bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triiodothyronine levels and mortality in children with sepsis and septic shock
Authors: Destariani Cynthea Prima , Lubis Munar , Deliana Melda , Yanni Gema Nazri 
Published: March 2018

Background Sepsis is the most common cause of death in infants and children. It can cause hormonal imbalances, such as euthyroid sick syndrome (ESS), which may increase the risk of death.Objective To evaluate a possible correlation between the level of triiodothyronine (T3) and mortality in children with sepsis and septic shock.Methods An observational cohort study was conducted on 80 children with sepsis and septic shock from October 2015 until January 2016 in Haji Adam Malik General Hospital, Medan. Subjects underwent PELOD score and T3 examination on the first day admitted in Haji Adam Malik General Hospital. Chi-square test was used to analyze for a correlation between the T3 values and mortality. Results Of the 80 consecutive subjects, 39 (48.75%) had low T3 level on the first day. Of these 39 children, 36 (92.3%) died. Subjects with low T3 level had a 6.31 times higher risk of mortality(PR 6.31; 95%CI 2.99 to 13.28; P<0.001). Of the 31 subjects with high PELOD score, 23 (74.2%) had decreased T3 (PR=2.27; 95%CI 1.45 to 3.57; P<0.001).Conclusion Low T3 level has significant relationship with mortality in children with sepsis and septic shock.
Effects of fixture rotation on coating uniformity for high-performance optical filter fabrication
Authors: Rubin Binyamin , George Jason , Singhal Riju 
Published: March 2018

Abstract
Coating uniformity is critical in fabricating high-performance optical filters by various vacuum deposition methods. Simple and planetary rotation systems with shadow masks are used to achieve the required uniformity [J. B. Oliver and D. Talbot, Appl. Optics 45, 13, 3097 (2006); O. Lyngnes, K. Kraus, A. Ode and T. Erguder, in ‘Method for Designing Coating Thickness Uniformity Shadow Masks for Deposition Systems with a Planetary Fixture’, 2014 Technical Conference Proceedings, Optical Coatings, August 13, 2014, DOI: http://dx.doi.org/10.14332/svc14.proc.1817.]. In this work, we discuss the effect of rotation pattern and speed on thickness uniformity in an ion beam sputter deposition system. Numerical modeling is used to determine statistical distribution of random thickness errors in coating layers. The relationship between thickness tolerance and production yield are simulated theoretically and demonstrated experimentally. Production yields for different optical filters produced in an ion beam deposition system with planetary rotation are presented. Single-wavelength and broadband optical monitoring systems were used for endpoint monitoring during filter deposition. Limitations of thickness tolerances that can be achieved in systems with planetary rotation are shown. Paths for improving production yield in an ion beam deposition system are described.
On the formula of Cohen–Vogt relatively pointed topological semi-simplicial sets
Authors: Mdzinarishvili Leonard 
Published: March 2018

Abstract
In the papers [1] and [6], for an inverse sequence of pointed topological spaces and fibrations preserving the base points

E
=

E
1

←

p
1

E
2

←

p
2

⋯

←

p
m

E

m
+
1

,

E=E_{1}\xleftarrow{p_{1}}E_{2}\xleftarrow{p_{2}}\cdots\xleftarrow{p_{m}}E_{m+1},

there exists an exact sequence

*
→

lim
←

(
1
)

[
X
,
Ω

E
m

]

→

[
X
,

lim
←

E
]

→

lim
←

(
1
)

[
X
,

E
m

]

→
*
.

*\rightarrow{\varprojlim}^{(1)}[X,\Omega E_{m}]\rightarrow[X,\varprojlim E]%
\rightarrow{\varprojlim}^{(1)}[X,E_{m}]\rightarrow*.

In the present paper, for an inverse sequence of pointed topological semi-simplicial sets and fibrations preserving base points

E
¯

=

E
¯

←

p
1

1

E
¯

←

p
2

2

⋯

←

p
m

E
¯

←

m
+
1

⋯
,

\underline{E}=\underline{E}{}_{1}\xleftarrow{p_{1}}\underline{E}{}_{2}%
\xleftarrow{p_{2}}\cdots\xleftarrow{p_{m}}\underline{E}{}_{m+1}\xleftarrow{%
\hphantom{p_{1}}}\cdots,

an analogous formula is proved.
CD45RO regulates the HIV-1 gp120-mediated apoptosis of T cells by activating Lck
Authors: Li Kelei , Cong Zhe , Peng Zhuoying , Chen Ting , Xue Jing , Wei Qiang 
Published: March 2018

AbstractCD45 has been reported to regulate the HIV-1 gp120-induced apoptosis of Jurkat cells. Here, we demonstrate that the extracellular domain of CD45 plays an important role in this function. We observed that CD45RO-transfected cells, but not cells transfected with other CD45 isoforms, underwent significant apoptosis induced by gp120. However, a CD45RA-transfected cell line treated with anO-glycan inhibitor was able to undergo apoptosis. The role of the extracellular domain of CD45 was further confirmed using CD45 isoform-transfected cell lines by analyzing the phosphorylation of Lck, which is a direct substrate of CD45 tyrosine phosphatase, and by using an Lck inhibitor. These results suggest that CD45RO modulates HIV-1 gp120-induced apoptosis by regulating the activity of Lck.
Increase in an Intracellular β-Galactosidase Biosynthesis Using L. reuteri NRRL B-14171, Inducers and Alternative Low-Cost Nitrogen Sources under Submerged Cultivation
Authors: Gomes Tatiane A. , Santos Luiza B. , Nogueira Alessandro , Spier Michele R. 
Published: March 2018

Abstract
The aim of this study was to select among lactic acid bacteria (LAB) and yeast a potential β-galactosidase producer, based on bioprocess parameters. From the selected microorganism,  different organic cheaper nitrogen sources (single and combined) with low cost for β-galactosidase production were evaluated. Lactobacillus reuteri B-14171 showed the highest enzymatic activity (1,286 U L−1), high productivity (28.78 U L h−1) and yield factor (82.32 U g−1), evidencing its potential for β-galactosidase production. All organic nitrogen sources tested were viable for the enzymatic production using L. reuteri B-14171. The MMRS casein (3.0 g L−1) + inactive beer yeast (3.0 g L−1) as nitrogen source increased the enzymatic activity (1269 U L−1) with 1.83 times lower production costs of culture medium when compared to MMRS-yeast extract B. The MMRS casein + inactive beer yeast has proved to be an innovative and cheaper nitrogen source for β-galactosidase production by L. reuteri B-14171.
Global Mittag–Leffler Synchronization for Impulsive Fractional-Order Neural Networks with Delays
Authors: Rifhat Ramziya , Muhammadhaji Ahmadjan , Teng Zhidong 
Published: March 2018

Abstract
In this paper, we investigate the synchronization problem of impulsive fractional-order neural networks with both time-varying and distributed delays. By using the fractional Lyapunov method and Mittag–Leffler function, some sufficient conditions are derived to realize the global Mittag–Leffler synchronization of impulsive fractional-order neural networks and one illustrative example is given to demonstrate the effectiveness of the obtained results.
Understanding the direct involvement of parents in policy development and school activities in a primary school
Authors: Tobin Bernie 
Published: March 2018

AbstractIt is acknowledged that parental engagement with children’s learning and education is of vital importance. But, there is a tendency to confuse engagement with learning with engagement with the school. While all types of parents’ involvement can have a positive effect, it is actually what parents do with their child at home that has the greatest impact. However, unless parental involvement in learning is embedded in whole-school processes it is unlikely to as effective as possible. This paper documents an action research study that explores the inclusion of parents and home values in the construction of the teaching and learning environment. This was a small step towards positive parent-teacher collaboration, which allowed an exchange of knowledge, values and cultural background experiences. In acknowledging the ways in which the parents already engaged with their children’s learning, it began to enhance self-efficacy in their ability to directly affect this learning. This work has also provoked reflexive engagement of my influence and understanding of involving parents of children with additional and diverse learning needs. But, it also details the transformative journey that influenced my thinking about how we as a school could begin to develop whole-school processes to directly involve parents in policy development and school activities.
Mapping tense form and meaning for L2 learning – From theory to practice
Authors: Svalberg Agneta Marie-Louise 
Published: March 2018

AbstractEnglish tense presents second/foreign language learners with considerable cognitive challenges and, it will be argued, grammars and textbooks are generally inadequate sources of knowledge of the tense system as system. A modified version of Reichenbach's (1947.Elements of Symbolic Logic. New York: Macmillan) tense model is then presented. The original model has been criticized for its inability to deal with temporal relationships in natural text (e. g. Declerck, R. 1986. From Reichenbach (1947) to Comrie (1985) and beyond. Towards a theory of tense.Lingua70. 305–364; Declerck, R. 2015.Tense in English. Its structure and use in discourse. London: Routledge; Carroll, M., C. Von Stutterheim & W. Klein. 2003. Two ways of construing complex temporal structures. In F. Lenz (ed.),Deictic Conceptualisation of Time, Space and Person, 97–134. Amsterdam: Benjamins). It is argued here instead that speakers employ the limited choices the system provides creatively, to express a wide range of temporal and interpersonal relations in the real world. The tense - aspect and tense - modality interfaces are briefly discussed. A pedagogical Language Awareness approach (Svalberg, A. M-L. 2007. Language Awareness and Language Learning.Language Teaching40(4). 287–308) is then illustrated, with the theoretical model as mediating artefact providing visual and metalinguistic scaffolding, allowing learners to investigate tense use in context while drawing on both intuitive understanding and conscious knowledge.
Directionality and complexity of L1 transfer in L2 acquisition: Evidence from L2 Chinese discourse
Authors: Yuan Boping , Lin Yvonne 
Published: March 2018

Abstract
First language (L1) transfer is a common phenomenon in second language (L2) acquisition. However, it will be argued in this article that although there are indeed pervasive influences of learners’ L1 in L2 acquisition, L1 transfer is not everywhere and it can be directional. We compare data from Chang’s (2001b. Discourse effects on the second language acquisition of English and Chinese dative structures. Honolulu: University of Hawai’i at Manoa PhD dissertation, 2004. Discourse effects on EFL learners’ production of dative constructions. Journal of Kaohsiung University of Applied Sciences 33. 145–169.) studies of Chinese-speaking learners of English with data of our study of English-speaking learners of Chinese to examine whether their L2 English discourse and L2 Chinese discourse are equally influenced by their L1 discourse rules. We focus on learners’ answers to wh-questions with a double object construction or a prepositional object construction. The results demonstrate that L1 transfer takes place in Chinese-speaking learners’ L2 English discourse but not in English-speaking learners’ L2 Chinese discourse. This directionality of L1 transfer is accounted for on the basis of computational complexity of linguistic structures involved and on an economical consideration.
Recent developments in cell-based ENS regeneration – a short review
Authors: Obermayr Florian , Seitz Guido 
Published: March 2018

AbstractTherapeutic options to treat neurogenic motility disorders of the gastrointestinal tract are usually limited to symptomatic treatment. The capacity of the enteric nervous system (ENS) to regenerate and the fact that progenitor cells of the enteric nervous system reside in the postnatal and adult gut led to the idea to develop cell-based strategies to treat ENS related disorders. This short review focuses on recent developments in cell-based ENS regeneration, discussing advantages and disadvantages of various cell sources, functional impact of transplanted cells and highlights the challenges of translation of small animal studies to human application.
Will Total Knee Replacement Ever Provide Normal Knee Function?
Authors: Gergely István , Pop Tudor Sorin , Bățagă Tiberiu , Feier Andrei-Marian , Zuh Sándor-György , Russu Octav 
Published: March 2018

Abstract
Knee osteoarthritis or gonarthrosis is considered the most common joint disease, affecting more than 70% of subjects aged over 65 years. Its occurrence is increasing with age and is more problematic with the current rise in the incidence of obesity. In severe and advanced cases, total knee arthroplasty is recommended as a gold standard therapy for pain relief, restoration of normal knee function, and quality of life improvement. There are numerous controversies whether total knee arthroplasty is able to reach and provide end-point outcomes and restore previous function of the knee joint. Studies suggest that the surgeons’ experience, type of prosthesis used, associated pathology, underlying pathologies, risk factors, continuous passive movement, and patient expectations about the surgery may influence the outcomes to a great extent. “Normal knee function” is a statement that is hardly defined in the current literature, as authors usually refer to subjective results when analyzing outcomes. Objective results may be more straightforward, but they do not always symbolize the actual state that the patient is reporting or the actual quality of life. Our objective was to analyze and present summaries of the current literature regarding normal knee function restoration after total knee replacement surgery. Our literature review results confirm the hypothesis that subjective and objective results are difficult to interpret and unravel. Complex future trials may bring supplementary and clearer conclusions regarding knee function and kinematics, clinical improvement, patient satisfaction, and quality of life.
Imaging-derived Biomarkers Associated with Atrial FIBROsis, Structural Remodeling and the Risk of Cardioembolic Events in Patients with Atrial Fibrillation – the FIBROS Study
Authors: Oltean-Péter Balázs , Korodi Szilamér , Benedek István , Lázár Erzsébet , Kéri Johanna , Pakucs Annamária , Kovács István , Bordi Lehel , Mitre Adriana , Benedek Imre , Benedek Theodora , Benedek István 
Published: March 2018

Abstract
Recent studies demonstrated that despite restoration of the sinus rhythm, patients with a positive history of atrial fibrillation (AF) are still at risk of thromboembolic events. The primary objective of this study is to identify new imaging-derived biomarkers provided by modern imaging technologies, such as cardiac computed tomography angiography, delayed enhancement magnetic resonance imaging, or speckle tracking echocardiography, as well as hematological biomarkers, associated with the risk of intracavitary thrombosis in patients with AF, in order to identify the imaging-derived characteristics associated with an increased risk of cardioembolic events. Imaging data collected will be post-processed using advanced techniques of computational modeling, in order to fully characterize the degree of structural remodeling and the amount of atrial fibrosis. The primary endpoint of the study is represented by the rate of thromboembolic events. The rate of cardiovascular death, the rate of major adverse cardiovascular events, and the rate of AF recurrence will also be determined in relation to the degree of structural remodeling and atrial fibrosis.
Foreign Relations of Post-Independence Montenegro: A Change of Direction
Authors: Vukicevic Boris 
Published: March 2018

Abstract
Montenegro, the smallest country in the Balkans, had led a long struggle for independence against various empires. Because of Montenegrin Orthodox Christian and Slavic heritage, Russia was historically its main patron. However, after regaining independence in 2006, Montenegro set amongst its top priorities the membership in the European Union and NATO, whilst trying to pursue good relations with other actors in the region. This paper deals with the adaptability of a small country to changes of regional and global context whilst comparing its relations with its former and contemporary allies. It also deals with a set of its foreign and security policy priorities and how they are fulfilled.
Generalized state maps and states on pseudo equality algebras
Authors: Cheng Xiao Yun , Xin Xiao Long , He Peng Fei 
Published: March 2018

Abstract
In this paper, we attempt to cope with states in a universal algebraic setting, that is, introduce a notion of generalized state map from a pseudo equality algebra X to an arbitrary pseudo equality algebra Y. We give two types of special generalized state maps, namely, generalized states and generalized internal states. Also, we study two types of states, namely, Bosbach states and Riečan states. Finally, we discuss the relations among generalized state maps, states and internal states (or state operators) on pseudo equality algebras. We verify the results that generalized internal states are the generalization of internal states, and generalized states are the generalization of state-morphisms on pseudo equality algebras. Furthermore, we obtain that generalized states are the generalization of Bosbach states and Riečan states on linearly ordered and involutive pseudo equality algebras, respectively. Hence we can come to the conclusion that, in a sense, generalized state maps can be viewed as a possible united framework of the states and the internal states, the state-morphisms and the internal state-morphisms on pseudo equality algebras.
Monotone subsequence via ultrapower
Authors: Błaszczyk Piotr , Kanovei Vladimir , Katz Mikhail G. , Nowik Tahl 
Published: March 2018

Abstract
An ultraproduct can be a helpful organizing principle in presenting solutions of problems at many levels, as argued by Terence Tao. We apply it here to the solution of a calculus problem: every infinite sequence has a monotone infinite subsequence, and give other applications.
Evaluation of a neurokinin-1 antagonist in preventing multiple-day cisplatin-induced nausea and vomiting
Authors: Li Quanfu , Wang Wenjuan , Chen Gang , Deng Shuqin , Jiang Caihong , Chen Feng , Zhao Jun , Li Hui , Bai Xiaojun , Hu Yuliang , Da Lenggaowa , Wu Yungaowa , Jin Gaowa 
Published: March 2018

Abstract

Objective
To perform a prospective non-randomized comparison of the effectiveness and safety of combined neurokinin-1 antagonist aprepitant treatment with the standard multiple-day cisplatin regimen for the prevention of cisplatin-induced nausea and vomiting (CINV).

Methods
Patients being administered 3-day cisplatin-based chemotherapy (25 mg/m2/d) who had never received aprepitant were given either the standard regimen (tropisetron and dexamethasone) or the aprepitant regimen (aprepitant plus tropisetron and dexamethasone). The primary endpoint was the complete response (CR) in the overall phase (OP, 0–120 h) between the combined aprepitant triple regimen group and the standard group. Secondary endpoints were the CR in the acute phase (AP, 0–24 h) and delay phase (DP, 25–120 h) between the two groups. The first time of vomiting was also compared by Kaplan–Meier curves. The impact of CINV on the quality of life was assessed by the Functional Living Index-Emesis (FLIE). Aprepitant-related adverse effects (AEs) were also recorded.

Results
A CR was achieved by 80.0% in the aprepitant group compared with 56.0% in the standard group during the OP (P =0.018)as well as during the DP. However, during the AP, the aprepitant and standard therapy groups achieved identical CR rates (98.0%, P =1.000). A longer time to first emesis was documented for the aprepitant group than for the standard group. No effect of CINV on quality of life as assessed by FLIE was reported by 44.7% of aprepitant therapy patients and 24.0% of standard therapy patients (P=0.035). The main aprepitant-related AEs were fatigue and constipation, but there was no significant difference between groups.

Conclusion
Combined aprepitant therapy is recommended for the prevention of multiple-day CINV because of its improved CINV control rate and safety.
Value of continuous video EEG and EEG responses to thermesthesia stimulation in prognosis evaluation of comatose patients after cardiopulmonary resuscitation
Authors: Jianmin Qiu , Xueliang You , Liqin Liu , Yongsheng Wu , Licang He , Yuanxin Huang 
Published: March 2018

Abstract

Objective
To investigate the clinical value of video-electroencephalography (VEEG) and thermal stimulus on evaluating the prognosis of comatose patients after cardiopulmonary resuscitation.

Methods
Twenty eight comatose patients with cardiopulmonary resuscitation were included in the department of ICU of the First Teaching Hospital of Fujian Medical University from February 2013 to March 2016. Of the included 28 patients, 20 cases died (death group) and 8 cases survived (survival group) after cardiopulmonary resuscitation. The VEEG, Glasgow Coma Scale (GCS) and APACHE II score were recorded and compared between the death and survival group. The prediction value of death for VEEG, GCS and APACHE II were evaluated through sensitivity, specificity and area under the receiver operating characteristic (ROC) curve (AUC).

Results
GCS and APACHEH II score were statistical different between the death and survival group (P<0.05). With the increase of VEEG grading, the mortality rate of patients increased significantly (P<0.05). Predicting value of mortality for GCS, VEEG and APACHEH II were 57.69%, 61.54% and 71.43% respectively without statistical difference (P>0.05). The death prediction sensitivity and specificity for GCS were 67.0% and 85.0%, for APACHEH II were 95.1% and 85.0%, for VEEG were 100.0% and 85.2%. VEEG has the highest sensitivity, Specificity, coincidence rate and Kappa vale compared to GCS, and APACHEH II.

Conclusion
Video-electroencephalography is a useful tool for predicting the death risk for patients who received cardiopulmonary resuscitation.
Chemically vapor deposited diamond films as dosimetric material for potential clinical applications
Authors: Kabacińska Renata , Winiecki Janusz , Przegiętka Krzysztof , Szybowicz Mirosław , Fabisiak Kazimierz , Paprocki Kazimierz 
Published: March 2018

Abstract
Thermally stimulated luminescence (TL), cathodoluminescence (CL) and Raman spectroscopy of CVD diamond films grown on silicon substrates have been studied in order to obtain information on defects created during the growth, which induce the levels within the gap. TL between 300 K and 700 K, and CL from 200 nm to 1200 nm have been teasured. The glow curves show a peak located around 610 K with different intensities, depending on the sample thickness, associated with a trap of energy, equal to 0.83 eV and with attempt-to-escape-time of the order of 108 s-1. Broad CL bands observed at 428±1 nm (2.90 ±0.01 eV) and 500±1 nm (2.47±0.004 eV) are attributed to closely spaced and widely separated donor-acceptor (D-A) pairs, respectively. The TL and CL results were correlated with diamond quality estimated from Raman spectroscopy measurements.
Management als Qualifizierungsziel für Gesundheitsberufe
Authors: Hensen Peter 
Published: March 2018

Zusammenfassung
Der Managementbegriff im Gesundheits- und Sozialwesen umgreift mehr als Betriebswirtschaft und Ressourcenallokation in Versorgungseinrichtungen. Konstruktivistisch steht er für eine „reflexive Gestaltungspraxis“ zur Erschließung unterscheidbarer Praxisfelder, in denen die Gesundheitsberufe und die Berufsangehörigen eine aktive und verantwortliche Rolle einnehmen. Dies bedeutet, die primärfachlichen Kompetenzen um zusätzliche konzeptionelle, technische/funktionale und soziale Managementkompetenzen zu erweitern.