bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent vertebral fractures in a young adult: a closer look at bone health in type 1 diabetes mellitus
Authors: Thong Eleanor P , Catford Sarah , Fletcher Julie , Wong Phillip , Fuller Peter J , Teede Helena , Milat Frances 
Published: May 2018

Summary
The association between type 1 diabetes mellitus (T1DM) and bone health has garnered interest over the years. Fracture risk is known to be increased in individuals with T1DM, although bone health assessment is not often performed in the clinical setting. We describe the case of a 21-year-old male with longstanding T1DM with multilevel vertebral fractures on imaging, after presenting with acute back pain without apparent trauma. Dual-energy X-ray absorptiometry (DXA) revealed significantly reduced bone mineral density at the lumbar spine and femoral neck. Extensive investigations for other secondary or genetic causes of osteoporosis were unremarkable, apart from moderate vitamin D deficiency. High-resolution peripheral quantitative computed tomography and bone biospy revealed significant alterations of trabecular bone microarchitecture. It later transpired that the patient had sustained vertebral fractures secondary to unrecognised nocturnal hypoglycaemic seizures. Intravenous zoledronic acid was administered for secondary fracture prevention. Despite anti-resorptive therapy, the patient sustained a new vertebral fracture after experiencing another hypoglycaemic seizure in his sleep. Bone health in T1DM is complex and not well understood. There are significant challenges in the assessment and management of osteoporosis in T1DM, particularly in young adults, where fracture prediction tools have not been validated. Clinicians should be aware of hypoglycaemia as a significant risk factor for fracture in patients with T1DM.

Learning points:

Type 1 diabetes mellitus (T1DM) is a secondary cause of osteoporosis, characterised by reduced bone mass and disturbed bone microarchitecture.

Hypoglycaemic seizures generate sufficient compression forces along the thoracic column and can cause fractures in individuals with compromised bone quality.

Unrecognised hypoglycaemic seizures should be considered in patients with T1DM presenting with fractures without a history of trauma.

Patients with T1DM have increased fracture risk and risk factors should be addressed. Evaluation of bone microarchitecture may provide further insights into mechanisms of fracture in T1DM.

Further research is needed to guide the optimal screening and management of bone health in patients with T1DM.
Sexual Risk Outcomes of an Emotion Regulation Intervention for At-Risk Early Adolescents
Authors: Houck Christopher D. , Barker David H. , Hadley Wendy , Menefee Maya , Brown Larry K. 
Published: May 2018

OBJECTIVE:
With this study, we examined the efficacy of a health intervention program that was focused on emotion regulation (ER) skills in reducing sexual risk behaviors among early adolescents with suspected mental health symptoms.

METHODS:
Seventh grade adolescents with suspected mental health symptoms participated in a 6-week, after-school sexual risk prevention trial in which a counterbalanced, within-school design comparing an ER focused program to a time- and attention-matched comparison group was used. Adolescents completed a computer-based survey regarding their sexual behavior at 6-month intervals for 2.5 years.

RESULTS:
Adolescents who received ER skills training exhibited a delay in the transition to vaginal sex over 30 months compared with those in the comparison condition (adjusted hazard ratio = 0.61; 95% confidence interval [0.42 to 0.89]). They also reported fewer instances of condomless sex over the follow-up period (adjusted rate ratio = 0.36; 95% confidence interval [0.14 to 0.90]). Among those who were sexually active, those in the ER condition reported fewer instances of vaginal or anal sex (adjusted rate ratio = 0.57; 95% confidence interval [0.32 to 0.99]).

CONCLUSIONS:
An intervention used to teach ER skills for the context of health decision-making resulted in lower risk among young adolescents with suspected mental health symptoms by delaying the onset of vaginal sex as well as reducing penetrative acts without a condom. Incorporating emotion education into health education may have important health implications for this age group.
PROGNOSTIC SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION MARKERS IN ARTERIAL HYPERTENSION
Authors: Podzolkov V. I. , Bragina A. E. , Bragina N. A. 
Published: May 2018

Aim. Assessment of prognostic significance of endothelial dysfunction markers: stable metabolites of nitric oxide (NOx), von Willebrand factor (vWF), endothelin-1 (E1), homocysteine and tissue plasminogen activator (tPA) in essential hypertension (EAH) patients not taking antihypertension therapy systematically.Material and methods. Totally, 12 EAH patients investigated (45 males, 79 females) (mean age 51,4±6,5 y. o., mean duration of AH 7,9±7,3 y.). Concentration of NOx in plasma was measured by spectrophotometry, and of vWF, homocysteine, E1 and tPA — by immune enzyme assay.Results. By the increase of SCORE risk level, there was significant increase of concentrations of NOx, E1, homocysteine and vWF in EAH patients (p<0,05), there were no changes in tPA levels (p>0,05). In 8 (8±1,1) years after baseline assessment, 115 patients were assessed second time. Of those 13 (11,3%) had cardiovascular events (CVE) and 5 (4,3%) died. By single factorial regression, the rate of CVE in EAH patients relate to homocystein level (р=0,01), NOx (р=0,001) and vWF (р=0,001). By multifactorial analysis, prognostic statistical significance is found for NOx (relative risk (RR) =3,8, р=0,006) and vWF (RR =3,5, р=0,005). In ROC-analysis there were found threshold levels of NOx (>46,6 mcM/L, AUC =0,863) and vWF (>1,68 mg/dL, AUC =0,738), the increase of which is followed by CVE development risk for the levels of NOx >46,6 mcM/L 3,8 times (sensitivity 81,9% and specificity 65,8%), vWF >1,68 mg/dL — 3,5 times (sensitivity 74,3% and specificity 62,7%). Combination of the parameters point on the risk increase up to 6,5 times (р=0,00007).Conclusion. NOx with the threshold of >46,6 mcM/L (RR =3,8) and vWF >1,68 mg/dL (RR =3,5) do show independent prognostic value for 5-year CVE risk assessment in EAH patients that can be applied as an additional method for risk stratification to estimate a group for more aggressive therapy and CVE prevention.
A Comparison of Mothers Upbringing Methods Based on Adolescents Intelligence Groups (High-Intelligence, Low-Intelligence and Normal)
Authors: Kalantari Masume , Barati Fakhr Sadat , Tahan Mohammad 
Published: May 2018

This research has been designed to compare mothers upbringing methods based on adolescents intelligence groups; high-intelligence, low-intelligence and normal. To this purpose, 194 individuals were chosen from among male and female students of ages 14 and 15 from the city of Ghaenat from southern Khorasan province within the educational year of 2015, by the simple-random method in high-intelligence schools, by the census method in low-intelligence schools and by the multi-stage cluster sampling method in normal schools. The tools employed include the Bamrind questionnaire on upbringing methods. Pierson’s codependence coefficient and multi-variant variance analysis have been used for data analysis.
Results indicated that the difference is significant between intelligence groups regarding tyrannical and logical potency and no significant difference in upbringing methods based on freedom. There is positive and significant difference between mothers of children belonging to high and low-intelligence groups regarding authoritarian and logical potency, and mothers of children belonging to the normal and low-intelligence groups. There’s no significant difference between other intelligence groups and upbringing methods.
Социально-философские проблемы демографии. Круглый стол «Вопросов философии» (1974)
Authors: «Демографическое обозрение» Редакция журнала 
Published: May 2018

Перепечатка стенограммы выступлений на заседании Круглого стола, проходившего 7—8 мая 1974 года в редакции журнала «Вопросы философии» и посвященного обсуждению социально-философских проблем демографии. 1974 год был объявлен ООН «Годом мирового населения», в августе 1974 г. был проведен Международный конгресс по проблемам демографии в Бухаресте. В целом же 1970-е годы прошлого века стали важным этапом, в ряде случаев – поворотным пунктом как в эволюции основных демографических процессов, так и в развитии мировой демографической мысли. Материалы Круглого стола дают представление об уровне осмысления демографической реальности, основных демографических тенденций и их движущих сил в советской науке того времени. Они позволяют судить о соотношении объективного научного и заданного идеологического компонентов во взглядах участников Круглого стола. Обсуждение было междисциплинарным, в нем приняли участие демографы, философы, социологи, экономисты, этнологи, биологи, юристы.
В Круглом столе приняли участие:

И.Т. Фролов
Я.Н. Гузеватый
А.Г. Вишневский
А.Я. Кваша
Н.П. Бочков
В.А. Болдырев
В.И. Переведенцев
В.И. Козлов
Л.Е. Дарский
И.Л. Андреев
М.М. Бабаев
В.П. Эфроимсон
В.А. Геодакян
О.Б. Осколкова
Б.С. Ерасов
В.В. Пациорковский
Г.И. Герасимов
Призрение детей в воспитательных домах
Authors: Яблоков Николай Викентьевич 
Published: May 2018

Воспроизводится работа Николая Викентьевича Яблокова (1845–1904 гг.), опубликованная им в 1901 году и удостоенная похвального отзыва на первом конкурсе на соискании премии Императрицы Александры Федоровны. Поводом, побудившим Н.В. Яблокова написать данные очерк, стало, в том числе, обращение внимания императора Александра III на высокую смертность детей в Московском и Санкт-Петербургском Воспитательных домах и, как результат, последовавшие значительные изменения в правилах функционирования этих Воспитательных домов (Указ 1891 г.).
Вначале Н.В. Яблоков обращается к истории отношения государства и общества к вытравливанию плода, детоубийству и подкидыванию незаконнорожденных детей в период, предшествующий созданию первого воспитательного дома в Милане в 767 году; а затем подробно останавливается на развитии воспитательных домов и тайных приемных корзин («tour») в католической Европе (в протестантских странах открытие воспитательных домов признавалось безнравственным).
Большая часть очерка посвящена организации помощи сиротам и незаконнорожденным детям в России в «сиропитомцах», «сиропитомских госпиталях», создававшихся при церквях вначале по частной инициативе, а позднее – по поручению Петра I, и наконец в учрежденном манифестом Екатерины II в 1763 году первом Воспитательном доме в Москве, а в 1771 году – втором в Санкт-Петербурге. Н.В. Яблоков подробно рисует картину функционирования воспитательных домов, в том числе правил и особенностей приема и призрения в них детей. Отельное внимание уделяется положительным и отрицательным сторонам явного и тайного приема младенцев (до 1891 г. прием в Воспитательные дома был тайный).
Н.В. Яблоков закончил медицинский факультет Московского университета, доктор медицины, работал врачом в грудных отделениях Московского Воспитательного дома и главным врачом в Софийской детской больнице (ныне - Детская городская клиническая больница № 13 имени Н. Ф. Филатова); активно занимался организационными вопросами, связанными с охраной здоровья детей и их социальной защитой.
KİTAP DEĞERLENDİRME/BOOK REVİEW : BAŞLANGIÇTAN HALKEVLERİNE TRABZON’DA TİYATRO
Authors: KÖKSAL Ülkü 
Published: May 2018

Kitap Değerlendirme/Book Review:&nbsp;

Veysel Usta-Ömer İskender Tuluk,
BAŞLANGIÇTAN HALKEVLERİNE TRABZON’DA TİYATRO, Serander Yayınevi, Trabzon 2017, 344
s. ISBN: 978-605-2104-01-9
Osteoarticular Allograft Transplantation of the Trochlear Groove for Trochlear Dysplasia
Authors: DePhillipo Nicholas N. , Kennedy Mitchell I. , Aman Zachary S. , Moatshe Gilbert , LaPrade Robert F. 
Published: May 2018

Case:
A 21-year-old woman with recurrent lateral patellar instability caused by severe trochlear dysplasia and concomitant grade-IV trochlear chondromalacia was treated successfully with osteoarticular allograft transplantation of the entire trochlear groove.

Conclusion:
The treatment of chronic lateral patellar instability caused by trochlear dysplasia can be challenging. When nonoperative treatment is unsuccessful, a sulcus-deepening trochleoplasty may be indicated. However, contraindications for a trochleoplasty include grade-IV chondromalacia of the patellofemoral joint. Even with this contraindication, an osteoarticular allograft transplant of the trochlear groove can serve as a salvage procedure to improve knee function.
Soil‐Test Biological Activity with the Flush of CO2: III. Corn Yield Responses to Applied Nitrogen
Authors: Franzluebbers Alan J. 
Published: May 2018

Core Ideas
Relative corn yield was associated with residual inorganic and mineralizable N.
Soil‐test biological activity was a good surrogate for predicting N availability.
Economically optimum N fertilizer requirement could be adjusted with soil testing.
Corn (Zea mays L.) is an important cereal grain in many states and typically receives large N fertilizer inputs, irrespective of historical management. Tailoring N inputs to soil‐specific conditions would help to increase efficiency of N use and avoid environmental contamination. A total of 47 trials were conducted on research stations and private farms in four different regions of North Carolina and Virginia from 2014 to 2016 to associate soil N availability with yield response to sidedress N application. Corn grain yield was 10.6 ± 3.4 Mg ha–1 on 36 sites and silage yield was 44.6 ± 8.2 Mg ha–1 on 11 sites. There was positive association between relative yield (i.e., yield without sidedress N application divided by yield with full fertilization) and levels of both plant available N (residual inorganic N + net N mineralization during 24 d) and the flush of CO2 following rewetting of dried soil during 3 d. Economically optimum N fertilizer requirement (EONR) at sidedress declined with increasing level of plant available N and soil‐test biological activity (i.e., the flush of CO2). The scalable N factor for production at EONR declined from 20 kg N Mg–1 of grain (i.e., 1.1 lb N bu–1) with no soil biological activity to no N required with soil‐test biological activity of 600 mg CO2–C kg–1 in a 3‐d period (depth of 0–10 cm). The flush of CO2 when determined in spring at or prior to planting corn was considered an ideal soil‐test indicator of soil biological activity due to its simple, rapid, and reliable characteristics related to potential soil N mineralization and corn yield responses to applied N fertilizer.
Removal of tetracycline antibiotics from aqueous solutions using easily regenerable pumice: batch and column study
Authors: Lu Jianbo , Xu Kai , Li Wanlu , Hao Dongmei , Qiao Lingmin 
Published: May 2018

Abstract
Mineral pumice as an adsorbent was explored for tetracycline (TC) removal from water. Pumice was characterized by X-ray diffraction, X-ray fluorescence and Fourier transform infrared spectroscopy. Batch and column studies were conducted to investigate the adsorbability of pumice towards TC. Results showed that the TC adsorption amount declined as the pH increased from 3 to 9 and was strongly dependent on ionic strength. Adsorption kinetic data fitted to the pseudo-first-order, pseudo-second-order and Elovich model very well (R2 &gt; 0.9). Intraparticle diffusion was the main rate controlling step during TC adsorption. The Langmuir and Freundlich models were utilized to simulate isotherm data (10–30°C). The obtained Langmuir uptake amount (20°C) was 3.345 mg/g. Thermodynamic analyses showed that the TC uptake amount increased with the temperature rising, suggesting its endothermic nature. At pH 6 and 8, both Pb2+ and Cu2+ significantly promoted the TC removal (&gt;25%) via ion bridging action. Adsorption mechanisms mainly involved physisorption (Van der Waals & electrostatic forces) and chemisorption via the formation of inner-sphere complexes. Column tests showed that the exhausted column could be effectively regenerated using alkaline EDTA solution. Current results suggest that pumice is a promising adsorbent for TC removal from aqueous solutions.
Selected Applications for Current Polymers in Prosthetic Dentistry - State of the Art
Authors: Kawala Maciej , Smardz Joanna , Adamczyk Lukasz , Grychowska Natalia , Wieckiewicz Mieszko 
Published: May 2018

Background:
Polymers have wide applications in medicine, including dentistry, i.e.
in prosthetic dentistry.

Aim:

The following paper is aimed at demonstrating the applications of selected modern
polymers in prosthetic dentistry based on the reported literature.

Material and Methods:

The study was conducted using the PubMed, SCOPUS and CINAHL
databases in relation to documents published during 1999–2017. The following keywords were
used: polymers with prosthetic dentistry, impression materials, denture base materials, bite
registration materials, denture soft liners, occlusal splint materials and 3D printing. Original
papers and reviews which were significant from the modern clinical viewpoint and practical
validity in relation to the possibility of using polymeric materials in prosthetic dentistry were
presented.

Results:
Denture base materials were the most commonly modified polymers. Modifications
mainly concerned antimicrobial properties and reinforcement of the material structure by introducing
additional fibers. Antimicrobial modifications were also common in case of relining
materials.

Conclusion:
Polymeric materials have widely been used in prosthetic dentistry. Modifications
of their composition allow achieving new, beneficial properties that affect the quality of patients’
life. Progress in science allows for a more methodologically-advanced research on the
synthesis of new polymeric materials and incorporation of new substances into already known
polymeric materials, that will require systematization and appropriate classification.
Selection of a GPER1 Ligand via Ligand-based Virtual Screening Coupled to Molecular Dynamics Simulations and Its Anti-proliferative Effects on Breast Cancer Cells
Authors: Martínez-Muñoz Alberto , Prestegui-Martel Berenice , Méndez-Luna David , Fragoso-Vázquez Manuel J. , García-Sánchez José Rubén , Bello Martiniano , Martínez-Archundia Marlet , Chávez-Blanco Alma , Dueñas-González Alfonso , Mendoza-Lujambio Irene , Trujillo-Ferrara José , Correa-Basurto José 
Published: May 2018

Background:
Recent reports have demonstrated the role of the G Protein-Coupled Estrogen Receptor
1 (GPER1) on the proliferation of breast cancer. The coupling of GPER1 to estrogen triggers cellular signaling
pathways related to cell proliferation.

Objective:
Develop new therapeutic strategies against breast cancer.

Method:
We performed in silico studies to explore the binding mechanism of a set of G15 /G1 analogue compounds.
We included a carboxyl group instead of the acetyl group from G1 to form amides with several moieties
to increase affinity on GPER1. The designed ligands were submitted to ligand-based and structure-based virtual
screening to get insights into the binding mechanism of the best designed compound and phenol red on GPER1.

Results:
According to the in silico studies, the best molecule was named G1-PABA ((3aS,4R,9bR)-4-(6-
bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid). It was
synthesized and assayed in vitro in breast cancer (MCF-7 and MDA-MB-231) and normal (MCF-10A) cell
lines. Experimental studies showed that the target compound was able to decrease cell proliferation, IC50 values
of 15.93 µM, 52.92 µM and 32.45 µM in the MCF-7, MDA-MB-231 and MCF-10A cell lines, respectively,
after 72 h of treatment. The compound showed better IC50 values without phenol red, suggesting that phenol red
interfere with the G1-PABA action at GPER1, as observed through in silico studies, which is present in MCF-7
cells according to PCR studies and explains the cell proliferation effects.

Conclusion:
Concentration-dependent inhibition of cell proliferation occurred with G1-PABA in the assayed
cell lines and could be due to its action on GPER1.
Detection and Molecular Characterization of Vibrio Parahaemolyticus in Shrimp Samples
Authors: Asgarpoor Daryoush , Haghi Fakhri , Zeighami Habib 
Published: May 2018

Background:Food safety has emerged as an important global issue with international trade and public health implications. Bacterial pathogens asVibrio parahaemolyticusrecognized as an important cause of foodborne diseases related to the consumption of raw, undercooked or mishandled seafood worldwide.Methods:A total of 70 individual wild shrimp samples were collected from shrimp retail outlets in Zanjan, Iran and investigated for the presence of potentially pathogenic strains ofV. parahaemolyticus.The shrimp samples were immediately homogenized and cultured on TCBS agarand subjected to confirmatory biochemical tests. Polymerase Chain Reaction (PCR) was performed for detection of total and pathogenicV. parahaemolyticusby amplification ofvp–toxR,tdhandtrhgenes.Results:The conventional method indicated that 16 (22.8%) of samples were positive forV. parahaemolyticus. However, PCR verified that only 12 (17.1%) shrimp samples were positive forV. parahaemolyticus.Of the 70 shrimp samples in our study, only 2 (2.8%)tdhand 1 (1.4%)trhpositive strains were identified.Conclusion:Detection oftdhand/ ortrhpositiveV. parahaemolyticusin shrimp marketed in Zanjan, Iran shows a probable risk for public health. Therefore, the reliable molecular methods for monitoring of potentially pathogenicV. parahaemolyticusare strongly recommended for the routine seafood examination.
Lattice Boltzmann Simulation of Natural Convection in a Fractured Petroleum Reservoir Domain: Single-Phase and Multi-Phases Investigations
Authors: Kaydani Hossein , Mohebbi Ali , Forghani Amir Ahmad 
Published: May 2018

Background:Natural convection is one of the main effective production mechanisms in a fractured petroleum reservoir.Objective:This paper investigated the simulation of natural convection heat transfer in a fracture domain of petroleum reservoir.Methods:This is done by using Lattice-Boltzmann Equation (LBE) method. In this study, a D2Q9 lattice model was coupled with the passive-scalar lattice thermal model to represent density, velocity and internal energy distribution function, respectively.Results and Conclusion:The results were in excellent agreement with CFD results from the literature. The effects of Rayleigh number and Aspect-Ratio (AR) on flow pattern and temperature distribution were studied. The results indicated that natural convection rate increased with the Rayleigh number increment. The local Nusselt number (Nu) was evaluated on the hot wall and it was rising with increasing the Rayleigh number. Streamlines and temperature field were affected significantly by changing the aspect-ratio. Moreover, first of all, natural convection in Single Component Mutli-Phase (SCMP) was discussed and here and then after validation of SCMP model, the results indicated that the streamline and isotherm were affected by second phases because of the formation of two-phase flow in some of the reservoirs or production period.