bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics
Authors: Wang Xuerui , Zhang Yuting , Wang Xiaoyu , Andres‐Garcia Eduardo , Du Peng , Giordano Lorena , Wang Lin , Hong Zhou , Gu Xuehong , Murad Sohail , Kapteijn Freek 
Published: August 2019

AbstractXe is only produced by cryogenic distillation of air, and its availability is limited by the extremely low abundance. Therefore, Xe recovery after usage is the only way to guarantee sufficient supply and broad application. Herein we demonstrate DD3R zeolite as a benchmark membrane material for CO2/Xe separation. The CO2 permeance after an optimized membrane synthesis is one order magnitude higher than for conventional membranes and is less susceptible to water vapour. The overall membrane performance is dominated by diffusivity selectivity of CO2 over Xe in DD3R zeolite membranes, whereby rigidity of the zeolite structure plays a key role. For relevant anaesthetic composition (<5 % CO2) and condition (humid), CO2 permeance and CO2/Xe selectivity stabilized at 2.0×10−8 mol m−2 s−1 Pa−1 and 67, respectively, during long‐term operation (>320 h). This endows DD3R zeolite membranes great potential for on‐stream CO2 removal from the Xe‐based closed‐circuit anesthesia system. The large cost reduction of up to 4 orders of magnitude by membrane Xe‐recycling (>99+%) allows the use of the precious Xe as anaesthetics gas a viable general option in surgery.
Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging
Authors: Ge Xingxing , Liu Xicheng , Tian Zhenzhen , Chen Shujiao , Liu Xinyu , Guo Lihua , Gong Peiwei , Ling Baoping , Yuan Xiang‐Ai , Liu Zhe 
Published: August 2019

Four half‐sandwich rutheniumII (RuII) complexes with triphenylamine‐modifed dipyridine frameworks were synthesized and characterized. The cytotoxicity of target complexes toward A549 (lung cancer cells), HeLa (cervical cancer cells) and HepG2 (hepatoma cells) were obtained by the MTT assay, which were superior to cisplatin with the IC50 values changed from 2.4 ± 0.1 μM to 9.2 ± 2.7 μM. Meanwhile, complexes possess the ability of antimetastasis to cancer cells. RuII complexes could be transported by serum albumin, catalyze the conversion of NADH (the reduced state of nicotinamide‐adenine dinucleotide) to NAD+ and induce the accumulation of reactive oxygen species, which confirmed the antineoplastic mechanism of oxidation. RuII complexes could enter A549 cells followed by a non‐energy dependent cellular uptake mechanism, target lysosomes with the Pearson's colocalization coefficient of 0.75, lead to lysosomal damage, disturb the cell cycle (S phase), and eventually induce apoptosis. The results demonstrate that these RuII complexes are potential anticancer agents with dual functions, including metastasis inhibition and lysosomal damage.
Synthesis of titanium nanoparticles using Allium eriophyllum Boiss aqueous extract by green synthesis method and evaluation of their remedial properties
Authors: Seydi Niloofar , Saneei Sania , Jalalvand Ali R. , Zangeneh Mohammad Mahdi , Zangeneh Akram , Tahvilian Reza , Pirabbasi Elham 
Published: August 2019

The application of nanotechnologies to medicine, or nanomedicine, which has already demonstrated its tremendous impact on the pharmaceutical and biotechnology industries, is rapidly becoming a major driving force behind ongoing developments in the antimicrobial and wound healing fields. This study confirms the potential of Allium eriophyllum Boiss aqueous extract for the green synthesis of titanium nanoparticles (TiNPs). Also, we reveal the antioxidant, cytotoxicity, cutaneous wound healing, antifungal and antibacterial properties of TiNPs. These nanoparticles were characterized using Fourier transform infrared (FT‐IR) and UV–visible spectroscopies, X‐ray diffraction (XRD), transmission electron microscopy (TEM) and field emission scanning electron microscopy (SEM). FT‐IR findings suggested molecular interactions of compounds in the plant were the sources of reducing power, reducing titanium ions to TiNPs. In XRD analysis, 22.8 nm was measured for the crystal size of the nanoparticles. SEM and TEM images indicated a uniform spherical morphology and average diameters of 22 nm. 2,2‐Diphenyl‐1‐picrylhydrazyl experiments were conducted to assess the antioxidant activities, which indicated similar antioxidant potentials for TiNPs and butylated hydroxytoluene. In the antimicrobial part of this study, agar diffusion experiments were done to determine the antibacterial and antifungal characteristics. TiNPs had antifungal activities against Candida guilliermondii, C. krusei, C. albicans and C. glabrata and antibacterial potentials against Gram‐negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium and Escherichia coli O157:H7) and Gram‐positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae and Bacillus subtilis). Also, these nanoparticles did not have any cytotoxicity against human umbilical vein endothelial cells. In in vivo experiments, TiNP ointment significantly decreased (p ≤ 0.01) wound area, total cells, macrophages, neutrophils and lymphocytes and notably increased (p ≤ 0.01) wound contracture, vessels, hydroxyproline, hexosamine, hexuronic acid, fibrocytes and fibrocyte/fibroblast ratio in rats. The results of FT‐IR, UV, XRD, TEM and SEM analyses confirm that aqueous extract of A. eriophyllum leaves can be used to yield TiNPs with notable antioxidant, antibacterial, antifungal and cutaneous wound healing potentials without any cytotoxicity. Further clinical trials are necessary for confirmation of these remedial properties of TiNPs in humans.
Effect of thiocyanate‐based ionic liquids on the dehydrogenation of amine boranes: Experimental and molecular modeling studies
Authors: Kundu Debashis , Chakma Sankar , Pugazhenthi Gopal , Banerjee Tamal 
Published: August 2019

AbstractThe present investigation reports the effect of thiocyanate‐based ionic liquid (IL) on the thermal dehydrogenation of amine boranes. Fifteen ILs based on thiocyanate anion comprising cations from imidazolium, pyrrolidinium, and ammonium family were screened by a priori prediction of infinite dilution activity coefficient using the quantum chemical‐based conductor‐like screening model segment activity coefficient method. The IL with the highest predicted solubility of amine boranes converged to 1‐ethyl‐3‐methylimidazolium thiocyanate ([EMIM][SCN]) that was then used for the dehydrogenation reaction. In the IL medium, ammonia borane (AB) and ethylene diamine bisborane (EDAB) were found to produce ~1.64 equivalent of hydrogen with an induction period of 60 min and ~2.37 equivalent of hydrogen having an induction period of 30 min, respectively. It was observed that the mixture of AB and EDAB in [EMIM][SCN] produced prolonged induction period of 210 min. After 240 min, the mixed amine boranes only produce 0.43 equivalent of H2. To elucidate this slow dynamics, Density Functional Theory (DFT) optimized geometries followed by the natural bond orbital analysis revealed the formation of hydrogen bond between IL and amine borane moiety. Further, the presence of the stronger dihydrogen bond among the protic and hydridic hydrogens was also observed in AB + EDAB/[EMIM][SCN] system, resulting in longer induction period for dehydrogenation.
Thermomechanical recycling of polyamide 6 from fishing nets waste
Authors: Mondragon Gurutz , Kortaberria Galder , Mendiburu Eider , González Nekane , Arbelaiz Aitor , Peña‐Rodriguez Cristina 
Published: August 2019

ABSTRACTThe objective of this work is to analyze the possibility of thermomechanical recycling of polyamide 6 (PA6) from fishing nets waste. The effect of thermomechanical processing on PA yarns obtained from fishing nets waste was investigated by means of physicochemical, rheological, and thermal characterization. Infrared analysis indicated that the chemical composition of samples before and after thermomechanical recycling process was maintained, also confirmed by the thermal transitions detected by calorimetry and the presence of main peaks related to γ and α crystal phases of polyamides at X‐ray diffraction spectra. As rheological and mechanical behavior showed by all recycled samples after processing is similar to those for virgin one, PA obtained from fishing nets waste seems to be valid for recycling, as they can be processed for different potential industrial applications without any remarkable loss of main properties. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48442.
Multicentre observational cohort study of implementation and outcomes of laparoscopic distal pancreatectomy
Authors: Lof S , Moekotte A L , Al-Sarireh B , Ammori B , Aroori S , Durkin D , Fusai G K , French J J , Gomez D , Marangoni G , Marudanayagam R , Soonawalla Z , Sutcliffe R , White S A , Abu Hilal M , Spolentini G , Heijde N , Kanwar A , Schlegel A , Mowbray N G , Rahman S , Kabir I , Deakin M , Bowling K , Khaled Y 
Published: August 2019

Abstract

Background
Laparoscopic distal pancreatectomy (LDP) is increasingly being performed as an alternative to open surgery. Whether the implementation and corresponding learning curve of LDP have an impact on patient outcome is unknown. The aim was to investigate the temporal trends in practice across UK centres.

Methods
This was a retrospective multicentre observational cohort study of LDP in 11 tertiary referral centres in the UK between 2006 and 2016. The learning curve was analysed by pooling data for the first 15 consecutive patients who had LDP and examining trends in surgical outcomes in subsequent patients.

Results
In total, 570 patients underwent LDP, whereas 888 underwent open resection. For LDP the median duration of operation was 240 min, with 200 ml blood loss. The conversion rate was 12·1 per cent. Neuroendocrine tumours (26·7 per cent) and mucinous cystic neoplasms (19·7 per cent) were commonest indications. The proportion of LDPs increased from 24·4 per cent in 2006–2009 (P1) to 46·0 per cent in 2014–2016 (P3) (P &lt; 0·001). LDP was increasingly performed for patients aged 70 years or more (16 per cent in P1 versus 34·4 per cent in P3; P = 0·002), pancreatic ductal adenocarcinoma (6 versus 19·1 per cent; P = 0·005) and advanced malignant tumours (27 versus 52 per cent; P = 0·016). With increasing experience, there was a trend for a decrease in blood transfusion rate (14·1 per cent for procedures 1–15 to 3·5 per cent for procedures 46–75; P = 0·008), ICU admissions (32·7 to 19·2 per cent; P = 0·021) and median duration of hospital stay (7 (i.q.r. 5–9) to 6 (4–7) days; P = 0·002). After 30 procedures, a decrease was noted in rates of both overall morbidity (57·7 versus 42·2 per cent for procedures 16–30 versus 46–75 respectively; P = 0·009) and severe morbidity (18·8 versus 9·7 per cent; P = 0·031).

Conclusion
LDP has increased as a treatment option for lesions of the distal pancreas as indications for the procedure have expanded. Perioperative outcomes improved with the number of procedures performed.
Meta-analysis of recurrence pattern after resection for pancreatic cancer
Authors: Tanaka M , Mihaljevic A L , Probst P , Heckler M , Klaiber U , Heger U , Büchler M W , Hackert T 
Published: August 2019

AbstractBackgroundInitial recurrence mapping of resected pancreatic ductal adenocarcinoma (PDAC) could help in stratifying patient subpopulations for optimal postoperative follow-up. The aim of this systematic review and meta-analysis was to investigate the initial recurrence patterns of PDAC and to correlate them with clinicopathological factors.MethodsMEDLINE and Web of Science databases were searched systematically for studies reporting first recurrence patterns after PDAC resection. Data were extracted from the studies selected for inclusion. Pooled odds ratios (ORs) and 95 per cent confidence intervals were calculated to determine the clinicopathological factors related to the recurrence sites. The weighted average of median overall survival was calculated.ResultsEighty-nine studies with 17 313 patients undergoing PDAC resection were included. The weighted median rates of initial recurrence were 20·8 per cent for locoregional sites, 26·5 per cent for liver, 11·4 per cent for lung and 13·5 per cent for peritoneal dissemination. The weighted median overall survival times were 19·8 months for locoregional recurrence, 15·0 months for liver recurrence, 30·4 months for lung recurrence and 14·1 months for peritoneal dissemination. Meta-analysis revealed that R1 (direct) resection (OR 2·21, 95 per cent c.i. 1·12 to 4·35), perineural invasion (OR 5·19, 2·79 to 9·64) and positive peritoneal lavage cytology (OR 5·29, 3·03 to 9·25) were significantly associated with peritoneal dissemination as initial recurrence site. Low grade of tumour differentiation was significantly associated with liver recurrence (OR 4·15, 1·71 to 10·07).ConclusionRisk factors for recurrence patterns after surgery could be considered for specific surveillance and treatments for patients with pancreatic cancer.
Nanoparticles in the clinic: An update
Authors: Anselmo Aaron C. , Mitragotri Samir 
Published: August 2019

AbstractNanoparticle drug delivery systems have been used in the clinic since the early 1990's. Since that time, the field of nanomedicine has evolved alongside growing technological needs to improve the delivery of various therapeutics. Over these past decades, newer generations of nanoparticles have emerged that are capable of performing additional delivery functions that can enable treatment via new therapeutic modalities. In the current clinical landscape, many of these new generation nanoparticles have reached clinical trials and have been approved for various indications. In the first issue of Bioengineering & Translational Medicine in 2016, we reviewed the history, current clinical landscape, and clinical challenges of nanoparticle delivery systems. Here, we provide a 3 year update on the current clinical landscape of nanoparticle drug delivery systems and highlight newly approved nanomedicines, provide a status update on previous clinical trials, and highlight new technologies that have recently entered the clinic.
Differences in gene expression between high‐grade dysplasia and invasive HPV+ and HPV− tonsillar and base of tongue cancer
Authors: Haeggblom Linnea , Ährlund‐Richter Andreas , Mirzaie Leila , Farrajota Neves da Silva Pedro , Ursu Ramona G. , Ramqvist Torbjörn , Näsman Anders 
Published: August 2019

AbstractBackgroundHuman papillomavirus (HPV) is a causative agent for tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC), as well as for cervical cancer. Premalignant stages in cervical cancer have been studied extensively, while little is known about premalignant stages in TSCC/BOTSCC and the role of HPV. Here we analyzed differences in gene and protein expression between high‐grade dysplasia and invasive cancer in both HPV‐positive (HPV+) and HPV‐negative (HPV−) TSCC/BOTSCC.MethodsHigh‐grade dysplasia and invasive carcinoma were laser microdissected from HPV+ and HPV− TSCC/BOTSCC tumor sections. Differential gene expression was studied utilizing nanoString RNA‐panels and genes of interest were validated on the protein level by immunohistochemistry.ResultsForty genes in the HPV+ tumors showed significantly different expression between high‐grade dysplasia and invasive cancer and 33 genes in the HPV− tumors. Five out of the nine most significant pathways showed similar increased activity in invasive cancer as compared to high‐grade dysplasia in both HPV+ and HPV− tumors. Lastly, significant differences in protein expression was confirmed for SPARC, psoriasin, type I collagen and galectin‐1 in both HPV+ and HPV− tumors.ConclusionsThis is to our knowledge the first study disclosing differences and similarities in gene expression between dysplastic and invasive HPV+ and HPV− TSCC/BOTSCC.
Contemporary suprasternal transcatheter aortic valve replacement: A multicenter experience using a simple, reliable alternative access approach
Authors: Eudailey Kyle W. , Olds Anna , Lewis Clifton T. , Nazif Tamim N. , Vahl Torsten , Khalique Omar K. , Hahn Rebecca T. , Bapat Vinayak , Borger Michael A. , Leon Martin B. , Ahmed Mustafa I. , Kodali Susheel , George Isaac 
Published: August 2019

AbstractObjectivesTo describe outcomes after suprasternal (SS) transcatheter aortic valve replacement (TAVR) as a new alternative access approach.BackgroundThere still remains a cohort of the TAVR population who are not suitable for a transfemoral (TF) approach. SS‐TAVR is a safe and effective alternative to TF‐TAVR and has now become our preferred alternative access route.MethodsWe retrospectively reviewed all patients from New York Presbyterian Hospital, Columbia University Medical Center and Princeton Baptist Medical Center who underwent SS‐TAVR from 2015 to July 2018. A total of 84 patients were included in the study.ResultsTechnical success was achieved in all cases. Thirty‐day survival was 98.8% (n = 83). There were minimal complications. Most notably, there were no transient ischemic attacks or strokes (0%, n = 0). Reexploration for bleeding was 3.6% (n = 3), and major bleeding was 1.7% (n = 1). We also achieved satisfactory results with a mean aortic valve gradient of 6.07 ± 3.79 mmHg and an aortic valve area of 2.21 ± 0.51 cm2. No patients had anything more than mild paravalvular leak. The mean length of stay (LOS) in the intensive care unit was 1.42 ± 1.23 days, and hospital LOS was 4.20 ± 3.29 days.ConclusionsSS access for TAVR is an extremely important technique to have in any valve team's alternative access armamentarium. This technique can be safely and reliably reproduced with any standard hybrid operating room setup and no additional equipment, and it can be used with any commercially available valve system. In the current experience, minimal complications and excellent early term results were obtained.
Effect of Neodymium on the Physico‐chemical Properties and N2O Decomposition Activity of Co(Cu)−Al Mixed Oxides
Authors: Ho Phuoc Hoang , Jabłońska Magdalena , Nocuń Marek , Fornasari Giuseppe , Ospitali Francesca , Vaccari Angelo , Benito Patricia , Palkovits Regina 
Published: August 2019

AbstractCu−Al and Co−Al (M/Al=0.8/0.2, molar ratio; M=Cu or Co) mixed metal oxides showed a moderate activity in N2O decomposition (deN2O) with full conversion at about 500–550 °C. Addition of Nd modified the physico‐chemical and catalytic properties of both Cu−Al and Co−Al materials, though an optimal Nd loading was required. The addition of Nd in Cu0.8Al0.2 and Co0.8Al0.2 with Nd/Co(Cu)/Al = 0.5/0.8/0.2 molar ratio, improved significantly their catalytic activity. In particular, the temperatures needed for full N2O conversion were 100 °C lower than those of the bare materials. Furthermore, the most active Nd0.5Co0.8Al0.2 catalyst exhibited a stable 60 % N2O conversion at 450 °C for 50 h in presence of NO (200 ppm), O2 (20,000 ppm) and H2O (2500 ppm). The enhancement in the activity of both Cu‐ and Co‐containing materials was related to the formation of CuNd2O4 for Nd0.5Cu0.8Al0.2 and NdCoO3 for Nd0.5Co0.8Al0.2. The presence of CuNd2O4 or NdCoO3 accounted for changes in redox properties, e. g., easier reduction or faster release of oxygen, and in turn an increased catalyst activity in deN2O. The investigation of rare earth‐based catalysts for deN2O is limited in the scientific literature, while a comprehensive understanding of the involved active species may facilitate a knowledge‐based catalyst optimization.
Synthesis of Erythrocyte‐Like P2‐Type Na0.67Mn0.75Co0.25O2 for Sodium Storage
Authors: Cong Xiaotong , Shen Jianxing , Wang Tailin , Chen Pan 
Published: August 2019

AbstractSodium‐ion batteries are the most promising next‐generation energy storage systems. Nevertheless, low capacity and short cycle life have hindered their industrial production. Herein, we synthesized novel erythrocyte‐like Na0.67Mn0.75Co0.25O2 cathode materials through a simple co‐precipitation and solid‐phase method. The material has an erythrocyte morphology, which is different from the typical angular hexagonal morphology. The Na0.67Mn0.75Co0.25O2 cathode materials have a preeminent discharge capacity of 198 mAh g−1 at 50 mA g−1 within a voltage range of 1.5–4.3 V and superior cycling and rate performance. The superior performance of the cathode materials is ascribed to the erythrocyte‐like morphology and the layered structure that mitigate the stress and expedite the transfer of sodium ions. The Na0.67Mn0.75Co0.25O2 cathode materials with erythrocyte‐like morphology have great potential for industrial production.
More than Proton Detection—New Avenues for NMR Spectroscopy of RNA
Authors: Schnieders Robbin , Keyhani Sara , Schwalbe Harald , Fürtig Boris 
Published: August 2019

AbstractRibonucleic acid oligonucleotides (RNAs) play pivotal roles in cellular function (riboswitches), chemical biology applications (SELEX‐derived aptamers), cell biology and biomedical applications (transcriptomics). Furthermore, a growing number of RNA forms (long non‐coding RNAs, circular RNAs) but also RNA modifications are identified, showing the ever increasing functional diversity of RNAs. To describe and understand this functional diversity, structural studies of RNA are increasingly important. However, they are often more challenging than protein structural studies as RNAs are substantially more dynamic and their function is often linked to their structural transitions between alternative conformations. NMR is a prime technique to characterize these structural dynamics with atomic resolution. To extend the NMR size limitation and to characterize large RNAs and their complexes above 200 nucleotides, new NMR techniques have been developed. This Minireview reports on the development of NMR methods that utilize detection on low‐γ nuclei (heteronuclei like 13C or 15N with lower gyromagnetic ratio than 1H) to obtain unique structural and dynamic information for large RNA molecules in solution. Experiments involve through‐bond correlations of nucleobases and the phosphodiester backbone of RNA for chemical shift assignment and make information on hydrogen bonding uniquely accessible. Previously unobservable NMR resonances of amino groups in RNA nucleobases are now detected in experiments involving conformational exchange‐resistant double‐quantum 1H coherences, detected by 13C NMR spectroscopy. Furthermore, 13C and 15N chemical shifts provide valuable information on conformations. All the covered aspects point to the advantages of low‐γ nuclei detection experiments in RNA.
Proton Thermodynamics in a Protic Ionic Liquid, Ethylammonium Nitrate
Authors: Kanzaki Ryo , Kodamatani Hitoshi , Tomiyasu Takashi 
Published: August 2019

AbstractIn order to investigate the proton solvation state in protic ionic liquids (PILs), ten acid dissociation enthalpies and entropies of eight compounds were determined in ethylammonium nitrate (EAN). Regardless of the nature of the compound, 24 kJ mol−1 larger enthalpy and 65 J mol−1 K−1 larger entropy than those in water, respectively, were observed. These values were reasonably explained by the differences in the proton solvation structure in EAN and water. Namely, protons in EAN exist as HNO3, having a higher reaction energy than that of H3O+ in water, undergo entropic stabilization as a result of the less‐structured solvation. As such, the entropic effect of the proton solvation structure on the acid–base property is possibly applicable to all PILs. In addition, based on these proton thermodynamics, enthalpy and entropy windows were proposed as a novel perspective for the characterization of solvents. Use of this concept enabled the visualization of similarities and differences between EAN and water.