bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a Trauma‐Informed Comprehensive School Physical Activity Program: Specifying Feasible Practices Across the School Day
Authors: Kroshus‐Havril Emily , Hafferty Kiana , Massey William V. , Whitley Meredith A. , Darroch Francine , Shaikh Majidullah , Ellison Douglas W. , Moore Adrienne , Garrett Kimberly , Tandon Pooja S. 
Published: November 2024

AbstractBackgroundMany students would benefit from trauma‐informed physical activity (PA); however, there is a lack of systematic guidance on incorporating trauma‐informed practices across school‐based PA opportunities. The purpose of this study was to generate a feasible framework for trauma‐informed school‐based PA.MethodsFramework development was guided by a modified Delphi approach, including an exploration phase and an evaluation phase. First, a multidisciplinary working group reviewed extant literature, mapping trauma‐informed practices onto the domains and components of the Comprehensive School Physical Activity Program (CSPAP). Subsequently, experts (n = 14) provided quantitative feedback on the utility and feasibility of these practices.ResultsThirty‐three practices met pre‐determined thresholds for utility and feasibility. Across CSPAP domains, this included attending to: (a) safety; (b) positive communication and relationships; (c) empowerment, choice, and voice; (d) emotion management and skill building; (e) instructor competencies and support; and (f) cultural, historical, and gender issues.Implications for School Health Policy, Practice, and EquityIncorporating trauma‐informed practices into existing frameworks and approaches to school‐based PA may promote uptake of practices that help meet the social and emotional needs of trauma‐exposed youth.ConclusionsThe present output provides a foundation for generating tools and supports for incorporating trauma‐informed practices into school‐based PA promotion efforts.
Communication design logics and innovation management
Authors: Ludwig Stephan , Herhausen Dennis , De Luca Luigi , Grewal Dhruv 
Published: November 2024

AbstractEffective communication with external or internal stakeholders is crucial for innovation processes. The fourth wave of digital technologies and the fifth industrial revolution have increased the range of communication possibilities, amplifying both the number of communication channels and the availability of data. Yet in existing research that tends to treat communication as an art instead of a science, the evidence only scratches the surface of its mechanics and inner logic. To provide a unified theoretical framework, this study highlights the importance of the four pillars of communication design logic (source, situation, intentions, and impact) in the innovation processes. According to communication theories, individual differences in stakeholders' backgrounds, situations, and intentions might result in systematic variations in what and how they communicate, which influences their subsequent beliefs and reactions to innovation outcomes. By examining relevant communications in terms of their design logic, innovation researchers can address a wide range of questions across ideation, development, and implementation stages. Using novel techniques and unstructured data (e.g., text, image, video, audio mining), the current study reveals tactics for exploring such topics across communication types. The proposed framework also raises several research questions that can be pursued to enhance knowledge of how communication design influences innovation management.
Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele
Authors: Nagao Itsuma , Motegi Tomoki , Goto‐Koshino Yuko , Tsuboi Masaya , Takahashi Naohiro , Chambers James K. , Uchida Kazuyuki , Baba Kenji , Tomiyasu Hirotaka , Okuda Masaru 
Published: November 2024

AbstractBackgroundGallbladder mucocele (GBM) is a common disease in the canine gallbladder. Although the pathogenesis of GBM remains unclear, we recently reported that the excessive accumulation of mucin in the gallbladder is not a result of overproduction by gallbladder epithelial cells (GBECs).Hypothesis/ObjectivesChanges in the function of GBECs other than the production of mucin are associated with the pathogenesis of GBM. We performed an RNA sequencing (RNA‐seq) analysis to comprehensively search for abnormalities in gene expression profiles of GBECs in dogs with GBM.AnimalsFifteen dogs with GBM and 8 dogs euthanized for reasons other than gallbladder disease were included.MethodsThe GBECs were isolated from gallbladder tissues to extract RNA. The RNA‐seq analysis was performed using the samples from 3 GBM cases and 3 dogs with normal gallbladders, and the gene expression profiles were compared between the 2 groups. Differences in mRNA expression levels of the extracted differentially expressed genes (DEGs) were validated by quantitative reverse transcription polymerase chain reaction (RT‐qPCR) using samples of 15 GBM cases and 8 dogs with normal gallbladders.ResultsComparison of gene expression profiles by RNA‐seq extracted 367 DEGs, including ANO1, a chloride channel associated with changes in mucin morphology, and HTR4, which regulates the function of chloride channels. The ANO1 and HTR4 genes were confirmed to be downregulated in the GBM group by RT‐qPCR.Conclusions and Clinical ImportanceOur results suggest that GBM may be associated with decreased function of chloride channels expressed in GBECs.
The state of the art and future of climate risk insurance modeling
Authors: Ingels Michiel W. , Botzen W. J. Wouter , Aerts Jeroen C. J. H. , Brusselaers Jan , Tesselaar Max 
Published: November 2024

AbstractThis study provides a comprehensive review of the literature on climate risk insurance modeling to identify lessons learned and knowledge gaps to be addressed by future research. These models are increasingly relevant due to the rising losses attributable to climate change. Insurance models estimate risk for different perils and simulate risk‐related parameters for insurance schemes, such as premiums and deductibles. Most forward‐looking models indicate that climate change and socioeconomic developments highly exacerbate future risk and increase insurance premiums. Various studies recommend charging risk‐based premiums to incentivize adaptation efforts that limit this increase in climate risks. Other findings point toward introducing public–private insurance to cope with climate change and enhance risk spreading by introducing insurance purchase requirements or insurance products that cover multiple climate risks. Gaps that we identify in this literature include an underrepresentation of insurance assessments for developing countries and for hazards other than flooding. Additionally, we note a lack of research into insurance for non‐agricultural commercial sectors. Furthermore, less than half of the studies take a forward‐looking approach by incorporating climate change scenarios, and an even smaller percentage consider socioeconomic development scenarios. This limitation shows that current methods require additional development for assessing the effects of future climate risk on insurance. We recommend that future research develops such forward‐looking models, considers using a more refined spatial scale, broadens geographical and hazard coverage, and includes the commercial sector.
“Vulva,” Not “Private Part”: The Importance of Accurate Genital Terminology
Authors: Chang Hannah R. , Ngo Madeline , Mauskar Melissa M. , Marathe Kalyani S. 
Published: November 2024

ABSTRACTEffective communication in pediatric dermatology is critical for accurate diagnosis and treatment, particularly in sensitive areas such as the anogenital region. Unfortunately, children and their families often use euphemisms or incorrect terms when referring to this area, and many adults lack knowledge of anogenital terminology. Pediatric dermatologists can play a unique role in educating children and their families on correct anatomical language, which enhances body awareness, empowers young patients, improves safety, and contributes to accurate medical assessments and treatment adherence. By promoting the use of correct anatomical terms, pediatric dermatologists can improve patient outcomes and foster a healthier understanding of body anatomy and health.
Food Allergy Test‐Guided Dietary Advice for Children With Atopic Dermatitis: A Consensus Study
Authors: Garside Ludivine , Boyle Robert , Meyer Rosan , Skypala Isabel , Allen Hilary , Beattie Paula , Dempsey Justine , Doyle Matt , Evans‐Howells Helen , Feeney Mary , Ludman Siân , Marrs Tom , Ravenscroft Jane , Stiefel Gary , Umasunthar Thisanayagam , Vyas Deepan , Yerlett Natalie , Walsh Jo , Brown Sara J. , Ridd Matthew J. 
Published: November 2024

ABSTRACTBackgroundThe use of blood specific IgE or skin prick tests (SPT) to guide dietary exclusions for disease control in children with atopic dermatitis (AD) is controversial. We undertook a consensus exercise on how to interpret SPT results and dietary history for cow's milk, hen's egg, wheat, and soy in children < 2 years old with AD.MethodsFourteen clinicians from general practice, pediatrics, pediatric dermatology, pediatric allergy, and pediatric dietetics from UK and Ireland took part in an online modified Delphi study. Over three rounds, participants gave their anonymous opinions and received individualized and group feedback, based on the premise that all children had SPTs. The findings were discussed in an online workshop.ResultsOf 18 symptoms, 12 were identified as relevant to immediate and 7 to delayed allergy. Regarding SPTs, there was consensus over which allergens to use for wheat and soy but not cow's milk or hen's egg; for all study foods, wheal size was determined as 0–1 mm negative, ≥ 5 mm sensitized, but between 2 and 4 mm, categorization varied by food. During the final workshop, consensus was reached on dietary advice for nine combinations of SPT results and dietary history.ConclusionWe attained consensus on how SPTs and dietary history for four common food allergens should be interpreted in young children under 2 years of age with AD. These pragmatic recommendations may support clinician education, consistency of decision‐making, and future research.
Simone Weil and Ludwig Wittgenstein: ‘Philosophy as work on oneself’
Authors: Springsted Eric O. 
Published: November 2024

AbstractFor many years Simone Weil and Ludwig Wittgenstein have been placed side by side. Little of that work has tried to explicitly compare the two. Direct comparisons can, however, be made between Weil and Wittgenstein, which can show that the ways they approached philosophy shared numerous traits and ideas. Both thinkers rejected philosophical systems, both admitted that serious philosophical work did not try to reject all contradictions internal to it, and, in fact, both sought to make facing contradictions and seeming contradictions central to their method. Both wrote of the world with a sense of mystery that surrounds human life, a sense of transcendent good. Both engaged the problems with talking about such a good that cannot be neatly fit into language. Both also saw the task of philosophy as one concerned with meaning. Both also saw philosophy as a matter of “work on oneself.” This essay will examine what it means to say that philosophy is a matter of work on oneself. To do so, I want to examine primarily two essays, one from each philosopher, essays which bear remarkable similarity to each other in the sort of problem they deal with.They are section xi of Wittgenstein's Philosophy of Psychology – A Fragment, and Weil's “Essay on the Concept of Reading.”
Will climate change constrain the altitudinal range of threatened species? Experimental evidence from a biodiversity hotspot
Authors: de Souza A. C. , Pires A. S. , Donohue K. , de Mattos E. A. 
Published: November 2024

Abstract
A fundamental goal in ecology and evolution is to explain the factors that shape species' abundance and range limits. Evaluating the performance of early life‐stages across an altitudinal gradient can be valuable for understanding what factors shape range limits and for predicting how plant species may respond to climate change.
To experimentally evaluate the presence of local adaptation in a threatened palm (Euterpe edulis) at early life‐stages, we reciprocally sowed seeds at two contrasting elevations. In addition, to evaluate the effect of seed predation on E. edulis seed germination and seedling establishment, seed addition experiments were conducted at three different elevations.
Our results showed no evidence of local adaptation in the early life‐stages for the two E. edulis populations. We observed lower germination and seedling performance of both E. edulis populations at the low‐elevation site. The exclusion of seed predation increased seedling establishment across all elevations. Seed predation and dry soil conditions were the main factors that constrained seedling establishment at the upper altitudinal limit and at the lower elevation, respectively.
Climate change in the study area will result in warmer and drier environmental conditions. The lack of local adaptation and the lower performance of both E. edulis populations in warm and dry conditions, combined with a higher seed predation at the upper altitudinal limit, might cause an altitudinal range contraction, increasing the vulnerability of this threatened species to climate change.
Metabolome and transcriptome reveal the biosynthesis of flavonoids and amino acids in Isatis indigotica fruit during development
Authors: Huang Hui , Zhang Li , Guan Liye , Zhang Libin 
Published: November 2024

AbstractIsatis indigotica Fort. is a famous medicinal plant that is also used as a natural dye and functional vegetable. The characteristics of the I. indigotica fruit during development are largely unknown, information that is essential for the exploitation and seedlings cultivation of I. indigotica. In this study, the biochemical, metabolite characteristics and gene expression profiling of I. indigotica at four developmental stages were investigated. A total of 428 metabolites were detected and categorized into 17 categories. High contents of anthocyanins, especially cyanidin 3‐glucoside, might contribute to the purple colouration of I. indigotica fruits. Moreover, dozens of flavonoid components, including taxifolin, quercetin, astragalin and isovitexin 2″‐O‐beta‐D‐glucoside, and several other active components were also up‐regulated in mature fruits. The abundance of antioxidants might endow a significantly stronger antioxidant activity of mature I. indigotica fruits compared to many other reported species. Enrichment analyses revealed that flavonoid and anthocyanin biosynthesis genes were mostly enriched in up‐regulated gene sets during fruit development. The up‐regulated structural genes, including IiCHS, IiCHI, IiF3H, IiDFR, IiANS, IiFLS, IiUGT, and transcription factors such as IiMYBs, IibHLHs and IiNACs were identified as candidate regulators of flavonoid and anthocyanin biosynthetic pathway. Furthermore, biosynthesis of amino acids was enriched in all pairwise comparisons of metabolites in fruits at four developmental stages. The differential accumulation of amino acids might result from the differentially expressed genes involved in amino acid biosynthesis. Taken together, these findings provide a comprehensive understanding of metabolite profiling and gene expression patterns in I. indigotica fruit during maturity, which is useful for pharmaceutical extractions and seedling cultivation of I. indigotica.
Genetic and epigenetic control of dormancy transitions throughout the year in the monoecious cork oak
Authors: Silva Helena Gomes , Sobral Rómulo , Alhinho Ana Teresa , Afonso Hugo Ricardo , Ribeiro Teresa , Silva Patrícia M. A. , Bousbaa Hassan , Morais‐Cecílio Leonor , Costa Maria Manuela Ribeiro 
Published: November 2024

AbstractBud dormancy plays a vital role in flowering regulation and fruit production, being highly regulated by endogenous and environmental cues. Deployment of epigenetic modifications and differential gene expression control bud dormancy/break cycles. Information on how these genetic and epigenetic mechanisms are regulated throughout the year is still scarce for temperate trees such as Quercus suber. Here, the expression levels of CENTRORADIALIS‐LIKE (CENL) and DORMANCY‐ASSOCIATED PROTEIN 1 (QsDYL1) during seasonal cycles of bud development, suggesting that QsCENL may be implicated in growth cessation in Q. suber and that QsDYL1 is a good dormancy marker. As gene expression can be regulated by the activity of chromatin modifiers, we have analysed the expression of these genes and the deposition of epigenetic marks in dormant versus non‐dormant bud meristems. The DNA methyl transferases CHROMOMEHTYLASE 3 (QsCMT3) and METHYLTRANSFERASE 1 (QsMET1) were more expressed in the transition between dormancy to bud swelling. QsCMT3 was also highly expressed during the late stages of active bud formation. Conversely, the HISTONE ACETYLTRANSFERASE 1 (QsHAC1) was up‐regulated during growth cessation and dormancy when compared to bud swelling. These results indicate that epigenetic regulation is implicated in how bud development progresses in Q. suber, which can be observed in the different profile deposition of the repressive and active marks, 5mC and H3K18Ac/H3K4me, respectively.The identification of bud‐specific genetic and epigenetic profiling opens new possibilities to predict the relative rate of dormancy/growth of the bud stages, providing tools to understand how trees respond to the current challenges posed by climate change.
Predictive Indicators of Cryotolerance and Fertility in Bovine Sperm: Evaluating Fresh Semen Quality to Improve AI Outcomes With Frozen–Thawed Sperm
Authors: Tamargo Carolina , Garriga Ferran , Yeste Marc , Pinart Elisabeth , Muiño Rodrigo , Carbajo María Teresa , Hidalgo Carlos Olegario 
Published: November 2024

ABSTRACTThe success of artificial insemination (AI) with frozen–thawed semen in cattle is influenced by both female factors and sperm quality. In terms of sperm quality, prior studies indicate that the ability of frozen–thawed bovine sperm to fertilise an oocyte is dependent on their quality and resilience to cryopreservation. Cryopreservation induces oxidative stress, leading to ultrastructural damage in the sperm. This study aimed to determine whether the quality of fresh semen can identify bulls with good and poor sperm freezability. This difference between fresh and frozen semen from the same bull allows us to predict fertility. Motility and kinetic parameters were assessed using computer‐assisted sperm analysis (CASA), while six functional variables were evaluated through flow cytometry, both before and after the freeze–thaw process on the sperm from 13 bulls. In vivo fertility was measured using 90‐day non‐return rates. The principal component analysis (PCA) of eight sperm variables post‐thaw identified one principal component explaining 81.19% of the total variance and classified the bulls into two groups: Poor freezability bulls (progressive motility: 48.12% ± 8.41%; viability: 77.51% ± 7.61%) and good freezability bulls (progressive motility: 58.64% ± 6.64%; viability: 88.12% ± 2.52%). Bulls with higher freezability showed better sperm viability and motility, as well as lower levels of ROS, superoxides and intracellular calcium before cryopreservation that were significantly correlated with higher non‐return rates (NRR). The results underscore the importance of assessing the quality and functionality of fresh semen to predict the fertility potential of cryopreserved sperm. This approach can aid in selecting ejaculates with the best potential for successful artificial insemination, ultimately improving reproductive performance in dairy cattle.
The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes
Authors: Mills Richard , Merz Eva‐Maria , Croucher Mark , Masser Barbara , Brailsford Susan R. , Smith Robert , Ferguson Eamonn 
Published: November 2024

AbstractBackgroundThe UK's Infected Blood Inquiry (IBI) highlighted a major public health scandal, with at least 30 000 people infected and more than 3000 deaths attributable to infected blood and blood products. This study investigates the impact of the IBI announcement on May 20, 2024, on public perceptions of blood supply risk, safety, and donation intentions in the UK compared to the USA.MethodsA 2 (country: UK vs. USA) × 2 (time: pre‐, post‐IBI announcement) between‐within‐subject study was conducted with 1635 participants (888 UK, 747 USA). Pre‐IBI data were collected from May 3 to 7, 2024, and post‐IBI data from May 30 to June 30, 2024. Key measures were perceived infection risk from transfusion, transfusion safety, willingness to donate and encourage others. The impact was assessed using differences‐in‐differences (DiD) and reliable‐change‐indices (RCI).ResultsUK participants showed a significant but small decrease in perceived safety compared to USA participants, with 1 in 30 UK individuals perceiving a significant reduction in perceived transfusion safety. Decreases in perceived safety were associated with significant decreases in willingness to donate and encouragement of others in the whole sample and in USA participants and significant decreases in willingness to encourage others in UK participants. Older people reported a greater reduction in safety, and non‐donors were more likely to be put off donating and not ask others to donate as a result of their perception that safety had been reduced.ConclusionOverall, perceived safety decreased marginally in the UK general population. Future research should explore the long‐term impacts of the IBI.
Fear of donation‐related stimuli across different levels of donation experience and types of donation (whole‐blood and plasma): A cross‐sectional study in Italian donors
Authors: Bani Marco , Ardenghi Stefano , Russo Selena , Zorzi Federico , Rampoldi Giulia , Del Greco Alexia , Giussani Barbara , Danesi Daniela , Strepparava Maria Grazia 
Published: November 2024

AbstractBackgroundDonation‐related fears are prevalent even among regular donors and can hinder both recruitment and retention. This cross‐sectional study aimed to estimate the prevalence of these fears in Italian whole‐blood and plasma donors, across different levels of donation experience.Study Design and MethodsA sample of 615 voluntary, unpaid donors from Italy (64.1% male, mean age 45.42 ± 11.80 years) completed an online survey assessing their fear of common donation‐related stimuli (fear of blood, needles, pain, and fainting), experience of vasovagal symptoms at the last donation, and their intention to donate again. Donors were grouped based on donation history and their most recent donation type (whole‐blood or plasma).ResultsA significant negative relationship was found between donation history and most types of donation‐related fears, suggesting that greater experience corresponds to reduced fear. Plasma donors reported lower levels of fear across all stimuli compared to whole‐blood donors. Despite this, nearly one‐third of the most experienced whole‐blood donors and 20% of plasma donors still reported some level of fear. Greater fear was associated with increased reports of pain and vasovagal symptoms during donation, regardless of donation type. However, no significant association emerged between donation‐related fears and the intention to donate again.DiscussionDonation‐related fear persists even among experienced donors, for both whole‐blood and plasma donors. Given its potential to impact donor comfort and retention, the assessment and management of donation‐related fears should be integrated into donor care, with appropriate strategies to help donors regulate their fear throughout their donation careers.