bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting Charge‐Carriers Dynamics by Relaxed Lattice Strain in A‐site‐Doped Halide Perovskite for Photocatalytic H2 Evolution
Authors: Guo Qing , Zhang Jin‐Dan , Liu Jia‐Mei , Chen Ya‐Jing , Qin Bin , Xia Jing , Guo Li‐Na , Duan Xin‐Hua , Wu Li‐Zhu 
Published: October 2024

AbstractBecause of the unique and superior optoelectronic properties, metal halide perovskites (MHPs) have attracted great interest in photocatalysis. Element doping strategy is adopted to modify perovskite materials to improve their photocatalytic performance. However, the contribution of bare doping‐site onto photocatalytic efficiency, and the correlation between doping locations and activity have not yet to be demonstrated. The unique properties of non‐active alkali metals promoted us to systematically explore the potential of A‐site‐doped MHPs for photocatalysis. Herein, we dope potassium (K+) into CsPbBr3 via an anti‐solvent precipitation method and first reveal that the occupied locations of K+ in CsPbBr3 is lattice incorporation rather than surface segregation, which would change from A‐site substitution to interstitial site in lattice with the increase of K+ concentrations. Taking hydrogen (H2) evolution as a model reaction, photocatalytic activity of CsPbBr3 after K+ doping could be significantly improved ~11‐fold with A‐site substitution, which is superior to that of interstitial site doping. Moreover, other alkali metals including lithium (Li), sodium (Na), and rubidium (Rb) doping give the same results. The structure of photocatalysts during reaction confirmed the contribution of A‐site doping onto enhanced photocatalytic activity. Mechanistic insights show it is a result of the relaxed lattice strain induced promoted charge‐carriers dynamics and upward shifting of band after K+ A‐site doping.
The Hard Ferromagnetism in FePS3 Induced by Non‐Magnetic Molecular Intercalation
Authors: Ou Yunbo , Li Xiaoyin , Kopaczek Jan , Davis Austin , Jackson Gigi , Sayyad Mohammed , Liu Feng , Tongay Seth Ariel 
Published: November 2024

AbstractManipulating the magnetic ground states of 2D magnets is a focal point of recent research efforts. Various methods have demonstrated efficacy in modulating the magnetic properties inherent to van der Waals (vdW) magnetic systems. Herein, the emergence of robust anisotropic ferromagnetism within antiferromagnetic FePS3 is unveiled via intercalation with non‐magnetic pyridinium ions. A one‐step ion exchange reaction facilitates the formation of energetically favorable B‐phase and metastable P‐phase. Notably, both B‐ and P‐phases manifest hard ferromagnetic behavior, featuring substantial unsaturated coercive fields (>7 T) and high Curie temperatures (72–87 K). First‐principles calculations elucidate the pivotal role of electron transfer from pyridinium ions to FePS3 in engineering magnetic exchange interactions. Calculated effective spin Hamiltonian corroborates the observed hard ferromagnetism in intercalated FePS3. This study offers crucial insights into hard magnetism in intercalated vdW materials, thereby presenting promising avenues for 2D vdW magnet‐based magnetic devices.
A Single Cell Transcriptomic Fingerprint of Stressed Premature, Imbalanced Differentiation of Embryonic Stem Cells
Authors: L Ruden Ximena , Singh Aditi , Marben Teya , Tang Wen , O Awonuga Awoniyi , Ruden Douglas M. , E Puscheck Elizabeth , Feng Hao , Korzeniewski Steven J. , A Rappolee Daniel 
Published: November 2024

ABSTRACTBackgroundMiscarriages cause a greater loss‐of‐life than cardiovascular diseases, but knowledge about environmentally induced miscarriages is limited. Cultured naïve pluripotent embryonic stem cells (ESC) differentiate into extra‐embryonic endoderm/extraembryonic endoderm (XEN) or formative pluripotent ESC, during the period emulating maximal miscarriage of peri‐implantation development. In previous reports using small marker sets, hyperosmotic sorbitol, or retinoic acid (RA) decreased naïve pluripotency and increased XEN by FACS quantitation.MethodsBulk and single cell (sc)RNAseq analyses of two cultured ESC lines was done, corroborated by qPCR. Transcriptomic responses were analyzed of cultured ESC stressed by Sorbitol, with Leukemia inhibitory factor (LIF + ; stemness growth factor), RA without LIF to control for XEN induction, and compared with normal differentiation (LIF − , ND).ResultsSorbitol and RA increase subpopulations of 2‐cell embryo‐like (2CEL) and XEN sub‐lineages; primitive, parietal, and visceral endoderm (VE) cells and suppress formative pluripotency, imbalancing alternate lineage choices of initial naïve pluripotent cultured ESC compared with ND. Although bulk RNAseq and gene ontology (GO) group analyses suggest that stress induces anterior VE‐head organizer and placental markers, scRNAseq reveals relatively few cells. But VE and placental markers/cells were in adjacent stressed cell clusters in the UMAP, like recent, normal UMAP of conceptuses. UMAPs show that dose‐dependent stress overrides stemness to force premature lineage imbalance.ConclusionsHyperosmotic stress, and other toxicological stresses, like drugs with active ingredient RA, may cause premature, lineage imbalance, resulting in miscarriages or birth defects.
Machine learning models reveal ARHGAP11A's impact on lymph node metastasis and stemness in NSCLC
Authors: Wang Xiaoli , Zhou Yan , Lu Xiaomin , Shao Lili 
Published: November 2024

AbstractMost patients with non‐small cell lung cancer (NSCLC) are diagnosed at an advanced stage of the disease, which complicates treatment due to a heightened risk of metastasis. Consequently, the timely identification of biomarkers associated with lymph node metastasis is essential for improving the clinical management of NSCLC patients. In this research, the WGCNA algorithm was utilized to pinpoint genes linked to lymph node metastasis in NSCLC. A cluster analysis was carried out to investigate how these genes correlate with the prognosis and the outcomes of immunotherapy for NSCLC patients. Following this, diagnostic and prognostic models were created and validated through various machine learning methodologies. The random forest technique highlighted the importance of ARHGAP11A, leading to an in‐depth examination of its role in NSCLC. By analyzing 78 tissue chip samples from NSCLC patients, the study confirmed the association between ARHGAP11A expression, patient prognosis, and lymph node metastasis. Finally, the influence of ARHGAP11A on NSCLC cells was assessed through cell function experiments. This research utilized the WGCNA technique to identify 25 genes that are related to lymph node metastasis, clarifying their connections with tumor invasion, growth, and the activation of stemness pathways. Cluster analysis revealed significant associations between these genes and lymph node metastasis in NSCLC, especially concerning immunotherapy and targeted treatments. A diagnostic system that combines various machine learning approaches demonstrated strong efficacy in forecasting both the diagnosis and prognosis of NSCLC. Importantly, ARHGAP11A was identified as a key prognostic gene associated with lymph node metastasis in NSCLC. Molecular docking analyses suggested that ARHGAP11A has a strong affinity for targeted therapies within NSCLC. Additionally, immunohistochemical assessments confirmed that higher levels of ARHGAP11A expression correlate with unfavorable outcomes for NSCLC patients. Experiments on cells showed that reducing ARHGAP11A expression can hinder the proliferation, metastasis, and stemness traits of NSCLC cells. This investigation reveals the novel insight that ARHGAP11A may function as a potential biomarker connected to lymph node metastasis in NSCLC. Moreover, reducing the expression of ARHGAP11A has demonstrated the ability to diminish tumor stemness characteristics, presenting a promising opportunity for improving treatment strategies for this condition.
Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases
Authors: Tao Zhenxing , Li Pengpeng , Zhao Xudong 
Published: November 2024

ABSTRACTIntroductionDexmedetomidine, a highly specific α2 agonist, has been extensively utilized in clinical sedation and surgical anesthesia since its introduction in 2000 due to its excellent sympatholytic, sedative, and analgesic effects. This review aimed to identify new approaches for the treatment of patients with brain disorders by thoroughly describing the mechanism of action of dexmedetomidine and examining its neuroprotective effects from the standpoints of basic and clinical research.MethodsThe PubMed and Web of Science databases were searched using the keywords dexmedetomidine and related brain diseases, although relevant articles from the last decade were included for detailed summarization and analysis.ResultsDexmedetomidine has shown strong neuroprotective effects, such as protection of the blood‐brain barrier, decreased neuronal death, maintained hemodynamic stability, and reduced postoperative agitation and cognitive dysfunction. Furthermore, dexmedetomidine has been shown to exert various neuroprotective effects, including anti‐inflammatory and antioxidative stress effects, modulation of autophagy, and reduction of apoptosis in cerebral diseases.ConclusionsDexmedetomidine acts as a neuroprotective agent against brain diseases during all phases of treatment. However, clinical trials with larger sample sizes are required to optimize dosage and dosing strategies.
Comparison of Time to Next Treatment or Death Between Front‐Line Daratumumab, Lenalidomide, and Dexamethasone (DRd) Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Among Transplant‐Ineligible Patients With Multiple Myeloma
Authors: Hansen Doris K. , Gautam Santosh , Lafeuille Marie‐Hélène , Rossi Carmine , Moore Bronwyn , Tardif‐Samson Anabelle , Thompson‐Leduc Philippe , Fu Alex Z. , Cortoos Annelore , Kaila Shuchita , Fonseca Rafael 
Published: November 2024

ABSTRACTIntroductionDaratumumab, lenalidomide, and dexamethasone (DRd) and bortezomib, lenalidomide, and dexamethasone (VRd) are the only preferred treatment regimens for patients with transplant‐ineligible (TIE) newly diagnosed multiple myeloma (NDMM). As there are no randomized head‐to‐head studies of DRd versus VRd, this analysis aimed to compare real‐world time‐to‐next‐treatment (TTNT) or death in this population.MethodsPatients with NDMM who received front‐line (FL) DRd or VRd were identified from the Acentrus database (January 1, 2018 to May 31, 2023). Those with a record of a stem cell transplant or aged < 65 years were excluded to limit analysis to the TIE population. Inverse probability of treatment weighting was used to balance baseline patient characteristics. A doubly robust Cox proportional hazards model was used to compare TTNT or death between cohorts.ResultsA total of 149 and 494 patients who initiated DRd and VRd, respectively, were identified. After weighting (weighted NDRd = 302, weighted NVRd = 341), cohorts had similar baseline characteristics. Of these, 98 (32.4%) DRd and 175 (51.2%) VRd patients either received a subsequent line of therapy or died, with a median TTNT or death of 37.8 months in the DRd cohort and 18.7 months in the VRd cohort (hazard ratio: 0.58, 95% confidence interval: 0.35, 0.81; p < 0.001).ConclusionTreatment of TIE NDMM patients with DRd led to a significantly longer TTNT or death compared to VRd, evidenced by a 42% risk reduction, supporting the effectiveness of DRd over VRd as FL treatment in this patient population.
Important Roles of PI3K/AKT Signaling Pathway and Relevant Inhibitors in Prostate Cancer Progression
Authors: Wang Rui , Qu Zhen , Lv Ying , Yao Lu , Qian Yang , Zhang Xiangyu , Xiang Longquan 
Published: November 2024

ABSTRACTProstate cancer (PCa) is an extremely common malignant tumor of the male genitourinary system, originating from the prostate gland epithelium. Male patients are prone to relapse after treatment, which seriously threatens their health. Phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB, also known as Akt) plays an important role in the growth, invasion, and metastasis of PCa. This review aimed to present an overview of the mechanism of action of the PI3K/AKT signaling pathway in PCa and discuss the application prospects of inhibitors of this pathway in treating PCa, providing a theoretical basis and reference for its clinical treatment targets.
Linear and Polyvalent Peptides with Potent Antimicrobial Activity Against Sensitive and Multidrug‐Resistant E. c oli Clinical Isolates
Authors: Cuero‐Amu Kelin , Daniela Bonilla‐Velásquez Laura , Vargas‐Casanova Yerly , Lucía Leal‐Castro Aura , Marcela Parra‐Giraldo Claudia , Giselle López‐Sánchez Amalia , Fierro‐Medina Ricardo , García‐Castañeda Javier , Rivera‐Monroy Zuly 
Published: November 2024

AbstractPeptides containing the sequences 20RRWQWR25 and 20RRWQWRMKKLG30 derived from Bovine lactoferricin (LfcinB) were synthesized and their antibacterial effect against reference strains and sensitive and resistant clinical isolates of E. coli was evaluated. Tetra‐branched multiple antigen peptide (MAP) ((RRWQWR)2‐K‐Ahx‐C)2 exhibited significant antibacterial activity against sensitive, resistant, and multidrug‐resistant clinical isolates of E. coli. Peptide 3: RRWQWR‐Nal‐KKLG; MIC=16 μM, 26[F]: (RRWQWRFKKLG)2‐K‐Ahx; MIC=15 μM, 17: (RRWQWRFK)2‐K‐Ahx; MIC=9 μM, and LfcinB (20–25)2: (RRWQWR)2‐K‐Ahx; MIC=11 μM exhibited the highest antibacterial activity against E. coli strains, with bactericidal effect and haemolytic effect at MIC less than 5 % and a therapeutic index >1. A synergistic effect of peptides 26[F] and 17 with ciprofloxacin (CIP) or ceftriaxone (CEF) was observed. Prolonged treatment of E. coli ATCC 25922 with sublethal concentrations of CIP induced resistance in this strain, whereas some peptides did not induce resistance. These peptides can be considered to be promising candidates for treating infections caused by resistant strains of E. coli.
Investigation into the Quantitative Structure‐Biotoxicity Relationship of Antibiotics and their Estrogenic Receptor Disruption Effects
Authors: Zhu Wanhong , Chen Shuangkou , Wang Yu , Xu Xi , Huang Xia , Yang Xin , Ren Fengming 
Published: November 2024

AbstractIn light of antibiotics being classified as environmental hormone‐like compounds, their interference with the endocrine system has significantly impacted human health and ecological environments. This study employed Density Functional Theory (DFT) within Gaussian09, conducting structural optimizations and property calculations on 23 typical antibiotic molecules at the B3LYP/3‐21G and B3LYP/6‐31G(d) levels to obtain structural parameters and acquired physicochemical property parameters through the RDKit database in ChemDes platform for quantitative processing of the compounds. Multiple linear regression analysis identified the primary factors affecting antibiotics’ biological toxicity (pLD50), and a QSAR model was established. The model's predictive capability was analyzed using leave‐one‐out cross‐validation, and the binding modes and mechanisms of action between estrogen receptors (ER) and antibiotics were investigated via molecular docking and molecular dynamics simulations. The results indicate that six property parameters significantly influence the biological toxicity of antibiotics, with the established QSAR model C exhibiting regression coefficients R2 and Q2 of 0.92474 and 0.74913, respectively, demonstrating good stability and predictive power. Molecular surface electrostatic potential, frontier molecular orbitals, molecular docking, and molecular dynamics simulations revealed that stable hydrogen bonds and hydrophobic interactions primarily mediate the potential estrogenic disrupting effects between antibiotics and estrogen receptors. Predictions from an anticancer compound library identified ten compounds with strong estrogenic disrupting effects, and molecular docking validated the practical utility of model C. This provides a valuable exploration for discovering and screening PPCPs with potential estrogenic disrupting effects.
Design, Synthesis, and Anti‐Inflammatory Activity Evaluation of Novel Indanone Derivatives for the Treatment of Vascular Dementia
Authors: Tang Xue‐Song , He Lin‐Yu , Li Sheng‐Nan , Zhang Wen‐Cheng , Wu Ze‐Yu , Hui Ai‐Ling 
Published: November 2024

AbstractVascular dementia (VaD) is a neurodegenerative disease resulting from cerebral vascular obstruction, leading to cognitive impairment, and currently lacks effective treatment options. Due to its complex pathogenesis, multi‐target drug design (MTDLs) strategies are considered among the most promising therapeutic approaches. In this study, we designed and synthesized a series of novel indanone derivatives targeting targets related to vascular health and dementia. The results indicated that compound C5 exhibited excellent acetylcholinesterase inhibitory activity (IC50 =1.16 0.41 μM) and anti‐platelet aggregation activity (IC50 =4.92±0.10 μM) within ranges of 0.1–1000 μM and 0.03–300 μM, respectively, possibly mediated by molecular docking interactions. Furthermore, compound C5 demonstrated protective effects on cells at concentrations ≤50 μM, significantly reducing the release of nitric oxide (NO), tumor necrosis factor‐alpha (TNF‐α), and interleukin‐1 beta (IL‐1β) in a concentration‐dependent manner, showcasing its potent neuroinflammatory inhibitory effects. Anti‐inflammatory therapies are regarded as effective strategies for treating VaD. Therefore, compound C5 holds promise as a novel candidate drug for further investigation into the treatment of vascular dementia.
Classification of primary mitral regurgitation using extramitral cardiac involvement in patients undergoing transcatheter edge‐to‐edge repair
Authors: Kaewkes Danon , Shechter Alon , Patel Vivek , Koren Ofir , Koseki Keita , Chakravarty Tarun , Nakamura Mamoo , Makar Moody , Makkar Raj 
Published: November 2024

AbstractBackgroundAn enhanced classification of primary mitral regurgitation (PMR) based on extramitral cardiac involvement may refine patient selection and optimize the timing of transcatheter edge‐to‐edge repair (TEER).AimsThis study aimed to assess the prognostic significance of a recently established classification system that characterizes the extent of extramitral cardiac damage in patients undergoing TEER for PMR.MethodsConsecutive PMR patients who received MitraClip implantation were categorized according to the presence of extramitral cardiac damage, determined through preprocedural echocardiography. The classifications included no damage or only left ventricular dilatation (group 0), left atrial involvement (group 1), right ventricular volume/pressure overload (group 2), right ventricular failure (group 3), or left ventricular failure (group 4). Cox‐proportional hazard models were used to ascertain the impact of PMR groups on the primary composite outcome of all‐cause mortality or rehospitalization for heart failure (HHF) over 2 years.ResultsIn a cohort of 322 eligible PMR patients undergoing TEER (median age: 83 years; 41% female) between 2013 and 2020, the following distribution emerged: group 0 (10 patients, 3%), group 1 (96 patients, 30%), group 2 (117 patients, 36%), group 3 (56 patients, 18%), and group 4 (43 patients, 13%). Kaplan‐Meier analysis demonstrated a significant decline in freedom from the primary outcome as group severity increased (log‐rank p = 0.030). On multivariate analysis, the degree of extramitral cardiac involvement was significantly associated with the primary outcome (HR: 1.30; 95% CI: 1.02–1.67; p = 0.043), primarily driven by HHF.ConclusionsThis innovative classification system for PMR, based on extramitral cardiac involvement, carries significant prognostic implications for clinical outcomes following TEER. Integrating this classification system into clinical decision‐making could enhance risk stratification and optimize the timing of TEER in these patients.
Sump syndrome: Diagnosis dilemmas and therapeutic approaches—A case series
Authors: Abbarh Shahem , Sawaf Bisher , Almasri Hussam , Balaraju Girisha , Albuni Mhd Kutaiba , Abbarah Shaher , Ahmed Ashraf I. , Ismail Abdellatif , Al Kaabi Saad Rashid Mohammad 
Published: November 2024

Key Clinical MessageIt is important to consider the diagnosis of Sump syndrome in patients with a history of open cholecystectomy, particularly in those who migrate from developing countries where alternative biliary interventions may be limited. The presentation may range from acute severe, mimicking acute ascending cholangitis, to chronic recurrent abdominal pain without evidence of inflammation. Management is a case‐by‐case decision, with principal management aims to decompress the biliary tract and address any underlying sepsis.AbstractSump syndrome is a rare and often long‐term complication of choledochoduodenostomy (CDD). The presentation and severity are variable, and management should be tailored to each patient based on several factors. Herein, we report three cases of sump syndrome, each demonstrating unique diagnostic dilemmas and therapeutic modalities. Case I describes a woman presenting with acute cholangitis, managed with percutaneous transhepatic cholangiography (PTC) and endoscopic retrograde cholangiopancreatography (ERCP). Case II illustrates a similar presentation complicated by myocardial infarction, necessitating urgent biliary decompression via PTC and subsequent unsuccessful endoscopic stenting. Case III highlights the diagnostic difficulty in a stable patient with inconclusive diagnostic imaging. This case series emphasizes the importance of considering sump syndrome diagnosis in patients with a history of CDD or open cholecystectomy, especially in elderly patients and those who come from regions where alternative biliary interventions may be limited.
Hip pain and exophthalmos in a child: Which diagnosis?
Authors: Arfa Wajdi , Ghammem Mohamed , Kamoun Khaled Anis , Jenzri Mourad , Jlalia Zied 
Published: November 2024

Key Clinical MessageThis case is a reminder that bone pain in children can reflect a general pathology or a distant lesion. Thus, it is important to look for other associated signs, such as exophthalmos in our case which led us to the diagnosis of neuroblastoma metastasized to the bone.
Necrotizing fasciitis resembled acute coronary syndrome: A case report
Authors: Sepehrinia Matin , Yousefi Faeze , Valibeygi Adib , Alkamel Abdulhakim 
Published: November 2024

Key Clinical MessageChest pain is a frequent complaint in emergency departments, with various differential diagnoses from benign to life‐threatening. Hereby, we described a 60‐year‐old man presented with chest pain and hypotension who initially misdiagnosed as acute coronary syndrome, but was ultimately diagnosed with necrotizing fasciitis. This case highlights the importance of considering rare causes of chest pain.
A rare case of systemic lupus erythematosus presenting with concurrent myocarditis, central retinal vein occlusion, and deep vein thrombosis
Authors: Fesharaki Mehrdad Jafari , Zakeri Zahra , Hosseinjani Emadoddin , Dehkordi Nastaran Raissi 
Published: November 2024

Key Clinical MessageAlthough systemic lupus erythematosus may present with broad and variable symptoms, the rare and atypical combined presentation of central retinal vein occlusion, myocarditis, and deep vein thrombosis poses a diagnostic challenge and highlights the need for a comprehensive diagnostic approach. Early diagnosis and prompt treatment help mitigate disease morbidity and mortality, and emphasize the importance of heightened clinical suspicion in complex presentations.