bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transparent wearable three-dimensional touch by self-generated multiscale structure
Authors: Kim Kyun Kyu , Ha InHo , Won Philip , Seo Deog-Gyu , Cho Kyu-Jin , Ko Seung Hwan 
Published: June 2019

AbstractPressure-sensitive touch panels can measure pressure and location (3D) information simultaneously and provide an intuitive and natural method for expressing one’s intention with a higher level of controllability and interactivity. However, they have been generally realized by a simple combination of pressure and location sensor or a stylus-based interface, which limit their implementation in a wide spectrum of applications. Here, we report a first demonstration (to our knowledge) of a transparent and flexible 3D touch which can sense the 3D information in a single device with the assistance of functionally designed self-generated multiscale structures. The single 3D touch system is demonstrated to draw a complex three-dimensional structure by utilizing the pressure as a third coordinate. Furthermore, rigorous theoretical analysis is carried out to achieve the target pressure performances with successful 3D data acquisition in wireless and wearable conditions, which in turn, paves the way for future wearable devices.
A machine learning approach to predicting psychosis using semantic density and latent content analysis
Authors: Rezaii Neguine , Walker Elaine , Wolff Phillip 
Published: June 2019

AbstractSubtle features in people’s everyday language may harbor the signs of future mental illness. Machine learning offers an approach for the rapid and accurate extraction of these signs. Here we investigate two potential linguistic indicators of psychosis in 40 participants of the North American Prodrome Longitudinal Study. We demonstrate how the linguistic marker of semantic density can be obtained using the mathematical method of vector unpacking, a technique that decomposes the meaning of a sentence into its core ideas. We also demonstrate how the latent semantic content of an individual’s speech can be extracted by contrasting it with the contents of conversations generated on social media, here 30,000 contributors to Reddit. The results revealed that conversion to psychosis is signaled by low semantic density and talk about voices and sounds. When combined, these two variables were able to predict the conversion with 93% accuracy in the training and 90% accuracy in the holdout datasets. The results point to a larger project in which automated analyses of language are used to forecast a broad range of mental disorders well in advance of their emergence.
Universality class of explosive percolation in Barabási-Albert networks
Authors: Habib E Islam MD. , Hassan M. K. 
Published: June 2019

AbstractIn this work, we study explosive percolation (EP) in Barabási-Albert (BA) network, in which nodes are born with degree k = m, for both product rule (PR) and sum rule (SR) of the Achlioptas process. For m = 1 we find that the critical point tc = 1 which is the maximum possible value of the relative link density t; Hence we cannot have access to the other phase like percolation in one dimension. However, for m > 1 we find that tc decreases with increasing m and the critical exponents ν, α, β and γ for m > 1 are found to be independent not only of the value of m but also of PR and SR. It implies that they all belong to the same universality class like EP in the Erdös-Rényi network. Besides, the critical exponents obey the Rushbrooke inequality α + 2β + γ ≥ 2 but always close to equality. PACS numbers: 61.43.Hv, 64.60.Ht, 68.03.Fg, 82.70.Dd.
Plasmofluidic Microlenses for Label-Free Optical Sorting of Exosomes
Authors: Zhu Xiangchao , Cicek Ahmet , Li Yixiang , Yanik Ahmet Ali 
Published: June 2019

AbstractOptical chromatography is a powerful optofluidic technique enabling label-free fractionation of microscopic bioparticles from heterogenous mixtures. However, sophisticated instrumentation requirements for precise alignment of optical scattering and fluidic drag forces is a fundamental shortcoming of this technique. Here, we introduce a subwavelength thick (<200 nm) Optofluidic PlasmonIC (OPtIC) microlens that effortlessly achieves objective-free focusing and self-alignment of opposing optical scattering and fluidic drag forces for selective separation of exosome size bioparticles. Our optofluidic microlens provides a self-collimating mechanism for particle trajectories with a spatial dispersion that is inherently minimized by the optical gradient and radial fluidic drag forces working together to align the particles along the optical axis. We demonstrate that this facile platform facilitates complete separation of small size bioparticles (i.e., exosomes) from a heterogenous mixture through negative depletion and provides a robust selective separation capability for same size nanoparticles based on their differences in chemical composition. Unlike existing optical chromatography techniques that require complicated instrumentation (lasers, objectives and precise alignment stages), our OPtIC microlenses with a foot-print of 4 μm × 4 μm open up the possibility of multiplexed and high-throughput sorting of nanoparticles on a chip using low-cost broadband light sources.
Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development
Authors: Takahashi Sonoko , Ishida Azusa , Kubo Akiharu , Kawasaki Hiroshi , Ochiai Sotaro , Nakayama Manabu , Koseki Haruhiko , Amagai Masayuki , Okada Takaharu 
Published: June 2019

AbstractThe epidermal barrier is thought to protect sensory nerves from overexposure to environmental stimuli, and barrier impairment leads to pathological conditions associated with itch, such as atopic dermatitis (AD). However, it is not known how the epidermal barrier continuously protects nerves for the sensory homeostasis during turnover of the epidermis. Here we show that epidermal nerves are contained underneath keratinocyte tight junctions (TJs) in normal human and mouse skin, but not in human AD samples or mouse models of chronic itch caused by epidermal barrier impairment. By intravital imaging of the mouse skin, we found that epidermal nerve endings were frequently extended and retracted, and occasionally underwent local pruning. Importantly, the epidermal nerve pruning took place rapidly at intersections with newly forming TJs in the normal skin, whereas this process was disturbed during chronic itch development. Furthermore, aberrant Ca2+ increases in epidermal nerves were induced in association with the disturbed pruning. Finally, TRPA1 inhibition suppressed aberrant Ca2+ increases in epidermal nerves and itch. These results suggest that epidermal nerve endings are pruned through interactions with keratinocytes to stay below the TJ barrier, and that disruption of this mechanism may lead to aberrant activation of epidermal nerves and pathological itch.
Multiple seasonality in soil radon time series
Authors: Siino Marianna , Scudero Salvatore , Cannelli Valentina , Piersanti Antonio , D’Alessandro Antonino 
Published: June 2019

AbstractThe dynamics governing the movement of the radon are complex and dependent on many factors. In the present study, we characterise the nature of temporal variations of 2-hourly and daily radon measurements in several monitoring sites of the Italian Radon mOnitoring Network (IRON) in Italy. By means of continuous wavelet transformation, a spectral analysis in time-frequency domain is performed. The results reveal that there are sub-daily, daily and yearly persistent periodicities that are common for all the stations. We observe structural seasonal breaks, that occur at the same frequency but at distinct time. Variations in radon concentration and local temperature are studied in terms of frequency contents and synchronicity. When analysing several long time series together, it is evident that the phase difference at low frequency movements (365-day period) between the radon and local temperature time series is depending on the sites’ location and therefore strongly controlled by local factors. This could at least partially explain the apparently contrasting results available in the literature obtained investigating smaller dataset about the relationships between temperature and radon variations. On the other hand, results show that all radon time series are characterised by marked cycles at 1 and 365-days and less evident cycles at 0.5-day and 180-days. They would be all ascribable to environmental-climatic factors: the short-period cycles to temperature and pressure variations, the long-period cycles also to seasonal rainfall variations.
Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics
Authors: Alderman Sarah L. , Crossley Dane A. , Elsey Ruth M. , Gillis Todd E. 
Published: June 2019

AbstractHypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate morphological and functional changes to the heart that persist into later life stages; however, the molecular bases of these changes remain unknown. We tested if targeted and persistent changes in steady-state protein expression underlie this hypoxic heart phenotype, using isobaric tags for relative and absolute quantitation (iTRAQ) proteomics. Alligator eggs were reared under normoxia or 10% hypoxia, then either sampled (embryo) or returned to normoxia for 2 years (juvenile). Three salient findings emerge from the integrated analysis of the 145 differentially expressed proteins in hypoxia-reared animals: (1) significant protein-protein interaction networks were identified only in up-regulated proteins, indicating that the effects of developmental hypoxia are stimulatory and directed; (2) the up-regulated proteins substantially enriched processes related to protein turnover, cellular organization, and metabolic pathways, supporting increased resource allocation towards building and maintaining a higher functioning heart; and (3) the juvenile cardiac proteome retained many of the signature changes observed in embryonic hearts, supporting long-term reprogramming of cardiac myocytes induced by hypoxia during critical periods of development.
The yeast scavenger decapping enzyme DcpS and its application for in vitro RNA recapping
Authors: Wulf Madalee G. , Buswell John , Chan Siu-Hong , Dai Nan , Marks Katherine , Martin Evan R. , Tzertzinis George , Whipple Joseph M. , Corrêa Ivan R. , Schildkraut Ira 
Published: June 2019

AbstractEukaryotic mRNAs are modified at their 5′ end early during transcription by the addition of N7-methylguanosine (m7G), which forms the “cap” on the first 5′ nucleotide. Identification of the 5′ nucleotide on mRNA is necessary for determination of the Transcription Start Site (TSS). We explored the effect of various reaction conditions on the activity of the yeast scavenger mRNA decapping enzyme DcpS and examined decapping of 30 chemically distinct cap structures varying the state of methylation, sugar, phosphate linkage, and base composition on 25mer RNA oligonucleotides. Contrary to the generally accepted belief that DcpS enzymes only decap short oligonucleotides, we found that the yeast scavenger decapping enzyme decaps RNA transcripts as long as 1400 nucleotides. Further, we validated the application of yDcpS for enriching capped RNA using a strategy of specifically tagging the 5′ end of capped RNA by first decapping and then recapping it with an affinity-tagged guanosine nucleotide.
Kidney Dysfunction Impact on White Matter Hyperintensity Volume in Neurologically Healthy Adults
Authors: Kim Sang Hyuck , Yun Jae Moon , Jeong Su-Min , Kim Shinhye , Yoo Tae Gon , Lee Ji Eun , Lim Jae-Sung , Jeong Han-Yeoung , Nam Ki-Woong , Kwon Hyung-Min , Park Jin-Ho 
Published: June 2019

AbstractThe detrimental outcomes of white matter hyperintensity (WMH) are known to be proportional to WMH volume. This study aimed to evaluate the association between kidney dysfunction and white matter hyperintensity (WMH) volume. A total of 2,203 subjects who underwent brain magnetic resonance imaging (MRI) as part of a screening health check-up was included in this study. WMH was defined as hyperintensity signals without cavity formation in the white matter on fluid-attenuated inversion recovery images. WMH volume was measured quantitatively, and data were normalized by square root transformation prior to analysis. Mean age of the subjects was 56.9 years and mean WMH volume was 2.7 cm3. Mean estimated glomerular filtration rate (eGFR) level was 78.0 ml/min/1.73 m2, and 172 subjects (7.8%) were diagnosed with moderate-to-severe kidney dysfunction (eGFR < 60). Mean Urine albumin-to-creatinine ratio (UACR) was 0.02, and 166 subjects showed significant albuminuria (UACR ≥ 0.03). Multivariate analyses showed that each of UACR, significant albuminuria, and moderate-to-severe kidney dysfunction was significantly associated with increased WMH volume (all p < 0.05). When we considered significant albuminuria and moderate-to-severe kidney dysfunction simultaneously, subjects with both significant albuminuria and moderate-to-severe kidney dysfunction had more than twice the WMH volume as did those in the other groups (all p < 0.05). Kidney dysfunction, defined by albuminuria and eGFR, was independently associated with WMH volume. Risk factors related to WMH and its detrimental outcomes should be strictly modified in subjects with kidney dysfunction, especially in those with both albuminuria and a reduced eGFR.
Immunologic findings precede rapid lupus flare after transient steroid therapy
Authors: Lu Rufei , Guthridge Joel M. , Chen Hua , Bourn Rebecka L. , Kamp Stan , Munroe Melissa E. , Macwana Susan R. , Bean Krista , Sridharan Sudhakar , Merrill Joan T. , James Judith A. 
Published: June 2019

AbstractSystemic lupus erythematosus (SLE) flares elicit progressive organ damage, leading to disability and early mortality. This study evaluated clinical and immunologic factors associated with impending flare in the Biomarkers of Lupus Disease study. Autoantibodies and 32 soluble mediators were measured by multiplex assays, immune pathway activation by gene expression module scores, and immune cell subset frequencies and activation states by flow cytometry. After providing baseline samples, participants received transient steroids to suppress disease and were followed until flare. Flare occurred early (within 60 days of baseline) in 21 participants and late (90–165 days) in 13. At baseline, compared to the late flare group, the early flare group had differential gene expression in monocyte, T cell, interferon, and inflammation modules, as well as significantly higher frequencies of activated (aCD11b+) neutrophils and monocytes, and activated (CD86hi) naïve B cells. Random forest models showed three subgroups of early flare patients, distinguished by greater baseline frequencies of aCD11b+monocytes, or CD86hinaïve B cells, or both. Increases in these cell populations were the most accurate biomarkers for early flare in this study. These results suggest that SLE flares may arise from an overlapping spectrum of lymphoid and myeloid mechanisms in different patients.
CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection
Authors: Alisson-Silva Frederico , Mantuano Natália Rodrigues , Lopes Ana Luiza , Vasconcelos-dos-Santos Andréia , Vale André Macedo , Costa Miriam Maria , Cannon Judy L. , Oliveira Ana Carolina , Todeschini Adriane R. 
Published: June 2019

AbstractCD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of CD43 in the immune response againstTrypanosoma cruzi, the protozoan parasite that causes Chagas’ disease, a potential life-threatening illness endemic in 21 Latin American countries according to the WHO. The acute stage of infection is marked by intense parasitemia and cardiac tissue parasitism, resulting in the recruitment of inflammatory cells and acute damage to the heart tissue. We show here thatCD43−/−mice were more resistant to infection due to increased cytotoxicity of antigen specific CD8+ T cells and reduced inflammatory infiltration in the cardiac tissue, both contributing to lower cardiomyocyte damage. In addition, we demonstrate that the induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. Together, our results show the participation of CD43 in different events involved in the pathogenesis ofT. cruziinfection, contributing to a better overall understanding of the mechanisms underlying the pathogenesis of acute chagasic cardiomyopathy.
Investigation ofleptin receptorrs1137101 G&gt;A polymorphism with cancer risk: evidence from 35936 subjects
Authors: Rong Guoxiang , Tang Weifeng , Wang Yafeng , Qiu Hao , Chen Shuchen 
Published: June 2019

AbstractLeptin receptor (LEPR) signaling may be involved in promoting angiogenesis and proliferation, inhibiting apoptosis and playing a vital role in the progression of carcinogenesis. A number of studies have focused on the association of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G&gt;A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44 case–control studies with 35,936 subjects were included. After combining all eligible studies, we identified null relationship between LEPR gene rs1137101 G&gt;A polymorphism and overall cancer risk [A vs. G: odds ratio (OR ) =  0.97, 95% confidence interval (CI ) =  0.89–1.06, P = 0.547; AA vs. GG: OR  =  0.93, 95% CI  =  0.78–1.13, P = 0.476; AA/GA vs. GG: OR  =  0.99, 95% CI  =  0.91–1.09, P= 0.890 and AA vs. GA/GG: OR  = 0.92, 95% CI  =  0.82–1.04, P= 0.198]. However, in a subgroup analysis, there was an increased susceptibility of oral and oropharyngeal cancer in AA vs. GA/GG genetic model (OR, 1.83; 95% CI, 1.01–3.33; P=0.048). Considering the limited participants were included, the findings might be underpowered. Sensitivity analysis identified that any independent study omitted did not materially influence the pooled ORs and CIs. The results of publication bias detection showed that there was no evidence of bias. In summary, this analysis indicates that no significant association of cancer risk was identified to be correlated with rs1137101 G&gt;A variants, even in stratified analyses.
Diagnostic Precision of Open-Set Versus Closed-Set Word Recognition Testing
Authors: Yu Tzu-Ling J. , Schlauch Robert S. 
Published: June 2019

Purpose
The aim of the study was to examine the precision of forced-choice (closed-set) and open-ended (open-set) word recognition (WR) tasks for identifying a change in hearing.

Method
WR performance for closed-set (4 and 6 choices) and open-set tasks was obtained from 70 listeners with normal hearing. Speech recognition was degraded by presenting monosyllabic words in noise (−8, −4, 0, and 4 signal-to-noise ratios) or processed by a sine wave vocoder (2, 4, 6, and 8 channels).

Results
The 2 degraded speech understanding conditions yielded similarly shaped, monotonically increasing psychometric functions with the closed-set tasks having shallower slopes and higher scores than the open-set task for the same listening condition. Fitted psychometric functions to the average data were the input to a computer simulation conducted to assess the ability of each task to identify a change in hearing. Individual data were also analyzed using 95% confidence intervals for significant changes in scores for words and phonemes. These analyses found the following for the most to least efficient condition: open-set (phoneme), open-set (word), closed-set (6 choices), and closed-set (4 choices).

Conclusions
Closed-set WR testing has distinct advantages for implementation, but its poorer precision for identifying a change than open-set WR testing must be considered.
Reliability of the Language Environment Analysis Recording System in Analyzing French–English Bilingual Speech
Authors: Orena Adriel John , Byers-Heinlein Krista , Polka Linda 
Published: June 2019

Purpose
This study examined the utility of the Language ENvironment Analysis (LENA) recording system for investigating the language input to bilingual infants.

Method
Twenty-one French–English bilingual families with a 10-month-old infant participated in this study. Using the LENA recording system, each family contributed 3 full days of recordings within a 1-month period. A portion of these recordings (945 minutes) were manually transcribed, and the word counts from these transcriptions were compared against the LENA-generated adult word counts.

Results
Data analyses reveal that the LENA algorithms were reliable in counting words in both Canadian English and Canadian French, even when both languages are present in the same recording. While the LENA system tended to underestimate the amount of speech in the recordings, there was a strong correlation between the LENA-generated and human-transcribed adult word counts for each language. Importantly, this relationship holds when accounting for different-gendered and different-accented speech.

Conclusions
The LENA recording system is a reliable tool for estimating word counts, even for bilingual input. Special considerations and limitations for using the LENA recording system in a bilingual population are discussed. These results open up possibilities for investigating caregiver talk to bilingual infants in more detail.
Pseudopemphigoid bei topischer Glaukomtherapie
Authors: Geerling Gerd , Roth Mathias 
Published: June 2019

ZusammenfassungDas Pseudopemphigoid ist eine chronische Erkrankung, die zu einer fortschreitenden Vernarbung der Bindehaut bis hin zur Symblepharonbildung führt. Phänotypisch lässt es sich kaum vom echten Schleimhautpemphigoid mit okulärer Beteiligung unterscheiden. Mögliche Auslöser sind Erkrankungen der Augenoberfläche und/oder deren Therapie. Circa die Hälfte aller betroffenen Patienten sind Glaukompatienten unter entsprechender Therapie mit topischen Antiglaukomatosa. Fehlende Zeichen einer systemischen Erkrankung, ein einseitiger Befund und/oder eine positive Glaukomanamnese können auf ein Pseudopemphigoid hinweisen. Im Rahmen dieser Übersicht sollen die beiden Entitäten gegenübergestellt und das diagnostische sowie therapeutische Vorgehen bei Verdacht auf Pseudopemphigoid unter topischer Glaukomtherapie dargestellt werden.