bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial
Authors: Tauschmann Martin , Allen Janet M. , Nagl Katrin , Fritsch Maria , Yong James , Metcalfe Emily , Schaeffer Dominique , Fichelle Muriel , Schierloh Ulrike , Thiele Alena G. , Abt Daniela , Kojzar Harald , Mader Julia K. , Slegtenhorst Sonja , Barber Nicole , Wilinska Malgorzata E. , Boughton Charlotte , Musolino Gianluca , Sibayan Judy , Cohen Nathan , Kollman Craig , Hofer Sabine E. , Fröhlich-Reiterer Elke , Kapellen Thomas M. , Acerini Carlo L. , de Beaufort Carine , Campbell Fiona , Rami-Merhar Birgit , Hovorka Roman 
Published: January 2019

OBJECTIVE
We aimed to assess the feasibility and safety of hybrid closed-loop insulin delivery in children with type 1 diabetes aged 1–7 years as well as evaluate the role of diluted insulin on glucose control.

RESEARCH DESIGN AND METHODS
In an open-label, multicenter, multinational, randomized crossover study, 24 children with type 1 diabetes on insulin pump therapy (median age 5 years [interquartile range 3–6] and mean ± SD HbA1c 7.4 ± 0.7% [57 ± 8 mmol/mol] and total insulin 13.2 ± 4.8 units/day) underwent two 21-day periods of unrestricted living and we compared hybrid closed-loop with diluted insulin (U20) and hybrid closed-loop with standard strength insulin (U100) in random order. During both interventions, the Cambridge model predictive control algorithm was used.

RESULTS
The proportion of time that sensor glucose was in the target range between 3.9 and 10 mmol/L (primary end point) was not different between interventions (mean ± SD 72 ± 8% vs. 70 ± 7% for closed-loop with diluted insulin vs. closed-loop with standard insulin, respectively; P = 0.16). There was no difference in mean glucose levels (8.0 ± 0.8 vs. 8.2 ± 0.6 mmol/L; P = 0.14), glucose variability (SD of sensor glucose 3.1 ± 0.5 vs. 3.2 ± 0.4 mmol/L; P = 0.16), or the proportion of time spent with sensor glucose &lt;3.9 mmol/L (4.5 ± 1.7% vs. 4.7 ± 1.4%; P = 0.47) or &lt;2.8 mmol/L (0.6 ± 0.5% vs. 0.6 ± 0.4%; P &gt; 0.99). Total daily insulin delivery did not differ (17.3 ± 5.6 vs. 18.9 ± 6.9 units/day; P = 0.07). No closed-loop–related severe hypoglycemia or ketoacidosis occurred.

CONCLUSIONS
Unrestricted home use of day-and-night closed-loop in very young children with type 1 diabetes is feasible and safe. The use of diluted insulin during closed-loop does not provide additional benefits compared with standard strength insulin.
Frailty and Risk of Fractures in Patients With Type 2 Diabetes
Authors: Li Guowei , Prior Jerilynn C. , Leslie William D. , Thabane Lehana , Papaioannou Alexandra , Josse Robert G. , Kaiser Stephanie M. , Kovacs Christopher S. , Anastassiades Tassos , Towheed Tanveer , Davison K. Shawn , Levine Mitchell , Goltzman David , Adachi Jonathan D. 
Published: January 2019

OBJECTIVE
We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures.

RESEARCH DESIGN AND METHODS
Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragility fracture; secondary outcomes included time to hip fracture and to clinical spine fracture. Frailty status was measured by a Frailty Index (FI) of deficit accumulation. The Cox model incorporating an interaction term (frailty × diabetes) was used for analyses.

RESULTS
The analysis included 3,149 (70% women) participants; 138 (60% women) had diabetes. Higher bone mineral density and FI were observed in participants with diabetes compared with control subjects. A significant relationship between the FI and the risk of incident fragility fractures was found, with a hazard ratio (HR) of 1.02 (95% CI 1.01–1.03) and 1.19 (95% CI 1.10–1.33) for per-0.01 and per-0.10 FI increase, respectively. The interaction was also statistically significant (P = 0.018). The HR for per-0.1 increase in the FI was 1.33 for participants with diabetes and 1.19 for those without diabetes if combining the estimate for the FI itself with the estimate from the interaction term. No evidence of interaction between frailty and diabetes was found for risk of hip and clinical spine fractures.

CONCLUSIONS
Participants with type 2 diabetes were significantly frailer than individuals without diabetes. Frailty increases the risk of fragility fracture and enhances the effect of diabetes on fragility fractures. Particular attention should be paid to diabetes as a risk factor for fragility fractures in those who are frail.
Maternal and Newborn Vitamin D–Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes
Authors: Tapia German , Mårild Karl , Dahl Sandra R. , Lund-Blix Nicolai A. , Viken Marte K. , Lie Benedicte A. , Njølstad Pål R. , Joner Geir , Skrivarhaug Torild , Cohen Arieh S. , Størdal Ketil , Stene Lars C. 
Published: January 2019

OBJECTIVECircumstantial evidence links 25-hydroxy vitamin D [25(OH)D], vitamin D–binding protein (DBP), vitamin D–associated genes, and type 1 diabetes (T1D), but no studies have jointly analyzed these. We aimed to investigate whether DBP levels during pregnancy or at birth were associated with offspring T1D and whether vitamin D pathway genetic variants modified associations between DBP, 25(OH)D, and T1D.RESEARCH DESIGN AND METHODSFrom a cohort of &gt;100,000 mother/child pairs, we analyzed 189 pairs where the child later developed T1D and 576 random control pairs. We measured 25(OH)D using liquid chromatography–tandem mass spectrometry, and DBP using polyclonal radioimmunoassay, in cord blood and maternal plasma samples collected at delivery and midpregnancy. We genotyped mother and child for variants in or near genes involved in vitamin D metabolism (GC, DHCR7, CYP2R1, CYP24A1, CYP27B1, and VDR). Logistic regression was used to estimate odds ratios (ORs) adjusted for potential confounders.RESULTSHigher maternal DBP levels at delivery, but not in other samples, were associated with lower offspring T1D risk (OR 0.86 [95% CI 0.74–0.98] per μmol/L increase). Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77–0.98] per 10 nmol/L increase) in children carrying the VDR rs11568820 G/G genotype (Pinteraction = 0.01 between 25(OH)D level and rs11568820). We did not detect other gene-environment interactions.CONCLUSIONSHigher maternal DBP level at delivery may decrease offspring T1D risk. Increased 25(OH)D levels at birth may decrease T1D risk, depending on VDR genotype. These findings should be replicated in other studies. Future studies of vitamin D and T1D should include VDR genotype and DBP levels.
Mortero geopolimérico para uso potencial como recubrimiento en concreto
Authors: Oviedo-Sánchez Katherine , Mejía de Gutiérrez Ruby 
Published: January 2019

Se sintetizaron dos morteros geopoliméricos basados en Metacaolín y residuo de ladrillo, modificados con adiciones orgánicas e inorgánicas para ser utilizados como potenciales recubrimientos sobre concretos. Se evaluaron sus propiedades en estado fresco (fluidez, tiempo de fraguado) y en estado endurecido (resistencia a la compresión y tracción, absorción, porosidad y conductividad térmica). Los resultados muestran la viabilidad de producir morteros Clase R1 y R2 en concordancia con la Norma EN 1504-3 en cuanto a las propiedades mecánicas y se evidencia que los sistemas geopoliméricos producidos presentan menor conductividad térmica comparada a los morteros basados en OPC sugiriendo comportamiento tipo aislante.
CD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy
Authors: Gojak Refet , Hadžiosmanović Vesna , Baljić Rusmir , Zečević Lamija , Ćorić Jozo , Mijailović Željko 
Published: January 2019

SummaryBackgroundHIV infection is characterized by progressive depletion of CD4+T cells due to their reduced synthesis and increased destruction followed by marked activation and expansion of CD8+T lymphocytes. CD4/CD8 ratio was traditionally described as a marker of immune system ageing in the general population, but it increasingly appears as a marker of different outcomes in the HIV-infected population. The main objective of this study is to examine the power of CD4/CD8 ratio in predicting the occurrence of metabolic syndrome (MetS) in HIV-positive patients receiving cART therapy.Methods80 HIV/AIDS subjects were included in a retrospective case-control study. Flow cytometry was used to determine the percentage of CD4+and CD8+cells in peripheral blood of these patients. The values of biochemical parameters (triglycerides, HDL, blood sugar, blood counts), immunological parameters (CD4/CD8, PCR), anthropometric measurements and type of cART therapy were evaluated in this study.ResultsAfter six months of cART therapy 19 (23.8%) subjects had all the elements necessary for making the diagnosis of MetS. Using multivariate analysis CD4/CD8 ratio was statistically significant (p < 0.05) and had the largest effect on development of MetS (Wald = 9.01; OR = 0.45), followed by cART (Wald = 7.87; OR = 0.10) and triglycerides (Wald = 5.27; OR = 1.7). On the other hand, body weight and waist circumference showed no statistically significant effect on the development of MetS after six months of cART, p > 0.05.ConclusionsCD4/CD8 ratio proved to be a significant marker for prediction of metabolic syndrome in HIV/AIDS patients.
The importance of RET-He in the diagnosis of iron deficiency and iron deficiency anemia and the evaluation of response to oral iron therapy
Authors: Uçar Mehmet Ali , Falay Mesude , Dağdas Simten , Ceran Funda , Urlu Selin Merih , Özet Gülsüm 
Published: January 2019

SummaryBackgroundThe purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RET-He) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient’s response to oral iron treatment.MethodsThe research population consisted of 217 participants in total: 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of < 130.0 g/L was defined as indicating anemia for men, while an Hb value of < 120.0 g/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily.ResultsThe RET-He was significantly lower in the IDA group, compared to other groups (IDA: 21.0 ± 4.1, ID: 26.0 ± 4.9, non-ID anemia: 32.1 ± 6.8, control: 36.6 ± 7.0; < 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group.ConclusionsThe results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.
Representaciones sociales de las prácticas científicas en los textos escolares de ciencias naturales utilizados en escuelas chilenas sostenidas con fondos públicos
Authors: Venegas Espinoza Jennifer Andrea 
Published: January 2019

La investigación pretendió explorar las representaciones sociales que se realizan del quehacer científico en los textos del estudiante para la asignatura de ciencias naturales, utilizados en enseñanza básica en escuelas sostenidas con fondos públicos de Chile, por medio de los conceptos de Ciencia en acción y Ciencia elaborada desarrollados por B. Latour. Los textos analizados corresponden a los entregados y distribuidos de manera gratuita por el Ministerio de Educación a estudiantes de primaria. Se ha podido evidenciar que las prácticas presentadas varían por curso y por unidad; éstas tienden a reproducir representaciones asociadas a una ciencia elaborada, ya que se presentan prácticas propias de una ciencia absoluta, con saberes imposibles de ser modificados y muchas veces carecen de contexto y de historia. Los estudiantes deben corroborar saberes previamente establecidos, por lo tanto, se transmite que la ciencia es meramente comprobatoria y no explicativa.Recibido: 07 de mayo de 2018Aceptado: 15 de diciembre de 2018
Procrastinación y estrés. Análisis de su relación en alumnos de educación media superior
Authors: Barraza Macías Arturo , Barraza Nevárez Salvador 
Published: January 2019

En la presente investigación se tiene como objetivo central determinar la relación que existe entre la procrastinación académica y el estrés académico en estudiantes de educación media superior. Para el logro de dicho objetivo se aplicaron la Escala de Procrastinación Académica y el Inventario SISCO para el estudio del estrés académico a una muestra de 300 alumnos de una institución de educación media superior. Sus resultados indican diversos niveles de relación y no relación entre ambas variables, tomando como base sus dimensiones constitutivas o su valor general como variables. Se concluye la necesidad de revisar el concepto de procrastinación y su relación con la autorregulación académica.Recibido: 20 de agosto de 2018Aceptado: 22 de diciembre de 2018
Induksi PLB Anggrek Vanda sumatrana Schltr. Liar Pada Media MS dengan Penambahan BAP dan NAA serta Ploidisasi dengan Kolkisin
Authors: Aini Hanifah - , Mansyurdin Mansyurdin - , Suwirmen Suwirmen - 
Published: January 2019

The study about PLB induction of wild Vanda sumatrana Schltr. on MS media suplement with BAP and NAA and ploidisation by colchicine treatment was conducted from December 2014 until November 2015 at the Laboratory of Genetics and Cell Biology and Laboratory of Plant Physiology and Tissue Culture, Biology department, Faculty of Mathematic and Natural Science, Andalas University, Padang. The study aimed to 1) knowing the best concentration of 6-Benzyl amino purin (BAP) and α-Naphtalene acetic acid (NAA) for Protocorm Like Bodies (PLB) induction from shoot tip of V. sumatrana, 2) knowing the PLB response of V. sumatrana to concentrations and soak period of colchicine and 3) find the effective concentrations and soak period of colchicine to induce tetraploid on PLB of V. sumatrana. Shoot tips from in-vitro cultured of V. sumatrana were subcultured on Murashinge and Skoog (MS) medium supplement with 3 mg/l BAP + 0,5 mg/l NAA, 3 mg/l BAP and 1,5 mg/l BAP. PLB of diploid V. sumatrana from the best treatment were soaked in 0.05% and 0.1% colchicine for 24 and 48 hours respectively in MS liquid medium, as control were set PLB without colchicine treatment. The results showed that MS medium supplemented with 1.5 mg/l BAP was the best formula to induce PLB. The highest percentage of survival rate of PLB and percentage of survived PLB regenerated shoot was obtained from 0.05% colchicine with 24 hours soak period treatment. The effective treatment to induce tetraploid on PLB of V. sumatrana Schltr. was obtained from 0.05% colchicine solution for 24 hours soak period.
Komunitas Makrozoobentos sebagai Indikator Biologis Kualitas Air Sungai Masang Kecil yang Menerima Limbah Cair Industri Minyak Kelapa Sawit di Kinali Pasaman Barat
Authors: Izmiarti Izmiarti , Savitri Vivi 
Published: January 2019

The industrial liquid waste of crude palm oil contains organic material that can lead to degradation of water quality and ultimately affect the macrozoobenthos communities living on the river bed. The Masang Kecil River in Kinali Pasaman Barat receives the liquid waste of the palm oil industry. The research aimed to find out the composition and structure of macrozoobentos community in Masang Kecil River and determine the water quality of river based on macrozoobenthic community structure was done in June 2017. The research was conducted by survey method with purposive sampling technique. Samples were collected on 3 stations: Station I before entering the liquid waste of palm oil industry, Station II after entering the waste, Station III is located after Station II which has been entered by Anak Aia stream. In each station collected three samples of macrozoobentos with a surber net size of 30x30 cm2. The results showed that macrozoobenthos community found 43 species consist of 33 species of Insecta, Oligochaeta 4 species, Gastropoda 3 species, Hirudinae 2 species, Arachnida and Turbellaria one species respectively. The largest number of individuals was shown by Insecta (71.89%) followed by Hirudinea (25.1%) and the other class was not more than 3%. The highest density is found at station III and the lowest at station I. The dominant species on station I were Stenelmis sp. and Psephenoides sp., stations II and III were Erphobdella sp. and Hydropsyche elisoma. The diversity index ranges from 1.49 to 3.01. The index of equitability ranges from 0.47 to 0.89, the dominant index ranges from 0.06 to 0.43. The similarity of communities between station ranged from 38.46 - 55.0%. Based on the index of diversity, water quality in Station I was classified as not polluted, Station II and III classified as moderate.
Karakteristik Dan Penyebab Kecelakaan Lalu Lintas Di Indonesia Tahun 2012
Authors: Herawati Herawati 
Published: January 2019

Penyebab kematian ketiga tertinggi di Indonesia disebabkan karena tingginya angka kecelakaan lalu lintas. Perlu langkah prefentif yang cepat karena jumlah korban yang cukup besar akan memberikan dampak ekonomi (kerugian material) dan sosial yang tidak sedikit. Upaya-upaya pengurangan kecelakaan tersebut dapat dilakukan apabila diketahui karakteristik dan penyebabnya. Untuk itu, kajian ini dilakukan untuk mengidentifikasi karakteristik kecelakaan dan penyebabnya. Data kecelakaan yang akan digunakan dalam analisis ini merupakan data kecelakaan di Indonesia pada tahun 2012. Analisis yang digunakan merupakan analisis kuantitatif deskriptif dengan menggunakan 5W dan 1H.Hasil analisis data kecelakaan di Indonesia pada tahun 2012 dibagi menjadi 6 kelompok. Kelompok “what” adalah tipe kendaraan yang paling banyak terlibat dalam kecelakaan adalah sepeda motor (65%). Kelompok “who” adalah karakteristik pelaku dan korban kecelakaan yang didominasi oleh usia produktif (71%), berjenis kelamin laki-laki(>53%), berprofesi sebagai karyawan swasta (>54%) dan tingkat pendidikan yang masih SLTA (>51%). Kategori “why” adalah faktor penyebab kecelakaan terdiri dari faktor manusia (kurang tertib), faktor kendaraan (rem blong sebanyak 27%), jalan (kurangnya fasilitas keselamatan dijalan sebanyak 50%) dan lingkungan (hujan 51%). Kategori “when” adalah waktu kejadian kecelakaan yang paling banyak terjadi 06.00-18.00 sebanyak 62%. Kategori “where” yaitu lokasi rawan kecelakaan terjadi pada daerah yang memiliki kecepatan ijin yang tinggi dan hambatan samping yang besar seperti jalan arteri 38%, jalan kabupaten (38%) dan kawasan permukiman (77%). Terakhir adalah kategori how. Tipe pergerakan kendaraan yang paling banyak menyebabkan kecelakaan yaitu tabrakan depan-depan (24%) dan depan-samping (22%). Kata kunci : karakteristik kecelakaan, penyebab, kendaraan bermotor
PENDEKATAN PRAGMATIK NILAI PENDIDIKAN KARAKTER NOVEL DAN RELEVANSINYA SEBAGAI MATERI AJAR SASTRA
Authors: Azhari Tiara Yuniar 
Published: January 2019

AbstractThis research is motivated by the collapse of the value of character education that is being planted by students, especially high school students. The teenage age instability, students are easily influenced by the social environment; to avoid this they must get used to love reading, namely reading novels. Many life values can be taken from this novel, especially in the value of character education so it can motivate readers about the world of education that can be used as a model in behave. This research is a qualitative descriptive study. The object of this research is the novel Sekolah Pohon by Eko Kusumawijaya. Data were analyzed using qualitative descriptive analysis techniques with assessment and description of the data that had been obtained. The method of data collection is done by conducting literature studies. The result of this study are: (1) the value of character education in the novel Sekolah Pohon by Eko Kusumawijaya uses a pragmatic approach which includes religious values, honesty, discipline, hard work, creative, independent, curiosity, democratic, appreciate achievement, friendly/communicative, love of peace, likes to read, environmental care, social care, and responsibility; and (2) the novel Sekolah Pohon by Eko Kusumawijaya has relevance as a literary teaching material in high school in accordance with the syllabus and lesson plans.Keywords: novel, value of character education, pragmatic approach, teaching material
PENINGKATAN KEMAMPUAN MENULIS KREATIF PUISI DENGAN PENDEKATAN WHOLE LANGUANGE DAN MEDIA TIGA DIMENSI
Authors: Dameyanti Dameyanti 
Published: January 2019

AbstractThe purpose of this research is to describe the implementation and evaluation of active learning The purpose of this study is to implement and describe the planning of the implementation and outcomes of creative writing poetry with the whole language approach and three-dimensional media class VII SMP 6 Nanga Pinoh. This research method is descriptive qualitative research design class action (PTK). This study was conducted in three cycles, each cycle conducted 2 meetings. The results of this study include: planning in cycle 1 including good enough category reached 77.6% in the second cycle increased by 20% to reach 97.6% are very good, while the third cycle increased by 2.4% to reach 100% with very good category. While the results of the implementation of the first cycle of 71.61% are good enough. In tshe second cycle increased by 18.07% to 89.68% very good category. In the third cycle increased by 9.03% with very good categories and almost close to perfect. For the results of creative writing poetry with the whole language approach and three dimensional media was successful, with the result of the average value in the first cycle of 65.33 with 29.62% completeness study (8), the second cycle of the average value increased to 78.81 and mastery learning rose by 48.16% to 77.78%, and the third cycle the average value becomes 86.37 with an increase mastery learning which is 14.81% to 92.59% (25 people), including the category of very good (SB). Keywords : Ability, Creative Writing Poetry, Whole Language Approach, Three-Dimensional Media
PENERAPAN MODEL PEMBELAJARAN PETA PIKIRAN UNTUK MENINGKATKAN KETERAMPILAN MENULIS CERPEN SISWA SMK
Authors: Bunga Jimiana 
Published: January 2019

AbstractThe backrond of this research is about the low of study result. The focus of this research is made short story text with mind map model. This model ia a way how to increase the students ability in short story in a good text. The method used in this research is qualitative-descripstive method. The subject of this research is
Office Administration in SMK Negeri 3 Pontianak. The object research is the mind map model. The research instrument used is the test of study result in the form of short story text created by students which has been the validaty and reliabelity of test and also the observation sheet for observatioan the learning activity of the students and researcher. This can be seen from the data obtained in the first cycle planning of 91%, II 95% silkus, and the third cycle remains 95%. Implementation in the first cycle of 88%, the second cycle of 94% and the third cycle of 97%. Average learning outcomes also experienced an increase in the first cycle of 80,42, the second cycle of 82,52, and the third cycle of 94,78. Responsive aspects of cycle I to very good 3%, 50% cycle II, cycle III 50%. Keywords: short story text and mind map model