bluuebunny/crossref_metadata_2025_split huggingface dataset:
Más allá de los cinco correctos en la administración de medicamentos desde la percepción de los profesionales de enfermería H.N.A.A.A. 2012
Authors: Pérez Agip Diana Zunaly , Villegas Adanaqué Shirley Catherine , Mogollón Torres Flor de María 
Published: May 2019

Esta investigación tuvo como objetivo: Identificar, analizar y discutir los nuevos correctos en la administración de medicamentos desde la percepción de los profesionales de enfermería, y en base a los resultados elaborar una propuesta. Su importancia radicó en que permitió sistematizar la información sobre los nuevos correctos en la administración de medicamentos, producto de las experiencias de las enfermeras. El marco teórico conceptual está respaldada por Velandia para correctos; Carvalho para medicamentos; Morris para percepción y Nightingale para enfermería. El marco metodológico sigue un enfoque cualitativo con abordaje estudio de casos. Los sujetos fueron 7 enfermeras que laboran en el Hospital Nacional Almanzor Aguinaga Asenjo (H.N.A.A.A.), determinados por saturación; para la recolección de datos se utilizó la entrevista semiestructurada a profundidad, el procesamiento de información fue mediante el método de análisis de contenido. A lo largo de la investigación se tuvo en cuenta los principios éticos de Sgreccia y los de rigor científico por Guba y Lincoln, obteniendo como categoría: Nuevos correctos en la administración de medicamentos con las subcategorías: (1) Informar al paciente sobre el medicamento que se le administra, (2) Revisar y registrar en las fuentes primarias, (3) Obtener una historia farmacológica correcta del paciente, (4) Conservar correctamente el medicamento, (5) Preparar o diluir correctamente el medicamento, (6) Utilizar los insumos adecuados, (7) Conocer el tiempo de perfusión y (8) Aplicar medidas de bioseguridad. Arribando a la consideración final de que las enfermeras vienen implementando estos nuevos correctos a parte de los universalmente conocidos, para disminuir los efectos de medicación.
Cuidar/Cuidado de la enfermera al preescolar en el periodo postoperatorio inmediato del servicio de pediatría de un hospital local; Chiclayo, 2016
Authors: Maco Tuñoque Maria Mercedes , Azpilcueta Chapilliquen Estefani , Villarreal Ortiz Yolanda Beatriz 
Published: May 2019

La investigación fue de tipo cualitativa, con abordaje metodológico de estudio de caso, los objetivos fueron: identificar, analizar y discutir el cuidar/cuidado de la enfermera al preescolar en el período post operatorio inmediato del servicio de pediatría del Hospital Regional Docente Las Mercedes Chiclayo. Los datos se recolectaron mediante la entrevista semi-estructurada, los sujetos de estudio fueron 8 enfermeras que laboran en el servicio de pediatría del hospital en mención. Se triangularon datos con las madres y/o familiares que acompañaron a los niños en esta etapa. La muestra se determinó con la técnica de saturación y redundancia. Se obtuvieron tres categorías: Valoración y satisfacciones de necesidades básicas en el periodo post operatorio inmediato del preescolar: Prioridad en el cuidar/ cuidado, Cuidar / cuidado a través de la empatía de la enfermera al preescolar en el periodo post operatorio inmediato, Incorporando a la familia en el Cuidar/ Cuidado del preescolar post operado inmediato. Se emplearon los criterios de rigor científico de Ludke y los criterios de la bioética personalista de Sgreccia.Las experiencias de las enfermeras en el cuidar/cuidado del preescolar, en el servicio de pediatría evidencian sentimientos personales ante la situación que atraviesa el preescolar post operado, que surge por un contacto emocional en respuesta a las experiencias de brindar cuidados, generando sentimientos de satisfacción de la enfermera.
The First Two Thousand Years of Star Formation
Authors: Machida Masahiro N. , Basu Shantanu 
Published: May 2019

Abstract
Starting from a prestellar core with a size of 1.2 × 104 au, we calculate the evolution of a gravitationally collapsing core until ∼2000 yr after protostar formation using a three-dimensional resistive magnetohydrodynamic simulation in which the protostar is resolved with a spatial resolution of 5.6 × 10−3 au. Following protostar formation, a rotationally supported disk is formed. Although the disk size is as small as ∼2–4 au, it remains present until the end of the simulation. Since the magnetic field dissipates and the angular momentum is then not effectively transferred by magnetic effects, the disk surface density gradually increases, and spiral arms develop due to gravitational instability. The disk angular momentum is then transferred mainly by gravitational torques, which induce an episodic mass accretion onto the central protostar. The episodic accretion causes a highly time-variable mass ejection (the high-velocity jet) near the disk inner edge, where the magnetic field is well coupled with the neutral gas. As the mass of the central protostar increases, the jet velocity gradually increases and exceeds ∼100

. The jet opening angle widens with time at its base, while the jet keeps a very good collimation on a large scale. In addition, a low-velocity outflow is driven from the disk outer edge. A cavity-like structure, a bow shock, and several knots, all of which are usually observed in star-forming regions, are produced in the outflowing region.
Oscillation of a Small Hα Surge in a Solar Polar Coronal Hole
Authors: Cho Kyung-Suk , Cho Il-Hyun , Nakariakov V. M. , Yurchyshyn Vasyl B. , Yang Heesu , Kim Yeon-Han , Kumar Pankaj , Magara Tetsuya 
Published: May 2019

Abstract
Hα surges (i.e., cool/dense collimated plasma ejections) may act as a guide for a propagation of magnetohydrodynamic waves. We report a high-resolution observation of a surge observed with 1.6 m Goode Solar Telescope (GST) on 2009 August 26, from 18:20 UT to 18:45 UT. Characteristics of plasma motions in the surge are determined with the normalizing radial gradient filter and the Fourier motion filter. The shape of the surge is found to change from a “C” shape to an inverse “C” shape after a formation of a cusp, a signature of reconnection. There are apparent upflows seen above the cusp top and downflows below it. The upflows show rising and rotational motions in the right-hand direction, with the rotational speed decreasing with height. Near the cusp top, we find a transverse oscillation of the surge, with the period of ∼2 minutes. There is no change of the oscillation phase below the cusp top, but above the top a phase change is identified, giving a vertical phase speed about 86 km s−1. As the height increases, the initial amplitude of the oscillation increases, and the oscillation damping time decreases from 5.13 to 1.18 minutes. We conclude that the oscillation is a propagating kink wave that is possibly excited by the repetitive spontaneous magnetic reconnection.
Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls
Authors: Ormseth Michelle J. , Solus Joseph F. , Sheng Quanhu , Ye Fei , Wu Qiong , Guo Yan , Oeser Annette M. , Allen Ryan M. , Vickers Kasey C. , Stein C. Michael 
Published: May 2019

Objective.MicroRNA (miRNA) are short noncoding RNA that regulate genes and are both biomarkers and mediators of disease. We used small RNA (sRNA) sequencing and machine learning methodology to develop an miRNA panel to reliably differentiate between rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and control subjects.Methods.Plasma samples from 167 RA and 91 control subjects who frequency-matched for age, race, and sex were used for sRNA sequencing. TIGER was used to analyze miRNA. DESeq2 and random forest analyses were used to identify a prioritized list of miRNA differentially expressed in patients with RA. Prioritized miRNA were validated by quantitative PCR, and lasso and logistic regression were used to select the final panel of 6 miRNA that best differentiated RA from controls. The panel was validated in a separate cohort of 12 SLE, 32 RA, and 32 control subjects. Panel efficacy was assessed by area under the receiver operative characteristic curve (AUC) analyses.Results.The final panel included miR-22-3p, miR-24-3p, miR-96-5p, miR-134-5p, miR-140-3p, and miR-627-5p. The panel differentiated RA from control subjects in discovery (AUC = 0.81) and validation cohorts (AUC = 0.71), seronegative RA (AUC = 0.84), RA remission (AUC = 0.85), and patients with SLE (AUC = 0.80) versus controls. Pathway analysis showed upstream regulators and targets of panel miRNA are associated with pathways implicated in RA pathogenesis.Conclusion.An miRNA panel identified by a bioinformatic approach differentiated between RA or SLE patients and control subjects. The panel may represent an autoimmunity signature, perhaps related to inflammatory arthritis, which is not dependent on active disease or seropositivity.
Multimorbidity in Axial Spondyloarthropathy and Its Association with Disease Outcomes: Results from the Ankylosing Spondylitis Registry of Ireland Cohort
Authors: Fitzgerald Gillian , Gallagher Phil , O’Shea Finbar D. 
Published: May 2019

Objective.Multimorbidity, the coexistence of 2 or more conditions in an individual, is associated with morbidity and mortality in the general population. This study aims to describe the prevalence of multimorbidity in axial spondyloarthropathy (axSpA) and assess its association with disease outcome measures.Methods.This cross-sectional study was conducted within the Ankylosing Spondylitis Registry of Ireland (ASRI) cohort. Structured standardized assessment was performed. Multimorbidity was considered as the presence of at least 1 physician-diagnosed chronic condition (excluding extraarticular manifestations) in addition to axSpA. Validated outcome measures were collected: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), Health Assessment Questionnaire (HAQ), AS Quality of Life (ASQoL), and Bath AS Metrology Index (BASMI). Adjusted multiple regression was performed to investigate the association between multimorbidity and disease outcomes.Results.A total of 734 patients from 12 centers were included: 77% male, mean (SD) age 45 (12) years. Of the cohort, 55% (n = 403) were multimorbid. Multimorbid patients were significantly (p < 0.01) older than axSpA-only patients [50 (12) vs 40 (11) yrs]. Obesity was the most prevalent chronic condition, affecting 27%. Multimorbid patients had more severe disease than patients with axSpA only. After adjusting for confounders, multimorbidity was associated with higher BASDAI (ß 0.7, 95% CI 0.34–1.05), BASMI (ß 0.45, 95% CI 0.09–0.80), BASFI (ß 0.5, 95% CI 0.23–0.78), HAQ (ß 0.07, 95% CI 0.00–0.13), and ASQoL (ß 0.87, 95% CI 0.28–1.46).Conclusion.Multimorbidity is prevalent in axSpA and is associated with more severe disease.
Sjögren Syndrome without Focal Lymphocytic Infiltration of the Salivary Glands
Authors: Sharma Rohan , Chaudhari Kaustubh S. , Kurien Biji T. , Grundahl Kiely , Radfar Lida , Lewis David M. , Lessard Christopher J. , Li He , Rasmussen Astrid , Sivils Kathy L. , Scofield R. Hal 
Published: May 2019

ObjectivePrimary Sjögren syndrome (SS) is characterized by a focal lymphocytic infiltrate in exocrine glands. We describe patients who lacked this key feature.Methods.We evaluated patients with sicca in a comprehensive clinic at which medical, dental, and ophthalmological examinations were performed. All subjects underwent a minor salivary gland biopsy with focus score calculation. Extraglandular manifestations were also determined. We categorized subjects as high, intermediate, or low in terms of expression of interferon (IFN)-regulated genes.Results.About 20% (51 of 229, 22%) of those classified as having primary SS had a focus score of zero. Compared to those with anti-Ro positivity and a focus score > 1.0, the patients with focus score of zero (who by classification criteria must be anti-Ro–positive) were statistically less likely to have anti-La (or SSB) and elevated immunoglobulin, as well as less severe corneal staining. The focus score zero patients were less likely to have elevated expression of IFN-regulated genes in peripheral blood mononuclear cells than anti-Ro–positive SS patients with a focal salivary infiltrate.Conclusion.There are only a few clinical differences between patients with primary SS with focus score zero and those with both anti-Ro and a focus score > 1.0. The small subset of focus score zero patients tested did not have elevated expression of IFN-regulated genes, but did have systemic disease. Thus, extraglandular manifestations are perhaps more related to the presence of anti-Ro than increased IFN. This may have relevance to pathogenesis of SS.
Association of Childhood Abuse with Incident Systemic Lupus Erythematosus in Adulthood in a Longitudinal Cohort of Women
Authors: Feldman Candace H. , Malspeis Susan , Leatherwood Cianna , Kubzansky Laura , Costenbader Karen H. , Roberts Andrea L. 
Published: May 2019

Objective.Exposure to severe stressors may alter immune function and augment inflammation and cytokine release, increasing risk of autoimmune disease. We examined whether childhood abuse was associated with a heightened risk of incident systemic lupus erythematosus (SLE).Methods.Data were drawn from the Nurses’ Health Study II, a cohort of US female nurses enrolled in 1989, followed with biennial questionnaires. We measured childhood physical and emotional abuse with the Physical and Emotional Abuse Subscale of the Childhood Trauma Questionnaire and sexual abuse with the Sexual Maltreatment Scale of the Parent-Child Conflict Tactics Scale, both administered in 2001. We identified incident SLE (≥ 4 American College of Rheumatology 1997 classification criteria) through 2015. We used multivariable Cox regression models to evaluate the association between childhood abuse and SLE, accounting for potential confounders (e.g., parental education, occupation, home ownership) and mediators [e.g., depression, posttraumatic stress disorder (PTSD)].Results.Among 67,516 women, there were 94 cases of incident SLE. In adjusted models, exposure to the highest versus lowest physical and emotional abuse was associated with 2.57 times greater risk of SLE (95% CI 1.30–5.12). We found that 17% (p < 0.0001) of SLE risk associated with abuse could be explained by depression and 23% (p < 0.0001) by PTSD. We did not observe a statistically significant association with sexual abuse (HR 0.84, 95% CI 0.40–1.77, highest vs lowest exposure).Conclusion.We observed significantly increased risk of SLE among women who had experienced childhood physical and emotional abuse compared with women who had not. Exposure to childhood adversity may contribute to development of SLE.
Visages anonymes
Authors: Luttway Diane 
Published: May 2019

Connaître quelqu’un, c’est associer un nom et un visage : si l’un des deux manque, c’est comme si la personne nous échappait ; mais mettre un nom comme on colle une étiquette sur une chose et croire ainsi connaître alors qu’on ne fait qu’identifier, c’est renoncer à l’étonnement face au mystère de l’ipséité captée dans la perception du visage. Afin de l’élucider, il faut se faire phénoménologue et suivre les analyses de Sartre sur le regard ainsi que celles de Levinas sur le visage.
La reine des Marolles et le Roi des Belges : anonymat et souveraineté populaire
Authors: Carton de Grammont Sarah 
Published: May 2019

Que se joue-t-il au Bal National, à la veille de la passation des pouvoirs d’Albert II à Philippe ? Par quel reenactment le peuple belge est-il le peuple belge ? Quel rôle joue la tension entre anonymat et singularisation dans l’incarnation de la souveraineté populaire ? De trémolos en trémoussements, danseurs et danseuses d’un soir se dotent d’un Roi des Belges – et de leur voix dans le Concert des Nations.
Hélas, tourment que j’occulte. Pour une raison trop claire…
Authors: Quint Anne-Marie 
Published: May 2019

Le roman anonyme Naceo e Amperidónia complète la liste des œuvres de fiction écrites en portugais au xvi e siècle. Cette histoire, simple, comporte des épisodes narratifs, mais les échanges entre les protagonistes sont surtout épistolaires. Son auteur, quel qu’il soit, y révèle une solide culture, ainsi qu’une grande maîtrise des usages de la cour et du langage mondain, surtout des jeux littéraires en vogue dans les milieux aristocratiques.
Les crânes et le cochon qui danse
Authors: Reinert Hugo 
Published: May 2019

Fin 2017. Pour protester contre l’abattage forcé des troupeaux de rennes indigènes en Norvège, une jeune artiste sámi s’est rendue à Oslo pour installer un « rideau » de 400 crânes de rennes devant le Parlement national. La manifestation a trouvé un écho considérable à l’échelle nationale et internationale et a mobilisé une gamme complexe de résonances historiques – des premières manifestations des Sámi contre le projet hydroélectrique Alta, il y a un demi-siècle, aux vastes piles de crânes de bison symboliques de la campagne américaine contre les Indiens des Plaines au xixe siècle. En resituant l’installation artistique du rideau dans un contexte de violence étatique chronique, d’invisibilité autochtone et de biopolitique de crise, cet article examine les multiples logiques apocalyptiques évoquées par l’œuvre.
Silicium prophétie
Authors: Grimaud Emmanuel 
Published: May 2019

La singularité technologique est-elle vraiment « la moins pire des prophéties » comme le dit Vernor Vinge ? L’alliance du genre humain avec la technologie ne peut-elle que conduire à sa propre dissolution ? Faut-il souhaiter sa disparition ? Telles sont quelques-unes des questions que soulève la théorie de Vinge qui a déclenché jusqu’ici soit l’adhésion naïve, soit le rejet violent ou bien l’indifférence. Ce commentaire du premier essai de Vinge sur le concept de singularité technologique cherche à saisir les mécanismes d’emprise paradoxale de la prophétie. Il la resitue de fait par rapport à d’autres scénarios (Point Omega, Digital Gaïa, etc.), variantes technoprophétiques qui extrapolent les seuils critiques de notre temps pour le meilleur et pour le pire.
Effects of PI3K Inhibition on Afucosylated Antibody–Driven FcγRIIIa Events and Phospho-S6 Activity in NK Cells
Authors: Romeo Valentina , Gierke Sarah , Edgar Kyle A. , Liu Scot D. 
Published: May 2019

Abstract
PI3K is one of the most frequently mutated genes in cancers and has been the target of numerous anticancer therapies. With the additional development of therapeutics that mobilize the immune system, such as Abs with effector functions, bispecific Abs, and checkpoint inhibitors, many small molecule inhibitors that target PI3K are being combined with these immunomodulatory treatments. However, the PI3K pathway is also essential for lymphocyte function, and the presence of the PI3K inhibitor may render the immunomodulatory therapeutic ineffective in these combinatorial treatments. Therefore, therapeutics with enhanced activity, such as afucosylated Abs, which promote signaling and function, may be ideal in these types of treatments to offset the negative effect of PI3K inhibitors on immune cell function. Indeed, we show that afucosylated Abs can counterbalance these inhibitory effects on FcγRIIIa-driven signaling in human NK cells to produce signals similar to cells treated only with fucosylated Ab. Furthermore, NK cell activation, degranulation, chemokine/cytokine production, and Ab-dependent cellular cytotoxicity were similar between inhibitor-treated, afucosylated Ab–stimulated NK cells and cells activated only with its fucosylated counterpart. To our knowledge, these studies also identified a previously undefined role for phospho-S6 in human NK cells. In this study, a kinetic delay in PI3K-driven phosphorylation of S6 was observed to control transcription of the temporally regulated production of IFN-γ and TNF-α but not MIP-1α, MIP-1β, and RANTES. Together, these studies demonstrate the importance of the PI3K pathway for S6 phosphorylation in human NK cells and the need to combine PI3K inhibitors with therapeutic molecules that enhance immunomodulatory function for anticancer therapies.
Implementing a Communication Model to Enhance Patient-Centered Care
Authors: Jazieh Abdul Rahman , Al Sudairy Reem , Al Shami Mona , Yaqub Abdullah , Al Khesaifi Areej , Al-Dorzi Hasan M. , Fayad Maha 
Published: May 2019

Abstract
Background: Family involvement is essential in providing patient-centered care. It is very challenging to adapt into the health-care system. Our project aims at implementing a culturally tailored communication model to systematically involve a family in patient care. Materials and Methods: A multidisciplinary team was established to implement our previously developed communication model. We used rapid plan–do–study–act (PDSA) cycles of improvement to test the set of interventions to incorporate learned lessons into the project activities. The communication model was implemented in stages starting from the emergency department (ED) and expanding to different hospital units. Result: Fifteen PDSA cycles were conducted in the ED, intensive care unit, and inpatient wards. A clear algorithm on how to appoint the most responsible family members was developed and points of communication with the family were identified. Educational materials were developed for patients and families in addition to staff education about the program. There was a strong acceptance of the concept from families and staff, and the process is being implemented into our electronic health records. Conclusion: Our communication model was well accepted by patients, their families, and our staff. The plan is to automate the process for sustainability by making it an integral component of the electronic medical records and to introduce it throughout our system.
Need for Risk Management and Regular Occupational Health Safety Assessment Among Workers of Developing Countries
Authors: Singh Zorawar , Sekhon Pramjit Singh 
Published: May 2019

Abstract
Occupational health is a sensitive area in many developing countries where occupational exposure needs attention due to lack of awareness among industrialists as well as workers. Industries such as iron, textile, leather, and paper use a vast number of toxic chemicals during different industrial processes. Workers of these industries come in direct contact with these chemicals including dyes, solvents, and finishers, which are known to be mutagenic and genotoxic. In the absence of risk assessment programs, these chemicals pose serious health risks. Risk management is one of the key factors in health safety of the workers. Agencies of central, state, and local levels need to work harder in the field of occupational health and safety. These agencies should develop relevant risk assessment programs to minimize the exposure health impacts. In the present article, various exposure risks to workers of different industries including iron, textile, leather, and paper industry along with levels of risk management system and the need for regular health assessment programs have been discussed to put them into real practice.