bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and demonstrates anti-inflammatory mechanism of action
Authors: Hamilton Amanda M. , Cheung Wing-Yee , Gómez-Aristizábal Alejandro , Nakamura Sayaka , Chaboureau Amélie , Bhatt Shashank , Sharma Anirudh , Kapoor Mohit , Foster Paula J. , Viswanathan Sowmya 
Published: March 2019

AbstractOsteoarthritis (OA) is characterized by cartilage degradation and chronic joint inflammation. Mesenchymal stem cells (MSCs) have shown promising results in OA, but their mechanism of action is not fully understood. We hypothesize that MSCs polarize macrophages, which are strongly associated with joint inflammation to more homeostatic sub-types. We tracked ferumoxytol (Feraheme™, iron oxide nanoparticle)-labeled murine MSCs (Fe-MSCs) in murine OA joints, and quantified changes to homeostatic macrophages.10-week-old C57BL/6 male mice (n=5/group) were induced to undergo osteoarthritis by destabilization of medical meniscus (DMM) or sham surgery. 3 weeks post-surgery, mice were injected intra-articularly with either fluorescent dye-(DiR) labeled or DiR+ferumoxytol-labeled (DiR+Fe) bone marrow mesenchymal stem cells (MSC, 50×103MSCs/mouse) or saline (control), to yield 4 groups (n=5 per group for each timepoint [1, 2 and 4weeks]): i) DMM+Saline; ii) DMM+DiR+Fe-MSC; iii) DMM+DiR MSC; iv) SHAM+DiR+Fe-MSC and saline in contralateral knee. 4 weeks after injection, mice were imaged by MRI, and scored for i) OARSI to determine cartilage damage and ii) immunohistochemical changes in CD206, F480 and Prussian Blue/Sca-1 to detect homeostatic macrophages, total macrophages and ferumoxytol-labeled MSCs respectively.Ferumoxytol-labeled MSCs persisted in DMM knee joints at greater levels than in SHAM-MSC knee joints. We observed no difference in OARSI scores between MSC and vehicle groups. Sca-1 and Prussian Blue co-staining confirmed the ferumoxytol label resides in MSCs, although some ferumoxytol label was detected in proximity to MSCs in macrophages, likely due to phagocytosis of apoptotic MSCs, increasing functionality of these macrophages through MSC efferocytosis. We showed decreased MRI synovitis scores in MSC-treated compared to control animals. For the first time we show that MSC-treated OA mice had increased macrophage infiltration (p<0.08) with an increased proportion of CD206+ (homeostatic) macrophages (p<0.01), supporting our hypothesis that MSCs modulate synovial inflammation.
Flawed organizational purpose? Changing the narrative in management education and practice
Authors: Marques Joan F. 
Published: March 2019

Purpose
The purpose of this paper is to challenge current and future organizational managers toward engaging in a process of reflecting on the purpose of their performance and the purpose of the organization they serve and also to challenge management educators and coaches to reflect on the emphasis of their training of those who will step into management positions.

Design/methodology/approach
This paper reviews the current criticism on organizational management education and practice, and brings global inequality in the scope to underscore the importance of correcting a flawed system based on a flawed perspective.

Findings
It is critical to change the narrative the authors use for management in organizations from, “organizations exist to maximize the value of their shareholders, and the managers in those organizations need to ensure that this happens” to, “organizations exist to support the communities in which they operate, and managers in those organizations need to ensure that this happens.”

Practical implications
Organizational managers will focus on a more socially acceptable set of priorities when adopting the narrative promoted in this paper. Business educators will focus on more transdisciplinary approaches to help their students think beyond self-centered and sheer profit-based boundaries, and plant seeds toward constructive and morally sound social change early on.

Social implications
Communities will fare much better when the organizations in their areas will focus more on well-being of those who reside in the community rather than a handful of often absent shareholders.

Originality/value
This paper questions the core of organizational existence and managerial performance therein. It reaches beyond technological, operational, and tactical levels of performance and questions the grand strategy of organizational existence and performance.
Alibaba strategist Ming Zeng: “Smart business” in the era of business ecosystems
Authors: Leavy Brian 
Published: March 2019

Purpose
Alibaba strategist Ming Zeng explains how the company operates its “smart business” in the era of business ecosystems

Design/methodology/approach
Alibaba today presents a vivid picture of the new business world emerging, one that operates using the data generated by the network of participants, as processed by machine learning, to automatically respond to customer behavior and preferences in real time.

Findings
At Alibaba link after link in the value chain is being modularized and reconfigured into technologically optimized networks and much of business decision-making is powered by algorithms.

Practical implications
Creativity becomes the crucial productive factor and thus the purpose of an organization is to enable, rather than manage creative people.

Originality/value
<abstract_text>In the emerging world of “smart business,” entrepreneurs and strategists must learn to assess the entire network as a whole when deciding how to position their business and create value. Then the strategy making process is one of generating, coordinating and modulating experimentation
How design thinking opens new frontiers for strategy development
Authors: Liedtka Jeanne , Kaplan Saul 
Published: March 2019

Purpose
This article explains how design thinking and practices can identify unexplored opportunities for strategic growth. Increasingly practitioners are learning about powerful ways they can work together, with design mindsets and practices improving the strategy development process in multiple ways.

Design/methodology/approach
By integrating design practices into strategy development, practitioners can produce both incremental improvement in the performance of today’s business model and open opportunities to completely transform it.

Findings
Using design thinking, to understand the job customers are trying to do and the problem they have doing it allows strategists to craft a new potential offering and shape a value proposition that creates greater value than existing alternatives.”

Practical implications
The first design practice worth integrating into strategy development is human-centered design (HCD), with its tools that explore multiple pathways for growth through the experience of customers, the perspectives of “uncommon” partners, and the untapped local intelligence of employees.

Originality/value
The capability set design thinking offers – the focus on customers’ job-to-be-done, the ability to prototype and experiment, to manage a portfolio of bets, and to foster engagement and alignment – can provide what successful growth, whether incremental or disruptive, demands.
Target‐oriented imaging using extended image volumes: a low‐rank factorization approach
Authors: Kumar Rajiv , Graff Marie , Vasconcelos Ivan , Herrmann Felix J. 
Published: March 2019

ABSTRACTImaging in geological challenging environments has led to new developments, including the idea of generating reflection responses by means of interferometric redatuming at a given target datum in the subsurface, when the target datum lies beneath a complex overburden. One way to perform this redatuming is via conventional model‐based wave‐equation techniques. But those techniques can be computationally expensive for large‐scale seismic problems since the number of wave‐equation solves is equal to two times the number of sources involved during seismic data acquisition. Also conventional shot‐profile techniques require lots of memory to save full subsurface extended image volumes. Therefore, we can only form subsurface image volumes in either horizontal or vertical directions. To exploit the information hidden in full subsurface extended image volumes, we now present a randomized singular value decomposition‐based approach built upon the matrix probing scheme, which takes advantage of the algebraic structure of the extended imaging system. This low‐rank representation enables us to overcome both the computational cost associated with the number of wave‐equation solutions and memory usage due to explicit storage of full subsurface extended image volumes employed by conventional migration methods. Experimental results on complex geological models demonstrate the efficacy of the proposed methodology and allow practical reflection‐based extended imaging for large‐scale five‐dimensional seismic data.
Wild bacterial probiotics fed to larvae of mass‐reared Queensland fruit fly [Bactrocera tryoni (Froggatt)] do not impact long‐term survival, mate selection, or locomotor activity
Authors: Shuttleworth Lucas A. , Khan Mohammed Abul Monjur , Collins Damian , Osborne Terry , Reynolds Olivia L. 
Published: March 2019

AbstractQueensland fruit fly [Bactrocera tryoni (Froggatt), Diptera, Tephritidae] is the most devastating insect pest impacting Australian horticulture. The Sterile Insect Technique (SIT) is an important component of tephritid pest management programs. However, mass‐rearing and irradiation (to render insects sterile) may reduce the fitness and performance of the insect, including the ability of sterile males to successfully compete for wild females. Manipulation of the gut microbiome, including the supplementation with bacterial probiotics shows promise for enhancing the quality of mass‐reared sterile flies, however there are fewer published studies targeting the larval stage. In this study, we supplemented the larval stage of mass‐reared B. tryoni with bacterial probiotics. We tested several individual bacteria that had been previously isolated and characterized from the gut of wild B. tryoni larvae including Asaia sp., Enterobacter sp., Lactobacillus sp., Leuconostoc sp. We also tested a consortium of all four of these bacterial isolates. The fitness parameters tested included adult survival in field cages, laboratory mate selection of bacteria supplemented males by bacteria nonsupplemented females, and laboratory locomotor activity of adult flies. None of the bacterial probiotic treatments in the current study was significantly different to the control for field survival, mate selection or locomotor activity of adult B. tryoni, which agree with some of the other studies regarding bacterial probiotics fed to the larval stage of tephritids. Future work is needed to determine if feeding the same, and/or other probiotics to adults, as opposed to larvae can positively impact survival, mating performance, mating competitiveness and locomotor activity of B. tryoni. The bacterial group(s) and function of bacterial species that increase fitness and competitiveness is also of interest to tephritid mass‐rearing programs.
Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders
Authors: Gohar S. M. , Dieset I. , Steen N. E. , Mørch R. H. , Vedal T. S. J. , Reponen E. J. , Steen V. M. , Andreassen O. A. , Melle I. 
Published: March 2019

ObjectiveAssociations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in schizophrenia, together with the influence of other clinical and biological indices.MethodWe recruited a sample of 270 participants with schizophrenia spectrum diagnoses. Blood samples were analysed for leptin, while symptom severity was assessed by Positive and Negative Syndrome Scale (PANSS) and Inventory of Depressive Symptomatology (IDS‐C). Patients' history of suicidal behaviour was categorized into three subgroups based on IDS‐C suicide subscale: No suicidal behaviour, mild/moderate suicidal behaviour and severe suicidal behaviour with/without attempts.ResultsMild/moderate suicidal behaviour was present in 17.4% and severe suicidal behaviour in 34.8%. Both groups were significantly associated with female gender (OR = 6.0, P = 0.004; OR = 5.9, P = 0.001), lower leptin levels (OR = 0.4, P = 0.008; OR = 0.5, P = 0.008) and more severe depression (OR = 1.2, P < 0.001; OR = 1.1, P < 0.001) respectively. Smoking (OR = 2.6, P = 0.004), younger age of onset (OR = 0.9, P = 0.003) and less use of leptin‐increasing medications (OR = 0.5, P = 0.031) were associated with severe/attempts group, while higher C‐reactive protein CRP (OR = 1.3, P = 0.008) was associated with mild/moderate group.ConclusionLower leptin levels were associated with higher severity of suicidal behaviour in schizophrenia.
Portrayal of bariatric surgery in the New Zealand print news media
Authors: Rahiri Jamie‐Lee , Barazanchi Ahmed , Gillon Ashlea , MacCormick Andrew , Harwood Matire , Hill Andrew 
Published: March 2019

BackgroundBariatric surgery has become topical in the media worldwide, influencing wider societal attitudes towards obesity and obesity management. This study aims to explore the media portrayal of bariatric surgery in all print news articles published in New Zealand (NZ) over a decade.MethodsAn electronic search of two databases (Proquest Australia/NZ Newsstream and Newztext) and two NZ news media websites (Stuff and the NZ Herald) was performed to retrieve print news articles reporting stories, opinion pieces or editorials regarding bariatric surgery published between January 2007 to June 2017. Qualitative thematic analysis was performed on all included articles.ResultsFrom January 2007 to December 2017, 252 articles related to bariatric surgery were published. Seven major themes emerged centred around barriers to accessing bariatric surgery, deficit attitudes towards obesity and social justice. These views were driven by articles that debated the limited number of publicly funded bariatric procedures offered in NZ. In addition, healthcare professionals used the media as a platform to challenge discriminatory attitudes towards obesity and bariatric surgery.ConclusionThe NZ media is a powerful tool that still bolsters binary perspectives of obesity and bariatric surgery which may work against addressing the obesity epidemic.
Clinical decision support improves quality of care in patients with ulcerative colitis
Authors: Jackson Belinda , Begun Jake , Gray Kathleen , Churilov Leonid , Liew Danny , Knowles Simon , De Cruz Peter 
Published: March 2019

SummaryBackgroundDecision support tools may facilitate shared decision‐making and improve quality of care.AimTo assess the effectiveness of a decision support tool on improving quality of care in ulcerative colitis.MethodsA prospective quality of care intervention was conducted at two Australian hospitals comparing out‐patient–based ulcerative colitis care with, and without, a tablet‐based decision support tool. This included questions on disease activity management; psychological well‐being; and preventive care, with 13 process indicators relevant to each domain. Participants included adult out‐patients with mild‐to‐moderate ulcerative colitis and their clinicians who were divided into two cohorts. The first cohort were followed up immediately after their clinical review to check whether their clinician had discussed the 13 process indicators during the consultation. The second cohort of patients used the decision support tool immediately prior to their consultation which then generated a suggested management plan for the patient and clinician to discuss during the consultation. Management between the 2 cohorts was compared to assess the effectiveness of the decision support tool in improving the primary outcome, defined as the proportion of quality process indicators used for ulcerative colitis care, with and without the decision support tool.ResultsThirteen physicians and 100 patients participated. Fifty patients were managed without the decision support tool using standard care (median age 40; 44% male), and 50 patients used the decision support tool (median age 40; 46% male) over a 20‐week period. Increase in the median use of process indicators overall was observed following use of the decision support tool (27% vs 100%; P < 0.001). Improvements were seen in psychological well‐being management (30% vs 100%; P < 0.001), preventive care (16% vs 100%; P < 0.001) and process indicators related to disease activity management (50% vs 100%; P < 0.001). The decision support tool was found to be usable and acceptable. Shared decision‐making was greater in the post‐intervention group (mean decision conflict score of 18.0 vs 33.5; P = 0.002).ConclusionsThe decision support tool substantially improved the quality of the delivery of care. Decision support tools have the potential to minimise errors of omission via a standardised approach to care.
Prevotella copri, a potential indicator for high feed efficiency in western steers
Authors: Brooke Charles G. , Najafi Negeen , Dykier Katherine C. , Hess Matthias 
Published: March 2019

AbstractThere has been a great interest to identify a microbial marker that can be used to predict feed efficiency of beef cattle. Such a marker, specifically one that would allow an early identification of animals with high feed efficiency for future breeding efforts, would facilitate increasing the profitability of cattle operations and simultaneously render them more sustainable by reducing their methane footprint. The work presented here suggests that Prevotella copri might be an ideal microbial marker for identifying beef cattle with high feed efficiency early in their life span and in the production cycle. Developing more refined quantification techniques that allow correlation of P. copri to feed efficiency of beef cattle that can be applied by lay people in the field holds great promise to improve the economy of cattle operations while simultaneously reducing their environmental impact by mitigating methane production from enteric fermentation.
Exploring primary school teachers’ technological pedagogical content knowledge (TPACK) in online collaborative discourse: An epistemic network analysis
Authors: Zhang Si , Liu Qingtang , Cai Zhiqiang 
Published: March 2019

AbstractThe contextual influences on technological pedagogical content knowledge (TPACK) enactment and the method of TPACK assessment remain to be important research topics. Discourse data of 81 teachers in an online professional learning community were collected and analyzed based on the framework of TPACK. Frequency distribution and time series characteristics of teachers’ knowledge domains were analyzed. In addition, epistemic network analysis was used to compare the epistemic network characteristics of teachers in the higher‐score and the lower‐score groups, different age groups, and post and reply groups. Results showed that teachers’ knowledge domains enacted in the context of online discourse were mainly pedagogical content knowledge and general pedagogical knowledge. The teachers in the higher‐score group had a rich, organized and flexible knowledge structure of TPACK. Younger teachers had more connections between pedagogical knowledge and pedagogical content knowledge, while senior teachers had more connections between technological knowledge and pedagogical knowledge. The teachers in the reply group had more connections among the different categories of knowledge as compared to the post group. Finally, implications, limitations and future research were discussed.
Subacute fatigue in primary care – two sides of the story
Authors: Hulme Katrin , Little Paul , Burrows Abigail , Julia Anna , Moss‐Morris Rona 
Published: March 2019

ObjectivesFatigue is a common symptom in primary care. Chronic fatigue research highlights the value of preventing chronicity, but little research has investigated the early, subacute stage of the fatigue trajectory (<3 months). We aimed to examine patient and general practitioner (GP) perspectives of subacute fatigue in primary care: (1) to gain a better understanding of fatigue during this stage and (2) to explore how management could be improved.DesignA qualitative study design was used. In‐depth, semi‐structured telephone interviews were conducted with 14 patients and 14 GPs (non‐dyadic), recruited from 19 primary care practices.MethodsInterview transcripts were thematically analysed. Initially, patient and GP accounts were analysed separately, before themes were merged to identify shared and independent perspectives.ResultsThree main themes were identified. Within these, subthemes from patients’, GPs’, or shared patient/GP perspectives emerged. The main themes encompassed the following: (1) Change from normal – the impact of fatigue; (2) The challenges of managing fatigue; and (3) The consultation GPs’ knowledge was often not reflected in patients’ accounts, even for those reporting positive experiences, suggesting knowledge was not effectively translated.ConclusionsSome findings, such as impact, mirror those described in chronic fatigue. New insights into early‐stage fatigue management also arose, including mismatches in patient and GP perceptions on negative tests and not re‐presenting. These highlight the need for better communication and shared understanding. GPs should pre‐emptively present a biopsychosocial model of fatigue and keep communication channels open, particularly in the light of negative physiological tests.
Statement of contribution

What is already known on this subject?

Patients with chronic fatigue retrospectively report lack of understanding from GPs in early stage of illness.

Little research has investigated the early stages of the fatigue trajectory.

What does this study add?

Consequences of an episode of subacute fatigue are similar to those reported for CFS.

There is discordance between GPs’ positive view of negative tests and patients’ need for explanation of symptoms.

The length of appointments is a significant barrier for creating shared understanding.
NOMINAL GDP TARGETING AND CENTRAL BANK CONSERVATIVENESS
Authors: Dai Yuwen , Xu Bin 
Published: March 2019

ABSTRACTIn the literature on monetary economics, there is the ‘inflationary bias’ result which predicts that the rate of inflation will be biased towards a higher level under discretionary monetary policy than under a rule‐based policy regime. It is established that a credible nominal target can eliminate this ‘inflationary bias’. In this paper, we examine the case of nominal GDP targeting, which is a rule‐based monetary regime. Depending on the degree of conservativeness by the central bank, we show in a stylized model the choice of different combination of inflation and real GDP targets can still result in an ‘inflationary bias’, and there also exists the possibility of a ‘dis‐inflationary bias’.