bluuebunny/crossref_metadata_2025_split huggingface dataset:
(111) SAFETY OF AN ELASTOMER-BASED HOOK-AND-LOOP CONFIGURATION “SMART” PENILE CONSTRICTION DEVICE WORN OVERNIGHT AKA: IS IT OK TO FALL ASLEEP WITH THIS COCKRING?
Authors: Winter A , Gross K , Dubin J , Justin E 
Published: December 2024

Abstract

Introduction
Penile constriction devices are commonly used for the management of erectile dysfunction, climacturia, and general sexual performance enhancement, as a stand-alone or multimodal therapy. One common concern is that prolonged utilization of a penile constriction device can lead to difficulty with device removal, penile injury, and potentially penile necrosis.

Objective
With traditional penile constriction devices, there is no way to objectively monitor safety or aggregate user experience data. We hypothesize that a novel elastomer based hook-and-loop configuration cock ring is safe for use overnight, and that biometric sensors embedded in the device can document spontaneous nocturnal erections- thereby confirming presence of blood flow to the penis hours into wear.

Methods
A novel elastomer-based hook-and-loop configuration penile constriction device with embedded pressure sensors was worn by participants in a home environment. Recordings of erection rigidity and duration were uploaded to participants’ smart-phone app via Bluetooth, and data was centrally aggregated by the app engineering team. Subjective reports of user experience were aggregated via narrative input.

Results
5204 unique recordings were obtained over a 14 month period. Mean duration of recording was 6.57+/-3.92 hours. 2700 recordings were greater than 4 hours in duration, with an average 3.09+/-1.62 erections per recording. There were no reports of priapism or dermatitis reported across all users. Two users noted discomfort after &gt;4 hours of use, but they were able to release the device without difficulty.

Conclusions
A biometric sensor enabled “smart” cockring, composed of elastomer in a novel hook-and-loop configuration was worn &gt;5000 individual times with an average duration of &gt;6 hours of wear. There were no significant adverse events, and multiple erections were documented for users who kept the device on for &gt;4 hours, indicating physiologic blood flow to the penis. To our knowledge, this is the first penile constriction device to have proven safety with overnight use.

Disclosure
Yes, this is sponsored by industry/sponsor: FirmTech.
Clarification: Industry initiated, executed and funded study.
Any of the authors act as a consultant, employee or shareholder of an industry for: FirmTech.
(125) BASAL RELEASE OF 6-CYANODOPAMINE FROM RAT ISOLATED VAS DEFERENS AND ITS ROLE ON THE VAS DEFERENS CONTRACTILITY
Authors: Sanches Dal Pozzo CF , De Nucci G , Britto-Júnior J , Agostini Badin JF , Fragonesi A , Lorenzon F 
Published: December 2024

Abstract

Introduction
6-Cyanodopamine is released from isolated rabbit heart and is a novel endothelial catecholamine similar to 6-nitrodopamine described by our research group. 6-Nitrodopamine is a major endogenous modulator of human vas deferens contractility. However, it is not known whether 6-cyanodopamine presents any biological activity.

Objective
Here it was evaluated whether 6-cyanodopamine was released from rat isolated vas deferens and wether, like 6-nitrodopamine, modulates vas deferens contractility.

Methods
The basal release of 6-bromodopamine, 6-nitrodopa, 6-nitrodopamine, 6-cyanodopamine, and 6-nitroadrenaline from the vas deferens was quantified using LC–MS/MS. Electric-field stimulation (EFS) and concentration-response curves for noradrenaline, adrenaline, and dopamine were performed on the rat isolated epididymal vas deferens (RIEVD) in the absence and presence of 6-cyanodopamine. The expression of tyrosine hydroxylase and S100 was assessed by immunohistochemistry. Additionally, we evaluated the effect of tetrodotoxin on the release and effect of 6-cyanodopamine in the rat vas deferens. The synergism between 6-cyanodopamine and 6-nitrodopamine was analyzed in the RIEVD.

Results
The rat isolated vas deferens release both 6-cyanodopamine and 6-nitrodopamine. Pre-incubation with tetrodotoxin, had no effect on the release of 6-cyanodopamine, but it virtually abolished 6-nitrodopamine release. 6-Cyanodopamine contracted RIEVD only at 1 mM, but significantly potentiated the contractions induced by both noradrenaline and EFS at 1 nM. At 10 and 100 nM, 6-cyanodopamine also significantly potentiated the RIEVD contractions induced by adrenaline and dopamine. The potentiation of both noradrenaline and adrenaline contractions by 6-cyanodopamine was present in tetrodotoxin-pretreated tissues. Co-incubation of 6-cyanodopamine (100 pM) with 6-nitrodopamine (10 pM), caused significant leftward shifts and increased maximal responses of the concentration-response curves to noradrenaline, even in the presence of tetrodotoxin. Immunohistochemistry on RIEVD revealed the presence of tyrosine hydroxylase in both the cytoplasm of epithelial cells of the mucosae and in the nerve fibers.

Conclusions
The identification of the basal release of epithelium-derived 6-cyanodopaine from rat isolated vas deferens and its remarkable ability to potentiate noradrenaline- and EFS induced contractions of this tissue, demonstrate that epithelial cells modulate smooth muscle contractility.

Disclosure
No.
(129) TECHNICAL ASPECTS OF THE PENILE IMPLANT IN THE TRANSGENDER MALE PATIENT
Authors: Hendges LP , Martinez-Fernandez A , Vishwakarma R , Maiolino G , Fernández-Pascual E , Lledó-Garcia E , Martinez-Salamanca JI 
Published: December 2024

Abstract

Introduction
The surgery for the penile prosthesis in transgender male patients with neophallus is technicaly challenging. The absence of native penile structures and the presence of a single vascular pedicle for the neophallus vascularization, usually are factors that stand against the prosthetic surgeon. Thefore, the complication rate of this procedures generally are higher than the cisgender patient.

Objective
The ain of this abstract is to elucidate and standardize the surgical steps of this procedure using are experience with the new prosthesis models specifically designed for the transgender male patient.

Methods
We overview, the surgical steps, and nuances, of the penile prosthesis in the transgender male patient. We show 2 surgical cases using the inflatable prosthesis (ZSI 475 FTM) and the malleable prosthesis (ZSI 100 FTM) both designed for the neophallus. We surgically standardized the technique utilizing an infrapubic aproach, on the contralateral side of the vascular pedicle. We performe the neophallus dilatation leaving 1 cm of fat pad above the dilation tunel, and 2 cm above de glans skin, to possbility a natural aspect and avoid a superficial location of the implant. The proximal aspect of the prosthesis are fixated on the pubic bone. In the inflatable prosthesis, the pump is placed in the neoscrotum and simulate a testicle prosthesis. The resorvoir is placed in the Retzius Space as in the infrapubic aproach in the cismale patients.

Results
The patients did not report any complications and are fully satisfied with the implant.

Conclusions
The surgical aspects of the technique for the penile prosthesis in the transgender male patient, despite defying, if standardezed could be the way to decrease the complication rate in this tipe of surgery. The newest prosthesis models assists to improve the surgicals outcomes, and patient satisfaction.

Disclosure
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(133) ERECTILE DYSFUNCTION IN MEN UNDERGOING HEMODIALYSIS FOR CHRONIC KIDNEY DISEASE IN A CITY IN THE BRAZILIAN AMAZON
Authors: De Barros Neto J , Afonso Teixeira T , Rocha Lopes G , Santos Almeida HK , Prado Dantas HV , Garcia De Azevedo ME , Tenório Da Silva F , Dias Rocha K , Tiyomi Sacata Tongu Nazima M 
Published: December 2024

Abstract

Introduction
Erectile dysfunction (ED) is a prevalent sexual issue that affects men with chronic kidney disease (CKD). The degree of sexual dysfunction generally worsens with the progression of CKD.

Objective
we assessed the erectile function and sexual quality of life of adult male CKD patients who undergo hemodialysis (HD) in a hospital situated in the Brazilian Amazon.

Methods
A cross-sectional quantitative study was conducted in the HD Sector of the Nephrology Unit. The study included men with CKD who were 18 years of age or older and had been sexually active for at least six months. These men underwent three weekly HD sessions for three months. To measure sexual satisfaction, we used the Male Sexual Quotient (MSQ). We also used the International Index of Erectile Function (IIEF5) to assess erectile function. We performed statistical analysis with SPSS 21.0, utilizing appropriate tests such as Mann–Whitney and Kruskal-Wallis (P &gt; 0.05).

Results
Ninety-eight patients with an average age of 51.68 ± 15.28 years were evaluated. Most were married or in a relationship (60.20%), had been receiving HD treatment for 1 to 5 years (55.10%), and had an average KTV of 1.17. The prevalence of ED was found to be 66.30%. It was observed that ED was more common in older patients (p = 0.01), those with lower family income (p = 0.02), diabetes (p = 0.01), lower mean corpuscular hemoglobin (p = 0.04), higher total calcium (p = 0.04), and lower albumin (p = 0.03). Around 75% of patients rated their sexual life as regular to excellent.

Conclusions
Despite a high prevalence of ED, men with CKD undergoing HD reported regular to excellent sexual function. The study emphasizes the importance of screening and routine evaluations for sexual issues in these patients.

Disclosure
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(187) OBSTRUCTED HEMIVAGINA AND IPSILATERAL RENAL ANOMALY (OHVIRA) SYNDROME: CASE SERIES
Authors: Monteiro Filho M , Nacle L , Ciriaco M , Monteiro P , Bruno Z 
Published: December 2024

Abstract

Introduction
Obstructed Hemivagina with Ipsilateral Renal Anomaly (OHVIRA) syndrome, also known as Herlyn-Werner-Wunderlich syndrome, is a rare anomaly of the female genitourinary tract characterized by the triad of uterus didelphys, an obstructed vagina due to an oblique vaginal septum, and ipsilateral renal agenesis. Affected women may present with cyclic pelvic pain, dysmenorrhea, and/or hematocolpos a few years after menarche.

Objective
To describe the similarities and particularities of patients with OHVIRA syndrome followed in a specialized outpatient clinic of a tertiary university hospital.

Methods
Retrospective, cross-sectional, and quantitative study based on the review of medical records from November 2016 to April 2024. The collected data were organized in a spreadsheet and presented as mean, number, and percentages.

Results
Fourteen patients with OHVIRA syndrome were identified, who had menarche at an average age of 10.8 years, except for one patient who had not yet had menarche at the time of data collection. After the first menstruation, an average of 11 months elapsed before the onset of pelvic pain. Consistent with the natural history of the syndrome, all patients were diagnosed during childhood or adolescence, with an average age of 12.7 years, the youngest being diagnosed at seven and the oldest at 16. Of the 14 patients followed, 10 underwent vaginal septoplasty an average of 14.4 months after menarche. Of these, only one required a second septoplasty to ensure vaginal patency, six months after the first procedure. Only one patient, who had a four-year interval between menarche and diagnosis, developed endometriosis.

Conclusions
Progressive dysmenorrhea complaints at the beginning of reproductive life should not be minimized and warrant appropriate investigation. The diagnosis of OHVIRA syndrome is low-cost and easily accessible, as it is made through clinical examination and ultrasonography. Besides diagnosis, timely intervention is essential to avoid sequelae resulting from vaginal obstruction, such as endometriosis and chronic pelvic pain. Therefore, the identification of the clinical triad and early approaches can significantly impact the quality of life of patients with this condition.

Disclosure
No.
(193) EPIDEMIOLOGICAL CHARACTERISTICS OF ERECTILE DYSFUNCTION IN THE BRAZILIAN POPULATION: A CROSS-SECTIONAL STUDY
Authors: Noffs Motta S , Yoneyama Mourthé E , Rocha Chavez Zambrana D , Victor Fonseca Ribeiro J , Nardozza Junior A , Rhein Felippe M , Iasmin Lima Lemos C , Eli Girotti M , Brandão Vasco M 
Published: December 2024

Abstract

Introduction
Erectile dysfunction (ED) is a common symptom among men with cardiovascular diseases and various disorders, including hypogonadism, Peyronie’s disease, priapism, neuralgic disorders, and depression, as reported by the American Institute of Health. The presence of these conditions serves as risk factors for the development of ED, prompting men to seek medical attention when they detect changes in erectile function, thereby signaling potential underlying health issues. Understanding the link between these conditions and ED is crucial for effective management and intervention.

Objective
This study aims to investigate the epidemiological profile of men diagnosed with erectile dysfunction.

Methods
A retrospective cross-sectional analysis was conducted on patients with erectile dysfunction attending the andrology outpatient clinic at a university hospital. Sociodemographic information, comorbidity profiles, lifestyle habits, addictive behaviors, and other sexual concerns were assessed through a structured questionnaire. The association between sociodemographic variables and comorbidities was evaluated using Fisher’s exact test, with statistical significance set at p &lt; 0.05, and analyzed using the Stata® software.

Results
A total of 654 patients were included in the study, with a mean age of 61.46 ± 12.01 years, and 63.5% of participants aged ≥60 years. The racial distribution showed that 54.6% were white (357/654) and 32.2% were brown (211/654) individuals. Among them, 68.3% (447/654) were married, and 50.9% (333/654) had not completed elementary education. The most prevalent comorbidities were Systemic Arterial Hypertension (51%, 333/654) and Diabetes Mellitus (32.7%, 214/654). Regarding lifestyle habits, 77.1% (504/654) did not use any drugs, while 16.7% (109/654) were smokers. Additionally, 80 patients reported concurrent sexual dysfunctions, with premature ejaculation (33%, 26/80) and Peyronie’s disease (25%, 20/80) being the most common. Smoking was found to have a significant association with ED (p-value = 0.03), whereas no other statistically significant associations were observed in the analyzed variables.

Conclusions
This study highlights that individuals with ED in this population tend to be predominantly white or brown, married, and with lower educational attainment. Systemic Arterial Hypertension and Diabetes Mellitus were the leading comorbidities, and smoking showed a significant association with ED. These findings underscore the importance of comprehensive assessment and management strategies for ED patients, taking into account their sociodemographic and lifestyle factors.

Disclosure
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(219) SUCCESSFUL HANDLING OF VAGINISM BY HYPNOSIS
Authors: Csiby A 
Published: December 2024

Abstract

Introduction
The clinical demonstration describes the treatment of vaginism - vaginism occuring before and during a gynecological examination - with hypnosis. The 33-year-old female patient had been suffering from continuous lower abdominal pain for 3 years. Endocrinological and laboratory tests showed negative results. A gynecological and a vaginal ultrasound examination were necessary to rule out or diagnose endometriosis, however the vaginism that occurred during the examinations and the intense anxiety that appeared in the doctor’s consulting room, did not allow the examination. After 9 unsuccessful gynecological examinations, the patient turned to a psychologist on the advice of a psychiatrist.

Objective
The objective was to cure the vaginism of the patient who has been suffering by it for 3 years and visited 9 gynachologist to have the examination.

Methods
After uncovering the background of the anxiety, we used systematic desensitization in hypnosis.

Results
Psychological consultations and sessions of hypnosis made it possible to perform a vaginal ultrasound examination and establish the source of the somatic symptom.

Conclusions
The case points to the possibility that a somatic complaint related to sexuality that has existed for years can be successfully treated with hypnosis.

Disclosure
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(227) PRELIMINARY DATA ON THE USE OF PLATELET RICH PLASMA ON PENIS FOR ERECTILE DYSFUNCTION
Authors: Mayer M , Valente S , Gioielli A 
Published: December 2024

Abstract

Introduction
Erectile dysfunction (ED) is the persistent or recurrent inability to achieve and/or maintain a penile erection sufficient to maintain satisfactory sexual encounters. For correct function, the erectile mechanism requires the integrity of the participating neurological, psychological, vascular, mechanical and hormonal components. Any impairment of any of these components can make it difficult to develop and maintain an erection. Vasculogenic ED is the main cause of organic ED and it is a disorder that is manifested by reduced penile blood flow, arterial insufficiency or stenosis, as well as endothelial dysfunction. The use of platelet-rich plasma (PRP) in multiple medical specialties is already known internationally. Its mechanism of action is at the cellular level, increasing its number (mitogenesis) and stimulating angiogenesis through multiple growth factors and cytokines that can affect inflammation, angiogenesis and proliferation. Different studies show that PRP injections can modify key pathophysiological mechanisms that lead to erectile dysfunction through reparative, anti-inflammatory, neuroprotective and neurotrophic effects. There is evidence that PRP treatment could induce a functional effect in the cavernous tissue in addition to the declared restorative/regenerative effect.

Objective
To evaluate the effects of acute exposure to autologous PRP as a therapeutic strategy in patients with erectile dysfunction of mild–moderate.

Methods
Patients with erectile dysfunction (ED) of mild–moderate calculated by IIEF 5 questionnaire, with incomplete response to IPD5 inhibitors, were selected and 4 doses of autologous PRP were applied to the penis. All the patients signed an informed consent prior to each application.

Results
The average age of the patients was 67.2 years (range 55-81). The IIEF-5 average prior to applications was 15.6. One month after having finished the complete protocol, the IIEF-5 score showed a result of 19.9. All the patients who received PRP were more satisfied with the PRP treatment with the achieved erection. No adverse effects were observed during the study period.

Conclusions
Our results support the clinical improvement of PRP treatment to IPDE5 response. Furthermore, as it is an autologous treatment, without relevant complications and at a low cost, it could be a non-dismissable strategy for patients with ED of mild–moderate vascular origin.

Disclosure
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(231) THE SENSATE FOCUS TECHNIQUE EVALUATION IN TREATING VAGINISMUS
Authors: Fejza H , Icka E , Kraja-Bardhi E , Alidema F 
Published: December 2024

Abstract

Introduction
Vaginismus is poorly understood and relatively unknown among healthcare providers. It can cause distress, relationship problems, and also infertility. Many treatments have been tried including sex therapy, education, hypnosis, and drug treatments.

Objective
The study aimed to present the effects of the sensate focus technique in treating vaginismus and the success rate in our clinic.

Methods
The treatment included a weekly session, each of 45 minutes duration, based on the components of the sensate focus technique to improve communication and fortify relationships, along with step-by-step learning of sexual relations, counseling and education about the anatomical and psychological basis of vaginismus for both partners. The study includes 62 cases of vaginismus treated in the Specialized Clinic of Clinical Sexology- Libido in Pristina, Kosovo, during the period of, October 2019- March 2024.

Results
Sensate focus techniques usually include three sessions, but in our cases, we treated some patients longer. In 29% of cases, the problem was solved by 1-3 sessions, while 43% were in 3-5 sessions. Cases mainly with degrees 4 and 5 of vaginismus were treated in more than 5 sessions.

Conclusions
The sensate focus technique is the most appropriate method for solving problems with vaginismus. Taking into consideration the predisposing and maintenance factors, the information and advice given by this method make changes in beliefs and behaviors during sexual activity.

Disclosure
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(237) TRANSLATION, SEMANTIC EQUIVALENCE, AND CULTURAL ADAPTATION OF THE SEXUAL INTERVENTION SELF-EFFICACY
Authors: Finotelli Junior I 
Published: December 2024

Abstract

Introduction
Sexuality matters and is a mental health indicator. Awareness of sexual studies has expanded, overcoming misconceptions and underestimating their social impact. Global research shows that the issue goes beyond bias due to poor education and post-college training. Few English-language and culturally limited measures assess professionals competency on these issues.

Objective
This study aims to translate and culturally adapt the Sexual Intervention Self-Efficacy Scale to Brazilian Portuguese. It’s an initial step toward a national scale aligned with Brazilian academic and legal standards.

Methods
This 19-item scale was designed to assess self-efficacy beliefs regarding the ability to address clients’ sexual concerns/problems in a clinical setting. The items are measured on a Likert scale, with responses ranging from “strongly disagree” to “strongly agree”. The process engaged twelve sexuality specialists with over 15 years of experience, and a convenience sample of 60 individuals assessed intelligibility. The stages included translation, back-translation, evaluation of semantic-equivalence, final review by experts, and pre-test version.

Results
Assessing semantic equivalence demonstrated substantial agreement among judges, ranging from strong to perfect. The expert review updated the technical terminology, as the scale was created over 10 years ago, and modified the item about concerns to address discomfort, not exclusively related to discussing masturbation. There were no significant considerations in the applications conducted in the pre-test version.

Conclusions
The findings presented a version that was extremely intelligible and placed significant emphasis on updating technical terms. It has the potential to serve as a screening tool to identify topics that need to be developed by professionals. This version kept the scales name in English but added “Brazilian Adaptation” in Portuguese at the end.

Disclosure
No.