bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Preoperative Chemoradiotherapy with Oxaliplatin, Infusional 5-Fluorouracil, and Cetuximab Followed by Postoperative Docetaxel and Cetuximab in Patients with Adenocarcinoma of the Esophagus: A Trial of the ECOG-ACRIN Cancer Research Group (E2205)
Authors: Gibson Michael K. , Catalano Paul , Kleinberg Lawrence R. , Staley Charles A. , Montgomery Elizabeth A. , Jimeno Antonio , Song Wei (Frank) , Mulcahy Mary F. , Leichman Lawrence P. , Benson Al B. 
Published: June 2019

Abstract

Background
A standard approach to treating resectable esophageal adenocarcinoma is chemoradiotherapy (CRT) followed by surgery; however, recurrence is common. To improve this, we designed a single-arm, phase II trial that added an epidermal growth factor receptor (EGFR) inhibitor, cetuximab (C), to CRT, with the hypothesis that EGFR inhibition would improve pathologic complete response (pCR) rate.

Materials and Methods
We aimed to increase the pCR rate from 25% to 45%. A Simon two-stage design (α and β of 0.10) required pCR/enrolled 5/18 for stage 1 and 14/40 total. CRT: oxaliplatin 85 mg/m2 days 1, 15, and 29; infusional 5-fluorouracil 180 mg/m2/24 hours × 35 days; C 400 mg/m2 day 1 then 250 mg/m2 days 8, 15, 22, and 29 and radiation (intensity modulated radiotherapy [IMRT] allowed) 180 cGy/day × 25 fractions (Monday through Friday). Following esophagectomy, adjuvant chemotherapy (CT): weekly docetaxel 35 mg/m2 and C 250 mg/m2 5 out of 6 weeks for two cycles.

Results
Of 21 eligible patients enrolled, 17 had surgery; 4 died before operation (due to pulmonary embolism 4 days after CRT, G3 diarrhea, progressive disease during CRT, sepsis/hypoxia during CRT, and acute respiratory distress syndrome [ARDS]). pCR = 7/17. Three postoperative deaths due to ARDS resulted in seven total study-related deaths. Of the 14 remaining patients, 12 started and completed adjuvant CT. Two of seven patients with pCR died, both of ARDS. Out of the 21 eligible subjects in this study, 13 have died and 8 remain alive. The use of IMRT did not correlate with ARDS.

Conclusion
This regimen demonstrated promising activity. Toxicity was significant, with seven study-related deaths leading to closure after stage 1. All postoperative deaths were due to ARDS. This regimen is not recommended.
Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation
Authors: Wehbi Batoul , Oblet Christelle , Boyer François , Huard Arnaud , Druilhe Anne , Paraf François , Cogné Etienne , Moreau Jeanne , El Makhour Yolla , Badran Bassam , Van Egmond Marjolein , Cogné Michel , Aldigier Jean-Claude 
Published: June 2019

Significance Statement
IgA nephropathy (IgAN) is characterized by IgA glomerular mesangial deposition, but its pathogenesis remains unclear. Using humanized transgenic mouse models, the authors explored whether a hypogalactosylated hinge region (found in most mesangial IgA1 in human IgAN) is required for IgA deposition, demonstrating that hinge hypoglycosylation was not mandatory for deposition. To investigate whether low-affinity IgA produced by innate-like B cells might also yield mesangial deposits, they compared mice able to produce high-affinity mature IgA antibodies with mice lacking affinity maturation. They found that the low-affinity IgA can deposit in the mesangium and activate complement, that it is especially prone to induce glomerular cell thickening, and that it can initiate nephrotoxicity. These findings offer a new perspective regarding glomerular IgA deposits involving innate-like antibody responses.

Background
IgA nephropathy (IgAN) often follows infections and features IgA mesangial deposition. Polymeric IgA deposits in the mesangium seem to have varied pathogenic potential, but understanding their pathogenicity remains a challenge. Most mesangial IgA1 in human IgAN has a hypogalactosylated hinge region, but it is unclear whether this is required for IgA deposition. Another important question is the role of adaptive IgA responses and high-affinity mature IgA antibodies and whether low-affinity IgA produced by innate-like B cells might also yield mesangial deposits.

Methods
To explore the effects of specific qualitative variations in IgA and whether altered affinity maturation can influence IgA mesangial deposition and activate complement, we used several transgenic human IgA1-producing models with IgA deposition, including one lacking the DNA-editing enzyme activation-induced cytidine deaminase (AID), which is required in affinity maturation. Also, to explore the potential role of the IgA receptor CD89 in glomerular inflammation, we used a model that expresses CD89 in a pattern observed in humans.

Results
We found that human IgA induced glomerular damage independent of CD89. When comparing mice able to produce high-affinity IgA antibodies with mice lacking AID-enabled Ig affinity maturation, we found that IgA deposition and complement activation significantly increased and led to IgAN pathogenesis, although without significant proteinuria or hematuria. We also observed that hinge hypoglycosylation was not mandatory for IgA deposition.

Conclusions
In a mouse model of IgAN, compared with high-affinity IgA, low-affinity innate-like IgA, formed in the absence of normal antigen-driven maturation, was more readily involved in IgA glomerular deposition with pathogenic effects.
Kış Turizmi Destinasyonlarının Algılanan Performansı: Türkiye’deki Beş Destinasyonun Kıyaslaması
Authors: EVREN Savaş , KOZAK Nazmi 
Published: June 2019

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Kış turizmi pazarı, dünyada en hızlı büyüyen turizm pazarlarından biridir. Türkiye’de ise özellikle 2000’lerin başından itibaren hem arz hem de talep anlamında önemli gelişmeler yaşanmaktadır. Ancak Türkiye’deki kış turizmi destinasyonlarını, ziyaretçi algıları çerçevesinde inceleyen araştırma sayısı oldukça azdır. Bu çalışma, Türkiye’nin beş rekabetçi kış turizmi destinasyonunun (Erciyes, Kartalkaya, Kartepe, Palandöken, Uludağ) yerli ziyaretçilerce algılanan performansının karşılaştırmalı bir şekilde ortaya konması amacıyla gerçekleştirilmiştir. Veri toplamak amacıyla anket tekniğinin kullanıldığı çalışmada, performans değerlendirmeleri için önem-performans analizinden yararlanılmıştır. Bulgular, ilgili destinasyonlar arasında algılanan performansı en yüksek olanın Erciyes olduğunu göstermiştir. Diğer dört destinasyon arasındaki performans sıralaması ise yüksekten düşüğe doğru; Palandöken, Uludağ, Kartalkaya, Kartepe şeklindedir. Uludağ ve Kartalkaya’da fiyat ve pist yoğunluğuna ilişkin maddelerin; Palandöken’de güvenlik ve fiyata ilişkin maddelerin; Kartepe’de ulaşım ve manzara dışındaki tüm maddelerin destinasyon yöneticilerinin öncelik vermesi gereken maddeler olduğu bulunmuştur. Erciyes’te ise öncelikli olarak iyileştirilmesi gereken bir madde bulunmamıştır.
Effects of the different anesthetic methods on postoperative hospitalization and use of analgesia in varicocele surgery
Authors: BORAN Ömer Faruk , KANDİLCİK Mehmet , TÜRKAY Bekir , KATI Bülent , DEMİRKOL Mehmet Kutlu , BARUT Osman , ORAK Yavuz , ÇALIŞIR Feyza 
Published: June 2019

Objective: The aim of this study was to
evaluate the effect of different anesthetic methods used in varicocele surgery
on postoperative pain relief needs and duration of hospitalization.Material and Methods: This study included 299 patients
operated with varicocele between 2014 and 2018.
patients were divided into general anesthesia+local anesthesia (20 ml
prilocaine (2%)) skin infiltration [general anesthesia group (Group 1, n=50)],
patients only administered spinal anesthesia [spinal anesthesia group (Group 2,
n=142)], patients administered spinal anesthesia+TAP block [spinal+TAP block
group (Group 3, n=52)] and patients administered spinal anesthesia and
intrathecal morphine [spinal+ITM group (Group 4, n=55)].Results: The
analgesic use in the general anesthesia group was not different from the spinal
anesthesia group (p&gt;0.05), but was different compared to the spinal+TAP
group and spinal+ITM group (p&lt;0.05, for both). Postoperative analgesic use is assessed for
patients, the general anesthesia group was observed to have significantly
shorter time for first analgesic use compared to the other groups (p=0.001).
When patients are assessed in terms of the cost of anesthetic method, the
highest cost method was in the spinal+TAP group.

Conclusion: Despite relatively high cost of
administration of spinal anesthesia+TAP block for varicocele surgery, it is an
effective and reliable method with lower analgesic requirements and shorter
duration of hospital stay.
Cambio estructural de la vocación agrícola y pecuaria en el municipio de Purificación, Tolima, Colombia
Authors: Sánchez Jiménez Wilson , Nieto Gómez Libia Esperanza , Giraldo Díaz Reinaldo 
Published: June 2019

En el municipio de Purificación, Tolima, Colombia, las economías basadas en el monocultivo del arroz y la explotación de hidrocarburos son los principales renglones de las actividades productivas. Este modelo extractivista ha generado un cambio abrupto en el uso y tenencia de la tierra; en los modos de vida de las comunidades y en las transformaciones de las relaciones sociales de este territorio. Además, el conflicto social y armado colombiano se constituyó en uno de los escenarios del despojo sistemático de la tierra. Metodológicamente, se analiza críticamente la Visión 2025 del departamento del Tolima, contrastándola con las mejores prácticas de la literatura y con observaciones en la zona, para desarrollar una postura crítica desde la perspectiva de las comunidades y la sociedad. Se pudo visibilizar el progresivo cambio estructural de la vocación agrícola y pecuaria de una agricultura familiar campesina a un modelo de economía extractivista. Se concluye que el acaparamiento de la tierra se constituye en un verdadero obstáculo para la pervivencia de las economías campesinas y sus modos de vida, su cultura y sus procesos identitarios ligados al uso comunitario de la tierra. Pese a la existencia de políticas públicas enfocadas al desarrollo de las comunidades rurales y cuidado de los ecosistemas, los entes territoriales están lejos de lograr dar respuesta a la gravísima situación de las comunidades rurales. La actual configuración del uso y tenencia de la tierra en el municipio de Purificación, permite comprender lo inicuas que han sido las políticas públicas en el campo colombiano.
Intervención sistémica con familias: de la linealidad a la circularidad
Authors: Páez-Cala Martha Luz 
Published: June 2019

This is an applied research carried out in a formative context of systemic orientation in postgraduate studies. The objective was to identify some factors that favor the transition from a linear thinking to a circular one characteristic of the systemic task, which operates through feedback loops to enhance change, in therapists and consultants, both teachers and students in training. Methodology: It was carried out through focus groups and indepth interviews in reflective conversational settings. Participants: three lecturers of theoretical-practical seminars and seven students of the Specialization in Psychotherapy and Systemic Consultancy of the University of Manizales. Results: Three novelties were identified in the experiences of systemically oriented psychologists: linear and circular thinkings do not appear isolated or exclusive, they can be transposed from one to another. This constitutes an adventure facilitated by the need to articulate human dilemmas in a context of relational responsibility, which implies the self-reference of the intervener. Participants agree on basic factors and relieve the mainstreaming from the cognitive, emotional, and pragmatic sphere in this transit, also, highlight an innovative movement at the time of immersing in logics of circular nature.
En medio de la violencia: recursos, tácticas y violencia contra el sector ganadero
Authors: Ponce de León-Calero Alejandro 
Published: June 2019

This article discusses the main results of a research study on the interactions between stockbreeders and armed groups in relation to the illegal collection of funds, as narrated in the stockbreeders’ testimonies and memories. The paper relies on both statistical and narrative analysis methodologies in order to explore the patterns and configurations in interactions with armed groups. It is argued here that the stockbreeders were not supporters or passive victims, rather they acted strategically when making decisions and relying on social and financial capitals actors to negotiate the terms of their own subjugation. Drawing upon studies on remembrance and historicization of the Colombian armed conflict, the paper stresses the need to understand local contexts, taken as spaces of uncertainty, agitation, and ongoing readjustment. The paper also cautions scholars against the tendency to reduce the interactions between civilians and armed groups to mere economic or political motivations. Rather, these interactions are considered to emerge mainly from individuals’ everyday concerns and the desire to protect their lives.
Factors associated with atrial fibrillation in patients with hypertension and preserved left ventricle systolic function
Authors: Tlegenova Zh. Sh. , Zholdin B. K. , Kudaiberdieva G. Z. , Abdrakhmanov A. S. 
Published: June 2019

The objective of our study was to define factors associated with atrial fibrillation (AF) in patients with hypertension (HTN) and preserved left ventricle systolic function.Material and methods. Overall, 273 consecutive patients with HTN residing in urban area were included in the study. Patients were divided into 2 groups: the first – 60 patients with paroxysmal and persistent AF (33% men, age 62, 28 (10,02), the second – 213 patients without AF (33% men, age 59,37 (8,27).Results. Stepwise logistic regression analysis demonstrated AF presence was associated with alcohol intake ≥ 7 drinks per week (OR 4,12; 95%CI: 1,04–16,35), low physical activity (OR 3,18; 95% CI: 1,32–7,68), higher hip circumference (OR 1,19; 95% CI: 1,08–1,31) and history of HTN (OR 1,10; 95% CI: 1,04–1,17). BMI was not associated with presence of AF (OR 0,75; 95% CI: 0,61–0,91).Conclusion. Thus in our urban population with hypertension, AF is associated with alcohol intake ≥ 7 drinks per week, low physical activity, increased hip circumference and history of hypertension.AF prevention should include modification of lifestyle.
THE EFFECTIVENESS OF GOOGLE CLASSROOM AS AN INSTRUCTIONAL MEDIA: A CASE OF STATE ISLAMIC INSTITUTE OF KENDARI, INDONESIA
Authors: Alim Nur , Linda Wa , Gunawan Fahmi , Md Saad Mohd Shamsuri 
Published: June 2019

Purpose: This study aims to explore the effectiveness of Google Classroom in the learning process at the State Islamic Institute of Kendari.
Methodology: The research method used in this study is a qualitative method, in-depth interview. Data collection was done through interview sessions with students from the Faculty of Teacher Training and Education.
Main Findings: The findings showed that the use of Google Classroom was effective with various limitations: (1) not all students got an account what was provided by the lecturers because they did not have a smartphone, (2) Wi-Fi availability in the campus was limited and (3) the students did not have enough mobile data plan during the time of online discussion and even some students submitted their assignments using their friends’ account.
Applications of this study: The study will allow future initiatives to take into consideration the issues and challenges related to accessibility, connectivity and affordability among the users of the platform, in this case the students.
Novelty/Originality: This study provides valuable insights into the initiatives taken by the institutions of higher education in Indonesia that lack a proper platform for implementing e-learning. Issues and challenges found in this study contribute to making important strategic decisions when designing and implementing such initiatives in the future.
THE ARTS OF SOCIAL REALITY (RE) CONSTRUCT INDIVIDUAL MINDSET OF POST-INDEPENDENCE COMMUNITY VIA HISTORICAL DOCUMENTARY
Authors: Shahizan Ali Mohd Nor , Mohamed Salim Neesa Ameera 
Published: June 2019

Purpose of the study: The aim of this study is to analyse the meaning construction of the post-independence communities based on a historical documentary “Big Kitchen (1952)” which focuses on the literacy aspect of how an individual construe, implement and adapt technology in constructing meaning in line with the rapid development of the country.
Methodology: A focus group discussion was conducted which involved twenty-one informants from an Institute of Higher Learning in Malaysia. The discussion focuses on how the post-independence communities collectively construct their institutional knowledge by linking these three main areas; literacy, meaning construction and technology based on the historical documentary which consequently reveals the social reality of the community.
Main Findings: Findings revealed thatthere is a culture change (in Malaysia) due to migration, technological advancement, and rapid urbanization based on the meanings constructed by the post-independence communities. The combination of migration, technological development, and rapid urbanization have caused the informants to not be influenced by media materials that are shown but assess material based on the understanding and withholding long underlying themselves over the years.
Applications of this study: Since the media and communication studies is an established academic discipline in today’s digital era, this study is beneficial in contributing to the development of mass media and communication field specifically in the area of media literacy/ broadcasting literacy as the study covers the art of scientific investigation of the media.
Novelty/Originality of this study: This study justifies how media research and the technological shift in the media landscape affects the arts of social reality and the meaning construction of the post-independence communities in Malaysia via the “Big Kitchen (1952)” documentary. Findings revealed in this study contribute to the current debate of the current media issues, and to the development of mass media and communication field.
Understanding the Mutual Partner Dynamic of Intimate Partner Violence: A Review
Authors: Dokkedahl Sarah , Elklit Ask 
Published: June 2019

IntroductionBidirectional violence is not a recent phenomenon. Nonetheless, little attention has been given to the actual dyads of intimate violence. The aim of the present review is therefore to identify and examine research that involves both the male and female partner of couples experiencing problems with intimate partner violence (IPV).MethodA thorough literature search was conducted in the electronic databases PubMed and PsycINFO. This review includes only peer-reviewed articles conducting quantitative data analysis. The key inclusion criteria were the concept of bidirectional violence. Therefore, this review only includes studies where both partners participated in the study. A total of 70 studies were included.ResultsA wide variety of psychological, social, and interaction variables were identified. Especially challenges related to alcohol, attachment, communication, jealousy, mental health and relationship satisfaction were identified. Results sheds light on how conflicts escalate and are important aspects of how IPV patterns are developed.DiscussionThe present review demonstrates the importance of incorporating partner dynamics into our understanding of IPV. By putting less emphasis on the prevalence rates and instead focus more on the dynamics of the relationships, IPV appears to be a symptom of a variety of problems within the dyad. Therefore, it would be beneficial to target preventive efforts and interventions towards both members of the couple to directly address the unhealthy dynamics that are contributing to a pattern of IPV.
The items in the Chinese version of the Montreal Cognitive Assessment Basic discriminate among different severities of Alzheimer’s disease
Authors: Zhang Yan-rong , Ding Yun-Long , Chen Ke-liang , Liu Yan , Wei Can , Zhai Ting-ting , Wang Wen-Juan , Dong Wan-Li 
Published: June 2019

Abstract
Background
To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD).
Methods

MCI (n=456), mild AD (n=502) and moderate-severe AD (n=102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China. NC (n=329) were recruited from health checkup outpatients. Five MoCA-BC item scores were collected in interviews.
Results
The MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. The delay recall memory test had high sensitivity and specificity for MCI screening. The verbal fluency test was efficient for detecting MCI and differentiating AD severity.
Conclusions
Various items of the MoCA-BC can identify MCI patients early and identify the severity of dementia.
SMRT Sequencing of a Full-length Transcriptome Reveals Transcript Variants Involved in C18 Unsaturated Fatty Acid Biosynthesis and Metabolism Pathways at Chilling Temperature in Pennisetum giganteum
Authors: Li Qingyuan , Xiang Conglin , Xu Lin , Cui Jinghua , Fu Shao , Chen Baolin , Yang Shoukun , Wang Pan , Xie Yanfeng , Wei Ming , Wang Zhanchang 
Published: June 2019

Abstract
Background

Pennisetum giganteum, an abundant, fast-growing perennial C4 grass that belongs to the genus Pennisetum, family Poaceae, has been developed as a source of biomass for mushroom cultivation and production, as a source of forage for cattle and sheep, and as a tool to remedy soil erosion. However, having a chilling-sensitive nature, P. giganteum seedlings need to be protected while overwintering in most temperate climate regions.

Results

To elucidate the cold stress responses of P. giganteum, we carried out comprehensive full-length transcriptomes from leaf and root tissues under room temperature (RT) and chilling temperature (CT) using PacBio Iso-Seq long reads. We identified 196,124 and 140,766 full-length consensus transcripts in the RT and CT samples, respectively. We then systematically performed functional annotation, transcription factor identification, long non-coding RNAs (lncRNAs) prediction, and simple sequence repeat (SSR) analysis of those full-length transcriptomes. Moreover, isoform analysis revealed that alternative splicing events may be induced by cold stress in P. giganteum, and transcript variants may be involved in C18 unsaturated fatty acid biosynthesis and metabolism pathways at chilling temperature in P. giganteum.

Conclusions

We provide the first comprehensive full-length transcriptomic resource for the abundant and fast-growing perennial grass Pennisetum giganteum. Our results provide a useful genomic resource for exploring the biological pathways involved in the cold stress responses of P. giganteum.