bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВИБІР КІЛЬКІСНОГО СКЛАДУ ДОПОМІЖНИХ РЕЧОВИН ПРИ СТВОРЕННІ ТАБЛЕТОК ЦЕОЛІТУ ПРИРОДНОГО (КЛІНОПТИЛОЛІТУ)
Authors: Rybachuk V. D. , Ruban O. A. 
Published: June 2018

Мета роботи. Вивчити вплив кількостей допоміжних речовин на фармако-технологічні властивості таблеток цеоліту природного (кліноптилоліту) та оптимізувати склад готової лікарської форми.Матеріали і методи. Об’єкти досліджень – таблетки цеоліту природного середньої маси 0,55 г та діаметром 10 мм, отримані пресуванням із попередньою вологою грануляцією. У дослідженнях використовували цеоліт природний (кліноптилоліт) Сокирницького родовища (Закарпатська область, Україна). Для вибору фармацевтичних факторів, які суттєво впливають на об’єкт дослідження, використовували дробний факторний експеримент 23 з рівним дублюванням дослідів. Вивчено 3 кількісні фактори, взаємозв’язок між факторами та фармако-технологічними показниками таблеток виражали та інтерпретували за допомогою рівнянь регресії. У дослідах використовували сучасне обладнання. Для тестів користувалися методиками Державної фармакопеї України.Результати й обговорення. За отриманими даними встановлено, що на однорідність маси таблеток найбільшою мірою впливає концентрація зволожувача, на механічну стійкість до роздавлювання – концентрація наповнювача, на стійкість до стирання – вміст суміші лактози моногідрату з МКЦ-101 та крохмалю картопляного, а на час розпадання – вміст крохмалю картопляного. За допомогою регресійного аналізу та додаткових досліджень за схемою «крутого сходження» встановлено оптимальний склад таблеток цеоліту природного (кліноптилоліту): цеоліту природного (кліноптилоліту) –0,4 г; суміші лактози моногідрату з МКЦ-101 (1:1) –0,085 г; крохмалю картопляного –0,047 г; 7 % клейстеру крохмального картопляного –0,1 г (0,007 г сухого); кальцію стеарату –0,003 г.Висновок. Проведено дослідження з підбору кількісного вмісту допоміжних речовин для отримання таблеток цеоліту природного пресуванням із попередньою вологою грануляцією та запропоновано оптимальний склад таблеток, властивості яких відповідають діючим вимогам ДФУ.
ЕКСПЕРТНА ОЦІНКА ПРОСТАТОПРОТЕКТОРІВ ДЛЯ ФАРМАКОТЕРАПІЇ ХРОНІЧНОГО ПРОСТАТИТУ (на прикладі Івано-Франківської області)
Authors: Hromovyk B. P. , Gadyak I. V. , Trishch V. I. 
Published: June 2018

Мета роботи. Проведення експертної оцінки простатопротекторів (ПП) як лікарських засобів, що впливають на запальне ураження передміхурової залози.Матеріали і методи. Матеріалом дослідження була інформація експертної оцінки фармакотерапії (ФТ) простатиту, отримана за допомогою анкетування, яке здійснювалося за методикою О. Р. Левицької. Було проаналізовано 55 анкет від лікарів-урологів Івано-Франківської області, з них для подальшого дослідження за рівнем компетентності експертів відібрано 34 анкети (61,8 %).Результати й обговорення. Виявлено, що всі експерти повністю володіють інформацією щодо ПП. Для понад чотирьох п’ятих основним джерелом інформації є Державний формуляр лікарських засобів, для близько чотирьох п’ятих – мережа Internet, для понад половини – інструкції для медичного застосування ПП. Майже дві третини лікарів-урологів при призначенні ПП не зважають на платоспроможність хворого, понад дві п’яті з них призначають ПП після ретельного аналізу його клінічного застосування, майже всі експерти обирають ПП відповідно до стандартів лікування, майже половина з них не надає значення походженню ПП, але віддає перевагу оригінальним ПП. Усі експерти ПП торгові назви тамсулозину, силодозину, теразозину, тамсулозину і дудастериду, фінастериду віднесли до класу V і Е, тобто життєво важливих і необхідних. Омнік капс. одностайно визнаний як найбільш важливим для ФТ, ефективним, безпечним та часто призначуваним ПП. Інші два ПП із сильною узгодженістю думок експертів щодо групи V (Фокусин капс. 0,4, Омнік Окас таб.) характеризуються таким же рівнем узгодженості щодо високої ефективності, безпечності та частоти призначення. Встановлено, що необхідно звернути увагу на Простатилен-Біофарма ліофілізат 10 мг та Простатилен суп.0,03 г, які характеризуються високою узгодженістю думок експертів щодо групи D, високої ефективності і безпечності та помітною узгодженістю щодо частоти призначення.Висновки. Шляхом анкетного опитування лікарів-урологів Івано-Франківської області вивчено доступність для них інформації про сучасні ПП, особливості сприйняття ними нових ПП та рівень впливу окремих чинників на призначення ПП. Здійснено, з урахуванням компетентності експертів, оцінку важливості для ФТ ХП, ефективності, безпечності та частоти призначення ПП. Отримані результати будуть використані для оптимізації локальних та регіонального формулярів лікарських засобів в частині ФТ ХП.
Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis
Authors: Lino Marsel , Wan Mark H. , Rocca Antonio S. , Ngai David , Shobeiri Navid , Hou Guangpei , Ge Chunxi , Franceschi Renny T. , Bendeck Michelle P. 
Published: June 2018

Objective—
Vascular calcification is a common and severe complication in patients with atherosclerosis which is exacerbated by type 2 diabetes mellitus. Our laboratory recently reported that the collagen receptor discoidin domain receptor 1 (DDR1) mediates vascular calcification in atherosclerosis; however, the underlying mechanisms are unknown. During calcification, vascular smooth muscle cells transdifferentiate into osteoblast-like cells, in a process driven by the transcription factor RUNX2 (runt-related transcription factor 2). DDR1 signals via the phosphoinositide 3-kinase/Akt pathway, which is also central to insulin signaling, and upstream of RUNX2, and this led us to investigate whether DDR1 promotes vascular calcification in diabetes mellitus via this pathway.

Approach and Results—

Ddr1
+/+
; Ldlr
−/−
(single knock-out) and
Ddr1
−/−
; Ldlr
−/−
(double knock-out) mice were placed on high-fat diet for 12 weeks to induce atherosclerosis and type 2 diabetes mellitus. Von Kossa staining revealed reduced vascular calcification in the aortic arch of double knock-out compared with single knock-out mice. Immunofluorescent staining for RUNX2 was present in calcified plaques of single knock-out but not double knock-out mice. Primary vascular smooth muscle cells obtained from
Ddr1
+/+
and
Ddr1
−/−
mice were cultured in calcifying media. DDR1 deletion resulted in reduced calcification, a 74% reduction in p-Akt levels, and an 88% reduction in RUNX2 activity. Subcellular fractionation revealed a 77% reduction in nuclear RUNX2 levels in
Ddr1
−/−
vascular smooth muscle cells. DDR1 associated with phosphoinositide 3-kinase, and treatment with the inhibitor wortmannin attenuated calcification. Finally, we show that DDR1 is important to maintain the microtubule cytoskeleton which is required for the nuclear localization of RUNX2.

Conclusions—
These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling.
Keeping Up Appearances
Authors: Moretti Sebastien 
Published: June 2018

Abstract
The fact that most Southeast Asian States are not party to the main instruments pertaining to the protection of refugees has given rise to the ‘rejection of international refugee law’ theory, which has largely dominated the literature on the issues pertaining to refugees in Southeast Asia. Based on an analysis of the practices of Southeast Asian States with regard to refugees, this article argues that although they are not party to the 1951 Convention, the main countries of asylum in the region, i.e. Thailand, Malaysia and Indonesia, de facto treat differently the people they acknowledge to be in need of some sort of protection: that is, refugees. Unlike other irregular migrants, refugees are protected against non-refoulement and, to a certain extent, are also protected from detention for irregular entry into the territory of another State. In doing so, Southeast Asian States maintain a ‘fiction’ according to which they preserve sovereignty over the borders of their countries while in reality largely accepting the limitations posed by international refugee law.
The ‘Taboas geraes’ of João Teixeira Albernaz I as a Mediated Textual Object
Authors: McCarl Clayton 
Published: June 2018

Abstract
This article examines the ‘Taboas geraes da toda a navegacão’ (1630), a manuscript atlas by Portuguese cartographer João Teixeira Albernaz I (fl.1602-1649), as a textual artifact permanently altered and resignified by the additions and alterations that Spanish mariner and author Francisco de Seyxas y Lovera (c.1646-c.1705) carried out in the late seventeenth century. I examine the biographical circumstances in which Seyxas possessed the atlas and analyze his modifications of the ‘Taboas geraes’ as authorial acts with political, autobiographical and literary dimensions. I seek, as well, to identify problems that the ‘Taboas geraes’ presents for how we understand matters of authorship and textual nature surrounding this object – as well as other one-of-a-kind, mediated artefacts – examining whether existing scholarship provides an adequate framework through which to approach this situation.
A Twelver-Shīʿī Multi-Text Volume (16th through 18th century) Held in the New York Public Library (Ms New York Public Library, Arabic Manuscripts Collection, Manuscripts and Archives Division, Volume 51985A)
Authors: Schmidtke Sabine 
Published: June 2018

AbstractMs New York Public Library, Arabic Manuscripts Collection, Manuscripts and Archives Division, Volume 51985A is a heavily damaged multitext volume which comprises seven individual works: An incomplete copy of Khiḍr b. Muḥammad b. ʿAlī al-Rāzī al-Ḥablirūdī’s (d. ca. 850/1447) longer commentary on the ʿAllāma al-Ḥillī’sal-Bāb al-ḥadī ʿashar, Jāmiʿ al-durar fī sharḥ al-Bāb al-ḥādī ʿashar; several works by Ibn Abī Jumhūr al-Aḥsāʾī (d. after 906/1501), viz.Qabs al-iqtidāʾ fī sharāʾiṭ al-iftāʾ wa-l-istiftāʾ, Kāshifat al-ḥāl ʿan aḥwāl al-istidlāl, andal-Masālik al-jāmiʿiyya fī sharḥ al-Alfiyya, which were copied during the author’s lifetime; Bahāʾ al-Dīn Muḥammad b. al-Ḥusayn al-ʿĀmilī’s (“al-Shaykh al-Bahāʾī”, d. 1030/1621)Tafsīr sūrat al-fātiḥa, oral-ʿUrwa al-wuthqā; and two works by Bahāʾ al-Dīn Muḥammad b. Ḥasan al-Iṣfahānī “al-Fāḍil al-Hindī” (d. 1137/1725) which are not attested elsewhere—a commentary (ḥāshiya) on the chapter on the imamate of Saʿd al-Dīn al-Taftāzānī’s (d. 792/1390)Sharḥ al-Maqāṣid, and a commentary on theNahj al-ḥaqq wa-kashf al-ṣidqby the ʿAllāma al-Ḥillī.
Petrous Apex Pneumatization: Influence on Postoperative Cerebellopontine Angle Tumor Cerebrospinal Fluid Fistula
Authors: Shew Matthew , Muelleman Thomas , Harris Michael , Li Michael , Sykes Kevin , Staecker Hinrich , Adunka Oliver Fr , Lin James 
Published: June 2018

Objective: Multiple investigators have sought to identify risk factors for cerebrospinal fluid (CSF) leak following cerebellopontine angle (CPA) tumor resection. We evaluated whether pneumatization of the petrous apex (PA) is a risk factor for CSF fistula. Method: We conducted a retrospective chart review at 2 major tertiary academic institutions undergoing CPA tumor resection and analyzed their respective head or temporal computed tomography (CT) scans if available. Results: A total of 91 cases were identified; 51 (64%) demonstrated PA pneumatization, and a total of 17 CSF leaks were identified. We discovered higher rates of CSF leak (25.0% vs 13.7%; P = .273) and CSF rhinorrhea (15.0% vs 5.9%; P = .174) in patients with PA pneumatization compared to those without PA pneumatization. Conclusions: Isolated PA pneumatization may be a risk factor and communication pathway for CSF fistula. Further studies will need to be broadened across multiple institutions to draw any additional and stronger conclusions.
Building workforce capacity in Australia and New Zealand: a profile of psychiatrists with an interest in intellectual and developmental disability mental health
Authors: Cvejic Rachael C , Eagleson Claire , Weise Janelle , Davies Kimberley , Hopwood Malcolm , Jenkins Kym , Trollor Julian N 
Published: June 2018

Objective: To describe the characteristics of psychiatrists working in the area of intellectual and developmental disability mental health (IDDMH) across Australia and New Zealand. Methods: A secondary analysis of data collected by the Royal Australian and New Zealand College of Psychiatrists 2014 workforce survey. Characteristics of the IDDMH workforce ( n=146 psychiatrists) were compared with those of the broader psychiatry workforce ( n=1050 psychiatrists). Results: The IDDMH workforce were more likely than the broader psychiatry workforce to be working across both the public and private health sectors, be engaged in outreach work, endorse specialty practice areas pertinent to IDDMH, treat younger patients and work more clinical hours per week. Part-time status and retirement plans of the IDDMH workforce matched those of the broader psychiatry workforce. Conclusions: While some elements of the IDDMH workforce profile suggest this workforce is tailored to the needs of the population, the potential shortage of IDDMH psychiatrists highlights the need for the development of a specific training programme and pathway in this area.
A five-year retrospective study of out-of-hospital cardiac arrest in a north-east Italian urban area
Authors: Danielis Matteo , Chittaro Martina , De Monte Amato , Trillò Giulio , Durì Davide 
Published: June 2018

Background: The reporting and analysing of data of out-of-hospital cardiac arrests encourages the quality improvement of the emergency medical services. For this reason, the establishment of a sufficiently large patient database is intended to allow analysis of resuscitation treatments for out-of-hospital cardiac arrests and performances of different emergency medical services. Aims: The aim of this study was to describe the demographics, characteristics, outcomes and determinant factors of survival for patients who suffered an out-of-hospital cardiac arrest. Methods: this was a retrospective study including all out-of-hospital cardiac arrest cases treated by the emergency medical service in the district of Udine (Italy) from 1 January 2010–31 December 2014. Results: A total of 1105 out-of-hospital cardiac arrest patients were attended by the emergency medical service. Of these, 489 (44.2%) underwent cardiopulmonary resuscitation, and return of spontaneous circulation was achieved in 142 patients (29%). There was a male predominance overall, and the main age was 72.6 years (standard deviation 17.9). Cardiopulmonary resuscitation before emergency medical service arrival was performed on 62 cases (44%) in the return of spontaneous circulation group, and on 115 cases (33%) in the no return of spontaneous circulation group ( p<0.024). Among the 142 cases of return of spontaneous circulation, 29 (5.9%) survived to hospital discharge. There was a smaller likelihood of return of spontaneous circulation when patients were female (odds ratio 0.61, 0.40–0.93). Patients who had an out-of-hospital cardiac arrest with an initial shockable rhythm (odds ratio 6.33, 3.86–10.39) or an age <60 years (odds ratio 2.91, 1.86–4.57) had a greater likelihood of return of spontaneous circulation. In addition, bystander cardiopulmonary resuscitation (odds ratio 1.56, 1.04–2.33) was associated with an increased chance of return of spontaneous circulation. Conclusion: The incidence of out-of-hospital cardiac arrest and survival rate lies within the known range. A wider database is necessary to achieve a better knowledge of out-of-hospital cardiac arrest and to drive future investments in the healthcare system.
Influence of Accelerometer Calibration Approach on Moderate–Vigorous Physical Activity Estimates for Adults
Authors: MATTHEWS CHARLES E. , KEADLE SARAH KOZEY , BERRIGAN DAVID , STAUDENMAYER JOHN , F. SAINT-MAURICE PEDRO , TROIANO RICHARD P. , FREEDSON PATTY S. 
Published: June 2018

ABSTRACT

Purpose
To compare estimates of moderate-vigorous physical activity (MVPA) duration derived from accelerometers calibrated only to walking and running activities to estimates from calibrations based on a broader range of lifestyle and ambulatory activities.

Methods
In a study of 932 older (50–74 yr) adults we compared MVPA estimates from accelerometer counts based on three ambulatory calibration methods (Freedson 1952 counts per minute; Sasaki 2690 counts per minute; activPAL 3+ METs) to estimates based on calibrations from lifestyle and ambulatory activities combined (Matthews 760 counts per minute; Crouter 3+ METs; Sojourn3x 3+ METs). We also examined data from up to 6 previous-day recalls describing the MVPA in this population.

Results
The MVPA duration values derived from ambulatory calibration methods were significantly lower than methods designed to capture a broader range of both lifestyle and ambulatory activities (P < 0.05). The MVPA (h·d−1) estimates in all participants were: Freedson (median, 0.35; interquartile range, 0.17–0.58); Sasaki (median, 0.91; interquartile range, 0.59–1.32); and activPAL (median, 0.97; interquartile range, 0.71–1.26) compared with Matthews (median, 1.82; interquartile range, 1.37–2.34); Crouter (2.28 [1.72–2.82]); and Sojourn3x (median, 1.85; interquartile range, 1.42–2.34). Recall-based estimates in all participants were comparable (median, 1.61; interquartile range, 0.89–2.57) and indicated participation in a broad range of lifestyle and ambulatory MVPA.

Conclusions
Accelerometer calibration studies that employ only ambulatory activities may produce MVPA duration estimates that are substantially lower than methods calibrated to a broader range of activities. These findings highlight the potential to reduce potentially large differences among device-based measures of MVPA due to variation in calibration study design by including a variety of lifestyle and ambulatory activities.
PHOSPHO1 is essential for normal bone fracture healing
Authors: Morcos M. W. , Al-Jallad H. , Li J. , Farquharson C. , Millán J. L. , Hamdy R. C. , Murshed M. 
Published: June 2018

ObjectivesBone fracture healing is regulated by a series of complex physicochemical and biochemical processes. One of these processes is bone mineralization, which is vital for normal bone development. Phosphatase, orphan 1 (PHOSPHO1), a skeletal tissue-specific phosphatase, has been shown to be involved in the mineralization of the extracellular matrix and to maintain the structural integrity of bone. In this study, we examined how PHOSPHO1 deficiency might affect the healing and quality of fracture callus in mice.MethodsTibial fractures were created and then stabilized in control wild-type (WT) and Phospho1-/-mice (n = 16 for each group; mixed gender, each group carrying equal number of male and female mice) at eight weeks of age. Fractures were allowed to heal for four weeks and then the mice were euthanized and their tibias analyzed using radiographs, micro-CT (μCT), histology, histomorphometry and three-point bending tests.ResultsThe μCT and radiographic analyses revealed a mild reduction of bone volume in Phospho1-/-callus, although it was not statistically significant. An increase in trabecular number and a decrease in trabecular thickness and separation were observed in Phospho1-/-callus in comparison with the WT callus. Histomorphometric analyses showed that there was a marked increase of osteoid volume over bone volume in the Phospho1-/-callus. The three-point bending test showed that Phospho1-/-fractured bone had more of an elastic characteristic than the WT bone.ConclusionOur work suggests that PHOSPHO1 plays an integral role during bone fracture repair and may be a therapeutic target to improve the fracture healing process. Cite this article: M. W. Morcos, H. Al-Jallad, J. Li, C. Farquharson, J. L. Millán, R. C. Hamdy, M. Murshed. PHOSPHO1 is essential for normal bone fracture healing: An Animal Study. Bone Joint Res 2018;7:397–405. DOI: 10.1302/2046-3758.76.BJR-2017-0140.R2.
Participação Social na Elaboração do Orçamento Público Municipal: Uma Análise do Orçamento Participativo de Porto Alegre (RS) e Belo Horizonte (MG)
Authors: Dos Anjos Daniela Araújo , Vieira Michelle Aparecida , Abrantes Luiz Antônio 
Published: June 2018

Este estudo objetivou identificar e ressaltar as características que contribuem para a consolidação e êxito do orçamento participativo (OP)em Porto Alegre (RS) e Belo Horizonte (MG). Para tanto, utilizou-se um levantamento bibliográfico de artigos publicados no período de 1994 a 2015. Apesar dos entraves existentes, as experiências analisadas demonstram um avanço no contexto da participação social ao permitir uma atuação cidadã mais ativa nas decisões governamentais. Percebe-se que mais participação torna-se possível por meio da educação cívica dos cidadãos, que reconhecem sua importância enquanto atores sociais e não deixam as responsabilidades das decisões públicas apenas para os governantes. Portanto, o OP tem ajudado a promover uma mudança na conscientização dos cidadãos, que estão atuando mais ativamente e exercendo de fato a sua cidadania por meio dos processos participativos, cenário que tem contribuído para a consolidação das experiências de OP tanto em Porto Alegre quanto em Belo Horizonte.
The state of fashion studies in France: Past, present, future
Authors: Bass-Krueger Maude , Kurkdjian Sophie 
Published: June 2018

Abstract
This article explores the paradoxical nature of the state of fashion studies in France. Despite France’s long history of fostering innovative theoretical research in fashion studies and its rich cultural fashion heritage, the current state of French fashion studies lags in comparison to its Anglo-American and Northern European neighbours. The institutionalization of fashion studies is just beginning to happen in France. Currently, French fashion studies denotes an ‘umbrella’ term used to cover the range of scholars working in France on the social, cultural, political, economic and theoretical studies of garments and their systems of production, consumption and representations. This article discusses the current state of fashion research in France and attempts to map the landscape in terms of the main researchers, universities, programmes, departments, and public and private initiatives. The authors look at the hurdles and challenges that the discipline faces in France and discuss potential trajectories, areas for improvement and promising new projects.