bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Kurikulum Tahfizh Al Qur'an Di Pondok Pesantren Al Qur'an
Authors: Yasri Hayyun Lathifaty 
Published: September 2019

<p><em>This reseach was aims to 1) develop a curricula document which have fulfill the expediency criteria for An Nur Qur’anic Islamic Boarding School of Malang, 2) know the expediency of the product that developed for An Nur Qur’anic Islamic Boarding School of Malang. The curriculum development in this reseach was used Beachamp Development Model which deliver: 1) the curricula document which have fulfill the expediency criteria to be applied in the An Nur Qur’anic Islamic Boarding School of Malang. 2) The application of the developed curriculum was been responsed good by the user. The distinction of this developed curricula with another curricula is the content of the developed curricula were cover the students need which include islamic sciences, qur’anic sciences, and sciences. In othes side, this curricula was developed the simmulation in its evaluation system. This simmulation was developed for testing students automatical memorize of Al Qur’an. So, the suggestion for this research is 1) adding the facility for supporting the student learning and memorizing. 2) The organizator should strengthen the student discipline system, especially in order to memorize the Holy Qur’an. 3) The Procurement of montly evaluation which was scheduled to evaluate student memorize progress.</em></p>
Technology Focus: Tight Reservoirs
Authors: Kalfayan Leonard 
Published: September 2019

Technology Focus
The industry has an increasingly difficult battle on its hands when it comes to unconventional-resource development in the lower-for-longer oil price environment in which we continue to dwell. Taking measures to reduce well costs and reduce rig use while trying to meet or exceed field production targets and increase resource recovery is a daily challenge—in other words, trying to get more with, and out of, less.
Since this time last year, operator and service provider efforts to optimize well and fracture cluster spacing in new completions has increased. Room and desire, of course, remain for collaborative improvement. Restimulation of existing wells also has been on the rise, but implementation is still quite limited relative to new-well drilling and completion. The optimal restimulation procedure in a particular unconventional play is still largely in question; results from one approach or another in one formation can vary greatly from those same approaches in another formation. Also, additional attention continues to be placed on improved-oil-recovery and enhanced-oil-recovery (IOR/EOR) methods applicable in tight reservoirs and shales, but approaches are still in the experimental stage, realistically and•understandably.
To continue to advance optimization in new-well completions, to cost-effectively restimulate existing wells, and to enhance recovery will require capacity for laboratory studies and field trial programs and implementation of a range of analytical methodologies to accelerate application of lessons•learned.
Along those lines, three papers are featured this month. The first provides a detailed review of IOR/EOR methods applied in unconventional oil reservoirs, including numerical modeling studies, laboratory investigations, and field trial studies. The second addresses well spacing and completion optimization by use of a fast-paced optimization work flow. The third discusses methods to optimize fracturing and fluid design using public data across multiple basins and various analytical and statistical methods to identify trends and the key parameters that can lead more rapidly to stimulation optimization.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 192808 Increasing Stimulated Reservoir Volume in Unconventional Reservoirs: A Microstructural and Rock Mechanical Study by Ayyaz Mustafa, King Fahd University of Petroleum and Minerals, et al.
Efficacy of Goal-Directed Fluid Therapy Monitored by Pulse-Pressure Variation Using a C ontinuous Non-Invasive Arterial Pressure Monitoring System (the CNAPTM System) During Parathyroidectomy in Patients with End-Stage Renal Failure - A randomized trial
Authors: Song Jie , Liu Xiaofen , Jiang Weiwei , Wang Jiayou , Li Yun , Chen Hong , Zhang Ye 
Published: September 2019

Abstract
Background: There are no well-recognized guidelines for intraoperative fluid management in patients with end-stage renal failure (ESRF) . Goal-directed fluid therapy (GDFT) is a concept of perioperative fluid management that improves patients’ prognosis. Dynamic indicators better predict fluid response than static indicators.
Aim: In this study, we assessed a GDFT protocol with monitoring of pulse pressure variation (PPV) in patients with ESRF undergoing parathyroidectomy.
Methods: The study included 102 patients who underwent elective parathyroidectomy. They were randomized to a control group (restrictive group, n = 51) that was managed with a restricted fluid regimen or a PPV group (GDFT group, n = 51) that was given a normal saline infusion and was monitored for change in PPV during the intraoperative period. If PPV reached >13%, 250 mL normal saline was administered over 15 min. Ephedrine was given at increments of 6 mg to keep mean arterial pressure >65 mmHg . Hemodynamic variables in the perioperative period were recorded. The primary endpoint was the occurrence of postoperative hypotension.
Results: The occurrence of postoperative hypotension in the GDFT group was lower than in the restrictive group (0 vs. 11.67%, P = 0.027). The patients with complications in the GDFT group was lower than in the restrictive group (35.3% vs. 54.9%, P = 0.047). The volume of saline infused during the intraoperative period was 364 (219-408) mL in the GDFT group and 50 (50-50) mL in the restrictive group ( P = 0.001). Ephedrine was given to 16/51 (29.4%) of the GDFT group and 27/51 (52.9%) of the restrictive group ( P = 0.027).
Conclusion: The use of goal-directed fluid therapy with the dynamic PPV indicator in patients with ESRF undergoing parathyroidectomy guides the administration of infused fluids, with reduced incidence of postoperative hypotension.
Effect Of Long Term Inhaled Corticosteroid Therapy On Adrenal Suppression, Growth And Bone Health In Children With Asthma
Authors: Anuradha K W D A , Prematilake G L D C , Batuwita B A U I , Kannangoda KASR , Hewagamage U S , Wijeratne S , Lankatilake Kantha , de Silva KSH 
Published: September 2019

Abstract
Abstract
Background
Inhaled corticosteroids(ICS) are the most effective treatment for children with persistent asthma .However adverse effects of ICS on Hypothalamo Pituitary Adrenal (HPA) axis, growth and bone metabolism are a concern. Hence the primary objective of this study was to describe the effects of long term inhaled corticosteroid therapy (ICS) on adrenal function, growth and bone health in children with asthma in comparison to an age and sex matched group of children with asthma who were not on long term ICS. .Describing the association between the dose of ICS and duration of therapy on the above parameters were secondary objectives.
Method
Seventy children with asthma on ICS and 70 controls were studied. Diagnosis of asthma in selected patients was reviewed according to the criteria laid down by GINA 2018 guidelines .The estimated adult heights were interpreted relative to their Mid Parental Height (MPH) range. Serum calcium, alkaline phosphatase and vitamin D levels were analyzed in both groups and cortisol value at 30 minutes following a low dose short synacthen test was obtained from the study group. The average daily dose of ICS (Beclamethasone) was categorized as low, medium and high (100-200, 200-400, >400 ug /day) respectively according to published literature.
Results
Heights of all children were within the MPH range. There was no statistically significant difference in the bone profiles and vitamin D levels between the two groups (Ca: p=0.554, vitamin D: p=0.187) but vitamin D levels were insufficient (<50 nmol/l) in 34% of cases and 41% of controls. Suppressed cortisol levels were seen in 24%. Doses of ICS were low, medium and high in 56%, 32% and 12% of children respectively. The association between adrenal suppression with longer duration of therapy (p<0.01) and with increasing dose of ICS (p<0.001) were statistically significant.
Conclusion
ICS had no impact on the growth and bone profiles but its dose and duration were significantly associated with adrenal suppression.
Key Words- Asthma, Inhaled corticosteroids, Growth, Adrenal suppression, Bone Metabolism, Vitamin D
Optimal treatment for Elderly Patients with Resectable Proximal Gastric Carcinoma: A Real World Study Based on National Cancer Database
Authors: Wang Xuefei , Zhao Junjie , Fairweather Mark , Yang Tingsong , Sun Yihong , Wang Jiping 
Published: September 2019

Abstract
Background: High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks and survival benefits of different strategies treated in this group.
Methods: Octogenarians (≥80 years) with resectable proximal gastric carcinoma who were recommended for surgery were identified from National Cancer Database during 2004-2013.
Results: Patients age ≥80 years with PGC were less likely to be recommended or eventually undergo surgery compared to younger patients. Patients with surgery had a significantly better survival than those without surgery (5-year OS: 26% vs. 7%, p<0.001), especially in early stage patients. However, additional chemotherapy (HR: 0.94, 95% CI: 0.82-1.08, P =0.36) or radiotherapy (HR: 0.97, 95% CI: 0.84-1.13, P =0.72) had limited benefits. On multivariate analysis, surgery (HR: 0.66, 95% CI: 0.51-0.86, P =0.002) was a significant independent prognostic factor, while extens ive surgery had no survival benefit (Combined organ resection: HR: 1.88, 95% CI: 1.22-2.91, P =0.004; number of lymph nodes examined: HR: 0.99, 95% CI: 0.97-1.00, P =0.10). Surgery performed at academic and research (AR) medical center had the best survival outcome (5-year OS: 30% in AR vs. 18%-27% in other programs, P <0.001) and lowest risk (30-day mortality: 1.5% in AR vs. 3.6%-6.6% in other programs, P <0.001; 90-day mortality: 6.2% in AR vs. 13.6%-16.4% in other programs, P <0.001) compared to other facilities.
Conclusions: Less-invasive approach performed at academic and research medical center might be the optimal treatment for elderly patients aged ≥80 yrs with early stage resectable PGC.
Comparison of three surgical approaches for thoracolumbar junction (T12-L1) tuberculosis: a multicentre, retrospective study
Authors: Zeng Yanping , Cheng Peng , Tan Jiulin , Li Zhilin , Chen Yuan , Li Li Tao , Zheng Yonghong , Wang Gaoju , Xu Jianzhong , Zhang Zehua 
Published: September 2019

Abstract
Background: The surgical approaches to thoracolumbar junction (T12-L1) tuberculosis were controversial. We aimed to compare the safety and efficacy of three surgical approaches through a multicentre retrospective study.
Methods: The medical records of thoracolumbar junction tuberculosis patients (n = 177) from January 2005 to January 2015 were collected and reviewed. 45 patients underwent anterior debridement and instrumented fusion (Group A), 52 underwent anterior combined with posterior debridement and instrumented fusion in a single- or two-stage procedure (Group B) and 80 underwent posterior debridement and instrumented fusion (Group C). Patients with neurological deficit were 10 in Group A, 23 in Group B, 36 in Group C. All patients had a standard preoperative and postoperative anti - tuberculous therapy regimen. Clinical outcomes, laboratory indexes and radiological results of the three groups were compared. Operations at each centre were performed by the same senior medical team in each centre.
Results: All three surgical approaches achieved bone fusion and pain relief. All patients with neurological deficits had different degrees of recovery after surgery. The operative time was 330.2±45.4min, 408.0±54.3min, 227.9±58.5min, and the blood loss was 744.0±193.8ml, 1134.6±328.2ml, 349.8±289.4ml in groups A, B and C respectively.
The mean loss of correction was 5.5±3.7° in group A, 1.6±1.9° in group B, 1.7±2.2° in group C, and the difference between groups except B vs C were of statistically significant (P < 0.05).
Conclusions: For patients with thoracolumbar junction (T12-L1) tuberculosis, the posterior-only procedure is superior to the anterior-only procedure in the correction of kyphosis and maintenance of spinal stability. The posterior-only procedure is recommended because it achieves the same efficacy as the anterior-only or combined procedure but with shorter operation times, less trauma and less blood loss.

Keywords: Spinal tuberculosis; Thoracolumbar junction lesion; Surgical treatment; Outcome.
Population’s unmet needs in relation to primary care in Romania- a pilot survey in County Brasov.
Authors: Neculau Andrea Elena , Rogozea Liliana , Popa Daniela , Atudorei Ioana , Leasu Florin , Moga Marius Alexandru , Lacatus Anca 
Published: September 2019

Abstract
Background
Patients’ expectations and needs for healthcare services are changing. These changes are correlated with changes in disease profiles, a higher prevalence of chronic diseases, the introduction of new and innovative treatments and health technologies, and the emergence of new social and economic contexts.
National health reports on Romania show that decisions in healthcare planning are not correlated with the health needs of the population. At the same time, this report shows a high degree of unmet healthcare needs of the Romanian population (related to cost, distance and waiting times), especially for low-income populations.
The objective of the study was to identify the unmet needs of the population in relation to primary care medical services in the context of actual health regulations through a pilot study in a representative county in Romania.
Methods
The study is survey-based, and part of a health needs assessment programme commissioned by the District Health Authority to the university. A questionnaire with 21 items was designed to gather information about the structures, processes and outcomes of primary care from the perspective of the population. A total of 877 questionnaires were returned and validated. The data were analysed with SPSS version 25.
Results
Access to primary care was considered to be good by most of the population. Most of the settlements have a family doctor, and 80.5% can schedule an appointment on the same or the following day. Most basic medical services are provided, except for out-of-hours primary care services and cervical cancer screening. The family doctors are considered to be a reliable health resource.
Conclusions
Despite limitations in the practice of family medicine in Romania and therefore a narrow spectrum of services offered by primary care in general, the level of contentment of the population with this healthcare resource is still high. Barriers to access are related to the lack of some essential services, especially preventive and out-of-hours services. Unmet needs are presumably not recognised by patients due to a lack of medical culture. Further research is needed to clarify this conclusion.
Key words: unmet health needs, primary care, Romania
Risk factors for recurrent vitreous haemorrhage in patients with proliferative diabetic retinopathy.
Authors: BAGET-BERNALDIZ Marc , Romero-Aroca Pere , Mercado-Gonzalez Joaquin , Bautista-Perez Angel , Soler-Lluís Núria , Navarro-Gil Raúl 
Published: September 2019

Abstract
Background : To investigate which demographic and clinical factors are related to the presence of recurrent vitreous haemorrhage in a population of diabetic patients diagnosed with proliferative diabetic retinopathy [PDR]. Methods: This was a retrospective review-based study. We studied 285 eyes from 165 patients with PDR. We recorded age, gender, type of diabetes mellitus [DM] , type of DM treatment, history of hypertension and body mass index, panretinal photocoagulation status and the presence of concomitant anticoagulant or antiplatelet treatment. We evaluated the mean glycosylated haemoglobin, mean haemoglobin, the urine albumin to creatinine ratio and the estimated glomerular filtration rate in each patient. In addition, we recorded the smoking history [pack-years] and the systemic complications related to DM. We used the logistic regression analysis to study which independent variables were significantly related to the presence of recurrent vitreous haemorrhage. Results: In total, 183 eyes [64%] with PDR had vitreous haemorrhage, of which 68 [37%] underwent recurrent vitreous haemorrhage. In our study, tobacco consumption [OR= 1.21, 95% CI, 1.10- 1.32, P <0.001], duration of diabetes [OR= 1.03, 95% CI, 1.0-1 .07 P = 0.04] and haemoglobin level [OR= -0.24 , 95% CI, -0.16, -0.06 , P <0 .001] had an independently significant associaton with recurrent vitreous haemorrhage. There was a positive correlation between pack-years consumed and the number of vitreous haemorrhages [r=0.339; p<0.001]. In addition, patients with diabetic polineuropathy, myocardial infarction and ischemia in lower limbs had more vitreous haemorrhage events [p<0.001]. Conclusion s : In our study, those patients with PDR who smoked, with longer duration of their diabetes, anaemia and that had previously suffered from cardiovascular events were more prone to suffer from recurrent vitreous haemorrhage.
Tongue pressure resistance training for swallowing impairment post-stroke: study protocol for a randomized crossover clinical trial
Authors: Smaoui Sana , Richardson Denyse , Peladeau-Pigeon Melanie , Steele Catriona 
Published: September 2019

Abstract
Introduction For patients who have suffered a stroke, tongue strength may be decreased compared to healthy individuals. Patients with dysphagia following stroke are more likely to experience aspiration pneumonia, which has been associated with higher mortality rates and medical complications. Research on strengthening the tongue in the stroke population has shown positive effects of a tongue resistance training protocol. Research also suggests that swallow safety, or protection of the airway, may be improved as a result of such interventions, however the mechanism of improvement remains poorly understood, particularly whether improvement is attributed to the intervention alone, or to spontaneous recovery. This study aims to determine what aspects of the swallowing mechanism (response time, movement, etc. of different structures) are directly impacted in order to provide guidance to clinicians using such treatments.Methods and analysis A multi-site, assessor-blinded, randomized crossover trial was designed to determine the effects of a 4-week course of tongue pressure intervention supplemented with home practice in participants who experience dysphagia (PAS of 3 or greater) at baseline. An instrumental evaluation of swallowing (videofluoroscopic swallowing study) is utilized at baseline to determine whether swallowing safety is impaired. Additionally, a requirement for reduced tongue pressures (<40 kilopascals) on all three trials was added in order to target patients who would benefit from this training. Participants are randomized into a delayed treatment group or an immediate treatment group to control for the effects of spontaneous recovery. All participants receive the 4 week treatment consisting of 2 weekly sessions with a speech-language pathologist and complete daily homework plans. Videofluoroscopic swallowing studies are also performed pre and post intervention to quantify the degree of change attributed to the intervention. The study launched in May 2019 and will enroll a maximum of 40 participants.Discussion This study will explore the effects of tongue pressure intervention on swallowing parameters in patients presenting with dysphagia post-stroke. Describing how the intervention effects specific swallowing mechanisms will provide guidance to clinicians using such treatments with this population. Trial registration number ClinicalTrials.gov identifier NCT03969095, published May 31 2019; https://clinicaltrials.gov/ct2/show/NCT03969095?term=NCT03969095&rank=1
Association studies of candidate single-nucleotide polymorphisms with Symptomatic Intracranial Atherosclerotic Stenosis in a Chinese Han population
Authors: Yu Fang , Zhou Xiaoqing , Zeng Sian , Feng Xianjing , Li Zhibin , Wang Junyan , Zhan Qiong , Yan Junxia , Xiao Bo , Xia Jian 
Published: September 2019

Abstract
Background: Genetic factors underlying predisposition to Symptomatic Intracranial Atherosclerotic Stenosis (sICAS) remain unknown, the purpose of the present study was to identify genetic variants that confer susceptibility to sICAS in a Chinese Han population. Methods: The study population comprised of 379 Chinese individuals, including 193 patients with sICAS and 186 unrelated healthy controls. A total of 96 polymorphisms selected by genome-wide association or candidate-gene association studies of atherosclerosis and atherosclerotic diseases were examined in the present study with the use of Illumina VeraCode technology. Statistical analyses were performed with PLINK and SPSS software, and each genotype was assessed according to dominant, recessive, and additive genetic models. Results: Comparisons between subjects with sICAS and controls revealed that rs3798220 of the lipoprotein(a) gene (LPA) and rs9818870 of the muscle RAS oncogene homolog gene (MRAS) were significantly (P<0.0005, Bonferroni correction) associated with the prevalence of sICAS. Comparisons of genotypes in three genetic models (dominant, recessive and additive models) between groups showed that rs3798220 (LPA) was associated with sICAS in the dominant model (P=0.000005, OR=2.629, 95% CI=1.735-3.985) and additive model (P=0.000005, OR=2.293, 95% CI=1.605-3.276),while rs9818870 (MRAS) was associated with sICAS in the additive model (P=0.000464, OR=3.245, 95% CI=1.679-6.272). Furthermore, logistic regression analysis showed that the genotype distribution of rs3798220 (LPA) was significantly associated with sICAS, with its minor C allele elevating sICAS risk (P=0.00002, dominant model, OR=3.951, 95% CI=2.100-7.434 and P=0.000053, additive model, OR=2.916, 95% CI=1.736-4.899). While rs9818870 (MRAS) showed no such significance (P>0.0005). Conclusion: LPA rs3798220 might be susceptibility loci for sICAS in Chinese Han individuals. Keywords: Symptomatic Intracranial Atherosclerotic Stenosis; risk factors; candidate gene; SNP.