bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking two worlds in polymer chemistry: The influence of block uniformity and dispersity in amphiphilic block copolypeptoids on their self‐assembly
Authors: Gangloff Niklas , Höferth Marcel , Stepanenko Vladimir , Sochor Benedikt , Schummer Bernhard , Nickel Joachim , Walles Heike , Hanke Randolf , Würthner Frank , Zuckermann Ronald N. , Luxenhofer Robert 
Published: February 2019

AbstractThe self‐assembly of block copolymers has captured the interest of scientists for many decades because it can induce ordered structures and help to imitate complex structures found in nature. In contrast to proteins, nature's most functional hierarchical structures, conventional polymers are disperse in their length distribution. Here, we synthesized hydrophilic and hydrophobic polypeptoids via solid‐phase synthesis (uniform) and ring‐opening polymerization (disperse). Differential scanning calorimetry measurements showed that the uniform hydrophobic peptoids converge to a maximum of the melting temperature at a much lower chain length than their disperse analogs, showing that not only the chain length but also the dispersity has a considerable impact on the thermal properties of those homopolymers. These homopolymers were then coupled to yield amphiphilic block copolypeptoids. SAXS and AFM measurements confirm that the dispersity plays a major role in microphase separation of these macromolecules, and it appears that uniform hydrophobic blocks form more ordered structures.
Validation of the Poisoning Severity Score (PSS) in suicidal behavior by self‐poisoning
Authors: Conner Kenneth R. , Wiegand Timothy J. , Gorodetsky Rachel , Schult Rachel , Pizzarello Edmund , Kaukeinen Kimberly 
Published: February 2019

Intentional self‐poisoning is the leading method of suicidal behavior leading to medical attention worldwide. The medical severity of self‐poisoning events has major treatment, prognostic, and medico‐legal implications, yet measures of severity are limited. The Poisoning Severity Score (PSS) is a widely used scale but validation data are limited, particularly in the study of suicidal behavior per se. The sample was a consecutive series of intentional self‐poisoning patients aged 13 to 65 treated at a large university medical center (n = 673). PSS scores, with a range 0 (none) to 4 (death), were calculated along with other structured clinical data and analyzed in a series of linear regressions adjusted for age and sex. Higher PSS scores were consistently associated with greater medical morbidity and more intensive acute medical treatments, and nearly all effect sizes were large. Results support the validity of the PSS in hospital‐treated self‐poisoning patients.
Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer
Authors: Wang Yun , Sun Xiao‐qiang , Lin Hao‐cheng , Wang De‐shen , Wang Zhi‐qiang , Shao Qiong , Wang Feng‐hua , Yan Shu‐mei , Liang Jie‐ying , Zeng Zhao‐lei , Ju Huai‐qiang , Xu Rui‐hua , Li Yu‐hong 
Published: February 2019

AbstractAn increasing amount of evidence suggests that high‐density lipoprotein cholesterol (HDL‐C) is related to a positive prognosis in various cancers. However, the correlation between HDL‐C and the immune signature and the prognostic role of HDL‐C in stage II/III colorectal cancer (CRC) has not been previously reported. A total of 667 CRC patients were enrolled and divided into two groups based on the lower limit of normal HDL‐C values (0.78 mmol/L). We used Kaplan‐Meier curves and the Cox regression model to analyze the prognostic role of HDL in both disease‐free survival (DFS) and overall survival (OS). Fifty‐five pairs of tumor tissues were selected according to the variation in HDL‐C levels (high or low) and the matched characterizes (ages, T stage, and N stage). Using immunohistochemistry, tumor tissues were stained with antibodies against CD3, CD8, CD163, iNOS, Forkhead box P3 (FOXP3), and CD33. We calculated the density of positively‐stained infiltrating cells in the tumor center (TC) and invasive margin (IM). We then used Spearman rank correlation to further investigate the relationship between HDL‐C levels and the immune signatures. Our results revealed that compared to patients with high HDL‐C levels, patients with low HDL‐C levels had poor 3‐year DFS (68.9% vs 83.1%, P = 0.032) and 5‐year OS rates (66.6% vs 85.3%, P = 0.002). We also identified a positive correlation between HDL‐C and CD3+, CD8+ and iNOS+ cells and a negative correlation between HDL‐C and CD163+ cells in both the TC and IM. This study reveals that a low HDL‐C level in stage II/III CRC patients predicts poor prognosis. The correlation between the HDL‐C level and immune signature in tissue specimens suggested that HDL‐C is likely to play an inhibitory role in tumor development via affecting immune responses.
Absolute Configuration Assignment from Optical Rotation Data by Means of Biphenyl Chiroptical Probes
Authors: Vergura Stefania , Scafato Patrizia , Belviso Sandra , Superchi Stefano 
Published: February 2019

AbstractA non‐empirical approach for the assignment of the absolute configuration of chiral 2‐alkyl‐substituted carboxylic acids and primary amines by [α]Dmeasurements has been developed. The method requires the conversion of the chiral acids or amines into the corresponding 4,4′‐disubstituted biphenylamides or biphenylazepines, respectively. In these derivatives a central‐to‐axial chirality transfer induces a preferred torsion in the biphenyl moiety revealed by the sign of the biphenyl A band in the ECD spectrum. By 4,4′‐substitution on the biphenyl moiety a redshift of the A band is obtained, leading to an increase of its relative contribution to optical rotation. This allows to reliably establish a direct correlation between the [α]Dsign, the biphenyl twist and, then, the substrate absolute configuration. This approach thus constitutes a really practical and reliable method to assign the absolute configuration of chiral carboxylic acids and primary amines by simple and straightforward [α]Dmeasurement, readily obtainable by a routine instrumentation like the polarimeter.
Effective computer‐assisted pronunciation training based on phone‐sensitive word recommendation
Authors: Jo Jinhyuk , Ko Song , Kim Dae‐Won , Lee Jaesung 
Published: February 2019

SummaryOwing to their autonomous nature, computer‐aided pronunciation training systems are regarded as a useful tool for pronunciation training for beginner‐level students, particularly those who feel uncomfortable having their pronunciation corrected in front of other students or who have difficulty with face‐to‐face training for other reasons. In this study, we propose a computer‐assisted pronunciation training system targeting unacceptable pronunciation due to confusion among contextual allophones, a problem that often emerges from phoneme‐based feedback provided during pronunciation training. To consider the different pronunciation of phonemes according to position, the proposed system is implemented to recommend a set of words focusing on phoneme pairs. Experimental results show that the proposed system results in the improvement of pronunciation skills through training sessions that use recommended words containing phoneme pairs that were initially pronounced incorrectly.
Parents’ experiences of childhood abuse and neglect are differentially associated with behavioral and autonomic responses to their offspring
Authors: Buisman Renate S. M. , Bakermans‐Kranenburg Marian J. , Pittner Katharina , Compier‐de Block Laura H. C. G. , van den Berg Lisa J. M. , van IJzendoorn Marinus H. , Tollenaar Marieke S. , Elzinga Bernet M. , Lindenberg Jolanda , Alink Lenneke R. A. 
Published: February 2019

AbstractAlthough childhood maltreatment has been shown to compromise adaptive parental behavior, little is known what happens in terms of physiological regulation when parents with a history of childhood maltreatment interact with their offspring. Using a sample of 229 parents (131 women), the present study examined whether childhood maltreatment experiences are associated with parents’ behavioral and autonomic responses while resolving conflict with their offspring. Self‐reported experienced child maltreatment was measured using a questionnaire assessing abuse and neglect. Parents (Mage = 52.7 years, rangeage = 26.6–88.4 years) and their offspring (Mage = 24.6 years, rangeage = 7.5–65.6 years) participated in a videotaped parent–offspring conflict interaction task. Parental warmth, negativity, and emotional support were coded. In addition, their pre‐ejection period and respiratory sinus arrhythmia were measured as indicators of underlying sympathetic and parasympathetic nervous system reactivity, respectively. Findings demonstrated that experiences of abuse and neglect were associated with behavioral and physiological responses in different ways. Separating these two types of maltreatment in research and in clinical practice might be important.
Genetic variation in Breviolum antillogorgium, a coral reef symbiont, in response to temperature and nutrients
Authors: Bayliss Shannon L. J. , Scott Zoë R. , Coffroth Mary Alice , terHorst Casey P. 
Published: February 2019

AbstractSymbionts within the family Symbiodiniaceae are important on coral reefs because they provide significant amounts of carbon to many different reef species. The breakdown of this mutualism that occurs as a result of increasingly warmer ocean temperatures is a major threat to coral reef ecosystems globally. Recombination during sexual reproduction and high rates of somatic mutation can lead to increased genetic variation within symbiont species, which may provide the fuel for natural selection and adaptation. However, few studies have asked whether such variation in functional traits exists within these symbionts. We used several genotypes of two closely related species, Breviolum antillogorgium and B. minutum, to examine variation of traits related to symbiosis in response to increases in temperature or nitrogen availability in laboratory cultures. We found significant genetic variation within and among symbiont species in chlorophyll content, photosynthetic efficiency, and growth rate. Two genotypes showed decreases in traits in response to increased temperatures predicted by climate change, but one genotype responded positively. Similarly, some genotypes within a species responded positively to high‐nitrogen environments, such as those expected within hosts or eutrophication associated with global change, while other genotypes in the same species responded negatively, suggesting context‐dependency in the strength of mutualism. Such variation in traits implies that there is potential for natural selection on symbionts in response to temperature and nutrients, which could confer an adaptive advantage to the holobiont.
Electrocatalytic Activity of Asymmetrical Cobalt Phthalocyanines in the Presence of N Doped Graphene Quantum Dots: The Push‐pull Effects of Substituents
Authors: Nkhahle Reitumetse , Sekhosana Kutloano Edward , Centane Sixolile , Nyokong Tebello 
Published: February 2019

AbstractA series of Co phthalocyanine (CoPc) derivatives and their respective nitrogen doped graphene quantum dot conjugates were used as catalysts towards the electrooxidation of hydrazine. Using a glassy carbon electrode as a support for the electrocatalysts, through cyclic voltammetry and chronoamperometry, the effects of combining the CoPcs with the nitrogen doped graphene quantum dots (NGQDs) were studied. The general observations made were that the NGQDs improve the catalytic activity of the CoPcs in both the π‐π stacked and covalently linked conjugates by increasing the sensitivities and lowering the limits of detection with values as low as 0.43 μM being recorded.
Optimized temporal sampling designs of the Weibull growth curve with extensions to the von Bertalanffy model
Authors: Swintek J. , Etterson M. , Flynn K. , Johnson R. 
Published: February 2019

AbstractWe describe designs for the temporal aspect of sampling in an experiment that estimates the population mean growth of an organism that can be modeled using a Weibull or von Bertalanffy growth curve. First, the properties of the Weibull growth curve are explained. Next, using the shape parameter (v), the Weibull growth curve can be categorized into two shape categories: sigmoid and saturation. D‐optimization and shape classification are used to determine the optimal sampling occasions and the effect of a sampling schedule on the precision of the size estimates. Finally, the results are used to recommend a generalized sampling design to best determine the shape and size of a growth curve.
Numerical simulation of oxy‐fuel combustion characteristics in a 200 MWe coal‐fired boiler
Authors: Wu Haibo , Mao Yu , Liu Zhaohui , Zhang Yi , Liao Haiyan 
Published: February 2019

AbstractOxy‐fuel combustion in coal‐fired plants has become one of the most promising technologies for carbon capture and storage (CCS). Because of the obvious difference between the oxy‐fuel combustion medium (O2/CO2) and air in the atmosphere (O2/N2), the characteristics of combustion, heat transfer, etc., under oxy‐fuel combustion have changed greatly from those under air combustion. In this paper, computational fluid dynamics (CFD) simulation was used to investigate pulverized coal combustion in a 200 MWe tangentially fired oxy‐fuel combustion boiler. Improved models for the gas radiative properties and chemical reaction mechanisms were incorporated into the CFD code. Both conventional air‐fired and oxy‐fuel combustion were operated. Different flue gas recycling patterns (dry recycling and wet recycling) were also investigated. The temperature distribution in the furnace, the temperature field, and the CO concentration field in each scheme were analyzed, this being relevant to the design of oxy‐fuel combustion boilers. It was found that combustion could form a good tangential circle and stable temperature field in the furnace either under air‐fired or oxy‐fule combustion conditions. The temperature under oxy‐fuel combustion was lower than with air combustion. The burnout rate under the air condition was lower than that with the oxy‐fuel combustion condition. With oxy‐fuel combustion, it is necessary to pay special attention to the slagging tendency of the primary combustion zone in the furnace. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Label‐free optical projection tomography for quantitative three‐dimensional anatomy of mouse embryo
Authors: Ban Sungbea , Cho Nam Hyun , Min Eunjung , Bae Jung Kweon , Ahn Yujin , Shin Sungwon , Park Soo‐Ah , Lee Yoonsung , Jung Woonggyu 
Published: February 2019

AbstractRecent progress in three‐dimensional optical imaging techniques allows visualization of many comprehensive biological specimens. Optical clearing methods provide volumetric and quantitative information by overcoming the limited depth of light due to scattering. However, current imaging technologies mostly rely on the synthetic or genetic fluorescent labels, thus limits its application to whole‐body visualization of generic mouse models. Here, we report a label‐free optical projection tomography (LF‐OPT) technique for quantitative whole mouse embryo imaging. LF‐OPT is based on the attenuation contrast of light rather than fluorescence, and it utilizes projection imaging technique similar to computed tomography for visualizing the volumetric structure. We demonstrate this with a collection of mouse embryo morphologies in different stages using LF‐OPT. Additionally, we extract quantitative organ information applicable toward high‐throughput phenotype screening. Our results indicate that LF‐OPT can provide multi‐scale morphological information in various tissues including bone, which can be difficult in conventional optical imaging technique.
Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases
Authors: Whitney Daniel G , Alford Andrea I , Devlin Maureen J , Caird Michelle S , Hurvitz Edward A , Peterson Mark D 
Published: February 2019

ABSTRACT

Individuals with cerebral palsy (CP) have an increased risk of fracture throughout their lifespan based on an underdeveloped musculoskeletal system, excess body fat, diminished mechanical loading, and early development of noncommunicable diseases. However, the epidemiology of fracture among adults with CP is unknown. The purpose of this cross-sectional study was to determine the prevalence of fracture among a large sample of privately insured adults with CP, as compared with adults without CP. Data were from the Optum Clinformatics Data Mart (Eden Prairie, MN, USA), a deidentified nationwide claims database of beneficiaries from a single private payer. Diagnostic codes were used to identify 18- to 64-year-old beneficiaries with and without CP and any fracture that consisted of osteoporotic pathological fracture as well as any type of fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions. The prevalence of any fracture was compared between adults with (n = 5,555) and without (n = 5.5 million) CP. Multivariable logistic regression was performed with all-cause fracture as the outcome and CP group as the primary exposure. Adults with CP had a higher prevalence of all-cause fracture (6.3% and 2.7%, respectively) and fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions compared with adults without CP (all p &lt; 0.01). After adjusting for sociodemographic and socioeconomic variables, adults with CP had higher odds of all-cause fracture compared with adults without CP (OR 2.5; 95% CI, 2.2 to 2.7). After further adjusting for cardiometabolic diseases, adults with CP had higher odds of all-cause fracture compared with adults without CP (OR 2.2; 95% CI, 2.0 to 2.5). After further adjusting for osteoporosis, adults with CP still had higher odds of all-cause fracture compared with adults without CP (OR 2.0; 95% CI, 1.8 to 2.2). These findings suggest that young and middle-aged adults with CP have an elevated prevalence of all-cause fracture compared with adults without CP, which was present even after accounting for cardiometabolic diseases and osteoporosis. © 2019 American Society for Bone and Mineral Research.
Metabolism, Excretion, and Pharmacokinetics of [14C]‐Cefiderocol (S‐649266), a Siderophore Cephalosporin, in Healthy Subjects Following Intravenous Administration
Authors: Miyazaki Shiro , Katsube Takayuki , Shen Helen , Tomek Charles , Narukawa Yukitoshi 
Published: February 2019

AbstractThe objectives of this study were to characterize the concentration‐time profiles of total radioactivity equivalent and unchanged cefiderocol, the route(s) of elimination and mass balance, and safety of cefiderocol after intravenous administration of a single 1000‐mg (100 μCi) dose of [14C]‐cefiderocol as a 1‐hour infusion in healthy adult male subjects. Unchanged cefiderocol accounted for the majority of total radioactivity in plasma, and the partitioning of total radioactivity into red blood cells was negligible. The recovery of total radioactivity was complete in all subjects within 120 hours after initiation of the infusion (101.5% of the administered dose). Cefiderocol‐related material was primarily excreted into urine, with 98.7% of the administered dose of [14C]‐cefiderocol excreted as total radioactivity into urine and negligible excretion into feces. Based on the results of metabolite profiling, cefiderocol accounted for 92.3% of area under the concentration‐time curve of total radioactivity in plasma and accounted for 90.6% of the administered dose excreted into urine. Metabolism was a minor route of elimination for cefiderocol. Cefiderocol was generally safe and well tolerated in healthy adult male subjects. In conclusion, unchanged cefiderocol represents the majority of total radioactivity in plasma. Cefiderocol is primarily excreted as unchanged drug into urine. This study indicates that cefiderocol and drug‐related material did not remain in the body.
Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?
Authors: Ram Daniel R , Manickam Cordelia , Lucar Olivier , Shah Spandan V , Reeves R Keith 
Published: February 2019

Abstract
NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency virus (SIV)-infected cells. Promising developments include recent reports that CAR NK cells are capable of targeted responses while producing less off-target and toxic side effects than are associated with CAR T cell therapies. Further, CAR NK cells derived from inducible pluripotent stem cells or cell lines may allow for more rapid “off-the-shelf” access. Other work investigating the IL-15 superagonist ALT-803 (now N803) may also provide a recourse for enhancing NK cell responses in the context of the immunosuppressive and inflammatory environment of chronic HIV/SIV infections, leading to enhanced control of viremia. With a broader acceptance of research supporting adaptive functions in NK cells it is likely that novel immunotherapeutics and vaccine modalities will aim to generate virus-specific memory NK cells. In doing so, better targeted NK cell responses against virus-infected cells may usher in a new era of NK cell-tuned immune therapy.
Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4‐year cohort study
Authors: Iwasaki Masanori , Taylor George W. , Sato Misuzu , Minagawa Kumiko , Ansai Toshihiro , Yoshihara Akihiro 
Published: February 2019

AbstractBackgroundPeople with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse.MethodsThis 4‐year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community‐dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow‐up examinations. Multilevel logistic regression models estimated the tooth‐specific risk of AL progression (≥1 site exhibiting a ≥3 mm increase in AL) with baseline CKD (eGFR < 60 mL/min/1.73 m2) as the principal exposure.ResultsAt baseline, 27.8% of the study population (108/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15–2.60).ConclusionsThe results suggest that CKD increases the risk of periodontal disease progression in older community‐dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.