bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘ReConnect’: a model for working with persistent pain patients on improving sexual relationships
Authors: Edwards Sarah , Mandeville Anna , Petersen Katrine , Cambitzi Julia , Williams Amanda C de C , Herron Katherine 
Published: June 2019

Introduction: Many individuals with persistent pain experience difficulties with sexual function which are exacerbated by avoidance and anxiety. Due to embarrassment or shame, sexual activity may not be identified as a goal for pain management programmes (PMPs). In addition, clinicians can feel that they lack skills and confidence in addressing these issues. Methods: We sought to develop a biopsychosocial model for helping patients return to sexual activity and manage relationships in the context of pain management, known as ‘ReConnect’. The model amalgamates well-established methods from pain management and sex therapy to guide multidisciplinary team members. ReConnect comprises three components: (1) ‘cognitive and myth-busting’, (2) ‘sensations and feelings’ and (3) ‘action-experimentation’. We collected self-report data from 281 women and 92 men from our specialist PMP for chronic abdomino-pelvic. pain, including questions measuring interference with and avoidance of sex due to pain, and the Multi-dimensional Sexuality Questionnaire (MSQ) to measure anxiety about sexual activity. Results: The results show statistically significant improvements for anxiety, avoidance of sex and sexual interference. Using the ReConnect model to structure clinical work, pain management clinicians reported increased confidence in addressing sexual activity goals. Conclusion: By using the ReConnect model is a framework for clinicians to use to support sexual activity goals. It has demonstrated improvements in clinical outcomes such as anxiety around sex and interference of pain in sexual activity. We encourage its application in pain management services in both one-to-one and group sessions, as a method for encouraging pain patients to address this important area of life which can be adversely affected by pain.
Role of platelet-rich plasma in early osteoarthritis of knee joint: Experience from a tertiary care center in Pakistan
Authors: Rasheed Nusrat , Hafeez Kamran , Zaidi Itat Hussain , Askari Raza , Rasheed Naseem , Khani Ghulam Mustafa Kaim 
Published: June 2019

Purpose: Osteoarthritis is the most common articular disease. The aim of this study was to observe the outcome after intra-articular platelet-rich plasma (PRP) injection in our patients presenting with knee osteoarthritis. Methods: This study was conducted in Dow University of Health Sciences, Karachi, Pakistan, from December 2014 to December 2015. All patients between 35 years and 60 years of age diagnosed with grade I and II arthritis were included in the study. Three PRP injections were injected in the knees at 4-week interval. Patients were followed up in outpatient department (OPD) and were assessed for pain and physical activity associated with arthritis using the Western Ontario and McMaster University Arthritis Index (WOMAC) score at the time of induction in the study and at 6 months interval. Results: Two hundred fourteen patients with the mean age of 55.15 (±6.93) years were studied. Female to male ratio was 3:1. One hundred fifty-five patients were classified as having Kellgren–Lawrence grade 1 osteoarthritis, while 59 were grade 2. One hundred eighty-nine patients had clinical symptoms for less than 2 years and 25 for more than 2 years. Mean WOMAC score before the start of treatment was 83.05, and after 6 months, it was reduced to 38.84 which was statistically significant ( p = 0.000). WOMAC score was improved more in the subgroup with patients having symptoms less than 2 years ( p = 0.005). Three patients developed minor hyperemia which was managed conservatively with activity limitation and ice application, but none of the patient developed gross infection. Conclusion: The sequential use of PRP injection for the treatment of early osteoarthritis proved to be effective in our study.
Correlation of Physician-Assessed Psoriasis Area and Severity Index Scores With Patient-Reported Psoriasis Symptoms and Signs Diary Scores Among Patients With Moderate-to-Severe Psoriasis: Results From VOYAGE 1 and VOYAGE 2 Studies
Authors: Gordon Kenneth B. , Han Chenglong , Li Shu , You Yin , Song Michael , Fakharzadeh Steven , Crowley Jeffrey J. , Reich Kristian 
Published: June 2019

Background: Patient-reported and clinician-determined outcomes do not always correlate in clinical trials for psoriasis, even among those with clear skin. Objective: To compare clinical responses with patient-reported outcomes among patients with psoriasis enrolled in 2 phase 3, double-blind, controlled trials of guselkumab (VOYAGE 1 and VOYAGE 2). Methods: Overall, 1432 patients randomized to guselkumab, placebo, or adalimumab at baseline were included in the pooled patient population; measures were assessed at baseline and week 16. End points included proportions of patients achieving 100% improvement in their Psoriasis Area and Severity Index (PASI 100) score and summary scores = 0 on the Psoriasis Symptoms and Signs Diary (PSSD). Proportions of patients with PSSD symptom/sign summary scores = 0 and mean PSSD summary scores were summarized by PASI 100 status. Association between PASI and PSSD scores were evaluated using Pearson correlation coefficients. Results: Among week-16 PASI 100 responders, 46.8% and 34.1% reported PSSD symptom and sign summary scores = 0, respectively, and 30.9% and 49.0% reported minimal symptoms/signs (scores = 1 to <10), respectively; mean scores (scale 0-100) were 6.4 for symptoms and 5.8 for signs. Among PASI 100 nonresponders, only 11.1% (symptoms) and 7.5% (signs) reported PSSD summary scores = 0; mean scores were 25.7 and 26.7, respectively. Correlation coefficients between overall PASI response and PSSD scores were 0.63 (symptoms) and 0.68 (signs; both P < .0001). Conclusion: While PASI and PSSD scores were highly correlated and most PASI 100 responders reported no/minimal symptoms or signs at week 16, substantial discrepancies were found between complete clearance from the clinician’s view versus symptom/sign-free status from patients’ perspectives.
No evidence of Zika, dengue, or chikungunya virus infection in field-caught mosquitoes from the Recife Metropolitan Region, Brazil, 2015
Authors: Ramesh Anita , Jeffries Claire L. , Castanha Priscila , Oliveira Paula A. S. , Alexander Neal , Cameron Mary , Braga Cynthia , Walker Thomas 
Published: June 2019

Background: The Recife Metropolitan Region (RMR), north-eastern Brazil, was the epicentre of the 2015 Zika virus (ZIKV) epidemic, which was followed by a 2016 chikungunya virus (CHIKV) epidemic. It historically has amongst the highest incidence of dengue virus (DENV) infections and is the only remaining focus of lymphatic filariasis (LF) in Brazil. In early 2015, a molecular xenomonitoring surveillance project focused on Culex (Cx.) quinquefasciatus commenced to inform LF elimination activities. Aedes (Ae.) aegypti mosquitoes were also collected, concurrent with the first microcephaly cases detected in the RMR. In terms of the 2015 ZIKV epidemic, these are the earliest known field-collected mosquitoes, preserved for potential RNA virus detection, when ZIKV was known to be circulating locally. Methods: Adult mosquitoes were collected in two sites (0.4 km2) of Sítio Novo, Olinda, RMR, from July 22 to August 21, 2015. Mosquitoes were morphologically identified, sorted by physiological status, and pooled (up to 10 mosquitoes per house per day or week). RNA was extracted, reverse transcribed and the cDNA tested by real-time PCR. Results: A total of 10,139 adult female Cx. quinquefasciatus and 939 adult female Ae. aegypti were captured. All female Ae. aegypti specimens were included within 156 pools and screened for ZIKV, DENV and CHIKV. In addition, a sub-set of 1,556 Cx. quinquefasciatus adult females in 182 pools were screened for ZIKV. No evidence of infection with any of the three arboviruses was found. Conclusions: The absence of arbovirus detection may have been expected given the extremely restricted geographic area and collection of mosquitoes during a very short time period of peak mosquito abundance (July–September), but low arbovirus circulation (November–March). However, this study demonstrates the potential to retrospectively screen for additional unexpected pathogens in situations of rapid emergence, such as occurred during the outbreak of ZIKV in the RMR.
Prosocial Compliance in P2P Lending: A Natural Field Experiment
Authors: Du Ninghua , Li Lingfang , Lu Tian , Lu Xianghua 
Published: June 2019

We implement behavioral mechanisms in a natural field experiment to increase loan repayment rates on a peer-to-peer (P2P) lending website. The results show that text message reminders that convey lenders’ positive expectations considerably increase the likelihood that borrowers will repay their loans, whereas reminders emphasizing the adverse consequences of failure to repay loans do not have enduring effects. Our experiment results in an increase in loan repayments in the sample period. In addition, our reminders are cost-free to implement, showing the potential importance of such interventions in enhancing prosocial compliance in P2P lending. This paper was accepted by John List, behavioral economics.
Perceptions of Constipation Among the General Public and People With Constipation Differ Strikingly From Those of General and Specialist Doctors and the Rome IV Criteria
Authors: Dimidi Eirini , Cox Camilla , Grant Robert , Scott S. Mark , Whelan Kevin 
Published: June 2019

OBJECTIVES:
To compare the perceptions of constipation among the general population (with and without constipation), general and specialist doctors, and the Rome IV criteria.

METHODS:
A cross-sectional survey using a self-administered questionnaire where participants were asked to report symptoms perceived to be most important for a diagnosis of constipation. Participants also judged 10 case studies in which constipation was either present or absent according to Rome IV criteria.

RESULTS:
Two thousand five hundred fifty-seven members of the general population (934 with self-reported constipation and 1,623 without constipation), 411 general practitioners (GPs) and 365 gastroenterology specialists completed the questionnaire. Of the 934 with self-reported constipation, 877 (94%) met Rome IV criteria for functional constipation, whereas of the 1,623 who did not self-report constipation, 473 (29%) actually met Rome IV criteria. Infrequent bowel movements were perceived as important for diagnosing constipation by less than a third of the constipated general population (26%), compared with 41% of GPs and 65% of specialist doctors (P < 0.001). Principal component analysis revealed 7 symptom clusters, with most symptoms not being part of formal diagnostic criteria. Using case studies, correct diagnosis of constipation ranged from 99% down to as low as 39%, depending upon the number and type of symptom present.

DISCUSSION:
The general population's perceptions of constipation differ strikingly from those of GPs and specialist doctors, and there is limited agreement between public perceptions of constipation and Rome IV criteria. These findings emphasize the need to educate doctors and the general population regarding the symptoms of constipation, and realign diagnostic criteria to address those symptoms patients perceive to be important.
Abordaje de la desnutrición en las cátedras de Pediatría. Lectura comparada de materiales escritos para la enseñanza de las universidades públicas argentinas
Authors: Itharte Marcelo 
Published: June 2019

Este artículo procede de una investigación realizada como trabajo final para la Maestría en Docencia Universitaria de la Facultad de Humanidades y Ciencias de la Universidad Nacional del Litoral. Su objetivo fue analizar los libros de texto utilizados para la enseñanza de la desnutrición, en las cátedras de Pediatría, de las Facultades de Medicina de cinco universidades públicas argentinas.
Una primera hipótesis sostiene que los libros de texto dan cuenta de una perspectiva biologicista que responde al modelo médico hegemónico, representando esta situación una discrepancia con la finalidad explicitada en los planes de estudio centrados en el modelo médico social. Las cátedras de Pediatría estudiadas no cuentan con un instrumento de análisis que les permita un enfoque evaluativo del material de enseñanza. La mayoría de los libros de texto utilizados no poseen un abordaje interdisciplinario adecuado de acuerdo con el nuevo paradigma de formación de recurso humano.
Palabras claves: educación médica - desnutrición – modelo médico hegemónico – modelo médico social– evaluación libros de textos
Abstract
This article proceeds from a research made as a final work for a Master Degree in University Teaching at Facultad de Humanidades y Ciencias at Universidad Nacional del Litoral. The main objective was to analyze written publications that are used for teaching malnutrition in Pediatric chairs at Medicine Faculty of five Argentinean public universities.
The hypothesis is that written publication for teaching have a biologist perspective that responds to hegemonic medical model, what represents a discrepancy with the purpose specified in the curricula focused on the social medical model. The Pediatric chairs studied do not have an instrument of analysis that allows them to have an evaluation perspective of teaching material. Most of the written publications used do not have an adequate interdisciplinary approach regarding to the new paradigm of human resources training.
Keywords: medical education – malnutrition – hegemonic medical model – social medical model – written teaching publications evaluation
Creating school songs from themes of Contemporary Turkish Music<p>Çağdaş Türk Müziği temalarından okul şarkısı oluşturma
Authors: Şimşek Peyruze Rana , Bilen Şermin 
Published: June 2019

Adapted, imitation, anonymous and Turkish school music songs are sources of music education repertoire. Adaptation songs are usually formed by writing lyrics to the music of foreign nations. The songs created from classical works are also categorized under this title. Contemporary Turkish music works can also take part in this extent. In the study used survey method, 25 classical music pieces have been listened to 321 students from five secondary schools in Buca/ Izmir, and it has been reached 10 most favorite works in line with “Liking Form” in 3 point likert scale. One of them is Telli Turna Suite’s third part composed by Nevit Kodallı who is one of the Contemporary Turkish Music composers. It is aimed to make formal and harmonic analysis of the suite, to write lyrics to theme of suite, and to create a school song with piano accompaniment. In the process of creating songs, it is included measurement system, tonal information, formal information, harmonic progression and modulation points categories. In the process of writing lyrics for the theme, we tried to stick to the rules of prosody as much as possible. Two different piano accompaniments are designed for the song. The first of them is designed as a studying accompaniment and the other one is designed as a concert accompaniment. It is thought this song can make an important contribution to educational music repertoire. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetUyarlama şarkılar, öykünme şarkılar, anonim şarkılar ve Türk okul müziği şarkıları müzik eğitimi dağarının kaynaklarıdır. Uyarlama şarkılar, genellikle yabancı ulusların müziklerine söz yazılarak oluşturulmaktadır. Klasik eserlerden oluşturulan şarkılar da bu grup altında toplanmaktadır. Çağdaş Türk müziği eserleri de bu kapsam içinde yer alabilir. Tarama yöntemi kullanılan araştırmada, İzmir’ in Buca ilçesinde bulunan beş ortaokuldan 321 öğrenciye, 25 klasik müzik eseri dinletilmiş, üçlü likert tipindeki “Beğeni Formu” doğrultusunda, en çok beğenilen 10 eser seçilmiştir. Bu eserlerden biri, Çağdaş Türk Müziği bestecilerinden Nevit Kodallı’ nın Telli Turna Süiti’ nin üçüncü bölümüdür. Bu çalışmanın amacı, süitin temasının armonik ve biçimsel analizinin yapılması ve temaya söz yazılarak piyano eşlikli bir okul şarkısı oluşturulmasıdır. Şarkıları oluşturma aşamasında, eserin biçimsel ve armonik analizi yapılmış ve ölçü sistemi, ton bilgisi, biçim bilgisi, akor kurulumları-bağlantıları ve modülasyon noktaları kategorilerine yer verilmiştir. Temaya söz yazımı sürecinde, prozodi kurallarına olabildiğince bağlı kalınmaya çalışılmıştır. Şarkı için iki farklı eşlik önerisi sunulmuş, önerilerden ilki çalışma eşliği, ikincisi konser eşliği olarak tasarlanmıştır. Bu şarkı örneğinin eğitim müziği dağarına önemli bir katkısı olabileceği düşünülmektedir.
Pengaruh Pemberian Minuman Karbohidrat Dan Protein Whey Pra Operasi Terhadap Kadar C- Reactive Protein Pasca Operasi Pada Pasien Mastektomi
Authors: Andreanto Erwin Santoso , Primatika Aria Dian , Pujo Jati Listiyanto 
Published: June 2019

Latar belakang : CRP adalah protein fase akut yang kadarnya dalam darah sangat berkaitan erat dengan respon inflamasi akut yang terjadi.Tindakan pembedahan dan puasa yang berkepanjangan menyebabkan pelepasan sitokin-sitokin proinflamasi dan mediator inflamasifaseakut melalui proses yang rumit.Tujuan : Membuktikan pengaruh pemberian minuman karbohidrat dan protein whey praoperasi terhadap kadar CRP pascaoperasi pada pasien mastektomi.Metode : Penelitian jenis uji klinis acak terkontrol. Sampel penelitian sebanyak 26 dibagi menjadi 2 kelompok. Kelompok perlakuan (13 sampel) diberikan 400 mL minuman karbohidrat dan protein whey malam sebelum operasi dan 200 mL 4 jam sebelum operasi. Kelompok kontrol diberikan air mineral dengan jumlah dan waktu pemberian yang sama dengan kelompok perlakuan. Kedua kelompok diperiksa kadar CRP pra dan pascaoperasi.Hasil : Terdapat perbedaan bermakna ( p = 0,001) pada kadarCRP pascaoperasi antara kelompok kontrol yaitu 7,62 ± 2,074 dibandingkan dengan CRP pascaoperasi kelompok perlakuan yaitu 2,81 ± 2,920. Selain itu juga terdapat perbedaan yang bermakna (p = 0,000) dalam selisih kadar CRP praoperasi dan pascaoperasi pada kelompok kontrol yaitu 5,36 ± 0,535 dibandingkan dengan kelompok perlakuan yaitu 0,89 ± 0,938.Kesimpulan : Pemberian minuman karbohidrat dan protein whey pra operasi terbukti menurunkan respon inflamasi fase akut pascaoperasi, yang tergambar dari peningkatan kadar CRP pascaoperasi yang lebih rendah pada kelompok perlakuan dibandingkan dengan kelompok kontrol.
PERCEPÇÃO AMBIENTAL ACERCA DA TRÍPLICE EPIDEMIA (DENGUE-CHIKUNGUNYA-ZIKA) E SUA RELAÇÃO COM OS RESÍDUOS SÓLIDOS
Authors: Silva André Vinícius Bezerra de Andrade , Brandão Camilo Rafael Pereira , Vitória Nadja Santos 
Published: June 2019

Percepção Ambiental pode ser definida como o modo do ser humano perceber o ambiente em que está inserido, de maneira que possa proteger e preservá-lo. O ano de 2016 foi marcado pela tríplice epidemia (Dengue-Zika-Chikungunya), que são exemplos de Doenças Tropicais, causadas pelo mosquito Aedes aegypti. Nesse sentido, o objetivo deste estudo foi investigar a percepção ambiental da comunidade do Povoado Juá em relação à prevalência dessas doenças, identificando quais os métodos de informação e prevenção mais utilizados pelos entrevistados na localidade, buscando associá-las ao destino incorreto dos resíduos sólidos gerados na região. Tais resultados permitiram conhecer o posicionamento da população diante dessa situação, onde 72% dos entrevistados souberam reconhecer pelo menos uma das três doenças anteriormente citadas, 81% identificaram corretamente o vetor das mesmas e 94% das respostas apontaram que é importante realizar a separação do lixo.

Palavras-chave: Educação Ambiental. Doenças Tropicais. Desenvolvimento Sustentável. Lixo.
Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia
Authors: Carlin Dan , Halevi Alexandra E. , Ewan Eric E. , Moore Amy M. , Cavalli Valeria 
Published: June 2019

AbstractNeurons of the PNS are able to regenerate injured axons, a process requiring significant cellular resources to establish and maintain long-distance growth. Genetic activation of mTORC1, a potent regulator of cellular metabolism and protein translation, improves axon regeneration of peripheral neurons by an unresolved mechanism. To gain insight into this process, we activated mTORC1 signaling in mouse nociceptors via genetic deletion of its negative regulator Tsc2. Perinatal deletion of Tsc2 in nociceptors enhanced initial axon growth after sciatic nerve crush, however by 3 d post-injury axon elongation rate became similar to controls. mTORC1 inhibition prior to nerve injury was required to suppress the enhanced axon growth. Gene expression analysis in purified nociceptors revealed that Tsc2-deficient nociceptors had increased activity of regeneration-associated transcription factors (RATFs), including cJun and Atf3, in the absence of injury. Additionally, nociceptor deletion of Tsc2 activated satellite glial cells and macrophages in the dorsal root ganglia (DRG) in a similar manner to nerve injury. Surprisingly, these changes improved axon length but not percentage of initiating axons in dissociated cultures. The pro-regenerative environment in naïve DRG was recapitulated by AAV8-mediated deletion of Tsc2 in adult mice, suggesting that this phenotype does not result from a developmental effect. Consistently, AAV8-mediated Tsc2 deletion did not improve behavioral recovery after a sciatic nerve crush injury despite initially enhanced axon growth. Together, these data show that neuronal mTORC1 activation induces an incomplete pro-regenerative environment in the DRG that improves initial but not later axon growth after nerve injury.
Adiabated flowing streams in nozzles: influence of regular characteristics on relaxation steam formation
Authors: Chekh O. , Sharapov S. , Arsenyev V. 
Published: June 2019

Two-phase nozzles, in which the phase transition process takes place, can work in jet superchargers for various purposes, including jet thermal pumps (steam-water injectors) and thermal compressors. In such schemes of thermal transformers, the ejector performs the function of a preliminary compression stage in order to reduce the load on the compression of the working substance in the main compressor. The use of fluxes of boiling liquid as energy-efficient working fluids is inhibited due to the lack of a reliable description of the mechanism of their flow. Finding the dependence of the steam content on the pressure and temperature at the nozzle exit will make it possible to determine the variant of the initial parameters at which the overproduction of steam will be greatest. It is also worth determining the change in the velocity factor, as well as the change in the thrust of the nozzle in the studied range of parameters, in order to find out whether the pressure at the nozzle outlet is a determining factor when choosing the design parameters of the nozzles. The article proposes to investigate the boiling streams in such nozzles by the method of mathematical modeling using a model that takes into account the relaxation nature of vaporization. The study used a compressible two-phase medium model, a kinetic model of evaporation / condensation. The model also takes into account the dynamic and mechanical equilibrium of the process of evaporation-condensation. The calculations were performed using an Ansys CFX commercial CFD product. The value of the mean square relative error of pressure measurement does not exceed 0,119%. The average discrepancy between the obtained data between the mathematical model and the field experiment does not exceed 3%.