bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1
Authors: Lorente Mar , García-Casas Ana , Salvador Nélida , Martínez-López Angélica , Gabicagogeascoa Estibaliz , Velasco Guillermo , López-Palomar Lucía , Castillo-Lluva Sonia 
Published: October 2019

ABSTRACT
Post-translational modifications directly control protein activity and, thus, they represent an important means to regulate the responses of cells to different stimuli. Protein SUMOylation has recently been recognised as one such modification, and it has been associated with various diseases, including different types of cancer. However, the precise way that changes in SUMOylation influence the tumorigenic properties of cells remains to be fully clarified. Here, we show that blocking the SUMO pathway by depleting SUMO1 and UBC9, or by exposure to ginkgolic acid C15:1 or 2-D08 (two different SUMOylation inhibitors), induces cell death, also inhibiting the invasiveness of tumour cells. Indeed, diminishing the formation of SUMO1 complexes induces autophagy-mediated cancer cell death through increasing the expression of Tribbles pseudokinase 3 (TRIB3). Moreover, we found that blocking the SUMO pathway inhibits tumour cell invasion by decreasing RAC1 SUMOylation. These findings shed new light on the mechanisms by which SUMO1 modifications regulate the survival, and the migratory and invasive capacity of tumour cells, potentially establishing the bases to develop novel anti-cancer treatments based on the inhibition of SUMOylation.
MANGROVE BRACHYURAN CRABS IN WORI, NORTH SULAWESI, INDONESIA
Authors: Pratiwi Rianta , Widyastuti Ernawati 
Published: October 2019

The study for faunal diversity from mangrove sites in Wori were very less work carried out, especially on brachyuran crab taxa. Healthy mangrove forests provide a critical for many species of Crabs in intertidal and estuarine areas are keys to healthy marine ecology. Mangroves are the most suitable feeding, breeding and nursery grounds for crabs and other crustaceans. In this study, the habitat distribution and diversity of crabs in Wori mangrove environment was recorded from October 2015 and August 2016. In view of the significance of the mangrove habitat, in present study we selected three station with different habitat specifications as in Wori Seaward (WSW), Wori Middle zone (WMZ) and Wori Landward (WLW). Total 15 species and 307 individuals of brachyuran crabs were recorded belonging to 10 genera and 6 families. Crabs belonging to family Sesarmidae was most dominant with 7 species. The other major outcome of study was maximum diversity was found at Wori Landward (WLW) site with 13 species, followed by Middle Zone (WMZ) site with 11 species and Wori Seaward (WSW) site with 10 species.
I. I. Dedov, V. I. Dedov. Hormonal Biorhythms
Authors: Lyashuk P M , Pishak V V 
Published: October 2019

There are many different, mostly popular, sometimes sensational publications dedicated to biorhythms in our lives. The peer-reviewed monograph summarizes literature data and the results of our own studies on the nature of the rhythmic functioning of various parts of the neuroendocrine system and the role of hormone biorhythms in the development of endocrinopathies. The authors went beyond the title of the book, since biorhythms are only a special case of a wider dependence of life processes on time.
The monograph consists of a preface, introduction, 4 chapters, conclusion and list of references. The introduction substantiates the relevance of the topic and clearly defined tasks. The material of each chapter is presented at the modern level of knowledge with an analysis of extensive, mainly foreign, literature.
The Future of Central Banking
Authors: Yamaoka Hiromi 
Published: October 2019

AbstractCompared to the history of money and banking, the history of central banking is fairly brief and has been influenced by the development of modern nation states, by the economic environment and by technological advances. Accordingly, on-going innovations in digital technologies and the globalization of the economy are expected to have significant impacts on central banking in the future. Since all the core activities of central banking, such as the issuance of money, the operation of settlement systems, its function as lender of last resort and its monetary policy, are based upon “trust”, its history has been, and its future will also be, closely linked to the most efficient framework in terms of building trust and reflecting changing technological and institutional conditions. Even though digital innovation may influence the styles of central banks in the future, the relevance and effectiveness of their payment and settlement infrastructures, their function as lenders of last resort and their monetary policies will be maintained. Besides, the need for risk-free central bank money will remain strong on account of its capacity to reduce risks in economic transactions, and central banks will have to continue making efforts to meet these demands through the enhancement of the utility of their infrastructure, including real-time gross settlement systems. Regarding central bank digital currencies, many issues require further examination. The future of central banking will be closely interlinked with that of nation states and depends on its capacity to identify the ideal mode of utilizing information and data in the economy.
Modellbasierte Online-Trajektorienplanung für zeitoptimale Rennlinien
Authors: Gundlach Ingmar , Konigorski Ulrich 
Published: October 2019

Zusammenfassung
Der Beitrag beschreibt eine zeitoptimale Trajektorienplanung, die eine simultane Quer- und Längsplanung auf Basis eines nichtlinearen Einspurmodells durchführt. Das Optimierungsproblem wird vom Zeit- in den Ortsbereich transformiert. Die Planung wird sowohl für Rundkurse als auch zur zyklischen Planung mit statischen Objekten eingesetzt. Neben der Rundenzeit stehen Komfort und Rechenzeit im Fokus.
Curing behaviors, mechanical properties, dynamic mechanical analysis and morphologies of natural rubber vulcanizates containing reclaimed rubber
Authors: Zhao Xipo , Hu Huan , Zhang Dengke , Zhang Zhen , Peng Shaoxian , Sun Yiming 
Published: October 2019

AbstractGround tire rubber (GTR) with crosslinked structure shows hardly any plasticity and processability, giving rise to its relatively poor properties. The thermal-mechanical shearing devulcanization can effectively break the three-dimension crosslinked network structure and restore a certain extent of plasticity and processability. In this work, reclaimed rubber (RR) was obtained by thermal-mechanical shearing devulcanization as a potential filler for natural rubber. The vulcanization process, mechanical properties, microstructure of RR/natural rubber (NR) compounds composites were investigated. It was found that the NR vulcanizates containing 30 phr of RR as filler showed the higher tensile strength and elongation at break. Microstructural characterization analysis on a sample containing 30 phr of RR revealed the existence of strong interactions between the natural rubber matrix and RR, suggesting that RR and NR appeared to be well-matched, undergoing simultaneous curing and forming a continuous phase.
Application of antioxidant and ultraviolet absorber into HDPE: Enhanced resistance to UV irradiation
Authors: Jiang Tiankai , Qi Yanli , Wu Yuchen , Zhang Jun 
Published: October 2019

AbstractHerein, high density polyethylene (HDPE) matrix was applied as the polymer matrix for its excellent overall performance and low price. In the study, antioxidants (0.5 phr) and ultraviolet absorber (1 phr) were added into the polymer matrix (100 phr) to investigate their influence on UV resistance, respectively. The macroscopic properties and microstructure changes of the samples were both investigated through the characterizations of Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), mechanical properties and thermogravimetric analysis (TGA). This work also conceived the three methods of capturing free radicals generated by photoaging, decomposing peroxides generated by photoaging, and absorbing ultraviolet light to achieve anti-aging effects. The results showed that the UV absorber improves the UV resistance of the material better than the antioxidant. After irradiation for 600 h under the aging condition of 0.51 w/m2@λ = 340 nm, the samples added with UV absorber also still maintain their mechanical properties at a high level. For comparison, the samples added with antioxidants presents poor mechanical properties only after irradiation for 200 h. Besides, the crystallinity of HDPE and HDPE added with antioxidant significantly increased after irradiation, but the crystallinity of HDPE introduced with UV absorber presents slight changes before and after irradiation. Meanwhile, all the irradiated samples also maintained the original excellent thermal stability. According to the obtained results, the aging mechanism was also analyzed.
On a class of critical Robin problems
Authors: Leonardi Salvatore , Papageorgiou Nikolaos S. 
Published: October 2019

Abstract
We consider a nonlinear parametric Robin problem.
In the reaction, there are two terms, one critical and the other locally defined.
Using cut-off techniques, together with variational tools and critical groups, we show that, for all small values of the parameter, the problem has at least three nontrivial smooth solutions all with sign information, which converge to zero in

C
1

⁢

(

Ω
¯

)

{C^{1}(\bar{\Omega})}

as the parameter

λ
→

0
+

{\lambda\to 0^{+}}

.
„Neue Zeitungen“ über Ungarn. Ein frühneuzeitliches Informations- und Unterhaltungsmedium
Authors: Lichnerová Lucia , Špániová Marta 
Published: October 2019

Zusammenfassung
„Neue Zeitungen“ sind ein Medium mit unregelmäßiger Periodizität, das sich im 16. Jahrhundert aus dem deutschsprachigen Raum in ganz Europa verbreitete und bis zum Ende des 17. Jahrhunderts dokumentiert ist. Die Veröffentlichung der „Neuen Zeitungen“ stieg mit der Nachfrage der potenziellen Leser nach Informationen über die Ereignisse in Europa und der ganzen Welt. Viele „Neue Zeitungen“ zu ungarischen Ereignissen wurden auf der Grundlage von Korrespondenzen und handgeschriebenen Meldungen erstellt, die entweder direkt an den Drucker oder an einen bekannten Adressaten geschickt wurden. In der Zeit von 1515 bis 1652 lassen sich etwa neunzig erhaltene „Neue Zeitungen“ zu Ereignissen in Ungarn identifizieren. Diese Publikationen stammen von mehr als fünfzig Druckern, die in 29 Städten in Deutschland, Österreich, Frankreich, Schlesien, Böhmen und Ungarn tätig waren. Eine geografische Verknüpfung zwischen dem Ort des Ereignisses, dem Ort der Entstehung des Berichts und dem Ort der Veröffentlichung kann nur in Ausnahmefällen ermittelt werden. Sehr häufig wurden dieselben Zeitungen mit identischen oder fast identischen Inhalten gleichzeitig an verschiedenen Orten veröffentlicht. Häufige Nachdrucke von „Neuen Zeitungen“ sind in vielen Fällen die einzige Informationsquelle über die Existenz von nicht erhaltenen Erstausgaben. „Neue Zeitungen“ wurden hauptsächlich von den Druckern, Verlegern, Verfassern oder Boten vertrieben. „Neue Zeitungen“ zu ungarischen Ereignissen enthielten vor allem politische Berichte, aber auch Nachrichten über Wunder und Naturkatastrophen. „Neue Zeitungen“ können deshalb mit heutigen Boulevardzeitschriften verglichen werden. Die Glaubwürdigkeit der „Neuen Zeitungen“ zu ungarischen Ereignissen wurde mit Hilfe eines vertrauten Autors, Titels, Druckers oder Augenzeugen der beschriebenen Ereignisse verstärkt. Die „Neuen Zeitungen“ erfüllten die Funktion eines Informations-, Bildungs- und Unterhaltungsmediums, aus dem sich später die periodische Presse entwickelte.
Language policy and language planning in mainland Southeast Asia: Myanmar and Lisu
Authors: Bradley David 
Published: October 2019

Abstract
Most nations in mainland Southeast Asia and elsewhere have one national language as a focus of national identity and unity, supported by a language policy which promotes and develops this language. Indigenous and immigrant minority groups within each nation may be marginalized; their languages may become endangered. Some of the official national language policies and ethnic policies of mainland Southeast Asian nations aim to support both a national language and indigenous minority languages, but usually the real policy is less positive. It is possible to use sociolinguistic and educational strategies to maintain the linguistic heritage and diversity of a nation, develop bilingual skills among minority groups, and integrate minorities successfully into the nations where they live, but this requires commitment and effort from the minorities themselves and from government and other authorities. The main focus of this paper is two case studies: one of language policy and planning in Myanmar, whose language policy and planning has rarely been discussed before. The other is on the Lisu, a minority group in Myanmar and surrounding countries, who have been relatively successful in maintaining their language.
Appendix bleeding with painless bloody diarrhea: A case report and literature review
Authors: Chen Wanqun , Qiu Hong , Yang Xiaojun , Zhang Jinwei 
Published: October 2019

Abstract
Appendix bleeding is an uncommon clinical phenomenon. In this article, we reported a case of appendix bleeding with painless bloody diarrhea. With the analysis of clinical features, clinical examination, experimental test and literature review, we diagnosed that the appendix bleeding might be caused by granulomatous appendicitis. This successfully cured case might be a reference for later diagnosis and treatment of appendix bleeding with painless bloody diarrhea.
The crystal structure of poly[(m4-4-bromoisophthalato-κ4
O: O′:O′′:O′′′)zinc(II)], C8H3BrO4Zn
Authors: Chang Xin-Hong 
Published: October 2019

Abstract
C8H3BrO4Zn, monoclinic, P21/c (no. 14), a = 4.7134(4) Å, b = 15.4354(13) Å, c = 12.0064(9) Å, β = 98.942(8)°, V = 862.89(12) Å3, Z = 4, R
gt(F) = 0.0445, wR
ref(F
2) = 0.1193, T = 292.67(10) K.
Crystal structure of cyclo[tetra(μ2-cyanido)-tetracyanido-bis(1,4,7,10-tetraazacyclododecane-κ4
N,N′,N′′,N′′′)dinickel(II)dipalladium(II)] hexahydrate, C24H52N16Ni2O6Pd2
Authors: Ha Kwang 
Published: October 2019

Abstract
C24H52N16Ni2O6Pd2, monoclinic, P21/c (no. 14), a = 8.6416(3) Å, b = 14.2237(5) Å, c = 15.5573(5) Å, β = 93.8054(12)°, V = 1908.02(11) Å3, Z = 2, R
gt(F) = 0.0312, wR
ref(F
2) = 0.0915, T = 223(2) K.
Hemispheric Asymmetry of Globus Pallidus Relates to Alpha Modulation in Reward-Related Attentional Tasks
Authors: Mazzetti Cecilia , Staudigl Tobias , Marshall Tom R. , Zumer Johanna M. , Fallon Sean J. , Jensen Ole 
Published: October 2019

Whereas subcortical structures such as the basal ganglia have been widely explored in relation to motor control, recent evidence suggests that their mechanisms extend to the domain of attentional switching. We here investigated the subcortical involvement in reward related top-down control of visual alpha-band oscillations (8–13 Hz), which have been consistently linked to mechanisms supporting the allocation of visuospatial attention. Given that items associated with contextual saliency (e.g., monetary reward or loss) attract attention, it is not surprising that the acquired salience of visual items further modulates. The executive networks controlling such reward-dependent modulations of oscillatory brain activity have yet to be fully elucidated. Although such networks have been explored in terms of corticocortical interactions, subcortical regions are likely to be involved. To uncover this, we combined MRI and MEG data from 17 male and 11 female participants, investigating whether derived measures of subcortical structural asymmetries predict interhemispheric modulation of alpha power during a spatial attention task. We show that volumetric hemispheric lateralization of globus pallidus (GP) and thalamus (Th) explains individual hemispheric biases in the ability to modulate posterior alpha power. Importantly, for the GP, this effect became stronger when the value saliency parings in the task increased. Our findings suggest that the GP and Th in humans are part of a subcortical executive control network, differentially involved in modulating posterior alpha activity in the presence of saliency. Further investigation aimed at uncovering the interaction between subcortical and neocortical attentional networks would provide useful insight in future studies.SIGNIFICANCE STATEMENTWhereas the involvement of subcortical regions into higher level cognitive processing, such as attention and reward attribution, has been already indicated in previous studies, little is known about its relationship with the functional oscillatory underpinnings of said processes. In particular, interhemispheric modulation of alpha band (8–13 Hz) oscillations, as recorded with magnetoencephalography, has been previously shown to vary as a function of salience (i.e., monetary reward/loss) in a spatial attention task. We here provide novel insights into the link between subcortical and cortical control of visual attention. Using the same reward-related spatial attention paradigm, we show that the volumetric lateralization of subcortical structures (specifically globus pallidus and thalamus) explains individual biases in the modulation of visual alpha activity.
PERFORMANCE OF EINKORN (Triticum monococcum L.) FLOUR IN THE MANUFACTURE OF TRADITIONAL TURKISH NOODLE
Authors: LEVENT Hacer 
Published: October 2019

Wheat flour used in traditional
Turkish noodle formulation was replaced with einkorn wheat flour (EWF) at 0,
20, 40, 60, 80 and 100% levels. The effects of EWF on some properties of noodle
samples were evaluated. The use of EWF resulted in significant increases in the
ash, protein, total phenolic content and antioxidant activity of noodle (P&lt;0.05). Volume and weight increase values increased as EWF ratio
increased. The lowest cooking loss value (5.85%) was obtained in noodle
containing 100 EWF%. Ca, Fe, Cu and Mg
contents of noodle samples increased 1.41, 3.27, 1.45 and 2.66 times at 100%
EWF compared to control sample. The use of 100% EWF decreased the taste and
chewiness scores of cooked noodle. Considering the physicochemical, sensory
properties and cooking quality of the samples, it can be concluded that the EWF
can be used successfully up to 60% level in the Turkish noodle formulation.
Genomics Analysis of L-DOPA Exposure inDrosophila sechellia
Authors: Lanno Stephen M , Lam Ivy , Drum Zachary , Linde Samuel C , Gregory Sara M , Shimshak Serena J , Becker Mariel V , Brew Kerry E , Budhiraja Aashli , Carter Eliza A , Chigweshe Lorencia , Collins Keagan P , Earley Timothy , Einstein Hannah L , Fan Angela A , Goss Sarah S , Hagen Eric R , Hutcheon Sarah B , Kim Timothy T , Mitchell Mackenzie A , Neri Nola R , Patterson Sean E , Ransom Gregory , Sanchez Guadalupe J , Wiener Bella M , Zhao Dacheng , Coolon Joseph D 
Published: October 2019

AbstractDrosophila sechellia is a dietary specialist fruit fly that evolved from a generalist ancestor to specialize on the toxic fruit of Morinda citrifolia. This species pair has been the subject of numerous studies where the goal has largely been to determine the genetic basis of adaptations associated with host specialization. Because one of the most striking features of M. citrifolia fruit is the production of toxic volatile compounds that kill insects, most genomic studies in D. sechellia to date have focused on gene expression responses to the toxic compounds in its food. In this study, we aim to identify new genes important for host specialization by profiling gene expression response to 3,4-dihydroxyphenylalanine (L-DOPA). Recent work found it to be highly abundant in M. citrifolia, critical for reproductive success of D. sechellia, and supplementation of diet with the downstream pathway product dopamine can influence toxin resistance phenotypes in related species. Here we used a combination of functional genetics and genomics techniques to identify new genes that are important for D. sechellia ecological adaptation to this new niche. We show that L-DOPA exposure can affect toxin resistance phenotypes, identify genes with plastic responses to L-DOPA exposure, and functionally test an identified candidate gene. We found that knock-down of Esterase 6 (Est6) in a heterologous species alters toxin resistance suggesting Est6 may play an important role in D. sechellia host specialization.
Genome Assemblies of Two Rare Opportunistic Yeast Pathogens:Diutina rugosa(syn.Candida rugosa) andTrichomonascus ciferrii(syn.Candida ciferrii)
Authors: Mixão Verónica , Saus Ester , Hansen Antonio Perez , Lass-Florl Cornelia , Gabaldón Toni 
Published: October 2019

AbstractInfections caused by opportunistic yeast pathogens have increased over the last years. These infections can be originated by a large number of diverse yeast species of varying incidence, and with distinct clinically relevant phenotypic traits, such as different susceptibility profiles to antifungal drugs, which challenge diagnosis and treatment. Diutina rugosa (syn. Candida rugosa) and Trichomonascus ciferrii (syn. Candida ciferrii) are two opportunistic rare yeast pathogens, which low incidence (&lt; 1%) limits available clinical experience. Furthermore, these yeasts have elevated Minimum Inhibitory Concentration (MIC) levels to at least one class of antifungal agents. This makes it more difficult to manage their infections, and thus they are associated with high rates of mortality and clinical failure. With the aim of improving our knowledge on these opportunistic pathogens, we assembled and annotated their genomes. A phylogenomics approach revealed that genes specifically duplicated in each of the two species are often involved in transmembrane transport activities. These genomes and the reconstructed complete catalog of gene phylogenies and homology relationships constitute useful resources for future studies on these pathogens.
A clinical and radiographical comparison of buccolingual crestal bone changes after immediate and delayed implant placement
Authors: Amin Viraj , Kumar Santosh , Joshi Surabhi , Hirani Tanvi , Shishoo Deepak 
Published: October 2019

Aim. The study aims to clinically and radiographically compare the bucco-lingual crestal bone changes after immediate and delayed placement of implants.
Methods. Two groups that consisted of fifty implants were considered for this study. In group A the implants were placed immediately post extraction, whereas, in group B implants placement were delayed by four to six weeks. All the implants were submerged within the alveoli confines. Bone grafts were only placed if the jumping distance was more than 1.5 mm. Barrier membrane was not placed in any of the cases. Bucco-lingual width was measured at the time of implant placement and during abutment placement after four to six weeks. Primary flap closure was ensured in all the cases.
Results. Thirty-one implants were placed in the mandible and nineteen were placed in the maxilla. All the implants achieved osseointegration. Immediate implant group showed a mean width of 8.80 mm (SD2.280) at the time of implant placement whereas, 7.60 mm (SD 1.871) after six months. Delayed implant group showed a mean width of 8.40 mm (SD1.673) at the time of implant placement, and 7.40 mm (SD 1.658) after six months. Intragroup showed statistically significant data (P<0.05). When the intergroup comparison of group 1 and group 2 was made at implant placement day and abutment placement day, it was found to be statistically non-significant.
Conclusion. This study suggests that circumferential defect heals on itself without any guided bone regeneration in both the groups. The data suggests that the healing in both the group were equally good. The equally good results suggest placing the implant immediately post extraction. This saves the cost, time and most importantly the need for an extra surgery.