bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Impairment and Refractive Error Among Deaf and Hard of Hearing Learners in Ghana
Authors: Kwarteng Michael Agyemang , Mashige Khathutshelo Percy , Kyei Samuel , Dogbe Daniel Sunkwa Quarcoo , Govender-Poonsamy Pirindhavellie , Asomani Collins , Kwarteng Dominic , Hayford-Mbrah Gershon , Berchie Mercy Oforiwaa , Kwarteng Maame Kyerewaa Darko 
Published: November 2024

Introduction This study aims to assess the prevalence of visual impairment and refractive error among learners who are deaf or hard of hearing in schools for Deaf students in Ghana. Methods A descriptive cross-sectional study design was used to assess the distance visual acuity with the logMAR “E” chart, and ocular health was assessed with an ophthalmoscope and handheld slit lamp with a 90 D lens. Results A total of 1,914 learners were examined in six schools for Deaf students in Ghana. Their ages ranged from 5 to 43 years ( M = 15.18 ± 4.53 years). There were more males (55.5%) than females (44.5%) in the study. Among the learners, 91.1% were deaf, followed by mild hard of hearing (4.0%) and profound hard of hearing (1.8%), among others. Also, 94.8% of the learners had typical vision, followed by moderate visual impairment (2.5%), mild visual impairment (1.4%), and blindness (1.3%) before the provision of spectacles. There was no association between visual impairment (i.e., blindness and visual impairment) and sex among the learners ( p < .05). The leading causes of visual impairments were refractive error and cataracts, while the leading cause of ocular morbidity was allergic conjunctivitis. The prevalence of visual impairment was reduced by almost 2-fold after the provision of spectacles. Discussion The prevalence of deafblindness was low among the learners, with uncorrected refractive errors as the leading cause of mild and moderate visual impairment. If these learners had not been identified through this study, they would have continued to struggle to access the curriculum visually. Implications for Practitioners There is a need to assess hearing and visual functions among learners with disabilities in developing countries like Ghana.
Association Between Wound Healing and the Japanese Below-the-Knee Chronic Total Occlusion Score in Patients With Chronic Limb-Threatening Ischemia After Endovascular Therapy
Authors: Fukagawa Tomoya , Mori Shinsuke , Yamawaki Masahiro , Kobayashi Norihiro , Ito Yoshiaki 
Published: November 2024

Introduction: In the current study, we hypothesized that the Japanese below-the-knee chronic total occlusion score could be used to stratify the lesion difficulty of endovascular therapy for below-the-knee chronic total occlusion through angiographic evaluation. We thus aimed to evaluate the prognostic impact of the Japanese below-the-knee chronic total occlusion score in patients with chronic limb-threatening ischemia after successful endovascular therapy for below-the-knee chronic total occlusion. Methods: This was a retrospective, single-center observational study. We enrolled 139 consecutive patients with chronic limb-threatening ischemia (149 limbs), who underwent successful endovascular therapy for chronic total occlusion between February 2008 and December 2017. The Japanese below-the-knee chronic total occlusion score was assessed based on the definition of the target arterial path. The evaluation items were the rate of amputation-free survival and wound healing at 1 year, and the association between wound healing at 1 year and the Japanese below-the-knee chronic total occlusion score. Results: The rates of amputation-free survival and wound healing at 1 year were 88.0 and 56.4%, respectively. Multivariate Cox proportional hazard analysis identified direct flow to the wound (hazard ratio: 2.34, 95% confidence interval: 1.28-4.66; p<0.01); Wound, Ischemia, and foot Infection stages 1-3 (hazard ratio: 2.81, 95% confidence interval: 1.63-5.18; p<0.01); and a Japanese below-the-knee chronic total occlusion score ≤1 (hazard ratio: 1.70, 95% confidence interval: 1.02-2.98; p=0.04) to be predictors of wound healing. Conclusions: A Japanese below-the-knee chronic total occlusion score ≤1, direct flow to the wound, and Wound, Ischemia, and foot Infection stages 1-3 were found to be associated with wound healing after successful endovascular therapy for below-the-knee chronic total occlusion in patients with chronic limb-threatening ischemia. Clinical Impact This study was conducted to evaluate the prognostic impact of the Japanese below-the-knee chronic total occlusion (J-BTK CTO) score in patients with chronic limb-threatening ischemia (CLTI) after successful endovascular treatment (EVT). The results showed that the J-BTK CTO score not only evaluates the difficulty of EVT but also can predict limb prognosis. Using the J-BTK CTO score, it seems possible to predict the limb prognosis and make it useful in clinical practice.
Scalable all-textile embedded electrode triboelectric nanogenerator: Hybrid single-electrode and contact-separation working functions for wearable body motion monitoring
Authors: Bakhtiyari Simin , Bagherzadeh Roohollah , Ezazshahabi Nazanin , Jahanshahi Amir , Van Langenhove Lieva , Malengier Benny 
Published: November 2024

Textile-based triboelectric nanogenerators (TENGs) hold considerable promise as sustainable power sources for wearable electronics, yet their seamless integration into everyday clothing remains a challenge. This paper introduces a scalable woven TENG structure that utilizes core−shell yarns composed of commercially available wool and polyester with an inner copper electrode. The device achieves notable performance with an output voltage of 18.5 V, a current of 3.7 µA, and a power density of 51 mW/m2. The novel multilayer design combines hybrid single-electrode and contact-separation approaches, significantly enhancing triboelectric performance and the device’s durability. The multilayer functionality amplifies energy conversion efficiency by increasing the contact area and optimizing charge accumulation through multiple interacting layers. This advanced textile TENG is comfortable, flexible, and aesthetically pleasing while being compatible with large-scale textile manufacturing processes. It demonstrates excellent washability, durability under diverse weather conditions, and resilience to repeated mechanical loading. Highly responsive to a broad range of forces, from gentle taps to strong impacts, this TENG is versatile for body motion monitoring and wearable applications. It represents a significant advancement in creating practical, efficient, and durable energy-harvesting textiles, with promising applications in garment production for precise motion detection, such as for professional athletes and individuals requiring specialized monitoring.
Diurnal response of ecophysiological parameters in kiwifruit under photoselective pearl net
Authors: Riveros-Burgos Camilo , Zúñiga Mauricio , Olguín Jeissy , Pinto Catalina 
Published: November 2024

Background Agricultural adaptation to climate change is crucial, particularly in semi-arid and arid regions. Modern agriculture requires innovative strategies to protect crops from extreme weather events. Photoselective pearl net offers promise in mitigating environmental stresses in kiwifruit production, especially in Chile. Objective This study aims to characterize kiwifruit plants’ diurnal ecophysiological responses under photoselective pearl net. Materials The trial was conducted in a commercial kiwifruit orchard in Chile's Colchagua valley, focusing on ‘Hayward’ vines grown under a photoselective pearl net. A completely randomized design with two treatments (uncovered and covered) was employed. Meteorological parameters, canopy spectral reflectance, vegetative growth, and ecophysiological parameters were evaluated. Results Pearl netting reduced photosynthetically active radiation (PAR), leading to increased shoot length and leaf area. Despite the high variability of the diurnal response of the ecophysiological parameters, there were no significant differences in leaf water potential (ψx) and stomatal conductance (gs) between treatments. Conclusion Photoselective pearl net effectively modifies the light environment, enhancing vegetative growth without compromising key physiological functions. These findings suggest that photoselective netting can improve crop management practices and resilience to climatic variability.
Eco-friendly biodegradable foam composite from natural rubber and cassava starch
Authors: Vudjung Chaiwute , Boonyod Saowaluk , Tongkhamwan Wichan , Khawdas Wichean , Phansroy Nichanan 
Published: November 2024

We thoroughly investigated eco-friendly biodegradable foam from natural rubber (NR) and cassava starch (CS); NR/CS foams. NR, CS, polyethylene glycol (PEG) as a plasticizer, dicumyl peroxide (DCP) as a crosslinker, and azodicarbonamide (ADC) as a blowing agent were compounded in an internal mixer and subsequently cooled down using a two-roll mill. The effect of CS and PEG content on the properties of NR/CS foams was investigated. As evidenced by Mooney viscosity measurement, the viscosity of NR/CS compounds increased with higher CS contents, whereas the viscosity decreased with increasing PEG contents. The rise in viscosity in the NR/CS compounds resulted in increased pore size of NR/CS foams, with pore dimension expanding from 42 to 144 µm as viscosity increased from 17 to 50 ML 1 + 4 at 100°C. The increase in the CS contents in NR/CS foams resulted in an overall decrease in tensile strength, elongation at break, and rebound resilience but provided greater biodegradability. The foam containing 250 phr of CS exhibited a weight retention of only 32% after 1 month of soil burial. On the contrary, with increasing PEG contents, the tensile strength and elongation at break of the NR/CS foams showed an increasing trend. However, rebound resilience and biodegradability decreased. The pore size of the NR/CS foams is a key factor in the water and vegetable oil swelling behavior. The water and vegetable oil swelling increased with an increasing pore size of NR/CS foams. These findings indicated that NR/CS foam has significant potential for various applications, including shockproof and food packaging, while also contributing to the reduction of environmental problems.
Incidence and survival of Interstitial Lung Diseases in the UK in 2010-2019
Authors: Gonnelli Francesca , Eleangovan Neva , Smith Ursie , Heatley Heath , Navarantam Vidya , Corte Tamera J. , Price David B. , Carter Victoria , Bonifazi Martina , Fermoyle Caitlin C. , Hubbard Richard 
Published: November 2024

Backgroundand objective: With the introduction of the antifibrotic drugs targeting progressive pulmonary fibroses, it becomes imperative to provide reliable contemporary estimates of the most common interstitial lung diseases.We then aimed at providing contemporary estimates of the incidence and survival of idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and connective tissue disease associated interstitial lung disease (CTD-ILDs), and to compare their survival to that of the general population. To do this we have used data extracted from the Optimum Patient Care Research Database (OPCRD).MethodsIn this matched cohort study, we extracted incident cases of HP, CTD-ILD and IPF, and age and sex matched controls for each case, for the years 2010–2019. We calculated annual incidence rates, and analysed incidence trends over time using segmented regression modelling. We estimated survival for cases and controls using the Kaplan–Meier model.ResultsWe extracted data for 18 914 incident cases of interstitial lung diseases between 2010 and 2019 from the OPRCD. Incidence rates varied across the different diseases, with rates of 18.12, 7.96, and 2.63 per 100 000 person-years for IPF, CTD-ILD and HP, respectively. 5-year survival for IPF, CTD-ILD and HP was 40%, 54% and 66% respectively, and this was generally approximately 50% lower than that of the general population.ConclusionOur population-based study emphasizes the considerable burden of interstitial lung diseases, with more than 20 000 new cases diagnosed each year in the UK, many of who will be eligible for antifibrotic drugs.
Impact of Seropositivity and DMARDs on Pulmonary Tuberculosis Risk in Rheumatoid Arthritis
Authors: Choi Hayoung , Eun Yeonghee , Han Kyungdo , Jung Jin-Hyung , Jung Wonyoung , Kim Hyungjin , Shin Dong Wook , Lee Hyun 
Published: November 2024

BackgroundIt remains unclear whether active pulmonary tuberculosis (TB) risk is still high in rheumatoid arthritis (RA) patients in settings where TB infection screening is performed before the use of biologics. Moreover, the impacts of seropositivity and disease-modifying antirheumatic drugs (DMARDs) on active pulmonary TB risk should be elucidated.MethodsThe incidence of active pulmonary TB was compared between patients with RA (n=59 577; 41 501 seropositive RA [SPRA] and 18 076 seronegative RA [SNRA]) and 1:5 age- and sex-matched controls without RA (n=297 885) enrolled between 2010–2017. The participants were followed until December 2019.ResultsDuring a median follow-up duration of 4.4 years after 1-year lag period (interquartile range, 2.6–6.4 years; max, 9 years), patients with RA showed a 3.2-fold higher active pulmonary TB risk than matched controls, even after adjusting for potential confounders (95% CI, 2.91–3.55). In an analysis of RA serologic status, patients with SPRA and those with SNRA showed 3.20-fold (95% CI, 2.86–3.58) and 2.54-fold (95% CI, 2.13–3.04) increased risks, respectively, than matched controls. Furthermore, RA patients who were exposed to biologic or targeted synthetic DMARDs and those not exposed to the drugs showed 4.68-fold (95% CI, 3.69–5.93) and 2.88-fold (95% CI, 2.59–3.20) increased risks, respectively, compared to matched controls. In RA patients, active pulmonary TB risk factors included male sex, underweight, and comorbidities such as diabetes mellitus.ConclusionRA patients are prone to active pulmonary TB development, with rates affected by seropositivity and DMARDs. Focused TB screenings may need to be carried out in RA patients based on our results.
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
Authors: Su Zhanhuan , Zhang Yang , Tang Jingqiong , Zhou Yanhong , Long Chen 
Published: November 2024

AbstractHBO1, also known as KAT7 or MYST2, is a crucial histone acetyltransferase with diverse cellular functions. It typically forms complexes with protein subunits or cofactors such as MEAF6, ING4, or ING5, and JADE1/2/3 or BRPF1/2/3, where the BRPF or JADE proteins serve as the scaffold targeting histone H3 or H4, respectively. The histone acetylation mediated by HBO1 plays significant roles in DNA replication and gene expression regulation. Additionally, HBO1 catalyzes the modification of proteins through acylation with propionyl, butyryl, crotonyl, benzoyl, and acetoacetyl groups. HBO1 undergoes ubiquitination and degradation by two types of ubiquitin complexes and can also act as an E3 ubiquitin ligase for the estrogen receptor α (ERα). Moreover, HBO1 participates in the expansion of medullary thymic epithelial cells (mTECs) and regulates the expression of peripheral tissue genes (PTGs) mediated by autoimmune regulator (AIRE), thus inducing immune tolerance. Furthermore, HBO1 influences the renewal of hematopoietic stem cells and the development of neural stem cells significantly. Importantly, the overexpression of HBO1 in various cancers suggests its carcinogenic role and potential as a therapeutic target. This review summarizes recent advancements in understanding HBO1’s involvement in acylation modification, DNA replication, ubiquitination, immunity, and stem cell renewal.
Exploring the attitudes and experiences of Hungarian primary care physicians on the utilisation of digital health solutions
Authors: Girasek Edmond , Döbrössy Bence , Boros Julianna , Győrffy Zsuzsa 
Published: November 2024

Abstract
Background
During the COVID-19 pandemic, digital health solutions ensured the continuity of care especially in primary healthcare practices. COVID-19 accelerated the adoption of digital health solutions. The aim of this study is to describe the digital health-related attitudes and experiences of Hungarian Primary Care Physicians (PCPs) and also analyse the socio-demographic effects on digital health attitudes among PCPs.

Methods
This study used a quantitative and qualitative mixed methodological approach to examine the digital health-related attitudes and experience of Hungarian PCPs. As part of the "E-physicians and E-patients in Hungary" survey, we conducted an online survey among medical doctors working in Hungary between July 2021 to May 2022. A total of 1,774 questionnaires were received, consisting of 1,576 medical doctors and 198 dentists. Among the medical doctors there were 415 primary care physicians (PCPs). In addition to the online questionnaire survey, qualitative research in the form of semi-structured interviews with doctors was also conducted. These interviews took place between October 2021 and June 2022. A total of 62 interviews were conducted,19 with PCPs.

Results
Primary care physicians are more open to technologies that facilitate communication and collaboration with patients, while showing less interest in technologies that support clinical work. Of the demographic variables (age, gender, type of settlement), age was found to have the most significant effect on digital health knowledge, use and intended use. Both the interviews and the multivariate analysis indicate that individuals with greater knowledge, expertise, and experience are more likely to perceive the advantages of digital solutions. This highlights the importance of training, especially given the significant aging population among Hungarian primary care physicians, who may not be accustomed to using these tools naturally. The way PCPs perceive patient expectations regarding the use of digital health tools has a significant impact on the PCPs’ use and intended use of digital tools. When looking at perceived patient needs among PCPs the effect of age and municipality type of PCPs is significant. As age increases, the perception of patient needs decreases (from 5.02 to 4.47), and by municipality type, the average number of perceived needs decreases as one moves from larger cities to smaller municipalities (from 4.85 to 4.14).

Conclusions
Digital health solutions have the potential to enhance the work of PCPs, but successful implementation requires addressing specific needs, demographic differences, and challenges faced by PCPs. Development of infrastructure, education, and institutional support is necessary to ensure more efficient and higher-quality healthcare delivery through the use of digital technologies.
Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma
Authors: Gutzmer Ralf , Leiter Ulrike , Mohr Peter , Kähler Katharina C. , Ascierto Paolo Antonio , Scalvenzi Massimiliano , Peris Ketty , Pérez-Pastor Gemma María , Fernández-de-Misa Ricardo , Botella-Estrada Rafael , Hunger Robert E. , Martelli Serena , Güneli Nur , Arntz Ramon , Hauschild Axel 
Published: November 2024

Abstract
Background
Following the pivotal phase II trial BOLT, the Hedgehog (Hh) inhibitor sonidegib was approved in the EU to treat locally advanced basal cell carcinoma (laBCC) in patients not amenable to surgery or radiotherapy. We report safety data from the interim analysis of the real-world NISSO study.

Methods
NISSO is an ongoing non-interventional, multinational, post-authorization safety study (NCT04066504). Patients with laBCC are treated with sonidegib 200 mg orally once daily and followed for 3 years. Dose modifications were allowed according to the local prescribing information.

Results
Between May 6, 2019, and March 15, 2022, 321 patients with laBCC were enrolled at 46 European sites (data cut-off: June 22, 2023). Treatment was discontinued in 241 (75.1%) patients, with the main reasons being the patient/guardian decision (n = 69, 28.6%), treatment success (n = 40, 16.6%) and the physician decision (n = 35, 14.5%). The median duration of sonidegib exposure was 8.8 months (4.4–13.7 months). Overall, 284 (88.5%) patients had ≥ one treatment-emergent adverse event (TEAE). Most TEAEs were ≤ grade 2 and the most common were muscle spasms (n = 141; 43.9%), dysgeusia (n = 119; 37.1%), and alopecia (n = 97; 30.2%). After 3 months of treatment, the cumulative rates of muscle spasms, dysgeusia, and alopecia were 21.8%, 16.2%, and 3.7%, respectively. TEAEs led to treatment discontinuation in 59 (18.4%) patients, while 149 (46.4%) patients had at least one TEAE leading to dose reduction or interruption. Serious drug-related TEAEs were reported in 13 (4.1%) patients.

Conclusions
These results confirm the safety profile previously observed. Most patients experienced the onset of common TEAEs after 3 months of treatment, and the cumulative incidence of most common TEAEs was 10–20% lower compared to the BOLT study, except for dysgeusia and fatigue that had a similar incidence. The percentage of patients experiencing TEAEs requiring interruption or dose reduction was similar to the BOLT study, while the proportion of patients with TEAE leading to discontinuation of sonidegib was lower. This study demonstrates that the tolerability of sonidegib is manageable in routine clinical practice.
Trial registration.
NCT04066504.
Impact of New York City’s 4-year multi-component natural experiment to improve elementary school physical education on student cardiorespiratory fitness
Authors: Thompson Hannah R. , Madsen Kristine A. , Nguyen Caroline , McKenzie Thomas L. , Picciotto Sally 
Published: November 2024

Abstract
Background
School physical education is an important population-level health intervention for improving youth fitness. This study estimated the impact of New York City’s PE Works program - which included providing PE teachers, training for classroom teachers, and administrative/ teacher support for PE - on student cardiorespiratory fitness as measured by the FitnessGram’s 15-meter PACER test for aerobic capacity.

Methods
This longitudinal study (2014/15-2018/19) includes 581 elementary schools (n = 315,999 4th /5th -grade students; 84% non-white; 74% who qualify for free or reduced-price meals, a proxy for socioeconomic status). We apply the parametric g-formula to address schools’ time-varying exposure to intervention components and time-varying confounding.

Results
After four years of staggered PE Works implementation, 49.7% of students/school (95% CI: 42.6%, 54.2%) met age/sex-specific Healthy Fitness Zone (HFZ) aerobic capacity standards set by the FitnessGram. Had PE Works not been implemented, we estimate 45.7% (95% CI: 36.9%, 52.1%) would have met aerobic capacity HFZ standards. Had PE Works been fully implemented in all schools from the program’s inception, we estimate 57.4% (95% CI: 49.1%, 63.3%) would have met aerobic capacity HFZ standards. Adding a PE teacher, alone, had the largest impact (6.4% (95% CI: 1.0, 12.0) increase).

Conclusion
PE Works positively impacted student cardiorespiratory fitness. Mandating and funding multicomponent PE programs is an important public health intervention to increase children’s cardiorespiratory fitness.