bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Interface Sign and Diffusion-Weighted Magnetic Resonance Imaging in Differential Diagnosis of Exophytic Renal Masses
Authors: Kulali Fatma , Kulali Safak Firat , Semiz-Oysu Aslihan , Kaya-Tuna Burcu , Bukte Yasar 
Published: April 2019

Purpose We aimed to investigate the role of interfaces of exophytic solid and cystic renal masses on magnetic resonance imaging (MRI) and the added value of diffusion-weighted imaging in differentiating benign from malignant lesions. Methods The Institutional Review Board approved this retrospective study, and informed consent was waived. A total of 265 patients (109 [41%] women and 156 [59%] men) with a mean age of 57 ± 12 (standard deviation) years were enrolled in this study. Preoperative MRI (n = 238) examinations of patients with solid or cystic renal masses and MRI (n = 27) examinations of patients with Bosniak IIF cysts without progression were reviewed. Solid/cystic pattern, interface types and apparent diffusion coefficient (ADC) values were recorded by 2 radiologists. The diagnostic performance of combining normalized ADC values with interface sign were evaluated. Results Among 265 renal lesions (109 cystic and 156 solid), all malignant lesions (n = 192) had a round interface. No malignant lesions showed an angular interface. For prediction of benignity in cystic lesions, sensitivity (82.86% vs 56.16%), negative predictive value (92.50% vs 85.71%), and accuracy (94.50% vs 87.92%) ratios of angular interface were higher compared to all (solid plus cystic) lesions. The best normalized ADC cutoff values for predicting malignancy in lesions with round interface were as follows: for all (solid plus cystic), ≤ 0.75 (AUROC = 0.804); solid, ≤ 0.6 (AUROC = 0.819); and cystic, ≤ 0.8 (AUROC = 0.936). Conclusions Angular interface can be a predictor of benignity for especially cystic renal masses. The evaluation of interface type with normalized ADC value can be an important clue in differential diagnosis especially in patients avoiding contrast.
Bondage-Discipline, Dominance-Submission and Sadomasochism (BDSM) From an Integrative Biopsychosocial Perspective: A Systematic Review
Authors: De Neef Nele , Coppens Violette , Huys Wim , Morrens Manuel 
Published: April 2019

Abstract

Introduction
BDSM (bondage and discipline, dominance and submission, and sadism and masochism) increasingly receives attention from the scientific community. Where earlier research efforts mainly focused on epidemiologic characteristics, psychological and biologic factors driving BDSM preferences have recently gained interest as well.

Aim
To bring together all the existing scientific literature on BDSM from a biopsychosocial perspective.

Methods
Based on the PRISMA guidelines, the current systematic review brings together all the existing literature on BDSM from a biopsychosocial perspective.

Main Outcome Measure
Prevalence rates of BDSM interests were investigated in the literature, as well as the associations between BDSM interests on one hand and personality traits, adverse childhood experiences, education levels, sexual orientations and biological markers on the other.

Results
Biologic factors such as gender identity, sex hormone levels, and the neurologic constitution of the brain’s pain and reward systems influence BDSM orientation. With regard to psychological factors, both personality traits (eg, higher levels of openness or extraversion) and the presence of a personality disorder have been associated with a heightened interest in BDSM, although only limited supporting evidence is available. Additionally, sensation-seeking levels and impulsivity seem to contribute, because they presumably guide one’s drive to explore new or more-intense kinks. Whereas attachment styles impact couple dynamics, they also influence willingness to explore limits in a BDSM context. Lastly, education levels impact relational and sexual dynamics.

Strengths and Limitations
The limitations of the current review reflect those of the topical scientific literature. Although the number of studies focused on all aspects of BDSM is exponentially growing, most of these are only descriptive, and very few focus on underlying driving processes.

Conclusion
From this biopsychosocial perspective, we offer a dimensional approach while integrating the factors driving the onset and evolution of BDSM interests.
A Randomized Controlled Study of Group-Administered Cognitive Behavioral Therapy for Hypersexual Disorder in Men
Authors: Hallberg Jonas , Kaldo Viktor , Arver Stefan , Dhejne Cecilia , Jokinen Jussi , Öberg Katarina Görts 
Published: April 2019

ABSTRACT

Background
Hypersexual disorder (HD) is defined as a condition in which the individual loses control over engagement in sexual behaviors, leading to distress and negative effects on key life areas. Cognitive behavioral therapy (CBT) has been proven to reduce symptoms of hypersexual behavior; however, no randomized controlled study of CBT interventions for HD has been reported previously.

Aim
To investigate the efficacy of group-administered CBT for HD.

Methods
Male participants (n = 137) diagnosed with HD, were randomized between 7 weeks of group-administered CBT (n = 70) and a waitlist control receiving the intervention after 8 weeks (n = 67). Measurements were administered at pre-, mid-, and posttreatment, with follow-up after 3 and 6 months.

Outcomes
The primary outcome was the Hypersexual Disorder: Current Assessment Scale (HD:CAS), and secondary outcomes were the Sexual Compulsivity Scale (SCS) and measures of depression (Montgomery–Åsberg Depression Rating Scale (MADRS-S), psychological distress (Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM), and treatment satisfaction (CSQ-8).

Results
A significantly greater decrease in HD symptoms and sexual compulsivity, as well as significantly greater improvements in psychiatric well-being, were found for the treatment condition compared with the waitlist. These effects remained stable at 3 and 6 months after treatment.

Clinical Implications
CBT can ameliorate HD symptoms and psychiatric distress, suggesting that the CBT program may serve as a first-line treatment in clinical settings.

Strengths & Limitations
This is the first randomized controlled study evaluating the efficacy of a CBT program in a rather large sample of HD-specific diagnosed men. The long-term treatment effects are vague due to the low response rate on follow-up measurements, and the efficacy of this program for hypersexual women remains unknown.

Conclusion
This study supports the efficacy of a group-administered CBT program as a treatment option for HD; however, future studies should include women, comprise dismantling analysis of the constituting interventions, and evaluate other treatment formats, for example, administration via the Internet.
Design of scaled model for dynamic characteristics of stiffened cylindrical shells based on equivalent similar method
Authors: Zhou L. L. , Li D. K. 
Published: April 2019

ABSTRACTScaled model test is an effective means to verify the design of a stiffened cylindrical shell. However, there is a problem of similarity distortion by use of the traditional dimensional analysis to design scaled models. In this present study, an equivalent similar method is proposed to solve the problem. The method is applied to an axial stiffened cylindrical shell, and the equivalent criteria and scaling laws satisfying the equivalent similarity of global bending mode are derived and verified by numerical examples. The results indicate that the similarity distortion caused by practical conditions for the stiffened cylindrical shell can be solved and the parameters of scaled model can be designed more freely with the proposed equivalent similar method.
Re-entry guidance method based on decoupling control variables and waypoint
Authors: Li Z. , Yang T. , Feng Z. 
Published: April 2019

ABSTRACTGenerally, earth rotating and non-spherical perturbation of the earth in re-entry motion model are simplified using the standard trajectory guidance method. The re-entry motion is also simplified to horizontal motion and vertical motion and controlled, respectively. The simplification of re-entry motion model will lead to loss of motion accuracy and location accuracy. The direct decomposition will lead to the reduction of control accuracy because the horizontal motion and the vertical motion are coupled in re-entry. To improve the standard trajectory guidance method, the standard trajectory guidance method based on decoupling control variables and waypoint is proposed in this paper. The proposed guidance method will not simplify earth rotating and non-spherical perturbation of the earth in motion equation or decompose the re-entry motion to horizontal motion and vertical motion. Trajectory waypoint is adopted to reduce the change frequency of tracking states, because tracking states change frequently if the entire standard trajectory is tracked in real time.
MAKING THE CASE FOR RELIGIOUS FREEDOM IN SECULAR SOCIETIES
Authors: Glendon Mary Ann 
Published: April 2019

This is the text of the opening keynote lecture delivered at the conference, “Is Religious Freedom under Threat?,” Christ Church, Oxford, May 23–25, 2018, convened by Oxford University's McDonald Centre for Theology, Ethics and Public Life and Emory University's Center for the Study of Law and Religion.It is truly an honor to deliver the opening lecture for this McDonald Conference titled “Is Religious Liberty under Threat?” Since it was only four years ago that I had given a talk on that subject for the Oxford Journal of Law and Religion’s Summer Academy, which built in turn upon my Harold Berman Lecture at Emory University two years before, I have had to give some serious thought to how I might avoid repeating myself. Yet when I looked back over what I said on those occasions, I wished that I had dwelt less upon the threats and more on the challenge of how to address them. What I would like to do in this lecture, therefore, is to offer some suggestions in the hope of stimulating discussion about how to make the case for religious freedom as a fundamental human right in today's increasingly secular liberal democracies.
Measuring the Implementation of Lifestyle-Integrated Functional Exercise in Primary Care for Older Adults: Results of a Feasibility Study
Authors: Gibbs Jenna C. , McArthur Caitlin , Milligan James , Clemson Lindy , Lee Linda , Boscart Veronique M. , Heckman George , Stolee Paul , Giangregorio Lora M. 
Published: April 2019

RÉSUMÉNotre étude pilote a évalué la faisabilité, l’efficacité et la mise en œuvre du programme d’exercices fonctionnels en groupe intégrés au mode de vie (Lifestyle-integrated Functional Exercise; Mi-LiFE) créé pour des personnes âgées, dans le cadre d’une pratique interprofessionnelle en soins de première ligne. Un physiothérapeute a enseigné aux participants comment intégrer des exercices de force et d’équilibre dans la routine quotidienne au cours d’une séance individuelle et de quatre séances de groupe, suivis de deux rendez-vous téléphoniques. Les résultats concernant la faisabilité incluaient le recrutement, l’adhésion et la rétention sur une période de six mois. L’activité physique (AP) (accéléromètre, IPAQ), une version courte de la batterie de tests de performance physique (SPPB) et la qualité de vie liée à la santé (EQ5D-3L) ont été évaluées au début de l’intervention et 6 mois plus tard. Des 123 personnes admissibles, 39 % ont participé à l’intervention et 61 % n’étaient pas intéressées ou non joignables. Quarante-huit participants (âge moyen ± ÉT = 81 ± 5 ans ; IMC = 28 ± 5 kg/m2 ; 60 % de femmes ; AP modérée à vigoureuse = 49 ± 87 minutes par semaine) ont pris part à cette étude. Quatre participants se sont retirés avant le début de l’intervention. Trente-deux participants (67 %) étaient présents au suivi. Le taux d’adhésion quotidien documenté dans le journal de bord était de 50 % à 6 mois, et 77 % des participants ont assisté à au moins 4 séances. Aucun changement statistiquement significatif n’a été observé dans les résultats de l’AP modérée à forte et de la SPPB. Cependant, les participants ont déclaré lors du suivi que leur force et leur équilibre dans l’AP se sont améliorés, tout comme leur qualité de vie. Le programme Mi-LiFE présente une bonne faisabilité, avec des taux de recrutement et d’assiduité acceptables. Des modifications pourraient être apportées pour améliorer la rétention et l’adhésion à l’intervention. Ces résultats renseignent sur la faisabilité de programames d’exercices pragmatiques qui pourraient être développés pour être offerts aux personnes âgées se présentant pour des soins de première ligne.
A framework to analyze knowledge management system adoption through the lens of organizational culture
Authors: Tounkara Thierno 
Published: April 2019

AbstractAlthough, the knowledge management (KM)-culture research has helped to validate the importance of cultural values for companies' KM initiatives and provided insights into some important values, it still lacks frameworks and analysis outlining how specific types of cultural values might relate to Knowledge Management system (KMS) adoption and subsequent outcomes. In this paper, we provide a three-dimensional framework to help managers articulate how culture affects their unit's ability to create, transfer, and apply knowledge through KMS use. To illustrate the application of the framework, we also present an exploratory case study we have performed in an international organization in the area of development assistance and capacity development.
Honesty and dissent: resisting the Company of St George in Tudor Norwich
Authors: McRee Ben R. 
Published: April 2019

Abstract‘Honesty and dissent’ explores strategies of political resistance in Tudor Norwich through an analysis of the city's prestigious Company of St George. Nearly a quarter of those nominated for membership during the second half of the sixteenth century failed to appear when summoned and declined to take up the livery; most eventually complied, but only after fines, threats of imprisonment and delays that could last a year or more. They pursued a strategy of passive resistance that allowed them to register objections while conforming to expectations of ‘honest’ behaviour. That underappreciated approach enabled citizens to push back against urban authorities without compromising their standing in the community.
Rare case of a superior sinus venosus atrial septal defect presenting with cyanosis
Authors: Abadeer Maher , Luceri Michael , Abraham Boban 
Published: April 2019

AbstractCyanosis in a newborn is commonly due to intracardiac shunts or duct-dependent lesions. Systemic venous anomalies are uncommon and sinus venous atrial septal defects do not usually present with cyanosis. We report the case of a 4-month-old female with persistent hypoxemia due to a right superior vena cava overriding a superior sinus venous atrial septal defect resulting in a right to left shunt.
Development of nuclear microsatellite markers in Stizophyllum (Bignoniaceae) using next-generation sequencing
Authors: Beyer Maila , Nazareno Alison Gonçalvez , Lohmann Lúcia G. 
Published: April 2019

AbstractHere we developed the first set of nuclear microsatellite markers (nSSRs) for Stizophyllum riparium (Bignoniaceae), a widespread species of Neotropical liana. Thirty-two sets of primers were isolated from a genomic dataset obtained with an Illumina HiSeq Platform, and characterized for 57 individuals of S. riparium from three populations. Nine nSSRs were polymorphic and the number of alleles ranged from eight to 29. The unbiased expected heterozygosity per locus ranged from 0.724 to 0.952 and the polymorphic information content values ranged from 0.717 to 0.944. All nine primer pairs also amplified for two closely related species (S. inaequilaterum and S. perforatum). The new set of nuclear markers will be useful for population genetics studies of Stizophyllum as a whole.
Projections of Human Exposure to Dangerous Heat in African Cities Under Multiple Socioeconomic and Climate Scenarios
Authors: Rohat Guillaume , Flacke Johannes , Dosio Alessandro , Dao Hy , van Maarseveen Martin 
Published: April 2019

AbstractHuman exposure to dangerous heat, driven by climatic and demographic changes, is increasing worldwide. Being located in hot regions and showing high rates of urban population growth, African cities appear particularly likely to face significantly increased exposure to dangerous heat in the coming decades. We combined projections of urban population under five socioeconomic scenarios—shared socioeconomic pathways—with projections of apparent temperature under three representative concentration pathways in order to explore future exposure to dangerous heat across 173 large African cities. Employing multiple shared socioeconomic pathway and representative concentration pathway combinations, we demonstrated that the aggregate exposure in African cities will increase by a multiple of 20–52, reaching 86–217 billion person‐days per year by the 2090s, depending on the scenario. The most exposed cities are located in Western and Central Africa, although several Eastern African cities showed an increase of more than 2,000 times the current level by the 2090s, due to the emergence of dangerous heat conditions combined with steady urban population growth. In most cases, we found future exposure to be predominantly driven by changes in population alone or by concurrent changes in climate and population, with the influence of changes in climate alone being minimal. We also demonstrated that shifting from a high to a low urban population growth pathway leads to a slightly greater reduction in aggregate exposure than shifting from a high to a low emissions pathway (51% vs. 48%). This emphasizes the critical role that socioeconomic development plays in shaping heat‐related health challenges in African cities.
Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors
Authors: Liu Ling , Chen Zhenyu , Zhang Xin , Li Shun , Hui Yi , Feng Hexi , Du Yanhua , Jin Guohua , Zhou Xiaohui , Zhang Xiaoqing 
Published: April 2019

AbstractIt remains largely unknown how Zika virus (ZIKV) infection causes severe microcephaly in human newborns. We examined an Asian lineage ZIKV, SZ01, which similarly infected and demonstrated comparable growth arrest and apoptotic pathological changes in human neuroprogenitors (NPCs) from forebrain dorsal, forebrain ventral as well as hindbrain and spinal cord brain organoids derived from human pluripotent stem cells. Transcriptome profiling showed common overactivated antiviral response in all regional NPCs upon ZIKV infection. ZIKV infection directly activated a subset of IFN-stimulated genes (ISGs) in human NPCs, which depended on the presence of IRF3 and NF-κB rather than IFN production and secretion, highlighting a key role of IFN-independent acute antiviral pathway underlying ZIKV infection-caused neuropathy. Our findings therefore reveal that overactivated antiviral response is detrimental rather than protective in human NPCs, and the IFN-independent acute antiviral pathway may serve as a potential target to ameliorate ZIKV infection-triggered neuropathy.
MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways
Authors: Tran Anh T. , Chapman Eric M. , Flamand Mathieu N. , Yu Bin , Krempel Samuel J. , Duchaine Thomas F. , Eroglu Matthew , Derry W. Brent 
Published: April 2019

AbstractApoptosis is a genetically programmed cell death process with profound roles in development and disease. MicroRNAs modulate the expression of many proteins and are often deregulated in human diseases, such as cancer. C. elegans germ cells undergo apoptosis in response to genotoxic stress by the combined activities of the core apoptosis and MAPK pathways, but how their signalling thresholds are buffered is an open question. Here we show mir-35–42 miRNA family play a dual role in antagonizing both NDK-1, a positive regulator of MAPK signalling, and the BH3-only pro-apoptotic protein EGL-1 to regulate the magnitude of DNA damage-induced apoptosis in the C. elegans germline. We show that while miR-35 represses EGL-1 by promoting transcript degradation, repression of NDK-1 may be through sequestration of the transcript to inhibit translation. Importantly, dramatic increase in NDK-1 expression was observed in cells about to die. In the absence of miR-35, increased NDK-1 activity enhanced MAPK signalling that lead to significant increases in germ cell death. Our findings demonstrate that NDK-1 acts upstream of (or in parallel to) EGL-1, and that miR-35 targets both egl-1 and ndk-1 to fine-tune cell killing in response to genotoxic stress.
Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis
Authors: Buskila Yossi , Kékesi Orsolya , Bellot-Saez Alba , Seah Winston , Berg Tracey , Trpceski Michael , Yerbury Justin J. , Ooi Lezanne 
Published: April 2019

AbstractAmyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND) in which humans lose motor functions due to progressive loss of motoneurons in the cortex, brainstem, and spinal cord. In patients and in animal models of MND it has been observed that there is a change in the properties of motoneurons, termed neuronal hyperexcitability, which is an exaggerated response of the neurons to a stimulus. Previous studies suggested neuronal excitability is one of the leading causes for neuronal loss, however the factors that instigate excitability in neurons over the course of disease onset and progression are not well understood, as these studies have looked mainly at embryonic or early postnatal stages (pre-symptomatic). As hyperexcitability is not a static phenomenon, the aim of this study was to assess the overall excitability of upper motoneurons during disease progression, specifically focusing on their oscillatory behavior and capabilities to fire repetitively. Our results suggest that increases in the intrinsic excitability of motoneurons are a global phenomenon of aging, however the cellular mechanisms that underlie this hyperexcitability are distinct in SOD1G93AALS mice compared with wild-type controls. The ionic mechanism driving increased excitability involves alterations of the expression levels ofHCNandKCNQchannel genes leading to a complex dynamic of H-current and M-current activation. Moreover, we show a negative correlation between the disease onset and disease progression, which correlates with a decrease in the expression level ofHCNandKCNQchannels. These findings provide a potential explanation for the increased vulnerability of motoneurons to ALS with aging.