bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits and Disadvantages of Individuals’ Multiple Team Membership: The Moderating Role of Organizational Tenure
Authors: van de Brake Hendrik J. , Walter Frank , Rink Floor A. , Essens Peter J. M. D. , van der Vegt Gerben S. 
Published: October 2019

AbstractMany employees in today’s organizations are involved in more than one team at the same time. Building on the challenge‐hindrance stressor framework, this study investigates potential benefits and disadvantages of such multiple team membership (MTM) for individual employees. Furthermore, we extend this framework with insights from the job demands‐resources model to propose that, depending on an employee’s organizational tenure, individual MTM will differentially shape his or her perceptions of work challenge and role ambiguity, subsequently influencing the employee’s job performance and absenteeism. We tested our conceptual model using time‐lagged multi‐source data from a large organization of applied research (N = 1211). Our results demonstrate that, for employees with relatively low organizational tenure, MTM was negatively associated with perceived work challenge and positively associated with perceived role ambiguity, which in turn associated with lower job performance and higher absenteeism. For employees with higher organizational tenure, by contrast, MTM associated positively with their work challenge perceptions and subsequent performance outcomes, whereas MTM was unrelated to perceived role ambiguity as well as absenteeism. These findings identify relevant psychological mechanisms and a key contingency factor that explain when and why MTM may have positive or negative individual‐level consequences.
Cooled Radiofrequency Ablation Treatment of the Genicular Nerves in the Treatment of Osteoarthritic Knee Pain: 18‐ and 24‐Month Results
Authors: Hunter Corey , Davis Tim , Loudermilk Eric , Kapural Leonardo , DePalma Michael 
Published: October 2019

AbstractObjectiveThe primary objective of this observational, prospective, multicenter study was to evaluate the long‐term outcomes, including pain, function, and perceived effect of treatment, in subjects undergoing cooled radiofrequency ablation (CRFA) who have pain due to osteoarthritis (OA) of the knee.MethodsThis analysis included a subset of subjects previously enrolled in a prospective, multicenter randomized study comparing the safety and effectiveness of CRFA and intra‐articular steroid injection in patients with knee OA through 12 months who were contacted to participate in this extension study. Subjects were enrolled if they agreed to participate in up to 2 additional follow‐ups, at 18 and 24 months.ResultsEighty‐three subjects from the 5 participating sites underwent CRFA during the original study and were contacted for this extension study. Of the 33 subjects enrolled, 25 were evaluated at 18 months after CRFA treatment, and their mean numeric rating scale (NRS) score was 3.1 ± 2.7, with 12 subjects reporting ≥50% pain relief compared to baseline. At 24 months, 18 subjects reported a mean NRS score of 3.6 ± 2.8, with 11 demonstrating ≥50% pain relief. Functional improvement as measured by the Oxford Knee Score continued to be present, with an overall mean change from baseline of 26.0 ± 9.6 points at 18 months and 29.9 ± 10.4 points at 24 months.ConclusionIn this subset of subjects from a randomized controlled trial, CRFA provided sustained pain relief, improved function, and perceived positive effect through 24 months for subjects with OA knee pain with no safety concerns identified.
By failing to prepare, you are preparing your anterior cruciate ligament to fail
Authors: Staynor Jonathan M. D. , Alderson Jacqueline A. , Byrne Sean , Rossi Marcel , Donnelly Cyril J. 
Published: October 2019

There is strong evidence linking an athlete's movement technique during sidestepping with anterior cruciate ligament (ACL) injury risk. However, it is unclear how these injurious postures are influenced by prior movement. We aim to describe preparatory trunk and thigh kinematics at toe‐off of the penultimate‐step and flight‐phase angular momenta, and explore their associations with frontal‐plane risk factors during unplanned sidestepping maneuvers. We analyzed kinematic and kinetic data of 33 male Australian Football players performing unplanned sidestepping tasks (103 trials). Linear mixed models tested for reliable associations between ACL injury risk during weight acceptance of the execution‐step, with preparatory kinematics and angular momenta of the trunk and thigh during the penultimate‐step. Multi‐planar flight‐phase trunk momenta along with hip abduction angle at penultimate‐step toe‐off were significantly associated with peak knee valgus moments during the execution‐step (R2 = .21, P < .01). Execution‐step trunk lateral flexion was significantly predicted by frontal and sagittal‐plane preparatory trunk positioning at toe‐off of the penultimate‐step (R2 = .44, P < .01). Multi‐planar flight‐phase trunk momenta as well as multi‐planar trunk and hip positioning at penultimate‐step toe‐off were associated with hip abduction during the execution‐step (R2 = .53, P < .01). Preparatory positioning of the trunk and hip, along with flight‐phase trunk momentum adjusting this positioning are linked to known ACL injury risk factors. We recommend that during the penultimate‐step athletes maintain an upright trunk, as well as minimize frontal‐plane trunk momentum and transverse‐plane trunk momentum toward the sidestep direction to reduce risk of ACL injury during unplanned sidesteps.
Evaluation of the role of transhepatic flow in postoperative outcomes following major hepatectomy (THEFLOW): study protocol for a single-centre, non-interventional cohort study
Authors: Golriz Mohammad , Lemekhova Anastasia , Khajeh Elias , Ghamarnejad Omid , Al-Saeedi Mohammed , Strobel Oliver , Hackert Thilo , Müller-Stich Beat , Schneider Martin , Berchtold Christoph , Tinoush Parham , Mayer Philipp , Chang De-Hua , Weiss Karl Heinz , Hoffmann Katrin , Mehrabi Arianeb 
Published: October 2019

IntroductionLiver resection is the only curative treatment for primary and secondary hepatic tumours. Improvements in perioperative preparation of patients and new surgical developments have made complex liver resections possible. However, small for size and flow syndrome (SFSF) is still a challenging issue, rendering patients inoperable and causing postoperative morbidity and mortality. Although the role of transhepatic flow in the postoperative outcome has been shown in small partial liver transplantation and experimental studies of SFSF, this has never been studied in the clinical setting following liver resection. The aim of this study is to systematically evaluate transhepatic flow changes following major liver resection and its correlation with postoperative outcomes.Methods and analysisThe TransHEpatic FLOW (THEFLOW) study is a single-centre, non-interventional cohort study, and aims to enrol 50 patients undergoing major hepatectomy (defined as hemihepatectomy or extended hepatectomy based on the Brisbane classification) with or without prior chemotherapy. The portal venous flow, hepatic artery flow and portal venous pressure are measured before and after each resection. All patients are followed-up for 3 months after the operation. During each evaluation, standard clinical data, posthepatectomy liver failure and overall morbidity and mortality will be recorded. THEFLOW study was initiated on 25 March 2018 and is expected to progress for 2 years.Ethics and disseminationThis protocol study received approval from the Ethics Committee of the University of Heidelberg (registration number: S576/2017). The results of this study will be published in a peer-reviewed journal, and will also be presented at medical meetings.Trial registration numberNCT03762876.
Prevalence and factors associated with frailty among community-dwelling older people in rural Thanjavur district of South India: a cross-sectional study
Authors: Kendhapedi Kirubakaran Kesavan , Devasenapathy Niveditha 
Published: October 2019

ObjectiveThere is sparse data on the prevalence of frailty from rural parts of India. Our aim was to estimate prevalence of frailty among community-dwelling older people in rural South Indian population and explore socio-demographic factors associated with frailty. We further explored the associations between frailty with fear of falling and falls.DesignCommunity based cross-sectional study.SettingFour villages in Thanjavur district of Southern India.ParticipantsRandom sample of adults aged 60 years and above from four villages.MethodsWe sampled community-dwelling older adults from the electoral list of four villages using stratified random sampling. We report prevalence of frailty as defined by physical definition (Fried’s Phenotype), accumulation of deficits (Frailty Index) and multi-domain definition (Tilburg Frailty Indicator). We report proportion of agreement of frailty status between the frailty tools. We used logistic regressions with robust SEs to examine the associations between socio-demographic determinants with frailty and the association between frailty with fear of falling and falls.ResultsAmong the 408 participants, the weighted (non-response and poststratification for sex) prevalence and 95% CI of frailty was 28% (18.9 to 28.1) for physical definition, 59% (53.9 to 64.3) for accumulation of deficits and 63% (57.4 to 67.6) for multi-domain definition. Frailty Index and Tilburg Frailty Indicator had good agreement (80%). Age, female, lower education, lower socioeconomic status, minimum physical activity in routine work were independently associated with frailty irrespective of the frailty definitions. Frail elderly had higher odds of falls as well as fear of falling compared with non-frail, irrespective of the definitions.ConclusionPrevalence of frailty among older people in rural Thanjavur district of South India was high compared with low-income and middle-income countries. Understanding the modifiable determinants of frailty can provide a valuable reference for future prevention and intervention.
Complete trajectory reconstruction from sparse mobile phone data
Authors: Chen Guangshuo , Viana Aline Carneiro , Fiore Marco , Sarraute Carlos 
Published: October 2019

Abstract
Mobile phone data are a popular source of positioning information in many recent studies that have largely improved our understanding of human mobility. These data consist of time-stamped and geo-referenced communication events recorded by network operators, on a per-subscriber basis. They allow for unprecedented tracking of populations of millions of individuals over long periods that span months. Nevertheless, due to the uneven processes that govern mobile communications, the sampling of user locations provided by mobile phone data tends to be sparse and irregular in time, leading to substantial gaps in the resulting trajectory information. In this paper, we illustrate the severity of the problem through an empirical study of a large-scale Call Detail Records (CDR) dataset. We then propose Context-enhanced Trajectory Reconstruction, a new technique that hinges on tensor factorization as a core method to complete individual CDR-based trajectories. The proposed solution infers missing locations with a median displacement within two network cells from the actual position of the user, on an hourly basis and even when as little as 1% of her original mobility is known. Our approach lets us revisit seminal works in the light of complete mobility data, unveiling potential biases that incomplete trajectories obtained from legacy CDR induce on key results about human mobility laws, trajectory uniqueness, and movement predictability.
Testicular melanization in anuran species: ontogeny and sexual maturity
Authors: Goldberg Javier , Valverde Bruno S.L. , Franco-Belussi Lilian 
Published: October 2019

Abstract
Testicular melanization in anurans may be absent or present with different degrees of intensity. When present, the color is due to the concentration of melanocytes in external (surface) and interstitial tissue. The function of this coloration is not fully known and we ask if melanization during testicular development, in species with highly pigmented testes in adults, is correlated with germ cells maturation. To do so, we selected four anuran species with highly pigmented testes. Species differed in the amount of interstitial melanin. Pigmentation increased throughout ontogeny, but with interspecific variation in the onset and rate. The rate of melanization progressed with testicular differentiation. A threshold for interstitial pigmentation seems to be reached with the advancement of spermatogenesis. Overall, testicular pigmentation adds a new chapter to the study of sexual maturity in anurans.
Pathogenicity of the root-lesion nematode, Pratylenchus zeae, on rice genotypes under different hydro-ecologies in Tanzania
Authors: Nzogela Yasinta Beda , Landschoot Sofie , Kihupi Ashura-Luzi , Coyne Danny L. , Gheysen Godelieve 
Published: October 2019

Summary
The root-lesion nematode, Pratylenchus zeae, is commonly found in upland rice fields. To measure the impact of the nematode on rice production, a screenhouse experiment was conducted using two farmer-adapted Oryza sativa cultivars, ‘Supa’ (‘SurinamV-880’) and ‘SARO-5’ (‘TXD 306’), under flooded, upland and drought water regimes imposed at 7 days post-inoculation of mixed-stage nematodes (200, 500, 1000, 3000 and 10 000 plant−1). Growth and yield parameters were recorded, and the experiment was terminated after 5 months. ‘Supa’ was shown to be resistant to P. zeae, while ‘SARO-5’ was susceptible. Pratylenchus zeae reduced the growth and yield of both cultivars, though more for ‘SARO-5’ than for ‘Supa’. Yield decreased with increasing final nematode densities. Pratylenchus zeae reproduction was highest at 200 and 500 inoculum levels and under upland water conditions. The yield of ‘SARO-5’ was greater than that of ‘Supa’ under flooded conditions and with no or 200 and 500 nematode inoculum levels, but with high P. zeae inoculum ‘Supa’ yield was better than ‘SARO-5’.
The Construction of a Philosophical Textbook: Some Remarks on Nikephoros Blemmydes’ Epitome physica
Authors: Valente Stefano 
Published: October 2019

Abstract
The Compendium on Physics (Epitome physica) by the Byzantine theologian and philosopher Nikephoros Blemmydes (13th cent.) was a very successful textbook on Natural Philosophy containing a summary of physics, meteorology and astronomy. This compendium was also conceived for being used as support for teaching. For his purposes, Blemmydes combined passages taken from different sources into a new text: Aristotle and his commentators as well as Cleomedes were his main sources. Since a manuscript with an earlier version of the text still survives, it is also possible to go deeper into the workshop of this Byzantine author and to investigate the use of the sources in both textual stages. This paper will therefore be devoted to analysing the inner structure of the Epitome physica and Blemmydes’ activity as an author.
La metodologia del Commento nei trattati sull’interpretatio iuris di età umanistica
Authors: Luongo Dario 
Published: October 2019

Abstract
In this paper we examine some treatises about interpretatio iuris that encode the methodology of the Italian ‘scuola del commento’, from the end of the Middle Ages onwards. Those writings reaffirm the primacy of the mens or sensus over the verba of the law. In all these treatises, the law is considered the expression of ratio rather than of the voluntas principis: therefore, its efficacy must be addressed by means of specific and different jurisprudential work. We illustrate this methodology through a detailed analysis of the treatises by C. Rogerio, B. Cepolla, S. Federici, P. A. Gammaro.
Natural History of Renal Vein Thrombosis: Incidence of Recurrent Venous Thromboembolism and Survival.
Authors: Wysokinski Waldemar E. , Gosk-Bierska Izabela , Karnicki Krzysztof , Pruthi Rajiv K. , McBane Robert D. 
Published: October 2019

Abstract
Renal vein thrombosis (RVT), although uncommon, is associated with considerable morbidity and mortality. Neither the etiology nor the natural history of RVT has been adequately described in a large case series.
Objective: To determine whether incident RVT is associated with an increased likelihood of recurrent local and systemic venous thromboembolic disease.
Methods: Cases were identified by reviewing the Diagnostic Index for all patients with RVT at our institution between 1981 and 2000.
Results: The study group consisted of 240 patients (34% women) with a mean age 55± 19 years. The diagnosis of RVT was made by CT (35%), Duplex Ultrasound (35%), MRI±gadolinium (10%) and either at surgery or autopsy in the remainder. The underlying etiology was deemed to be malignancy in 65% of cases. Of these, renal cell carcinoma (74%) and Wilms tumor (3%) made up the majority. Nephrotic syndrome primarily membranous glomerulonephritis was the second most common underlying etiology (23%). Of those tested, a definable thrombophilia was found in only 13 cases including lupus anticoagulant/antiphospholipid antibody (n=4); deficiencies of protein C or S, (n=2 each); heparin induced thrombocytopenia (n=2); antithrombin deficiency, dysfibrinogenemia and hyperhomocysteinemia (n=1 each). Eighty-one patients (34%) were treated with warfarin. Over a mean follow up of 3 years, the rate of recurrence of venous thrombosis at any site was 5%. The mortality rate over this time period was 49%.
Conclusion: RVT represents a distinct clinical entity relative to venous thromboembolism of the lower extremity. The observed low rate of recurrence may be explained by the high mortality rate owing to a high percentage of renal malignancy. RVT should prompt an evaluation for an underlying renal malignancy.
Protein Profiling in Childhood Precursor B Acute Lymphoblastic Leukemia using Surface Enhanced Laser Desorption/Ionization (SELDI) Mass Spectrometry: A Study of Archival Samples.
Authors: Czader Magdalena , Dobrolecki Lacey , Ragg Suzanne , Orazi Attilio , Hickey Robert 
Published: October 2019

Abstract
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Even though the risk-group adjusted therapies have dramatically improved the outcome, approximately 25% of ALL patients experience relapse of the disease. Recent gene microarray studies showed distinct gene expression profiles for immunophenotypically and genetically defined ALL subgroups and their association with treatment outcome. However, not only transcriptional control, but also a variety of post-transcriptional/post-translational modifications, play an important role in regulating protein expression and function, and ultimately may prove informative for predicting tumor behavior. In this pilot study, we hypothesize that in childhood precursor B ALL surface enhanced laser desorption/ionization mass spectrometry can identify proteins discriminating between age and WBC defined risk-groups. Ultimately, specific proteins may emerge that will provide predictive information beyond currently known prognostic factors. Our pilot series consisted of 78 pediatric precursor B ALL patients. The protein samples were obtained from archival Wright-Giemsa stained bone marrow aspirate smears. Initial experiments, using CM10 and IMAC30 chips demonstrated that the latter provided superior resolution and presented more numerous protein peaks. The protein mass spectra were originally generated using laser intensities of 150 and 160 arbitrary units. Data obtained at laser intensity of 160 was used for further analysis. Twenty-three protein peaks common to all samples were identified within examined range (up to 30 kDa; CiphergenExpressData Manager software, Ciphergen, Fremont, CA). These proteins span the spectrum between 1.0 to 15.2 kDa. The comparison of protein profiles between standard- and high-risk groups (SR and HR, respectively), WBC subgroups (less and more than 50 K/ul) and in the prognostic age groups was performed. Two protein peaks, 3.0 and 1.7 kDa, discriminated between SR and HR (p=0.001 and p=0.04, respectively). Both proteins showed significantly higher intensity in SR group. The protein peak of 3.0 kDa was further confirmed to discriminate between patients with low and high presentation WBC (p=0.01). Our results demonstrate that reliable quality protein profiles can be obtained using archival Wright-Giemsa stained bone marrow aspirate smears. Using this technology, specific proteins were found to discriminate between prognostic risk-groups. We are currently analyzing precursor B-cells sorted from non-neoplastic bone marrows to compare protein profiles to our pilot precursor B ALL series in a cluster analysis. The use of archival material facilitates analysis of large patient series and identification of protein panels with prognostic power, which can be validated in prospective studies.
Microrna Expression Profiling in Acute Myelogenous Leukemia.
Authors: Suarez Saiz Fernando J. , San-Marina Serban , Minden Mark D. 
Published: October 2019

Abstract
Acute myelogenous leukemia (AML) arises due to changes in gene expression that block or alter the normal differentiation program of hematopoietic stem cells. A variety of mutations in protein-encoding genes have been shown to contribute to the development of leukemia. Recently a new class of genes called microRNAs (miRNAs) have been identified. miRNAs are a subgroup of highly conserved, non-coding RNAs found only in eukaryotes. They do not encode proteins, and appear to have a significant effect on the proteome of a cell. Their conservation between species suggests their involvement in important biological functions, and in fact been shown to be involved in hematopoietic differentiation. While the function of most miRNAs is still unknown, it is believed that they regulate expression of target mRNAs by using the siRNA machinery either to promote degradation of the mRNA or to block its translation. To begin to understand the role of miRNAs in AML, we used Quantitative Polymerase Chain Reaction (QPCR) to measure the expression level of 20 miRNA precursors in the pro erythroid cell line K562, the pro-myelocytic cell line NB4, the myelomococytic cell line OCI/AML2, AML patients’ blasts and in normal bone marrow (NBM). The investigated miRNAs included some that are known to be specific for hematopoietic tissues or involved in hematopoietic differentiation, as well as all the miRNAs in chromosome 7, a hot spot for gene deletion in AML. Our findings indicate that miRNAs are differentially expressed in patients and cell lines when compared among themselves and against normal bone marrow. For example pre-miR-142 was expressed in NBM and K562 but was found to be elevated in OCI/AML2, NB4 and in all patient samples. Pre-miR-20 was found to be overexpressed in only a subset of patients. Other miRNAs like pre-miR-335 and pre-miR-148a were expressed in NBM and in some patients and not in the cell lines. In an effort to identify possible regulators of miRNA expression, we analyzed the upstream region of pre-miR-142 and found an LMO2 binding site. In AML, the LMO2 gene can be overexpressed relative to normal bone marrow and healthy lymphocytes. This transcription factor is involved in the regulation of genes important in the development of blood cells. To investigate if LMO2 could be involved in the regulation of miR-142 expression, we performed chromatin immunoprecipitation (ChIP) from K562 using an anti-LMO2 antibody. Only the LMO2 immunoprecipitation, and not those from the pre-immune control, were enriched in promoter DNA for pre-miR-142. This is consistent with the observation that miRNAs and coding RNAs can be regulated by the same environmental signals. Based on this observation we propose that oncogenes regulate in part the phenotype and biological behaviour of leukemia by affecting the expression of miRNAs. This further suggests that different forms of leukemia may be recognized based upon the spectrum of miRNAs they express.