bluuebunny/crossref_metadata_2025_split huggingface dataset:
AimB is a small protein regulator of cell size and MreB assembly
Authors: Werner John N. , Shi Handuo , Hsin Jen , Huang Kerwyn Casey , Gitai Zemer , Klein Eric A. 
Published: May 2019

AbstractThe MreB actin-like cytoskeleton assembles into dynamic polymers that coordinate cell shape in many bacteria. In contrast to most other cytoskeletons, few MreB interacting proteins have been well characterized. Here we identify a small protein fromCaulobacter crescentus, AimB, as anAssemblyInhibitor ofMreB. AimB overexpression mimics inhibition of MreB polymerization, leading to increased cell width and MreB delocalization. Molecular dynamics simulations suggest that AimB binds MreB at its monomer-monomer protofilament interaction cleft. We validate this model through functional analysis of point mutants in both AimB and MreB, photo-crosslinking studies with site-specific unnatural amino acids, and species-specific activity of AimB. Together, our findings indicate that AimB promotes MreB dynamics by inhibiting monomer-monomer assembly interactions, representing a new mechanism for regulating actin-like polymers and the first identification of a non-toxin MreB assembly inhibitor.
Dissecting the economic impact of soybean diseases in the United States over two decades
Authors: Bandara Ananda Y. , Weerasooriya Dilooshi K. , Bradley Carl A. , Allen Tom W. , Esker Paul D. 
Published: May 2019

ABSTRACTSoybean (Glycine maxL. Merrill) is a key commodity for United States agriculture. Here we analyze the economic impacts of 23 common soybean diseases in 28 soybean-producing states in the U.S., from 1996 to 2016. From 1996 to 2016, the total estimated economic loss due to soybean diseases in the U.S. was $81.39 billion, with $68.98 billion and $12.41 billion accounting for the northern and southern U.S. losses, respectively. Across states and years, soybean cyst nematode, charcoal rot, and seedling diseases were the most economically damaging pathogens/diseases while soybean rust, bacterial blight, and southern blight were the least economically damaging. Significantly positive linear correlation of mean soybean yield loss with the mean state-wide soybean production (MT) and mean soybean yield (kg ha−1) indicated that high production zones are more vulnerable to soybean diseases-associated yield losses. Our findings provide useful insights into how research, policy, and educational efforts should be prioritized in soybean disease management.
Sex chromosome evolution in muscid flies
Authors: Meisel Richard P. , Olafson Pia U. , Adhikari Kiran , Guerrero Felix D. , Konganti Kranti , Benoit Joshua B. 
Published: May 2019

AbstractSex chromosomes and sex determining genes can evolve fast, with the sex-linked chromosomes often differing between closely related species. A substantial body of population genetics theory has been developed and tested to explain the rapid evolution of sex chromosomes and sex determination. However, we do not know why the sex-linked chromosomes differ between some species pairs yet are relatively conserved in other taxa. Addressing this question will require comparing closely related taxa with conserved and divergent sex chromosomes and sex determination systems to identify biological features that could explain these rate differences. Cytological karyotypes suggest that muscid flies (e.g., house fly) and blow flies are such a taxonomic pair. The sex chromosomes appear to differ across muscid species, whereas they are highly conserved across blow flies. Despite the cytological evidence, we do not know the extent to which muscid sex chromosomes are independently derived along different evolutionary lineages. To address that question, we used genomic data to identify young sex chromosomes in two closely related muscid species, horn fly (Haematobia irritans) and stable fly (Stomoxys calcitrans). We provide evidence that the nascent sex chromosomes of horn fly and stable fly were derived independently from each other and from the young sex chromosomes of the closely related house fly (Musca domestica). We present three different scenarios that could have given rise to the sex chromosomes of horn fly and stable fly, and we describe how the scenarios could be distinguished. Distinguishing between these scenarios in future work could help to identify features of muscid genomes that promote sex chromosome divergence.
Bi-directional Mendelian randomization of epithelial ovarian cancer and schizophrenia and uni-directional Mendelian randomization of schizophrenia on circulating glycerophosphocholine metabolites
Authors: Adams Charleen D. , Neuhausen Susan L. 
Published: May 2019

ABSTRACTMost women with epithelial ovarian cancer (EOC) present with late-stage disease. As a result, globally, EOC is responsible for more than 150,000 deaths a year. Thus, a better understanding of risk factors for developing EOC is crucial for earlier screening and detection to improve survival. To that effort, there have been suggestions that there is an association of schizophrenia and cancer, possibly because metabolic changes are a hallmark of both cancer and schizophrenia (SZ). Perturbed choline metabolism has been documented in both diseases. Our objective was to use Mendelian randomization to evaluate whether SZ increased risk for developing EOC or the converse, and, whether SZ impacted glycerophosphocholine (GPC) metabolites. We found that SZ conferred a weak but increased risk for EOC, but not the reverse (no evidence that EOC caused SZ). SZ was also causally associated with lower levels of two GPC species and with suggestively lower levels in an additional three GPCs. We postulate that perturbed choline metabolism in SZ may mimic or contribute to a “cholinic” phenotype, as observed in EOC cells.
A nanometer difference in myofilament lattice spacing of two cockroach leg muscles explains their different functions
Authors: Tune Travis Carver , Ma Weikang , Irving Thomas C. , Sponberg Simon 
Published: May 2019

AbstractMuscle is highly organized across scales. Consequently, small changes in arrangement of myofilaments can influence macroscopic function. Two leg muscles of a cockroach, have identical innervation, mass, twitch responses, length-tension curves, and force-velocity relationships. However, during running, one muscle is dissipative, while the other produces significant positive mechanical work. Using time resolved x-ray diffraction in intact, contracting muscle, we simultaneously measured the myofilament lattice spacing, packing structure, and macroscopic force production of these muscle to test if nanoscale differences could account for this conundrum. While the packing patterns are the same, one muscle has 1 nm smaller lattice spacing at rest. Under isometric activation, the difference in lattice spacing disappeared explaining the two muscles’ identical steady state behavior. During periodic contractions, one muscle undergoes a 1 nm greater change in lattice spacing, which correlates with force. This is the first identified feature that can account for the muscles’ different functions.
Aspirin compliance for cardiovascular disease and colorectal cancer prevention in the uninsured population
Authors: Liu Nina , Mathews Adithya , Swanson Justin , Mhaskar Rahul , Mathews Akshay , Ayoubi Noura , Mirza Abu-Sayeef 
Published: May 2019

AbstractAspirin is an effective anti-inflammatory and antiplatelet agent as an irreversible inhibitor of cyclooxygenase. In 2016, the U.S. Preventive Services Task Force recommended aspirin for primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC) in patients aged 50 to 69 with a 10% or greater 10-year CVD risk. Due to the lack of literature describing compliance with these recommendations in the uninsured patient population, we studied the aspirin adherence for CVD and CRC prevention in several free medical clinics. We investigated the records of 8857 uninsured patients who visited nine free medical clinics in the Tampa Bay Area in 2016-2017. Aspirin compliance was assessed for patients with prior myocardial infarction (MI) or coronary artery disease (CAD). 54% (n=1467) of patients met the criteria to take aspirin for primary prevention of CVD and CRC, but just 17% of these patients aged 50-59 were on the medication. 16% percent of patients aged 60-69 were taking aspirin and significantly more men than women were on aspirin (p=0.025). Of the 306 patients who had prior MI or CAD, 50% were on the medication for secondary prevention. Among the uninsured population, there is low compliance with recommendations for aspirin usage to reduce the risk of CVD and CRC. This study demonstrates that further improvements are needed to increase adherence to current guidelines and address barriers uninsured patients may face in maintaining their cardiovascular and colorectal health.
Lactic Acid Containing Polymers Produced in EngineeredSinorhizobium melilotiandPseudomonas putida
Authors: Tran Tam T. , Charles Trevor C. 
Published: May 2019

AbstractThis study demonstrates that novel polymer production can be achieved by introducing pTAM, a broad-host-range plasmid expressing codon-optimized genes encodingClostridium propionicumpropionate CoA transferase (PctCp) and a modifiedPseudomonassp. MBEL 6-19 polyhydroxyalkanoate (PHA) synthase 1 (PhaC1Ps6-19), intophaCmutant strains of the native polymer producersSinorhizobium melilotiandPseudomonas putida. Both phenotypic analysis and gas chromatography analysis indicated the synthesis and accumulation of biopolymers inS. melilotiandP. putidastrains. Expression inS. melilotiresulted in the production of PLA homopolymer up to 3.2% dried cell weight (DCW). The quaterpolymer P(3HB-co-LA-co-3HHx-co-3HO) was produced by expression inP. putida. TheP. putida phaCmutant strain produced this type of polymer the most efficiently with polymer content of 42% DCW when cultured in defined media with the addition of sodium octanoate, while the greatest LA fraction (4% mol) was achieved in the same strain cultured in LB with the addition of lactic acid. This is the first report, to our knowledge, of the production of a range of different biopolymers using the same plasmid-based system in different backgrounds. In addition, it is the first time that the novel polymer (P(3HB-co-LA-co-3HHx-co-3HO)), has been reported being produced in bacteria.
Rhythmicity of health information behaviour
Authors: Tana Jonas , Eirola Emil , Eriksson-Backa Kristina 
Published: May 2019

PurposeThis paper brings focus and attention to the aspect of time within health information behaviour. The purpose of this paper is to critically assess and present strengths and weaknesses of utilising the infodemiology approach and metrics as a novel way to examine temporal variations and patterns of online health information behaviour. The approach is shortly exemplified by presenting empirical evidence for temporal patterns of health information behaviour on different time-scales.Design/methodology/approachA short review of online health information behaviour is presented and methodological barriers to studying the temporal nature of this behaviour are emphasised. To exemplify how the infodemiology approach and metrics can be utilised to examine temporal patterns, and to test the hypothesis of existing rhythmicity of health information behaviour, a brief analysis of longitudinal data from a large discussion forum is analysed.FindingsClear evidence of robust temporal patterns and variations of online health information behaviour are shown. The paper highlights that focussing on time and the question of when people engage in health information behaviour can have significant consequences.Practical implicationsStudying temporal patterns and trends for health information behaviour can help in creating optimal interventions and health promotion campaigns at optimal times. This can be highly beneficial for positive health outcomes.Originality/valueA new methodological approach to study online health information behaviour from a temporal perspective, a phenomenon that has previously been neglected, is presented. Providing evidence for rhythmicity can complement existing epidemiological data for a more holistic picture of health and diseases, and their behavioural aspects.
What does Google recommend when you want to compare insurance offerings?
Authors: Lewandowski Dirk , Sünkler Sebastian 
Published: May 2019

Purpose
The purpose of this paper is to describe a new method to improve the analysis of search engine results by considering the provider level as well as the domain level. This approach is tested by conducting a study using queries on the topic of insurance comparisons.

Design/methodology/approach
The authors conducted an empirical study that analyses the results of search queries aimed at comparing insurance companies. The authors used a self-developed software system that automatically queries commercial search engines and automatically extracts the content of the returned result pages for further data analysis. The data analysis was carried out using the KNIME Analytics Platform.

Findings
Google’s top search results are served by only a few providers that frequently appear in these results. The authors show that some providers operate several domains on the same topic and that these domains appear for the same queries in the result lists.

Research limitations/implications
The authors demonstrate the feasibility of this approach and draw conclusions for further investigations from the empirical study. However, the study is a limited use case based on a limited number of search queries.

Originality/value
The proposed method allows large-scale analysis of the composition of the top results from commercial search engines. It allows using valid empirical data to determine what users actually see on the search engine result pages.
Towards task-sensitive assistance in public spaces
Authors: Kilian Melanie A. , Kattenbeck Markus , Ferstl Matthias , Ludwig Bernd , Alt Florian 
Published: May 2019

Purpose
Performing tasks in public spaces can be demanding due to task complexity. Systems that can keep track of the current task state may help their users to successfully fulfill a task. These systems, however, require major implementation effort. The purpose of this paper is to investigate if and how a mobile information assistant which has only basic task-tracking capabilities can support users by employing a least effort approach. This means, we are interested in whether such a system is able to have an impact on the way a workflow in public space is perceived.

Design/methodology/approach
The authors implement and test AIRBOT, a mobile chatbot application that can assist air passengers in successfully boarding a plane. The authors apply a three-tier approach and, first, conduct expert and passenger interviews to understand the workflow and the information needs occurring therein; second, the authors implement a mobile chatbot application providing minimum task-tracking capabilities to support travelers by providing boarding-relevant information in a proactive manner. Finally, the authors evaluate this application by means of an in situ study (n = 101 passengers) at a major European airport.

Findings
The authors provide evidence that basic task-tracking capabilities are sufficient to affect the users’ task perception. AIRBOT is able to decrease the perceived workload airport services impose on users. It has a negative impact on satisfaction with non-personalized information offered by the airport, though.

Originality/value
The study shows that the number of features is not the most important means to successfully provide assistance in public space workflows. The study can, moreover, serve as a blueprint to design task-based assistants for other contexts.
Semantic preserving bijective mappings for expressions involving special functions between computer algebra systems and document preparation systems
Authors: Greiner-Petter André , Schubotz Moritz , Cohl Howard S. , Gipp Bela 
Published: May 2019

Purpose
Modern mathematicians and scientists of math-related disciplines often use Document Preparation Systems (DPS) to write and Computer Algebra Systems (CAS) to calculate mathematical expressions. Usually, they translate the expressions manually between DPS and CAS. This process is time-consuming and error-prone. The purpose of this paper is to automate this translation. This paper uses Maple and Mathematica as the CAS, and LaTeX as the DPS.

Design/methodology/approach
Bruce Miller at the National Institute of Standards and Technology (NIST) developed a collection of special LaTeX macros that create links from mathematical symbols to their definitions in the NIST Digital Library of Mathematical Functions (DLMF). The authors are using these macros to perform rule-based translations between the formulae in the DLMF and CAS. Moreover, the authors develop software to ease the creation of new rules and to discover inconsistencies.

Findings
The authors created 396 mappings and translated 58.8 percent of DLMF formulae (2,405 expressions) successfully between Maple and DLMF. For a significant percentage, the special function definitions in Maple and the DLMF were different. An atomic symbol in one system maps to a composite expression in the other system. The translator was also successfully used for automatic verification of mathematical online compendia and CAS. The evaluation techniques discovered two errors in the DLMF and one defect in Maple.

Originality/value
This paper introduces the first translation tool for special functions between LaTeX and CAS. The approach improves error-prone manual translations and can be used to verify mathematical online compendia and CAS.
Assessing supplier capabilities to exploit building information modelling
Authors: Wang Yingli , Gosling Jonathan , Naim Mohamed M. 
Published: May 2019

Purpose
A number of governments are making building information modeling (BIM) a mandatory requirement for all public works construction projects. While main contractors may be ready to comply with such requirements, the supply chain as whole may be vulnerable as lower-tier suppliers may not be able to adopt BIM. There is currently no objective approach to assessing BIM maturity; hence, this paper aims to develop a new approach to determine suppliers’ current vision and execution-based capabilities to exploit BIM and their capacity to reach a higher maturity level.

Design/methodology/approach
Based on UK Government BIM maturity levels, the authors exploit a unique data set made available by a main contractor, to determine a data-driven approach, using K-means, to assess the capabilities and vision of its supply base.

Findings
The authors find a direct comparison between our suggested K-means clusters and the UK Government’s BIM maturity levels. However, in interrogating specific cases, the authors find that using a subjective approach would have wrongly categorized certain companies. The authors also determine what capability and strategic developments are required for companies to move to a higher level.

Research limitations/implications
The method aligns with the existing UK BIM maturity model and enhances the model by determining the likelihood of a supplier in progressing to a higher level of maturity. The research was with a single case company, exploiting their existing survey instrument and data. A more comprehensive study could be adopted with a generic survey questionnaire.

Practical implications
The research may be exploited by companies to take a strategic approach to assess suppliers in BIM adoption and to establish supplier development mechanisms.

Originality/value
The data-driven approach avoids ambiguity of categories and mis-categorizing suppliers.
Prioritizing marketing research in virtual reality: development of an immersion/fantasy typology
Authors: Cowan Kirsten , Ketron Seth 
Published: May 2019

PurposeVirtual reality (VR) is of increasing interest to marketers because it can be used to explore and proactively shape long-term futures, co-create value with consumers, and foster consumer-brand engagement. Yet, to date, the field lacks a cohesive framework for approaching VR research; thus, the objective of this systematic literature review is to provide such a framework and highlight research opportunities.Design/methodology/approachFirst, after conducting a systematic literature review, we highlight VR themes instrumental to flow and propose a typology for VR research using realism-fantasy and immersion as dimensions. Next, we review the current state of empirical research for each quadrant. Finally, we synthesize research within each quadrant, specifying criteria and considerations for conducting research. In doing so, we propose an agenda for marketing research, centered on methodological, future studies, and consumer-related contributions.FindingsVR themes instrumental to flow include the avatar, application quality, and interactivity. We find, contrary to some conceptualizations of VR, that all applications are capable of producing flow. Conflicting research and gaps are highlighted in the findings section and summarized in Table III. Additionally, while prior research seems to draw from findings of other VR applications in advancing knowledge in general, the results of the literature review suggest that VR applications should be treated uniquely. Finally, we propose highly immersive VR applications as more conducive to future studies research.Research limitations/implicationsScholars can utilize the findings to prioritize future research studies in marketing. By following the typology and research opportunities, scholars can advance marketing theory and enhance the external validity of research studies through VR applications.Practical implicationsManagers can utilize the findings to ascertain consumers and societies‘ responses to various marketing stimuli, with implications for product development, branding, retail/service experiences, adoption of new technologies, tourism, and many other domains. VR applications offer managers more ways of testing concepts and processes in realistic fashion without the costs and risks associated with more traditional methods.Originality/valueThe objective of this paper is to examine varying opportunities for VR research given flow and fantasy potential and to prioritize VR research.
An integrated understanding of librarian professional identity
Authors: Pierson Cameron M. , Goulding Anne , Campbell-Meier Jennifer 
Published: May 2019

PurposeThe purpose of this paper is to review literature on librarian professional identity to develop a more integrated understanding of this topic.Design/methodology/approachLiterature was retrieved and analysed with no date or geographic limit from nine databases on the subject of librarian professional identity. A combination of keywords and database specific controlled language was utilized to increase retrieval, as well as inspection of reference lists. Exclusion criteria were applied.FindingsThe review found 14 characteristics or themes relevant to librarian professional identity formation and development, understood as process over time. This process is in part defined by benchmark events, such as critical incidents, as well as highly personal aspects, such as perception of these incidents. This review also introduces an original conceptual model of librarian professional identity formation and development.Research limitations/implicationsA limitation of this review was that only English-language literature was considered. A further limitation is the omission of works that have not been formally published. Additionally, the model introduced is untested.Originality/valueBy reviewing librarian professional identity literature, this paper offers an integrated understanding of this topic and introduces a new, original model to understand the process of librarian professional identity and development. It further offers an examination based on a sociological lens to examine this identity.