bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Daftar Kehadiran Mahasiswa Berbasis Kartu RFID Di Universitas Tanri Abeng
Authors: . Muhtar 
Published: November 2024

Memasuki Era Pandemi dari Covid-19 membuat perguruan tinggi perlu mengikuti protokol kesehatan yang telah diberikan oleh pemerintah. Salah satu kegiatan yang dilakukan penyesuaian untuk menghindari kontak fisik adalah saat pengisian daftar hadir tanpa melakukan kontak fisik. Pada beberapa perguruan tinggi masih melakukan pengisian daftar hadir secara konvensional, yaitu dengan memanggil satu persatu mahasiswanya atau dengan menandatangani daftar kehadiran pada secarik kertas secara bergilir. Selain menjaga jarak dengan tidak melakukan kontak fisik, tindakan pencegahan awal dari Covid-19 adalah pengecekan suhu tubuh. Suhu tubuh normal manusia terletak pada rentang 36,5 derajat Celsius hingga 37 derajat Celsius. Dalam penelitian ini penulis merancang dan menguji prototipe sistem daftar hadir menggunakan RFID dan sensor suhu Non-Contactless yang terhubung dengan web. RFID dan sensor suhu Non-Contactless digunakan untuk membatasi kontak fisik pada perguruan tinggi, sehingga penularan Covid-19 bisa dicegah. Berdasarkan hasil penelitian ini, pembaca RFID dapat membaca kartu mahasiswa (RFID Tag) pada jarak optimal 3 cm, sedangkan pembacaan suhu pada jarak optimal 1-5 cm. Ketika RFID Tag didekatkan pada pembaca RFID, kecepatan waktu pembacaan yang diperlukan adalah 1-10 detik, tergantung dengan kecepatan server web dan koneksi internet pada Wifi yang terhubung pada NodeMCU.
Anaerobic membrane bioreactor (AnMBR) with external ultrafiltration membrane for the treatment of sugar beet vinasse
Authors: Bueno Beatriz Egerland , Muniz Brito André Luiz , Garcia Rea Victor. S. , Kurnianto Rifki Wahyu , Zaiat Marcelo , van Lier Jules. B. 
Published: November 2024

Vinasse, a by-product of ethanol production, is generated at significant rates. While rich in nutrients such as calcium, magnesium, and potassium, its high solids, organic matter, acidity, and sulfate content pose challenges when disposed directly on soil, necessitating treatment. Anaerobic digestion is a viable solution, reducing organic pollution while recovering energy in the form of biogas, aligning with the biorefinery concept. Traditionally, sludge bed reactors and anaerobic contact reactors are utilized for vinasse processing, with sludge granulation being vital for treatment success. However, challenges such as sludge wash-out due to recalcitrant compounds, high solids concentration in the influent, low pH, salinity, and temperature hinder granule formation. Anaerobic membrane bioreactors (AnMBR) offer an alternative, simplifying treatment by integrating intensified pre- and post-treatment units. Due to complete sludge retention, AnMBRs achieve high COD removal efficiencies, yielding a suspended solids-free and largely disinfected effluent. Therefore, AnMBRs show promise for vinasse treatment, eliminating the need for sludge granulation and producing nutrient-rich effluent with minimal residual organics and suspended solids. In this study, an AnMBR equipped with an inside-out external crossflow ultrafiltration membrane was proposed for the treatment of vinasse. The AnMBR reached a COD removal efficiency of 95% ± 2.6% and produced 0.3 CH4 L. g COD removed-1 working at organic loading rates of 8 g COD. L-1 d-1 and membrane fluxes of 10 LMH. At organic loading rates of 10 g COD. L-1 d-1 and fluxes of 12 and 14 LMH, the COD removal efficiency decreased to 77% ± 11% and 73% ± 7.9%, respectively. The AnMBR technology represents an innovation for wastewater treatment, however, more research using the cross-flow configuration and different types of effluents is needed. Literature studies that address the treatment of sugar beet or sugarcane vinasse using AnMBR are still scarce. This study explored the potentials of AnMBR technology for vinasse treatment and contributes to the dissemination of this technology, opening new possibilities for vinasse processing.
Association of cumulative non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with the risk of cardiometabolic disease
Authors: Liu Luqing , Liu Shihe , Liao Yicheng , Zhang Xiaoxue , Wang Meixiao , Lin Liming , Zhu Chenrui , Wu Shouling , Wu Yuntao 
Published: November 2024

BackgroundOne measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovascular disease (CVD) risk. This study aimed to exploring the association between cumulative non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (Cum NHHR) exposure levels and the risk of cardiometabolic disease (CMD).MethodsThis prospective cohort study included 43,735 participants, who participated in three consecutive health examinations in 2006, 2008, 2010 and had no history of CMD or cancer. The participants were divided into quartiles bases on their cum NHHR. Multivariate Cox proportional hazards model was used to assess the association between cum NHHR and the risk of CMD. Additionally, the direct method of standardized ratios was employed to calculate the absolute risk of CMD attributable to cum NHHR.ResultsOver a median follow-up period of 10.92 years (IQR: 10.22–11.26 years), 7,388 participants were newly diagnosed with CMD. In the multivariate-adjusted model, participants in quartiles Q2, Q3 and Q4 showed a progressively increased relative risk of CMD compared to those in Q1, The fully adjusted hazard ratios (95% confidence intervals) for the risk of CMD in the Q2, Q3, and Q4 groups were 1.11 (1.04–1.20), 1.23 (1.14–1.32), and 1.29 (1.20–1.38), respectively, compared with the Q1 group. This association remained significant even after further adjustment for single measurements of NHHR. Moreover, cum NHHR was positively correlated with the absolute risk of CMD, cardiovascular diseases (CVD), and type 2 diabetes (T2DM).ConclusionsHigher cum NHHR is significantly associated with an increased risk of CMD, independent of single-point NHHR level. Additionally, there are significant different strengths of correlations between cum NHHR and different diseases.
The diurnal pattern of cytokines, chemokines and growth factors in human saliva—a pilot study
Authors: Jasim Hajer , Ghafouri Bijar , Ernberg Malin 
Published: November 2024

BackgroundUnderstanding of possible periodicity of cytokines, chemokines and growth factors is of great interest and provide valuable information for research into pathophysiological mechanism of inflammatory disease and chronic pain. Significant efforts have been made to identify different analytes in saliva. For precision and accuracy in measurement and interpretation of results, it is crucial to know the source of variability, especially the circadian variation for the analytes.ObjectiveThe study aimed to analyze circadian variation in 71 inflammatory markers in both unstimulated and stimulated saliva, as well as plasma, from a sample of healthy individuals.MethodsTen young adults participated. Unstimulated and stimulated whole saliva were collected at 3-h intervals between between 7:30 am and 7:30 pm. Blood samples were drawn in connection with the first and last saliva collection. All samples were analyzed using the U-PLEX 71-Plex assay.ResultsThe analysis showed distinct clustering of the 71 inflammatory mediators between plasma and saliva. Furthermore, differences were also observed between stimulated and unstimulated saliva. The proteins were clustered into three groups that expressed different circadian rhythms. These clusters were stable over time in stimulated saliva but showed significant variability in unstimulated saliva (P &lt; 0.05).ConclusionsThese results suggest that time of the day could influence the detection and interpretation of inflammatory markers and collecting saliva samples at consistent times across participants will help control for the natural fluctuations in salivary composition. The results encourage further exploration of salivary diagnostics, particularly in understanding circadian rhythms and localized immune responses.
Joint association of METS-IR and uric acid with stoke, mediated by C-reactive protein
Authors: Jiang Shan , Zhang Xinyi , Song Chengning , Wu Guangfu , Yang Aicheng 
Published: November 2024

ObjectivesTo explore the dose-response relationship between the Metabolic Score of Insulin Resistance (METS-IR), uric acid (UA) and the risk of stroke incidence, the mediating role of C-reactive protein (CRP) in the above relationship, as well as the joint effect of METS-IR and UA on the risk of stroke incidence.MethodsParticipants from the CHARLS study were included in this cohort study. Logistic regression models were used to estimate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the associations of METS-IR and UA with the risk of incident stroke. The dose-response relationships of METS-IR and UA with stroke risk were assessed by restricted cubic spline regression. The mediation models were employed to estimate the potential mediating effects of CRP on the associations of METS-IR and UA with stroke risk. Logistic regression analysis was carried out to analyse the association of stroke and MRTS-IR combined with UA.ResultDuring a 9-year follow-up from 2011 to 2018, 570 incident cases of stroke were documented among 7,343 total participants. Per interquartile range increases in METS-IR and UA were associated with the increased risk of incident stroke, with the OR (95% CI) of 1.61 (1.44, 1.80) and 1.18 (1.05, 1.32) respectively. A dose-response function showed that METS-IR had a nonlinear relationship (P for nonlinear=0.047) and UA had a linear relationship (P for nonlinear=0.247) with the stroke risk. CRP had significant mediated effects on the associations of METS-IR and UA with stroke risk, and the proportion of mediation was 9.01% and 26.34% respectively (all P &lt; 0.05). The results of joint effect showed that participants with high levels of METS-IR and UA had the highest increased risk of stroke compared to the participants with low levels of METS-IR and UA.ConclusionMETS-IR and UA levels were positively associated with an increased risk of stroke onset, and CRP mediated these relationships. Improving insulin sensitivity and regulating CRP and uric acid levels may be important for preventing the risk of stroke occurrence.
Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations
Authors: de Sousa Ashelley Kettyllem Alves , Pires Keyla Silva Nobre , Cavalcante Isadora Hart , Cavalcante Iasmin Cristina Lira , Santos Julia Domingues , Queiroz Maiara Ingrid Cavalcante , Leite Ana Catarina Rezende , Crispim Alessandre Carmo , da Rocha Junior Edmilson Rodrigues , Aquino Thiago Mendonça , Weingrill Rodrigo Barbano , Urschitz Johann , Ospina-Prieto Stephanie , Borbely Alexandre Urban 
Published: November 2024

IntroductionMicroplastics (MPs) are environmental pollutants that pose potential risks to living organisms. MPs have been shown to accumulate in human organs, including the placenta. In this study, we investigated the biochemical impact of 5 μm polystyrene microplastics (PS-MPs) on term placental chorionic villi explants, focusing on cytotoxicity, oxidative stress, metabolic changes, and the potential for MPs to cross the placental barrier.MethodsTerm placental chorionic explants were cultured for 24 hours with varying concentrations of PS-MPs, with MTT assays used to determine the appropriate concentration for further analysis. Cytotoxicity was assessed using the lactate dehydrogenase (LDH) release assay over a period of up to 72 hours. Reactive oxygen species formation and antioxidant activity were evaluated using biochemical assays. Metabolomic profiling was performed using proton nuclear magnetic resonance (1H NMR).ResultsPlacental explants exposed to 100 μg/mL of PS-MPs showed a significant increase in cytotoxicity over time (p &lt; 0.01). Levels of mitochondrial and total superoxide anion (p &lt; 0.01 and p &lt; 0.05, respectively) and hydrogen peroxide (p &lt; 0.001) were significantly elevated. PS-MP exposure resulted in a reduction in total sulfhydryl content (p &lt; 0.05) and the activities of antioxidant enzymes superoxide dismutase (p &lt; 0.01) and catalase (p &lt; 0.05), while glutathione peroxidase activity increased (p &lt; 0.05), and the oxidized/reduced glutathione ratio decreased (p &lt; 0.05). Markers of oxidative damage, such as malondialdehyde and carbonylated proteins, also increased significantly (p &lt; 0.001 and p &lt; 0.01, respectively), confirming oxidative stress. Metabolomic analysis revealed significant differences between control and PS-MP-exposed groups, with reduced levels of alanine, formate, glutaric acid, and maltotriose after PS-MP exposure.DiscussionThis study demonstrates that high concentrations of PS-MPs induce time-dependent cytotoxicity, oxidative stress, and alterations in the TCA cycle, as well as in folate, amino acid, and energy metabolism. These findings highlight the need for further research to clarify the full impact of MP contamination on pregnancy and its implications for future generations.
The therapeutic effects of curcumin on polycystic ovary syndrome by upregulating PPAR-γ expression and reducing oxidative stress in a rat model
Authors: Zhang Wei , Peng Cong , Xu Lei , Zhao Yutai , Huang Chaolin , Lu Ling 
Published: November 2024

ObjectivePolycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that impacts 8-13% of women in their reproductive years. However, the drugs commonly used to treat PCOS are often prescribed off-label and may carry potential side effects. This study aimed to investigate the therapeutic effects of curcumin in a PCOS rat model.Materials and methodsA PCOS rat model was established through daily subcutaneous injection of 60 mg/kg body weight of dehydroepiandrosterone (DHEA) for 21 days. The PCOS rats received a daily intragastric dose of 50 mg/kg body weight of curcumin for another 21 days. Ovarian morphological changes, estrous cycle changes, and hormone level changes were measured to evaluate the therapeutic effectiveness of curcumin in PCOS rats. Oxidative stress markers in the ovaries were analyzed to explore the mechanisms of curcumin in PCOS rats.ResultsThis study demonstrated that curcumin alleviated insulin resistance and significantly reduced serum levels of estradiol (p = 0.02), luteinizing hormone (p = 0.009), testosterone (p = 0.003), and the LH/FSH ratio (p = 0.008) in PCOS rats. Curcumin also restored normal ovarian morphology and the estrous cycle in these rats. Furthermore, curcumin treatment significantly decreased levels of oxidative stress markers, including malondialdehyde (p = 0.004) and reactive oxygen species (p = 0.005), while increasing antioxidant levels such as superoxide dismutase (p = 0.04), glutathione peroxidase (p = 0.002), and glutathione (p = 0.02) in ovarian tissues. Additionally, curcumin significantly upregulated PPAR-γ in the ovarian tissues of PCOS rats.ConclusionThis study demonstrates that curcumin effectively restores ovarian morphology, hormone levels, and estrous cycles in PCOS rats. These effects may be linked to its ability to reduce oxidative stress in ovaries via the upregulation of PPAR-γ. Curcumin shows promise as a potential drug for the treatment of PCOS.
Identification and spatial pattern analysis of abandoned farmland in Jiangxi Province of China based on GF-1 satellite image and object-oriented technology
Authors: Liang Yang , Liang Yiwen , Tu Xiaosong 
Published: November 2024

IntroductionIndustrialization, urbanization, wars, and conflicts have caused farmland abandonment and exacerbated food security issues, posing a major challenge to global food security. Therefore, it is of great significance to monitor the status of crop abandonment in major grain-producing areas. Most of previous studies using remote sensing technology to extract abandoned farmland have small scale and low accuracy, and there was lack of large-scale studies using GF-1 image. Particularly in the Jiangxi Province, as the main grain-producing area of China, the situation of farmland abandonment is still unknown.MethodsIn this paper, GF-1 WFV remote sensing images are used as the main data source. A binary decision tree process based on the object-oriented technology classification and vector similarity function change detection methods are adopted to extract abandoned farmland information in Jiangxi Province during 2020–2022 and to describe its spatial pattern.ResultsThe results show that the overall accuracy of GF-1 remote sensing image extraction based on object-oriented technology is 93%, and the Kappa coefficient is 0.89. The abandoned farmland in Jiangxi Province covers an extensive area of 3.41 × 105 hm2, with an abandonment rate of 9.87%. Abandonment is greater in the north and less in the south, with a spatial distribution pattern characterized by sparse coverage in mountainous areas and aggregation in plains areas. Farmland abandonment is most severe in the areas surrounding the northern Poyang Lake Plain, and the degree of farmland abandonment varies significantly among various prefecture cities as well as among different counties. The highest rate of farmland abandonment in prefecture cities was 13.18% and the lowest was 7.13%. The highest rate of farmland abandonment in the county was 24.22%, and the lowest was 1.99%.DiscussionThe results are helpful in understanding the status of abandoned farmland in major grain-producing areas. It is believed they are significant for farmland protection and real-time national food security strategy.
Identifying climatically-compatible seedlots for the eastern US: building the predictive tools and knowledge to enable forest assisted migration
Authors: Adams Bryce T. , Royo Alejandro A. , Kern Christel C. , Bronson Dustin R. , Matthews Stephen N. , Gougherty Andrew V. , Prasad Anantha M. , Iverson Louis R. , Rehm Evan M. , Raymond Patricia , Périé Catherine , Miesel Jessica R. , McGraw Amanda M. 
Published: November 2024

IntroductionGlobal climate change and associated stressors threaten forest ecosystems due to the rapid pace of climate change, which could exceed the natural migration rate of some tree species. In response, there is growing interest to research and implement forest assisted migration (FAM). Here, we used a species-independent indicator based on climate analogy, according to the sigma (dis)similarity (σd) index, to match planting sites across the eastern US with (future) climatically-compatible seedlots (CCS).MethodsWe developed CCS for a grid composed of 1 × 1° of latitude and longitude. CCS were based on future climate analogs with ≤2σd analogy to ensure CCS were representative of future climate change. CCS were located for three time periods, 2030's, 2050's, and 2090's and three emissions scenarios (SSP2-4.5, SSP3-7.0, and SSP5-8.5) from the Coupled Model Intercomparison Project phase 6 database, using 12 climate variables.ResultsCCS were identified for the majority of 1 × 1° grids based on the SSP3-7.0 scenario. Approximately 28% of 1 × 1° grid's 2090's projections included future climate novelty. The 2030's, 2050's, and 2090's CCS were located on average 222, 358, and 662 km or 1, 2, and 3 eastern seed zones away from the 1 × 1° grids, respectively. CCS were also located further south-southwest (188–197°). In addition, the average forest cover of CCS was approximately 2%, 5%, and 10% less than that of the 1 × 1° grids.DiscussionOur development and synthesis of CCS emphasized four key results: (i) average distances to 2030's and 2050's CCS were similar to seed-transfer guidelines for some tree species, but 2090's CCS exceeded current recommendations; (ii) south-southwesterly locations of CCS aligned with tree species habitat distribution dynamics; (iii) future climate novelty potentially challenges the conceptual basis of FAM if tree species are not adapted to climate change; and (iv) variation in forest cover among CCS presents potential opportunities and challenges due the presence or absence of forestland to source seed. Ultimately, our goal was to locate and synthesize CCS that could enable FAM decision support.
The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI
Authors: Rehman Rida , Froehlich Albrecht , olde Heuvel Florian , Elsayed Lobna , Boeckers Tobias , Huber-Lang Markus , Morganti-Kossmann Cristina , Roselli Francesco 
Published: November 2024

BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines. Several receptor tyrosine kinases (RTK) are activated in microglia upon TBI, and their blockade may reduce the acute inflammation and decrease the secondary loss of neurons; thus, RTKs are potential therapeutic targets. We have previously demonstrated that several members of the Fibroblast Growth Factor Receptor (FGFR) family are transiently phosporylated upon TBI; the availability for drug repurposing of FGFR inhibitors makes worthwhile the elucidation of the role of FGFR in the acute phases of the response to TBI and the effect of FGFR inhibition.MethodsA closed, blunt, weight-drop mild TBI protocol was employed. The pan-FGFR inhibitor Rogaratinib was administered to mice 30min after the TBI and daily up to 7 days post injury. Phosphor-RTK Arrays and proteomic antibody arrays were used to determine target engagement and large-scale impact of the FGFR inhibitor. pFGFR1 and pFGFR3 immunostaining were employed for validation. As outcome parameters of the TBI injury immunostainings for NeuN, VGLUT1, VGAT at 7dpi were considered.ResultsInhibition of FGFR during TBI restricted phosphorylation of FGFR1, FGFR3, FGFR4 and ErbB4. Phosphorylation of FGFR1 and FGFR3 during TBI was traced back to Iba1+ microglia. Rogaratinib substantially dowregulated the proteomic signature of the neuroimmunological response to trauma, including the expression of CD40L, CXCR3, CCL4, CCR4, ILR6, MMP3 and OPG. Prolonged Rogaratinib treatment reduced neuronal loss upon TBI and prevented the loss of excitatory (vGLUT+) synapses.ConclusionThe FGFR family is involved in the early induction of reactive microglia in TBI. FGFR inhibition selectively prevented FGFR phosphorylation in the microglia, dampened the overall neuroimmunological response and enhanced the preservation of neuronal and synaptic integrity. Thus, FGFR inhibitors may be relevant targets for drug repurposing aimed at modulating microglial reactivity in TBI.