bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of famotidine in combination with antiepileptic drugs on locomotor activity in mice
Authors: Swiader Mariusz J. , Swiader Katarzyna , Zakrocka Izabela , Munir Darin 
Published: April 2019

Abstract
Histamine type 2 receptor antagonists are one of the most commonly used agents to treat peptic ulcer disease. Since patients with epilepsy may have many comorbidities, the aim of this study was to investigate the influence of one of the strongest second generation histamine type 2 receptor antagonist, famotidine, on the exploratory and spontaneous activity in mice after 1 or 7 days treatment. Additionally, the interaction between famotidine and antiepileptics: carbamazepine, phenytoin, phenobarbital or valproate and their effect on animals activity was also evaluated. Locomotor activity was monitored electronically using a Digiscan analyzer in relation to ambulatory and rearing activities, as well as total distance travelled by animals during 15 minute periods. Results of our study indicate that famotidine administered alone did not modulate three variables of exploratory motor activity (horizontal activity, total distance and vertical activity) in mice. On the other hand, famotidine co-administered with valproate (1 day) or phenobarbital (1 day or 7 days) worsened vertical activity in mice in exploratory time. Similarly, impairment in horizontal activity in mice was observed when famotidine was given with phenobarbital (1 or 7 days). An increase in total distance in mice after famotidine alone or in combination with tested antiepileptic drugs was also shown. Moreover, famotidine alone or together with antiepileptic agents significantly impaired spontaneous locomotor activity in mice. The presented results show that famotidine administration to patients with epilepsy should be considered as potentially hazardous.
Increasing efficacy of treatment in patients with steatohepatitis and concomitant chronic colitis
Authors: Manzhalii Elina G. , Moyseyenko Valentyna O. , Falalyeyeva Tetyana M. , Tsyryuk Olena I. , Kondratiuk Vitaliy E. , Nykula Taras D. 
Published: April 2019

Abstract
This paper presents the results of a study of patients with nonalcoholic steatohepatitis, alcoholic steatohepatitis, and drug-induced liver injury with concomitant colitis and the development of biliary insufficiency that manifests as a significant decrease in the volume of bile acids and bile. In patients with liver injury and concomitant colitis, changes in intestinal microflora were marked. After a combination therapy of this pathology with phosphatidylcholine and glycyrrhizic acid, an improvement of biochemical, clinical indicators was observed, as well as a decrease in fatty degeneration and reduction of elastographic indicators of liver fibrosis. The introduction of the drug formulations phosphatidylcholine and glycyrrhizic acid in the complex of conservative treatment of liver injury with concomitant colitis helps to prevent hepatic and intestinal complications and to increase the treatment efficacy of these diseases.
Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite
Authors: Safaei Mohsen , Taran Mojtaba , Rezaei Razieh , Mansouri Kamran , Mozaffari Hamid Reza , Imani Mohammad Moslem , Sharifi Roohollah 
Published: April 2019

Abstract
Given the increase in global mortality rate due to various types of cancer, the present study aimed to develop optimal conditions for the synthesis of cellulose-magnesium oxide nanocomposite with favorable anticancer activity. For this purpose, the Taguchi method was used to design nine experiments with varied ratios of cellulose biopolymer, magnesium oxide nanoparticles and different stirring times. The scanning electron microscopy (SEM) images confirmed the formation of cellulose-magnesium oxide nanocomposite. The anticancer activity level of nine nanocomposites studied was evaluated using MTT assay on Michigan Cancer Foundation-7 (MCF-7) cell line. The nanocomposite synthesized in experiment 9 (8 mg/ml of magnesium oxide, 2 mg/ml of cellulose and stirring time of 60 min) showed the highest growth inhibitory activity on the cancer cells. Based on the attained results,e cellulose-magnesium oxide nanocomposite synthesized in optimal conditions can be used as an eligible anticancer agent.
Origins, pathophysiology, diagnosis, vaccination and prevention of Chikungunya virus
Authors: Rafe Md. Rajdoula , Ahmed Syeda Naureen , Ahmed Zebunnesa 
Published: April 2019

Abstract
Chikungunya virus is an Alphavirus that possesses characteristics similar to that of an arthropod-borne virus. Chikungunya virus has been one of the major concerns for the last few decades due to its nature of explosive spreading throughout the world. This article is intended to give detailed information about Chikungunya virus, and includes its pathogenesis, origins, diagnosis, treatment and prevention. Although, recent researches suggests various approaches to treating Chikungunya virus, extensive literature search on Chikungunya virus has revealed that, currently, there is no effective treatment available and the virus is greatly dependent on its vectors. Patients affected by Chikungunya virus mainly show symptoms of fever, arthralgia, joint pain and skin rash. Since there is no effective treatment available, public awareness is the most significant factor for potential prevention against Chikungunya virus.
Chromone-3-aldehyde derivatives – sirtuin 2 inhibitors for correction of muscular dysfunction
Authors: Pozdnyakov Dmitry I. , Voronkov Andrey V. , Rybalko Anastasiya E. , Rukovitsyna Viktoriya M. , Oganesyan Eduard T. 
Published: April 2019

Abstract

The aim of the study was to evaluate experimentally, the myoprotective effect of new chromone-3-aldehyde derivatives in conditions of muscular dysfunction and to establish a potential mechanism of myoprotective activity – the blockade of the function of sirutin 2. Materials and methods. The effect of new chromone-3-aldehyde derivatives on the development of muscular dysfunction under the conditions of an electromiostimulation test, was studied. The degree of muscle fatigue was evaluated in the «grip-strength» and through test biochemical assays (determination of the activity of lactate dehydrogenase, creatine kinase, concentration of lactic and pyruvic acids, creatinine, myoglobin, and total protein) to determine the possible mechanism of action of the test compounds (5 new derivatives of chromone-3-aldehyde) and their effect on the function of sirtuin 2 was evaluated.

Results. The study showed that chromone-3-aldehyde derivatives have a pronounced myoprotective effect associated with low toxicity (class 5 toxicity according to the GHS classification), which was confirmed by the results of the «grip-strength» test and biochemical tests data. Test compounds under the X3AC1, X3AOAC and X3AN codes evince sirtuin 2 inhibitory activity, which was reflected in a decrease in its concentration by 63.6% (p <0.05); 130.2% (p <0.05) and 218.8% (p <0.05).

Conclusion. The study showed that chromone-3-aldehyde derivatives are promising subjects for further study with the goal of creating a drug with a high myoprotective effect and an optimal safety profile.
Editorial 2019: Continuation of Promotion and New Efforts
Authors: Tomljanović Tea , Matulić Daniel 
Published: April 2019

Abstract
Croat J Fish continues in its effort to stay an important scientific and professional journal in the region. In this year, the Journal was advanced by new Editorial Board members while cooperation with SCIENDO publishers has been extended until the end of 2020. We hope and expect 2019 to be yet another significant year in fisheries science and we look forward to sharing it with you. The Editorial also provides information on the latest news on Open Access Journals Initiative, the Journal Scopus CiteScore metrics, as well as the articles published in Croat J Fish in 2018, with a list of reviewers who participated in the review process.
Morphological Differences and Trophic Niche Breadth of Sarotherodon galilaeus and Oreochromis niloticus from the Freshwater Lake Geriyo, North-Eastern Nigeria
Authors: Chukwuka Azubuike Victor , Adebowale Adedeji Hameed , Adekolurejo Oloyede Adeyemi 
Published: April 2019

Abstract
The relationship between morphological traits and feeding ecology of the only two tilapiine cichlids (Sarotherodon galilaeus and Oreochromis niloticus) in Lake Geriyo, northeastern Nigeria, was examined. Stomach contents of 504 individuals were examined and analyzed to relate morphological differences of each species to its dietary preferences. Eleven ecological relevant morphological variables, including total length, standard length, head length, body depth, eye diameter, pectoral spine length, pelvic spine length, dorsal fin ray count, dorsal spine count and anal fin ray count, were also measured and subjected to Principal coordinate analysis (PCoA) to relate morphological differences of each species to its dietary preferences. The PCoA (using Euclidean distance) revealed a large morphological distance between species indicating adaptation for different spatial and vertical distributions within the lake. Furthermore, the correlation of these morphological differences with particular diet categories suggests a potential for specialized trophic tendencies, however, the high occurrence of two major food types (macrophytes and plankton) in stomach contents of both species indicate generalist trophic tendencies. While a high trophic overlap index (0.98) was recorded for both species, the trophic niche breadth was higher for S. galilaeus (4.18±0.32), compared to O. niloticus (3.33±0.24). Despite the large morphological differences of both tilapias, the high trophic overlaps indicate limited food options within Lake Geriyo. In addition, the successful coexistence of the tilapias in the face of limited food resources indicates suitable partitioning of food resources in the lake.
Genetic Diversity and Population Structure Analyses of Threatened Amblyceps mangois from Sub-Himalayan West Bengal, India Through Rapd and ISSR Fingerprinting
Authors: Mukhopadhyay Tanmay , Bhattacharjee Soumen 
Published: April 2019

Abstract

Amblyceps mangois or the “Indian torrent catfish” is a tropical, freshwater, hill-stream species that has ornamental-commercial value and has been included within the “Endangered” category in the list of threatened freshwater fishes of India. A total fourteen populations from the Terai and Dooars region of northern West Bengal, India were analyzed to study the genetic architecture of this species with the help of RAPD and ISSR markers. The observed number of alleles (S), Nei’s gene diversity (H) and Shannon’s information index (H´ or I) showed the highest values in the Teesta river system and the lowest values in the Mahananda river system. The UPGMA-based dendrogram and PCoA, based on RAPD and ISSR fingerprints, showed that the Mahananda and the Teesta river populations formed a group distinct from the remaining Jaldhaka river population. We further considered the fourteen riverine populations into nine groups according to the continuity of the water flow for SHE analysis. It was found that the three components, i.e. the pattern of diversity (H´), richness (S) and evenness (E), have varied and fluctuated across all fourteen populations from higher to lower altitude as the river flows downstream. AMOVA, PhiPT and genetic hierarchical analyses showed that a distinct hierarchical structure is present in Amblyceps populations in the study region. Low levels of genetic diversity/variation and genetic hierarchical structure with high genetic divergence were found in the present study as an indicator of the recent picture of threatened status of this species. This study is the initial attempt to characterize and evaluate the genetic architecture of the species from this region and there is a scope to manage the evolutionary significant units (ESU) for conservation purpose.
Ukrainians in Slovakia: Outlining the Reflection on Ethnic Identity and Autostereotypisation of the Ukrainian Minority
Authors: Součková Taťána 
Published: April 2019

Abstract
The paper is based on the conclusions of ethnological research of Ukrainian minority carried out by the author on the territory of Slovakia between 2014 and 2016. Its main objective was the reflection of ethnic stereotypes of the Ukrainian minority towards the Slovak majority. An unavoidable element in research on stereotyping and reflection of “national character” was also an analysis of ethnic identity of the members of the minority group. How do they perceive themselves, what does it personally mean to them to be a Ukrainian and what practically fulfills an abstract category of “being Ukrainian”. The author briefly summarizes key theoretical objectives of the concept of ethnic identity and then analyses its reflection within the Ukrainians in Slovakia with regard to its main characteristics. Ukrainian autostereotypisation in the broader context of Ukrainian-Russian relatioship is also examined.
Once We Were Shepherds: Górale Ethnic Identity in Celebrations Revived and Reinterpreted
Authors: Sendyka Pawel 
Published: April 2019

Abstract
The Górale of the Polish highlands are seen as a people apart from the rest of Poles. They are afforded this special status through the romanticisation as Poland’s very own “noble savages” by the writers and travellers of the 19th century. This was the time of Poland’s search for nationhood (when its territory was occupied by Russia, Prussia and Austria). The Górale have always been described, even in those early accounts, as pastoralists.
During the season, when the sheep went up to the alpine pastures, the villages were almost deserted. In the 20th century the pastoral system dissolution took place starting with the establishment of national parks after the Second World War. Further unfavourable developments decimated what was left of it since the late 1980s. As a result of the dissolution of the pastoral system the Górale chose to amplify their internal unity by strengthening the ethnic identity. The revival of pastoralism as it currently presents itself today, may be seen as yet another rallying call around Górale identity. It is a come back to the pastoralist “core” of the highland culture, while changing and re-inventing the tradition to suit new economic, social and political circumstances.
In the Polish pastoralist tradition there have always been two seminal community events which bracketed the winter season. There was the autumn event of “Redyk Jesienny” when the sheep brought back from the summer alpine pastures were given back to their owners and there was also a spring event of “Mieszanie Owiec” which literally means the Mixing of Sheep. Historically, they were very important events of the pastoral calendar, while the pastoral system itself has been crucial fixture and backbone of the social system of the Górale people. The paper examines how these traditions changed from old ethnographic descriptions and how they are being re-invented in the context of reaffirming the Górale identity today.
Skin Bleaching Narratives Responses from Women Bleaches and Stakeholders in Ghana (1950s – 2015)
Authors: Adu-Gyamfi Samuel , Gyasi Razak Mohammed , oware Richard , Adu-Agyeman Godwin 
Published: April 2019

Abstract
Based on a qualitative design and a qualitative analysis of responses from primary informants and secondary sources we present a narrative on the attitudes and perception of the Ghanaian on skin bleaching. Based on retrospective and thematic analyses the authors conclude that there is the need for education and enforcement of laws that protect the consumer from patronizing cosmetics that bleach the skin. The study further highlights the role of institutions that are responsible for legislating, regulating, preventing and educating the general public. It is envisaged that this article shall reinvigorate the need for further research and discourses on skin bleaching in Africa and Ghana in particular. Policy makers and policy implementers should be spurred on to make a difference.
Food Festivals and Expectations of Local Development in Northern Italy
Authors: Fontefrancesco Michele Filippo 
Published: April 2019

Abstract
This essay offers an ethnographic analysis of the role of food in modern Italian food festivals. Starting from the ethnographic case of Borgonovo, a rural town in Southern Piedmont, and its festival, it highlights the nonlinear role played by food in the festivals and points out gastronomic festivals should be read as a local response of rural, and marginal communities to the phenomenon of their social marginalization.
Genetic variability in peas (Pisum sativum L.) from Turkey asssessed with molecular and morphological markers
Authors: Hanci Fatih 
Published: April 2019

Abstract
The aim of this study was to identify the molecular and morphological characteristics of Turkish pea accessions (Pisum sativum L.). The genetic diversity among 130 Turkish landraces and 2 commercial varieties in a total of 132 pea accessions was assessed with 14 simple sequence repeat (SSR) markers. Forty-eight (48) polymorphic alleles were identified using 14 SSR markers. The pairwise Dice coefficients of similarity between accessions ranged from 0.091 to 0.960. The polymorphism information content (PIC) value ranged from 0.585 to 0.861. Overall, 50 morphological traits were evaluated. Cluster analysis was carried out on a matrix of Euclidean distances. The accessions were divided into three main groups. Principal component analysis (PCA) was used to identify the weight of each morphological characteristic. According to the results, the highest eigenvalue was observed in PC-I (13.88) followed by PC-II (11.42), and PC-III (7.32). The first fifteen PCs with eigenvalues > 1 explained 74.08% of the variability. The results showed that the molecular markers were useful and polymorphic, sufficient to allocate all the evaluated accessions. This research has provided significant insights into the genetic variability of Turkish pea accessions.
Intusussception Secondary to Gastrointestinal Foreign Body in an Eleven Month old Juvenile African Lion (Panthera Leo) Case Report
Authors: Ajadi R. A. , Egbetade A. O. , Ajayi O. O. , Makinde O. A. , Okandeji M. E. 
Published: April 2019

Abstract
An eleven month old male, juvenile lion brought for rehabilitation at the Olusegun Obasanjo Presidential Library (OOPL) Wildlife Park was diagnosed with gastrointestinal foreign body and intussusception based on the history of persistent vomiting following ingestion of a cotton towel, and radiographic findings of a radiopaque gastric foreign body extending from the fundus to the pylorus and a cylindrical soft tissue mid-abdominal mass. The lion was premedicated with an intramuscular injections of ketamine (5 mg.kg−1) and midazolam (0.25 mg.kg−1), while anaesthesia was induced with an intravenous injection of propofol (2 mg.kg−1). A celiotomy followed by gastrotomy and subsequent intestinal resection and anastomosis was performed to remove the gastrointestinal foreign bodies and correct the intussus ception. The lion recovered well without any complication and was gradually introduced back into the group housing three weeks later following successful alimentation process. This report is probably the first case of intussusception in a lion that was associated with a gastrointestinal foreign body.
Effects of Cell Seeding Methods on Chondrogenic Differentiation of Rat Mesenchymal Stem Cells in Polyhydroxybutyrate/Chitosan Scaffolds
Authors: Giretová M. , Medvecký Ľ. , Petrovová E. , Čížková D. , Mudroňová D. , Danko J. 
Published: April 2019

Abstract
The aim of our study was to examine the effects of passive and active cell seeding techniques on in vitro chondrogenic differentiation of mesenchymal stem cells (MSC) isolated from rat bone marrow and seeded on porous biopolymer scaffolds based on polyhydroxybutyrate/chitosan (PCH) blends. This paper is focused on the distribution of the cells on and in the scaffolds, since it influences the uniformity of the created extracellular matrix (ECM), as well as the homogenity of the distribution of chondrogenic markers in vitro which ultimately affects the quality of the newly created tissue after in vivo implantation. The three types of cell-scaffold constructs were examined by: fluorescence microscopy, SEM, histology and quantitative analysis of the glycosaminoglycans after chondrogenic cultivation. The results demonstrated that the active cells seeded via the centrifugation of the cell suspension onto the scaffold guaranteed an even distribution of cells on the bulk of the scaffold and the uniform secretion of the ECM products by the differentiated cells.
Prevalence of Porcine Rotavirus Antigen and Associated Risk Factors in Pig-Raising Communities and Institutional Piggeries in Zaria, Kaduna State, Nigeria
Authors: Delia T. A. , Dzikwi-Emennaa A. A. , Kwaga J. K. P. , Kia G. S. N. , Olufemi O. T. , Otolorin G. R. , Adanu A. W. 
Published: April 2019

Abstract
Porcine rotaviruses are potential reservoirs for genetic exchange with human rotaviruses. A cross-sectional study was carried out to determine the prevalence of porcine Rotavirus antigen and associated risk factors in pig-raising communities and institutional piggeries in Zaria, Kaduna State, Nigeria. A total of 376 faecal samples from pigs of all ages were collected from backyard and institutional piggeries by convenience sampling. The faecal samples collected were analysed using commercially available ELISA kit: BioK 343/2, for the antigenic diagnosis of rotavirus in porcine faeces. The overall prevalence of rotavirus antigen in pigs was 9.8 % (37/376). Piglets (10.4 %) had a higher prevalence than adults (9.1 %), while males (10.1 %) were more infected than females (9.6 %). Breed-specific prevalences revealed 5.9 %, 12 % and 15.5 % for local, exotic and cross-breeds, respectively. There was a significant association between breed (P < 0.05) (Odds Ratio OR = 2.927; 95 % Confidence Interval CI on OR = 1.288—6.653) and rotavirus infection. Management system revealed 14 % and 8.2 % prevalence for intensive and semi-intensive systems, respectively. There is evidence of Rotavirus infection (9.8 %) in pigs in Zaria, and the breed is a risk factor. This study provides the first data on the prevalence of rotavirus and risk factors of rotavirus infection among pigs in Zaria and environs, Kaduna state, Nigeria. There is a need to enlighten the public on the zoonotic implication and economic impacts of rotavirus infections.
Ecological Factors of Transmission, Persistence and Circulation of Pathogens In Bat Populations
Authors: Zemanová S. , Korytár Ľ. , Benkő Z. , Prokeš M. , Ondrejková A. 
Published: April 2019

Abstract
The existence of bats is crucial for all ecosystem units as they fulfil numerous ecological roles. However, they are also considered to be natural reservoirs of a wide range of zoonotic microorganisms, especially viruses. In this review article we briefly summarize current knowledge about various ecological factors that facilitate bat pathogen dispersal and about the current approaches to monitoring viral communities present within bat populations. On the basis of the cited papers, we suggest that the increased focus on complex viral populations in bats and their interactions with other populations and the environment is necessary to fully comprehend the relationship between emerging infectious diseases, the environment and their toll on human health.