bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Oxidative Phosphorylation–Related Genes With Deep Intracerebral Hemorrhage in Taiwan
Authors: Chen Yi-Chun , Chen Chiung-Mei , Lee Yun-Shien , Chang Kuo-Hsuan 
Published: August 2018

Background: Pathway analysis demonstrated associations between deep intracerebral hemorrhage (DICH) and the genetic risk score of complex IV of the oxidative phosphorylation (OXPHOS) pathway in whites. This study investigated the related genetic variations in the DICH population in Taiwan. Candidate variants were selected from the prior report by the following criteria: (1) nuclear genes encoding mitochondria complex IV, (2) genetic effect >1.08, (3) global minor allele frequency >0.01. Six single-nucleotide polymorphisms fitted in the selection criteria, which were mainly involved in Cox assembly, including Cox10, Cox15, and Cox18, and one structural gene, Cox7C. Associations were tested with adjustment of multiple covariables. Permutation testing of 1000 replicates was performed for empirical estimates. Results: This study enrolled 336 patients and 379 controls. Compared with whites, the Taiwan population has higher minor allele frequency (MAF) of rs4308511, rs767844, and rs221592 and lower MAF of rs8079640. There was no variation of rs16949067 in the Taiwan population. When adjusting for the traditional risk factors, rs221592 G allele was associated with DICH risk in women under additive (odds ratio (OR) = 1.5, 95% confidence interval (CI) = 1.02-2.3, P = .04) and recessive models (OR = 2.9, 95% CI = 1.2-6.9, P = .013). In an additive fashion, a poor 30-day outcome was associated with rs4308511 T allele (OR = 1.6, 95% CI = 1.1-2.3, P = .014) and rs9891372 C allele (OR = 1.7, 95% CI = 1.05-2.8, P = .024) in all subjects and in men (rs4308511, OR = 1.8, 95% CI = 1.2-2.7, P = .008; rs9891372, OR = 2.1, 95% CI = 1.1-3.8, P = .02). Conclusions: The results showed ethnic disparities in the complex IV–related genes. COX18-rs221592 G allele was associated with female DICH risks. COX7C-rs4308511 T allele was an independent risk of poor outcome in men.
Risk Factors Associated With Low Back Pain in Golfers: A Systematic Review and Meta-analysis
Authors: Smith Jo Armour , Hawkins Andrew , Grant-Beuttler Marybeth , Beuttler Richard , Lee Szu-Ping 
Published: August 2018

Context: Low back pain is common in golfers. The risk factors for golf-related low back pain are unclear but may include individual demographic, anthropometric, and practice factors as well as movement characteristics of the golf swing. Objective: The aims of this systematic review were to summarize and synthesize evidence for factors associated with low back pain in recreational and professional golfers. Data Sources: A systematic literature search was conducted using the PubMed, CINAHL, and SPORTDiscus electronic databases through September 2017. Study Selection: Studies were included if they quantified demographic, anthropometric, biomechanical, or practice variables in individuals with and without golf-related low back pain. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 3. Data Extraction: Studies were independently reviewed for inclusion by 2 authors, and the following data were extracted: characterization of low back pain, participant demographics, anthropometrics, biomechanics, strength/flexibility, and practice characteristics. The methodological quality of studies was appraised by 3 authors using a previously published checklist. Where possible, individual and pooled effect sizes of select variables of interest were calculated for differences between golfers with and without pain. Results: The search retrieved 73 articles, 19 of which met the inclusion criteria (12 case-control studies, 5 cross-sectional studies, and 2 prospective longitudinal studies). Methodological quality scores ranged from 12.5% to 100.0%. Pooled analyses demonstrated a significant association between increased age and body mass and golf-related low back pain in cross-sectional/case-control studies. Prospective data indicated that previous history of back pain predicts future episodes of pain. Conclusion: Individual demographic and anthropometric characteristics may be associated with low back pain, but this does not support a relationship between swing characteristics and the development of golf-related pain. Additional high-quality prospective studies are needed to clarify risk factors for back pain in golfers.
The effects of knee joint angle on neuromuscular activity during electrostimulation in healthy older adults
Authors: Gavin James P , Cooper Meryl , Wainwright Thomas W 
Published: August 2018

Introduction Electrostimulation devices stimulate the common peroneal nerve, producing a calf muscle-pump action to promote venous circulation. Whether knee joint angle influences calf neuromuscular activity remains unclear. Our aim was to determine the effects of knee joint angle on lower limb neuromuscular activity during electrostimulation. Methods Fifteen healthy, older adults underwent 60 min of electrostimulation, with the knee joint at three different angles (0°, 45° or 90° flexion; random order; 20 min each). Outcome variables included electromyography of the peroneus longus, tibialis anterior and gastrocnemius medialis and lateralis and discomfort. Results Knee angle did not influence tibialis anterior and peroneus longus neuromuscular activity during electrostimulation. Neuromuscular activity was greater in the gastrocnemius medialis ( p = 0.002) and lateralis ( p = 0.002) at 90°, than 0° knee angle. Electrostimulation intensity was positively related to neuromuscular activity for each muscle, with a knee angle effect for the gastrocnemius medialis ( p = 0.05). Conclusion Results suggest that during electrostimulation, knee joint angle influenced gastrocnemii neuromuscular activity; increased gastrocnemius medialis activity across all intensities (at 90°), when compared to 0° and 45° flexion; and did not influence peroneus longus and tibialis anterior activity. Greater electrostimulation-evoked gastrocnemii activity has implications for producing a more forceful calf muscle-pump action, potentially further improving venous flow.
Inherited Breast Cancer in Nigerian Women
Authors: Zheng Yonglan , Walsh Tom , Gulsuner Suleyman , Casadei Silvia , Lee Ming K. , Ogundiran Temidayo O. , Ademola Adeyinka , Falusi Adeyinka G. , Adebamowo Clement A. , Oluwasola Abideen O. , Adeoye Adewumi , Odetunde Abayomi , Babalola Chinedum P. , Ojengbede Oladosu A. , Odedina Stella , Anetor Imaria , Wang Shengfeng , Huo Dezheng , Yoshimatsu Toshio F. , Zhang Jing , Felix Gabriela E.S. , King Mary-Claire , Olopade Olufunmilayo I. 
Published: August 2018

Purpose Among Nigerian women, breast cancer is diagnosed at later stages, is more frequently triple-negative disease, and is far more frequently fatal than in Europe or the United States. We evaluated the contribution of an inherited predisposition to breast cancer in this population. Patients and Methods Cases were 1,136 women with invasive breast cancer (mean age at diagnosis, 47.5 ± 11.5 years) ascertained in Ibadan, Nigeria. Patients were selected regardless of age at diagnosis, family history, or prior genetic testing. Controls were 997 women without cancer (mean age at interview, 47.0 ± 12.4 years) from the same communities. BROCA panel sequencing was used to identify loss-of-function mutations in known and candidate breast cancer genes. Results Of 577 patients with information on tumor stage, 86.1% (497) were diagnosed at stage III (241) or IV (256). Of 290 patients with information on tumor hormone receptor status and human epidermal growth factor receptor 2, 45.9% (133) had triple-negative breast cancer. Among all cases, 14.7% (167 of 1,136) carried a loss-of-function mutation in a breast cancer gene: 7.0% in BRCA1, 4.1% in BRCA2, 1.0% in PALB2, 0.4% in TP53, and 2.1% in any of 10 other genes. Odds ratios were 23.4 (95% CI, 7.4 to 73.9) for BRCA1 and 10.3 (95% CI, 3.7 to 28.5) for BRCA2. Risks were also significantly associated with PALB2 (11 cases, zero controls; P = .002) and TP53 (five cases, zero controls; P = .036). Compared with other patients, BRCA1 mutation carriers were younger ( P < .001) and more likely to have triple-negative breast cancer ( P = .028). Conclusion Among Nigerian women, one in eight cases of invasive breast cancer is a result of inherited mutations in BRCA1, BRCA2, PALB2, or TP53, and breast cancer risks associated with these genes are extremely high. Given limited resources, prevention and early detection services should be especially focused on these highest-risk women.
Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore
Authors: Tan Amelia Li Min , Langley Sarah R , Tan Chee Fan , Chai Jin Fang , Khoo Chin Meng , Leow Melvin Khee-Shing , Khoo Eric Yin Hao , Moreno-Moral Aida , Pravenec Michal , Rotival Maxime , Sadananthan Suresh Anand , Velan S Sendhil , Venkataraman Kavita , Chong Yap Seng , Lee Yung Seng , Sim Xueling , Stunkel Walter , Liu Mei Hui , Tai E Shyong , Petretto Enrico 
Published: August 2018

AbstractContextInsulin resistance (IR) and obesity differ among ethnic groups in Singapore, with the Malays more obese yet less IR than Asian-Indians. However, the molecular basis underlying these differences is not clear.ObjectiveAs the skeletal muscle (SM) is metabolically relevant to IR, we investigated molecular pathways in SM that are associated with ethnic differences in IR, obesity, and related traits.Design, Setting, and Main Outcome MeasuresWe integrated transcriptomic, genomic, and phenotypic analyses in 156 healthy subjects representing three major ethnicities in the Singapore Adult Metabolism Study.PatientsThis study contains Chinese (n = 63), Malay (n = 51), and Asian-Indian (n = 42) men, aged 21 to 40 years, without systemic diseases.ResultsWe found remarkable diversity in the SM transcriptome among the three ethnicities, with &gt;8000 differentially expressed genes (40% of all genes expressed in SM). Comparison with blood transcriptome from a separate Singaporean cohort showed that &gt;95% of SM expression differences among ethnicities were unique to SM. We identified a network of 46 genes that were specifically downregulated in Malays, suggesting dysregulation of components of cellular respiration in SM of Malay individuals. We also report 28 differentially expressed gene clusters, four of which were also enriched for genes that were found in genome-wide association studies of metabolic traits and disease and correlated with variation in IR, obesity, and related traits.ConclusionWe identified extensive gene-expression changes in SM among the three Singaporean ethnicities and report specific genes and molecular pathways that might underpin and explain the differences in IR among these ethnic groups.
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
Authors: Kelly Elizabeth , Sharma Devdutt , Wilkinson Christopher J. , Williams Robin S. B. 
Published: August 2018

ABSTRACT
Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed. Here, we explore the possibility of a diacylglycerol kinase (DGK) playing a role in regulating the effect of VPA relating to the treatment of both disorders, using the biomedical model Dictyostelium discoideum. DGK enzymes provide the first step in the phosphoinositide recycling pathway, implicated in seizure activity. They also regulate levels of diacylglycerol (DAG), thereby regulating the protein kinase C (PKC) activity that is linked to bipolar disorder-related signalling. Here, we show that ablation of the single Dictyostelium dgkA gene results in reduced sensitivity to the acute effects of VPA on cell behaviour. Loss of dgkA also provides reduced sensitivity to VPA in extended exposure during development. To differentiate a potential role for this DGKA-dependent mechanism in epilepsy and bipolar disorder treatment, we further show that the dgkA null mutant is resistant to the developmental effects of a range of structurally distinct branched medium-chain fatty acids with seizure control activity and to the bipolar disorder treatment lithium. Finally, we show that VPA, lithium and novel epilepsy treatments function through DAG regulation, and the presence of DGKA is necessary for compound-specific increases in DAG levels following treatment. Thus, these experiments suggest that, in Dictyostelium, loss of DGKA attenuates a common cellular effect of VPA relating to both epilepsy and bipolar disorder treatments, and that a range of new compounds with this effect should be investigated as alternative therapeutic agents.
This article has an associated First Person interview with the first author of the paper.
Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair
Authors: Cristo Inês , Carvalho Lara , Ponte Susana , Jacinto António 
Published: August 2018

ABSTRACT
Tissue repair is critical for the maintenance of epithelial integrity and permeability. Simple epithelial repair relies on a combination of collective cell movements and the action of a contractile actomyosin cable at the wound edge that together promote the fast and efficient closure of tissue discontinuities. The Grainy head family of transcription factors (Grh in flies; GRHL1–GRHL3 in mammals) are essential proteins that have been implicated both in the development and repair of epithelia. However, the genes and the molecular mechanisms that it controls remain poorly understood. Here, we show that Grh knockdown disrupts actomyosin dynamics upon injury of the Drosophila pupa epithelial tissue. This leads to the formation of an ectopic actomyosin cable away from the wound edge and impaired wound closure. We also uncovered that E-Cadherin is downregulated in the Grh-depleted tissue around the wound, likely as a consequence of Dorsal (an NF-κB protein) misregulation, which also affects actomyosin cable formation. Our work highlights the importance of Grh as a stress response factor and its central role in the maintenance of epithelial characteristics necessary for tissue repair through regulating cytoskeleton and E-Cadherin dynamics.
Cinematic virtual reality: Towards the spatialized screenplay
Authors: Ross Miriam , Munt Alex 
Published: August 2018

Abstract
This article considers how screenwriting might operate in the newly established medium of cinematic virtual reality (CVR). In Part One, we take a wide view of ways to consider screenwriting and development for CVR. Our approach theorizes CVR in the tradition of picture-making (or image-making) practices that can be traced within a broader history of the visual arts – from painting, to photography and contemporary art. In this way, we lay open the possibility for CVR to find diverse paths as it responds to narrative concerns rather than suggest it should merely repeat the consolidation of narrative that occurred with the transition of exploratory early cinema to the dominant Classical Hollywood system. In Part Two, our case study approach considers co-author, Miriam Ross’, CVR practice-based research to allow a discussion of the format that can be used for delivery of the CVR screenplay. Our aims are to connect a historically based spatialization of the image with the question of the spatialization of the screenplay for CVR 360-degrees media. The agenda is to expand the conversation around CVR to reflect upon, and inspire, new ways of thinking (and seeing) the potential for the development of screen ideas in this medium.
Životní prostředí pohledem Bible
Authors: Nečas Jiří 
Published: August 2018

Zájem o životní prostředí ve většině křesťanských církví se vyvíjel zpočátku poněkud rozpačitě. Článek ukazuje, že Bible vede k environmentální odpovědnosti. Odvolává se při tom na různá místa z Bible. Zdůrazňuje, že křesťan se musí angažovat pro dobro, přičemž životní prostředí je pro křesťana součástí dobrého božího stvořitelského díla.
Modeling of Total Phenolic contents in Various Tea samples by Experimental Design Methods
Authors: Eruygur Nuraniye , Dincel Nazire Gulsah Kutuk , Kutuk Nursah 
Published: August 2018

Abstract
Tea, from the old ages to the day, is widely consumed both for enjoyment and health care due to its positive effects. The consumption of these products is increasing day by day as a result of the clear presentation of the fact that tea contains high amount of antioxidant substances (such as phenolic compounds), which is important in prevention and treatment of diseases. Tea beverage is a very important source of polyphenols. In this study, phenolic content and antioxidant capacity of different tea species were calculated by modeling with experimental design method. In the experimental part, polyphenol content was determined using the Folin-Ciocalteu method. The total amount of phenolic substance content was examined by Box-Behnken design and response surface method on black tea, green tea and white tea on different extraction temperature, extraction time and solid / liquid ratio. Solid / liquid ratio was found to be the most important parameter in terms of polyphenol content extraction from different tea samples. The highest polyphenol amount (411.762 mg gallic acid / mL) was found in green tea. To the best of our knowledge, this is the first data presenting comparatively study the effect of extraction condition on amounts of phenolic compounds from different tea samples.
Excitation functions of proton induced reactions of some radioisotopes used in medicine
Authors: Noori Susan Shukur , Akkurt İskender , Demir Nurdan Karpuz 
Published: August 2018

AbstractThe main purpose of this study is the investigation of a cross section of proton induced nuclear reactions. The excitation functions of the reactions:56Fe(p,2n)55Co58Fe(p,2n)57Co,111Cd(p,2n)110In,112Cd(p,2n)111In,125Te(p,2n)124I,126Te(p,2n)125I,68Zn(p,2n)67Gawere investigated. These reactions were studied as the resulting radioisotopes are used in medical applications. Theoretical excitation functions have been calculated with TALYS 1.6 nuclear reaction simulation code. The calculated excitation functions are compared with the experimental data.
Free amino acids in Viola tricolor in relation to different habitat conditions
Authors: Dziągwa-Becker Magdalena , Weber Ryszard , Zajączkowska Olga , Oleszek Wiesław 
Published: August 2018

Abstract
The purpose of this study was to establish the free amino acids profile of Viola tricolor collected from different habitats in Poland. Viola tricolor (heartsease) is a very popular plant found worldwide, classified both as weed and medicinal plant. Based on a validated method, the following nineteen free amino acids were analyzed using liquid chromatography-electrospray ionization coupled to a triple quadrupole mass spectrometer (LC-ESI-MS/MS):alanine, glycine, leucine, valine, isoleucine, proline, phenylalanine, tryptophan, tyrosine, serine, threonine, methionine, asparagine, glutamine, lysine, arginine, histidine, aspartic acid, glutamic acid. The total free amino acids (TAA) ranged from 9938.0 to 11393.8 mg/kg of fresh weight. The variability of the investigated amino acids with respect to different habitat conditions was statistically assessed using the method of discriminant and cluster analysis. Alanine, valine, glutamine and aspartic acid were the most abundant free amino acids present in both localizations. The ratio of total essential amino acids (EAA) to TAA was 0.27 and 0.11 in Zagródki and Wrocław, respectively. Discriminant analysis has demonstrated that the investigated habitats significantly differentiated the free amino acids content of Viola tricolor. Only methionine showed a similar concentration in both Viola tricolor populations.
Analytic approximate solutions to the chemically reactive solute transfer problem with partial slip in the flow of a viscous fluid over an exponentially stretching sheet with suction/blowing
Authors: Ene Remus-Daniel , Bordeaşu Ilare , Negrea Romeo Iosif 
Published: August 2018

Abstract
This paper analytically investigates the flow as well as the chemically reactive solute transfer problem in a viscous fluid. The motion equations are reduced to a nonlinear ordinary differential equations system using the similarity transformations. The obtained nonlinear differential system is for the first time approximately solved by means of the Optimal Homotopy Asymptotic Method (OHAM). The effects of the partial slip and suction/blowing parameters are analytically analyzed. Some examples are given; the obtained results provides us with a good agreement with the numerical results and reveal that our procedure is effective, accurate and easy to use.
Connected Domination Polynomial of Graphs
Authors: Mojdeh D. A. , Emadi A. S. 
Published: August 2018

Abstract
Let G be a simple graph of order n. The connected domination polynomial of G is the polynomial

$D_c \left( {G,x} \right) = \sum\nolimits_{i = \gamma _c \left( G \right)}^{\left| {V\left( G \right)} \right|} {d_c \left( {G,i} \right)x^i }$

, where dc(G,i) is the number of connected dominating sets of G of size i and γc(G) is the connected domination number of G. In this paper we study Dc(G,x) of any graph. We classify many families of graphs by studying their connected domination polynomial.
Generalized Weighted Ostrowski, Trapezoid and Grüss Type Inequalities on Time Scales
Authors: El-Deeb A. A. , Elsennary H. A. , Nwaeze Eze R. 
Published: August 2018

Abstract
In this article, using two parameters, we obtain generalizations of a weighted Ostrowski type inequality and its companion inequalities on an arbitrary time scale for functions whose first delta derivatives are bounded. Our work unifies the continuous and discrete versions and can also be applied to the quantum calculus case.
Disability Measurement in the Health and Retirement Study
Authors: Agree Emily M. , Wolf Douglas A. 
Published: August 2018

Abstract
The Health and Retirement Study (HRS) has provided extensive and detailed national data on disability since it began in 1992, and has been used extensively in studies of disability trends and trajectories. We summarize conceptual frameworks used to characterize disability and review the HRS measures of functioning, work disability, and employer accommodations. HRS survey questions have experienced changes in wording, skip logic, or other design features over the life of the study, and we comment on the analytic challenges posed by those changes. Among our conclusions are (1) work disability and benefit eligibility are important concepts that should be considered for redesign to better reflect current concepts and policy issues; (2) methodological studies of changes in wording or skip logic should be undertaken; and (3) minor additions to survey content in areas such as temporal reference periods or changes in social-participation activities would improve measurement.