bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients report more severe daily limitations than recognized by their physicians
Authors: Castro Renata R. T. , Joyce Emer , Lakdawala Neal K. , Stewart Garrick , Nohria Anju , Givertz Michael M. , Desai Akshay , Lewis Eldrin F. , Stevenson Lynne W. 
Published: October 2019

AbstractBackgroundPatient limitations guide selection of heart failure therapies, for which indications often specify New York Heart Association Class.ObjectivesTo determine the extent of patient‐reported limitations during daily activities and compare to New York Heart Association class assigned by providers during the same visit, and to left ventricular ejection fraction (LVEF) group.Methods and ResultsWhile waiting for their appointment, 948 patients on return visits to an ambulatory HF clinic completed a written questionnaire assessing specific activity limitations, which were compared to physician‐assigned NYHA class during the same visit. Patient‐reported limitation to perform daily activity ranged from 25% for bathing to 61% for yardwork or housework and 71% for jogging or hurrying. Most patients who did not report limitations to perform daily life activities were correctly classified as NYHA I by the physicians (76%), but 12% of the 376 patients classified as NYHA I reported limitations to showering or bathing and 73% reported limitations while doing yardwork or house work. Limitation to walking was reported by 172 patients (50%) classified as class II. Limitations to walking one block were most common in patients with LVEF ≥40% compared to patients with LVEF <40%, and least commonly, in HF with better EF (improved from 31 ± 13 to 52 ± 7).ConclusionsActivity limitations are commonly reported by ambulatory HF patients, but underestimated by physicians. It is not clear how this should guide therapy validated for NYHA class but focused activity questions may merit wider use to track limitations and improvement in ambulatory HF.
Detection of concealed structural heart disease by imaging in patients with apparently idiopathic premature ventricular complexes: A review of current literature
Authors: Sassone Biagio , Muser Daniele , Casella Michela , Luzi Mario , Virzì Santo , Balla Cristina , Nucifora Gaetano ,   for the Task Force on Imaging and Task Force on Ablation of Ventricular Tachycardia of the Italian Association of Arrhythmias and Cardiac Pacing (AIAC)
Published: October 2019

AbstractBackgroundPremature ventricular complexes (PVCs) are the most common form of ventricular arrhythmia in the general population. While in most cases PVCs represent a primitive phenomenon with benign behavior, in a non‐negligible proportion of subjects frequent PVCs may be epiphenomenon of underlying occult heart diseases, requiring special medical attention since they have been resulted linked to increased total and cardiac mortality. Nevertheless, PVCs themselves, when incessantly frequent, may be responsible for left ventricular dysfunction in otherwise normal heart. Aim of this narrative review is to update current knowledge on the general approach to patients with frequent PVCs on the basis of available data, with a special focus on the value of imaging.HypothesisRoutine diagnostic work‐up not infrequently miss subtle concealed arrhythmic substrate, leading to erroneously refer to such arrhythmias as to “idiopathic”.MethodsLiterature search of PVCs articles was conducted in PubMed and Scopus electronic database.ResultsConflicting data arise from literature about the true clinical significance of idiopathic PVCs. There is growing body of data providing evidence that more advanced non‐invasive imaging modalities, such as cardiac magnetic resonance, have an incremental diagnostic and prognostic value. On the other hand, in some cases the prognostic significance of isolated subtle myocardial structural abnormalities in patients with PVCs, still remains area of uncertainty.ConclusionIn selected subjects with PVCs and high‐risk features for concealed arrhythmic substrate, traditional assessment to rule out the presence of heart disease, including surface ECG and transthoracic echocardiography, should be implemented with more advanced cardiovascular imaging modalities.
Lumbar spinal cord neurons putatively involved in ejaculation are sexually dimorphic in early postnatal mice
Authors: Federighi Giuseppe , Asteriti Sabrina , Cangiano Lorenzo 
Published: October 2019

AbstractA crucial role in ejaculation is thought to be played by a population of lumbar spino‐thalamic neurons (LSt), which express galanin and other neuropeptides. In rats, these neurons are activated with ejaculation and their lesion selectively abolishes ejaculation but not other mating behaviors. Consistently with their role, in adult rats and humans, LSt neurons are sexually dimorphic, being more numerous in males. Here we examined whether sexual dimorphism arises early in development, using a transgenic mouse line in which the expression of fluorescent protein is driven by the galanin promoter. We focused on postnatal day 4, shortly after a transient perinatal androgen surge in males that could play an organizational role in LSt development. We found a population of brightly fluorescent neurons organized in bilateral columns dorsolateral to the central canal in segments L1–L5, the expected location of the LSt group. Their number was close to that of adult preparations and significantly greater in male than in female siblings (+19%; CI95%: +13% to +27%; p < .01). This was not due to a generalized higher galanin expression in the male since fluorescent L4 DRG neurons, innervating the hindlimbs and lower back, were not significantly dimorphic (−4%; CI95%: −10% to +8%; p = .92). Unexpectedly, we found in cervical segments a population of fluorescent neurons having a location relative to the central canal similar to the LSt. Thus, the LSt group is sexually dimorphic soon after birth. However, it is possible that only a subset of its neurons participate in the control of ejaculation.
Optimization of a spectrally tunable daylight simulator using four quantum dot light‐emitting diodes for visual appraisal of color
Authors: Feng Qi , Zhao Yifei , Ding Ke , Zhong Ping , He Guoxing 
Published: October 2019

AbstractAn optimization model for luminous efficacy of a spectrally tunable light‐emitting diode (LED) daylight simulator under constraint of metamerism index was developed. It was first reported that the optimal spectrally tunable LED daylight simulator of AA grade for D50, D55, D65, and D75 standard illuminants could consist of two quantum dot‐integrated LEDs (QDLEDs) with the ultraviolet chip and two other QDLEDs with the blue chip. The optimized spectral parameters of each QDLED, as well as photometric and colorimetric performances of D50, D55, D65, and D75 daylight simulators, were obtained by maximizing luminous efficacy under the metamerism index for both a visible and ultraviolet range less than 0.25. The limit luminous efficacies of four daylight simulators using four QDLEDs under the ideal case will reach 181 lm/W to 205 lm/luminous efficacies with a radiant efficiency of both the ultraviolet and blue chips of 60%, as well as a quantum efficiency of a quantum dots layer of 90%, will reach 100 lm/W to 112 lm/W.
Color and culture: Innovations and insights since Basic Color Terms—Their Universality and Evolution (1969)
Authors: Jameson Kimberly A. , Webster Michael A. 
Published: October 2019

AbstractFifty years ago, in 1969, Berlin & Kay published Basic Color Terms—Their Universality and Evolution and set in‐motion a large‐scale systematic research program for studying color naming and categorization across first‐language speakers from different ethno‐linguistic societies. While it is difficult to gauge the impact a research program can make over 50‐years, many linguists, anthropologists, cognitive scientists, and perceptual psychologists consider the Berlin & Kay book as one of the top‐most influential works in cross‐cultural studies not only of color linguistics, but of cognition and language more generally. Today reverberations from the Berlin & Kay (1969) research program continue to resonate through recently available data sets that are being examined with new quantitative analysis methods and modeling approaches. Here we review the origins of the Basic Color Terms phenomenon, and note a few of the numerous directions from which on‐going related work continues to bring forth interesting results in the color categorization arena.
pH‐Dependent Absorption Spectrum of Oxyluciferin Analogues in the Presence of Adenosine Monophosphate
Authors: Manuel de Almeida Barbosa Nuno , Zemmouche Madjid , Gosset Pauline , García‐Iriepa Cristina , Ledentu Vincent , Navizet Isabelle , Didier Pascal , Ferré Nicolas 
Published: October 2019

AbstractThe photophysical properties of oxyluciferin, the light emitter responsible for firefly bioluminescence, are pH‐dependent. One of the potential proton acceptor/donor is adenosine monophosphate (AMP). We have studied three oxyluciferin synthetic analogues with or without AMP, in water, in the pH=5 to 11 range, using both experimental steady‐state absorption spectroscopy or the recently developed computational protocol that uses constant pH molecular dynamics and then hybrid QM/MM calculations (CpHMD‐then‐QM/MM). The latter features a systematic investigation of all the protonation microstates using molecular dynamics simulations coupled to thousands hybrid QM/MM vertical excitation energies. Our results demonstrate that AMP does not significantly modify the visible light absorption of the analogues, whatever the pH value. We also show that CpHMD‐then‐QM/MM is capable to qualitatively reproduce the pH‐dependent absorption spectrum of the analogues, despite the employed low QM level of theory.
A novel conditional anonymity scheme for vehicular communication networks
Authors: Wang Xiaoliang , Bai Liang , Mausler Brandon , Singh Pitam 
Published: October 2019

SummaryVehicular communication networks are traffic applications of the Internet of Things consisting of vehicle nodes, roadside units, service providers, and other components. To protect the vehicle privacy, some vehicular communication networks adopt anonymous schemes. However, in these anonymous schemes, anonymity abuse is inevitable. In order to protect vehicular privacy and prevent anonymity abuse, some conditional anonymous authentication schemes based on cryptography have been proposed. However, most of these methods have complex computation and large communication overhead, which makes them difficult to meet the actual requirement of high‐speed traffic in vehicular communication networks. In this paper, a novel conditional anonymity scheme called VKPCA (vehicular communication network based on kernel principal component analysis [KPCA]) is proposed, which can protect vehicle privacy while avoid anonymity abuse. The simulation results show that this scheme has lower computational complexity and communication overhead than the conventional anonymous authentication scheme.
Frizzled 4 regulates ventral blood vessel remodeling in the zebrafish retina
Authors: Caceres Lucia , Prykhozhij Sergey V. , Cairns Elizabeth , Gjerde Harald , Duff Nicole M. , Collett Keon , Ngo Mike , Nasrallah Gheyath K. , McMaster Christopher R. , Litvak Matthew , Robitaille Johane M. , Berman Jason N. 
Published: October 2019

AbstractBackgroundFamilial exudative vitreoretinopathy (FEVR) is a rare congenital disorder characterized by a lack of blood vessel growth to the periphery of the retina with secondary fibrovascular proliferation at the vascular‐avascular junction. These structurally abnormal vessels cause leakage and hemorrhage, while the fibroproliferative scarring results in retinal dragging, detachment and blindness. Mutations in the FZD4 gene represent one of the most common causes of FEVR.MethodsA loss of function mutation resulting from a 10‐nucleotide insertion into exon 1 of the zebrafish fzd4 gene was generated using transcription activator‐like effector nucleases (TALENs). Structural and functional integrity of the retinal vasculature was examined by fluorescent microscopy and optokinetic responses.ResultsZebrafish retinal vasculature is asymmetrically distributed along the dorsoventral axis, with active vascular remodeling on the ventral surface of the retina throughout development. fzd4 mutants exhibit disorganized ventral retinal vasculature with discernable tubular fusion by week 8 of development. Furthermore, fzd4 mutants have impaired optokinetic responses requiring increased illumination.ConclusionWe have generated a visually impaired zebrafish FEVR model exhibiting abnormal retinal vasculature. These fish provide a tractable system for studying vascular biology in retinovascular disorders, and demonstrate the feasibility of using zebrafish for evaluating future FEVR genes identified in humans.
Increased activity of mesenchymal ALK2‐BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues
Authors: Ishan Mohamed , Chen Guiqian , Sun Chenming , Chen Shi‐You , Komatsu Yoshihiro , Mishina Yuji , Liu Hong‐Xiang 
Published: October 2019

SummaryProper development of taste organs including the tongue and taste papillae requires interactions with the underlying mesenchyme through multiple molecular signaling pathways. The effects of bone morphogenetic proteins (BMPs) and antagonists are profound, however, the tissue‐specific roles of distinct receptors are largely unknown. Here, we report that constitutive activation (ca) of ALK2‐BMP signaling in the tongue mesenchyme (marked by Wnt1‐Cre) caused microglossia—a dramatically smaller and misshapen tongue with a progressively severe reduction in size along the anteroposterior axis and absence of a pharyngeal region. At E10.5, the tongue primordia (branchial arches 1–4) formed in Wnt1‐Cre/caAlk2 mutants while each branchial arch responded to elevated BMP signaling distinctly in gene expression of BMP targets (Id1, Snai1, Snai2, and Runx2), proliferation (Cyclin‐D1) and apoptosis (p53). Moreover, elevated ALK2‐BMP signaling in the mesenchyme resulted in apparent defects of lingual epithelium, muscles, and nerves. In Wnt1‐Cre/caAlk2 mutants, a circumvallate papilla was missing and further development of formed fungiform papillae was arrested in late embryos. Our data collectively demonstrate that ALK2‐BMP signaling in the mesenchyme plays essential roles in orchestrating various tissues for proper development of the tongue and its appendages in a region‐specific manner.
Population genomic structure of the gelatinous zooplankton species Mnemiopsis leidyi in its nonindigenous range in the North Sea
Authors: Verwimp Christophe , Vansteenbrugge Lies , Derycke Sofie , Kerkhove Thomas , Muylle Hilde , Honnay Olivier , Ruttink Tom , Roldán‐Ruiz Isabel , Hostens Kris 
Published: October 2019

AbstractNonindigenous species pose a major threat for coastal and estuarine ecosystems. Risk management requires genetic information to establish appropriate management units and infer introduction and dispersal routes. We investigated one of the most successful marine invaders, the ctenophore Mnemiopsis leidyi, and used genotyping‐by‐sequencing (GBS) to explore the spatial population structure in its nonindigenous range in the North Sea. We analyzed 140 specimens collected in different environments, including coastal and estuarine areas, and ports along the coast. Single nucleotide polymorphisms (SNPs) were called in approximately 40 k GBS loci. Population structure based on the neutral SNP panel was significant (FST .02; p < .01), and a distinct genetic cluster was identified in a port along the Belgian coast (Ostend port; pairwise FST .02–.04; p < .01). Remarkably, no population structure was detected between geographically distant regions in the North Sea (the Southern part of the North Sea vs. the Kattegat/Skagerrak region), which indicates substantial gene flow at this geographical scale and recent population expansion of nonindigenous M. leidyi. Additionally, seven specimens collected at one location in the indigenous range (Chesapeake Bay, USA) were highly differentiated from the North Sea populations (pairwise FST .36–.39; p < .01). This study demonstrates the utility of GBS to investigate fine‐scale population structure of gelatinous zooplankton species and shows high population connectivity among nonindigenous populations of this recently introduced species in the North Sea.OPEN RESEARCH BADGES

This article has earned an Open Data Badge for making publicly available the digitally‐shareable data necessary to reproduce the reported results. The data is available at: The DNA sequences generated for this study are deposited in the NCBI sequence read archive under SRA accession numbers SRR6950721–SRR6950884, and will be made publically available upon publication of this manuscript.
Temporal changes in abundance–occupancy relationships over 40 years
Authors: Manne Lisa L. , Veit Richard R. 
Published: October 2019

Abstract

Abundance–occupancy (A–O) relationships are widely documented for many organismal groups and regions, and have been used to gain an understanding of regional population and community trends. Monitoring changes in abundance and occupancy over time may be what is required to document changes in conservation status and needs for some species, communities, or areas.

We hypothesize that if there is a higher proportion of declining species in one group of species compared with another (e.g., migratory species vs. permanent residents), then a consequence of that difference will be vastly different abundance–occupancy relationships. If this difference persists through time, then the resulting A–O relationships between the groups will continue to diverge.

For neotropical migrants, short‐distance migrants, and permanent resident birds of North America, we assess the numbers of declining species over 1969–2009. We further test for differences in the A–O relationship across these three groups, and in rates of change in abundance and occupancy separately.

We find significant differences in numbers of declining species across the migratory groups, a significant decline in the A–O relationship for permanent residents, a significant increase for Neotropical migrants, and a nonsignificant decline for short‐distance migrants over the 40 years. Further, abundances are not changing at different rates but occupancies are consistently greater over time for neotropical migrants versus permanent residents, likely driving the changes in A–O relationships observed.

In these analyses, we documented changing A–O trends for different groups of species, over a relatively long time period for ecological studies, one of only a few studies to examine A–O relationships over time. Further, we have shown that a temporally unvarying abundance–occupancy relationship is not universal, and we posit that variability in A–O relationships is due to human impacts on habitats, coupled with variation in species' abilities to respond to human impacts.
Quantifying shape and ecology in avian pedal claws: The relationship between the bony core and keratinous sheath
Authors: Hedrick Brandon P. , Cordero Samantha A. , Zanno Lindsay E. , Noto Christopher , Dodson Peter 
Published: October 2019

AbstractTerrestrial tetrapods use their claws to interact with their environments in a plethora of ways. Birds in particular have developed a diversity of claw shapes since they are often not bound to terrestrial locomotion and have heterogeneous body masses ranging several orders of magnitude. Numerous previous studies have hypothesized a connection between pedal claw shape and ecological mode in birds, yet have generated conflicting results, spanning from clear ecological groupings based on claw shape to a complete overlap of ecological modes. The majority of these studies have relied on traditional morphometric arc measurements of keratinous sheaths and have variably accounted for likely confounding factors such as body mass and phylogenetic relatedness. To better address the hypothesized relationship between ecology and claw shape in birds, we collected 580 radiographs allowing visualization of the bony core and keratinous sheath shape in 21 avian orders. Geometric morphometrics was used to quantify bony core and keratinous sheath shape and was compared to results using traditional arc measurements. Neither approach significantly separates bird claws into coarse ecological categories after integrating body size and phylogenetic relatedness; however, some separation between ecological groups is evident and we find a gradual shift from the claw shape of ground‐dwelling birds to those of predatory birds. Further, the bony claw core and keratinous sheath are significantly correlated, and the degree of functional integration does not differ across ecological groups. Therefore, it is likely possible to compare fossil bony cores with extant keratinous sheaths after applying corrections. Finally, traditional metrics and geometric morphometric shape are significantly, yet loosely correlated. Based on these results, future workers are encouraged to use geometric morphometric approaches to study claw geometry and account for confounding factors such as body size, phylogeny, and individual variation prior to predicting ecology in fossil taxa.
Contribution of rare and common species to subterranean species richness patterns
Authors: Bregović Petra , Fišer Cene , Zagmajster Maja 
Published: October 2019

AbstractAimCommon species contribute more to species richness patterns (SRPs) than rare species in most studies. Our aim was to test this hypothesis using a novel model system, species living exclusively in subterranean habitats. They consist of mainly rare species (small ranges), only a few of them being common (large ranges), and challenge whether rare species are less important for the development of SRPs in this environment. We separately analyzed aquatic and terrestrial species.LocationWestern Balkans in southeastern Europe.MethodsWe assembled two datasets comprising 431 beetle and 145 amphipod species, representing the model groups of subterranean terrestrial and aquatic diversity, respectively. We assessed the importance of rare and common species using the stepwise reconstruction of SRPs and subsequent correlation analyses, corrected also for the cumulative information content of the subsets based on species prevalence. We applied generalized linear regression models to evaluate the importance of rare and common species in forming SRPs. Additionally, we analyzed the contribution of rare and common species in species‐rich cells.ResultsPatterns of subterranean aquatic and terrestrial species richness overlapped only weakly, with aquatic species having larger ranges than terrestrial ones. Our analyses supported higher importance of common species for forming overall SRPs in both beetles and amphipods. However, in stepwise analysis corrected for information content, results were ambiguous. Common species presented a higher proportion of species than rare species in species‐rich cells.Main ConclusionWe have shown that even in habitats with the domination of rare species, it is still common species that drive SRPs. This may be due to an even spatial distribution of rare species or spatial mismatch in hotspots of rare and common species. SRPs of aquatic and terrestrial subterranean organisms overlap very little, so the conservation approaches need to be habitat specific.