bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zingerone Facilitates Apoptosis in Triple Negative Breast Cancer Cells by Inducing Autophagy
Authors: Cao Xia , Chen Chien‐Wei , Yin Kai , Wang Tzong‐Luen , Huang Yao‐Kuang , Chen Pang‐Yen , Su Po‐Hua 
Published: December 2024

ABSTRACTTriple negative breast cancer (TNBC) is characterized by high heterogenicity and aggressiveness and autophagy plays a complicated role in cancer development. Zingerone is reported to possess multiple pharmacological activities, including antitumors. This study explored the biological role and the relevant mechanisms of zingerone in TNBC. Following zingerone treatment, the viability of normal breast cancer cells MCF‐10A and TNBC cells (MDA‐MB‐231 and MDA‐MB‐468) was detected with CCK‐8 assay. The proliferation, migration and invasion of TNBC cells were detected with colony formation, wound healing, and transwell assays. Western blot was used to detect the expressions of migration‐, apoptosis‐ and autophagy‐related proteins. Flow cytometry was used to detect the cell apoptotic level and immunofluorescence assay measured the autophagy. The experimental data revealed that zingerone with varying concentrations suppressed cell viability, proliferation, migration and invasion while promoting the apoptosis in TNBC, which might be mediated by autophagy activation. Besides, zingerone decreased HDAC1 expression in TNBC cells and regulated autophagy via HDAC1. Collectively, zingerone impeded the malignant progression of TNBC via inducing HDAC1‐mediated autophagy.
Multitask learning for automatic detection of meniscal injury on 3D knee MRI
Authors: Wang Yufan , Ying Mengjie , Yang Yangyang , Chen Yankai , Wang Haoyuan , Tsai Tsung‐Yuan , Liu Xudong 
Published: December 2024

AbstractMagnetic resonance imaging (MRI) of the knee is the recommended diagnostic method before invasive arthroscopy surgery. Nevertheless, interpreting knee MRI scans is a time‐consuming process that is vulnerable to inaccuracies and inconsistencies. We proposed a multitask learning network MCSNetatt which efficiently introduces segmentation prior features and enhances classification results through multiscale feature fusion and spatial attention modules. The MRI studies and subsequent arthroscopic diagnosis of 259 knees were collected retrospectively. Models were trained based on multitask loss with coronal and sagittal sequences and fused using logistic regression (LR). We visualized the network's interpretability by the gradient‐weighted class activation mapping method. The LR model achieved higher area under the curve and mean average precision of medial and lateral menisci than models trained on a single sagittal or coronal sequence. Our multitask model MCSNetat outperformed the single‐task model CNet and two clinicians in classification, with accuracy, precision, recall, F1‐score of 0.980, 1.000, 0.952, 0.976 for medial and 0.920, 0.905, 0.905, 0.905 for the lateral, respectively. With the assistance of model results and visualized saliency maps, both clinicians showed improvement in their diagnostic performance. Compared to the baseline segmentation model, our model improved dice similarity coefficient and the 95% Hausdorff distance (HD95) of the lateral meniscus for 2.3% and 0.860 mm in coronal images and 4.4% and 2.253 mm in sagittal images. Our multitask learning network quickly generated accurate clinicopathological classification and segmentation of knee MRI, demonstrating its potential to assist doctors in a clinical setting.
Highly Efficient Novel Garnet‐Structured Yellow Emitting Phosphor for High Power Laser‐Driven Lighting
Authors: Duan Jiarui , Bai Chen , Sun Jiacheng , Wang Deyin , Wang Yuhua 
Published: December 2024

AbstractA novel blue light excitable yellow emitting phosphor, BaLu2(Mg0.6Al2.8Si1.6)O12:Ce3+, with an external quantum efficiency (EQE) of 66.2%, is developed by substituting Al3+‐Al3+ pairs in BaLu2Al4SiO12:Ce3+ with Mg2+‐Si4+ pairs. Alongside the redshift of Ce3+ emission, this substitution also broadened Ce3+ emission and reduced its thermal stability. The spectral changes are found to result from variations in the local crystal field and site symmetry of Ce3+ due to Mg2+‐Si4+ substitution. To assess the feasibility of the newly developed yellow‐emitting phosphor for high‐power laser lighting, it is constructed into a phosphor wheel. Owing to the efficient heat dissipation via high speed rotation of phosphor wheel, the yellow phosphor exhibit a luminous flux of 3894 lm and shows no obvious emission saturation even excited by blue laser light with a power density of 90.7 W mm−2. Exciting the yellow phosphor wheel with a blue laser diode (LDs) at a power density of 25.2 W mm−2 resulted in bright white light with a luminous of 1718.1 lm, a correlated color temperature of 5983 K, a color rendering index of 65.0, and chromatic coordinates of (0.3203, 0.3631). These results suggest that the newly synthesized yellow‐emitting phosphor holds significant potential for high‐power laser‐driven lighting applications.
Wogonin Inhibits Ovarian Cancer by Activating the AMPK‐TET2‐5hmC Axis
Authors: Yang Shu‐Yi , Jhang Jing‐Siang , Huang Wen‐Long , Tsai Leah H. J. , Tsai Min‐Chia , Chan Chin‐Pui , Lin Ru‐Inn , Lin Hon‐Yi , Li Chin , Yeh Chia‐Chou , Chan Michael W. Y. 
Published: December 2024

ABSTRACTOvarian cancer is one of the most common gynecologic cancers. In the quest for effective anti‐cancer agents, this study explores the effects of wogonin, a naturally occurring flavonoid, on the viability and migration of A2780 and Kuramochi ovarian cancer cells. A2780 and Kuramochi human ovarian cancer cell lines were utilized. Cytotoxicity and migration were evaluated using the CCK8 assay and the wound‐healing assay, respectively. The effect of wogonin on the growth of A2780 ovarian cancer cells in vivo was assessed using a nude mouse model. The phosphorylation and half‐life of AMPK were determined by western blot analysis. The level of 5hmC was assessed using dot blot analysis. The impact of wogonin on gene expression was examined through RNA‐Seq. Our results show that wogonin not only impedes cancer cell growth and mobility both in vitro and in vivo but also significantly increases the cytotoxicity of cisplatin. Investigations of the mechanism underlying these effects reveal that wogonin suppresses genes associated with cell proliferation and the EMT and upregulates metabolic pathways, particularly the AMPK signaling pathway, which is crucial for increasing 5hmC levels. These results indicate that wogonin promotes DNA demethylation by stabilizing TET2. In conclusion, our findings highlight not only the therapeutic potential of wogonin but also its preventative capability against ovarian cancer in individuals with metabolic disorders, such as diabetes, who are at increased risk of ovarian cancer.
Erfahrungsbericht: Laborjournal digital
Authors: Bender Theo 
Published: December 2024

AbstractUm die Zettelwirtschaft einzudämmen, hat die Universität Würzburg ein elektronisches Laborjournal für die ganze Hochschule eingeführt. Wie das gelungen ist und was das bringt, erzählen ein Masterstudent, ein Professor und zwei IT‐Kräfte der Universität.
Comparison of mechanical and physical behaviors of carbon/basalt/epoxy hybrid composite rod with carbon/glass/epoxy hybrid composite rod used in ACCC conductor core
Authors: Parvizi Pooya , Jalilian Milad , Dearn Karl D. 
Published: December 2024

AbstractThe demand for increased distribution capacity in transmission lines has led to the growing use of hybrid composite rods as the reinforcing core of Aluminum Conductor Composite Core overhead conductors, known as ACCC. These rods usually consist of a carbon fiber‐reinforced epoxy matrix composite core surrounded by an outer shell made of a glass fiber‐reinforced epoxy matrix composite. The outer shell composite can be reinforced with basalt fibers, which are being used more frequently due to their favorable properties. In this research, mechanical properties such as flexural strength, physical properties including density and electrical resistance, and thermal behavior of carbon/basalt/epoxy (CBE) and also carbon/glass/epoxy (CGE) hybrid composite rods fabricated by the pultrusion process have been investigated. The CBE composite exhibited approximately 4% higher mean flexural strength than CGE. Additionally, the CBE composite showed higher thermal stability, as indicated by Thermogravimetric Analysis (TGA). The CGE composite has about 4% higher density than the CGE composite, leading to higher mass per unit length of the resultant ACCC conductor. Finally, the fracture surfaces of hybrid composite rods have been studied using scanning electron microscopy (SEM). The results indicate the better mechanical and thermal properties of carbon/basalt/epoxy hybrid composite rods.Highlights
Growing use of hybrid composite rods in ACCC overhead conductors.
Hybrid composite rods have a carbon fiber core and glass‐reinforced outer shell.
Basalt fibers increasingly used to reinforce the outer shell composite.
Pultrusion process used for producing the hybrid composite rods.
Fracture surfaces of hybrid composite rods studied using SEM.
A multicenter, single‐group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention‐deficit/hyperactivity disorder: Study protocol
Authors: Takamatsu Naoki , Nakashima Misuzu , Matsuura Kei , Umemoto Ikue , Ito Masaya , Kanazawa Junichiro , Tomiyama Hirofumi , Kondo Masaki , Tachimori Hisateru , Nakao Tomohiro , Horikoshi Masaru , Kuga Hironori 
Published: December 2024

AbstractBackgroundAttention‐deficit/hyperactivity disorder (ADHD) symptoms, including executive function, emotional regulation, and motivation, can persist into adulthood and are often associated with mental illnesses. Cognitive behavioral therapy (CBT) may help ADHD adults in Japan, but the lack of studies and the variability in group CBT approaches make its effects unclear. Japan lacks unified CBT programs and adult ADHD guidelines, making it difficult to implement international individual CBT recommendations due to cultural differences. This study will assess the feasibility of a novel CBT program for Japanese adult ADHD patients.MethodsThis feasibility study will be open, nonrandomized, single‐arm, multicenter study. Twelve ADHD patients aged 20–65 years who are currently receiving treatment will be included based on Conners' Adult ADHD Rating Scale (CAARS) clinical severity threshold. An intervention phase of 12–16 weeks and a 12‐week follow‐up will total 24–28 weeks for all participants. The intervention will use a new CBT program tailored to individual assessments.ResultsThe primary objective is to determine feasibility using dropout rates, adverse events, and CAARS score changes between Weeks 1 and 16. The secondary outcomes will assess long‐term effects of treatment beyond the intervention period and provide descriptive statistics on sex, depression, quality of life, and autistic scores in relation to the intervention outcomes. The full analysis set and per protocol set will be used for statistical analysis.ConclusionsThis study is essential for the development of CBT interventions in accordance with Japan's healthcare system that are tailored to the unique needs of its population.
Adding Oscillometry and Fractional Exhaled Nitric Oxide to Guidelines Potentially Enhances Identification of Exacerbation Risk Factors in Asthmatic Children
Authors: Galant Stanley P. , Morphew Tricia 
Published: December 2024

ABSTRACTBackgroundA possible explanation for the continued risk of asthma exacerbations while utilizing current asthma guideline‐based management is the failure to consider small airway dysfunction (SAD) and eosinophilic airway inflammation in assuming asthma‐controlled status.ObjectiveTo construct a practical algorithm that potentially identifies additional risks of not well‐controlled (NWC) asthma and exacerbations beyond guideline criteria with oscillometry and fractional exhaled nitric oxide (FENO) determination.MethodsThis was a retrospective, posthoc analysis of 183 children, ages 4–18 years, with moderate‐to‐severe asthma, characterized by demographic factors, National Health Lung and Blood Institute (NHLBI) determined asthma‐controlled status, therapy step, and lung function status. Impulse oscillometry (IOS) and FENO were performed before spirometry. Abnormal lung function values were determined for spirometry, SAD, and FENO based on established thresholds. Statistical analysis included a decision tree and Venn diagram.ResultsFor 53 patients with guideline‐based NWC, 15 (28.3%) had an FEV1 ≤ 80% predicted. An additional 30 patients (56.6%) had abnormal SAD and/or FENO with a preserved FEV1. Of 130 patients, well‐controlled (WC) by guidelines 76 (58.5%) exhibited SAD and/or abnormal FENO.ConclusionsThese data demonstrate that over 50% of WC patients with moderate‐to‐severe asthma, with few symptoms and preserved FEV1, had SAD and/or abnormal FENO levels, suggesting the potential of early phenotype‐specific therapy to prevent risk of future exacerbations.
Prevalence and Distribution of Musculoskeletal Symptoms in Cystic Fibrosis and Impacts on Daily Life
Authors: Clarke Elizabeth , Taylor Julia , Watson Pippa , Freeston Jane , Jones Andrew , Peckham Daniel , Horsley Alex 
Published: December 2024

ABSTRACTBackgroundMusculoskeletal problems are reported in the literature as a common problem for people with cystic fibrosis, with a range of aetiologies including an inflammatory arthritis. However, accurate data on the presentations and prevalence are lacking. The aim of this cohort study was to describe the scale and impact of musculoskeletal symptoms in CF.MethodsA collaboratively designed questionnaire was administered to adults attending two large UK CF centres. Data collected evaluated scale and impact of musculoskeletal symptoms.ResultsResults were obtained from 489 patients (response rate 59%). Of these, 49% reported that musculoskeletal symptoms impacted their activities of daily living in the previous year. Back pain was common, occurring in 44% of participants in the preceding week. The knee was the most commonly affected painful peripheral joint, with 26% of participants reporting knee pain within the last week rising to 50% within the last year. Early morning stiffness and joint swelling were markedly less common, suggesting that the majority of musculoskeletal pain in CF is not due to an inflammatory arthritis but is due to other factors.ConclusionMusculoskeletal problems are common in CF and frequently affect activities of daily living. Symptoms of inflammatory arthritis occurred in only a small minority of individuals. A focused approach to characterising and clarifying the aetiology of musculoskeletal symptoms is needed to inform the management of these disabling symptoms.
Creation of Gas‐Phase Organo‐Uranium Species by Removal of “yl” Oxo Ligands From UO22+ Carboxylate Precursor Ions
Authors: Lenze Samuel J. , Terhorst Justin , Ihabi Amina , Corcovilos Theodore , van Stipdonk Michael J. 
Published: December 2024

ABSTRACTRationaleThese experiments were conducted to measure the diversity of organo‐U (IV) and U (III) ions created using multiple‐stage tandem MS and collision‐induced dissociation of halogen‐substituted UVIO2‐phenide complexes [UO2(C6H3FX)]+, X = Cl, Br, or I.MethodsSamples of UO2(O2C‐C6H3FX)2 were prepared by digesting UO3 with appropriate halogen‐substituted carboxylic acids in deionized water. Solutions for ESI were created by diluting the digested sample in 50:50 H2O/CH3OH. Precursor ions for multiple‐stage tandem MS were generated by electrospray ionization (ESI). Multiple‐stage collision‐induced dissociation (He collision gas) in a linear quadrupole ion trap mass spectrometer was used to prepare species such as [UIVFX(C≡CH)]+ and UIIIF(C≡CH)]+ for subsequent study of ion‐molecule reactions with adventitious neutrals in the ion trap.ResultsMultiple‐stage CID of the [UO2(C6H3FX)]+, X = Cl, Br, or I, complexes caused removal of both “yl” oxo ligands from of the UO22+ moiety to create ions such as [UIVFX(C≡CH)]+ and [UIIIFX]+. For [UIVFXC≡CH]+ and [UIIIFC≡CH]+ products, hydrolysis to generate [UIVFX (OH)]+ and [UIIIF (OH)]+, with concomitant loss of HC≡CH, was observed. CID of [UO2(C6H3FBr)]+ and [UO2(C6H3FI)]+ caused reductive elimination of the respective halogen radicals to generate interesting organo‐U (III) species such as [UIIIF(C≡CH)]+ and [UIIIC2]+.ConclusionsThe use of “preparative” tandem mass spectrometry and a suite of halogen substituted benzoic acid ligands can be used to remove both oxo ligands of UO22+ and generate a group of homologous organo‐U (IV) and organo‐U (III) ions for studies of intrinsic reactivity.
Assessment of Serum Metabolism and Eicosanoid Profiling in Pediatric Asthma and Bronchiolitis via Liquid Chromatography‐Mass Spectrometry
Authors: Gao Xiao‐huan , Yin Tian‐lu , Li Yan , Shi Su‐fang , Liu Feng‐li , Li Miao‐jing , Liu Rui‐xin , Liu Qing , Xu Yan‐li 
Published: December 2024

ABSTRACTBackgroundAsthma, a prevalent chronic inflammatory respiratory disease among children, was the focus of this study. Serum metabolism profiles were examined in patients diagnosed with both asthma and bronchiolitis by using ultra‐high performance liquid chromatography‐mass spectrometry.MethodsIn this study, the serum samples from three distinct groups—comprising patients diagnosed with asthma, bronchiolitis, and a healthy control group—underwent comprehensive non‐targeted metabolomics analysis and targeted eicosanoid profiling.ResultsThrough both univariate and multivariate analyses, significant associations were observed between the pathophysiology of both asthma and bronchiolitis and aberrations in the metabolism of polyunsaturated fatty acids, amino acids, purines, and pathways involving cyclooxygenases and lipoxygenases, indicative of inflammatory processes and immune responses. Furthermore, metabolic changes in phosphatidylethanolamine, saturated and monounsaturated fatty acids, and bile acids were observed in the asthma group. Bronchiolitis was distinguished by disruptions in acyl carnitine and phosphatidylcholine metabolism.ConclusionThis study offers a new perspective on understanding the interplay of pathogenic mechanisms underlying both asthma and bronchiolitis. Its findings are significant for enhancing the diagnostic and therapeutic strategies tailored to asthma stemming from bronchiolitis.
Assessment of Physicochemical Properties and Consumer Preferences in Cherry Tomato Cultivars Observe under Growing Climates and Watering Regimens
Authors: Kusumiyati Kusumiyati , Ahmad Farhan , Soleh Mochamad Arief , Khan Muhammad Rabnawaz 
Published: December 2024

ABSTRACTThe physicochemical and antioxidant qualities of cherry tomatoes are getting more and more valued, and this has a significant effect on consumer choices and market dynamics. With irrigation schedules of 100%, 75%, and 50% field capacity, Ruby and Fortesa cultivars were grown in a greenhouse, rain shelter, and screen house climates in this experiment, which used a Randomized Complete Block Design (RCBD) factorial technique. The chroma value, flavonoid content, phenolic content, vitamin C content, and antioxidant activity of cherry tomatoes are the main quality parameters investigated in this study, along with the effects of cultivars, growing climates, and watering regimens. According to the results, the cultivar significantly affected chroma value, with Fortesa showing the highest value. Cultivar and growing climate significantly affected flavonoid content, with Fortesa and rain shelter environments exhibiting the most significant values. Cultivar and growing climate significantly impacted vitamin C content; ruby and greenhouse conditions produced the maximum amounts. Across all parameters, there were significant variances in antioxidant activity; Ruby showed the maximum activity, and the rain shelter provided the ideal growing environment. The market analysis conducted for the study reveals that higher‐quality cherry tomatoes are famous among upscale and health‐conscious consumers due to their high flavonoid and phenolic content, brilliant chroma value, and considerable antioxidant activity. With the help of this research, targeted cultivation techniques and marketing strategies may be created to cater to specific consumer desires and maximize market positioning and profitability.
Cognitive Biases in Mohs Micrographic Surgery
Authors: Dubash Faisal , Affleck Andrew , O’Reilly Marese , Gross Kenneth G. 
Published: December 2024

Abstract
Mohs surgeons' fallibility is an important topic to explore. There are no studies on the role of cognitive biases in heuristic decision-making within Mohs micrographic surgery (MMS) as a contributing factor in mistakes or errors of clinical judgement. We reviewed established cognitive biases applied to heuristics during the pre-operative, intraoperative and reconstruction stages of MMS, and recommend conscious cognitive bias mitigating strategies for Mohs surgeons. Clinical errors/incidents may be reframed as opportunities to learn and develop, rather than evidence of competency or status. These experiences offer the opportunity to sharpen skills within metacognition and allow for more cognizant Mohs surgeons. We highly recommend all Mohs surgeons develop in-depth knowledge and maintain awareness of cognitive biases throughout clinical practice, to enhance clinical performance.
High‐Performance Broad‐Spectrum UV Photodetectors with Uniform Response: Engineering β‐Ga2O3:Si/GaN:Si Heterojunctions via Thermal Oxidation for Optoelectronic Logic Gate and Multispectral Imaging
Authors: Jiang Jili , Luo Jiangshuai , Ding Ke , Tang Yan , Zhang Hong , Ye Lijuan , Pang Di , Li Honglin , Li Wanjun 
Published: December 2024

AbstractDeveloping high‐performance, broad‐spectrum ultraviolet photodetectors (PDs) with uniform response is crucial for optoelectronic applications like spectral analysis, optoelectronic logic gates, and multispectral imaging. This study constructs n‐n type β‐Ga2O3:Si/GaN:Si heterojunction PDs using thermal oxidation, combining the advantages of β‐Ga2O3:Si and GaN:Si for excellent broad‐spectrum response (UV‐A to UV‐C). A proposed channel model for GaN:Si oxidation includes hole formation, vortex structure development, channel formation, and grain growth, providing a basis for understanding β‐Ga2O3:Si/GaN:Si heterojunction formation. Uniform Si doping in the β‐Ga2O3 layer, achieved through thermal oxidation, reduces resistivity, enhances the collection of photogenerated carriers from the underlying GaN layer, and hence enhances broad‐spectrum response performance. The devices exhibit outstanding uniformity and sensitivity across the UV‐A to UV‐C range, with a peak responsivity of 2.44 × 104 A W−1 and a photocurrent‐to‐dark current ratio of 1.3 × 105. Applications include optoelectronic logic gates executing “OR gate” and “AND gate” logic operations with 254 and 365 nm UV light, and a single‐pixel multispectral imaging system producing high‐contrast, clear “CNU” images with 254, 295, and 365 nm UV light. This research advances the understanding of oxide heterojunction formation and offers a method for developing high‐performance, uniformly responsive broad‐spectrum UV photodetectors for optoelectronic applications.