bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and context of racism experienced by older Aboriginal and Torres Strait Islanders
Authors: Temple Jeromey B , Kelaher Margaret , Paradies Yin 
Published: January 2019

ObjectiveTo examine the prevalence and context of racism self‐reported by older Aboriginal and Torres Strait Islander people.MethodsThe 2015 National Aboriginal and Torres Strait Islander Survey was used to measure the prevalence, contexts and demographic differences in reports of racism. Multivariable logistic regression was used to examine the association of age with racism in later life.ResultsA sizeable minority of older Aboriginal people reported experiences of unfair treatment (31%) and avoidance (15%), oftentimes occurring in contexts critical to human capital investments. Specific demographic groups, including those with higher levels of education, were more likely to report experiences of unfair treatment. The prevalence of unfair treatment and avoidance remains relatively high in later life (albeit lower than younger ages), with a significant reduction from age 65.ConclusionAddressing racism, particularly in contexts crucial to human capital, is important for the health and well‐being of older Aboriginal people.
Symptoms related to posterior vitreous detachment and the risk of developing retinal tears: a systematic review
Authors: Gishti Olta , van den Nieuwenhof Ronald , Verhoekx Jennifer , van Overdam Koen 
Published: January 2019

AbstractFlashes and floaters are the hallmark symptoms of a posterior vitreous detachment (PVD) which itself is related to an increased risk of the development of retinal tears, retinal detachment and vitreous haemorrhage. The aim of this study is to assess the associations between different symptoms related to PVD and the risk of developing retinal tears. A systematic review of articles written in English, using MEDLINE, Embase (via Embase.com) and the Cochrane Controlled Trials Register (1996–2017) was conducted. Search terms included five elements: PVD, retinal tears, retinal detachment, floaters and flashes. Independent extraction of articles was conducted by two authors using predefined data fields, including study quality indicators. Thirteen studies fulfilled the selection criteria. Analysis of pooled data revealed that presence of isolated flashes was associated with the development of retinal tears in 5.3% of symptomatic eyes [mean 2.9 eyes; 95% CI (2.1, 5.7)].Conversely, floaters alone had a stronger association with retinal tears (16.5% of eyes), as compared to flashes. The association to retinal tears was even greater for those patients reporting both flashes and floaters [mean 17.8 eyes (20.0%); 95% CI (17.4, 18.1)]. Retinal and/or vitreous haemorrhage was also associated with the presence and later development of retinal tears [mean 12.5 eyes (30.0%); 95% CI (11.7, 13.9)]. Patients with more than 10 floaters or a cloud in their vision had a high risk of developing retinal tears (OR19.8, p‐value 0.032). In the setting of a PVD, the onset of flashes and floaters, and the presence of retinal and/or vitreous haemorrhage are risk factors for the development of retinal tears. The association is greater when both symptoms are present, and even greater when the patient reports more than 10 floaters, a curtain or a cloud and/or there is a positive finding of a vitreous or retinal haemorrhage. This study supports the necessity of an immediate examination of patients presenting with symptoms related to a PVD, and a follow‐up examination might be prudent in a subgroup of these patients.
An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery
Authors: Reidy Paul T. , Yonemura Nikol M. , Madsen Jared H. , McKenzie Alec I. , Mahmassani Ziad S. , Rondina Matthew T. , Lin Yu Kuei , Kaput Katie , Drummond Micah J. 
Published: January 2019

AbstractBackgroundMechanisms underlying physical inactivity‐induced insulin resistance are not well understood. In addition to a role in muscle repair, immune cell populations such as macrophages may regulate insulin sensitivity.AimThe aim of this study was to examine if the dynamic changes in insulin sensitivity during and after recovery from reduced physical activity corresponded to changes in skeletal muscle macrophages.MethodsIn this prospective clinical study, we collected muscle biopsies from healthy older adults (70 ± 2 years, n = 12) before and during a hyperinsulinaemic‐euglycaemic clamp and this occurred before (PRE) and after 2‐week reduced physical activity (RA), and following 2‐week of recovery (REC). Insulin sensitivity (hyperinsulinaemic‐euglycaemic clamp), skeletal muscle mRNA expression of inflammatory markers, and immunofluorescent quantification of skeletal muscle macrophages, myofibre‐specific satellite cell and capillary content were assessed.ResultsInsulin sensitivity was decreased following reduced activity and rebounded following recovery above PRE levels. We observed an increase (P < 0.01) in muscle macrophages (CD68+CD206+: 190 [55, 324]; CD11b+CD206+: 117 [28, 205]% change from PRE) and CD68 (2.4 [1.4, 3.4]‐fold) and CCL2 (1.9 [1.3, 2.5]‐fold) mRNA following RA concurrent with increased (P < 0.03) satellite cells (55 [6, 104]%) in slow‐twitch myofibres. Moreover, the distance of satellite cells to the nearest capillary was increased 7.7 (1.7, 13.7) µm in fast‐twitch myofibres at RA (P = 0.007). Changes in macrophages were positively associated with increased insulin sensitivity following RA (R > 0.57, P < 0.05).ConclusionThese findings suggested that a dynamic response of skeletal muscle macrophages following acute changes in physical activity in healthy older adults is related to insulin sensitivity.
Health care professionals' attitudes towards deprescribing in older patients with limited life expectancy: A systematic review
Authors: Lundby Carina , Graabæk Trine , Ryg Jesper , Søndergaard Jens , Pottegård Anton , Nielsen Dorthe Susanne 
Published: January 2019

AimsThe aim of this systematic review was to explore health care professionals' attitudes towards deprescribing in older people with limited life expectancy.MethodsA systematic literature search was conducted from inception to December 2017 using MEDLINE, EMBASE and CINAHL. Studies were included if they specifically concerned older people (≥65 years) with limited life expectancy, including those residing in any type of aged care facility, or were based on representative patient profiles. Results were analyzed inspired by the Joanna Briggs Institute's method for synthesis of qualitative data. Studies were characterized using a checklist for reporting of qualitative research.ResultsEight studies were included. Six studies explored health care professionals' views on deprescribing in general, and two studies focused specifically on psychotropic agents. All eight studies explored the views of physicians, mostly general practitioners, while three studies also considered other health care professionals. Four themes related to health care professionals' attitudes towards deprescribing were identified: (i) patient and relative involvement; (ii) the importance of teamwork; (iii) health care professionals' self‐assurance and skills; and (iv) the impact of organizational factors. Within each of these themes, 3–4 subthemes were identified and analysed.ConclusionsOur results suggest that health care professionals' decisions to engage in deprescribing activities with older people with limited life expectancy depend on multiple factors which are highly interdependent. Consequently, there is an urgent need for more research on how to approach deprescribing in clinical practice within this population.
Neuroimmune nexus of depression and dementia: Shared mechanisms and therapeutic targets
Authors: Herman Francis J. , Simkovic Sherry , Pasinetti Giulio M. 
Published: January 2019

Dysfunctional immune activity is a physiological component of both Alzheimer's disease (AD) and major depressive disorder (MDD). The extent to which altered immune activity influences the development of their respective cognitive symptoms and neuropathologies remains under investigation. It is evident, however, that immune activity affects neuronal function and circuit integrity. In both disorders, alterations are present in similar immune networks and neuroendocrine signalling pathways, immune responses persist in overlapping neuroanatomical locations, and morphological and structural irregularities are noted in similar domains. Epidemiological studies have also linked the two disorders, and their genetic and environmental risk factors intersect along immune‐activating pathways and can be synonymous with one another. While each of these disorders individually contains a large degree of heterogeneity, their shared immunological components may link distinct phenotypes within each disorder. This review will therefore highlight the shared immune pathways of AD and MDD, their overlapping neuroanatomical features, and previously applied, as well as novel, approaches to pharmacologically manipulate immune pathways, in each neurological condition.Linked ArticlesThis article is part of a themed section on Therapeutics for Dementia and Alzheimer's Disease: New Directions for Precision Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.18/issuetoc
L'identification des zones calmes et un diagnostic d’équité environnementale à Montréal
Authors: Delaunay Déborah , Apparicio Philippe , Séguin Anne‐Marie , Gelb Jérémy , Carrier Mathieu 
Published: January 2019

Messages clés

9,6 % du territoire est identifié comme des zones calmes potentielles.
Il y a des disparités spatiales importantes en termes de répartition des zones calmes selon les arrondissements et les municipalités.
Il n'y a pas d'iniquités importantes relativement à l'accessibilité aux zones calmes pour les groupes de population étudiés.
Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation
Authors: Harada Kazuaki , Ihara Fumie , Takami Mariko , Kamata Toshiko , Mise Naoko , Yoshizawa Hiroko , Hishiki Tomoro , Saito Takeshi , Terui Keita , Nakata Mitsuyuki , Komatsu Shugo , Ikeuchi Takayuki , Nakayama Toshinori , Yoshida Hideo , Motohashi Shinichiro 
Published: January 2019

Dendritic cells (DC) play a key role in the initiation of both antitumor immunity and immunological tolerance. It has been demonstrated that exposure to soluble factors produced by tumor cells modulates DC functions and induces tolerogenic DC differentiation. In this study, we investigated the effects of neuroblastoma cell line‐derived soluble factors on DC differentiation. Monocytes isolated from healthy volunteers were incubated with interleukin (IL)‐4 and granulocyte‐macrophage colony‐stimulating factor in the presence of culture supernatants from neuroblastoma cell lines. The culture supernatants from neuroblastoma cell lines, such as NLF and GOTO, partially blocked both downregulation of CD14 and upregulation of CD1a, and dramatically decreased IL‐12 and tumor necrosis factor (TNF)‐α production from mature DC, while no effect of SH‐SY5Y cell supernatant was noted. In addition, IL‐6 and IL‐10 production from monocytes was increased by the supernatants of NLF and GOTO cells at 24 hours after incubation. Furthermore, we evaluated DC functions through stimulation of invariant natural killer T (iNKT) cells. α‐Galactosylceramide‐pulsed DC co‐cultured with supernatants of NLF cells were unable to sufficiently stimulate iNKT cells. The decreased ability of iNKT cells to produce interferon (IFN)‐γ after stimulation with neuroblastoma cell line supernatant‐cultured DC was reversed by addition of IL‐12. CD40 expression and IL‐12 production in NLF‐sup‐treated DC were increased by addition of exogenous IFN‐γ. These results indicate that tolerogenic DC are induced in the neuroblastoma tumor microenvironment and attenuate the antitumor effects of iNKT cells. Interactions between iNKT cells and αGalCer‐pulsed DC have the potential to restore the immunosuppression of tolerogenic DC through IFN‐γ production.
Loading capacity of CAD/CAM‐fabricated anterior feldspathic ceramic crowns bonded to one‐piece zirconia implants with different cements
Authors: Nueesch Reto , Conejo Julian , Mante Francis , Fischer Jens , Märtin Sabrina , Rohr Nadja , Blatz Markus B. 
Published: January 2019

AbstractObjectiveThis study evaluated the loading capacity of CAD/CAM‐fabricated anterior feldspathic ceramic crowns bonded to one‐piece zirconia implants with different cements.Material and methodsFifty one‐piece zirconia implants were embedded in epoxy resin. The abutment aspect of one implant was optically scanned and a standardized upper canine was designed with CAD‐software. Fifty feldspathic ceramic crowns were milled, polished, and mounted on the implants either without any cement, with a temporary cement or with three different composite resin cements after surface pretreatment as recommended by the manufacturers (n = 10). After storage in distilled water at 37°C for 24 hr, specimens were loaded until fracture on the palatal surface of the crown at an angle of 45° to the long axis of the implant and loads until fracture were detected and compared. Compressive strength of the investigated cement materials was determined. Statistical analyses were done with One‐way ANOVA followed by post hoc Fisher LSD test (α = 0.05).ResultsThe cements revealed significantly different compressive strength values (temporary cement: 37.1 ± 7.0 MPa; composite resin cements: 185.8 ± 21.3, 277.9 ± 22.1, and 389.0 ± 13.6 MPa, respectively). Load‐at‐fracture values had an overall mean value of 237.1 ± 58.2 N with no significant difference among the composite resin cements (p > 0.05). Fracture load values with the temporary cement or without cement were significantly lower (p < 0.002).ConclusionsCAD/CAM‐fabricated anterior feldspathic ceramic crowns bonded to one‐piece zirconia implants provide sufficient resistance to intraoral forces.
A dark scenario for Cerrado plant species: Effects of future climate, land use and protected areas ineffectiveness
Authors: Velazco Santiago José Elías , Villalobos Fabricio , Galvão Franklin , De Marco Júnior Paulo 
Published: January 2019

AbstractAimThe anthropogenic climate change and land use change are considered two of the main factors that are altering biodiversity at the global scale. An evaluation that combined both factors can be relevant to detect which species could be the most vulnerable and reveal the regions of highest stability or susceptibility to biodiversity. We aimed to: (a) assess the effect of climate change and land use on the distribution of Cerrado plant species for different countries where they occur, (b) evaluate the effectiveness of the current network of protected areas (PAs) to safeguards species under different greenhouse–gas (GHG) emissions and land use scenarios, and (c) estimate the vulnerability of species based on protection effectiveness and habitat loss.LocationBolivia, Brazil and Paraguay.MethodsWe modelled the distribution of 1,553 plant species of Cerrado and evaluated species range loss caused by present and future land use and two GHG for 2050 and 2080. We assessed species vulnerability combining the representativeness of species within conservation units with the loss of species’ ranges outside PAs.ResultsWe found that climate change and land use will cause great damage to Cerrado flora by 2050 and 2080, even under optimistic conditions. The greatest impacts of land use will occur in the regions where the greatest richness will be harboured. The conservation of the species will be seriously affected since the PA network is not as effective in safeguarding them under current or future conditions.Main conclusionsThe low level of protection together with the losses caused by the advance of agricultural lands will lead most species being highly vulnerable. Due to the distinct impacts of climate and land use over the three countries, conservation strategies should be implemented at transboundary and national levels.
Prevalence and risk factors of constipation and pollakisuria among older home‐care patients
Authors: Komiya Hitoshi , Umegaki Hiroyuki , Asai Atsushi , Kanda Shigeru , Maeda Keiko , Nomura Hideki , Kuzuya Masafumi 
Published: January 2019

AimThe prevalence of constipation and prevalence of pollakisuria among older patients receiving home medical care have not been reported, and risk factors for these symptoms are not clear in this setting. The present study sought to determine the prevalence and risk factors of constipation and pollakisuria among older patients receiving home medical care in Japan.MethodsThis study utilized data from patients in the Observational Study of Nagoya Elderly with Home Medical Care (n = 153). We carried out univariate and multivariate logistic regression analyses with the presence of constipation or pollakisuria as the dependent variable to evaluate the relationships between constipation or pollakisuria and several covariates.ResultsThe prevalence of constipation and pollakisuria were 56.9% and 15.7%, respectively. Multivariate logistic analysis showed that constipation was associated with Charlson Comorbidity Index score, polypharmacy and pollakisuria, and pollakisuria was associated with constipation and insomnia. Cardiovascular disease was inversely associated with constipation.ConclusionsThe prevalence of constipation among home‐care patients was as high as that reported for nursing home residents and higher than that among community‐dwelling individuals. Clinicians should be aware of increased constipation risk among home‐care patients, particularly for those with a high Carlson Comorbidity Index score, polypharmacy and/or pollakisuria. Geriatr Gerontol Int 2019; 19: 277–281.
A novel Nd3+‐doped MgO‐Al2O3‐SiO2‐based transparent glass‐ceramics: Toward excellent fluorescence properties
Authors: Han Lei , Li Cui , Lin Chang‐wei , Liu Jian‐lei , Wu Jia‐qi , Gui Hua , Zhang Qian , Luo Zhi‐wei , Liu Tao‐yong , Lu An‐xian 
Published: January 2019

AbstractGenerally, glass‐ceramics have superior properties compared to their parent glasses. Here, we prepared a novel Nd3+‐doped MgO‐Al2O3‐SiO2‐based transparent glass‐ceramics with excellent fluorescence properties. The effects of Nd2O3 content on the structure and properties of glass‐ceramics were studied, aiming to provide a key guidance for preparing this transparent glass‐ceramics. The results revealed that the glass stability increased originally and then decreased with increasing Nd2O3 content, so did the variation of wavenumbers in infrared spectra. And these glass‐ceramics are mainly composed of cordierite with residual glassy phase. The three phenomenological intensity parameters (Ω2,4,6) and radiative properties were estimated by Judd‐Ofelt theory, and the values of Ω2 first decreased and then increased with increasing Nd2O3 content. Three main emission peaks ascribed to the transitions from 4F3/2 to 4I9/2, 4I11/2, 4I13/2 at 898, 1057, 1330 nm were observed, respectively. The branching ratios for 4F3/2→4I11/2 transition increased as the Nd2O3 content raised, and the fluorescence lifetimes of the 4F3/2 level were found to increase first and then decrease with Nd2O3 content (from 181 to 726 μs). The excellent fluorescence properties indicate that this novel glass‐ceramics can be used as a potential solid‐state optical functional material for 1.06 μm laser emission.
Electoral Quid Pro Quo: A Defence of Barter Markets in Votes
Authors: Volacu Alexandru 
Published: January 2019

AbstractIn this article I aim to provide the first normative discussion of barter voting markets, namely markets which allow the trading of votes on issues/elections for votes on other issues/elections. The article is framed within the wider literature on the legal permissibility of vote buying, with a particular focus on the recent debate between Christopher Freiman and James Stacey Taylor. I argue that while Taylor's objections successfully defeat Freiman's case in favour of standard voting markets, they are unable to also defeat the type of voting markets outlined here. Furthermore, I argue that there are at least two plausible prima facie reasons in favour of barter voting markets, grounded in their capacity to contribute to the alleviation of injustice for systematically disadvantaged socio‐economic groups and to their capacity to reduce one form of bad voting, i.e. voting from ignorance.
Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF‐1α signalling
Authors: Xu Wei , Xu Ruijun , Li Zhikun , Wang Yi , Hu Ruixi 
Published: January 2019

AbstractMesenchymal stem cells (MSCs) have drawn great attention because of their therapeutic potential. It has been suggested that intra‐venous infused MSCs could migrate the site of injury to help repair the damaged tissue. However, the mechanism for MSC migration is still not clear so far. In this study, we reported that hypoxia increased chemotaxis migration of MSCs. At 4 and 6 hours after culturing in hypoxic (1% oxygen) conditions, the number of migrated MSCs was significantly increased. Meanwhile, hypoxia also increased the expression of HIF‐1α and SDF‐1. Using small interference RNA, we knocked down the expression of HIF‐1α in MSCs to study the role of HIF‐1α in hypoxia induced migration. Our data indicated that knocking down the expression of HIF‐1α not only abolished the migration of MSCs, but also reduced the expression of SDF‐1. Combining the results of migration assay and expression at RNA and protein level, we demonstrated a novel mechanism that controls the increase of MSCs migration. This mechanism involved HIF‐1α mediated SDF‐1 expression. These findings provide new insight into the role of HIF‐1α in the hypoxia induced MSC migration and can be a benefit for the development of MSC‐based therapeutics for wound healing.
Biologic modelling of periodontal disease progression
Authors: Nagarajan Radhakrishnan , Miller Craig S. , Dawson Dolph , Ebersole Jeffrey L. 
Published: January 2019

AbstractAimTo investigate the synergistic role of biologic markers from saliva, serum and plaque in modelling periodontitis disease progression.Material and MethodsThis longitudinal study evaluated characteristics of disease progression in 114 patients with generalized moderate to severe periodontitis. The primary outcome was detection of sites with progressing attachment loss sites over 6 months in patients who received scaling and root planing or oral hygiene only. The predictive potential of 27 biomarkers in serum, whole saliva and subgingival plaque was evaluated using three classification algorithms (Support Vector Machines; Naïve Bayes Classifier; and Linear Discriminant Analysis) within an ensemble predictive modelling framework.ResultsDisease progression occurred in 24.6% of subjects (28/114). Predictive modelling using Naïve Bayes Classifier identified progressors best with sensitivity of ~89%. The use of the three classification algorithms revealed the concerted role of salivary matrix metalloproteinase‐8, serum biomarkers (serum amyloid P, matrix metalloproteinase 1, bactericidal permeability‐increasing protein, isoprostane) along with levels of Porphryomonas gingivalis and Tannerella forsythia in plaque in predicting progressors.ConclusionsSynergistic utility of baseline bacterial and inflammatory biomarkers from saliva, serum and plaque predicted disease progression.