bluuebunny/crossref_metadata_2025_split huggingface dataset:
AYURVEDA PERSPECTIVE ON MOOTRASHMARI AND ITS MANAGEMENT: AN LITERATURE BASED REVIEW
Authors: Patel Diwakar , Kulshrestha Deepak 
Published: September 2018

The formation of stone is one of the common problems of urinary system and as per modern science only few medicines are available for such condition along with surgery. It is second most common disease of urinary tract with high recurrence rate. The common symptoms of ureter culculi are pain, haematuria, burning micturiton, dysurea, tenderness and sometimes fever. Ayurveda described Mootrashmari as urinary calculus disease of Mutravaha Srotas and considered as Asthamahagada. Ayurveda described various treatment approaches for the management of disease; use of herbs, ayurveda formulation and Kshara, etc. this article presented summarative review on Mootrashmari.
Keywords: Ayurveda, Ashmari, Mutravaha Srotas, Mootrashmari
Ayurveda Literary Research Study on Some Important Aspects of Srotas
Authors: Chouhan Pradeep Kumar 
Published: September 2018

The ancient medical science of India; Ayurveda considered Srotas as an important structural and functions entity of human body. The Hira, Antreshu, Gavinyau, Dhamani, Srotyah, Panth, Khani, Srawanti, Nadi and Dwar are considered as Srotas or they together form Srotas. Akashaa Mahabhut is mainly involves in the constitution of Srotas. Srotas play significant role in the circulation and transportation of various materials. Different studies have been conducted on Srotas, but still there is more to explore in this regards; considering this fact present investigation was planned to conduct more deep study related to ayurveda perspective of Srotas. The article presented critical study of Srotas with special reference to microcirculation in a view to explore all dimensions of micro channels. The study described various concepts related to nature, structure, functions and development of the Srotas.
Keywords: Ayurveda, Srotas, micro channels, transportation.
Effect of Eclipta alba and Ocimum sanctum on haloperidol induced parkinsonism
Authors: Chahal Harmel Singh , Sharma Shailendra 
Published: September 2018

The aim of the study is protective effect of compound Eclipta alba and Ocimum sanctum on Parkinsonism induced mice by haloperidol injection. Parkinsonism is neurodegenerative disease due to the deficiency of dopamine in brain. The pathological hallmark of Parkinson’s disease in the cell loss within substantia nigra pars compacta (SNpc) region and the disease is charactrised by bradykinesia, rigidity, postural instability, orofacial dyskinesia, muscular stiffness and tremor1. Mice were injected 1mg/kg haloperidol and then treated with test and standard substance for 15 days. The impairment in catatonia in mice were tested using catatonic activity. Biochemical analysis of brain homogenate was performed so ass to assess brain Thiobarbituric acid reactive substance (TBARS) level and reduced glutathione (GSH) and TNF-α level were measured to assess total oxidative stress. EA 300mg/kg and OS 400mg/kg show slightly change in catatonic activity in mice while EA 600mg/kg and 800mg/kg significantly change in catatonic activity. Furthermore, Eclipta alba and Ocimum sanctum prevent the haloperidol induced changes in the level of brain TBARS, GSH and TNF-α. From the results we conclude that Eclipta alba and Ocimum sanctum has protective action against impairment in catatonic activity and pathological damage due to oxidative stress induced by intraperitoneally injection of haloperidol in mice.
Keywords: Eclipta alba, Ocimum Sanctum, Parkinsonism, Anti-oxidant.
In-vivo Evaluation of the Wound Healing Activity of the Sesamum Indicum L. Seed Extract in Novel Ethosomal Vesicular System
Authors: Somwanshi Sachin B , Hiremath Shivanand N 
Published: September 2018

Aim: To establish the wound healing activity of Sesamum indicum L. of seed extract in novel ethosomal vesicles. Methods: The ethosomal vesicles were formulated with prepared seed extract of Sesamum indicum L. by solvent evaporation method and characterized it. The optimized ethosomal vesicles then incorporated into gel base for further in vivo study in wistar rat. The evaluation of the wound healing activity was performed by using two models i.e. incision and excision models. In excision model percentage wound contraction and period of epithelialization were established for both the extracts. In incision model the parameter which was carried out was breaking strength of wounded skin. Results: The results revealed that the percentage wound contraction, period of epithelialization in excision model was enhanced than that of other groups and tensile strength of skin in incision model was similar to that of standard treated group.
Keywords: Sesamum indicum L., Wound Healing, Ethosomal gel.
INFLUENCE OF PROCESSING PARAMETERS ON RHEOLOGICAL BEHAVIOR OF BENTONITE-BASED PICKERING EMULSION
Authors: TOUZOUIRT Saida , KESSAL Fetta , BELAIDI Chanez , BOULHALFA Dihia 
Published: September 2018

The aim of this work is to study the impact of processing parameters on the rheological properties of Pickering emulsions containing bentonite particles, CTAB, NaCl and soybean oil. Emulsification experiments were performed using mixing and homogenization at different speeds for 10 minutes. The effects of stirring speed and homogenization were investigated to determine the best conditions for producing a suitable Pickering emulsion for the intended application. In order to assess the influence of processing parameters on the Pickering emulsion rheological behavior average droplet size was measured and rheological tests were performed on all the emulsions samples. The rheological behavior of these emulsions is modeled by Casson's law. Results show that the stirring speed first decreases the average size of the droplets, and then an effect on the initial viscosity is observed. Increasing the stirring speed increases the values of the initial viscosity in contrast to the infinite viscosity which is influenced by the homogenization speed. On the other hand, these processing parameters significantly affect the values of the yield strength.
Keywords: stirring speed, speed homogenization, rheological properties, Pickering emulsion.
FORMULATION AND EVALUATION OF SUMATRIPTAN IMMEDIATE RELEASE TABLETS
Authors: Munija P , Srikanth G 
Published: September 2018

The rationale of this investigation is to design an immediate release oral dosage of Sumatriptan succinate by using microcrystalline cellulose as filler, camphor and menthol as subliming agents by direct compression method .The basic objective of this dissertation is to develop an orodispersible tablet of sumatriptan succinate used in anti-migraine with an aim of reduces the lag time and providing faster onset of action to relief the acute migraine effect immediately. Disintegrates and disperses in oral cavity within 30 seconds without the need of drinking water. Has pleasant mouth feel and there is no after taste or grittiness. Successfully discriminates the ability of three superdisintegrants to promote drug dissolution and proposes a model formulation for disintegrants performance testing and quality control purposes. The formulation F6 containing 8% of CCS and 10% of menthol showed disintegration time of 18seconds after drying. Menthol as subliming agent was found to be most effective of all other subliming agents as it had showed drastic effect on the drug release.
Keywords: Sumatriptan succinate, sublimation, menthol, anti-migraine
GASTROPROTECTIVE NSAIDs
Authors: Shahnaz Mohammad , Kaur Parminder , Prasad DN 
Published: September 2018

NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic acid derivatives) with some antioxidants can be synthesized by esterification with various antioxidants of natural origin. The conjugates that show the retention or potentiating of anti-inflammatory activity with reduced ulcerogenic side effect could be potential gastroprotective co-drugs of NSAIDs.
Keyboards: NSAIDs, Gastroprotective, ROS, Natural antioxidants, Conjugates, Ulcerogenic
ASSESSMENT OF CLINICAL PROFILE AND TREATMENT CHART REVIEW FOR ALCOHOLIC LIVER DISEASE (ALD) PATIENTS: A PROSPECTIVE AND OBSERVATIONAL STUDY
Authors: Biradar Siddaruda Malleshappa , Gelada Dhanavanti , Mounika MV , Meghana P , Bharathi M , Ambali Anand P. , Mallinath P , Vinod M , Kalyane NV 
Published: September 2018

Background/Aim: Alcohol remains one of most common cause of liver disease in India, hence the present study was undertaken to assess the clinical profile and treatment chart review of alcoholic liver disease (ALD) patients.
Materials and Methods: Hospital based prospective and observational study was carried out for a period of nine months in a tertiary care hospital of south India. All the patients of either gender diagnosed with ALD were enrolled in the study and patient consent was taken, the data related to the patients of ALD were documented in a structured patient data collection form and analyzed carefully.
Results: ALD was mainly affected in male with age group of 41-50 years.Out of 130 patients 43.8% patients were suffered from Fatty Liver disease while 23.1% were suffered from Alcoholic Hepatitis and 33.1% were suffered from Cirrhosis of Liver. The secondary developments to ALD were portal hypertension (13.8%) followed by Ascities (10.8%) and Hepatitis (10%). The major risk factors involved in ALD was alcohol per se (52.3%) and, alcohol and smoking exaggerate the disease condition. The Periodic (61.5%) and regular basis (38.5%) of alcoholism for chronic period of time may land up with ALD. Polypharmacy is essential for the treatment of ALD as it inoved multiple secondary development to ALD. The patients were intervened and counselled on their individual basis for ALD consequences, and motivated for cessation of alcohol and smoking.
Conclusion: The study enlightens that the early diagnosis and its beneficial outcomes that can exponentially curtail the mortality rate of ALD. Similarly the optimal drug therapy regimen and patient counseling may improve the patient’s quality of life.
Keywords: Alcoholic Liver Disease; Optimal Drug Therapy; Patient Counselling; Improved Quality of Life
TITRIMETRIC ASSAY OF SOME ANTIHISTAMINE DRUGS WITH PYRIDINIUM FLUORO CHROMATE (PFC) REAGENT
Authors: Pandey Ajay Kumar , Dwivedi Dharmendra 
Published: September 2018

In the present paper, simple, convenient accurate, precise and cost effective titrimetric (Visual volumetric) method has been reported for the estimation of some antihistamine drugs e.g. Cyproheptadine hydrochloride (CPH), Fexofenadine hydrochloride (FFH), Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and in their pharmaceutical preparations such as Ciplactin (Tab), Allegra (Tab), Phenergan (Tab and Inj) and Avil (Tab and Inj) with Pyridinium fluoro chromate (PFC) reagent. The principle of this method is based on the fact, that each pharmaceutical drug consists of certain organic functional group which on oxidation by a known excess of potassium iodate in sulphuric acid medium followed by iodometric titration in presence of reagent Pyridinium fluoro chromate (PFC) establishes stoichiometric relationship between drug molecule and an oxidising reagent Pyridinium fluoro chromate (PFC).Different results obtained for each drug during experiment, has been validated by different statistical parameters such as percentage error, standard deviation (SD) and coefficient of variation (CV).Results obtained from these statistical parameters proves the accuracy and precision of adopted method.
AN OVERVIEW ON PHARMACOVIGILANCE: A KEY FOR DRUG SAFETY AND MONITORING
Authors: Kesharwani Vipin , Farooqui Mohd. Asad , Kushwaha Nikhil , Singh Ravi Kesh , Jaiswal Pankaj Kumar 
Published: September 2018

Pharmacovigilance outlined by the globe Health Organization (WHO) because the science and series of activities about the detection, evaluation, understanding rejection of adverse impact or Associate in Nursing different drug connected problem’ and a clinical test could be an analysis study in human volunteers to answer specific health queries. Fastidiously conducted clinical trials square measure quickest and safest thanks to realizing treatment that employment in individuals and thanks to improving health. Play a crucial role in guaranteeing that patient to be provided the safe drug. The Pharmacovigilance has been recognizing to play a crucial role in the rational use of the drug by providing data concerning the adverse impact possess by drug normally population. The information of drug Adverse Drug Reaction (ADRs) are often increased by numerous suggests that such information studies, intensive observation, spontaneous reportage and different new method at dictatorial and scientific level square measure being developed with the intention of step-up Pharmacovigilance. As a result of assessment strategies are not entirely void of individual judgments, integrator reliableness is often low. In conclusions, there's still no methodology universally accepted for casualty assessment of ADRs.
Keywords: Adverse Drug Reaction, Clinical test, Pharmacovigilance, Treatment.
Kombinasi Salam, Pegagan, Alang-Alang, dan Pala Terhadap Fungsi Kardiovaskuler Pasien Hipertensi Esensial
Authors: Nisa Ulfatun , Dewi Tyas Friska 
Published: September 2018

AbstractHypertension is one of cardiovascular risk factors. This study aims to determine the effect of combinationsof bay leaf (Syzygium polyanthum), gotu kola (Centella asiatica), cogon grass (Imperata cylindrica), andnutmeg (Myristica fragrans) to the cardiovascular function of essential hypertensive patient as alternativetherapy. The study used a pre experimental quasi and post test design. Sixty new patients which camebetween Juni-October 2016 that fulfilled inclusion criteria, 18-60 years old with mild hypertension andstable health conditions, and exclusion criteria, doesn’t have severe comorbid disease, pregnant, orhave allergic reaction toward given combination of bay, gotu kola, cogon grass, and nutmeg (jamu).The subjects drank given jamu formula twice a day for 56 days. Measurement of blood pressure, heartrate, RPP, PP, and MAP done once a week in Rumah Riset Jamu Tawangmangu. The results showed adecrease in systolic pressure from 147.16 ± 6.46 mmHg to 132.25 ± 11, 21 mmHg with p value = 0.001%,diastolic pressure decreased from 92.16 ± 2.49 mmHg to 77.83 ± 8 , 98 mmHg with p value = 0.001%,mean arterial pressure, heart rate, RPP, and PP also decreased. The results showed that combination ofbay leaf, gotu kola, cogon grass, nutmeg can increase cardiovascular function by decreasing in bloodpressure, heart rate, RPP, PP, and MAP.Keywords : hypertension, bay leaf, gotu kola, cogon grass, nutmeg
AbstrakHipertensi merupakan faktor resiko terjadinya penyakit kardiovaskular. Penelitian ini bertujuan untukmengetahui efek ramuan kombinasi daun salam (Syzygium polyanthum), pegagan (Centella asiatica),akar alang-alang (Imperata cylindrica), dan biji pala (Myristica fragrans) terhadap fungsi kardiovaskulerpasien hipertensi esensial sebagai terapi alternatif. Desain penelitian yang digunakan pada penelitian iniadalah quasi eksperimental pre dan post test design. Pasien baru berjumlah 60 orang yang datang padabulan Juni-Oktober 2016, yang memenuhi kriteria inklusi usia 18-60 tahun dengan hipertensi ringan sertakondisi pasien stabil dan kriteria eksklusi tidak mempunyai penyakit komorbid yang berat, hamil atauadanya alergi terhadap salah satu tanaman dalam kombinasi tersebut Subyek diberi ramuan jamu yangdiminum 2 kali setiap hari selama 56 hari. Pengukuran terhadap tekanan darah, heart rate, RPP, PP, danMAP dilakukan setiap minggu di Rumah Riset Jamu Tawangmangu. Hasil yang didapat menunjukkanpenurunan tekanan sistolik dari 147,16 ± 6,46 mmHg menjadi 132,25 ± 11, 21 mmHg dengan nilai p= 0,001%, tekanan diastolik menurun dari 92,16 ± 2,49 mmHg menjadi 77,83 ± 8,98 mmHg dengannilai p = 0,001%, tekanan arteri rata-rata, heart rate, RPP, dan PP juga mengalami penurunan. Hal inimenunjukkan kombinasi daun salam, pegagan, akar alang-alang, dan biji pala dapat meningkatkan fungsikardiovaskular dengan menurunkan tekanan sistolik, diastolik, tekanan arteri rata-rata, nilai PP dan RPP.Kata kunci:hipertensi, salam, pegagan, alang-alang, pala
The Effect of Diversity and the Mediating Role of Elaboration on Multidisciplinary Greenhouse Gas Assurance Team Effectiveness
Authors: Ekasingh Erboon , Simnett Roger , Green Wendy J. 
Published: September 2018

ABSTRACT
Greenhouse gas (GHG) assurance is increasingly used by companies as a means to increase stakeholder confidence in the quality of externally reported carbon emissions. The multidisciplinary nature of these engagements means that assurance is performed primarily by multidisciplinary teams. Prior research suggests the effectiveness of such teams could be affected by team composition and team processes. We employ a retrospective field study to examine the impact of educational diversity and team member elaboration on multidisciplinary GHG assurance team effectiveness. Results show that team processes such as sufficiency of elaboration on different team member perspectives significantly increases the perceived effectiveness of the teams. While educational diversity is not found to directly improve perceived team effectiveness, it is found to have a positive effect through increasing perceived sufficiency of elaboration. These findings have important implications for standard setters and audit firms undertaking GHG assurance engagements.
The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up
Authors: Pongrac Barlovic Drazenka , Harjutsalo Valma , Gordin Daniel , Kallio Milla , Forsblom Carol , King George , Groop Per-Henrik 
Published: September 2018

OBJECTIVE
It is well established that diabetic nephropathy increases the risk of cardiovascular disease (CVD), but how severe diabetic retinopathy (SDR) impacts this risk has yet to be determined.

RESEARCH DESIGN AND METHODS
The cumulative incidence of various CVD events, including coronary heart disease (CHD), peripheral artery disease (PAD), and stroke, retrieved from registries, was evaluated in 1,683 individuals with at least a 30-year duration of type 1 diabetes drawn from the Finnish Diabetic Nephropathy Study (FinnDiane). The individuals were divided into four groups according to the presence of diabetic kidney disease (DKD) and/or SDR (+DKD/+SDR, +DKD/−SDR, −DKD/+SDR, and −DKD/−SDR) at baseline visit. Furthermore, age-specific incidences were compared with 4,016 control subjects without diabetes. SDR was defined as laser photocoagulation and DKD as estimated glomerular filtration rate &lt;60 mL/min/1.73 m2.

RESULTS
During 12,872 person-years of follow-up, 416 incident CVD events occurred. Even in the absence of DKD, SDR increased the risk of any CVD (hazard ratio 1.46 [95% CI 1.11–1.92]; P &lt; 0.01), after adjustment for diabetes duration, age at diabetes onset, sex, smoking, blood pressure, waist-to-hip ratio, history of hypoglycemia, and serum lipids. In particular, SDR alone was associated with the risk of PAD (1.90 [1.13–3.17]; P &lt; 0.05) and CHD (1.50 [1.09–2.07; P &lt; 0.05) but not with any stroke. Moreover, DKD increased the CVD risk further (2.85 [2.13–3.81]; P &lt; 0.001). However, the risk was above that of the control subjects without diabetes also in patients without microvascular complications, until the patients reached their seventies.

CONCLUSIONS
SDR alone, even without DKD, increases cardiovascular risk, particularly for PAD, independently of common cardiovascular risk factors in long-standing type 1 diabetes. More remains to be done to fully understand the link between SDR and CVD. This knowledge could help combat the enhanced cardiovascular risk beyond currently available regimens.
Mat nýliða á gagnsemi leiðsagnar í starfi kennara
Authors: Steingrímsdóttir María , Engilbertsson Guðmundur 
Published: September 2018

Í greininni er fjallað um íslenskan hluta norrænnar rannsóknar á nýliðum í grunn- og framhaldsskólum – Nordment1 . Rannsóknin var unnin í samstarfi fræðimanna frá háskólunum í Osló, Gautaborg, Árósum, Turku og Akureyri. Markmið rannsóknarinnar var að kanna hvernig stuðningur í skólum, skólastjórnun og skipulag innan skóla hefur áhrif á það hvernig nýir kennarar aðlagast kennarastarfinu og hvernig þeir meta eigin færni og þær aðstæður sem skólarnir bjóða þeim. Þýði rannsóknarinnar var kennarar á 1.–3. starfsári eða sem höfðu nýlokið þremur starfsárum. Rannsóknin var megindleg og var sami spurningalisti notaður, þýddur og staðfærður, í öllum þátttökulöndunum. Hér á landi var spurningalistinn sendur til 280 kennara, um þriðjungur starfaði í framhaldsskóla og tveir þriðju í grunnskóla. Niðurstöður eru byggðar á svörum 239 kennara, svarhlutfall var rúm 85%.Meginmarkmið þessarar greinar er að gefa innsýn í þann hluta niðurstaðnanna sem lýtur að leiðsögn nýliða í grunn- og framhaldsskólum á Íslandi. Skoðað er hvernig henni er háttað á fyrsta starfsári og hvort tengsl eru milli formlegrar leiðsagnar, tíðni funda með leiðsagnarkennara og mats nýliða á gagnsemi leiðsagnarinnar.Helstu niðurstöður eru þær að leiðsögn hefur áhrif á starfshætti og líðan nýliða ef hún er veitt af kennara sem hefur svipaðan faglegan grunn og nýliðinn og ef þeir funda reglulega saman á leiðsagnartíma. Um þriðjungur þátttakenda hafði hugleitt að hætta í starfi en aðeins tíundi hluti þeirra hafði þó leitað sér að öðru starfi. Ekki voru tengsl milli hugleiðinga þeirra um brotthvarf og þess stuðnings sem þeir fengu í starfi.
Influence of neck position on commonly performed radiographic measurements of the cervical vertebral region in horses
Authors: Beccati Francesca , Santinelli Isabella , Nannarone Sara , Pepe Marco 
Published: September 2018

Abstract
OBJECTIVE To determine the influence of various neck positions on cervical vertebral radiographic measurements in horses.
ANIMALS 18 client-owned horses examined for lameness but free of cervical disease.
PROCEDURES Laterolateral radiographs of the cervical vertebrae from C1 through T1 were acquired for each horse in 3 neck positions (low, neutral, and high). Minimum sagittal diameter, intravertebral sagittal diameter (intra-VSD) ratio, inter-VSD ratio, length of the articular processes joint ratio, vertebral alignment angle, and vertebral fossa angle were measured at each segment in each neck position. Values for the high and low positions were compared with those for the neutral position.
RESULTS No significant differences from neutral position values were identified for minimum sagittal diameter, intra-VSD ratio, and vertebral fossa angle as measured in low and high neck positions. Compared with results in the neutral position, the high position resulted in a greater vertebral alignment angle at C3–4 and inter-VSD ratio at C4–5 and a lower length of the articular processes joint ratio at C2–3, C3–4, and C4–5; the low position resulted in a lower vertebral alignment angle at C4–5. However, all observed differences were small.
CONCLUSIONS AND CLINICAL RELEVANCE Neck position influenced some radiographic measurements of the cervical vertebrae in horses free of cervical disease. However, because several of these measurements were not or were only minimally affected by neck position, some latitude in neck position may be possible without concern about substantially affecting radiographic measurements in this region.