bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medullary Thyroid Cancer with Paraganglioma-Like Pattern Diagnosed During Pregnancy: A Case Report and Literature Revision
Authors: De Tullio Anna , Lisco Giuseppe , Duda Loren , Renzulli Giuseppina , Triggiani Vincenzo 
Published: August 2019

Introduction:
Medullary thyroid carcinoma (MTC) is an infrequent thyroid malignancy
rarely observed and managed during pregnancy. An accurate diagnostic workup is extremely important
in this clinical setting to correctly diagnose and treat the disease, avoiding both maternal and fetal complications.

Objective:
We report our experience in managing an MTC incidentally diagnosed during pregnancy in
a 28-year female, highlighting critical aspects through the diagnostic workup. Additionally, we provide
a literature revision searching on PubMed terms related to “medullary thyroid carcinoma”, “primary
thyroid paraganglioma”, “paraganglioma-like medullary thyroid cancer” in relationship with a nodular
appearance at neck US, serum CT measurement, cytological and histological findings.

Methods:
Specimens for cytological evaluation were stained with the Papanicolaou method while tissue
sections were stained with hematoxylin and eosin and Congo red stain. Immunohistochemical
evaluation was also performed for thyroid transcription factor-1, enolase, thyroglobulin, cytokeratin,
chromogranin A, S-100 protein, glial fibrillary acidic protein, calcitonin and Ki-67.

Results:
Serum CT was incidentally found to be elevated in two consecutive venous samples. However,
the cytological assessment of the fine needle aspiration (FNAc) showed “cells with round-shaped
nuclei and granular chromatin, organized to form nests or syncytial flaps, scattered among histocytes,
and immunocytochemical positivity for CT, thyroid transcriptional factor-1, cytokeratin, S-100 protein”,
highlighting a suspicion of both MTC and intrathyroidal paraganglioma. MTC was finally supposed
after the evidence of a really elevated CT (3,726 pg/ml) measurement in the FNA washout fluid.
After a careful discussion about both risks and benefits, the patient decided to postpone the surgery
after the delivery.

Conclusion:
The histological diagnosis finally confirmed a rare case of paraganglioma-like MTC (T1
N0 Mx), emphasizing the complexity of our differential diagnosis, between an MTC and a thyroidal
paraganglioma. In similar cases, due to a relevant impact on surgical timing, patients should be adequately
informed about both risk and benefits of the surgery during pregnancy, and a careful management
of the disease is required until and after surgery.
Evaluation of Gene Expression and In Vitro Enzyme Study for Antiaging Effect of Crocin and Lutein
Authors: Naik Archana A. , Gadgoli Chhaya H. , Naik Arvind B. 
Published: August 2019

Background:
Tubular calyx of flowers of Nyctanthes arbour-tristis contains an apocarotenoid
crocin, a major constituent present in saffron stigma. The flowers of N. arbortristis are readily
available, hence can be an economic substitute for saffron. Lutein from flowers of Tagetes patula, is
another carotenoid which is a popular antioxidant.

Objective:
Oxidative stress is a major contributor to the process of aging. Carotenoids are powerful
antioxidants. Hence, the study was carried out to evaluate anticollagenase activity and antielastase
activity using gene expression study in Human dermal fibroblasts.

Methods:
Crocin was isolated from the tubular calyx of Nyctanthes arbortristis using flash chromatographic
technique and lutein was isolated using column chromatography. Anticollagenase and antielastase
activity of crocin and lutein were carried out using collagenase from Clostridium
histolyticum as enzyme and porcine pancreatic elastase. Cytotoxicity of crocin and lutein was determined
in Human Dermal Fibroblast cell line (HDF) through MTT assay. In gene expression study,
the HDF Cell line was inoculated with Crocin (450 and 250 ppm) and lutein (100 and 50 ppm) separately
for 24 hrs and the m-RNA expression levels of COL Type-1 and elastin were determined using
RT-PCR. The results were compared with standards.

Result:
Crocin and lutein both showed inhibition of collagenase and elastase enzyme which are responsible
for aging process. The cytotoxic concentration CTC 50 (ppm) for Crocin and lutein was
found to be 790.2 ppm and 137.14 ppm. Gene expression study on crocin rich extract of Nyctanthes
arbortristis showed upregulation of both collagen and elastin gene whereas lutein rich extract having
concentration100 μg/ml showed up regulation by 0.02 fold and concentration 50 μg/ml showed
down regulation.

Conclusion:
In vitro collagenase and elastase enzyme study and Gene expression study showed that
these carotenoids are potential antiageing agents which can be substituted to synthetic cosmeceuticals
as well as saffron.
Sertraline Associated with REM Sleep Behavior Disorder: A Case Report
Authors: Mansouripour Seyed Mostafa , Kumar Dharmendra 
Published: August 2019

Background:
REM sleep behavior disorder (RBD) is manifested by abnormal
motor behavior with an endurance of tone during REM sleep. Studies suggest that patients
taking Selective serotonin reuptake inhibitors (SSRIs) are at greater risk of developing
REM sleep behavior disorder.

Case Presentation:
We present a case of 39-year-old female with a past medical history of
spinal cord injury from a gunshot wound 19 years ago resulting in paraplegia, posttraumatic
stress disorder(PTSD), chronic pain, and chronic sleep problem. After sertraline
started and up-titrated to 200 mg for her anxiety, she noticed worsening of her nighttime
sleep behavior. Her mother also witnessed sleepwalking episode and doing things which
the patient had no recollection in the morning, including trying to take a bath and eat from
the refrigerator. On her follow-up appointment, her sertraline was discontinued altogether
and she was started on Escitalopram 5 mg. She tolerated the medication well, it helped
moderately with her anxiety and by the time of this case report (approximately 1 month)
patient did not report any sleep-related behavior.

Conclusion:
Since antidepressant medication is very commonly prescribed, it is important
to be cautious of physiologic changes they may induce, even if the clinical significance of
these changes is not fully elucidated. In addition, RBD may predict neurodegenerative disorders
a couple of years earlier, so it may be used as an effective early marker of neurodegenerative
diseases.
Solid Lipid Nanoparticles of Dronedarone Hydrochloride for Oral Delivery: Optimization, In Vivo Pharmacokinetics and Uptake Studies
Authors: Gambhire Vaishali M. , Gambhire Makarand S. , Ranpise Nisharani S. 
Published: August 2019

Background:
Dronedarone HCl (DRD), owing to its poor aqueous solubility
and extensive presystemic metabolism shows low oral bioavailability of about 4% without
food, which increases to approximately 15% when administered with a high fat meal.

Objective:
Solid lipid nanoparticles (SLN) were designed with glyceryl monstearate
(GMS) in order to improve oral bioavailability of DRD.

Methods:
Hot homogenization followed by probe sonication was used to prepare SLN dispersions.
Box-Behnken design was used to optimize manufacturing conditions. SLN were
characterized for particle size, zeta potential, entrapment efficiency, physical state and in
vitro drug release. Pharmacokinetics and intestinal uptake study of dronedarone HCl loaded
solid lipid nanoparticles (DRD-SLN) in the presence and absence of endocytic uptake
inhibitor, chlorpromazine (CPZ) was performed with conscious male Wistar rats.

Results:
Optimized formulation of SLN showed particle size of 233 ± 42 nm and entrapment
efficiency of 87.4 ± 1.29%. Results of pharmacokinetic studies revealed enhancement
of bioavailability of DRD by 2.68 folds from SLN as compared to DRD suspension. Significantly
reduced bioavailability of DRD-SLNs in the presence of chlorpromazine,
demonstrated the role of endocytosis in uptake of SLN formulation.

Conclusion:
These results indicated that dronedarone HCl loaded SLN could potentially
be exploited as a delivery system for improving oral bioavailability by minimizing first
pass metabolism.
Formulation and Pharmacokinetic Evaluation of Phosal Based Zaltoprofen Solid Self-Nanoemulsifying Drug Delivery System
Authors: Kalamkar Rajan , Wadher Shailesh 
Published: August 2019

Background:
Phosal based excipients are liquid concentrates containing phospholipids.
They are used to solubilize water-insoluble drug and also act as an emulsifier to
get the smallest droplet size of the formed emulsion after administration.

Objective:
The aim is to prepare phosal based self nanoemulsifying drug delivery system
(SNEDDS) for water insoluble drug zaltoprofen.

Methods:
The various parameters like solubility of drug in different vehicles, ternary phase
diagram are considered to formulate the stable emulsion which is further characterized by
Self emulsification time and globule size analysis to optimize liquid SNEDDS of Zaltoprofen.
Optimized L-SNEDDS was converted into free-flowing powder Solid-SNEDDS
(S-SNEDDS). S-SNEDDS was evaluated for Globule size analysis after reconstitution, in
vitro dissolution study and in vivo pharmacokinetic study in rats.

Results:
Phosal 53 MCT with highest drug solubility was used as oil along with Tween 80
and PEG 400 as surfactant and cosurfactant respectively to prepare liquid SNEDDS. Neusilin
us2 was used as an adsorbent to get free-flowing S-SNEDDS. S-SNEDDS showed
improved dissolution profile of the drug as compared to pure drug. In vivo study demonstrated
that there is a significant increase in Cmax and AUC of S-SNEDDS compared to
zaltoprofen powder.

Conclusion:
Phosal based SNEDDS formation can be successfully used to improve the
dissolution and oral bioavailability of poorly soluble drug zaltoprofen.
Teoria de autodeterminação utilizada em mundos virtuais, um estudo de caso.
Authors: Santiago Sgobbi Fabiana , Margarida Rockenbach Tarouco Liane 
Published: August 2019

Esta pesquisa investigou o impacto da combinação de mundos virtuais 3D comdispositivos móveis, agentes conversacionais e sensor de movimentação, como elementos capazes de promover a motivação de sujeitos envolvidos em um programa de controle de obesidade, fator de alta relevância uma vez que o tratamento personalizado tem alto custo e a obesidade é um problema mundial. Este conjunto de tecnologias foi utilizado como estratégia de apoio com vistas a oferecer ao usuário a sensação de “estar presente” num contexto especialmente preparado para promover a motivação e aprendizagem com a interação com objetos 3D. Este traz um recorte sobre a teoria da autodeterminação e como pode ser trabalhada com os dispositivos de Internet das coisas e agentes conversacionais em mundo virtuais.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE PICTURE AND PICTURE UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR PADA MATA PELAJARAN TIK DI SMP NEGERI 3 SERIRIT
Authors: Ariana Komang Mas , Agustini Ketut , Sindu I Gede Partha 
Published: August 2019

Penelitian ini bertujuan untuk menganalisis peningkatan motivasi dan hasil belajar siswa pada mata pelajaran TIK kelas VIII B semester ganjil 2017/2018 di SMP Negeri 3 Seririt melalui penerapan model pembelajaran kooperatif tipe Picture and Picture. Jenis penelitian merupakan penelitian tindakan kelas. Subjek penelitian adalah siswa kelas VIII B sebanyak 30 orang siswa. Objek penelitian adalah model pembelajaran kooperatif tipe Picture and Picture, motivasi dan hasil belajar. Penelitian ini dilaksanakan dalam dua siklus. Data motivasi belajar dikumpulkan dengan angket dan data hasil belajar dikumpulkan dengan tes. Data penelitian dianalisis secara deskriptif. Hasil analisis data menunjukkan 1) motivasi belajar siklus I dan II berada pada kategori positif. 2) Hasil belajar siswa pada siklus I berada pada kategori sedang, dan pada siklus II berada pada kategori baik. Penerapan model pembelajaran kooperatif tipe Picture and Picture dapat meningkatkan motivasi dan hasil belajar siswa kelas VIII B tahun pelajaran 2017/2018.
FILM DOKUMENTER SENI LUKIS WAYANG KAMASAN KLUNGKUNG BALI
Authors: Pranata I Kadek Evry , Sindu I Gede Partha , Putrama I Made 
Published: August 2019

Penelitian ini bertujuan untuk (1) menghasilkan rancangan dan mengimplementasikan hasil rancangan pengembangan Film Dokumenter Seni Lukis Wayang Kamasan. (2) mengetahui respon masyarakat Bali khususnya masyarakat Desa Kamasan terhadap hasil akhir Film Dokumenter Seni Lukis Wayang Kamasan. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian dan pengembangan dengan model cyclic strategy. Film dokumenter ini diimplementasikan dengan menggunakan aplikasi Adobe Premiere Pro CC 2018 dalam proses video editing, Adobe After Effects CC 2018 untuk pembuatan video animasi, Adobe Audition CC 2018 dalam proses sound editing, serta Adobe Photoshop CC 2018 untuk pembuatan desain keperluan film dokumenter.Hasil penelitian menunjukkan bahwa Film Dokumenter Seni Lukis Wayang Kamasan Klungkung Bali berdasarkan uji ahli isi, dan uji ahli film dokumenter memperoleh rata-rata persentase yaitu 97.16% dengan tingkat pencapaian “Sangat Baik”. Uji respon penonton untuk film dokumenter ini rata-rata persentase yaitu 91.18% dengan tingkat pencapaian “Baik”. Kesimpulan yang didapatkan yaitu Film Dokumenter Seni Lukis Wayang Kamasan Klungkung Bali sudah sangat baik dan bisa digunakan sebagai media informasi sejarah seni lukis wayang kamasan.
PENGEMBANGAN GAME EDUKASI MOBILE MAKHLUK HIDUP KELAS REPTILIA UNTUK SISWA SMP
Authors: Rizalni Risya Listya , Trisnadoli Anggy , Zul Muhammad Ihsan 
Published: August 2019

Kelas reptilia merupakan bagian dari materi klasifikasi makhluk hidup yang terdapat pada mata pelajaran Biologi untuk siswa-siswi SMP kelas VII. Dalam proses belajar mengajar, media pembelajaran merupakan salah satu unsur terpenting selain metode pembelajaran. Manfaat media pembelajaran adalah melancarkan interaksi antara guru dengan siswa sehingga kegiatan pembelajaran akan lebih efektif dan efisien. Penyampaian materi pelajaran ini masih menggunakan sistem tradisional, sehingga kreativitas siswa kurang berkembang. Selain itu, untuk memahami ciri-ciri hewan kelas reptilia hanya dilihat dari gambar yang ada pada buku pelajaran. dan siswa sering mendapatkan nilai buruk bahkan harus melakukan remedial pada materi pelajaran tersebut. Oleh karena itu, dibangun sebuah game edukasi dengan tampilan model hewan 3D untuk pembelajaran materi klasifikasi makhluk hidup kelas reptilia. Berdasarkan pengujian manfaat belajar yang telah dilakukan ke siswa SMP kelas VII, didapatkan bahwa siswa yang menggunakan aplikasi game mengalami peningkatan pemahaman sebesar 40.5%. Pada pengujian fungsional, didapatkan bahwa fungsi pada aplikasi dapat berjalan sesuai dengan hasil yang diharapkan. Serta berdasarkan pengujian umpan balik pengguna dapat disimpulkan bahwa game edukasi ini dapat membantu siswa dalam memahami materi perbedaan makhluk hidup berdasarkan ciri-ciri makhluk hidup kelas reptilia.
FITUR EYE PROTECTION PADA LAYAR SMARTPHONE DAPAT MENGURANGI KELELAHAN MATA DAN MEMPERPANJANG DURASI PENGGUNAANNYA PADA SISWA SMP NEGERI 1 SERIRIT
Authors: Citrawathi Desak Made , Udiantari I. A. I. , Warpala S. W. 
Published: August 2019

Penelitian ini bertujuan untuk mengetahui: (1) fitur eye protection pada layar smartphone dapat mengurangi kelelahan mata; dan (2) fitur eye protection pada layar smartphone dapat meningkatkan durasi penggunaan smartphone. Jenis Penelitian ini adalah penelitian eksperimental semu(quasi experimental) dengan rancangan randomize pre and post test design. Lokasi penelitian di SMP Negeri 1 Seririt Kecamatan Seririt, Kabupaten Buleleng-Bali. Pengambilan sampel dilakukan secara acak dan diambil sebanyak 26siswa. Analisis data dilakukan dengan menggunakan uji t paired dengan taraf signifikansi 5 %. Hasil penelitian ini menunjukkan bahwa ada perbedaan bermakna pada kelelahan mata sebesar 67,81 % (p < 0,05) dan durasi penggunaan smartphone sebesar 56,30 %Â (p < 0,05) antara layar smartphone yang tidak menggunakan fitur eye protection dan yang menggunakan fitur eye protection. Disimpulkan bahwa penggunaan fitur eye protectionpada layar smartphone dapat menurunkan kelelahan mata dan meningkatkan durasi penggunaan. Disarankan agar para pengguna perangkat digital selalu memperhatikan kesehatan dan keselamatan kerja, salah satunya dengan cara mengaktifkan fitur eye protection pada layar smartphone untuk menghindari terjadinya kelelahan mata dan juga dapat memperpanjang durasi penggunaannya.
Pemanfaatan Drone DJI Phantom 4 Untuk Identifikasi Batas Administrasi Wilayah
Authors: Suciani Ayu , Rahmadi M Taufik 
Published: August 2019

Pemanfaatan UAV (Unmanned Aerial Vehicle) atau drone hingga saat ini telah banyak digunakan antara lain untuk monitoring tata ruang kota, identifikasi perubahan lingkungan, konstruksi bangunan, industri, pemetaan perikanan, lahan, kehutanan, tata ruang, hingga pemetaan batas wilayah administrasi. Batas wilayah administrasi merupakan batas atau garis khayal yang hanya terdapat pada peta dan tidak ada di lapangan sesuai dengan ketentuan hukum yang berlaku. Penelitian ini bertujuan untuk menguji tingkat ketelitian hasil foto drone untuk batas administrasi wilayah. Penelitian ini menggunakan metode interpretasi manual. Penelitian ini dilakukan di sebagian wilayah administratif Kota Langsa, yaitu Kelurahan Sidodadi, Kelurahan Serambi, dan Kelurahan Mulia. Pemilihan wilayah kajian ini disebabkan oleh beberapa faktor seperti kepadatan permukiman, pertumbuhan pembangunan yang cepat, dan tingkat kepadatan penduduk yang tinggi. Foto udara perekaman drone pada penelitian ini memiliki resolusi spasial 0.5 meter, sehingga memberikan kenampakan objek yang jelas dan detail.Kata Kunci: Pemetaan, Administrasi, Drone DJI Phantom 4Utilization of UAV (Unmanned Aerial Vehicle) or drone has been widely used in urban spatial monitoring, identification of environmental changes, building construction, industry, fishery mapping, land, forestry, spatial planning, and mapping administrative boundaries. The administrative boundary is an imaginary line that only available in the map but not exactly exist on earth based on applicable law. The aim of this study is to examine the accuracy of the photo result of the DJI Phantom 4 for regional administrative boundaries. This study uses manual interpretation methods. This research was conducted in some villages of Langsa City, they are; Sidodadi, Serambi, and Mulia. The region selection is based on several factors such as settlement density, rapid development growth, and high population. The aerial photos of drone recording in this study has a spatial resolution 0.5 meters, so that give the clear appearance and detailed object.Keyword: Mapping, Administration, Drone DJI Phantom 4
Keterjangkauan Fasilitas Publik di Kawasan Pulau-Pulau Kecil : Studi Kasus Kabupaten Administrasi Kepulauan Seribu
Authors: Wibisono Hafidz , Musthofa Azis , Haryanto Indrawan 
Published: August 2019

Ukuran daratan yang kecil, populasi yang sedikit, sumber daya terbatas, dan isolasi geografis merupakan karakteristik khusus yang menjadikan kawasan pulau-pulau kecil objek yang menarik untuk diteliti. Dalam konteks penyediaan fasilitas publik, bukan hanya ketersediaan fasilitas yang menjadi fokus perhatian, namun keterjangkauan fasilitas dari kawasan permukiman yang tersebar di berbagai pulau menjadi hal yang penting untuk dipertimbangkan. Terbatasnya jaringan transportasi, serta moda transportasi publik merupakan beberapa keterbatasan yang harus diatasi dalam menyediakan pelayanan publik di kawasan pulau-pulau kecil. Dengan menggunakan studi kasus di Kabupaten Administrasi Kepulauan Seribu, penelitian ini memberikan gambaran secara empiris terkait dengan isu ketersediaan dan keterjangkauan fasilitas publik di kawasan pulau-pulau kecil. Adapun penelitian ini menemukan bahwa masyarakat di beberapa pulau berpenghuni masih membutuhkan waktu tempuh yang cukup lama untuk mengakses layanan beberapa fasilitas public.Kata kunci: pulau kecil, keterjangkauan, ketersediaan, fasilitasLimited land size and resources, small population, and geographically isolated are particular characteristics that make small islands an interesting research object. In the context of facilities provision, the accessibility of the facilities from residential areas which spread across several island is as important as the facilities availability. Lack of network between islands, limited publik transportation are some of constraints that have to overcome in providing equitable facilities. By using a case study in Administration Regency of Kepulauan Seribu, this research provides an empirical description related to the availability and accessibility of public facilities in small islands. Furthermore, this research found that several public facilities are still difficult to be accessed by communities in certain islands.Key words: small islands, accessibility, availability, facilities
Analisis Ketelitian Titik Kontrol Dalam Rangka Pemetaan Topografi Skala Besar di Lahan Field Research Center (FRC) Sekolah Vokasi Universitas Gadjah Mada
Authors: Prasidya Anindya Sricandra , Rahardjo Untung 
Published: August 2019

Peta topografi diperlukan dalam membantu perencanaan detail suatu area. Field Research Center (FRC) adalah lokasi kampus baru dari Sekolah Vokasi, UGM (FRC SV-UGM) di Wates, Kulon Progo yang belum memiliki peta topografi skala besar. Dalam rangka untuk menyediakannya, titik kontrol dan kerangka dasar harus disediakan dahulu. Penelitian ini bertujuan menganalisis ketelitian titik kontrol yang akan dipakai untuk menghasilkan peta topografi skala besar dari FRC SV-UGM. Pelaksanaannya terdiri atas beberapa tahapan, dimulai dari pemasangan, pengukuran, pengolahan, dan menganalisis titik kontrol, penyediaan titik kerangka dasar dalam bentuk poligon tertutup, pengukuran dan pengolahan datanya, pengukuran detil situasi (X, Y, Z), menyajikannya dalam bentuk peta dan menguji akurasinya, dan mengevaluasi hasil. Hasil yang diperoleh adalah koordinat geodetik dari tiga titik kontrol (BM1, BM2, FRC4) hasil dari pengukuran GNSS moda jaringan. Ketelitian horizontalnya kurang dari 9,1 mm dan ketelitian vertikalnya kurang dari 20,4 mm. Mengacu pada Standar Nasional Indonesia Jaring Kontrol Horizontal (SNI JKH), hasil ini telah memenuhi standar ketelitian orde-3. Selain itu, 8 titik kerangka dasar poligon tertutup telah memenuhi standar, kesalahan penutup sudutnya adalah 28,25, rasio ketelitian linier poligon adalah 1:13.601, dan kesalahan penutup beda-tinggi adalah 7,9 mm. Hasil ini memenuhi standar ketelitian orde-4 pada SNI JKH dan kelas LC pada SNI JKV. Hasil akhir berupa peta topografi skala 1:1.000 yang berisi semua detil planimetrik dan ketinggiannya. Pengujian akurasi peta ini didasarkan pada Peraturan Kepala Badan Informasi Geospasial (Perka BIG) No 15/2014. Komponen horizontal peta ini memenuhi standar ketelitian kelas 3 peta topografi skala 1:1.000 dengan CE90 < 0,5, sedangkan komponen vertikalnya memenuhi standar kelas 1 dengan LE90 < 0,2. Sehingga, dapat disimpulkan bahwa titik kontrol hasil pengukuran dengan pengamatan GNSS yang memenuhi orde-3 SNI JKH seperti pada penelitian ini dapat menghasilkan ketelitian komponen horizontal kelas 3 dan vertikal kelas 1 dari peta topografi skala 1:1.000.