bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning Technology for Classification of Thyroid Nodules Using Multi-view Ultrasound Images: Potential Benefits and Challenges in Clinical Application
Authors: Kim Jinyoung , Kim Min-Hee , Lim Dong-Jun , Lee Hankyeol , Lee Jae Jun , Kwon Hyuk-Sang , Kim Mee Kyoung , Song Ki-Ho , Kim Tae-Jung , Jung So Lyung , Lee Yong Oh , Baek Ki-Hyun 
Published: November 2024

Abstract

Background: This study aimed to evaluate the applicability of deep learning technology to thyroid ultrasound images for classification of thyroid nodules.
Methods: This retrospective analysis included ultrasound images of patients with thyroid nodules investigated by fine-needle aspiration (FNA) at the thyroid clinic of a single center from April 2010 to September 2012. Thyroid nodules with cytopathologic results of Bethesda category V (suspicious for malignancy) or VI (malignant) were defined as thyroid cancer. Multiple deep learning algorithms based on convolutional neural networks (CNNs) – ResNet, DenseNet, and EfficientNet – were utilized, and Siamese neural networks facilitated multi-view analysis of paired transverse and longitudinal ultrasound images.
Results: Among 1,048 analyzed thyroid nodules from 943 patients, 306 (29%) were identified as thyroid cancer. In a subgroup analysis of transverse and longitudinal images, longitudinal images showed superior prediction ability. Multi-view modeling, based on paired transverse and longitudinal images, significantly improved the model performance; with an accuracy of 0.82 (95% confidence intervals [CI] 0.80-0.86) with ResNet50, 0.83 (95% CI, 0.83-0.88) with DenseNet201, and 0.81 (95% CI, 0.79-0.84) with EfficientNetv2_s. Training with high-resolution images obtained using the latest equipment tended to improve model performance in association with increased sensitivity.
Conclusion: CNN algorithms applied to ultrasound images demonstrated substantial accuracy in thyroid nodule classification, indicating their potential as valuable tools for diagnosing thyroid cancer. However, in real-world clinical settings, it is important to aware that model performance may vary depending on the quality of images acquired by different physicians and imaging devices.
Metabolomic and lipidomic profiling for pre-transplant assessment of delayed graft function risk using chemical biopsy with microextraction probes
Authors: Warmuzińska Natalia , Łuczykowski Kamil , Stryjak Iga , Wojtal Emilia , Woderska-Jasińska Aleksandra , Masztalerz Marek , Włodarczyk Zbigniew , Bojko Barbara 
Published: November 2024

Abstract

Organ shortage remains a significant challenge in transplantology, prompting efforts to maximize the use of available organs and expand the donor pool, including through extended criteria donors (ECD). However, ECD kidney recipients often face poorer outcomes, including a higher incidence of delayed graft function (DGF), which is linked to worse graft performance, reduced long-term survival, and increased need for interventions like dialysis. This underscores the urgent need for strategies to improve early DGF risk assessment and optimize post-transplant management for high-risk patients. This study conducted multi-time point metabolomic and lipidomic analyses of donor kidney tissue and recipient plasma to identify compounds predicting DGF risk and assess the translational potential of solid-phase microextraction (SPME) for graft evaluation and early complication detection. SPME-based chemical biopsy enabled direct kidney analysis, while thin-film microextraction facilitated high-throughput plasma preparation. Following high-performance liquid chromatography coupled with mass spectrometry analysis, the Random Forest algorithm was applied to identify compounds with predictive potential for assessing DGF risk before transplantation. Additionally, a comparison of metabolomic and lipidomic profiles of recipient plasma during the early post-operative days identified metabolites that distinguish between DGF and non-DGF patients. The selected compounds primarily included amino acids and their derivatives, nucleotides, organic acids, peptides, and lipids, particularly phospholipids and triacylglycerols. In conclusion, this study highlights the significant translational potential of chemical biopsy and plasma metabolite analysis for risk assessment and non-invasive monitoring of DGF. The identified metabolites provide a foundation for developing a comprehensive DGF assessment and monitoring method, with potential integration into routine clinical practice.
A critical review on applications of machine learning in wastewater treatment: insights and implications for distillery wastewater
Authors: Nikhar Chaitali Kishor , Vyas Gayatri Sachin , Dalvi Rupa Sunil , Bhoye Dipak Yashwant 
Published: November 2024

ABSTRACT

The critical requirement for treating distillery wastewater is globally recognized due to its significant environmental impact and regulatory requirements. This paper reviews the literature on wastewater treatment, focusing on the application of machine learning (ML) algorithms for analyzing large amounts of data and identifying complex patterns. The study uses the Scopus, ScienceDirect, and Web of Science databases for bibliometric analysis. ML has become increasingly attractive in engineering due to its ability to improve predictions for process output variables. It is used in chemistry and engineering to improve computational chemistry, plan materials synthesis, and model contaminant remediation processes. The research proposes future research directions for distillery wastewater treatment using ML approaches. The aim of this review is to critically evaluate the application of ML models in wastewater treatment, drawing insights from existing studies and exploring their potential application to distillery wastewater. This study provides comparisons and offers recommendations for future research in this field.
Anticancer Potential of some Plants of Mythological Importance
Authors: Singh Deepika , Dixit Priyanka , Gupta Rajiv 
Published: November 2024

Background:
Cancer is considered one of the leading causes of death internationally, accounting for nearly 10 million deaths in 2020. It was reported that
between 30 and 50% of cancers may be prevented by warding off risk factors and imposing existing proof-based prevention techniques. The cancer
burden can also be reduced through early detection of cancer and appropriate remedies and care for patients who develop most cancers.

Objective:
The objective of the research work is to check out the importance of shortlisted medicinal plants of mythological importance in cancer
management.

Methods:
Michelia champaca and Elaeocarpus ganitrus have been obtained from the BBD Group campus and NBRI Garden, Lucknow, and authenticated
by CSIR Institute NISCAIR (Raw Material & Herbarium Division), New Delhi. Extraction was performed by use of a warm system known as the
Soxhlet extraction method with the utilization of hydroalcoholic solvent, and the plants were further studied for their anticancer activity in various
cancer cell lines, including MCF-7, HeLa, and HepG2 cell lines.

Results:
Phytonutrients are found in both shortlisted plants; Elaeocarpus ganitrus and Michelia champaca are responsible for their medicinal importance.
Both medicinal plants have been investigated for anticancer activity, and it was found that both plants have the capacity to reduce the proliferation
rate and also induce apoptosis of cancer cells.

Conclusion:
Phytochemical analysis of Elaeocarpus ganitrus and Michelia champaca (leaves) extracts were found to have alkaloids, flavonoid content
material, phenolic compounds, and many others., and exceptional antioxidant properties. Ultimately, Elaeocarpus ganitrus and Michelia champaca
have a satisfactory capacity to supply pure antioxidants for livestock, and further relevant research along these lines would be profitable.
Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection
Authors: Hoang Uy , Agrawal Utkarsh , Ordóñez-Mena José Manuel , Marcum Zachary , Radin Jennifer , Araujo Andre , Panozzo Catherine A , Balogh Orsolya , Desai Mihir , Eltayeb Ahreej , Lu Tianyi , Nicodemo Catia , Gu Xinchun , Goudie Rosalind , Fan Xuejuan , Button Elizabeth , Smylie Jessica , Joy Mark , Jamie Gavin , Elson William , Byford Rachel , Madia Joan , Anand Sneha , Ferreira Filipa , Petrou Stavros , Martin David , de Lusignan Simon 
Published: November 2024

Background
There are gaps in our understanding of the clinical characteristics and disease burden of the respiratory syncytial virus (RSV) among community-dwelling adults. This is in part due to a lack of routine testing at the point of care. More data would enhance our assessment of the need for an RSV vaccination program for adults in the United Kingdom.

Objective
This study aimed to implement point-of-care-testing (POCT) in primary care to describe the incidence, clinical presentation, risk factors, and economic burden of RSV among adults presenting with acute respiratory infection.

Methods
We are recruiting up to 3600 patients from at least 21 practices across England to participate in the Royal College of General Practitioners Research Surveillance Centre. Practices are selected if they undertake reference virology sampling for the Royal College of General Practitioners Research Surveillance Centre and had previous experience with respiratory illness studies. Any adult, ≥40 years old, presenting with acute respiratory infection with onset ≤10 days, but without RSV within the past 28 days, will be eligible to participate. We will estimate the incidence proportion of RSV, describe the clinical features, and risk factors of patients with RSV infection, and measure the economic burden of RSV infection.

Results
A total of 25 practices across different English health administrative regions expressed interest and were recruited to participate. We have created and tested an educational program to deploy POCT for RSV in primary care. In addition to using the POCT device, we provide suggestions about how to integrate POCT into primary care workflow and templates for high-quality data recording of diagnosis, symptoms, and signs. In the 2023-2024 winter RSV detection in the sentinel network grew between October and late November. According to data from the UK Health Security Agency, the peak RSV swab positivity was in International Standards Organization week 48, 2023. Data collection remains ongoing, and results from the subset of practices participating in this study are not yet available.

Conclusions
This study will provide data on the RSV incidence in the community as well as rapid information to inform sentinel surveillance and vaccination programs. This information could potentially improve clinical decision-making.

International Registered Report Identifier (IRRID)
DERR1-10.2196/60669
Vitamin B12 and diabetic neuropathies
Authors: Serhiyenko V.A. , Markevych M.-Y. , Sehin V.B. , Serhiyenko A.A. 
Published: November 2024

Vitamin B12 (cyanocobalamin, cobalamin) is an essential cofactor in two important biochemical pathways: methylmalonic acid metabolism and methionine synthesis from homocysteine. In addition to hematologic abnormalities (megaloblastic anemia or even pancytopenia), cobalamin deficiency can cause neurologic symptoms similar to diabetic neuropathy (DN). The underlying molecular mechanisms of DN are still unclear. Most studies have identified the contribution of low-grade chronic inflammation (LGCI) and oxidative stress (OS) to the development of DN. Immunohistochemical studies of calf muscle nerve biopsies obtained from patients with diabetes mellitus and DN indicate activation of the LGCI pathway caused by increased levels of advanced glycation end products, which leads to increased OS. Similar results were found in patients with vitamin B12 deficiency. Thus, clinical changes in patients with DN may be caused by cellular cobalamin deficiency. In vitro and in vivo studies have demonstrated that vitamin B12 has intrinsic antioxidant activity. Thus, cobalamin, regardless of its classical function as a cofactor, can act as an intracellular, in particular intramitochondrial, antioxidant. This may serve as a rationale for the use of vitamin B12 in the treatment of DN, even in the early subclinical stages. The purpose of this review was to discuss the role of vitamin B12 in the prevention and treatment of DN, as well as to analyze new trends and directions for future research. The search was conducted in Scopus, Science Direct (from Elsevier) and PubMed, including MEDLINE databases. The keywords used were vitamin B12, cobalamin, diabetes mellitus, neuropathy, cardiac autonomic neuropathy. A manual search of the bibliography of publications was used to identify study results that could not be found during the online search.
Research on the Strategies for Choosing Employment and Entrepreneurship among Graduates Majoring in Advertising Design (Staying in the Province)
Authors: Xuebo Yu , Wenge Zhang 
Published: November 2024

As the old industrial base of Northeast China, the three northeastern provinces have created brilliance in the development of the national economy. Jilin Province plays a decisive role in the hinterland of the three provinces. The current economy is declining compared to before, and population loss has caused great uncertainty for the local economy. The employment and entrepreneurship of advertising design graduates in the province can directly reflect the impact of local economy, policies, enterprises, talents and other aspects. Studying the employment and entrepreneurship strategies major in the province will play a role in attracting talents, investment and economic development.
Biogenic dietary promoters in aquaculture: nature-based solutions for enhancing growth, health, and sustainability
Authors: Vijayaram Srirengaraj , Mahendran Karthikeyan , Ringø Einar , Razafindralambo Hary , Kannan Suruli , Sun Yun Zhang 
Published: November 2024

Abstract
Aquaculture, as a rapidly expanding global industry, is increasingly challenged by both infectious and non-infectious diseases, posing significant threats to fish health and production. Traditional interventions, such as antibiotics and vaccines, though effective, raise concerns regarding environmental impact and the potential for resistance development. This review explores the promising role of dietary biogenic promoter supplements as an innovative, sustainable alternative for aquaculture. By analysing emerging literature, we highlight the significance of these nature-based solutions, which offer cost-effective, non-toxic, and eco-friendly options to enhance aquaculture productivity. Biogenic supplements, derived from herbs, beneficial microbes, insects, nutrients, bioactive molecules, and nanoparticles, have shown potential in improving feed quality, promoting growth, boosting disease resistance, enhancing immune system function, and supporting overall health in aquatic species. This comprehensive review demonstrates the efficacy of biogenic-mediated supplements in fostering aquaculture sustainability by minimizing the need for traditional chemical interventions. Furthermore, the analysis identifies critical research gaps, particularly in determining optimal supplement concentrations and their species-specific effects. Additionally, large-scale field trials are recommended to validate laboratory findings and assess their practical applications in real-world settings. By synthesizing current research, this review provides valuable insights into the future trajectory of aquaculture practices, positioning biogenic dietary supplements as key contributors to sustainable and efficient aquaculture development.
Saga of anthelmintic resistance: mechanisms of development, methods of detection and ways of mitigation
Authors: Pramanik Antora , Anisuzzaman  , Islam Purba , Sachi Sabbya , Zahorul Islam Md. , Shohana Nusrat Nowrin , Rafiq Kazi 
Published: November 2024

Abstract
Nowadays, antimicrobial resistance is a burning issue all over the globe and has been addressed with higher priority. Anthelmintic resistance (AhR) is also becoming a threatening issue since control of helminths mainly depends on deworming using anthelmintics. Therefore, anthelmintics are frequently used around the year. However, the issue regarding AhR has not been focused properly when compared with anti-microbial resistance (AMR). The occurrence of AhR in livestock is very common and increasing rapidly. There are lots of evidences of AhR developed against various anthelmintics. The intensive and indiscriminate use of anthelmintics like benzimidazoles (BMZ), tetrahydropyrimidines (THP) and macrocyclic lactones (MCL) has led to the development of AhR. Therefore, researchers should devise and implement new strategies for helminth control, and control should increasingly incorporate alternative and evidence-based control strategies to limit the development of AhR. This review describes the mechanism of AhR, recent advances in developing resistance, diagnostic tests and worm control strategies.
Turning Research of a Sowing Unit Based on Reversible Tractor
Authors: Findura Pavol , Kollárová Katarína , Nadykto Volodymyr , Kyurchev Volodymyr , Zhokin Ivan 
Published: November 2024

Abstract
Modern sowing machine-tractor units (MTU) can be divided into single-machine (single-module), two-machine (double-module), and three-machine (triple-module). The firsts, consisting of a tractor and a trailed/mounted seeder, are the most studied and, therefore, the most widespread. Two-module MTUs mainly use trailed or semi-mounted hitch and trailed seeders. The units of this type have been studied less. Three-module sowing complexes are even less common. Most are based on a trailed hitch and trailed seeders placed behind the tractor. There are samples of MTU with side-mounted seeding machines, but their knowledge is extremely insufficient. This paper examines a three-module MTU based on a tractor with reverse motion and a front semi-mounted hitch. One of the problems in using this sowing unit is the choice of design parameters that would ensure safe turning when manoeuvring on the headland. Theoretical and experimental studies have established that by increasing the side seeder’s towbar length, MTU’s safe turning under analysis with machines of a larger operating width can be performed with a smaller distance between their inner wheels and tractor’s wheels (parameter d). If the coincidence condition of side seeders’ wheel axes with the tractor wheels axe is met, an increase in the tractor track from 1.7 to 2.5 m allows for a decrease in the value of the distance d. This solution is especially effective when using seeders with an operating width of 3.6 m. In this case, the indicated decrease reaches a fivefold size, from 0.5 to 0.10 m. With the seeders’ operating width of 5.4 m, the distance d can only be reduced by 1.4 times. But with this option for sowing MTU, it is possible to use a tractor with dual rear tyres and a parameter d value of 0.98 m. Actual oscillations in the distance d value within 0.28 ±0.01 m in the process of turning the studied sowing machine-tractor unit at a velocity of 2.2 m·s−1 are characterized by low variance (0.64·10−4 m2) and low (no more than 1.75 Hz) frequency. This allows us to consider this MTU’s mode movement on the headland quite safe.
Determination of Extra Virgin Olive Oil Adulteration Using Laser Induced Fluorometry – Chlorophyll Relative Intensity Method
Authors: Kosor Tihomir , Morosavljević Ivan , Nakić-Alfirević Barbara , Morosavljević Janko , Kozak Dražan , Drlička Róbert 
Published: November 2024

Abstract
A new method has been proposed for detecting the potential adulteration of extra virgin olive oil with processed sunflower oil. This method is based on analysing the laser-induced fluorescence (LIF) spectra of samples. The technique involves measuring the intensity ratio of three specific fluorescence peaks within the 650–750 nm region of the spectra, which are attributed to chlorophyll derivatives. The samples are excited with a 460 nm blue laser in an offset configuration. The results obtained indicate that the relative intensity ratio of these characteristic chlorophyll peaks is consistently correlated with the percentage of oil adulteration. A parameter named the chlorophyll relative intensity (CRI) number has been introduced, which is based on the relative intensity ratios of the chlorophyll peaks in the LIF spectra of the extra virgin olive oil sample. The CRI function demonstrates a linear relationship with the adulteration percentage up to 80%, with a high regression coefficient (R
2) value of 0.9984. This method can be applied accurately when the original fluorescence spectra of unadulterated extra virgin olive oil are known, and it can provide valuable information about the source of unknown oil samples.
Development of Power Supply System Solar Base for Coffee Pulper
Authors: Iqbal  , Ferialdi  , Paliling Agil Ricky , Azis Abdul , Mursalim  , Achmad Mahmud , Waris Abdul , Hardinasinta Gemala , Mubarak Husnul , Hati Febriana Intan Permata , Rizal Muhammad 
Published: November 2024

Abstract
Coffee pulpers generally use combustion and electric engines in operation, which have many disadvantages such as expensive fuel, pollution, and limited usage in places where electricity is supplied by the government. Therefore, a wet pulper coffee powered by an alternating current electric engine based on solar panels was developed. This study aims to produce and test a solar-powered alternating current electric engine wet pulper for coffee. This research went through several stages which are collecting secondary data, designing the tools to be developed, technical analysis, and performance test. The development of the pulper machine included an electric motor with a power of 1103.64 W, with a maximum machine rotational speed of 1400 rpm, an inverter, a 12 V and 100 A battery, a solar panel, and a 24 A solar charge controller. The performance results showed a stripping capacity of 783.176 kg∙h−1 and the best percentage of stripped coffee pulp at a machine rotational speed of 467 rpm and a mass of 3 kg. The findings show that a pulper powered by a solar-based alternating current electric engine can be a viable solution for areas without electricity and a suitable replacement for combustion engines.
Towards AI Copyright Equilibrium
Authors: Dermawan Artha 
Published: November 2024

Abstract
To balance generative AI (GenAI) innovation with the protection of copyright for authors and performers, it is necessary to recalibrate the concept of “public interest.” This recalibration is crucial to ensure that authors and performers receive fair and equitable remuneration for their contributions while facilitating public access to knowledge and cultural expressions. Such a redefinition is also aimed at addressing current challenges, including fair use, open access, and the democratization of information within the AI industry. Drawing on Virginia Held’s typology of public interest theory, this article suggests that adjustments to the notion of public interest should include establishing a balance through either a majority of individual interests or empirical data; aligning with the collective interests that receive societal endorsement; and evaluating public interest based on normative content and moral judgment, utilizing the principle of enjoyment and the public perception test in copyright law. While various theoretical frameworks could be used to conceptualize public interest, the article proposes an approach that explicitly defines copyright objectives and harmonizes the rights of authors and performers with the public’s right to access creative works. Such harmonization could be achieved through an integrative methodology that combines evidence-based analysis, consensus among stakeholders without conflicting interests, and normative evaluations rooted in societal ethics.