bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Using a Digital Case Management Application to Expand the Patient Navigator System at Bugando Medical Centre
Authors: Maiarana Jimmy , Zullig Leah , Vasudevan Lavanya , Masalu Nestory , Schroeder Kristin 
Published: March 2018

Abstract 36 Purpose Each year, more than 200,000 children globally are diagnosed with cancer, more than 80% of which occurs in low- to middle-income countries. Pediatric cancer survival rates in low- to middle-income countries are 5% to 25% compared with 80% in high-income countries, with treatment abandonment accounting for one third of the survival gap. A mobile case management system can improve patient communication and reduce treatment abandonment. The current proposal evaluated the feasibility and acceptability of a mobile phone–based case management system at Bugando Medical Centre (BMC) in Mwanza, Tanzania. Methods We surveyed 40 families of children with cancer who attended BMC and 10 pediatric oncology providers at BMC to assess mobile phone ownership, use patterns, communication preferences (eg, voice v text messaging), and the advantages and disadvantages of a mobile case management system. Results In all, 85% of families owned a mobile phone and 100% of providers owned smart phones. Of families, 98% wanted to communicate with a health care provider regarding treatment support using a mobile phone, 92% wanted to receive laboratory results via mobile phone, 95% wanted to receive reminders of upcoming appointments, and 88% wanted to receive educational information on cancer via mobile phone. Of providers, 100% thought that it would be useful to use a mobile phone to communicate with patients, share laboratory results, and view standardized pediatric treatment protocols and checklists. Conclusion Most families of pediatric patients with cancer at BMC use mobile phones, with high interest in using mobile technology to communicate with providers. This increases the likelihood of success for a mobile case management platform that is aimed at reducing the abandonment of care among pediatric patients with cancer. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.
Using a Mobile Health Application for Data Collection in Esophageal Cancer Case-Control Studies in Africa
Authors: Pritchett Natalie , Murphy Gwen , Middleton Daniel , McCormack Valerie 
Published: March 2018

Abstract 38 Purpose Partners in the African Esophageal Cancer Consortium have recently begun several new case-control studies. Building on prior breast cancer research in the region using a mobile application programmed by Mobenzi, a South African–based mobile health company, we decided to leverage the technology to support the success of this combined effort. The aim of the current study was to coordinate research in multiple settings to evaluate known and new risk factors and their contributions to the African esophageal squamous cell carcinoma burden, as well as to use the mobile health platform with the same questions across sites when possible, but allow site-specific questions when needed to optimize data collection efficiency and accuracy. Methods Substantial effort was dedicated to harmonizing esophageal squamous cell carcinoma questionnaires used in high-risk areas around the world to capture a broad range of putative risk factors. Priority was placed on established or probable carcinogens that have been previously identified, as well as tailoring the questionnaires for each site to explore new exposures that are unique to these settings. Skip patterns were programmed into the application to ensure proper survey application. Informed consent documents, biospecimens, and pathology reports can be labeled with QR codes and scanned into the application for documentation and tracking. Results The application is currently in use at four consortium-led case-control study sites in Moshi, Tanzania; Bomet, Kenya; Lilongwe, Malawi; and Blantyre, Malawi. After downloading the application to a study tablet, data collection can begin and then be uploaded to the shared, secure mobile health database immediately or whenever internet access allows. Conclusion All study sites are now collecting data using this mobile health platform. The application will increase efficiency, eliminate transcription mistakes, and allow real-time quality control and supervision of field activities from any location worldwide. Unified data entry on mobile devices will also allow us to quickly pool data and analyze similarities and differences across sites. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.
m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics
Authors: Consolato Francesco , Maltecca Francesca , Tulli Susanna , Sambri Irene , Casari Giorgio 
Published: March 2018

ABSTRACT
The proteolytic processing of dynamin-like GTPase OPA1, mediated by the activity of both YME1L1 [intermembrane (i)-AAA protease complex] and OMA1, is a crucial step in the regulation of mitochondrial dynamics. OMA1 is a zinc metallopeptidase of the inner mitochondrial membrane that undergoes pre-activating proteolytic and auto-proteolytic cleavage after mitochondrial import. Here, we identify AFG3L2 [matrix (m)-AAA complex] as the major protease mediating this event, which acts by maturing the 60 kDa pre-pro-OMA1 to the 40 kDa pro-OMA1 form by severing the N-terminal portion without recognizing a specific consensus sequence. Therefore, m-AAA and i-AAA complexes coordinately regulate OMA1 processing and turnover, and consequently control which OPA1 isoforms are present, thus adding new information on the molecular mechanisms of mitochondrial dynamics and neurodegenerative diseases affected by these phenomena.
This article has an associated First Person interview with the first author of the paper.
Kompressionstherapie nach operativer Varizensanierung
Authors: Cucuruz B. , Bourdy M. , Korte A. , Noppeney J. , Noppeney T. 
Published: March 2018

ZusammenfassungDie Kompressionstherapie ist bis heute eine Alternative zur operativen Varizensanierung und der Goldstandard in der Therapie chronisch venöser Insuffizienz. Umstritten ist die Frage der postoperativen Kompressionstherapie. Ziel dieser Arbeit ist es einen Überblick der aktuellen Literatur bezüglich der postoperativen Kompressionstherapie zu bieten.Es wurde eine Literaturrecherche in Medline, pubmed und Embase mit dem Thema der operative Varizensanierung durchgeführt. Aus den Arbeiten wurde die jeweils verwendete postoperative Kompressionstherapie erfasst.Es wurden 182 Studien erfasst, davon jedoch nur 7 randomisierte Studien Die Kompressionstherapie variiert von keiner bis zu 6 Wochen langen Kompression. Es wurde immer eine elastische Kompression verwendet, zumeist Kompressionsstrümpfe.Die postoperative Kompressionstherapie nach operativer Varizensanierung wird unabhängig der verwendeten operativen Methode empfohlen. Aufgrund der eingeschränkten Datenlage gibt es keine Empfehlung zur Dauer der postoperativen Kompression oder eine empfohlene Kompressionsstrumpflänge.
Polymeric clips are a quicker and cheaper alternative to endoscopic ligatures for securing the appendiceal stump during laparoscopic appendicectomy
Authors: Wilson MSJ , Maniam P , Ibrahim A , Makaram N , Knight SR , Patil P 
Published: March 2018

Introduction The use of polymeric clips in securing the appendiceal stump has been increasingly reported as a viable alternative to current methods in emergency laparoscopic appendicectomy. We evaluated the operative outcomes following the use of polymeric clips versus endoscopic ligatures. The primary endpoint was operative time, with secondary outcomes including complications, inpatient stay, and cost analysis. Materials and methods Operative records were retrospectively analysed to identify patients undergoing laparoscopic appendicectomy between January 2014 and June 2015. Data collected included age, gender, body mass index, duration of surgery, length of hospital stay, antibiotic use, preoperative haematological and biochemical parameters, 30-day readmission rate and complications. Results A total of 125 patients were included within the study, with 78 within the endoloop group and 47 in the polymeric clip group. There were no differences in age, gender, body mass index, hospital stay, antibiotic use, 30-day readmission rates or postoperative complications. Operative time was significantly reduced in the polymeric clip group (59 vs. 68 minutes, P = 0.00751). The use of polymeric clips cost £21 compared with £49 for endoloops per operation, which rose to £70 if both clips and endoloops were used during the procedure. Discussion Polymeric clips are a safe, viable and economical method for securing the appendiceal stump during laparoscopic appendicectomy. The clinical significance of nine minutes of reduced operating time in the polymeric clip cohort warrants further study with an adequately powered randomised controlled trial.
Biodynamic excisional skin tension lines for surgical excisions: untangling the science
Authors: Paul SP 
Published: March 2018

Objective There remains confusion between Langer’s lines and wrinkle lines with respect to the optimal orientation of elliptical excisions on the trunk. This study sought to determine the directions of wound closure that would result in least wound tension after skin lesion excisions. Materials and methods Some 1181 consecutive skin lesion excisions were investigated (age range 13–95 years, median 64 years) using a tensiometer to determine directions of least wound tension. These lines were mapped. Skin tension measurements were taken during the procedure and analysed. The clear majority of excisions were for skin cancer and the others were for cysts or dysplastic naevi. Lesions such as lipomas, which entail incisional rather than excisional surgery (i.e. where overlying skin was not excised) were excluded. All lesions were cut out in a circular fashion following tension measurements. Closure was undertaken in the direction of least tension (biodynamic excisional skin tension line) and this was illustrated. This process was repeated in all cases where body site and direction of closure was mapped. Statistical analyses were undertaken on a series on the scalp and lower limb. Results Biodynamic excisional skin tension lines have a clear directional preference: scalp–coronal direction, limbs-–vertical orientation of ellipses and trunk – mostly horizontal except oblique at the shoulder and scapular regions. Discussion Skin cancer excisions often end up with poor cosmetic results, owing to inconsistency in identifying the correct excisional wound closure lines. This has not been helped by the (hitherto) lack of large in vivo biomechanical studies, and because incisional lines and excisional lines have not been considered separately in surgical practice. Orientating ellipses or wound closures using biodynamic excisional skin tension lines offers a guide to reducing wound tension and minimising wound complications or scarring after cutaneous surgery.
Postoperative monitoring of the free jejunal flap: use of colour duplex and systematic review of available techniques
Authors: Cuthbert R , Deutsch C , Roy A , Stimpson P , Patel H 
Published: March 2018

Introduction The free jejunal flap represents the gold standard for circumferential defects in upper digestive tract reconstruction. It is a technically demanding procedure with significant failure rates. Unrecognised failure leads to flap necrosis and potentially fatal sequelae, including sepsis and carotid artery bleed. Despite these catastrophic consequences, however, there remains no consensus on an optimum method for postoperative flap monitoring. Our unit has pioneered the use of external colour duplex ultrasound to monitor flap vascularity. We describe this technique and systematically review other published monitoring systems. Materials and methods A patient underwent oesophageal reconstruction using a jejunal free flap. Monitoring commenced immediately via external application of a colour duplex probe over the flap’s vascular pedicle to facilitate flow volume assessment. Further bi-daily assessments were successfully used to monitor the postoperative viability of the flap. The systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Six alternative monitoring techniques were identified: exteriorised jejunal segment, implantable Doppler probe, watch window, microdialysis, microendoscopy and reflectance photoplethysmography. Discussion Exteriorised jejunal segment and implantable Doppler probe are most commonly described, yet both are associated with high false positive rates, which is particularly significant in a patient demographic facing increased general anaesthetic risk. Most other techniques remain experimental. External colour Doppler ultrasound provides the surgeon with immediate reassurance following the reconstruction, requires minimal training to use, and eliminates the need for revisional procedures. Conclusion Our initial experience suggests that external colour Doppler ultrasound has exciting potential as an efficient and noninvasive technique for monitoring the free jejunal flap.
Haicai: Sequência Didática na perspectiva do Letramento Literário
Authors: Dantas Walmeria Oliveira , El Fahl Alana De Oliveira Freitas 
Published: March 2018

Este artigo traz um recorte da dissertação de mestrado Flash poético: uma experiência de leitura e produção de haicais e fotografias na perspectiva do letramento literário, trata-se de uma pesquisa de base qualitativa com foco na pesquisa-ação, que apresenta uma proposta de intervenção baseada na metodologia de sequência didática aplicada à leitura e a escrita de haicais, inspirados em fotografias autorais. Com o objetivo de contribuir para o aumento dos níveis de letramento literário de uma turma de alunos do sétimo ano do ensino fundamental. A pesquisa foi realizada no Colégio Estadual José Ferreira Pinto, na cidade de Feira de Santana/BA. Neste recorte apresentamos a Sequência Didática e parte do material didático utilizado durante a intervenção. Os resultados obtidos durante o estudo evidenciaram a importância da utilização de materiais didáticos que dialoguem com a realidade e as experiências de vida dos alunos, possibilitando-os a aprendizagem na perspectiva do Letramento Literário. Palavras chave: Letramento literário. Haicai. Sequência Didática.
Telemedicine: is it really worth it? A perspective from evidence and experience
Authors: Freed James , Lowe Charles , Flodgren Gerd , Binks Rachel , Doughty Kevin , Kolsi Jyrki 
Published: March 2018

BackgroundThis paper summarises a series of presentations on telemedicine given at a UK eHealth Week conference session in 2016. The formal evidence base for telemedicine is equivocal, but practical experience suggests that implementations of technology that support telemedicine initiatives can result in improved patient outcomes, better patient and carer experience and reduced expenditure.ObjectiveTo answer the questions ‘Is an investment in telemedicine worth it’? and ‘How do I make a telemedicine implementation work’?MethodsSummary of systematic review evidence and an illustrative case study. Discussion of implications for industry and policy.ResultsRealisation of telemedicine benefits is much less to do with the technology itself and much more around the context of the implementing organisation and its ability to implement.ConclusionWe recommend that local organisations consider deployment of telemedicine initiatives but with a greater awareness of the growing body of implementation best practice. We also recommend, for the National Health Service, that the centre takes a greater role in the collation and dissemination of best practice to support successful implementations of telemedicine and other health informatics initiatives.
Antioxidant Capacity Comparison of Ethanolic Extract of Soursop (Annona muricata Linn.) Leaves and Seeds as Cancer Prevention Candidate
Authors: Widyastuti Dyah Ayu , Rahayu Praptining 
Published: March 2018

<em>Annona muricata</em> Linn. (soursop) is one of tropical plants which have relatively complete chemical compounds. It has flavonoid, tannin, phytosterol, alkaloid, etc. The high antioxidant compound in soursop is believed as cancer prevention so the cancer threat in the world can be minimized. The antioxidant compound in soursop can be found not only in its fruit, but also in other parts like leaves, seeds, etc. Based on that potency, this study aimed to compare antioxidant capacity of soursop leaves and seeds, also to study about the utilization of soursop parts which is usually not used. This research began with maceration to extract leaves and seeds with 96% ethanol. Ethanolic extract of soursop leaves and seeds were then tested for antioxidant capacity with DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The result showed that antioxidant capacity of soursop leaves and seeds are 85,66875% and 39,0166, respectively. The antioxidant capacity of leaves is higher than seeds due to seed’s extraction difficulty so its antioxidant compound could not be extracted optimally. However, either leaves or seeds extract in this study are potential as antioxidant resources because there are no significant differences between antioxidant capacity of both extract.
Vitamin C and Total Sugar Content Characterization on 31 Accessions of Banana Collection of Banana Germplasm Plants of Yogyakarta
Authors: Indrasari Siti Dewi , Kristamtini Kristamtini , Wiranti Endang Wisnu 
Published: March 2018

<p>Banana is one of the tropical fruits that people like because it tastes good and contains good nutritional value that beneficial for health. The content of vitamin C and total sugar are an important character to complete the morphological characterization of banana accession that can be utilized by breeders in choosing accession as parent. The study aimed to determine the content of vitamin C and total sugar on 31 accessions of banana collection of Banana Germplasm Plants of Yogyakarta. The research was conducted at Banana Germplasm Plantation and Laboratory of Agricultural Technology Production of Gadjah Mada University, Yogyakarta from January to December 2016. The results indicated that 31 banana accessions showed their susceptibility to vitamin C content 60.42 <span style="text-decoration: underline;">+</span> 39.22 mg / 100 g and total sugar 22.06 <span style="text-decoration: underline;">+</span> 16.01%. High standard deviation values indicate the large diversity of banana accessions that were characterized, indicating that the accessions of each characterized banana were separate accessions of one another.</p>
La lutte pour la reconnaissance ?
Authors: De la Broise Patrice 
Published: March 2018

À travers un dispositif textuel à caractère déontique, cette communication interroge l’agentivité de codes professionnels, chartes et autres manifestes dans leur contribution performative à la professionnalisation des communicateurs. L’appareillage déontique qui sert une professionnalisation aux prises avec la multiplicité de métiers relevant de secteurs, champs et fonctions multiples, sert également la reconnaissance des associations, syndicats et autres représentants qui revendiquent leur légitimité de porte-parole. Par-delà un corpus documentaire restreint, cette communication interroge la manière dont des regroupements professionnels contribuent à une régulation interne et externe de leurs métiers et fonctions de référence. Ce faisant, l’analyse ouvre sur la lecture dynamique d’une structuration « par défaut » (législatif et réglementaire) où la segmentation n’opère pas seulement sur le mode de la différenciation de territoires à géométrie variable et la revendication de leur souveraineté, mais aussi par un travail d’accompagnement et d’encadrement des professionnels en exercice. Cette contribution constitue donc une invitation à poursuivre, dans l’espace francophone, l’analyse dynamique d’une professionnalisation disputée par de multiples instances représentatives, sur différents modes rhétoriques (juridique, déontologique, militant, casuistique…) et services (édition, événements, formation, conseil…) aux professionnels.
La RSE : mentir donne de si bons résultats
Authors: Dagenais Bernard 
Published: March 2018

À partir de l’analyse de dizaines d’exemples d’engagement d’entreprises internationales ou canadiennes en matière de responsabilité sociale, nous avons fait les constats suivants : (1) les politiques de RSE ne sont trop souvent que l’expression de vœux pieux; (2) elles ne sont assujetties à aucune obligation d’applications concrètes ; (3) elles peuvent être démenties par des pratiques contraires à la politique ; (4) elles sont rentables car le public croit davantage l’expression de générosité que les mensonges qui les entourent. Dès lors, les entreprises ne se gênent aucunement pour projeter d’elles-mêmes une image d’entreprise responsable tout en ayant des pratiques condamnables, car en général la sanction de l’opinion publique n’est pas au rendez-vous. L’exemple des Prix Pinocchio en France en témoigne.
Having analysed dozens of examples of the commitment of international and Canadian businesses in the area of social responsibility, we arrive at the following observations: (1) CSR policies are all too often merely a matter of lip service; (2) they do not involve any obligation to apply concrete measures; (3) they may be contradicted by practices that are contrary to the policy; (4) they are profitable because public belief is more strongly influenced by the expression of generosity than by the fact of the lies surrounding them. As a result, businesses do not hesitate to project the image of a responsible enterprise while engaging in reprehensible practices, because in general public opinion does not cast blame upon them for doing so. The example of the Pinocchio Awards in France is a reflection of this.