bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the National Clinical Database to evaluate the association between preoperative liver function and postoperative complications among patients undergoing hepatectomy
Authors: Kubota Keiichi , Aoki Taku , Kumamaru Hiraku , Shiraki Takayuki , Miyata Hiroaki , Seto Yasuyuki , Kakeji Yoshihiro , Yamamoto Masakazu 
Published: June 2019

AbstractBackgroundThe aim of the present study was to clarify the association between preoperative liver function and complications after hepatectomy.MethodsThe study included 11,686 patients registered in the National Clinical Database for 2015 for whom data on indocyanine green at 15 min (ICG15) and hepatectomy were available. The patients were divided into four groups: group A (ICG15 <10%; n = 5,661), group B (ICG15 10% to <20%; n = 4,381), group C (ICG15 20% to <30%; n = 1,173) and group D (ICG15 >30%; n = 463). Hepatectomy procedures were classified as partial resection (n = 3,934), systematic subsegmentectomy (n = 2,055), monosectionectomy (n = 2,043), bisectionectomy (n = 2,993) and trisectionectomy (n = 208). Complications were classified using the Clavien‐Dindo classification (CD) and evaluated by ICG15 category and procedure type.ResultsComplications more severe than CD III increased significantly as the operation time lengthened and the intraoperative bleeding volume increased (P < 0.001). ICG15 category was positively associated with operative death, >CD III complications, surgical site infection (SSI), liver failure, and intractable ascites for many of the major hepatectomy procedures, but not with bile leakage. More complications were observed in patients outside the Makuuchi criteria than in those within the criteria.ConclusionsOperation time and intraoperative bleeding volume are significantly associated with severe postoperative complications in patients undergoing hepatectomy. ICG15 is a good indicator predictive of operative death, >CD III complications, SSI, liver failure and intractable ascites.
Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits
Authors: Udobi Kenea C. , Delcimmuto Nicholas , Kokenge Amanda N. , Abdulla Zuhair I. , Perna Marla K. , Skelton Matthew R. 
Published: June 2019

AbstractCreatine (Cr) is a guanidino compound that provides readily available phosphate pools for the regeneration of spent adenosine triphosphate (ATP). The lack of brain Cr causes moderate to severe intellectual disability, language impairment, and epilepsy. The most prevalent cause of Cr deficiency are mutations in the X‐linked SLC6A8 (Creatine transporter; CrT) gene, known as CrT deficiency (CTD). One of the most critical areas that need to be addressed is whether Cr is necessary for brain development. To address this concern, the Slc6a8 gene was knocked out in either neonatal (postnatal day (P)5) or adult (P60) mice using a tamoxifen‐inducible Cre recombinase driven by the human ubiquitin C (UBC) promoter. Mice were tested in the Morris water maze, novel, object recognition, and conditioned fear 60 days after Slc6a8 deletion. In addition, overnight locomotor activity was analyzed. Mice that had the gene deleted on P5 showed deficits in the Morris water maze and novel object recognition, while there were no deficits in P60 knockout mice. Interestingly, the P5 knockout mice showed hyperactivity during the dark phase; however, when examining control mice, the effect was due to the administration of tamoxifen from P5 to 10. Taken together, the results of this study show that Cr is necessary during periods of brain development involved in spatial and object learning. This study also highlights the continued importance of using proper control groups for behavioral testing.
Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells
Authors: Wisgrill Lukas , Wessely Isabelle , Netzl Antonia , Pummer Linda , Sadeghi Kambis , Spittler Andreas , Berger Angelika , Förster-Waldl Elisabeth 
Published: June 2019

Abstract
Plasmacytoid dendritic cells (pDCs) are key players in the antiviral immune response and type III IFNs such as IL-29 appear to play a pivotal role in pDC function. Pronounced susceptibility to viral infections in neonates is partly resulting from diminished antiviral immune mechanisms. Accordingly, the aim of the present study was to investigate the impact of IL-29 in the altered immune response of neonatal pDCs. PBMCs of adult and term newborns were stimulated with CpG-ODN2216 in the presence or absence of IL-29 and assessed for IFN-α production, downstream-signaling, and activation marker expression. A significantly lower IL-29 production after TLR9-specific stimulation was demonstrated in neonatal pDCs. IL-29 enhanced the IFN-α production of pDCs in adults compared to newborns. Newborn pDCs displayed a significantly lower surface expression of IL-10 and IL-28Rα receptor resulting in diminished STAT1 and IRF7 activation. Interestingly, concomitant stimulation with CpG-ODN2216/IL-29 had no impact on the expression of surface activation and maturation markers of pDCs in neither population. The diminished antiviral immune response of neonatal pDCs is associated with reduced production and cellular responses toward IL-29. Potential therapeutic agents enhancing the IL-29 response in neonatal pDCs possibly augment viral protection in newborns.
Primary trichodysplasia spinulosa polyomavirus infection in a kidney transplant child displaying virus‐infected decoy cells in the urine
Authors: Borgogna Cinzia , Albertini Silvia , Zavattaro Elisa , Veronese Federica , Peruzzi Licia , van der Meijden Els , Feltkamp Mariet C.W. , Tosoni Antonella , Volpe Alessandro , Boldorini Renzo , Gariglio Marisa 
Published: June 2019

AbstractWe report a case of primary trichodysplasia spinulosa (TS) infection in a kidney transplant child and describe for the first time the presence of degenerated TS‐associated polyomavirus (TSPyV)‐infected cells in a TS patient's urine that are morphologically different from BK or JC polyomavirus‐infected decoy cells.
Spatiotemporal soil moisture variations associated with hydro‐meteorological factors over the Yarlung Zangbo River basin in Southeast Tibetan Plateau
Authors: Li Xueying , Liu Liu , Li Hao , Wang Shuping , Heng Jingxia 
Published: June 2019

AbstractSoil moisture (SM) is a key factor in the exchanging process of the hydrological cycle, which is rather difficult to be directly observed. In situ measurements on SM, however, are subjected to the point scales. Use of land surface models has been a promising way to explore SM variations, especially for poorly gauged high mountain regions such as the Yarlung Zangbo River (YZR) basin located in Southeast Tibetan Plateau. This study made an attempt to investigate the spatiotemporal variations of SM and discuss hydro‐meteorological factors impacting SM evolution based on the Global Land Data Assimilation Systems (GLDAS) outputs during the period 1970–2009. Results show that (a) GLDAS data sets have high agreement and low bias with in situ measurements and consistent spatial distribution with ERA reanalysis data sets; (b) an abrupt change of SM is detected in 1992 and a significantly decreasing trend happens during 1970–2009 and 1993–2009; (c) precipitation is the dominant climatic factor controlling SM during the period 1970–2009, whereas surface air temperature is the critical factor for the significant change of SM. Owing to the significant increasing of surface air temperature since 1992, its impact on SM increased by ∼91% than that before 1992. Evapotranspiration (ET) and snow water equivalent (SWE) are also taken into consideration, showing relatively weak influence on SM, which may be due to the dynamic process of coupled SM‐ET or low snow cover area fraction across the YZR basin. Findings in this study have important implications for SM variations in poorly gauged high mountain regions which may largely influences downstream water availability.
A Comparative Analysis of Equations to Estimate Patient Energy Requirements Following Cardiopulmonary Bypass for Correction of Congenital Heart Disease
Authors: Roebuck Natalie , Fan Chun‐Po Steve , Floh Alejandro , Harris Zena Leah , Mazwi Mjaye L. 
Published: June 2019

AbstractBackgroundNo consensus exists on the optimal method to estimate resting energy expenditure (REE) in critically ill children following cardiopulmonary bypass (CPB). This study assesses the accuracy of REE estimation equations in children with congenital heart disease following CPB and tests the feasibility of using allometric scaling as an alternative energy prediction equation.MethodsA retrospective analysis of a pediatric cohort following CPB (n = 107; median age 5.2 months, median weight 5.65 kg) who underwent serial measures (median 5 measurements) of REE using indirect calorimetry for 72 hours following CPB. We estimated REE using common estimation methods (Dietary Reference Intake, Harris Benedict, Schofield, World Health Organization [WHO]) as well as novel allometric equations. We compared estimated with measured REE to determine accuracy of each equation using overall discrepancy, calculated as a time‐weighted average of the absolute deviation.ResultsAll equations incorrectly estimated REE at all time points following CPB, with overestimation error predominating. WHO had the lowest discrepancy at 10.7 ± 8.4 kcal/kg/d. The allometric equation was inferior, with an overall discrepancy of 16.9 ± 10.4. There is a strong nonlinear relationship between body surface area and measured REE in this cohort, which is a key source of estimation error using linear equations.ConclusionIn a cohort of pediatric patients with congenital heart disease following CPB, no currently utilized clinical estimation equation reliably estimated REE. Allometric scaling proved inferior in estimating REE in children following CPB. Indirect calorimetry remains the ideal method of determining REE after CPB until nonlinear methods can be derived due to overestimation using linear equations.
Lymphoscintigraphy for the diagnosis of extremity lymphedema: Current controversies regarding protocol, interpretation, and clinical application
Authors: Pappalardo Marco , Cheng Ming‐Huei 
Published: June 2019

AbstractAppropriate diagnosis, staging and a further selection of the best treatment are fundamental for the management of patients with extremity lymphedema. Several clinical and imaging tools have been described for these purposes. Lymphoscintigraphy is still considered the gold standard imaging modality for diagnosing lymphedema. However, protocol variability and poor image resolution can make the interpretation challenging. Here, we reviewed technical aspects of lymphoscintigraphy, interpretation of the lymphoscintigraphy findings, staging, and its clinical application.
The role of adjunct nanofibrillar collagen scaffold implantation in the surgical management of secondary lymphedema: Review of the literature and summary of initial pilot studies
Authors: Rochlin Danielle H. , Inchauste Suzanne , Zelones Justin , Nguyen Dung H. 
Published: June 2019

AbstractSecondary lymphedema is a worldwide affliction that exacts a significant public health burden. This review examines the etiology, presentation, and management of secondary lymphedema. In addition, emerging adjunctive strategies are explored, specifically evidence from animal and pilot human studies regarding implantation of a collagen nanofibrillar scaffold (BioBridge™; Fibralign Corporation, Union City, CA) in promoting lymphangiogenesis, preventing and treating lymphedema, and enhancing outcomes with lymphaticovenous anastomosis and vascularized lymph node transfer.
Tribological performance of DLC coating under aqueous solutions
Authors: Guo Feifei , Dong Guangneng , Qin Liguo , Zhang Dongya , Guo Junde 
Published: June 2019

AbstractIn the study, the hydrogen‐free diamond‐like carbon (DLC) coating was deposited on the surface of the Co‐Cr‐Mo alloy. Pin‐on‐plate tribotests were performed for the DLC‐coated CoCrMo specimen against un‐doped CoCrMo alloy under bovine serum albumin (BSA), NaCl solution, and distilled water. Results showed that the average coefficient of friction (COF) of the mating system was 0.08 under NaCl and 0.07 under distilled water, respectively. However, the dynamic COF under BSA lubrication was prone to increasing with testing time, and the average COF got to 0.12. The wear morphology of the pin was covered by the carbon transfer layer without BSA lubrication, and the formation of the transfer layer was a dynamic evolution process as wear debris adhesion, continuous transferring, and delamination. Oppositely, the transfer layer was inhibited under BSA lubrication due to the adsorption of the protein layer on the contact interface.
A Novel SGCE Nonsense Variant Associated With Marked Intrafamilial Variability in a Turkish Family With Myoclonus‐Dystonia
Authors: Gultekin Murat , Prakash Neha , Ganos Christos , Mirza Meral , Bayramov Ruslan , Bhatia Kailash P. , Mencacci Niccolò E. 
Published: June 2019

ABSTRACTBackgroundMyoclonus‐Dystonia syndrome (M‐D) is an autosomal‐dominant movement disorder related to SGCE gene pathogenic variants. Although there can be observed variability in clinical findings, here we describe intrafamilial variability in a Turkish family with a novel nonsense SGCE pathogenic variant.MethodsA family with variable clinical symptoms resembling M‐D were referred to our clinic. After preliminary diagnosis, patients were tested for mutations in the SGCE gene by Sanger sequencing.ResultsNovel pathogenic heterozygous nonsense mutation in exon 3, c.272T>G; p.Leu91* (NM_003919.2) were observed in affected family members.ConclusionIntrafamilial clinical variability, despite the same pathogenic variant described in this work, suggests that there are regulatory factors, epigenetic or environmental modifiers, which are the subject of a matter for future studies.
Incidence, demographic characteristics, and geographic distribution of sickle cell trait and sickle cell anemia births in Michigan, 1997–2014
Authors: Reeves Sarah L. , Jary Hannah K. , Gondhi Jennifer P. , Kleyn Mary , Spector‐Bagdady Kayte , Dombkowski Kevin J. 
Published: June 2019

AbstractBackgroundThis study describes the incidence, demographic characteristics, and geographic distribution of sickle cell anemia (SCA) and sickle cell trait births in Michigan.MethodsMichigan newborn screening records and birth certificates (1997–2014) were used to identify sickle cell trait and SCA births, as well as demographic characteristics and mother's residential address. Incidence was calculated overall and by county.ResultsDuring the study period, there were 592 SCA births and 33,404 sickle cell trait births in Michigan. The majority of SCA (86.3%) and trait (80.2%) cases were among children who were black. Children with SCA were born in 23% of Michigan counties; children with trait were born in 93%.ConclusionCompared to SCA, sickle cell trait births occur at 50‐fold greater incidence and have a substantially expanded geographic distribution. Further research is necessary to understand the most appropriate and impactful use of resources to increase the proportion of families and adults that are aware of their sickle cell trait status.
Expression and allele frequencies of Thymic stromal lymphopoietin are a key factor of breast cancer risk
Authors: Semlali Abdelhabib , Almutairi Mikhlid , Reddy Parine Narasimha , Al Amri Abdullah , Almeer Rafa , Alanazi Mohammad S. , Rouabhia Mahmoud 
Published: June 2019

AbstractBackgroundThymic stromal Lymphopoeitin (TSLP) is a key cytokine involved in inflammation and cancer progression. TSLP gene polymorphisms have been associated with increased susceptibility to cancer progression in different organs. We performed a control case study to examine the correlation of expression and polymorphisms of three nucleotides in TSLP with breast cancer (BC) risk in Saudi Arabian females.Materials and methodsThe study was conducted on 116 healthy control subjects and 127 female patients with BC for the purpose of genotyping. Ten matching tissues provided data on immunohistochemistry to evaluate TSLP expression. Three SNPs (rs10043985, rs2289276, and rs3806933) were genotyped with TaqMan allelic discrimination assay. The patients' ages and estrogen receptor statuses were used to investigate the potential correlations between the different variations of TSLP genotypes and BC risk.ResultsBC tissues expressed positive immuno‐staining for TSLP at a high rate compared to normal matching breast tissues. Malignant breast tumors exhibited higher TSLP expression than benign breast tumors. We also found that the rs3806933 (T) allele frequency decreased the risk of developing BC in the study population (OR = 0.356, p = 0.00027) significantly (0.356 times). Interestingly, statistical analysis revealed that the genotype mutant (AC) and the allele mutant (C) of rs10043985 within TSLP were significantly correlated with an increased BC risk (odds ratio [OR] = 4.762, confidence interval [CI] = 1.000–22.666, p = 0.03244; OR = 4.762, CI = 1.000–22.666, p = 0.03244; and OR = 4.575, CI = 0.975–21.464, p = 0.03516, respectively). In addition, the AC and AC + CC genotypes of TSLP rs10043985 were confirmed to be associated with an increased risk of BC risk in women aged above 48 years, compared with the AA genotype (AC and AC + CC vs. AA: OR = 9.468, CI = 0.493–181.768, p = 0.04537).ConclusionThe results reveal significant correlation between SNPs in TSLP and BC progression in Saudi Arabian female patients.
Nearness results for real tridiagonal 2‐Toeplitz matrices
Authors: Bebiano Natália , Furtado Susana 
Published: June 2019

SummaryIn this article, we extend the results for Toeplitz matrices obtained by Noschese, Pasquini, and Reichel. We study the distanced, measured in the Frobenius norm, of a real tridiagonal 2‐Toeplitz matrixTto the closureof the set formed by the real irreducible tridiagonal normal matrices. The matrices in, whose distance toTisd, are characterized, and the location of their eigenvalues is shown to be in a region determined by the field of values of the operator associated withT, whenTis in a certain class of matrices that contains the Toeplitz matrices. WhenThas an odd dimension, the eigenvalues of the closest matrices toTinare explicitly described. Finally, a measure of nonnormality ofTis studied for a certain class of matricesT. The theoretical results are illustrated with examples. In addition, known results in the literature for the case in whichTis a Toeplitz matrix are recovered.
Diaphragmatic paralysis in young children: A literature review
Authors: Gerard‐Castaing Nathalie , Perrin Thomas , Ohlmann Camille , Mainguy Catherine , Coutier Laurianne , Buchs Clelia , Reix Philippe 
Published: June 2019

AbstractDiaphragmatic paralysis (DP) is a rare cause of respiratory distress in young children. In the first years of life, the main cause is phrenic nerve injury after cardiothoracic surgery or obstetrical trauma. DP usually presents as respiratory distress. Asymmetrical thorax elevation, difficulty weaning from mechanical ventilation, pulmonary atelectasis, and repeated pulmonary infections are other suggestive signs or complications. DP is usually suspected on chest X‐ray showing abnormal hemidiaphragm elevation. Although fluoroscopy was considered the gold standard for DP confirmation, it has gradually been replaced by ultrasound, which can be done at the bedside. Some electrophysiological tools may be useful for a better characterization of phrenic nerve injury and chance of recovery. The management of DP is mainly based on clinical severity. In mild asymptomatic cases, DP may only require close monitoring. In more severe cases, adequate ventilatory support and/or surgical diaphragmatic plication may be needed. Electrophysiological tools may help clinicians assess the ideal timing for diaphragmatic plication.
A novel method for infant multiple breath washout: First report in clinical practice
Authors: Shawcross Anna , Murray Clare S. , Pike Katy , Horsley Alex 
Published: June 2019

AbstractBackgroundLung clearance index (LCI), measured using multiple breath inert gas washout (MBW) is a potentially useful test in infants with respiratory disease, particularly cystic fibrosis (CF). Clinical use is limited however by the need for specialist staff and equipment. We have previously described a novel method for infant MBW suitable for use outside of specialist laboratories. This study describes its performance in vivo in infants with CF and healthy controls, including a limited comparison with the respiratory mass spectrometer.MethodsChildren aged less than 2 years with CF and controls underwent MBW testing on a single occasion. The practical applicability of the system was determined by the number of successful duplicate tests and within‐subject repeatability.ResultsTwenty‐five children (seven with CF, 18 healthy controls, all sedated with chloral hydrate) attempted MBW. Twenty patients (seven with CF) successfully underwent duplicate testing (80% success rate). Mean within‐subject coefficient of variation for functional residual capacity (FRC) was 7.2% and for LCI 5.9%. Comparison of LCI with the mass spectrometer was limited but gave very similar values for LCI and FRC in those patients who underwent technically adequate tests with both methods.ConclusionsWe have described a new MBW method that is feasible and reproducible in sedated infants. Results fall within the expected range, and well within accuracy limits set by international guidelines. This could provide a more accessible alternative to previously described systems for infant MBW, and overcomes many of the technical challenges inherent in conventional MBW.
Circulating inflammation markers and prostate cancer
Authors: Ugge Henrik , Downer Mary K. , Carlsson Jessica , Bowden Michaela , Davidsson Sabina , Mucci Lorelei A. , Fall Katja , Andersson Sven‐Olof , Andrén Ove 
Published: June 2019

BackgroundChronic inflammation is thought to influence the risk of prostate cancer. The purpose of this population‐based case‐control study was to evaluate the association of 48 circulating inflammation markers with prostate cancer, to identify candidate markers for further investigation.MethodsSerum samples collected from 235 prostate cancer patients and 198 population‐based controls recruited in Örebro County, Sweden, in 1989‐1991, were assessed using a multiplex bead‐based immunoassay to determine concentrations of 48 circulating inflammation markers. Logistic regression was first used to evaluate the association between individual markers (highest vs lowest concentration quartile) and prostate cancer in unadjusted and mutually adjusted models. Second, patients with inflammatory conditions, metastatic or advanced prostate cancer, were excluded to address the possible influence of systemic disease on inflammation markers.ResultsIndividual analyses first identified 21 markers associated with prostate cancer (P < .05), which after mutual adjustment were reduced to seven markers. After the exclusion of men with conditions linked with systemic inflammation, associations between prostate cancer and deviant levels of C‐X3‐C motif chemokine ligand 1, platelet‐derived growth factor subunit B homodimer, interleukin 10, C‐C motif chemokine ligand (CCL) 21, and CCL11 remained statistically significant.ConclusionsIn this explorative study, we identified candidate inflammation markers of possible importance for prostate cancer pathophysiology, for further evaluation in prospective studies.