bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, Feasibility, and Radiographic Outcomes of the Anterior Meniscal Takedown Technique to Approach Chondral Defects on the Tibia and Posterior Femoral Condyle: A Matched Control Study
Authors: Merkely Gergo , Minas Tom , Ogura Takahiro , Ackermann Jakob , Barbieri Mestriner Alexandre , Gomoll Andreas H. 
Published: November 2018

Objective Takedown of the anterior meniscus to facilitate exposure of the cartilage defects located on the tibial plateau and/or posterior femoral condyle with subsequent reattachment is being performed clinically; however, clinical evidence is lacking to support the safety of this technique. The aim of this study was therefore to investigate whether meniscal extrusion develops after patients undergo meniscus takedown and transosseous refixation during autologous chondrocyte implantation (ACI). Design We analyzed data from 124 patients with a mean follow-up of 6.8 ± 2.5 years. Sixty-two patients who underwent (ACI) with anterior meniscus takedown and refixation by the senior surgeon (TM), were compared with a matched control group of patients who underwent ACI without meniscus takedown. Meniscal extrusion was investigated by measuring the absolute value and the relative percentage of extrusion (RPE) on 1.5-T magnetic resonance images (MRI) at final follow-up. The number of menisci with radial displacement greater or lesser than 3 mm was determined. In cases where a preoperative MRI was available, both pre- and postoperative meniscal extrusion was evaluated ( n = 30) in those patients undergoing meniscal takedown. Results There was no significant difference in either absolute meniscus extrusion, RPE, or extrusion rate in patients with and without meniscus takedown. Among patients with meniscal takedown and both pre- and postoperative MRI scans, absolute meniscus extrusion, RPE, and extrusion rate showed no significant differences. Conclusion Meniscal takedown and subsequent transosseous refixation is a safe and effective technique for exposure of the tibial plateau and posterior femoral condyle.
The Rise of Patanjali
Authors: Prasad Neena 
Published: November 2018

This case is designed to highlight the marketing strategies adopted by a new entrant in the fast-moving consumer goods (FMCG) sector. The importance of brand architecture in building brand relevance in this competitive environment and enhancing customer loyalty has been put forth as illustrated by the experts. The synchronization of branding strategies and marketing communications in terms of establishing a customer connect purely on the basis of nationalism, price, and natural preparations have been highlighted from the perspective of Patanjali’s growth strategy. The brand has been envied by all the big players of the sector for proving itself as the major disruptor being portrayed in terms of its voluminous sales and ever-rising revenues. This case on Patanjali offers an insight into the strategies followed by a new company to position the brand at the right time and acquire a substantial market share. It also highlights the facts that exceptional competitiveness in distribution strategies may not be the only determinant for effective management of distribution strategies, and the road ahead needs to be rightly sorted out. This case also tries to unlock the path that determines the success the brand Patanjali has achieved which otherwise took decades for Nestle, Proctor & Gamble, ITC, or Unilever to achieve.
Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
Authors: Dreyling Martin , Klapper Wolfram , Rule Simon 
Published: November 2018

Abstract
Blastoid mantle cell lymphoma is characterized by highly aggressive features and a dismal clinical course. These blastoid and pleomorphic variants are defined by cytomorphological features, but the criteria are somewhat subjective. The diagnosis may be supported by a high cell proliferation based on the Ki-67 labeling index. Recent analyses have shown that the Ki-67 index overrules the prognostic information derived from the cytology subtypes. Nevertheless, genetic analysis suggests that blastoid and pleomorphic variants are distinct from classical mantle cell lymphoma. In clinical cohorts, the frequency of these subsets varies widely but probably represents ∼10% of all cases. Chemotherapy regimens commonly used in mantle cell lymphoma, such as bendamustine, rarely achieve prolonged remissions when given at the dosage developed for classical variants of the disease. Thus, high-dose cytarabine–containing regimens with high-dose consolidation may be generally recommended based on the more aggressive clinical course in these patients. However, even with these intensified regimens, the long-term outcome seems to be impaired. Thus, especially in this patient subset, allogeneic transplantation may be discussed at an early time point in disease management. Accordingly, targeted approaches are warranted in these patients, but clinical data are scarce. Ibrutinib treatment results in high rates of responses, but the median duration of remission is <6 months. Similarly, lenalidomide and temsirolimus result in only short-term remissions. Novel approaches, such as chimeric antigenic receptor T cells, may have the potential to finally improve the dismal long-term outcome of these patients.
Immunodeficiency-associated lymphoproliferative disorders: time for reappraisal?
Authors: Natkunam Yasodha , Gratzinger Dita , Chadburn Amy , Goodlad John R. , Chan John K. C. , Said Jonathan , Jaffe Elaine S. , de Jong Daphne 
Published: November 2018

AbstractImmunodeficiency-associated lymphoproliferative disorders (IA-LPDs) are pathologically and clinically heterogeneous. In many instances, similar features are shared by a spectrum of IA-LPDs in clinically diverse settings. However, the World Health Organization (WHO) classifies IA-LPDs by their immunodeficiency setting largely according to the paradigm of posttransplant lymphoproliferative disorders but with inconsistent terminology and disease definitions. The field currently lacks standardization and would greatly benefit from thinking across immunodeficiency categories by adopting a common working vocabulary to better understand these disorders and guide clinical management. We propose a 3-part unifying nomenclature that includes the name of the lesion, associated virus, and the specific immunodeficiency setting for all IA-LPDs. B-cell lymphoproliferative disorders (LPDs) are usually Epstein-Barr virus (EBV)+ and show a spectrum of lesions, including hyperplasias, polymorphic LPDs, aggressive lymphomas, and, rarely, indolent lymphomas. Human herpes virus 8–associated LPDs also include polyclonal and monoclonal proliferations. EBV− B-cell LPDs and T- and NK-cell LPDs are rare and less well characterized. Recognition of any immunodeficiency is important because it impacts the choice of treatment options. There is an urgent need for reappraisal of IA-LPDs because a common framework will facilitate meaningful biological insights and pave the way for future work in the field.
Circulating Adiponectin Levels Are Paradoxically Associated With Mortality Rate: A Systematic Review and Meta-Analysis
Authors: Scarale Maria Giovanna , Fontana Andrea , Trischitta Vincenzo , Copetti Massimiliano , Menzaghi Claudia 
Published: November 2018

Abstract

Context
Some studies have surprisingly indicated that serum adiponectin level is positively related to mortality rate, thus casting doubts on its role as a therapeutic target for cardiovascular disease.

Objective
To summarize evidence about direction, strength, and modulators of this controversial association.

Methods
MEDLINE, Web of Science, CINHAL, Cochrane Library, and Scopus databases were searched from their inception dates through June 2018 for English-language prospective studies reporting the association between adiponectin and all-cause or cardiovascular mortality. Two investigators independently extracted data and assessed study quality using standard criteria following the Preferred Reporting Items for Systematic Reviews and Meta-analyses and The Newcastle-Ottawa Scale. Pooled hazard ratios (HRs) and 95% CIs were derived using fixed- or random-effects models when appropriate, and results were expressed to a 1-SD increment of adiponectin.

Results
We identified 55 studies (n = 61,676 subjects) with all-cause mortality data and 28 (n = 43,979 subjects) studies with cardiovascular mortality data. Pooled HRs were 1.24 (1.17-1.31) and 1.28 (1.19-1.37) for all-cause and cardiovascular mortality, respectively. Similar results were obtained for high-molecular-weight adiponectin. When meta-analyses were restricted to studies reporting data on natriuretic peptides, reductions of 43% and 28% on a log scale of these respective associations were observed after adjusting for natriuretic peptides.

Conclusions
Our results point strongly to a paradoxical association between high adiponectin levels and increased mortality rate, which is partly modulated by natriuretic peptides.
Severe Familial Hypertriglyceridemia: Successful Treatment With Insulin and a Modified Meal Plan
Authors: Ayyavoo Ahila , Raghupathy Palany , Agarwal Meenal , Hofman Paul 
Published: November 2018

AbstractContextMutations in genes encoding the lipoprotein lipase enzyme, its cofactor, or transport proteins can cause severe familial hypertriglyceridemia, resulting in serious complications, such as severe pancreatitis, hepatosplenomegaly, lipid encephalopathy, and failure to thrive. Current treatment includes a low-saturated-fat formula enriched with high medium-chain triglyceride (TGs), oral fibrates, omega-3 fatty acids, or plasmapheresis.Case DescriptionA 71-day-old infant with very severe hypertriglyceridemia and recurrent pancreatitis associated with a likely pathogenic variant in the LPL gene was treated successfully with insulin infusion and a locally prepared low-fat formula feed after stopping breast milk. Subcutaneous insulin was administered daily from 9 to 30 months of age. His serum TG level was markedly lower, although higher than normal. No episodes of hypoglycemia were noted. Fenofibrate and omega-3 fatty acids were ineffective in this infant. At the last follow-up visit, he was 36 months old and growing normally. He was consuming a special meal plan and receiving insulin injections during high-fat meals. Two other young infants with severe hypertriglyceridemia were growing normally after a short course of insulin infusion and the same modified reduced long chain fat diet.ConclusionsInsulin is an unusual and affordable therapeutic option for some patients with severe hypertriglyceridemia and can be helpful in the prevention of acute and chronic complications. Locally available cereals and millets with high crude fiber and a low glycemic index, along with medium chain TGs, was used to prepare an economical special formula at home to maintain TG concentrations in the acceptable limits.
Caffeine Augments the Prothrombotic but Not the Fibrinolytic Response to Exercise
Authors: NAGELKIRK PAUL R. , SACKETT JAMES R. , AIELLO JOSEPH J. , FITZGERALD LIAM F. , SAUNDERS MICHAEL J. , HARGENS TRENT A. , WOMACK CHRISTOPHER J. 
Published: November 2018

ABSTRACT
Caffeine, a popular ergogenic supplement, induces neural and vascular changes that may influence coagulation and/or fibrinolysis at rest and during exercise.

Purpose
The purpose of this study was to assess the effect of a single dose of caffeine on measures of coagulation and fibrinolysis before and after a single bout of high-intensity exercise.

Methods
Forty-eight men (age, 23 ± 3 yr; body mass index, 24 ± 3 kg·m−2) completed two trials, with 6 mg·kg−1 of caffeine (CAFF) or placebo (PLAC), in random order, followed by a maximal cycle ergometer test. Plasma concentrations of fibrinogen, factor VIII antigen, active tissue plasminogen activator (tPA:c), tissue plasminogen activator antigen (tPA:g), and active plasminogen activator inhibitor-1 (PAI-1:c) were assessed at baseline and immediately after exercise.

Results
Exercise led to significant changes in tPA:c (Δ 8.5 ± 4.36 IU·mL−1 for CAFF, 6.6 ± 3.7 for PLAC), tPA:g (Δ 2.4 ± 3.2 ng·mL−1 for CAFF, 1.9 ± 3.1 for PLAC), fibrinogen (Δ 30.6 ± 61.4 mg·dL−1 for CAFF, 28.1 ± 66.4 for PLAC), and PAI-1:c (Δ −3.4 ± 7.9 IU·mL−1 for CAFF, −4.0 ± 12.0 for PLAC) (all P < 0.05), but no effect of condition or time–condition interactions were observed. Main effects of time, condition, and a significant time–condition interaction were observed for factor VIII, which increased from 1.0 ± 0.4 IU·mL−1 to 3.3 ± 1.3 IU·mL−1 with CAFF and 1.0 ± 0.4 IU·mL−1 to 2.4 ± 0.9 IU·mL−1 with PLAC.

Conclusions
Coagulation potential during exercise is augmented after caffeine intake, without a similar increase in fibrinolysis. These results suggest caffeine intake may increase risk of a thrombotic event during exercise.
Exercise Mode Specificity for Preserving Spine and Hip Bone Mineral Density in Prostate Cancer Patients
Authors: NEWTON ROBERT U. , GALVÃO DANIEL A. , SPRY NIGEL , JOSEPH DAVID , CHAMBERS SUZANNE K. , GARDINER ROBERT A. , WALL BRAD A. , BOLAM KATE A. , TAAFFE DENNIS R. 
Published: November 2018

ABSTRACT

Purpose
Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an array of adverse effects, including reduced bone mineral density (BMD) predisposing patients to increased fracture risk. Our purpose was to examine the effects of targeted exercise modes on BMD in men with PCa undergoing ADT.

Methods
Between 2009 and 2012, 154 PCa patients 43–90 yr old on ADT were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training [ImpRes], n = 57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training, n = 50) supervised for 6 months followed by a 6-month home-based program, or delayed aerobic exercise (DelAer, n = 47) received exercise information for 6 months followed by 6 months of supervised aerobic exercise (stationary cycling). End points were lumbar spine, hip and whole-body BMD measured by dual-energy x-ray absorptiometry with secondary end points of lean and fat mass, appendicular skeletal muscle mass, and neuromuscular strength. ANOVA was used to compare the exercise groups with DelAer at 6 and 12 months.

Results
There was a between-group difference in BMD for ImpRes and DelAer at the spine (6 months, P = 0.039; 12 months, P = 0.035) and femoral neck (6 months, P = 0.050), with decline attenuated in ImpRes (~−1.0% vs ~−2.0%). Compared with DelAer, ImpRes increased appendicular skeletal muscle at 6 months (0.3 kg, P = 0.045) and improved muscle strength at 6 and 12 months (P ≤ 0.012) by 9%–34%. A limitation was inclusion of well-functioning patients.

Conclusion
Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCa patients undergoing ADT.
A Decomposition Method for Finding Optimal Container Stowage Plans
Authors: Roberti R. , Pacino D. 
Published: November 2018

In transportation of goods in large container ships, shipping industries need to minimize the time spent at ports to load/unload containers. An optimal stowage of containers on board minimizes unnecessary unloading/reloading movements, while satisfying many operational constraints. We address the basic container stowage planning problem (CSPP). Different heuristics and formulations have been proposed for the CSPP, but finding an optimal stowage plan remains an open problem even for small-sized instances. We introduce a novel formulation that decomposes CSPPs into two sets of decision variables: the first defining how single container stacks evolve over time and the second modeling port-dependent constraints. Its linear relaxation is solved through stabilized column generation and with different heuristic and exact pricing algorithms. The lower bound achieved is then used to find an optimal stowage plan by solving a mixed-integer programming model. The proposed solution method outperforms the methods from the literature and can solve to optimality instances with up to 10 ports and 5,000 containers in a few minutes of computing time. The online appendix is available at https://doi.org/10.1287/trsc.2017.0795 .
The F word: Midwifery students' understanding of feminism
Authors: Davison Clare , Geraghty Sadie , Dobbs Kirsten 
Published: November 2018

Background Not all midwives embrace the word feminism however, it could be argued that providing midwifery care is an expression of feminism's core values. Aims To describe and explain the views and knowledge of midwifery students on feminism and midwifery. Methods A qualitative descriptive approach, employing an anonymous online questionnaire was implemented and analysed using thematic and content analysis. Findings Eight themes were identified in this study that revealed midwifery student's views and knowledge on feminism and the impact it may have on midwifery clinical practice. Conclusions This study suggests midwifery students should receive adequate education regarding feminism. The advantages of midwifery students understanding feminism within the midwifery professional are undeniable and it is important that feminism is integrated into midwifery programmes.
Anterior cruciate ligament reconstruction without the use of a tourniquet
Authors: Yaghmour KM , Al-Khateeb H 
Published: November 2018

Introduction Anterior cruciate ligament tears are a common ligamentous knee injury and are usually managed with arthroscopic reconstruction surgery using a tourniquet. The employment of a tourniquet in the management of an anterior cruciate ligament tear has been a debatable topic for some time. Here, we discuss our technique in the reconstruction of anterior cruciate ligament tears without the use of a tourniquet. Materials and methods We performed 26 anterior cruciate ligament reconstruction surgeries using hamstring grafts without the use of a tourniquet. The outcomes measured were pain using the visual analogue scale, knee swelling, range of movement and bleeding. Results Using this technique, we have noted considerable reduction in knee swelling and pain. In addition, there was considerable improvement in the range of movement postoperatively, and there were no bleeding complications noted. Conclusions We consider ACL reconstruction without a tourniquet to be an excellent alternative to conventional reconstruction with the use of tourniquet.
Primary School Teachers’ Awareness of Chronic Diseases of Children
Authors: Plisková Barbora , Snopek Petr 
Published: November 2018

Abstract
Introduction: More and more children and adolescents suffering from chronic diseases are included in common school education. Unfortunately, teachers do not feel confident enough about how to cope, fulfil and satisfy the needs of these children in the educational, social and emotional spheres. The aim ofp this part of research was to discover how teachers work with chronically ill children of younger school-age. There were three aims. The first aim was to investigate if teachers have basic awareness and knowledge about selected chronic diseases in children of younger school-age. The second aim was to discover what experience and attitudes towards chronically ill children of younger school-age teachers have. The third aim was to discover, how the quality of school care of chronically ill children of younger school-age can be improved. Methods: We used qualitative research methodology. Data were processed and gathered from semi-structured interviews. Interviews were conducted with 12 teachers. Results: Our findings revealed that teachers should be acquainted with the disease itself and its consequences in all aspects. In some cases, teachers must be acquainted also with the practical aspects of a chronic disease, e.g. first aid and application of drugs and aids in order to assist children if necessary. Discussion: The study offers unique insights into primary teachers’ views and experiences with chronically ill children, how teachers work with chronically ill pupils of younger school-age and how the quality of school care of chronically ill children of younger school-age can be improved. Limitations: The research is still being conducted and therefore, it is not possible to provide more detailed results and conclusions. However, our main aim was to draw attention to the very problem from the point of view of teachers themselves and to highlight their vivid experiences. Conclusions: It is necessary to create interconnected networks of experts and families who will cooperate and communicate and who will participate in satisfying needs of a child together. These networks will ensure that children will be integrated into common school life in spite of their disease without serious consequences affecting their development and education.
Study of different extraction methods on finger print and fatty acid of raw beef fat using fourier transform infrared and gas chromatography-mass spectrometry
Authors: Aminullah  , Mardiah  , Sutsuga Hanna , Kemala Tetty 
Published: November 2018

Abstract
Beef fat was an extracted fat that a byproduct of beef processing industry. In this research, the objective was to study the effect of extraction methods on finger prints and fatty acid profiles of beef fat and to obtain the chosen extraction method. This study consisted of two steps namely extracting beef fat using Soxhlet, Folch, Bligh and Dyer, and Hara and Radin methods as well as characterizing the finger print using FTIR and fatty acid profiling using GCMS. The total lipid by Soxhlet, Folch, Bligh & Dyer, and Hara & Radin methods were 89.67%, 81.73%, 55.16%, and 84.40%, respectively. Statistical analysis showed that the saturated fatty acid in Folch was not significantly different with that in Soxhlet and Hara and Radin at a 5% level. Polyunsaturated fatty acids such as linoleic and linolenic acids are present in all methods, where linoleic acid was the highest in Folch and linolenic acid was the lowest in Bligh and Dyer. The PCA analysis showed that only Folch that can be differentiated and has minimal residual error values. The results of the finger print analysis showed the extraction methods which were used are not different. These data showed that Folch was the chosen method for extracting beef fat.
DMFDMA catalyzed synthesis of 2-((Dimethylamino)methylene)-3,4-dihydro-9-arylacridin-1(2H)-ones and their derivatives: in-vitro antifungal, antibacterial and antioxidant evaluations
Authors: Jyothish Kumar L. , Sarveswari S. , Vijayakumar V. 
Published: November 2018

Abstract
A series of 3,4-dihydro-9-arylacridin-1(2H)-ones was synthesized and enaminone function was introduced at the C-2 position using DMFDMA catalyst which in turn successfully converted into pyrazole, isoxazol, 1-phenyl-1H-pyrazole by treating it with reagents such as hydrazine, hydroxylamine and phenylhydrazine. These newly synthesized compounds were evaluated for their antibacterial activity against a series of Gram-Positive bacteria including Staphylococcus aureus, Bacillus cereus, Staphylococcus aureus MLS16 and Gram-Negative bacteria including Klebsiella planticol, Escherichia coli and Pseudomonas aeruginosa and also against fungal strains including Candida albicans, Candida parapsilosis, Candida glabrata, Candida aaseri, Aspergillus niger and Issatchenkia hanoiensis. The compounds 3a and 6a exhibited considerable antifungal activity (MIC value 0.007 and 0.006 μM) against Candida albicans and Aspergillus niger respectively. The compound 4a showed excellent antibacterial activity towards Escherichia Coli (MIC = 0.003 μM) and the compound 5a found to show prominent DPPH radical scavenging activity with EC50 value 16.85±1.5μg mL−1.