bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excretion initiates walking in the cricketGryllus bimaculatus
Authors: Naniwa Keisuke , Sugimoto Yasuhiro , Osuka Koichi , Aonuma Hitoshi 
Published: July 2018

AbstractFeces contain information about the donor and potentially attracts both conspecifics and predators and parasites. The excretory system must be coordinated with other behaviors in insects. We found that crickets start walking forward following excretion of feces. Most intact crickets walked around the experimental arena, stopped at a particular site and raised up their body with a slight backward drift to excrete feces. After the feces dropped on the floor, the animal started walking with a random gait pattern away from the feces, and then changed the gait pattern to a tripod gait. Headless cricket also showed walking following excretion. In more than half of excretion events, headless crickets walked backward before excretion. The posture adopted during excretion was similar to that of intact crickets, and post-excretory forward walking was also observed. The occurrence rate of post-excretory walking was more than that of intact crickets. The gait pattern during forward walking was random and never transitioned to a tripod gait in the headless crickets. In animals whose abdominal nerve cords were cut, in any position, pre- or post-excretion walking was not shown in both intact and headless crickets, although they excreted feces. These results indicate that ascending signals from the terminal abdominal ganglion initiate leg movement through the neuronal circuits within thoracic ganglia, and that descending signals from the brain must regulate leg the motor circuit to express the appropriate walking gait.
Triazole ureas covalently bind to strigolactone receptors and regulate signaling
Authors: Nakamura Hidemitsu , Hirabayashi Kei , Miyakawa Takuya , Kikuzato Ko , Hu Wenqian , Xu Yuqun , Jiang Kai , Takahashi Ikuo , Dohmae Naoshi , Tanokura Masaru , Asami Tadao 
Published: July 2018

AbstractStrigolactones (SLs), a class of plant hormones with multiple functions, mediate plant-plant and plant-microorganism communications in the rhizosphere. In this study, we developed potent strigolactone antagonists, which covalently bind to the strigolactone receptor D14, by preparing an array of triazole urea compounds. Using yeast two-hybrid assays and rice tillering assays, we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors. The LC-MS/MS analysis and X-ray crystallography concluded that KK094 was hydrolyzed by D14, and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14. We also identified KK052 and KK073, whose effects on D14–D53/D14–SLR1 complex formation were opposite due to a trifluoromethyl group on its benzene ring. These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying SL-perception.
Doppler-Based Algorithm for Mapping Cardiac Rotors by Induced Temperature Perturbations
Authors: Malki Guy , Barnea Ofer , Tuller Tamir 
Published: July 2018

AbstractElectrogram-guided ablation for mapping of abnormal atrial activity has become increasingly popular in clinical applications. However, current methods have several limitations, and none have been shown to increase the ablation procedure success rate more than empirical ablation procedures. Here we present a new approach to identify arrhythmogenic sources as targets for ablation. Based on our previous findings that rotor drifting can be characterized by a local temperature gradient within the tissue, this article describes an innovative induced temperature technique which exploits the fact that rotor drifting produces Doppler shifts in the dominant frequency as measured at stationary locations. A mathematical algorithm is detailed to solve the inverse problem, reconstruct the drift trajectory, and predict the rotor origin location. Mathematical modeling and computer simulations demonstrate the feasibility of the new approach for rotors and focal source, two well-known arrhythmogenic sources of irregular conduction. Performance was extensively investigated for different numbers of electrodes and varied SNRs. Random conditions were also taken into account, since the electrodes’ array position and the initial location of the rotor pivot can impact the outcomes. By using temperature perturbation and employing the Doppler algorithm, the rotor drift trajectory and the origin region is shown to be estimated. We consider ways in which this technique can be extended to differentiate between rotors and ectopic activity. Future experimental and clinical validations should lead to potential use in ablation procedures and improve localization capabilities, thus increasing success rates and optimizing arrhythmia management.
Cardiac Spiral Wave Drifting Due to Spatial Temperature Gradients – a Numerical Study
Authors: Malki Guy , Zlochiver Sharon 
Published: July 2018

ABSTRACTCardiac rotors are believed to be a major driver source of persistent atrial fibrillation (AF), and their spatiotemporal characterization is essential for successful ablation procedures. However, electrograms guided ablation have not been proven to have benefit over empirical ablation thus far, and there is a strong need of improving the localization of cardiac arrhythmogenic targets for ablation. A new approach for characterize rotors is proposed that is based on induced spatial temperature gradients (STGs), and investigated by theoretical study using numerical simulations. We hypothesize that such gradients will cause rotor drifting due to induced spatial heterogeneity in excitability, so that rotors could be driven towards the ablating probe. Numerical simulations were conducted in single cell and 2D atrial models using AF remodeled kinetics. STGs were applied either linearly on the entire tissue or as a small local perturbation, and the major ion channel rate constants were adjusted following Arrhenius equation. In the AF-remodeled single cell, recovery time increased exponentially with decreasing temperatures, despite the marginal effect of temperature on the action potential duration. In 2D models, spiral waves drifted with drifting velocity components affected by both temperature gradient direction and the spiral wave rotation direction. Overall, spiral waves drifted towards the colder tissue region associated with global minimum of excitability. A local perturbation with a temperature of T=28°C was found optimal for spiral wave attraction for the studied conditions. This work provides a preliminary proof-of-concept for a potential prospective technique for rotor attraction. We envision that the insights from this study will be utilize in the future in the design of a new methodology for AF characterization and termination during ablation procedures.
Subunit redundancy within the NuRD complex ensures fidelity of ES cell lineage commitment
Authors: Burgold Thomas , Barber Michael , Kloet Susan , Cramard Julie , Gharbi Sarah , Floyd Robin , Kinoshita Masaki , Ralser Meryem , Vermeulen Michiel , Reynolds Nicola , Dietmann Sabine , Hendrich Brian 
Published: July 2018

AbstractMultiprotein chromatin remodelling complexes show remarkable conservation of function amongst metazoans, even though components present in invertebrates are often present as multiple paralogous proteins in vertebrate complexes. In some cases these paralogues specify distinct biochemical and/or functional activities in vertebrate cells. Here we set out to define the biochemical and functional diversity encoded by one such group of proteins within the mammalian Nucleosome Remodelling and Deacetylation (NuRD) complex: Mta1, Mta2 and Mta3. We find that, in contrast to what has been described in somatic cells, MTA proteins are not mutually exclusive within ES cell NuRD and, despite subtle differences in chromatin binding and biochemical interactions, serve largely redundant functions. Nevertheless, ES cells lacking all three MTA proteins represent a complete NuRD null and are viable, allowing us to identify a previously undetected function for NuRD in maintaining differentiation trajectory during early stages of lineage commitment.
Antecedents of pregnant women’s purchase intentions and willingness to pay a premium for organic food
Authors: Konuk Faruk Anıl 
Published: July 2018

PurposeThe purpose of this paper is to examine the effects of health consciousness, environmental concern and customer innovativeness on pregnant women’s purchase intentions and willingness to pay (WTP) a premium for organic food.Design/methodology/approachIn order to collect data, a field study was conducted using administrated questionnaires from a convenience sample of pregnant women in Istanbul, Turkey. A structural equations model was used to test the proposed hypotheses.FindingsResults indicated positive effects of health consciousness, environmental concern and customer innovativeness on both purchase intentions and WTP a premium toward organic food. Specifically, it was found that health consciousness had the greatest influence on purchase intentions and WTP a premium.Originality/valueUnlike previous studies, this research focused on pregnant women and aimed to understand the role of health consciousness, environmental concerned and customer innovativeness on purchase intentions and WTP a premium for organic food.
Leader gender and firm investment in innovation
Authors: Reutzel Christopher R. , Collins Jamie D. , Belsito Carrie A. 
Published: July 2018

PurposeThe purpose of this paper is to examine the influence of business leader gender on the pursuit of innovation opportunities. Extant research suggests that leader gender represents an important characteristic that shapes firm behavior in various ways. The authors build upon this research by relating business leader gender, perceptions of environmental munificence and distributive justice to firm investment in innovation.Design/methodology/approachThis study examines the survey responses of 469 business leaders in India. These individuals were primarily responsible for their firms. Their responses to survey questions were analyzed using ordinary least squares regression.FindingsThe results of this study suggest that female-led firms exhibit less investment in innovation than male-led firms. Results also suggest that female business leaders perceive less environmental munificence as well as distributive justice. Finally, study results suggest that the effect of gender on firm investment in innovation is mediated by perceptions of distributive justice.Originality/valueThis study provides an empirical link between business leader gender and firm investment in innovation. In doing so, it acknowledges and provides insight into the gendered nature of the initiation of innovation processes and leadership. Finally, the finding that business leader perceptions of distributive justice mediate the relationship between business leader gender and investment in innovation extends current understanding of the mechanisms underlying the lower investment in innovation rates exhibited by female-led firms.
Delivering new nuclear projects: a megaprojects perspective
Authors: Saunders Fiona Caroline , Townsend Ellen A. 
Published: July 2018

Purpose
The purpose of this paper is to make recommendations for policy makers, promotors and project managers on how to structure and deliver new nuclear build programmes, by drawing on the megaprojects literature and salutary lessons from previous megaprojects.

Design/methodology/approach
This paper is underpinned by the extant literature and an analysis of public domain data from three proposed new nuclear power plants in the UK. It identifies the main challenges facing new nuclear build projects and subsequently proposes lessons that can be learnt from megaprojects, in order to plan, structure and deliver new nuclear build programmes successfully.

Findings
The paper argues that megaprojects are simultaneously trait-making, rather than trait-taking, possess a temporality and timescale in excess of typical infrastructure projects, suffer from high levels of uncertainty and ambiguity, are organisationally complex, costly and are highly likely to destroy rather than create value. Second, it argues that the challenges facing new nuclear build are not merely technological but also institutional, political and societal in nature. The nature of these challenges is exemplified using three proposed new nuclear build projects in the UK.

Originality/value
This is the first paper to draw on both extant megaproject theory and on an analysis of the public domain data from three proposed new nuclear power plants in the UK. It makes contributions to megaprojects theory and practice, and specifically to nuclear new build projects. Importantly, it proffers recommendations for how new nuclear build programmes around the world might be structured, planned and delivered to minimise the risks of failure.
Sex‐specific patterns of reproductive senescence in a long‐lived reintroduced raptor
Authors: Murgatroyd Megan , Roos Staffan , Evans Richard , Sansom Alex , Whitfield D. Philip , Sexton David , Reid Robin , Grant Justin , Amar Arjun 
Published: July 2018

AbstractFor many species, there is evidence that breeding performance changes as an individual ages. In iteroparous species, breeding performance often increases through early life and is expected to level out or even decline (senesce) later in life. An individual's sex and conditions experienced in early life may also affect breeding performance and how this changes with age.Long‐term monitoring of individuals from reintroduced populations can provide unique opportunities to explore age‐related trends in breeding performance that might otherwise be logistically challenging.We used a unique dataset from a reintroduced population of white‐tailed eaglesHaliaeetus albicillain Scotland, which has been intensively monitored since their initial reintroduction in 1975, to study age‐ and sex‐specific trends in two measures of breeding performance. This monitoring provided data on the breeding performance of known individuals ranging in age from 3 to 26 years. We also explored changes in breeding performance in relation to early life experience (i.e., whether they were released or fledged in the wild).Breeding performance increased with age in early life in a similar manner for both sexes. We found stronger evidence for senescence in breeding performance in males than females. However, late‐life female breeding success was associated with early life experience, while male senescent trends were not apparently impacted by conditions experienced during early life.Sexual differences in senescence mean that older males are less likely to breed successfully compared to older females, and this may influence females’ mate changes later in life. This difference may suggest a linked sexual difference in survival rates or the possibility of proactive partner change by females in later life in this typically monogamous biparental species.
Academic Factors Related to Student Achievement in a Capstone Food Chemistry Course
Authors: Shoulders Catherine W. , Johnson Donald M. , O'Bryan Corliss A. , Crandall Philip G. 
Published: July 2018

AbstractThe 1st step in successfully intervening with students who may fail a course is to identify them as early as possible in the semester. The objective of this study was to create a model to predict student performance in FDSC 4304, the required capstone Food Chemistry class, using academic performance in prerequisite courses as potential predictors. We analyzed data for 116 undergraduates who completed Food Chemistry (FDSC 4304) between 2008 and 2015. Data included semester of enrollment and grade earned in FDSC 4304; transfer status; grades in prerequisite classes in science, math, and statistics courses and an introductory Food Science course, FDSC 1103; and the students’ university GPA at the time of enrollment in FDSC 4304. Cumulative GPA had the strongest significant (P < 0.001) positive correlation with FDSC 4304 grade (r = 0.64), followed by grade in statistics GPA (r = 0.52), FDSC 1103 grade (r = 0.45), pre‐requisite chemistry GPA (r = 0.44), and biology GPA (r = 0.42). When using partial correlations to control for cumulative GPA, only grades in FDSC 1103 (completed by 62.9% of students) were significantly correlated with grades in FDSC 4304. Linear regression indicated cumulative GPA and FDSC 1103 grades explained 35.5% of the variance in FDSC 4304 grades. When cumulative GPA (available for 91.6% of students) alone was regressed on FDSC 4304, it explained 40.6% of the variance for the larger group. Lower cumulative GPAs and FDSC 1103 grades are suggestive but not determinative of potential student struggles in FDSC 4304. Instructors should use cumulative GPAs and introductory food science course grades (either alone or in combination) with actual early course performance measures to identify students in need of additional help.
Rectal cancer staging: An up‐to‐date pictorial review
Authors: Crimì Filippo , Lacognata Carmelo , Cecchin Diego , Zucchetta Pietro , Pomerri Fabio 
Published: July 2018

SummaryColorectal cancer is the third most common malignancy worldwide, and rectal cancer (RC) accounts for 29% of all cases. Local staging of RC is crucial for the purposes of addressing patients appropriately to surgery alone or to preoperative chemoradiotherapy (pCRT) followed by total mesorectal excision (TME). Combined pCRT and TME may negatively affect rectal function, so rectum‐sparing approaches such as transanal local excision have been proposed as an alternative to TME for patients showing a major or complete clinical response on restaging after pCRT. Magnetic resonance imaging (MRI) has a fundamental role in the local staging and restaging of RC, with or without positron emission tomography (PET). PET/MRI enables a multiplanar high‐resolution morphological study of the pelvis, providing important information on cell density and metabolic activity with diffusion‐weighted imaging (DWI) and 18F fluorodeoxyglucose uptake respectively. This article offers a pictorial review of the MRI anatomy of the ano‐rectal region and an update on local RC staging with a hybrid 18F‐FDG PET/MRI scan.
Daily intra‐abdominal pressure, Sequential Organ Failure Score and fluid balance predict duration of mechanical ventilation
Authors: Iyer Dushyant , Hunt Leanne , Frost Steven A. , Aneman Anders 
Published: July 2018

BackgroundElevated intra‐abdominal pressure (IAP) is a common occurrence in mechanically ventilated patients in the intensive care unit (ICU). This study was undertaken to determine the relationship between IAP, pulmonary compliance and the duration of mechanical ventilation.MethodsA prospective study of 220 consecutively enrolled mechanically ventilated patients admitted to a mixed surgical‐medical ICU in a tertiary referral hospital. The IAP was measured at least twice daily, benchmarked against consensus guidelines. Dynamic pulmonary compliance was calculated together with admission Acute Physiology and Chronic Health Evaluation (APACHE III) score and daily Sequential Organ Failure Assessment (SOFA) score.ResultsNo relationship between highest IAP for the day and pulmonary compliance (P = 0.61) was found. For each 5 mm Hg increase in IAP, the risk of remaining intubated increased 19% (HR = 1.19, 95% CI: 0.98‐1.44); for each standard deviation increase in SOFA score (3.7 points), the risk of remaining intubated increased by 14% (HR = 1.14, 95% CI: 0.98‐1.33); and for each 1 L increase in fluid balance, the risk of remaining intubated increased by 11% (HR = 1.11, 95% CI: 1.04‐1.19). A nomogram was developed to predict the probability of extubation based on daily highest IAP for the day, SOFA score and fluid balance.ConclusionIAPs did not correlate with pulmonary compliance in critically ill patients. Increased IAP was associated with a longer duration of mechanical ventilation. A nomogram integrating daily IAP, SOFA score and fluid balance may be used to predict the duration of mechanical ventilation.
MC1R polymorphism associated with plumage color variations in Coturnix chinensis
Authors: Araguas R. M. , Sanz N. , Viñas J. , Vidal O. 
Published: July 2018

SummaryThe melanocortin 1 receptor (MC1R) gene was investigated as a candidate for plumage variations in Chinese painted quail, Coturnix chinensis. Four silent and two missense nucleotide polymorphisms were identified. The correspondent amino acid changes, p.Glu92Lys and p.Pro292Leu, were found in Blue Face and Red Breasted animals respectively. Blue Face is a melanic phenotype similar to the co‐dominant Extended Brown of Japanese quail, and both share the p.Glu92Lys mutation. The association of p.Pro292Leu with the recessive Red Breasted was confirmed in 23 animals from an experimental F2 cross.
Implementation of a new strategy to improve the peri‐operative management of neuromuscular blockade and its effects on postoperative pulmonary complications
Authors: Rudolph M. I. , Chitilian H. V. , Ng P. Y. , Timm F. P. , Agarwala A. V. , Doney A. B. , Ramachandran S. K. , Houle T. T. , Eikermann M. 
Published: July 2018

SummaryInappropriate dosing of neostigmine for antagonism of neuromuscular blockade has been associated with postoperative pulmonary complications. We evaluated the effects of a quality improvement initiative tailored to optimise the use of neostigmine in antagonising neuromuscular blockade on postoperative pulmonary complications, costs and duration of hospital stay. The quality improvement initiative consisted of: a reduction in available neostigmine aliquot sizes; a cognitive aid; an educational component; and a financial incentive for the intra‐operative documentation of train‐of‐four measurement before administration of neostigmine. We conducted a pre‐specified analysis of data obtained in our quality improvement study. Additional analyses were conducted in a propensity‐matched cohort. An interrupted time series design was used to discriminate between the intervention and a counterfactual scenario. We analysed 12,025 consecutive surgical cases performed in 2015. Postoperative pulmonary complications occurred in 220 (7.5%) of 2937 cases pre‐intervention and 568 (6.3%) of 9088 cases post‐intervention. Adjusted regression analyses showed significantly a lower risk of postoperative pulmonary complications (OR 0.73 (95%CI 0.61–0.88); p = 0.001), lower costs (incidence rate ratio 0.95 (95%CI 0.93–0.97); p < 0.001) and shorter duration of hospital stay (incidence rate ratio 0.91 (95%CI 0.87–0.94); p < 0.001) after implementation of the quality improvement initiative. Analyses in a propensity‐matched sample (n = 2936 per group) and interrupted time series analysis (n = 27,202 cases) confirmed the findings. Our data show that a local, multifaceted quality improvement initiative can enhance the quality of intra‐operative neuromuscular blocking agent utilisation, thereby reducing the incidence of postoperative pulmonary complications.