bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network-Pharmacology and DFT Based Approach Towards Identification of Leads from Homalomena aromatica for Multi-Target In-Silico Screening on Entamoeba histolytica Proteins
Authors: Goswami Ashis Kumar , Sharma Hemanta Kumar , Gogoi Neelutpal , Gogoi Bhaskar Jyoti 
Published: August 2019

Background:
Entamoeba histolytica is the primary protozoan that causes amoebic dysentery
and is prioritized as the third most prevalent protozoan causing parasitosis. Drug of choice in
amoebic dysentery is metronidazole but it has unpleasant side effects with reports of development
of resistance in certain cases. Homalomena aromatica Schott. is a plant which is used in different
ethnomedicinal practices of South-east Asia to treat stomach ailments against intestinal parasites.

Objective:
the present study, a docking weighted network pharmacology-based approach was
employed to understand the effects of a library of 71 natural molecules reported from Homalomena
aromatica with reference to four proteins of Entamoeba histolytica namely thioredoxin reductase,
cysteine synthase, glyceraldehyde-3-phosphate dehydrogenase, and ornithine decarboxylase.

Method:
Molecular docking of the phytoconstituents of H. aromatica was performed in Biovia
Discovery Studio 2017 R2 software suite on the selected proteins of E. histolytica. A connection
was established between the proteins and molecules through network pharmacology weighted docking
studies with the help of Cytoscape V3.4.0 software to select three molecules namely HM 7, HM
23 and HM 24 on the basis of the generated network between the molecules and targets. Quantum
mechanics based Density Functional Theory (DFT) analysis was performed on the filtered molecules
to ascertain their viability with respect to LUMO-HOMO orbital energies of the filtered molecules.

Results:
On the basis of the docking studies of the natural molecules on the selected protein targets,
a network of molecules was built. DFT based minimum energy gap was analysed to further ascertain
the most potential inhbitors. Three molecules from H. aromatica; 3,7-dimethylocta-1,6-dien-3-
yl acetate, α -methyl-α-(4-methyl-3-pentenyl)-oriranemethanol, and 7-octadiene-2,6-diol-2,6-
dimethyl were predicted to be potential lead molecules against amoebiasis.

Conclusion:
The present study provides important evidence for the development of new drug molecules
to treat amoebiasis.
A Rare Case of Drug-Induced Erectile Dysfunction with Secukinumab Solved After Switch to Ixekizumab in A Psoriatic Patient: A Case Report
Authors: Dastoli Stefano , Iannone Luigi Francesco , Bennardo Luigi , Silvestri Martina , Palleria Caterina , Nisticò Steven Paul , De Sarro Giovambattista , Russo Emilio 
Published: August 2019

Background:
Psoriasis is a cutaneous inflammatory condition characterized by an altered
turnover of keratinocytes leading to scaly patches. Secukinumab and ixekizumab are two biologic
drugs inhibiting interleukin-17.

Objective:
We report the first case, according to Naranjo score, of a secukinumab-induced erectile
dysfunction with severe plaque psoriasis that disappeared after switching to another anti IL17 drug
(ixekizumab).

Methods:
A 45 years old man experienced erectile dysfunction during treatment with an anti-IL17.
The adverse effect appeared after 60 days of treatment with secukinumab and rapidly disappeared after
discontinuation of the drug. All necessary urologic exams were carried out. Re-administration of
secukinumab, due to the exacerbation of psoriasis, caused the same sexual dysfunction after 60 days.

Results:
Switching to ixekizumab lead to a resolution of the erectile dysfunction and a complete
skin clearance.

Conclusion:
We describe for the first time a sexual dysfunction possibly due to secukinumab and
its resolution after the switch to another similar but different drug, highlighting the potential difference
between anti-IL17A drugs.
New Derivatives of Bacteriopurpurin with Thiolated Au (I) Complexes: Dual Darkand Light Activated Antitumor Potency
Authors: Grin Mikhail A. , Tikhonov Sergei I. , Petrova Albina S. , Pogorilyy Victor A. , Noev Аlexey N. , Tatarskiy Victor V. , Shpakovsky Dmitry B. , Milaeva Elena R. , Kalinina Elena V. , Chernov Nikolai N. , Shtil Аlexander А. , Mironov Andrey F. , Kaprin Andrey D. , Filonenko Elena V. 
Published: August 2019

Background::Conventional antitumor Photosensitizers (PS) are normally low toxic in the dark whereas light activation triggers massive cell death (photodynamic therapy, PDT).Objective::To expand the therapeutic potential of PS to dual potency cytocidal agents, taking advantage of the use of bacteriopurpurin for a deeper tissue penetration of light, and suitability of the tetrapyrrolic macrocycle for chemical modifications at its periphery.Methods::Conjugation of a pro-oxidant thiolate Au (I) moiety to the bacteriopurpurin core and evaluation of cytotoxicity in cell culture and in vivo.Results::New water-soluble derivatives showed micromolar cytotoxicity for cultured human tumor cell lines in the dark, including the subline with an altered drug response due to p53 inactivation. Cellular PDT with the selected conjugate, thiolate Au (I)-dipropoxybacteriopurpurinimide (compound 6) with two triphenylphosphine Au fragments, triggered rapid (within minutes) cell death. Damage to the plasma membrane (necrosis) was a hallmark of cell death by compound 6 both in the dark and upon light activation. Furthermore, one single i.v. injection of compound 6 caused retardation of transplanted syngeneic tumors at the tolerable dose. Illumination of tumors that accumulated compound 6 significantly synergized with the effect of 6 in the dark.Conclusion::Complexes of virtually non-toxic, photoactivatable bacteriopurpurin with the gold-containing organic moiety are considered the dual potency antitumor agents, tentatively applicable for intractable tumors.
A Comprehensive Review on Pharmacological Properties of Abrus precatorius L.
Authors: Chopra Vijay , Shriwastva Aishwarya , Khatik Gopal L. , Vyas Manish , Yadav Pramod , Prajapati P.K. , Tomar Bhupendra 
Published: August 2019

Background:Abrus precatorius L. (A. precatorius) is a valuable plant from the family Fabaceae which is a pea family. It is commonly known as Gunja or Jequirity, significantly found throughout India mainly Himalaya to Southern India and Ceylon. It is considered a poisonous plant due to the presence of abrin.Objective:A. precatorius has many pharmacological and biologically active constituents, such as alkaloids, glycosides and flavonoids situated in different parts of the plant. The objective of this review is to provide a retrospective study based on its anticancer potential.Results:Recent studies of A. precatorius are based on the isolation, characterization, and pharmacological evaluation of different secondary metabolites. These constituents possess significant cytotoxic properties against various cancer cell lines including breast, lung, liver, ovarian, prostate and leukaemia. A. precatorius is also reported to have anti-diabetic, anti-microbial, abortifacient, antioxidant, anthelmintic activity, antifertility, nephroprotective, and immunomodulatory activities.Conclusion:The present review summarizes the anticancer potential of A. precatorius and its constituents. However, extensive research is required to establish it as a potent chemotherapeutic agent.
A Historical Data Based Ensemble System for Efficient Stock Price Prediction
Authors: Dwivedi Vijay K. , Gore Manoj M. 
Published: August 2019

Background:
Stock price prediction is a challenging task. The social, economic, political,
and various other factors cause frequent abrupt changes in the stock price. This article proposes a
historical data-based ensemble system to predict the closing stock price with higher accuracy and
consistency over the existing stock price prediction systems.

Objective:
The primary objective of this article is to predict the closing price of a stock for the next
trading in more accurate and consistent manner over the existing methods employed for the stock
price prediction.

Method:
The proposed system combines various machine learning-based prediction models employing
Least Absolute Shrinkage and Selection Operator (LASSO) regression regularization technique
to enhance the accuracy of stock price prediction system as compared to any one of the base
prediction models.

Results:
The analysis of results for all the eleven stocks (listed under Information Technology sector
on the Bombay Stock Exchange, India) reveals that the proposed system performs best (on all defined
metrics of the proposed system) for training datasets and test datasets comprising of all the
stocks considered in the proposed system.

Conclusion:
The proposed ensemble model consistently predicts stock price with a high degree of
accuracy over the existing methods used for the prediction.
HHT-Based Detection Method of Cutter Abnormal Vibration in Spiral Surface Machining
Authors: Li Xin , Zhang Yuliang , Yu Jianping , Deng Xiaolei 
Published: August 2019

Background::
Cutter abnormal vibration occurs frequently during the spiral surface machining
process, and it results in low quality of the finished surface. In order to suppress cutter abnormal
vibration effectively, it is necessary to detect abnormal vibration as soon as possible, but the
analysis and processing of the cutter abnormal vibration signal in spiral surface machining are difficult
because of its complicated components and non-linear non-stationary characteristics. In this paper,
a detection method of cutter abnormal vibration signal based on Empirical Mode Decomposition
(EMD) and Hilbert–Huang Transform (HHT) is proposed to be applied in spiral surface machining.

Method::
First of all, EMD of the cutter vibration signal in the spiral surface machining is performed
to obtain a series of Intrinsic Mode Function (IMF) components in different frequency bands. Secondly,
the variation in the energy of each IMF component in the frequency domain and the correlation
with the original signal are analyzed to obtain the IMF component with the largest amount of
information on abnormal vibration symptom. Finally, the Hilbert transform is conducted on the IMF
component to extract the symptom features of abnormal vibration.

Results::
The Hilbert-Huang spectrogram obtained by Hilbert transform is a two-variable function of
time and frequency, from which the frequency information at any time can be obtained, including
the magnitude and amplitude of the frequency and the corresponding moments appearing, which can
describe the time-frequency characteristics of the non-stationary non-linear signal in detail. Experimental
results show that the HHT based method to analyze the cutter vibration signal in the spiral
surface machining can extract the symptom of abnormal vibration quickly and effectively, and can
detect cutter abnormal vibration rapidly.

Conclusion::
The proposed method based on HHT in this paper is fundamentally different from the
traditional signal time-frequency analysis methods, and has achieved good results in practical applications.
This method could be successfully used in abnormal vibration detection, which could also
provide basis and guarantee for the subsequent suppression of abnormal vibration.
EFFICACY OF LOW-DOSE THROMBOLYSIS WITH INTRAVENOUS ALTEPLASE WITHIN 6 H OF ACUTE ISCHEMIC STROKE ONSET: EVIDENCE FROM SINGLE REFERRAL CENTER IN INDONESIA
Authors: Rasyid Al , Harris Salim , Kurniawan Mohammad , Mesiano Taufik , Hidayat Rakhmad , Herqutanto  , Rahmadhani Meity Asyari 
Published: August 2019

Objective: This study evaluated the efficacy of thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke patients within 6 h of stroke onset.
Methods: This cross-sectional study collected data of patients with ischemic stroke received intravenous thrombolytic therapy with 0.6 mg/kg alteplase within 6 h of onset in Cipto Mangunkusumo General Hospital (Rumah Sakit Cipto Mangunkusumo [RSCM]) between November 2014 and August 2017. Efficacy of the thrombolytic therapy was evaluated using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). NIHSS evaluated on 24 h and 7 d post thrombolytic therapy portrayed clinical outcomes of patients while mRS evaluated on day 30 post-thrombolysis portrayed the functional outcome of patients.
Results: The median NIHSS score decreased on 24 h and 7 d post-thrombolysis. 33.3% patients experienced a reduction of NIHSS score ≥4 on 24 h post thrombolytic therapy. On day 7 following thrombolysis, 57.4% patients had a good clinical outcome. On day 30 follow-up, 55.6% patients had a good functional outcome.
Conclusion: Thrombolysis using 0.6 mg/kg intravenous alteplase within 6 h of onset is effective for acute ischemic stroke patients.
A PRELIMINARY INVESTIGATION OF HTR1A GENE EXPRESSION LEVELS IN AUTISM SPECTRUM DISORDERS
Authors: YAHYA SHAYMAA M. , GEBRIL OLA , ABDEL RAOUF EHAB R. , E. ELHADIDY MOHAMED 
Published: August 2019

Objective: This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children.
Methods: Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin.
Results: The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD.
Conclusion: HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways.
A NEW HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN IN BULK AND TABLET DOSAGE FORM
Authors: SUMA B. V. , R. DEVESWARAN , SHENOY PREMNATH 
Published: August 2019

ABSTRACT
Objective: To develop a new simple, selective and precise high-performance thin layer chromatographic method for determination of Dapagliflozin (DAPA) in bulk and tablet dosage form
Methods: The present study describes development and validation of High performance thin layer chromatographic method for DAPA. The chromatographic separation was carried out on Merck precoated silica gel aluminium plate 60 F254 using Chloroform: Methanol (9:1v/v) as mobile phase. Quantitative determination of drug was carried out by densitometric scanning of plates at 223 nm using Camag TLC Scanner.
Results: The chromatographic condition shows compact band with the retention factor for dapaglifloxin as 0.21 ± 0.004. The method was validated as per ICH guidelines for linearity, accuracy, precision and robustness. Response was found to be linear in the concentration range of 400 ng/ band to 1200 ng/band with linear regression value of 0.9953 with respect to peak area and concentration value The LOD and LOQ was found to be 1.2083 ng/band and 3.6616ng/ band. The percentage assay was found to be 100±0.05.
Conclusion: This method under statistical analysis proved a selective, repeatable and accurate analysis of the drug. This method can be used for quantitative analysis of dapaglifloxin in the bulk drug and in tablet.
How do IRS Resources Affect the Corporate Audit Process?
Authors: Nessa Michelle , Schwab Casey M , Stomberg Bridget , Towery Erin M. 
Published: August 2019

ABSTRACT
This study investigates how Internal Revenue Service resources affect the IRS audit process for publicly traded corporations. Using confidential IRS audit data, we examine the effect of IRS resources on the incidence and magnitude of proposed deficiencies and settlement outcomes. We find that IRS resources are positively associated with both the likelihood and magnitude of proposed deficiencies, but negatively associated with the proportion of proposed deficiencies collected. These results are consistent with the IRS focusing on fewer positions, but targeting positions supported by weaker taxpayer facts when resources are more limited. Based on our findings, we estimate the loss in tax collections from audits of LB&I corporate tax returns alone exceeds the savings from reductions in the IRS enforcement budget. This study contributes to the literature examining the strategic game between tax authorities and corporate taxpayers and has important implications for policymakers, particularly in light of recent IRS budget cuts.
Do Firms That Have a Common Signing Auditor Exhibit Higher Earnings Comparability?
Authors: Chen Jeff Zeyun , Chen Mei-Hui , Chin Chen-Lung , Lobo Gerald J. 
Published: August 2019

ABSTRACT
We hypothesize that if individual auditors possess unique audit styles that they consistently apply to different audit engagements, then client firms with a common signing auditor will exhibit higher earnings comparability. Using a large sample of Chinese firms, we find that client firms report more comparable earnings when they are audited by the same individual auditor than when they are audited by (1) different audit firms, (2) the same audit firm, but different audit offices, and (3) the same audit office, but different individual auditors. The individual auditor style effect is stronger for larger audit firms, senior signing auditors, and signing auditors with more stable teamwork experience. We also document that having a common signing auditor is associated with lower analyst earnings forecast error and dispersion for client firms. This study contributes to the literature by showing that individual auditors have a significant impact on client firms' earnings comparability.
Auditor Reputation Concerns, Legal Liability, and Standards
Authors: Rothenberg Naomi R. 
Published: August 2019

ABSTRACT
This paper studies how legal liability due to negligence can weaken or strengthen an auditor's reputation concerns in the client market to provide high audit effort. A negligence liability rule relies on auditing standards to provide a threshold for the level of due care. When the negligence standard is lax, legal liability can weaken the auditor's reputation incentives, with lower audit effort than without legal liability. If the damage payment is low, noncompliance is less costly, because with compliance, reputational concerns cause the auditor to provide higher costly audit effort than the standard. In this case, investors also prefer noncompliance, and earnings quality is lower than if there were no legal liability damages. When the standard is stringent, noncompliance is less costly for the auditor, and legal liability strengthens reputation incentives. Investors may also prefer noncompliance, and earnings quality is higher than if there were no legal liability damages.
JEL Classifications: M41; M42; D82; M48.
Analysts, Taxes, and the Information Environment
Authors: Kim Sangwan , Schmidt Andrew P. , Wentland Kelly 
Published: August 2019

ABSTRACT
This paper investigates the extent to which analysts incorporate tax-based earnings information into their earnings forecasts relative to other earnings information. We find that analysts' misreaction to tax-based earnings information is distinct from their misreaction to other (nontax) accounting information, on average. We then show that analysts differ in their misestimation of tax and other (nontax) earnings components only when firms have weak information environments; when firms have strong information environments, analysts' forecasts fully incorporate tax-based earnings information and exhibit no difference incorporating tax-based earnings information relative to other accounting information. Our evidence suggests that, on average, forecasting tax-based earnings information is more difficult for analysts relative to forecasting other accounting information. However, access to appropriate information and resources enables analysts to better process tax information. Overall, we contribute to the literature by providing a more complete understanding of the source of analysts' tax-related forecast errors.
JEL Classifications: H25; M41; D82; G14.
Data Availability: Data are available from the public sources identified in the text.
Efficiency of Upper Arch Expansion with the Invisalign System
Authors: Zhou Ning , Guo Jing 
Published: August 2019

ABSTRACTObjectivesTo investigate the efficiency and movement pattern of upper arch expansion using Invisalign aligners. The correlation between the amount of designed expansion and the efficiency of bodily expansion was evaluated, as were the initial molar torque and efficiency of bodily expansion.Materials and MethodsTwenty Chinese adult patients who underwent arch expansion with Invisalign aligners were included in this study. Records of pretreatment (T0 stage) and immediately after completing the expansion phase (T1 stage) were collected, including digital models and cone-beam computed tomography. Dolphin 3D, Geomagic Studio 12.0, and Meazure software were employed to measure data and calculate differences between the expected and actual outcomes.ResultsThere were significant differences between the expected and actual expansion amounts (P&lt; .05). The average expansion efficiencies of the upper canine crown, first premolar crown, second premolar crown, and first molar crown were 79.75 ± 15.23%, 76.1 ± 18.32%, 73.27 ± 19.91%, and 68.31 ± 24.41%, respectively. The average efficiency of bodily expansion movement for the maxillary first molar was 36.35 ± 29.32%. Negative correlations were found between preset expansion amounts and the efficiency of bodily expansion movement (P &lt; .05), and between initial maxillary first molar torque and efficiency of bodily expansion movement (P &lt; .05).ConclusionsAligners could increase the arch width, but expansion was achieved by tipping movement. The evaluation of initial position and preset of sufficient root-buccal torque of posterior teeth were necessary due to the lower efficiency of bodily buccal expansion by the Invisalign system.
Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes
Authors: Zhang Huabing , Goldberg Saveli I. , Hosomura Naoshi , Shubina Maria , Simonson Donald C. , Testa Marcia A. , Turchin Alexander 
Published: August 2019

OBJECTIVE
To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes.

RESEARCH DESIGN AND METHODS
We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationship between frequency of lifestyle counseling (identified using natural language processing of electronic notes) and a composite outcome of death and cardiovascular events during subsequent follow-up.

RESULTS
Among patients with monthly counseling or more, 10-year cumulative incidence of the primary outcome was 33.0% compared with 38.1% for less than monthly counseling (P = 0.0005). In multivariable analysis, higher frequency of lifestyle counseling was associated with lower incidence of the primary outcome (hazard ratio 0.88 [95% CI 0.82–0.94]; P &lt; 0.001).

CONCLUSIONS
More frequent lifestyle counseling was associated with a lower incidence of cardiovascular events and death among patients with diabetes.
Conselho municipal de educação
Authors: Nez Egeslaine de , Almeida Cecídia Barreto , Silva Mara Rubia Aparecida da 
Published: August 2019

Esse artigo objetiva compreender o processo de participação do conselho no monitoramento das ações municipais para o cumprimento do Plano Nacional de Educação. A partir de uma pesquisa bibliográfica e documental, buscou-se por meio das observações in loco das reuniões verificar se os conselhos desenvolvem esse tipo de atividade nos municípios de Montes Claros, Nova Ponte e Barra do Garças. A abordagem para a análise dos dados foi a perspectiva crítica. Pode-se considerar que os conselhos deveriam servir como um reforço para a aplicação e um lastro para reflexões sobre as políticas públicas educacionais, principalmente no que tange ao monitoramento do Plano. Todavia, não foi essa realidade encontrada em todos os conselhos analisados.