bluuebunny/crossref_metadata_2025_split huggingface dataset:
VGluT1 Deficiency Impairs Visual Attention and Reduces the Dynamic Range of Short-Term Plasticity at Corticothalamic Synapses
Authors: Lindström Sarah H , Sundberg Sofie C , Larsson Max , Andersson Fredrik K , Broman Jonas , Granseth Björn 
Published: August 2019

Abstract
The most common excitatory neurotransmitter in the central nervous system, glutamate, is loaded into synaptic vesicles by vesicular glutamate transporters (VGluTs). The primary isoforms, VGluT1 and 2, are expressed in complementary patterns throughout the brain and correlate with short-term synaptic plasticity. VGluT1 deficiency is observed in certain neurological disorders, and hemizygous (VGluT1+/−) mice display increased anxiety and depression, altered sensorimotor gating, and impairments in learning and memory. The synaptic mechanisms underlying these behavioral deficits are unknown. Here, we show that VGluT1+/− mice had decreased visual processing speeds during a sustained visual-spatial attention task. Furthermore, in vitro recordings of corticothalamic (CT) synapses revealed dramatic reductions in short-term facilitation, increased initial release probability, and earlier synaptic depression in VGluT1+/− mice. Our electron microscopy results show that VGluT1 concentration is reduced at CT synapses of hemizygous mice, but other features (such as vesicle number and active zone size) are unchanged. We conclude that VGluT1-haploinsuficiency decreases the dynamic range of gain modulation provided by CT feedback to the thalamus, and this deficiency contributes to the observed attentional processing deficit. We further hypothesize that VGluT1 concentration regulates release probability by applying a “brake” to an unidentified presynaptic protein that typically acts as a positive regulator of release.
Infectious Complications of Addiction: A Call for a New Subspecialty Within Infectious Diseases
Authors: Serota David P , Barocas Joshua A , Springer Sandra A 
Published: August 2019

Abstract
Infectious diseases (ID) physicians are increasingly responsible for the management of infectious consequences of substance use disorders (SUD). While we are often consulted for diagnosis and treatment of the infectious disease, it is clear that successful management of these infections requires a holistic approach, including acknowledgement and treatment of the underlying SUD. As we have learned through years of treating human immunodeficiency virus and hepatitis C virus infections, ID physicians have unique expertise in addressing both the infection and the complex biopsychosocial factors that underpin the infection. Many ID physicians have incorporated the management of addiction as part of their scope of practice, and here we seek to give a name and define the role of these ID/addiction dual specialists. We define the potential role of ID/addiction physicians in clinical care, health administration, and research, as well as provide recommendations to bolster the supply and reach of this burgeoning subspecialty.
Growth, external markets and stock–flow norms: a Luxemburg–Godley model of accumulation
Authors: Thompson Stephen 
Published: August 2019

AbstractThis paper explores the idea that in capitalist economies, external markets are the driving force behind long-run economic growth. To this end, a model is developed so that the dynamics of external demand, consumer spending, capital accumulation, income distribution and capitalists’ net financial assets can be analysed together as a complete system. The model shows how, in the long run, if capitalists adjust spending to keep financial wealth at desired levels, and investment reacts to aggregate demand in a Harrodian fashion, then this can cause the rate of capital accumulation to gravitate towards the growth rate of external markets. This occurs even if external demand only accounts for a small share of total economic activity. Based on this framework, the paper argues for a reinterpretation of the relationship between profits and growth during the neoliberal period in the USA.
Preoperative assessment for percutaneous and open surgical arteriovenous fistula creation in patients for haemodialysis
Authors: Khawaja Aurang Z , Tullett Karen A J , Jones Robert G , Inston Nicholas G 
Published: August 2019

Abstract
Preoperative assessment prior to surgical arteriovenous fistulas (AVFs) including ultrasound-guided mapping has been shown to have beneficial effects on their immediate success as well as early outcomes. This has led to their wide acceptance and adoption however clinical practice criteria is variable and is reflected in variabilities in practice. When transposing this to percutaneously created endovascular AVFs (endoAVFs), variable preoperative assessment criteria could equally result in variable practice and potentially subsequent and expectant outcomes. We aimed to review literature on reported validated methodologies and workflows of preoperative assessment for surgical AVF creation as reported in highest levels of available evidence, specifically randomized controlled trials. Published practice recommendations and guidelines on best clinical practice as well as systematic reviews and meta-analyses of published studies were also reviewed. Data on practice methodology from identified trial publications and protocols was collated and a summative narrative synthesis was carried out which compared these methodologies to additional assessments that may be required when targeting assessment for percutaneous endoAVF formation, based on our units experience as part of an international multicentre trial. In this review we present a brief overview of published literature and guidelines and propose a unified and uniform workflow for preoperative assessment for surgical AVFs and endoAVFs to aide clinical and imaging practice.
A plasma proteogenomic signature for fibromuscular dysplasia
Authors: Olin Jeffrey W , Di Narzo Antonio F , d’Escamard Valentina , Kadian-Dodov Daniella , Cheng Haoxiang , Georges Adrien , King Annette , Thomas Allison , Barwari Temo , Michelis Katherine C , Bouchareb Rihab , Bander Emir , Anyanwu Anelechi , Stelzer Paul , Filsoufi Farzan , Florman Sander , Civelek Mete , Debette Stephanie , Jeunemaitre Xavier , Björkegren Johan L M , Mayr Manuel , Bouatia-Naji Nabila , Hao Ke , Kovacic Jason C 
Published: August 2019

AbstractAimsFibromuscular dysplasia (FMD) is a poorly understood disease that predominantly affects women during middle-life, with features that include stenosis, aneurysm, and dissection of medium-large arteries. Recently, plasma proteomics has emerged as an important means to understand cardiovascular diseases. Our objectives were: (i) to characterize plasma proteins and determine if any exhibit differential abundance in FMD subjects vs. matched healthy controls and (ii) to leverage these protein data to conduct systems analyses to provide biologic insights on FMD, and explore if this could be developed into a blood-based FMD test.Methods and resultsFemales with ‘multifocal’ FMD and matched healthy controls underwent clinical phenotyping, dermal biopsy, and blood draw. Using dual-capture proximity extension assay and nuclear magnetic resonance-spectroscopy, we evaluated plasma levels of 981 proteins and 31 lipid sub-classes, respectively. In a discovery cohort (Ncases = 90, Ncontrols = 100), we identified 105 proteins and 16 lipid sub-classes (predominantly triglycerides and fatty acids) with differential plasma abundance in FMD cases vs. controls. In an independent cohort (Ncases = 23, Ncontrols = 28), we successfully validated 37 plasma proteins and 10 lipid sub-classes with differential abundance. Among these, 5/37 proteins exhibited genetic control and Bayesian analyses identified 3 of these as potential upstream drivers of FMD. In a 3rd cohort (Ncases = 506, Ncontrols = 876) the genetic locus of one of these upstream disease drivers, CD2-associated protein (CD2AP), was independently validated as being associated with risk of having FMD (odds ratios  = 1.36; P = 0.0003). Immune-fluorescence staining identified that CD2AP is expressed by the endothelium of medium-large arteries. Finally, machine learning trained on the discovery cohort was used to develop a test for FMD. When independently applied to the validation cohort, the test showed a c-statistic of 0.73 and sensitivity of 78.3%.ConclusionFMD exhibits a plasma proteogenomic and lipid signature that includes potential causative disease drivers, and which holds promise for developing a blood-based test for this disease.
Reconsideration of a simple approach to quantile regression for panel data
Authors: Besstremyannaya Galina , Golovan Sergei 
Published: August 2019

Summary
This note discusses two errors in the approach proposed in Canay (2011) for constructing a computationally simple two-step estimator in a quantile regression model with quantile-independent fixed effects. Firstly, we show that Canay’s assumption about n/Ts → 0 for some s &gt; 1 is not strong enough and can entail severe bias or even the non-existence of the limiting distribution for the estimator of the vector of coefficients. The condition n/T → 0 appears to be closer to the required set of restrictions. These problems are likely to cause incorrect inference in applied papers with large n/T, but the impact is less in applications with small n/T. In an attempt to improve Canay’s estimator, we propose a simple correction that may reduce the bias. The second error concerns the incorrect asymptotic standard error of the estimator of the constant term. We show that, contrary to Canay’s assumption, the within estimator has an influence function that is not i.i.d. and this affects inference. Moreover, the constant term is unlikely to be estimable at rate $\sqrt{nT}$, so a different estimator may not be available. However, the issue concerning the constant term does not have an effect on slope coefficients. Finally, we give recommendations to practitioners and conduct a meta-review of applied papers that use Canay’s estimator.
Predicting Within- and Between-Year Variation in Activity of the Invasive Spotted Wing Drosophila (Diptera: Drosophilidae) in a Temperate Region
Authors: Leach Heather , Van Timmeren Steven , Wetzel Will , Isaacs Rufus 
Published: August 2019

AbstractInvasive insect pests can be challenging to manage because their recent arrival provides limited information on which to build predictive population models. The magnitude and timing of activity by the invasive vinegar fly, Drosophila suzukii, in crop fields has been unpredictable due to its recent arrival in many new regions of the world and changes in methods for its detection. Using 7 yr of consistent trapping of adults at four blueberry farms in Michigan, United States, we modeled the temporal and environmental factors influencing D. suzukii activity. We found that this pest established high levels within 2 yr of being detected, with peak fly activity continuing to increase. Fly activity timing and abundance were predicted by the annual number of days below 0°C, the number of winter and spring days above 10°C, and by the fly activity in the preceding year, providing support for overwintering in our region. We monitored larval infestation for 4 yr at these same sites and found a moderate positive correlation between larvae in fruit and adults in traps. Finally, we developed a generalized additive model to predict D. suzukii fly capture throughout the season based on relevant environmental factors and examined the relative timing and magnitude of activity under varying winter and spring temperature conditions. Our results suggest that D. suzukii activity is predictable and that environmental conditions can be used in temperate regions to provide regional risk warnings as a component of strategies to manage this invasive insect pest.
Combined single-session cardiovascular magnetic resonance: stress perfusion and three-dimensional pulmonary vein angiography for stratification of atrial fibrillation patients with chest pain syndromes prior to catheter ablation
Authors: Oebel Sabrina , Paetsch Ingo , Stegmann Clara , Kircher Simon , Sommer Philipp , Arya Arash , Lindemann Frank , Bollmann Andreas , Hindricks Gerhard , Jahnke Cosima 
Published: August 2019

Abstract

Aims
To determine the clinical utility of a combined single-session cardiovascular magnetic resonance (CMR) imaging protocol integrating adenosine stress perfusion and three-dimensional pulmonary vein angiography for stratification of atrial fibrillation (AF) patients referred for pulmonary vein isolation (PVI) and complaining about chest pain syndromes.

Methods and results
The preprocedural CMR examination (adenosine stress perfusion, late gadolinium enhancement, and three-dimensional pulmonary vein angiography) was performed in 357 consecutive AF patients with chest pain syndromes referred for PVI. Stress perfusion results were used for stratification: ischaemia positive patients underwent invasive coronary angiography, ischaemia negative patients underwent PVI, and follow-up/outcome data were collected (combined primary endpoint of cardiac death/non-fatal myocardial infarction). The integrated CMR protocol had a high success rate (356/357, 99.7%), a short total examination duration (<30 min in all patients), and delivered high-quality three-dimensional pulmonary vein angiography in all patients undergoing PVI (324/324, 100%). Variants of pulmonary vein anatomy were identified in 33% of all patients (117/357). Stress positivity (28/356, 8%) had a high positive predictive value for identification of obstructive coronary artery disease (86%), while stress negativity carried a low short-term event rate following PVI (cumulative 1-year event-free survival rate, 99.6%).

Conclusion
Combined single-session CMR as a routine diagnostic workup for AF patients with chest pain syndromes prior to PVI proved to represent a time-efficient and effective stratification tool.
Policing printers and booksellers before and after 1789: a case study in Bordeaux
Authors: McLeod Jane , Girard Renée 
Published: August 2019

Abstract
This article examines the Bordeaux bookseller and printer Arnaud-Antoine Pallandre’s two censorship trials in 1775 and 1790 to compare state–media relations during the late Bourbon monarchy and the French Revolution. An entourage of protectors kept Pallandre in business even though he flouted pre-revolutionary book trade legislation. After 1789, his printing and bookselling shop became a centre of pamphlet sales and counter-revolutionary gatherings that came under intense scrutiny by patriots in the clubs, the National Guard and the crowds, who pressured the municipal governments to end Pallandre’s trade in counter-revolutionary pamphlets. He eventually went to the guillotine in 1794. This article suggests that members of formerly privileged groups continued to wield considerable influence over printers and booksellers in France after 1789, making them objects of both government and popular censorship. In the struggle to achieve limits on a free press, printers and booksellers came to be regarded as individuals with public (potentially dangerous) political affiliations in a new way, a development that may help explain the high levels of media repression in the French Revolution.
Medicaid Contributes Substantial Costs to Dementia Care in an Ethnically Diverse Community
Authors: Zhu Carolyn W , Ornstein Katherine A , Cosentino Stephanie , Gu Yian , Andrews Howard , Stern Yaakov 
Published: August 2019

Abstract

Objectives
The main objective of this study was to estimate effects of dementia on Medicaid expenditures in an ethnically diverse community.

Methods
The sample included 1,211 Medicare beneficiaries who did not have any Medicaid coverage and 568 who additionally had full Medicaid coverage enrolled in the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multiethnic, population-based, prospective study of cognitive aging in northern Manhattan (1999–2010). Individuals’ dementia status was determined using a rigorous clinical protocol. Relationship between dementia and Medicaid coverage and expenditures were estimated using a two-part model.

Results
In participants who had full Medicaid coverage, average annual Medicaid expenditures were substantially higher for those with dementia than those without dementia ($50,270 vs. $21,966, p &lt; .001), but Medicare expenditures did not differ by dementia status ($8,458 vs. $9,324, p = .19). In participants who did not have any Medicaid coverage, average annual Medicare expenditures were substantially higher for those with dementia than those without dementia ($12,408 vs. $8,113, p = .02). In adjusted models, dementia was associated with a $6,278 increase in annual Medicaid spending per person after controlling for other characteristics.

Discussion
Results highlight Medicaid’s contribution to covering the cost of dementia care in addition to Medicare. Studies that do not include Medicaid are unlikely to accurately reflect the true cost of dementia.
Non-parametric spectral modelling of source parameters, path attenuation and site effects from broad-band waveforms of the Alborz earthquakes (2005–2017)
Authors: Ahmadzadeh Somayeh , Javan Doloei G , Parolai Stefano , Oth Adrien 
Published: August 2019

SUMMARYS-wave spectral amplitudes from 312 crustal earthquakes recorded at the Iranian National Broadband Seismic Network in the Alborz region between 2005 and 2017 are analysed in order to evaluate earthquake source parameters, path attenuation and site amplification functions using the non-parametric generalized inversion technique (GIT). We exploit a total number of 1117 seismograms with ML 3–5.6 in the frequency range 0.3–20 Hz. The evaluated non-parametric attenuation functions decay uniformly with distance for the entire frequency range and the estimated S-wave quality factor shows low Q values with relatively strong frequency dependence. We assume the omega-square source model to retrieve earthquake source parameters from the inverted source spectra. The obtained stress drops range from 0.02 to 16 MPa with a mean value of 1.1 MPa. Stress drop and radiated energy show fairly self-similar scaling with seismic moment over the available magnitude range; however, the magnitude range of this study is too narrow to draw a definite conclusion on source scaling characteristics. The obtained moment magnitude Mw and the local magnitude ML are linearly correlated and approximately equivalent in the range of Mw 3–4. For larger events, Mw generally underestimates ML by about 0.1–0.5 magnitude units. The estimated site amplification functions for horizontal component (GIT H) are nearly flat with no obvious pre-dominant frequency peaks for most stations, as expected for the sites of permanent broad-band seismic stations located on rock, though a few stations show amplification peaks from 1 to 8 Hz, with a maximum amplification of about a factor of 7 with respect to the reference site. The evaluated site responses for the vertical components present remarkable amplification or deamplification, leading to differences of the H/V amplitude levels in comparison with the GIT H amplification curves. The results of this study provide a valuable basis for predicting appropriate ground motions in a context of seismic hazard assessment.
Assessing the field of health policy and systems research using symposium abstract submissions and machine learning techniques
Authors: Macarayan Erlyn K , Balabanova Dina , Gotsadze George 
Published: August 2019

Abstract
The field of health policy and systems research (HPSR) has grown rapidly in the past decade. Examining recently aggregated data from the Global Symposia on Health Systems Research, a key global fora for HPSR convened by the largest international society—Health Systems Global (HSG)—provides opportunities to enhance existing research on HPSR capacity using novel analytical techniques. This addresses the demand not only to map the field but also to examine potential predictors of acceptance to, and participation at, these global conferences to inform future work and strategies in promoting HPSR. We examined data from the abstracts submitted for two Global Symposia on Health Systems Research in 2016 and 2018 by type of institution, countries, regional groupings and gender. After mapping hotspot areas for HPSR production, we then examined how the corresponding author’s characteristics were associated with being accepted to present at the Global Symposia. Our findings showed that submissions for the Global Symposia increased by 12% from 2016 to 2018. Submissions increased across all participant groups, in particular, the for-profit organizations and research/consultancy firms showing the highest increases, at 58% for both. We also found reduced submissions from high-income countries, whereas submissions from low- and middle-income countries (LMICs), Sub-Saharan Africa and Latin America, increased substantially revealing the inclusivity values of Symposium organizers. Submissions increased to a larger extent among women than men. Being a woman, coming from a high-income country and having multiple abstracts submitted were found to be significant predictors for an abstract to be accepted and presented in the Symposia. Findings provide critical baseline information on the extent of interest and engagement in a global forum of various institutions and researchers in HPSR that can be useful for setting future directions of HSG and other similar organizations to support the advancement of HPSR worldwide.
From Amsterdam to Bamako: a qualitative case study on diffusion entrepreneurs’ contribution to performance-based financing propagation in Mali
Authors: Gautier Lara , Coulibaly Abdourahmane , De Allegri Manuela , Ridde Valéry 
Published: August 2019

AbstractFor the past 15 years, several donors have promoted performance-based financing (PBF) in Africa for improving health services provision. European and African experts known as ‘diffusion entrepreneurs’ (DEs) assist with PBF pilot testing. In Mali, after participating in a first pilot PBF in 2012–13, the Ministry of Health and Public Hygiene included PBF in its national strategic plan. It piloted this strategy again in 2016–17. We investigated the interactions between foreign experts and domestic actors towards PBF diffusion in Mali from 2009 to 2018. Drawing on the framework on DEs (Gautier et al., 2018), we examine the characteristics of DEs acting at the global, continental and (sub)national levels; and their contribution to policy framing, emulation, experimentation and learning, across locations of PBF implementation. Using an interpretive approach, this longitudinal qualitative case study analyses data from observations (N = 5), interviews (N = 33) and policy documentation (N = 19). DEs framed PBF as the logical continuation of decentralization, contracting policies and existing policies. Policy emulation started with foreign DEs inspiring domestic actors’ interest, and succeeded thanks to longstanding relationships and work together. Learning was initiated by European DEs through training sessions and study tours outside Mali, and by African DEs transferring their passion and tacit knowledge to PBF implementers. However, the short-time frame and numerous implementation gaps of the PBF pilot project led to incomplete policy learning. Despite the many pitfalls of the region-wide pilot project, policy actors in Mali decided to pursue this policy in Mali. Future research should further investigate the making of successful African DEs by foreign DEs advocating for a given policy.