bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulations of a kilometre-thick Arctic ice shelf consistent with ice grounding observations
Authors: Gasson Edward G. W. , DeConto Robert M. , Pollard David , Clark Chris D. 
Published: April 2018

AbstractRecently obtained geophysical data show sets of parallel erosional features on the Lomonosov Ridge in the central Arctic Basin, indicative of ice grounding in water depths up to 1280 m. These features have been interpreted as being formed by an ice shelf—either restricted to the Amerasian Basin (the “minimum model”) or extending across the entire Arctic Basin. Here, we use a numerical ice sheet-shelf model to explore how such an ice shelf could form. We rule out the “minimum model” and suggest that grounding on the Lomonosov Ridge requires complete Arctic ice shelf cover; this places a minimum estimate on its volume, which would have exceeded that of the modern Greenland Ice Sheet. Buttressing provided by an Arctic ice shelf would have increased volumes of the peripheral terrestrial ice sheets. An Arctic ice shelf could have formed even in the absence of a hypothesised East Siberian Ice Sheet.
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
Authors: Zhang Baozhu , Zhang Zhao , Li Lei , Qin Yan-Ru , Liu Haibo , Jiang Chen , Zeng Ting-Ting , Li Meng-Qing , Xie Dan , Li Yan , Guan Xin-Yuan , Zhu Ying-Hui 
Published: April 2018

AbstractBeta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of IκBα. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p. Functional studies demonstrate that TSPAN15 promotes metastatic capabilities of OSCC cells. We further show that TSPAN15 specifically interacts with BTRC to promote the ubiquitination and proteasomal degradation of p-IκBα, and thereby triggers NF-κB nuclear translocation and subsequent activation of transcription of several metastasis-related genes, including ICAM1, VCAM1, uPA, MMP9, TNFα, and CCL2. Collectively, our findings indicate that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target to OSCC patients.
Autonomous robotic searching and assembly of two-dimensional crystals to build van der Waals superlattices
Authors: Masubuchi Satoru , Morimoto Masataka , Morikawa Sei , Onodera Momoko , Asakawa Yuta , Watanabe Kenji , Taniguchi Takashi , Machida Tomoki 
Published: April 2018

AbstractVan der Waals heterostructures are comprised of stacked atomically thin two-dimensional crystals and serve as novel materials providing unprecedented properties. However, the random natures in positions and shapes of exfoliated two-dimensional crystals have required the repetitive manual tasks of optical microscopy-based searching and mechanical transferring, thereby severely limiting the complexity of heterostructures. To solve the problem, here we develop a robotic system that searches exfoliated two-dimensional crystals and assembles them into superlattices inside the glovebox. The system can autonomously detect 400 monolayer graphene flakes per hour with a small error rate (<7%) and stack four cycles of the designated two-dimensional crystals per hour with few minutes of human intervention for each stack cycle. The system enabled fabrication of the superlattice consisting of 29 alternating layers of the graphene and the hexagonal boron nitride. This capacity provides a scalable approach for prototyping a variety of van der Waals superlattices.
In situ X-ray imaging of defect and molten pool dynamics in laser additive manufacturing
Authors: Leung Chu Lun Alex , Marussi Sebastian , Atwood Robert C. , Towrie Michael , Withers Philip J. , Lee Peter D. 
Published: April 2018

AbstractThe laser–matter interaction and solidification phenomena associated with laser additive manufacturing (LAM) remain unclear, slowing its process development and optimisation. Here, through in situ and operando high-speed synchrotron X-ray imaging, we reveal the underlying physical phenomena during the deposition of the first and second layer melt tracks. We show that the laser-induced gas/vapour jet promotes the formation of melt tracks and denuded zones via spattering (at a velocity of 1 m s−1). We also uncover mechanisms of pore migration by Marangoni-driven flow (recirculating at a velocity of 0.4 m s−1), pore dissolution and dispersion by laser re-melting. We develop a mechanism map for predicting the evolution of melt features, changes in melt track morphology from a continuous hemi-cylindrical track to disconnected beads with decreasing linear energy density and improved molten pool wetting with increasing laser power. Our results clarify aspects of the physics behind LAM, which are critical for its development.
Interactions and scattering of quantum vortices in a polariton fluid
Authors: Dominici Lorenzo , Carretero-González Ricardo , Gianfrate Antonio , Cuevas-Maraver Jesús , Rodrigues Augusto S. , Frantzeskakis Dimitri J. , Lerario Giovanni , Ballarini Dario , De Giorgi Milena , Gigli Giuseppe , Kevrekidis Panayotis G. , Sanvitto Daniele 
Published: April 2018

AbstractQuantum vortices, the quantized version of classical vortices, play a prominent role in superfluid and superconductor phase transitions. However, their exploration at a particle level in open quantum systems has gained considerable attention only recently. Here we study vortex pair interactions in a resonant polariton fluid created in a solid-state microcavity. By tracking the vortices on picosecond time scales, we reveal the role of nonlinearity, as well as of density and phase gradients, in driving their rotational dynamics. Such effects are also responsible for the split of composite spin–vortex molecules into elementary half-vortices, when seeding opposite vorticity between the two spinorial components. Remarkably, we also observe that vortices placed in close proximity experience a pull–push scenario leading to unusual scattering-like events that can be described by a tunable effective potential. Understanding vortex interactions can be useful in quantum hydrodynamics and in the development of vortex-based lattices, gyroscopes, and logic devices.
RETRACTED ARTICLE: Supported black phosphorus nanosheets as hydrogen-evolving photocatalyst achieving 5.4% energy conversion efficiency at 353 K
Authors: Tian Bin , Tian Bining , Smith Bethany , Scott M. C. , Hua Ruinian , Lei Qin , Tian Yue 
Published: April 2018

AbstractSolar-driven water splitting using powdered catalysts is considered as the most economical means for hydrogen generation. However, four-electron-driven oxidation half-reaction showing slow kinetics, accompanying with insufficient light absorption and rapid carrier combination in photocatalysts leads to low solar-to-hydrogen energy conversion efficiency. Here, we report amorphous cobalt phosphide (Co-P)-supported black phosphorus nanosheets employed as photocatalysts can simultaneously address these issues. The nanosheets exhibit robust hydrogen evolution from pure water (pH = 6.8) without bias and hole scavengers, achieving an apparent quantum efficiency of 42.55% at 430 nm and energy conversion efficiency of over 5.4% at 353 K. This photocatalytic activity is attributed to extremely efficient utilization of solar energy (~75% of solar energy) by black phosphorus nanosheets and high-carrier separation efficiency by amorphous Co-P. The hybrid material design realizes efficient solar-to-chemical energy conversion in suspension, demonstrating the potential of black phosphorus-based materials as catalysts for solar hydrogen production.
A fully reconfigurable waveguide Bragg grating for programmable photonic signal processing
Authors: Zhang Weifeng , Yao Jianping 
Published: April 2018

AbstractSince the discovery of the Bragg’s law in 1913, Bragg gratings have become important optical devices and have been extensively used in various systems. In particular, the successful inscription of a Bragg grating in a fiber core has significantly boosted its engineering applications. However, a conventional grating device is usually designed for a particular use, which limits general-purpose applications since its index modulation profile is fixed after fabrication. In this article, we propose to implement a fully reconfigurable grating, which is fast and electrically reconfigurable by field programming. The concept is verified by fabricating an integrated grating on a silicon-on-insulator platform, which is employed as a programmable signal processor to perform multiple signal processing functions including temporal differentiation, microwave time delay, and frequency identification. The availability of ultrafast and reconfigurable gratings opens new avenues for programmable optical signal processing at the speed of light.
Constant strain accumulation rate between major earthquakes on the North Anatolian Fault
Authors: Hussain Ekbal , Wright Tim J. , Walters Richard J. , Bekaert David P. S. , Lloyd Ryan , Hooper Andrew 
Published: April 2018

AbstractEarthquakes are caused by the release of tectonic strain accumulated between events. Recent advances in satellite geodesy mean we can now measure this interseismic strain accumulation with a high degree of accuracy. But it remains unclear how to interpret short-term geodetic observations, measured over decades, when estimating the seismic hazard of faults accumulating strain over centuries. Here, we show that strain accumulation rates calculated from geodetic measurements around a major transform fault are constant for its entire 250-year interseismic period, except in the ~10 years following an earthquake. The shear strain rate history requires a weak fault zone embedded within a strong lower crust with viscosity greater than ~1020 Pa s. The results support the notion that short-term geodetic observations can directly contribute to long-term seismic hazard assessment and suggest that lower-crustal viscosities derived from postseismic studies are not representative of the lower crust at all spatial and temporal scales.
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
Authors: Porto William F. , Irazazabal Luz , Alves Eliane S. F. , Ribeiro Suzana M. , Matos Carolina O. , Pires Állan S. , Fensterseifer Isabel C. M. , Miranda Vivian J. , Haney Evan F. , Humblot Vincent , Torres Marcelo D. T. , Hancock Robert E. W. , Liao Luciano M. , Ladram Ali , Lu Timothy K. , de la Fuente-Nunez Cesar , Franco Octavio L. 
Published: April 2018

AbstractPlants are extensively used in traditional medicine, and several plant antimicrobial peptides have been described as potential alternatives to conventional antibiotics. However, after more than four decades of research no plant antimicrobial peptide is currently used for treating bacterial infections, due to their length, post-translational modifications or high dose requirement for a therapeutic effect . Here we report the design of antimicrobial peptides derived from a guava glycine-rich peptide using a genetic algorithm. This approach yields guavanin peptides, arginine-rich α-helical peptides that possess an unusual hydrophobic counterpart mainly composed of tyrosine residues. Guavanin 2 is characterized as a prototype peptide in terms of structure and activity. Nuclear magnetic resonance analysis indicates that the peptide adopts an α-helical structure in hydrophobic environments. Guavanin 2 is bactericidal at low concentrations, causing membrane disruption and triggering hyperpolarization. This computational approach for the exploration of natural products could be used to design effective peptide antibiotics.
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
Authors: El Kasmi Karim C. , Vue Padade M. , Anderson Aimee L. , Devereaux Michael W. , Ghosh Swati , Balasubramaniyan Natarajan , Fillon Sophie A. , Dahrenmoeller Carola , Allawzi Ayed , Woods Crystal , McKenna Sarah , Wright Clyde J. , Johnson Linda , D’Alessandro Angelo , Reisz Julie A. , Nozik-Grayck Eva , Suchy Frederick J. , Sokol Ronald J. 
Published: April 2018

AbstractIn infants intolerant of enteral feeding because of intestinal disease, parenteral nutrition may be associated with cholestasis, which can progress to end-stage liver disease. Here we show the function of hepatic macrophages and phytosterols in parenteral nutrition-associated cholestasis (PNAC) pathogenesis using a mouse model that recapitulates the human pathophysiology and combines intestinal injury with parenteral nutrition. We combine genetic, molecular, and pharmacological approaches to identify an essential function of hepatic macrophages and IL-1β in PNAC. Pharmacological antagonism of IL-1 signaling or genetic deficiency in CCR2, caspase-1 and caspase-11, or IL-1 receptor (which binds both IL-1α and IL-1β) prevents PNAC in mice. IL-1β increases hepatocyte NF-κB signaling, which interferes with farnesoid X receptor and liver X receptor bonding to respective promoters of canalicular bile and sterol transporter genes (Abcc2,Abcb11, andAbcg5/8), resulting in transcriptional suppression and subsequent cholestasis. Thus, hepatic macrophages, IL-1β, or NF-κB may be targets for restoring bile and sterol transport to treat PNAC.
PCGF5 is required for neural differentiation of embryonic stem cells
Authors: Yao Mingze , Zhou Xueke , Zhou Jiajian , Gong Shixin , Hu Gongcheng , Li Jiao , Huang Kaimeng , Lai Ping , Shi Guang , Hutchins Andrew P. , Sun Hao , Wang Huating , Yao Hongjie 
Published: April 2018

AbstractPolycomb repressive complex 1 (PRC1) is an important regulator of gene expression and development. PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has been sub-classified into six major complexes based on the presence of a PCGF subunit. Here, we report that PCGF5, one of six PCGF paralogs, is an important requirement in the differentiation of mouse embryonic stem cells (mESCs) towards a neural cell fate. Although PCGF5 is not required for mESC self-renewal, its loss blocks mESC neural differentiation by activating the SMAD2/TGF-β signaling pathway. PCGF5 loss-of-function impairs the reduction of H2AK119ub1 and H3K27me3 around neural specific genes and keeps them repressed. Our results suggest that PCGF5 might function as both a repressor for SMAD2/TGF-β signaling pathway and a facilitator for neural differentiation. Together, our findings reveal a critical context-specific function for PCGF5 in directing PRC1 to control cell fate.
Stabilised frequency of extreme positive Indian Ocean Dipole under 1.5 °C warming
Authors: Cai Wenju , Wang Guojian , Gan Bolan , Wu Lixin , Santoso Agus , Lin Xiaopei , Chen Zhaohui , Jia Fan , Yamagata Toshio 
Published: April 2018

AbstractExtreme positive Indian Ocean Dipole (pIOD) affects weather, agriculture, ecosystems, and public health worldwide, particularly when exacerbated by an extreme El Niño. The Paris Agreement aims to limit warming below 2 °C and ideally below 1.5 °C in global mean temperature (GMT), but how extreme pIOD will respond to this target is unclear. Here we show that the frequency increases linearly as the warming proceeds, and doubles at 1.5 °C warming from the pre-industrial level (statistically significant above the 90% confidence level), underscored by a strong intermodel agreement with 11 out of 13 models producing an increase. However, in sharp contrast to a continuous increase in extreme El Niño frequency long after GMT stabilisation, the extreme pIOD frequency peaks as the GMT stabilises. The contrasting response corresponds to a 50% reduction in frequency of an extreme El Niño preceded by an extreme pIOD from that projected under a business-as-usual scenario.
Dissolved organic carbon leaching from plastics stimulates microbial activity in the ocean
Authors: Romera-Castillo Cristina , Pinto Maria , Langer Teresa M. , Álvarez-Salgado Xosé Antón , Herndl Gerhard J. 
Published: April 2018

AbstractApproximately 5.25 trillion plastic pieces are floating at the sea surface. The impact of plastic pollution on the lowest trophic levels of the food web, however, remains unknown. Here we show that plastics release dissolved organic carbon (DOC) into the ambient seawater stimulating the activity of heterotrophic microbes. Our estimates indicate that globally up to 23,600 metric tons of DOC are leaching from marine plastics annually. About 60% of it is available to microbial utilization in less than 5 days. If exposed to solar radiation, however, this DOC becomes less labile. Thus, plastic pollution of marine surface waters likely alters the composition and activity of the base of the marine food webs. It is predicted that plastic waste entering the ocean will increase by a factor of ten within the next decade, resulting in an increase in plastic-derived DOC that might have unaccounted consequences for marine microbes and for the ocean system.
Author Correction: Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia
Authors: Bonneau Manon , Atyame Celestine , Beji Marwa , Justy Fabienne , Cohen-Gonsaud Martin , Sicard Mathieu , Weill Mylène 
Published: April 2018

In the originally published HTML and PDF versions of this Article, gel images in Figures 7c and 8c were not prepared as per the Nature journal policy. These figure panels have now been corrected in both the PDF and HTML versions of the Article.In Fig. 7c, the lane labelled ‘Ha’ was inappropriately duplicated to represent the lane labelled ‘Ich13’. The corrected version of Fig. 7c includes PCR-RFLP on DNA from the Ichkeul 13 line, which had been run on a separate gel. The original unprocessed gel images are provided in Supplementary Figure 1 associated with this correction, with the relevant corresponding bands denoted. A repeat experiment of the PCR-RFLP test is also presented as Supplementary Figure 2.In Fig. 8c, the image was assembled from two separate gels without clear demarcation. The corrected Fig. 8c clearly separates lanes from the two gels, and the original unprocessed gel images are provided in the Supplementary Information associated with this correction.These corrections do not alter the original meaning of the experiments, their results, their interpretation, or the conclusions of the paper. We apologize for any confusion this may have caused to the readers of Nature Communications.
Design principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems
Authors: Fei Chenyi , Cao Yuansheng , Ouyang Qi , Tu Yuhai 
Published: April 2018

AbstractBiological systems need to function accurately in the presence of strong noise and at the same time respond sensitively to subtle external cues. Here we study design principles in biochemical oscillatory circuits to achieve these two seemingly incompatible goals. We show that energy dissipation can enhance phase sensitivity linearly by driving the phase-amplitude coupling and increase timing accuracy by suppressing phase diffusion. Two general design principles in the key underlying reaction loop formed by two antiparallel pathways are found to optimize oscillation performance with a given energy budget: balancing the forward-to-backward flux ratio between the two pathways to reduce phase diffusion and maximizing the net flux of the phase-advancing pathway relative to that of the phase-retreating pathway to enhance phase sensitivity. Experimental evidences consistent with these design principles are found in the circadian clock of cyanobacteria. Future experiments to test the predicted dependence of phase sensitivity on energy dissipation are proposed.
Ultra-thin high-efficiency mid-infrared transmissive Huygens meta-optics
Authors: Zhang Li , Ding Jun , Zheng Hanyu , An Sensong , Lin Hongtao , Zheng Bowen , Du Qingyang , Yin Gufan , Michon Jerome , Zhang Yifei , Fang Zhuoran , Shalaginov Mikhail Y. , Deng Longjiang , Gu Tian , Zhang Hualiang , Hu Juejun 
Published: April 2018

AbstractThe mid-infrared (mid-IR) is a strategically important band for numerous applications ranging from night vision to biochemical sensing. Here we theoretically analyzed and experimentally realized a Huygens metasurface platform capable of fulfilling a diverse cross-section of optical functions in the mid-IR. The meta-optical elements were constructed using high-index chalcogenide films deposited on fluoride substrates: the choices of wide-band transparent materials allow the design to be scaled across a broad infrared spectrum. Capitalizing on a two-component Huygens’ meta-atom design, the meta-optical devices feature an ultra-thin profile (λ0/8 in thickness) and measured optical efficiencies up to 75% in transmissive mode for linearly polarized light, representing major improvements over state-of-the-art. We have also demonstrated mid-IR transmissive meta-lenses with diffraction-limited focusing and imaging performance. The projected size, weight and power advantages, coupled with the manufacturing scalability leveraging standard microfabrication technologies, make the Huygens meta-optical devices promising for next-generation mid-IR system applications.
Synthesis of a molecularly defined single-active site heterogeneous catalyst for selective oxidation of N-heterocycles
Authors: Zhang Yujing , Pang Shaofeng , Wei Zhihong , Jiao Haijun , Dai Xingchao , Wang Hongli , Shi Feng 
Published: April 2018

AbstractGenerally, a homogeneous catalyst exhibits good activity and defined active sites but it is difficult to recycle. Meanwhile, a heterogeneous catalyst can easily be reused but its active site is difficult to reveal. It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via controllable construction of a heterogeneous catalyst containing defined active sites. Here, we report that a molecularly defined, single-active site heterogeneous catalyst has been designed and prepared via the oxidative polymerization of maleimide derivatives. These polymaleimide derivatives can be active catalysts for the selective oxidation of heterocyclic compounds to quinoline and indole via the recycling of –C=O and –C–OH groups, which was confirmed by tracing the reaction with GC-MS using maleimide as the catalyst and by FT-IR analysis with polymaleimide as the catalyst. These results might promote the development of heterogeneous catalysts with molecularly defined single active sites exhibiting a comparable activity to homogeneous catalysts.
Snap evaporation of droplets on smooth topographies
Authors: Wells Gary G. , Ruiz-Gutiérrez Élfego , Le Lirzin Youen , Nourry Anthony , Orme Bethany V. , Pradas Marc , Ledesma-Aguilar Rodrigo 
Published: April 2018

AbstractDroplet evaporation on solid surfaces is important in many applications including printing, micro-patterning and cooling. While seemingly simple, the configuration of evaporating droplets on solids is difficult to predict and control. This is because evaporation typically proceeds as a “stick-slip” sequence—a combination of pinning and de-pinning events dominated by static friction or “pinning”, caused by microscopic surface roughness. Here we show how smooth, pinning-free, solid surfaces of non-planar topography promote a different process called snap evaporation. During snap evaporation a droplet follows a reproducible sequence of configurations, consisting of a quasi-static phase-change controlled by mass diffusion interrupted by out-of-equilibrium snaps. Snaps are triggered by bifurcations of the equilibrium droplet shape mediated by the underlying non-planar solid. Because the evolution of droplets during snap evaporation is controlled by a smooth topography, and not by surface roughness, our ideas can inspire programmable surfaces that manage liquids in heat- and mass-transfer applications.