bluuebunny/crossref_metadata_2025_split huggingface dataset:
Price Discovery in Agricultural Futures Markets: Should We Look beyond the Best Bid‐Ask Spread?
Authors: Arzandeh Mehdi , Frank Julieta 
Published: January 2019

AbstractPrice discovery is the incorporation of information to prices through the actions of traders. Previous studies in financial markets have found evidence that informed traders may submit limit orders instead of market orders as part of their trading strategies. If so, the steps of limit order book (LOB) beyond the best bid and best ask spread (BAS) may contain valuable information and contribute to price discovery of the underlying asset. This is the first attempt to examine the informativeness of the LOB beyond the BAS for agricultural commodities. We reconstruct the LOB using market depth data and use three information share approaches to test to what extent the steps of LOB beyond the BAS contribute to price discovery. This is done for five major agricultural commodities, namely live cattle, lean hogs, corn, wheat, and soybeans, as well as the E‐mini Standard and Poor's 500 Index (S&P 500) futures contracts. The results show that the steps of the LOB beyond the BAS contribute by over 27% to price discovery of futures contracts. Across agricultural commodities, the steps of the LOB beyond the BAS have more information for grains than meats. Moreover, beyond the BAS, the steps closer to the top of the book contain more information for livestock and E‐mini S&P 500. For grains, the steps farther from the BAS are as informative as the steps closer to the BAS. These findings suggest that informed traders in futures electronic markets actively use limit orders with price steps beyond the BAS.
Development of an antimicrobial stewardship program in an integrated healthcare system
Authors: Lane Michael A , Hays Amanda J , Newland Helen , Zack Jeanne E , Guth Rebecca M , Newland Jason G 
Published: January 2019

Abstract

Purpose
The development of an inpatient antimicrobial stewardship program (ASP) in an integrated healthcare system is described.

Summary
With increasing national focus on reducing inappropriate antimicrobial use, state and national regulatory mandates require hospitals to develop ASPs. In 2015, BJC HealthCare, a multihospital health system, developed a system-level, multidisciplinary ASP team to assist member hospitals with ASP implementation. A comprehensive gap analysis was performed to assess current stewardship resources, activities and compliance with CDC core elements at each facility. BJC system clinical leads facilitated the development of hospital-specific leadership support statements, identification of hospital pharmacy and medical leaders, and led development of staff and patient educational components. An antimicrobial-use data dashboard was created for reporting and tracking the impact of improvement activities. Hospital-level interventions were individualized based on the needs and resources at each facility. Hospital learnings were shared at bimonthly system ASP meetings to disseminate best practices. The initial gap analysis revealed that BJC hospitals were compliant in a median of 6 ASP elements (range, 4–8) required by regulatory mandates. By leveraging system resources, all hospitals were fully compliant with regulatory requirements by January 2017.

Conclusion
BJC’s ASP model facilitated the development of broad-based stewardship activities, including education modules for patients and providers and clinical decision support, while allowing hospitals to implement activities based on local needs and resource availability.
Coccidioidal Meningitis in New York Traced to Texas by Fungal Genomic Analysis
Authors: Barker Bridget M , Rajan Sujatha , De Melo Teixeira Marcus , Sewnarine Michelle , Roe Chandler , Engelthaler David M , Galgiani John N 
Published: January 2019

Abstract
A child developed hydrocephalus. Sixteen months later, it was discovered to be a complication of coccidioidal meningitis. The infection’s source was uncertain until genomic analysis of the fungal isolate identified its origin to be a visit to Beeville, Texas. Improved national reporting of cases of coccidioidomycosis might reduce diagnostic delays.
Oxalate nephropathy is a major cause of kidney injury in surgically treated pancreatic adenocarcinoma patients
Authors: Desbuissons Geoffroy , Izzedine Hassan , Bardier Armelle , Dubreuil Olivier , Vaillant Jean Christophe , Frochot Vincent , Mercadal Lucile 
Published: January 2019

Abstract

Background
Despite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described.

Methods
Patients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed.

Results
Two hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy.

Conclusion
Although rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.
A current understanding of drug-induced QT prolongation and its implications for anticancer therapy
Authors: Roden Dan M 
Published: January 2019

Abstract
The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases such as diabetes. Many drugs produce a small but reproducible effect on QT interval but in rare instances this is exaggerated and marked QT prolongation can provoke the polymorphic ventricular tachycardia ‘torsades de pointes’, which can cause syncope or sudden cardiac death. The generally accepted common mechanism whereby drugs prolong QT is block of a key repolarizing potassium current in heart, IKr, generated by expression of KCNH2, also known as HERG. Thus, evaluation of the potential that a new drug entity may cause torsades de pointes has relied on exposure of normal volunteers or patients to drug at usual and high concentrations, and on assessment of IKr block in vitro. More recent work, focusing on anticancer drugs with QT prolonging liability, is defining new pathways whereby drugs can prolong QT. Notably, the in vitro effects of some tyrosine kinase inhibitors to prolong cardiac action potentials (the cellular correlate of QT) can be rescued by intracellular phosphatidylinositol 3,4,5-trisphosphate, the downstream effector of phosphoinositide 3-kinase. This finding supports a role for inhibition of this enzyme, either directly or by inhibition of upstream kinases, to prolong QT through mechanisms that are being worked out, but include enhanced inward ‘late’ sodium current during the plateau of the action potential. The definition of non-IKr-dependent pathways to QT prolongation will be important for assessing risk, not only with anticancer therapies but also with other QT prolonging drugs and for generating a refined understanding how variable activity of intracellular signalling systems can modulate QT and associated arrhythmia risk.
Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention
Authors: Kessler Thorsten , Wolf Bernhard , Eriksson Niclas , Kofink Daniel , Mahmoodi Bakhtawar K , Rai Himanshu , Tragante Vinicius , Åkerblom Axel , Becker Richard C , Bernlochner Isabell , Bopp Roman , James Stefan , Katus Hugo A , Mayer Katharina , Munz Matthias , Nordio Francesco , O’Donoghue Michelle L , Sager Hendrik B , Sibbing Dirk , Solakov Linda , Storey Robert F , Wobst Jana , Asselbergs Folkert W , Byrne Robert A , Erdmann Jeanette , Koenig Wolfgang , Laugwitz Karl-Ludwig , ten Berg Jurrien M , Wallentin Lars , Kastrati Adnan , Schunkert Heribert 
Published: January 2019

AbstractAimA common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention.Methods and resultsThe association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry. The clinical outcome cardiovascular death or stent thrombosis within 30 days after stenting was investigated in a meta-analysis of substudies of the ISAR-ASPI registry, the PLATO trial (n = 3236), and the Utrecht Coronary Biobank (n = 1003) comprising a total 5917 patients. Homozygous GUCY1A3 risk allele carriers (GG) displayed increased on-aspirin platelet reactivity compared with non-risk allele (AA/AG) carriers [150 (interquartile range 91–209) vs. 134 (85–194) AU⋅min, P < 0.01]. More homozygous risk allele carriers, compared with non-risk allele carriers, were assigned to the high-risk group for ischaemic events (>203 AU⋅min; 29.5 vs. 24.2%, P = 0.02). Homozygous risk allele carriers were also at higher risk for cardiovascular death or stent thrombosis (hazard ratio 1.70, 95% confidence interval 1.08–2.68; P = 0.02). Bleeding risk was not altered.ConclusionWe conclude that homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity. Whether GUCY1A3 genotype helps to tailor antiplatelet treatment remains to be investigated.
CLT for Fluctuations of Linear Statistics in the Sine-beta Process
Authors: Leblé Thomas 
Published: January 2019

Abstract
We prove, for any $\beta&gt;0$, a central limit theorem for the fluctuations of linear statistics in the $\textrm{Sine}_{\beta }$ process, which is the infinite volume limit of the random microscopic behavior in the bulk of one-dimensional log-gases at inverse temperature $\beta $. If $\overline{\varphi }$ is a compactly supported test function of class $C^4$, and ${\mathcal{C}}$ is a random point configuration distributed according to $\textrm{Sine}_{\beta }$, the integral of $\overline{\varphi }(\cdot / \ell )$ against the random fluctuation $d{\mathcal{C}} - dx$ converges in law, as $\ell $ goes to infinity, to a centered normal random variable whose standard deviation is proportional to the Sobolev $H^{1/2}$ norm of $\overline{\varphi }$ on the real line. The proof relies on the Dobrushin–Landford–Ruelle equations for $\textrm{Sine}_{\beta }$ established by Dereudre–Hardy–Maïda and the author, the Laplace transform trick introduced by Johansson, and a transportation method previously used for $\beta $-ensembles at macroscopic scale.
Evidence for Household Transmission of Rotavirus in the United States, 2011–2016
Authors: Wikswo Mary E , Parashar Umesh D , Lopman Benjamin , Selvarangan Rangaraj , Harrison Christopher J , Azimi Parvin H , Boom Julie A , Sahni Leila C , Englund Janet A , Klein Eileen J , Staat Mary Allen , McNeal Monica M , Halasa Natasha , Chappell James , Weinberg Geoffrey A , Szilagyi Peter G , Esona Mathew D , Bowen Michael D , Payne Daniel C 
Published: January 2019

AbstractBackgroundRotavirus is a leading cause of acute gastroenteritis (AGE) in children and is highly transmissible. In this study, we assessed the presence of AGE in household contacts (HHCs) of pediatric patients with laboratory-confirmed rotavirus.MethodsBetween December 2011 and June 2016, children aged 14 days to 11 years with AGE were enrolled at 1 of 7 hospitals or emergency departments as part of the New Vaccine Surveillance Network. Parental interviews, medical and vaccination records, and stool specimens were collected at enrollment. Stool was tested for rotavirus by an enzyme immunoassay and confirmed by real-time or conventional reverse transcription-polymerase chain reaction assay or repeated enzyme immunoassay. Follow-up telephone interviews were conducted to assess AGE in HHCs the week after the enrolled child’s illness. A mixed-effects multivariate model was used to calculate odds ratios.ResultsOverall, 829 rotavirus-positive subjects and 8858 rotavirus-negative subjects were enrolled. Households of rotavirus-positive subjects were more likely to report AGE illness in ≥1 HHC than were rotavirus-negative households (35% vs 20%, respectively; P &lt; .0001). A total of 466 (16%) HHCs of rotavirus-positive subjects reported AGE illness. Of the 466 ill HHCs, 107 (23%) sought healthcare; 6 (6%) of these encounters resulted in hospitalization. HHCs who were &lt;5 years old (odds ratio, 2.2 [P = .004]) were more likely to report AGE illness than those in other age groups. In addition, 144 households reported out-of-pocket expenses (median, $20; range, $2–$640) necessary to care for an ill HHC.ConclusionsRotavirus-associated AGE in children can lead to significant disease burden in HHCs, especially in children aged &lt;5 years. Prevention of pediatric rotavirus illness, notably through vaccination, can prevent additional illnesses in HHCs.
Environmental impacts on molecular gas in protocluster galaxies at z ∼ 2
Authors: Tadaki Ken-ichi , Kodama Tadayuki , Hayashi Masao , Shimakawa Rhythm , Koyama Yusei , Lee Minju , Tanaka Ichi , Hatsukade Bunyo , Iono Daisuke , Kohno Kotaro , Matsuda Yuichi , Suzuki Tomoko L , Tamura Yoichi , Toshikawa Jun , Umehata Hideki 
Published: January 2019

Abstract
We present the results from ALMA CO(3–2) observations of 66 Hα-selected galaxies in three protoclusters around radio galaxies: PKS 1138−262 ($z$ = 2.16), USS 1558−003 ($z$ = 2.53), and 4C 23.56 ($z$ = 2.49). The pointing areas have an overdensity of ∼100 compared to the mean surface number density of galaxies in field environments. We detect the CO emission line in 16 star-forming galaxies, including six previously published galaxies, to measure the molecular gas mass. In the stellar mass range of 10.5 &lt; log (Mstar/M⊙) &lt; 11.0, the protocluster galaxies have larger gas mass fractions and longer gas depletion timescales compared to the scaling relations established for field galaxies. On the other hand, the amounts of molecular gas in more massive galaxies with log (Mstar/M⊙) &gt; 11.0 are comparable in mass to the scaling relation, or smaller. Our results suggest that the environmental effects on gas properties are mass dependent: in high-density environments, gas accretion through cosmic filaments is accelerated in less massive galaxies, while this is suppressed in the most massive system.
How guideline can shape clinical practice globally: the diagnosis and rationale for action against cow's milk allergy experience
Authors: Dahdah Lamia , Arasi Stefania , Valluzzi Rocco Luigi , Fierro Vincenzo , Fiocchi Alessandro 
Published: January 2019

Purpose of review
Allergic diseases are increasing worldwide and are considered an important public health problem causing severe and even life-threatening reactions. The creation of guidelines aims to help clinicians improving the quality of diagnosis and management of such diseases. Clinical practice guidelines alone are not sufficient and there is a need for implementation strategies for their introduction into daily practice. We report here the main international allergy guidelines with a more focused look on the Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines and their effect on clinical practice.

Recent findings
DRACMA guidelines have clearly modified the approach to cow's milk allergy (CMA) from its diagnosis to treatment tailoring the choices for each patient. Although they strongly recommend oral food challenge for diagnosing CMA, they also indicate that it may not be necessary in many cases with the introduction of the pretest probability of CMA. Studies on the implementation of DRACMA guidelines show how they influenced the formula market, making appropriate treatments more affordable.

Summary
DRACMA reconciled international differences in the diagnosis and management of CMA. They introduced the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology in the field of food allergy and highlighted the importance for meta-analyses to be able to adapt recommendations to the local context.
Designated Interpreters: A Model to Promote the Diversity and Inclusion of Deaf Professionals in Academic Medicine
Authors: Hall Wyatte C. , Elliott Marlene , Cullen John P. 
Published: January 2019

Problem
Deaf professionals who use American Sign Language (ASL) are a growing population in academic medicine. Reasonable accommodations for this group include providing an ASL interpreter. Many institutions contract with external agencies to provide ad hoc interpreters, but this model has hidden costs for deaf professionals and institutions.

Approach
The University of Rochester School of Medicine and Dentistry (URSMD) uses the designated interpreter model in which interpreters are on staff and embedded with deaf professionals so they can learn both the work environment and the deaf professionals’ specialized science and medicine content. This model addresses many of the limitations of the external agency approach and better facilitates the inclusion of deaf professionals in the institution.

Outcomes
This model has been in use at URSMD since 1990 but has seen exponential growth recently (increasing from 3 deaf professionals with designated interpreters in 2011 to a peak of 17 in 2016). Designated interpreters have worked in different research and clinical settings from dentistry and nursing to community and global health. This growth highlights the increasing number of deaf professionals in medicine and the need to train more designated interpreters.

Next Steps
In response to this growing demand, URSMD is developing an ASL Interpreting in Medicine and Science program, a master’s degree–level program to train interpreters who are bilingual in ASL and English to be designated interpreters. The designated interpreter model is one step toward creating an environment that is fully inclusive of deaf professionals to the benefit of the whole institution.
Reconstruction of Lumbar Spinal Defects: Case Series, Literature Review, and Treatment Algorithm
Authors: Daly Lauren T. , Amador Ricardo O. , Shin John H. , Bojovic Branko , Eberlin Kyle R. 
Published: January 2019

Background:
Lumbar spinal defects present a distinct challenge for the reconstructive surgeon and are often complicated by previous spinal surgery, the presence of hardware, and prior radiation. There are a variety of reconstructive options described but no clear treatment algorithm for these challenging defects.

Methods:
A literature search was performed to review the described treatment options for lumbar spinal soft-tissue defects. Treatments for myelomeningocele or pressure ulcers were excluded. In addition, a retrospective case review was performed for patients with lumbar defects treated with pedicled superior gluteal artery perforator (SGAP) flap reconstruction.

Results:
A literature review revealed 2,022 articles pertaining to lumbar defect reconstruction, of which 56 met inclusion criteria. These articles described 13 individual reconstructive techniques for this anatomic area. The most commonly described techniques were evaluated and a treatment algorithm designed based on patient and wound characteristics. The clinical course of 5 patients with radiated lumbar spinal defects treated with SGAP flaps is presented.

Conclusions:
There are many treatment options for lumbar spinal defects and treatment should be tailored to the patient and the characteristics of the defect. For large or radiated lumbar wounds, the pedicled SGAP flap is an excellent reconstructive choice, as it has reliable anatomy that is outside the zone of injury, adequate bulk, and minimal donor-site deficits.
SUBFOVEAL CHOROIDAL THICKNESS AND VASCULAR ARCHITECTURE IN FELLOW EYES OF PATIENTS WITH CIRCUMSCRIBED CHOROIDAL HEMANGIOMA
Authors: Sobol Ethan K. , Francis Jasmine H. , Abramson David H. , Freund K. Bailey , Spaide Richard F. , Barbazetto Irene 
Published: January 2019

Purpose:
To evaluate the subfoveal choroidal thickness (SFCT) and vascular architecture in the fellow eyes of patients with circumscribed choroidal hemangioma (CCH).

Methods:
In this retrospective observational study, patients were selected from outpatient ophthalmology clinics at the Memorial Sloan Kettering Cancer Center and Vitreous Retina Macula Consultants of New York. Subfoveal choroidal thickness was measured using enhanced depth imaging spectral domain optical coherence tomography from the outer portion of Bruch membrane to the choroidal–scleral interface. Choroidal vascular architecture was qualitatively examined. The main outcome measure was SFCT in fellow eyes of patients with CCH, which was compared with an age- and gender-matched control group.

Results:
Thirty-one fellow eyes (15 right eyes and 16 left eyes) of patients with CCH (23 males and 8 females) were examined. The fellow eye had a mean SFCT of 361.2 ± 99.9 μm compared with 252.0 ± 77.6 μm in the control group (P < 0.0001). Vascular architecture was disorganized in 13 (42%) fellow eyes and 1 (3%) control eye (P < 0.0001), with no apparent gradient of vessel sizes or discrete choroidal layers. The normal association between older age and a thinner choroid existed in control eyes but not in fellow eyes. Hemangioma thickness measured by ultrasound and the presence of subfoveal fluid in the CCH eye did not correlate with the fellow-eye SFCT.

Conclusion:
In patients with CCH, fellow eyes had thicker SFCT when compared with age- and gender-matched control eyes. Choroidal architecture was often irregular, without segmented vascular layers. These findings suggest that inherent choroidal changes may exist in patients with CCH.
Analysis of Airway and Midface in Crouzon Syndromes
Authors: Forte Antonio J. , Lu Xiaona , Hashim Peter W. , Steinbacher Derek M. , Alperovich Michael , Persing John A. , Alonso Nivaldo 
Published: January 2019

Background
Crouzon syndrome is associated with severe respiratory impairment of the upper airway due in part to midfacial dysmorphology. We calculated the distinctive nasal diameter and pharyngeal airway volume in patients with Crouzon syndrome and compared them with age-matched control subjects.

Methods
Children with computed tomography scans in the absence of surgical intervention were included. Computed tomography scans were digitized and manipulated using Surgicase CMF (Materialise). Craniometric data relating to the midface and airway were collected. For all linear measurements, mean percent increases or decreases were calculated relative to the size of control subjects, and volumetric assessment of the airway was tabulated. Statistical analysis was performed using t test.

Results
Twenty-six computed tomography scans were included (control n = 17, Crouzon n = 9). All children were in early mixed dentition. Pharyngeal airway volume was decreased in patients with Crouzon syndrome relative to control subjects by 46% (P = 0.003). The distance from the posterior tongue to the posterior pharyngeal wall decreased 31% when comparing the Crouzon group versus the control (P = 0.04).

Conclusions
Three-dimensional analysis revealed notably decreased pharyngeal and nasal airway volumes in patients with Crouzon syndrome, but nasal bone tissue and soft tissue measurements showed very little change between patients and control subjects.