bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silver in Wound Care—Friend or Foe?: A Comprehensive Review
Authors: Khansa Ibrahim , Schoenbrunner Anna R. , Kraft Casey T. , Janis Jeffrey E. 
Published: August 2019

Background:
Due to its strong antimicrobial activity, silver is a commonly used adjunct in wound care. However, it also has the potential to impair healing by exerting toxic effects on keratinocytes and fibroblasts. The published literature on the use of silver in wound care is very heterogeneous, making it difficult to generate useful treatment guidelines.

Methods:
A search of high-quality studies on the use of silver in wound care was performed on PubMed. A detailed qualitative analysis of published articles was performed to evaluate the evidence for the use of silver in infected wounds, clean wounds, burns, and over closed surgical incisions.

Results:
Fifty-nine studies were included in this qualitative analysis. We found that, overall, the quality of the published research on silver is poor. While there is some evidence for short-term use of dressings containing nanocrystalline silver in infected wounds, the use of silver-containing dressings in clean wounds and over closed surgical incisions is not indicated. Negative-pressure wound therapy accelerates the healing of contaminated wounds, especially when silver is used as an adjunct. For burns, silver sulfadiazine slows healing and should not be used. Instead, nanocrystalline silver, or alternatives such as octenidine and polyhexanide, lead to less infection and faster healing.

Conclusions:
In infected wounds, silver is beneficial for the first few days/weeks, after which nonsilver dressings should be used instead. For clean wounds and closed surgical incisions, silver confers no benefit. The ideal silver formulations are nanocrystalline silver and silver-coated polyurethane sponge for negative-pressure wound therapy. Silver sulfadiazine impairs wound healing. Proper use of silver-containing dressings is essential to optimize wound healing.
Systematic Review and Meta-Analysis of the Medium- and Long-Term Outcomes of the Boston Type 1 Keratoprosthesis
Authors: Priddy Jack , Bardan Ahmed Shalaby , Tawfik Hadeel Sherif , Liu Christopher 
Published: August 2019

Purpose:
The Boston type 1 keratoprosthesis (KPro), used in patients with high risk of corneal graft failure, is increasingly being used. However, the medium- to long-term outcomes are currently unclear. We analyzed the medium- (2–5 years) and long-term (>5 years) efficacy and safety of the Boston type 1 KPro in terms of visual outcomes, device retention, and postoperative complications.

Methods:
We last searched electronic databases (Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid MEDLINE Epub Ahead of Print, EMBASE, and CENTRAL) on March 31, 2018. Visual outcomes and device retention at 2 and 5 years, alongside postoperative complications, were primary outcome measures.

Results:
We identified 407 articles. Thirty studies were included in this systematic review and meta-analysis. The combined proportion of eyes with ≥6/60 vision was 62% at 2 years and 51% at 5 years. The combined retention rate was 88% at 2 years and 74% at 5 years. Retroprosthetic membrane (36.6%) and glaucoma (39.3%) were found to be the most common long-term complications. Very few studies showed visual outcomes or retention rates at 5 years, with results sparse and collectively not meaningful because of small patient numbers and ambiguous reporting of follow-up times.

Conclusions:
The 2-year results indicate that there is a place for the Boston type 1 KPro in the management of corneal blindness. However, there is scarce evidence regarding its medium- and long-term efficacy and safety. The high rate of reported complications necessitates strict patient selection and stringent follow-up.
Cenegermin in Pediatric Neurotrophic Keratopathy
Authors: Pedrotti Emilio , Bonetto Jacopo , Cozzini Tiziano , Fasolo Adriano , Marchini Giorgio 
Published: August 2019

Purpose:
We report a case of neurotrophic keratopathy (NK) arising after surgery for rhabdomyosarcoma of the jaw successfully treated with Cenegermin eye drops (Oxervate; Dompé Farmaceutici, Milan, Italy) in a 3-year-old boy.

Methods:
At the age of 1 year, the boy underwent surgery for rhabdomyosarcoma of the jaw, followed by radiotherapy. Subsequent NK was initially treated with preservative-free artificial tears, topical combination of dexamethasone 0.1% and netilmicin 0.3% (Netildex; Sifi, Catania, Italy), and moxifloxacin 0.5% (Vigamox; Alcon, Fort Worth, TX), followed by 10 cycles of a topical eye biopolymer containing a poly-carboxymethyl glucose sulfate solution (Cacicol; Theà, Clermont-Ferrand, France) and 4 amniotic membrane transplantations. Keratopathy was recalcitrant to therapy and tissue transplant. Therapy was switched to Cenegermin eye drops 6 times daily for 8 weeks.

Results:
Complete healing of the corneal epithelium was achieved at 3 weeks into treatment.

Conclusions:
Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK.
Management of pancreatic fluid collections in patients with acute pancreatitis
Authors: Mahapatra Soumya J. , Garg Pramod K. 
Published: August 2019

Abstract
Acute pancreatitis is associated with development of pancreatic fluid collections (PFCs). Acute PFCs that develop in interstitial edematous pancreatitis mostly resolve but some may persist and evolve into pseudocysts. Acute necrotic collections occurring in acute necrotizing pancreatitis generally persist and evolve into walled-off necrosis (WON) after 3 to 4 weeks. Most acute fluid collections do not require drainage unless they are large and cause compression of adjacent organs, contribute to increase in intraabdominal pressure or become infected. Acute infected collections can be managed with antibiotics and percutaneous drainage but may require necrosectomy either by minimally invasive surgical or endoscopic methods such as video-assisted retroperitoneal debridement and percutaneous endoscopic necrosectomy. Mature sterile collections, that is, pseudocyst and WON with a defined wall are best treated by internal transmural drainage which can be achieved either by per-oral endoscopic or surgical, preferably laparoscopic, method. Of late, infected PFCs are increasingly being treated with an endoscopic step-up approach that has been shown to be better than minimally invasive surgical step-up approach in terms of lesser complications. Use of lumen apposing metal stents during endoscopic drainage has emerged as an attractive option that facilitates necrosectomy in infected WON.
Preliminary Analysis From the Craniofacial Collaboration United Kingdom Developmental Outcomes in Children With Sagittal Synostosis
Authors: Care Helen , Kennedy-Williams Patrick , Cunliffe Alexandra , Denly Susie , Horton Jo , Kearney Anna , Knapp Maria , O’Leary Gemma , Piggott Katie , Pinckston Molly , Rooney Natasha , Thomas Siân , Dalton Louise 
Published: August 2019

Abstract
The Craniofacial Collaboration United Kingdom (CC-UK) was established across the 4 Highly Specialized Craniofacial Centres (HSCCs) in the UK in 2015. This is the first wave of data to be analyzed, looking at 3-year-old children with sagittal synostosis who have had primary corrective surgery. This is a comprehensive, homogenous dataset, looking at parental measures of development and behavior. The results indicate that the majority of children are rated by their parents as falling within one standard deviation of the mean for both developmental and behavioral measures. However, there was a trend across the age groups within the sample which, although not statistically significant, indicates that more developmental difficulties may become apparent as children get older. Behavior was rated as more problematic, and the areas of greatest parental concern were Conduct (challenging or confrontational behavior) and Hyperactivity domains, where 24% of children were rated as within the clinically significant range. Although the majority of children were rated as falling within the average range, the difference in the mean between the sagittal and the normative group was significant in 5 of the 6 behavioral domains. Further research is required to examine whether these findings are stable over time and to look at the mechanism which might be driving these changes. It is anticipated that future CC-UK analysis will elucidate this more clearly.
Anthropometric Analysis of Secondary Cleft Lip Rhinoplasty Using Costal Cartilage Graft
Authors: Talaat Wael M. , Ghoneim Mohamed M. , El-Shikh Yasser M. , Elkashty Sherif I. , Ismail Mohammed A.G. , Keshk Tarek F.A. 
Published: August 2019

AbstractDespite the improvement of primary repair of nasal deformities during the management of cleft lip in infancy, this does not exclude the need for revision rhinoplasty in adulthood for complete patients’ rehabilitation. The purpose of this study was to evaluate the aesthetic outcome of secondary rhinoplasty using costal cartilage grafts in patients with unilateral cleft lip nasal deformity. Twenty patients who were operated at earlier ages for correction of cleft lip and had a residual unilateral cleft lip nasal deformity were included in this study. Costal cartilage rib grafts were harvested; carved and used for maxillary augmentation, columellar strut graft, and lateral crural strut graft. Five anthropometric measurements (nostril height, width and gap area, columellar axis deviation angle and nasal base inclination angle) were used for evaluation of aesthetic results. The ratio of nostril width, height and gap area between the cleft side and the non-cleft side showed significant improvement (P<0.05). The columellar axis deviation showed significant improvement towards the midline (P= 0.004), and the alar base inclination showed improvement towards the horizontal line (P= 0.0045). In conclusion, the aesthetic outcomes of secondary cleft lip rhinoplasty using the costal cartilage are satisfactory. The costal cartilage has the required strength, is easily carved and maintains shape for considerable time.
Circulating B Cells With Memory and Antibody-Secreting Phenotypes Are Detectable in Pediatric Kidney Transplant Recipients Before the Development of Antibody-Mediated Rejection
Authors: Fischman Clara , Fribourg Miguel , Fabrizio Ginevri , Cioni Michela , Comoli Patrizia , Nocera Arcangelo , Cardillo Massimo , Cantarelli Chiara , Gallon Lorenzo , Petrosyan Astgik , Da Sacco Stefano , Perin Laura , Cravedi Paolo 
Published: August 2019

Background.
Development of anti–human leukocyte antigen donor-specific antibodies (DSAs) is associated with antibody-mediated rejection (AMR) and reduced allograft survival in kidney transplant recipients. Whether changes in circulating lymphocytes anticipate DSA or AMR development is unclear.

Methods.
We used time-of-flight mass cytometry to analyze prospectively collected peripheral blood mononuclear cells (PBMC) from pediatric kidney transplant recipients who developed DSA (DSA-positive recipients [DSAPOS], n = 10). PBMC were obtained at 2 months posttransplant, 3 months before DSA development, and at DSA detection. PBMC collected at the same time points posttransplant from recipients who did not develop DSA (DSA-negative recipients [DSANEG], n = 11) were used as controls.

Results.
DSAPOS and DSANEG recipients had similar baseline characteristics and comparable frequencies of total B and T cells. Within DSAPOS recipients, there was no difference in DSA levels (mean fluorescence intensity [MFI]: 13 687 ± 4159 vs 11 375 ± 1894 in DSAPOSAMR-positive recipients (AMRPOS) vs DSAPOSAMR-negative recipients (AMRNEG), respectively; P = 0.630), C1q binding (5 DSAPOSAMRPOS [100%] vs 4 DSAPOSAMRNEG [80%]; P = 1.000), or C3d binding (3 DSAPOSAMRPOS [60%] vs 1 DSAPOSAMRNEG [20%]; P = 0.520) between patients who developed AMR and those who did not. However, DSAPOS patients who developed AMR (n = 5; 18.0 ± 3.6 mo post-DSA detection) had increased B cells with antibody-secreting (IgD−CD27+CD38+; P = 0.002) and memory (IgD-CD27+CD38−; P = 0.003) phenotypes compared with DSANEG and DSAPOSAMRNEG recipients at DSA detection.

Conclusions.
Despite the small sample size, our comprehensive phenotypic analyses show that circulating B cells with memory and antibody-secreting phenotypes are present at DSA onset, >1 year before biopsy-proven AMR in pediatric kidney transplant recipients.
Evaluation of Reproducible and Transparent Research Practices in Pulmonology Publications
Authors: Smith Caleb A. , Nolan Johnny , Tritz Daniel J. , Heavener Trace E. , Pelton Jameson , Cook Kathy , Vassar Matt 
Published: August 2019

AbstractRationaleStudy reproducibility is valuable for validating or refuting results. Provision of reproducibility indicators, such as materials, protocols, and raw data in a study to improve its potential for reproduction. Efforts to reproduce noteworthy studies in the biomedical sciences have resulted in an overwhelming majority of them being found to be unreplicable, causing concern for the integrity of research in other fields, including medical specialities.ObjectiveHere, we analyzed the reproducibility of studies in the field of pulmonology.Methods300 pulmonology articles were randomly selected from an initial PubMed search for data extraction. Two authors scoured these articles for reproducibility indicators including materials, protocols, raw data, analysis scripts, inclusion in systematic reviews, and citations by replication studies as well as other factors of research transparency including open accessibility, funding source and competing interest disclosures, and study preregistration.Main ResultsFew publications included statements regarding materials (11%), protocols (1%), data (21%), and analysis script (0%) availability. Less than 10% indicated preregistration. More than half of the publications analyzed failed to provide a funding statement. Conversely, 66% of the publications were open access and 70% included a conflict of interest statement.ConclusionOverall, our study indicates pulmonology research is currently lacking in efforts to increase replicability. Future studies should focus on providing sufficient information regarding materials, protocols, raw data, and analysis scripts, among other indicators, for the sake of clinical decisions that depend on replicable or refutable results from the primary literature.
Epigenetics biomarkers of delirium: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients
Authors: Saito Taku , Toda Hiroyuki , Duncan Gabrielle N. , Jellison Sydney S. , Yu Tong , Klisares Mason J. , Daniel Sophia , Andreasen Allison , Leyden Lydia , Hellman Mandy , Shinozaki Eri , Lee Sangil , Yoshino Aihide , Cho Hyunkeun R. , Shinozaki Gen 
Published: August 2019

ABSTRACTBackgroundThe authors previously hypothesized the role of epigenetics in pathophysiology of delirium, and tested DNA methylation (DNAm) change among pro-inflammatory cytokines along with aging in blood, glia and neuron. The authors reported that DNAm level of the TNF-alpha decreases along with aging in blood and glia, but not in neuron; however, DNAm differences between delirium cases and non-delirium controls have not been investigated directly. Therefore, in the present study, DNAm differences in blood between delirium patients and controls without delirium were examined.MethodsA case-control study with 92 subjects was conducted. Whole blood samples were collected and genome-wide DNAm was measured by the Infinium HumanMethylationEPIC BeadChip arrays. The correlation between DNAm levels in the TNF-alpha and age, network analysis, and the correlation between age and DNAm age were tested.ResultsOnly delirium cases showed 3 CpGs sites in the TNF-alpha significantly correlated to age after multiple corrections. A genome-wide significant CpG site near the gene of LDLRAD4 was identified. In addition, network analysis showed several significant pathways with false discovery rate adjusted p-value < 0.05. The top pathway with GO was immune response, and the second top pathway with KEGG was cholinergic synapse. Although there was no statistically significant difference, DNAm age among non-delirium controls showed “slower aging” compared to delirium cases.ConclusionsDNAm differences were shown both at gene and network levels between delirium cases and non-delirium controls. This finding indicates that DNAm status in blood has a potential to be used as epigenetic biomarkers for delirium.
Oxidation kinetics of nanocrystalline Al thin films
Authors: Luo Jinsong , Zhang Ligong , Yang Haigui , Zhang Nan , Zhu Yongfu , Liu Xingyuan , Jiang Qing 
Published: August 2019

PurposeThis paper aims to study the oxidation kinetics of the nanocrystalline Al ultrathin films. The influence of structure and composition evolution during thermal oxidation will be observed. The reason for the change in the oxidation activation energy on increasing the oxidation temperature will be discussed.Design/methodology/approachAl thin films are deposited on the silicon wafers as substrates by vacuumed thermal evaporation under the base pressure of 2 × 10−4 Pa, where the substrates are not heated. A crystalline quartz sensor is used to monitor the film thickness. The film thickness varies in the range from 30 to 100 nm. To keep the silicon substrate from oxidation during thermal oxidation of the Al film, a 50-nm gold film was deposited on the back side of silicon substrate. Isothermal oxidation studies of the Al film were carried out in air to assess the oxidation kinetics at 400-600°C.FindingsThe activation energy is positive and low for the low temperature oxidation, but it becomes apparently negative at higher temperatures. The oxide grains are nano-sized, and γ-Al2O3crystals are formed at above 500°C. In light of the model by Davies, the grain boundary diffusion is believed to be the reason for the logarithmic oxidation rate rule. The negative activation energy at higher temperatures is apparent, which comes from the decline of diffusion paths due to the formation of the γ-Al2O3crystals.Originality/valueIt is found that the oxidation kinetics of nanocrystalline Al thin films in air at 400-600°C follows the logarithmic law, and this logarithmic oxidation rate law is related to the grain boundary diffusion. The negative activation energies in the higher temperature range can be attributed to the formation of γ-Al2O3crystal.
Visible and invisible borders in time and space
Authors: Healy Geraldine 
Published: August 2019

Purpose
The purpose of this paper is to explore how biography influences professional and academic development. It aims to show how in different ways our experiences reflect the structures of society and that histories repeat themselves with different protagonists and different preys. It uses the author’s own biography to argue that in the author’s case, early influences of Irish migration shaped some of the decisions she made and her commitment to researching inequalities. The paper also asks how relevant are early life influences on the careers of equality and diversity academics?

Design/methodology/approach
This paper uses a biographical method that draws on a personal history of migration and relates these to historical moments to show the interconnection between the self and wider macro events.

Findings
The findings of the paper show the relevance and interconnection of biography with the macro and political context. The paper explores how an academic's personal biography[1] and the multi-layered relationship between the self and the wider macro historical context have influenced her research development. It does this by using her personal stories of being part of an Irish community and shows how everyday interactions may lead to a sense of being an outsider, of being other. History is used to show the multiple borders that Irish and other migrants experience, from biographic and diasporic borders, to violence and conflict and finally to work borders including the link with the author's research work. The paper argues that while the targets of discrimination may change over time, contemporary events can intensify the devaluation and othering of particular migrant groups.

Originality/value
Each biography has a unique element but the paper shows how individual biographies are connected and interrelated with the macro level of analysis.
Mediating model of brand equity and its application
Authors: Raut Umesh Ramchandra , Pawar Prafulla Arjun , Brito Pedro Quelhas , Sisodia Gyanendra Singh 
Published: August 2019

PurposeThis paper aims to examine the mediating role of brand satisfaction and brand trust in brand equity antecedents and outcomes through an empirical investigation of brand equity elements.Design/methodology/approachA survey was conducted in Pune and Mumbai, two prominent cities of India. A structured questionnaire focussed on garnering responses on measuring brand equity antecedents and outcomes was circulated to the cell phone users. The questionnaire aimed to assess the role of two additional variables, namely, brand satisfaction and brand trust, in the existing and the conceptual model of brand equity (Keller, 2001). Based on the data analysis, a structural equations path and the mediating model were developed.FindingsThe findings of this study show that the new brand equity model is highly relevant in predicting brand equity as compared to the existing brand equity model (Keller, 2001). The brand equity mediation model clearly elucidates the role of brand trust and brand satisfaction.Research limitations/implicationsWith reference to a theoretical contribution, the study broadens the existing hypothetical model of brand equity. The findings of this research provide a strategic and analytical model for brand managers to build brand relationships among their consumers.Originality/valueThe present study challenges the existing model of brand equity (Keller, 2001) and further makes an effort to fill in the gaps in the existing theoretical model of brand equity.
Insulin‐like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non‐alcoholic fatty liver disease
Authors: Yan Hua , Li Ting , Wang Yatao , Li Hong , Xu Jingyuan , Lu Xiaolan 
Published: August 2019

AbstractAn association between increased insulin‐like growth factor binding protein‐7 (IGFBP7) expression and insulin resistance in metabolic diseases has been reported. However, the role and molecular mechanism of IGFBP‐7 in non‐alcoholic fatty liver disease (NAFLD) remains largely unknown. Therefore, the potential function of IGFBP7 in the pathological progression of NAFLD was explored in this investigation. For in vivo experiments, an animal model of NAFLD was established in C57BL/6 mice by feeding a high‐fat diet (HFD), and IGFBP7 was knocked down by injecting adeno‐associated adenovirus (AAV)‐mediated short‐hairpin (sh)‐IGFBP7 into the liver. We found that AAV‐sh‐IGFBP7 treatment significantly alleviated hepatocyte injury and inhibited hepatic lipid accumulation by reducing lipogenesis‐associated gene expression. Furthermore, downregulation of IGFBP7 markedly ameliorated IR and restored impaired insulin signalling by elevating the phosphorylation levels of IRS‐1, Akt and GSK3β in HFD‐treated mice. Similar results were also confirmed by an in vitro study in a palmitic acid (PA)‐stimulated HepG2 cell model. In conclusion, our study demonstrates that IGFBP7 contributes to hepatic steatosis and insulin resistance in NAFLD development, which might serve as a novel therapeutic agent for the treatment of NAFLD.