bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Cytomegalovirus Infection in Women With Preexisting Immunity: Sources of Infection and Mechanisms of Infection in the Presence of Antiviral Immunity
Authors: Britt William J 
Published: September 2019

AbstractHuman cytomegalovirus (HCMV) infection remains an important cause of neurodevelopmental sequelae in infants infected in utero. Unique to the natural history of perinatal HCMV infections is the occurrence of congenital HCMV infections (cCMV) in women with existing immunity to HCMV, infections that have been designated as nonprimary maternal infection. In maternal populations with a high HCMV seroprevalence, cCMV that follows nonprimary maternal infections accounts for 75%–90% of all cases of cCMV infections as well as a large proportion of infected infants with neurodevelopmental sequelae. Although considerable effort has been directed toward understanding immune correlates that can modify maternal infections and intrauterine transmission, the source of virus leading to nonprimary maternal infections and intrauterine transmission is not well defined. Previous paradigms that included reactivation of latent virus as the source of infection in immune women have been challenged by studies demonstrating acquisition and transmission of antigenically distinct viruses, a finding suggesting that reinfection through exposure to an exogenous virus is responsible for some cases of nonprimary maternal infection. Additional understanding of the source(s) of virus that leads to nonprimary maternal infection will be of considerable value in the development and testing of interventions such as vaccines designed to limit the incidence of cCMV in populations with high HCMV seroprevalence.
Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract With Hematopoietic Stem Cell Transplantation
Authors: Boonyaratanakornkit Jim , Vivek Meghana , Xie Hu , Pergam Steven A , Cheng Guang-Shing , Mielcarek Marco , Hill Joshua A , Jerome Keith R , Limaye Ajit P , Leisenring Wendy , Boeckh Michael J , Waghmare Alpana 
Published: September 2019

AbstractBackgroundHematopoietic cell transplant (HCT) recipients are frequently infected with respiratory viruses (RVs) in the upper respiratory tract (URT), but the concordance between URT and lower respiratory tract (LRT) RV detection is not well characterized.MethodsHematopoietic cell transplant candidates and recipients with respiratory symptoms and LRT and URT RV testing via multiplex PCR from 2009 to 2016 were included. Logistic regression models were used to analyze risk factors for LRT RV detection.ResultsTwo-hundred thirty-five HCT candidates or recipients had URT and LRT RV testing within 3 days. Among 115 subjects (49%) positive for a RV, 37% (42 of 115) had discordant sample pairs. Forty percent (17 of 42) of discordant pairs were positive in the LRT but negative in the URT. Discordance was common for adenovirus (100%), metapneumovirus (44%), rhinovirus (34%), and parainfluenza virus type 3 (28%); respiratory syncytial virus was highly concordant (92%). Likelihood of LRT detection was increased with URT detection (oods ratio [OR] = 73.7; 95% confidence interval [CI], 26.7–204) and in cytomegalovirus-positive recipients (OR = 3.70; 95% CI, 1.30–10.0).ConclusionsHigh rates of discordance were observed for certain RVs. Bronchoalveolar lavage sampling may provide useful diagnostic information to guide management in symptomatic HCT candidates and recipients.
Promoting Compliance with Human Rights: The Performance of the United Nations’ Universal Periodic Review and Treaty Bodies
Authors: Carraro Valentina 
Published: September 2019

AbstractWhat mechanisms facilitate state compliance with human rights? This article proposes and applies a model to assess the extent to which two United Nations human rights mechanisms—the Universal Periodic Review (UPR) and the state reporting procedure of the treaty bodies—are perceived as capable of stimulating compliance with human rights, and why. It does so by identifying a set of goals potentially achieved by these organizations—generating pressure, stimulating learning, providing an accurate overview of states’ performance, and delivering practically feasible recommendations—and testing the extent to which reaching these goals is seen to facilitate compliance with human rights. It concludes that the treaty bodies’ perceived strength lies in providing states with learning opportunities and an accurate overview of their internal situations. In contrast, the UPR is deemed particularly strong in generating peer and public pressure on states. From a theoretical point of view, this article shows that, under certain conditions, the three main theoretical schools on compliance—enforcement, management, and constructivist—offer credible explanations for states’ performance in implementing human rights recommendations, with the enforcement school faring relatively better than the other two. Data were collected by means of forty semi-structured interviews and an online survey.
Microlevel Security after Armed Conflict: A New Framework for Analyzing Risks and Benefits of Peacebuilding Processes
Authors: Guthrey Holly L 
Published: September 2019

Abstract
The maintenance and/or achievement of security is of paramount importance within settings recovering from armed conflict; however existing studies in the field of peacebuilding do not sufficiently explore how various processes undertaken within peacebuilding programming result in different types of security outcomes at the individual and community level. In this article, I develop a novel conceptual framework for analyzing “microlevel” security risks and benefits of peacebuilding processes, through an adapted version of Johan Galtung's work on direct and structural violence. For the purposes of this article, the framework is applied in the context of “local” transitional justice (TJ) processes used in the aftermath of armed conflict, for which advocacy and implementation has increased in the recent past. Relying on a social psychological definition of security, I disaggregate components of direct and structural violence and use illustrative examples from existing empirical studies about the effects of local TJ processes in various settings to demonstrate ways in which these types of violence may be perpetuated, or initiated in new forms through these processes, thus posing security risks. The framework is further developed through the elucidation of factors that may help to repair the consequences of direct and structural violence and/or hinder the likelihood of their repetition, thematically conceptualized as physical and psychological welfare and social justice (respective to direct and structural violence) that I suggest link to security benefits. The framework is intended to provide new perspectives on understanding how peacebuilding processes may both promote and prevent security from being realized at the local level following armed conflict.
Desert seismic signal denoising by 2D compact variational mode decomposition
Authors: Li Yue , Li Linlin , Zhang Chao 
Published: September 2019

AbstractNoise suppression and effective signal recovery are very important for seismic signal processing. The random noise in desert areas has complex characteristics due to the complex geographical environment; noise characteristics such as non-stationary, non-linear and low frequency. These make it difficult for conventional denoising methods to remove random noise in desert seismic records. To address the problem, this paper proposes a two-dimensional compact variational mode decomposition (2D-CVMD) algorithm for desert seismic noise attenuation. This model decomposes the complex desert seismic data into an finite number of intrinsic mode functions with specific directions and vibration characteristics. The algorithm introduces binary support functions, which can detect the edge region of the signal in each mode by penalizing the support function through the L1 and total variation (TV) norm. Finally, the signal can be reconstructed by the support functions and the decomposed modes. We apply the 2D-CVMD algorithm to synthetic and real seismic data. The results show that the 2D-CVMD algorithm can not only suppress desert low-frequency noise, but also recover the weak effective signal.
The Human Cost of the Weapons Trade: Small Arms Transfers and Recipient State Homicide
Authors: Martinez Machain Carla , Pickering Jeffrey 
Published: September 2019

AbstractEmpirical research has increasingly turned its attention to ways that international phenomena impact the human condition within countries. International influences have been shown to affect human rights, health, and quality of life within societies. They may also impact microlevel phenomena such as violent criminal behavior. In this study, we build on such recent scholarship and research that bridges the theoretical and empirical gap between international relations research and criminology. Our analysis examines the cross-national relationship between interstate small arms transfers and domestic homicide rates. We suspect that some proportion of weapons from the legal small arms trade find their way into the hands of societal actors and that a prevalence of firearms in society may be associated with elevated homicide rates. State strength should mitigate this relationship, as strong states should have greater ability to manage and to control legal arms shipments than their weaker counterparts. Cross-national empirical tests of small arms flows and homicide rates from 2000 to 2014 support our theoretical claims. They also demonstrate that legal small arms transfers impact only certain types of violent crimes.
Hosting Your Enemy: Accepting Refugees from a Rival State and Respect for Human Rights
Authors: Chu Tiffany S 
Published: September 2019

AbstractThis article argues that dynamics among rivals can affect how host states respond to refugees. Particularly, refugees from rival states can motivate host countries to promote inclusive action because they are exiled from an adversary. By treating refugees well and openly respecting their human rights, host states can, in effect, shame their rival, thereby undermining the adversary's legitimacy and discrediting the opposing government in the eyes of the international community. In the absence of a strategic rivalry, host governments do not have this incentive to support refugee human rights. Using statistical analyses, I find support for these hypotheses. In particular, the arrival of refugees from a neighboring rival state are associated with the strongest increase in respect for human rights within the host country, whereas refugees from a noncontiguous, nonrival state are related to a decrease in respect for human rights.
Detection of new methanol maser transitions associated with G358.93−0.03
Authors: MacLeod G C , Sugiyama K , Hunter T R , Quick J , Baan W , Breen S L , Brogan C L , Burns R A , Caratti o Garatti A , Chen X , Chibueze J O , Houde M , Kaczmarek J F , Linz H , Rajabi F , Saito Y , Schmidl S , Sobolev A M , Stecklum B , van den Heever S P , Yonekura Y 
Published: September 2019

ABSTRACT
We report the detection of new 12.178, 12.229, 20.347, and 23.121 GHz methanol masers in the massive star-forming region G358.93−0.03, which are flaring on similarly short time-scales (days) as the 6.668 GHz methanol masers also associated with this source. The brightest 12.178 GHz channel increased by a factor of over 700 in just 50 d. The masers found in the 12.229 and 20.347 GHz methanol transitions are the first ever reported and this is only the fourth object to exhibit associated 23.121 GHz methanol masers. The 12.178 GHz methanol maser emission appears to have a higher flux density than that of the 6.668 GHz emission, which is unusual. No associated near-infrared flare counterpart was found, suggesting that the energy source of the flare is deeply embedded.
PP4 phosphatase cooperates in recombinational DNA repair by enhancing double-strand break end resection
Authors: Villoria María Teresa , Gutiérrez-Escribano Pilar , Alonso-Rodríguez Esmeralda , Ramos Facundo , Merino Eva , Campos Adrián , Montoya Alex , Kramer Holger , Aragón Luis , Clemente-Blanco Andrés 
Published: September 2019

AbstractThe role of Rad53 in response to a DNA lesion is central for the accurate orchestration of the DNA damage response. Rad53 activation relies on its phosphorylation by Mec1 and its own autophosphorylation in a manner dependent on the adaptor Rad9. While the mechanism behind Rad53 activation has been well documented, less is known about the processes that counteract its activity along the repair of a DNA adduct. Here, we describe that PP4 phosphatase is required to avoid Rad53 hyper-phosphorylation during the repair of a double-strand break, a process that impacts on the phosphorylation status of multiple factors involved in the DNA damage response. PP4-dependent Rad53 dephosphorylation stimulates DNA end resection by relieving the negative effect that Rad9 exerts over the Sgs1/Dna2 exonuclease complex. Consequently, elimination of PP4 activity affects resection and repair by single-strand annealing, defects that are bypassed by reducing Rad53 hyperphosphorylation. These results confirm that Rad53 phosphorylation is controlled by PP4 during the repair of a DNA lesion and demonstrate that the attenuation of its kinase activity during the initial steps of the repair process is essential to efficiently enhance recombinational DNA repair pathways that depend on long-range resection for their success.
A Comparative Study of Fibromyalgia, Rheumatoid Arthritis, Spondyloarthritis, and Sjögren’s Syndrome; Impact of the Disease on Quality of Life, Psychological Adjustment, and Use of Coping Strategies
Authors: Bucourt Emilie , Martaillé Virginie , Goupille Philippe , Joncker-Vannier Isabelle , Huttenberger Brigitte , Réveillère Christian , Mulleman Denis , Courtois and Robert 
Published: September 2019

Abstract

Background
Fibromyalgia, rheumatoid arthritis, spondyloarthritis, and Sjögren’s syndrome are chronic rheumatic diseases with very different clinical characteristics, but which share symptoms such as pain and fatigue. The aim of the study was to examine the impact of the disease on psychological adaptation in fibromyalgia compared with other rheumatic diseases (rheumatoid arthritis, spondyloarthritis, and Sjögren’s syndrome).

Methods
In a multicenter study, 165 women with rheumatic diseases (48 with fibromyalgia, 47 with rheumatoid arthritis, 47 with spondyloarthritis, 23 with Sjögren’s syndrome) completed the General Health Questionnaire–28 (emotional distress), Fatigue Severity Scale (fatigue), Fibromyalgia Impact Questionnaire (impact of the disease), Coping Strategies Questionnaire (coping), and Mini International Neuropsychiatric Interview (comorbidity with DSM IV axis-I disorders). We used the Kruskal-Wallis test, Mann-Whitney U test, and chi2 test to compare comorbid anxiety and depressive disorders and to compare the impact of the disease on patients’ mental well-being and daily life and adjustment (coping strategies).

Results
Anxiety and depressive disorders were more common in fibromyalgia patients; they had higher scores on impact of the disease, physical symptoms, pain, and fatigue than rheumatoid arthritis patients and reported more fatigue than patients with spondyloarthritis. Overall, they used more maladaptive coping strategies (less use of distancing from pain than patients with rheumatoid arthritis and spondyloarthritis, less use of ignoring pain sensations, and more use of catastrophizing than those with rheumatoid arthritis). No differences were found between fibromyalgia and Sjögren’s syndrome on impact and adjustment.

Conclusions
Compared with other rheumatic diseases, fibromyalgia has a greater impact on daily life; patients have more difficulty adjusting to the disease and generally use poorer strategies to cope with pain.
The ‘Territory of the Union’ in EU Citizenship Law: Charting a Route from Parallel to Integrated Narratives
Authors: Shuibhne Niamh Nic 
Published: September 2019

Abstract
This paper examines the growing significance of the ‘territory of the Union’ in EU citizenship law and asks what it reveals about Union citizenship in the wider system of the EU legal order. In doing so, it builds on scholarship constructing the idea of ‘personhood’ in EU law by adding a complementary dimension of ‘place-hood’. The analysis is premised on territory as a place within—but also beyond—which particular legal qualities are both produced by and reflect shared objectives or values. In that respect, the paper offers a comprehensive ‘map’ of Union territory as a legal construct, with the aim of uncovering what kind of legal place the territory of the Union constitutes as well as the extent to which it is dis-connectable from the territories of the Member States. It also considers how Union territory relates to what lies ‘outside’. It will be shown that different narratives of Union territory have materialized in the case law of the Court of Justice. However, it is argued that these segregated lines of reasoning should be integrated, both to reflect and to progress a composite understanding of Union territory as a place in which concerns for Union citizens, for Member States, and for the system underpinning the EU legal order are more consistently acknowledged and more openly weighed.
Increased Fibrogenic Gene Expression in Multifidus Muscles of Patients With Chronic Versus Acute Lumbar Spine Pathology
Authors: Shahidi Bahar , Fisch Kathleen M. , Gibbons Michael C. , Ward Samuel R. 
Published: September 2019

Study Design.
Prospective observational study-basic science (Level 1).

Objective.
The aim of this study was to compare expression of functional groups of genes within the atrophic, myogenic, fibrogenic, adipogenic, and inflammatory pathways between paraspinal muscle biopsies from individuals with acute and chronic lumbar spine pathology.

Summary of Background Data.
Low back pain is a complex and multifactorial condition that affects a majority of the general population annually. Changes in muscle tissue composition (i.e., fatty and fibrotic infiltration) are a common feature in individuals with lumbar spine pathology associated with low back pain, which often results in functional loss. Understanding the molecular underpinnings of these degenerative changes in different phases of disease progression may improve disease prevention and treatment specificity.

Methods.
Intraoperative biopsies of the multifidus muscle were obtained from individuals undergoing surgery for acute (<6-month duration) or chronic (>6-month duration) lumbar spine pathology. Expression of 42 genes related to myogenesis, atrophy, adipogenesis, metabolism, inflammation, and fibrosis were measured in 33 samples (eight acute, 25 chronic) using qPCR, and tissue composition of fat, muscle, and fibrosis was quantified using histology.

Results.
We found that tissue composition of the biopsies was heterogeneous, resulting in a trend toward lower RNA yields in biopsies with higher proportions of fat (r <−0.39, P < 0.1). There were no significant differences in gene expression patterns for atrophy (P > 0.635), adipogenesis (P > 0.317), myogenesis (P > 0.320), or inflammatory (P > 0.413) genes after adjusting for the proportion of muscle, fat, and connective tissue. However, in the fibrogenesis pathway, we found significant upregulation of CTGF (P = 0.046), and trends for upregulation of COL1A1 (P = 0.061), and downregulation of MMP1 and MMP9 (P = 0.061) in the chronic group.

Conclusion.
There is increased fibrogenic gene expression in individuals with chronic disease when compared to acute disease, without significant differences in atrophic, myogenic, adipogenic, or inflammatory pathways, suggesting increased efforts should be made to prevent or reverse fibrogenesis to improve patient function in this population.

Level of Evidence: N/A
Granulocyte–Macrophage Colony-Stimulating Factor Inhalation Therapy for Severe Pulmonary Alveolar Proteinosis
Authors: Zhen Genshen , Li Duo , Jiang Jian , Weng Yibing 
Published: September 2019

Background:
Some patients with pulmonary alveolar proteinosis (PAP) still present with high recurrence rate after large-volume whole lung lavage (WLL). Granulocyte–macrophage colony-stimulating factor (GM-CSF) has been proved to be effective for PAP, but clinical research on GM-CSF inhalation therapy combined with WLL for severe PAP is rare in Asia.

Study Question:
This study aimed to investigate the clinical efficacy of GM-CSF inhalation combined with WLL in Chinese patients with PAP.

Study Design:
We performed regression analysis on 33 patients with severe PAP who underwent WLL alone or WLL combined with GM-CSF inhalation. The patients were put into 2 groups, WLL group and GM-CSF/WLL group.

Measures and Outcomes:
Physiologic, serologic, and radiologic features of the 2 groups at different time points after treatment and the recurrence rates at 1-year follow-up were compared.

Results:
There were no significant differences in lung function, blood gas analysis indices, and lung CT between the 2 groups after 1-week treatment (P > 0.05). After 3-month treatment, the GM-CSF/WLL group showed significantly faster improvement in FEV1%Pred (P = 0.028), FVC%Pred (P = 0.014), PaO2 (P = 0.022), PA-aO2 (P = 0.009), PaO2/FiO2 (P = 0.025), 6-minute walking test (P = 0.002), and lung CT parameters (P < 0.05) compared with the WLL group. The recurrence rate at the 1-year follow-up in the GM-CSF/WLL group (5.5%) was significantly higher than that in the WLL group (46.67%; P < 0.05).

Conclusions:
GM-CSF inhalation therapy combined with WLL is an effective treatment for patients with severe PAP, with further improvement in lung function at the base of WILL as well as reduction on re-WLL incidence.
Gastrointestinal Symptoms in Infants of Mothers With a Psychiatric History and the Role of Depression and Bonding
Authors: de Kruijff Ineke , Choenni Vandhana , Groeneweg Jasja T. , Vlieger Arine M. , Benninga Marc A. , Kok Rianne , Kamperman Astrid M. , Lambregtse‐van den Berg Mijke P. 
Published: September 2019

ABSTRACTObjectives:Gastroesophageal reflux (GER), excessive crying, and constipation are common gastrointestinal symptoms in infancy of multifactorial origin in which psychosocial stress factors play an important role. The aims of this observational study were to investigate the presence of gastrointestinal symptoms in infants of mothers with or without a history of a psychiatric disorder, their association with maternal depressive symptoms, and the possible mediating role of bonding.Methods:One hundred one mothers with a history of a psychiatric disorder and 60 control mothers were included. Infant gastrointestinal symptoms, maternal depressive symptoms, and mother‐infant bonding were assessed using validated questionnaires and diagnostic criteria at 1.5 months postpartum.Results:The mean total score on the Infant Gastroesophageal Reflux Questionnaire Revised reported in infants of mothers with psychiatric disorder (13.4 standard deviation 5.4) was significantly higher than that in infants of control mothers (10.8 standard deviation 5.4;P= .003). No significant differences were found in the presence of excessive crying (modified Wessel criteria and subjective experience) and constipation (ROME IV criteria) between both groups. Infant GER was associated with maternal depressive symptoms (P= 0.027) and bonding problems (P= <0.001). Constipation was related to maternal depressive symptoms (P= 0.045), and excessive crying (Wessel and subjective criteria) was associated with bonding problems (P= 0.022 andP= 0.002, respectively). The effect of maternal depressive symptomatology on infant GER symptoms and excessive crying was mediated by bonding problems.Conclusion:Maternal psychiatric history is associated with infant gastrointestinal symptoms, in which mother‐infant bonding is a mediating factor.