bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ambiguities of Belief and Belonging: Catholicism and the Church of the East in the Sixteenth Century
Authors: Parker Lucy 
Published: October 2018

Abstract
This article considers the emergence of the Chaldaean (East Syrian Catholic) Church in the 1550s, a topic of considerable relevance for scholars of eastern Christianity and of Counter-Reformation Catholicism alike. The Chaldaeans seem to present a paradox, in that they broke away from their existing Church and turned towards the papacy for support, yet continued to espouse their traditional beliefs and venerate their traditional saints, deemed heretical by Catholics. This paradox has often been attributed to the Chaldaeans’ ignorance of Catholicism, but this argument risks patronising the Chaldaeans and denying their agency. This article seeks to reconceptualise this problem, arguing that the apparent paradox largely disappears when viewed from an eastern Christian rather than a western Catholic perspective. First, an awareness of the highly tense political situation in Mesopotamia leads us to view some of the apparently contradictory Chaldaean writings as polemical and performative, rather than ignorant and confused. Secondly, it is necessary to appreciate the Chaldaeans’ own sense of religious belief and belonging, rather than trying to impose strict and exclusionary confessional boundaries upon them as if these were universal and unproblematic categories of analysis. Some of their leaders seem to have had an open-minded, perhaps even ecumenical, approach to other Christian churches. They adopted and adapted Catholicism selectively in view of their background and their particular priorities. As individual religious agents they had a greater range of possibilities than has usually been acknowledged. The article thus, from a new perspective, contributes to the scholarly ‘de-centring’ of Tridentine Catholicism.
Why are there gender inequalities in visual impairment?
Authors: Rius Ulldemolins Anna , Benach Joan , Guisasola Laura , Artazcoz Lucía 
Published: October 2018

Abstract

Background
In high-income countries, the prevalence of blindness and visual impairment is higher among women, regardless of age although the mechanisms that produce these gender inequalities are not well understood. The objectives of this study were to analyse gender inequalities in the prevalence of blindness and visual impairment, age of onset, diagnosed and undiagnosed status and related eye diseases among visually impaired individuals.

Methods
Data were obtained from the 2008 Spanish Survey on ‘Disability, Personal Autonomy and Dependency Situations’ (n = 213 626) participants 360 blind (160 men and 200 women), and 5560 with some visual impairment (2025 men and 3535 women). The prevalence of blindness and visual impairment, age of onset of visual impairment and diagnosed and undiagnosed eye diseases was calculated. Hierarchical multiple logistic regression models were fit to test gender differences.

Results
Women were more likely to report visual impairment (crude OR = 1.6 [95% CI: 1.56–1.74]). Prevalence of diagnosed cataract was higher among visually impaired women (crude OR = 1.4 [95% CI: 1.25–1.67]) whereas undiagnosed eye disease (crude OR = 0.7 [95% CI: 0.64–0.81]) or diagnosed glaucoma (aORsex = 0.8 [95% CI: 0.65–0.93]) were more frequent among visually impairment men. These associations were not explained by age or educational level.

Conclusions
Strong gender inequalities were observed, with a higher prevalence of visual impairment and related cataracts among women, which could be related to gender inequalities in access to health care, and undiagnosed eye disease and related glaucoma among men, which could be related to their gender socialization resulting in less frequent and effectively use of health care services.
Comparing Estimates of Fall-Related Mortality Incidence Among Older Adults in the United States
Authors: Lohman Matthew C , Sonnega Amanda J , Nicklett Emily J , Estenson Lillian , Leggett Amanda N 
Published: October 2018

AbstractBackgroundFalls are the leading cause of injury-related mortality among older adults in the United States, but incidence and risk factors for fall-related mortality remain poorly understood. This study compared fall-related mortality incidence rate estimates from a nationally representative cohort with those from a national vital record database and identified correlates of fall-related mortality.MethodsCause-of-death data from the National Death Index (NDI; 1999–2011) were linked with eight waves from the Health and Retirement Study (HRS), a representative cohort of U.S. older adults (N = 20,639). Weighted fall-related mortality incidence rates were calculated and compared with estimates from the Centers for Disease Control and Prevention (CDC) vital record data. Fall-related deaths were identified using International Classification of Diseases (Version 10) codes. Person-time at risk was calculated from HRS entry until death or censoring. Cox proportional hazards models were used to identify individual-level factors associated with fall-related deaths.ResultsThe overall incidence rate of fall-related mortality was greater in HRS–NDI data (51.6 deaths per 100,000; 95% confidence interval: 42.04, 63.37) compared with CDC data (42.00 deaths per 100,000; 95% confidence interval: 41.80, 42.19). Estimated differences between the two data sources were greater for men and adults aged 85 years and older. Greater age, male gender, and self-reported fall history were identified as independent risk factors for fall-related mortality.ConclusionIncidence rates based on aggregate vital records may substantially underestimate the occurrence of and risk for fall-related mortality differentially in men, minorities, and relatively younger adults. Cohort-based estimates of individual fall-related mortality risk are important supplements to vital record estimates.
Imaging tissues and cells beyond the diffraction limit with structured illumination microscopy and Bayesian image reconstruction
Authors: Pospíšil Jakub , Lukeš Tomáš , Bendesky Justin , Fliegel Karel , Spendier Kathrin , Hagen Guy M 
Published: October 2018

Abstract

Background
Structured illumination microscopy (SIM) is a family of methods in optical fluorescence microscopy that can achieve both optical sectioning and super-resolution effects. SIM is a valuable method for high-resolution imaging of fixed cells or tissues labeled with conventional fluorophores, as well as for imaging the dynamics of live cells expressing fluorescent protein constructs. In SIM, one acquires a set of images with shifting illumination patterns. This set of images is subsequently treated with image analysis algorithms to produce an image with reduced out-of-focus light (optical sectioning) and/or with improved resolution (super-resolution).

Findings
Five complete, freely available SIM datasets are presented including raw and analyzed data. We report methods for image acquisition and analysis using open-source software along with examples of the resulting images when processed with different methods. We processed the data using established optical sectioning SIM and super-resolution SIM methods and with newer Bayesian restoration approaches that we are developing.

Conclusions
Various methods for SIM data acquisition and processing are actively being developed, but complete raw data from SIM experiments are not typically published. Publically available, high-quality raw data with examples of processed results will aid researchers when developing new methods in SIM. Biologists will also find interest in the high-resolution images of animal tissues and cells we acquired. All of the data were processed with SIMToolbox, an open-source and freely available software solution for SIM.
The Role of Cannabis in the Management of Inflammatory Bowel Disease: A Review of Clinical, Scientific, and Regulatory Information
Authors: Swaminath Arun , Berlin Eric P , Cheifetz Adam , Hoffenberg Ed , Kinnucan Jami , Wingate Laura , Buchanan Sarah , Zmeter Nada , Rubin David T 
Published: October 2018

Abstract
There is significant interest among patients and providers in using cannabis (marijuana) and its derivatives to treat a number of chronic illnesses, including inflammatory bowel disease. Despite the Schedule I classification of cannabis by the federal government, state governments have sought ways to make cannabis available for specific medical conditions, and some states have legalized cannabis outright. This white paper summarizes the preclinical data, clinical data, safety data, and the regulatory landscape as they apply to medical cannabis use in inflammatory bowel disease. Animal models of cannabinoid chemistry and physiology give evidence of anti-inflammatory, antidiarrheal, and nociceptive-limiting properties. Human studies have found benefit in controlling symptoms and improving quality of life, but no studies have established true disease modification given the absent improvement in biomarker profiles or endoscopic healing.
Finally, this review describes the legal, regulatory, and practical hurdles to studying the risks and benefits of medical cannabis in the United States.
10.1093/ibd/izy319_video1 izy319.video1 5852852028001
A fishing ground benthic ecosystem improved during the economic crisis
Authors: Tsikopoulou Irini , Smith Chris J , Papadopoulou Nadia K , Eleftheriadou Elena , Karakassis Ioannis 
Published: October 2018

AbstractFisheries have global socioeconomic and ecological effects. Long-term ecological studies could be beneficial to ecosystem approach management and biodiversity conservation, however, they are rare. In this study, the impacts of bottom trawling on a traditional fishing ground in the Eastern Mediterranean were addressed and an improvement in diversity metrics and ecological quality status were detected and ascribed to the Greek economic crisis. After 18 years, there was a modest increase in species richness, total abundance, and ecological status in the unaffected zone and more pronounced improvement in the trawled zone pointing at a possible link to a decrease in fishing effort. This upturn emphasized the strong link between financial activities and ecology. The present study underlines the multiple and variable effects of economy not only on countries and citizens but also on the environment and ecosystem conservation and management.
Planning and implementing sexual orientation and gender identity data collection in electronic health records
Authors: Grasso Chris , McDowell Michal J , Goldhammer Hilary , Keuroghlian Alex S 
Published: October 2018

AbstractLesbian, gay, bisexual, transgender, and queer (LGBTQ) people experience significant health disparities across the life course and require health care that addresses their unique needs. Collecting information on the sexual orientation and gender identity (SO/GI) of patients and entering SO/GI data in electronic health records has been recommended by the Institute of Medicine, the Joint Commission, and the Health Resources and Services Administration as fundamental to improving access to and quality of care for LGBTQ people. Most healthcare organizations, however, have yet to implement a system to collect SO/GI data due to multiple barriers. This report addresses those concerns by presenting recommendations for planning and implementing high-quality SO/GI data collection in primary care and other health care practices based on current evidence and best practices developed by a federally qualified health center and leader in LGBTQ health care.
Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion
Authors: Song Xiaoyu , Liu Wei , Yuan Xiao , Jiang Jiying , Wang Wanjuan , Mullen McKay , Zhao Xuannv , Zhang Yin , Liu Fusheng , Du Shihao , Rehman Adeel , Tian Ruijun , Li Jian , Frost Andra , Song Zhenwei , Green Hadiyah-Nicole , Henry Calmour , Liu Xing , Ding Xia , Wang Dongmei , Yao Xuebiao 
Published: October 2018

AbstractTumor metastasis represents the main causes of cancer-related death. Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis, but the underlying mechanisms remain less clear. Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation. CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation. ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation. The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses. Importantly, dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion, as overexpression of the persistent acetylation-mimicking or non-acetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion. Mechanistically, the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6–ACAP4 complex with plasma membrane in response to CCL18 stimulation. Thus, these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion.
Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage
Authors: Darkwah Oppong Marvin , Gembruch Oliver , Pierscianek Daniela , Köhrmann Martin , Kleinschnitz Christoph , Deuschl Cornelius , Mönninghoff Christoph , Kaier Klaus , Forsting Michael , Sure Ulrich , Jabbarli Ramazan 
Published: October 2018

ABSTRACT

BACKGROUND
Delayed cerebral ischemia (DCI) has a strong impact on outcome of patients with aneurysmal subarachnoid hemorrhage (SAH). Positive effect of antiplatelet therapy on DCI rates has been supposed upon smaller SAH series.

OBJECTIVE
To analyze the benefit/risk profile of antiplatelet use in SAH patients.

METHODS
This retrospective case–control study was based on institutional observational cohort with 994 SAH patients treated between January 2003 and June 2016. The individuals with postcoiling antiplatelet therapy (aspirin with/without clopidogrel) were compared to a control group without antiplatelet therapy. Occurrence of DCI, major/minor bleeding events in the follow-up computed tomography scans, and favorable outcome at 6 mo after SAH (modified Rankin scale < 3) were compared in both groups.

RESULTS
Of 580 patients in the final analysis, 329 patients received post-treatment antiplatelet medication. There were no significant differences between the compared groups with regard to basic outcome confounders. Aspirin use was independently associated with reduced DCI risk (P < .001, adjusted odds ratio = 0.41, 95% confidence interval 0.24-0.65) and favorable outcome (P = .02, adjusted odds ratio = 1.78, 95% confidence interval 1.06-2.98). Regarding bleeding complications, aspirin was associated only with minor bleeding events (P = .02 vs P = .51 for major bleeding events).

CONCLUSION
Regular administration of aspirin might have a positive impact on DCI risk and outcome of SAH patients, without increasing the risk for clinically relevant bleeding events. In our SAH cohort, dual antiplatelet therapy showed no additional benefit on DCI risk, but increased the likelihood of major bleeding events.
Febrile Neutropenia and Long-term Risk of Infection Among Patients Treated With Chemotherapy for Malignant Diseases
Authors: Nordvig Josefine , Aagaard Theis , Daugaard Gedske , Brown Peter , Sengeløv Henrik , Lundgren Jens , Helleberg Marie 
Published: October 2018

Abstract

Background
Febrile neutropenia (FN) is a common complication to chemotherapy, associated with increased short-term morbidity and mortality. However, the long-term outcomes after FN are poorly elucidated. We examined the long-term risk of infection and mortality rates in cancer patients with and without FN.

Methods
Patients aged &gt;16 years treated with firstline chemotherapy were followed from 180 days after initiating chemotherapy until first infection, a new treatment with chemotherapy, death, or end of follow-up. Risk factors for infections were analyzed by competing risks regression, with death or another treatment with chemotherapy as competing events. Adjusted incidence rate ratios (aIRRs) of infection and death were analyzed using Poisson regression. In analyses of mortality, infection was included as a time-updated variable.

Results
We included 7190 patients with a median follow-up (interquartile range) of 0.58 (0.20–1.71) year. A total of 1370 patients had an infection during follow-up. The aIRRs of infection were 1.86 (95% confidence interval [CI], 1.56–2.22) and 2.19 (95% CI, 1.54–3.11) for patients with 1 or &gt;1 episode of FN compared with those without FN. Mortality rate ratios were 7.52 (95% CI, 6.67–8.48) &lt;1 month after, 4.24 (95% CI, 3.80–4.75) 1–3 months after, 2.33 (95% CI, 1.63–3.35) 3–6 months after, and 1.09 (95% CI, 0.93–1.29) &gt;6 months after an infection, compared with the time before infection.

Conclusions
FN during chemotherapy is associated with a long-term increased risk of infection. Mortality rates are substantially increased for 6 months following an infection.
Does Social Exclusion Alter Sensory and Pain Thresholds in Children and Adolescents with Functional Abdominal Pain? – Results from a Preliminary Study
Authors: Gulewitsch Marco Daniel , Jusyte Aiste , Weimer Katja , Schönenberg Michael 
Published: October 2018

AbstractObjectiveFunctional abdominal pain (AP) is a prevalent issue in childhood and adolescence. The contribution of psychosocial factors in the development and maintenance of this health problem is rather unclear, and experimental studies about underlying mechanisms are lacking. This study investigates whether experimentally induced social exclusion decreases sensory and pain thresholds in children suffering from AP.SubjectsTwenty children/adolescents with AP and 22 healthy controls.MethodsChildren/adolescents participated in the Cyberball paradigm, which affects an experience of social exclusion. Thermal sensory and pain thresholds were measured before and after Cyberball.ResultsChildren/adolescents with AP showed a divergent reaction regarding their sensory threshold after social exclusion: The control group exhibited a tendency toward a decreased sensory threshold whereas the AP group remained stable. Concerning the pain threshold, no effect of social exclusion could be identified. The increase of both thresholds (“numbing”) after Cyberball was positively correlated with symptoms of mental health issues.ConclusionsThis is the first study to investigate changes in sensory and pain thresholds following painful social interactions in a sample of children/adolescents with a chronic pain condition. Results suggest that AP and control children differ in their reaction of sensory thresholds, which might indicate an altered processing of social exclusion. Replication and further methodological improvements are needed.
Building Bridges: The Journey of Alabama's Health Action Coalition
Authors: Ratcliffe Carol J. , Cheshire Michelle H. , Buckner Ellen B. , Dawson Martha A. , Berry Shaina R. , McDaniel Gretchen S. , Ladner Kathleen A. 
Published: October 2018

Abstract

AIM
The Alabama Health Action Coalition is a state coalition whose purpose is to enable access to high-quality, safe, and patient-centered health care for all Alabamians by leading change in nursing and health care.

BACKGROUND
The Alabama Health Action Coalition has four focus areas: advancing nursing education, improving nursing workforce data, promoting diversity among nursing and health care professionals, and fostering a culture of health.

METHOD
From 2012 to 2014, the Advancing Education Taskforce and Health Workforce Committee initiated processes to maximize resources, track changes in workforce data, and provide support for goal achievement.

RESULTS
Outcomes included an increase in the number of nurses with a BSN and higher degrees from 35 percent to 50 percent, nearing national averages.

CONCLUSION
Tracking of trends continues with 2016 data. This growth is particularly important in a state with a large, underserved population and high percentage of rural areas.
Chief Nursing Officer Survey: BSN and Higher Degree Initiatives in North Carolina
Authors: Schuler Mary E. , (Polly) Johnson Mary P. , Stallings Karen D. , Li Yin 
Published: October 2018

Abstract

AIM
The purpose of this study was to determine gap areas where North Carolina should implement strategies to promote the Institute of Medicine’s recommendation of an 80 percent bachelor of science workforce.

BACKGROUND
The North Carolina Action Coalition sought information about the nursing BSN and higher degree workforce and about human resource policies/strategies that promote BSN and higher degree education.

METHOD
An electronic survey was used to query 120 acute care hospital chief nursing officers over a four-year period and 100 public health chief nursing officers over a two-year period.

RESULTS
A majority of acute care and a minority of public health institutions had policies promoting BSN education. Barriers included lack of tuition reimbursement, scheduling/staffing issues, lack of local universities, and a perceived lack of value for nurses. A minority of respondents reported an 80 percent BSN workforce.

CONCLUSION
Strategies are needed statewide to support nursing academic progression.
Pathways to BSN Education: Teamwork in Ohio
Authors: Sharpnack Patricia A. , Drennen Carol , Bowles Wendy , Koffel Chris , Salvador Diane , Didion Judy 
Published: October 2018

Abstract

AIM
The Ohio Action Coalition was formed to address the key recommendations of the Institute of Medicine’s Future of Nursing report.

BACKGROUND
The Future of Nursing Campaign for Action is a national initiative to guide implementation of the recommendations in the Future of Nursing report.

METHOD
Through statewide meetings, leaders from nursing education and practice adopted a statewide competency model. Regional teams provided detailed regional gap analyses using the Ohio Nurse Competency Model and address the Institute of Medicine’s foundational pillar that nurses should achieve higher levels of education.

RESULTS
Communication among baccalaureate and community colleges and nursing practice has increased statewide as a result of this collaborative project. The teams are committed to exploring ways to standardize and develop adaptable seamless academic progression models for implementation across communities.

CONCLUSION
Ultimately, the goal is to positively impact the academic preparation of the Ohio nursing workforce.