bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process evaluation protocol for a cluster randomised trial of a complex, nurse-led intervention to improve hypertension management in India
Authors: Srinivasapura Venkateshmurthy Nikhil , Mc Namara Kevin , Koorts Harriet , Mohan Sailesh , S Ajay Vamadevan , Jindal Devraj , Malipeddi Bhaskara Rao , Roy Ambuj , Tandon Nikhil , Prabhakaran Dorairaj , Worsley Tony , Maddison Ralph , O’Reilly Sharleen 
Published: May 2019

IntroductionIndia has high prevalence of hypertension but low awareness, treatment and control rate. A cluster randomised trial entitled ‘m-Power Heart Project’ is being implemented to test the effectiveness of a nurse care coordinator (NCC) led complex intervention to address uncontrolled hypertension in the community health centres (CHCs). The trial’s process evaluation will assess the fidelity and quality of implementation, clarify the causal mechanisms and identify the contextual factors associated with variation in the outcomes. The trial will use a theory-based mixed-methods process evaluation, guided by the Consolidated Framework for Implementation Research.Methods and analysisThe process evaluation will be conducted in the CHCs of Visakhapatnam (southern India). The key stakeholders involved in the intervention development and implementation will be included as participants. In-depth interviews will be conducted with intervention developers, doctors, NCCs and health department officials and focus groups with patients and their caregivers. NCC training will be evaluated using Kirkpatrick’s model for training evaluation. Key process evaluation indicators (number of patients recruited and retained; concordance between the treatment plans generated by the electronic decision support system and treatment prescribed by the doctor and so on) will be assessed. Fidelity will be assessed using Borrelliet al’s framework. Qualitative data will be analysed using the template analysis technique. Quantitative data will be summarised as medians (IQR), means (SD) and proportions as appropriate. Mixed-methods analysis will be conducted to assess if the variation in the mean reduction of systolic blood pressure between the intervention CHCs is influenced by patient satisfaction, training outcome, attitude of doctors, patients and NCCs about the intervention, process indicators etc.Ethics and disseminationEthical approval for this study was obtained from the ethics committees at Public Health Foundation of India and Deakin University. Findings will be disseminated via peer-reviewed publications, national and international conference presentations.Trial registration numberNCT03164317; Pre-results.
Process evaluation of complex interventions tested in randomised controlled trials in musculoskeletal disorders: a systematic review protocol
Authors: Ribeiro Daniel C , Abbott J Haxby , Sharma Saurab , Lamb Sarah E 
Published: May 2019

IntroductionThe effectiveness of complex interventions for the management of musculoskeletal disorders has been estimated in many randomised clinical trials (RCTs). These trials inform which interventions are the most effective, however they do not always inform how an intervention achieved its clinical outcomes, nor how and what elements of an intervention were delivered to patients. Such information is useful for translating findings into clinical practice. A few process evaluation studies have been conducted alongside RCTs and a variety of methods have been used. To gain a better understanding of current practices of process evaluation in RCTs in musculoskeletal disorders, this systematic review is designed to answer the following research question: How are process evaluation of complex interventions tested in RCTs in musculoskeletal disorders being conducted?Methods and analysisWe will systematically search seven electronic databases (MEDLINE, SCOPUS, CINAHL, PsycINFO, EMBASE, Web of Science and Cochrane database) from the date of inception to August 2018 for studies on process evaluation of RCTs on non-surgical and non-pharmacological management of musculoskeletal disorders. We will include qualitative and quantitative studies conducted alongside RCTs, reported with the RCTs or separate studies that assessed interventions for musculoskeletal disorders. Two reviewers will screen abstracts and apply prespecified inclusion criteria to identify relevant studies, extract the data and assess the risk of bias within included studies. We will follow recommendations from the ‘Cochrane Qualitative and Implementation Methods Group Guidance Series’ when assessing methodological strengths and limitations of included studies. We will use a narrative synthesis to describe findings.Ethics and disseminationEthical approval is not required as this review will not collect original data. Findings from this systematic review will be presented at a scientific conference and published in a peer reviewed journal.PROSPERO registration numberCRD42018109600
Temporal trends and socioeconomic differences in acute respiratory infection hospitalisations in children: an intercountry comparison of birth cohort studies in Western Australia, England and Scotland
Authors: Moore Hannah C , de Klerk Nicholas , Blyth Christopher C , Gilbert Ruth , Fathima Parveen , Zylbersztejn Ania , Verfürden Maximiliane , Hardelid Pia 
Published: May 2019

ObjectivesAcute respiratory infections (ARIs) are a global cause of childhood morbidity. We compared temporal trends and socioeconomic disparities for ARI hospitalisations in young children across Western Australia, England and Scotland.DesignRetrospective population-based cohort studies using linked birth, death and hospitalisation data.Setting and participantsPopulation birth cohorts spanning 2000–2012 (Western Australia and Scotland) and 2003–2012 (England).Outcome measuresARI hospitalisations in infants (<12 months) and children (1–4 years) were identified through International Classification of Diseases, 10th edition diagnosis codes. We calculated admission rates per 1000 child-years by diagnosis and jurisdiction-specific socioeconomic deprivation and used negative binomial regression to assess temporal trends.ResultsThe overall infant ARI admission rate was 44.3/1000 child-years in Western Australia, 40.7/1000 in Scotland and 40.1/1000 in England. Equivalent rates in children aged 1–4 years were 9.0, 7.6 and 7.6. Bronchiolitis was the most common diagnosis. Compared with the least socioeconomically deprived, those most deprived had higher ARI hospitalisation risk (incidence rate ratio 3.9 (95% CI 3.5 to 4.2) for Western Australia; 1.9 (1.7 to 2.1) for England; 1.3 (1.1 to 1.4) for Scotland. ARI admissions in infants were stable in Western Australia but increased annually in England (5%) and Scotland (3%) after adjusting for non-ARI admissions, sex and deprivation.ConclusionsAdmissions for ARI were higher in Western Australia and displayed greater socioeconomic disparities than England and Scotland, where ARI rates are increasing. Prevention programmes focusing on disadvantaged populations in all three countries are likely to translate into real improvements in the burden of ARI in children.
Treatment of bitches with acquired urinary incontinence with oestriol
Authors: Mandigers P. J. J. , Nell T. 
Published: May 2019

Oestriol, a naturally occurring short‐acting oestrogen, was used to treat acquired urinary incontinence in 129 bitches selected by 48 veterinary practitioners in the Netherlands, Belgium, France and Germany. The dogs were treated daily for 42 days with oestriol tablets, using a self‐controlled study design. The dogs were examined and blood sampled at the beginning and end of the trial. According to the veterinary practitioners 83 per cent of the dogs either became continent or improved, but the others showed no change or became worse. The owners reported similar results: 82 per cent of the dogs responded to treatment and the others did not. The dose and treatment schedule for each dog were established on the basis of clinical efficacy. Mild and transient oestrogenic effects such as swelling of the vulva and attractiveness to male dogs were observed soon after the treatment began and at the higher dose schedule used in 12 of the dogs. A haematological examination of 1 4 of the dogs revealed no abnormalities.
What do we know about Neotropical trap‑nesting bees? Synopsis about their nest biology and taxonomy
Authors: Costa Camila Cristina Ferreira da , Gonçalves Rodrigo Barbosa 
Published: May 2019

Cavity-nesting bees are enigmatic because they are difficult to observe in the wild, hence trap-nests (man-made cavities) provide the means by which these bees may be studied. Trap-nests is an efficient methodology to study these bees and are common worldwide. These traps have been used for a variety of reasons, including inventories, to examine pollen load, to study habitat disturbance, and bee conservation. However Neotropical trap-nesting bees’ taxonomy and biology are still poorly known and here we provide a review about these subjects. We searched for trap-nest bee studies in the Neotropical Region using Google Scholar and ISI Web of Science at any time in the past to December 2017. We found 109 independent studies, most of which were from Brazil (87 studies), followed by Argentina (10 studies), and other countries had fewer than five studies each. A total of 140 species, 24 genera, 10 tribes and three subfamilies were reported in trap-nests. Nest architecture was described for only 49 species. Taxonomy is only well-known for 14 genera, somewhat known for seven and is essentially unavailable for three genera. Construction material, closing plug and cell shape are similar among species in the same tribes and genera. Vestibular and intercalary cells, and the preliminary plug are variable, even at the specific level. Apinae is the most studied group with available data for all genera recorded in trap-nests. Colletinae is the least-studied group and nothing is known for their nesting biology. Megachilinae is intermediate, with some studies of taxonomy and nesting. We suggest that further trap-nest studies should provide more detailed information on nest architecture and construction materials, including explicit mention of structures that are absent. All Neotropical bees need more taxonomic studies, but some, such as Hylaeus and Megachile, require more attention since Hylaeus is essentially unknown and Megachile is very common on trap-nests.
Constructing a Textual Tradition: Salafī Commentaries on al-ʿAqīda al-ṭaḥāwiyya
Authors: Shiliwala Wasim 
Published: May 2019

AbstractAlthough the Salafī movement prides itself on its doctrinal purity, it has recently embraced the creed of Abū Jaʿfar al-Ṭaḥāwī (d. 321/933), which diverges from Salafī beliefs on a few significant topics such as the nature of faith. This paper accounts for this phenomenon by examining the scholarly production around the text, and by considering the strategies employed by modern commentators to deal with problematic lines. I argue that for the Salafī movement, the issues found in this text are outweighed by the polemical imperative of constructing a Salafī textual tradition.
A story of nasal horns: two new subspecies of Iguana Laurenti, 1768 (Squamata, Iguanidae) in Saint Lucia, St Vincent &amp; the Grenadines, and Grenada (southern Lesser Antilles)
Authors: BREUIL MICHEL , VUILLAUME BARBARA , SCHIKORSKI DAVID , KRAUSS ULRIKE , MORTON MATTHEW N. , HAYNES PIUS , DALTRY JENNIFER C. , CORRY ELIZABETH , GAYMES GLENROY , GAYMES JOANNE , BECH NICOLAS , JELIĆ MIŠEL , GRANDJEAN FRÉDÉRIC 
Published: May 2019

The Lesser Antilles, in the Eastern Caribbean, were long considered to have only two species in the genus Iguana Laurenti 1768: the Lesser Antillean iguana Iguana delicatissima, which is endemic to parts of the Lesser Antilles, and the Common green iguana Iguana iguana, which also occurs throughout Central and South America. No subspecies are currently recognised. However, herpetologists and reptile collectors have pointed out strong physical differences between some of the island populations of Iguana iguana and those from the continent. Drawing on both morphological and genetic data, this paper describes two subspecies of the Common green iguana Iguana iguana from the southern Lesser Antilles, specifically the countries of Saint Lucia Iguana iguana sanctaluciae and Iguana iguana insularis from St Vincent & the Grenadines, and Grenada. The form on the island of Saint Vincent has not been identified. The new subspecies are described based on the following unique combination of characters: Presence of high median and medium to small lateral horns on the snout; Small subtympanic plate not exceeding 20% of the eardrum size; Two or three scales of decreasing size anterior to the subtympanic plate; Fewer than ten small to medium triangular gular spikes; Medium sized dewlap; Low number of small to medium dispersed nuchal tubercles; Dark brown iris, with the white of the eye visible; Oval, prominent nostril; Short and relatively flat head; High dorsal spines; No swelling of the jowls in reproductively active males. Iguana iguana sanctaluciae has in adults vertical black stripes on body and tail and a black dewlap whereas Iguana iguana insularis is pale grey or creamy white in adults. Both subspecies are globally threatened by unsustainable hunting (including the pet trade) and by invasive alien species, including hybridization from invasive iguanas from South and Central America (I. iguana iguana and I. rhinolopha, considered here as full species) that have become established in all three countries. The authors call for stronger measures to conserve the remaining purebred Iguana i. insularis and Iguana i. sanctaluciae ssp. nov. throughout their ranges and for further research to identify other cryptic species and subspecies of Iguana in the Lesser Antilles.
Exploration of purinergic receptors as potential anti-migraine targets using established pre-clinical migraine models
Authors: Haanes Kristian A , Labastida-Ramírez Alejandro , Blixt Frank W , Rubio-Beltrán Eloisa , Dirven Clemens M , Danser Alexander HJ , Edvinsson Lars , MaassenVanDenBrink Antoinette 
Published: May 2019

Background The current understanding of mechanisms behind migraine pain has been greatly enhanced with the recent therapies targeting calcitonin gene-related peptide and its receptor. The clinical efficacy of calcitonin gene-related peptide-blocking drugs indicates that, at least in a considerable proportion of patients, calcitonin gene-related peptide is a key molecule in migraine pain. There are several receptors and molecular pathways that can affect the release of and response to calcitonin gene-related peptide. One of these could be purinergic receptors that are involved in nociception, but these are greatly understudied with respect to migraine. Objective We aimed to explore purinergic receptors as potential anti-migraine targets. Methods We used the human middle meningeal artery as a proxy for the trigeminal system to screen for possible anti-migraine candidates. The human findings were followed by intravital microscopy and calcitonin gene-related peptide release measurements in rodents. Results We show that the purinergic P2Y13 receptor fulfills all the features of a potential anti-migraine target. The P2Y13 receptor is expressed in both the human trigeminal ganglion and middle meningeal artery and activation of this receptor causes: a) middle meningeal artery contraction in vitro; b) reduced dural artery dilation following periarterial electrical stimulation in vivo and c) a reduction of CGRP release from both the dura and the trigeminal ganglion in situ. Furthermore, we show that P2X3 receptor activation of the trigeminal ganglion causes calcitonin gene-related peptide release and middle meningeal artery dilation. Conclusion Both an agonist directed at the P2Y13 receptor and an antagonist of the P2X3 receptor seem to be viable potential anti-migraine therapies.
Effect of Prenatal Waterpipe Tobacco Smoke Exposure on Cardiac Biomarkers in Adult Offspring Rats
Authors: Al-Sawalha Nour A. , Al-Filali Maria S. , Alzoubi Karem H. , Khabour Omar F. 
Published: May 2019

Introduction: The prevalence of waterpipe tobacco smoke (WTS) consumption is increased among pregnant woman. Prenatal cigarette smoke exposure increased the risk of developing cardiovascular diseases in offspring. The current study examined the effect of prenatal WTS exposure on inflammatory profile, oxidative stress, and cardiac biomarkers in adult offspring rats. Methods: Female rats received WTS (2 hours per day) or fresh air 1 day prior to mating and throughout the pregnancy period. The body and heart masses were measured in male offspring rats. The level of oxidative stress biomarkers, nitrate, inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-α]), and gene expression of protein kinase C epsilon, angiotensin 2 receptor one, and transforming growth factor beta1 were measured in cardiac tissue homogenates of 13-week-old male offspring rats. Results: Prenatal WTS exposure reduced body weight and increased heart to body weight ratio ( P < .05). Prenatal WTS exposure did not affect oxidative stress biomarkers (superoxide dismutase, glutathione peroxidase, and thiobarbituric acid reactive substances) but significantly increased catalase activity and nitrate level ( P < .05) in cardiac tissue of adult male offspring rats. In addition, prenatal exposure to WTS did not affect cardiac level of TNF-α and IL-6 as well as the gene expression of different cardiac modulators in adult male offspring rats ( P > .05). Conclusion: Prenatal WTS exposure has detrimental consequences on adult offspring rats by increasing the ratio of heart to body mass, increasing the catalase activity and nitrate level in cardiac tissue of adult male offspring rats.
Acute Outcomes With a Novel Plaque Modification System in Real-World Femoropopliteal Lesions
Authors: Zeller Thomas , Lopez Louis , Pigott John P. 
Published: May 2019

Purpose: To report outcomes of a multicenter feasibility study using the FLEX Vessel Prep (VP) System, a novel technology that facilitates plaque incision and lumen gain in stenosed or occluded femoropopliteal arteries prior to balloon angioplasty. Materials and Methods: Two hundred fifty-five patients (mean age 71.8±9.1 years) were treated with the FLEX VP System at 38 centers between December 2015 and November 2017. Average lesion length was 133±88 mm. Average baseline stenosis was 92%±11%; 112 (44.3%) of 253 patients presented with a chronic total occlusion. Conventional or drug-coated balloon (DCB) angioplasty was performed in all patients after vessel preparation. Vessel measurements were derived from angiograms acquired at baseline, after FLEX passage, and after subsequent ancillary procedures. Logistic regression analyses were performed to identify baseline or procedure variables that predicted the need for provisional stenting. Results: Average percent reduction in vessel stenosis following treatment with the FLEX VP System was 27%±17%. No flow-limiting dissection, vessel perforation, or embolization was observed; 15 (5.9%) patients had minor (type A or B) dissections. Provisional stenting was performed in 49 (19.2%) patients. Average stenosis following angioplasty ± stenting was 9.1%±7.4%; 9 (3.6%) patients had significant residual stenosis ≥30%. Logistic regression analyses found that patients with dissections, longer lesions, and those receiving conventional balloon dilation alone were most likely to undergo stenting. Conclusion: In a real-world patient population with long, complex femoropopliteal lesions, use of the FLEX VP System as vessel preparation for angioplasty improved acute outcomes compared to historical controls. The rate of provisional stenting was low, and no serious vessel complications were observed.
Modified Efficient and Simple Method for Biological Spill Cleanup
Authors: Vijayan Viji , Sern Benson Ng Beng , Johnson Barbara 
Published: May 2019

Introduction: Spill response procedures are an important aspect of laboratories where infectious materials are handled. The decades-old conventional method of spill cleanup uses paper towels to cover the spill. It requires 2 staff and involves a considerable amount of bending and squatting and being able to balance in those positions while wearing personal protective equipment (PPE). In this article, we describe a method that simplifies spill cleanup and compares it to the conventional method. The simplified method can be easily conducted by 1 person, takes about half the time, generates less waste, and reduces the amount of time spent in contaminated areas. Objective: The objective is to describe a modified, simple method of spill cleanup. Methods: A mock spill was created and a spill response initiated per the institution’s procedure. The simplified procedure uses a pail filled with decontaminant and a household mop dripping with the decontaminant. Mopping is done from the noncontaminated area toward the contaminated area so the spill does not spread. Mopping is done more than once, and all the materials used, including the mop(s), are disposed as biohazardous material. Results: The simplified spill cleanup process described here can be performed by just one person and does not require bending and squatting while wearing PPE. The kit is very simple, consisting of a pail and a mop, which are common household tools familiar to most people. Conclusion: The mop-and-pail methodology is simple, requires only one staff member, generates less biological waste, and requires less training and practice while effectively cleaning the spill.
Association of heart rate variability with regional difference in senility death ratio: ALLSTAR big data analysis
Authors: Hayano Junichiro , Kisohara Masaya , Yoshida Yutaka , Sakano Hiroyuki , Yuda Emi 
Published: May 2019

Objectives: Senility death is defined as natural death in the elderly who do not have a cause of death to be described otherwise and, if human life is finite, it may be one of the ultimate goals of medicine and healthcare. A recent survey in Japan reports that municipalities with a high senility death ratio have lower healthcare costs per late-elderly person. However, the causes of regional differences in senility death ratio and their biomedical determinants were unknown. In this study, we examined the relationships of the regional difference in senility death ratio with the regional differences in heart rate variability and physical activity. Methods: We compared the age-adjusted senility death ratio of all Japanese prefectures with the regional averages of heart rate variability and actigraphic physical activity obtained from a physiological big data of Allostatic State Mapping by Ambulatory ECG Repository (ALLSTAR). Results: The age-adjusted senility death ratio of 47 Japanese prefectures in 2015 ranged from 1.2% to 3.6% in men and from 3.5% to 7.8% in women. We compared these ratios with the age-adjusted indices of heart rate variability in 108,865 men and 136,536 women and of physical activity level in 16,661 men and 21,961 women. Heart rate variability indices and physical activity levels that are known to be associated with low mortality risk were higher in prefectures with higher senility death ratio. Conclusion: The regional senility death ratio in Japan may be associated with regional health status as reflected in heart rate variability and physical activity levels.