bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and evaluation of a food frequency questionnaire to assess nutrient intakes of adult women in New Zealand
Authors: Beck Kathryn L. , Houston Zara L. , McNaughton Sarah A. , Kruger Rozanne 
Published: September 2018

AimIn New Zealand, there are few adequate food frequency questionnaires for assessing dietary intake. This study aimed to develop and assess the relative validity of a multi‐nutrient, culturally appropriate, semi‐quantitative food frequency questionnaire for use in young adult New Zealand women (the New Zealand Women's Food Frequency Questionnaire (NZWFFQ)).MethodsWomen (n = 110) aged 16–45 years of Māori, Pacific or European ethnicity completed a NZWFFQ assessing dietary intake over the previous month, and a 4‐day weighed food record. Relative validity was evaluated by comparing nutrient intakes from the NZWFFQ with the food record using Spearman's rank correlation coefficients, cross‐classification, the weighted kappa statistic and Bland–Altman analysis.ResultsNutrient intake was higher from the NZWFFQ compared with the food record for all nutrients (range: 1%–64% difference) except alcohol (−16% difference). Energy‐adjusted correlations ranged from 0.23 to 0.67 (average 0.48). Correct classification into same and adjacent quartiles was over 70% for all nutrients except folate and vitamin D. Gross misclassification into opposite quartiles ranged from 1% (monounsaturated fat, magnesium, calcium) to 10% (iron). The weighted kappa showed poor agreement for vitamin D and folate, fair agreement for most nutrients, and moderate agreement for fibre, vitamin E, magnesium, calcium and phosphorus.ConclusionsThe NZWFFQ overestimated intake of nearly all nutrients. While not suitable for assessing absolute intake, the NZWFFQ is suitable for ranking individuals based on nutrient intake demonstrating reasonable relative validity for this purpose.
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling
Authors: Ma Xingjie , Warnier Marine , Raynard Clotilde , Ferrand Mylène , Kirsh Olivier , Defossez Pierre‐Antoine , Martin Nadine , Bernard David 
Published: September 2018

AbstractCalcium signaling is emerging as a key pathway controlling cellular senescence, a stable cell proliferation arrest playing a fundamental role in pathophysiological conditions, such as embryonic development, wound healing, cancer, and aging. However, how calcium signaling is regulated is still only partially understood. The inositol 1, 4, 5‐trisphosphate receptor type 2 (ITPR2), an endoplasmic reticulum calcium release channel, was recently shown to critically contribute to the implementation of senescence, but how ITPR2 expression is controlled is unclear. To gain insights into the regulation of ITPR2 expression, we performed an siRNA screen targeting 160 transcription factors and epigenetic regulators. Interestingly, we discovered that the retinoid X receptor alpha (RXRA), which belongs to the nuclear receptor family, represses ITPR2 expression and regulates calcium signaling though ITPR2 and the mitochondrial calcium uniporter (MCU). Knockdown of RXRA induces the production of reactive oxygen species (ROS) and DNA damage via the ITPR2‐MCU calcium signaling axis and consequently triggers cellular senescence by activating p53, whereas RXRA overexpression decreases DNA damage accumulation and then delays replicative senescence. Altogether, our work sheds light on a novel mechanism controlling calcium signaling and cellular senescence and provides new insights into the role of nuclear receptors.
Imagining Christian Sex: Reproductive Governance and Modern Marriage in Oaxaca, Mexico
Authors: Ramirez Michelle , Everett Margaret 
Published: September 2018

ABSTRACTA large body of scholarship examines how Pentecostal and evangelical churches alter gender relations in Latin America. Some argue that these churches reform even the most liberation‐resistant social structures—the domestic sphere—by fundamentally reordering the relative participation of women and men in this realm. What has received less attention are the sexual responsibilities assigned to women that are a recommended part of Pentecostal gender reforms. In a longitudinal ethnographic study examining Pentecostal healing in Oaxaca, the authors observed companionate marital training where women are warned not to put their children before their husbands, as women's conjugal relationships are portrayed to be more central to their gender identity than motherhood. We examine the history of companionate marriage in Mexico and discover parallel commitments of various state institutions and religious actors to reform key aspects of gender in Mexico. We employ the theory of reproductive governance to understand how moral regimes directed toward reproductive behaviors and practices are fully entangled with political, economic, and modernizing projects. By examining the history of this particular modernity project, we hope to contribute to ongoing debates about women's participation in evangelical Christianity in Latin America. [gender, sexuality, Pentecostalism, Mexico]
Mastering Submission: Palestinian Poets Measuring Sounds of “Freedom”
Authors: Furani Khaled 
Published: September 2018

ABSTRACTThis article examines how Palestinian poets experience “freedom” when they compose with traditional rhythms in Arabic verse. In analyzing narratives by poets on their introduction to, training in, and mastery of metrical discipline, I argue that these seemingly “technical” practices host an exercise of “freedom” strikingly at odds with dominant liberal modalities, which pit freedom against submission. In contrast with modernizing poets who posit sovereignty of the self as a prerequisite for freedom, poets who vindicate metrical composition measure their sounds in an aliberal space of “freedom,” which then enables them to contest various forms of authority in society. This study illustrates the analytical possibilities that become available to an ethnographic inquiry into “freedom” when surrendering normative liberal paradigms of self‐sovereignty. [freedom, poetry, ethics, liberalism, Palestine]
Reduction in throughfall reduces soil aggregate stability in two subtropical plantations
Authors: Yang Y. J. , Liu S. R. , Wang H. , Chen L. , Lu L. H. , Cai D. X. 
Published: September 2018

SummaryClimate change has altered global precipitation regimes in terms of intensity and frequency of drought stress and, consequently, it is likely to affect soil moisture and soil aggregation. However, we know little about the effects of drought on soil aggregate size, distribution and stability, and how that affects carbon sequestration. A drought manipulation experiment was conducted by throughfall exclusion treatment (TET) of 50% in two planted forests (Pinus massoniana Lamb. and Castanopsis hystrix A.DC.) in subtropical China. The aim was to investigate the effects of a reduction in throughfall on aggregate size, distribution and stability. The results from the 4‐year experiment show that the TET affected soil moisture content significantly (with 14.5 and 20.4% decreases in the P. massoniana and C. hystrix plantations, respectively) compared with the control. Soil temperature at 0–5‐cm soil depth and soil texture were not affected significantly. Soil porosity in the TET plots was greater than that of the control, whereas soil bulk density and free Al oxide content were less. The mass fractions of macroaggregates (> 0.25 mm) and mean weight diameter (MWD) of aggregates, an indicator of aggregate stability, decreased in the TET compared with the control. Variation in aggregate size, distribution and stability can be caused by Fe and Al oxides, soil texture, bulk density and porosity. Our results indicated that TET reduced soil aggregate stability in subtropical plantations because of a decrease in free Al oxide and an increase in porosity. Slaking effects from variation in soil moisture were also possible for the decreased MWD. This study suggests disturbance of forest soils should be minimized in the context of a decline in precipitation.Highlights
Size, distribution and stability of forest soil aggregates were evaluated under throughfall exclusion.
TET reduced free Al oxide content but increased soil porosity, leading to breakdown of macroaggregates.
Soil aggregate stability was reduced by TET.
Fe and Al oxides and soil texture contributed more than SOC to aggregate size and stability.
Enhanced gross primary production and evapotranspiration in juniper‐encroached grasslands
Authors: Wang Jie , Xiao Xiangming , Zhang Yao , Qin Yuanwei , Doughty Russell B. , Wu Xiaocui , Bajgain Rajen , Du Ling 
Published: September 2018

AbstractWoody plant encroachment (WPE) into grasslands has been occurring globally and may be accelerated by climate change in the future. This land cover change is expected to alter the carbon and water cycles, but it remains uncertain how and to what extent the carbon and water cycles may change with WPE into grasslands under current climate. In this study, we examined the difference of vegetation indices (VIs), evapotranspiration (ET), gross primary production (GPP), and solar‐induced chlorophyll fluorescence (SIF) during 2000–2010 between grasslands and juniper‐encroached grasslands. We also quantitatively assessed the changes of GPP and ET for grasslands with different proportions of juniper encroachment (JWPE). Our results suggested that JWPE increased the GPP, ET, greenness‐related VIs, and SIF of grasslands. Mean annual GPP and ET were, respectively, ~55% and ~45% higher when grasslands were completely converted into juniper forests under contemporary climate during 2000–2010. The enhancement of annual GPP and ET for grasslands with JWPE varied over years ranging from about +20% GPP (~+30% for ET) in the wettest year (2007) to about twice as much GPP (~+55% for ET) in the severe drought year (2006) relative to grasslands without encroachment. Additionally, the differences in GPP and ET showed significant seasonal dynamics. During the peak growing season (May–August), GPP and ET for grasslands with JWPE were ~30% and ~40% higher on average. This analysis provided insights into how and to what degree carbon and water cycles were impacted by JWPE, which is vital to understanding how JWPE and ecological succession will affect the regional and global carbon and water budgets in the future.
What drives youth unemployment in Europe? Economic vs non‐economic determinants
Authors: TOMIĆ Iva 
Published: September 2018

AbstractThis article explores the main determinants of youth unemployment in Europe in the period 2002 to 2014 by estimating panel data models for the 28 Member States of the European Union (EU). Heterogeneity is acknowledged by estimating models for subsamples of countries with “high” and “low” youth unemployment rates. The main results suggest that youth unemployment is more pronounced in countries with poor GDP growth, a low share of construction activity and high public debt. Reduced mobility (owing to homeownership), corruption, reception of a high level of remittances and a lack of possibilities for young people to live outside parental homes are also important factors.
The role of the Synechocystis sp. PCC 6803 homolog of the circadian clock output regulator RpaA in day–night transitions
Authors: Köbler Christin , Schultz Siri‐Jasmin , Kopp Dominik , Voigt Karsten , Wilde Annegret 
Published: September 2018

SummaryCyanobacteria exhibit rhythmic gene expression with a period length of 24 hours to adapt to daily environmental changes. In the model organism Synechococcuselongatus PCC 7942, the central oscillator consists of the three proteins KaiA, KaiB and KaiC and utilizes the histidine kinase SasA and its response regulator RpaA as output‐signaling pathway. Synechocystis sp. PCC 6803 contains in addition to the canonical kaiAB1C1 gene cluster two further homologs of the kaiB and kaiC genes. Here, we demonstrate that the SasA‐RpaA system interacts with the KaiAB1C1 core oscillator only. Interaction with KaiC2 and KaiC3 proteins was not detected, suggesting different signal transduction components for the clock homologs. Inactivation of rpaA in Synechocystis sp. PCC 6803 leads to reduced viability of the mutant in light‐dark cycles, especially under mixotrophic growth conditions. Chemoheterotrophic growth of the ∆rpaA strain in the dark was abolished completely. Transcriptomic data revealed that RpaA is mainly involved in the regulation of genes related to CO2‐ acclimation in the light and to carbon metabolism in the dark. Further, our results indicate a link between the circadian clock and phototaxis.
Intergroup Toleration and Its Implications for Culturally Diverse Societies
Authors: Verkuyten Maykel , Yogeeswaran Kumar , Adelman Levi 
Published: September 2018

AbstractIn recent decades, tolerance has been proposed as a necessary response to the global rise in cultural and religious diversity. Tolerance is widely embraced in community, national, and international policies, in relation to many types of differences between people and groups. However, in both public and academic discourse, the notion of tolerance appears to have various meanings, which limits our ability to create, evaluate, and implement effective policies. To discuss various policy implications of toleration, we first consider the concept of toleration and its difference from prejudice. We then discuss existing research on intergroup tolerance, the importance of perspective taking, the asymmetry of tolerance, and the boundaries of toleration. Subsequently, we discuss research that indicates that the discourse of tolerance can function as a dimension of intergroup comparison that leads to acceptance or rejection of cultural and religious minority groups. Furthermore, we consider the depoliticized effects that tolerance discourse might have and the possible negative psychological consequences for groups that are tolerated in society. Gaps in existing knowledge are considered and policy implications are explored throughout.
Qualitative study investigating the perceptions of parents of children who failed vision screening at the age of 4–5 years
Authors: Bruce Alison , Sanders Tom , Sheldon Trevor A 
Published: September 2018

ObjectiveTo explore in depth parents’ experiences and understanding of their children’s eye care in order to better comprehend why there is relatively low uptake of services and variable adherence to treatment.DesignSemistructured interviews, informed by the Health Belief framework, were conducted with parents of children who had failed vision screening at age 4–5 years. Four were parents of children who never attended follow-up, 11 had children who attended but did not adhere to spectacle wear and 5 parents of children who had attended and adhered. Interviews were recorded and transcribed verbatim; thematic analysis based on the constant comparative method was undertaken.ResultsParents’ beliefs led to uncertainty about the benefit of treatment, with parents testing their children to confirm the presence of a vision deficit and seeking advice from other family and community members. The stigma of spectacle wear explained the resistance of some to their child’s treatment with the maintenance of ‘normality’ often more important than clinical advice. The combination of parents’ own health beliefs, stigma and the practicalities of attending appointments together influenced parental decisions. Attendance following vision screening and the decision to adhere to spectacle wear were primarily based on the perceived severity of the visual reduction with the perceived benefit of spectacle wear outweighing any negative consequences.ConclusionsHealthcare professionals require a greater understanding of parents’ decision-making processes in order to provide personalised information. Knowledge of the cues to attendance and adherence provides policy makers a framework with which to review the barriers, develop strategies and redesign children’s eye care pathways.
Systematic review and meta-analysis of pre-hospital diagnostic accuracy studies
Authors: Wilson Caitlin , Harley Clare , Steels Stephanie 
Published: September 2018

IntroductionParamedics are involved in examining, treating and diagnosing patients. The accuracy of these diagnoses is evaluated using diagnostic accuracy studies. We undertook a systematic review of published literature to provide an overview of how accurately paramedics diagnose patients compared with hospital doctors. A bivariate meta-analysis was incorporated to examine the range of diagnostic sensitivity and specificity.MethodsWe searched MEDLINE, CINAHL, Embase, AMED and the Cochrane Database from 1946 to 7 May 2016 for studies where patients had been given a diagnosis by paramedics and hospital doctors. Keywords focused on study type (‘diagnostic accuracy’), outcomes (sensitivity, specificity, likelihood ratio?, predictive value?) and setting (paramedic*, pre-hospital, ambulance, ‘emergency service?’, ‘emergency medical service?’, ‘emergency technician?’).Results2941 references were screened by title and/or abstract. Eleven studies encompassing 384 985 patients were included after full-text review. The types of diagnoses in one of the studies encompassed all possible diagnoses and in the other studies focused on sepsis, stroke and myocardial infarction. Sensitivity estimates ranged from 32% to 100% and specificity estimates from 14% to 100%. Eight of the studies were deemed to have a low risk of bias and were incorporated into a meta-analysis which showed a pooled sensitivity of 0.74 (0.62 to 0.82) and a pooled specificity of 0.94 (0.87 to 0.97).DiscussionCurrent published research suggests that diagnoses made by paramedics have high sensitivity and even higher specificity. However, the paucity and varying quality of studies indicates that further prehospital diagnostic accuracy studies are warranted especially in the field of non-life-threatening conditions.PROSPERO registration numberCRD42016039306.
The validity of Ti-in-zircon thermometry in low temperature eclogites
Authors: Lin Meng , Zhang Guibin , Song Shuguang , Li Huijuan , Zhang Lijuan 
Published: September 2018

Abstract

The Ti-in-zircon thermometer has been widely applied to different high-grade metamorphism rocks owing to its simplicity. Based on the calibration of Ferry & Watson (2007; New thermodynamic models and revised calibrations for the Ti-in-zircon and Zr-in-rutile thermometers.
Contributions to Mineralogy and Petrology
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154
, 429–437), we used the Ti-in-zircon thermometer to estimate the metamorphic temperatures for low-temperature eclogites of North Qilian and Western Tianshan, China, and compiled HP/UHP eclogites from the literature. The Ti-in-zircon temperatures are generally higher than the estimations by other thermometers, especially when metamorphic temperatures are lower than 650°C. Although temperature exerts the dominant control on Ti content in zircon, other factors (e.g. lattice defect, other trace element substitutions in zircon, disequilibrium zircon growth, and precipitation from metamorphic fluids) may have contributed to the overestimated Ti-in-zircon temperatures.
Human fetal hearts with tetralogy of Fallot have altered fluid dynamics and forces
Authors: Wiputra Hadi , Chen Ching Kit , Talbi Elias , Lim Guat Ling , Soomar Sanah Merchant , Biswas Arijit , Mattar Citra Nurfarah Zaini , Bark David , Leo Hwa Liang , Yap Choon Hwai 
Published: September 2018

Studies have suggested the effect of blood flow forces in pathogenesis and progression of some congenital heart malformations. It is therefore of interest to study the fluid mechanic environment of the malformed prenatal heart, such as the tetralogy of Fallot (TOF), especially when little is known about fetal TOF. In this study, we performed patient-specific ultrasound-based flow simulations of three TOF and seven normal human fetal hearts. TOF right ventricles (RVs) had smaller end-diastolic volumes (EDVs) but similar stroke volumes (SVs), whereas TOF left ventricles (LVs) had similar EDVs but slightly increased SVs compared with normal ventricles. Simulations showed that TOF ventricles had elevated systolic intraventricular pressure gradient (IVPG) and required additional energy for ejection but IVPG elevations were considered to be mild relative to arterial pressure. TOF RVs and LVs had similar pressures because of equalization via ventricular septal defect (VSD). Furthermore, relative to normal, TOF RVs had increased diastolic wall shear stresses (WSS) but TOF LVs were not. This was caused by high tricuspid inflow that exceeded RV SV, leading to right-to-left shunting and chaotic flow with enhanced vorticity interaction with the wall to elevate WSS. Two of the three TOF RVs but none of the LVs had increased thickness. As pressure elevations were mild, we hypothesized that pressure and WSS elevation could play a role in the RV thickening, among other causative factors. Finally, the endocardium surrounding the VSD consistently experienced high WSS because of RV-to-LV flow shunt and high flow rate through the over-riding aorta. NEW & NOTEWORTHY Blood flow forces are thought to cause congenital heart malformations and influence disease progression. We performed novel investigations of intracardiac fluid mechanics of tetralogy of Fallot (TOF) human fetal hearts and found essential differences from normal hearts. The TOF right ventricle (RV) and left ventricle had similar and elevated pressure but only the TOF RV had elevated wall shear stress because of elevated tricuspid inflow, and this may contribute to the observed RV thickening. TOF hearts also expended more energy for ejection.
Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways
Authors: Neves Karla Bianca , Nguyen Dinh Cat Aurelie , Alves-Lopes Rheure , Harvey Katie Yates , Costa Rafael Menezes da , Lobato Nubia Souza , Montezano Augusto Cesar , Oliveira Ana Maria de , Touyz Rhian M. , Tostes Rita C. 
Published: September 2018

Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance. However, the role of chemerin on insulin signaling in the vasculature is still unknown. We aimed to determine whether chemerin reduces vascular insulin signaling and whether there is interplay between chemerin/ChemR23, insulin resistance, and vascular complications associated with type 2 diabetes (T2D). Molecular and vascular mechanisms were probed in mesenteric arteries and cultured vascular smooth muscle cells (VSMCs) from C57BL/6J, nondiabetic lean db/m, and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). Chemerin decreased insulin-induced vasodilatation in C57BL/6J mice, an effect prevented by CCX832 (ChemR23 antagonist) treatment. In VSMCs, chemerin, via oxidative stress- and ChemR23-dependent mechanisms, decreased insulin-induced Akt phosphorylation, glucose transporter 4 translocation to the membrane, and glucose uptake. In HMECs, chemerin decreased insulin-activated nitric oxide signaling. AMP-activated protein kinase phosphorylation was reduced by chemerin in both HMECs and VSMCs. CCX832 treatment of db/db mice decreased body weight, insulin, and glucose levels as well as vascular oxidative stress. CCX832 also partially restored vascular insulin responses in db/db and high-fat diet-fed mice. Our novel in vivo findings highlight chemerin/ChemR23 as a promising therapeutic target to limit insulin resistance and vascular complications associated with obesity-related diabetes.NEW & NOTEWORTHY Our novel findings show that the chemerin/chemerin receptor 23 axis plays a critical role in diabetes-associated vascular oxidative stress and altered insulin signaling. Targeting chemerin/chemerin receptor 23 may be an attractive strategy to improve insulin signaling and vascular function in obesity-associated diabetes.