bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using liberal–legal tools for illiberal gains: the European Court of Human Rights and legal mobilisation by conservative right-wing actors
Authors: Blokker Paul 
Published: November 2024

AbstractThe role of social movements and civil society actors in rights advancement has been frequently emphasised. The assumption is that legal mobilisation by civil society actors works towards the extension of rights and the emancipation and advancement of justice for distinctive (minority) groups in society. While traditionally, socio-legal attention on social movement and civil society actions around rights promotion was particularly prominent in the US, for some time now the European context has also been approached from such a socio-legal lens. However, a one-sided, liberal–progressive understanding of social mobilisation around rights has, importantly, been put to the test by recent manifestations of societal actors. Conservative actors tend to (1) promote a restrictive interpretation or a radical reinterpretation of existing rights (e.g. abortion, free speech), (2) limit the diffusion of new rights (e.g. the rights to euthanasia or legalizing surrogate maternity) and/or (3) call for the interruption of the further extensions of rights (e.g. with regard to same-sex marriage, LGBTIQ issues). The analysis of legal mobilisation by such conservative right-wing actors indicates that mobilisational repertoires are strikingly similar to those of liberal actors. This article will discuss the notions of civil society and legal mobilisation and call for a rethinking of these concepts, in part because of the increasing manifestation of societal actors that are in contrast to the traditional liberal paradigm. The article will subsequently engage in a detailed study of one such actor – the Polish legal think tank Ordo Iuris (OI) – with regard to its third-party or amicus curiae interventions at the European Court of Human Rights (ECtHR), stressing the difference of orientation of such interventions from those of liberal actors and also indicating dimensions of ambivalence and similarity in their approaches.
Ethnic diversity and political trust at the onset of the COVID-19 pandemic
Authors: Schraff Dominik , Hegewald Sven 
Published: November 2024

AbstractCurrent research faces challenges in explaining how contextual factors account for variations in the rally effect in political trust during the COVID-19 pandemic. While systematic explanations of country-level differences are hard to establish by means of cross-sectional comparisons, we propose to compare subnational areas within a country to learn more about the role of contextual factors. In this research note, we argue that ethnic diversity is a crucial contextual factor that helps researchers understand differences in political trust at the onset of the pandemic. Specifically, we propose that the rally effect should be restricted to ethnically more homogeneous contexts. An analysis of geocoded household panel data from the Netherlands reveals a strong rally effect in ethnically homogenous areas, while political trust in ethnically diverse contexts appears not to respond to the pandemic. This suggests an entrenched geography of political trust, which is associated with ethnic divides and is even maintained under crisis.
Observational Constraints on the Spatial Effect of Greenness and Canopy Cover on Urban Heat in a Major Midlatitude City
Authors: Lee Jangho , Berkelhammer Max 
Published: November 2024

AbstractUrban heat stress is a critical issue, particularly in cities where dense infrastructure and limited green space exacerbate temperature extremes. This study investigates the impact of greenery (EVI2), canopy cover (CC), impervious cover (IC), and water bodies on heat index in Chicago using high‐resolution data from the Heat Watch campaign. We find that EVI2, CC and proximity to water body significantly reduce heat while IC increases heat, particularly in the afternoon when solar radiation is intense. Additionally, the effective radius that land cover impacts heat is smaller in the afternoon. The combined effect analysis indicates that enhancing total greenness, not just canopy cover, is the most effective strategy to reduce heat. This study underscores the importance of strategic vegetation management, highlighting the critical role of integrated approaches in reducing urban heat.
A Mystery of the Inconsistency Between Microwave Polarimetric Observations and Radiative Transfer Simulations
Authors: Zhu Ziqiang , Weng Fuzhong 
Published: November 2024

AbstractA factor of 2 difference is found between microwave brightness temperature (TB) observations and simulations from vector radiative transfer models. A physical explanation of this difference is related to the calibration process. In principle, for the calibration of polarimetric instruments of a total power radiometer, the radiation should be only half of the values derived from Planck function but in the actual calibration process, a full value is used. When this full value is converted to a TB it is approximately, but not exactly, twice the TB simulated by a vector radiative transfer model. This inconsistency is verified by simulations of three conically scanning microwave imagers (WindSat, AMSR2 and MWRI) and one cross‐track scanning microwave sounder (AMSU‐A). This difference cannot be compensated simply by dividing a factor of 2 to the processed TBs, especially at high frequencies or at low physical temperatures due to the nonlinear property of Planck function.
Impact of the Offshore Seismograph Network and 3‐D Seismic Velocity Structure Model on Centroid Moment Tensor Analysis for Offshore Earthquakes: Application to the Japan Trench Subduction Zone
Authors: Yamaya Lina , Kubo Hisahiko , Shiomi Katsuhiko , Takemura Shunsuke 
Published: November 2024

AbstractRecently, a widespread and densely continuous‐recording ocean‐bottom seismograph network has been deployed in the Japan Trench subduction zone. Utilizing the offshore network data improves azimuthal station coverage for offshore earthquakes in the Japan Trench subduction zone. It has a potential to obtain centroid moment tensor (CMT) solutions more accurately than conventional analyses using onshore networks and a simple one‐dimensional seismic velocity structure model. In this study, we conducted CMT inversion for subduction zone earthquakes that occurred between 1 April 2017, and 31 March 2024, with a moment magnitude range of 5.2–7.0. We used seismograms obtained from both the offshore and onshore networks. We calculated Green's functions using a three‐dimensional seismic velocity structure model. Our CMT solutions with thrust‐type mechanisms mostly indicated depths and dip angles consistent with the plate interface. For earthquakes in the outer‐rise region, our CMT solutions were characterized as normal‐fault mechanisms. The joint use of the offshore and onshore networks reduced the estimation errors of the CMT solutions compared with the only use of the onshore network, although the optimal solutions were consistent. The dip angles for the thrust earthquakes determined by our analysis were more consistent with the dip angle of the plate boundary than those determined by conventional CMT analyses. Additionally, we found that the conventional CMT analysis could introduce a systematic bias in depth and magnitude determinations. This finding highlights the importance of an offshore seismograph network and a reliable seismic velocity structure model for CMT inversions.
Intensification of an Autumn Tropical Cyclone by Offshore Wind Farms in the Northern South China Sea
Authors: Deng Shaokun , Chen Shengli , Sui Yi , Hu Zhen‐Zhong 
Published: November 2024

AbstractThe rapid development of the wind industry is accompanied by increasing environmental impacts. Currently, there is a lack of research on the impacts of offshore wind farm (OWF) on tropical cyclone (TC) intensity, including the mechanisms involved. This research is carried out by using a coupled and an uncoupled numerical model to investigate the impact of OWF on an autumn TC in the northeastern South China Sea. The results show that the wind speed deficit caused by OWF leads to an increase in surface pressure on the inflow side. This causes the surface pressure in the TC periphery to increase by advection, even if the TC is some distance away from the OWF. The increase in pressure gradient from the periphery to the TC center enhances the TC secondary circulation, thereby intensifying the TC. When the TC enters the OWF, the above mechanisms weaken and the ocean dominates the TC intensification. This is because the reduction in wind speed caused by the OWF results in a weaker sea surface current velocity, which weakens the flow of upstream cold water into the OWF, warming the sea surface temperature (SST) within the OWF. This implies that the horizontal gradient of the local SST is an important factor to be considered in the development of OWF. Sensitivity experiments indicate that OWF can also intensify other types of TC, and that higher cut‐out wind speeds lead to stronger intensification effects. These results also provide a new perspective on TC intensity forecasts.
Greenhouse Warming Potential of a Suite of Gas Species on Early Mars Evaluated Using a Radiative‐Convective Climate Model
Authors: Jorge Jason , Wordsworth Robin , Adams Danica 
Published: November 2024

AbstractAbundant geomorphological and geochemical evidence of liquid water on the surface of early Mars during the late Noachian and early Hesperian periods needs to be reconciled with a fainter young Sun. While a dense atmosphere and related warming mechanisms are potential solutions to the early Mars climate problem, further investigation is warranted. Here, we complete a comprehensive survey of the warming potential of all known greenhouse gases and perform detailed calculations for 15 different minor gas species under early Martian conditions. We find that of these 15 species, , , , , and cause significant greenhouse warming at concentrations of 0.1 ppmv or greater. However, the most highly effective greenhouse gas species also tend to be more condensable, soluble and vulnerable to photolytic destruction. To provide a reference for future atmospheric evolution and photochemical studies, we have made our warming potential database freely available online.
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
Authors: Giuranna Johanna , Zheng Yiran , Brandt Matthäus , Jall Sigrid , Mukherjee Amrita , Shankhwar Soni , Renner Simone , Kurapati Nirup Kumar , May Caroline , Peters Triinu , Herpertz-Dahlmann Beate , Seitz Jochen , de Zwaan Martina , Herzog Wolfgang , Ehrlich Stefan , Zipfel Stephan , Giel Katrin , Egberts Karin , Burghardt Roland , Föcker Manuel , Marcus Katrin , Keyvani Kathy , Müller Timo D. , Schmitz Frank , Rajcsanyi Luisa Sophie , Hinney Anke 
Published: November 2024

AbstractThe C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did a mutation analysis in CTBP2 by performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant for AN and body weight regulation and ensued functional studies. Analysis of the coding regions of CTBP2 in 462 female patients with AN (acute or recovered), 490 children and adolescents with severe obesity, 445 healthy-lean adult individuals and 168 healthy adult individuals with normal body weight detected 24 variants located in the specific exon of RIBEYE. In the initial analysis, three of these were rare non-synonymous variants (NSVs) detected heterozygously in patients with AN (p.Arg72Trp - rs146900874; p.Val289Met -rs375685611 and p.Gly362Arg - rs202010294). Four NSVs and one heterozygous frameshift variant were exclusively detected in children and adolescents with severe obesity (p.Pro53Ser - rs150867595; p.Gln175ArgfsTer45 - rs141864737; p.Leu310Val - rs769811964; p.Pro397Ala - rs76134089 and p.Pro402Ser - rs113477585). Ribeye mRNA was detected in mouse hypothalamus. No effect of fasting or overfeeding on murine hypothalamic Ribeye expression was determined. Yet, increased Ribeye expression was detected in hypothalami of leptin-treated Lepob/ob mice. This increase was not related to reduced food intake and leptin-induced weight loss. We detected rare and frequent variants in the RIBEYE specific exon in both patients with AN and in children and adolescents with severe obesity. Our data suggest RIBEYE as a relevant gene for weight regulation.
Model-based characterization of total serum bilirubin dynamics in preterm infants
Authors: Chen Meng , Beuchée Alain , Levine Emmanuelle , Storme Laurent , Gascoin Geraldine , Hernández Alfredo I. 
Published: November 2024

Abstract

Objectives
This study aims to characterize the age-related natural dynamics of total serum bilirubin (TSB) in preterm infants through a mathematical model and to study the model parameters as potential biomarkers for detecting associated morbidities.

Methods
We proposed an exponential decay model and applied it to each infant. Patient-specific parameters were obtained by minimizing the error between measured TSB and model output. Modeling evaluation was based on root-mean-square error (RMSE). The occurrence of high-risk clinical events was analyzed based on RMSE.

Results
In a subset of the CARESS-Premi study involving 373 preterm infants (24–32 weeks’ gestation), 72 patient-specific models were fitted. RMSE ranged from 1.20 to 40.25 µmol/L, with a median [IQR] of 8.74 [4.89, 14.25] µmol/L.

Conclusions
Our model effectively characterized TSB dynamics for 72 patients, providing valuable insights from model parameters and fitting errors. To our knowledge, this is the first long-term mathematical description of natural TSB decay in preterm infants. Furthermore, the model was able to estimate the occurrence of clinical events such as necrotizing enterocolitis, as reflected by the relatively high RMSE. Future implications include the development of model-based clinical decision support systems for optimizing NICU monitoring and detecting high-risk events.

Impact

The study characterizes the natural dynamics of total serum bilirubin in preterm infants (24–32 weeks’ gestation) using a patient-specific exponential decay model.

The model describes patient-specific patterns of TSB evolution from day three to the first weeks, providing a median [IQR] root-mean-squared error of 8.74 [4.89, 14.25] µmol/L.

Complementary to previous studies focusing on the first 72–96 h, our study emphasizes the later decay course, contributing to a comprehensive long-term characterization of the natural TSB dynamics in preterm infants.

The proposed model holds potential for clinical decision support systems for the optimization of NICU monitoring and high-risk event detection.
Genetic engineering and the eye
Authors: Murphy Rory , Martin Keith R. 
Published: November 2024

Abstract
The transformative potential of genetic engineering in ophthalmology is remarkable, promising new treatments for a wide range of blinding eye diseases. The eye is an attractive target organ for genetic engineering approaches, in part due to its relatively immune-privileged status, its accessibility, and the ease of monitoring of efficacy and safety. Consequently, the eye has been at the forefront of genetic engineering advances in recent years. The development of Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9), base editors, prime editors, and transposases have enabled efficient and specific gene modification. Ocular gene therapy continues to progress, with recent advances in delivery systems using viral / non-viral vectors and novel promoters and enhancers. New strategies to achieve neuroprotection and neuroregeneration are evolving, including direct in-vivo cell reprogramming and optogenetic approaches. In this review, we discuss recent advances in ocular genetic engineering, examine their current therapeutic roles, and explore their potential use in future strategies to reduce the growing burden of vision loss and blindness.
Estimation of Jacquard’s genetic identity coefficients with bi-allelic variants by constrained least-squares
Authors: Graffelman Jan , Weir Bruce S. , Goudet Jérôme 
Published: November 2024

AbstractThe Jacquard genetic identity coefficients are of fundamental importance in relatedness research. We address the estimation of these coefficients as well as other relationship parameters that derive from them such as kinship and inbreeding coefficients using a concise matrix framework. Estimation of the Jacquard coefficients via likelihood methods and the expectation–maximization algorithm is computationally very demanding for large numbers of polymorphisms. We propose a constrained least squares approach to estimate the Jacquard coefficients. A simulation study shows constrained least squares achieves root-mean-squared errors that are comparable with those of the maximum likelihood approach, in particular when founder allele frequencies are unknown, while obtaining enormous computational savings.
Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
Authors: Wang Xianping , Guo Yifan , Lin Peng , Yu Min , Song Sha , Xu Wenyan , Kong Du , Wang Yin , Zhang Yanxiao , Lu Fei , Xie Qi , Ma Xianjue 
Published: November 2024

AbstractHormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition of steroid hormone signaling remain poorly understood. Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets reveals that overexpression of the nuclear receptor E75, particularly facilitates the malignant transformation of benign tumors. Genome-wide DNA binding profiles and biochemistry data reveal that E75 not only binds to the transcription factors of both Hippo and Notch pathways, but also exhibits widespread co-binding to their target genes, thus contributing to tumor malignancy. We further validated these findings by demonstrating that depletion of NR1D2, the mammalian homolog of E75, inhibits the activation of Hippo and Notch target genes, impeding glioblastoma progression. Together, our study unveils a novel mechanism by which hormone inhibition promotes tumor malignancy, and describes an evolutionarily conserved role of the oncogene E75/NR1D2 in integration of Hippo and Notch pathway activity during tumor progression.
Structural basis of 3′-tRNA maturation by the human mitochondrial RNase Z complex
Authors: Valentín Gesé Genís , Hällberg B Martin 
Published: November 2024

AbstractMaturation of human mitochondrial tRNA is essential for cellular energy production, yet the underlying mechanisms remain only partially understood. Here, we present several cryo-EM structures of the mitochondrial RNase Z complex (ELAC2/SDR5C1/TRMT10C) bound to different maturation states of mitochondrial tRNAHis, showing the molecular basis for tRNA-substrate selection and catalysis. Our structural insights provide a molecular rationale for the 5′-to-3′ tRNA processing order in mitochondria, the 3′-CCA antideterminant effect, and the basis for sequence-independent recognition of mitochondrial tRNA substrates. Furthermore, our study links mutations in ELAC2 to clinically relevant mitochondrial diseases, offering a deeper understanding of the molecular defects contributing to these conditions.
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis
Authors: Trasser Marieke , Bohl-Viallefond Grégoire , Barragán-Borrero Verónica , Diezma-Navas Laura , Loncsek Lukas , Nordborg Magnus , Marí-Ordóñez Arturo 
Published: November 2024

AbstractTransposable elements (TEs) are repressed in plants through transcriptional gene silencing (TGS), maintained epigenetic silencing marks such as DNA methylation. However, the mechanisms by which silencing is first installed remain poorly understood in plants. Small interfering (si)RNAs and post-transcriptional gene silencing (PTGS) are believed to mediate the initiation of TGS by guiding the first deposition of DNA methylation. To determine how this silencing installation works, we took advantage of ÉVADÉ (EVD), an endogenous retroelement in Arabidopsis, able to recapitulate true de novo silencing with a sequence of PTGS followed by a TGS. To test whether PTGS is required for TGS, we introduce active EVD into RNA-DEPENDENT-RNA-POLYMERASE-6 (RDR6) mutants, an essential PTGS component. EVD activity and silencing are monitored across several generations. In the absence of PTGS, silencing of EVD is still achieved through installation of RNA-directed DNA methylation (RdDM). Our study shows that PTGS is dispensable for de novo EVD silencing. Although we cannot rule out that PTGS might facilitate TGS, or control TE activity, initiation of epigenetic silencing can take place in its absence.
Secrecy outage probability of IRS‐aided VLC systems with power splitting
Authors: Zhao Xiang , Zhang Xinyuan , Liu Maoyu , Sun Jinyong 
Published: November 2024

AbstractAn intelligent reflecting surface (IRS)‐aided visible light secure communication system is investigated. In order to improve its security performance, a power splitting scheme is adopted at the light‐emitting diodes. In contrast to most current research on the physical‐layer security in IRS‐aided visible light secure communication systems where secrecy rate or secrecy capacity maximization problems subject to various resource constraints were formulated, this letter takes the reliability of secure transmission into account. The closed‐form expression of secrecy outage probability is derived based on the statistical characteristics of the signal‐to‐noise ratio of the legitimate user, and the effects of light‐emitting diodes and IRS parameters and power splitting ratio on the secrecy outage probability are validated through simulations.
A collaborative planning of PCCs siting and transmission network expansion for super large‐scale offshore wind clusters
Authors: Ling Jingwen , Bian Xiaoyan , Yang Yue , Xu Ling , Zhang Mengyao , Liu Zhong 
Published: November 2024

AbstractThe integration of super large‐scale offshore wind clusters into the onshore power grid brings challenges for the flexibility of the transmission network. Therefore, this paper proposes a two‐stage collaborative planning of points of common coupling siting and transmission network expansion for super large‐scale offshore wind clusters, based on a multi‐voltage‐level stratified integration mode which enables offshore wind power to transmit to larger regions for accommodation. At first, the transmission network flexibility indexes are established. Then, a two‐stage collaborative planning model for points of common couplings siting and transmission network expansion is proposed, which comprises a collaborative planning model and an optimal power flow operation model. The proposed model reduces wind curtailment and load shedding by optimizing the annual total cost and flexibility transmission capability of the network. Finally, the effectiveness of the proposed method is verified using a modified IEEE 30‐bus system and a 65‐bus system.