bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial
Authors: Lima Maria da Glória , Gussi Maria Aparecida 
Published: April 2018

É com muita satisfação que lançamos o segundo exemplar especial temático dedicado a saúde mental, na Revista Tempus Actas em Saúde Coletiva. O primeiro foi em 2010, cujos temas retrataram as conquistas obtidas e os desafios presentes com a aprovação da Lei 10.2016/2001. Nesta edição, foram contempladas contribuições sobre estratégias e dispositivos de cuidado construídos nos diferentes cenários brasileiros, na sua diversidade e desigualdade social, criação de diferentes saberes e práticas para avançar na instituição do modelo psicossocial, as estratégias processos de organização da gestão e do trabalho em saúde mental, a partir do dispositivo estratégico dos
Centros de Atenção Psicossocial – CAPS, bem como, sua integração com a Atenção Básica. ...
PROCESSO DE INCUBAÇÃO COMO ESTIMULADOR DE INOVAÇÃO: UM ESTUDO COM EM-PRESAS INCUBADAS DE BASE TECNOLÓGICA
Authors: Minello Italo Fernando , Marinho Estêvão Da Silva , Bürger Rafaela Escobar 
Published: April 2018

O presente trabalho teve como objetivo analisar o processo de incubação enquanto estimulador de inovação em empresas incubadas, na percepção de gestores que vivenciam este processo na ITSM. Para isto foram entrevistados oito gestores de negócios incubados. Os questionamentos abordaram a percepção dos gestores acerca do processo de incubação e seu papel enquanto estimulador de inovação. Para a análise utilizou-se a técnica de análise de conteúdo Bardin (2011). A partir da perspectiva dos incubados, a ITSM proporcionou oportunidades de desenvolvimento para os indivíduos, bem como para seus negócios, estimulando ações suas inovadoras por meio de um caráter experiencial.
QSAR and Docking Studies of DATA Analogues as HIV-1 Reverse Transcriptase Inhibitors
Authors: Tong Jianbo , Lei Shan , Zhan Pei , Qin Shangshang , Wang Yang 
Published: April 2018

Background:
Acquired Immunodeficiency Syndrome (AIDS) caused by Human Immunodeficiency
Virus (HIV) has seriously threatened human health, so development of new, selective
and safe non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) remains a high priority for
medical research. Diaryltriazine (DATA) have been identified as a new class of potent nonnucleoside
HIV-1 Reverse Transcriptase (RT) inhibitors. The study deals with Topomer CoMFA
(Comparative Molecular Field Analysis) and molecular docking to explore the important features of
DATA analogues for exerting potent HIV-1 RT inhibitors activity.

Methods:
In this work, 40 DATA analogues were studied using a combination of molecular modeling
techniques including Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR),
molecular docking, and Topomer CoMFA were used to build 3D-QSAR models.

Results:
The results show that the Topomer CoMFA analysis has the cross-validation q2 = 0.800,
SDCV = 0.45, the non-cross-validated r2 = 0.958, SD = 0.21, and the correlation coefficient of external
validation Q2 ext = 0.965 showed that the model is reasonable and credible, and has a good predictive
ability. Then binding mode pattern of the compounds to the binding site of enzyme was
confirmed and the mechanism of drug and acceptor was studied by docking studies, the results
showed that the drug and GLU138, LYS101, THR139 sites have an obvious function, these researches
have provided an useful information for designing more effective HIV-1IN inhibitors.

Conclusion:
A series of 40 DATAs analogues was subjected to a 3D-QSAR study. Using Topomer
CoMFA 3D-QSAR method built model, and the model has shown a good predictive and statistical
validation. Substituent with low electronic density in the R5 and R3 positions and substituent with
high electronic density in the R2 and C2 positions will increase the biological activity, small substituent
on R4 positions and naphthyloxy as the spacer group C6 substituent hydrophobic will increase
biological activity. This effect is supported by Topomer CoMFA contour map and docking
results of HIV-1RT inhibition active site, the results of the 3D-QSAR and docking analyses have
provided a guide for the synthesis of new putative inhibitors for HIV-1RT to improved inhibitory
activity.
Physicochemical Characterization of Curcumin Loaded Chitosan Nanoparticles: Implications in Cervical Cancer
Authors: Khan Md. Asad , Zafaryab Md. , Mehdi Syed H. , Ahmad Irfan , Rizvi Md. Moshahid A. 
Published: April 2018

Background:
Curcumin is a potent anticancer agent and has great potential efficacy against different
types of cancers. A major disadvantage of curcumin, however, is its poor solubility and bioavailability.

Objective:
The aim of the present work is to synthesize chitosan and curcumin-loaded chitosan nanoparticles
and their characterization through various physicochemical methods and cellular uptake in cervical cancer cell
line SiHa.

Method:
Chitosan nanoparticles were synthesized through the method of ionic gelation of chitosan with sodium
Tripolyphosphate (TPP). In addition, the internal structure of chitosan nanoparticles and curcumin loaded chitosan
nanoparticles were characterized by DLS, UV-Visible spectrophotometer, DSC, LCMS and LDH assay.

Results:
The studies presented demonstrate that curcumin-loaded chitosan nanoparticles showed increased uptake
in the SiHa cells as compared to free curcumin and chitosan nanoparticles did not show any significant
uptake in SiHa cell line. The curcumin-loaded chitosan nanoparticles released more lactate and lower ATP as
compared to native curcumin in cervical cancer lines such as SiHa, CaSki and HeLa.

Conclusion:
Thus, chitosan based curcumin nanoparticles could be used as a potent vector / delivery agent for
drug targeting in the treatment of cervical cancer.
Kadar IL-6 dan IL-10 Serum pada Tahapan Inflamasi di Rattus norvegicus yang terinfeksi Candida albicans
Authors: Masfufatun Masfufatun , Tania Putu Oky Ari , Raharjo Loo Hariyanto , Baktir Afaf 
Published: April 2018

Insiden kandidiasis sangat tinggi di dunia yang disebabkan Candida albicans. Agen antifungi telah banyak dikembangkan, namun resistensi terhadap antifungi masih menjadi suatu permasalahan. Resistensi antifungi ini diakibatkan oleh kemampuan C. albicans dalam membentuk biofilm. Terbentuknya biofilm dari infeksi C. albicans diawali oleh proses inflamasi. Proses inflamasi oleh Candida albicans terjadi pada beberapa tahap yang salah satu indikatornya adalah dilepaskannya sitokin proinflamasi (IL-6) dan anti inflamasi (IL-10). Penelitian ini bertujuan untuk mengetahui kadar IL-6 dan IL-10 pada tiap tahapan inflamasi C. albicans pada intestinal pada tikus putih. Penelitian ini menggunakan 32 ekor tikus wistar (Rattus norvegicus) yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan perlakuan. Kelompok perlakuan diinokulasi dengan C. albicans. Variabel yang diukur adalah kadar IL-6 dan IL-10 pada hari ke-7, 14, 21, 28 dan 35 setelah inokulasi C. albicans. pengambilan data sebanyak 5 kali dilakukan untuk mewakili tahapan pembentukan biofilm candida. Respon imun pada setiap tahap pembentukan biofilm ditunjukkan dengan kadar sitokin IL-6 dan IL-10 serum darah dengan metode ELISA. Hasil penelitian menunjukkan bahwa kadar IL-6 dan IL-10 pada hari ke-7 dan 14 sebesar 0pg/mL. Pada hari ke 28 telah terjadi proses inflamasi akutÂ pelepasan IL-6 dan IL-10 dengan kadar tertinggi masing-masing 31,75Â±9,99pg/mLdan 757,94Â±576,73pg/mL. Selanjutnya pada hari ke-35, kadar sitokin IL-6 dan IL-10 masing-masing mulai menurun menjadi 28Â±11,53pg/mL dan 349,5Â±188,48pg/mL. Respon imun tubuh mulai terjadi pada tahap awal pembentukan biofilm C. albicans intestinal tikus, sehingga kedepannya dapat dikembangkan terapi imunomodulator terhadap kandidiasis sehingga dapat menghambat pembentukan biofilm C. albicans.
Kiwifruit under plastic covering: impact on fruit quality and on orchard microclimate
Authors: Chiabrando V. , Giacalone G. 
Published: April 2018

Italy has a preeminent rank in kiwifruit industry, being the first exporter and the second largest producer after China. However, in the last few years kiwifruit yields and the total cultivated area considerably decreased, due to the disease spread of the bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa). Bacterial canker has affected significantly orchards productivity and consequently has caused severe economic losses in all major areas of kiwifruit cultivation, including Italy,and considerable damage to the international kiwifruit industry.Several climatic conditions and cultural practices affect the development of the bacterial canker.Orchard hygiene, restrictions on the movement of nursery plants, orchard management and cultural practices, chemical and biological controls and breeding programs are being employed to limit the diffusion of the disease and help kiwifruit orchards to survive and produce. A possible way seems to be the modification of environmental conditions and it is being explored through the building of plastic covers over the orchards. This research work is focused on the impact of plastic cover on fruit quality, microclimate conditions and incidence of Psa. To evaluate the impact of plastic cover on microclimate, quality of fruits and disease incidence the following parameters were evaluated: climatic parameters (temperature, PAR), quality parameters (color, fruit firmness, titratable acidity, °Brix, vitamin C), disease incidence (%). The use of a permanenttunnel modify light intensity and microclimate without any negative consequences on kiwifruits quality. Covering a kiwifruit orchard with a protective canopy reduces the spread of Psa throughout the orchard when covers are constructed over vines with low levels of infection.The use of plastic covers ensure the production of the current and future kiwifruit without compromising the quality of the fruit, but future trials will provide further information clarifying the effectiveness of the actual crop covers.
Agriculture and Food Security in Mozambique
Authors: Ferrão Jorge , Bell Victoria , Cardoso Luis Alfaro , Fernandes Tito 
Published: April 2018

The objective of this short review is to contribute to the debate on the role of agriculture transformation in the development process and as an engine to reduce poverty and improve general wellbeing through better access to nutrients in Mozambique. Agricultural services are organized by Provinces but still there is no accurate data on food production, consumption and trade trends in a large sample. It is recognized the complexity of the food security concept and the need of a multidimensional definition and approach. The increase in agricultural productivity can probably be seen as a necessary but not a sufficient condition to achieve long term food security in Mozambique or Sub-Saharan Africa. Competing views about the relevance of agriculture for growth and development imply different policy priorities in Africa.
Caso clínico de Elefantiasis Verrucosa
Authors: Castro Bocanegra Verónica Del Carmen , Salcedo Hurtado José 
Published: April 2018

Se reporta caso de paciente femenino de 29 años de edad con diagnóstico de elefantiasis verrucosa en miembro inferior izquierdo complicada con una necrosis dérmica severa y sepsis de tejidos blandos. Con aproximadamente año de internación. Se describen los parámetros clínicos, radiográficos y plan de tratamiento. Lo relevante de este caso radica en lo infrecuente de esta patología, las complicaciones presentadas en la paciente y lo satisfactorio del tratamiento consistente en el manejo multi e interdisciplinario con el apoyo con insumos de tecnología y técnicas avanzadas en el manejo de heridas e intervención nutricional especializado como se describirá en el desarrollo del caso clínico.
Descripción de política pública de primera infancia en el Instituto Colombiano de Bienestar Familiar - Cereté
Authors: Chavez Almario Dilia Cristina , Hanna Lavalle Mónica 
Published: April 2018

Objetivo: describir la Política Pública de Primera Infancia del Instituto Colombiano de Bienestar Familiar del municipio de Cerete, 2015. Metodología: descriptiva, retrospectiva, enfoque cuantitativo. Población 3.819 personas, muestreo aleatorio simple y muestra 349 usuarios. Se realizó una encuesta estructurada, con trece (13) ítems. Resultados: el 60,5% y el 65,5% de los usuarios de los Hogares Comunitarios de Bienestar Tradicional y Hogares Fami, manifiestaron que el mobiliario es inadeacuado, a diferencia de centros de desarrollo infantil en los cuales el 88,2% de usuarios contaban con mobiliario adecuado y seguro. Asi mismo el 69,7% y el 62,7% de los Hogares Comunitarios de Bienestar Tradicional y Fami manifestraron no contar con buenas condiciones de aseo y limpieza, el 85,2% de usuarios de los centros de desarrollo infantil afirmaron lo contrario. En cuanto al desarrollo de capacidades motrices y cognitivas, los padres afirmaron que los niños(as) beneficiarios de los programas alcanzaron buen desarrollo 85,8% y 82,8% en estas àreas desde que asisten a estos centros. La morbilidad sentida fue Enfermedad Diarreca Aguda 70%, Infecciòn Respiratoria Aguda 60,5%. La confianza que proyectan los coordinadores de los programas a los padres tuvo una media de 48,8% . La Política Pública de Primera Infancia del instituto, posee fortalezas en los centros de desarrollo infantil y se percibió debilidad en otros programas con relación a estándares establecidos por normatividad vigente.
Responsabilidad social para el apalancamiento del desarrollo sustentable en universidades públicas
Authors: Urdaneta Urdaneta Geovanni Antonio , Mendoza Montenegro Álvaro De Jesús 
Published: April 2018

Resumen
El propósito de esta investigación fue analizar la responsabilidad social para el apalancamiento del desarrollo sustentable en Universidades Públicas. El estudio se fundamentó teóricamente en autores como: Ancer (2014), Rebeil (2012), Moreno, Uriarte y Topa (2010), Briceño (2010), Leff (2008), Pelekais y Aguirre (2008), Morros y Videl (2005) entre otros. Se trata de una investigación asociada al paradigma positivista, de tipo explicativa con un diseño de campo no experimental, transeccional. La población estuvo conformada por tres universidades de gestión pública, seleccionando un censo poblacional de treinta y ocho (38) sujetos, a quienes se les aplicaron dos instrumentos desarrollados por el investigador conformado por 24 y 18 reactivos; sometidos a un juicio de diez expertos para su validación y una prueba piloto a 10 sujetos para determinar la confiabilidad por medio del coeficiente Alfa de Cronbach obteniendo valores alfa de 0.96 y 0.98 respectivamente, indicativo de que son altamente confiable. Dentro de los resultados obtenidos se concluyó que en las organizaciones universitarias objeto de estudio, se existe poca presencia de los componentes: Acciones de obligación y sensibilidad social como aspectos que determinan el cumplimiento de la responsabilidad social como política de gestión. De igual modo, se evidenció que la proporción del bienestar humano y ecológico se muestra debilitada en los indicadores estratégicos de desarrollo sustentable, por tal motivo, se revela un comportamiento desfavorable en las autoridades de las universidades públicas, develando que en su gestión estos indicadores no son asumidos corresponsablemente, menos aún la creación de condiciones sustentables.
San Basilio de Palenque y su organización social: El kuagro como referente histórico cultural
Authors: De Ávila Torres Dimas 
Published: April 2018

Este artículo se da a conocer la importancia del kuagro para los integrantes de la comunidad del Palenque de San Basilio en el departamento de Bolívar en Colombia; es una instancia social-administrativa donde sus miembros sienten su vida social potencializada, allí fortalecen la cultura que los caracteriza, su identidad como palenqueros. Además, les facilita el respeto por las diferencias y el reconocimiento de los otros. Los kuagro hacen parte del patrimonio inmaterial de San Basilio de Palenque, fueron conformados durante la época de la colonia como mecanismo de resistencia ante las condiciones infrahumanas que les tocó vivir a los esclavizados africanos. Son grupos etario conformado por mujeres y hombres alrededor de los seis a nueve años de edad, que se fortalece en la pubertad y perdura hasta la muerte. Un kuagro Puede estar conformado por mitad masculina, mitad femenina, solo por hombre o solo por mujeres. Para la comunidad palenquera ser miembro de un kuagro, es contar con el apoyo incondicional de hombres y mujeres que basados en unas reglas intrínsecas de la organización siempre estarán para apoyarse en cualquier circunstancia teniendo en cuenta los valores que los caracteriza. Entre estos tenemos: Respeto, solidaridad, consideración, amor y lealtad entre otros. El kuagro conformado desde la época de la colonia como una estrategia militar para defenderse de los esclavizadores europeos, hoy pervive como un legado ancestral que dinamiza toda la cultura de la comunidad de San Basilio de Palenque.
Evolución del derecho a la salud en el ordenamiento jurídico Colombiano.
Authors: Ahumada Vargas Irma Raquel , Muñoz Lozano Cesar Noriel 
Published: April 2018

En el presente artículo de investigación se pondrá de relieve que el Estado Social de Derecho se fundamenta en la dignidad humana, por lo que la aplicación de los derechos fundamentales es una forma de garantizar al ser humano su bienestar, el de la familia y la comunidad, por ello mediante el presente artículo de reflexión se muestra el tratamiento jurídico que se le ha dado al derecho a la salud, pasando conceptualmente con el transcurrir tiempo como derecho de carácter prestacional, luego su reconocimiento por conexidad con otro derecho fundamental hasta convertir el derecho a la salud en un derecho fundamental autónomo mediante Ley Estatutaria 1751 de 2015.

Palabras claves:
Derecho a la salud, dignidad humana, derecho por conexidad, prestación social, derecho fundamental autónomo
Do Auditors Respond to Media Coverage? Evidence from China
Authors: Gong Stephen X. , Gul Ferdinand A. , Shan Liwei 
Published: April 2018

SYNOPSIS
This paper examines whether news coverage of client firms is associated with their audit fees. Using data from China listed firms during 2004–2013, we find that high coverage client firms are on average charged higher audit fees, irrespective of the media tone. This positive association is stronger for large auditors than for small auditors, and for bad news than for good news. The main results hold for both state-owned enterprises (SOEs) and non-SOEs, and for both politically connected and non-connected firms. The results are robust after controlling for the effects of information asymmetry, auditor choice, internal corporate governance, and alternative measurements of the key variables. Overall, our evidence is supportive of the view that auditors assess high coverage clients as higher risk audits requiring greater audit efforts. We conclude that the financial news media plays a disciplining role in China through its potential to trigger reputational sanctions and regulatory action.
BK virus: microbiology, epidemiology, pathogenesis, clinical manifestations and treatment
Authors: Sriaroon Chakrapol , Greene John N. , Vincent Albert L. , Tucci Veronica T. , Kharfan-Dabaja Mohamed A. , Sandin Ramon 
Published: April 2018

Abstract
Background: BK virus infection is common but is usually asymptomatic. However, it can become life threatening as severe hemorrhagic cystitis (HC) or the polyomavirus-associated nephropathy (PVAN) particularly in immune compromised and transplant recipients. Some investigators have studied the pathophysiology and there are anecdotal and uncontrolled studies of therapy with few conclusions allowing treatment guidelines. Objectives: Summarize literature review of current knowledge concerning the nature, epidemiology, pathophysiology, diagnosis and treatment of this common virus infection. Results: HC is a not uncommon and often misdiagnosed infection from BK virus. It is usually self limited but can become life threatening in immune compromised patients. PVAN threatens survival of transplanted kidneys and is difficult to differentiate from rejection without sophisticated molecular diagnostic technology. We have sufficient information for making a diagnosis of BK virus disease by using clinical, serological and molecular technology. Studies using manipulation of immunosuppression and a variety of antiviral agents, including cidofovir, leflunomide, intravenous immunoglobulin, vidarabine, fluroquinolones, have been published but most were uncontrolled reports of few cases. Cidofovir offers some promise but more must be learned before there is hope for evidence-based treatment guidelines.
Association between serum interleukin-6 levels and severity of perinatal asphyxia
Authors: Boskabadi Hassan , Afshari Jalil Tavakol , Ghayour-Mobarhan Majid , Maamouri Gholamali , Shakeri Mohammad T , Sahebkar Amirhossein , Ferns Gordon 
Published: April 2018

AbstractBackground: Perinatal asphyxia is a major cause of neurologic morbidity and mortality in infants. Objective: Determine the serum level of interleukin-6 (IL-6) in neonates with perinatal asphyxia and its relation to the severity of hypoxic-ischemic encephalopathy and short term neurological outcome. Methods: Serum IL-6 levels were measured at birth, and at 24 and 48 hour post-partum in 37 consecutive uninfected neonates with peri-natal asphyxia and 45 randomly selected healthy newborns. Results: Serum IL-6 concentrations in the infants who developed hypoxic-ischemic encephalopathy was 43 folds higher compared to values in the normal infants (p < 0.001) and 1.9 folds higher as compared to infants with asphyxia who did not subsequently develop hypoxic-ischemic encephalopathy (p <0.001). Serum IL-6 concentrations were also related to the degree of hypoxic-ischemic encephalopathy and neurologicaldevelopmental outcomes at the time of discharge. Conclusion: Serum levels of IL-6 increased in neonates with asphyxia, and this was most pronounced in neonates with adverse outcomes.
Improved vascular repair is relevant to enhanced renal function with vasodilators in early stage of chronic kidney disease
Authors: Futrakul Narisa , Futrakul Prasit 
Published: April 2018

Abstract
Background: Treatment with vasodilators can improve renal function in early stage of chronic kidney disease (CKD) patients. Objective: Study the mechanism of vascular repair in 20 CKD patients associated with actual creatinine clearance greater than 60 mL/min/1.73m2 (mean 84+24 mL/min/1.73m2) who had been under treatment with vasodilators. Results: Initial study on angiogenic factors revealed a low value of VEGF, no significant change in VEGF-R1, whereas antiangiogenic factors showed elevated angiopoietin-2 and no significant change in VEGF-R2. Initial actual creatinine clearance was significantly depleted and fractional excretion of magnesium (FE Mg) was elevated significantly. Follow-up study showed improved VEGF and a significant decline in angiopoietin-2. Such improved vascular repair coincided with enhanced creatinine clearance. Conclusion: Improved renal function can be achieved by vasodilators under environment favourable for adequate vascular repair.