bluuebunny/crossref_metadata_2025_split huggingface dataset:
From fertilizer to refuse: the history of human waste disposal in Shanghai, 1949–2010
Authors: Wang Gang 
Published: December 2024

Abstract
As the most populous city in China, Shanghai’s human waste disposal underwent a dramatic transition between 1949 and 2010. While human waste continued to be sold to farmers as fertilizer, the authorities attempted to modernize the methods of manual removal, promoting nightsoil dump stations and vacuum trucks from the early 1970s. These new methods soon became widespread. However, urban human waste gradually lost its value as fertilizer from the late 1970s, chiefly because of the popularization of chemical fertilizers, at which point Shanghai was faced with serious human waste issues. Encountering this unforeseen shift, the municipality had to accept the reality that there were no longer rural markets for urban human waste, and that it would have to start treating human waste as refuse. In contrast to the Western model, Shanghai’s approach to modernizing human waste disposal was distinctive, having been influenced by factors beyond the city.
The co-design of support strategies for sustainable, healthy and affordable food provision in Early Childhood Education settings
Authors: Elford Audrey , Spence Alison C , Campbell Karen J , Rozman Margaret , Love Penelope 
Published: December 2024

Abstract

Objective:
To co-design support strategies to enable sustainable, healthy, affordable food provision, including waste mitigation practices, in Australian Early Childhood Education and Care (ECEC) settings.

Design:
Based on the co-design IDEAS framework (Ideate, DEsign, Assess & Share), this co-design process involved iterative interviews and focus groups with ECEC centre staff and workshops with Nutrition Australia. Interview and workshop themes were coded to the Theoretical Domains Framework (TDF) to develop initial prototypes for support strategies that were further developed and refined in focus groups.

Setting:
ECEC with onsite food provision, in Victoria, Australia.

Participants:
ECEC staff and a Victorian Government-funded programme delivered through Nutrition Australia that provides nutrition support to ECEC services.

Results:
ECEC staff interviews (n 17) suggested a lack of knowledge on the topic of sustainable healthy food provision and a need for resources and support for all staff and children. Workshops with Nutrition Australia built on interviews and suggested a focus on lower intensity strategies and a suggestion to embed knowledge-related activities into the children’s curriculum. Focus groups (n 8) further informed co-design of strategies, producing a visual representation of sustainable healthy food provision with supporting tips and a whole-of-centre approach that includes children through a classroom activity.

Conclusions:
The co-designed resources could provide feasible strategies for the adoption of sustainable, healthy and affordable provision practices in the ECEC setting. Involvement of a local government-funded health promotion service provides valuable research-to-practice contribution as well opportunity for scalable dissemination of resources through existing infrastructure.
Jupiter's Whistler‐Mode Belts and Electron Slot Region
Authors: Hao Y.‐X. , Shprits Y. Y. , Menietti J. D. , Liu Z. Y. , Averkamp T. , Wang D. D. , Kollmann P. , Hospodarsky G. B. , Drozdov A. , Roussos E. , Krupp N. , Horne R. B. , Woodfield E. E. , Bolton S. J. 
Published: December 2024

AbstractThe spatial distribution of whistler‐mode wave emissions in the Jovian magnetosphere measured during the first 45 perijove orbits of Juno is investigated. A double‐belt structure in whistler‐mode wave intensity is revealed. Between the two whistler‐mode belts, there exists a region devoid of 100 s keV electrons near the magnetic equator at . Insufficient source electron population in such an electron “slot” region is a possible explanation for the relatively lower wave activity compared to the whistler‐mode belts. The wave intensity of the outer whistler‐mode belt measured in the dusk‐premidnight sector is significantly stronger than in the postmidnight‐dawn sector. We suggest that the inherent dawn‐dusk asymmetries in source electron distribution and/or auroral hiss emission rather than the modulation of solar cycle are more likely to result in the azimuthal variation of outer whistler‐mode belt intensity during the first 45 Juno perijove orbits.
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Authors: Froese Jordan T. , Balsamo Joseph A. , Reisman Benjamin J. , Barone Sierra M. , Irish Jonathan M. , Bachmann Brian O. 
Published: December 2024

Abstract
Chemical and biological stimulus screening in a hypogean actinomycete was used to elicit secondary metabolism. Optimal biosynthesis of bioactive natural products was identified using Multiplexed Activity Profiling for determining dose-dependent activity via six single-cell biological readouts. Bioactive extracts were fractioned to establish candidate compounds for isolation using Multiplexed Activity Metabolomics by correlating microtiter well-isolated phenotypes and extracted ion current peaks. This guided the isolation of four filipin polyene macrolides including a new metabolite filipin XV, an alkyl side-chain hydroxylated congener of the filipin chainin, with substantially attenuated cytotoxicity. Filipin-specific cytotoxicity was confirmed using flow cytometry and fluorescence microscopy.
Blood pressure measurement and nocturnal dipping patterns are heavily affected by body posture through changes in hydrostatic pressure between the arm and the heart
Authors: Pilz Niklas , Narkiewicz Krzysztof , Wolf Jacek , Kario Kazuomi , Visser Tinta , Opatz Oliver S. , Reuter Alma , Dippel Laura J. , Fesseler Leon , Heinz Viktor , Patzak Andreas , Bothe Tomas L. 
Published: December 2024

AbstractNocturnal blood pressure (BP) shows the highest predictive power for cardiovascular events. However, there is a poor reproducibility of personalized dipping patterns in single individuals. We hypothesize that changes in body position during sleep cause variations in hydrostatic pressure,leading to incorrect BP values and dipping classifications. 26 subjects aged 18–30 years, as well as 25 participants aged 50 years and older underwent ambulatory BP measurements on the left arm, as well as determination of the hydrostatic pressure difference between the cuff and heart level during BP measurement. We observed that the BP measurement cuff was above the heart level (negative hydrostatic pressure) mostly through the night. Laying on the right side revealed the largest hydrostatic pressure difference and maximum incorrect BP measurement, with a mean of –9.61 mmHg during sleep. Correcting for hydrostatic pressure led to reclassification of nocturnal hypertension in 14 subjects (27.5%). Dipping patterns changed in 19 participants (37.3%). In total, 25 subjects (49.0%) changed either their nocturnal hypertension and/or their dipping classification. Our findings underscore the importance of accounting for hydrostatic pressure in ambulatory BP monitoring. Changes in body posture during sleep provide a plausible reason for the variability seen in nocturnal dipping patterns. Further research should focus on incorporating hydrostatic pressure compensation mechanisms in 24-h BP measurement. Limiting the noticeable effect of hydrostatic pressure differences could greatly improve hypertension diagnosis, classification, and treatment monitoring.
Compass-model physics on the hyperhoneycomb lattice in the extreme spin-orbit regime
Authors: Okuma Ryutaro , MacFarquharson Kylie , Johnson Roger D. , Voneshen David , Manuel Pascal , Coldea Radu 
Published: December 2024

AbstractThe physics of spin-orbit entangled magnetic moments of 4d and 5d transition metal ions on a honeycomb lattice has been much explored in the search for unconventional magnetic orders or quantum spin liquids expected for compass spin models, where different bonds in the lattice favour different orientations for the magnetic moments. Realising such physics with rare-earth ions is a promising route to achieve exotic ground states in the extreme spin-orbit limit; however, this regime has remained experimentally largely unexplored due to major challenges in materials synthesis. Here we report the successful synthesis of powders and single crystals of β-Na2PrO3, with 4f1 Pr4+ jeff = 1/2 magnetic moments arranged on a hyperhoneycomb lattice with the same threefold coordination as the planar honeycomb. We find a strongly non-collinear magnetic order with highly dispersive gapped excitations that we argue arise from frustration between bond-dependent, anisotropic off-diagonal exchanges, a compass quantum spin model not explored experimentally so far. Our results show that rare-earth ions on threefold coordinated lattices offer a platform for the exploration of quantum compass spin models in the extreme spin-orbit regime, with qualitatively distinct physics from that of 4d and 5d Kitaev materials.
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Authors: Valerie Nicholas C. K. , Sanjiv Kumar , Mortusewicz Oliver , Zhang Si Min , Alam Seher , Pires Maria J. , Stigsdotter Hannah , Rasti Azita , Langelier Marie-France , Rehling Daniel , Throup Adam , Purewal-Sidhu Oryn , Desroses Matthieu , Onireti Jacob , Wakchaure Prasad , Almlöf Ingrid , Boström Johan , Bevc Luka , Benzi Giorgia , Stenmark Pål , Pascal John M. , Helleday Thomas , Page Brent D. G. , Altun Mikael 
Published: December 2024

AbstractCellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as a platform that can concomitantly evaluate drug-target interactions and phenotypic responses using conditionally stabilized drug biosensors. We observe that drug-responsive proteotypes are prevalent among reported mutants of known drug targets. Compatible mutants appear to follow structural and biophysical logic that permits intra-protein and paralogous expansion of the biosensor pool. We then apply our method to uncouple target engagement from divergent cellular activities of MutT homolog 1 (MTH1) inhibitors, dissect Nudix hydrolase 15 (NUDT15)-associated thiopurine metabolism with the R139C pharmacogenetic variant, and profile the dynamics of poly(ADP-ribose) polymerase 1/2 (PARP1/2) binding and DNA trapping by PARP inhibitors (PARPi). Further, PARP1-derived biosensors facilitated high-throughput screening for PARP1 binders, as well as multimodal ex vivo analysis and non-invasive tracking of PARPi binding in live animals. This approach can facilitate holistic assessment of drug-target engagement by bridging drug binding events and their biological consequences.
Kalman contrastive unsupervised representation learning
Authors: Jahani Yekta Mohammad Mahdi 
Published: December 2024

AbstractWe first propose a Kalman contrastive (KalCo) framework for unsupervised representation learning by dictionary lookup. It builds a dynamic dictionary of encoded representation keys with a queue and a Kalman filter encoder, to which the encoded queries are matched. The large and consistent dictionaries built this way increase the accuracy of KalCo to values much higher than those of the famous momentum contrastive (MoCo) unsupervised learning, which is actually a very simplified version of KalCo with only a fixed scaler momentum coefficient. For a standard pretext task of instance discrimination on the ImageNet-1M (IN-1M) dataset; e.g., KalCo yields an accuracy of 80%, compared to 55% for MoCo. Similar results are obtained also on Instagram-1B (IG–1B). For the same task on a bunch of OpenfMRI datasets, the accuracy is 84%. We then upgrade KalCo to KalCo v2 by using an MLP projection head and more data augmentation, along also with a larger memory bank. The accuracy of KalCo v2 is around the even more impressive amounts of 90% on IN-1M and IG-1B, and 95% on OpenfMRI, the first being about 3% higher than those of three most-cited recent alternatives.
Karma economies for sustainable urban mobility – a fair approach to public good value pricing
Authors: Riehl Kevin , Kouvelas Anastasios , Makridis Michail A. 
Published: December 2024

AbstractCity road infrastructure can be considered a public good, and congestion is the intersection of demand for mobility with the limited available transportation supply. Congestion pricing is effective in reducing demand to sustainable levels below network capacity limits, but also controversial, as it introduces equity issues and systematically discriminates against lower-income groups. Karma is a non-monetary, fair, and efficient resource allocation mechanism that employs an artificial currency different from money, incentivises cooperation amongst selfish individuals, and achieves a balance between giving and taking. Where money does not do its job, Karma achieves socially more desirable allocations by being aligned with consumers’ needs rather than their financial power. This work highlights the value proposition of Karma, provides guidance on Karma mechanism design, and equips the reader with a useful software framework to model Karma economies and predict consumers’ behaviour. A case study of road pricing demonstrates Karma’s potential.
Angeborene Dakryozystozelen bei Säuglingen – Langzeitergebnisse nach minimalinvasiver endoskopischer endonasaler Therapie
Authors: Stähr Kerstin , Eckstein Anja , Neumann Inga , Hussain Timon , Lang Stephan , Mattheis Stefan 
Published: December 2024

Zusammenfassung
Einleitung Kongenitale Dakryozystozelen sind selten und werden durch eine Obstruktion des Tränen-Nasen-Ganges bedingt. Symptomatisch zeigen sich Epiphora, Nasenatmungsbehinderung und eine Schwellung des medialen Kanthus. Therapeutisch erfolgt zumeist eine Eröffnung der Hasner-Klappe durch Sondierung und ggf. Intubation der Tränenwege. Wir stellen ein minimalinvasives endoskopisches Vorgehen mit Marsupialisation des endonasalen Zelenanteils vor. Auf eine zusätzliche Manipulation im Bereich des Tränenweges wird zur Vermeidung von iatrogenen Verletzungen verzichtet.
Methoden Insgesamt konnten 19 Kinder (21 Augen) im Alter von 3 Tagen bis 39 Monaten in die retrospektive Auswertung eingeschlossen werden. Zwei der Patienten litten an akuter Atemnot, 7 Kinder unter rezidivierenden Infektionen mit persistierender Epiphora und 12 hatten eine akute Dakryozystitis mit orbitaler Phlegmone.
Ergebnisse In allen Fällen konnte ein endonasaler Zelenanteil detektiert und endoskopisch endonasal reseziert werden. Bei 2 Kindern, die primär im Alter von 22 und 39 Monaten operiert wurden, kam es zu Rezidiven, was jeweils eine Revisionsoperation per Dakryozystorhinostomie erforderlich machte. Alle übrigen 17 Kinder waren rezidivfrei.
Zusammenfassung Unsere Ergebnisse zeigen, dass eine endoskopische endonasale Marsupialisation ohne zusätzliche Intubation oder Sondierung der Tränenwege ein erfolgreiches Therapieregime für konnatale Dakryozystozelen darstellt. Iatrogen bedingte Vernarbungen, die Anlage einer Via falsa oder eine postoperative Bakteriämie können so vermieden werden. Bei älteren Kindern mit stattgehabten Entzündungen in der Vorgeschichte, sinkt die Erfolgsrate der hier vorgestellten Operationstechnik.
Innovative Option bei gastrointestinalen Tumoren
Authors: Arnheim Katharina 
Published: December 2024

ZusammenfassungZahlreiche Sitzungen auf dem Kongress der European Society of Medical Oncology (ESMO) beschäftigten sich
mit neuen Therapiestrategien bei den verschiedenen Tumoren des Gastrointestinaltrakts. Eine kleine
Auswahl wird im Folgenden vorgestellt.
Traumatisch bedingte Subluxation der Halswirbelsäule bei einer
einjährigen Alpakastute
Authors: Hümmelchen Hannah , Petzold Jana , Wagner Henrik 
Published: December 2024

ZusammenfassungEine einjährige Alpakastute wurde aufgrund einer seit 2 Wochen bestehenden
seitlichen Krümmung der oberen Halswirbelsäule vorstellig. Aufgrund des
Vorberichtes wurde von einer traumatischen Einwirkung ausgegangen. Futter- und
Tränkeaufnahme waren uneingeschränkt, das Gangbild war durch geringgradig
ataktische Bewegungen an allen 4 Gliedmaßen auffällig. Das Tier zeigte bei
Erstvorstellung keine weiteren neurologischen Ausfallserscheinungen.
Röntgenologisch stellte sich eine Verschiebung der Halswirbel nach links im
Rahmen einer Subluxation der Gelenkfortsätze der Halswirbel C4 und C5 dar. Im
Verlauf der konservativen Therapie mittels Schmerzmedikation kamen neurologische
Symptome wie Ataxie und Gleichgewichtsstörung bei uneingeschränkter
Nahrungsaufnahme hinzu. Das Tier verendete unbeobachtet.In der pathologischen Untersuchung konnten auf Höhe der Achsabweichung der
Halswirbelsäule im Halsmark degenerative und entzündliche Veränderungen sowie
Blutungen festgestellt werden. Im Zusammenhang mit dem Vorbericht sind die
Befunde am ehesten als Folge eines stumpfen Traumas zu sehen und Ursache für die
neurologischen Symptome.Dies ist der erste weitergehend aufbereitete Fall einer Subluxation der
Halswirbelsäule bei einem Alpaka in Deutschland.
Präputialspülung vor dem Deckakt, sinnvoll oder
nicht?
Authors: Kühn Katharina , Meyer-Lindenberg Andrea , Reese Sven , Wolf Georg , Walter Beate , Leykam Christian , Flock Ulrike , Otzdorff Christiane 
Published: December 2024

Zusammenfassung
Gegenstand und Ziel Im Präputium des Rüden können verschiedene fakultativ
pathogene Bakterien nachgewiesen werden. Um diese zu reduzieren, spülen einige
Züchter/-innen das Präputium ihrer Deckrüden vor dem Deckakt. Ziel dieser Studie
ist es, herauszufinden, ob Präputialspülungen vor dem Deckakt medizinisch
sinnvoll sind.
Material und Methoden Bei 20 Rüden wurde das Präputium mit physiologischer
Kochsalzlösung und im Abstand von mindestens 4 Wochen mit Caniprevent gespült.
Der Effekt der unterschiedlichen Spüllösungen wurde mittels mikrobiologischer
Untersuchungen von Tupferproben, die vor und nach der Spülung genommen wurden,
verglichen.
Ergebnisse Am häufigsten wurden Escherichia coli, Staphylococcus
pseudintermedius, Streptococcus canis und Mykoplasmen identifiziert. Es
konnte kein signifikanter Unterschied in der Anzahl der nachgewiesenen Bakterien
bei Hunden mit und ohne Präputialkatarrh (p=0,878) ermittelt werden. Nach den
Spülungen kam es zu einer signifikanten Abnahme des Bakterienwachstums, wobei
die Bakterienreduktion nach Präputialspülung mit Caniprevent mit 20,8%
(p<0,001) ausgeprägter war als nach einer Spülung mit NaCl (p=0,004).
Schlussfolgerung Obwohl in dieser Studie eine Reduktion von Bakterien
durch Präputialspülungen nachgewiesen wurde, können medizinische Vorteile einer
prophylaktischen Spülung derzeit noch nicht eingeschätzt werden.
Klinische Relevanz Im Hinblick auf den Präputialkatarrh und
Präputialspüllösungen gibt es weiteren Forschungsbedarf, um die
Tierhalter/-innen besser aufklären und beraten zu können.
Vergleich der kurzfristigen und 3-jährigen onkologischen Ergebnisse zwischen roboterassistierter und laparoskopischer Gastrektomie bei Magenkarzinom
Authors: Manekeller Steffen 
Published: December 2024

ZusammenfassungZiel der vorliegenden Arbeit war es, die kurzfristigen und langfristigen Ergebnisse zwischen roboterassistierter Gastrektomie und laparoskopischer Gastrektomie bei Patienten mit Magenkarzinom zu vergleichen.
Biomarker für die Car-T-Zelltherapie
Authors: Krome Susanne 
Published: December 2024

ZusammenfassungCD19-gerichtete CAR-T-Zellen können bei rezidivierten und refraktären großzelligen B-Zell-Lymphomen (R/R LBCL) dauerhafte Remissionen induzieren, aber 60 % der Erkrankten sprechen nicht auf die Behandlung an oder bekommen einen Rückfall. In Anbetracht der Belastung und des Aufwandes sind Prädiktoren für das Therapieansprechen dringend notwendig, so die italienische Studiengruppe. Carniti et al. identifizierten genetische und Apheresekomponenten, die den Therapieerfolg vorhersagten.
A Rare Case of Dual Primary Supratentorial Glioma and Infratentorial Meningioma
Authors: Yip Chi-Man , Jan Chia Ing 
Published: December 2024

Abstract
Introduction Gliomas and meningiomas are two common primary brain tumors, but occurring simultaneously in the same patient is a rare entity. The authors would like to report a case of coexistence of a superior parietal lobule diffuse glioma, IDH-wild type, histologically CNS WHO grade 3 and a left posterior fossa transitional meningioma, WHO grade 1; both the tumors were successfully removed in one-stage operation.
Case Presentation A 68-year-old female having hypertension, who presented to us with the chief complaints of involuntary shaking of her left lower limb associated with her left upper limb tingle, dizziness, and neck soreness. She was found to have a lesion in her right parietal region and a tumor in her left cerebellar region. After detailed discussion with the patient and thorough preoperative evaluation, the authors performed a right parietal craniotomy and a left retrosigmoid approach in one-stage operation to remove both the tumors, which were proven to be of two distinct histological identities.
Conclusion The management for two tumors located far apart needs a case-by-case evaluation. An important aspect while dealing with such cases is to decide which tumor needs to be operated first or whether both lesions can be operated at the same time with one-stage operation.
Application of comprehensive nursing combined with ISBAR handover
approach in the nursing of patients with placental abruption
Authors: Yang Qing , Liu Ningning , Xie Wanyang 
Published: December 2024

Abstract
Objective  The research for this paper was conducted to unveil the effect
of comprehensive nursing combined with the
Identification-Situation-Background-Assessment-Recommendation (ISBAR) handover
approach in the nursing of patients with placental abruption.
Methods  The 40 cases of placental abruption patients admitted to the
Women’s Hospital School of Medicine Zhejiang University from May 2021 to May
2022 were subjected to conventional basic nursing combined with traditional
handover tool intervention, which was recorded as the control group; the 40
cases of placental abruption patients admitted to the Women’s Hospital School of
Medicine Zhejiang University from June 2022 to June 2023 were subjected to
comprehensive nursing combined with ISBAR handover tool intervention, which was
recorded as the observation group. Maternal and infant outcomes, the quality of
nurse handover, and the psychological burden [State Anxiety Inventory (S-AI),
Trait Anxiety Inventory (T-AI), Distress Thermometer (DT), and General
Self-Efficacy Scale (GSES)] were observed in the two groups, and the
satisfaction with nursing was also assessed by using a self-administered
satisfaction scale in the two groups.
Results  The rate of normal delivery of patients in the observation group
was higher and the rate of cesarean section and the total incidence of
complications were lower than that of the control group. The 1- and 5-min Apgar
scores of the newborns in the observation group were higher and the total
complication rate was lower than that in the control group. Nurses in the
observation group had higher scores for nursesʼ shift handover quality. S-AI,
T-AI, and DT scores were lower in both groups after the intervention and were
lowest in the observation group; GSES scores were higher and were highest in the
observation group. Satisfaction with nursing was higher in the observation group
than in the control group.
Conclusion  Comprehensive nursing combined with the ISBAR handover
approach applied to the clinical care of patients with placenta abruption can
effectively improve the outcomes of mothers and infants, enhance the quality of
nursesʼ shift handovers, reduce the psychological burden of patients and
increase nursing satisfaction.