bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting outdated POI relations via web‐derived features
Authors: Chuang Hsiu‐Min , Chang Chia‐Hui , Lee Wang‐Chien 
Published: September 2018

AbstractWith the increasing popularity of mobile devices and wireless networks, location‐based services have become widely adopted by consumers. As business points of interest (POIs) and associated information are subject to change over time, it is critical to ensure the correctness of data with a reasonable cost of data verification. In this article, we propose new machine learning approaches for detecting outdated POI information (e.g., location/address and POI name) via web‐derived features. We represent POI information by <address, name> pairs and formulate the problem of detecting the outdated POI pairs in two forms: a classification problem and a ranking problem. We evaluate the proposed methods using a real‐world dataset crawled from Yellow Pages websites. For POI pairs with a one‐to‐one relationship between addresses and names (Address‐to‐one‐POI), the supervised approaches achieve 95.7% accuracy. For POI pairs with a one‐to‐many relationship between addresses and names (Address‐to‐many‐POIs), the best accuracy is 65.8%. By exploiting the strengths of different classifiers, we improve performance by tri‐training to achieve an accuracy of 72.8%.
The Effects of Core Training on Basketball Athletes’ Antioxidant Capacity
Authors: Soslu Recep , Özer Ömer , Çuvalcioğlu İsmail Can 
Published: September 2018

Core strength is defined as producing or protecting the strength, and putting against a resistance. Exercise can cause free radical formation according to its intensity and duration which increase metabolic processes and oxygen consumption. Oxidative stress, muscle fatigue, muscle damage and its pain because of this increase are related with decreasing physical performance. Purpose of this study was to investigate effects of core training on antioxidant system. Participants of this study were 13 basketball players who accepted to attend voluntarily. Mean heights of participants were 175.73±4.26 and mean weights of them were 63.61±5.48. Group followed 8 weeks core training three times a week and 2 hours for each time. Venous blood samples were taken from participants at the end of first, fourth and eighth week trainings. Samples were analyzed according to Antioxidan(Superoxide Dismutase(SOD), Glutatyon Peroksidaz(Gsh-Px), Catalase(CAT) and Malondialdehyde(MDA) parameters. Data were analyzed with Multivariate ANOVA and bonferroni follow-up tests. Results showed that second and third SOD values were significantly higher than first test SOD value before core training process (F(2)= 7.08, p<0.05). Even increase happened, there were not statistically significant difference on GSH (F(2)= 2.57, p>0.05) and CAT (F(2)= 2.80, p>0.05) values. Moreover, second and third MDA values statistically significant decreased according to MDA first test value (F(2)= 7.43, p<0.05). As a conclusion, core exercises increased oxygen consumption which causes free radical formation. It was determined that detrimental effects of this free radical formation were repressed by increasing SOD activity value and it decreased MDA which is free radical parameters. It is thought that increasing antioxidant level via exercise can effect athletes’ performances positively.
Numerical and Experimental Evaluation of a Dual-Fuel Dry-Low-NOx Micromix Combustor for Industrial Gas Turbine Applications
Authors: Funke Harald H. W. , Beckmann Nils , Keinz Jan , Abanteriba Sylvester 
Published: September 2018

Abstract
The dry-low-NOx (DLN) micromix combustion technology has been developed originally as a low emission alternative for industrial gas turbine combustors fueled with hydrogen. Currently, the ongoing research process targets flexible fuel operation with hydrogen and syngas fuel. The nonpremixed combustion process features jet-in-crossflow-mixing of fuel and oxidizer and combustion through multiple miniaturized flames. The miniaturization of the flames leads to a significant reduction of NOx emissions due to the very short residence time of reactants in the flame. The paper presents the results of a numerical and experimental combustor test campaign. It is conducted as part of an integration study for a dual-fuel (H2 and H2/CO 90/10 vol %) micromix (MMX) combustion chamber prototype for application under full scale, pressurized gas turbine conditions in the auxiliary power unit Honeywell Garrett GTCP 36-300. In the presented experimental studies, the integration-optimized dual-fuel MMX combustor geometry is tested at atmospheric pressure over a range of gas turbine operating conditions with hydrogen and syngas fuel. The experimental investigations are supported by numerical combustion and flow simulations. For validation, the results of experimental exhaust gas analyses are applied. Despite the significantly differing fuel characteristics between pure hydrogen and hydrogen-rich syngas, the evaluated dual-fuel MMX prototype shows a significant low NOx performance and high combustion efficiency. The combustor features an increased energy density that benefits manufacturing complexity and costs.
Impact of federal transfers upon US infant mortality rates: a secondary analysis using a fixed effects regression approach
Authors: McLaughlin Michael , Rank Mark R 
Published: September 2018

ObjectivesIn order to improve health outcomes, the federal government allocates hundreds of billions of annual dollars to individual states in order to further the well-being of its citizens. This study examines the impact of such federal intergovernmental transfers on reducing state-level infant mortality rates.SettingAnnual data are collected from all 50 US states between 2004 and 2013.ParticipantsEntire US population under the age of 1 year between 2004 and 2013.Primary and secondary outcome measuresState-level infant mortality rate, neonatal mortality rate and postneonatal mortality rate.ResultsUsing a fixed effects regression model to control for unmeasurable differences between states, the impact of federal transfers on state-level infant mortality rates is estimated. After controlling for differences across states, increases in per capita federal transfers are significantly associated with lower infant, neonatal and postneonatal mortality rates. Holding all other variables constant, a $200 increase in the amount of federal transfers per capita would save one child’s life for every 10 000 live births.ConclusionsConsiderable debate exists regarding the role of federal transfers in improving the well-being of children and families. These findings indicate that increases in federal transfers are strongly associated with reductions in infant mortality rates. Such benefits should be carefully considered when state officials are deciding whether to accept or reject federal funds.
ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas
Authors: Wang Wenjia , Friedland Scott C , Guo Bing , O’Dell Michael R , Alexander William B , Whitney-Miller Christa L , Agostini-Vulaj Diana , Huber Aaron R , Myers Jason R , Ashton John M , Dunne Richard F , Steiner Laurie A , Hezel Aram F 
Published: September 2018

ObjectiveHere, we evaluate the contribution of AT-rich interaction domain-containing protein 1A (ARID1A), the most frequently mutated member of the SWItch/sucrose non-fermentable (SWI/SNF) complex, in pancreatic homeostasis and pancreatic ductal adenocarcinoma (PDAC) pathogenesis using mouse models.DesignMice with a targeted deletion of Arid1a in the pancreas by itself and in the context of two common genetic alterations in PDAC, Kras and p53, were followed longitudinally. Pancreases were examined and analysed for proliferation, response to injury and tumourigenesis. Cancer cell lines derived from these models were analysed for clonogenic, migratory, invasive and transcriptomic changes.ResultsArid1a deletion in the pancreas results in progressive acinar-to-ductal metaplasia (ADM), loss of acinar mass, diminished acinar regeneration in response to injury and ductal cell expansion. Mutant Kras cooperates with homozygous deletion of Arid1a, leading to intraductal papillary mucinous neoplasm (IPMN). Arid1a loss in the context of mutant Kras and p53 leads to shorter tumour latency, with the resulting tumours being poorly differentiated. Cancer cell lines derived from Arid1a-mutant tumours are more mesenchymal, migratory, invasive and capable of anchorage-independent growth; gene expression analysis showed activation of epithelial-mesenchymal transition (EMT) and stem cell identity pathways that are partially dependent on Arid1a loss for dysregulation.ConclusionsARID1A plays a key role in pancreatic acinar homeostasis and response to injury. Furthermore, ARID1A restrains oncogenic KRAS-driven formation of premalignant proliferative IPMN. Arid1a-deficient PDACs are poorly differentiated and have mesenchymal features conferring migratory/invasive and stem-like properties.
Changes in neuromuscular structure and functions of human colon during ageing are region-dependent
Authors: Broad John , Kung Victor W S , Palmer Alexandra , Elahi Shezan , Karami Azadeh , Darreh-Shori Taher , Ahmed Shafi , Thaha Mohamed Adhnan , Carroll Rebecca , Chin-Aleong Joanne , Martin Joanne E , Saffrey M Jill , Knowles Charles H , Sanger Gareth John 
Published: September 2018

ObjectiveTo determine if human colonic neuromuscular functions decline with increasing age.DesignLooking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (cholinergic/nitrergic) contractions/relaxations in ex vivomuscle strips of human ascending and descending colon, aged 35–91 years (macroscopically normal tissue; 239 patients undergoing cancer resection). Then, to understand mechanisms of change, numbers and phenotype of myenteric neurons (30 306 neurons stained with different markers), densities of intramuscular nerve fibres (51 patients in total) and pathways involved in functional changes were systematically investigated (by immunohistochemistry and use of pharmacological tools) in elderly (≥70 years) and adult (35–60 years) groups.ResultsWith increasing age, EFS was more likely to evoke muscle relaxation in ascending colon instead of contraction (linear regression: n=109, slope 0.49%±0.21%/year, 95% CI), generally uninfluenced by comorbidity or use of medications. Similar changes were absent in descending colon. In the elderly, overall numbers of myenteric and neuronal nitric oxide synthase-immunoreactive neurons and intramuscular nerve densities were unchanged in ascending and descending colon, compared with adults. In elderly ascending, not descending, colon numbers of cell bodies exhibiting choline acetyltransferase immunoreactivity increased compared with adults (5.0±0.6 vs 2.4±0.3 neurons/mm myenteric plexus, p=0.04). Cholinergically mediated contractions were smaller in elderly ascending colon compared with adults (2.1±0.4 and 4.1±1.1 g-tension/g-tissue during EFS; n=25/14; p=0.04); there were no changes in nitrergic function or in ability of the muscle to contract/relax. Similar changes were absent in descending colon.ConclusionIn ascending not descending colon, ageing impairs cholinergic function.
Clinical utility of reflex testing using focused next-generation sequencing for management of patients with advanced lung adenocarcinoma
Authors: Miller Tyler E , Yang Michael , Bajor David , Friedman Judah D , Chang Richard Y C , Dowlati Afshin , Willis Joseph E , Sadri Navid 
Published: September 2018

AimsThe growing number of genomically targeted therapies has made genomic testing an important part of the care for patients with non-small cell lung cancer. However, limited tissue availability, cost and long turnaround times can create barriers to efficient genomic testing and subsequent treatment. Effective approaches to reduce these barriers are needed.Methods302 advanced lung adenocarcinomas from consecutive patients seen at University Hospitals Cleveland Medical Center (UHCMC) were tested inhouse using a hybrid DNA/RNA next-generation sequencing (NGS) panel. Sample testing was reflexed from pathology for all stage III or IV tumours. Genomic alterations were tiered according to their clinical relevance and reported with guideline-recommended therapies. Clinical implications of genomic testing results were assessed by manual chart review.ResultsWith a sample cohort consisting of 64% biopsies, 16% excisions/resections and 20% fine needle aspirations, the assay was reliable with a 95% success rate. The average turnaround time from receipt of unstained formalin-fixed paraffin embedded slides to reporting was 4.8±2.1 days, half of the recommended 10 days and similar to single-gene testing. Alterations with Food and Drug Administration-approved or the National Cancer Center Network guideline-recommended targeted therapies were found in 18% of cases. Within this group, 60% of patients went on genomically driven therapies.ConclusionsWe found our reflexed inhouse NGS assay to be reliable, cost-effective and efficient. Incorporation of reflex testing with our NGS assay led to an expansion of successful genomic profiling for all guideline-recommended alterations, and by including an expanded number of alterations within our panel we obtained clinically useful information outside the guidelines without changing cost or efficiency. This approach has enabled UHCMC clinicians to efficiently initiate genomically driven therapies for patients with lung adenocarcinoma.
Sexually transmitted infections during pregnancy and subsequent risk of stillbirth and infant mortality in Kenya: a prospective study
Authors: Warr Alex J , Pintye Jillian , Kinuthia John , Drake Alison L , Unger Jennifer A , McClelland R Scott , Matemo Daniel , Osborn Lusi , John-Stewart Grace 
Published: September 2018

Objectives
We evaluated the relationship of sexually transmitted infections (STIs) and genital infections during pregnancy and subsequent risk for infant mortality and stillbirth.

Methods

This was a nested longitudinal analysis using data from a study of peripartum HIV acquisition in Kenya. In the parent study, HIV-uninfected women were enrolled during pregnancy and followed until 9 months postpartum. For this analysis, women who tested positive for HIV at any point, had a non-singleton pregnancy or a spontaneous abortion <20 weeks were excluded. At enrolment, laboratory methods were used to screen for bacterial vaginosis (BV), vaginal yeast,
Chlamydia trachomatis
(CT),
Neisseria gonorrhoeae
(NG) and
Trichomonas vaginalis
(TV). Syphilis was diagnosed using rapid plasma reagin testing and genital ulcer disease (GUD) identified by clinical examination. Treatment of laboratory-confirmed STIs and syndromic management was provided per Kenyan national guidelines. Predictors of stillbirth and infant mortality were determined using logistic regression and Cox proportional hazards models.

Results
Overall, among 1221 women, 55% had STIs or genital infections detected: vaginal yeast (25%), BV (22%), TV (6%), CT (5%), NG (2%) and syphilis (1%). Among women with STIs/genital infections (n=592), 34% had symptoms. Overall, 19/1221 (2%) women experienced stillbirths. Among 1202 live births, 34 infant deaths occurred (incidence 4.0 deaths per 100 person-years, 95% CI 2.8 to 5.5). After adjustment for maternal age, education and study site, stillbirth was associated with maternal GUD (adjusted OR=9.19, 95% CI1.91 to 44.35, p=0.006). Maternal NG was associated with infant mortality (adjusted HR=3.83, 95% CI1.16 to 12.68, p=0.028); there was some evidence that maternal CT was associated with infant mortality. Stillbirth or infant mortality were not associated with other genital infections.

Conclusions
STIs and genital infections were common, frequently asymptomatic and some associated with stillbirth or infant mortality. Expediting diagnosis and treatment of STIs in pregnancy may improve infant outcomes.
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression
Authors: Gao Xiaomei , Dai Charles , Huang Shengsong , Tang Jingjie , Chen Guoyuan , Li Jianneng , Zhu Ziqi , Zhu Xuyou , Zhou Shuirong , Gao Yuanyuan , Hou Zemin , Fang Zijun , Xu Chengdang , Wang Jianyang , Wu Denglong , Sharifi Nima , Li Zhenfei 
Published: September 2018

Abstract

Purpose:
Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which leads to limited interference strategies for prostate cancer therapy. Here we characterized the clinical relevance, significance, and regulation mechanism of enzyme HSD17B2 in prostate cancer development.

Experimental Design:
HSD17B2 expression was detected with patient specimens and prostate cancer cell lines. Function of HSD17B2 in steroidogenesis, androgen receptor (AR) signaling, and tumor growth was investigated with prostate cancer cell lines and a xenograft model. DNA methylation and mRNA alternative splicing were investigated to unveil the mechanisms of HSD17B2 regulation.

Results:
HSD17B2 expression was reduced as prostate cancer progressed. 17βHSD2 decreased potent androgen production by converting testosterone (T) or dihydrotestosterone (DHT) to each of their upstream precursors. HSD17B2 overexpression suppressed androgen-induced cell proliferation and xenograft growth. Multiple mechanisms were involved in HSD17B2 functional silencing including DNA methylation and mRNA alternative splicing. DNA methylation decreased the HSD17B2 mRNA level. Two new catalytic-deficient isoforms, generated by alternative splicing, bound to wild-type 17βHSD2 and promoted its degradation. Splicing factors SRSF1 and SRSF5 participated in the generation of new isoforms.

Conclusions:
Our findings provide evidence of the clinical relevance, significance, and regulation of HSD17B2 in prostate cancer progression, which might provide new strategies for clinical management by targeting the functional silencing mechanisms of HSD17B2.
See related commentary by Mostaghel, p. 1139
Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association
Authors: Nunes Maria Carmo Pereira , Beaton Andrea , Acquatella Harry , Bern Caryn , Bolger Ann F. , Echeverría Luis E. , Dutra Walderez O. , Gascon Joaquim , Morillo Carlos A. , Oliveira-Filho Jamary , Ribeiro Antonio Luiz Pinho , Marin-Neto Jose Antonio ,   On behalf of the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Published: September 2018

Background:

Chagas disease, resulting from the protozoan
Trypanosoma cruzi
, is an important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally regarded as a tropical disease found only in Central America and South America, Chagas disease now affects at least 300 000 residents of the United States and is growing in prevalence in other traditionally nonendemic areas. Healthcare providers and health systems outside of Latin America need to be equipped to recognize, diagnose, and treat Chagas disease and to prevent further disease transmission.

Methods and Results:

The American Heart Association and the Inter-American Society of Cardiology commissioned this statement to increase global awareness among providers who may encounter patients with Chagas disease outside of traditionally endemic environments. In this document, we summarize the most updated information on diagnosis, screening, and treatment of
T cruzi
infection, focusing primarily on its cardiovascular aspects. This document also provides quick reference tables, highlighting salient considerations for a patient with suspected or confirmed Chagas disease.

Conclusions:
This statement provides a broad summary of current knowledge and practice in the diagnosis and management of Chagas cardiomyopathy. It is our intent that this document will serve to increase the recognition of Chagas cardiomyopathy in low-prevalence areas and to improve care for patients with Chagas heart disease around the world.
Mild Pulmonary Hypertension Is Associated With Increased Mortality: A Systematic Review and Meta‐Analysis
Authors: Kolte Dhaval , Lakshmanan Suvasini , Jankowich Matthew D. , Brittain Evan L. , Maron Bradley A. , Choudhary Gaurav 
Published: September 2018

Background

Recent studies have demonstrated a continuum in clinical risk related to mean pulmonary artery pressure that begins at >19 mm Hg, which is below the traditional threshold used to define pulmonary hypertension (
PH
) of 25 mm Hg. Because of the implications on patient diagnosis and prognosis, the generalizability and validity of these data need further confirmation.

Methods and Results

Databases were searched from inception through January 31, 2018, to identify studies comparing all‐cause mortality between patients with mildly elevated mean pulmonary artery pressure near but <25 mm Hg versus the referent group. The meta‐analysis included 15 nonrandomized studies and 16 482 patients (7451 [45.2%] with measured or calculated mean pulmonary artery pressure of 19–24 mm Hg by right heart catheterization [n=6037] and echocardiography [n=1414] [mild
PH
]). The mean duration of follow‐up was 5.2 years. Compared with the referent group, mild
PH
was associated with an increased risk of mortality (risk ratio, 1.52; 95% confidence interval, 1.32–1.74;
P
<0.001; I
2
=47%). Secondary analysis using risk‐adjusted time‐to‐event estimates showed a similar result (hazard ratio, 1.19; 95% confidence interval, 1.09–1.31;
P
<0.001; I
2
=42%). The findings were consistent between subgroups of right heart catheterization and echocardiography studies (
P
interaction
>0.05). There was evidence of publication bias; however, this did not influence the risk estimate (Duval and Tweedie's trim and fill adjusted risk ratio, 1.34; 95% confidence interval, 1.15–1.56).

Conclusions

The risk of mortality is increased in patients with mild
PH
, defined as measured or calculated mean pulmonary artery pressure >19 mm Hg. These data emphasize a need for diagnosing patients with mild
PH
with consideration to enrollment in
PH
clinical studies investigating pharmacological and nonpharmacological interventions to attenuate clinical risk and improve outcomes.
The Rutherford Atom of Culture
Authors: Hirschfeld Lawrence A. 
Published: September 2018

AbstractIncreasingly, psychologists have shown a healthy interest in cultural variation and a skepticism about assuming that research with North American and Northern European undergraduates provides reliable insight into universal psychological processes. Unfortunately, this reappraisal has not been extended to questioning the notion of culture central to this project. Rather, there is wide acceptance that culture refers to a kind of social form that is entity-like, territorialized, marked by a high degree of shared beliefs and coalescing into patterns of key values that animate a broad range of cultural performances and representations. Ironically, anthropologists and other scholars in cultural studies have overwhelmingly come to reject this view of culture. Arguably, then, the move in psychology to attend to cultural environments has paradoxically further distanced it from the fields most concerned with cultural forms. This essay reviews this state of affairs and offers a proposal how a more nuanced appreciation of cultural life can be articulated with theories and methods familiar and available to psychologists.