bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pristine Approach for the Prominent Premaxilla in Bilateral Cleft Lip and Palate (BCLP) Cases
Authors: Monga Nitika , Kharbanda Om P. 
Published: March 2019

Objective: The neonate premaxilla in bilateral cleft lip and palate is often protruding and displaced laterally. Surgeons prefer the premaxilla to be repositioned and centralized to allow a tension-free primary lip repair. This report describes the fabrication of a premaxillary bonnet appliance with silicone material and its successful use in 2 cases of bilateral cleft lip and palate (BCLP). Patients, Participants: Two male BCLP patients of ages 34 days and 10 days, respectively. Interventions: Nonsurgical repositioning of the premaxillary segment using silicone cup–bonnet appliance. Results: The duration of active treatment by silicone appliance was 36 days in case 1 and 75 days in case 2. The retention period was 2 months and 3 months, respectively. The appliance made of room temperature vulcanizing (RTV) silicone is flexible and softer in comparison to the rigid conventional acrylic appliance and is therefore almost atraumatic. A gentler appliance resulted in enhanced compliance and acceptance by the neonates. There was a noticeable change in the position of the discernible asymmetric premaxilla. Analysis of frontal facial photographs revealed an angular change in the position of the premaxilla (C) by 12° in case 1 and 6° in case 2 in reference to the midfacial plane. Conclusion: This silicone appliance provides enhanced compliance and improved retention compared to acrylic appliance since it is a more gentle, flexible, and less traumatic alternative to a rigid acrylic appliance. Further, the RTV silicone appliance can be 3-dimensionally printed for better accuracy following intraoral scanning and thus eliminating the need for impression making in cleft newborns.
The knowledge of Cormack–Lehane intubation grade and intensive care unit outcome
Authors: Nanjayya Vinodh B , Hebel Christopher J , Kelly Patrick J , McClure Jason , Pilcher David 
Published: March 2019

Background For patients on invasive mechanical ventilation (MV), it is unclear if knowledge of intubation grade influences intensive care unit (ICU) outcome. We aimed to determine if there was an independent relationship between knowledge of intubation grade during ICU admission and in-hospital mortality. Methods We performed a retrospective cohort study of all patients receiving invasive MV at the Alfred ICU between December 2011 and February 2015. Demographics, details of admission, the severity of illness, chronic health status, airway detail (unknown or known Cormack–Lehane (CL) grade), MV duration and in-hospital mortality data were collected. Univariable and multivariable analyses were conducted to assess the relationship. The primary outcome was in-hospital mortality, and the secondary outcome was the duration of MV. Results Amongst 3556 patients studied, 611 (17.2%) had an unknown CL grade. Unadjusted mortality was higher in patients with unknown CL grade compared to known CL grade patients (21.6% vs. 9.9%). After adjusting for age, sex, severity of illness, type of ICU admission, cardiac arrest, limitations to treatment and diagnosis, having an unknown CL grade during invasive MV was independently associated with an increase in mortality (adjusted OR 1.5, 95% CI 1.14–1.98, p < 0.01). Conclusion Amongst ICU patients receiving MV, not knowing CL grade appears to be independently associated with increased mortality. This information should be communicated and documented in all patients receiving MV in ICU.
Novel Surgical Technique for Repair of Zygomatic Fractures: Lever Technique
Authors: Cinal Hakan , Barin Ensar Zafer , Çakmak Mehmet Akif , Kara Murat , Yilmaz Kerem , Tan Onder 
Published: March 2019

Background: Zygoma is a very crucial component for the anteroposterior positioning of the midface and for the maintenance of facial contours. Zygomatic fractures are considered as the second most common type of facial fractures following nasal fractures. We have developed a new reduction technique called “lever,” which is based on the application of lifting force as an alternative to the methods in which the pulling force is applied. Patients: Over a 12-year period, 90 patients were treated with minimal access approach and 130 patients were treated with open reduction internal fixation (ORIF), using the lever technique. Results: In the follow-up period, no complications occurred in any of the patients who underwent minimal access approach. Miniplate removal operation was performed in 3 of the patients. Enophthalmos developed in one patient. Since 4 of the 7 suboptimal reduction patients did not experience any functional or cosmetic problems, no treatment was necessary and the remaining 3 patients underwent fat graft due to the presence of malar depression. Conclusion: This minimally invasive surgical procedure we have developed can be successfully used both in the minimal access approach and in ORIF, especially in delayed cases. We recommend this method due to the reasons that it is safe to conduct, easy to learn, fast to apply, simple to perform, and also economical to deploy.
Treatment of Lateral Epicondylitis With Autologous Blood, Platelet-Rich Plasma, or Corticosteroid Injections: A Systematic Review of Overlapping Meta-analyses
Authors: Houck Darby A. , Kraeutler Matthew J. , Thornton Loree B. , McCarty Eric C. , Bravman Jonathan T. 
Published: March 2019

Background: Previous meta-analyses have been conducted to compare outcomes of various treatment injections for lateral epicondylitis (LE), including corticosteroid injection (CSI) and autologous blood products such as autologous blood (AB) and platelet-rich plasma (PRP). Purpose: To conduct a systematic review of overlapping meta-analyses comparing different injection treatments (CSI, AB, PRP) for LE to determine which meta-analyses provide the best available evidence. Study Design: Systematic review; Level of evidence, 2. Methods: A systematic review was performed by searching PubMed, Embase, and the Cochrane Library to locate meta-analyses that compared clinical outcomes of CSI, AB, and PRP for the treatment of LE. Search terms included “injection,” “corticosteroid,” “platelet-rich plasma,” “autologous blood,” “tennis elbow,” “lateral epicondylitis,” and “meta-analysis.” Results were reviewed to determine study eligibility. Patient outcomes were extracted from these meta-analyses. Meta-analysis quality was assessed with the Oxman-Guyatt and Quality of Reporting of Meta-analyses (QUOROM) systems. The Jadad decision algorithm was then used to determine which meta-analyses provided the best level of evidence. Results: Nine meta-analyses (two level 1 studies, seven level 2 studies) containing 8656 patients met the eligibility criteria. Seven meta-analyses found that autologous blood products such as AB and PRP significantly improved pain and elbow function in the intermediate term (12-26 weeks), while 4 studies found that CSI effectively relieved pain and improved elbow function in the short term (<12 weeks). The study by Arirachakaran et al in 2016 received the highest QUOROM and Oxman-Guyatt scores; therefore, this meta-analysis appears to have the highest level of evidence. In addition, this study was rated the highest-quality study in this systematic review according to the Jadad decision algorithm. Lower-quality meta-analyses indicated that dosage, number of injections, and differences in therapeutic duration between CSI and autologous blood products may be essential factors in determining the appropriate treatment injection protocol for LE. Conclusion: The current best available evidence suggests that CSI improves functional outcomes and pain relief in the short term, while AB and PRP are the most effective treatments in the intermediate term.
Comparison of rebound tonometry and non-contact airpuff tonometry to Goldmann applanation tonometry
Authors: Demirci Goktug , Erdur Sevil Karaman , Tanriverdi Cafer , Gulkilik Gokhan , Ozsutçu Mustafa 
Published: March 2019

Purpose: The aim of this study was to compare the intraocular pressure measurements obtained from healthy subjects with the rebound tonometry, non-contact airpuff tonometry, and Goldmann applanation tonometry in different age groups. Methods: A total of 180 eyes of 90 healthy subjects were included in the study. According to the subjects’ ages, the eyes were categorized into three groups: group 1 (age: 7–17 years), group 2 (age: 18–40 years), and group 3 (age: 41–75 years). Intraocular pressure was measured on each subject always in the same order: rebound tonometry, non-contact airpuff tonometry, and Goldmann applanation tonometry. Central corneal thickness values were obtained using ultrasonic pachymetry. One-way repeated-measures analysis of variance, Pearson’s correlation coefficient, and Bland–Altman analysis were used for the statistical assessment. Results: The mean corneal thickness was found to be 604 ± 13 µm, 546 ± 15 µm, and 547 ± 15 µm in group 1, group 2, and group 3, respectively. Non-contact airpuff tonometry was significantly higher than both Goldmann applanation tonometry and rebound tonometry measurements in all groups ( p < 0.001, for all). No statistical difference between Goldmann applanation tonometry and rebound tonometry measurements was found in group 1 ( p = 0.248), group 2 ( p = 0.63), and group 3 ( p = 0.126). There was a significant positive correlation in the meaning of intraocular pressure measurements between rebound tonometry and non-contact airpuff tonometry; non-contact airpuff tonometry and Goldmann applanation tonometry; and Goldmann applanation tonometry and rebound tonometry in all groups. Conclusion: As a result, without need for topical anesthesia, fast measurement and ease-of-use rebound tonometry is a reliable alternative to Goldmann applanation tonometry in different age groups.
Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population
Authors: Sánchez María Patricia , Prieto Carem , Mujica Endrina , Vergara Kendry , Valencia Enifer , Villalobos Eudymar , Medina Mayerlim , Parra Michael , D'Addosio Rosanna , Hoedebecke Kyle , Rodríguez Johel E. , Bermudez Valmore 
Published: March 2019

Background: Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the ADIPOQ gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the ADIPOQ gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela. Methods: A total of 90 subjects who attended the Center for Metabolic Endocrine Research "Dr. Félix Gómez" were enrolled for this study, 46 of which had MS-DM2 and 44 of which were healthy control individuals. Genomic DNA was extracted from blood samples and PCR-restriction fragment length polymorphism analysis was carried out for the promoter region of the ADIPOQ gene. Likewise, the +45 T> G polymorphism was identified and correlated with MS and DM2 in the studied population. Results: The most frequent allele in both groups was the T allele, and the predominant genotype was homozygous T/T (79%). Genotypes with heterozygous T/G and G/G homozygous polymorphism were more frequent in the control group than in the MS-DM2 group. Regarding the individuals with T/G and G/G genotypes, statistically significant lower mean values ​​were found for fasting glucose, total cholesterol, triacylglycerides, abdominal circumference, and for the medians of systolic and diastolic blood pressure. Odds ratio were calculated for the presence or absence of MS and DM2. Conclusions: The results suggested that the presence of the G allele exerts a protective effect on the carrier individuals, thus avoiding the appearance of the aforementioned metabolic alterations.
Studying the youth interests through the thematic repertoire of student communication: a case study of Vkontakte social network
Authors: Brazevich Svyatoslav S. , Safronova Zhanna S. , Brazevich Dmitry S. , Matyukha Denis V. 
Published: March 2019

The article substantiates the relevance of a sociological approach to the study of young students' interests in social networks. The authors analyze the results of a study involving young students who use the thematic communication repertoire in the Vkontakte network’s social groups. The study applies IT methods for processing and analyzing biographical data, analysis and statistics methods, and machine learning. The sample consists of 171,972 unique participants who joined the network’s social groups. The authors draw up a rating of groups on various topics based on the number of group participants, present the results of the analysis of student thematic repertoire and reveal the interests of the group participants. The article describes general and specific directions of student interests in different universities, explores the features of interactions between the participants in popular groups, and defines gender differences and various cognitive orientations depending on the place of studies. The authors provide insight into the nature of the cognitive orientation of student interests and the possibilities to influence the interests through certain content, and the weak student activity in the “corporate” social groups of the universities.
Laboratory medicine: health evaluation in elite athletes
Authors: Lombardo Barbara , Izzo Viviana , Terracciano Daniela , Ranieri Annaluisa , Mazzaccara Cristina , Fimiani Fabio , Cesaro Arturo , Gentile Luca , Leggiero Eleonora , Pero Raffaela , Izzo Barbara , D’Alicandro Andrea Carlo , Ercolini Danilo , D’Alicandro Giovanni , Frisso Giulia , Pastore Lucio , Calabrò Paolo , Scudiero Olga 
Published: March 2019

Abstract
The need to evaluate the health status of an athlete represents a crucial aim in preventive and protective sports science in order to identify the best diagnostic strategy to improve performance and reduce risks related to physical exercise. In the present review we aim to define the main biochemical and haematological markers that vary significantly during and after sports training to identify risk factors, at competitive and professional levels and to highlight the set up of a specific parameter’s panel for elite athletes. Moreover, we also intend to consider additional biomarkers, still under investigation, which could further contribute to laboratory sports medicine and provide reliable data that can be used by athlete’s competent staff in order to establish personal attitudes and prevent sports injuries.
Crystal structure of (E)-2-(1-((2-aminophenyl)imino)ethyl)-5-fluorophenol, C14H13FN2O
Authors: Bai Ling , Hong Yong , Liu Wei , Wu Jie 
Published: March 2019

Abstract
C14H13FN2O, orthorhombic, Pna21 (no. 33), a = 7.1841(6) Å, b = 23.3361(17) Å, c = 7.1672(5) Å, V = 1201.57(16) Å3, Z = 4, R
gt(F) = 0.0437, wR
ref(F
2) = 0.1112, T = 293(2) K.
The crystal structure of 2-(4-chloro-2,6-dinitrophenyl)-1-(4-chloro-3,5-dinitrophenyl)diazene 1-oxide, C12H4Cl2N6O9
Authors: Cao Junyan , Wang Jianlong , Li Min , Zhang Ke , Li Shuai , Wan Zhen 
Published: March 2019

Abstract
C12H4Cl2N6O9, monoclinic, C2/c (no. 15), a = 50.136(3) Å, b = 8.1074(5) Å, c = 15.9816(11) Å, β = 91.927(2)°, V = 6492.4(7) Å3, Z = 16, R
gt(F) = 0.0427, wR
ref(F
2) = 0.0969, T = 173(2) K.
Bayesian Genomic Prediction with Genotype × Environment Interaction Kernel Models
Authors: Cuevas Jaime , Crossa José , Montesinos-López Osval A , Burgueño Juan , Pérez-Rodríguez Paulino , de los Campos Gustavo 
Published: March 2019

Abstract
The phenomenon of genotype × environment (G × E) interaction in plant breeding decreases selection accuracy, thereby negatively affecting genetic gains. Several genomic prediction models incorporating G × E have been recently developed and used in genomic selection of plant breeding programs. Genomic prediction models for assessing multi-environment G × E interaction are extensions of a single-environment model, and have advantages and limitations. In this study, we propose two multi-environment Bayesian genomic models: the first model considers genetic effects (u) that can be assessed by the Kronecker product of variance–covariance matrices of genetic correlations between environments and genomic kernels through markers under two linear kernel methods, linear (genomic best linear unbiased predictors, GBLUP) and Gaussian (Gaussian kernel, GK). The other model has the same genetic component as the first model (u) plus an extra component, f, that captures random effects between environments that were not captured by the random effects u. We used five CIMMYT data sets (one maize and four wheat) that were previously used in different studies. Results show that models with G × E always have superior prediction ability than single-environment models, and the higher prediction ability of multi-environment models with u and f over the multi-environment model with only u occurred 85% of the time with GBLUP and 45% of the time with GK across the five data sets. The latter result indicated that including the random effect f is still beneficial for increasing prediction ability after adjusting by the random effect u.
Mutation Profile of ResectedEGFR-Mutated Lung Adenocarcinoma by Next-Generation Sequencing
Authors: Zhao Ze-Rui , Lin Yao-Bin , Ng Calvin S.H. , Zhang Rong , Wu Xue , Ou Qiuxiang , Chen Wendan , Zhou Wen-Jie , Lin Yong-Bin , Su Xiao-Dong , Shao Yang W. , Long Hao 
Published: March 2019

AbstractBackgroundThe efficacy of adjuvant targeted therapy for operable lung cancer is still under debate. Comprehensive genetic profiling is needed for detecting co-mutations in resected epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC), which may interfere the efficacy of adjuvant tyrosine kinase inhibitor (TKI) treatment.Materials and MethodsMutation profiling of 416 cancer-relevant genes was conducted for 139 resected stage I–IIIa lung ADCs with EGFR mutations using targeted next-generation sequencing. Co-mutation profiles were systematically analyzed.ResultsRare EGFR alterations other than exon 19 deletion and L858R, such as L861Q (∼3%) and G719A (∼2%), were identified at low frequencies. Approximately 10% of patients had mutations in EGFR exon 20 that could confer resistance to first-generation TKIs. Ninety-one percent of patients harbored at least one co-mutation in addition to the major EGFR mutation. TP53 was the top mutated gene and was found more frequently mutated at later stage. Markedly, NF1 mutations were found only in stage II–III ADCs. Conversely, RB1 mutations were more frequent in stage I ADCs, whereas APC mutations were observed exclusively in this group. Thirty-four percent of patients with EGFR TKI-sensitizing mutations had genetic alterations involving EGFR downstream effectors or bypass pathways that could affect the response to EGFR TKIs, such as PIK3CA, BRCA1, and NOTCH1.ConclusionOperable lung ADCs with EGFR TKI-sensitizing mutations are associated with a high proportion of co-mutations. Mutation profiling of these resected tumors could facilitate in determining the applicability and efficacy of adjuvant EGFR TKI therapeutic strategy.Implications for PracticeThe efficacy of adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy for lung cancer harboring EGFR mutation after surgical resection is still under debate. Next-generation sequencing of 416 cancer-relevant genes in 139 resected lung cancers revealed the co-mutational landscape with background EGFR mutation. Notably, the study identified potential EGFR TKI-resistant mutations in 34.71% of patients with a drug-sensitizing EGFR mutation and who were naive in terms of targeted therapy. A comprehensive mutation profiling of these resected tumors could facilitate in determining the applicability and efficacy of adjuvant EGFR TKI therapeutic strategy for these patients.
Nanoyapılı TiO2 Film Yüzeyinde TiO2/ZnO ve TiO2/CuO Heteroyapıların Oluşturulması ve Fotokatalitik Aktivitelerinin İncelenmesi
Authors: DİKİCİ Tuncay , YURDDAŞKAL Metin 
Published: March 2019

Bu çalışmada, saf titanyum yüzeyinde üç farklı aşamada TiO2/ZnO ve TiO2/CuO heteroyapıları oluşturularak her bir farklı oksit bileşiğin fotokatalitik performansları incelenmiştir. İlk olarak; elektrokimyasal anotlama tekniği ile saf titanyum yüzeyinde nanoyapılı TiO2film yapısı oluşturulmuştur. Bu işlemin sonrasında, TiO2film yüzeylerine elektrolitik yöntemle Zn ve Cu kaplanmıştır. Zn ve Cu kaplanmış bu örnekler 500 oC’de 2 saat boyunca ısıl işleme tabi tutularak TiO2/ZnO ve TiO2/CuO yapılarının oluşumu sağlanmıştır. Hazırlanan örneklerin kristalin yapısı ve yüzey morfolojisi X ışını kırınım cihazı ve taramalı elektron mikroskobu ile analiz edilmiştir. Fotokatalitik performans testleri, belirli zaman aralıklarında ultraviyole ışık altında bekletilen metilen mavisi çözeltisinden alınan absorbans ölçümleri ile gerçekleştirilmiştir. Testlerin sonucunda en iyi fotokatalitik bozundurma performansına ve reaksiyon hız sabitine TiO2/ZnO numunesinin sahip olduğu anlaşılmıştır.
Türkiye Faunası İçin Yeni Bir Su Kenesi (Acari, Hydrachnidia) Kaydı: Nilotonia (Manotonia) persica Pešić & Saboori, 2006
Authors: ESEN Yunus , ERMAN Orhan 
Published: March 2019

Nilotonia(Manotonia) persicaPešić &amp; Saboori, 2006 iki dişi birey üzerinden İran’dan tanımlanmıştır. Bu türün dişileri diğer Nilotoniatürlerinden iki küçük ön plak ve bir arka plak, ilk üç bacak çiftindeki tırnaklarda iç kenarda kama şeklinde küçük bir çıkıntı, pedipalpal tibiada küçük ventral çıkıntılar, çok büyük olmayan arka eşeysel destek plağı ve oldukça narin kelisere sahip olmaları ile ayrılır. Daha sonra Pešić ve Vafaei (2009) tarafından N. (Manotonia) persica’nın erkeği İran’dan tanımlanmıştır. Erkekler ise ilk üç çift bacaktaki tırnaklarda iç kenarda küçük bir çıkıntı taşıması ile diğer türlerden ayrılır. Bu çalışmada, 2017 yılında Bingöl’ün Solhan ilçesinden bu türün iki erkek ve iki dişi bireyi toplanmıştır. Bingöl’den toplanan örnekler, N. (Manotonia)persica’nın daha önce verilen tanımına tamamen uymaktadır. Türkiye’den Manotoniaalt cinsine ait ikinci kayıt olan bu türe ait örneklerin morfolojik özellikleri, çeşitli organlara ait ölçümleri ve çizimleri verilmiştir.
Assessment of Azotobacter chroococcum’s Ability to Produce Hydrolytic Enzymes and Enhance Growth of Vicia faba
Authors: Alsalim Hutaf A. A 
Published: March 2019

A. chroococcum isolate was examined for its ability to produce the hydrolytic enzymes chitinase, pectinase, protease, and lipase, in an effort to enhance the growth of fava bean (Vicia faba). Biological experiment was conducted in pots with complete random design (CRD). The experiment includes three treatments: control (plant without treatment) (P), NPK fertilizer (plant + fertilizer) (PF), and A. chroococcum inoculum (plant + A. chroococcum) (PA). These treatments were performed with sterile and non-sterile soil, which were planted with fava beans. At the end of experiment (seven weeks from planting), length and weight of plant shoot and plant root were calculated. The results show that the isolate was able to produce chitinase, pectinase, protease, and lipase enzymes. Plant growth increased with fertilizer and A. chroococcum inoculum addition. Fertilizer treatments (PF) were the best growth indicators, with the averages of shoot length and weight, and root length and weight of 19.52 cm, 15.55 gm, 19.93 cm, and 10.52 gm respectively. The averages of these indicators in A. chroococcum treatment (PA) were 16.4 cm, 8.85 gm, 17.52 cm, and 6.88 gm respectively. The percentages of increase caused by A. chroococcum inoculum addition (PA) in contrast with control treatment (P) were 12.83% and 34.4% in plant shoot length and weight respectively, and 60.98% and 38.99% in plant root length and weight. In general, growth indicators were higher in non-sterile than sterile soil, but these increases were not significant