bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential quantitative proteomics reveals the functional difference of two yigP locus products, UbiJ and EsrE
Authors: Tang Qiongwei , Feng Meilin , Xia Hui , Zhao Yiming , Hou Bingbing , Ye Jiang , Wu Haizhen , Zhang Huizhan 
Published: September 2019

AbstractThe yigP (ubiJ) locus has been shown to be associated with many phenotypic changes in Escherichia coli, while the individual function of its two products, EsrE small RNA and UbiJ protein, is still elusive. In this study, we constructed two single‐element mutants, EsrE mutant strain Mut and UbiJ mutant strain Ter, on the basis of the base substitution programs. The variable antibiotics resistance and ubiquinone (UQ, coenzyme Q) yield and the similar cell growth between mutants revealed the division of labor and collaboration of EsrE and UbiJ in JM83. Furthermore, we detected the concentration of intracellular proteins of Mut and Ter by stable isotope‐labeled quantitative proteomics. The results demonstrate that both EsrE and UbiJ are involved in the aerobic growth of E. coli, while EsrE preferentially contributes to the amino acid‐related pathway, and UbiJ is an indispensable factor in the biosynthesis of UQ. Moreover, we uncovered a potential regulatory circuit of
d‐cycloserine (DCS) that composed of EsrE, GcvA, and GcvB by proteomic analysis.
A Biocompatible Multilayer Film from an Asymmetric Picolinium‐Containing Polycation with Fast Visible‐Light/NIR‐Degradability
Authors: Zhang Hanzhi , Zhou Tongtong , Shen Jiwei , Zhang Ping , Chen Xin , Chen Yongming , Yu You 
Published: September 2019

AbstractFinely tuning the photodegradation behavior of the layer‐by‐layer (LbL) film from the view of controlling the chemical structure of the film‐building polymer is still a challenge in related fields. To meet this requirement, a photodegradable polymer (P1) is rationally designed for assembling a visible‐light‐degradable multilayer film with polystyrene sulfonate (PSS). Compared with similar photopolymers (P2 and P3), this asymmetric picolinium‐containing polymer can significantly enhance the degradation rate of as‐prepared LbL films; under the same degradation condition, the degradation rate of (P1/PSS)10 is 3 and 6.6 times that of (P2/PSS)10 and (P3/PSS)10, respectively. Moreover, near‐infrared light (NIR) is available for triggering the degradation of this film with the assistance of upconversion nanoparticles of YbTm@Lu. The cell cytotoxicity and cell proliferation experiments reveal that P1 is nontoxic and favorable for cell proliferation at concentrations of up to 500 μg mL−1. As for (PSS/P1)10 films, the ratio of cell number of these two samples ((PSS/P1)10 modified: photodegraded) increases dramatically and reaches about 1.67:1 after 72 h incubation. On the basis of these results, it is anticipated that P1 and this LbL film is an exceptional candidate for visible‐light/NIR degradable materials in materials and biological science, medicine, and optics.
Catalytically Selective Chemotherapy from Tumor‐Metabolic Generated Lactic Acid
Authors: Tian Zhimin , Yang Kaili , Yao Tianzhu , Li Xuhui , Ma Yuanyuan , Qu Chaoyi , Qu Xiaoli , Xu Yujing , Guo Yinhui , Qu Yongquan 
Published: September 2019

AbstractLactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments (TMEs). Inspired by its high intratumoral level (5–20 µmol g−1), a novel treatment paradigm via the cascade release of H2O2 and ·OH from the LA generated by tumor metabolism is developed for catalytic and pH‐dependent selective tumor chemotherapy. By utilizing the acidity and overexpression of LA within the TME, the constructed lactate oxidase (LOD)‐immobilized Ce‐benzenetricarboxylic acid (Ce‐BTC) metal organic framework enables the intratumoral generation of ·OH via a cascade reaction: 1) the in situ catalytic release of H2O2 from LA by LOD, and 2) the catalytic production of ·OH from H2O2 by Ce‐BTC with peroxidase‐like activity. Highly toxic ·OH effectively induces tumor apoptosis/death. A new strategy for selective tumor chemotherapy is provided herein.
Vitellogenin and vitellogenin-like gene expression patterns in relation to caste and task in the ant Formica fusca
Authors: Morandin C. , Hietala A. , Helanterä H. 
Published: September 2019

AbstractSocial insect colonies are characterized by division of labour, and extensive morphological, physiological and behavioural differences between queens and workers. The storage protein vitellogenin (Vg) affects multiple aspects of social insect life histories, and has been suggested as a key player for caste differentiation and maintenance. Recently, three genes homologous to Vg have been described in the antFormica exsecta. Their role is currently unclear but their structural variation suggests variable functions. We examined the expression patterns of the conventional Vg and the three Vg-like genes using qRT-PCR in the common black antFormica fuscabetween queens and workers, between nurse and foragers workers, and across social contexts (queenless vs. queenright nests), and sampling time. As expected, we found a significant queen caste and nurse task-related increase for the conventional Vg, while Vg-like-C displayed a consistent forager-biased expression pattern. Task (forager vs. nurse) was the only factor that explained expression variation among workers in any of the studied genes. The removal of the queen did not affect expression, although the proportion of fertile nurses increased in queenless nests. The observed expression biases suggest that inFormica fusca,the ancestral duplication has led to alternative social functions for Vg-like genes across castes and tasks. To get a broader picture of the role of gene duplications in social evolution and the roles of Vg-like genes in caste differentiation and maintenance, how these genes achieve these roles at a molecular level need to be investigated further.
Superior knee self-efficacy and quality of life throughout the first year in patients who recover symmetrical muscle function after ACL reconstruction
Authors: Piussi Ramana , Beischer Susanne , Thomeé Roland , Hamrin Senorski Eric 
Published: September 2019

AbstractPurposeThe aim of this study was to (1) describe psychological outcomes during the first year after an anterior cruciate ligament (ACL) reconstruction and (2) compare psychological outcomes in patients who recover symmetrical muscle function with patients who do not.MethodsThe included patients had undergone a unilateral ACL reconstruction. Patients with a re-rupture and contralateral ACL injury were excluded. Three groups, based on the results from 5 tests of muscle function 12 months after reconstruction, were created. Three validated questionnaires (the Knee Self-Efficacy Scale; the Knee injury and Osteoarthritis Outcome Score subscale “Quality of Life”; the ACL Return to Sport after Injury scale) and a single question “Have you achieved your goal with rehabilitation?” were analysed in 4 different follow-ups after ACL reconstruction (10 weeks, 4, 8 and 12 months). Means and standard deviations were analysed with standardttests and reported with 95% confidence intervals.ResultsA total of 328 patients (120 men, 37%), mean age 27.8 ± 10 years, were included. Patients who did not recover symmetrical muscle function (n = 56; 17%) at the 12-month follow-up reported inferior knee-related self-efficacy and quality of life than patients who recovered symmetrical muscle function (n = 96; 29%) at all follow-ups, except quality of life at 4 months. The proportion of patients who stated they achieved their rehabilitation goal at 12 months was 17% for the entire cohort, 24% for patients who recovered muscle function and 5% for patients who did not recover muscle function.ConclusionPatients who recovered strength and hop symmetry 12 months after ACL reconstruction had superior knee-related self-efficacy and greater quality of life during the whole first year after ACL reconstruction. These results can aid clinicians in the decision-making process by providing knowledge of patients who might need further attention during rehabilitation.Level of evidenceIII.
Challenges to Build up a Collaborative Landscape Management (CLM)—Lessons from a Stakeholder Analysis in Germany
Authors: Zscheischler Jana , Busse Maria , Heitepriem Nico 
Published: September 2019

AbstractTraditional cultural landscapes are of special value not only for reasons of nature conservation and high species diversity but also because they intersect with the identity of local communities, support recreation and tourism, and preserve cultural heritage. Structural changes in rural areas threaten these unique sceneries and environments in Europe and worldwide. As a result, the question of how to maintain and manage cultural landscapes where economic benefits are not assured has become a priority in science and in practice. Considering this context, community-based collaborative landscape management (CLM) can be considered an innovative and promising approach. This paper presents results from a stakeholder analysis examining the preconditions and opportunities for initiating a CLM in the biosphere reserve known as ‘Spreewald’. The results indicate that due to the type of problem (landscape change)—which is characterised by complexity, beneficial linkages to a multitude of actor groups, and broad problem awareness—CLM appears to be feasible. However, other preconditions related to social relationships among actor groups, questions of legitimate coordination and the collaborative capacity of the community are not met, thus reducing the likelihood of success. To address these challenges, we discuss the potential of transdisciplinary processes (TD) to assist local communities in establishing such a collaborative problem-solving and management approach. We show that TD is highly valuable and supportive during this critical stage of emerging collaboration.
Characterization of Calcium Homeostasis in Lithium‐Treated Patients Reveals Both Hypercalcaemia and Hypocalcaemia
Authors: Meehan Adrian D. , Wallin Göran , Järhult Johannes 
Published: September 2019

AbstractIntroductionPrevalence studies demonstrate that a significant proportion of lithium‐treated patients develop hypercalcaemia (3–30%). Lithium‐associated hyperparathyroidism (LHPT) is poorly defined, and calcium homeostasis may be affected in a more complicated fashion than purely by elevated PTH secretion. The current study aims to examine in detail calcium homeostasis principally with regard to lithium duration.MethodsMedical records of 297 lithium‐treated patients (193 women, 104 men; median age 58 years) were examined, and information on gender, age, lithium treatment duration and calcium homeostasis was obtained. The median treatment duration with lithium was 16 (1.5–45) years.ResultsA total of 8504 calcium values were retrieved. Before initiation of lithium treatment, serum calcium was on average 2.33 mmol/l (2.02–2.60). During the treatment period, 178 patients (60%) remained normocalcaemic, 102 (34%) developed hypercalcaemia or were strongly suspected of LHPT, 17 (6%) had 3 or more intermittent episodes of hypocalcaemia. Forty‐one per cent of patients with suspected or confirmed LHPT had low (<4 mmol) 24‐h urine calcium levels. The success rate after 33 parathyroidectomies was 35%, hyperplasia being diagnosed in 75% of extirpated glands.ConclusionsThe prevalence of hypercalcaemia during lithium treatment is very high. In addition, hypocalcaemic episodes appear to occur frequently, possibly reflecting a more complicated parathyroid dysfunction than previously known. Long‐term surgical results are unsatisfactory. LHPT biochemical profile is different from that of primary hyperparathyroidism and is in some ways similar to familial hypocalciuric hypercalcaemia.
Contemporary European Normative Tendencies Regarding the Essence and Typology of Insurance Contracts
Authors: Fras Mariusz 
Published: September 2019

AbstractIn the light of different approaches to the question of regulating economic insurance law in specific legal systems, formulation of a model definition of the insurance contract, although necessary for further investigations, is merely theoretical. Specific lawmakers approach the question of specification of the content of the insurance contract at the statutory level with varying degree of consequence. Insurance relationships are a heterogeneous category, and attempts to develop uniform systematics with the use of comparative legal methods are still hindered by differences between individual legal systems. There is a lack of consistence between the distinctions adopted in private law systems and solutions characteristic of public law, which exert much influence on the market of insurance services as a part of insurance supervision.
A Self Interference Nulling Filter Using Effective Channel Information for Full Duplex Systems
Authors: Na Hyunjong , Lee Chungyong 
Published: September 2019

Abstract
We propose a spatial domain interference cancelation scheme for full duplex bi-directional communication systems. Although the conventional pre-processing filters, such as null space projection and minimum mean square error (MMSE), can eliminate self interference, they require the spatial dimensions more than the number of receive antennas. However, proposed scheme requires only one spatial dimension regardless of the number of receive antennas, which enables more efficient antenna allocation. Simulation results show that proposed scheme obtains higher achievable rate than the half duplex system and the MMSE filter.
Evaluation of effect factors on water quality of Karun River in downstream and lake of the Gotvand-e-Olya Dam (SW Iran)
Authors: Jahangiry Fard M. , Amanipoor H. , Battaleb-Looie S. , Ghanemi K. 
Published: September 2019

Abstract
Outcrop of Gachsaran evaporative formation in the lake of Gotvand-e-Olya Dam in SW IRAN has posed a major challenge in terms of water quality. In the present study, multivariate statistical analysis, ionic ratios, and Piper diagram were utilized to investigate the effect of formation dissolution on water quality. Sampling was performed two times with a time interval of 6 months. The result showed that the types of downstream samples are Cl–Na and Cl–Ca, which are affected by the dissolution of Gachsaran Formation and reverse ion exchange. Due to the transmission of the saline water to the depth and layering of reservoir, the water types in the upper levels of dam’s lake are (SO4–Ca and HCO3–Ca) and (Cl–Ca and SO4–Ca) upon the first and second sampling, respectively. In both times, the clustering of the EC, TDS, Na, and Cl parameters demonstrates the effect of halite dissolution on water quality in downstream and lake of the dam. At the first sampling, the SO4 and HCO3 parameters are in one cluster that shows increasing calcareous formation dissolution. At the second time, the grouping of the Ca and SO4 parameters shows the effect of gypsum and anhydrite dissolution on water quality. In both sampling times, the stations are grouped based on distance to the dam such that upstream stations are in one cluster. Results of principal component analysis show that data of the first-time sampling are summarized into two factors that show the effect of the formation dissolution and rainfall effect on water quality, respectively. At the second-time sampling, studied parameters are summarized in one factor. Local conditions of the studied area indicate the dominant effect of formation dissolution on water quality. The results of ionic ratios confirm the effect of geological formation on water quality in the lake and downstream of the dam. Due to the water layering, in terms of salinity in the dam’s lake, the rate and discharge of water outflow of the dam also affect the water quality in downstream.
Bulimic symptoms in a sample of college women: disentangling the roles of body size, body shame and negative urgency
Authors: Dalley Simon E. , Bron Glenda G. , Hagl Iona F. A. , Heseding Frederic , Hoppe Sabine , Wit Lotte 
Published: September 2019

AbstractPurpose This study set out to disentangle the roles of body size, body shame and negative urgency on bulimic symptomatology in a sample of college women. We predicted that body shame would mediate the relationship between body size and bulimic symptomatology: with increasing body size, the greater would be the experience of body shame and, in turn, the greater the bulimic symptomatology. We also predicted that negative urgency would exacerbate this mediation pathway, and that the moderated mediation model would occur over and above current levels of depression.MethodA convenience sample of 237 college women indicated their age, height and weight and then completed measures of body shame, negative urgency, depression and bulimic symptomatology. Bootstrap analysis was used to test the predicted moderation mediation model.ResultsThe bootstrap analysis supported all predictions. Thus, with greater the increase in body size, the greater was the body shame and the more frequent bulimic symptomatology. Furthermore, negative urgency moderated the relationship between body shame and bulimic symptomatology, such that those with both higher negative urgency and body shame had more frequent bulimic symptomatology.ConclusionsResults suggest that those college women higher in both BMI and negative urgency are likely to experience higher levels of bulimic symptoms. These women may benefit from emotion regulation interventions targeted at preventing, as well as coping effectively with, the experience of body shame.Level of evidenceV: cross-sectional descriptive study.
Zinc causes the death of hypoxic astrocytes by inducing ROS production through mitochondria dysfunction
Authors: Pan Rong , Liu Ke Jian , Qi Zhifeng 
Published: September 2019

Abstract
Cerebral ischemia triggers a cascade of events that contribute to ischemic brain damages. Zinc release and accumulation has been shown to lead to brain cell death following cerebral ischemia. However, the mechanism underlying remains to be elucidated. Our recently published work showed that suppression of mitochondrial-derived reactive oxygen species (ROS) production significantly reduced ischemic stroke related brain damage within 6 h. Herein, we investigated the relationship between zinc accumulation and mitochondrial-derived ROS production in astrocytes after 3-h hypoxia. We found that inhibition of mitochondrial-derived ROS significantly decreased total amount of ROS generation and cell death in primary astrocytes during hypoxia when zinc was overload. In contrast, the inhibition of NADPH oxidase-derived ROS had less of an effect. Our results also showed that zinc and mitochondria were colocalized in hypoxic astrocytes. Moreover, extracellular zinc addition caused zinc accumulation in the mitochondria and decreased mitochondrial membrane potential, leading to mitochondria dysfunction. These findings provide a novel mechanism that zinc accumulation contributes to hypoxia-induced astrocytes death by disrupting mitochondria function, following cerebral ischemia.
Differences in service utilization at an urban tribal health organization before and after Alzheimer's disease or related dementia diagnosis: A cohort study
Authors: Schaefer Krista R. , Noonan Carolyn , Mosley Michael , Smith Julia , Galbreath Donna , Fenn David , Robinson Renee F. , Manson Spero M. 
Published: September 2019

AbstractIntroductionThe prevalence, mortality, and healthcare impact of Alaska Native and American Indian (ANAI) people with Alzheimer's disease and related dementias (ADRD) are unknown.MethodsWe conducted a cohort study of electronic health record data that compared healthcare service utilization in patients with and without an ADRD diagnosis. Zero‐inflated negative binomial regression with robust standard errors was used to estimate utilization rates.ResultsCompared with patients without ADRD, utilization rates were similar before but higher after ADRD diagnosis. For those with diagnosed ADRD, utilization increased gradually over time with sharp upward change during the year of diagnosis.DiscussionThis is the only study quantifying changes in healthcare service utilization before and after ADRD diagnosis among ANAI people, which is crucial for tailoring geriatric care for ANAI populations.
Tertullian's Chameleon
Authors: Leyerle Blake 
Published: September 2019

AbstractTertullian's treatiseDe palliois the briefest and most difficult of the North African's works. Its purpose, ostensibly, is to advocate for a change in clothing from the toga to the pallium. This sartorial shift functions, in turn, as a metaphor for conversion to the philosophical life, which, at the end of the treatise, is revealed to be the Christian life. Towards the centre of the work, Tertullian turns to nature to support his argument, citing the example of five different animals. This essay analyses his description of the chameleon, arguing that it is a riddle: drawing on the natural historians, Tertullian paints a realistic picture of the small lizard, but at the same time, skews the description of these features to depict the philosopher. The purpose of this central sketch is to alert listeners to the nature of the speech as a guessing game, and to point to the complex identity of the speaker.
Correlates of infection withHelicobacter pyloripositive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem
Authors: Muhsen K. , Sinnereich R. , Beer-Davidson G. , Nassar H. , Abu Ahmed W. , Cohen D. , Kark J. D. 
Published: September 2019

AbstractWe examined the prevalence and correlates ofHelicobacter pylori(H. pylori) infection according to cytotoxin-associated gene A (CagA) phenotype, a main virulence antigen, among the ethnically diverse population groups of Jerusalem. A cross-sectional study was undertaken in Arab (N= 959) and Jewish (N= 692) adults, randomly selected from Israel's national population registry in age-sex and population strata. Sera were tested forH. pyloriimmunoglobulin G (IgG) antibodies. Positive samples were tested for virulence IgG antibodies to recombinant CagA protein, by enzyme-linked immunosorbent assay. Multinomial regression models were fitted to examine associations of sociodemographic factors withH. pyloriphenotypes.H. pyloriIgG antibody sero-prevalence was 83.3% (95% confidence interval (CI) 80.0%–85.5%) and 61.4% (95% CI 57.7%–65.0%) among Arabs and Jews, respectively. AmongH. pyloripositives, the respective CagA IgG antibody sero-positivity was 42.3% (95% CI 38.9%–45.8%) and 32.5% (95% CI 28.2%–37.1%). Among Jews, being born in the Former Soviet Union, the Middle East and North Africa,vs.Israel and the Americas, was positively associated with CagA sero-positivity. In both populations, sibship size was positively associated with both CagA positive and negative phenotypes; and education was inversely associated. In conclusion, CagA positive and negative infection had similar correlates, suggesting shared sources of these twoH. pyloriphenotypes.