bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Numerical Evaluation of Spontaneous Imbibition Processes in Unfractured and Fractured Carbonate Cores with Stress-Induced Apertures
Authors: Vilhena Odilla , Farzaneh Amir , Pola Jackson , March Rafael , Sisson Adam , Sohrabi Mehran 
Published: June 2019

Abstract
Spontaneous imbibition (SI) experiments in fractured and unfractured Indiana limestone cores were performed to evaluate the impact of fractures in oil recovery. Numerical simulations were run to reproduce the experimental setting and history match fracture and matrix properties. Tracer tests were carried out to investigate the effect of changing stresses in the hydraulic fracture conductivity. The pore space and connected pores in the fractured plug were analysed via Micro-CT scan and thin petrography analysis was carried out to observe the matrix heterogeneity of the samples. Relative permeability, capillary pressure and fracture properties were estimated numerically for Indiana limestone carbonate rocks to match the SI curves measured at a temperature of 58.7° C. The investigation shows that the fractured core has suffered a deformation under stress conditions impacting the initial values of fracture aperture and permeability. This deformation has led to decreased flow rates in the fracture and oil trapping in the fracture channel. At the field scale, this phenomenon could lead to decreased oil recovery in the first days of production.
Factors Affecting the False Negative of Cryptococcal antigen in Patients with Cryptococcosis: Immunology and Radiology
Authors: Min jingqi , Huang kunlun , Shi chanmei , Li laifu , Zhu Tao , Deng huojin 
Published: June 2019

Abstract
Study objectives

The purpose of this article is to investigate the factors associated with false negatives in cryptococcal antigen detection in patients with pulmonary cryptococcosis by studying the effects of immune status and radiology on cryptococcal antigen results.

Methods

The clinical records, serum cryptococcal antigen result, laboratory findings and computed tomography findings of 61 immunocompetent and 17 immunocompromised patients with a diagnosis based on biopsy confirmation of the presence of pulmonary cryptococcosis were reviewed during the course of the study. Chi-square test was used to analyze categorical variable. The independent t-test was obtained to analyze continuous variable. Logistic regression models was used to analyze the effects of immunity and radiology imaging on cryptococcal antigen results.

Results

We studied the differences between these two groups. No difference were found in baseline characteristics, clinical symptoms, and laboratory findings. Logistic regression analysis showed that the significant independent variables related to serum cryptococcal antigen result were the immune status and radiology findings.

Conclusions

Our study indicates that immune status and lung imaging findings are important factors influencing cryptococcal antigen detection.
Impact of intestinal helminthes infections on stunting, wasting, normal biochemical and hematological values on school children in Gondar town, Ethiopia.
Authors: Lemma Wossenseged , Tarekegn Daniel , Birhanie Meseret 
Published: June 2019

Abstract
Abstract
Background: Ethiopia, the second populous nation in Africa, has been grouped under low income countries. Stunting, underweight and wasting in school children in Ethiopia are very common. The aim of this research was to evaluate the nutritional status compared to WHO standards and impact of intestinal helminthes on normal growth, normal hematological and biochemical values in the school children in Azezo Elementary School in Gondar Town.
Methods: Demographic data and information about possible risk factors were obtained using standard pre-tested questioners for all study subjects. WHO AnthroPlus software version 1.04 (WHO, Geneva, Switzerland) were used to classify school children as normal, stunted, wasted and obese after height and body weight measurements were obtained. The Kato Katz technique was performed to screen students for intestinalhelmenthinfections and calculate eggs per gram stool (epg). Haematological and biochemical normal values were obtained from hematology fully-automated cell counter (Mindray BC-3200) and Mindray BS-200E chemistry analyzer.
Results: Atotal of 384 school children with age ranged from 7 to 15 years old were recruited in this study. Of the total school children analysed for body mass index and height for age Z scores (BAZ and HAZ scores), 103 (26.8%) were wasted (Z scores < -2SD) and 47 (12.2%) stunted (< -2SD). Gender showed no statistically significantly differences (p>0.05) for BAZ and HAZ. The prevalence of overall stunting in 7-10 age group was 0.7% (1/146) compared to 19.5% (46/236) in 11-15 age group (p=0.000). Intestinal helminthes infections were statistically significantly associated (p = 0.000) with hypo-gycocemia, hypo-proteinaemia and anemia compared with non-infected school children. The likelihood of anemia in intestinal helminth infected school children, when it was compared with uninfected was 148 times higher for both Ascarislumbericoides-Schistosomamansoni co-infection, 38 times for Hook worm, 20 times for Schistosomamansoni and 3 times for Ascarislumbericoidesmono-infection.
Conclusion: Malnutrition and intestinal helminthes infections are serious problem in normal growth of the school children. Poverty associated malnutrition is the most important risk factor for stunting.
Key Words: School children; Malnutrition; Intestinal Helminth infections; Nutritional status ; Gondar town
Shift in New HIV/AIDS Epidemic and Factors Associated with False Positives for HIV Testing: A Retrospective Study from 2013 to 2018 in Xi’an, China
Authors: Wang Jing-Yuan , Zhang Kai-Ge , Ruan Jin-xiong , Chen Wei , Wang Linchuan 
Published: June 2019

Abstract
Objectives: In the study, firstly, the epidemic characteristics of new HIV/AIDS were investigated in order to provide evidence for the targeted interventions; Secondly, the major factors of false positives (FP) for HIV testing were also determined.
Methods: A retrospective review was performed in a teaching hospital in Xi’an between 2013 and 2018. The overall characteristics and epidemiological trends of new HIV/AIDS were described. Moreover, the distributions of FP cases in the gender, age and department were analysed, and the major factors of FP were determined by the Pareto analysis.
Results: During the study, a total of 469 new HIV/AIDS were diagnosed, with an increasing prevalence from 0.0626% in 2013 to 0.0827% in 2018. Of them, the majority occurred in the Hans (99.57%), males (88.50%), people aged 21-50 years (76.97%), migrants (60.98%) and sexual contact route (88.70%). A rapid increase in the annual number of new HIV/AIDS and multiple routes of HIV transmission were found. The epidemic showed increasing trends in groups of young individuals, students and homosexual mode, however, a downward trend in the percentage of injecting drug use was also observed. 67.81% of FP cases were over 50 years old. The departments of oncology, obstetrics, hepatobiliary surgery, nephrology, cardiology and infectious disease were major factors of FP by Pareto analysis.
Conclusions: The HIV/AIDS epidemic in Xi’an is still evolving, therefore, effective strategies, appropriate education and scaling up HIV testing should be developed to control the spread of the epidemic. In addition, old adults and specific departments were associated with FP.
New records of Digitaria filiformis var. laeviglumis (Paniceae, Panicoideae, Poaceae) for the Flora del Bajío and Durango, Mexico
Authors: Sánchez Ken Jorge Gabriel 
Published: June 2019

Background and Aims: Since its publication in 1920, Digitaria filiformis var. laeviglumis had been considered as an endangered taxon endemic to New Hampshire, USA. However, a recent inventory of the grasses of Mexico showed that it also occurs outside its type locality. New findings for the ongoing project Flora del Bajío have yielded additional new records. The objective of this work is to report this taxon from the Mexican states of Michoacán and Durango, increasing the number of known localities of Digitaria filiformis var. laeviglumis.Methods: Online databases and herbaria were reviewed. Botanical herbarium specimens were collected in the state of Michoacán.Key results: Digitaria filiformis var. laeviglumis is reported as new for the Flora del Bajío in the state of Michoacán, as well as from a herbarium specimen from Durango which has both var. laeviglumis and var. filiformis mounted on the same sheet and that was misplaced among other specimens.Conclusions: With the addition of this variety, the number of taxa in the subfamily Panicoideae increases for the Flora del Bajío and the state Durango. With these findings there are more intermediate localities between the northern and southern range for this variety.
Evaluation of eMentalHealth.ca, a Canadian Mental Health Website Portal: Mixed Methods Assessment
Authors: Jeong Dahn , Cheng Michael , St-Jean Mireille , Jalali Alireza 
Published: June 2019

Background
Many Canadians have mental health needs, and it can be challenging not knowing where to go for mental health information, services, and support. The website eMentalHealth.ca was created to facilitate and assist Canadians to (1) learn about mental health, (2) screen for common mental health issues, and (3) find mental health services and support.

Objective
The aim of this study was to use multiple methods to learn about visitors of eMentalHealth.ca, their perceptions, and their satisfaction with the website.

Methods
Website analytics (Google Analytics) provided information about the number of unique visits to the website and how the site was used. Web-based self-administered surveys were used to gather additional information on users’ characteristics and to assess their perception of the website and satisfaction with the website.

Results
Web analytic results showed that from January 1 to December 31, 2017, there were 651,107 users, with 1.97 million page views. Users were more often female than male, and the majority of users were aged 35 years and older. Most users were located in Canada (612,806/651,107, 94.12%), and the most common city of origin of users was Toronto (101,473/651,107, 15.58%), followed by Ottawa (76,692/651,107, 11.78%), and Montreal (26,621/651,107, 4.09%). Web-based surveys were completed by a total of 370 respondents from June to December 2017. Overall, the majority of users were satisfied with the website (93.0%, 320 out of 344 responses). Positive feedback was related to the content of the website as a helpful resource, and negative feedback was related to technical difficulties as well as the design of the main page. This analysis will be used to help the team with ongoing improvements to the website, for example, improving technical issues and homepage usability.

Conclusions
Most visitors reported satisfaction with their use of eMentalHealth.ca to learn about mental health as well as where to find help. Mental health websites such as eMentalHealth.ca are a low-cost way to increase public awareness about mental health.
EVALUATION OF PRESCRIBING INDICATORS FOR PEADIATRIC OUTPATIENTS UNDER SIX YEARS OLD IN DISTRICT HOSPITALS OF CAN THO CITY IN THE PERIOD OF 2015-2016
Authors: Nguyen Hung Phuc , MY HUONG VO THI , CHI THANH PHAN 
Published: June 2019

Objective: Examining and comparing the primary and supplementary prescribing indicators in pediatric outpatients under six years old.
Methods: We performed a comparative cross-sectional study, over nine months, from September 2015. 800 prescriptions for peadiatric patients under 6 y old were collected at 8 district hospitals in Can Tho city to evaluate the primary and supplementary prescribing indicators. The sample was collected prospectively by the systematic selection, with the interval between the patients is 5. The data was analysed and compared to the standard drug use indicators in developing countries recommended by WHO.
Results: Average number of drugs per encounter: 4.1, percentage of drugs prescribed by generic name: 94.2%, percentage of encounters with an antibiotic prescribed: 85.8%, percentage of drugs prescribed from essential drugs list by Ministry of Health: 78.7%, percentage of encounters with a corticoid prescribed: 41.7%, percentage of encounters with a vitamin prescribed: 13.1%, average drug cost per encounter: 37.5 thousands VND, percentage of drug costs spent on antibiotics: 55.2%, percentage of drug costs spent on essential drugs: 75.7%, percentage of drug costs spent on corticoid: 1.9%, percentage of drug costs spent on vitamin: 1.4%.
Conclusion: The results of this research have identified some issues in outpatient prescribing, which may lead to intervention studies for evaluating changes in these issues in the outpatient clinic.
ASSESSMENT OF GESTATIONAL DIABETES MELLITUS RELATED STRESS USING A SPECIFIC SCALE ADMINISTERED AS AN ONLINE MOBILE APPLICATION
Authors: SRINIVASAN A. , KRISHNARAJAN D. , SARANYA P. , JITHIN T. G. , THOMAS SNEHA , VARADHARAJAN V. 
Published: June 2019

Objective: Aim of the study was to assess the Gestational Diabetes Mellitus (GDM) related stress among pregnant women using an online mobile application based specific stress scale for GDM.
Methods: This was a prospective observational study. All GDM patients who have used the Gestational Diabetes Stress Scale (GDSS)-mobile application within the study period were included (176 patients). Their total and subscale stress scores were analyzed.
Results: This study found that 52.84% of the total population needed clinical attention for GDM related stress. The subscale scores revealed that 65.91% of the population needed clinical attention for emotional burden, 15.34% of the population needed clinical attention for medication-related stress, 69.89% of the population needed clinical attention for social or economical stress and 36.36% of the population needed clinical attention for health care set up related stress.
Conclusion: Based upon this study we conclude that GDSS is a good invention. There existed a gap in measuring GDM related stress in pregnant women and GDSS is a solution for the same.
NEUROPROTECTIVE EFFECT OF CITRULLUS LANATUS SEED EXTRACTS ON CEREBRAL ISCHEMIC REPERFUSION INJURY INDUCED COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS
Authors: Pashikanti Girija , AJITHA MAKULA , PUCHCHAKAYALA GOVERDHAN 
Published: June 2019

Objective: Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease (AD). The present study was designed to investigate the neuroprotective effects of citrullus lanatus on bilateral common carotid artery occlusion (BCCAO) induced cognitive impairment and oxidative stress in Wistar albino rats.
Methods: Cognitive impairment and oxidative stress were induced by BCCAO for 30 min, followed by 7 d reperfusion of male wistar rats. Morris water maze and rectangular maze performance tests and locomotor activity were used to assess memory performance tasks. To study the activity, rats weighing 250-300g were pre-treated with successive extracts of n-hexane fraction (HF), ethyl acetate fraction (EAF), ethanol fraction (EF) and aqueous fraction (AF) of 400 mg/kg, 200 mg/kg, p. o of each for 10 d and the treatment was continued for another 7 d after cerebral ischemia. Various biochemical parameters like lipid peroxidation, Catalase, DPPH and AchE were also estimated in the brain after the treatment.
Results: There was significantly increased oxidative stress and cholinesterase activity with cognitive decline in the hippocampus in rats of BCCAO group as compared to sham-operated (p<0.05). The animals treated with Donepezil, HF and EF prevented the biochemical changes significantly (p<0.001) and there was significant (p<0.001) improvement in cognitive parameters compared to BCCAO treated rats.
Conclusion: Thus present study indicates the neuroprotective effect of citrulus lanatus seed extract (HF and EF) against BCCAO induced cognitive impairment and associative oxidative damage.
Effects of mindfulness-based interventions on quality of life of women with breast cancer: a systematic review
Authors: Zhang Xinyan , Liu Dongling , Li Yuxiang , Zhang Ye , Zhang Bingyan , Wang Xiuli , Wang Guijie 
Published: June 2019

Aim:
The systematic review assessed the effect of mindfulness-based interventions on the quality of life among women with breast cancer.
Methods:
PubMed, Cochrane library, EMBASE, Web of Science and CINAHL databases were searched for studies published. Our review assessed the effect of mindfulness-based interventions (Mindfulness-Based Stress Reduction [MBSR] intervention and Mindfulness-Based Cognitive Therapy [MBCT]) on quality of life for women with breast cancer. Two authors independently assessed the quality of all included studies using the Downs and Black Quality Index.
Results:
The search finally identified 15 studies. The MBSR intervention showed a significant effect between groups. The MBCT intervention also showed good effect on quality of life. Adverse events were inadequately reported.
Conclusion:
The MBSR intervention on quality of life among women with breast cancer was effective and safe. The effect of MBCT intervention on quality of life still needs more research.
Breve perspectiva historiográfica sobre a ancestralidade da etnia indígena Kaingang
Authors: Gaudêncio Jéssica Da Silva , Martins Décio Ruivo , Silveira Rosemari Monteiro Castilho Foggiatto , Rodrigues Sérgio Paulo Jorge 
Published: June 2019

O objetivo deste artigo é apresentar a historiografia da ancestralidade da etnia indígena conhecida hoje como Kaingang. Antes do século XX, os ancestrais desta etnia foram retratados e citados em várias obras por diversos nomes; porém, nem todos os grupos indígenas referidos na documentação histórica eram Kaingang, o que pode ser verificado pelas características culturais presentes nas documentações de origem. Essa multiplicidade de denominações, além das observações em diferentes regiões geográficas sobre a presença de grupos étnicos com características semelhantes às pertencentes à etnia Kaingang, pode induzir interpretações equivocadas e erradas por pesquisadores. Muitos autores consideram o grupo indígena identificado como Guaianá na literatura da época colonial como os ancestrais da etnia Kaingang. Com base nas pesquisas e em estudos sustentados pelas restritas evidências documentais dos séculos passados, pode-se considerar essa ancestralidade; entretanto, conclui-se que há necessidade de estudos etnográficos com maiores detalhes, para que se possa evidenciar essa proximidade étnica.
100-LB: Blood Glucose Forecasting with Extended Prediction Horizon
Authors: COLBURN DAVID , ROUDSARI VIRA BEHNAM , GANDICA RACHELLE , SIA SAMUEL 
Published: June 2019

Accurate forecast of blood glucose levels could predict the onset of hypo- or hyperglycemic events and provide actionable information to patients, thereby improving glycemic variability and time in range, two important metrics for managing diabetes and assessing clinical outcomes. Current commercial continuous glucose monitors (CGMs) offer glucose trend prediction, but these predictions are often inaccurate. We hypothesize that the limited performance and utility of these predictive algorithms is likely due to using only glucose as the explanatory variable. By accounting for additional relevant features, we aim to build an algorithm that accurately predicts glucose levels with a prediction horizon of 1 hour. We conducted a pilot study in which blood glucose levels, meal and insulin logs, and activity-related parameters, like heart rate and steps, were collected from 5 individuals over a period of 2 weeks. This data was used to develop algorithms for glucose level prediction based on a number of models, including: long short-term memory (LSTM) recurrent neural network (RNN), Gaussian Process (GP), Lag Method and Clockwork RNN. The predictions using the LSTM model yielded the best performance. With the inclusion of additional features, the RMSE for a 1 hour prediction horizon using the LSTM RNN was 8.71 ± 3.98 mg/dL. However, work must still be done to improve performance and determine the importance of each feature.

Disclosure
D. Colburn: None. V. Behnam Roudsari: None. R. Gandica: None. S. Sia: None.
1001-P: Effects of Efpeglenatide on Body Weight, BMI, and Waist Circumference in Patients With Obesity Without Diabetes Stratified by Baseline Characteristics: A Subanalysis of BALANCE 205
Authors: PRATLEY RICHARD E. , JACOB STEPHAN , KANG JAHOON , TRAUTMANN MICHAEL E. , HOMPESCH MARCUS , HAN OAKPIL , STEWART JOHN A. , OGBAA IKE , SORLI CHRISTOPHER H. , YOON KUN-HO 
Published: June 2019

Once-weekly (QW) subcutaneous efpeglenatide (efpeg) is a long-acting GLP-1 RA being developed to improve glycemic control in patients with T2D. In the BALANCE 205 study (NCT02075281) in patients with obesity (median BMI 34.9 [28.1−57.7] kg/m2) without diabetes, all doses of efpeg (4 or 6 mg QW; 6 or 8 mg once every 2 weeks [Q2W]) significantly reduced body weight (BW) from baseline (BL) to Week 21 vs. placebo (PBO, p&lt;0.0001; primary endpoint). In this exploratory subgroup analysis, the effects of efpeg (in each treatment arm or pooled data) on BW, BMI, and waist circumference (WC) from BL to Week 21 vs. PBO were investigated in patients stratified by BMI, WC, and age (&lt; or ≥ median BL values). All efpeg groups were associated with significant reductions in BW and BMI from BL vs. PBO across all subgroups (Table). Efpeg also led to significant reductions in WC vs. PBO across subgroups apart from lower doses of efpeg in subgroups with BMI and WC ≥ median (4 mg QW and 6 mg Q2W), and age ≥ median (4 mg QW). The observed adverse events mirrored those known for GLP-1 RAs.
In conclusion, all doses of efpeg led to consistent, significant reductions in BW and BMI in patients with obesity without diabetes in all subpopulations tested; results were consistent with those of the overall BALANCE population.

Disclosure
R.E. Pratley: Consultant; Self; Sanofi US. Other Relationship; Self; AstraZeneca, Eli Lilly and Company, GlaxoSmithKline plc., Janssen Global Services, LLC., Janssen Research & Development, Lexicon Pharmaceuticals, Inc., Ligand Pharmaceuticals, Inc., Merck Sharp & Dohme Corp., Mundipharma, Novo Nordisk Inc., Pfizer Inc., Sanofi, Takeda Development Center Americas, Inc. S. Jacob: Advisory Panel; Self; AstraZeneca, Bayer AG, Boehringer Ingelheim International GmbH, Novo Nordisk A/S. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Lilly Diabetes, Novartis AG, Novo Nordisk A/S, Roche Diabetes Care, Sanofi. J. Kang: Employee; Self; Hanmi Pharm. Co., Ltd. M.E. Trautmann: Consultant; Self; CeQur Corporation, Hanmi Pharm. Co., Ltd., Intarcia Therapeutics, Inc., Oramed Pharmaceuticals, ProSciento, Servier. Stock/Shareholder; Self; Lilly Diabetes. M. Hompesch: Stock/Shareholder; Self; ProSciento. O. Han: None. J.A. Stewart: Employee; Self; Sanofi. Stock/Shareholder; Self; Sanofi. I. Ogbaa: Stock/Shareholder; Self; Lexicon Pharmaceuticals, Inc. Other Relationship; Self; Sanofi. C.H. Sorli: Employee; Self; Sanofi. K. Yoon: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp & Dohme Corp., Novo Nordisk Inc. Speaker's Bureau; Self; Takeda Pharmaceutical Company Limited.

Funding
Hanmi Pharmaceutical, Co., Ltd.; Sanofi