bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disposable pipette extraction phase based on styrene–divinylbenzene/pernigraniline composite, applied for dexamethasone determination in synovial fluid by HPLC with UV detector
Authors: Soares Francielle Q. , Alvarenga Bruna F. , Ruggiero Marçal A. , Casanova Monise C. , Lima Eliana M. , Rabelo Denilson , Chaves Andréa R. 
Published: October 2018

A reliable method using disposable pipette extraction (DPX) based on composite of pernigraniline and styrene–divinylbenzene (Sty–DVB) copolymer was applied to the analysis of dexamethasone in synovial fluid using high-performance liquid chromatography and ultraviolet (UV) detector (HPLC–UV).
DPX variables, namely, number of draw/eject cycles for extraction or desorption, sample pH, volume, and desorption solvent, were optimized to establish the best sorption equilibrium and analysis time. The highest extraction efficiency value was obtained with 50 μL of synovial fluid mixed with 1950 μL of water, in five cycles of 300 μL of sampling, followed by liquid desorption of the drug with 300 μL of methanol in three cycles. The developed method demonstrated a linear response over the range from 10 to 100 ng/mL, with R2 = 0.993. The limit of quantification (LOQ) was 10 ng/mL. Based on the validation results, the proposed method can be a useful tool to detect dexamethasone levels in synovial fluid.
Fever of unknown origin: evaluation of 30 pediatric patients
Authors: GÜNDEŞLİOĞLU Özlem Özgür , KOCABAŞ Emine , ALHAN Emre , AKSARAY Necmi , ALABAZ Derya , KARAGÜN Barbaros Şahin 
Published: October 2018

Purpose: The aim of this retrospective study is to evaluate the etiology clinical and laboratory features of fever of unknown origin (FUO) diagnosed in 30 pediatric patients. Materials and methods: The clinical data including the etiology, diagnostic approaches and clinical characteristics were retrospectively analysed in 30 pediatric patients with FUO who presented to our clinic in one year period. Results: The median age of the patients was 63 (6-192) months. Among the patients, 12 were male (40%), while 18 were female (60%). The median duration of the fever was 22.5 (3-60) days during hospital admission. The most common physical findings were hepatomegaly and splenomegaly, which were observed in 53. 3 and 40 patients, respectively. The cause of the FUO was detected to be infection in 14 patients (46.6%), connective tissue-vascular diseases in 8 patients (26.7%), malignancies in 5 patients (16.7%), and miscellaneous diseases in 1 patient (3.3%). In two patients (6.6%) the etiology could not be identified. Leishmaniasis, tuberculosis and brucellosis were the most commonly identified infections, whereas juvenile rheumatoid arthritis and acute lymphoblastic leukemia were the most common non-infectious causes. Conclusion: The most common cause of FUO in our study was infection diseases. Connective-vascular tissue diseases and malignancies are also important causes of FUO. In our opinion, detailed patient history, carefully physical examination and close clinical follow-up may reduce the number of the invasive procedures and non-invasive tests.
The relation between performance and oral health in male athletes
Authors: YAPICI Hakan , EROĞLU Oğuz , AYAN Sinan , BAĞLAR Serdar , MEMİŞ Uğur Altay , DOĞAN Ali Ahmet 
Published: October 2018

Objectives:
Oral health is as important to an athlete’s sporting
successas regular exercise and adequate nutrition. The aim of
this study was to investigate the relation between oral health and sporting
performance. Methods: This
prospective study was carried out with male athletes. Athletes' demographic
characteristics, dental care habits, number of decayed, missing or filled
teeth, and sporting performance data were recorded. The Decayed Missing Filled
Teeth (DMFT) index, Significant Caries index (SCI) and Plaque index (PI) were
used to assess oral health. The T-Drill, Zig-Zag, Lateral Change of Direction
(LCD) and 505 tests to assess agility, and 10-, 20- and 30-m short sprint tests
were used to assess speed. The results were
analyzed on SPSS software, and p
values &lt; 0.05 were regarded as significant. Results: Ninety-six
athletes were included in the study. Active
caries was determined in 70.8%. The mean DMFT index value was 3.9 ± 3.7,
mean SCI 10.2, and mean PI 0.9 ± 0.4. DMFT was ≥ 4 in 45.8% of athletes and &lt; 4 in 57.2%.
No difference was determined between subjects with DMFT &lt; 4 and DMFT ≥ 4 in
terms of age, height, body weight, or years engaged in sports. Agility and
speed tests results were superior in subjects with DMFT&lt;4 than in those with
DMFT ≥ 4, and times to completion of performance tests were shorter (p &lt; 0.05). Pearson correlation analysis revealed that DMFT was
positively correlated with agility tests [T-Drill test (r = 0.428), Zig-Zag
test (r = 0.428), LCD test (r = 0.286) and 505 test (r = 0.529)], and speed
tests [short sprint, 10-m (r = 0.309), 20-m (r = 0.336), 30-m (r = 0.449)] (p &lt; 0.05).

Conclusion: Impairment of oral health has an
adverse effect on sporting performance, and this can lead to poorer results in
performance tests such as agility and speed.
Investigation of the influence of the number of modules of a multicluster technological complex and the operations performed by them on the overall performance of the installation using simulation simulations
Authors: Kulikov I. N. , Kolesnik L. L. 
Published: October 2018

Variety of compositions of multicluster tools determines the development of methods aimed at analysis and search of feasible compositions, which meet the requirements and optimal performance (throughput) criteria. Very often in the industry, there is a task to find optimum utilization of the cluster tool. To find a solution various approaches are used, such as input in the system several flows of the semifinished products, increasing overall number of the arms of the robot, etc. In this article cluster tool and throughput dependence on quantity of performed operations of the least loaded module are investigated. It is shown, that with the help of this approach one can easily simplify both finding the solution of the task to composite cluster tool with flows of two different types of wafers and determining schedule of the wafers for maximum and minimum throughput. Relevance of the article is stipulated by substantive and complex choices of both finding optimal composition of the cluster tool and scheduling semifinished products flows (in accordance with variations of the operations in modules) at both the design and exploitation stage.
Berries and large fruits of the Samara region harvest 2016 year of the collection of the research institute «Zhigulevsky garden» as a perspective raw material in the food industry
Authors: Aleksashina S. A. , Makarova N. V. , Demenina L. G. , Antipenko M. I. 
Published: October 2018

One of the most important components of the human diet is the berries and stone fruits. They are rich in sugars, organic acids and biologically active substances - antioxidants. Together, the presented indicators (chemical composition and antioxidant activity) are important for the stable operation of the human body and the technological process when processing plant materials. When analyzing the chemical composition of berries and large fruits from the collection of the Research Institute "Zhigulevskie Gardens", it was revealed that the grade of raw materials influences the determined indexes.The highest value of soluble solids is occupied by the samples of apricot (leading Krugly variety), Black currant (leading Orloviya variety), raspberry (Balzam is leading).The lowest value of soluble solids was observed in strawberry varieties Kama. Analyze berries and fruits differ in the content of organic acids slightly. The maximum content of sugars in apricot, and the minimum for black currant. In the studied fruits, the highest content of phenols was recorded in the black currant. The varieties of flavonoids are different: strawberry Festivalaya, black currant Perun, apricot Khabarovskiy and raspberry Balzam. Low results showed apricot (grade Krugly, Pogremok). The high antioxidant activity was shown by the raspberry varieties Lyubetovskaya and Balzam. The chemical composition and antioxidant activity of fruits and berries play an important role not only for the human body, but also for the technological process during their processing. For this reason, analysis of the feedstock is an important stage in the development and manufacture of food products with a directed antioxidant effect.
Investigation of melting and crystallization processes of fat components of praline masses
Authors: Saranov I. A. , Kuznetsov I. A. , Kuznetsova I. V. , Magomedov G. O. 
Published: October 2018

The processes of melting and crystallization of lauric fat KS35 and coconut oil by the method of differential scanning calorimetry were studied. The process of crystallization of coconut oil takes place in the temperature range 13.1–15.9 °C, while heat is released 118.3 J/g. The process of crystallization of lauric fat KS35 occurs in the temperature range 20.4–25.9 °C, with a heat release of 152.7 J / g. Lauric fat melts in the range of 28.7–33.9 °C, 147.4 J/g is absorbed during this endothermic reaction. Temperature interval, the heat effect of melting coconut oil is lower (18.3–26.4 °C, 95.5 J / g). Reduction of melting and crystallization temperatures of coconut oil in comparison with lauric fat proves that the composition of coconut oil includes a greater number of unsaturated acids, the crystallization and melting of which occurs at a lower temperature than saturated ones.In the paper, the possibility is of using DSC data for determining optimal parameters for forming and cutting praline masses in the production of praline candies. Forming should be done after holding the praline mass in the temperature range 20-26 °C, with most of the triglycerides of lauric fat having a solid state, which allows the molded praline tow to keep its shape and not spread after exiting the matrix. It is advisable to cut praline tows on candies at a temperature of 13 – 16 °C, since in this range most of the triglycerides and coconut oil have a solid state, which makes it possible not to crush the tourniquet and sweets during cutting..
Analysis of the organizations accounts payable of the Kalmykia Republic
Authors: Sarunova M. P. , Burlutkin T. V. , Sandzhieva T. Z. 
Published: October 2018

The article shows the organizationsaccounts payableof the Republic of Kalmykia as one of the most important elements of financial analysis as a separate organization, industry and the whole region. The dynamic changes in accounts payable on the basis of statistical datawere analyzed. It was revealed that the vast majority of overdue accounts payable was formed in housing and communal services. We carried outthe structural analysis of overdue debt composition and revealed the ways of its control. In order to identify the most "vulnerable" areas of economic activity from non-payment, the share of overdue debt to the total amount of debt by industry was considered. To assess the timeliness of payments of enterprises on obligations and the quality of accounts payable, we performed the analysis of the share of overdue accounts payable in its total volume. On thatbasiswe found out the approaches to optimizing the management of accounts payable, leading to the growth of financial results and further development of the economy of the Republic of Kalmykia. To analyze financial stability, it is important to consider not only the status of accounts payable, but also the ratio of accounts receivable to accounts payable. The analysis showed that the proportion is irrational; it is obvious that companies have attracted significant borrowed resources, but currently use of them in their current activitiesinefficient. The article concludes that the financial situation of enterprises and organizations of the region is extremely unstable when there is an annual growth of accounts payable and accounts receivable. In order to stabilize the financial condition of enterprises and organizations of the Republic of Kalmykia, improve their solvency and strengthen the settlement and payment discipline we explored the possibility of restructuring of accounts payable, which requires an analysis of each creditor separately, including all components of the debt-principal amount, interest and penalties.
ARTEFAK DALAM KONTEKS PERKEMBANGAN KAWASAN HERITAGE ISLAM
Authors: Tucunan Karina Pradine , Sulistyandari Utari , Perkasa M Ilham 
Published: October 2018

ABSTRACTIslam is the majority religion in Indonesia, but unfortunately none of the historic sites of Islam in Indonesia became a common concern in the international world. The heritage of Islamic culture is a unique heritage because there is a process of acculturation and change of civilization in a fairly fast time (50 years) from the Hindu-Buddhist kingdom to the Islamic kingdom. Islamic cultural heritage so far only focusing in the existence of mosques and tombs and not focusing in spatial management. This indicates that there is a gap of knowledge on the disciplines of archeology and spatial planning, especially in the management of cultural heritage that should be a multi-disciplinary domain.The methods used in this study is qualitative studywith focus on building a spatial and archeology approaches to the heritage management. With the aim of space categorization and also the types of artifacts available, this paper finds that artifacts are divided into two namely those found or located in the core area and those in the supporting area.Keyword: Islamic Heritage, Artifacts ABSTRAKIslam merupakan agama mayoritas di Indonesia, namun sayangnya tidak satupun situs bersejarah islam menjadi concern bersama dalam dunia Internasional. Warisan kebudayaan islam merupakan sebuah warisan yang unik karena terjadi proses akulturasi dan perubahan peradaban dala waktu yang cukup cepat (50 tahun) dari kerajaan Hindu-Budha menjadi kerajaan Islam Kawasan cagar budaya dalam pengelolaan cagar budaya kawasan islam selama ini hanya teridentifikasi pada keberadaan masjid dan makam. Hal ini mengindikasikan bahwa adanya kesenjangan pengetahuan terhadap disiplin ilmu arkeologi dan perencanaan ruang, terutama dalam pengelolaan cagar budaya yang seharusnya menjadi ranah multi disiplin ilmu. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan menggunakan pengamatan tersetruktur dan konten analisis yang difokuskan pada data-data sekunder (literature review) yang menggabungkan antara ilmu arkeologi dan keruangan (spasial). Dengan tujuan dari kategorisasi ruang dan juga jenis artefak yang ada, makalah ini menemukan bahwa artefak terbagi atas dua yakni yang ditemukan atau berada di Kawasan inti dan yang berada di kawasan pendukung.Kata Kunci:Warisan Kebudayaan Islam, Artefak
Implementasi Sistem Asset Manajemen Sebagai Penunjang Operasional Laboratorium Komputer
Authors: Oktavia Tanty 
Published: October 2018

Currently most organization have assets to support operational processes. Although a number of organizations tend to use outsourcing and leasing services to organize their assets, but some organization prefer to buy their own and manage their assets with a particular reason. Asset management is not a simple job. It’s very difficult to manage assets without information systems as support media. Integrating asset management into information system can help organization to record and update the status of assets, maintenance and repair of assets, calculate asset depreciation, and asset reallocation among divisions. ABC as part of the computer laboratory at a well known University in Jakarta is currently had many problems to manage their assets. The composition of their assets consists of hardware, software, and other supporting devices. Based on these problems, the research carried out in order to solve the problem. The research perform an analysis of the process in asset management as well as to formulate and implement a model of information system that can support the management of existing assets, so that all data can be integrated and managed with the system. The method for this research is based on analysis and design of object-oriented. The result of this research is an asset management system to support operational process that can be used to control all the assets that exist in the computer laboratory
Keywords: asset management, information system, computer laboratory
Numerical Simulation of Three Phase Displacement Characteristics of Foam Fluid In Homogeneous Porous Media
Authors: Du D.X , Zhang D. 
Published: October 2018

Foam technology has found wide applications in enhanced oil recovery and greenhouse geological storage. In this paper, a numerical simulate is carried out with the stochastic bubble population balance model on the foam three phase displacement process in a homogeneous oil/water/gas coexistence porous media of liquid. The effects of the maximum equilibrium bubble density nmax and the foam generation rate Kg on foam displacement process is mainly discussed. Numerical results indicate that the oil phase can be displaced well by foam fluid. Larger nmax values lead to higher apparent viscosity of foam and higher the pressure difference, and with the increase of Kg, the number of foam can reach a balance in a short distance, so it has better displacement effect on the oil phase components. The results obtained in this paper have a certain guiding role in understanding the enhanced oil recovery mechanism of foam fluid.
Designing seryl‐tRNA synthetase for improved serylation of selenocysteine tRNAs
Authors: Fu Xian , Crnković Ana , Sevostyanova Anastasia , Söll Dieter 
Published: October 2018

Selenocysteine (Sec) lacks a cognate aminoacyl‐tRNA synthetase. Instead, seryl‐tRNA synthetase (SerRS) produces Ser‐tRNASec, which is subsequently converted by selenocysteine synthase to Sec‐tRNASec. Escherichia coli SerRS serylates tRNASec poorly; this may hinder efficient production of designer selenoproteins in vivo. Guided by structural modelling and selection for chloramphenicol acetyltransferase activity, we evolved three SerRS variants capable of improved Ser‐tRNASec synthesis. They display 10‐, 8‐, and 4‐fold increased kcat/KM values compared to wild‐type SerRS using synthetic tRNASec species as substrates. The enzyme variants also facilitate in vivo read‐through of a UAG codon in the position of the critical serine146 of chloramphenicol acetyltransferase. These results indicate that the naturally evolved SerRS is capable of further evolution for increased recognition of a specific tRNA isoacceptor.
Concordance with NCCN treatment guidelines: Relations with health care utilization, cost, and mortality in breast cancer patients with secondary metastasis
Authors: Rocque Gabrielle B. , Williams Courtney P. , Kenzik Kelly M. , Jackson Bradford E. , Azuero Andres , Halilova Karina I. , Ingram Stacey A. , Pisu Maria , Forero Andres , Bhatia Smita 
Published: October 2018

BackgroundThe impact of National Comprehensive Cancer Network (NCCN) treatment guideline concordance on costs, health care utilization, and mortality for patients with breast cancer and secondary metastases is unknown.MethodsFrom 2007 to 2013, women with early‐stage breast cancer who received treatment for secondary metastases (n = 5651) were evaluated for first recorded systemic therapy concordance with NCCN guidelines within the Surveillance, Epidemiology, and End Results Program–Medicare linked database. Generalized linear and mixed effects models evaluated factors associated with nonconcordance and the relation between concordance status and health care utilization and costs. Mortality risk was estimated with Cox regression.ResultsEighteen percent of the patients received nonconcordant therapy, with the most common being single‐agent, human epidermal growth factor receptor 2 (HER2)–targeted therapy (36%), therapy mismatched with the estrogen receptor/HER2 status (11%), unapproved bevacizumab regimens (10%), and adjuvant regimens in a metastatic setting (6%). A younger age, a hormone receptor–negative status, and a HER2‐positive status were associated with nonconcordance (P < .05). Nonconcordance was associated with 22% and 21% increased rates of emergency department visits and hospitalizations, respectively, and $1765 higher average monthly Medicare costs. Differences in adjusted mortality risk were noted by the category of nonconcordance; single‐agent, HER2‐targeted therapy was associated with decreased mortality risk (hazard ratio [HR], 0.66; 95% confidence limit [CL], 0.57‐0.76), and increased mortality risk was observed with unapproved bevacizumab use (HR, 1.40; 95% CL, 1.13‐1.74).ConclusionsMost patients (82%) received treatment consistent with NCCN guidelines. Nonconcordant treatment was associated with higher health care utilization and costs, with mortality differences observed by the type of guideline deviation. Consideration of both patient and financial outcomes will be important as health systems increase the emphasis on guideline‐based care.
Prey exploitation and dispersal strategies vary among natural populations of a predatory mite
Authors: Revynthi Alexandra M. , Egas Martijn , Janssen Arne , Sabelis Maurice W. 
Published: October 2018

AbstractWhen predators commonly overexploit local prey populations, dispersal drives the dynamics in local patches, which together form a metapopulation. Two extremes in a continuum of dispersal strategies are distinguished: the “Killer” strategy, where predators only start dispersing when all prey are eliminated, and the “Milker” strategy, in which predator dispersal occurs irrespective of prey availability. Theory shows that the Milker strategy is not evolutionarily stable if local populations are well connected by dispersal. Using strains of the predatory mitePhytoseiulus persimilis, collected from 11 native populations from coastal areas in Turkey and Sicily, we investigated whether these two strategies occur in nature. In small wind tunnels, we measured dispersal rates and population dynamics of all populations in a system consisting of detached rose leaves, spider mites (Tetranychus urticae) as prey, andP. persimilis. We found significant variation in the exploitation and dispersal strategies among predator populations, but none of the collected strains showed the extreme Killer or Milker strategy. The results suggest that there is genetic variation for prey exploitation and dispersal strategies. Thus, different dispersal strategies in the Milker–Killer continuum may be selected for under natural conditions. This may affect the predator–prey dynamics in local populations and is likely to determine persistence of predator–prey systems at the metapopulation level.
Microdroplet monitoring using microfluid circuit combined quartz oscillator based capacitive sensor
Authors: Ebata Ryo , Sakai Ryo , Sohgawa Masayuki , Abe Takashi 
Published: October 2018

AbstractIn this article, we developed a compact microdroplet monitoring sensor. This sensor is capacitive sensor combined a microfluidic circuit and a crystal oscillator. We succeeded in the generation and monitoring of microdroplets with this sensor. We optimized the sensing capacitor to improve the sensitivity of the sensor. With optimized the sensing capacitor, the frequency response can be increased. We measured NaCl aqueous solution concentration with the optimized sensing capacitor. From the measurement result, the high dynamic range measurement can be made by using two frequencies.