bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional anaesthesia research priorities: a Regional Anaesthesia UK (RA‐UK) priority setting partnership involving patients, carers and healthcare professionals
Authors: Lewis Owen , Lloyd James , Ferry Jenny , Macfarlane Alan J. R. , Womack Jonathan , El‐Boghdadly Kariem , Shelton Clifford L. , Schaff Olivia , Quick Tom J. , Smith Andrew F. , Cannons Karin , Pearson Annabel , Heelas Leila , Rodger Daniel , Marshall John , Pellowe Carol , Bowness James S. , Kearns Rachel J. 
Published: November 2024

SummaryIntroductionRegional anaesthesia provides important clinical benefits to patients but is underutilised. A barrier to widespread adoption may be the focus of regional anaesthesia research on novel techniques rather than evaluating and optimising existing approaches. Research priorities in regional anaesthesia identified by anaesthetists have been published, but the views of patients, carers and other healthcare professionals have not been considered previously. Therefore, we launched a multidisciplinary research priority setting partnership that aimed to establish key regional anaesthesia research priorities for the UK.MethodsResearch suggestions from key stakeholders (defined by their interaction with regional anaesthesia) were gathered using an online survey. These suggestions were analysed to identify common themes and then combined to formulate indicative research questions. After an extensive literature review, unanswered and partially answered questions were prioritised via an interim online survey and then ranked as a top 10 list during a final live virtual multidisciplinary prioritisation workshop.ResultsIn total, 210 individuals completed the initial survey and suggested 518 research questions. Fifty‐seven indicative questions were formed, of which three were considered fully answered after literature review and one not feasible. The interim online survey received 335 responses, which identified the 24 highest priority questions from the 53 presented. At the final live prioritisation workshop, through a nominal group process, we identified the top 10 regional anaesthesia research priorities. These aligned with three broad thematic areas: pain management (two questions); patient safety (six questions); and recovery from surgery (two questions).DiscussionThis initiative has resulted in a list of research questions prioritised by patients, carers and a multidisciplinary group of healthcare professionals that should be used to inform and support future regional anaesthesia research in the UK.
Avascular necrosis in sickle cell disease needs more definitive treatment options
Authors: Galadanci Najibah A. , Kanter Julie 
Published: November 2024

Avascular necrosis (AVN) is a bone disease caused by a temporary or definitive loss of the blood supply to bone resulting in cellular death. In people with sickle cell disease (SCD), AVN is one of the most common causes of severe chronic pain. Currently, there are very few treatment options for AVN and the current study by Casale et al. demonstrates how the use of patient‐reported outcomes can bring us one step closer to identifying optimal treatments for this debilitating condition in SCD.Commentary on: Casale et al. Long‐term outcomes of Avascular Necrosis in Sickle Cell Disease using joint‐specific patient‐reported outcome measures: Results from a multicentre study. Br J Haematol 2025; 206:310‐319.
TRIM47 promotes hypopharyngeal and laryngeal cancers progression through promoting K63‐linked ubiquitination of vimentin
Authors: Qin Shichao , Chang Fen , Sun Xiangkai , Li Zinan , Wang Yin , Lei Dapeng 
Published: November 2024

AbstractHypopharyngeal and laryngeal cancers which belong to head and neck squamous cell carcinoma (HNSCC) are the two most malignant types of head and neck cancer, characterized by a low 5‐year survival rate, high recurrence and metastasis rate. It is vital to explore strategies to suppress metastasis and improve prognosis for patients with these cancers. In this research, we analyzed the clinical data and found that E3 ubiquitin ligase TRIM47 was upregulated in cancer tissues of hypopharyngeal cancer and was closely associated with poor survival outcomes. In terms of mechanism, we performed tandem affinity chromatography and denatured Ni‐NTA Agarose pulldown. As a result, TRIM47 was found to interact with vimentin and control vimentin stabilization through ubiquitination, specifically in the form of K63 chains. Importantly, through experiments of cancer cell viability and migration, we found that TRIM47 could enhance the proliferation and metastasis abilities of cancer cells in a vimentin‐dependent manner, thus promoting the advancement of hypopharyngeal and laryngeal cancers. TRIM47 was verified to regulate cancer cells metastasis in vivo using metastasis models. All these results imply that TRIM47 emerges as a potential biomarker for early diagnosis and metastasis prediction of hypopharyngeal and laryngeal cancers and represents a promising therapeutic target.
Integrin‐α5 expression and its role in non‐small cell lung cancer progression
Authors: Ka Mirei , Matsumoto Yoko , Ando Takahiro , Hinata Munetoshi , Xi Qian , Sugiura Yuriko , Iida Takahiro , Nakagawa Natsuki , Tokunaga Masakatsu , Watanabe Kousuke , Kawakami Masanori , Ushiku Tetsuo , Sato Masaaki , Oda Katsutoshi , Kage Hidenori 
Published: November 2024

AbstractIntegrins are transmembrane receptors that facilitate cell adhesion to the extracellular matrix and neighboring cells. Aberrant expression of integrins has been associated with tumor progression and metastasis in various cancer types. Integrin alpha‐5 (ITGA5) is an integrin subtype that serves as a receptor for fibronectin, fibrinogen, and fibrillin‐1. The purpose of this study was to elucidate how ITGA5 expression plays a role in human non‐small cell lung cancer (NSCLC). Our clinical data, along with data retrieved from The Cancer Genome Database (TCGA), revealed that high ITGA5 expression in NSCLC patients was associated with a lower recurrence‐free survival and overall survival. In our in vitro functional assays, ITGA5 overexpression in human NSCLC cell lines resulted in increased cell size, adhesion, and migration properties, while knockdown of ITGA5 restored the phenotypes. Correspondingly, knockdown and inhibition of ITGA5 in endogenously high‐expressing NSCLC cell lines resulted in decreased cell size, adhesion, migration, and proliferation. The antiproliferative effect was also confirmed by a reduction in Ki‐67 without discernible changes in apoptosis. Collectively, these findings reveal the significant role of ITGA5 in various functional behaviors in NSCLC, providing a potential therapeutic target for NSCLC patients with high ITGA5 expression.
Biodiversity offset conditions contributing to net loss of koala Phascolarctos cinereus habitat
Authors: Tran Hao Nguyen , Maron Martine 
Published: November 2024

AbstractAustralia's offset framework requires that permitted development impacts on nationally threatened species should be fully counterbalanced using biodiversity offsets. The current offsets framework was established in 2012, the same year that the iconic koala Phascolarctos cinereus was listed as threatened. We examined every development impact on koala habitat that was permitted under national biodiversity laws (the EPBC Act 1999) from 2012 until the end of 2021, shortly after which the koala was uplisted from vulnerable to endangered (n = 98). We analyzed the application of the national environmental offset framework in each case. In this period, more than 25,000 hectares of koala habitat were approved for removal, most in the state of Queensland (96%) and for mining (76%). Although most clearing of koala habitat is attributable to agricultural activity and ostensibly requires approval under the EPBC Act, we found zero referrals for agricultural clearing. A total of 62 projects included offset requirements for koalas, but for only 14 projects could we find details used in the offset calculation. All but one appeared to include implausibly optimistic assumptions or logical errors that inflated the estimated benefit from the offset. After modifying the calculations to align with best practice guidance, we found only two of the 14 projects were likely to fully offset their impacts on koalas (average 55% of impact offset). The most common issues were overestimated benefits from averted losses and double‐counting of benefits. We conclude transparency around offset requirements is generally poor, and most biodiversity offsets for koalas are unlikely to fully counterbalance losses. Despite sound, long‐established policy, poor implementation means that even offsets for impacts on a highly valued species, for which offsets are ecologically plausible, are prone to failure.
Comparison of the impact of type 1 and type 2 diabetes on quality of life of families of patients: A UK cross‐sectional study
Authors: Shah Rubina , Finlay Andrew Y. , Ali Faraz M. , Otwombe Kennedy , Nixon Stuart J. , George Lindsay , Evans Marc , Ingram John R. , Salek Sam 
Published: November 2024

AbstractAimTo measure the impact of type 1 and 2 diabetes mellitus (T1D and T2D) on the QoL of a person's family members/partner and assess if there is any difference in family impact.MethodsA cross‐sectional study, recruited online through patient support groups, involved UK family members/partners of people with diabetes completing the Family Reported Outcome Measure‐16 (FROM‐16).ResultsTwo hundred and sixty‐one family members/partners (mean age = 57.9 years, SD = 13.8; females = 68.2%) of people with diabetes (mean age = 57.7, SD = 20.6; females = 38.3%; T1D n = 100; T2D n = 161) completed the FROM‐16. The overall FROM‐16 mean score was 10.47, SD = 7.8, suggesting a moderate effect on the QoL of family members of people with diabetes. A quarter (24.5%) of family members experienced a ‘very large effect’ or ‘extremely large effect’ on their QoL. The family impact of T1D (mean FROM‐16 = 12.61, SD = 7.9) was greater than that of T2D (mean = 9.15, SD = 7.5, p < 0.01), with being ‘female’ and ‘parents of children and adolescents’ rendered as significant predictors of greater impact. Family members of T2D had a lower risk of experiencing a high family impact (FROM‐16 score >16) compared with T1D (RR 0.561, 95% CI 0.371–0.849).ConclusionsCompared to T2D, family members of T1D experience a greater impact on their QoL, particularly those caring for children and adolescents. These findings have clinical and resource implications, indicating a need to assess this impact as a part of routine diabetes care to support impacted family members. The FROM‐16 could assess this impact in routine practice and further facilitate referral of family members to appropriate support services.
Redefining Higher Education Institutions (HEIs) in the Era of Globalisation and Global Crises: A Proposal for Future Sustainability
Authors: Ul Hassan Mehboob , Murtaza Ammara , Rashid Khalid 
Published: November 2024

ABSTRACTHigher Education Institutions are undergoing (HEIs) profound transformations in response to the challenges posed by globalization and the increasing frequency of global crises. This paper presents a comprehensive framework aimed at redefining the values, missions, and goals of HEIs to ensure their sustained relevance and effectiveness in addressing contemporary global challenges. Drawing upon an extensive literature review, this research examines the multifaceted roles of HEIs in fostering global citizenship, inclusivity, and innovation. Moreover, insights from the World Economic Forum's Global Risks Report 2020 underscore the urgent need for HEIs to adapt to evolving global dynamics, including pandemics, climate change, and economic volatility. The proposed framework emphasises the imperative for HEIs to align their missions with emerging global challenges, as highlighted in UNESCO's Futures of Education report. By prioritising research, education, and community engagement for global impact, HEIs can serve as proactive agents of positive change in an increasingly interconnected world. Additionally, insights from the Institute of International Education's Open Doors Report on International Educational Exchange 2021 and data from Universities UK (2020) provide valuable perspectives on internationalisation and the evolving landscape of higher education. Lastly, this paper argues that HEIs must adopt a proactive approach to adaptation and innovation to fulfil their transformative potential in the face of globalisation and global crises. By redefining their values, missions, and goals in line with contemporary challenges, HEIs can play a central role in shaping a sustainable and inclusive future.
Preschool Children's Social Problem‐Solving in Hungary and Vojvodina Based on Parents' and Teachers' Opinions
Authors: Teodóra Szitás , Zita Gál , László Kasik 
Published: November 2024

ABSTRACTThe aim of the study was to explore parents' and teachers' opinions about preschoolers' social problem‐solving and the role of parents' educational attainment and family structure in social problem‐solving, comparing these results in Hungary (n = 162) and Vojvodina (n = 147). We used Strengths and Difficulties Questionnaire (SDQ) and Social Problem‐Solving Parent/Teacher Questionnaire (SPSQ) for the latter drawing on the social problem‐solving model of Chang et al. which has two processes, problem orientation (positive, negative) and three problem‐solving styles (rational, impulsive, avoidant). Based on the results, parents' and teachers' evaluations are generally different, in both samples' parents perceive children as much more prosocial than teachers, and teachers have a more negative perception of children's attitude towards problem‐solving than parents. The triangulation research—where mothers, fathers and teachers evaluated the children—revealed several differences in the perceptions of parents and teachers in Vojvodina and Hungary. One of our findings from the comparison showed that frequency of positive problem orientation in SPS was differently perceived in both samples by the raters: according to which Vojvodina mothers and fathers found these higher in 4‐year‐olds, additionally in 5‐year‐olds by fathers, while in Hungary, this was perceived only by teachers in 5‐ and 6‐year‐olds. In both the Hungarian and the Vojvodina samples, parental education explained the psychological factors examined differently. The main message of the research is that there are significant differences in the perceptions of both parents and teachers, but also of mothers and fathers in both samples, and this is particularly true in the case of externalising problems.
Cracking Sensitivity Analysis of Red Clay With Pre‐Crack Under Three‐Point Bending
Authors: Ma Hongyan , Yan Xiaobin , Cheng Peiyuan , Xu Song , Zhang Yanping , Li Sihan 
Published: November 2024

ABSTRACTRed clay is highly susceptible to cracking due to its nature, and the reduction in strength caused by cracking can lead to engineering disasters. To investigate the cracking sensitivity of red clay, a homogeneous fracture model of red clay based on the cohesive zone model was established using ABAQUS in this work, the reliability of the model was verified through a three‐point bending test, and then the crack propagation process and sensitivity to test factors of red clay were further analyzed. The results show that the fracture simulation of the cohesive zone model is in good agreement with the test results, confirming by the high reliability. The depth of prefabricated cracks and fulcrum spacing had the significant effects on the crack path, and the decrease of prefabricated crack depth and fulcrum spacing led to the increase of critical load. Meanwhile, the loading rate had little effect on the load–displacement curves.
Lowering hot isostatic pressing temperature of ultrafine‐grained MgAl2O4 transparent ceramics by two‐step pre‐sintering
Authors: Mao Junyan , Yang Hongbin , Wang Yan , Luo Haoming , Dong Yanhao , Zhang Jian , Wang Shiwei 
Published: November 2024

AbstractCubic‐phase magnesium‐aluminum spinel (MAS) has attractive optical, mechanical, and thermal properties and has been widely used as transparent ceramics in a number of applications. However, the processing of MAS transparent ceramics typically requires pre‐sintering and hot isostatic pressing (HIP) both at very high temperatures (e.g., above 1600°C) over an extended time, which coarsens the microstructure thus impairing mechanical properties. There is an urgent need to lower the sintering temperature while maintaining high optical transparency. Here we reported new progress in combining two‐step sintering in the pressureless pre‐sintering step and low‐temperature HIP in the post‐treatment step, using high‐quality green bodies produced by pressure filtration. With this strategy, high‐quality MAS transparent ceramics are delivered. The main benefits include 200°C lower HIP temperature, a 33% smaller average grain size of 350 nm, and a higher hardness of 14.8 GPa. Such a method could be extended to many other transparent ceramics.
Regional Disparities and the Localisation of the Sustainable Development Goals in the EU
Authors: Pop Daniel , Stamos Iraklis 
Published: November 2024

AbstractThis article examines the territorialisation of the Sustainable Development Goals (SDGs) within the European Union by analysing key indicators at the national and regional (NUTS2) levels, identified by cross‐referencing the 2023 EU SDG monitoring report, and the regional SDG indicators developed by the Joint Research Centre. The analysed indicators measure progress towards poverty reduction, healthcare access, education engagement, employment, and research and development investment. Our findings suggest that whilst there is an overall trend towards achieving the SDGs at the national level, there are considerably larger disparities and more pronounced mixed trends at the NUTS2 level. These findings underscore the importance of implementing place‐based policies that consider regional particularities. Enhanced data collection at the regional level is essential to tailor effective SDG strategies. The article concludes with a call for inclusive governance to ensure equitable and sustainable development across all EU regions, aligning with the EU Territorial Agenda 2030.
The Acceptability and Effects of Internet‐Based Cognitive Behavioral Therapy on Depressive Symptoms and Remission in 13‐ to 17‐Year‐Old Adolescents: A Systematic Review and Meta‐Analysis
Authors: Liu Pei , Situ Mingjing , Duan Xiaoxia , Sun Huan , Wang Meiwen , Tao Yujie , Luo Tingting , Li Sixun , Wang Zhuo , Huang Yi 
Published: November 2024

ABSTRACTObjectiveThis study aimed to evaluate the acceptability and effects of internet‐based cognitive behavioral therapy (iCBT) or CBT‐oriented interventions compared with control groups on depressive symptoms, remission of depression, and quality of life (QOL) in adolescents.MethodsWe searched English and Chinese databases for randomized controlled trials up to October 10, 2024 that investigated the effects of iCBT compared with controls in adolescents exhibiting elevated depressive symptoms or diagnosed with depression. Standardized mean differences (SMDs), relative risks (RRs), and 95% confidence intervals were applied to evaluate the pooled effects of outcomes.ResultsA total of 19 RCTs involving 3574 cases were included in this study. We found small effects on depressive symptoms severity at different time points (posttest: SMD = –0.49 [–0.66, –0.33]; 3‐month follow‐up [FU3]: SMD = –0.21 [–0.30, –0.11]; FU6: SMD = –0.18 [–0.35, –0.02]; FU12: SMD = –0.38 [–0.56, –0.20]). We also found a significant effect in depression remission rate at the posttest (RR = 1.74 [1.36, 2.21]) and a significant effect in QOL at the posttest (SMD = 0.30 [0.07, 0.54]). However, the result regarding acceptability was nonsignificant (RR = 1.22 [0.76, 1.97]). No significant publication bias was found in these results.ConclusioniCBT or internet‐based CBT‐oriented interventions can effectively reduce depressive symptom severity and improve depression remission rate and QOL in depressed adolescents. These results are preliminary and require further validation through future systematic reviews.
Association Between Oral Hypofunction and Maximum Gait Speed in Older Adults: A Cross‐Sectional Study
Authors: Nukaya Yukiko , Matsui Daisuke , Watanabe Isao , Ozaki Etsuko , Yamamoto Toshiro , Takashima Naoyuki , Kanamura Narisato 
Published: November 2024

ABSTRACTBackgroundPrevious studies have reported an association between oral hypofunction and normal gait speed as a marker for physical function; however, the association between maximum gait speed as a more sensitive marker for physical function and poor oral function has not been investigated.ObjectivesTo elucidate associations of oral hypofunction, comprising seven elements, with both normal and maximum gait speeds in an older population.MethodsParticipants were recruited in 2018 from a hospital‐based health checkup in Kyoto Prefecture. Seven oral function tests (oral hygiene, oral dryness, occlusal force or number of teeth, tongue–lip motor function, tongue pressure, masticatory function and swallowing function) were performed. Oral hypofunction was defined as an abnormality in at least three of these items. Gait speed was measured as normal and maximum gait speeds. The relationship between oral hypofunction and maximum gait speed was analysed using logistic regression.ResultsThis study included 198 participants (130 men and 68 women; mean age: 75.0 years). Among them, 152 (76.7%) had oral hypofunction. After adjustment for age, sex and body mass index, oral hypofunction was significantly associated with a low maximum gait speed (odds ratio: 2.75, 95% confidence interval: 1.41–5.37).ConclusionOral hypofunction is associated with maximum gait speed in older people. The prevention of oral hypofunction may help maintain walking speed and promote an increase in healthy life expectancy.
Contribution of HPV Status for Neutrophil Extracellular Traps Release in Oropharyngeal Cancer
Authors: da Costa Adriana Aparecida Silva , Oliveira Sicília Rezende , Tavares Thalita Soares , Meirelles Daniela Pereira , da Silva Evânio Vilela , da Silva Anderson Tangerino Ferreira , León Jorge Esquiche , Cardoso Sérgio Vitorino , de Aguiar Maria Cássia Ferreira , da Silva Tarcília Aparecida , Caldeira Patrícia Carlos 
Published: November 2024

ABSTRACTBackgroundOropharyngeal squamous cell carcinoma (OP‐SCC) represents a public health problem and human papillomavirus (HPV) is one of the risk factors. Neutrophil extracellular traps (NET) are meshes of DNA strands and granule proteins. NET has been identified in diverse cancers, whether associated with viruses or not. However, there is no information on NET in OP‐SCC. We aimed to evaluate the NET release by neutrophils in the OP‐SCC microenvironment, stratified by HPV status.MethodsThis cross‐sectional study analyzed OP‐SCC biopsy specimens diagnosed from 1997 to 2021. HPV status was determined by p16 immunohistochemistry and “in situ” hybridization. Neutrophils were detected by CD66b immunohistochemistry. Immunofluorescence was used to identify NET by co‐localization of myeloperoxidase (MPO) and citrullinated histone H3 (H3Cit). Bivariate statistics, Kaplan–Meier survival analysis, and the log‐rank test were performed.ResultsHPV‐positive and HPV‐negative OP‐SCC had similar CD66b + neutrophil infiltration (p > 0.05), but the release of NET was significantly increased in HPV‐positive compared to HPV‐negative OP‐SCC samples (p < 0.05). Overall survival was not impacted by NET indexes (p > 0.05).ConclusionThe presence of HPV may stimulate NET release in the OP‐SCC microenvironment.