bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTIMATIVA E DISTRIBUIÇÃO DE PRECIPITAÇÕES DECENDIAIS PARA O ESTADO DO PARANÁ
Authors: Sampaio Silvio César , Queiroz Manoel Moisés Ferreira de , Frigo Elisandro Pires , Longo Adair José , Suszek Morgana 
Published: November 2018

ESTIMATIVA E DISTRIBUIÇÃO DE PRECIPITAÇÕES DECENDIAIS PARA O ESTADO DO PARANÁ Silvio César Sampaio; Manoel Moisés Ferreira de Queiroz; Elisandro Pires Frigo; Adair José Longo; Morgana SuszekSetor de Recursos Hídricos e Saneamento Ambiental (RHESA), Universidade Estadual do Oeste do Paraná, Cascavel, Paraná, ssampaio@unioeste.br 1 RESUMO O objetivo deste trabalho foi estimar a precipitação provável com 75% de probabilidade nos períodos decendiais, a partir de dados diários de precipitação de 22 postos de medição, com um mínimo de 12 anos de observação, fazendo-se uso das distribuições Gama e Log-normal. Os testes Qui-quadrado e Kolmogorov-Smirnov, ambos com 5% de significância, foram utilizados para verificar a aderência das distribuições às condições pluviométricas decendiais do estado do Paraná. Os resultados mostraram que a distribuição Gama ajustou-se mais adequadamente às condições pluviométricas do estado nos períodos estudados. Os meses mais chuvosos são janeiro e fevereiro, enquanto os mais secos, são julho e agosto. O estado do Paraná apresenta aumento na quantidade de precipitação pluviométrica na direção litoral/oeste e norte/sul. UNITERMOS: probabilidades, chuva provável, distribuição Gama, distribuição log-normal. SAMPAIO, S.C.; QUEIROZ, M.M.F. de; FRIGO, E.P.; LONGO, A.J.; SUSZEK, M.DISTRIBUTION AND ESTIMATE OF PROBABLE 10-DAY PRECIPITATION INPARANÁSTATE 2 ABSTRACT The objective of this study was to estimate the probable 10-day precipitation, 75% probability, using daily rainfall data from 22 rain gauge sites, which had been collecting observation data for at least 12 years; Gamma and Log-normal distributions were used. Qui-square and Kolmogorov-Smirnov tests, at 5% significance, were utilized to verify distribution adherence to 10-day rainfall conditions in the state of Paraná. The results showed that Gamma distribution was more adequately adjusted to rainfall conditions in the studied periods than Log-normal distributions. January and February are the rainiest months whereas July and August are the driest ones. There is an increase in the east/west and north/south bound rainfall inParanastate. KEYWORDS: probabilities, probable rainfall, gamma distribution, log-normal distribution.
DISTÂNCIA DA REDE ELÉTRICA QUE VIABILIZA O USO DE MOTORES DIESEL EM ÁREAS IRRIGADAS DO BRASIL
Authors: Monteiro Rodrigo Otávio Câmara , Ferraz Priscylla , Coelho Rubens Duarte , Santos Ronaldo Antônio do 
Published: November 2018

DISTÂNCIA DA REDE ELÉTRICA QUE VIABILIZA O USO DE MOTORES DIESEL EM ÁREAS IRRIGADAS DO BRASIL Rodrigo Otávio Câmara Monteiro; Priscylla Ferraz; Rubens Duarte Coelho; Ronaldo Antônio do SantosEscola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba, SP rocamara@esalq.usp.br 1 RESUMO Na maioria das regiões do país, a energia elétrica aparece como a alternativa, economicamente mais viável, no acionamento de bombas em áreas irrigadas, o que justifica seu uso por aproximadamente 70% dos irrigantes. No entanto, em determinadas situações, não se dispõe, nas proximidades, de rede elétrica, o que passa a viabilizar o uso de motores diesel. Este trabalho, portanto, propôs a análise dos custos horários de bombeamento com a operação de motores diesel e elétricos nas 5 regiões do Brasil. Considerou-se as composições tarifárias verde, azul e convencional, período de irrigação de 2, 4, 6 e 8 meses por ano e operação no horário de ponta e fora de ponta. Para essa avaliação, foi considerado um motor diesel e elétrico, de potência comercial de 50 cv. O ponto de equilíbrio entre motor elétrico e diesel foi determinado pela distância da rede de energia elétrica até o local de consumo. A viabilidade de utilização dos motores diesel em relação ao acionamento de motores elétricos foi encontrada a partir de distâncias da rede de transmissão elétrica de1,32 a8,71 km, sendo a primeira a condição mais atrativa, encontrada na região Sudeste, com 2 meses/ano de irrigação, na tarifa convencional. UNITERMOS: Energia elétrica, irrigação, custo de bombeamento MONTEIRO, R. O. C.; FERRAZ, P.; COELHO, R. D.; SANTOS, R.A. do. VIABILITY OF DIESEL MOTOR USE IN IRRIGATED AREAS OF BRAZIL DUE TO DISTANCE FROM ELECTRIC POWER LINES 2 ABSTRACT In most agricultural areas ofBrazil, electric power seems to be the most feasible economic alternate methods for the functioning of pumps in irrigated areas, therefore 70% of irrigation systems use it. However, the viability of electric power lines is restricted to only one part of rural areas, making it necessary the implementation of diesel engines as a source of electrical power for water management. The aim of this study was to investigate the viability of the use of electric energy and diesel motors. For this study, an electric motor and a diesel one, both of 50HP potency, were evaluated, taking into consideration the following variables: tax composition, areas of the country and number of operation hours per year. The viability of the diesel engine use in relation to implantation of electric motors was determined from distances that ranged from1.32 kmup to8.71 kmbetween the consumption place and the electric power lines. The most favorable condition is the one found in the southeast of the country: 2 irrigation months/year.KEYWORDS: Electric energy, irrigation, pump costs
Takotsubo Cardiomyopathy During Anti-HER2 Therapy for Metastatic Breast Cancer
Authors: Lees Caitlin , Yazdan-Ashoori Payam , Jerzak Katarzyna J. , Gandhi Sonal 
Published: November 2018

Abstract
Human epidermal growth factor receptor 2 (HER2)-targeted antibodies, including pertuzumab and trastuzumab, improve overall survival and progression-free survival among women with HER2-positive metastatic breast cancer, but grade ≥3 cardiotoxicity occurs in approximately 8% of cases. Here we report a case of Takotsubo cardiomyopathy associated with the use of dual anti-HER2 therapy in a 63-year-old woman who presented to the emergency department with an 8- to 10-hour history of progressive dyspnea after completing her third cycle of pertuzumab plus trastuzumab in addition to nab-paclitaxel chemotherapy. To our knowledge, this patient represents the first reported case of Takotsubo cardiomyopathy associated with pertuzumab plus trastuzumab combination therapy in the literature.
Modulation of Premetastatic Niche by the Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor Pazopanib in Localized High-Risk Prostate Cancer Followed by Radical Prostatectomy: A Phase II Randomized Trial
Authors: Maughan Benjamin L. , Pal Sumanta K. , Gill David , Boucher Kenneth , Martin Christopher , Salgia Meghan , Nussenzveig Roberto , Liu Ting , Hawks Josiah L. , Batten Julia , Nachaegari Gayatri , Stephenson Robert , Lowrance William , Jones Jeremy , Dechet Christopher , Agarwal Neeraj 
Published: November 2018

Abstract

Lessons Learned
Pazopanib was not effective in altering the premetastatic niche in the neoadjuvant setting. Pazopanib was safe and well tolerated without any new safety signals.

Background
Vascular endothelial growth factor receptor 1 (VEGFR1) expressing myeloid-derived suppressor cells (VEGFR1+ MDSCs) potentially foster metastases by establishing a premetastatic niche. In a preclinical study, VEGFR1+ clustering in lymph nodes (LNs) independently predicted time to biochemical recurrence (TTBR) in localized prostate cancer [1]. The hypothesis was that neoadjuvant pazopanib therapy will decrease VEGFR1+ clusters in pelvic lymph nodes and improve outcomes.

Methods
This is a phase II trial (NCT01832259) of neoadjuvant pazopanib 800 mg versus placebo daily for 4 weeks in high-risk localized prostate cancer. The primary endpoint was a decrease in VEGFR1+ MDSC clustering assessed by immunohistochemistry (IHC) analysis. Secondary endpoints were safety, feasibility, and TTBR.

Results
Thirty patients were randomized to pazopanib versus placebo, with 15 patients randomized to each arm. Demographic and disease characteristics were similar in both arms. There was no difference in the VEGFR1+ clustering between the treatment arms (p = .345). Neoadjuvant therapy with pazopanib was well tolerated, and surgical complications were similar in both arms.

Conclusion
Neoadjuvant pazopanib therapy did not alter the premetastatic niche; however, treatment targeting vascular endothelial growth factor (VEGF) in the preoperative period was safe and feasible, which may open up the avenue to investigate novel combinatorial regimens, including a VEGF inhibitor in combination with immune checkpoint inhibitor in this setting.
Macroeconomic Effects of Defense Expenditures in Turkey
Authors: ŞİT Mustafa 
Published: November 2018

In
this study, the effects of defense expenditure on the macroeconomic majorities
of Turkey such as economic growth, inflation, current account balance, import
and employment have been investigated.&nbsp;
The relation in question has been analysed over the period between
1980-2016 by structural breaks unit root test, causality tests of Toda-Yamamoto
and Granger. As a result of this study, it has been detected that defense
expenditures are effective on inflation, current account balance and import.
Unlike previous studies which same tests were applied, causality from current
account balance and GDP to defense expenditures was determined in this article.
Evidence has shown that, for Turkish economy, defense expenditures are
effective on macroeconomics variables.
A situação política e a possibilidade da luta da classes nos EUA
Authors: Catalinotto John 
Published: November 2018

Pessoas de todo o mundo colocam aos analistas e aos marxistas dos Estados Unidos as seguintes questões: quais são as condições políticas e económicas hoje existentes no centro do imperialismo mundial? A eleição de Barack Obama mudou alguma coisa? Existe um movimento anti-imperialista que possa pôr obstáculos ao militarismo dos Estados Unidos? Há possibilidade de a classe trabalhadora dos Estados Unidos responder com luta de classes ao ataque desencadeado contra as suas condições de vida?
Dialéctica de las crisis
Authors: Gambina Julio Cesar 
Published: November 2018

Ante este panorama, la situación de crisis capitalista con epicentro en los países desarrollados -especialmente en los Estados Unidos- reabre la discusión sobre el modo de organización económico de la sociedad contemporánea, al tiempo que nos invita a reflexionar acerca de la naturaleza de la crisis, sus causas, consecuencias y posibles salidas. Queremos ser precisos en nuestra definición de la crisis, que no alude sólo a la cuestión del ciclo económico, sino -y principalmente- a los límites estructurales en la obtención de ganancias, la consiguiente acumulación capitalista y el proceso de dominación política que de allí se deriva. La crisis es producto de factores internos del proceso de producción y reproducción, del cual la sobreproducción de mercancías y de capitales constituye el fundamento principal, conjuntamente con los conflictos laborales y sociales por la disputa de la renta generada. Es una lucha diversa por el salario, la vivienda, la salud, la educación y la apropiación social de valores socioculturales construidos históricamente, llevadas adelante por amplios sectores populares (trabajadores informales, pequeños campesinos, artesanos, comunidades de pueblos originarios, organizaciones territoriales, comunitarias, etc.) En rigor, ambas facetas son parte indisoluble del orden vigente, uno como proceso de trabajo y el otro de lucha de clases. Hay crisis cuando el capital no puede reproducir su ciclo como capital dinero, como capital productivo o como capital mercancía, procesos cruzados esencialmente por el conflicto de clase.
Da acumulação por despossessão às formas embrionárias da emancipação humana
Authors: Becher Mariela , Gomes Villar Andre 
Published: November 2018

O presente trabalho tem por objetivo analisar a crise do sistema capitalista a partir dos anos 1970, sem precedentes na história do capital, pensando a revolução tecnocientífica como a última alavanca produzida pelo sistema, junto com a maquinaria de guerra e produção de armas; assim como também a criminalização e militarização da vida social. Frente a este panorama se torna indispensável pensar as possibilidades de emancipação humana, e como elas aparecem de forma embrionária em algumas experiencias que se desenvolvem a partir dos anos 1990, com o colapso da modernização.
Envelhecer hoje: entre pesquisas, políticas e poesia.
Authors: Rabelo Desiree Cipriano 
Published: November 2018

Durante muito tempo pensar sobre envelhecimento presumia adentrar-se em questões morais, religiosas, românticas. A obediência devida a eles, tem raízes nas próprias escrituras: “Levanta-te diante dos cabelos brancos e sê cheio de respeito por um velho": (Lev 19,32). À velhice estão relacionados atributos como sabedoria e conhecimento. Mas alcançá-la significa, também, aproximar-se da morte, do inexorável: “Viver é envelhecer”, adverte Simone de Beauvoir. O que resulta em sentimentos ambíguos: “Quem é esse que me olha e é tão mais velho que eu? (...) Parece meu velho pai - que já morreu! Como pude ficarmos assim?” (Maria Quintana).
Integração sul-americana: um balanço crítico
Authors: Saludjian Alexis 
Published: November 2018

Este artigo trata da dimensão regional do modelo de desenvolvimento da América do Sul. A primeira seção apresentará um balanço dos modelos de integração econômica regional a partir do conceito de regionalismo aberto. A segunda tratará dos processos de integração regional na América do Sul (Mercosul e Comunidade Andina de Nações) depois da década de 1990. A terceira discutirá o panorama político da região na década de 2000 e a tentativa de renovação das proposições sobre integração regional. Finalmente, serão analisados os resultados empíricos da integração econômica e da inserção internacional da América do Sul na economia mundial em termos comerciais (1985-2009).
PECULIARITIES OF DIFFUSION OF INNOVATIONS IN THE REGIONS OF UKRAINE
Authors: Kalnyi S. V. , Virchenko V. V. 
Published: November 2018

Article is devoted to analysis of the scientific, technical and innovative development of Ukraine for the purpose of identification of peculiarities of diffusion of innovations in the regions.Relevant issues of diffusion of innovations are generalized using results of the corresponding theoretical and practical studies, which were conducted in the countries with market economy and with the high level of information technology development. Peculiarities of diffusion of innovations in areas with different population density, scientific and business environments are considered. Indicators of scientific, technical and innovative development of the regions of Ukraine are analyzed using the method of principal components. Authors singled out from the general array of parameters specific indicators, which characterize the principal components of innovative development, among which there are levels of research activity, innovation activity, human and financial potential. Consolidation of regions depending on the level of indicators, which characterize the principal components of innovative development is performed. Correlation between the value of corresponding indicators and levels of urbanization and industrial development of the regions are clearly established.Grouping of regions of Ukraine depending on the level of development of a human capital, amounts of funding of R&D and innovation activities, level of implementation of innovative products and technologies in production is performed.Need of increasing the availability of disaggregated statistics related to innovation activity of the enterprises and scientific institutions in Ukraine is proved. Ways of acceleration of diffusion of innovations and regional alignment of indicators of innovative development in Ukraine are defined, including: strengthening of the state innovation policy to foster development of regional and industry networks of exchange of the innovation experience, knowledge, open information on new developments and possibilities of financing of the innovation projects; support of creation in rural territories of partnership around the innovation projects to ensure SME greening and rapid implementation of the latest innovation processes.
THE ECONOMIC-MATHEMATICAL MODELLING OF PROCESSES OF OPTIMIZATION OF SUGAR RAW MATERIALS’ LOGISTICS AT SUGAR FACTORIES
Authors: Lagovska O. А. , Denysiuk O. G. , Ovcharenko Yе. І. , Andryeyeva N. M. 
Published: November 2018

The mathematical model of proceeding in the supplies of agricultural on a factory-producer under force-majeure circumstances of their deficit products is suggested. It enables bringing in to the supply of feedstock not only own sources but also alternative ones. Small and middle farmers became such suppliers. This helps to reduce the risk of failures in raw materials’ supply to sugar factories, as well as to integrate the interests of large associations of sugar producers with the interests of small and medium producers. This also helps to solve the tasks of socio-economic development of rural areas as it provides sales to small and medium agroproducers.The mathematical formulation of the problem is complicated by the presence of probabilistic parameters. Therefore, in the case of mathematical modeling, a stochastic network model was used.The complexity of the task of organizing the supply of raw materials by small and middle producers is due to the fact that the set of sugar beet suppliers is an open heterogeneous system, and the consumer is a link of a centralized association with a hierarchical structure.The factor of heterogeneity of the suppliers’ set is due to the fact that each of them acts autonomously and even has no information about the actions of other suppliers.The mathematical model allows to predict the time of implementation of the project and to solve the task concerning delivery of raw materials of the quantity required, for a given period of time, from a substantial number of autonomous suppliers. The developed mathematical model has allowed to take into account the influence of probabilistic factors on the decisive factor - the timely organization and restoration of the necessary resource for the smooth operation of sugar production.Independent substructures, by definition, do not have access to the centralized network schedule of the producer. In order to resolve this contradiction, the following decision is taken. For each of the autonomous primary producers, their own network schedule is created.The developed mathematical model can be used for other cases of emergent stocks replenishment, urgent formation of commodity batches of agricultural products.
FEATURES OF THE FORMATION OF FINANCIAL AND CREDIT SYSTEMS IN A MULTI-FACETED ECONOMY
Authors: Voronin V. M. , Kozachenko O. I. , Kutashov I. V. , Kotliarov V. O. 
Published: November 2018

It is determined that the formation of the financial system of Ukraine took place simultaneously with the development of its statehood. The components of the financial and credit system, which in total are two subsystems: financial and credit, are analyzed. Each of these subsystems is divided into spheres, and those in turn — on the links, subdivisions, etc. Although each element of the financial and credit system has its own organization, mechanism and functioning, they are all closely interconnected and have a great influence on the development of the national economy. It is noted that the banking system in Ukraine is under construction. It is built on the western type. Today in most countries of the world there is a two-tier banking system. In such a system, relations between banks are formed in two planes: vertically and horizontally.As the analysis shows, the market mechanism is not omnipotent. According to the goals of a democratic society, the market can not provide a noble redistribution of profits. In a crisis situation, the market has little effect on the stabilization of the economy and the effective functioning of the credit and financial system. Certain investment funds, insurance companies and credit and financial institutions are engaged in activities that are unusual for them, harming the public: attracting contributions from the population that perform the functions of savings and commercial banks on the principle of a pyramid, thus causing a wave of bankruptcies. It is substantiated that the public purpose of the financial and credit system characterizes the functions and gives a clear idea of its role, that is, the "work" that this system performs in society. The functions of the financial and credit system are an objective and dynamic phenomenon. Each of them is formed and developed with the development of financial and credit relations and the economic environment in which this system operates. It was concluded that financial and credit relations are one of the most important categories of a market economy, which reflects the real relations and interconnections of economic entities in the economic life of society. The financial and credit interaction of banks and enterprises has always been and remains an important lever for stimulating the development of production and reflects the economic relationship with the reverse movement of borrowed value.
АНТИКРИЗОВЕ УПРАВЛІННЯ ЯК ОСНОВА ВДОСКОНАЛЕННЯ ФІНАНСОВОЇ ДІЯЛЬНОСТІ ПІДПРИЄМСТВА
Authors: Banera N. P. , Heley L. O. , Pylypenko S. M. 
Published: November 2018

Обґрунтовано, що одним із шляхів поліпшення фінансового стану підприємства є вибір правильної антикризової стратегії, яка б гарантувала зниження фінансових проблем, ризиків банкрутства та ліквідації підприємства, координацію узгодження управлінських рішень із практичними діями, виявляла пріоритетність проблем і забезпечувала поліпшення діяльності в умовах кризи. Доведено, що вживання антикризових заходів має бути комплексним, обов’язковим при цьому є здійснення постійних досліджень. З’ясовано, що основними антикризовими заходами для підприємств повинні стати: зменшення чи оптимізація витрат, ефективне використання маркетингової та кадрової політики, правильне використання процесів планування, оптимізація бюджетування тощо. Запропоновано застосування антикризових заходів на кожному з етапів життєвого циклу підприємства, зокрема, на стадії створення підприємства повинна бути чітко поетапно розроблена стратегія просування товару на ринок, а також цінова та комунікаційна стратегія; на стадії підйому підприємства для попередження кризової ситуації потрібне використання ефективної та професійної системи управління, за потреби залучення кваліфікованих спеціалістів; на стадії зрілості мета вживання антикризових заходів полягає у стабілізуванні ситуації та недопущенні зменшення ринкового сегмента; стадія реорганізації чи банкрутства характеризується використанням заходів, спрямованих на оптимізацію бюджетування. Установлено, що досягнення позитивних результатів від використання інструментів антикризового управління можна за комплексного їх застосування та цілеспрямованого узгодження дій між працівником і керівником, чіткої послідовності виконання поставлених завдань, терміновості ухвалення рішень тощо, важливе значення при практичному використанні антикризового управління має оптимізаційний економічний характер його застосування, що може бути виявлено шляхом постійного моніторингу середовища підприємства із використанням комплексу маркетингових досліджень, методів стратегічного аналізу і контролінгу.