bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain management practices surrounding lumbar punctures in children: A survey of Canadian emergency physicians
Authors: Poonai Naveen , Brzozowski Victoria , Stang Antonia S. , Drendel Amy L. , Boisclair Philippe , Miller Michael , Harman Stuart , Ali Samina ,   Pediatric Emergency Research Canada (PERC)
Published: May 2018

AbstractObjectivesLumbar punctures (LPs) are painful for children, and analgesia is recommended by academic societies. However, less than one-third of pediatric emergency physicians (EPs) adhere to recommendations. We assessed the willingness to provide analgesia among pediatric and general EPs and explored patient and provider-specific barriers.MethodsWe surveyed physicians in the Pediatric Emergency Research Canada (PERC) or Canadian Association of Emergency Physicians (CAEP) databases from May 1 to August 1, 2016, regarding hypothetical scenarios for a 3-week-old infant, a 3-year-old child, and a 16-year-old child requiring an LP. The primary outcome was the willingness to provide analgesia. Secondary outcomes included the type of analgesia, reasons for withholding analgesia, and their perceived competence performing LPs.ResultsFor a 3-week old infant, 123/144 (85.4%) pediatric EPs and 231/262 (88.2%) general EPs reported a willingness to provide analgesia. In contrast, the willingness to provide analgesia was almost universal for a 16-year-old (144/144 [100%] of pediatric EPs and 261/262 [99.6%] of general EPs) and a 3-year-old (142/144 [98.6%] of pediatric EPs and 256/262 [97.7%] of general EPs). For an infant, the most common barrier cited by pediatric EPs was the perception that it produced additional discomfort (13/21, 61.9%). The same reason was cited by general EPs (12/31, 38.7%), along with unfamiliarity surrounding analgesic options (13/31, 41.9%).ConclusionCompared to a preschool child and adolescent, the willingness to provide analgesia for an LP in a young infant is suboptimal among pediatric and general EPs. Misconceptions and the lack of awareness of analgesic options should be targets for practice-changing strategies.
Stimulated generation: extraction of energy from balanced flow by near-inertial waves
Authors: Rocha Cesar B. , Wagner Gregory L. , Young William R. 
Published: May 2018

We study stimulated generation – the transfer of energy from balanced flows to existing internal waves – using an asymptotic model that couples barotropic quasi-geostrophic flow and near-inertial waves with $\text{e}^{\text{i}mz}$ vertical structure, where $m$ is the vertical wavenumber and $z$ is the vertical coordinate. A detailed description of the conservation laws of this vertical-plane-wave model illuminates the mechanism of stimulated generation associated with vertical vorticity and lateral strain. There are two sources of wave potential energy, and corresponding sinks of balanced kinetic energy: the refractive convergence of wave action density into anti-cyclones (and divergence from cyclones); and the enhancement of wave-field gradients by geostrophic straining. We quantify these energy transfers and describe the phenomenology of stimulated generation using numerical solutions of an initially uniform inertial oscillation interacting with mature freely evolving two-dimensional turbulence. In all solutions, stimulated generation co-exists with a transfer of balanced kinetic energy to large scales via vortex merging. Also, geostrophic straining accounts for most of the generation of wave potential energy, representing a sink of 10 %–20 % of the initial balanced kinetic energy. However, refraction is fundamental because it creates the initial eddy-scale lateral gradients in the near-inertial field that are then enhanced by advection. In these quasi-inviscid solutions, wave dispersion is the only mechanism that upsets stimulated generation: with a barotropic balanced flow, lateral straining enhances the wave group velocity, so that waves accelerate and rapidly escape from straining regions. This wave escape prevents wave energy from cascading to dissipative scales.
Direct numerical simulation of heat transfer from a cylinder immersed in the production and decay regions of grid-element turbulence
Authors: Paul I. , Papadakis G. , Vassilicos J. C. 
Published: May 2018

The present direct numerical simulation (DNS) study, the first of its kind, explores the effect that the location of a cylinder, immersed in the turbulent wake of a grid-element, has on heat transfer. An insulated single square grid-element is used to generate the turbulent wake upstream of the heated circular cylinder. Due to fine-scale resolution requirements, the simulations are carried out for a low Reynolds number. Three locations downstream of the grid-element, inside the production, peak and decay regions, respectively, are considered. The turbulent flow in the production and peak regions is highly intermittent, non-Gaussian and inhomogeneous, while it is Gaussian, homogeneous and fully turbulent in the decay region. The turbulence intensities at the location of the cylinder in the production and decay regions are almost equal at 11 %, while the peak location has the highest turbulence intensity of 15 %. A baseline simulation of heat transfer from the cylinder without oncoming turbulence was also performed. Although the oncoming turbulent intensities are similar, the production region increases the stagnation point heat transfer by 63 %, while in the decay region it is enhanced by only 28 %. This difference cannot be explained only by the increased approaching velocity in the production region. The existing correlations for the stagnation point heat transfer coefficient are found invalid for the production and peak locations, while they are satisfied in the decay region. It is established that the flow in the production and peak regions is dominated by shedding events, in which the predominant vorticity component is in the azimuthal direction. This leads to increased heat transfer from the cylinder, even before vorticity is stretched by the accelerating boundary layer. The frequency of oncoming turbulence in production and peak cases also lies close to the range of frequencies that can penetrate the boundary layer developing on the cylinder, and therefore the latter is very responsive to the impinging disturbances. The highest Nusselt number along the circumference of the cylinder is shifted 45 degrees from the front stagnation point. This shift is due to the turbulence-generating grid-element bars that result in the prevalence of intense events at the point of maximum Nusselt number compared to the stagnation point.
Agency Loss and the Strategic Redesign of the Presidential Office in Colombia
Authors: Mejía-Guinand Luis Bernardo , Botero Felipe , Solano Angélica 
Published: May 2018

AbstractPresidents rely on their trusted advisers to collect, analyze, coordinate, and present information in a timely fashion. However, Latin American presidents often fail to form majority governments and must use cabinet appointments to secure legislative coalitions to pursue their policies. This article suggests that presidents strategically redesign their executive offices to address the ministry drift. Presidents who can transform the organizations attached to their executive office have additional tools to monitor their ministers’ flexibility. The article argues that the greater the number of ministers in the cabinet from parties different from the president’s, the greater the transformations to the presidential office. Using time-series analysis, hypotheses are tested with an original dataset of organizational changes to the presidential center in Colombia, 1967–2015. The findings indicate that the percentage of ministers from other parties is a good predictor of the transformations undertaken in the executive office of the president.
Association between serum magnesium and blood lipids: influence of type 2 diabetes and central obesity
Authors: Yu Lianlong , Zhang Junli , Wang Liansen , Li Suyun , Zhang Qian , Xiao Peirui , Wang Kebo , Zhuang Maoqiang , Jiang Ying 
Published: May 2018

AbstractTo assess the changes in the relationship between serum Mg and blood lipids of Chinese adults with type 2 diabetes (T2D) or central obesity, a total of 8163 subjects (mean age 59·6 years, 54·9 % men) were analysed. Participants were classified according to blood Mg (below 0·65 mmol/l, 0·65–0·95 mmol/l and above 0·95 mmol/l), T2D (yes/no) and central obesity (yes/no). Blood lipids (TAG, total cholesterol (TC), HDL-cholesterol and LDL-cholesterol) were determined by standardised methods and conditions. A significant increase in blood lipids, with the exception of HDL-cholesterol, across progressive Mg groups in all subjects was noted (P<0·05). TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with central obesity compared with those without central obesity (P<0·05). A significant increase in TAG, TC and LDL-cholesterol across progressive Mg groups was observed in subjects without T2D (P<0·05). However, no significant change of HDL-cholesterol and LDL-cholesterol across progressive Mg groups was observed in subjects with T2D (P>0·05). TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D than those without T2D (P<0·05). Multivariable models for TAG and LDL-cholesterol failed to attain statistical significance in diabetics, by using a generalised linear or parsimonious model. TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D or central obesity. Blood lipids, with the exception of HDL-cholesterol, were associated with serum Mg, but this association was somehow influenced by T2D in LDL-cholesterol. In addition, multivariable models for both TAG and LDL-cholesterol failed to attain statistical significance among subjects with T2D, different from subjects without T2D.
Prospective association between adherence to dietary recommendations and incident depressive symptoms in the French NutriNet-Santé cohort
Authors: Adjibade Moufidath , Lemogne Cédric , Julia Chantal , Hercberg Serge , Galan Pilar , Assmann Karen E. , Kesse-Guyot Emmanuelle 
Published: May 2018

AbstractA posteriorihealthier dietary patterns and several nutrients have been associated with lower risks of depression in various studies; however, evidence is lacking with regard to the prospective association between adherence to nutritional recommendations (food-based and nutrient-based recommendations) and incident depression or depressive symptoms. In this study, we investigate such associations in the NutriNet Santé cohort. The study sample included 26 225 participants (aged 18–86 years) who were initially free of depressive symptoms. Adherence to nutritional recommendations was measured by four scores namely modified French Programme National Nutrition Santé-Guideline Score (mPNNS-GS), Alternative Healthy Eating Index-2010 (AHEI-2010), Probability of Adequate Nutrient Intake Dietary Score (PANDiet) and Diet Quality Index-International (DQI-I), using non-consecutive dietary record data during the first 2 years of follow-up (mean number of recording days=8,sd2). Depressive symptoms were defined by a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥17 for men and ≥23 for women. We used Cox proportional hazards models to estimate hazard ratios and 95 % CI, modelling the dietary scores as standardised continuous variables and as tertiles. Over a mean follow-up of 6 years, we identified 2166 incident cases of depressive symptoms. All dietary scores with the exception of the AHEI-2010 were significantly inversely associated with incident depressive symptoms. In the fully adjusted model, an increase of 1sdin the mPNNS-GS, PANDiet and DQI-I was, respectively, associated with an 8 % (95 % CI 4, 13), 5 % (95 % CI 1, 9) and 9 % (95 % CI 5, 13) reduction in the risk of depressive symptoms. Overall, these findings suggest that diet in accordance with national or international guidelines could have beneficial effects with regard to mental health.
The United States and the making of an Arctic nation
Authors: Nilsson Annika E. 
Published: May 2018

ABSTRACTThe United States has sometimes been called a reluctant Arctic actor, but during its chairmanship of the Arctic Council (2015–2017) the US engaged as an active proponent of Arctic cooperation, using the region as a showcase for strong global climate policy. This paper places US Arctic policy development during the Obama presidency within a longer time perspective, with a focus on how US interests towards the region have been formulated in policies and policy statements. The paper uses frame analysis to identify overarching discourses and discusses the extent to which certain themes and political logics recur or shift over time. It highlights economic development and national competitiveness as a prominent recurring frame, but also that the policy discourse has moved from nation-building and military security towards a broader security perspective, with attention to energy supply for the US, and more recently also to the implications of climate change. Over time, there is a clear shift from reluctance towards Arctic regional cooperation to embracing it. Moreover, it highlights how different stands in relation to climate change have affected Arctic cooperation in the past and may do so again in the future.
Comparing the Implications of Expanded Income-Based Measures of Living Standards with an Application to Older Australians
Authors: NAIDOO YUVISTHI 
Published: May 2018

AbstractThe standard of living of older people is a critical policy matter, given Australia's ageing population. Conventional living standard assessments continue to rely on disposable income as a defining indicator, despite it not encompassing the full range of potential consumption possibilities that affect an individual's economic living standard. This article proposes a series of three economic resource metrics that sequentially append the disposable income metric with the value of non-cash benefits and services arising from the receipt of public goods and/or services from home ownership in the form of a ‘full’ income metric, and then the inclusion of wealth in the form of two derived ‘potential consumption’ metrics. Using data from the Household, Income and Labour Dynamics in Australia Survey, the findings demonstrate that augmenting disposable income with income streams from non-cash services and annuitised wealth substantially improves the relative economic position of older Australians. It also highlights the heterogeneity in economic living standard outcomes for different demographic sub-groups of older people that would otherwise be drawn using a disposable income analytic lens. The article argues that an expanded economic resource perspective is necessary for informing ageing and social policy.
Networking, lobbying and bargaining for pensions: trade union power in the Norwegian pension reform
Authors: Grødem Anne Skevik , Hippe Jon M. 
Published: May 2018

AbstractNorway reformed its pension system in 2011, introducing a Swedish-style, NDC system. Contrary to expectations, the reform was largely supported by the dominant confederation of trade unions, the LO. In this article, we look at LO involvement in the process at different stages. Through qualitative interviews with key reform architects, we have traced the process between 2005 and 2008, emphasising actors, meeting places and interests. Starting from the insight that unions can influence through lobbying, bargaining and (the threat of) mobilising, we suggest that lobbying can be a mutual process, where parties and unions move each other’s positions. In addition, bargaining can take the form of behind-the-scenes cooperation, as well as of negotiations in the classic, Nordic-style industrial relations sense. Expanding on this framework, we suggest that the literature on pension reforms should pay more attention to negotiated and voluntary labour market occupational schemes, and to the importance of expertise and networks.
EarthN: A New Earth System Nitrogen Model
Authors: Johnson Benjamin W. , Goldblatt Colin 
Published: May 2018

AbstractThe amount of nitrogen in the atmosphere, oceans, crust, and mantle have important ramifications for Earth's biologic and geologic history. Despite this importance, the history and cycling of nitrogen in the Earth system is poorly constrained over time. For example, various models and proxies contrastingly support atmospheric mass stasis, net outgassing, or net ingassing over time. In addition, the amount available to and processing of nitrogen by organisms is intricately linked with and provides feedbacks on oxygen and nutrient cycles. To investigate the Earth system nitrogen cycle over geologic history, we have constructed a new nitrogen cycle model: EarthN. This model is driven by mantle cooling, links biologic nitrogen cycling to phosphate and oxygen, and incorporates geologic and biologic fluxes. Model output is consistent with large (2‐4x) changes in atmospheric mass over time, typically indicating atmospheric drawdown and nitrogen sequestration into the mantle and continental crust. Critical controls on nitrogen distribution include mantle cooling history, weathering, and the total Bulk Silicate Earth + atmosphere nitrogen budget. Linking the nitrogen cycle to phosphorous and oxygen levels, instead of carbon as has been previously done, provides new and more dynamic insight into the history of nitrogen on the planet.
In Situ Quantitative Raman Detection of Dissolved Carbon Dioxide and Sulfate in Deep‐Sea High‐Temperature Hydrothermal Vent Fluids
Authors: Li Lianfu , Zhang Xin , Luan Zhendong , Du Zengfeng , Xi Shichuan , Wang Bing , Cao Lei , Lian Chao , Yan Jun 
Published: May 2018

AbstractCarbon dioxide emitted from hydrothermal vents, as an important part of the global carbon cycle, can directly affect hydrothermal ecosystems. However, traditional chemical analysis methods cannot directly measure the concentrations of dissolved CO2 in high‐temperature hydrothermal fluids. Although in situ mass spectrometry has been applied to the measurements of deep sea, it cannot be used to detect high‐temperature fluids. In this study, an in situ Raman quantitative method for measuring dissolved CO2 suitable for a hydrothermal environment is established. The Raman relative intensity of CO2 displayed a linear relationship with increasing concentration of CO2 under the investigated conditions (up to 300°C and 40 MPa), allowing this in situ measurement method to be applied to most hydrothermal fields worldwide. Moreover, we find that the quantitative calibration curve for
for high‐temperature and high‐pressure conditions is identical to that of
for room temperature and atmospheric pressure. The concentrations of CO2 in mid‐Okinawa Trough hydrothermal fluids determined by in situ Raman measurement are 188.4–532.3 mmol/kg, which are about 3 times higher than those obtained by traditional sampling methods (59–198 mmol/kg). However, the concentrations of
calculated from in situ Raman spectra were near zero, indicating that the in situ Raman measurement avoids hydrothermal fluids contaminated with seawater.
Reconfigurable elastomeric graded-index optical elements controlled by light
Authors: Angelini Angelo , Pirani Federica , Frascella Francesca , Descrovi Emiliano 
Published: May 2018

AbstractIn many optical applications, there is an increasing need for dynamically tunable optical elements that are able to shape the wavefront of light ‘on demand’. In this work, an elastomeric easy-to-fabricate optical element whose transmission functions can be reversibly phase configured by visible light is demonstrated. The light responsivity of proper azopolymers incorporated within an elastomeric matrix is exploited to induce a light-controlled graded refractive index (GRIN) distribution within the bulk compound. The induced refractive index distribution is continuous and conformal to the intensity profile of the illumination at moderate power. A 100 mW doubled-frequency Nd:YAG Gaussian beam focused to a 650 μm waist is shown to induce a maximum relative refractive index change of ~0.4% in the elastomeric matrix, with an approximately parabolic profile. The restoring characteristics of the elastomeric matrix enable full recovery of the initial homogeneous refractive index distribution within a few seconds when the incident laser is switched off. As an exemplary application, the configurable GRIN element is used in a microscope-based imaging system for light control of the effective focal length.
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
Authors: Wang Zhuo , Stuckey Daniel J. , Murdoch Colin E. , Camelliti Patrizia , Lip Gregory Y. H. , Griffin Martin 
Published: May 2018

AbstractCardiac fibrosis is implicit in all forms of heart disease but there are no effective treatments. In this report, we investigate the role of the multi-functional enzyme Transglutaminase 2 (TG2) in cardiac fibrosis and assess its potential as a therapeutic target. Here we describe the use a highly selective TG2 small-molecule inhibitor to test the efficacy of TG2 inhibition as an anti-fibrotic therapy for heart failure employing two different in vivo models of cardiac fibrosis: Progressively induced interstitial cardiac fibrosis by pressure overload using angiotensin II infusion: Acutely induced focal cardiac fibrosis through myocardial infarction by ligation of the left anterior descending coronary artery (AMI model). In the AMI model, in vivo MRI showed that the TG2 inhibitor 1–155 significantly reduced infarct size by over 50% and reduced post-infarct remodelling at 20 days post insult. In both models, Sirius red staining for collagen deposition and levels of the TG2-mediated protein crosslink ε(γ-glutamyl)lysine were significantly reduced. No cardiac rupture or obvious signs of toxicity were observed. To provide a molecular mechanism for TG2 involvement in cardiac fibrosis, we show that both TGFβ1-induced transition of cardiofibroblasts into myofibroblast-like cells and TGFβ1-induced EndMT, together with matrix deposition, can be attenuated by the TG2 selective inhibitor 1–155, suggesting a new role for TG2 in regulating TGFβ1 signalling in addition to its role in latent TGFβ1 activation. In conclusion, TG2 has a role in cardiac fibrosis through activation of myofibroblasts and matrix deposition. TG2 inhibition using a selective small-molecule inhibitor can attenuate cardiac fibrosis.
Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells
Authors: Sun Guangyong , Sun Xiaojing , Li Wei , Liu Kai , Tian Dan , Dong Yiran , Sun Xuelian , Xu Hufeng , Zhang Dong 
Published: May 2018

AbstractCD4+T-cell-converted CD4−CD8−double negative (cDNT) have strong suppressive activity in the maintenance of immune tolerance, whereas IL-2 promotes cDNT proliferation and enhances cDNT resistance to apoptosis. However, the intrinsic mechanisms that regulate the survival of cDNT are still unknown. Here we demonstrate that theOX40molecule was highly expressed on cDNT. The expression ofOX40was necessary to promote proliferation and inhibit apoptosis of cDNT in vivo and in vitro.OX40promoted the survival of cDNT by regulating the expression of Bcl-2, Bcl-xL, Survivin, and BCL2L11. Canonical NF-κB cell signaling played an important role in the transmission of essential division and survival signals throughOX40in cDNT. IL-2 promoted the survival of cDNT in part via elevating the expression of theOX40molecule. IL-2 promotedOX40expression via downregulating the PPARα expression. In conclusion, we elucidated thatOX40is a key molecule that regulates cDNT proliferation and survival. IL-2 promotedOX40expression by downregulating the PPARα binding to theOX40promoter, leading to the elevated expression of Bcl-2, Bcl-xL, and Survivin in cDNT, which finally resulted in the promoted proliferation and decreased apoptosis of cDNT.