bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody–positive Dermatomyositis-associated Interstitial Lung Disease
Authors: Fujisawa Tomoyuki , Hozumi Hironao , Yasui Hideki , Suzuki Yuzo , Karayama Masato , Furuhashi Kazuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Suda Takafumi 
Published: May 2019

Objective.To assess prognostic factors of antimelanoma differentiation-associated gene 5 antibody (anti-MDA5)–positive dermatomyositis/clinically amyopathic DM–associated interstitial lung disease (DM/CADM-ILD) and evaluate the use of serum chitotriosidase, a marker for macrophage activation, as a potential biomarker in anti-MDA5-positive DM/CADM-ILD.Methods.This retrospective study included 30 patients with anti-MDA5–positive DM/CADM-ILD. The clinical characteristics and laboratory findings at the time of diagnosis were analyzed. Serum chitotriosidase levels were measured in the 30 patients, in 21 healthy controls, and in 25 patients with anti-aminoacyl-tRNA synthetase antibody–positive (anti-ARS)-polymyositis (PM)/DM/CADM-ILD, and the potential of serum chitotriosidase as a prognostic biomarker in anti-MDA5–positive DM/CADM-ILD was assessed.Results.The median serum chitotriosidase level in patients with anti-MDA5–positive DM/CADM-ILD was 17.3 ng/ml, which was higher than that in healthy controls and anti-ARS–PM/DM/CADM-ILD (2.0 and 8.9 ng/ml, respectively). Of the 30 patients, 10 died of respiratory failure associated with DM/CADM-ILD deterioration. Cox hazard analysis demonstrated that higher serum chitotriosidase level and lower PaO2 value were significant predictors of a poor outcome. Using optimal cutoff levels according to receiver-operating characteristic curve analyses, chitotriosidase ≥ 23.5 ng/ml, ferritin ≥ 800 ng/ml, and Krebs von den Lungen–6 ≥ 720 U/ml were significantly associated with a poor prognosis. Serum chitotriosidase levels were negatively correlated with PaO2 and percentage predicted forced vital capacity. The survival rate was significantly poorer in patients with high chitotriosidase levels (≥ 23.5 ng/ml) than in those with low chitotriosidase levels (< 23.5 ng/ml).Conclusion.Serum chitotriosidase may be a potential biomarker for predicting a poor prognosis in patients with anti-MDA5–positive DM/CADM-ILD.
Improving Scoring Precision and Internal Construct Validity of the Bath Ankylosing Spondylitis Disease Activity Index Using Rasch Measurement Theory
Authors: Heaney Alice , McKenna Stephen P. , Hagell Peter , Sengupta Raj 
Published: May 2019

Objective.To test the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) according to Rasch Measurement Theory and investigate whether measurement precision can be improved.Methods.Secondary analysis of a BASDAI database. The data had been collected from individuals starting an Ankylosing Spondylitis Exercise Course at the Royal National Hospital for Rheumatic Diseases in Bath, UK.Results.Data were available for 250 participants (23.6% female) aged between 18 and 85 years (mean 52.8, SD 14.6). Initial fit of the data to the Rasch model appeared good and item thresholds were consistent, but local item dependence (LID) was identified. After addressing the LID, a unidimensional measure was achieved. The Person Separation Index (reliability) was 0.83 and the location of the items was well matched to that of the respondents. A transformation table was generated to convert total raw BASDAI scores into linearized Rasch transformed scores that form an interval scale. The Smallest Detectable Difference improved from 2 to 1.2. This finding suggests that a change score of > 1.2 points on the modified BASDAI is required to achieve meaningful change.Conclusion.Applying the Rasch transformed scores simplifies completion and scoring of the measure and confirms internal construct validity. It also ensures linear measurement and justifies the use of parametric statistical analyses when analyzing datasets. The transformation table can be used with existing BASDAI datasets to allow direct comparisons of disease activity scores with those generated from future studies.
Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis
Authors: Bruschi Maurizio , Bonanni Alice , Petretto Andrea , Vaglio Augusto , Pratesi Federico , Santucci Laura , Migliorini Paola , Bertelli Roberta , Galetti Maricla , Belletti Silvana , Cavagna Lorenzo , Moroni Gabriella , Franceschini Franco , Fredi Micaela , Pazzola Giulia , Allegri Landino , Sinico Renato Alberto , Pesce Giampaola , Bagnasco Marcello , Manfredi Angelo , Ramirez Giuseppe A. , Ramoino Paola , Bianchini Paolo , Puppo Francesco , Pupo Francesca , Negrini Simone , Mattana Federico , Emmi Giacomo , Garibotto Giacomo , Santoro Domenico , Scolari Francesco , Ravelli Angelo , Tincani Angela , Cravedi Paolo , Volpi Stefano , Candiano Giovanni , Ghiggeri Gian Marco 
Published: May 2019

Objective.Neutrophil extracellular traps (NET) expose modified antigens for autoantibodies in vasculitis. Little is known about levels and removal pathways of NET in systemic lupus erythematosus (SLE), especially in lupus nephritis (LN). We determined circulating levels and defined NET removal in large subsets of patients with incident SLE (iSLE), some of whom had new-onset nephritis.Methods.Serum levels of NET (ELISA), DNase1/DNase1L3 (ELISA), and DNase activity (functional assay) were determined in 216 patients with iSLE [103 had incident LN (iLN)], in 50 patients with other primary glomerulonephritis, and in healthy controls.Ex vivoNET production by neutrophils purified from a random selection of patients was quantified as elastase/DNA release and by immunofluorescence techniques.Results.Serum NET levels were very high in iSLE/iLN compared to all groups of controls and correlated with anti-dsDNA, C3–C4, and proteinuria; iLN had the highest levels. DNase activity was decreased in iLN compared to SLE (20% had one-half DNase activity) despite similar serum levels of DNase1/DNase1L3. In these cases, pretreatment of serum with protein A restored DNase efficiency; 1 patient was homozygous for a c.289_290delAC variant ofDNASE1L3.Ex vivoNET production by neutrophils purified from LN, SLE, and normal controls was similar in all cases.Conclusion.Patients with iLN have increased circulating NET and reduced DNase activity, the latter being explained by the presence of inhibitory substances in circulation and/or by rareDNase1L3mutations. Accumulation of NET derives from a multifactorial mechanism, and is associated and may contribute to disease severity in SLE, in particular to renal lesions. (Clinical trial registration: The Zeus study was registered atClinicalTrials.gov, study numberNCT02403115).
« N’hommer » : nomination et transmission
Authors: Koren Daniel 
Published: May 2019

Ce texte interroge les conséquences de la nomination (et plus particulièrement de la « non-nomination ») sur le devenir subjectif, ancré dans la dimension de l’histoire familiale. L’auteur évoque plusieurs situations cliniques sur lesquelles il prend appui afin de faire entendre ce qu’il en est de ce point sensible.
Anonymat, sujet du discours et passion pour le vrai
Authors: Cantillon Alain 
Published: May 2019

Les éditeurs des Pensées-de-Pascal en 1776 puis, plus encore, en 1778, ne se contentent pas de demeurer anonymes : ils développent de complexes jeux pratiques et théoriques de l’anonymat qui permettent de produire deux éditions qui critiquent profondément et renouvellent celle de 1669-1670 en l’absence même de tout travail philologique sur les autographes. L’anonymat est poussé si loin qu’il fait apparaître un sujet de l’énonciation clivé, « passionné pour le vrai », adéquat à la forme singulière d’inachèvement fragmenté de cet écrit pascalien.
On sort donc les tripes petit à petit
Authors: Houdart Sophie , Pavy Mélanie 
Published: May 2019

Dans la petite ville de Tôwa, préfecture de Fukushima, au Japon, à une cinquantaine de kilomètres de la centrale nucléaire éponyme, les habitants sont restés vivre après qu’une catastrophe, en mars 2011, a modifié substantiellement la composition de leur environnement. Un tremblement de terre de magnitude 9 au large des côtes du Tôhoku a déclenché un tsunami qui a causé plus de 18 000 morts et disparus et engendré un accident nucléaire de niveau 7. Le panache radioactif échappé des réacteurs endommagés s’est étendu jusqu’à plus de 100 km, créant des poches de contamination aléatoires sur le territoire. Criblée de ces « taches de léopard », la vallée de Tôwa n’a pas été jugée suffisamment contaminée, toutefois, pour qu’une évacuation de la population ait été envisagée. Composé à deux voix, sur la base d’une enquête partagée, ce récit tente de restituer les bribes d’expériences de vie diffractées dans ce territoire incertain.
Relationships among walking speed, selected clinical symptoms, and exercise self-efficacy in individuals with knee osteoarthritis
Authors: Ogwumike Omoyemi O. , Musa Sumayyah Bamidele 
Published: May 2019

PurposeOsteoarthritis (OA) is characterised by a combination of joint symptoms and signs stemming from defects in the articular cartilage and adjacent tissues, such as bone, synovial joint capsule, muscles, and ligaments. Knee OA is among the most common causes of pain and disability in middle-aged and older people. This study investigated the relationships among selected clinical symptoms (pain, stiffness, physical function), walking speed, and exercise self-efficacy in individuals with knee OA in Ibadan, Nigeria.MethodsThe study involved 100 individuals diagnosed with knee OA. Exercise self-efficacy was assessed with the exercise self-efficacy scale. Pain, stiffness, and physical function were evaluated with the Western Ontario and McMaster (WOMAC) Osteoarthritis Index questionnaire. Walking speed was determined during the 20-meter walk test. Data were analysed with descriptive statistics and Pearson’s correlation test, with significance level set at 0.05.ResultsSignificant correlations were observed between pain intensity and walking speed (ρ = –0.38), stiffness and walking speed (ρ = –0.19), physical function and walking speed (ρ = –0.40), pain intensity and exercise self-efficacy (ρ = –0.43), stiffness and exercise self-efficacy (ρ = –0.46), physical function and exercise self-efficacy (ρ = –0.41). More than 50% of the participants with knee OA had low exercise self-efficacy and moderate walking speed. Individuals with higher levels of pain, stiffness, and functional limitations showed lower levels of exercise self-efficacy and lower walking speed.ConclusionsIndividuals with knee OA presented low exercise self-efficacy, low walking speed, and reduced physical function, probably because of the debilitating effects of the condition.
The Polish adaptation of the Five-Factor Obsessive-Compulsive Inventory – Short Form (FFOCI-SF): A preliminary study
Authors: Kłosowski Marcin , Cieciuch Jan , Strus Włodzimierz 
Published: May 2019

BackgroundThe Five-Factor Obsessive-Compulsive Inventory – Short Form (FFOCI-SF) is an instrument used to measure obsessive-compulsive personality disorder, which is one of the most widespread personality disorders. The FFOCI-SF is a shorter version of the FFOCI that was developed on the basis of the Five Factor Model of per-sonality treated as a general framework for identifying different traits useful in describing maladaptive person-ality. This paper presents the psychometric parameters of the Polish adaptation of the FFOCI-SF.Participants and procedureOur sample consisted of 328 respondents aged 18-75 (61% women) from Poland. The voluntary and anony-mous procedure consisted of completing inventories in a self-reported, paper-and-pencil way. The respondents received the FFOCI-SF, the Personal Inventory for DSM-5 (PID-5) and the Big Five Inventory-2 (BFI-2).ResultsThe findings suggest that there is acceptable internal consistency for most of the scales and some problems with the differentiation between some scales in factor analysis. Additionally, we present the hierarchical struc-ture of the facets included in the instrument with two factors analogous to the metatraits of personality (Alpha and Beta). The criterion validity of the inventory was established by correlations on the one hand with Big Five traits (BFI-2) and on the other hand with another measure of the obsessive-compulsive personality disorder traits, namely appropriate scales from the Personality Inventory for DSM-5 (PID-5).ConclusionsThis study confirms that the FFOCI-SF is a valid measure for scientific purposes. In order to use it for diagnostic purposes, further research is suggested on clinical samples. The findings also suggest that the FFOCI-SF can be useful in exploring new solutions in structure of the obsessive-compulsive personality disorder facets.
Over ‘caritas’ en de belofte van de ‘juiste intentie’
Authors: Verweij Désirée 
Published: May 2019

AbstractOn ‘caritas’ and the promise of ‘right intent’Back to the roots of justice in warIn classical Just War texts, the criterion of ‘right intent’ is considered a key concept with regard to the justice of a war as such, since it refers to the basiciustusdisposition from which the other criteria (ad bellumas well asin belloandpost bellum) should be applied. However, in current JW debates, determined to a large extent by Traditionalists and Revisionists, the importance of this key concept threatens to disappear from view. This article aims to show the relevance of further reflection on the role and meaning of the criterion of ‘right intent’ using classical JW insights and in particular Hannah Arendt’s analysis of Augustine’s concept of ‘caritas’, given the political relevance of this concept as pointed out by Arendt. The criterion of ‘right intent’ is closely connected to Arendt’s distinction between power and violence and her principle of the right to have rights. Right intent, as a virtue, based on and inspired by caritas, in more contemporary discourse, a humanitarian ethos, implies the promise of theiustusapplication of the JW criteria that were originally formulated precisely for that reason.
A Viable Option for Dictionary Pronunciation Guides
Authors: Buck-Gengler Carolyn J. , Healy Alice F. 
Published: May 2019

Abstract
English words do not always follow simple letter-to-sound pronunciation rules, and thus readers sometimes need to look up a pronunciation of an unfamiliar word, especially in the case of children and foreign learners of English. Pronunciation guides in dictionaries take many forms. The most common guides in American dictionaries use diacritics over many of the vowels to indicate different pronunciations. We compared a commonly used diacritic system with an alternative system that uses only the 26 letters used in English. We found that the alternative system was easier for participants to learn and use to respond with the correct English spelling of a target word given the spelling from the pronunciation guide. We conclude that when dictionary makers want to find a simpler system than one with diacritics, a system such as the one tested here should be considered.
“As Much Right to Live in a House as Anybody”: Black Women and the Fight for Housing Integration in the 1940s
Authors: Gonda Jeffrey D. 
Published: May 2019

AbstractThis article examines Black women’s roles within the legal campaign against racial restrictive covenants in private housing during the 1940s with a particular focus on local litigation in the years before Shelley v. Kraemer (1948). Through a critical reading of case records, private correspondence, oral histories, and press accounts, this article argues that women played an essential and largely unacknowledged role in the development of the anticovenant campaign by serving as pioneering homebuyers, litigants, and community mobilizers in support of legal cases. Further, it analyzes how gender, as much as race, shaped the substance of Black women’s experiences and contributions in the processes of litigation and gave unique contours to a resurgent rights consciousness in the wartime and immediate postwar period. By moving beyond a biographical approach to the study of women’s roles in the movement’s legal sphere and concentrating on the impact of gender at a critical inflection point in the 1940s, the article addresses an important gap in legal histories of the civil rights movement.1
Comparison of Serum Biochemical and Haematological Analyses in Patients with Age-Related Macular Degeneration and Diabetic Retinopathy
Authors: Akdogan Muberra , Ustundag Yasemin , Sabaner M. Cem , Dogan Mustafa 
Published: May 2019

We evaluated biochemical analysis results with the aim of discovering serum levels that have possible effects and differences on age-related macular degeneration (AMD) and diabetic retinopathy (DRP).
A retrospective case-control study was conducted between January 2017 and January 2018 on a total of 114 patients (84 DRP, 30 AMD) and 24 age and sex-matched control individuals. Four groups were created; 52 patients with proliferative DRP (PDR), 32 patients with nonproliferative PDR (non-PDR), 30 patients with wet AMD and 24 control individuals. Serum biochemical (HbA1C, fasting glucose, AST, ALT, C-reactive protein, albumin, total protein, uric acid, triglyceride, HDL, LDL, total cholesterol, Na, K, urine albumin) and complete blood count (CBC) analyses were performed at the time of diagnosis. Descriptive statistics, one-way ANOVA and Kruskal-Wallis tests were performed using SPSS to analyse data (Version 22.0).
The mean age of patients was 63.3 years ± 6.4 (49-91year), and that of control individuals was 65.3 years ± 9.3 (50-88 year). Post hoc analysis showed statistically significant differences in HbA1c and fasting glucose levels among PDR-AMD, PDR-control, non-PDR-AMD, and non-PDR-control groups (whole, P
Un marco de referencia para las Enseñanzas Artísticas Visuales en dispositivos móviles
Authors: Ramón Verdú Alfredo José , Cuervo Pando Alfredo , Ruiz Llamas María Gracia 
Published: May 2019

La irrupción de los dispositivos móviles en el proceso de enseñanza-aprendizaje en educación, acaecido en los últimos años, ha permeado en todos los sectores educativos, y consecuentemente, ha requerido la incorporación en cada disciplina de nuevas metodologías de trabajo, o la adecuación de las existentes. En todos los casos, la incorporación de esta tecnología está demandando la concreción de estructuras organizativas capaces de adaptase a las potencialidades inherentes de los propios dispositivos móviles, y a los diversos enfoques conceptuales del proceso de enseñanza-aprendizaje.
En el presente trabajo se propone un modelo de estructura para las Enseñanzas Artísticas Visuales que integra las distintas fases y actuaciones necesarias para llevarlo a cabo, manteniendo al alumnado como eje central del proceso. El modelo se fundamenta por un lado, en la definición del escenario de aprendizaje, de la planificación estratégica, y de la fase operativa, y por otro lado en los contextos y los espacios de trabajo desde los que organizar las formas de intervención en las Enseñanzas Artísticas Visuales. Como resultado, el diseño de la instrucción de los dispositivos móviles, determina la planificación de las acciones en espacios de aprendizaje autónomo y auténtico, en los que la educación artística visual se desenvuelve. Finalmente se plantea la definición del prototipo, prueba, evaluación, e implementación, de la estrategia en el momento de producción.
The entry of mobile devices into the teaching-learning process in education, occurred during the last years, has permeated all educational sectors, and has consequently required the incorporation in every discipline of new working methodologies or the adjustment of the existing ones. In any event, the incorporation of this kind of technology is demanding the implementation of organizational structures capable of adapting to the inherent potentialities of mobile devices, as well as to the different conceptual approaches in the teaching-learning process.
In this work we propose a model of structure for the Visual Arts Education, which integrates the different phases and the necessary actions to be carried out, while considering learners as the central axis of the process. This model is based, on the one hand, on the definition of the learning setting, the strategic planning and the operational phase, and on the other hand, on the contexts and the working spaces from where the forms of intervention in the Visual Arts Education may be organised. As a final result, the instructional design of the mobile devices determines the planning of the actions in spaces of autonomous and authentic learning in which Visual Arts Education takes place. Finally, we propose the definition of the prototype, the test, the evaluation and the implementation of the strategy at the moment of production.
Analyse typologique des investisseurs participant au financement d’un rachat d’entreprise par son propriétaire : une étude exploratoire1
Authors: Meniaoui Jihène , Ben Larbi Sami 
Published: May 2019

Notre étude cherche à identifier, dans un cadre théorique articulant les approches juridico-financières et cognitives de la gouvernance, le profil-type des investisseurs participant au financement d’un rachat d’entreprise par son propriétaire (owner buy out, OBO). En nous appuyant sur une grille d’analyse regroupant les facteurs explicatifs d’une prise de participation dans le cadre d’un OBO, nous avons procédé à une analyse typologique fondée sur une classification hiérarchique ascendante en deux étapes (two-step cluster analysis).Nos résultats, obtenus grâce à une enquête administrée auprès d’un échantillon de 42 investisseurs financiers spécialisés opérant en France, ont fait émerger deux classes d’investisseurs présentant des caractéristiques clairement différenciées. La différence entre les deux classes est d’ordre disciplinaire et cognitif et concerne essentiellement la perception qu’ont les investisseurs des enjeux stratégiques d’une opération OBO et la nature des indicateurs conduisant à la maîtrise du couple risque/rentabilité caractérisant un tel montage.
Identité fluide dans la correspondance de Zola et la pratique de l’autoportrait
Authors: De Viveiros Geneviève 
Published: May 2019

Zola n’est pas étranger à l’art du portrait : journaliste, il a signé de nombreux textes où il met en scène ses contemporains. La correspondance, parce qu’elle permet l’autoréflexion à travers le dialogue avec l’autre, est également le lieu d’expression chez Zola, de portraits et d’autoportraits. Nous cherchons à montrer, dans notre article, en parcourant différents exemples d’autoportraits accueillis par la correspondance du romancier, comment il se présente comme épistolier. L’identité qu’assume le romancier dans ses lettres est souvent fluide, changeante, dépendante des rapports qu’il entretient avec le monde littéraire. Ceci est surtout vrai en ce qui concerne les échanges épistolaires entretenus avec d’autres acteurs du champ littéraire, écrivains, critiques et journalistes.
De la vie dans son art, de l’art dans sa vie
Authors: Collington Tara 
Published: May 2019

Publié en 2008, le recueil De la vie dans son art, de l’art dans sa vie (Paris, Seuil) reproduit la correspondance entre la comédienne et écrivaine Anny Duperey et la peintre Nina Vidrovitch sur une période de cinq ans, de 1993 à 1998. La présente étude examine d’abord la naissance de cette correspondance et puis la genèse du projet de publication, tout en soulignant quelques aspects formels de l’oeuvre en question. Les deux épistolières abordent une variété de sujets dans leurs échanges, mais un fil conducteur réunit toutes les lettres reproduites dans le livre : la question d’assumer son identité en tant que « femme artiste ». Nous nous penchons sur trois thèmes incontournables de ce recueil : d’abord, la question de la bonne gestion de son image en tant que femme artiste ; ensuite la question de l’imbrication des vies privées et publiques des deux femmes ; et finalement le rapport entre la création artistique et la pratique épistolaire.