bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENTREVISTA COM MOISÉS DIAS DE OLIVEIRA E MÔNICA NOGUEIRA: O CERRADO É DIVERSO! SOBRE OS TRADICIONAIS MODOS DE VIDA, NÃO É QUE ELES PRECISEM SER LEGISLADOS, ELES TÊM DE SER É RESPEITADOS*
Authors: Gollo Alexandre Magno Lopes , Amanajás Edmir 
Published: November 2024

A conversa entre Moisés Dias de Oliveira, Mônica Nogueira, Edmir Amanajás e Alexandre Gollo foi realizada em duas etapas, através da plataforma Googlemeet; a primeira em 20/12/2023, quando Moisés sugeriu o convite à Mônica, professora e pesquisadora parceira do movimento geraizeiro no norte de Minas Gerais, e que fora sua orientadora na pesquisa sobre a autodefinição identitária e territorial no norte de Minas Gerais (Oliveira, 2017), na dissertação concebida no Curso de Mestrado profissional em Sustentabilidade junto a Povos e Terras Tradicionais, no Centro de Desenvolvimento Sustentável, na Universidade Nacional de Brasília (UNB). A segunda rodada ocorreu no dia 07/03/2024, já com os dois interpretantes das territorialidades e dos conflitos que as comunidades geraizeiras vivenciam. Para além de facilitar compreender o que é, e como se constrói, uma identidade coletiva, a partir da convivência com um bioma específico, esta síntese propicia deparar-se com os atuais dilemas que perpassam os temas das juventudes, da comunicação, da conexão com as realidades vividas e com as formas de resistência que têm sido acionadas pelas representações geraizeiras para enfrentar um conjunto também dinâmico e diversificado de fronteiras e de ameaças aos territórios e ao modo de vida geraizeiro. O pensamento em propiciar ao leitor uma oportunidade de compreensão sobre o que é ser geraizeiro, ou parte constituinte de um povo, ou comunidade tradicional, nos levou ao momento sublime em que nossos interpretantes se apresentam, uma pelo outro, e vice-versa. Boa leitura!
Validacija Skale percipiranog narcisoidnog roditeljstva
Authors: Borović Luka , Džamonja Ignjatović Tamara 
Published: November 2024

Termin narcisoidno roditeljstvo opisuje odnos roditelja i djeteta u kome dominiraju potrebe roditelja, uz zanemarivanje potreba djeteta i sputavanje razvoja njegove autonomije. Dijete je sredstvo zadovoljenja potreba i ciljeva roditelja bez obzira na njegove autentične želje i emocije. Za potrebe istraživanja ovog fenomena je konstruisana Skala percipiranog narcisoidnog roditeljstva, sa paralelnim formama za majku i oca. Skala obuhvata indikatore psihička kontrola, uslovno vrijednovanje, postavljanje visokih standarda i roditeljsko favorizovanje. Uzorak se sastojao od 230 mladih, starosti od 18 do 30 godina (M = 22, SD = 3.00), većinom ženskog pola (83.91%). Njih 36.52% izvještava da se do sada obraćalo za psihološku pomoć. Eksplorativna faktorska analiza skale percepcije majčinog i očevog ponašanja pokazuje da je u oba slučaja optimalno rješenje jednofaktorsko kada se isključe stavke koje se odnose na percipirano roditeljsko favorizovanje. I skala percepcije majke (ω = .98) i skala percepcije oca (ω = .97) ispoljavaju visok stepen interne konzistentnosti. Grupa mladih koja je bila uključena u psihološko savjetovanje ili terapiju postiže značajno više skorove na obje forme skale u odnosu na mlade koji nikada nisu tražili stručnu pomoć, što je nalaz u prilog konvergentne validnosti skale. Konstruisana skala ima optimalne metrijske karakteristike i preporučuje se njeno korišćenje prilikom identifikovanja ovog obrasca roditeljstva u praksi. Ograničenja su retrospektivna priroda tvrdnji i nužnost uvida u problematičnost ponašanja roditelja.
Prevalence of Camel Mange and Associated Risk Factors in The Banadir Region, Somalia
Authors: Mohamed Moktar Omar Sheikh , Mio Jeilani Buzuri , Abdullahi Abdullahi Abdirashid , Adow Ilyaas Abukar  , Derow Mahad Abdinur 
Published: November 2024

Background: Camel mange, a highly infectious and itchy condition brought on by Sarcoptes scabiei var. cameli, can be spread through direct and indirect contact. It is one of the most significant parasitic diseases affecting camels, severely impacting their productivity and health, with substantial economic consequences. Purpose: Assessing the prevalence of camel mange mites and identifying potential risk factors. Method: This cross-sectional study was carried out between June 2023 and February 2024 in the Benadir region of Somalia. A total of 384 camels were randomly selected for skin scrapings, with samples from suspected lesions being microscopically examined. Results: Of these, 82 camels (21%) were infested with mange mites, with Sarcoptes scabiei var. cameli identified as the only mite species. The research uncovered that the condition of the body, the size of the herd, and age substantially influenced the prevalence of mange mites (p<0.05), while district, sex, and age had no significant effect on infestation rate (p>0.05). Conclusion: The results suggest that mange mite infestations in the camel populations in the Benadir region negatively affect their health and productivity. Therefore, there is an urgent need to improve management practices and conduct further research and control measures to mitigate the effects of mange mite infestations on camel husbandry.
Discover the Driving Forces behind Purchase Intention in Indonesia’s Beauty Industry
Authors: Aulia Affiana , Oktariani Theresia Omiwa 
Published: November 2024

Background: The beauty sector is expanding significantly in Indonesia. As Indonesia's domestic beauty sector grows, consumers must select goods that meet their demands and are licensed by Indonesian Food and Drug Authority (BPOM). It is crucial for beauty sector companies in Indonesia to identify the drivers that influence consumer intention to purchase beauty products.
Objective: This study aims to examine the impact of social media marketing activity, emotional branding, price perception, and online customer review variables on purchase intention.
Method: A quantitative research design was utilized in this study with 100 respondents who provided information online regarding their intention to purchase products in the Indonesian beauty industry.
Results: Price perception and social media marketing activity has been shown in this study to impact purchase intention in the Indonesian beauty industry. Emotional branding and online customer reviews, on the other hand, don't affect people's intention to buy in the Indonesian beauty business.
Conclusion: This research highlights the factors that influence purchase intention in the Indonesian beauty industry. The findings of this study indicate that social media marketing activity and price perception are significant drivers of consumer intention to purchase beauty products.

Keywords: Emotional Branding; Online Customer Review; Price Perception; Purchase Intention; Social Media Marketing Activity
Multi-Product Quantity Discount
Authors: Liu Zuofeng 
Published: November 2024

Abstract

Multi-product quantity discount (MPQD) is the quantity discount for purchasing items from multiple products. To launch MPQD for products with different MPQD strategies, sellers always need to manually unify the MPQD strategies of the products in current practice. The inefficient manual approach often cannot reasonably achieve the purpose, which greatly limits the development of MPQD business. Can we develop a general algorithm to take over the manual work to reasonably calculate the discounts for purchased products while keeping the products’ MPQD strategies unchanged? This is the goal proposed and achieved in this paper for the first time.
Starting from revealing the underlying logic of MPQD, this paper constructs a theoretical framework including the basic assumptions, concepts, and principles, and based on the theoretical framework completes the development of an MPQD algorithm (MPQDA for short).
With the support of the MPQDA which breaks down the barriers to launching MPQD, sellers will be able to launch large-scale automated and complex MPQD businesses, and the manifestations of MPQD will be greatly enriched. In addition, as a convenient tool for automating and accurately coordinating the benefits of multiple parties, the MPQDA can be widely and persistently applied in the areas where the relevant business can be mapped to MPQD, such as in fission marketing, which will give rise to new business models.
Human iPSC-derived pericyte-like cells carrying the LRRK2 mutation induce a reactive phenotype and alter migration
Authors: Peltonen Sanni , Sonninen Tuuli-Maria , Niskanen Jonna , Koistinaho Jari , Ruponen Marika , Lehtonen Šárka 
Published: November 2024

Abstract

BACKGROUND
Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are impaired in Parkinson’s disease. Still, there is a lack of studies on the impact of pericytes on neurodegenerative diseases, and their involvement in the pathology of Parkinson’s disease is unclear. Our objective was to investigate the molecular and functional differences between healthy pericytes and pericytes harboring the LRRK2 G2019S mutation, a prevalent mutation linked to Parkinson’s disease.
METHODS
This study utilized pericyte-like cells derived from induced pluripotent stem cells obtained from Parkinson’s disease patients with the LRRK2 G2019S mutation and healthy individuals. We examined the gene expression profiles of these cells and assessed how the modifications impact their functionality.
RESULTS
We have demonstrated differences in the expression of genes related to inflammation and angiogenesis. Furthermore, we have observed that proinflammatory stimuli modify migration speed in Parkinson’s disease pericyte-like cells and enhance the secretion of inflammatory mediators, such as soluble VCAM-1 and MCP-1.
CONCLUSIONS
In summary, our findings support the notion that pericytes play a role in the inflammatory and vascular changes observed in Parkinson’s disease. Further investigation of pericytes could provide valuable insight into the pathophysiology of Parkinson’s disease.
The Unique Association Between Estimated Pulse Wave Velocity And The Prevalence Of Diabetic Kidney Disease: A Cross-Sectional Study
Authors: Wei Shuwu , Pan Xinyu , Xiao Yao , Wei Junping 
Published: November 2024

Abstract

Objective
Arteriosclerosis is the pathological basis for Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD. Our research represents the first embark to explore the relationship between ePWV and DKD.
Methods
In this cross-sectional analysis, we collected ePWV data from a cohort of 4,296 hospitalized Chinese patients. Multivariable-adjusted logistic regression models and restricted cubic spline (RCS) analysis were employed to examine the relationship between eGDR and the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m².
Results
After adjusting for confounding factors, each unit increase in ePWV was associated with a 23%, 21% and 25% increase in the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m² in T2DM participants, respectively. A J-shaped relationship was observed between ePWV and the prevalence of DKD and eGFR < 60 mL/min per 1.73 m², and a linear association between ePWV and the prevalence of UACR ≥ 30 mg/g.
Conclusion
ePWV is independently positively correlated with the prevalence of DKD. Integrating ePWV into routine clinical evaluations enable timely interventions and personalized management approaches.
Kawasaki disease with cardiac involvement revealed by acute pancreatitis in an adult: A rare case report.
Authors: BARAKAT Leila , HABOUB Meryem , MHABER Safaa , ECHCHILALI Khadija , MOUDATIR Mina , DRIGHIL Abdenasser , AROUS Salim , BENOUNA Mohamed Ghali , HABBAL Rachida , KABLI Hassan EL 
Published: November 2024

Abstract

Background: Kawasaki disease (KD) is a rare systemic inflammatory disease primarily affecting children under 5 years of age, with very few cases reported in adults. This condition is characterized by potential coronary involvement, including aneurysms and gastrointestinal manifestations, such as pancreatitis.Case Presentation: A 21-year-old man presented with a febrile rash, fever, conjunctivitis, and acute pancreatitis. Imaging revealed coronary artery aneurysms. Treatment with intravenous immunoglobulins, aspirin, and corticosteroids led to significant clinical improvement.Conclusions: This case underscores the rare occurrence of Kawasaki disease in adults, particularly with both pancreatic and coronary artery involvement. The effective use of immunoglobulins and corticosteroids highlights the importance of early diagnosis and treatment in managing this rare condition in adults.
SMOC1 colocalizes with Alzheimer’s disease neuropathology and delays Aβ aggregation
Authors: Balcomb Kaleah , Johnston Caitlin , Kavanagh Tomas , Leitner Dominique , Schneider Julie , Halliday Glenda , Wisniewski Thomas , Sunde Margaret , Drummond Eleanor 
Published: November 2024

Abstract

SMOC1 has emerged as one of the most significant and consistent new biomarkers of early Alzheimer’s disease (AD). Recent studies show that SMOC1 is one of the earliest changing proteins in AD, with levels in the cerebrospinal fluid increasing many years before symptom onset. Despite this clear association with disease, little is known about the role of SMOC1 in AD or its function in the brain. Therefore, the aim of this study was to examine the distribution of SMOC1 in human AD brain tissue and to determine if SMOC1 influenced amyloid beta (Aβ) aggregation. The distribution of SMOC1 in human brain tissue was assessed in 3 brain regions (temporal cortex, hippocampus, frontal cortex) using immunohistochemistry in a cohort of 73 cases encompassing advanced AD, mild cognitive impairment (MCI), preclinical AD and cognitively normal controls. The Aβ- and phosphorylated tau-interaction with SMOC1 was assessed in control, MCI and advanced AD human brain tissue using co-immunoprecipitation, and the influence of SMOC1 on Aβ aggregation kinetics was assessed using Thioflavin T assays and electron microscopy. SMOC1 strongly colocalized with a subpopulation of amyloid plaques in AD (43.8±2.4%), MCI (32.8±5.4%) and preclinical AD (28.3±6.4%). SMOC1 levels in the brain strongly correlated with plaque load, irrespective of disease stage. SMOC1 also colocalized with a subpopulation of phosphorylated tau aggregates in AD (9.6±2.6%). Co-immunoprecipitation studies showed that SMOC1 strongly interacted with Aβ in human MCI and AD brain tissue and with phosphorylated tau in human AD brain tissue. Thioflavin T aggregation assays showed that SMOC1 significantly delayed Aβ aggregation in a dose-dependent manner, and electron microscopy confirmed that the Aβ fibrils generated in the presence of SMOC1 had an altered morphology. Overall, our results emphasize the importance of SMOC1 in the onset and progression of AD and suggest that SMOC1 may influence pathology development in AD.
Genome-wide DNA methylation analysis of hippocampal tissue in a murine model of Attention Deficit-Hyperactivity Disorder
Authors: Vidal Rodrigo , Lopez Ignacio , Ugarte Gonzalo , Contreras Darwin , Piña Ricardo , Godoy Felipe , Rozas Carlos , Rubio David , Mantellero Carola , Constandil Luis , Escobar Jorge , Morales Bernardo 
Published: November 2024

Abstract

Background.Attention Deficit-Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with a prevalence around 5% in children and adolescents and 2.5% in adults. Recent reports using GWAS approaches have identified several genetic risk loci for this disorder. However, the epigenetic influence of extrinsic factors during pregnancy or the exposure to environmental factors during childhood, on the onset of the disorder remains unclear. This question has been addressed mainly by analyzing fluid samples such as blood and saliva taken from ADHD patients or by postmortem analysis. The aim of this study was to determine differential patterns in DNA methylation in hippocampal samples using a murine model of ADHD to identify putative epigenetic biomarkers.Methods.We analyzed the genome-wide pattern of differentially methylated CpG sites identified after bisulfite conversion using the Illumina Infinium Mouse Methylation BeadChip in fresh hippocampal tissue samples from the prenatal nicotine exposure (PNE) mouse model of ADHD and control animals.Results.Our analysis revealed 218 DMPs including genes with the highest difference between beta-values in PNE and control samples associated with growth factors signaling, such as adhesion G protein-coupled receptor B2 (ADGRB2), leukemia inhibitory factor receptor (LIFR) and erb-b2 receptor tyrosine kinase 3 (ERBB3) involved in synaptogenesis, proliferation, and differentiation of neural stem cells. The functional gene enrichment analysis of DMPs revealed the nervous system development as the biological process with highest enrichment factor. In addition, the analysis of 113 DMR revealed several loci associated with the positive regulation of Hippo signaling in PNE samples. Notably, the SPTBN2 gene emerged as DMR in our analysis has also been described as a DMP in blood samples of children with ADHD, and NGR3 (a ligand of the ERBB3 receptor) has been described as a DMR in postmortem analysis of human brain samples.Conclusions.Our results revealing a DMP previously associated with ADHD support the validation of the PNE murine model of ADHD allowing further in vivo and ex vivo experiments required to characterize the molecular mechanisms underlying the onset and persistence of the disorder. In addition, the identification of new DMPs and DMRs in the hippocampal samples of PNE animals will contribute to evaluate the epigenetic status in human samples and the identification of new putative epigenetic markers of the disorder.
Neutrophil Extracellular Traps Regulate the Pathogenesis of Pulmonary Fibrosis by Inducing Epithelial-Mesenchymal Transition
Authors: Shi Wenchao , Shang Yu , Li Zhiheng , Yu Yao , Shi Si , Liu Lijie , Luo Yakun , Chen Hong , Jin Shoude 
Published: November 2024

Abstract

Background
Neutrophil extracellular traps released after neutrophil activation are associated with various diseases and redefine the biological functions of neutrophils. Studies have reported a significant increase in the number of neutrophils in the bronchoalveolar lavage fluid and lung tissue of patients with idiopathic pulmonary disease. However,neutrophil-mediated pathogenic mechanisms of idiopathic pulmonary disease remain unclear.
Methods
The biological functions of neutrophil extracellular traps were evaluated using proliferation,wound healing and transwell assays.The expression of different fibrosis factors was detected using western blot and immunohistochemistry staining in vivo and in vitro.
Results
Neutrophil extracellular traps promote the proliferation and migration of A549 and BEAS-2B cells by inducing epithelial-mesenchymal transition. Based on our current transcriptome RNA sequencing analysis, ELANE (encoding the neutrophil elastase gene) was a major differentially expressed gene, and the Wnt signaling pathway was the major pathway as demonstrated through Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Neutrophil extracellular traps, through their protease neutrophil elastase interacting with β-catenin, trigger changes in the expression of markers of epithelial-mesenchymal transition, including E-cadherin and vimentin. Additionally, Sivelestat·Na disrupts the stability of neutrophil extracellular traps structures by inhibiting the activity of neutrophil elastase, thereby suppressing neutrophil extracellular traps-induced epithelial-mesenchymal transition, and alleviating acute lung injury and pulmonary fibrosis induced by bleomycin in mice.
Conclusions
Our results suggest that the neutrophil extracellular traps/Wnt axis promotes the progression of epithelial-mesenchymal transition and the progression of pulmonary fibrosis,recommending it a target for new therapeutic strategies for early-stage pulmonary fibrosis.
Comparative Analysis of the Optic Nerve Microvasculature Between Different Optic Disc Phenotypes of Normal-Tension Glaucoma Patients
Authors: Song Min Kyung , Lee Yunhan , Shin Joong Won , Lee Jin Yeong , Hong Ji Wook , Kook Michael S. 
Published: November 2024

Abstract

PURPOSE: To determine whether the optic nerve head (ONH) and parapapillary choroidal vessel density (VD), measured by optical coherence tomography angiography (OCTA), differ between two common optic disc phenotypes (ODPs) in normal-tension glaucoma (NTG).
DESIGN: A retrospective case-control study.
METHODS: This cross-sectional study analyzed 100 NTG patients with visual field (VF) loss confined to a single hemifield (50 eyes with focal ischemic [FI] ODP and 50 eyes with myopic glaucomatous [MG] ODP, matched for age [≤ 10 years] and visual field [VF] severity [mean deviation ≤ 1 dB]) as well as 50 healthy eyes. Using OCTA, ONH VD (ONH-VD) was evaluated on a 4.5 x 4.5 mm ONH en-face image using the whole-signal mode. The parapapillary choroidal VD (pCVD) was measured on en-face choroidal layer image within the entire β-parapapillary atrophy (β-PPA) zone using imageJ software. The ONH-VD and pCVD were compared among the three groups. The relationships between ONH-VD and pCVD outcomes and various clinical variables were assessed.
RESULTS: The average ONH-VD and pCVD were significantly lower in eyes with MG ODPs than those with FI ODPs (56.9% vs. 60.4%, 67.1% vs. 71.8%; both P < 0.05). Multivariable linear regression analysis indicated that MG ODP, lower peripapillary retinal nerve fiber layer thickness and VD in the hemiretina, corresponding to hemifield VF loss, in addition to the presence of choroidal microvasculature dropout, were significantly associated with lower ONH-VD and pCVD (P < 0.05).
CONCLUSIONS: The OCTA-measured ONH-VD and pCVD are significantly lower in eyes with MG ODPs rather than FI ODPs. MG ODP is independently associated with lower ONH-VD and pCVD in NTG eyes.
Prognostic Impact and Therapeutic Potential of CDC20 in Cervical Cancer: Insights from Clinical and Experimental Analyses
Authors: Xian Feng , Zhu Qi , Zhang Guojun , Bie Jun , Xu Guohui 
Published: November 2024

Abstract

CDC20 has been identified as an oncogene involved in the development and prognosis of various cancers, yet its role in cervical cancer remains unclear. This study aimed to evaluate CDC20 expression in cervical cancer tissues and its clinical significance. We conducted a retrospective analysis of 249 cervical cancer patients diagnosed at Nanchong Central Hospital from January to December 2022. Immunohistochemistry was used to assess CDC20 expression, and statistical methods compared clinicopathological characteristics. Survival analysis employed the Kaplan-Meier method, and Cox regression identified survival risk factors. Additionally, siRNA was used to knock down CDC20 in HeLa cells to examine its effects on proliferation, invasion, and migration. Results indicated that CDC20 expression was significantly higher in cervical cancer tissues (61.85%) compared to adjacent normal tissues (7.5%) (p < 0.05). High CDC20 expression was associated with poorer overall survival, particularly in specific subgroups (p < 0.05) and identified as an independent risk factor (p < 0.05). Silencing CDC20 inhibited cancer cell proliferation and invasion, while xenograft models demonstrated reduced tumor growth with CDC20 inhibition (p < 0.01). CDC20 may serve as a valuable prognostic biomarker and therapeutic target for cervical cancer.