bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global epidemiology of serogroup Y invasive meningococcal disease: a literature review
Authors: Tin Tin Htar Myint , Findlow Jamie , Balmer Paul , Swerdlow David 
Published: December 2024

Abstract
Serogroup epidemiology of invasive meningococcal disease (IMD) is constantly evolving, varying by time and location. Surveillance reports have indicated a rise in meningococcal serogroup Y (MenY) in some regions in recent years. This systematic literature review explores the evolving epidemiology of MenY IMD globally based on review of recent articles and national surveillance reports published between 1 January 2010 and 25 March 2021. Generally, MenY incidence was low (<0.2/100,000) across all ages in most countries. The reported incidence was more frequent among infants, adolescents, and those aged ≥65 years. More than 10% of all IMD cases were MenY in some locations and time periods. Implementation of vaccination evolved over time as the rise in MenY IMD percentage occurred. Cases decreased in countries with quadrivalent vaccine programs (e.g., United Kingdom, the Netherlands, United States, and Australia), whereas the MenY burden increased and made up a large proportion of cases in areas without vaccine programs. Continuous monitoring of epidemiologic changes of IMD is essential to establish MenY burden and for implementation of prevention strategies.
Identification of novel sources of bacterial leaf blight resistance in wild species of rice
Authors: Tannidi Bhagyasri , V. G Ishwarya Lakshmi , M.S Anantha , G. S. Laha , R. M. Sundaram , P. Senguttuvel , Chandavarapu Raveendra , Dasari Aleena , Ghazi Irfan Ahmad , V Padma , Vamireddy Lakshmi Narayana Reddy , Channappa Gireesh 
Published: December 2024

Abstract
Wild species of rice possess tremendous genetic variations and harbour resistance genes for biotic stresses. Bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is a major disease affecting rice production globally. The current study characterized 116 accessions from 17 species of Oryza for BB disease during three seasons viz., kharif 2020, rabi 2020–21, kharif 2021 using an isolate of Xanthomonas oryzae pv. oryzae (Xoo) strain IX-020. A total of 40 accessions including Oryza rufipogon, O. nivara, O. officinalis and O. australiensis showed consistence resistance to the bacterial blight disease across the seasons. These accessions were further subjected to molecular characterization using 11 Xa genes viz., Xa4, xa5, xa13, Xa21, Xa23, Xa27(t), Xa32(t), Xa33, Xa35(t), Xa38 and xa41 with gene-specific markers to ascertain the novelty. Some key resistance genes such as Xa4, Xa23, Xa27(t), Xa32(t), Xa33, Xa35(t) and xa41 were detected in multiple accessions, with O. rufipogon and O. eichingeri harbouring particularly complex combinations of these genes. Notably, several accessions viz., IC521672 (O. nivara), EC861665 (O. officinalis), EC861677 (O. latifolia), EC861711 (O. punctata) and EC861738 (O. eichingeri) did not show the presence of any known genes indicating the possibility of novel genetic loci conferring BB resistance in these wild species. These promising accessions identified in the study are potential novel sources for bacterial leaf blight resistance in rice and will be useful for the development of durable bacterial blight resistance rice cultivars.
Interview of James D. Riley
Authors: Harrison Jay T. 
Published: December 2024

AbstractJames D. Riley became the first lay editor of The Americas journal in 1987, leading the journal to its current status as a leading refereed academic publication of Latin American history and cultural studies. The interview addresses Riley’s formative years as a scholar, his work with the Academy of American Franciscan History and The Americas, and the transformation of the journal from 1987 to his retirement from the academy.
Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion
Authors: Jaspers Faijer-Westerink Hester , von Scheibler Emma N. M. M. , van Rossum Elisabeth F. C. , van Haelst Mieke M. , Vingerhoets Claudia , van Amelsvoort Thérèse A. M. J. , van Eeghen Agnies M. , Boot Erik 
Published: November 2024

Abstract
Objective
Copy number variations (CNVs) may contribute to medical conditions. However, research on the impact of individual CNVs on endocrine disease is limited. This study aimed to provide new data on obesity and metabolic syndrome (MetS) in adults with microdeletion 22q11.2, the pathogenic CNV associated with 22q11.2 deletion syndrome.

Methods
We examined prevalence rates of obesity and MetS in 103 adults with a typical 22q11.2 deletion (45.2% male, at median age 30.0 (range 17–71) years) and compared these rates with population-based data. Generalized obesity was defined by a body mass index (BMI) ≥ 30 kg/m2, abdominal obesity by a waist circumference (WC) of ≥102 cm in males and ≥88 cm in females, and MetS by standard Joint Interim Statement criteria. General linear models were used to examine the independent associations of age, sex, congenital heart defect, smoking, and antipsychotic use with BMI, WC, and the presence of MetS.

Results
Prevalence rates of generalized obesity (32.0%), abdominal obesity (51.5%), and MetS (33.0%) were significantly higher compared to a population-based cohort (15.7% (P < 0.0001), 36.1% (P = 0.002), and 15.2% (P < 0.0001), respectively). In antipsychotic naïve subjects, significant correlations were observed between age and BMI (r = 0.54, P < 0.001), and age and WC (r = 0.60, P < 0.001). These correlations were not present in individuals taking antipsychotic medication. The models predicting BMI (F(5, 97) = 3.083, R2 = 0.137, P = 0.01) and WC (F(5, 92) = 5.985, R2 = 0.245, P < 0.001) were significant. Only age was individually predictive of outcomes (P < 0.05 and P < 0.001). The model predicting MetS was also significant (P < 0.001), with higher age being the only factor associated with MetS (OR = 1.07, 95% CI = 1.03–1.12, P < 0.001).

Conclusions
Generalized and abdominal obesity, as well as MetS, appear to be common in adults with 22q11.2 deletion syndrome, emphasizing the importance of careful monitoring from a young age. These findings contribute to the limited knowledge about the association between pathogenic CNVs, obesity, and MetS.
Identification of biallelic POLA2 variants in two families with an autosomal recessive telomere biology disorder
Authors: Kvarnung Malin , Pettersson Maria , Chun-on Pattra , Rafati Maryam , McReynolds Lisa J. , Norberg Anna , Moura Pedro Luis , Pesonen Ida , Chaireti Roza , Grönros Söderholm Boa , Burlin Julia , Rydén Jenny , Lindberg Eva Hellström , Giri Neelam , Savage Sharon A. , Agarwal Suneet , Nordgren Ann , Tesi Bianca 
Published: November 2024

AbstractPOLA2 encodes the accessory subunit of DNA polymerase α (polα)/primase, which is crucial for telomere C-strand fill-in. Incomplete fill-in of the C-rich telomeric strand after DNA replication has been proposed as a mechanism for Coats plus syndrome, a phenotype within the broader spectrum of telomere biology disorders (TBD). Coats plus syndrome has so far been associated with pathogenic variants in POT1, CTC1, and STN1. Here we report the findings of biallelic deleterious rare variants in POLA2 gene detected by whole genome sequencing and segregation analysis in five young adults from two unrelated families. All five individuals displayed abnormally short telomeres and a clinical phenotype suggesting a TBD disorder with Coats plus features including retinal and gastrointestinal telangiectasias. Our results suggest POLA2 as a novel autosomal recessive gene for a TBD with Coats plus features.
A multicenter trial on the predictors of different subtypes of hemorrhagic infarction after thrombolysis
Authors: Zeinhom Mohamed G. , Ahmed Sherihan Rezk , Kohail Ahmed Mohamed , Kamel Islam Fathallah Mohamed , Abdelrahman ALshimaa Mahfouz , AL-Nozha Omar M. , Almoataz Mohamed , Youssif Tarek Youssif Omar , Daabis Ahmed Mohamed Ali , Refat Hossam Mohamed , Ebied Ahmed Ahmed Mohamed Kamal , Elbassiouny Ahmed , Akl Ahmed Zaki Omar , Shuaib Ashfaq , Ismaiel Mohamed , Ibrahem Asmaa Ibrahem Desouky Mostafa , Khalil Mohamed Fouad Elsayed 
Published: November 2024

AbstractWorldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. Most studies evaluated the post-alteplase haemorrhagic transformation of brain infarction as a homogeneous entity but we evaluated the predictors of each subtype of haemorrhagic transformation of brain infarction. Our trial included 616 AIS alteplase-treated patients. We evaluated the ability of different risk factors, clinical presentation, and imaging features to predict different haemorrhagic transformation (HT) subtypes. HT was seen in 152 patients (24.7%), higher NIHSS, cardioembolic stroke and atrial fibrillation were independent predictors of all ECASS-based subtypes of hemorrhagic infarction, in addition, anterior-circulation stroke was an independent predictor of hemorrhagic infarction type 1 (odds ratio [OR], 11.04; 95% CI, 9.81 to 12.70; P-value > 0.001) and type2 (OR, 11.89; 95% CI, 9.79 to 14.44; P-value > 0.001), while older age was also an independent predictor of parenchymal hematoma type1 (OR, 1.312; 95% CI, 1.245 to 1.912; P-value 0.02). In AIS patients treated with alteplase in Egypt and Saudi Arabia, higher NIHSS, cardioembolic stroke and atrial fibrillation were independent predictors of all ECASS-based subtypes of hemorrhagic infarction; in addition, anterior-circulation stroke was an independent predictor of hemorrhagic infarction type 1 and 2, while older age was also an independent predictor of parenchymal hematoma type1. Trial registration: (clinicaltrials.gov NCT06337175), retrospectively registered on 29/03/2024.
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
Authors: Kubisiak Agata , Dabrowska Agnieszka , Botwina Pawel , Twardawa Patrycja , Kloska Damian , Kołodziej Tomasz , Rajfur Zenon , Pyrc Krzysztof , Targosz-Korecka Marta 
Published: November 2024

AbstractClinical data indicate that COVID-19 causes cardiovascular complications, regardless of the severity of the disease. In this work, we have shown that SARS-CoV-2 infection causes vascular dysfunction due to the modification of endothelial cell elasticity. We used human pulmonary endothelial cells (HPAECs) expressing the ACE2 receptor as a model of the endothelium. This system mimics in vivo conditions, as it allows virus entry but not replication. As a reference, we used A549 epithelial cells, a well-described model that supports productive replication of SARS-CoV-2. We show that the infection of HPAECs results in loss of cell elasticity, which correlates with increased polymerization of actin filaments and induction of the inflammatory response. On the contrary, A549 epithelial cells supporting viral replication showed increased elasticity. We also showed that the endothelial cell elasticity were impaired after infection with Alpha, Beta and Delta variants. Consequently, we believe that nonproductive SARS-CoV-2 infection associated with loss of the endothelium elasticity may be clinically relevant and result in dysfunction and damage to this tissue.
Physical Activity and Sedentary Behavior on Bone Health in Adults: A
Systematic Review
Authors: da Costa Julio Cesar , Barbosa Cynthia Correa Lopes , Pelegrini Andreia , Serassuelo Junior Hélio , Gomez-Campos Rossana Anelice , Fernandes Rómulo Araujo , Ronque Enio Ricardo Vaz 
Published: November 2024

AbstractThe objective was to analyze the longitudinal associations of physical activity
(PA) and Sedentary behavior (SB) on bone health indicators (BHI) in healthy
young adults. Articles were selected from five databases and 17 longitudinal
studies were selected after meeting the inclusion and exclusion criteria. Among
these, only one study assessed the association between childhood PA and adult
BHI, the results showed no significant association between PA and BHI. Positive
associations between adolescence and adulthood were observed between PA with
bone mineral content and density and bone microarchitecture. In adulthood, the
results were divergent; among the three studies located, two found a positive
association. SB was negatively associated with bone mineral density and content
from childhood to adulthood. However, from adolescence to adulthood, it was
negatively associated with total tibia area but positively associated with
trabecular thickness, cortical thickness, and cortical bone mineral. The
evidence of the positive effect of PA and its intensities between adolescence
and adulthood on BHI seems to be more consolidated, and it is still necessary to
understand the role of intensities, volume of PA and SB in different periods of
life with BHI in adulthood.
Overall Accuracy of the Modified Duke Criteria—A Systematic Review and Meta-analysis
Authors: Caldonazo Tulio , Tasoudis Panagiotis , Doenst Torsten , Moris Dimitrios , Kang Lillian , Moschovas Alexandros , Kirov Hristo , Treml Ricardo E. , Sá Michel Pompeu , Hagel Stefan , Diab Mahmoud 
Published: November 2024

Abstract
Background Rapid and accurate diagnosis of infective endocarditis (IE) allows timely management of this life-threatening disease and improves outcome. The Duke criteria have traditionally been the clinical method for diagnosing IE. These criteria were reformulated at different timepoints. We aimed to evaluate the real accuracy of the modified Duke criteria based on several studies that concluded the diagnosis of IE.
Methods Three databases were assessed. Studies were considered for inclusion if they reported the use of modified Duke criteria as the initial approach and the confirmation of the diagnosis with the gold standard methods. The meta-analysis of diagnostic test accuracy was performed after fitting the hierarchical summary receiver operating characteristic model (HSROC) with bivariate model and displaying the summarized measures of sensitivity and specificity, and positive and negative likelihood ratios.
Results A total of 11 studies were included. Accuracy in the included studies ranged from 62.3 to 92.2%, sensitivity ranged from 58.3 to 84.0%, and specificity ranged from 50.0 to 100%. The combined overall sensitivity and specificity were 85% (95% CI: 0.77–0.90) and 98% (95% CI: 0.89–0.99), respectively. The positive likelihood ratio was 40.2 (95% CI: 7.26–220.74) and the negative likelihood ratio was 0.15 (95% CI: 0.01–0.23).
Conclusion The analysis reveals that the modified Duke criteria have a high positive likelihood ratio, suggesting a robust correlation between a positive test result and the existence of IE, and a very good overall specificity at 98%. The latter aspect holds significant importance in order to prevent unnecessary overtreatment, given the intricacies involved in managing IE.
Assessing NATO’s cohesion: methods and implications
Authors: Kunertova Dominika , Schmitt Olivier 
Published: November 2024

AbstractWhile united in initial responses to Putin’s aggression in Ukraine, NATO members face challenges as the alliance adapts to a significantly worsened security environment. Although Russia’s war in Ukraine provided NATO with a unifying threat, we argue that external factors are not sufficient to maintain its cohesion. This forum contribution develops a conceptual tool to assess alliance cohesion across both political and military dimensions, thus highlighting the agency of the “architects”, “bricoleurs”, and “agnostics” in shaping NATO’s internal politics. This approach allows for estimating the degree to which allies coordinate their political objectives, as well as the effectiveness of strategies to achieve them. To estimate the strength of alliance cohesion, we introduce four cohesion drivers—security threats, norms, institutions, and leadership—and assessment criteria. This article outlines three scenarios modelled on the war in Ukraine, suggesting that alliance cohesion suffers the most during prolonged security crises. Using this assessment tool can provide the “architects” of European security with ideas for policies aimed at strengthening NATO cohesion.
Towards a reconstruction of Proto-Coastal Min voiced coronal affricate and fricative initials
Authors: Kwok Bit-Chee 
Published: December 2024

Abstract
In this paper, we compare the corresponding sets across the Coastal Min dialects and reconstruct three voiced coronal initials, namely, *dʒ-, dʒh- and *ð-, for Proto-Coastal Min. The main reason of reconstructing voiced initials is that the Eastern Min varieties have undergone fricativization of some earlier affricates, which only occur in the yang tonal register. The development of these initials in modern languages is also discussed. It is found that while the Pu-Xian dialects share some similar features with Eastern Min regarding the initials under discussion, there is no strong reason to assume that they are genetically closer within the Coastal Min family.
On the finiteness of complement clauses in Chinese
Authors: Hu Bo , Chen Hong 
Published: December 2024

Abstract
This paper investigates the finiteness of complement clauses in
Chinese within the theoretical framework of the Minimalist Program, with a
specific focus on the independency and opacity features. Following He (2020) and Huang (2022), this study proposes that the feature
[IND] represents the independent reference time of the complement clause, and
the feature [OPA] indicates the degree of opacity for syntactic operations. By
integrating these two features, the paper establishes a robust differentiation
between finiteness and nonfiniteness within Chinese complement clauses. Under
the assumption that all complement clauses in Chinese are CP, a propositional CP
is classified as finite when its Co head is positively specified for
both features [+IND, +OPA]. Conversely, an event/action CP is considered
nonfinite when the Co head carries a negative specification: [+ IND, −OPA] or
[−IND, −OPA]. It is worth noting that if the reference time of a complement
clause depends on the matrix clause, it cannot be opaque, and therefore exhibits
transparency. This research sheds light on the intricate relationship between
the independency and opacity features, providing valuable insights into the
syntactic mechanisms underlying complement clauses in Chinese.
Detecting the stochastic gravitational wave background from primordial black holes in slow-reheating scenarios
Authors: Padilla Luis E. , Hidalgo Juan Carlos , Malik Karim A. , Mulryne David 
Published: December 2024

Abstract
After primordial inflation, the universe may have experienced a prolonged reheating epoch, potentially leading to a phase of matter domination supported by the oscillating inflaton field. During such an epoch, perturbations in the inflaton virialize upon reentering the cosmological horizon, forming inflaton structures. If the primordial overdensities are sufficiently large, these structures collapse to form primordial black holes (PBHs).
To occur at a significant rate, this process requires an enhanced primordial power spectrum (PPS) at small scales.
The enhancement of the PPS, as well as the formation and tidal interaction of the primordial structures, will in turn source a stochastic gravitational wave background (SGWB)
that could be detected by current and/or future gravitational wave detectors.
In this paper, we study the SGWB arising from these different sources
during slow-reheating, focusing
on a PPS that satisfies the requirements necessary for the formation of PBHs with a mass of MPBH ≃ 1021 and that constitute the entirety of dark matter in the universe.
Compression optical coherence elastography as a new tool for non-invasive identification of precancerous lesions of the oral mucosa
Authors: Plekhanov Anton A , Gazhva Svetlana I , Ibragimova Yuliya S , Sovetsky Alexander A , Mishina Natalia V , Potapov Arseniy L , Matveev Lev A , Kalinkin Kirill I , Anina Anastasia A , Matveyev Alexander L , Sirotkina Marina A , Gladkova Natalia D , Zaitsev Vladimir Y 
Published: December 2024

Abstract
We demonstrate the possibilities and prospects of a new application of compression optical coherence elastography (C-OCE) for diagnosing precancerous lesions of the oral mucosa. C-OCE allows the study of nonlinear elasticity of bio-tissues and mapping of various elasticity parameters to differentiate individual morphological structures and pathologies in human tissues. This work demonstrates the first utilization of C-OCE to identify oral leukoplakia lesions in the palate and buccal mucosa using changes in epithelial stiffness caused by the development of hyperkeratosis, which leads to the appearance of a pronounced keratin layer on the surface of the lesions. C-OCE-based quantification of characteristic stiffness values makes it possible to differentiate various types of hyperkeratosis in proliferative verrucous leukoplakia lesions, such as orthohyperkeratosis and corrugated keratosis. Quantification of the dimensionless nonlinear elastic parameter

β

additionally enables differentiation of the keratin layer from the epithelial layer in proliferative verrucous leukoplakia lesions with corrugated keratosis. The first reported results obtained for excised tissue samples substantiate the prospects of C-OCE for the realization of new clinical tools for non-invasive diagnosis of oral pathologies.
Comparison of Urine Output Response of Intravenous Bumetanide and Furosemide in Acute Decompensated Heart Failure: an observational analysis
Authors: Kefer Emily , Gulbis Brian , Weeks Phillip 
Published: December 2024

Loop diuretics are a fundamental cornerstone in management of hypervolemia encountered in acute decompensated heart failure. There is variation in literature describing relative potency of loop diuretic agents, and very limited available data specific to the heart failure population. In this retrospective cohort study, we aimed to compare the urine output response between intravenous furosemide and bumetanide in patients with acute decompensated heart failure.
Patients were eligible for inclusion if they were admitted between July 1, 2021 and June 30, 2022, with acute decompensated heart failure and received intravenous bumetanide or furosemide within 48 hours of admission. Propensity matching was utilized to determine comparison groups. The primary outcome was total urine output for 24 hours following initiation of the diuretic regimen.
A total of 120 patients (60 in each group) were matched after exclusion criteria were applied. The total urine output was similar between groups. The bumetanide group did demonstrate a greater urine output: furosemide equivalent response (52 ± 46 mL/mg versus 33 ± 25 mL/mg; p=0.007).
Based on our analysis, similar urine output may be achieved with either intravenous bumetanide or furosemide in acute decompensated heart failure; however a higher dose of furosemide may be required than what has been previously established as an equivalent dose to bumetanide to achieve a similar diuretic effect. These results should warrant further investigation to better establish dose-response relationships with loop diuretics in the acute decompensate heart failure.