bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Year Results of a Medicare Advantage Cancer Management Program
Authors: Hoverman J. Russell , Neubauer Marcus A. , Jameson Melissa , Hayes Jad E. , Eagye Kathryn J. , Abdullahpour Mitra , Haydon Wendy J. , Sipala Maria , Supraner Amy , Kolodziej Michael A. , Verrilli Diana K. 
Published: March 2018

Purpose: Reform of cancer care delivery seeks to control costs while improving quality. Texas Oncology collaborated with Aetna to conduct a payer-sponsored program that used evidence-based treatment pathways, a disease management call center, and an introduction to advance care planning to improve patient care and reduce total costs. Methods: From June 1, 2013, to May 31, 2016, 746 Medicare Advantage patients with nine common cancer diagnoses were enrolled. Patients electing for patient support services were telephoned by oncology nurses who assessed symptoms and quality of life and introduced advance care planning. Shared cost savings were determined by comparing the costs of drugs, hospitalization, and emergency room use for 509 eligible patients in the study group with a matched cohort of 900 Medicare Advantage patients treated by non–Texas Oncology providers. Physician adherence to treatment pathways and performance and quality metrics were evaluated. Results: During the 3 years of the study, the cumulative cost savings were $3,033,248, and savings continued to increase each year. Drug cost savings per patient per treatment month were $1,874 (95% CI, $1,373 to $2,376; P < .001) after adjusting for age, diagnosis, and study year. Solid tumors contributed most of the savings; hematologic cancers showed little savings. For years 1, 2, and 3, adherence to treatment pathways was 81%, 84%, and 90%, patient satisfaction with patient support services was 94%, 93%, and 94%, and hospice enrollment was 55%, 57%, and 64%, respectively. Conclusion: A practice-based program supported by a payer sponsor can reduce costs while maintaining high adherence to treatment pathways and patient satisfaction in older patients.
Sounds of Crossing
Authors: Chávez Alex E. 
Published: March 2018

In Sounds of Crossing Alex E. Chávez explores the contemporary politics of Mexican migrant cultural expression manifest in the sounds and poetics of huapango arribeño, a musical genre originating from north-central Mexico. Following the resonance of huapango's improvisational performance within the lives of audiences, musicians, and himself—from New Year's festivities in the highlands of Guanajuato, Mexico, to backyard get-togethers along the back roads of central Texas—Chávez shows how Mexicans living on both sides of the border use expressive culture to construct meaningful communities amid the United States’ often vitriolic immigration politics. Through Chávez's writing, we gain an intimate look at the experience of migration and how huapango carries the voices of those in Mexico, those undertaking the dangerous trek across the border, and those living in the United States. Illuminating how huapango arribeño’s performance refigures the sociopolitical and economic terms of migration through aesthetic means, Chávez adds fresh and compelling insights into the ways transnational music-making is at the center of everyday Mexican migrant life.
Disrupting the three-dimensional regulatory topology of the Pitx1 locus results in overtly normal development
Authors: Sarro Richard , Kocher Acadia A. , Emera Deena , Uebbing Severin , Dutrow Emily V. , Weatherbee Scott D. , Nottoli Timothy , Noonan James P. 
Published: March 2018

ABSTRACT
Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers. However, identifying enhancers essential for the expression of their target genes has proven challenging. Maps of long-range regulatory interactions may provide the means to identify enhancers crucial for developmental gene expression. To investigate this hypothesis, we used circular chromosome conformation capture coupled with interaction maps in the mouse limb to characterize the regulatory topology of Pitx1, which is essential for hindlimb development. We identified a robust hindlimb-specific interaction between Pitx1 and a putative hindlimb-specific enhancer. To interrogate the role of this interaction in Pitx1 regulation, we used genome editing to delete this enhancer in mouse. Although deletion of the enhancer completely disrupts the interaction, Pitx1 expression in the hindlimb is only mildly affected, without any detectable compensatory interactions between the Pitx1 promoter and potentially redundant enhancers. Pitx1 enhancer null mice did not exhibit any of the characteristic morphological defects of the Pitx1−/− mutant. Our results suggest that robust, tissue-specific physical interactions at essential developmental genes have limited predictive value for identifying enhancer mutations with strong loss-of-function phenotypes.
Evolutionary divergence of the sex-determining gene MID uncoupled from the transition to anisogamy in volvocine algae
Authors: Geng Sa , Miyagi Ayano , Umen James G. 
Published: March 2018

ABSTRACT
Volvocine algae constitute a unique comparative model for investigating the evolution of oogamy from isogamous mating types. The sex- or mating type-determining gene MID encodes a conserved RWP-RK transcription factor found in either the MT− or male mating locus of dioecious volvocine species. We previously found that MID from the isogamous species Chlamydomonas reinhardtii (CrMID) could not induce ectopic spermatogenesis when expressed heterologously in Volvox carteri females, suggesting coevolution of Mid function with gamete dimorphism. Here we found that ectopic expression of MID from the anisogamous species Pleodorina starrii (PsMID) could efficiently induce spermatogenesis when expressed in V. carteri females and, unexpectedly, that GpMID from the isogamous species Gonium pectorale was also able to induce V. carteri spermatogenesis. Neither VcMID nor GpMID could complement a C. reinhardtii mid mutant, at least partly owing to instability of heterologous Mid proteins. Our data show that Mid divergence was not a major contributor to the transition between isogamy and anisogamy/oogamy in volvocine algae, and instead implicate changes in cis-regulatory interactions and/or trans-acting factors of the Mid network in the evolution of sexual dimorphism.
Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis
Authors: Verboon Jeffrey M. , Decker Jacob R. , Nakamura Mitsutoshi , Parkhurst Susan M. 
Published: March 2018

ABSTRACT
WASH, a Wiskott–Aldrich syndrome (WAS) family protein, has many cell and developmental roles related to its function as a branched actin nucleation factor. Similar to mammalian WASHC1, which is embryonic lethal, Drosophila Wash was found to be essential for oogenesis and larval development. Recently, however, Drosophila wash was reported to be homozygous viable. Here, we verify that the original wash null allele harbors an unrelated lethal background mutation; however, this unrelated lethal mutation does not contribute to any Wash oogenesis phenotypes. Significantly, we find that: (1) the homozygous wash null allele retains partial lethality, leading to non-Mendelian inheritance; (2) the allele's functions are subject to its specific genetic background; and (3) the homozygous stock rapidly accumulates modifications that allow it to become robust. Together, these results suggest that Wash plays an important role in oogenesis via the WASH regulatory complex. Finally, we show that another WAS family protein, SCAR/WAVE, plays a similar role in oogenesis and that it is upregulated as one of the modifications that allows the wash allele to survive in the homozygous state.
New Lower Bound and Exact Method for the Continuous Berth Allocation Problem
Authors: Xu Zhou , Lee Chung-Yee 
Published: March 2018

We study a continuous berth allocation problem, where incoming vessels need to be assigned a mooring time as well as a berth location on a quay. It is a crucial element in port planning to achieve quick turnaround time for vessels. To solve this problem, many solution methods have been developed in the literature. However, gaps between the best-known lower and upper bounds on its optimal solutions are far from close. In this paper, we propose new and more effective solution methods for this important problem. By introducing a novel relaxation of the problem, we have derived a new lower bound that can be computed efficiently in quadratic time. By incorporating this new lower bound with some new heuristic and pruning techniques, we have developed a new exact method, based on a branch-and-bound approach. To demonstrate general applicability of the proposed methods, we have extended them to a more complicated problem, where decisions on berth allocations are restricted by a quay crane constraint. Extensive computational results have shown that, compared with previous state-of-the-art methods, our new methods have significantly reduced gaps between the lower and upper bounds and have solved more and larger instances to optimality in significantly less time. We have also performed sensitivity tests to demonstrate how robust the new solutions are against uncertainties in particular input parameters. The online appendix is available at https://doi.org/10.1287/opre.2017.1687 .
Português e Redação: imprecisão de duas disciplinas de uma disciplina só
Authors: Mendonça Lívia Carvalho , Bulhões Ligia Pellon de 
Published: March 2018

Abordamos neste artigo a imprecisão dos currículos do Ensino Fundamental II regular de escolas públicas baianas que ofertam as disciplinas Redação e Língua Portuguesa, ou apenas Língua Portuguesa. Baseamo-nos em entrevistas feitas com professores de português da rede pública de educação do Estado da Bahia que atuam neste nível de ensino. Perguntamos que questões sobre a língua e os conteúdos de português estão na base desta imprecisão curricular. Citamos documento e autores que conceituam a língua de acordo com os seus aspectos discursivos e enunciativos, e não apenas em função de suas formas composicionais. Concluímos que as incongruências dos currículos para o ensino de português refletem os defeitos dos objetivos do ensino do português que estão postos pelo sistema escolar e que se confundem na imprecisão de duas disciplinas de uma disciplina só.
Por uma prática de leitura e escrita: uma experiência com o gênero fábula
Authors: Favorino Jeane Maria , El Fahl Alana De Oliveira Freitas 
Published: March 2018

O presente artigo apresenta e discute os resultados de uma proposta de intervenção pedagógica, por meio de sequência didática, aplicada na Escola Estadual Antônio Carlos Pedreira, localizada no município de São Gonçalo dos Campos, no Recôncavo Baiano. A proposta teve como objeto de ensino a mobilização do gênero fábula, visando proporcionar aos alunos do 6º ano do Ensino Fundamental II oportunidades para desenvolver sua competência discursiva. Defendemos as fábulas como um gênero textual/discursivo a ser trabalhado em sala de aula, pois, além de serem breves, transformam-se ao longo do tempo, permitem diversas maneiras de explorá-las e proporcionam discussões sobre diversas áreas de nossas práticas sociais. Os resultados obtidos evidenciam que, quando bem estimulados, os alunos conseguem desenvolver competências comunicativas para dentro e fora da sala de aula. Palavras-chave: Sequência didática. Fábulas. Leitura. Escrita.
Evidence of Oxidative Phosphorylation in Zebrafish Photoreceptor Outer Segments at Different Larval Stages
Authors: Calzia Daniela , Garbarino Greta , Caicci Federico , Pestarino Mario , Manni Lucia , Traverso Carlo Enrico , Panfoli Isabella , Candiani Simona 
Published: March 2018

Summary Previous studies on purified bovine rod outer segments (OS) disks pointed to Oxidative Phosphorylation (OXPHOS) as being the most likely mechanism involved in ATP production, as yet not fully understood, to support the first phototransduction steps. Bovine and murine rod OS disks, devoid of mitochondria, would house respiratory chain complexes I to IV and ATP synthase, similar to mitochondria. Zebrafish ( Danio rerio) is a well-suited animal model to study vertebrate embryogenesis as well as the retina, morphologically and functionally similar to its human counterpart. The present article reports fluorescence and Transmission Electron Microscopy colocalization analyses of respiratory complexes I and IV and ATP synthase with zpr3, the rod OS marker, in adult and larval zebrafish retinas. MitoTracker Deep Red 633 staining and assays of complexes I and III–IV activity suggest that those proteins are active in OS. Results show that an extramitochondrial aerobic metabolism is active in the zebrafish OS at 4 and 10 days of larval development, as well as in adults, suggesting that it is probably maintained during embryogenesis. Data support the hypothesis of an extramitochondrial aerobic metabolism in the OS of zebrafish.
Within- and Between-Session Reliability of the Isometric Midthigh Pull in Young Female Athletes
Authors: Moeskops Sylvia , Oliver Jon L. , Read Paul J. , Cronin John B. , Myer Gregory D. , Haff G. Gregory , Lloyd Rhodri S. 
Published: March 2018

Abstract
Moeskops, S, Oliver, JL, Read, PJ, Cronin, JB, Myer, GD, Haff, GG, and Lloyd, RS. Within- and between-session reliability of the isometric midthigh pull in young female athletes. J Strength Cond Res 32(7): 1892–1901, 2018—To investigate the within- and between-session reliability of the isometric midthigh pull (IMTP) in pre– and post–peak height velocity (PHV) female athletes. Nineteen pre- and 19 post-PHV athletes performed bilateral IMTPs using a custom-designed isometric testing system. Participants attended 3 separate testing sessions and performed 3 trials within each session. Peak force, relative peak force, force at 30, 50, 90, 100, 150, 200, and 250 ms, rate of force development (RFD) within time-specific bands, time to peak force (TPF), and time to peak RFD were obtained for analysis. Within- and between-session reliability for each variable was calculated from repeated-measures analysis of variance, intraclass correlation coefficients (ICCs), and coefficients of variation (CV) with 95% confidence intervals. Within- and between-session measures of absolute and relative peak force were found to be reliable for both pre-PHV (CV ≤ 9.4%, ICC ≥ 0.87) and post-PHV (CV ≤ 7.3%, ICC ≥ 0.92), but systematic bias was evident between sessions in the pre-PHV group, from session 1 to 2. Analyses of force at the specific time points revealed CVs between 19–37% and 5–24% for pre-PHV and post-PHV athletes, respectively. Greater variability was evident in TPF, and all RFD-related variables for pre-PHV (CV ≥ 38%) and post-PHV (CV ≥ 27%) athletes, respectively. The IMTP appears a reliable and safe method for evaluating peak force in young female athletes. Overall, post-PHV athletes were more reliable than pre-PHV athletes, with pre-PHV athletes needing additional familiarization to minimize the influence of systematic bias.
Educational Series in Congenital Heart Disease Congenital left-sided heart obstruction
Authors: Carr Michelle , Curtis Stephanie , Marek Jan 
Published: March 2018

Abstract
Congenital obstruction of the left ventricular outflow tract remains a significant problem and multilevel obstruction can often coexist. Obstruction can take several morphological forms and may involve the subvalvar, valvar or supravalvar portion of the aortic valve complex. Congenital valvar stenosis presenting in the neonatal period represents a spectrum of disorders ranging from the hypoplastic left heart syndrome to almost normal hearts. Treatment options vary dependent on the severity of the left ventricular outflow tract obstruction (LVOTO) and the variable degree of left ventricular hypoplasia as well as the associated lesions such as arch hypoplasia and coarctation.
Structure and Properties of Materials on the Basis of Ag-Pb-Sb-Te with High Thermоelectric Figure of Merit
Authors: Horichok I.V. , Nykyruy L.I. , Semko T.O. , Lopуanko M.A. , Sokolov O.L. , Galushchak M.O. 
Published: March 2018

The review of works devoted to the study of thermoelectric, thermodynamic and mechanical properties of highly efficient thermoelectric materials in the system Ag-Pb (Sn) -Sb-Te. It is shown that based on them can be obtained as n-, and district branches of thermoelectric converters with parameter dimensionless thermoelectric figure of merit ZT ≈ 1.5 - 2.0.
Habit, Symmetry and Orientation of Surface Structures Vapor - Phase Condensation SnTe:Bi on Ceramics
Authors: Saliy Ya.P. , Makovyshyn V.I. , Bylina I.S. , Bushkov N.I. 
Published: March 2018

The analysis was obtained by atomic force microscopy method of topograms nanostructures on the surface of vapor-phase condensation of SnTe: Bi, thet were opened deposited by evaporation in a vacuum on substrates of ceramics. With the distribution of polar and azimuthal angles of the normal vector to the surface elements of condensate was found objects with flat faces with by dominant orientation in space and by symmetry.
A Study of Electric Field Effect on Melting of Octadecane
Authors: Orlovskaya S.G. , Karimova F.F. , Shkoropado M.S. 
Published: March 2018

A new approach is developed to study melting kinetics of n-Octadecane. Modelling of heat transfer during the melting of solid particle is described. The calculation results are in good agreement with experimental data on melting duration. The effect of applied electric field on melting kinetics is studied. Almost twofold increase of melting time is found in an electric field of strength E = 82 kv/m. In addition a rotation of a solid core inside a melt is observed, which is a manifestation of Quinke effect. A droplet shape evolution during phase transition is described. It is shown that initially elongated particle is almost spherical near the melting point and elongates again with the temperature rise. This shape evolution is explained by non-monotonous change of surface tension and is connected with rotational phase. Thus a possibility is shown to control a melting rate of normal alkanes using electric field.
Thermodynamics of non-Newtonian fluids (drilling mud)
Authors: Beletsky Jа.S. , Shymko T.J. , Beletsky I.J. , Senyushkovych M.V. 
Published: March 2018

Using the method of pressure balance with balance energy forms, calculations are made hidrotermodynamichni mobile hydraulic flow in the well drilling fluids, water-based, which accumulate and transmit energy to other elements. The cases of the flow of liquid upwards (against gravity) and the current flow under gravity down to the bottom hole. The resulting complex equation with specific values ​​that do not depend on the scale of thermodynamics and fluid mechanics processes that occur in the borehole. By combining different similarity criteria can assess the impact of these processes on the performance of any operation in the well during its construction.
The dependences can be used dlyautochnennya procedures governing the calculation of regime and technological parameters of the construction of deep wells.
Argand diagram and oscillator strength of In0,5Tl0,5I crystal
Authors: Kashuba A.I. , Apunevych S.V. , Franiv A.V. , Bovgyra O.V. 
Published: March 2018

The dynamics of the electron subsystem parameters in In0.5Tl0.5I substitutional solid solutions has been studied theoretically using of the pseudopotential method. According to Kramers-Kronig method there have been determined the optical functions of the multilayer In0,5Tl0,5I for the different light polarizations in a broad energy range (0 - 15 eV). The energies of oscillators were defined from the Argand diagrams. The main oscillator settings transitions has been determined.
Electroinduced Diffusion of Lithium Ions into the Structure of Magnesium Fluoride
Authors: Ilnіtskyy R.V. , Budzulyak I.M. , Sichka M.Ja. , Voytkiv S.V. , Gasyuk M.І. , Ostafiychuk B.K. 
Published: March 2018

It has been established that in the process of intercalation/deintercalation of lithium ions into the MgF2-based cathode material, thediffusion coefficient is (1-3)·10-12сm2/s during intercalation and(0,6-3)·10-11сm2/s during the inverse process. It shows the possibility of using MgF2 as a cathode material for a lithium element.
Electrical Instability of CdTe:Si Crystals
Authors: Nykoniuk Ye.S. , Panchuk O.E. , Solodin S.V. , Zakharuk Z.I. , Fochuk P.M. , Kovalets M.O. 
Published: March 2018

Results of Hall effect measurements of cadmium telluride crystals, doped by silicon (dopant concentration in the melt was 1018 - 1019 cm-3), allowed to classify the studied samples and the conditions under which probably the definite crystal and impurity states are realized. We have found the distinction between 3 type of CdTe:Si crystals: (1) low-resistance p-type crystals with shallow acceptors, in which Si impurity is localized mainly in the large inclusions; (2) semi-insulating crystal with deep acceptors and submicron size dopant precipitates that are source/drain for interstitials Sii - shallow donors; and (3) low-resistance crystals in which the n-type conductivity is provided by shallow donors: Sii (and/or SiCd). Therefore the silicon is responsible for n-type conductivity of doped samples, introducing as a donor Siі and provides semi-insulating state by forming deep acceptor complexes (SiCd-VCd2-)- with (Еv + 0.65 eV). Besides, the submicron silica precipitates, that have a tendto"dissolution" at relatively low temperatures, can act aselectricallyactive centers.
Kinetics of Fragmentation During Annealing in Vacuum of Titanium Nanofilms Deposited Onto Non-Metallic Materials
Authors: Naydich Yu.V. , Gab I.I. , Stetsyuk T.V. , Kostyuk B.D. , Shakhnin D.B. 
Published: March 2018

The results are presented of the study of kinetics of fragmentation of titanium nanofilms 100 nm thick deposited onto the surface of samples made from single crystals of Al2O3 (leucosapphire), ZrO2, SiC, and AlN ceramics and annealed in vacuum at temperatures 1300 ¸ 1600 °C with different exposition times at each temperature within 2 - 20 min range.
Magnetoresistance of Bi2Se3 Whiskers at Low Temperatures
Authors: Liakh-Kaguy N.S. , Druzhinin A.A. , Ostrovskii I.P. , Khoverko Yu.N. 
Published: March 2018

Temperature dependencies of Bi2Se3 whiskers’ resistance with Pd doping concentration of 1´1019 cm-3 where measured in temperature range 4.2 - 300 K. At temperature 5.3 K a sharp drop in the whisker resistance was found. The observed effect is likely connected with contribution of two processes such as the electron localization in the whiskers and transition in superconducting state at temperature 5.3 K, which is likely result from Pd complexes.Transversemagnetoresistance in n-type Bi2Se3 whiskers with Pd doping concentration in the vicinity to themetal-insulator transition (MIT) from metal side of the transition were studied in magnetic field 0 -10 T. For the whiskers a resistance minimum was observed at temperature about 25 K that is connected with Kondo effect.
Synthesis, Electrical and Magnetic Properties of Composites Copper Iodide/Magnetite-Polychlorotrifluoroethylene
Authors: Mazurenko R.V. , Abramov М.V. , Makhno S.М. , Gunya G.M. , Gorbik P.P. 
Published: March 2018

The structural, magnetic and electrophysical properties of composites based on nanosized magnetite chemically modified of copper iodide and polychlortrifluoroethylene have been studied at temperatures 298 – 450 K and CuI concentrations of from 0 to 0,58 volume. It has been found the optimal volume content of copper iodide (~ 0.4) in the composites CuI/Fe3O4, when the interfacial interaction shows most intensively and maximum values electrical parameters take place. The value of the coercive force of nanocomposites CuI/Fe3O4 increases with increasing content copper iodide. It was shown that polymer composites containing CuI/Fe3O4, have higher values of real and imaginary components of complex permittivity and conductivity compared with a system that contains only copper iodide.