bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting Historical Inequality Patterns: A Replication of Thomas Piketty's Wealth Concentration Estimates for the United Kingdom
Authors: Magness Phillip W. 
Published: May 2019

ObjectiveThis article utilizes a replication exercise to evaluate the reliability of the historical time series for top wealth share concentrations in the United Kingdom, as presented in Thomas Piketty's Capital in the Twenty‐First Century (2014a).MethodUsing Piketty's identified source records, an attempt is made to replicate the construction of his time series for top wealth concentrations in the U.K. These results are then compared against the series presented in Capital, and subsequent improvements by other scholars.ResultsPiketty's time series is shown to diverge substantially from its source data from the U.K., and does not appear to be replicable. In particular, Piketty's series introduces a sizable post‐1980 adjustment that suggests a substantially more rapid acceleration of wealth concentration than its source statistics reveal. Issues of reliability in the U.K. time series mirror similar problems with Piketty's wealth estimates for the United States, although their implications for historical interpretation differ in light of subsequent data.ConclusionThese findings indicate that Piketty's account of changing wealth concentrations in the United Kingdom in the 20th century is unreliable for interpreting recent patterns in the evolution of top wealth shares. An alternative interpretation of the source data is therefore offered, pointing to a century‐long L‐shaped pattern in place of Piketty's depicted U‐curve.
Impact of heat and drought stress on peroxisome proliferation in quinoa
Authors: Hinojosa Leonardo , Sanad Marwa N.M.E. , Jarvis David E. , Steel Patrick , Murphy Kevin , Smertenko Andrei 
Published: May 2019

SummaryAlthough peroxisomes play a key role in plant metabolism under both normal and stressful growth conditions, the impact of drought and heat stress on the peroxisomes remains unknown. Quinoa represents an informative system for dissecting the impact of abiotic stress on peroxisome proliferation because it is adapted to marginal environments. Here we determined the correlation of peroxisome abundance with physiological responses and yield under heat, drought and heat plus drought stresses in eight genotypes of quinoa. We found that all stresses caused a reduction in stomatal conductance and yield. Furthermore, H2O2content increased under drought and heat plus drought. Principal component analysis demonstrated that peroxisome abundance correlated positively with H2O2content in leaves and correlated negatively with yield. Pearson correlation coefficient for yield and peroxisome abundance (r = −0.59) was higher than for commonly used photosynthetic efficiency (r = 0.23), but comparable to those for classical stress indicators such as soil moisture content (r = 0.51) or stomatal conductance (r = 0.62). Our work established peroxisome abundance as a cellular sensor for measuring responses to heat and drought stress in the genetically diverse populations. As heat waves threaten agricultural productivity in arid climates, our findings will facilitate identification of genetic markers for improving yield of crops under extreme weather patterns.
The association of inpatient blood utilization and diagnosis‐related group weight: implications for risk‐adjusted benchmarking
Authors: Metcalf Ryan A. , White Sandra K. , Potter Scott , Barney Reed , Hunter Cheri , White Michael , Enniss Toby , Galaviz Charles , Reddy Santosh , Wanner Nathan , Schmidt Robert L. , Blaylock Robert 
Published: May 2019

BACKGROUNDRisk‐adjusted benchmarking could be useful to compare blood utilization between hospitals or individual groups, such as physicians, while accounting for differences in patient complexity. The aim of this study was to analyze the association of red blood cell (RBC) use and diagnosis‐related group (DRG) weights across all inpatient hospital stays to determine the suitability of using DRGs for between‐hospital risk‐adjusted benchmarking. Specific hierarchical organizational units (surgical vs. nonsurgical patients, departments, and physicians) were also evaluated.STUDY DESIGN AND METHODSWe studied blood use among all adult inpatients, and within organizational units, over 4 years (May 2014 to March 2018) at an academic center. Number of RBCs transfused, all patient refined (APR)‐DRGs, and other variables were captured over entire hospital stays. We used multilevel generalized linear modeling (zero‐inflated negative binomial) to study the relationship between RBC utilization and APR‐DRG.RESULTSA total of 97,955 hospital stays were evaluated and the median APR‐DRG weight was 1.2. The association of RBCs transfused and APR‐DRG weight was statistically significant at all hierarchical levels (incidence rate ratio = 1.22; p < 0.001). The impact of APR‐DRG on blood use, measured by the incidence rate ratio, demonstrated an association at the all‐patient and surgical levels, at several department and physician levels, but not at the medical patient level. The relationship between RBCs transfused and APR‐DRG varied across organizational units.CONCLUSIONNumber of RBCs transfused was associated with APR‐DRG weight at multiple hierarchical levels and could be used for risk‐adjusted benchmarking in those contexts. The relationship between RBC use and APR‐DRG varied across organizational units.
A Coupled Thermomechanical Modeling Method for Predicting Grinding Residual Stress Based on Randomly Distributed Abrasive Grains
Authors: Nie Zhenguo , Wang Gang , Wang Liping , Rong Yiming (Kevin) 
Published: May 2019

Abstract
In this research, we propose a coupled thermomechanical modeling method for predicting grinding residual stress based on randomly distributed grains. In order to deal with the problem that the nominal grinding force is too small to generate the plastic deformation, we hold the opinion that grinding residual stress is totally derived from three factors: thermal stress, the nominal grinding force (pressure) over the entire grinding zone, and the equivalent plowing force just under the bottom of the abrasive wheel. Finite element model (FEM) simulation of the single-grain grinding (SGG) is conducted to obtain the critical plowing depth and the SGG force at an arbitrary cutting depth. Based on the randomly distributed abrasive grains, the equivalent grinding heat source model, the equivalent SGG plowing force model, and the equivalent nominal pressure model are all established. A 2D coupled thermomechanical model is established to simulate the grinding process for temperature fields and grinding residual stress fields. In addition, verification tests are conducted to validate the model. It turns out that the coupled model can accurately predict the multiphysical fields on both temperature and residual stress. Based on the simulation results of the model, the generation mechanism of grinding residual stress is quantitatively studied. This research provides a promising pathway to residual stress control of grinding.
Computational Fluid Dynamics Modeling and Experimental Validation of the Thermofluidic Performance of Climatic Chambers
Authors: Silva R. , Brett M. , Ferreira Almerindo D. , Serra C. , Jesus T. , Fino M. , Tadeu A. , Mendes J. , Raújo J. , Santos R. 
Published: May 2019

Abstract
Climatic chambers are of great importance in research and development to conduct tests of components in closed environmentally controlled conditions. The growing demand from the industry to fulfill stricter international standards creates the necessity to ensure that the thermofluidic behavior of climatic chambers guarantees high-quality consistency in their interior domain. At present, scientific research on climatic chambers available in the literature is scarce and is mostly based on lumped modeling, hence not addressing the heterogeneities that arise in the interior of the chamber. In this work, an in-depth 3D model of the velocity and temperature fields that develops in the interior of climatic chambers was developed in computer fluid dynamics (CFD) and validated with the experimental data from a new prototype. The key objective of this research was to establish a validated framework for model-based design optimization of climatic chambers. The proposed model showed good agreement with the experimental data with a difference of 0.6 m/s and 9.65 °C in the velocity and temperature fields, respectively, thus validating its applicability to perform model-based design optimization of climatic chambers.
An Experimental Study on Combustion and Performance of a Liquefied
Natural Gas–Diesel Dual-Fuel Engine With Different Pilot Diesel
Quantities
Authors: Song Jiantong , Wang Guna 
Published: May 2019

Abstract
The pilot diesel quantity (mpilot) has an impact on the liqueified nitrogen gas (LNG)-diesel dual-fuel engine, but it is very difficult for a dual-fuel engine with the traditional injection system to adjust mpilot to meet various operating conditions in practice. In recent years, with great progress in common rail diesel injection technology, mpilot can be adjusted accurately by the electronic control system, which is an advantage for operation with the diesel–LNG dual-fuel. In order to optimize mpilot of the diesel–LNG dual-fuel engine, the combustion and performance of a dual-fuel engine with the mpilot of 5.05 mg/cyc, 5.20 mg/cyc, 5.69 mg/cyc, 6.31 mg/cyc and 6.91 mg/cyc under 50% load at speed of 1600 r/min were analyzed. Experimental results show that, with an increase in mpilot, the maximum in-cylinder pressure, rate of pressure rise, and heat release rate of dual-fuel obviously increase, the crank angles of the maximum value move forward, and the combustion duration becomes shorter. The mean value of peak in-cylinder pressure (pmax) increases obviously while the standard deviation of it decreases, and the distribution of that focuses. The mean value of the crank angle corresponding to pmax pressure decreases except for the mpilot of 5.05 mg/cyc, while the standard deviation of that gradually decreases, the distribution of it focuses and moves forward. The brake power increases while the brake-specific fuel consumption (BSFC) decreases, the CO and HC decrease, while the CO2, NOx, and smoke density emissions increase.
Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review
Authors: Booth Alison , Ingoe Helen Margaret Ann , Northgraves Matthew , Coleman Elizabeth , Harden Melissa , Kassam Jamila , Kwok Iris , Hilton Catherine , Bates Peter , McDaid Catriona 
Published: May 2019

ObjectivesTo undertake a systematic review of the evidence base for the effectiveness of surgical fixation of lateral compression (LC-1) fragility fractures of the pelvis compared with non-surgical approaches.SearchesMEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and two international trials registers were searched up to January 2017 (MEDLINE to February 2019) for studies of internal or external fixation of fragility fractures of the pelvis.ParticipantsPatients with lateral compression pelvic fractures, sustained as the result of a low-energy mechanism, defined as a fall from standing height or less.InterventionsSurgery using either external or internal fixation devices. Conservative non-surgical treatment was the defined comparator.Outcome measuresOutcomes of interest were patient mobility and function, pain, quality of life, fracture union, mortality, hospital length of stay and complications (additional operative procedures, number and type of adverse events and serious adverse events).Quality assessment and synthesisThe Joanna Briggs Institute Checklist for Case Series was used to assess the included studies. Results were presented in a narrative synthesis.ResultsOf 3421 records identified, four retrospective case series met the inclusion criteria. Fixation types were not consistent between studies or within studies and most patients had more than one type of pelvic fixation. Where reported, mobility and function improved post-surgery, and a reduction in pain was recorded. Length of hospital stay ranged from 4 days to 54 days for surgical fixation of any type. Reported complications and adverse outcomes included: infections, implant loosening, pneumonia and thrombosis. Use of analgesia was not reported.ConclusionsThere is insufficient evidence to support guidance on the most effective treatment for patients who fail to mobilise after sustaining an LC-1 fragility fracture.Trial registration numberCRD42017055872.
Acute Cuff Tear Repair Trial (ACCURATE): protocol for a multicentre, randomised, placebo-controlled trial on the efficacy of arthroscopic rotator cuff repair
Authors: Ryösä Anssi , Kukkonen Juha , Björnsson Hallgren Hanna Cecilia , Moosmayer Stefan , Holmgren Teresa , Ranebo Mats , Bøe Berte , Äärimaa Ville 
Published: May 2019

IntroductionRotator cuff tear is a very common and disabling condition that can be related to acute trauma. Rotator cuff tear surgery is a well-established form of treatment in acute rotator cuff tears. Despite its widespread use and almost a gold standard position, the efficacy of an arthroscopic rotator cuff repair is still unknown. The objective of this trial is to investigate the difference in outcome between arthroscopic rotator cuff repair and inspection of the shoulder joint defined as placebo surgery in patients 45–70 years of age with an acute rotator tear related to trauma.Methods and analysisAcute Cuff Tear Repair Trial (ACCURATE) is a randomised, placebo-controlled, multicentre efficacy trial with sample size of 180 patients. Concealed allocation is done in 1:1 ratio. The randomisation is stratified according to participating hospital, gender and baseline Western Ontario Rotator Cuff Index (WORC). Both groups receive the same standardised postoperative treatment and physiotherapy. The primary outcome measure is the change in WORC score from baseline to 2-year follow-up. Secondary outcome measures include Constant-Murley Score, the Numerical Rating Scale for pain, subjective patient satisfaction and the health-related quality of life instrument 15 dimensions (15D). Patients and outcome assessors are blinded from the allocated intervention. The primary analysis of results will be conducted according to intention-to-treat analysis.Ethics and disseminationThe study protocol for this clinical trial has been approved by the Ethics Committee of the Hospital District of Southwest Finland and Regional Ethics Committee in Linköping Sweden and Regional Committees for Medical and Health Research Ethics South East in Norway. Every recruiting centre will apply local research approvals. The results of this study will be submitted for publication in peer-reviewed journals.Trial registration numberNCT02885714; Pre-results.
Sociodemographic factors in relation to hypertension prevalence, awareness, treatment and control in a multi-ethnic Asian population: a cross-sectional study
Authors: Liew Seaw Jia , Lee John Tayu , Tan Chuen Seng , Koh Choon Huat Gerald , Van Dam Rob , Müller-Riemenschneider Falk 
Published: May 2019

ObjectivesLiterature suggested that multi-ethnic Western populations experienced differential hypertension outcomes, but evidence is limited in Asia. This study was aimed to determine sociodemographic correlates of hypertension and its awareness, treatment and control among a multi-ethnic Asian population living in Singapore.SettingWe used cross-sectional data of participants from the Multi-Ethnic Cohort (MEC) (n=14 530) recruited in Singapore between 2004 and 2010.ParticipantsParticipants who completed questionnaire and attended health examination, without cardiovascular diseases, cancer, stroke, renal failure, asthma and mental illnesses were included in the study. Multivariable logistic regression models were used to determine sociodemographics factors associated with hypertension, unawareness of having hypertension, untreated and uncontrolled hypertension.ResultsAmong 10 215 participants (47.2% Chinese, 26.0% Malay and 26.8% Indian), hypertension prevalence was estimated to be 31.1%. Older age, Malay ethnicity, male, lower educational level and being homemaker or retired/unemployed were factors significantly associated with hypertension. Stratified analysis suggested that age and education were consistently associated with hypertension across all ethnic groups. The proportions of being unaware, untreated and uncontrolled were 49.0%, 25.2% and 62.4%, respectively. Ethnicity and younger age were associated with unawareness; younger age, male and lower educational level were associated with untreated hypertension and older age was associated with uncontrolled hypertension.ConclusionsIn this study, ethnic differences in relation to hypertension were associated with sociodemographic variability in ethnic groups. Age and educational level were consistent correlates of hypertension in all ethnic groups. Unawareness and uncontrolled hypertension were common in this Asian population and associated with sociodemographic factors. More targeted strategies may be required to overcome the observed disparities.
Sarcome-13/OS2016 trial protocol: a multicentre, randomised, open-label, phase II trial of mifamurtide combined with postoperative chemotherapy for patients with newly diagnosed high-risk osteosarcoma
Authors: Brard Caroline , Piperno-Neumann Sophie , Delaye Jessy , Brugières Laurence , Hampson Lisa V , Le Teuff Gwénaël , Le Deley Marie-Cécile , Gaspar Nathalie 
Published: May 2019

IntroductionThe controversial results on the mifamurtide efficacy associated with chemotherapy, issued from the American INT-0133-study, in localised osteosarcomas, and the underpowered analysis performed separately in metastatic patients, should be clarified to homogenise international use of this promising drug. The European Commission has granted a marketing authorisation to mifamurtide combined with postoperative chemotherapy in localised osteosarcomas but not in metastatic patients, while the Food and Drug Administration (FDA) has denied this authorisation.Methods and analysisSarcome-13/OS2016 trial is a multicentre randomised open-label phase II trial evaluating the survival benefit of mifamurtide administered during 36 weeks in combination with postoperative chemotherapy versus chemotherapy alone, in patients >2 and ≤50 years with newly diagnosed high-risk localised or metastatic osteosarcoma. The main objective is to evaluate the impact on event-free survival (EFS) of mifamurtide on intention-to-treat population. The secondary objectives are to evaluate the impact of mifamurtide on overall survival, to evaluate the feasibility and toxicity of the planned treatment, to correlate biology/immunology with the mifamurtide efficacy/toxicity. With a total of 126 enrolled patients and 51 events, the power is 80% if mifamurtide is associated with an 18% improvement of the 3-year EFS (52%vs70%, equivalent to an HR=0.55), with a one-sided logrank test alpha=10%. As relevant historical data are available (aggregate treatment effect from the INT-0133 trial and individual data from the control group of the Sarcome-09/OS2006 trial), a Bayesian analysis is also planned.Ethics and disseminationThis study was approved by the ‘Comité de Protection des Personnes Ile de France I’ (12/06/2018), complies with the Declaration of Helsinki and French laws and regulations, and follows the International Conference on Harmonisation E6 Guideline for Good Clinical Practice. The trial results, even if they are inconclusive, as well as biological ancillary studies will be presented at appropriate international congresses and published in international peer-review journals.Trial registration numberEudraCT 2017-001165-24,NCT03643133
Adverse events following immunisation with four-component meningococcal serogroup B vaccine (4CMenB): interaction with co-administration of routine infant vaccines and risk of recurrence in European randomised controlled trials
Authors: Zafack Joseline Guetsop , Bureau Alexandre , Skowronski Danuta M , De Serres Gaston 
Published: May 2019

Objectives(1) To assess if co-administration of four-component meningococcal serogroup B vaccine (4CMenB) and other routine vaccines caused an interaction increasing the risk and/or severity of adverse events following immunisation (AEFI) compared with administration at separate visits and (2) to estimate the risk of AEFI recurrence.DesignRisk-interval designSettingThree randomised controlled trials conducted in Europe.ParticipantsA total of 5026 healthy 2-month-old to 15-month-old infants.Interventions4CMenB and routine vaccines (hexavalent combined diphtheria-tetanus-acellular pertussis-inactivated polio-Haemophilus influenzae type b-hepatitis B vaccine+seven-valent pneumococcal conjugate vaccine or measles-mumps-rubella-varicella vaccine) administered concomitantly or separately 1 month apart, in regular (2, 4, 6 and 12 months), accelerated (2, 3, 4 and 12 months) or delayed (two doses of 4CMenB at ≥12 months of age) schedules.Outcome measuresPrimary: Fever (≥38°C) during the first 48 hours post immunisation. Secondary: crying, change in eating habits, diarrhoea, irritability and tenderness at the 4CMenB injection site.ResultsCompared with separate administration, concomitant administration decreased the overall incidence of fever (≥38°C), 86% versus 75%, and other systemic AEFIs but increased the incidence of 4CMenB injection site tenderness, 55% versus 66%, moderate/severe fevers (≥39°C), 13% versus 18%, and long-lasting (>1 day) fevers, 23% versus 33%. Co-administration reduced AEFI risk by 4%–49% with the greatest impact among infants with prior AEFI(s). Fever recurrence risk was proportional to the number of prior fever events: 79% at dose 2 with one prior episode; 44% and 74% at dose 3 with one and two prior episodes, respectively; and 29%, 45% and 60% at dose 4 with one, two and three prior episodes, respectively. Severity was not increased at recurrence and a similar pattern of recurrence risk proportional to the number of prior events was observed for other AEFIs.ConclusionsThe cumulative risk of AEFI is reduced with concomitant versus separate administration of 4CMenB and routine infant vaccines. Infants with a prior AEFI are at higher risk of the same AEFI at subsequent immunisations, but severity with recurrence is usually not increased.Trials registration numberNCT00657709,NCT00847145,NCT00721396andNCT02712177; Pre-results.