bluuebunny/crossref_metadata_2025_split huggingface dataset:
Welche PatientInnen sind mit dem Ergebnis ihrer sozialmedizinischen Leistungsbeurteilung nicht einverstanden und welche Behandlung brauchen sie?
Authors: Kessemeier Franziska Maria , Bassler Markus , Petermann Franz , Kobelt-Pönicke Axel 
Published: October 2019

Zusammenfassung
Fragestellung Die sozialmedizinische Leistungsbeurteilung ist zentraler Bestandteil des Entlassungsberichts der medizinischen Rehabilitation und stellt die Basis weiterer wichtiger versicherungsrechtlicher Maßnahmen dar. Immer wieder sind PatientInnen mit dem Ergebnis ihrer sozialmedizinischen Leistungsbeurteilung nicht einverstanden. Diese Tatsache verkompliziert häufig den Return to Work. Untersucht wird, ob sich diese Patientengruppen hinsichtlich soziodemografischer Parameter, der Bewertung der therapeutischen Allianz und des Reha-Outcome unterscheiden.
Material und Methoden KlinikmitarbeiterInnen werden dazu angehalten im Entlassungsbericht zu dokumentieren, ob ein Dissens bzgl. der sozialmedizinischen Leistungsbeurteilung vorliegt. Die Entlassungsberichte aller 2014 im Rehazentrum Oberharz behandelten PatientInnen wurden daraufhin gesichtet (n=1178). Mittels Chi-Quadrat-Tests und (multivariaten) Kovarianzanalysen wurden die Patientengruppen hinsichtlich soziodemographischer Parameter, Behandlungszufriedenheit, therapeutischer Allianz und psychosomatischen Veränderungen über die Rehabilitation analysiert.
Ergebnisse PatientInnen im Dissens konnten auf Symptomebene von ihrer Reha-Behandlung weniger profitieren, waren mit dem Ergebnis ihrer Behandlung und mit der Therapeut-Patient-Interaktion unzufriedener.
Diskussion Die sozialmedizinische Leistungsbeurteilung ist ein komplexer Prozess, der sowohl auf Beurteiler- wie auf Patientenseite durch zahlreiche Motive beeinflusst wird. Diese sind nur schwer zu erfassen und statistisch zu berücksichtigen.
Schlussfolgerungen Um durch den Dissens entstehende Komplikationen zu vermeiden, sollten insbesondere bei stark psychosomatisch belasteten PatientInnen mit problematischer Erwerbsbiografie früh berufsbezogene Therapieangebote eingeleitet werden. In der Therapie sozialmedizinisch auffälliger PatientInnen sollte ein besonderer Wert auf eine gute Patient-Therapeut-Passung gelegt werden.
Melanin Production Inhibitors from the West African Cassipourea congoensis
Authors: Takou Dieudonné M. , Waffo Alain F. Kamdem , Langat Moses K. , Wansi Jean D. , Mulcahy-Ryan Lauren E. , Schwikkard Sianne L. , Opara Elizabeth I. , Mas-Claret Eduard , Mulholland Dulcie A. 
Published: October 2019

Abstract
Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6
, (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.
DNVF-Memorandum – Gesundheits- und Medizin-Apps (GuMAs)
Authors: Kramer Ursula , Borges Uirassu , Fischer Florian , Hoffmann Wolfgang , Pobiruchin Monika , Vollmar Horst Christian 
Published: October 2019

ZusammenfassungMit der Nutzung von Gesundheits- und Medizin-Apps sind große Erwartungen an eine Verbesserung der Qualität und Effizienz von Präventions- und Versorgungskonzepten verknüpft. In weiten Bevölkerungsschichten ist die Bereitschaft zur Nutzung groß. Es fehlt jedoch belastbare Evidenz, um ausgehend vom derzeitigen, weitgehend unregulierten Angebot, Bedarf, Qualität und Sicherheit dieser Anwendungen einschätzen zu können. Aus diesem Grund adressiert die AG Digital Health im vorliegenden Memorandum wichtige Fragestellungen wie Angebot, objektiven Bedarf und Nettonutzen von Gesundheits- und Medizin-Apps (GuMAs), ethische Standards, Risiken und GuMAs als Forschungsressource, die von der Versorgungsforschung u. a. durch geeignete methodische Ansätze untersucht und beantwortet werden sollten. Diese Fragestellungen beziehen sich auf die Aspekte Patientensicherheit, Prozess- und Ergebnisqualität, versorgungsrelevante Aspekte digitaler Anwendungen und deren Einsatz in und für die wissenschaftliche Forschung.
The Bonding and Reactivity of α-Carbonyl Cyclopropanes
Authors: Craig Alexander J. , Hawkins Bill C. 
Published: October 2019

The cyclopropane functionality has been exploited in a myriad of settings that range from total synthesis and methodological chemistry, to medical and materials science. While it has been seen in such a breadth of settings, the typical view of the cyclopropane moiety is that its reactivity is derived primarily from the release of ring strain. While this simplified view is a useful shorthand, it ignores the specific nature of cyclopropyl molecular orbitals. This review aims to present the different facets of cyclopropane bonding by examining the main models that have been used to explain the reactivity of the functionality over the years. However, even with advanced theory, being able to precisely predict the reactivity of an exact system is nigh impossible. Specifically chosen, carbonyl-bearing cyclopropyl species act as so-called acceptor cyclopropanes and, if correctly derivatised, donor–acceptor cyclopropanes. By undertaking a case study of the history of carbonyl cyclopropanes in organic synthesis, this review highlights the relationship between the understanding of theory and pattern recognition in developing new synthetic methods and showcases those successful in balancing this critical junction.1	Cyclopropanes2	The Strain Model3	The Forster–Coulsin–Moffit Model4	The Walsh Model5	Acceptor, Donor, and Donor–Acceptor Cyclopropanes6	Reactions of Carbonyl Cyclopropanes
Localización con semilla radioactiva (LSR) de lesiones no palpables de la mama- Desarrollo e implementación del programa en la República Argentina
Authors: Muñoz María Soledad , Rossi Carlos Enrique , Muñoz Marcelo 
Published: October 2019

ResumenEl intervencionismo en mama se inició con la localización preoperatoria de lesiones no palpables.En una segunda etapa, el desarrollo de técnicas de biopsias en las tres modalidades (mamografía, ultrasonido y resonancia magnética), reforzaron las indicaciones de localización de lesiones con histología ya confirmada.La técnica de localización en Argentina se basó casi exclusivamente en la inserción de alambres con arpones e inyección de carbón.A partir del año 2001, se ofreció como alternativa a las localizaciones con arpones la inserción de semilla de Iodo-125, considerando las ventajas para la paciente, el cirujano y el sistema hospitalario al desacoplar los turnos de quirófano y servicios de imágenes, otorgando acceso a cualquier cuadrante con incisiones cosméticas.La provisión del isótopo es la clave para instalar y atender la demanda de los usuarios, una vez que han conocido los méritos del procedimiento.En todos los ámbitos y distintos países, se verificó una lenta incorporación a la rutina de localización de lesiones con material radioactivo, primariamente por las regulaciones fundamentales y justificadas para la adquisición del isótopo.En nuestro medio y en una labor conjunta con la Autoridad Regulatoria Nuclear (ARN), logramos finalmente, en el año 2017, el reconocimiento de la práctica.Revisamos la bibliografía, describimos la técnica y la logística para lograr autorización de aquellos centros interesados en aplicar un procedimiento universalmente adoptado por sus ventajas respecto a los métodos tradicionales.
Implant-Retained Auricular Prosthesis: A Case Report
Authors: Ozturk A Nilgun , Usumez Aslihan , Tosun Zekeriya 
Published: October 2019

ABSTRACTExtraoral implant retained prosthesis have been proven to be a predictable treatment option for maxillofacial rehabilitation. This case report describes the clinical and laboratory procedures for fabricating an auricular prosthesis.In this case report, an auricular prosthesis was fabricated for a patient who lost the left and right external ear in an electrical burn. Extraoral implants and bar-and-clip retention for the proper connection of the auricular prosthesis to implant were used. This prosthesis was acceptable to the patient because of excellent support, retentive abilities and the patient�s appearance. (Eur J Dent 2010;4:71-74)
Surgical Management of Chiari Malformations: Preliminary Results of Surgery According to the Mechanisms of Ptosis of the Brain Stem and Cerebellum
Authors: Nishikawa Misao , Bolognese Paolo A. , Kula Roger W. , Ikuno Hiromichi , Takami Toshihiro , Ohata Kenji 
Published: October 2019

Abstract
Introduction We classified Chiari malformation type I (CM-I) according to the mechanism of ptosis of the brain stem and cerebellum, based on a morphometric study of the posterior cranial fossa (PCF) and craniovertebral junction (CVJ). Surgery was performed to manage the mechanism of the hindbrain ptosis.
Materials and Methods We calculated the volume of the PCF (VPCF) and the area surrounding the foramen magnum (VSFM) and measured the axial length of the enchondral parts of the occipital bone (occipital bone size) and the hindbrain. According to these measures, we classified CM-I into type A (normal VPCF, normal VSFM, and normal occipital bone size), type B (normal VPCF, small VSFM, and small occipital bone size), and type C (small VPCF, small VSFM, and small occipital bone size). Foramen magnum decompression (FMD) (280 cases) was performed on CM-I types A and B. Expansive suboccipital cranioplasty (ESCP) was performed on CM-I type C. Posterior craniocervical fixation (CCF) was performed in cases with CVJ instability. Lysis of the adhesion and/or sectioning of the filum terminale were performed on cases with tethered cord syndrome.
Results Both ESCP and FMD had a high rate of improvement of neurological symptoms (87%) and recovery rate. There was only small number of complications. CCF had a high rate of improvement of neurological symptoms (88%) and joint stabilization.
Conclusion In the management of Chiari malformation, appropriate surgical methods that address ptosis of the hindbrain should be chosen. Each surgical approach resulted in a good improvement of neurological symptoms.
Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study
Authors: Bal Cenkhan , Alacam Alev , Tuzuner Tamer , Tirali Resmiye Ebru , Baris Emre 
Published: October 2019

ABSTRACTObjectives: The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)2 histopathologically. Methods: Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study. Four cavities were prepared in each rat in four quadrants, and each quadrant represented different experimental groups. In Group I: 0.5% sodium hypochlorite (NaOCl); in Group II: 2% chlorhexidine digluconate (CHX); in Group III: 0.1% octenidine dihydrochloride (OCT); and in Group IV 0.9% sterile saline was applied to the exposure site with a sterile cotton pellet for 3 minutes. After hemorrhage control, the pulps were capped with hard setting Ca(OH)2 and, finally, restored with IRM. The animals were euthanized at 21 days post-operatively. After sacrificing, routine histological procedures were performed and evaluated statistically with non-parametric Kruskal-Wallis test among the groups and two-by-two comparisons by using the Mann-Whitney U test for inflammatory response and tissue organization scores at the confidence interval of 95%. Results: There were significant differences in inflammatory response and tissue organization scores between the groups (P<.05). Statistical evaluation of inflammatory response showed that Group IV was significantly different from Groups I, II and III separately with a higher inflammatory cell response (P<.05) whereas no significant differences were detected between the other groups in two-by-two comparisons (P>.05). Healthy coronal and radicular pulp tissue organization scores indicated that the Group I has better pulp tissue organization than Group IV and this was significantly different (P<.05) whereas no significant differences were observed between the other groups separately (P>.05). Conclusions: The antiseptic materials used in this study created an environment that, rather than saline solution, may affect clinical and histological success in a positive way. (Eur J Dent 2011;5:265-272)
Comparison of Depth of Cure, Hardness and Heat Generation of LED and High Intensity QTH Light Sources
Authors: Mousavinasab Sayed Mostafa , Meyers Ian 
Published: October 2019

ABSTRACTObjectives: To compare curing performance of a second generation LED curing light with a high power tungsten quartz halogen (QTH). Methods: A hybrid composite resin (Filtek Z 250, 3M, USA) was used as test material and cured using a second generation LED light (Translux Power BlueTM, Heraus Kulzer ,Germany) or a very high power QTH light unit (EMS, Switzerland). A two split aluminum mold was used to prepare ten samples with LED light source cured for forty seconds and ten samples prepared using high power QTH light unit, cured for four or six seconds recommended exposure time. Hardness, depth of cure (DOC) and thermal rise during exposure time by these light sources were measured. The data submitted to analysis of variance (ANOVA), Tukey's and student's t tests at 5% significance level. Results: Significant differences were found in hardness, DOC of samples cured by above mentioned light sources and also in thermal rises during exposure time. The curing performance of the tested QTH was not as well as the LED light. TPB light source produced the maximum hardness (81.25, 73.29, 65.49,55.83 and 24.53 for 0 mm, 1 mm, 2 mm, 3 mm and 4 mm intervals) and DOC (2.64 mm) values with forty seconds irradiation time and the high power (QTH) the least hardness (73.27, 61.51 and 31.59 for 0 mm, 1 mm and 2 mm, respectively) and DOC (2 mm) values with four seconds irradiation time.Thermal rises during 4 s and 6 s curing time using high power QTH and tested LED were 1.88˚C, 3˚C and 1.87˚C, respectively. Conclusions: The used high power LED light produced greater hardness and depth of cure during forty seconds exposure time compared to high power QTH light with four or six seconds curing time. Thermal rise during 6 s curing time with QTH was greater compared to thermal changes occurred during 40 s curing time with tested LED light source. There was no difference seen in thermal changes caused by LED light with 40 s and QTH light with 4 s exposure time. (Eur J Dent 2011;5:299- 304)
Evaluation of oral health status and salivary flow rate in obese patients after bariatric surgery
Authors: Marsicano Juliane A , Sales-Peres Arsenio , Ceneviva Reginaldo , Sales-Peres Silvia H de C 
Published: October 2019

ABSTRACTObjectives: The aim of this study was to identify the prevalence of dental caries, periodontal diseases and tooth wear in bariatric patients, and relate the oral health conditions to saliva flow.Methods: Fifty-two patients who had undergone bariatric surgery (Roux-en-Y gastric bypass) and 50 severely obese patients indicated for bariatric surgery were submitted to clinical examinations with regard to dental caries (DMFT index), periodontal condition (CPI index), dental wear (DWI index – Dental wear index) and saliva flow. The data were statistically analyzed by the Student’s-t , Mann- Whitney, Spearman Correlation and Chi-square (χ2) tests at 5% significance level.Results: The DMFT index was 16.11±5.19 in the surgical group and 16.06±6.29 in the control group (P>.05). The mean CPI was 3.05±0.84 for the operated group and 2.66±1.25 for the obese patients with no significant difference between them (P>.05). There was statistically significant difference between the groups for the presence of periodontal pockets (P=.021). All the patients presented some degree of tooth wear, however, with no significant difference between the two groups (P=.82). The mean saliva flow values of the surgical group and control group were 0.64±0.46 mL/min and 0.66±0.49 mL/min, respectively. There was no significant difference in saliva flow and all oral conditions analyzed (P>.05).Conclusion: The prevalence of oral diseases was similar in severely obese patients who were candidates for bariatric surgery and in patients who had been submitted to bariatric surgery. Nevertheless, there was higher prevalence of periodontal pockets in the operated group. (Eur J Dent 2012;6:191-197)
IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies
Authors: Volkó Julianna , Kenesei Ádám , Zhang Meili , Várnai Péter , Mocsár Gábor , Petrus Michael N. , Jambrovics Károly , Balajthy Zoltán , Müller Gabriele , Bodnár Andrea , Tóth Katalin , Waldmann Thomas A. , Vámosi György 
Published: October 2019

SignificanceInterleukin-2 (IL-2), a cytokine produced by activated T cells, acting in a paracrine/autocrine fashion, is essential for T cell proliferation. In adult T cell leukemia (ATL) and in autoimmune/graft-vs.-host diseases, anti–IL-2Rα antibody therapies were established to inhibit proliferation, with only limited success. We demonstrated that IL-2/15 receptors start to assemble in the endoplasmic reticulum/Golgi and demonstrated signaling by Jak1/Jak3 in the Golgi. Thus, in T cells also producing IL-2 (e.g., ATL cells), signaling can already take place before receptors reach cell membranes. This scenario explains resistance to antibody therapies targeting receptors at cell surfaces. Our study sheds light on an autocrine signaling mechanism, in which an intracellularly synthesized ligand activates its receptor en route toward the cell surface.
Distinct representations of spatial and categorical relationships across human scene-selective cortex
Authors: Persichetti Andrew S. , Dilks Daniel D. 
Published: October 2019

SignificanceHumans are capable of many sophisticated behaviors. One such behavior is using landmarks to navigate from one place to another, distant place. This type of navigation, known as landmark-based navigation, requires the navigator to extract spatial information from places in the environment. Another sophisticated behavior is recognizing the type of place one is in and acting appropriately in that environment (e.g., recognizing that you are in a kitchen, and thus making a cup of coffee). This type of behavior does not rely on spatial information so much as it relies on extracting cues related to the category membership of different places. Here we show that these complex interactions with our environment, navigating between places and recognizing them, are neurally dissociable.
Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds
Authors: Woodcock Mark E. , Gheyas Almas A. , Mason Andrew S. , Nandi Sunil , Taylor Lorna , Sherman Adrian , Smith Jacqueline , Burt Dave W. , Hawken Rachel , McGrew Michael J. 
Published: October 2019

Significance
In the fields of conservation biology and sustainable agriculture, the ability to cryopreserve and revive animal species is paramount to efforts to preserve genetic diversity. An innovative approach is to use sterile surrogate host animals for the transplantation of reproductive germ cells from rare/endangered animals. This technology has previously been utilized in mammals but is of particular importance for animals with lipid-filled zygotes/embryos, such as fish and birds, which render cryopreservation techniques inefficient. We demonstrate that the female chicken rendered sterile using genome editing technology can be used as a surrogate host for transplanted cryopreserved germ cells and only lay eggs of the transplanted rare chicken breed. Our results suggest a way to preserve the biodiversity of bird species.
KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines
Authors: Manville Rían W. , van der Horst Jennifer , Redford Kaitlyn E. , Katz Benjamin B. , Jepps Thomas A. , Abbott Geoffrey W. 
Published: October 2019

SignificanceBotanical folk medicines have been used by diverse human populations and cultures for several millennia. Many are still in use today, but the underlying molecular mechanisms often remain elusive. Here we report the discovery of a molecular mechanism linking diverse plant extracts used traditionally to lower blood pressure (hypotensives). All of the hypotensive plants tested activated the KCNQ5 vascular-expressed potassium channel, whereas nonhypotensives did not. For one hypotensive plant, we describe discovery of the active small molecule (aloperine) and demonstrate that it KCNQ-dependently relaxes blood vessels. The discovery opens up a new source of potential therapeutic drugs and explains the mechanism behind folk hypotensive medicines used by diverse populations for thousands of years.
Waterproof molecular monolayers stabilize 2D materials
Authors: Su Cong , Yin Zongyou , Yan Qing-Bo , Wang Zegao , Lin Hongtao , Sun Lei , Xu Wenshuo , Yamada Tetsuya , Ji Xiang , Zettsu Nobuyuki , Teshima Katsuya , Warner Jamie H. , Dincă Mircea , Hu Juejun , Dong Mingdong , Su Gang , Kong Jing , Li Ju 
Published: October 2019

Significance
A family of strong yet removable 1- to 2-nm-thick ultrathin monolayer is developed as a corrosion inhibitor for 2-dimensional materials that significantly prolong lifetime while protecting optoelectronic properties in both ambient and harsh chemical or thermal environments. This method is low in toxicity and can be applied to arbitrary substrate with no size limit.
β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea
Authors: Jansson Lina , Ebeid Michael , Shen Jessica W. , Mokhtari Tara E. , Quiruz Lee A. , Ornitz David M. , Huh Sung-Ho , Cheng Alan G. 
Published: October 2019

SignificanceThe cochlea is essential for sound detection. It consists of highly differentiated hair cells and nonsensory supporting cells radially patterned into lateral and medial compartments. However, mechanisms regulating radial patterning and specification of hair cell and supporting cell subtypes, each of which serves unique functions, are unclear. Here we show that β-catenin is required for radial patterning and differentiation of sensory and nonsensory cell subtypes in the developing cochlea. β-Catenin-deleted cochleae displayed disrupted compartment borders containing ectopic hair cell and supporting cell subtypes, whereas inhibiting transcriptional and preserving cell adhesion-mediated activities of β-catenin maintained radial patterning and cell identity. This study thus characterizes a role for β-catenin-mediated cell adhesion in the developing cochlea.
Recalibrating categorisation
Authors: Praet Helena Van 
Published: October 2019

AbstractThis article explores how the notion of decreation manifests itself in the signifying strategies of Anne Carson’sDecreation: Poetry, Essays, Opera(2005). By revisiting Carson’s stereoscopic poetics and Wolfgang Iser’s branch of reader-response criticism, the article conceptualises these signification strategies, which include generic hybridity and multimodality, as guiding devices that usher the reader’s perspective towards a stereoscopic vision of sameness-in-otherness. These strategies can evoke a sense of ‘decreation’ by drawing the reader’s attention to the boundary between (apparent) incongruities whilst simultaneously encouraging the reader to forge previously unsuspected connections. The semiological argument proposed here concludes that the transcendence of this ‘edge’ by means of analogical thinking constitutes the metaphysical project of personal re-creation.