bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision medicine for patients with salivary gland neoplasms: Determining the feasibility of implementing a next-generation sequencing-based RNA assay in a hospital laboratory
Authors: Sura Gloria Hopkins , Hsu Jim , Mody Dina R. , Thomas Jessica S. 
Published: November 2024

Objective:
Diagnosing neoplasms of the salivary gland is challenging, as morphologic features of these tumors are complex, and well-defined diagnostic categories have overlapping features. Many salivary gland neoplasms are associated with recurrent genetic alterations. The utilization of RNA-based targeted next-generation sequencing (NGS) panels for the detection of cancer-driving translocations and mutations is emerging in the clinical laboratory. Our objective was to conduct a proof-of-concept study to show that in-house molecular testing of salivary gland tumors can enhance patient care by supporting morphologic diagnoses, thereby improving therapeutic strategies such as surgical options and targeted therapies.

Material and Methods:
Residual formalin-fixed paraffin-embedded salivary gland neoplasm specimens from a cohort of 17 patients were analyzed with the Archer FusionPlex Pan Solid Tumor v2 panel by NGS on an Illumina NextSeq550 platform.

Results:
We identified structural gene rearrangements and single nucleotide variants in our patient samples that have both diagnostic and treatment-related significance. These alterations included PLAG1, MAML, and MYB fusions and BRAF, CTNNB1, NRAS, and PIK3CA mutations.

Conclusion:
Our RNA-based NGS assay successfully detected known gene translocations and mutations associated with salivary gland neoplasms. The genetic alterations detected in these tumors demonstrated potential diagnostic, prognostic, and therapeutic value. We suggest that incorporating in-house ancillary molecular testing could greatly enhance the accuracy of salivary gland fine needle aspiration cytology and small biopsies, thereby better guiding surgical decisions and the use of targeted therapies.
A clinical study to evaluate the efficacy of yogaraja rasayana in pandu roga (w.s.r. to iron deficiency anemia)
Authors: Mishra Manish , Dwivedi K. K. , Gupta Kanchan , Kumar Amit 
Published: November 2024

Objectives:
To evaluate the efficacy of Yogaraja rasayana in pandu.

Materials and Methods:
A non-randomized and open single arm study was conducted on 100 patients suffering from pandu.

Results:
The trial drug showed encouraging results in the overall health status of selected cases of pandu [with special reference (w.s.r.) iron deficiency anemia (IDA)] with >75% improvement in 61 cases and >50% improvement in 36 patients.

Conclusion:
Yogaraja rasayana is an unique herbo-mineral combination containing iron rich content ‘mandoor’ along with other herbal drugs helps in increasing the hemoglobin percentage in cases of pandu.
Microhabitat of Endangered Species, Lonchura oryzivora in Malang City, Indonesia
Authors: Aryanti Nirmala Ayu , Abdillah Fahmi Maulana , Sari Andini Maya , Pradipta Naresvara Nircela , Yuda Pramana 
Published: November 2024

Malang City, located in Java, Indonesia, faces significant anthropogenic pressures but remains an important habitat for the endangered Java sparrow (Lonchura oryzivora). Understanding how Java sparrows adapt to environments with high levels of human activity is essential for their conservation. This study focused on identifying the distribution of Java sparrows and investigating their habitat selection within Malang City. The bird positions were recorded within the tree canopy, and the frequency of canopy use by the birds was determined. Living in the middle of the city impacts the metabolism of birds, as indicated by taking samples and measuring the levels of lead found in their droppings and vegetation used. Encounters near the center of human activity show they can utilize buildings and vegetation they utilize. The Java sparrows predominantly utilize plant parts at the tree level, particularly focusing on the middle canopy part of the edge (TTt) and the middle part (TT). Laboratory tests revealed that the plants utilized by the Java sparrow contain high lead levels. Therefore, to conserve the Java sparrow, it is crucial to improve the quality of their habitat to make it more natural and conduct regular health monitoring to ensure their well-being.
KONSELING INDIVIDUAL DENGAN TEKNIK MOTIVATIONAL INTERVIEWING (MI) PADA PASIEN RAWAT JALAN DI POLIKLINIK PRATAMA ADDICTION RECOVERY BNN
Authors: Muthmainna Nurul , Mayasari Ros , Fauziah Siti , Syamsu Khairunnisa 
Published: November 2024

Tujuan penelitian ini adalah untuk mengetahui layanan konseling individual dengan teknik motivational interviewing (MI) pada pasien rawat jalan di Poliklinik Pratama BNN Provinsi Sulawesi Tenggara. Jenis penelitian ini merupakan penelitian kualitatif yang bertujuan untuk mengetahui dan menganalisa proses layanan konseling individual dengan teknik MI pada pasien rawat jalan di Poliklinik Pratama BNN Provinsi Sulawesi Tenggara. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Analisis data dalam penelitian ini dilakukan dengan teknik analisis deskriptif yaitu dengan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukan layanan rehabilitasi yang ada di Poliklinik Pratama BNN Provinsi Sulawesi ada dua, yaitu rehabilitasi medis dan sosial. Layanan rehabilitasi sosial dengan metode rawat jalan di Poliklinik Pratama BNN Provinsi Sulawesi Tenggara dalam pelaksanaannya menggunakan layanan konseling individual dengan teknik MI. Dalam proses pelaksanaan konseling individual dengan teknik MI pada klien, konselor menggunakan pendekatan religiusitas. Pendekatan religiusitas ini dilakukan pada pertemuan 7-8 konselor dan klien. Faktor pendukung dalam penelitian ini adalah kemampuan konselor dalam melakukan konseling. Adapun faktor penghambatnya yaitu (1) Faktor Internal; Ada beberapa konselor tidak paham tentang teknik MI, tidak dapat membangun rapport serta sarana dan prasarana kurang memadai. (2) Faktor Eksternal; Jarak tempuh.
Atypical delayed ventriculoperitoneal shunt infection following hysteroscopic polypectomy: illustrative case
Authors: Bialek Shannan , Stevens Baylee , Tavakol Sherwin A. , Alkozah Maria , Graffeo Christopher S. 
Published: November 2024

BACKGROUND
A 36-year-old female with a history of congenital hydrocephalus, treated with ventriculoperitoneal (VP) shunt placement at 3 months of age and a shunt revision at 9 years of age, presented with erythema, induration, and drainage of an abdominal incision through which the distal catheter of her VP shunt had been implanted many years prior. She had no recent risk factors for infection apart from a minor transvaginal gynecological procedure that involved hysteroscopy with dilation and curettage for uterine polyps.

OBSERVATIONS
Abdominal wound cultures grew Cutibacterium acnes, Corynebacterium species, and Mycobacterium chelonae. She was managed with initial externalization, followed by complete explantation of her shunt system following a successful clamp trial; in tandem, the atypical polymicrobial infection was treated with a prolonged regimen of intravenous antibiotics followed by oral antibiotics and close monitoring of the wound, which healed appropriately.

LESSONS
Although the majority of shunt infections occur due to a characteristic set of organisms within an expected time frame, this case emphasizes the importance of a thorough workup and follow-up for shunt-treated patients with potential infections—even when they fall outside the usual window or have an atypical presentation—for the possibility of uncommon infecting organisms.
https://thejns.org/doi/10.3171/CASE24472
Penetrating intracranial injury from a pencil in a pediatric patient: illustrative case
Authors: Liu Eva , Su Hsuan Ming , Toyota Patrick , Newton Braeden D. , Coote Nicole , Marciniuk Kristen , Ahmed Syed Uzair , Kelly Michael E. , Peeling Lissa 
Published: November 2024

BACKGROUND
Intracranial penetrating injuries from a pencil are exceptionally rare. The most common mechanism is a child running while holding a pencil. Potential consequences of intracranial pencil injury include direct trauma to brain structures, vascular injury, and intracranial abscess formation.

OBSERVATIONS
A 3-year-old girl was at daycare and had fallen while running with a pencil. Computed tomography showed a pencil penetrating the left parietal bone through the left temporal lobe, terminating in the posterior limb of the internal capsule. Cerebral angiography was performed prior to the removal of the pencil to rule out vascular injury. Angiography of the left carotid artery revealed slight irregularity in the left M2 but no active extravasation. The patient was then taken to the operating room to have the pencil removed. Postoperatively, she did well and was discharged home after 6 days with no neurological deficits.

LESSONS
Pencils are rare causes of intracranial injury in children. Definitive vascular imaging prior to pencil removal to rule out vascular injury and minimize the risk of hemorrhage after removal is recommended. Intraoperative irrigation and debridement, followed by antibiotics, are recommended to avoid abscess formation. Follow-up vascular imaging is recommended to rule out pseudoaneurysm.
https://thejns.org/doi/10.3171/CASE24494
Long-term survival in a patient with Li-Fraumeni syndrome–associated giant cell glioblastoma treated with nivolumab: illustrative case
Authors: Mitchell Macy , Restrepo-Orozco Andres , Verhey Leonard H. , Vitaz Todd 
Published: November 2024

BACKGROUND
Li-Fraumeni syndrome (LFS) is characterized by p53 germline mutations and a high predisposition to cancers including glioblastoma (GBM), the most common and aggressive primary malignant brain tumor in adults. Despite current therapies, the 5-year survival rate is 5%–10%. The authors report a case with a durable long-term response to immunotherapy with checkpoint inhibition in a patient with LFS-associated GBM.

OBSERVATIONS
An 18-year-old female presented after a syncopal episode and left leg weakness and was found to have a right frontal tumor. She underwent gross-total resection of the tumor (grade IV giant cell GBM IDH-wildtype, MGMT unmethylated, associated with a p53 germline mutation), radiation, and chemotherapy. On later imaging, increased enhancement was demonstrated, which raised concerns for tumor recurrence, and she underwent stereotactic radiosurgery followed by lomustine and procarbazine. These agents were later replaced with bevacizumab after a second resection, negative for recurrent glioma. Subsequently, nivolumab was added, given concerns for tumor progression, and the patient showed improvement within 5 months. The patient has continued nivolumab monotherapy and has had progression-free survival for more than 7 years.

LESSONS
Despite advances in treatment, the median survival of patients with GBM is only 15 months. This case highlights the potential of immunotherapy with PD-L1 checkpoint inhibition in improving outcomes for LFS–associated GBM patients.
https://thejns.org/doi/10.3171/CASE24539
THE INFLUENCE OF CLIMATIC AND ENERGY-EFFICIENT FACTORS ON THE FORMATION OF THE ARCHITECTURAL ENVIRONMENT OF EDUCATIONAL BUILDINGS IN IRAN
Authors: Emamianfar Ali , Tretiak Yuliia , Kosarevska Raddamila 
Published: November 2024

The article highlights a comprehensive approach to the architectural design of school buildings in Iran, with an emphasis on the climatic features of cold and humid regions. Special attention is paid to temperate and cold humid zones located mainly in the north and west of the country, including the coast of the Caspian Sea and the Alborz mountain range.
The focus of the research is the analysis of architectural features adapted to the specifics of the climate of these regions, such as the orientation of the building, air conditioning systems, classroom lighting, the use of vegetation to create shading, as well as the features of the form, interior design and choice of materials. Particular attention is paid to the energy efficiency of school buildings, as schools are significant consumers of energy, including electricity, water and gas. Architectural solutions based on a deep understanding of climatic conditions can significantly improve the energy efficiency of schools, reduce fuel consumption and contribute to the creation of a comfortable and healthy learning environment.
The article emphasizes the importance of an integrated approach to architectural design, which takes into account climatic features to increase energy efficiency and create optimal conditions for learning and development of students in schools in cold and humid regions of Iran.
Mesh Smoothing of 3D Prosthesis and Orthosis Models
Authors: Sufelfa A. R. , Voznesensky A. S. , Kaplun D. I. 
Published: November 2024

Introduction. Formation of a contact surface in prosthetics and orthotics is crucial for the restoration of human musculoskeletal functions. This paper considers specific features of methods currently used for denoising of a 3D model surface obtained by optical scanning. An algorithm for manufacturing an individual prosthetic and orthopedic product is developed. The current literature reports no similar methods, which may be explained by the widespread use of gypsum technology for the manufacture of prostheses and orthoses.Aim. Research and development of digital filtration methods for 3D meshes obtained by optical scanning for further modeling of individual prosthesis and orthosis modules.Materials and methods. It is proposed to optimize the pre-processing stage of 3D scanned models by applying denoising and smoothing processes. In total, 50 optical 3D scans were selected for testing via the following denoising algorithms: bilateral filtering, vertex-based anisotropic smoothing, mean and median filtering applied to face normals.Results. The study was conducted using 3D scans of lower limb stumps and Chenault brace orthoses and corsets provided by the Institute of Prosthetics and Orthotics, Albrecht Federal Scientific and Educational Centre of Medical and Social Expertise and Rehabilitation. А method for denoising and smoothing of the 3D model surfaces for the manufacture of prosthetic and orthopedic products is proposed. The SNR metric difference SNR – δ-SNR (with averaging by scans and SNR values) and average execution time were calculated. The bilateral filtration method with δ-SNR = 11.3362 dB and a runtime of 8.8900 s showed the highest efficiency.Conclusion. The proposed methods for the pre-processing stage of 3D optical scans showed high efficiency in the formation of 3D models of prosthesis and orthosis modules. The results obtained can be used for automating the process of manufacturing various prosthetic and orthopedic products, which is particularly relevant in the context of the modern geopolitical situation.
Measurement of Sea Surface Characteristics from Radar Images Using Gradient Methods
Authors: Laptev K. Yu. , Sokolov N. V. , Mikhailov V. N. , Bogachev M. I. , Vorobev E. N. 
Published: November 2024

Introduction. Remote sensing and monitoring of the sea surface are of great importance in such fields, as operational oceanography, environmental monitoring, etc. The ability to quickly assess the state of the sea surface is particularly relevant in areas that pose a danger to shipping, where rapid and accurate response becomes critical. Modern radars represent information as digital image series largely reminiscent to a frame series in a video stream, thus enabling the use of gradient methods originally designed for and proven successful in video analysis.Aim. Determination of sea wave characteristics from radar images using gradient motion estimation methods. The use of gradient methods will allow implementing additional tools for processing radar image series obtained from sea backscatter.Materials and methods. To assess the characteristics of the sea surface from radar images, gradient methods were used. To train the methods, a series of synthetic images of the sea surface obtained by mathematical modeling were used. To evaluate the effectiveness of the gradient methods, two representative experimental radar image series provided by the Institute of Oceanography RAS were employed.Results. Using gradient methods, the direction and speed of waves were calculated from several consecutive radar observations. Regression models of the dependence of calculated values on the specified ones were constructed. The Farneback and TV-L1 methods proved to be effective especially for obtaining the direction of the sea waves.Conclusion. An algorithm for evaluating speed and direction of the sea surface displacement using gradient methods was pre-trained using simulated model data. The implemented methods and algorithms for assessing the speed and direction of sea waves were validated using two experimental image series obtained from shipborne navigational radars.
Separation of Cyclostationary Signals and Interference in Transmission Lines of Printed Circuit Boards Based on Independent Component Analysis
Authors: Kuznetsov Yu. V. , Baev A. B. , Konovalyuk M. A. , Gorbunova A. A. 
Published: November 2024

Introduction. When developing and testing high-speed communication links of digital electronic devices, the pulse shape of electrical signals and interference in transmission lines is commonly controlled using eye diagrams. Partial pulse responses are estimated by modern multi-channel testing and measuring equipment using specific testing procedures. Aim. To develop an approach to blind identification of a wireline communication signal measured by a digital oscilloscope in microstrip transmission lines.Materials and methods. The study was carried out using a communication signal model composed of a superposition of the information signal, intersymbol interference, and crosstalk interference from an adjacent transmission line, with the symbols of these signal sources being assumed statistically independent. The implemented blind identification method makes it possible to separate three components of the signal and evaluate their partial pulse responses. The proposed procedure for signal separation includes preliminary processing of the data measured by principal component analysis followed by an analysis of independent components based on fourth-order statistical characteristics.Results. The performance of the proposed signal separation method is demonstrated using the results of parallel and independent data processing measured in microstrip transmission lines in an experimental setup with two closely spaced printed circuit boards. A comparison of blind signal separation methods is carried out based on second-order statistics, fourth-order cumulants, and independent component analysis. The proposed method of independent component analysis demonstrated the highest efficiency in terms of minimum bit error probability for blind signal separation with arbitrary partial pulse responses, which was confirmed by simulation results.Conclusion. The developed approach to blind identification of wireline signal parameters measured in high-density integrated digital electronic devices extends the range of systems for circuit design and testing of multi-channel high-speed communication lines.
General manager succession dynamics in MNE foreign subsidiaries
Authors: Li Arthur 
Published: November 2024

<p>Subsidiary general manager (GM) succession selection is a critical process in multinational enterprises (MNEs). Previous research, grounded in organizational learning and routines, has suggested that GM succession dynamics typically follow either an acceleration or a deceleration momentum. However, as we investigated succession decision-making heuristics through interviews with MNE managers, we observed neither acceleration nor deceleration. Instead, we found some consistent succession dynamics. Within this consistency, we found variations in decision-making models among subsidiaries—some adopting a rule-based approach with a short succession dynamic, some adopting a goal-based approach with a moderate succession dynamic, and others adopting a people-based approach with a long succession dynamic. Underlying these models were bounded rationality, bounded reliability, and their unexpected interactions. Our study sheds light on the critical role of managers in subsidiary management, enriches international business theorizing on the subsidiary GM succession process, and refines the boundary conditions of organizational learning. The central message is that looking solely at GM succession dynamics through an organizational learning lens may risk overlooking relevant causal mechanisms. To make the theorizing on the dynamics of subsidiary management more fertile, the behavioral model should account for the idiosyncrasies of decision-making as well as the heuristics of decision-makers.</p>
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SME DEVELOPMENT AND ART COMMUNITY FOR DEVELOPING JELEKONG CULTURAL TOURISM AREA
Authors: SUDRAJAT Jajat , RUSTNE Mira , YUDISTIRA Dimas , TIARA Kania Alma , MARYANI Maryani , UTOMO Satrio Matin 
Published: November 2024

The purpose of this paper is to analyze the results of the collaboration between the Ministry of Cooperatives and SMEs and the Alliance of Indonesia Entrepreneurship Study Programs to collaborate to develop a roadmap for national entrepreneurship development. As a case study, the Binus Bandung Entrepreneurship Study Program collaborates with SMEs and the Jelekong Art Community of Bandung Regency. Jelekong Tourism Village which is the center of worldwide painting art. The method used in analyzing this collaboration uses the Case Study method through interviews with the Jelekong art and culture community. In conclusion, they need help from educational institutions, namely lecturers and students who have competence in the field of digital marketing, to develop the marketing of their paintings through social media and other electronic media, so that the exhibition activity plan is a solution to increase marketing and tourism branding of Jelekong Art Village is first identifying the type of UKM and community to be guided at the time of the exhibition, then each UKM and Community will be fostered by lecturers according to their competence and will involve Binus Bandung and other Binus lecturers as well as Satu University Bandung who are interested in this activity.
La búsqueda de objetos robados (Doce Tablas, tab. I. 20; VIII. 15 A). Contexto etnológico, histórico y jurídico de un misterio.
Authors: Coello Joaquín Muñiz 
Published: November 2024

El contenido de las Doce Tablas, de mediados el siglo V a. de C., constituye un texto muy inseguro, defectuoso y de valor muy desigual, como documento jurídico que fue reflejo de la Roma de ese período y anterior. Por la escasa y ambigua información que nos ha llegado, el asunto del robo y sobretodo, la búsqueda de los objetos robados, apenas resumido en los dos términos que sobre ello nos ha llegado, - lance et licio ,- fue ya un enigma para la sociedad romana posterior, y ha seguido generando abundante controversia y bibliografía desde hace más de un siglo. Creemos que analizar los problemas de transmisión y ampliar el contexto histórico, geográfico y cultural, a otras culturas tanto antiguas como primitivas actuales, puede servir para obtener una visión más aproximada del significado de aquel mandato arcaico.