bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transhepatic forceps biopsy after PTCD for histological assessment of bile duct stenoses or occlusions
Authors: Warnken Eva-Marie , Uder Michael , Stein Hubert , Wucherer Michael , Lell Michael , Muschweck Herbert , Adamus Ralf 
Published: February 2019

Abstract
Purpose The goal of this study was to evaluate the experience of 11 years of wire-guided forceps biopsy via PTCD in patients with obstructive jaundice.
Materials and methods In a retrospective approach, 56 biopsies in 51 patients were analyzed (22 female, 29 male). Data was collected from 2006 to 2016. Mean age was 71 years (range: 34 – 86 years). Data was extracted from dig. Patients’ records (KIS, PACS, RIS) to be analyzed in Microsoft Excel.
Results All 56 procedures were technically successful. Stenosis in anastomoses were benign due to scarring in 7 patients and in 9 due to papillitis or others. In 4 patients, results in anastomosis were malignant. In 19 patients without anastomosis, CCC was the diagnosis, thereof 10 klatskin, 9 stenosis in other locations, followed by gastric, pancreatic, and colon carcinoma in 5, 3, and 2 patients. Three patients had a CUP (multimetering in case of more than 1 related category). Overall results were 35 mal. and 16 benign, 76.8 % of all proc. had a correct histopathologic result, and 23.2 % were false negative. Sensitivity was 65.8 %, which results in negative predictive value of 58.1 %. There was no false positive and so specificity was 100 %, as was the positive predictive value. False negative results (no malignancy but clinically and imaging suspect) were corrected by rerunning the procedure, by CT-guided biopsy or by 1 PET-CT. In 1 case the surg. sample brought the result. Minor complications occurred in 8 patients: shivering in 1 case, distinct but hemodynamically not relevant hemobilia in 5 cases, 2 portovenal bleedings. All bleedings were short-term and self-limiting.
Conclusion Despite good feasibility, low peri- and post-interv. risk and high validity the forceps biopsy via PTCD is not widely used. For experienced interventionalists, it is an effective method for obtaining histology.
Higher Axial Tibiofemoral Rotation and Functional Outcomes with Mobile-Bearing Compared with Fixed-Bearing Total Knee Arthroplasty at 1- but Not at 2-Year Follow-Up—A Randomized Clinical Trial
Authors: Amaro Joicemar Tarouco , Novaretti João Victor , Astur Diego Costa , Cavalcante Elton Luiz Batista , Rodrigues Junior Adilson Góes , Debieux Pedro , Kaleka Camila Cohen , Cohen Moisés 
Published: February 2019

AbstractThe objective of this study was to determine in vivo knee kinematics and clinical outcomes of patients who underwent fixed- and mobile-bearing total knee arthroplasty (TKA) at 1- and 2-year follow-up. This prospective double-blinded randomized controlled trial was performed from November 2011 to December 2012. A total of 64 patients were randomized to fixed- and mobile-bearing TKA groups (32 patients in each group). All patients were evaluated with the following: three-dimensional in vivo knee kinematics analysis during gait, stepping up and stepping down stair steps, and getting up from and sitting on a chair; and knee range of motion and patient-reported outcome measures (Knee Outcome Survey Activities of Daily Living Scale [KOS-ADLS] and pain visual analog scale [VAS]) at 1- and 2-year follow-up. Descriptive statistics (means, standard deviations, and percentages) were calculated for all variables. The Kolmogorov–Smirnov test was used to test if variables were normally distributed. A Student's t-test was used to compare continuous variables between patients in the two groups. The chi-square test was used to compare the groups with respect to categorical variables. The α level for statistical significance was set at p < 0.05. The mean axial tibiofemoral rotation in patients who underwent mobile-bearing TKA was significantly higher during gait (13.3 vs. 10.7), stepping up (12.8 vs. 10) stair steps, and getting up (16.1 vs. 12.1) from a chair compared with fixed-bearing TKA patients at 1-year follow-up (p < 0.05). KOS-ADLS function score was significantly higher in the mobile-bearing compared with the fixed-bearing TKA group (32 vs. 27.7) at 1-year follow-up (p < 0.05). No significant difference in kinematics and clinical outcomes between fixed- and mobile-bearing TKA groups was observed at 2-year follow-up (p > 0.05). Based on the results of this study, mobile-bearing TKA allowed a higher degree of rotation when walking, stepping up stair steps, and standing up from a chair, and had higher functional outcomes compared with fixed-bearing TKA at 1-year follow-up. However, no difference in in vivo kinematics or in clinical outcomes was observed between fixed- and mobile-bearing prostheses at 2-year follow-up.
Nonlinear dynamics underlying sensory processing dysfunction in schizophrenia
Authors: Lainscsek Claudia , Sampson Aaron L. , Kim Robert , Thomas Michael L. , Man Karen , Lainscsek Xenia ,   The COGS Investigators, Swerdlow Neal R. , Braff David L. , Sejnowski Terrence J. , Light Gregory A. , Light Gregory A. , Swerdlow Neal R. , Thomas Michael L. , Green Michael F. , Greenwood Tiffany A. , Gur Raquel E. , Gur Ruben C. , Lazzeroni Laura C. , Nuechterlein Keith H. , Radant Allen D. , Seidman Larry J. , Sharp Richard F. , Siever Larry J. , Silverman Jeremy M. , Sprock Joyce , Stone William S. , Sugar Catherine A. , Tsuang Debby W. , Tsuang Ming T. , Turetsky Bruce I. , Braff David L. 
Published: February 2019

Significance
One of the fundamental challenges of neuroscience is to understand the seamless orchestration of many interconnected brain regions, which is needed to produce the integrated experience of cognition. This paper describes a method based on dynamical systems theory to identify important nonlinear features underlying brain signals. We show that this method can indeed detect unique dynamical states underlying normal and altered auditory information processing in large cohorts of healthy subjects and schizophrenia patients. These dynamical states correspond to network changes preceding well-known auditory–neurophysiological responses. Results indicate that brain signals can be analyzed using a rather unconventional method to extract important large-scale dynamical information that is not apparent from conventional methods commonly used in the study of neuropsychiatric disorders.
Quantitative zeptomolar imaging of miRNA cancer markers with nanoparticle assemblies
Authors: Qu Aihua , Sun Maozhong , Xu Liguang , Hao Changlong , Wu Xiaoling , Xu Chuanlai , Kotov Nicholas A. , Kuang Hua 
Published: February 2019

Significance
Engineering of reconfigurable nanoparticle assemblies enabled the practical realization of multiplexed detection, monitoring, and in vivo imaging of miRNA in live cells and animals, which was previously impeded by the fast degradation of these essential epigenetic markers. Nanoparticle superstructures afford rapid quantitative assessment of the imaging results, facilitating proliferation of digital personalized medicine.
Cortical route for facelike pattern processing in human newborns
Authors: Buiatti Marco , Di Giorgio Elisa , Piazza Manuela , Polloni Carlo , Menna Giuseppe , Taddei Fabrizio , Baldo Ermanno , Vallortigara Giorgio 
Published: February 2019

Significance
Newborns show a remarkable ability to detect faces even minutes after birth, an ecologically fundamental skill that is instrumental for interacting with their conspecifics. What are the neural bases of this expertise? Using EEG and a slow oscillatory visual stimulation, we identified a reliable response specific to facelike patterns in newborns, for which underlying cortical sources overlap with the adult face-specific cortical circuit. This suggests that the development of face perception in infants might rely on an early cortical route specialized in face processing already shortly after birth.
Loss of MPC1 reprograms retinal metabolism to impair visual function
Authors: Grenell Allison , Wang Yekai , Yam Michelle , Swarup Aditi , Dilan Tanya L. , Hauer Allison , Linton Jonathan D. , Philp Nancy J. , Gregor Elizabeth , Zhu Siyan , Shi Quan , Murphy Joseph , Guan Tongju , Lohner Daniel , Kolandaivelu Saravanan , Ramamurthy Visvanathan , Goldberg Andrew F. X. , Hurley James B. , Du Jianhai 
Published: February 2019

Significance
Mitochondrial pyruvate carrier (MPC) is responsible for transporting pyruvate from glycolysis into mitochondria for oxidative phosphorylation. In the vertebrate retinas, the majority of glucose is metabolized into lactate by glycolysis rather than being oxidized in the mitochondria. Here, we show that although a small percentage of glucose is transported through MPC, deletion of MPC impairs visual function, decreases the viability of photoreceptors, disrupts photoreceptor ultrastructure, and causes glial activation. We find that MPC is required for maintaining the retinal metabolism in amino acids, neurotransmitters, and ketone bodies.
Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice
Authors: Landowski Michael , Kelly Una , Klingeborn Mikael , Groelle Marybeth , Ding Jin-Dong , Grigsby Daniel , Bowes Rickman Catherine 
Published: February 2019

SignificanceThe complement factor H (CFH) Y402H polymorphism (rs1061170) imparts the strongest risk for age-related macular degeneration (AMD), the leading cause of blindness in the elderly. Popular thinking holds that the CFH H402 variant increases complement activation in the eye, predisposing susceptibility to disease. However, clinical trials of complement inhibitors in AMD patients have failed. Here we provide an explanation, showing CFH variant-specific differences in the presentation of AMD-like pathologies. We show that aged mice expressing the human H402, but not Y402 variant, (i) develop AMD-like symptoms and (ii) display differences in their systemic and ocular lipoprotein levels, but not in their complement activation, after diet. These findings support targeting lipoproteins for the treatment of AMD.
PILS6 is a temperature-sensitive regulator of nuclear auxin input and organ growth in
Arabidopsis thaliana
Authors: Feraru Elena , Feraru Mugurel I. , Barbez Elke , Waidmann Sascha , Sun Lin , Gaidora Angelika , Kleine-Vehn Jürgen 
Published: February 2019

Significance
High temperature (HT) strongly modulates plant growth and eventually threatens yield stability. HT induces biosynthesis of the phytohormone auxin, which in turn increases cellular auxin levels and growth rates in shoots. This mechanism does not control HT-induced root growth and, hence, the role of auxin in this process is currently controversial. Here we show that the putative auxin carrier PIN-LIKES 6 (PILS6) localizes to the endoplasmic reticulum, where it gates nuclear auxin accumulation and perception. HT decreases the abundance of PILS6 proteins, consequently increasing nuclear auxin signaling and root growth. Our data dismantle current controversy, revealing an alternative subcellular mechanism in roots, which links PILS6-dependent control of cellular auxin sensitivity with HT-induced organ growth.
Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling
Authors: Ondeck Matthew G. , Kumar Aditya , Placone Jesse K. , Plunkett Christopher M. , Matte Bibiana F. , Wong Kirsten C. , Fattet Laurent , Yang Jing , Engler Adam J. 
Published: February 2019

Significance
Gradual stiffening of the native extracellular matrix has been implicated in promoting breast cancer progression through stiffness-mediated signaling. Herein, we probe mammary epithelial cell responses to substrate stiffness with a dynamically stiffened hydrogel, enabling investigation of how the change in substrate stiffness impacts collective cell behaviors. We demonstrate that signaling pathways, both paracrine and mechanosensing, impact mammary epithelial cell response to stiffening and act in concert to drive epithelial-mesenchymal plasticity. Interestingly, previous static stiffness hydrogel studies did not observe this interplay of signaling, highlighting the need for dynamic materials to recapitulate disease development. These responses can also be inhibited, individually and together, demonstrating how dynamic stiffening drives cancer progression.
Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior
Authors: Sun Tingting , Song Zihua , Tian Yanghua , Tian Wenbo , Zhu Chunyan , Ji Gongjun , Luo Yudan , Chen Shi , Wang Likui , Mao Yu , Xie Wen , Zhong Hui , Zhao Fei , Luo Min-Hua , Tao Wenjuan , Wang Haitao , Li Jie , Li Juan , Zhou Jiangning , Wang Kai , Zhang Zhi 
Published: February 2019

Significance
The pathophysiology underlying obsessive-compulsive disorder (OCD) remains unclear, leading to major challenges in the treatment of OCD patients. Here, we defined a projection from the basolateral amygdala glutamate neurons to the medial prefrontal cortex glutamate and GABA neurons and described the putative importance of this circuit in manifesting the checking symptoms of OCD in mice. In addition, the above major findings were further verified in an fMRI mouse study. These findings raise the possibility of developing optimal treatments for OCD that involve the use of nondrug approaches, such as transcranial magnetic stimulation, that target the converging pathways.
Redox traits characterize the organization of global microbial communities
Authors: Ramírez-Flandes Salvador , González Bernardo , Ulloa Osvaldo 
Published: February 2019

Significance
Biological communities are conventionally described as assemblages of species, whose ecological roles are known or predictable from their observable morphology. In microbial ecology, such a taxonomic approach is hindered by limited capacity to discriminate among different microbes, which bear highly dynamic genomes and establish complex associations. Approaches based on culture-independent functional genes profiling might overcome these problems, but a set of usable established genes in a general situation is still lacking. We show that genes related to reduction-oxidation (redox) processes separate microbial communities into their corresponding biomes. This redox-based characterization is linked to the microbial energetics of ecosystems and to most biogeochemical cycles and might be useful for assessing the impact of environmental degradation on the ecosystem services, underpinned by microorganisms.
Human Cooperation When Acting Through Autonomous Machines
Authors: de Melo Celso M. , Marsella Stacy , Gratch Jonathan 
Published: February 2019

SignificanceAutonomous machines that act on our behalf—such as robots, drones, and autonomous vehicles—are quickly becoming a reality. These machines will face situations where individual interest conflicts with collective interest, and it is critical we understand if people will cooperate when acting through them. Here we show, in the increasingly popular domain of autonomous vehicles, that people program their vehicles to be more cooperative than they would if driving themselves. This happens because programming machines causes selfish short-term rewards to become less salient, and that encourages cooperation. Our results further indicate that personal experience influences how machines are programmed. Finally, we show that this effect generalizes beyond the domain of autonomous vehicles and we discuss theoretical and practical implications.
Morphogenesis of termite mounds
Authors: Ocko Samuel A. , Heyde Alexander , Mahadevan L. 
Published: February 2019

Significance
Termite mounds are the result of the collective behavior of termites working to modify their physical environment, which in turn affects their behavior. During mound construction, environmental factors such as heat flow and gas exchange affect the building behavior of termites, and the resulting change in mound geometry in turn modifies the response of the internal mound environment to external thermal oscillations. Our study highlights the principles of self-organized animal architecture driven by the coupling of environmental physics to organismal behavior and might serve as a natural inspiration for the design of sustainable human architectures.
Mid-infrared feed-forward dual-comb spectroscopy
Authors: Chen Zaijun , Hänsch Theodor W. , Picqué Nathalie 
Published: February 2019

Significance
Each molecule leaves characteristic absorptions, which enable one to unambiguously identify and quantify it, and to understand its structure and dynamics. Such fingerprints, strong in the mid-infrared region of the electromagnetic spectrum, can be accessed by measuring the intensity of light transmitted through a medium as a function of its frequency. Here, we describe a spectrometer for mid-infrared spectroscopy based on two frequency comb generators, light sources emitting narrow evenly spaced laser lines over a broad spectral bandwidth. Our instrument without moving parts simultaneously measures broad high-resolution spectra with calibration of the frequency scale directly to an atomic clock and precise spectral line shapes. These features are obtained from the experimental data without any need for corrective processing.
Structural studies on bacterial system used in the recognition and uptake of the macromolecule alginate
Authors: Maruyama Yukie , Hashimoto Wataru , Murata Kousaku 
Published: February 2019

ABSTRACT
Alginate is an acidic heteropolysaccharide produced by brown seaweed and certain kinds of bacteria. The cells of Sphingomonas sp. strain A1, a gram-negative bacterium, have several alginate-degrading enzymes in their cytoplasm and efficiently utilize this polymer for their growth. Sphingomonas sp. strain A1 cells can directly incorporate alginate into their cytoplasm through a transport system consisting of a “pit” on their cell surface, substrate-binding proteins in their periplasm, and an ATP-binding cassette transporter in their inner membrane. This review deals with the structural and functional aspects of bacterial systems necessary for the recognition and uptake of alginate.
Arabic language in Zanzibar: past, present, and future
Authors: Gintsburg Sarali 
Published: February 2019

ABSTRACT
The debate on the status and the role of Standard/Classical Arabic versus Dialectal Arabic in the Arab World has a long history. In parallel to this, voices calling for giving Dialectal Arabic the status of the official state language and cancelling Standard Arabic altogether are becoming louder. This debate is being fuelled by the rapidly developing theory of superdiversity which claims that, due to the rapid changes that happened to the world after 1991, and increasing globalization associated with worldwide migration, easy access throughout the world to internet and social networks, video hosting services and satellite television, societies all over the world have become extremely diverse linguistically. This theory also draws on language ideologies, the concept that suggests that the traditional idea of a “language” is an ideological artefact. Is this approach valid for understanding what is happening in the Arabic language? I will attempt to answer this question by examining the status of the Arabic language on the margins of the Arab world – in Zanzibar. For centuries, the Arabic language has been one of the key languages spoken in Zanzibar, but it has now been practically replaced by Swahili.
Spectroscopy of a tetrahedral doubly magic candidate nucleus <sup>160</sup><sub>70</sub>Yb<sub>90</sub>
Authors: Saha Arunabha , Bhattacharjee T , CURIEN Dominique , Dudek Jerzy , Dedes I , Mazurek Katarzyna , Gozdz Andrzej , Tagami S , Shimizu Yoshifumi R , Banerjee Sudhee Ranjan , Rajbanshi S , Bisoi A , de Angelis Giacomo , Bhattacharya Soumik , Bhattacharyya S , Biswas S , Chakraborty A , Das Gupta S , Dey B , Goswami A , Mondal D , Pandit D , Palit Rudrajyoti , Roy T , Singh R. P. , Saha Sarkar Maitreyee , Saha Sudipta , Sethi J 
Published: February 2019

Abstract
The decay scheme of $^{160}$Yb nucleus populated in the $^{148}$Sm($^{16}$O, 4n)$^{160}$Yb reaction at 90 MeV has been studied. The gamma-coincidence data have been collected by using Indian National Gamma Array (INGA) composed of twenty Compton-suppressed Clover-Germanium detectors. Compared to the prior publications, the level scheme has been significantly modified owing to the observation of triple $\gamma$-coincidences and the measurements of $\gamma$ intensities, R$_{\theta}$ (asymmetry ratio), DCO (Directional Correlation of Oriented States) and IPDCO (Integrated Polarisation Directional Correlation of Oriented States) ratios.&#13;
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Theoretical results relevant for the exotic shape-coexistence related to the present context are presented and discussed. They illustrate the consequences of the fact that $^{160}$Yb is expected to be a doubly-magic (Z=70 and N=90) tetrahedral-symmetry nucleus as predicted by other authors. The historical criteria of identification of such a symmetry in nuclei are critically revisited in the context of the actual measurement and interpretation of its results and the precise new criteria are formulated employing recent results of the Fukuoka-Strasbourg collaboration.&#13;
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The experimental results are interpreted and discussed in detail. Limiting values of branching ratios for transitions observed by other authors but unseen in the present work are estimated. The population criteria of the $\beta$ and $\gamma$ vibration bands are revisited and discussed.&#13;
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Although no indication of the presence of the stable tetrahedral configuration has been obtained, arguments are given towards the possible presence of the $Y_{32}$ (`tetrahedral component') vibrations around the ground-state equilibrium. With the improvement of the spectroscopic information provided by the new data the way is opened for designed experiment(s) based on the unambiguous identification criteria of tetrahedral symmetry presented in this article.
Citywide Control of Aedes aegypti (Diptera: Culicidae) during the 2016 Zika Epidemic by Integrating Community Awareness, Education, Source Reduction, Larvicides, and Mass Mosquito Trapping
Authors: Barrera Roberto , Harris Angela , Hemme Ryan R , Felix Gilberto , Nazario Nicole , Muñoz-Jordan Jorge L , Rodriguez Damaris , Miranda Julieanne , Soto Eunice , Martinez Stephanie , Ryff Kyle , Perez Carmen , Acevedo Veronica , Amador Manuel , Waterman Stephen H 
Published: February 2019

Abstract
This investigation was initiated to control Aedes aegypti and Zika virus transmission in Caguas City, Puerto Rico, during the 2016 epidemic using Integrated Vector Management (IVM), which included community awareness and education, source reduction, larviciding, and mass-trapping with autocidal gravid ovitraps (AGO). The epidemic peaked in August to October 2016 and waned after April 2017. There was a preintervention period in October/November 2016 and IVM lasted until August 2017. The area under treatment (23.1 km2) had 61,511 inhabitants and 25,363 buildings. The city was divided into eight even clusters and treated following a cluster randomized stepped-wedge design. We analyzed pools of female Ae. aegypti adults for RNA detection of dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV) viruses using 360 surveillance AGO traps every week. Rainfall, temperature, and relative humidity were monitored in each cluster. Mosquito density significantly changed (generalized linear mixed model; F8, 14,588 = 296; P < 0.001) from 8.0 ± 0.1 females per trap per week before the intervention to 2.1 ± 0.04 after the percentage of buildings treated with traps was 60% and to 1.4 ± 0.04 when coverage was above 80%. Out of a total 12,081 mosquito pools, there were 1 DENV-, 7 CHIKV-, and 49 ZIKV-positive pools from October 2016 to March 2017. Afterward, we found only one positive pool of DENV in July 2017. This investigation demonstrated that it was possible to scale up effective Ae. aegypti control to a medium-size city through IVM that included mass trapping of gravid Ae. aegypti females.