bluuebunny/crossref_metadata_2025_split huggingface dataset:
MD-LBP: An Efficient Computational Model for Protein Subcellular Localization from HeLa Cell Lines Using SVM
Authors: Tahir Muhammad , Idris Adnan 
Published: July 2019

Background:
The knowledge of subcellular location of proteins is essential to the comprehension
of numerous protein functions.

Objective:
Accurate as well as computationally efficient and reliable automated analysis of protein
localization imagery greatly depend on the calculation of features from these images.

Methods:
In the current work, a novel method termed as MD-LBP is proposed for feature extraction
from fluorescence microscopy protein images. For a given neighborhood, the value of central
pixel is computed as the difference of global and local means of the input image that is further
used as threshold to generate a binary pattern for that neighborhood.

Results:
The performance of our method is assessed for 2D HeLa dataset using 5-fold crossvalidation
protocol. The performance of MD-LBP method with RBF-SVM as base classifier, is
superior to that of standard LBP algorithm, Threshold Adjacency Statistics, and Haralick texture
features.

Conclusion:
Development of specialized systems for different kinds of medical imagery will certainly
pave the path for effective drug discovery in pharmaceutical industry. Furthermore, biological
and bioinformatics based procedures can be simplified to facilitate pharmaceutical industry for
drug designing.
Breaking the Barrier of Cancer through Papaya Extract and their Formulation
Authors: Saha Sumana , Giri Tapan Kumar 
Published: July 2019

Background:In the last decade, many new avenues of cancer treatment have opened up but the costs of treatment have sky-rocketed too. Hence, screening of indigenously available plant and animal resources for anti-carcinogenic potential is an important branch of anticancer research. The effort has been made through this comprehensive review to highlight the recent developments of anticancer therapies using different parts of papaya plant extract.Methods:In search of the naturally existing animals and plants for anticarcinogenic potential, papaya plant has been exploited by the scientist working in this research field. A widespread literature search was performed for writing this review.Results:Different constituents of Carica papaya responsible for anticancer activities have been discussed. Papaya extract for the treatment of breast, liver, blood, pancreas, skin, prostate, and colon cancer have also been reported. Finally, the various formulation approach using Carica papaya extract have been highlighted.Conclusion:The information provided in this review might be useful for researchers in designing of novel formulation of Carica papaya extract for the treatment of cancer.
Protection from Radiation-induced Damage in Rat’s Ileum and Colon by Combined Regimens of Melatonin and Metformin: A Histopathological Study
Authors: Najafi Masoud , Cheki Mohsen , Hassanzadeh Gholamreza , Amini Peyman , Shabeeb Dheyauldeen , Musa Ahmed E. 
Published: July 2019

Background:
Radiation-induced enteritis and proctitis are common side effects
of abdominopelvic cancers among patients that undergo radiotherapy for prostate, colorectal
or urinary cancers. Exposure of these tissues to high doses of radiation leads to damage
to villous, inflammation, pain, ulcer and bleeding, which may cause malabsorption and
gastrointestinal disorders. To date, several procedures such as pharmaceutical treatment
have been proposed for protection and mitigation of gastrointestinal toxicity following radiotherapy.

Aims:
In the current study, we aimed to investigate the possible radioprotection of ileum
and colon in rats using a combination of melatonin and metformin.

Methods:
In this experimental study, 30 male Wistar rats were randomly assigned to six
groups: control, melatonin (100 mg/kg) treatment, melatonin (100 mg/kg) plus metformin
(100 mg/kg) treatment, radiation (10 Gy to whole body) group, radiation + melatonin (100
mg/kg) treatment, and radiation + melatonin (100 mg/kg) plus metformin (100 mg/kg)
treatment. After 3.5 days, rats were sacrificed and their ileum and colon tissues carefully
removed. Histopathological evaluations were conducted on these tissue samples.

Results:
Histological evaluations reported moderate to severe damages to ileum and colon
following whole body irradiation. Melatonin administration was able to protect the ileum
remarkably, while the combination of melatonin and metformin was less effective. Interestingly,
for the colon, melatonin was less effective while its combination with metformin
was able to protect against radiation toxicity completely.

Conclusion:
For the ileum, melatonin was a more effective radioprotector compared to its
combination with metformin. However, the combination of melatonin and metformin can
be proposed as an ideal radioprotector for the colon.
Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives
Authors: Verma Krishan Kumar , Singh Umesh Kumar , Jain Jainendra 
Published: July 2019

Background:
In the present study, 4, 5-disubstituted triazol-3-thione derivatives were
synthesized and evaluated for anticonvulsant activity along with neurotoxicity determination.

Materials and Methods:
The synthesized compounds were characterized using FTIR, 1H-NMR
and MS. The anticonvulsant activity was assessed by Maximal Electroshock (MES) test and subcutaneous
Pentylenetetrazole (scPTZ) tests and neurotoxicity was assessed by rotarod test. Docking
was also performed to study the interactions of compounds with LYS329 residue of gamma
amino butyric acid aminotransferase (GABA-AT) using Autodock 4.2 software.

Results:
The compounds 7a and 9a with significant pharmacological activity were also found to
interact with LYS329 residue of GABA-AT by H-bond with a docking score of -5.92 kcal/mol
(Ki = 41.99 μM) and -5.87 kcal/mol (Ki = 49.83 μM) respectively.

Conclusion:
Most of the compounds were found to be active in MES test but only seven showed
protection in scPTZ test.
Impact of Leukemia Stem Cells Phenotype Expression on Response to Induction Therapy in Acute Myeloid Leukemia Patients
Authors: Almohsen Faez , Al-Mudallal Subh S. 
Published: July 2019

Background:
Laboratory data suggest that acute myeloid leukemia AML originates from
a rare population of cells, termed Leukemic Stem Cells (LSCs) or leukemia-initiating cells, which
are capable of self-renewal, proliferation and differentiation into malignant blasts. There is a
universal agreement that LSCs lie within the CD34+ compartment of hemopoietic cells and most of
leukemic stem cells express the interleukin-3 alpha chain receptor, CD123 and lack CD38. This
study aimed to estimate the expression of LSC phenotype in AML patients and to correlate it with
response to induction therapy.

Methods:
A cohort of 41 patients older than 15 years with newly diagnosed de novo AML were
enrolled in this study. They were obtained from the National center of hematology in Baghdad and
Baghdad teaching hospital between February and July 2013. The expression of CD34, CD38 and
CD123 was assessed by multi-color flow cytometry. LSC positive (LSC+) samples must express
CD34 and CD123 and lack the expression of CD38 in >1% of cells. French American British
(FAB) classification system was used in this study.

:
After four weeks of induction therapy; three groups were found: those who reached the Complete
morphological Remission (CR), those who failed to reach CR and those who died before the
assessment of morphological remission. The last two groups were merged for statistical purposes.

Results:
After the course of induction therapy, 41.46% of patients had complete morphological
remission while 58.54% of the studied patients failed to reach complete remission. The Complete
Remission (CR) rate was higher (53.33%) in patients who were negative for LSC phenotype than
patients who were positive for LSC phenotype (34.61%).

Conclusions:
LSCs were expressed in 63.41% of AML cases and were in approximate distribution
in FAB M3 and non-M3 patients. The expression of LSC phenotype was associated with poor
response to induction therapy in AML patients.
Comparison of the Effects of Dexamethasone Administration on Postoperative Sequelae Before and After “Third Molar" Extraction Surgeries
Authors: Shoohanizad Ehsan , Parvin Milad 
Published: July 2019

Introduction:Impacted third molars (ITMs) surgery, is one of the most common methods in the field of oral and maxillofacial surgical operations. Administration of corticosteroid such as dexamethasone diminishes the postoperative sequelae. The study aimed to compare the impact of dexamethasone administration on pre-operative and post-operative complications in third molar surgery.Methods:We collected all randomized controlled trial data on the influences of pre-operative and postoperative dexamethasone administration between 2006-2019 on third molar surgery sequelae by searching the keywords: dexamethasone, third molar surgery, wisdom teeth, corticosteroids, oral surgery, maxillofacial surgery, preoperative, postoperative, pain, swelling, and trismus in international databases such as: Web of Science (ISI), PubMed, Scopus, Embase and Cochrane Library.Results:Twenty-three articles were included in this narrative review. Among them, 22 studies used dexamethasone in particular and 1 study used dexamethasone with amoxicillin. Twenty studies evaluated the prescription of dexamethasone in pre-operative and post-operative routes on pain, trismus and edema following third molars operation. Five studies administered dexamethasone postoperatively and 15 studies administered the drug preoperatively. Two studies evaluated the preoperative and postoperative administration method. Fourteen studies used a 4 mg dexamethasone dose and drug administration was variable. The treatment period in postoperative studies varied between 1 to 7 days.Conclusion:Dexamethasone appears to be a promising agent in in reduction of post-operative complications following third molar surgery. As a potent anti-inflammatory agent, it has an effective role in pain, trismus and edema reduction distinguished from the routes of administration, dosage and timing, pre or postoperative prescription.
African Walnuts (Tetracarpidium conophorum) Modulate Hepatic Lipid Accumulation in Obesity via Reciprocal Actions on HMG-CoA Reductase and Paraoxonase
Authors: Uti Daniel E. , Atangwho Item J. , Eyong Eyong U. , Umoru Grace U. , Egbung Godwin E. , Rotimi Solomon O. , Nna Victor U. 
Published: July 2019

Background:Obesity is characterized by increased body fat and involves an imbalance between the synthesis and degradation of lipids.Objective:The study aimed to investigate the effect of African walnuts (Tetracarpidium conophorum) on lipids storage and the regulatory enzymes of hepatic lipid metabolism in obese rats.Methods:Nuts were extracted in ethanol (WE) and further separated to obtain the ethyl-acetate fraction (ET) and the residue (RES). These were administered orally to 3 groups of monosodium glutamate- obese rats (n = 6), respectively, for 6 weeks. Other groups in the study were: normal (NC), obese control (OC) and standard control (SC) which received orlistat. Hepatic total lipids, total phospholipids, triacylglycerol (TG), total cholesterol (TCHOL), 3-hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase and paraoxonase were studied.Results:Total lipids, TG and TCHOL which increased in OC compared to NC group, decreased. HMG-CoA reductase activity decreased in the 3 study groups relative to OC. Paraoxonase activity which decreased in OC was up-regulated, while the magnitude of hepatic cholesterol decreased from 94.32 % in OC to 52.19, 65.43 and 47.04 % with WE, ET and RES, respectively. Flavonoids, alkaloids, glycosides, tannins and saponins were detected in the nut. GC-MS analysis revealed 16, 18 and 10 volatile components in WE, ET and RES, respectively. Unsaturated fatty acids (linolenic acids: 33.33, 47.95 and 50.93 %, and α-linolenic acids: 25, 19.66 and 26.63 %) in WE, ET and RES, respectively, are the most abundant, and likely to be responsible for the observed activity.Conclusion:African walnuts can prevent hepatic lipid accumulation through reciprocal actions on HMG-CoA reductase and paraoxonase in obesity.
Vitamin E-based Folic Acid Nanoemulsion: Formulation and Physical Evaluation for Oral Administration
Authors: Adi Annis Catur , Christanto Christanto , Rachmawati Heni , Adlia Amirah 
Published: July 2019

Background:Folic acid is essential in many metabolic processes and DNA synthesis. Nevertheless, folic acid is not stable, pH-sensitive, and deteriorated upon light exposure.Objective:This work was aimed to improve folic acid stability within vitamin E-based nanoemulsion.Methods:The nanoemulsion was prepared with self-nanoemulsification method by mixing vitamin E oil, Tween 20, and PEG 400. A pseudoternary phase diagram was constructed with aqueous titration to determine the optimum ratio for the mixture. The globule size, pH and entrapment efficiency were included in the nanoemulsion characterizations. In addition, the influence of centrifugation, storage, and pH on physical and chemical stabilities of folic acid nanoemulsion was evaluated.Results:Optimum formula was obtained from vitamin E, Tween 20, and PEG 400 with the ratio of 1:11:1, and the folic acid amount was 8 mg. The size of folic acidloaded oil globule was 15.10 ± 1.51 nm, and the nanoemulsion pH was 6.24 ± 0.01. The nanoemulsion system was able to load the folic acid completely. Folic acid in nanoemulsion was stable after 14 days at room temperature, and it was more stable compared to folic acid in solution. In addition, the physical and chemical characteristics of folic acid in nanoemulsion was not affected by the simulated gastric condition.Conclusion:Hence, nanoemulsion is a promising strategy to enhance folic acid stability.
Smart and Intelligent Stimuli Responsive Materials: An Innovative Step in Drug Delivery System
Authors: Guha Arijit , Shaharyar Md. Adil , Ali Kazi Asraf , Roy Sanjit Kr. , Kuotsu Ketousetuo 
Published: July 2019

Background:In the field of drug delivery, smart and intelligent approaches have gained significant attention among researchers in order to improve the efficacy of conventional dosage forms. Material science has played a key role in developing these intelligent systems that can deliver therapeutic cargo on-demand. Stimuli responsive material based drug delivery systems have emerged as one of the most promising innovative tools for site-specific delivery. Several endogenous and exogenous stimuli have been exploited to devise “stimuli-responsive” materials for targeted drug delivery.Methods:For better understanding, these novel systems have been broadly classified into two categories: Internally Regulated Systems (pH, ionic strength, glucose, enzymes, and endogenous receptors) and Externally Regulated Systems (Light, magnetic field, electric field, ultrasound, and temperature). This review has followed a systematic approach through separately describing the design, development, and applications of each stimuli-responsive system in a constructive manner.Results:The development includes synthesis and characterization of each system, which has been discussed in a structured manner. From advantages to drawbacks, a detailed description has been included for each smart stimuli responsive material. For a complete review in this niche area of drug delivery, a wide range of therapeutic applications including recent advancement of these smart materials have been incorporated.Conclusion:From the current scenario to future development, a precise overview of each type of system has been discussed in this article. In summary, it is expected that researchers working in this novel area will be highly benefited from this scientific review.
Innovaciones sociales para territorios “inteligentes”: ¿ficción o realidad?
Authors: Parada Corrales Jairo 
Published: July 2019

Este ensayo explora los alegatos teóricos acerca de la existencia de territorios “inteligentes”, concepto que ha sido desarrollado recientemente basado en las nociones de sociedad del conocimiento y economía del conocimiento, desarrollo sostenible e inclusión social. Se examinan las condiciones previas para las posibilidades, para la emergencia de este tipo de espacios territoriales en relación con el desarrollo económico que debe respaldarlos, la adecuada estructura social, las cualidades requeridas de agencia humana y las innovaciones sociales que tal propósito exige. Finalmente, como un estudio de caso, se presenta un examen empírico de tales condiciones en la Costa Caribe de Colombia, derivando de allí conclusiones y recomendaciones finales.
Empresas tecnológicas y políticas públicas de desarrollo regional en Brasil
Authors: Miralles Quirós María del Mar , Miralles Quirós José Luis , Daza Izquierdo Julio 
Published: July 2019

El objetivo del presente estudio consiste en analizar el crecimiento empresarial del sector tecnológico de Brasil en el periodo 2002-2013. Para ello, se basa en la Ley de Gibrat o Ley del Efecto Proporcional (LEP) y en la metodología de datos de panel, ya que permite controlar la heterogeneidad inobservable. Sin embargo, a diferencia de la evidencia empírica previa, se tomaron en cuenta el efecto de la reciente crisis financiera y de la rentabilidad sobre el crecimiento empresarial. Los principales resultados obtenidos indican que en épocas de crisis, las políticas públicas podrían dedicar parte de sus recursos disponibles en ayudar a las empresas tecnológicas pequeñas, rentables y menos endeudadas para favorecer el crecimiento económico.
Migración de talentos como estrategia de desarrollo: México-Japón
Authors: Méndez Rodríguez Alejandro 
Published: July 2019

La migración internacional de recursos humanos calificados es uno de los pilares de la gobernanza de la inmigración. Las políticas migratorias establecen los instrumentos de organización y gestión de la misma con la finalidad de atraer trabajadores calificados y estudiantes internacionales en el contexto de la competitividad global. El principal componente que está influyendo en la construcción del flujo migratorio internacional hacia Japón, es el mercado transnacional laboral de recursos calificados y de los mecanismos de su formación. El objetivo de este artículo consiste en señalar los factores socioeconómicos que configuran, impulsan y dan contexto a la movilidad de trabajadores calificados. Y la interrogante principal sería: ¿Cuáles son las características de los principales factores que están moldeando el flujo migratorio entre México y Japón?
Relação de pareceristas Ad Hoc Nº 48
Authors: Editorial Comissão 
Published: July 2019

Relação de pareceristas Ad Hoc - Revista Cadernos de Pesquisa em EducaçãoPROFESSOR (A). DR(A).Profº Roterdan Fernandes AbreuPROFESSOR (A). DR(A).Aline AccorssiPROFESSOR (A). DR(A).Marcela de Moraes AgudoPROFESSOR (A). DR(A).Profº Vinícius Aguiar CalotiPROFESSOR (A). DR(A).Elsi do Rocio Cardoso AlanoPROFESSOR (A). DR(A).onilia cristina de souza almeidaPROFESSOR (A). DR(A).Luana Costa AlmeidaPROFESSOR (A). DR(A).Emanoela Emanoela Celestino Almeida RamosPROFESSOR (A). DR(A).Maria Conceição AlvesPROFESSOR (A). DR(A).Oliveira Herbet Alves AlvesPROFESSOR (A). DR(A).João Paulo da Conceição AlvesPROFESSOR (A). DR(A).Cathia AlvesPROFESSOR (A). DR(A).Guilherme de Souza Vieira AlvesPROFESSOR (A). DR(A).MARCELO PARAISO ALVESPROFESSOR (A). DR(A).Claudia Tavares AmaralPROFESSOR (A). DR(A).Ivair Fernandes de AmorimPROFESSOR (A). DR(A).Antonio AmorimPROFESSOR (A). DR(A).FILIPI VIEIRA AMORIMPROFESSOR (A). DR(A).izabel cristina feijó de andradePROFESSOR (A). DR(A).Francisco Ari AndradePROFESSOR (A). DR(A).Vivian Galdino AndradePROFESSOR (A). DR(A).Gustavo Cunha AraújoPROFESSOR (A). DR(A).Osmar Hélio Alves AraújoPROFESSOR (A). DR(A).Alicia Arias RodríguezPROFESSOR (A). DR(A).Cinthia Magda Fernandes AriosiPROFESSOR (A). DR(A).Roberto Ramon Queiroz de AssisPROFESSOR (A). DR(A).Vivianny Bessão de AssisPROFESSOR (A). DR(A).Douglas Fernandes DouglasPROFESSOR (A). DR(A).Rodrigo Avila CollaPROFESSOR (A). DR(A).Laudinéia Azerêdo Azerêdo dos Santos GomesPROFESSOR (A). DR(A).Alexandre Dido BalbinotPROFESSOR (A). DR(A).Mônica Correia BaptistaPROFESSOR (A). DR(A).Fernanda Suely BarataPROFESSOR (A). DR(A).Ebert BarbosaPROFESSOR (A). DR(A).Sra Vanessa Maia Barbosa de PaivaPROFESSOR (A). DR(A).Sra. Raylane Andreza Dias Navarro BarretoPROFESSOR (A). DR(A).Ms. José Ricardo BatistaPROFESSOR (A). DR(A).Maria Batista LimaPROFESSOR (A). DR(A).Senhora Fernanda Zanetti BecalliPROFESSOR (A). DR(A).Fátima Maria Fátima BelancieriPROFESSOR (A). DR(A).Pamela Tamires Belão FernandesPROFESSOR (A). DR(A).Diego Luís BertolloPROFESSOR (A). DR(A).Marisa BittarPROFESSOR (A). DR(A).Ricardo Luiz de BittencourtPROFESSOR (A). DR(A).Natanael Reis Bomfim
Análise de uma situação-problema: competências socioemocionais e estimulação de funções executivas
Authors: Belli Alexandra , Manrique Ana Lucia 
Published: July 2019

O presente estudo busca analisar a vivência de uma situação-problema em aulas de Matemática nos anos iniciais do Ensino Fundamental de uma escola pública da cidade de São Paulo, atrelada às competências socioemocionais e à resolução de problemas, que contou com a participação de três professores que ensinam Matemática nessa etapa escolar. A pesquisa foi organizada em três partes: a discussão de uma situação-problema, o seu desenvolvimento em sala de aula, e explicitação das percepções sobre a experiência vivida. As considerações finais apontam que a prática pedagógica adotada oportunizou a aprendizagem socioemocional e a habilitação e estimulação de funções executivas, tais como o controle inibitório, a flexibilidade cognitiva e a memória de trabalho.
Palavras-chave: Educação Matemática. Aprendizagem socioemocional. Resolução de problemas. Funções executivas.
Análises acerca do tratamento da derivada no livro didático do ensino superior
Authors: Lobo Rogério 
Published: July 2019

Este artigo, surgiu de algumas inquietações, principalmente da prática ao lecionar a disciplina Cálculo Diferencial e Integral no curso de Engenharia, em especial a derivada, alto índice de reprovação e a não associação (por parte dos estudantes) do significado da derivada como Taxa de Variação. Nossa intenção é analisar como o livro didático aborda a introdução do conceito da derivada com ênfase na Taxa de Variação. Tivemos as contribuições de Pino-Fan et al. (2013) sobre as ideias do sentido holístico da derivada que foi reconstruído por meio do princípio da configuração epistêmica (CE), identificando seus significados parciais. Construímos um quadro para analisar o significado parcial da derivada em um livro didático cruzando os dados das configurações epistêmicas (CE) e os campos de problemas (CP). Concluímos que entre oito configurações epistêmicas se relacionando com cinco campos de problemas, o livro analisado opta pelo significado parcial da derivada como limite.
Palavras-chave: Derivada. Taxa de Variação. Livro Didático.