bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth Pattern of Kidney Cyst Number and Volume in Autosomal Dominant Polycystic Kidney Disease
Authors: Bae Kyongtae T. , Zhou Wen , Shen Chengli , Landsittel Douglas P. , Wu Zhiyuan , Tao Cheng , Chapman Arlene B. , Torres Vicente E. , Yu Alan S.L. , Mrug Michal , Bennett William M. , Harris Peter C. ,   for the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)
Published: May 2019

Background and objectives
To evaluate the growth pattern of kidney cyst number and cyst volume in association with kidney size, demographics, and genotypes in autosomal dominant polycystic kidney disease.

Design, setting, participants, & measurements
Kidney cyst number and cyst volume were measured from serial magnetic resonance images, giving a maximum follow-up of 14.23 years, from 241 patients with autosomal dominant polycystic kidney disease (15–46 years old at baseline). The growth pattern was analyzed, in association with sex, age, height-adjusted total kidney volume, and genotype, using linear mixed models of repeated measurements and tests of interactions with age (as a time-dependent covariate) to assess rates of change over time. Models were also fit using Irazabal class. Genotypic groups were characterized as either (1) PKD1 truncating, PKD1 nontruncating, and PKD2 plus patients with no mutation detected; or (2) in combination with PKD1 mutation strength groups.

Results
Imaging and genetic data were collected (at least one visit) for 236 participants. The mean height-adjusted total cyst number increased exponentially over time from a baseline value of 762 to 1715 at the last clinic visit, while the mean height-adjusted total cyst volume increased exponentially from 305 to 770 ml. Height-adjusted total kidney volume, height-adjusted total cyst number, and height-adjusted total cyst volume were all highly correlated over time. Female participants and participants with larger height-adjusted total kidney volume at baseline showed smaller rates of change in the log of height-adjusted total cyst number and cyst volume. PKD1 was associated with significant increases in both cyst number and volume at a given age, but genotype did not significantly affect the rate of growth.

Conclusions
Both height-adjusted total cyst number and height-adjusted total cyst volume increased exponentially and more than doubled over 14.23 years of follow-up. Compared with PKD2 plus no mutation detected, PKD1 was associated with a greater cyst number and volume at a given age, but no significant difference in the rate of growth.
Filosofía y praxis educativa según Adolfo Sánchez Vázquez
Authors: Arriarán Cuéllar Samuel 
Published: May 2019

En este artículo se intenta comprender la concepción pedagógica de Adolfo Sánchez Vázquez sobre todo como filosofía y praxis de la educación. Primero se revisa el origen de su concepto de praxis educativa, concepto que deriva de Marx. Luego se ejemplifica la aplicación de este concepto en algunos procesos sociales como el movimiento estudiantil y la reforma de la educación superior en México. También se explica el modo en que Sánchez Vázquez realizaba sus cursos y seminarios transmitiendo su teoría pedagógica directamente en la investigación y en la práctica docente en el aula. Finalmente para comprender la teoría pedagógica de este autor que no se reduce al lenguaje del aula sino que abarca diversas situaciones históricas de aprendizaje como la relación general entre gobernantes y gobernados, se hace una descripción de la visión de Sánchez Vázquez de la guerra, la posguerra y el exilio en México.
Ampliación de la oferta de educación superior en México y creación de instituciones públicas en el periodo 2001-2012
Authors: Mendoza Rojas Javier 
Published: May 2019

En el artículo se analizan las políticas instrumentadas en los gobiernos de Vicente Fox Quesada y de Felipe Calderón Hinojosa para la ampliación de la oferta pública de educación superior en los niveles de técnico superior universitario y licenciatura, así como las variaciones de la cobertura que se observaron en las entidades federativas y su desigualdad. Se revisan las estrategias compartidas en ambos sexenios para la creación de instituciones con orientación tecnológica (universidades tecnológicas, universidades politécnicas e institutos tecnológicos), bajo arreglos políticos federalistas, que si bien impulsaron la desconcentración territorial de la oferta, plantean interrogantes sobre la solidez de los procesos de planeación para la expansión del sistema de educación superior con una visión de largo plazo. Se concluye con la identificación de algunos desafíos que se presentan al inicio del gobierno de Enrique Peña Nieto.
Identidades juveniles a partir del uso de las tecnologías en los alumnos de la Licenciatura en Mercadotecnia de la Universidad Juárez Autónoma de Tabasco
Authors: Hérnández-Romero Gladys , Córdova Palomeque Nelly Del Carmen , Cuahonte Badillo Luis Carlos , Arellano Quintanar María Soledad Eleonor 
Published: May 2019

Aquí se presentan los resultados de un estudio sobre jóvenes universitarios del primer ciclo de la Licenciatura en Mercadotecnia y la forma en que incorporan las nuevas tecnologías a su vida cotidiana. El tema se aborda desde la línea de investigación de la innovación tecnológica que cultivan los integrantes del grupo “Innovación Educativa en los Procesos de Enseñanza y de aprendizaje”, Las evidencias aquí mostradas son los resultados de una muestra de 20 estudiantes, a quienes se les aplicó un cuestionario en dos momentos, en el primero, el instrumento constó de 25 preguntas y en el segundo de diez.
Una organización académica transversal y la generación de redes para la formación multi y transdisiciplinaria en el Cinvestav
Authors: Gutiérrez-Serrano Norma-Georgina 
Published: May 2019

Con el interés de comprender cómo se instala en el Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) una orientación transdisciplinaria para la formación de doctores, en este trabajo se identifican y analizan condiciones institucionales que permiten la conformación de posgrados multidisciplinares dentro del Cinvestav. El análisis se desarrolla con base en el enfoque de redes y de producción transdisciplinaria de conocimiento. Se toman en cuenta rasgos del contexto y de la cultura institucional que se encuentran presentes en programas de formación que aquí interesan. Se trabajó con grupos focales, con entrevistas individuales a docentes y egresados.
The Use of G-form as an Assessment Instrument in Arabic Language Teaching Based on HOTS
Authors: Mahmudi Arifka 
Published: May 2019

Recently, Higher Order Thinking Skills is a new issues in Indonesia, because the governmentÂ was inserted HOTS question into national exam in order to develop Indonesian education. One of the problem occuring that Â the students are not familiar to the question given, as the result, theÂ student confuse and complait about it.. Thereby, the need to the assessment instrument that could help teacher and students to challenge it is the must. This study aimed to describe the use of G-form as a assessment instrument in arabic language teaching based on Higher Order Thinking Skills (HOTS), to ascertain availability of g-form features as an assessment instrument in arabic language teaching based on Higher Order Thinking Skills (HOTS), and to analyze the advantages and disadvantages of it. The research used a library research. The data was taken by interview the arabic teacher that use gmail as a test instrument in arabic language teaching based on HOTS, by reading books, national as well as international journals, and other references related to this discussion, and small experiment of g-form made. The result of this study claim that g-form can be used as an assessment instrument in Arabic language teaching based on Higher Order Thinking Skills (HOTS). The second are, although it has many advantages, in the other side, the disadvantages were found as well
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
Authors: Osacka Jana , Horvathova Lubica , Cernackova Alena , Kiss Alexander 
Published: May 2019

Abstract

Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic paraventricular nucleus (PVN). Some of these regions are known to be also stress responsive. This study was designed to determine whether repeated clozapine (CLZ) administration for 7 consecutive days to Wistar rats may modify FosB/ΔFosB expression in the above-mentioned brain areas induced by acute stress or novel stressor that followed 13-day chronic mild stress preconditioning.

Methods. Following experimental groups were used: unstressed animals treated with vehicle/ CLZ for 7 days; 7-day vehicle/CLZ-treated animals on the last day exposed to acute stress – forced swimming (FSW); and animals preconditioned with stress for 13 days treated from the 8th day with vehicle/CLZ and on the 14th day exposed to novel stress – FSW.

Results. In the unstressed animals CLZ markedly increased FosB/ΔFosB immunoreactivity in the ventrolateral septum and PVN. FSW elevated FosB/ΔFosB expression in the medial prefrontal cortex, striatum, and septum. CLZ markedly potentiated the effect of the FSW on FosB/ΔFosB expression in the PVN, but suppressed it in the dorsomedial striatum. Novel stress with stress preconditioning increased FosB/ΔFosB immunoreactivity in the prefrontal cortex, striatum, ventrolateral septum, and the PVN. In the nucleus accumbens the effect of the novel stressor was potentiated by CLZ.

Conclusion. Our data indicate that CLZ may modulate the acute as well as novel stress effects on FosB/ΔFosB expression but its effect differs within the individual brain regions.
Novel insights into genetics and clinics of the HNF1A-MODY
Authors: Valkovicova Terezia , Skopkova Martina , Stanik Juraj , Gasperikova Daniela 
Published: May 2019

Abstract
MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a pathogenic effect of gene mutations. Up to date, 13 MODY genes are known. Gene HNF1A is one of the most common causes of MODY diabetes (HNF1A-MODY; MODY3). This gene is polymorphic and more than 1200 pathogenic and non-pathogenic HNF1A variants were described in its UTRs, exons and introns. For HNF1A-MODY, not just gene but also phenotype heterogeneity is typical. Although there are some clinical instructions, HNF1A-MODY patients often do not meet every diagnostic criteria or they are still misdiagnosed as type 1 and type 2 diabetics. There is a constant effort to find suitable biomarkers to help with in distinguishing of MODY3 from Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). DNA sequencing is still necessary for unambiguous confirmation of clinical suspicion of MODY. NGS (Next Generation Sequencing) methods brought discoveries of multiple new gene variants and new instructions for their pathogenicity classification were required. The most actual problem is classification of variants with uncertain significance (VUS) which is a stumbling-block for clinical interpretation. Since MODY is a hereditary disease, DNA analysis of family members is helpful or even crucial. This review is updated summary about HNF1A-MODY genetics, pathophysiology, clinics functional studies and variant classification.
A systematic review of mindfulness based interventions for children and young people with ADHD and their parents
Authors: Tercelli Illaria , Ferreira Nuno 
Published: May 2019

Abstract

Objective
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent disorders in childhood, which may pose risks in later life such as academic underachievement and anti-social behaviour. It has been suggested that mindfulness-based interventions (MBI) may contribute to positive outcomes with child and adult populations. In this article, we aim to systematically review the literature regarding the effectiveness of MBI on both children with ADHD and their parents.

Method
Seven databases were searched using the PRISMA criteria and included peer-reviewed journals and grey literature.

Results
Ten studies met the inclusion criteria. Findings suggested that MBI had positive results in addressing attention deficits in children with ADHD, but in terms of hyperactivity, the evidence was conflicting. MBI interventions also appear to effectively address parental stress and family functioning. However, the rating from the quality assessment showed several methodological limitations.

Discussion
The current evidence on the impact of MBI on ADHD symptoms is non-conclusive. However, promising data indicated the potential for MBI in addressing parental stress and family functioning. Further research is recommended to overcome the current methodological limitations.
Nicolai Hartmanns Critical Ontology and the Critical Realism of the Berlin School of Gestalt Psychology
Authors: Walter Hans-Jürgen P. 
Published: May 2019

Summary
The author exemplifies the congruency of essential foundations between the critical realism of the Berlin School of Gestalt Psychology (Gestalt theory) and Nicolai Hartmann’s Critical Ontology. For instance, this congruency manifests in the importance given to critical-realistic epistemology – purified from idealistic prejudices, not least prejudices such as production-theoretical ones – connected with an unconditional phenomenology. Altogether, it results in a shared critical distance from scholars of Brentano, such as Husserl and Meinong, as well as from Neo-Kantianism.
Comparison of qPCR and Morphological Methods For Detection of Acarapis Woodi in Honey Bee Samples
Authors: Quintana Silvina , Szawarski Nicolás , Sarlo Gabriel , Medici Sandra , Rivero Mariana , Eguaras Martin , Maggi Matias 
Published: May 2019

Abstract
The honey bee tracheal mite Acarapis woodi is an internal obligate parasite of adult honey bees (Apis mellifera). The small size of the mites and location within the bee’s trachea create a challenge for diagnostic identification. Detailed assessment of low-level mite infestation involves microscopic examination of the bee’s tracheae, but this traditional diagnostic method takes a long time. In recent years, new molecular diagnostic techniques have been developed to identify A. woodi with the use of PCRs. The purpose of this study was to compare the diagnostic sensitivity of microscopic examination and qPCR method for the detection of A. woodi in honey bee samples. Thirty-six samples were analyzed with both methods and qPCR was more sensitive than the microscopic method to detect A. woodi. This work demonstrates the practical application of molecular technology as a support tool for surveys and contingency management and to provide robust surveillance data on the presence or absence of A. woodi in honey bee colonies.
Sepsis in Acute Mediastinitis – A Severe Complication after Oesophageal Perforations. A Review of the Literature
Authors: Mureșan Mircea , Mureșan Simona , Balmoș Ioan , Sala Daniela , Suciu Bogdan , Torok Arpad 
Published: May 2019

Abstract

Background
Despite recent advancements in antibiotic therapy and the progress made in critical care and modern diagnostic methods, acute mediastinitis continues to be a severe condition.

Diagnosis and treatment
Acute mediastinitis can occur in the context of cardio-thoracic surgery, oesophageal perforations and oropharyngeal infections condition. Forty-five percent of oesophageal perforations occurs during simple endoscopy. Spontaneous perforation (Boerhaave syndrome) accounts for 15% of perforations, and twelve percent are due to the ingestion of foreign bodies. Other causes include blind or penetrating trauma, and circa 9% to intraoperative lesions. CT scan is the standard investigation that reveals direct signs of mediastinitis.
The oral administration of contrast substances can underscore the level of oesophageal perforation. Conservative treatment is the first-choice treatment and surgical treatment is reserved only for specific situations.
The principles of surgical treatment consist of drainage, primary suture, oesophageal exclusion with or without the application of oesophagectomy, endoscopic vacuum wound assisted therapy of the perforation and associated paraoesophageal mediastinal drainage and endoscopic stenting associated with drainage.

Conclusions
The lowest mortality rate is recorded in patients with perforations diagnosed less than twenty-four hours after the onset of symptoms. Surgical treatment remains the gold standard especially in cases of thoracic and abdominal perforations while further investigations are mandatory before endoscopic stenting is carried out.
Refractory Lactic Acidosis and an Approach to Its Management - A Case Report
Authors: He Yingke , Ong John , Ong Sharon 
Published: May 2019

Abstract

Background
Lactic acidosis (LA) is a complication of diseases commonly seen in intensive care patients which carries an increased risk of mortality. It is classified by its pathophysiology; Type A results from tissue hypo-perfusion and hypoxia, and Type B results from abnormal metabolic activity in the absence of hypoxia. Reports of the co-occurrence of both types have been rarely reported in the literature relating to intensive care patients. This case report describes the challenging management of a patient diagnosed with both Type A and Type B LA.

Case presentation
A 55-year-old female with newly diagnosed diffuse large B-cell lymphoma (DLBCL) developed hospital-acquired pneumonia, respiratory failure, shock and intra-abdominal septicaemia from a bowel perforation. Blood gases revealed a mixed picture lactic acidosis. Correction of septic shock, respiratory failure and surgical repair caused initial improvement to the lactic acidosis, but this gradually worsened in the intensive care unit. Only upon starting chemotherapy and renal replacement therapy was full resolution of the lactic acidosis achieved. The patient was discharged but succumbed to her DLBCL several months later.

Conclusion
Type A and Type B LA can co-occur, making management difficult. A systematic approach can help diagnose any underlying pathology and aid in early management.
Pyruvate Dehydrogenase Complex Deficiency: An Unusual Cause of Recurrent Lactic Acidosis in a Paediatric Critical Care Unit
Authors: Gupta Neha , Rutledge Chrystal 
Published: May 2019

Abstract
Pyruvate dehydrogenase complex deficiency (PDCD) is a rare neurodegenerative disorder associated with abnormal mitochondrial metabolism. Structural brain abnormalities are common in PDCD. A case of a patient with PDCD with an unusual presentation is described. A 20-month-old boy with hypotonia and developmental delay, presented with hypoxia and respiratory distress due to bronchiolitis. During hospitalisation, he was prescribed PediaSure® feeds. Two days after starting these feeds, he developed respiratory arrest requiring intubation. His blood gas before arrest revealed lactate of 8.9 mmol/L despite normal haemodynamics. After stabilisation and a period of compulsory fasting, subsequent feeding with PediaSure® resulted in the recurrence of lactic acidosis. A metabolic workup revealed an elevated serum pyruvate level. Brain MRI was normal. Skeletal muscle biopsy confirmed PDCD. The most common cause of PDCD is a mutation in the X-linked PDHA1 gene. The severity of PDCD can range from neonatal death to more delayed onset of symptoms as in our index case. Normal brain MRI is reported in only 2% of patients with PDCD. There is no effective treatment for PDCD. In patients with proximal muscle weakness and feeding intolerance with glucose-containing feeds, the presence of lactic acidosis should raise the suspicion of PDCD irrespective of the patient's age and normal MRI.
Comparative evaluation of multilevel DC link inverter using symmetrical and asymmetrical DC sources
Authors: Hamidi Muhammad Najwan , Ishak Dahaman , Zainuri Muhammad Ammirul Atiqi Mohd 
Published: May 2019

Abstract
This paper presents a comparative evaluation of multilevel DC link inverter of photovoltaic (PV) renewable energy system using either symmetrical or asymmetrical dc sources. The four units of dc source can have the same dc voltage level, ie 81.32 V, resulting in symmetrical dc sources. The asymmetrical dc sources consist of input dc voltages in binary sequence, 21.68 V, 43.37 V, 86.74 V and 173.48 V. The boost converters with maximum power point tracking (MPPT) capability which is regulated by perturb and observe (P&O) based control are connected between the PV panels and the four dc sources. The varying dc voltages from the PV panels are regulated to track the maximum power available regardless of the irradiance and temperature conditions. The symmetrical dc sources will facilitate the generation of 9 levels of staircase ac waveform rms of 230 V after the H-bridge inverter. Whereas, the asymmetrical dc sources are able to produce 31 levels of staircase ac waveform also with rated rms 230 V. Detailed analysis and comparison on the powers, ac output voltage, output current, total harmonic distortions, and MPPT achievement are described.
Identification of nonlinear block-oriented systems with backlash and saturation
Authors: Vörös Jozef 
Published: May 2019

Abstract
A new approach to modeling and identification of discrete-time nonlinear dynamic systems with input backlash and output saturation nonlinearities is presented. The proposed three-block cascade mathematical model results from successive applications of the key-term separation principle. This provides special nonlinear model description that is linear in parameters. An iterative technique with internal variable estimation is proposed for estimation of all the model parameters based on measured input/output data and minimizing the least-squares criterion. Illustrative example of cascade system identification with backlash and saturation is included.
Utilizing the synchronous condenser for robust functioning of wind farm implanted electric grid
Authors: Igbinovia Famous Oghomwen , Fandi Ghaeth , Kubica Juraj , Muller Zdenek , Janicek Frantisek , Tlusty Josef 
Published: May 2019

Abstract
Present-day electricity grids are equipped with sophisticated devices that allow to meet various grid code requirements. These include reactive and active power controls to ensure robust functioning of the grid. Robust operation of the electricity grid entails favourable voltage and frequency profile adjustments that can be achieved through reactive and active power controls. This study presents the synchronous condenser capability of providing voltage regulation and reactive power output, and the active power possibility path of a type-3 wind machine for dynamic state conditions and voltage stability issues. Simulations carried out in the MATLAB/Simulink environment prove the efficiency of the proposed methodology.
Design of equi-interference lines in CDMA mobile systems
Authors: Lebl Aleksandar , Mitić Dragan , Markov Žarko , Tomić Željka 
Published: May 2019

Abstract
In this paper it is presented the process of designing equi-interference lines in the CDMA mobile telephony systems. It is proved that shape of these lines in one base station cell is determined by emission characteristics of that base station and the base stations, which form the first ring around the considered cell. The influence of base stations from the other rings after the first one is dominantly noticed as the interference increase in each point of equi-interference line. The value of interference increase depends on the value of environmental propagation coefficient. For its small values it is necessary to consider the influence of base stations from more than twenty rings around the analyzed cell, while for great values it is enough to consider only two rings.