bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effects of hydroxychloroquine on blood lipids and glycated haemoglobin: A randomised interventional study in patients with rheumatoid arthritis and systemic lupus erythematosus
Authors: Wahlin Bengt , Braune Antje , Jönsson Elias , Wållberg-Jonsson Solveig , Bengtsson Christine 
Published: October 2024

Introduction
Hydroxychloroquine (HCQ) exerts a large reduction of cardiovascular risk in patients with inflammatory diseases, but the mechanisms are not fully known. The aim of this study was to study potential mechanisms for this.

Methods
This interventional study (EudraCT 2014-005418-45) in 30 patients (23 with rheumatoid arthritis, 7 with systemic lupus erythematosus) investigates the effects of HCQ on cardiovascular risk factors and arterial stiffness in patients with inflammatory disease. Blood lipids, blood pressure, blood glucose, glycated haemoglobin (HbA1c) and arterial stiffness was assessed at initiation, after four weeks of treatment and after eight weeks of treatment with 200 mg HCQ daily.

Results
After four weeks of treatment with HCQ, total cholesterol had decreased from 5.4 mmol/L to 5.1 mmol/L (p<0.001), low-density lipoproteins from 3,0 mmol/L to 2.7 mmol/L (p<0.001) and apolipoprotein B from 0.96 g/L to 0.90 g/L (p<0.01). Those levels remained unchanged after eight weeks of treatment with HCQ. Levels of triglycerides, high-density lipoproteins and apolipoprotein A1 remained unchanged during the study. HbA1c decreased in most patients, especially in patients with high levels at start of HCQ, but increased HbA1c was seen in patients with low levels at start of treatment with HCQ. No significant effect was seen on blood pressure or any measure of arterial stiffness.

Conclusion
This study does not identify the mechanisms of cardiovascular risk reduction from HCQ. Arterial stiffness is not affected by HCQ. The impact of HCQ on HbA1c and blood lipids is rapid, but of modest magnitude, and these effects do not fully explain the reduced risk of cardiovascular disease seen in observational studies. The mechanisms of cardiovascular risk reduction from HCQ are yet not completely known.
A study of the clinical significance of mSEPT9 in monitoring recurrence and prognosis in patients with surgically treated colorectal cancer
Authors: Li Rong , Chen Jiaojiao , Shen Xin , Lin Yanping , Tang Jiadai , Xiong Guangrui , Zhang Ke , Xiang Mengying , Xie Lin , Hu Fengdi 
Published: October 2024

Objective
To explore the medical significance of methylated septin9 (mSEPT9) in monitoring recurrence and prognostic assessment in individuals with surgically treated colorectal cancer (CRC).

Methods
To investigate the role of Septin9 in colorectal cancer, we utilized the TIMER2.0 database to analyze its differential expression between tumor tissues and adjacent normal tissues. Colorectal cancer RNA-seq data from the TCGA database was downloaded and curated. The clinical relevance of mSEPT9 in colorectal cancer was explored by examining the correlation between Septin9 methylation levels and clinical characteristics using UALCAN and MethSurv software. Peripheral blood samples were obtained from 130 CRC subjects who underwent surgery for the detection of mSEPT9 and carcinoembryonic antigen (CEA) expression, along with collection of clinicopathological data such as age, gender, tumor site, TNM stage, and tumor differentiation. Patients were followed up for at least 3 years post-surgery until the death or final follow-up dates (31/12/2022). Additionally, peripheral blood samples were collected from 30 colorectal cancer surgery patients for mSEPT9 detection before and 7 days after surgery.

Results
Through bioinformatic database analysis, we identified higher expression levels of SEPT9 mRNA in most tumor tissues compared to normal tissues. Similarly, both paired and unpaired CRC tissues exhibited elevated expression of Septin9 when compared to normal tissues. Following GO and KEGG analysis of Septin9 target genes, we discovered their significant associations with ncRNA metabolic processes, ribonucleoprotein complex biogenesis, spliceosomes, and viral carcinogenesis. Furthermore, the overexpression of mSeptin9 was observed in CRC tissues, and it demonstrated a correlation with colon cancer staging and histologic classification. In our clinical sample study, The positive rate of mSEPT9 in CRC patients 7 days after surgery was 43.44% lower than that of preoperative. The differences in TNM stage, tumor differentiation degree, and preoperative CEA expression level between the preoperative mSEPT9 positive and negative groups of CRC were statistically significant (P < 0.05). Recurrence free survival (RFS) and overall survival (OS) were shorter in the preoperative mSEPT9-positive group, meaning preoperative mSEPT9 status was a risk factor for CRC recurrence and prognosis (P < 0.05). The sensitivity, specificity, and AUC value of preoperative mSEPT9 and CEA levels for predicting postoperative recurrence in CRC patients were 88% vs. 72%, 56.19% vs. 55.24%, and 0.721 vs. 0.636 respectively, well the AUC value of the combined prediction of postoperative recurrence was 0.758.

Conclusion
The detection of mSEPT9 combined with CEA in preoperative plasma helps predict recurrence in colorectal cancer patients.
Eating habits of students of health colleges and non-health colleges at the Northern Border University in the Kingdom of Saudi Arabia
Authors: Bayomy Hanaa E. , Alruwaili Shmoukh Mushref , Alsayer Razan Ibrahim , Alanazi Nuof Khalid , Albalawi Dana Ahmed , Al Shammari Khulud Hamed , Moussa Mariam Mahmoud 
Published: October 2024

Background
Eating habits are important determinants of health. Young adults who have recently transitioned to university life experience stress and lack of time, which are major risk factors for poor eating habits. This study’s objectives were to identify and compare eating habits between students at health and non-health colleges at Northern Border University (NBU), Saudi Arabia and to determine the relationship between students’ eating habits and their sociodemographic, lifestyle, and psychological factors.

Methods
This comparative cross-section study was conducted on 480 students equally from health and non-health colleges at NBU from March to April 2023. A pre-designed electronic questionnaire was used to collect data on students’ sociodemographic characteristics, eating habits, and diet-related psychological factors. Statistical analyses were carried out using STATA/SE version 11.2 for Windows.

Results
Unhealthy eating habits were reported by 44.6% and 41.3% of students at health and non-health colleges, respectively. Most students had irregular meals, skipped breakfast, ate fast food frequently, and consumed insufficient amounts of vegetables, fruits, and water. Parental separation, living away from family predisposed to unhealthy eating habits. Being 21–23 years old, playing sports, and high body mass index were linked to healthy eating habits. Psychological factors such as overeating until the stomach hurts and eating to feel happy were associated with unhealthy eating habits.

Conclusion
Unhealthy eating habits were prevalent among students at NBU irrespective of the type of study. Thus, implementing initiatives to promote nutrition and healthy eating habits within the university environment is crucial for health promotion and well-being among students.
Reference values of normal fetal ductus venosus Doppler flow measurements at 11–14 weeks of gestation
Authors: Li Shizhen , Wu Haifang , Zhu Linlin , Li Qi , Dong Xiangyi 
Published: October 2024

Objectives
To establish the reference range of normal fetal ductus venosus pulsatility index (DV PI) and ductus venosus (DV) blood flow velocity at 11–14 weeks of gestation.

Material and methods
Fetal ductus venosus Doppler flow was measured in singleton pregnancies attending our hospital for early pregnancy nuchal translucency (NT) screening between June 2021 and May 2022. All fetuses were followed up for pregnancy outcome using the following inclusion criteria: Singleton pregnancy; no maternal underlying diseases such as diabetes, hypertension, rheumatism, or other pregnancy complications; fetal crown-rump length (CRL) of 45 to 84 mm; normal NT screening ultrasound; no absent or reversed ductus venosus a-wave; no fetal structural abnormalities; no chromosomal abnormalities during follow-up; and good pregnancy outcome. DV PI, peak ventricular systolic velocity (S-wave), atrial systolic flow velocity (a-wave) and time-averaged maximum velocity (TAMXV) were recorded.

Results
The ductus venosus Doppler parameters of 224 fetuses which met the inclusion criteria were analysed. DV PI P5 and P95 ranged from 1.0007 and 1.3415 for a CRL of 45 mm to 0.9734 and 1.2115 for a CRL of 84 mm, indicating a statistically significant correlation with CRL. DV S-wave, a-wave, and TAMXV all increased as CRL increased, demonstrating a statistically significant correlation with CRL values.

Conclusions
A reference range of normal fetal ductus venosus Doppler spectral parameters at 11–14 weeks was established to provide a basis for further research into the clinical value of normal and abnormal DV PI values in relation to adverse pregnancy outcomes.
Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
Authors: Liu Yang , Liu Zhiyun , Ba Tejin , Zhang Shuanglin , Bao Bagenna , Mu Haibo , Kong Li , Zhang Feihu 
Published: October 2024

Abstract
Sepsis is a severe reaction of the body to an infection, presenting a critical medical crisis. It represents an imbalance between the body’s anti- and pro-inflammatory reactions. The occurrence of sepsis, which leads to multiple-organ failure and increased mortality, is marked by dysfunction in the lungs, heart, kidneys, and liver. The involvement of reactive oxygen species is believed to contribute to the progression of sepsis. Data suggest potential advantages of phenolic compounds derived from plants in combating sepsis. Plant polyphenols can be antioxidants by scavenging free radicals, chelating metals, and binding to proteins. In this research, silver nanoparticles (AgNPs) were produced by the aqueous extract of Cichorium intybus leaf for the purpose of treating sepsis-induced DNA harm. The recent study focused on the biological aspect including the cytotoxicity properties on normal (HUVEC) cell line. The AgNPs were analyzed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), fourier-transform infrared spectroscopy, X-ray powder diffraction, and UV-Vis. The TEM and SEM images of AgNPs exhibited the average size of 35.29 nm with spherical morphology. In the in vivo study, the animals were categorized into four groups: sepsis-induced, sham, AgNPs-20, and AgNPs-100. AgNPs treatment resulted in a significant decrease in tissues damage (p < 0.01). The sepsis-induced group showed a significantly elevated malondialdehyde (MDA) level in comparison to the sham group (p < 0.01). Nevertheless, the groups that received AgNPs experienced a decrease in MDA levels and an increase in glutathione and superoxide dismutases levels (p < 0.01). Additionally, the rats treated with AgNPs exhibited a reduction in the IL-1β mRNA expression levels (p < 0.01).
Przeciwdziałanie marginalizacji osób starszych w pastoralnej posłudze Kościoła
Authors: Dziedzic Jan 
Published: October 2024

Niniejszy artykuł przedstawia współczesne przejawy marginalizacji seniorów oraz poszukuje sposobów przeciwdziałania tym negatywnym zjawiskom mającym dzisiaj miejsce. W naszej refleksji uwzględnimy tylko aspekt pastoralny, dlatego w oparciu o nauczanie Kościoła przedstawimy ocenę tego zjawiska, a następnie przybliżymy konkretne propozycje przeciwdziałania wykluczeniu przez starość w działalności duszpasterskiej. Marginalizacja seniorów wynika ze współczesnej kultury, która preferuje młodość, atrakcyjność i piękno. Powoduje ją także kryzys rodziny, zwłaszcza brak rodzin wielopokoleniowych, co sprawia, że osoby starsze zamieszkuję samotnie, są rzadko odwiedzane i niekiedy umieszczane przez bliskich w instytucjach opiekuńczych. Na wykluczenie społeczne wpływa też przejście na emeryturę i utrata dawnego statusu społecznego i materialnego oraz utrata zdrowia. Marginalizacji seniorów przeciwstawia się Kościół, który wzywa do szacunku wobec osób starszych. Czyni to, ukazując absolutną wartość osoby ludzkiej w każdej bez wyjątku fazie życia. W przeciwdziałaniu marginalizacji społecznej osób w podeszłym wieku pomagają różne formy duszpasterstwa. Seniorzy jeszcze aktywni mogą się włączyć do różnych wspólnot parafialnych, grup modlitewnych, klubów seniora, wolontariat, czy Uniwersytet Trzeciego Wieku. Troską duszpasterską objęci są także seniorzy w sytuacji choroby i cierpienia. Są to odwiedziny w domu i szpitalu, posługa sakramentalna oraz wsparcie duchowe.
JOGOS INDÍGENAS E A LEI 11.645/2008: POSSIBILIDADES PARA UM CURRÍCULO INTERCULTURAL
Authors: Moraes da Silva Inayara , Rabelo Jairzinho , Dorigon Juli Cristina 
Published: October 2024

A proposta que move este estudo baseia-se em uma pesquisa bibliográfica que visa analisar como as atividades realizadas nos Jogos Indígenas podem ser utilizadas no currículo, considerando as memórias e a cultura dos povos originários, correlacionando-as às exigências da Lei 11.645/2008. Pensar os Jogos Indígenas nessa perspectiva é uma resposta que a escola precisa dar às inúmeras culturas presentes na sociedade, nos papéis que os professores podem exercer no desenvolvimento do currículo, especificamente quando se quer atender a diversidade e ainda nas potencialidades da educação intercultural no sentido da renovação de um currículo que concretize o princípio de escola para todos. Buscaremos um diálogo com os principais autores sobre interculturalidade, identidade, conceitos sobre o currículo inter e multicultural, e sua conexão com a diversidade, utilizando os Jogos Indígenas para analisar formas diversas de conhecimentos construídos nesses eventos, de maneira que seja possível aproximá-los das práticas docentes e propor a atividade intercultural na escola, em conformidade com a legislação. Nessa direção, Grando, Xavante e Campos (2015) trazem em seu trabalho um importante estudo sobre jogos e brincadeiras indígenas presentes na memória de adultos e idosos de 18 etnias indígenas. Por seu turno, Cuyabano (2010) amplia a discussão ao contextualizar as relações históricas entre os povos originários e a sociedade não indígena, a partir do diálogo com as experiências vivenciadas nos jogos e a literatura atual. Na mesma direção, o autor Silva (2014) em seu livro “Identidade e diferença: a perspectiva dos Estudos culturais” apresenta a importância do conceito de identidade e as relações entre cultura, identidade e diferença. Por seu turno, direção Brighenti (2022) apresenta a relação entre a Lei 11.445, educação intercultural que pode ser vivenciada na escola. Em outra direção, os autores Dorrico (2021) e Delmondez e Pulino (2014), discutem a relação entre educação indígena e educação escolar indígena, entre outros autores com importante contribuição sobre o currículo intercultural neste estudo. Nessa perspectiva, situamos este trabalho, que busca uma educação democrática, justa e plural, com especial relevância no momento atual marcado por perspectivas conservadoras e reacionárias, orientado pela perspectiva decolonial e sua inter-relação com a educação intercultural crítica.
Museu Virtual na Amazônia
Authors: Nascimento Cleane , Machado Ananda , Maroti Paulo Sérgio 
Published: October 2024

A presente proposta propõe discutir o potencial da construção de um Museu Virtual com Artes de Mulheres Indígenas em Roraima e seu uso pedagógico, visando contribuir na implementação da Lei nº 11.645. A partir do uso das Tecnologias da Informação e Comunicação (TIC), recurso que será disponibilizado gratuitamente na web, propiciaremos a divulgação e a democratização das artes e das histórias de mulheres indígenas em Roraima. E assim o discente, na interação com o Museu, será um sujeito ativo, reflexivo e crítico. A metodologia utilizada consiste na pesquisa qualitativa, com resultados que permitem a vivência de experiências inovadoras na proposição de um espaço de protagonismo das mulheres indígenas e dos discentes no processo de ensino/aprendizagem.
Enhancing anatomy comprehension through competency-specific formative assessments: A study on the effectiveness of pre and post lecture multiple-choice questions in CBME
Authors: Rajasekhar SSSN  , Nagarajan Sujithaa 
Published: October 2024

Modern medical education was required to include clear, tailored and regular formative assessments, especially for Millennials. Competency-Based Medical Education (CBME) emphasized the objective assessment of anatomical competencies. Question-answer and viva-voce tests were considered subjective and resource-intensive. This research was conducted to examine how competency-specific formative assessments using multiple-choice questions and photos before and after competency-based medical lectures improved anatomy comprehension.: The research involved 150 first-year MBBS students who were enrolled in online anatomy courses. Competency-specific, picture-based, clinical scenario-based and multiple-choice pre-questionnaires were distributed. The questions were reviewed and attempted by students before attending the theory classes. Lecture classes were conducted according to the curriculum and competencies of the National Medical Council. After the lecture, the questions and answers were reviewed and a feedback questionnaire was administered. The feedback survey included Likert scale responses and open-ended questions to gauge students' opinions on the teaching and learning methodology.: It was observed that the method was effective, stimulating curiosity, motivation and engagement. Participants expressed that the approach facilitated memorization, imparted clinical knowledge and reinforced theory. Clinical scenario-based multiple-choice questions were found to enhance memory, spark interest and improve understanding of anatomy's clinical relevance. Students believed that this method would benefit them in university exams. Overall, 89.7% of participants found the methods highly satisfactory, 50% satisfactory and 10.3% unsatisfactory.: Competency-specific formative assessments using multiple-choice questions and photos before and after lectures were found to improve anatomy knowledge. The strategy was found to promote engagement, memory and clinical understanding, reinforcing anatomical concepts. The results of this study suggested that competency-specific formative assessments added value to the current CBME-based medical education by increasing learning and practical application.
Levantamento das síndromes Pós-Covid em uma unidade de saúde da região norte de Palmas - TO / DATA SURVEY OF POST-COVID SYNDROMES IN A HEALTH UNIT FROM THE NORTH REGION OF PALMAS – TO
Authors: REIS DE OLIVEIRA CAMAROLLI ALICE KELLY , Malheiros Alves Marta Maria , DE SOUSA RÊIS MÁRLLON 
Published: October 2024

Introdução: A Covid-19 pode trazer consequências em longo prazo, uma vez que afeta diversos órgãos, resultando em processo de recuperação mais prolongado e por vezes, complexo. A síndrome pós-Covid-19 ou Covid Longo, como também pode ser chamada, nada mais é do que os sintomas persistentes ou disfunção após o período agudo da infecção pelo SARS-CoV2.
Objetivo: Analisar os sintomas persistentes após a infecção pela Covid-19 em pacientes assistidos por uma Unidade de Saúde da região norte de Palmas-TO.
Métodos: Estudo quantitativo, transversal, de objetivo descritivo, onde foram analisadas as respostas dos participantes, que foram obtidas através da aplicação de questionário físico ou online.
Resultados: As comorbidades pré-relatadas estão diretamente correlacionadas com o surgimento da síndrome pós-Covid nessa população. Todos os sintomas foram relatados após o período agudo ou ainda persistiram desde a fase aguda até quatro semanas após.
Conclusões: Apesar das limitações, nossos resultados demonstram que há um risco considerável de sequelas na população. Destacamos ainda o quão amplo são as manifestações da síndrome pós-Covid, seja ela após infecção aguda leve, moderada ou grave.
Palavras-chave:
Infecções por Coronavírus; Epidemiologia; Vírus da SARS; Pandemias; Complicações.

ABSTRACT
Introduction: The Covid-19 infection can have long-term consequences, since it affects several organs, resulting in a longer and complex recovery process. Post-Covid-19 syndrome or Long Covid, as it has been called, is nothing more than persistent symptoms or resulting dysfunction after the acute period of SARS-CoV2 infection.
Objective: Analyze persistent symptoms after infection with Covid-19 in patients assisted by a Health Unit from the northern region of Palmas-TO.
Methods: Quantitative and cross-sectional study, with a descriptive objective, where the answer of the participants were analyzed. The answers were obtained through the application of a physical or online questionnaire.
Results: Pre-reported comorbidities are directly correlated with the onset of post-Covid syndrome in this population. All symptoms were reported after the acute period or still persisted from the acute phase up to four weeks later.
Conclusion: Despite the limitations, our results demonstrate that there is a considerable risk of sequelae in the population. We also highlight how broad the manifestations of post-Covid syndrome are, be it after mild, moderate or severe acute infection.
Keywords:
Coronavirus Infections; Epidemiology; SARS Virus; Pandemics; Complications.
Ethical and regulatory issues and factors around 3D printing in Orthopaedic surgery: a scoping review Protocol
Authors: Akpa-Inyang Francis , Rocher Antoine , Marais Leonard 
Published: October 2024

Abstract

Background: The use of three-dimensional (3D) printing technology in orthopaedic surgery has become increasingly prevalent, offering numerous benefits such as improved surgical planning, personalized implants, and enhanced patient outcomes. However, along with the rapid adoption of this technology, ethical and regulatory considerations have emerged. This scoping review protocol aims to systematically evaluate the existing literature on ethical and regulatory issues related to 3D printing in orthopaedic surgery.
Method and Analysis:The protocol follows a rigorous methodology, including a comprehensive search of electronic databases such as PubMed/MEDLINE, EBSCOhost (academic search complete, CINAHL with full text) Scopus, Google Scholar, and web of science, using predefined search terms and inclusion criteria. The search will include studies published from 2011 to 2023 to ensure the most up-to-date information is captured. The scoping review will employ a systematic approach to study selection, data extraction, and synthesis of findings. The identified studies will undergo critical appraisal to assess their quality and relevance to the research question. Data synthesis will involve thematic analysis and the generation of a comprehensive overview of the ethical and regulatory issues associated with 3D printing in orthopaedic surgery.
Discussion: The findings of this scoping review will contribute to the existing body of knowledge by providing a comprehensive and systematic evaluation of the ethical and regulatory landscape surrounding 3D printing in orthopaedic surgery. It will identify gaps in the literature, highlight areas of concern, and offer recommendations for future research and policy development.
Ultimately, the aim of this scoping review is to provide healthcare professionals, researchers, and policymakers with a comprehensive understanding of the ethical and regulatory challenges associated with the use of 3D printing in orthopaedic surgery. This knowledge will facilitate the development of guidelines and best practices to ensure the responsible and ethical integration of 3D printing technology in orthopaedic surgical practice.