bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution and genetic control of the floral ground plan
Authors: Smyth David R. 
Published: June 2018

Contents

Summary
70

I.
Introduction
70

II.
What is the floral ground plan?
71

III.
Diversity and evolution of the floral ground plan
72

IV.
Genetic mechanisms
77

V.
What's next?
82

Acknowledgements
83

References
83

SummaryThe floral ground plan is a map of where and when floral organ primordia arise. New results combining the defined phylogeny of flowering plants with extensive character mapping have predicted that the angiosperm ancestor had whorls rather than spirals of floral organs in large numbers, and was bisexual. More confidently, the monocot ancestor likely had three organs in each whorl, whereas the rosid and asterid ancestor (Pentapetalae) had five, with the perianth now divided into sepals and petals. Genetic mechanisms underlying the establishment of the floral ground plan are being deduced using model species, the rosid Arabidopsis, the asterid Antirrhinum, and in grasses such as rice. In this review, evolutionary and genetic conclusions are drawn together, especially considering how known genes may control individual processes in the development and evolution of ground plans. These components include organ phyllotaxis, boundary formation, organ identity, merism (the number or organs per whorl), variation in the form of primordia, organ fusion, intercalary growth, floral symmetry, determinacy and, finally, cases where the distinction between flowers and inflorescences is blurred. It seems likely that new pathways of ground plan evolution, and new signalling mechanisms, will soon be uncovered by integrating morphological and genetic approaches.
Empathy and literary style
Authors: Mangen Anne , Begnum Anne Charlotte , Kuzmičová Anežka , Nilsson Kersti , Steenberg Mette , Støle Hildegunn 
Published: June 2018

AbstractThis article presents the design, methodology, and materials of an inter‐Nordic, empirical study of literary reading among students in teacher education, in which relations between literary style and experiential aspects of literary reading (e.g. empathy and transportation) were assessed empirically. The primary aim of the article is to introduce paradigms and measures from interdisciplinary empirical research on literary reading which is less known in a Nordic context but which is rapidly gaining momentum internationally. The participants in the study read Katherine Mansfield's short story “The Fly” (1922) in the original version versus in a manipulated version in which typical features of literariness (e.g. metaphors and similes) were removed. Combining quantitative measures of empathy, appreciation of literature, and aspects of reading engagement with qualitative methods, the aim is to probe deeper into readers’ subjective reading experience.
Crossroads or “Flyovers” novel insights into ventricular tachycardia mechanisms: The path is twisting
Authors: Maury Philippe , Rollin Anne , Waintraub Xavier , Capellino Stefano , Gandjbakhch Estelle 
Published: June 2018

AbstractDiverging channels of activation may be observed in some ventricular tachycardia (VT) using ultra‐high‐density mapping. We present here cases of such diverging activation patterns as observed from 60 consecutive VT activation maps using the Rhythmia system™ (Boston Scientific, Marlborough, MA, USA). Diverging directions of activation in the same area with “crossroads” or “flyover” pattern can be traced, implying recording of independent multilayer channels. Adaptation of current automated recording by the 3D mapping system is mandatory for better investigating this phenomenon.
Performance and validation of a simplified postoperative atrial fibrillation risk score
Authors: Chen Lizhu , Du Xin , Dong Jianzeng , Ma Chang‐Sheng 
Published: June 2018

AbstractBackgroundPostoperative atrial fibrillation (POAF) occurs in 20–40% patients who received isolated coronary artery cardiac bypass surgery (CABG). Several POAF risk prediction models have been developed, but none of them is widely adopted in practice. Our objective was to derive and validate a simple scoring system to estimate POAF risk after isolated CABG, using easily available clinical information.MethodsMedical records of 1,000 consecutive patients undergoing isolated CABG were reviewed. The data of first 700 patients were used for model derivation and data of the remaining 300 patients were used for model validation. Discrimination and calibration of the newly developed model were assessed.ResultsPOAF incidence in both the derivation and validation cohorts was 27.3%. Age ≥65, history of hypertension, heart failure, and myocardial infarction were independently associated with POAF risk. Risk scores were calculated by summing weighting points for each independent predictor. The score ≥3 was associated with high POAF incidence (41.1% in the derivation cohort and 44.3% in the validation cohort). The positive and negative POAF predictive value was 41.1% and 78.5%, respectively, in the derivation cohort, and 44.3% and 80.8%, respectively, in the validation cohort, when the cut‐point score ≥3 was used. The Hosmer–Lemeshow goodness‐of‐fit test P‐values were 0.917 and 0.894 in the derivation cohort and validation cohort, respectively.ConclusionsThis POAF risk following isolated CABG can be predicted with simple patient characteristic during the preoperative period. Patients with high risk scores (≥3) may constitute a target population for POAF prevention and prolonged postoperative surveillance.
Immune response in goats vaccinated with thiol‐binding proteins from Haemonchus contortus
Authors: Molina José Manuel , Hernández Yeray Isidoro , Martín Sergio , Ferrer Otilia , Rodríguez Francisco , Ruiz Antonio 
Published: June 2018

SummaryThe experimental protocol of immunization tested here confirms its protective effect against Haemonchus contortus in goats. This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (FECs). These parasitological findings were consistent with the levels of some biopathological parameters. Thus, the reduction in adult worms and FEC observed in immunized animals were associated with increased levels of packed cell volume as well as plasma proteins. This response seems to be related to an important increase in specific antibodies (in serum and gastric mucus) and eosinophilia in response to challenge. At the local level, a cellular response was also observed in which CD4+ lymphocytes and globule leucocytes played a predominant role. Finally, it should be noted that the study of immunolocalization of proteins used in the vaccination trial suggests that these antigens have an internal location (at intestinal and reproductive tissues) in the adult worm. This observation, in conjunction with the kinetics of specific antibody levels after the challenge, suggests that these antigens may be part of excretory/secretory (E/S) products.
Bayesian Log-Gaussian Cox Process Regression: Applications to Meta-Analysis of Neuroimaging Working Memory Studies
Authors: Samartsidis Pantelis , Eickhoff Claudia R. , Eickhoff Simon B. , Wager Tor D. , Barrett Lisa Feldman , Atzil Shir , Johnson Timothy D. , Nichols Thomas E. 
Published: June 2018

SummaryWorking memory (WM) was one of the first cognitive processes studied with functional magnetic resonance imaging. With now over 20 years of studies on WM, each study with tiny sample sizes, there is a need for meta-analysis to identify the brain regions that are consistently activated by WM tasks, and to understand the interstudy variation in those activations. However, current methods in the field cannot fully account for the spatial nature of neuroimaging meta-analysis data or the heterogeneity observed among WM studies. In this work, we propose a fully Bayesian random-effects metaregression model based on log-Gaussian Cox processes, which can be used for meta-analysis of neuroimaging studies. An efficient Markov chain Monte Carlo scheme for posterior simulations is presented which makes use of some recent advances in parallel computing using graphics processing units. Application of the proposed model to a real data set provides valuable insights regarding the function of the WM.
Risk acceptance of human T‐lymphotropic virus infection in solid organ transplantation—A survey of Atlantic Canadian ambulatory patients
Authors: Patriquin Glenn , Hatchette Jill E. , Hatchette Todd F. 
Published: June 2018

AbstractBackgroundHuman T‐lymphotropic virus (HTLV) has an estimated prevalence of 12 per 100 000 in the general Canadian population (with higher rates in distinct groups) and is most commonly transmitted by breast feeding, sexual intercourse, sharing injection tools, and blood transfusions. A minority of those infected will develop severe disease. Health Canada mandates that people who are positive for HTLV are not suitable to be solid organ donors. Given the apparent low‐disease burden of HTLV in Canada, we explored HTLV risk tolerance among patients, in the context of organ transplantations.MethodsUsing telephone, and in‐person questionnaires, we assessed willingness of patients to accept the risk of HTLV infection in hypothetical scenarios in which they required an organ transplant for survival.ResultsSeventy‐four outpatients attending various medical clinics participated in the survey. In a standard gamble scenario, 37.5% of respondents would have accepted a solid organ transplant regardless of HTLV risk, as compared to 27.3% and 24.6% accepting organ transplantation if there was a risk of human immunodeficiency virus (HIV) or of human virus Y (HVY; a fictitious virus describing HTLV in terms of neurological outcomes), respectively. Similarly, the median longevity traded to ensure a virus‐free organ was 4‐5 years regarding all viruses, except for HVY, for which the median time exchanged to ensure a virus‐free organ was 10 (out of a possible 20) years.ConclusionsThese data suggest that patients, though willing to accept some risk of viral infection, would not be willing to forgo HTLV screening of solid organs.
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: July 2018

Applied Economics and Finance (AEF) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 5, Number 4Ali Massoud, Sohag University, EgyptAndrey Kudryavtsev, The Max Stern Yezreel Valley Academic College, IsraelDyah Wulan Sari, Airlangga University, IndonesiaErdal Gumus, Eskisehir Osmangazi University, TurkeyEyup Kadioglu, Capital Markets Board, TurkeyGetamesay Bekele Meshesha, Debre Berhan University, EthiopiaHe Nie, Jinan University, ChinaIgor Matyushenko, School of Foreign Economic Relations and Touristic Business, UkraineJolita Vveinhardt, Lithuanian Sports University, LithuaniaMagdalena Zioło, University of Szczecin, PolandMahmoud Mohammed Sabra Al Azhar University-Gaza PalestineMamdouh Abdelmoula M. Abdelsalam, Minufiya University, EgyptMarco Muscettola, Independent Researcher-Credit Risk Manager, ItalyMarta Borda, Wroclaw University of Economics, PolandMojeed Idowu John Odumeso-Jimoh, Noble Integrated Resources & Management, NigeriaNicolas Afflatet, University of the Federal Armed Forces, GermanyNuno Crespo, ISCTE-IUL, PortugalOlena Sokolovska, Research Institute of Fiscal Policy, State Fiscal Service of Ukraine, UkrainePatrycja Kowalczyk-Rolczynska, Wroclaw University of Economics, PolandPayal Chadha, University of Wales Prifysgol Cymru, KuwaitRamona Orastean, Lucian Blaga University of Sibiu, RomaniaRichard Nguyen, Alliant International University, USARomeo Victor Ionescu, Dunarea de Jos University, RomaniaSteven V. Cates, Kaplan University, USASzabolcs Blazsek, Universidad Francisco Marroquín, GuatemalaTaro Abe, Nagoya Gakuin University, JapanVictoria Cociug, Academy of Sciences of Moldova, MoldovaZi-Yi Guo, Wells Fargo Bank, N.A., USANikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Carotid artery wall mechanics in young males with high cardiorespiratory fitness
Authors: Pugh Christopher J. A. , Stone Keeron J. , Stöhr Eric J. , McDonnell Barry J. , Thompson Jane E. S. , Talbot Jack S. , Wakeham Denis J. , Cockcroft John R. , Shave Robert 
Published: June 2018

New Findings
What is the central question of this study?
Common carotid artery (CCA) two‐dimensional strain imaging detects intrinsic arterial wall properties beyond conventional measures of arterial stiffness, but the effect of cardiorespiratory fitness on two‐dimensional strain‐derived indices of CCA stiffness is unknown.

What is the main finding and its importance?
Two‐dimensional strain imaging of the CCA revealed greater peak circumferential strain and systolic strain rate in highly fit men compared with their less fit counterparts. Altered CCA wall mechanics might reflect intrinsic training‐induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise.

AbstractThe influence of cardiorespiratory fitness on arterial stiffness in young adults remains equivocal. Beyond conventional measures of arterial stiffness, two‐dimensional strain imaging of the common carotid artery (CCA) provides new information related to the intrinsic properties of the arterial wall. Therefore, the aim of this study was to assess the effect of cardiorespiratory fitness on both conventional indices of CCA stiffness and two‐dimensional strain parameters, at rest and after a bout of aerobic exercise in young, healthy men. Short‐axis ultrasound images of the CCA were recorded in 34 healthy men {22 years old [95% confidence interval (CI), 19, 22]} before and immediately after 5 min of aerobic exercise (40% of maximal oxygen consumption). Images were analysed for arterial diameter, peak circumferential strain (PCS) and peak systolic and diastolic strain rates (S‐SR and D‐SR). Heart rate, systolic and diastolic blood pressure were simultaneously assessed, and Peterson's elastic modulus (Ep) and β‐stiffness (β1) were calculated. Participants were separated post hoc into moderate‐ and high‐fitness groups [maximal oxygen consumption, 48.9 (95% CI, 44.7, 53.2) versus 65.6 ml kg−1 min−1 (95% CI, 63.1, 68.1), respectively; P < 0.001]. The Ep and β1 were similar between groups at baseline (P > 0.13) but were elevated in the moderate‐fitness group postexercise (P < 0.04). The PCS and S‐SR were elevated in the high‐fitness group at both time points [3.0% (95% CI, 1.2, 4.9), P = 0.002, and 0.401 s−1 (95% CI, 0.085, 0.72), P = 0.02, respectively]. No group differences were observed in CCA heart rate, systolic or diastolic blood pressure or D‐SR throughout the protocol (P > 0.05). Highly fit individuals exhibit elevated CCA, PCS and S‐SR, which might reflect training‐induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise.
Quality of life of extremely preterm school-age children without major handicap: a cross-sectional observational study
Authors: Gire Catherine , Resseguier Noémie , Brévaut-Malaty Véronique , Marret Stéphane , Cambonie Gilles , Souksi-Medioni Isabelle , Müller Jean-Baptiste , Garcia Patricia , Berbis Julie , Tosello Barthélémy , Auquier Pascal 
Published: June 2018

Objective

To determine the quality of life (QoL) of school-aged children who were born <28
+0
weeks of gestation and who have no resultant major disabilities.

Design, setting and patients

A cross-sectional multicentre study of extremely preterm (EPT) infants born <28
+0
weeks, discharged alive and free from severe impairments (cerebral palsy, autism, major cognitive disabilities). Two generic, self-evaluation and hetero-evaluation (by parent) QoL measurement questionnaires (Kidscreen 10/VSP-A) were used and then compared with French population reference.

Main outcome measures
Clinical examination, an assessment of cognitive functions and QoL between 7 and 10 years of age.

Results
40 (7.5%) severely disabled children were excluded. Among those 471 eligible, the lost to follow-up group (169 (36%)) paralleled those 302 (64%) included in the study. The mean gestational age was 26.2 (±0.8), birth weight was 879 (±181) g and the mean age was 8.4 (±0.87) years. 48% of participants had minor or moderate cognitive disabilities based on their Full-Scale Index Quotient. Working memory, attention and mental flexibility scored as low-average. Except for family relationships, the EPT QoL VSP-A and Kidscreen 10 assessment were significantly lower based on the children’s and parent’s perspectives. Children reported the most significant QoL decline as (1) friends’ relationships, (2) self-esteem and (3) leisure, while parents indicated (1) psychological well-being, (2) schoolwork and (3) vitality.

Conclusion
The QoL of a school-age EPT child without severe impairment was lower relative to a reference population from both the parents’ and child’s points of view. This evaluation should help to better understand the long-term outcomes and to provide better support for them and their families.

Trial registration number

NCT01675726
, pre-results.
Sex differences in utilisation of hospital care in a state-sponsored health insurance programme providing access to free services in South India
Authors: Shaikh Maaz , Peters Sanne A E , Woodward Mark , Norton Robyn , Jha Vivekanand 
Published: June 2018

BackgroundUniversal healthcare coverage provides healthcare and financial protection to all citizens and might help to facilitate gender equity in care. We assessed the utilisation of hospital care services among women and men in a large underprivileged population with access to free hospital care in India.MethodsThe Rajiv Aarogyasri Community Health Insurance Scheme, a state-sponsored scheme, provided access to free hospital care for poor households across undivided Andhra Pradesh. Claims data for hospitalisations between 2008 and 2012 were analysed to determine the number of individuals, hospitalisations, bed-days and hospital expenditure for sex-specific and sex-neutral conditions, by sex, disease category and age group.ResultsA total of 961 442 individuals (43% women), 1 223 723 hospitalisations (48% women), 7.7 million bed-days (47% women) and hospital expenditure of US$579.3 million (42% women) were recorded. Sex-specific conditions accounted for 27% of hospitalisations, 12% of bed-days and 15% of costs for women, compared with 5%, 4% and 4% in men. Women had a lower share of hospitalisations (42%), bed-days (45%) and costs (39%) for sex-neutral conditions than men. These findings were observed across 14 of 18 disease categories and across all age groups, but especially for older and younger women.InterpretationIn this large underprivileged population in India with access to free hospital care, utilisation of hospital care differed for women and men. For sex-neutral conditions, women accessed a smaller proportion of care than men, suggesting that coverage of hospital care alone is not sufficient to guarantee gender equity in access to healthcare.
Does gentle assisted pushing or giving birth in the upright position reduce the duration of the second stage of labour? A three-arm, open-label, randomised controlled trial in South Africa
Authors: Hofmeyr G Justus , Vogel Joshua P , Singata Mandisa , Habib Ndema Abu , Landoulsi Sihem , Gülmezoglu A Metin 
Published: June 2018

IntroductionGentle assisted pushing (GAP) is an innovative method of applying gentle, steady pressure to a woman’s uterine fundus during second stage of labour. This randomised trial evaluated GAP in an upright position, compared with upright position alone or routine practice (recumbent posture).MethodsAn open-label, hospital-based, randomised trial was conducted in Eastern Cape, South Africa. Randomisation occurred following at least 15 min in second stage of labour. Participants were randomly assigned (1:1:1) using computer-generated block randomisation of variable size using opaque, sealed, numbered envelopes. Primary analysis was intention to treat. Participants were healthy, nulliparous, consenting women with a singleton pregnancy in cephalic presentation where vaginal birth was anticipated. The primary outcome was mean time from randomisation to birth.Results1158 participants were randomly allocated to GAP (n=388), upright position (n=386) and routine practice (n=384), with no loss to follow-up. Baseline characteristics were largely similar. In the experimental arm, GAP was applied a median of two times (IQR 1.0–3.0). Women in upright position alone spent a median of 6 min (IQR 3.0–10.0) upright. Mean duration from randomisation to birth was not different across groups (mean (SD) duration: 24.1 (34.9) min in GAP group, 24.6 (30.5) min in upright group, 25.0 (39.3) min in routine practice group). There were no differences in secondary outcomes, except that at two sites maternal discomfort was greater for both GAP and upright position compared with routine practice; at the other sites there were no differences.ConclusionNo benefit was identified from GAP in the second stage; some women found the position uncomfortable. The use of fundal pressure should be limited to further research to determine techniques or settings in which it can safely assist vaginal birth. Women should be encouraged to assume the position they find most comfortable.Trial registration numberPACTR201502001034448.