bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound-guided tendon fenestration versus open-release surgery for the treatment of chronic lateral epicondylosis of the elbow: protocol for a prospective, randomised, single blinded study
Authors: Lungu Eugen , Grondin Philippe , Tétreault Patrice , Desmeules François , Cloutier Guy , Choinière Manon , Bureau Nathalie J 
Published: June 2018

IntroductionChronic lateral epicondylosis (CLE) of the elbow is a prevalent condition among middle-aged people with no consensus on optimal care management but for which surgery is generally accepted as a second intention treatment. Among conservative treatment options, ultrasound (US)-guided fenestration has shown encouraging results that should be explored before surgery is considered. The primary objective of this study is to compare the efficacy of US-guided fenestration with open-release surgery in patients with failure to improve following a minimum 6 months of conservative treatment.Methods and analysisThis study protocol entails a two-arm, single-blinded, randomised, controlled design. Sixty-four eligible patients with clinically confirmed CLE will be assigned to either US-guided fenestration or open-release surgery. Fisher’s exact test will be used to compare the proportion of patients reporting a change of 11/100 points or more in thePatient Rated Tennis Elbow Evaluationscore at 6 months, according to an intention-to-treat analysis. Secondary analyses will compare the two treatment groups in terms of pain and disability, functional limitations at work, pain-free grip strength, medication burden, patients’ global impression of change and level of satisfaction at 6 weeks, 3, 6 and 12 months, using mixed linear models for repeated measures or Fisher’s exact test, as appropriate. Finally, recursive partitioning analyses will investigate US and elastography parameters as predictors of treatment success at 6 and 12 months. This data will contribute to evidence-based treatment guidelines for CLE and explore the value of imaging biomarkers to improve risk stratification plans and assist clinicians.Ethics and disseminationThe study has been approved by the Research Ethics Board of our institution on 23 March 2016 (REB 15.327). In case of important protocol modifications, a new version of the protocol with appropriate amendments will be submitted to the REB for approval. Study results will be published in peer-reviewed journals and presented at local, national and international conferences.Trial registration numberNCT02710682.
Beyond the limbic system: disruption and functional compensation of large-scale brain networks in patients with anti-LGI1 encephalitis
Authors: Heine Josephine , Prüss Harald , Kopp Ute A , Wegner Florian , Then Bergh Florian , Münte Thomas , Wandinger Klaus-Peter , Paul Friedemann , Bartsch Thorsten , Finke Carsten 
Published: June 2018

ObjectiveHippocampal inflammation in anti-LGI1 encephalitis causes memory deficits, seizures and behavioural abnormalities. Recent findings suggest that extralimbic brain areas are additionally affected and that patients also suffer from non-limbic cognitive symptoms. Moreover, up to 60% of patients show no structural MRI abnormalities in the acute disease stage. We therefore investigated whether functional connectivity analyses can identify brain network changes underlying disease-related symptoms.MethodsWe studied 27 patients and a matched healthy control group using structural and functional MRI. Intrinsic functional networks were analysed using Independent Component Analysis and Dual Regression. Cognitive testing covered working memory, episodic memory, attention and executive function.ResultsOur analysis revealed functional connectivity alterations in several large-scale networks, including the default mode network (DMN) which showed an aberrant structure-function relationship with the damaged hippocampus. In addition, connectivity in the sensorimotor, salience and higher visual networks was impaired independent of hippocampal damage. Increased connectivity in ventral and dorsal DMN regions significantly correlated with better memory performance. In contrast, stronger connectivity of the insula with the salience network and DMN was linked to impaired memory function.ConclusionsAnti-LGI1 encephalitis is associated with a characteristic pattern of widespread functional network alterations. Increased DMN connectivity seems to represent a compensatory mechanism for memory impairment induced by hippocampal damage. Network analyses may provide a key to the understanding of clinical symptoms in autoimmune encephalitis and reveal changes of brain function beyond apparent structural damage.
The 7th French Airborne Forward Surgical Team experience of surgical support to the population of a low-income country: a prospective study on 341 patients with short-term follow-up
Authors: Goudard Yvain , Butin C , Carfantan C , Pauleau G , Soucanye de Landevoisin E , Goin G , Clement D , Bordes J , Balandraud P 
Published: June 2018

BackgroundThe 7th Airborne Forward Surgical Team (FST) has deployed to Chad in 2015 and 2016, in support of French military forces. Humanitarian surgical care is known to represent a significant part of the surgical activity in such missions, but to date limited data have been published on the subject.MethodsAll surgical patients from a civilian host population treated by the FST during these missions have been prospectively included. Indications, operative outcomes and postoperative outcomes were evaluated.ResultsDuring this period, the FST operated on 358 patients. Humanitarian surgical care represented 95% of the activity. Most patients (92.7%) were operated for elective surgery. Emergencies and infectious diseases represented, respectively, 7.3% and 9.1% of cases. The mean length of stay (LOS) was three days (2–4), and the median follow-up was 30 days (22–34). Mortality rate was 0.6% and morbidity was 5.6%. Parietal surgery had no significant complication and had shorter LOS (p<0.001). Emergent surgeries were more complicated (p<0.01) and required more reoperations (p<0.05). Surgical infectious cases had longer LOS (p<0.01).ConclusionsHumanitarian surgical care can be provided without compromising the primary mission of the medical forces. Close surveillance and follow-up allowed favourable outcomes with low morbidity and mortality rates. Humanitarian care is responsible for a considerable portion of the workload in such deployed surgical teams. Accounting for humanitarian care is essential in the planning and training for such future medical operations.
Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France
Authors: Boucher Anne , Meybeck Agnes , Alidjinou Kazali , Huleux Thomas , Viget Nathalie , Baclet Veronique , Valette Michel , Alcaraz Isabelle , Sauser Eveline , Bocket Laurence , Faiza Ajana 
Published: June 2018

Objectives
Since February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North of France. We aimed to report clinical and virological features of 49 cases treated in three hospitals in Lille European Metropolis (LEM).

Methods
All adult patients treated for AHA in 3 LEM hospitals between 20 February and 5 July 2017 were included. Demographic characteristics, exposure risk factors to hepatitis A virus (HAV), AHA manifestations and concomitant sexually transmitted infections (STI) were retrospectively recorded.

Results
Forty-nine cases of AHA were diagnosed among which 34 (69%) were hospitalised. Severe AHA occurred in 7 (14%) patients. The median age of cases was 36 years. All cases except 1 were men and 32 (65%) were identified as men having sex with men (MSM). Eleven (23%) patients were HIV-infected, 5 were under HIV pre-exposure prophylaxis (PrEP), 6 had a history of HIV postexposure prophylaxis and 19 had a history of at least one STI. Only three patients had received HAV vaccine. Proportion of patients tested for syphilis, chlamydial and gonococcal infections was 75% (18/24) in those seen by sexual health specialists and 21% (6/29) in those seen by other specialists. At least one concomitant STI was diagnosed in 13 out of 24 tested patients (54%). RT-PCR sequencing was available for 38 cases and confirmed co-circulation of 3 different strains of subgenotype IA (VRD 521 2016: n=24, RIVM-HAV16-090: n=13, V16-25801: n=1), already identified in several European countries.

Conclusions
We are facing an outbreak of AHA among MSM in the North of France with a high rate of hospitalisation. Analysis of cases highlighted missed opportunities of vaccination and lack of concomitant STI screening. Awareness among healthcare providers and MSM should be increased and HAV vaccination promoted.
Role of habit in treatment adherence among adults with cystic fibrosis
Authors: Hoo Zhe Hui , Gardner Benjamin , Arden Madelynne A , Waterhouse Simon , Walters Stephen J , Campbell Michael J , Hind Daniel , Maguire Chin , Dewar Jane , Wildman Martin J 
Published: June 2018

Among adults with cystic fibrosis (CF), medication adherence is low and reasons for low adherence are poorly understood. Our previous exploratory study showed that stronger ‘habit’ (ie, automatically experiencing an urge to use a nebuliser) was associated with higher nebuliser adherence. We performed a secondary analysis of pilot trial data (n=61) to replicate the earlier study and determine whether habit–adherence association exists in other cohorts of adults with CF. In this study, high adherers also reported stronger habit compared with low adherers. Habit may be a promising target for self-management interventions.Trial registration numberACtiF pilot, ISRCTN13076797.
Immunity War: A Novel Therapy for Lymphoma Using T-cell Bispecific Antibodies
Authors: Prakash Ajay , Diefenbach Catherine S. 
Published: June 2018

Abstract
The activity of T-cell–mediated immunotherapies in B-cell lymphoma has been limited to date. The novel bispecific antibody CD20-TCB has a 2:1 antibody design to maximize T-cell engagement and demonstrates activity in preclinical models. This may represent a novel therapeutic approach for patients with relapsed/refractory non-Hodgkin lymphoma (NHL). Clin Cancer Res; 24(19); 4631–2. ©2018 AACR.
See related article by Bacac et al., p. 4785
Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT‐AF
Authors: O'Brien Emily C. , Holmes DaJuanicia N. , Thomas Laine , Fonarow Gregg C. , Kowey Peter R. , Ansell Jack E. , Mahaffey Kenneth W. , Gersh Bernard J. , Peterson Eric D. , Piccini Jonathan P. , Hylek Elaine M. 
Published: June 2018

Background

Oral anticoagulation (
OAC
) reduces stroke risk in atrial fibrillation, but bleeding is a frequent side effect. The decision to discontinue or modify medication regimens in response to a bleeding event may differ according to bleeding site and severity.

Methods and Results

We used data from a large, national outpatient registry,
ORBIT
‐
AF
(Outcomes Registry for Better Informed Treatment of Atrial Fibrillation; 2010–2011), to evaluate event characteristics and OAC management following the first bleeding event occurring during follow‐up. Bleeding events were classified into 3 categories: (1) International Society of Thrombosis and Hemostasis major bleeding, (2) clinically relevant nonmajor bleeding requiring medical attention, and (3) nuisance bleeding not requiring medical attention (eg, bruising, hemorrhoidal bleeding). Of 9743 patients enrolled in
ORBIT
‐
AF
with follow‐up data, 510 (3.23/100 subject‐years) experienced a major bleed, 615 (3.90/100 subject‐years), experienced a clinically relevant nonmajor bleed, and 1558 (9.87/100 subject‐years) experienced a nuisance bleed, among first bleeds over 2 years. Nearly one third of patients (31.6%) discontinued
OAC
therapy following a major bleeding event, 12.7% following a clinically relevant nonmajor bleed, and 4.5% following a nuisance bleed. Compared with those who experienced a clinically relevant nonmajor or nuisance bleed, patients who experienced a major bleed were more likely to be black and female and to have a history of heart failure and stroke. Those who discontinued were more likely to have central nervous system or gastrointestinal bleeding than those who persisted on
OAC
therapy.

Conclusions

Overall, 1 in 3 patients who experienced a major bleed was no longer anticoagulated after the event. Those who discontinued
OAC
were more likely to have central nervous system or gastrointestinal bleeding than those who persisted on
OAC
.
Methodologic Differences Across Studies of Patients With Atrial Fibrillation Lead to Varying Estimates of Stroke Risk
Authors: Quinn Gene R. , Severdija Olivia N. , Chang Yuchiao , Dallalzadeh Liane O. , Singer Daniel E. 
Published: June 2018

Background

Guidelines for anticoagulation in atrial fibrillation (
AF
) assume that stroke risk scheme point scores correspond to fixed stroke rates. However, reported stroke rates vary widely across
AF
cohort studies, including studies from the same country. Reasons for this variation are unclear. This study compares methodologies used to assemble and analyze large
AF
cohorts worldwide and assesses potential bias in estimating stroke rates.

Methods and Results

From a previous systematic review of
AF
cohorts, we analyzed studies including at least 5000 patients. We assessed methods used to generate rates of ischemic stroke off anticoagulants, according to a structured inventory of database interrogation methods. Nine studies (497 578 total patients) met our criteria. Overall cohort stroke rates ranged from 0.45% to 7.03% per year. In bivariate study‐level analysis, multiple features were associated with higher stroke rates, including
AF
identified as inpatients versus outpatients (rate ratio 2.60, 95% confidence interval, 1.19, 5.68), and lack of clinical validation of outcome events (rate ratio 4.09, 95% confidence interval, 1.06, 15.70). European studies reported rates more than 4‐fold higher than North American studies.
International Classification of Diseases (ICD)
coding schemes for outcomes varied widely. Multiple high rate features coexisted in the same studies.

Conclusions

Among
AF
cohort studies, differences in the composition, method of assembly, determination of clinical features and outcomes, and analytic approach were strongly associated with reported stroke rates. Our study highlights the need for standardized and validated methodologies for
AF
cohort assembly and analysis to generate accurate stroke rates to better support anticoagulation guidelines for patients with
AF
.
Emotional Rescue
Authors: Moralee Jason 
Published: June 2018

AbstractIndividuals, city-states, and small-scale communities of worshippers memorialized instances when they were rescued from danger. They did so in a variety of ways, from staging fictional accounts of danger and deliverance to the public praise of local patriots and annual festivals in honor of gods and goddesses for their roles in saving the community. This article examines the significance of epigraphic narratives of endangerment and rescue from the third centuryBCto the third centuryAD. It argues that these inscriptions joined individuals into an emotional community of those whose lives had been touched by the gods. These epigraphic narratives point to the social significance of having a status as one rescued by the gods. Talking about one’s own weakness, vulnerability, and misfortune was a key way for individuals andpoleisto claim rights and privileges within communities, between them, and across time.
An open label, prospective, multicenter, non-interventional study of iodixanol 270 mg I/mL for use in individuals undergoing computed tomography angiography in real-world clinical practice
Authors: Du Xiangying , Lu Bin , Hu Daoyu , Song Bin , Li Kuncheng 
Published: June 2018

Background Concern about radiation exposure is leading to an increasing interest in low-concentration contrast medium administration. Purpose To evaluate the image quality and safety profile after administration of iodixanol 270 mg I/mL at 100-kVp tube voltage with iterative reconstruction in subjects undergoing computed tomography angiography (CTA). Material and Methods Patients who completed CTA examination using iodixanol 270 mg I/mL and 100-kVp tube voltage along with iterative reconstruction for coronary, aortic, head and neck, renal, or pulmonary arteries were included. Image quality was qualitatively and quantitatively evaluated. Incidence of adverse events (AEs) and adverse drug reactions (ADRs) within seven days and radiation dose were also analyzed. Results A total of 4513 individuals in 42 centers in China were enrolled, among which 4367 were included in efficacy analysis. The mean image quality score was 4.8 ± 0.45 across all arteries (all above 4.6) and 99.7% of the individuals’ images were classified as evaluable. The CT attenuation, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) in the regions of interest (ROIs) were 431.79 ± 99.018, 18.29 ± 11.947, and 28.21 ± 19.535 HU, respectively. Of all the participants, 68 (1.5%) and 65 (1.4%) experienced AEs and ADRs, respectively. No serious AEs or AEs leading to discontinuation occurred. The average effective radiation dose was 3.13 ± 2.550 mSv. Conclusion Iodixanol 270 mg I/mL in combination with 100-kVp tube voltage and iterative reconstruction could be safely applied in CTA and yield high-quality and evaluable images with reduced radiation dose.
The Effect of Activity Restriction on Infant’s Birth Weight and Gestational Age at Birth: PRAMS Data Analysis
Authors: Omar Abeer 
Published: June 2018

Background: Activity restriction is extensively prescribed for pregnant women with major comorbidities despite the lack of evidence to support its effectiveness in preventing preterm birth or low birth weight. Purpose: To determine the moderation effect of home activity restriction for more than a week on infant’s birth weight and gestational age at birth for high-risk women with obstetrical and medical comorbidities. Methods: A secondary analysis of 2004–2008 New York Pregnancy Risk Assessment Monitoring System was conducted with 1426 high-risk women. Results: High-risk group included 41% of women treated with activity restriction and 59% of those not treated with activity restriction. Women with preterm premature rupture of membrane (PPROM) who were treated with activity restriction had a lower infant birth weight ( b = −202.85, p = ≤.001) and gestational age at birth ( b = −.91, p = ≤.001) than those without activity restriction. However, women with preterm labor and hypertensive disorders of pregnancy who were not treated with activity restriction had lower infant gestational age at birth ( b = −96, p = ≤.01) and ( b = −92, p = ≤.001), respectively, compared to those who were treated with activity restriction. Conclusion: Findings suggest a contrary effect of activity restriction on infants born to women with PPROM, which is a major reason for prescribing activity restriction. The current study results may trigger the need to conduct randomized control trials to determine the effect of severity of activity restriction on maternal and infant outcomes.
“I’ve learned to just go with the flow”: Family caregivers’ strategies for managing behavioral and psychological symptoms of dementia
Authors: Polenick Courtney A , Struble Laura M , Stanislawski Barbara , Turnwald Molly , Broderick Brianna , Gitlin Laura N , Kales Helen C 
Published: June 2018

Background and objectives Behavioral and psychological symptoms of dementia are highly prevalent, stressful, and challenging to manage. Caregivers’ approaches for handling these behaviors have implications for both care partners’ well-being. Yet the specific strategies that caregivers use in their daily management of behavioral and psychological symptoms of dementia are relatively unknown. This study used in-depth focus group data to examine family caregivers’ strategies for managing behavioral and psychological symptoms of dementia. Design As part of a larger study (NINR R01NR014200), four focus groups were conducted with a total of 26 family caregivers of older adults with dementia. Caregivers were asked to describe the strategies they use to manage behavioral and psychological symptoms of dementia. Data from audio-recorded sessions were transcribed, coded to identify relevant concepts, and reduced to determine major categories. Results Caregivers managed behavioral and psychological symptoms of dementia through (1) modifying interactions within the care dyad (e.g., simplifying communication); (2) modifying the care environment (e.g., using written prompts); (3) activity engagement; (4) humor; (5) self-care; and (6) social support. Conclusion Family caregivers manage behavioral and psychological symptoms of dementia using strategies to minimize stress and address the needs of both care partners. Caregivers’ own accounts of these approaches reveal a window into their everyday management of difficult behaviors. The present findings generate key information for routine clinical care and targeted interventions to promote caregiver well-being.
Exploring Leaders’ Discriminatory, Passive-Aggressive Behavior Toward Protected Class Employees using Diversity Intelligence
Authors: Hughes Claretha , Brown Lucy M. 
Published: June 2018

The Problem As there is diversity in many workplaces, diversity intelligence (DQ) needs to be integrated alongside intellectual, emotional, and cultural intelligences to be effective. DQ requires leaders to have knowledge to understand protected class employees and the legal mandates and executive orders established to protect those employees from discriminatory practices at work. Irrespective of the billions of dollars invested in diversity or antidiscriminatory practices training, many protected class workers remain underutilized or marginalized due to leaders’ unfamiliarity with these groups of workers and/or incompetence to harness their talents to achieve organizational goals. DQ deficiencies trigger some leaders to apply passive-aggressive behaviors as a coping mechanism. These passive-aggressive behaviors can lead to a toxic and hostile work environment as evidenced through high attrition, unrealized productivity, feelings of frustration, fear, disappointment, resentment, among other adverse responses from both leaders and employees. The Solution To efficiently and effectively integrate protected class employees to contribute at their optimum levels, leaders need to possess DQ. Leaders in this study need to be educated or reeducated so that they understand who protected class employees are in the workplace. The Stakeholders Implications for human resource development professionals and researchers are offered. Opportunities for workplace leaders and protected class employees are presented.
The Diversity Intelligent Servant Leader: Developing Leaders to Meet the Needs of a Diverse Workforce
Authors: Sims Cynthia M. 
Published: June 2018

The Problem The ability of organizations to realize diversity remains problematic. To meet the needs of the modern workforce, new diversity and leadership approaches are required. The Solution Diversity intelligence, a promising new human resource development (HRD) tool, leads to enhanced inclusion and equitable treatment in the workplace. Several propositions herein advance that diversity intelligence is an antecedent to the compassionate love servant leadership model. The author describes the potential value diversity intelligent servant leaders provide to society, organizations, leaders, and especially employees with protected class status. This article addresses the implications of the propositions to theory and explores the intersection of servant leadership and diversity and inclusion research streams, practice describes how organizations and HRD professionals can benefit from and implement these arguments, and social impact discusses the benefits society can accrue when all organizational members are engaged, productive and valued. The Stakeholders This article benefits organizations, leaders, employees, and HRD professionals as well as leadership and diversity and inclusion scholars and practitioners.