bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of a Ferry Construction Project Using a Production- Oriented Design Methodology
Authors: Mascaraque-Ramírez Carlos , Para-González Lorena , Marco-Jornet Paloma 
Published: November 2018

In an increasingly globalized sector such as the naval construction sector, the search for reduction in execution terms and production costs becomes essential. With this aim, the vessel project should be analyzed globally and in conjunction with the installations in which it will be built. The present research includes a series of improvement proposals for the construction of a 78-m-long ferry, designed for the transport of 700 passengers and 590 lineal meters of cargo space. These improvements are focused on the standardization of equipment and components in the accommodation area and engine room, as well as in the general arrangement of these spaces, by orienting their design toward manufacturing. All this will lead to a series of results, which demonstrate that the correct application of these changes considerably reduces production time and, consequently, the costs associated with it. In parallel, this study analyzes the facilities of the shipyard, proposing changes in its workshops and identifying new business lines to improve the strategic situation of the organization.

1. Introduction
Historically, European shipyards have manufactured in their installations a great variety of ships, each one with a high component of technological innovation. The high quality of their products and their adaptability to custom orders from the ship owners have led the naval construction sector to be currently identified at an international level as a sector with highly differentiated products.
The impact that international competition has had in the last decades, and more recently the economic crisis and the file opening by the European Commission in relation to the old system of "tax lease" applied in Europe (Curtis 2014), reduced the level of new ships construction contracting in 2011. The published registers (LR-Lloyds-Fairplay 2015) about the new ship constructions places European manufacturers far from the construction volumes of Asian manufacturers in terms of compensated gross tonnage (CGT), which is a measure of the compensated gross arching related to the gross tonnage through a compensation coefficient for each ship type and size, which considers the construction complexity based on the manufacturing work hours needed.
The double role of pigmentation and convolute leaves in community assemblage of Amazonian epiphytic Lejeuneaceae
Authors: Mota de Oliveira Sylvia 
Published: November 2018

BackgroundEpiphytic bryophyte communities in the Amazon forest show a vertical gradient in species composition along the trunk of the host trees. The investigation of species traits related to this pattern has focused on the physiology of selected taxa with a clear preference for one of the extremes of the gradient. Although some species are indeed only found on the tree base or in the outer canopy, the vertical gradient is composed mainly by the variation in the abundances of species with a broader occurrence along the height zones. Therefore, this study approaches the differences among community assemblages, rather than among species, to test the role of morphological and dispersal traits on the establishment of the vertical gradient in species composition.MethodsA character state matrix was built for 104 species of the family Lejeuneaceae recorded as epiphytes in the Amazonian terra firme forests, and six binary traits supposed to influence species occurrence: dark pigmentation on leaves; ability to convolute leaves when drying; possession of thickened cell walls; reproduction mode (monoicous or dioicous); occurrence of asexual reproduction; and facultative epiphyllous habit. Based on a previous dataset on community composition along the vertical gradient, trait occurrences in random draws of the metacommunity was compared to trait occurrences in field data, in order to detect significant deviations in the different height zones.ResultsFour out of the six traits tested showed significantly higher or lower occurrence in the species composition of canopy and/or understory communities. Traits related to high dispersal ability did not vary much along the vertical gradient; although facultative epiphylls were overrepresented on tree base. Dark pigmentation and convolute leaves were significantly more frequent in the canopy communities, but also significantly less frequent in communities at the base of the tree.DiscussionDark pigmentation and convolute leaves seem to be advantageous for the establishment in the canopy zones. They may, respectively, prevent light damage and allow longer periods of photosynthesis. Interestingly, these traits occur randomly along the trunk, but are wiped out of communities on the tree base. In the relatively deep shade of the first meters of the understory, they possibly hamper net carbon gain, the first by darkening the leaf surface and the second by delaying desiccation—which can be damaging under high temperatures and low light. The fact that production of asexual propagules is not overrepresented in the most dynamic microenvironment along the gradient, the canopy, challenges current views of bryophyte life strategy theory.
Stereoselective catalysis controlled by a native leucine or variant isoleucine wing‐gatekeeper in 2‐haloacid dehalogenase
Authors: Feng Yanbin , Wang Yayue , Chu Huiying , Fan Yan , Cao Xupeng , Liu Yinghui , Li Guohui , Xue Song 
Published: November 2018

Comprehensively understanding enzymatic stereoselectivity will assist in the creation of new enzymes for producing optically pure compounds for chemical applications. The essential features for selecting enantiomers are controlled by particular residues or regions of the enzymes. We report a stereoselective mechanism in the D‐2‐haloacid dehalogenase HadD AJ1, in which L288 is identified as a gatekeeper in the access channel that strictly recognizes D‐enantiomers. Mutagenesis of L288 to isoleucine (I) enlarges the size of the channel and allows the enzyme to accommodate L‐enantiomers. Furthermore, the wing flip of I288 induces hydrophobic interactions with the L‐enantiomer and directly affects the catalytic efficiency. The results illustrate the dynamic catalytic mechanisms of Leu‐Ile gatekeepers and provide knowledge for unveiling the basis of stereospecificity in biocatalysts.
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The impact of alcohol intoxication on witness suggestibility immediately and after a delay
Authors: Evans Jacqueline R. , Schreiber Compo Nadja , Carol Rolando N. , Nichols‐Lopez Kristin , Holness Howard , Furton Kenneth G. 
Published: November 2018

SummaryIntoxicated witnesses are common, making it important to understand alcohol's impact on witness accuracy and suggestibility. Participants assigned to an immediate retrieval condition encoded and recalled in one of the three intoxication conditions: sober control, placebo, or intoxicated. Participants in the delayed retrieval condition were assigned to encode in one of the three intoxication conditions, returned a week later, and were assigned to retrieve in one of the three intoxication conditions. Intoxication condition at encoding was fully crossed with intoxication condition at retrieval in the delayed condition. Participants encoded a mock crime video and retrieved via a forced‐choice test, with answers already circled (purportedly by a prior participant); half of the precircled responses were incorrect. When recalling after a delay only, intoxication at encoding increased agreement with incorrect suggested answers and decreased accuracy. Results suggest intoxicated witnesses may benefit from being interviewed immediately rather than after a sobering delay.
Relaxor Behavior in Ordered Lead Magnesium Niobate (PbMg1/3Nb2/3O3) Thin Films
Authors: Shetty Smitha , Damodaran Anoop , Wang Ke , Yuan Yakun , Gopalan Venkat , Martin Lane , Trolier‐McKinstry Susan 
Published: November 2018

AbstractThe local compositional heterogeneity associated with the short‐range ordering of Mg and Nb in PbMg1/3Nb2/3O3 (PMN) is correlated with its characteristic relaxor ferroelectric behavior. Fully ordered PMN is not prepared as a bulk material. This work examines the relaxor behavior in PMN thin films grown at temperatures below 1073 K by artificially reducing the degree of disorder via synthesis of heterostructures with alternate layers of Pb(Mg2/3Nb1/3)O3 and PbNbO3, as suggested by the random‐site model. 100 nm thick, phase‐pure films are grown epitaxially on (111) SrTiO3 substrates using alternate target timed pulsed‐laser deposition of Pb(Mg2/3Nb1/3)O3 and PbNbO3 targets with 20% excess Pb. Selected area electron diffraction confirms the emergence of (1/2, 1/2, 1/2) superlattice spots with randomly distributed ordered domains as large as ≈150 nm. These heterostructures exhibit a dielectric constant of 800, loss tangents of ≈0.03 and 2× remanent polarization of ≈11 µC cm−2 at room temperature. Polarization–electric field hysteresis loops, Rayleigh data, and optical second‐harmonic generation measurements are consistent with the development of ferroelectric domains below 140 K. Temperature‐dependent permittivity measurements demonstrate reduced frequency dispersion compared to short range ordered PMN films. This work suggests a continuum between normal and relaxor ferroelectric behavior in the engineered PMN thin films.
Exploiting In Situ Redox and Diffusion of Molybdenum to Enable Thin‐Film Circuitry for Low‐Cost Wireless Energy Harvesting
Authors: Son Youngbae , Peterson Rebecca L. 
Published: November 2018

AbstractDirect additive fabrication of thin‐film electronics using a high‐mobility, wide‐bandgap amorphous oxide semiconductor (AOS) can pave the way for integration of efficient power circuits with digital electronics. For power rectifiers, vertical thin‐film diodes (V‐TFDs) offer superior efficiency and higher frequency operation compared to lateral thin‐film transistors (TFTs). However, the AOS V‐TFDs reported so far require additional fabrication steps and generally suffer from low voltage handling capability. Here, these challenges are overcome by exploiting in situ reactions of molybdenum (Mo) during the solution‐process deposition of amorphous zinc tin oxide film. The oxidation of Mo forms the rectifying contact of the V‐TFD, while the simultaneous diffusion of Mo increases the diode's voltage range of operation. The resulting V‐TFDs are demonstrated in a full‐wave rectifier for wireless energy harvesting from a commercial radio‐frequency identification reader. Finally, by using the same Mo film for V‐TFD rectifying contacts and TFT gate electrodes, this process allows simultaneous fabrication of both devices without any additional steps. The integration of TFTs alongside V‐TFDs opens a new fabrication route for future low‐cost and large‐area thin‐film circuitry with embedded power management.
Alkylamino‐Directed One‐Pot Reaction of N‐Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3‐Dihydroquinazolin‐4(1H)‐ones
Authors: Zhang Xiaopeng , Li Zhengwei , Ding Qianqian , Li Xiaochuan , Fan Xuesen , Zhang Guisheng 
Published: November 2018

AbstractAn economical and efficient approach to pharmaceutically and biologically significant 2,3‐dihydroquinazolin‐4(1H)‐ones has been disclosed. The one‐pot multicomponent reaction was performed through a palladium‐catalyzed ortho‐selective oxidative carbonylation of N‐substituted anilines with CO and primary amines, and subsequent condensation with aldehydes in MeCN by using alkylamino as the directing group, KI/AcOH as the additives, and Cu(OAc)2 as the oxidant. This intriguing straightforward method features embedded directing strategy, simple starting materials, mild conditions, high atom/step economic economy, broad substrate scope and good product diversity.magnified image
Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy
Authors: Chien Yi‐Hsin , Chan Kok Ken , Anderson Tommy , Kong Kien Voon , Ng Beng Koon , Yong Ken‐Tye 
Published: November 2018

AbstractCancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano‐sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near‐infrared (NIR) light‐responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light‐responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light‐responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation.
Magnetic Supramolecular Nanofibers of Gold Nanorods for Photothermal Therapy
Authors: Yu Qilin , Zhang Ying‐Ming , Liu Yao‐Hua , Liu Yu 
Published: November 2018

AbstractMolecular aggregation triggered by physical and chemical stimuli and based on multiple noncovalent interactions has immense potential utility for modeling and mimicking biological systems and for the diagnosis and treatment of degenerative diseases. Herein the preparation, properties, and biological activities of a new type of organic–inorganic hybrid supramolecular nanofiber composed of gold nanorods, mitochondrion‐targeting‐peptide‐coated iron oxide nanoparticles, and hyaluronic‐acid (HA)‐modified β‐cyclodextrin is reported. These photothermal nanofibers, which grew along the direction of the geomagnetic field, induced severe mitochondrial damage in human adenocarcinoma cells (A549); and, more strikingly, the nanofibers greatly suppress metastasis and clear A549 cells in tumor‐bearing mice upon irradiation with a near‐infrared laser. The ability to recruit HA‐receptor‐expressing tumor cells and to target mitochondria, as well as the high photothermal conversion efficiency imparted by the gold nanorods, makes these supramolecular nanofibers a promising nanotherapy for cancer in general and metastasis‐related malignancy in particular.
Modular Covalent Graphene Functionalization with C60 and the Endohedral Fullerene Sc3N@C80: A Facile Entry to Synthetic‐Carbon‐Allotrope Hybrids
Authors: Wei Tao , Martin Oliver , Yang Shangfeng , Hauke Frank , Hirsch Andreas 
Published: November 2018

AbstractTwo novel graphene‐fullerene hybrid structures, containing C60 and endohedral Sc3N@C80 bound to graphene, instead of the formerly used graphene oxide, were efficiently synthesized via a reductive activation/exfoliation approach starting from pristine graphite. The structures of these multifunctional hybrid systems were unambiguously characterized by statistical Raman spectroscopy, TG‐MS, TG‐GC‐MS, and LD‐TOF mass spectroscopy, confirming the covalent bonding of the respective C60/Sc3N@C80 moieties to the pristine graphene. Furthermore, assisted by temperature‐dependent Raman spectroscopy studies the corresponding defunctionalization processes were also investigated. Finally, the formation of a carbon allotrope hybrid material on the basis of C60/Sc3N@C80 moieties coupled to graphene could be visualized by HRTEM.
Prediction on the Origin of Selectivities in Base‐controlled Switchable NHC‐catalyzed Transformations
Authors: Wang Yang , Qu Ling‐Bo , Wei Donghui 
Published: November 2018

AbstractThe base‐controlled mechanisms for N‐heterocyclic carbene (NHC)‐catalyzed divergent [3+3] and [3+2] annulation reactions were examined by using the DFT method. The reaction initiates with the complexation of NHC and enal to give the Breslow intermediate, which diverges afterward. Then, the azomethine imine can either react with the Breslow intermediate to give the six‐membered ring product or the β‐carbon protonation occurs for forming the enolate intermediate controlled by different bases. The formed enolate intermediate reacts with azomethine imine to afford the five‐membered ring product. The calculated results show that only the base K2CO3 can facilitate the structural transformation between homoenolate and enolate to switch the chemoselectivity; therefore, the [3+3] annulation happens preferentially in the presence of base DBU while the other situation occurs with K2CO3 as base. The NCI analysis results reveal that the stereoselectivity is predominately determined by the π⋅⋅⋅π, C−H⋅⋅⋅O, and C−H⋅⋅⋅N interactions. The obtained mechanistic insights should provide valuable clues for the rational design of these kinds of divergent reactions.
Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics
Authors: Afewerki Samson , Sheikhi Amir , Kannan Soundarapandian , Ahadian Samad , Khademhosseini Ali 
Published: November 2018

AbstractGelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.
Helpful aspects of bereavement counselling: An interpretative phenomenological analysis
Authors: Simonsen Gurid , Cooper Mick 
Published: November 2018

AbstractAimThe purpose of this study was to deepen an understanding of the practices that bereaved clients find helpful in counselling.MethodSemi‐structured qualitative interviews were conducted with seven clients who had participated in counselling for bereavement within a voluntary organisation in Scotland. Data were thematically analysed within an overall framework of interpretative phenomenological analysis.FindingsRespondents identified five helpful aspects of counselling. First, the independence of the counsellor: That they were outside the family and social network. Second, the counsellor's skilled listening: Being attentive, welcoming, demonstrating competence and being ‘to the point’. Third, the non‐directivity of the counselling work: Being allowed to take the lead and to talk on a range of issues, both bereavement and non‐bereavement related. Fourth, having their unhelpful thinking challenged, being encouraged to see things from a broader perspective and through addressing their feelings of guilt and anger. Fifth, by having their responses to bereavement normalised through psycho‐education and therapist self‐disclosure.ConclusionThe findings support previous research which suggests that both more, and less, directive interventions can be helpful for clients who experience bereavement. This is consistent with a pluralistic perspective, which holds that no one therapeutic orientation has a monopoly on helpful therapeutic practices. The findings suggest that helpful practice with bereaved clients may involve a client‐led approach in which there is the establishment of a strong, supportive and attentive therapeutic relationship, but in which the therapist also brings in more directive interventions to help the client normalise and address their feelings.
Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase
Authors: Falcone Natashya , She Zhe , Syed Jebreil , Lough Alan , Kraatz Heinz‐Bernhard 
Published: November 2018

AbstractNicotinamide and pyridine‐containing conjugates have attracted a lot of attention in research as they have found use in a wide range of applications including as redox flow batteries and calcium channel blockers, in biocatalysis, and in metabolism. The interesting redox character of the compounds’ pyridine/dihydropyridine system allows them to possess very similar characteristics to the natural chiral redox agents NAD+/NADH, even mimicking their functions. There has been considerable interest in designing and synthesizing NAD+/NADH mimetics with similar redox properties. In this research, three nicotinamide conjugates were designed, synthesized, and characterized. Molecular structures obtained through X‐ray crystallography were obtained for two of the conjugates, thereby providing more detail on the bonding and structure of the compounds. The compounds were then further evaluated for biochemical properties, and it was found that one of the conjugates possessed similar functions and characteristics to the natural NADH. This compound was evaluated in the active enzyme, enoate reductase; like NADH, it was shown to help reduce the C=C double bond of three substrates and even outperformed the natural coenzyme. Kinetic data are reported.
Percutaneous management of periprocedural coronary sinus Reducer migration
Authors: Tzanis Georgios , Durante Alessandro , Mitomo Satoru , Giannini Francesco 
Published: November 2018

AbstractCoronary sinus Reducer represents a novel therapeutic option for refractory angina. As emerging evidence of both reduction in angina symptoms and reduction of myocardial ischemia burden might lead to increased Reducer implantations, knowledge on how to manage potential complications is of clinical importance. We report a successful management of scaffold migration in right atrium.