bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes and Predictors of Revision Anterior Cruciate Ligament Reconstruction: An Evaluation of the Norwegian Knee Ligament Registry
Authors: Vap Alexander R. , LaPrade Robert F. , Engebretsen Lars 
Published: March 2018

Objectives: The Norwegian Ligament Registry (NKLR) provides an opportunity for quality surveillance and research. Intraoperative findings and outcome after revision anterior cruciate ligament reconstruction (RACLR) is not as well studied as after primary ACL reconstruction. There were two objectives of this study. First, to evaluate the Norwegian Knee Ligament Registry (NKLR) for the occurrence, failure rate, graft choice, patient demographic profile (gender, age, body mass index), sport at time of injury and associated pathology (cartilage injuries, meniscal tears, other ligament injuries) for revision anterior cruciate ligament reconstructions (RACLR). Second, to match compare RACLR patients to primary ACL reconstructions in order to define possible predictors for those patients who will require RACLR. Methods: All patients identified in the NKLR from June 2004 until September 2016 that did not undergo cartilage restoration, meniscal transplant nor had a documented fracture at the primary reconstruction were included in the study. Revision rates at 1, 2 and 5 years were estimated with Kaplan-Meier analysis, and the estimated risk of RACLR based upon demographic and associated pathology was estimated with Cox regression analysis. Results: 784 patients with an average age of 25.6 years (25.0-26.3) met the inclusion and exclusion criteria with 53.1% being male. 62.1% of revisions were performed with bone patellar bone (BPTB) autograft while 23% used hamstring autograft. Associated injuries of the menisci, cartilage, and other ligaments and the sport at the time of injury are listed (Table 1). 12.9% of RACLR patients went on to have a Re-revision ACLR at 5 years postop (Figure 1). Match comparisons of primary ACLR patients with RACLR demonstrated no significant difference in occurrence based upon age (<20, 20-30, and >30 years), graft choice (BPTB, Hamstring, Allograft, Bone Quadriceps Tendon (BQT)), cartilage injury (No injury, ICRS 1-2, ICRS 3-4), meniscal Injury, associated ligament injury, sport at time of injury or Body Mass Index (BMI). Conclusion: Based upon review of a large ligament reconstruction registry, one can expect that less than 13% of patients undergo a Re-revision ALCR following failure of a RALCR at 5 years. Match comparison of primary ACLR versus RACLR demonstrated no significant predictor of RACLR based upon age, graft choice, cartilage injury, meniscal injury, associated ligament injury, sport or BMI.
Phase II Study of Crizotinib in East Asian Patients With ROS1-Positive Advanced Non–Small-Cell Lung Cancer
Authors: Wu Yi-Long , Yang James Chih-Hsin , Kim Dong-Wan , Lu Shun , Zhou Jianying , Seto Takashi , Yang Jin-Ji , Yamamoto Noboru , Ahn Myung-Ju , Takahashi Toshiaki , Yamanaka Takeharu , Kemner Allison , Roychowdhury Debasish , Paolini Jolanda , Usari Tiziana , Wilner Keith D. , Goto Koichi 
Published: March 2018

Purpose Approximately 1% to 2% of non–small-cell lung cancers (NSCLCs) harbor a c-ros oncogene 1 ( ROS1) rearrangement. Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), ROS1, and MET, has shown marked antitumor activity in a small expansion cohort of patients with ROS1-positive advanced NSCLC from an ongoing phase I study. We assessed the efficacy and safety of crizotinib in the largest cohort of patients with ROS1-positive advanced NSCLC. Patients and Methods This phase II, open-label, single-arm trial enrolled East Asian patients with ROS1-positive (assessed through validated AmoyDx assay [Amoy Diagnostics, Xiamen, China] at three regional laboratories) advanced NSCLC who had received three or fewer lines of prior systemic therapies. Patients were to receive oral crizotinib at a starting dose of 250 mg twice daily and continued treatment until Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1–defined progression (by independent radiology review [IRR]), unacceptable toxicity, or withdrawal of consent. The primary end point was objective response rate (ORR) by IRR. Results In the efficacy and safety analyses, 127 patients were included, with 49.6% still receiving treatment at data cutoff. ORR by IRR was 71.7% (95% CI, 63.0% to 79.3%), with 17 complete responses and 74 partial responses. ORRs were similar irrespective of the number of prior lines of therapy, and responses were durable (median duration of response, 19.7 months; 95% CI, 14.1 months to not reached). Median progression-free survival by IRR was 15.9 months (95% CI, 12.9 to 24.0 months). No new safety signals associated with crizotinib were reported. Conclusion This study demonstrated clinically meaningful benefit and durable responses with crizotinib in East Asian patients with ROS1-positive advanced NSCLC. Crizotinib was generally well tolerated, with a safety profile consistent with previous reports.
Cord Metabolic Profiles in Obese Pregnant Women: Insights Into Offspring Growth and Body Composition
Authors: Patel Nashita , Hellmuth Christian , Uhl Olaf , Godfrey Keith , Briley Annette , Welsh Paul , Pasupathy Dharmintra , Seed Paul T , Koletzko Berthold , Poston Lucilla ,   UPBEAT Consortium
Published: March 2018

AbstractContextOffspring exposed in utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown.ObjectiveTo assess the effect of an antenatal lifestyle intervention in obese women on the offspring’s cord blood metabolic profile and to examine associations of the cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months.DesignRandomized controlled trial and cohort study.SettingThe UK Pregnancies Better Eating and Activity Trial.ParticipantsThree hundred forty-four mother-offspring pairs.InterventionAntenatal behavioral lifestyle (diet and physical activity) intervention.Main Outcome MeasuresTargeted cord blood metabolic profile, including candidate hormone and metabolomic analyses.ResultsThe lifestyle intervention was not associated with change in the cord blood metabolic profile. Higher maternal glycemia, specifically fasting glucose at 28 weeks gestation, had a linear association with higher cord blood concentrations of lysophosphatidylcholines (LPCs) 16.1 (β = 0.65; 95% confidence interval: 0.03 to 0.10) and 18.1 (0.52; 0.02 to 0.80), independent of the lifestyle intervention. A principal component of cord blood phosphatidylcholines and LPCs was associated with infant z scores of birth weight (0.04; 0.02 to 0.07) and weight at age 6 months (0.05; 0.00 to 0.10). Cord blood insulin growth factor (IGF)-1 and adiponectin concentrations were positively associated with infant weight z score at birth and at 6 months.ConclusionsConcentrations of LPCs and IGF-1 in cord blood are related to infant weight. These findings support the hypothesis that susceptibility to childhood obesity may be programmed in utero, but further investigation is required to establish whether these associations are causally related.
Pathways to Profits: The Impact of Marketing vs. Finance Skills on Business Performance
Authors: Anderson Stephen J. , Chandy Rajesh , Zia Bilal 
Published: March 2018

This paper examines the impact of improvements in marketing skills relative to finance skills among small-scale entrepreneurs. It addresses three important questions: (1) What is the impact of marketing or finance skills on business profits? (2) How do improvements in marketing and finance skills respectively affect different business outcomes? (3) When are increases in marketing relative to finance skills more beneficial? Through a randomized control study of 852 firms in South Africa, the analysis finds significant improvements in profitability from both types of business skills training. However, the pathways to achieve these gains differ substantially between the two groups. The marketing group achieves greater profits by adopting a growth focus on higher sales, greater investments in stock and materials, and hiring more employees. The finance group achieves similar profit gains but through an efficiency focus on lower costs. Both groups show significantly higher adoption of business practices related to their respective training program. Consistent with a growth focus, marketing/sales skills are significantly more beneficial to businesses run by entrepreneurs with ex ante less exposure to different market contexts. In contrast and in line with an efficiency focus, it is the more established businesses that benefit significantly more from finance/accounting skills. This paper was accepted by Eric Anderson, marketing. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2920 .
Tick-borne encephalitis: What is it and how can it be prevented?
Authors: Graham Sharon 
Published: March 2018

Tick-borne encephalitis is a potentially life-changing disease. Sharon Graham explains the transmission, risk and prevention of the disease in travellers Tick-borne encephalitis is caused by a Flavivirus transmitted by the bite of the Ixodes tick or through consumption of unpasteurised dairy products. Tick-borne encephalitis is endemic across a large area of Europe and Asia. Clinical presentation can vary from mild, non-specific, febrile illness, to life-threatening illness with the potential for long-term sequelae affecting the central nervous system. This article will outline the transmission, risk and prevention of tick-borne encephalitis with details of the vaccines available in UK.
Preceptorship in primary care: Why is it needed?
Authors: Skelly Mia 
Published: March 2018

Preceptorship is essential to the development of newly qualified nurses, as well as those moving into general practice from other areas of nursing. Mia Skelly discusses the need for preceptorship in primary care Preceptorship programmes have been recognised as fundamental to the development of a newly qualified nurse into a competent and confident practitioner. All nurses who are new to general practice should be equipped for the role by accessing a standardised preceptorship programme. In September 2017, the CapitalNurse Programme launched its Pan-London Preceptorship Framework to standardise the preceptorship programmes being offered across London. If we are to attract, grow and nurture the next generation of newly qualified nurses into primary care, then best practice programmes need to be developed.
Do dog owners recognise behavioural indicators of canine cognitive dysfunction and can environmental enrichment techniques slow its progression?
Authors: Coupland Sarah , Reynolds Helen 
Published: March 2018

Background: Veterinary professionals have seen a rise in geriatric patients suffering from canine cognitive dysfunction (CCD). Previous literature has supported the use of environmental enrichment therapies which have been considered to reduce the progression of cognitive decline in CCD. However, CCD is commonly undiagnosed within the companion dog population. Aim: To determine whether owners of older dogs are able to notice behavioural changes, and in addition, explore knowledge around the term environmental enrichment which may help owners slow the progression of CCD through further education. Method: The study involved quantitative research using a questionnaire with 11 questions. Data were subsequently statistically analysed. Of the participants 16 worked within a veterinary practice, 52 were customers visiting a pet shop and 39 respondents formed a web survey group predominantly of veterinary professionals. Results: Owners of geriatric dogs working within a veterinary-related field were more likely to notice behavioural changes possibly associated with CCD compared with the average owner of a geriatric dog, and were also more likely to understand the term environmental enrichment. Conclusion: This study informs the veterinary field that improved education strategies implemented within nurse clinics may help pet owners recognise behavioural indicators of CCD, and treatment recommendations may assist in slowing the progression of CCD in geriatric dogs.
The philosophy of the Ramones
Authors: Dixon Wheeler Winston 
Published: March 2018

Abstract
This article traces the history and influence of The Ramones, an American rock & roll band that founded the ‘punk rock’ movement, which then spread to England and such bands as The Sex Pistols, The Clash, along with many other similar groups. Although they never achieved mainstream success during their more than twenty year career, The Ramones are now are considered by many to be one of the most important pop music groups of the later twenty-century, transforming 1970s rock & with a stripped-down style that combined speed, simplicity, and a confrontational approach to performance. Though all the members of the group have died, their music has become part of the fabric of American pop culture, inspiring such contemporary bands as Green Day, Nirvana and Metallica.
Customer participation in the creation and implementation of the service for internet banking
Authors: . Ronny 
Published: March 2018

This study aims to answer two important issues such as what value of internet banking services that is prioritized by the bank in the implementation of internet banking, and how the bank tries to involve the customers in creating and implementing the value of internet banking services. This study conducted by an In-depth interview on 3 informant bank officials from three banks in Indonesia who have authority to handle internet banking services. The analysis was based on the interview result. The results shows that banks expect customers to participate in 5 aspects of internet banking security, feedback in form of input and assessment of internet banking, customer support on the use of adequate technology, customer knowledge and skills about information technology, and customer involvement in new feature development trials of Â Internet banking. Such customer participation leads to service value creation such as security, convenience, benefits, emotional, and communication.
Spa and Wellness Tourism in Slovakia (A Geographical Analysis)
Authors: Kasagranda Anton , Gurňák Daniel 
Published: March 2018

Abstract
Spa industry is presently an inherent part of Slovak tourism. For this reason, it has become a major interest of scientific and professional literature (economics, management, sociology, or geography). The main topic of this paper is the evaluation of tourism in Slovakia through a geographic analysis. This paper briefly evaluates the development and the importance of spa, spa tourism and wellness and their main research areas and issues. Furthermore, the primary sources of tourism development, the overview of spa tourism and the wellness resorts, the accommodation establishments and the visitation rate are evaluated as well. In conclusion, functional and spatial typification of spa tourism and wellness in Slovakia is presented. The structure of the paper is designed to be appropriate for a comparison with V4 countries.
Lipedema: friend and foe
Authors: Torre Yanira Sanchez-De la , Wadeea Rita , Rosas Victoria , Herbst Karen L. 
Published: March 2018

Abstract

Background
Lipedema is a chronic disorder presenting in women during puberty or other times of hormonal change such as childbirth or menopause, characterized by symmetric enlargement of nodular, painful subcutaneous adipose tissue (fat) in the limbs, sparing the hands, feet and trunk. Healthcare providers underdiagnose or misdiagnose lipedema as obesity or lymphedema.

Materials and methods
The benefits (friend) and negative aspects (foe) of lipedema were collected from published literature, discussions with women with lipedema, and institutional review board approved evaluation of medical charts of 46 women with lipedema.

Results
Lipedema is a foe because lifestyle change does not reduce lipedema fat, the fat is painful, can become obese, causes gait and joint abnormalities, fatigue, lymphedema and psychosocial distress. Hypermobility associated with lipedema can exacerbate joint disease and aortic disease. In contrast, lipedema fat can be a friend as it is associated with relative reductions in obesity-related metabolic dysfunction. In new data collected, lipedema was associated with a low risk of diabetes (2%), dyslipidemia (11.7%) and hypertension (13%) despite an obese average body mass index (BMI) of 35.3 ± 1.7 kg/m2.

Conclusion
Lipedema is a painful psychologically distressing fat disorder, more foe than friend especially due to associated obesity and lymphedema. More controlled studies are needed to study the mechanisms and treatments for lipedema.
Antimicrobial properties of terrestrial snail and slug mucus
Authors: Cilia Giovanni , Fratini Filippo 
Published: March 2018

Abstract
Snail and slug mucus is a viscous-elastic substance secreted by specific glands with adhesive and lubricants properties that allows them to adhere tenaciously to many different surfaces. It has been used since ancient times for care and human health and it is still very important in traditional and folkloristic medicine. Recently, mucus from snail and slugs and its protein and components have been subjected to some investigations on their antibacterial, antiviral and antifungal activity due to extensive traditional uses and for a future application in medicine. Antimicrobial activities of crude mucus, and its components, against different microorganism have been reported, showing antimicrobial activities that lead their potential employment in several fields as natural additives. The purpose of this Review is to summarize the results of antimicrobial studies of snail and slug mucus and its compounds from the first scientific applications to the isolation of the single components in order to better understand its application and propose an employment in future studies as a natural antimicrobial agent.
Periodization in College Soccer
Authors: Favero Terence G. , White John 
Published: March 2018

ABSTRACT
PERIODIZATION OPTIMIZES TRAINING RESPONSES TO IMPROVE PERFORMANCE. COLLEGE SOCCER PRESENTS A UNIQUE CHALLENGE TO PERIODIZED APPROACHES BECAUSE OF A SHORT PRESEASON AND CONDENSED MATCH SCHEDULE. ACADEMIC CHALLENGES OF CLASS TIME AND INTENSIVE EXAMINATION SCHEDULES IMPACT ATHLETE'S SLEEP AND INTERFERE WITH FULL RECOVERY OFTEN LEAVING ATHLETES FATIGUED AND TIRED DURING AND AT THE END OF THE SEASON. THIS ARTICLE OUTLINES A MODEL SYSTEM TO ORGANIZE PERIODIZED TRAINING OVER AN ENTIRE YEAR, INCLUDING SUMMER TRAINING, PRESEASON, AND THE COMPETITIVE COLLEGIATE SEASON. PRACTICAL SUGGESTIONS ARE OFFERED TO ADDRESS ACADEMIC AND SEASONAL CHALLENGES WHILE PREVENTING INJURY, AVOIDING BURNOUT, AND LATE SEASON PERFORMANCE DECLINES.
Anxiety and Mood Disorder in Children With Autism Spectrum Disorder and ADHD
Authors: Gordon-Lipkin Eliza , Marvin Alison R. , Law J. Kiely , Lipkin Paul H. 
Published: March 2018

OBJECTIVES:Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. Understanding the endophenotype of children with both ASD and ADHD may impact clinical management. In this study, we compare the comorbidity of anxiety and mood disorders in children with ASD, with and without ADHD.METHODS:We performed a cross-sectional study of children with ASD who were enrolled in the Interactive Autism Network, an Internet-mediated, parent-report, autism research registry. Children ages 6 to 17 years with a parent-reported, professional, and questionnaire-verified diagnosis of ASD were included. Data were extracted regarding parent-reported diagnosis and/or treatment of ADHD, anxiety disorder, and mood disorder. ASD severity was measured by using Social Responsiveness Scale total raw scores.RESULTS:There were 3319 children who met inclusion criteria. Of these, 1503 (45.3%) had ADHD. Comorbid ADHD increased with age (P &lt; .001) and was associated with increased ASD severity (P &lt; .001). A generalized linear model revealed that children with ASD and ADHD had an increased risk of anxiety disorder (adjusted relative risk 2.20; 95% confidence interval 1.97–2.46) and mood disorder (adjusted relative risk 2.72; 95% confidence interval 2.28–3.24) compared with children with ASD alone. Increasing age was the most significant contributor to the presence of anxiety disorder and mood disorder.CONCLUSIONS:Co-occurrence of ADHD is common in children with ASD. Children with both ASD and ADHD have an increased risk of anxiety and mood disorders. Physicians who care for children with ASD should be aware of the coexistence of these treatable conditions.
Desenvolvimento rural e agricultura familiar: um estudo do Projeto de Assentamento Dirigido Humaitá - Porto Acre (AC)
Authors: Maciel Raimundo Cláudio Gomes , Mariano Reginaldo Silva , Cavalcante Filho Pedro Gilberto 
Published: March 2018

Resumo
Em uma tentativa de minimizar os efeitos negativos da questão agrária o Governo vem implantando ferramentas que possam solucionar o problema agrário, como o Estatuto da Terra e a criação do Instituto Nacional de Colonização e Reforma Agrária-INCRA. Neste processo foram instituídos mecanismos do modelo da reforma agrária, onde se encontram 20 tipos de assentamentos como os Projetos de Assentamentos Dirigidos-PADs. Este trabalho tem como objetivo avaliar o Projeto de Assentamento Dirigido Humaitá localizado no município de Porto Acre - AC. Para isso, se utiliza uma análise da dinâmica do Índice de Desenvolvimento Familiar Rural-IDF-R no período de 2005/2006 e 2012/2013. Esse índice permite encontrar as condições de vida do produtor familiar rural, abordando dimensões de seu cotidiano e comparando ambos os períodos. Os resultados indicam que o tão almejado desenvolvimento rural não foi alcançado pelas unidades de produção familiar do Humaitá.
OKUL ÖNCESİ DÖNEMDE HAZZI GECİKTİRME VE YARATICILIK ARASINDAKİ İLİŞKİDE BİLİŞSEL ESNEKLİĞİN ARACI ROL
Authors: HASÇUHADAR Bilgesu , COŞKUN Hamit 
Published: March 2018

Çalışmanın amacı, okul öncesi dönemdeki çocukların
yaratıcılıkları ve hazzı geciktirme becerileri arasındaki ilişkiyi ve bu
ilişkide bilişsel esneklik ve kararlılığın aracı rolünü incelemektir.
Araştırmanın çalışma grubu Bolu’daki okul öncesi kurumlara devam eden 4-5
yaşlarında 83’ü erkek, 87’si kız 170 çocuktan oluşmaktadır. Araştırmada
çocukların hazzı geciktirme becerilerini ölçmek amacıyla Mischel ve Ebbesen
(1970) tarafından geliştirilen ve arzu duyulan bir ödül için çocuğun
beklemesini gerektiren yöntem yardımıyla ölçülmüştür. Yaratıcılık ölçümü için
ise çocuktan bir obje için farklı kullanımlar üretmesi yardımlı ve yardımsız
görev ile değerlendirilmiştir. Üretilen kullanımların kategorilere ayrılması
yoluyla da esneklik ve kararlılık puanları hesaplanmıştır. Araştırmanın
bulguları, çocukların yaratıcılıkları, esneklikleri, kararlılıkları ve hazzı
erteleme sürelerinin birbiriyle anlamlı şekilde ilişkili olduğunu
görstermektedir. Ayrıca çocukların yaratıcılıkları ve hazzı geciktirme
becerileri arasındaki ilişkide esnekliğin aracı değişken olduğu görülmüştür.
Öte yandan bu ilişkide kararlılığın aracı rol oynamadığı görülmektedir.
Bulgular literatür çerçevesinde tartışılmıştır.&nbsp;