bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Sequencing Expansion and Incomplete Penetrance
Authors: Shieh Joseph T.C. 
Published: January 2019

BACKGROUND:
Genetic data have the potential to impact patient care significantly. In primary care and in the ICU, patients are undergoing genetic testing. Genetics is also transforming cancer care and undiagnosed diseases. Optimal personalized medicine relies on the understanding of disease penetrance. In this article, I examine the complexity of penetrance.

METHODS:
In this article, I assess how variable penetrance can be seen with many diseases, including those of different modes of inheritance, and how genomic testing is being applied effectively for many diseases. In this article, I also identify challenges in the field, including the interpretation of gene variants.

RESULTS:
Using advancing bioinformatics and detailed phenotypic assessment, we can increase the yield of genomic testing, particularly for highly penetrant conditions. The technologies are useful and applicable to different medical situations.

CONCLUSIONS:
There are now effective genome diagnostics for many diseases. However, the best personalized application of these data still requires skilled interpretation.
Current Pharmacotherapy Does Not Improve Severity of Hypoactive Delirium in Patients with Advanced Cancer: Pharmacological Audit Study of Safety and Efficacy in Real World (Phase-R)
Authors: Okuyama Toru , Yoshiuchi Kazuhiro , Ogawa Asao , Iwase Satoru , Yokomichi Naosuke , Sakashita Akihiro , Tagami Keita , Uemura Keiichi , Nakahara Rika , Akechi Tatsuo ,   on behalf of Phase-R Delirium Study Group
Published: January 2019

Abstract

Background
Pharmacotherapy is generally recommended to treat patients with delirium. We sought to describe the current practice, effectiveness, and adverse effects of pharmacotherapy for hypoactive delirium in patients with advanced cancer, and to explore predictors of the deterioration of delirium symptoms after starting pharmacotherapy.

Subjects, Materials, and Methods
We included data of patients with advanced cancer who were diagnosed with hypoactive delirium and received pharmacotherapy for treatment of delirium. This was a pharmacovigilance study characterized by prospective registries and systematic data-recording using internet technology, conducted among 38 palliative care teams and/or units. The severity of delirium and other outcomes were assessed using established measures at days 0 (T0), 3 (T1), and 7 (T2).

Results
Available data were obtained from 218 patients. The most frequently used agent was haloperidol (37%). A total of 67 and 42 patients (31% and 19%) had died or discontinued pharmacotherapy by T1 and T2, respectively. Delirium symptoms deteriorated between T0 and T1, but this trend did not reach statistical significance. The most prevalent adverse event was sedation (9%). Delirium severity worsened after starting pharmacotherapy in 121 patients (56%) at T1. In patients whose death was expected within a few days and those with delirium caused by organ failure, symptoms of delirium were significantly more likely to deteriorate after starting pharmacotherapy.

Conclusion
Current pharmacotherapy for hypoactive delirium in patients with advanced cancer is not recommended, especially in those whose death is expected within a few days and in those with delirium caused by organ failure.
Anatomical properties of four Pilosella Vaill. (Asteraceae) taxa from Eastern Black Sea Region of Turkey
Authors: Umdu Topsakal Ünsal , Beyazoğlu Osman , Çoşkunçelebi Kamil 
Published: January 2019

Anatomical features of four Pilosella Vaill. taxa (P. officinarum
Vaill., P. piloselloides (Vill.) Sojak subsp. bauhini (Schult.) S. Bräut. &amp; Greuter, P.× hypeurya (Peter) Sojak,
P. densiflora (Tausch) Sojak) collected from Black Sea Region of Turkey
were investigated. Anatomical studies include transverse sections of root, stem
and leaf with their illustrations. Although the anatomical properties are
similar to the typical anatomy of dicotyledons, some differences were observed
among them. While root anatomy of P. officinarum, P. piloselloides subsp. bauhini and P. densiflora consist of a single layer exodermis, there is
2-3 layer exodermis in the natural hybrid P. × hypeurya. Additionaly the
root pith of this hybrid taxa
completely composed of schlerenchyma cells in contrast to other investigated
taxa. The stem anatomy of the investigated taxa is similar to each other except
the number of the tracheidal elements. The numbers of the stomata per µm2 disticltly differ in P. piloselloides subsp. bauhini from the rest examined
taxa.
Participative dendromass bioenergy modeling in regional dialogs with the open-source BEAST system
Authors: Thiele Jan C. 
Published: January 2019

Regional participative decision-making processes are becoming increasingly important in the context of climate change mitigation goals and renewable energy production. Dendromass bioenergy plays an important role in climate protection planning at the local and regional levels.
The 'Bio-Energy Allocation and Scenario Tool' (BEAST) is a decision support system designed to assist in stakeholder dialogues, with the goal of developing scenarios of regional wood production through scenario quantification and visualization. While it incorporates wood from forests and outside of forests as bioenergy sources, its main application area is the spatial selection of preference sites for Short Rotation Coppices on arable land, based on the integration of ecological and economic assessments in a multi-criteria analysis with preference selection using Analytic Hierarchy Process (AHP).
This paper provides a comprehensive overview of the purposes of the system, its simulation and software design, and also announces the system's availability as open-source software.
Türkiye’deki Sosyal Bilgileri Eğitimi Lisans Programlarının Mevcut Durumunun İncelenmesi (2017)
Authors: TOKCAN Halil , TİLKİ Arife 
Published: January 2019

Bu araştırmanın temel amacı Türkiye’deki
Sosyal Bilgiler Eğitimi Anabilim Dallarının 2017 yılındaki mevcut durumunu
ortaya koymaktır. Araştırmada Sosyal Bilgiler Eğitimi Anabilim Dallarında 2017
yılında öğrenim gören öğrenci sayısı, bu anabilim dalında görev yapan öğretim
üyesi sayısı, anabilim dalına kaydolan öğrencilerin puanlarının yıllara göre
ve üniversitelere göre değişimi ve sosyal bilgiler öğretmenliğinin 2013-2017
yılları arası atama sayıları incelenmiştir. Araştırmada nitel araştırma
yöntemlerinden doküman inceleme yöntemi kullanılmıştır. Araştırma verilerini
toplamada anabilim dalındaki öğrenci sayılarını ve programın taban puanlarının
belirlenmesinde son 4 yılın ÖSYM kılavuzunda yer alan bilgiler kullanılırken;
öğretim üyeleri sayısı belirlemede ise ilgili anabilim dallarının internet
sayfaları esas alınmıştır. Araştırma sonuçlarına göre 2017 yılı itibariyle
Türkiye’de toplam 59 üniversitede Sosyal Bilgiler Eğitimi Anabilim Dalı aktif
olarak eğitim-öğretim faaliyeti göstermektedir. LYS kontenjanları esas
alındığında sosyal bilgiler öğretmenliği anabilim dallarında toplam öğrenci
15.639’dur. Sosyal Bilgiler Öğretmenliği anabilim dalının puan sıralarının
oldukça değişken olduğu görülmektedir. 2016 yılında Sosyal Bilgiler
Öğretmenliği programına yerleşen en yüksek puanlı öğrencinin puan sırası
25.800 iken en düşük puanlı öğrencinin sırası 75.900’dür. 2013-2017 yılın verilerine göre sosyal
bilgiler öğretmenliği programına yerleşen en yüksek puanlı öğrencilerin tercih
ettikleri üniversite İstanbul Üniversitesi’dir. Araştırma sonucunda
üniversitelerin sosyal bilgiler öğretmenliği anabilim dalına yerleşen öğrenci
sayısının, atama sayılarına göre çok fazla olduğu bu nedenle atanmayı bekleyen
yaklaşık 27.500 kişi olduğu belirlenmiştir. Atama bekleyen öğrenci sayısının
artması nedeniyle 2015 yılından itibaren ÖABT sosyal bilgiler sınavına giren
aday sayısı git gide azalmaktadır. Çalışma sonuçlarına göre Türkiye’de Sosyal
Bilgiler Eğitimi anabilim dallarının kontenjan sayılarının azaltılırken;
öğretim üyesi sayısının ise arttırılması kalitenin ve gelecek hedeflerinin
tutturulması açısından faydalı olacağı söylenebilir.
Sürdürülebilir Gıda Değer Zinciri Yaklaşımı
Authors: ADANACIOĞLU Hakan , SANER Gamze , AĞIR Hasan Burak 
Published: January 2019

Bir gıda
değer zinciri, gıda ürünlerinin üretilmesi için gerekli olan koordineli üretim
ve katma değerli faaliyetlere katılan tüm paydaşlardan oluşmaktadır. Girdileri
ve kaynakları daha etkin bir şekilde yönetmek açısından gıda değer zincirlerine
sürdürülebilirlik ilkelerinin uygulanması küçük çiftçilerin ve gıda
işletmelerinin daha rekabetçi ve yenilikçi olabilmeleri açısından önemlidir.
Sürdürülebilir gıda değer zinciri çerçevesi, son yıllarda düşünce ve uygulama
açısından kalkınmada popüler duruma gelen sürdürülebilirlik ve değer zincirleri
kavramlarını birleştirmektedir. Değer zincirinin sürdürülebilirliği eş zamanlı
olarak ekonomik, sosyal ve çevresel olmak üzere üç boyutta ortaya çıkmaktadır.
Sürdürülebilir bir gıda değer zinciri; tüm zincir boyunca kar elde edilmesi,
toplum için geniş tabanlı fayda sağlanması ve kalıcı olarak doğal kaynakların
tüketilmemesi esaslarından hareket ederek,
belirli tarımsal hammaddelerin üretilmesi, bu hammaddelerin belirli gıda
maddelerine dönüştürülerek nihai tüketicilere satılması ve bunların atıklarının
bertaraf edilmesi aşamalarında yer alan tüm tarımsal işletmeler ile firmaların
birbirini izleyen koordineli katma değerli faaliyetleri olarak
tanımlanmaktadır. Sürdürülebilir gıda değer zincirinin nihai hedefi, hem mevcut
hem de gelecek nesiller için bir toplumun refahında geniş tabanlı bir
iyileşmeye önemli ölçüde katkıda bulunmaktır. Bu çalışmanın amacı,
sürdürülebilir gıda değer zincirinin çerçevesini ortaya koyarak ekonomik,
sosyal ve çevresel olmak üzere üç boyutta sürdürülebilir değer zinciri için
belirlenen hedefleri açıklamaktır. Çalışmada esas olarak, sürdürülebilir gıda
değer zinciri kapsamında dünyada yapılan bazı örnek girişimler incelenerek
tartışılmış ve bazı öneriler getirilmiştir.
Reconciling ADDIE and Agile instructional design modelsâ€”case study
Authors: Gawlik-Kobylinska MaÅ‚gorzata 
Published: January 2019

Using the model of analysis, design, development, implementation and evaluation (ADDIE) with regards to instructional design has become a prevalent practise among e-learning designers and developers. This model assumes assigning specific roles to project team members and their linear cooperation. However, in case of working in a dynamic and complex environment, the ADDIE model may evolve into more adaptive and people-oriented Agile instructional models. This article analyses a hybrid approach to the process of creating the e-learning course introduction to cultural awareness in specific situational context, which involves a small size of a project team and geographically dispersed project contributors. The case study reveals that a successful accomplishment of multinational projects, conducted in specific environments may require a hybrid approach; moreover, in such atypical projects good communication skills and personal qualities are crucial for goalsâ€™ achievement. The results of qualitative analysis may open further discussions on this topic.

Keywords: ADDIE model, Agile model, e-learning course, instructional design.
Type studentsâ€™ versus academic staffâ€™ attitudes towards e-learning: A comparative study
Authors: Zare-Bidakia Majid , Rajabpour-Sanati Ali , Mousavi Bentolhoda 
Published: January 2019

In developed countries, universities have started e-learning. This phenomenon is a new issue in Iran. This research aimed to investigate studentsâ€™ and faculty membersâ€™ attitude towards electronic learning in Birjand University of Medical Sciences. This is a descriptive-surveying study. Research population includes students and faculty members of Birjand University of Medical Sciences. Data were collected from 313 students and 86 faculty member through a researcher-made questionnaire. Reliability of this questionnaire was obtained 0.91 using alpha Cronbach coefficient. Field study was used to collect the data and the collected data were analysed by SPSS software. Both students and faculty members showed positive attitude towards e-learning. However, faculty members showed more positive view about e-learning (p < 0.000). Our findings showed that there is a significant difference among studentsâ€™ attitudes in different schools about e-learning (p < 0.000). Academic managers should provide requirements to develop e-learning in Iranian universities.

Keywords: E-learning, student, faculty members, attitude.
Reasons for non-critical thinking: The multilevel model approach
Authors: Fabian Gyongyi 
Published: January 2019

In current literature, one is offered a number of ways of discussing critical thinking, and furthermore, authors follow different tracks grounded in a variety of disciplines (philosophical, psychological and educational) to approach the concept. The only consensus within this topic seems to be the claim that there is no consensus concerning the definition and the construct of critical thinking. I propose that the critical thinking is a complex concept, which simultaneously involves components at three levels, at the level of the culture, the individual and the language. I call the resulting framework a multilevel model (MLM) of the critical thinking concept. The paper argues that the study of critical thinking and non-critical thinking instances within the framework of the MLM allows us a better understanding of the phenomena internationally, and in addition, that no one level can be singled out as the only appropriate level of analysis of critical thinking instances.

Keywords: Critical thinking, language, emotion, context, social environment, culture.
Legal clinics, a challenge for the teaching of law
Authors: Mimoso Maria Joao , Anjos Maria do Rosario , Miranda Carlos 
Published: January 2019

The teaching of law has experienced new challenges, especially with globalisation and the changes introduced by the Bologna process. However, it has been difficult to implement them before the insistence of the traditional methodology of expository lessons, deeply rooted in the cycles of law. One of the current challenging methodologies is the legal clinics, as a dynamic and providing tool for active learning and facilitating the acquisition of practical competences. The legal clinics offer the possibility of a teaching based on life cases, allowing students to observe the effective or simulated representation of legal cases, developing skills, also appealing to the values and ethics that are imposed on a future jurist, be a lawyer or a magistrate. The purpose of our study is to raise awareness of the paradigm shift in the teaching of law, especially in Portuguese schools. The legal clinics will raise awareness of civil society, instilling reliability in the legal services.

Keywords: Globalisation, law, legal clinics,teaching, methodologies.
The significance of developing reading skills in translator and language teacher training
Authors: Kovacs Gabriella 
Published: January 2019

In certain domains, such as translatingand language teaching, appropriate reading comprehension and interpretation of written texts is essential; therefore, in the training process for these professions, the development of reading skills and reading strategy awareness should not be neglected. The purpose of this study is to examine the reading habits and strategies of a group of Hungarian first year translation and interpretation students, most of whom are also language teacher trainees when working with texts written in English. Their reading strategy awareness is measured with an instrument; their reading comprehension performance is assessed with the help of the reading comprehension part of a standardised test; correlation is measured between their reading comprehension level and their ability to translate an English text into their native language. The results show that studentsâ€™ reading comprehension skills are not always on the required level and their reading level significantly influences the ability to translate texts into Hungarian.

Keywords: Reading comprehension, reading strategies, reading for translation.
Metatraits of the successful university-level students
Authors: Eleonora Nosenko , Iryna Arshava , Victoria Kornienko , Kostiantyn Kutovyy , Inna Arshava 
Published: January 2019

As higher education acquisition is expected in all the civilised countries of the world not only to innovate the studentsâ€™ knowledge base but also to produce a humanising effect on their personalities, the aim of this study was to identify the key dispositional and dynamic metatraits of the successful university-level students potentially predictive of the humanising effect of education. Those metatraits were singled out with reference to the assumptions that they should denote how the individual thinks, feels and acts in the course of pursuing major life tasks suggested by the prominent personality psychology specialist J. B. Campbell. Using the quasi-experiment method, we have confirmed on a representative sample comprising big Ukrainian University students the existence of statistically significant differences in the above-mentioned metatraits of the more and less successful students. The findings allow to recommend accounting for the metatraits in the system of the personality selection and the assessment of the quality of education.

Keywords: Metatrait, metacognitive competence, emotional intelligence, self-efficacy beliefs, coping adequacy, positive values.
DIFRAKSI DAN EFEK SMILING PADA DATA SEISMIK
Authors: Gedo Sea Johannes , Massinai Muh. Altin , Aswad Sabrianto , Djajadihardja Yusuf Surachman 
Published: January 2019

AbstrakDifraksi dan efek smiling merupakan artefak yang sering terdapat pada data seismik. Difraksi timbul pada data sebelum dilakukan proses migrasi sedangkan efek smiling timbul setelah dilakukan proses migrasi. Dalam penelitian ini akan dibahas efek smiling pada penampang hasil migrasi yang pada wilayah tersebut merupakan tempat terjadinya difraksi sebelumnya. Kata Kunci: Difraksi, Efek Smiling, MigrasiAbstractDiffraction and smiling are the two effects that often present in a seismic data. Diffraction occurs before the migration process, while the smiling occurs after the migration process. This research will discuss the effect of smiling on a cross section of the result of migration, which is the diffraction happened in an area of investigationKeywords: Diffraction, Smiling Effect, Migration
IDENTIFIKASI POLA SEBARAN INTRUSI BATUAN BAWAH PERMUKAAN MENGGUNAKAN METODE GEOMAGNET DI SUNGAI JENELATA KABUPATEN GOWA
Authors: Nurdin Nur Hidayat , Massinai Muh. Altin , Aswad Sabrianto 
Published: January 2019

AbstrakPenelitian ini dilakukan di Sungai Jenelata, Kabupaten Gowa, Sulawesi Selatan mengunakan metode geomagnet . Tujuan dari penelitian ini yaitu mengidentifikasi struktur geologi bawah permukaan pada daerah penelitian. Jumlah titik pengukuran sebanyak 248 dengan area seluas 70 × 300 meter. Akuisisi data dilakukan dengan menggunakan satu alat magnetometer. Sementara pengolahan data menggunakan koreksi harian dan koreksi IGRF serta filter upward continuation. Pemodelan dilakukan dengan metode forward modeling dengan menggunakan perangkat lunak Mag2DC. Medan magnetik total berkisar antara 42.456 sampai 43.111,6 nT. Berdasarkan interpretasi kualitatif pada kontur anomali magnetik lokal didapatkan variasi nilai anomali antara -320 sampai 240 nT. Sedangkan interpretasi kuantitatif menunjukkan adanya batuan basalt dengan nilai suseptibilitas sampai SI, yang menerobos batuan pyroclastic dengan nilai suseptibilitas hingga SI dalam dalam bentuk dyke. Kata Kunci: Geomagnet, dyke, Suseptibilitas, Sungai Jenelata.AbstractThis research has been conducted using geomagnetic method at Jenelata River, Gowa regency, South Sulawesi. The purpose of this study is to identify subsurface geological structure of the study area. The number of measurement points as much as 248 points with area 70 × 300 meters. The process of data acquisition using a magnetometer. Data processing was carried out with the diurnal correction and IGRF correction and using filter upward continuation. Modelling conducted using forward modeling using the software Mag2DC. The total magnetic field ranges from 42,456 to 43,111.6 nT. Based on a qualitative interpretation obtain local magnetic anomaly contour variations values between -320 to 240 nT. While the quantitative interpretation indicates basalt rocks with susceptibility values to SI, which breached pyroclastic rocks with susceptibility values to SI, in the form of dyke. Keywords: Geomagnetic, dyke, Susceptibility, Jenelata River
PERUBAHAN PENGGUNAAN LAHAN DI KECAMATAN SIRIMAU KOTA AMBON
Authors: M. Laka Beatus , Sideng Uca , - Amal 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui luasan masing-masing perubahan penggunaan lahan Kecamatan Sirimau dilihat dari citra satelit tahun 2006-2016, mengetahui agihan perubahan penggunaan lahan Kecamatan Sirimau dilihat dari citra satelit tahun 2006-2016, dan untuk mengetahui Faktor-faktor apa saja yang mempengaruhi terjadinya perubahan penggunaan lahan di Kecamatan Sirimau. Penelitian dilaksanakan pada bulan Maret-April 2016 di Kecamatan Sirimau Kota Ambon. Penelitian ini adalah penelitian survey karena sebagian besar data secara langsung diolah dengan menggunakan metode pengamatan dan pengukuran lapangan. Subjek penelitian ini adalah perubahan penggunaan lahan di Kecamatan Sirimau Kota Ambon. Pengambilan data dalam penelitian ini adalah menggunakan sistem informasi geografi (SIG). Teknik analisis data yang digunakan adalah analisis menggunakan SIG dan deskriptif, data yang diperoleh dari hasil analisis SIG di sajikan dalam bentuk peta overlay yaitu peta penggunaan lahan tahun 2006-2016 Kecamatan Sirimau Kota Ambon. Peta ini kemudian ditumpang tindih, kemudian menghasilkan peta baru dan tabel perubahan penggunaan lahan kemudian dijelaskan secara deskriptif. Selanjutnya data yang diperoleh dianalisis kembali dengan menggunakan teknik analisis spasial keruangan untuk memaparkan perubahan penggunaan lahan yang terjadi di Kecamatan Sirimau dalam kurun waktu sepuluh tahun dengan menggunakan software arcgis versi 10.3. Setelah itu data yang berupa peta perubahan penggunaan lahan tahun 2006 dan 2016 dianalisis untuk mengetahui berapa besar agihan perubahannya. Berdasarkan hasil penelitian dapat ditarik kesimpulan bahwa perubahan luasan penggunaan lahan Kecamatan Sirimau Kota Ambon 10 tahun terakhir sangat besar untuk permukiman sebesar 1036,1 Ha dari tahun sebelumnya sebesar 966,9 Ha. Agihan perubahan penggunaan lahan Kecamatan Sirimau Kota Ambon 10 tahun terakhir mengarah ke selatan dan timur yaitu ke daerah pesisir pantai dan pegunungan, adapun perubahan penggunaan lahan kea rah timur di dominasi oleh perubahan dari lahan hutan dan lahan pertanian kering berubah ke lahan permukiman. Faktor-faktor yang mempengaruhi perubahan penggunaan lahan adalah tingginya tingkat laju pertumbuhan penduduk Kecamatan Sirimau yaitu sebesar 5,54% dengan kepadatan penduduk kurang lebih 1.925 orang/Km2.
IDENTIFIKASI KANDUNGAN UNSUR LOGAM BATUAN MENGGUNAKAN METODE XRF (X-RAY FLOURESCENCE) (STUDI KASUS: KABUPATEN BUTON)
Authors: . Jamaluddin , Umar Emi Prasetyawati 
Published: January 2019

Tujuan dari penelitian ini adalah untuk menentukan konsentrasi unsur logam besi (Fe), Mangan Mn), and nikel (Ni). Metode yang digunakan dalam penelitian ini yaitu dengan metode X-Ray (Fluoresence (XRF). Hasil penelitian menunjukkan bahwa konsentrasi rata-rata unsur logam besi (Fe) pada sampel Buton 1, Buton 2, Buton 3 dan Buton 4 berturut-turut adalah 48.17 %, 49.49 %, 56.64 % dan 41.63 %. Mangan (Mn) 1.78 %, 1.81 %, 0.985 % dan 1.69 %. Nikel (Ni) 3.34 % , 3.18 %, 9.22 % dan 3.88 % . Dari hasil karakterisasi X-Ray Fluorenscence (XRF) didapatkan besi (Fe) dominan terkandung dalam sampel dengan konsentrasi sekitar 41.63% sampai 56.64%. Bijih besi mengandung material magnetik berbasis besi (Fe) dalam bentuk mineral oksida besi yaitu Hematit (Fe2O3).