bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of O6-Methylguanine-DNA Methyltransferase in a Long-Surviving Metastatic Melanoma
Authors: Gatti Alessandro , di Meo Nicola , Stinco Giuseppe , Malagoli Maria , Bonin Serena , Trevisan Giusto 
Published: October 2018

Background: Brain metastases commonly occur in patients with metastatic melanoma and are associated with a poor prognosis. Only a few chemotherapeutic agents have been shown to be potentially active. Resistance to chemotherapy is one of the main limitations to treatment. A key mechanism of resistance is O6-methylguanine-DNA methyltransferase (MGMT). The methylation of its promotor could inhibit the activity of this enzyme; consequently, it is very important to evaluate the methylation status of all available specimens. Case Report: We report the case of a long-surviving patient in whom combination treatment with an alkylating agent inhibiting MGMT, such as temozolomide, was useful in clinical control of the disease.
Risk of Myocardial Infarction in Canadian Patients with Psoriasis: A Retrospective Cohort Study
Authors: Levesque Annie , Lachaine Jean , Bissonnette Robert 
Published: October 2018

Background: Studies have shown that psoriatic patients are at increased risk for myocardial infarction (MI) and stroke. There is a lack of data on MI risk in Canadian psoriatic patients. Objective: To compare MI risk in Canadian psoriatic patients to that in control patients. Methods: This was a retrospective cohort study using Quebec's health insurance database (2005–2010) comparing MI risk in psoriatic patients to that in matched controls. Severe psoriasis was defined as any diagnosed psoriatic patient who used phototherapy or oral or injectable psoriasis treatments. Adjustments were made for several MI risk factors. Results: There were 31,421 patients in the psoriasis population, of which 5,159 had severe psoriasis. The unadjusted MI incidence rate per 1,000 person-years was 4.88 (95% confidence interval [95% CI] 4.50–5.20), 5.58 (95% CI 5.10–6.10), and 5.32 (95% CI 4.40–6.40) for the control and mild and severe psoriasis groups, respectively. After adjustments, the hazard ratio of MI was significantly higher for psoriatic patients than for controls (1.17; 95% CI 1.04–1.31). The hazard ratio was also significantly higher than for controls in the mild psoriasis group (1.18; 95% CI 1.05–1.33) but not in the severe psoriasis group (1.16; 95% CI 0.94–1.42). Conclusion: The relative MI risk is higher for Canadian psoriatic patients than for controls.
Measure of Atopic Dermatitis Disease Severity Using Actigraphy
Authors: Sandoval Laura F. , Huang Karen , O'Neill Jenna L. , Gustafson Cheryl J. , Hix Emily , Harrison Jessica , Clark Adele , Buxton Orfeu M. , Feldman Steven R. 
Published: October 2018

Background: Analyzing adherence to treatment and outcomes in atopic dermatitis is limited by methods to assess continual disease severity. Atopic dermatitis significantly impacts sleep quality, and monitoring sleep through actigraphy may capture disease burden. Purpose: To assess if actigraphy monitors provide continuous measures of atopic dermatitis disease severity and to preliminarily evaluate the impact of a short-course, high-potency topical corticosteroid regimen on sleep quality. Methods: Ten patients with mild to moderate atopic dermatitis applied topical fluocinonide 0.1% cream twice daily for 5 days. Sleep data were captured over 14 days using wrist actigraphy monitors. Investigator Global Assessment (IGA) and secondary measures of disease severity were recorded. Changes in quantity of in-bed time sleep were estimated with random effects models. Results: The mean daily in-bed time, total sleep time, and wake after sleep onset (WASO) were 543.7 minutes (SEM 9.4), 466.0 minutes (SEM 7.7), and 75.0 minutes (SEM 3.4), respectively. WASO, a marker of disrupted sleep, correlated with baseline (ρ = .75) and end of treatment IGA (ρ = .70). Most patients did not have marked changes in sleep. IGA scores declined by a median change of 1 point at days 7 ( p = .02) and 14 ( p = .008). Conclusions: Using actigraphy, atopic dermatitis disease severity positively correlated with sleep disturbances. Actigraphy monitors were well tolerated by this cohort of atopic dermatitis subjects.
Dermatofibrosarcoma Protuberans in Pediatric Patients
Authors: Posso-De Los Rios Claudia J. , Lara-Corrales Irene , Ho Nhung 
Published: October 2018

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue tumor. In children, there are acquired and congenital presentations. Due to clinical similarities with other conditions, diagnosis may be delayed. Objective: To review the clinical characteristics and treatment of DFSP in pediatric patients. Methods: A retrospective chart review was performed from January 2002 to September 2012. Inclusion criteria were patients under 18 years of age with a histopathologic diagnosis of DFSP. Data on demographics, clinical characteristics, treatments, and outcomes were collected. Results: Information was gathered from 17 patients; 9 (53%) were female. Congenital lesions were reported in 7 patients. The mean delay of diagnosis was 5.7 years; the most common anatomic location was the trunk in 8 of 17 (47%) cases. Treatment options included wide local surgery, Mohs surgery, and imatinib mesylate. Conclusion: A detailed medical history and identification of the natural course of common conditions seen in pediatric patients are important to identify less common lesions and to suspect DFSP.
Skin Conditions in Community-Living Older Adults
Authors: Guerra Samantha Gontijo , Vasiliadis Helen-Maria , Préville Michel , Berbiche Djamal 
Published: October 2018

Background: There are considerable gaps in the knowledge of the global epidemiology of skin conditions in the geriatric population. Objective: This study attempted to (1) determine the frequency of skin conditions, (2) evaluate the agreement between two different data sources of information (self-report versus administrative), and (3) document medical care service use for skin conditions in a representative sample of community-dwelling older adults. Methods: A secondary analysis using data from a longitudinal population-based health survey conducted in Quebec (2005–2008) within a sample of 2,811 community-dwelling older adults. Results: Our results highlighted a high prevalence rate of self-reported (13%) and diagnosed skin conditions (21%). Agreement between data sources was low (kappa < 0.20). Most dermatologic-related medical visits were made to dermatologists (almost 60%). Conclusion: The epidemiology of skin conditions in the geriatric population is an underresearched field, despite its important prevalence and relevance as a source of information for assessing the health care needs of older adults.
Normas naturales y funciones biológicas
Authors: Saborido Cristian 
Published: October 2018

RESUMENEn este trabajo abordo el problema de la fundamentación teórica de la noción de normatividad natural desde una perspectiva naturalista. Presento el debate actual sobre las funciones biológicas en filosofía de la biología, en el cual pueden encontrarse algunos intentos de fundamentar las normas naturales a través del concepto de función biológica. Sostengo que el enfoque predominante etiológico-evolutivo no es capaz justificar la adscripción de normas naturales en los sistemas biológicos y propongo que la nueva perspectiva organizacional está en la mejor posición para ofrecer un tratamiento naturalista de la teleología biológica y de la normatividad natural.PALABRAS CLAVENORMATIVIDAD, FUNCIÓN, NATURALISMO, TELEOLOGÍA, MALFUNCIÓN, ORGANIZACIÓNABSTRACTIn this paper I consider the problem of the theoretical grounding of the notion of natural normativity for the naturalistic perspective. I present the current debate on biological functions in philosophy of biology in which there are some attempts to ground natural norms through the notion of biological function. I argue that the mainstream account, i.e. the evolutive-etiological approach, is not able to ground the ascription of natural norms in biological systems and I defend that the new organizational approach is in the best position to offer an adequate naturalistic account for biological teleology and natural normativity.KEYWORDSNORMATIVITY, FUNCTION, NATURALISM, TELEOLOGYGY, MALFUNCTION, ORGANIZATION
El controvertido papel del requisito de la autoconciencia en la evaluación moral del daño de la muerte
Authors: Campos Serena Olga 
Published: October 2018

Resumen¿Podemos afirmar que una muerte indolora supone un daño para el individuo que muere? En este artículo se analiza el criterio más utilizado para responder afirmativamente a la pregunta. Un criterio que insiste en la necesidad de tener un interés por seguir viviendo. En el artículo pregunto si la autoconciencia requerida para la presencia del citado interés puede ser realmente condición necesaria en un análisis adecuado del daño de la muerte.Palabras claveMuerte, animales no humanos, autoconciencia,análisis privacionistaAbstractCan we say that a painless death harms the individual who dies? This paper examines the criterion more frequently used to respond affirmatively to this question. It’s an approach that emphasizesthe need to have an interest in staying alive. Here I ask if the self-awarenessrequired for the presence of such interest may actually be a necessary condition in a proper analysis of the harm of death.KeywordsDeath, non human animals, self-awareness, deprivationist analys
Aristóteles y la melancolía. En torno a Problemata XXX,1
Authors: Peretó Rivas Rubén 
Published: October 2018

RESUMENLa melancolía no era desconocida en el mundo clásico. Al contrario, era un ámbito en el que los hombres melancólicos abundaban. Aristóteles, en el texto de Problemas XXX, 1, introduce una precisión acerca de este tema. Dice: Todos los hombres excepcionales son melancólicos. Esta condición obedece, según el Estagirita, a causa físicas –un exceso de bilis negra- y, por tanto, todos aquellos que tengan este exceso participarán también de la excepcionalidad que está reservada a los grandes personajes. Se trata de una afirmación extraña si tenemos en cuenta otros pasajes aristotélicos y que ha provocado interpretaciones diversas y abundantes comentarios. En este trabajo propongo analizar la cuestión de la melancolía en ese texto aristotélico a partir, en primer lugar, de la ubicación del problema en el mundo clásico, avanzando luego hacia una definición de melancolía según el espíritu del Estagirita y su ubicación dentro del corpus doctrinal para finalizar con una conclusión que propone una interpretación base en algunos conceptos de matriz medieval.PALABRAS CLAVEMelancolía - Genialidad - Aristóteles - Tomás de AquinoABSTRACTMelancholy was not unknown in the classic era. On the contrary, that was a time in which melancholic men were many. Aristotle, in the Problems XXX, 1, introduces a precision about this topic. He says: All the exceptional men are melancholic. This condition obeys, according to the Estageira-born, to physical causes – an excess of black bile - and, therefore, all those who have this excess will take part also of the exceptional nature that is reserved to the eminent figures. That is a strange statement if we bear in mind other Aristotelic passages, and it has raised a wide range of interpretations as well as numerous comments. In this work I analyze the question of melancholy in this text, beginning with the contextualization of the problem in the classic world, advancing then towards a definition of melancholy according to the spirit of the Estageira-born and its place inside his doctrinal corpus, finishing with a conclusion that proposes a basic interpretation in some concepts of medieval inspiration.KEYWORDSMelancholy, genius, Aristotle, Thomas Aqu
Nanoética, un nuevo campo para viejos problemas del riesgo tecnológico
Authors: Linares Salgado Jorge E. 
Published: October 2018

RESUMENLas nanotecnologías constituyen actualmente elsector másinnovador y desafiante en el desarrollo tecnocientífico-industrial. Dado que nuestrastecnociencias no son capaces de crearsistemas que sean tanto o más consistentes, más estables y autosustentables que los sistemas naturales, son necesarias e indispensables la supervisión y la regulación prudencial y precautoria de sus efectos y consecuencias, esperadas e inesperadas, mediante un debate público con amplia participación democrática. La nanoética es una forma de poner en acción una racionalidad colectiva prudencial que, en vistas del alcance omniabarcador de las nanotecnologías, tiene que ser construida a partir de principios éticos de alcance global y debe tener un carácter prospectivo.PALABRAS CLAVENANOTECNOLOGÍA, REGULACIÓN, RIESGO TECNOLÓGICO, NANOÉTICAABSTRACTNowadays nanotechnologies constitute the most innovative and challenging sector in technoscientific-industrial development. Our technosciences aren’t capable of generating equally or more consistent stable and self-sufficient systems than natural systems. Therefore, supervision together with reasonable and precautionary regulation of their effects and consequences -being these expected or unexpected-, in the form of public debate with ample democratic participation proves to be necessary. Nanoethics is a way of starting a reasonable collective rationality movement which, in view of the all-containing span of nanotechnologies, must be constructed from ethic principles that have a global reach and must as well have a prospective character.KEYWORDSNANOTECHNOLOGY, REGULATION, TECHNOLOGICAL RISK, NANOETHICS
El empirismo y la filosofía hoy
Authors: García Juan A. 
Published: October 2018

RESUMENLa tesis es, más bien, que la discusión del empirismo, la solución de ese reto empirista que separa el pensar del ser, forma parte de la altura histórica de la filosofía en el momento presente, es una exigencia suya. Si la filosofía comenzó buscando la unidad del ser, ha proseguido resquebrajándola; en particular distinguiendo el ser creado del increado, y luego distinguiendo el ser natural del personal, las cosas de las personas. Estas distinciones afectan de una manera muy particular a las relaciones entre el ser y el pensar, y a su eventual unidad; éste es, por eso, el tema del empirismo, y de nuestro tiempo.PALABRAS CLAVESEMPIRISMO, SER, PENSARABSTRACTThe argument is that the discussion of empiricism is a requirement of philosophy at the present time, solving that challenge that separates thinking of being. If philosophy began seeking the unity of being, has continued dividing this unity; in particular distinguishing the uncreated and created being, and then distinguishing the natural and the personal being. These distinctions affect a particular the relationship between being and thinking, and his eventual drive way; it is, therefore, the issue of empiricism, and our time.KEY WORDSEMPIRICISM, BEING, THINK
El impacto de Heidegger y Gadamer en la hermenéutica trascendental de Apel
Authors: Scivoletto Gonzalo 
Published: October 2018

RESUMENEl presente trabajo tiene por objetivo reconstruir sistemáticamente la “hermenéutica trascendental” de Karl-Otto Apel. En primer lugar, se describe el desarrollo de la interpretación apeliana de Heidegger, la cual consideramos que puede ser dividida en cuatro momentos. En segundo lugar, se explican los principales puntos de disenso de Apel con la hermenéutica filosófica de Gadamer. A lo largo del trabajo sugerimos, además, posibles caminos teóricos abiertos para la hermenéutica trascendental en tanto programa filosófico de investigación. ABSTRACTThis paper aims to systematically reconstruct "transcendental hermeneutics" of Karl-Otto Apel. Firstly, we describe the development of Heidegger's apelian interpretation, which we consider can be divided into four stages. Secondly, we explain the main points of disagreement of Apel with Gadamer’s philosophical hermeneutics. Throughout the work we suggest further possible theoretical opened paths to transcendental hermeneutics as philosophical research program.
Das Problem der Transzendentalen Zeitbestimmung im Rahmen von Kants Philosophie
Authors: Jiménez Rodríguez Alba 
Published: October 2018

Resumen: El presente artículo constituye un estudio sobre el concepto de determinación trascendental temporal expuesto por Kant en el marco del esquematismo trascendental kantiano en KrV. Con este objeto, se exponen las razones de la preminencia de la definición de esquema como transzendentale Zeitbestimmung, frente a otras asociadas a la interpretación estática del esquematismo y, fundamentalmente, frente aquella donde se presenta como un proceso de subsunción o de aplicación de las categorías a las intuiciones puras, reconstruyendo a su vez el alcance de dicha noción a partir del análisis del estatuto de la determinación temporal en otras obras del corpus kantiano. Abstract: In this paper, I focus on the concept of transcendental time-determination exposed by Kant in relation with the transcendental schematism in KrV. With this aim, I discuss why the definition of "schema" as transzendentale Zeitbestimmung is more relevant than other kinds of definitions: the one derived from a static interpretation of the schematism and the one where the schematism is understood as a process of subsumption or application of categories to pure intuitions. Finally, I reconstruct the role of the schema through an analysis of the time-determination as it is developed in the rest of Kant's corpus.
Pobreza y pasividad: una lectura blanchotiana de la naturaleza humana
Authors: Billi Noelia 
Published: October 2018

RESUMEN En el marco de las concepciones compensatorias de la naturaleza humana, la negatividad asignada a lo humano se «dialectiza». A partir de dicha constatación, señalaremos las dificultades que ello implica en el abordaje de las cuestiones actuales en torno al hombre. Evidenciaremos la importancia de renovar la noción de «ausencia de naturaleza» que circula en cierta línea alemana de problematización de lo humano, de la cual la noción de «pobreza» postulada por Heidegger constituirá el exemplum. Valiéndome de la interpretación de la «pobreza» realizada por M. Blanchot, indicaré la posibilidad de leer la ausencia de naturaleza no en tanto pura negatividad sino como pasividad no dialectizable que afecta al hombre.PALABRAS CLAVE POBREZA, PASIVIDAD, BLANCHOT, HEIDEGGER, ESPOSITOABSTRACT Human negativity is “dialectized” within the framework of the compensatory conceptions of Human Nature. After analysing this point, we will call attention to the difficulties it implies when approaching the contemporary questions around the Human Being. We will demonstrate the importance of renewing the notion of ‘absence of nature’ that circulates in a certain German line of research on the human, of which the notion of ‘poverty’ postulated by Heidegger will constitute the exemplum. Making use of the interpretation of “poverty” made by M. Blanchot, we will indicate the possibility of reading the absence of nature not as pure negativity but as nondialectizable passivity that affects Man.KEYWORDS POVERTY, PASSIVITY, BLANCHOT, HEIDEGGER, ESPOSITO
Encuentros y desencuentros filosóficos y políticos entre Badiou y Rancière
Authors: Colella Leonardo 
Published: October 2018

RESUMENEl objetivo de este artículo es contrastar las posturas filosóficas y políticas de Alain Badiou y Jacques Rancière, y aplicar los resultados de ese análisis al ámbito educativo. Para ello abordamos inicialmente las diferencias entre ambos autores respecto de sus teorías del sujeto, sus relaciones con Platón y sus propuestas ontológicas. A continuación consideramos, en primer lugar, una coincidencia acerca del carácter prescriptivo del concepto de «igualdad», y en segundo lugar, una divergencia respecto del «sujeto» y de las consecuencias disruptivas acontecidas a partir de la declaración igualitaria en la educación. PALABRAS CLAVESABER Y PODER –EDUCACIÓN POR VERDADES –IGUALDAD–SUJETO EDUCATIVO. ABSTRACTThe aim of this paper is to contrast the philosophical and political positions of Alain Badiou and Jacques Rancière, and apply the results of this review to education. For this, we initially regard the differences between the two authors about their theories of the subject, its relations with Plato and their ontological proposals. Next, we considered, firstly, a coincidence about the prescriptive concept of «equality», and secondly, a difference with respect to the «subject» and the disruptive consequences from the equalitarian statement in education. KEYWORDSKNOWLEDGE AND POWER –EDUCATION BY TRUTHS –EQUALITY–SUBJECT OF EDUCATION
Ortega, Spengler y el problema de la técnica
Authors: Atencia José María 
Published: October 2018

RESUMEN:El presente trabajo intenta un acercamiento al enfoque sobre la técnica de dos grandes críticos de la cultura contemporánea. Spengler y Ortega lo fueron y sus meditaciones sobre el significado de la técnica no se detienen en la consideración sobre su importancia económica o su relevancia social sino que se adentran en el sentido y significación antropológica. Por nuestra parte tratamos de poner de manifiesto sus coincidencias, así como sus discrepancias: contemplando la técnica como una función esencial de la vida. Frente a la desconsolada concepción de Spengler, Ortega ofrece una visión “deportiva” de la existencia del hombre más optimista.PALABRAS CLAVE: TÉCNICA, VIDA, HOMBRE, CULTURA, ORTEGA, SPENGLERABSTRACT:This article analyzes the view of technology offered by two of the main critics of the contemporary culture: Spengler and Ortega. Their meditations on the meaning of technology are focused not only on its economic or social relevance, but also on its anthropological meaning. I expose their coincidences and their discrepancies when they see technology as a essential function of life. In contrast with Spengler’s disconsolate view, Ortega offers a more optimistic “sportive” conception of human being.KEYWORDS: TECHNOLOGY, LIFE, HUMAN BEING, CULTURE, ORTEGA, SPENGLER
El modelo merleau-pontyano de cognición encarnada
Authors: Battán Horenstein Ariela 
Published: October 2018

RESUMEN:Este artículo aborda la concepción de la cognición encarnada propuesta por M. Merleau-Pontyen dos momentos de su obra, en el contexto de Fenomenología de la percepción y en el Lo visible y lo invisible. El objetivo del artículo consiste en describir las consecuencias epistemo1 Este trabajo ha sido realizado en el marco del PIP CONICET 114-20110100073, «La posibilidad de fundamentación fenomenológica de la intencionalidad corporal: análisis y descripción de la relación percepción y movimiento», 2012-2014 y del Proyecto de Investigación «Fenomenología del cuerpo y análisis del dolor» (FFI 2013-43240-P). Dirección General de Investigación Científica y Técnica. Ministerio de Economía y Competitividad. España. Director: Dr. Agustín Serrano de Haro. Agradezco los comentarios de la Lic. Paula Diaz Romero y las instancias de discusión de las ideas previas al trabajo que tuvieron lugar en el marco de reuniones del grupo de investigación «Fenomenología de la corporeidad» (SECYT-UNC).estudio de la estrecha relación entre percepción y movimiento permitiría aclarar el modelo de cognición encarnada propuesto por Merleau-Ponty y contribuiría a comprender el rol centrallógicas del giro ontológico operado en la última etapa del pensamiento merleau-pontyano. El del cuerpo en la cognición.PALABRAS CLAVES:FENOMENOLOGÍA-CUERPO-GIRO-ONTOLÓGICO-GIRO EPISTEMOLÓGICOABSTRACT:This article addresses Merleau-Ponty´s conception of embodied cognition in two moments ofhis work, in the context of Phenomenology of Perception and The Visible and the Invisible.The central aim of this article consists in describing the epistemological consequences of theontological turn given by merleau-pontian later thought. The study of the close relationship between perception and movement would shed light on the model of embodied cognition proposedby Merleau-Ponty and could contribute to understand the central role of the body in cognition. KEYWORDSPHENOMENOLOGY-BODY-ONTOLOGICAL TURN-EPISTEMOLOGICAL TURN