bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond technique: The role of the multidimensional nature of energy accounting in shaping a better world
Authors: Magliacani Michela , Maione Gennaro , Toscano Valentina , Sica Daniela 
Published: November 2024

AbstractAdopting the “multidimensional nature of accounting” framework, this study aims to identify what factors hinder the adoption of energy accounting as a practice that shapes a better world. This paper wants to highlight that the social and moral dimensions of accounting cannot be taken for granted, since they can provide insights to the professional and research debate. The case study methodology is used to investigate energy accounting in the first Italian Renewable Energy Community (REC). Data were collected through open interview and focus group and processed with a qualitative content analysis. The findings highlight some specific technical, social, and moral factors that hinder the adoption of energy accounting in practice. Key propositions are provided to help organizations understand how to adopt energy accounting, going beyond its mere technical nature. Ways forward are proposed to cultivate more significant levels of aspiration to reduce the disconnection between accounting theory and practice.
Is dissection or prosection equal in dental anatomy education?
Authors: Karaca Bozdağ Zekiye , Çandır Buse Naz , Macunluoğlu Aslı Ceren , Gürses İlke Ali 
Published: November 2024

AbstractThis study aimed to investigate the learning outcomes and opinions about dissection and prosection methods among second‐year dental students. Twenty‐one dental students participated in the study. Two topographic subjects were selected from the head and neck region. Theoretical and practical pre‐tests for the first subject were presented. After the theoretical lecture, the students were randomly divided into dissection and prosection groups and a practical lesson was presented. A post‐test was then applied. On another day, the same steps were repeated for the second topographic topic, reversing the practice groups. A feedback questionnaire was supplied to the students at the end of the study. The questions in the first part of the feedback survey were scored using a 5‐point Likert scale, and the open‐ended questions in the second part were scored by creating a six‐step latent thematic analysis — main themes and sub‐themes. Post‐test scores were higher in both subjects (p < 0.001). While there was no difference between the pre‐ and post‐test student scores on practical questions in the first subject, the post‐test practical scores were higher in the second subject (p = 0.044). There was no significant difference between the dissection and prosection groups for either subject (p > 0.05). Most of the students (n = 18, 85.71%) stated that both methods were necessary for anatomy education. Some of them (n = 12, 57.41%) found prosection more useful and some (n = 5, 23.81%) found dissection more useful. In response to the answers to the open‐ended questions, four main themes were created and the results related to these main themes were collected in sub‐themes. This study shows that the preferred method of cadaveric education, whether dissection or prosection, has a positive effect on both students' emotions and learning outcomes. Institutions can use both methods in a balanced way when designing anatomy curricula in dental schools.
A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML
Authors: Sahib Noor Rashidha Binte Meera , Mohamed Jameelah Sheik , Rashid Masturah Bte Mohd Abdul , Jayalakshmi  , Lin Yihao Clement , Chee Yen Lin , Fan Bingwen Eugene , De Mel Sanjay , Ooi Melissa Gaik Ming , Jen Wei‐Ying , Chow Edward Kai‐Hua 
Published: November 2024

ABSTRACTBackgroundDespite advances made in targeted biomarker‐based therapy for acute myeloid leukemia (AML) treatment, remission is often short and followed by relapse and acquired resistance. Functional precision medicine (FPM) efforts have been shown to improve therapy selection guidance by incorporating comprehensive biological data to tailor individual treatment. However, effectively managing complex biological data, while also ensuring rapid conversion of actionable insights into clinical utility remains challenging.MethodsWe have evaluated the clinical applicability of quadratic phenotypic optimization platform (QPOP), to predict clinical response to combination therapies in AML and reveal patient‐centric insights into combination therapy sensitivities. In this prospective study, 51 primary samples from newly diagnosed (ND) or refractory/relapsed (R/R) AML patients were evaluated by QPOP following ex vivo drug testing.ResultsIndividualized drug sensitivity reports were generated in 55/63 (87.3%) patient samples with a median turnaround time of 5 (4–10) days from sample collection to report generation. To evaluate clinical feasibility, QPOP‐predicted response was compared to clinical treatment outcomes and indicated concordant results with 83.3% sensitivity and 90.9% specificity and an overall 86.2% accuracy. Serial QPOP analysis in a FLT3‐mutant patient sample indicated decreased FLT3 inhibitor (FLT3i) sensitivity, which is concordant with increasing FLT3 allelic burden and drug resistance development. Forkhead box M1 (FOXM1)—AKT signaling was subsequently identified to contribute to resistance to FLT3i.ConclusionOverall, this study demonstrates the feasibility of applying QPOP as a functional combinatorial precision medicine platform to predict therapeutic sensitivities in AML and provides the basis for prospective clinical trials evaluating ex vivo‐guided combination therapy.
Longitudinal Trends of Comorbidities and Survival Among Kidney Cancer Patients in Asian Population
Authors: Jung Minji , Choo Eunjung , Li Jinhui , Deng Zhengyi , Langston Marvin E. , Lee Sukhyang , Chung Benjamin I. 
Published: November 2024

ABSTRACTBackgroundComorbidity could influence cancer diagnosis, treatment, prognosis, or survival. Although comorbidity burden in kidney cancer patients is high, limited evidence exists on the longitudinal patterns of individual comorbidity prevalence and its impact on overall survival among kidney cancer patients, particularly in Asian populations.MethodsWe included adults diagnosed with kidney cancer between 2010 and 2021 using the Korean nationwide health insurance database. Comorbidities assessed were any 1 of 19 specific medical conditions, diagnosed within 1 year prior to cancer diagnosis. We calculated the incidence and age‐standardized incidence rate of kidney cancer, prevalence of individual medical conditions as single or multiple comorbidities, and overall survival probability of kidney cancer patients over a 12‐year period. We estimated the odds ratio (OR) of having individual and multiple comorbidities with age and sex as independent covariates and adjusted for other comorbidities. Kaplan–Meier curves were used for overall survival at different time frames up to 5 years of follow‐up.ResultsAmong kidney cancer patients (N = 42,740), 68.7% were men, and median (interquartile range) age was 59 (49–68) years. Approximately 76% of patients had at least one comorbidity at the time of cancer diagnosis. Overall, hypertension (51.3%), dyslipidemia (40.2%), mild liver disease (27.4%), diabetes (25.1%), and peptic ulcer disease (18.9%) were the most prevalent comorbidities. The proportion of patients having three or more comorbidities continuously increased from 2010 (29.4%) to 2021 (44.9%). Having more comorbidities was associated with a lower probability of overall survival.ConclusionComorbidities were prevalent in kidney cancer patients, and the proportions of patients with multiple conditions increased over time. Although survival probability increased over time, it was attenuated by having more comorbidities. Our data emphasizes the importance of comprehensive management for both cancer and comorbid conditions in kidney cancer patients.
Transfer Hydrogenative Cleavage of N═N Bond of Azoarenes to Aminoarenes Using Ruthenium Catalyst
Authors: Mohanty Aisa , Sinha Arindam , Kenguva Gowtham , Dandela Rambabu , Daw Prosenjit 
Published: November 2024

AbstractTextile industry contaminants cause significant pollution of water resources, making them a major worry in the modern age. Azo dyes, one of the most harmful synthetic colors generated in textile industry pollutants, are particularly persistent in water bodies due to their chemical composition. In this study, an efficient transfer hydrogenative cleavage of the ─N═N─ moiety containing azoarene to their corresponding aminoarenes is accomplished using a terpyridine‐based ruthenium complex. This report depicts the suitable transformations from the azoarene by adopting a minimal base and catalyst loading. The preliminary mechanistic studies disclosed the selective conversion of azoarenes to its complete ─N═N─ cleavage products, aminoarenes, through the hydrazoarenes intermediate.
Nutation Spectroscopy of a Weakly Interacting Heterobimetallic Spin System
Authors: Appleton Jordan L. , Le Breton Nolwenn , Choua Sylvie , Ruppert Romain , Boudalis Athanassios K. 
Published: November 2024

AbstractThe use of VIV and CuII spins to design weakly coupled and dissymmetric spin systems has been examined. Such systems were synthesized using porphyrin‐based complexes, with external coordination sites allowing for the formation of dimers via a PdII linker ion. Continuous‐wave (CW) Electron Paramagnetic Resonance (EPR) spectroscopy allowed the unequivocal magnetic characterization of the mononuclear precursors VO and Cu. The porphyrin dimer (VO)PdCu presented a broad and overlapped spectrum that was more pronounced than for the previously reported (VO)Pd(VO), hinting at the effect of weak interspin interactions between dissimilar spins. Pulsed EPR experiments on VO, (VO)Pd(VO) and (VO)PdCu samples diluted in a diamagnetic matrix confirmed that this complication is also present in the Field‐Swept Echo‐Detected (FSED) spectra of the heterometallic (VO)PdCu system. Despite the strongly overlapped field‐swept spectra, spin nutation experiments revealed two distinct oscillations in the case of (VO)PdCu, which are assigned to transitions with different spin characters. Remarkably, coherence is retained above liquid nitrogen temperatures for all complexes, in particular up to 295 K for VO and (VO)Pd(VO) and 150 K for (VO)PdCu.
Site‐Selective γ‐Trihalomethylation and γ‐Dihalomethylidenation of Silyl Dienol Ethers under Organophotoredox Catalysis
Authors: Banoun Camille , Bourdreux Flavien , Magnier Emmanuel , Dagousset Guillaume 
Published: November 2024

AbstractWe report a general remote tribromo‐ and trichloromethylation process using CBr4 and CBrCl3 as ready available sources of trihalomethyl radicals. This method operates under mild and metal‐free photocatalyzed conditions and enables the access to γ‐trihalomethylated enals with complete regioselectivity in up to 71 % isolated yield. Importantly, this protocol is easily adapted to the selective one‐pot synthesis of the corresponding γ‐dihalomethylidenated enals in up to 49 % overall yield. Mechanistic studies are in favor of a radical chain propagation initiated by an oxidative quenching of the photocatalyst.
Outcomes of Bolus Dose Furosemide Versus Continuous Infusion in Patients With Acute Decompensated Left Ventricular Failure and Atrial Fibrillation
Authors: Khan Babar , Shuja Darab , Saqib Burhan ul Haq , Liaquat Maria , Malik Jahanzeb , Ashraf Amna , Karim Ali , Ahmed Iftikhar , Akhtar Waheed , Mehmoodi Amin 
Published: November 2024

ABSTRACTBackgroundThis prospective, randomized trial aimed to compare the efficacy and safety of different intravenous diuretic regimens in acute decompensated heart failure (ADHF) patients.MethodsADHF patients were enrolled and randomized into three groups: continuous intravenous furosemide infusion (cIV), bolus furosemide injection (bI), and furosemide plus hypertonic saline solution (HSS). Clinical outcomes were assessed over 48 h.ResultsIn a study involving 1276 patients admitted for ADHF, three therapeutic regimens (T × 1, T × 2, and T × 3) were compared. T × 1 administered an 80 mg furosemide intravenous bolus infusion twice daily to 479 patients, while T × 2 involved a continuous 16‐h infusion of 160 mg furosemide daily to 420 patients. T × 3 treated 377 patients with 160 mg furosemide combined with 150 mL of HSS containing 1.95% NaCl over 30 min. Yet, overall changes in renal markers such as BUN, Na, K, and serum creatinine did not differ significantly. Analysis of prespecified study endpoints revealed notable variations in hospitalization length among the treatment arms. T × 1 demonstrated a significantly shorter hospital stay (3.7 days) compared to T × 2 (6.6 days) and T × 3 (7.9 days). Conversely, alterations in serum creatinine at 48 h, overall changes in serum creatinine, body weight loss, and serum potassium levels did not significantly differ among the treatment groups.ConclusionWhile intravenous bolus of furosemide showed potential benefits in reducing hospitalization duration, limitations such as a small sample size and short‐term observation emphasize the need for larger studies to validate these outcomes further.
The Relationship Between Metacognitive Beliefs and Suicidal Ideation Among Chinese Male Prisoners: A Network Analysis
Authors: Zeng Xiaoqing , Wang Mengye 
Published: November 2024

ABSTRACTBackgroundThe relationship between metacognitive beliefs and suicidal ideation is complex, yet there is limited research exploring ‘the fine‐grained and comorbid pathways between the two variables’, particularly in prisoners.MethodsData were collected from prisoners who completed demographic surveys and psychological scales between February and March 2024. Demographic information included age, educational background and duration of imprisonment. The Metacognitions Questionnaire‐30 (MCQ‐30) and Self‐Rating Idea of Suicide Scale (SIOSS) were administered. Using R 4.2.3 software, a network model of metacognitive beliefs and suicidal ideation was constructed, with expected influence (EI) and bridge expected influence (BEI) calculated to compare the roles of specific symptoms within the network.ResultsThe network model revealed 21 significant edges between metacognitive beliefs and the suicidal ideation community. The most vital edges across communities included ‘Negative beliefs about worry’ and ‘Despair’, ‘Cognitive confidence’ and ‘Despair’, ‘Cognitive self‐consciousness’ and ‘Optimism’, and ‘Cognitive confidence’ and ‘Sleep’ (with edge weights of 0.30, 0.16, −0.16 and 0.11, respectively). ‘Despair’ demonstrated the highest EI value, exerting the strongest impact on the network. The highest BEI values were found for ‘Negative beliefs about worry’ and ‘Despair’.ConclusionNetwork analyses underscore the intricate interplay between metacognitive beliefs and suicidal ideation among prisoners at the symptom level. These findings highlight specific areas for therapeutic focus, potentially leading to more effective mental health support for incarcerated individuals.
Enhancing drought resistance in warm‐season turfgrasses: Fourteen years of progress through a multistate collaborative project across the southern United States
Authors: Gouveia Beatriz Tome , Kenworthy Kevin E. , Chandra Ambika , Schwartz Brian M. , Zhang Jing , Raymer Paul L. , Wu Yanqi , Pudzianowska Marta , Baird James , Miller Grady L. , Unruh J. Bryan , Wherley Benjamin G. , Martin Dennis L. , Moss Justin Q. , Khanal Sameer , Milla‐Lewis Susana 
Published: November 2024

AbstractIn turfgrass breeding, drought resistance is a primary trait for improvement due to scarcity and reduced quality of water for irrigation. Therefore, in 2010, the turfgrass breeding programs at six public universities joined efforts to address these challenges by cross evaluating breeding lines for the most economically significant warm‐season turfgrass species in the southern United States through a United States Department of Agriculture‐National Institute for Food and Agriculture Specialty Crop Research Initiative funded project. Three breeding cycles were associated with three completed (2010–2014, 2014–2019, and 2019–2024) collaborative grant projects, but the efficiency of this partnership in terms of gains from selection has not been measured. Our objectives were to (1) estimate the expected and realized genetic gain for drought resistance and turfgrass quality for three breeding cycles, (2) compare cultivars developed with support of the projects versus standard cultivars in a historical data analysis, and (3) compare genetic gain for traits assessed visually versus using small unmanned aircraft systems imagery, both in drought and non‐drought environments. For these purposes, historical data were investigated with a retrospective analysis of project trials evaluated 2011–2024. Our findings for the realized genetic gain demonstrated progress in enhancing drought resistance in bermudagrass, St. Augustinegrass, seashore paspalum, and zoysiagrass. In addition, notable positive increments for this trait were documented for each cycle compared to the standard cultivars, particularly in bermudagrass, St. Augustinegrass, and zoysiagrass. While heritability was higher for visually assessed traits, genetic increments were more pronounced for imagery‐assessed traits.
Transcriptomic and metabolomic analysis reveal differentially expressed genes and metabolic pathways in bermudagrass under drought stress
Authors: Seelam Ravi Teja , Jespersen David 
Published: November 2024

AbstractDrought stress poses a significant challenge to turfgrass growth, particularly in the regions like southern United States, where bermudagrass (Cynodon sp.) is widely used for lawns and sports fields. Drought stress disrupts physiological processes, leading to reduced water availability, impaired photosynthesis, and oxidative stress. To understand the bermudagrass response to drought, we investigated the physiological differences and characterized the gene expression and metabolite profiles in two bermudagrass genotypes, TifTuf and Premier. Physiological measurements showed significant variations in green cover percentage, visual quality, and relative water content between the two genotypes. RNA sequencing revealed extensive gene expression changes, with differentially expressed genes that were upregulated in both genotypes. Gene ontology (GO) analysis highlighted biological processes such as transcription regulation, lipid metabolism, and cellular structure development pathways. KEGG pathway analysis indicated that TifTuf had significant changes in galactose metabolism, carotenoid biosynthesis, and plant hormone signal transduction pathways, while Premier showed enrichment in plant hormone signaling, lipid metabolism, and secondary metabolite biosynthesis pathways. Metabolomic analysis provided insights into metabolic reprogramming due to drought stress. Principal component analysis revealed distinct metabolic patterns between control and drought‐stressed samples, with both genotypes showing substantial alterations. Differential metabolite analysis identified key metabolites associated with stress adaptation, including the phytohormone ABA and various amino acids. This analysis elucidates the intricate physiological and molecular mechanisms underlying drought tolerance in bermudagrass genotypes. These findings enhance the understanding of drought stress adaptation strategies in bermudagrass and offer valuable insights for the development of drought‐tolerant genotypes.
Ni/PiNe Heterogeneous Catalyst from Biomass Waste: Low‐Loading, Ligand‐Free Suzuki‐Miyaura Cross‐Coupling
Authors: Valentini Federica , Chen Shaomin , Brufani Giulia , Gu Yanlong , Vaccaro Luigi 
Published: November 2024

AbstractAn efficient Ni‐based heterogeneous catalyst from pine needles urban waste valorization was designed and developed with a resource recycling strategy. The Ni/PiNe catalyst was fully characterized and tested in the Suzuki‐Miyaura coupling under microwave irradiation. Although Ni is a promising candidate for replacing Pd‐based catalytic systems, it generally requires a high catalyst amount and the exploitation of ligands and additives to enhance the reaction rate. On the contrary, with our new Ni/PiNe, 30 different products were efficiently synthesized with an isolated yield of up to 93 %, using a very low catalyst amount and in the absence of ligands. Furthermore, the Ni/PiNe catalyst also showed good durability for consecutive cycles and an impressive TON value (1140). In addition to the catalytic efficiency in short reaction time and to the stability and durability under MW irradiation, the Ni/PiNe allowed for further optimization, achieving a low E‐factor value (14.0), thus highlighting the potential in further reducing the waste and costs associated to the process.
Systematic Synthesis of DC–DC Converters Based on Loop Matrices
Authors: Zhang Yang , Qiu Dongyuan , Zhang Bo , Chen Yanfeng , Zeng Yangbin 
Published: November 2024

ABSTRACTFlux balance method and state equation method are representative methods to synthesize DC–DC converters according to given conditions. Both of them include a step to synthesize DC–DC converters from equivalent circuits of different intervals, which is difficult to process by manual synthesis. Considering the equivalent circuits can be transformed into loop matrices, a systematic synthesis method of DC–DC converters based on loop matrices is proposed in this paper. The proposed method transforms volt‐second balance equations or state equations into loop matrix in each switching interval, and then outputs all the corresponding DC‐DC converters. As an example, 11 DC–DC converters with the voltage gain of D2 is synthesized by the proposed method, six of which are firstly proposed. To compare their performances and select the best one, an evaluation index system is constructed, simulations of the converters are carried out to obtain the values of the indices, and analytic hierarchy process (AHP) and entropy method are used to evaluate the converters. Prototypes of the best two converters are built, and the experimental results verify the effectiveness of the proposed synthesis and evaluation method.
The contribution of the CRP/CD64 axis to renal cancer progression by inducing protumor activation of tumor‐associated macrophages
Authors: Pan Cheng , Fujiwara Yukio , Yano Hiromu , Anami Toshiki , Ibe Yuki , Li Lianbo , Miura Yuji , Motoshima Takanobu , Esumi Shigeyuki , Yatsuda Junji , Hibi Taizo , Kamba Tomomi , Komohara Yoshihiro 
Published: November 2024

AbstractObjectivesC‐reactive protein (CRP) is a well‐known acute‐phase protein that increases remarkably under various inflammatory conditions and is elevated in patients with malignant tumors. In this study, we investigated the influence of CRP on the tumor microenvironment in clear cell renal cell carcinoma (ccRCC).MethodsThis study explored CRP's role in ccRCC by co‐culturing human macrophages with ccRCC cells and employing antibody blocking, RNA sequencing and in vitro experiments for functional insights. We also analysed The Cancer Genome Atlas Program (TCGA) data to link CD64 expression with ccRCC prognosis and used immunohistochemistry to associate CD64+ macrophages with tumor severity and systemic CRP levels.ResultsA co‐culture study using human macrophages and RCC cell lines showed that CRP‐stimulated macrophages secrete IL‐6, which induces RCC proliferation via STAT3 activation. CRP‐induced protumor activation of macrophages was suppressed by CD64 blocking antibodies. Furthermore, CRP elevates PD‐L1 expression in macrophages via the CD64‐STAT1 signalling pathway. Statistical analysis of TCGA data indicated that increased CD64 expression was associated with a worse clinical course in ccRCC. Immunohistochemical analysis of pathological specimens revealed that high CD64 expression in tumor‐associated macrophages (TAMs), and a high density of CD64+ TAMs, was linked to high nuclear grade and stage. High CD64 expression was also correlated with increased serum CRP levels.ConclusionsThe CRP‐CD64 signal was linked to the protumor activation of TAMs and could be a promising target for anticancer immunotherapy in ccRCC.