bluuebunny/crossref_metadata_2025_split huggingface dataset:
T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection
Authors: Qian Zuanhao , Zhang Zhenglei , Wang Yingying 
Published: June 2019

Background
Respiratory syncytial virus (RSV) is the main cause of respiratory tract infection, which seriously threatens the health and life of children. This study is conducted to reveal the rehabilitation mechanisms of RSV infection.

Methods
E-MTAB-5195 dataset was downloaded from EBI ArrayExpress database, including 39 acute phase samples in the acute phase of infection and 21 samples in the recovery period. Using the limma package, differentially expressed RNAs (DE-RNAs) were analyzed. The significant modules were identified using WGCNA package, and the mRNAs in them were conducted with enrichment analysis using DAVID tool. Afterwards, co-expression network for the RNAs involved in the significant modules was built by Cytoscape software. Additionally, RSV-correlated pathways were searched from Comparative Toxicogenomics Database, and then the pathway network was constructed.

Results
There were 2,489 DE-RNAs between the two groups, including 2,386 DE-mRNAs and 103 DE-lncRNAs. The RNAs in the black, salmon, blue, tan and turquoise modules correlated with stage were taken as RNA set1. Meanwhile, the RNAs in brown, blue, magenta and pink modules related to disease severity were defined as RNA set2. In the pathway networks, CD40LG and RASGRP1 co-expressed with LINC00891/LINC00526/LINC01215 were involved in the T cell receptor signaling pathway, and IL1B, IL1R2, IL18, and IL18R1 co-expressed with BAIAP2-AS1/CRNDE/LINC01503/SMIM25 were implicated in cytokine-cytokine receptor interaction.

Conclusion
LINC00891/LINC00526/LINC01215 co-expressed with CD40LG and RASGRP1 might affect the rehabilitation process of RSV infection through the T cell receptor signaling pathway. Besides, BAIAP2-AS1/CRNDE/LINC01503/SMIM25 co-expressed with IL1 and IL18 families might function in the clearance process after RSV infection via cytokine-cytokine receptor interaction.
The Impact of Ethical Climate on Creative Problem -Solving Capacity: An Empirical Study on Human Resource Employees in Saudi Arabia
Authors: Almeshal Soad Abdullah , Aloud Ghada Nasser 
Published: June 2019

Purpose: The purpose of this paper is to determine the impact of ethical climate on creative problem-solving capacity. The paper also aims to identify how knowledge sharing and affective commitment influence this relationship.
Design/Methodology/Approach: This is quantitative descriptive study applied on human resource employees working in companies belong to four different sectors in Saudi Arabia.115 responses were used to test research model using Partial Least Square approach.
Findings: The results reveal that ethical climate indirectly affect creative problem-solving capacity through knowledge sharing. In addition, affective commitment moderates the relationship between knowledge sharing and creative problem-solving capacity.
Research Limitations/Implications: The study conducted only in Saudi Arabia so results cannot be generalized. The study demonstrates the role of ethical climate, knowledge sharing, and affective commitment on enhancing creative problem-solving capacity.

Originality/Value: The paper broaden knowledge on antecedents of creative problem-solving capacity. In addition, the paper extends the line of research on affective commitment by examining its moderating role on the relationship between knowledge sharing and creative problem-solving capacity.
COMPUTATION OF COMBINED REFRACTION - DIFFRACTION
Authors: Berkhoff J.C.W. 
Published: June 2019

This paper treats the derivation of a two-dimensional differential equation, which describes the
phenomenon of combined refraction - diffraction for simple harmonic waves, and a method of solving this
equation. The equation is derived with the aid of a small parameter development, and the method of
solution is based on the finite element technique, together with a source distribution method.
COASTAL ENGINEERING 2000
Authors: Edge Billy L. 
Published: June 2019

*** Available Only Through ASCE ***

http://ascelibrary.aip.org/browse/asce/vol_title.jsp?scode=C

This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone.This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone.This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone.

***********
This volume was originally published by ASCE.
ASCE database link, for record and hard copy purchase:
http://cedb.asce.org/cgi/WWWdisplay.cgi?126156
COASTAL ENGINEERING 2002
Authors: Smith Jane McKee 
Published: June 2019

*** Available Only Through World Scientific ***
http://www.worldscibooks.com/engineering/5165.html

This book contains more than 300 papers presented at the 28th International Conference on Coastal Engineering, held in Cardiff, Wales, in July 2002. It is divided into five parts: coastal waves; nearshore currents, swash, and long waves; coastal structures; sediment transport; and coastal morphology, beach nourishment, and coastal management. The papers cover a broad range of topics, including theory, numerical and physical modeling, field measurements, case studies, design, and management. Coastal Engineering 2002 provides engineers, scientists, and planners with state-of-the-art information on coastal engineering and coastal processes.
COASTAL ENGINEERING 2004
Authors: Smith Jane McKee 
Published: June 2019

*** Available Only Through World Scientific ***
http://www.worldscibooks.com/engineering/5808.html

This comprehensive and up-to-date volume contains 367 papers presented at the 29th International Conference on Coastal Engineering, held in Lisbon, Portugal, 19–24 September 2004. It is divided into five parts: waves; long waves, nearshore currents, and swash; sediment transport and morphology; coastal management, beach nourishment, and dredging; coastal structures. The contributions cover a broad range of topics including theory, numerical and physical modeling, field measurements, case studies, design, and management. Coastal Engineering 2004 provides engineers, scientists, and planners state-of-the-art information on coastal engineering and coastal processes
Development and analysis of long stroke tuned mass damper for earthquakes
Authors: Ishikawa Yoshiyuki , Maseki Ryota , Aono Sho , Kimura Yuichi , Yamato Nobuyuki 
Published: June 2019

AbstractThis paper presents an analytical study of a multistage pendulum tuned mass damper (TMD) with a long stroke. Installing TMD is a practical way of adding damping to existing high‐rise buildings against the possible long‐period and long‐duration earthquakes, because both the TMD and amount of reinforcement to the building have low weights. To verify the effectiveness of the TMD, it is necessary to evaluate the effect of the small rotational and uplifting motions when the weight vibrates with a large amplitude. To evaluate these effects, an analytical model that includes the geometric nonlinearity and uplifting motion of the multistage pendulum TMD is presented. The model is verified by a comparison of the simulation results with experimental results of a shaking table test for a multistage pendulum. The time history analysis of the multistage pendulum, modeled as an 18 degrees of freedom system installed on top of a high‐rise building, is conducted. The rolling, torsional, and uplifting motions did not significantly affect the stable transverse motion of the TMD.
Investigation of Low‐Current Direct Stimulation for Rehabilitation Treatment Related to Muscle Function Loss Using Self‐Powered TENG System
Authors: Wang Jiahui , Wang Hao , He Tianyiyi , He Borong , Thakor Nitish V. , Lee Chengkuo 
Published: June 2019

AbstractMuscle function loss is characterized as abnormal or completely lost muscle capabilities, and it can result from neurological disorders or nerve injuries. The currently available clinical treatment is to electrically stimulate the diseased muscles. Here, a self‐powered system of a stacked‐layer triboelectric nanogenerator (TENG) and a multiple‐channel epimysial electrode to directly stimulate muscles is demonstrated. Then, the two challenges regarding direct TENG muscle stimulation are further investigated. For the first challenge of improving low‐current TENG stimulation efficiency, it is found that the optimum stimulation efficiency can be achieved by conducting a systematic mapping with a multiple‐channel epimysial electrode. The second challenge is TENG stimulation stability. It is found that the force output generated by TENGs is more stable than using the conventional square wave stimulation and enveloped high frequency stimulation. With modelling and in vivo measurements, it is confirmed that the two factors that account for the stable stimulation using TENGs are the long pulse duration and low current amplitude. The current waveform of TENGs can effectively avoid synchronous motoneuron recruitment at the two stimulation electrodes to reduce force fluctuation. Here, after investigating these two challenges, it is believed that TENG direct muscle stimulation could be used for rehabilitative and therapeutic purpose of muscle function loss treatment.
The Puzzle of the Walnut Shell: A Novel Cell Type with Interlocked Packing
Authors: Antreich Sebastian J. , Xiao Nannan , Huss Jessica C. , Horbelt Nils , Eder Michaela , Weinkamer Richard , Gierlinger Notburga 
Published: June 2019

AbstractThe outer protective shells of nuts can have remarkable toughness and strength, which are typically achieved by a layered arrangement of sclerenchyma cells and fibers with a polygonal form. Here, the tissue structure of walnut shells is analyzed in depth, revealing that the shells consist of a single, never reported cell type: the polylobate sclereid cells. These irregularly lobed cells with concave and convex parts are on average interlocked with 14 neighboring cells. The result is an intricate arrangement that cannot be disassembled when conceived as a 3D puzzle. Mechanical testing reveals a significantly higher ultimate tensile strength of the interlocked walnut cell tissue compared to the sclerenchyma tissue of a pine seed coat lacking the lobed cell structure. The higher strength value of the walnut shell is explained by the observation that the crack cannot simply detach intact cells but has to cut through the lobes due to the interlocking. Understanding the identified nutshell structure and its development will inspire biomimetic material design and packaging concepts. Furthermore, these unique unit cells might be of special interest for utilizing nutshells in terms of food waste valorization, considering that walnuts are the most widespread tree nuts in the world.
Intermediates Adsorption Engineering of CO2 Electroreduction Reaction in Highly Selective Heterostructure Cu‐Based Electrocatalysts for CO Production
Authors: Yang Hao , Hu Yu‐wen , Chen Jun‐jie , Balogun M.‐Sadeeq (Jie Tang) , Fang Ping‐ping , Zhang Shanqing , Chen Jian , Tong Yexiang 
Published: June 2019

AbstractThe challenge in the artificial CO2 reduction to fuel is achieving high selective electrocatalysts. Here, a highly selective Cu2O/CuO heterostructure electrocatalyst is developed for CO2 electroreduction. The Cu2O/CuO nanowires modified by Ni nanoparticles exhibit superior catalytic performance with high faradic efficiency (95% for CO). Theoretical and experimental analyses show that the hybridization of Cu2O/CuO nanowires and Ni nanoparticles can not only adjust the d‐band center of electrocatalysts to enhance the intrinsic catalytic activity but also improve the adsorption of COOH* intermediates and suppress the hydrogen evolution reaction to promote the CO conversion efficiency during CO2 reduction reaction. An in situ Raman spectroscopic study further confirms the existence of COOH* species and the engineering intermediates adsorption. This work offers new insights for facile designing of nonprecious transition metal compound heterostructure for CO2 reduction reaction through adjusting the reaction pathway.
Association of physical inactivity with blood pressure and cardiovascular risk factors in Amerindian schoolchildren
Authors: Alvarez Cristian , Ramírez‐Campillo Rodrigo , Sáez‐Lafourcade Roberto , Delgado‐Floody Pedro , Martínez‐Salazar Cristian , Celis‐Morales Carlos , Ramírez‐Vélez Robinson , Alonso‐Martínez Alicia , Izquierdo Mikel 
Published: June 2019

AbstractObjectivesThere is a wealth of published data on blood pressure (BP) and physical activity in adults of European descent, but less information is available for Amerindian schoolchildren. The aim of this study was to investigate whether BP and other cardiometabolic risk factors differ by physical activity levels in schoolchildren from different ethnic backgrounds.MethodsThis was a cross‐sectional study of 540 schoolchildren (6‐13 years) from two ethnic backgrounds (n = 119 Mapuche Amerindians and n = 421 of European descent). Physical activity was measured using international physical activity recommendations and a standard questionnaire, and ethnicity was classified according to previous methods using surnames. The population was divided into the following four groups: (a) physically active Mapuches (n = 45) and of European descent (n = 101); and (b) physically inactive Mapuches (n = 74) and of European descent (n = 320).ResultsIn physically inactive schoolchildren, significant differences were found between schoolchildren of Mapuche and European descent in systolic (134 ± 3 mmHg vs 130 ± 5 mmHg, respectively, P = .034) and diastolic BP (85 ± 13 mmHg vs 81 ± 3 mmHg, P = .029). For other cardiometabolic risk factors, schoolchildren with Mapuche surnames were significantly less likely to be classified with normal weight (5 [6.8%] vs 85 [26.6%]), and more likely to be obese (30 [40.5%] vs 76 [26.6%]) at P < .0001 than European peers. Additionally, significant differences were found between Mapuche schoolchildren vs European peers in the outcomes body mass (51.2 ± 18 kg vs 47.0 ± 15), z score of body mass index (2.16 vs 1.70), fat‐to‐muscle mass ratio (1.68 vs 0.96), resting heart rate (81.7 ± 10 vs 86.8 ± 16), waist circumference (89.3 ± 5 cm vs 76.3 ± 2 cm), muscle mass (18.2 ± 3 kg vs 16.2 ± 2 kg), and handgrip strength normalized by body mass (0.68 vs 0.57 kg).ConclusionUnder conditions of similar physical inactivity, Mapuche schoolchildren have a more adverse cardiovascular and adiposity profile than their counterparts of European descent.
Erroneous inference based on a lack of preference within one group: Autism, mice, and the social approach task
Authors: Nygaard Kayla R. , Maloney Susan E. , Dougherty Joseph D. 
Published: June 2019

AbstractThe Social Approach Task is commonly used to identify sociability deficits when modeling liability factors for autism spectrum disorder (ASD) in mice. It was developed to expand upon existing assays to examine distinct aspects of social behavior in rodents and has become a standard component of mouse ASD‐relevant phenotyping pipelines. However, there is variability in the statistical analysis and interpretation of results from this task. A common analytical approach is to conduct within‐group comparisons only, and then interpret a difference in significance levels as if it were a group difference, without any direct comparison. As an efficient shorthand, we named this approach EWOCs: Erroneous Within‐group Only Comparisons. Here, we examined the prevalence of EWOCs and used simulations to test whether this approach could produce misleading inferences. Our review of Social Approach studies of high‐confidence ASD genes revealed 45% of papers sampled used only this analytical approach. Through simulations, we then demonstrate how a lack of significant difference within one group often does not correspond to a significant difference between groups, and show this erroneous interpretation increases the rate of false positives up to 25%. Finally, we define a simple solution: use an index, like a social preference score, with direct statistical comparisons between groups to identify significant differences. We also provide power calculations to guide sample size in future studies. Overall, elimination of EWOCs and adoption of direct comparisons should result in more accurate, reliable, and reproducible data interpretations from the Social Approach Task across ASD liability models. Autism Res 2019, 12: 1171–1183. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThe Social Approach Task is widely used to assess social behavior in mice and is frequently used in studies modeling autism. However, reviewing published studies showed nearly half do not use correct comparisons to interpret these data. Using simulated and original data, we argue the correct statistical approach is a direct comparison of scores between groups. This simple solution should reduce false positives and improve consistency of results across studies.
Ultrastructural, cytogenetic, and molecular findings in mast cell leukemia: Case report
Authors: Bosch‐Vilaseca Anna , Monter‐Rovira Anna , Cisa‐Wieczorek Sabina , Oñate Guadalupe , Bussaglia Elena , Carricondo Maite , Remacha Ángel , Martínez Clara , Pratcorona Marta , Blanco María Laura , Nomdedéu Josep F. 
Published: June 2019

AbstractWe report a de novo aleukemic form of MCL with a complex monosomic karyotype with LOH for multiple chromosomes and TP53 mutation. Additionally, whereas D816V KIT was not found, the c‐Kit transmembrane domain p.M541L variant was detected which is the most common SNP of KIT gene in humans with controversial pathogenic role. In these cases, it is crucial to perform a rapid broad molecular study for an accurate diagnosis which could help to initiate targeted therapy.
Mono‐Active Bimetallic Oxide Co2AlO4 with Yolk‐Shell Structure as a Superior Lithium‐Storage Material
Authors: Zeng Kewen , Tan Lei , Li Xinhai , Wang Zhixing , Guo Huajun , Wang Jiexi , Yan Guochun 
Published: June 2019

AbstractThe mono‐active bimetallic oxide Co2AlO4 with microsphere morphology and yolk‐shell structure are synthesized and first evaluated as anode materials for lithium ion batteries. The electrochemically inactive Al element disperse well in the material at an atomic‐scale level, which can effectively alleviate volume expansion during the cycling and heighten the electrochemical reaction kinetics. Moreover, the yolk‐shell structure provides adequate buffer space for volume expansion. Benefited from the synergy effect of the yolk‐shell structure and uniformly element Al distribution, the yolk‐shell Co2AlO4 delivers a discharge capacity of 661 mAh g−1 at 1000 mA g−1 after 500 cycles with a capacity retention ratio of 86.4 %, and maintains a high discharge capacity of 548 mAh g−1 at 3200 mA g−1, showing excellent long‐term cycle performance and rate capability.
The Role of Supported Atomically Distributed Metal Species in Electrochemistry and How to Create Them
Authors: Ding Yuxiao , Schlögl Robert , Heumann Saskia 
Published: June 2019

AbstractSupported atomically distributed metal species are extensively applied as catalysts to exceed the properties of their bulk analogues. Their electronic structures can be easily tuned by neighboring support atoms or ligands to control their activities for different reactions. The high accessibility and therefore almost 100 % reactivity of the highly distributed active sites provide new opportunities for electrochemical applications that were previously only suitable for noble metals. Although a lot of work has been done in this area, the demand for large‐scale applications and, therefore, also large‐scale production is still far from sufficient. In this Review, we selected some recent publications to show the current state of applications of dispersed single‐atom catalysts in the oxygen reduction/evolution reaction and hydrogen evolution reaction, with a focus on their mechanisms in reactions, the underlying challenges, and synthesis methods. A further discussion on how the electrocatalytic performance of the supported single atom catalysts can be tailored to meet the requirements of large‐scale applications is also proposed.
Controlling Stability and Selectivity in the Competing Chlorine and Oxygen Evolution Reaction over Transition Metal Oxide Electrodes
Authors: Exner Kai S. 
Published: June 2019

AbstractChlor‐alkali electrolysis is a large‐scale industrial process, where the evolution of gaseous chlorine (chlorine evolution reaction, CER) at the anode is accompanied by a selectivity problem as the evolution of gaseous oxygen (oxygen evolution reaction, OER) constitutes an undesirable side reaction, which diminishes chlorine selectivity. The active component in the anode material is RuO2with the (110) facet as most stable surface termination, for which the elementary reaction steps on an atomic scale of the competing CER and OER are already resolved. Here, the selectivity issue and the stability range of a RuO2(110) electrode are explored under CER/OER conditions by combining the kinetic description with surface Pourbaix diagrams and linear scaling relationships. These investigations directly merge into a advanced material screening approach, indicating that the free energy difference between the limiting OOH (OER) and OCl (CER) adsorbate is reconciled as a measure for stability and CER selectivity. This finding supports computational researchers within their search of improved electrode materials based on transition metal oxides for electrocatalytic chlorine formation.