bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-profile pattern reconfigurable patch antenna with dual bands characteristic for 5G NR communication
Authors: Wang Zhonggen , Ma Jianguo , Nie Wenyan , Mu Weidong 
Published: November 2024

Abstract
In this paper, a low-profile antenna with characteristic of reconfigurable of dual bands’ pattern for 5G New Radio (NR) communication is proposed to mitigate the problems of signal fading and multipath propagation. The design incorporates a turnstile-shaped patch, a circular patch with etched rectangular slots and a discontinuous ring patch. The circular patch with etched rectangular slots and discontinuous ring patch are placed in the same plane to obtain dual band characteristic. The discontinuous ring patch works as a near-field resonant parasitic unit to improve the front-to-back ratio values at the resonance points and adjust the beam direction. Eight diodes are loaded to control the connection states of the rectangle slots on the circular patch. By combining an electric dipole formed by diode-controlled slot with a magnetic dipole formed by the turnstile-shaped patch, then a dual-band antenna with diverse patterns is designed. The measured results show that the designed antenna has dual-band characteristics and operates in the bands of 3.39–3.62 GHz and 4.77–5.01 GHz with peak gains of 3.6 dBi and 4.2 dBi, respectively. Furthermore, the measured radiation pattern results show that it is feasible to reconfigure the pattern in both bands simultaneously at 45° intervals.
Transgressive segregation and the inheritance of paraquat resistance in horseweed (Erigeron canadensis)
Authors: Hickmott Hayley , Tardif François J. , Laforest Martin , Rajcan Istvan , Meloche Sydney , Thibodeau Alyssa , Bedal Emma , Page Eric R 
Published: November 2024

Abstract
Transgressive segregation refers to the phenomenon whereby the progeny of a diverse cross exhibit phenotypes that fall outside the range of the parents for a particular trait of interest. Segregants that exceed the parental values in life-history traits contributing to survival and reproduction may represent beneficial new allelic combinations that are fitter than respective parental genotypes. In this research, we use geographically disparate paraquat-resistant biotypes of horseweed (Canada fleabane) [Erigeron canadensis L.; syn.: Conyza canadensis (L.) Cronquist] to explore transgressive segregation in biomass accumulation and the inheritance of the paraquat resistance trait in this highly self-fertilizing species. Results of this research indicate that the paraquat resistance traits in E. canadensis biotypes originating in California, USA, and Ontario, Canada, were not conferred by single major gene mechanisms. Segregating generations from crosses among resistant and susceptible biotypes all displayed transgressive segregation in biomass accumulation in the absence of the original selective agent, paraquat. However, when challenged with a discriminating dose of paraquat, progeny from the crosses of susceptible × resistant and resistant × resistant biotypes displayed contrasting responses with those arising from the cross of two resistant biotypes no longer displaying transgressive segregation. These results support the prediction that transgressive segregation is frequently expressed in self-fertilizing lineages and is positively correlated with the genetic diversity of the parental genotypes. When exposed to a new environment, transgressive segregation was observed regardless of parental identity or history. However, if hybrid progenies were returned to the parental environment with exposure to paraquat, the identity of the fittest genotype (i.e., parent or segregant) depends on the history of directional selection in the parental lineages and the dose to which the hybrid progeny was exposed. It is only in the original selective environment that the impact of allelic fixation on transgressive segregation can be observed.
Influence of Lithology and Biota on Stream Erosivity and Drainage Density in a Semi‐Arid Landscape, Central Chile
Authors: Lodes Emma , Scherler Dirk , Wittmann Hella , Schleicher Anja M. , Stammeier Jessica A. , Loyola Lafuente Martín Andrés , Grigusova Paulina 
Published: November 2024

AbstractDrainage density is a fundamental landscape feature that determines the length scale for hillslope sediment transport and results from the competition of diffusive hillslope and advective stream incision processes, whose efficiencies are known to vary with rock type but are notoriously difficult to quantify. Here, we present a comprehensive analysis of a catchment in semi‐arid Central Chile, where landscapes with different drainage densities, but equal tectonic and climatic conditions, have formed on three neighboring granitoid plutons (a monzogranite and two diorites). We combined topographic analysis of a 1‐m digital elevation model with 10Be‐derived denudation rates to estimate stream erosivity and soil diffusivity in the different landscapes. We find that the higher drainage density in the monzogranite is primarily due to higher stream erosivity, whereas soil diffusivity is similar between rock types. Remote sensing data from Landsat imagery confirm field observations of higher vegetation cover in the diorites, especially with regard to deeper‐rooted shrubs, which may result in increased infiltration. Based on geochemical and compositional analyses, we link vegetation differences to a relatively higher abundance of plant‐essential elements in the diorite bedrock. Additionally, the monzogranite's composition and crystal grain size supports more intense physical weathering and leads to a smaller observed hillslope grain size, which increases its erodibility. We conclude that subtle differences in composition and grain size can have a significant impact on stream erosivity and drainage density. Our results demonstrate the importance of taking lithology into account when interpreting fluvial networks and topographic metrics in slowly eroding landscapes.
Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial
Authors: Duan Xuhua , Li Hao , Kuang Donglin , Chen Pengfei , Zhang Mengfan , Li Tengfei , Jiao Dechao , Li Yanliang , He Xiang , Xing Cheng , Wang Haibo , Liu Yaoxian , Xie Limin , Zhang Shixi , Zhang Qiang , Zhu Peixin , Chang Yongchuang , Xie Jichen , Ren Jianzhuang , Han Xinwei 
Published: November 2024

AbstractThis randomized, prospective, multicenter (12 centers in China) phase III trial (Chinese Clinical Trial Registry #ChiCTR2000041170) compared drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with apatinib and DEB-TACE monotherapy for patients with unresectable hepatocellular carcinoma (uHCC). Progression-free survival (PFS) was the primary endpoint. Overall survival (OS), mRECIST-based objective response rates (ORR) and disease control rates (DCR), and treatment-related adverse events (TRAEs) were secondary endpoints. Totally 243 cases were randomized, with 122 and 121 in the DEB-TACE + apatinib and DEB-TACE groups, respectively. Cases administered DEB-TACE + apatinib displayed markedly improved median PFS (7.1 months [95%CI 6.6–8.3] vs. 5.2 months [95%CI 5.0–5.9]) and OS (23.3 months [95%CI 20.7–29.6] vs. 18.9 months [95%CI 17.9–20.1] compared with those treated with DEB-TACE (both p < 0.001). Additionally, patients administered DEB-TACE + apatinib had elevated ORR (56.6% vs. 38.8%) and DCR (89.3% vs. 80.2%) versus the DEB-TACE group (both p < 0.001). Majority of TRAEs were mild and manageable. Regarding DEB-TACE-related TRAEs, the rates of hepatic artery thinning and spasms were elevated during the second DEB-TACE in cases administered DEB-TACE + apatinib vs. DEB-TACE. The commonest apatinib-related TRAEs in the DEB-TACE + apatinib group included hypertension, hand-foot syndrome, fatigue, and diarrhea. In conclusion, DEB-TACE plus apatinib demonstrates superior PFS versus DEB-TACE monotherapy in uHCC cases, maintaining a favorable safety profile with similar occurrences of AEs.
SPINK13 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting Akt phosphorylation
Authors: Lun Yongzhi , Sun Jie , Wei Ling , Liu Ben , Li Zhixue , Dong Wen , Zhao Wenqi 
Published: November 2024

AbstractThe PI3K/Akt pathway is overexpressed in nearly 50% of hepatocellular carcinomas and inhibits apoptosis by promoting the expression of antiapoptotic genes. Serine protease inhibitors have been shown to induce apoptosis in hepatoma cells by downregulating SPINK13 in the PI3K/Akt pathway. In this study, SPINK13 was expressed in lentiviral vectors. Changes in signaling pathway adapter proteins, apoptosis regulatory proteins, cell cycle regulatory proteins, and the biological behavior of hepatocellular carcinoma were observed in cell and nude mouse xenograft models. The underlying mechanism of endogenous SPINK13-induced apoptosis in hepatocellular carcinoma cells was explored via transcriptomics. As a result, endogenous SPINK13 might inhibit the activity of Furin protease, downregulate the Notch1/Hes1 pathway in a binding manner, activate the direct effector PTEN, inhibit Akt phosphorylation, inactivate the downstream PI3K/Akt pathway, and ultimately lead to mitochondrial apoptosis and cell cycle arrest in hepatoma cells. Therefore, the Notch1/Hes1/PTEN pathway may act upstream of SPINK13 to downregulate the PI3K/Akt signaling pathway. Our study helps elucidate the underlying mechanism of SPINK13 in anti-hepatocellular carcinoma and lays a theoretical foundation for the development of novel therapeutic serine protease inhibitors.
TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis
Authors: Ren Wenlong , Liang Huichun , Sun Jian , Cheng Zhuo , Liu Wenjing , Wu Yingying , Shi Yujie , Zhou Zhongmei , Chen Ceshi 
Published: November 2024

AbstractAngiogenesis is well known to play a critical role in breast cancer. We previously reported that TNFAIP2 activates Rac1 to promote triple-negative breast cancer (TNBC) cell proliferation, migration, and chemoresistance. However, the potential contribution of TNFAIP2 to tumor angiogenesis remains unknown. In this study, we demonstrated that TNFAIP2 promotes TNBC angiogenesis by activating the Rac1-ERK-AP1-HIF1α signaling axis. Under hypoxia, TNFAIP2 activates Rac1 and ERK sequentially. Following that, ERK activates the AP-1 (c-Jun/Fra1) transcription factor. By employing chromatin immunoprecipitation and luciferase reporter assays, we showed that AP-1 directly interacts with the HIF1α gene promoter, thereby enhancing its transcription. The combined application of ERK inhibitors, U0126 or trametinib, with the VEGFR inhibitor Apatinib, additively suppresses angiogenesis and tumor growth of HCC1806 in nude mice. These findings provide new therapeutic strategies for TNBC.
Proton-exchange induced reactivity in layered oxides for lithium-ion batteries
Authors: Xu Panpan , Guo Xingyu , Jiao Binglei , Chen Jinxing , Zhang Minghao , Liu Haodong , Yu Xiaolu , Appleberry Maura , Yang Zhenzhen , Gao Hongpeng , Yang Fan , Weng Xuefei , Shen Yanbin , Gu Jing , Meng Ying Shirley , Brooks Christopher , Ong Shyue Ping , Chen Zheng 
Published: November 2024

AbstractLiNixCoyMn1-x-yO2 (0 < x, y < 1, NCM) is the dominant positive material for the state-of-the-art lithium-ion batteries. However, the sensitivity of NCM materials to moisture makes their manufacturing, storage, transportation, electrode processing and recycling complicated. Although it is recognized that protons play a critical role in their structure stability and performance, proton exchange with Li+ in NCM materials has not been well understood. Here, we employ advanced characterizations and computational studies to elucidate how protons intercalate into the layered structure of NCM, leading to the leaching of Li+ and the formation of protonated NCM. It is found that protonation facilitates cation rearrangement and formation of impurity phases in NCM, significantly deteriorating structural stability. The adverse effects induced by protons become increasingly pronounced with a higher Ni content in NCM. Through a comprehensive investigation into the thermodynamics and kinetics of protonation, we discover that Li deficiencies in NCM materials can be resolved via solution process in the presence of Li+ ions and controlled proton concentration. The underlying mechanism of relithiation is further explored through materials characterizations and kinetics modeling. This work provides crucial insights into controlling structural and compositional defects of Li-ion battery positive material in complicated processing environment.
Dopamine builds and reveals reward-associated latent behavioral attractors
Authors: Naudé Jérémie , Sarazin Matthieu X. B. , Mondoloni Sarah , Hannesse Bernadette , Vicq Eléonore , Amegandjin Fabrice , Mourot Alexandre , Faure Philippe , Delord Bruno 
Published: November 2024

AbstractPhasic variations in dopamine levels are interpreted as a teaching signal reinforcing rewarded behaviors. However, behavior also depends on the motivational, neuromodulatory effect of phasic dopamine. In this study, we reveal a neurodynamical principle that unifies these roles in a recurrent network-based decision architecture embodied through an action-perception loop with the task space, the MAGNet model. Dopamine optogenetic conditioning in mice was accounted for by an embodied network model in which attractors encode internal goals. Dopamine-dependent synaptic plasticity created “latent” attractors, to which dynamics converged, but only locally. Attractor basins were widened by dopamine-modulated synaptic excitability, rendering goals accessible globally, i.e. from distal positions. We validated these predictions optogenetically in mice: dopamine neuromodulation suddenly and specifically attracted animals toward rewarded locations, without off-target motor effects. We thus propose that motivational dopamine reveals dopamine-built attractors representing potential goals in a behavioral landscape.
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis
Authors: Wang XinYue , Jowsey William J. , Cheung Chen-Yi , Smart Caitlan J. , Klaus Hannah R. , Seeto Noon EJ , Waller Natalie JE , Chrisp Michael T. , Peterson Amanda L. , Ofori-Anyinam Boatema , Strong Emily , Nijagal Brunda , West Nicholas P. , Yang Jason H. , Fineran Peter C. , Cook Gregory M. , Jackson Simon A. , McNeil Matthew B. 
Published: November 2024

AbstractDrug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase. We hypothesise that perturbed KatG activity would generate collateral vulnerabilities in isoniazid-resistant katG mutants, providing potential pathway targets to combat isoniazid resistance. Whole genome CRISPRi screens, transcriptomics, and metabolomics were used to generate a genome-wide map of cellular vulnerabilities in an isoniazid-resistant katG mutant strain of M. tuberculosis. Here, we show that metabolic and transcriptional remodelling compensates for the loss of KatG but in doing so generates vulnerabilities in respiration, ribosome biogenesis, and nucleotide and amino acid metabolism. Importantly, these vulnerabilities are more sensitive to inhibition in an isoniazid-resistant katG mutant and translated to clinical isolates. This work highlights how changes in the physiology of drug-resistant strains generates druggable vulnerabilities that can be exploited to improve clinical outcomes.
Mapping the ionosphere with millions of phones
Authors: Smith Jamie , Kast Anton , Geraschenko Anton , Morton Y. Jade , Brenner Michael P. , van Diggelen Frank , Williams Brian P. 
Published: November 2024

AbstractThe ionosphere is a layer of weakly ionized plasma bathed in Earth’s geomagnetic field extending about 50–1,500 kilometres above Earth1. The ionospheric total electron content varies in response to Earth’s space environment, interfering with Global Satellite Navigation System (GNSS) signals, resulting in one of the largest sources of error for position, navigation and timing services2. Networks of high-quality ground-based GNSS stations provide maps of ionospheric total electron content to correct these errors, but large spatiotemporal gaps in data from these stations mean that these maps may contain errors3. Here we demonstrate that a distributed network of noisy sensors—in the form of millions of Android phones—can fill in many of these gaps and double the measurement coverage, providing an accurate picture of the ionosphere in areas of the world underserved by conventional infrastructure. Using smartphone measurements, we resolve features such as plasma bubbles over India and South America, solar-storm-enhanced density over North America and a mid-latitude ionospheric trough over Europe. We also show that the resulting ionosphere maps can improve location accuracy, which is our primary aim. This work demonstrates the potential of using a large distributed network of smartphones as a powerful scientific instrument for monitoring Earth.
Combined influence of quantum iterative reconstruction level and kernel sharpness on image quality in photon counting CT angiography of the upper leg
Authors: Krompaß Kristina , Goldbrunner Florian Andreas , Hartung Viktor , Ergün Süleyman , Peter Dominik , Hendel Robin , Huflage Henner , Patzer Theresa Sophie , Hennes Jan-Lucca , Bley Thorsten Alexander , Grunz Jan-Peter , Gruschwitz Philipp 
Published: November 2024

AbstractAim was to evaluate the influence of different quantum iterative reconstruction (QIR) levels on the image quality of femoral photon-counting CT angiographies (PCD-CTA).Ultra-high resolution PCD-CTA were obtained from both extremities of five extracorporeally-perfused cadavers using constant tube voltage and maximum radiation dose (71.2 ± 11.0 mGy). Images were reconstructed with three kernels (Bv48, Bv60, Bv76) and the four available levels of QIR. Signal attenuation in the arterial lumen, muscle, and fat were measured. Contrast-to-noise ratios (CNR) and blurring scores were calculated for objective assessment. Six radiologists evaluated the subjective image quality using a pairwise comparison tool.Higher QIR level resulted in a decisive image noise reduction, especially with sharper convolution kernels (Bv60: Q1 11.5 ± 6.3 HU vs. Q4 8.4 ± 2.6 HU; p < 0.001). Largest improvement of CNR was recorded with ultra-sharp reconstructions (Bv76: Q1 20.2 ± 4.4 vs. Q4 28.0 ± 3.5; p < 0.001). Blurring decreased with higher QIR levels for soft Bv48, remained constant for medium Bv60, and increased for sharp Bv76 reconstructions. Subjective QIR level preference varied kernel depending, preferred combinations were: Bv48/Q4, Bv60/Q2, Bv76/Q3. Interrater agreement was excellent.Sharp kernels benefited most from noise reduction of higher QIR levels in lower extremity PCD-CTA. In sum, QIR level 3 provided the best objective and subjective image quality results.
The transcription factor Dof3.6/OBP3 regulates iron homeostasis in Arabidopsis
Authors: Xu Peipei , Yang Yilin , Zhao Zhongtian , Hu Jinbo , Xie Junyan , Wang Lihua , Zheng Huiqiong , Cai Weiming 
Published: November 2024

AbstractIron is an essential element for plants. Iron uptake by plants is highly regulated, but the underlying mechanism is poorly understood. Using a truncated fragment of the iron deficiency-responsive bHLH100 gene promoter, we screened the Arabidopsis transcription factor yeast one-hybrid (Y1H) library and identified the DOF family protein, OBP3, as a crucial component of the iron deficiency-signaling pathway. OBP3 is a transcriptional repressor with a C-terminal activation domain. Its expression is induced by iron deficiency. The transgenic lines that overexpress OBP3 exhibited iron overload and premature leaf necrosis, while the obp3 mutant was less tolerant of iron deficiency. It was discovered that OBP3 directly targets the Ib subgroup of bHLH gene promoters. OBP3 interacts with the bHLH transcription factor ILR3 (IAA-LEUCINE RESISTANT3), and their interaction enhances the DNA-binding ability and transcriptional promoting activity of OBP3, resulting in the positive regulation of iron deficiency-response genes. In addition, the E3 Ligase BRUTUS facilitates 26S proteasome-mediated degradation of OBP3 protein to prevent excessive iron uptake in plants. In conclusion, our research emphasizes the vital role of OBP3 in regulating plant iron homeostasis.
Performance comparison of the Shack-Hartmann and pyramid wavefront sensors with a laser guide star for 40 m telescopes
Authors: Oyarzún F. , Heritier C. , Chambouleyron V. , Fusco T. , Rouquette P. , Neichel B. 
Published: November 2024

Context. Upcoming giant segmented mirror telescopes will use laser guide stars (LGS) for their adaptive optics (AO) systems. Two options of wavefront sensors (WFSs) are the Shack-Hartmann wavefront sensor (SHWFS) and the pyramid wavefront sensor (PWFS).
Aims. In this paper, we compare the noise performance of the PWFS and the SHWFS. We aim to identify which of the two is best to use in the context of a single or tomographic configuration.
Methods. To compute the noise performance, we extended a noise model developed for the PWFS to be used with the SHWFS. To do this, we expressed the centroiding algorithm of the SHWFS as a matrix-vector multiplication, which allowed us to use the statistics of noise to compute its propagation through the AO loop. We validated the noise model with end-to-end simulations for telescopes of 8 and 16 m in diameter.
Results. For an AO system with only one WFS, we found that given the same number of subapertures, the PWFS outperforms the SHWFS. For a 40 m telescope, the limiting magnitude of the PWFS is around one magnitude higher than the SHWFS. When using multiple WFS and a generalized least-squares estimator to combine the signal, our model predicts that in a tomographic system, the SHWFS performs better than the PWFS (with a limiting magnitude that is higher by a 0.3 magnitude. When using sub-electron RON detectors for the PWFS, the performance quality is almost identical for the two WFSs.
Conclusions. We find that when using a single WFS with LGS, PWFS is a better alternative than the SH. For a tomographic system, both sensors would give roughly the same performance.