bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Generalizability in Transnational Bureaucratic Influence Research: A (Modest) Proposal
Authors: Ege Jörn , Bauer Michael W , Wagner Nora 
Published: June 2019

AbstractAn impressive amount of evidence has been collected underpinning the importance of international public administrations (i.e., the secretariats of international governmental organizations) in a variety of policy areas, actor configurations, and multilevel political contexts. However, the problem of how to systematically observe and explain bureaucratic influence still lies at the core of the research puzzles that scholars presently attempt to solve. While acknowledging the achievements of recent research efforts, we argue that it is no coincidence that the results remain rather scattered and disconnected—as no consensus has been reached about how bureaucratic influence beyond nation states might be reasonably defined or reliably observed and how the individual insights gained could feed into the construction of a more general theory of bureaucratic influence in transnational governance. Based on a review of the literature, the essay describes what we see as the characteristic pitfalls of current research and presents two modest proposals on how the underlying challenges can be addressed. We first suggest defining the target of influence in terms of a particular policy and second advocate the inclusion of bureaucratic policy preferences into the influence concept. In order to help researchers to observe and compare policy influence across IPAs, we present a simple heuristic measurement scheme, which, if systematically applied, may help overcome the central ailment of recent influence studies. We demonstrate the applicability of the scheme by means of two empirical illustrations. The argument is that in the absence of a comprehensive descriptive, let alone analytical, theory of bureaucratic influence in transnational policymaking, our proposal may help to boost the accumulative potential of current research in the area.
Assessing the Impact of Music Therapy on Sensory Gating and Attention in Children With Autism: A Pilot and Feasibility Study
Authors: LaGasse A Blythe , Manning Rachel C B , Crasta Jewel E , Gavin William J , Davies Patricia L 
Published: June 2019

Abstract
Children with autism spectrum disorder (ASD) frequently demonstrate atypical processing of sensory information and deficits in attentional abilities. These deficits may impact social and academic functioning. Although music therapy has been used to address sensory and attentional needs, there are no studies including physiologic indicators of sensory processing to determine the impact of music therapy. The objective of this study was to determine the feasibility of conducting study protocols, determine the adequacy of electroencephalography (EEG) and behavioral measures in identifying attentional differences in children with ASD compared with typically developing (TD) children, and to gather preliminary evidence of intervention effects on brain responses and attention outcomes. Seven children with high functioning ASD ages 5 –12 and seven age- and gender-matched TD completed procedures measuring brain responses (EEG) and behaviors (the Test of Everyday Attention for Children). Children with ASD then completed a 35-min individual music therapy attention protocol delivered by a board-certified music therapist ten times over 5 weeks. Children with ASD completed measures of brain responses and behavior post-intervention to determine pre- to post-test differences. Consent and completion rates were 100% for children who met the study criteria. Feasibility measures indicated that measures of brain responsivity could be used to determine attentional differences between children with ASD and typical children. Initial outcome data for brain responses and behavior indicated positive trends for the impact of music therapy on selective attention skills.
Individualist and Ensemblist Approaches to the Foundations of Statistical Mechanics
Authors: Goldstein Sheldon 
Published: June 2019

Abstract
I will contrast the two main approaches to the foundations of statistical mechanics: the individualist (Boltzmannian) approach and the ensemblist approach (associated with Gibbs). I will indicate the virtues of each, and argue that the conflict between them is perhaps not as great as often imagined.
Music Therapists’ Preparation for Song Discussion: Meaning-Making With the Music
Authors: Hiller James 
Published: June 2019

AbstractSongs are powerful catalysts and resources for change processes in music psychotherapy. Not surprisingly, music therapists often invite clients to listen to recordings of popular songs. A common song listening method is song discussion, in which a therapist selects a relevant song to explore with a client or group and facilitates the listening and subsequent verbal processing. In the relevant music therapy literature, lyrics assume a primary focus (i.e., lyric analysis), and yet, the music of a song, as integrated with its lyrics, impacts both client’s and therapist’s meaning-making and is therefore crucial to take into account. The purpose of the present investigative essay is to encourage music therapists to give attention to the music of recorded songs as they plan to facilitate song discussion. Herein I present a conceptualization of recorded popular songs and consider how one makes meaning from song listening processes. I urge therapists to prepare for song discussion through careful phenomenological listening and introspective interpretation. Finally, I describe procedures of a developing model for aural song analysis and interpretation based on Bruscia’s Improvisation Assessment Profiles (IAPs) with an abbreviated example viewed through multiple theoretical perspectives.
High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus–Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis
Authors: Mboumba Bouassa Ralph-Sydney , Bélec Laurent , Gubavu Camelia , Péré Hélène , Matta Mathieu , Maka Artur , Puech Julien , Tonen Wolyec Serge , Veyer David , Gravier Anne , Hocqueloux Laurent , Prazuck Thierry 
Published: June 2019

AbstractBackgroundWe assessed the prevalence and risk factors of anal and oral high-risk (HR) human papillomavirus (HPV) infection in human immunodeficiency virus–uninfected men who have sex with men (MSM) and take preexposure prophylaxis (PrEP) in France.MethodsAnal and oral samples were screened by multiplex real-time polymerase chain reaction (Anyplex II HPV 28; Seegene) for HPV DNA.ResultsA total of 61 unvaccinated MSM (mean age, 36.1 years) were enrolled. Anal HPV and HR-HPV prevalences were 93.4% and 81.9%, respectively, and oral HPV and HR-HPV prevalences, 33.9% and 19.6%, respectively. HR-HPV type 33 was the most detected genotype, in both anal and oral samples. Among MSM, 68.8% carried ≥1 anal HPV type targeted by the 9-valent Gardasil-9 vaccine; all oral HPV-positive samples carried ≥1 strain included in the vaccine. Condomless receptive anal intercourse and history of anal gonorrhea were the main factors associated with increased risk for anal HPV infection (adjusted odds ratio, 10.4) and anal infection with multiple HR-HPV genotypes (5.77), respectively. Conversely, having had &lt;10 partners in the last 12 months was associated with decreased risk for anal carriage of both multiple HPV (adjusted odds ratio, 0.19) and HR-HPV (0.17) types.ConclusionFrench MSM using PrEP are at high risk for both anal and oral carriage of HR-HPV that could lead to HPV-related cancers.
Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MS
Authors: Sun Rui , Hunter Christie , Chen Chen , Ge Weigang , Morrice Nick , Liang Shuang , Yuan Chunhui , Zhang Qiushi , Cai Xue , Yu Xiaoyan , Chen Lirong , Dai Shaozheng , Luan Zhongzhi , Aebersold Ruedi , Zhu Yi , Guo Tiannan 
Published: June 2019

ABSTRACTWe report and evaluated a microflow, single-shot, short gradient SWATH MS method intended to accelerate the discovery and verification of protein biomarkers in clinical specimens. The method uses 15-min gradient microflow-LC peptide separation, an optimized SWATH MS window configuration and OpenSWATH software for data analysis.We applied the method to a cohort 204 of FFPE prostate tissue samples from 58 prostate cancer patients and 10 prostatic hyperplasia patients. Altogether we identified 27,976 proteotypic peptides and 4,043 SwissProt proteins from these 204 samples. Compared to a reference SWATH method with 2-hour gradient the accelerated method consumed only 27% instrument time, quantified 80% proteins and showed reduced batch effects. 3,800 proteins were quantified by both methods in two different instruments with relatively high consistency (r = 0.77). 75 proteins detected by the accelerated method with differential abundance between clinical groups were selected for further validation. A shortlist of 134 selected peptide precursors from the 75 proteins were analyzed using MRM-HR, exhibiting high quantitative consistency with the 15-min SWATH method (r = 0.89) in the same sample set. We further verified the capacity of these 75 proteins in separating benign and malignant tissues (AUC = 0.99) in an independent prostate cancer cohort (n=154).Overall our data show that the single-shot short gradient microflow-LC SWATH MS method achieved about 4-fold acceleration of data acquisition with reduced batch effect and a moderate level of protein attrition compared to a standard SWATH acquisition method. Finally, the results showed comparable ability to separate clinical groups.
A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes
Authors: Chang Seungwoo , Naiman Karel , Thrall Elizabeth S. , Kath James E. , Jergic Slobodan , Dixon Nicholas , Fuchs Robert P. , Loparo Joseph J 
Published: June 2019

AbstractDNA lesions stall the replisome and proper resolution of these obstructions is critical for genome stability. Replisomes can directly replicate past a lesion by error-prone translesion synthesis. Alternatively, replisomes can reprime DNA synthesis downstream of the lesion, creating a single-stranded DNA gap that is repaired primarily in an error-free, homology-directed manner. Here we demonstrate how structural changes within the bacterial replisome determine the resolution pathway of lesion-stalled replisomes. This pathway selection is controlled by a dynamic interaction between the proofreading subunit of the replicative polymerase and the processivity clamp, which sets a kinetic barrier to restrict access of TLS polymerases to the primer/template junction. Failure of TLS polymerases to overcome this barrier leads to repriming, which competes kinetically with TLS. Our results demonstrate that independent of its exonuclease activity, the proofreading subunit of the replisome acts as a gatekeeper and influences replication fidelity during the resolution of lesion-stalled replisomes.
H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis
Authors: Poleshko Andrey , Smith Cheryl L. , Nguyen Son C. , Sivaramakrishnan Priya , Murray John Isaac , Lakadamyali Melike , Joyce Eric F. , Jain Rajan , Epstein Jonathan A. 
Published: June 2019

AbstractCell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the parent. Lamina-associated domains (LADs) are regions of repressive heterochromatin positioned at the nuclear periphery that vary by cell type and contribute to cell-specific gene expression and identity. Here we show that histone 3 lysine 9 dimethylation (H3K9me2) is an evolutionarily conserved, specific mark of nuclear peripheral heterochromatin and that it is retained through mitosis. During mitosis, phosphorylation of histone 3 serine 10 temporarily shields the H3K9me2 mark allowing for dissociation of chromatin from the nuclear lamina. Using high-resolution 3D immuno-oligoFISH, we demonstrate that H3K9me2-enriched genomic regions, which are positioned at the nuclear lamina in interphase cells prior to mitosis, re-associate with the forming nuclear lamina before mitotic exit. The H3K9me2 modification of peripheral heterochromatin ensures that positional information is safeguarded through cell division such that individual LADs are re-established at the nuclear periphery in daughter nuclei. Thus, H3K9me2 acts as a 3D architectural mitotic guidepost. Our data establish a mechanism for epigenetic memory and inheritance of spatial organization of the genome.
Evaluation of supply chain coordination index in context to Industry 4.0 environment
Authors: Singh Rajesh Kumar , Kumar Pravin , Chand Mahesh 
Published: June 2019

PurposeToday, most of the manufacturing systems are changing very fast in terms of the adoption of new technologies. New technologies being implemented are Internet of Things, cyber physical systems, cloud computing, Big Data analytics and information and communication technologies. Most of the organizations in the value chain are implementing these technologies at the individual level rather than across the whole supply chain. It makes the supply chain less coordinated and causes suboptimal utilization of resources. For efficient and optimal use of modern technologies, supply chains should be highly coordinated. The purpose of this paper is to illustrate an approach for determining the index to quantify coordination in the supply chain.Design/methodology/approachFrom the literature review, total 32 factors have been identified. These factors are further clubbed into six clusters for evaluation of the coordination index. The graph theoretic approach has been used for evaluating the coordination index of a supply chain of an Indian organization.FindingsThis study has illustrated a comprehensive approach to quantify coordination of a supply chains for effective benchmarking of the supply chain performance in the Industry 4.0 era. Presently, it is observed that top management is giving more focus on organizational issues such as lean organization structure, organization culture and responsiveness factors for improving coordination in the supply chain rather than on Industry 4.0 technologies.Originality/valueThis framework can also be used for comparison, ranking and analysis of coordination issues in different supply chains in the era of Industry 4.0. Organizations can use this approach for benchmarking purpose also to improve different supply chain processes for meeting dynamic market requirements.
Bridges the crowd: rim chain framework
Authors: Li Pengze , Zhang Ran , Liu Lei , Cui Lizhen , Li Qingzhong , Zhou Guangpeng 
Published: June 2019

Purpose
Science of the Crowd is a new paradigm. The research on the relationship between provision and requirement arising from the behavior of the crowd under the interconnected environment is a promising topic. This paper aims at studying a new type of interconnected architecture.

Design/methodology/approach
This study is a pioneer work on the establishment of a new type of interconnected architecture – rim chain. The rim chain aims at supporting prompt matching between provision and requirements.

Findings
The analytical results suggest that requirements can be fulfilled in accordance with six degrees of separation. In other words, the matching between the requirements and provision takes place with six hops in the rim chain framework.

Originality/value
Knowledge graph is used to implement the rim chain.
Trade openness and sectoral growth in developing countries: some new insights
Authors: Tahir Muhammad , Mazhar Tooba , Afridi Muhammad Asim 
Published: June 2019

Purpose
The trade–growth nexus has been researched during the past few decades. However, the impact of trade openness on different sectors of the economy is not well explored. The purpose of the current study is to focus on developing countries to examine the impact of trade openness on three main sectors: industrial, service and agricultural.

Design/methodology/approach
The study applied econometric techniques that control unobserved heterogeneity and endogeneity to obtain robust and reliable results.

Findings
The results revealed that trade openness impacts different sectors differently. Trade openness positively impacts agriculture and industrial sectors, whereas it negatively affects the service sector. A similar trend is observed with regard to employment as it affects service sector negatively and creates a positive impact on other sectors, namely, agriculture and industrial sectors. Furthermore, it was found that human capital has a negative effect on all sectors, whereas financial development has positive effects on service and industrial sectors and negative effect on agriculture sector. The results are robust because of the method of estimation and the addition of some relevant variables.

Practical implications
The policymakers should focus on trade in agricultural and industrial sectors and should discourage trade in the service sector.

Originality/value
This study has examined the impact of trade openness on sectoral growth by focusing on the developing world, which is an under-researched area in the literature.
Does level of CPA firm assurance affect investing decisions?
Authors: Schneider Arnold 
Published: June 2019

Purpose
The purpose of this paper is to examine whether the level of assurance associated with financial statements affects individual investing decisions.

Design/methodology/approach
A between-subjects behavioral experiment is used with a control condition and three treatment conditions involving different levels of auditor assurance.

Findings
As the level of assurance progresses from none to compilation to review to audit, investors’ perceptions of risk associated with the investment decrease. However, the type of certified public accounting (CPA) firm association did not seem to influence the amounts that individuals were willing to invest.

Research limitations/implications
The results for the investment scenario in this paper cannot necessarily be generalized to other types of investment scenarios. Also, individuals often obtain more information about an investment prospect than what appeared in this study’s questionnaire. Another limitation is that this study did not have economic incentives such as suffering financial losses from poor investing decisions.

Practical implications
Findings about risk assessments suggest that companies might be willing to pay more for greater levels of CPA firm assurance, but the results pertaining to amounts invested suggest that companies need not consider incurring additional costs to obtain more assurance.

Originality/value
No prior study has unambiguously examined the effects of compilations, reviews and audits on investing decisions. This study explores this issue by conducting an experiment whereby investing judgments are compared across groups who received information about one of four levels of auditor assurance.
Stimulating new business creation through system dynamics education
Authors: Costanza Francesca 
Published: June 2019

Purpose
The international community recognizes the role of entrepreneurship education in fostering economic growth and sustainable development. However, preparing the next generation of entrepreneurs is not an easy task, since today’s complexity requires the creation of skills and capabilities for which the traditional programs reveal their inadequacy. Some scholars remark how entrepreneurship education and entrepreneurial intention are not necessarily related and, in line with policy makers’ concerns, call for educational programs more routed in financial skills’ enhancement. The purpose of this paper is to explore the potential of system dynamics (SD) for entrepreneurial education, investigating the relationships between financial and entrepreneurial skills’ formation and business development.

Design/methodology/approach
The paper introduces the main elements of SD, describes literature streams of SD applications fitting the entrepreneurial education spheres and proposes an SD’ insight model based on selected literature and declined in terms of stock-and-flow and causal loop structures.

Findings
The study provides a causal model capturing the links between the processes of entrepreneurial skill formation and firms’ start-ups and closures. Such model introduces a double effect of financial literacy on entrepreneurial orientation and locates the contribution of simulated entrepreneurial decisions in formal and informal educational contexts.

Originality/value
The paper displays how SD can contribute to entrepreneurship and presents an original causal model highlighting the accumulation of financial and non-financial skills through education and experience, their impact on business development and the usefulness of SD methodology for skill achievement.
Economic freedom variables endogenous to business cycles
Authors: Murphy Ryan H. 
Published: June 2019

PurposeA large empirical literature has found positive effects of economic freedom on economic outcomes, such as output and per capita growth. However, several variables in the index are very likely to decline in conjunction with recessions. The purpose of this paper is to determine whether, in the absence of these variable, whether the positive relationship between economic freedom and economic output remains.Design/methodology/approachThis paper makes use of a dynamic panel to compare the performance of economic freedom with and without variables endogenous to business cycles, which pertain to levels of government spending, rates of inflation, government borrowing and interest rates.FindingsTwo specifications fall in their statistical significance from the 1 to the 10 per cent level when variables relating to inflation are omitted. The worst case considered finds one specification size of the effect is still 66.3 per cent of the effect size of the standard measure of economic freedom.Practical implicationsThese findings are consistent with this kind of endogeneity being a minor problem with the data set when imperfect identification strategies are used, but the issue should be strongly considered when business cycles are pertinent to a research question that makes use of economic freedom data.Originality/valueThis paper contributes to the small literature focused on the robustness of the effect of economic freedom on output, while raising a specific concern that has not yet been explicitly addressed.