bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐scale modelling of the tensile behavior of lithium ion battery cellulose separator
Authors: Xie Weigui , Liu Wangyu , Dang Yanping , Peng Yujian 
Published: April 2019

AbstractAs a satisfactory green material for a lithium ion battery separator, cellulose possesses better wettability and superior thermal and chemical stability compared to commercial polyolefin separators. The macroscopic mechanical properties of the separator are determined by structural parameters on different dimensional scales. In this paper, a two‐scale modelling method is proposed for a cellulose separator. At micro‐scale, a single fiber structural model was established with a cross‐sectional profile extracted through image processing, combined with the fiber helix angle. At meso‐scale, a representative volumetric element model and a two‐dimensional random fibrous model for the fibrous network of the cellulose separator were developed. The elastic modulus in the machining direction (MD) and transverse direction (TD) of the two models were calculated by finite element simulation and compared with experimental data. The results show that the elastic modulus of the models is slightly larger than that from experiments. Compared to experiments, the relative errors in the MD and TD of the representative volumetric element model are 2.80% and 6.78%, respectively. The relative errors in the MD and TD of the two‐dimensional random fibrous model are 6.70% and 8.47%, respectively. Consequently, multi‐scale modelling is proven to have considerable value in investigating the properties of fibrous materials. © 2019 Society of Chemical Industry
Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non‐Small Cell Lung Cancer
Authors: An Taixue , Qin Sihua , Sun Dehua , Huang Yiyao , Hu Yanwei , Li Shaopeng , Zhang Han , Li Bo , Situ Bo , Lie Linmiao , Wu Yingsong , Zheng Lei 
Published: April 2019

AbstractExtracellular vesicles (EVs) mediate intercellular communication via transferring proteins and other biological molecules and have been recently investigated as biomarkers of disease. Sensitive and specific biomarkers are required for lung cancer diagnosis and prognosis. The present study screens for abnormal EV proteins in non‐small cell lung cancer (NSCLC) using a quantitative proteomics strategy involving LC‐MS/MS to identify ideal biomarkers for NSCLC diagnosis. EVs are enriched from the sera of early and advanced NSCLC patients and healthy controls and from cell culture supernatants of lung adenocarcinoma and bronchial epithelial cell lines. In the sera and supernatants, 279 and 632 differentially expressed proteins, respectively, are associated with signaling pathways including extracellular membrane–receptor interaction, focal adhesion, and regulation of the actin cytoskeleton. Thirty‐two EV proteins are identified at the intersection of differentially expressed proteins between the NSCLC groups and cell lines. Based on bioinformatics analysis, in silico immunohistochemical, and PRM verification, fibronectin is selected for following in vitro studies and validation with an independent cohort. Fibronectin on EVs is estimated to perform well in the diagnosis of NSCLC patients based on AUC, showing great potential for clinical use and demonstrating the efficacy of this method for EV‐associated biomarker screening.
iTRAQ‐Based Quantitative Proteomic Analysis Strengthens Transcriptomic Subtyping of Triple‐Negative Breast Cancer Tumors
Authors: Jézéquel Pascal , Guette Catherine , Lasla Hamza , Gouraud Wilfried , Boissard Alice , Guérin‐Charbonnel Catherine , Campone Mario 
Published: April 2019

AbstractHeterogeneity and lack of targeted therapies represent the two main impediments to precision treatment of triple‐negative breast cancer (TNBC). Therefore, molecular subtyping and identification of therapeutic pathways are required to optimize medical care. The aim of the present study is to define robust TNBC subtypes with clinical relevance by means of proteomics and transcriptomics. As a first step, unsupervised analyses are conducted in parallel on proteomics and transcriptomics data of 83 TNBC tumors. Proteomics data unsupervised analysis did not permit separation of TNBC into different subtypes, whereas transcriptomics data are able to clearly and robustly identify three subtypes: molecular apocrine (C1), basal‐like immune‐suppressed (C2), and basal‐like immune response (C3). Supervised analysis of proteomics data are then conducted based on transcriptomics subtyping. Thirty out of 62 proteins differentially expressed between C1, C2, and C3 belonged to biological categories which characterized these TNBC clusters: luminal and androgen‐regulated proteins (C1), basal, invasion, and extracellular matrix (C2), and basal and immune response (interferon pathway and immunoglobulins) (C3). Although proteomics unsupervised analysis of TNBC tumors is unsuccessful at identifying clusters, the integrated approach is promising. Identification and measurement of 30 proteins strengthen subtyping of TNBC based on robust transcriptomics unsupervised analysis.
iTRAQ‐Based Quantitative Proteomic Analysis of Duck Eggshell During Biomineralization
Authors: Zhu Feng , Zhang Fan , Hincke Maxwell , Yin Zhong‐Tao , Chen Si‐Rui , Yang Ning , Hou Zhuo‐Cheng 
Published: April 2019

AbstractThe avian egg is a valuable model for the calcitic biomineralization process as it is the fastest calcification process occurring in nature and is a clear example of biomineralization. In this study, iTRAQ MS/MS is used to detect and study for the first time: 1) the overall duck eggshell proteome; 2) regional differences in the proteome between the inner and outer portions of the duck eggshell. The new reference protein datasets allow us to identify 179 more eggshell proteins than solely using the current release of Ensembl duck annotations. In total, 484 proteins are identified in the entire duck eggshell proteome. Twenty‐eight novel proteins of unknown function that are involved in eggshell formation are also identified. Among the identified eggshell proteins, 54 proteins show differential abundances between the inner, partially mineralized eggshell (obtained 16 h after ovulation) compared to the overall complete eggshell (normally expulsed eggshell). At least 64 of the abundant matrix proteins are common to eggshell of 4 different domesticated bird species (chicken, duck, quail, turkey) and zebra finch. This study provides a new resource for avian eggshell proteomics, and augments the inventory of eggshell matrix proteins that will lead to a deeper understanding of calcitic biomineralization.
Challenges and Opportunities in Cancer Metabolomics
Authors: Kumar Ashish , Misra Biswapriya B. 
Published: April 2019

AbstractChallenges in metabolomics for a given spectrum of disease are more or less comparable, ranging from the accurate measurement of metabolite abundance, compound annotation, identification of unknown constituents, and interpretation of untargeted and analysis of high throughput targeted metabolomics data leading to the identification of biomarkers. However, metabolomics approaches in cancer studies specifically suffer from several additional challenges and require robust ways to sample the cells and tissues in order to tackle the constantly evolving cancer landscape. These constraints include, but are not limited to, discriminating the signals from given cell types and those that are cancer specific, discerning signals that are systemic and confounded, cell culture‐based challenges associated with cell line identities and media standardizations, the need to look beyond Warburg effects, citrate cycle, lactate metabolism, and identifying and developing technologies to precisely and effectively sample and profile the heterogeneous tumor environment. This review article discusses some of the current and pertinent hurdles in cancer metabolomics studies. In addition, it addresses some of the most recent and exciting developments in metabolomics that may address some of these issues. The aim of this article is to update the oncometabolomics research community about the challenges and potential solutions to these issues.
A Paper‐Based Platform for Long‐Term Deposition of Nanoparticles with Exceptional Redispersibility, Stability, and Functionality
Authors: Cho Hui Hun , Kim Su Ji , Jafry Ali Turab , Lee Byoungsang , Heo Jun Hyuk , Yoon Seokyoung , Jeong Sun Hwan , Kang Seong‐Il , Lee Jung Heon , Lee Jinkee 
Published: April 2019

AbstractAlthough nanoparticles (NPs) can be carefully engineered to have maximal stability and functionality desirable for use in diverse applications, they are generally not suitable for long‐term storage in solution. It is also difficult to store NPs in a dry state because dried NPs generally become aggregated and cannot easily be redispersed. Thus, a new strategy allowing long‐term storage of NPs with high stability, redispersibility, and functionality is highly demanded. By passivating the 13 nm gold nanoparticle (AuNP) surface with stabilizing agents and treating a paper substrate with both bovine serum albumin and sucrose after coating with a hydrophobic polyvinyl butyral layer, it is possible to fully redisperse (≈100%) dried AuNPs with colloidal stability comparable to that of as‐prepared AuNPs. Furthermore, AuNPs physically stabilized with polyvinylpyrrolidone can react with thiol‐containing compounds, such as 1,4‐dithiothreitol (DTT). Taking advantage of the oxidation reaction of hypochlorous acid with DTT, it is possible to demonstrate a paper‐based colorimetric sensor for detection of residual chlorine in water. Since this strategy is applicable to large‐sized AuNPs (30–90 nm), silver NPs, oleic acid‐capped magnetic NPs, and cetrimonium bromide‐passivated gold nanorods, it can be used for diverse NPs requiring long‐term storage for many applications.
Magnetic Carbon Composite Particles for Dye Adsorption from Water and their Electrochemical Regeneration
Authors: Schneider Michael , Ballweg Thomas , Groß Lennart , Gellermann Carsten , Sanchez‐Sanchez Angela , Fierro Vanessa , Celzard Alain , Mandel Karl 
Published: April 2019

AbstractHerein, the development of a novel composite particle system prepared from superparamagnetic Fe3O4@SiO2 microparticles as core and coated with a carbon shell is presented. The coating with carbon is done by pyrolyzing furan resin, which was previously deposited on the particle surface by poly‐merization of furfuryl alcohol. The novel composite material thus combines magnetic and sorptive properties. Upon pyrolysis the magnetic material is converted from magnetite to α‐iron and fayalite, changing its behavior from superparamagnetic to ferromagnetic with nearly zero remanence. The magnetic properties can be utilized to magnetically collect the particles dispersed in fluids, whereas the sorptive properties of the carbon shell can be used to remove organic contaminants from these fluids. The adsorption behavior of the composite particles and a potential electrochemical regeneration route are investigated, using the model dye methylene blue.
Cool storage of Queensland fruit fly pupae for improved management of mass production schedules
Authors: Benelli Maurizio , Ponton Fleur , Lallu Urvashi , Mitchell Katherine A , Taylor Phillip W 
Published: April 2019

AbstractBACKGROUNDCool storage is a valuable means of manipulating insect development time. The Queensland fruit fly (Q‐fly) is Australia's most economically significant pest of fruit crops. The present study investigates cool storage of Q‐fly pupae for increasing production flexibility for sterile insect technique programs. Development time, survival and fly quality were assessed following continuous storage of 1‐day‐old pupae at temperatures ranging from 13 to 25 °C.RESULTSSurvival was reduced almost to zero by pupal storage at 13 and 15 °C, was greatly reduced by storage at 17 °C, and was modestly reduced by storage at 19 °C. Pupal development time was extended by 16 days at 17 °C and by 9 days at 19 °C. Cool storage negatively affected flight ability and depleted lipid reserves. Cool storage at 19 °C enhanced the ability of 3‐day‐old adults to recover from chill‐coma compared to control flies, indicating cold acclimation.CONCLUSIONThere is potential for use of cool storage in Q‐fly mass rearing, especially to improve alignment between production and field releases. For the purpose of delaying the development time of Q‐fly pupae with minimal quality reduction, storage at 23 °C is recommended for 1‐day‐old pupae. © 2019 Society of Chemical Industry
Efficacy of reduced rates of chlorantraniliprole seed treatment on insect pests of irrigated drill‐seeded rice
Authors: Villegas James M , Wilson Blake E , Stout Michael J 
Published: April 2019

AbstractBackgroundFor the past decade, insecticidal seed treatment has been the most widely used control tactic against insect pests of rice (Oryza sativa L.) in the USA. Seed treatments are used primarily to control the most economically important early‐season pest of rice, the rice water weevil (Lissorhoptrus oryzophilus Kuschel). This study was conducted to evaluate the efficacy of reduced rates of chlorantraniliprole seed treatment against the rice water weevil, fall armyworm (Spodoptera frugiperda J.E. Smith), and sugarcane borer (Diatraea saccharalis F.) under field and laboratory conditions. Concentrations of chlorantraniliprole in plant tissues were determined at vegetative and reproductive developmental stages of rice plants.ResultsChlorantraniliprole seed treatment reduced the densities of rice water weevil larvae relative to non‐treated controls even at rates 75% lower than the label rate. Increased mortality of fall armyworm larvae was observed at reduced seed treatment rates relative to a non‐treated control. Chlorantraniliprole seed treatment increased the mortality of sugarcane borer larvae at all rates relative to controls and the mortality was consistently higher in larvae that were fed stems from treated plants at the vegetative developmental stage than larvae that were fed stems from plants at the reproductive stage. Concentrations of chlorantraniliprole in plant tissues increased with seed treatment rate and decreased with plant age.ConclusionThis study has shown that reduced chlorantraniliprole seed treatment rates can provide adequate control against the rice water weevil, fall armyworm, and sugarcane borer, particularly at early developmental stages of rice plants. © 2019 Society of Chemical Industry
The Marche: Italy's new frontier for international retirement migration
Authors: King Russell , Cela Eralba , Morettini Gabriele , Fokkema Tineke 
Published: April 2019

AbstractWithin the linked fields of population, migration, and ageing, international retirement migration (IRM) has emerged as a strong focus for empirical research. Thus far, the classic studies have been on European North–South IRM, with a specific concentration on iconic regions such as the Costa del Sol, southern France, and Tuscany. But the geography of IRM is constantly changing, as prior destination regions become “saturated” and perhaps too expensive, so that new “frontiers” are opened up. One such frontier is the Italian region of Marche, now seen as a cheaper and more “authentic” region than Tuscany. This paper uses interview narratives from 69 older age British, Dutch, and German people who have relocated, as either permanent settlers or seasonal residents, in the Marche, in order to answer two questions. The questions relate first to the main drivers of IRM at the decision‐making level and, second, to the experiences of living there, including advantages and disadvantages. We find the participants for the most part engaged in active ageing, growing their own produce, and joining in local community life and are appreciative of the beauty of the hilly landscape. However, “full” integration is hampered by language and cultural barriers, whereas the bureaucracy is their main complaint.
The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
Authors: Karimian Jahangir , Hadi Amir , Pourmasoumi Makan , Najafgholizadeh Ameneh , Ghavami Abed 
Published: April 2019

Background and ObjectivesThe impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM).MethodsA comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random‐effects model was applied in the meta‐analysis to compensate for potential heterogeneity among the included studies.ResultsSix randomized controlled trials comprising 373 participants were included in the systematic review and meta‐analysis. The results of the meta‐analysis revealed significant reductions in fasting plasma glucose (−13.51 mg/dl; 95% CI [−24.98, −2.04]) and hemoglobin A1C (−0.52%; 95% CI [−0.94, −0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (−0.53 pmol/L; 95% CI [−1.69, 0.63]) or homeostasis model assessment of insulin resistance (−0.543; 95% CI [−1.72, 0.64]).ConclusionThis systematic review and meta‐analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.
Extended representation of wind–mass correlation by ensemble forecasting for data assimilation
Authors: Song Hyo‐Jong 
Published: April 2019

AbstractInitialization for numerical weather prediction models is of utmost importance especially in the short‐range forecast of the weather accompanying extreme events such as heavy rainfall, heatwaves, and so on. The balance relationship between wind and mass in the initialized field has been an important issue since Richardson's first attempt at numerical prediction. In a climatological framework, regressed‐linear and analytic‐nonlinear balancing methods are used to impose the wind–mass correlation onto the analysis increment, which results from data assimilation procedures. The advection of horizontal wind destroys the isotropy assumption by the regressed‐linear balance approach. The nonlinear balance equation approach including the advection process reduces this disadvantage more or less. However, it is shown that forecast ensemble correlation helps even the regressed balance approach to address the anisotropy in the hybridization framework. The regressed balance approach, in common with the nonlinear balance, experiences (a) considerable residual of the horizontal momentum conservation in the Antarctic stratosphere, and (b) lack of thermodynamic energy relationship between divergent wind and temperature in the Tropics. This study demonstrates with phenomenological examples that these weaknesses of the traditional (especially, regressed) methods are effectively resolved by forecast ensemble covariance.
Validating additive correction schemes against gradient‐based extrapolations
Authors: Kraus Peter , Frank Irmgard 
Published: April 2019

AbstractThe use of additive correction schemes to obtain structures and vibrational frequencies of increasingly larger molecules is becoming more common. Such approaches, based on the cubic extrapolation formula applied directly to the quantity of interest, have been successfully validated only at the highest levels of computational accuracy: for coupled cluster methods with comparably large basis sets. Here, a systematic validation of geometries and vibrational frequencies is carried out, including more affordable and relevant levels of theory, such as the Møller‐Plesset perturbation theory applied with smaller basis sets. Comparisons of such additive schemes against the more rigorous gradient‐based extrapolation are presented. The cbs() routine of the open‐source quantum‐chemistry package Psi4 has been extended for this purpose. The results confirm that geometries and frequencies of covalently bound species obtained with additive correction schemes are in an excellent agreement with the results of gradient‐based extrapolations. However, when applied to systems involving noncovalent interactions, the errors due to such schemes are significantly larger. In general, we propose the application of gradient‐based extrapolations, as they incur no extra cost compared to additive schemes.
A specified‐time control framework for control‐affine systems and rigid bodies: A time‐rescaling approach
Authors: Peng Xiuhui , Sun Junyong , Geng Zhiyong 
Published: April 2019

SummaryThis paper addresses the specified‐time control problem for control‐affine systems and rigid bodies, wherein the specified‐time duration can be designed in advance according to the task requirements. By using the time‐rescaling approach, a novel framework to solve the specified‐time control problem is proposed, and the original systems are converted to the transformation systems based on which the specified‐time control laws for both control‐affine systems and rigid bodies are studied. Compared with the existing approaches, our proposed specified‐time control laws can be derived from the known stabilization control laws. To our best knowledge, it is the first time that transformation system–based specified‐time control framework for control‐affine system and rigid body dynamics is proposed. To further improve the convergence performance of specified‐time control, a finite‐time attitude synchronization control law for rigid bodies on rotation matrices is proposed, and thereby, the finite‐time–based specified‐time control law is designed eventually. In the end, numerical simulations and SimMechanics experiments are provided to illustrate effectiveness of the theoretical results.
Simultaneous fault detection and antisaturated control based on dynamic observer for inverted pendulum control system
Authors: Pang Guochen , Cao Jinde , Chen Xiangyong , Qiu Jianlong 
Published: April 2019

SummaryThis paper focuses on the problem of simultaneous fault detection and antisaturated control for an inverted pendulum control system. The system input is the acting control voltage that generates the force on the cart. However, the acting control voltage is obviously limited by the voltage amplitude. This means that the actuator of the constructed system model is saturated. Hence, the detector/controller unit produces two signals: the detection and antisaturated control. In this process, the effects of disturbances and noises on detection and control purposes need to be suppressed. Finally, two simulation examples verify the effectiveness of the method.
Three‐Dimensional Ordered Structures of Metal‐Organic Frameworks for Carbon Tetrachloride Sensing and Comparative Study
Authors: Luo Wenyang , Zheng Yue , Yan Jun , Chen Yunlin 
Published: April 2019

AbstractThree‐dimensional (3D) ordered structure of PS@ZIF‐8 and FT‐ZIF‐8 was prepared by self‐assembly method. The 3D ordered structure of PS@ZIF‐8 and FT‐ZIF‐8 were used to investigate the sensing characteristics for carbon tetrachloride in real time, and the two structures exhibited good response to carbon tetrachloride. It was found that the response time required to reach the maximum reflection peak only 2 s for FT‐ZIF‐8, and the shift of the reflection peak from about 825 nm to 836 nm of about 31 nm for PS@ZIF‐8. The relationship of the shift peak position with different concentration of carbon tetrachloride was demonstrated to be linear. Moreover, The fabricated 3D ordered structures exhibited high long‐term, repeatability and stability, which are beneficial for practical applications.