bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of successful revascularization of coronary chronic total occlusions on long‐term clinical outcomes in patients with non‐ST‐segment elevation myocardial infarction
Authors: Teng Hsin‐I , Sung Shih‐Hsien , Huang Shao‐Sung , Pan Ju‐Pin , Lin Shing‐Jong , Chan Wan‐Leong , Lee Wen‐Lieng , Lu Tse‐Min , Wu Cheng‐Hsueh 
Published: March 2018

ObjectivesThe purpose of this study was to assess the long‐term clinical impact of revascularization of coronary concomitant coronary chronic total occlusion (CTO) in patients with Non‐ST‐segment elevation myocardial infarction (NSTEMI).BackgroundCTO is associated with poorer prognosis in patients with NSTEMI. The evidence of revascularization of CTO in patients with NSTEMI is still conflicting.MethodsConsecutive patients with NSTEMI and CTO who underwent percutaneous coronary intervention (PCI) within 72 h of admission from 2006 to 2015 were retrospectively recruited and analyzed. A total of 967 patients underwent PCI for NSTEMI. Among them, 106 (11%) patients had concomitant CTO and were recruited for analysis. CTO lesions were revascularized successfully in 67 (63.2%) patients (successful CTO PCI group), while the CTO in the remaining 39 patients were either not attempted or failed (No/failed CTO PCI group).ResultsThe 30‐day cardiac death and major adverse cardiac events (MACE) were significantly lower in the successful CTO PCI group (both cardiac death and MACE were 3% vs 30%, P < 0.001, respectively). A landmark analysis set at 30th day for 30‐day survivals was performed. After a mean of 2.5‐year follow‐up, the long‐term cardiac death was still significantly lower (16.9% vs 42.3%, P < 0.001), whereas the MACE showed a trend toward lower incidence (26.2% vs 40.7%, P = 0.051) in the successful CTO PCI group. In multivariate Cox regression analysis, successful revascularization of CTO is an independent protective predictor for long‐term cardiac death (HR 0.310, 95% CI, 0.109‐0.881, P = 0.028) in all population and in propensity‐score matched cohort (P = 0.007).ConclusionsSuccessful revascularization of CTO was associated with reduced risk of long‐term cardiac death in patients with NSTEMI and concomitant CTO.
We Are “Both in Charge, the Academics and Self‐Advocates”: Empowerment in Community‐Based Participatory Research
Authors: Stack Erin E. , McDonald Katherine 
Published: March 2018

AbstractBackground: Community‐based participatory research (CBPR) brings academics and community members into research partnerships. Although power is central to CBPR, little is known about community partners' experience with empowerment in CBPR with people with developmental disabilities. We interviewed 15 community partners with and without developmental disabilities about empowerment in CBPR. Community partners identified empowered mindsets and behaviors and CBPR factors that facilitated or hindered their empowerment. Our findings indicate CBPR provides opportunities for people with developmental disabilities to gain and develop important qualities, such as empowerment. However, CBPR partnerships need to be carefully constructed and monitored to fully realize positive outcomes.
Reproducibility of European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients treated with sorafenib
Authors: Jeon Mi Young , Lee Hye Won , Kim Beom Kyung , Park Jun Yong , Kim Do Young , Ahn Sang Hoon , Han Kwang‐Hyub , Baek Song‐Ee , Kim Hye Soo , Kim Seung Up , Park Mi Suk 
Published: March 2018

AbstractBackground & AimsThe European Association for the Study of the Liver criteria and the modified Response Evaluation Criteria in Solid Tumors are used for assessing the treatment outcomes of hepatocellular carcinoma. We investigated the inter‐ and intra‐observer reproducibility of the European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients with advanced hepatocellular carcinoma treated with sorafenib.MethodsA total of 99 patients with treatment‐naive advanced hepatocellular carcinoma receiving sorafenib were included. The κ‐values for the inter‐ and intra‐observer agreement of the treatment response were calculated.ResultsInter‐observer agreement for baseline tumour number was excellent, as reflected by the high κ‐value. The κ‐statistics showed “excellent” concordance between the 2 sets of measurements by observer A regarding the overall responses using the European Association for the Study of the Liver criteria (κ = .948, agreement rate = 84.8%) and modified Response Evaluation Criteria in Solid Tumors (κ = .944, agreement rate = 83.8%; all P < .001). In addition, high κ‐values indicated concordance between the first sets of measurements by observers A and B (κ = .991 by the European Association for the Study of the Liver criteria and .988 by modified Response Evaluation Criteria in Solid Tumors, all P < .001). When agreements in radiological overall responses between the 2 sets of measurements by observer B and between the second sets of measurements by observers A and B were calculated, similar results regarding high κ‐values (>.8) were obtained.ConclusionsThe reproducibility of the European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in assessing treatment outcomes was high in patients with advanced hepatocellular carcinoma treated with sorafenib.
Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy
Authors: Bae Joohwan , Sinn Dong Hyun , Kang Wonseok , Gwak Geum‐Youn , Choi Moon Seok , Paik Yong‐Han , Lee Joon Hyeok , Koh Kwang Cheol , Paik Seung Woon 
Published: March 2018

AbstractBackground & AimsThe Baveno VI and the expanded Baveno VI criteria were proposed to help identify patients who could safely avoid screening endoscopies for clinically significant varices among patients with compensated advanced chronic liver disease. However, these criteria require cross‐validation, especially in Asian populations where the aetiologies of liver disease are different.MethodsA total of 1035 patients, including 282 patients with compensated advanced chronic liver disease of different aetiology, were analysed. The compensated advanced chronic liver disease was defined by liver stiffness measurement ≥10 kPa, Child‐Pugh class A and absence of prior liver decompensation. High‐risk varix was defined as a grade ≥2 oesophageal varix, any varix with a red colour sign or gastric varices.ResultsHigh‐risk varixs were present in 19.5% (55/282 patients) with compensated advanced chronic liver disease. Among compensated advanced chronic liver disease patients, the expanded criteria could spare more endoscopies (51.7%) than the original criteria (27.6%). However, the expanded criteria missed a greater number of high‐risk varixs (6.8%) than the original criteria (3.8%). When stratified according to liver disease aetiology, the negative predictive values for the original Baveno VI criteria were 0.92, 1.00, 1.00 and 1.00, and the negative predictive values for the expanded criteria were 0.92, 0.96, 0.92 and 0.93 for hepatitis B, hepatitis C, alcohol and non‐alcoholic fatty liver disease, respectively. High‐risk varixs were rarely detected in patients without compensated advanced chronic liver disease (1.1%, 8/753 patients).ConclusionsIn this Asian cohort study, the Baveno VI criteria were able to identify who could safely avoid screening endoscopy. The expanded Baveno VI criteria could spare more endoscopies but also could increase the odds of missing a high‐risk varix.
Ethiopian women's perspectives on antenatal care and iron‐folic acid supplementation: Insights for translating global antenatal calcium guidelines into practice
Authors: Birhanu Zewdie , Chapleau Gina M. , Ortolano Stephanie E. , Mamo Girma , Martin Stephanie L. , Dickin Katherine L. 
Published: March 2018

AbstractAfter decades of global response to iron‐deficiency anemia, lessons learned from antenatal iron‐folic acid (IFA) supplementation can inform new micronutrient supplementation efforts. The World Health Organization recommends calcium supplementation for the prevention of preeclampsia; however, little is documented on how to design programs to integrate calcium into the standard of care. Twenty interviews with pregnant women and 22 interviews with health providers and volunteers in two districts in Ethiopia were conducted to examine how barriers and facilitators to antenatal care, IFA supplementation, and initial reactions to calcium supplements and regimen might influence adherence and inform future programs. Women viewed supplementation positively but cited lack of information on benefits and risks, forgetfulness, and inconsistent IFA supply as challenges. Though knowledge and awareness of anemia and IFA supplements were widespread, preeclampsia was mostly unknown. Some symptoms of preeclampsia were viewed as normal in pregnancy, making it difficult to convey risk to motivate supplement use. Some women viewed co‐consumption of IFA and calcium as potentially harmful and were confused regarding the simultaneous risks of anemia and hypertension, understood as “low” and “high” blood levels in pregnancy. However, most said they would take both IFA and calcium supplements if provided with supplements and counseling on purpose and benefits. Strategies such as social support from families, stronger community‐based counseling, and increased health care provider and community awareness of preeclampsia are critical for women to understand the benefits of supplementation and resolve confusion caused by current descriptors used for anemia and hypertension.
Measuring movement towards improved emergency obstetric care in rural Kenya with implementation of the PRONTO simulation and team training program
Authors: Dettinger Julia C. , Kamau Stephen , Calkins Kimberly , Cohen Susanna R. , Cranmer John , Kibore Minnie , Gachuno Onesmus , Walker Dilys 
Published: March 2018

AbstractAs the proportion of facility‐based births increases, so does the need to ensure that mothers and their newborns receive quality care. Developing facility‐oriented obstetric and neonatal training programs grounded in principles of teamwork utilizing simulation‐based training for emergency response is an important strategy for improving the quality care. This study uses 3 dimensions of the Kirkpatrick Model to measure the impact of PRONTO International (PRONTO) simulation‐based training as part of the Linda Afya ya Mama na Mtoto (LAMMP, Protect the Health of mother and child) in Kenya. Changes in knowledge of obstetric and neonatal emergency response, self‐efficacy, and teamwork were analyzed using longitudinal, fixed‐effects, linear regression models. Participants from 26 facilities participated in the training between 2013 and 2014. The results demonstrate improvements in knowledge, self‐efficacy, and teamwork self‐assessment. When comparing pre‐Module I scores with post‐training scores, improvements range from 9 to 24 percentage points (p values < .0001 to .026). Compared to baseline, post‐Module I and post‐Module II (3 months later) scores in these domains were similar. The intervention not only improved participant teamwork skills, obstetric and neonatal knowledge, and self‐efficacy but also fostered sustained changes at 3 months. The proportion of facilities achieving self‐defined strategic goals was high: 95.8% of the 192 strategic goals. Participants rated the PRONTO intervention as extremely useful, with an overall score of 1.4 out of 5 (1, extremely useful; 5, not at all useful). Evaluation of how these improvements affect maternal and perinatal clinical outcomes is forthcoming.
Integrating nutrition into health systems at community level: Impact evaluation of the community‐based maternal and neonatal health and nutrition projects in Ethiopia, Kenya, and Senegal
Authors: Kung'u Jacqueline K. , Pendame Richard , Ndiaye Mame Bineta , Gerbaba Mulusew , Ochola Sophie , Faye Adama , Basnet Sulochana , Frongillo Edward A. , Wuehler Sara , De‐Regil Luz Maria 
Published: March 2018

AbstractMaternal undernutrition and mortality remain high in several African countries. Key nutrition and health interventions improve maternal and birth outcomes. Evidence is scarce on how to strengthen health systems to ensure pregnant women and newborns are reached with these interventions. We conducted three quasi‐experimental nonrandomized Community Based Maternal and Neonatal Health and Nutrition projects in regions of Ethiopia, Senegal, and Kenya to demonstrate how proven nutrition interventions could be integrated into health programs to improve knowledge and practices during pregnancy, birth, and postpartum. We evaluated impact on knowledge and practices related to maternal and neonatal care using logistic regression and repeated‐measures models with districts as a fixed variable and adjusted for covariates. Combined country analyses show significant positive effects of the intervention on women receiving first antenatal care visit (ANC) during first trimester (OR = 1.44; p < .001), those consuming any iron and folic acid supplement during their latest pregnancy (OR = 1.60; p = .005), those whose <6 months infants were exclusively breastfed (OR = 2.01; p=.003), those whose delivery was facility based (OR = 1.48; p=.031), and those whose postnatal care was facility based (OR = 2.15; p<.001). There was no significant differences between intervention and control groups regarding one or more and four or more ANC visits, women consuming iron and folic acid for ≥90 days, and early initiation of breastfeeding. We conclude that integrating proven nutrition interventions into health programs at community level improved components of access to and use of ANC, delivery services, and postnatal care by women in three African countries.
Comparison of cause of death between Australian and New Zealand Dialysis and Transplant Registry and the Australian National Death Index
Authors: Sypek Matthew P , Dansie Kathryn B , Clayton Phil , Webster Angela C , Mcdonald Stephen 
Published: March 2018

ABSTRACTAimThe aim of the present study was to understand the differences in how cause of death for patients receiving renal replacement therapy in Australia is recorded in The Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) compared to the National Death Index (NDI).MethodsData linkage was performed between ANZDATA and NDI for all deaths in the period 1980–2013. Cause of death was classified according to ICD‐10 chapter. Overall and chapter specific agreement were assessed using the Kappa statistic. Descriptive analysis was used to explore differences where there was disagreement on primary cause of death.ResultsThe analysis cohort included 28 675 patients. Ninety five percent of ANZDATA reported deaths fell within +/− 3 days of the date recorded by NDI. Circulatory death was the most common cause of death in both databases (ANZDATA 48%, NDI 32%). Overall agreement at ICD chapter level of primary cause was poor (36%, kappa 0.22). Agreement was best for malignancy (kappa 0.71). When there was disagreement on primary cause of death these were most commonly coded as genitourinary (35%) and endocrine (25.0%) in NDI, and circulatory (39%) and withdrawal (24%) in ANZDATA. Sixty‐nine percent of patients had a renal related cause documented as either primary or a contributing cause of death in the NDI.ConclusionThere is poor agreement in primary cause of death between ANZDATA and NDI which is in part explained by the absence of diabetes and renal failure as causes of death in ANZDATA and the absence of ‘withdrawal’ in NDI. These differences should be appreciated when interpreting epidemiological data on cause of death in the Australian end stage kidney disease population.
Group 2 innate lymphocytes at the interface between innate and adaptive immunity
Authors: Schuijs Martijn J. , Halim Timotheus Y.F. 
Published: March 2018

AbstractGroup 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell‐to‐cell interactions. As tissue‐resident sentinels, ILC2 help orchestrate localized type 2 immune responses. These ILC2‐driven type 2 responses are now recognized in diverse immune processes, different anatomical locations, and homeostatic or pathological settings. ILC2‐derived cytokines and cell surface signaling molecules function as key regulators of innate and adaptive immunity. Conversely, ILC2 are governed by their environment. As such, ILC2 form an important nexus of the immune system and may present an attractive target for immune modulation in disease.
Riparian reforestation with a single exotic species restores soil aggregation and porosity but not humic substances
Authors: Santos H. V. , Scotti M. R. 
Published: March 2018

AbstractA degraded riparian area in the Uberaba River basin (Brazil) was restored by local landowners using a monoculture of the exotic species Syzygium cumini (L.) Skeels over 15 years. To assess this riparian restoration, we compared this experimental site (ES) with a disturbed site (DS) and a preserved site (PS) with regard to soil organic matter, humic and fulvic acids (HA and FA), glomalin, soil aggregation and porosity. The results did not show significant differences between ES and PS with regard to soil aggregation and porosity. The cation exchange capacity and the HA and FA contents of ES were significantly different from those in PS and DS. Whereas the HA content of ES was less than that in PS, FA was significantly increased. The order of aromatic composition of humic substances by site was PS > ES > DS and contrasted with the aliphatic composition, which was DS > ES > PS. A principal component analysis based on all variables demonstrated that ES was closer to PS than to DS but that there was no overlap among sites, as PS was driven by humic aromatic substances and the experimental site by fulvic and aliphatic compounds. We concluded that there was a functional recovery of ecosystem services related to soil aggregation and porosity, but the qualitative differences in organic matter formation between the restored and preserved sites were not consistent with ES being fully restored.
Natural variation in the promoter of rice calcineurin B‐like protein10 (OsCBL10) affects flooding tolerance during seed germination among rice subspecies
Authors: Ye Neng‐Hui , Wang Feng‐Zhu , Shi Lu , Chen Mo‐Xian , Cao Yun‐Ying , Zhu Fu‐Yuan , Wu Yi‐Zhen , Xie Li‐Juan , Liu Tie‐Yuan , Su Ze‐Zhuo , Xiao Shi , Zhang Hao , Yang Jianchang , Gu Hai‐Yong , Hou Xuan‐Xuan , Hu Qi‐Juan , Yi Hui‐Juan , Zhu Chang‐Xiang , Zhang Jianhua , Liu Ying‐Gao 
Published: March 2018

SummaryRice (Oryza sativa L.) has two ecotypes, upland and lowland rice, that have been observed to show different tolerance levels under flooding stress. In this study, two rice cultivars, upland (Up221, flooding‐intolerant) and lowland (Low88, flooding‐tolerant), were initially used to study their molecular mechanisms in response to flooding germination. We observed that variations in the OsCBL10 promoter sequences in these two cultivars might contribute to this divergence in flooding tolerance. Further analysis using another eight rice cultivars revealed that the OsCBL10 promoter could be classified as either a flooding‐tolerant type (T‐type) or a flooding‐intolerant type (I‐type). The OsCBL10 T‐type promoter only existed in japonica lowland cultivars, whereas the OsCBL10 I‐type promoter existed in japonica upland, indica upland and indica lowland cultivars. Flooding‐tolerant rice cultivars containing the OsCBL10 T‐type promoter have shown lower Ca2+ flow and higher α‐amylase activities in comparison to those in flooding‐intolerant cultivars. Furthermore, the OsCBL10 overexpression lines were sensitive to both flooding and hypoxic treatments during rice germination with enhanced Ca2+ flow in comparison to wild‐type. Subsequent findings also indicate that OsCBL10 may affect OsCIPK15 protein abundance and its downstream pathways. In summary, our results suggest that the adaptation to flooding stress during rice germination is associated with two different OsCBL10 promoters, which in turn affect OsCBL10 expression in different cultivars and negatively affect OsCIPK15 protein accumulation and its downstream cascade.
ABO and D typing and alloantibody screening in marrow samples: relevance to intraosseous blood transfusion
Authors: Bäckman Sari , Ångerman‐Haasmaa Susanne , Jousi Milla , Siitonen Sanna , Salmela Katja 
Published: March 2018

BACKGROUNDBlood transfusion through the intraosseous route is gaining popularity in emergency medicine. Pretransfusion peripheral blood (PB) samples are usually not available in these patients, leading to discrepancies in blood group typing and a possible delay in transferring to group‐specific blood products. The aim of this study was to assess the feasibility of ABO and D typing and red blood cell alloantibody screening in marrow (BM) samples.STUDY DESIGN AND METHODSDirect and reverse ABO typing, D typing, and a two‐cell alloantibody screen were performed in EDTA‐anticoagulated BM samples with standard manual column agglutination techniques. EDTA‐anticoagulated PB samples were used as controls.RESULTSThe mean age of the study subjects (n = 71) was 47 years (range, 1‐82 years). All ABO groups and both D+ and D– types were represented. In all subjects, concordant results were observed for all analyses in BM and PB samples. In 15 (21%) of the samples, a discrepancy of one reaction strength step (1+) was observed in at least one of the analyses (Cohen's weighted κ = 0.993); this did not affect interpretation of the results.CONCLUSIONBlood group typing and alloantibody screening are feasible in BM samples, providing proof‐of‐concept that intraosseous samples for blood group serologic analyses can be collected from emergency patients before intraosseous blood transfusion. This will enable a timely transfer to group‐specific blood products and enable conservation of the valuable universal‐donor blood products.
Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR
34
/L98H/S297T/F495I Mutation
Authors: Chen Yong , Li Zongwei , Han Xuelin , Tian Shuguang , Zhao Jingya , Chen Fangyan , Su Xueting , Zhao Jingjun , Zou Ziying , Gong Yanwen , Qu Fen , Qiu Guangbin , Wang Siyao , Jia Xiaodong , Lu Zhongyi , Hu Mandong , Huang Liuyu , Verweij Paul E. , Han Li 
Published: March 2018

ABSTRACT

The use of azole fungicides in agriculture is believed to be one of the main reasons for the emergence of azole resistance in
Aspergillus fumigatus
. Though widely used in agriculture, imidazole fungicides have not been linked to resistance in
A. fumigatus
. This study showed that elevated MIC values of imidazole drugs were observed against
A. fumigatus
isolates with TR
34
/L98H/S297T/F495I mutation, but not among isolates with TR
34
/L98H mutation. Short-tandem-repeat (STR) typing analysis of 580
A. fumigatus
isolates from 20 countries suggested that the majority of TR
34
/L98H/S297T/F495I strains from China were genetically different from the predominant major clade comprising most of the azole-resistant strains and the strains with the same mutation from the Netherlands and Denmark. Alignments of sterol 14α-demethylase sequences suggested that F495I in
A. fumigatus
was orthologous to F506I in
Penicillium digitatum
and F489L in
Pyrenophora teres
, which have been reported to be associated with imidazole resistance.
In vitro
antifungal susceptibility testing of different recombinants with
cyp51A
mutations further confirmed the association of the F495I mutation with imidazole resistance. In conclusion, this study suggested that environmental use of imidazole fungicides might confer selection pressure for the emergence of azole resistance in
A. fumigatus
.