bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe
Authors: Fröhlich Hanna , Rosenfeld Niklas , Täger Tobias , Goode Kevin , Kazmi Syed , Hole Torstein , Katus Hugo A , Atar Dan , Cleland John G F , Agewall Stefan , Clark Andrew L , Frankenstein Lutz , Grundtvig Morten 
Published: February 2019

ObjectiveTo describe the epidemiology, long-term outcomes and temporal trends in mortality in ambulatory patients with chronic heart failure (HF) with reduced (HFrEF), mid-range (HFmrEF) or preserved ejection fraction (HFpEF) from three European countries.MethodsWe identified 10 312 patients from the Norwegian HF Registry and the HF registries of the universities of Heidelberg, Germany, and Hull, UK. Patients were classified according to baseline left ventricular ejection fraction (LVEF) and time of enrolment (period 1: 1995–2005 vs period 2: 2006–2015). Predictors of mortality were analysed by use of univariable and multivariable Cox regression analyses.ResultsAmong 10 312 patients with stable HF, 7080 (68.7%), 2086 (20.2%) and 1146 (11.1%) were classified as having HFrEF, HFmrEF or HFpEF, respectively. A total of 4617 (44.8%) patients were included in period 1, and 5695 (55.2%) patients were included in period 2. Baseline characteristics significantly differed with respect to type of HF and time of enrolment. During a median follow-up of 66 (33–105) months, 5297 patients (51.4%) died. In multivariable analyses, survival was independent of LVEF category (p>0.05), while mortality was lower in period 2 as compared with period 1 (HR 0.81, 95% CI 0.72 to 0.91, p<0.001). Significant predictors of all-cause mortality regardless of HF category were increasing age, New York Heart Association functional class, N-terminal pro-brain natriuretic peptide and use of loop diuretics.ConclusionAmbulatory patients with HF stratified by LVEF represent different phenotypes. However, after adjusting for a wide range of covariates, long-term survival is independent of LVEF category. Outcome significantly improved during the last two decades irrespective from type of HF.
Pregnancy in women with pre-existent ischaemic heart disease: a systematic review with individualised patient data
Authors: Lameijer Heleen , Burchill Luke J , Baris Lucia , Ruys Titia PE , Roos-Hesselink Jolien W , Mulder Barbara J M , Silversides Candice K , van Veldhuisen Dirk J , Pieper Petronella G 
Published: February 2019

IntroductionStudies on pregnancy risk in women with ischaemic heart disease (IHD) have mainly excluded pregnancies in women with pre-existent IHD. There is a need for better information about the pregnancy risks in these women and their offspring.MethodsWe performed a systematic review searching the PubMed/MEDLINE public database for pregnancy in women with pre-existent IHD analysing the cardiac, obstetric and fetal/neonatal outcome of pregnancy in women with pre-existing IHD. Individual patient data were requested from large series. The primary outcome endpoints was a composite of ischaemic complications including maternal death, acute coronary syndrome and ventricular tachycardia.Results116 women with pre-existent IHD had 124 pregnancies including one twin pregnancy. They had a 21% chance of having an uncomplicated pregnancy (completed pregnancy without cardiovascular, obstetric or fetal/neonatal complications, n=26). Primary (ischaemic) endpoints occurred in 9% (n=11). Women with atherosclerosis had more cardiovascular complications compared with pregnancies in women with other underlying pathology for IHD (50%vs23%, P=0.02) but no significant difference in occurrence of primary endpoints (13% vs 9%, P=0.53). There were two maternal cardiac deaths (2%), one of which occurred in the 18th week of pregnancy and the other postpartum. Obstetric complications occurred in 58% (n=65) of pregnancies and fetal/neonatal complications in 42% (n=47).ConclusionPregnancies in women with pre-existing IHD are high-risk pregnancies. These women have a high risk of ischaemic cardiovascular complications including 2% maternal mortality. The risk of ischaemic complications is especially high among women with atherosclerotic coronary artery disease.
Developmental vulnerabilities in children of chronically ill parents: a population-based linked data study
Authors: Bell Megan F , Bayliss Donna M , Glauert Rebecca , Ohan Jeneva L 
Published: February 2019

BackgroundCurrently, there is mixed evidence regarding the effects on children when a parent is chronically ill. Research has also primarily been conducted with adolescent samples. This study investigated developmental vulnerabilities in young children of parents with chronic illness.MethodsThis study used linked administrative data. The study population included children born in Western Australia during 2003–2004 (n=19 071; mean age 5.5 years). The outcome measure was a score in the bottom 25% on any of the five developmental domains (physical, social, emotional, communicative and cognitive) of the Australian Early Development Census (2009 collection). Parental chronic illnesses were identified from hospital and cancer registry records, during the period from 1 year prior to the child’s birth and until the end of 2009.ResultsHigher odds of developmental vulnerabilities in physical, social, emotional and communication domains were observed for daughters of chronically ill mothers. Sons of chronically ill mothers had increased odds of language and cognitive difficulties. Risk level increased with each additional year of exposure to maternal chronic illness. Results also indicated increased odds of developmental vulnerabilities for children of mothers experiencing multiple compared with single chronic conditions; however, results were not statistically significant (all p>0.05). No association between fathers’ chronic illness and children’s developmental outcomes was found.ConclusionsMaternal chronic illness is associated with an increased risk of poor developmental outcomes for children, particularly daughters. Healthcare services have an important role to play in linking families into appropriate family-centred services to best support the needs of chronically ill mothers.
Evaluation of Pharmacodynamic Responses to Cancer Therapeutic Agents Using DNA Damage Markers
Authors: Wilsker Deborah F. , Barrett Allison M. , Dull Angie B. , Lawrence Scott M. , Hollingshead Melinda G. , Chen Alice , Kummar Shivaani , Parchment Ralph E. , Doroshow James H. , Kinders Robert J. 
Published: February 2019

Abstract

Purpose:
We sought to examine the pharmacodynamic activation of the DNA damage response (DDR) pathway in tumors following anticancer treatment for confirmation of target engagement.

Experimental Design:
We evaluated the time course and spatial activation of 3 protein biomarkers of DNA damage recognition and repair (γH2AX, pS343-Nbs1, and Rad51) simultaneously in a quantitative multiplex immunofluorescence assay (IFA) to assess DDR pathway activation in tumor tissues following exposure to DNA-damaging agents.

Results:
Because of inherent biological variability, baseline DDR biomarker levels were evaluated in a colorectal cancer microarray to establish clinically relevant thresholds for pharmacodynamic activation. Xenograft-bearing mice and clinical colorectal tumor biopsies obtained from subjects exposed to DNA-damaging therapeutic regimens demonstrated marked intratumor heterogeneity in the timing and extent of DDR biomarker activation due, in part, to the cell-cycle dependency of DNA damage biomarker expression.

Conclusions:
We have demonstrated the clinical utility of this DDR multiplex IFA in preclinical models and clinical specimens following exposure to multiple classes of cytotoxic agents, DNA repair protein inhibitors, and molecularly targeted agents, in both homologous recombination–proficient and -deficient contexts. Levels exceeding 4% nuclear area positive (NAP) γH2AX, 4% NAP pS343-Nbs1, and 5% cells with ≥5 Rad51 nuclear foci indicate a DDR activation response to treatment in human colorectal cancer tissue. Determination of effect-level cutoffs allows for robust interpretation of biomarkers with significant interpatient and intratumor heterogeneity; simultaneous assessment of biomarkers induced at different phases of the DDR guards against the risk of false negatives due to an ill-timed biopsy.
Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study
Authors: Arora Pankaj , Kalra Rajat , Callas Peter W. , Alexander Kristine S. , Zakai Neil A. , Wadley Virginia , Arora Garima , Kissela Brett M. , Judd Suzanne E. , Cushman Mary 
Published: February 2019

Objective—
Increased Lp(a) [lipoprotein(a)] is associated with coronary heart disease risk, but links with stroke are less consistent. Blacks have higher Lp(a) levels and stroke incidence than whites but have been underrepresented in studies. We hypothesized that Lp(a) is a risk factor for ischemic stroke and that risk differs by race.

Approach and Results—

REGARDS (Reasons for Geographic and Racial Differences in Stroke) recruited 30 239 black and white US adults aged ≥45 in 2003–2007 to study regional and racial differences in stroke mortality. We measured baseline Lp(a) by immunonephelometric assay in 572 cases of incident ischemic stroke and a 967-person cohort random sample. The hazard ratio of stroke by baseline Lp(a) was calculated using Cox proportional hazards models, stratified by race. Lp(a) was modeled in sex- and race-specific quartiles, given known differences in distributions by race and sex. Interactions were tested by including interaction terms in the proportional hazards models, with
P
<0.10 considered statistically significant. After adjustment for age, sex, and stroke risk factors, being in the fourth versus the first Lp(a) quartile was weakly associated with ischemic stroke overall, hazard ratio, 1.45 (95% CI, 0.96–2.19). In blacks, the hazard ratio was 1.96 (95% CI, 1.10–3.46), whereas in whites HR was 1.14 (95% CI, 0.64–2.04);
P
interaction=0.12. Lp(a) was lower in men than women, but associations with stroke in men and women were similar.

Conclusions—
We confirm that Lp(a) is a risk factor for ischemic stroke. Further research is needed to confirm the role of racial differences of the Lp(a) risk multiplier in ischemic stroke.
Quantifying the Annular Mode Dynamics in an Idealized Atmosphere
Authors: Hassanzadeh Pedram , Kuang Zhiming 
Published: February 2019

Abstract
The linear response function (LRF) of an idealized GCM, the dry dynamical core with Held–Suarez physics, is used to accurately compute how eddy momentum and heat fluxes change in response to the zonal wind and temperature anomalies of the annular mode at the quasi-steady limit. Using these results and knowing the parameterizations of surface friction and thermal radiation in Held–Suarez physics, the contribution of each physical process (meridional and vertical eddy fluxes, surface friction, thermal radiation, and meridional advection) to the annular mode dynamics is quantified. Examining the quasigeostrophic potential vorticity balance, it is shown that the eddy feedback is positive and increases the persistence of the annular mode by a factor of more than 2. Furthermore, how eddy fluxes change in response to only the barotropic component of the annular mode, that is, vertically averaged zonal wind (and no temperature) anomaly, is also calculated similarly. The response of eddy fluxes to the barotropic-only component of the annular mode is found to be drastically different from the response to the full (i.e., barotropic + baroclinic) annular mode anomaly. In the former, the eddy generation is significantly suppressed, leading to a negative eddy feedback that decreases the persistence of the annular mode by nearly a factor of 3. These results suggest that the baroclinic component of the annular mode anomaly, that is, the increased low-level baroclinicity, is essential for the persistence of the annular mode, consistent with the baroclinic mechanism but not the barotropic mechanism proposed in the previous studies.
A Systematic Comparison of Tropical Waves over Northern Africa. Part II: Dynamics and Thermodynamics
Authors: Schlueter Andreas , Fink Andreas H. , Knippertz Peter 
Published: February 2019

AbstractThis study presents the first systematic comparison of the dynamics and thermodynamics associated with all major tropical wave types causing rainfall modulation over northern tropical Africa: the Madden–Julian oscillation (MJO), equatorial Rossby waves (ERs), tropical disturbances (TDs, including African easterly waves), Kelvin waves, mixed Rossby–gravity waves (MRGs), and eastward inertio-gravity waves (EIGs). Reanalysis and radiosonde data were analyzed for the period 1981–2013 based on space–time filtering of outgoing longwave radiation. The identified circulation patterns are largely consistent with theory. The slow modes, MJO and ER, mainly impact precipitable water, whereas the faster TDs, Kelvin waves, and MRGs primarily modulate moisture convergence. Monsoonal inflow intensifies during wet phases of the MJO, ERs, and MRGs, associated with a northward shift of the intertropical discontinuity for MJO and ERs. This study reveals that MRGs over Africa have a distinct dynamical structure that differs significantly from AEWs. During passages of vertically tilted imbalanced wave modes, such as the MJO, TDs, Kelvin waves, and partly MRG waves, increased vertical wind shear and improved conditions for up- and downdrafts facilitate the organization of mesoscale convective systems. The balanced ERs are not tilted, and rainfall is triggered by large-scale moistening and stratiform lifting. The MJO and ERs interact with intraseasonal variations of the Indian monsoon and extratropical Rossby wave trains. The latter causes a trough over the Atlas Mountains associated with a tropical plume and rainfall over the Sahara. The presented results unveil which dynamical processes need to be modeled realistically to represent the coupling between tropical waves and rainfall in northern tropical Africa.
Atmospheric River–Induced Precipitation and Snowpack during the Western United States Cold Season
Authors: Eldardiry Hisham , Mahmood Asif , Chen Xiaodong , Hossain Faisal , Nijssen Bart , Lettenmaier Dennis P. 
Published: February 2019

Abstract
Atmospheric rivers (ARs) are narrow, elongated corridors of high water vapor content transported from tropical and/or extratropical cyclones. We characterize precipitation and snow water equivalent associated with ARs intersecting the western U.S. coast during the cold season (November– March) of water years 1949–2015. For each AR landfalling date, we retrieved the precipitation and relevant hydrometeorological variables from dynamically downscaled atmospheric reanalyses (NCEP–NCAR) using the WRF mesoscale numerical weather prediction model. Landfalling ARs resulted in higher precipitation amounts throughout the domain than did non-AR storms. ARs contributed the most extreme precipitation events during January and February. Daily snow water equivalent (SWE) changes during ARs indicate that high positive net snow accumulation conditions accompany ARs in December, January, and February. We also assess the historical impact of AR storm duration and precipitation frequency by considering the precipitation depth estimated during a 72-h window bounding the AR landfall date. More extreme precipitation amounts are produced by ARs in the South Cascades and Sierra Nevada ranges compared with ARs with landfall farther north. Most AR extreme precipitation events (and lower SWE accumulations) are produced during warm AR dates, especially toward the northern end of our domain. Analysis of ARs during dry and wet years reveals that ARs during wet years are more frequent and produce heavier precipitation and snow accumulation as compared with dry years. Such conditions are evident in drought events that are associated with a reduced frequency of ARs.
Development of a pedagogical framework to analyze the performance of induction machines
Authors: Sridevi R , Kumar C , Suresh P , Ganesan S , Subramanian S , Suresh A 
Published: February 2019

This paper elucidates a procedure for ascertaining the performance of induction generators to disseminate the inevitable role of an induction machine in an alternate energy conversion among undergraduate and postgraduate students. Initially, a circle diagram is constructed for generator mode and motor mode using a drawing tool—AutoCAD from a simplified, energy consumption predetermination test data. Later a set of data is derived and is trained using an innovative, powerful pedagogical tool-radial basis function neural network to predict the performance indices of an induction machine. The proposed technique is compared with the experimental results of a three-phase 5 HP induction machine for various loaded conditions. Further, it provides encouraging results that will help the manufacturers to become more involved in the performance strategies of induction machines. Thus, the noninvasive method avoids the manipulation of an algebraic equation of nth order polynomial equations in predicting the generator performance indices.
ISO 9001 quality management systems in local government institutions in Poland: past, present and future
Authors: Ćwiklicki Marek , Pilch Kamila , Żabiński Michał 
Published: February 2019

The aim of this article is to identify and assess the development of ISO 9001 Quality Management System applications in Polish local government institutions in the years 1999–2015. We conduct our analysis on the basis of a questionnaire survey carried out among local government institutions in 2015 (with 77% rate of response). We prove that the ISO 9001 Quality Management System is dominant in Polish local government institutions and we show that its implementations were geographically concentrated and dependent on the size of the local government institution. Points for practitioners Smaller local government institutions (especially from rural municipalities) require financial support and the proper preparation of employees and training in order to implement the ISO 9001 Quality Management System. The ISO 9001 Quality Management System is the first step in moving towards an integrated management system. The implementation of alternative management improvement solutions decreases interest in implementing the ISO 9001 Quality Management System and obtaining certification.
What are the psychological effects of using synthetic cannabinoids? A systematic review
Authors: Akram Hina , Mokrysz Claire , Curran H Valerie 
Published: February 2019

Background: Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serious psychological effects. Despite government sanctions against their production they continue to be available in ever-increasing varieties over the Internet. The psychological consequences of synthetic cannabinoid use are relatively unknown. Aim: The purpose of this study was to synthesise the available research on the psychological consequences of synthetic cannabinoid use. Method: A literature search of three databases was conducted in February 2018, including the following keywords: Spice, synthetic cannabis, cognition, affect, behaviour, psychosis, depression and anxiety. Results: Seventeen studies involving a variety of participants were eligible for inclusion: one controlled administration study, seven cross-sectional studies, five Internet surveys and four qualitative studies. The controlled administration study showed that, compared to placebo, synthetic cannabinoids acutely affected some aspects of cognitive functioning and subjective psychological ratings. Non-controlled, cross-sectional studies generally showed that synthetic cannabinoid users had lower performance on cognitive tasks and showed elevated symptomatology (e.g. paranoia) compared to both natural cannabis and non-cannabis users. Methodological limitations were noted across different study designs. There is limited research on how doses, frequency or type of synthetic cannabinoid influence outcomes. Conclusions: Acute synthetic cannabinoid use can result in a range of psychological outcomes and, when non-intoxicated, synthetic cannabinoid users appear to differ from natural cannabis and non-users on various affective and cognitive domains. As synthetic cannabinoid use is increasing in at-risk populations there is an urgent need for more and better research to inform users, professionals and policymakers.
Using behavioral economic variables to predict future alcohol use in a crowdsourced sample
Authors: Strickland Justin C , Alcorn Joseph L , Stoops William W 
Published: February 2019

Background: Theoretical perspectives at the intersection of behavioral economics and operant theory have resulted in numerous advances for addiction science. Three mechanisms (i.e. behavioral economic demand [consumption-price relationships], delay discounting [reinforcer devaluation with delay], and proportionate alcohol-related reinforcement [relative reinforcement attributable to alcohol]) are proposed to contribute to problematic alcohol use. Limited research has evaluated the unique contribution of these mechanisms for predicting future alcohol consumption. Aim: The purpose of this study was to evaluate the predictive relationship between these mechanisms and self-reported alcohol use frequency, quantity, and severity. Methods: Participants ( n=223) sampled from the crowdsourcing website Amazon Mechanical Turk completed a survey containing behavioral economic measures. Weekly reports of daily alcohol use were then collected for 18 weeks. Unadjusted and adjusted models determined the association between behavioral economic variables and alcohol use. Results/outcomes: Behavioral economic measures were associated with alcohol and soda use at baseline in a stimulus-selective manner (e.g. alcohol demand associated with alcohol, but not soda, variables). Predictive models adjusted for Alcohol Use Disorder Identification Test scores indicated that increased proportionate alcohol-related reinforcement and behavioral economic demand were uniquely and incrementally associated with frequency (e.g. adjusted odds ratio (AOR)=5.54 for proportionate alcohol-related reinforcement, p<0.05) and quantity-severity measures (e.g. AOR=7.58 for alcohol demand intensity, p<0.001), respectively. Test-retest reliability was generally acceptable ( rxx=0.42–0.76) with the exception of proportionate alcohol-related reinforcement ( rxx=0.29). Conclusion/interpretation: These findings indicate the unique, predictive, and incremental validity of behavioral economic measures for evaluating future alcohol consumption, supporting their continued use in addiction science research.