bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐Area Hexagonal Boron Nitride for Surface Enhanced Raman Spectroscopy
Authors: Chugh Dipankar , Jagadish Chennupati , Tan Hoe 
Published: May 2019

AbstractApplication of atomically thin layers of hexagonal boron nitride (hBN) for passivating gold and silver nanoparticles is investigated and its potential use is demonstrated through surface‐enhanced Raman spectroscopy (SERS). Silver nanoparticles readily oxidize in air, resulting in a significant decrease in its SERS activity. hBN is a novel 2D material, well‐known for its thermal and chemical stability. In this study, wafer‐scale hBN is grown using metal organic vapor phase epitaxy (MOVPE) and centimeter‐sized hBN layers are transferred on to silver nanoparticles. hBN acts as an impermeable barrier and protects silver nanoparticles from oxidation, even at elevated temperatures and help retain its SERS activity. Thermal stability of hBN coated Ag nanoparticles is studied in detail. Furthermore, wafer‐scale hBN layers grown using MOVPE are especially attractive, compared to mechanically exfoliated, micrometer sized flakes from bulk crystals, as it can be easily scaled‐up, shown here through design and fabrication of a SERS chip, conducive for droplet‐based analysis. Overall, large‐area hBN layers are well suited for practical applications and can help improve the shelf‐life and reusability of commercially available SERS substrates.
Vertically Aligned Piezoelectric Perovskite Nanowire Array on Flexible Conducting Substrate for Energy Harvesting Applications
Authors: Hyeon Dong Yeol , Park Kwi‐Il 
Published: May 2019

AbstractEnergy conversion based on vertically aligned piezoelectric nanowire (NW) arrays is of great interest because of their unusual properties originating from large surface area/high aspect ratio and excellent piezoelectric properties. Here, perovskite‐structured piezoelectric BaTiO3 NW arrays are vertically grown onto the flexible Ti substrates by a two‐step hydrothermal reaction to realize an aligned 1D nanostructures‐based flexible energy harvester. The BaTiO3 NW array‐based flexible piezoelectric energy harvester (PEH) successfully converts a maximum open‐circuit voltage of ≈15 V, a maximum short‐circuit current of ≈400 nA, and an effective power of ≈0.27 µW during repeated bending deformations. Under pressing with an external force of 49.57 N, the harvested output signals of the vertically aligned NW arrays‐based PEH are ≈20 V and ≈60 nA. Finite element analysis with multiphysics simulation supports the hypothesis of effective potential generation by the NW arrays‐based flexible PEH. These results can aid in the further development of high‐output 1D nanostructures‐based flexible PEHs.
Nonvolatile Rewritable Photomemory Arrays Based on Reversible Phase‐Change Perovskite for Optical Information Storage
Authors: Zou Chen , Zheng Jiajiu , Chang Cheng , Majumdar Arka , Lin Lih Y. 
Published: May 2019

AbstractThe high transmission speed of optical signals and their application in optical computation have created a growing demand for photon‐programmed memory devices. Rather than using electrical pulses to store data in one of two states, the photomemory (PM) devices exploit the optical stimulation to store the light information. In this work, the application of a nonvolatile rewritable PM array using the photochromic inorganic perovskite CsPbIBr2 grown by a vapor‐deposition process is demonstrated. Reversible phase transitions between orthorhombic (δ) and cubic (α) phases are achieved in CsPbIBr2 films through laser‐induced heat and moisture exposure. The PM pixels in an optically absorbing perovskite phase exhibit ≈50‐fold photoresponsivity as large as those in a transparent‐colored non‐perovskite phase. Storing optical data are achieved by heating pixels through a near‐infrared laser, while moisture exposure is used to erase the stored information. The nonvolatile PM array exhibits great write‐read‐erase cycle endurance and data retention capability without obvious performance degradation after storage in air for one week. This work demonstrates the promising application of vapor‐deposited inorganic perovskite for optical information storage and the unique potential of them for use in optical switches, tunable metasurfaces, and many other applications.
Tuberous sclerosis in a patient from Nigeria
Authors: Ekure Ekanem N. , Addissie Yonit A. , Sokunbi Ogochukwu Jidechukwu , Kruszka Paul , Muenke Maximilian , Adeyemo Adebowale A. 
Published: May 2019

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant syndrome characterized by mostly benign tumors of the brain, skin, heart, kidney, and eye. Aberrations in the genes TSC1 and TSC2 which encode hamartin and tuberin, respectively, cause TSC. Because disease manifestations develop over time, early diagnosis and intervention are imperative for patients. TSC is not well described in patients from sub‐Saharan Africa or of black African ancestry. Here, we report on a 4‐year‐old Nigerian boy with skin lesions and cardiac anomalies associated with TSC. Furthermore, we note that in areas with limited resources for genetic diagnoses, the common skin manifestations found in TSC may be especially useful clinical markers.
Iron‐Catalyzed Ortho‐Selective C−H Alkylation of Aromatic Ketones with N‐Alkenylindoles and Partial Indolylation via 1,4‐Iron Migration
Authors: Kimura Naoki , Kochi Takuya , Kakiuchi Fumitoshi 
Published: May 2019

AbstractAn ortho‐selective C−H alkylation of aromatic ketones with N‐alkenylindoles proceeded in the presence of just a Fe(PMe3)4 catalyst. In addition, C−H indolylation products, which are considered to be formed via 1,4‐iron migration, were also observed as minor products.
Heteroaromatic Aldehydes with Unprecedented Catalytic Performance in Selective Radical Reactions: Synthesis of α‐Aminophosphonate Scaffolds
Authors: Aghahosseini Hamideh , Ramazani Ali , Taran Jafar , Ślepokura Katarzyna , Lis Tadeusz 
Published: May 2019

AbstractHeterocyclic compounds have gained immense importance because of their low resonance energy and strong hydrogen‐bonding abilities, which provide good catalytic potential in a variety of organic transformations. Herein an unexpected metal‐free catalytic performance of heteroaromatic aldehydes has been reported. Accordingly, a unique method for the synthesis of new scaffolds of peptidomimetic compounds, α‐aminophosphonates has been developed, which was difficult using previous methods. The aerobic auto‐oxidation of heteroaromatic aldehydes acts as a driving force for the coupling of aromatic N‐benzylamines and hydrophosphoryl compounds according to a one‐pot, metal‐ and solvent‐free procedure. Heteroaromatic aldehydes, in addition to their individual ability to promote selective radical reactions through the auto‐oxidation process, can provide hydrogen bonding frameworks at different stages of the reaction and thereby change the reaction pathways and induce new activities and selectivities, which unveiled their other important catalytic features. We believe that this highlights the catalytic potential of heteroaromatic aldehydes, which may offer an opportunity to change the traditional harsh conditions necessary to generate alkyl radicals.
Introducing Perylene as a New Member to the Azaborine Family
Authors: Kaehler Tanja , Bolte Michael , Lerner Hans‐Wolfram , Wagner Matthias 
Published: May 2019

AbstractSubstitutional doping of perylene with two boron atoms at the 6b/12b positions and two oxygen or nitrogen atoms at the 1/7 positions has been achieved. The modular synthesis route developed for these bis‐BO‐ (3) and bis‐BN‐perylenes (5) starts from the readily accessible borinic acid derivative of the doubly brominated 9,10‐dihydro‐9,10‐diboraanthracene (DBA), 1,5‐Br2DBA(OH)2. A Stille‐type reaction first furnishes the alkynyl‐substituted species 1,5‐(RCC)2DBA(OH)2 (2), which undergo double ring closure to afford 3 via the gold‐catalyzed addition of the O−H bonds to the C≡C bonds. Treatment of 2 with MeN(SiMe3)2 leads to aminoborane intermediates 1,5‐(RCC)2DBA(N(H)Me)2, which can be ring‐closed to give 5 in a similar manner as in the case of 3. Different substituents R (such as Me, tBuPh) can be introduced at the 2/8 positions of the perylene core. The products obtained undergo reversible reduction and are efficient blue/turquoise emitters.
Copper‐Catalyzed Regio‐ and Enantioselective Addition of Silicon Grignard Reagents to Alkenes Activated by Azaaryl Groups
Authors: Mao Wenbin , Xue Weichao , Irran Elisabeth , Oestreich Martin 
Published: May 2019

AbstractA new application of silicon Grignard reagents in C(sp3)−Si bond formation is reported. With the aid of BF3⋅OEt2, these silicon nucleophiles add across alkenes activated by various azaaryl groups under copper catalysis. An enantioselective version employing benzoxazole‐activated alkenes as substrates and a CuI‐josiphos complex as catalyst has been developed, forming the C(sp3)−Si bond with good to high enantiomeric ratios (up to 97:3). The method expands the toolbox for “conjugate addition” type C(sp3)−Si bond formation.
Improving the barrier character of poly(caprolactone): Transport properties and free volume of immiscible blends
Authors: Eceolaza Sorkunde , Sangroniz Ainara , del Río Javier , Iriarte Marian , Etxeberria Agustin 
Published: May 2019

ABSTRACTIn this work, the barrier character of poly(caprolactone) is improved with the addition of a poly(hydroxy amino ether). The analysis by means of thermal, thermomechanical, and morphology characterization reveals that the blends are partially miscible. The characterization of the morphology has revealed that the blends show a droplet matrix morphology. The free volume of the samples has been characterized by positron annihilation lifetime spectroscopy observing a decrease in the free volume as the poly(hydroxyamino ether) (PHAE) content increases. The barrier character to water vapor and carbon dioxide is greatly improved with the addition of PHAE. However, the observed improvement does not arise only from the reduced free volume, playing the interactions between penetrants and polymers a major role. Overall, this work aims to provide a further insight on the factors affecting the improvement of the barrier character of biodegradable polymers, which would allow developing new materials for packaging applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48018.
Effect of carbon nanotubes on the biodegradability of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) nanocomposites
Authors: da Silva Ana Paula , do Amaral Montanheiro Thaís Larissa , Stieven Montagna Larissa , Andrade Patrícia Fernanda , Durán Nelson , Lemes Ana Paula 
Published: May 2019

ABSTRACTIn this work, the effect of carbon nanotubes (CNT) on the biodegradability of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) nanocomposites with 1 and 2% (w/w) of CNT has been evaluated by biodegradation assays in aqueous medium containing microorganisms extracted from garden soil. After biodegradation process, samples of PHBV and PHBV/CNT were compared regarding magnitude of degradation by visual macroscopic analysis, by measurement of percentage of weight loss and by scanning electron microscopy (SEM). The samples were further characterized regarding roughness and hydrophilicity by contact angle measurement. The final residue resultant from biodegradation of PHBV/CNT was analyzed in a FEI Inspect F50 field emission scanning electron microscope (FESEM) in order to verify the presence of CNT. Our results indicated that CNT did not compromise the biodegradability of PHBV matrix although the biodegradation rate has decreased with the increase of CNT content as shown by the weight loss measurements. SEM analysis of PHBV/CNT nanocomposites after biodegradation process showed increased amount of CNT exposed at the matrix surface suggesting the possibility of CNT recovering after the biodegradation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48020.
A simple, rapid and fully validated HPLC method for simultaneous quantitative bio‐analysis of rosuvastatin and candesartan in rat plasma: Application to pharmacokinetic interaction study
Authors: Patel Misari , Kothari Charmy 
Published: May 2019

AbstractA simple, precise and accurate HPLC method was developed, optimized and validated for simultaneous determination of rosuvastatin and candesartan in rat plasma using atorvastatin as an internal standard. Solid‐phase extraction was used for sample cleanup and its subsequent optimization was carried out to achieve higher extraction efficiency and to eliminate matrix effect. A quality by design approach was used, wherein three‐level factorial design was applied for optimization of mobile phase composition and for assessing the effect of pH of the mobile phase using Design Expert Software. Adequate separation for both analytes was achieved with a Waters C18 column (250 × 4.6 mm, 5 μm) using acetonitrile–5 mm sodium acetate buffer (70:30, v/v; pH adjusted to 3.5 with acetic acid) as a mobile phase at a flow rate of 1.0 mL/min and wavelength of 254 nm. The calibration curves were linear over the concentration ranges 5–150 and 10–300 ng/mL for rosuvastatin (ROS) and candesartan (CAN), respectively. The validated method was successfully applied to a pharmacokinetic study in Wistar rats and the data did not reveal any evidence for a potential drug–drug interaction between ROS and CAN. This information provides evidence for clinical rational use of ROS and CAN.
Characterization of transcriptome profile and clinical features of a novel immunotherapy target CD204 in diffuse glioma
Authors: Yuan Yongliang , Zhao Qitai , Zhao Songfeng , Zhang Penghua , Zhao Haibiao , Li Zeyun , Du Yue , Tian Xin , Lu Jingli 
Published: May 2019

AbstractCD204 is a specific marker of tumor‐associated macrophages (TAMs) in glioma. However, the expression levels of CD204 and its involvement in glioma are not fully understood. In this large‐scale study, we assessed the expression and function of CD204 in whole‐grade glioma molecularly and clinically. In total, 1323 glioma samples, including 301 microarray data and 325 RNA‐seq data from the Chinese Glioma Genome Atlas (CGGA) dataset and 697 RNA‐seq data from The Cancer Genome Atlas (TCGA) dataset, were utilized. The statistical analysis and graphical work were mainly performed using the R software. Univariate and multivariate Cox analysis demonstrated that CD204 was an independent prognosticator in glioma patients. CD204 expression was positively correlated with the grade of malignancy. CD204 was consistently upregulated in wild‐type isocitrate dehydrogenase glioma and highly expressed in mesenchymal glioblastoma. Gene ontology of CD204‐related genes showed that CD204 was most enriched in inflammatory response and immune response. It was associated with the stromal and immune populations, especially the monocytic lineage, fibroblasts, and T cells. Circos plots revealed that CD204 was closely associated with many immune checkpoint regulators, especially TIM‐3. CD204 expression is consistent with the malignant phenotype of glioma and independently predicts poor outcomes in glioma patients. Additionally, CD204+ TAMs, collaborating with other checkpoint members, may contribute to the dysfunction of T cells. These findings suggest that CD204 may be a promising target for glioma immunotherapy.
Data‐driven retrieval of spray details with random forest‐based distance
Authors: Peng Chen , Zhao Zipeng , Li Chen , Wang Changbo , Qin Hong , Quan Hongyan 
Published: May 2019

AbstractGenerating realistic spray details in liquid simulations remains computationally expensive. This paper proposes a data‐driven method to simulate high‐resolution sprays on low‐resolution grids by retrieving details with the most compatible details from a precomputed repository efficiently. We first employ a random forest‐based distance (RFD) to measure the similarity of liquid regions. In consideration of spatiotemporal relationships between one liquid region and its neighbors, we define a multinary label for RFD instead of the original binary one. Our improved RFD enables us to retrieve details that fit ground truth the best. To ensure temporal continuity of our result and to generate new details from existing ones, we formulate a series of forests with a training set from different time steps. Then, we synthesize results of each forest according to their distances. Finally, we put the synthesis result in correct positions to generate desired sprays motion. In our method, a state‐of‐the‐art cascade forest is employed for a higher accuracy. Several experiments with various grid resolutions validate our method both in visual effect and computational cost.
Change in textural properties, starch digestibility, and aroma of nonfried instant noodles by substitution of konjac glucomannan
Authors: Park Eun Young , Kim Hyo Yeong , Shin Hye‐Young , Jeon Young‐Il , Kim Jae‐Min , Kim Semiga , Kim Jong‐Yea 
Published: May 2019

AbstractBackground and objectivesThe physicochemical properties, starch digestibility, and aroma profile of nonfried instant noodles with various glucomannan contents (0%, 0.5%, 1%, and 2%) were investigated to evaluate the effects of glucomannan on overall quality.FindingsThe substitution of glucomannan did not induce significant changes in the cooking properties (such as cooking loss and rehydration) and microstructure of the nonfried instant noodles relative to those of the control. The springiness, gumminess, tensile strength, and adhesiveness of the cooked noodles were not significantly changed by the substitution of glucomannan, while the hardness of cooked noodles decreased from 2,726 to 1,850 g as the level of glucomannan increased. For in vitro starch digestive properties, the resistant starch content of noodles increased from 1.61% to 4.57% as the level of glucomannan increased. Electronic nose analysis revealed that the substitution of glucomannan altered the aroma profile of nonfried instant noodle compared with that of the control and commercial konjac noodles.ConclusionsThe substitution of glucomannan influenced texture (especially, hardness), aroma, and starch digestibility of nonfried instant noodles.Significance and noveltyThe substitution of glucomannan in nonfried instant noodles can be effective approach to improve the textural properties and health‐promoting benefit of nonfried instant noodles.
Predictable Catalysis of Electron‐Rich Palladium Catalyst toward Aldehydes Hydrogenation
Authors: Wang Tao , Xu Yida , Yang Jie , Ju Xuehai , Ding Weiping , Zhu Yan 
Published: May 2019

AbstractThe catalytic properties of palladium can be purposely tailored through adjusting its electronic states by the interactions with supports. The palladium nanoparticles supported on N‐doped carbon matrix are characterized explicitly as electron‐enriched states via the charge transfer from the support to the metal. The electron‐enriched Pd catalyst shows enhanced activity for catalytic reduction of aldehydes with electron‐withdrawing groups, whereas it is detrimental to the hydrogenation of aldehydes with electron‐donating groups.
1,1′‐Binaphthyl Consisting of Two Donor–π–Acceptor Subunits: A General Skeleton for Temperature‐Dependent Dual Fluorescence
Authors: Liu Di‐Hong , Sun Zuo‐Bang , Zhao Zheng‐Hua , Peng Qian , Zhao Cui‐Hua 
Published: May 2019

AbstractTemperature‐dependent dual fluorescence with the anti‐Kasha's rule is of great interest, but is a very challenging property to achieve in small organic molecules. The highly sensitive temperature‐dependent dual fluorescence of 2,2′‐bis(dimethylamino)‐6,6′‐bis(dimesitylboryl)‐1,1′‐binaphthyl (BNMe2‐BNaph), which essentially consists of two donor–π–acceptor (D‐π‐A) subunits, inspired the exploration of the importance of its structural features and the general utility of this molecular design. The reference compound MBNMe2‐BNaph, which lacks one electron‐accepting Mes2B, is found to show less sensitive temperature‐dependent dual fluorescence, suggesting that the structure of BNMe2‐Bnaph, consisting of two symmetrical D‐π‐A subunits, is very important for achieving highly sensitive temperature‐dependent dual fluorescence. In addition, it is found that another two 1,1′‐binaphthyls, CHONMe2‐BNaph and CNNMe2‐BNaph, which also consist of two D‐π‐A subunits with Mes2B groups replaced by CHO and CN, respectively, also show temperature‐dependent dual fluorescence, with the fluorescence changing in a similar manner to BNMe2‐BNaph, indicating the general utility of the current molecular design for temperature‐dependent dual fluorescence. Furthermore, the temperature‐dependent dual fluorescence behaviors, such as the relative intensities of the two emission bands, the separation of the two emissions bands, and the sensitivity of the fluorescence intensity ratio to temperature, are greatly influence by the electron acceptors.
Retracted: A randomized controlled trial of mindfulness‐based stress reduction for insomnia secondary to cervical cancer: Effects on sleep
Authors: Zhang Huashuang , Li Yang , Li Mingming , Chen Xiaowen 
Published: May 2019

AbstractRetraction: ‘A randomized controlled trial of mindfulness‐based stress reduction for insomnia secondary to cervical cancer: Effects on sleep’ DOI https://doi.org/10.1002/cnr2.1190 by Huashuang Zhang, Yang Li, Mingming Li, Xiaowen Chen.The above article, published online on 29 May 2019 in Wiley Online Library (http://onlinelibrary.wiley.com), has been retracted by agreement between the authors, Huashuang Zhang, Yang Li, Mingming Li, Xiaowen Chen, the journal Editor in Chief Nidhi Bansal, and John Wiley and Sons Ltd. The retraction has been agreed because of an honest error discovered by the authors in the data presented in Table 4 that impacts the overall conclusions of the article.
Immunophenotypic Heterogeneity of Polytypic Plasma Cells and the Impact on Myeloma Minimal Residual Disease Detection by Multiparameter Flow Cytometry
Authors: Schouweiler Katie E. , Karandikar Nitin J. , Holman Carol J. 
Published: May 2019

BackgroundFlow cytometry is widely used for minimal residual disease (MRD) detection in plasma cell myeloma (PCM). Recently, an increasing number of studies have demonstrated that polytypic plasma cells (PPCs) display greater immunophenotypic variation than previously appreciated. Our aim was to further characterize the immunophenotype of PPC in this setting.MethodsPPC in 102 bone marrow specimens (93 MRD‐negative post‐treatment PCM and 9 negative initial evaluations for plasma cell neoplasm) were evaluated by 10‐color flow cytometry. Frequency of CD19, CD27, CD28, CD56, CD117, and CD138 expression was assessed.ResultsAll cases showed CD27 and CD19 positivity. CD117 was uniformly negative. Percentage of CD138 expression was variable with one negative case (<20% expression). Percentage of CD28 and CD56 expression was variable and included 11 CD28+ cases as well as 38 CD56+ cases. Forty‐two percent (43 of 102) cases showed atypical expression of at least one marker with 36 cases (35%) showing atypical expression of a single marker and 7 cases (7%) showing dual atypical marker expression (CD56+/CD28+).ConclusionsConsiderable immunophenotypic variation exists in PPC. The assessment of cytoplasmic light chain distribution, in conjunction with surface marker expression, is recommended to avoid diagnostic inaccuracy in MRD evaluation. © 2019 International Clinical Cytometry Society