bluuebunny/crossref_metadata_2025_split huggingface dataset:
When do Dynamic Capabilities Lead to Competitive Advantage? The Importance of Strategic Fit
Authors: Fainshmidt Stav , Wenger Lucas , Pezeshkan Amir , Mallon Mark R. 
Published: October 2018

AbstractRecent studies suggest the relationship between dynamic capabilities and competitive advantage may be jointly affected by organizational and environmental factors. We enrich this nascent perspective by developing a configurational theoretical framework – underpinned by the mechanism of strategic fit – wherein dynamic capabilities lead to a competitive advantage when they support a strategic orientation appropriate for the levels of dynamism and munificence in the environment. Results of a fuzzy‐set Qualitative Comparative Analysis using primary data show that dynamic capabilities lead to a competitive advantage in dynamic, munificent environments by enabling the combination of differentiation and low‐cost orientations. In stable, non‐munificent environments, dynamic capabilities are effective in support of a low‐cost orientation. The central insight of this study is that the relationship between dynamic capabilities and competitive advantage is contingent upon the strategic fit between organizational and environmental factors, contributing to a more rigorous and configurational dynamic capabilities view.
How do Scientists Contribute to the Performance of Innovative Start‐ups? An Imprinting Perspective on Open Innovation
Authors: Hahn Davide , Minola Tommaso , Eddleston Kimberly A. 
Published: October 2018

AbstractOur study illustrates how scientists contribute to the performance of innovative start‐ups through an analysis of 211 Italian start‐ups with and without scientist founders. Building upon imprinting theory, we hypothesize and find that scientists provide an advantage to innovative start‐ups to the extent that they stimulate open innovation (i.e., search breadth and depth). However, for this to effectively occur, the involvement of multiple scientist founders is needed, so that their career imprints internalized in the lab are successfully transferred to the start‐up. Moreover, if the start‐up embraces business practices (i.e., strategic planning) or departs from scientific logics (i.e., pursuing non‐commercial goals), scientists’ contribution is further increased. Therefore, our study illustrates how the scientist career imprint can provide an advantage to innovative start‐ups with multiple scientists, but also how it can act as a rigidity if the start‐up does not pursue strategic planning or emphasizes non‐commercial goals.
Structure and correlates of interpersonal problems and sensitivities
Authors: Hopwood Christopher J. , Good Evan W. 
Published: October 2018

AbstractObjectiveInterpersonal dysfunction is an important marker of individual differences in personality and well‐being. Existing research on interpersonal dysfunction focuses primarily on the problematic behaviors of individuals without considering how sensitivity to others’ behavior impacts functioning. In this study, we test the structure and correlates of a model of relationship dysfunction that integrates the problems individuals bring to relationships with their sensitivities to others’ behavior. We specifically examine the conjoint structure of interpersonal problems and sensitivities using a circumplex framework and associations between dimensions derived from this structure and personality, well‐being, attachment, and response style variables.MethodWe evaluated competing measurement models and examined validity correlations of interpersonal problems and sensitivities in two samples (Study 1: N = 955; 79.2% women; Mage = 19.43; Study 2: N = 1,005; 72.1% women; Mage = 19.77).ResultsSix factors capturing general (nonspecific problems and sensitivities) and stylistic (warmth and dominance for both problems and sensitivities) variation in interpersonal dysfunction were empirically distinguishable and provided incremental information about external criteria.ConclusionsResults support problems and sensitivities as overlapping but distinct sources of information about interpersonal dysfunction, and they specifically suggest an integrative six‐factor model with considerable potential for future research.
Melatonin protects against paraquat‐induced damage during in vitro maturation of bovine oocytes
Authors: Pang Yun‐Wei , Jiang Xiao‐Long , Wang Ya‐Chun , Wang Yang‐Yang , Hao Hai‐Sheng , Zhao Shan‐Jiang , Du Wei‐Hua , Zhao Xue‐Ming , Wang Lin , Zhu Hua‐Bin 
Published: October 2018

AbstractParaquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ‐induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro‐produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic‐related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ‐exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ‐induced p38 mitogen‐activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl‐histone H3 lysine 4 (H3K4me3) and trimethyl‐histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ‐induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning.
GEMS, hydrated chondritic IDPs, CI‐matrix material: Sources of water in 81P/comet Wild 2
Authors: Rietmeijer Frans J. M. 
Published: October 2018

AbstractSo far there is no conclusive evidence for water in the nucleus of 81P/comet Wild 2. Recently magnetite in collected Wild 2 samples was cited as proxy evidence for parent body aqueous alteration in this comet (Hicks et al. ). A potentional source for water of hydration would be layer silicates but unfortunately there is no record, neither texturally nor chemically, for hydrated layer silicates that survived hypervelocity impact in the Wild 2 samples. This paper reports large vesicles in the matrix of allocation C2044,2,41,2,5 from a volatile‐rich type B/C Stardust track. These vesicles were probably caused by boiling water that were generated when hydrated Wild 2 silicates impacted the near‐surface silica aerogel layer. Potential water sources were partially and fully hydrated GEMS (glass with embedded metal and sulfides) and CI carbonaceous chondrite materials among the earliest dusts that experienced hydration and icy‐body formation and long‐range transport and mixing with materials from across the solar system.
Compound‐specific carbon isotope compositions of aldehydes and ketones in the Murchison meteorite
Authors: Simkus Danielle N. , Aponte José C. , Hilts Robert W. , Elsila Jamie E. , Herd Christopher D. K. 
Published: October 2018

AbstractCompound‐specific carbon isotope analysis (δ13C) of meteoritic organic compounds can be used to elucidate the abiotic chemical reactions involved in their synthesis. The soluble organic content of the Murchison carbonaceous chondrite has been extensively investigated over the years, with a focus on the origins of amino acids and the potential role of Strecker‐cyanohydrin synthesis in the early solar system. Previous δ13C investigations have targeted α‐amino acid and α‐hydroxy acid Strecker products and reactant HCN; however, δ13C values for meteoritic aldehydes and ketones (Strecker precursors) have not yet been reported. As such, the distribution of aldehydes and ketones in the cosmos and their role in prebiotic reactions have not been fully investigated. Here, we have applied an optimized O‐(2,3,4,5,6‐pentafluorobenzyl)hydroxylamine (PFBHA) derivatization procedure to the extraction, identification, and δ13C analysis of carbonyl compounds in the Murchison meteorite. A suite of aldehydes and ketones, dominated by acetaldehyde, propionaldehyde, and acetone, were detected in the sample. δ13C values, ranging from −10.0‰ to +66.4‰, were more 13C‐depleted than would be expected for aldehydes and ketones derived from the interstellar medium, based on interstellar 12C/13C ratios. These relatively 13C‐depleted values suggest that chemical processes taking place in asteroid parent bodies (e.g., oxidation of the IOM) may provide a secondary source of aldehydes and ketones in the solar system. Comparisons between δ13C compositions of meteoritic aldehydes and ketones and other organic compound classes were used to evaluate potential structural relationships and associated reactions, including Strecker synthesis and alteration‐driven chemical pathways.
Campo del Cielo: A Campo by any other name
Authors: Wasson John T. 
Published: October 2018

AbstractA sample of Campo del Cielo with any other name would have the same composition. During the last three decades, our instrumental neutron activation analyses (INAA) of many supposedly new iron meteorites have shown an anomalously large fraction to have compositions within the compositional field of the IAB‐MG iron Campo del Cielo. A plot of Ir versus Au provides the best discrimination; only two independent‐fall irons found after 1980 with good recovery documentation fall within the 90% contour ellipse around the centroid of this Campo field, and one of these is from Antarctica. Now (early 2018) a total of 36 other irons attributed to other geographical locations have compositions that cannot be resolved from the Campo compositional field. Because it is possible that some of these are actually independent falls, the Meteoritical Society Nomenclature Committee has chosen to assign about half these meteorites Nova XXX names used for meteorites whose discovery localities are not adequately documented. However, for Campo‐like irons with too little information (e.g., total weight not known) or for which no adequately large type specimens are available, the decision is to call them Campos with the working name used during the UCLA analysis. In the UCLA Meteorite Collection, they are cataloged together with the documented Campos.
Rare, metal micrometeorites from the Indian Ocean
Authors: Shyam Prasad M. , Rudraswami N. G. , De Araujo Agnelo Alexandre , Khedekar V. D. 
Published: October 2018

AbstractMetal in various forms is common in almost all meteorites but considerably rare among micrometeorites. We report here the discovery of two metal micrometeorites, i.e., (1) an awaruite grain similar to those found in the metal nodules of CV chondrites and (2) a metal micrometeorite of kamacite composition enclosing inclusions of chromite and merrillite. This micrometeorite appears to be a fragment of H5/L5 chondrite. These metal micrometeorites add to the inventory of solar system materials that are accreted by the Earth in microscopic form. They also strengthen the argument that a large proportion of material accreted by the Earth that survives atmospheric entry is from asteroidal sources.
Competition between DivIVA and the nucleoid for ParA binding promotes segrosome separation and modulates mycobacterial cell elongation
Authors: Pióro Monika , Małecki Tomasz , Portas Magda , Magierowska Izabela , Trojanowski Damian , Sherratt David , Zakrzewska‐Czerwińska Jolanta , Ginda Katarzyna , Jakimowicz Dagmara 
Published: October 2018

SummaryAlthough mycobacteria are rod shaped and divide by simple binary fission, their cell cycle exhibits unusual features: unequal cell division producing daughter cells that elongate with different velocities, as well as asymmetric chromosome segregation and positioning throughout the cell cycle. As in other bacteria, mycobacterial chromosomes are segregated by pair of proteins, ParA and ParB. ParA is an ATPase that interacts with nucleoprotein ParB complexes – segrosomes and non‐specifically binds the nucleoid. Uniquely in mycobacteria, ParA interacts with a polar protein DivIVA (Wag31), responsible for asymmetric cell elongation, however the biological role of this interaction remained unknown. We hypothesised that this interaction plays a critical role in coordinating chromosome segregation with cell elongation. Using a set of ParA mutants, we determined that disruption of ParA‐DNA binding enhanced the interaction between ParA and DivIVA, indicating a competition between the nucleoid and DivIVA for ParA binding. Having identified the ParA mutation that disrupts its recruitment to DivIVA, we found that it led to inefficient segrosomes separation and increased the cell elongation rate. Our results suggest that ParA modulates DivIVA activity. Thus, we demonstrate that the ParA‐DivIVA interaction facilitates chromosome segregation and modulates cell elongation.
An RXLR effector secreted by Phytophthora parasitica is a virulence factor and triggers cell death in various plants
Authors: Huang Guiyan , Liu Zhirou , Gu Biao , Zhao Hong , Jia Jinbu , Fan Guangjin , Meng Yuling , Du Yu , Shan Weixing 
Published: October 2018

SummaryRXLR effectors encoded by Phytophthora species play a central role in pathogen–plant interactions. An understanding of the biological functions of RXLR effectors is conducive to the illumination of the pathogenic mechanisms and the development of disease control strategies. However, the virulence function of Phytophthora parasitica RXLR effectors is poorly understood. Here, we describe the identification of a P. parasitica RXLR effector gene, PPTG00121 (PpE4), which is highly transcribed during the early stages of infection. Live cell imaging of P. parasitica transformants expressing a full‐length PpE4 (E4FL)‐mCherry protein indicated that PpE4 is secreted and accumulates around haustoria during plant infection. Silencing of PpE4 in P. parasitica resulted in significantly reduced virulence on Nicotiana benthamiana. Transient expression of PpE4 in N. benthamiana in turn restored the pathogenicity of the PpE4‐silenced lines. Furthermore, the expression of PpE4 in both N. benthamiana and Arabidopsis thaliana consistently enhanced plant susceptibility to P. parasitica. These results indicate that PpE4 contributes to pathogen infection. Finally, heterologous expression experiments showed that PpE4 triggers non‐specific cell death in a variety of plants, including tobacco, tomato, potato and A. thaliana. Virus‐induced gene silencing assays revealed that PpE4‐induced cell death is dependent on HSP90, NPK and SGT1, suggesting that PpE4 is recognized by the plant immune system. In conclusion, PpE4 is an important virulence RXLR effector of P. parasitica and recognized by a wide range of host plants.
Fine‐tuning of RBOHF activity is achieved by differential phosphorylation and Ca2+ binding
Authors: Han Jian‐Pu , Köster Philipp , Drerup Maria M. , Scholz Martin , Li Shizhen , Edel Kai H. , Hashimoto Kenji , Kuchitsu Kazuyuki , Hippler Michael , Kudla Jörg 
Published: October 2018

Summary

RBOHF from Arabidopsis thaliana represents a multifunctional NADPH oxidase regulating biotic and abiotic stress tolerance, developmental processes and guard cell aperture. The molecular components and mechanisms determining RBOHF activity remain to be elucidated.

Here we combined protein interaction studies, biochemical and genetic approaches, and pathway reconstitution analyses to identify and characterize proteins that confer RBOHF regulation and elucidated mechanisms that adjust RBOHF activity.

While the Ca2+ sensor‐activated kinases CIPK11 and CIPK26 constitute alternative paths for RBOHF activation, the combined activity of CIPKs and the kinase open stomata 1 (OST1) triggers complementary activation of this NADPH oxidase, which is efficiently counteracted through dephosphorylation by the phosphatase ABI1. Within RBOHF, several distinct phosphorylation sites (p‐sites) in the N‐terminus of RBOHF appear to contribute individually to activity regulation.

These findings identify RBOHF as a convergence point targeted by a complex regulatory network of kinases and phosphatases. We propose that this allows for fine‐tuning of plant reactive oxygen species (ROS) production by RBOHF in response to different stimuli and in diverse physiological processes.
Improving the utilization of implantable cardioverter defibrillators for sudden cardiac arrest prevention (Improve SCA) in developing countries: Clinical characteristics and reasons for implantation refusal
Authors: Singh Balbir , Zhang Shu , Ching Chi‐Keong , Huang Dejia , Liu Yen‐Bin , Rodriguez Diego A. , Hussin Azlan , Kim Young‐Hoon , Chasnoits Alexandr Robertovich , Cerkvenik Jeffrey , Muckala Katy A. , Cheng Alan 
Published: October 2018

AbstractBackgroundDespite available evidence that implantable cardioverter defibrillators (ICDs) reduce all‐cause mortality among patients at risk for sudden cardiac death, utilization of ICDs is low especially in developing countries.ObjectiveTo summarize reasons for ICD or cardiac resynchronization therapy defibrillator implant refusal by patients at risk for sudden cardiac arrest (Improve SCA) in developing countries.MethodsPrimary prevention (PP) and secondary prevention (SP) patients from countries where ICD use is low were enrolled. PP patients with additional risk factors (syncope, ejection fraction < 25%, nonsustained ventricular tachycardia [NSVT], or frequent premature ventricular complexes) were further categorized as “1.5 PP patients.” Candidates who declined implantation were asked for reasons for refusal. Baseline factors that may have influenced the implant decision were examined using logistic regression.ResultsAmong 3892 patients, the implant refusal rate was 46.5% among PP patients (n = 2700), and 10.3% among SP patients (n = 1192). The most common refusal reason was inability to pay for the device (53.8%), followed by not believing in the benefits of the ICD (19.4%). Among PP ICD candidates, those with no syncope, no NSVT, no premature ventricular contractions, shorter QRS duration, no atrial arrhythmias, and no left bundle branch block were more likely to refuse implant. Among SP candidates, a history of cardiovascular surgery and no sinus node dysfunction were significant predictors of ICD refusal. Additionally, countries had significant differences in patient refusal rates among PP and SP groups.ConclusionImplant refusal among PP patients is high in many countries. Increased reimbursement and better awareness of the benefits of an ICD could increase their utilization.
Modeling leaf CO2 assimilation and Photosystem II photochemistry from chlorophyll fluorescence and the photochemical reflectance index
Authors: Hikosaka Kouki , Noda Hibiki M. 
Published: October 2018

AbstractWe present a simple model to assess the quantum yield of photochemistry (ΦP) and CO2 assimilation rate from two parameters that are detectable by remote sensing: chlorophyll (chl) fluorescence and the photochemical reflectance index (PRI). ΦP is expressed as a simple function of the chl fluorescence yield (ΦF) and nonphotochemical quenching (NPQ): ΦP = 1–bΦF(1 + NPQ). Because NPQ is known to be related with PRI, ΦP can be remotely assessed from solar‐induced fluorescence and the PRI. The CO2 assimilation rate can be assessed from the estimated ΦP value with either the maximum carboxylation rate (Vcmax), the intercellular CO2 concentration (Ci), or parameters of the stomatal conductance model. The model was applied to experimental data obtained for Chenopodium album leaves under various environmental conditions and was able to successfully predict ΦF values and the CO2 assimilation rate. The present model will improve the accuracy of assessments of gas exchange rates and primary productivity by remote sensing.
Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue
Authors: Zhang Amy J. , Boyd Anne H. , Asch Sarah , Warshaw Erin M. 
Published: October 2018

AbstractThe slime craze is all the rage among tweens. Slime is a homemade stretchy play material created by mixing together household items such as school glue, borax, shaving cream, and contact lens solution. We present a case of allergic contact dermatitis secondary to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in school glue used to make slime; mass spectroscopy confirmed MCI/MI in the patient's glue. Clinicians should be aware of slime as an emerging source of MCI/MI contact allergy.
Solitary plaque on the leg of a child: A report of two cases and a brief review of acral pseudolymphomatous angiokeratoma of children and unilesional mycosis fungoides
Authors: Evans Megan S. , Burkhart Craig N. , Bowers Edith V. , Culpepper Keliegh S. , Googe Paul B. , Magro Cynthia M. 
Published: October 2018

AbstractAcral pseudolymphomatous angiokeratoma of children (APACHE) and unilesional mycosis fungoides (MF) are two rare dermatoses in the pediatric population which may have overlapping clinical and histopathologic features, making differentiation between these two diagnoses difficult. We present two similar cases of a solitary plaque on the thigh of a child, one representing APACHE and the other representing unilesional MF with granulomatous features, and we provide a brief overview of the clinical and histopathologic features of APACHE and unilesional MF.
Multifocal congenital pyogenic granuloma successfully treated with oral propranolol
Authors: Alharbi Mana , Eber Ariel E. , Perper Marina , ALFalah Maisa , Al‐Khenaizan Sultan , Alomair Ibrahim A. , Alfuraih Abdulkareem , Nouri Keyvan , Cho‐Vega Jeong Hee 
Published: October 2018

AbstractDisseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT‐1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. We describe a case of DCPG effectively treated with propranolol.
Prescribing isotretinoin for transgender youth: A pledge for more inclusive care
Authors: Boos Markus D. , Ginsberg Brian A. , Peebles Jon Klint 
Published: October 2018

AbstractAs the transgender community has become increasingly visible in public life, a greater awareness of this group's unique health needs and obstacles to optimal medical care has developed. Unfortunately, transgender youth face multiple barriers within the health care system, including access to equitable and gender‐affirming care. As dermatologists who care for children and adolescents, we must be aware of the challenges facing transgender youth and work to correct the disparities that exist for this vulnerable group. An initial step in supporting our transgender patients is to advocate for changes to the iPLEDGE system for prescribing isotretinoin (and other Risk Evaluation and Mitigation Strategy systems), specifically requesting a change to its gender‐binary categorization model that compromises an individual's right to self‐identify. By promoting a gender‐neutral patient categorization that is based instead upon reproductive potential, a simple change to the iPLEDGE program allows us to safely treat all of our patients requiring isotretinoin, while preserving our transgender patients’ rights to self‐determination and self‐identification.