bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice Patterns for Older Adult Patients With Advanced Cancer: Physician Office Versus Hospital Outpatient Setting
Authors: Lipitz-Snyderman Allison , Atoria Coral L. , Schleicher Stephen M. , Bach Peter B. , Panageas Katherine S. 
Published: December 2018

PURPOSE: A shift in outpatient oncology care from the physician’s office to hospital outpatient settings has generated interest in the effect of practice setting on outcomes. Our objective was to examine whether medical oncologists’ prescribing of drugs and services for older adult patients with advanced cancer is used more in physicians’ offices compared with hospital outpatient departments. METHODS: This was a retrospective comparative study. SEER-Medicare data (2004 to 2011) were used to identify Medicare beneficiaries diagnosed with advanced breast, colon, esophagus, non–small-cell lung, pancreatic, or stomach cancer. Between physicians’ offices and hospital outpatient departments, we compared use of selected likely low-value supportive drugs, low-value therapeutic drugs, chemotherapy-related hospitalizations, and hospice. We used hierarchical modeling to assess differences between settings to account for correlation within physicians. RESULTS: Compared with patients treated in a hospital outpatient department, those treated in a physician’s office setting were more likely to receive erythropoiesis-stimulating agents (odds ratio, 1.72; 95% CI, 1.53 to 1.94) and granulocyte colony–stimulating factors (odds ratio, 1.28; 95% CI, 1.18 to 1.38). For combination chemotherapy and nanoparticle albumin-bound–paclitaxel in patients with breast cancer, there was a trend toward higher use in physicians’ offices, although this was not statistically significant. Chemotherapy-related hospitalizations and hospice did not vary by setting. CONCLUSION: We found somewhat higher use of several drugs for patients with advanced cancer in physicians’ office settings compared with hospital outpatient departments. Findings support research to dissect the mechanisms through which setting might influence physicians’ behavior.
The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
Authors: Kelly John J. , Abitbol Julia M. , Hulme Stephanie , Press Eric R. , Laird Dale W. , Allman Brian L. 
Published: December 2018

ABSTRACT
Mutations in the genes that encode the gap junction proteins connexin 26 (Cx26, encoded by GJB2) and Cx30 (GJB6) are the leading cause of hereditary hearing loss. That said, the Cx30 p.Ala88Val (A88V) mutant causes Clouston syndrome, but not hearing loss. Here, we report that the Cx30-A88V mutant, despite being toxic to inner ear-derived HEI-OC1 cells, conferred remarkable long-term protection against age-related high frequency hearing loss in Cx30A88V/A88V mice. During early development, there were no overt structural differences in the cochlea between genotypes, including a normal complement of hair cells; however, the supporting cell Cx30 gap junction plaques in mutant mice were reduced in size. In adulthood, Cx30A88V/A88V mutant mice had a reduction of cochlear Cx30 mRNA and protein, yet a full complement of hair cells. Conversely, the age-related high frequency hearing loss in Cx30+/+ and Cx30+/A88V mice was due to extensive loss of outer hair cells. Our data suggest that the Cx30-A88V mutant confers long-term hearing protection and prevention of hair cell death, possibly via a feedback mechanism that leads to the reduction of total Cx30 gap junction expression in the cochlea.
Contractility kits promote assembly of the mechanoresponsive cytoskeletal network
Authors: Kothari Priyanka , Srivastava Vasudha , Aggarwal Vasudha , Tchernyshyov Irina , Van Eyk Jennifer E. , Ha Taekjip , Robinson Douglas N. 
Published: December 2018

ABSTRACT
Cellular contractility is governed by a control system of proteins that integrates internal and external cues to drive diverse shape change processes. This contractility controller includes myosin II motors, actin crosslinkers and protein scaffolds, which exhibit robust and cooperative mechanoaccumulation. However, the biochemical interactions and feedback mechanisms that drive the controller remain unknown. Here, we use a proteomics approach to identify direct interactors of two key nodes of the contractility controller in the social amoeba Dictyostelium discoideum: the actin crosslinker cortexillin I and the scaffolding protein IQGAP2. We highlight several unexpected proteins that suggest feedback from metabolic and RNA-binding proteins on the contractility controller. Quantitative in vivo biochemical measurements reveal direct interactions between myosin II and cortexillin I, which form the core mechanosensor. Furthermore, IQGAP1 negatively regulates mechanoresponsiveness by competing with IQGAP2 for binding the myosin II–cortexillin I complex. These myosin II–cortexillin I–IQGAP2 complexes are pre-assembled into higher-order mechanoresponsive contractility kits (MCKs) that are poised to integrate into the cortex upon diffusional encounter coincident with mechanical inputs.
This article has an associated First Person interview with the first author of the paper.
Το τραύμα στη μεταφρασμένη παιδική και εφηβική λογοτεχνία: The Book Thief
Authors: Κόρκα Νικολέττα 
Published: December 2018

Στην παρούσα εργασία πραγματοποιείται συγκριτική μελέτη του βιβλίου The Book Thief και της μετάφρασής του στα ελληνικά και στα γαλλικά. Μέχρι πολύ πρόσφατα τραγικά γεγονότα, όπως είναι το Ολοκαύτωμα προσεγγίζονταν με μεγάλη αμηχανία στην παιδική και εφηβική λογοτεχνία, ενώ οι εκδοτικοί οίκοι αντιμετώπιζαν το δίλημμα της υποχρέωσης της παρουσίασης της ιστορικής αλήθειας από τη μία και της προσπάθειας να μην τραυματίσουν τους ανήλικους αναγνώστες από την άλλη. Στόχος της εργασίας είναι η διερεύνηση τυχόν διαφοροποιήσεων και προσαρμογών του έργου κατά τη μεταφορά του από τα αγγλικά στα ελληνικά και στα γαλλικά μέσα από τη συγκριτική μελέτη, η διερεύνηση μεταφραστικών στρατηγικών που υιοθετούνται κατά τη διαδικασία της μετάφρασης, εστιάζοντας στη μεταφορά του τραύματος από ένα πολιτισμικό σύστημα σε ένα άλλο και συνάγοντας συμπεράσματα για τον τρόπο με τον οποίο το τραύμα προσεγγίζεται στην εκάστοτε εθνική λογοτεχνία για ανηλίκους.
Η ενίσχυση της ικανότητας αφήγησης φανταστικών ιστοριών παιδιών προσχολικής ηλικίας
Authors: Βρετουδάκη Ελένη , Τάφα Ευφημία 
Published: December 2018

Σκοπός της παρούσας εργασίας ήταν να εξετάσει την επίδραση ενός προγράμματος παρέμβασης για την ενίσχυση της κατανόησης του δομικού πλαισίου των ιστοριών σε παιδιά προσχολικής ηλικίας με στόχο την παραγωγή φανταστικών ιστοριών. Το δείγμα της μελέτης αποτέλεσαν 56 παιδιά ηλικίας 5-6 ετών τα οποία φοιτούσαν σε 5 τάξεις νηπιαγωγείων της πόλης των Χανίων στην Κρήτη. Τα παιδιά του δείγματος χωρίστηκαν σε δύο ομάδες, μία πειραματική και μία ομάδα ελέγχου. Το πρόγραμμα εφαρμόστηκε μία φορά την εβδομάδα για 8 εβδομάδες. Στα παιδιά της πειραματικής ομάδας διαβάστηκαν 8 βιβλία με αφηγηματικά κείμενα. Σε κάθε συνεδρία, μετά την ανάγνωση του βιβλίου, εφαρμόστηκε μια πολυεπίπεδη στρατηγική μέσω της οποίας τα παιδιά εκπαιδεύτηκαν στην κατανόηση της δομής της ιστορίας και στην παραγωγή φανταστικών ιστοριών. Στα παιδιά της ομάδας ελέγχου διαβάστηκαν τα ίδια 8 βιβλία χωρίς να εφαρμοστεί κάποιο συγκεκριμένο πρόγραμμα ενίσχυσης του δομικού πλαισίου των ιστοριών. Τα αποτελέσματα έδειξαν ότι η στρατηγική που εφαρμόστηκε στο πρόγραμμα παρέμβασης βελτίωσε σημαντικά την ικανότητα των παιδιών της πειραματικής ομάδας να κατανοήσουν τα δομικά στοιχεία των ιστοριών και να παράγουν πιο οργανωμένες φανταστικές ιστορίες από ότι τα παιδιά της ομάδας ελέγχου. Επιπλέον, τη μεγαλύτερη βελτίωση στην παραγωγή φανταστικών ιστοριών την παρουσίασαν τα παιδιά που είχαν χαμηλό βαθμό επίδοσης στα αφηγηματικά κριτήρια. Τέλος, η βελτίωση των παιδιών διατηρήθηκε και μετά την είσοδό τους στο δημοτικό σχολείο.
Chondrosarcoma in a paediatric population: A study of 247 cases
Authors: Wu A.-M. , Li G , Zheng J.-W. , Chen C.-H. , Chen D , Qiao Z.-G. , Zhao J.-G. , Wang B , Fu W.-L. , Sheng S.-R. , Wu Y.-S. , Tian N.-F. , Lin Z.-K. , Xu H 
Published: December 2018

Purpose The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarcoma differ from those of the adult population, which have been reported previously? Methods Paediatric patients who were diagnosed with chondrosarcoma were searched for using the case listing session protocol of the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 databases (1973 to 2014). The extracted demographic information includes: age, race, gender, year of diagnosis, tumour sites, tumour histological subtype, grade, stage and treatment. Results A total of 247 paediatric chondrosarcoma patients were extracted and included in our present study. We find that the paediatric patients have significantly better survival rates than the adult patients. The year of diagnosis, tumour sites, tumour histological subtype, grade, stage and surgery received are independent prognostic factors for the survival rate of paediatric chondrosarcoma patients, but race, gender and age are not. Conclusion The paediatric chondrosarcoma patients have better survival rates than the adults. Paediatric patients with a diagnosis at an early age, tumour site at the vertebral column and pelvis/sacrococcyx, myxoid variants, high grade, distant stage and who did not have surgery have a poorer prognosis than patients with a diagnosis at a later age, tumour site at limbs, head and base, chondrosarcoma not otherwise specified, lower grade, localized stage and who received surgery. Level of Evidence II -Prognostic Study
Pico de crecimiento y masa muscular en jugadores jóvenes de fútbol.
Authors: Hernández Camacho Juan Diego , Huelva Leal Ana Belen , Martínez-Sanz José Miguel , Lahoz Ruano María Dolores , Vázquez Carrión Javier 
Published: December 2018

Introducción: Se ha observado que el pico de crecimiento podría ser un período importante en el desarrollo de deportistas. Objetivo: Determinar el pico de crecimiento y el estado madurativo en jugadores jóvenes de fútbol y analizar medidas antropométricas relacionadas con el desarrollo corporal.Material y métodos. Cincuenta y ocho jugadores se clasificaron en 3 categorías de edad diferentes, Sub-19 (post-pico de crecimiento), Sub-16 (en el pico) y Sub-14 (pre-pico). Se midieron la altura, la altura sentado, el peso, perímetros y pliegues para determinar el pico de crecimiento, el estado madurativo y los componentes corporales. Métodos estadísticos descriptivos (Desviación Estándar), análisis Anova de una vía y correlaciones de Pearson fueron calculados. El nivel de significación se fijó en p<0,05. Resultados. La altura y el peso medios fueron de 167,63 (10,52) cm y 60,12 (12,43) kg, la grasa corporal media fue 13,49 (3,65)%. La masa muscular transversal del brazo, muslo y pantorrilla fueron 41,70 (10,82) cm2, 154,87 (38,02) cm2 and 85,76 (17,67) cm2. El pico de crecimiento y el estado madurativo medios fueron 13,97 (0,53) y 1,00 (1,92) años. Se encontraron diferencias significativas entre las categorías analizadas para los parámetros antropométricos y el estado madurativo. Se obtuvieron correlaciones entre el estado madurativo y los componentes antropométricos. Conclusiones. Se reportaron incrementos en componentes antropométricos y en las áreas musculares tras el pico de crecimiento. Consecuentemente, el pico de crecimiento y el estado madurativos deberían ser tenidos en cuenta en el manejo de deportistas jóvenes.
Integración de las normas locales y supranacionales de control del ejercicio de la abogacía
Authors: Goldfarb Mauricio 
Published: December 2018

La responsabilidad disciplinaria es una de las consecuencias posibles del obrar irregular de los abogados, y se hace efectiva cuando se afecta el correcto ejercicio profesional. La múltiple regulación de la conducta profesional (Ley de Colegiación, Código de Ética del Colegio, Código para la Abogacía del Mercosur y Código de la UIBA) provoca incertidumbres en los operadores jurídicos. Las normas supranacionales tienen aplicación supletoria, deben ser interpretadas en forma armónica y sistemática por el Tribunal de Disciplina en cada caso concreto y no derogan las normas locales en la materia.
El contrato administrativo a futuro
Authors: Alianak Raquel Cynthia 
Published: December 2018

El trabajo ensaya una serie de principios que pueden ser elaborados como propios y específicos de la buena administración en la contratación pública, que complementan los formulados como inherentes a la “buena administración” en general así como los señalados como propios de la contratación pública global. Estos principios, que constituyen a la vez desafíos para el contrato administrativo en el futuro, provienen de focalizar diversos tópicos o cuestiones que pueden darse en la etapa de selección así como en la de ejecución contractual, los cuales deben ser repensados en su contexto, diseño y modalidades de ocurrencia, a fin de que prevalezca el consenso activo, una mayor previsibilidad y predictibilidad para ambas partes, y criterios objetivos de interpretación; y todo ello tendiente a preservar la vida del contrato, evitar futuros conflictos que pueden eludirse, y satisfacer los intereses públicos y las necesidades involucradas en el objeto de la contratación.
La politica pubblica per la valutazione di qualità come il modo della valutazione dell'educazione come un bene pubblico
Authors: Godoy Dotta Alexandre 
Published: December 2018

Il presente articolo ha come oggetto l’analisi storica e politica relativa alla nascita del concetto d’insegnamento di qualità nell’organizzazione dell’educazione in Brasile. Per raggiungere questo obiettivo, si concentra sullo status di“diritto all’educazione” o “servizio pubblico educazionale” come bene pubblico. Discorre sull’organizzazione del sistema educazionale brasiliano e presenta considerazioni sul problema delle interpretazioni restrittive e formali del sistema educativo, soprattutt o nei termini della proposta neoliberale tipica degli anni novanta. Sviluppa riflessioni sul concetto di qualità e sulla possibilità di metterlo in pratica, attraverso le determinazioni della Costituzione brasiliana, secondo un’interpretazione sostanziale delle politiche pubbliche valutative.
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Authors: Titarenko A. V. , Shishkin S. V. , Shcherbakova L. V. , Verevkin E. G. , Holmes M. , Bobak M. , Malyutina S. K. 
Published: December 2018

Age-related cognitive changes in the Russian population have not been sufficiently studied.Objective: to assess the time course of changes in cognitive functions (CF) in two serial measurements 9 years apart in the urban population of middle, elder, and senile age and their relationship to education level.Patients and methods. A random male and female sample of45-69-year-old Novosibirsk residents (n=9360; HAPIEE project) was surveyed. CF was tested by standard methods. Resurvey was conducted in a random subsample (n=1663) included in this analysis. The mean follow-up period was 8.8 years (SD 1.1).Results and discussion. The test for semantic verbal fluency revealed its dynamic decline in all age groups, which was steeper in women than in men (p<0.001). Persons aged 70 years and older showed negative changes in memory, verbal fluency, and attention (p<0.001). Persons with primary (6%) and vocational (26%) education had steeper rates of decline in delayed recall (p=0.011; 0.038) than those with university education (35%).Conclusion.It is established that a dynamic decrease in CF begins at the age of55—59years; it is steeper among those aged 70 years and older. An age-related decline in memory function is accelerated in persons with lower educational levels.
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Authors: Canas Paula M. , Porciúncula Lisiane O. , Simões Ana Patrícia , Augusto Elisabete , Silva Henrique B. , Machado Nuno J. , Gonçalves Nélio , Alfaro Tiago M. , Gonçalves Francisco Q. , Araújo Inês M. , Real Joana I. , Coelho Joana E. , Andrade Geanne M. , Almeida Ramiro D. , Chen Jiang-Fan , Köfalvi Attila , Agostinho Paula , Cunha Rodrigo A. 
Published: December 2018

AbstractNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate adenosine A2Areceptors (A2AR), which have been associated with the control of neurodegenerative diseases. Using the rat and mouse kainate model of temporal lobe epilepsy, we now tested whether A2AR control convulsions-induced hippocampal neurodegeneration. The pharmacological or genetic blockade of A2AR did not affect kainate-induced convulsions but dampened the subsequent neurotoxicity. This neurotoxicity began with a rapid A2AR upregulation within glutamatergic synapses (within 2 h), through local translation of synaptic A2AR mRNA. This bolstered A2AR-mediated facilitation of glutamate release and of long-term potentiation (LTP) in CA1 synapses (4 h), triggered a subsequent synaptotoxicity, heralded by decreased synaptic plasticity and loss of synaptic markers coupled to calpain activation (12 h), that predated overt neuronal loss (24 h). All modifications were prevented by the deletion of A2AR selectively in forebrain neurons. This shows that synaptic A2AR critically control synaptic excitotoxicity, which underlies the development of convulsions-induced neurodegeneration.
Penggunaan Tools Assesment Biopsikososial dan Spiritual Anak yang menjadi Korban Perceraian Orang Tua
Authors: - Mayangsari 
Published: December 2018

Abstract. Divorce often produces both positive and negative influences in all aspects of children’s life. This research intends to seek whether parents’ divorce can affect a child’s health condition, psychology and spiritual which are referred as a bio-psychosocial and spiritual tools. By utilizing these tools, it is expected that a better understanding can be drawn to what extent divorce may affect children of divorced parents. This thesis uses a qualitative approach with a case study research methodology where data collection techniques includes interviews, observation and documentation. The findings indicate that biopsychosocial and spiritual tools can provides information on the impact upon children with divorced parents. These impacts can be comprehended through the biological aspects, how health conditions of children altered prior to and following the separation of parents. The psychological and spiritual conditions can be perceived through how a child interacts with the environment. Abstrak. Perceraian kerap kali membawa pengaruh dalam segala aspek kehidupan anak baik pengaruh yang bersifat positif maupun negatif. Penelitian ini perlu dilakukan untuk mengetahui apakah perceraian orang tua dapat mempengaruhi kondisi kesehatan anak, psikologis anak serta spiritual anak atau dapat disebut sebagai biopsikososial dan spiritual. Dengan memperhatikan aspek tersebut diharapkan perceraian tidak menjadi momok yang menakutkan bagi anak karena meskipun orang tua mereka berpisah, mereka masih dapat merasakan kasih sayang seutuhnya dari kedua orang tua. Pendekatan yang peneliti gunakan dalam skripsi ini adalah metodologi penelitian kualitatif dengan penelitian studi kasus, dimana teknik pengumpulan data penulis dilakukan melalui wawancara, observasi dan dokumentasi. Adapun hasil temuan yang peneliti dapatkan mengenai dampak biopsikososial dan spiritual korban perceraian orang tuanya, adalah dapat dilihat melalui aspek biologis yaitu bagaimana kondisi kesehatan anak sebelum dan sesudah perceraian orang tuanya, aspek psikologis yaitu bagaimana konsep diri seorang anak dengan perceraian orang tuanya, aspek sosial dan spiritual adalah bagaimana interaksi seorang anak dengan lingkungan, apakah perceraian benar-benar memberikan pengaruh terhadap aspek-aspek tersebut diatas.
Morphological diversity of Bacillus subtilis
Authors: Irkitova A. N. , Grebenshchikova A. V. , Yatsenko E. S. , Speranskaya N. Y. , Matsyura A. V. 
Published: December 2018

<p><em>Bacillus subtilis</em> is the most studied bacterium from genus <em>Bacillus</em> and this microorganism is widespread in nature. <em>B. subtilis</em> is often found in fresh and seawater, in the rhizosphere, in the soil (especially contaminated with feces and manure). The large variety of strains are available in collections of microorganisms, but strains isolated from the rhizosphere of various plants are particularly interesting for science and practical use. At the same time, the morphological criterion (the form and other features of the colonies) is the main one in the identification of <em>B. subtilis</em> at the first stages of the study and allows to refuse of extraneous strains before use more expensive methods and materials. The article presents the description of the morphological diversity of <em>B. subtilis</em> strains that are used in agriculture. Typical R–colonies are characteristic of bacteria <em>B. subtilis</em>, and we established 2 morphologically diverse forms of these colonies in the studied strains.</p><p> </p>
Seeing the forest through different trees: A social psychological perspective of work addiction
Authors: Tóth-Király István , Bőthe Beáta , Orosz Gábor 
Published: December 2018

We live in exciting times for the scientific study of work addiction, given its increased relevance and the diverse perspectives one might take to approach this phenomenon. Simultaneously, this field does not appear to be unified as a result of several misleading myths, which are addressed by the debate paper of Griffiths et al. (2018). In response, we would like to complement this study by proposing that the construct of interest should be more precisely identified in the context of related constructs and that an integrative framework should be applied, which is able to take into account not just the micro-level characteristics (i.e., individual differences), but meso- (i.e., environmental factors) and macro-level (i.e., societal factors) ones as well.