bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' psychological well‐being when a child has cancer: Contribution of individual and family factors
Authors: Salvador Ágata , Crespo Carla , Barros Luísa 
Published: March 2019

AbstractObjectiveThe aim of this study was to examine the contribution of individual (positive reappraisal) and family factors (parenting satisfaction, couple relationship quality, and family life difficulty) to the psychological well‐being (PWB) of parents of children/adolescents diagnosed with cancer.MethodsThis cross‐sectional study was conducted at two pediatric oncology wards in Portugal. Two‐hundred and five parents of pediatric patients with cancer completed self‐report questionnaires assessing the use of positive reappraisal as a coping strategy, parenting satisfaction, relationship quality, family life difficulty, and PWB. Sociodemographic and clinical data were also assessed.ResultsStandard multiple regression analysis showed a significant contribution of both individual‐ and family‐level factors to parents' PWB. Specifically, the use of positive reappraisal as a coping strategy, parenting satisfaction, and relationship quality were associated with higher PWB; conversely, family life difficulty was linked to lower PWB. Sociodemographic (child's age and family's socioeconomic status) and clinical variables (time since diagnosis and treatment status) were not associated with PWB.ConclusionsThe present study identified potential resources for parents' adaptation to this stressful situation, contributing with insightful conclusions for both research and clinical practice. Screening and addressing both individual‐ and family‐level aspects may be crucial to foster parents' well‐being when a child is diagnosed with cancer.
High continuous positive airway pressure in neonates: A physiological study
Authors: Mukerji Amit , Wahab Muzafar Gani Abdul , Mitra Souvik , Mondal Tapas , Paterson Debie , Beck Jennifer , Fusch Christoph 
Published: March 2019

AbstractObjectiveWe sought to evaluate physiological cardiorespiratory implications of high pressures (>8 cmH2O) on continuous positive airway pressure (CPAP) in preterm neonates.MethodsFifteen preterm neonates at postmenstrual age ≥32 weeks on CPAP 5 cmH2O were enrolled. Pressures were increased by 2 cmH
2O increments until 13 cmH
2O. At each increment, cardiac output, electrical diaphragmatic (Edi) activity, and clinical cardiorespiratory parameters were measured. Predefined cut‐off values for changes in cardiorespiratory parameters were used as termination criteria. Data, presented as mean (SD), were compared using repeated measures analysis of variance.ResultsThe mean GA, age at study, and weight of subjects were 27.4 (2.6) weeks, 58.5 (35.5) days, and 2.3 (0.6) kg, respectively. The median (IQR) time at each CPAP increment was 10 (5, 20) min. Cardiac output (mL/kg/min) at 5, 7, 9, 11, and 13 cmH
2O were not different at 295 (75), 290 (66), 281 (69), 286 (73), and 292 (58), respectively (P = 0.99). Edi values demonstrated a trend towards decline at 9 cmH
2O before rising again. No other cardiorespiratory parameter was different across CPAP levels; no subject met termination criteria.ConclusionHigh CPAP levels were well tolerated for short durations. Further physiological and clinical research is required on safety/efficacy in neonates with more severe lung disease, as well as its impact over longer durations.
Lipid composition and macromolecular crowding effects on CYP2J2‐mediated drug metabolism in nanodiscs
Authors: Huff Hannah C. , Maroutsos Demetri , Das Aditi 
Published: March 2019

AbstractLipid composition and macromolecular crowding are key external effectors of protein activity and stability whose role varies between different proteins. Therefore, it is imperative to study their effects on individual protein function. CYP2J2 is a membrane‐bound cytochrome P450 in the heart involved in the metabolism of fatty acids and xenobiotics. In order to facilitate this metabolism, cytochrome P450 reductase (CPR), transfers electrons to CYP2J2 from NADPH. Herein, we use nanodiscs to show that lipid composition of the membrane bilayer affects substrate metabolism of the CYP2J2‐CPR nanodisc (ND) system. Differential effects on both NADPH oxidation and substrate metabolism by CYP2J2‐CPR are dependent on the lipid composition. For instance, sphingomyelin containing nanodiscs produced more secondary substrate metabolites than discs of other lipid compositions, implying a possible conformational change leading to processive metabolism. Furthermore, we demonstrate that macromolecular crowding plays a role in the lipid‐solubilized CYP2J2‐CPR system by increasing the Km and decreasing the Vmax, and effect that is size‐dependent. Crowding also affects the CYP2J2‐CPR‐ND system by decreasing both the Km and Vmax for Dextran‐based macromolecular crowding agents, implying an increase in substrate affinity but a lack of metabolism. Finally, protein denaturation studies show that crowding agents destabilize CYP2J2, while the multidomain protein CPR is stabilized. Overall, these studies are the first report on the role of the surrounding lipid environment and macromolecular crowding in modulating enzymatic function of CYP2J2‐CPR membrane protein system.
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease
Authors: Pagan Fernando L. , Hebron Michaeline L. , Wilmarth Barbara , Torres‐Yaghi Yasar , Lawler Abigail , Mundel Elizabeth E. , Yusuf Nadia , Starr Nathan J. , Arellano Joy , Howard Helen H. , Peyton Margo , Matar Sara , Liu Xiaoguang , Fowler Alan J. , Schwartz Sorell L. , Ahn Jaeil , Moussa Charbel 
Published: March 2019

AbstractNilotinib is a broad‐based tyrosine kinase inhibitor with the highest affinity to inhibit Abelson (c‐Abl) and discoidin domain receptors (DDR1/2). Preclinical evidence indicates that Nilotinib reduces the level of brain alpha‐synuclein and attenuates inflammation in models of Parkinson's disease (PD). We previously showed that Nilotinib penetrates the blood‐brain barrier (BBB) and potentially improves clinical outcomes in individuals with PD and dementia with Lewy bodies (DLB). We performed a physiologically based population pharmacokinetic/pharmacodynamic (popPK/PD) study to determine the effects of Nilotinib in a cohort of 75 PD participants. Participants were randomized (1:1:1:1:1) into five groups (n = 15) and received open‐label random single dose (RSD) 150:200:300:400 mg Nilotinib vs placebo. Plasma and cerebrospinal fluid (CSF) were collected at 1, 2, 3, and 4 hours after Nilotinib administration. The results show that Nilotinib enters the brain in a dose‐independent manner and 200 mg Nilotinib increases the level of 3,4‐Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), suggesting alteration to dopamine metabolism. Nilotinib significantly reduces plasma total alpha‐synuclein and appears to reduce CSF oligomeric: total alpha‐synuclein ratio. Furthermore, Nilotinib significantly increases the CSF level of triggering receptors on myeloid cells (TREM)‐2, suggesting an anti‐inflammatory effect. Taken together, 200 mg Nilotinib appears to be an optimal single dose that concurrently reduces inflammation and engages surrogate disease biomarkers, including dopamine metabolism and alpha‐synuclein.
New absolute stability results for Lurie systems with interval time‐varying delay based on improved Wirtinger‐type integral inequality
Authors: Zhang Liansheng , Wang Shuxia , Yu Wei , Song Yongduan 
Published: March 2019

SummaryThis work focuses on the absolute stability problem of Lurie control system with interval time‐varying delay and sector‐bounded nonlinearity. Firstly, we present a refined Wirtinger's integral inequality and establish an improved Wirtinger‐type double integral inequality. Secondly, a modified augmented Lyapunov‐Krasovskii functional (LKF) is constructed to analyze the stability of Lurie system, where the information on the lower and upper bounds of the delay and the delay itself are fully exploited. Based on the proposed integral inequalities and some bounding techniques, the upper bound of the derivative of the LKF can be estimated more tightly. Accordingly, the proposed absolute stability criteria, formulated in terms of linear matrix inequalities, are less conservative than those in previous literature. Finally, numerical examples demonstrate the effectiveness and advantage of the proposed method.
What do core practices offer in preparing novice science teachers for equitable instruction?
Authors: Kang Hosun , Zinger Doron 
Published: March 2019

AbstractThis study explores the affordances and constraints of using the four core practices of ambitious science teaching (AST) as the main curriculum of science methods courses in preparing novice teachers for equitable instruction. Employing a longitudinal qualitative case study approach, this study follows three novice secondary science teachers' trajectories over 3 years, from their preparation to their second year of teaching. Participants were three White women who taught primarily Latinx, English learners, exceptional learners, and/or those who live in poverty. The contemporary vision of science learning promoted by the Next Generation Science Standards and critical race theory guide our analysis of novice teachers' instruction. Findings suggest that using AST practices as the main curriculum of science methods courses can help prepare novice teachers for equityifthe approximation of these practices facilitates novices in problematizing their normalized views, expectations, and practices of disciplinary teaching and learning. The core practices are limited, however, in their ability to develop novice teachers' critical consciousness about racism and systemic inequity, which profoundly affects interactions with marginalized youth in classrooms.
A Novel Surface‐Tethered Double‐Signal Electrochemiluminescence Sensor Based on Luminol@Au and CdS Quantum Dots for Mercury Ion Detection
Authors: Hu Yunxia , Liu Yuan , Wang Sui , Guo Zhiyong , Hu Yufang , Xie Hongzhen 
Published: March 2019

AbstractA novel surface‐tethered double‐signals electrochemiluminescence (ECL) sensor has been developed for the detection of mercury (II) ions (Hg2+). Firstly, cysteamine functionalized CdS quantum dots (CdS QDs‐Cys) as one of ECL nanoprobes were deposited onto the glass carbon electrode. Then electrode was modified with carboxylated thymine via the carboxyl groups of thymine and amino groups of CdS QDs‐Cys. Due to the specific recognition between thymine and Hg2+, the above electrode acted as the substrate to capturing target Hg2+, which could further bind luminol@Au‐Cys‐T multifunctional nanoarchitecture. It was found that the ECL intensity of luminol and CdS QDs both increased with the increasing of mercury ion concentration. Under the optimum condition, the logarithm of the ratio of two signals was linearly proportionally to the logarithmic concentrations of Hg2+ in the range 0.005 ∼ 2.5 nM with a limit of detection of 0.002 nM (S/N=3). The novel sensor displayed good reproducibility and sensitivity and provided an alternative analytical approach for the following research.
Phenazine‐Based Fluorescence “Turn‐Off” Sensor for Fluoride: Application on Real Samples and to Cell and Zebrafish Imaging
Authors: Naha Sanay , Velmathi Sivan 
Published: March 2019

AbstractIn the present work, we report the design of a novel chemosensor 2‐(1H‐indole‐3‐yl)‐1H‐imidazo[4,5‐b]phenazine, (R) for fluoride ion detection via a naked eye observable colour change from light yellow to brown along with 10 fold ratiometric fluorescence quenching from green to no fluorescence in a matrix containing a large number of similar toxic anions in aqueous dimethylsulfoxide (30% H2O + DMSO) solution. The sensing mechanism was ascertained to be the fluoride triggered deprotonation of imidazole as well as indole moiety of R which is supported by 1:2 saturation level equivalence of R‐F‐. R was fully characterized through FT‐IR, 1H, 13C NMR and HRMS. R is an effective receptor for F‐ within a wide range of pH that indicates its bio‐compatibility. LoD and Ka for F‐ were found to be 1.8×10‐6 M (below 0.34 mg/Liter) and 2.7 × 104 M‐1 respectively. The experimental observations were supported by the theoretical calculations using density functional theory. R also showed its potential practical applicability for fluoride detection in toothpaste solution. Furthermore, to prove its nontoxicity, probe R also applied to a cytotoxicity assay of HeLa cells followed by confocal fluorescence cells imaging and Zebrafish imaging experiments.
Photoresponsive Self‐Assembled DNA Nanomaterials: Design, Working Principles, and Applications
Authors: Tam Dick Yan , Zhuang Xinyu , Wong Sze Wing , Lo Pik Kwan 
Published: March 2019

AbstractPhotoresponsive DNA nanomaterials represent a new class of remarkable functional materials. By adjusting the irradiation wavelength, light intensity, and exposure time, various photocontrolled DNA‐based systems can be reversibly or irreversibly regulated in respect of their size, shape, conformation, movement, and dissociation/association. This Review introduces the most updated progress in the development of photoresponsive DNA‐based system and emphasizes their advantages over other stimuli‐responsive systems. Their design and mechanisms to trigger the photoresponses are shown and discussed. The potential application of these photon‐responsive DNA nanomaterials in biology, biomedicine, materials science, nanophotonic and nanoelectronic are also covered and described. The challenges faced and further directions of the development of photocontrolled DNA‐based systems are also highlighted.
Dynamically Programmed Switchable DNA Hydrogels Based on a DNA Circuit Mechanism
Authors: Oishi Motoi , Nakatani Kazuki 
Published: March 2019

AbstractBiological stimuli‐responsive DNA hydrogels have attracted much attention in the field of medical engineering owing to their unique phase transitions from gel to sol through cleavage of DNA cross‐linking points in response to specific biomolecular inputs. In this paper, a new class of biological stimuli‐responsive DNA hydrogels with a dynamically programmed DNA system that relies on a DNA circuit system through cascading toehold‐mediated DNA displacement reactions is constructed, allowing the catalytic cleavage of cross‐linking points and main chains in response to an appropriate DNA input. The dynamically programmed DNA hydrogels exhibit a significant sharp phase transition from gel to sol in comparison to another DNA hydrogel showing noncatalytic cleavage of cross‐linking points due to synchronization of the catalytic cleavage of cross‐linking points and the main chains. Further, the sol–gel phase transitions of the DNA hydrogels in response to the DNA input are easily tunable by changing the cross‐linking density. Additionally, with a structure‐switching aptamer, DNA hydrogels encapsulating PEGylated gold nanoparticles can be used as enzyme‐free signal amplifiers for the colorimetric detection of adenosine 5′‐triphosphate (ATP); this detection system provides simplicity and higher sensitivity (limit of detection: 5.6 × 10−6 m at 30 min) compared to other DNA hydrogel‐based ATP detection systems.
Evaluation of the histopathological extent of neoplastic infiltration in intestinal tumours in cats
Authors: Morrice Michael , Polton Gerry , Beck Sam 
Published: March 2019

AbstractWith the exception of intestinal lymphoma, surgery is the most commonly recommended treatment for solitary feline intestinal tumours. However, there is a lack of evidence to substantiate resection margin recommendations for these tumours. The aim of this study was to add knowledge concerning resection margins for discrete intestinal masses in cats. Thirty confirmed feline intestinal tumours removed at veterinary centres across theUKfrom March 2017 to March 2018 underwent histological assessment at the palpable edge of the intestinal tumour and then at every 1 cm increment to the surgeon‐cut tissue border in oral, aboral and mesenteric directions. Histological margin recommendations were developed for carcinoma and lymphoma tumour types and non‐lymphoma intestinal tumours collectively. Seventeen intestinal lymphomas, nine carcinomas, two sarcomas and two mast cell tumours were evaluated in this study. Seven of the nine intestinal carcinomas would have been completely removed with histological margins of 4 cm in oral and aboral directions. Both sarcomas and one mast cell tumour would have been removed in their entirety with 4 cm histological margins in oral and aboral directions. There was extensive and varied microscopic invasion of intestinal tissue away from discrete intestinal lymphomas in the majority of the cases in this study. There is increasing evidence in veterinary as well as human literature supporting the role of surgical resection in the treatment of discrete intestinal lymphoma. If surgery is to be considered this study supports the removal of the gross tumour only. A histological margin of 4 cm should be considered, where possible, for intestinal masses other than lymphomas.
A reduction in triclosan and triclocarban in water resource recovery facilities’ influent, effluent, and biosolids following the U.S. Food and Drug Administration's 2013 proposed rulemaking on antibacterial products
Authors: Brose Dominic A. , Kumar Kuldip , Liao Anna , Hundal Lakhwinder S. , Tian Guanglong , Cox Albert , Zhang Heng , Podczerwinski Edward W. 
Published: March 2019

AbstractPharmaceutical and personal care product compounds (PPCPs) comprise a large and diverse group of chemical compounds, including prescription and over‐the‐counter drugs and cleaning agents. Although PPCPs in the effluent and biosolids of water resource recovery facilities (WRRFs) are currently not regulated, public interest has led the Metropolitan Water Reclamation District of Greater Chicago to monitor for 11 PPCPs in the influent, effluent, and biosolids at its seven WRRFs. In 2016, the U.S. Food and Drug Administration (FDA) issued a final rule establishing that 19 specific ingredients, including triclosan and triclocarban, were no longer generally recognized as safe and effective, which prohibits companies from marketing soaps as antibacterial if they contain one or more of these ingredients. It was presumed that since the proposed rulemaking in 2013, manufacturers began to remove these active ingredients from their products. Annual monitoring of 11 PPCPs from 2012 to 2017 demonstrated a 71% decrease in triclosan and 72% decrease in triclocarban in per capita influent loading into seven WRRFs. There was a 70% decrease in triclosan and 80% decrease in triclocarban concentrations in biosolids. These declines suggest the FDA rule for the reduction in use of these compounds was effective and resulted in manufacturers removing these ingredients from their products.Practitioner points

Reduction in triclosan and triclocarban per capita influent loading observed from 2012 to 2017.

Reduction in triclosan and triclocarban biosolids loading observed from 2012 to 2017.

2016 FDA rulemaking on antimicrobial soaps was effective in removing triclosan and triclocarban from these products.

Positive impact on quality of biosolids land applied to farmland.
Integration of catalytic ozonation and adsorption processes for increased efficiency of textile wastewater treatment
Authors: Xu Shengkai , Bi Huaqi , Liu Guangqing , Su Bensheng 
Published: March 2019

AbstractAdvanced and optimized textile wastewater treatment by catalytic ozonation and activated carbon (AC) adsorption was investigated. Scanning electron microscopy, X‐ray diffraction, and X‐ray photoelectron spectroscopy indicated that Mn and Ce oxides were successfully loaded on the γ‐Al2O3 support, and MnO2, Mn2O3, CeO2, and Ce2O3 were the main components of the catalyst. Actual textile wastewater from biochemical effluent was used as experiment wastewater. The removal efficiencies of chemical oxygen demand (COD) and chromaticity were approximately 30.6% (414–287 mg/L on average) and 99.3% (4,033 times to 27 times on average), respectively during the 30‐day on‐site continuous‐flow test with an ozone dosage, contact time, and gas–liquid ratio of 100 mg/L, 15.7 min, and 2.9, respectively. Following 1 g/L AC adsorption, the effluent COD concentration was reduced to 40 mg/L. By contrast, AC adsorption without catalytic ozonation as pretreatment required 10 g/L AC dosage to achieve similar treatment results. Gas chromatography–mass spectrometry analyses indicated that volatile phenols, sulfides, and aniline in wastewater were completely removed after treatment. Inductively coupled plasma results further showed that the active components of MnOx–CeOx in the catalyst were stable after continuous use for 60 days.Practitioner points

Mesoporous catalyst synthesized by impregnating MnOx–CeOx on γ‐Al2O3 support.

Catalytic ozonation and AC adsorption were combined to degrade organics.

Maximum degradation of COD and chromaticity by optimizing process variables.

The efficiency of the method was compared to that of single AC adsorption.
Vitis species, vintage, and alcoholic fermentation do not drive population structure in Starmerella bacillaris (synonym Candida zemplinina) species
Authors: Raymond Eder María Laura , Conti Francisco , Bely Marina , Masneuf‐Pomarède Isabelle , Albertin Warren , Rosa Alberto Luis 
Published: March 2019

AbstractThe yeast species Starmerella bacillaris (synonym Candida zemplinina) is widely associated with oenological ecosystems and is frequently isolated from grape and grape must. Previous work showed that the genetic diversity of this species is high in wine environments and it is shaped by geographic location. Most analysed C. zemplinina strains, however, have been isolated from Vitis vinifera, disregarding the existence of other worldwide‐distributed Vitis species used in winemaking. In this work, we address the impact of the Vitis species and geographic location on the genetic diversity of C. zemplinina. Microsatellite genotyping analysis was applied to two remarkable populations of C. zemplinina from Argentina and Portugal (Azores Archipelago), isolated from neighbouring V. vinifera and Vitis labrusca vineyards. The study also included a large population of previously characterized worldwide‐isolated C. zemplinina strains. Genetic analyses confirmed that geographic localization significantly shaped the genetic diversity of C. zemplinina. No genetic differentiation on the basis of the Vitis species was recorded, indicating that C. zemplinina populations from neighbouring V. vinifera and V. labrusca vineyards are genetically homogeneous. In addition, no impact of the vintage was found on the C. zemplinina populations being both highly diversified and homogeneous during initial stages of alcoholic fermentation. Altogether, these results confirmed that winemaking‐related factors (i.e., vintage, Vitis species, and alcoholic fermentation) do not impact the genetic diversity of C. zemplinina and that only geographic localization significantly shapes this yeast species.