bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustic focussing for sedimentation-free high-throughput imaging of microalgae
Authors: Hammarström Björn , Vassalli Massimo , Glynne-Jones Peter 
Published: September 2019

Abstract
Microalgae play a key role in aquatic ecology, and methods providing species determination and enumeration can provide critical information about—for instance—harmful algae blooms (HABs) or spreading of invasive species. A crucial step in current methods is the use of sedimentation. This provides the enrichment needed to achieve statistical counts of sometimes rare species within reasonable timeframes, but it comes with the drawback of aggregating the sample. This is a real challenge for computer-aided identification as particle aggregates can often be erroneously classified. In this paper, we propose an alternative method based on flow-through imaging aided by acoustic-focussing, as this provides better input-data for automated counting-methods while simultaneously removing the need for manual sample preparation. We demonstrate that by acoustically focussing microalgae and other particulates in a fast-flowing water sample, it is possible to analyse up to 8 mL sample per minute with sufficient image quality to discriminate the invasive species Ostreopsis ovata from other particulates in samples taken directly from the Mediterranean. We also showcase the ability to achieve sharp images in flow-through at magnifications up to × 50.
Understanding the Externalizing Behavior of School-Age Boys: The Role of a Mother’s Mentalization and Attachment
Authors: Dejko–Wańczyk Karolina , Janusz Bernadetta , Józefik Barbara 
Published: September 2019

Abstract

Objectives
Externalizing behavior problems are considered to be a serious impediment to a child’s development, and therefore it is important to identify their predictors. In this study, we investigated the connections between school-aged boys’ externalizing problems, the mother’s reflective functioning (RF) and the mother’s perception of her childhood relationship with her own caregivers.

Methods
The study sample comprised 39 school-age boys diagnosed with externalizing behavior problems together with their mothers. A child’s psychopathology was assessed using the Child Behavior Checklist and Teacher Report Form. Our assessment of the mothers’ mentalizing capacities was based on the Adult Attachment Interview and Reflective Functioning Scale. The perception of a mother’s childhood relationship with her parents was assessed using the Parental Bonding Instrument.

Results
The analysis revealed that more severe cases of aggressive and rule-breaking behavior in boys were associated with lower RF in mothers, as well as with a mother’s perception of her childhood relationship with her own parents as less autonomous. More aggressive behavior in boys was also associated with a mother’s perception of herself as experiencing a higher degree of care from her father during her own childhood.

Conclusions
These are only preliminary findings and we have discussed them with a view to understanding the possible ways in which a mother’s RF and the intergenerational context of relationship quality are associated with externalizing behavior problems in middle childhood.
Quantifying the attractiveness of garden flowers for pollinators
Authors: Rollings Rosi , Goulson Dave 
Published: September 2019

Abstract
There is great interest in planting urban areas to benefit pollinating insects, with the potential that urban areas and gardens could act as an extensive network of pollinator-friendly habitats. However, there are a great many different plant cultivars available to the gardener, and a paucity of evidence-based advice as to which plants are truly most attractive to flower-visiting insects. Here, we report insect visitation to metre square plots of 111 different ornamental plant cultivars at a site in central UK. Data were collected over 5 years, and comprise over 9000 insect observations, which were identified to species (for honeybees and bumblebees) or as ‘solitary bees’, Syrphidae, Lepidoptera and ‘others’. Unlike some previous studies, we found no difference in numbers of insects attracted to native or non-native species, or according to whether plants were annuals, biennials or perennials, but we did find that native plants attracted a significantly higher diversity of flower-visiting insects. Overall, the most-visited plants were Calamintha nepeta, Helenium autumnale and Geranium rozanne. However, patterns of visitation were quite different for every insect taxa examined. For example, different species of short-tongued bumblebees showed little overlap in their most-preferred plant cultivars. Interestingly, very similar plant cultivars often attracted different insect communities; for example, 72% of visitors to Aster novi belgii were honeybees or bumblebees, while the related Anthemis tinctoria, which also has daisy-like flowers, did not attract a single honeybee or bumblebee but was popular with solitary bees, hoverflies, and ‘other’ pollinators. Some plant cultivars such as Eryngium planum and Myosotis arvensis were attractive to a broad range of insects, while others attracted only a few species but sometimes in large numbers, such as Veronicastrum virginicum and Helenium autumnale which were both visited predominantly by honey bees. It is clear that we do not yet fully understand what factors drive insect flower preferences. Recommendations are made as to which flower cultivars could be combined to provide forage for a diversity of pollinator groups over the season from early spring to autumn, though it must be born in mind that some plants are likely to perform differently when grown in different environmental conditions.
The Near-Miss Effect in Slot Machines: A Review and Experimental Analysis Over Half a Century Later
Authors: Pisklak Jeffrey M. , Yong Joshua J. H. , Spetch Marcia L. 
Published: September 2019

AbstractIn games of chance, a near miss is said to occur when feedback for a loss approximates a win. For instance, obtaining “cherry–cherry–lemon” on a slot machine could be considered a near miss. Sixty-six years ago, B.F. Skinner first proposed the idea that near-miss events might reinforce continued play in slot machines, and despite some inconsistencies in the experimental literature, belief in this “near-miss effect” has remained strong. In the present manuscript, we will review this literature and present experimental assessments of the near-miss effect on the frequency of the gambling response. Experiment 1 used a tightly controlled resistance-to-extinction procedure in pigeons to evaluate the putative reinforcing effect of near misses relative to a control “far-miss” reel pattern. Experiment 2 extended Experiment 1’s procedure to human participants. The results of both experiments failed to support the near-miss effect hypothesis. Experiment 3 used a further simplified procedure to assess the validity of the resistance-to-extinction paradigm when a probable conditional reinforcer was present on the reel stimuli. Although a clear conditional response was obtained from the reel, subsequent testing in extinction revealed no conditionally reinforcing function of this stimulus on operant response frequency.
Does catchment geodiversity foster stream biodiversity?
Authors: Kärnä Olli-Matti , Heino Jani , Laamanen Tiina , Jyrkänkallio-Mikkola Jenny , Pajunen Virpi , Soininen Janne , Tolonen Kimmo T. , Tukiainen Helena , Hjort Jan 
Published: September 2019

Abstract

Context
One approach to maintain the resilience of biotic communities is to protect the variability of abiotic characteristics of Earth’s surface, i.e. geodiversity. In terrestrial environments, the relationship between geodiversity and biodiversity is well recognized. In streams, the abiotic properties of upstream catchments influence stream communities, but the relationships between catchment geodiversity and aquatic biodiversity have not been previously tested.

Objectives
The aim was to compare the effects of local environmental and catchment variables on stream biodiversity. We specifically explored the usefulness of catchment geodiversity in explaining the species richness on stream macroinvertebrate, diatom and bacterial communities.

Methods
We used 3 geodiversity variables, 2 land use variables and 4 local habitat variables to examine species richness variation across 88 stream sites in western Finland. We used boosted regression trees to explore the effects of geodiversity and other variables on biodiversity.

Results
We detected a clear effect of catchment geodiversity on species richness, although the traditional local habitat and land use variables were the strongest predictors. Especially soil-type richness appeared as an important factor for species richness. While variables related to stream size were the most important for macroinvertebrate richness and partly for bacterial richness, the importance of water chemistry and land use for diatom richness was notable.

Conclusions
In addition to traditional environmental variables, geodiversity may affect species richness variation in streams, for example through changes in water chemistry. Geodiversity information could be used as a proxy for predicting stream species richness and offers a supplementary tool for conservation efforts.
Development of a novel patient-reported measure for acromegaly: the Acro-TSQ
Authors: Fleseriu Maria , Fogelfeld Leon , Gordon Murray B. , Sisco Jill , Colwell Hilary H. , Ludlam William H. , Haviv Asi , Mathias Susan D. 
Published: September 2019

Abstract

Purpose
Somatostatin analogs (SSAs) represent a mainstay of medical treatment for acromegaly, currently available as either intramuscular or deep subcutaneous injections. Patient-reported outcomes (PROs) are increasingly common as relevant outcomes in studies of acromegaly and its treatment, but there are no validated PRO measures available that focus on the disease burden and the impact of treatment, specifically designed for use in patients with acromegaly. We sought to develop a new and unique PRO measure, the Acromegaly Treatment Satisfaction Questionnaire (Acro-TSQ).

Methods
Concept elicitation (CE) interviews were conducted with acromegaly patients in the United States receiving SSA injections at a stable dose for ≥ 6 months. A questionnaire was drafted based on these interviews; combined CE and cognitive debriefing (CE/CD) interviews were then conducted to confirm the content, clarity, and relevance of the questionnaire.

Results
Nineteen subjects completed interviews [n = 9 CE, n = 10 CE/CD; n = 15 Lanreotide Depot/Autogel (Somatuline), n = 4 Octreotide LAR (Sandostatin LAR)]. Most subjects responded positively when asked about the effectiveness of their current treatment; however, breakthrough symptoms, injection site reactions, and side effects were commonly reported and had negative impacts on social and emotional well-being and daily activities. All 10 subjects involved in debriefing interviews found the questionnaire to be relevant, easy to complete, and found the response options to be clear. The resulting 26-item Acro-TSQ covers symptoms and symptom control, gastrointestinal side effects and their impact on daily activities, the emotional impact of treatment, convenience and ease of use, and overall satisfaction.

Conclusions
The Acro-TSQ is a novel PRO, focused on both disease burden and impact of treatment; it was found to be comprehensive, clear, and relevant for patients with acromegaly receiving injectable SSA treatment.
Dopamine agonist resistant prolactinomas: any alternative medical treatment?
Authors: Souteiro P. , Karavitaki N. 
Published: September 2019

Abstract
Consensus guidelines recommend dopamine agonists (DAs) as the mainstay treatment for prolactinomas. In most patients, DAs achieve tumor shrinkage and normoprolactinemia at well tolerated doses. However, primary or, less often, secondary resistance to DAs may be also encountered representing challenging clinical scenarios. This is particularly true for aggressive prolactinomas in which surgery and radiotherapy may not achieve tumor control. In these cases, alternative medical treatments have been considered but data on their efficacy should be interpreted within the constraints of publication bias and of lack of relevant clinical trials. The limited reports on somatostatin analogues have shown conflicting results, but cases with optimal outcomes have been documented. Data on estrogen modulators and metformin are scarce and their usefulness remains to be evaluated. In many aggressive lactotroph tumors, temozolomide has demonstrated optimal outcomes, whereas for other cytotoxic agents, tyrosine kinase inhibitors and for inhibitors of mammalian target of rapamycin (mTOR), higher quality evidence is needed. Finally, promising preliminary results from in vitro and animal reports need to be further assessed and, if appropriate, translated in human studies.
Software review: COCI, the OpenCitations Index of Crossref open DOI-to-DOI citations
Authors: Heibi Ivan , Peroni Silvio , Shotton David 
Published: September 2019

AbstractIn this paper, we present COCI, the OpenCitations Index of Crossref open DOI-to-DOI citations (http://opencitations.net/index/coci). COCI is the first open citation index created by OpenCitations, in which we have applied the concept of citations as first-class data entities, and it contains more than 445 million DOI-to-DOI citation links derived from the data available in Crossref. These citations are described using the resource description framework by means of the newly extended version of the OpenCitations Data Model (OCDM). We introduce the workflow we have developed for creating these data, and also show the additional services that facilitate the access to and querying of these data via different access points: a SPARQL endpoint, a REST API, bulk downloads, Web interfaces, and direct access to the citations via HTTP content negotiation. Finally, we present statistics regarding the use of COCI citation data, and we introduce several projects that have already started to use COCI data for different purposes.
The effect of collaborations on scientific research output: the case of nanoscience in Chinese regions
Authors: Scarazzati Stefano , Wang Lili 
Published: September 2019

AbstractThe pattern and impact of scientific collaborations depends on a country’s or region’s development stage. Prior to promoting scientific collaborations, it is crucial to understand what types of collaboration are more beneficial. By taking the stage of regional scientific development into consideration, this paper investigates the effect of various collaborations on regional scientific output. Our results highlight the differences between collaboration effects across regions at various capability levels. Scientifically weak regions benefit from more concentrated collaboration, in particular with advanced domestic regions. However, scientifically strong regions can benefit from a centrally located position in a broader collaboration network. Findings from this analysis indicate that international collaborations might not be beneficial a priori. Whether or not one region benefits from international collaborations depends on this region’s local capacity. Being embedded in a broad network structure can help increase one region’s publication output. However, such benefit is limited only to regions that have relatively higher research capacity.
The relationship between usage and citations in an open access mega-journal
Authors: McGillivray Barbara , Astell Mathias 
Published: September 2019

Abstract
How do the level of usage of an article, the timeframe of its usage and its subject area relate to the number of citations it accrues? This paper aims to answer this question through an observational study of usage and citation data collected about the multidisciplinary, open access mega-journal Scientific Reports. This observational study answers these questions using the following methods: an overlap analysis of most read and top-cited articles; Spearman correlation tests between total citation counts over two years and usage over various timeframes; a comparison of first months of citation for most read and all articles; a Wilcoxon test on the distribution of total citations of early cited articles and the distribution of total citations of all other articles. All analyses were performed in using the programming language R. As Scientific Reports is a multidisciplinary journal covering all natural and clinical sciences, we also looked at the differences across subjects. We found a moderate correlation between usage in the first year and citations in the first two years since publication (Spearman correlation coefficient of 0.49, α = 0.05), and that articles with high usage in the first six months are more likely to have their first citation earlier (Wilcoxon = 1,811,500, p < 0.0001), which is also related to higher citations in the first two years (Wilcoxon = 8,071,200, p < 0.0001). As this final assertion is inferred based on the results of the other elements of this paper, it would require further analysis.
Toward collaborative open data science in metabolomics using Jupyter Notebooks and cloud computing
Authors: Mendez Kevin M. , Pritchard Leighton , Reinke Stacey N. , Broadhurst David I. 
Published: September 2019

AbstractBackgroundA lack of transparency and reporting standards in the scientific community has led to increasing and widespread concerns relating to reproduction and integrity of results. As an omics science, which generates vast amounts of data and relies heavily on data science for deriving biological meaning, metabolomics is highly vulnerable to irreproducibility. The metabolomics community has made substantial efforts to align with FAIR data standards by promoting open data formats, data repositories, online spectral libraries, and metabolite databases. Open data analysis platforms also exist; however, they tend to be inflexible and rely on the user to adequately report their methods and results. To enable FAIR data science in metabolomics, methods and results need to be transparently disseminated in a manner that is rapid, reusable, and fully integrated with the published work. To ensure broad use within the community such a framework also needs to be inclusive and intuitive for both computational novices and experts alike.Aim of ReviewTo encourage metabolomics researchers from all backgrounds to take control of their own data science, mould it to their personal requirements, and enthusiastically share resources through open science.Key Scientific Concepts of ReviewThis tutorial introduces the concept of interactive web-based computational laboratory notebooks. The reader is guided through a set of experiential tutorials specifically targeted at metabolomics researchers, based around the Jupyter Notebook web application, GitHub data repository, and Binder cloud computing platform.
Seasonal influence of physicochemical parameters on phytoplankton diversity and assemblage pattern in Kailash Khal, a tropical wetland, Sundarbans, India
Authors: Gogoi Pranab , Sinha Archana , Das Sarkar Soma , Chanu Thangjam Nirupada , Yadav Anil Kumar , Koushlesh Satish Kumar , Borah Simanku , Das Sanjoy Kumar , Das Basanta Kumar 
Published: September 2019

AbstractStudies were carried out from April 2016 to March 2017 for effective understanding of diversity combined with environment-influenced spatiotemporal dynamics of microfloral structure inKailash Khalwetland of Indian Sundarbans. A total of 36 phytoplankton genera were recorded from the study area. Eight major algal groups were in order of: Bacillariophyceae > Cyanophyceae > Chlorophyceae > Coscinodiscophyceae > Xanthophyceae > Euglenophyceae > Conjugatophyceae > Mediophyceae with respect to their quantitative abundance. Mean seasonal abundance was found highest in pre-monsoon (4.32 × 103 cells l−1) followed by post-monsoon (3.88 × 103 cells l−1) and monsoon (1.96 × 103 cells l−1). One-way ANOVA showed that seasonal difference in physicochemical parameters was statistically significant for temperature, DO, specific conductivity, TA, TS, Ca++, nitrate, transparency, salinity, TH, turbidity, Mg++and phosphate (p < 0.05). pH, temperature, total hardness, TDS nitrate, phosphate and silicate showed a close affinity with the distribution of phytoplankton community as evident from canonical correspondence analysis. Margalef richness index (3.121–3.774) and Shannon–Wiener diversity index (2.730–2.939) indicated moderately rich phytoplankton diversity in the wetland ecosystem.
Assessment of Coxiella burnetii presence after tick bite in north-eastern Poland
Authors: Borawski Karol , Dunaj Justyna , Czupryna Piotr , Pancewicz Sławomir , Świerzbińska Renata , Żebrowska Agnieszka , Moniuszko-Malinowska Anna 
Published: September 2019

Abstract

Purpose
The aim of the study is to assess anti-Coxiella burnetii antibodies presence in inhabitants of north-eastern Poland, to assess the risk of Q fever after tick bite and to assess the percentage of co-infection with other pathogens.

Methods
The serological study included 164 foresters and farmers with a history of tick bite. The molecular study included 540 patients, hospitalized because of various symptoms after tick bite. The control group consisted of 20 honorary blood donors. Anti-Coxiella burnetii antibodies titers were determined by Coxiella burnetii (Q fever) Phase 1 IgG ELISA (DRG International Inc. USA). PCR was performed to detect DNA of C. burnetii, Borrelia burgdorferi and Anaplasma phagocytophilum.

Results
Anti-C. burnetii IgG was detected in six foresters (7.3%). All foresters with the anti-C. burnetii IgG presence were positive toward anti-B. burgdorferi IgG and anti-TBE (tick-borne encephalitis). Anti-C. burnetii IgG was detected in five farmers (6%). Four farmers with anti-C. burnetii IgG presence were positive toward anti-B. burgdorferi IgG and two with anti-TBE. Among them one was co-infected with B. burgdorferi and TBEV. Correlations between anti-C. burnetii IgG and anti-B. burgdorferi IgG presence and between anti-C. burnetii IgG presence and symptoms of Lyme disease were observed. C. burnetii DNA was not detected in any of the 540 (0%) patients.

Conclusions
C. burnetii is rarely transmitted by ticks, but we proved that it is present in the environment, so it may be a danger to humans. The most common co-occurrence after tick bite concerns C. burnetii and B. burgdorferi.