bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of surgical and radiological interventions for thrombosed arteriovenous access
Authors: Lambert Gary , Freedman Jonathan , Jaffe Susan , Wilmink Teun 
Published: March 2018

Introduction: To compare open surgical and radiological interventions for thrombosed arteriovenous access for dialysis. Methods: A retrospective analysis of access procedures and dialysis episodes from 1 December 2002 to 30 November 2015 with follow-up up to 1 August 2016. Hospital records and dialysis database interrogated for further interventions and length of functional use. Results: Some 128 surgical and 27 radiological thrombectomies were compared. Radiological treatment was successful in 24 (89%) cases and surgical interventions in 65 cases (51%; p < 0.001). In all, 82 (64%) of the 128 surgical thrombectomies had no additional treatment, 43 (34%) had a surgical revision and 3 cases (2%) had an on-table balloon angioplasty. All 27 interventional thrombectomies had an additional balloon angioplasty. Success rate was significantly increased after a surgical revision (74%) or balloon angioplasty (87%) compared to no adjuvant procedure (38%; p < 0.001). There was a trend towards higher primary failure rates of arteriovenous fistula thrombectomies in the upper arm (57%) compared to the arteriovenous fistula thrombectomies in forearm (40%) and arteriovenous graft thrombectomies (33%; p = 0.056). Assisted primary patency was better after interventional treatment compared to surgery (p = 0.02) and significantly better after thrombectomy with additional treatment (p = 0.005). Patency after surgical revision or balloon angioplasty of the access was similar (p = 0.15). More procedures were required to maintain the access after balloon angioplasty than after surgical revision, and intervention-free survival was better after surgical revision (p = 0.02). Conclusion: Revision procedures significantly increase success rate of access thrombectomies. Radiological thrombectomies have higher success rates but lower intervention-free survival and need more additional procedures to maintain patency.
Clinical outcomes of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions compared with the natural course: a propensity score matching analysis
Authors: Choi Jin Ho , Lee Sang Hyub , Choi Young Hoon , Kang Jinwoo , Paik Woo Hyun , Ahn Dong-Won , Ryu Ji Kon , Kim Yong-Tae 
Published: March 2018

Background Endoscopic ultrasound-guided ethanol ablation (EUS-EA) is a recently introduced treatment for pancreatic cystic lesions (PCLs). However, clinical benefits such as survival gain and maintenance of quality of life (QOL) have not been fully established. The aim of this study was to evaluate the clinical benefits of EUS-EA compared with the natural course (NC) of PCLs. Methods This retrospective comparative study of patients with PCLs investigated an EUS-EA group ( n = 118) and an NC group ( n = 428). Propensity score matching (PSM) analysis was applied to minimize the effects of selection bias. The overall survival as the primary outcome and the surgical resection rate and complete remission (CR) rate as the secondary outcomes were evaluated. Results Between 84 matched pairs of both groups, there were no significant differences in the baseline clinical characteristics and the mean follow-up duration (78.88 ± 38.86, 75.90 ± 57.46 months, p = 0.694). Overall survival did not differ significantly (194.12 ± 5.60, 247.54 ± 12.70 months, p = 0.235). The surgical resection rate (4.8% versus 26.2%, p < 0.001) was significantly lower in the EUS-EA group. CR was observed only in the EUS-EA group and the CR rate was 32.1%. Conclusions EUS-EA for PCLs with low risk of malignancy might not be able to obtain a survival benefit, but showed maintenance of QOL by avoidance of unnecessary surgery, and a certain level of CR when compared to the NC. EUS-EA could be considered a useful treatment option for these, but careful application is needed because of the limited effects in some types of PCLs.
Understanding health food messages on Twitter for health literacy promotion
Authors: Zhou J , Liu F , Zhou H 
Published: March 2018

Aims: With the popularity of social media, Twitter has become an important tool to promote health literacy. However, many health-related messages on Twitter are dead-ended and cannot reach many people. This is unhelpful for health literacy promotion. This article aims to examine the features of online health food messages that people like to retweet. Methods: We adopted rumour theory as our theoretical foundation and extracted seven characteristics (i.e. emotional valence, attractiveness, sender’s authoritativeness, external evidence, argument length, hashtags, and direct messages). A total of 10,025 health-related messages on Twitter were collected, and 1496 messages were randomly selected for further analysis. Each message was treated as one unit and then coded. All the hypotheses were tested with logistic regression. Results: Emotional valence, attractiveness, sender’s authoritativeness, argument length, and direct messages in a Twitter message had positive effects on people’s retweet behaviour. The effect of external evidence was negative. Hashtags had no significant effect after consideration of other variables. Conclusion: Online health food messages containing positive emotions, including pictures, containing direct messages, having an authoritative sender, having longer arguments, or not containing external URLs are more likely to be retweeted. However, a message only containing positive or negative emotions or including direct messages without any support information will not be retweeted.
L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary
Authors: Coux Rémi-Xavier , Teixeira Felipe Karam , Lehmann Ruth 
Published: March 2018

ABSTRACT
Maintenance of cellular identity is essential for tissue development and homeostasis. At the molecular level, cell identity is determined by the coordinated activation and repression of defined sets of genes. The tumor suppressor L(3)mbt has been shown to secure cellular identity in Drosophila larval brains by repressing germline-specific genes. Here, we interrogate the temporal and spatial requirements for L(3)mbt in the Drosophila ovary, and show that it safeguards the integrity of both somatic and germline tissues. l(3)mbt mutant ovaries exhibit multiple developmental defects, which we find to be largely caused by the inappropriate expression of a single gene, nanos, a key regulator of germline fate, in the somatic ovarian cells. In the female germline, we find that L(3)mbt represses testis-specific and neuronal genes. At the molecular level, we show that L(3)mbt function in the ovary is mediated through its co-factor Lint-1 but independently of the dREAM complex. Together, our work uncovers a more complex role for L(3)mbt than previously understood and demonstrates that L(3)mbt secures tissue identity by preventing the simultaneous expression of original identity markers and tissue-specific misexpression signatures.
Molecular mobility and activity in an intravital imaging setting – implications for cancer progression and targeting
Authors: Nobis Max , Warren Sean C. , Lucas Morghan C. , Murphy Kendelle J. , Herrmann David , Timpson Paul 
Published: March 2018

ABSTRACT
Molecular mobility, localisation and spatiotemporal activity are at the core of cell biological processes and deregulation of these dynamic events can underpin disease development and progression. Recent advances in intravital imaging techniques in mice are providing new avenues to study real-time molecular behaviour in intact tissues within a live organism and to gain exciting insights into the intricate regulation of live cell biology at the microscale level. The monitoring of fluorescently labelled proteins and agents can be combined with autofluorescent properties of the microenvironment to provide a comprehensive snapshot of in vivo cell biology. In this Review, we summarise recent intravital microscopy approaches in mice, in processes ranging from normal development and homeostasis to disease progression and treatment in cancer, where we emphasise the utility of intravital imaging to observe dynamic and transient events in vivo. We also highlight the recent integration of advanced subcellular imaging techniques into the intravital imaging pipeline, which can provide in-depth biological information beyond the single-cell level. We conclude with an outlook of ongoing developments in intravital microscopy towards imaging in humans, as well as provide an overview of the challenges the intravital imaging community currently faces and outline potential ways for overcoming these hurdles.
Knowing the team around your patient
Authors: Stonehouse David 
Published: March 2018

There are many different professionals who all contribute to the health and support of patients. Understanding each one's different specialty is important, so that support workers know who the patient needs to be involved in their care—and when. The Code of Conduct for Healthcare Support Workers and Adult Social Care Workers in England ( Skills for Care and Skills for Health, 2013 ) identifies that working in collaboration with colleagues is an important part of the support worker's role. Within section three and four it highlights three key areas: support workers must ‘recognise and respect the roles and expertise of your colleagues both in the team and from other agencies and disciplines, and work in partnership with them’; ‘work openly and cooperatively with colleagues, including those from other disciplines and agencies, and treat them with respect’; and ‘communicate effectively and consult with your colleagues as appropriate’. These three keys areas of partnership working, respect and communication will be explored and discussed in this article.
As valas abertas
Authors: Seiça Álvaro 
Published: March 2018

as valas abertas ++ des fossés ouverts ++ open ditches é um poema composto por 40 linhas com o máximo de 80 caracteres por linha. O poema explora regras de composição e temas presentes no conto “A Biblioteca de Babel” (1941) de Jorge Luis Borges. O poema foi criado como resposta a um desafio, Langlibabex (2014), uma peça de poesia simultânea multilíngue desenvolvida em colaboração com Claire Donato e Luc Dall’Armellina.
Em as valas abertas ++ des fossés ouverts ++ open ditches coexistem níveis e funções plurais de modos de leitura, visto que o navegador e a voz humana reproduzem a leitura do código fonte com uma saída visual e emissão sonora distintas. A voz humana apresenta uma leitura literal do código HTML, enquanto que a leitura do navegador omite certas passagens que estão inseridas dentro de marcadores HTML inventados e não-estandardizados, que se relacionam com o corpo humano dentro do marcador <body>. Os vários corpos realçam fricções e tensões entre agentes humanos e não-humanos na sua relação com a linguagem e o código: as linguagens ditas “naturais” e as linguagens de programação.
Na altura em que o poema foi escrito, corpos vivos cavavam inúmeras valas abertas na Ucrânia, que estavam já destinadas a futuros corpos mortos, mas desconhecidos. O poema entrelaça este facto com os factos ficcionais de Borges. Foi composto e gravado em Paris, em Novembro de 2014, em português, inglês, francês e HTML. O poema e o ficheiro mp3 podem ser descarregados em http://alvaroseica.net/works/as-valas-abertas.html
Galaxia vocálica
Authors: Italiano Juan Angel 
Published: March 2018

Galaxia vocálica (00:05:27) es una posible interpretación sonora del texto de Pedro Xisto “VOGALAXIA” (Ed. Invenção / San Paulo – 1966) en el que las vocales (elemento de trabajo) están relacionadas entre sí. La oralización de la obra, sigue las sugerencias del autor, las vocales suenan abiertas o cerradas, nasales, acentuadas, susurradas, aceleradas, cantadas, solas o en coros, en una permutación constante. La lectura de las secuencias fueron verticales, horizontales, transversales o circulares, buscando la construcción de una representación sonora de un universo vocálico, de una galaxia de vocales. Incluye el sonido modificado de una prominencia solar captada por el A.I.A. instrument multiband del Solar Dynamics Observatory (NASA). Se buscó a la hora de la edición explotar las diferentes direcciones del paneo, para generar la idea de multiplicidad de fuentes de origen del sonido.
Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas
Authors: Sbardella Emilia , Minnetti Marianna , D’Aluisio Denise , Rizza Laura , Di Giorgio Maria Rosaria , Vinci Fabio , Pofi Riccardo , Giannetta Elisa , Venneri Mary Anna , Vestri Annarita , Morelli Sergio , Lenzi Andrea , Isidori Andrea M 
Published: March 2018

Background
Low-grade incomplete post-dexamethasone cortisol suppression in patients with adrenal incidentalomas – recently defined as possible autonomous cortisol secretion (pACS) – has been associated with increased cardiovascular events and mortality. However, prospective studies documenting cardiac abnormalities in these patients are lacking.

Subjects and methods
Between July 2016 and September 2017, 71 consecutive patients with adrenal lesions were prospectively screened for hypercortisolism by dexamethasone suppression test (NCT 02611258). Complete anthropometric, metabolic and hormonal parameters were recorded along with full cardiac ultrasound assessment and noninvasive measurement of arterial stiffness. All patients underwent chemical-shift magnetic resonance imaging to characterize the lesions. Cardiovascular outcomes were recorded in blind.

Results
According to post-dexamethasone suppression cortisol values (post-DST), 34 patients had pACS and 37 non-functioning adenomas (NFA). The two groups were similar in sex, BMI, age distribution, cardiovascular risk factors and comorbidities. Left ventricular mass index (LVMIBSA) was increased in pACS compared to NFA (P = 0.006) and mildly correlated to the post-DST cortisol level (rho = 0.347; P = 0.004). The post-DST cortisol levels explained up to 13.7% of LVMIBSA variance (P = 0.002). Compared to NFA, patients with pACS had a higher prevalence of diastolic dysfunction (35.1% vs 82.6%; P = 0.001) and worse arterial stiffness assessed by pulse wave velocity (P = 0.033).

Conclusions
In apparently asymptomatic patients, mild autonomous cortisol secretion can sustain early cardiac and vascular remodeling, independently of other risk factors. The morphological and functional cardiovascular changes observed in pACS underline the need for further studies to correctly define the long-term management of this relatively common condition.
Hormonal Treatment in Young People With Gender Dysphoria: A Systematic Review
Authors: Chew Denise , Anderson Jemma , Williams Katrina , May Tamara , Pang Kenneth 
Published: March 2018

CONTEXT:
Hormonal interventions are being increasingly used to treat young people with gender dysphoria, but their effects in this population have not been systematically reviewed before.

OBJECTIVE:
To review evidence for the physical, psychosocial, and cognitive effects of gonadotropin-releasing hormone analogs (GnRHa), gender-affirming hormones, antiandrogens, and progestins on transgender adolescents.

DATA SOURCES:
We searched Medline, Embase, and PubMed databases from January 1, 1946, to June 10, 2017.

STUDY SELECTION:
We selected primary studies in which researchers examined the hormonal treatment of transgender adolescents and assessed their psychosocial, cognitive, and/or physical effects.

DATA EXTRACTION:
Two authors independently screened studies for inclusion and extracted data from eligible articles using a standardized recording form.

RESULTS:
Thirteen studies met our inclusion criteria, in which researchers examined GnRHas (n = 9), estrogen (n = 3), testosterone (n = 5), antiandrogen (cyproterone acetate) (n = 1), and progestin (lynestrenol) (n = 1). Most treatments successfully achieved their intended physical effects, with GnRHas and cyproterone acetate suppressing sex hormones and estrogen or testosterone causing feminization or masculinization of secondary sex characteristics. GnRHa treatment was associated with improvement across multiple measures of psychological functioning but not gender dysphoria itself, whereas the psychosocial effects of gender-affirming hormones in transgender youth have not yet been adequately assessed.

LIMITATIONS:
There are few studies in this field and they have all been observational.

CONCLUSIONS:
Low-quality evidence suggests that hormonal treatments for transgender adolescents can achieve their intended physical effects, but evidence regarding their psychosocial and cognitive impact are generally lacking. Future research to address these knowledge gaps and improve understanding of the long-term effects of these treatments is required.
HUBUNGAN ANTARA TINGKAT AKTUALISASI DIRI DENGAN KEBERMAKNAAN HIDUP PADA PRIA HOMOSEKSUAL
Authors: Septiani Nia H. 
Published: March 2018

This research specifically observes the correlation between self actualization level and life meaning of homosexual men in a Bandung association. This research has been done because condition of society who has not been able to accept the existing of homosexual men in the association, many probles must be faced by them which enables to disturb their actualization with assumption that it relates to their life meaning. The design used in this research is non experimental design and correlation method. The research data are taken from the measurement tool encompassing self actualization data based on theory concept said by Maslow (1984). Whereas, the measurement tool used to get the date of the life meaning composed by James Crumbaugh dan Leonard Maholick (Frankl, 1984) named The Purpose in Life Test. The result of analysis shows that correlative coefficient of both variables is 0.685 with Pv = 0,000 on significant standard α= 0,05 by two side tests. Basing on the result of significant test, it is known that thitung = 4,98. The result of data analysis shows that correlative coefficient of both variables is 0.685 with Pv = 0,000 on significant standard α= 0,05 by two side tests.basing on the result of significant test, it is known that thitung = 4,98. With standard significance α=0,05 and (dkn-2) =28 for two side test, it is know that ttabel = 2.048. These results show that there is significant positive correlation between self actualization and life meaning.
HUBUNGAN ANTARA KREATIVITAS DENGAN PRESTASI BELAJAR SISWA
Authors: Komarudin Dindin 
Published: March 2018

One of aspects that can encourage students in order to be able to get achievement in education is creativity, i.e., a mental process in which experiences in the past is recombined often with a form changed. This research is done to know the correlation between creativity and study achievement. Related to it, non-experimental with correlation method is used. Creativity is measured by using verbal and figural creativity test composed by Torrence (Munandar, 1977) with ordinal scale study achievement is measured by looking the cumulative value of student reports in the last of semester which is put into the ordinal scale. Because both the scales have interval scale, so the hypothesis test used is the formula of Pearson correlation. Based on the result of significance test, it is gotten that thitung is 1,07. With standard of significance α=0,05and (dkn-2) =44for the test of both sides, it is gotten ttabel =2.02. The criteria test used is repelling H0 if thitung is the same as or higher than ttabel. However thitung = 1,07is not higher than ttabel =2,02 on the standard of significance=0,05,therefore H0 is accepted. So, it can be said that there is no the significant positive correlation between creativity and study achievement.
HUBUNGAN ANTARA TIPE KEPRIBADIAN MENURUT EYSENCK DENGAN KOMITMEN ORGANISASI PADA OSIS SMAN 2 CIMAHI
Authors: Kadir Asep Abdul , Hikmawati Fenti , Gamayanti Witrin 
Published: March 2018

This research based on phenomena of students council in which teamwork is really needed to get the organization goal. Before having teamwork, individu must have commitment to organization and level of commitment is assumed correlated with personality types. Eysenck (1974) defined personality as a result of interaction between inherited factors and surrounding. According to Porter (Schultz, 1982: 4), commitment on organization is individual attitude having trust and acceptance to the goal and values of organization. This research used correlational methodology. Result found χ2hitung is 5.013 which is compared to χ2tabel 3.84 (Siegel, 1997: 301). Since χ2hitung = 5.013 is more than χ2tabel 3.84 on significant level 0,05, then Ho is not accepted. Therefore, it is concluded that there is correlation between personality type and organizational commitment.
PROGRAM PENINGKATAN KEMAMPUAN ORANG TUA DAN GURU DALAM MEMBANTU KEMANDIRIAN SHOLAT ANAK TUNAGRAHITA RINGAN
Authors: Tarsono Tarsono 
Published: March 2018

This research aims to help mentally disabled students to pray independently by giving suggestion to parrents and teachers. Qualitative approach using interview, observation and documentation are used to collect data. Result shows that some mentally disabled students have not been able to have five times praying with correct reading prayer and movement. Parents can ask to pray together, invite teacher and provide some media. Meanwhile, teacher could make schedule for praying together and make a realia. Constraints faced are lack of mentally disabled knowledge, no appropriate realia and lack of attention toward mentally disabled students.
FLUVASTATİNİN TAVŞAN KAROTİD ARTERİ YAKA MODELİNDE İNTİMAL KALINLAŞMA ÜZERİNE ETKİLERİ
Authors: ARUN Mehmet Zuhuri , SEVİN Gülnur , AYLA Şule , ÖKTEM Gülperi , YETİK ANACAK Günay , ÜSTÜNES Levent 
Published: March 2018

Amaç: Statinlerin
LDL-kolesterol düşürücü etkilerinden bağımsız endotel fonksiyonu gibi aterosklerozun
pek çok bileşeni üzerinde de etkileri mevcuttur. Bu etkileri pleiotropik
etkileri olarak da bilinmektedir. Bu çalışmada fluvastatinin normokolesterolemik
tavşanlarda intimal kalınlaşma üzerine etkisinin araştırılması planlanmıştır.Gereç ve Yöntem: Çalışmada Yeni Zelanda tavşanlarına 3 hafta boyunca
fluvastatin (8 mg/kg/gün oral) ve plasebo tedavi uygulandı. Tedavinin sekizinci
gününde okluzif olmayan silikon bir yaka sol karotid arterinin çevresine
yerleştirilerek on dört gün daha tedaviye devam edildi. Deney sonunda sağ ve
sol karotid arterler çıkarıldı. Çıkarılan karotid arterlerden alınan kesitlerde
morfometrik ölçümler gerçekleştirildi. İntima, medya, lümen ve eksternal
elastik lamina alanları ölçülerek indeks, rezidüel lümen oranı değerleri
hesaplandı.Bulgular: Yaka intimal
alan ve indeks değerinde belirgin bir artışa ve RLO değerinde azalmaya neden
olurken fluvastatin yakanın neden olduğu intimal kalınlaşmayı inhibe etti.Sonuç: Bulgularımız
fluvastatinin kolesterol düşürücü etkisinden bağımsız aterosklerozun erken
döneminde de yararlı etkileri olabileceğini göstermektedir.