bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFORMED CONSENT DALAM PELAYANAN KESEHATAN DI RUMAH SAKIT (ANALISIS PUTUSAN KASASI MAHKAMAH AGUNG NOMOR 3004 K/PDT/2014)
Authors: Doni  , Yeti Kurniati  , Thariq Muslim  , Dhea Alfie  , Ery Firsanti  , Hodijatussolihah  
Published: February 2025

“Informed consent in healthcare services at hospitals is a crucial aspect that must be understood and implemented by medical professionals. The Supreme Court Decision Number 3004 K/Pdt/2014 highlights the importance of informed consent prior to medical actions being taken. This analysis employs a normative legal research method to evaluate the application of informed consent based on existing regulations. Informed consent requires doctors to provide clear information regarding the diagnosis, purpose of the action, risks, and available alternatives. This aims to enable patients to make conscious and informed decisions. In the ruling, the judge emphasized that merely obtaining a patient's signature on a document is insufficient; adequate explanations must be provided so that patients fully understand the consequences of medical actions. This decision also underscores the legal responsibilities of medical professionals and hospitals in cases of negligence in providing information. In emergency situations, doctors may act based on presumed consent but must still provide information once the emergency is resolved. Thus, the application of the informed consent principle not only protects patient rights but also provides legal protection for doctors, fostering transparency in the relationship between patients and healthcare providers”.

Keywords: Informed consent; Healthcare services; Hospital; Patient rights; Supreme Court Decision Number 3004 K/Pdt/2014
ПІДГОТОВКА НОВОГО ВЧИТЕЛЯ ДЛЯ ОБ'ЄДНАНОЇ ЄВРОПИ: ІННОВАЦІЙНІ ФОРМИ ПЕДАГОГІЧНОЇ ОСВІТИ
Authors: Дінжос Роман , Манькусь Ірина , Недбаєвська Людмила , Дармосюк Валентина 
Published: February 2025

Фундаментальна проблема, на вирішення якої спрямовано дослідження: дисбаланс між запитами українського суспільства на висококваліфікованих педагогічних працівників, перспективами його розвитку, глобальними технологічними змінами та існуючою системою освіти, а також готовністю педагогічних працівників до дизайну освітніх середовищ та реалізації освітніх реформ в Україні. Саме ця проблема сучасної системи освіти потребує розв’язання і визначена в Концепції сталого розвитку (2023 р.), Концепції розвитку педагогічної освіти (2018 р.), Концепції розвитку STEM-освіти в Україні (2020 р.) та Стандарті базової загальної середньої освіти (2020 р.). Одним з можливих шляхів розв’язання цієї проблеми є підготовка вчителя природничо –математичних дисциплін до дизайну освітнього середовища на основі технологій STEM-освіти. В статті запропоновано нестандартні форми педагогічної освіти, які спрямовані на формування та розвиток професійних компетентностей нового вчителя об’єднаної Європи.
Дослідження проведено на базі Чорноморського національного університету ім. Петра Могили в рамках роботи студентоцентрованого навчально-практичного центру при кафедрі фізики та математики. В процесі дослідження використовувалась наступні методи: педагогічний експеримент, абстрактно - логічний; графічний; методи аналізу та синтезу, аналогії, порівняння; математичне моделювання, педагогічне прогнозування.
Практичне значення дослідження полягає у створенні елементів інноваційної наукової інфраструктури на кафедрі фізики та математики з метою підготовки конкурентно спроможних фахівців для ринку освітніх послуг об’єднаної Європи.
Модернізація підготовки майбутнього вчителя природничо – математичних дисциплін здійснювалася кафедрою шляхом введення нових навчальних курсів для майбутніх вчителів фізики та математики, а також через активне залучення їх до реалізації освітніх проектів STEM-центру створеного при кафедрі.
Результати виконання наукового дослідження представлені викладачами кафедри у навчальних посібниках «Фізичний експеримент в контексті STEM освіти :перший концентр навчання», «Фізичний експеримент в контексті STEM освіти: другий концентр навчання», «Комбінаторика: практикум з розв’язування задач», «Методика викладання математики: показникова та логарифмічна функції», «Дизайн освітнього середовища», «STEM-освіта- трансдисциплінарний підхід».
Запровадження університетських студій як нестандартної форми педагогічної освіти дає можливість забезпечити максимальне наближення психолого-педагогічної та методичної підготовки здобувачів до умов практичної фахової діяльності, а також розвивати їх креативні якості, шляхом формування здібностей: будувати умозаключення у вигляді гіпотез, встановлювати причинно – наслідкові зв’язки, завдяки яким стає можливим з’ясування ланцюга «минуле – сучасне - майбутнє», передбачати свій педагогічний вплив на діяльність здобувачів освіти, планувати і проводити експеримент.
Unveiling the Productivity Paradox: Remote Work and Employee Performance in the IT Sector Through the Lens of Work Stress
Authors: Bhandari Aastha , Bhattarai Ujjwal , Timsina Sujal Mani 
Published: February 2025

Purpose: The purpose of the study is to examine the influence of individual work-related factors (i.e., workload, work-life balance, job satisfaction, and social support) on productivity among young IT professionals working remotely through the mediating effect of work stress.
Design/methodology/approach: This study employed a cross-sectional design and adopted a quantitative approach to analyse the data gathered from 271 respondents, selected through purposive sampling. Both direct and indirect structural relationship was analysed through Smart PLS 4.0.
Findings: The results indicated that workload, work-life balance, and job satisfaction were significant predictors of employee performance, with work stress also having a mediating effect on these variables. The findings strongly support SET, EDT, JD-R, and work-family border theory.
Conclusion: Productivity is sustained through task completion and balanced and satisfying work experiences that accommodate personal and professional needs. The study also exhibits the importance of mitigating stress management in contemporary work management and meeting the needs of the younger generation, which can lead to enhanced engagement.
Practical Implications: In order to meet the needs of the younger generation, organisations must create flexible work policies that incorporate hybrid work models, support employees' well-being by implementing stress management initiatives, and create comprehensive guidelines to handle issues like burnout, distractions, social connectivity, and team engagement in remote settings.
Originality/Value: By integrating the perspectives from HRM and organisational psychology, this study provides a holistic model and addresses a critical gap in the literature, particularly in remote work practices, specifically for young employees in the IT sector.
Keywords: Employee productivity, IT sector, remote work, young cohorts
Paper Type: Research Paper
JEL Classification: J24, J28, J86, M54
Molecular Analysis of Chloroquine and Sulfadoxine/Pyrimethamine Resistant Markers in Plasmodium Falciparum Isolated from Three Provinces in Southern Thailand
Authors: Thodsapol Autchariya , Sawangjaroen Nongyao , Chemoh Waenurama , Mungthin Mathirut , Buncherd Hansuk , Thanapongpichat Supinya 
Published: February 2025

Objective: This study investigated mutations in various genes associated with chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) resistance in P. falciparum; including the P. falciparum chloroquine resistance transporter (pfcrt), P. falciparum multidrug resistance 1 (pfmdr1), P. falciparum dihydrofolate reductase (pfdhfr), and P. falciparum dihydropteroate synthase (pfdhps).Material and Methods: A total of 104 P. falciparum samples were obtained from patients across three (Ranong, Surat Thani and Yala) provinces of southern Thailand; between 2012 and 2019. To assess the genetic polymorphisms, pfcrt K76T and pfmdr1 N86Y were identified using PCR-RFLP assay, and pfdhfr C59R and pfdhps K540E was identified using Semi-nested PCR and nucleotide sequencing.Results: Genetic analysis revealed that 61 (58.65%) isolates were positive for pfcrt and 55 (52.88%) for pfmdr1. Notably, the Ranong province isolates showed high prevalence of pfdhfr 51I, 59R, 108N, and 164L mutations (IRN-L) along with pfdhps 540E mutation. The Surat Thani province isolates exhibited the highest frequency of quadruple mutations in both pfdhfr and pfdhps genes. Conclusion: The surveillance guidelines and policy formulation of appropriate Malaria treatment strategies must be implemented in these locations.
МАЛЫЙ БИЗНЕС КАК ФАКТОР РАЗВИТИЯ РЕГИОНАЛЬНОЙ ЭКОНОМИКИ (НА ПРИМЕРЕ ВОСТОЧНО-КАЗАХСТАНСКОЙ ОБЛАСТИ КАЗАХСТАНА)
Authors: Ауезова К.Т. , Шаметова А.А. , Елемесов А.К. 
Published: February 2025

Актуальность предлагаемой темы научной статьи связана с привлекательностью для развития такой формы функционирования субъекта рынка в условиях глобального экономического кризиса, как малый бизнес и его влияние на рост экономики регионов Казахстана.
Целью исследования является изучение динамики развития малого бизнеса и оценка его реальной роли в развитии экономики региона. Малый бизнес в условиях цифровой экономики определил свою деловую активность, несмотря на введенные ограничения связанные с пандемией COVID-19, поскольку в нем задействована основная часть населения, реализующая свои бизнес идеи и приоритеты в части развития собственных предпринимательских инициатив и собственности для получения сопоставимого предпринимательского дохода. Для поддержания реализации малыми субъектами своих предпринимательских инициатив, а также обеспечения высокой занятости населения необходимо институту государства рассматривать развитие малого бизнеса с учетом специфики экономики регионов, позволяющие дать возможность повышение его производственного потенциала в контексте интеграции с субъектами крупного бизнеса. Рассмотрены основные факторы экономики Восточного Казахстана региона, что позволять субъектам малого бизнеса оценить свои возможности и перспективы развития в конкурентной среде. Следовательно, выявлено, что малый бизнес напрямую обеспечивает рост Валового регионального продукта.
Genomic Testing of Clark's Theory of the British Industrial Revolution: A Note on Statistical Accuracy and Power
Authors: Connor Gregory 
Published: February 2025

Clark[1][2] hypothesizes that the British Industrial Revolution was partly caused by a gradual evolution in the frequency distribution of genetic variants associated with intelligence and related phenotypes within the British population. Clark's theory can be tested rigorously by examining the time-series trend of average polygenic index scores on intelligence-related phenotypes, using genotyped DNA from human skeletal remains. This note discusses various time-series statistical methods for such a study and uses Monte Carlo simulation to evaluate statistical power and estimation accuracy for feasible sample sizes.
Гейміфікація при вивченні небесної механіки за допомогою Kerbal Space Program
Authors: Ponomarenko Pavlo 
Published: February 2025

The rapid development of technologies and their implementation in the educational process provide an opportunity to apply gamification, that is, the use of game mechanics and elements for in-depth study of a complex technical discipline. Computer games such as Kerbal Space Program (KSP) have already created an environment where students can comprehend and practically apply the theory of space mechanics with a sense of challenge and reward. The use of gamification in the learning process has many advantages: improving academic performance, developing interaction between students, and increasing interest in technical sciences. The subject of this study is the capabilities and processes of the KSP game. The object of this research is the process and means of gamification in the study of celestial mechanics. The aim of this work is to study the possibilities, limitations, and prospects of using Kerbal Space Program in the gamification of the study of the basic concepts of celestial mechanics. The implementation of the stated research goal involves solving the following tasks: analyzing the ability of KSP to implement certain celestial mechanics; studying the prospects of KSP in teaching the basic concepts of celestial mechanics through game mechanics; study of the correspondence of the game physical model to real physical processes; and identification of limitations and prospects for the use of gamification through KSP for educational purposes. This study used the system analysis method of computer gamification tools. The following results were obtained in the course of the study: during the comprehensive analysis of KSP, it was established that the game complies with the basic laws of celestial mechanics and is capable of fairly accurately modeling orbital motion, maneuvers, gravitational phenomena, etc.; the main limitations and prospects for the use of KSP in the educational process were outlined. Conclusions: the study demonstrates that KSP implements the basic principles of celestial mechanics and provides tools for the practical mastery of complex concepts by students. This study shows the significant potential of the game, which allows significantly expanding educational opportunities in the study of celestial mechanics, and the interactive format of the game allows students to learn complex physical phenomena and concepts in an accessible and visual way.
Terapi Foot Massage untuk Menurunkan dan Menstabilkan Tekanan Darah pada Penderita Hipertensi Gestasional
Authors: Herdiana Yana , Galaupa Resi , SR Nurqalbi 
Published: February 2025

Hipertensi atau tekanan darah tinggi merupakan suatu kondisi dengan tekanan darah yang meningkat secara terus menerus pada pembuluh darah. Hipertensi di definisikan sebagai tekanan darah sistolik kurang lebih 140 mmHg serta tekanan darah diastolik kurang lebih 90 mmHg. pijat kaki merupakan alternatif terbaik untuk mengurangi tingkat tekanan darah diantara penderita hipertensi. Pijat memiliki efek meningkatkan sirkulasi, mengeluarkan produk sisa dari tubuh, meningkatkan mobilitas sendi, mengurangi rasa sakit dan menguragi ketegangan otot. Tujuan penelitian ini untuk Mengetahui terapi foot massage untuk menurunkan dan menstabilkan tekanan darah pada penderita hipertensi gestasional di Puskesmas Saketi Tahun 2023. Metode yang digunakan yaitu penelitian quasi experimental dengan pendekatan one group pre post design. Penelitian ini memberikan pretest kepada responden sebelum dilakukan foot massage dan post test sesudah melakukan foot massage. Analisis data menggunakan Wicoxon Signed Rank Test. Populasi dalam penelitian ini adalah ibu hamil penderita hipertensi yaitu 30 orang. Hasil penelitian menunjukkan terdapat pengaruh Terapi Foot Massage untuk menurunkan dan menstabilkan tekanan darah (nilai p = 0,000) pada penderita hipertensi gestasional di Puskesmas Saketi Tahun 2023.
Analisis Pengelolaan Limbah Medis Puskesmas di Kota Banda Aceh
Authors: Sufiani Dessi , Ramadhani Nur Rizky , Lukman Lukman 
Published: February 2025

Pusat kesehatan masyarakat (Puskesmas) menghasilkan volume limbah medis Bahan Berbahaya Beracun (B3) yang besar dan merata diseluruh Indonesia. Menurut data dari Kemenkes RI tahun 2020 Puskesmas yang melakukan pengelolaan limbah medis sesuai dengan standar. Penelitian ini bertujuan untuk menganalisis pengelolaan limbah medis puskesmas di Kota Banda Aceh. Penelitian ini menggunakan metode penelitian kualitatif dengan rancangan studi kasus serta pengumpulan data dengan teknik wawancara, observasi dan telaah dokumen. Informan kunci dalam penelitian ini berjumlah 17 orang yaitu Kepala Bidang Kesehatan Masyarakat Dinas Kesehatan Kota Banda Aceh (1 orang), Kepala Seksi Penyehatan Lingkungan (1 orang), Kepala puskesmas (5 orang), informan pendukung tenaga sanitarian (5 Orang), dan tenaga pelaksana pengelola limbah medis di puskesmas (5 orang). yang ditentukan melalui tekhnik purpose sampling. temuan emperis diketahui bahwa puskesmas diKota Banda Aceh telah melakukan pengelolaan sampah limbah padat mulai dari pemilahan, pengumpulan, penyimpanan dan pengangkutan, dalam pengelolaan limbah medis cair sudah menggunakan IPAL (Instalasi pengelolaan Air Limbah) yang disalurkan melalui wastafel khusus pada tiap ruangan, masih tidak sesuai dengan Peraturan Menteri Lingkungan Hidup RI No. 68 Tahun 2016 karena membuang limbah medis cair langsung sedangkan pada limbah padat medis pada tahap pengelolaan dan pemusnahan masih tidak sesuai dengan Permenkes RI Nomor 18 Tahun 2020 yaitu penyimpanan sementara lebih dari 2 hari namun tidak menggunakan cold storage. Kesimpulan : Dinas Kesehatan diharapkan dapat merencanakan pengadaan Cold Storage, Rehabilitasi tempat penyimpanan sementara, rehabilitasi saluran IPAL dan peningkatan SDM pelaksana ( cleaning service) dengan OJT (on the job training ) yang disertai dengan sertifikat pelatihan.
Batch-fabricated full glassy carbon fibers for real-time tonic and phasic dopamine detection
Authors: Siwakoti Umisha , Pwint May Yoon , Broussard Austin M. , Rivera Daniel R. , Cui X. Tracy , Castagnola Elisa 
Published: February 2025

Dopamine (DA) is a critical neurotransmitter that is key in regulating motor functions, motivation, and reward-related behavior. Measuring both tonic (baseline, steady-state) and phasic (rapid, burst-like) DA release is essential for elucidating the mechanisms underlying neurological disorders, such as schizophrenia and Parkinson’s disease, which are associated with dysregulated tonic and phasic DA signaling. Carbon fiber microelectrodes (CFEs) are considered the gold standard for measuring rapid neurotransmitter changes due to their small size (5–10 µm), biocompatibility, flexibility, and excellent electrochemical properties. However, achieving consistent results and large-scale production of CFE arrays through manual fabrication poses significant challenges. We previously developed flexible glassy carbon (GC) microelectrode arrays (MEAs) and GC fiber-like MEAs (GCF MEAs) for neurotransmitter detection and electrophysiology recording. We also demonstrated the feasibility of fabricating GC MEA with both GC electrodes and interconnects made from a single homogeneous material, eliminating the need for metal interconnections and addressing related concerns about electrical and mechanical stability under prolonged electrochemical cycling. Building on our prior experience, we now present a double-etching microfabrication technique for the batch production of 10 μm × 10 µm full GC fibers (fGCFs) and fGCF arrays, composed entirely of homogeneous GC material. This process uses a 2 µm-thick low-stress silicon nitride as the bottom insulator layer for the fGCFs. The effectiveness of the fabrication process was validated through scanning electron microscophy (SEM) and energy dispersive X-ray spectroscopy (EDS) elemental analyses, which confirmed the uniformity of the Si₃N₄ insulation layer and ensured the overall integrity of the fGCFs. Using finite element analysis, we optimized the fGCF form factor to achieve self-penetration up to 3 mm into the mouse striatum without additional support. The electrochemical characterization of fGCFs demonstrated high electrical conductivity and a wide electrochemical window. The ability of fGCFs to detect phasic and tonic DA release was confirmed using fast scan cyclic voltammetry (FSCV) and square wave voltammetry (SWV), respectively, both in vitro and in vivo. With their high sensitivity for phasic and tonic DA detection, combined with a scalable fabrication process and self-supporting insertion capability, fGCFs are promising sensors that offer enhanced practicality for comprehensive DA monitoring.
Mathematical modeling of a MoSe₂-based SPR biosensor for detecting SARS-CoV-2 at nM concentrations
Authors: Tene Talia , Bonilla García Nataly , Marcatoma Tixi Jessica Alexandra , Dávalos Villegas Martha Ximena , Vacacela Gomez Cristian , Bellucci Stefano 
Published: February 2025

The rapid and accurate detection of SARS-CoV-2 remains a critical challenge in biosensing technology, necessitating the development of highly sensitive and selective platforms. In this study, we present a mathematical modeling approach to optimize a MoSe₂-based Surface Plasmon Resonance (SPR) biosensor for detecting the novel coronavirus at nM scale. Using the Transfer Matrix Method (TMM), we systematically optimize the biosensor’s structural parameters, including silver (Ag), silicon nitride (Si₃N₄), molybdenum diselenide (MoSe₂), and thiol-tethered single-stranded DNA (ssDNA) layers, to enhance sensitivity, detection accuracy, and optical performance. The results indicate that an optimized 45 nm Ag layer, 10 nm Si₃N₄ layer, and monolayer MoSe₂ configuration achieves a resonance shift (Δθ) of 0.3° at 100 nM, with a sensitivity of 197.70°/RIU and a detection accuracy of 5.24 × 10⁻2. Additionally, the incorporation of a 10 nm ssDNA functionalization layer significantly enhances molecular recognition, lowering the limit of detection (LoD) to 2.53 × 10⁻5 and improving overall biosensing efficiency. Sys₅ (MoSe₂ + ssDNA) outperforms Sys₄ (MoSe₂ without ssDNA) in terms of specificity and reliability, making it more suitable for practical applications. These findings establish the MoSe₂-based SPR biosensor as a highly promising candidate for SARS-CoV-2 detection, offering a balance between high sensitivity, optical stability, and molecular selectivity, crucial for effective viral diagnostics.
Overview of distinct 8-oxoguanine profiles of messenger RNA in normal and senescent cancer cells
Authors: Huang Jingwen , Lin Yu , Zhao Yingying , Wei Lingbo 
Published: February 2025

BackgroundCellular senescence plays a key role in the development of cancer, but the underlying mechanisms are unknown. Recently, several recent studies have shown that RNA methylation is closely related to cancer cell aging. 8-Oxoguanine (o8G) is an important and widely distributed methylation modification whose role in cancer cell senescence is far from elucidated.MethodsIn this study, senescent cancer cell models (CaCO2 cells) were constructed by knocking down the ADAR1 gene. RNA immunoprecipitation sequencing was used to identify the o8G peaks on messenger RNA (mRNA) of normal CaCO2 cells and senescent CaCO2 cells, and the distribution characteristics of mRNA o8G modification were identified. Further bioinformatics analysis of the sequencing data was performed to preliminarily elucidate the potential function of the o8G-modified mRNA.ResultsThere were significant differences in mRNA o8G modification distribution between normal and senescent CaCO2 cells. It is suggested that o8G modification may play a key role in inducing cancer cells or promoting cancer cell senescence. Gene ontology (GO) enrichment analysis showed that the mRNAs modified by o8G were enriched in Cellular component organization or biogenesis, Focal adhesion, and RNA binding. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the genes modified by o8G are concentrated in Focal adhesion signaling pathway, Small cell lung cancer signaling pathway and Proteoglycans in cancer signaling pathway.ConclusionThis study preliminarily revealed the different distribution patterns of o8G modification between normal CaCO2 cells and senescent CaCO2 cells. Our study established the link between o8G modification and cancer cell senescence, which provides a new insight into the mechanism of cancer cell senescence and a potential therapeutic target for subsequent cancer treatment.