bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer patients’ perspectives on dignity in care
Authors: Bagherian Samaneh , Sharif Farkhondeh , Zarshenas Ladan , Torabizadeh Camellia , Abbaszadeh Abbas , Izadpanahi Payam 
Published: May 2019

Background: Since “dignity” is one of the fundamental rights of every patient, consideration for patients’ dignity is essential. Unfortunately, in many cases, especially in cancer patients, dignity is not fully respected. Dignity is an abstract concept, and there are only a few comprehensive studies on the dignity of cancer patients in Iran. Research objective: This study aimed to evaluate the perception of Iranian cancer patients on human dignity. Research design: A qualitative research approach was used as the study design. The data were collected through individual semi-structured interviews and analyzed using the qualitative content analysis method. Participants and research context: This study was conducted on cancer patients in internal medicine wards in Iran. The data were gathered through semi-structured interviews from May 2017 to February 2018. Ethical considerations: The study protocol was approved by the Research Ethics Committee of medical universities located in Southwest of Iran. The ethical principles were carefully followed throughout the study. Findings: Based on the results of the interviews, 3 main themes and 11 categories were determined. The main themes were identified as the “personal space and privacy,” “respect for human values,” and “moral support.” Discussion: The results of the present study showed the necessity of care for cancer patients in a respectful manner. The key elements in such care were the preservation of their personal space and privacy, respect for their values, and the provision of adequate moral support. These measures will have a positive effect on the perception of such patients on human dignity. Conclusion: Considering the special care required by cancer patients, the Iranian healthcare and hygiene managers should design and implement a care plan that includes the ethical principles related to human dignity.
Early versus late switch: How long should we extend the anti-vascular endothelial growth factor therapy in unresponsive diabetic macular edema patients?
Authors: Hernández Martínez Adrian , Pereira Delgado Ernesto , Silva Silva Guillermo , Castellanos Mateos Luis , Lorente Pascual José , Lainez Villa Julian , García Vicente Paula , Almeida-González Carmen-Victoria 
Published: May 2019

Purpose: To compare the results of early versus late switch to the dexamethasone intravitreal implant Ozurdex® in patients with diabetic macular edema who had a poor response to vascular endothelial growth factor inhibitors. Methods: Retrospective and single-center study conducted, in a real setting, on consecutive diabetic macular edema patients who were switch to an intravitreal dexamethasone implant after a poor response to anti-vascular endothelial growth factor treatment. Study sample was divided into two groups: (1) early-switch group, included those eyes who received three anti-vascular endothelial growth factor injections before switch and (2) late-switch group, included those eyes that received six or more anti-vascular endothelial growth factor injections before switch. The primary end-point was the difference in mean change in best-corrected visual acuity and in central subfoveal thickness. Results: A total of 69 (31 early-switch group and 38 late-switch group) eyes were included. In the early-switch group, median (25–75 quartile range) best-corrected visual acuity significantly increase from 0.2 (0.2–0.5) at baseline to 0.4 (0.3 –0.7) at month 24 (p = 0.0043). Whereas, in the late-switch group, best-corrected visual acuity did not increase (p = 0.8602). Central subfoveal thickness was significantly reduced in both early- and late-switch groups, p = 0.0002 and 0.0038, respectively. The proportion of eyes obtaining a central subfoveal thickness reduction ⩾ 10% was significantly greater in the early-switch group than in the late-switch group (71.0% vs 47.4%, respectively, p = 0.0498). Three (9.7%) and 10 (26.3%) eyes have developed ocular hypertension during the study in the early- and late-switch groups, respectively, p = 0.0816. Conclusion: Early switch to Ozurdex in patients who did not adequately respond to anti-vascular endothelial growth factor therapy provided better functional and anatomical outcomes.
Corneal sterile infiltration induced by topical use of ocular hypotensive agent
Authors: Manabe Yusuke , Sawada Akira , Mochizuki Kiyofumi 
Published: May 2019

Purpose: To report two cases with corneal sterile infiltration presumably due to topical ocular hypotensive agent. Method: Case report. Results: Case 1: A 65-year-old man presented with corneal opacity and neovascularization in his left eye. A diagnosis of glaucoma was made 2 years previously, and anti-glaucoma agents were prescribed (brimonidine tartrate, ripasudil hydrochloride hydrate, and brinzolamide) for both eyes. Case 2: A 75-year-old woman noticed corneal opacity in the left eye. A diagnosis of glaucoma was made 35 years previously, and anti-glaucoma agents were prescribed (brimonidine tartrate, 1% dorzolamide, and bimatoprost) for both eyes. In both cases, ocular examination revealed follicular conjunctivitis and blepharitis in both eyes, and corneal sterile infiltration with neovascularization in the left eyes. The three topical drugs were discontinued and replaced with 0.1% fluorometholone. Both the blepharitis and corneal sterile infiltration improved thereafter, although corneal opacity remained across the stromal layer. Conclusion: We encountered two cases of corneal and conjunctival complications that were suspected as side effects after brimonidine eye drop use. Special care should be taken to observe the condition of ocular surface when topical brimonidine is administered.
HN Cementless HIP System. Results on 320 Cases with Average 2 Years Follow-Up
Authors: Henry F. , Negre J. 
Published: May 2019

The study of any cementless hip system is essentially based on three concepts: initial stability, secondary biological stability and factors regarding the reliability of this stability. Initial Stability relies on optimal bone fill with press-fit support on the cortical bone. For the acetabular component, this is best achieved with a hemispherical form. Femoral support is assured by a triple cortical contact in the metaphyseal zone. A triple support requires a stem with a sagittal bow. Secondary stability must account for a compromise between fixation and extractability. The sand-blasted titanium surface provides this possibility. Bone on-growth produces a sheath around the metal, similar to cement, from the fourth week onwards. Reliability. Reliabe stability of the a cetabular cup is favored by the hemispherical form of the s hell and the ample thickness of polyethylene which distribute adverse forces. Femur stability is provided through pure metaphyseal fixation. Metaphysodiaphyseal fixation often becomes plain diaphyseal fixation with all its inherent problems. Initial results with a minimum follow-up of one year (320 cases with an average follow-up of 2 years) seem to confirm the efficient nature of the biological fixation by the total absence of pain. Only the future will tell us if our concepts are entirely effective.
The Porous-Coated Anatomic (PCA) Total Hip Prosthesis
Authors: Farsetti P. , Caterini R. , Barletta V. , Guarnieri A. E. , Ippolito E. 
Published: May 2019

Thirty uncemented porous-coated anatomic (PCA) total hip prostheses were implanted in 27 patients. The average age at the time of surgery was 54 years, and the average follow-up was 4.5 years. The average hip rating score was 88 points. Three patients had thigh pain at follow-up and fifteen had a mild limp, related to a weakness of the gluteus medius and minimus. On radiographic examination, we observed a good bone ingrowth of the implant in all patients. No aseptic loosening was radiographically demonstrated. No relationship was found between pain in the thigh and the various radiographic parameters studied (ra-diodense lines, sclerosis, varus position of the stem).
Feasibility of ultra-low radiation dose digital subtraction angiography: Preliminary study in a simplified cerebral angiography phantom
Authors: Maeng Jun Young , Song Yunsun , Sung Yu Sub , Kim Tae-Il , Lee Deok Hee , Kim Tae-Hyung 
Published: May 2019

Introduction The objective of this article is to evaluate the feasibility of cerebral digital subtraction angiography (DSA) using ultra-low radiation dose settings in a simplified cerebral angiography phantom. Materials and methods We created a silicone phantom capable of producing a simplified cerebral DSA. A total of 18 DSA sets were obtained with gradual six-step reduction of the detector entrance dose (DED) from 1.82 to 0.08 μGy per frame, while standard, postprocessing algorithm (PPA) and copper filter (0.3 mm) with PPA (CwP) algorithm reconstruction protocols were applied. We quantitatively compared their signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and qualitatively analyzed the images' qualities in terms of image sharpness, contrast, and noise as investigated by five observers. Results The SNR and CNR, which decreased with lowering of the DED in the standard protocol group, were significantly compensated by using the PPA. The values were approximately double in the PPA (11.5 ± 2.9) and CwP (11.0 ± 2.5) groups compared with the standard (5.4 ± 1.1) group in the DED of 0.24 μGy per frame as well as in the other values. The total scores of the observers according to the protocols showed a tendency to decrease as the DED lowered. On average, the PPA (96.3 ± 34.6) and CwP (91.3 ± 29.9) groups yielded higher results than the standard protocol (83.7 ± 46.7). Conclusion Given that the current DED ranges from 1.82 to 3.60 μGy per frame for routine cerebral DSA, our results indicate that DED can be decreased to 15%–30% of the current dose level in vessels 2–4 mm in diameter if image-improvement algorithms are applied.
Health‐related quality of life in inflammatory bowel disease in a Danish population‐based inception cohort
Authors: Christiansen Lea K , Lo Bobby , Bendtsen Flemming , Vind Ida , Vester-Andersen Marianne K , Burisch Johan 
Published: May 2019

BackgroundCrohn's disease (CD) and ulcerative colitis (UC) are associated with reduced health‐related quality of life (HRQoL), but findings differ between studies. The aim of this study was to analyse the impact of disease activity and social factors on HRQoL.MethodA total of 513 patients diagnosed with UC and CD between 2003 and 2004, in a population‐based setting, were followed for 7 years. HRQoL was assessed using the Short Form‐12, the Short Inflammatory Bowel Disease (IBD) Questionnaire (SIBDQ), the Work Productivity and Activity Impairment Questionnaire: General Health and a national health survey. Associations were assessed using multiple linear regressions.ResultsA total of 185 of the eligible patients (UC: 107 (50.2%) and CD: 78 (50.3%)) were included. No differences in disease‐specific or generic HRQoL were found between CD and UC patients, and IBD patients did not differ compared with the background population. The majority of CD (73.1%) and UC (85.0%) patients had ‘good’ disease‐specific HRQoL using the SIBDQ. Unemployment for ≥ 3 months occurred more in CD vs UC patients(30.6 vs 15.5%, p = 0.03); however, sick leave for ≥ 3 months did not differ significantly (17.4 vs 11.4%, p = 0.4). Using multiple linear regressions, unemployment, sick leave and disease activity were the factors most frequently associated with reduced HRQoL.ConclusionIn a population‐based cohort with 7 years of follow‐up, HRQoL did not differ between patients and the background population.
A retrospective comparison of venetoclax alone or in combination with an anti-CD20 monoclonal antibody in R/R CLL
Authors: Mato Anthony R. , Roeker Lindsey E. , Eyre Toby A. , Nabhan Chadi , Lamanna Nicole , Hill Brian T. , Brander Danielle M. , Barr Paul M. , Lansigan Frederick , Cheson Bruce D. , Singavi Arun K. , Yazdy Maryam Sarraf , Shah Nirav N. , Allan John N. , Bhavsar Erica B. , Rhodes Joanna , Kennard Kaitlin , Schuster Stephen J. , Williams AnnaLynn M. , Skarbnik Alan P. , Goy Andre H. , Goodfriend Julie M. , Dorsey Colleen , Coombs Catherine C. , Tuncer Hande , Ujjani Chaitra S. , Jacobs Ryan , Winter Allison M. , Pagel John M. , Bailey Neil , Schuh Anna , Shadman Mazyar , Sitlinger Andrea , Weissbrot Hanna , Muralikrishnan Sivraj , Zelenetz Andrew , Kirkwood Amy A. , Fox Christopher P. 
Published: May 2019

AbstractVenetoclax (VEN) is approved for relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) as monotherapy (VENmono) or in combination with rituximab. Whether VEN plus anti-CD20 (VENcombo) is superior to VENmono is unknown. We conducted a multicenter, retrospective cohort analysis comparing 321 CLL patients treated with VENmono vs VENcombo across the United States and the United Kingdom. We examined demographics, baseline characteristics, dosing, adverse events, response rates, and outcomes. The primary endpoints were progression-free survival (PFS) and overall survival (OS), estimated by Kaplan-Meier method, in patients treated with VENmono vs VENcombo. Univariate and bivariate analyses were performed with COX regression. Three hundred twenty-one CLL patients were included (3 median prior treatments, 78% prior ibrutinib). The overall response rates (ORRs) were similar (VENmono, 81% ORR, 34% complete remission [CR] vs VENcombo, 84% ORR, 32% CR). With a median follow-up of 13.4 months, no differences in PFS and OS were observed between the groups. In unadjusted analyses, the hazard ratios (HRs) for PFS and OS for VENmono vs VENcombo were HR 1.0 (95% confidence interval [CI], 0.6-1.8; P = .7) and HR 1.2 (95% CI, 0.6-2.3; P = .5), respectively. When adjusting for differences between the cohorts, the addition of an anti-CD20 antibody in combination with VEN did not impact PFS (HR, 1.0; 95% CI, 0.5-2.0; P = .9) or OS (HR, 1.1; 95% CI, 0.4-2.6; P = .8). We demonstrate comparable efficacy between VENmono and VENcombo in a heavily pretreated, high-risk, retrospective cohort, in terms of both response data and survival outcomes. Prospective studies are needed to validate these findings.
Solvent-mediated extraction of fatty acids in bilayer oil paint models: a comparative analysis of solvent application methods
Authors: Baij Lambert , Astefanei Alina , Hermans Joen , Brinkhuis Francine , Groenewegen Heleen , Chassouant Louise , Johansson Sofia , Corthals Garry , Tokarski Caroline , Iedema Piet , Keune Katrien 
Published: May 2019

Abstract
The impact of solvent exposure on oil paintings and the differences between solvent application methods are longstanding topics in cleaning studies. Solvent exposure is ideally kept to a minimum, because solvent swelling can lead to the extraction and displacement of reactive paint components. In particular, important concerns are fatty acids displacement resulting in metal soap formation and embrittlement of paint due to solvent exposure. In this study, the extraction of a saturated fatty acid (SFA) marker and the formation of zinc soaps were monitored to measure the impact of solvent cleaning on tailored bilayer model systems for aged oil paint. Three methods of solvent application were compared: cotton swab, rigid gel and Evolon tissue (with different solvent loading). The samples were analysed by surface acoustic wave nebulization mass spectrometry (SAWN-MS) and thermally-assisted hydrolysis and methylation pyrolysis gas chromatography mass spectrometry (THM-Py-GC/MS) by comparing the calculated margaric:palmitic acid (

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17

:

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16

) ratio determined in the extracts (taken from the swab, gel or Evolon tissue). We conclude that both swab cleaning and squeezed Evolon tissue application result in comparable SFA extraction. The rigid gel and Evolon with controlled solvent-loading limit the amount of SFA extraction. The distribution of

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17

after solvent application was visualised using static Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) on cross sections, showing that

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17

redistribution took place in all cases where solvent was applied. Crystalline zinc soaps formation was not observed after 5 min of ethanol exposure in the embedded cross-sections with imaging ATR-FTIR, indicating that solvent exposure does not immediately trigger the formation of crystalline metal soaps. However, significant zinc soap formation was found after 30 min of ethanol exposure using Evolon tissue without controlled loading. This study contributes to a better understanding of the impact of different methods of solvent application on oil paintings and highlights important differences between these methods.
Clinician Report of Oral Oncolytic Symptoms and Adherence Obtained via a Patient-Reported Outcome Measure (PROM)
Authors: Nachar Victoria R. , Farris Karen , Beekman Katie , Griggs Jennifer , Hough Shannon , Mackler Emily 
Published: May 2019

PURPOSE Patient-reported outcome measures (PROMs) for symptom monitoring during cancer therapy have been shown to have a positive impact on outcomes. These findings have primarily been shown for patients receiving intravenous chemotherapy. In addition, there is known discordance between physician reporting of symptoms and patient self-report. This initiative sought to describe patient-reported symptom burden and medication adherence and to indicate the degree of PROM results being discussed with the provider as indicated by documentation in the medical record for patients taking oral oncolytic therapy. METHODS The Michigan Oncology Quality Consortium (MOQC) PROM, which included symptom ratings, medication adherence, and patient confidence in self-management, was completed during outpatient visits and compared with corresponding data documented in the electronic medical record (EMR). RESULTS There were 82 completed PROMs. Approximately half included at least one symptom rated as severe (46%). Sixty-five percent of reported severe symptoms were documented in the EMR. Patient-reported moderate-to-severe pain was most likely to be documented in the EMR (100%), whereas patient-reported moderate-to-severe depression and anxiety were least likely to be documented (21%). Of the total symptoms documented, grading of symptom severity matched that of the patients’ own report for 11% of severe symptoms. Adherence to oral oncolytics was excellent for 63% of patients, and patient adherence was documented in 7% of provider notes. CONCLUSION Patients frequently reported moderate-to-severe symptoms, and approximately 40% of patients reported nonadherence. Clinician report (documented in the EMR) of the patient symptom burden, symptom severity, and adherence to oral oncolytic therapy was not consistent with the patients’ self-report. Use of a PROM for patients taking oral oncolytics has the opportunity to improve symptom management and medication adherence.
Perceptions of Patients With Breast and Colon Cancer of the Management of Cancer-Related Pain, Fatigue, and Emotional Distress in Community Oncology
Authors: Smith Tenbroeck G. , Troeschel Alyssa N. , Castro Kathleen M. , Arora Neeraj K. , Stein Kevin , Lipscomb Joseph , Brawley Otis W. , McCabe Ryan M. , Clauser Steven B. , Ward Elizabeth 
Published: May 2019

PURPOSE Pain, fatigue, and distress are common among patients with cancer but are often underassessed and undertreated. We examine the prevalence of pain, fatigue, and emotional distress among patients with cancer, as well as patient perceptions of the symptom care they received. PATIENTS AND METHODS Seventeen Commission on Cancer–accredited cancer centers across the United States sampled patients with local/regional breast (82%) or colon (18%) cancer. We received 2,487 completed surveys (61% response rate). RESULTS Of patients, 76%, 78%, and 59% reported talking to a clinician about pain, fatigue, and distress, respectively, and 70%, 61%, and 54% reported receiving advice. Sixty-one percent of patients experienced pain, 74% fatigue, and 46% distress. Among those patients experiencing each symptom, 58% reported getting the help they wanted for pain, 40% for fatigue, and 45% for distress. Multilevel logistic regression models revealed that patients experiencing symptoms were significantly more likely to have talked about and received advice on coping with these symptoms. In addition, patients who were receiving or recently completed curative treatment reported more symptoms and better symptom care than did those who were further in time from curative treatment. CONCLUSION In our sample, 30% to 50% of patients with cancer in community cancer centers did not report discussing, getting advice, or receiving desired help for pain, fatigue, or emotional distress. This finding suggests that there is room for improvement in the management of these three common cancer-related symptoms. Higher proportions of talk and advice among those experiencing symptoms imply that many discussions may be patient initiated. Lower rates of talk and advice among those who are further in time from treatment suggest the need for more assessment among longer-term survivors, many of whom continue to experience these symptoms. These findings seem to be especially important given the high prevalence of these symptoms in our sample.
Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis
Authors: Vanherp Liesbeth , Ristani Alexandra , Poelmans Jennifer , Hillen Amy , Lagrou Katrien , Janbon Guilhem , Brock Matthias , Himmelreich Uwe , Vande Velde Greetje 
Published: May 2019

ABSTRACT
Cryptococcus neoformans is a leading cause of fungal brain infection, but the mechanism of dissemination and dynamics of cerebral infection following pulmonary disease are poorly understood. To address these questions, non-invasive techniques that can study the dynamic processes of disease development and progression in living animal models or patients are required. As such, bioluminescence imaging (BLI) has emerged as a powerful tool to evaluate the spatial and temporal distribution of infection in living animals. We aimed to study the time profile of the dissemination of cryptococcosis from the lung to the brain in murine models by engineering the first bioluminescent C. neoformans KN99α strain, expressing a sequence-optimized red-shifted luciferase. The high pathogen specificity and sensitivity of BLI was complemented by the three-dimensional anatomical information from micro-computed tomography (μCT) of the lung and magnetic resonance imaging (MRI) of the brain. These non-invasive imaging techniques provided longitudinal readouts on the spatial and temporal distribution of infection following intravenous, intranasal or endotracheal routes of inoculation. Furthermore, the imaging results correlated strongly with the fungal load in the respective organs. By obtaining dynamic and quantitative information about the extent and timing of brain infections for individual animals, we found that dissemination to the brain after primary infection of the lung is likely a late-stage event with a timeframe that is variable between animals. This novel tool in Cryptococcus research can aid the identification of host and pathogen factors involved in this process, and supports development of novel preventive or therapeutic approaches.