bluuebunny/crossref_metadata_2025_split huggingface dataset:
The emerging role of alternatively activated macrophages to treat acute liver injury
Authors: Humphries Chris , Addison Melisande L. , Dear James W. , Forbes Stuart J. 
Published: November 2024

Abstract
Acute liver injury (ALI) has a clear requirement for novel therapies. One emerging option is the use of alternatively activated macrophages (AAMs); a distinct subtype of macrophage with a role in liver injury control and repair. In this comprehensive review, we provide an overview of the current limited options for ALI, and the potential advantages offered by AAMs. We describe the evidence supporting their use from in vitro studies, pre-clinical animal studies, and human clinical trials. We suggest why the first evidence for the clinical use of AAMs is likely to be found in acetaminophen toxicity, and discuss the specific evidence for AAM use in this population, as well as potential applications for AAMs in other patient populations. The key domains by which the performance of AAMs for the treatment of ALI will be assessed are identified, and remaining challenges to the successful delivery of AAMs to clinic are explored.
Tetracycline and Oxacillin Act Synergistically on Biofilms and Display Increased Efficacy In Vivo Against Staphylococcus aureus
Authors: Tooke Amy K. , Hodges Rebecca E. , Pyrah Josie F. , Bayles Kenneth W. , Renshaw Stephen A. , Foster Simon J. 
Published: November 2024

AbstractOxacillin (bactericidal) and tetracycline (bacteriostatic) are clinically relevant antibiotics that are routinely prescribed to treat Staphylococcus aureus infections but not conventionally used in combination. There is an urgent need for treatment regimens that can act upon biofilms during infection, associated with chronic infections on indwelling devices, as well as acute planktonic (systemic) infection. Here we show that in an in vitro model oxacillin and tetracycline act synergistically against S. aureus UAMS-1 biofilms, reducing the concentration of both antibiotics necessary to eradicate an established biofilm. Using an in vivo zebrafish larval infection model with S.aureus NewHG, they display improved bacterial clearance compared to each drug alone and can counteract a loss of host phagocytes, an important innate defence against S. aureus. In these cases, the bacteriostatic nature of tetracycline enhances rather than dampens the bactericidal action of oxacillin, although an exact mechanism remains to be elucidated. We suggest a dual therapy could be of clinical use against biofilm-forming S. aureus and has a potential use in patients with a compromised immune system.
Polygenic risk for psychotic disorders in relation to cardiac autonomic dysfunction in unmedicated patients with schizophrenia
Authors: Refisch Alexander , Papiol Sergi , Schumann Andy , Malchow Berend , Bär Karl-Jürgen 
Published: November 2024

AbstractCardiac autonomic dysfunction (CADF), mainly characterized by increased heart rate, decreased heart rate variability, and loss of vagal modulation, has been extensively described in patients with schizophrenia (SCZ) and their healthy first-degree relatives. As such, it represents an apparent physiological link that contributes to the increased cardiovascular mortality in these patients. Common genetic variation is a putative underlying mechanism, along with lifestyle factors and antipsychotic medications. However, the extent to which CADF is associated with genetic factors for SCZ is unknown. A sample of 83 drug-naive SCZ patients and 96 healthy controls, all of European origin, underwent a 30-minute autonomic assessment under resting conditions. We incorporated parameters from several domains into our model, including time and frequency domains (mean heart rate, low/high frequency ratio) and compression entropy, each of which provides different insights into the dynamics of cardiac autonomic function. These parameters were used as outcome variables in linear regression models with polygenic risk scores (PRS) for SCZ as predictors and age, sex, BMI, smoking status, principal components of ancestry and diagnosis as covariates. Of the three CADF parameters, SCZ PRS was significantly associated with mean heart rate in the combined case/control sample. However, this association was was no longer significant after including diagnosis as a covariate (p = 0.29). In contrast, diagnostic status is statistically significant for all three CADF parameters, accounting for a significantly greater proportion of the variance in mean heart rate compared to SCZ PRS (approximately 16% vs. 4%). Despite evidence for a common genetic basis of CADF and SCZ, we were unable to provide further support for an association between the polygenic burden of SCZ and cardiac autonomic function beyond the diagnostic state. This suggests that there are other important characteristics associated with SCZ that lead to CADF that are not captured by SCZ PRS.
Competition and coordination between traditional and internet hospitals
Authors: Li Zhong-Ping , Chang Aichih Jasmine 
Published: November 2024

AbstractMotivated by the recent emergence and rapid growth of online healthcare platforms, this paper investigates its impacts on the healthcare ecosystem by taking into consideration of heterogeneous patients, homogeneous service providers and profit-driven hospitals. A game-theoretical model with a queueing framework is developed, and two healthcare systems are considered, including a monopolistic system with either an offline, traditional hospital, or an online, Internet hospital, and a duopolistic system with both kinds of hospitals. Our study finds that in both systems a large population of patients always increases the healthcare supply and demand and the hospital utilization, which leads to an improvement not only in the hospital profitability, but also in the welfare of both patients and service providers. When considering a monopolistic system only, our study suggests that the monopolistic Internet hospital outperforms its counterpart in hospital utilization only when the wait cost is not high (i.e., patients are less sensitive to wait time), especially when the wait cost is medium and the patient-provider ratio is small. When considering a duopolistic system, this study concludes that the decisions of patients, service providers, and hospital managers of both hospitals are interrelated, and that a large population of service providers increases its hospital’s supply, demand, and wage rate, while decreases its wait times. When comparing the two monopolistic with the duopolistic system, the latter outperforms and improves every entity’s utility (i.e., patients, hospital, and society) when there is abundance of service providers with more being allocated to the Internet hospital, whereas the monopolistic system dominates when the patient population is large, and more providers are allocated to the traditional hospital.
A hybrid metaheuristic and simulation approach towards green project scheduling
Authors: Rabet Rahmat , Sajadi Seyed Mojtaba , Tootoonchy Mahshid 
Published: November 2024

AbstractThis research tackles the environmental concern of greenhouse gas emissions in the execution of projects, with a focus on multi-site projects where the transportation of resources is a major source of emissions. Despite growing consciousness among consumers and stakeholders about sustainability, the domain of project scheduling has often overlooked the environmental impact. This paper seeks to bridge this oversight by exploring how to reduce greenhouse gas emissions during both project activities and resource transportation. A novel approach is proposed, combining a simulation model with an improved non-dominated sorted genetic algorithm. The simulation model incorporates the stochastic nature of emission rates and costs. This method is further refined with innovative techniques such as magnet-based crossover and mode reassignment. The former is a genetic algorithm operation inspired by magnetic attraction, which allows for a more diverse and effective exploration of solutions by aligning similar ’genes’ from parent solutions. The latter is a strategy for reallocating resources during project execution to optimize efficiency and reduce emissions. The efficacy of the proposed method is validated through testing on 2810 scenarios from established benchmark libraries, 100 additional scenarios adhering to the conventional multi-site problems, and a case study. The Best-Worst Method (BWM) is applied for identifying the best solution. The findings indicate substantial enhancements compared to traditional methods with a 12.7% decrease in project duration, 11.4% in costs, and a remarkable 13.6% reduction in greenhouse gas emissions.
Epistemic commitments have no “Off” button: on the embodiment of commitments by way of model formulation
Authors: Hasnes-Beninson Zvi 
Published: November 2024

AbstractThe current paper examines how a commitment to a principle, adhered to by an individual agent, becomes an accepted standard of an epistemic community. Addressing this question requires three steps: first, to define the terms used throughout the paper, and especially the characteristics of commitments to a principle. The second step is to find a mechanism through which such epistemic commitments are introduced to an epistemic community and in certain cases are adopted as the standard by the community. While there could be several such mechanisms, the current paper focuses on the practice of model formulation. The third step is to demonstrate the analytical framework developed in the first two steps in a case study. The case study chosen for this paper is the unique approach to feedback analysis adopted by the ecologist and population geneticist Richard Levins. In what follows I will show that part of the features that made Levins’ approach unique was his Marxist commitments, and his attempt to embody those commitments in feedback analysis by formally representing them as modeling assumptions.
Association between long-term PM2.5 exposure and mortality on Sumatra Island: Indonesian Family Life Survey (IFLS) 2000–2014
Authors: Siregar Sepridawati , Idiawati Nora , Berekute Abiyu Kerebo , Maulana Muchsin , Pan Wen-Chi , Yu Kuo-Pin 
Published: November 2024

AbstractThe concentration of PM2.5 (particulate matter with a diameter < 2.5 µm) on Sumatra Island has increased, mainly because of forest and peatland fires, transportation, and industry. Biomass burning releases partially burned carbon into the atmosphere, resulting in a smoky haze containing PM2.5. Air quality has deteriorated quickly, and PM2.5 has become a major health hazard in Indonesia. Studies on long-term exposure to PM2.5 have indicated its associations with both morbidity and mortality. Here, we measured long-term (2000–2014) exposure to PM2.5 on the basis of satellite-derived aerosol optical depth measurements (1 × 1 km2) used to predict ground-level PM2.5 concentrations. Additionally, population data on Sumatra Island residents from the fourth wave of the Indonesian Family Life Survey (IFLS) were obtained. We investigated the association between long-term PM2.5 exposure and mortality with a retrospective cohort study design. A total of 2409 subjects aged ≥ 40 years participated in the IFLS-3 beginning in November 2000, and we examined mortality outcomes until the IFLS-5 in September 2014. We used Cox regression models to calculate hazard ratios (HRs) of mortality associated with PM2.5 exposure. According to the adjusted model, the mortality HRs per 10 µg/m3 increase in PM2.5 concentration were 1.10 (95% CI 1.03, 1.17) for all natural causes, 1.17 (95% CI 1.05, 1.25) for cardiovascular causes, and 1.19 (95% CI 1.04, 1.36) for respiratory causes. Long-term exposure to PM2.5 was associated with all-natural, cardiovascular, and respiratory mortality on Sumatra Island, where PM2.5 levels exceed the WHO and US-EPA air quality standards.
Radiological characterization related to lithology and risk assessment of bottled natural mineral water
Authors: Martínez Joana , Peñalver Alejandra , Riu Jordi , Aguilar Carme , Borrull Francesc 
Published: November 2024

AbstractThe enhancement of natural radioactivity in groundwater, specifically in natural mineral water, is related to the lithological formations through which water bodies or courses pass. Although natural mineral waters are exempt from monitoring for radioactive substances according to Council Directive 2013/51/EURATOM, this study focuses on the radiological characterization of natural mineral water under Spanish Royal Decree 3/2023. The water studied was taken from Catalan aquifers with different lithological characteristics (sedimentary, metamorphic or granitic) and is sold on local markets. Moreover, radiological data on the water was correlated with its lithological origin and the health risk for different age groups was assessed. Our results showed that of the 26 natural mineral waters studied, 10 exceeded gross alpha screening value (100 mBq/L), all from granitic aquifers. Further research on natural individual radionuclides was conducted on these ten samples. 234U and 238U were at around 1100–1600 mBq/L. In addition, 210Pb was found in two samples, which also presented the highest 226Ra activity, associated with granitic bedrock and the presence of 210Po. The annual effective dose was 179.0 µSv/year and 145.9 µSv/year, exceeding 100 µSv/year mainly due to the contribution of 210Pb > 234,238U > 210Po > 226Ra, in this order. After assessing the lifetime cancer risk, these two samples were determined not to pose a health risk due to ingestion. Although no radiological monitoring is required for natural mineral water, further surveillance is recommendable.
Scale-specific effects of urban landscape pattern on the COVID-19 epidemic in Hangzhou, China
Authors: Chen Junbin , Sun Zhou , Wu Yu , Hu Guang , Wen Yanping 
Published: November 2024

Abstract
Context
Understanding the scale-specific effects of different landscape variables on the COVID-19 epidemics is critical for developing the precise and effective prevention and control strategies within urban areas.

Objective
Based on the landscape epidemiology framework, we analyzed the scale-specific effects of urban landscape pattern on COVID-19 epidemics in Hangzhou, China.

Methods
We collected COVID-19 cases in Hangzhou from 2020‒2022 and combined the datasets of land use and land cover (LULC) and social gathering point (SGP) to quantify the urban landscape pattern. Optimal general linear model with stepwise regression was applied to explore the dominant landscape factors driving the COVID-19 transmission in the city. Furthermore, multi-scale geographically weighted regression illustrated the spatial heterogeneity and scale specificity of these landscape variables’ effects to COVID-19 epidemic.

Results
Eight landscape variables of LULC and SGP patterns were identified which explained 68.5% of the variance in spatial risk of COVID-19. Different optimal bandwidths across these variables in MGWR indicated their scale-specific effects. LSI of green space enhanced the spatial risk across the entire region. The effects of landscape contagion, the number of water bodies, LSI of cropland and built-up areas, and the density of commercial houses were detected to vary between urban and suburban areas. The effects of LSI of water bodies and the density of shopping malls were found to vary among different districts.

Conclusions
In this study, we firstly discriminated the scale-specific effects of different landscape variables on the COVID-19 epidemic in the urban region. These findings can help to optimize the differentiated zoning prevention and control strategies for COVID-19 in cities and guide policy-making and urban planning at a multi-scale hierarchical perspective to improve public health and urban sustainability.
Fermionic integrable models and graded Borchers triples
Authors: Bostelmann Henning , Cadamuro Daniela 
Published: November 2024

AbstractWe provide an operator-algebraic construction of integrable models of quantum field theory on 1+1-dimensional Minkowski space with fermionic scattering states. These are obtained by a grading of the wedge-local fields or, alternatively, of the underlying Borchers triple defining the theory. This leads to a net of graded-local field algebras, of which the even part can be considered observable, although it is lacking Haag duality. Importantly, the nuclearity condition implying nontriviality of the local field algebras is independent of the grading, so that existing results on this technical question can be utilized. Application of Haag–Ruelle scattering theory confirms that the asymptotic particles are indeed fermionic. We also discuss connections with the form factor programme.
Numerical analyses of acoustic vibrational resonance in a Helmholtz resonator
Authors: Omoteso K. A. , Ozioko O. , Bagdasar O. , Roy-Layinde T. O. , Diala U. H. 
Published: November 2024

AbstractIn this study, the numerical analyses of a system, which describes the motion of air particles in the cavity of a Helmholtz resonator (HR), excited by a sound wave, was conducted. The low-frequency (LF) signal in the acoustic field is amplitude-modulated by an additive high-frequency (HF) perturbation, which can enhance the detection of the low-frequency, through Vibrational Resonance (VR) phenomena. The focus was on the combined effect, of amplitude and frequency of the acoustic excitation, on the motion of particles and induction of resonance. It was demonstrated that the system exhibits several nonlinear behaviours, VR ceasing to exist for a particular motion of the particles, which is dictated by the excitation frequency in relation to the resonator’s geometry. Furthermore, the regimes in which the performance of the system can be optimized, was identified, which facilitated the design of broadband acoustic resonators, suitable for most applications.
Insight into the dynamics of protected and non-protected carbon pools in four soils with different land uses
Authors: Filep Tibor , Zacháry Dóra , Kovács Andrea Balláné , Király Csilla , Béni Áron , Jakab Gergely , Juhász Evelin Kármen , Szalai Zoltán 
Published: November 2024

Abstract
Background and aims
To provide insight into the patterns of soil organic matter decomposition, changes in the quantity of biopolymers and the correlation between them were followed using 2D correlation spectroscopy (2DCOS) FTIR.

Methods
Soil organic matter fractions with different vegetation/land use (grass, spruce, oak and arable) were examined in a 1-year laboratory incubation. The non-protected organic matter fraction was calculated in terms of particulate organic matter (POM), the carbon stabilized in aggregates as S + A (sand + aggregates), and the mineral-associated organic matter (MAOM) as the s + c (silt and clay) fraction.

Results
Forest soils (spruce, oak) exhibited high C and N accumulation in the POM fraction (48, 43% and 29, 22% for spruce and oak, respectively) due to the limited decomposition, caused by low pH and high soil C/N ratio. The 2DCOS analysis revealed that carbohydrate-protein and carbohydrate-lignin correlations could be observed most frequently during incubation. The carbohydrate-protein correlation was negative in all cases, for all fractions and for all vegetation types, which suggests biogeochemical linkage between these biopolymers. The temporal order of the spectral changes was widely varied for the vegetation types and especially for the SOM fractions. Lipid/Lignin → Carbohydrate or Lipid → Lignin/Carboxyl/Protein sequences were found for the protected carbon pools (S + A and s + c), possibly because of the readily available abundant N compounds present in MAOM.

Conclusion
Although lipids and lignin are considered as chemically stable materials that commonly remain constant during decomposition, these compounds were found to be very susceptible in all the fractions.
What Should We Say to Denmark? Mentalism as an Essential Complement to Behavourism
Authors: Kim Hwa Young 
Published: November 2024

AbstractShould answers to fundamental questions of political philosophy be ‘convincing’ and ‘meaningful’ to real people with vested interests? Normative behaviourists argue that they should, and this can be achieved by avoiding the use of intuitions in our normative theorizing and instead relying on long-term empirical evidence of human behaviour. In this paper, I argue that to obtain the full benefits of behaviourism, it needs to be accompanied by some form of mentalism. Normative behaviourism sacrifices critical distance from the status quo to provide answers that are convincing and meaningful. However, there is no clear benefit obtained from this sacrifice. Furthermore, because of behaviourism’s institutional focus in its current form, it does not have much to say about how to achieve its goals. Behaviourists can solve both problems by incorporating a mentalist account of political agency, one that determines what values and ideals political agents should fight for and helps political agents develop strategies to achieve their goals.
Interplay among Language and Home Variables in Lebanese Students’ Science TIMSS Performance: A Linguistic and Economic Capital Perspective
Authors: Salloum Sara , Younes Rayya , Antoun Maya 
Published: November 2024

AbstractIn Lebanon, science is taught in an international language (French or English) based on a language-in-education policy rooted in Lebanon’s colonial history. Given the intersection among social/socioeconomic class, educational equity, and science performance, learning science in a language other than one’s own raises concerns around economically-marginalized students’ opportunities for quality science education and their development of science understandings and discourse. Bourdieu’s lens of cultural and linguistic capital was utilized to better understand the interplay among socioeconomic status and science performance. Specifically, we examined how different home context variables (including language) influence Lebanese learners’ science performance in the Trends in International Mathematics and Science Study (TIMSS) assessment. Using hierarchical linear modeling (HLM), we looked at how students performed in science based on how often they spoke the language of the test at home and other home variables such as parents’ education level. The findings indicate that language and various economic and home variables were significantly associated with science performance. Language had a differing effect for English and French tracks, whereby parents’ education level and other home variables emerged more significantly for French track students. Our study underscores the importance of preparing and supporting science teachers for equitable, asset-oriented, and linguistically responsive teaching that enhances diverse learners’ equitable participation and opportunities in the science classroom.