bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Awareness in Achieving Marital Satisfaction Among Young Professional Families in Indonesia
Authors: Mas'udah Siti 
Published: December 2024

ABSTRACTGender awareness is considered a significant contributor in determining and impacting marital satisfaction amongst couples and making a strong family. This study explores the role of gender awareness in achieving marital satisfaction among young women professionals residing in Surabaya, Indonesia. The study deployed a qualitative research design, and 56 in‐depth interviews were carried out with women professionals who had been married for less than 5 years. The results show that gender awareness among young professional families varies based on decision‐making. The young women were aware of marital satisfaction about gender roles. There are two groups of women supporting distinctly different ideologies. The first group supports patriarchy, whereas the second group opposes the prevalence of a patriarchal culture. It further seeks to offer novelty in studying gender and marital satisfaction among professional families in Javanese society.
Antibacterial Activity and Action Mechanism of Synthetic Interleukin‐8 Derived Peptides Against Flavobacterium psychrophilum
Authors: Santana Paula A. , Tamayo Laura , Stambuk Felipe , Aguilar Luis Felipe , Cortés Marcos , Guzmán Fanny , Forero Juan Carlos , Romero María Soledad , Álvarez Claudio A. 
Published: December 2024

ABSTRACTIn Chile, Atlantic salmon and rainbow trout face significant production challenges due to the presence of Flavobacterium psychrophilum, which generates severe disease issues and economic losses. To address this, the salmon industry relies on vaccines and antibiotics, the latter raising concerns about bacterial resistance. For that reason, our study explores an alternative strategy for controlling F. psychrophilum infections based on host defence peptides. We previously identified and characterised IL‐8‐derived salmonid peptides (ssIL‐8α and omIL‐8α) with potential antimicrobial properties. In the current study, we further investigated the antibacterial activity and mechanism of action of these peptides against F. psychrophilum. First, we demonstrated the antibacterial activity of ssIL‐8α and omIL‐8α synthetic peptides. Then we evaluated the effects of these peptides on membrane fluidity and localisation on bacterial cells by fluorescence microscopy as well as its impact on bacterial morphology and ultrastructure by electron microscopy. The results indicate that the ssIL‐8α at 30 μM exhibits superior efficacy in inhibiting the growth of F. psychrophilum. Also, both ssIL‐8α and omIL‐8α can bind to pathogen membrane, but ssIL‐8α exhibits a higher binding capacity compared to omIL‐8α against F. psychrophilum. omIL‐8α exhibited the ability to induce early membrane alterations within 15 min, at concentrations of 15 or 30 μM. The SEM and TEM micrographs showed membrane disruption of the bacteria after incubation with ssIL‐8α or omIL‐8α. However, the damage was more pronounced in the ssIL‐8α treatment, as evidenced by a complete detachment of the outer membrane after a 20‐min exposure of F. psychrophilum. This study reveals that these peptides significantly alter bacterial membrane morphology, leading to bacterial death, highlighting their potential as alternative treatments in flavobacterial disease control. This work contributes to understanding host defence peptides' role in combating bacterial infections and reducing antibiotic resistance in aquaculture.
Venous thromboembolism in patients aged ≥90 years: Trends in clinical features, treatment, and outcomes—RIETE registry
Authors: Lafaie Ludovic , Poenou Géraldine , Hanon Olivier , Otálora Sonia , Jiménez Luciano López , Ballaz Aitor , Soler Silvia , Fernández Manuel Jesús Núñez , Bertoletti Laurent , Monreal Manuel ,   the RIETE investigators
Published: December 2024

AbstractBackgroundData on patients aged 90 or older are rare. This study aims to describe clinical characteristics, treatment strategies, and clinical outcomes (rates of VTE recurrence, major bleeding, and mortality), during the first 3 months of anticoagulant treatment for VTE, depending on the treatment period.MethodsWe analyzed data from RIETE, an ongoing global observational registry of patients with objectively confirmed acute VTE, grouped in 5‐year intervals (2004–2008, 2009–2013, 2014–2018, and 2019–2023).ResultsAmong 3477 patients aged 90 or older, clinical characteristics have changed over time (less heart failure, more dementia), with an increase in PE diagnoses from 57% in 2004–2008 to 69% in 2019–2023 (p‐trends <0.001), but of lower severity. For long‐term therapy, there was an increase in patients receiving DOACs (p‐trends <0.001), with a decrease in patients on VKAs (p‐trends <0.001). Mortality and fatal PE respectively showed a temporal trend: 19% and 4% in 2004–2008 to 15% (p‐trends 0.026) and 2% (p‐trends 0.002) in 2019–2023. In multivariable analyses, fatal PE declined from 2004 to 2023 (HR: 0.91; 95% CI: 0.87–0.96). Compared with VKAs, receiving LMWH during the first 3 months of anticoagulation was associated with a higher risk of major bleeding (HR: 1.91; 95% CI: 1.16–3.14) and death (HR: 2.20; 95% CI: 1.71–2.82). The effect seems to be the opposite for DOACs (HR: 0.50; 95% CI: 0.20–1.30 for major bleeding; HR: 0.86; 95% CI: 0.57–1.28 for all‐cause death).ConclusionsFatal PE declined from 2004 to 2023, despite an increase in the diagnosis of PE. Since the arrival of DOACs, there seems to be better management of the therapeutic and diagnostic aspects of VTE in this population, underlining the need for further research on patients aged 90 or older.
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Authors: Kelmer Paz , Hoppa Paulina , Frank Erzsébet , Tyler Teadora , Adorjan Istvan 
Published: December 2024

AbstractSchizophrenia (SCH) is a chronic and serious mental illness which puts an enormous burden on the individual, families, and society. It is well established that altered dopamine signaling and excitatory‐inhibitory imbalance contributes to the symptoms of schizophrenia. Recent neuroimaging and histological studies suggest that the striatum is a key area involved in SCH, however, our knowledge of how specific cell neuronal subtypes of certain subcortical structures may be impaired is incomplete. To this date, no detailed investigation of the putamen has ever been published regarding neuroanatomical changes in SCH. Here we tested whether the density of calretinin immunopositive (CR+) neurons and DARPP32+ neurons is altered in the putamen of patients with SCH. We used immunohistochemistry to reveal CR+ and DARPP32+ neurons in six samples from patients with SCH and six age‐ and gender‐matched control subjects. In line with previous studies, we detected small, medium, and large CR+ neurons. The density of small CR+ neurons was significantly lower in SCH (p = 0.0076). Medium and large CR+ and DARPP32+ neuronal density was not significantly different between groups. The present study substantiates previous results showing significantly lower density of small CR+ interneurons in the caudate nucleus in samples from patients with schizophrenia, highlighting the involvement of the striatum in the disorder. Our results warrant further studies focusing on the role of CR+ interneurons in the regulation of information processing in the fronto‐striatal networks, evidently key structures in schizophrenia.
Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets
Authors: Szabó Florina P. , Sigutova Veronika , Schneider Anna M. , Hoerder‐Suabedissen Anna , Molnár Zoltán 
Published: December 2024

AbstractNeural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons. Developmental disturbances in pyramidal neuron number and function can impede the development of GABAergic neurons, which can have long‐lasting consequences on inhibitory networks. However, the role of deep‐layer pyramidal neurons in instructing the development and distribution of GABAergic neurons is still unclear. To unravel the role of deep‐layer pyramidal neuron activity in orchestrating the spatial and laminar distribution of parvalbumin neurons, we selectively manipulated subsets of layer 5 projection neurons. By deleting Snap25 selectively from Rbp4‐Cre + pyramidal neurons, we abolished regulated vesicle release from subsets of cortical layer 5 projection neurons. Our findings revealed that chronically silencing subsets of layer 5 projection neurons did not change the number and distribution of parvalbumin neurons in the developing brain. However, it did have a long‐term impact on the laminar distribution of parvalbumin neurons and their perineuronal nets in the adult primary motor and somatosensory cortices. The laminar positioning of parvalbumin neurons was altered in layer 4 of the primary somatosensory cortex in the adult Snap25 cKO mice. We discovered that the absence of layer 5 activity only had a transient effect on the soma morphology of striatal PV neurons during the third week of postnatal development. We also showed that the relationship between parvalbumin neurons and the perineuronal nets varied across different cortical layers and regions; therefore, their relationship is far more complex than previously described. The current study will help us better understand the bidirectional interaction between deep‐layer pyramidal cells and GABAergic neurons, as well as the long‐term impact of interrupting pyramidal neuron activity on inhibitory network formation.
Insights into Argentavis magnificens (Aves, Teratornithidae) lifestyle based on neuroanatomy
Authors: Etchegorry Milagros Torres , Degrange Federico J. 
Published: December 2024

AbstractTeratornithidae is an extinct bird family, likely related to Cathartidae, known exclusively from the Americas. They were once thought to be scavengers, but recent theories suggest they were opportunistic or piscivorous birds capable of swallowing prey whole. The most notable species, Argentavis magnificens, had a wingspan of 6 to 8 m and weighed 70 to 80 kg. In order to infer paleobiological aspects of this bird, its endocast (as a proxy for brain morphology), reconstructed from computed tomography scans of the holotype skull, is here described and compared to that of other bird species of zoophagous feeding habits with different flight styles. The brain of Argentavis presents a general appearance similar to that of Cathartidae, being dorsoventrally flattened and anteroposteriorly elongated, with small optic lobes in relation to the total encephalic surface. The estimated volume of the bulbi olfactorii is very similar to that of the Andean Condor Vultur gryphus. The main difference observed with Cathartidae is the marked development of the eminentiae sagittales present in Argentavis (structures closely related to the perception of visual information), which are more similar to those of the Accipitriformes and Falconiformes analyzed. The results obtained here suggest that Argentavis was a scavenger or even maybe a kleptoparasitic bird, relying more on vision than on smell (similar to that observed in the Andean Condor). Furthermore, the inner ear and flocculi exhibit characteristics similar to birds without acrobatic flight, indicating that Argentavis had a soaring flight and inhabited open areas without much vegetation.
Corticosteroid‐responsive narcolepsy type II after COVID‐19: A relevant differential diagnosis of post‐COVID syndrome (a case report)
Authors: Künstler Erika C. S. , Menrad Solveig , Utech Isabelle , Finke Kathrin , Rupprecht Sven 
Published: December 2024

SummaryExcessive daytime sleepiness is a possible symptom of post‐COVID syndrome and is also the cardinal symptom of narcolepsy, a rare life‐long sleep disorder with a possible autoimmune background. Recent reports indicate that COVID‐19 infection may trigger narcolepsy. However, it remains unclear how best to identify and treat such cases. A 25‐year‐old male developed daytime sleepiness after COVID‐19 infection. A diagnosis of narcolepsy type II was made based on pathologically shortened sleep latencies in polysomnography and multiple sleep latency tests (MSLT) together with several sleep‐onset REM‐sleep periods (SOREMs). Pupillography and neuropsychological testing revealed reduced alertness levels. Hypocretin levels in the cerebrospinal fluid were borderline. Based on the postulated autoimmune background of narcolepsy, we performed an intravenous high‐dose corticosteroid pulse therapy with methylprednisolone. Narcoleptic symptoms immediately and consistently remitted after the corticosteroid pulse. Follow‐up after 4 months revealed normalisation of sleep latencies, no further SOREMs in the MSLT, and increased alertness in pupillography and neurocognitive testing. No further wakefulness promoting drug therapy was required. Narcolepsy should be considered in the differential diagnosis of post‐COVID syndrome with leading symptoms of daytime sleepiness. Furthermore, immunosuppressive therapy may offer a treatment option in managing an otherwise lifelong disorder in select cases.
Assessing the psychometric properties of the Biphasic Sleep Scale (BiSS): A novel 16‐item self‐report measure
Authors: Jahrami Haitham , Trabelsi Khaled , Pakpour Amir H. , Ammar Achraf , Husain Waqar , Pandi‐Perumal Seithikurippu R. , Saif Zahra , Seeman Mary V. , Vitiello Michael V. 
Published: December 2024

SummaryBiphasic sleep, characterized by nighttime sleep plus daytime napping, has demonstrated some cognitive, health and performance impacts when compared with consolidated monophasic sleep. This motivated the development and validation of the Biphasic Sleep Scale, reported in this paper. Scale development involved a literature review, expert input and individual interviews. The 16‐item Biphasic Sleep Scale was then administered to an international online sample (n = 6965) alongside well‐established validated sleep scales. To ensure a robust evaluation of the Biphasic Sleep Scale, the sample was divided into two parts: with 15% (n = 1000) of the participants allocated to the exploratory analytic phase; and the remaining 85% (n = 5965) reserved for confirmatory analyses. Psychometric evaluation included both exploratory and confirmatory factor analysis, reliability analysis, correlations, network analysis, and item response theory. Exploratory factor analysis indicated a three‐factor structure assessing daytime napping as to likelihood, consequences and effect on nighttime sleep. Confirmatory factor analysis largely confirmed this model with no sex invariance. The three‐factor structure showed adequate fit. The Biphasic Sleep Scale demonstrated good internal consistency (α = 0.88, Ω = 0.89). Network analysis revealed varying centrality and connectivity of items. Item response theory found items covering a range of biphasic sleep levels. Significant positive correlations with sleep criteria provided evidence for convergent validity. Further testing is warranted to confirm the factor structure, refine model parsimony, and establish clinical utility. With additional validation, it is hoped that the Biphasic Sleep Scale will become a widely utilized tool.
Do green finance and energy prices unlock environmental sustainability in Pakistan? Fresh evidence from RALS‐EG cointegration
Authors: Ali Mumtaz , Igunnu Peter Oluwasegun , Tursoy Turgut 
Published: December 2024

AbstractEven in the face of daunting challenges like climate change in Pakistan, every small step towards conservation and sustainability is a beacon of hope for a brighter, environmental quality. Thus, this study assesses the effect of green financing, economic growth, human capital, oil price, gas price and technological innovation on Pakistan's carbon dioxide emissions. The Residual Augmented Least Square‐Engle and Granger (RLAS‐EG) cointegration is performed to evaluate the effective long‐term association among variables and the Autoregressive Distributed Lag (ARDL) model to assess the coefficients. The results indicate that green finance, human capital and oil prices decrease carbon emissions in both the short and long term. Economic growth and increases in gas prices contribute to long‐term effects, whereas economic expansion decreases carbon emissions in the near term. The outcomes suggest endorsing policies that facilitate sustainable economic growth, enhance the uptake of environmentally friendly investments, foster technical advancements and bolster resilience against catastrophic events as measures to address climate change and mitigate CO2 emissions in Pakistan.
The E3 ubiquitin ligase TaGW2 facilitates TaSnRK1γ and TaVPS24 degradation to enhance stripe rust susceptibility in wheat
Authors: Li Shumin , Li Tian , Zhang Peiyin , Wang Xuemin , Feng Wenxuan , Zhang Yifang , Chen Bin , Liu Yuling , Zhan Gangming , Hao Chenyang , Zhang Xueyong , Kang Zhensheng , Mao Hude 
Published: December 2024

SummaryWheat stripe rust, caused by the fungal pathogen Puccinia striiformis f. sp. tritici (Pst), threatens global wheat production, and therefore discovering genes involved in stripe rust susceptibility is essential for balancing yield with disease resistance in sustainable breeding strategies. Although TaGW2 is well known to negatively regulate wheat kernel size and weight, its role in stress response remains unclear. Here, we found that TaGW2 transcription levels increased following inoculation with Pst or treatment with flg22 or chitin. TaGW2 knockdown lines showed enhanced resistance to multiple Pst races, while TaGW2 overexpression reduced host defence response, promoted Pst growth and development and increased wheat susceptibility to Pst. Additionally, TaGW2 could mediate the ubiquitination and degradation of both TaSnRK1γ and TaVPS24 via the 26S proteasome pathway. Silencing TaSnRK1γ or TaVPS24 in wheat increased sensitivity to Pst, whereas overexpressing either gene enhanced wheat defence response, indicating that TaSnRK1γ and TaVPS24 act as positive regulators of Pst resistance. This study reveals a previously unrecognized mechanism inhibiting plant immunity to Pst through TaGW2‐mediated ubiquitination and degradation of TaSnRK1γ and TaVPS24. This work also provides crucial genetic resources for breeding high‐yield, stripe rust‐resistant wheat varieties.
Early flowering enhances performance among conspecifics
Authors: Moreno‐Colom P. , Montesinos‐Navarro A. 
Published: December 2024

Abstract

Timing plays a crucial role in plant survival as it determines the environmental conditions during which each phenophase develops. In Mediterranean regions, with high temperatures and low precipitation during summer, the timing of flowering may impact plant performance. Different species avoid harsh abiotic conditions by flowering weeks or months earlier than others. On a shorter time scale, conspecifics that flower just a few days earlier may also gain biotic advantages, such as reduced competition for nutrients or pollinators.

We propose that earlier flowering, whether by days for conspecifics or by weeks to months for different species, allows plants to avoid biotic and abiotic stress, respectively, leading to increased reproductive success and growth. We hypothesize that: (i) earlier‐flowering species will have higher growth and reproductive success than other species co‐occurring in the community, and (ii) earlier‐flowering conspecifics will show higher growth and reproductive success than the average of their co‐occurring conspecifics. A field study was conducted in SE Spain using 98 co‐occurring individuals of four species. We monitored phenology, water loss, and growth over a growing season and estimated relative individual reproduction.

Early‐flowering species did not show higher relative reproduction than late, co‐occurring flowering species, although they differed in water loss. However, early‐flowering conspecifics had higher growth and relative reproduction than later‐flowering conspecifics, but did not differ in water loss.

Our results suggest that early flowering might reduce intraspecific competition among conspecifics, rather than enhance performance of those species that avoid harsh summer conditions (high temperatures and low precipitations).
Association of short‐term exposure to PM1 with hospital admission from total and cause‐specific respiratory diseases
Authors: Zhong Chenghui , Tian Qi , Wei Jing , Lu Wenfeng , Xu Ruijun , Lan Meiqi , Hu Nan , Qiu Lan , Zhang Han , Li SaiFeng , Shi Chunxiang , Liu Yuewei , Zhou Yun 
Published: December 2024

AbstractBackground and ObjectiveEvidence of short‐term exposure to particulate matter with an aerodynamic diameter ≤1 μm (PM1) on hospital admission for respiratory diseases (RDs) is limited. We aimed to estimate the associated risk of PM1 on hospital admissions for RDs.MethodsIn this time‐stratified case‐crossover study, we assigned cases who had been admitted to hospital for RDs in Guangdong, China between 2016 and 2019. Exposure to PM1 was assigned on the basis of the patient's residence for each case day and its control days. Conditional logistic regression models and distributed lag nonlinear models were used to quantify the association of PM1 exposure with hospital admission for RDs at lag 0–1 days.ResultsA total of 408, 658 hospital admissions for total RDs were recorded in the study period. Each 10 μg/m3 increase in PM1 was significantly associated with a 1.39% (95% confidence interval [CI]: 0.87%–1.91%), 1.97% (95% CI: 1.06%–2.87%) and 1.69% (95% CI: 0.67%–2.71%) increase in odds of hospital admissions for total RDs, chronic obstructive pulmonary disease (COPD) and pneumonia. The excess fraction of hospital admission for total RDs attributable to PM1 exposure was 6.03%, while 6.59% for COPD and 7.48% for pneumonia. Besides, higher excess fractions were more pronounced for hospital admission of total RDs in older patients (>75 years).ConclusionOur results support that PM1 is associated with increased risks of hospital admissions for RDs. It emphasizes the needs to pay attention to the effects of PM1 on respiratory health, especially among elderly patients.
White Migration—From the Context of Migration in East Asia
Authors: Debnár Miloš 
Published: December 2024

ABSTRACTThis article discusses recent development in the emerging field of white migration studies and particularly focuses on the studies on Western or white migrants in Japan and China in the past decade. It is outlining the main contribution of these studies to critical whiteness studies and migration studies as well as it identifies some of the lacunas in the research and possible theoretical and conceptual directions in which the research in this field can develop further. The article argues that establishing the transnational movement of white bodies as white migrations—what have been rather associated with privilege and different categories of mobility—contributes to contesting of the racialized categories of migration and understanding of the position of whiteness and role of white privilege in the context of global migration. The article suggests that by using common frameworks and concepts with the mainstream migration research and further analysis of the local contexts, the white migration research can contribute to our understanding of whiteness in the context of global migration without reinstating it as a Eurocentric category of research even more.