bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female-Specific Role of Progranulin to Suppress Bone Formation
Authors: Wang Liping , Roth Theresa , Nakamura Mary C , Nissenson Robert A 
Published: June 2019

Abstract
Progranulin (PGRN) is best known as a glial protein for which deficiency leads to the most common inherited form of frontotemporal dementia. Recently, PGRN has been found to be an adipokine associated with diet-induced obesity and insulin resistance. Therefore, PGRN may have homeostatic effects on bone because PGRN is reported to promote the differentiation of bone-resorbing osteoclasts. We investigated the actions of PGRN on bone using PGRN gene (Grn) knockout (KO) mice and transgenic mice with PGRN mutation and surprisingly found that loss of PGRN prevented the bone loss in female mice induced by aging and estrogen deficiency, whereas it had no effect on male bones during aging. Strikingly, bone formation was increased in female (but not male) PGRN KO mice. We also found that loss of PGRN inhibited bone resorption and osteoclastogenesis in both male and female mice and promoted the production of osteogenic factors in osteoclast lineage cells. These results indicate that PGRN serves to uncouple bone turnover in female mice by promoting bone resorption and suppressing bone formation. Furthermore, we demonstrated that microglial cells/macrophages, but not adipocytes, are an important source of PGRN in producing negative skeletal effects in females. Targeting PGRN production by microglial cells/macrophage-lineage cells may provide a therapeutic approach for the treatment of osteoporosis in females.
Dermatoglyphical impressions are different between children and adolescents with normal weight, overweight and obesity: a cross-sectional study
Authors: Alberti Adriano , Kupek Emil , Comim Clarissa Martinelli , Rossoni Carina , Ruiz Reyes Myrna Alicia , Aparecida De Jesus Josiane , Grigollo Leoberto Ricardo , Becker da Silva Bruna , Duarte dos Santos Ubirajara , Souza Renan , Fin Gracielle , Baretta Elisabeth , Nodari Júnior Rudy José 
Published: June 2019

Background: Obesity is a health condition that causes a great impact on public health. The aim of this study was to determine the association between dermatoglyphic characteristics and excessive weight in children and adolescents aged 10 to 19 years in the center-west region of Santa Catarina, Brazil. Methods: The sample comprised of 2,172 children and adolescents aged 10 to 19 years old of both sexes and from public and private teaching networks. Results: The results suggested a predictive marker of obesity, with a greater number of lines in left hand finger two (Mesql2) and a higher frequency of the whorl pattern in participants of a healthy weight, while the overweight group had a higher frequency of the radial loop pattern and the obese group had a higher frequency of the ulnar loop pattern. Conclusion: It was concluded that there may be different dermatoglyphic characteristics depending on the nutritional status of children and adolescents.
Unconventional Methods in Voynich Manuscript Analysis
Authors: Zelinka Ivan , Zmeskal Oldrich , Windsor Leah , Cai Zhiqiang 
Published: June 2019

This paper discusses the possible use of unconventional algorithms on analysis and categorization of the unknown text, including documents written in unknown languages. Scholars have identied about ten famous manuscripts, mostly encrypted or written in the unknown language. The most famous is the Voynich manuscript, an illustrated codex hand-written in an unknown language or writing system. Using carbon-dating methods, the researchers determined its age as the early 15th century (between 1404-1438). Many professional and amateur cryptographers have studied the Voynich manuscript, and none has deciphered its meaning as yet, including American and British code-breakers and cryptologists. While there exist many hypotheses about the meaning and structure of the document, they have yet to be conrmed empirically. In this paper, we discuss two dierent kinds of unconventional approaches for how to handle manuscripts with unidentied writing systems and determine whether its properties are characterized by a natural language, or is only historical fake text.
Machine Learning Blunts the Needle of Advanced SQL Injections
Authors: Volkova Marina , Chmelar Petr , Sobotka Lukas 
Published: June 2019

SQL injection is one of the most popular and serious information security threats. By exploiting database vulnerabilities, attackers may get access to sensitive data or enable compromised computers to conduct further network attacks. Our research is focused on applying machine learning approaches for identication of injection characteristics in the HTTP query string. We compare results from Rule-based Intrusion Detection System, Support Vector Machines, Multilayer Perceptron, Neural Network with Dropout layers, and Deep Sequential Models (Long Short-Term Memory, and Gated Recurrent Units) using multiple string analysis, bag-of-word techniques, and word embedding for query string vectorization. Results proved benets of applying machine learning approach for detection malicious pattern in HTTP query string.
Halkla İlişkiler mi Kurumsal İletişim mi? Akademiden Uygulamaya Kavram Tartışmaları
Authors: ÖKSÜZ Burcu , GÖRPE Serra 
Published: June 2019

Bu çalışmanın amacı, ülkemizde halkla ilişkiler ve kurumsal iletişim arasındaki kavram tartışmalarını akademisyen ve uygulayıcı bakış açısıyla ortaya koyarak, ilgili mevcut literatür ve uygulamaya katkı sağlamaktır. Bu kapsamda İstanbul ve İzmir şehirlerinde çalışan ve çeşitli sektörleri temsil eden halkla ilişkiler-kurumsal iletişim uygulayıcılarıyla ve üniversitelerde görev yapan akademisyenlerle yarı yapılandırılmış görüşmeler yapılmıştır. Çalışmada halkla ilişkiler ve kurumsal iletişim kavramlarının nasıl değerlendirildiği, farklılıkların ve benzerliklerin ne olduğu, söz konusu kavramların nasıl tanımlandığı, hangi kavramın tercih edildiği, başarının nasıl tanımlandığı ve başarıyı etkileyen faktörler açısından veriler elde edilmiştir. Araştırmaya katılan uygulayıcıların tamamı kurumsal iletişim kavramını tercih etmektedirler. Bu tercihin nedenleri arasında kurumsal iletişimi daha kapsayıcı olarak görmeleri, işletme işlevine daha yakın olması ve üst yönetimden daha fazla destek görmesi yer almaktadır. Bunların yanı sıra halkla ilişkilerin tarihinden gelen olumsuzluklar da kurumsal iletişimin tercih edilmesine neden olmaktadır. Ancak akademisyenler, kurumsal iletişimi uygulayıcılar kadar tercih etmemektedir. Halkla ilişkiler kavramını tercih eden akademisyenler, bu tercihin nedenlerini halkla ilişkiler kavramının “kamu”yu içermesi ve paydaşlarını ekonomik birim olarak görmemesi olarak açıklamaktadır. Çoğu katılımcı, uygulamalara bakıldığında iki kavram arasında belirgin bir farktan söz edememektedir. Genel olarak kurumsal iletişim ve halkla ilişkilerde başarı benzer şekilde açıklanmıştır. Uygulayıcıların benzer niteliklere sahip olması gerektiğinden söz edilmiş ancak bazı katılımcılar, kurumsal iletişim uygulayıcılarının işletme nosyonuna daha fazla hâkim olması gerektiğini vurgulamışlardır. Çalışma halkla ilişkiler eğitimi açısından da değerlendirilmiştir
Colorimetric Detection of Hg(II) Ion Using Silver Nanoparticles Capped with 3-Hydroxybenzoic Acid
Authors: Gusrizal Gusrizal , Alimuddin Andi Hairil , Sapar Ajuk , Ridwan Rizki Noviani , Santosa Sri Juari 
Published: June 2019

In this paper, we report for the first time thesimple method for detection of Hg(II) ion in anaqueousmedium using silver nanoparticles capped with 3-hydroxybenzoic acid. Silver nanoparticles capped with 3-hydroxybenzoic acid were preparedby reduction of the silver ion with 3-hydroxybenzoic acid and without surface functionalization. The formation of silver nanoparticles was characterized by a UV-Visible spectrophotometer. The yellowcolloid of prepared silver nanoparticles capped with 3-hydroxybenzoic acid showed a surface plasmon resonance peak at 420 nm. The ability of silver nanoparticles capped with 3-hydroxybenzoic acid in detection was tested by doing a reaction with several metal ions individually(Na(I), K(I), Cu(II), Zn(II), Ca(II), Mg(II), Hg(II), Mn(II), Ni(II), Pb(II), and Co(II)). It was foundthat silver nanoparticles capped with 3-hydroxybenzoic acid highly selective toHg(II) and then the prepared silver nanoparticles were developedfor detection of Hg(II) ion. Addition of 1 mL Hg(II) ion into 4mL the as-preparedsilver nanoparticles reducedthe peak of surface plasmon resonance spectra, andthe reduction of peak intensity was proportional to the concentration of Hg(II) ion. A goodlinear relationship (R2= 0.998) between absorbance at 420 nm and concentrationof Hg(II) over the range 1.0x10-3to 5.5x10-3M was obtained. Silver nanoparticles capped with 3-hydroxybenzoic acid were highly sensitive to Hg (II) ion with the detection limit down to 4.7x10-5M. Application the method to the real water sample showed the excellentresult with recovery ranged from 98 to 101%. The proposed method was found to be useful forthe colorimetric detection of Hg(II) ion in an aqueousmedium.
Environmental surveillance of norovirus and hepatitis A virus in raw oysters at seafood retails in Sinaloa, Mexico: detection of GII.P13 norovirus genotype
Authors: Villicaña Claudia , Amarillas Luis , Cota-Álvarez América , León-Félix Josefina , Gómez-Gil Bruno 
Published: June 2019

Abstract
Background
Norovirus (NoV) and hepatitis A virus (HAV) have emerged as the leading agents of non-bacterial acute gastroenteritis and hepatitis, respectively, primarily associated to food-borne outbreaks followed by the consumption of seafood. In Mexico, little is known about the molecular epidemiology of NoV and HAV, and a few studies have reported their presence in aquatic environments. In Sinaloa, the pleasure oyster (Crassostrea cortiziensis, Hertlein) is one of the main species consumed at seafood retails; however, information about the presence and genetic diversity of NoV and HAV is lacking. The aim of the present study was to investigate the prevalence and molecular diversity of NoV and HAV in raw pleasure oysters expended at seafood retails in Sinaloa, Mexico.

Methods
A total of 68 samples were collected at several seafood retails at four periods: Period 1 (October-November, 2010); Period 2 (December 2010-January 2011); Period 3 (March-April, 2011); and Period 4 (May, 2011). These oyster samples were tested for the presence of NoV and HAV by retrotranscription (RT)-nested PCR and RT-PCR, respectively. Enumeration of fecal coliforms was also conducted. In addition, an analysis of Binary Logistic Regression (BLR) was performed to determine a possible correlation of these enteric viruses with the presence of fecal coliforms and environmental temperature.

Results
Overall, NoV was detected in 57.3% of the 68 samples showing the highest occurrence (11/13) during Period 1 (October-November, 2010). No HAV-positive samples were detected. Fecal coliforms were more frequently detected (16/20) on Period 4 (May, 2011). A significant negative correlation between NoV and fecal coliforms was observed. A total of 28 sequences were obtained from NoV amplicons and surprisingly, phylogenetic analysis showed that all NoV sequences obtained from oysters belonged to GII.P13 genotype.

Conclusions
The results indicated that raw oysters expended at seafood retails are potential sources of human infection due to the presence of NoV, which interestingly were represented only by GII.P13 genotype. This is the first report confirming the presence of GII.P13 in Mexico, which may contribute with the better understanding of NoV genetic diversity and epidemiology.
Effects of paternal alcoholism on the psycho-behavioral outcomes of children: systematic review and meta-analysis
Authors: Mahesh PKB , Leung Janni , Senanayake S.J. , Kumarapeli Vindya , Ferdinando Ruwan , McLaughlin Deirdre 
Published: June 2019

Abstract
Introduction:
Documented literature includes mixed interpretations of the impact of paternal alcoholism on psycho-behavioral well-being in children. A systematic review and a meta-analysis would facilitate the accurate establishment of this association.

Aim:
To evaluate the effects of paternal alcoholism on the psycho-behavioral well-being of children by a systematic review with a meta-analysis and a narrative review component

Methods: This PROPERO registered review (CRD42018114754) was conducted by reviewing searching literature in MEDLINE, EMBASE and PsycINFO databases. Twenty nine articles out of 16398 were selected for data extraction after three selection rounds. Thirteen were included in the meta-analyses for four numerical outcomes and two categorical outcomes. Meta-analysis outcomes included; internalizing behavior, externalizing behavior, depression and anxiety. Heterogeneity, risk of biases and the quality of evidence were assessed. Sensitivity analysis was done by re-analyzing with random-model assumption following the fixed model assumption. Furthermore re-analysis with standardized mean difference was done following the analysis with mean difference. Rev Man (version 5.3) software and “GRADEproGDT” online applications were used. Summary of Findings Tables were prepared. A narrative review was done with studies and sub-groups not included in the meta-analysis, under five identified themes: depression and mood disorders; self-perceived mental health problems and personality; aggression; ADHD and other problems.

Results: With meta-analysis, all four numerical outcomes for demonstrated significant mean differences (MD) with higher values in the group with paternal alcoholism. “Low” level was assigned as the GRADE certainty. For the anxiety when it is regarded as a categorical outcome, the resulting relative effect was significant (OR=2.18, 95% CI= 2.03 to 2.33) with “Moderate” certainty. In sensitivity analysis, associations of similar directions were observed. Narrative review reflected other negative psycho-behavioral consequences of children associated with paternal alcoholism, falling under the five identified themes.

Conclusions:
Robust findings were observed for the positive associations of paternal alcoholism with the selected psycho-behavioral pathologies of children in the meta-analysis. The narrative review further demonstrated negative implications of paternal alcoholism on five identified thematic areas.
Impact of a Rapid Molecular Diagnostic Test for the Identification of Bloodstream Infections in Intensive Care Units: Experience from a Developing Country
Authors: Salcedo Sergio Reyes , Hernández-Gómez Cristhian , Pallares Christian , Salcedo Soraya , Valderrama-Beltrán Sandra , Ordóñez Karen , Correa Adriana , Villegas María V. 
Published: June 2019

Abstract
Background

Rapid diagnostics have been demonstrated to be a crucial component of antimicrobial stewardship programs. However, most of the studies have been conducted in developed countries where health-care facilities have 24/7 microbiology laboratories. Colombia is an example of a developing country with limited resources in which hospitals are not able to implement a 24/7 model and samples are usually processed once a day. Here, we compared time to pathogen identification by QuickFISH® with conventional cultures and its effect on decrease duration of therapy in critical patients.

Methods

A multicenter, ambispective cohort study was conducted in four high-complexity ICU hospitals between 2016-2017. Adult patients admitted to the ICU with positive blood cultures and signs of systemic inflammatory response syndrome were included in the study. Patients with bloodstream infections identified by either QuickFISH® or PNA FISH® were observed prospectively and compared with those patients with bloodstream infections identified by conventional blood cultures alone who were analyzed retrospectively. Duration of treatment, time to final reports and survival rate were compared between the two groups. Additionally, the performance of the molecular test was compared with the conventional blood culture.

Results

A total of 153 patients were included in the study. Among them, 72 (47%) were in the QuickFISH® / PNA FISH® group and 81 (53%) in the conventional blood culture group. 87% of the patients had a bacteria identified (n=133) and 13% (n=20) a candida. QuickFISH® / PNA FISH® had 96% (89%-100%) concordance with blood culture. The microbiological identification report was 26 hours faster in the QuickFISH® group than in blood culture group (29 hours vs. 55 hours; p = 0.0001). The duration of antimicrobial therapy was 3.2 days shorter in the QuickFISH® group compared to the BC group (13.7 days vs. 16.9 days; p = 0.026).

Conclusions

Molecular diagnostic methods such as QuickFISH® reduce the time to final reports as well as the duration of therapy in ICU patients with bloodstream infections. Despite having more impact in 24/7 laboratories, QuickFISH® methods may be a promising diagnostic tool in developing countries if incorporated with antimicrobial stewardship programs.
Pulsed electric field disinfection treatment of Fusarium oxysporum in nutrient solution
Authors: Zhong Chongshan , Guan Xinxing , Fan Zhe , Song Weitang , Chen Ran , Wang Yi , Sun Xiaoyan , He Shouxing 
Published: June 2019

Abstract
The disinfection of recirculating nutrient solution is essential to avoid disasters due to the dispersal of pathogens in closed soilless culture systems. This work presents the development of a new technique to perform disinfection, based on pulsed electric field (PEF) treatment. Hoagland solution inoculated with Fusarium oxysporum was selected as the specimen to verify the effectiveness of PEF treatment. The results indicate that PEF deactivated most Fusarium oxysporum in nutrient solution within a few seconds with the maximum disinfection efficiency achieved being 99.84%. The disinfection efficiency became higher with the extending of treatment time or the increase of PEF strength, while the initial microbial density was proven to play no role. Temperature rise indicates that PEF treatment played the dominant role in the process of disinfection. The energy efficiency depends mainly on treatment time and electric field intensity. The optimal operating conditions were found to be: treatment time less than 10 seconds and electric field strength around 5 kV/cm. This investigation implies that, in the future, PEF treatment has the potential to be applied to disinfect nutrient solution.
An electrode-assisted anaerobic digestion process for the production of high-quality biogas
Authors: Yanuka-Golub K. , Baransi-Karkaby K. , Szczupak A. , Reshef L. , Rishpon J. , Shechter R. , Gophna U. , Sabbah I. 
Published: June 2019

Abstract
Biogas is a sustainable, renewable energy source generated from organic waste degradation during anaerobic digestion (AD). AD is applied for treating different types of wastewater, mostly containing high organic load. However, AD practice is still limited due to the low quality of the produced biogas. Upgrading biogas to natural gas quality (&gt;90% CH4) is essential for broad applications. Here, an innovative bio-electrochemically assisted AD process was developed, combining wastewater treatment and biogas upgrading. This process was based on a microbial electrolysis cell (MEC) that produced hydrogen from wastewater at a relatively high efficiency, followed by high-rate anaerobic systems for completing biodegradation of organic matter and an in situ bio-methanation process. Results showed that CH4 production yield was substantially improved upon coupling of the MEC with the AD system. Interestingly, CH4 production yield increase was most notable once circulation between AD and MEC was applied, while current density was not markedly affected by the circulation rates. The microbial community analysis confirmed that the MEC enhanced hydrogen production, leading to the enrichment of hydrogenotrophic methanogens. Thus, directing soluble hydrogen from the MEC to AD is plausible, and has great potential for biogas upgrading, avoiding the need for direct hydrogen harvesting.
Two-stage air stripping combined with hydrolysis acidification process for coal gasification wastewater pretreatment
Authors: Chen Xiurong , Sun Xiaoli , Wang Xiaoxiao , Xu Peng , Yang Chenchen , Lu Quanling , Wang Shanshan 
Published: June 2019

Abstract
Coal gasification wastewater is mainly from gas washing, condensation and purification processes in the gas furnace with high NH3-N (nitrogen in water in the form of free ammonia (NH3) and ammonium ion (NH4+)), TN (total nitrogen) and refractory organics content, which will inhibit the subsequent biological treatment. The ‘air stripping – hydrolysis acidification – air stripping’ process was proposed as the pretreatment for coal gasification wastewater to improve the biodegradability and nitrogen removal, which could reduce the subsequent biological treatment load. The first-stage air stripping process before hydrolysis acidification could achieve a significant removal of NH3-N (97.0%) and volatile phenol (70.0%), reducing the corresponding toxicity on hydrolysis acidification. The group with air stripping had more abundant microbial communities and a more effective organic degradation performance in hydrolysis acidification than that without air stripping. The second-stage air stripping removed NH3-N released from hydrolysis acidification, and significantly reduced the TN concentration in effluent. The whole process achieved a TN removal from 2,000 ± 100 mg/L to 160 ± 80 mg/L, and a total phenols removal from 700 ± 50 mg/L to 80 ±20 mg/L.
Efeitos dos exercícios de controle neuromuscular da cintura escapular para jogadores de basquete em cadeira de rodas
Authors: Zaleski Tatiane Daniele Preczewski , Jantara Simone Renata Galli , Agostini Géssica Del , Guedes Janesca Mansur 
Published: June 2019

Introdução: O treino de controle neuromuscular é importante na reabilitação e na prática esportiva. Objetivo: Verificar os efeitos dos exercícios de controle neuromuscular da cintura escapular para jogadores de basquete em cadeira de rodas. Materiais e métodos: A pesquisa caracteriza-se por um estudo longitudinal do tipo descritivo-exploratório, de caráter quantitativo. A amostra foi composta por nove homens, atletas cadeirantes praticantes de basquete, com idade média de 37,78 anos, portadores de lesão medular (67%), amputação (22%) e poliomielite (11%). Os exercícios de controle neuromuscular foram realizados duas vezes por semana, por 14 semanas, em um total de 25 sessões. Para análise dos dados foi utilizado o teste t-student pareado e o nível de significância foi p≤0,05. Foi realizado teste de agilidade e potência pré e pós-intervenção. Resultados: No teste de agilidade verificouse uma diferença estatisticamente significativa (p
Folkhälsans seniorboende och aktivt åldrande – BoAktiv-studien
Authors: Lahti Anna-Maria , Simonsen Nina , Seppänen Marjaana , Finne Maria , Sarvimäki Anneli , Von Bonsdorff Mikaela 
Published: June 2019

Syftet med denna enkät-studien är att utreda samband mellan aktivt åldrande, gemenskap och delaktighet hos åldringar som bor i seniorhus. Utöver detta syftar forskningen till att producera beskrivande information om hälsa och välmående hos åldringar i seniorhus. Målgruppen var självständigt boende i Folkhälsans seniorhus.
Största delen av respondenterna var över 80 år gamla, kvinnor, svenskspråkiga och bodde ensamma. De mest aktiva seniorerna hade bättre hälsorelaterad livskvalitet samt mindre symptom av depression, och deltog mer i verksamheten i seniorhuset och hade en högre känsla av samhörighet. Respondenternas känsla av samhörighet korrelerade positivt med psykiskt välmående, högre vitalitet och energinivå.
Enligt resultaten kan man konstatera att aktivt åldrande, gemenskap och delaktighet är i samband hos invånarna i seniorhus. Det är viktigt att sträva till att öka möjligheterna till att vara aktiv och delaktig i seniorhus, vilket även kan öka känslan av gemenskap. Seniorhus har utmärkta möjligheter att mångsidigt stöda den äldres välmående.