bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Pregnancy Outcomes in Preimplantation Genetic Testing for Aneuploidy and Conventional In Vitro Fertilization and Embryo Transfer: A Stratified Examination on the Basis of the Quantity of Oocytes and Blastocysts From a Multicenter Randomized Controlled Trial
Authors: Hu Min , Liu Mingxi , Tian Siqi , Guo Ling , Zang Zhaowen , Chen Zi-Jiang , Li Yan 
Published: November 2024

(Abstracted from Fertil Steril 2024;122:121–130)
Recent advances in assisted reproductive technology have increased the ability of many couples to have children, with more than 8 million children being born using in vitro fertilization (IVF) since the technique was first introduced. Though IVF increases the chance of a pregnancy, implantation failure and miscarriage can still occur.
Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics
Authors: Kranawetter Beate , Brockmöller Jürgen , Sindern Juliane , Hapke Anne , Bruns Ellen , Harnisch Lars-Olav , Moerer Onnen , Stenzig Justus , Mielke Dorothee , Rohde Veit , Abboud Tammam 
Published: November 2024

OBJECTIVES:
Subarachnoid hemorrhage (SAH) may critically impair cardiovascular, metabolic, and gastrointestinal function. Previous research has demonstrated compromised drug absorption in this group of patients. This study aimed to examine the impact of SAH on gastrointestinal function and its subsequent effect on the absorption of enterally administered drugs, using esomeprazole as a probe drug.

DESIGN:
Prospective observational cohort study.

SETTING:
Academic hospital in Germany.

PATIENTS:
We included 17 patients with high-grade SAH and 17 controls, comparable in age, sex, body weight, and renal function, who underwent elective cranial surgery.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Both groups received esomeprazole per standard protocol to prevent acid-associated mucosal damage, either orally or through a nasogastric tube. On day 4, esomeprazole was administered IV to estimate oral bioavailability. Esomeprazole serum concentrations were measured on days 1, 3, and 4 in both groups and on day 7 in the SAH group. Patients with high-grade SAH exhibited severely impaired drug absorption. Most patients showed no improvement in intestinal drug absorption even a week after hemorrhage.

CONCLUSIONS:
Following SAH, significantly reduced drug absorption may be attributed to decreased intestinal motility and compromised intestinal mucosal function. Clinicians should anticipate the reduced effectiveness of enterally administered medications for at least seven days after high-grade SAH.
Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis
Authors: Li Wenzhu , Chi Yongquan , Xiao Xuan , Li Junda , Sun Mingmin , Sun Shanke , Xu Wei , Zhang Long , Li Xiaoguo , Cheng Feng , Qi Xiaolong , Rao Jianhua 
Published: November 2024

Background and Aims:
Reliable novel noninvasive biomarkers for the diagnosis of advanced liver fibrosis are urgently needed in clinical practice. We aimed to investigate the accuracy of plasma Follistatin-like protein 1 (FSTL-1) in the diagnosis of advanced liver fibrosis in chronic liver diseases.

Approach and Results:﻿
We collected cross-sectional clinical data for a derivation cohort (n = 86) and a validation cohort (n = 431), totaling 517 subjects with liver biopsy. Advanced liver fibrosis was defined by the METAVIR pathological score (F ≥3). Dual cutoff values for diagnosis were explored. In the derivation cohort, plasma FSTL-1 levels were significantly elevated in patients with advanced liver fibrosis, with an AUROC of 0.85 (95% CI, 0.75–0.96). In the validation cohort, plasma FSTL-1 maintained good diagnostic performance, with an AUROC of 0.88 (95% CI, 0.83–0.92). Plasma FSTL-1 levels were significantly associated with individual histological features of the METAVIR scoring system, including interface hepatitis, lobular necrosis, and hepatocellular ballooning (p < 0.0001). A cutoff value ≤ 0.43 ng/mL was the optimal rule-out threshold, with a sensitivity of 84.62% (95% CI, 76.46%–90.30%) and a specificity of 79.51% (95% CI, 74.81%–83.53%), while ≥0.50 ng/mL was the best rule-in threshold, with a specificity of 86.41% (95% CI, 81.06%–90.43%) and a sensitivity of 70.67% (95% CI, 64.41%–76.23%).

Conclusions:
Plasma FSTL-1 has high diagnostic accuracy and could potentially reduce the need for liver biopsy in identifying patients with advanced liver fibrosis.
A New Method to Measure Ocular Surface Sensitivity: Repeatability and Reproducibility of the Liquid Jet Esthesiometer
Authors: Ehrmann Klaus , Talens-Estarelles Cristian , Stapleton Fiona , Truong Brenda , Chen Jessica , Golebiowski Blanka 
Published: November 2024

Objectives:
To assess the reliability of the liquid jet esthesiometer (LJA) for measurement of corneal sensitivity.

Methods:
Two separate studies were conducted to assess intrasession repeatability (study 1) and intersession reproducibility (study 2) of corneal sensitivity measured using the LJA. Thirty participants (13 female and 17 male participants, age 23±6 years) participated in study 1 and another 30 (18 female and 12 male participants, 35±10 years) participated in study 2. For study 1, mechanical sensation threshold of the central cornea was measured three times on the same day, with a 30-min break between repeats. For study 2, central corneal sensation threshold was measured on five different days by one of eight randomly assigned examiners.

Results:
Corneal sensation thresholds obtained in studies 1 and 2 were 2.3±1.0 and 2.5±1.2 μL, respectively. No significant differences between repeated measurements were obtained in either study (P≥0.19). Thresholds were lower (i.e., corneal sensitivity was higher) in female than male participants (2.1±1.0 vs. 2.7±0.9 μL in male participants, P=0.02) but were not affected by contact lens wear. Clinical reliability of the LJA was good for intrasession repeatability (coefficient of repeatability ±1.6 μL, intraclass correlation coefficient 0.74, within-subject coefficient of variation (CVW) 24%) and moderate for intersession reproducibility (Coefficient of Reproducibility ±2.2 μL, CVW 32%). Measurement variability was independent of threshold level (P=0.84).

Conclusions:
The LJA offers good clinical repeatability and is a reliable tool to measure corneal sensitivity in different population groups, regardless of stimulus thresholds. Day-to-day fluctuations in corneal sensitivity probably account for the relatively lower reproducibility.
A Scoping Review of Motor and Language Measurement Tools Used in Early Childhood Research
Authors: DeVeney Shari , Chaudhary Priyanka , Heyne Brooke , Rech John , Dinkel Danae 
Published: November 2024

Early childhood is a critical period characterized by rapid development of motor and language skills. Reliably assessing motor and language development in early childhood is difficult, and there is a lack of agreement on measurement tool use. This scoping review aims to identify measurement tools used to examine motor and language skills in infants and young children (0–5 years) when the relationship between these two domains is studied. A scoping review of existing literature on motor and communication skills was conducted across studies measuring gross and/or fine motor and language development in children aged 0–5 years. Systematic searches were conducted in six online databases using carefully selected keywords and search parameters. The resulting corpus of existing literature was reviewed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses. Sixty motor and 99 language measurement tools were found. The most used measurement tools for motor and language skills were the Bayley Scales of Infant and Toddlers Development, Ages and Stages Questionnaire, Mullen Scales of Early Learning, MacArthur–Bates Communicative Development Inventories, Vineland Adaptive Behavior Scales, and Gross Motor Function Classification System. Of these, the measurements used to address language skills did not include reference to all language aspects, particularly lacking were emphasis on skills associated with phonology, morphology, and pragmatics with more focused attention on the semantic language component. This study refines existing knowledge about commonly used early childhood measurement tools. This may help to inform research and encourage consistent measurement use across studies as well as in clinical practice to improve reliable comparisons across outcomes and use measurement tools with diagnostic purpose. Further, a broader inclusion of discrete language components within measurement tools is warranted to better determine the rich, nuanced relationship between early motor and language skills.
The relationship between meeting workplace accommodation needs and job disruptions among Canadians working with disabilities: A cross-sectional analysis
Authors: Jessiman-Perreault Geneviève , Smith Peter , Thompson Aaron , Gignac Monique A. M. 
Published: November 2024

Abstract

Objective
This research explores whether having accommodation needs met reduces job disruptions.

Methods
A cross-sectional survey (n = 955) of Canadians working with physical and/or mental/cognitive disabilities was used to assess the association between having workplace accommodations (i.e., flexibility, modifications) needs met and four types of job disruptions. Analyses used marginal effects models to adjust for demographic and work context variables.

Results
Participants with work modification needs met had a 7.7% decrease in lost work time. Participants with workplace flexibility needs met had a 9.9% percent increase in lost work time. Having workplace flexibility or modification needs met were not associated with the other job disruption outcomes.

Conclusions:
Modifications may help to reduce lost work time for workers with disabilities. Flexibility may increase lost time which is explained by it enabling workers to attend to personal needs during working hours.
The impact of air pollution on acute angle-closure glaucoma in Hefei, China, 2017-2022: a time-series study
Authors: Zhang Si-Tian , Wang Li-Qing , Fang Yan-Cheng , Shen Wen-Bin , Li Ying-Long , Sun Bing , Li Yong-Rong , Huang Xue-Hai , Liu He-Ting , Huang Fen , Zhou Yan-Feng 
Published: November 2024

Abstract

Objective: The study investigated the effects of air pollutants on the incidence of acute angle-closure glaucoma (AACG) in Hefei, China.

Methods: A combination of generalized additive models (GAM) and distributed lag non-linear models (DLNM) was used to explore the relationship between air pollutants and the incidence of AACG.

Results: Exposure-response curves showed that exposure to PM2.5, PM10, NO2, SO2, CO, and O3 were all positively correlated with the onset of AACG. Among them, NO2, and CO having higher relative risk values for AACG onset.

Conclusions: This study highlighted the potential risks of these pollutants and expanded the knowledge of the environmental role in AACG incidence, which will encourage local governments to adopt policy measures and guidance to improve public health.
Association between the occupation of pregnant women’s partners and risks of infant low birth weight and preterm birth in a prospective birth cohort: the Japan Environment and Children’s Study
Authors: Kobayashi Sumitaka , Saijo Yasuaki , Iwata Hiroyoshi , Yamaguchi Takeshi , Tamura Naomi , Itoh Mariko , Tojo Maki , Ito Yoshiya , Kishi Reiko ,   The Japan Environment and Children’s Study (JECS) Group
Published: November 2024

Abstract

Objective
We examined the association between the occupations of pregnant women’s partners and infant low birth weight (LBW) and preterm birth (PB).

Methods
Birth outcome data were collected from 46,540 participants enrolled in the Japan Environment and Children’s Study. Participants were recruited from January 2011 to March 2014. Associations between the occupations of pregnant women’s partners and birth outcomes were examined using logistic regression models adjusted for confounding factors.

Results
LBW and PB incidences were 7.5% and 4.1%, respectively. In the major occupational group, the odds ratios (95% confidence intervals) of LBW for clerical (1.19; 1.03-1.37) and service workers (1.21; 1.05-1.39) were higher than those for professional and engineering workers. However, no associations existed between the major occupational groups of the pregnant women’s partners and PB.

Conclusion
Partner’s employment in clerical and service work increases the risk for LBW.
Psychosocial Stress at Work and Risks for Burnout Among Hotel Workers
Authors: Rosemberg Marie-Anne S. , Ghosh Bidisha , Jun Jin , Armijo Julianne , Marriott Deanna J 
Published: November 2024

Abstract

Objective
Hotel workers are at risk for burnout. We tested the association between effort-reward imbalance (ERI) and burnout.

Methods
Participants were recruited through social media and completed an online survey. ERI and burnout were analyzed using an adjusted multivariable regression model.

Results
224 hotel workers were surveyed. 83% were female, 38% were guest room attendants, and 19% were in leadership. Most were white (62%), non-unionized (78%), and worked full-time (76%). The mean age was 39.4 (SD = 13). The mean burnout score was 41.8 (SD = 6.6, range of 20.0-59.0). 50.5% of participants reported high ERI, especially among leadership, food workers, and guest room attendants.

Conclusions
High ERI was associated with higher burnout. Older age was associated with reduced burnout. Hotel workers experience high levels of stress. Targeted interventions are necessary to foster coping and mitigate risk factors.
GLP-1 Receptor Agonist Induced Eustachian Tube Dysfunction: Database and Systematic Review of Otolaryngologic Adverse Events
Authors: Pak Kaitlynne Y. , Cutri Raffaello M. , Nadeem Wasiq , Kothari Dhruv , Wong Yu-Tung , Wu Arthur W. , Miller Mia E. 
Published: November 2024

Introduction
GLP-1 receptor agonists (GLP-1 RAs) have gained traction in the management of obesity. There is limited literature on the implications of GLP-1 RAs in the field of otolaryngology.

Methods
We explore the association between GLP-1 RAs with eustachian tube dysfunction (ETD) and patulous ETD (PETD) by review of cases, literature, and the FDA adverse event database (FAERS). We also performed a systematic review using the PRISMA guidelines.

Results
We present autophony and aural fullness following GLP-1 agonist use. In both cases, nasal endoscopy confirmed significant loss of tissue bulk of the anterior and posterior ET cushions. The total number of adverse events (AEs) with GLP-1 RAs was 97,237. The proportion of otologic AEs was 958 (0.99%): 515 hypoacusis, 203 vertigo, 97 deafness, 93 tinnitus, 22 ear pain, 21 motion sickness, 5 hyperacusis, 2 ear fullness, and 0 autophony. The largest number of potential ETD-related AEs occurred with dulaglutide (417). The greatest proportion of potential ETD-related AEs occurred with exenatide (1.52%) followed by semaglutide (1.17%) and liraglutide (1.16%). The systematic review using PRISMA guidelines yielded 1,490 initial articles, of which 937 were screened and 10 met the inclusion criteria. The top 3 identified otologic side effects included nasopharyngitis, sinusitis, unspecified dizziness.

Discussion
Ear complaints due to GLP-1 RAs have been reported previously. However, this is the first report of PETD associated with GLP-1 RAs. While literature on GLP-1 RAs and PETD is currently limited, the mechanism is well established as reports of PETD after rapid weight loss, especially in bariatric surgery, are well known. Given the rising use of GLP-1 RAs for weight loss, clinicians should be vigilant in screening for otolaryngologic side effects, especially PET, in this population.

Conclusion
Otolaryngologists should be aware and monitor for possible otolaryngologic side effects, particularly PETD, with GLP-1 RA use.
Abnormal spirometry in individuals with a smoking history and no known obstructive lung disease: current understanding and clinical implications
Authors: Tong Kevin , Moll Matthew , Wan Emily S. 
Published: November 2024

Purpose of review
Recent recognition of the importance of abnormal spirometry without obstruction has generated interest in its epidemiology, risk factors, longitudinal outcomes, and clinical implications.

Recent findings
Preserved ratio impaired spirometry (PRISm), defined as an forced expiratory volume in 1 s (FEV1)/ forced vital capacity (FVC) ≥0.7 with an FEV1 <80% predicted, has a high prevalence globally (2.4–16.7%) and is more common in individuals with metabolic comorbidities, smoking history, female sex, and higher BMI. PRISm is associated with increased respiratory symptoms and poor clinical outcomes such as increased all-cause mortality and cardiovascular events compared to normal spirometry. Longitudinal studies show substantial subsets of individuals with PRISm will transition to other spirometric categories, including progression to obstruction. Individuals with PRISm are heterogeneous; recent investigations have focused on subtyping PRISm based on spirometric features or pathobiologically-based phenotypes.

Summary
PRISm is a common spirometric abnormality which is robustly associated with negative outcomes. However, current knowledge gaps with respect to heterogeneity, specific etiologies, and longitudinal progression preclude the development of universal evidence-based diagnostic and management strategies. At present, clinicians are advised to focus on risk factor modification (e.g., diabetes, obesity) and the identification of actionable traits (e.g. emphysema, interstitial lung abnormalities) among patients with PRISm.
Characteristics and Readmission Risks Following Sepsis Discharges to Home
Authors: You Sang Bin , Song Jiyoun , Hsu Jesse Y. , Bowles Kathryn H. 
Published: November 2024

Objective:
To examine the characteristics and risk factors associated with 30-day readmissions, including the impact of home health care (HHC), among older sepsis survivors transitioning from hospital to home.

Research Design:
Retrospective cohort study of the Medical Information Mart for Intensive Care (MIMIC)-IV data (2008–2019), using generalized estimating equations (GEE) models adjusting for patient sociodemographic and clinical characteristics.

Subjects:
Sepsis admission episodes with in-hospital stays, aged over 65, and discharged home with or without HHC were included.

Measures:
The outcome was all-cause hospital readmission within 30 days following sepsis hospitalization. Covariates, including the primary predictor (HHC vs. Home discharges), were collected during hospital stays.

Results:
Among 9115 sepsis admissions involving 6822 patients discharged home (66.8% HHC, 33.2% Home), HHC patients, compared with those discharged without services, were older, had more comorbidities, longer hospital stays, more prior hospitalizations, more intensive care unit admissions, and higher rates of septic shock diagnoses. Despite higher illness severity in the HHC discharges, both groups had high 30-day readmission rates (30.2% HHC, 25.2% Home). GEE analyses revealed 14% higher odds of 30-day readmission for HHC discharges after adjusting for risk factors (aOR: 1.14; 95% CI: 1.02–1.27; P=0.02).

Conclusions:
HHC discharges experienced higher 30-day readmission rates than those without, indicating the need for specialized care in HHC settings for sepsis survivors due to their complex health care needs. Attention to sepsis survivors, regardless of HHC receipt, is crucial given the high readmission rates in both groups. Further research is needed to optimize postacute care/interventions for older sepsis survivors.
Posttransplant cyclophosphamide: a universal graft versus host disease prophylaxis
Authors: Bacigalupo Andrea 
Published: November 2024

Purpose of review
The purpose of this review is to outline current graft versus host disease (GvHD) prophylaxis, in the era of posttransplant cyclophosphamide (PTCY), in patients with malignant and nonmalignant hematologic disorders. The original combination of PTCY with a calcineurin inhibitor (CNI) and mycophenolate (MMF), reported from the Johns Hopkins University in Baltimore, was designed for patients receiving a graft from a donor mismatched at one haplotype, so called haploidentical donor (HAPLO). In the past decade, PTCY has been widely used in HAPLO transplants worldwide, confirming the amazing efficacy of PTCY in preventing GvHD in mismatched grafts.

Recent findings
More recently, PTCY is being tested also in grafts from human leukocyte antigen (HLA) identical related or unrelated donors. In the present review we will also answer several open questions, such as: PTCY and cardiac toxicity; PTCY dose; PTCY timing; PTCY and antithymocyte globulin (ATG); engraftment kinetics; infections; PTCY and leukemia relapse; PTCY and HLA identical grafts.

Summary
PTCY is currently one of the most effective measures to prevent GvHD, and can be customized in different transplant platforms, together with other immunosuppressive agents. There is place for improvement, and several possible modifications of PTCY dose and schedule can be tested in prospective trials.
Autologous Ovarian Tissue Transplantation: Preoperative Assessment and Preparation of the Patient
Authors: Turan Volkan , Oktem Ozgur 
Published: November 2024

ABSTRACT

Importance
Ovarian tissue cryopreservation (OTC) is an innovative and established fertility preservation method. More than 150 live births have been reported worldwide to date with the use of this strategy. OTC is one of the options to preserve fertility in prepubertal girls and for women who have time constraints and/or contraindications for ovarian stimulation for oocyte/embryo freezing before cancer treatment. The success rate of the ovarian tissue transplantation (OTT) depends on many interrelated factors. Therefore, preoperative evaluation and preparation of the candidate patients for the procedure are of paramount importance.

Objective
In this review, our aim was to provide a guide for the clinicians, which demonstrates step-by-step assessment and preparation of the patients and ovarian tissue samples for transplantation.

Evidence Acquisition
We searched for published articles in the PubMed database containing key words, such as OTT, OTC, preoperative assessment, primordial follicle density, and cancer, in the English-language literature until May 2024. We did not include abstracts or conference proceedings.

Results
OTT is still a developing method as an effective fertility preservation approach. It is essential to perform a thorough preoperative evaluation of the patient to improve the success rates of transplantation.

Conclusions and Relevance
Preoperative evaluation and preparation of women for ovarian transplantation surgery should include safety management to prevent reimplantation of malignant cells, transplanting ovarian tissue with minimum follicle loss and the decision of the best transfer site.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning Objectives
After completing this activity, the learner will be better able to explain how to manage couples before ovarian transplantation surgery; describe commonly used sites for OTT; and discuss the procedures eliminating the presence of malignant cells in ovarian tissue fragment.