bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generic Isolated Cell Image Generator
Authors: Scalbert Marin , Couzinie‐Devy Florent , Fezzani Riadh 
Published: October 2019

AbstractBuilding automated cancer screening systems based on image analysis is currently a hot topic in computer vision and medical imaging community. One of the biggest challenges of such systems, especially those using state‐of‐the‐art deep learning techniques, is that they usually require a large amount of training data to be accurate. However, in the medical field, the confidentiality of the data and the need for medical expertise to label them significantly reduce the amount of training data available. A common practice to overcome this problem is to apply data set augmentation techniques to artificially increase the size of the training data set. Classical data set augmentation methods such as geometrical or color transformations are efficient but still produce a limited amount of new data. Hence, there has been interest in data set augmentation methods using generative models able to synthesize a wider variety of new data. VitaDX is actually developing an automated bladder cancer screening system based on the analysis of cell images contained in urinary cytology digital slides. Currently, the number of available labeled cell images is limited and therefore exploitation of the full potential of deep learning techniques is not possible. In an attempt to increase the number of labeled cell images, a new generic generator for 2D cell images has been developed and is described in this article. This framework combines previous works on cell image generation and a recent style transfer method referred to as doodle‐style transfer in this article. To the best of our knowledge, we are the first to use a doodle‐style transfer method for synthetic cell image generation. This framework is quite modular and could be applied to other cell image generation problems. A statistical evaluation has shown that features of real and synthetic cell images followed roughly the same distribution. Finally, the realism of the synthetic cell images has been assessed through a visual evaluation performed with the help of medical experts. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Parental deployment and distress, and adolescent disordered eating in prevention‐seeking military dependents
Authors: Higgins Neyland M. K. , Shank Lisa M. , Burke Natasha L. , Schvey Natasha A. , Pine Abigail , Quattlebaum Mary , Leu William , Gillmore Dakota , Morettini Alexandria , Wilfley Denise E. , Stephens Mark , Sbrocco Tracy , Yanovski Jack A. , Jorgensen Sarah , Klein David A. , Olsen Cara H. , Quinlan Jeffrey , Tanofsky‐Kraff Marian 
Published: October 2019

AbstractObjectiveParental military deployment can lead to stress in the family system due to concerns about the deployed service‐member's safety and increased responsibilities for those not deployed. Parent‐related stress can impact adolescent disordered eating. Given the important role that stress plays in disordered eating and obesity, it is crucial to understand the impacts of unique stressors to which vulnerable populations are exposed.MethodWe studied 126 adolescent (14.3 ± 1.6 years; 59.5% girls; 44.4% non‐Hispanic White; BMI‐z, 1.91 ± .39) military dependents prior to entering an obesity and binge‐eating disorder prevention trial. The Eating Disorder Examination was used to assess adolescent disordered eating. Parents self‐reported their own distress and family deployment history that occurred during the adolescent's lifetime.ResultsParental distress interacted with frequency of parental deployments such that for those with high parental distress, more frequent deployment was associated with greater adolescent shape and weight concerns (β = .21, p = .012) and global eating pathology (β = .18, p = .024).DiscussionIn this hypothesis‐generating study, the combination of number of deployments and parental distress may be associated with disordered eating among adolescent military dependents seeking prevention of binge‐eating disorder and adult obesity. If these preliminary findings are supported longitudinally, interventions to reduce parental stress related to deployment may be warranted to reduce disordered eating in adolescent dependents.
Beneficial effects of ivabradine in patients with heart failure, low ejection fraction, and heart rate above 77 b.p.m.
Authors: Bouabdallaoui Nadia , O'Meara Eileen , Bernier Virginie , Komajda Michel , Swedberg Karl , Tavazzi Luigi , Borer Jeffrey S. , Bohm Michael , Ford Ian , Tardif Jean‐Claude 
Published: October 2019

AbstractAimsIvabradine has been approved in heart failure with reduced ejection fraction (HFrEF) and elevated heart rate despite guideline‐directed medical therapy (GDMT) to reduce cardiovascular (CV) death and hospitalization for worsening HF. The median value of 77 b.p.m. is the lower bound selected for the regulatory approval in Canada, South Africa, and Australia. Patient‐reported outcomes (PROs) including symptoms, quality of life, and global assessment are considered of major interest in the global plan of care of patients with HF. However, the specific impact of GDMT, and specifically ivabradine, on PRO remains poorly studied. In the subgroup of patients from the Systolic Heart failure treatment with the If inhibitor ivabradine Trial (SHIFT) who had heart rate above the median of 77 b.p.m. (pre‐specified analysis) and for whom the potential for improvement was expected to be larger, we aimed (i) to evaluate the effects of ivabradine on PRO (symptoms, quality of life, and global assessment); (ii) to consolidate the effects of ivabradine on the primary composite endpoint of CV death and hospitalization for HF; and (iii) to reassess the effects of ivabradine on left ventricular (LV) remodelling.Methods and resultsComparisons were made according to therapy, and proportional hazards models (adjusted for baseline beta‐blocker therapy) were used to estimate the association between ivabradine and various outcomes. In SHIFT, n = 3357 (51.6%) patients had a baseline heart rate > 77 b.p.m. After a median follow‐up of 22.9 months (inter‐quartile range 18–28 months), ivabradine on top of GDMT improved symptoms (28% vs. 23% improvement in New York Heart Association functional class, P = 0.0003), quality of life (5.3 vs. 2.2 improvement in Kansas City Cardiomyopathy Questionnaire overall summary score, P = 0.005), and global assessment [from both patient (improved in 72.3%) and physician (improved in 61.0%) perspectives] significantly more than did placebo (both P < 0.0001). Ivabradine induced a 25% reduction in the combined endpoint of CV death and hospitalization for HF (hazard ratio 0.75; P < 0.0001), which translates into a number of patients needed to be treated for 1 year of 17. Patients under ivabradine treatment demonstrated a significant reduction in LV dimensions when reassessed at 8 months (P < 0.05).ConclusionsIn patients with chronic HFrEF, sinus rhythm, and a heart rate > 77 b.p.m. while on GDMT, the present analysis brings novel insights into the role of ivabradine in improving the management of HFrEF, particularly with regard to PRO (ISRCTN70429960).
Piper betleoides C. DC.: Edible source of betel‐scented sesquiterpene‐rich essential oil
Authors: Kemprai Phirose , Bora Pranjit Kumar , Mahanta Bhaskar Protim , Sut Dristi , Saikia Siddhartha Proteem , Banik Dipanwita , Haldar Saikat 
Published: October 2019

AbstractBetel leaf or ‘Paan’ (Piper betle) is an integral component of the addictive chewing stimulant ‘betel quid’ which is traditionally consumed by a large population in the Asian countries. Betel essential oil is also heavily used by the flavour industries. Often, it constitutes of carcinogenic and genotoxic phenylpropanoids. High incidence of the oral carcinogenesis in this part of the world has been linked to the chewing of betel quid as well as Paan. In this study, Piper betleoides C. DC. (wild Paan) was identified as the edible plant source from north‐east India possessing betel‐scented essential oil which was highly rich in sesquiterpenoids majorly germacrene D and β‐caryophyllene. Identity of the plant was confirmed through critical taxonomic studies. Further, the essential oil yield and composition were investigated across different vegetative (young and mature leaves, stem) and reproductive (male and female inflorescence) tissues of P. betleoides through gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance (1H, 13C NMR) spectroscopic analyses. The comparative quantitative investigation showed a high dominance by sesquiterpenoids (>90%) in the leaves of P. betleoides with no detection of phenylpropanoids. On the contrary, a high level of phenylpropanoids (>75%) was found in P. betle (Bangla Paan). In effect, P. betleoides can be a potential alternative source of betel‐scented sesquiterpene‐rich essential oil.
Intraoperative and postanesthesia care unit fluid administration as risk factors for postoperative complications in patients with head and neck cancer undergoing free tissue transfer
Authors: Dooley Bryan J. , Karassawa Zanoni Daniella , Mcgill Marlena R. , Awad Mahmoud I. , Shah Jatin P. , Wong Richard J. , Broad Clara , Mehrara Babak J. , Ganly Ian , Patel Snehal G. 
Published: October 2019

AbstractBackgroundThis study aims to evaluate the impact of perioperative fluid administration, defined as fluid delivered intraoperatively and in the postanesthesia care unit, on postoperative outcomes.MethodsMedical records of 102 patients with oral cavity squamous cell carcinoma undergoing free flap reconstruction between January 2011 and December 2015 were reviewed. The primary endpoint was development of a postoperative complication according to the Clavien‐Dindo classification. Perioperative factors recorded were Washington University Head and Neck Comorbidity Index, operating time, vasopressor use, blood loss, intraoperative fluid, and perioperative fluid.ResultsGreater perioperative fluid administration was independently associated with surgical complications, flap complications, overall incidence of any complication, and increased length of stay. Greater intraoperative fluid administration was independently associated with higher rates of surgical complications. Intraoperative delivery of vasopressors was not associated with flap or surgical complications.ConclusionReceiving less perioperative fluid was associated with fewer complications and decreased length of stay.
Effect of SWCNTs and MWCNTs Maxwell MHD nanofluid flow between two stretchable rotating disks under convective boundary conditions
Authors: Sreedevi P. , Reddy P. Sudarsana 
Published: October 2019

AbstractThe aim of the current analysis is to investigate heat and mass transfer characteristics of single and multi‐walled water‐based carbon nanotubes Maxwell nanofluid flow between continuously rotating stretchable disks under the sway of chemical reaction and radiation. Boundary conditions of the convective type of temperature are employed at both lower and upper rotating disks in the preparation. Similarity variables are employed to transform the governing partial differential equations into the nonlinear ordinary differential equations. The computational finite element method is applied to solve this nonlinear system of equations along with boundary conditions. The sway of different admissible parameters on the profiles of concentration, temperature, and velocity are inspected and revealed through graphs. Furthermore, the numerical solutions for rates of temperature, concentration, and rates of velocity are depicted in tabular form. It is revealed that temperature sketches deteriorate with augmented values of Deborah number at both upper and lower disks of single‐walled carbon nanotubes and multi‐walled carbon nanotubes with water‐based Maxwell nanofluids.
Enhanced recovery after surgery versus traditional care in total pelvic floor reconstruction surgery with transvaginal mesh
Authors: Gong Runqi , Hu Qing , Liu Dan , Zu Jianyu , Wu Ying , Xia Zhijun 
Published: October 2019

AbstractObjectiveTo investigate the impact of enhanced recovery after surgery (ERAS) on perioperative outcomes after total pelvic floor reconstruction surgery with transvaginal mesh.MethodsA single‐center, retrospective observational cohort study involved 177 patients who underwent total pelvic floor reconstruction surgery with transvaginal mesh between August 2015 and November 2017. Eighty‐five patients treated according to a traditional protocol formed the control group and 92 patients treated using the ERAS pathway were assigned to the ERAS group. Registered outcomes included demographic characteristics, intraoperative and postoperative data (first assisted walking time, first intestinal exhaust time, length of stay, hospital costs), and complications.ResultsThe first assisted walking time (40.6 ± 1.48 vs 23.56 ± 3.26 hours, P<0.001) and the first intestinal exhaust time (27.65 ± 11.63 vs 18.65 ± 10.68 hours, P<0.001) were earlier in the ERAS group. The implementation of the ERAS pathway was associated with shorter length of stay (121.35 vs 70.25 hours, P<0.001) and lower hospital costs (46 838.65 ± 2584.08 vs 42 793.57 ± 2560.3 RMB, P<0.001). There was no difference in surgical outcomes or postoperative complications between the two groups.ConclusionERAS is safe, economical, and reliable after total pelvic floor reconstruction surgery and promotes perioperative recovery without increasing complication rates.
In vivo anti‐inflammatory efficacy of the combined Bowman‐Birk trypsin inhibitor and genistein isoflavone, two biological compounds from soybean
Authors: Sadeghalvad Mona , Mohammadi‐Motlagh Hamid‐Reza , Karaji Ali Gorgin , Mostafaie Ali 
Published: October 2019

AbstractSoybean Bowman‐Birk protease inhibitor (BBI) and genistein, two biological compounds from soybean, are well‐known for their anti‐inflammatory, antioxidant, and anticancer activities. The aim of this study was designing a BBI‐genistein conjugate and then investigating its protective effect on lipopolysaccharide (LPS)‐induced inflammation in BALB/c mice, compared with the effects of combination of BBI and genistein. BBI was purified from soybean and the BBI‐genistein conjugate was synthesized. The BALB/c mice were intraperitoneally treated 2 hours before LPS induction. Our results showed that treatment with the combination of BBI and genistein greatly led to more reduced serum levels of tumor necrosis factor (TNF)‐α and interferon (IFN)‐γ compared with the treatments of BBI alone, the BBI‐genistein conjugate, and genistein alone, respectively. Moreover, the expression of TNF‐α and IFN‐γ in the splenocytes was significantly downregulated along with improving host survival against the LPS‐induced lethal endotoxemia in the same way. Our data support a new combined therapy using BBI and genistein, as natural anti‐inflammatory agents, to develop a new drug for inflammatory diseases.
Emotion regulation in adults with Klinefelter syndrome (47,XXY): Neurocognitive underpinnings and associations with mental health problems
Authors: van Rijn Sophie , Swaab Hanna 
Published: October 2019

AbstractObjectivesThe aim of this study is to evaluate if language and executive functioning deficits in individuals with the 47,XXY chromosomal pattern contribute to emotion regulation problems and related symptoms of psychopathology.MethodsA group of 26 adult men with 47,XXY completed measures of cognitive emotion regulation strategies, neurocognitive functioning, and symptoms of psychopathology.ResultsAtypical emotion regulation strategies were found in the XXY group, with increased expression of emotions (69%), avoiding (65%), distraction seeking (54%), and passive coping (54%). More difficulties in mental flexibility and attention regulation, and speeded responding were associated with more pronounced emotion expression (emotional outbursts). Emotion regulation problems were associated with symptoms of anxiety, depression, thought problems, and hostility.ConclusionThis study has identified emotion regulation as a potential target for treatment and intervention, with a specific focus on executive functions in the management of emotions in individuals with 47,XXY.
Effect of shading and grafting on yield and quality of tomato
Authors: Milenković Lidija , Mastilović Jasna , Kevrešan Žarko , Bajić Aleksandra , Gledić Aleksandra , Stanojević Ljiljana , Cvetković Dragan , Šunić Lj , Ilić Zoran S 
Published: October 2019

AbstractBACKGROUNDThe need to increase marketable tomato yields and decrease losses due to sunburn and disease during the summer motivates farmers to adopt additional cultural practices such as shading and grafting. To investigate complex interactions among grafting, shading, and tomato cultivar, grafted and ungrafted tomatoes (cv. 'Optima' F1 and cv. 'Big Beef' F1) were grown in the soil under net‐house cover, using pearl and red nets, and in unshaded conditions (open fields). Tomato fruit at the red stage of maturity were used for the analysis of quality traits, and total and marketable yields were recorded during the whole production season.RESULTSGrafting and shading in tomato production might be considered as cultivation practices to increase the marketable tomato yield. A decrease in sugar content increased the uptake of some micro elements (Fe and Zn) and macro elements (Ca). In some cases, firmer and less elastic skin may be expected due to grafting. Shading with pearl net might result in fruit with lower firmness and higher total, and particularly malic, acid content.CONCLUSIONShading with colored nets and grafting provide alternative strategies for achieving higher fruit yields and avoiding or reducing a decrease in tomato quality caused by environmental stresses such as excessive radiation and temperature in the summer cropping season. © 2019 Society of Chemical Industry
Pro‐vitamin A carotenoid content of 48 plantain (Musa AAB genome) cultivars sourced from eastern Democratic Republic of Congo
Authors: Blomme Guy , Ocimati Walter , Nabuuma Deborah , Sivirihauma Charles , Davey Mark , Buah Stephen , Van den Bergh Inge , Vutseme Lusenge , Bahati Liliane , Ekesa Beatrice 
Published: October 2019

AbstractBACKGROUNDVitamin A deficiency (VAD) is widespread in sub‐Saharan Africa (SSA). Unlike in developed countries, where the main source of vitamin A comes from meat, the diet of poor populations in SSA is largely plant based. It is thus important to identify local / popular plants with higher vitamin A content for combating VAD. Banana (including plantains) is an important staple food crop in this region. The identification and promotion of vitamin A‐rich banana cultivars could contribute significantly to the alleviation of VAD in areas heavily dependent on the crop. We assessed pro‐vitamin A carotenoid (pVACs) content in the fruit pulp of 48 local plantains from eastern Democratic Republic of Congo, to identify cultivars that could help reduce VAD, especially among young children and women of reproductive age.RESULTSMean pVACs content varied from 175–1756 μg/100 gfw in ripe fruits. Significant increases (P < 0.001) in total pVACs content occurred after ripening in all cultivars except ‘UCG II’. Retinol activity equivalents (RAE) in ripe fruits ranged from 12–113 μg/100 gfw. Fifteen plantain cultivars, including ‘Adili II’, ‘Nzirabahima’, ‘Mayayi’, ‘Buembe’, and ‘Sanza Tatu’ (associated with RAE values of 44 μg/100 gfw and above) can be considered as good sources of pVACs. Modest consumption (250 or 500 gfw) of the fruit pulp of the five best plantain cultivars at ripening stage 5 meets between 39–71% and 44–81% of vitamin A dietary reference intake (DRI) respectively, for children below 5 years old and women of reproductive age.CONCLUSIONThe 15 best plantain cultivars (especially the top 5) could potentially be introduced / promoted as alternative sources of pro‐vitamin A in banana‐dependent communities, and help to reduce cases of VAD substantially. © 2019 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix
Authors: Fields Adam C. , Lu Pamela , Enzinger Andrea , Goldberg Joel , Irani Jennifer , Bleday Ronald , Nash Garrett , Melnitchouk Nelya 
Published: October 2019

AbstractBackgroundGoblet cell carcinoid (GCC) tumors of the appendix are a rare malignancy. We aim to examine the overall survival per stage and the relationship between different treatment modalities and outcomes for patients with GCC tumors of the appendix.MethodsWe identified patients with GCC tumors of the appendix from the National Cancer Database. The main outcome was overall patient survival and cox proportional hazard models were used to ascertain predictors of survival.ResultsThere were 2552 patients identified. The median age of diagnosis was 57 (interquartile range: 49‐65) and 52.3% of patients were female. The 5‐year survival for Stage I disease was 91.1% (95% confidence interval [CI]: 82.2%‐95.7%), for Stage II disease was 90.5% (95% CI: 85.8%‐93.7%), for Stage III disease was 57.0% (95% CI: 45.0%‐67.3%), and for Stage IV disease was 18.9% (95% CI: 9.3%‐31.0%). In a Cox proportional hazard model, older age (hazard ratio [HR]: 1.1; 95% CI: 1.03‐1.12; P < .001), lymph node metastasis (HR: 6.9; 95% CI: 2.76‐17.01; P < .001), and positive surgical margins (HR: 2.9; 95% CI:1.13‐7.26; P = .003) were associated with worse overall survival for Stages I to III disease while only older age (HR: 1.03; 95% CI: 1.002‐1.06; P = .04) was associated with worse overall survival for Stage IV disease.ConclusionsPatients with GCC tumors of the appendix who have the nonmetastatic disease have a high 5‐year survival. We have identified several prognostic factors for GCC.
An assessment of transparency and reproducibility‐related research practices in otolaryngology
Authors: Johnson Austin L. , Torgerson Trevor , Skinner Mason , Hamilton Tom , Tritz Daniel , Vassar Matt 
Published: October 2019

Objectives/HypothesisClinical research serves as the foundation for evidence‐based patient care, and reproducibility of results is consequently critical. We sought to assess the transparency and reproducibility of research studies in otolaryngology by evaluating a random sample of publications in otolaryngology journals between 2014 and 2018.Study DesignReview of published literature for reproducible and transparent research practices.MethodsWe used the National Library of Medicine catalog to identify otolaryngology journals that met the inclusion criteria (available in the English language and indexed in MEDLINE). From these journals, we extracted a random sample of 300 publications using a PubMed search for records published between January 1, 2014 and December 31, 2018. Specific indicators of reproducible and transparent research practices were evaluated in a blinded, independent, and duplicate manner using a pilot‐tested Google form.ResultsOur initial search returned 26,498 records, from which 300 were randomly selected for analysis. Of these 300 records, 286 met inclusion criteria and 14 did not. Among the empirical studies, 2% (95% confidence interval [CI]: 0.4%‐3.5%) of publications indicated that raw data were available, 0.6% (95% CI: 0.3%‐1.6%) reported an analysis script, 5.3% (95% CI: 2.7%‐7.8%) were linked to an accessible research protocol, and 3.9% (95% CI: 1.7%‐6.1%) were preregistered. None of the publications had a clear statement claiming to replicate, or to be a replication of, another study.ConclusionsInadequate reproducibility practices exist in otolaryngology. Nearly all studies in our analysis lacked a data or material availability statement, did not link to an accessible protocol, and were not preregistered. Taking steps to improve reproducibility would likely improve patient care.Level of EvidenceNA Laryngoscope, 130: 1894–1901, 2020