bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technological innovation and engineering practice of damage reduction mining and ecosystem restoration in open-pit coal mine
Authors: Li Quansheng , Li Xiaobin 
Published: December 2024

Abstract

Non-technical summary
To address the issues of declining groundwater levels and the degradation of soil ecological functions caused by open-pit coal mining in China. Based on theoretical analysis, laboratory experiments, on-site monitoring, mathematical modeling, and other means, the concept of coal ecological protection mining of ‘damage reduction mining, three-dimensional protection, systematic restoration’ is proposed. The mining concept has achieved remarkable ecological restoration effects, leading the scientific and technological progress of safe, efficient and green mining in open-pit coal mines.

Technical summary
The mechanism of damage propagation among ‘rock-soil-water’ ecological elements in open-pit coal mining was revealed. Adopting comprehensive damage-reducing mining technology throughout the entire stripping process, mining and drainage, shengli open-pit coal mine has doubled its production capacity, and reduced the land excavation and damage by 60 mu/year, reduced the mining area by 1,128 mu, and raised the groundwater level by 2.6–6 m, and the ecological restoration of the drainage field was advanced by more than 1 year. Adopting the three-dimensional water storage technology involves underground reservoirs, aquifer reconstruction, and near-surface distributed water storage units, baorixile open-pit mine has built the world's first open-pit underground water reservoir, with a water storage capacity of 1.22 million m3, and the speed of groundwater level restoration has been increased by more than 70%. By adopting the systematic restoration technology of geomorphology-soil-vegetation in the discharge site, the soil water content in the demonstration area has been increased by 52%, the survival rate of plants has been increased by 34%, and the vegetation coverage has been increased by more than 40%.

Social media summary
Damage-reducing mining and systematic ecological restoration in open-pit coal mining are essential for the safe, efficient and green development of coal.
Microseismicity Around Loki's Castle Hydrothermal Vent Field Reveals the Early Stages of Detachment Faulting at the Mohns‐Knipovich Ridge Intersection
Authors: Pilot Matthias , Lien Marie Jakobsen , Schlindwein Vera , Ottemöller Lars , Barreyre Thibaut 
Published: December 2024

AbstractAt slow to ultraslow spreading ridges, the limited melt supply results in tectonic accretion and the exhumation of mantle rocks. Melt supply is focused toward volcanic centers where magmatic accretion dominates. In areas where the ridges reorientate, both types of accretion can occur across the ridge axis with detachment faults developing on the inside corners and hydrothermal vent fields located in close proximity. Microseismicity studies improve the understanding of the tectonic processes at detachment faults and their interplay with hydrothermal vent systems, but are mostly limited to mature detachment faults or short deployment times. This study presents results from a ∼11 months ocean bottom seismometer deployment around the Loki's Castle hydrothermal vent field at the intersection of the slow to ultraslow spreading Mohns and Knipovich Ridge. We observe seismicity to be highly asymmetric with the majority of the plate divergence being accommodated by an emerging detachment fault at the inside corner of the intersection west of Loki's Castle. Seismic activity related to the detachment fault displays a distinct contrast, with continuous low‐magnitude events occurring at depth and episodic large‐magnitude events concentrated in clusters within the footwall. The detachment fault shows no significant roll‐over at shallow depths and the locus of spreading is located east of the detachment. These results suggest that the detachment fault west of Loki’s Castle is at an early development stage.
Improving Land Surface Temperature Estimation in Cloud Cover Scenarios Using Graph‐Based Propagation
Authors: Rolland Iain , Selvakumaran Sivasakthy , Ahmad Shaikh Shaikh Fairul Edros , Hamel Perrine , Marinoni Andrea 
Published: December 2024

AbstractLand surface temperature (LST) serves as an important climate variable which is relevant to a number of studies related to energy and water exchanges, vegetation growth and urban heat island effects. Although LST can be derived from satellite observations, these approaches rely on cloud‐free acquisitions. This represents a significant obstacle in regions which are prone to cloud cover. In this paper, a graph‐based propagation method, referred to as GraphProp, is introduced. This method can accurately obtain LST values which would otherwise have been missing due to cloud cover. To validate this approach, a series of experiments are presented using synthetically obscured Landsat acquisitions. The validation takes place over scenarios ranging from between 10% and 90% cloud cover across six urban locations. In presented experiments, GraphProp recovers missing LST values with a mean absolute error of less than 1.1°C, 1.0°C and 1.8°C in 90% cloud cover scenarios across the studied locations respectively.
Wave Decay by Submerged Rigid Vegetation Under Orthogonal Wave‐Current Conditions
Authors: Xu Zichen , Lei Jiarui 
Published: December 2024

AbstractCoastal vegetation has drawn significant attention as a nature‐based solution due to its role in wave attenuation. While the wave energy decay by vegetation has been studied under pure‐wave and co‐directional wave‐current conditions, little research has focused on orthogonal wave‐current conditions, which represent propagating waves and longshore currents in natural coastal environments. An analytical model is derived that incorporates various input parameters, including current‐to‐wave velocity ratio, wave height, wave period, water depth, and vegetation properties, to describe wave decay by rigid submerged vegetation under orthogonal wave‐current conditions. Force experienced by individual cylinders was measured, revealing that the drag coefficient of waves is applicable to orthogonal wave‐current conditions. Wave heights were measured along vegetation patches. The presence of an orthogonal current significantly enhanced wave decay by vegetation. The findings of this study underscore the more complicated orthogonal wave‐current conditions and provide valuable insights for future coastal protection strategies incorporating nature‐based solutions.
Ultraviolet NO and Visible O2 Nightglow in the Mars Southern Winter Polar Region: Statistical Study and Model Comparison
Authors: Soret L. , González‐Galindo F. , Gérard J.‐C. , Thomas I. R. , Ristic B. , Willame Y. , Vandaele A. C. , Hubert B. , Lefèvre F. , Daerden F. , Patel M. R. 
Published: December 2024

AbstractThe Mars NO and the O2 nightglow are produced by the recombination of atoms produced on the dayside by photodissociation and transported to the nightside. These emissions are tracers of the summer to winter pole dynamics in the upper Mars atmosphere. The UV‐visible (UVIS) channel of the Nadir and Occultation for MArs Discovery (NOMAD) spectrometer onboard Trace Gas Orbiter (TGO) is the first instrument able to simultaneously monitor both nightglow emissions. Observations by NOMAD/UVIS during the first part of the Martian year show that both the NO and O2 nightglow emissions are enhanced near the southern winter pole. Their mean brightnesses are 15 and 108 kR, respectively. These nightglow emissions generally occur between 30 and 60 km, the NO emitting layer being consistently located ∼10 km higher than the O2 nightglow layer. Numerical simulations with the Mars Planetary Climate Model (MPCM, v6.1) properly reproduce the nightglow brightness but tend to overestimate the NO peak altitude by ∼10 km. These results suggest that the atomic oxygen density is correctly predicted by the model but that the nitrogen density altitude distribution might not be properly modeled.
Endothelial Pim3 kinase protects the vascular barrier during lung metastasis
Authors: Santio Niina M. , Ganesh Keerthana , Kaipainen Pihla P. , Halme Aleksi , Seyednasrollah Fatemeh , Arbash Emad , Hänninen Satu , Kivelä Riikka , Carpen Olli , Saharinen Pipsa 
Published: December 2024

AbstractEndothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant organs. However, the molecular regulation of the ECs in the metastatic niche remains unclear. Here, we analyze using scRNA-Seq, the transcriptional reprogramming of lung ECs six hours after the arrival of melanoma cells in mouse lungs. We discover a reactive capillary EC cluster (rCap) that increases from general capillary ECs in response to infiltrating cancer cells. rCap is enriched for angiogenic and inflammatory pathways and is also found in human lung datasets. The JAK-STAT activated oncogenic Pim3 kinase is a marker of rCap, being upregulated in spontaneous metastasis models. Notably, PIM inhibition increases vascular leakage and metastatic colonization and impairs the EC barrier by decreasing the junctional cadherin-5 and catenins α, β and δ. These results highlight the pulmonary endothelium’s plasticity and its protection by PIM3, which may impair the efficacy of PIM inhibitors in cancer therapies.
Early administration of anamorelin improves cancer cachexia in gastrointestinal cancer patients: an observational study
Authors: Matsumoto Toshihiko , Cho Sien , Nakasya Akio , Nagai Hiroki , Satake Hironaga , Yasui Hisateru 
Published: December 2024

AbstractTo report the efficacy of anamorelin in patients with colorectal and gastric cancer with cachexia and in those receiving systemic chemotherapy. We retrospectively collected real-world data from patients diagnosed with colorectal and gastric cancers experiencing cachexia who were treated with anamorelin. We evaluated the efficacy of treatment by measuring the improvements in appetite and body weight (BW) gain. Between June 2021 and October 2022, 43 cancer patients with cachexia—23 with gastric cancer and 20 with colorectal cancer—were treated with anamorelin. Median observation period was 7.3 months. The participants were 25 males with median age of 71 years and median BMI of 19.7. The ECOG PS distribution was 4, 33, 6 for grades 0, 1, and 2, respectively. Seven patients received supportive care only, while 36 received anamorelin with chemotherapy. Thirty-four had received chemotherapy previously (≤ 2 regimens) and nine had received ≥ 3 regimens. Median anamorelin treatment duration was 2.8 months; overall survival was 7.3 months. After 3 weeks, 24 experienced appetite improvement and 21 gained weight; after 12 weeks, 20 experienced appetite improvement and 15 gained weight. Multivariate analysis showed that anamorelin treatment before second-line chemotherapy and colorectal cancer correlated with appetite improvement and weight gain at 3 weeks. In the univariate analysis, anamorelin treatment before second-line chemotherapy correlated with weight gain at 12 weeks and with improved overall survival in patients with weight gain at 12 weeks. Early anamorelin treatment contributes to appetite improvement and BW gain in colorectal and gastric cancers with cachexia.
A fully automated morphological analysis of yeast mitochondria from wide-field fluorescence images
Authors: Vojtová Jana , Čapek Martin , Willeit Sabrina , Groušl Tomáš , Chvalová Věra , Kutejová Eva , Pevala Vladimír , Valášek Leoš Shivaya , Rinnerthaler Mark 
Published: December 2024

AbstractMitochondrial morphology is an important parameter of cellular fitness. Although many approaches are available for assessing mitochondrial morphology in mammalian cells, only a few technically demanding and laborious methods are available for yeast cells. A robust, fully automated and user-friendly approach that would allow (1) segmentation of tubular and spherical mitochondria in the yeast Saccharomyces cerevisiae from conventional wide-field fluorescence images and (2) quantitative assessment of mitochondrial morphology is lacking. To address this, we compared Global thresholding segmentation with deep learning MitoSegNet segmentation, which we retrained on yeast cells. The deep learning model outperformed the Global thresholding segmentation. We applied it to segment mitochondria in strain lacking the MMI1/TMA19 gene encoding an ortholog of the human TCTP protein. Next, we performed a quantitative evaluation of segmented mitochondria by analyses available in ImageJ/Fiji and by MitoA analysis available in the MitoSegNet toolbox. By monitoring a wide range of morphological parameters, we described a novel mitochondrial phenotype of the mmi1Δ strain after its exposure to oxidative stress compared to that of the wild-type strain. The retrained deep learning model, all macros applied to run the analyses, as well as the detailed procedure are now available at https://github.com/LMCF-IMG/Morphology_Yeast_Mitochondria.
BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling
Authors: Zhao Chengzhu , Inada Yoshiko , Motoike Souta , Kamiya Daisuke , Hino Kyosuke , Ikeya Makoto 
Published: December 2024

Abstract
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder presenting with progressive heterotopic ossification (HO) in soft tissues. Early-stage FOP is characterized by recurrent episodes of painful tissue swelling (flare-ups), with numerous proliferation-activated mesenchymal stromal cells (MSCs) subsequently causing HO. However, the mechanisms underlying flare-up progression remain unclear. In this study, we evaluated the proliferation of MSCs obtained from FOP patient-derived induced pluripotent stem cells (FOP-iPSCs) to elucidate the mechanisms underlying flare-ups and found that bone morphogenetic protein (BMP)-9 mediated enhanced proliferation by abnormal activation of transforming growth factor (TGF)-β signaling pathway in MSCs from FOP-iPSCs. In FOP model mice, elevated BMP-9 levels correlated with elevated phosphorylation of SMAD2/3 and increased cellular proliferation in the affected tissues, while systemic BMP-9 neutralization and knockout mitigated flare-ups and HO. Thus, BMP-9 aberrantly transduces TGF-β signaling and induces fibroproliferation, initiating flare-ups. This study provides novel insights into the development of future FOP therapies.
Concurrent Cognitive Task Alters Postural Control Performance of Young Adults With Unilateral Cochlear Implants
Authors: Orhan Emre , Batuk İsa Tuncay , Batuk Merve Ozbal 
Published: December 2024

Purpose:
The aim of this study was to investigate the balance performances of young adults with unilateral cochlear implants (CIs) in a dual-task condition.

Method:
Fifteen young adults with unilateral CIs and 15 healthy individuals were included in the study. The balance task was applied using the Sensory Organization Test via Computerized Dynamic Posturography. The Backward Digit Recall task was applied as an additional concurrent cognitive task. In the balance task, participants completed four different conditions, which gradually became more difficult: Condition 1: fixed platform, eyes open; Condition 3: fixed platform, eyes open and visual environment sway; Condition 4: platform sway, eyes open; Condition 6: platform sway, eyes open and visual environment sway. To evaluate the dual-task condition performance, participants were given cognitive and motor tasks simultaneously.

Results:

Visual (
p
= .016), vestibular (
p
< .001), and composite balance scores (
p
< .001) of CI users were statistically significantly lower than the control group. Condition 3 (
p
= .003), Condition 4 (
p
= .007), and Condition 6 (
p
< .001) balance scores of CI users in the single-task condition were statistically significantly lower than controls. Condition 6 (
p
< .001) balance scores of CI users in the dual-task condition were statistically significantly lower than the control group. Condition 1 score (
p
= .002) of the CI users in the dual-task condition showed a statistically significant decrease compared to the balance score in the single-task condition, while the Condition 6 score (
p
= .011) in the dual-task condition was statistically significantly higher than the balance score in the single-task condition.

Conclusions:
The balance performance of individuals with CIs in the dual-task condition was worse than typical healthy individuals. It can be suggested that dual-task performances should be included in the vestibular rehabilitation process in CI users in the implantation process in terms of balance abilities in multitasking conditions and risk of falling.
COVID-19 and Hearing: Pure Tone, Speech, and High-Frequency Audiometry
Authors: Yildirim Gökay Nuriye , Cesur Aksoy Gökçen , Karamert Recep 
Published: December 2024

Abstract
Background Coronavirus disease 2019 (COVID-19) and its effects on hearing performance have been an interesting topic for researchers recently.
Purpose The objective of this study was to assess the audiological profile of people affected by COVID-19 and also to compare them with a control group who has never had COVID-19.
Research Design An experimental study.
Study Sample The study group consisted of 54 participants, aged 18 to 60, who were diagnosed with COVID-19 by polymerase chain reaction and recovered at least 2 months prior to audiological assessment. The control group consisted of 60 subjects in the same age range who did not have a history of COVID-19 or hearing loss.
Data Collection and Analysis Post-COVID audiological data were compared. The pre-COVID-19 audiological data of 43 subjects in the study group were also compared with their post-COVID-19 data. All participants were evaluated with pure tone audiometry, acoustic immittancemetry, speech audiometry, and high-frequency audiometry.
Results Pure tone hearing thresholds, speech recognition and discrimination scores, and high-frequency hearing thresholds were all statistically different between the study and control groups (p < 0.05). There were statistically significant differences between the study group's pure tone hearing thresholds before and after COVID-19 (p < 0.05).
Conclusion COVID-19 can adversely affect hearing performance. Further studies including auditory brainstem response, otoacoustic emissions, and similar cross-check tests are needed to reveal further effects of COVID-19 on hearing.
Magnetic Compression Anastomosis for Treatment of Post-cholecystectomy Bile Duct Injury Related Biliary Strictures
Authors: Garg Parul , Sharma Malay 
Published: December 2024

AbstractThe management of post-cholecystectomy biliary strictures remains challenging. While endoscopic and percutaneous biliary procedures have shown high success rates in treating these benign biliary strictures, sometimes the guidewire cannot be negotiated across the stricture, making the stricture refractory to management by the endoscopic or percutaneous route. Magnetic compression anastomosis is a nonsurgical alternative used on the endoscopic and percutaneous biliary platform to create a passage across the refractory biliary stricture. We report three cases of uncrossable bile duct strictures managed with magnetic compression anastomosis. This report highlights the utility of a relatively simple technique for managing complex problems.
White Matter Dissection: Lessons from the United Kingdom National Neuroanatomy Undergraduate Competition 2023
Authors: Gardee Ameerah , Goonewardena Eranga , Lub Sytske , Ashraf Mohammad , Ismahel Hassan , Chaudhary Attika , Al-Salloum Laulwa Nasser , Border Scott 
Published: December 2024

Abstract
Objective This narrative highlights a student-led initiative that explored white matter dissection techniques within the framework of the National Undergraduate Neuroanatomy Competition 2023.
Materials and Methods The project aimed to enhance neuroanatomical education by developing a novel approach to dissection that deviates from the traditional Klingler’s method. Instead, it incorporated contemporary techniques, including diffusion tensor imaging and other radiological tools, to ensure greater anatomical precision and enrich the learning experience.
Results The dissections focused on key white matter structures, such as the uncinate fasciculus and the inferior longitudinal fasciculus, and outlined a step-by-step methodology for creating high-quality specimens. These specimens are designed to serve as educational resources, particularly for students with limited access to formal neuroanatomy courses.
Conclusion This study emphasizes the critical role of hands-on dissection in neuroanatomy education, showcasing its ability to enhance student engagement, deepen anatomical understanding, and inspire interest in clinical neuroscience careers. By introducing innovative educational tools and methodologies, this initiative makes a meaningful contribution to addressing the issue of “neurophobia” in medical education.
How do elite core actors assess trust in national and EU authorities? The varying role of generalised trust at different governmental levels
Authors: Kappler Moritz , Schomaker Rahel , Guaschino Edoardo , Verhoest Koen 
Published: December 2024

AbstractIn this paper, we position generalised trust as central to the debate on elites’ assessments of trust in EU multi-level governance. We leverage one of the most influential factors in explaining political trust in single-government studies to understand variations in trust towards political authorities at various levels. Departing from existing studies, we hypothesise the dual nature of generalised trust: while it influences how individuals assess their trust in political authorities, its impact varies depending on different degrees of perceived similarity of these authorities at either the national or the EU level. To test our hypotheses, we conducted an elite vignette experiment involving 567 decision-makers from public and private stakeholders within regulatory regimes in eight countries. The results reveal a significant positive effect of generalised trust on political trust when evaluating a national-level regulatory agency. However, trust assessments of EU-level regulatory agencies appear to be largely unaffected by generalised trust levels. Furthermore, we observed notable differences in trust assessment between private and public stakeholders, reinforcing our argument that similarity and community belonging underlie the influence of generalised trust on political trust. Our study suggests that EU-level political authorities may derive less benefit from high levels of generalised trust, compared to national political authorities. However, in instances where generalised trust is low, political authorities at the EU level have comparatively more opportunities to cultivate trust in them.
Trapped in the grey zone: NATO-CSDP relations in a new era of European security governance
Authors: Helferich John 
Published: December 2024

AbstractThis paper critically examines the complementarity of NATO and the EU’s Common Security and Defence Policy (CSDP), proposing a reassessment of their roles to explore potential reforms. It contributes to the forum on “Organising European Security” by tracing the historical origins of issues, such as “consensus escapism”, that challenge European security governance. In addressing this issue, the paper explores three scenarios for institutional reform: abolishing the CSDP, integrating it into NATO, or pursuing European strategic autonomy. The analysis shows that while such reforms could reduce strategic ambiguities, they might also undermine crucial community maintenance functions, especially those fulfilled by the CSDP for the EU. Following the Ukraine invasion, the structural parameters of NATO/CSDP relations have remained largely unchanged; however, the analysis indicates an emerging dynamic of a “compartmentalised geographic approach” to strengthening European security. This approach, while not eliminating NATO-CSDP ambiguities, may allow for a viable balance of community maintenance and power projection in a changing security landscape.