bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State of Speech in HCI: Trends, Themes and Challenges
Authors: Clark Leigh , Doyle Philip , Garaialde Diego , Gilmartin Emer , Schlögl Stephan , Edlund Jens , Aylett Matthew , Cabral João , Munteanu Cosmin , Edwards Justin , R Cowan Benjamin 
Published: May 2019

AbstractSpeech interfaces are growing in popularity. Through a review of 99 research papers this work maps the trends, themes, findings and methods of empirical research on speech interfaces in the field of human–computer interaction (HCI). We find that studies are usability/theory-focused or explore wider system experiences, evaluating Wizard of Oz, prototypes or developed systems. Measuring task and interaction was common, as was using self-report questionnaires to measure concepts like usability and user attitudes. A thematic analysis of the research found that speech HCI work focuses on nine key topics: system speech production, design insight, modality comparison, experiences with interactive voice response systems, assistive technology and accessibility, user speech production, using speech technology for development, peoples’ experiences with intelligent personal assistants and how user memory affects speech interface interaction. From these insights we identify gaps and challenges in speech research, notably taking into account technological advancements, the need to develop theories of speech interface interaction, grow critical mass in this domain, increase design work and expand research from single to multiple user interaction contexts so as to reflect current use contexts. We also highlight the need to improve measure reliability, validity and consistency, in the wild deployment and reduce barriers to building fully functional speech interfaces for research.RESEARCH HIGHLIGHTSMost papers focused on usability/theory-based or wider system experience research with a focus on Wizard of Oz and developed systems Questionnaires on usability and user attitudes often used but few were reliable or validated Thematic analysis showed nine primary research topics Challenges identified in theoretical approaches and design guidelines, engaging with technological advances, multiple user and in the wild contexts, critical research mass and barriers to building speech interfaces
A systematic review of the genetic mechanisms of dolutegravir resistance
Authors: Rhee Soo-Yon , Grant Philip M , Tzou Philip L , Barrow Geoffrey , Harrigan P Richard , Ioannidis John P A , Shafer Robert W 
Published: May 2019

AbstractBackgroundCharacterizing the mutations selected by the integrase strand transfer inhibitor (INSTI) dolutegravir and their effects on susceptibility is essential for identifying viruses less likely to respond to dolutegravir therapy and for monitoring persons with virological failure (VF) on dolutegravir therapy.MethodsWe systematically reviewed dolutegravir resistance studies to identify mutations emerging under dolutegravir selection pressure, the effect of INSTI resistance mutations on in vitro dolutegravir susceptibility, and the virological efficacy of dolutegravir in antiretroviral-experienced persons.Results and conclusionsWe analysed 14 studies describing 84 in vitro passage experiments, 26 studies describing 63 persons developing VF plus INSTI resistance mutations on a dolutegravir-containing regimen, 41 studies describing dolutegravir susceptibility results, and 22 clinical trials and 16 cohort studies of dolutegravir-containing regimens. The most common INSTI resistance mutations in persons with VF on a dolutegravir-containing regimen were R263K, G118R, N155H and Q148H/R, with R263K and G118R predominating in previously INSTI-naive persons. R263K reduced dolutegravir susceptibility ∼2-fold. G118R generally reduced dolutegravir susceptibility >5-fold. The highest levels of reduced susceptibility occurred in viruses containing Q148 mutations in combination with G140 and/or E138 mutations. Dolutegravir two-drug regimens were highly effective for first-line therapy and for virologically suppressed persons provided dolutegravir’s companion drug was fully active. Dolutegravir three-drug regimens were highly effective for salvage therapy in INSTI-naive persons provided one or more of dolutegravir’s companion drugs was fully active. However, dolutegravir monotherapy in virologically suppressed persons and functional dolutegravir monotherapy in persons with active viral replication were associated with a non-trivial risk of VF plus INSTI resistance mutations.
Omadacycline as a promising new agent for the treatment of infections with Mycobacterium abscessus
Authors: Bax Hannelore I , de Vogel Corné P , Mouton Johan W , de Steenwinkel Jurriaan E M 
Published: May 2019

Abstract

Background
Despite intensive treatment regimens, the outcome of Mycobacterium abscessus infections is extremely poor and thus novel treatment regimens are needed. Although tigecycline seems to be one of the best options currently available, its long-term use is hampered by severe toxic side effects as well as the need for intravenous administration and the relatively high concentrations required for efficacy.

Objectives
To assess the in vitro activity of omadacycline against M. abscessus and compare it with the activity of tigecycline.

Methods
The concentration- and time-dependent killing capacities of omadacycline and tigecycline against M. abscessus subspecies abscessus were determined using a time–kill kinetics assay. Time–kill curves as well as concentration–effect curves were generated.

Results
Time–kill curves showed strong concentration-dependent antimicrobial activity for both omadacycline and tigecycline. Omadacycline showed inhibition of mycobacterial growth at 4 mg/L and mycobacterial killing at concentrations ≥16 mg/L. Tigecycline showed mycobacterial killing at concentrations ≥4 mg/L, achieving elimination at concentrations ≥16 mg/L. The concentration–effect curves after 7 days of exposure showed stasis, 1 log mycobacterial killing and 2 log mycobacterial killing at 3.3, 4.0 and 4.8 mg/L for omadacycline and 2.2, 2.7 and 3.4 mg/L for tigecycline, respectively.

Conclusions
The results of this in vitro study on omadacycline activity, together with its favourable (pharmacokinetic) properties, suggest that omadacycline is a potential new agent for the treatment of M. abscessus infections.
Spatial and temporal genetic diversity of the Texas kangaroo rat, Dipodomys elator (Rodentia: Heteromyidae)
Authors: Pfau Russell S , Goetze Jim R , Martin Robert E , Matocha Kenneth G , Nelson Allan D 
Published: May 2019

AbstractThe Texas kangaroo rat (Dipodomys elator) is listed as a threatened species in Texas because of its scarcity and small geographic range. We assessed patterns of genetic diversity in D. elator that could affect extinction risk or influence management decisions. Specific objectives included: 1) document levels of genetic diversity, 2) document the degree and patterns of genetic divergence among localities, and 3) compare levels of genetic diversity between different time periods at the same locality. Portions of the mitochondrial genome (mtDNA; control region, cytochrome c oxidase subunit I, and cytochrome b) were sequenced and nuclear microsatellites were examined. Low mtDNA diversity was observed, which could be explained by an historical, species-wide genetic bottleneck. In contrast, microsatellites exhibited ample variation, and analyses were conducted using data from 11 loci and four populations (designated Quanah, Iowa Park, Vernon, and Harrold). Allelic diversity and heterozygosity were similar between populations and temporal samples. Estimates of effective population size (Ne) ranged from 5 to 856, depending on method and population, with Iowa Park showing consistently lower values than Quanah. All methods addressing population structure indicated that the Iowa Park population was divergent from the others, with Vernon and Harrold showing a somewhat intermediate relationship but with a closer affiliation with Quanah than Iowa Park, despite their closer proximity to Iowa Park. This pattern did not conform to isolation by distance, thus genetic drift appears to have played a greater role than gene flow in establishing genetic structure. There was much less difference between temporal samples compared to geographic samples, indicating that genetic drift has had only minimal impacts in shifting allelic frequencies over the time periods examined (17–36 years).
Effects of human-induced disturbances and weather on herbivore movement
Authors: Leclerc Martin , Tarroux Arnaud , Fauchald Per , Stien Audun , Tveraa Torkild , St-Laurent Martin-Hugues 
Published: May 2019

Abstract
Human-caused habitat disturbances and climate change are leading threats to biodiversity. Studying the impacts of human activities on wildlife from a behavioral perspective is a relevant starting point to understand the mechanisms underlying population and species resistance and resilience to disturbances. In this study, we assessed the effects of weather (temperature and precipitation), habitat disturbances (roads and clearcuts), and natural habitat types on the space use patterns of a threatened boreal population of woodland caribou (Rangifer tarandus caribou). An extensive data set of 288,665 relocations from 50 adult females outfitted with GPS collars over 7 years in the boreal forest of Québec, Canada was used to evaluate residency time in natural and disturbed habitats for five distinct biologically defined periods. The most parsimonious linear mixed-effects model for each period showed that individuals stayed longer in more natural habitat types. During calving and summer, residency time decreased with increasing road density, whereas residency time decreased with increasing temperature during winter and spring. We found no evidence of a synergistic effect between daily weather and human disturbances on movement behavior of caribou, but consider their respective influence as additive. We also showed large individual variation in residency time, except during the calving period. Lower individual variation in residency time during calving may be explained by strong evolutionary constraints on behavior faced by females to ensure protection and survival of their offspring. Based on our results, we suggest keeping large patches of suitable and roadless habitat for caribou to favor the spacing-out antipredator strategy exhibited by females during calving. By tracking individuals over several complete annual cycles, we showed variation in the effects of daily weather and human disturbances on residency time across biological periods. Our study highlights that the inclusion of daily weather variables helps better understand space-use patterns of a threatened species.
Temporal Stability and Prognostic Biomarker Potential of the Prostate Cancer Urine miRNA Transcriptome
Authors: Jeon Jouhyun , Olkhov-Mitsel Ekaterina , Xie Honglei , Yao Cindy Q , Zhao Fang , Jahangiri Sahar , Cuizon Carmelle , Scarcello Seville , Jeyapala Renu , Watson John D , Fraser Michael , Ray Jessica , Commisso Kristina , Loblaw Andrew , Fleshner Neil E , Bristow Robert G , Downes Michelle , Vesprini Danny , Liu Stanley , Bapat Bharati , Boutros Paul C 
Published: May 2019

Abstract

Background
The development of noninvasive tests for the early detection of aggressive prostate tumors is a major unmet clinical need. miRNAs are promising noninvasive biomarkers: they play essential roles in tumorigenesis, are stable under diverse analytical conditions, and can be detected in body fluids.

Methods
We measured the longitudinal stability of 673 miRNAs by collecting serial urine samples from 10 patients with localized prostate cancer. We then measured temporally stable miRNAs in an independent training cohort (n = 99) and created a biomarker predictive of Gleason grade using machine-learning techniques. Finally, we validated this biomarker in an independent validation cohort (n = 40).

Results
We found that each individual has a specific urine miRNA fingerprint. These fingerprints are temporally stable and associated with specific biological functions. We identified seven miRNAs that were stable over time within individual patients and integrated them with machine-learning techniques to create a novel biomarker for prostate cancer that overcomes interindividual variability. Our urine biomarker robustly identified high-risk patients and achieved similar accuracy as tissue-based prognostic markers (area under the receiver operating characteristic = 0.72, 95% confidence interval = 0.69 to 0.76 in the training cohort, and area under the receiver operating characteristic curve = 0.74, 95% confidence interval = 0.55 to 0.92 in the validation cohort).

Conclusions
These data highlight the importance of quantifying intra- and intertumoral heterogeneity in biomarker development. This noninvasive biomarker may usefully supplement invasive or expensive radiologic- and tissue-based assays.
A Primer on Mixed Methods for Pediatric Researchers
Authors: Wu Yelena P , Deatrick Janet A , McQuaid Elizabeth L , Thompson Deborah 
Published: May 2019

Abstract

Objective
To provide a primer on conducting and analyzing mixed methods research studies, and to provide guidance on the write-up of mixed methods research.

Methods
A question and answer format is used to provide an overview of mixed methods research study designs, tasks and considerations related to conducting and analyzing mixed methods studies, and recommendations for the write-up of results for mixed methods studies.

Results
Individuals who conduct mixed methods research are encouraged to delineate the quantitative, qualitative, and mixed methods features of the research and how these features fit with the overall study questions. Research teams will benefit from including individuals with expertise in qualitative, quantitative, and mixed methods research. Data integration should be a central component to the analysis and write-up of mixed methods research.

Conclusions
Increasing the use of mixed methods research in the field of pediatric psychology will contribute to advances in observational studies with children and families, intervention development and evaluation, and creation of new tools and assessments that aim to optimize child and family health outcomes.
Paratexts and the Reception History of the Apocalypse
Authors: Allen Garrick V 
Published: May 2019

Abstract
Biblical scholarship usually engages with reconstructed texts without taking into account the form and material culture of the manuscripts that transmit the texts used in reconstruction. This article examines the influence of paratexts on biblical studies and reception history, using the book of Revelation as a test case, in an effort to rediscover the significance of transmission for comprehending the ways in which past reading communities engaged their scriptural traditions. The liminal features of manuscripts that are often ignored in modern editions are an integral part of the artefact that influence and shape a text’s reading. This study argues that paratexts represent an underdeveloped resource for reception history, insofar as the relationship between text and paratext is rarely taken into consideration by modern interpreters. Material culture, textual transmission, reception history, and exegesis are integrally linked processes.
Affordable, Reliable Dual-Platform Approach to Quantitating Phosphatidylserine-Exposing Platelets in Platelet Components
Authors: Noulsri Egarit , Lerdwana Surada 
Published: May 2019

Abstract

Objective
To compare the number of phosphatidylserine (PS)–exposing platelets obtained using the dual-platform approach and bead-based flow cytometry.

Methods
Platelets were enumerated using the ADVIA 2010i instrument (Siemens AG). The numbers and percentages of PS-exposing platelets in 175 platelet products were determined using a FACSCalibur flow cytometer (Becton, Dickinson and Company) and counting beads.

Results
Our results showed good correlation (r2 = 0.96; P <.001) between the PS-exposing platelets obtained using counting beads and the dual-platform approach. The results of Bland-Altman analysis showed a bias of +46,449 cells per µL and a limit of agreement (LOA) from −197,863 to 290,762 cells per µL. Also, 8 measurements (5.0%) revealed a number of PS-exposing platelets outside the LOA ranges. Further, 21 measurements (12.0%) revealed greater than 2-fold changes in the number of PS-exposing platelets.

Conclusions
The results suggest that the dual-platform approach is affordable and reliable for quantitating PS-exposing platelets as part of monitoring the quality of platelet products.
Provincial dissemination of HEARTSMAP, an emergency department psychosocial assessment and disposition decision tool for children and youth
Authors: Koopmans Erica , Black Tyler , Newton Amanda , Dhugga Gurm , Karduri Naveen , Doan Quynh 
Published: May 2019

AbstractBackgroundThis article describes the provincial dissemination of HEARTSMAP, an evidence-based emergency department (ED) psychosocial assessment and disposition decision tool for clinician use with children and youth.MethodsHEARTSMAP was disseminated in partnership with local, child and youth mental health teams, as part of a quality improvement initiative implemented in British Columbia EDs. The target audience of education sessions were clinicians working in ED settings responsible for paediatric psychosocial assessments. We used the RE-AIM framework to evaluate the reach, effectiveness, adoption, implementation, and maintenance of HEARTSMAP dissemination, analyzing data from session evaluation forms and online tool data.ResultsEducation sessions reached 475 attendees, in 52 of 95 British Columbia EDs. HEARTSMAP training was well received by clinicians with 96% describing effective content including increased comfort in conducting paediatric psychosocial assessments and confidence in disposition planning after training. Clinicians identified unclear processes and lack of local resources as the main barriers to implementation. One-third of the attendees expressed willingness to use the tool, and 27% of registered clinicians have used the tool postimplementation.ConclusionsOur approach reached and effectively trained clinicians from over half of the province’s EDs to use HEARTSMAP for emergency paediatric psychosocial assessments. For some, this provided greater comfort and confidence for these assessments and the following disposition decisions. This evaluation provides valuable insights on training clinicians to use a paediatric mental health tool within diverse ED settings and emphasized the need for ongoing support and institutional engagement to facilitate local, infrastructural, and operational processes for adoption and maintenance, postdissemination.
Multiomic Analysis of Zebrafish Models of Acute Organophosphorus Poisoning With Different Severity
Authors: Piña Benjamin , Ziv Tamar , Faria Melissa , Ben-Lulu Shani , Prats Eva , II Mark A Arick , Gómez-Canela Cristian , García-Reyero Natàlia , Admon Arie , Raldúa Demetrio 
Published: May 2019

Abstract
Organophosphorus compounds are acetylcholinesterase inhibitors used as pesticides and chemical warfare nerve agents. Acute organophosphorus poisoning (acute OPP) affects 3 million people, with 300 000 deaths annually worldwide. Severe acute OPP effects include overstimulation of cholinergic neurons, seizures, status epilepticus, and finally, brain damage. In a previous study, we developed 3 different chemical models of acute OPP in zebrafish larvae. To elucidate the complex pathophysiological pathways related to acute OPP, we used integrative omics (proteomic, transcriptomics, and metabolomics) on these 3 animal models. Our results show that these stochastic, apparently disparate morphological phenotypes can result from almost linear concentration-response variations in molecular levels. Results from the multiomics analysis strongly suggest that endoplasmic reticulum stress might play a central role in the pathophysiology of severe acute OPP, emphasizing the urgent need of further research on this molecular pathway. Endoplasmic reticulum stress could be an important therapeutic target to be included in the treatment of patients with severe acute OPP.
Effect of Promotion via Social Media on Access of Articles in an Academic Medical Journal: A Randomized Controlled Trial
Authors: Widmer R. Jay , Mandrekar Jay , Ward Angelina , Aase Lee A. , Lanier William L. , Timimi Farris K. , Gerber Thomas C. 
Published: May 2019

Purpose
To study the effect of a planned social media promotion strategy on access of online articles in an established academic medical journal.

Method
This was a single-masked, randomized controlled trial using articles published in Mayo Clinic Proceedings, a large-circulation general/internal medicine journal. Articles published during the months of October, November, and December 2015 (n = 68) were randomized to social media promotion (SoMe) using Twitter, Facebook, and LinkedIn or to no social media promotion (NoSoMe), for 30 days (beginning with the date of online article publication). Journal website visits and full-text article downloads were compared for 0–30 and 31–60 days following online publication between SoMe versus NoSoMe using a Wilcoxon rank-sum test.

Results
Website access of articles from 0 to 30 days was significantly higher in the SoMe group (n = 34) compared with the NoSoMe group (n = 34): 1,070 median downloads versus 265, P < .001. Similarly, full-text article downloads from 0–30 days were significantly higher in the SoMe group: 1,042 median downloads versus 142, P < .001. Compared with the NoSoMe articles, articles randomized to SoMe received a greater number of website visits via Twitter (90 vs 1), Facebook (526 vs 2.5), and LinkedIn (31.5 vs 0)—all P < .001.

Conclusions
Articles randomized to SoMe were more widely accessed compared with those without social media promotion. These findings show a possible role, benefit, and need for further study of a carefully planned social media promotion strategy in an academic medical journal.
Using REDCap to Facilitate Web-Based Therapeutic Intervention Research
Authors: Crane Stacey , Comer Robert Skipworth , Arenson Andrew D. , Draucker Claire 
Published: May 2019

Background
Limited guidelines to assist nurse researchers who use web-based interventions are available. Nurses must develop the supporting technology enabling participants to complete study activities and collected data while maintaining data security and participant confidentiality.

Objectives
The aim of the study was to describe how the authors used advanced Research Electronic Data Capture (REDCap) functionality to support the data management infrastructure of an interactive, web-based therapeutic intervention.

Methods
The data management infrastructure for the WISER (Writing to Improve Self-in-Relationships) intervention pilot study consisted of two components: a website for presentation of the intervention and participant account management and a REDCap project for data capture and storage. The REDCap application programming interface connected these two components using HTML links and data exchanges.

Results
We completed an initial pilot study of WISER with 14 participants using the REDCap-based infrastructure. Minimal technical difficulties were encountered.

Discussion
REDCap is cost-effective, is readily available, and, through its advanced functionality, is able to facilitate confidential, secure interactions with participants, robust data management, and seamless participant progression in web-based intervention research.