bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Menstrual Health Status and Evolution through Mobile Apps for Fertility Awareness
Authors: Symul Laura , Wac Katarzyna , Hillard Paula , Salathé Marcel 
Published: August 2018

AbstractFor most women of reproductive age, assessing menstrual health and fertility typically involves regular visits to a gynecologist or another clinician. While these evaluations provide critical information on an individual’s reproductive health status, they typically rely on memory-based self-reports, and the results are rarely, if ever, assessed at the population level. In recent years, mobile apps for menstrual tracking have become very popular, allowing us to evaluate the reliability and tracking frequency of millions of self-observations, thereby providing an unparalleled view, both in detail and scale, on menstrual health and its evolution for large populations. In particular, we were interested in exploring the tracking behavior of the app users and their overall observation patterns in an effort to understand if they were consistent with previous small-scale medical studies. We also investigated whether their precision allowed the detection and estimation of ovulation timing, which is critical for reproductive and menstrual health. Retrospective self-observation data were acquired from two mobile apps dedicated to the application of the sympto-thermal fertility awareness method, resulting in a dataset of more than 30 million days of observations from over 2.7 million cycles. The analysis of the data showed that up to 40% of the cycles in which users were seeking pregnancy had recordings every single day. With a modeling approach using Hidden Markov Models to describe the collected data and estimate ovulation timing, it was found that follicular phases average duration and range were larger than previously reported, with only 24% of ovulations occurring at days 14 to 15, while the luteal phase duration and range were in line with previous reports, although short luteal phases (10 days or less) were more frequently observed (in up to 20% of cycles). The digital epidemiology approach presented here can help to lead to a better understanding of menstrual health and its connection to women’s health overall, which has historically been severely understudied.
Exogenous calcium ions enhance patulin adsorption capability of Saccharomyces cerevisiae
Authors: Luo Ying , Liu Xiaojiao , Han Yanqing , Li Jianke 
Published: August 2018

AbstractPatulin contamination is a severe issue that restricts the development of the global fruit processing industry. Yeast adsorbs patulin more effectively than other microbial adsorbents, and this adsorption process mainly depends on the function of the cell wall. Additionally, exogenous calcium ions aid in yeast cell wall formation according to reports. Therefore, in the present study, the effect of exogenous calcium concentrations on the cell wall structure and the patulin adsorption capability was studied. We showed that the ability of the yeast to adsorb patulin was strengthened with an increase in exogenous calcium concentrations between 1×10-4 - 1×10-2 mol/L. Moreover, yeast cell wall thickness, β-1,3-glucan content and the activities of the key catalytic enzymes β-1,3-glucanase and β-1,3-glycosyl transferase were all increased within this range. The results indicated that exogenous calcium activates key enzymes and that these enzymes are crucial for cell wall network formation and patulin adsorption capability.ImportanceThe present work illuminates that the exogenous calcium ions could determine the insoluble network structure by regulating key enzyme activities under certain concentrations, thus indirectly influencing the yeast cell patulin adsorption capability. It could enhance patulin adsorption capability of yeast walls and successfully apply to fruit juice industry.
Modeling circRNAs expression pattern with integrated sequence and epigenetic features identifies H3K79me2 as regulators for circRNAs expression
Authors: Chen Jia-Bin , Dong Shan-Shan , Yao Shi , Duan Yuan-Yuan , Hu Wei-Xin , Chen Hao , Wang Nai-Ning , Hao Ruo-Han , Guo Ming-Rui , Zhang Yu-Jie , Rong Yu , Chen Yi-Xiao , Thynn Hlaing Nwe , Zhou Fu-Ling , Guo Yan , Yang Tie-Lin 
Published: August 2018

AbstractCircular RNAs (circRNAs) are an abundant class of noncoding RNAs with widespread, cell/tissue specific pattern. Because of their involvement in the pathogenesis of multiple disease, they are receiving increasing attention. Previous work suggested that epigenetic features might be related to circRNA expression. However, current algorithms for circRNAs prediction neglect these features, leading to constant results across different cells.Here we built a machine learning framework named CIRCScan, to predict expression status and expression levels of circRNAs in various cell lines based on sequence and epigenetic features. Both expression status and expression levels can be accurately predicted by different groups of features. For expression status, the top features were similar in different cells. However, the top features for predicting expression levels were different in different cells. Noteworthy, the importance of H3K79me2 ranked high in predicting both circRNAs expression status and levels across different cells, indicating its important role in regulating circRNAs expression. Further validation experiment in K562 confirmed that knock down of H3K79me2 did result in reduction of circRNA production.Our study offers new insights into the regulation of circRNAs by incorporating epigenetic features in prediction models in different cellular contexts.
Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the periglomerular cells of the mouse main olfactory bulb
Authors: Homma Ryota , Lv Xiaohua , Sato Tokiharu , Imamura Fumiaki , Zeng Shaoqun , Nagayama Shin 
Published: August 2018

AbstractOdor information is transmitted from olfactory sensory neurons to principal neurons at the glomeruli of the olfactory bulb. The intraglomerular neuronal circuit also includes hundreds of GABAergic interneurons referred to as periglomerular (PG) cells. Stimulus selectivity is well correlated among PG cells that are associated with the same glomerulus, consistent with their highly homogeneous sensory inputs. However, much less is known about the temporal aspects of their activity, including the temporal coordination of their odor-evoked responses. As many PG cells within a glomerular module respond to the same stimulus, the extent to which their activity is temporally aligned will affect the temporal profile of their population inhibitory inputs. Using random-access high-speed two-photon microscopy, we recorded the odor-evoked calcium transients of mouse PG cells and compared the onset latency and rise time among neurons putatively associated with the same and different glomeruli. Whereas the overall onset latencies of odor-evoked transients were distributed across a ~150 ms time window, those from cells putatively associated with the same glomerulus were confined to a much narrower window of several tens of milliseconds. This result suggests that onset latency primarily depends on the associated glomerulus. We also observed glomerular specificity in the rise time. The glomerulus-specific temporal pattern of odor-evoked activity implies that the temporal patterns of inhibitory inputs are unique to individual glomerulus–odor pairs, which may contribute to efficient shaping of the temporal pattern of activity in the principal neurons.
Bacterial cohesion predicts spatial distribution in the larval zebrafish intestine
Authors: Schlomann Brandon H. , Wiles Travis J. , Wall Elena S. , Guillemin Karen , Parthasarathy Raghuveer 
Published: August 2018

AbstractAre there general biophysical relationships governing the spatial organization of the gut microbiome? Despite growing realization that spatial structure is important for population stability, inter-bacterial competition, and host functions, it is unclear in any animal gut whether such structure is subject to predictive, unifying rules, or if it results from contextual, species-specific behaviors. To explore this, we used light sheet fluorescence microscopy to conduct a high-resolution comparative study of bacterial distribution patterns throughout the entire intestinal volume of live, larval zebrafish. Fluorescently tagged strains of seven bacterial symbionts, representing six different species native to zebrafish, were each separately mono-associated with animals that had been raised initially germ-free. The strains showed large differences in both cohesion—the degree to which they auto-aggregate—and spatial distribution. We uncovered a striking correlation between each strain’s mean position and its cohesion, whether quantified as the fraction of cells existing as planktonic individuals, the average aggregate size, or the total number of aggregates. Moreover, these correlations held within species as well; aggregates of different sizes localized as predicted from the pan-species observations. Together, our findings indicate that bacteria within the zebrafish intestine are subject to generic processes that organize populations by their cohesive properties. The likely drivers of this relationship, peristaltic fluid flow, tubular anatomy, and bacterial growth and aggregation kinetics, are common throughout animals. We therefore suggest that the framework introduced here, of biophysical links between bacterial cohesion and spatial organization, should be useful for directing explorations in other host-microbe systems, formulating detailed models that can quantitatively map onto experimental data, and developing new tools that manipulate cohesion to engineer microbiome function.
Lsm12 mediates Pol·q deubiquitination to help Saccharomyces cerevisiae resist oxidative stress
Authors: Yao Rui , Shi Liujia , Wu Chengjin , Qiao Weihua , Liu Liming , Wu Jing 
Published: August 2018

ABSTRACTIn Saccharomyces cerevisiae, the Y-family DNA polymerase η (Polη) regulates genome stability in response to different forms of environmental stress by translesion DNA synthesis. To elucidate the role of Polη in oxidative stress-induced DNA damage, we deleted or overexpressed the corresponding gene RAD30, and used transcriptome analysis to screen the potential genes associated with RAD30 to respond to DNA damage. Under 2 mM H2O2, deletion of RAD30 resulted in a 2.2-fold decrease in survival and a 2.8-fold increase in DNA damage, whereas overexpression of RAD30 increased survival and decreased DNA damage by 1.2- and 1.4-fold, respectively, compared with that of the wild-type strain. Transcriptome and phenotypic analysis identified Lsm12 as a main factor involved in oxidative stress-induced DNA damage. Deleting LSM12 caused growth defects while its overexpression enhanced cell growth under 2 mM H2O2. This effect was due to the physical interaction of Lsm12 with the UBZ domain of Polη to enhance Polη deubiquitination through Ubp3, and consequently promote Polη recruitment. Overall, these findings demonstrate that Lsm12 is a novel regulator mediating Polη deubiquitination to promote its recruitment under oxidative stress. Furthermore, this study provides a potential strategy to maintain the genome stability of industrial strains during fermentation.IMPORTANCEPolη was shown to be critical for cell growth in the yeast Saccharomyces cerevisiae, and deletion of its corresponding gene RAD30 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2. Furthermore, we found that Lsm12 physically interacts with Polη and promotes Polη deubiquitination and recruitment. Overall, these findings indicate Lsm12 as a novel regulator mediating Polη deubiquitination that regulates its recruitment in response to DNA damage induced by oxidative stress.
A decision support system of green inventory-routing problem
Authors: Liu Gia-Shie , Lin Kuo-Ping 
Published: August 2018

Purpose
The purpose of this paper is to develop a decision support system to consider geographic information, logistics information and greenhouse gas (GHG) emission information to solve the proposed green inventory routing problem (GIRP) for a specific Taiwan publishing logistics firm.

Design/methodology/approach
A GIRP mathematical model is first constructed to help this specific publishing logistics firm to approximate to the optimal distribution system design. Next, two modified Heuristic-Tabu combination methods that combine savings approach, 2-opt and 1-1 λ-interchange heuristic approach with two modified Tabu search methods are developed to determine the optimum solution.

Findings
Several examples are given to illustrate the optimum total inventory routing cost, the optimum delivery routes, the economic order quantities, the optimum service levels, the reorder points, the optimum common review interval and the optimum maximum inventory levels of all convenience stores in these designed routes. Sensitivity analyses are conducted based on the parameters including truck loading capacity, inventory carrying cost percentages, unit shortage costs, unit ordering costs and unit transport costs to support optimal distribution system design regarding the total inventory routing cost and GHG emission level.

Originality/value
The most important finding is that GIRP model with reordering point inventory control policy should be applied for the first replenishment and delivery run and GIRP model with periodic review inventory control policy should be conducted for the remaining replenishment and delivery runs based on overall simulation results. The other very important finding concerning the global warming issue can help decision makers of GIRP distribution system to select the appropriate type of truck to deliver products to all retail stores located in the planned optimal delivery routes depending on GHG emission consumptions.
SUPPLIER INNOVATION IN THE PRESENCE OF BUYER POWER
Authors: Chen Zhiqi 
Published: August 2018

AbstractThis article analyzes the impact of retailer buyer power on a supplier's incentive to conduct innovation, with a focus on the supplier's investment in product variety and quality improvement. The analysis shows that an increase in buyer power, manifested through either a weakening of the supplier's bargaining position or a strengthening of a large retailer's bargaining power, leads to greater product variety and higher quality if the elasticity of demand is not too large. Increased buyer power, manifested through a strengthening of a large retailer's bargaining position, stimulates the supplier to invest more in quality improvement.
Social exclusion of the adolescent with overweight: study of sociocentric social networks in the classroom
Authors: Arias Ramos N. , Calvo Sánchez M. D. , Fernández‐Villa T. , Ovalle Perandones M. A. , Fernández García D. , Marqués‐Sánchez P. 
Published: August 2018

SummaryBackgroundMultiple studies have shown the social consequences of suffering overweight, with social exclusion or isolation as some of the most important. In order to study the social patterns among adolescents, we have set as objectives to analyse the position of the individual within their network from a sociocentric perspective, comparing the relational pattern of the adolescents suffering from overweight with those who are normal weight.MethodThis was a cross‐sectional descriptive study using logistic regression and social network analysis. We analysed the contact patterns of 235 adolescents in 11 social networks, classifying contact into three levels of intensity: minimum, intermediate and maximum (friendship). The WHO reference was used for the variable of overweight.ResultsThe prevalence of overweight was 30.2% (25.5% overweight and 4.7% obesity). An analysis of the relational patterns of individuals with overweight showed that at the minimum contact level, they established fewer relationships and less closeness (odds ratio [OR]: 2.32; confidence interval [CI] 95%: 1.17–4.66; p‐value: 0.016). This effect was more marked in female adolescents. At intermediate contact level, they had few relationships and low prestige (OR: 3.29; CI: 95%; 1.03–10.51; p‐value: 0.045, OR: 3.18; CI: 95%; 1.00–10.04; p‐value: 0.049, respectively). At maximum contact level (friendship), female adolescents related little with other adolescents (OR: 3.78; CI: 95%; 1.07–13.32; p‐value: 0.038).ConclusionsAdolescents with overweight take up peripheral positions within their social network, choosing by themselves not to establish contact with others. Social network analysis is crucial to detect adolescents with overweight at risk of exclusion and help alleviate psychological and social deficits.
Putting the Ghost Back in the Machine: An Exploration of Somatic Dualism
Authors: Davidson Matthew 
Published: August 2018

AbstractIn this article, I explore various views on which mind–body dualism is true, but the soul is located in the body. I argue that this sort of dualism (which I call ‘somatic dualism’) once was a not‐uncommon view in the philosophy of mind. I also argue that it has the resources to reply to some of the problems thought to affect Cartesian dualism.
The status of Cuvierina spoeli Rampal, 2002 and Cuvieria oryza Benson, 1835 (Gastropoda, Pteropoda, Cuvierinidae)
Authors: JANSSEN ARIE W. 
Published: August 2018

The name Cuvierina spoeli Rampal, 2002 cannot be understood as a new replacement name (nom. nov.) for Cuvierina atlantica, as published in the unavailable name Cuvierina columnella (Rang, 1827) f. atlantica van der Spoel, 1970. The name atlantica was made available as a name of the species group in the combination Cuvierina columnella atlantica Bé, MacClintock & Currie, 1972, currently interpreted to represent the species Cuvierina atlantica. Cuvierina spoeli type material does not belong to C. atlantica, but to C. columnella of which it therefore is a junior subjective synonym. The name Cuvieria oryza Benson, 1835 was recognised to represent a senior synonym of Cuvierina urceolaris (Mörch, 1850), not a junior synonym or form of C. columnella Rang, 1827, as it was frequently interpreted by authors. The name C. oryza is here declared nomen oblitum and the name C. urceolaris, because in prevailing usage, is declared nomen protectum. The conditions of ICZN (1999, art. 23.9.1.1 and .2) are met.
CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer
Authors: Janjigian Yelena Y. , Bendell Johanna , Calvo Emiliano , Kim Joseph W. , Ascierto Paolo A. , Sharma Padmanee , Ott Patrick A. , Peltola Katriina , Jaeger Dirk , Evans Jeffry , de Braud Filippo , Chau Ian , Harbison Christopher T. , Dorange Cecile , Tschaika Marina , Le Dung T. 
Published: August 2018

Purpose Metastatic esophagogastric cancer treatments after failure of second-line chemotherapy are limited. Nivolumab demonstrated superior overall survival (OS) versus placebo in Asian patients with advanced gastric or gastroesophageal junction cancers. We assessed the safety and efficacy of nivolumab and nivolumab plus ipilimumab in Western patients with chemotherapy-refractory esophagogastric cancers. Patients and Methods Patients with locally advanced or metastatic chemotherapy–refractory gastric, esophageal, or gastroesophageal junction cancer from centers in the United States and Europe received nivolumab or nivolumab plus ipilimumab. The primary end point was objective response rate. The association of tumor programmed death-ligand 1 status with response and survival was also evaluated. Results Of 160 treated patients (59 with nivolumab 3 mg/kg, 49 with nivolumab 1 mg/kg plus ipilimumab 3 mg/kg, 52 with nivolumab 3 mg/kg plus ipilimumab 1 mg/kg), 79% had received two or more prior therapies. At the data cutoff, investigator-assessed objective response rates were 12% (95% CI, 5% to 23%), 24% (95% CI, 13% to 39%), and 8% (95% CI, 2% to 19%) in the three groups, respectively. Responses were observed regardless of tumor programmed death-ligand 1 status. With a median follow-up of 28, 24, and 22 months across the three groups, 12-month progression-free survival rates were 8%, 17%, and 10%, respectively; 12-month OS rates were 39%, 35%, and 24%, respectively. Treatment-related grade 3/4 adverse events were reported in 17%, 47%, and 27% of patients in the three groups, respectively. Conclusion Nivolumab and nivolumab plus ipilimumab demonstrated clinically meaningful antitumor activity, durable responses, encouraging long-term OS, and a manageable safety profile in patients with chemotherapy-refractory esophagogastric cancer. Phase III studies evaluating nivolumab or nivolumab plus ipilimumab in earlier lines of therapy for esophagogastric cancers are underway.
КОНЦЕПТ FAMILY (СЕМЬЯ) В РОМАНЕ М. ПЬЮЗО «КРЕСТНЫЙ ОТЕЦ»
Authors: Omarova Patimat Magomedovna , Akhmedova Zukhra Garunovna 
Published: August 2018

Цель. В статье анализируется художественный концепт FAMILY и его репрезентация в романе М. Пьюзо «Крестный отец».Методология проведения работы. Исследование проводилось с использованием контекстуального, интерпретационного и описательного методов.Результаты. Результаты работы показали, что в анализируемом романе концепт FAMILY объективируется по-разному. Содержание концепта шире содержания понятия «family» (семья), традиционно представленного в лексикографических источниках и в языковой картине мира. Помимо основных репрезентаций («семья – дом», «семья – кровные родственники»), концепт «семья» представлен в романе как организация (отдельное государство), члены организации (мафии), опора, бизнес, а также метафорическими репрезентациями «семья – империя, королевство», «семья – механизм».Область применения результатов. Результаты исследования могут быть использованы при изучении художественных концептов и способов их языковой репрезентации.
Marx na Europa do século XX | Marx in 20th Century Europe
Authors: Varela Raquel , Barros Roberto Della Santa 
Published: August 2018

Com muita frequência é possível encontrar análises sobre a história europeia do séc. XX que não passam de justificações ideológicas do tempo presente, seja a partir de pressupostos a orbitar Washington ou premissas irradiadas desde Moscou, isso para não mencionar as teses pós-modernas ou neoconservadoras. Argumentamos nesse artigo que, para retomar a iniciativa e a luta pela autodeterminação dos trabalhadores e povos europeus, é preciso, também, uma nova escrita da história europeia recente. Nada disso é possível sem levar em conta a tradição intelectual e o movimento político que tem lugar a partir do legado de Karl Marx.Palavras-chave: Marx; Europa; história social; autodeterminação. Abstract −It is often possible to find analyses of 20th-century European history that are no more than ideological justifications of the present, whether asserting assumptions from Washington or premises from Moscow, not to mention postmodern or neoconservative theses. We argue in this article that in order to resume the initiative and struggle for the self-determination of European workers and peoples, a new writing of recent European history is also required. None of this is possible without taking into account the intellectual tradition and the political movement that emerged from the legacy of Karl Marx.Keywords: Marx; Europe; social history; self-determination.