bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Outcomes of Patients with Metastatic Non-Small Cell Lung Cancer Treated with Programmed Cell Death Protein 1 Inhibitors in the Year Following U.S. Regulatory Approval
Authors: Khozin Sean , Carson Kenneth R. , Zhi Jizu , Tucker Melisa , Lee Shannon E. , Light David E. , Curtis Melissa D. , Bralic Marta , Kaganman Irene , Gossai Anala , Hofmeister Philip , Torres Aracelis Z. , Miksad Rebecca A. , Blumenthal Gideon Michael , Pazdur Richard , Abernethy Amy P. 
Published: December 2018

Abstract

Background
Evidence from cancer clinical trials has strong internal validity but can be difficult to generalize to real-world patient populations. Here we analyzed real-world outcomes of patients with metastatic non-small cell lung cancer (mNSCLC) treated with programmed cell death protein 1 (PD-1) inhibitors in the first year following U.S. regulatory approval.

Materials and Methods
This retrospective study leveraged electronic health record (EHR) data collected during routine patient care in community cancer care clinics. The cohort included patients with mNSCLC who had received nivolumab or pembrolizumab for metastatic disease (n = 1,344) with &gt;1 EHR-documented visit from January 1, 2011, to March 31, 2016. Patients with a &gt; 90-day gap between advanced disease diagnosis and first EHR structured data entry were excluded.

Results
Estimated median overall survival (OS) was 8.0 months (95% confidence interval 7.4–9.0 months). Estimated median OS was 4.7 months (3.4–6.6) for patients with anaplastic lymphoma kinase rearrangement- and epidermal growth factor receptor mutation-positive tumors, and 8.6 months (7.7–10.6) for patients without such mutations. Age at PD-1 inhibitor initiation or line of therapy did not impact OS.

Conclusion
This analysis suggests OS in real-world patients may be shorter than in conventional clinical trial patient cohorts, potentially due to narrow trial eligibility criteria. The lack of difference in OS by line of therapy or age at immunotherapy initiation suggests sustained benefit of PD-1 inhibitors in multitreated patients with mNSCLC and that age is not a predictor of outcome. Further studies are underway in patients with comorbidities, organ dysfunction, and multiple prior therapies.
Genotoxic evaluation of polystyrene microplastic
Authors: BERBER Ahmet Ali 
Published: December 2018

Pollution of the aquatic environment by microplastic
could be having a massive impact on marine life. As far as the dimensions of
the microplastics decrease, the negative effects are also increasing. In this study, the effects of 1 µm diameter
polystyrene microplastics (PSMs) on Daphnia
magna and Neocaridina davidi were
investigated. The acute toxicity test was conducted on Daphnia magna. According to the test LC50 value was
calculated as 808.97 μg/mL. According to genotoxic evaluation on Neocaridina davidi with single cell gel
electrophoresis (Comet), tail length, tail intensity and tail moment were
increased by PSMs compared to the control.
The influence of canola oil biodiesel on performance, combustion characteristics and exhaust emissions of a small diesel engine
Authors: ŞEN Mehmet 
Published: December 2018

In this work, the influence of canola oil
biodiesel addition to eurodiesel was evaluated on combustion, performance characteristics
and exhaust emissions of a single cylinder diesel engine. In the experiments,
fuel mixtures obtained by adding 10%, 20% and 50% canola oil biodiesel (named COB10,
COB20 and COB50 respectively) to eurodiesel fuel (COB0) were used.The test engine
was loaded at full load with electrical dynamometer and data was recorded
between 1500 rpm and 3000 rpm at 500 rpm intervals. The result show that
addition of biodiesel to eurodiesel reduced
cylinder pressure, engine torque and BTE while increased BSFC. Ignition delay
decreased slightly with the addition of biodiesel. NOx emission and smoke density was
decreased as the biodiesel content increase in the fuel blends.
Researching Usage of Globe Culture Dimensions In Organizational Management By Using Dematel Method
Authors: ALKAN Atakan , CANBAY Kamile , AKMAN Gülşen , ALADAĞ Zerrin 
Published: December 2018

Management of organizational
culture has been increasing its importance in competitive business world
rapidly. This paper is an output of the research about impact of GLOBE culture
dimensions which is one of the most comprehensive research result so far on
organizational culture. DEMATEL methodology determines criteria importance and
interaction of criteria. In this paper; GLOBE culture dimensions, which emerged
as the product of the most comprehensive work, are linked to the strategy of
organizational culture management. Evaluations of 10 middle and high level
managers from different sectors were collected in this experimental research.
Research was performed on the basis of these evalutions, and data is analyzed
in a three-phase by using the DEMATEL method. In each analysis, thresholds have
been changed and outputs was examined to determine which organizational management strategy could be
used with GLOBE culture dimensions.
Review of first clinical experiences with a 1.5 Tesla ceiling-mounted moveable intraoperative MRI system in Europe
Authors: Feigl Guenther C. , Heckl Stefan , Kullmann Marcel , Filip Zoltan , Decker Karlheinz , Klein Jan , Ernemann Ulrike , Tatagiba Marcos , Velnar Tomaz , Ritz Rainer 
Published: December 2018

High-field intraoperative MRI (iMRI) systems provide excellent imaging quality and are used for resection control and update of image guidance systems in a number of centers. A ceiling-mounted intraoperative MRI system has several advantages compared to a conventional iMRI system. In this article, we report on first clinical experience with using such a state-of-the-art, the 1.5T iMRI system, in Europe. A total of 50 consecutive patients with intracranial tumors and vascular lesions were operated in the iMRI unit. We analyzed the patients’ data, surgery preparation times, intraoperative scans, surgical time, and radicality of tumor removal.
Patients’ mean age was 46 years (range 8 to 77 years) and the median surgical procedure time was 5 hours (range 1 to 11 hours). The lesions included 6 low-grade gliomas, 8 grade III astrocytomas, 10 glioblastomas, 7 metastases, 7 pituitary adenomas, 2 cavernomas, 2 lymphomas, 1 cortical dysplasia, 3 aneurysms, 1 arterio-venous malformation and 1 extracranial-intracranial bypass, 1 clival chordoma, and 1 Chiari malformation. In the surgical treatment of tumor lesions, intraoperative imaging depicted tumor remnant in 29.7% of the cases, which led to a change in the intraoperative strategy.
The mobile 1.5T iMRI system proved to be safe and allowed an optimal workflow in the iMRI unit. Due to the fact that the MRI scanner is moved into the operating room only for imaging, the working environment is comparable to a regular operating room.
Exploring Collaborative Learning with a Focus on Group Activities in EFL Classrooms
Authors: KOÇ Ebru 
Published: December 2018

This study aims to
investigate the views of English-language teachers and their students with
respect to collaborative learning (CL) and more specifically, with respect to
group activities. The study included 25 Turkish English-language teachers and
their 486 EFL (English as a Foreign Language) students. The data were collected
from separate questionnaires completed by the students and the teachers.
Additionally, four teachers and 10 students were interviewed. The percentage of
responses for each option of each question was calculated for each item on both
questionnaires.

The recorded interviews were analysed through
content analysis. The results indicate that most of the students favor group
activities in the classroom, whereas the teachers exhibit far less enthusiasm
for group activities because of difficulties associated with classroom
management and excessive noise levels generated during group activities. It is
suggested that teachers receive training in CL so that they can effectively
implement the technique in the classroom and teach their students how to
effectively use their interactional skills during CL activities.
Relato de experiência: oficina pedagógica como objeto de aprendizagem na formação inicial do pedagogo no Consórcio CEDERJ
Authors: Martínez Silvia Alicia , Araújo Fabrícia Vieira de , Souza Suelen Ribeiro de , Vargas Evandro , Pinho Leandro Garcia 
Published: December 2018

RESUMO: O presente trabalho objetiva abordar, analisar e discutir uma significativa experiência de ensino e aprendizagem adquirida em uma oficina pedagógica, no âmbito do Curso de Pedagogia da Universidade Estadual do Norte Fluminense (UENF), no bojo do Centro de Educação a Distância do Estado do Rio de Janeiro (CEDERJ). Tal atividade foi concretizada por professores, tutores e alunos das disciplinas História na Educação 1 e História na Educação 2 do curso supracitado. A partir das referências de diferentes pesquisadores do campo do Ensino de História e da Educação, discorremos em um momento inicial acerca da organização e estruturação da Oficina, para posteriormente tratarmos da concretização da atividade em si pelos estudantes. A Oficina muito contribuiu para a reflexão acerca das práticas pedagógicas e para uma maior aproximação entre docentes, tutores e estudantes, bem como oportunizou pensamentos acerca das diferentes tecnologias e outros materiais que podem ser empregadas no ensino de História. PALAVRAS-CHAVE: oficina pedagógica; ensino de História; educação a distância; curso de Pedagogia. ABSTRACT: The present work aims at addressing, analyzing and discussing a significant experience of teaching and learning acquired in a pedagogical workshop, within the course of pedagogy of the State University of the North Fluminense (UENF), in the Centre of Distance Education of the State of Rio de Janeiro (CEDERJ). Such activity was accomplished by teachers, tutors and students of the disciplines History in Education 1 and History in Education 2 of the aforementioned course. From the references of different researchers of the field of History Teaching and Education, we have come at an initial moment about the organization and structuring of the workshop, to subsequently embrace the realization of the activity itself by the students. The workshop contributed greatly to reflect on pedagogical practices and for a closer approximation among teachers, tutors and students, as well as it allowed to think the different technologies and other materials that can be employed in the History teaching. KEYWORDS: Pedagogical workshop; History teaching; distance education; Pedagogy course.
Narrativa seriada e comunicação: meios, modos e tempos
Authors: Mattos Cristine Fickelscherer 
Published: December 2018

RESUMO: O trabalho observa as características comunicativas da narrativa seriada do ponto de vista dos estudos contemporâneos de narratologia, em diversos tempos, modos e meios. Emprega o conceito de narrativa transmidiática para examinar a diversificada dinâmica de produção e recepção do gênero serial de forma contrastiva e diacrônica, e pondera acerca de seus efeitos sobre os seus elementos narrativos. Observa como inovações tecnológicas suscitam novos modos de narrativa seriada, que acionam novas referencialidades, através da complexa triangulação que envolve produção, recepção e meio de transmissão. Estuda ainda como contextos midiáticos específicos associam-se a disposições produtivas e receptivas que trabalham as heranças da narrativa seriada para simultaneamente alterá-las e reafirmá-las.
PALAVRAS-CHAVE: narratologia transmidiática; narrativa seriada;série televisiva.

ABSTRACT: The work observes the communicative characteristics of the serial narrative from the point of view of contemporary studies of narratology, at different ages, modes and media. Inside a transmedial narratology, it examines its diversified dynamics of production and reception in a contrastive and diachronic way and ponders about its effects on the narrative elements. It observes how technological innovations give rise to new modes of serial narrative that trigger new referentialities through the complex triangulation that involves production, reception, and mediation. It also studies how specific media contexts associate themselves with productive and receptive dispositions that work the heritages of the serial narrative to change and simultaneously reaffirm them.
KEYWORDS: transmedialnarratology; serial narrative; TV show.
Gui Builder Mod: uma ferramenta para criação de aplicações gráficas móveis em Tcl/Tk
Authors: Rocha Lucio Agostinho 
Published: December 2018

RESUMO: O processo de desenvolvimento de interfaces gráficas para o usuário (GUI) de aplicações móveis consome muito tempo durante o ciclo de desenvolvimento. Este artigo tem o objetivo de propor uma nova ferramenta para rápido desenvolvimento de apps Tcl/Tk para a plataforma Android. O método utilizado foi criar um software em Tcl/Tk para a geração de aplicativos para dispositivos móveis. Essa solução é factível para simplificar o complexo processo de desenvolvimento de novos apps e reduzir o esforço inerente de criar aplicações leves que consomem menos recursos de processamento e memória. Como resultado, foi realizado um experimento que mostra o processo de desenvolvimento de uma nova GUI para aplicações robóticas construída com a ferramenta proposta. A principal conclusão é que a ferramenta simplifica a criação de GUIs e gera aplicativos que consumem menos recursos durante sua execução.
PALAVRAS-CHAVE: Android; Tcl/Tk; Interface gráfica do usuário.

ABSTRACT: The development process of graphical interfaces for users (GUI) of mobile aplications consumes a lot of time during the development cicle. This article aims at proposing a new toolkit for fast development of Tcl/Tk apps for the Android platform. The method used was building a Tcl/Tk software to generate aplications for mobile devices. This solution is feasible to simplify the complex development process of new apps, and reducing the inherent effort of create tiny aplications that consumes less resources of processing and memory. As a result was done an experiment that shows the development process of a new GUI for robotic applications built with the proposed toolkit. The main conclusion is that the toolkit simplifies the building of GUIs, and generates aplications that consume less resources during its running.
KEYWORDS: Android; Tcl/Tk; graphical user interface.
Diagnostic vs therapeutic splenectomy: the trend in tertiary center
Authors: Nadarajan Abinaya R. , Roopavathana S. Beulah , Chase Suchita , Nayak Sukria 
Published: December 2018

Background: The recent trend being towards spleen preservation, it is necessary to critically analyse the indications for splenectomy and assess if the desired preoperative outcomes are achieved by splenectomy.Methods: This was a retrospective study and patients who underwent elective or emergency splenectomy for various indications in the surgical unit from September 2011 to July 2016 were included. The data was collected from patients records and hospital electronic database.Results: From September 2011 to July 2016, totally 68 patients underwent splenectomy. The indications for therapeutic intervention were splenic abscess (2), splenic cyst (4), trauma (8), ITP (20) and anemia (12). The indications for diagnostic splenectomy were pyrexia of unknown origin in 7 patients and splenomegaly with anemia or pancytopenia in 15 patients. The objective of the operation was achieved in 43 patients (63%). The success rate for each indication: diagnosis (12 of 22 patients, 55%), thrombocytopenia (12 of 20 patients, 60%), anemia (5 of 12 patients, 42%) and as a primary treatment (12 of 14 patients, 86%). Postoperative morbidity within 30days of surgery was seen in 9 patients (13%) and 2 patients (3%) died within 30days of surgery.Conclusions: The indication for splenectomy should be individualized after exploring all other treatment options and based on outcome.
ارتباط وضعیت اقتصادی-اجتماعی خانوار با چاقی عمومی و چاقی شکمی در کودکان دبستانی شهر فرخ شهر در سال 1388
Authors: بصیرت ریحانه , هاشمی پریسا حاجی , مقدم اسماء سالاری , شفیعی فاطمه , زاده احمد اسماعیل , لاریجانی باقر , ابرقویی امین صالحی 
Published: December 2018

مقدمه: با توجه به محدودیت اطلاعات در رابطه با وضعیت اقتصادی- اجتماعی و چاقی عمومی/ شکمی در کودکان، هدف ما بررسی ارتباط بین وضعیت اقتصادی-اجتماعی خانوار و چاقی کودکان است.
روش بررسی: این مطالعه مقطعی در فرخ‌شهر بر روی دانش آموزان 12-6 ساله در سال 1388 انجام شد. به وسیله نمونه‌گیری تصادفی خوشه­ای چند مرحله­ای 380 نفر از نواحی مختلف انتخاب شدند. با استفاده از پرسش نامه، وضعیت اقتصادی- اجتماعی تعریف شد و شرکت‌کنندگان به صورت سهک دسته‌بندی شدند. اضافه وزن/چاقی و هم چنین چاقی شکمی بر مبنای حدود مرزی ملی مختص سن و جنس تعریف شدند. مقایسه متغیرهای پیوسته و دسته­بندی شده به ترتیب بوسیله Independent samples’ t-test و آزمون مجذور کای انجام شد. برای ارزیابی وضعیت اقتصادی- اجتماعی در ارتباط با چاقی عمومی و شکمی در مدل­های تعدیل شده تک/چند متغیره از آنالیز رگرسیون لجستیک استفاده شد. تمام آنالیزهای آماری با استفاده از نرم افزار SPSS15 انجام شد.value P کمتر از 05/0 از نظر آماری معنی­دار در نظر گرفته شد.
نتایج: با مقایسه افراد بالاترین سهک با پایین‌ترین سهک، تفاوت معنی­داری در میانگین دورکمر دیده نشد، ولی افراد سهک متوسط بعد از کنترل مخدوشگرهای بالقوه، میانگین BMI بالاتری داشتند (27/0±19/16در مقابل 27/0±27/15 کیلوگرم بر متر مربع، 002/0=P). شانس اضافه وزن/ چاقی در افراد بالاترین سهک نسبت به پایین‌ترین سهک بیشتر بود (4=OR، 59/10–53/1=CI‌ 95%، 004/0=Ptrend). ارتباط معنی­داری بین وضعیت اقتصادی-اجتماعی و چاقی شکمی قبل و بعد از کنترل مخدوشگرهای بالقوه دیده نشد.
نتیجه‌گیری: کودکان بالاترین سهک شانس بیشتری برای اضافه وزن/چاقی داشتند.
فراتحلیل اثربخشی درمان¬های مبتنی بر ذهن آگاهی بر افسردگی و اضطراب (پژوهش های منتشر شده در ایران بین سال¬های ۱۳۸۰ تا ۱۳۹۵)
Authors: زهرا سادات حسینی , مجید یوسفی افراشته , مروتی ذکراله 
Published: December 2018

مقدمه: افسردگی و اضطراب از شایع­ترین اختلال­های روان شناختی محسوب می­شوند، بنابراین لازم است تا در جهت ارتقای روش­های درمانی میزان اثربخشی درمان­های گوناگون مورد مطالعه قرار بگیرد. از این رو پژوهش حاضر، با هدف بررسی فراتحلیل میزان اثربخشی درمان­های مبتنی بر ذهن آگاهی بر افسردگی و اضطراب بر اساس تحقیقات صورت گرفته در ایران بین سال­های ۱۳۸۰ تا ۱۳۹۵ صورت گرفته است.
روش بررسی: در این پژوهش از روش فراتحلیل استفاده گردید و پس از بررسی تعداد زیادی از مقالات و پژوهش­های صورت گرفته، با استفاده از پایگاه های اطلاعاتی مثل SID، Magiran، Irandoc، Civilica، Ricest، Noormags و Ensani.ir ۳۸ مطالعه انتخاب گردید. هم چنین در جهت رعایت ملاک­های ورود و استخراج اطلاعات مربوط به هر مطالعه از چک لیست استفاده شد و در نهایت ۵۹ اندازه اثر گزارش گردید. تحلیل­های آماری مربوطه با استفاده از نرم افزار فراتحلیل جامع (CMA-2) صورت گرفته است.
نتایج: یافته­های حاصل نشان داد که درمان­های مبتنی بر ذهن آگاهی به­طور معنی­دار در سطح خطای کمتر از ۰۵/۰ بر افسردگی و اضطراب موثر بوده است و اندازه اثر ترکیبی حاصل برای افسردگی و اضطراب بر حسب مقیاس هم بستگی به ترتیب ۵۷۴/۰ و ۶۰۷/۰، بر حسب مقیاس تفاوت میانگین­های استاندارد ۴۲۷/۱ و ۵۵۴/۱ و بر حسب مشخصه g هجز نیز ۳۸۹/۱ و ۵۱۱/۱ گزارش شد. هم چنین بررسی متغیر جنسیت به عنوان متغیر تعدیل کننده نیز عدم معنی­داری تفاوت مشاهده شده را نشان داد.
نتیجه‌گیری: نتیجه این فراتحلیل نشان می­دهد که درمان­های مبتنی بر ذهن آگاهی با استفاده از تکنیک­هایی چون توجه بر زمان حال و پذیرش بدون قضاوت هیجان­ها در بهبود نشانه­های افسردگی و اضطراب به­طور معنی دار و با اندازه اثر بالا موثر است.

واژه‌های کلیدی: فراتحلیل، ذهن آگاهی، افسردگی، اضطراب
ارزیابی کارایی فنی مراکز بهداشتی و درمانی با استفاده مدل ترکیبی تحلیل پوششی دادهها و نظریه بازی: مورد مطالعه مراکز بهداشتی درمانی شهرستان یزد
Authors: احمدآبادی حبیب زارع , مسعودیان سپیده , بنادکوکی محمدرضا زارع 
Published: December 2018

مقدمه: بهبود عملکرد مراکز بهداشتی درمانی به ارزیابی عملکرد آنها وابسته است. ارزیابی کارایی نسبی مراکز بهداشتی درمانی در طراحی نظام مدیریت عملکرد بهداشتی نقش موثری دارد.
روش بررسی: در این پژوهش از شیوه شبه آزمایشی مبتنی بر مدل سازی ریاضی برای شناسایی و بررسی رفتار متغیرهای تبیین گر کارایی مراکز بهداشتی استفاده شده است. ابتدا با بررسی پیشینه، ورودی‌ها و خروجی‌های مرتبط با عملکرد مراکز بهداشتی درمانی شناسایی گردید. سپس با کمک خبرگان حوزه‌های مختلف عملکردی، تناسب‌سنجی شاخص‌ها و داده های مورد نیاز صورت گرفت. با جمع‌آوری داده‌های مربوطه، زمینه مدل‌سازی ریاضی مبتنی بر شیوه تلفیقی DEA-Game مهیا شد و با کمک نرم‌افزارهای DEA-Solver و Lingo مدل‌های ریاضی مناسب طراحی و حل گردید.
نتایج: یافته ها حاکی از سطوح کارایی متفاوت و بعضاً تامل برانگیز بین مراکز بهداشتی درمانی شهرستان یزد می‌باشد. نتایج نشان می دهد که اغلب مراکز بهداشتی درمانی امتیاز ترکیبی بین 6/0 تا 9/0 داشته و تنها دو مرکز بهداشتی درمانی پنبه کاران و اکبری صفائیه در مرز کارا قرار دارند. هموار شدن امتیازها مؤید وجود ضعف‌های سیستمی و یکسان در مراکز بهداشتی درمانی می‌باشد. در اکثر حوزه های عملکردی نظیر بهداشت خانواده شامل کودکان، مادران باردار، زنان و سالمندان و بهداشت درصد تغییرات لازم در پرسنل بهداشت برای کاراشدن واحدها کمتر از سایر ورودی هاست.
نتیجه‌گیری: استفاده از مدل سازی ترکیبی مبتنی بر DEA-Game امکان تحلیل هم زمان کارایی مرکز بهداشتی درمانی را در هفت حوزه مختلف عملکردی فراهم می سازد. تحلیل توامان همکاری بین مراکز در ارتقاء کارایی کل سیستم بهداستی درمانی و رقابت بر بهره برداری بهتر از منابع، از ویژگی های متمایز استفاده از این شیوه می باشد که مورد تائید رسیده است.

واژه‌های کلیدی: مدیریت عملکرد، کارایی فنی، تحلیل پوششی داده‌ها، تئوری بازی‌ها، مراکز بهداشتی درمانی
The Antioxidant and Cytotoxic Effects of Cosmos caudatus Ethanolic Extract on Cervical Cancer
Authors: Nurhayati Betty , Rahayu Ira Gustira , Rinaldi Sonny Feisal , Zaini Wawan Sofwan , Afifah Ervi , Arumwardana Seila , Kusuma Hanna Sari Widya , Rizal Rizal , Widowati Wahyu 
Published: December 2018

BACKGROUND: Oxidative stress is closely related to all aspects of cancer. Cosmos caudatus ethanolic extract (CCEE) has been proved to have antioxidant effect that inhibited cancer cell growth due to its bioactive compounds such as catechin, quercetin and chlorogenic acid. This study aimed to evaluate antioxidant and anticancer activity of CCEE and its compounds.METHODS: Total phenol was measured according to the Folin-Ciocalteu method. Catechin, quercetin and chlorogenic acid contained in CCEE were identified by high-performance liquid chromatography (HPLC). Antioxidant activity was evaluated by 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)-reducing activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, and ferric reducing antioxidant power (FRAP) activity test. The cytotoxic activity of CCEE was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay on HeLa cells.RESULTS: The result showed that total phenol of CCEE was 181.64±0.93 µg Cathecin/mg extract. ABTSreducing activity test showed that catechin had the highest activity (2.90±0.04 µg/mL), while CCEE had moderate activity compared to other compounds. FRAP activity test demonstrated that catechin had the highest activity (315.83 µM Fe(II)/µg) compared to other compounds. DPPH scavenging activity of CCEE was 22.82±0.05 µg/mL. Cytotoxicity test on HeLa cell showed that CCEE had lower activity (inhibitory concentration (IC)50= 89.90±1.30 µg/mL) compared to quercetin (IC50 = 13.30±0.64 µg/ mL).CONCLUSION: CCEE has the lowest antioxidant activity compared to quercetin, catechin, and chlorogenic acid and has the lowest anticancer activity compared to quercetin. However, CCEE and its compounds has potential as antioxidant and anticancer properties.KEYWORDS: antioxidant, anticancer, catechin, Cosmos caudatus, quercetin