bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cloxacillin on Bilirubin-albumin Binding
Authors: Surjono Achmad 
Published: January 2019

Cloxacillin is usually given to newborn infants with sepsis in particular for penicillinase-producing staphylococcus aureus. The effect of cloxacillin on bilirubin-albumin binding was investigated in vitro using the peroxidase oxidation method with human albumin (bilirubin 0.255 mM, albumin 0.45 mM, billalb 0.56, pH 7.4, temperature 3 0°C). Sulfisoxazole, a drug which is capable of displacing bilirubin from albumin was used as control.
The displacement constant of cloxacillin was 4.86 x 1o5 Nr1, stronger than that of sulfisoxazole (1. 72 x 104 M-1). Both drugs were capable of displacing bilirubin as determined by their maximal displacement factors of 2.21 and 2.29, respectively. Since cloxacillin apparently increases the risk of bilirubin encephalopathy the use of this drug in jaundiced newborns with sepsis, especially in the premature infants, should be reconsidered.
Sweat sodium and chloride contents in 8-14 years old children (A preliminary study)
Authors: Boediman I. , Widodo Dwi P. , Rahajoe Noenoeng 
Published: January 2019

A modified Shwachman sweat test was performed on 152 children aged between 8-14 .4 years old, consisting of 54 girls (35.5%) and 98 boys (64%), to look for sweat electrolyte values. Mean sweat electrolyte contents in boys was higher than in girls. The mean sweat Na+ and Cl- were 50.15 ±25.83 mEq/L and 43 .76 m.Eq/l ± 24.67 respectively. The sweat electrolyte contents were not influenced by age.
Early protection against measles infection in children Immunized with DPT-measles Vaccine at the Age of 4 Months
Authors: Soegijanto Soegeng , Soejono Dwi Atmaji , B. Parwati Setiono 
Published: January 2019

A study on early immunization with DPT-measles vaccine at the age of 4 months, was earned out during 1990 - 1991 on 348 babies at the Health Centre of Surabaya regency. Three hundred and forty eight babies were served as control. The results of the study reported here were : (a) By giving a mixture of DPT and measles at an early age (4 months of age) the coverage of measles immunization could be increased to 21% - 27%. (b) 1'wenty two percents of measles cases could be prevented. (c) The geometric mean titer using hemagglutination inhibition test of the babies who got a mixture DP7~measles vaccination at an early age was significantly higher than that of the GMT HI test of babies who got measles vaccination at the age of 9 months ( z test, p <0, 05 ) .
The result of analysis of data showed that an early immunization program using a mixture of DPT-measles could protect babies under 9 months and thus prevent them from measles infection.
Bianciotti : une vie au fil des langues
Authors: Gachet Delphine 
Published: January 2019

1992 : l’académicien français d’origine argentine, Hector Bianciotti publie le premier volume d’une trilogie de textes qu’il qualifie d’ « autofictions », soulignant qu’ils marquent à la fois une continuité et une rupture. Continuité car l’Argentine a toujours alimenté son imaginaire. Rupture car il choisit l’autobiographie. Bianciotti, alors, découvre les caprices du souvenir : certains moments importants se sont effacés de sa mémoire quand certains détails anodins s’y sont imprimés. À partir de ce matériau fragmentaire, Bianciotti va (re)construire l’histoire de sa vie, de celui qu’il fut et qu’il n’est plus. Le sentiment de dédoublement alors n’est pas seulement l’œuvre du temps mais aussi celle de la langue. L’écrivain se sent appelé à relever un difficile pari : dire celui qu’il a été dans la langue de celui qu’il est, confier au français la tache de redécouvrir l’Argentin qu’il fut, qu’il a voulu renier, que pourtant il n’a jamais cessé d’être.
Carmelo Bene. Ricominciando dal tramonto del giorno.
Authors: Oppedisano Francesca Rachele 
Published: January 2019

Carmelo Bene coglie nella caduta residuale d’un frammento acustico involontario, letterario o poetico, estraneo al soggetto, la possibilità di dar vita a un’infinità di mondi impossibili. Attraverso la rielaborazione d’un accadimento che prende il soggetto costantemente impreparato, nella ripetizione d’una percezione costantemente rinnovata, l’attore, nell’atto del porsi in ascolto, scopre attraverso il dire che l’essere umano è condannato a trovar posto all’interno d’una esteriorità già data che lo precede, da sempre. Non resta dunque al nostro artefice che dribblare le direttive del senso imposte all’essere parlante, operare, all’interno di una sorta di fucina del senso, la materia di cui si compone la phoné, per invocare al grado ultimo della sua arte teatrale l’attenzione d’uno spettatore sordomuto che incapace di restituire l’inaudito è in grado di preservare l’assoluta purezza d’una voce esterna al soggetto che si dica senza intenzione: «Ah soltanto esser solo UNA VOCE!»
Rita Levi Montalcini
Authors: Barbalato Beatrice 
Published: January 2019

Tre tratti principalmente si rilevano negli scritti autobiografici di Rita Levi Montalcini : a) Il rapporto con la cultura umanistica : RLM impiega un vocabolario ricco di metafore letterarie e riferimenti pittorici quando spiega il suo lavoro scientifico ; b) la concezione di un temporalità differente per le humanitas e per il lavoro nelle scienze neurobiologiche : per la ricerca scientifica tesse l’elogio dell’imperfezione : la scienza è porosa, permeabile, contrariamente all’etica che è necessaria, non arbitraria ; c) all’etica RLM attribuisce un respiro lungo e duraturo, alla scienza una temporalità più breve, legata alla sperimentazione, e segnata dal fato.
Encomiando i compagni di percorso - tra cui Primo Levi - il loro impegno politico (in senso ampio), mai differito, il loro essere di roccia RLM li associa alla bellezza e cristallinità della poesia, evocando in Sott’olio contro vento Yeats, Rilke, e le composizioni poetiche degli stessi protagonisti di cui scrive. Il dialogo fra scienza e humanitas è il nucleo fondativo della visione che offre anche di se stessa.
MULTICULTURALISM IN EDUCATION INSTITUTION: STUDY ON MULTICULTURALISM PRACTICE IN WIJAYA KUSUMA ELEMENTARY SCHOOL LASEM – REMBANG
Authors: Amirudin Amirudin 
Published: January 2019

RESEARCH - is conducted to examine how multiculturalism is carried out in the field of educational. This research is intended to create a learning model that is able to produce multicultural products in Elementary School. Through ethnographic methods, this study found that the multiculturalism practice in SD Wijayakusuma had happened, it can be seen by the dynamic interaction between inclusive actors. Elementary school students are openly abled to interact others without distinguishing ethnicity, religion, race and class. They have relation just the way they are, self openess, all students can be friends with anyone and express themselves without fear of threats from any parties.Good interaction have been seen among students then create mutual appreciation and respect each others. In addition, this research also found that the factor that support multiculturalism creation in research locations such as: foundation policies and school’s key person who develop schools without any limitation of religion, ethnicity, culture, mutual appreciation and respectfull.Meanwhile, other supporting factors are: infrastructure facilities for extracurricular cross ethnic activities; school changing name, free uniforms on Friday, teacher who have a sense of tolerance toward student, non-discriminatory school rules, meetings or deliberation between school and parent, mix-cultural arts between Javanese and Chinese, celebrating religious holidays, helping each other in preparation for religious activities, as well as the people enthusiasm who were very enthusiastic about the school.Based on the findings, the researcher suggested: schools must provide more inclusive service space without discriminating between students. Improving the student facilities needed, holding joint activity that entertain community to show mutual appreciation and respect people each other. Even though they are different, they can still communicate each other. That’s why people put great expectation and abled give full support to the institutional of SD Wijayakusuma.
Model to predict the top-to-bottom compressive strength of folding cartons
Authors: Pyryev Yuriy , Zwierzyński Tomasz , Kibirkštis Edmundas , Gegeckienė Laura , Vaitasius Kęstutis 
Published: January 2019

Abstract
This paper presents a proposed mathematical model, describing the calculations involved in deducting the critical compression force for rectangular, parallelepiped paperboard packaging, and permitting the minimisation of the thickness of the package sidewall. A comparison is given between the obtained calculations regarding critical force and the experimentally-determined results. This has shown a sufficient level of accuracy both for the theoretical and the experimental results. This means that the proposed mathematical engineering calculations model can be applied to the design of rectangular, parallelepiped paperboard packaging.
Benificial effect of stachydrine on the traumatic brain injury induced neurodegeneration by attenuating the expressions of Akt/mTOR/PI3K and TLR4/NFκ-B pathway
Authors: Yu Nianzu , Hu Si , Hao Zheng 
Published: January 2019

Abstract
Present investigation aims to explore the protective effect of stachydrine against traumatic brain injury (TBI) and also investigate the molecular mechanism of its action. TBI was induced by the fall a hammer (450 g) from the height of 1.5 m. and later stachydrine was administered for 2 weeks starting 2 hr after the induction of TBI. Effect of stachydrine was determined by estimating modified neurological severity score (mNSS), percentage of water content in the brain and cognitive dysfunction in TBI rats. Moreover western blot assay, histopathology and enzyme linked immunosorbent assay (ELISA) tests were used to determine the effect of stachydrine on TBI injured rats. Result of the report suggests that stachydrine reduces the mNSS and percentage of water content in the brain and also attenuates the cognitive dysfunction in TBI injured rats. However data of western blot assay reports that stachydrine reduces the expression of PI3K/m-TOR/Akt pathway in the brain tissues of TBI rats. Concentration of interleukin (IL-1β), tumor necrosis factor-α (TNF-α) and interferon gamma (INF-γ) was reduces in stachydrine treated group than TBI group. Moreover expression of Nuclear factor-κB/Toll-like receptor 4 (NF-κB/TLR-4) protein was also decreased in stachydrine treated group than TBI group. Histopathology study on brain tissue reveals that the percentage of apoptotic cells was also reduced in stachydrine treated group than TBI group. Data of this investigation concludes that stachydrine protects the neuronal injury by attenuating the phosphatidylinositide 3-kinases/mammalian target of rapamycin/Protein kinase B (PI3K/m-TOR/Akt) and NF-κB/TLR-4 pathway in TBI injured rats.
Greening Canada’s Arctic food system: Local food procurement strategies for combating food insecurity
Authors: Chen Angel , Natcher David 
Published: January 2019

Across northern Canada community gardens and greenhouses are being used as alternatives to imported foods that are often unaffordable, are of compromised quality, or simply unavailable in local retail outlets. Community gardens and greenhouses are seen as part of the solution to lessen local reliance on costly nutrient-poor market foods imported from the south. In spite of their acknowledged benefits, research on community gardens and greenhouses in northern Canada, including their numbers and locations, remains sparse and anecdotal. The objectives of this research were to inventory and map community gardens and greenhouses in northern Canada, encompassing Labrador, Nunavik, Nunavut, Yukon, and the Northwest Territories. This inventory represents an initial stage of research that will determine the extent to which community gardens and greenhouses, as local procurement strategies, are meeting the food needs of northern residents. This research is part of a circumpolar research project supported by the Arctic Council’s Sustainable Development Working Group, which is examining the opportunities for the Arctic to become a self-sustaining food-producing region.
The Knowledge and Practices of Women of Child Bearing Age towards Safe Motherhood in Ekiti State
Authors: A.S. (Ph.D) Okhakhume , V.A Okhakhume 
Published: January 2019

Knowledge about safe motherhood practices could help reduce pregnancy related health risks. This study examined knowledge of safe motherhood among women of childbearing age in Ekiti state of Nigeria.
The study employed, a cross sectional descriptive research to investigate the knowledge, and practice of women of child bearing age towards safe mother-hood in Ekiti State. The target populations were women of child bearing age in the Public Health Institutions in Ekiti state.
The results revealed that the knowledge of safe motherhood practices among Child Bearing Mothers (CBMs) were considered adequate (77.9%). Also, the result further indicated that immunization practices of CBMs was excellently adequate (97.6%) since it met the above acceptable standard by WHO. Additionally, the nutritional practices among CBMs were considered adequate (77.2%). Further, the competency of the health personnel according to CBMs was very adequate (80.8%) since it met the above acceptable standard by WHO. Moreover, availability and accessibility of facilities for safe motherhood according to CBMs was a little above average (55.4%). The result further showed that maternal educational level had significant effect on all the safe motherhood practices, Knowledge of SM [F(5,157)=6.026, p<.001]; Nutritional practices of SM [F(5,157)=8.848, p<.001]; Immunization practices of SM [F(5,157)=12.366, p<.001]; Personal hygiene practice [F(5,157)=2.934, p<.05]; Competency of the health personnel [F(5,157)=6.913, p<.001]; Factors that determine underutilization of SM [F(5,157)=2.436, p<.05]; Availability and accessibility for SM [F(5,157)=4.331, p<.001] & Family planning practice of SM [F(5,157)=11.039, p<.001].
Based on the findings of the study, it was concluded that there were adequate knowledge of safe motherhood practices among CBMs in Ekiti State. Secondly, there were adequate nutritional practices among CBMs in Ekiti State. Thirdly, the immunization practices among CBMs in Ekiti State were excellently adequate. Finally, the personal hygiene practices among CBMs in Ekiti State were more than adequate. It was therefore recommended that health educators, institutions and other health professional should design better educational strategies to improve health education practices among CBMs in the area of study. Secondly, seminars and workshop should be organized for CBMs to improve their utilization of MCH services.
Role of Education of Diabetes to Controlling Plasma Glucose, BMI, Cholesterol, Blood Pressure in Central Hospital Nampula.
Authors: Varma MD Dr Madhumati 
Published: January 2019

Mozambique is located on the East Coast of Africa. In this country, obesity, poor knowledge regarding diabetes, and a lack of awareness of the complications of diabetes are prevalent. Furthermore, most of the population utilizes traditional healers for the treatment of diabetes. There are unhealthy food habits, a sedentary lifestyle in the urban population, and increased economic growth among office-related professions, which is one of the risk factors that cause diabetes and its complications. Currently, no study has been conducted for patients on the effects of education in various modalities of diabetes. Accordingly, there is an extreme need to educate diabetic patients to improve their control of diabetes and to reduce its complications. Adequate medical management and proper lifestyle measures should start directly at the time of the diagnosis of diabetes, which can result in the diabetic individual living a life just as cheerful as that of a non-diabetic person. However, this objective requires proper counselling of the patient specifically at the time of diagnosis, which can be achieved by well-planned educational programs that target the newly diagnosed diabetic individual and create awareness about diabetes. In central hospital Nampula in diabetic OPD, three education sessions were organized, at an interval of one month (baseline, first follow up and second follow up). Each participant was evaluated in each session regarding their BMI, blood pressure, plasma glucose, cholesterol concentrations. The statistical analysis showed strong significantly positive correlation effects with glucose to BMI, blood pressure, cholesterol on controlling each of these parameters. Prior to the commencement of the baseline education session, an evaluation of the evolution of patient knowledge regarding diabetes mellitus (the pretest) was performed. At the end of the second follow up, a posttest was performed, which showed strong significant increases in the knowledge of diabetes.
Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma
Authors: Harati Elham , Bahrami Maryam , Razavi Alireza , Kamalinejad Mohammad , Mohammadian Maryam , Rastegar Tayebeh , Sadeghipour Hamid Reza 
Published: January 2019

Asthma is a chronic inflammatory disease of the lungs driven by T cell activation. Viola tricolor L. as a traditional medical herb could suppress activated T lymphocytes and has been used empirically for asthma remedy. In the present study, we investigated the anti-inflammatory effect of Viola tricolor and its underlying mechanism on asthma characteristics induced by ovalbumin (OVA) in mice.
BALB/c mice were randomly divided into six groups: normal control, Ovalbumin (OVA) control, OVA mice treated with Viola tricolor (50, 100 and 200 mg/kg) and dexamethasone (3 mg/kg). All mice except normal controls were sensitized and challenged with OVA. Asthmatic mice were treated orally in the last 7 days of OVA challenge. The total and differential leukocyte counts, Interleukin (IL)-4 and interferon (IFN)-γ levels in bronchoalveolar lavage fluid (BALF) were determined. H&E staining for lung inflammation was performed.
Viola tricolor treatment at 200 mg/kg significantly decreased IL-4 level but did not considerably affect the IFN-γ level. Therefore, it effectively reduced asthma characteristics including infiltration of leukocytes particularly eosinophil and peribronchial inflammation as compared to dexamethasone. However, Viola tricolor at 100 mg/kg had the most prominent inhibitory effect on the IL-4 level and also markedly increased IFN-γ level. As result, it prevented further reduction of inflammatory parameters in this group compared to the Viola tricolor-treated group at 200 mg/kg. Our study demonstrated that Viola tricolor has anti-inflammatory effects via inhibition of T-helper type 2 (Th2) cytokine production and validated its empirical usage in traditional medicine.
Evaluation of IL-17 Producing Memory Regulatory and Effector T Cells Expressing CD26 Molecule in Patients with Psoriasis
Authors: Esmaeili Behnaz , Mansouri Parvin , Meysamie Alipasha , Izad Maryam 
Published: January 2019

Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation. Human T helper-17 cells (Th-17) express high level of surface CD26, while regulatory T cells are CD26 negative or low and this phenotype is stable even after activation of Treg cells. In this study, we aimed to analyze IL-17 producing Treg cells using CD26.
Memory T cells were isolated from 10 patients with psoriasis and 10 controls. Ex vivo stimulated IL-17 producing regulatory (Forkhead Box P3 (Foxp3)+CD25+CD26-/low) and effector (Foxp3+CD25+CD26hi) memory T cells were analyzed by flow cytometry. IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels were also evaluated.
No significant difference in IL-17+memory regulatory T cells was seen between patients and controls (p=0.19). A significant decrease in the percentage of IL-17 producing CD26hi effector memory T cells was observed in patients (p=0.04). However, the percentage of these cells was not different between patients with mild or severe form of psoriasis compared to controls (p=0.13). We could not find any significant difference regarding IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels in plasma and cell culture supernatant samples between patients and controls.
Taken together, our results showed a reduced IL-17 producing effector memory CD26hi T cells in patients with psoriasis compared to controls. However, IL-17 producing memory regulatory CD4+T cells of patients showed no significant difference from that of controls
Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice
Authors: Izadi Elahe , Vafashoar Fatemeh , Jorbozedar Paria , Assarehzadegan Mohamad Ali , Poormoghim Hadi , Kuhpayezadeh Jalil , Mojtabavi Nazanin 
Published: January 2019

Gender medicine is a new era of science which focuses on the impact of sex hormones and gender on normal physiology, pathobiology and clinical features of diseases. In this study we investigated the impact of pregnancy doses of progesterone hormone on the expression of a couple of matrix metalloproteinase (MMPs), which are known to be involved in tissue remodeling of lungs in health and disease, namely MMP7 and 13.
Pregnancy maintenance dose of progesterone was administered to female BALB/c mice for 21 and 28 days, the control group received PBS for the same days. After removal of the lungs and RNA extraction, quantitative real-time PCR was done using specific primers for MMP7 and MMP13.
We found that progesterone can slightly (not significantly) decrease the expression of MMP13 but had no effect on MMP7.
Our results shows that progesterone has minimal effect on the expression of matrix metalloproteinase7 and matrix metalloproteinase 13, but it may still have an effect on corresponding tissue inhibitor of matrix metalloproteinases (TIMPs) or other components of the Extracellular matrix which remains to be elucidated. Also, the effect of progesterone on these MMPs can be further studied in a fibrosis model.