bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anchorene is an endogenous diapocarotenoid required for anchor root formation in Arabidopsis
Authors: Jia Kun-Peng , Dickinson Alexandra J. , Mi Jianing , Cui Guoxin , Kharbatia Najeh M. , Guo Xiujie , Sugiono Erli , Aranda Manuel , Rueping Magnus , Benfey Philip N. , Al-Babili Salim 
Published: December 2018

AbstractArabidopsis root development is predicted to be regulated by yet unidentified carotenoid-derived metabolite(s). In this work, we screened known and putative carotenoid cleavage products and identified anchorene, a predicted carotenoid-derived dialdehyde (diapocarotenoid) that triggers anchor root development. Anchor roots are the least characterized type of root in Arabidopsis. They form at the root-shoot junction, particularly upon damage to the root apical meristem. Using Arabidopsis reporter lines, mutants and chemical inhibitors, we show that anchor roots originate from pericycle cells and that the development of this root type is auxin-dependent and requires carotenoid biosynthesis. Transcriptome analysis and treatment of auxin-reporter lines indicate that anchorene triggers anchor root development by modulating auxin homeostasis. Exogenous application of anchorene restored anchor root development in carotenoid-deficient plants, indicating that this compound is the carotenoid-derived signal required for anchor root development. Chemical modifications of anchorene led to a loss of anchor root promoting activity, suggesting that this compound is highly specific. Furthermore, we demonstrate by LC-MS analysis that anchorene is a natural, endogenous Arabidopsis metabolite. Taken together, our work reveals a new member of the family of carotenoid-derived regulatory metabolites and hormones.SignificanceUnknown carotenoid-derived compounds are predicted to regulate different aspects of plant development. Here, we characterize the development of anchor roots, the least characterized root type in Arabidopsis, and show that this process depends on auxin and requires a carotenoid-derived metabolite. We identified a presumed carotenoid-derivative, anchorene, as the likely, specific signal involved in anchor root formation. We further show that anchorene is a natural metabolite that occurs in Arabidopsis. Based on the analysis of auxin reporter lines and transcriptome data, we provide evidence that anchorene triggers the growth of anchor roots by modulating auxin homeostasis. Taken together, our work identifies a novel carotenoid-derived growth regulator with a specific developmental function.
Do no harm and do more good too: connecting the SDGs with business and human rights and political CSR theory
Authors: Buhmann Karin , Jonsson Jonas , Fisker Mette 
Published: December 2018

Purpose
This paper aims to explain how companies can benefit from their human rights due diligence process to identify opportunities for sustainable development goals (SDGs) activities in an operationalisation of political corporate social responsibility (PCSR).

Design/methodology/approach
Combining PCSR, SDGs and business and human rights (BHR) literature, the paper develops an extension of the risk-based due diligence process described by the BHR literature, helping companies identify societal needs to which they may contribute in accordance with PCSR through engaging in the SDGs.

Findings
Companies can benefit from resources they already invest in due diligence to identify their adverse human rights impacts, by drawing on the insights gained on broader needs, including human rights, to which they may contribute. This can help them develop appropriate interventions to address local needs and advance their moral legitimacy through assisting in SDG-relevant fulfilment of human rights.

Research limitations/implications
The paper provides theory-based guidance on how companies can assess their capacity for contributing societal value through human rights-oriented SDG interventions. Future empirical research may explore how companies apply the extended due diligence process to assess needs and determine relevant actions.

Practical implications
The paper offers a principle-based analytical approach for integrating the “do no harm” imperative of BHR theory with PCSR’s call for business assistance in the delivery of public goods and the SDGs’ call for business action to “do good’.

Social implications
This paper enables enhanced business implementation of the SDGs in line with PCSR and human rights theory, especially the emergent field of business and human rights.

Originality/value
This study gives theory-based guidance for companies for SDG contributions based on innovative combination of literatures.
A data-driven neural network architecture for sentiment analysis
Authors: Çano Erion , Morisio Maurizio 
Published: December 2018

Purpose
The fabulous results of convolution neural networks in image-related tasks attracted attention of text mining, sentiment analysis and other text analysis researchers. It is, however, difficult to find enough data for feeding such networks, optimize their parameters, and make the right design choices when constructing network architectures. The purpose of this paper is to present the creation steps of two big data sets of song emotions. The authors also explore usage of convolution and max-pooling neural layers on song lyrics, product and movie review text data sets. Three variants of a simple and flexible neural network architecture are also compared.

Design/methodology/approach
The intention was to spot any important patterns that can serve as guidelines for parameter optimization of similar models. The authors also wanted to identify architecture design choices which lead to high performing sentiment analysis models. To this end, the authors conducted a series of experiments with neural architectures of various configurations.

Findings
The results indicate that parallel convolutions of filter lengths up to 3 are usually enough for capturing relevant text features. Also, max-pooling region size should be adapted to the length of text documents for producing the best feature maps.

Originality/value
Top results the authors got are obtained with feature maps of lengths 6–18. An improvement on future neural network models for sentiment analysis could be generating sentiment polarity prediction of documents using aggregation of predictions on smaller excerpt of the entire text.
Novel reliable routing method for engineering of internet of vehicles based on graph theory
Authors: Zhang De-gan , Tang Ya-meng , Cui Yu-ya , Gao Jing-xin , Liu Xiao-huan , Zhang Ting 
Published: December 2018

Purpose
The communication link in the engineering of Internet of Vehicle (IOV) is more frequent than the communication link in the Mobile ad hoc Network (MANET). Therefore, the highly dynamic network routing reliability problem is a research hotspot to be solved.

Design/methodology/approach
The graph theory is used to model the MANET communication diagram on the highway and propose a new reliable routing method for internet of vehicles based on graph theory.

Findings
The expanded graph theory can help capture the evolution characteristics of the network topology and predetermine the reliable route to promote quality of service (QoS) in the routing process. The program can find the most reliable route from source to the destination from the MANET graph theory.

Originality/value
The good performance of the proposed method is verified and compared with the related algorithms of the literature.
A bibliometric analysis of inventory management research based on knowledge mapping
Authors: Ye Yong , Ge Yuanqin 
Published: December 2018

Purpose
The research mainly aims at the hotspot of inventory management by knowledge mapping and provides a visualization reference in this research field.

Design/methodology/approach
First, inventory management journals during 1986 to 2017 were selected as the research object and text formatting in the Web of Science (WOS) database is exported. Then inventory management knowledge mapping is done and clustering keywords are extracted by using CiteSpace and VOSviewer software. Based on co-word analysis, the three special clusters are exported: inventory optimization strategy, inventory pricing and inventory technology. Besides, the clustering structure and time evolution are analysed. Finally, bibliographic item co-occurrence matrix builder (BICOMB) was used to extract the “journal” and “researchers” keywords in the inventory management research fields. Setting three parameters such as the cited half-life, centrality, frequency and keywords for data mining, it can infer the trend keywords of future research.

Findings
Results showed that inventory management research has been abundant in literature over the past 30 years and has experienced a change from focusing on inventory optimization strategy to inventory pricing and inventory technology in process. It shows that inventory management research focused on the classic topics and includes economic order quantity, dynamic pricing, design and technology, and the new topics include channel coordination, hierarchical price and simulation.

Research limitations/implications
Based on knowledge mapping, this study is still relatively macro and cannot cover all areas of inventory management. This study only investigated the state of correlational research in WOS and Google Trends and not additional databases.

Originality/value
The current research mainly builds on knowledge mapping for the research hotspot of inventory management and provides visual references for future research in this field.
Performance-based contracting in military supply chains and the willingness to bear risks
Authors: van Strien Jeroen , Gelderman Cees Johannes , Semeijn Janjaap 
Published: December 2018

Purpose
Performance-based contracting (PBC) plays an increasingly important role in the defense industry. This paper aims to investigate factors that influence service provider’s willingness to accept PBC-induced risks. It also shows how these risks could be managed in a military service supply chain.

Design/methodology/approach
The case study focused on the relationship between a service provider and a customer that acted on behalf of other users in the defense sector. The contract involved the sustainment of a military engine in a complex supply chain.

Findings
The service provider’s performance attributability appeared to have a strong impact on its willingness to take PBC-induced risks. For the parts where the service provider did not have full control over the service performance, exclusions and Service Level Agreements (SLAs) were used to manage and mitigate the risks associated with uncontrolled performance. The service provider’s willingness to accept PBC-induced risks was also affected by its ability to make accurate forecasts, the applied growth path and the length of the contract.

Research limitations/implications
This case has specific characteristics, unique by time (maturity of the technical system and supply chain) and place (market). It is recommended that results are tested in other research settings.

Practical implications
Organizations should be aware of the factors that influence a service provider’s willingness to bear PBC-induced risks. Customers should limit PBC to those parts of a contract where risks are of an acceptable level. Also, it is recommended to follow a phased growth path when it is not possible to make accurate forecasts in a PBC context.

Originality/value
This study is the first to address critical issues concerning the identification and management of risks under PBC in the defense industry.
Disability and support relationships: What role does policy play?
Authors: Fisher Karen R. , Gendera Sandra , Graham Anne , Robinson Sally , Johnson Kelley , Neale Kate 
Published: December 2018

AbstractVery little is known about how relationships between people with disabilities and their paid support workers are positioned in policy. With the policy shift toward choice of provider, individualised approaches, person centredness and self‐directed funding, the nature of their relationship assumes a more prominent role in the quality of support practice. The policy analysis in this article explores the extent to which current disability policy acknowledges, promotes, or diminishes the relationships between people with disabilities and workers, in their organisational context. It uses Honneth's conditions for recognition—love (cared for), rights (respected) and solidarity or social esteem (valued)—to understand how policy positions mutuality in the relationship. The policy review applied a three‐stage process: categorisation of policies, textual analysis and content analysis to policy documents at four levels—international, Australian federal, state and organisational in two case studies. The analysis revealed that while a rights framework is explicit in most policies, the emphases on the conditions for recognition within a relationship between people with disabilities and workers are compromised in instructional policies that attempt to manage the tension between choice and risk, particularly at the organisational level.
Auditor Reporting and Regulatory Sanctions in the Broker‐Dealer Industry: From Self‐Regulation to PCAOB Oversight
Authors: Schnader Anne Leah , Bedard Jean C. , Cannon Nathan H. 
Published: December 2018

ABSTRACTThe financial security of the investing public relies on high‐quality service by broker‐dealers (BDs), investors' gateway to the financial markets. The SEC has long required auditors to attest to BDs' internal controls and compliance with regulations (including those privately owned). Following the unraveling of the Madoff Ponzi scheme in 2008, the SEC required auditors of all BDs to register with the PCAOB, and Congressional initiatives signaled imminent transition from private (AICPA) to public (PCAOB) oversight. We investigate whether audit quality increased following this transition by measuring whether auditors report material internal control and compliance problems for BD clients where a deficiency presumably existed (i.e., BDs sanctioned by the Financial Industry Regulatory Authority for transgressions against stakeholders). Overall, we do not find increased reporting quality following the regulatory shift but do observe variation by auditor group and BD ownership. While reporting quality for global network firms (GNFs) increases slightly, lower reporting quality observed prior to the regulatory shift for specialist audit firms (having large BD portfolios but small overall size) is exacerbated afterward. This finding complements results of PCAOB inspections and other research identifying audit quality problems among small, industry‐specialized firms in non‐public client settings. Focusing on deficiencies likely more difficult to detect, we find lower reporting quality for private relative to publicly affiliated BDs prior to PCAOB oversight, and lower reporting quality for very small audit firms relative to GNFs following the regulatory shift.
The disclosure of corporate social responsibility reports and sales performance in China
Authors: Yu Wei , Zheng Ying 
Published: December 2018

AbstractBased on legitimacy and stakeholder theory, we investigate whether there is an association between the disclosure of corporate social responsibility reports and a firm's sales performance in China. The empirical results reveal that the return on sales and sales growth are positively associated with the level of corporate social responsibility reporting in China. This positive association is strengthened when firms have concentrated customers. Firms use corporate social responsibility reports to improve sales performance and attract customers, who are one of their major stakeholders, and retain their legitimacy.
Impact of modified FOLFOX‐6 for patients with gastric cancer and a gastrointestinal obstruction
Authors: Yukami Hiroki , Terazawa Tetsuji , Goto Masahiro , Aoki Masahiko , Asaishi Ken , Yamaguchi Toshifumi , Kuwakado Shin , Kii Takayuki , Higuchi Kazuhide 
Published: December 2018

AbstractAimGastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX‐6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX‐6 for gastric cancer patients with a gastrointestinal obstruction.MethodsPatients with a poor oral intake because of a gastrointestinal obstruction who received mFOLFOX‐6 as systemic chemotherapy were retrospectively analyzed. Poor oral intake was defined as receiving a daily intravenous drip infusion due to a gastrointestinal obstruction.ResultsEighteen patients received mFOLFOX‐6; the median progression‐free survival was 6.8 months (95% confidence interval [CI], 1.9–9.7), the median overall survival was 8.0 months (95% CI, 2.8–20.8) and the median time to treatment failure was 2.2 months (95% CI, 1.2–5.7). An improved oral intake was observed in 13 of the 18 treated patients, with 12 of these continuing treatment as outpatients.ConclusionsA mFOLFOX‐6 treatment regimen seems promising for gastric cancer patients who have a gastrointestinal obstruction.
The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins
Authors: Swegen A. , Smith N. D. , Gibb Z. , Curry B. J. , Aitken R. J. 
Published: December 2018

AbstractBackground and ObjectivesSerine proteases are emerging as important players in the spermatozoon's acquisition of functional competence. This study aimed to characterize the serine protease testisin (PRSS21) in stallion spermatozoa, examining its surface expression, possible origins in the testis and epididymis, and changes in response to capacitation and acrosome reaction, as well as its capacity to form high molecular weight complexes and interact with other proteins.Materials and MethodsThe role of serine proteases in spontaneous capacitation and acrosome reaction of stallion spermatozoa was established using the serine protease inhibitor, AEBSF. Testisin localization, before and after exposure of stallion spermatozoa to capacitating conditions and calcium ionophore, was examined using live cell immunofluorescence and flow cytometry. Immunohistochemistry of testicular and epididymal tissues was used to further dissect the origins of sperm testisin. Testisin's participation in high molecular weight protein complexes and identification of its interacting partner proteins were investigated using Blue Native PAGE, co‐immunoprecipitation, and mass spectrometry, with interrogation of protein–protein interaction databases and gene ontology analysis of partner proteins used to further explore the potential roles of the testisin‐containing complex in sperm function.ResultsTestisin surface expression increased significantly in capacitated spermatozoa (p < 0.001), increased further following acrosome reaction (p < 0.01), and was localized to the equatorial region of the sperm head. Testisin was also detected in luminal fluid within the caput and corpus regions of the epididymis, epididymal spermatozoa, and epididymal epithelial cells. Testisin formed several multiprotein complexes; co‐immunoprecipitation revealed interactions of testisin with a multitude of zona pellucida‐binding proteins, including ZPBP, ZAN, acrosin, several heat‐shock proteins, and components of the TCP1 complex.ConclusionTestisin appears to form part of the zona pellucida‐binding complex in stallion spermatozoa and may be involved in the proteolytic cascade that prepares the sperm surface for interaction with the oocyte.
Circadian disruption and human health: A bidirectional relationship
Authors: Abbott Sabra M. , Malkani Roneil G. , Zee Phyllis C. 
Published: December 2018

AbstractCircadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.
Repetition priming effects for famous faces through dynamic causal modelling of latency‐corrected event‐related brain potentials
Authors: Kashyap Rajan , Bhattacharjee Sagarika , Sommer Werner , Zhou Changsong 
Published: December 2018

AbstractRepetition priming, that is, the repeated processing of a stimulus, facilitates performance. However, the neural underpinnings of repetition priming for famous faces in terms of effective connectivity are not known. Here we investigated this problem using dynamic causal modelling of latency‐corrected event‐related brain potentials (RERPs). Source waveforms of RERP‐derived sources in the Occipital Lobe, Fusiform Gyrus, Mediotemporal Lobe, Prefrontal Cortex and Anterotemporal Lobe of each hemisphere entered into models with only forward (F) or also with backward (FB) connections. Based on the framework of predictive coding formulated for repetition suppression, modulations of F and FB connections were expected for sources that displayed priming effects in their source waveforms. Hence, neural sources in each hemisphere were fitted with either F or FB connections. Inter‐hemispheric connections were considered between homologous areas and were allowed to be modulated in an incremental manner resulting in a model space that comprised of 24 models. Bayesian model averaging across models revealed effective bidirectional connectivity between the Fusiform Gyrus (face perception) and Prefrontal Cortex (decision‐making) in both hemispheres to be modulated by priming. In the left hemisphere, there is also a substantial involvement from the Mediotemporal Lobe, indicating the facilitation of automatic retrieval of the famous person's name. Furthermore, there is evidence that the priming is supported by connections from the right to the left Fusiform Gyri possibly in the service of inter‐hemispheric cooperation. Altogether, the study indicates that along with top–down modulations, efficient processing within and across the two hemispheres is crucial for famous face priming.