bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal Influenza Vaccines: Progress in Achieving Broad Cross-Protection In Vivo
Authors: Epstein Suzanne L 
Published: August 2018

AbstractDespite all we have learned since 1918 about influenza virus and immunity, available influenza vaccines remain inadequate to control outbreaks of unexpected strains. Universal vaccines not requiring strain matching would be a major improvement. Their composition would be independent of predicting circulating viruses and thus potentially effective against unexpected drift or pandemic strains. This commentary explores progress with candidate universal vaccines based on various target antigens. Candidates include vaccines based on conserved viral proteins such as nucleoprotein and matrix, on the conserved hemagglutinin (HA) stem, and various combinations. Discussion covers the differing evidence for each candidate vaccine demonstrating protection in animals against influenza viruses of widely divergent HA subtypes and groups; durability of protection; routes of administration, including mucosal, providing local immunity; and reduction of transmission. Human trials of some candidate universal vaccines have been completed or are underway. Interestingly, the HA stem, like nucleoprotein and matrix, induces immunity that permits some virus replication and emergence of escape mutants fit enough to cause disease. Vaccination with multiple target antigens will thus have advantages over use of single antigens. Ultimately, a universal vaccine providing long-term protection against all influenza virus strains might contribute to pandemic control and routine vaccination.
Microsimulation model to predict incremental value of biomarkers added to prognostic models
Authors: Pencina Karol M , D’Agostino Ralph B , Vasan Ramachandran S , Pencina Michael J 
Published: August 2018

Abstract
It is unclear to what extent simulated versions of real data can be used to assess potential value of new biomarkers added to prognostic risk models. Using data on 4522 women and 3969 men who contributed information to the Framingham CVD risk prediction tool, we develop a simulation model that allows assessment of the added contribution of new biomarkers. The simulated model matches closely the one obtained using real data: discrimination area under the curve (AUC) on simulated vs actual data is 0.800 vs 0.799 in women and 0.778 vs 0.776 in men. Positive correlation with standard risk factors decreases the impact of new biomarkers (ΔAUC 0.002-0.024), but negative correlation leads to stronger effects (ΔAUC 0.026-0.101) than no correlation (ΔAUC 0.003-0.051). We suggest that researchers construct simulation models similar to the one proposed here before embarking on larger, expensive biomarker studies based on actual data.
Long-Term Hearing Outcomes Following Stereotactic Radiosurgery in Vestibular Schwannoma Patients—A Retrospective Cohort Study
Authors: Santa Maria Peter L , Shi Yangyang , Gurgel Richard K , Corrales C Eduardo , Soltys Scott G , Santa Maria Chloe , Murray Kevin , Chang Steven D , Blevins Nikolas H , Gibbs Iris C , Jackler Robert K 
Published: August 2018

Abstract

BACKGROUND
An understanding of the hearing outcomes is needed for treatment counseling for patients with vestibular schwannomas (VS).

OBJECTIVE
To determine long-term hearing results following stereotactic radiosurgery (SRS) for VS and identify any influential variables.

METHODS
Tertiary hospital retrospective cohort.

RESULTS
There were 579 tumors (576 patients) treated with SRS. Eighty-two percent (473) of tumors had ≥1 yr and 59% (344 ≥3 yr follow-up. In the 244 tumor ears, with measurable hearing before SRS who were followed ≥1 yr, 14% (31) had improved hearing, 13% (29) unchanged hearing, and 74% (158) had worsened hearing. In 175 patients with ≥3 yr follow-up and who had measurable hearing pretreatment, 6% (11 ears) improved hearing, 31% (54 ears) unchanged hearing, and 63% (110 ears) had worsened hearing. Patients with tumors with larger target volumes (P = .040) and with neurofibromatosis type 2 (NF2; P = .017) were associated with poorer hearing (P = .040). Patients with word recognition scores (WRS) of 50% or poorer had tumors with a larger volume (P = .0002), larger linear size (P = .032), and NF2 (P = .045). Traditionally reported hearing outcomes using the Gardner Robertson maintenance of PTA ≤50 db or WRS ≥50% were 48% at 3 yr, which overestimates hearing outcomes compared to the above reporting standards.

CONCLUSION
Hearing declines over time in VS treated with SRS in a high proportion of cases. The frequency and magnitude of long-term hearing decline following SRS argues against prophylactic radiation for small tumors in hearing ears with undetermined growth behavior.
Koos Classification of Vestibular Schwannomas: A Reliability Study
Authors: Erickson Nicholas J , Schmalz Philip G R , Agee Bonita S , Fort Matthew , Walters Beverly C , McGrew Benjamin M , Fisher Winfield S 
Published: August 2018

Abstract

BACKGROUND
The Koos classification of vestibular schwannomas is designed to stratify tumors based on extrameatal extension and compression of the brainstem. While this classification system is widely reported in the literature, to date no study has assessed its reliability.

OBJECTIVE
To assess the intra- and inter-rater reliability of the Koos classification system.

METHODS
After institutional review board approval was obtained, a cross-sectional group of the Magnetic Resonance imagings of 40 patients with vestibular schwannomas varying in size comprised the study sample. Four raters were selected to assign a Koos grade to 50 total scans. Inter- and intrarater reliability were calculated and reported using Fleiss’ kappa, Kendall's W, and Intraclass correlation coefficient (ICC).

RESULTS
Inter-rater reliability was found to be substantial when measured using Fleiss' kappa (.71), extremely strong using Kendall's W (.92), and excellent as calculated by ICC (.88).
Intrarater reliability was perfect for 3 out of 4 raters as assessed using weighted kappa, Kendall's W and ICC, with the intrarater agreement for the fourth rater measured as extremely high.

CONCLUSION
We have demonstrated that the Koos classification system for vestibular schwannoma is a reliable method for tumor classification. This study lends further support to the results of current literature using Koos grading system. Further studies are required to evaluate its validity and utility in counseling patients with regard to outcomes.
Single-atom catalyst: a rising star for green synthesis of fine chemicals
Authors: Zhang Leilei , Ren Yujing , Liu Wengang , Wang Aiqin , Zhang Tao 
Published: August 2018

Abstract
The green synthesis of fine chemicals calls for a new generation of efficient and robust catalysts. Single-atom catalysts (SACs), in which all metal species are atomically dispersed on a solid support, and which often consist of well-defined mononuclear active sites, are expected to bridge homogeneous and heterogeneous catalysts for liquid-phase organic transformations. This review summarizes major advances in the SAC-catalysed green synthesis of fine chemicals in the past several years, with a focus on the catalytic activity, selectivity and reusability of SACs in various organic reactions. The relationship between catalytic performance and the active site structure is discussed in terms of the valence state, coordination environment and anchoring chemistry of single atoms to the support, in an effort to guide the rational design of SACs in this special area, which has traditionally been dominated by homogeneous catalysis. Finally, the challenges remaining in this research area are discussed and possible future research directions are proposed.
High-Flow Nasal Cannula Practice Patterns Reported by Neonatologists and Neonatal Nurse Practitioners in the United States
Authors: Eklund Wakako Minamoto , Scott Patricia A. 
Published: August 2018

Background:
High-flow nasal cannula (HFNC) is widely used to treat neonatal respiratory conditions. Significant evidence emerged in recent years to guide practice, yet current practice patterns and their alignment with the evidence remain unknown.

Purpose:
To examine current HFNC practice patterns and availability of clinical practice guidelines used in neonatal intensive care units in the United States.

Methods/Analysis:
A nonexperimental, descriptive study was designed using a web-based survey to elicit a convenience sample of US neonatal providers. Quantitative data were analyzed using descriptive statistics, χ2 tests were used to test for differences among the categories, and post hoc comparisons among each combination of categories were conducted using a Bonferroni-corrected α of .05 to determine significance as appropriate.

Results:
A total of 947 responses were analyzed (626 neonatologists and 321 neonatal nurse practitioners). Univariate analyses suggested wide variations in practice patterns. One-third of the respondents used clinical guidelines, the majority utilized HFNC devices in conjunction with nasal continuous positive airway pressure, more than two-thirds used HFNC as a primary respiratory support treatment, and among all respondents, significant differences related to HFNC device types were reported.

Implications for Practice:
US providers revealed wide practice variations related to HFNC therapy. In addition, type of device used appears to impact practice patterns and approaches. Use of standardized guidelines was reported by one third of the respondents, and as such may be the contributing factor for wide practice variations.

Implications for Research:
Future Research is needed to target aspects of practice where practice variations exist, or practice is not supported by evidence. Significant practice differences related to the device types should be considered in future research design.
Changing Hearing Performance and Sound Preference With Words and Expectations: Meaning Responses in Audiology
Authors: Hodgetts William E. , Aalto Daniel , Ostevik Amberley , Cummine Jacqueline 
Published: August 2018

Objectives:
In this article, we explore two manipulations of “meaning response,” intended to either “impart” meaning to participants through the manipulation of a few words in the test instructions or to “invite” meaning by making the participant feel involved in the setting of their preferred sound.

Design:
In experiment 1, 59 adults with normal hearing were randomly assigned to one of the two groups. Group 1 was told “this hearing in noise test (HINT) you are about to do is really hard,” while the second group was told “this HINT test is really easy.” In experiment 2, 59 normal-hearing adults were randomly assigned to one of two groups. Every participant was played a highly distorted sound file and given 5 mystery sliders on a computer to move as often and as much as they wished until the sound was “best” to them. They were then told we applied their settings to a new file and they needed to rate their sound settings on this new file against either (1) another participant in the study, or (2) an expert audiologist. In fact, we played them the same sound file twice.

Results:
In experiment 1, those who were told the test was hard performed significantly better than the easy group. In experiment 2, a significant preference was found in the group when comparing “my setting” to “another participant.” No significant difference was found in the group comparing “my setting” to the “expert.”

Conclusions:
Imparting or inviting meaning into the context of audiological outcome measurement can alter outcomes even in the absence of any additional technology or treatment. These findings lend support to a growing body of research about the many nonauditory factors including motivation, effort, and task demands that can impact performance in our clinics and laboratories.
Advances in the early diagnosis and therapy of inclusion body myositis
Authors: Lilleker James B. 
Published: August 2018

Purpose of reviewTo describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM).Recent findingsOur understanding of the implications of anti-cytosolic 5′-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance techniques and ultrasound is increasingly being performed and characteristic patterns of muscle involvement may help with diagnosis. Longitudinal imaging studies are likely to help with monitoring and as an outcome measure in clinical trials. Recent small-scale studies of Arimoclomol and Rapamycin have shown promising results and further investigation of these medications is ongoing. Exercise is likely to form an increasingly important facet of management of patients with IBM, but the optimal type of exercise programme to enrol patients in is not yet determined.SummaryAntibody testing and muscle imaging results may improve our ability to diagnose IBM and the availability of effective disease modifying treatments targeting novel non-inflammatory pathways could soon become a reality. It remains the duty of those involved in the management of patients with IBM to facilitate involvement in clinical trials and other research studies.
Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy?
Authors: Gyftaki-Venieri Dafni A. , Abraham David J. , Ponticos Markella 
Published: August 2018

Purpose of review
The persistence of myofibroblasts is a key feature of fibrosis and in fibrotic diseases including scleroderma. This review evaluates the emerging concepts of the origins and cell populations that contribute to myofibroblasts and the molecular mechanisms that govern phenotypic conversion and that highlight opportunities for new interventional treatments in scleroderma.

Recent findings
Studies have defined heterogeneity in fibroblast-like cells that can develop into myofibroblast in normal wound healing, scarring and fibrosis. Characterizing these distinct cell populations and their behaviour has been a key focus. In addition, the overarching impact of epigenetic regulation of genes associated with inflammatory responses, cell signalling and cell communication and the extracellular matrix (ECM) has provided important insights into the formation of myofibroblast and their function. Important new studies include investigations into the relationship between inflammation and myofibroblast production and further evidence has been gathered that reveal the importance of ECM microenvironment, biomechanical sensing and mechanotransduction.

Summary
This review highlights our current understanding and outlines the increasing complexity of the biological processes that leads to the appearance of the myofibroblast in normal functions and in diseased tissues. We also focus on areas of special interest in particular, studies that have therapeutic potential in fibrosis and scleroderma.
Evidence-based Recommendations for Pediatric Orthopaedic Practice
Authors: Mulpuri Kishore , Schaeffer Emily K. , Sanders James , Zaltz Ira , Kocher Mininder S. 
Published: August 2018

Background:
The evidence-based approach to guide clinical practice has gained great importance in the medical field. High-quality evidence is of paramount importance to inform clinical decision-making and optimize patient outcomes. The generation of high-quality evidence relies on sound methodology and study design to facilitate appropriate interpretation and subsequent application of the clinical findings. The purpose of this review is to objectively critique the methodological design and clinical findings of 2 pediatric orthopaedic studies on children with cerebral palsy (CP) to assess their potential to impact clinical practice.

Methods:
This is the second in a series of evidence-based reviews in pediatric orthopaedics. The pediatric orthopaedic literature was reviewed for randomized controlled trials (RCTs) published in 2015 and 2016. One RCT was selected from the journal Pediatrics, and one RCT was selected from the journal Developmental Medicine and Child Neurology, both investigating the use of botulinum toxin for the treatment of spastic equinus in children with CP. These RCTs were subjected to in-depth methodological review by orthopaedic surgeons with advanced research degrees and a PhD researcher. Two clinical experts then reviewed the articles to rate the clinical impact or value of each study. Methodological and clinical reviews were compiled, and a final recommendation on impact to change clinical practice was made based on both review components at the consensus of the panel.

Results:
The first study reviewed investigated the single-dose efficacy and safety of botulinum neurotoxin type-A (1BoNT-A) in children with CP-associated spasticity and equinus foot deformity. The reviewers deemed the placebo-controlled study to be of sound design, and conclusions appropriate for the methodology used and clinical findings. Although findings suggest 1BoNT-A may provide benefit in treating equinus foot deformity, the optimal dose for achieving maximal impact on functional improvement remains undetermined. The second study reviewed investigated the impact of multiple dosing schedules on spastic equinus in CP. Although of relatively sound design, this study was limited by a small sample size and lack of justification for the chosen effect size. Without further study, no recommendation to change clinical practice could be made.

Conclusions:
Both RCTs reviewed were superiority studies, the first demonstrating efficacy of botulinum toxin over placebo, the second showing no significant difference in 4- and 12-monthly botulinum toxin injections.

Significance:
Despite a positive result demonstrating an effect of botulinum toxin treatment on spastic equinus in CP, the long-term functional impact and optimal dose remains to be determined. In addition, the negative result in the second study demonstrates the need for a noninferiority trial design to appropriately demonstrate no difference between 2 treatment options.
The Recognition, Incidence, and Management of Spinal Cord Monitoring Alerts in Pediatric Cervical Spine Surgery
Authors: Mohammad Waleed , Lopez Denise , Isley Michael , Phillips Jonathan H. 
Published: August 2018

Background:
Perioperative spinal cord injury and postoperative neurological deficits are the major complications in spinal surgery. Monitoring of spinal cord function is of crucial importance. Somatosensory evoked potentials and transcranial electric motor-evoked potentials are now widely used in cervical spine surgery. Although much has been written on spinal cord monitoring in adult spinal surgery, very little has been published on the incidence and management of monitoring of cervical spine surgery in the pediatric population. The goal of this research was to review the recognition, incidence, and management of spinal cord monitoring in pediatric patients undergoing cervical spine surgery over the course of twenty years in a single institution. We postulate spinal cord monitoring alerts in pediatric cervical spine surgery are underreported.

Methods:
An IRB-approved retrospective single institution review of pediatric cervical spine cases from 1997 to 2017 was performed. Both the surgeon’s dictated operative note and the neuromonitoring team’s dictated note were reviewed for each case, and both were cross referenced and correlated with one another to ensure no alerts were missed. All monitoring changes were assumed to be significant and reported. The incidence of alerts, type of changes, and corrective maneuvers were noted. New postoperative neurological injuries were recorded.

Results:
From 1997 to 2017 fifty-three patients underwent a total of 69 procedures involving the cervical spine. Fourteen procedures (20%) were not monitored, whereas 55 procedures were 80%. There were 12 procedures (21.8%) complicated by neuromonitoring alerts.

Conclusions:
The number of cases complicated by alerts doubles that previously reported, and it is important to note there were no new permanent neurological deficits recorded over the study period. Corrective strategies were implemented once the operating surgeon was notified of the neuromonitoring alert. Aborting the case was then considered if corrective strategies failed to restore baseline neurophysiology.

Level of Evidence:
Level IV.
Magnetic Intramedullary Lengthening Nails and MRI Compatibility
Authors: Gomez Charles , Nelson Scott , Speirs Joshua , Barnes Samuel 
Published: August 2018

Background:
Magnetic intramedullary nails (IMNs) are fully implantable lengthening devices that became available in the United States in 2011 for the correction of limb length discrepancies. This device represents a major advancement in the field of limb lengthening surgery as it is typically tolerated better than external fixation. Unlike traditional IMNs, surgeons recommend routine removal following limb lengthening. One such reason involves patient safety as it pertains to magnetic resonance imaging (MRI). Theoretical concerns with MRI exposure include implant migration, implant heating, and involuntary elongation of the lengthening mechanism. Our study seeks to investigate the effects of MRI on intramedullary magnetic lengthening nails.

Methods:
Twenty-five intramedullary magnetic nails were studied. One nail was placed within the magnetic field to measure maximum magnetic force. Nails were then scanned using standard knee MRI protocols, 12 in 3 T and 12 in 1.5 T MRI scanners. The following parameters were measured: (1) distraction of the implants after MRI exposure, (2) temperature before and after MRI, and (3) internal distraction force before and after MRI.

Results:
Maximum magnetic force was found to be 2 lbs. There was no involuntary distraction of the implants after MRI. Temperature increase of 3.3°C was found in the femoral nails and 3.6°C in the tibial nails that were exposed to 3 T MRI. This increase did not reach or exceed physiological temperature of 37°C. Distraction force was reduced by 61.7% in the femoral nails and 89.6% in the tibial nails after subjected to 3 T MRI. There was no reduction in distraction force after exposure to 1.5 T MRI.

Conclusions:
Recommendations for routine removal of magnetic IMNs for safety concerns should be reconsidered. Exposure to 3 T MRI should be avoided in patients who are still undergoing lengthening or with plans for future lengthening with magnetic IMNs.

Clinical Relevance:
To assess patient safety and implant function after magnetic IMNs have been exposed to MRI.