bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Screen Time with its Effect on Health among Secondary School Students
Authors: Rahman Md Sohanur , Roy Biplab Kumar , Nazneen Nazia , Molla Md Shahin , Suvo Sohanur Rahman 
Published: November 2024

Background: Secondary school students are more and more immersed in a world dominated by screens in the modern digital era. Screens, ranging from laptops to tablets, televisions to smartphones, have embedded themselves into daily life and significantly impact how youngsters communicate, learn, and pass the time.
Objective: The study's objective was to find out the assessment of screen time and its effect on health among rural secondary school students in Bangladesh.
Methods: This cross-sectional descriptive type of study was carried out in Govt. Jalma Chakrakhali Secondary School in Batiaghata Upazilla under Khulna district. A total of 460 students were selected using a convenient sampling technique from a selected school in Khulna district. Face-to-face interviews with a semi-structured questionnaire were used to collect data. Data were analyzed following the study's objectives. Before data collection, informed consent was taken, and ethical concerns were addressed at different stages of the study.
Results: Among 460 respondents, a large number 52% (241) were between 14-16 years of age group. Only 38% had a personal mobile phone, while where a maximum (72%) used their parents' phones. Male students (76%) had a greater tendency to operate mobile phones in comparison to females (64%). Among the parents, most of them (82%) had a smartphone. Most of the respondents [395 (86%)] had a TV at their house and 304 (66%) watched TV regularly. Almost half of the respondents [223(48%)] suffered from various health issues, where headaches and blurring of vision were the main features.
Conclusion: This study painted a clear picture of the effect of screen time on Bangladeshi rural school-going youngsters, and it may be able to assist the relevant authorities in developing policies and formulating plans to address the issue.
Mediscope 2024;11(2): 82-86
Pendampingan Belajar Siswa Speech Delay di RA Hidayatus Shibyan Senori Tuban
Authors: Fitrianingsih Eka Nurul , Fitri Nur Lailatul , Novitasari Nurul 
Published: November 2024

This study aims to find out the form of learning assistance for speech delay students at RA Hidayatus Shibyan and find out the obstacles experienced by teachers when teaching speech delay students. Language development is very important for every child because language aims to facilitate communication and express the feelings of early childhood. The research method used was descriptive qualitative, with the research subject being a student who experienced speech delay, 1 class teacher, and 1 accompanying teacher. Data collection techniques through observation, interviews, and documentation. The results of this study are 1) learning assistance for children who experience speech delay is carried out using a floor time approach and through learning methods, 2) while the obstacles experienced by teachers are that students often make mistakes or forget the pronunciation they have learned before, and lack of support and stimulation provided by parents at home
Between compounding and phrasal derivation: Polish complex nouns in sam(o)-
Authors: Kolbusz-Buda Joanna 
Published: November 2024

The aim of this paper is to explore the class of Polish complex nouns with the initial combining form samo-, such as samobójca ‘suicide’. The study seeks to determine the morphological structure of what we consider to be a case of ‘syntax-inside-morphology’ in the domain of Polish word-formation. We want to argue that what appears to be sheer concatenation of morphological building blocks, often routinely classified as a compound word with a lefthand bound root, could, in fact, be interpreted as a derived noun based on a phrasal unit. In what follows, we shall argue that the morphosemantics of Polish complex nouns in samo- can successfully be captured by left-branching structure, which ensures that their morphological and semantic representations cohere into a well-organised whole. The dispute over derivational phenomena exhibiting a degree of reciprocity between morphology and syntax has long surrounded the data-driven examination of certain word-formation types across languages. Currently, a rich body of linguistic data amassed across various languages seems to strongly undermine the aprioristic separation of the two modules of grammar. The present study draws on tenets central to theories which are neither strictly lexicalist nor syntactocentric, in particular the Firewall Theory advanced by Lieber & Scalise (2006) .
The Effect of Combined Foot Massage and Nature Music on the Sleep Quality of Critically Ill Patients
Authors: Nurhayati Nunung , Waluyo Agung , Kariasa I Made , Asih Sali Rahadi 
Published: November 2024

Aims: Critical patients in ICU and HCU often experience poor sleep due to excessive stress and various symptoms like environmental factors, pain, noise, anxiety, and physical discomfort. Foot massage and natural music interventions can help meet their sleep needs, providing a relaxing effect and improving physical and psychological conditions. The purpose of this study is to determine the effect of providing combination therapy of foot massage and natural music therapy in Dr. Hospital's peacock room Salamun 2023.
Methods: This type of research is pre-experimental with a pre-post test of one group and uses the Richard Champbell Sleep Questionnaire (RCSQ). Then the data was processed using a paired sample T-test. The sample in this study is 16 respondents.
Results: The results of the statistical test obtained a p-value of 0.01, meaning that there was an effect between the pretest and posttest of the combination of foot massage and natural music therapy on the quality of sleep in critical patients in the peacock room at Dr. Salamun Hospital, Bandung City, 2023.
Conclusions : the conclusion of this study is that there is an effect of foot massage therapy and natural music on the sleep quality of critical patients as shown by the results of measuring the quality of critical patients before and after consecutive interventions with massage of both feet combined with natural music. For 10 minutes it has been proven to be able to improve sleep quality in critically ill patients so that this intervention can be applied as a therapy to improve sleep quality.
Strain-level genomic analysis of serotype, genotype and virulence gene composition of group B streptococcus
Authors: Zeng Zhen , Li Meng , Zhu Simin , Zhang Ke , Wu Yifan , Zheng Minzi , Cao Yang , Huang Zhenyu , Liao Qinping , Zhang Lei 
Published: November 2024

IntroductionGBS (group B streptococcus) is an opportunistic pathogen that can colonize healthy individuals but presents significant challenges in clinical obstetrics and gynecology, as it can cause miscarriage, preterm birth, and invasive infections in newborns. To develop specific and personalized preventative strategies, a better understanding of the epidemiological characteristics and pathogenic features of GBS is essential.MethodsWe conducted a comprehensive strain-level genomic analysis of GBS, examining serotype and genotype distributions, as well as the composition and correlations of virulence genes using the blastn-short mode of the BLAST program(v2.10.0+), mlstsoftware (https://github.com/tseemann/mlst), Snippy (v4.6.0), FastTree (v2.1.11) and iTOL. The coding sequence region of virulence factors was annotated by Prodigal (v2.6.3) and Glimmer(v3.02b). We further identified host protein interacting with Srr2 by mass spectrometry analysis.ResultsWhile certain genotypes showed strong serotype consistency, there was no significant association between overall serotypes and genotypes. However, the composition of virulence genes was more closely related to the phylogeny of GBS, among which simultaneous presence of Srr2 and HygA exhibit significant association with hypervirulence. Tubulin emerged as the most distinct and abundant hit. The specific interaction of Tubulin with Srr2-BR, rather than Srr1-BR, was further confirmed by immunoblotting.DiscussionConsidering the impact of cytoskeleton rearrangement on GBS pathogenesis, this observation offers a plausible explanation for the hypervirulence triggered by Srr2. Collectively, our findings indicate that in the future clinical practice, virulence gene detection should be given more attention to achieve precise GBS surveillance and disease prevention.
Data management practice of health extension workers and associated factors in Central Gondar Zone, northwest Ethiopia
Authors: Melaku Mequannent Sharew , Yohannes Lamrot 
Published: November 2024

IntroductionGenerating quality data for decision-making at all levels of a health system is a global imperative. The assessment of the Ethiopian National Health Information System revealed that health information system resources, data management, dissemination, and their use were rated as “not adequate” among the six major components of the health system. Health extension workers are the frontline health workforce where baseline health data are generated in the Ethiopian health system. However, the data collected, compiled, and reported by health extension workers are unreliable and of low quality. Despite huge problems in data management practices, there is a lack of sound evidence on how to overcome these health data management challenges, particularly among health extension workers. Thus, this study aimed to assess data management practices and their associated factors among health extension workers in the Central Gondar Zone.MethodAn institution-based cross-sectional study was conducted among 383 health extension workers. A simple random sampling method was used to select districts, all health extension workers were surveyed in the selected districts, and a structured self-administered questionnaire was used for data collection. The data was entered using EpiData version 4.6 and analyzed using STATA, version 16. Bivariable and multivariable binary logistic regression analyses were executed. An odds ratio with a 95% confidence interval and a p-value of &lt;0.05 was calculated to determine the strength of the association and to evaluate statistical significance, respectively.ResultsOf the 383 health extension workers enrolled, all responded to the questionnaire with a response rate of 100%. Furthermore, 54.7% of the respondents had good data management practices. In the multivariable logistic regression analysis, being a married woman, having good data management knowledge, having a good attitude toward data management, having 1–5 years of working experience, and having a salary ranging from 5,358 to 8,013 Ethiopian Birr were the factors significantly associated with good data management practices among health extension workers. The overall data management practice was poor with only five health extension workers out of ten having good data management practices.
Internal adaptation assessment of implant infrastructures manufactured through five different techniques (heat-press, milling, lost wax, calcinable cylinder, and CAD/Waxx®): an in vitro pilot study
Authors: Sartori Régis , Fernandes Juliana Campos Hasse , Fernandes Gustavo Vicentis Oliveira , Joly Julio Cesar 
Published: November 2024

IntroductionThe aim of this study was to evaluate the fit performance of implant infrastructures manufactured by five different techniques: heat-press (IPS), milling (ZIR), lost wax (CER), calcinable cylinder (CAL), and CAD/Waxx® (CAD).MethodsThe methodology was based on the Replica Technique, which can simulate and evaluate the fit of the infrastructure on the implant component. Thus, each infrastructure was internally filled with low-viscosity silicone addition and seated on the component until its final setting, obtaining the replica of the cementation space. After removing the coping containing the silicone film, light-density silicone was inserted addition in place of the components, and in its surroundings, condensation silicone was applied, establishing support for the assembly. The joint was sectioned mesiodistally, photographed, and analyzed in image processing software in order to measure the thickness of the interface infrastructure/implant at five different areas: marginal opening (M), gingival-axial angle (G-A), axial region (A), axial-occlusal angle (A-O) and occlusal surface (O).ResultsThe lowest and the highest average thickness between groups was, respectively, IPS: 187.5 μm and CAD: 221.6 μm, with statistically significant differences (p &lt; 0.01) among all five groups; the lowest and the highest average of all groups in each point was, respectively, A: 99.86 μm and O: 279.78 μm. The IPS group exhibited the lowest value of the internal space of the infrastructure on the implant. The marginal region of all groups demonstrated a correlation with the findings in the literature, except the CAL group; otherwise, the occlusal region and the angles A-O and G-A exhibited values beyond that expected.DiscussionIt was possible to conclude that the five infrastructure groups presented different adaptations, suggesting possible interference in the internal spaces due to the manufacturing infrastructure processes.
Efficacy of acupuncture for lumbar disc herniation: changes in paravertebral muscle and fat infiltration – a multicenter retrospective cohort study
Authors: Yan Liang , Zhang Jiliang , Wang Xianliang , Zhou Qinming , Wen Jingdong , Zhao Haihong , Guo Kai , Zeng Jianhua 
Published: November 2024

ObjectiveThis study seeks to elucidate the dynamic alterations in the multifidus, erector spinae, and psoas major muscles, along with their fatty infiltration, in patients diagnosed with lumbar disc herniation treated through acupuncture. Concurrently, the Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores are employed to evaluate modifications in lumbar and leg pain and the enhancement in lumbar functionality.MethodsA retrospective multi-center cohort study enrolled 332 adult LDH patients. Participants were divided into acupuncture and rehabilitation therapy groups. The acupuncture cohort received targeted treatments at specific acupuncture points, while the rehabilitation group received traditional rehabilitative therapy. Magnetic Resonance Imaging (MRI) gauged muscle cross-sectional areas (Sm, Se, Sp) and their ratios to vertebral area (Sm/Sv, Se/Sv, Sp/Sv), and fatty infiltration areas (Sfm, Sfe, Sfp) and their ratios (Sfm/Sv, Sfe/Sv, Sfp/Sv). Pain and function were assessed using Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores pre-treatment, 2-weeks, and 3-months post-intervention.ResultsA total of 332 patients were enrolled for analysis. Post-treatment, the acupuncture group exhibited increased Sm, Se, Sp and their ratios and reduced fatty infiltration areas and their ratios (P&lt;0.05) compared to rehabilitation. Both treatments decreased VAS scores and enhanced JOA scores at both intervals (P&lt;0.05). Intriguingly, no significant disparities were observed between the acupuncture and rehabilitation groups concerning pain and JOA scores at the 2-week follow-up (p&gt;0.05); however, 3 months post-treatment, the acupuncture group significantly outperformed the rehabilitation group in both pain and JOA scores (p&lt;0.05).ConclusionThis study demonstrates that acupuncture treatment is significantly more effective than traditional rehabilitation therapy in improving paraspinal muscle function, reducing muscle fat infiltration, and alleviating lumbar and leg pain in patients with lumbar disc herniation (LDH). Specifically, acupuncture significantly increases the cross-sectional areas (Sm, Se, Sp) of the paraspinal muscles and reduces muscle fat infiltration, showing superior long-term results in pain relief and functional improvement. Future research should further explore the long-term effects of acupuncture on the function and structure of paraspinal muscles, assess its potential in preventing the recurrence of LDH, and delve deeper into how acupuncture affects paraspinal muscles at the molecular level, to better understand its therapeutic mechanisms and enhance its clinical application.
Predictive analysis of osteoarthritis and chronic pancreatitis comorbidity: complications and risk factors
Authors: Halabitska Iryna , Petakh Pavlo , Oksenych Valentyn , Kamyshnyi Oleksandr 
Published: November 2024

BackgroundThe comorbidity of chronic pancreatitis (CP) in patients with osteoarthritis (OA) is insufficiently studied, and the reciprocal impact of these conditions remains poorly understood. This study aimed to investigate potential predictors for the development of CP in OA patients, as well as associated complications.MethodsA cohort of 181 patients was categorized into four groups: a control group (n=30), patients with OA (n=68), patients with CP (n=31), and patients with OA and comorbid CP (n=52). All four groups had no statistical differences in age and gender. The study utilized the WOMAC index, Visual Analog Scale (VAS), Lequesne index, biochemical assays, and advanced statistical methods to assess joint status in OA patients with comorbid CP. It explored potential predictors of comorbidity development and associated complications.ResultsThe study revealed that concurrent CP in OA exacerbates progression and contributes to malnutrition. Body Mass Index (BMI) emerged as a potential predictor for CP comorbidity development in OA patients. Factors such as the WOMAC total score, fecal elastase-1, C-reactive protein (CRP), ferritin, retinol, tocopherol, 25-hydroxyvitamin D3, and BMI were found to influence the development of comorbidity of CP in OA. Additionally, Gastrointestinal Symptom Rating Scale-Diarrhea Syndrome (GSRS-DS), Gastrointestinal Symptom Rating Scale-Constipation Syndrome (GSRS-CS), Qualitative Assessment of the Symptoms and Impact of Pancreatic Exocrine Insufficiency Domain A (PEI-Q-A), retinol, tocopherol, and iron were identified as potential predictors comorbidity CP with exocrine pancreatic insufficiency in OA patients.ConclusionThe presence of CP in OA patients exacerbates disease progression and complications, necessitating further investigation.
A polygenic risk score model for psoriasis based on the protein interactions of psoriasis susceptibility loci
Authors: Antonatos Charalabos , Koskeridis Fotios , Ralliou Christiana M. , Evangelou Evangelos , Grafanaki Katerina , Georgiou Sophia , Tsilidis Konstantinos K. , Tzoulaki Ioanna , Vasilopoulos Yiannis 
Published: November 2024

IntroductionPolygenic Risk Scores (PRS) are an emerging tool for predicting an individual’s genetic risk to a complex trait. Several methods have been proposed to construct and calculate these scores. Here, we develop a biologically driven PRS using the UK BioBank cohort through validated protein interactions (PPI) and network construction for psoriasis, incorporating variants mapped to the interacting genes of 14 psoriasis susceptibility (PSORS) loci, as identified from previous genetic linkage studies.MethodsWe constructed the PPI network via the implementation of two major meta-databases of protein interactions, and identified variants mapped to the identified PSORS-interacting genes. We selected only European unrelated participants including individuals with psoriasis and randomly selected healthy controls using an at least 1:4 ratio to maximize statistical power. We next compared our PPI-PRS model to (i) clinical risk models and (ii) conventional PRS calculations through p-value thresholding.ResultsOur PPI-PRS model provides comparable results to both clinical risk models and conventional approaches, despite the incorporation of a limited number of variants which have not necessarily reached genome-wide significance (GWS). Exclusion of variants mapped to the HLA-C locus, an established risk locus for psoriasis resulted in highly similar associations compared to our primary model, indicating the contribution of the genetic variability mapped to non-GWS variants in PRS computations.DiscussionOur findings support the implementation of biologically driven approaches in PRS calculations in psoriasis, highlighting their potential clinical utility in risk assessment and treatment management.
A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma
Authors: Wang Yizhuo , Wang Xin , Liu Yang , Xu Jiayuan , Zhu Jiyuan , Zheng Yufu , Qi Quan 
Published: November 2024

BackgroundImmunotherapy has shown considerable promise in cancer treatment, yet only a minority of osteosarcoma patients derive benefits from this approach. Hypoxia and lactate metabolism are two predominant characteristics of the tumor microenvironment. These features are crucial for molding the immune landscape and thus have the potential to act as predictive indicators for immunotherapy response.MethodsPrognostic modeled genes were identified through univariate and multivariate Cox regression as well as LASSO regression analyses. The tumor microenvironment was evaluated using ESTIMATE, CIBERSORT, and ImmuCellAI analyses. Tide prediction and expression of immune checkpoints, MHC molecules, chemokines, interleukins, interferons, receptors, and other cytokines were utilized to estimate immunotherapy efficacy. Single-cell analysis was performed to demonstrate the expression of modeled genes among various immune cell types. Experimental validation was carried out to verify the expression and functions of SFXN4 and SQOR.ResultsA potent signature was constructed with 8 genes related to hypoxia and lactate metabolism, including MAFF, COL5A2, FAM162A, SQOR, UQCRB, SFXN4, PFKFB2 and COX6A2. A nomogram incorporating risk scores and other clinical features demonstrated excellent predictive capacity. Osteosarcoma patients with high-risk scores exhibited poor prognosis and more “cold” tumor characteristics. According to the ESTIMATE algorithm, these patients displayed lower immune, stromal, and ESTIMATE scores, partially attributed to inadequate infiltration of key immunocytes. The Ciborsort analysis similarly indicated that high-risk individuals had diminished infiltration of critical anti-tumor immune cells such as Cytotoxic T cells, CD4+ T cells, and NK cells. The low expression levels of certain immune checkpoints, MHC molecules, chemokines, interleukins, interferons, receptors, and other cytokines in high-risk cases suggested their unsatisfactory responses to immune treatment. Tide prediction further demonstrated that fewer individuals classified as high risk may exhibit sensitivity to immune checkpoint inhibitor therapy. Notably, SFXN4 was found to be highly expressed in osteosarcoma tissues and cells; it promoted the growth, migration, and invasion of osteosarcoma cells, while SQOR had the opposite effect.ConclusionOur research has developed a robust hypoxia- and lactate metabolism-related gene signature, providing a solid theoretical foundation for prognosis prediction, classification of “cold” and “hot” tumors, accessing immunotherapy response, and directing personalized treatment for osteosarcoma.