bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antenatal diagnosis of isolated infracardiac infradiaphragmatic total anomalous venous connection – Pictorial essay and discussion
Authors: Nandhini Usha , Atkinson Monique , Krishna Mani Ram , Alahakoon Thushari Indika 
Published: November 2018

AbstractIntroductionAntenatal diagnosis of isolated infracardiac total anomalous pulmonary venous connection (TAPVC) is rare. Making the diagnosis antenatally is critical as delayed management could result in neonatal deterioration and poor outcome after surgery.MethodA multipara at 29 weeks of gestation was referred to our tertiary unit for ultrasound review. The fetal growth and biophysical profile were normal. A fetal echocardiogram revealed normal cardiac position with atrioventricular and ventriculoarterial concordance. There was a mild discrepancy in size of the right and left chambers of the heart. A connection between the pulmonary veins and the left atrium could not be established. A pulmonary venous confluence was noted posterior to the left atrium, from which a descending vertical vein emerged traversing the diaphragm and draining into the left portal vein into the liver.ResultsA diagnosis of infracardiac infradiaphragmatic total anomalous pulmonary venous connection was made. The pregnancy was delivered at 39 weeks by lower segment caesarean section. The antenatal findings were confirmed by postnatal echocardiogram. Successful sutureless repair of the pulmonary veins was performed.ConclusionIsolated infracardiac total anomalous pulmonary venous connection can be diagnosed antenatally. This ensures early postnatal evaluation and successful repair.
Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED)
Authors: Sabourin Katherine R. , Reynolds Ann , Schendel Diana , Rosenberg Steven , Croen Lisa A. , Pinto‐Martin Jennifer A. , Schieve Laura A. , Newschaffer Craig , Lee Li‐Ching , DiGuiseppi Carolyn 
Published: November 2018

Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of childhood infections. The Study to Explore Early Development (SEED) is a multisite case‐control study of children aged 30–69 months, born in 2003–2006. Cases are children previously diagnosed and newly identified with ASD enrolled from education and clinical settings. Children with a previously diagnosed non‐ASD developmental condition were included in the developmental delay/disorder (DD) control group. The population (POP) control group included children randomly sampled from birth certificates. Clinical illness from infection during the first 28 days (“neonatal,” from medical records) and first three years of life (caregiver report) in cases was compared to DD and POP controls; and between cases with and without regression. Children with ASD had greater odds of neonatal (OR = 1.8; 95%CI: 1.1, 2.9) and early childhood infection (OR = 1.7; 95%CI: 1.5, 1.9) compared to POP children, and greater odds of neonatal infection (OR = 1.5; 95%CI: 1.1, 2.0) compared to DD children. Cases with regression had 1.6 times the odds (95%CI: 1.1, 2.3) of caregiver‐reported infection during the first year of life compared to cases without regression, but neonatal infection risk and overall early childhood infection risk did not differ. Our results support the hypothesis that children with ASD are more likely to have infection early in life compared to the general population and to children with other developmental conditions. Future studies should examine the contributions of different causes, timing, frequency, and severity of infection to ASD risk. Autism Research 2019, 12: 136–146. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryWe looked at infections during early childhood in relation to autism spectrum disorder (ASD). We found that children with ASD were more likely to have an infection in the first 28 days of life and before age three compared to children with typical development. Children with ASD were also more likely than children with other developmental delays or disorders to have an infection in the first 28 days of life.
Social difficulties in youth with autism with and without anxiety and ADHD symptoms
Authors: McVey Alana J. , Schiltz Hillary K. , Haendel Angela D. , Dolan Bridget K. , Willar Kirsten S. , Pleiss Sheryl S. , Karst Jeffrey S. , Carlson Mary , Krueger Wendy , Murphy Christina C. , Casnar Christina L. , Yund Brianna , Van Hecke Amy Vaughan 
Published: November 2018

Social difficulties inherent to autism spectrum disorder are often linked with co‐occurring symptoms of anxiety and attention deficit hyperactivity disorder (ADHD). The present study sought to examine the relation between such co‐occurring symptoms and social challenges. Parents of adolescents with autism (N = 113) reported upon social challenges via the social responsiveness scale (SRS) and anxiety and ADHD symptomatology via the Child Behavior Checklist. Results revealed differences in SRS scores across co‐occurring symptom subgroups (Anxiety, ADHD, Both, Neither)—namely, adolescents with autism and anxiety as well as those with autism, anxiety, and ADHD showed greater scores on the SRS than the other groups. Implications for research and clinical practice are discussed and recommendations are offered. Autism Research 2018, 11: 1679–1689. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryAnxiety and attention deficit hyperactivity disorder (ADHD) symptoms are related to greater social challenges for adolescents with autism spectrum disorder. The present study found that autism with anxiety and autism with anxiety and ADHD, was related to greater social difficulties than autism alone. Findings provide further support for the intertwined nature of anxiety and ADHD symptoms in autism. What this may mean for research and clinical practice is considered and recommendations are suggested.
RNA‐dependent chaperone (chaperna) as an engineered pro‐region for the folding of recombinant microbial transglutaminase
Authors: Lee Jinhee , Son Ahyun , Kim Paul , Kwon Soon Bin , Yu Ji Eun , Han Gyoonhee , Seong Baik L. 
Published: November 2018

AbstractTransglutaminase (TGase) induces the cross‐linking of proteins by catalyzing an acyl transfer reaction. TGase is a zymogen, activated by the removal of its pro‐region. Because the pro‐region is crucial for folding and inhibition of the TGase activity, the recombinant expression of the mature TGase (mTGase) without the pro‐region, usually results in inactive inclusion bodies or low protein yield. Here, Streptomyces netropsis TGase was fused with Escherichia coli lysyl‐tRNA synthetase (LysRS), as a module with chaperoning activity in an RNA dependent manner (chaperna). The TGase activity from purified fusion protein induced via the removal of LysRS by tev protease in vitro. Moreover, active mTGase was produced in E. coli via an intracellular cleavage system, wherein LysRS‐mTGase was cleaved by the coexpressed tev protease in vivo. The results suggest that LysRS essentially mimics pro‐region, which exerts a dual function—folding of TGase into active conformation and keeping it as dormant state—in an RNA‐dependent manner. Thus, trans‐acting RNAs, prompt the cis‐acting chaperone function of LysRS, while being mechanistically similar to the intramolecular chaperone function of the pro‐region. These results could be implemented and extended for the folding of “difficult‐to‐express” recombinant proteins, by harnessing the chaperna function.
Characterizing modes of action and interaction for multicomponent osmolyte solutions on Jurkat cells
Authors: Pi Chia‐Hsing , Yu Guanglin , Dosa Peter I. , Hubel Allison 
Published: November 2018

AbstractThis study examined the post‐thaw recovery of Jurkat cells cryopreserved in three combinations of five osmolytes including trehalose, sucrose, glycerol, mannitol, and creatine. Cellular response was characterized using low‐temperature Raman spectroscopy, and variation of post‐thaw recovery was analyzed using statistical modeling. Combinations of osmolytes displayed distinct trends of post‐thaw recovery, and a nonlinear relationship between compositions and post‐thaw recovery was observed, suggesting interactions not only between different solutes but also between solutes and cells. The post‐thaw recovery for optimized cryoprotectants in different combinations of osmolytes at a cooling rate of 1°C/min was comparable to that measured with 10% dimethyl sulfoxide. Statistical modeling was used to understand the importance of individual osmolytes as well as interactions between osmolytes on post‐thaw recovery. Both higher concentrations of glycerol and certain interactions between sugars and glycerol were found to typically increase the post‐thaw recovery. Raman images showed the influence of osmolytes and combinations of osmolytes on ice crystal shape, which reflected the interactions between osmolytes and water. Differences in the composition also influenced the presence or absence of intracellular ice formation, which could also be detected by Raman. These studies help us understand the modes of action for cryoprotective agents in these osmolyte solutions.
Review of advanced physical and data‐driven models for dynamic bioprocess simulation: Case study of algae–bacteria consortium wastewater treatment
Authors: Del Rio‐Chanona Ehecatl Antonio , Cong Xiaoyan , Bradford Eric , Zhang Dongda , Jing Keju 
Published: November 2018

AbstractMicroorganism production and remediation processes are of critical importance to the next generation of sustainable industries. Undertaking mathematical treatment of dynamic biosystems operating at any spatial or temporal scale is essential to guarantee their performance and safety. However, constructing physical models remains a challenge due to the extreme complexity of process biological mechanisms. Data‐driven models also encounter severe limitations because datasets from large‐scale bioprocesses are often scarce without complete information and on a restricted operational space. To fill this gap, the current research compares the performance of advanced physical and data‐driven models for dynamic bioprocess simulations subject to incomplete and scarce datasets, which to the best of our knowledge has never been addressed before. In specific, kinetic models were constructed by integrating different classic models, and state‐of‐the‐art hyperparameter selection frameworks were developed to design artificial neural networks and Gaussian process regression models. An algae–bacteria consortium wastewater treatment process was selected to test the accuracy of these modeling strategies, as it is one of the most sophisticated biosystems due to the intricate mutualistic and competitive interactions. Based on the current results and available data, a heuristic model selection procedure is provided. This study paves the way to facilitate future bioprocess modeling.
Limbic encephalitis: Experience of a moroccan center
Authors: Toudou‐Daouda Moussa , Filali‐Adib Ahmed , Slassi Aicha , Belahsen Mohammed‐Faouzi , Souirti Zouhayr 
Published: November 2018

AbstractObjectivesHistologically defined as an inflammation—degeneration of limbic structures, limbic encephalitis (LE) is a rare disease and often difficult to diagnose particularly in institutions with limited access to laboratory tests such as antineuronal antibodies or HSV‐PCR, and functional imaging. We aimed to describe the demographic, clinical, paraclinical, and etiological features of LE, as well as its medium‐term prognosis in Moroccan patients.Materials and MethodsWe collected retrospectively all patients diagnosed with LE in the Department of Neurology of the University Hospital Hassan II of Fez (Morocco) between September 2008 and December 2016. We analyzed their demographic features, clinical manifestations, magnetic resonance imaging and laboratory findings, etiologies, and medium‐term prognoses.ResultsWe included 22 men and 9 women aged 14–76 years (mean age: 45.8 years). In 64.5% of cases, the onset of symptoms was acute. The clinical manifestations included generalized status epilepticus (16.1%), confusional syndrome (29%), epileptic seizures (38.7%), psychiatric disorders (48.4%), and memory disorders (45.2%). The nonlimbic symptoms were nuchal stiffness (22.6%), headaches (9.7%), fever (61.3%), vesicular rash (3.2%), and language disorders (6.5%). The different etiologies found were herpes simplex virus (6.5%), syphilis (16.1%), tuberculosis (3.2%), varicella (3.2%), paraneoplastic autoimmune LE (22.6%), anti‐NMDA‐R LE (6.5%), and sarcoidosis (3.2%). We found 12 cases (38.7%) of LE without definite etiology and with an incomplete diagnostic workup. The medium‐term clinical course includes a complete remission in 45.2% of cases and partial remission in 45.1% of cases. The different sequelae were temporal lobe epilepsy (9.7%), anterograde amnesia (16.1%), and severe cognitive impairment (19.4%). The mortality rate was 9.7% (3 patients).ConclusionOur study shows a wide diversity of etiologies of LE in Morocco with essentially an acute mode of onset of symptoms.
Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer
Authors: Feng Lanyun , Gu Shihui , Wang Peng , Chen Hao , Chen Zhen , Meng Zhiqiang , Liu Luming 
Published: November 2018

AbstractPurposeTo identify the pretreatment values of bilirubin and albumin and other serum biomarkers in predicting the prognosis for advanced pancreatic cancer.MethodsA total of 201 consecutive patients pathologically diagnosed as advanced pancreatic cancer were retrospectively reviewed. Tumor location, TNM classification, the level of baseline total bilirubin (TBIT), direct bilirubin (DBIT), albumin (ALB), globulin (GLOB), total protein (TP), ALB to GLOB ratio (AGR), CA19‐9, CA242, and CA50 were collected. The values of CA19‐9, CA242, and CA50 were divided into two groups according to the upper limit value which were 1000 U/mL, 150 IU/mL, and 500 IU/mL, respectively. The values of TBIL, DBIL, IBIL, ALB, GLOB, TP, ALB, and GLOB were divided into low and high groups according to the median. To investigate if the median was an effective discriminator in dividing these markers, the patients were divided into a test set (n = 100) and a validation set (n = 101). Kaplan‐Meier (K‐M) survival analysis and Cox regression analysis were performed to explore the potential relationship between them and overall survival (OS).ResultsA K‐M survival analysis revealed that the investigated markers in test set, including TBIL, DBIL, IBIL, ALB, GLOB, TP, ALB, and GLOB, were not associated with the OS. The findings from the validation set were consistent with those in the test set. Factors with P value smaller than 0.1 in the univariate analysis along with the tumor location, CA19‐9, CA242, CA50, were entered into the multivariate analysis. A Cox regression analysis suggested that the cancerization at head of pancreas (P = 0.01) and a high level of CA19‐9 (P = 0.02) were independent prognostic indicators for poor OS of pancreatic cancer.ConclusionsBaseline bilirubin and serum proteins were not associated with the prognosis of advanced pancreatic cancer. Tumor location and level of CA19‐9 may serve as significant indicators for poor prognosis in those patients.
Atypical Clinical Presentation of Pemphigus and Its Management: A Case Report
Authors: Neely Anthony L. , Choksi Karishma , Othman Abdullah , Patel Krupa , Zhou Zheng , Kinaia Bassam 
Published: November 2018

IntroductionMany mucocutaneous conditions affect the skin and oral cavity. Common conditions include lichen planus, pemphigus, and pemphigoid. This case report shows an atypical presentation of a mucocutaneous condition wherein histopathology was required for definitive diagnosis and treatment.Case PresentationA 51‐year‐old African American male self‐reported to a private periodontal practice with a chief complaint of sporadic painful oral lesions of about 2 months duration. The patient also reported painful throat lesions. He had been previously treated for a sore throat followed by unspecified inflammation of the epiglottis. Clinical examination revealed diffuse bilateral eye redness, numerous intraoral ulcerations on soft and hard palate and floor of the mouth with trouble swallowing. Oral and ocular presentation suggested a differential diagnosis of cicatricial pemphigoid. Pemphigoid and lichen planus were also considered. Ophthalmologic exam revealed only allergies and no other abnormality. Soft tissue biopsies showed intraepithelial separation between the spinous layer and basement membrane. Direct and indirect immunofluorescence showed strong immunoglobulin G and moderate C3 reactivity confirming a diagnosis of pemphigus vulgaris (PV). A rheumatologist initially treated the patient with a daily combination regimen of methylprednisolone and mycophenolate mofetil. Lesions improved after a few weeks on the regimen. Reduction of medications resulted in return of oral and throat lesions. Resumption of the regimen resulted in lesion remission. Azathioprine replaced the mycophenolate mofetil, and then was gradually stopped after methylprednisolone cessation. Lesions have not reappeared for 1 year.ConclusionThis case illustrates that early diagnosis of mucocutaneous lesions leads to proper treatment and possible remission.
Usefulness of longitudinal reconstructed optical coherence tomography images for predicting the need for the reverse wire technique during coronary bifurcation interventions
Authors: Watanabe Makoto , Okura Hiroyuki , Okamura Akihiko , Iwai Saki , Keshi Ayaka , Kamon Daisuke , Isojima Takuya , Ueda Tomoya , Soeda Tsunenari , Saito Yoshihiko 
Published: November 2018

AbstractObjectivesThe aim is to investigate the usefulness of longitudinal reconstructed optical coherence tomography (OCT) images in selecting the reverse wire (RW) technique for inserting a guidewire into a side branch (SB).BackgroundIt is sometimes necessary to protect the SB with a guidewire to prevent SB complications in PCI for bifurcation lesions. The RW is a novel method for guidewire insertion into an extremely angulated SB when the standard antegrade wire (AW) approach is difficult.MethodsThis retrospective study included 46 consecutive patients who underwent OCT‐guided PCI in bifurcation lesions with significant SB stenosis. Patients were divided into two groups: 36 patients with successful guidewire crossing using the AW (AW group) and 10 patients with unsuccessful AW but successful RW guidewire crossing (RW group). SB angle and branch point (BP) slope, defined as the angle between the line connecting the proximal and distal BPs and the vertical, were measured using longitudinal reconstructed OCT images.ResultsThe RW group had a significantly larger SB angle and higher BP slope than the AW group (108.7 ± 11.4° vs. 76.2 ± 14.9°; P < 0.0001, 128.7 ± 31.6° vs. 82.9 ± 33.6°; P = 0.0004, respectively). Receiver operating characteristic curve analysis indicated that SB angle ≥ 100° and BP slope ≥ 120° are optimal cutoff values for predicting the need for RW (area under the curve 0.97, sensitivity 90.0%, specificity 91.7%; area under the curve 0.83, sensitivity 80.0%, specificity 86.1%, respectively).ConclusionsLongitudinal reconstructed OCT is useful for selecting the wiring technique for bifurcation lesions.
Engineering UiO‐66 Metal Organic Framework for Heterogeneous Catalysis
Authors: Dhakshinamoorthy Amarajothi , Santiago‐Portillo Andrea , Asiri Abdullah M. , Garcia Hermenegildo 
Published: November 2018

AbstractMetal organic frameworks (MOFs) are currently attracting considerable attention as heterogeneous catalysts at moderate temperatures, mainly for liquid‐phase reactions. Since structural stability is one of the major concerns for the use of MOFs in catalysis, particularly considering that frequently some of the reported MOF materials are very unstable, the interest in this area has been focused on those MOFs exhibiting the highest structural robustness, UiO‐66 being among the most widely used. Two introductory sections deal with the synthesis, structure and main properties of UiO‐66, including its remarkable thermal (up to 350 °C) and chemical (aqueous solution in a wide pH range) stability. The main body of the review summarizes those examples of using UiO‐66 in catalysis grouped according to the nature of the active sites, starting with the use of UiO‐66 as Lewis acids. In this section, emphasis has been made in the recent strategies to create structural defects in a controlled way that generate Lewis acidity. Other sections cover examples illustrating substituted terephthalate as active sites and the evidence that there is a synergy between acid and basic sites in close proximity that make some of these UiO‐66 with substituents at the linker to act as dual acid‐base catalysts. Other sections are focused on the use of UiO‐66 as hosts of metal nanoparticles, metal oxides and other host, remarking the influence that the nature of UiO‐66 and the possible presence of substituents in the framework play on the activity of the incorporated guest. The last section summarizes the current state of the art in the use of UiO‐66 in catalysis and provides our views on future developments regarding the application of UiO‐66 in industrial processes.
Hydrostatic Pressure on Toroidal Interaction and Propeller Chirality of Hexaarylbenzenes: Explicit Solvent Effects on Differential Volumes in Methylcyclohexane and Hexane
Authors: Kosaka Tomoyo , Iwai Satono , Fukuhara Gaku , Imai Yoshitane , Mori Tadashi 
Published: November 2018

AbstractA unique and effective interaction between the peripheral aromatic blades makes hexaarylbenzenes (HABs) attractive in fundamental research as well as for various applications such as molecular wires, sensors, and supramolecular assemblies. The chiroptical responses of HABs are susceptible to environmental factors such as solvent and temperature owing to the dynamic conformational transitions between the conformers. In this study, pressure dependence on the propeller chiral HABs in two different solvents was studied in detail. The effective differential volumes for two different equilibria were determined by quantitative analyses of CD spectra, affording very large differential volumes from the propeller to toroidal conformer (ΔVT‐C) of +43 and +42 cm3 mol−1, for H2 and H6, respectively, in methylcyclohexane. The value of H6 was further enhanced to +72 cm3 mol−1 in hexane, the largest value for the typical unimolecular conformational change. Such a response of propeller chirality in HABs is expedient in designing more advanced piezo‐sensitive materials.
Real‐time hand gestures system based on leap motion
Authors: Jia Jing , Tu Geng , Deng Xin , Zhao Chuchu , Yi Wenlong 
Published: November 2018

SummaryIn the three‐dimensional human‐computer interaction, the identification of dynamic and static gestures is a very important and challenging work in the field of machine vision, In this paper, we propose a new gesture recognition system. Leap Motion device is a kind of equipment, which is specially used for hand recognition, which can get the feature data to realize the gesture recognition in real time. The system is mainly composed of the following two parts. For static gestures, we use a kind of feature information based on the distance, direction, and bending degree of the fingertip, and bring the support vector machine into the training to realize the static gesture recognition. For dynamic gestures, we use gesture length as a benchmark to reject non‐key gestures and preprocess frames with abnormal gesture sequences. The average recognition rate of static gestures reaches 99.98%, and the recognition rate of dynamic gestures reaches 96.20%. The experimental results show that the algorithm has a good effect on gesture recognition, and it is suitable for the simple interaction between gestures, people and people and daily communication of daily communication barriers.