bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open Liver Resection, Laparoscopic Liver Resection, and Percutaneous Thermal Ablation for Patients with Solitary Small Hepatocellular Carcinoma (≤30 mm): Review of the Literature and Proposal for a Therapeutic Strategy
Authors: Viganò Luca , Laurenzi Andrea , Solbiati Luigi , Procopio Fabio , Cherqui Daniel , Torzilli Guido 
Published: June 2018

<b><i>Background:</i></b> Patients with a single hepatocellular carcinoma (HCC) ≤3 cm and preserved liver function have the highest likelihood to be cured if treated. The most adequate treatment methods are yet a matter that is debated. <b><i>Methods:</i></b> We reviewed the literature about open anatomic resection (AR), laparoscopic liver resection (LLR), and percutaneous thermal ablation (PTA). <b><i>Results:</i></b> PTA is effective as resection for HCC &#x3c; 2 cm, when they are neither subcapsular nor perivascular. PTA in HCC of 2–3 cm is under evaluation. AR with the removal of the tumor-bearing portal territory is recommended for HCC &#x3e; 2 cm, except for subcapsular ones. In comparison with open surgery, LRR has better short-term outcomes and non-inferior long-term outcomes. LLR is standardized for superficial limited resections and for left-sided AR. <b><i>Conclusions:</i></b> According to the available evidences, the following therapeutic proposal can be advanced. Laparoscopic limited resection is the standard for any subcapsular HCC. PTA is the first-line treatment for deep-located HCC &#x3c; 2 cm, except for those in contact with Glissonean pedicles. Laparoscopic AR is the standard for deep-located HCC of 2–3 cm of the left liver, while open AR is the standard for deep-located HCC of 2–3 cm in the right liver. HCC in contact with Glissonean pedicles should be scheduled for resection (open or laparoscopic) independent of their size. Liver transplantation is reserved to otherwise untreatable patients or as a salvage procedure at recurrence.
Reduced Myocardial Flow Reserve by Positron Emission Tomography Predicts Cardiovascular Events After Cardiac Transplantation
Authors: Konerman Matthew C. , Lazarus John J. , Weinberg Richard L. , Shah Ravi V. , Ghannam Michael , Hummel Scott L. , Corbett James R. , Ficaro Edward P. , Aaronson Keith D. , Colvin Monica M. , Koelling Todd M. , Murthy Venkatesh L. 
Published: June 2018

Background:
We evaluated the diagnostic and prognostic value of quantification of myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients.

Methods and Results:

We retrospectively identified orthotopic heart transplant patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was the composite of cardiovascular death, acute coronary syndrome, coronary revascularization, and heart failure hospitalization. Cox regression was used to evaluate the association of MFR with the primary outcome. The relationship of MFR and cardiac allograft vasculopathy severity in patients with angiography within 1 year of PET imaging was assessed using Spearman rank correlation and logistic regression. A total of 117 patients (median age, 60 years; 71% men) were identified. Twenty-one of 62 patients (34%) who underwent angiography before PET had cardiac allograft vasculopathy. The median time from orthotopic heart transplant to PET imaging was 6.4 years (median global MFR, 2.31). After a median of 1.4 years, 22 patients (19%) experienced the primary outcome. On an unadjusted basis, global MFR (hazard ratio, 0.22 per unit increase; 95% confidence interval, 0.09–0.50;
P
<0.001) and stress myocardial blood flow (hazard ratio, 0.48 per unit increase; 95% confidence interval, 0.29–0.79;
P
=0.004) were associated with the primary outcome. Decreased MFR independently predicted the primary outcome after adjustment for other variables. In 42 patients who underwent angiography within 12 months of PET, MFR and stress myocardial blood flow were associated with moderate–severe cardiac allograft vasculopathy (International Society of Heart and Lung Transplantation grade 2–3).

Conclusions:
MFR assessed by cardiac rubidium-82 PET imaging is a predictor of cardiovascular events after orthotopic heart transplant and is associated with cardiac allograft vasculopathy severity.
Review of the genus Promalactis Meyrick, 1908 (Lepidoptera: Oecophoridae) III. The trilineata species group, with descriptions of four new species
Authors: WANG SHUXIA , JIA YANYAN 
Published: June 2018

The trilineata species group of the genus Promalactis Meyrick, 1908 is proposed for the first time based on the forewing patterns. A total of 36 species are included, four of which are described as new: P. aggregata sp. nov., P. apicifurcellata sp. nov., P. stenitubilaris sp. nov. and P. albipedalis sp. nov. Photographs of adults and genitalia of the new species are provided. A checklist of the other described species belonging to this group is given with original citations.
The Impact of Tropical Precipitation on Summertime Euro-Atlantic Circulation via a Circumglobal Wave Train
Authors: O’Reilly Christopher H. , Woollings Tim , Zanna Laure , Weisheimer Antje 
Published: June 2018

AbstractThe influence of tropical precipitation variability on summertime seasonal circulation anomalies in the Euro-Atlantic sector is investigated. The dominant mode of the maximum covariance analysis (MCA) between the Euro-Atlantic circulation and tropical precipitation reveals a cyclonic anomaly over the extratropical North Atlantic, contributing to anomalously wet conditions over western Europe and dry conditions over eastern Europe and Scandinavia (in the positive phase). The related mode of tropical precipitation variability is associated with tropical Pacific SST anomalies and is closely linked to the El Niño–Southern Oscillation (ENSO). The second MCA mode consists of weaker tropical precipitation anomalies but with a stronger extratropical signal that reflects internal atmospheric variability. The teleconnection mechanism is tested in barotropic model simulations, which indicate that the observed link between the dominant mode of tropical precipitation and the Euro-Atlantic circulation anomalies is largely consistent with linear Rossby wave dynamics. The barotropic model response consists of a circumglobal wave train in the extratropics that is primarily forced by divergence anomalies in the eastern tropical Pacific. Both the eastward and westward group propagation of the Rossby waves are found to be important in determining the circulation response over the Euro-Atlantic sector. The mechanism was also analyzed in an operational seasonal forecasting system, ECMWF’s System 4. While System 4 is well able to reproduce and skillfully forecast the tropical precipitation, the extratropical circulation response is absent over the Euro-Atlantic region, which is likely related to biases in the Asian jet stream.
WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway
Authors: Xia Yonghua , Chang Xiao , Lian Shi , Zhu Wei 
Published: June 2018

Objectives WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) has been implicated in tumor progression. We aimed to investigate the role of WWP1 in cutaneous squamous cell carcinoma (CSCC). Methods WWP1 gene and protein levels were detected using semi-quantitative reverse transcription-polymerase chain reaction, immunohistochemistry and western blotting. The effects of WWP1 on cell cycle, apoptosis, cell migration and invasion were examined by flow cytometry, wound healing and Transwell assays, respectively. The antitumor efficacy of WWP1 small interfering RNA was determined in CSCC tumor xenografts in mice. Results WWP1 expression was significantly higher in CSCC tissues and cells than in normal skin and cells, respectively. WWP1 expression was significantly associated with histological grade, invasion depth and lymph node metastasis in patients with CSCC. High expression predicted metastatic potential and an unfavorable prognosis. WWP1 downregulation suppressed tumor growth in vitro and in vivo, reduced cell migration and invasion, arrested the cell cycle in G0/G1 and induced apoptosis in A431 cells. WWP1 depletion also decreased phosphorylated signal transducer and activator of transcription 3 (STAT3), matrix metalloproteinase-2, cyclin D1 and Bcl-2, but did not affect total STAT3. Conclusions WWP1 is a potential target for the diagnosis, prognosis and therapy of patients with CSCC.
Diagnostic value of a simplified screening test for metabolic syndrome in a Dutch patient cohort with schizophrenia spectrum disorders
Authors: Amzand Salcey G , Luteijn Bert L , van der Ven Els , Bogers Jan P , Selten Jean-Paul 
Published: June 2018

Objective: The aim of this study was to establish the specificity and sensitivity of a simplified screening test based on diastolic blood pressure and waist circumference for predicting metabolic syndrome. Method: Demographic, anthropometric (waist circumference and systolic and diastolic blood pressure) and laboratory (triglyceride, high-density lipoprotein and fasting glucose) data were collected from a large cohort of Dutch patients with a schizophrenia spectrum disorder in order to determine whether patients fulfilled the Western criteria of the International Diabetes Federation (IDF) for metabolic syndrome. The sensitivity, specificity, likelihood ratio of a positive or negative test outcome and positive and negative predictive values of the simplified test (only waist circumference and diastolic blood pressure) were calculated. Results: Of 252 recruited patients, 55% met the IDF criteria for metabolic syndrome. The sensitivity and the specificity of the simplified test were 65% and 85%, respectively. The likelihood ratios of positive and negative test outcomes were 4.35 and 0.41, respectively, and the positive and negative predictive values were 87% and 67%, respectively. Conclusion: This simplified screening test did not have diagnostic validity for metabolic syndrome in a Dutch cohort of patients with schizophrenia spectrum disorder.
Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease
Authors: Lenglet Marion , Robriquet Florence , Schwarz Klaus , Camps Carme , Couturier Anne , Hoogewijs David , Buffet Alexandre , Knight Samantha J. L. , Gad Sophie , Couvé Sophie , Chesnel Franck , Pacault Mathilde , Lindenbaum Pierre , Job Sylvie , Dumont Solenne , Besnard Thomas , Cornec Marine , Dreau Helene , Pentony Melissa , Kvikstad Erika , Deveaux Sophie , Burnichon Nelly , Ferlicot Sophie , Vilaine Mathias , Mazzella Jean-Michaël , Airaud Fabrice , Garrec Céline , Heidet Laurence , Irtan Sabine , Mantadakis Elpis , Bouchireb Karim , Debatin Klaus-Michael , Redon Richard , Bezieau Stéphane , Bressac-de Paillerets Brigitte , Teh Bin Tean , Girodon François , Randi Maria-Luigia , Putti Maria Caterina , Bours Vincent , Van Wijk Richard , Göthert Joachim R. , Kattamis Antonis , Janin Nicolas , Bento Celeste , Taylor Jenny C. , Arlot-Bonnemains Yannick , Richard Stéphane , Gimenez-Roqueplo Anne-Paule , Cario Holger , Gardie Betty 
Published: June 2018

Key Points
Mutations in a VHL cryptic exon may be found in patients with familial erythrocytosis or VHL disease. Synonymous mutations in VHL exon 2 may induce exon skipping and cause familial erythrocytosis or VHL disease.
Medically unexplained syndromes: irritable bowel syndrome, fibromyalgia and chronic fatigue
Authors: Luty Jason 
Published: June 2018

SUMMARYThis is a review of three of the more common medically unexplained syndromes that present for treatment to liaison psychiatry services in general medical hospitals: chronic fatigue syndrome, fibromyalgia and irritable bowel syndrome. The three are interrelated, extremely disabling and comorbid mood disorders are frequent. In general, treatment, whether psychological or medical, has very modest impact. The disputed classification of medically unexplained syndromes is also reviewed. There is a clear gulf between the views and experiences of patients with these syndromes and the medical establishment. In this article I summarise give the evidence for pharmacological, psychosocial and ‘alternative’ or ‘complementary’ interventions for a range of disorders, about which there is some dispute. I leave it to the reader to decide which interventions hold the most promise.LEARNING OBJECTIVES•To become aware of the high prevalence of medically unexplained syndromes•To review the effectiveness of treatment of medically unexplained syndromes•To be familiar with the conflict between health professionals and patients and the difficulty this continues to createDECLARATION OF INTERESTNone.
Confined Synthesis of Coordination Frameworks inside Double-Network Hydrogel for Fabricating Hydrogel-Based Water Pipes with High Adsorption Capacity for Cesium Ions
Authors: Zhao Pan , Zhang Wei , Kaneti Yusuf Valentino , Azhar Alowasheeir , Alshehri Abdulmohsen Ali , Yamauchi Yusuke , Hu Ming 
Published: June 2018

AbstractHydrogel-based water pipes which can capture ionic contaminants are a promising solution for achieving efficient water treatment. However, the fabrication of such unique water pipes as an ion-harvester remains a challenge. In this work, we have fabricated this kind of water pipe through the confined synthesis of coordination frameworks inside a double-network PAAm/PAMPS hydrogel. The hydrogel could trigger the partial decomposition and reduction of K3[Fe(CN)6] upon heating. The released Fe3+/Fe2+ ions could react with the [Fe(CN)6]4−/[Fe(CN)6]3−, finally producing Prussian Blue coordination frameworks inside the hydrogel. The resulting composite exhibited a high capacity for Cs+ ions (397 mg g−1 in 10 minutes) by taking the coupling effect between the cation-selective hydrogel and the coordination frameworks. By shaping this composite into water pipes, Cs+ ions present in the contaminated water could be captured by the pipe wall. The proposed strategy will be useful, providing a potential method for fast treatment of aqueous nuclear waste.
Concurrent validity between a portable force plate and instrumented walkway when measuring limits of stability
Authors: Berg-Poppe Patti , Cesar Guilherme M. , Tao Hanz , Johnson Cal , Landry Jessica 
Published: June 2018

Background: Balance deficits underlie a number of disorders and can exacerbate the primary condition if not addressed. Limits of stability, usually evaluated via force plates, can provide valuable information about balance and associated insufficiencies. A portable instrumented mat used clinically to measure gait characteristics has recently shown potential for limits of stability assessment. The mat also affords the ability to measure proactive control of limits of stability and quantitative information specific to stepping when limits of stability are exceeded. This study examined concurrent validity between the Bertec BalanceCheck Force Plate, an established instrument for measuring limits of stability, and the ProtoKinetics Zeno Walkway. Methods: A total of 51 adults (mean age 25.5 [standard deviation: 7.5] years; 72.5% female) without known disabilities leaned as far as possible in anterior, posterior, rightward and leftward directions while standing in narrow and natural stances on the force plate and walkway. Results: Pearson correlations for the force plate and walkway showed significant positive agreement for all directions tested in the narrow (r range = 0.657–0.878) and natural stances (r range: 0.928–0.936). Conclusions: Findings lend evidence of instrument interchangeability when measuring limits of stability. The results demonstrate evidence of concurrent and construct validity in support of the use of the Zeno Walkway as a measure of limits of stability.
<strong>Butterfly (Lepidoptera: Rhopalocera) diversity in relation to habitat utilization at Jagannath Kishore College, Purulia, West Bengal (India)</strong>
Authors: DAS DIPANWITA 
Published: June 2018

Documentation of butterfly diversity is necessary for ecosystem management both at the local and the global scales. The varied types of functional role of the butterflies qualify them for conservation and thus sustenance of the ecosystem services. Information about the biodiversity of Purulia district as well as arid regions of Chota Nagpur Plateau is insufficient and this necessitates to investigate about the butterfly diversity of Purulia which will provide subsequent information for ecosystem management. On the basis of this proposition, the present study was carried out in the campus of Jagannath Kishore College, Purulia, West Bengal (India). The species richness, species diversity, seasonal variation and habitat utilisation by the butterflies were studied for a period of one year between February 2016 and January 2017 with photographic documentation. A total of seventy-one butterfly species under five families were encountered, of which, the family Nymphalidae represented highest number of species. The butterfly species richness was lower in summer probably due to the scarcity of water, but during monsoon and post-monsoon seasons water availabitity boost up the vegetation and therefore species richness increased to its maximum. Among the different species, Eurema hecabe was the most abundant species throughout the year followed by Leptosia nina, Danaus chrysippus and Catopsilia pomona. In the study area, thirty-one species of herbs and shrubs were identified as nectaring plants for adult butterflies. Among them, Tridax procumbens, Lantana camara, Alternanthera sessilis and Tagetes sp. were recognized as the preferred nectaring plants based on the number of butterflies visiting them. As an effort for conservation of the butterflies, the information on the plants and the species avaialble in the concerned region may be used further. However, long term monitoring of the concerned region is recommended to understand the changes in the environmental quality as reflected through the variations in the butterfly species assemblages.
Prevalence of obesity among urban and rural school going adolescents of Vadodara, India: a comparative study
Authors: Pathak Sunil , Modi Prashant , Labana Urmil , Khimyani Priya , Joshi Amruta , Jadeja Riddhi , Pandya Meghavi 
Published: June 2018

Background: Obesity is a major global problem among children. India has paradox of having both undernutrition and obesity as a major problem. This epidemic of obesity is also affecting rural population. It has both short and long term adverse health outcome.Methods: The present study is a cross-sectional, observational and questionnaire-based study conducted in urban and rural school going adolescents.Results: 188 subjects (89 rural and 99 urban school) school were enrolled. 17.6%(33), 20.2%(38), 59%(111) and 3.2%(6) children were obese, overweight, normal and underweight respectively. 65.22% of urban males & 62.26% females were either obese or overweight as compared to 15.78% of rural males and 3.92% females (p<0.0001). OR was 17.7 (95% CI of 7.6 to 40.7) in favor of urban residence. Statistically significant (p<0.05) differences is found in term of annual income of family, frequency of physical training sessions conducted in schools, frequency of restaurant & school canteen food. No statistically significant association was found between two categories (higher BMI & normal BMI) with other factors viz. breakfast before school, liking for fast food, involvement in outdoor sports, operating gadgets during meals and having obese family members.Conclusions: Obesity and overweight is more prevalent in urban adolescent. There is no difference among male and female group. There is tendency of high frequency of obesity and overweight among those adolescents who have higher annual family income, frequency of restaurant and school canteen food and lesser frequency of physical training sessions conducted in schools.
Digital Business: The Transition into New Age Dealing; Emphasizing Inputs from Cloud Computing and Big Data—An Indian Case
Authors: Paul P. K. , Bhuimali A. , Tiwary Kalishankar , Aithal P. S. , Rajesh R. 
Published: June 2018

<p class="lego-element">Business in today’s age changing rapidly, there are many reasons for this kind of transition of business houses and corporate bodies. Moreover, people in today’s age are using more online and digital means for the business and thus overall business systems are emphasize digital sources of revenue as well as digital channels. The concept of creation and dependencies of tools and technologies for financial economics systems is called Digital Economy and the growth of this leads to the development and familiarity with digital products and services among the service seekers and these ultimately are resulted in newer and competitive advantages in the digital space and system. Digital technology and its nature is also changing and has also challenged the existing business models. Here the key driving forces are included the capacity of innovation as well as the public availability of IT in different way. Digital business today is not a concept but it is about that stage of IT and Computing applications in different models viz. in marketing, ICT, social, business houses, healthcare, education and so on. Importantly these models may be seen as the convergence of technologies/ fully connected/integrated stage. In today’s age business is not only seen with computing and digital means but the traditional business systems also getting benefits from the ICT and here among the emerging names, few important include cloud computing, the Internet of Things, mobile and Big Data. It is important to note that this paper emphasizes the recent applications and role of Cloud Computing and Big Data in Business with a case of India. Moreover different financial aspects have also been described and analysed.</p>
Improving Separation of Oil and Water With a Novel Coalescing Centrifugal Pump
Authors: Husveg R.. , Husveg T.. , van Teeffelen N.. , Ottestad M.. , Hansen M. R. 
Published: June 2018

Summary
A novel centrifugal pump that increases oil-droplet sizes in produced water has been developed. This paper investigates a concept of pumping-pressure optimization, with respect to downstream separation efficiency, for the new pump. The investigation shows that the coalescing centrifugal pump always increased the separation efficiency of a downstream hydrocyclone. Furthermore, it is shown that the pumping pressure can be adjusted to maximize the improvement. Experimental results demonstrate how pumping conditions that minimize the volume fraction of droplets with a diameter smaller than the cut size of the hydrocyclone maximize the separation efficiency. Finally, it is demonstrated how the concept of pumping-pressure optimization can be implemented in a typical produced-water-treatment plant.
Parsimonious modelling of winter season rainfall incorporating reanalysis climatological data
Authors: Garthwaite Andrew P. , Ramesh N. I. 
Published: June 2018

Abstract
Several Markov modulated Poisson process (MMPP) models are developed to describe winter season rainfall with parsimonious parameter use. We propose a methodology for determining the best form of seasonal model for fine-scale rainfall within a MMPP framework. Of those proposed here, a model with a fixed transition rate is shown to be superior over the other MMPP models considered. The model is expanded to include covariate data for sea-level air pressure, relative humidity, and temperature using reanalysis data over 14 years from the coordinates covering the Bracknell rainfall collection site in England. Results are compared using the likelihood ratio test and the second-order properties of aggregated rainfall.