bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior reversible encephalopathy syndrome with spinal cord involvement but without hemisphere lesions
Authors: Liu Lu , Dai Dawei , Cao Fan , Zhang Liming , Wang Xun 
Published: January 2019

Abstract

Rationale
Posterior reversible encephalopathy syndrome (PRES) was termed by Hinchey
[1]
in 1996. Patients have a reversible vasogenic brain edema in imaging and acute neurological symptoms such as headache, seizures, encephalopathy, and visual disturbances when suffering from hypertension, pre-eclampsia/eclampsia, renal failure, immunosuppressive medications, autoimmune disorders, sepsis, thrombocytopaenia, hypocalcaemia, alcohol withdrawal, and many other potential causes.
[2,3]
de Havenon A et al
[4]
have proposed a new syndrome named PRES with spinal cord involvement (PRES-SCI). The patients with PRES-SCI have similar symptoms these of PRES. Patients have neurologic signs with the spinal cord involved and lesions in magnetic resonance imaging (MRI) extending to the cervicomedullary junction, usually with extreme elevation in blood pressure and a history of hypertensive retinopathy.
[4]
We administrated a young patient whose condition was consistent with PRES-SCI except for the hemisphere lesions.

Patient Concerns
A 20-year-old Asian male patient was admitted for a 1 week history of blurred vision and weakness of the limbs. He has had poorly controlled hypertension for 1 year before admission. In emergency room, his blood pressure could raise to 260/140mmHg. Neurological examinations and cerebral spinal fluid tests were negative. The MRI of the brain and spinal cord showed reversible lesions in the medulla and upper cervical spinal cord that extended to the lower thoracic spine.

Diagnosis
Taking into account the characteristic lesions in the MRI as well as the reversible course upon treatment, he was diagnosed PRES-SCI.

Interventions
He was treated with medicines for the hypertension.

Outcomes
His symptoms rapidly improved and finally the lesions on the MRI of the brain and spianl cord disappeared.

Lessons
Clinicians should suspect PRES-SCI when patients have mild or no neurologic signs accompanied with extreme elevation in blood pressure and lesions in spinal cord. Spinal lesions alone may be a subtype of PRES-SCI.
Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease
Authors: Yuepeng Jiang , Zhao Xiaoxuan , Zhao Yang , Li Liu 
Published: January 2019

Abstract
To evaluate the association between gene polymorphisms of TNF-α G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.
We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12.0 software.
Thirty-five articles were included. Among them, 17 studies were related to TNF-α (G308A) gene mutation and CHD, and 18 studies examined IL-6 (C174G) gene mutation. According to the results of subgroup analysis of ethnicity, it suggested that TNF-α (G308A) polymorphism was not significantly associated with CHD risk under all models in Asians (P > .05). There were no connected of IL-6 C174G polymorphism with CHD risk under all models in Caucasians after subgroup analysis (P > .05).
The present evidence shows that TNF-α (G308A) have no connected with the risk of CHD in Asians; IL-6 (C174G) gene were not associated with the risk of CHD in Caucasians.
Different treatments for acute myocardial infarction patients via outpatient clinics and emergency department
Authors: Chien Ching-Wen , Wang Cheng-Hua , Chao Zi-hao , Huang Song-Kong , Chen Pei-En , Tung Tao-Hsin 
Published: January 2019

Abstract
To investigate relevant factors and patients with acute myocardial infarction (AMI) were admitted during between weekdays and weekends period.
Retrospective population-based study setting: from the 2005 population-based national health insurance underwriting database of millions of people, random sampling (National Health Insurance Research Database [NHIRD]-Longitudinal Health Insurance Database [LHID] 2005).
In 2000 to 2009 data of NHIRD, subjects presented with first episode AMI who had received the thrombolytic therapy (TPA), or percutaneous coronary artery intervention (PTCA) or coronary artery bypass graft (CABG) during between weekdays and weekends period.
From 2000 to 2009 among patients with first AMI total of 2007 people, the weekday group 1453 people, the weekend group 554. The total mortality within 1 year showed 33.53%, the first-day mortality occupied 8.07% in 1 year of total mortality, increased mortality after admission 3 months later. Cox regression analysis showed that AMI has presented significant risk of death, there are 4 items: weekends, age, Charlson comorbidity index (CCI), thrombolytic therapy; in the other variables including emergency, hospital level, hospital ownership, and urban-rural gap are not significant differences. Further using hierarchical logistic regression analysis for Stratification of AMI mortality risk, it has significant that showed the hospital level, age, CCI, thrombolytic therapy; but emergency, PTCA and 3 CABG treatment are not significant differences.
It was approved by the hierarchical logistic regression analysis after stratified correction that the present study will have a direct impact on weekdays and weekends death in the hospital level. It will also affect the individual level.
A novel application of B-ultrasonography at various head positions in the diagnosis of untypical uveitis-glaucoma-hyphema (UGH) syndrome
Authors: Wu Nianlang , Zhang Huicheng , Chen Bin , Ding Wenting 
Published: January 2019

Abstract

Rationale:
Uveitis-glaucoma-hyphema (UGH) syndrome could be identified by conventional ultrasound biomicroscopy (UBM) and B-ultrasonography, but failed in some untypical cases. We introduced a novel application of B-ultrasonography in diagnosis of UGH syndrome in a rare case.

Patient concerns:
A 60-year-old woman was referred for distending pain with blurred vision for more than 1 month in the right eye after cataract surgery.

Diagnoses:
B-ultrasound scanner and UBM demonstrated the Intraocular Lens (IOL) was centered in the bag. No chafing in all directions was detected between IOL and iris/ciliary body. The proposed diagnoses were iridocyclitis and secondary glaucoma of the right eye.

Interventions:
The symptoms were not improved after antiinflammation and intraocular pressure (IOP) lowering treatment for 1 month. B-ultrasonography was applied in horizontal, sitting, and head-down positions. The results demonstrated movements of IOLs when position changed. The IOLs were in contact with the iris pigment epithelium in sitting position and head-down positions but not in horizontal position. The dynamic interactions between IOLs and iris/ciliary body implied a diagnosis of UGH syndrome. The IOLs were then extracted.

Outcomes:
Two weeks after the IOLs explantation, the IOP significantly reduced to a normal level in both eyes. Ten-month follow-up showed that the IOP was maintained at a normal level.

Lessons:
The chronically intermittent chafing between IOL and iris in specific head positions would also lead to UGH syndrome. Dynamic application of B-ultrasonography in various head positions could be useful in the diagnosis of an untypical UGH syndrome.
Complex pulmonary arteriovenous fistula in mother and daughter
Authors: Zhang Xin , Zheng Mingxia , Li Xingjian , Yan Yejun , Yang Caixia , Zhao Zhengang , Feng Yuan , Chen Mao 
Published: January 2019

Abstract

Rationale:
Complex pulmonary arteriovenous fistula (PAVF) is unusual, and even rarer in 2 members of a family. PAVF may not appear on chest X-ray or computed tomography imaging, especially in asymptomatic patients, and therapy is limited. Herein, PAVFs occurring in a mother and daughter are described, with the current standard methods of diagnosis and treatment of PAVF.

Patient concerns:
A 34-year-old woman and her 13-year-old daughter presented with light cyanosis of the nail beds but were otherwise asymptomatic, and physical examination was unremarkable. Their arterial oxygen saturation levels were low (80–85%).

Diagnoses:
Angiography led to a diagnosis of PAVF involving the bilateral lung in both women.

Interventions:
The combined use of coils with occluder (patent ductus arteriosus, or PDA) to obstruct the fistula.

Outcomes:
After interventional treatment, the patients’ arterial oxygen saturation improved rapidly (90–95%). At 6-month follow-up, the patients’ symptoms and oxygen saturation were normal.

Lessons:
PAVF is an autosomal dominant disease. Here, the characteristics of the 2 patients were very similar. Using detachable coils and then a PDA occluder is a highly efficient method for treating complex PAVFs.
The correlation between affected renal function and affected renal residual volume
Authors: Chen Fang-Min , Hu Rui-Jie , Jiang Xi-Nan , Zhong Si-Wen , Tang Shuai 
Published: January 2019

Abstract
Laparoscopic nephron-sparing partial nephrectomy with segmental renal artery blocking (SRPN) has been widely used in the treatment of localized renal tumors. However, the impact of ischemia-reperfusion injury (IRI) during SRPN remains controversial. This study aims to evaluate the correlation between affected renal function and affected renal volume after SRPN for localized renal tumor treatment, explore the effect of IRI on renal function after SRPN.
A total of 39 patients who underwent SRPN for localized renal tumor from June 2009 to April 2012 were reviewed. These patients were followed-up for 5 years. The preoperative affected renal glomerular filtration rate (aGFRpre), postoperative affected renal glomerular filtration rate (aGFRpost), preoperative affected renal volume (aVolpre), and postoperative affected renal volume (aVolpost) were collected during the follow-up period. The correlation between aGFRpost/aGFRpre and aVolpost/aVolpre was compared.
A total of 33 patients were successfully followed up. After 3, 6, 12, 24, and 60 months, aGFRpost was 34.6 ± 4.6, 34.7 ± 4.8, 34.9 ± 4.4, 35.1 ± 4.4, and 35.2 ± 4.2 mL/min. The correlation coefficients between aGFRpost/aGFRpre and aVolpost/aVolpre were 0.659 (P = .000), 0.667 (P = .000), 0.663 (P = .000), 0.629 (P = .000), and 0.604 (P = .000), respectively. The limitation of this study was the small cohort size.
For the localized renal tumor, aGFRpost was associated with aVolpost, but was not associated with intraoperative factors, such as the time of clamping of the affected segmental renal artery. As a part of nephrons, the resected tumor tissue caused the lack of inherent nephrons, resulting in the loss of renal function. More nephrons should be maintained before resecting the tumor completely during SRPN.
Trial registration: ChiCTR-RRC-17011418.
Human papilloma virus identification in ocular surface squamous neoplasia by p16 immunohistochemistry and DNA chip test
Authors: Shrestha Tina , Choi Won , Kim Ga Eon , Yang Jee Myung , Yoon Kyung Chul 
Published: January 2019

AbstractThe aim of this study was to identify the association between human papilloma virus (HPV) infection and ocular surface squamous neoplasia (OSSN) usingp16 immunohistochemistry (IHC) and deoxyribonucleic acid (DNA) chip test.Thirty-eight patients who underwent surgical excision of OSSN were retrospectively studied using tissue samples. The IHC was performed to assess the expression ofp16 and DNA chip test was used to detect 24 HPV serotypes.Among the 38 OSSN samples, 32 cases (84.2%) were histopathologically categorized as pre-invasive type and 6 cases (15.8%) as invasive type. The IHC forp16 showed strong positivity in 12 cases (31.6%), whereas it was negative in 26 cases (68.4%). On the other hand, only one case (2.6%) of invasive OSSN was positive for the HPV16 serotype, as assessed by DNA chip test.In OSSN,p16 expression was positive in approximately 1/3rd of the cases, whereas the majority of the 24 HPV serotypes were negative forp16. Our findings suggest that only a weak association exists between HPV infection and OSSN.
The association of depression following percutanous coronary intervention with adverse cardiovascular events
Authors: Liu Yanfei , Zhao Yinke , Tian Jinfan , Tong Tiejun , Gao Rui , Liu Yue 
Published: January 2019

Abstract

Introduction:
Percutanous coronary intervention (PCI) has been increasingly used for patients suffered from severe coronary artery disease. However, physical trauma and potential adverse events related to the procedure often result in detrimental psychological stress. Accumulating evidences have shown that depression is closely related to coronary artery disease. However, the association of depression following percutanous coronary intervention with adverse cardiovascular events is still unknown.

Objective:
This review is designed to assess the prognostic association of depression following PCI with adverse cardiac events.

Methods and analysis:
The following databases will be searched, PubMed, the EMBASE, CINAHL and Web of Science of English-language publications from inception to 30 October 2018. Cross-referencing from retrieved studies will be conducted additionally, and observational studies were included. Two independent review authors will do the study selection on the basis of the study eligibility criteria. Extracted data will be used for quantitative and qualitative evidence synthesis as well as to assess methodological quality of studies using the Newcastle-Ottawa checklist. The primary objective of this review is adverse cardiac events, presented as a composition of myocardial infarction, repeat coronary revascularization, cardiac readmission, and cardiac death. The accumulated evidence is evaluated and graded according to Grading of Recommendations, Assessment, Development and Evaluation (GRADE).

Results and conclusions:
This review will explain the association of depression following percutanous coronary intervention with adverse cardiovascular events, and provide physicians with scientific evidence for psychological intervention in patients after PCI.

Prospero registration number:
CRD42018112486.
Intraoperative hypothermia is a significant prognostic predictor of radical cystectomy especially for stage II muscle-invasive bladder cancer
Authors: Morozumi Kento , Mitsuzuka Koji , Takai Yuki , Katsumata Yuki , Kuromoto Akito , Hoshi Senji , Numahata Kenji , Arai Yoichi 
Published: January 2019

Abstract
The objective of this study was to evaluate intraoperative hypothermia as a predictor of complication and prognosis in patients with muscle-invasive bladder cancer treated with radical cystectomy.
The data of 124 patients treated with radical cystectomy for muscle-invasive bladder cancer in our department, from 2003 to 2016, were retrospectively collected. The patients were divided into 2 groups according to the lowest intraoperative deep body temperature, that is, the hypothermia group (<96.8°F) and the normothermia group (≥96.8°F). Preoperative and intraoperative variables were compared among the 2 groups, and factors associated with complications, recurrences, and survivals were analyzed.
Sixty-eight (54.8%) of the 124 patients presented intraoperative hypothermia. There was no significant difference in the patient's characteristics between the 2 groups. Postoperative complications (Clavien–Dindo ≤III) of any types occurred in 15 patients (22.1%) in the hypothermia group, as compared with 8 patients (14.3%) in the normothermia group (P = .27). The hypothermia group had a higher pathologic stage (P = .029) and a higher recurrence rate within 12 months (P = .013), as compared with the normothermia group. Intraoperative hypothermia was an independent prognostic factor for overall survival in all patients (hazard ratio [HR] 2.47; 95% confidence interval [CI], 1.01–2.85; P = .047). When stratified by disease stage, stage II intraoperative hypothermia was an independent prognostic factor for disease-free survival (HR 3.35; 95% CI, 1.27–8.83; P = .015) and overall survival (HR 4.24; 95% CI, 1.38–12.9; P = .011).
This study suggests that intraoperative hypothermia could be a significant predictor for recurrence and survival in muscle-invasive bladder cancer treated with radical cystectomy.
The influence of pelvis reposition exercises on pelvic floor muscles asymmetry
Authors: Oleksy Łukasz , Mika Anna , Kielnar Renata , Grzegorczyk Joanna , Marchewka Anna , Stolarczyk Artur 
Published: January 2019

Abstract

Objective:
The assessment of pelvis reposition exercise efficacy in the treatment of pelvic floor muscles (PFM) asymmetry. The hypothesis was that PFM asymmetry may have a functional reason related to lumbopelvic complex misalignment.

Design:
A parallel group trial with follow-up

Methods:
Thirty young women were divided into 2 groups: experimental (n = 15) and control (n = 15). In experimental group one, a 15-minute trial of pelvis reposition exercise was carried out. Ober test, the Thomas test, and transabdominal PFM ultrasound measurements were performed in both groups.

Results:
In the experimental group both the Ober and Thomas tests were positive at baseline in most subjects. After the exercise, improvement was noted in Ober test (P = .005; d = 0.75 on the right side, P = .005; d = 0.78 on the left side) and in the Thomas test (P = .005; d = 0.66 on the right side, P = .005; d = 0.67 on the left side). At baseline, the ultrasonographic evaluation of PFM performed during resting and during voluntary pelvic muscles contraction showed the right–left length asymmetry. The return of symmetrical PFM work after pelvis reposition exercise was observed in the experimental group. There were no statistically significant changes in the control group.s

Conclusions:
We suggest that after reposition exercises, the pelvis was more symmetrically aligned in relation to body axis; therefore, the muscles of the pelvic floor have functional length and did not shorten or lengthen due to pelvis rotation. In this study, for the first time, it was presented that PFM asymmetry visible in ultrasonography may be corrected by this specific exercise. Further analysis of the causes of this asymmetry may lead to more accurate treatment of PFM dysfunctions.
Septic patients presenting with apparently normal C-reactive protein
Authors: Wasserman Asaf , Karov Ruth , Shenhar-Tsarfaty Shani , Paran Yael , Zeltzer David , Shapira Itzhak , Trotzky Daniel , Halpern Pinchas , Meilik Ahuva , Raykhshtat Eli , Goldiner Ilana , Berliner Shlomo , Rogowski Ori 
Published: January 2019

Abstract
The presentation of septic patients with low C-reactive protein (CRP) concentrations to the emergency room (ER) might convey an erroneous impression regarding the severity of the disease.
We analyzed a retrospective study of septic patients admitted to the internal medicine departments of a relatively large tertiary medical center, following admission to the ER. These patients had CRP concentrations of <31.9 mg/L, the determined cut-off for CRP concentrations in a large cohort of apparently healthy individuals in the community (n = 17,214, upper limit of mean + 3 standard deviations).
By processing the electronic medical records, we found 2724 patients with a diagnosis of sepsis, 476 of whom had an admission CRP concentration of <31.9 mg/L. Following further analysis of these records, we found that 34 of the 175 patients (19.4%) who fulfilled the definition of sepsis, died within 1 week of hospitalization. Of special interest was the finding that within <24 h, a significant increment from a median CRP of 16.1 mg/L (IQR 7.9–22.5) to 58.6 mg/L (IQR 24.2–134.4), (P < .001) was noted, accompanied by a velocity change from 0.4 ± 0.29 to 8.3 ± 24.2 mg/L/h following antibiotic administration (P < .001).
ER physicians should take into consideration that septic patients with a high in-hospital mortality rate can present with CRP concentrations that are within the range observed in apparently healthy individuals in the community. A second CRP test obtained within 24 h following antibiotic administration might influence attitudes regarding the severity of the disease.
The genetic association between EGF A61G polymorphism (rs4444903) and risk of colorectal cancer
Authors: Zhu Yi , Chen ZhiHeng , Jiang HongGang , Lu BoHao 
Published: January 2019

Abstract

Background:
Colorectal cancer was a complex disease with multiple causative factors including genetic and environmental factors, as well as the interaction of the 2 factors. Relationship between epidermal growth factor (EGF) A61G polymorphism and colorectal cancer risk has been widely investigated previously, whereas results derived from these studies were inconclusive and controversial. The aim of this study was to investigate the association between the EGF A61G polymorphism and colorectal cancer using a meta-analysis of existing literature.

Methods:
Literature search was conducted from PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang, and Cochrane library databases before July 2017. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between EGF A61G and colorectal cancer.

Results:
A total of 9 studies that involved 1448 cases and 1928 healthy controls and found allelic (OR = 1.18, P = .04) and recessive models (OR = 1.36, P = .03) of EGF A61G were significantly associated with the risk of colorectal cancer. Stratification analyses by ethnicity indicated that the EGF 61G significantly increased the risk of colorectal cancer in the Caucasian subgroup (OR = 1.24, P = .02), but not in Asian subgroup (OR = 1.12, P = .08). And the frequency of GG genotype of EGF A61G significantly increased in cases than that in healthy controls in both Caucasian (OR = 1.40, P = .04) and Asian subgroups (OR = 1.27, P = .01). Furthermore, the sample sources and genotyping methods seem to have no influence on the correction of EGF A61G and colorectal cancer susceptibility (P > .05).

Conclusion:
The results indicate that EGF A61G might increase the risk of colorectal cancers.