bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximate replication of Matsuda and Gobel (2004) for psychometric validation of the Foreign Language Reading Anxiety Scale
Authors: Hamada Akira , Takaki Shuichi 
Published: September 2019

AbstractThis paper reports an approximate replication of Matsuda and Gobel (2004) for the psychometric validation of the Foreign Language Reading Anxiety Scale (FLRAS). Their study examined the structural aspects of the FLRAS developed by Saito, Horwitz, and Garza (1999). The results showed that the FLRAS measured three different subcomponents of foreign language reading anxiety; none of the factors predicted foreign language performance in content-based and four-skill classes. The present study aimed to reconfirm the psychometric validity of the FLRAS because it has been widely employed to make foreign language reading anxiety researchable. Our study retained the same methodology, with the exception of the measurements of classroom performance and reading proficiency. Matsuda and Gobel's conclusions were reproduced by showing a weak relationship between classroom performance and foreign language reading anxiety measured by the three-factor model of the FLRAS. However, this study newly demonstrated a strong association of reading-anxiety subcomponents with learners' reading proficiency. The administration, scoring, and interpretation methods of the FLRAS were reconsidered based on the replicated results.
The Not So Targeted Instrument of Asset Freezes
Authors: Gordon Joy 
Published: September 2019

AbstractAsset freezes are sometimes viewed as the quintessential form of targeted sanctions—relatively effective in achieving their goals, while affecting only the individuals and companies that are “bad actors.” However, as part of the roundtable “Economic Sanctions and Their Consequences,” this essay argues that there are significant ethical problems raised by asset freezes and other forms of targeted financial sanctions. Sanctioners (specifically, the United Nations Security Council and the U.S. government) have long been criticized for targeting individuals and companies for arbitrary reasons or without adequate due process. However, there is a second concern that is less well known. Asset freezes and other targeted financial sanctions may be imposed on government officials, government agencies, or private companies that hold a critical role in the target country's economy. A country's central bank, national oil company, or national shipping line, for example, may be severely compromised as a result of its inclusion on a financial blacklist. In addition to the explicit prohibitions imposed by targeted financial sanctions, there is a chilling effect as well. This can be seen when international banks and corporations withdraw from the target country altogether because the burden of compliance with these measures is so great, and the potential penalties so high.
Unilateral Economic Sanctions, International Law, and Human Rights
Authors: Jazairy Idriss 
Published: September 2019

AbstractAs part of the roundtable “Economic Sanctions and Their Consequences,” this essay examines unilateral coercive measures. These types of sanctions are applied outside the scope of Chapter VII of the United Nations Charter, and were developed and refined in the West in the context of the Cold War. Yet the eventual collapse of the Berlin Wall did not herald the demise of unilateral sanctions; much to the contrary. While there are no incontrovertible data on the extent of these measures, one can safely say that they target in some way a full quarter of humanity. In addition to being a major attack on the principle of self-determination, unilateral measures not only adversely affect the rights to international trade and to navigation but also the basic human rights of innocent civilians. The current deterioration of the situation, with the mutation of embargoes into blockades and impositions on third parties, is a threat to peace that needs to be upgraded in strategic concern.
Battlefield Mercy: Unpacking the Nature and Significance of Supererogation in War
Authors: Renic Neil C. 
Published: September 2019

AbstractDebates over how best to ensure appropriate conduct in battle typically draw a binary distinction between rule compliance and rule violation. This framing is problematic, excluding a critical third element of battlefield conduct, supererogation—that is, positive acts that go beyond what is demanded by the explicit rules of war. This article investigates this moral category of action; specifically, situations in which combatants refrain from taking the life of an enemy despite their moral and legal license to do so. It first considers the moral tension between the duty of combatants to kill and battlefield mercy, and goes on to explore the factors that motivate the latter. The article then shifts to consider the significance of supererogation to the ongoing efforts to moderate the conduct of contemporary war. As the article illustrates, supererogatory restraint is constituted by values that when cultivated also incentivize adherence to the more explicit rules and standards of the battlefield. This is demonstrated through analysis of the conduct of Western special forces. The concept of supererogation is of further use when evaluating the origins and implications of “moral injury.” This is verified empirically in the context of armed unmanned aerial vehicles.
Opinions of general and adult congenital heart disease cardiologists on care for adults with congenital heart disease in Belgium: a qualitative study
Authors: Willems Ruben , de Hosson Michèle , De Backer Julie , Annemans Lieven 
Published: September 2019

AbstractBackground:The growing adult congenital heart disease (CHD) population requires efficient healthcare organisation. It has been suggested that clinically appropriate care be provided for individual patients on the least complex level possible, in order to alleviate saturation of special care programmes.Methods:Semi-structured interviews with 10 general and 10 adult CHD cardiologists were conducted to elucidate opinions on healthcare organisation in Belgium. A particular focus was placed on the potential role of general cardiologists. The software program NVivo 12 facilitated thematic analysis.Results:A discrepancy existed between how general cardiologists thought about congenital care and what adult CHD cardiologists considered the minimum knowledge required to adequately treat patients. Qualitative data were categorised under the following themes: knowledge dissemination, certification, (de)centralisation of care, the role of adult CHD cardiologists, the role of dedicated nurse specialists, and patient referral. It appeared to be pivotal to organise care in such a way that providing basic care locally does not impede the generation of sufficient patient volume, and to continue improving communications between different care levels when there is no referral back. Moreover, practical knowledge is best disseminated locally. Cardiologists’ opinions on certification and on the role of dedicated nurse specialists were mixed.Conclusion:On the basis of the results, we propose five recommendations for improving the provision of care to adults with CHD. A multidimensional approach to defining the role of different healthcare professionals, to improving communication channels, and to effectively sensitising healthcare professionals is needed to improve the organisation of care.
Winter and Summer Rossby Wave Sources in the CMIP5 Models
Authors: Nie Yu , Zhang Yang , Yang Xiu‐Qun , Ren Hong‐Li 
Published: September 2019

AbstractThe Rossby wave source (RWS) in the upper troposphere plays an important role in the tropical‐extratropical teleconnections. Using the daily outputs from the Phase 5 of the Coupled Model Intercomparison Project (CMIP5) models, the overall model performances in simulating the climatological Rossby wave sources in both winter and summer are evaluated. The ensemble mean of the CMIP5 models can simulate the large‐scale geographical distributions of the RWS reasonably close to the observations, with the simulations of RWS in general better in the Southern Hemisphere. For the Northern Hemisphere, most models overestimate the subtropical RWS but underestimate the midlatitude RWS in both winter and summer. Many models even fail to simulate the seasonal source‐sink shift of RWS in East Asia. Greatest intermodel differences are shown in East Asia, western North America in both seasons, and in the subtropical belt in winter hemisphere. Possible reasons for the model biases in RWS are further investigated. In the Northern Hemisphere, our analysis shows that model performance in simulating the local divergence, which might relate to the overly smoothed topography in Asia and western North America in the model, is most responsible for the biases of the RWS simulations. In the Southern Hemisphere, the bias in subtropical divergence pattern and tropical convection all contribute to the intermodel divergence of RWS simulation.
Verification and Improvement of the Capability of ENSEMBLES to Predict the Winter Arctic Oscillation
Authors: Zhang Dapeng , Huang Yanyan , Sun Bo 
Published: September 2019

AbstractThe winter Arctic Oscillation (AO) is important for understanding the Northern Hemisphere climate variability and predictability. However, ENSEMBLES models produce inconsistent predictions when applied to the interannual variability of the 1962–2006 winter AO. In this study, the interannual increment of the winter AO index (DY_AOI) during 1962–2006 is first improved by a dynamical‐statistical model with two predictors: the preceding autumn Arctic sea ice and the concurrent winter ENSEMBLES‐predicted sea surface temperature over the North Pacific. Next, the improved final AOI is obtained by adding the improved DY_AOI to the preceding observed AOI. Because the interannual increment approach can amplify prediction signals and takes advantage from the previous observed AOI, this method shows promise for significantly improving the interannual variability prediction capabilities of the winter AO during 1962–2006 in the ENSEMBLES models. Therefore, this study offers important insights for AO predictions, even other climate variables predictions.
Curie Depth, Heat Flux, and Thermal Subsidence Reveal the Pacific Mantle Outflow Through the Scotia Sea
Authors: Martos Yasmina M. , Catalán Manuel , Galindo‐Zaldívar Jesús 
Published: September 2019

AbstractThe sinking of the ocean sea bottom is produced by thermal cooling of the lithosphere. This evolution is determined by the underlying asthenospheric mantle. Estimation of the Curie Depth variations in the Scotia Sea by using a spectral approach and applied on magnetic anomaly data led us to determine a thermal model and derive a heat flux map. Using multichannel seismic and bathymetry data, we show that the West Scotia Sea reaches thermal equilibrium more quickly than other oceans do and thermally behaves like old oceanic crust in large oceans, following a different empirical age (t, in Ma)‐depth (d, in m) relationship, d(t) = 4,480 − 19,380 exp(−t/4). For oceanic crusts of the same age, underlain by different shallow mantle controlling the heat supply, low heat flux values imply older ages than those predicted for large oceans based on the empirical relationships of the standard plate model. These circumstances, together with the new heat flux map, shed light on the anomalous evolution of the Scotia Sea, a consequence of the present Pacific mantle outflow through the Drake Passage. Two branches of elevated heat flux surround the Shackleton Fracture Zone and extend to the northern and southern boundaries of the Scotia Plate. Most of the heat sources are located in the flanks, whereas the colder parts are centrally located. This signature supports the Drake Passage's role as a main mantle gateway for Pacific outflow toward the Atlantic reservoir favoring the oceanic spreading activity of this ocean.
Surface Height and Sea Ice Freeboard of the Arctic Ocean From ICESat‐2: Characteristics and Early Results
Authors: Kwok R. , Markus T. , Kurtz N. T. , Petty A. A. , Neumann T. A. , Farrell S. L. , Cunningham G. F. , Hancock D. W. , Ivanoff A. , Wimert J. T. 
Published: September 2019

AbstractWe present the first winter season of surface height and sea ice freeboards of the Arctic Ocean from the new Ice, Cloud, and Land Elevation Satellite (ICESat‐2; IS‐2) mission. The Advanced Topographic Laser Altimeter System onboard has six photon‐counting beams for surface profiling with a 10‐kHz pulse rate (interpulse distance ~0.7 m) and footprints of ~17 m. Geolocated heights assigned to individual photons scattered from the surface allow significant flexibility in the construction of height distributions used in surface finding. For IS‐2 sea ice products, a fixed 150‐photon aggregate is used to control height precision and obtain better along‐track resolution over high reflectance surfaces. Quasi‐specular returns in openings as narrow as ~27 m, crucial for freeboard calculations, are resolved. The fixed photon aggregate results in unique variable along‐track resolutions and nonuniform sampling (17 m × 27 m to 17 m × 200 m for the strong beams) of the surface. The six profiling beams—three pairs separated by 3.3 km with a strong and weak beam in each pair—provide correlated statistics at regional length scales for assessment of beam‐to‐beam retrieval consistency and accuracy. Analysis shows along‐track height precisions of ~2 cm and agreement in the monthly freeboard distributions across the strong beams to 1–2 cm. In this paper, we describe briefly the approaches used in surface height and freeboard retrievals from Advanced Topographic Laser Altimeter System photon clouds and detail the key features of these along‐track sea ice products, focusing on the first release of data collected over the Arctic Ocean, which spans the period between 14 October 2018—the start of data collection—and the end of March 2019.
Unraveling Multiple Thermotectonic Events Accommodated by Crustal‐Scale Faults in Northern Iberia, Spain: Insights From K‐Ar Dating of Clay Gouges
Authors: Aldega L. , Viola G. , Casas‐Sainz A. , Marcén M. , Román‐Berdiel T. , van der Lelij R. 
Published: September 2019

AbstractLarge‐scale faults in the continental crust are significant features that control the evolution of sedimentary basins and intraplate mountain chains. Deciphering their evolution is a significant task because faults slip and reactivate in a variety of geological settings. In this work, clay gouges of two major orogen‐scale, long‐lived faults in northern Iberia, the Río Grío and Vallès‐Penedès Faults, were investigated by X‐ray diffraction and K‐Ar isotopic analysis. Illite polytype determinations of 44 subfractions (from <0.1 to 10 μm) allowed us to discriminate between authigenic/synkinematic illite crystals formed during faulting and detrital illite crystals inherited from the host rock. K‐Ar dating provided a detailed set of ages corresponding to key stages of the thermotectonic evolution of the Iberian Plate: (a) the Permian to Late Triassic extensional/transtensional activity associated to the emplacement of Late Variscan magmatic bodies and hydrothermal mineralizations, (b) the opening of the Central Atlantic Rift during Late Triassic‐Early Jurassic times, (c) the Late Jurassic‐Early Cretaceous rifting that led to the development of Mesozoic extensional/transtensional basins in northern Iberia, (d) the final stage of the anticlockwise rotation of the Iberian Plate with respect to Eurasia and the accommodation of the first Pyrenean compressional pulses in Campanian time, and (e) the positive inversion of Mesozoic extensional basins due to far‐field stresses associated with the Alpine orogeny during the Paleogene. The results highlight that thermotectonic conditions characterized by high‐geothermal gradients strongly favor fault movement and neoformation of clay minerals in fault gouges, regardless of the prevailing tectonic regime.
Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer
Authors: Yang Ying , Li Ziming , Yuan Hong , Ji Wenxiang , Wang Kaixuan , Lu Tingting , Yu Yongfeng , Zeng Qingyu , Li Fan , Xia Weiliang , Lu Shun 
Published: September 2019

AbstractMicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, and metastasis. However, the regulatory mechanism between miRNAs and FGFR1 in lung cancer remains unclear and extremely critical. miR-214-3p was sharply decreased and showed a significantly negative correlation with FGFR1 in lung cancer patients (n = 30). Luciferase reporter assay confirmed that miR-214-3p could downregulate FGFR1 by directly targeting 3′-untranslated region (UTR). miR-214-3p inhibited the processes of epithelial–mesenchymal transition and Wnt/MAPK/AKT (Wnt/mitogen-activated protein kinase/AKT) signaling pathway by targeting FGFR1. Moreover, miR-214-3p not only established a negative feedback regulation loop with FGFR1 through ERK (extracellular signal-regulated kinase) but also developed a synergism with FGFR1 inhibitor AZD4547. In conclusion, our study demonstrated the regulatory mechanism between miR-214-3p and FGFR1 in lung cancer. miR-214-3p acts as a vital target in FGFR1-amplified lung cancer by forming a miR-214-3p-FGFR1-Wnt/MAPK/AKT signaling pathway network. Co-targeting miR-214-3p and FGFR1 could provide greater benefits to patients with FGFR1-amplified lung cancer.
Bimodal distribution of tone-matching deficits indicates discrete pathophysiological entities within the syndrome of schizophrenia
Authors: Dondé Clément , Martínez Antigona , Kantrowitz Joshua T. , Silipo Gail , Dias Elisa C. , Patel Gaurav H. , Sanchez-Peña Juan , Corcoran Cheryl M. , Medalia Alice , Saperstein Alice , Vail Blair , Javitt Daniel C. 
Published: September 2019

AbstractTo date, no measures are available that permit differentiation of discrete, clinically distinct subtypes of schizophrenia (SZ) with potential differential underlying pathophysiologies. Over recent years, there has been increasing recognition that SZ is heterogeneously associated with deficits in early auditory processing (EAP), as demonstrated using clinically applicable tasks such as tone-matching task (TMT). Here, we pooled TMT performances across 310 SZ individuals and 219 healthy controls (HC), along with clinical, cognitive, and resting-state functional-connectivity MRI (rsFC-MRI) measures. In addition, TMT was measured in a group of 24 patients at symptomatic clinical high risk (CHR) for SZ and 24 age-matched HC (age range 7–27 years). We provide the first demonstration that the EAP deficits are bimodally distributed across SZ subjects (P < 0.0001 vs. unimodal distribution), with one group showing entirely unimpaired TMT performance (SZ-EAP+), and a second showing an extremely large TMT impairment (SZ-EAP−), relative to both controls (d = 2.1) and SZ-EAP+ patients (d = 3.4). The SZ-EAP− group predominated among samples drawn from inpatient sites, showed higher levels of cognitive symptoms (PANSS), worse social cognition and a differential deficit in neurocognition (MATRICS battery), and reduced functional capacity. rsFC-MRI analyses showed significant reduction in SZ-EAP− relative to controls between subcortical and cortical auditory regions. As opposed to SZ, CHR patients showed intact EAP function. In HC age-matched to CHR, EAP ability was shown to increase across the age range of vulnerability preceding SZ onset. These results indicate that EAP measure segregates between discrete SZ subgroups. As TMT can be readily implemented within routine clinical settings, its use may be critical to account for the heterogeneity of clinical outcomes currently observed across SZ patients, as well as for pre-clinical detection and efficacious treatment selection.
SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
Authors: Miao Qi , Hill Matthew C. , Chen Fengju , Mo Qianxing , Ku Amy T. , Ramos Carlos , Sock Elisabeth , Lefebvre Véronique , Nguyen Hoang 
Published: September 2019

AbstractTissue injury induces changes in cellular identity, but the underlying molecular mechanisms remain obscure. Here, we show that upon damage in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state, altering particularly the cytoskeletal/extracellular matrix (ECM) components and differentiation program. We show that SOX11 and its closest relative SOX4 dictate embryonic epidermal state, regulating genes involved in epidermal development as well as cytoskeletal/ECM organization. Correspondingly, postnatal induction of SOX11 represses epidermal terminal differentiation while deficiency of Sox11 and Sox4 accelerates differentiation and dramatically impairs cell motility and re-epithelialization. Amongst the embryonic genes reactivated at the wound edge, we identify fascin actin-bundling protein 1 (FSCN1) as a critical direct target of SOX11 and SOX4 regulating cell migration. Our study identifies the reactivated embryonic gene program during wound repair and demonstrates that SOX11 and SOX4 play a central role in this process.
Miocene restriction of the Pacific-North Atlantic throughflow strengthened Atlantic overturning circulation
Authors: Kirillova Valeriia , Osborne Anne H. , Störling Tjördis , Frank Martin 
Published: September 2019

AbstractExport of warm and salty waters from the Caribbean to the North Atlantic is an essential component of the Atlantic Meridional Overturning Circulation (AMOC). However, there was also an active AMOC during the Miocene, despite evidence for an open Central American Seaway (CAS) that would have allowed low-salinity Pacific waters to enter the Caribbean. To address this apparent contradiction and to constrain the timing of CAS closure we present the first continuous Nd isotope record of intermediate waters in the Florida Strait over the past 12.5 million years. Our results indicate that there was no direct intermediate water mass export from the Caribbean to the Florida Strait between 11.5 and 9.5 Ma, at the same time as a strengthened AMOC. After 9 Ma a strong AMOC was maintained due to a major step in CAS closure and the consequent cessation of low-salinity Pacific waters entering the Caribbean.
Pupil-linked phasic arousal evoked by violation but not emergence of regularity within rapid sound sequences
Authors: Zhao Sijia , Chait Maria , Dick Fred , Dayan Peter , Furukawa Shigeto , Liao Hsin-I 
Published: September 2019

AbstractThe ability to track the statistics of our surroundings is a key computational challenge. A prominent theory proposes that the brain monitors for unexpected uncertainty – events which deviate substantially from model predictions, indicating model failure. Norepinephrine is thought to play a key role in this process by serving as an interrupt signal, initiating model-resetting. However, evidence is from paradigms where participants actively monitored stimulus statistics. To determine whether Norepinephrine routinely reports the statistical structure of our surroundings, even when not behaviourally relevant, we used rapid tone-pip sequences that contained salient pattern-changes associated with abrupt structural violations vs. emergence of regular structure. Phasic pupil dilations (PDR) were monitored to assess Norepinephrine. We reveal a remarkable specificity: When not behaviourally relevant, only abrupt structural violations evoke a PDR. The results demonstrate that Norepinephrine tracks unexpected uncertainty on rapid time scales relevant to sensory signals.