bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal cocaine exposure: An examination of childhood externalizing and internalizing behavior problems at age 7 years
Authors: Accornero Veronica H. , Anthony James C. , Morrow Connie E. , Xue Lihua , Bandstra Emmalee S. 
Published: May 2019

SUMMARYAim – This study examines the relationship between prenatal cocaine exposure and parent-reported child behavior problems at age 7 years. Methods – Data are from 407 African-American children (210 cocaine-exposed, 197 non-cocaine-exposed) enrolled prospectively at birth in a longitudinal study on the neurodevelopmental consequences of in utero exposure to cocaine. Prenatal cocaine exposure was assessed at delivery through maternal self-report and bioassays (maternal and infant urine and infant meconium). The Achenbach Child Behavior Checklist (CBCL), a measure of childhood externalizing and internalizing behavior problems, was completed by the child's current primary caregiver during an assessment visit scheduled when the child was seven years old. Results – Structural equation and GLM/GEE models disclosed no association linking prenatal cocaine exposure status or level of cocaine exposure to child behavior (CBCL Externalizing and Internalizing scores or the eight CBCL sub-scale scores). Conclusions – This evidence, based on standardized ratings by the current primary caregiver, fails to support hypothesized cocaine-associated behavioral problems in school-aged children with in utero cocaine exposure. A next step in this line of research is to secure standardized ratings from other informants (e.g., teachers, youth self-report).Declaration of Interest: This research was conducted in the context of an ongoing longitudinal study funded by the National Institutes of Health National Institute on Drug Abuse (R01 DA 06556). Support was also provided by a NIDA career development award (K01 DA 16720), a NIDA research training award (T32 DA 07292), the General Clinical Research Center (MOI RR 16587), and the Health Foundation of South Florida.
Resilience in Extremely Preterm/Extremely Low Birth Weight Kindergarten Children
Authors: Taylor H. Gerry , Minich Nori , Schluchter Mark , Espy Kimberly Andrews , Klein Nancy 
Published: May 2019

AbstractObjectives:Research on developmental outcomes of preterm birth has traditionally focused on adverse effects. This study investigated the prevalence and correlates of resilience in 146 extremely preterm/extremely low birth weight (EPT/ELBW) children (gestational age &lt;28 weeks and/or birth weight &lt;1000 g) attending kindergarten and 111 term-born normal birth weight (NBW) controls.Methods:Adaptive competence (i.e., “resilience” in the EPT/ELBW group) was defined by scores within grade expectations on achievement tests and the absence of clinically elevated parent ratings of child behavior problems. The “adaptive” children who met these criteria were compared to the “maladaptive” children who did not on child and family characteristics. Additional analyses were conducted to assess the conjoint effects of group (ELBWvs. NBW) and family factors on adaptive competence.Results:A substantial minority of the EPT/ELBW group (45%) were competent compared to a majority of NBW controls (73%), odds ratio (95% confidence interval)=0.26 (0.15, 0.45),p&lt;.001. Adaptive competence was associated with higher cognitive skills, more favorable ratings of behavior and learning not used to define adaptive competence, and more advantaged family environments in both groups, as well as with a lower rate of earlier neurodevelopmental impairment in the EPT/ELBW group. Higher socioeconomic status and more favorable proximal home environments were associated with competence independent of group, and group differences in competence persisted across the next two school years.Conclusions:The findings document resilience in kindergarten children with extreme prematurity and highlight the role of environmental factors as potential influences on outcome. (JINS, 2019,25, 362–374)
What do Kids with Acquired Brain Injury Want? Mapping Neuropsychological Rehabilitation Goals to the International Classification of Functioning, Disability and Health
Authors: McCarron Robyn Henrietta , Watson Suzanna , Gracey Fergus 
Published: May 2019

AbstractObjective: To increase understanding of the community neuropsychological rehabilitation goals of young people with acquired brain injuries (ABIs). Method: Three hundred twenty-six neuropsychological rehabilitation goals were extracted from the clinical records of 98 young people with ABIs. The participants were 59% male, 2–19 years old, and 64% had a traumatic brain injury. Goals were coded using the International Classification of Functioning, Disability and Health: Children and Youth Version (ICF-CY). Descriptive statistical analysis was performed to assess the distribution of goals across the ICF-CY. Chi-squared and Cramer’s V were used to identify demographic and injury-related associations of goal type. Results: The distribution of goals was 52% activities and participation (AP), 28% body functions (BF), 20% environmental factors (EF), and &lt;1% body structures (BS). The number of EF goals increased with age at assessment (V = .14). Non-traumatic causes of ABIs were associated with more EF goals (V = .12). There was no association between sex or time post-injury and the distribution of goals across the ICF-CY. Conclusions: Young people with ABIs have a wide range of community neuropsychological rehabilitation goals that require an individualized, context-sensitive, and interdisciplinary approach. Community neuropsychological rehabilitation services may wish to ensure they are resourced to focus intervention on AP, with increasing consideration for EF as a young person progresses through adolescence. The findings of this research support models of community neuropsychological rehabilitation that enable wellness by combining direct rehabilitative interventions with attention to social context and systemic working across agencies. (JINS, 2019, 25, 403–412)
LOCALLY ANALYTIC VECTORS AND OVERCONVERGENT -MODULES
Authors: Gao Hui , Poyeton Léo 
Published: May 2019

AbstractLet$p$be a prime, let$K$be a complete discrete valuation field of characteristic$0$with a perfect residue field of characteristic$p$, and let$G_{K}$be the Galois group. Let$\unicode[STIX]{x1D70B}$be a fixed uniformizer of$K$, let$K_{\infty }$be the extension by adjoining to$K$a system of compatible$p^{n}$th roots of$\unicode[STIX]{x1D70B}$for all$n$, and let$L$be the Galois closure of$K_{\infty }$. Using these field extensions, Caruso constructs the$(\unicode[STIX]{x1D711},\unicode[STIX]{x1D70F})$-modules, which classify$p$-adic Galois representations of$G_{K}$. In this paper, we study locally analytic vectors in some period rings with respect to the$p$-adic Lie group$\operatorname{Gal}(L/K)$, in the spirit of the work by Berger and Colmez. Using these locally analytic vectors, and using the classical overconvergent$(\unicode[STIX]{x1D711},\unicode[STIX]{x1D6E4})$-modules, we can establish the overconvergence property of the$(\unicode[STIX]{x1D711},\unicode[STIX]{x1D70F})$-modules.
Coherent J-Band radiating arrays based on ×27 CMOS activemultiplier chips
Authors: Klimovich Roman , Jameson Samuel , Socher Eran 
Published: May 2019

AbstractThis paper presents a hybrid design of 1 × 2 and 1 × 4 arrays operating in 0.277–0.292 THz on 65 nm Complementary metal–oxide–semiconductor (CMOS) technology. Each of the chips has an X-band input with 3 ×3 multiplier stages and connected at the output to an on-chip ring antenna. A wideband microstrip Wilkinson four-way and two-way power dividers have been developed on a multilayer printed circuit board to feed the array elements with proper radio frequency and direct current inputs. Demonstrating improvements in effective isotropically radiated power and in total radiated power compared to a single CMOS element, the hybrid integration approach proves effective in implementing coherent THz transmitter arrays. Theoretical and practical factors that reduce the radiated power compared with ideal arrays are also discussed.
A tunable open ring coupling structure and its application in fully tunable bandpass filter
Authors: Zhang Zhonghai , Zhao Fei , Wu Aiting 
Published: May 2019

AbstractThis letter presents a novel tunable coupling structure to simplify the design complexity of the miniaturized fully tunable filter by using open ring and varactors. Based on the proposed novel tunable coupling structure, a fully tunable bandpass filter is implemented with independently tunable operating frequency and bandwidth. The tunable resonator and tunable coupling structure can be easily combined to improve Out-of-band suppression performance. The design procedure of a fully tunable bandpass filter consists of five tunable cavities and tunable coupling rings is also proposed. A prototype of the proposed fully tunable filter is built to verify the design experimentally. Good agreement between simulated and measured results is obtained.
Design and characterization of a 6–18 GHz GaN on SiC high-power amplifier MMIC for electronic warfare
Authors: Oreja Gigorro Eduardo , Delgado Pascual Emilio , Sánchez Martínez Juan José , Gil Heras María Luz , Bueno Fernández Virginia , Bódalo Márquez Antonio , Grajal Jesús 
Published: May 2019

AbstractA 6–18 GHz high-power amplifier (HPA) design in GaN on SiC technology is presented. This power amplifier consists of a two-stage corporate amplifier with two and four transistors, respectively. It has been fabricated on UMS using their 0.25 µm gate length process, GH25. A study of the suitable attachment method and measurement on wafer and on jig are detailed. This HPA exhibits an averaged output power of 39.2 dBm with a mean gain of 11 dB in saturation and a 24.5% maximum power added efficiency in pulse mode operation with a duty cycle of 10% with a 25 µs pulse width.
Analysis of Water Vapor Absorption in the Far‐Infrared and Submillimeter Regions Using Surface Radiometric Measurements From Extremely Dry Locations
Authors: Mlawer E. J. , Turner D. D. , Paine S. N. , Palchetti L. , Bianchini G. , Payne V. H. , Cady‐Pereira K. E. , Pernak R. L. , Alvarado M. J. , Gombos D. , Delamere J. S. , Mlynczak M. G. , Mast J. C. 
Published: May 2019

AbstractThe second Radiative Heating in Underexplored Bands Campaign (RHUBC‐II) was conducted in 2009 by the U.S. Department of Energy Atmospheric Radiation Measurement program to improve water vapor spectroscopy in the far‐infrared spectral region. RHUBC‐II was located in an extremely dry region of Chile to ensure very low opacities in this spectral region. Spectrally resolved measurements by a far‐infrared spectrometer and a submillimeter interferometer from RHUBC‐II are compared with line‐by‐line radiative transfer model calculations. Water vapor amounts and temperatures used in the calculations come from collocated radiosondes, with extensive adjustments to correct for issues due to the campaign's dry conditions and mountainous terrain. A reanalysis is also performed of far‐infrared measurements taken at the Atmospheric Radiation Measurement North Slope of Alaska site before and during the first RHUBC campaign. These analyses determine that differences between the measurements and model calculations using existing spectroscopic parameters are significant in the far‐infrared and submillimeter regions, leading to the derivation of improved water vapor continuum absorption coefficients and air‐broadened widths of 74 water vapor lines. The foreign continuum is increased by more than 50% in part of the far‐infrared and the widths of more than 20 lines are changed by more than 10%. The uncertainty in the foreign continuum coefficients is estimated as greater than 20% in some spectral regions, primarily a consequence of the uncertainty in the specification of water vapor. The improved far‐infrared spectroscopic parameters have a notable impact on calculated spectral radiances and a modest impact on broadband radiative fluxes and heating rates.
Predictive genomic traits for bacterial growth in culture versus actual growth in soil
Authors: Li Junhui , Mau Rebecca L , Dijkstra Paul , Koch Benjamin J , Schwartz Egbert , Liu Xiao-Jun Allen , Morrissey Ember M , Blazewicz Steven J , Pett-Ridge Jennifer , Stone Bram W , Hayer Michaela , Hungate Bruce A 
Published: May 2019

Abstract
Relationships between microbial genes and performance are often evaluated in the laboratory in pure cultures, with little validation in nature. Here, we show that genomic traits related to laboratory measurements of maximum growth potential failed to predict the growth rates of bacteria in unamended soil, but successfully predicted growth responses to resource pulses: growth increased with 16S rRNA gene copy number and declined with genome size after substrate addition to soils, responses that were repeated in four different ecosystems. Genome size best predicted growth rate in response to addition of glucose alone; adding ammonium with glucose weakened the relationship, and the relationship was absent in nutrient-replete pure cultures, consistent with the idea that reduced genome size is a mechanism of nutrient conservation. Our findings demonstrate that genomic traits of soil bacteria can map to their ecological performance in nature, but the mapping is poor under native soil conditions, where genomic traits related to stress tolerance may prove more predictive. These results remind that phenotype depends on environmental context, underscoring the importance of verifying proposed schemes of trait-based strategies through direct measurement of performance in nature, an important and currently missing foundation for translating microbial processes from genes to ecosystems.
Resource heterogeneity structures aquatic bacterial communities
Authors: Muscarella Mario E , Boot Claudia M , Broeckling Corey D , Lennon Jay T 
Published: May 2019

Abstract
Microorganisms are strongly influenced by the bottom-up effects of resource supply. While many species respond to fluctuations in the concentration of resources, microbial diversity may also be affected by the heterogeneity of the resource pool, which often reflects a mixture of distinct molecules. To test this hypothesis, we examined resource–diversity relationships for bacterioplankton in a set of north temperate lakes that varied in their concentration and composition of dissolved organic matter (DOM), which is an important resource for heterotrophic bacteria. Using 16S rRNA transcript sequencing and ecosystem metabolomics, we documented strong relationships between bacterial alpha-diversity (richness and evenness) and the bulk concentration and the number of molecules in the DOM pool. Similarly, bacterial community beta-diversity was related to both DOM concentration and composition. However, in some lakes the relative abundance of resource generalists, which was inversely related to the DOM concentration, may have reduced the effect of DOM heterogeneity on community composition. Together, our results demonstrate the potential metabolic interactions between bacteria and organic matter and suggest that changes in organic matter composition may alter the structure and function of bacterial communities.
Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
Authors: Jones Nicholas , Vincent Emma E. , Cronin James G. , Panetti Silvia , Chambers Megan , Holm Sean R. , Owens Sian E. , Francis Nigel J. , Finlay David K. , Thornton Catherine A. 
Published: May 2019

AbstractMetabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosphorylation (OXPHOS), in comparison to naïve T-cells. Despite having low resting metabolic rates, naive T-cells respond to TCR stimulation with robust and rapid increases in glycolysis and OXPHOS. This early metabolic switch requires Akt activity to support increased rates of glycolysis and STAT5 activity for amino acid biosynthesis and TCA cycle anaplerosis. Importantly, both STAT5 inhibition and disruption of TCA cycle anaplerosis are associated with reduced IL-2 production, demonstrating the functional importance of this early metabolic program. Our results define STAT5 as a key node in modulating the early metabolic program following activation in naive CD4+ T-cells and in turn provide greater understanding of how cellular metabolism shapes T-cell responses.
Microbial coexistence through chemical-mediated interactions
Authors: Niehaus Lori , Boland Ian , Liu Minghao , Chen Kevin , Fu David , Henckel Catherine , Chaung Kaitlin , Miranda Suyen Espinoza , Dyckman Samantha , Crum Matthew , Dedrick Sandra , Shou Wenying , Momeni Babak 
Published: May 2019

AbstractMany microbial functions happen within communities of interacting species. Explaining how species with disparate growth rates can coexist is important for applications such as manipulating host-associated microbiota or engineering industrial communities. Here, we ask how microbes interacting through their chemical environment can achieve coexistence in a continuous growth setup (similar to an industrial bioreactor or gut microbiota) where external resources are being supplied. We formulate and experimentally constrain a model in which mediators of interactions (e.g. metabolites or waste-products) are explicitly incorporated. Our model highlights facilitation and self-restraint as interactions that contribute to coexistence, consistent with our intuition. When interactions are strong, we observe that coexistence is determined primarily by the topology of facilitation and inhibition influences not their strengths. Importantly, we show that consumption or degradation of chemical mediators moderates interaction strengths and promotes coexistence. Our results offer insights into how to build or restructure microbial communities of interest.
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
Authors: Xian Hongxu , Yang Qiaoyun , Xiao Lin , Shen Han-Ming , Liou Yih-Cherng 
Published: May 2019

AbstractMitophagy is the selective autophagic targeting and removal of dysfunctional mitochondria. While PINK1/Parkin-dependent mitophagy is well-characterized, PINK1/Parkin-independent route is poorly understood. Using structure illumination microscopy (SR-SIM), we demonstrate that the SNARE protein Syntaxin 17 (STX17) initiates mitophagy upon depletion of outer mitochondrial membrane protein Fis1. With proteomics analysis, we identify the STX17-Fis1 interaction, which controls the dynamic shuffling of STX17 between ER and mitochondria. Fis1 loss results in aberrant STX17 accumulation on mitochondria, which exposes the N terminus and promotes self-oligomerization to trigger mitophagy. Mitochondrial STX17 interacts with ATG14 and recruits core autophagy proteins to form mitophagosome, followed by Rab7-dependent mitophagosome-lysosome fusion. Furthermore, Fis1 loss impairs mitochondrial respiration and potentially sensitizes cells to mitochondrial clearance, which is mediated through canonical autophagy machinery, closely linking non-selective macroautophagy to mitochondrial turnover. Our findings uncover a PINK1/Parkin-independent mitophagic mechanism in which outer mitochondrial membrane protein Fis1 regulates mitochondrial quality control.
Nanomeshed Si nanomembranes
Authors: Han Xun , Seo Kyung Jin , Qiang Yi , Li Zeping , Vinnikova Sandra , Zhong Yiding , Zhao Xuanyi , Hao Peijie , Wang Shuodao , Fang Hui 
Published: May 2019

AbstractOne of the main challenges in stretchable electronics is to achieve high-performance stretchable semiconductors. Here, we introduce an innovative concept of nanomeshed semiconductor nanomembrane which can be regarded almost as intrinsically stretchable to conventional microelectronic layouts. By making a silicon film into homogeneous nanomeshes with spring-like nano traces, we demonstrated a high electron mobility of 50 cm2/V·s, and moderate stretchability with a one-time strain of 25% and cyclic strain of 14% after stretching for 1000 cycles, further improvable with optimized nanomesh designs. A simple analytic model covering both fractional material and trace sidewall surfaces well predicted the transport properties of the normally on silicon nanomesh transistors, enabling future design and optimizations. Besides potential applications in stretchable electronics, this semiconductor nanomesh concept provides a new platform for materials engineering and is expected to yield a new family of stretchable inorganic materials having tunable electronic and optoelectronic properties with customized nanostructures.
Regularity is not a key factor for encoding repetition in rapid image streams
Authors: Thunell Evelina , Thorpe Simon J. 
Published: May 2019

AbstractHuman observers readily detect targets and repetitions in streams of rapidly presented visual stimuli. It seems intuitive that regularly spaced repeating items should be easier to detect than irregularly spaced ones, since regularity adds predictability and in addition has ecological relevance. Here, we show that this is not necessarily the case, and we point out the intrinsic difficulty in addressing this question. We presented long RSVP streams of never-before-seen natural images containing repetition sequences; an image appearing six times interleaved by one or more non-repeating distractors, and asked participants to detect the repetitions and to afterwards identify the repeated images. We found that the ability to detect and memorize repeated images was preserved even with irregular sequences, and conclude that temporal regularity is not a key factor for detection and memory for repeating images in RSVP streams. These findings have implications for models of repetition processing.
MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes
Authors: Rasheed Zafar , Rasheed Naila , Abdulmonem Waleed Al , Khan Muhammad Ismail 
Published: May 2019

AbstractAbnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs) play a crucial role in human disorders including arthritis. In this study, we determined the effect of hsa-miR-125b-5p on interleukin (IL)-1β induced inflammatory genes in human osteoarthritic (OA) chondrocytes. Bioinformatics algorithms showed 3′untranslated region (3′UTR) of TRAF6 mRNA (NM_004620.3) has perfectly matched ‘seed-sequence’ for hsa-miR-125b-5p. Treatment of cells with IL-1β up-regulates TRAF6 mRNA and down-regulates hsa-miR-125b-5p expression. This negative correlation between TRAF6 and hsa-miR-125b-5p was verified by transfection with miR-125b mimic (pre-miR-125b). Moreover, transfection with miR-125b mimic caused marked inhibition of IL-1β-induced phosphorylation of p38-MAPK, JNK-MAPKs and ERK-MAPKs and also suppressed the nuclear levels of NF-κBp50, NF-κBp65 and inhibited the activation of IκBα. Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1β also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-γ, TGF-β1, IGFBP-1 and PGDF-BB. Importantly, this transfection also significantly inhibited IL-1β- induced MMP-13 expression/production. In short, this study concludes that hsa-miR-125b-5p acts as a negative co-regulator of inflammatory genes including MMP-13 via targeting TRAF6/MAPKs/NF-κB pathway in human OA chondrocytes.