bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylaxis of chemotherapy‐induced neutropenia and febrile neutropenia with lipegfilgrastim in patients with non‐Hodgkin lymphoma (NADIR study)
Authors: Wolff Thomas , Schulz Holger , Losem Christoph , Reichert Dietmar , Hurtz Hans‐Jürgen , Sandner Reiner , Harde Johanna , Grebhardt Sina , Potthoff Karin , Mueller Udo , Fietz Thomas 
Published: October 2018

AbstractObjectiveThe prospective non‐interventional study (NIS) NADIR was designed to evaluate both effectiveness and safety of prophylactic use of lipegfilgrastim (Lonquex®), a glycopegylated granulocyte colony‐stimulating factor, in cancer patients with different tumor entities undergoing chemotherapy in routine clinical practice. The primary objective was incidence of severe neutropenia, febrile neutropenia (FN), and neutropenia‐associated complications.MethodNADIR was a national, multicenter, prospective NIS.ResultsHere, we present the data on patients with non‐Hodgkin lymphoma (NHL). Final analysis comprised 337 NHL patients having received ≥1 administration of lipegfilgrastim. Primary prophylaxis with lipegfilgrastim was documented in 78.7% of patients with high risk to develop FN. In total, ≥1 severe neutropenia (grade 3/4) was reported in 115 (34.1%) patients and ≥1 event of FN documented in 15 (4.5%) patients. Grade 3/4 infections were reported in 22 (6.5%) patients overall. Most frequently reported adverse events (AEs) related to lipegfilgrastim in total were bone pain (5.4%), leukocytosis (2.1%), back pain (1.8%), platelet count decreased (1.2%), and myalgia (1.2%). Fatal serious AEs were documented in 9 (2.7%) patients; none were attributable to lipegfilgrastim.ConclusionProphylaxis or therapeutic intention with lipegfilgrastim in NHL patients in routine clinical practice showed similar effectiveness and safety as demonstrated in the pivotal trials.
A novel hybrid method for selecting soccer players during the transfer season
Authors: Nasiri Mohammad Mahdi , Ranjbar Mojtaba , Tavana Madjid , Santos Arteaga Francisco J. , Yazdanparast Reza 
Published: October 2018

AbstractThe quality of its players is one of the most significant features determining the failure or success of a sports team. The wide array of factors contributing to the performance of the players together with the inherent financial limitations of the clubs have transformed the selection of players into a complex problem. The current paper presents an integrated approach that combines multiple‐criteria decision‐making analysis and mathematical programming to support the decision maker through the building process of a soccer team. First, the fuzzy analytic network process is applied to evaluate the significance of the different performance criteria for each position in the field. The score attained by the different players in each potential position is computed using PROMETHEE II. A biobjective integer programming model has been designed to evaluate the transfer status of the players. Finally, data envelopment analysis is used to identify the most efficient Pareto solution determining the status of each player. In order to demonstrate the applicability of the proposed approach, the position in the field and transfer status of 60 players being considered by a real soccer team have been determined.
Effect of Laves phase on the toughness of P92 weld metals
Authors: Wang Xue , Du Chengchao , Liu Hong , Liu Hongwei 
Published: October 2018

AbstractIn this investigation, Laves phase was found to gradually precipitate from the tempered martensitic matrix of the two P92 weld metals (WMs) during the aging treatment. The particle size of Laves phase in the two WMs was ranged from 0.18 to 0.24 μm and was larger than the M23C6 particle size (ranged from 0.09 to 0.13 μm). The dislocation density of the two WMs was stable during aging. The hardness of the two WMs was stable during aging treatment, as the loss of solid solution strengthening was continuously compensated by the precipitation strengthening of Laves phase. The impact toughness of the two WMs declined gradually as the extending of aging time. The crack initiation zone and shear lip zone of the fracture surface were ductile fracture mode which consumed more fracture energy during impacting. The generation of Laves phase narrowed the crack initiation zone and shear lip zone and contributed to the decline of ductile fracture area percentage of aged WMs. The smaller ductile fracture area percentage contributed to the toughness reduction of aged WMs.
Improved survival following splenectomy combined with curative treatments for hepatocellular carcinoma in Child B patients: A propensity score matching study
Authors: Pei Youliang , Zhang Zhanguo , Mba'nbo‐koumpa Abdoul‐aziz , Chen Xiaoping , Zhang Wanguang 
Published: October 2018

AimsTo explore the benefits of curative treatments (liver resection or local ablation) combined with splenectomy for patients with hepatocellular carcinoma (HCC) and Child grade B liver function.MethodsWe reviewed 245 patients with Child grade B liver function who underwent treatment with curative intent for HCC. Among these patients, 116 patients underwent curative treatment combined with splenectomy (the splenectomy group); the other 129 patients only underwent curative treatment (the non‐splenectomy group). A one‐to‐one matching produced 95 paired patients, perioperative and oncological outcomes were compared, and liver function changes were reassessed 1 year later.ResultsThe perioperative liver failure rates were 7.4% and 6.3% (P = 1.000) and the 90‐day mortality was 4.2% and 6.3% (P = 0.747) in the splenectomy group and non‐splenectomy group, respectively. The 1‐, 3‐, and 5‐year overall survival rates were remarkably greater in the splenectomy group than in the non‐splenectomy group (92.6% vs. 79.8%, 53.4% vs. 34.7%, and 19.9% vs. 11.0%, respectively; P = 0.004). In the univariate and multivariate analyses, splenectomy was identified as a protective factor for long‐term survival. The proportion of patients whose liver function improved to Child A 1 year after surgery was also higher in the splenectomy group than in the non‐splenectomy group (95.4% vs. 83.3%; P = 0.048).ConclusionsCompared with non‐splenectomy, curative treatments combined with splenectomy for patients with HCC and Child B grade liver function showed no different perioperative outcomes but achieved significant survival benefit. Splenectomy is a beneficial factor for patients with HCC and Child B liver function; liver function improved significantly 1 year after splenectomy.
Interdisciplinarity for sale: Logics of knowledge, labour markets and consumerism
Authors: Pizarro Milian Roger , Missaghian Rod 
Published: October 2018

AbstractInterdisciplinary programmes have proliferated across post‐secondary education in recent decades. Despite this, little attention has been paid to the manner in which interdisciplinary programmes promote themselves to external constituents. To study this process, we conduct a content analysis of the online self‐descriptions of 203 credential‐granting interdisciplinary programmes across the Canadian university sector. We find that these entities embrace contrasting logics of superior knowledge, labour market outcomes and customisation. We interpret these findings through the lens of contemporary theorising within organisation studies, noting that their ambidexterity bodes well for their continued existence within the sector.
Supplement overview: what the Healthy Communities Study is telling us about childhood obesity prevention in U.S. communities
Authors: Kumanyika S. K. 
Published: October 2018

SummaryThe Healthy Communities Study (HCS), conducted between 2010 and 2016, tells a real‐world story of how childhood obesity prevention efforts have unfolded in 130 U.S. communities. The study documented nearly 10,000 current and past community policies and programs (CPPs) and assessed dietary and physical activity behaviors, weight, height, and waist circumference of more than 5,000, 4‐ to 15‐year‐old children. The articles in this HCS supplement describe the variables created to characterize the CPPs, CPP relationships with children's behavioral and weight status, other analyses of interest, and recruitment challenges. Findings suggest that many of the strategies being implemented work as intended to improve children's behaviors and weight status. However, of concern, findings also indicate lesser reach to children in demographic groups at highest risk of obesity. Overall, the HCS insights can guide the next phase of efforts to strengthen existing CPPs and motivate other, novel approaches to combating childhood obesity.
Optimal carbon reduction level and ordering quantity under financial constraints
Authors: Cao Kaiying , Xu Bing , He Yi , Xu Qingyun 
Published: October 2018

AbstractCarbon tax policy is widely adopted by many countries to curb carbon emissions. In the context of carbon tax policy, firms have more incentive to improve carbon reduction levels by reducing their carbon tax costs. However, firms need to bear carbon reduction costs that may cause shortage of capital. Thus, firms may face problems of financial constraints, which may demotivate firms to produce greener products. To address the decision‐making challenges of firms in the contexts of carbon tax policy and financial constraints, we consider a supply chain with a manufacturer who produces green products and a retailer who sells these products. Our study develops five models to investigate the two firms’ optimal wholesale price, carbon reduction level and ordering quantity, according to the manufacturer and retailer with or without financial constraints. Our goal in this study is to explore how carbon tax policy and banks’ interest rates affect the profits of the two firms, supply chain and consumer surplus. Certain managerial insights are obtained as follows. We demonstrate that carbon tax policy and banks’ interest rates demotivate the manufacturer to produce greener products and demotivate the retailer to order more products. If the interest rate to the manufacturer (retailer) is relatively low, then the manufacturer with financial constraint benefits (harms) the consumers compared with the retailer with financial constraint. Importantly, our analysis suggests that carbon tax policy harms the firms but benefits consumers, and the government in some conditions should reduce unit carbon tax.
Notes on the Underground: Monetary Policy in Resource‐Rich Economies
Authors: FERRERO ANDREA , SENECA MARTIN 
Published: October 2018

AbstractThe central bank of a commodity‐exporting small open economy faces the traditional trade‐off between domestic inflation and output gap. The commodity sector introduces a terms‐of‐trade inefficiency that gives rise to an endogenous cost‐push shock, changes the target level for output, reduces the slope of the Phillips curve, and increases the importance of stabilizing the output gap. Optimal monetary policy calls for a reduction of the interest rate following a drop in the oil price. In contrast, a central bank with a mandate to stabilize consumer price inflation raises interest rates to limit the inflationary impact of an exchange rate depreciation.
Public Funding for Science and the Value of Corporate R&D Projects; Evidence from Project Initiation and Termination Decisions in Cell Therapy
Authors: Huang Hsini , Jong Simcha 
Published: October 2018

AbstractHow do firms decide which R&D projects to pursue and which ones to cast aside? We use a real options approach to advance our understanding of how firms manage uncertainties in R&D project management, in particular uncertainties linked to the external scientific environment. Our findings highlight how these uncertainties have an impact on the initiation and discontinuation of R&D projects. We examine these effects in the context of shifts in US science policy in the cell therapy field, using a dataset on 570 R&D projects in the global cell therapy sector, initiated over the period 1986–2011. We find decreased R&D project initiation rates and higher discontinuation rates for projects initiated by US firms in the aftermath of policy shifts that increased uncertainties about public funding support for US cell therapy research. We also highlight how this effect was reversed as the US public funding outlook for such research recovered.
How does the Household Labour Supply Respond to the Unemployment of the Household Head?
Authors: Cardona‐Sosa Lina , Flórez Luz Adriana , Morales Leonardo Fabio ,   Banco de la República
Published: October 2018

AbstractIn this paper, we explore one of the oldest labour market phenomena documented in the literature: the added worker effect. This refers to the labour supply response of secondary earners of the household to the main earner's job losses. Using longitudinal data for Colombia, we find that when the head of the household becomes unemployed, the labour supply of the female partner increases between 9 and 20 percentage points. Such response appears during the first 6 months of the unemployment spell of the household head. In addition, within 1 year of the unemployment shock, household members under college age were more likely to enter the labour market and less likely to be in tertiary education.
Chronic kidney disease is independently associated with increased mortality in patients with nonalcoholic fatty liver disease
Authors: Paik James , Golabi Pegah , Younoszai Zahra , Mishra Alita , Trimble Gregory , Younossi Zobair M. 
Published: October 2018

AbstractBackground & AimsNonalcoholic fatty liver disease and chronic kidney disease share similar pathophysiologic features. Our aim was to assess the association between different stages of chronic kidney disease and mortality in patients with nonalcoholic fatty liver disease.MethodsThird National Health and Nutrition Examination Survey‐linked mortality files were utilized. Nonalcoholic fatty liver disease was diagnosed by hepatic ultrasound and chronic kidney disease was defined according to the Kidney Disease Improving Global outcomes guideline. Multivariable Cox proportional hazard model was used to assess the effect of chronic kidney disease on overall and cardiovascular mortality.ResultsTotal cohort included 11 695 adult participants; mean age 43.3 years, 48.4% male, 76.4% white, 18.6% had nonalcoholic fatty liver disease and 9.3% had chronic kidney disease. 5.6% had diabetes, 21.3% had hypertension, 4.3% had cardiovascular disease. Compared to subjects without chronic kidney disease or nonalcoholic fatty liver disease, nonalcoholic fatty liver disease patients with chronic kidney disease were more likely to be older, had less income, and higher prevalence of comorbidities (all P < 0.001). Prevalence of chronic kidney disease among nonalcoholic fatty liver disease cohort was 11.31%. Compared to non‐nonalcoholic fatty liver disease group, patients with nonalcoholic fatty liver disease had higher rates of stage 1, 2 and 3a chronic kidney disease, but similar rates for stage 3b, 4 and 5. Mortality rate was 18.5% in 17 years. Among nonalcoholic fatty liver disease cohort, the presence of chronic kidney disease stages 2‐3a (HR = 2.31, 95% CI: 1.70‐3.15) and stages 3b‐5 (HR = 4.83, 95% CI: 2.40‐9.71) were independently associated with increased overall mortality.ConclusionsAmong patients with nonalcoholic fatty liver disease, moderate to advanced stages of chronic kidney disease are associated with overall mortality. Identification of chronic kidney disease in nonalcoholic fatty liver disease has important prognostic implications.
Longitudinal analysis of risk of non‐alcoholic fatty liver disease in adulthood
Authors: Cuthbertson Daniel J. , Brown Emily , Koskinen Juha , Magnussen Costan G. , Hutri‐Kähönen Nina , Sabin Matthew , Tossavainen Päivi , Jokinen Eero , Laitinen Tomi , Viikari Jorma , Raitakari Olli T. , Juonala Markus 
Published: October 2018

AbstractBackground & AimsWe aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non‐alcoholic fatty liver disease.MethodsData from 2020 participants aged 3‐18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life‐course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non‐alcoholic fatty liver disease.ResultsThe risk for adult non‐alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non‐alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non‐obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight‐fold to 10‐fold increased risk (P < 0.001).ConclusionsChildhood overweight/obesity, not metabolic health, is associated with increased risk for adult non‐alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.
Factors associated with catch‐up growth in early infancy in rural Pakistan: A longitudinal analysis of the women's work and nutrition study
Authors: Pradeilles Rebecca , Norris Tom , Ferguson Elaine , Gazdar Haris , Mazhar Sidra , Bux Mallah Hussain , Budhani Azmat , Mehmood Rashid , Aslam Saba , Dangour Alan D. , Allen Elizabeth 
Published: October 2018

AbstractThe adverse health impacts of early infant stunting can be partially ameliorated by early catch‐up growth. Few studies have examined predictors of and barriers to catch‐up growth to identify intervention points for improving linear growth during infancy. This study aimed to estimate the prevalence of, and factors associated with, catch‐up growth among infants in Pakistan. A longitudinal study of mother–infant dyads (n = 1,161) was conducted in rural Sindh province, with enrolment between December 2015 and February 2016 (infants aged 0.5–3 months), and follow‐up (n = 1035) between November 2016 and January 2017 (infants aged 9–15 months). The outcome was catch‐up growth (change in conditional length‐for‐age z‐scores >0.67 between baseline and endline). Associated factors were examined using multivariable logistic regression analyses. The prevalence of stunting was 45.3% at baseline and 60.7% at follow‐up. 22.8% of infants exhibited catch‐up growth over this period. Factors positively associated with catch‐up growth included maternal height (odds ratio (OR) = 1.08 [1.05–1.11]), household wealth (OR = 3.61 [1.90–6.84]), maternal (OR = 2.43 [1.30–4.56]) or paternal (OR = 1.46 [1.05–2.03]) education, and households with two or more adult females (OR = 1.91 [1.26–2.88]). Factors negatively associated with catch‐up growth were two (OR = 0.64 [0.45–0.89]) or three or more (OR = 0.44 [0.29–0.66]) preschool children in the household and the infant being currently breastfed (OR = 0.59 [0.41–0.88]). Catch‐up growth was exhibited among approximately a quarter of infants despite living in challenging environments associated with extremely high rates of early infant stunting. Several modifiable factors were identified that might represent suitable programme intervention points to off‐set early infant stunting in rural Pakistan.
Effects of opaque, weighted bottles on maternal sensitivity and infant intake
Authors: Ventura Alison K. , Hernandez Alexandra 
Published: October 2018

AbstractCaregivers' abilities to assess how much is in the bottle may lead to encouragement of infant bottle emptying and overfeeding. The present study assessed whether use of opaque, weighted bottles (as compared with conventional, clear bottles) improves feeding outcomes. Mothers with infants <32 weeks of age (n = 76) were assessed on two separate days. Mothers fed their infants from an opaque, weighted bottle on 1 day and a clear bottle on the other; conditions were counterbalanced. Blinded raters certified in the Nursing Child Assessment Feeding Scale scored all videos to determine maternal sensitivity. Infant intake was assessed by weighing the bottle before and after each feeding, and feeding outcomes included infant intake (mL), intake per kilogram body weight (mL/kg), meal duration (min), and feed rate (mL/min). Mothers exhibited significantly greater sensitivity (p = 0.041), fed their infants fewer millilitres per kilogram body weight (p = 0.049), and fed their infants at a significantly slower rate (p = 0.009) when using opaque compared with clear bottles. Infant clarity of cues was a significant moderator of effects of bottle type on intake per kilogram body weight (p = 0.028): Infants who exhibited greater clarity of cues were fed less during the opaque versus clear conditions whereas infants who exhibited poorer clarity of cues were fed similar amounts during both conditions. Effects of bottle type were not moderated by bottle contents (expressed breast milk vs. formula). In sum, promotion of opaque, weighted bottles for infant feeding may be a pragmatic approach to improve the quality and outcome of bottle‐feeding interactions.
A case of infarction of the region from the declive to the tuber in the cerebellar vermis
Authors: Ogawa Katsuhiko , Suzuki Yutaka , Akimoto Takayoshi , Kamei Satoshi 
Published: October 2018

AbstractWe report a rare case of infarction limited in the region from the declive to the tuber of the posterior lobe in the cerebellar vermis. A 47‐year‐old woman complained of dizziness with acute onset. Mild incoordination of the left upper extremity and mild truncal and gait ataxia was noted. Brain magnetic resonance imaging showed an infarct of the region from the declive to the tuber on the left side. In the posterior lobe, the region from the declive to the tuber is associated with coordination of the hands. The dorsal spinocerebellar tract and the ventral spinocerebellar tract convey unconsciousness proprioceptive signals from the trunk and leg and project to the anterior and posterior lobes in the cerebellar vermis. Symptoms in our patient indicated that the lesion of this region was related to the impairment of these two tracts and incidence of incoordination of the lateral upper extremity.
Prolonged sensory impairment in the perineal region after painless delivery through lumbar epidural anesthesia
Authors: Uemura Maiko T , Mezaki Takahiro , Shibasaki Hiroshi , Takahashi Ryosuke 
Published: October 2018

AbstractIn the painless delivery, the neuronal injury caused by regional anesthesia sometimes causes diagnostic difficulty because of the common findings with lumbosacral injury due to vaginal delivery. We herein report a 36‐year‐old woman presenting with long‐standing cauda equina syndrome due to neurotoxicity of regional anesthetic. Neurological examination revealed the almost symmetrical, heterogeneous sensory deficit mainly in the perineal region, hypoactive quadriceps femoris reflex, decreased anal sphincter reflex, and dermographia. The correct diagnosis is important to support the quality of life of patients.