bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined approach of perioperative antithromboembolic management in abdominal and thyroid surgery
Authors: Beyshenaliev Alymkadyr , Zhumagulov Nurgazy , Atabaev Taalaibek , Nyshanov Begmamat 
Published: March 2019

Objective: Venous thromboembolism (VTE) in the form of either pulmonary embolism (PE) or deep vein thrombosis (DVT) complicates major surgery not infrequently. We analyzed in this study superiority of combined approach of thromboprophylaxis compared to conventional nonpharmacological preventive sets.

Methods: We prescribed both pharmacological and non-pharmacological thromboprophylactic interventions for patients encountered thoracoabdominal surgery from 2013 to 2018 at clinic named after I.K.Akhunbaev of Bishkek city and Interregional United Clinical Hospital of Osh city. Demographic characteristics and clinical examination data were evaluated. Thrombogenic risk for every patient was assessed. Screening for detection of VTE was conducted in early postoperative period.

Results: Two hundred forty-six candidates of abdominal and thyroid surgery were divided into 2 groups according to patient preference for prevention modality: combined and non-pharmacological. In the early postoperative period, venous thrombosis of the lower extremities developed in 17 patients non-pharmacological group and 8 patients of combined interventions (p&amp;lt;0.05).

Conclusion: Timely commenced, combined non-drug and pharmacological preventive sets for thromboembolic complications during major surgery decreases the incidence of venous thromboembolic complications.

Keywords: venous thromboembolism, lower extremity veins, major surgery, thromboprophylaxis
PEMBANGUNAN RUANG TERBUKA HIJAU KAWASAN PERKOTAAN
Authors: Farida Ida 
Published: March 2019

Ruang terbuka hijau membawa begitu banyak manfaat yang terkandung. Mulai dari sarana untuk mencerminkan identitas daerah, menumbuhkan rasa bangga dan meningkatkan prestise daerah, sarana ruang evakuasi untuk keadaan darurat, sebagai sarana penelitian, pendidikan dan penyuluhan, memperbaiki iklim mikro hingga meningkatkan cadangan oksigen di perkotaan dan tak ketinggalan bermanfaat bagi meningkatkan nilai ekonomi lahan perkotaan. Bahkan terkandung pula manfaat yang lebih bernilai sosial seperti sebagai sarana rekreasi aktif dan pasif serta interkasi sosial atau sebagai sarana aktivitas sosial bagi anak-anak, remaja, dewasa dan manula. Bisa dibilang kebutuhan akan adanya ruang semacam ini di kota-kota besar tak hanya sekedar perlu namun kebutuhan.
PENERAPAN HAK-HAK TERSANGKA DALAM PROSES PENYIDIKAN DIHUBUNGKAN DENGAN KETERBUKAAN INFORMASI DALAM PERSPEKTIF HAK ASASI MANUSIA
Authors: Hermana Anda 
Published: March 2019

Tersangka mempunyai hak-hak tertentu yang harus diberikan menurut Undang-undang dan dijamin diberikannya hak-hak tersebut sesuai dengan hak asasi manusia. Hak mendapatkan informasi merupakan hak asasi manusia. Badan publik berkewajiban menjamin hak-hak tersebut sesuai dengan Undang-Undang Nomor 14 Tahun 2008 tentang Keterbukaan Informasi Publik
ASAS ULTIMUM REMIDIUM DALAM PENEGAKAN HUKUM ADMINISTRASI PERLINDUNGAN DAN PENGELOLAAN LINGKUNGAN HIDUP
Authors: Hardiman Dindin M 
Published: March 2019

Penegakan hukum lingkungan dapat dilakukan secara preventif dan represif, sesuai dengan sifat dan efektivitasnya. Penegakan hukum yang bersifat preventif, berarti bahwa pengawasan aktif dilakukan terhadap kepatuhan kepada peraturan tanpa kejadian langsung yang menyangkut peristiwa konkrit. Instrumen bagi penegakan hukum preventif adalah penyuluhan, pemantauan dan penggunaan kewenangan yang sifatnya pengawasan (pengambilan sampel, penghentian mesin-mesin dan sebagainya). Penegakan hukum lingkungan yang bersifar represif dilakukan dalam hal perbuatan yang melanggar peraturan dan bertujuan untuk mengakhiri secara langsung perbuatan terlarang. Untuk menghindari penindakan pidana secara berulang-ulang, pelaku sendirilah yang harus menghentikan keadaan itu.Pendekatan penegakan hukum lingkungan di indonesia dapat ditempuh dengan empat cara pendekatan, yaitu : Pendekatan Command And Control (CAC), pendekatan ekonomi, pendekatan perilaku (behaviour), pendekatan pendayagunaan tekanan publik (public pressure). Penegakan hukum administrasi. Asas subsidiritas (di dalamnya terdapat asas precautionary) dan asas ultimum remidium sangat berkaitan erat dengan penegakan hukum administrasi. Kata Kunci: Asas Ultimum Remidium, penegakan hukum lingkungan, hukum administrasi.
ANTISIPASI BANK UNTUK MENGHINDARI KREDIT MACET YANG DITIMBULKAN OLEH KERUGIAN DEBITUR AKIBAT PENCEMARAN LINGKUNGAN
Authors: Herlina Nina 
Published: March 2019

ABSTRAKSektor keuangan dan perbankan sebagai bagian dari entitas bisnis tentunya tidak terlepas dari hal ini, walaupun memang tidak secara langsung menyumbang pencemaran lingkungan yang tinggi karena tingkat penggunaan energi, pembuangan limbah, dan kegiatan lainnya pun cenderung lebih rendah dibanding sektor lainnya. Bagaimanpun juga, memelihara kelestarian lingkungan hidup merupakan salah satu bentuk tanggung jawab sektor keuangan dan perbankan, yang juga dituntut untuk senantiasa mengontrol dan mengelola dampak lingkungan yang dihasilkan dari pelaksanaan kegiatan bisnisnya.Penyebab timbulnya kredit bermasalah sendiri dapat disebabkan faktor internal dan eksternal. Faktor Internal antara lain disebabkan oleh kebijakan perkreditan yang kurang menunjang, kelemahan sistem dan prosedur penilaian kredit, pemberian dan pengawasan kredit yang menyimpang dari prosedur, itikad yang kurang baik dari pemilik, pengurus, dan pegawai bank. Sedangkan faktor eksternal antara lain disebabkan oleh lingkungan usaha debitor, musibah atau kegagalan usaha, persaingan antar bank yang tidak sehat. Selain itu dalam analisis kredit diperlukan adanya antisipasi bank untuk menghindari kredit macet yang ditimbulkan oleh kerugian debitur akibat pencemaran lingkungan. Kata Kunci : Antisipasi, Kredit Macet,Pencemaran Lingkungan
STUDY OF THE PHARMACOLOGICAL ACTIVITY OF LOWMOLECULAR ARGINASE II SELECTIVE INHIBITOR USING A MODEL OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION
Authors: Korokina Liliya V. , Pokrovskii Mikhail V. , Pazhinskii Leonid V. , Kochkarova Indira S. , Korokin Mikhail V. 
Published: March 2019

The aimof the present work was to study the pharmacological activity of a low-molecular arginase II selective inhibitor (low-molecular compound with laboratory code ZB49) with the chemical formula 2-{1-[3-(3-[chloroisoxazole-5-yl) propyl] piperidin-4-yl}-6-(digibroxyboryl) norleucine dihydrochloride) using a model of monocrotaline-induced pulmonary hypertensionMaterials and methods.The work was performed on 40 adult male Wistar rats weighing 180– 220 g. The simulation of monocrotaline pulmonary hypertension was performed on 20 animals using a subcutaneous injection of an alcohol-aqueous solution of monocrotaline (MCT) at a dose of 60 mg/kg in a volume of 0.5 ml per animal. 7 days after the MCT injection, the administration of the studied pharmaceutical substance (PS) (laboratory code ZB49) was started at a dose of 5 mg/kg. ZB49 was administered intragastrically, once a day with the administration duration of 21 days.Results.Under the intragastric FS ZB49 administration at a dose of 5 mg/kg, a statistically significant decrease in the coefficient of endothelial dysfunction, systolic right ventricle pressure (SRVP), average the right ventricle pressure (ARVP), diastolic right ventricle pressure (DRVP), maximum contraction rate (dP/dt max) and minimum contraction rate (dP/dt min) was established at the background of the simulation of monocrotaline-induced pulmonary hypertension. At the same time, a statistically significant positive effect of ZB49 on the blood gas composition was established.Conclusion.The study has confirmed the possibility of using arginase inhibitors to prevent the development of endothelial dysfunction and the disorders of nitric oxide metabolism in pulmonary arterial hypertension. Among the substances of this group, arginase II selective inhibitors should be considered as the most promising.Conflict of interest: the authors declare no conflict of interest.
IN VIVO STUDY OF THE ACTION MECHANISM OF THE RAPITALAM PHARMACEUTICAL SUBSTANCE
Authors: Avdeeva Natal’ya V. 
Published: March 2019

The aimis to study the action mechanisms of the Rapitalam pharmaceutical substance using Parkinsonian syndrome models.Materials and methods.Various effects of a new pharmacological substance, N-chlorophenylmethyl-dihydro-methoxy-methylphenyl-oxopyridazine carboxamide (Rapitalam), were studied in male laboratory mice and rats. During the experiment, the various models of the Parkinsonian syndrome were reproduced: the simulation of the Parkinsonian syndrome by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) neurotoxin, the simulation of haloperidol-induced catalepsy, the simulation of apomorphine-induced stereotypy and the simulation of oxotremorine-induced tremor followed by tests. The following tests were carried out in order to determine the Rapitalam efficacy with regard to symptoms manifested after the MPTP administration in animals: the open field test, the rotarod performance test, as well as the evaluation of the grip strength and the degree of rigidity using the stride length. When simulating the haloperidol-induced catalepsy, a horizontal bar test was performed. After the administration of apomorphine, the severity of stereotypy was assessed in scores. A simulation of oxotremorine-induced tremor in rats was used to study the cholinergic link. After the administration of oxotremorine, the severity of tremor was assessed against the background of administration of the test compounds.Results.During the analysis of the data obtained in the open field and rotarod tests as well as the stride length and the grip force when simulating the Parkinsonian syndrome by introducing MPTP, no intergroup statistical differences were found. Thus, the tested Rapitalam substance in doses of 2 mg/kg, 6 mg/kg and 20 mg/kg and the Levodopa reference drug at a dose of 60 mg/kg had no effect on the indices of motor activity and motor coordination in mice when administered orally for 10 days. Rapitalam in doses of 1 mg/kg, 3 mg/kg and 10 mg/kg as well as the Levodopa reference drug at a dose of 50 mg/kg, did not affect the severity of haloperidol-induced catalepsy and apomorphine-induced stereotypy in rats. Under the administration of oxotremorine to laboratory animals, a statistically significant decrease in the severity of tremor was observed during the Rapitalam administration in doses of 3 mg/kg and 10 mg/kg.Conclusion.Rapitalam is established to have no effect on motor impairment due to dopaminergic mechanisms. The tested substance is characterized by a pronounced cholinoblocking effect at doses of 3 mg/kg and 10 mg/kg.Conflict of interest: the author declares no conflict of interest.
TREATMENT OF STABILE ISCHEMIC HEART DISEASE: IS CORONARY STENTING SUPERIOR OVER DRUG THERAPY?
Authors: Kanorskii Sergei G. , Smolenskaya Natal’ya V. 
Published: March 2019

The results of the most discussed randomized trials of percutaneous coronary intervention (PCI) in comparison with drug therapy (COURAGE and FAME 2) and PCI imitation (ORBITA) in patients with stable coronary heart disease are analyzed. Information on the ongoing ISCHEMIA trial is presented. Different points of view are compared concerning the results of the most important PCI research projects. Factors that can distort the results and the possibilities of their elimination are discussed. The main provisions of the American (2017) and European (2018) Guidelines on myocardial revascularization with a focus on PCI in patients with stable coronary heart disease are described.Conflict of interest: the authors declare no conflict of interest.
MARKERS OF ADAPTATION TO PHYSICAL LOADS IN YOUNG PEOPLE COMMITTED TO HEALTHY LIFESTYLE
Authors: Alekseenko Sergei N. , Gorban’ Vitalii V. , Chernoglazov Konstantin S. , Gorban’ Elena V. 
Published: March 2019

The aimwas to study the gender characteristics of the heart rate variability (HRV) in young people depending on physical loading (FL), associated with habitual physical activity (FA).Materials and methods. 98 practically healthy students of a medical high school with different levels of habitual FA were examined. HRV was studied at short 10-minute intervals at rest and after intense FL with the energy consumption of 72–88 kcal.Results. HRV changes are determined, which depend not only on the FL intensity and the training level of young people, but are also gender-associated. At rest, less pronounced sympathetic tone (LF/HF 0.86±0.04 versus 1.05±0.04, p<0.05) and the predominance of the central mechanisms of the heart rhythm over the autonomous ones (ID 75.3±5.7 versus 55.8±5.5 units, p<0.05) were observed for female respondets as compared to the young men. After intense FL, a more pronounced inhibition of the parasympathetic tone (pNN (50%) 5.4±1.2 vs. 10.2±1.9%, p<0.05) and a more pronounced functional intensity of adaptive reactions (ID 176.6±17.9 against 101.4±14.4 units, p<0.05) were noted for the female respondetns as well.Conclusion.Changes in HRV parameters, which reflect the beneficial effects of physical training on the adaptive responses of the cardiovascular system, have been found in young people with constant, habitually high FA. The application of the HRV research methodology for short periods in dynamics is justified in the practice of health-saving preventive and rehabilitation measures, since it allows the process of optimal adaptation of a person to physical loading to be controlled.Conflict of interest: the authors declare no conflict of interest.
ESTIMATION OF METASTATIC NEOGENESIS IN ASCITIC EXUDATE BY AN AUTOMATED ANALYSIS OF BIOLOGICAL LIQUIDS
Authors: Baranovskaya Irina B. , Samokhina Ol’ga F. , Demidchenko Galina A. , Sysoeva Irina P. 
Published: March 2019

The aimis to carry out an automated analysis of biological liquids for the estimation of metastatic neogenesis in ascitic exudates.Materials and methods.A retrospective analysis of 40 case histories of patients with the ascitic syndrome of non-tumour (cirrhotic) and tumour genesis was performed. Traditional cytology was accompanied by an automated analysis of exudative fluids. The final diagnosis was verified using instrumental and pathomorphological methods. The processing of statistical data included an assessment of the intergroup difference significance.Results.Compared with cirrhotic ascites, the following parameters of the automated analysis of biological fluids are found to be statistically significant (p30% in the atypical cell screening system has been established. In the absence of an acute inflammatory reaction, the presence of eosinophils in the exudate should be interpreted as an indirect marker of a tumour process. According to the data obtained, the content of neutrophils, lymphocytes and monocytes in ascitic fluids does not depend on the nature of the process (p>0.05).Conclusion.The diagnostic capabilities of automated analysis of ascitic fluids are analysed. In the system of differential diagnosis of tumour and non-tumour processes, the following parameters are established to possess the greatest informative value: TCN, HF, and the presence of eosinophils (EO).Conflict of interest: the authors declare no conflict of interest.
STUDY OF THE ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF A NEW NON-OPIOID ANALGESIC BASED ON A SELECTIVE INHIBITOR OF TRPA1 ION CHANNELS
Authors: Beskhmelnitsyna Evgeniya A. , Pokrovskii Mikhail V. , Dolzhikov Aleksandr A. , Avtina Tat’yana V. , Zhernakova Nina I. , Peresypkina Anna A. 
Published: March 2019

The aim is to study the analgesic and anti-inflammatory activity of an innovative molecule under the ZC02-0012 laboratory code belonging to the group of selective blockers of the TRPA1 ion channel.Materials and methods. The study of the ZC02-0012 analgesic activity was carried out by the hot plate and acetic acid writhing tests. The hot plate test was performed on white laboratory mice. ZC02-0012 substance was administered in doses of 1, 3 and 9 mg/kg. Ketorol at a dose of 3.48 mg/kg was chosen as the reference drug. To study the analgesic effects in the hot plate test, intact white laboratory mice were placed on a preheated at 55°C plate to determine the base level of pain sensitivity. Then the test substances were administered to the animals divided into groups, and the hot plate test was repeated after 30, 60, 90 and 120 minutes. To study the analgesic effects in the test of acetic acid writhing, white laboratory rats were injected with the ZC02-0012 substance at doses of 0.46, 1.38, and 4.15 mg/kg. Ketorol at a dose of 1.6 mg/kg was chosen as the reference drug. 30 minutes after intramuscular injection and 60 minutes after intragastric administration, the intraperitoneal administration of a 0.75% solution of acetic acid was carried out at the rate of 1 ml per 100 g of animal weight. Counting the number of writhings started 15 minutes after the injection of acetic acid and continued for 30 minutes. The anti-inflammatory effects of the ZC02-0012 substance were studied using a model of acute exudative inflammation in response to the subplantar introduction of 0.02 ml of 2% formaldehyde aqueous solution into the right hind paw of the mouse. 4 hours after the phlogistic introduction, the mass of the edematous paw was evaluated. ZC02-0012 substance at doses of 1, 3 and 9 mg/kg and the Diclofenac reference drug at a dose of 13.91 mg/kg were administered intragastrically or intramuscularly 45 minutes before the introduction of phlogistic. The presence and severity of anti-inflammatory activity was judged by the inhibitory effect, expressed in percentage.Results. The analgesic activity of ZC02-0012 is found to exceed that for Ketorol in both the intramuscular and intragastric ways of administration according to the results of hot plate tests in doses of 3 and 9 mg/kg and acetic acid writhing in doses of 1.38 and 4.15 mg/kg, while the anti-inflammatory activity of ZC02-0012 at doses of 3 and 9 mg/kg is shown to be comparable to that of Diclofenac. Conclusion. The innovative molecule under the ZC02-0012 laboratory code is established to exhibit a pronounced analgesic and anti-inflammatory activity, thus being prospective for further research.Conflict of interest: the authors declare no conflict of interest.
Perbanyakan Mikro Colocasia esculenta (L.) Schott var. Antiquorum Melalui Penggunaan IAA
Authors: Louw Asnad E , Kesaulya Henry , Lawalata Imelda J 
Published: March 2019

An appropriate in vitro propagation medium is necessary to improve the shoot multiplication ability and seed quality in micro propagation. In the Murashige Shoog in vitro culture medium, plant growth regulator can be added as growth promoter. This study aimed to determine the best IAA concentration for in vitro culture growth of Japanese taro (satoimo). The treatment consisted of 4 IAA concentrations, i.e. I0 (0 mg / l), I1 (0.5 mg/L), I2 (1 mg/L), I3 (1.5 mg/L) in randomized block design, with 5 replicates. The results of this study showed that IAA treatment gave an effect on the time of shoot emergence, shoot number, leaf number and root number of satoimo plantlet. IAA concentration of 0.5 mg/L was the best for satoimo shoot number, whereas 1 mg/L IAA was the best concentration for shoot number, shoot height and leaf number in micropropagation of satoimo.
Keywords: IAA, in vitro culture, Japanese taro, micro propagation

ABSTRAK
Media perbanyakan in vitrosangat diperlukan untuk meningkatkan kemampuan multipikasi tunas maupun kualitas bibit. Media Murashige Shoog (MS)dapatditambahkanzat pengatur tumbuh sebagai pemacu pertumbuhan dalam kultur in vitro.Penelitian ini bertujuan untuk mendapatkan konsentrasi IAA terbaik bagi pertumbuhan talas jepang dalam kulturin vitro. Perlakuan terdiri dari 4 taraf konsentrasi IAA yaitu I0 (0 mg/L), I1 (0,5 mg/L), I2 (1 mg/L), I3 (1,5 mg/L) yang diulang sebanyak 5 kali dalam rancangan acak kelompok. Hasil penelitian ini menunjukan bahwa pemberian IAA berpengaruh nyata terhadap saat muncul tunas, jumlah tunas, tinggi tunas, jumlah daun dan jumlah akar satoimo. Konsentrasi IAA 0,5 mg/L merupakan konsentrasi terbaik untuk pertumbuhan akar dan saat muncul tunas talas satoimo, sedangkan konsentrasi IAA 1 mg/L merupakan konsentrasi terbaik untuk jumlah tunas, tinggi tunas dan jumlah daun satoimo.
Kata kunci: kultur in vitro, talas jepang, IAA, perbanyakan
Hubungan Pertumbuhan Varietas Sagu (Metroxylon sago Rottb) dengan Faktor Lingkungan di Desa Seget Papua Barat
Authors: Suripatty Batseba Alfonsina 
Published: March 2019

A good environment for sago plants is muddy, mineral-rich and organic material, brown groundwater and slightly acidic. Sago lives in the form of clumps, where in one clump there are various growth rates ranging from young plants to fruiting. The optimal amount of rainfall for growth between 2000-4000 mm/year, which is spread evenly throughout the year. This study aims to have inventory and to know the relationship between sago growth factors. Sago inventory results obtained 4 varieties namely Metroxylon sago Rottb var. wahna, M. sago Rottb var. wamda, M. sago Rottb var. wirere and M. sago Rottb var. wafok. The relationships between growth and environmental factors such as soil porosity, water pH, moisture, light, and vegetation produced that in general water has an influence on growth while the humidity factor for all types of places of growth i.e in the flooded areas, temporary areas and dry areas does not affect growth.
Keywords: environmental factor, inventory, sago variety, Seget

ABSTRAK
Lingkungan yang baik untuk tumbuhan sagu adalah daerah yang berlumpur, kaya mineral dan bahan organik, air tanah berwarna coklat dan bersifat agak asam. Sagu hidup dalam bentuk rumpun, dimana dalam satu rumpun terdapat berbagai tingkat pertumbuhan mulai dari tumbuhan muda sampai berbuah. Jumlah curah hujan yang optimal bagi pertumbuhan antara 2.000-4.000 mm/tahun, yang tersebar merata sepanjang tahun. Penelitian ini bertujuan untuk menginventarisasi dan mengetahui hubungan faktor-faktor pertumbuhan sagu. Hasil inventarisasi sagu diperoleh 4 varietas yaitu Metroxylon sago Rottb varietas wahna, M. sago Rottb varietas wamda, M. sago Rottb varietas wirere dan M. sago Rottb varietas wafok. Hubungan pertumbuhan dengan faktor lingkungan porositas tanah, pH air, kelembapan, cahaya, dan vegetasi dihasilkan bahwa secara umum air mempunyai pengaruh terhadap pertumbuhan sedangkan faktor kelembaban untuk semua tipe tempat tumbuh yakni pada daerah tergenang, daerah temporer dan daerah kering tidak mempengaruhi pertumbuhan.
Kata kunci: faktor lingkungan, inventory, Seget, varietas sagu