bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Skin Wrap dalam Mencegah Hipotermia pada Kelahiran Bayi Prematur
Authors: Casman Casman 
Published: January 2019

ABSTRAK

Tujuan: untuk menelaah efektifitas skin wrap dalam mencegah hipotermia pada kelahiran bayi prematur. Metode: Studi literatur dipilih dimana artikel diambil dari 3 database yaitu ScienceDirect, Wiley dan Scopus. Semua artikel dicari dengan menggunakan kata kunci: skin wrap and premature infants. Dua puluh dua artikel berhasil terpilih. Hasil: Hanya 1 artikel yang tidak membuktikan bahwa penggunaan plastik tidak efektif mempertahankan suhu tubuh bayi (p=0.07). Penggunaan plastik rata-rata menggunakan plastik non steril dan plastik yang direkatkan ke tubuh bayi tanpa mengeringkan tubuh bayi. Perlekatan plastik pada bayi bisa seluruh tubuh dan kepala atau hanya sampai leher. Kesimpulan: penggunaan plastik segera setelah lahir dengan vynil isolation bag atau polyethylene plastic dapat mencegah kehilangan panas pada bayi prematur.
STUDI FENOMENOLOGI: KEBUTUHAN DUKUNGAN SOSIAL PADA REMAJA DENGAN DIABETES MELLITUS TIPE-1
Authors: Dewi Winasari 
Published: January 2019

Setiap tahun semakin terjadi peningkatan jumlah anak penderita DM tipe-1. Tanpa dukungan sosial yang mencukupi, DM tipe-1 sering mengganggu kehidupan normal penderitanya. Tujuan penelitian adalah untuk mengeksplorasi kebutuhan dukungan sosial pada remaja dengan DM tipe-1. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi. Jumlah partisipan dalam penelitian ini adalah sebanyak 6 orang remaja dengan DM tipe-1. Teknik pengambilan sampel menggunakan purposive sampling. Analisis data menggunakan analisis tematik. Hasil penelitian mengidentifikasi 4 tema, yaitu ketergantungan pada orang sekitar, hidup dikontrol, kebahagiaan akan dukungan, dan keinginan seperti remaja lainnya. Berdasarkan hasil penelitian, direkomendasikan bagi perawat anak dapat berkoordinasi dengan pihak lain untuk mengembangkan inovasi pelayanan keperawatan dalam memberikan asuhan keperawatan secara holistik dan komprehensif pada remaja dengan DM tipe-1 sehingga kebutuhan dukungan sosialnya dapat terpenuhi.
pengaruh Senam Kaki DM terhadap Perubahan Nadi Dorsalis Pedis Klien Diabetes Mellitus Di Puskesmas Dinoyo Malang
Authors: Arif Taufan 
Published: January 2019

Perubahan gaya hidup terutama dikota besar,menyebabkanpeningkatan prevalensi penyakit degeneratif seperti Diabetes Mellitus.Tungkai bawah terutama kakisering bermasalah akibatnya perfusi jaringan bagian distal dari tungkai menjadi kurang baik dan timbul ulkus yang dapat berkembang menjadi nekrosis/gangren.Tujuan penelitian untuk menjelaskanpengaruh senam kaki DM terhadap perubahan nadi dorsalis pedis.
Penelitian menggunakan Quasy-experimentalpre-post test design. Populasi penelitian ini berjumlah 30 responden yang terbagi dalam kelompok perlakuan dan kontrol. Analisis data menggunakan Wilcoxon sign ranked test untuk 2 sampel berpasangan, dan mann whitney test untuk 2 sampel bebas.
Hasil uji pre test Mann-Whitneytestnilai p = 0.417sedangkan uji post test Mann-Whitneynilai p = 0.003. Hasil uji pre-post test kelompok perlakuan menggunakan Wilcoxon Signed ranked nilai p = 0.008sedangkan uji pre-post test kelompok kontrol menggunakan Wilcoxon Signed ranked nilai p = 0.564. Hasil penelitian ini menunjukkanada pengaruh senam kaki DM terhadap perubahan nadi dorsalis pedis.
Senam kaki DM yang dilaksanakan minimal 3 kali seminggu dalam jangka waktu 3 minggu terbukti memberikan pengaruh pada vaskularisasi perifer dan kestabilan glukosa darah. Senam meningkatkan Nitric Oxode Syntesis dan vasodilatasi arteri.Saran penelitian adalahmengembangkan model pencegahan impairmentulkus diabetikum berdasarkan teori keperawatan lainnya.
Magnetospheric Multiscale Observation of Kinetic Signatures in the Alfvén Vortex
Authors: Wang Tieyan , Alexandrova Olga , Perrone Denise , Dunlop Malcolm , Dong Xiangcheng , Bingham Robert , Khotyaintsev Yu. V. , Russell C. T. , Giles B. L. , Torbert R. B. , Ergun R. E. , Burch J. L. 
Published: January 2019

Abstract
Alfvén vortex is a multiscale nonlinear structure that contributes to the intermittency of turbulence. Despite previous explorations mostly on the spatial properties of the Alfvén vortex (i.e., scale, orientation, and motion), the plasma characteristics within the Alfvén vortex are unknown. Moreover, the connection between the plasma energization and the Alfvén vortex still remains unclear. Based on high-resolution in situ measurements from the Magnetospheric Multiscale mission, we report for the first time distinctive plasma features within an Alfvén vortex. This Alfvén vortex is identified as being a 2D (

) quasi-monopole with a radius of 10 proton gyroscales. Its magnetic fluctuations

are anti-correlated with velocity fluctuations

, thus the parallel current density

and flow vorticity

are anti-aligned. In different part of the vortex (i.e., edge, middle, center), the ion and electron temperatures are found to be quite different and they behave in the reverse trend: the ion temperature variations are correlated with

, while the electron temperature variations are correlated with

. Furthermore, the temperature anisotropies, together with the non-Maxwellian kinetic effects, exhibit strong enhancement at peaks of

within the vortex. Comparison between observations and numerical/theoretical results are made. In addition, the energy-conversion channels and the compressibility associated with the Alfvén vortex are discussed. These results may help to understand the link between coherent vortex structures and the kinetic processes, which determines how turbulence energy dissipates in the weakly collisional space plasmas.
Primary Congenital Glaucoma: 2004 Update
Authors: Ho Ching Lin , Walton David S. 
Published: January 2019

Educational Objectives

1.
To review current and new information of clinical value related to primary congenital glaucoma, including its genetic etiology, defining clinical features, and medical and surgical treatments.

2.
To describe the clinical evaluation of patients with childhood glaucoma and the differential diagnosis of patients with signs and symptoms that suggest primary congenital glaucoma.

3.
To describe the terminology, epidemiology, and pathogenesis of primary congenital glaucoma.

See quiz on page 300; no payment required.

Background:
Primary congenital glaucoma is the most frequent childhood glaucoma and an important cause of blindness. We describe the current understanding regarding this disease, the evaluation of children with it, and its treatment.

Patients and Methods:
We accessed information derived from a review of 287 patients with primary congenital glaucoma and current published data related to primary congenital glaucoma.

Results:

The nomenclature for childhood glaucoma has been inconsistent, but is clarified for children with primary congenital glaucoma. The epidemiology of primary congenital glaucoma notes its variable incidence worldwide. Familial occurrence supports autosomal recessive transmission; chromosomal loci have been identified, and the
CYP1B1
gene has been identified and clinically correlated. The histopathology of eyes with primary congenital glaucoma confirms the presence of a variable trabecular meshwork anomaly and the absence of an imperforate membrane. Children with primary congenital glaucoma are diagnosed after recognition of corneal signs and symptoms of glaucoma.

Conclusions:
The examinations of patients with primary congenital glaucoma must be thorough to distinguish this glaucoma from other types of childhood glaucoma, to prepare for surgery, and to follow progress with treatment. Medical treatment must be tailored to the pediatric patient. Goniosurgery is the definitive procedure of choice for most children with primary congenital glaucoma, but other procedures are also used successfully after goniosurgery fails or is determined to be inappropriate. Future success will be determined by physicians who sustain continued progress for children with glaucoma.

J Pediatr Ophthalmol Strabismus
2004;41:271–288.
Evidencias arqueológicas de un monasterio de los siglos VI-VII en el Prepirineo catalán: Santa Cecilia de Els Altimiris
Authors: Planas Marta Sancho i 
Published: January 2019

La excavación del yacimiento de Els Altimiris ha sacado a la luz un establecimiento monástico correspondiente al período visigodo (ss. VI-VII) enclavado en una zona montañosa del Prepirineo catalán. La comprensión e interpretación de las evidencias arqueológicas nos ha llevado a indagar sobre la estructuración del territorio pirenaico durante ese período, las características y procedencia de sus pobladores, la presencia de élites y las bases de su economía. Presentamos los resultados de nuestra investigación basada en el registro arqueológico de dicho yacimiento, contextualizado a partir de las investigaciones realizadas sobre este período en los últimos años. El objetivo es el de ofrecer una propuesta interpretativa que nos permita comprender las causas de la formación de este establecimiento así como las que originaron su decadencia a partir del siglo VIII y su total abandono a inicios del siglo IX.
Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis
Authors: Mancini Mathieu , Caignard Grégory , Charbonneau Benoît , Dumaine Anne , Wu Nila , Leiva-Torres Gabriel A. , Gerondakis Steve , Pearson Angela , Qureshi Salman T. , Sladek Robert , Vidal Silvia M. 
Published: January 2019

Abstract
Herpes simplex encephalitis (HSE), caused by HSV type 1 (HSV-1) infection, is an acute neuroinflammatory condition of the CNS and remains the most common type of sporadic viral encephalitis worldwide. Studies in humans have shown that susceptibility to HSE depends in part on the genetic make-up of the host, with deleterious mutations in the TLR3/type I IFN axis underlying some cases of childhood HSE. Using an in vivo chemical mutagenesis screen for HSV-1 susceptibility in mice, we identified a susceptible pedigree carrying a causal truncating mutation in the Rel gene (RelC307X), encoding for the NF-κB transcription factor subunit c-Rel. Like Myd88−/− and Irf3−/− mice, RelC307X mice were susceptible to intranasal HSV-1 infection. Reciprocal bone marrow transfers into lethally irradiated hosts suggested that defects in both hematopoietic and CNS-resident cellular compartments contributed together to HSE susceptibility in RelC307X mice. Although the RelC307X mutation maintained cell-intrinsic antiviral control, it drove increased apoptotic cell death in infected fibroblasts. Moreover, reduced numbers of CD4+CD25+Foxp3+ T regulatory cells, and dysregulated NK cell and CD4+ effector T cell responses in infected RelC307X animals, indicated that protective immunity was also compromised in these mice. In the CNS, moribund RelC307X mice failed to control HSV-1 viral replication in the brainstem and cerebellum, triggering cell death and elevated expression of Ccl2, Il6, and Mmp8 characteristic of HSE neuroinflammation and pathology. In summary, our work implicates c-Rel in both CNS-resident cell survival and lymphocyte responses to HSV-1 infection and as a novel cause of HSE disease susceptibility in mice.
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility
Authors: Bulek Katarzyna , Chen Xing , Parron Vandy , Sundaram Aparna , Herjan Tomasz , Ouyang Suidong , Liu Caini , Majors Alana , Zepp Jarod , Gao Ji , Dongre Ashok , Bodaszewska-Lubas Malgorzata , Echard Arnaud , Aronica Mark , Carman Julie , Garantziotis Stavros , Sheppard Dean , Li Xiaoxia 
Published: January 2019

Abstract
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type–specific deletion of IL-17R and adaptor Act1, we demonstrated that IL-17R/Act1 exerts a direct impact on the contraction of airway smooth muscle cells (ASMCs). Mechanistically, IL-17A induced the recruitment of Rab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/Act1 complex in ASMCs, resulting in activation of Rab35. Rab35 knockdown showed that IL-17A–induced Rab35 activation was essential for protein kinase Cα (PKCα) activation and phosphorylation of fascin at Ser39 in ASMCs, allowing F-actin to interact with myosin to form stress fibers and enhance the contraction induced by methacholine. PKCα inhibitor or Rab35 knockdown indeed substantially reduced IL-17A–induced stress fiber formation in ASMCs and attenuated IL-17A–enhanced, methacholine-induced contraction of airway smooth muscle. Taken together, these data indicate that IL-17A promotes airway smooth muscle contraction via direct recruitment of Rab35 to IL-17R, followed by PKCα activation and stress fiber formation.
Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus
Authors: Blundell Patricia A. , Lu Dongli , Wilkinson Mark , Dell Anne , Haslam Stuart , Pleass Richard J. 
Published: January 2019

Abstract
In therapeutic applications in which the Fc of IgG is critically important, the receptor binding and functional properties of the Fc are lost after deglycosylation or removal of the unique Asn297 N-X-(T/S) sequon. A population of Fcs bearing sialylated glycans has been identified as contributing to this functionality, and high levels of sialylation also lead to longer serum retention times advantageous for therapy. The efficacy of sialylated Fc has generated an incentive to modify the unique N-linked glycosylation site at Asn297, either through chemical and enzymatic methods or by mutagenesis of the Fc, that disrupts the protein–Asn297 carbohydrate interface. In this study, we took an alternative approach by inserting or deleting N-linked attachment sites into the body of the Fc to generate a portfolio of mutants with tailored effector functions. For example, we describe mutants with enhanced binding to low-affinity inhibitory human Fcγ and glycan receptors that may be usefully incorporated into existing Ab engineering approaches to treat or vaccinate against disease. The IgG1 Fc fragments containing complex sialylated glycans attached to the N-terminal Asn221 sequon bound influenza virus hemagglutinin and disrupted influenza A–mediated agglutination of human erythrocytes.
Identificação de comportamentos alimentares, tempo em frente à televisão e atividades físicas de adolescentes
Authors: Klouck Francielle , Farias Joni Márcio de , Pereira Eduarda Valim , Viero Vanise Dos Santos Ferreira 
Published: January 2019

Objetivo: Identificar os comportamentos relacionados aos hábitos alimentares, às atividades físicas, ao tempo em frente à tela de televisão (TV) e ao deslocamento ativo de adolescentes. Métodos: Estudo transversal, realizado em escola estadual do município de Praia Grande, Santa Catarina, Brasil. A amostra foi composta por 86 adolescentes, de ambos os sexos, com idade entre 14 a 19 anos, matriculados no ensino médio. O instrumento de pesquisa utilizado foi elaborado a partir da composição de indicadores validados, composto por 30 perguntas objetivas sobre dados sociodemográficos, hábitos alimentares e de atividades físicas, deslocamento ativo e tempo em frente à tela. Os dados foram tabulados no SPSS, versão 21.0, avaliando frequência absoluta, relativa, média, desvio padrão, teste t de Student e correlação “r” de Pearson, adotando-se o nível de significância de 95% (p≤0,05). Resultados: Dos 86 adolescentes, 40,7% relataram que raramente consomem uma dieta balanceada, 53,5% têm como lazer preferido as atividades físicas, 33,7% deslocam-se a pé para a escola e 31,4% utilizam a bicicleta. Referente ao tempo em frente à tela, meninos têm maior exposição (8h e 10h) do que as meninas (5h e 6h) em dias de semana e finais de semana, respectivamente. Conclusão: As características geográficas, as atividades físicas habituais e a segurança pública contribuem para um estilo de vida saudável no contra turno, exceto nos hábitos alimentares, indicando a necessidade do estabelecimento de estratégias que estimulem nesses jovens a adoção de hábitos saudáveis de vida.
Stable carbon and nitrogen isotopic composition of leaves, litter, and soils of various ecosystems along an elevational and land-use gradient at Mount Kilimanjaro, Tanzania
Authors: Gerschlauer Friederike , Saiz Gustavo , Schellenberger Costa David , Kleyer Michael , Dannenmann Michael , Kiese Ralf 
Published: January 2019

Abstract. Variations in the stable isotopic composition of carbon (δ13C)
and nitrogen (δ15N) of fresh leaves, litter, and topsoils were
used to characterize soil organic matter dynamics of 12 tropical
ecosystems in the Mount Kilimanjaro region, Tanzania. We studied a total of
60 sites distributed along five individual elevational transects
(860–4550 m a.s.l.), which define a strong climatic and land-use gradient
encompassing semi-natural and managed ecosystems. The combined effects of
contrasting environmental conditions, vegetation, soil, and management
practices had a strong impact on the δ13C and
δ15N values observed in the different ecosystems. The relative
abundance of C3 and C4 plants greatly determined the
δ13C of a given ecosystem. In contrast, δ15N
values were largely controlled by land-use intensification and climatic
conditions. The large δ13C enrichment factors
(δ13Clitter − δ13Csoil) and low soil C∕N ratios observed
in managed and disturbed systems agree well with the notion of altered SOM
dynamics. Besides the systematic removal of the plant biomass characteristic of
agricultural systems, annual litterfall patterns may also explain the
comparatively lower contents of C and N observed in the topsoils of these
intensively managed sites. Both δ15N values and calculated
δ15N-based enrichment factors
(δ15Nlitter − δ15Nsoil) suggest the tightest nitrogen cycling at
high-elevation (> 3000 m a.s.l.) ecosystems and more open
nitrogen cycling both in grass-dominated and intensively managed cropping
systems. However, claims about the nature of the N cycle (i.e. open or closed)
should not be made solely on the basis of soil δ15N as other
processes that barely discriminate against 15N (i.e. soil nitrate
leaching) have been shown to be quite significant in Mount Kilimanjaro's forest
ecosystems. The negative correlation of δ15N values with soil
nitrogen content and the positive correlation with mean annual temperature
suggest reduced mineralization rates and thus limited nitrogen availability,
at least in high-elevation ecosystems. By contrast, intensively managed
systems are characterized by lower soil nitrogen contents and warmer
conditions, leading together with nitrogen fertilizer inputs to lower
nitrogen retention and thus significantly higher soil δ15N
values. A simple function driven by soil nitrogen content and mean annual
temperature explained 68 % of the variability in soil δ15N
values across all sites. Based on our results, we suggest that in addition to
land-use intensification, increasing temperatures in a changing climate may
promote soil carbon and nitrogen losses, thus altering the otherwise stable
soil organic matter dynamics of Mount Kilimanjaro's forest ecosystems.
Conexión a la Comunidad: Latinx LGBT Feelings of Connectedness
Authors: Battle Juan , Peterson Robert B. 
Published: January 2019

Abstract
Over the past decade, progress among LGBT Americans has been impressive. However, are all subgroups experiencing that process equally? More specifically, for example, how connected to the larger/majority (white) LGBT community do Latinx LGBTs feel? Using a national sample of LGBT Latinx people (N=1,159), this article examines the relative importance of a variety of characteristics in understanding connectedness to the larger LGBT community. Hierarchical regression modeling reveals that racial salience and comfort in the LGBT community, LGBT activism, sexual orientation identity, nativity, and city residency all have a significant impact. The implications of these findings are discussed regarding future research with Latinx LGBT populations.
“White folks ain’t got hair like us”: African American Mother–Daughter Hair Stories and Racial Socialization
Authors: Wilson Ingrid-Penelope , Mbilishaka Afiya M. , Lewis Marva L. 
Published: January 2019

Abstract
Limited research focuses on the memories that shape African American mother–daughter bonds and racial socialization. Informed by Marva L. Lewis’s hair-combing interaction paradigm that emphasizes the role of hair in African American mother–daughter relationships, this study analyzes qualitative data from 13 African American female college students to explore mother–daughter dynamics, race, and hair. Multiple experiential themes emerged in the data: recognizing differences in hair texture, making doll choices, and daughters requesting permission from mothers to alter their hair chemically. Participants identified being between the ages of four to 14 years old during the experiences and expressed a range of feelings that centered on sadness, anger, and confusion. The findings address an indisputable void in understanding the internalized stories about hair that shape African American racial identity and racial socialization.
Tehnike reanimacije obraza glede na trajanje pareze obraznega živca
Authors: Vujkovac Ana Katarina , Božikov Krešimir 
Published: January 2019

Pareza obraznega živca ima lahko za bolnika hude posledice, ki se kažejo kot iznakaženost obraza, in funkcionalne motnje, ki kot take vplivajo tudi na duševno zdravje. Zdravljenje pareze je odvisno od vzroka zanjo. Ob ugotovitvi, da je pareza dokončna in izboljšanja ni pričakovati, se v plastični in rekonstruktivni kirurgiji poslužujemo različnih tehnik reanimacije obraza.
Za katere posege se bomo odločili, je ključnega pomena obdobje trajanja pareze, ki ga delimo na akutno, intermediarno in kronično. Glede na ta podatek se odločamo, kateri rekonstruktivni poseg je za bolnika najbolj primeren in pri katerem lahko pričakujemo najboljši rezultat. V članku so tehnike reanimacije za vsako obdobje natančno opisane.
Pri nas je bilo v obdobju med letoma 2008 in 2017 na Kliničnem oddelku za plastično, rekonstruktivno in estetsko kirurgijo in opekline UKC Ljubljana zaradi pareze obraznega živca obravnavanih 66 bolnikov, pri katerih so bili opravljeni opisani posegi. V članku je tudi predstavljena naša dosedanja statistika.
Poleg pravilne izbire in izvedbe kirurškega posega je pri parezi obraznega živca potrebno poudariti predvsem pomembnost zgodnje prepoznave in napotitve bolnikov v usmerjene specialistične centre, kjer so deležni individualne in celostne obravnave.
Appropriate or anathema? The representation of incest in children’s literature
Authors: Mills Alice 
Published: January 2019

The chapter draws attention to the extreme unspeakability of incest in children’s literature and the rarity of texts either literally or symbolically dealing with the topic. It analyses Crew and Scott’s picture story book, In My Father’s Room (2000), in terms of the Bluebeard fairy tale, with close attention to ways of seeing and being seen. This disturbing text (marketed as a book for young children) plays a father’s love for his daughter, manifested in his secret story-writing, against the Bluebeard story of secrecy, multiple sexual partners and murder. The boundaries of the unspeakable in literature for children have changed markedly in the post-war era, particularly in terms of problem novels for a young adult readership; but picture story books for younger readers remain almost uniformly committed to a depiction of the loving nuclear family with mother, father and child or children, where childhood naughtiness is the worst evil that can be encountered; incestuous behaviours by a father are barely mentionable and the incestuous mother unthinkable.