bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibular Collateral Ligament: Varus Stress Radiographic Analysis Using 3 Different Clinical Techniques
Authors: Kane Patrick W. , Cinque Mark E. , Moatshe Gilbert , Chahla Jorge , DePhillipo Nicholas N. , Provencher Matthew T. , LaPrade Robert F. 
Published: May 2018

Background: Fibular collateral ligament (FCL) tears are challenging to diagnose. Left untreated, FCL tears lead to residual ligament instability and increased joint loading on the medial compartment of the knee. Additionally, when a concomitant anterior cruciate ligament (ACL) reconstruction is performed, increased forces on reconstruction grafts occur, which may lead to premature graft failure. Stress radiographs constitute a reliable and validated technique for the objective assessment of a complete grade III FCL tear. Purpose: To evaluate side-to-side difference (SSD) values of lateral compartment gapping on varus stress radiographs in patients with a grade III injury to the FCL. Additionally, to evaluate the reliability and reproducibility of 3 different measurement techniques that used various radiographic reference points. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Inclusion criteria were patients who sustained an FCL with or without a concomitant ACL injury and underwent a combined FCL + ACL reconstruction between 2010 and 2016. Patients were excluded if they had a complete posterolateral corner injury, open physes, intra-articular fracture, meniscal root tear, other ligament injury, or prior surgery on either knee. All FCL tears were diagnosed with a clinical varus stress examination at 0° and 20° of knee flexion and varus stress radiographs at 20° of knee flexion measured in 3 different locations. The SSD for lateral compartment gapping was obtained from the varus stress radiographs and then statistically compared for interrater and intrarater reliability. Results: A total of 98 consecutive patients (50 males, 48 females; 13 isolated FCL injuries, 85 combined ACL + FCL injuries) with mean age 33.6 years (range, 18-69 years) were included. Measurement techniques 1, 2, and 3 had mean ± SD lateral compartment SSDs of 2.4 ± 0.20 mm, 2.2 ± 0.20 mm, and 2.0 ± 0.03 mm, respectively (no significant differences). Interrater reliabilities for the 3 measuring techniques were 0.83, 0.86, and 0.91, respectively, while intrarater reliabilities were 0.99, 0.77, and 0.99, respectively. Conclusion: This study demonstrated a lower SSD value of 2.2 mm to be consistent with a grade III FCL tear on clinician-applied varus stress radiographs in the clinical setting. Although all SSD measurement locations had excellent reliability, the method using the midpoint of the lateral tibial plateau was found to be the most reproducible.
Termination of SUNCT with intravenous lignocaine followed by oral mexiletine
Authors: Mulroy Eoin , Armstrong-Scott Oliver , Bergin Peter 
Published: May 2018

Background: The trigeminal autonomic cephalalgias (TACs) are a group of debilitating, pathophysiologically similar headache syndromes characterized by facial pain and autonomic symptoms in areas supplied by the trigeminal nerve. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is among the rarest of the TAC syndromes and can be particularly recalcitrant to treatment. Case: We describe the case of a 50-year old woman with difficult-to-control SUNCT whose pain was completely aborted within hours of commencing intravenous lignocaine therapy and was maintained pain-free after transitioning to oral mexiletine. Conclusion: This is the first report of successful transition from intravenous lignocaine to oral mexiletine in SUNCT, and we suggest that this treatment should be tried early in difficult-to-control SUNCT. This therapy is safe, effective and with minimal side effects if administered in an appropriate manner.
Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy
Authors: Humbert Olivier , Chan Frieda , Rajawat Yogendra S. , Torgerson Troy R. , Burtner Christopher R. , Hubbard Nicholas W. , Humphrys Daniel , Norgaard Zachary K. , O’Donnell Patricia , Adair Jennifer E. , Trobridge Grant D. , Scharenberg Andrew M. , Felsburg Peter J. , Rawlings David J. , Kiem Hans-Peter 
Published: May 2018

Key PointsIV delivery of FV vector using the phosphoglycerate kinase promoter outperforms EF1α-containing vector in the canine SCID-X1 model. G-CSF/AMD3100 mobilization before in vivo FV vector delivery improves kinetics and clonal diversity of lymphocyte reconstitution.
Efficacy and safety profile of xanthines in COPD: a network meta-analysis
Authors: Cazzola Mario , Calzetta Luigino , Barnes Peter J. , Criner Gerard J. , Martinez Fernando J. , Papi Alberto , Gabriella Matera Maria 
Published: May 2018

Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and displays a better safety profile than theophylline. Therefore, we performed a quantitative synthesis to compare the efficacy and safety profile of different xanthines in COPD.The primary end-point of this meta-analysis was the impact of xanthines on lung function. In addition, we assessed the risk of adverse events by normalising data on safety as a function of person-weeks. Data obtained from 998 COPD patients were selected from 14 studies and meta-analysed using a network approach.The combined surface under the cumulative ranking curve (SUCRA) analysis of efficacy (change from baseline in forced expiratory volume in 1 s) and safety (risk of adverse events) showed that doxofylline was superior to aminophylline (comparable efficacy and significantly better safety), bamiphylline (significantly better efficacy and comparable safety), and theophylline (comparable efficacy and significantly better safety).Considering the overall efficacy/safety profile of the investigated agents, the results of this quantitative synthesis suggest that doxofylline seems to be the best xanthine for the treatment of COPD.
State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances
Authors: Sambataro Gianluca , Sambataro Domenico , Torrisi Sebastiano Emanuele , Vancheri Ada , Pavone Mauro , Rosso Roberta , Schisano Matteo , Crimi Claudia , Pignataro Francesca , Fischer Aryeh , Del Papa Nicoletta , Vancheri Carlo 
Published: May 2018

The term interstitial pneumonia with autoimmune features (IPAF) has been proposed to define patients with interstitial lung disease (ILD) associated with autoimmune signs not classifiable for connective tissue diseases (CTDs). This new definition overcomes previous nomenclatures and provides a uniform structure for prospective studies through specific classification criteria.This work evaluates the characteristics of IPAF patients reported in the literature, to highlight potential limits through a comparative analysis and to suggest better performing classification criteria.Four retrospective studies on the IPAF population have been considered. The study subjects differed in age, sex, smoking habit, ILD pattern and outcomes. Another important difference lies in the diverse items considered in the classification criteria. The retrospective design of the studies and the absence from some of them of a rheumatologist clearly involved in the diagnosis may have influenced the data, but current IPAF criteria seem to include a rather heterogeneous population. To overcome these discrepancies, this review suggests a limitation in the use of single items and the exclusion of extremely specific CTD criteria. This should avoid the definition of IPAF for those diseases at different stages or at early onset. The investigation of a functional or morphological cut-off of pulmonary involvement would be useful.
Scientific analysis of tie luo, a Qing Dynasty calligraphy artifact in the Palace Museum, Beijing, China
Authors: Wei Le , Chen Wenjia , Jin Gaowa , Guo Zhimou , Wang Yunli , Kang Baoqiang , Wang Na , Gu An , Zhang Yun , Lei Yong 
Published: May 2018

Abstract

Tie luo (affixed hanging) was an expressive form of traditional Chinese calligraphy or paintings, and popular in the imperial palaces for interior decorations in Qing Dynasty (1644–1911 C.E.). A piece of calligraphic tie luo, written by an eminent calligrapher Gu Gao (1763–1832 C.E.), was restored recently in the Palace Museum, Beijing, China. The paper with pigment coating specially made for this calligraphic piece was named as fenjian. This article presented results from materials identification prior to the restoration. Multianalysis with scientific approaches revealed how tie luo was manufactured. It could be concluded that the investigated tie luo used a paper made from bast fibers of mulberry trees. And the decorative ground layer for the piece was also studied, which indicated that a type of organic red pigments were used for the masterpiece. White lead was considered as the main pigment, mixed with a red dye extracted from sappanwood. Meanwhile, animal glue, drying oils and beeswax were confirmed as the organic binding media. In dye analysis, protosappanin B and brazilin as well as brazilein were identified, which implied that sappanwood was used for the organic manufacture of pigments. In addition, both Nowik type A and C were found in the research, which were characteristic of sappanwood for identification.
All in the family: proneural bHLH genes and neuronal diversity
Authors: Baker Nicholas E. , Brown Nadean L. 
Published: May 2018

ABSTRACTProneural basic Helix-Loop-Helix (bHLH) proteins are required for neuronal determination and the differentiation of most neural precursor cells. These transcription factors are expressed in vastly divergent organisms, ranging from sponges to primates. Here, we review proneural bHLH gene evolution and function in the Drosophila and vertebrate nervous systems, arguing that the Drosophila gene atonal provides a useful platform for understanding proneural gene structure and regulation. We also discuss how functional equivalency experiments using distinct proneural genes can reveal how proneural gene duplication and divergence are interwoven with neuronal complexity.
System dynamic modelling of electricity planning and climate change in West Africa
Authors: Momodu Abiodun S. , Kivuti-Bitok Lucy 
Published: May 2018

Background: It is imperative to develop an efficient strategic approach to managing the push-pull factor in economic development, particularly as relates to climate change and energy interactions in the West African Region. This article demonstrates the use of System Dynamics Modelling (SDM) for that purpose; to manage the development of energy growth with reduced impact in regards to climate change. The complexities of energy planning in relation to climate change necessitates the need for the tool to examine low carbon economy mixed with traditional approaches of planning. Methods: Vensim DSS version 6.2 was used to develop the model. WAPP member country level data elicited from WAPP and ECOWAS Regional Electricity Regulatory Authority (ERERA) serves as the set of basic data used to develop and run the main model. These were complemented with other data elicited from various journal articles and internet sources. These include population and its average growth rate, GDP, per capita income, average per capita electricity demand, electricity generated, average electricity tariff, generation technology type, amongst others. Results: SDM demonstrates the capability to understand the theoretical frame for trade-offs between economic development and climate change, by handling the nonlinear relationship between generation adequacy and greenhouse gas (GHG) emission reduction for better targeted strategic regional intervention on climate change. Conclusion: The primary goal of this paper was to demonstrate the use of SDM to aid in resource planning in an inexpensive way to examine low carbon pathway. With the SDM, the goal of low carbon pathway in the energy system was achieved without the cost of controlled trials.
The Zambian Preterm Birth Prevention Study (ZAPPS): Cohort characteristics at enrollment
Authors: Castillo Marcela C. , Fuseini Nurain M. , Rittenhouse Katelyn , Price Joan T. , Freeman Bethany L. , Mwape Humphrey , Winston Jennifer , Sindano Ntazana , Baruch-Gravett Courtney , Chi Benjamin H. , Kasaro Margaret P. , Litch James A. , Stringer Jeffrey S. A. , Vwalika Bellington 
Published: May 2018

Background: Sub-Saharan Africa bears a disproportionate burden of preterm birth and other adverse outcomes. Not only is the background rate of preterm birth higher than in North America and Europe, but many facilities lack essential equipment and personnel resources to care for preterm neonates. A better understanding of the demographic, clinical, and biologic underpinnings of preterm birth is urgently needed to plan interventions and inform new discovery. Methods: The Zambian Preterm Birth Prevention Study (ZAPPS) is a prospective antenatal cohort established at the Women and Newborn Hospital of the University Teaching Hospital (UTH) in Lusaka, Zambia. We recruit pregnant women from the antenatal clinics of district health centers and the UTH for study participation. Women undergo ultrasound examination to determine eligibility by gestational age criteria. Enrolled participants receive routine antenatal and postnatal care, lab testing, midtrimester cervical length measurement, serial fetal growth monitoring and careful assessment of birth outcomes. Results: Between August 2015 and September 2017, we screened 1784 women, of whom 1450 (81.2%) met inclusion criteria and were enrolled. The median age at enrollment of study participants is 27 years (IQR 23–32). Participants are enrolled at a median gestational age of 16 weeks (IQR 13–18). Among all parous participants (N=866; 64%), 21% (N=182) reported a prior miscarriage, 49% (N=424) reported a prior preterm birth, and 13% (N=116) reported a prior stillbirth. The HIV seroprevalence in our cohort is 24%. Discussion: We have established a large antenatal cohort to characterize the epidemiological and biological determinants of adverse birth outcomes in Lusaka, Zambia. Findings from this cohort will help guide future studies, clinical care, and policy in the prevention and treatment of adverse birth outcomes.
Pancreatic cancer: A guide for practice nurses
Authors: Perry Margaret Ann 
Published: May 2018

Although rare, pancreatic cancer usually has a poor prognosis. Margaret Ann Perry explains the risk factors for, and diagnosis and treatment of, the disease Despite improved survival for those with many types of cancer, pancreatic cancer has continued to have poor outcomes. This article was written following the loss of a popular and well respected colleague who recently passed away from this devastating disease. It aims to alert practice nurses to the vague symptoms of pancreatic cancer, its diagnosis and management, and improve knowledge and understanding of this much-feared cancer type.
Treating eczema in children in general practice
Authors: Onselen Julie Van 
Published: May 2018

Atopic eczema is very common and the vast majority of children are treated in primary care. Julie Van Onselen highlights the key role practice nurses can play in helping to manage eczema Atopic eczema is very common in children and the vast majority are treated in primary care. Atopic eczema management mirrors management of chronic asthma in primary care. Practice nurses are well placed to be ‘atopic nurses’ and assess, educate and treat children with atopic eczema, in a framework of chronic disease management, as they do in asthma management. This article gives information on assessment, the stepped approach to atopic eczema management, and discusses adherence and education of parents/carers, children and families.
El castellano del Caribe colombiano en la ciudad de Nueva York: El uso variable de sujetos pronominales
Authors: Orozco Rafael 
Published: May 2018

ResumenEste estudio de la expresión de pronombres personales de sujeto entre hablantes del castellano caribeño colombiano en Nueva York revela una tasa pronominal (43 %) significativamente más alta que la existente en el Caribe colombiano. Los resultados descubren que cinco predictores lingüísticos y dos sociales condicionan la expresión pronominal. Los predictores lingüísticos – entre los cuales persona y número del sujeto condiciona más fuertemente el uso pronominal – revelan tendencias similares a las existentes alrededor del mundo hispánico. Los predictores sociales reflejan aumentos significativos en las tasas pronominales tanto de mujeres como de hombres en los diferentes grupos etarios analizados y también entre los recién llegados a Nueva York. Aunque existen similitudes superficiales con el resto del mundo en los efectos condicionantes internos, un análisis minucioso de los efectos del verbo descubre tendencias opuestas entre verbos agrupados en una misma categoría semántica; por ejemplo,irfavorece los sujetos expresos perosalirlos tácitos. Esto implica que clasificaciones basadas en criterios semánticos no constituirían la manera óptima de explorar los efectos del verbo en la expresión pronominal. Además, la tasa pronominal significativamente más alta entre los recién llegados tiene implicaciones metodológicas sugiriendo que estos hablantes no proporcionarían una muestra fidedigna de la expresión pronominal en sus comunidades de origen.
Activation of Self-Incompatibility Signaling in TransgenicArabidopsis thalianaIs Independent of AP2-Based Clathrin-Mediated Endocytosis
Authors: Yamamoto Masaya , Nishio Takeshi , Nasrallah June B 
Published: May 2018

AbstractInternalization of plasma membrane (PM)-localized ligand-activated receptor kinases and their trafficking to sorting endosomes have traditionally been viewed as functioning primarily in the down-regulation of receptor signaling, but are now considered to be also essential for signaling by some receptors. A major mechanism for internalization of PM proteins is clathrin-mediated endocytosis (CME). CME is mediated by the Adaptor Protein Complex 2 (AP2), which is involved in interaction of the AP2 μ-adaptin subunit with a tyrosine-based Yxxϕ motif located in the cytoplasmic domain of the cargo protein. In this study, we investigated the role of AP2-mediated CME for signaling by the S-locus receptor kinase (SRK), a protein localized in the PM of stigma epidermal cells, which, together with its pollen coat-localized S-locus cysteine-rich (SCR) ligand, functions in the self-incompatibility (SI) response of the Brassicaceae. Using Arabidopsis thaliana plants that were made self-incompatible by transformation with an A. lyrata-derived SRK/SCR gene pair, we tested the effect on SI of site-directed mutations in each of the two Yxxϕ motifs in SRK and of a CRISPR/Cas9-induced null mutation in the AP2 μ-adaptin gene AP2M. Both in vitro SRK kinase activity and the in planta SI response were abolished by substitution of tyrosine in one of the two Yxxϕ motifs, but were unaffected by elimination of either the second Yxxϕ motif or AP2M function. Thus, AP2-mediated CME is considered to be unnecessary for SRK signaling in the SI response.
Identificación de una colección de microalgas aisladas de Costa Rica mediante secuenciación de ADNr 18S
Authors: Gómez-Espinoza Olman , Guerrero-Barrantes Maritza , Meneses-Montero Karla , Núñez-Montero Kattia 
Published: May 2018

Las microalgas componen un diverso grupo polifilético de microorganismos fotosintéticos. Debido a su potencial biotecnológico, los estudios para aislar e identificar nuevas cepas han incrementado, por lo que es necesario el desarrollo de nuevas técnicas para su correcta identificación y clasificación. Utilizando herramientas de biología molecular, en este estudio se analizó el gen del ADNr 18S de 12 cepas microalgales aisladas de diferentes regiones de Costa Rica, resultando seis pertenecientes a la clase Trebouxiophyceae, tres a Chlorophyceae, dos a Prymnesiophyceae y una a Cyanidiophyceae. Este estudio reporta por primera vez la identificación molecular de cepas microalgales aisladas de Costa Rica, resaltando la diversidad de estos microorganismos en el país.
Mikroalgák mint természetes hatóanyagforrások
Authors: Vasas Gábor 
Published: May 2018

Abstract: More than 90% of herbal products and herbal medicines have been derived from higher plants recently, but due to independent circumstances, several photosynthetic microalgal species are in focus in this point of view. In the last 50 years, many carbohydrate-, peptide-, terpenoid-, alkaloid- and phenol-type components were described from algae because of the developing structural determination and analytical methods, algae mass production and also artificial algae technologies. At the same time, based partly on traditional causes and partly on the clinical and preclinical data of today, some dried products of algae are directly used as food supplements. Hereinafter, the historical background, economic significance and metabolic background of the mostly used microalgal species will be reviewed. The diverse metabolite production of these organisms will be demonstrated by some molecules with special bioactivity. Several preclinical and clinical studies will be described relating to the microalgal species Spirulina sp., Chlorella sp., Haematococcus sp. and Dunaliella sp. Orv Hetil. 2018; 159(18): 703–708.
Prevalence of overt and subclinical thyroid dysfunction among women and its effects on maternal and fetal outcome
Authors: Kumari Puja , Singh Sadhana 
Published: May 2018

Background: Objective of present study was to determine the current prevalence of thyroid dysfunction in normal pregnant women and to study the impact of thyroid dysfunction on maternal and fetal outcome.Methods: 400 pregnant women between 13 and 26 weeks of gestation were registered for the study. Apart from routine obstetrical investigations, TSH tests were done. Free T4 and anti-TPO antibody tests were done in patients with deranged TSH. Patients were followed up till delivery. Their obstetrical and perinatal outcomes were noted.Results: The prevalence of hypothyroidism and hyperthyroidism was and 1.25%, respectively. Adverse maternal effects in overt hypothyroidism included preeclampsia (16.6 vs. 7.8%) and placental abruption (16.6 vs. 0.8%). Subclinical hypothyroidism was associated with preeclampsia (22.3 vs. 7.8%) as compared to the euthyroid patients. Adverse fetal outcome in overt hypothyroidism included spontaneous abortion (16.6 vs. 2.39%), preterm birth (33.3 vs. 5.8%), low birth weight (50 vs. 12.11%), intrauterine growth retardation (25 vs. 4.9%), and fetal death (16.6 vs.7%) as compared to the euthyroid women. Adverse fetal outcomes in subclinical hypothyroidism included spontaneous abortion (5.5 vs. 2.39%), preterm delivery (11.2 vs. 5.8%), low birth weight (25 vs. 12.11%), and intrauterine growth retardation (8.4 vs. 4.9%) as compared to the euthyroid women.Conclusions: The prevalence of thyroid disorders was high in our study with associated adverse maternal and fetal outcomes. Routine screening of thyroid dysfunction is recommended to prevent adverse fetal and maternal outcome.