bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular remodeling in comorbidities associated with heart failure: a current update
Authors: Appunni Sandeep , Rubens Muni , Ramamoorthy Venkataraghavan , Saxena Anshul , McGranaghan Peter , Khosla Atulya , Doke Mayur , Chaparro Sandra , Jimenez Javier 
Published: October 2024

Abstract
Recent advances in genomics and proteomics have helped in understanding the molecular mechanisms and pathways of comorbidities and heart failure. In this narrative review, we reviewed molecular alterations in common comorbidities associated with heart failure such as obesity, diabetes mellitus, systemic hypertension, pulmonary hypertension, coronary artery disease, hypercholesteremia and lipoprotein abnormalities, chronic kidney disease, and atrial fibrillation. We searched the electronic databases, PubMed, Ovid, EMBASE, Google Scholar, CINAHL, and PhysioNet for articles without time restriction. Although the association between comorbidities and heart failure is already well established, recent studies have explored the molecular pathways in much detail. These molecular pathways demonstrate how novels drugs for heart failure works with respect to the pathways associated with comorbidities. Understanding the altered molecular milieu in heart failure and associated comorbidities could help to develop newer medications and targeted therapies that incorporate these molecular alterations as well as key molecular variations across individuals to improve therapeutic outcomes. The molecular alterations described in this study could be targeted for novel and personalized therapeutic approaches in the future. This knowledge is also critical for developing precision medicine strategies to improve the outcomes for patients living with these conditions.
Trend and teleconnection analysis of temperature extremes in New South Wales, Australia
Authors: Laz Orpita U. , Rahman Ataur , Ouarda Taha B. M. J. 
Published: October 2024

AbstractThis study investigates possible trends and teleconnections in temperature extremes in New South Wales (NSW), Australia. Daily maximum and minimum temperature data covering the period 1971–2021 at 26 stations located in NSW were used. Three indices, which focus on daily maximum temperature, daily minimum temperature, and average daily temperature in terms of Excessive Heat Factor (EHF) were investigated to identify the occurrence of heatwaves (HWs). The study considered HWs of different durations (1-, 5-, and 10-days) in relation to intensity, frequency, duration, and their first occurrence parameters. Finally, the influences of three global climate drivers, namely – the El Niño/Southern Oscillation (ENSO), the Southern Annular Mode (SAM), and the Indian Ocean Dipole (IOD) were investigated with associated heatwave attributes for extended Austral summers. In this study, an increasing trend in both hot days and nights was observed for most of the selected stations within the study area. The increase was more pronounced for the last decade (2011–2021) of the investigated time period. The number, duration and frequency of the heatwaves increased over time considering the EHF criterion, whereas no particular trend was detected in cases of TX90 and TN90. It was also evident that the first occurrence of all the HWs shifted towards the onset of the extended summer while considering the EHF criterion of HWs. The correlations between heatwave attributes and climate drivers depicted that heatwave over NSW was positively influenced by both the IOD and ENSO and negatively correlated with SAM. The findings of this study will be useful in formulating strategies for managing the impacts of extreme temperature events such as bushfires, floods, droughts to the most at-risk regions within NSW.
Development of the celiac disease symptom diary version 2.1© (CDSD 2.1©) patient-reported outcome measure
Authors: Howard Kellee , Adelman Daniel , Ghura Sonal , Acaster Sarah , Clifford Sarah , Kelly Ciaran P. , Martin Susan A. , Meckley Lisa M. , Leffler Daniel A. 
Published: October 2024

Abstract
Purpose
For patients with celiac disease (CeD), the only current management option is adherence to a strict gluten-free diet (GFD); however, many patients on a GFD continue to experience symptoms with a significant impact on quality of life. Potential new treatments for CeD are under development and a validated patient-reported outcome measure is required to evaluate their utility in clinical trials. The purpose of this article is to provide a history of the development of the Celiac Disease Symptom Diary (CDSD) 2.1© for use in clinical trials.

Methods
Qualitative and quantitative studies were conducted from 2010 to 2021, including concept elicitation and cognitive debriefing interviews with adult and adolescent participants with CeD (N = 93) diagnosed via biopsy and/or serology and input from eight interviews with CeD clinical experts. During these studies, different iterations of the CDSD were presented to the US Food and Drug Administration and the European Medicines Agency, and modifications were made in line with their feedback.

Results
These studies ultimately led to the development of CDSD 2.1©, a daily diary which focuses on key symptoms of CeD (abdominal pain, bloating, diarrhea, nausea and tiredness). This patient-reported outcome measure was readily understood by adult and adolescent participants with CeD and content validity was demonstrated in both populations.

Conclusion
CDSD 2.1© is a content-valid patient-reported outcome measure developed in accordance with best practices and regulatory guidance. A thorough exploration of the psychometric properties of CDSD 2.1© for both adult and adolescent participants with CeD is ongoing to support utilization in clinical trials.
Testing the psychometric characteristics of EQ-5D-5L and respiratory bolt-ons using a sample of the Australian population
Authors: Bahrampour Mina , Kochovska Slavica , Currow David C. , Viney Rosalie , Mulhern Brendan 
Published: October 2024

Abstract

Purpose
The EQ-5D has been used to assess health related quality of life (HRQoL) in respiratory conditions. However, the core descriptive system may not be sensitive to all the HRQoL impacts of these conditions. To increase the sensitivity of the descriptive system, two respiratory specific bolt-ons, have been developed. Psychometric assessment of the bolt-ons in comparison to other validated instruments is required to facilitate their use. Therefore, the aim of this study is to test the psychometric characteristics of the EQ-5D-5L + R using a large dataset collected in Australia.

Methods
A cross-sectional online survey was used to recruit adult respondents (≥ 18 years) representative of the Australian population. Descriptive and psychometric analyses were used to understand the performance of the EQ-5D-5L and bolt-ons in comparison to other validated instruments. The construct validity was estimated using correlations. Known-group validity was tested to determine the sensitivity of the instruments to differences across different severity groups.

Results
Overall 10,033 respondents (52% female) completed the survey, of which 300 had a respiratory condition. There were moderate to high correlation between bolt-ons with EQ-5D-5L and WHODAS. The EQ-5D-5L + bolt-ons slightly reduced the ceiling effect in comparison to the EQ-5D-5L. The effect size was larger for people with respiratory conditions than people who did not have a respiratory condition.

Conclusion
The results show that adding the respiratory bolt-on to the EQ-5D-5L might slightly improve the instruments descriptive sensitivity. The choice of bolt-on may be driven by whether overall problems or limitations are being measured.
Scaffolding Bad Moral Agents
Authors: Jefferson Anneli , Heinrichs Jan-Hendrik , Sifferd Katrina 
Published: October 2024

AbstractRecent work on ecological accounts of moral responsibility and agency have argued for the importance of social environments for moral reasons responsiveness. Moral audiences can scaffold individual agents’ sensitivity to moral reasons and their motivation to act on them, but they can also undermine it. In this paper, we look at two case studies of ‘scaffolding bad’, where moral agency is undermined by social environments: street gangs and online incel communities. In discussing these case studies, we draw both on recent situated cognition literature and on scaffolded responsibility theory. We show that the way individuals are embedded into a specific social environment changes the moral considerations they are sensitive to in systematic ways because of the way these environments scaffold affective and cognitive processes, specifically those that concern the perception and treatment of ingroups and outgroups. We argue that gangs undermine reasons responsiveness to a greater extent than incel communities because gang members are more thoroughly immersed in the gang environment.
Understanding perioperative risk determinants in carotid endarterectomy: the impact of compromised circle of Willis morphology on inter-hemispheric blood flow indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns
Authors: Czinege Zsófia , Sándor Ágnes Dóra , Gyürki Dániel , Varga Andrea , Csípő Tamás , Székely Andrea , Ungvári Zoltán , Banga Péter , Sótonyi Péter , Horváth Tamás 
Published: October 2024

AbstractCarotid artery stenosis (CAS) often requires surgical intervention through carotid endarterectomy (CEA) to prevent stroke. Accurate cerebrovascular risk assessments are crucial in CEA, as poor collateral circulation can lead to insufficient interhemispheric blood flow compensation, resulting in ischemic complications. Therefore, understanding perioperative risk determinants is vital. This study aims to determine the impact of compromised circle of Willis (CoW) morphology on inter-hemispheric blood flow, focusing on indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns. In 80 CAS patients who underwent CEA, preoperative CT angiography for CoW was conducted. Patients were categorized into five subgroups based on their CoW anatomy and three additional groups based on intraoperative internal carotid artery (ICA) stump backflow patterns evaluated by the surgeon. Continuous blood pressure signals, including systolic, diastolic, mean, and pulse pressure values, were recorded during the procedure. The relationship between CoW anatomical variants and the systolic and diastolic segments of the averaged pressure waveforms, particularly diastolic pressure decay, was analyzed. The correlation between CoW anatomy and stump backflow intensity was also examined. Significant variability in ICA stump backflow and pressure values was evident across CoW variants. Patients with compromised CoW morphology exhibited weaker backflow patterns and lower ICA stump pulse pressure values, consistent with impaired interhemispheric blood flow. Notably, ICA stump diastolic pressure decay was consistent across most CoW variant groups, indicating developed collateral circulation in cases with CoW anomalies. Thus, impaired CoW integrity is associated with compromised interhemispheric blood flow indices based on intraoperative ICA stump pulse pressure and backflow patterns during CEA. Integrating intraoperative pulse waveform analysis with preoperative CT angiography provides a more detailed assessment of cerebrovascular risk, guiding the selective use of shunts. This combined approach may improve surgical outcomes and patient safety by identifying patients at increased risk of perioperative neurological events due to CoW anomalies.
Introducing listening as a weak method for advancing sustainability and interdisciplinary scholarship
Authors: Branny Artur , Maurer Megan , Andersson Erik , McPhearson Timon , Raymond Christopher M. , Faehnle Maija , Olafsson Anton Stahl , Gulsrud Natalie Marie 
Published: October 2024

Abstract
There is now widespread recognition of the need for inter/transdisciplinary (I/TD) approaches to solving global problems like climate change and biodiversity. Yet methods for successfully integrating knowledge across disciplines, and between research and practice, are in need of further development, particularly approaches that can ameliorate epistemological and ontological divides. Here we propose a framework for good listening as a ‘weak method’ that can provide guidance and structure to I/TD collaborations, but does not assume the form and goals a given collaboration will take. Synthesising the results of a scoping, interdisciplinary literature review, we highlight four key components of listening—receiving, processing, interpretation, and feedback/response—and provide a set of normative values regarding ‘good listening’ for each. Our goal is to provide a framework that is grounded in detailed scholarly discussions of listening politics and practice, but that is specifically formulated in response to the needs and concerns of I/TD researchers. We then apply our framework to four commonly encountered challenges in sustainability science, drawing on our collective experience in the field to explore how good listening can aid I/TD collaboration in regards to inclusion, group dynamics, format and pace. In doing so, we hope to inspire those working in sustainability science to approach I/TD collaboration in a new way and provide a tool for facilitating caring and transformational approaches to solving the world’s most pressing sustainability crises.
Spherical Shepard-Bernoulli operator
Authors: Cătinaş Teodora , Malina Andra 
Published: October 2024

Abstract
We consider the problem of interpolating large sets of scattered data on the sphere using Shepard-Bernoulli operators constructed based on two types of basis functions. We study the interpolation properties and the approximation errors of the methods proposed here. We evaluate the efficiency using several test functions and the practical applicability through two real-data problems.
Unusual conditions for the formation of linear discontinuous deformations triggered by underground mining
Authors: Strzałkowski Piotr , Ścigała Roman 
Published: October 2024

AbstractThe occurrence of linear discontinuous deformations, primarily manifesting as ground steps, is becoming increasingly prevalent in mining and post-mining areas. These deformations present a significant hazard to structures, as there are no effective protective measures currently available. An important aspect of these deformations is that they can occur several decades after mining operations have ceased, making it crucial to understand their causes and conditions of formation. This paper presents a detailed case study of ground step formation that resulted in substantial damage to storage halls. Through comprehensive analyses of geological and mining conditions, combined with rigorous calculations, the study identifies the most likely factors that triggered the deformation. Notably, these factors differ from those commonly cited in the existing literature, providing a novel contribution to the research on this issue. The findings underscore the necessity for continuous monitoring and reevaluation of post-mining areas to mitigate potential risks and develop more effective protective strategies.
Acupuncture ameliorates liver injury induced by platinum treatment through the Notch signaling pathway
Authors: Yu Dongdong , Wang Wenzhe , Du Xueyuan , Teng Yingchun , Chao Liqin , Zhang Huanhuan , Fan Shidong , Wei Xingyu , Zhang Chen 
Published: October 2024

AbstractThis work aims to investigate whether acupuncture can ameliorate liver injury caused by platinum-based therapy and relevant mechanism. The liver indices of patients receiving and not receiving acupuncture were analyzed based on the clinical statistics, and it was found that after acupuncture treatment, the aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and γ-glutamyltranspeptidase of the patients were significantly improved. Then, the animal experiments were conducted for verification. After treatment with cisplatin (DDP) modeling and acupuncture, the HE and Masson staining results of the livers of mice showed that the liver injuries were reduced, and the indexes of platelets, AST and ALT became normal after acupuncture treatment. The gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis indicated that acupuncture may ameliorates liver injury through the Notch signaling pathway. Under the effect of blocker γ-secretase inhibitor (DAPT) for the Notch signaling pathway, the expressions of inflammatory factors and the genes and proteins related to the Notch signaling pathway were all up-regulated, while the alleviation of liver injury by acupuncture was inhibited. These results suggest that acupuncture can ameliorate platinum treatment-induced liver injury through the Notch signaling pathway.
On the Diophantine equations of the form $$\lambda _1U_{n_1} + \lambda _2U_{n_2} +\cdots + \lambda _kU_{n_k} = wp_1^{z_1}p_2^{z_2} \cdots p_s^{z_s}$$
Authors: Goedhart Eva , Ha Brian , McBeath Lily , Velasco Luisa 
Published: October 2024

AbstractIn this paper, we consider the Diophantine equation $$\lambda _1U_{n_1}+\cdots +\lambda _kU_{n_k}=wp_1^{z_1} \ldots p_s^{z_s},$$

λ
1

U

n
1

+
⋯
+

λ
k

U

n
k

=
w

p
1

z
1

…

p
s

z
s

,

where $$\{U_n\}_{n\ge 0}$$

{

U
n

}

n
≥
0

is a fixed non-degenerate linear recurrence sequence of order greater than or equal to 2; w is a fixed non-zero integer; $$p_1,\dots ,p_s$$

p
1

,
⋯
,

p
s

are fixed, distinct prime numbers; $$\lambda _1,\dots ,\lambda _k$$

λ
1

,
⋯
,

λ
k

are strictly positive integers; and $$n_1,\dots ,n_k,z_1,\dots ,z_s$$

n
1

,
⋯
,

n
k

,

z
1

,
⋯
,

z
s

are non-negative integer unknowns. We prove the existence of an effectively computable upper-bound on the solutions $$(n_1,\dots ,n_k,z_1,\dots ,z_s)$$

(

n
1

,
⋯
,

n
k

,

z
1

,
⋯
,

z
s

)

. In our proof, we use lower bounds for linear forms in logarithms, extending the work of Pink and Ziegler (Monatshefte Math 185(1):103–131, 2018), Mazumdar and Rout (Monatshefte Math 189(4):695–714, 2019), Meher and Rout (Lith Math J 57(4):506–520, 2017), and Ziegler (Acta Arith 190:139–169, 2019).
Carbon Storage and Fluxes from Sphagnum Peatlands of the Bogong High Plains, Australia
Authors: Treby Sarah , Gunawardhana Meeruppage , Grover Samantha P P , Carnell Paul E 
Published: October 2024

AbstractAustralian alpine peatlands are critically important ecosystems that deliver a range of valuable services. However, our understanding of these services in Australia, particularly peatland carbon cycling, is lacking. Here, we quantified peat soil carbon (C) and nitrogen (N) concentrations, C:N ratios, and C density in eight Sphagnum-dominated peatlands on the Bogong High Plains, southeastern Australia. Soil C and N concentrations averaged 16.5 ± 13.2% and 0.6 ± 0.4%, respectively. C:N ratios averaged 30.9 ± 20.4, and C density averaged 46.6 ± 20.7 mg C cm− 3. Our findings suggest that (1) peat biogeochemistry is highly variable between sites, even at small spatial scales; and (2) while not a direct focus of the study, peat depths in this area were relatively shallow, ranging from 30 to 60 cm, most likely due to previous disturbance causing peat removal and carbon loss. Additionally, we present preliminary data investigating CO2 and CH4 fluxes at these sites. We recommend that future research includes (1) age dating peat cores to better understand the role of disturbance in rates of peat accumulation and loss; and (2) long-term carbon flux studies at multiple peatland sites.
New emerging market economies and the roles of energy use, financial development and socioeconomic aspects
Authors: Eyuboglu Sinem , Uzar Umut , Alola Andrew Adewale 
Published: October 2024

AbstractIn recent years, emerging market economies have consistently achieved growth rates above the world average. In this study, the nexus among economic growth, energy consumption, industrialization, financial development, trade openness, and urbanization were tested over the period 1995–2019 for selected emerging countries (Colombia, India, Indonesia, Kenya, Malaysia, Mexico and Poland). The main findings of this study are as follows: The results showed that energy consumption, industrialization, and financial development positively affected economic growth for the entire panel. While trade openness negatively affected economic growth, urbanization was statistically insignificant. The Dumitrescu and Hurlin causality test results indicate bidirectional causality between energy consumption and economic growth. Economic growth and energy consumption are the causes of industrialization. Thus, it can be concluded that a low-cost energy supply will help maintain economic performance with incentive policies such as tax deductions and credits provided for producers in the examined countries.
Rural–Urban Divide of COVID-19 Fatalities in India—Investigating the Role of Lifestyle Disorder Diseases
Authors: Basu Parantap , Das Susmita , Dutta Choudhury Arnab , Mazumder Ritwik , Sengupta Mahuya 
Published: October 2024

AbstractUsing data on weekly COVID-19 infections and fatalities at the district level for 19 states and 4 union territories of India, we investigate the determinants of COVID-19 deaths focusing exclusively on the second wave of infections. We include several macroeconomic and structural indicators for districts namely, per capita district domestic product, the degree of urbanization, population density, percentage of aged population, share of agriculture, poverty, among several others. Our findings suggest that fatalities have a clear rural–urban divide. Rural agricultural districts with more poor people have experienced less cases and fatalities. Fatalities are more clustered in prosperous and dense industrial districts. Regions having higher COVID-19 fatalities also have a higher proportion of ageing population with urban life-style disorder related diseases such as obesity, diabetes, and hypertension. Prevalence of respiratory illnesses further aggravates the effects of some of these life-style disorder diseases on COVID-19 fatalities.
An Efficient Framework for Secure Dynamic Skyline Query Processing in the Cloud
Authors: Chen Peng , Xu Baochao , Li Hui , Wang Weiguo , Peng Yanguo , Bhowmick Sourav S. , Chen Xiaofeng , Cui Jiangtao 
Published: October 2024

AbstractThis study introduces an innovative framework named scale for processing dynamic skyline queries securely in cloud environments. Unlike previous approaches that require complex operations on encrypted data, scale simplifies dynamic skyline domination to mere comparisons, significantly improving query efficiency. Through empirical evaluations over four datasets, we show that scale accelerates query processing nearly 1000-fold compared to existing state-of-the-art methods. Specifically, scale shows significant efficiency improvements by simplifying query interactions to a single round between the user and the cloud, which is validated through empirical studies on multiple datasets. Moreover, we introduce two distributed versions of scale, dist-scale-s and dist-scale-e, which further optimize performance by facilitating parallel processing. This adaptation showcases a substantial reduction in response times and computational overhead, underpinning the scalability and effectiveness of our framework in handling large-scale, secure cloud-based queries.