bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal serum procalcitonin levels in prediction of chorioamnionitis in women with preterm premature rupture of membranes
Authors: Bakar Rabia Zehra , Köroğlu Nadiye , Turkgeldi Lale S. , Tola Esra N. , Cetin Berna Aslan , Gedikbasi Ali 
Published: August 2019

IntroductionChorioamnionitis is one of the most important maternal complications in the expectant management of patients with preterm premature rupture of membranes (PPROM). Procalcitonin (proCT), the precursor of the hormone calcitonin, is used to differentiate bacterial infections from non-bacterial ones. The objective of the study was to determine the efficacy of maternal serum procalcitonin levels in the early prediction of chorioamnionitis in women with PPROM.Material and methodsThe study was conducted in 76 pregnant women hospitalized due to PPROM at the maternal-fetal medicine unit of a tertiary center in Istanbul. Patients were followed up with white blood cell (WBC), C-reactive protein (CRP) and proCT levels every 2 days. The values of investigated parameters were recorded at the diagnosis of PPROM and at the time of delivery. The maximum values during the follow-up period were also recorded.ResultsOut of the 76 patients with PPROM, 15 (19.73%) developed clinical chorioamnionitis. No significant difference could be detected in the gravidity, parity, duration of hospitalization and gestational week at diagnosis between those patients who developed clinical chorioamnionitis and those who did not. The WBC at the time of hospital admittance and before delivery, and CRP levels before delivery were statistically higher in the chorioamnionitis group (p < 0.05). No difference in the proCT levels could be detected either at the time of hospital admittance or before delivery between the two groups.ConclusionsMaternal proCT was not found to be predictive of chorioamnionitis. However, since there are reports in the literature that contradict these results, further studies are warranted to determine the true efficacy of proCT in the prediction of clinical chorioamnionitis.
Thymoquinone activates imidazoline receptor to enhance glucagon-like peptide-1 secretion in diabetic rats
Authors: Lee Shu Ping , Kuo Feng Yu , Cheng Juei-Tang , Wu Ming Chang 
Published: August 2019

IntroductionThymoquinone (TQ) is one of the principal bioactive ingredients proven to exhibit anti-diabetic effects. Recently, glucagon-like peptide-1 (GLP-1) has been found to be involved in antidiabetic effects in rats. The aim of this study was to evaluate the mediation of GLP-1 in the antidiabetic effect of TQ and to understand the possible mechanisms.Material and methodsNCI-H716 cells and CHO-K1 cells were used to investigate the effects of TQ on GLP-1 secretion in vitro. In type 1 diabetic rats, the changes in plasma glucose and GLP-1 levels were evaluated with TQ treatment.ResultsThe direct effect of TQ on imidazoline receptors (I-Rs) was identified in CHO-K1 cells overexpressing I-Rs. Additionally, in the intestinal NCI-H716 cells that may secrete GLP-1, TQ treatment enhanced GLP-1 secretion in a dose-dependent manner. However, these effects of TQ were reduced by ablation of I-Rs with siRNA in NCI-H716 cells. Moreover, these effects were inhibited by BU224, the imidazoline I2 receptor (I-2R) antagonist. In diabetic rats, TQ increased plasma GLP-1 levels, which were inhibited by BU-224 treatment. Functionally, TQ-attenuated hyperglycemia is also evidenced through GLP-1 using pharmacological manipulations.ConclusionsThis report demonstrates that TQ may promote GLP-1 secretion through I-R activation to reduce hyperglycemia in type-1 diabetic rats.
Evaluation of selected balance indices on the stabilometric platform in children after mild head trauma
Authors: Niedzielski Jerzy K. , Kaczmarek Michał 
Published: August 2019

IntroductionThe aim of the study was to investigate the occurrence of balance disorders in children after mild head trauma.Material and methodsNinety patients after mild head trauma, aged 7–18 years, were examined on a stabilometric platform 48 h and 12 weeks after injury. The results were compared with 50 healthy children. Seven selected parameters of the stabilogram were measured and analyzed.ResultsChildren hospitalized after head trauma represented 3.78% of all surgical admissions and 6.6% of all patients after head trauma reporting to the emergency department. The values of all parameters in the entire study group 48 hours after injury were significantly higher than 12 weeks later (p < 0.03), when they decreased to the level of the values in the controls. An inverse relationship between the value of each parameter and the child’s age, both in the study group 48 h after injury (p < 0.014) and in the controls (p < 0.008), was found. The values of all parameters in children of the study group aged 11–15 years 48 h after the injury were significantly higher than 12 weeks later (p < 0.05), and significantly higher than in the controls (p < 0.05). The best indicators describing disorders and normalization of body balance control processes were the total path length of center of pressure (SP-EO), the average center of pressure deflection (MA-EO) and the average center of pressure sagittal deflection (MAAP-EO).ConclusionsMinor head trauma clearly, though temporarily, disturbed body postural control, especially affecting children aged 11-15. However, all examined patients 3 months after injury controlled the body balance, like their healthy peers.
IL-35, TNF-α, BAFF, and VEGF serum levels in patients
with different rheumatic diseases
Authors: Wojdasiewicz Piotr , Wajda Anna , Haładyj Ewa , Romanowska-Próchnicka Katarzyna , Felis-Giemza Anna , Nałęcz-Janik Jolanta , Walczyk Marcela , Olesińska Marzena , Tarnacka Beata , Paradowska-Gorycka Agnieszka 
Published: August 2019

ObjectivesInflammatory processes in rheumatic diseases spread via various types of immune system cells and tissues with the aid of inflammatory cytokines and growth factors and the participation of vascular endothelium. Research is still conducted to determine the role of individual factors in the pathophysiology of rheumatic diseases. The task is complicated because the multiplane network of cytokines is characterized by complex correlations manifesting as positive and negative feedback, which impedes the definitive interpretation of the role of specific cytokines. Therefore, it seems justified to perform a comparative analysis of the expression of at least several molecules in one study, which may help reveal their role in the pathogenesis of rheumatic diseases and have prognostic value.Material and methodsThe aim of the study involves the assessment and comparative analysis of the concentrations of interleukin 35 (IL-35), tumour necrosis factor  (TNF-), B-cell-activating factor (BAFF), and vascular endothelial growth factor (VEGF) in peripheral blood serum in patients with rheumatoid arthritis (RA) (n = 43), systemic lupus erythematosus (SLE) (n = 28), antiphospholipid syndrome (APS) (n = 24), and mixed connective tissue disease (MCTD) (n = 9). The main intention is to search for biomarkers for specific rheumatic diseases. Cytokine and growth factor levels were determined using specific ELISA kits.ResultsStatistically significant differences in VEGF and IL-35 concentrations occurred between patients with APS vs. RA and SLE vs. RA. There was a significant high positive correlation between the concentration of BAFF and TNF- (r = 0.77, p < 0.0000) in patients with APS, as well as in patients with SLE (r = 0.55, p = 0.00).ConclusionsBAFF and TNF- may be promising biomarkers in patients with APS and VEGF in patients with RA. Additionally, IL-35 may be a useful marker for the diagnosis of APS. Positive correlation of BAFF and TNF- concentrations in APS and SLE potentially indicates much more similar etiopathogenesis of these diseases than it could be previously predicted.
Lack of Effect of Oral Melatonin on Platelet Parameters in Normal Healthy Dogs
Authors: Chen Melody , Stone Richard 
Published: August 2019

ABSTRACTA randomized, prospective, blinded, placebo-controlled study on the effect of oral melatonin on platelet parameters was performed on 40 healthy dogs with normal physical examinations and no clinically significant findings on serum chemistry evaluation. Dogs were randomly assigned to the study group or the placebo-control group and administered oral melatonin or an oral inert tablet, respectively, for 28 days. Dogs in the study group were administered melatonin at 3 mg per os q 12 hr for dogs weighing &lt;15 kg and 6 mg per os q 12 hr for dogs weighing 15 kg or more. Complete blood counts were obtained at 0, 7, 14, and 28 days of medication administration. No adverse effects or sedation were noted in any dog. The placebo group had a statistically significant transient increase in both plateletcrit and mean platelet volume on day 7 relative to baseline, which was not observed in the melatonin group. Oral melatonin did not appear to have a direct thrombopoietic effect in normal healthy dogs. Future studies are required to investigate the pharmacokinetics of melatonin in dogs and the potential benefits of melatonin in both thrombocytopenia and immune-mediated diseases.
Hydropulsion as Palliative, Long-Term, Last-Resort Treatment of Nasal Carcinoma in a Dog and a Cat
Authors: Bienes Tom , Robin Elisabeth , Le Boedec Kevin 
Published: August 2019

ABSTRACTAn 8 yr old spayed female domestic shorthair and an 8 yr old neutered male Polish Lowland sheepdog were evaluated for a 3 wk history of sneezing and a 5 day history of left epistaxis, respectively. In both cases, computed tomography revealed a voluminous nasal mass, which was later histologically identified as carcinoma, without cribriform plate involvement. Nasal hydropulsion was performed in both animals in sternal recumbency under general anesthesia. A Poole suction tip was inserted into the orad esophageal opening and adequacy of the endotracheal tube cuff inflation was checked. Sterile saline was forcefully infused into the obstructed nasal cavity to dislodge the tumor. Both patients had temporary resolution of clinical signs. Nasal hydropulsion was repeated as a palliative last-resort treatment at each clinical relapse (four times in both animals over ≥1 yr), allowing long-term survival. Minor complications included a self-limiting retrobulbar and oropharyngeal swelling in the cat and self-limiting epistaxis in both animals. Although this technique is not intended to represent an equivalent alternative to radiation or surgical therapies, nasal hydropulsion may represent an appropriate palliative, last-resort treatment in case of obstructive nasal tumors in dogs and cats, when radiation therapy or surgery is not affordable, available, or desired.
The Function of the Short Medial Collateral Ligaments of the Canine Tarsus: A Cadaveric Study
Authors: Bogisch Sandra , Schuenemann Riccarda 
Published: August 2019

ABSTRACT
Information on the clinical behavior of cases with an isolated rupture of the short collateral ligaments of the canine tarsus is sparse. Our objective was to evaluate the function of the short medial collateral ligaments (SMCLs) in 90° flexion. Eight cadaveric limbs were tested for internal/external rotation and valgus/varus before and after transection of one or both SMCLs. In one group, the tibiocentral ligament was transected first, followed by the tibiotalar. In the second group, the order of transection was reversed. Angular changes between two k-wires were measured and compared. Internal rotation increased significantly after transection of one or both SMCLs (P = .015 and P = .004), with higher angular changes in the group in which the tibiotalar ligament was transected first (P = .003). Transection of this ligament alone was sufficient to cause caudomedial subluxation upon internal rotation. Valgus angulation increased after transection of one ligament (P = .022), but there was also an increase in varus angulation after transection of both ligaments (P = .027). Unlike the long medial collateral ligament, which stabilizes against deviation toward lateral, the SMCL stabilizes against subluxation toward medial, with the tibiotalar ligament being the major stabilizer in flexion. Findings can be used as diagnostic guidance for isolated tarsal short collateral ligament injuries.
FITOTERÁPICOS NA ATENÇÃO BÁSICA À SAÚDE: UMA EXPERIÊNCIA NA REGIÃO SUL DO BRASIL
Authors: GRIBNER Caroline , RATTMANN Yanna Dantas , GOMES Eliane Carneiro 
Published: August 2019

O uso da fitoterapia e plantas medicinais na terapia humana é uma das práticas terapêuticas mais antigas da humanidade, apresentando origem tanto do conhecimento popular como das experiências científicas. Os fitoterápicos constam na Relação Nacional de Medicamentos Essenciais compondo o grupo do componente básico da assistência farmacêutica estando disponíveis para aquisição e dispensação aos usuários do Sistema Único de Saúde. Neste contexto, buscou-se verificar a utilização de Fitoterápicos Industrializados na Atenção Básica à Saúde nos municípios da Região Metropolitana de Curitiba, a fim de avaliar quais possuem fitoterápicos industrializados como alternativa terapêutica, bem como quais são disponibilizados pelos municípios. Os dados foram obtidos por meio de consulta à Relação Municipal de Medicamentos Essenciais, além de informações provenientes das secretarias municipais de saúde de cada município que compõem a Região Metropolitana de Curitiba. Dos 29 municípios da Região Metropolitana de Curitiba, 23 dispensam fitoterápicos industrializados, sendo que 6 municípios optam por não disponibilizá-los. Entre os fitoterápicos dispensados, 4 deles se mostram mais frequentes. São eles: Xarope de Guaco (87%), Isoflavona de Soja (48%), Ginkgo biloba (30%) e Espinheira Santa (22%). Quando avaliada a diversidade dos fitoterápicos, observou-se que, em média, os municípios possuem em seu elenco 1 ou 3 fitoterápicos industrializados. Conclui-se que a maioria dos municípios da Região Metropolitana de Curitiba opta por utilizar fitoterápicos como alternativa de tratamento, e que, embora ocorram várias ações no sentido de implementar os fitoterápicos no Sistema Único de Saúde, esse crescimento ainda não foi suficiente para torná-los uma unanimidade nos serviços de saúde.
PRODUÇÃO E AVALIAÇÃO NUTRICIONAL DE FARINHA DE MOYASHI - BROTO DE FEIJÃO MUNGO-VERDE (Vigna radiata, Fabaceae).
Authors: SILVA J. M. H. M. , MAIA M. E. P. , BERGMANN M. F. , BRUSKE M. , ROCHA M. C. , GIOVANETTI R. X. , CARVALHO T. P. , BALBI M. E. 
Published: August 2019

A Vigna radiata (L.) Wilczek popularmente conhecida como mungo-verde ou feijão-moyashi é um membro da família das leguminosas Fabaceae. Esta leguminosa é de fácil adaptação nos climas tropicais e subtropicais, sendo utilizada principalmente como suplemento proteico em diferentes pratos utilizando a farinha ou a leguminosa bruta, devido suas fontes de minerais, vitaminas, proteínas e baixas calorias o que o tornou popular no Brasil pela procura de alimentação saudável. Neste sentido, o objetivo do trabalho foi realizar uma avaliação química e nutricional do broto de feijão-moyashi e da farinha produzida a partir dele. Para isso o alimento adquirido da Chácara Paraíso, passou inicialmente por uma análise macroscópica e foi submetido a várias determinações como: umidade, proteínas, lipídios, fibras e minerais, obtendo os seguintes resultados: 94,89%, 1,31%, 0,038%, 1,46% e 0,266%, respectivamente para o broto de feijão e 16,10%, 25,82%, 0,74%, 28,51% e 5,20%, para a farinha. Os dados de carboidratos foram obtido por diferença, 2,03% para o broto de feijão e 23,63% para a farinha. A partir dos dados obtidos comparou-se os resultados com os estabelecidos pela tabela TACO, e ainda com outras farinhas comerciais. Os valores nutricionais encontrados para o broto de feijão se mostraram próximos aos valores estabelecidos. Já a farinha do broto de feijão-moyashi se destacou pela grande quantidade de proteínas, baixo teor lipídico e grande quantidade de fibras, sendo assim, uma opção saudável para indivíduos veganos e vegetarianos por ser muito nutritiva e economicamente acessível.
AREND, SILVIA MARIA F.; MOURA, ESMERALDA B. B. DE; SOSENSKI, SUSANA. (ORGS.). INFÂNCIAS E JUVENTUDES NO SÉCULO XX: HISTÓRIAS LATINO-AMERICANAS. PONTA GROSSA: TODAPALAVRA, 2018. 368P.
Authors: Vieira Chirley Beatriz da Silva , Silva Otoniel Rodrigues 
Published: August 2019

Resenha do livro organizado pelas historiadoras Esmeralda Blanco B. de Moira, Silvia Maria Fávero Arend e Susana Sosenski. As autoras apresentam estudos realizados por historiadores na área das Ciências Humanas e Sociais, especificamente na área da História da Infância e da Juventude nos países latinoamericanos. A temática, segundo as autoras, está presente em vários países da América Latina, sucitando discussões que possibilitam um maior engajamento entre os países latinos.
PLANO MESTRE PARA DEFINIÇÃO E NIVELAMENTO DA DEMANDA FÁBRIL
Authors: De Sousa Alexandre Aparecido , Viagi Arcione Ferreira 
Published: August 2019

A correta administração entre planejar e executar planos de produção devem estar pautados em premissas técnicas de conhecimento de PPCP, uma vez que prazos de entregas e capacidades de produção são previamente definidas, e nem sempre possuem um alinhamento entre a necessidade de demanda e a capacidade de execução. Neste contexto o trabalho propõe a implantação de um plano mestre de produção para definição e nivelamento da demanda fabril em uma indústria de autopeças, com utilização de um sistema ERP. Desta forma, o objetivo geral da pesquisa é que através da implantação de um plano mestre de produção reduza-se a ocorrência de setup, melhore o controle de inventário e nivelamento da produção, uma vez que o mesmo deve considerar a melhor configuração para a produção, assim como definição de infraestrutura e mão de obra necessárias. Com isso a pesquisa visa demonstrar o comprometimento com a satisfação de seus clientes e o as operações, não perdendo de foco premissas como nivelamento de produção, controle de inventário e redução de setups, apresentando de forma clara a aplicação do plano mestre de produção e como ele pode auxiliar na transformação de planos produtivos de longo prazo de produtos acabados para o prazo mediano, com intuito de dirigir as etapas de planejamento operacional da empresa.
RESENHA - CRENÇAS E REFLEXÕES SOBRE AS TDICS NA PRÁTICA DOCENTE DE PROFESSORES DE LÍNGUAS ADICIONAIS
Authors: Silva Rickison Cristiano de Araújo 
Published: August 2019

Resenha do livro: SOUZA, Fábio Marques de; SANTOS, Geyza de Freitas. VELHAS PRÁTICAS EM NOVOS SUPORTES? Crenças e reflexões a respeito das Tecnologias Digitais da Informação e Comunicação (TDICS) como mediadoras do complexo processo de ensino-aprendizagem de línguas. 1. ed. Rio de Janeiro: Oficina da Leitura, 2018. v. 1. 108p.
Evaluation of the Levels of Heavy Metals, Total Petroleum Hydrocarbon and Total Hydrocarbon Content in Tympanotomus fuscatus and Sediment, Qua Iboe River, Akwa Ibom State, Nigeria
Authors: E. Ikpe Edidiong , O. Ekwere Ifiok , G. Ukpong Etiowo , O. Effiong James , E. Okon Okon 
Published: August 2019

This study assesses the levels of heavy metals and hydrocarbons in Tympanotomus fuscatus and the sediments of Qua Iboe River, Akwa Ibom State; the interest in the study area was due to the several industrial and oil exploration activities in the area. The heavy metals (HM) of interest were Pb, Cd, Cu, Se, Zn, As, Cr, Fe, Ni and Hg, determined using Atomic Absorption Spectroscopy while Total Hydrocarbon Content (THC) and Total Petroleum Hydrocarbon (TPH) were determined by the GC-FID method. Results obtained indicated that the heavy metal concentration in Tympanotomus fuscatus ranged as follows: Pb (1.037 – 2.002 mg/kg), Cd (0.00 – 0.088 mg/kg), Cu (0.0037 – 10.01 mg/kg), Se (2.364 – 5.063 mg/kg), Zn (0.025 – 1.393 mg/kg), As (0.0113 – 0.355 mg/kg), Cr (1.075 – 3.055 mg/kg), Fe (2.384 – 10.022), Ni (0.045 – 1.223 mg/kg), Hg (0.037 – 1.003 mg/kg) while heavy metal concentration in sediments were: Pb (1.399 – 2.345 mg/kg), Cd (0.0267– 0.222 mg/kg), Cu (0.017 – 10.0197 mg/kg), Se (1.388 – 3.369 mg/kg), Zn (5.688 – 8.038 mg/kg), As (0.003 – 0.0317 mg/kg), Cr (0.0157 – 2.057 mg/kg), Fe (27.351 – 86.686), Ni (0.017 – 5.0413 mg/kg), Hg (0.06 – 1.53 mg/kg); generally, heavy metals levels were higher in dry season than in wet season. The levels of TPH ranged from 160.86 – 1081.52 mg/kg in Tympanotomus fuscatus and 175.97 – 3143.91 mg/kg in sediments; meanwhile, the concentration of TPH ranged from 728.47 – 2442.04 mg/kg in Tympanotomus fuscatus and 492.41 – 7186.25 mg/kg in sediments. Multiple correlation coefficient matrixes were carried out to ascertain the relationship between the pollutants concentration in the biota and sediments. Furthermore, predictive modeling of pollutant concentration in flesh and shell of Tympanotomus fuscatus was estimated. The results indicate that the amounts of HM, TPH and THC in some of the study sites were above the maximum permissible limit set by WHO and FMEnv; thus, pose health risk to humans.
Use of Tedizolid for the Treatment of Staphylococcus aureus Bacteremia – An off Labelled Indication
Authors: Loo L. W. , Kwa Andrea L. , Low Jenny G. , Chien Jaime 
Published: August 2019

Aims: We aim to share our experience in the successful use of tedizolid for the treatment of Staphylococcus aureus bacteremia in two of our patients.
Presentation of Cases: Our first patient had methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. The MRSA isolated was sensitive to linezolid and vancomycin (MIC=2), resistant to daptomycin (MIC=2). In view of the documented drug allergy to ceftriaxone and drug interaction with daptomycin, the patient was initially initiated on intravenous vancomycin but developed a breakthrough fever with rising inflammatory markers. However, upon initiation of tedizolid, fever lysed and the patient improved clinically.
Our second patient has end–stage renal failure on hemodialysis. The patient has methicillin-susceptible Staphylococcus aureus (MSSA) catheter-related bloodstream infection. The MSSA isolated was sensitive to vancomycin (MIC=2) and ceftaroline (MIC=0.50), but resistant to daptomycin (MIC=2). Vancomycin was initiated in view of documented drug allergy to ceftriaxone but repeated blood cultures showed the persistence of MSSA. Antibiotics were switched to linezolid for 3 days before switching to tedizolid due to previous neutropenia with linezolid. Blood cultures had documented clearance with tedizolid.
Discussion and Conclusion: In both our patients, tedizolid was introduced after a few days of vancomycin therapy. Hence, the efficacy of tedizolid as the first-line therapy for the treatment of staphylococcus bacteremia remains unknown. Nevertheless, in both patients, there was no relapse of staphylococcus bacteremia when tedizolid was used to complete the antibiotic therapy. The optimal treatment duration of staphylococcus bacteremia with tedizolid also remains unknown.