bluuebunny/crossref_metadata_2025_split huggingface dataset:
No relationship between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies
Authors: Li Xiao-na , Wang Bao-jie , Yao Jun 
Published: July 2019

Abstract
Background

Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human dopamine receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia.

Methods

The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia.

Results

We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There were no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fix effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT and HHRR studies, except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies.

Conclusions

Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.
Curricular Integration of the Pharmacist’s Patient Care Process (PPCP)
Authors: Chamoun Nibal , Nasser soumana C. , Kuyumjian Yara M. , Dimassi Hani 
Published: July 2019

Abstract
Background

The Accreditation Council for Pharmacy Education (ACPE) standard 10 specifies the need to prepare students to provide patient-centered collaborative care through both the didactic and experiential pharmacy curriculum. The aim of this study is to assess the impact of a newly introduced PPCP based laboratory course on students’ perception of their preparedness to apply PPCP steps in introductory pharmacy practice experiences (IPPEs).

Methods

In spring of 2017, PPCP was introduced into the Pharmaceutical Care and Dispensing Laboratory course. Students’ self-perception of preparedness to apply PPCP was assessed via a survey composed of questions related to PPCP skillsets. The pre-PPCP laboratory cohort (control group) took the survey after the completion of their experiential rotations. The PPCP laboratory cohort (intervention group) took the same survey prior to taking the course, at the end of the course and then following the completion of their IPPEs. The Pearson’s and McNemar Chi-square tests were used for statistical analysis.

Results

The findings indicate that the PPCP based laboratory significantly improved students’ perception of their preparedness to apply a standardized pharmacist care process to verify prescriptions, to collect relevant patient information, and to develop an individual patient-centered care plans. This significant impact of the PPCP based laboratory course on students’ perception was maintained through the following year when assessed after IPPEs.

Conclusion

Introduction of the PPCP model within a dispensing laboratory course, prior to students’ IPPEs, develops students’ perception of preparedness. Incorporating PPCP via active learning and simulation narrows the gap between the didactic and experiential curriculum by establishing a bridge between understanding the concept of PPCP and readiness for applying it in practice experiences.
Implementation Study of a 5-component Pediatric Early Warning System (PEWS) in an Emergency Department in British Columbia, Canada, to inform provincial scale up
Authors: McElroy Theresa A , Swartz Erik N. , Hassani Kasra , Waibel Sina , Tuff Yasmin , Marshall Catherine , Chan Richard , Wensley David , O'Donnell Maureen 
Published: August 2019

Abstract
Background: The rapid identification of deterioration in the pediatric population is complex, particularly in the emergency department (ED). A comprehensive multi-faceted Pediatric Early Warning System (PEWS) might maximize early recognition of clinical deterioration and provide a structured process for the reassessment and escalation of care. The objective of the study was to evaluate the implementation fidelity, effectiveness and utility of a 5-component PEWS implemented in the ED of an urban public general hospital in British Columbia, Canada, to guide provincial scale up.
Methods: We used a before-and-after design to evaluate the implementation fidelity, effectiveness and utility of a 5-component PEWS (pediatric assessment flowsheet, PEWS score, situational awareness, escalation aid and communication framework). Sources of data included patient charts, surveys of direct care staff, and key-informant interviews. Data were analyzed using mixed-methods approaches.
Results: The majority of charts had documented PEWS scores at triage (80%) and first bedside assessment (81.2%) indicating that the intervention was implemented with high fidelity. The intervention was effective in increasing vital signs documentation, both at first beside assessment (84% increase) and throughout the ED stay (>100% increase), in improving staff’s self-perceived knowledge and confidence in providing pediatric care, and self-reported communication between staff. Satisfaction levels were high with the PEWS scoring system, flowsheet, escalation aid, and to a lesser extent with the situational awareness tool and communication framework. Reasons for dissatisfaction included increased paperwork and incidence of false-positives. Overall, the majority of providers indicated that implementation of the PEWS system and completing a PEWS score at triage alongside the Canadian Triage and Acuity Scale (CTAS) added value to pediatric care in the ED. Results also suggest that the intervention is aligned with current practice in the ED.
ESTRATÃ‰GIA DE SAÃšDE DA FAMÃLIA E ATENÃ‡ÃƒO PRIMÃRIA A SAÃšDE DE QUEM ESTÃ TRABALHANDO
Authors: Milagres Clarice Santana , Lodi Jucilene Casati , Cardoso Juliana Aparecida Fialho 
Published: July 2019

Este trabalho enfoca as mudanÃ§as ocorridas na implementaÃ§Ã£o das polÃ­ticas de saÃºde do atual sistema apresentado no Brasil, o SUS, bem como a atenÃ§Ã£o que Ã© dada Ã queles trabalhadores que estÃ£o em seus processos de trabalho, quando o mesmo passa a maior parte do tempo Ãºtil diÃ¡rio em um expediente de trabalho contÃ­nuo. Objetivo: avaliar o atendimento prestado pela Unidade de SaÃºde da FamÃ­lia (USF) Ã populaÃ§Ã£o que trabalha em uma empresa da cidade de VitÃ³ria â€“ ES. Materiais e MÃ©todos: trata-se de uma pesquisa descritiva exploratÃ³ria, com abordagem qualiquantitativa, realizada numa empresa de mÃ©dio porte na cidade de VitÃ³ria. Para a anÃ¡lise descritiva, foram utilizadas as variÃ¡veis: utilizaÃ§Ã£o dos serviÃ§os de saÃºde, presenÃ§a de EstratÃ©gia de SaÃºde da FamÃ­lia no bairro de moradia, conhecimento do seu funcionamento, dificuldade de acesso. Resultados: dos participantes da pesquisa, 79,6% nÃ£o sÃ£o atendidos pela estratÃ©gia, destes 53,2% nÃ£o sabem da existÃªncia da unidade de saÃºde da famÃ­lia e 46,8% jÃ¡ ouviram falar, mas nÃ£o sabem como funciona, porque o horÃ¡rio de atendimento da unidade coincide com o seu horÃ¡rio de trabalho, dificultando o acesso. JÃ¡ 20,4% utilizam a unidade esporadicamente por possuÃ­rem plano de saÃºde. Quanto ao grau de satisfaÃ§Ã£o, 49% estÃ£o satisfeitos com o atendimento recebido na unidade e 35% estÃ£o insatisfeitos. ConclusÃ£o: hÃ¡ necessidade de se frisar a importÃ¢ncia de informaÃ§Ãµes e educaÃ§Ã£o em saÃºde Ã populaÃ§Ã£o e melhoria na oferta de serviÃ§os do mesmo. Uma grande preocupaÃ§Ã£o nos achados da pesquisa foi a identificaÃ§Ã£o de pessoas que ainda desconhecem a existÃªncia da unidade de saÃºde da famÃ­lia, procurando outro tipo de assistÃªncia que supra suas necessidades de saÃºde e que ofereÃ§a atendimento apÃ³s o horÃ¡rio comercial.
EDUCAÃ‡ÃƒO AMBIENTAL COMO SUPORTE PARA A CONSCIENTIZAÃ‡ÃƒO DE CRIANÃ‡AS SOBRE A COLETA SELETIVA: UM EXEMPLO PRÃTICO EM UMA ESCOLA DE MUTUM, MG.
Authors: BrandÃ£o Jeane de FÃ¡tima Cunha , Barbosa Sara CÃ¢ndida , BrandÃ£o Isac Jonatas 
Published: July 2019

O trabalho teve como objetivo analisar a importÃ¢ncia da EducaÃ§Ã£o ambiental na conscientizaÃ§Ã£o de crianÃ§as do terceiro ano do ensino fundamental sobre a coleta seletiva. A pesquisa foi realizada em uma escola de Mutum, MG para uma amostra de 40 alunos. Aplicou-se um jogo sobre coleta seletiva para crianÃ§as com idades de oito (grupo um) e nove anos (grupo dois), em dois momentos distintos. Para realizaÃ§Ã£o do jogo, foram distribuÃ­das cinco lixeiras com cores diferentes e 50 figuras de resÃ­duos no pÃ¡tio da escola. Logo apÃ³s, as crianÃ§as foram orientadas a descartar os resÃ­duos nas lixeiras. Na primeira aplicaÃ§Ã£o do jogo, os alunos tiveram apenas uma orientaÃ§Ã£o bÃ¡sica sobre como descartar os resÃ­duos nas lixeiras, obedecendo Ã s cores da coleta seletiva. ApÃ³s a conscientizaÃ§Ã£o dos alunos com textos informativos sobre coleta seletiva, o jogo foi reaplicado. Os alunos do grupo dois (9 anos) obtiveram um maior Ã­ndice de acerto nas duas aplicaÃ§Ãµes do jogo, comparando-se com o grupo um (8 anos). Mas, ambos os grupos aumentaram significativamente o Ã­ndice de acerto na reaplicaÃ§Ã£o, o que mostra a importÃ¢ncia da educaÃ§Ã£o ambiental na escola.
ACESSIBILIDADE E RESOLUTIVIDADE DOS SERVIÃ‡OS DE SAÃšDE: PERSPECTIVAS DE USUÃRIOS E PROFISSIONAIS.
Authors: Santos Tatiana Vasques Camelo dos , Penna ClÃ¡udia Maria de Mattos 
Published: July 2019

Estudo de caso qualitativo fundamentado na Sociologia Compreensiva do Cotidiano, realizado em 3 unidades de ESF e no UPA no municÃ­pio de ManhuaÃ§u â€“ MG, com o objetivo de compreender, na percepÃ§Ã£o de usuÃ¡rios e profissionais, a resolutividade das aÃ§Ãµes desenvolvidas no Ã¢mbito dos serviÃ§os de saÃºde. Para tanto, foram realizadas entrevistas com 20 profissionais e 17 usuÃ¡rios. Os dados foram submetidos Ã anÃ¡lise de conteÃºdo. As questÃµes de baixa resolutividade estÃ£o ligadas Ã acessibilidade organizacional. JÃ¡ na percepÃ§Ã£o dos usuÃ¡rios, o serviÃ§o resolutivo Ã© o produto do encontro entre as demandas por ele sentidas, a oferta de serviÃ§os e o tempo gasto para que sua necessidade seja atendida. PorÃ©m, se a demanda apresentada pelo usuÃ¡rio nÃ£o encontrar a oferta adequada de serviÃ§os (tecnologias, pacote de serviÃ§os demorados ou inoportunos), as aÃ§Ãµes nÃ£o o serÃ£o.
PREVALÃŠNCIA DE CANDIDÃASE VULVOVAGINAL EM MULHERES DA REGIÃƒO DA BAIXADA FLUMINENSE, ESTADO DO RIO DE JANEIRO, BRASIL
Authors: Norberg Antonio Neres , Santa Helena AluÃ­zio Antonio de , Madeira-Oliveira JosÃ© Tadeu , Sanches Fabiano Guerra , Ribeiro Paulo CÃ©sar , Machado Alex Nagem , Freire Nicolau MauÃ©s Serra 
Published: July 2019

Objetivo: Investigar a prevalÃªncia de infecÃ§Ã£o por espÃ©cies do gÃªnero Candida em mulheres com sintomas e sinais clÃ­nicos de vulvovaginites e encaminhar as positivas para o tratamento especÃ­fico. Pacientes e mÃ©todos: Entre janeiro de 2010 e dezembro de 2012, foram coletadas amostras cÃ©rvico-vaginais de 480 mulheres com o auxÃ­lio de suabes. Foram semeadas em meio de cultura Sabouraud-Dextrose-Ãgar e incubadas a temperatura de 37oC por atÃ© cinco dias. As amostras com crescimento fÃºngico foram identificadas por caracteres morfotintoriais e provas bioquÃ­micas pelo sistema BioMerieux-Vitek. Resultados: Foram identificadas infecÃ§Ãµes por trÃªs espÃ©cies de fungos: Candida albicans (89.04%), C. krusei (4,11%) e C. tropicalis (6,85%). Houve dominÃ¢ncia significativa de C. albicans em todas as quatro classes de idade das mulheres; entre estas, a classe entre 21 e 30 anos foi a de maior dominÃ¢ncia para o nÃºmero de casos. ConclusÃµes: A candidÃ­ase vulvovaginal diagnosticada em mulheres da Baixada Fluminense tem dominÃ¢ncia de Candida albicans, com intercorrÃªncia de C. tropicalis e C. krusei. Ã‰ prioritÃ¡rio recomendar, Ã s mulheres, acompanhamentos periÃ³dicos com ginecologista e realizar exames ginecolÃ³gicos de secreÃ§Ã£o vaginal para o diagnÃ³stico precoce da candidose..
Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Advanced Thyroid Cancer
Authors: Vaccher Emanuela , Schioppa Ornella , Martellotta Ferdinando , Fornasier Giulia , Giacomin Elisa , Re Francesco Lo , Baldo Paolo , Corona Giuseppe , Gobitti Carlo 
Published: August 2019

Background:Thyroid cancer is the most common endocrine neoplasia and represents approximately 1.5% to 2.1% of all cancers diagnosed annually worldwide. Iodine Refractory Differentiated Thyroid Carcinoma (RR-DTC) and advanced/metastatic medullary thyroid carcinoma are relatively uncommon yet prognostically significant thyroid cancers. Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers, including thyroid cancer. Many Multi-Kinase Inhibitors (MKIs) which are now FDA-/EMA approved for thyroid cancer have shown clinical benefit in patients with advanced cancer. Treatmentrelated toxicities occur frequently with these drugs and can be severe or life-threatening.Objective:This review summarizes the role of targeted therapy with MKIs in the management of RRDTC and advanced/metastatic MTC patients, focusing on side-effect profiles of these drugs, with a presentation of several recent patents published in this field.Methods:We review the scientific literature on advanced thyroid cancer and analyze the International Pharmacovigilance database (FAERS, Eudravigilance, and WHO Vigibase) for adverse drug reactions.Results:This systematic analysis highlights the difference in the safety profile of the recent drugs used in the treatment of advanced thyroid cancer and the recent discoveries for diagnosis or treatment of the thyroid cancer.Conclusion:It is essential to investigate the safety profile of recent anticancer drugs for advanced thyroid cancer to allow health professionals to make the best choice for each patient by conducting risk/benefit assessment.
Mathematical model of the formation and development of wave-shaped rail wear when an electric locomotive operates in the traction mode in tangent sections of the track
Authors: Kogan A. Ya. 
Published: July 2019

The problem of wave-shaped rail wear is highly relevant for rail transport. The paper presents a mathematical model of the formation and development of wave-shaped rail wear. The task of estimating vertical wear of the rail head under the axles of electric locomotives passing in the traction mode is considered. A technique has been developed that allows building chain of calculations that determine the formation and development of a wave-shaped rail head wear. A specific calculation example is given, illustrating the process of propagation of a wave-shaped wear from the source of its formation in the direction of train motion. An example of the calculation allows drawing the following conclusions:1. Wave-shaped wear primarily occurs when the shock interaction of the wheel of an electric locomotive moving in the traction mode and a rail thread having imperfections of the rolling surface. Such imperfections, among others, may be a joint with a significant gap or a “step down” in the direction of the locomotive, as well as a welded joint with defect 46.3-4.2. Wavelength of the wave-shaped rail wear, its configuration and amplitude of the fundamental tone are determined mainly by joint oscillations of the wheel-motor unit of the locomotive and the track infrastructure in the field of high-frequency oscillations (120 – 180 Hz).3. Multivariate calculations showed that in steady state, the distribution speed of wave-shaped rail wear in the direction of train motion (as a function of the number of axles of electric locomotives passed in traction mode) is directly proportional to the vertical load at the wheel and rail contact in the slip zone 0≤Q≤F/(2nψk), is inversely proportional to wear resistance C and significantly depends on the parameters of the undercarriage of the electric train and the track superstructure.
Validation of an mHealth App for Depression Screening and Monitoring (Psychologist in a Pocket): Correlational Study and Concurrence Analysis
Authors: Ramos Roann Munoz , Cheng Paula Glenda Ferrer , Jonas Stephan Michael 
Published: July 2019

Background
Mobile health (mHealth) is a fast-growing professional sector. As of 2016, there were more than 259,000 mHealth apps available internationally. Although mHealth apps are growing in acceptance, relatively little attention and limited efforts have been invested to establish their scientific integrity through statistical validation. This paper presents the external validation of Psychologist in a Pocket (PiaP), an Android-based mental mHealth app which supports traditional approaches in depression screening and monitoring through the analysis of electronic text inputs in communication apps.

Objective
The main objectives of the study were (1) to externally validate the construct of the depression lexicon of PiaP with standardized psychological paper-and-pencil tools and (2) to determine the comparability of PiaP, a new depression measure, with a psychological gold standard in identifying depression.

Methods
College participants downloaded PiaP for a 2-week administration. Afterward, they were asked to complete 4 psychological depression instruments. Furthermore, 1-week and 2-week PiaP total scores (PTS) were correlated with (1) Beck Depression Index (BDI)-II and Center for Epidemiological Studies–Depression (CES-D) Scale for congruent construct validation, (2) Affect Balance Scale (ABS)–Negative Affect for convergent construct validation, and (3) Satisfaction With Life Scale (SWLS) and ABS–Positive Affect for divergent construct validation. In addition, concordance analysis between PiaP and BDI-II was performed.

Results
On the basis of the Pearson product-moment correlation, significant positive correlations exist between (1) 1-week PTS and CES-D Scale, (2) 2-week PTS and BDI-II, and (3) PiaP 2-week PTS and SWLS. Concordance analysis (Bland-Altman plot and analysis) suggested that PiaP’s approach to depression screening is comparable with the gold standard (BDI-II).

Conclusions
The evaluation of mental health has historically relied on subjective measurements. With the integration of novel approaches using mobile technology (and, by extension, mHealth apps) in mental health care, the validation process becomes more compelling to ensure their accuracy and credibility. This study suggests that PiaP’s approach to depression screening by analyzing electronic data is comparable with traditional and well-established depression instruments and can be used to augment the process of measuring depression symptoms.
Evaluation of a Technology-Based Peer-Support Intervention Program for Preventing Postnatal Depression (Part 1): Randomized Controlled Trial
Authors: Shorey Shefaly , Chee Cornelia Yin Ing , Ng Esperanza Debby , Lau Ying , Dennis Cindy-Lee , Chan Yiong Huak 
Published: July 2019

Background
The frenzy of postbirth events often takes a toll on mothers’ mental well-being, leaving them susceptible to postpartum psychological disorders such as postnatal depression (PND). Social support has been found to be effective in restoring the emotional well-being of new mothers. Therefore, mothers need to be supported during the crucial postpartum period to buffer the negative after effects of childbirth and to promote healthier maternal well-being.

Objective
This study aimed to evaluate the effectiveness of a technology-based peer-support intervention program (PIP) on maternal outcomes during the early postpartum period.

Methods
A randomized, parallel-armed controlled trial was conducted. The study recruited 138 mothers (69 in intervention group, 69 in control group) at risk of PND from a tertiary hospital in Singapore. To support these mothers, 20 peer volunteers were recruited by word of mouth and trained by a psychiatrist in social support skills before the intervention commenced. The 4-week–long intervention included a weekly follow-up with a peer volunteer through phone calls or text messages. The intervention group received peer support in addition to the standard care offered by the hospital. The control group only received postnatal standard care. Maternal outcomes (PND, postnatal anxiety [PNA], loneliness, and perceived social support) were measured with reliable and valid instruments. Data were collected immediately postpartum, at 1 month postpartum and at 3 months postpartum. The general linear model was used to compare the groups for postpartum percentage changes in the outcome variables at first and third months, and the linear mixed model was used to compare the trend over the study period.

Results
There was a statistically significant difference in Edinburgh Postnatal Depression Scale scores (d=–2.11; 95% CI −4.0 to −0.3; P=.03) between the intervention and control groups at 3 months postpartum after adjusting for covariates. The intervention group had a significant change over time compared with the control group.

Conclusions
The technology-based PIP was found to be effective in reducing the risk of PND among new mothers and showed a generally positive trend in reducing PNA and loneliness and increasing perceived social support. This study highlights the importance of training paraprofessionals to provide needed support for new mothers postpartum. A further long-term evaluation of the PIP on maternal and family outcomes and its cost-effectiveness is needed to inform clinical practices.

Trial Registration
ISRCTN Registry ISRCTN14864807; https://www.isrctn.com/ISRCTN14864807

International Registered Report Identifier (IRRID)
RR2-10.2196/resprot.9416