bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative complication rates in cataract surgery performed by women and men surgeons in a tertiary eye care centre in Hungary
Authors: Magyar M. , Tóth G. , Ujváry L. , Sándor G.L. , Nagy Z.Z. 
Published: December 2024

AbstractPurposeThe aim of our study was to compare intraoperative complication rates in cataract surgeries performed by women and men surgeons and to analyse the possible impact of surgeon–patient gender difference on intraoperative complication rates in a tertiary eye care centre in Hungary.Materials/MethodsThis retrospective study looked at cases of cataract surgery involving phacoemulsification performed between January and December 2019. There were no exclusion criteria. In each case, patient demographics, patient clinical history, surgeon gender, case complexity, and operative details were reviewed. Primary outcomes included intraoperative complication rates.ResultsA total of 2,156 operations were included in the study, 1,295 (60.1%) of which were performed by men surgeons and 861 (39.9%) by women surgeons. The overall complication rate was 4.7% (n = 101). There was no significant difference (P = 0.728) in the intraoperative complication rate between the surgeries performed by women (n = 42, 4.9%) and men (n = 59, 4.6%) in either the simple (P = 0.214) or the complex (P = 0.508) cataract cases. Intraoperative complication rates were analysed in the two surgeon gender groups among both women and men patients. No significant difference was found in any of the compared groups.ConclusionsIntraoperative complication rates were similar in the surgeries performed by women and men specialists. Our study showed that neither surgeon–patient gender difference nor surgeon–patient gender concordance had a significant impact on complication rates during phacoemulsification cataract surgery.
A principled exception to the Müller-Takano Generalization: A belated follow-up to Richards (2004)
Authors: Zompì Stanislao 
Published: December 2024

According to the Müller-Takano Generalization (Müller 1993; Takano 1994), a remnant that contains a trace resulting from a given type of movement cannot itself undergo that same type of movement. I argue that Richards’ (2004) data from Bulgarian “Russian-doll” wh-questions constitute principled exceptions to this generalization under an approach that derives it from a minimality condition on movement paths. Alternative approaches to the generalization have a harder time deriving such exceptions.
Cycling Motilities: Conditions, Weights and Reliefs for Cycling in Disadvantaged Neighbourhoods in Sweden
Authors: Balkmar Dag , Henriksson Malin , Joelsson Tanja 
Published: December 2024

In current Swedish planning and policy discourse, cycling is seen as an efficient way to commute in urban environments and a key component in advancing more sustainable transport. In Sweden, cycling is more prevalent among the more afflu-ent population, but there is (with some exceptions) little knowledge on cycling in low-income areas. Given that well-developed cycling infrastructure is available and that bicycling is a comparably low-cost transport mode, higher rates of cycling in disadvantaged neighbourhoods could be expected. For policies that increase inclu-sive cycling to be implemented, there is a need to understand what makes cycling achievable for diverse groups. Based on the everyday cycling experiences of 31 families living in socially disadvantaged and ethnically diverse neighbourhoods in Sweden, this paper provides qualitative accounts of cycling, knowledge that can inform policy. Key concepts from urban sociology are used to analyse a person’s conditions for cycling. Our findings suggest that while cycling could be considered a practical, social, and flexible mode of transport, especially for younger people, only a few adults in our sample cycled. The results reflect an ambivalence toward cycling as part of everyday mobility. Cycling was perceived as something “typically Swedish”, a norm conditioned by age, gender, and body related weights and reliefs and hard to combine with everyday care- and work responsibilities. The gap between preferred and used mode implies an untapped cycling potential, a finding that suggests that pro cycling policies need to pay increased attention to broader social justice perspectives to support cycling (also) in disadvantaged neighbourhoods.
HERMENEUTICS SITUATION AS THE PHILOSOPHIZING METHOD OF MARTIN HEIDEGGER AND ITS RELEVANCE TO SOCIAL RESEARCH
Authors: Anam Rifqi Khairul 
Published: December 2024

Applying natural science methodologies to the social sciences causes a crisis in science. A crisis of science means the narrowing of researcher subjectivity so the possibility of research heuristics is drastically reduced. Martin Heidegger a philosopher of existentialism tried to solve this problem by developing a method that integrated schools of phenomenology and hermeneutics. This research aims to describe the hermeneutics situation method which embodies the two things above. This research is a type of library research that is descriptive and qualitative. The important value and novelty of this research is that it examines the closeness of philosophy and social science through Martin Heidegger’s way of thinking. A researcher does not live in isolation, he is connected to the context of life in which he lives. The context of life motivates researchers to see the meaning of something. In social research, researchers do not just meet social facts, but meet appropriate events (ereignis). So, social researchers are advised to avoid two things when conducting social research in the context of hermeneutics situation, namely the principle of subject-object division and the value-free principle. The reason is a presumption that a researcher was involved in the surrounding environment which then becomes the object of his research, even before conducting the research. This involvement is what makes the researcher able to understand the object of his research.
Mechanical interaction of a projectile body with a bore walls of an electromagnetic accelerator. Parametric study
Authors: Plekhanov Alexander Valentinovich , Ryzhov Sergey Yurievich 
Published: December 2024

The vibration of the accelerator rails under the action of electromagnetic forces, the right boundary of which is moving along with the armature along the barrel bore, is considered. The rail accelerator is simply considered as a Bernoulli-Euler beam of finite length, lying on a viscoelastic foundation, with cantilever support from the side of the accelerator breech. The rail vibration is described by a differential equation in partial derivatives of the fourth order in spsce and the second order in time. The equation is solved numerically by combined method: finite differences in time and finite elements in space. The influence of the armature injection velocity and the contact force between the armature and the rails on the rail dynamic behavior, taking into account the friction force, has been studied.	It is shown that an increase in the armature injection velocity reduces the time of action of the armature/rail contact area on the surface of the input part of the accelerator channel, shifts the position of the maximum rail deflection towards the muzzle with its amplitude practically unchanged, and when the armature injection velocity exceeds the critical speed, it leads to a significant decrease in the amplitude of vibrations. In this case, the armature overtakes the leading edge of the vibrations throughout the entire acceleration period. Also, with an increase in the armature injection velocity, the amplitude of the required current decreases and the acceleration time is reduced, which can reduce the mass and dimensions of the electric power source and reduce the requirements for the rail materials due to a decrease in the integral of action, which affects the durability of the materials.	The contact force coefficient m has a complex effect on the amplitude of rail vibrations due to the fact that both the friction force and the magnitude of the repulsive force depend on it. The latter is responsible for a significant increase in the amplitude of vibrations at m > 1. Taking into account the parameter m did not introduce any special features into the vibration process of the rail, as noted in the literature. This is likely due to the fact that more complex processes reflecting non-uniform current distribution analyzed using 3D finite element method cannot be obtained within the beam model.
An Adaptive Ensemble Approach Using Online Global and Local Models for Pump Pressure Prediction in Well Cementing Operations
Authors: Zhong Yuan , Yang Jianxin , Xian Ming , Zhou Jing , Li Ping 
Published: December 2024

Summary
In cementing operations, conventional methods for predicting wellhead pump pressure, which rely on empirical and numerical models, often fall short regarding real-time accuracy and adaptability to different geological blocks and cementing techniques. These shortcomings hinder precise control of the wellhead pressure range, impacting operational safety, efficiency, and on-site personnel guidance. Furthermore, traditional offline machine-learning models cannot handle concept drift due to changing downhole fluid conditions during cementing. This paper frames wellhead pump pressure prediction as an online regression forecasting problem that utilizes the strengths of incremental and online ensemble learning with the Hoeffding tree regressor to overcome these challenges. First, data features are partitioned into subsets to create base learners, and then global and local models are deployed to address concept drift. The dynamic integration of these models significantly improves adaptability and performance. Experimental results confirm the superiority of our method over existing approaches. Compared with the suboptimal online models, mean squared error (MSE) is reduced for pump pressure prediction in five cementing data sets by 74.65%, 75.09%, 59.27%, 65.21%, and 70.01%, respectively. Additionally, MSE is reduced by 52.46%, 51.18%, 42.93%, 57.12%, 56.23%, 64.83%, and 79.51%, respectively, in seven open data sets, which showcases the broad applicability of our method to other regression tasks.
Drug development for rare diseases: a case for patient-centricity, equity, and access to clinical trials.
Authors: Bowen Allison E , Nargundkar Satish 
Published: December 2024

Abstract

Purpose For many patients, clinical trials are often their only treatment option. These patients face significant barriers to participation due to cognitive and physical limitations, geographical barriers, misdiagnosis, and socioeconomic disparities, particularly among minority groups. This paper examines the impact of health equity and patient-centricity on access to clinical trials, explores how addressing these factors enhances outcomes in rare disease research, and outlines best practices for integrating patient voices into the drug development process.Method A two-pronged study was conducted. Group A involved a focus group discussion with 19 subject matter experts (SMEs) in regulation and policies, and members of the healthcare community. Group B consisted of 10 individuals with direct ties to rare diseases. Semi-structured interviews were conducted regarding access, equity, and patient centricity. The purpose of these interviews was to delve deeper into their personal experiences, expectations, and concerns related to clinical trials and treatments.Results Three major impediments to appropriate healthcare for the rare disease population were identified: inconsistent government regulations, insufficient support networks (financial, treatment gaps), and lack of information on rare diseases. Inconsistent policies across the USA, compared to standardized healthcare policies in Canada and other nations, lead to delays in diagnosis and treatment. While emotional support is available, financial and treatment support gaps persist. Additionally, there is a significant information deficit for both patients and physicians. Participants emphasized the importance of including patients and caregivers early in the drug development process to ensure that developed treatments meet their needs.Conclusion This study highlighted the critical role of patient-centricity and health equity in clinical trials, offering strategic insights for improving health equity and integrating the patient’s voice into the drug development process to enhance research effectiveness and inclusivity.
Rhodiola polysaccharides affect the antioxidant capacity and testosterone secretion of PLCs in hypoxia environment through the metabolism of unsaturated fatty acids and glutathione
Authors: Luo Jinting , Wang Lei , Yao Youli , Luo Xuan , Zhang Jianbo , Luo Dandan , Tian Tian , Wu Guofang 
Published: December 2024

Abstract

Hypoxia induces oxidative stress and cellular dysfunction. Rhodiola polysaccharide (RDP), a distinguished bioactive compound of Rhodiola rosea L., demonstrates strong antioxidant activity. Whether the RDP have protective effect on hypoxia injury of porcine Leydig cells (PLCs) merits further investigation. Our research showed that when RDP was introduced to PLCs under hypoxia condition, both the antioxidant capacity and testosterone (T) secretion of PLCs were enhanced. Notably, this treatment revealed a significant correlation between T levels and specific metabolites, suggesting RDP's role in diminishing reactive oxygen species and fortifying antioxidant defenses. Moreover, RDP promoted the synthesis of antioxidant metabolites and modulated pathways involved in unsaturated fatty acids and glutathione metabolism, mitigating oxidative stress. These results suggested that RDP could improve the cellular antioxidant capacity and stimulate T secretion of PLCs in hypoxia environment through multiple pathways.
Real-time non-invasive monitoring of acute pulmonary embolism based on dynamic EIT technology: A new approach
Authors: Li Junyao , Zhu Mingxu , Guo Yitong , Li Weichen , He Qing , Wang Yu , Liu Yuxuan , Liu Benyuan , Liu Yang , Wang Weice , Ji Zhenyu , Shi Xuetao 
Published: December 2024

Abstract

Background
Acute pulmonary embolism is the third most prevalent cardiovascular pathology, following coronary artery disease and hypertension. It is not only frequently misdiagnosed and underdiagnosed, but also carries an untreated mortality rate of 20–30%. In view of the lack of real-time monitoring technology for acute pulmonary embolism, this study investigates the feasibility of using the newly developed high-performance electrical impedance tomography (EIT) system for the detection and real-time monitoring of acute pulmonary embolism through the acquisition and imaging of pulsed pulmonary blood flow signals.
Methods
A total of 12 domestic pigs (20.75 ± 2.56 kg) were used in a before-and-after self-control experiment. The changes in pulmonary perfusion induced before and after acute pulmonary embolism (artificially induced) were monitored in real time by applying the vascular pulsatility method. The Amplitude, Forward (Negative) Slope, and SARC were extracted from the data for the purpose of assessing the status of local pulmonary perfusion. Furthermore, the degree of ventilation/perfusion matching in the lungs was evaluated concurrently with the analysis of lung ventilation areas. A conventional invasive hypertonic saline (5ml of 10% NaCl) contrast technique was employed for the purpose of control validation.
Results
The perfusion alterations subsequent to embolisation via the vascular pulsatile method exhibited a high degree of consistency with those observed following the administration of hypertonic saline. In particular, the perfusion area on the embolised side was markedly diminished, as were the perfusion indexes, with the most pronounced alterations observed in Amplitude (P < 0.001) and SARC (P < 0.001). Furthermore, the extracted V/Q and other indexes, in conjunction with regional ventilation, demonstrated notable discrepancies. The V/Q match% (P < 0.001) and Dead Space% (P < 0.001) exhibited the greatest sensitivity to alterations in acute. Furthermore, a high degree of concordance was observed between the two methods in the detection of acute pulmonary embolism when compared with the hypertonic saline method (Kappa = 0.75, P < 0.05).
Conclusions
The vascular beat-based EIT imaging method has the potential to reflect changes in pulmonary perfusion status before and after embolisation in real time. This could prove to be an effective non-invasive real-time bedside monitoring method for acute pulmonary embolism.
Breast Cancer Screening Rates and Influencing Factors Among LGBTQ Groups in Japan
Authors: Hara Akemi , Ozaki Akihiko , Murakami Michio , Saito Hiroaki , Nashimoto Mika , Hori Daisuke , Tsubokura Masaharu , Gonda Kenji , Wada Masahiro , Tachibana Kazunoshin , Ohtake Tohru , Tabuchi Takahiro 
Published: December 2024

Abstract

Background
Lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals face significant health disparities worldwide, particularly in preventive medicine. In Japan, where breast cancer has the highest incidence rate among women, understanding screening behaviors among LGBTQ individuals is crucial for improving public health outcomes.
Objective
This study aimed to elucidate the relationship between LGBTQ status and breast cancer screening behaviors in Japan, identifying factors influencing screening uptake and highlighting challenges in health management for the LGBTQ community.
Methods
Using data from the Japan COVID-19 and Society Internet Survey (JACSIS), we analyzed breast cancer screening status among 11,056 biological females. Multinomial logistic regression and stratified regression analyzes were employed to examine factors associated with screening behavior, comparing LGBTQ and non-LGBTQ groups.
Results
LGBTQ individuals demonstrated significantly lower odds of undergoing breast cancer screening (OR 0.82, 95% CI 0.73-0.91, p<0.001) compared to non-LGBTQ individuals. Key factors influencing lower screening rates among individuals in the survey were primarily linked to LGBTQ identity, followed by higher rates of being uninsured, unmarried status, lower income levels, alcohol consumption. Stratified analysis revealed that uninsured LGBTQ individuals had significantly lower odds of screening (OR 0.23, 95% CI 0.08-0.70, p=0.01) compared to those with national health insurance.
Conclusion
This study highlights significant disparities in breast cancer screening behaviors between LGBTQ and non-LGBTQ individuals in Japan. Findings underscore the need for targeted interventions, including improved healthcare access, LGBTQ-friendly medical environments, and awareness campaigns to address these disparities and promote health equity within the LGBTQ community.
Temporal evolution of insecticide resistance and bionomics in Anopheles funestus – a key malaria vector in Uganda reveals intricacies in population structure, resistance phenotypes and genetic markers
Authors: Oruni Ambrose , Tchouakui Magellan , Tagne Carlos S. Djoko , Hearn Jack , Kayondo Jonathan , Wondji Charles S. 
Published: December 2024

Abstract

Insecticide resistance escalation is decreasing the efficacy of vector control tools. Monitoring vector resistance is paramount in order to understand its evolution and devise effective counter-solutions. In this study, we monitored insecticide resistance patterns, vector population bionomics and genetic variants associated with resistance over 3 years from 2021 to 2023 in Uganda. Anopheles funestus s.s was the predominant species in Mayuge but with evidence of hybridization with other species of the An. funestus group. Sporozoite infection rates were relatively very high with a peak of 20.41% in March 2022. Intense pyrethroid resistance was seen against pyrethroids up to 10-times the diagnostic concentration but partial recovery of susceptibility in PBO synergistic assays. Among bednets, only PBO-based nets (PermaNet 3.0 Top and Olyset Plus) and chlorfenapyr-based net (Interceptor G2) had high mortality rates. Mosquitoes were fully susceptible to chlorfenapyr and organophosphates, moderately resistant to clothianidin and resistant to carbamates. The allele frequency of key P450, CYP9K1, resistance marker was constantly very high but that for CYP6P9A/b were very low. Interestingly, we report the first detection of resistance alleles for Ace1 gene (RS = ~ 13%) and Rdl gene (RS = ~ 21%, RR = ~ 4%) in Uganda. The qRT-PCR revealed that Cytochrome P450s CYP9K1, CYP6P9A, CYP6P9b, CYP6P5 and CYP6M7 were consistently upregulated while a glutathione-S-transferase gene (GSTE2) showed low expression. Our study shows the complexity of insecticide resistance patterns and underlying mechanisms, hence constant and consistent spatial and temporal monitoring is crucial to rapidly detect changing resistance profiles which is key in informing deployment of counter interventions.
Multifunctional hydrogel based on Chlorella protein: Structure, performance and application in cherry preservation
Authors: Zhao Yanan , Yu Cailing , Zu Xinyu , Liang Yan , Wang Hua 
Published: December 2024

Abstract

This study presents a novel multifunctional gel prepared using Chlorella protein (CP) to extend the shelf life of perishable fruits like cherries. Structural, rheological, and scanning electron microscopy analyses revealed that CP hydrogels possess excellent solid-like properties and a stable porous structure. The water-holding capacity (WHC) improved significantly from 67.11 ± 0.72% to 96.53 ± 0.61% with increasing CP concentration, indicating enhanced WHC. Additionally, the decomposition temperature at 5% weight loss was 150°C, demonstrating good thermal stability. Due to the ionization of -COOH and -NH2 groups, the CP hydrogel showed excellent pH sensitivity, with low dissolution rates in acidic environments (64.97%) and significantly higher rates in alkaline environments (448.50%). Furthermore, the CP hydrogel inhibited the penetration of Staphylococcus aureus and Escherichia coli, with increased resistance at higher CP concentrations. CP-22.5 reduced bacterial counts from 109 to less than 105 CFU. Its DPPH and ABTS•+ radical scavenging capacities were 74.50% and 97.92%, respectively, indicating strong antioxidant properties. In cherries preservation tests, CP hydrogel extended preservation time to 15 days compared to 5 days in the control group, effectively inhibiting decay, suggesting CP hydrogel is a promising choice for multifunctional fruit preservation.