bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of uncoordinated sucking pattern with developmental outcome in premature infants: a retrospective analysis
Authors: Yi You Gyoung , Oh Byung-Mo , Shin Seung Han , Shin Jin Yong , Kim Ee-Kyung , Shin Hyung-Ik 
Published: September 2019

Abstract
Background Stress signals during sucking activity such as nasal flaring, head turning, and extraneous movements of the body have been attributed to incoordination of sucking, swallowing, and respiration (SSR) in premature infants. However, the association of uncoordinated sucking pattern with developmental outcomes has not yet been investigated. The aim of this study was to investigate whether uncoordinated sucking pattern during bottle-feeding in premature infants is associated with the developmental outcomes at 8-12 and 18-24 months of age (corrected for prematurity).Methods We retrospectively reviewed the medical records and video recordings for the Neonatal Oral-Motor Assessment Scale (NOMAS) of premature infants and divided them into two groups based on the presence or absence of incoordination. The Bayley-III cognition composite scores of the incoordination-positive and incoordination-negative group were compared at 8-12 and 18-24 months of age.Results Seventy premature infants exhibited a disorganized sucking pattern according to the NOMAS. The average Bayley-III cognition composite scores at 8-12 months of age were 92.5±15.6 and 103.0±11.3 for the incoordination-positive (n=22) and incoordination-negative groups (n=48), respectively (p=0.002). The average Bayley-III cognition composite scores at 18-24 months were 90.0±17.9 and 100.7±11.5 for the incoordination-positive (n=21) and incoordination-negative groups (n=46), respectively (p=0.005). A multiple linear regression analysis indicated that the presence of uncoordinated sucking pattern, grade 3 or 4 germinal matrix hemorrhage–intraventricular hemorrhage, and moderate to severe bronchopulmonary dysplasia were independently associated with cognitive development at 18-24 months of age.Conclusions Uncoordinated sucking pattern in premature infants is associated with developmental delay in the cognitive domain of the Bayley-III at both 8-12 and 18-24 months. There may be a need for periodic follow-up and early intervention for developmental delay when incoordination of SSR that results in stress signals on the NOMAS is observed before 40 weeks postmenstrual age.
Premarital sexual practice and its associated factors in Ethiopia. A systematic review and meta-analysis
Authors: Getaneh Temesgen , Negesse Ayenew , Chane Jemberu 
Published: September 2019

Abstract
Background Globally, large numbers of adolescents engage in premarital sexual practice. Youths who begin early sexual activity are more likely to be exposed for high-risk of having multiple sexual partners, infection with Human Immune Deficiency Virus (HIV) and other sexual transmitted diseases. There are pocket studies which reported meager and fragmented evidences across different parts of Ethiopia related with this issue, hence the aim of this review was also to estimate those meager evidences and come up with concrete information at the national level.Methods articles were retrived through search engines such as: PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, HINARI portal, and Cochrane Library using the preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for critical appraisal of the included articles. Random effect model analysis technique was considered to estimate the pooled prevalence of premarital sexual practice with their respective odds ratio (OR) and 95% confidence interval (CI). Cochran’s Q statistic, Egger’s and Begg’s test and meta regression were carried out to assess heterogeneity, publication bias and to identify associated factors respectively.Results Exactly 24 articles with total sample size 14,872 individuals were included for this review. The pooled estimate of premarital sexual practice at the national level was 30.98% (95% CI: 26.74, 35.21). Being female sex (OR=1.55: 95% CI; 1.01, 2.37), age >18yrs (OR=2.39: 95% CI; 1.29, 4.42), being alcohol abuser with (OR=3.47; 95% CI; 1.94, 6.19) and exposed to pornography (OR=3.24:95% CI; 1.95, 5.38) were the associated factors of premarital sexual practice in Ethiopia.Conclusion The pooled prevalence of premarital sexual practice in Ethiopia was high in comparison with other countries. So that it is the strong recommendations of the authors’ to provide an integrated youth’s reproductive and sexual health services on the local context to decrease their exposure for premarital sexual practices and its negative impact on future life opportunities. Keywords: Pooled; Premarital; Sexual; Practice; Prevalence; Ethiopia .
Establishment of a type 1 diabetes structured education programme suitable for Chinese patients: Type 1 Diabetes Education in Lifestyle and Self Adjustment (TELSA)
Authors: Xie Yuting , Liu Fang , Huang Fansu , Lan Chunna , Guo Jia , He Jing , Li Lezhi , Li Xia , Zhou Zhiguang 
Published: September 2019

Abstract
Background It is recommended by various guidelines that all adults diagnosed with type 1 diabetes (T1D) should be offered an evidence based, structured education programme (SEP) to optimize self-management care. China has a 13,000 annual increase of newly diagnosed T1D cases and is now the fourth largest country in the number of new T1D cases per year. However, there is yet no validated SEP targeted for T1D patients in China. The purpose of this paper is to establish a structured T1D self-management education programme—‘Type 1 Diabetes Education in Lifestyle and Self Adjustment’ (TELSA) which adapted to China’s medical and cultural background.
Methods The process of developing the programme TELSA was based on the ADDIE model by three steps. Firstly, semi-structured interviews were conducted in 10 healthcare professionals (HCPs) and 13 T1D patients. Different topic guides, focusing on 4 dimensions including goals, contents, format of delivery, and quality assurance, were designed for either HCPs or patients. The interviews were recorded and analysed with thematic analysis. Secondly, extracted themes were modified according to Delphi consultation. Lastly, preliminary courses were conducted as pilot study to evaluate the effects of TELSA and optimization of the curriculum design was finalized accordingly.
Results A total of 18 themes in 4 dimensions of the programme design were identified in the final version: i) goals: ‘behaviour modification’ and ‘outcome improvement’; ii) contents: ‘living with T1D’, ‘self-monitoring of blood glucose’, ‘knowing insulin’, ‘insulin dose adjustment’, ‘carbohydrates and carb-counting’, ‘hypoglycaemia’, ‘complications’, ‘managing psychological issues’, ‘physical activities’, and ‘question-and-answer’; iii) format: ‘multidisciplinary team combined with companion support’, ‘face-to-face education followed with distal learning’, and ‘2-day programme held on weekends’; and iv) quality assurance: ‘after-class quiz’, ‘patients’ feedbacks’, and ‘long-term evaluation on effectiveness’.
Conclusions A type 1 diabetes structured education programme in China was set up and shown to be applicable under local medical, social, and cultural environment.
Depression and neuroticism in patients with peripheral arterial disease: a cross-sectional study
Authors: Tóth-Vajna Gergely , Tóth-Vajna Zsombor , Balog Piroska , Thege Barna Konkolÿ 
Published: September 2019

Abstract
Background: The aim of this study was to examine the relationship of depressive symptomatology and personality traits with peripheral arterial disease (PAD). Methods: The sample comprised of 300 individuals (Mage=65.3±8.7 years, 61.0% female) recruited from the offices of 33 general practitioners. Based on at-rest ankle-brachial index (ABI) values and claudication symptoms, four subsamples were formed: clear PAD-positive, clear PAD-negative, ABI-negative but symptomatic, and a non-compressible-artery group. The concurrent role of depression (assessed by a shortened version of the Beck Depression Inventory), and five-factor personality traits (measured with the Big Five Inventory) in predicting PAD status was examined using multinomial logistic regression analysis – controlled for sex, age, hypertonia, diabetes, smoking, hazardous drinking, and body mass index. Results: Depressive symptomatology was significant in predicting peripheral arterial disease status even after controlling for both traditional risk factors and personality traits. Among the Big Five personality traits, neuroticism showed the most consistent relationship with PAD – independently of depression. Conclusions: Patients with PAD – even those with asymptomatic forms of the disease – are at higher risk for suffering from depression compared to individuals without PAD, independently of neuroticism, other Big Five personality dimensions or traditional risk factors for cardiovascular diseases.
Occupational hazards in medium and large scale industrial sectors in Sri Lanka – Experience of a developing country
Authors: Arnold S.M. , Wickrematilake MSK , Fernando RMSD , Sampath HMRC , Karunapema RPP , Mahesh PKB , Munasinghe PM , Denawaka CJ 
Published: September 2019

Abstract
Objective Occupational hazards is an area where many countries have begun to pay more emphasis as it affects the health of many particularly in developing countries. However, documented literature is scarce in this regard although occupational hazards are common in workplaces. The study was carried out with the objective of describing the physical hazards and control measures adopted in the formal medium and large-scale industrial sector in Sri Lanka . Results Physical hazards detected in the workplaces were; excessive noise (78.3%), poor light (58%), increased temperature (65.2%), and poor ventilation (68.1%). Over 50% of large machinery and 33% of medium-scale machinery were not adequately guarded. Nearly 41% of the machinery were difficult to operate, of them 36.2% had controls in positions which were hard to reach. Of safety measures adopted, only 34.8% had proper demarcation of areas with 28.9% displaying safety signs. Housekeeping was poor in 59.4% and less than 40% had safe storage of raw materials and end products. Key words Occupational hazards, Occupational health, Hazard control, Industry
Long-lasting severe immune dysfunction in Ebola virus disease survivors
Authors: Wiedemann Aurélie , Foucat M.Sc. Emile , Hocini Hakim , Lefebvre M.Sc. Cécile , Keita Alpha Kabinet , Ayouba Ahidjo , Mély M.Sc. Stéphane , Fernandez M.Sc. José-Carlos , Tou Abdoulaye , Lévy-Marchal Claire , Raoul Hervé , Delaporte Eric , Koivogui Lamine , Lacabaratz Christine , Lévy Yves 
Published: September 2019

Abstract
Clinical follow-up of Ebola virus disease (EVD) survivors revealed a persistence of clinical symptoms and higher risk of mortality. Long-term analyses of the immune and inflammatory profiles of EVD survivors are currently lacking. Here, we evaluate immune profile status and gene expression profiles in 35 Guinean EVD survivors (EBOV_S) from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from the Ebola treatment center. We show a persistent increase of several biomarkers of inflammation, immune activation and gut tissue damage in EBOV_S compared to healthy donors living in the same area. These results are confirmed by phenotypic characterization of immune cell subsets revealing increases in activation marker expression and the frequencies of CD8+ T cells, exhausted B cells, non-classical NK cells and circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing studies of the genes expressed in blood revealed a significant enrichment in genes associated with antiviral responses in EBOV_S. This study assess the long-term persistence of immunological dysfunction in survivors and identify a set of biological and genetic markers that could be used to define a signature of “chronic Ebola virus disease (CEVD)”.
Australia's water efficiency labelling and standards scheme: summary of an environmental and economic evaluation
Authors: Fane S. , Grossman C. , Schlunke A. 
Published: September 2019

Abstract
This paper describes the outcomes of an evaluation of Australia's Water Efficiency Labelling and Standards (WELS) scheme. WELS is a national, government-run scheme that mandates water efficiency labelling for indoor water-using fixtures and appliances. The scheme also imposes a minimum standard for some products. The evaluation considered the environmental and economic impacts of improvements in the water efficiency of WELS-labelled products since the scheme's inception in 2006 and forecast for 20 years. The study estimated water, energy, greenhouse gas (GHG) and utility bill savings as well as the costs associated with the scheme. The evaluation showed WELS to be an important component of urban water management in Australia, saving 112 GL in 2017–18, across the country, and 231 GL/year by 2036–37. The largest economic benefits of WELS came from the energy saving from reduced water heating. Over 30 years, these energy savings are also expected to reduce GHG emissions by a cumulative 53.5 Mt. On average, Australians saved $A42 (US$30) per person per year in 2017–18 due to the water efficiency driven by WELS. Overall, the evaluation shows the WELS scheme to be highly beneficial for Australia with significant net benefits to the present and projected into the future.
New Insights into Apolipoprotein A5 and the Modulation of Human Adipose-derived Mesenchymal Stem Cells Adipogenesis
Authors: Su Xin , Weng Shuwei , Peng Daoquan 
Published: September 2019

Background:
The hallmark of obesity is the excessive accumulation of
triglyceride (TG) in adipose tissue. Apolipoprotein A5 (ApoA5) has been shown to
influence the prevalence and pathogenesis of obesity. However, the underlying
mechanisms remain to be clarified.

Methods:
Human adipose-derived mesenchymal stem cells (AMSCs) were treated with
600 ng/ml human recombinant ApoA5 protein. The effect of ApoA5 on intracellular TG
content and adipogenic related factors expression were determined. Furthermore, the
effect of ApoA5 on CIDE-C expression was also observed.

Results:
During the process of adipogenesis, ApoA5 treatment reduced the intracellular
accumulation of lipid droplets and the TG levels; meanwhile, ApoA5 down-regulated the
expression levels of adipogenic related factors, including CCAAT enhancer-binding
proteins α/β (C/EBPα/β), fatty acid synthetase (FAS), and fatty acid-binding protein 4
(FABP4). Furthermore, the suppression of adipogenesis by ApoA5 was mediated
through the inhibition of CIDE-C expression, an important factor which promotes the
process of adipogenesis. However, over-expressing intracellular CIDE-C could lead to
the loss-of-function of ApoA5 in inhibiting AMSCs adipogenesis.

Conclusions:
In conclusion, ApoA5 inhibits the adipogenic process of AMSCs through,
at least partly, down-regulating CIDE-C expression. The present study provides novel
mechanisms whereby ApoA5 prevents obesity via AMSCs in humans.
Integrase Inhibitor-Based Antiretroviral Therapy Among Women Living with HIV: Data from the OPERA Cohort
Authors: Fusco Jennifer , Henegar Cassidy , Quinlivan Evelyn Byrd , Vannappagari Vani , Aboud Michael , Smith Kimberly , Fusco Gregory 
Published: September 2019

Background:Women face unique complexities in HIV treatment yet are underrepresented in antiretroviral therapy (ART) studies.Objective:This analysis assessed the one-year durability of the first integrase strand transfer inhibitor (INSTI)-based regimens prescribed to women in a large cohort of patients living with HIV in care.Methods:Women with HIV who initiated their first INSTI-containing regimen between 08/12/2013 and 11/30/2015 were identified in the OPERA cohort, a collaboration of 79 US outpatient clinics. Discontinuation within the first year of treatment with an INSTI was compared between dolutegravir (DTG), raltegravir (RAL) and elvitegravir (EVG), using multivariable Cox regression and Kaplan- Meier estimates. Virologic response and regimen modifications were described and compared across INSTIs.Results:A total of 537 treatment-naïve (DTG: 39%, EVG: 48%, RAL: 13%) and 878 treatmentexperienced (DTG: 57%, EVG: 29%, RAL: 13%) women were analyzed. In the first twelve months after initiation, women taking EVG or RAL were more likely to discontinue their initial INSTI than those taking DTG among both treatment-naïve (adjusted hazard ratio EVG vs. DTG: 1.59 (95% CI: 1.09, 2.39); RAL vs. DTG: 2.46 (1.49, 4.05)) and treatment-experienced women (EVG vs. DTG: 1.39 (1.02, 1.88); RAL vs. DTG: 2.17 (1.51, 3.12)). Following discontinuation of the initial INSTI, women commonly switched to a regimen containing a different drug from the INSTI class (treatment-naïve DTG: 34%, RAL: 33% EVG: 41%; treatment-experienced DTG: 23%, RAL: 19% EVG: 41%).Conclusion:In treatment-naïve and treatment-experienced women living with HIV, women taking DTG had the lowest risk for early (≤1 year) discontinuation.
Religiusitas dan stres pengasuhan pada ibu dengan anak autis
Authors: Rahayu Ainur Titis Dwi , Ni'matuzahroh Ni'matuzahroh , Amalia Sofa 
Published: September 2019

Abstrak. Seorang ibu yang memiliki anak dengan gangguan autis biasanya mengalami stres pengasuhan yang berasal dari tuntutan perannya sebagai orangtua. Stres pengasuhan akan terjadi dikarenakan kurangnya pemahaman orangtua terkait gangguan anak, sulitnya perilaku anak untuk dikendalikan dan ketidakberfungsiannya interaksi antara ibu dengan anaknya. Sementara itu, religiusitas dapat membantu para ibu untuk mengelola stres yang dialami. Tujuan dari penelitian ini adalah untuk menguji hubungan antara variabel religiusitas dengan stres pengasuhan ibu yang memiliki anak autis. Penelitian ini merupakan penelitian kuantitatif korelasional dengan 60 subjek dan menggunakan teknik quota sampling. Alat ukur yang digunakan untuk mengukur variabel religiusitas adalah skala religiusitas sedangkan variabel stres pengasuhan menggunakan alat ukur parenting stress index (PSI). Teknik analisa data yang digunakan adalah korelasi pearson product moment dengan program spss 21.0. Hasil penelitian ini menunjukkan adanya hubungan negatif antara religiusitas dengan stres pengasuhan dengan nilai signifikasi <0.05 dan koefisien korelasi -0.446.Kata kunci: autis, religiusitas, stres pengasuhan Abstract. A mother who has a child with autistic disorder usually experience parenting stress from the demands of his role as a parent. Parenting stress will occur due to lack of parental understanding of child-related disorders, the difficulty of the child's behavior to be controlled and non-functioning of the interaction between a mother with her child. Meanwhile, religiosity can help mothers to manage the stress experienced. The purpose of this study was to examine the negative correlation between religiosity variable with parenting stress mothers of children with autism. This research is a quantitative correlation with 60 subjects and using a quota sampling technique. Measuring instrument used to measure the variables religiosity is the religiosity scale Kendler, et al while parenting stress variable using a measuring instrument parenting stress index (PSI). Data analysis technique used is the Pearson product moment correlation with SPSS 21.0 program. The results of this study showed a negative relationship between religiosity and parenting stress the significance value of <0.05 and a correlation coefficient of -0446.Keywords: autism, religiosity, parenting stress
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells
Authors: Inshaw Jamie R.J. , Cutler Antony J. , Crouch Daniel J.M. , Wicker Linda S. , Todd John A. 
Published: September 2019

OBJECTIVE
Immunohistological analyses of pancreata from patients with type 1 diabetes suggest distinct autoimmune islet β-cell pathology between those diagnosed at &lt;7 years (&lt;7 group) and those diagnosed at age ≥13 years (≥13 group), with both B- and T-lymphocyte islet inflammation common in children in the &lt;7 group, whereas B cells are rare in the ≥13 group. Based on these observations, we sought to identify differences in genetic susceptibility between these prespecified age-at-diagnosis groups to inform on the etiology of the most aggressive form of type 1 diabetes that initiates in the first years of life.

RESEARCH DESIGN AND METHODS
Using multinomial logistic regression models, we tested if known type 1 diabetes loci (17 within the HLA and 55 non-HLA loci) had significantly stronger effect sizes in the &lt;7 group compared with the ≥13 group, using genotype data from 27,071 individuals (18,485 control subjects and 3,121 case subjects diagnosed at &lt;7 years, 3,757 at 7–13 years, and 1,708 at ≥13 years).

RESULTS
Six HLA haplotypes/classical alleles and six non-HLA regions, one of which functions specifically in β-cells (GLIS3) and the other five likely affecting key T-cell (IL2RA, IL10, IKZF3, and THEMIS), thymus (THEMIS), and B-cell development/functions (IKZF3 and IL10) or in both immune and β-cells (CTSH), showed evidence for stronger effects in the &lt;7 group.

CONCLUSIONS
A subset of type 1 diabetes–associated variants are more prevalent in children diagnosed under the age of 7 years and are near candidate genes that act in both pancreatic β- and immune cells.
Prospective Study of Neuropathic Symptoms Preceding Clinically Diagnosed Diabetic Polyneuropathy: ADDITION-Denmark
Authors: Määttä Laura L. , Charles Morten , Witte Daniel R. , Bjerg Lasse , Jørgensen Marit E. , Jensen Troels S. , Andersen Signe T. 
Published: September 2019

OBJECTIVE
To evaluate whether diabetic polyneuropathy (DPN) follows the hypothesis for the course of nerve fiber damage reflected by symptoms progressing from pure small through mixed to large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers.

RESEARCH DESIGN AND METHODS
Repeated assessments of nerve fiber–specific symptoms were obtained in 518 participants of the ADDITION-Denmark study from the time of a screening-based diagnosis of type 2 diabetes using specific items of the Michigan Neuropathy Screening Instrument questionnaire. DPN was clinically assessed 13 years after inclusion. The course of symptoms reflecting dysfunction of specific nerve fibers was evaluated, and the association between symptoms and DPN was estimated using logistic regression models.

RESULTS
An overall stable, yet heterogeneous course of symptoms was seen. According to the hypothesis of symptom progression, 205 (40%) participants remained free of symptoms and 56 (11%) had stable, 114 (23%) progressing, and 132 (26%) improving symptoms. Cross-sectional estimates showed a higher risk of DPN (odds ratios between 2.1 and 4.1) for participants with mixed or large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers compared with participants without symptoms.

CONCLUSIONS
There was no evidence for a progressive development of nerve fiber damage in DPN reflected by symptoms going from pure small through mixed to large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers. Yet overall, neuropathic symptoms were prospectively associated with a higher risk of DPN.