bluuebunny/crossref_metadata_2025_split huggingface dataset:
GCMS Analysis of Bioactives of Piper betle Linn. Leaf
Authors: Saini Sapna , Nanda Sanju , Dhiman Anju 
Published: April 2019

Background:
Piper betle Linn. (Piperaceae) is commonly known as “Green gold of India”
due to its high commercial value. It is a Vedic plant used in various traditional system of medicine v.iz.
Ayurveda system of medicine, Yunani system of medicine attributed to various pharmacological activities
v.i.z. antioxidant, anti-inflammatory, analgesic, anti-fertility, antimutagenic etc.

Objectives:
The main objective of the present study is quantitative estimation of the various bioactive
compounds present in leaf of P. betle L. (Bangla variety) by GC-MS analysis using head space method.

Material and Methods:
The vapor sample of leaf of P. betle L. was prepared by head space method for
GCMS analysis. GCMS analysis was carried out using high resolution Thermo scientific TSQ 8000 Gas
Chromatograph-Mass Spectrometer. Helium is used as carrier gas (99.999 %) with a constant flow rate
of 1 ml/min. Total run time was 29.10 min.

Results:
GC-MS analysis revealed the presence of 16 bioactive compounds in leaf of P. betle L.
Eugenol (29.13%), Bakuchiol (11.79%) and α-linalool (14.88%) are the chief bioactive compounds of
leaf. Leaf has been also reported to contain a good percentage of various terpenoids like β-
caryophyllene (7.69), α-muurolene (4.19), α-bisabolene (0.98), etc.

Conclusion:
From GC-MS analysis results it can be concluded that leaf of P. betle L. is a reservoir of
valuable phenolic and susquiterpene compounds. Eugenol chief biomarker compound present leaf is a
versatile remarkable molecule. Due to number of phytoconstituents P. betle L. leaf is recommended as
plant of phytopharmaceutical importance.
Synthesis and Biological Evaluation of Novel 4,5,6,7-Tetrahydrobenzo[D]-Thiazol-2- Yl Derivatives Derived from Dimedone with Anti-Tumor, C-Met, Tyrosine Kinase and Pim-1 Inhibitions
Authors: Mohareb Rafat M. , Abouzied Amr S. , Abbas Nermeen S. 
Published: April 2019

Background:
Dimedone and thiazole moieties are privileged scaffolds (acting as primary pharmacophores)
in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. Thiazole
derivatives are a very important class of compounds due to their wide range of pharmaceutical and therapeutic
activities. On the other hand, dimedone is used to synthesize many therapeutically active compounds. Therefore,
the combination of both moieties through a single molecule to produce heterocyclic compounds will produce
excellent anticancer agents.

Objective:
The present work reports the synthesis of 47 new substances belonging to two classes of compounds:
Dimedone and thiazoles, with the purpose of developing new drugs that present high specificity for tumor
cells and low toxicity to the organism. To achieve this goal, our strategy was to synthesize a series of
4,5,6,7-tetrahydrobenzo[d]-thiazol-2-yl derivatives using the reaction of the 2-bromodimedone with cyanothioacetamide.

Methods:
The reaction of 2-bromodimedone with cyanothioacetamide gave the 4,5,6,7-tetrahydrobenzo[d]-
thiazol-2-yl derivative 4. The reactivity of compound 4 towards some chemical reagents was observed to produce
different heterocyclic derivatives.

Results:
A cytotoxic screening was performed to evaluate the performance of the new derivatives in six tumor
cell lines. Thirteen compounds were shown to be promising toward the tumor cell lines which were further
evaluated toward five tyrosine kinases.

Conclusion:
The results of antitumor screening showed that many of the tested compounds were of high inhibition
towards the tested cell lines. Compounds 6c, 8c, 11b, 11d, 13b, 14b, 15c, 15g, 21b, 21c, 20d and 21d were
the most potent compounds toward c-Met kinase and PC-3 cell line. The most promising compounds 6c, 8c, 11b,
11d, 13b, 14b, 15c, 15g, 20c, 20d, 21b, 21c and 21d were further investigated against tyrosine kinase (c-Kit, Flt-3,
VEGFR-2, EGFR, and PDGFR). Compounds 6c, 11b, 11d, 14b, 15c, and 20d were selected to examine their
Pim-1 kinase inhibition activity the results revealed that compounds 11b, 11d and 15c had high activities.
Novel Pyrazolo[3,4-d]pyrimidines as Potential Cytotoxic Agents: Design, Synthesis, Molecular Docking and CDK2 Inhibition
Authors: Maher Mai , Kassab Asmaa E. , Zaher Ashraf F. , Mahmoud Zeinab 
Published: April 2019

Background:
Pyrazolo[3,4-d]pyrimidine scaffold was reported to possess potent cytotoxic and CDK2
inhibitory activity as analogue of roscovitine.

Objective:
To design and synthesize novel 1-(4-flourophenyl)pyrazolo[3,4-d]pyrimidine derivatives as bioisosters
of roscovitine with potential cytotoxic and CDK2 inhibitory activity.

Methods:
A series of novel 1-(4-flourophenyl)pyrazolo[3,4-d]pyrimidines were designed and synthesized.
Structural elucidation for all the newly synthesized compounds was achieved through performing MS, 1H NMR,
13C NMR and IR spectral techniques. Eight compounds were screened for their cytotoxic activity by National
Cancer Institute (USA) against 60 different human cancer cell lines. Compounds 2a, 4, 6, 7b, 8a and 8b were
further studied through the determination of their IC50 values against the most sensitive cell lines. The inhibitory
activities of compounds 2a and 4 were evaluated against CDK2 enzyme.

Results:
Compound 4 exhibited the most prominent broad-spectrum cytotoxic activity against 42 cell lines representing
all human cancer types showing growth inhibition percentages from 53.19 to 99.39. Compound 2a
showed promising selectivity against several cell lines. Moreover, all the test compounds exhibited potent cytotoxic
activity in nanomolar to micromolar range with IC50 values ranging from 0.58 to 8.32μM. Compound 2a
showed significant cytotoxic activity against CNS (SNB-75), lung (NCI-H460) and ovarian (OVCAR-4) cancer
cell lines with IC50 values 0.64, 0.78 and 1.9μM, respectively. Compound 4 showed promising potency against
leukemia (HL-60) and CNS (SNB-75) cell lines (IC50 = 0.58 and 0.94μM, sequentially). Moreover, the antiproliferative
activities of compounds 2a and 4 appeared to correlate well with their ability to inhibit CDK2 at
sub-micromolar level (IC50 = 0.69 and 0.67μM, respectively) that were comparable to roscovitine
(IC50=0.44μM). The Molecular docking results revealed that compound 4 interacted with the same key amino
acids as roscovitine in the active site of CDK2 enzyme with a marked docking score (-14.1031 kcal/mol).

Conclusion:
1-(4-Flourophenyl)pyrazolo[3,4-d]pyrimidine is a promising scaffold for the design and synthesis
of potent cytotoxic leads.
Evaluación de la adherencia al tratamiento de los pacientes menores de 18 años con fibrosis quística en el Hospital Infantil Dr. Robert Reid Cabral de Santo Domingo, República Dominicana, durante el período febrero-abril 2018
Authors: Cordero-Oñate Leandra , García-García Yanira , Alcántara Acosta Baylin , Fernández Troncoso Gisselle Marie , George Flores Jennifer , Mercado Jhomayri , Pugibet Enrique 
Published: April 2019

Introducción: la fibrosis quística es una enfermedad hereditaria autosómica recesiva que afecta las células que producen el sudor, el moco y los jugos digestivos. Esta patología afecta a 1 de cada 2.000-3.500 nacidos vivos, siendo la más frecuente de las enfermedades hereditarias mortales en la población de raza blanca.
Objetivo: evaluar la adherencia al tratamiento de los pacientes menores de 18 años con fibrosis quística en el Hospital Infantil Dr Robert Reid Cabral de Santo Domingo, República Dominicana, durante el período febrero - abril 2018.
Material y métodos: estudio prospectivo, descriptivo y de corte transversal en el que se realizaron cuestionarios a 32 guardianes de pacientes del servicio de neumología pediátrica con fibrosis quística de un hospital.
Resultados: el nivel de adherencia al tratamiento fue bajo, representado por un 41%. La principal razón de no adherencia al tratamiento fue el alto costo monetario con un 61%. Con respecto a la adherencia y nivel socioeconómico, se mostró que el nivel socioeconómico más frecuente fue el D+, el cual se encuentra en la mitad baja de la escala y la mayoría de pacientes eran no adherentes. La vía de administración de tratamiento preferida fue la oral con un 78%. La mayoría de los pacientes tienen un nivel bajo de conocimiento del tratamiento, representado por un 32%.
Conclusiones: los pacientes contaban con una baja adherencia al tratamiento, debido al alto costo monetario de los medicamentos. La mayoría de ellos preferían tratamientos administrados por vía oral, pertenecían al nivel socioeconómico D+ y contaban con un conocimiento bajo acerca del tratamiento.
Evaluación del consumo de antibióticos con y sin prescripción médica en infantes menores de cinco años en la comunidad de Paya en medio-Baní, durante el período agosto-octubre 2018
Authors: Almonte Quiñones Cristhian J. , Martínez Jiménez Penélope , Valdez Aquino Cástulo J. , Contreras Cristina , López Emilton 
Published: April 2019

Introducción: la resistencia antibiótica se está perfilando como una grave amenaza en todo el mundo. Cada día están propagándose a nivel mundial nuevos mecanismos de resistencia que ponen en peligro nuestra capacidad para tratar las enfermedades infecciosas.
Objetivo: evaluar el consumo de antibióticos con y sin prescripción médica de los niños menores de 5 años en la comunidad de Paya en medio-Baní, durante el periodo agosto-octubre 2018.
Material y métodos: estudio prospectivo, descriptivo, observacional, de corte transversal con una muestra de 68 niños menores de 5 años.
Resultados: se determinó que el 46% de la muestra utilizó antibióticos en los últimos 3 meses. El 68% de los infantes que consumieron antibióticos lo obtuvieron bajo prescripción médica y el 32% lo obtuvieron por venta libre. El antibiótico de mayor consumo fue la Amoxicilina. El motivo que mayor uso de antibiótico requirió fue relacionado a síntomas del aparato respiratorio.
Conclusiones: en un corto período de tiempo de tan solo 3 meses, menores de 5 años fueron altamente expuestos a antibióticos. Debido a que su uso puede contribuir a la resistencia bacteriana, estos resultados tienen implicaciones importantes para la educación en salud pública y para la normativa de ventas de antibióticos en la República Dominicana.
Intoxicación pediátrica por Paraquat: presentación de caso, Hospital Infantil Dr. Robert Reid Cabral (HIRRC), República Dominicana
Authors: Contreras Cristina , Corona Lisandra , Domínguez Norys , Mejía Sang Miguel 
Published: April 2019

Introducción: el paraquat (dicloruro de 1,1’-dimetil-4,4’-bipiridilo) es un químico tóxico utilizado mundialmente como herbicida. La etiología de la intoxicación por paraquat se debe en su mayoría a la ingestión suicida. Fisiopatológicamente, el pulmón, el hígado y el riñón son los órganos especialmente afectados por el paraquat debido a su alta saturación de oxígeno. La letalidad por intoxicación por paraquat es muy alta, cerca del 80%, siendo la fibrosis pulmonar la causa más frecuente de muerte.
Objetivos: el siguiente documento tiene la intención de identificar los principales signos y síntomas que constituyen la presentación clínica de la intoxicación por paraquat en un paciente pediátrico. A pesar de la limitada bibliografía, se pretendió hacer una comparación de la presentación y el progreso clínico con otros casos de intoxicación por paraquat.
Material y Métodos: se expone el caso clínico de una joven de 15 años, la cual ingirió aproximadamente 250 ml de paraquat con intención autolítica. La misma presentó inicialmente afección en el tracto gastrointestinal, seguido de alteración de las pruebas hepáticas, renales y pancreáticas, y dificultad respiratoria.
Conclusiones: luego de describir la presentación clínica de nuestra paciente, y de compararla con la de otros casos similares, concluimos que el diagnóstico precoz y exhaustivo de la intoxicación por paraquat reduce significativamente su mortalidad debido a la actual inexistencia de un antídoto específico para dicho envenenamiento. Asimismo, recomendamos tener siempre presente la intoxicación por paraquat al momento de recibir pacientes con la presentación característica luego de la ingesta de sustancias desconocidas.
Características clínico epidemiológicas de los casos de tuberculosis infantil diagnosticados en el Hospital Infantil Dr. Robert Reid Cabral 2007- 2012
Authors: Melgen Ricardo Elías , Pantaleón Elsa Camilo , Lazala J Adria , Abreu B. Aimee 
Published: April 2019

Introducción: la TB infantil es considerada como un evento centinela de transmisión de la enfermedad y su control no ha sido una prioridad. República Dominicana es un país de elevada incidencia de TB y los datos reportados de TB infantil apuntan a una baja detección de casos y un sub diagnóstico.
Objetivo: conocer las características clínico epidemiológicas de los casos de Tuberculosis infantil diagnosticados en el Hospital Infantil Dr. Robert Reid Cabral. 2007- 2012.
Métodos: estudio descriptivo. Se revisaron los expedientes clínicos de los pacientes menores de 15 años de edad diagnosticados y seguidos en el programa de tuberculosis infantil del Hospital Infantil Robert Reid Cabral en los años 2007-2012.
Resultados: se evaluaron 249 pacientes, 81% con diagnóstico de TB infantil y 19% con Infección Latente por Tuberculosis. 56.2% tenía menos de 5 años de edad y 61.4% tenían cicatriz de vacuna BCG. 63.5% de los casos refería el contacto con un caso de Tuberculosis, y en el 70.0% era intradomiciliario. La manifestación pulmonar representó el 63.4% de los casos TB y el 27.3% tenían baciloscopia positiva.
Conclusión: existen diferencias importantes en el diagnóstico y manejo de la tuberculosis infantil y la TB en el adultos. Estas deben ser considerados en la implementación de estrategias para el control; con acciones integradas, un enfoque orientado no solo al niño, sino también a la familia y tomando en consideración los determinantes sociales
A Decentralized Personal Data Store based on Ethereum: Towards GDPR Compliance
Authors: Alessi Marco , Camillò Alessio , Giangreco Enza , Matera Marco , Pino Stefano , Storelli Davide 
Published: April 2019

Sharing personal data with service providers is a fundamental resource for the times we live in. But data sharing represents an unavoidable issue, due to improper data treatment, lack of users' awareness to whom they are sharing with, wrong or excessive data sharing from end users who ignore they are exposing personal information. The problem becomes even more complicate if we try to consider the devices around us: how to share devices we own, so that we can receive pervasive services, based on our contexts and device functionalities. The European Authority has provided the General Data Protection Regulation (GDPR), in order to implement protection of sensitive data in each EU member, throughout certification mechanisms (according to Art. 42 GDPR). The certification assures compliance to the regulation, which represent a mandatory requirement for any service which may come in contact with sensitive data. Still the certification is an open process and not constrained by strict rule. In this paper we describe our decentralized approach in sharing personal data in the era of smart devices, being those considered sensitive data as well. Having in mind the centrality of users in the ownership of the data, we have proposed a decentralized Personal Data Store prototype, which stands as a unique data sharing endpoint for third party services. Even if blockchain technologies may seem fit to solve the issue of data protection, because of the absence of a central authority, they lay to additional concerns especially relating such technologies with specifications described in the regulation. The current work offers a contribution in the advancements of personal data sharing management systems in a distributed environment by presenting a real prototype and an architectural blueprint, which advances the state of the art in order to meet the GDPR regulation. Address those arisen issues, from a technological perspective, stands as an important challenge, in order to empower end users in owning their personal data for real.
An den Grenzen der Vernunft: Beamte und ›Barbaren‹ in den Peripherien Lateinamerikas, 18.–19. Jahrhundert
Authors: Hölck Lasse 
Published: April 2019

Abstract
This contribution investigates the role of emotions for the administration of indigenous people in the Latin American periphery, considered “barbarians” by colonial and republican officials. Drawing on case studies from Northwest Mexico and the Southern Cone, the article examines the Spanish-European self-image as “people of reason” vis-á-vis indigenous “people without reason” or “people of custom”. The concept of trust is employed to explore the boundaries and overlappings between emotion and rationality in interethnic relations during colonial and republican times. Giving examples from archival material such as letters and reports of state agents, this paper concludes that there was no monopoly on rationality, as claimed by the public officials, but always a possibility to establish trusting relationships between indigenous groups and state society.
Litigious Paranoia: Sense of Justice, Bureaucracy, and Media
Authors: Gaderer Rupert 
Published: April 2019

Abstract
At the end of the 18th century, reports were made of unusual and curious legal cases in which the plaintiffs were moved by a self-destructive obsession. These excessive desires expressed themselves in the fact that these people were involved in countless lawsuits and vied in vain for their rights in court. These plaintiffs were people who studied the law obsessively, meticulously filed suit after suit, and continuously troubled civil servants with unjustified legal demands. The Prussian bureaucracy gave these plaintiffs a name: ›Querulanten‹ (from Latin: queri, to complain). This paper deals with the history of these troublemakers, and more particularly, with the goal of understanding the source, development, and the continuing existence of querulency as a connection between media, knowledge, and emotions.
The Bureaucracy of Honor. The Habsburg Consular Service and the History of Emotions
Authors: Johnson Alison Frank 
Published: April 2019

Abstract
I use the personnel files of three consuls in the Austro-Hungarian foreign service to consider the ways Habsburg bureaucracy recorded the emotional lives of civil servants. Consuls were expected to interact with Habsburg subjects and other civilians dispassionately and objectively. But conflicts that occurred in their ‘free time,’ outside the consulates, spilled over into their professional time. The resolution of those conflicts involved their colleagues in the consulates and administrators in Vienna. While showing emotion in interactions inside the consulate was frowned upon, responding to attacks on personal honor with the strongest of emotions was expected of an Austro-Hungarian “gentleman.” Consuls had to abide by both the standards of their profession and the standards for “men of honor” (Ehrenmänner) that had been codified with the officer corps in mind. The recognition that both roles were compatible shows the repackaging of certain kinds of “emotion” as professional requirements, rather than excesses.
Gefühlshaushalt in Mähren: Leistungsverwaltung, Landesschulden und Loyalitäten nach 1905
Authors: Osterkamp Jana 
Published: April 2019

Abstract
In 1910 the Crownland Moravia was confidentially granted a 5 million loan by the Viennese government. Moravia was heavily indebted and spent extensive expenditures for schooling, infrastructure and social welfare. The secret loan to Moravia was just one part of the multi-tiered system of fiscal flows in late Imperial Austria that was subject to emotionally heated debates. Since the budgetary power in the regional, transnational and imperial arenas came with determining the political priorities there, negotiations of the budget mirrored conflicting political camps often divided along national lines. On the imperial level, however, the same politicians forged transnational cooperation and new forms of transnational revenue sharing. Utterances of emotions were made more objective the higher the political level the crownland’s leading officials dealt with. The emotional side of fiscal politics, however, can be seen as a driving force in prioritising certain policy fields.
Feeling like a State. The Sentiments Tide of Swiss Diplomacy through the Eye of the Algorithm
Authors: Ourednik André , Koller Guido , Fleer Peter , Nellen Stefan 
Published: April 2019

Abstract
Can emotions be observed throughout the years at the regional scale of continents and countries? Does variation in their intensity correlate with historical events and with the evolution of diplomatic and administrative practices? If so, who is the subject of emotion? We seek answers by a remote reading analysis of the reports of Swiss ambassadors in the first half of the 20th century. We examine the conditions under which super-individual subjects of emotion can be aggregated from large textual datasets, and propose a theoretical framework for their interpretation. In specific examples, we show how algorithmic sentiment analysis let us identify the exceptionally expressive language of the Swiss ambassador in Tokyo during World War 2, or the posture of the Swiss administration with regard to the social movements in Scandinavia. Our findings yield both methodological recommendations and theoretical bridges between various disciplines concerned with emotions and their expression in written documents.
Influence of seasonal factors in the earned value of construction
Authors: Ruiz-Fernández Juan Pedro , Benlloch Javier , López Miguel A. , Valverde-Gascueña Nelia 
Published: April 2019

Abstract
The objectives in each construction process can be multiple. However, the constructions have to be carried out under some restrictions concerning price and terms. They constitute some strategic and interdependent goals. In other words, “time is money”. Several papers support that seasonal effects influence the execution rate of construction. Thus, most of them try to improve the forecasts by evaluating and joining them to the planning, although always measuring their influence indirectly. In this paper, we suggest a methodology to directly measure the influence of the seasonal factors as a whole over the earned value of construction. Additionally, we apply it to a certain case study regarding the subsidised housing of public promotion in the Castilla-La Mancha region (Spain). It is worth mentioning that our results are clarified: we have calculated the average monthly production for each month a year with respect to the annual monthly mean. Moreover, the differences regarding the average monthly production we have contributed are quite significant, and hence they have to be taken into account for each earned value forecast so that a project becomes reliable.
Axisymmetric Torsion of an Elastic Layer Sandwiched between Two Elastic Half-Spaces with Two Interfaced Cracks
Authors: Madani Fateh , Kebli Belkacem 
Published: April 2019

Abstract
The present article examines the problem related to the axisymmetric torsion of an elastic layer by a circular rigid disc at the symmetry plane. The layer is sandwiched between two similar elastic half-spaces with two penny-shaped cracks symmetrically located at the interfaces between the two bonded dissimilar media. The mixed boundary-value problem is transformed, by means of the Hankel integral transformation, to dual integral equations, that are reduced, to a Fredholm integral equation of the second kind. The numerical methods are used to convert the resulting system to a system of infinite algebraic equations. Some physical quantities such as the stress intensity factor and the moment are calculated and presented numerically according to some relevant parameters. The numerical results show that the discontinuities around the crack and the inclusion cause a large increase in the stresses that decay with distance from the disc-loaded. Furthermore, the dependence of the stress intensity factor on the disc size, the distance between the crack and the disc, and the shear parameter is also observerd.