bluuebunny/crossref_metadata_2025_split huggingface dataset:
QUANTITATIVE VIBRATIONAL METHODS DEVELOPMENT AND ITS PERFORMANCE COMPARISON TO COLORIMETRY ON THE ASSAY OF KANAMYCIN SULFATE
Authors: NUGRAHANI ILMA , FAUZIA RIZKA 
Published: July 2019

Objective: The purpose of this study was to develop and validate Fourier Transform Infra-Red (FTIR) method for a non-chromophore antibiotic, kanamycin sulfate. Afterward, it was compared to other quantitative methods, namely colorimetry using ninhydrin.
Methods: FTIR was used to determine the level of kanamycin sulfate. Firstly, the absorbance spectra were measured. To increase the specificity, it used mathematical derivation, which would separate the active compound's spectrum clearer from the other component of the dosage form. The clearest absorbance spectra was found at 1540-1480 cm-1, as the N-H bending, which then was used as the base for the quantitative analysis. This method was then applied to determine the kanamycin sulfate content in the commercial reconstitution-injection dosage form. Afterward, the analysis performance compared to another method which had established, namely colorimetry. The counterpart method was using ninhydrin as the chemical reagent to produce a chromophore, which able to be measured by visible spectrophotometry. Validation test checked the parameters such as linearity, LOD, LOQ, range, accuracy, and precision, continuing to evaluate and to compare the time and material involved with the colorimetry as the counterpart.
Results: The results showed that FTIR for kanamycin sulfate lavel determination gave linearity within the range 0.12–1.5% w/w, with the r = 0.99975. Meanwhile, the LOD and LOQ were 0.04% and 0.12% w/w. There were no significant differences between the results of content determination of the antibiotic from the two methods. However, FTIR shows more advantages on time reducing, more straightforward preparation, solvents reducing, less costly, and more convenient.
Conclusion: FTIR is suitable to be an alternative method for quantifying kanamycin sulfate in a dosage form accurately, sensitive, and economist. This method is superior in its accuracy, precision, and simplicity compared to the colorimetry method using UV spectrometer as the counterpart.
FORMULATION DEVELOPMENT AND IN VITRO ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF ERIOBOTRYA JAPONICA BASED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM
Authors: SINGH AMRIT PAL , KHATIK GOPAL L. , MISHRA VIJAY , KHURANA NAVNEET , SHARMA NEHA , VYAS MANISH 
Published: July 2019

Objective: The aim of the present study was to develop and characterize self-nano emulsifying drug delivery system (SNEDDS) of methanolic extract of Eriobotrya japonica (Thunb.) Lindl. (E. japonica) leaves. Further in vitro antioxidant and antidiabetic potential of an optimized batch of SNEDDS was explored.
Methods: Oil (Labrafil M 1944 CS), surfactant (Tween 80) and co-surfactant (Transcutol P) were selected on the basis of solubility of the methanolic extract. Twenty-seven batches of SNEDDS were prepared with different compositions of oil, surfactant and co-surfactant. The optimized batch was evaluated for its entrapment efficiency, droplet size, polydispersity index (PDI), zeta potential, transmission electron microscopy (TEM). Further, DPPH assay and α-amylase activity were also performed to check the antioxidant and antidiabetic potential of prepared SNEDDS.
Results: The optimized design suggested that 10% of Labrafil M 1944CS, 30% of Tween 80 and 60% of Transcutol P could develop SNEDDS with 208 nm mean droplet size, 99.64% drug loading, 0.156 PDI and-6 mV zeta potential. TEM image confirmed the droplet size less than 100 nm and the spherical shape of SNEDDS. In vitro antioxidant and antidiabetic activities of SNEDDS revealed the increased efficacy as compared to that of the ascorbic acid and acarbose, respectively.
Conclusion: The optimized batch of SNEDDS was found to improve the antioxidant and antidiabetic efficacy of methanolic extract of E. japonica.
A COMPARISON STUDY OF HAIR TONIC AND GEL FORMULATION OF ANGIOPTERIS EVECTA AS A HAIR GROWTH STIMULANT
Authors: Mustarichie Resmi , Gozali Dolih - , Wicaksono Imam Adi , NAFIS FERIS DZAKY RIDWAN 
Published: July 2019

Objective: Previous research has proven that the water fraction of the Angiopteris evecta root has hair growth activities. The objective of this research was to determine the formula of gel and hair tonic preparations of pakis munding (Angiopteris evecta L.) which met the requirements as a pharmaceutical preparation, good and effective in stimulating hair growth.
Methods: Formulation of hair tonic and gel preparations were made using 7.5, 10.0, and 12.5 % of A. Evecta root water extracts as active compounds. The formulation of the two preparations was based on the standard formulation method. The evaluation and formulation test were carried out by organoleptic examination and homogeneity, pH, viscosity, scattering power test, stability test, and safety test based on the standard preparations including Indonesian pharmacopeia. Statistical tests were carried out on both formulas against rabbits based on the modification of the Tanaka method. Comparison of statistics on both formulas was also carried out.
Results: It was found both formulas fulfill standard requirements as pharmaceutical preparations. Statistically, the best activity in hair tonic preparations was at a concentration of 12.5% and for gels at a concentration of 10.0% ethanol extract seen from measurements of hair length. Statistically, using the Independent T-test to find out the significant differences in the average hair length on hair tonic and gel, it was found there was no significant difference between the two formulas. It was found that the best formula for hair tonic and gel was in the addition of 10.0% and 12.5% extracts, respectively.
Conclusion: The results obtained in this research work clearly indicated that both hair tonic and gel formulas of A. evecta root water extract may be used as stimulating hair growth.
FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF IBUPROFEN LOADED MICROEMULSION SYSTEM USING D-OPTIMAL MIXTURE DESIGN
Authors: ALAOUI YASSIR EL , FAHRY AICHA , RAHALI YOUNES , CHERKAOUI NAWAL , BENSOUDA YAHYA , LAATIRIS ABDELKADER 
Published: July 2019

Objective: The purpose of this study was to develop, optimize and characterize a stable microemulsion, with an improvement of the solubility of a poorly aqueous soluble drug, ibuprofen.
Methods: Various oils (oleic acid, cottonseed oil, olive oil, argan oil, and labrafac® WL 1349), surfactants (tween® 80, tween® 40, tween® 20) and co-surfactants including polyethylene glycol 400, ethanol, 1-butanol, and propylene glycol were selected after solubility studies. Then, pseudo-ternary phase diagrams with surfactant/co-surfactant ratio of 1:2, 1:1, 2:1 and 3:1 were constructed and a D-optimal mixture design method was used to optimize the ibuprofen loaded microemulsion. The optimized microemulsion was evaluated for several characteristics including globule size, zeta potential, pH, conductivity, refractive index and stability studies.
Results: Optimized microemulsion obtained was composed of oleic acid (6.88% w/w), tween® 80/1-butanol (3:1, 63.11% w/w) and water (30.00% w/w). The results obtained showed an average globule size of 117.5 nm, a zeta potential of-6.47 mV and a transmittance of 96.95±0.77%. The optimized formulation showed an improvement in the solubility of ibuprofen with unchanged characteristics for one month.
Conclusion: The use of pseudo-ternary phase diagrams and mathematical modeling allows to obtain an optimal microemulsion with perfect stability for 1 mo and a better solubilization capacity of ibuprofen.
METHOD VALIDATION OF RIFAMPICIN ANALYSIS IN HUMAN PLASMA AND ITS APPLICATION IN BIOEQUIVALENCE STUDY
Authors: LUKITANINGSIH ENDANG , JANNAH FATHUL , PEBRIANA RATNA BUDHI , PUSPITA RATNA DEWI , . TAUFIQUROHMAN , IKAWATI ZULLIES 
Published: July 2019

Objective: This research aims to validate the method for rifampicin analysis in plasma by using High-Performance Liquid Chromatography (HPLC) that can be used to study the bioequivalence of a generic tablet of rifampicin 450 mg “X” marketed in Indonesia.
Methods: Bioequivalence test was analysed using HPLC equipped with UV-Vis detector at 377 nm. The mobile phase used was acetonitrile-phosphate buffer pH 6.8 (45:55) delivered at a flow rate of 1.5 ml/min. Bioequivalence test was conducted on a limited number of subjects (n=8). The subjects were divided into two groups randomly. The pharmacokinetic profiles of the test tablet and reference tablet were statistically calculated using SPSS program to see the test tablet and reference tablet were bioequivalence or not.
Results: The developed HPLC method for rifampicin analysis in plasma was sufficiently valid based on the International Conference on Harmonization (ICH) and European Medicines Agency (EMA) guideline, with precision and accuracy values were % Relative Standard Deviation (% RSD = 1.40–13.04) and % Recovery (86.24–102.13), respectively. Meanwhile, the method was linear over studied concentration (0.05 to 10.26 µg/ml) with a coefficient of determination (R2) = 0.9984. The method also had good stability and sensitivity. The result of statistical calculation showed that the generic rifampicin tablet X was bioequivalence toward the reference tablet Rimactan 450 mg.
Conclusion: The test rifampicin tablet that was, the generic tablet “X” was bioequivalence toward the reference rifampicin tablet “Rimactan”.
PREPARATION AND CHARACTERIZATION OF CHITOSAN/REGENERATED SILK FIBROIN (CS/RSF) FILMS AS A BIOMATERIAL FOR CONTACT LENSES-BASED OPHTHALMIC DRUG DELIVERY SYSTEM
Authors: JEENCHAM RACHASIT , SUTHEERAWATTANANONDA MANOTE , Tiyaboonchai Waree 
Published: July 2019

Objective: The aim of this study was to develop chitosan/regenerated silk fibroin (CS/RSF) films as a biomaterial for contact lenses-based ophthalmic drug delivery system.
Methods: CS/RSF films were prepared with polyethylene glycol 400 as a plasticizer by using a film casting technique. Their physicochemical properties were investigated by measuring various properties such as thickness, morphology, chemical interaction, light transparency, mechanical properties, water content, oxygen permeability, thermal properties and enzyme degradation. In addition, cytotoxicity was also studied.
Results: At optimal preparation conditions, CS/RSF films showed smooth surfaces with highly visible light transparency of >90%, which meet the visual requirement. CS/RSF films showed high water content, 59-65% by weight, and their Young’s modulus and elongation at break was in the range of 3.8-6 N/mm2 and 113-135%, respectively. The CS/RSF films also could be sterilized by autoclave method as they possessed high thermal decomposition temperature of >260 °C which can be confirmed by both differential scanning calorimetry and thermogravimetric analysis. In addition, CS/RSF films showed no degradation in stimulated tear fluid containing lysozyme for 7 d and showed no cytotoxicity by MTT assay.
Conclusion: CS/RSF films showed excellent physicochemical properties and non-cytotoxicity indicating their promising potential use as a biomaterial for contact lenses-based ophthalmic drug delivery system.
DEVELOPMENT AND CHARACTERIZATION OF CREAM CONTAINING NANOSTRUCTURED LIPID CARRIERS FOR HAIR SPLIT-END REPAIRING
Authors: Prasertpol Tashatai , Tiyaboonchai Waree 
Published: July 2019

Objective: This study aimed to develop the nanostructured lipid carriers (NLCs) for repairing the hair split-end and to compare the influence of NLCs charges on hair binding effects.
Methods: NLCs was prepared by a high-pressure homogenization technique. The difference solid lipids were selected to obtain the negatively charged NLCs (N-NLCs) and positively charged NLCs (P-NLCs). The physical characterizations of both NLCs were examined. The NLCs cream was prepared by mixing NLCs into a cream base. Then, the hair split-end binding effects of the NLCs cream were assessed. The physical stability of both NLCs were investigated by kept at room temperature for 6 mo.
Results: The N-NLCs and P-NLCs were successfully prepared with a zeta potential of -44.4 mV and 32.3 mV, respectively. They were a spherical shape with a similar mean size of ~150-160 nm. The hair split-end evaluation showed that both NLCs illustrated similar hair split-end binding time of more than 3 d, suggesting no extra benefit from the positively charged of P-NLCs. On the contrary, the cream base and commercial product showed a short binding time of <8 h. Furthermore, after 6-mo storage, N-NLCs demonstrated good physical stability without particle aggregation, while P-NLCs exhibited a phase separation.
Conclusion: The developed NLCs is a novel alternative for the leave-on product, which would be highly benefits for hair split-end repairing.
PENGARUH PH DAN WAKTU PENYIMPANAN TERHADAP PERTUMBUHAN Lasiodiplodia theobromae PENYEBAB KANKER BATANG TANAMAN KARET
Authors: Febbiyanti Tri Rapani , Widodo Widodo , Wiyono Suryo , Yahya Sudirman 
Published: July 2019

Lasiodiplodia theobromae merupakan cendawan penyebab kanker batang pada tanaman karet (Hevea brasiliensis Muel Arg.), penyakit ini merupakan penyakit baru dan belum pernah dilaporkan sebelumnya di Indonesia. Banyak cara yang dapat dilakukan untuk mengendalikan penyakit kanker batang. Strategi pengendalian yang terbaik adalah dengan pengelolaan penyakit yang membutuhkan pengetahuan mengenai ekobiologi patogen, inang, dan interaksinya dengan lingkungan biotik dan abiotik. Pengendalian patogen harus didasarkan pada pengetahuan tentang bioekologinya. Diharapkan dengan pengetahuan bioekologi bisa dijadikan dasar untuk bisa menghambat perkembangan atau menurunkan populasi inokulum di lapangan. Penelitian ini bertujuan untuk menentukan pengaruh pH secara in vitro terhadap pertumbuhan patogen kanker batang dan laju penurunan viabilitas tubuh buah akibat penyimpanan. Kisaran pengaruh pH media meliputi 3, 4, 5, 6 dan 7. Penyimpanan tubuh buah dilakukan dalam wadah tanpa diberi tanah, diberi tanah steril dan tanah tidak steril. Penentuan viabilitas dilakukan pada 30, 60, 90 dan 120 hari masa penyimpanan. Semakin rendah pH menyebabkan pertumbuhan miselia terhambat.
INOVASI MEDIA PEMBELAJARAN BAHASA ARAB BERBASIS E-LEARNING
Authors: Silahuddin Silahuddin , Azhari Azhari 
Published: July 2019

The Arabic teaching-learning proccess at the Madrasah Aliyah in Aceh Besar has not been running optimally. Generally, the learning process is still conventional based. Therefore, a solute efforts is needed for a teacher to design and create learning medias based ICT. Namely: computer-based media, websites, online library, e Learning and android that can facilitate the spread of knowledge. This research are to investigate how the utilization of ICT can be used optimally in learning and how the ability of teachers in using ICT facilities as a learning media innovation. The research used is a research development with mixed method methodology, and the sample of the research is Madrasah Aliyah teachers in Aceh Besar District. The results showed: generally, the teachers have already known and understood the use of media in learning. Nevertheless, Teachers rarely most of them do not use e learning. The teachers have not done the innovation of learning media of ICT based. The researcher recommends. The Medias e learning can be used optimally in learning Arabic at Madrasah Aliyah Aceh Besar District.
Las Competencias Gerenciales en la Gestión de Instituciones de Educación Superior
Authors: Aristimuño V. Minerva , Guaita Wilfredo 
Published: July 2019

Esta investigación tiene como objetivo estudiar los componentes de las competencias gerenciales requeridas por directivos o gestores de las Instituciones de Educación Superior (IES). En este sentido, se determinan, de acuerdo a la percepción de los docentes que han desempeñado cargos de dirección en las IES estudiadas, cuálesdeberían ser las competencias de los cuadros directivos o gerenciales y como se interrelacionan estas competencias entre sí. Dado que el objeto de estudio son los docentes que tienen o han tenido cargos de autoridad en las IES estudiadas en susrespectivas organizaciones para-universitarias y/o gremiales, se determinó que la población total está constituida por 69 docentes, por lo cual no se calculó una muestra probabilística puesto que es un número pequeño de individuos. El instrumento diseñado fue sometido a la validación de expertos. Se calculó su confiabilidadobteniéndose un valor del alpha de Cronbach de 0,76, considerado como aceptable. El procesamiento de los datos permitió obtener las competencias gerenciales requeridas por los cuadros directivos, asi como las competencias de carácter personal y organizacional. Los resultados encontrados se convierten en insumos para el diseño deprogramas de formación, desarrollo y gestión de los directivos universitarios.
KINERJA PEREMPUAN WIRAUSAHA “GUREM” PENERIMA KREDIT
Authors: Safitri Laras Sirly , Suharno Suharno , Jahroh Siti 
Published: July 2019

ABSTRAK: Perempuan wirausaha merupakan salah satu faktor kunci pertumbuhan ekonomi, khususnya di perdesaan. Dalam pertumbuhan dan perkembangannya, usaha kecil bahkan skala “gurem” yang dijalankan perempuan seringkali menghadapi hambatan akses terhadap modal. Tujuan dari penelitian ini, untuk menganalisis dampak pemberian kredit melalui pengukuran kinerja usaha perempuan, sebelum dan setelah menerima kredit. Penelitian ini merupakan sebuah aksi yang berbasis pada riset eksperimen. Responden terdiri dari tiga puluh orang yang dipilih secara sengaja (purposive) untuk diberikan perlakuan berupa kredit modal usaha. Hasil analisis menunjukkan bahwa kinerja usaha perempuan penerima kredit belum meningkat setelah menerima kredit. Hal tersebut ditunjukkan oleh tingkat pengembalian kredit yang hanya mencapai 83 persen. Di samping itu, Uji Pangkat Tanda Wilcoxon menunjukkan bahwa tidak terdapat perbedaan omset rata-rata per hari dan marjin keuntungan rata-rata per hari perempuan wirausaha, baik sebelum maupun setelah menerima kredit. Perlu penelitian lanjutan yang dapat mendesain ulang penyaluran kredit yang sesuai dengan kondisi dan kebutuhan perempuan wirausaha, serta dilengkapi dengan pendampingan manajemen usaha. Kata kunci: perempuan wirausaha “gurem”, kredit, tingkat pengembalian, omset, marjin keuntungan
Solving Sat in a Distributed Cloud: A Portfolio Approach
Authors: Ngoko Yanik , Cérin Christophe , Trystram Denis 
Published: July 2019

Abstract
We introduce a new parallel and distributed algorithm for the solution of the satisfiability problem. It is based on an algorithm portfolio and is intended to be used for servicing requests in a distributed cloud. The core of our contribution is the modeling of the optimal resource sharing schedule in parallel executions and the proposition of heuristics for its approximation. For this purpose, we reformulate a computational problem introduced in a prior work. The main assumption is that it is possible to learn optimal resource sharing from traces collected on past executions on a representative set of instances. We show that the learning can be formalized as a set coverage problem. Then we propose to solve it by approximation and dynamic programming algorithms based on classical greedy algorithms for the maximum coverage problem. Finally, we conduct an experimental evaluation for comparing the performance of the various algorithms proposed. The results show that some algorithms become more competitive if we intend to determine the trade-off between their quality and the runtime required for their computation.
Lyapunov–based Anomaly Detection in Preferential Attachment Networks
Authors: Ruiz Diego , Finke Jorge 
Published: July 2019

Abstract
Network models aim to explain patterns of empirical relationships based on mechanisms that operate under various principles for establishing and removing links. The principle of preferential attachment forms a basis for the well-known Barabási–Albert model, which describes a stochastic preferential attachment process where newly added nodes tend to connect to the more highly connected ones. Previous work has shown that a wide class of such models are able to recreate power law degree distributions. This paper characterizes the cumulative degree distribution of the Barabási–Albert model as an invariant set and shows that this set is not only a global attractor, but it is also stable in the sense of Lyapunov. Stability in this context means that, for all initial configurations, the cumulative degree distributions of subsequent networks remain, for all time, close to the limit distribution. We use the stability properties of the distribution to design a semi-supervised technique for the problem of anomalous event detection on networks.
Times Series Averaging and Denoising from a Probabilistic Perspective on Time–Elastic Kernels
Authors: Marteau Pierre-Francois 
Published: July 2019

Abstract
In the light of regularized dynamic time warping kernels, this paper re-considers the concept of a time elastic centroid for a set of time series. We derive a new algorithm based on a probabilistic interpretation of kernel alignment matrices. This algorithm expresses the averaging process in terms of stochastic alignment automata. It uses an iterative agglomerative heuristic method for averaging the aligned samples, while also averaging the times of their occurrence. By comparing classification accuracies for 45 heterogeneous time series data sets obtained by first nearest centroid/medoid classifiers, we show that (i) centroid-based approaches significantly outperform medoid-based ones, (ii) for the data sets considered, our algorithm, which combines averaging in the sample space and along the time axes, emerges as the most significantly robust model for time-elastic averaging with a promising noise reduction capability. We also demonstrate its benefit in an isolated gesture recognition experiment and its ability to significantly reduce the size of training instance sets. Finally, we highlight its denoising capability using demonstrative synthetic data. Specifically, we show that it is possible to retrieve, from few noisy instances, a signal whose components are scattered in a wide spectral band.