bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demand-Side Effects of Open Innovation: The Case of Cryptocurrency Forking
Authors: Sharma Vasundhara , Agarwal Ashish , Barua Anitesh 
Published: December 2024

Many digital products follow an open-innovation model, wherein the open boundaries facilitate copying (forking) the codebase and creating new products, which may compete with the parents for user demand. Although a rich body of literature highlights the benefits of open source such as the availability of developers with diverse skill sets and accelerated innovation, the competition effects of forked products on the demand of their parents remain understudied. Using data from major cryptocurrencies and their forked products created between 2011 and 2021, we study how these entrants impact the demand for parent cryptocurrencies. We categorize cryptocurrencies as transaction or platform types. Transaction coins are primarily used for the exchange of goods and services, whereas platform coins offer additional capabilities such as hosting applications or third-party services. We find that parents with only transaction capabilities experience a negative impact on demand. Although popularity may shield the parents to a certain extent, the substitution effect is still dominant. However, popular coins with platform capabilities do not experience a decrease in demand when competing with forked entrants; an increase in smart contract transactions due to their compatibility with the competing forked products offsets the negative substitution effect observed for regular transactions. Our study underscores the competitive dynamics of open innovation and provides managerial insights for firms considering open models for product development. Our results highlight the importance of considering both substitution and complementarities when assessing the risks and benefits of the open-innovation model. This paper was accepted by Anindya Ghose, information systems. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.03132 .
Concepções de residentes em saúde sobre cuidados paliativos
Authors: Conceição Ranna Gabriele Sampaio da , Oliveira Juliana da Silva , Santos Washington da Silva , Lobo Marcio Pereira , Machado Juliana Costa , Ribeiro Daiane Brito 
Published: December 2024

Objetivo: identificar o conhecimento dos profissionais residentes em saúde sobre cuidados paliativos. Método: estudo qualitativo, realizado com 21 profissionais de um programa de residência multiprofissional na Bahia. Os dados foram coletados por meio de entrevista semiestruturada nos meses de março a julho de 2023. Para análise foi utilizado o software IRAMUTEQ® e, posteriormente, a análise de conteúdo. Protocolo de pesquisa aprovado pelo Comitê de Ética em Pesquisa. Resultados: categorizou-se os dados em cinco classes, demonstrando que muitos residentes só tiveram contato com o tema durante a residência, destacando a necessidade de incluir cuidados paliativos no currículo de graduação. Além disso, evidenciaram-se dúvidas sobre a aplicação prática dos cuidados paliativos e a necessidade de capacitação contínua dos profissionais. Conclusão: infere-se que os profissionais residentes em saúde apresentam uma lacuna no processo de formação desde a graduação até a pós-graduação em relação aos cuidados paliativos.
Menopause mouth
Authors: Stanforth Anita 
Published: December 2024

Anita Stanforth details how best to support patients experiencing the menopause. Aim The aim of this article is to provide a background to women's oral health during the menopause and how dental nurses and oral health practitioners may support their patients during this time. Objective To gain a deeper insight into oral symptoms which may manifest during the menopause and how quality of life may be affected.
Temperature-insensitive liquid level sensor based on a U-shaped cascade core-offset structure
Authors: Wang Muhua , Tong Zhengrong , Zhang Weihua , Wang Xue , Liu Danyang 
Published: December 2024

A sensor based on a U-shaped cascade core-offset structure is proposed for liquid level measurement. The cladding modes are more easily excited by the core-offset structures. The U-shaped structure leads to more energy leakage into the cladding, making the sensor more sensitive to changes in the external environment. During the experiment, fiber optic liquid level sensors with different offsets are fabricated to study the liquid level sensitivities of these sensors. The experimental results show that the liquid level sensitivity is as high as 505.4 pm/mm in the range of 0–20 mm, while the sensor exhibits insensitive characteristics in the temperature range of 20–70°C. In addition, the sensor has the advantages of high sensitivity, low cost, and compactness, which make it ideal for use as a liquid level sensor in petrochemical and other applications.
Improvement in the Sagnac-loop laser frequency stabilization
Authors: Hasegawa Taro 
Published: December 2024

The laser frequency stability locked to the D2 transition of 85Rb at 780 nm using a Doppler-free Sagnac-loop stabilization scheme has been improved. In a previous work [J. Opt. Soc. Am. B 40, 667 (2023)JOBPDE0740-322410.1364/JOSAB.482223], changes in birefringence at the absorption cell windows, influenced by the cell temperature, and in the rubidium vapor, affected by magnetic field fluctuations, significantly influenced the laser frequency stability. By aligning the polarization, the short-term stability (<10s) of the locked laser frequency was improved; however, the long-term stability remained unaffected. We attribute this long-term stability to temperature-induced changes in the optical path length of the wave plates. By removing the wave plates from the setup, the long-term stability has been successfully improved.
Mid-infrared Fourier ptychographic upconversion imaging
Authors: Zheng Tingting , Wei Zhuohang , Huang Kun , Yu Mengyao , Fang Jianan , Wen Zhaoyang , Zhang Jixi , Zeng Heping 
Published: December 2024

The frequency upconversion technique offers an appealing approach for sensitive mid-infrared (MIR) imaging at room temperature. However, the spatial resolution of the upconversion imager has been notoriously restricted by the limited transverse section of the involved nonlinear crystal at the Fourier plane. Here, we implement a wide-field and high-resolution MIR upconversion imaging system based on elliptical pumping and Fourier ptychography. Specifically, an elliptical pump beam is engineered to accommodate the narrow aperture of chirped-poling crystals, thus facilitating the acquisition of high-spatial-frequency components in the lateral direction. Such an elliptical passband in the Fourier space is then discretely rotated to generate a sequence of upconversion images, which allows computational recovery of a high-resolution object image through a combination of synthetic aperture and phase retrieval operations. Consequently, an enhanced spatial resolution of 39 µm is achieved within a field of view about 25 mm, which corresponds to a space-bandwidth product of 3.2×105, over tenfold larger than previously demonstrated values. Moreover, the MIR upconversion imager can operate under a low-light illumination of one photon/pulse/pixel. Therefore, the presented paradigm of nonlinear Fourier ptychography paves the way toward high-throughput infrared imaging with massive resolvable elements and single-photon sensitivity, which would stimulate a variety of applications such as industry inspection and biomedical diagnosis.
Conditional cash transfers and mortality in people hospitalised with psychiatric disorders: A cohort study of the Brazilian Bolsa Família Programme
Authors: Bonfim Camila , Alves Flávia , Fialho Érika , Naslund John A. , Barreto Maurício L. , Patel Vikram , Machado Daiane Borges 
Published: December 2024

Background
Psychiatric patients experience lower life expectancy compared to the general population. Conditional cash transfer programmes (CCTPs) have shown promise in reducing mortality rates, but their impact on psychiatric patients has been unclear. This study tests the association between being a Brazilian Bolsa Família Programme (BFP) recipient and the risk of mortality among people previously hospitalised with any psychiatric disorders.

Methods and findings
This cohort study utilised Brazilian administrative datasets, linking social and health system data from the 100 Million Brazilian Cohort, a population-representative study. We followed individuals who applied for BFP following a single hospitalisation with a psychiatric disorder between 2008 and 2015. The outcome was mortality and specific causes, defined according to International Classification of Diseases 10th Revision (ICD-10). Cox proportional hazards models estimated the hazard ratio (HR) for overall mortality and competing risks models estimated the HR for specific causes of death, both associated with being a BFP recipient, adjusted for confounders, and weighted with a propensity score. We included 69,901 psychiatric patients aged between 10 and 120, with the majority being male (60.5%), and 26,556 (37.99%) received BFP following hospitalisation. BFP was associated with reduced overall mortality (HR 0.93, 95% CI 0.87,0.98, p 0.018) and mortality due to natural causes (HR 0.89, 95% CI 0.83, 0.96, p < 0.001). Reduction in suicide (HR 0.90, 95% CI 0.68, 1.21, p = 0.514) was observed, although it was not statistically significant. The BFP’s effects on overall mortality were more pronounced in females and younger individuals. In addition, 4% of deaths could have been prevented if BFP had been present (population attributable risk (PAF) = 4%, 95% CI 0.06, 7.10).

Conclusions
BFP appears to reduce mortality rates among psychiatric patients. While not designed to address elevated mortality risk in this population, this study highlights the potential for poverty alleviation programmes to mitigate mortality rates in one of the highest-risk population subgroups.
Next-generation sequencing guides the treatment of severe community-acquired pneumonia with empiric antimicrobial therapy failure: A propensity-score-matched study
Authors: Zhao Yuhao , Wang Yajuan , Li Yi , Song Chao , Pan Pinhua 
Published: December 2024

Background
Next-generation sequencing (NGS) is a promising diagnostic tool for pathogens diagnosis. The aim of this study is to evaluate the application of NGS-based antimicrobial therapy on clinical outcomes in severe community-acquired pneumonia (SCAP) patients with empiric antimicrobial therapy failure.

Methodology
We performed a multi-center, retrospective cohort of SCAP patients with initial empiric therapy failure. Propensity score (PS) matching was used to obtain balance among the baseline variables in NGS group (n = 82) and conventional group (n = 82). We compared the diagnostic performance of NGS with conventional microbial culture. We also compared the impact of NGS-based antimicrobial therapy on the prognosis of patients with empirical antimicrobial therapy failure.

Results
The positive rate of NGS was higher than that of conventional pathogen detection methods (92.6% vs. 74.7%, P = 0.001). Compared to the conventional group, the NGS group has a considerably higher modifications rate of antibiotic treatment (73.2% vs. 54.9%, P = 0.015). The mortality of NGS group was significantly lower than that of conventional group (28.0% vs. 43.9%, P = 0.034). Moreover, the detection of NGS can significantly shorten the ventilation time (P = 0.046), and reduce the antibiotic cost (P = 0.026).

Conclusions
NGS is a valuable tool for microbial identification of SCAP patient with initial empiric therapy failure.
Preparing for the next pandemic: Reflections and recommendations from Florida
Authors: Liu Anicca , Waldman Rachel N. , Deal Bonnie , Duff Johnathan , Batycki Jacob N. , Pretto Ernesto A. , Saavedra Jorge , Szapocznik José 
Published: December 2024

Context
The COVID-19 emergency warrants reflection on how to improve future infectious disease pandemic preparedness and response (PPR). U.S. States took diverse approaches to COVID-19, with Florida’s approach characterized by fewer restrictions on businesses and individuals. Despite the profound effects of the pandemic, there is a dearth of stakeholder-informed recommendations for PPR at the state level. This study aims to empirically examine stakeholder perspectives on PPR in Florida.

Methods
25 semi-structured interviews were conducted with former and current leaders from government, academia, and the private sector in Florida. Participants were asked about challenges encountered during COVID-19 and considerations for what should be done for future pandemics. Interview transcripts and notes were analyzed using qualitative content analysis (QCA).

Findings
Results were organized into four main categories (recommendations for future actions, challenges in PPR, successes and failures during the COVID-19 response), across which six sub-categories were identified: public health systems capacities; mitigation of disease transmission; roles and relationships; messaging and information dissemination; minimizing other adverse effects of a pandemic; and public health culture. Considering the neglect of existing pandemic plans and jurisdictional tensions around decision-making during COVID-19, participants proposed implementing a pandemic playbook that delineates the responsibilities of relevant agencies and processes of waiving standard procedures. While many suggested closures and restrictions to avoid the spread of disease, others questioned the extent to which such strategies should be implemented.

Conclusions
This study corresponds with the need for consensus-building across ideological divisions, revealing tensions among federal, state, and county-level entities, as well as across state-level agencies. Participants defined successful pandemic response as not only comprising the mitigation of disease transmission, but also the minimization of adverse social and economic effects. Participants discussed strategies for a unified, well-coordinated approach to future pandemics that balances health and economic concerns.
ZNF503-AS2 is a promising therapeutic target and is associated with the immune microenvironment in glioma
Authors: Wu Yibo , Mu Guangjing , Li Fang , Sun Yanfei , Lin Xiaoying , Liu Xuemeng , Zhao Zhimin , Han Mingzhi , Wang Donghai , Huang Bin , Li Xingang 
Published: December 2024

Background
Glioma is the most common intracranial malignancy, and the available treatment options are poor. Long noncoding RNAs (lncRNAs) have been reported to be involved in the malignant progression of glioma. The role of ZNF503-AS2 in glioma has not been reported.

Methods
We screened ZNF503-AS2 with upregulated expression in glioblastoma (GBM) by analyzing the TCGA, CGGA and GTEx databases. Single sample gene set enrichment analysis (ssGSEA) was used to calculate the enrichment of immune cells and signaling pathways in glioma samples. Single-cell datasets were used to analyze the distribution of ZNF503-AS2. In vitro experiments were used to investigate the biological function of ZNF503-AS2.

Results
ZNF503-AS2 was highly expressed in glioma and was associated with poor prognosis, malignant progression and infiltration of immunosuppressive cells. Single-cell transcriptomic analysis showed that ZNF503-AS2 was mainly expressed in macrophages and tumor cells. Further analysis revealed that immunotherapy may have better efficacy in patients with low ZNF503-AS2 expression. In vitro experiments showed that knockdown of ZNF503-AS2 reduced the proliferation, invasion and migration ability of glioma cells, induced G2/M cell cycle arrest and promoted apoptosis.

Conclusions
ZNF503-AS2 might be a valuable biomarker for predicting the prognosis of glioma patients and a potential target for glioma therapy.
The impact of screen time and social media on youth self-harm behaviour and suicide: A protocol for a systematic reviews
Authors: Gillespie Kerri M. , Branjerdporn Grace , Woerwag Mehta Sabine , Glegg Jasmyn , Porter Matthew , Bartlett Selena E. 
Published: December 2024

Introduction
Social media, gaming, and other types of screen time have been associated with a number of child and adolescent mental health concerns, including NSSI, suicidal ideation, suicide attempts and suicides. However, findings have been complicated by a quickly changing technological landscape and the COVID-19 pandemic. Inconsistent findings may be related to the dissimilar impacts of different screen time types on different age groups. The aim of this systematic review is to explore the pattern of impact of different screen time types on children and adolescents, investigating age groups of particular risk, and synthesising outcomes, recommendations, and strategies described to inform future studies and guidelines.

Methods and analysis
A systematic review will be conducted of all study types, and reported using the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. The following databases will be searched for relevant publications: CINAHL, PubMed, Embase, PsycINFO, PsychArticles, Scopus, and Web of Science. Searches will be limited by language (English). Article selection, quality evaluation, and data extraction will be conducted independently by two reviewers. Quality assessment will be conducted using Joanna Briggs Institute (JBI) checklists for the appropriate study type.

Ethics and dissemination
Ethics approval is not required since we are not using patient data. Findings will be published in a peer-reviewed journal article, and disseminated via conference presentations.

PROSPERO registration number
CRD42023493058.
Experiences of labor-intensive procedures in the management of nocturnal enuresis—an explorative interview study in children and parents
Authors: Borgström Malin , Hjelm Katarina , Skogman Barbro H. , Nevéus Tryggve , Tunebjer Maria 
Published: December 2024

Introduction
Nocturnal enuresis is a very common and socially distressing condition among children. There are qualitative studies published in children with bowel and bladder problems with a focus on health-related quality of life and the burden of the condition, but there is a lack of knowledge of the experience of managing the treatment procedures at home. From a clinical viewpoint, it can be assumed that the procedures entail a lot of work and have an impact on everyday life apart from the disorders per se, but the actual voices of the children have not been heard.

Purpose
To explore children’s and their parents’ experiences of labor-intensive procedures in the management of enuresis.

Design and methods
A qualitative interview study. Semi-structured interviews were held with fourteen children with enuresis six to nine years of age, together with their parents in Sweden between April 2020 and February 2021. Data were analyzed inductively with qualitative content analysis.

Results
The major findings showed both favorable strategies and challenges in labor-intensive management. The results are described in four categories: 1) experiences of how to manage; 2) managing procedures was a favorable experience; 3) managing procedures made it complicated and 4) problematic to remember.

Conclusion
Managing the treatment of enuresis at home can be challenging. There were procedures that children did not like and new routines that were difficult to remember. However, the study can suggest strategies in how to manage and overcome these difficulties.
GLP-1RA improves diabetic renal injury by alleviating glomerular endothelial cells pyrotosis via RXRα/circ8411/miR-23a-5p/ABCA1 pathway
Authors: Wu Weixi , Wang Yao , Shao Xian , Huang Shuai , Wang Jian , Zhou Saijun , Liu Hongyan , Lin Yao , Yu Pei 
Published: December 2024

Background
Lipotoxicity has been implicated in diabetic kidney disease (DKD). However, the role of high glucose levels in DKD and the underlying renal protective mechanisms of GLP-1 receptor agonists (GLP-1RAs) remain unclear.

Methods
To investigate cholesterol accumulation, pyroptosis in glomerular endothelial cells (GEnCs), and the renal protective mechanisms of GLP-1RAs, we used various techniques, including RT-qPCR, Oil Red O staining, Western blotting, lactate dehydrogenase (LDH) activity assays, circRNA microarrays, bioinformatics analysis, gain and loss-of-function experiments, rescue experiments, and luciferase assays. Additionally, in vivo experiments were conducted using C57BL/6J and ApoE-deficient (ApoE-/-) mice.

Results
GEnCs exposed to high glucose exhibited reduced cholesterol efflux, which was accompanied by downregulation of ATP-binding cassette transporter A1 (ABCA1) expression, cholesterol accumulation, and pyroptosis. Circ8411 was identified as a regulator of ABCA1, inhibiting miR-23a-5p through its binding to the 3’UTR. Additionally, higher glucose levels decreased circ8411 expression by inhibiting RXRα. GLP-1RAs effectively reduced cholesterol accumulation and cell pyroptosis by targeting the RXRα/circ8411/miR-23a-5p/ABCA1 pathway. In diabetic ApoE-/- mice, renal structure and function were impaired, with resulted in increased cholesterol accumulation and pyroptosis; however, GLP-1RAs treatment reversed these detrimental changes.

Conclusions
These findings suggest that the RXRα/circ8411/miR-23a-5p/ABCA1 pathway mediates the contribution of high glucose to lipotoxic renal injury. Targeting this pathway may represent a potential therapeutic strategy for patients with DKD and hypercholesterolemia. Moreover, GLP-1RAs may provide renal protective effects by activating this pathway.
Breve Histórico e Fundamentos da Análise Bioenergética
Authors: Pacheco Maria Eniana Araújo Gomes , Oliveira Gislene Farias de 
Published: December 2024

A análise bioenergética é uma terapia que une o trabalho do corpo e das emoções para melhorar a saúde mental e física. Desenvolvida por Alexander Lowen, essa perspectiva se inspirou nas teorias de Wilhelm Reich que enfatiza a relevância do corpo físico e também da energia vital no campo da psicoterapia. Reich foi um seguidor de Freud que postulava a importância da energia vital conhecida como “orgone” para a saúde global do indivíduo. Argumentava que as emoções reprimidas poderiam obstruir o seu fluxo repercutindo em questões, tanto mentais quanto físicas. Na década de 1950, Lowen ampliou esses conceitos ao combinar técnicas corporais com psicanálise para auxiliar os pacientes na liberação de tensões e emoções reprimidas. Ele enfatizava que corpo e mente estão entrelaçados. Os princípios fundamentais da análise bioenergética incluem o fluxo positivo da energia vital através do corpo para garantir bem-estar; bloqueios nesse fluxo poderiam resultar em problemas emocionais e físicos. Além disso, as tensões musculares são interpretadas como expressões de emoções guardadas, tornando-se crucial identificá-las e liberá-las. Essas pressões podem levar a dores e dificuldades emocionais para alguns indivíduos. Para aliviar essas tensões e promover o bem-estar geral das pessoas, são propostas técnicas de relaxamento, que incluem exercícios respiratórios e, movimentos corporais associados à expressão vocal, além de toques terapêuticos. Na análise bioenergética é valorizada a capacidade de se expressar com autenticidade as emoções, como um aspecto essencial para a saúde mental. O uso de exercícios corporais e intervenções psicológicas auxiliam os indivíduos no desbloqueio de suas emoções. A interconexão entre o corpo e mente é crucial nessa abordagem, dado que problemas físicos frequentemente têm raízes em traumas emocionais. Conclui-se, pois, que a terapia visa abordar o ser humano de forma integral, promovendo o desbloqueio por meio de diversas técnicas. Enfim, a análise bioenergética integra corpo e mente visando à cura e ao bem-estar, tornando-se uma abordagem significativa na psicoterapia atual.