bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum of Sellar and Parasellar Region Lesions: A retrospective study from Basrah, Iraq
Authors: Mansour Abbas Ali , Alhamza Ali Hussain Ali , Almomin Ammar Mohammed Saeed Abdullah , Zaboon Ibrahim Abbood , Alibrahim Nassar Taha Yaseen , Hussein Rudha Naser , Kadhim Muayad Baheer , Alidrisi Haider Ayad Yassin , Nwayyir Hussein Ali , Mohammed Adel Gassab , Al-Waeli Dheyaa Kadhim , Hussein Ibrahim Hani 
Published: April 2018

Background: Sellar and parasellar region lesions spectrum includes a wide variety of diseases. This study aimed at providing a comprehensive overview of such lesions in patients from Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah (Southern Iraq).Methods:Retrospective data analysis from FDEMC for the period January 2012 through June 2017. We included all patients with sellar and parasellar region lesions who received a MRI scan on their pituitary regionResults:The total enrolled patients were 232 (84 men and 148 women),with age range 15-75 years.Pituitary disease and adenoma were more common among women. Those with macroadenoma were older than those with microadenoma, with nearly equal gender prevalence of macroadenoma. Pituitary adenoma constituted the bulk of pituitary disease in this setting (67.2%). Growth hormone secreting adenoma were the most common adenoma seen in 41.0%, followed by clinically non-functioning pituitary adenoma (NFPA) in 31.4% and prolactinoma in 26.9%. About 64.8% of pituitary adenoma was macroadenoma. Macroadenoma was seen in 73.4% of growth hormone secreting adenoma (acromegaly), 61.2% in NFPA and 62.0% of prolactinom a(of them six were giant prolactinoma).Conclusion: Pituitary adenoma constituted the bulk of sellar and parasellar region lesions, growth hormone secreting adenoma is the the most common adenoma followed by NFPA and prolactinoma due to referral bias. A change in practice of adenoma treatment is needed.
The management of acute myocardial infarction in the Russian Federation: protocol for a study of patient pathways
Authors: Kontsevaya Anna , Bobrova Natalia , Barbarash Olga , Duplyakov Dmitry , Efanov Alexey , Galyavich Albert , Frants Maria , Khaisheva Larisa , Malorodova Tatyana , Mirolyubova Olga , Nedbaikin Andrei , Osipova Irina , Platonov Dmitry , Posnenkova OIga , Syromiatnikova Liudmila , Bates Katie , Leon David A , McKee Martin 
Published: April 2018

Background: Death rates from cardiovascular disease in Russia are among the highest in the world. In recent years, the Russian government has invested substantially in the healthcare system, with a particular focus on improving access to advanced technology, especially for acute myocardial infarction (AMI). This protocol describes a study to understand the management of AMI in different Russian regions, investigating the role of patient, clinical, and health system characteristics. Methods: A prospective observational study has recruited a representative sample of AMI patients within 16 hospitals from 13 regions across Russia. Criteria for inclusion are being aged 35-70 years with a confirmed diagnosis of AMI and surviving until the day after admission. Information being collected includes health system contacts and features of clinical management prior to the event and in the 12 months following discharge from hospital. Following initial exploration of the data to generate hypotheses, multivariate analyses will be applied to assess the role of these characteristics in both treatment decisions and any delays in time critical interventions. Between June 2015 and August 2016, 1,122 patients have been recruited at baseline and follow-up to 12 months post-discharge is scheduled to be completed by autumn 2017. The study is unique in examining patient factors, clinical management prior to admission and in hospital in the acute phase and throughout the critical first year of recovery across a diverse range of geographies and facilities. It uses standardized instruments to collect data from patients and health care providers and includes regions that are diverse in terms of geography and development of cardiology capacity. However, given the limited health services research capacity in the Russian Federation, it was not possible to obtain a sample that was truly nationally representative.
B cell, CD8+ T cell and gamma delta T cell infiltration alters alveolar immune cell homeostasis in HIV-infected Malawian adults
Authors: Mwale Andrew , Hummel Annemarie , Mvaya Leonard , Kamng'ona Raphael , Chimbayo Elizabeth , Phiri Joseph , Malamba Rose , Kankwatira Anstead , Mwandumba Henry C , Jambo Kondwani C 
Published: April 2018

Background: HIV infection is associated with increased risk to lower respiratory tract infections (LRTI). However, the impact of HIV infection on immune cell populations in the lung is not well defined. We sought to comprehensively characterise the impact of HIV infection on immune cell populations in the lung.Methods: Twenty HIV-uninfected controls and 17 HIV-1 infected ART-naïve adults were recruited from Queen Elizabeth Central Hospital, Malawi. Immunophenotyping of lymphocyte and myeloid cell populations was done on bronchoalveolar lavage fluid and peripheral blood cells.Results: We found that the numbers of CD8+T cells, B cells and gamma delta T cells were higher in BAL fluid of HIV-infected adults compared to HIV-uninfected controls (all p<0.05). In contrast, there was no difference in the numbers of alveolar CD4+T cells in HIV-infected adults compared to HIV-uninfected controls (p=0.7065). Intermediate monocytes were the predominant monocyte subset in BAL fluid (HIV-, 63%; HIV+ 81%), while the numbers of classical monocytes was lower in HIV-infected individuals compared to HIV-uninfected adults (1 × 105vs. 2.8 × 105cells/100ml of BAL fluid, p=0.0001). The proportions of alveolar macrophages and myeloid dendritic cells was lower in HIV-infected adults compared to HIV-uninfected controls (all p<0.05).Conclusions: Chronic HIV infection is associated with broad alteration of immune cell populations in the lung, but does not lead to massive depletion of alveolar CD4+T cells. Disruption of alveolar immune cell homeostasis likely explains in part the susceptibility for LRTIs in HIV-infected adults.
Safe Opioid Prescribing for Acute Noncancer Pain in Hospitalized Adults: A Systematic Review of Existing Guidelines
Authors: Herzig Shoshana J. , Calcaterra Susan L. , Mosher Hilary J. , Ronan Matthew V. , Van Groningen Nicole , Shek Lili , Loffredo Anthony , Keller Michelle , Jena Anupam B. , Nuckols Teryl K. 
Published: April 2018

BACKGROUNDPain is common among hospitalized patients. Inpatient prescribing of opioids is not without risk. Acute pain management guidelines could inform safe prescribing of opioids in the hospital and limit associated unintended consequences.PURPOSETo evaluate the quality and content of existing guidelines for acute, noncancer pain management.DATA SOURCESThe National Guideline Clearinghouse, MEDLINE via PubMed, websites of relevant specialty societies and other organizations, and selected international search engines.STUDY SELECTIONGuidelines published between January 2010 and August 2017 addressing acute, noncancer pain management among adults were considered. Guidelines that focused on chronic pain, specific diseases, and the nonhospital setting were excluded.DATA EXTRACTIONQuality was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument.DATA SYNTHESISFour guidelines met the selection criteria. Most recommendations were based on expert consensus. The guidelines recommended restricting opioids to severe pain or pain that has not responded to nonopioid therapy, using the lowest effective dose of short‐acting opioids for the shortest duration possible, and co‐prescribing opioids with nonopioid analgesics. The guidelines generally recommended checking the prescription drug monitoring program when prescribing opioids, developing goals for patient recovery, and educating patients regarding the risks and side effects of opioid therapy. Additional recommendations included using an opioid‐dose conversion guide, avoidance of co‐administration of parenteral and oral opioids, and using caution when co‐prescribing opioids with other central nervous system depressants.CONCLUSIONSGuidelines, based largely on expert opinion, recommend judicious prescribing of opioids for severe, acute pain. Future work should assess the implications of these recommendations on hospital‐based pain management.
Random Projection Estimation of Discrete-Choice Models with Large Choice Sets
Authors: Chiong Khai Xiang , Shum Matthew 
Published: April 2018

We introduce random projection, an important dimension-reduction tool from machine learning, for the estimation of aggregate discrete-choice models with high-dimensional choice sets. Initially, high-dimensional data are projected into a lower-dimensional Euclidean space using random projections. Subsequently, estimation proceeds using cyclical monotonicity moment inequalities implied by the multinomial choice model; the estimation procedure is semiparametric and does not require explicit distributional assumptions to be made regarding the random utility errors. Our procedure is justified via the Johnson–Lindenstrauss lemma—the pairwise distances between data points are preserved through random projections. The estimator works well in simulations and in an application to a supermarket scanner data set. This paper was accepted by Juanjuan Zhang, marketing.
Private Ownership and the Cost of Public Debt: Evidence from the Bond Market
Authors: Badertscher Brad A. , Givoly Dan , Katz Sharon P. , Lee Hanna 
Published: April 2018

A number of studies have examined the effect of public and private ownership on the cost of debt and concluded that the cost of debt of privately owned firms is higher, driven mainly by the poorer information environment in which these firms operate. We extend this strand of research in two ways. First, we identify and empirically establish the mechanisms that bring about a higher cost of debt to privately owned firms—namely, the limited access that these firms have to the equity capital market, their high rate of management and private-equity ownership, and their less conservative reporting. Second, we improve the reliability of the estimates of the effect of ownership type on the cost of debt by controlling for the different information environments in which privately and publicly owned firms operate. This is accomplished through the use of a sample consisting of publicly owned and privately owned firms that have public debt and are therefore subject to identical reporting and disclosure requirements. Certain data and design features allow us to better control for other factors that might lead to the observed difference in the cost of debt between the two groups of firms. The results contribute to our understanding of the role of ownership type on the cost of capital. This paper was accepted by Suraj Srinivasan, accounting.
Trade Relationships, Indirect Economic Links, and Mergers
Authors: Harford Jarrad , Schonlau Robert , Stanfield Jared 
Published: April 2018

The economic links between firms created by customer and supplier relationships are critical determinants of those firms’ values and actions. We demonstrate that significant trade relationships and indirect economic links incrementally explain which firms are more likely to be involved in acquisitions, which pairs of firms are more likely to merge, and which mergers will have the greatest impact, both on value and in motivating follow-on mergers by rivals. Firms with major trade relationships are significantly less likely to acquire, or be acquired by, firms that do not share in those relationships. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2938 . This paper was accepted by Lauren Cohen, finance.
Tail Risk Concerns Everywhere
Authors: Gao George P. , Lu Xiaomeng , Song Zhaogang 
Published: April 2018

We show that the beta with respect to an index of global ex ante tail risk concerns (𝔾ℝ𝕀𝕏), which we construct using out-of-the-money options on multiple global assets, negatively drives cross-sectional return variations across asset classes, including international equity indices, foreign currencies, and government bond futures. The pricing power of 𝔾ℝ𝕀𝕏 becomes stronger when more asset-class-level tail risk concerns are incorporated in the index construction. 𝔾ℝ𝕀𝕏 also dominates asset-class-level tail risk concerns in pricing assets within each asset class. These evidences imply that the pricing effect of tail risk concerns works predominantly as a global channel. The 𝔾ℝ𝕀𝕏 pricing effect is distinct from that of tail risk factors based on historical realizations, consistent with the interpretation that tail risk concerns likely reflect investors’ ex ante subjective belief about tail risk. This paper was accepted by Neng Wang, finance.
Optimization Approaches for the Traveling Salesman Problem with Drone
Authors: Agatz Niels , Bouman Paul , Schmidt Marie 
Published: April 2018

The fast and cost-efficient home delivery of goods ordered online is logistically challenging. Many companies are looking for new ways to cross the last mile to their customers. One technology-enabled opportunity that recently has received much attention is the use of drones to support deliveries. An innovative last-mile delivery concept in which a truck collaborates with a drone to make deliveries gives rise to a new variant of the traveling salesman problem (TSP) that we call the TSP with drone. In this paper, we model this problem as an integer program and develop several fast route-first, cluster-second heuristics based on local search and dynamic programming. We prove worst-case approximation ratios for the heuristics and test their performance by comparing the solutions to the optimal solutions for small instances. In addition, we apply our heuristics to several artificial instances with different characteristics and sizes. Our experiments show that substantial savings are possible with this concept compared to truck-only delivery. The online appendix is available at https://doi.org/10.1287/trsc.2017.0791 .
Short Communication New record of Indian oil sardine Sardinella longiceps from the coastal region of Bangladesh
Authors: SHAMSUNNAHAR SHAMSUNNAHAR , BAKI MOHAMMAD ABDUL , SARKER ANIRBAN , BEGUM MOST. HASINA , ZAFARIA A. B.M. , ISLAM NAFISA NAWAL , AHMED MD. SAGIR 
Published: April 2018

Shamsunnahar, Baki MA, Sarker A, Hasina Begum M, Zafaria M, Islam NN, Ahmed MdS. 2017. New record of Indian oil sardine Sardinella longiceps from the coastal region of Bangladesh. Ocean Life 1: 11-13. We report the first record of Indian oil sardine Sardinella longiceps from the southern coast of the Bay of Bengal, Bangladesh. The sample specimens were collected from Pathorghata, Barguna, Bangladesh on 25th October, 2015. Morphometric and meristic studies were performed for taxonomic identification. Genomic DNA was extracted from tissue samples and mitochondrial Cytochrome Oxidase Subunit I (COI) gene was amplified for molecular characterization of this species. The morphometric and meristic data and DNA barcoding confirm the presence of S. longiceps in Bangladesh. This report updates the geographical distribution for this species confirming its presence in the coastal region of Bangladesh, and extends the number of marine fish known from the area.
Computation of energy efficient driving speeds in conveying systems
Authors: Windmann Stefan , Niggemann Oliver , Stichweh Heiko 
Published: April 2018

Abstract
This article addresses the automatic optimization of driving speeds in conveying systems. Electric drives in existing conveying systems are usually accelerated and decelerated according to predetermined movement profiles. Such an approach is inflexible for conveying applications with changing constraints and, in many cases, not optimal with respect to energy efficiency. In the present work, a method for automatic computation of energy efficient movement profiles is proposed. The proposed method is based on accurate models for electric drives and several types of conveying applications such as roll conveyors, belt conveyors and vertical conveyors. Furthermore, joint energy efficiency optimization for two drives, which are attached to an intermediate circuit, is investigated. Thereby, additional constraints on the energy flow between the drives are imposed in order to reduce load peaks and energy feedback into the grid. The resulting optimization problem is a mixed integer quadratic program (MIQP), which can be solved in a few milliseconds. Experimental results show that energy losses of electric drives are cut down by using the obtained non-trivial movement profiles instead of standard trapezoid movement profiles. The additional constraints on the energy flow between two drives lead to further significant improvements with respect to the overall energy losses.
Online parameter estimation for cyber-physical production systems based on mixed integer nonlinear programming, process mining and black-box optimization techniques
Authors: Otto Jens , Vogel-Heuser Birgit , Niggemann Oliver 
Published: April 2018

Abstract
Cyber-Physical Production Systems (CPPS) should adapt to new products or product variants efficiently and without extensive manual engineering effort. In comparison to rewriting the automation software for each adaption, manual engineering effort can be reduced by reusable software components with free parameters, which must be adjusted to individual production scenarios. This paper introduces CyberOpt Online, a novel online parameter estimation approach for reusable automation software components. In contrast to classic mathematical modeling approaches, such as Mixed Integer Nonlinear Programming (MINLP), our approach requires no predefined models that represent the system. Models, e. g., of the energy consumption of CPPS, are learned automatically from data observed during the operation of the production system. Therefore, the manual engineering effort is minimized as postulated by the paradigm of CPPS. The presented approach combines MINLP, process mining and black-box optimization techniques for calculating optimal timing parameter configurations for automation software components with free parameters in the domain of discrete manufacturing.
Parametrization of extremals for some generalization of Chebotarev's problem
Authors: Tamrazov Promarz 
Published: April 2018

Abstract
We establish the parametrization of extremals for the problem which is one of the known generalizations of Chebotarev's problem.
The parametrization of this problem essentially differs from that of Chebotarev's problem and Grötzsch's problem, which is a generalization of Chebotarev's problem.
Added Mass of Fluid and Fundamental Frequencies of a Horizontal Elastic Circular Plate Vibrating in Fluid of Constant Depth
Authors: Szmidt Kazimierz , Hedzielski Benedykt 
Published: April 2018

Abstract
The paper deals with free vibrations of a horizontal thin elastic circular plate submerged in an infinite layer of fluid of constant depth. The motion of the plate is accompanied by the fluid motion, and thus, the pressure load on this plate results from displacements of the plate in time. The plate and fluid motions depend on boundary conditions, and, in particular, the pressure load depends on the gap between the plate and the fluid bottom. In theoretical description of this phenomenon, we deal with a coupled problem of hydrodynamics in which the plate and fluid motions are coupled through boundary conditions at the plate surfaces. This coupling leads to the so-called co-vibrating (added) mass of fluid, which significantly changes the fundamental frequencies (eigenfrequencies) of the plate. In formulation of the problem, a linear theory of small deflections of the plate is employed. At the same time, one assumes the potential fluid motion with the potential function satisfying Laplace’s equation within the fluid domain and appropriate boundary conditions at fluid boundaries. In order to solve the problem, the infinite fluid domain is divided into sub-domains of simple geometry, and the solution of problem equations is constructed separately for each of these domains. Numerical experiments have been conducted to illustrate the formulation developed in this paper.
Influence of hygrothermal condition on dynamic viscoelasticity of Chinese fir (Cunninghamia lanceolata). Part 2: moisture desorption
Authors: Zhan Tianyi , Jiang Jiali , Lu Jianxiong , Zhang Yaoli , Chang Jianmin 
Published: April 2018

Abstract
The influence of hygrothermal condition on dynamic viscoelasticity of Chinese fir (Cunninghamia lanceolata) during the moisture desorption (MDes) process was investigated. The ambient hygrothermal environments were set up as a series of constant temperatures and two relative humidity (RH) modes (RHramp-down and RHisohume). The MDes provided space for the rearrangement of the hydrogen bonds (Re-HB) and caused a mechano-sorptive (MS) effect. The enhancement of the Re-HB effect negatively correlated with the increment of loss modulus, while the elevation of the MS and the heating effects intensified the loss modulus. Lower values of RHc, determining the plateau area of loss modulus, were obtained at higher temperatures or greater RH ramping rates. The residual instability in the wood cell wall was quantitatively characterized by the extent of the MS effect. Residual instability was inversely proportional to the RHisohume level during the MDes process. The study of time dependent viscoelastic properties under moisture changing process provided insight into the condition of adsorbed water in the cell wall and optimized the manufacturing technique involved in the thermo-hygro-mechanical treatment of wood.
Targeting autophagy for the treatment of cancer
Authors: Fulda Simone 
Published: April 2018

Abstract
Macroautophagy (herein termed autophagy) is evolutionarily highly conserved across eukaryotic cells and represents an intracellular catabolic process that targets damaged macromolecules and organelles for degradation. Autophagy is dysregulated in various human diseases including cancer. In addition, many drugs currently used for the treatment of cancer can engage autophagy, which typically promotes cancer cell survival by mitigating cellular stress. However, under certain circumstances activation of autophagy upon anticancer drug treatment can also trigger a lethal type of autophagy termed autophagic cell death (ACD). This may pave new avenues for exploiting the autophagic circuitry in oncology. This review presents the concept and some examples of anticancer drug-induced ACD.
Paul McGhee and humor research
Authors: Goldstein Jeffrey , Ruch Willibald 
Published: April 2018

AbstractHumor research has developed along a trajectory, and branched out in many directions, that were foreseen and stimulated by Paul McGhee. From his initial interest in children’s humor and cognitive development as a graduate student at Ohio State University to his work applying humor in myriad settings, McGhee has broadened our understanding of humor and expanded its horizons. As early as the 1970s, Paul expressed interest in the neuropsychology of humor and laughter and in the evolution of humor in nonhuman primates. The development and validation of the Sense of Humor Scale is an integral part of the 7 Humor Habits Program used effectively to train humor skills. McGhee played an early role in advocating humor and laughter as a learnable tool in the promotion of health and well-being, and in the training of health-care personnel. His work has been recognized through various Lifetime Achievements awards and other honors.