bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capillary-Limited Evaporation From Well-Defined Microstructured Surfaces
Authors: Adera Solomon , Raj Rishi , Wang Evelyn N. 
Published: July 2018

Thermal management is increasingly becoming a bottleneck for a variety of high power density applications such as integrated circuits, solar cells, microprocessors, and energy conversion devices. The performance and reliability of these devices are usually limited by the rate at which heat can be removed from the device footprint, which averages well above 100 W/cm2 (locally this heat flux can exceed 1000 W/cm2). State-of-the-art air cooling strategies which utilize the sensible heat are insufficient at these large heat fluxes. As a result, novel thermal management solutions such as via thin-film evaporation that utilize the latent heat of vaporization of a fluid are needed. The high latent heat of vaporization associated with typical liquid-vapor phase change phenomena allows significant heat transfer with small temperature rise.
In this work, we demonstrate a promising thermal management approach where square arrays of cylindrical micropillar arrays are used for thin-film evaporation. The microstructures control the liquid film thickness and the associated thermal resistance in addition to maintaining a continuous liquid supply via the capillary pumping mechanism. When the capillary-induced liquid supply mechanism cannot deliver sufficient liquid for phase change heat transfer, the critical heat flux is reached and dryout occurs. This capillary limitation on thin-film evaporation was experimentally investigated by fabricating well-defined silicon micropillar arrays using standard contact photolithography and deep reactive ion etching. A thin film resistive heater and thermal sensors were integrated on the back side of the test sample using e-beam evaporation and acetone lift-off. The experiments were carried out in a controlled environmental chamber maintained at the water saturation pressure of ≈3.5 kPa and ≈25 °C. We demonstrated significantly higher heat dissipation capability in excess of 100 W/cm2. These preliminary results suggest the potential of thin-film evaporation from microstructured surfaces for advanced thermal management applications.
Effect of a Strong Middle Layer on Spudcan Penetration
Authors: Gao Wen , Harrup Tom , Hu Yuxia , White David 
Published: July 2018

The rapid penetration of one or more of the foundations of a mobile jack-up rig into the seabed is an ongoing major problem in the offshore industry, with the potential to cause major damage to the structure and endangering any personnel on board. A recent example is the jack-up drilling rig Perro Negro 6 incident happened near the mouth of the Congo river in July 2013 with one of the rig’s crew of 103 reported missing and six others injured. This uncontrollable displacement is due to a form of failure known as punch through failure and commonly occurs on stratified seabed profiles. It has been reported that unexpected punch-through accidents have resulted in both rig damage and lost drilling time at a rate of 1 incident per annum with consequential costs estimated at between US$1 and US$10 million [1].
This paper presents the bearing capacity profiles and associated soil flow mechanisms of a common spudcan foundation penetrating into a three layer soft-stiff-soft clay soil through the use of large deformation finite element (LDFE) analysis. The Remeshing and Interpolation with Small Strain (RITSS) [2, 3] technique was implemented in the software package AFENA [4] to conduct the LDFE analysis. Both soil layer thickness and soil layer strength ratios were varied to study their effect on the spudcan penetration responses. The LDFE results of spudcan penetration into the soft-stiff-soft clay soils were calibrated by existing centrifuge test data. A parametric study was then conducted to study the bearing capacity responses and soil flow mechanisms during spudcan large penetrations by varying the soil layer strength ratio and relative layer thickness to the diameter of spudcan.
It was found that there were three types of bearing responses during continuous penetration of spudcan: (a) when the top soft layer is relatively thin, the spudcan bearing response was similar to that of two layer soils with stiff over soft clays; (b) when the top soil layer thickness is medium, a peak resistance is observed when spudcan penetrates into the middle stiff layer followed by reduction; (c) when the soil layer is thick, the peak resistance occurs when spudcan gets into the bottom soft soil layer. The critical thickness of top soil layer is a function of soil strength ratio and middle stiff soil layer thickness. The bearing response types were also corresponding to the soil cavity formations during spudcan initial penetration.
Tracing the
De Novo
Origin of Protein-Coding Genes in Yeast
Authors: Wu Baojun , Knudson Alicia 
Published: July 2018

ABSTRACT

De novo
genes are very important for evolutionary innovation. However, how these genes originate and spread remains largely unknown. To better understand this, we rigorously searched for
de novo
genes in
Saccharomyces cerevisiae
S288C and examined their spread and fixation in the population. Here, we identified 84
de novo
genes in
S. cerevisiae
S288C since the divergence with their sister groups. Transcriptome and ribosome profiling data revealed at least 8 (10%) and 28 (33%)
de novo
genes being expressed and translated only under specific conditions, respectively. DNA microarray data, based on 2-fold change, showed that 87% of the
de novo
genes are regulated during various biological processes, such as nutrient utilization and sporulation. Our comparative and evolutionary analyses further revealed that some factors, including single nucleotide polymorphism (SNP)/indel mutation, high GC content, and DNA shuffling, contribute to the birth of
de novo
genes, while domestication and natural selection drive the spread and fixation of these genes. Finally, we also provide evidence suggesting the possible parallel origin of a
de novo
gene between
S. cerevisiae
and
Saccharomyces paradoxus
. Together, our study provides several new insights into the origin and spread of
de novo
genes.

IMPORTANCE
Emergence of
de novo
genes has occurred in many lineages during evolution, but the birth, spread, and function of these genes remain unresolved. Here we have searched for
de novo
genes from
Saccharomyces cerevisiae
S288C using rigorous methods, which reduced the effects of bad annotation and genomic gaps on the identification of
de novo
genes. Through this analysis, we have found 84 new genes originating
de novo
from previously noncoding regions, 87% of which are very likely involved in various biological processes. We noticed that 10% and 33% of
de novo
genes were only expressed and translated under specific conditions, therefore, verification of
de novo
genes through transcriptome and ribosome profiling, especially from limited expression data, may underestimate the number of bona fide new genes. We further show that SNP/indel mutation, high GC content, and DNA shuffling could be involved in the birth of
de novo
genes, while domestication and natural selection drive the spread and fixation of these genes. Finally, we provide evidence suggesting the possible parallel origin of a new gene.
Effects of physical activity interventions on cognitive and academic performance in children and adolescents: a novel combination of a systematic review and recommendations from an expert panel
Authors: Singh Amika S , Saliasi Emi , van den Berg Vera , Uijtdewilligen Léonie , de Groot Renate H M , Jolles Jelle , Andersen Lars B , Bailey Richard , Chang Yu-Kai , Diamond Adele , Ericsson Ingegerd , Etnier Jennifer L , Fedewa Alicia L , Hillman Charles H , McMorris Terry , Pesce Caterina , Pühse Uwe , Tomporowski Phillip D , Chinapaw Mai J M 
Published: July 2018

ObjectiveTo summarise the current evidence on the effects of physical activity (PA) interventions on cognitive and academic performance in children, and formulate research priorities and recommendations.DesignSystematic review (following PRISMA guidelines) with a methodological quality assessment and an international expert panel. We based the evaluation of the consistency of the scientific evidence on the findings reported in studies rated as of high methodological quality.Data sourcesPubMed, PsycINFO, Cochrane Central, Web of Science, ERIC, and SPORTDiscus.Eligibility criteria for selecting studiesPA-intervention studies in children with at least one cognitive or academic performance assessment.ResultsEleven (19%) of 58 included intervention studies received a high-quality rating for methodological quality: four assessed effects of PA interventions on cognitive performance, six assessed effects on academic performance, and one on both. All high-quality studies contrasted the effects of additional/adapted PA activities with regular curriculum activities. For cognitive performance 10 of 21 (48%) constructs analysed showed statistically significant beneficial intervention effects of PA, while for academic performance, 15 of 25 (60%) analyses found a significant beneficial effect of PA. Across all five studies assessing PA effects on mathematics, beneficial effects were reported in six out of seven (86%) outcomes. Experts put forward 46 research questions. The most pressing research priority cluster concerned the causality of the relationship between PA and cognitive/academic performance. The remaining clusters pertained to PA characteristics, moderators and mechanisms governing the ‘PA–performance’ relationship and miscellaneous topics.ConclusionThere is currently inconclusive evidence for the beneficial effects of PA interventions on cognitive and overall academic performance in children. We conclude that there is strong evidence for beneficial effects of PA on maths performance.The expert panel confirmed that more ‘high-quality’ research is warranted. By prioritising the most important research questions and formulating recommendations we aim to guide researchers in generating high-quality evidence. Our recommendations focus on adequate control groups and sample size, the use of valid and reliable measurement instruments for physical activity and cognitive performance, measurement of compliance and data analysis.PROSPERO registration numberCRD42017082505.
Reviewing progress in public involvement in NIHR research: developing and implementing a new vision for the future
Authors: Staniszewska Sophie , Denegri Simon , Matthews Rachel , Minogue Virginia 
Published: July 2018

ObjectivesTo review the progress of public involvement (PPI) in NIHR (National Institute for Health Research) research, identify barriers and enablers, reflect on the influence of PPI on the wider health research system in the UK and internationally and develop a vision for public involvement in research for 2025. The developing evidence base, growing institutional commitment and public involvement activity highlight its growth as a significant international social movement.DesignThe ‘Breaking Boundaries Review’ was commissioned by the Department of Health. An expert advisory panel was convened. Data sources included: an online survey, international evidence sessions, workshop events, open submission of documents and supporting materials and existing systematic reviews. Thematic analysis identified key themes. NVivo was used for data management. The themes informed the report’s vision, mission and recommendations, published as ‘Going the Extra Mile—Improving the health and the wealth of the nation through public involvement in research’. The Review is now being implemented across the NIHR.ResultsThis paper reports the Review findings, the first of its type internationally. A range of barriers and enablers to progress were identified, including attitudes, resources, infrastructure, training and support and leadership. The importance of evidence to underpin practice and continuous improvement emerged. Co-production was identified as a concept central to strengthening public involvement in the future. The Vision and Mission are supported by four suggested measures of success, reach, refinement, relevance and relationships.ConclusionsThe NIHR is the first funder of its size and importance globally to review its approach to public involvement. While significant progress has been made, there is a need to consolidate progress and accelerate the spread of effective practice, drawing on evidence. The outcomes of the Review are being implemented across the NIHR. The findings and recommendations have transferability for other organisations, countries and individuals.
Global implementation survey of Integrated Management of Childhood Illness (IMCI): 20 years on
Authors: Boschi-Pinto Cynthia , Labadie Guilhem , Dilip Thandassery Ramachandran , Oliphant Nicholas , Dalglish Sarah L , Aboubaker Samira , Agbodjan-Prince Olga Adjoa , Desta Teshome , Habimana Phanuel , Butron-Riveros Betzabe , Al-Raiby Jamela , Siddeeg Khalid , Kuttumuratova Aigul , Weber Martin , Mehta Rajesh , Raina Neena , Daelmans Bernadette , Diaz Theresa 
Published: July 2018

ObjectiveTo assess the extent to which Integrated Management of Childhood Illness (IMCI) has been adopted and scaled up in countries.SettingThe 95 countries that participated in the survey are home to 82% of the global under-five population and account for 95% of the 5.9 million deaths that occurred among children less than 5 years of age in 2015; 93 of them are low-income and middle-income countries (LMICs).MethodsWe conducted a cross-sectional self-administered survey. Questionnaires and data analysis focused on (1) giving a general overview of current organisation and financing of IMCI at country level, (2) describing implementation of IMCI’s three original components and (3) reporting on innovations, barriers and opportunities for expanding access to care for children. A single data file was created using all information collected. Analysis was performed using STATA V.11.ParticipantsIn-country teams consisting of representatives of the ministry of health and country offices of WHO and Unicef.ResultsEighty-one per cent of countries reported that IMCI implementation encompassed all three components. Almost half (46%; 44 countries) reported implementation in 90% or more districts as well as all three components in place (full implementation). These full-implementer countries were 3.6 (95% CI 1.5 to 8.9) times more likely to achieve Millennium Development Goal 4 than other (not full implementer) countries. Despite these high reported implementation rates, the strategy is not reaching the children who need it most, as implementation is lowest in high mortality countries (39%; 7/18).ConclusionThis survey provides a unique opportunity to better understand how implementation of IMCI has evolved in the 20 years since its inception. Results can be used to assist in formulating strategies, policies and activities to support improvements in the health and survival of children and to help achieve the health-related, post-2015 Sustainable Development Goals.
Scoping review assessing the evidence used to support the adoption of mobile health (mHealth) technologies for the education and training of community health workers (CHWs) in low-income and middle-income countries
Authors: Winters Niall , Langer Laurenz , Geniets Anne 
Published: July 2018

ObjectivesUndertake a systematic scoping review to determine how a research evidence base, in the form of existing systematic reviews in the field of mobile health (mHealth), constitutes education and training for community health workers (CHWs) who use mobile technologies in everyday work. The review was informed by the following research questions: does educational theory inform the design of the education and training component of mHealth interventions? How is education and training with mobile technology by CHWs in low-income and middle-income countries categorised by existing systematic reviews? What is the basis for this categorisation?SettingThe review explored the literature from 2000 to 2017 to investigate how mHealth interventions have been positioned within the available evidence base in relation to their use of formal theories of learning.ResultsThe scoping review found 24 primary studies that were categorised by 16 systematic reviews as supporting CHWs’ education and training using mobile technologies. However, when formal theories of learning from educational research were used to recategorise these 24 primary studies, only four could be coded as such. This identifies a problem with how CHWs’ education and training using mobile technologies is understood and categorised within the existing evidence base. This is because there is no agreed on, theoretically informed understanding of what counts as learning.ConclusionThe claims made by mHealth researchers and practitioners regarding the learning benefits of mobile technology are not based on research results that are underpinned by formal theories of learning. mHealth suffers from a reductionist view of learning that underestimates the complexities of the relationship between pedagogy and technology. This has resulted in miscategorisations of what constitutes CHWs’ education and training within the existing evidence base. This can be overcome by informed collaboration between the health and education communities.
Effect of multiple risk behaviours in adolescence on educational attainment at age 16 years: a UK birth cohort study
Authors: Wright Caroline , Kipping Ruth , Hickman Matthew , Campbell Rona , Heron Jon 
Published: July 2018

ObjectivesTo explore the association between adolescent multiple risk behaviours (MRBs) and educational attainment.DesignProspective population-based UK birth cohort study.SettingAvon Longitudinal Study of Parents and Children (ALSPAC), a UK birth cohort of children born in 1991–1992.ParticipantsData on some or all MRB measures were available for 5401 ALSPAC participants who attended a clinic at age 15 years and/or completed a detailed questionnaire at age 16 years. Multiple imputation was used to account for missing data.Primary outcome measuresCapped General Certificate of Secondary Education (GCSE) score and odds of attaining five or more GCSE examinations at grades A*–C. Both outcome measures come from the National Pupil Database and were linked to the ALSPAC data.ResultsEngagement in MRB was strongly associated with poorer educational attainment. Each additional risk equated to −6.31 (95% CI −7.03 to −5.58, p<0.001) in capped GCSE score, equivalent to a one grade reduction or reduced odds of attaining five or more A*–C grades of 23% (OR 0.77, 95% CI 0.74 to 0.81, p<0.001). The average cohort member engaged in 3.24 MRB and therefore have an associated reduction in GCSE score equivalent to three and a half grades in one examination, or reduced odds of attaining five or more A*–C grades of 75%.ConclusionEngagement in adolescent MRB is strongly associated with poorer educational attainment at 16 years. Preventing MRB could improve educational attainment and thereby directly and indirectly improve longer-term health.
Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period
Authors: Forster Sarah , Housley Gemma , McKeever Tricia M , Shaw Dominick E 
Published: July 2018

ObjectiveEarly Warning Scores (EWSs) are used to monitor patients for signs of imminent deterioration. Although used in respiratory disease, EWSs have not been well studied in this population, despite the underlying cardiopulmonary pathophysiology often present. We examined the performance of two scoring systems in patients with respiratory disease.DesignRetrospective cohort analysis of vital signs observations of all patients admitted to a respiratory unit over a 2-year period. Scores were linked to outcome data to establish the performance of the National EWS (NEWS) compared results to a locally adapted EWS.SettingNottingham University Hospitals National Health Service Trust respiratory wards. Data were collected from an integrated electronic observation and task allocation system employing a local EWS, also generating mandatory referrals to clinical staff at set scoring thresholds.Outcome measuresProjected workload, and sensitivity and specificity of the scores in predicting mortality based on outcome within 24 hours of a score being recorded.Results8812 individual patient episodes occurred during the study period. Overall, mortality was 5.9%. Applying NEWS retrospectively (vs local EWS) generated an eightfold increase in mandatory escalations, but had higher sensitivity in predicting mortality at the protocol cut points.ConclusionsThis study highlights issues surrounding use of scoring systems in patients with respiratory disease. NEWS demonstrated higher sensitivity for predicting death within 24 hours, offset by reduced specificity. The consequent workload generated may compromise the ability of the clinical team to respond to patients needing immediate input. The locally adapted EWS has higher specificity but lower sensitivity. Statistical evaluation suggests this may lead to missed opportunities for intervention, however, this does not account for clinical concern independent of the scores, nor ability to respond to alerts based on workload. Further research into the role of warning scores and the impact of chronic pathophysiology is urgently needed.
Epidemiology and aetiologies of cryptococcal meningitis in Africa, 1950–2017: protocol for a systematic review
Authors: Nyazika Tinashe K , Tatuene Joseph Kamtchum , Kenfak-Foguena Alain , Verweij Paul E , Meis Jacques F , Robertson Valerie J , Hagen Ferry 
Published: July 2018

IntroductionCryptococcal meningitis is a neglected disease and an AIDS-defining illness, responsible for 15% of all AIDS-related deaths globally. In 2014, the estimated number of incident cryptococcal meningitis cases was 223 100, with 73% of them occurring in Africa. Currently available data on the prevalence, incidence, aetiologies and mortality of cryptococcal meningitis across Africa are sparse and of limited quality. We propose to conduct the first systematic review to summarise the epidemiological data available on cryptococcal meningitis and its aetiological causes in Africa.Methods and analysisWe will search PubMed, MEDLINE, Excerpta Medica Database, ISI Web of Science, Africa Index Medicus, Cumulative Index to Nursing and Allied Health for studies on cryptococcal meningitis published between 1st January 1950 and 31st December 2017, involving adults and/or children residing in Africa. After study selection, full text paper acquisition and data extraction, we will use validated tools and checklists to assess the quality of reporting and risk of bias for each study. Heterogeneity across studies will be assessed using the χ2test on Cochrane’s Q statistic and a random effect meta-analysis will be used to estimate the overall prevalence, incidence density and mortality of cryptococcal meningitis across studies with similar characteristics. This protocol is prepared and presented in accordance with the 2015 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. Reporting of the results will be compliant with the Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) guidelines.Ethics and disseminationThere is no requirement for ethical approval since we will be using data from published studies. The final report will be published in a peer-reviewed journal and further presented at conferences. This study is expected to provide useful contextual estimates needed to inform treatment policies on the African continent and assess the impact of diagnostic and prevention strategies on the burden of cryptococcal meningitis in the post antiretroviral therapy era.PROSPERO registration numberCRD42017081312.