bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Tide Gauge Biases and Precision by the Combination of Multiple Collocated Time Series
Authors: Gobron Kevin , de Viron Olivier , Wöppelmann Guy , Poirier Étienne , Ballu Valérie , Van Camp Michel 
Published: August 2019

AbstractThis study proposes a method for the cross calibration of tide gauges. Based on the combination of at least three collocated sea level time series, it takes advantage of the least squares variance component estimation (LS-VCE) method to assess both sea level biases and uncertainties in real conditions. The method was applied to a multi-instrument experiment carried out on Aix Island, France, in 2016. Six tide gauges were deployed to carry out simultaneous sea level recordings for 11 h. The best results were obtained with an electrical contact probe, which reaches a 3-mm uncertainty. The method allows us to assess both the biases and the precision—that is, the full accuracy—for each instrument. The results obtained with the proposed combination method have been compared to that of a buddy-checking method. It showed that the combination of all the time series also provides more precise bias estimates.
Impact of Increased Vertical Resolution on Medium-Range Forecasts in a Global Atmospheric Model
Authors: Lee Eunjeong , Lee Eun-Hee , Choi In-Jin 
Published: August 2019

Abstract
This study aims to investigate the impact of increased vertical resolution on global medium-range forecasts. For this purpose, the dependencies of simulated atmospheric temperature and specific humidity on the lowest model level height and vertical grid spacing are investigated. The reduced first model level increases vertical turbulent mixing by determining a higher planetary boundary layer (PBL) height and associated turbulent diffusivities and velocity scales. This contributes to warming/drying within the PBL and cooling/moistening above the PBL. Resulting dryness near the surface enhances an increase in surface moisture flux from the ocean, which results in the apparent moistening of the troposphere. Consequently, large-scale precipitation increases due to more humid atmospheric conditions, while convective precipitation decreases because of drier conditions near the starting level of convection. Meanwhile, the reduced vertical grid spacing resolves the overshooting layer well in the cumulus convection process, which decreases the detrained moisture at the convective cloud top. This leads to a noticeable downward shift of ice clouds in the upper troposphere, and further contributes to the enhancement of longwave cooling via cloud–radiation processes. In medium-range forecasts, the increased vertical resolution exerts a significant impact on the simulated features of tropospheric temperature and humidity, while changes in the prediction accuracy precipitation are negligible owing to compensation between convective and large-scale precipitation. Finally, the discussion of possible methods to minimize the sensitivities of model’s physics to vertical resolution is presented.
Using a Coevolutionary Postprocessor to Improve Skill for Both Forecasts of Surface Temperature and Nowcasts of Convection Occurrence
Authors: Roebber Paul J. , Crockett John 
Published: August 2019

Abstract
An evolutionary programming postprocessor, using coevolution in a predator–prey ecosystem model, is developed and applied both to 72-h, 2-m temperature forecasts for the conterminous United States and southern Canada and to 60-min nowcasts of convection occurrence for the United States east of 94°W. The new approach improves deterministic and probabilistic forecasts of surface temperature relative to bias-corrected numerical weather prediction forecasts and to an earlier version of evolutionary programming forecasts for these same data. The new method also improves deterministic performance for an artificial neural network trained and evaluated for these same data. Additionally, the new approach substantially improves these forecasts’ reliability, as evidenced by reductions in the occurrence of excessive outliers in the rank histogram. The coevolutionary postprocessor also improves deterministic nowcasts of convection occurrence when compared to those produced by the National Weather Service’s AutoNowCaster system and to those obtained using multiple logistic regression. Notably, the degree of improvement relative to traditional methods appears to be problem dependent, while the training and implementation of such a system requires additional effort. However, the coevolutionary system is shown to be robust to imbalances between the frequency of positive and null events in the training data, unlike many postprocessing methods; to be implementable and effective in an adaptive mode, removing the need for retraining as inputs (such as numerical weather prediction model data) change; and to provide a useful, alternative perspective on the likelihood of event occurrence when used in combination with other methods.
Localized giant solitary fibrous tumor of the scrotum: a rare case report and literature review
Authors: Jiang Shuangjian , Yang Yun , Mo Chengqiang , Chen Lingwu , Qiu Shaopeng , Huang Bin , Chen Junxing 
Published: August 2019

Background A solitary fibrous tumor (SFT) is a fibroblastic mesenchymal tumor initially thought to originate from the pleura but that may arise at almost any anatomic site. It is mostly benign, and surgical resection is usually the best treatment option. An SFT involving the scrotum is extremely rare. Case presentation: We herein report an uncommon case of a 22-year-old man who presented with a huge asymptomatic scrotal mass that had begun growing 3 years before presentation. Contrast-enhanced computed tomography revealed a heterogeneous, well-circumscribed scrotal mass with soft tissue density. No invasion of the surrounding organs, distal metastasis, or lymph node swelling was present. Complete resection of the mass was successfully performed. The specimen was a 14.5 × 12.0 × 9.5 cm encapsulated tumor that weighed 970 g. After pathological analysis, we confirmed the diagnosis of SFT. This diagnosis was based on clinical findings, histological morphology, and immunohistochemistry. No recurrence or metastasis was observed during a 3-year follow-up. Conclusion SFTs have an unpredictable clinical course, and they are difficult to diagnose and easy to misdiagnose. A scrotal location is extremely rare. Complete resection of the mass is the treatment of choice and is associated with a high success rate and low recurrence rate.
Effect of fentanyl on nausea and vomiting in cesarean section under spinal anesthesia: a randomized controlled study
Authors: Shin Dong Wook , Kim Yeojung , Hong Boohwi , Yoon Seok-Hwa , Lim Chae Seong , Youn Sookyoung 
Published: August 2019

Objective Although opioids may induce nausea and vomiting, they possess sedative effects and can reduce intraoperative nausea and vomiting (IONV). This study assessed the effect of adding fentanyl to midazolam on sedation levels and IONV during cesarean section under spinal anesthesia. Methods Eighty parturients scheduled for elective cesarean section were enrolled in the study. Following fetal delivery, patients were administered 0.05 mg/kg of midazolam plus 0.03 mL/kg of normal saline (M group) or 0.05 mg/kg of midazolam plus 1.5 μg/kg of fentanyl (MF group). The primary outcome was the incidence of IONV. The secondary outcomes were incidence of postoperative nausea and vomiting (PONV), intraoperative sedation level, and five-point patient satisfaction score (PSS). Results The IONV incidence was significantly lower in the MF group compared with the M group (5% [2/40] vs. 25% [10/40]). The PONV incidence did not differ significantly between the groups. The intraoperative sedation level tended to be deeper in the MF group. The 5-point PSS was significantly higher in the MF group. There was a strong correlation between the sedation level and IONV incidence. Conclusions Adding fentanyl to midazolam is effective for sedation and to prevent IONV in women who are undergoing cesarean section under spinal anesthesia.
Addressing the specialist workforce CAMH skill-gap: providing and evaluating iCAMH training in Fiji and Papua New Guinea
Authors: Hoadley Benjamin , Gaikwad Kiran , Allen Myrielle , Kowalenko Nick , Chang Odille 
Published: August 2019

Objective:Child and adolescent mental health problems are common and result in significant morbidity. Whereas in high-income countries there is an established workforce, in lower income countries, such as the Pacific nations, the workforce has little capacity despite a potentially higher population risk of mental disorder. We report on a workforce development effort, a child and adolescent mental health training package.Method:We describe the implementation and evaluation of the International Child and Adolescent Mental Health certificate training in two Pacific nations.Results:Clinicians rated the training positively. Some participants reported concern with teaching materials. Attitudes to child and adolescent mental health were more favourable following the course. A change in knowledge or skill could not be determined.Conclusions:The training seems of value to Pacific clinicians and the framework provides for case-based learning across settings. The training would benefit from the addition of a valid assessment of participant skill and knowledge. The sociocultural and contextual factors are considerations for the content and delivery. Contextually appropriate resources and teaching strategies are important.
Loss in efficacy measures of tolfenamic acid in a tau knock-out model: Relevance to Alzheimer’s disease
Authors: Leso Allison , Bihaqi Syed W , Masoud Anwar , Chang Joanna K , Lahouel Asma , Zawia Nasser 
Published: August 2019

In the healthy human brain, the protein tau serves the essential function of stabilizing microtubules. However, in a diseased state, tau becomes destabilized and aggregates into a pathogenic form that ultimately creates one of the two major hallmarks of Alzheimer’s disease (AD), tau tangles. Multiple neurodegenerative diseases, termed tauopathies, such as Pick’s disease, and progressive supranuclear palsy, are also linked to mutations in tau. While AD does include a second hallmark in the form of amyloid beta (Aβ) plaques, to date all therapeutics aimed at these hallmark features have failed. The nonsteroidal anti-inflammatory drug tolfenamic acid (TA) has been shown to reduce the levels of multiple neurodegenerative endpoints viz amyloid precursor protein (APP), Aβ, tau, phosphorylated tau (p-tau) and improve cognitive function, in various murine models, via a new mechanism that targets specificity protein 1 ( SP1). Sp1 is a zinc-finger transcription factor essential for the regulation of tau and CDK5 genes (among others). The impact of TA on these neurodegenerative endpoints occurred in animal models and systems in which both the tau and the APP genes were present. The experimental model utilized in this paper tested whether the same beneficial outcomes of TA can take place after the removal of endogenous murine tau. We found that the impact of TA, both molecular and behavioral, was no longer significant in the absence of the tau gene. This ability of TA occurred independently of its action on anti-inflammatory targets. Therefore, these findings suggest the essentiality of tau for the novel mechanism of action of TA.Impact statementThe number of people suffering from Alzheimer’s disease (AD) is expected to increase exponentially in the coming decades. It is estimated to cost the economy about $200 billion annually. With the failure of standard therapeutic approaches, there is a need to develop new drugs in order to avoid an “epidemic crisis” in the future. We have discovered that tolfenamic acid (TA) lowers the levels of proteins associated with AD, by targeting common transcriptional mechanisms that regulate genes involved in common pathogenic pathways. Here, we investigated whether TA had effects on both the amyloid and tau pathways, or whether it selectively targets one of these pathways which impacted the other. Behavioral and molecular studies revealed that TA loses its AD therapeutic potential when tau gene is removed. This ability of TA occurred independently of its action on anti-inflammatory targets. These findings suggest that tau is essential for the new action of TA.
Detachable balloon embolization as the preferred treatment option for traumatic carotid-cavernous sinus fistula?
Authors: Niu Yin , Chen Tunan , Tang Jun , Jiang ZhouYang , Zhu Gang , Chen Zhi 
Published: August 2019

Objective The purpose of the study was to investigate the treatments and outcomes of patients with traumatic carotid-cavernous sinus fistula (TCCF). Methods All patients diagnosed with TCCF at our institution from January 2013 to December 2018 and meeting the inclusion/exclusion criteria were included in the study. Results A total of 24 patients were included in this study. Of them, 21 (87.5%) were treated with detachable balloon embolization, 1 (4%) with coil embolization, 1 (4%) with balloon-assisted coil embolization, and 1 (4%) with balloon-assisted coil and glue embolization. Among the 21 patients treated with detachable balloon embolization, 10 underwent double-balloon technique embolization including double-detachable balloon embolization (n = 6) and balloon-assisted detachable balloon embolization (n = 4). The fistulas in 17 patients (17/21, 81%) were successfully occluded after the first attempt of detachable balloon embolization, while those in the remaining 4 patients were occluded after a second surgery due to TCCF recurrence or pseudoaneurysm development. Preservation of the internal carotid artery (ICA) was observed in 19 cases after the first treatment by detachable balloon embolization (19/21, 90.4%). ICA was occluded in the remaining two patients, as revealed by a complete angiographic evaluation of the circle of Willis. All patients achieved complete resolution of ocular and orbital manifestations as well as pulsatile bruit, except for three patients whose oculomotorius and/or abducens remained paralyzed during the follow-up period. Conclusion Although several endovascular treatment options are available for TCCF, the detachable balloon embolization is still the preferred method of TCCF, as evidenced in our study. Furthermore, double balloon technique, an improvement upon the conventional detachable balloon embolization, is extremely safe and can effectively treat patients with refractory TCCF.
Endoplasmic reticulum stress promoting caspase signaling pathway-dependent apoptosis contributes to bone cancer pain in the spinal dorsal horn
Authors: He Qiuli , Wang Tingting , Ni Huadong , Liu Qianying , An Kang , Tao Jiachun , Chen Yajing , Xu Longsheng , Zhu Chunyan , Yao Ming 
Published: August 2019

Background Management of bone cancer pain is difficult because of its complex mechanisms, which has a major impact on the quality of patients’ daily life. Recent studies have indicated that endoplasmic reticulum stress is involved in many neurological and inflammatory pathways associated with pain. However, the factors that contribute to endoplasmic reticulum stress and its causes in bone cancer pain are still unknown. In this study, we examined whether the endoplasmic reticulum stress response is involved in caspase signaling pathway-dependent apoptosis in neurons in the spinal dorsal horn of tumor-bearing rats and whether it thereby induces bone cancer pain. Methods Bone cancer pain was measured behaviorally by the paw withdrawal threshold. The expression levels of endoplasmic reticulum stress markers, namely, immunoglobulin-binding protein/glucose-regulated protein 78 (BIP/GRP78), activating transcription factor-6 (ATF6), phosphorylated inositol-requiring enzyme-1 (p-IRE1), phosphorylated protein kinase RNA-like endoplasmic reticulum kinase (p-PERK) and cleaved caspase-3, were quantitatively assessed by western blot. The distribution of p-eIF2α (an endoplasmic reticulum marker) and cleaved caspase-3 in the lumbar enlargement of the spinal cord was determined by immunohistochemistry in spinal dorsal horn slices. Results Bone cancer pain suffered bone damage and persistent mechanical allodynia. Bone cancer pain increased the expression of GRP78, ATF6, p-PERK, p-IRE1, and cleaved caspase-3 in a rat model of bone cancer pain. In addition, p-eIF2α and cleaved caspase-3 were localized to neurons. The intrathecal injection of tauroursodeoxycholic acid as a specific inhibitor of endoplasmic reticulum stress attenuated bone cancer pain and reduced the expression of GRP78, ATF6, p-PERK, p-IRE1, and cleaved caspase-3 in the spinal cord. Moreover, Z-DEVD-FMK (FMK) was also shown to attenuate bone cancer pain. Conclusion Endoplasmic reticulum stress causes the activation of caspase signaling pathway-dependent apoptosis in neuronal cells and induces bone cancer pain-related hyperalgesia.
Vulnerability to cardiac arrest in patients with ST elevation myocardial infarction: Is it time or patient dependent? Results from a nationwide observational study
Authors: Salah Mahadi , Gevaert Sofie , Coussement Patrick , Beauloye Christophe , Sinnaeve Peter R , Convens Carl , De Raedt Herbert , Dens Jo , Pourbaix Suzanne , Saenen Johan , Claeys Marc J 
Published: August 2019

Aim:
Cardiac arrest is a common complication of ST elevation myocardial infarction and is associated with high mortality. We evaluated whether vulnerability to cardiac arrest follows a circadian rhythm and whether it is related to specific patient characteristics.

Methods:
A total of 24,164 ST elevation myocardial infarction patients who were admitted to 60 Belgian hospitals between 2008–2017 were analysed. The proportion of patients with cardiac arrest before initiation of reperfusion therapy was calculated for different time periods (hour of the day, months, seasons) and related to patient characteristics using stepwise logistic regression analysis.

Results:
Cardiac arrest occurred in 10.8% of the ST elevation myocardial infarction patients at a median of 65 min (interquartile range 33–138 min) after onset of pain. ST elevation myocardial infarction patients with cardiac arrest showed a biphasic pattern with one peak in the morning and one peak in the late afternoon. Multivariate analysis identified the following independent factors associated with cardiac arrest: cardiogenic shock (odds ratio=28), left bundle branch block (odds ratio=3.7), short (&lt;180 min) ischaemic period (odds ratio=2.2), post-meridiem daytime presentation (odds ratio=1.4), anterior infarction (odds ratio=1.3). Overall in-hospital mortality was 30% for cardiac arrest patients versus 3.7% for non-cardiac arrest patients (p&lt;0.0001).

Conclusion:
In the present study population, cardiac arrest in ST elevation myocardial infarction showed an atypical circadian rhythm with not only a morning peak but also a second peak in the late afternoon, suggesting that cardiac arrest and ST elevation myocardial infarction triggers are, at least partially, different. In addition, specific patient characteristics, such as short ischaemic period, cardiogenic shock and left bundle branch block, increase the vulnerability to cardiac arrest.
Intralesional excision as a surgical strategy to manage keloid scars: what’s the evidence?
Authors: Goutos Ioannis 
Published: August 2019

Introduction: Keloid scars are a particularly challenging clinical entity and a variety of management approaches have been described in the literature including intralesional surgery. The current literature lacks a summative review to ascertain the evidence base behind this surgical approach. Methods: A comprehensive English literature database search was performed using PubMed Medline, EMBASE and Web of Science from their individual dates of inception to March 2018. We present the different rationales proposed for the use of this technique, the clinical outcomes reported in the literature as well as the scientific basis for intralesional excision of keloid scars. Discussion: A number of arguments have been proposed to support intralesional excision including avoiding injury to neighbouring non-keloidal skin and the deep layer of the dermis, removal of the most proliferative fibroblastic group as well as debulking to facilitate the administration of injectable steroid. The most current literature does not provide sufficient support for the adoption of intralesional excisions based on data emerging from basic science as well as clinical outcome studies. Conclusion: Emerging evidence supports the extralesional excision of keloid scars based on current mechanobiological, histological as well as clinical outcome data. Further trials comparing extralesional and intralesional surgical practices are eagerly awaited to ascertain the role of intralesional excisions in the keloid management arena.
Assessment of lower limb rotational profile and its correlation with the tibial tuberosity-trochlea groove distance: A radiological study
Authors: Thakrar Raj R , Al-Obaedi Ossama , Theivendran Kanthan , Snow Martin 
Published: August 2019

Objective: The purpose of our study was to determine whether there is a correlation between the lower limb rotational profile and tibial tuberosity-trochlea groove (TT-TG) distance. Design and patients: The computed tomography cross-sectional imaging on 50 patients’ lower limbs (100 limbs) was investigated at our institution. The TT-TG distance was measured along with rotational measurements including femoral version (FV), tibial torsion and knee joint rotation angle (KJRA). Patients were divided into two groups. Group 1 had a TT-TG ≥ 20 mm which was considered pathological and group 2 with a non-pathological TT-TG (≤19 mm). Rotational angles were compared between groups. Statistical analysis was performed using the t-test and Mann–Whitney U analysis. Results and conclusions: Our results demonstrated a statistically significant difference in the mean KJRA ( p = 0.026) between the pathological (mean = 10.6, standard deviation (SD) = 7.79°) and the non-pathological TT-TG groups (mean = 6.99, SD = 5.06°). A higher mean value for FV and tibial torsion was also demonstrated in patients with a pathological TT-TG (18.2 vs. 13.7, 32.8 vs. 30.9, p > 0.05, respectively). In conclusion, there was a statistically significant higher mean value for the KJRA in patients with a pathological TT-TG. Hence, a lateralized tibial tubercle as demonstrated by an increase in the TT-TG distance may be associated with a coexisting lower limb rotational malalignment.