bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical perspectives on post‐induction maintenance therapy in patients with acute myeloid leukaemia in remission who are ineligible for allogeneic haematopoietic stem cell transplantation
Authors: Sweet Kendra , Cluzeau Thomas 
Published: December 2024

SummaryFor patients with acute myeloid leukaemia (AML) who achieve complete remission (CR) after induction therapy, subsequent allogeneic haematopoietic stem cell transplantation (allo‐HSCT) reduces the risk of relapse. However, not all patients are eligible, warranting effective alternative maintenance strategies. Oral azacitidine is the only non‐targeted therapy approved by both the United States (US) Food and Drug Administration and the European Medicines Agency for the maintenance or continued treatment of allo‐HSCT‐ineligible patients with AML achieving CR or CR with incomplete haematological recovery following induction chemotherapy. Midostaurin and histamine dihydrochloride are approved in Europe as maintenance therapy for AML in remission, and quizartinib is approved in the United States and Europe for the treatment and maintenance of patients with newly diagnosed FLT3‐ITD AML. Barriers to maintenance treatment include limited clinical trial data informing appropriate patient and treatment selection, patient preference, financial burden and paucity of real‐world data. This article discusses current maintenance treatment guidelines for patients with AML in remission but not proceeding to allo‐HSCT and reviews clinical trial data for agents approved for use in remission. Ongoing studies of interest and considerations for future efforts are also discussed.
Determinants of Social Dialogue in European Countries (1980–2018)
Authors: Afonso Alexandre , Kiecker Maximilian , Goulart Pedro 
Published: December 2024

ABSTRACTThis paper provides a quantitative assessment of the political and structural determinants of social dialogue in 25 European countries between 1980 and 2018 using a measure of social dialogue based on an original survey of industrial relations and social policy experts. We assess hypotheses on the role of structural (unionisation, employer organisation) and political (government partisanship, government strength) factors on the extent of cooperation between governments, trade unions and employers in public policymaking. We find a declining trend in the overall extent of social dialogue in the countries surveyed. Using panel regressions, we show that higher levels of social dialogue are more prevalent among governments where there is a balance of power between right‐wing and left‐wing parties, and thus where unions and employers can act as ‘brokers’ between left and right parties. We find no association between most structural factors (unionisation, collective bargaining coverage, employer organisation) and levels of social dialogue.
Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes
Authors: Hua Zixin , Yang Siyu , Li Jiqian , Sun Yiqi , Liao Yin , Song Siyang , Cheng Sheng , Li Zhe , Li Ze , Li Dandan , Guo Heng , Yang Hongge , Zheng Yingming , Li Xingang 
Published: December 2024

AbstractAimsTo provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF).Materials and MethodsWe conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta‐analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random‐effects models. Article quality and the certainty of the evidence were graded using A Measurement Tool to Assess Systematic Reviews (AMSTAR‐2), Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and a standardized credibility grading system.ResultsTwelve meta‐analysis studies and 122 health outcome associations with IF were identified. High‐quality evidence indicated significant associations between time‐restricted eating (TRE) and weight loss, fat mass reduction, decreased fasting insulin and glycosylated haemoglobin levels in overweight or obese adults, as well as between the 5:2 diet and reduced low‐density lipoprotein cholesterol levels. Moderate‐to‐low‐quality evidence suggested associations between modified alternate‐day fasting and improvements in body weight, lipid profile and blood pressure. Additionally, high‐to‐low‐quality evidence showed that IF regimens effectively improved liver health in non‐alcoholic fatty liver disease.ConclusionsThis umbrella review highlights IF, especially TRE, as a promising intervention for weight and metabolic health, particularly beneficial for overweight or obese adults. We also highlight the need for further extensive research to understand the long‐term effects, individualized IF plans and potential adverse effects of IF in different populations.
Inferring long‐distance movements of insects using combined hydrogen isotope and genetic analyses: A case study of the African edible bush‐cricket
Authors: Valtonen Anu , Holm Sille , Korkiatupa Eveliina , Malinga Geoffrey M. , Nakadai Ryosuke , Nyeko Philip , Roininen Heikki , Strandberg Ursula , Wassenaar Leonard I. , Pilecky Matthias 
Published: December 2024

Abstract
The degree to which individuals within populations vary in whether, how far and what direction they disperse is central in order to understand many foundational questions in ecological entomology, including factors determining population and invasion dynamics, species' ability to respond to climate change or when designing conservation strategies for threatened species.
This study combined stable hydrogen isotope analysis of nymphal and adult wing chitin with population genetic analysis of the cytochrome c oxidase subunit I (COI) gene to understand long‐distance movements of African edible bush cricket (Ruspolia differens) in East Africa.
Results revealed that at most 77% of non‐swarming adults and 85% swarming adults originated locally, that is, within a range of a few hundred kilometres. In contrast, non‐local adults captured in Uganda likely originated from Ethiopia, Kenya or South Sudan based on the H isotopic evidence. Genetic analysis revealed 150 COI haplotypes with no significant differentiation among geographic source regions and no evidence of genetic isolation by movement distance.
The observed frequent long‐distance movements, together with the historical records, which indicate that the swarm movements can be irregular in their direction, suggest that the movements represent nomadism rather than regular long‐distance migration. Our results thus provide a valuable case study of what characterizes nomadic movements in insects, which have been one of the outstanding open questions in movement ecology of animals.
Using cluster‐based permutation tests to estimate MEG/EEG onsets: How bad is it?
Authors: Rousselet Guillaume A. 
Published: December 2024

AbstractLocalising effects in space, time and other dimensions is a fundamental goal of magneto‐ and electroencephalography (EEG) research. A popular exploratory approach applies mass‐univariate statistics followed by cluster‐sum inferences, an effective way to correct for multiple comparisons while preserving high statistical power by pooling together neighbouring effects. Yet, these cluster‐based methods have an important limitation: each cluster is associated with a unique p‐value, such that there is no error control at individual timepoints, and one must be cautious about interpreting when and where effects start and end. Sassenhagen and Draschkow (2019) provided an important reminder of this limitation. They also reported results from a simulation, suggesting that onsets estimated from EEG data are both positively biased and very variable. However, the simulation lacked comparisons to other methods. Here, I report such comparisons in a new simulation, replicating the positive bias of the cluster‐sum method, but also demonstrating that it performs relatively well, in terms of bias and variability, compared to other methods that provide pointwise p‐values: two methods that control the false discovery rate and two methods that control the familywise error rate (cluster‐depth and maximum statistic methods). I also present several strategies to reduce estimation bias, including group calibration, group comparison and using binary segmentation, a simple change point detection algorithm that outperformed mass‐univariate methods in simulations. Finally, I demonstrate how to generate onset hierarchical bootstrap confidence intervals that integrate variability over trials and participants, a substantial improvement over standard group approaches that ignore measurement uncertainty.
An integrated approach to address the biodegradability of cosmetic formulations as part of a corporate sustainability strategy
Authors: Zacarias Cyro Hauaji , Paludetti Mayara Fregonezi , de Oliveira Andréia Ávila Soares , Federico Leonardo Bruno 
Published: December 2024

AbstractObjectiveThe biodegradability of organic chemicals with usual down‐the‐drain disposal in their end‐of‐life is a key parameter to be considered by industries pursuing sustainability in their new product developments. It is a property that, once improved in any formulated product portfolio, will allow for a significant reduction in the presence of its ingredients in the natural environment, with a potential reduction in the pollution‐related environmental impact after consumption. This article aimed to propose an intelligent strategy for addressing biodegradability in the cosmetics sector, with the potential to support both product claims and corporate sustainability initiatives.MethodsThe framework for achieving a portfolio biodegradability indicator is composed of three levels of assessment, the first being an ingredient level assessment, the second being an individual product biodegradability calculation (PBI—Product Biodegradability Index), and finally a third level to calculate an emission‐based, company‐wide biodegradability indicator (GBI—Global Biodegradability Index). A case study is presented and discussed in detail, as a proof of applicability of the whole framework to support new developments for an improved environmental performance. Important insights in terms of ingredients assessment criteria are also presented.ResultsA fictitious portfolio composed of two soaps (a bar and a liquid), two hair care products (shampoo and hair conditioner) and one bath oil resulted in a GBI of 92.8%. The bar soap was the main contributor for this global index, with a PBI of 98.8% and a relatively high consumption volume of 1 ton/year, which accounts for approximately 66% of the total portfolio consumption. Other products, like hair care, presented lower PBIs, but their lower mass consumption representativeness within the portfolio prevented a significant negative impact on the global index. The main strategic directions derived from the case study, to ensure a stable and high biodegradability of the consumed organic mass, were properly discussed.ConclusionThe output of this framework provided an intelligent management strategy for innovation, where reformulation efforts can be targeted at products and ingredients with the highest potential to improve the biodegradability profile of the total organic mass released to the environment from a given portfolio.
Biases in Routine Influenza Surveillance Indicators Used to Monitor Infection Incidence and Recommendations for Improvement
Authors: Eales Oliver , McCaw James M. , Shearer Freya M. 
Published: December 2024

ABSTRACTBackgroundMonitoring how the incidence of influenza infections changes over time is important for quantifying the transmission dynamics and clinical severity of influenza. Infection incidence is difficult to measure directly, and hence, other quantities which are more amenable to surveillance are used to monitor trends in infection levels, with the implicit assumption that they correlate with infection incidence.MethodsHere, we demonstrate, through mathematical reasoning using fundamental mathematical principles, the relationship between the incidence of influenza infections and three commonly reported surveillance indicators: (1) the rate per unit time of influenza‐like illness reported through sentinel healthcare sites, (2) the rate per unit time of laboratory‐confirmed influenza infections and (3) the proportion of laboratory tests positive for influenza (‘test‐positive proportion’).ResultsOur analysis suggests that none of these ubiquitously reported surveillance indicators are a reliable tool for monitoring influenza incidence. In particular, we highlight how these surveillance indicators can be heavily biassed by the following: the dynamics of circulating pathogens (other than influenza) with similar symptom profiles, changes in testing rates and differences in infection rates, symptom rates and healthcare‐seeking behaviour between age‐groups and through time. We make six practical recommendations to improve the monitoring of influenza infection incidence. The implementation of our recommendations would enable the construction of more interpretable surveillance indicator(s) for influenza from which underlying patterns of infection incidence could be readily monitored.ConclusionsThe implementation of all (or a subset) of our recommendations would greatly improve understanding of the transmission dynamics, infection burden and clinical severity of influenza, improving our ability to respond effectively to seasonal epidemics and future pandemics.
Method to characterize phase transformation kinetics at high temperature
Authors: Seymour Kevin C. , McCormack Scott J. , Ribero Daniel , Kriven Waltraud M. 
Published: December 2024

AbstractA new method is described to characterize the transformation kinetics of reconstructive systems at high temperatures using synchrotron X‐ray radiation, a quadrupole lamp furnace, and a detector capable of collecting a diffraction pattern of sufficient range in a minimal amount of time. Using this method, the activation energy for a reconstructive phase transformation in Dy2TiO5 was determined to be 149 kJ/mol. This value is more reasonable when compared with the uncertain values determined using conventional methods such as differential scanning calorimetry. In addition, the new method also provides higher quality data with improved time resolution, leading to better determination of fitted kinetic parameters.
Nurse‐Administered Screening Tools for Detecting Elder Abuse in Emergency Departments: A Scoping Review
Authors: El Hussein Mohamed , Sheehan Dawson 
Published: December 2024

ABSTRACTAimIdentify and describe nurse‐administered screening tools used in emergency departments (ED) to detect elder abuse.DesignA scoping review of literature published between 1999 and 2024 was conducted following the guidance of the Joanna Briggs Institute Manual for Evidence Synthesis and a methodological framework for scoping studies.MethodsTwo reviewers, an academic faculty member and a senior undergraduate, conducted the screening and data extraction, aiming to identify studies using a nurse‐administered screening tool in the ED to detect elder abuse.Data SourcesThe final search was conducted on 24 April 2024, using the CINAHL, MEDLINE, PsycINFO, and Cochrane Review databases.ResultsTen studies out of 145 met the inclusion criteria, identifying six screening tools that assist healthcare providers, such as nurses, in detecting elder abuse in EDs. The results were summarised and presented according to each screening tool.Implications for the ProfessionNurses in EDs are well‐positioned to identify elder abuse due to the significant time spent observing and interacting with patients. The implementation of a screening tool can support nurses in detecting elder abuse and initiating appropriate interventions.ImpactElder abuse is a widespread public health issue projected to increase continuously with the rapidly ageing population. Incorporating nurse‐administered screening tool into EDs has demonstrated practicality and usefulness in identifying elder abuse cases. Various tools exist; however, these instruments are underutilised due to limited reliability and feasibility testing, with no definitive screening tool identified as the “gold standard” for elder abuse detection. Without formal screening, elder abuse is likely to remain undetected, leaving victims vulnerable to harmful consequences. Due to the limited testing and evaluation of a reliable ED screening tool for elder abuse, future research should focus on developing and validating a new screening tool intended specifically for use by nurses in EDs.Reporting MethodThe EQUATOR guidelines for PRISMA were met.Patient or Public ContributionNo patient or public contributions.
CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients
Authors: Sedova Ksenia , Azarov Jan E. , Van Dam Peter M. , Necasova Lucie , Kukla Jan , Sramko Marek , Kryze Lukas , Kautzner Josef 
Published: December 2024

ABSTRACTIntroductionA variable proportion of non‐responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences.ObjectiveThe present study aimed to evaluate CineECG‐derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients.Methods and ResultsCineECG was used to construct the average electrical path within the cardiac anatomy from the 12‐lead ECG. CineECG and LV dP/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170 ± 17 ms; LVEF: 26 ± 5.5%) under pacing protocols with different LV lead localizations. The CineECG‐derived path directions were computed for the QRS and ST‐T intervals for the anteroposterior (Xh), interventricular (Yh), and apicobasal (Zh) axes. In a multivariate linear regression analysis with adjustment for the pacing protocol type, the ST‐T path direction Yh was independently associated with the increase in dP/dt max during CRT, [regression coefficient 639.4 (95% confidence interval: 187.9–1090.9), p = 0.006]. In ROC curve analysis, the ST‐T path direction Yh was associated with the achievement of a 10% increase in dP/dt max (AUC: 0.779, p = 0.002) with the optimal cut‐off > 0.084 (left‐to‐right direction) with sensitivity 0.67 and specificity 0.92.ConclusionThe acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.
Malformations vs. Neoplasia in the Oral Cavity: Special Emphasis on Mixed Odontogenic Tumors
Authors: Soluk‐Tekkesin Merva , Bologna‐Molina Ronell , Magliocca Kelly , van Heerden Willie , Robinson Liam , Bilodeau Elizabeth Ann , Hussaini Haizal Mohd , Adisa Akinyele Olumuyiwa , Tilakaratne Wanninayake Mudiyanselage , Li Jiang , Hunter Keith David , Gomez Ricardo Santiago 
Published: December 2024

ABSTRACTBackgroundThe terminology surrounding developmental lesions in the oral cavity is widely applied, often leading to confusion in differentiating between developmental malformations and neoplasia. Odontogenic tumor classification includes both true neoplasms and malformations which make it very complex and dynamic.Method and ConclusionIn this brief report, we will first discuss the concepts of malformations and neoplasia and then focusing on their relevance to odontogenic tumors, which impacts their classification and treatment, particularly mixed odontogenic lesions.
Lrp Family Regulator SCAB_Lrp2 Responds to the Precursor Tryptophan and Represses the Thaxtomin Biosynthesis in Streptomyces scabies
Authors: He Haoyang , Tang Lijuan , Song Mingrui , Chen Hui , Zou Youquan , Li Xueyan , Yang Endong , Wu Hang , Zhang Buchang , Liu Jing 
Published: December 2024

ABSTRACTStreptomyces scabies is a well‐researched plant pathogen belonging to the genus Streptomyces. Its virulence is linked to the production of the secondary metabolite thaxtomin A, which is tightly regulated at the transcriptional level. The leucine‐responsive regulatory protein (Lrp) family is conserved in prokaryotes and is involved in various crucial biological processes. However, the regulatory interaction between Lrp protein and pathogenic Streptomyces species remains poorly understood. This study aims to explore the role of SCAB_Lrp2 in regulating thaxtomin biosynthesis and pathogenicity, and to analyse the shared and unique features of Lrp homologues in S. scabies. We observed that SCAB_Lrp2 (SCAB_75421) showed significant homology with SCAB_Lrp, a recognised activator of thaxtomin A production in S. scabies. Our results revealed a regulatory interaction between SCAB_Lrp2 and SCAB_Lrp in terms of their targets, although SCAB_Lrp2 does not respond to the amino acid‐effectors of SCAB_Lrp. In contrast to SCAB_Lrp, deletion of SCAB_Lrp2 resulted in a notable increase in thaxtomin A production with the emergence of a hypervirulent phenotype in S. scabies. Further analysis revealed that SCAB_Lrp2 represses the transcription of the thaxtomin biosynthetic gene cluster by directly regulating the cluster‐situated regulator (CSR) gene txtR. Moreover, the precursor of thaxtomin, tryptophan, acts as an effector of SCAB_Lrp2, strengthening the repressive effect on thaxtomin biosynthesis through txtR. These findings provide new insights into the functional conservation and diversity of Lrp homologues involved in the biosynthesis of thaxtomin phytotoxins in pathogenic Streptomyces species.