bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thyroid Cancer Patients With No Evidence of Disease: The Need for Repeat Neck Ultrasound
Authors: Grani Giorgio , Ramundo Valeria , Falcone Rosa , Lamartina Livia , Montesano Teresa , Biffoni Marco , Giacomelli Laura , Sponziello Marialuisa , Verrienti Antonella , Schlumberger Martin , Filetti Sebastiano , Durante Cosimo 
Published: June 2019

Abstract

Context
Ultrasonography (US) is considered the most sensitive tool for imaging persistent or recurrent papillary thyroid cancer (PTC) in the neck.

Objective
To clarify the usefulness of routine neck US in low- and intermediate-risk patients with PTC with no evidence of disease 1 year after thyroidectomy.

Design
Retrospective analysis of prospectively recorded data.

Setting
Academic center.

Patients
Two hundred twenty-six patients with PTC with sonographically normal neck lymph nodes and unstimulated serum thyroglobulin (Tg) levels that were either undetectable (<0.20 ng/mL) or low (0.21 to 0.99 ng/mL) at the 1-year evaluation.

Interventions
Yearly assessment: unstimulated serum Tg level, anti-Tg-antibody (TgAb) titer, TSH levels, and ultrasound examination of neck lymph nodes.

Main Outcome Measures
Rates of ultrasonographic lymph node abnormalities at the 3-year and last follow-up visits.

Results
In patients with an undetectable Tg level at the 1-year evaluation, sonographically suspicious neck lymph nodes were found in 1.2% of patients at 3 years and in 1.8% at the last visit [negative predictive values (NPVs) of 1-year Tg < 0.2 ng/mL: 98.8% (95% CI 95.8% to 99.9%) and 98.2% (95% to 99.6%), respectively]. Similar NPVs emerged for low detectable 1-year Tg levels [98.2% (90.3% to 99.9%) and 94.5% (84.9% to 98.9%) at the 3-year and last visits, respectively]. Seventy-five percent of the nodal lesions were likely false positive; none required treatment.

Conclusions
Low- and intermediate-risk patients with PTC with negative ultrasound findings and unstimulated Tg levels <1 ng/mL at the 1-year evaluation can be safely followed with clinical assessments and unstimulated serum Tg determinations. Neck US might be repeated if TgAb titers rise, or unstimulated Tg levels exceed 1 ng/mL.
Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain
Authors: You Zerong , Ding Weihua , Doheny Jason T. , Shen Shiqian , Yang Jinsheng , Yang Liuyue , Chen Lucy , Zhu Shengmei , Mao Jianren 
Published: June 2019

BACKGROUND:
The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction. Central dopamine (DA) dysfunction contributes to the chronicity of pain and a decreased opioid analgesic effect. Methylphenidate (MPH/Ritalin) enhances central DA function by inhibiting DA reuptake. In this study, we used a rat model of chronic pain to examine whether combination of MPH with morphine (MOR) would improve the MOR analgesic effect under a chronic pain condition.

METHODS:
Tibiotarsal joint Complete Freund’s Adjuvant (CFA) injection in rats was utilized to induce chronic nociception. The analgesic effect of low-dose MPH (0.25 mg/kg), low-dose MOR (2.5 mg/kg), and their combination was examined in CFA rats. Nociceptive behavior was assessed by von Frey test. Conditioned place preference (CPP) and open field tests (OFTs) were used to examine the rewarding behavior and locomotor activity in rats, respectively.

RESULTS:
Our findings are as follows: (1) in CFA rats with chronic pain, 2.5 mg/kg of MOR had less analgesic effect than 10 mg/kg of MOR at 28 days after injury (95% confidence intervals [CIs] for difference of means of von Frey threshold in gram: −11.9 [−6.5 to −17.3]); (2) in the 1-hour time window of 30–90 minutes after injection, the combination of MPH (0.25 mg/kg) with MOR (2.5 mg/kg) increased synergistically and prolonged the analgesic effect in CFA rats as compared with MPH or MOR alone (P = .01 for MPH by MOR interaction, and 95% CIs for difference of means of von Frey threshold in gram: 3.3 [1.37–6.12] for the combination versus MPH and 3.2 [1.35–5.74] for the combination versus MOR); (3) at the low dose (0.25 mg/kg), MPH did not increase locomotor activity (MOR + MPH versus MOR, P = .13) nor significantly enhanced MOR reward behavior (MOR + MPH versus MOR, P = .63) in CFA rats.

CONCLUSIONS:
Our data suggest that a combination therapy using low-dose MPH and MOR may produce a MOR-sparing effect in chronic pain management.
Proximity labeling reveals novel interactomes in live Drosophila tissue
Authors: Mannix Katelynn M. , Starble Rebecca M. , Kaufman Ronit S. , Cooley Lynn 
Published: June 2019

ABSTRACT
Gametogenesis is dependent on intercellular communication facilitated by stable intercellular bridges connecting developing germ cells. During Drosophila oogenesis, intercellular bridges (referred to as ring canals; RCs) have a dynamic actin cytoskeleton that drives their expansion to a diameter of 10 μm. Although multiple proteins have been identified as components of RCs, we lack a basic understanding of how RC proteins interact together to form and regulate the RC cytoskeleton. Thus, here, we optimized a procedure for proximity-dependent biotinylation in live tissue using the APEX enzyme to interrogate the RC interactome. APEX was fused to four different RC components (RC-APEX baits) and 55 unique high-confidence prey were identified. The RC-APEX baits produced almost entirely distinct interactomes that included both known RC proteins and uncharacterized proteins. A proximity ligation assay was used to validate close-proximity interactions between the RC-APEX baits and their respective prey. Furthermore, an RNA interference screen revealed functional roles for several high-confidence prey genes in RC biology. These findings highlight the utility of enzyme-catalyzed proximity labeling for protein interactome analysis in live tissue and expand our understanding of RC biology.
Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance
Authors: Otto Georg W. , Kaisaki Pamela J. , Brial Francois , Le Lay Aurélie , Cazier Jean-Baptiste , Mott Richard , Gauguier Dominique 
Published: June 2019

ABSTRACT
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes and normoglycaemic Brown Norway (BN) rats. We mapped 2526 statistically significant expression quantitative trait loci (eQTLs) in the cross. More than 40% of eQTLs mapped in the close vicinity of the linked transcripts, underlying possible cis-regulatory mechanisms of gene expression. We identified eQTL hotspots on chromosomes 5 and 9 regulating the expression of 80-165 genes, sex or cross direction effects, and enriched metabolic and immunological processes by segregating GK alleles. Comparative analysis with adipose tissue eQTLs in the same cross showed that 496 eQTLs, in addition to the top enriched biological pathways, are conserved in the two tissues. Extensive similarities in eQTLs mapped in the GK rat and in the spontaneously hypertensive rat (SHR) suggest a common aetiology of disease phenotypes common to the two strains, including insulin resistance, which is a prominent pathophysiological feature in both GK rats and SHRs. Our data shed light on shared and tissue-specific molecular mechanisms that might underlie aetiological aspects of insulin resistance in the context of spontaneously occurring hyperglycaemia and hypertension.
Subtle short-term physiological costs of an experimental augmentation of fleas in wild Columbian ground squirrels
Authors: Roth Jeffrey D. , Dobson F. Stephen , Criscuolo François , Uhlrich Pierre , Zahariev Alexandre , Bergouignan Audrey , Viblanc Vincent A. 
Published: June 2019

ABSTRACTParasites affect many aspects of host physiology and behavior, and thus are generally thought to negatively impact host fitness. However, changes in form of short-term parasite effects on host physiological markers have generally been overlooked in favor of fitness measures. Here, we studied flea (Oropsylla idahoensis and Oropsylla opisocroistis tuberculata) parasitism on a natural population of Columbian ground squirrels (Urocitellus columbianus) in Sheep River Provincial Park, AB, Canada. Fleas were experimentally added to adult female U. columbianus at physiologically demanding times, including birth, lactation and weaning of their young. The body mass of adult females, as well as their oxidative stress and immunity were recorded multiple times over the active season under flea-augmented and control conditions. We also measured the prevalence of an internal parasite (Trypanosoma otospermophili). Doubly labeled water (DLW) was intra-peritoneally injected at peak lactation to examine energy expenditure. Effects of parasites on oxidative stress were only observed after offspring were weaned. There was no direct effect of experimentally heightened flea prevalence on energy use. A short-term 24 h mass loss (−17 g) was detected briefly after parasite addition, likely due to U. columbianus preferentially allocating time for grooming. Our parasite augmentation did not strongly affect hosts and suggested that short-term physiological effects were unlikely to culminate in long-term fitness consequences. Columbian ground squirrels appear to rapidly manage parasite costs, probably through grooming.
A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa
Authors: Frew John W. , Hawkes Jason E. , Krueger James G. 
Published: June 2019

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with significant morbidity and impact on quality of life. Our understanding of the pathophysiology is incomplete, impairing efforts to develop novel therapeutic targets. Immunohistochemistry studies have produced conflicting results and no systematic evaluation of study methods and results has been undertaken to date. Methods: This systematic review aimed to collate and describe all reports of immunohistochemical staining in HS. This systematic review was registered with PROSPERO and conducted in line with the PRISMA reporting guidelines. Potential bias was assessed using the NIH Criteria and antibodies used across various studies were tabulated and compared. Results: A total of 22 articles were identified describing results from 494 HS patients and 168 controls. 87 unique immunohistochemical targets were identified. The overall quality of studies was sub-optimal with staining intensity confounded by active treatment. Conflicting data was identified and able to be reconciled through critical evaluation of the study methodology. Conclusions: Keratinocyte hyperplasia with loss of cytokeratin markers co-localizes with inflammation comprising of dendritic Cells, T-lymphocytes and macrophages, which are known to play central roles in inflammation in HS. Primary follicular occlusion as a pathogenic paradigm and the principal driver of HS is unclear based upon the findings of this review. Inflammation as a primary driver of disease with secondary hyperkeratosis and follicular occlusion is more consistent with the current published data.
HIV prevalence correlated with circumcision prevalence and high-risk sexual behavior in India's states: an ecological study
Authors: Kenyon Chris R. 
Published: June 2019

Background:HIV prevalence varies between 0% and 1.6% in India's states. The factors underpinning this variation are poorly defined.Methods:We evaluated the relationship between HIV prevalence by state and a range of risk factors in the Indian 2015 National Family Health Survey. Pearson’s correlation was used to assess the relationship between HIV prevalence and each variable. The prevalence of each risk factor was compared between five high-HIV-prevalence states (>1% prevalence) and a large low-HIV-prevalence state (Uttar Pradesh; HIV prevalence, 0.06%).Results:There was an association between HIV prevalence and men's mean lifetime number of partners (r = 0.55; P = 0.001) and men reporting sex with a non-married, non-cohabiting partner (r = 0.40; P = 0.014). In general, men in high-prevalence states were less likely to be circumcised and (with the exception of Chandigarh) use condoms at last sex. In two high prevalence states (Mizoram and Nagaland), men reported a higher number of lifetime partners and a higher prevalence of multiple partners and high-risk sex in the past year.Conclusions:Variation in circumcision prevalence and sexual behavior may contribute to the large variations in HIV prevalence by state in India.
Age, prostate volume, prostate-specific antigen and prostate-specific antigen density as predictor factors in results of transrectal ultrasonography-guided prostate biopsy
Authors: Putra Prima Ciko Ade , Umbas Rainy , Hamid Agus Rizal Ardy Hariandy , Mochtar Chaidir Arif 
Published: June 2019

Background: To identify the predictor factors, such as prostate-specific antigen (PSA), age, prostate volume (PV), and PSA density (PSAD) as indications to perform transrectal ultrasonography (TRUS)-guided prostate biopsy in reducing unnecessary biopsies and improving detection rate. Methods: A total of 1232 samples were obtained from the medical records of patients underwent prostate biopsy from January 2008 to December 2013 in Cipto Mangunkusumo Hospital Jakarta. Pre-biopsy data including age, PSA, prostate volume, and PSAD were obtained. The Mann-Whitney U-test and unpaired t-test were conducted on the quantitative variables; a chi-square test was used for qualitative variables. This study also conducted receiver operating characteristic (ROC) curve analysis to determine the cut-off point and the optimum specificity and sensitivity for each variable. Results: Among 1232 patients, 33.5% had a positive biopsy result. The median age and PSA (68 years and 57.45 ng/ml) in the positive biopsy group was higher than in the negative group (65 years and 11.69 ng/ml), p <0.001. PSAD in patients with PSA 4-10 ng/ml, 10-20 ng/ml, and 20 ng/ml (0.20, 0.35, 2.05) in positive group was higher than negative group (0.14, 0.24, 0.53), p <0.001. Those with a positive biopsy result had a lower median PV (42 ml (range, 13.8-208)) compared to those with negative biopsies (55.4 ml) (p <0.001). In ROC curve, PSAD had the highest sensitivity and specificity (81.4% and 82.0%) with a cut-off point of 0.43 ng/ml/ml (p <0.001). Conclusion: The incidence of PCa increased with higher PSA level, older age and lower PV. Utilization of PSAD 0.17 ng/ml/ml as a cut-off point in patients with PSA level between 4-10 ng/ml is recommended to improve PCa detection in Indonesian men.
Screening tuberculosis patients for diabetes mellitus in a routine program setting in Kampala, Uganda: a cross-sectional study
Authors: Nsonga Joseph , Dongo John Paul , Mugabe Frank , Mutungi Gerald , Walyomo Richard , Oundo Christopher , Zalwango Sarah , Okello Daniel , Muchuro Simon , Dlodlo Riitta A , Lin Yan 
Published: June 2019

Background: Uganda is located in East Africa and is among the countries with the lowest income globally. The ten health centres in this project serve populations in the under-privileged communities of Kampala. The objective of the study was to implement diabetes mellitus (DM) screening among tuberculosis (TB) patients in a routine program setting with limited resources and high human immunodeficiency virus (HIV) prevalence. Methods: A descriptive cross-sectional observational study was conducted in ten health centres in Kampala, Uganda. As part of a project to implement DM screening in a routine setting, TB patients were screened for DM by trained health workers. A fasting blood glucose (FBG) value ≥7.0mmol/l was considered to indicate DM. For this study, aggregate data was collected and analysed using SPSS for Windows, version 13.0. Results: Among 4,590 TB patients registered, 4,016 (88.0%) were screened with random blood glucose (RBG). Of those with RBG ≥6.1mmol/l, 1,093 (83.3%) were screened with FBG. In total, 92 (2.3%) patients were diagnosed with DM and 66 (71.8%) of them were newly diagnosed. The proportion of TB patients screened with FBG in the health centres varied from 58.2% to 100%. The proportion of patients screened with FBG and the prevalence of DM were significantly higher in private health centres compared with public health centres. The health centres in peri-urban areas screened more patients with RBG than those in urban areas. Health centres without DM services screened a larger number of patients with RBG and FBG than those with DM services. Conclusions: It appears feasible to implement screening TB patients for DM in routine program settings with limited resources and high HIV prevalence. Its introduction requires close collaboration between TB and DM services. The challenges identified need government attention and certain institutional and service-related factors need to be better managed at times.
H-bonded Chains and Networks: A Recurring Feature in the Solid State Structures of Manganese (III) Carboxylate Schiff Base Complexes
Authors: Sasi Biny , S Swathy , V S Thampidas , Robert Pike D 
Published: June 2019

Two new manganese(III) Schiff base complexes, [Mn(salen)(m-NO2-C6H4CO2)(H2O)] (1) and [Mn(msalen) (p-OH-C6H4CO2)(H2O)] (2), where H2salen = N,N'-bis(salicylidene)-1,2-diaminoethane, H2msalen = N,N'-bis (3-methoxysalicylidene)-1,2-diaminoethane were synthesized from the manganese (II) carboxylates. Single crystal X-ray diffraction studies show that the Jahn-Teller distorted octahedral complexes are stabilized by H-bonded chains and networks in the solid state.
Sterol Composition of the Indian Green Lipped Mussel Perna virdis
Authors: Anuradha V , Vineetha P V , Amruta Mano , Stephy P S , Byju K , Shameem K , Vasundhara G , Kuma N C , Nair S M 
Published: June 2019

Sterol composition of green lipped mussel Perna virdis was analysed using GCMS. Cholesterol was found to be the dominant sterol (54.162% of the total sterol content). Other sterols such as Cholesta-5,22-dien-3-ol (3β), ergosta-5,22-dien-3-ol (3 β,22E, 24S), 26,26-dimethyl-5,24 (28)-Ergostadien-3β-ol, 26-nor-5cholesten- 3β-ol, stigmasterol and γ sitosterol were also detected. Presence of phytosterols like stigmasterol and γ sitosterol underlines high nutritional potential and food value of this bivalve mollusk.
Synthesis of a New Series of Quinolinoxymethylcoumarins as Potent Anticancer Agents
Authors: Shamala D , Shivashankar K , Vijaykumar Rasal P , Vineela Pandi 
Published: June 2019

4-Bromomethylcoumarins (1a-f) were reacted with 8-hydroxyquinoline to yield quinolinoxymethylcoumarins (2a-f). The structure of all the synthesized compounds were confirmed by spectral studies and screened for their anticancer activities against Dalton’s Ascitic lymphoma (DAL) and Ehrlich Ascites Carcinoma (EAC) cell lines. Out of these, compound (2b) (R = 6-OMe) was found to be the most potent cytotoxic compound against DAL and EAC cell lines.
Gradient on Rayleigh–Bénard – Marangoni – Magnetoconvection in a Micropolar Fluid with Maxwell – Cattaneo Law
Authors: Kiran R V , Kalyani Attluri 
Published: June 2019

The effect of non-uniform temperature gradient on the onset of Rayleigh-Bénard-Marangoni- Magneto-convection in a Micropolar fluid with Maxwell-Cattaneo law is studied using the Galerkin technique. The eigen value is obtained for rigid-free velocity boundary combination with isothermal and adiabatic condition on the spin-vanishing boundaries. A linear stability analysis is performed. The influence of various parameters on the onset of convection has been analyzed. One linear and five non-linear temperature profiles are considered and their comparative influence on onset is discussed. The classical approach predicts an infinite speed for the propagation of heat. The present non-classical theory involves a wave type heat transport (Second Sound) and does not suffer from the physically unacceptable drawback of infinite heat propagation speed.
Cu(II), Cd(II) and Ni(II) Complexes of 5-Bromosalicylaldehyde-4-hydroxybenzhydrazone: Synthesis and Spectral Studies
Authors: Reji Geo , Amrutha P S , Greeshma M R , Tom Lincy , Kurup M R P 
Published: June 2019

Four complexes of 5-bromosalicylaldehyde-4-hydroxybenzhydrazone were synthesized and characterized by elemental analyses, electronic, and infrared spectra. In all complexes, hydrazone exists either in the neutral form, deprotonated monoanionic form or in dideprononated dianionic form. Structures were assigned to all the complexes based on the physico-chemical studies.
Editorial: un nuevo periodo en la revista Avances en Psicología Latinoamericana (2016-2020)
Authors: Gutierrez-Peláez Miguel , Ramírez Luisa Fernanda 
Published: June 2019

La revista Avances en Psicología Latinoamericana ingresa en una nueva etapa. Durante el periodo 2016-2020 asumiremos Miguel Gutiérrez-Peláez como director y Luisa Fernanda Ramírez como editora general. En su último editorial, AndrésPérez-Acosta y Gladys Martínez (2015) presentaron de manera clara la historia de esta revista y los logros alcanzados durante su gestión. Los retos para el nuevo equipo editorial no son pocos; pero con el apoyo, el impulso y la orientación que losequipos anteriores le han dado a la revista, asumimos la misión de seguir posicionándola como un referente de consulta científica para el gremio de la psicología en Latinoamérica y en el mundo.
Un arte con machete. Comentario sobre la obra de Alonso Jiménez
Authors: Gutierrez-Peláez Miguel 
Published: June 2019

Con Alonso Jiménez hemos podido conversar sobre la anécdota que trae Umberto Eco a propósito del retrato que le realiza Pablo Picasso a la poeta estadunidense Gertrude Stein. Terminando el retrato, un observador lo increpa y le dice: “Perono se parece”, a lo que Picasso responde: “Pero se parecerá”. Hay múltiples efectos que se extraen de esta anécdota. Por un lado, el más evidente, es que nadie se acordará de cómo era Gertude Stein, pero todos podremos tener clara la imagen del retrato que hizo de ella Picasso.
A Short-Term Intervention for Adolescents with Callous-Unemotional Traits and Emotion-Processing Deficits
Authors: Lui Joyce H. L. , Barry Christopher T. , Marcus David K. 
Published: June 2019

Introduction: Research documents a robust relation between callous-unemotional (CU) traits and impairments in emotion-processing in youth, yet few evidence-based treatments targeting these deficits exist for youth with CU traits. This study examined a novel Emotion-Processing Skills Training (EPST) to target emotion recognition and perspective-taking deficits in adolescents with CU traits through an additive design. Methods: Fifty-six adolescents (Mage = 16.54, SD = .57, 83.9% male, 67.9% White/Caucasian) attending a voluntary residential program received treatment as usual (TAU) or the EPST intervention plus TAU (EPST + TAU) in a partially randomized trial. Assessments were conducted at four time-points, and they involved adolescent-, parent-, peer-, and staff-report. Outcomes of interest included emotion recognition, perspective-taking, CU traits, empathy, prosocial behaviors, social problems, and externalizing problems. Results: Participants who received EPST significantly improved more on perspective-taking at post-treatment than those who only received TAU. Those who only received TAU significantly declined on self-reported empathy and prosocial behaviors from baseline to 12-week follow-up, but those who received EPST declined less or had minimal change. Participants across conditions improved on self-reported CU traits, social problems, and externalizing problems and parent-reported CU traits, social problems, and externalizing problems across time. Discussion: The EPST intervention yielded largely comparable changes to TAU, but in some cases, EPST may have buffered participants from decline in their affective, social, and behavioral functioning. Implications for treatment of adolescents with CU traits are discussed.