bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative mobile Raman study for the on field analysis of the Mosaico de los Amores of the Cástulo Archaeological Site (Linares, Spain)
Authors: Rousaki Anastasia , Costa Mafalda , Saelens Delphine , Lycke Sylvia , Sánchez Alberto , Tuñón José , Ceprián Bautista , Amate Pilar , Montejo Manuel , Mirão José , Vandenabeele Peter 
Published: May 2019

AbstractAn in situ archaeometrical campaign was organized in 2018 for the physicochemical analysis of the exceptional Mosaico de los Amores of the Cástulo archaeological site (Linares, Spain). Several mobile instruments were brought on the field to investigate the colourful tesserae of the mosaic. The main aim of the current research paper is the comparison of different mobile instruments and their applicability on measuring in open air environments. In this study, the comparison of four mobile Raman instruments, using different excitation lasers and technologies, is discussed. Three portable, the EZRaman‐I dual Raman analyser from TSI Inc. (USA), the i‐Raman® EX from BWTEK (USA), and the BWS445‐785S InnoRam™ Raman spectrometer from BWTEK (USA), and one handheld system, the Bravo Raman spectrometer from Bruker (Europe), are compared in terms of their characteristics, applicability, and performance when conducting non‐invasive and non‐destructive analysis.
Drought stress modulates secondary metabolites in Brassica oleracea L. convar. acephala (DC) Alef, var. sabellica L.
Authors: Podda Alessandra , Pollastri Susanna , Bartolini Paola , Pisuttu Claudia , Pellegrini Elisa , Nali Cristina , Cencetti Gabriele , Michelozzi Marco , Frassinetti Stefania , Giorgetti Lucia , Fineschi Silvia , Del Carratore Renata , Maserti Biancaelena 
Published: May 2019

AbstractBACKGROUNDConsumer preference today is for the consumption of functional food and the reduction of chemical preservatives. Moreover, the antimicrobial properties and health‐promoting qualities of plant secondary metabolites are well known. Due to forecasted climate changes and increasing human population, agricultural practices for saving water have become a concern. In the present study, the physiological responses of curly kale Brassica oleracea L. convar. Acephala (DC) var. sabellica to drought stress and the impact of water limitation on the concentration of selected secondary metabolites were investigated under laboratory‐controlled conditions.RESULTSResults indicated that drought stress increased the content of trans‐2‐hexenal, phytol and δ‐tocopherol, and decreased chlorophyll content. Moreover, drought stress increased antioxidant capacity and the expression of AOP2, a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates, and of three genes – TGG1, TGGE and PEN2 – encoding for myrosinases, the enzymes involved in glucosinolate breakdown.CONCLUSIONThe present study shows that water limitation during the growing phase might be exploited as a sustainable practice for producing curly kale with a high concentration of nutritionally important health‐promoting bioactive metabolites. © 2019 Society of Chemical Industry
Characterizing watercraft‐related mortality of sea turtles in Florida
Authors: Foley Allen M. , Stacy Brian A. , Hardy Robert F. , Shea Colin P. , Minch Karrie E. , Schroeder Barbara A. 
Published: May 2019

ABSTRACTMortality from being struck by a motorized watercraft is considerable for many aquatic vertebrates around the world, including sea turtles. We studied stranded (i.e., dead, sick, or injured) sea turtles found in Florida, USA, during 1986–2014 and identified those with sharp force or blunt force injuries indicative of a vessel strike. About a third of stranded loggerheads (Caretta caretta), green turtles (Chelonia mydas), and leatherbacks (Dermochelys coriacea) had a vessel‐strike injury (VSI). The frequency of this injury was lower but still substantial for stranded Kemp's ridleys (Lepidochelys kempii; 26.1%) and hawksbills (Eretmochelys imbricata; 14.8%). Over the study period, the annual number of stranded loggerheads, green turtles, and Kemp's ridleys with a VSI increased as did the annual number of vessels registered in Florida. Eighty‐one percent of the stranded turtles with a VSI were found in the southern half of Florida and 66% of those were found along the southeast coast. By coastal county, the proportion of stranded sea turtles with a VSI was positively related to the mean annual number of registered vessels. The percentage occurrence of a VSI was highest for adult loggerheads, green turtles, and leatherbacks, and reproductively active individuals appeared to be particularly vulnerable to these injuries. We conducted necropsies on 194 stranded sea turtles with a VSI and concluded that this injury was the cause of death or the probable cause of death in ≥92.8% of these cases. During 2000–2014, we estimate that the mean annual numbers of stranded sea turtles that died from a VSI were 142–229 loggerheads, 101–162 green turtles, 16–32 Kemp's ridleys, 4–6 leatherbacks, and 2–4 hawksbills. Considering that only about 10–20% of sea turtles that died likely washed ashore, the overall annual mortality may have been 5–10 times greater than that represented by strandings. Most of the significant clusters of stranded sea turtles with a VSI occurred at inlets or passes and the probability that a stranded sea turtle had a VSI decreased with increasing distance from inlets or passes, navigable waterways, and marinas. We suggest focusing initial management efforts on reducing watercraft‐related mortality for all sea turtle species around 8 inlets in southeast Florida, reproductively active loggerheads and green turtles along the coast of southeast Florida, and Kemp's ridleys and adult male loggerheads at passes along the coast of southwest Florida. Published 2019. This article is a U.S. Government work and is in the public domain in the USA. The Journal of Wildlife Management published by Wiley Periodicals, Inc. on behalf of The Wildlife Society
Fuzzy analytic hierarchy process‐integrated statistical process control: An application of demerit chart at furniture manufacturing company
Authors: Sagnak Muhittin , Kazancoglu Yigit 
Published: May 2019

AbstractStatistical process control techniques, especially control charts, have been popular tools for tracking and analysing the quality improvement process. Control charts make measurements in respect to the central line and the upper and lower control limits of a process and allow corrective action to be taken. It may be not adequate when the quality characteristics include properties requiring the usage of linguistic variables (e.g., very poor, poor, average, good, and very good) rather than identifying them just conforming or nonconforming. The demerit chart is a control chart for attributes that allows the arrangement of the relative exact weight (real number), consistent with the various levels of defects. In this paper, in order to hire linguistic weights, a demerit chart was integrated with fuzzy analytical hierarchy process, mainly through the determination of weights in accordance with the degrees of defects, after which the central line and upper and lower limits were calculated.
Identification of novel compound heterozygous mutations in ACO2 in a patient with progressive cerebral and cerebellar atrophy
Authors: Fukada Masahide , Yamada Keitaro , Eda Shima , Inoue Ken , Ohba Chihiro , Matsumoto Naomichi , Saitsu Hirotomo , Nakayama Atsuo 
Published: May 2019

AbstractBackgroundThe tricarboxylic acid (TCA) cycle is a sequence of catabolic reactions within the mitochondrial matrix, and is a central pathway for cellular energy metabolism. Genetic defects affecting the TCA cycle are known to cause severe multisystem disorders.MethodsWe performed whole exome sequencing of genomic DNA of a patient with progressive cerebellar and cerebral atrophy, hypotonia, ataxia, seizure disorder, developmental delay, ophthalmological abnormalities and hearing loss. We also performed biochemical studies using patient fibroblasts.ResultsWe identified new compound heterozygous mutations (c.1534G > A, p.Asp512Asn and c.1997G > C, p.Gly666Ala) in ACO2, which encodes aconitase 2, a component of the TCA cycle. In patient fibroblasts, the aconitase activity was reduced to 15% of that of the control, and the aconitase 2 level decreased to 36% of that of the control. As such a decrease in aconitase 2 in patient fibroblasts was partially restored by proteasome inhibition, mutant aconitase 2 was suggested to be relatively unstable and rapidly degraded after being synthesized. In addition, the activity of the father‐derived variant of aconitase 2 (p.Gly666Ala), which had a mutation near the active center, was 55% of that of wild‐type.ConclusionThe marked reduction of aconitase activity in patient fibroblasts was due to the combination of decreased aconitase 2 amount and activity due to mutations. Reduced aconitase activity directly suppresses the TCA cycle, resulting in mitochondrial dysfunction, which may lead to symptoms similar to those observed in mitochondrial diseases.
Genetics and genomic medicine in Sri Lanka
Authors: Sirisena Nirmala D. , Dissanayake Vajira H. W. 
Published: May 2019

AbstractThe completion of the Human Genome Project in 2003 heralded in a new era marked by remarkable advances in biomedical research leading to the establishment of genomics‐based translational medicine mainly in the developed world. However, the development of such advances has been hampered in most parts of the developing world due to scarcity of resources and trained personnel. Genetics and genomic medicine are currently in the process of being integrated into the Sri Lankan health care system. These developments have taken place mainly due to the heightened awareness and increasing demands made by the public for provision of genetic diagnostic and therapeutic services in clinical care. Due to the exorbitant costs incurred in the maintenance of these services and the dearth of adequately trained manpower, only a few centers in the country, mainly in Universities or private sector, are currently engaged in providing these services to the public. This article aims to provide an overview of the genetics and genomic medicine services in Sri Lanka from its early developments to the current state.
n‐3 PUFA Supplementation Alters Retinal Very‐Long‐Chain‐PUFA Levels and Ratios in Diabetic Animal Models
Authors: Gorusupudi Aruna , Chang Fu‐Yen , Nelson Kelly , Hageman Gregory S. , Bernstein Paul S. 
Published: May 2019

ScopeLong‐chain (LC)‐PUFAs act as precursors for the special class of retinal lipids known as very‐long‐chain (VLC)‐PUFAs and the effect of diabetes on retinal VLC‐PUFA levels is unexplored. In order to understand the supplemental effect of omega‐3 (n‐3) LC‐PUFAs on decreasing levels of VLC‐PUFAs due to diabetes, Nile rats, which develop diabetes spontaneously, and Akita mouse, a genetic diabetes model, are chosen.Methods and resultsHuman retinal punches from donors are collected from an eye bank; lipids are extracted and analyzed to study the alterations in VLC‐PUFAs and their omega‐3/omega‐6 (n‐3/n‐6) ratios. Nile rats are fed a high‐fat diet to induce hyperglycemia, and then an n‐3 PUFA‐rich diet is fed to the experimental group for 2 months. Diabetic male Akita mice and WT mice are fed with 5% fish‐oil mixed in with their chow for 2 months to observe the effect of n‐3 PUFAs. Results indicate that VLC‐PUFA levels are lower in human diabetic and retinopathic retinal punches compared to age‐matched controls. With supplementation of n‐3 PUFAs, there is a significant increase in n‐3/n‐6 VLC‐PUFA ratios in both animal models compared to diabetic controls.ConclusionDietary supplementation with n‐3 LC‐PUFAs helps to prevent progression of diabetes and associated retinopathy.
A performance comparison of anthropomorphic model observers for breast cone beam CT images: A single‐slice and multislice study
Authors: Han Minah , Baek Jongduk 
Published: May 2019

PurposeIn this work, we investigate single‐slice and multislice model observers which can predict human observer performance for simulated single‐slice and multislice breast cone beam computed tomography (CBCT) images with a constant internal noise level.MethodsBreast background is generated based on a power spectrum of mammograms, and breast mass is modeled by a spherical signal. Human observer performance is evaluated for detecting 1 and 2 mm signals in different noise structures stemming from different reconstruction filters and image planes in a Feldkamp–Davis–Kress reconstruction. To predict human observer performance, we use single‐slice channelized Hotelling observer (i.e., ssCHO) and multislice CHO (i.e., msCHOa and msCHOb) with dense difference‐of‐Gaussian and Gabor channels. In addition, we use single‐slice nonprewhitening observer with an eye‐filter (i.e., ssNPWE) and multislice NPWE (i.e., msNPWEa and msNPWEb), where ms‐a model estimates the template for each image slice and ms‐b model estimates the template for the central slice. For NPWE, we use the most common eye‐filter with a peak value at a frequency of 4 cyc/deg. In addition, we propose an eye‐filter with a peak value at a frequency of 7 cyc/deg which shows good correlation with human observer performance in single‐slice breast CBCT images. Channel and decision variable internal noise are used for CHO, and decision variable internal noise is used for NPWE. The internal noise level is determined by comparing human and model observer performance for single‐slice images, after which the same level is used for the multislice model observers.ResultsFor single‐slice images, all model observers predict human observer performance well. When the same internal noise level for the single‐slice model observer is used for the multislice model observer, CHO with channel internal noise produces a higher performance than the human observer. In contrast, msCHO and msNPWEb with decision variable internal noise produce a similar performance to the human observer. Especially, ssNPWE and msNPWEb with the proposed eye‐filter predict the human observer performance better than the other model observers for different noise structures.ConclusionsssCHO/ssNPWE and msCHO/msNPWEb with decision variable internal noise can predict human observer performance for single‐slice and multislice images with the same internal noise level. In the presence of breast anatomical background, ssNPWE and msNPWEb with the proposed eye‐filter predict human observer performance better than the other model observers for different noise structures.
CEST MRI monitoring of tumor response to vascular disrupting therapy using high molecular weight dextrans
Authors: Chen Hanwei , Liu Dexiang , Li Yuguo , Xu Xiang , Xu Jiadi , Yadav Nirbhay N. , Zhou Shibin , van Zijl Peter C. M. , Liu Guanshu 
Published: May 2019

PurposeVascular disrupting therapy of cancer has become a promising approach not only to regress tumor growth directly but also to boost the delivery of chemotherapeutics in the tumor. An imaging approach to monitor the changes in tumor vascular permeability, therefore, has important applications for monitoring of vascular disrupting therapies.MethodsMice bearing CT26 subcutaneous colon tumors were injected intravenously with 150 kD dextran (Dex150, diameter, d~ 20 nm, 375 mg/kg), tumor necrosis factor‐alpha (TNF‐α; 1 µg per mouse), or both (n = 3 in each group). The Z‐spectra were acquired before and 2 h after the injection, and the chemical exchange saturation transfer (CEST) signals in the tumors as quantified by asymmetric magnetization transfer ratio (MTRasym) at 1 ppm were compared.ResultsThe results showed a significantly stronger CEST contrast enhancement at 1 ppm (∆MTRasym = 0.042 ± 0.002) in the TNF‐α‐treated tumors than those by Dex150 alone (∆MTRasym = 0.000 ± 0.005, P = 0.0229) or TNF‐α alone (∆MTRasym = 0.002 ± 0.004, P = 0.0264), indicating that the TNF‐α treatment strongly augmented the tumor uptake of 150 kD dextran. The MRI findings were verified by fluorescence imaging and immunofluorescence microscopy.ConclusionsHigh molecular weight dextrans can be used as safe and sensitive CEST MRI contrast agents for monitoring tumor response to vascular disrupting therapy and, potentially, for developing dextran‐based theranostic drug delivery systems.
Comparing questionnaires across cultures: Using Mokken scaling to compare the Italian and English versions of the MOLES index
Authors: Aleo Giuseppe , Bagnasco Annamaria , Watson Roger , Dyson Judith , Cowdell Fiona , Catania Gianluca , Zanini Milko Patrick , Cozzani Emanuele , Parodi Aurora , Sasso Loredana 
Published: May 2019

AbstractAimThe aims of this study were (a) to translate the MOLES index from English to Italian and (ii) to compare the two versions using non‐parametric item response theory.DesignAn online survey was used to gather data.MethodsForward and back translation was used to prepare the Italian version of the MOLES which was then analysed using the non‐parametric item response theory of Mokken scaling.ResultsMokken scales were found in both the English and the Italian versions of the MOLES index. However, the two scales—while the total scale score was not significantly different—showed different properties, and Mokken scaling selected different items from each scale.
Content and impact of articles published by school psychology faculty
Authors: Hulac David M. , Aspiranti Kathleen , Jacobson Madeline , Schneider Maryia , Johnson Natalie 
Published: May 2019

AbstractSchool Psychology faculty members are expected to publish articles in peer‐reviewed journals that impact the fields of education and psychology. Both the content and the impact of the articles school psychologists publish may change across time and differ from other disciplines. The current analysis sought to understand average article impact, content, and research focus, and to describe those articles that have the highest impact factor. All of the articles (n = 3670) published by school psychology faculty between January, 2010 and December, 2015 were collected and examined. Three reviewers were trained over 2 hr to read abstracts and to classify the content of those abstracts. The literature was systematically classified into four categories: assessment, consultation, intervention, and professional issues. The title, keywords, and abstract were used to find the category of best fit for each publication. The majority of articles published fall into the broad category of Professional Issues. The average article is cited 17.68 times in Google Scholar and 4.9 times in Web of Science. These data will be useful to understand publication content trends and identify gaps in research.
Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids
Authors: Chandrasiri Indika , Abebe Daniel G. , Gupta Sudipta , Williams Jon Steven Dal , Rieger William D. , Simms Briana L. , Yaddehige Mahesh Loku , Noh YeRim , Payne Molly E. , Fortenberry Alexander W. , Smith Adam E. , Ilavsky Jan , Grayson Scott M. , Schneider Gerald J. , Watkins Davita L. 
Published: May 2019

ABSTRACTHerein, we present a facile and comprehensive synthetic methodology for the preparation of polyester‐polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA‐PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass ratios of 30:70, 50:50, 70:30, and 90:10 (PLA:PAMAM) were synthesized and analyzed. When placed in aqueous media, the immiscibility of the hydrophilic and hydrophobic segments leads to nanophase‐segregation exhibited as the formation of aggregates (e.g., vesicles, worms, and/or micelles). By employing both stereochemical configurations of PLA, the differentiation in mass ratios of PLA‐PAMAM aided in elucidating the structure–property relationships of the LDBC system and provided a means toward the control of nanoparticle morphology. Transmission electron microscopy and dynamic light scattering afford the size and shape of the nanoparticles with diameters ranging from 10.6 for low mass ratios to 122.4 nm for high mass ratios of PLA‐PAMAM and positive zeta‐potential values between +24.7 mV and +48.2 mV. Furthermore, small‐angle X‐ray scattering (SAXS) studies were employed to obtain more detailed information on the morphological assemblies constructed via direct dissolution. Such insights provide a pathway toward nanomaterials with unique morphologies and tunable properties deemed relevant in the development of next generation biomaterials. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1448–1459
Cobalt Based Nanoparticles Embedded Reduced Graphene Oxide Aerogel for Hydrogen Evolution Electrocatalyst
Authors: Koo Sung Hwan , Li Dong Jun , Yun Taeyeong , Choi Dong Sung , Lee Kyung Eun , Lee Gil Yong , Oh Youngtak , Lim Joonwon , Padmajan Sasikala Suchithra , Lee Ho Jin , Kim In Ho , Jung Hong Ju , Jain Rishabh , Kim Sang Ouk 
Published: May 2019

AbstractEfficient water electrolysis catalyst is highly demanded for the production of hydrogen as a sustainable energy fuel. It is reported that cobalt derived nanoparticle (CoS2, CoP, CoS|P) decorated reduced graphene oxide (rGO) composite aerogel catalysts for highly active and reliable hydrogen evolution reaction electrocatalysts. 7 nm level cobalt derived nanoparticles are synthesized over graphene aerogel surfaces with excellent surface coverage and maximal expose of active sites. CoS|P/rGO hybrid aerogel composites show an excellent catalytic activity with overpotential of ≈169 mV at a current density of ≈10 mA cm−2. Accordingly, efficient charge transfer is attained with Tafel slope of ≈52 mV dec−1 and a charge transfer resistance (Rct) of ≈12 Ω. This work suggests a viable route toward ultrasmall, uniform nanoparticles decorated graphene surfaces with well‐controlled chemical compositions, which can be generally useful for various applications commonly requiring large exposure of active surface area as well as robust interparticle charger transfer.
Two‐sample homogeneity testing: A procedure based on comparing distributions of interpoint distances
Authors: Montero‐Manso Pablo , Vilar José A. 
Published: May 2019

AbstractA new test statistic using interpoint distances is proposed to address the two‐sample problem for multivariate populations. The test statistic compares univariate distributions of within and between samples pairwise distances using a Cramér‐von Mises‐type statistic. The critical values are approximated by means of a permutation procedure and the regularity conditions required to ensure the consistency of the test are established. Unlike other two‐sample procedures, our approach compares the whole distributions of interpoint distances instead of just a few moments, thus obtaining a higher capability to detect differences in their shape or in other moments. An extensive simulation study and experiments with real data sets considered in related papers show a satisfactory performance of the proposed test under a range of alternative distributions. Compared to other two‐sample tests based on interpoint distances, the experiments reveal a more robust behavior in a high‐dimensional setting, being one of the most powerful tests under both location and scales changes.
A Straightforward Synthesis of Tribromomethyl Carbinols from Aldehydes and Bromoform with Potassium Hydroxide as the Catalyst
Authors: Hasimujiang Balati , Cheng Zhao , Wusiman Abudureheman , Yang Ying , Abudu Rexit Abulikemu 
Published: May 2019

AbstractKOH was used as the catalyst for an efficient synthesis of tribromoethyl carbinols from aldehydes and bromoform. The new synthesis method has many advantages, such as the low price of the raw materials and catalyst, the wide range of substrates such as, aromatic, aliphatic and heterocyclic aldehydes. It's worth mentioning that the reaction could be scaled up to grams in excellent yield (99%), in the presence of 10 mol% KOH.