bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periventricular Venous Infarction in an Extremely Premature Infant as the Cause of Schizencephaly
Authors: Ilves Norman , Ilves Pilvi , Õunap Katrin , Laugesaar Rael , Loorits Dagmar , Lintrop Mare , Männamaa Mairi , Metsvaht Tuuli 
Published: September 2019

AbstractSchizencephaly is a disorder of neuronal migration which has been hypothesized to arise from vascular ischemic lesion during the early phase of neuroembryogenesis. We describe a case of a premature boy born at 23 weeks of gestation with neonatal stroke. On the first day of life cranial ultrasonography detected a grade II intraventricular hemorrhage and on day 12 periventricular venous infarction. At the postconceptional age of 40 weeks, magnetic resonance imaging revealed a gray matter–lined cleft, suggesting schizencephaly. We have evidence of the pathogenesis of schizencephaly following vascular ischemic stroke early in neurodevelopment before neuronal migration is completed.
Some trigonometric polynomials with extremely small uniform norm and their applications
Authors: Radomskii A. O. 
Published: September 2019

Abstract
We construct orthogonal trigonometric polynomials satisfying a new spectral condition and such that their

-norms are bounded below and the uniform norm of their partial sums has extremely small order of growth. We obtain new results that relate the uniform norm and

-norm on subspaces of the vector space of trigonometric polynomials.
On orthogonal projections of Nöbeling spaces
Authors: Ageev S. M. 
Published: September 2019

Abstract
Suppose that

. We prove that there is a dense open subset of the Grassmann space

such that the orthogonal projection of the standard Nöbeling space

(which lies in

for sufficiently large

) to every

-dimensional plane in this subset is

-soft and possesses the strong

-universal property with respect to Polish spaces. Every such orthogonal projection is a natural counterpart of the standard Nöbeling space for the category of maps.
New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β
Authors: Irie Kazuhiro 
Published: September 2019

Abstract
Recent investigations suggest that soluble oligomeric amyloid β (Aβ) species may be involved in early onset of Alzheimer’s disease (AD). Using systematic proline replacement, solid-state NMR, and ESR, we identified a toxic turn at position 22 and 23 of Aβ42, the most potent neurotoxic Aβ species. Through radicalization, the toxic turn can induce formation of the C-terminal hydrophobic core to obtain putative Aβ42 dimers and trimers. Synthesized dimer and trimer models showed that the C-terminal hydrophobic core plays a critical role in the formation of high molecular weight oligomers with neurotoxicity. Accordingly, an anti-toxic turn antibody (24B3) that selectively recognizes a toxic dimer model of E22P-Aβ42 was developed. Sandwich enzyme-linked immunosorbent assay with 24B3 and 82E1 detected a significantly higher ratio of Aβ42 with a toxic turn to total Aβ42 in cerebrospinal fluid of AD patients compared with controls, suggesting that 24B3 could be useful for early onset of AD diagnosis.
Endosomal signalling via exosome surface TGFβ‐1
Authors: Shelke Ganesh Vilas , Yin Yanan , Jang Su Chul , Lässer Cecilia , Wennmalm Stefan , Hoffmann Hans Jürgen , Li Li , Gho Yong Song , Nilsson Jonas Andreas , Lötvall Jan 
Published: September 2019

ABSTRACTExtracellular vesicles such as exosomes convey biological messages between cells, either by surface‐to‐surface interaction or by shuttling of bioactive molecules to a recipient cell's cytoplasm. Here we show that exosomes released by mast cells harbour both active and latent transforming growth factor β‐1 (TGFβ‐1) on their surfaces. The latent form of TGFβ‐1 is associated with the exosomes via heparinase‐II and pH‐sensitive elements. These vesicles traffic to the endocytic compartment of recipient human mesenchymal stem cells (MSCs) within 60 min of exposure. Further, the exosomes‐associated TGFβ‐1 is retained within the endosomal compartments at the time of signalling, which results in prolonged cellular signalling compared to free‐TGFβ‐1. These exosomes induce a migratory phenotype in primary MSCs involving SMAD‐dependent pathways. Our results show that mast cell‐derived exosomes are decorated with latent TGFβ‐1 and are retained in recipient MSC endosomes, influencing recipient cell migratory phenotype. We conclude that exosomes can convey signalling within endosomes by delivering bioactive surface ligands to this intracellular compartment.
Design of an Acoustic Levitator for Three-Dimensional Manipulation of Numerous Particles*
Authors: Wu Di , Yin De-Yao , Xiao Zhi-Yuan , Shi Qing-Fan 
Published: September 2019

Abstract

We present a design of an acoustic levitator consisting of three pairs of opposite transducer arrays. Three orthogonal standing waves create a large number of acoustic traps at which the particles are levitated in mid-air. By changing the phase difference of transducer arrays, three-dimensional manipulation of particles is successfully realized. Moreover, the relationship between the translation of particles and the phase difference is experimentally investigated, and the result is in agreement with the theoretical calculation. This design can expand the application of acoustic levitation in many fields, such as biomedicine, ultrasonic motor and new materials processing.
Improving directional radiation quality based on a gradient amplitude acoustic leaky wave antenna
Authors: Lan Jun , Peng Xiuyuan , Zhang Xiaowei , Liu Xiaozhou , Li Yifeng 
Published: September 2019

Abstract
In this work, we show how to modify radiation amplitude with a leaky wave antenna to improve the quality of sound radiation. The designed gradient amplitude leaky wave antenna consists of a straight pipe with periodically loaded membranes, open channels and Helmholtz resonators. An equivalent acoustic composite right/left-hand transmission line that considers the effects of viscous-thermal and viscous-elastic losses is utilized to steer the radiation angle continually from backward to forward as a function of the incident frequency. The numerical results show that by appropriately selecting the structural parameters of the channel and Helmholtz resonator cavity, the quality of the directional radiation is improved based on the gradient distribution of the radiation amplitude and the near unitary phase. Compared with traditional antennas, the proposed gradient amplitude antenna incorporates a frequency scanning capability with gradient amplitude, which improves the directivity quality of the acoustic waves among the operated frequency band, and provides a new design method for acoustic leaky wave antennas.
The E4 brickhouse of Romania – a local proved nZEB
Authors: Mladin E C 
Published: September 2019

Abstract
The nZEB concept, intensively required by the European directives, is intended to include buildings with very low energy consumptions from fossil fuels and it will be mandatory for all new buildings starting with 2021. This paper explores the design stages of a process that meets the requirements of the “E4 program” initiated in Europe by the Wienerberger company for buildings intensively using ceramic elements. The 4 Es stand for Energy, Economy, Ecology and Emotion. Therefore, the paper presents a house in terms of architecture and installations for a healthy, energy efficient, environmentally friendly and affordable home, where ceramic building elements simultaneously stand for increased thermal and mechanical resistance and thermal mass. Energy performance assessment is accompanied by economic analysis and primary energy calculations. Once the building has been completed and occupied by the owner family of 2 adults and two children, the energy use and indoor comfort were monitored for two years. The real energy performance could thus be assessed and compared to the design stage estimate. Results indicated an over-compliance with the nZEB criteria set for Romania. The study reflects the value of simulations at the building design stage and the differences that occur between statistical approach and real building performance.
Research on the fire endurance of the silica sand membrane
Authors: Kaya A , Çelen S , Akyol U 
Published: September 2019

Abstract
In this study, the fire endurance, density, low-temperature deflection, penetration and ring-ball method tests of the membrane produced throughout the mixing of Bitumen, IPP (isotactic polypropylene), LDPE (Low-density polyethylene) calcite and silica sand at varying proportions were performed and the test results were compared with the membrane used today. In our study, TS 120 EN 1427, TS 118 EN 1426, TS EN 13501-1, KG-TL-029 testing methods were used. The density of the silica material we have obtained was measured at 1.3782 g/cm3, the endurance of the material was found out to be better, softening temperature was measured at 155°C, brittleness temperature at -7°C and the fire class was found out to be as E.
Prediction of spark ignition engine fuel consumption for different functional conditions using a theoretical model
Authors: Vornicu V , Ulian T , Rakosi E , Manolache G , Talif S 
Published: September 2019

Abstract
The theoretical model estimates the characteristic parameters of a car spark ignition engine by using complex functions. Analyzing the variation of the efficiencies and the fuel consumption at various operating regimes it is possible to optimize them according to the operating regime of the car. It is also studied a method for estimation of the specific fuel consumption of the spark ignition engine by considering engine operation in variable mode. The theoretical study presented by authors contributes actively to the optimization of the interaction between vehicle and propulsion system by identifying low fuel consumption modes.
Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis
Authors: Fama Angelo , Larson Melissa C , Link Brian K , Habermann Thomas M , Feldman Andrew L , Call Timothy G , Ansell Stephen M , Liebow Mark , Xiang Jinhua , Maurer Matthew J , Slager Susan L , Nowakowski Grzegorz S , Stapleton Jack T , Cerhan James R 
Published: September 2019

AbstractBackgroundHuman pegivirus (HPgV) is a single-strand RNA virus belonging to the Flaviviridae. Although no definitive association between HPgV infection and disease has been identified, previous studies have suggested an association of HPgV viremia with risk of lymphomas.MethodsWe conducted a systematic review and meta-analysis, including 1 cohort study and 14 case-control studies, assessing the association of HPgV viremia with adult lymphomas. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model, overall and by geographic region and lymphoma subtype.ResultsThe overall OR for lymphoma was 2.85 (95% CI, 1.98–4.11), with statistically significantly elevated ORs observed in 8 of 15 studies. There was a small amount of heterogeneity among studies (I2 = 28.9%; Q = 18.27, P = .16), and the funnel plot provided no evidence for publication bias. The strongest association with lymphoma risk was observed for studies from Southern Europe (OR, 5.68 [95% CI, 1.98–16.3]), whereas weaker ORs (with 95% CIs) were observed for studies from North America (2.24 [1.76–2.85]), Northern Europe (2.90 [.45–18.7), and the Middle East (2.51 [.87–7.27]), but all of similar magnitude. Participants with HPgV viremia had statistically significantly increased risks (OR [95% CI]) for developing diffuse large B-cell (3.29 [1.63–6.62]), follicular (3.01 [1.95–4.63]), marginal zone (1.90 [1.13–3.18]), and T-cell (2.11 [1.17–3.89]) lymphomas, while the risk for Hodgkin lymphoma (3.53 [.48–25.9]) and chronic lymphocytic leukemia (1.45 [.45–4.66]) were increased but did not achieve statistical significance.ConclusionsThis meta-analysis supports a positive association of HPgV viremia with lymphoma risk, overall and for the major lymphoma subtypes.
A first case report of dapsone inducing recurrent ventricular arrhythmia
Authors: Wong Bethany , Saiva Lavanya , Buckley John , Galvin Joseph 
Published: September 2019

Abstract

Background
Ventricular arrhythmias (VAs) are life-threatening arrhythmias which are associated with significant morbidity and mortality. Ventricular arrhythmias are induced by a change in the myocardial environment altering cardiomyocyte electrophysiology. The substrate for VA includes myocardial scar, electrolyte disturbances, and drugs altering cellular electrophysiology.

Case summary
Here, we present a case of a 52-year-old man with known ischaemic cardiomyopathy, presenting with VA storms secondary to dapsone, an anti-microbial used in this case for the prophylaxis of pneumocystis pneumonia. This is the first case linking dapsone to the development of VAs. Ventricular arrhythmias storm occurred towards the end of the course of anti-microbial therapy and the patient was referred for sympathectomy. However, following the end of treatment, no further VA occurred and sympathectomy was therefore avoided.

Discussion
The underlying mechanism for the association between dapsone treatment and VA is unclear and a prolonged QTc was not observed in our case. It is important to recognize that every drug has many physiological effects and in patients with underlying diseases whereby there is already an unfavourable environment, additional drugs can lower the threshold of triggering an arrhythmia and the result can be life-threatening. In a patient with ischaemic cardiomyopathy, where underlying substrate for VA may already exist, the introduction of dapsone could lower the threshold for development of arrhythmia.
Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir? A Nested Case-Control Study Within the French Hospital Database on HIV
Authors: Costagliola Dominique , Potard Valérie , Lang Sylvie , de Castro Nathalie , Cotte Laurent , Duval Xavier , Duvivier Claudine , Grabar Sophie , Mary-Krause Murielle , Partisani Marialuisa , Ronot-Bregigeon Sylvie , Simon Anne , Tattevin Pierre , Weiss Laurence , Zucman David , Katlama Christine , Raffi François , Boccara Franck 
Published: September 2019

Abstract

Background
The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) study has reported an increased risk of cardiovascular diseases in people with human immunodeficiency virus who were exposed to darunavir (DRV) but not to atazanavir (ATV). Our objective was to evaluate associations between ATV or DRV exposures and the risk of myocardial infarction (MI) in a nested case-control study within ANRS-CO4 French Hospital Database on HIV (FHDH).

Methods
Cases were individuals who had a first validated MI between 2006 and 2012. Up to 5 controls were selected at random with replacement among individuals with no history of MI, followed at the time of MI diagnosis, and matched for age and sex. Conditional logistic regression models were used to adjust for potential confounders (MI risk factors and HIV-related parameters) and for cumulative exposure to each antiretroviral drug (ARV).

Results
Overall, 408 MI cases and 1250 controls were included: 109 (27%) cases and 288 (23%) controls had been exposed to ATV, and 41 (10%) cases and 107 (9%) controls had been exposed to DRV. There was no significant association between exposure to ATV (adjusted odds ratio [OR] = 1.54; 95% confidence interval [CI], .87–2.73) or DRV (adjusted OR = 0.51; 95% CI, .11–2.32) and the risk of MI.

Conclusions
In FHDH, exposures to ATV or to DRV were not significantly associated with the risk of MI, adjusting for complete ARV history, contrary to the analysis in DAD.
Asteroseismic investigation of 20 planet and planet-candidate host stars
Authors: Kayhan C , Yıldız M , Çelik Orhan Z 
Published: September 2019

ABSTRACT
Planets and planet candidates are subjected to great investigation in recent years. In this study, we analyse 20 planet and planet-candidate host stars at different evolutionary phases. We construct stellar interior models of the host stars with the mesa e.volution code and obtain their fundamental parameters under influence of observational asteroseismic and non-asteroseismic constraints. Model mass range of the host stars is 0.74–1.55 $\rm M_{\odot }$. The mean value of the so-called large separation between oscillation frequencies and its variation about the minima shows the diagnostic potential of asteroseismic properties. Comparison of variations of model and observed large separations versus the oscillation frequencies leads to inference of fundamental parameters of the host stars. Using these parameters, we revise orbital and fundamental parameters of 34 planets and four planet candidates. According to our findings, radius range of the planets is 0.35–16.50 $\rm R_{{\oplus }}$. The maximum difference between the transit and revised radii occurs for Kepler-444b-f is about 25 per cent.
Calibration of the mixing-length theory for structures of helium-dominated atmosphere white dwarfs
Authors: Cukanovaite E , Tremblay P-E , Freytag B , Ludwig H-G , Fontaine G , Brassard P , Toloza O , Koester D 
Published: September 2019

ABSTRACT
We perform a calibration of the mixing-length parameter at the bottom boundary of the convection zone for helium-dominated atmospheres of white dwarfs. This calibration is based on a grid of 3D DB (pure-helium) and DBA (helium-dominated with traces of hydrogen) model atmospheres computed with the co5bold radiation-hydrodynamics code, and a grid of 1D DB and DBA envelope structures. The 3D models span a parameter space of hydrogen-to-helium abundances in the range −10.0 ≤ log (H/He) ≤−2.0, surface gravities in the range 7.5 ≤ log g ≤ 9.0, and effective temperatures in the range 12 000 K ≲ Teff ≲ 34 000 K. The 1D envelopes cover a similar atmospheric parameter range, but are also calculated with different values of the mixing-length parameter, namely 0.4 ≤ ML2/α ≤ 1.4. The calibration is performed based on two definitions of the bottom boundary of the convection zone: the Schwarzschild and the zero convective flux boundaries. Thus, our calibration is relevant for applications involving the bulk properties of the convection zone including its total mass, which excludes the spectroscopic technique. Overall, the calibrated ML2/α is smaller than what is commonly used in evolutionary models and theoretical determinations of the blue edge of the instability strip for pulsating DB and DBA stars. With calibrated ML2/α we are able to deduce more accurate convection zone sizes needed for studies of planetary debris mixing and dredge-up of carbon from the core. We highlight this by calculating examples of metal-rich 3D DBAZ models and finding their convection zone masses. Mixing-length calibration represents the first step of in-depth investigations of convective overshoot in white dwarfs with helium-dominated atmospheres.
Dissociative electron recombination of NH2CHOH+ and implications for interstellar formamide abundance
Authors: Ayouz M A , Yuen C H , Balucani N , Ceccarelli C , Schneider I F , Kokoouline V 
Published: September 2019

ABSTRACTFormamide is a potentially important molecule in the context of pre-biotic chemistry, since reactions involving it can lead to precursors of genetic and metabolic molecules. Being abundant in cometary material and in star-forming regions, the formation and destruction routes of interstellar formamide have been the focus of several studies. In this work, we focus on the electron recombination of protonated formamide, an important step of its destruction routes, by performing rigorous ab initio calculations of this process. We found that our values are in good agreement with previous qualitative estimates of the global rate coefficients. On the contrary, we propose a substantial revision of the products and branching ratios. Finally, we justify and emphasize the importance of carrying out similar theoretical calculations on the largest possible number of complex species of astrochemical interest.
Whole-Field Indocyanine Green Intensity Analysis to Intraoperatively Predict Cerebral Hyperperfusion Syndrome Following Superficial Temporal Artery-Middle Cerebral Artery Bypass: A Retrospective Case-Control Study in 7-Year Experience With 112 Cases
Authors: Sato Yosuke , Sugiyama Tatsuya , Mizutani Tohru 
Published: September 2019

Abstract

BACKGROUND
Intraoperative prediction of postoperative cerebral hyperperfusion syndrome (CHS) after cerebrovascular bypass surgery is challenging.

OBJECTIVE
To conduct a retrospective case-control study with indocyanine green (ICG) intensity analysis of the superficial temporal artery-middle cerebral artery (STA-MCA) bypass and investigate whether its washout pattern might be a marker for intraoperative prediction of CHS.

METHODS
Between 2012 and 2018, 6 of 112 patients (5.4%) that underwent STA-MCA bypass exhibited CHS. We selected 5 patients with CHS (3 with atherosclerotic cerebrovascular disease [ASCVD] and 2 with moyamoya) and 15 patients without CHS (60% ASCVD and 40% moyamoya) as a matched control group. During prebypass and postbypass, washout times (WTs) for the first 10%, 25%, 50%, and 75% of maximum ICG intensity measured in the whole-camera field were compared between groups. The changes in WT (ΔWT) from prebypass to postbypass for each ICG intensity level were compared between groups. The cutoff ΔWTs, sensitivities, and specificities were also calculated.

RESULTS
Postbypass WTs were significantly longer in the CHS group than the control group at all ICG intensities (P < .05). ΔWT was significantly greater in the CHS group than the control group for the first 10%, 25%, and 50% ICG intensities (P < .001). A cutoff ΔWT of ≥2.66 s for the first 50% ICG intensity showed a sensitivity of 100% and specificity of 100%.

CONCLUSION
We found that a ΔWT ≥2.66 s for the first 50% ICG intensity could be an intraoperative predictive factor for CHS.
PARAINEN PEARL SHIPPING LTD v KRISTIAN GERHARD JEBSEN SKIPSREDERI AS
Authors:   PATENTS COURT
Published: September 2019

Abstract
H1 Patents – European patents – Declaration of non-infringement – Ships – System “for” unloading powdery cargo – Cement handling – Patentee’s ship equipped with patented system declared total loss – Ship re-floated – Title to ship passing to third party – Patented system not operational – Restrictions as to future use – Ship re-sold – Patentee not exercising option to purchase – Later purchasers putting system back into operation – Whether work done amounting to making repair or replacement – Exhaustion of rights – Implied licence – Estoppel
A Case of Papulonodular Mucinosis in a Patient With Systemic Lupus Erythematosus
Authors: Dallo Christopher , Lee Keagan , Cragun W. Chad , Lee Mui 
Published: September 2019

Abstract:Papulonodular mucinosis is a distinctive lupus erythematosus cutaneous variant that generally occurs in patients with systemic lupus erythematosus. Despite a higher incidence of SLE in women, lupus cutaneous mucinosis occurs more frequently in men. Typically, papulonodular mucinosis appears as asymptomatic, flesh-colored papules and nodules with a propensity for the trunk and upper extremities. Herein, we report a case of papulonodular mucinosis associated with systemic lupus erythematosus in a middle-aged woman. On presentation, patient had multiple flesh-colored papules coalescing into plaques on the trunk and upper extremities. Histological findings of the lesions demonstrated a pale dermis secondary to profuse mucin deposition. Immunofluorescent staining revealed a "lupus band" with granular deposition of immunoglobulins/complement proteins at the dermal–epidermal junction.