bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potenziale des Dritten Sozialmedizinischen Panels für Erwerbspersonen (SPE-III) für die Forschung im Bereich Migration und Rehabilitation: Das Beispiel der Inanspruchnahme rehabilitativer Versorgung
Authors: Brzoska Patrick , Spanier Katja , Bethge Matthias 
Published: February 2019

Zusammenfassung
Ziel der Studie Die Mehrzahl bisheriger Studien zeigt, dass Menschen mit Migrationshintergrund die medizinische Rehabilitation seltener als Menschen ohne Migrationshintergrund nutzen. Teilweise werden jedoch auch gegensätzliche Ergebnisse berichtet. Bisherige Untersuchungen haben unterschiedliche Limitationen. Die vorliegende Studie untersucht die Inanspruchnahme von Rehabilitation bei Menschen mit und ohne Migrationshintergrund auf Basis des Dritten Sozialmedizinischen Panels für Erwerbspersonen (SPE-III).
Methodik Die Auswertung basiert auf der ersten Erhebungswelle des SPE-III, erweitert um administrative Daten aus den Versicherungskonten der jeweiligen Studienteilnehmerinnen und -teilnehmer. Die Befragung wurde im Mai 2013 durchgeführt und umfasst eine Risikokohorte von in ihrer Teilhabe gefährdeten Versicherten der Deutschen Rentenversicherung Bund mit Krankengeldbezug im Jahr 2012. Es wird zwischen ausländischen Staatsangehörigen, deutschen Staatsangehörigen mit und deutschen Staatsangehörigen ohne Migrationshintergrund unterschieden. Als Kovariaten wurden in Anlehnung an das Andersen Healthcare Utilization Model die Lebensqualität, die subjektive Gefährdung der Erwerbsfähigkeit sowie demografische und sozioökonomische Faktoren über ein logistisches Regressionsmodell berücksichtigt.
Ergebnisse Von den 2413 eingeschlossenen Befragten waren 2,7% ausländische Staatsangehörige und 4,4% deutsche Staatsangehörige mit Migrationshintergrund. Die Inanspruchnahme von Rehabilitation unterschied sich bei Deutschen mit Migrationshintergrund und ausländischen Staatsangehörigen nicht signifikant von der Inanspruchnahme bei Deutschen ohne Migrationshintergrund (adjustiertes Odds Ratio=0,78; 95%-CI=0,47–1,30 bzw. adjustiertes Odds Ratio=0,99; 95%-CI=0,53–1,88).
Schlussfolgerungen Durch die detaillierte Erfassung des Migrationshintergrundes, die Möglichkeit, Einflussfaktoren auf unterschiedlichen Ebenen zu berücksichtigen sowie die Verknüpfbarkeit von Befragungsdaten mit Routinedaten erlaubt es das SPE-III, einige Limitation früherer Studien zu überwinden. Die Ergebnisse stehen im Widerspruch zur Mehrheit dieser Studien und machen damit deutlich, dass die versorgungsepidemiologische Studienlage zur Inanspruchnahme rehabilitativer Versorgung bei Menschen mit Migrationshintergrund insgesamt inkonsistent ist. Bei der Interpretation der vorliegenden Ergebnisse müssen auch der besondere Zuschnitt des SPE-III sowie die vergleichsweise geringe Fallzahl berücksichtigt werden.
POLAR Diversion: Using General Practice Data to Calculate Risk of Emergency Department Presentation at the Time of Consultation
Authors: Pearce Christopher , McLeod Adam , Rinehart Natalie , Patrick Jon , Fragkoudi Anna , Ferrigi Jason , Deveny Elizabeth , Whyte Robin , Shearer Marianne 
Published: February 2019

Objective This project examined and produced a general practice (GP) based decision support tool (DST), namely POLAR Diversion, to predict a patient's risk of emergency department (ED) presentation. The tool was built using both GP/family practice and ED data, but is designed to operate on GP data alone.
Methods GP data from 50 practices during a defined time frame were linked with three local EDs. Linked data and data mapping were used to develop a machine learning DST to determine a range of variables that, in combination, led to predictive patient ED presentation risk scores. Thirteen percent of the GP data was kept as a control group and used to validate the tool.
Results The algorithm performed best in predicting the risk of attending ED within the 30-day time category, and also in the no ED attendance tests, suggesting few false positives. At 0 to 30 days the positive predictive value (PPV) was 74%, with a sensitivity/recall of 68%. Non-ED attendance had a PPV of 82% and sensitivity/recall of 96%.
Conclusion Findings indicate that the POLAR Diversion algorithm performed better than previously developed tools, particularly in the 0 to 30 day time category. Its utility increases because of it being based on the data within the GP system alone, with the ability to create real-time “in consultation” warnings. The tool will be deployed across GPs in Australia, allowing us to assess the clinical utility, and data quality needs in further iterations.
Predictors of Mental Health and Substance use Disorder Treatment use over 3 Years among Rural Adults using Stimulants
Authors: Cucciare Michael A. , Ounpraseuth Songthip T. , Curran Geoffrey M. , Booth Brenda M. 
Published: February 2019

Background Persons using substances, living in rural communities, tend to underutilize mental health (MH) and substance use disorder (SUD) treatment compared with their urban peers. However, no studies have examined longitudinal predictors of MH and SUD treatment use among rural persons using stimulants. Methods Data were collected through interviews conducted between 2002 and 2008 from a natural history study of 710 adults using stimulants and living in rural counties of Arkansas, Kentucky, and Ohio. Each study site recruited participants using respondent-driven sampling (RDS). Participants were adults, not in drug treatment, and reporting past-30-day use of methamphetamine, crack cocaine, or powder cocaine. Study participants completed face-to-face baseline assessments and follow-up interviews using computer-assisted personal interviews. Follow-up interviews were conducted at 6-month intervals for 3 years. Results Our results show that being male, nonwhite, and having a prior lifetime history of MH or SUD treatment use were associated with lower odds of using MH and SUD treatment over time; having medical insurance and living in a state with potentially greater availability of MH and SUD treatment were associated with higher odds of using MH and SUD treatment over the 3-year period. Further, reporting greater legal problems and alcohol severity were associated with greater odds of using MH and SUD care, whereas greater employment problems was associated with higher odds of SUD but not MH treatment use. Conclusions Findings from this study could be used to inform clinical and public health strategies for improving linkage to MH and SUD care in this population. Our findings also highlight the importance of having medical insurance as a potential facilitator to utilizing SUD care in this population and support the need for health care policies that increase the ability of rural adults who use stimulants to pay for such services.
Goal Commitment Predicts Cannabis use for Adolescents in Treatment
Authors: Kaminer Yifrah , Ohannessian Christine M. , Burke Rebecca H. 
Published: February 2019

Background Commitment to change is an innovative potential mediator and mechanism of behavior change (MOBC) that has not been examined in adolescents with cannabis use. The Adolescent Substance Abuse Goal Commitment (ASAGC) questionnaire is a reliable and valid 2-scale measure developed to assess the adolescent's commitment to either abstinence or harm reduction model for adolescents, which in addition to decrease in negative consequences includes consumption reduction as a stated treatment goal. The objective of this paper is to examine the ASAGC's ability to predict adolescent substance use treatment outcome. Methods During Sessions 3 and 9 of a 10-week treatment program, therapists completed the ASAGC for 170 adolescents 13–18 years of age with alcohol use disorders, the majority of whom (82%) were diagnosed with co-occurring cannabis use disorder (CUD). Results Logistic regression analyses assessing goal commitment regarding cannabis use at Session 3 indicated that commitment to both abstinence and harm reduction predicted cannabis use at Session 3. However, only commitment to abstinence predicted later cannabis use (assessed at Session 9 and during aftercare). When goal commitment at Session 9 was examined, only commitment to abstinence predicted cannabis use, concurrently and longitudinally. These results indicated that adolescents who had higher scores for commitment to abstinence were less likely to be positive for cannabis use. In contrast, harm reduction was not a significant predictor of cannabis use. Conclusions Findings demonstrate that goal commitment consistently predicts cannabis use treatment outcome. Commitment to abstinence specifically is a salient predictor for concurrent and future cannabis use. Further prospective study is necessary to determine whether harm reduction may be an attainable goal for some youth given normative delayed neurodevelopmental processes of inhibitive behaviors.
Routine Solid Phase Multiplex Anti-HLA Antibody Tests Predict Platelet Refractoriness
Authors: Peña Jeremy Ryan A , Makar Robert S 
Published: February 2019

ABSTRACTObjectivesNo validated screening methods identify patients at risk for human leukocyte antigen (HLA) alloimmune-mediated platelet refractoriness (alloPR). We determined if bead-based HLA antibody tests could predict risk of developing HLA alloPR.MethodsHematopoietic progenitor cell transplant patients screened for HLA antibodies without prior refractoriness were identified. Phenotype bead screening results were compared between patients who later did and did not develop alloPR.ResultsSeven of 27 patients identified subsequently developed alloPR. The panel reactive antibody (PRA) and mean fluorescence intensity (MFI) of the 10 most reactive beads in the initial screen were significantly higher among patients who later developed alloPR (P < .001). Specifically, PRA of more than 30% and mean MFI of 1,500 or more in the most reactive beads identified at-risk patients. Administration of HLA-compatible platelets yielded significant posttransfusion count increments compared with routine platelets.ConclusionsHLA antibody screening by phenotype bead assay may prospectively identify at-risk patients for the development of alloPR. However, clinical trials are needed to validate these findings.
Robbers, pickpockets and average mutual firmness
Authors: Koscholke Jakob 
Published: February 2019

Abstract
Mark Siebel (2004) has presented a compelling argument against Branden Fitelson’s (2003) probabilistic measure of coherence. The present paper shows how Siebel’s argument can be strengthened and thereby extended to an argument against a huge class of coherence measures from the literature including William Roche’s (2013) average mutual firmness account, which has not been challenged up to now.
Genetic relatedness delineates the social structure of southern Australian bottlenose dolphins
Authors: Diaz-Aguirre Fernando , Parra Guido J , Passadore Cecilia , Möller Luciana 
Published: February 2019

AbstractSocial relationships represent an adaptive behavioral strategy that can provide fitness benefits to individuals. Within mammalian societies, delphinids are known to form diverse grouping patterns and show a variety of social systems. However, how ecological and intrinsic factors have shaped the evolution of such diverse societies is still not well understood. In this study, we used photo-identification data and biopsy samples collected between March 2013 and October 2015 in Coffin Bay, a heterogeneous environment in South Australia, to investigate the social structure of southern Australian bottlenose dolphins (Tursiops cf. australis). Based on the data from 657 groups of dolphins, we used generalized affiliation indices, and applied social network and modularity methods to study affiliation patterns among individuals and investigate the potential presence of social communities within the population. In addition, we investigated genetic relatedness and kinship relationships within and between the communities identified. Modularity analysis revealed that the Coffin Bay population is structured into 2 similar sized, mixed-sex communities which differed in ranging patterns, affiliation levels and network metrics. Lagged association rates also indicated that nonrandom affiliations persisted over the study period. The genetic analyses suggested that there was higher relatedness, and a higher proportion of inferred full-sibs and half-sibs, within than between communities. We propose that differences in environmental conditions between the bays and kinship relationships are important factors contributing to the delineation and maintenance of this social structure.
DECO: decompose heterogeneous population cohorts for patient stratification and discovery of sample biomarkers using omic data profiling
Authors: Campos-Laborie F J , Risueño A , Ortiz-Estévez M , Rosón-Burgo B , Droste C , Fontanillo C , Loos R , Sánchez-Santos J M , Trotter M W , De Las Rivas J 
Published: February 2019

AbstractMotivationPatient and sample diversity is one of the main challenges when dealing with clinical cohorts in biomedical genomics studies. During last decade, several methods have been developed to identify biomarkers assigned to specific individuals or subtypes of samples. However, current methods still fail to discover markers in complex scenarios where heterogeneity or hidden phenotypical factors are present. Here, we propose a method to analyze and understand heterogeneous data avoiding classical normalization approaches of reducing or removing variation.ResultsDEcomposing heterogeneous Cohorts using Omic data profiling (DECO) is a method to find significant association among biological features (biomarkers) and samples (individuals) analyzing large-scale omic data. The method identifies and categorizes biomarkers of specific phenotypic conditions based on a recurrent differential analysis integrated with a non-symmetrical correspondence analysis. DECO integrates both omic data dispersion and predictor–response relationship from non-symmetrical correspondence analysis in a unique statistic (called h-statistic), allowing the identification of closely related sample categories within complex cohorts. The performance is demonstrated using simulated data and five experimental transcriptomic datasets, and comparing to seven other methods. We show DECO greatly enhances the discovery and subtle identification of biomarkers, making it especially suited for deep and accurate patient stratification.Availability and implementationDECO is freely available as an R package (including a practical vignette) at Bioconductor repository (http://bioconductor.org/packages/deco/).Supplementary informationSupplementary data are available at Bioinformatics online.
Time-lapse imaging: the state of the art†
Authors: Gallego Raquel Del , Remohí José , Meseguer Marcos 
Published: February 2019

Abstract
The introduction of time-lapse imaging to clinical in vitro fertilization practice enabled the undisturbed monitoring of embryos throughout the entire culture period. Initially, the main objective was to achieve a better embryo development. However, this technology also provided an insight into the novel concept of morphokinetics, parameters regarding embryo cell dynamics. The vast amount of data obtained defined the optimal ranges in the cell-cycle lengths at different stages of embryo development. This added valuable information to embryo assessment prior to transfer. Kinetic markers became part of embryo evaluation strategies with the potential to increase the chances of clinical success. However, none of them has been established as an international standard. The present work aims at describing new approaches into time-lapse: progress to date, challenges, and possible future directions.
Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter
Authors: Kanellakis Nikolaos I , Giannou Anastasios D , Pepe Mario A A , Agalioti Theodora , Zazara Dimitra E , Giopanou Ioanna , Psallidas Ioannis , Spella Magda , Marazioti Antonia , Arendt Kristina A M , Lamort Anne Sophie , Champeris Tsaniras Spyridon , Taraviras Stavros , Papadaki Helen , Lilis Ioannis , Stathopoulos Georgios T 
Published: February 2019

Abstract
Lung adenocarcinoma (LADC) is the leading cause of cancer death worldwide. Nevertheless, syngeneic mouse models of the disease are sparse, and cell lines suitable for transplantable and immunocompetent mouse models of LADC remain unmet needs. We established multiple mouse LADC cell lines by repeatedly exposing two mouse strains (FVB, Balb/c) to the tobacco carcinogens urethane or diethylnitrosamine and by culturing out the resulting lung tumours for prolonged periods of time. Characterization of the resulting cell lines (n = 7) showed that they were immortal and phenotypically stable in vitro, and oncogenic, metastatic and lethal in vivo. The primary tumours that gave rise to the cell lines, as well as secondary tumours generated by transplantation of the cell lines, displayed typical LADC features, such as glandular architecture and mucin and thyroid transcription factor 1 expression. Moreover, these cells exhibited marked molecular similarity with human smokers’ LADC, including carcinogen-specific Kras point mutations (KrasQ61R in urethane- and KrasQ61H in diethylnitrosamine-triggered cell lines) and Trp53 deletions and displayed stemness features. Interestingly, all cell lines overexpressed proliferin, a murine prolactin orthologue, which functioned as a lung tumour promoter. Furthermore, prolactin was overexpressed and portended poor prognosis in human LADC. In conclusion, we report the first LADC cell lines derived from mice exposed to tobacco carcinogens. These cells closely resemble human LADC and provide a valuable tool for the functional investigation of the pathobiology of the disease.
Economic overview of a two-agent process for underground coal gasification with Fischer–Tropsch-based poly-generation
Authors: Brand Johan F , Van Dyk Johan C , Waanders Frans B 
Published: February 2019

Abstract
Underground Coal Gasification (UCG) is a mining-gasification process that produces synthesis gas from in situ coal by injecting air (or oxygen and steam) and extracting the produced gas via boreholes. The resulting synthesis gas (‘syngas’) produced by UCG can be used directly as a fuel-gas or deep-cleaned to produce many other products like chemicals, liquid fuels, hydrogen and synthetic natural gas. UCG has significant environmental, safety and practical advantages over conventional coal mining and utilization, foremost being cost and emissions reductions. In South Africa, facilities of an industrial-scale Fischer–Tropsch (FT) have been operating for decades on coal-to-liquid and gas-to-liquid conversion. Oxygen-blown UCG produces syngas, which contains a mixture of carbon monoxide (CO) and hydrogen, and these molecules can be conditioned to serve as feed for synthetic-crude-oil (‘syncrude’) conversion technologies based on the FT process. African Carbon Energy (Pty) Ltd. (Africary) completed a study integrating its UCG technology with mini gas-to-liquids plant. Syngas from Africary’s Theunissen Underground Coal Gasification (TUCG) project will be used for power production and synthesis of liquid fuels in a unique poly-generation configuration. The TUCG process will consist of two parallel gasifiers, operated on different agents, making the component parts of UCG and coal-to-(any product) (CtX) tightly linked and interdependent, but reducing both cost and emissions. UCG-CtX offers a lower capital investment to conventional underground mining and surface gasification due to the removal of the surface gasifier and coal-mine operations. The gas clean-up systems will remove undesirable components from each gasifier and blend the cleaned syngas for H2:CO ratio control and provide implementation of carbon capture and sequestration. This study has minimized the complexity and optimized the process flow to provide own-use electricity and about 4000 barrels/day equivalent fuels at a capital cost estimate (2017) of about US$ 350 million and operating cost of around 28 US$/barrel.
KCC2 Manipulation Alters Features of Migrating Interneurons in Ferret Neocortex
Authors: Djankpa F T , Lischka F , Chatterjee M , Juliano S L 
Published: February 2019

Abstract
KCC2 is a brain specific chloride–potassium cotransporter affecting neuronal development including migration and cellular maturation. It modulates chloride homeostasis influencing the switch of GABA from depolarizing to hyperpolarizing, which contributes to the cues that influence the termination of neuronal migration. The expression of KCC2 during migration of interneurons, therefore, correlates with the ability of these cells to respond to GABA as a stop signal. Manipulation of KCC2 in development can affect various aspects of migrating neurons, including the speed. We describe the effect of KCC2 downregulation and inhibition on features of migrating interneurons of normal ferret kits and those treated with methylazoxymethanol acetate, which increases KCC2. Treatment of organotypic cultures with Bisphenol A, an environmental toxin that alters gene expression, also downregulates KCC2 protein. In organotypic slices treated with the KCC2 antagonist VU0240551, chloride imaging shows inhibition of KCC2 via blockade of chloride flux. Time-lapse video imaging of organotypic cultures treated with either drug, shows a significant increase in the average speed, step size, and number of turns made by migrating neurons leaving the ganglionic eminence. Our findings demonstrate the harmful effect of environmental toxins on brain development and potential consequences in the pathogenesis of neurodevelopmental disorders.
Children Use Regions in the Visual Processing and Executive Function Networks during a Subsequent Memory Reading Task
Authors: Farah Rola , Coalson Rebecca S , Petersen Steven E , Schlaggar Bradley L , Horowitz-Kraus Tzipi 
Published: February 2019

Abstract
Memory encoding is a critical process for memory function, which is foundational for cognitive functioning including reading, and has been extensively studied using subsequent memory tasks. Research in adults using such tasks indicates the participation of visual and cognitive-control systems in remembered versus forgotten words. However, given the known developmental trajectories of these systems, the functional neuroanatomy of memory encoding in children may be different than in adults. We examined brain activation for silent word reading and checkerboard viewing during an event-related reading task in 8–12 year-old children. Results indicate greater activation for checkerboard viewing than lexical processing in early visual regions, as well as for lexical processing versus checkerboard viewing in regions in left sensorimotor mouth, cingulo-opercular and dorsal-attention networks. Greater activation for remembered than forgotten words was observed in bilateral visual system and left lateralized regions within the ventral- and dorsal-attention, cingulo-opercular and fronto-parietal networks. These findings suggest a relatively mature reliance on the cognitive-control system, but greater reliance on the visual system in children when viewing words subsequently remembered. The location of regions with greater activity for remembered words reinforces the involvement of the attention and cognitive-control systems in subsequent memory in reading.