bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examination of Health System Resources and Costs Associated With Transitioning Cancer Survivors to Primary Care: A Propensity-Score–Matched Cohort Study
Authors: Mittmann Nicole , Beglaryan Hasmik , Liu Ning , Seung Soo Jin , Rahman Farah , Gilbert Julie , De Rossi Stefanie , Earle Craig C. , Grunfeld Eva , Zwicker Victoria , LeBlanc Dominique , Sussman Jonathan 
Published: October 2018

Background: Transitioning low-risk cancer survivors back to their primary care provider (PCP) has been shown to be safe but the effect on health system resources and costs has not been examined. Methods: A Well Follow-Up Care Initiative (WFCI) was implemented in the publicly funded health system. Low-risk breast cancer (BC) survivors in the WFCI intervention group were transitioned from oncologist-led cancer clinics to PCPs. We compared health system costs ($2,014 in Canadian dollars) and resource utilization in this intervention group with that in propensity-score–matched nontransitioned BC survivors (ie, controls) diagnosed in the same year, with similar disease profile and patient characteristics using publicly funded administrative databases. Results: A total of 2,324 BC survivors from the WFCI intervention group were 1:1 matched to controls and observed for 25 months. Compared with controls, survivors in the intervention group incurred a similar number of PCP visits (6.9 v 7.5) and fewer oncologist visits (0.3 v 1.2) per person-year. Fewer survivors in the intervention group (20.1%) were hospitalized than in the control group (24.4%). There were no differences in emergency visits. More survivors in the intervention group had mammograms (82.6% v 73.1%), but other diagnostic tests were less frequent. There was a 39.3% reduction in overall mean annual costs ($6,575 v $10,832) and a 22.1% reduction in overall median annual costs ($2,261 v $2,903). Overall survival in the intervention group was not worse than controls. Conclusion: Transitioning low-risk BC survivors to PCPs was associated with lower health system resource use and a lower annual cost per patient than matched controls. The WFCI model represents a reasonable approach at the population level to delivering quality care for low-risk BC survivors that seems to be cost effective.
Adult-Onset Hepatocyte GH Resistance Promotes NASH in Male Mice, Without Severe Systemic Metabolic Dysfunction
Authors: Cordoba-Chacon Jose , Sarmento-Cabral Andre , del Rio-Moreno Mercedes , Diaz-Ruiz Alberto , Subbaiah Papasani V , Kineman Rhonda D 
Published: October 2018

AbstractNonalcoholic fatty liver disease (NAFLD), which includes nonalcoholic steatohepatitis (NASH), is associated with reduced GH input/signaling, and GH therapy is effective in the reduction/resolution of NAFLD/NASH in selected patient populations. Our laboratory has focused on isolating the direct vs indirect effects of GH in preventing NAFLD/NASH. We reported that chow-fed, adult-onset, hepatocyte-specific, GH receptor knockdown (aHepGHRkd) mice rapidly (within 7 days) develop steatosis associated with increased hepatic de novo lipogenesis (DNL), independent of changes in systemic metabolic function. In this study, we report that 6 months after induction of aHepGHRkd early signs of NASH develop, which include hepatocyte ballooning, inflammation, signs of mild fibrosis, and elevated plasma alanine aminotransferase. These changes occur in the presence of enhanced systemic lipid utilization, without evidence of white adipose tissue lipolysis, indicating that the liver injury that develops after aHepGHRkd is due to hepatocyte-specific loss of GH signaling and not due to secondary defects in systemic metabolic function. Specifically, enhanced hepatic DNL is sustained with age in aHepGHRkd mice, associated with increased hepatic markers of lipid uptake/re-esterification. Because hepatic DNL is a hallmark of NAFLD/NASH, these studies suggest that enhancing hepatocyte GH signaling could represent an effective therapeutic target to reduce DNL and treat NASH.
Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males
Authors: Miller Geoffrey D , Moore Chad , Nair Vinod , Hill Brian , Willick Stuart E , Rogol Alan D , Eichner Daniel 
Published: October 2018

Abstract

Context
Clomiphene is a performance-enhancing drug commonly abused by males in sport, but the extent to which testosterone increases in healthy males following its use is unknown. In addition, evidence suggests that clomiphene, a mixture of cis- and trans-isomers zuclomiphene and enclomiphene, is detectable in urine for months following use; the isomer-specific urinary detection window has yet to be characterized in a controlled study.

Objective
To determine the effect of once-daily, 30-day clomiphene treatment on serum testosterone and gonadotropin levels in the subject population studied and the urinary clearance and detection window of clomiphene isomers following administration for antidoping purposes.

Participants and Design
Twelve healthy males aged 25 to 38 years, representing a recreational athlete population, participated in this open-label, single-arm study.

Intervention
Oral clomiphene citrate (50 mg) was self-administered once daily for 30 days. Serum and urine samples were collected at baseline and at days 7, 14, 21, 28, 30, 32, 35, 37, 44, 51, and 58; urine collections continued periodically up to day 261.

Results
Mean testosterone, LH, and FSH levels increased 146% (SEM, ±23%), 177% (±34%), and 170% (±33%), respectively, during treatment compared with baseline. Serum drug concentrations and urinary excretion were nonuniform among individuals as isomeric concentrations varied. The zuclomiphene urinary detection window ranged from 121 to &gt;261 days.

Conclusions
Clomiphene significantly raised serum testosterone and gonadotropin levels in healthy men and thus can be abused as a performance-enhancing drug. Such abuse is detectable in urine for ≥4 months following short-term use.
A review of endovascular treatment of thoracic aorta disease
Authors: Tan GJS , Khoo PLZ , Chan KMJ 
Published: October 2018

Introduction The development of thoracic endovascular aortic repair has altered the approach and reduced the risk of treating the majority of descending thoracic aortic conditions. Primarily developed for the exclusion of thoracic aortic aneurysms, it is now used in place of open repair surgery for most descending thoracic aortic diseases, and has also been used to treat aortic arch diseases in selected cases. Methods A literature search was conducted of Medline and Embase databases from January 2007 to February 2017, using the key words ‘aortic disease’, ‘thoracic aorta’ and ‘endovascular repair’; 205 articles were identified, of which 25 studies were selected for review based on their relevance. Findings The key findings of the indications, techniques, outcomes, complications and comparisons with open surgical repair were extracted from the published studies and are summarised in this review. Thoracic endovascular aortic repair is the preferred choice of intervention for patients with descending thoracic aortic disease. With time, it has improved to be safer and has the potential to expand aortic treatment choices in future.
Surgery for Cushing’s disease in pregnancy: our experience and a literature review
Authors: Jolly K , Darr A , Arlt W , Ahmed S , Karavitaki N 
Published: October 2018

Cushing’s syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing’s disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing’s syndrome in pregnancy is often delayed due to overlap of symptoms. In addition, there are no validated diagnostic tests or parameters documented. We present a case of a 30-year-old woman presenting to the antenatal clinic at 13 weeks of pregnancy with high suspicion of Cushing’s disease. Her 21-week fetal scan showed a congenital diaphragmatic hernia and she underwent pituitary magnetic resonance imaging, which confirm Cushing’s disease. She successfully underwent transsphenoidal adenomectomy with histology confirming a corticotroph adenoma. Tests following transsphenoidal surgery confirmed remission of Cushing’s disease and she underwent an emergency caesarean section at 38 weeks. Unfortunately, her baby died from complications associated with the congenital abnormality 36 hours after birth. The patient remains in remission following delivery. To date, there have been no reported cases of congenital diaphragmatic hernia associated with Cushing’s disease in pregnancy. In addition, we believe that this is only the eighth reported patient to have undergone successful transsphenoidal surgery for Cushing’s disease in pregnancy.
Gaussian heat kernel estimates: From functions to forms
Authors: Coulhon Thierry , Devyver Baptiste , Sikora Adam 
Published: October 2018

Abstract
On a complete non-compact Riemannian manifold satisfying the volume doubling property, we give conditions on the negative part of the Ricci curvature that
ensure that, unless there are harmonic 1-forms, the Gaussian heat kernel upper estimate on functions transfers to one-forms. These conditions do no entail any constraint on the size of the Ricci curvature, only on its decay at infinity.
Left semi-braces and solutions of the Yang–Baxter equation
Authors: Jespers Eric , Van Antwerpen Arne 
Published: October 2018

AbstractLetr:X2→X2{r\colon X^{2}\rightarrow X^{2}}be a set-theoretic solution of the Yang–Baxter equation on a finite setX. It was proven by Gateva-Ivanova and Van den Bergh that ifris non-degenerate and involutive, then the algebraK⁢〈x∈X∣x⁢y=u⁢v⁢ if ⁢r⁢(x,y)=(u,v)〉{K\langle x\in X\mid xy=uv\text{ if }r(x,y)=(u,v)\rangle}shares many properties with commutative polynomial algebras in finitely many variables; in particular, this algebra is Noetherian, satisfies a polynomial identity and has Gelfand–Kirillov dimension a positive integer. Lebed and Vendramin recently extended this result to arbitrary non-degenerate bijective solutions. Such solutions are naturally associated to finite skew left braces. In this paper we will prove an analogue result for arbitrary solutionsrB{r_{B}}that are associated to a left semi-braceB; such solutions can be degenerate or can even be idempotent. In order to do so, we first describe such semi-braces and then prove some decompositions results extending those of Catino, Colazzo and Stefanelli.
On the spectralization of affine and perfectly normal spaces
Authors: Golasiński Marek , Bilski Paweł 
Published: October 2018

Abstract
We show that for a field K and

n
≥
1

{n\geq 1}

, the soberification

𝒮
⁢

(

𝔸
n

⁢

(
K
)

)

{\mathcal{S}(\mathbb{A}^{n}(K))}

of the affine n-space

𝔸
n

⁢

(
K
)

{\mathbb{A}^{n}(K)}

over K is homeomorphic to its spectralization

ℬ
⁢
𝒮
⁢

(

𝔸
n

⁢

(
K
)

)

{\mathcal{BS}(\mathbb{A}^{n}(K))}

, and it can be embedded into the spectrum

Spec
⁢

(

K
⁢

[

X
1

,
…
,

X
n

]

)

{\mathrm{Spec}(K[X_{1},\dots,X_{n}])}

. Moreover, if the field K is algebraically closed, then there are homeomorphisms

𝒮
⁢

(

𝔸
n

⁢

(
K
)

)

≈

ℬ
⁢
𝒮
⁢

(

𝔸
n

⁢

(
K
)

)

≈

Spec
⁢

(

K
⁢

[

X
1

,
…
,

X
n

]

)

\mathcal{S}(\mathbb{A}^{n}(K))\approx\mathcal{BS}(\mathbb{A}^{n}(K))\approx%
\mathrm{Spec}(K[X_{1},\dots,X_{n}])

.
We also show that for a space X, the subspace

z
⁢
Spec
⁢

(

C
⁢

(
X
)

)

⊆

Spec
⁢

(

C
⁢

(
X
)

)

z\mathrm{Spec}(C(X))\subseteq\mathrm{Spec}(C(X))

of prime z-ideals of the ring

C
⁢

(
X
)

{C(X)}

of real-valued continuous functions on X is homeomorphic to the space

z
⁢
𝒮
⁢
ℛ
⁢

(
X
)

{z\mathcal{SR}(X)}

of prime z-filters with an appropriate topology and there is a homeomorphism

ℬ
⁢
𝒮
⁢

(
X
)

≈

z
⁢
Spec
⁢

(

C
⁢

(
X
)

)

{\mathcal{BS}(X)\approx z\mathrm{Spec}(C(X))}

provided X is perfectly normal.
Generalized Jiang and Gottlieb groups
Authors: Golasiński Marek , de Melo Thiago 
Published: October 2018

Abstract
Given a map

f
:

X
→
Y

{f\colon X\to Y}

, we extend Gottlieb’s result to the generalized Gottlieb group

G
f

⁢

(
Y
,

f
⁢

(

x
0

)

)

{G^{f}(Y,f(x_{0}))}

and show that the canonical isomorphism

π
1

⁢

(
Y
,

f
⁢

(

x
0

)

)

⁢

→
≈

⁢
𝒟
⁢

(
Y
)

{\pi_{1}(Y,f(x_{0}))\overset{\approx}{\to}\mathcal{D}(Y)}

restricts to an isomorphism

G
f

⁢

(
Y
,

f
⁢

(

x
0

)

)

⁢

→
≈

⁢

𝒟

f
~

0

⁢

(
Y
)

{G^{f}(Y,f(x_{0}))\overset{\approx}{\to}\mathcal{D}^{\tilde{f}_{0}}(Y)}

, where

𝒟

f
~

0

⁢

(
Y
)

{\mathcal{D}^{\tilde{f}_{0}}(Y)}

is some subset of the group

𝒟
⁢

(
Y
)

{\mathcal{D}(Y)}

of deck transformations of Y for a fixed lifting

f
~

0

{\tilde{f}_{0}}

of f with respect to universal coverings of X and Y, respectively.
Hydrodynamics and Reaction Performances of Multiphase Reactors for Marine Applications – A Review
Authors: Iliuta Ion , Larachi Faïçal 
Published: October 2018

AbstractHydrodynamics and (catalytic & non-catalytic) reaction [high-pressure hydrodesulfurization; Fischer-Tropsch synthesis; CO2-monoethanolamine (MEA) absorption; simultaneous CO2and H2S absorption in MEA; CO2thermal desorption, enzymatic CO2hydration] performances of trickle-bed and packed-bed column reactors subjected to static inclination, rolling (symmetrical/asymmetrical externally-generated reactor oscillations) and heaving motions were analyzed via detailed dynamic 3-D models which couple the macroscopic volume-averaged momentum, mass, energy and species balance equations in the liquid/gas phases with diffusion/chemical reaction inside the catalyst particles, enzyme washcoat or liquid film near the gas-liquid interface. Axial symmetry breakdown once the packed bed systems become inclined inflicts noticeable reductions of the reactor (or scrubber) performances. Only the performance of Fischer-Tropsch synthesis in the presence of water-gas shift reaction increases slightly with the increase of trickle-bed reactor inclination because of facile uptake of reactants in the key reactions from the gas phase while a fraction of valuable CO can be forwarded in water gas-shift reaction. For most of the reactions examined, the reactor performance is negatively impacted in asymmetric oscillating multiphase reactors with Fischer-Tropsch synthesis as an exception owing to the presence of water-gas shift reaction the performance of which is slightly improved. This performance deterioration/enhancement is maximal for the reactor moving between vertical and an inclined position when the time-dependent performance waves develop around the steady-state solution of the mid-inclination angle. The oscillatory reactor performance moves towards the steady-state solution of the vertical state when the asymmetry between the two inclined positions dwindles. Symmetric oscillating and heaving trickle-bed and packed-bed column reactors generate an oscillatory performance around the steady-state solution of vertical state which is affected by the amplitude and period of the angular and heaving motions of the vessel.
Fusions and Clifford extensions
Authors: Coconeţ Tiberiu , Marcus Andrei , Todea Constantin-Cosmin 
Published: October 2018

Abstract
We introduce

G
¯

{\overline{G}}

-fusions of local pointed groups on a block extension

A
=

b
⁢
𝒪
⁢
G

{A\kern-1.0pt=\kern-1.0ptb\mathcal{O}G}

, where H is a normal subgroup of the finite group G,

G
¯

=

G
/
H

{\overline{G}=G/H}

, and b is a G-invariant block of

𝒪
⁢
H

{\mathcal{O}H}

. We show that certain Clifford extensions associated to these pointed groups are invariant under group graded basic Morita equivalences.
A detailed analysis of the hybrid lattice-reduction and meet-in-the-middle attack
Authors: Wunderer Thomas 
Published: October 2018

Abstract
Over the past decade, the hybrid lattice-reduction and meet-in-the middle attack (called hybrid attack) has been used to evaluate the security of many lattice-based cryptographic schemes such as NTRU, NTRU Prime, BLISS and more.
However, unfortunately, none of the previous analyses of the hybrid attack is entirely satisfactory: They are based on simplifying assumptions that may distort the security estimates.
Such simplifying assumptions include setting probabilities equal to 1, which, for the parameter sets we analyze in this work, are in fact as small as

2

-
80

2^{-80}

.
Many of these assumptions lead to underestimating the scheme’s security.
However, some lead to security overestimates, and without further analysis, it is not clear which is the case.
Therefore, the current security estimates against the hybrid attack are not reliable, and the actual security levels of many lattice-based schemes are unclear.
In this work, we present an improved runtime analysis of the hybrid attack that is based on more reasonable assumptions.
In addition, we reevaluate the security against the hybrid attack for the NTRU, NTRU Prime and R-BinLWEEnc encryption schemes as well as for the BLISS and GLP signature schemes.
Our results show that there exist both security over- and underestimates in the literature.
Optimizing Between-Session Reliability for Quadriceps Peak Torque and Rate of Torque Development Measures
Authors: Grindstaff Terry L. , Palimenio Marcus R. , Franco Matthew , Anderson Dillon , Bagwell Jennifer J. , Katsavelis Dimitrios 
Published: October 2018

Abstract
Grindstaff, TL, Palimenio, MR, Franco, M, Anderson, D, Bagwell, JJ, and Katsavelis, D. Optimizing between-session reliability for quadriceps peak torque and rate of torque development measures. J Strength Cond Res 33(7): 1840–1847, 2019—Quadriceps peak torque and rate of torque development (RTD) have relevance for athletic performance and recovery after knee injury. The number of repetitions performed to determine RTD varies between studies, and the associated measurement error has not been established. The purpose of this study was to determine the number of repetitions necessary to optimize the between-session reliability for isometric quadriceps peak torque and RTD measures and to quantify estimates of measurement error. Twenty participants (age = 21.7 ± 1.7 years, height = 172.5 ± 16.0 cm, body mass = 76.0 ± 15.5 kg, and Tegner = 7.1 ± 1.2) volunteered for this study. Quadriceps isometric peak torque and RTD (50, 100, 150, 200, and 250 ms, and maximum torque) were obtained during 2 testing sessions. Between-session reliability was determined using intraclass correlation coefficients (ICC2,k), using the minimal detectable change (MDC) and coefficient of variation (CoV) to quantify measurement error. Between-session reliability was best maximized by using the average of the 3 repetitions with the highest peak torque. Reliability was good for quadriceps peak torque (ICC2,3 = 0.98; MDC = 51.1 N·m; CoV = 38.0%) and ranged from moderate to good for quadriceps RTD measures (ICC2,3 = 0.61 to 0.91; MDC = 264.8 to 738.3 N·m·s−1; CoV = 38.1–57.9%). Measures of late RTD were less variable and more reliable than early RTD and average RTD measures. These results provide confidence when measuring between-session changes for late RTD measures, but changes in early RTD may be more difficult to distinguish from measurement error. Methods should be used to minimize variability between repetitions and sessions.
Pacing Profiles of Olympic and IAAF World Championship Long-Distance Runners
Authors: Filipas Luca , La Torre Antonio , Hanley Brian 
Published: October 2018

Abstract
Filipas, L, La Torre, A, and Hanley, B. Pacing profiles of Olympic and International Association of Athletics Federations World Championship long-distance runners. J Strength Cond Res 35(4): 1134–1140, 2021—The aim of this study was to analyze the pacing profiles of Olympic and International Association of Athletics Federations (IAAF) World Championship long-distance finalists, including the relationship with their recent best times. The times for each 1,000-m split were obtained for 394 men and women in 5,000- and 10,000-m finals at 5 championships. Athletes' best times from the previous 32 months were also obtained. Similar pacing profiles were used by athletes grouped by finishing position in 5,000-m races. Women adopted a more even pacing behavior, highlighting a possible sex-based difference over this distance. Pacing behavior over 10,000 m was more similar between men and women compared with over 5,000 m. The main difference between men and women was that in the men's 10,000 m, as in the men's 5,000 m, more athletes were able to follow the leading group until the final stages. There were large or very large correlations between athletes' best times from the previous 32 months and their result; the fastest finishers also ran closer to their previous 32 months' best times. Despite differences in pacing behavior between events, long-distance runners should nonetheless stay close to the front from the beginning to win a medal.
Theory and Application of the Internal Leakage Detection of Open-Circuit Hydraulic Systems Based on Active Hydraulic Test Technology
Authors: Chenggang Yang , Jingyi Zhao , Hao Sun , Lixuan Yang , Ruixin Zhang 
Published: October 2018

Abstract
With the rapid development of hydraulic technology, hydraulic systems have become more complex, and the detection of internal leakage is becoming more and more difficult. A fast and accurate approach is required to detect the internal leakage of a hydraulic system. This article describes the theory and application of the internal leakage detection of open-circuit hydraulic systems based on Active Hydraulic Test Technology. The theory of Active Hydraulic Test Technology is introduced, a leakage model and an online detection model of an open-circuit hydraulic system are established, and the total leakage of the hydraulic system is theoretically analyzed. A theoretical analysis of the leakage test method for the main control oil circuit and branch components is also conducted. Through applied research on a hydraulic system of a 1,250-ton forging machine, the effectiveness of the method for detecting the internal leakage fault of a complex hydraulic system is verified.
Investigation on Microwave Heating Technology for Rutting Maintenance in Asphalt Pavement
Authors: Wu Shuyin , Yang Jun , Yang Ruochong , Zhu Jipeng , Liu Song 
Published: October 2018

Abstract
As one of the major diseases of asphalt pavement, rutting has become an important research topic. The current treatment method of rutting generally requires the milling of asphalt layers and construction of a new overlay, which is time-consuming and costly. Microwave heating is a promising technology for asphalt pavement maintenance. This research aimed to introduce microwave heating into the in situ rutting rehabilitation. The effects of microwaves on the aging of asphalt and mechanical properties of asphalt mixtures were discussed. The mechanism and effects of microwave maintenance were explored at the macroscopic and microscopic scale with the British Pendulum Test, X-ray Computed Tomography, Asphalt Extraction Test, and Discrete Element Method. The experiments showed that the microwaves have little negative effect on the performance of asphalt and asphalt mixtures. The analysis of the formation process of rutting showed that asphalt or asphalt cement shows bottom-up migration while the coarse aggregates move down. Overall, the research indicates that the general effect of microwave maintenance is an improvement in the rutting resistance of asphalt pavement, suggesting that rutting maintenance using microwave heating is feasible in practice.