bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le phallus en forme de Dieu
Authors: Smialek Eric 
Published: August 2019

Grâce aux réseaux par Internet, les fans et les musiciens de métal chrétien ont conçu diverses stratégies pour concilier leur identité religieuse avec leur identité sous-culturelle face à l’opposition du milieu international de la musique métal et de la droite chrétienne conservatrice. Pour étudier ces différents contextes, j’ai appliqué les théories de la formation de l’identité de la théorie de la psychanalyse (Lacan 2006 [1966]) à trois cas d’utilisation par des chrétiens de la musique métal en lien avec le culte : par le moine capucin et chanteur Cesare Bonizzi, par les groupes de métal extrême chrétien, comme Mortification (deathmétal chrétien) et Horde (unblackmétal), et dans le cadre des cérémonies religieuses appelées « messes métal » organisées en Finlande et en Colombie. En comparant le discours et les paroles de ces groupes aux débats des fans, j’ai examiné comment ces derniers et les musiciens du genre métal chrétien perçoivent leurs Autres musicaux et religieux, ainsi que la manière dont ces perceptions influent sur la conscience qu’ils ont d’eux-mêmes.
Effect of Exercise Interventions on Anxiety in People with Multiple Sclerosis
Authors: Gascoyne Claudia , Karahalios Amalia , Demaneuf Thibaut , Marck Claudia 
Published: August 2019

Abstract

Background:
Evidence suggests that exercise can alleviate symptoms associated with multiple sclerosis (MS). However, it is unclear whether exercise alleviates symptoms of anxiety, present in one-third of people with MS. This systematic review and meta-analysis investigates whether exercise interventions are effective in reducing anxiety in people with MS.

Methods:
CINAHL, Embase, MEDLINE, PsycINFO, and the Cochrane Controlled Clinical Trials Register were searched to identify relevant randomized controlled trials (RCTs) published up to March 30, 2018. The primary outcome was postintervention difference in anxiety scores between intervention and control groups. Using a restricted maximum likelihood random-effects model, standardized mean differences were pooled and heterogeneity was estimated. Risk of bias was assessed using an a priori modified Cochrane Risk of Bias 2.0 tool.

Results:
Four RCTs with 133 participants were included. Exercise type included walking, aerobic activities, and cycling. Intervention duration ranged from 8 to 26 weeks. The pooled standardized mean difference in anxiety score was −0.16 (95% CI, −0.50 to 0.19), without heterogeneity. Two studies had high risk of bias, and two had some risk of bias.

Conclusions:
Based on available RCT data, exercise does not seem to have an effect on anxiety in people with MS. These results should be interpreted with caution because studies had concerns of bias and small sample sizes, and anxiety was not the primary outcome measure. Future studies should exhibit sufficient reporting standards, alongside publishing protocols. There is opportunity to investigate the effect of exercise in people with MS experiencing clinically relevant levels of anxiety rather than in the general MS population.
12 Grand challenges in single-cell data science
Authors: Laehnemann David , Köster Johannes , Szczurek Ewa , McCarthy Davis J , Hicks Stephanie C , Robinson Mark D , Vallejos Catalina A , Beerenwinkel Niko , Campbell Kieran R , Mahfouz Ahmed , Pinello Luca , Skums Pavel , Stamatakis Alexandros , Stephan-Otto Attolini Camille , Aparicio Samuel , Baaijens Jasmijn , Balvert Marleen , de Barbanson Buys , Cappuccio Antonio , Corleone Giacomo , Dutilh Bas , Florescu Maria , Guryev Victor , Holmer Rens , Jahn Katharin , Jessurun Lobo Thamar , Keizer Emma M , Khatri Indu , Kiełbasa Szymon M , Korbel Jan O , Kozlov Alexey M , Kuo Tzu-Hao , Lelieveldt Boudewijn PF , Mandoiu Ion I , Marioni John C , Marschall Tobias , Mölder Felix , Niknejad Amir , Rączkowski Łukasz , Reinders Marcel , de Ridder Jeroen , Saliba Antoine-Emmanuel , Somarakis Antonios , Stegle Oliver , Theis Fabian J , Yang Huan , Zelikovsky Alex , McHardy Alice C , Raphael Benjamin J , Shah Sohrab P , Schönhuth Alexander 
Published: August 2019

The recent upswing of microfluidics and combinatorial indexing strategies, further enhanced by very low sequencing costs, have turned single cell sequencing into an empowering technology; analyzing thousands—or even millions—of cells per experimental run is becoming a routine assignment in laboratories worldwide. As a consequence, we are witnessing a data revolution in single cell biology. Although some issues are similar in spirit to those experienced in bulk sequencing, many of the emerging data science problems are unique to single cell analysis; together, they give rise to the new realm of 'Single Cell Data Science'.
Here, we outline twelve challenges that will be central in bringing this new field forward. For each challenge, the current state of the art in terms of prior work is reviewed, and open problems are formulated, with an emphasis on the research goals that motivate them.
This compendium is meant to serve as a guideline for established researchers, newcomers and students alike, highlighting interesting and rewarding problems in 'Single Cell Data Science' for the coming years.
Muscle quality index and isometric strength in older adults with hip osteoarthritis
Authors: Jerez-Mayorga Daniel , Chirosa Ríos Luis Javier , Reyes Alvaro , Delgado-Floody Pedro , Machado Payer Ramon , Guisado Requena Isabel María 
Published: August 2019

Background
Older adults with hip osteoarthritis (OA) suffer a progressive loss of muscle quality and strength, affecting their daily activities and quality of life. The purpose of this study is to compare the levels of isometric strength among older adults with and without hip OA and healthy young adults, and to determine the relationship between muscle quality index (MQI) and isometric strength.

Methods
Fourteen subjects with hip OA (65.6 ± 3.0 years), 18 healthy older adults (66.6 ± 6.5 years) and 32 young adults (20.7 ± 2.0 years) participated in the study. MQI, isometric muscle strength of the hip, ten time sit-to-stand tests, and body composition were measured.

Results
The MQI was lower in subjects with hip OA, with no significant differences between groups (p > 0.054). Subjects with OA produced significantly less isometric strength in hip extension (p < 0.001), flexion (p < 0.001), abduction (p < 0.05), adduction (p < 0.001), external (p < 0.05) and internal rotation (p < 0.05). Subjects with OA demonstrated longer time in the execution of the sit-to-stand test (p < 0.001) in comparison with healthy older and young adults. High correlations between MQI, sit-to-stand (r = − 0.76, p < 0.01) and peak force during hip abduction (r = 0.78, p < 0.01) where found in subjects with OA. Moderate correlation between MQI and peak force during hip flexion (r = 0.55, p < 0.05) and external rotation (r = 0.61, p < 0.05) were found in the OA group.

Conclusions
Subjects with OA have lower MQI than old and young healthy controls. In subjects with OA, there was a significant relationship between isometric strength of hip muscles and performance on the sit-to-stand test and the MQI.
Accessibility of Agroforestry Farmers to Credit Facilities on Poultry Egg Production in Oyo State, Nigeria
Authors: Aderounmu A. F. , Oyewo I. O. 
Published: August 2019

Poultry egg production is an economically viable investment among Agroforestry farmers in Southwestern Nigeria but paucity of funds and high cost of inputs are major problems in their business operations. This study focused on the effects of accessibility and non-accessibility of Agroforestry farmers to credit on poultry egg production. Data were randomly collected from 120 poultry farmers with a structured questionnaire which comprised of 60 credit beneficiaries (CB) and 60 non-credit beneficiaries (NCB) Agroforestry farmers. The data were analyzed with mean, percentages, frequency distribution, logit and multiple regression analyses. The results of the analyses indicated that the mean age of the CB and NCB Agroforestry farmers were ±46 and ±56 years respectively. Majority of the farmers were married CB (77.4%) and NCB (81.0%). The logit regression analysis revealed that the age of the respondents had a positive relationship with access to credit at 5% level of significance. Multiple regression model for credit accessed farmers indicated that age, family size, drug quantity are positively related to output and are significant at 10% and 1% levels. Multiple regression result for NCB farmers shows that the quantity of drug used is positively related to the egg output at 1% level. The hypotheses tested show that there was a significant relationship between socio-economic characteristics and the egg production in the study area and; between the output of farmers who are credit beneficiaries and non-credit beneficiaries. The major constraints to poultry production in Agroforestry system were limited finances, high cost of inputs and poor quality of day old chicks. Accessibility to formal credit facilities has a key role to play in Agroforestry poultry farming. Individuals, Governments and NGOs should therefore facilitate empowerment of youths in poultry egg production.
Determination of Selected Heavy Metals in Tobacco Tree Shrubs Growing around Dandora Dumpsite, Nairobi, Kenya
Authors: Kahara P. M. , Murungi J. , Kiptoo J. K. , Nyaga G. 
Published: August 2019

Environmental pollution by heavy metals is presently a serious threat to public health. Despite the toxic contaminants contained in municipal waste, most of the dumpsites remain unregulated and uncontrolled. The objective of this study was to determine the levels of Pb, Cr and Cd in the leaves of tobacco tree plants growing around the dumpsite so as to assess their impact on the environment. The pseudo-total concentration of the metals in the soil was done so as to calculate the transfer factors.pH and total organic carbon (TOC) of the soil was also determined. Soil and plant samples were collected thrice from thirty two sampling sites along the off-loading path from the centre of Dandora dumpsite up to a distance of 700 m away from the centre at depth of 0-30cm (top soil). Metal analysis was done using flame atomic absorption spectroscopy (FAAS). Pb levels ranged from 7.58±0.34 to 16.57±0.79 µg/g in the washed leaves and 9.22±0.36 to 19.27±0.40 µg/g in the unwashed leaves. Cr levels ranged from 5.11±0.40 to 14.4±0.91 µg/g in the washed leaves and 5.01±0.45 to 15.50±0.40 µg/g in the unwashed leaves. While Cd levels ranged from 0.24±0.01 to 3.62 ±0.17 µg/g in the washed leaves and 0.37±0.02 to 3.68±0.25 µg/g in the unwashed leaves. All these levels were above World Health Organization recommended limits in plants of Pb (0.3 µg/g), Cr (3 µg/g) and Cd (0.2 µg/g). Pearson correlation of the levels in the plants with their concentrations in the soils gave significantly positive values. This suggest that high metal concentration in the soil leads to increased mobility and hence bioavailability. Results obtained therefore suggest that Dandora dumpsite is highly polluted and people should be discouraged from using waste from the dumpsite as manure.
Efficacy of Two (2) Organic Fertilizer Sources (Oil Palm Bunch and Vermicast) on the Growth Response of Tetrapleura tetraptera
Authors: Aderounmu A. F. , Musa F. B. 
Published: August 2019

To increase awareness of Tetrapleura tetraptera potential uses, enhance its utilization and promote its domestication as a fruit trees, a potential use of organic manure as soil amendment in afforestation, reforestation, agroforestry, fruit tree orchards, and bio-energy plantations cannot be over emphasized. Therefore, the study to determine the efficacy of organic manure (sole application and its interaction) on the growth of Tetrapleura tetraptera under a screen house condition was carried out in Federal College of Forest, Ibadan located within the government Reserve Area (GRA) Jericho Ibadan. The experimental design was a 2 x 8 factorial arranged in a Completely Randomized Design (CRD) with seven (7) replicates each making a total of 112 experimental samples. The treatments used were as follows: vermicast at two levels (20t/ha, 40t/ha), oil palm bunch at two levels (20t/ha, 40t/ha), interaction of vermicast and oil palm bunch (1:1, 1:2 and 2:1) and Control (no amendment). Data on plant height number of leaves, collar diameter and dry matter yields were generated and subjected to analysis of variance and significant means separated using Duncan’s Multiple Range Test at 5 % level of significance. The results shows that, the collar diameter of Tetrapleura tetraptera increased (P=0.05) with the sole application of oil palm bunch at 40t/ha with a mean value of 2.16mm , however, this increase can also be comparable to the sole application of oil palm bunch at 20t/ha with a mean value of 2.04 mm. Oil palm bunch at 20t/ha recorded the highest plant of Tetrapleura tetraptera with a mean value of 18.00 cm while the interaction of VC+OB (2:1) and VC 40t/ha are also relatively comparable to the control (no amendment) to improve the plant height. The highest leaves number was observed when oil palm bunch 20t/ha was used as an amendment with a mean value of 14.0 while the lowest number of leaves was recorded with the interaction VC+OB 1:1 with a mean value of 12.0. From the results obtained, oil palm bunch residue as an organic fertilizer improves the growth of Tetrapleura tetraptera.
Biomimetic and Radially Symmetric Graphene Aerogel for Flexible Electronics
Authors: Gao Libo , Fan Rong , Zhou Wenzhao , Hu Xinkang , Cao Ke , Wang Weidong , Lu Yang 
Published: August 2019

AbstractDeveloping a generalized route to effectively fabricate periodic mechanically flexible graphene aerogels across several size orders and whole structural integrity on a large scale for flexible electronics is still a challenge. Herein, inspired by bamboo's natural hierarchical structure, a general method is developed to effectively fabricate biomimetic cellular graphene fibers using hydrogen bubbles and ice simultaneously as templates, whose whole size ranges from micro to several centimeters. Owing to its superior mechanical flexibility demonstrated by the in situ scanning electron microscope test and intrinsically good electrical conductivity, its potential in flexible electronics such as sensors, supercapacitors, and Ni–Zn batteries is carefully investigated. It not only shows superior sensitivity in the monitoring of the pulse pressure in sensor devices but also directly serves as a promising binder, flexible scaffold, and conductive additive, as well as extra active material in the energy storage device without any extra additives. This strategy can also be extended to fabricate other configurations of graphene aerogels such as spring‐like type and bulk film, able to serve as the next generation of intelligent infrastructure for achieving multifunctional structural and functional tasks.
Understanding the Role of Oxygen Vacancy in Visible–Near‐Infrared‐Light‐Absorbing Ferroelectric Perovskite Oxides Created by Off‐Stoichiometry
Authors: Xiao Hongyuan , Wang Yufeng , Jiao Nan , Guo Yiping , Dong Wen , Zhou Hua , Li Qian , Sun Chengjun 
Published: August 2019

AbstractRecently, the visible or even‐to‐near‐infrared light absorbing perovskite ABO3 solid state solutions, show promising application in solar cells and multienergy harvesters or sensors by simultaneously introducing transition metal and oxygen vacancies. However, the existence of oxygen vacancies fundamentally causes photoexcited carrier trapping and large leakage current. Therefore, it is still challenging to limit oxygen vacancies while maintaining low bandgap and high ferroelectricity. Here, an efficient charge compensation strategy by finely adjusting the ion ratio on the A‐site to obtain an oxygen‐vacancy‐free relaxer ferroelectric is demonstrated in the system of Nax
Biy
TiO3‐BaTi0.5Ni0.5O3, where y > x. It is found that the oxygen‐vacancy‐free composition still yields strong visible–near‐infrared‐light‐absorbing and enhanced photoresponse, in which the photocurrent density doubles from ≈0.16 to ≈0.32 μA cm−2. A new bandgap tuning mechanism is proposed according to the local structural information of Ni ions obtained via extended X‐ray absorption fine structure. Moreover, this work succeeds in establishing the relationship between the concentration of oxygen vacancies and ferroelectric/piezoelectric properties of Nax
Biy
TiO3‐BaTi0.5Ni0.5O3. This research points out a promising route to the material design of bandgap engineered ferroelectrics with controlled defects, which is expected to benefit a wide range of functional energy conversion devices.
Process boundaries of collision welding at low energies
Authors: Groche P. , Niessen B. , Pabst C. 
Published: August 2019

AbstractCollison welding is a promising material‐closed joining process that enables bonds with various advantages. It is already used as explosion welding to produce clad materials that cannot be joined otherwise. Other collision welding processes as electromagnetic pulse welding do not contain that amount of energy, but they can be used in mass production. In order to achieve a high process and product reliability, the process has to be designed accurately. But the process boundaries are not yet completely understood. In this paper, process windows for aluminium and copper joints, produced by a model test rig, are compared. Additionally, high speed observation and micro sections are used to enhance the knowledge about process boundaries and the influence of the jet.
Association of single nucleotide polymorphisms of miRNAs involved in the GLUT4 pathway in T2DM in a Chinese population
Authors: Li Yiping , Li Chuanyin , Yang Man , Shi Li , Tao Wenyu , Shen Keyu , Li Xianli , Wang Xiaoling , Yang Ying , Yao Yufeng 
Published: August 2019

AbstractBackgroundThe insulin/insulin receptor substrate (IRS)/phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt)/GLUT4 pathway plays a crucial role in insulin resistance and is closely associated with T2DM. Accumulating evidence indicates that miRNAs (such as miR‐135a, let‐7d, miR‐107, miR‐96, miR‐29a, miR‐23a, miR‐126, miR‐133a, and miR‐106b) influence the GLUT4 pathway.MethodsA total of 784 subjects with T2DM and 846 nondiabetic subjects were enrolled and 12 single nucleotide polymorphisms (SNPs) in miRNAs (rs10459194 in miR‐135a‐2, rs10993081 and rs7045890 in let‐7d, rs2296616 in miR‐107, rs2402959 and rs6965643 in miR‐96, rs24168 in miR‐29a, rs3745453 in miR‐23a, rs4636297 in miR‐126, rs8089787 and rs9948906 in miR‐133a‐1 and rs999885 in miR‐106b) involved in the GLUT4 pathway were genotyped using the MassArray method in a Chinese population.ResultsOur data showed that the A allele of rs2402959 in miR‐96 may increase the risk of developing T2DM (p = .002, OR = 1.266; 95% CI: 1.089–1.471). The genotypes of rs3745453 in miR‐23a showed the difference between T2DM and control groups (p < .001). Moreover, for rs2402959, compared with the A/A genotype, the (G/A–G/G) genotype shows a protective effect in T2DM (p = .001, OR = 0.71; 95% CI: 0.58–0.87). For rs3745453, compared with the (A/A–A/G) genotype, the G/G genotype increases the risk of T2DM (p < .001, OR = 1.95; 95% CI: 1.38–2.77). In addition, we also found that rs4636297G/G genotype was associated with lower TC in T2DM group.ConclusionOur results revealed that genetic variations in the miRNAs involved in the GLUT4 pathway were associated with T2DM susceptibility in a Chinese population, and these results emphasize the need to study the functional effects of these variations in the miRNAs involved in the GLUT4 pathway on the risk of developing T2DM.
A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways
Authors: Hou Yue , Zhang Yuchen , Mi Yan , Wang Jian , Zhang Haotian , Xu Jikai , Yang Yanqiu , Liu Jingyu , Ding Lingling , Yang Jingyu , Chen Guoliang , Wu Chunfu 
Published: August 2019

ScopeThe anti‐neuroinflammatory effect of a novel quinolyl‐substituted analogue of resveratrol (RV01) on lipopolysaccharide (LPS)‐induced microglial activation is investigated, as well as the possible underlying mechanisms.Methods and resultsCell viability is measured using an MTT assay. Nitric oxide (NO) release is determined by nitrite assay. The interaction between RV01 and inducible nitric oxide synthase (iNOS) is studied using molecular docking. Free radical scavenging activity and reactive oxygen species (ROS) production are determined by DPPH reduction assay and DCFH‐DA assay. Pretreatment with RV01 (1–30 µm) prior to LPS (1 µg mL–1) stimulation decreased NO release and iNOS expression without observable cytotoxicity. RV01 reduced the mRNA levels and secretion of tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6). RV01 also inhibited LPS‐induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. Furthermore, RV01 decreases the protein expression of toll‐like receptor 4 (TLR4) and inhibits the LPS‐induced activation of the mitogen‐activated protein kinase (MAPK) and nuclear transcription factor‐κB (NF‐κB) signaling pathways. Additionally, conditioned medium from microglia co‐treated with LPS and RV01 alleviates the death of SH‐SY5Y cells induced by conditioned medium from activated N9 microglial cells. Lastly, a mouse neuroinflammation model is further used to confirm the effect of RV01 in vivo.ConclusionThese results show that RV01 suppresses microglia‐mediated neuroinflammation and protects neurons from inflammatory damage, which indicates that RV01 has great potential as a nutritional preventive strategy for neuroinflammation‐related diseases.
Caring for a stroke patient: The burden and experiences of primary caregivers in Uganda – A qualitative study
Authors: Gertrude Namale , Kawuma Rachel , Nalukenge Winifred , Kamacooko Onesmus , Yperzeele Laetitia , Cras Patrick , Ddumba Edward , Newton Robert , Seeley Janet 
Published: August 2019

AbstractAimWe assessed the burden and experiences of caregivers looking after stroke patients in Kampala, Uganda.DesignWe conducted a qualitative cross‐sectional study between May 2018–July 2018 among primary caregivers of stroke patients.MethodsThe primary caregiver was defined as the person spending most of the time providing daily care for the stroke patient for at least four months. Purposive sampling was used to consecutively recruit the primary caregivers. In‐depth interviews were conducted, and audiotape recorded, and observations were also made. Data were managed using NVIVO 12.0 following thematic approach.ResultsTwenty‐five caregivers were included in the analysis with a mean age of 39.3, SD 10.7. Four themes were identified from the qualitative analysis on caregivers’ experiences of looking after stroke patients: taking on new responsibilities, factors that protected caregivers from breaking down, limited resources and experiences with patient outcomes. Our findings highlight the need for interventions to support stroke patients and their caregivers.