bluuebunny/crossref_metadata_2025_split huggingface dataset:
B-58 Post-traumatic Stress Symptoms Are Associated with Worse Neuropsychological Functioning, but not Diffusion Tensor Imaging Findings, in Military Service Members Following Mild Traumatic Brain Injury.
Authors: Lange R , Lippa S , Brickell T , Yeh P , French L 
Published: August 2019

Abstract

Objective
The purpose of this study was to examine neurobehavioral and neurocognitive functioning, and white matter integrity (using Diffusion Tensor Imaging [DTI]), in service members with versus without PTSD following mild traumatic brain injury (MTBI).

Method
Participants were 101 U.S. military service members who had sustained an uncomplicated MTBI (n = 80) or an injury without TBI (i.e., Injured Control [IC], n = 21) prospectively enrolled from the Walter Reed National Military Medical Center (Bethesda, Maryland). Participants completed a battery of neuropsychological tests, as well as DTI of the brain, on average 4-years post-injury. Measures of FA, MD, AD, and RD were generated for 18 regions of interest [ROIs]. Participants in the MTBI group were divided into two sub-groups based on DSM-IV-TR diagnostic criteria for PTSD: MTBI/PTSD-Present (n = 22) and MTBI/PTSD-Absent (n = 58).

Results
The MTBI/PTSD-Present group reported a significantly higher number of postconcussion symptoms, had higher scores on the majority of MMPI-2-RF scales, and had worse scores on the vast majority of cognitive domains (i.e., Attention, Processing Speed, Immediate Memory, Delayed Memory, Executive Functioning, Visuospatial Ability) compared to both the MTBI/PTSD-Absent group (all p’s < .05) and IC/PTSD-Absent group (all p’s < .05). For the DTI variables, there were no significant group differences for all DTI measures in all regions of the brain, with the exception of a handful of measures (i.e., right cingulum–cingulate gyrus, and bilaterally in the corticospinal tract).

Conclusion
These results provide support for a (a) strong relationship between PTSD and poor neurobehavioral and neurocognitive outcome following MTBI, and (b) weak relationship between PTSD and white matter integrity following MTBI.
B-70 The Effect of Bilingualism on Trail Making Test Performance in Traumatic Brain Injury Survivors and Healthy Adults
Authors: Litvin P , Rugh-Fraser R , Lopez-Hernandez W , Knight J , Cervantes R , Bueno A , Arzuyan A , Rico M , Fatoorechi S , Mangassarian SHardy D , Vespa P , Plurad D , Hovda D , Woo E , Fuster J , Budding D , Wright M 
Published: August 2019

Abstract

Objective
Traumatic brain injury (TBI) is associated with a number of cognitive deficits. Language factors also impact neurocognitive performance. We examined the effects of TBI and bilingualism/monolingualism on a test of attention and executive functioning (Trail Making Test; TMT).

Method
The sample (N = 96) consisted of 36 healthy controls (19 bilingual; 17 monolingual), 34 acute TBI participants (12 bilingual; 21 monolingual), and 27 chronic TBI participants (16 bilingual; 11 monolingual). Acute TBI participants were tested 6 months post-injury and chronic TBI participants were tested 12 months or more post-injury. 3X2 ANOVAs were conducted to determine the effect of TBI and bilingualism/monolingualism on TMT part A and B.

Results
Main effects were found between groups (i.e., control and TBI groups) on TMT A, p < .001, ηp² = .17 and TMT B, p < .05, ηp² = .09. Pairwise comparisons revealed a difference only between the control group and the 6-month TBI group, with the latter performing worse. Main effects were found for bilingualism/monolingualism on TMT A, p < .05, ηp² = .04 and TMT B, p < .05, ηp² = .05; monolingual participants performed better than bilingual participants. No interactions emerged.

Conclusion
Relative to monolinguals, bilingual participants demonstrated worse attention and executive functioning performances 6 months post-TBI; however, 12 months post-TBI, the difference was negligible.
B-78 Social Skills Training for Verbal Aggression in Conserved Adults with Traumatic Brain Injury, Schizophrenia, and Schizoaffective Disorder
Authors: Ordoñez C , Tiet Q , Scott S , Lopez C , Kixmiller J , Collins W 
Published: August 2019

Abstract

Objective
This pilot study examined the effectiveness of a social skills training (SST) program aimed to decrease verbal aggressive behavior and increase prosocial skills of conserved adults.

Method
Conserved adults (N = 10) with traumatic brain injury, schizophrenia, and schizoaffective disorder received SST for six weeks, an hour weekly, and they were assessed pre- and post-intervention. The Overt Aggression Scale-Modified for Neurorehabilitation-Extended was used to measure aggressive behaviors. Aggressive behavior to self, objects, and others was rated by facility staff that were not involved in the SST. Acquisition of social skills was rated by facility staff on the number of observed prosocial behavior (self-initiates greeting, responds to greeting, expresses gratitude). Only verbal aggression and prosocial scores were used given SST’s content. A paired samples t-test was conducted to evaluate the pre-post effectiveness and effect sizes.

Results
Aggression improved from M = 2.83 (SD = 3.39) to M = 1.00 (SD = 1.98), an improvement of 1.83, but was not statistically significant (t[8] = 2.28, p = .052; Cohen’s d = .76). 95% confidence interval ranged from -0.02 to 3.67. Prosocial behaviors improved from M = 8.67 (SD = 2.35) to M = 9.83 (SD = 2.41), an improvement of 1.17, but was not statistically significant (t[8] = -1.56, p = .158; Cohen’s d = .52). 95% confidence interval ranged from -2.90 to .56.

Conclusions
Effect sizes showed a decrease in aggression and social skills improvement of the participants. This SST is promising and should be examined with randomized controlled trial studies with larger sample sizes.
C-30 The Relationships Between Phonemic and Semantic Fluency and Sleep Duration in Older Adults
Authors: Do C , Suhr J 
Published: August 2019

Abstract

Objective
Sleep deprivation through experimental sleep restriction negatively impacts performance on fluency measures, with stronger effects for phonemic fluency than semantic fluency. However, the relationship between naturalistic short sleep and fluency performance has not yet been examined in older adults. We compared older adults who reported long and short average sleep duration on semantic and phonemic fluency tasks.

Method
83 community-dwelling adults (M = 68.18 years old, SD = 9.08; 71.1% female) participated in a larger study examining sleep quality and cognition. As part of the large battery of sleep, health, and neuropsychological measures, current analyses focused on phonemic fluency (letters C,F,L) and the Semantic Fluency subtest of the Repeatable Battery for the Assessment of Neuropsychological Status. Sleep duration was based on self-report of the average number of hours they sleep per night. Covariates included age and self-reported levels of arousal at the time of testing. Short ( < 7 hours of sleep) and long (≥ 7 hours of sleep) sleepers did not differ in gender, p = .069, but did in age, p = .007, with short sleepers being older than long sleepers. Short sleepers also reported higher arousal at time of testing, p = .017.

Results
After controlling for age and current arousal, short sleepers had lower phonemic fluency scores than did long sleepers, p = .012. However, there was no difference between short and long sleepers on semantic fluency after accounting for the same covariates, p = .849.

Conclusion
These results replicate and extend previous findings of sleep deprivation impacting phonemic fluency and not semantic fluency, but for older adults in more naturalistic conditions of sleep deprivation.
A-21 Inhibition of Overlearned Verbal Responses and Quantity of Speech Among Age Cohorts
Authors: Smith L , Helphrey J , Sawyer J , Rodriguez D , Rose D , Fierro L , Moore J , Parsons T , Barnett M 
Published: August 2019

Abstract

Objective
Off-topic speech (OTS) has been linked with deficits in executive functioning, and specifically inhibition. OTS research has focused primarily on tangentiality, whereas in this study we focused on quantity of speech. The purpose of this study was to investigate the relationship between inhibition of overlearned responses using a Stroop task and quantity of speech.

Method
A college sample of young adults (n = 63; age 18-28) and healthy, community-dwelling older adults (n = 76; age 60-99) completed the Delis-Kaplan Executive Function Systems (D-KEFS) Color-Word Interference Test and provided a verbal sample in which they recounted a procedural memory and an episodic memory. These samples were transcribed and rated for quantity of speech by three independent judges.

Results
Among all participants, longer time to complete color naming (r = -.21, p = .02) and inhibition (r = -.21, p = .01) was associated with lower quantity of speech on procedural memory. Among young adults, longer time to complete inhibition was associated with lower quantity of speech (r = -.26, p = .04). Among older adults, longer time to complete color naming (r = -.32, p = .005), word reading (r = -.27, p = .02), and inhibition (r = -.35, p = .002) was associated with lower quantity of speech. No relationships were found between performance on Stroop conditions and quantity of speech for episodic memory.

Conclusions
Results suggest that among both age cohorts, difficulty inhibiting overlearned verbal responses is associated with lower quantity of speech regarding a procedural memory but not an episodic memory.
A-34 An Atypical Case of Primary Progressive Aphasia: Implications for Differentiating the Semantic Variant
Authors: Jacobs S , Facchini R , Weiss E , McGinley J , Masur D 
Published: August 2019

Abstract

Objective
Primary progressive aphasia is a neurodegenerative condition consisting of three primary variants. The semantic variant (svPPA) is typically associated with anomia and word-finding issues paired with fluent speech, although other symptoms can arise over time including non-verbal deficits and behavioral changes. A complex case of svPPA with evidence of robust impairment across multiple domains in the presence of notable psychosocial and medical factors is presented.

Method
Sixty-year-old woman with complaints of worsening memory and language changes in the context of marked behavioral disinhibition, deterioration of daily functioning, and indication of delusions was seen for outpatient neuropsychological evaluation. Medical history includes severe depression, anxiety, hypertension, and rheumatic heart disease. CT scan was significant for frontal and temporal atrophy and chronic right cerebellar infarct.

Results
Neuropsychological evaluation revealed uniformly extremely low scores. Presentation was notable for inappropriate behaviors, and expressive and receptive language difficulties. Significant confusion and functional impairment were evident. Her time awareness varied and she at some moments spoke about events from 20-30 years ago as if they were recent. Global language impairment was evident on formal testing and clearly moderated all other performances, including tasks of memory which were impaired. Notable weakness in visual-spatial processing and executive function were also present.

Conclusions
Complex medical and psychosocial history, and atypical decline patterns complicated the diagnosis of a patient with profound progressive expressive language impairment. SvPPA is offered as the diagnosis.
A-68 Yoga Therapy in Pediatric Epilepsy
Authors: Cernokova I , Benoit M , Owen T , Bearden D , Ono K 
Published: August 2019

Abstract

Objective
This pilot study examines the effects of yoga therapy on anxiety, depression symptoms, inattention, and seizure frequency in children diagnosed with Epilepsy.

Data Selection
The sample consisted of 5 participants (4 male, 1 female), ages 7-12 years old, with diagnoses of generalized epilepsy, absence epilepsy, and complex partial epilepsy. Participants all had average cognitive abilities (IQ SS = 100.7; VCI SS = 106.3; PRI SS = 108.3), a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), and clinically significant levels of anxiety and depression. Participants participated in 30-45-minute-long yoga sessions over a 6-week period with 2-3 home sessions each week. Differences in hyperactivity, anxiety, depression, and inattention were measured via parent rating Likert scales (0-poor, 10-best) at 1 month, 3 months, and 6 months. Participants also completed weekly self-report measures to assess anxiety and depression (Revised Children’s Manifest Anxiety, Second Edition (RCMAS-2) and Children’s Depression Inventory, Second Edition (CDI-2)).

Data Synthesis
No significant reliable change differences were found between sessions; however, a downward trend was visible in reduction of anxiety (RCMAS-2; first session M = 16.4, last session M = 9.4) and depression symptoms (CDI-2; first session M = 52.8, last session M = 49.2). Further, parents reported a decrease in anxiety (first session M = 4.8, last session M = 6.4). No seizures were reported during the study.

Conclusions
There is no previous research using pediatric populations and yoga therapy effects on reducing seizure frequency, anxiety, depression, and attention problems. This pilot study showed promising results in reducing anxiety, and depression symptoms. Limitations of study include small sample size and attrition, which are both important to consider when conducting another study.
A-79 Flynn Effect Correction: Accuracy Base Rate for IQ/Ability Level
Authors: Slater L , Daniel M 
Published: August 2019

Abstract

Objective
Flynn Effect (FE) is the observed rise in population psychometric intelligence quotient (IQ) scores over time, approximately three IQ points per decade. Sometimes in forensic evaluations, points are deducted from archival IQ scores to “correct” for FE. This study determined the accuracy of FE correction for three IQ ranges.

Method
Participants were 240 people (age: M = 52.7, SD = 24.4; 149 female) from the WAIS-IV standardization group who took the WAIS-III and WAIS-IV in counterbalanced order with an inter-test interval from 6-163 days. WAIS-IV Full Scale IQ (FSIQ) scores were subtracted from WAIS-III scores and differences were divided into two groups: 1.) > 2 IQ points – when applying FE correction to a WAIS-III score produced a more accurate estimate and 2.) < 1 IQ points – when applying FE correction produced a less accurate estimate. Accuracy base rates were tabulated for three WAIS-III FSIQ groups: below average < 89; average 90-109; and above average groups > 110.

Results
FE correction produced more accurate WAIS-IV FSIQ estimates for 70% of the below average group, 56% of the average group, and 65% of the above average group.

Conclusions
Applying an FE correction provides a more accurate WAIS-IV IQ estimate about half the time for average IQ scores and about two-thirds of the time for above and below average IQ scores. (Standardization data from the WAIS-III Copyright © 1997 NCS Pearson Inc. & WAIS-IV Copyright © 2008 NCS Pearson Inc. Used with permission. All rights reserved.)
SimkaMin: fast and resource frugal de novo comparative metagenomics
Authors: Benoit Gaëtan , Mariadassou Mahendra , Robin Stéphane , Schbath Sophie , Peterlongo Pierre , Lemaitre Claire 
Published: August 2019

Abstract

Motivation
De novo comparative metagenomics is one of the most straightforward ways to analyze large sets of metagenomic data. Latest methods use the fraction of shared k-mers to estimate genomic similarity between read sets. However, those methods, while extremely efficient, are still limited by computational needs for practical usage outside of large computing facilities.

Results
We present SimkaMin, a quick comparative metagenomics tool with low disk and memory footprints, thanks to an efficient data subsampling scheme used to estimate Bray-Curtis and Jaccard dissimilarities. One billion metagenomic reads can be analyzed in &lt;3 min, with tiny memory (1.09 GB) and disk (≈0.3 GB) requirements and without altering the quality of the downstream comparative analyses, making of SimkaMin a tool perfectly tailored for very large-scale metagenomic projects.

Availability and implementation
https://github.com/GATB/simka.

Supplementary information
Supplementary data are available at Bioinformatics online.
Magnetoencephalography imaging of high frequency oscillations strengthens presurgical localization and outcome prediction
Authors: Velmurugan Jayabal , Nagarajan Srikantan S , Mariyappa Narayanan , Mundlamuri Ravindranadh C , Raghavendra Kenchaiah , Bharath Rose Dawn , Saini Jitender , Arivazhagan Arimappamagan , Rajeswaran Jamuna , Mahadevan Anita , Malla Bhaskara Rao , Satishchandra Parthasarathy , Sinha Sanjib 
Published: August 2019

See van Klink and Zijlmans (doi:10.1093/brain/awz321) for a scientific commentary on this article.Velmuruganet al. report that detecting and localizing high‐frequency oscillations (HFOs: 80–200 Hz) with MEG can improve presurgical assessment and postsurgical outcome prediction in epilepsy. Source localization of HFOs identifies an epileptogenic region with accuracy of 75%. When such localized sources are surgically resected, patients have an approximately 80% probability of achieving seizure freedom.
High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China
Authors: Borkenhagen Laura K , Wang Guo-Lin , Simmons Ryan A , Bi Zhen-Qiang , Lu Bing , Wang Xian-Jun , Wang Chuang-Xin , Chen Shan-Hui , Song Shao-Xia , Li Min , Zhao Teng , Wu Meng-Na , Park Lawrence P , Cao Wu-Chun , Ma Mai-Juan , Gray Gregory C 
Published: August 2019

Abstract

Background
China is thought to be a hotspot for zoonotic influenza virus emergence, yet there have been few prospective studies examining the occupational risks of such infections.

Methods
We present the first 2 years of data collected from a 5-year, prospective, cohort study of swine-exposed and -unexposed participants at 6 swine farms in China. We conducted serological and virological surveillance to examine evidence for swine influenza A virus infection in humans.

Results
Of the 658 participants (521 swine-exposed and 137 swine-unexposed), 207 (31.5%) seroconverted against at least 1 swine influenza virus subtype (swine H1N1 or H3N2). Swine-exposed participants’ microneutralization titers, especially those enrolled at confined animal feeding operations (CAFOs), were higher against the swine H1N1 virus than were other participants at 12 and 24 months. Despite elevated titers, among the 187 study subjects for whom we had complete follow-up, participants working at swine CAFOs had significantly greater odds of seroconverting against both the swine H1N1 (odds ratio [OR] 19.16, 95% confidence interval [CI] 3.55–358.65) and swine H3N2 (OR 2.97, 95% CI 1.16–8.01) viruses, compared to unexposed and non-CAFO swine workers with less intense swine exposure.

Conclusions
While some of the observed increased risk against swine viruses may have been explained by exposure to human influenza strains, study data suggest that even with elevated preexisting antibodies, swine-exposed workers were at high risk of infection with enzootic swine influenza A viruses.
A Review of Coccidioidomycosis in California: Exploring the Intersection of Land Use, Population Movement, and Climate Change
Authors: Pearson Dharshani , Ebisu Keita , Wu Xiangmei , Basu Rupa 
Published: August 2019

Abstract
California has seen a surge in coccidioidomycosis (valley fever), a disease spread by the Coccidioides immitis fungus found in soil throughout the state, particularly in the San Joaquin Valley. We reviewed epidemiologic studies in which outbreak and sporadic cases of coccidioidomycosis were examined, and we considered the possible relationship of these cases to environmental conditions, particularly the state’s increasing aridity, drought, and wildfire conditions. Most of the studies we reviewed pertained to cases occupationally acquired in construction, military, archeological, and correctional institutional settings where workers were exposed to dust in C. immitis–endemic areas. A few reviewed outbreaks in the general population related to dust exposure from natural disasters, including an earthquake-associated landslide and a dust storm that carried particles long distances from endemic areas. Although many of California’s coccidioidomycosis outbreaks have been occupationally related, changing demographics and new, immunologically naïve populations in dry, endemic areas could expose the general population to C. immitis spores. Given the high rate of infection among workers who, for the most part, are healthy, the general population, including some elderly and immunocompromised individuals, could face additional risk. With climate-related events like drought and wildfires also increasing in endemic areas, research is needed to address the possible associations between these phenomena and coccidioidomycosis outbreaks.
How Politico-Economic Systems Shape Individuals’ Value of Elderly Care: Evidence From the German Reunification
Authors: Diederich Freya , König Hans-Helmut , Brettschneider Christian 
Published: August 2019

AbstractBackground and ObjectivesPerceptions of how societies should care for the elderly people can differ among countries. This study examines to what extent individuals’ value of informal care is shaped by the politico-economic system in which they grew up and if this value adjusts once an individual lives in a different politico-economic system.Research Design and MethodsWe use data from the German Family Panel and take advantage of the unique setting of the German separation and reunification. Probit models are used to examine the effect of being born in East Germany on individuals’ value of informal care relative to employment at different birth cohorts and survey waves (N = 14,093). Average marginal effects are calculated.ResultsTwenty years after reunification, East Germans who spent their adolescence under communism exhibit a higher value of informal care relative to employment than West Germans who grew up in a western social market economy. Differences in values between East and West Germans do not significantly converge over time.Discussion and ImplicationsIndividuals’ value of informal care is deeply shaped by the politico-economic system in which they grew up. If immigration policies are introduced to increase the care for elderly people, differences in individuals’ cultural perceptions of elderly care should be considered as these will not suddenly adjust.