bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestão da aquisição e dos estoques de medicamentos:estudo de caso no Hospital Universitário de Brasília (HUB)
Authors: Costa Carolina Dorneles Florêncio , Guarnieri Patricia 
Published: June 2018

A profissionalização da logística, principalmente no que tange às compras e administração de estoques, pode ser uma das formas para otimizar recursos na administração hospitalar. O objetivo deste artigo é analisar a gestão de estoques e aquisição de medicamentos do Hospital Universitário de Brasília (HUB) sob o enfoque logístico. Foi realizada uma pesquisa aplicada, descritiva, com abordagem qualitativa, cujo procedimento técnico foi o estudo de caso, a unidade de análise foi a Farmácia Hospitalar do HUB. A coleta de dados ocorreu por meio de entrevistas, análise documental e observação direta. A análise de dados baseou-se na análise categorial temática. Constatou-se que as principais dificuldades referem-se à falta de integração entre os departamentos e às limitações de software de gerenciamento de compras e estoques. Ademais, o cunho público da instituição impede o relacionamento colaborativo com fornecedores e é calcado por restrições orçamentárias que prejudicam a prestação de serviços. The professionalization of logistics, especially in relation to purchasing and inventory management, can be one of the ways to generate the resources otimization in hospital administration. The objective of this article is to analyze stock management and medication acquisition at the Hospital Universitário de Brasília (HUB), under logistics perspective. For this purpose, it was carried out an applied, descriptive research, with qualitative approach. The technical procedure was the case study and the unit of analysis was the Hospital Pharmacy of the HUB. The data collection took place through interviews, documentary analysis and direct observation. The data analysis was based on categorical thematic analysis. As main results we can detach that the main difficulties are related to the lack of integration between departments and the limitations of purchasing and inventory management software. In addition, the public nature of the institution prevents the collaborative relationship with suppliers and is limited by budget constraints that hinder the provision of services.
Vestes e Espaço: um estudo simbólico no Tribunal de Contas do estado do Espírito Santo
Authors: Mothé Thiago , Chaves Adller Moreira 
Published: June 2018

O presente estudo observou aspectos simbólicos no Tribunal de Contas do Estado do Espírito Santo (TCE-ES), através das vestimentas dos colaboradores e o espaço organizacional. Esses aspectos simbólicos demonstram algumas das características da identidade da organização. Seguindo o estudo de Pardini, Gonçalves e Kilimnik (2008) os indivíduos dentro do TCE-ES, através das vestimentas transmitem uma serie de signos e significações que constitui a identidade da organização, como por exemplo a posição hierárquica de cada um deles dentro do TCE-ES. Além disso, esse trabalho também destacou a forma que o espaço organizacional foi idealizado e construído, transmitindo os valores organizacionais para os indivíduos da organização e de fora dela, conforme estudo de Fischer (2010). No espaço organizacional do TCE-ES ficou claro para os pesquisadores a transmissão do valor organizacional “Ética e Transparência” e condição hierárquica dos setores da organização. The present study observed symbolic aspects in the Court of Audit of the State of Espírito Santo (TCE-ES), through employee dress and organizational space. These symbolic aspects demonstrate some of the characteristics of the organization's identity. Following the study of Pardini, Gonçalves and Kilimnik (2008), individuals within the TCE-ES, through the garments transmit a series of signs and meanings that constitutes the identity of the organization, such as the hierarchical position of each of them within the TCE -ES. In addition, this work also highlighted the way that organizational space was idealized and constructed, transmitting the organizational values to the individuals of the organization and from outside it, according to Fischer's study (2010). In the organizational space of the TCE-ES it was clear to the researchers the transmission of the organizational value "Ethics and Transparency" and hierarchical condition of the sectors of the organization.
Методичні підходи в обліковому відображенні торговельних знижок
Authors: Kulynych Miroslavа 
Published: June 2018

У статті розглянуто економічну сутність знижок як частини маркетингової політики ціноутворення, визначено основну мету надання знижок. Здійснено аналіз й оцінку методичних підходів торговельних знижок, виходячи з природи їх виникнення. Обґрунтовано необхідність упровадження аналітичних рахунків доходів, які деталізують операції реалізації товарів із наданням знижок.Досліджено способи удосконалення обліку знижок на підприємствах торгівлі та запропоновано для конкретизації бухгалтерської інформації відкриття субрахунків за видами діяльності підприємства.
Proposal of a novel CHF correlation for PWR under low pressure conditions based on stepwise regression method
Authors: Yin Y. , Fu X. , Zhu Y. , Pang B. 
Published: June 2018

Abstract
Constrained by limited experimental data, development of CHF correlation for PWR fuel assemblies under transient and accidental conditions at low pressure levels (2–10 MPa) is a typical statistical problem with small sample amounts, but simultaneously has requirements of high prediction accuracy. In this study, stepwise regression method was used to develop a new CHF correlation for application in PWR under low pressure conditions. First, several essential thermal-hydraulic parameters which might influence CHF were selected based on consensus characteristics of DNB phenomenon. With stepwise regression, the form and coefficients of the proposed CHF correlation were optimized in a dynamic manner. Compared to currently available CHF correlations, represented by the Westinghouse W-3 correlation, the CHF correlation obtained by stepwise regression has a much simpler form and matches also well with the experimental data.
The Separation of AHF from Fibrinogen. II
Authors: van Creveld S , Veder H. A , Pascha C. N 
Published: June 2018

SummaryA number of experiments, aimed at a greater yield of human AHF in the chromatographic separation of fibrinogen and AHF, are reported. The experiments were conducted with both anion- and cation exchangers on a basis of cellulose, and at different pH’s. Good results were obtained with ECTEOLA-cellulose, although for therapeutical purposes a somewhat greater yield would be preferable and for the determination of the properties and constitution of AHF the preparations are not pure enough. Further work is in progress.
Action du Chlorure Mercurique sur la Rétraction du Caillot
Authors: Dotreppe J , Bounameaux Y 
Published: June 2018

Résumé1. Le chlorure mercurique bloque la rétraction du caillot à la concentration de 4 · KT4 M.2. Cystéine et glutathion s’opposent à l’action du chlorure mercurique.3. L’absence de rétraction du caillot en présence d’HgCl2 est due a une inhibition de la métamorphose visqueuse des plaquettes.4. La signification de ces faits discutée du point de vue de l’hémostase.
Individualized Learning Plan (ILP) Is an Effective Tool in Assessing Achievement of Otology-related Subcompetency Milestones
Authors: Svrakic Maja , Bent John P. 
Published: June 2018

Objective:
To investigate the individualized learning plan (ILP) as a tool in assessment of residents’ milestone achievements as they pertain to Otology subcompetencies: Chronic Ear Disease, Pediatric Otitis Media, and Hearing Loss.

Study Design:
Prospective study.

Methods:
Twenty otolaryngology residents were instructed to use an ILP and identify six milestones from three otology-related subcompetencies to focus on during the course of a 3-month rotation. They were also asked to plan out specific activities which would help them achieve these milestones, to specify whether or not they successfully achieved them, by what instructional or learning methods and to identify any barriers. The completed ILPs were reviewed by a faculty member.

Main Outcome Measures:
The effectiveness of the ILP was assessed by response compliance rate, corroboration of self-reported milestone achievement with faculty evaluations and the ability to set attainable milestones.

Results:
There was 95% compliance in using an ILP to achieve milestones. Self-reported milestone scores corresponded to the faculty evaluations in a large majority (89.6%) of patients, and tended to be underestimated by the residents. Out of 114 total milestones identified, 44 (38.6%) were not achieved, with particular overestimation in the use of independent study as a learning method.

Conclusion:
The ILP is an effective tool in measuring residents’ achievement of otology-related milestones, and could possibly be used to supplement or replace faculty assessment. The ILP provides valuable information on barriers to achieving milestones and informs trainees on how to set attainable goals as they pertain to patient care and medical knowledge in otology.
Hyperlipidemia and Nonalcoholic Steatohepatitis Predispose to Hepatocellular Carcinoma Development Without Cirrhosis
Authors: Phan Jennifer , Ng Vivian , Sheinbaum Alan , French Sam , Choi Gina , El Kabany Mohamed , Durazo Francisco , Saab Sammy , Tong Myron , Busuttil Ronald , Han Steven-Huy 
Published: June 2018

Background:
Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies. With the exception of chronic hepatitis B (CHB), other etiologies of chronic liver disease require progression to cirrhosis before HCC development. Case reports have described HCC in noncirrhotic patients with hepatitis C (HCV) and nonalcoholic fatty liver disease.

Goal:
The aim of this study was to determine the prevalence of patients without cirrhosis and CHB who developed HCC among a large cohort of HCC patients and to identify independent variables that are associated with no cirrhosis among patients with HCC.

Study:
From 2005 to 2015, hepatobiliary cancer patients seen in our liver cancer and liver transplant clinics were evaluated. Patients were included if above18 years old and had histologically confirmed HCC from liver biopsy, resection specimen, or explanted livers. Patients with CHB, non-HCC tumors, or missing paired tumor and nontumor liver histology were excluded. Demographic information, pertinent laboratory values, and comorbid conditions were recorded. Potential predictors were evaluated using both backward stepwise logistic regression model and classification tree model.

Results:
Of the 1927 patients screened, 545 HCC patients (411 transplanted, 43 resected, 74 transarterial chemoembolization/radiofrequency ablation, 17 untreated) included, 29 (5.3%) patients had no cirrhosis histologically. Eleven patients had HCV, 3 had alcoholic liver disease, 3 had nonalcoholic fatty liver, and 12 had cryptogenic liver disease. Logistic regression models show that patients with hyperlipidemia and elevated serum alanine aminotransferase are more likely to develop HCC without cirrhosis (odds ratio, 1.73 and 0.40; P<0.05).

Conclusions:
This large cohort, histology-confirmed case-controlled study shows that patients with nonalcoholic fatty liver disease and hyperlipidemia with elevated serum alanine aminotransferase (most likely nonalcoholic steatohepatitis) are significantly associated with the development of HCC in the absence of cirrhosis.
Improvement of the Legislation of Ukraine as to the Provision of the Protection of Banking in the Conditions of European Integration
Authors: KLOCHKO Alyona M. , KURILO Nikolai P. , ZAPARA Svetlana I. , ARISTOVA Irina V. , LOGVINENKO Mykola I. 
Published: June 2018

Euro-integration course of Ukraine has caused an intensive development of its banking sphere. The inconsistency between the possible legislative consolidation of criminal responsibility for socially dangerous acts in the banking sector and the objective needs of society in such protection becomes more and more obviousis in Ukraine. The processes of ‘clearing’ the banking system from financial institutions that are insolvent along with the positive results have led to an increase in the level of criminalization of the banking sector. Abuses aimed at taking possession of money from creditors and borrowers of banking institutions have become widespread. External threats to the stable functioning of the banking sector are combined with internal misconduct of unscrupulous bank managers, officials and persons related to the banks. Approaches to legislative regulation of suspicious banking transactions and to identify their real volumes must be improved. The measures aimed at reducing of the level of criminalization of the banking sphere by establishing criminal liability of managers and persons connected with the bank for unlawful acts in the banking sector must be taken. The certain issues of legal regulation of banking activity in Ukraine on criminal legal level are considered. The provisions of international law on these matters are analyzed and the main ways to optimize Ukranian criminal legislation to ensure the safety of banking activity are suggested. It turns out that the need for criminal legal protection of banking is conditoned by an increase in the public danger of these acts at the present stage of the functioning of society. This need is also confirmed by the crisis in the financial and banking spheres of the state, the need to eliminate the gaps in the current legislation on banking safety and the changes that took place in the banking sector of Ukraine in the context of increased integration with the EU.
Long story short: an introduction to the short-term and longterm Six Sigma quality and its importance in laboratory medicine for the management of extra-analytical processes
Authors: Ialongo Cristiano , Bernardini Sergio 
Published: June 2018

AbstractThere is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes. These concepts are still not widespread and applied in the field of laboratory medicine although they are of fundamental importance to exploit the full potential of this methodology. This paper reviews the Six Sigma quality concepts and shows how they originated from Shewhart’s control charts, in respect of which they are not an alternative but a completion. It also discusses the dynamic nature of process and how it arises, concerning particularly the long-term dynamic mean variation, and explains why this leads to the fundamental distinction of quality we previously mentioned.
Improvements of interfacial friction and heat transfer models for rectangular narrow channel reflood simulation based on RELAP5
Authors: Zeng W. , Yu H. , Sun Y. 
Published: June 2018

Abstract
Plate fuel assembly is widely used in reactor cores due to benefits of the narrow rectangular channels. Compared with rod assembly, the heat transfer area and power density can be increased in narrow rectangular channel, where little researches on post-CHF thermal-hydraulic characteristics have been done. Once the loss of coolant accident happens, post-CHF thermal-hydraulic characteristics are important for accident mitigation. This paper mainly evaluates the corresponding reflood models in RELAP5/MOD3 code. Combined with the post-CHF thermal-hydraulic characteristics in the narrow channel, interfacial friction model and post-CHF heat transfer models are modified. According to the comparison results with Saxena reflood experiments, conclusions can be obtained that the original RELAP5/MOD3 code overestimates quench front velocity and heat transfer in the film boiling region. The results from the code with new models agree better with the experimental data.
Flexible and Electrically Tunable Plasmons in Graphene–Mica Heterostructures
Authors: Hu Hai , Guo Xiangdong , Hu Debo , Sun Zhipei , Yang Xiaoxia , Dai Qing 
Published: June 2018

AbstractFlexible plasmonic devices with electrical tunability are of great interest for diverse applications, such as flexible metamaterials, waveguide transformation optics, and wearable sensors. However, the traditional flexible metal–polymer plasmonic structures suffer from a lack of electrical tunability. Here the first flexible, electrically tunable, and strain‐independent plasmons based on graphene–mica heterostructures are experimentally demonstrated. The resonance frequency, strength, quality factor, electrical tunability, and lifetime of graphene plasmons exhibit no visible change at bending radius down to 1 mm and after 1000 bending cycles at a radius of 3 mm. The plasmon‐enhanced infrared spectroscopy detection of chemicals is also demonstrated to be unaffected in the flexible graphene–mica heterostructures. The results provide the basis for the design of flexible active nanophotonic devices such as plasmonic waveguides, resonators, sensors, and modulators.
Intrinsic and Extrinsic Motives Support Adults’ Regular Physical Activity Maintenance
Authors: Geller Karly , Renneke Kate , Custer Sarah , Tigue Grace 
Published: June 2018

AbstractMotives for physical activity were compared between adults who either successfully or unsuccessfully maintained regular physical activity over the last 10 years. Adults age 28–45 (N=721) completed an online survey, reporting their current physical activity levels and self-determination theory (SDT) motives, as well as their physical activity levels at least 10 years prior. With participants’ current and retrospective reports of their physical activity, four sample subgroups were created, including maintainers, improvers, decliners, and sedentary. ANOVA analyses were used to examine differences in motives between physical activity maintenance groups. Those who successfully maintained regular physical activity (maintainers) reported higher intrinsic and extrinsic motives compared to those who were not regularly active (P<0.05). Interestingly, maintainers reported similar physical activity motives compared to those who reported increased physical activity over time. Among the current sample and consistent with theory, motives for physical activity significantly influenced participants’ long-term maintenance of regular physical activity. Future interventions should consider these constructs to promote sustained physical activity.
Defects in and Variability of the Thromboplastic System in Horse Plasma
Authors: Ollendorff Preben 
Published: June 2018

SummaryAmong 35 apparently normal horses, without any sign of hemorrhagic diathesis, which were tested with the thrombin generation test, 11 horses showed defects in the plasma thromboplastic system. The coagulation defects were inconstant and 3 horses showed transition from one thromboplastic defect to another.This study was supported by a grant to Dr. Tage Astrup from the Josiah Macy Jr. Foundation, New York.
Die Thrombininaktivierung als Enzymprozeß
Authors: Gerendás M 
Published: June 2018

Zusammenfassung1. Zur Inaktivierung des Thrombins ist die gleichzeitige Anwesenheit folgender Faktoren notwendig: Die bei 50-bis 60%iger Ammoniumsulfatsättigung fällbare Albuminfraktion des Serums, Heparin und die anorganischen Salze des Serums.2. Die reaktionskinetischen Untersuchungen beweisen, daß im Prozeß der Thrombinaktivierung das Thrombin als Reaktionskomponente, das Heparin jedoch als Katalysator eine Rolle spielt.3. Die Aktivierungsenergie der Thrombininaktivierung wird durch Heparin vermindert, durch Bindung desselben an Toluidinblau erhöht.4. Die Erhöhung der Heparinkonzentration vergrößert nur die Geschwindigkeit der Thrombininaktivierung, die Menge des verschwundenen Thrombins und das endgültige Gleichgewicht des Prozesses bleiben unverändert.5. Die Thrombininaktivierung hat ein pH-Optimum bei 8,0 und ein Temperaturoptimum bei 35 bis 37° C.6. Die besprochenen Untersuchungsergebnisse beweisen unsere Annahme, daß die Thrombininaktivierung ein enzymatischer Vorgang ist, wobei das Heparin als prosthetische Gruppe des Enzymsystems teilnimmt.
Behaviour of the Antithrombin Time After Extracorporeal Circulation of Blood
Authors: Thies H. A 
Published: June 2018

SummaryThe effect on antithrombin time of equal quantities of heparin and of protamine sulfate, varies from individual to individual. There are differences in both the duration and intensity of effect. An antithrombin time which is extremely prolonged by large amounts of heparin can be restored to normal only for a few hours by protamine sulfate. When the heart-lung machine is used, the first dose of protamine sulfate, measured in mg, should exceed the total amount of heparin, also measured in mg, by at least 50—100 mg. The total amount of heparin includes both that given to the patient and that added to the blood in the heart-lung machine. If the antithrombin time has not returned to normal two minutes after the protamine sulfate injection, a second dose of 100 mg is required. For at least 24 hours after the operation the antithrombin time is measured every 1—2 hours and these determinations indicate whether further protamine sulfate is necessary. Neither fresh nor preserved blood has any influence on the heparin effect.If these new findings are taken into consideration, post-operative hemorrhage, resultant from the addition of herapin, during cardiac operations with use of the heart-lung machine is avoidable. We shall report later on the behaviour of the thromboplastin time, the recalcification time, fibrinogen and thrombelastograms.
Assessment of the Dual Role of Clumping Factor A in S. Aureus Adhesion to Endothelium in Absence and Presence of Plasma
Authors: Claes Jorien , Ditkowski Bartosz , Liesenborghs Laurens , Veloso Tiago , Entenza Jose , Moreillon Philippe , Vanassche Thomas , Verhamme Peter , Hoylaerts Marc , Heying Ruth 
Published: June 2018

AbstractAdhesion of Staphylococcus aureus to endothelial cells (ECs) is paramount in infective endocarditis. Bacterial proteins such as clumping factor A (ClfA) and fibronectin binding protein A (FnbpA) mediate adhesion to EC surface molecules and (sub)endothelial matrix proteins including fibrinogen (Fg), fibrin, fibronectin (Fn) and von Willebrand factor (vWF). We studied the influence of shear flow and plasma on the binding of ClfA and FnbpA (including its sub-domains A, A16+, ABC, CD) to coverslip-coated vWF, Fg/fibrin, Fn or confluent ECs, making use of Lactococcus lactis, expressing these adhesins heterologously. Global adherence profiles were similar in static and flow conditions. In the absence of plasma, L. lactis-clfA binding to Fg increased with shear forces, whereas binding to fibrin did not. The degree of adhesion of L. lactis-fnbpA to EC-bound Fn and of L. lactis-clfA to EC-bound Fg, furthermore, was similar to that of L. lactis-clfA to coated vWF domain A1, in the presence of vWF-binding protein (vWbp). Yet, in plasma, L. lactis-clfA adherence to activated EC-vWF/vWbp dropped over 10 minutes by 80% due to vWF-hydrolysis by a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 and that of L. lactis-fnbpA likewise by > 70% compared to the adhesion in absence of plasma. In contrast, plasma Fg supported high L. lactis-clfA binding to resting and activated ECs. Or, in plasma S. aureus adhesion to active endothelium occurs mainly via two complementary pathways: a rapid but short-lived vWF/vWbp pathway and a stable integrin-coupled Fg-pathway. Hence, the pharmacological inhibition of ClfA-Fg interactions may constitute a valuable additive treatment in infective endocarditis.