bluuebunny/crossref_metadata_2025_split huggingface dataset:
Centennial-Scale Temperature Change in Last Millennium Simulations and Proxy-Based Reconstructions
Authors: Ljungqvist Fredrik Charpentier , Zhang Qiong , Brattström Gudrun , Krusic Paul J. , Seim Andrea , Li Qiang , Zhang Qiang , Moberg Anders 
Published: February 2019

AbstractSystematic comparisons of proxy-based reconstructions and climate model simulations of past millennium temperature variability offer insights into climate sensitivity and feedback mechanisms, besides allowing model evaluation independently from the period covered by instrumental data. Such simulation–reconstruction comparisons can help to distinguish more skillful models from less skillful ones, which may subsequently help to develop more reliable future projections. This study evaluates the low-frequency simulation–reconstruction agreement within the past millennium through assessing the amplitude of temperature change between the Medieval Climate Anomaly (here, 950–1250 CE) and the Little Ice Age (here, 1450–1850 CE) in PMIP3 model simulations compared to proxy-based local and continental-scale reconstructions. The simulations consistently show a smaller temperature change than the reconstructions for most regions in the Northern Hemisphere, but not in the Southern Hemisphere, as well as a partly different spatial pattern. A cost function analysis assesses how well the various simulations agree with reconstructions. Disregarding spatial correlation, significant differences are seen in the agreement with the local temperature reconstructions between groups of models, but insignificant differences are noted when compared to continental-scale reconstructions. This result points toward a limited possibility to “rank” models by means of their low-frequency temperature variability alone. The systematically lower amplitude of simulated versus reconstructed temperature change indicates either too-small simulated internal variability or that the analyzed models lack some critical forcing or have missing or too-weak feedback mechanisms. We hypothesize that too-cold initial ocean conditions in the models—in combination with too-weak internal variability and slow feedbacks over longer time scales—could account for much of the simulation–reconstruction disagreement.
The Strength of Low-Cloud Feedbacks and Tropical Climate: A CESM Sensitivity Study
Authors: Erfani Ehsan , Burls Natalie J. 
Published: February 2019

Abstract
Variability in the strength of low-cloud feedbacks across climate models is the primary contributor to the spread in their estimates of equilibrium climate sensitivity (ECS). This raises the question: What are the regional implications for key features of tropical climate of globally weak versus strong low-cloud feedbacks in response to greenhouse gas–induced warming? To address this question and formalize our understanding of cloud controls on tropical climate, we perform a suite of idealized fully coupled and slab-ocean climate simulations across which we systematically scale the strength of the low-cloud-cover feedback under abrupt 2 × CO2 forcing within a single model, thereby isolating the impact of low-cloud feedback strength. The feedback strength is varied by modifying the stratus cloud fraction so that it is a function of not only local conditions but also global temperature in a series of abrupt 2 × CO2 sensitivity experiments. The unperturbed decrease in low cloud cover (LCC) under 2 × CO2 is greatest in the mid- and high-latitude oceans, and the subtropical eastern Pacific and Atlantic, a pattern that is magnified as the feedback strength is scaled. Consequently, sea surface temperature (SST) increases more in these regions as well as the Pacific cold tongue. As the strength of the low-cloud feedback increases this results in not only increased ECS, but also an enhanced reduction of the large-scale zonal and meridional SST gradients (structural climate sensitivity), with implications for the atmospheric Hadley and Walker circulations, as well as the hydrological cycle. The relevance of our results to simulating past warm climate is also discussed.
Understanding Biases in Simulating the Diurnal Cycle of Convection over the Western Coast of Sumatra: Comparison with Pre-YMC Observation Campaign
Authors: Dipankar Anurag , Webster Stuart , Huang Xiang-Yu , Doan Van Quang 
Published: February 2019

Abstract
Biases in simulating the diurnal cycle of convection near the western coast of the island of Sumatra have been investigated using the data from the pilot field campaign of the Years of the Maritime Continent (pre-YMC). The campaign was carried out at a sea [Research Vessel (R/V) Mirai] and a land (Bengkulu, Sumatra) site. Simulations are performed using a tropical configuration of the Met Office model at a grid resolution of 1.5 km in a limited-area mode. The focus of this study is to understand how biases in the input conditions from ECMWF high-resolution deterministic forecast affect the diurnal cycle. Modeled precipitation is found to be delayed and weak, with cold SST bias in the model as the key contributing factor affecting convection at both sites. Colder SST causes a delay in the trigger of convection at Bengkulu by delaying the onset of the local land breeze, which in turn delays the local convergence. The cold outflow from precipitation over the adjacent mountain is also found to be delayed in the model, contributing to the total delay. This delay in the evening convection at Bengkulu is shown to directly affect the timing of nighttime convection at Mirai. Weaker convection at Bengkulu is argued to be due to lower-tropospheric dry humidity bias in the model initial condition. Convection at Mirai is shown to be caused by the convergence of the cold outflow from Bengkulu with the prevailing landward wind over the sea. Both thermodynamic and dynamic conditions near the cold outflow front are found to be less favorable for intense convection in the simulation, the reason for which is argued to be a combination of the cold SST bias and a weaker cold outflow.
Does Repeated Exposure to Critical Situations in a Screen-Based Simulation Improve the Self-Assessment of Non-Technical Skills in Postpartum Hemorrhage Management?
Authors: Barré Jessy , Michelet Daphné , Job Anais , Truchot Jennifer , Cabon Philippe , Delgoulet Catherine , Tesnière Antoine 
Published: February 2019

Background. Postpartum hemorrhage (PPH) is the leading cause of maternal death in the world. Non-technical skills (e.g. communication) are now recognized as a contributing factor to medical safety. In the field of simulation, screen-based simulations are currently very popular with computer/technological development. This study evaluates a screen-based simulation device, PerinatSims, developed to improve technical and non-technical skills in PPH situation. This experiment hypothesized that exposure and repetition of training with PerinatSims would improve the self-assessment of non-technical skills, and therefore increase the ability to manage PPH. Methods. The primary endpoint was a self-assessment of non-technical skills during simulation session of PPH on a digital simulator. Twenty French midwives performed three of nine 25 minutes sessions of PPH screen-based simulation. Four self-assessment questionnaires were administered at the end of each simulation session: a leadership/team working questionnaire (BAT), a negative feelings/emotional questionnaire (DASS-21), a Flow questionnaire and a mental load questionnaire (NASA-TLX). Results between sessions were compared using a repeated measures ANOVA followed by a Bonferroni post hoc test. Results. The study showed a positive evolution during the three screen-based simulation sessions: an increase of leadership and team working self-assessment, an increase of Flow sense, and a decrease of negative emotions (anxiety and depression in the DASS-21 score). Significant decrease of stress was found only between the second and the third sessions, and significant differences in the NASA-TLX were observed only in two dimensions, Performance and Frustration. Conclusion. A repeated exposure to PPH situations with a screen-based simulation tool improved the midwives’ self-assessment, especially for leadership, team working, emotion management and Flow sense. Furthermore, midwives had a very positive feedback on the device. They highlighted the desire to use PerinatSims more often to be trained to PPH management, for technical as well as non-technical skills.
Clinical Interventions to Reduce Suicidal Behaviors in Hispanic Adolescents: A Scoping Review
Authors: Villarreal-Otálora Tatiana , Jennings Porter , Mowbray Orion 
Published: February 2019

Purpose: A significant portion of adolescents who engage in suicidal behaviors are of Hispanic origin, yet little is known regarding interventions to reduce suicidal behaviors among Hispanic adolescents. Through a culturally responsive framework, this study describes and systematically maps the existing research on interventions to treat suicidality among Hispanic adolescents. Method: Using Arksey and O’Malley’s scoping review methodology, nine publications were selected for review from available peer-reviewed literature published between 2013 and 2017. Results: Eight interventions were identified. All were published in nonsocial work journals. Interventions were implemented in either mental health or after-school community settings and included a family focus. Discussion: The analysis revealed three themes: (1) There is scant research on this topic, (2) there is a void of social work scholarly literature regarding this issue, and (3) identified interventions generally include culturally responsive factors. Implications for social work research and practice are discussed.
Large-scale opacification of a hydrophilic/hydrophobic intraocular lens
Authors: Costa José F , Bompastor-Ramos Paula , Marques Marco , Henriques Jorge , Póvoa João , Lobo Conceição , Alió Jorge L , Werner Liliana , Murta Joaquim 
Published: February 2019

Purpose:To determine the prevalence and risk factors related to the opacification of the LS-502-1 intraocular lens.Methods:Cross-sectional study including patients submitted to cataract surgery between January 2010 and March 2012, with implantation of the LS-502-1 intraocular lens. Past medical history was registered and a complete ophthalmologic evaluation, that included best-corrected visual acuity, slit-lamp examination and fundoscopy, was performed. Anterior segment photographs were taken whenever intraocular lens opacification was present.Results:One hundred and sixty-nine eyes of 154 patients were included, mean age 78.5 ± 7.9 years. The average follow-up after intraocular lens implantation was 65.6 ± 10.0 months. Intraocular lens opacification was seen in 53.3% (n = 90) and presented as one of four different patterns: peripheral (15.6%, n = 14), central (4.4%, n = 4), diffuse (71.1%, n = 64) and superficial white deposits (8.9%, n = 8). There was no statistically significant association with systemic or ophthalmic conditions. In patients with bilateral implantation, intraocular lens opacification in one eye was significantly related to intraocular lens opacification in the fellow eye. A significant variability in opacification was found across intraocular lens serial numbers: the odds ratio for opacification in intraocular lens with serial number beginning with 200003 was 6.0 when comparing with the remaining lenses.Conclusion:The opacification prevalence of the LS-502-1 intraocular lens was 53.3%, which is the highest ever described for any intraocular lens model. Our results suggest that this occurrence is secondary to an interaction between unknown patient variables and problems related to intraocular lens manufacturing and storage procedures.
Breast Cancer in Very Young Patients in a Spanish Cohort: Age as an Independent Bad Prognostic Indicator
Authors: Martínez María Teresa , Oltra Sara S , Peña-Chilet María , Alonso Elisa , Hernando Cristina , Burgues Octavio , Chirivella Isabel , Bermejo Begoña , Lluch Ana , Ribas Gloria 
Published: February 2019

Purpose: Breast cancer (BC) in very young women (BCVY) is more aggressive than in older women. The purpose of this study was to evaluate the relevance of a range of clinico-pathological factors in the prognosis of BCVY patients. Methods: We retrospectively analyzed 258 patients diagnosed with BCVY at our hospital from 1998 to 2014; the control group comprised 101 older patients with BC. We correlated clinicopathological factors, treatments, relapse and exitus with age and with previously published miRNA expression data. Results: We identified some significant differences in risk factors between BCVY and older patients. The age at menarche, number of pregnancies, and age at first pregnancy were lower in the BCVY group and had a greater probability of recurrence and death in all cases. Lymph node-positive patients in the BCVY group are associated with a worse prognosis ( P  = .02), an immunohistochemical HER2+ subtype, and disease relapse ( P  = .03). Moreover, there was a shorter time between diagnosis and first relapse in BCVY patients compared with controls, and they were more likely to die from the disease ( P  = .002). Finally, from our panel of miRNAs deregulated in BC, reduced miR-30c expression was associated with more aggressive BC in very young patients, lower overall survival, and with axillary lymph node metastases. Conclusions: Patient age and axillary lymph node status post-surgery are independent and significant predictors of distant disease-free survival, local recurrence-free survival, and overall survival. The HER2+ subtype and lower miR-30c expression are related to poor prognosis in lymph node-positive young BC patients.
Effectiveness of telemonitoring-enhanced support over structured telephone support in reducing heart failure-related healthcare utilization in a multi-ethnic Asian setting
Authors: Leng Chow Wai , Aung Chaw Yu K , Tong Shao Chuen , Goh Geraldine SL , Lee Sheldon , MacDonald Michael R , Ng Angela NK , Cao Yan , Ahmad Atikah E , Yap Mei Foon , Leong Gerard , Bruege Armin , Tesanovic Aleksandra , Riistama Jarno , Pang Sze Yunn , Erazo Fernando 
Published: February 2019

Aims Our study aimed to compare the effectiveness of telemonitoring over structured telephone support in reducing heart failure-related healthcare utilization. Methods This was a non-randomised controlled study comparing 150 recently discharged heart failure patients enrolled into telemonitoring and 55 patients who only received structured telephone support after rejecting telemonitoring. Patient activation, knowledge and self-management levels were measured at baseline and the one year upon programme completion using the Patient Activation Measure, the Dutch Heart Failure Knowledge Scale and the Self-Care of Heart Failure Index respectively. Differences in heart failure-related and all-cause hospitalization rates, total bed days and mortality rates at 180 days and at one year, knowledge and self-management scores and total cost of care between groups at one year were analysed. Results Average age of telemonitoring was 57.9 years and 63.9 years for structured telephone support. Significant difference in adjusted 180-day all-cause bed days (telemonitoring: five days versus structured telephone support: 9.8 days), heart failure-related bed days (telemonitoring: 1.2 days versus structured telephone support: six days) and adjusted one-year heart failure-related bed days (telemonitoring: 2.2 days versus structured telephone support: 6.6 days) were observed. Telemonitoring was associated with reduced all-cause one-year mortality (hazard ratio 0.32, p = 0.02). Estimated mean maintenance and confidence scores were significantly higher in the telemonitoring group at one year. No differences in all-cause and HF-related readmission rates and knowledge levels were observed. The one-year total cost of care was predicted to be Singapore dollars (SG$) 2774.4 lower ( p = 0.07) in telemonitoring. Conclusion In conclusion, telemonitoring was associated with lower all-cause and heart failure-related total bed days at 180 days, lower heart failure-related total bed days and total cost of care at one year as compared with structured telephone support.
Prioritarianism: A response to critics
Authors: Adler Matthew D , Holtug Nils 
Published: February 2019

Prioritarianism is a moral view that ranks outcomes according to the sum of a strictly increasing and strictly concave transformation of individual well-being. Prioritarianism is ‘welfarist’ (namely, it satisfies axioms of Pareto Indifference, Strong Pareto, and Anonymity) as well as satisfying three further axioms: Pigou–Dalton (formalizing the property of giving greater weight to those who are worse off), Separability, and Continuity. Philosophical discussion of prioritarianism was galvanized by Derek Parfit’s 1991 Lindley Lecture. Since then, and notwithstanding Parfit’s support, a variety of criticisms of prioritarianism have been advanced: by utilitarians (such as John Broome and Hilary Greaves), egalitarians (such as Lara Buchak; Michael Otsuka and Alex Voorhoeve; Ingmar Persson; and Larry Temkin), and sufficientists (Roger Crisp). In previous work, we have each endorsed prioritarianism. This article sets forth a renewed defense, in the light of the accumulated criticisms. We clarify the concept of a prioritarian moral view (here addressing work by David McCarthy), discuss the application of prioritarianism under uncertainty (herein of ‘ex post’ and ‘ex ante’ prioritarianism), distinguish between person-affecting and impersonal justifications, and provide a person-affecting case for prioritarianism. We then describe the various challenges mounted against prioritarianism – utilitarian, egalitarian, and sufficientist – and seek to counter each of them.
Stigma and Dissatisfaction of Health Care Personnel in HIV Response in Iran: A Qualitative Study
Authors: Rasoolinejad Mehrnaz , Abedinia Nasrin , Noorbala Ahmad Ali , Mohraz Minoo , McMillan Ian , Moradmand Banafsheh , Gilkison John Henry 
Published: February 2019

Background and Aims: With regard to the disease pandemics of HIV/AIDS, it is clear that there is need for prevention, treatment, care, and support of HIV positive patients in the health care system. In order to achieve these goals, job satisfaction should be a priority for health care staff. This study examined the problems of health care personnel and the behavior of patients undergoing HIV/AIDS counseling at Imam Khomeini Hospital in Tehran, Iran. Methods: Interviews were conducted individually with 5 health care personnel who participated in this study. Participants had 30 to 45 minutes each per session at the clinic, during which they were able to discuss the problems they faced in their careers. All conversations were officially recorded. Results: The most common problems mentioned by these health care workers included the lack of safety and standardization of work conditions, the lack of appropriate equipment, limited space, high numbers of patients, low staffing levels and financial and morale problems compounded by the lack of support by hospital authorities. Conclusion: The authorities need to allocate more funds to provide facilities and appropriate working conditions for health care staff in order to increase job satisfaction and enable staff to provide the best services and care to HIV positive patients.
Viral, immunologic, and clinical features of primary effusion lymphoma
Authors: Lurain Kathryn , Polizzotto Mark N. , Aleman Karen , Bhutani Manisha , Wyvill Kathleen M. , Gonçalves Priscila H. , Ramaswami Ramya , Marshall Vickie Ann , Miley Wendell , Steinberg Seth M. , Little Richard F. , Wilson Wyndham , Filie Armando C. , Pittaluga Stefania , Jaffe Elaine S. , Whitby Denise , Yarchoan Robert , Uldrick Thomas S. 
Published: February 2019

AbstractPrimary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and ∼80% of tumors are coinfected with Epstein-Barr virus (EBV). A better understanding of how KSHV-related immune dysregulation contributes to the natural history of PEL will improve outcomes. Twenty patients with PEL diagnosed between 2000 and 2013, including 19 treated with modified infusional etoposide, vincristine, and doxorubicin with cyclophosphamide and prednisone (EPOCH), were identified. We compared their clinical, virologic, and immunologic features vs 20 patients with HIV-associated diffuse large B-cell lymphoma and 19 patients with symptomatic interleukin (IL)-6 related KSHV-associated multicentric Castleman disease. Survival analyses of treated patients with PEL were then performed to identify prognostic factors and cancer-specific mortality. Compared with HIV-associated diffuse large B-cell lymphoma, PEL was associated with significant hypoalbuminemia (P &lt; .0027), thrombocytopenia (P = .0045), and elevated IL-10 levels (P &lt; .0001). There were no significant differences in these parameters between PEL and KSHV-associated multicentric Castleman disease. Median overall survival in treated patients with PEL was 22 months, with a plateau in survival noted after 2 years. Three-year cancer-specific survival was 47%. EBV-positive tumor status was associated with improved survival (hazard ratio, 0.27; P = .038), and elevated IL-6 level was associated with inferior survival (hazard ratio, 6.1; P = .024). Our analysis shows that IL-6 and IL-10 levels contribute to the natural history of PEL. Inflammatory cytokines and tumor EBV status are the strongest prognostic factors. Pathogenesis-directed first-line regimens are needed to improve overall survival in PEL.
Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation–induced senescence
Authors: Shudofsky Abigail M. Druck , Giam Chou-Zen 
Published: February 2019

Abstract
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL). The HTLV-1 viral trans-activator/oncoprotein Tax is a major driver of ATL, yet it induces rapid p21Cip1/Waf1 (p21)- and p27Kip1-mediated cellular senescence through constitutive activation (hyperactivation) of NF-κB. Although constitutive NF-κB activation is a common feature of T/B-cell leukemia/lymphoma, including ATL, it is not known how ATL cells maintain chronic NF-κB activation without undergoing senescence. Here, we demonstrate that, in contrast to HTLV-1− T-cell lines, ATL cell lines no longer undergo Tax-induced senescence. Although Tax+ and Tax− ATL cell lines showed signatures of constitutive NF-κB activation, their ability to progress through the cell cycle was unaffected. In some cases, ATL cell lines continued to proliferate despite significant upregulation of p21; additionally, many cell lines displayed altered expression of G1 and G1/S cyclins, particularly overexpression of cyclin D2. We propose that, during the course of ATL development, leukemia cells acquire genetic/epigenetic changes that can mitigate the senescence response triggered by NF-κB hyperactivation. Restoring the NF-κB–induced senescence response would likely help to control the development and progression of ATL and similar lymphoid malignancies.