bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermanual transfer of visuomotor adaptation is related to awareness
Authors: Werner Susen , Strüder Heiko K. , Donchin Opher 
Published: April 2019

AbstractPrevious studies compared the effects of gradual and sudden adaptation on intermanual transfer to find out whether transfer depends on awareness of the perturbation. Results from different groups were contradictory. Since results of our own study suggest that awareness depends on perturbation size, we hypothesize that awareness-related intermanual transfer will only appear after adaptation to a large, sudden perturbation but not after adaptation to a small sudden perturbation or a gradual perturbation, large or small. To confirm this, four groups (S30, G30, S75, G75) of subjects performed out-and-back reaching movements with their right arm. In a baseline block, they received veridical visual feedback of hand position. In the subsequent adaptation block, feedback was rotated by 30 deg (S30, G30) or 75 deg (S75, G75). This rotation was either introduced suddenly (S30, S75) or gradually in steps of 3 deg (G30, G75). After the adaptation block, subjects did an awareness test comprising exclusion and inclusion conditions. The experiment concluded with an intermanual transfer block, in which movements were performed with the left arm under rotated feedback, and a washout block again under veridical feedback. We used a hierarchical Bayesian model to estimate individual movement directions and group averages. The movement directions in different conditions were then used to calculate group and individual indexes of adaptation, awareness, unawareness, transfer and washout. Both awareness and transfer were larger in S75 than in other groups, while unawareness and washout were smaller in S75 than in other groups. Furthermore, the size of awareness indices correlated to intermanual transfer across subjects, even when transfer was normalized to final adaptation level. Thus, we show for the first time that the amount of intermanual transfer directly relates to the extent of awareness of the learned perturbation.
G-protein coupled receptor 88knock-down in the associative striatum reduces the psychiatric symptoms in a translational model of Parkinson’s disease
Authors: Galet Benjamin , Ingallinesi Manuela , Pegon Jonathan , Thi Anh Do , Ravassard Philippe , Biguet Nicole Faucon , Meloni Rolando 
Published: April 2019

ABSTRACTBeyond the motor disability, Parkinson’s disease (PD) is also characterized by an early appearance of psychiatric symptoms such as apathy, depression, anxiety and cognitive deficits, which can entail dementia and psychosis in later stages. While current treatments may provide some level of symptomatic relief, their use is limited by the development of adverse effects such as impulse-control disorders. There is thus a medical need for targets with novel modes of action to treat these aspects of PD. In this context, we investigated GPR88, an orphan G-protein coupled receptor that is associated with psychiatric disorders and highly enriched in the striatum, where it exerts an inhibitory control over neurotransmitter systems that are compromised in PD. To evaluate the potential of GPR88 as a target for the treatment of the psychiatric symptoms of PD, we knocked-down (KD) its expression in sensorimotor (dorsolateral, DLS) or associative (dorsomedial, DMS) striatal areas in a translational rat model of early PD. Our findings indicate thatGpr88-KD in the DMS, but not DLS, reduced the alterations in mood, motivation and cognition that characterized the model, through modulation of the expression ofregulator of G-protein signaling 4(Rgs4) and of transcription factor ΔFosB. Furthermore, the rat model of PD exhibited allostatic changes in striatal activity markers that may be related to patterns observed in patients, and which were reduced byGpr88-KD. Taken together, these results thus highlight the relevance of GPR88 as a therapeutic target for the psychiatric symptoms of PD.
An enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)
Authors: Aird Eric J. , Tompkins Kassidy J. , Gordon Wendy R. 
Published: April 2019

ABSTRACTMolecular tension sensors measure piconewton forces experienced by individual proteins in the context of the cellular microenvironment. Current genetically-encoded tension sensors use FRET to report on extension of an elastic peptide encoded in a cellular protein of interest. Here we present the development and characterization of a new type of molecular tension sensor based on bioluminescence resonance energy transfer (BRET) which exhibits more desirable spectral properties and an enhanced dynamic range compared to other molecular tension sensors. Moreover, it avoids many disadvantages of FRET measurements in cells, including heating of the sample, autofluorescence, photobleaching, and corrections of direct acceptor excitation. We benchmark the sensor by inserting it into the canonical mechanosensing focal adhesion protein vinculin, observing highly resolved gradients of tensional changes across focal adhesions. We anticipate that the BRET-TS will expand the toolkit available to study mechanotransduction at a molecular level and allow potential extension to an in vivo context.
Infant Sleep Quality and its’ Several Related Factors: An Indonesian Samples
Authors: Muskananfola Fiona , Wiguna Tjhin , Ismail Raden Irawati , Nugraheni Teresia Putri Widia , Chairunnisa Shafira 
Published: April 2019

AbstractObjectiveThis research aimed to identify factors influencing infant sleep quality including mother-infant bonding, infant stress, parity, and maternal depression and anxiety, and to analyze possible associations between these variables.MethodA cross-sectional design was adopted to analyze data from mothers and their infants (0–36 months of age) using consecutive sampling. Mothers completed two of several questionnaires in the Indonesian language, including the Mother-Infant Bonding Scale, the Brief Infant Sleep Questionnaire, the Symptoms Checklist-90, and an infant stress questionnaire that was specifically designed for this study. The chi-squared test for bivariate analysis and logistic regression were applied to obtain odds ratios for the predictor variables using SPSS version 21 (IBM Corporation, Armonk, NY, USA) for Mac (Apple Inc, Cupertino, CA, USA).ResultsFindings indicated that the proportion of infants with problematic sleep quality was 33.30%. Three predictors were significantly associated with problematic infant sleep quality: mother-infant bonding; infant stress; and parity. However, logistic regression analysis demonstrated that only mother-infant bonding (odds ratio [OR] 1.66 [95% confidence interval (CI) 1.15–6.12]) and infant stress (OR 1.29 [95% CI 1.07–2.68]) predicted a 38.7% risk for problematic infant sleep quality.ConclusionResults of the present study indicated that early detection of mother-infant bonding levels and infant stress is very important. It may be valuable to screen sleep habits for better prognosis among infants because good sleep quality is crucial for optimal growth and development. Results of this study will raise awareness of the importance of mother-infant bonding, infant stress, and problematic infant sleep quality.
Selection shapes synonymous stop codon use in mammals
Authors: Seoighe Cathal , Kiniry Stephen J. , Peters Andrew , Baranov Pavel V. , Yang Haixuan 
Published: April 2019

AbstractPhylogenetic models of the evolution of protein-coding sequences can provide insights into the selection pressures that have shaped them. In the application of these models synonymous nucleotide substitutions, which do not alter the encoded amino acid, are often assumed to have limited functional consequences and used as a proxy for the neutral rate of evolution. The ratio of nonsynonymous to synonymous substitution rates is then used to categorize the selective regime that applies to the protein (e.g. purifying selection, neutral evolution, diversifying selection). Here, we extend these models to explore the extent of purifying selection acting on substitutions between synonymous stop codons. Using a large collection of coding sequence alignments we estimate that a high proportion (approximately 57%) of mammalian genes are affected by selection acting on stop codon preference. This proportion varies substantially by codon, with UGA stop codons far more likely to be conserved. Genes with evidence of selection acting on synonymous stop codons have distinctive characteristics, compared to unconserved genes with the same stop codon, including enrichment for specific functional properties. Notably, genes with conserved stop codons have longer 3’ UTRs and are associated with shorter mRNA half-life than other genes. The coding regions of these genes are also much more likely to be under strong purifying selection pressure. Our results suggest that the preference for UGA stop codons found in many multicellular eukaryotes is selective rather than mutational in origin.
Taking Britain from darkness into light
Authors: Van Der Laan Sandra , Moerman Lee , Campbell David 
Published: April 2019

PurposeThis paper aims to contribute to an understanding of the process of the construction of the professional businessman in Britain in the early twentieth century.Design/methodology/approachTwo books authored by the prominent British industrialist Sir Samuel Turner III are analysed as a form of contemporaneous discourse. This allows for examination of the texts as a particular genre of social media within their social, economic and political contexts.FindingsSir Samuel Turner III derived the elite status from his family’s standing as a prominent Lancashire, church-going, industrial dynasty. The role of business and the businessman as a professional are recast as the means to restore Britain to its former pre-World War I glory – a position that continues to resonate in a variety of contexts today.Originality/valueThe paper contributes to our understanding of the construction of the social world through discourse. While Turner’s ideology of the relationship between labour, capital, business and society may appear quaint to our twenty-first-century experiences, it is nevertheless an important reminder that the elite voice influences political and social action.
Viewpoint: conveying managerial relevance into service research
Authors: Klaus Philipp Phil 
Published: April 2019

PurposeThis paper aims to propose opportunities on how service research scholars can overcome the challenge of designing, delivering and disseminating managerial relevant studies. The proposed tactics will assist researchers and the community in general to resolve the pressing issues of both, the disconnection between theory formulation and verification and the divide between pursuing theoretical advances versus managerial usefulness.Design/methodology/approachBuilding on insights deriving from academic research, managerial publications and managerial feedback, the paper explores how to turn the challenges of developing managerial relevant research into opportunities.FindingsUsing communication research insights, the paper submits that, contrary to common belief, conducting managerial relevant research is not necessarily the main challenge for service researchers. The author identifies the main communications challenges according to three stages, designing, delivering and disseminating research with managerial relevance to the business community, leading to the phenomenon labeled as “lost before, and in translation.”Research limitations/implicationsThis paper highlights the developments leading to service research’s lack of managerial relevance perception. Using these insights, the author develops detailed chronological strategies and tactics how to change these perceptions into more favorable ones by designing, delivering and communicating research’s benefits of the research in a better, more efficient and impactful fashion, catered to the managerial audience.Practical implicationsThe strategies and tactics outline build a practical “how-to” foundation for researcher to develop managerial relevant research, increase their publication chances and tap into new networks, data collection and funding opportunities.Originality/valueThis is the, to the author’s knowledge, first study to shed new light on the challenge of conducting managerial relevant research by not challenging the notion of relevance, but the way relevance is communicated, disseminated and originated.
The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation
Authors: Tingstedt Jeanette Linnea , Hove‐Skovsgaard Malene , Gaardbo Julie , Ullum Henrik , Nielsen Susanne Dam , Gelpi Marco 
Published: April 2019

Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non‐AIDS‐related morbidities, including cardiovascular diseases (CVD). Type 2 diabetes (T2D) is also characterized by immune activation and inflammation. We aimed to investigate the impact of concurrent HIV infection and T2D on T‐cell subsets. The study included PLWH with T2D (HIV+T2D+, N = 25) and without T2D (HIV+T2D−, N = 25) and HIV‐negative controls with T2D (HIV−T2D+, N = 22) and without T2D (HIV−T2D−, N = 28). All PLWH in the study were receiving combination antiretroviral therapy. We examined T‐cell homeostasis by determining T‐cell subsets (immune maturation, immune regulation and immune activation) using flow cytometry. HIV+T2D− had lower proportion of Tc17 cells and higher proportion of apoptotic cells than HIV−T2D−. When comparing HIV+T2D+ and HIV+T2D− a lower proportion of CD4+ recent thymic emigrants (RTE) was found (p = 0.028). Furthermore, HIV+T2D+ had a higher proportion of non‐suppressive CD4+ Tregs compared to HIV+T2D− (p = 0.010). In conclusion, even in the setting of treated HIV infection, distinct immunological alterations are found. In PLWH with concomitant T2D, most alterations in T‐cell subsets were related to HIV and only few differences were found between PLWH with and without diabetes.
Editorial: effects of vildagliptin on GLP‐1 levels, gastric motor functions and food intake. A authors' reply
Authors: Masuy Imke , Rotondo Alessandra , Verbeure Wout , Biesiekierski Jessica R. , Deloose Eveline , Tack Jan 
Published: April 2019

Linked ContentThis article is linked to Rotondo et al and Camelleri papers. To view these articles, visit https://doi.org/10.1111/apt.15195 and https://doi.org/10.1111/apt.15206.
A five‐CpG signature of microRNA methylation in non‐G‐CIMP glioblastoma
Authors: Kang En‐Ming , Yin An‐An , He Ya‐Long , Chen Wei‐Jun , Etcheverry Amandine , Aubry Marc , Barnholtz‐Sloan Jill , Mosser Jean , Zhang Wei , Zhang Xiang 
Published: April 2019

SummaryAimsDNA methylation has been found to regulate microRNAs (miRNAs) expression, but the prognostic value of miRNA‐related DNA methylation aberration remained largely elusive in cancers including glioblastomas (GBMs). This study aimed to investigate the clinical and biological feature of miRNA methylation in GBMs of non‐glioma‐CpG island methylator phenotype (non‐G‐CIMP).MethodsPrognostic miRNA methylation loci were analyzed, with TCGA and Rennes cohort as training sets, and independent datasets of GBMs and low‐grade gliomas (LGGs) were obtained as validation sets. Different statistical and bioinformatic analysis and experimental validations were performed to clinically and biologically characterize the signature.ResultsWe identified and validated a risk score based on methylation status of five miRNA‐associated CpGs which could predict survival of GBM patients in a series of training and validation sets. This signature was independent of age and O‐6‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation status. The risk subgroup was associated with angiogenesis and accordingly differential responses to bevacizumab‐contained therapy. MiRNA target analysis and in vitro experiments further confirmed the accuracy of this signature.ConclusionThe five‐CpG signature of miRNA methylation was biologically relevant and was of potential prognostic and predictive value for GBMs. It might be of help for improving individualized treatment.
Drivers of plant functional group richness and beta diversity in fire‐dependent pine savannas
Authors: Freeman Johanna E. , Kobziar Leda N. , Leone Erin H. , Williges Kent 
Published: April 2019

AbstractAimTo assess the drivers of plant functional group richness and beta diversity in fire‐maintained North American Coastal Plain (NACP) savannas.LocationThe southern portion of the NACP, a global biodiversity hotspot. This region is characterized by fire‐dependent pine savanna fragments that are isolated within a matrix of agriculture, urban development, non‐pyrogenic plant communities and plantation forestry.MethodsWe used nested quadrats to sample plant species on 30 fire‐maintained savanna preserves in Florida and Georgia, USA. We analysed between‐site Sørenson dissimilarity, a measure of beta diversity, using NMDS and PerMANOVA. We measured nestedness using NODF, and we used Betapart to partition Sørenson dissimilarity into nestedness and turnover components. We used linear and generalized linear mixed models to explore drivers of functional group richness and composition, including fire regime (return interval, number of fires, time since fire and seasonality), vegetation structure (herbaceous cover, woody cover and tree density) and spatial factors (surrounding landscape and geographic distance).ResultsWe found turnover‐dominated beta‐diversity patterns in all functional groups. Turnover was explained partly by spatial and environmental gradients, but roughly half of the turnover between sites was unexplained. Species richness was higher on sites where fire and fire surrogates had been used longer and more consistently, and these effects were partly independent of current vegetation structure. Fire regimes containing more growing season fire and more diversity of burn seasons promoted higher species richness. Relationships between small‐scale and large‐scale species richness varied by soil type and functional group.Main conclusionsFire‐maintained savannas in the southeastern NACP vary greatly in their plant functional group richness, but high beta diversity resulting primarily from species turnover suggests that even species‐poor sites can harbour less‐common members of the regional plant metacommunity. Prescribed fire regimes that include growing season fire as well as a diversity of burn seasons may best promote species and functional group richness.
Work ethic and organizational commitment as conditions of unethical pro‐organizational behavior: Do engaged workers break the ethical rules?
Authors: Grabowski Damian , Chudzicka‐Czupała Agata , Chrupała‐Pniak Małgorzata , Mello Abby L. , Paruzel‐Czachura Mariola 
Published: April 2019

AbstractUnethical pro‐organizational behaviors (UPB) are actions that break rules or established standards, but are undertaken for the purposes of helping the organization or coworkers. Although research has already examined the role of work ethic and organizational commitment in shaping employee behaviors, little is known about the reason for and antecedents of employees undertaking UPB. In a sample of 425 working adults from multiple industries, we tested whether work ethic and organizational commitment dimensions predict the readiness to undertake UPB. The time‐lagged study showed that the work ethics dimension “hard work,” and normative and affective organizational commitment, are positive predictors of UPB. The ethics dimensions “morality/ethics,” “delay of gratification,” “centrality of work” and “anti‐leisure attitudes” are negative predictors of UPB.
The influence of political climate on job pursuit intentions and the moderating effect of Machiavellianism
Authors: Djurdjevic Emilija , Rosen Christopher C. , Conroy Samantha A. , Rawski Shannon L. , Sosna Katherine U 
Published: April 2019

AbstractJob seekers now have access to a number of internet resources (e.g., social media, chat rooms, and message boards) that provide information about potential employers. These resources provide potential job applicants with extensive amounts of third‐party information about organizations, including information about the extent to which a particular organization's climate can be characterized as being political. Unfortunately, owing to a dearth of research on this topic, it is unclear to what extent such information about an organization's political climate might affect the recruiting process. Therefore, drawing from the Attraction‐Selection‐Attrition model, we considered the extent to which potential job applicants are less (more) likely to pursue jobs in organizations that are perceived as more (less) political. We further identified Machiavellianism as a potential moderator of this relationship, given that this trait reflects the extent to which an individual would “fit” into a highly political work environment. Across three studies, our findings provide evidence that job applicants report being less likely to pursue jobs in organizations characterized by high levels of workplace politics. The results further indicated that Machiavellianism attenuates this negative effect. In light of our findings, we discuss implications for how information that is not controlled by the organization (e.g., information provided by social media or other internet‐based sources) affects job pursuit intentions and the organization's applicant pool.
Charge compensation mechanisms in Li‐substituted high‐entropy oxides and influence on Li superionic conductivity
Authors: Osenciat Nicolas , Bérardan David , Dragoe Diana , Léridon Brigitte , Holé Stéphane , Meena Arun K. , Franger Sylvain , Dragoe Nita 
Published: April 2019

AbstractThe charge compensation mechanisms that occur when Li+ substitutes a 2+ element in superionic conductor (MgCoNiCuZn)O high‐entropy oxide have been studied using a combination of thermogravimetric analysis and X‐ray photoemission spectroscopy. Depending on the concentration of Li+ in the compound, the charge compensation involves first partial oxidation of Co2+ into Co3+ for low fraction of Li+, and then a combination of both the oxidation of cobalt and the formation of oxygen vacancies for large fraction of Li+.
Body composition patterns and breast cancer risk in Chinese women with breast diseases: A latent class analysis
Authors: Zhang Jinyu , Wang Jichuan , Zhou Jie , Fang Qiong , Zhang Nan , Yuan Changrong 
Published: April 2019

AbstractAimsTo identify unobserved body composition patterns among Chinese women with breast diseases using latent class analysis (LCA) and to examine the relationship between body composition patterns and breast cancer (BC) risk.DesignA descriptive, cross‐sectional study.MethodsFemale patients (N = 1816) with breast diseases were included in the study from April 2016 ‐ March 2017. Body composition measures were done by the bioelectrical impedance analysis. The LCA models were estimated using Mplus 8.1.ResultsFour latent classes were identified based on water, protein, minerals and body fat mass: Class 1 – Low Muscle Mass class; Class 2 – High Body Composition class; Class 3 – High Fat class; and Class 4 – Normal Body Composition Class. Classes 2 and 3 are higher risk classes for developing BC compared with the other two classes (p < 0.05). Overall, age is positively associated with the odds of BC development (p < 0.001). However, age effect depends on the body composition patterns. Age effect on the odds of BC was statistically significant only for women who had least body fat mass (Class 1, OR = 1.110, 95% C.I.: 1.084–1.136) or had normal body composition (Class 4, OR = 1.090, 95% C.I.: 1.036–1.147). The effect of age was not statistically significant if women had higher risk body composition (e.g., in Classes 2 or 3).ConclusionLatent Class Analysis is a useful person‐centred analytical approach for identification of unobserved patterns of body composition and it could be used to predict the risk of BC and develop personalized interventions for body composition studies.