bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies
Authors: Yang Yibo , Wang Jing , Li Hui , Liu Lihong , Yao Maojin , Xiao Tao 
Published: February 2019

Abstract

Introduction:
SEMA4D and its high affinity receptor Plexin-B1 showed a promising prognosis prediction for carcinoma patients in recent studies, we performed a meta-analysis to evaluate the prognostic role of them in various malignancies.

Methods:
A systematic literature search was performed in PubMed, Embase, Web of Science, and CNKI from inception till July 2017. Eligible studies were identified by different reviewers. Hazard ratios (HRs)/related ratios (RRs) and their corresponding 95% confidence intervals (CIs) were extracted to investigate the relevance between malignancies prognosis and SEMA4D/Plexin-B1.

Results:
Around 2638 patients from 14 studies were included in this meta-analysis. High expression of SEMA4D was significantly associated with overall survival (OS) and disease-free survival/progression-free survival/recurrence-free survival (DFS/PFS/RFS) in tumors (respectively, HRos = 2.05, 95%CI: 1.68–2.50, P < .001; HRdfs/pfs/rfs = 1.59, 95%CI = 1.27–1.98, P < .001). However, the relationship between SEMA4D expression and prognosis of breast cancer patients was failed to find (HR = 0.76, 95%CI = 0.32–1.82, P = .539). Plexin-B1 level showed a significant positive correlation both with OS and DFS of Caucasian breast cancer patients (respectively, HRos = 0.56, 95%CI: 0.39–0.79, P = .001; HRdfs = 0.68, 95%CI = 0.51–0.90, P = .008)

Conclusions:
SEMA4D could be a prospective biomarker for prognostic prediction of various malignancies except breast cancer. For Caucasian breast cancer patients, SEMA4D's high affinity receptor Plexin-B1 showed a significant positive correlation with survival.
Status and factors related to posttraumatic growth in patients with lung cancer
Authors: Peng Xingchen , Su Yonglin , Huang Wenxia , Hu Xiaolin 
Published: February 2019

Abstract
Post-traumatic growth in cancer patients refers to perceived positive changes following cancer diagnosis and treatment. Little is known about the status and factors related to posttraumatic growth among Chinese patients with lung cancer.
To investigate the status and factors of posttraumatic growth among Chinese patients with lung cancer.
A cross-sectional design was adopted in this study. Patients (N = 173) from the oncology unit at one teaching hospital in Sichuan were recruited. Posttraumatic growth, depression, anxiety, and coping style were self-reported by the patients. Multiple linear regression analysis was to examine factors related to posttraumatic growth.
Posttraumatic growth was a common exit in Chinese lung cancer patients. Time since cancer diagnosis, patient depression, and coping strategies are factors that affect the experience of posttraumatic growth.
Reducing depression, providing available support, and improving active coping strategies are areas to facilitate posttraumatic growth.
Is perioperative colloid infusion more effective than crystalloid in preventing postoperative nausea and vomiting?
Authors: Kim Hyun Jung , Choi Seung Ho , Eum Darhae , Kim Seung Hyun 
Published: February 2019

Abstract

Background:
Adequate intravenous fluid replacement is recommended as an effective nonpharmacologic strategy for reducing postoperative nausea and vomiting (PONV), one of the most common and stressful complications of general anesthesia. We aimed to evaluate the effect of hydration, according to the type of fluid, on PONV as previous studies have reported inconsistent results.

Methods:
We performed a systemic review and meta-analysis of randomized controlled trials (RCTs) comparing infusion of colloid with that of crystalloid in terms of PONV incidence and the need for rescue antiemetic therapies for 24 hours after surgery under general anesthesia. The effect of fluid infusion according to the duration of anesthesia was also examined. A literature search was performed, using MEDLINE, Excerpta Medica Database, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus, up to February 2018.

Results:
We included 8 RCTs. Compared with the crystalloid infusion, perioperative colloid infusion did not reduce PONV incidence, with a relative risk of 0.87 (95% confidence interval [CI], 0.60–1.25). However, subgroup analysis by duration of anesthesia showed a statistically significant subgroup effect (P = .04, I

2
= 77.4%), suggesting that the effect of colloid differed from that of crystalloid depending on the duration of anesthesia. In the subgroup that underwent anesthesia for more than 3 hours, in which the patients had mostly undergone abdominal surgeries, colloid infusion significantly reduced the incidence of PONV compared with crystalloid infusion (RR, 0.69; 95% CI, 0.53–0.89). In the subgroup that underwent anesthesia for <3 hours, colloid infusion did not reduce the incidence of PONV compared with crystalloid infusion (RR, 1.32; 95% CI, 0.76–2.27). The requirement for antiemetics was comparable between colloid and crystalloid infusions, with an RR of 0.93 (95% CI, 0.55–1.58).

Conclusion:
Colloid administration had a more preventive effect on PONV than crystalloid administration in patients undergoing abdominal surgery under general anesthesia for more than 3 hours but did not show a preventive effect in patients undergoing anesthesia for <3 hours.
Solitary nasopharynx metastasis from hepatocellular carcinoma after liver transplantation
Authors: Lou Li-Li , Zhang Ying , Huang Xu , Zhang Li-Xia , Ji Hui-Fan , Li Xu , Guo Xiao-Lin 
Published: February 2019

Abstract

Rationale:
Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths worldwide. Nasopharyngeal metastasis of hepatocellular carcinoma is very rare. This is the first report of posttransplantation nasopharyngeal metastasis.

Patient concerns:
A 45-year-old man with a history of hepatitis B related hepatocellular carcinoma (HCC) in the right segment of the liver received an orthotopic liver transplant. Two year after the transplantation, he suffered from severe headache, and head contrast enhanced CT scans did not show clues for brain or skull metastasis. Then he developed hoarseness and dysphagia.

Diagnosis:
The nasopharyngeal cancer was confirmed to be metastatic tumor from liver histologically according to biopsy.

Interventions:
This patient underwent radiotherapy (RT) of the metastatic nasopharyngeal tumor, and there was significant symptomatic relief.

Outcomes:
The patient died 3 months after nasopharyngeal metastasis was diagnosed.

Lessons:
Recurrence of hepatocellular carcinoma with metastasis of nasopharyngeal carcinoma after liver transplantation is rare, but the prognosis is very poor. Close follow-up of patients should be paid attention to prevent the occurrence of such diseases.
Kawasaki disease complicating bilateral facial nerve palsy and giant coronary artery aneurysms
Authors: Yu Xia , Liu Xiaoxia , Wang Yongchun , Lu Na , Wang Mengjiao , Sun Li 
Published: February 2019

Abstract

Rationale:
Kawasaki disease (KD), which is also known as mucocutaneous lymphnode syndrome, is a vasculitic disease and involves multi-system disorder with various clinical manifestations. KD is specific predilection for the coronary arteries and is the most common cause of childhood-acquired heart disease in developed countries. KD is rarely complicated by cranial nerve VII palsy.

Patient concerns:
This report described a 7-month-old infant who suffered from bilateral infranuclear facial nerve palsy (FNP) and multiple coronary artery aneurysms (CAAs) in parallel with KD. The patient had an intermittent fever for 18 days and had a medical history of bilateral conjunctival injection, strawberry tongue, reddened lips, and perianal excoriation. Physical examinations revealed fever (38.5°C), fingertips desquamation of the skin, and left cervical lymphadenopathies.

Diagnosis:
The diagnosis of KD is based on the presence of clinical features of persistent fever (≥5 days) together with polymorphous exanthema, cervical lymphadenopathy, non-purulent conjunctival injection, changes of the lips, oral cavity, and extremities. An echocardiogram has showed a beaded sample dilatation of all coronary arteries, in addition to aneurysms of the middle of the right coronary artery (6.2 mm in diameter; 14.5 Z score), and the left coronary artery (5.4 mm in diameter; 9.4 Z score). The physical examinations revealed incomplete closure of both eyes and bilateral drooping of the mouth, suggesting a bilateral infranuclear FNP.

Interventions:
The patient received intravenous immunoglobulin (IVIG) (2 g/kg) with high-dose aspirin according to the clinical guidelines.

Outcomes:
Her fever finally resolved after 2 days’ IVIG. All inflammatory indexes returned to normal or near-normal levels prior to discharge. However, the echocardiogram remained unchanged and the patient's facial nerve palsies had not recovered.

Lessons:
FNP in KD is uncommon. Yet, it may be a marker of disease progression. One should be aware of the diagnosis of KD when children suffer from high fever, FNP, and even with incomplete clinical features.
High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder
Authors: Lu Yun-Rong , Rao Ying-Bo , Mou Yu-Jian , Chen Yan , Lou Han-Fen , Zhang Yu , Zhang Dan-Xuan , Xie Hai-Yan , Hu Li-Wei , Fang Ping 
Published: February 2019

Abstract
Immune system dysregulation plays a key role in the physiopathology of bipolar disorder (BD) and major depressive disorder (MDD). However, whether interleukins might be biomarkers to distinguish these 2 affective disorders is unclear. Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD. In total, we enrolled 21 MDD patients, 26 BD patients, and 20 healthy controls. We collected a total of 35 samples from BD patients in 3 different phases, depression phase, manic phase, and remission stage, and 27 samples from MDD patients in acute and remission phases. Serum IL-6 and IL-8 levels were assessed with solid phase sandwich ELISA-based quantitative arrays, and CRP levels were determined with an automatic analyzer. Both serum IL-6 and IL-8 levels were elevated in BD patients but not MDD patients. Subgroup analysis indicated elevated serum IL-6 in both the depression and manic phases in BD patients. The serum CRP levels did not change in either BD or MDD patients. However, sex differences in CRP concentrations were observed in healthy controls. Furthermore, there were linear correlations between the CRP levels and Bech-Rafaelsen Mania Rating Scale (BRMS) scores in BD patients. IL-6 and IL-8 levels may serve as biomarkers to differentiate between MDD and BD patients, even when the clinical manifestations are atypical. IL-6 may be used for the differential diagnosis of MDD and depressive episodes in BD.
The effects of aging on the profile of the cervical spine
Authors: Liu Jingpei , Liu Peng , Ma Zikun , Mou Jianhui , Wang Zhaolin , Sun Dong , Cheng Jie , Zhang Dengwei , Xiao Jianlin 
Published: February 2019

Abstract
The study aims to investigate the effects of aging on the cervical spine.
Outpatients in the study were grouped by age. The cervical spine image in the sagittal plane from participants in the supine position was acquired with MRI. Thoracic inlet angle (TIA), T1 slope (T1S), neck tilt (NT), and cervical angle (CC2–7) were measured.
NT and TIA measured 41.84 ± 9.26 and 64.15 ± 10.72 in participants younger than 40, and 53.02 ± 9.52 and 72.09 ± 10.49 in participants older than 40 (P < .01). CC2–7 measured 6.11 ± 9.88 in participants younger than 40, significantly lower compared with participants older than 40, which measured 10.89 ± 11.02 (P = .003). TIS did not differ significantly between the 2 groups (P = .087). No significant difference was found in all measurements between the female and male participants. Age was moderately correlated with NT (r = 0.466, P < .01) and TIA (r = 0.512, P < .01), but weakly correlated with CC2–7 (r = 0.315, P < .01) and TIS (r = 0.210, P = .005). TIA showed a strong correlation with NT (r = 0.748, P < .01) and a moderate correlation with T1S (r = 0.458, P < .01). Lastly, T1S was strongly correlated with CC2–7 (r = 0.701, P < .01).
The result showed that NT, CC2–7, and TIA, but not T1S, increased with age.
The efficacy of the new medical internship management network system
Authors: Xia Oudong , Ye Jiaqi , Lin Anqi , Chen Yating , Guo Wenjie , Fong Tszhei , Qian Ruolan , Luo Peng , Zeng Zhirong 
Published: February 2019

Abstract
With the increasing number of medical students and scattered host hospitals, the traditional clinical internship management system has been falling behind. Thus, we have independently developed a new clinical practice management system based on the browser/server structure.
We aim to evaluate the efficacy of the new medical management system on the quality of the internship and survey the users’ satisfaction.
This study was conducted on the students of Second Clinical Medical College of Southern Medical University, including 672 interns (non-user group) who had not used the system and 315 users (user group). We analyzed the scores of their theoretical knowledge and clinical skills before and after the internship, which served as the quantitative standards for evaluating the efficacy of the system. User satisfaction surveys were also conducted, including by interns, clinical teachers, and teaching administrators.
An analysis of scores showed that the user group had more significant improvement in both clinical knowledge and skills than the non-user group after the internship. Significant improvement was found in the user group, while there was a slight difference in the non-user group. A total of 310 students responded to the satisfaction questionnaires effectively, most of whom agreed with the system's benefits of learning theoretical knowledge (98.1%, n = 304) and clinical skills (93.9%, n = 291). Additionally, 115 clinical teachers and 27 teaching administrators were selected using a random sampling method for the survey. The results showed that 96.3% of the teachers considered the system to be helpful for improving teaching quality, and 92.6% administrators thought it was useful for implementing management. Over 90% of the participants in the 3 user groups reported a strong satisfaction of the system.
With high level of user satisfaction, this system helps to strengthen the management for interns and improves the medical knowledge and skills of interns. Hence, it could be widely used in medical colleges and even in other fields.
Effect of segmental muscle vibration on upper extremity functional ability poststroke
Authors: Annino Giuseppe , Alashram Anas R. , Alghwiri Alia A. , Romagnoli Cristian , Messina Giuseppe , Tancredi Virginia , Padua Elvira , Mercuri Nicola Biagio 
Published: February 2019

Abstract

Background:
Upper extremity functional impairments are common consequences of stroke. Therefore, continuous investigation of effective interventions for upper extremity functions after stroke is a necessity. Segmental muscle vibration (SMV) is one of the interventions that incorporate sensory stimulation to improve motor cortical excitability. The aim of this study was to investigate the influence of 5-minute SMV application along with supervised physical therapy (SPT) on improving activities of daily living and motor recovery on the hemiparetic upper extremity in patients with stroke.

Methods:
A sample of 37 patients poststroke (29 males) was randomly allocated to either SPT control group (n = 18) or SPT and SMV (SPT-SMV) experimental group (n = 19). All patients received 3 sessions per week of SPT for 8 weeks. The SPT-SMV experimental group received SMV at the end of each SPT session. Outcome measures used were Barthel index (BI), modified Ashworth scale, manual muscle testing, and goniometry for range of motion (ROM) assessment.

Results:
Thirty-four patients completed the study. Patients in both groups improved significantly after treatment in BI, elbow ROM, and elbow muscles strength. However, muscle tone in elbow joint of the hemiplegic upper extremity improved significantly after SMV only in the experimental group (SPT-SMV).

Conclusion:
The SPT intervention can improve functional outcomes of upper extremity in people after stroke. However, using SMV may have superior effect on improving muscle tone after stroke.
Body posture and physical activity in children diagnosed with asthma and allergies symptoms
Authors: Brzęk Anna , Knapik Andrzej , Sołtys Jacek , Gallert-Kopyto Weronika , Famuła-Wąż Anna , Plinta Ryszard 
Published: February 2019

Abstract
Asthma and body posture abnormalities in children and young people are major epidemiological problems worldwide. Asthma among children and adolescents, its relations with physical activity (PA) and PA relations with body posture were and are still being investigated.
The aim of this study was to investigate how body posture is shaped in children diagnosed with asthma symptoms and whether body posture is associated with PA. The study involved 192 children. The main group consisted of 90 children diagnosed with asthma and allergies symptoms age 9 to 12 years old (x = 10.75 ± 1.08). The control group included 102 healthy children at the similar age (x = 10.64 ± 1.1). The level of activity has been assessed on the basis of a questionnaire and body posture assessments were done using a plumb line, pediscoliometer, digital inclinometer.
Comparison of percentage of respondents fitting into body posture norms clearly indicates higher value in the group classified as active. In the group of participants diagnosed with asthma, percentage differences of participants with good body posture (without postural defects) were statistically significant. Among healthy children, percentages of the participants were higher in active children than in inactive children.
Body posture is directly related to PA and the lack of activity affects disturbances within posturometric parameters. Prevention of body posture abnormalities is worth promoting in groups of children, also with various diseases including asthma and allergies symptoms.
Emphysema quantification using hybrid versus model-based generations of iterative reconstruction
Authors: Martin Steve P. , Gariani Joanna , Feutry Grégoire , Adler Dan , Karenovics Wolfram , Becker Christoph D. , Montet Xavier 
Published: February 2019

Abstract
To compare 2 incompatible generations of iterative reconstructions from the same raw dataset based on automatic emphysema quantification and noise reduction: a hybrid algorithm called sinogram affirmed iterative reconstruction (SAFIRE) versus a model-based algorithm called advanced modeled iterative reconstruction (ADMIRE).
Raw datasets of 40 non-contrast thoracic computed tomography scanners obtained from a single acquisition on a SOMATOM Definition Flash unit (Siemens Healthcare, Forchheim) were reconstructed with 3 levels of SAFIRE and ADMIRE algorithms resulting in a total of 240 datasets. Emphysema index (EI) and image noise were compared using repeated analysis of variance (ANOVA) analysis with a P value <.05 considered statistically significant.
EI and image noise were stable between both generations of IR when reconstructed with the same level (P ≥0.31 and P ≥0.06, respectively).
SAFIRE and ADMIRE perform equally in terms of emphysema quantification and noise reduction.
Integrating traditional Chinese medicine healthcare into dementia care plan by reducing the need for special nursing care and medical expenses
Authors: Lin Shun-Ku , Lo Pei-Chia , Chen Wang-Chuan , Lai Jung-Nien 
Published: February 2019

Abstract
Reducing the need for advanced nursing care and medical expenses is an essential concern of dementia care. We investigated the impact of traditional Chinese medicine (TCM) on advanced nursing care and medical costs.
We used Longitudinal Health Insurance Database to implement a cohort study of patients with dementia between 1997 and 2012 in Taiwan. Data from the onset of dementia to 1st advanced nursing care for the endotracheal tube, urinal indwelling catheterization, and nasogastric tube were assessed using Cox regression proportional hazards model, and independent t test was used to determine the difference of hospitalization costs and days. We also used ANOVA test to compare the hospital cost, hospital stay, and numbers according to different duration of TCM.
We assessed 9438 new diagnosed patients with dementia without advanced nursing care were categorized into 2 groups: 4094 (43.4%) TCM users, and 5344 (56.6%) non-TCM users. In the TCM groups, 894 (21.8%) patients were declared as advanced nursing care, while 1683 (31.5%) patients were in non-TCM group. Cox proportional hazard regression indicated that using TCM may decrease the need for advanced nursing care (adjusted hazard ratio (aHR) = 0.61, 95% confidence interval [95% CI]: 0.56–0.66) compared to non-TCM. The TCM users have lower hospitalization costs and hospitalization time compared to non-TCM users.
Integrating TCM healthcare into dementia care was found to be associated with a lower need for advanced nursing care, hospitalization costs, and admission time with more benefits from longer durations of TCM use.
Risk of subsequent health disorders among living kidney donors
Authors: Lin Shih-Yi , Lin Cheng-Li , Sung Fung-Chang , Chang Chao-Hsiang , Wu His-Chin , Chen Wen-Chi , Wang I-Kuan , Chen Chao-Jung , Chou An-Kuo , Kao Chia-Hung 
Published: February 2019

Abstract
Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.
We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. From January 1997 to December 2010, 1081 living KDs and 1082 age- and sex-matched non-KDs were eligible. Primary outcomes comprised end-stage renal disease, chronic kidney disease, stroke, cancer, acute myocardial infarction, acute renal failure (ARF), and diabetes.
The adjusted hazard ratios (HRs) for developing ARF, diabetes, hyperlipidemia, hypertension, cancer, end-stage renal disease, acute myocardial infarction, and stroke were similar between the KD and non-KD cohorts (P > .05). Although differences in the adjusted HRs of ARF were nonsignificant, the cumulative incidence rate of ARF 13 years after donation was 7.48 per 1000 person-years in the KD cohort compared with 3.46 in the matched non-KD cohort. The incidence rate ratio for ARF between donors and nondonors significantly increased to 2.16 (95% confidence interval, 1.61–2.71).
Living KDs experienced no significant health disorders following kidney donation but should be alert to the higher incidence rate of ARF.