bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of transpyloric feeds in extremely low birth weight infants at risk of severe bronchopulmonary dysplasia—a single center experience
Authors: Nagarkatti Ahana , Sarkar Shikha , Anuar Amirul , Hussain Naveed 
Published: November 2024

IntroductionThe incidence of severe BPD (sBPD), defined as needing oxygen or positive pressure at 36 weeks corrected gestational age (CGA), has remained unchanged. These infants are at risk for developing late pulmonary hypertension (LPHN) or needing surgical interventions such as Gastrostomy Tubes (GT) or Tracheostomy Tubes (TT). The finding of pepsin in the lungs of infants who were extremely low birth weight (ELBW) with sBPD has led to the speculation that gastroesophageal reflux (GER) and aspiration could contribute to their lung disease. Micro-aspiration-reducing strategies such as Transpyloric feeds (TpF) have not been well studied.ObjectivesTo compare ELBW infants with sBPD managed with or without TpF and determine the difference between the two groups for (i) illness severity, (ii) LPHN, (iii) need for GT, and (iv) TT; the secondary aim was to study the TpF group to (i) evaluate the change in Respiratory Severity Score (RSS) before and after TpF, and (ii) evaluate the time taken to affect the change in RSS.MethodsIn this retrospective study there were 229 ELBW infants with sBPD (78 in the TpF group, 151 in the non-TpF group). SPSS software was used for univariate analyses.ResultsThere was no difference in sex or race. TpF group had (i) a lower BW, GA, higher severity of illness (ii) higher incidence of LPHN (p &lt; 0.05), (iii) higher need for GT (p &lt; 0.001) and TT (p &lt; 0.001). In the TpF group, 60 who were on TpF for pulmonary protection from micro aspiration (lung protection group), had significantly improved RSS (p &lt; 0.05), and symptoms within 45 days in 57 out of 60 infants (95%). They improved their respiratory status by 14 days, and 80% of responders could be identified by 21 days after initiation. In the 18 that TpF was started for documented airway protection (airway protection group), there was a higher need for GT or TT.ConclusionsTpF could play an essential role in the management of ELBW infants with sBPD. Considering the limitations of a single center retrospective study, prospective randomized control trials are needed to confirm these findings.
Interactions of warfarin with COVID-19 vaccine/drugs, monoclonal antibodies, and targeted anticancer agents from real-world data mining
Authors: Gao Yan , Huang Qingsong , Li Jun , He Junsheng , Qian Fang , Yi Juanjuan 
Published: November 2024

ObjectiveThis study aims to examine the unresolved drug-drug interactions of warfarin using real-world data.MethodsElectronic medical records from a hospital in Shanghai, China, were used to summarize drug-related problems (DRPs) among inpatients taking warfarin in 2022. Additionally, adverse event data for warfarin from January 2004 to December 2023 were extracted from the U.S. adverse event reporting system to evaluate the bleeding risk associated with the concomitant use of warfarin and COVID-19 Vaccine/drugs, monoclonal antibodies, and targeted anticancer agents.ResultsThe electronic clinical records yielded 180 cases, of which 130 cases (72.22%) had 276 DRPs identified. DRP5 (n = 172, 62.32%) was identified as the most common issue, comprising 145 drug interactions and 27 adverse drug reactions (ADRs). The analyses of warfarin ADR records (n = 53,709) from the database revealed that tocilizumab (adjusted Odds Ratio (aOR): 3.39 [95% CI: 1.77–7.03]; P &lt; 0.001), ibrutinib (aOR: 2.53 [1.61–4.19]; P &lt; 0.001), and cabozantinib (aOR: 3.34 [1.40–9.85]; P = 0.013) significantly increased the risk of warfarin bleeding. In contrast, nirmatrelvir–ritonavir (aOR: 0.32 [0.14–0.69]; P = 0.004), adalimumab (aOR: 0.72 [0.56–0.93]; P = 0.012), golimumab (aOR: 0.18 [0.05–0.50]; P = 0.002), tofacitinib (aOR: 0.51 [0.29–0.86]; P = 0.013), and dabrafenib (aOR: 0.17 [0.04–0.55]; P = 0.007) significantly reduced the risk of bleeding when combined with warfarin. Remdesivir combined with warfarin was associated with a statistically significant increase in bleeding events (P = 0.047); while the risk was not significant after adjusting for age and sex (aOR: 1.79; P = 0.2). No significant effect was observed with the COVID-19 vaccine (aOR: 0.89; P = 0.8).ConclusionDrug-drug interactions contribute to the adverse effects of warfarin. This study provides real-world evidence of newly identified drug interactions with warfarin. It reminds clinicians to monitor INR and adjust warfarin doses accordingly when used in combination with these medications.
Development and initial validation of the implicit internalized sexual orientation stigma affect misattribution procedure
Authors: Hall William J. , Dawes Hayden C. , Hannay Jason W. , Williams Denise Yookong , Frey Joseph J. , Srivastava Ankur , Chapman Mimi V. , Chen Ding-Geng , Wilson Amy Blank , Ramon Magdelene E. , Payne B. Keith 
Published: November 2024

IntroductionThis article describes the development and initial validation of a measure of implicit internalized stigma among queer people, the Implicit Internalized Sexual Orientation Stigma Affect Misattribution Procedure (Internal-SOS-AMP), a computer-administered sequential priming procedure.MethodsThe creation of the Internal-SOS-AMP involved a mixed-methods approach, including a literature review, expert interviews, stimuli selection and pilot testing, data collection from a large sample, reliability testing, correlational analyses, and confirmatory factor analysis. Psychometric testing was conducted with a national sample of 500 queer adults who completed two waves of data collection. Confirmatory factor analysis was used to evaluate two models: a one-factor model with internalized stigma specified as one overall construct and a two-factor model with internalized stigma specified as two constructs based on binary conceptions of gender (stigma regarding queer women and stigma regarding queer men).ResultsResults showed that the two-factor model best fit the data. This indicates that although implicit attitudes toward queer men and women are highly correlated, implicit internalized stigma differentiated by two gender stimuli groups (men and women) more accurately reflects the data. There was evidence of convergent validity as Internal-SOS-AMP scores showed small positive associations with explicit internalized stigma. Regarding divergent validity, Internal-SOS-AMP scores were inversely related to affirmation of a queer identity. Reliability results for the Internal-SOS-AMP showed good internal consistency and acceptable test–retest reliability.DiscussionThe creation of the Internal-SOS-AMP used best practices for measurement development. Psychometric findings show strong evidence of content validity, convergent validity, divergent validity, and reliability of the Internal-SOS-AMP.
The effect of Tai Chi on elderly depression: a systematic review and meta-analysis of randomized controlled trials
Authors: Zhu Fengya , Wang Yuan , Yin Shao , Liu Junqian , Zhong Yue , Li Liuying 
Published: November 2024

ObjectiveThis systematic review and meta-analysis assess the impact of Tai Chi on emotional well-being and quality of life in elderly individuals with depression.MethodsSearching six databases until October 20, 2024, including Embase, PubMed, Cochrane Library, Web of Science, SinoMed, and CNKI, for randomized controlled trials (RCTs). Participants were aged ≥60 and diagnosed with depression. Tai Chi served as the main intervention in the treatment group, with the control group receiving no exercise, or only health education. The primary outcomes focused on the improvement of depressive symptoms and quality of life. Data synthesis and meta-analysis were performed using Stata 15.1 software. The protocol of this study was registered on PROSPERO (ID: CRD42023479305).ResultsTai Chi, as the main intervention, significantly improved depressive symptoms as measured by the Geriatric Depression Scale (WMD = −5.99, 95% CI: −10.80 to −1.19, p = 0.015) compared to no exercise or health education. Subgroup analysis favored a six-month duration of Tai Chi, showing even greater benefits (WMD = −9.79, 95% CI: −13.90 to −5.69, p &lt; 0.001). However, Tai Chi did not demonstrate a significant advantage in improving participants’ scores on the Hamilton Depression Scale (WMD = −1.04, 95% CI: −3.84 to 1.76, p = 0.468).ConclusionOur results indicate that Tai Chi can significantly improve depressive symptoms and quality of life in elderly individuals with depression. As a daily exercise and mind–body therapy to alleviate the mood of the elderly, it is necessary to conduct more large-sample RCTs. Further research on the details of Tai Chi, such as movements, frequency, duration, and exercise periods, is essential for a dose–response relationship, contributing to the standardized promotion of Tai Chi.
The effect of sports participation on the social identity of Chinese university students
Authors: Ji Shuyu , Chen Shuwei , Yang Xiannan , Liu Tongshang , Wang Xiaolin 
Published: November 2024

ObjectiveStrengthening youth sports and comprehensively promoting the participation of Chinese university students in sports to enhance their social acceptance are key initiatives for delivering high-quality talent for China’s economic and social development.MethodsUsing the China Comprehensive Social Survey as the data source and considering social mentality and social identity, we constructed corresponding statistical models to explore how sports participation influences the social identity (class identity, economic status, and emotional belonging) of Chinese university students.ResultsRegarded from a holistic perspective, sports participation can enhance the social identity of college students in all its aspects, and the benefits of sports participation are positively related to its frequency. Under the condition of social mentality, sports participation has a positive effect on the social identity of college students in general and a nonsignificant effect only on certain dimensions. Under the social identity condition, the significance of sports participation for college students’ social identity decreases from lower to higher levels of education.ConclusionSports participation significantly enhances the social identity of Chinese university students, and the specific mechanism of the enhancement varies across the social mentality and social identity conditions. In this context, strengthening the role of sports participation in promoting the social identity of college students in the new era is necessary. Deepening the ideological content of physical education courses should be taken as the starting point to enhance the effectiveness of sports participation on the social identity of college students under the condition of social mentality. The effectiveness of sports participation on the social identity of college students with different social identities should be differentiated and enhanced.
The relationship between childhood psychological abuse and cyberbullying behavior among graduate students: the mediating role of negative coping style and trait anxiety
Authors: Shen Yi 
Published: November 2024

BackgroundAs a major public health problem, cyberbullying has been received widespread attention in recent years. However, most researches on cyberbullying are mainly focused on adolescents and college students, the underlying mechanisms of cyberbullying among graduate students have been relatively less investigated. From the perspectives of the general aggression model and attachment theory, this study aims to explore the relationship between childhood psychological abuse and cyberbullying behavior among graduate students, as well as the mediating roles of negative coping style and trait anxiety.Materials and methodsA total of 482 graduate students were surveyed using measures including the Childhood Psychological Abuse Scale, Simplified Coping Style Questionnaire, Self-Rating Anxiety Scale, and Cyberbullying Behavior Scale.Results(1) There were significant positive correlations between childhood psychological abuse, negative coping style, trait anxiety, and graduate students’ cyberbullying behavior; (2) Childhood psychological abuse could forecast graduate students’ cyberbullying behavior through the mediating effects of negative coping style and trait anxiety. This mediation process includes two pathways: the independent mediating effect of negative coping style and the chained mediating effect of negative coping style and trait anxiety.ConclusionNegative coping style and trait anxiety play mediating roles in the relationship between childhood psychological abuse and cyberbullying behavior among graduate students.
Physical activity and non-suicidal self-injurious behavior in Chinese adolescents: the chain mediating role of psychological capital and relative deprivation
Authors: Gao Yingzhe , Lu Changfen , Zhang Xiaoqiang , Han Beining , Hu Huijuan 
Published: November 2024

IntroductionPhysical activity has been shown to alleviate negative emotions. We examined whether physical activity is associated with lower non-suicidal self-injurious behavior in adolescents and the mediating and chain-mediating roles of psychological capital and relative deprivation in this association.Methods451 secondary school students (44.57% girls; ages 13-19) completed the Physical Activity Rating Scale, Adolescent Non-Suicidal Self-Injurious Behavior Scale, Psychological Capital Scale, and Adolescent Relative Deprivation Scale in their classrooms. In addition, this study used SPSS 26.0 for statistical data analysis and the SPSS macro program PROCESS 4.1 to explore the mediation role.ResultsRegression-based analyses showed that higher psychological capital and lower relative deprivation individually and sequentially mediated the association between physical activity and lower NSSI.ConclusionThese findings contribute to a deeper understanding of how and why physical activity affects adolescents’ non-suicidal self-injurious behaviors. At the same time, the result may provide new insights into prevention and intervention efforts for non-suicidal self-injurious behaviors in adolescents.
Current status and risk determinants of locomotive syndrome in geriatric cancer survivors in China—a single-center cross-sectional survey
Authors: Yang Yu-Ling , Su Hui , Lu Hui , Yu Hui , Wang Jing , Zhou Yu-Qing , Li Ling , Chen Ying 
Published: November 2024

ObjectiveTo assess the prevalence and risk determinants of locomotive syndrome (LS) in geriatric cancer survivors in China. To generate evidence-based insights for the clinical prevention and intervention strategies concerning LS in this vulnerable population, emphasizing the need for integrated public health initiatives focused on maintaining mobility among geriatric cancer survivors.MethodsSix hundred geriatric cancer survivors were recruited at a hospital in China. A demographic questionnaire, the International Physical Activity Questionnaire-Short (IPAQ-S), and the Geriatric Locomotive Function Scale (GLFS-25) were administered. Survivors were stratified into three physical activity level (PAL) groups via IPAQ-S scores: low, medium, and high. LS was operationally defined via GLFS-25 scores, with cut-offs established for LS-1, LS-2, and LS-3. Elevated GLFS-25 scores signified deteriorated motor function (MF) and increased severity of LS. Data analysis was done to investigate the risk determinants to the occurrence and exacerbation of LS among geriatric cancer survivors.ResultsOf the 524 geriatric cancer survivors who completed the study, 292 (55.7%) were diagnosed with LS, including 152 (29%) categorized under LS-1, 52 (9.9%) under LS-2, and 88 (16.8%) under LS-3. Univariate analysis indicated that variations in exercise habits, prior occupational type, presence of tumor metastasis or recurrence, visual impairments, somatosensory abnormalities, and PAL were significantly associated with differing occurrences and severities of LS (p &lt; 0.05). Ordinal logistic regression revealed that prior occupational type (OR = 0.466), tumor metastasis (OR = 0.404), tumor recurrence (OR = 0.341), and PAL (medium: OR = 7.178; high: OR = 1.984) were independent risk determinants modulating both the occurrence and severity of LS in cancer survivors (p &lt; 0.05).ConclusionThe occurrence of LS is notably elevated among geriatric cancer survivors in China, indicating a significant public health concern. Individuals who were previously engaged in non-physically demanding occupations and those with histories of tumor metastasis or recurrence, coupled with reduced PAL, demonstrate a heightened susceptibility and severities to LS. Early identification of these risk determinants is imperative for mitigating the onset and progression of LS. Comprehensive public health strategies, including regular screening programs, targeted physical rehabilitation initiatives, and community-based interventions, are essential to mitigate the onset and progression of LS in this vulnerable population, ultimately reducing its broader impact on aging-related health outcomes.
Impact of intensive hypertension criteria on multimorbidity prevalence and patterns in a multi-ethnic Chinese population
Authors: Liu Yezhou , Mi Baibing , Pei Leilei , Dang Shaonong , Yan Hong , Li Chao 
Published: November 2024

BackgroundThe impact of intensive hypertension criteria on multimorbidity prevalence and patterns remains understudied. We investigated the prevalence and patterns of multimorbidity using both the current (140/90 mmHg) and intensive (130/80 mmHg) hypertension criteria within a multi-ethnic Chinese population.MethodsData were obtained from the baseline survey of the Regional Ethnic Cohort Study in Northwest China, conducted from June 2018 to May 2019, which enrolled adults aged 35–74 years from five provinces. A total of 114,299 participants were included in this study. Multimorbidity was defined as the presence of at least two chronic diseases or conditions from a list of 26, ascertained through self-report and physical examination. Agglomerative hierarchical cluster analysis was employed to identify multimorbidity patterns. A hypertension-related multimorbidity pattern was identified and further analyzed. The prevalence of multimorbidity and hypertension-related pattern were analyzed in different subgroups, and subgroup cluster analyses were conducted stratified by sex, age, and ethnicity.ResultsApplying the intensive 130/80 mmHg hypertension criteria resulted in an increase in multimorbidity prevalence from 17.6% (20,128 participants) to 21.7% (24,805 participants) compared to the 140/90 mmHg criteria. Four distinct multimorbidity patterns were consistently identified: cardiometabolic, digestive-bone-kidney, respiratory, and mental-cancer. Hypertension consistently clustered within the cardiometabolic pattern alongside diabetes, acute myocardial infarction, angina, and stroke/TIA, with relatively stable proportions observed even under the 130/80 mmHg threshold.ConclusionThe revision of hypertension criteria significantly expands the population identified as having multimorbidity, without altering the identified multimorbidity patterns. Hypertension commonly co-occurs within the cardiometabolic cluster. These findings highlight the need for improved treatment and management strategies specifically targeting cardiometabolic multimorbidity.
Assessment of acceptance and associated factors of HIV pre-exposure prophylaxis among commercial female sex workers in drop-in centers selected sub-cities of Addis Ababa, Ethiopia
Authors: Berhe Trhas Tadesse , Asfaw Elefie Asfaw , Tedla Getachew Weldyohanes 
Published: November 2024

BackgroundGlobally, female sex workers (FSWs) face high risk of HIV, particularly in regions like sub-Saharan Africa. In Ethiopia and Addis Ababa, the impact is significant. Implementing WHO-recommended measures, such as pre-exposure prophylaxis (PrEP), is crucial to reducing new HIV infections and addressing service access disparities among FSWs. Thus this study aimed to assess the acceptance of Pre-Exposure Prophylaxis (PrEP) among commercial female sex workers in selected sub-cities of Addis Ababa, Ethiopia, 2022.MethodInstitution-based cross-sectional study design was conducted on three randomly selected sub-cities of Addis Ababa from June 20 to July 30, 2022. All (358) commercial sex workers available during the study period were included. A structured, pretested, and interviewer-administered questionnaire was used to collect the data. Logistic regression was used to identify factors associated with acceptance of pre-exposure prophylaxis and statistical significance was determined at p-value &lt;0.05. An odds ratio with a 95% confidence interval was used to measure association estimates.ResultA total of 358 female sex workers responded, 67.9% (95% CI: 63.7, 73.2%) were willing to take pre-exposure prophylaxis. Acceptability of pre-exposure prophylaxis was significantly associated with the accessibility of pre-exposure prophylaxis at easily reachable areas (AOR3.786; 95%CI: 1.449, 9.894) and knowledge about pre-exposure prophylaxis (AOR 3.270; 95%CI: 1.336, 8.001).ConclusionAcceptability of pre-exposure prophylaxis among female sex workers was 67.9% which is low. Accessibility of pre-exposure prophylaxis is an easily reachable area and knowledge of about it could significantly affect its acceptability.
Novel biosynthesis of silver nanoparticles using Ulva lactuca and their potential toward environment and agricultural purposes
Authors: Taibi Mariame , Aouji Marouane , Imtara Hamada , Abujaber Feras , Oubihi Asmaa , Ouannou Abdelmalek , Hajji Lhoussain , Shahat Abdelaaty A. , Noman Omar M. , Tarayrah Mahmoud , Bengueddour Rachid , Hassani Oussama 
Published: November 2024

IntroductionIn the global field of nanotechnology, the production of silver nanoparticles (AgNPs) is an environmentally beneficial technique. To prevent the diseases caused by many commonly used pesticides, it is essential to synthesize safe alternatives from low-cost sources.Material and methodsThis study focuses on the eco-friendly extracellular production of AgNPs using an aqueous extract of Ulva lactuca as a reducing agent in a silver nitrate solution. The biosynthetic reaction was confirmed through various analytical techniques, including ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and energy dispersive X-ray analysis (EDAX). Moreover, antioxidant activity was confirmed. It has also been evaluated against a variety of bacteria and fungi that have an impact on humans, animals, and plants.Results and discussionThe mean size of the nanoparticles (NPs) varied from 45–61 nm. The disk diffusion testing results show that, in comparison to the tested antibiotics, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Klebsiella pneumoniae were more responsive to U. lactuca-silver nanoparticles (U-AgNPs) extract. eldor 50% sc fungicide was used at the prescribed dose of 0.5 μL/mL, and the antifungal activity of aqueous and U-AgNPs extracts was examined at three concentrations of 0.62, 1.25, and 2.5 mg/mL. Through the suppression of spore germination, in vitro investigations demonstrated that U-AgNPs at varying doses greatly hindered the process of reproductive growth of Botrytis cinerea. Comparing U-AgNPs to the standard synthetic fungicide Teldor 50% sc, it is noteworthy to observe that a substantial control efficacy against tomato and strawberry gray mold was noticed, especially at concentrations of 2.5mg/mL on the entire tomato and strawberry plants and also on the detached leaves and fruits without causing any appearance damage. In summary, this study advances the field of agronanotechnology by demonstrating the potential application of a fungicide based on NPs to prevent gray mold on tomato and strawberry plants in greenhouse environments and throughout the postharvest phase.