bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromuscular Involvement in Glycogen Storage Disease Type III in Fifty Tunisian Patients: Phenotype and Natural History in Young Patients
Authors: Ben Messaoud Sana , Ben Abdelaziz Rim , Ben Ali Nadia , Boudabous Hela , Ben Abdelaziz Ines , Ben Ameur Zeineb , Sassi Yosra , Kaabachi Neziha , Abdelhak Sonia , Abdelmoula Mohamed , Fradj Mohamed , Azzouz Hatem , Tebib Neji , Ben Chehida Amel 
Published: October 2018

Background Our aim was to describe the natural history of neuromuscular involvement (NMI) in glycogen storage disease type III (GSDIII).
Methods We conducted a longitudinal study of 50 Tunisian patients, 9.87 years old in average.
Results NMI was diagnosed at an average age of 2.66 years and was clinically overt in 85% of patients. Patients with clinical features were older (p = 0.001). Complaints were dominated by exercise intolerance (80%), noticed at 5.33 years in average. Physical signs, observed at 6.75 years in average, were dominated by muscle weakness (62%). Functional impairment was observed in 64% of patients, without any link with age (p = 0.255). Among 33 patients, 7 improved. Creatine kinase (CK) and aspartate aminotransferase (AST) levels were higher with age.Electrophysiological abnormalities, diagnosed in average at 6.5 years, were more frequent after the first decade (p = 0.0005). Myogenic pattern was predominant (42%). Nerve conduction velocities were slow in two patients. Lower caloric intake was associated with more frequent clinical and electrophysiological features. Higher protein intake was related to fewer complaints and physical anomalies.
Conclusion Neuromuscular investigation is warranted even in asymptomatic patients, as early as the diagnosis of GSDIII is suspected. Muscle involvement can be disabling even in children. Favorable evolution is possible in case of optimal diet.
Personality Traits of Postmenopausal Women with Sexual Dysfunction
Authors: de Caires Cristiano Santos , Steiner Marcelo Luis , Pompei Luciano de Melo , Strufaldi Rodolfo , Fernandes Cesar Eduardo 
Published: October 2018

Objective The aim of the present study is to identify the association between personality traits of postmenopausal women and the occurrence of sexual dysfunction.
Methods A total of 43 postmenopausal women were evaluated according to their self-perception of the quality of their sexual life. They answered the following questionnaires: Sociodemographic Profile Questionnaire, Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI) and Factorial Personality Inventory (FPI-II).
Results Women with poorer sexual self-perception showed low affective need (p < 0.01) and low need for organization (p < 0.01). Based on the need for control and opposition, there was no difference between the groups. Groups separated by the scores obtained on the FSFI showed no significant differences.
Conclusion Postmenopausal women with lower schooling and personality characteristics that demonstrate low affective and organizational needs are more likely to present sexual dysfunction.
Nematic twist–bend phase in an external field
Authors: Pająk Grzegorz , Longa Lech , Chrzanowska Agnieszka 
Published: October 2018

SignificanceThe twist–bend nematic liquid crystalline phase is the fifth nematic structure recognized in nature [Chen D, et al. (2013)Proc Natl Acad Sci USA110:15931–15936], and its stabilization is explained by assuming a coupling between polar and nematic orderings. It exhibits macroscopically chiral heliconical orientational order on the 10-nm scale and represents a unique example of spontaneous chiral symmetry breaking for a system of achiral molecules. Understanding how an external field affects the stability of this phase can shed further light on the origin of this induced twist and is of relevance to potential applications. Within the Landau–de Gennes theory we find that for compounds with positive anisotropy the helix unwinds to a polar nematic, however negative material anisotropy gives rise to a rich sequence of new nematic phases obtained via a mechanism of flattening the conical spiral.
A Multicenter, Retrospective Evaluation of Tissue Stabilized-Guided Subcision in the Management of Cellulite
Authors: Nikolis Andreas , Enright Kaitlyn M , Sapra Sheetal , Khanna Julie 
Published: October 2018

Abstract

Background
The first FDA-cleared, long-lasting, minimally invasive device for improving the appearance of cellulite was recently launched in Canada as a novel, tissue stabilized–guided subcision (TS-GS) system (Cellfina, Merz North America, Inc., Raleigh, NC). Clinicians from 2 of the first Canadian sites offering this procedure were interested in evaluating treatment efficacy and patient satisfaction after its first year on the market.

Objectives
The authors sought to evaluate the efficacy of TS-GS and the level of patient satisfaction associated with the procedure.

Methods
Medical charts of female patients treated with the TS-GS system in 2017 were retrospectively analyzed at 2 Canadian centers. Measurements at baseline and 3 months posttreatment were assessed for patient satisfaction and physician-rated efficacy. Patient satisfaction was assessed using a 5-point Likert-type scale, and efficacy was evaluated through physician review of 2-deminsional and 3-dimensional photography, the Nürnberger-Müller Scale for cellulite, and the Global Assessment of Improvement Scale.

Results
We reviewed 25 patient charts. At month 3, 95.6% of patients were satisfied with treatment results and physician evaluations revealed that on average, patients displayed a 1-point improvement in their cellulite grades. Moreover, Global Assessment of Improvement Scale scores indicated that all patients had visible improvement in the global appearance of cellulite. No serious adverse events were observed within 3 months postprocedure.

Conclusions
The physician ratings, patient satisfaction, and photographic evidence support the efficacy of the TS-GS system to manage grades 1 to 3 cellulite in women’s thighs and buttocks. These findings indicate the safety of the TS-GS system.

Level of Evidence: 4
Intervision and Professional Development: An Exploration of a Peer-Group Reflection Method in Social Work Education
Authors: Staempfli Adi , Fairtlough Anna 
Published: October 2018

Abstract‘Intervision’, a peer-led group reflection method, was introduced in a teaching partnership between a university and three local authorities to enhance the quality of social work education and support the development of a learning culture across the partnership. A review of the limited international research on Intervision shows almost entirely positive impacts but no studies in social work education. This article reports on research into impacts following the introduction of Intervision sessions for BA (bachelor’s) and MA (master’s) social work students. An interpretive, qualitative approach with thematic data analysis of two focus groups with twenty-three participants was carried out. Findings show that, for most students, Intervision offered emotional containment, widened their perspectives and enhanced skills for Intervision. Students identified several positive impacts on their professional development and practice. Reported factors that contributed to students’ varied experience of Intervision sessions and their impact were commitment among participants and facilitators’ ability to model the Intervision process. The context of the teaching partnership was crucial in supporting students to negotiate their learning at the boundary between practice and university. Based on these findings, Intervision is suggested as a useful approach to embed peer-led reflective practice, and open questions for further research are suggested.
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice
Authors: Kosinsky Robyn Laura , Chua Robert Lorenz , Qui Martin , Saul Dominik , Mehlich Dawid , Ströbel Philipp , Schildhaus Hans-Ulrich , Wegwitz Florian , Faubion William A , Johnsen Steven A 
Published: October 2018

AbstractBackground and AimsInflammatory bowel diseases are linked to an increased risk of developing colorectal cancer [CRC]. Previous studies suggested that the H2B ubiquitin ligase RING finger protein-20 [RNF20] inhibited inflammatory signaling mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB]. However, the role of RNF40, the obligate heterodimeric partner of RNF20, in the context of inflammation and CRC has not been addressed. Here, we examined the effect of RNF40 loss on CRC cells in vitro and on inflammation and inflammatory signaling in vitro and in vivo.MethodsWe evaluated H2Bub1 levels in human and murine colorectal tumors by immunohistochemistry. Moreover, we correlated H2Bub1 and RNF40 levels in vivo and assessed the consequences of RNF40 depletion on cellular phenotype and gene expression in CRC cells in vitro. Finally, we examined the effect of a colon-specific loss of Rnf40 in a murine model of colitis, and assessed both local and systemic inflammation-associated consequences.ResultsIn vitro studies revealed that the tumorigenic phenotype of CRC cells decreased after RNF40 depletion and displayed gene expression changes related to chromosome segregation and DNA replication, as well as decreased induction of several NF-κB-associated cytokines. This effect was associated with decreased nuclear localization of NF-κB following tumor necrosis factor alpha treatment. Consistently, the colon-specific loss of Rnf40 exerted a protective local, as well as systemic, effect following acute colitis.ConclusionsOur findings suggest that RNF40 plays a central role in the maintenance of tumorigenic features and inflammatory signaling by promoting nuclear NF-κB activity.
The Affective Border: Missing Migrants and The Governance of Migrant Bodies at The EU’s Southern Frontier
Authors: Robins Simon 
Published: October 2018

Abstract
While living migrants are the object of enormous attention, counted and screened on arrival and throughout their presence in European states, those who die crossing the Mediterranean remain uncounted and largely unidentified, as a result of a failure of European states to collect data from both bodies and from families looking for missing loved ones. Living migrants are seen as objects of interest to and control of biopolitical regimes, yet, once migrants are dead, they become marginal to their concerns. The body of the migrant is neither fully inside nor outside the social and legal order, while family members waiting for news of a loved one are entirely invisible to it. The result of death at the frontier is that the border gains an affective dimension, with the capacity to communicate trauma over large distances, plunging into ambiguity families in states of migrant origin who are unable to learn if loved ones are alive or dead.
Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function
Authors: Naik Abhijit S , Afshinnia Farsad , Aqeel Jawad , Cibrik Diane M , Samaniego Milagros , Wickman Larysa , Wang Su Q , Chowdhury Mahboob , Wiggins Roger C 
Published: October 2018

Abstract

Background
Kidney allograft half-life has not improved despite excellent short-term survival. Recent long-term surveillance biopsy studies identify accumulating glomerulosclerosis (GS) to be associated with late allograft loss. While podocyte depletion is well known to drive proteinuria and GS in animal models and human glomerular diseases, its role in renal allograft loss of function is generally not recognized.

Methods
To address these questions, we collected urine from 125 kidney allograft recipients in the first posttransplant year for urine pellet messenger RNA (mRNA) and protein analysis, with a median follow up of 4.5 years.

Results
Using multivariable linear models adjusted for proteinuria, transplant, recipient and donor factors, we observed that the average urine pellet podocin mRNA normalized to urine creatinine (UPodCR) in the first posttransplant year was significantly associated with an estimated glomerular filtration rate (eGFR) decline (P = 0.001). The relationship between UPodCR and eGFR decline persisted even among recipients who were nonproteinuric and who had no recurrent or de novo glomerular disease identified on 1-year protocol biopsy. Finally, we identified recipient, donor and recipient:donor body surface area mismatch ratio to be independently associated with UPodCR early after transplantation. A larger donor was protective, while a larger recipient and increased recipient:donor size mismatch ratio were associated with increased UPodCR.

Conclusions
These findings support the concept that in kidney allografts, accelerated podocyte loss precedes proteinuria and is associated with inferior long-term allograft outcomes as measured by eGFR decline and may be initiated by recipient:donor size mismatch. Modulating factors driving early podocyte detachment after kidney transplantation may help improve long-term outcomes.
Influence of chromium propionate dose and feeding regimen on growth performance and carcass composition of pigs housed in a commercial environment1,2
Authors: Gebhardt Jordan T , Woodworth Jason C , Tokach Mike D , DeRouchey Joel M , Goodband Robert D , Loughmiller Joe A , de Souza Ana L P , Dritz Steve S 
Published: October 2018

Abstract
Although chromium (Cr) feeding study results have been variable, our hypothesis was feeding a regimen that changed dosage over time would result in a larger positive response in growth performance and carcass characteristics. In Exp. 1, a total of 1,206 pigs (PIC 337 × 1050, initial BW 28.7 kg) were used with 27 pigs per pen and 9 pens per treatment. Diets were corn–soybean meal-dried distillers grains with solubles based and were fed in a five-phase feeding program. Treatments were arranged as a 2 × 2 + 1 factorial with a control diet containing no added Cr propionate (Kemin Industries Inc., Des Moines, IA), or diets with either 100 or 200 µg/kg added Cr during the grower (dietary phases 1 and 2) and/or finisher (dietary phases 3, 4, and 5) periods. During the grower period, ADG and G:F were similar among pigs fed the control or 100 µg/kg added Cr diets, but decreased in pigs fed 200 µg/kg Cr (quadratic, P ≤ 0.001). During the finisher period, pigs supplemented with 200 µg/kg added Cr had the greatest ADG and G:F (quadratic, P ≤ 0.019). Overall, increasing Cr had no effect on ADG or ADFI; but G:F was greatest (quadratic, P = 0.020) when pigs were fed 100 µg/kg of added Cr throughout. Carcass characteristics were not influenced by Cr dosage or feeding regimen. In Exp. 2, a total of 1,206 pigs (PIC 359 × 1050, initial BW 48.9 kg) were used with 27 pigs per pen and 15 pens per treatment. Diets were corn–soybean meal, dried distillers grains with solubles based and were fed in four phases. There were three dietary treatments: a diet with no added Cr for both grower (dietary phase 1 and 2) and finisher (dietary phase 3 and 4) periods, a diet with 200 µg/kg added Cr during the grower and 100 µg/kg added Cr during the finisher periods, or a diet with 200 µg/kg added Cr for both periods. Addition of 200 µg/kg Cr in both periods marginally increased (P &lt; 0.10) ADG compared with pigs fed no added Cr. There was no evidence (P ≥ 0.523) of added Cr influencing overall ADFI and G:F. Percentage carcass yield was reduced (P = 0.018) when Cr was added at 200 µg/kg for both periods, with no evidence of differences (P ≥ 0.206) in other carcass characteristics. In summary, overall G:F was improved in Exp. 1, and ADG in Exp. 2, by added Cr, but there was no evidence that different feeding regimens will consistently result in improved performance. However, these data are consistent with the literature in that added Cr in growing-finishing pigs diets improves, albeit small, ADG or G:F.
Thoracic Epidural Analgesia: Does It Enhance Recovery?
Authors: Rosen David R. , Wolfe Rachel C. , Damle Aneel , Atallah Chady , Chapman William C. , Vetter Joel M. , Mutch Matthew G. , Hunt Steven R. , Glasgow Sean C. , Wise Paul E. , Smith Radhika K. , Silviera Matthew L. 
Published: October 2018

BACKGROUND:
Thoracic epidural analgesia has been shown to be an effective method of pain control. The utility of epidural analgesia as part of an enhanced recovery after surgery protocol is debatable.

OBJECTIVE:
This study aimed to determine if the use of thoracic epidural analgesia in an enhanced recovery after surgery protocol decreases hospital length of stay or inpatient opioid consumption after elective colorectal resection.

DESIGN:
This is a single-institution retrospective cohort study.

SETTINGS:
The study was performed at a high-volume, tertiary care center in the Midwest. An institutional database was used to identify patients.

PATIENTS:
All patients undergoing elective transabdominal colon or rectal resection by board-certified colon and rectal surgeons from 2013 to 2017 were included.

MAIN OUTCOME MEASURES:
The main outcome was length of stay. The secondary outcome was oral morphine milligram equivalents consumed during the first 48 hours.

RESULTS:
There were 1006 patients (n = 815 epidural, 191 no epidural) included. All patients received multimodal analgesia with opioid-sparing agents. Univariate analysis demonstrated no difference in length of stay between those who received thoracic epidural analgesia and those who did not (median, 4 vs 5 days; p = 0.16), which was substantiated by multivariable linear regression. Subgroup analysis showed that the addition of epidural analgesia resulted in no difference in length of stay regardless of an open (n = 362; p = 0.66) or minimally invasive (n = 644; p = 0.46) approach. Opioid consumption data were available after 2015 (n = 497 patients). Univariate analysis demonstrated no difference in morphine milligram equivalents consumed in the first 48 hours between patients who received epidural analgesia and those who did not (median, 135 vs 110 oral morphine milligram equivalents; p = 0.35). This was also confirmed by multivariable linear regression.

LIMITATIONS:
The retrospective observational design was a limitation of this study.

CONCLUSION:
The use of thoracic epidural analgesia within an enhanced recovery after surgery protocol was not found to be associated with a reduction in length of stay or morphine milligram equivalents consumed within the first 48 hours. We cannot recommend routine use of thoracic epidural analgesia within enhanced recovery after surgery protocols. See Video Abstract at http://links.lww.com/DCR/A765.
Examining Medical Office Owners and Clinicians Perceptions on Patient Safety Climate
Authors: Mazurenko Olena , Richter Jason , Kazley Abby Swanson , Ford Eric 
Published: October 2018

Objective
An essential element of effective medical practice management is having a shared set of beliefs among members regarding patient safety climate. Recognizing the need for improving patient safety, the Agency for Healthcare Research and Quality began a series of surveys to assess medical practice members’ attitudes and beliefs on patient safety climate. The aim of the study was to examine owners and clinicians perceptions of their medical practice’s patient safety climate.

Methods
We used the 2010–2011 Medical Office Survey on Patient Safety Culture collected by the Agency for Healthcare Research and Quality. We used hierarchical linear modeling to examine owners’ and clinicians’ perceptions of practice’s patient safety climate while controlling for the nested nature of individuals within practices.

Results
Managers with ownership responsibility, clinicians with ownership responsibility, and staff clinicians have different perceptions of the practice’s patient safety climate. In particular, managers with ownership responsibility have more positive perceptions of the patient safety climate, as compared with non-owners. Clinicians with ownership responsibility had less favorable views than managers in a similar role. Finally, staff clinicians have the most negative perceptions of patient safety climate as compared with individuals in the ownership positions.

Conclusions
There is a statistically significant lack of agreement among medical office team members depending on their backgrounds and roles. Increasing the communication among organizational members about their practice’s patient safety climate is a principal aim whether improvements in care quality are to be achieved.
Implant Based Breast Reconstruction With Acellular Dermal Matrix
Authors: Lohmander Fredrik , Lagergren Jakob , Roy Pankaj G. , Johansson Hemming , Brandberg Yvonne , Eriksen Catharina , Frisell Jan 
Published: October 2018

Objective:
To evaluate clinical outcomes of using acellular dermal matrix (ADM) with implant based breast reconstructions (IBBRs) in a randomized controlled trial.

Summary Background Data:
The use of ADMs in IBBRs is widespread, but link between ADM and complications remain a controversial topic. In view of reports concerning harm, we present 6-months safety data of ADM-assisted IBBR in the setting of breast cancer treatment.

Methods:
An open-label, randomized, controlled trial recruiting patients from 4 centers in Sweden and 1 in UK. Eligible were women with breast cancer planned for mastectomy with immediate IBBR. Participants were randomly allocated to IBBR with or without ADM (Strattice, Branchburg, NJ), with stratification by center in blocks of 6. Main primary endpoint was number of unplanned reoperations at 24 months, and safety expressed as the incidence of adverse events with a 6-month follow-up time for all participants. Analysis were done per protocol using Fisher exact test for complications and reoperations.

Results:
From start of enrolment on April 24, 2014, to close of trial on May 10, 2017, 135 women were enrolled, of whom 64 with ADM and 65 without ADM were included in the final analysis. Four patients (6%) in each group had reconstructive failure with implant loss, but IBBR with ADM exhibited a trend of more overall complications and reoperations (difference 0·16, 95% CI, −0·01 to 0·32, P = 0·070), and with higher risk of wound healing problems (P = 0·013).

Conclusions:
With 6-months follow-up for all participants, immediate IBBR with ADM carried a risk of implant loss equal to conventional IBBR without ADM, but was associated with more adverse outcomes requiring surgical intervention. Further investigation of risk factors and patient selection in a long-term follow-up is warranted.