bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ground motion simulation and validation of the 2008 Chino Hills earthquake in scattering media
Authors: Savran W H , Olsen K B 
Published: September 2019

SUMMARYWe simulate 0–2.5 Hz deterministic wave propagation in 3-D velocity models for the 2008 Chino Hills, CA, earthquake using a finite-fault source model and frequency-dependent anelastic attenuation. Small-scale heterogeneities are modeled as 3-D random fields defined using an elliptically anisotropic von Kármán autocorrelation function with its parameters constrained using Los Angeles basin borehole data. We superimpose the heterogeneity models on a leading deterministic community velocity model (CVM) of southern California. We find that models of velocity and density perturbations can have significant effects on the wavefield at frequencies as low as 0.5 Hz, with ensemble median values of various ground motion metrics varying up to ±50 per cent compared to those computed using the deterministic CVM only. In addition, we show that frequency-independent values of the shear-wave quality factor (Qs0) parametrized as Qs0 = 150Vs (Vs in km s–1) provides the best agreement with data when assuming the published moment magnitude (Mw) of 5.4 (M0 = 1.6 × 1017 Nm) for the finite-fault source model. This model for Qs0 trades off with Qs0 = 100Vs assuming Mw = 5.5 (M0 = 2.2 × 1017 Nm), which represents an upper bound of the Mw estimates for this event. We find the addition of small-scale heterogeneities provides limited overall improvement to the misfit between simulations and data for the considered ground motion metrics, because the primary sources of misfit originate from the deterministic CVM and/or the finite-fault source description.
High-frequency seismic wave modelling of the deep Earth based on hybrid methods and spectral-element simulations: a conceptual study
Authors: Lin Chuangxin , Monteiller Vadim , Wang Kai , Liu Tianshi , Tong Ping , Liu Qinya 
Published: September 2019

SUMMARYOver the past few decades, seismic studies have revealed complex structural anomalies in the Earth’s deep interior at various scales, such as large low-shear-velocity provinces (LLSVPs) and ultra-low velocity zones (ULVZs) in the lowermost mantle, and small-scale scatterers in the mid-mantle. These structures which are critical for better understanding of the geodynamics and evolution of the deep Earth, need to be further resolved by high-resolution imaging techniques. The spectral-element method (SEM) can be used to accurately simulate seismic wave propagation in heterogeneous Earth models, and its application in full-waveform inversion (FWI) provides a promising high-resolution and high-fidelity imaging technique. But it can be computationally prohibitive when used to model small scale structures in the deep Earth based upon high-frequency seismic waves. The heavy computational cost can be circumvented by using hybrid methods, which restrict the main computation by SEM solver to only a small target region (e.g. above the CMB) encompassing possible 2-D/3-D anomalies, and apply efficient analytical or numerical methods to calculate the wavefield for 1-D background models. These forward modelling tools based on hybrid methods can be then used in the so-called ‘box tomography’ approach to resolve fine-structures in the deep Earth.In this study, we outline the theory of a hybrid method used to model small scale structures in the deep Earth and present its implementation based on SEM solvers in a three-step workflow. First, the wavefield generated by the source is computed for the 1-D background model with traction and velocity saved for the virtual boundary of the target region, which are then used as boundary inputs to simulate the wavefield in the target region based on absorbing boundary condition in SEM. In the final step, the total wavefield at receivers is reconstructed based upon the total wavefield on the virtual boundary computed in the previous step. As a proof-of-concept study, we demonstrate the workflow of the hybrid method based on a 2-D SEM solver. Examples of the hybrid method applied to a coupled fluid–solid model show that our workflow can accurately recover the scattered waves back to the surface. Furthermore, we benchmark the hybrid method on a realistic heterogeneous Earth model built from AK135-F and show how teleseismic scattered waves can be used to model deep Earth structures. By documenting the theory and SEM implementation of the hybrid method, our study lays the foundation for future two-way coupling of 3-D SEM solver with other efficient analytic or numerical 1-D solvers.
Galectin-8 in the onset of the immune response and inflammation
Authors: Tribulatti María V , Carabelli Julieta , Prato Cecilia A , Campetella Oscar 
Published: September 2019

AbstractGalectins (Gals), a family of mammalian lectins, have emerged as key regulators of the immune response, being implicated in several physiologic and pathologic conditions. Lately, there is increasing data regarding the participation of Galectin-8 (Gal-8) in both the adaptive and innate immune responses, as well as its high expression in inflammatory disorders. Here, we focus on the pro- and anti-inflammatory properties of Gal-8 and discuss the potential use of this lectin in order to shape the immune response, according to the context.
Is tuberculosis elimination a feasible goal in Colombia by 2050?
Authors: López Lucelly , Keynan Yoav , Marin Diana , Ríos-Hincapie Cielo Yaneth , Montes Fernando , Escudero-Atehortua Ana Cecilia , Rueda Zulma Vanessa 
Published: September 2019

Abstract
Colombia has an underreporting of 30% of the total cases, according to World Health Organization (WHO) estimations. In 2016, successful tuberculosis (TB) treatment rate was 70%, and the mortality rate ranged between 3.5% and 10%. In 2015, Colombia adopted and adapted the End TB strategy and set a target of 50% reduction in incidence and mortality by 2035 compared with 2015. The aims of this study were: To evaluate whether Colombia will be able to achieve the goals of TB incidence and mortality by 2050, using the current strategies; and whether the implementation of new screening, diagnosis and TB treatment strategies will allow to achieve those WHO targets. An ecological study was conducted using TB case-notification, successful treatment and mortality rates from the last 8 years (2009–17). System dynamics analysis was performed using simulated scenarios: (1) continuation with the same trends following the trajectory of the last 8 years (Status quo) and (2) modification of the targets between 2017 through 2050, assuming the implementation of multimodal strategies to increase the screening, to improve the early diagnosis and to improve the treatment adherence. Following the current strategies, it is projected that Colombia will not achieve the End TB strategy targets. Achieving the goal of TB incidence of 10/100 000 by 2050 will only be possible by implementing combined strategies for increasing screening of people with respiratory symptoms, improving access to rapid diagnostic tests and improving treatment adherence. Therefore, it is necessary to design and implement simultaneous strategies according to the population needs and resources, in order to stride towards the End TB targets.
Community-based men’s health promotion programs: eight lessons learnt and their caveats
Authors: Oliffe John L , Rossnagel Emma , Bottorff Joan L , Chambers Suzanne K , Caperchione Cristina , Rice Simon M 
Published: September 2019

Abstract
Long-standing commentaries about men’s reticence for accessing clinical medical services, along with the more recent recognition of men’s health inequities, has driven work in community-based men’s health promotion. Indeed, the 2000s have seen rapid growth in community-based programs targeting men, and across this expanse of innovative work, experiential and empirical insights afford some important lessons learnt, and caveats to guide existing and future efforts. The current article offers eight lessons learnt regarding the design, content, recruitment, delivery, evaluation and scaling of community-based men’s health promotion programs. Design lessons include the need to address social determinants of health and men’s health inequities, build activity-based programming, garner men’s permission and affirmation to shift masculine norms, and integrate content to advance men’s health literacy. Also detailed are lessons learnt about men-friendly spaces, recruitment and retention strategies, the need to incrementally execute program evaluations, and the limits for program sustainability and scaling. Drawing from diverse community-based programs to illustrate the lessons learnt, caveats are also detailed to contextualize and caution some aspects of the lessons that are shared. The express aim of discussing lessons learnt and their caveats, reflected in the purpose of the current article, is to guide existing and future work in the ever growing field of community-based men’s health promotion.
Hypoxic drive caused type 3 neovascularization in a preclinical model of exudative age-related macular degeneration
Authors: Zhang Lijuan , Cui Xuan , Han Yangjun , Park Karen Sophia , Gao Xiaohong , Zhang Ximei , Yuan Zhigang , Hu Yong , Hsu Chun-Wei , Li Xiaorong , Bassuk Alexander G , Mahajan Vinit B , Wang Nan-Kai , Tsang Stephen H 
Published: September 2019

Abstract
Hypoxia associated with the high metabolic demand of rods has been implicated in the pathology of age-related macular degeneration (AMD), the most common cause of adult blindness in the developed world. The majority of AMD-associated severe vision loss cases are due to exudative AMD, characterized by neovascularization. To further investigate the causes and histopathology of exudative AMD, we conditionally induced hypoxia in a novel preclinical AMD model (Pde6gcreERT2/+;Vhl−/−) by targeting Vhl and used multimodal imaging and immunohistochemistry to track the development of hypoxia-induced neovascularization. In addition to developing a preclinical model that phenocopies exudative AMD, our studies revealed that the photoreceptor hypoxic response initiates and drives type 3 neovascularization, mainly in the outer retina. Activation of the VHL-HIF1a-VEGF-EPO pathway in the adult retina led to long-term neovascularization, retinal hemorrhages and compromised retinal layers. Our novel preclinical model would accelerate the testing of therapies that use metabolomic approaches to ameliorate AMD.
Towards sustainable European seaweed value chains: a triple P perspective
Authors: van den Burg S W K , Dagevos H , Helmes R J K 
Published: September 2019

Abstract
Seaweeds are seen as important future feedstock for Europe, providing biomass for food, feed, and other applications. Seaweeds can contribute to a circular food system a protein transition and bio-based economy. Europe is a minor player in the world market dominated by the Asian producers and processors. According to the FAO, total production of aquatic plants (dominated by seaweed) was 30 million tonnes in 2016, with China (47.9%) and Indonesia (38, 7%) dominating production. This article discusses the challenges to seaweed production and use in Europe and formulates future directions for upscaling the European seaweed sector. From a People, Planet, Profit perspective, there is no need to focus on producing large volumes of seaweed per se. We need to focus on nature-inclusive production systems, producing the right amount of the right seaweeds, based on the carrying capacity of the European seas. The seaweed sector must avoid developing along the “old” economy’s way of cost leadership but develop along the way of the “new” circular economy. Seaweeds should not be seen as a new product “added” to the market but become an integral part of the European food system, being used for human consumption, feed and improving production processes.
Aerodynamic and structural optimization of wind turbine blade with static aeroelastic effects
Authors: Zhu Jie , Ni Xiaohui , Shen Xiaomei 
Published: September 2019

Abstract
With the increasing size of wind turbine blade, the aeroelastic analysis becomes an essential step in the blade design process. The scope of this paper is to investigate the static aeroelastic effects between the fluid–structure interaction and improve the blade performances. First, the rigid and flexible blades are used to analyze the effects of static aeroelasticity on the blade aerodynamic and structural performances through a blade element momentum model coupled with 3D finite element analysis model. Based on this, a multi-objective aerodynamic and structural optimization method is proposed aiming at increasing the annual energy production and reducing blade mass, key parameters of the blade are employed as design variables, and various design requirements including strain, deflection, vibration and buckling limits are considered as constraints. Finally, a commercial 1.5 MW wind turbine blade is applied as a case study, and the optimization results show great improvements for the aerodynamic and structural performances of the blade.
Moving frames and Noether’s finite difference conservation laws II
Authors: Mansfield E L , Rojo-Echeburúa A 
Published: September 2019

Abstract
In this second part of the paper, we consider finite difference Lagrangians that are invariant under linear and projective actions of $SL(2)$, and the linear equi-affine action that preserves area in the plane. We first find the generating invariants, and then use the results of the first part of the paper to write the Euler–Lagrange difference equations and Noether’s difference conservation laws for any invariant Lagrangian, in terms of the invariants and a difference moving frame. We then give the details of the final integration step, assuming the Euler Lagrange equations have been solved for the invariants. This last step relies on understanding the adjoint action of the Lie group on its Lie algebra. We also use methods to integrate Lie group invariant difference equations developed in Part I. Effectively, for all three actions, we show that solutions to the Euler–Lagrange equations, in terms of the original dependent variables, share a common structure for the whole set of Lagrangians invariant under each given group action, once the invariants are known as functions on the lattice.
Identification of Suvorexant in Blood Using LC–MS-MS: Important Considerations for Matrix Effects and Quantitative Interferences in Targeted Assays
Authors: Skillman Britni , Kerrigan Sarah 
Published: September 2019

Abstract
Suvorexant (Belsomra®) is a novel dual orexin receptor antagonist used for the treatment of insomnia. The prevalence of suvorexant in forensic samples is relatively unknown, which demonstrates the need for robust analytical assays for the detection of this sedative hypnotic in forensic toxicology laboratories. In this study, suvorexant was isolated from whole blood using a simple acidic/neutral liquid–liquid extraction followed by analysis by liquid chromatography tandem mass spectrometry (LC–MS/MS). Matrix effects were evaluated qualitatively and quantitatively using various extraction solvents, proprietary lipid clean-up devices and source conditions. The method was validated in terms of limit of detection, limit of quantitation, precision, bias, calibration model, carryover, matrix effects and drug interferences. Electrospray is a competitive ionization process whereby compounds in the droplet compete for a limited number of charged sites at the surface. As such, it is capacity-limited, and LC–MS-based techniques must be carefully evaluated to ensure that matrix effects or coeluting drugs do not impact quantitative assay performance. In this report, we describe efforts to ameliorate such effects in the absence of an isotopically labeled internal standard. Matrix effects are highly variable and heavily dependent on the physico-chemical properties of the substance. Although there is no universal solution to their resolution, conditions at the electrospray interface can mitigate these issues. Using this approach, the LC–MS/MS assay was fully validated and limits of detection and quantitation of 0.1 and 0.5 ng/mL suvorexant were achieved in blood.
Economic Mobility Under Pressure
Authors: Markussen Simen , Røed Knut 
Published: September 2019

AbstractBased on complete population data, with the exact same definitions of family class background and economic outcomes for a large number of birth cohorts, we examine post-war trends in intergenera-tional economic mobility in Norway. Standard summary statistics indicate stable or mildly declining rank–rank mobility for sons and sharply declining mobility for daughters. The most conspicuous trend in the mobility patterns is that men and women born into the lowest parts of the parental earnings distribution have fallen behind in terms of own earnings rank, as well as a number of other quality-of-life indicators. A considerable part of this development can be explained by changes in the class distribution of educational attainment and in its rising influence on earnings rank. We argue that although the educational revolution has diminished the role of inherited ability, it has enlarged the influence of the family as provider of a social learning environment.
Beliefs and Consumer Search in a Vertical Industry
Authors: Janssen Maarten , Shelegia Sandro 
Published: September 2019

Abstract
This paper studies vertical relations in a search market. As the wholesale arrangement between a manufacturer and its retailers is typically unobserved by consumers, their beliefs about who is to be blamed for a price deviation play a crucial role in determining wholesale and retail prices. The common assumption in the consumer search literature is that consumers exclusively blame an individual retailer for a price deviation. We show that in the vertical relations context, predictions based on this assumption are not robust in the sense that if consumers hold the upstream manufacturer at least partially responsible for the deviation, equilibrium predictions are qualitatively different. For robust beliefs, the vertical model can explain a variety of observations, such as retail price rigidity (or, alternatively, low cost pass-through), nonmonotonicity of retail prices in search costs, and (seemingly) collusive retail behavior. The model can be used to study a monopoly online platform that sells access to final consumers.
Constraints on high-J CO emission lines in z ∼ 6 quasars
Authors: Carniani S , Gallerani S , Vallini L , Pallottini A , Tazzari M , Ferrara A , Maiolino R , Cicone C , Feruglio C , Neri R , D’Odorico V , Wang R , Li J 
Published: September 2019

Abstract
We present Atacama Large Millimiter/submillimiter Array (ALMA) observations of eight highly excited CO (${\rm J_{\rm up}}$ >8) lines and continuum emission in two z ∼ 6 quasars: SDSS J231038.88+185519.7 (hereafter J2310), for which CO(8-7), CO(9-8), and CO(17-16) lines have been observed, and ULAS J131911.29+095951.4 (J1319), observed in the CO(14-13), CO(17-16) and CO(19-18) lines. The continuum emission of both quasars arises from a compact region (<0.9 kpc). By assuming a modified black-body law, we estimate dust masses of Log(Mdust/M⊙) = 8.75 ± 0.07 and Log(Mdust/M⊙) = 8.8 ± 0.2 and dust temperatures of Tdust = 76 ± 3 K and $T_{\rm dust}=66^{+15}_{-10}~{\rm K}$, respectively for J2310 and J1319. Only CO(8-7) and CO(9-8) in J2310 are detected, while 3σ upper limits on luminosities are reported for the other lines of both quasars. The CO line luminosities and upper limits measured in J2310 and J1319 are consistent with those observed in local AGN and starburst galaxies, and other z ∼ 6 quasars, except for SDSS J1148+5251 (J1148), the only quasar at z = 6.4 with a previous CO(17-16) line detection. By computing the CO SLEDs normalised to the CO(6-5) line and FIR luminosities for J2310, J1319, and J1149, we conclude that different gas heating mechanisms (X-ray radiation and/or shocks) may explain the different CO luminosities observed in these z ∼ 6 quasar. Future ${\rm J_{\rm up}}$ >8 CO observations will be crucial to understand the processes responsible for molecular gas excitation in luminous high-z quasars.
Long rotation period main-sequence stars from Kepler SAP light curves
Authors: Cui Kaiming , Liu Jifeng , Yang Shuhong , Gao Qing , Yang Huiqin , Soria Roberto , He Lin , Wang Song , Bai Yu , Yang Fan 
Published: September 2019

ABSTRACT
Stellar rotation plays a key role in stellar activity. The rotation period could be detected through light curve variations caused by star-spots. Kepler provides two types of light curves: one is the Pre-search Data Conditioning (PDC) light curves, and the other is the Simple Aperture Photometer (SAP) light curves. Compared with the PDC light curves, the SAP light curves keep the long-term trend, relatively suitable for searches of long-period signals. However, SAP data are inflicted by some artefacts such as quarterly rolls and instrumental errors, making it difficult to find the physical periods in the SAP light curves. We explore a systematic approach based on the light curve pre-processing, period detection, and candidate selection. We also develop a simulated light curve test to estimate our detection limits for the SAP-like LCs. After applying our method to the raw SAP light curves, we found more than 1000 main-sequence stars with periods longer than 30 d; 165 are newly discovered. Considering the potential flaw of the SAP, we also inspect the newly found objects with photometry methods, and most of our periodical signals are confirmed.
The g-mode spectrum of reactive neutron star cores
Authors: Andersson N , Pnigouras P 
Published: September 2019

Abstract
We discuss the impact of nuclear reactions on the spectrum of gravity g-modes of a mature neutron star, demonstrating the anticipated disappearance of these modes when the timescale associated with the oscillations is longer than that of nuclear reactions. This is the expected result, but different aspects of the demonstration may be relevant for related problems in neutron star astrophysics. In particular, we develop the framework required for an explicit implementation of finite-time nuclear reactions in neutron star oscillation problems and demonstrate how this formulation connects with the usual bulk viscosity prescription. We also discuss implications of the absence of very high order g-modes for problems of astrophysical relevance.
A dwarf disrupting – Andromeda XXVII and the North West Stream
Authors: Preston Janet , Collins Michelle L M , Ibata Rodrigo A , Tollerud Erik J , Rich R Michael , Bonaca Ana , McConnachie Alan W , Mackey Dougal , Lewis Geraint F , Martin Nicolas F , Peñarrubia Jorge , Chapman Scott C , Delorme Maxime 
Published: September 2019

ABSTRACT
We present a kinematic and spectroscopic analysis of 38 red giant branch stars, in seven fields, spanning the dwarf spheroidal galaxy Andromeda XXVII and the upper segment of the North West Stream. Both features are located in the outer halo of the Andromeda galaxy at a projected radius of 50–80 kpc, with the stream extending for ∼3° on the sky. Our data are obtained as part of the PAndAS survey and enables us to confirm that Andromeda XXVII’s heliocentric distance is 827 ± 47 kpc and spectroscopic metallicity is $-2.1^{+0.4}_{-0.5}$. We also re-derive Andromeda XXVII’s kinematic properties, measuring a systemic velocity = $-526.1^{+10.0}_{-11.0}$ km s−1 and a velocity dispersion that we find to be non-Gaussian but for which we derive a formal value of 27.0$^{+2.2}_{-3.9}$ km s−1. In the upper segment of the North West Stream we measure mean values for the metallicity = −1.8 ± 0.4, systemic velocity = −519.4 ± 4.0 km s−1, and velocity dispersion = 10.0 ± 4.0 km s−1. We also detect a velocity gradient of 1.7 ± 0.3 km s−1 kpc−1 on an infall trajectory towards M31. With a similar gradient, acting in the same direction, in the lower segment we suggest that the North West Stream is not a single structure. As the properties of the upper segment of the North West Stream and Andromeda XXVII are consistent within 90 per cent confidence limits, it is likely that the two are related and plausible that Andromeda XXVII is the progenitor of this stream.