bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
Authors: Matas Jose , Orrego Mario , Amenabar Diego , Infante Catalina , Tapia-Limonchi Rafael , Cadiz Maria Ignacia , Alcayaga-Miranda Francisca , González Paz L. , Muse Emilio , Khoury Maroun , Figueroa Fernando E. , Espinoza Francisco 
Published: December 2018

Abstract
Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement in focal or diffuse disease. This study aimed to assess the safety and efficacy of the intra-articular injection of single or repeated umbilical cord-derived (UC) MSCs in knee OA. UC-MSCs were cultured in an International Organization for Standardization 9001:2015 certified Good Manufacturing Practice-type Laboratory. Patients with symptomatic knee OA were randomized to receive hyaluronic acid at baseline and 6 months (HA, n = 8), single-dose (20 × 106) UC-MSC at baseline (MSC-1, n = 9), or repeated UC-MSC doses at baseline and 6 months (20 × 106 × 2; MSC-2, n = 9). Clinical scores and magnetic resonance images (MRIs) were assessed throughout the 12 months follow-up. No severe adverse events were reported. Only MSC-treated patients experienced significant pain and function improvements from baseline (p = .001). At 12 months, Western Ontario and Mc Master Universities Arthritis Index (WOMAC-A; pain subscale) reached significantly lower levels of pain in the MSC-2-treated group (1.1 ± 1.3) as compared with the HA group (4.3 ± 3.5; p = .04). Pain Visual Analog scale was significantly lower in the MSC-2 group versus the HA group (2.4 ± 2.1 vs. 22.1 ± 9.8, p = .03) at 12 months. For total WOMAC, MSC-2 had lower scores than HA at 12 months (4.2 ± 3.9 vs. 15.2 ± 11, p = .05). No differences in MRI scores were detected. In a phase I/II trial (NCT02580695), repeated UC-MSC treatment is safe and superior to active comparator in knee OA at 1-year follow-up. Stem Cells Translational Medicine 2019;8:215&224
Capturing Crows for the Protection of Threatened and Endangered Shorebird Species
Authors: Leo Brian T. , Manley Steven J. 
Published: December 2018

ABSTRACTCorvids are highly intelligent and capable of thriving in anthropogenic ecosystems. American crows (Corvus brachyrhynchos) regularly depredate threatened and endangered avian species. Live capture is a common component of crow management programs; however, crows are notoriously difficult to capture. Here, we report previously undocumented crow capture techniques, utilizing a modified goshawk (Accipiter gentilis) trap design as part of a shorebird conservation project in San Diego, California, USA, 2012–2017. A negative binomial generalized linear model showed a significant relationship between number of crows removed and number of endangered California least tern (Sternula antillarum browni) eggs predated by crows. Of the total number of crows in that analysis, 67% were removed via goshawk trap. Therefore, we attribute the same percentage of reduction in egg loss to the success of that trap type. We tested 2 goshawk trap designs that differed by number of capture chambers (single and double). Double‐chambered traps were nearly twice as effective at capturing crows compared with single‐chambered traps. We performed McNemar's χ2 tests with continuity correction to determine whether traps were more effective with the use of conspecific lure‐birds and obtained significant results for single and double‐chambered traps. The modified goshawk trap has an efficient design that can improve crow control programs, especially when constructed with 2 chambers and deployed with lure‐birds. © 2018 The Wildlife Society.
Fairness, Compulsory Vaccination, and Conscientious Objection
Authors: Giubilini Alberto 
Published: December 2018

AbstractThis chapter presents an argument for compulsory vaccination and against allowing non-medical vaccine exemptions. The argument is based on the idea that the proper aim of vaccination policies should be not only herd immunity but also a fair distribution of the burdens entailed by its realization. I argue that a fairness requirement need not and should not be constrained by a principle of liberty and a principle of least restrictive alternative. Indeed, I argue how compulsory vaccination is more successful than other types of vaccination policies at satisfying the principles of fairness, least restrictive alternative, and maximizing expected utility, once these principles have been properly understood.
The Business of Surgery
Authors: Frampton Sally 
Published: December 2018

AbstractThis chapter focuses on the financial implications of the operation for both patient and practitioner, paying particular attention to the period between 1870 and 1900 when there was increasing concern about the overuse of ovariotomy. The latter development is often read solely through changing notions of female pathology; this chapter offers a new approach to the period by situating the expansion of the operation primarily within a discourse of trade and business, which nonetheless was often gendered. The powerful financial connotations of ovariotomy were revealing not only of the ascendance of surgeons’ professional status (in which money played an implicit role) but also the pecuniary gains—and losses—that association with surgical innovation could bring.
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors
Authors: Smith David C. , Chugh Rashmi , Patnaik Amita , Papadopoulos Kyriakos P. , Wang Min , Kapoun Ann M. , Xu Lu , Dupont Jakob , Stagg Robert J. , Tolcher Anthony 
Published: December 2018

Summary
Purpose This Phase I trial evaluated the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of tarextumab (OMP-5948), a novel cross-reactive antibody which binds and selectively inhibits signaling via both Notch2 and Notch3, in adult patients with advanced malignancies. Methods Standard 3 + 3 design with tarextumab 0.5, 1, 2.5, or 5 mg/kg weekly, or 5, 7.5, or 10 mg/kg every other week, or 7.5 mg every 3 weeks. Dose-limiting toxicities (DLT) were assessed during the first 28 days. Results Forty-two patients received tarextumab (21 weekly, 15 every other week, 6 every three weeks). 2/6 subjects at the 5 mg/kg weekly dose, 2/3 at 10 mg/kg every other week, and 0/6 at 7.5 mg/kg every three weeks had a DLT. The maximum tolerated dose (MTD) was 2.5 mg/kg weekly, and 7.5 mg/kg on the every other and every three week schedules. Gastrointestinal (GI) toxicity was the most common adverse event with diarrhea (81%), fatigue (48%), nausea (45%), anorexia (38%), and vomiting (38%) and abdominal pain and constipation (24% each). Biomarker analysis showed regulation of stem cell and Notch gene signaling. Conclusion Tarextumab was generally well-tolerated at doses <2.5 mg weekly and 7.5 mg/kg every other and every third week. Diarrhea was dose-limiting above these levels, but relatively easily managed at lower doses. Inhibition of Notch pathway signaling was demonstrated at these doses. ClinicalTrials.gov Identifier: NCT01277146.
Earthquake-Induced Injuries: Retrospective Epidemiological Analysis of the 2015 Hindu Kush Earthquake in Pakistan
Authors: Ahmad Junaid , Ahmad Mokbul Morshed , Rodríguez Elena Espigares 
Published: December 2018

ABSTRACTObjectiveThe aim of this study was to analyze retrospectively the earthquake-induced injuries caused by the October 2015 Hindu Kush earthquake in Pakistan. This is the first population-based study to assess epidemiologically earthquake-induced injuries in the Hindu Kush region, one of the world’s most mountainous and seismically active regions. Unfortunately, only limited studies have investigated the earthquake-induced injuries and deaths in the region epidemiologically.MethodsThe 5 worst affected districts were selected according to the highest number of deaths and injuries recorded. A total of 1,790 injuries and 232 deaths were reported after the 2015 earthquake. In our study area, 391 persons were recorded and verified to have been injured as a result of the earthquake. We attempted to investigate all of the 391 injured people, but the final study looked at 346 subjects because the remaining 45 subjects could not be traced because of the non-availability of their complete records and their refusal to participate in the study.ResultsUsing the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD 10), we found that the highest number – 20.23% (70 of 346) – of injuries in the earthquake fall in the class of “Injuries to an unspecified part of trunk, limb, or body region (T08-T14).” The class of “Injuries to knee and lower leg (S80-S89),” which count 15.61% (54 out of 346), followed it, and “Injuries involving multiple body regions (T00-T07)” were making 14.74% of total injuries (51 out of 346).ConclusionIn times of natural disasters like earthquakes, collecting and analyzing real-time data can be challenging. Therefore, a retrospective data analysis of deaths and injuries induced by the earthquake is of high importance. Studies in these emerging domains will be crucial to initiate health policy debates and to prevent and mitigate future injuries and deaths. (Disaster Med Public Health Preparedness. 2018;13:732–739).
A general fluid–sediment mixture model and constitutive theory validated in many flow regimes
Authors: Baumgarten Aaron S. , Kamrin Ken 
Published: December 2018

We present a thermodynamically consistent constitutive model for fluid-saturated sediments, spanning dense to dilute regimes, developed from the basic balance laws for two-phase mixtures. The model can represent various limiting cases, such as pure fluid and dry grains. It is formulated to capture a number of key behaviours such as: (i) viscous inertial rheology of submerged wet grains under steady shearing flows, (ii) the critical state behaviour of grains, which causes granular Reynolds dilation/contraction due to shear, (iii) the change in the effective viscosity of the fluid due to the presence of suspended grains and (iv) the Darcy-like drag interaction observed in both dense and dilute mixtures, which gives rise to complex fluid–grain interactions under dilation and flow. The full constitutive model is combined with the basic equations of motion for each mixture phase and implemented in the material point method (MPM) to accurately model the coupled dynamics of the mixed system. Qualitative results show the breadth of problems which this model can address. Quantitative results demonstrate the accuracy of this model as compared with analytical limits and experimental observations of fluid and grain behaviours in inhomogeneous geometries.
Early Miocene shallow-water corals from La Guajira, Colombia: Part II, Mussidae–Siderastreidae and Milleporidae
Authors: Flórez Paola , Zapata-Ramírez Paula , Klaus James S. 
Published: December 2018

AbstractIn this contribution we describe and illustrate 14 coral morphospecies collected from the early Miocene Siamaná (Aquitanian–Burdigalian) and Jimol (late Burdigalian) formations of the Cocinetas Basin in La Guajira Peninsula, northern Colombia. Eleven were identified as already established species including seven genera belonging to the families Mussidae, Pocilloporidae, Poritidae, Siderastreidae, and Milleporidae; the other three remain in open nomenclature. Nine of the 11 species identified (81%) are extinct. The remaining two living species,Siderastrea sidereaandMillepora alcicornis, are common on modern Caribbean reefs. Their presence in the Siamaná Formation extends their temporal range in the Caribbean region to the early Miocene. Most of the taxa described here were hermatypic and zooxanthellate corals of the order Scleractinia, with the exception of the fire coralMillepora alcicornis, of the order Anthothecata, family Milleporidae. The coral fauna recorded in the Siamaná and Jimol formations is typical of shallow and calm waters of the Oligocene–Miocene transition.
Sylvan Memories of People, Place, and Trees in Nangodi, Northeastern Ghana
Authors: Renne Elisha P. 
Published: December 2018

AbstractPeople's relationships with trees reflect the landscape histories associated with distinctive forms of political and religious authority and the moral imaginings of people in Nangodi and its environs in the Upper East Region of Ghana. Their memories of particular trees serve as historical evidence of overlapping yet specific forms of political authority exercised by chiefs, earth priests, past colonial officers, and present-day Ghanaian government officials. In Nangodi, individual family ancestral tree shrines, clan tree cemeteries, and sacred groves associated with earth priests and chiefs coexist with the Red Volta West Forest Reserve and with a succession of tree-related development initiatives. While these relationships are often considered as separate claims to political authority, spiritual power, or scientific knowledge, this paper argues that these relationships of people and of trees are better conceptualized as historical accumulations that represent intersecting and contested forms of authority and political rule continuing into the present. Indigenous tree species such as ebony are associated with sacred groves controlled by chiefs, silk-cotton trees with earth priests’ cemeteries, and baobab trees with particular families coexist with foreign teak trees associated with colonial forestry. This situation suggests how institutions of governance as well as the actions of individuals have environmental consequences. A consideration of historical memories of people and trees in places such as Nangodi enables a rethinking of political and environmental dichotomies, and complicates the social dynamics of` the preservation and destruction of trees and forests around the world.
Dynamics of Outgassing and Plume Transport Revealed by Proximal Unmanned Aerial System (UAS) Measurements at Volcán Villarrica, Chile
Authors: Liu Emma J. , Wood Kieran , Mason Emily , Edmonds Marie , Aiuppa Alessandro , Giudice Gaetano , Bitetto Marcello , Francofonte Vincenzo , Burrow Steve , Richardson Thomas , Watson Matthew , Pering Tom D. , Wilkes Thomas C. , McGonigle Andrew J. S. , Velasquez Gabriela , Melgarejo Carlos , Bucarey Claudia 
Published: December 2018

AbstractVolcanic gas emissions are intimately linked to the dynamics of magma ascent and outgassing and, on geological time scales, constitute an important source of volatiles to the Earth's atmosphere. Measurements of gas composition and flux are therefore critical to both volcano monitoring and to determining the contribution of volcanoes to global geochemical cycles. However, significant gaps remain in our global inventories of volcanic emissions, (particularly for CO2, which requires proximal sampling of a concentrated plume) for those volcanoes where the near‐vent region is hazardous or inaccessible. Unmanned Aerial Systems (UAS) provide a robust and effective solution to proximal sampling of dense volcanic plumes in extreme volcanic environments. Here we present gas compositional data acquired using a gas sensor payload aboard a UAS flown at Volcán Villarrica, Chile. We compare UAS‐derived gas time series to simultaneous crater rim multi‐GAS data and UV camera imagery to investigate early plume evolution. SO2 concentrations measured in the young proximal plume exhibit periodic variations that are well correlated with the concentrations of other species. By combining molar gas ratios (CO2/SO2 = 1.48–1.68, H2O/SO2 = 67–75, and H2O/CO2 = 45–51) with the SO2 flux (142 ± 17 t/day) from UV camera images, we derive CO2 and H2O fluxes of ~150 t/day and ~2,850 t/day, respectively. We observe good agreement between time‐averaged molar gas ratios obtained from simultaneous UAS‐ and ground‐based multi‐GAS acquisitions. However, the UAS measurements made in the young, less diluted plume reveal additional short‐term periodic structure that reflects active degassing through discrete, audible gas exhalations.
Investigating the Accuracy, Precision, and Cooling Rate Dependence of Laboratory‐Acquired Thermal Remanences During Paleointensity Experiments
Authors: Santos C. N. , Tauxe L. 
Published: December 2018

AbstractWe examine the behavior of natural basaltic and trachytic samples during paleointensity experiments on both the original and laboratory‐acquired thermal remanences and characterize the samples using proxies for domain state including curvature (k) and the bulk domain stability parameters of Paterson (2011,https://doi.org/10.1029/2011JB008369) and Paterson et al. (2017,https://doi.org/10.1073/pnas.1714047114), respectively. A curvature value of 0.164 (suggested by Paterson, 2011,https://doi.org/10.1029/2011JB008369) as a critical threshold that separates single‐domain‐like remanences from multidomain‐like remanances on the original paleointensity data was used to separate samples into “straight” (single‐domain‐like) and “curved” (multidomain‐like) groups. Specimens from the two sample sets were given a “fresh” thermal remanent magnetization in a 70 μT field and subjected to an infield‐zerofield, zerofield‐infield (IZZI)‐type (Yu et al., 2004,https://doi.org/10.1029/2003GC000630) paleointensity experiment. The straight sample set recovered the laboratory field with high precision while the curved set had much more scattered results (70.5 ± 1.5 and 71.9 ± 5.2 μT, respectively). The average intensity of both sets for straight and curved was quite close to the laboratory field of 70 μT, however, suggesting that if experiments contain a sufficient number of specimens, there does not seem to be a large bias in the field estimate. We found that the dependence of the laboratory thermal remanent magnetization on cooling rate was significant in most samples and did not depend on domain states inferred from proxies based on hysteresis measurements and should be estimated for all samples whose cooling rates differ from that used in the laboratory.
Trans‐Dimensional Surface Reconstruction With Different Classes of Parameterization
Authors: Hawkins Rhys , Bodin Thomas , Sambridge Malcolm , Choblet Gaël , Husson Laurent 
Published: December 2018

AbstractThe use of Bayesian trans‐dimensional sampling in 2‐D and 3‐D imaging problems has recently become widespread in geophysical inversion. Its benefits include its spatial adaptability to the level of information present in the data and the ability to produce uncertainty estimates. The most used parameterization in Bayesian trans‐dimensional inversions is Voronoi cells. Here we introduce a general software, TransTessellate2D, that allows 2‐D trans‐dimensional inference with Voronoi cells and two alternative underlying parameterizations, Delaunay triangulation with linear interpolation and Clough‐Tocher interpolation, which utilize the same algorithm but result in either C0 or C1 continuity. We demonstrate that these alternatives are better suited to the recovery of smooth models, and show that the posterior probability solution is less susceptible to multimodalities which can complicate the interpretation of model parameter uncertainties.
Distribution of Areal Strain on Mercury: Insights Into the Interaction of Volcanism and Global Contraction
Authors: Peterson Georgia A. , Johnson Catherine L. , Byrne Paul K. , Phillips Roger J. 
Published: December 2018

AbstractShortening tectonic structures within Mercury's two largest geological units display a clear contrast in relief, length, and spatial density. The volcanic smooth plains units are deformed by smaller‐scale structures yet host more features per area than the older intercrater plains. Although faulting in the intercrater plains is dominantly attributed to global contraction, it has been unclear whether the smooth plains faults result from volcanic loading, global contraction, or both. We use estimates of fault length and displacement to calculate spatial variations of areal strain for each unit. We find that high strain concentrations within the smooth plains suggest that global contraction has contributed to deformation in these units. The observed contrast in morphology and spatial density of structures between units may primarily reflect differences in mechanical and/or structural characteristics of the lithosphere when faulting was initiated.
High‐Resolution Mapping of Nitrogen Dioxide With TROPOMI: First Results and Validation Over the Canadian Oil Sands
Authors: Griffin Debora , Zhao Xiaoyi , McLinden Chris A. , Boersma Folkert , Bourassa Adam , Dammers Enrico , Degenstein Doug , Eskes Henk , Fehr Lukas , Fioletov Vitali , Hayden Katherine , Kharol Shailesh K. , Li Shao‐Meng , Makar Paul , Martin Randall V. , Mihele Cristian , Mittermeier Richard L. , Krotkov Nickolay , Sneep Maarten , Lamsal Lok N. , Linden Mark ter , Geffen Jos van , Veefkind Pepijn , Wolde Mengistu 
Published: December 2018

AbstractTROPOspheric Monitoring Instrument (TROPOMI), on‐board the Sentinel‐5 Precurser satellite, is a nadir‐viewing spectrometer measuring reflected sunlight in the ultraviolet, visible, near‐infrared, and shortwave infrared. From these spectra several important air quality and climate‐related atmospheric constituents are retrieved, including nitrogen dioxide (NO2) at unprecedented spatial resolution from a satellite platform. We present the first retrievals of TROPOMI NO2 over the Canadian Oil Sands, contrasting them with observations from the Ozone Monitoring Instrument satellite instrument, and demonstrate TROPOMI's ability to resolve individual plumes and highlight its potential for deriving emissions from individual mining facilities. Further, the first TROPOMI NO2 validation is presented, consisting of aircraft and surface in situ NO2 observations, and ground‐based remote‐sensing measurements between March and May 2018. Our comparisons show that the TROPOMI NO2 vertical column densities are highly correlated with the aircraft and surface in situ NO2 observations, and the ground‐based remote‐sensing measurements with a low bias (15–30 %); this bias can be reduced by improved air mass factors.
Effects of Cross‐Sheet Density and Temperature Inhomogeneities on Magnetotail Reconnection
Authors: Lu San , Artemyev A. V. , Angelopoulos V. , Pritchett P. L. , Runov A. 
Published: December 2018

AbstractProperties of magnetic reconnection in Earth's magnetotail are determined by prereconnection current sheet characteristics. Although spacecraft observations have revealed that the spatial profiles of two important parameters, density and temperature, across the prereconnection magnetotail current sheet are inhomogeneous, the effects of the inhomogeneities on reconnection processes have received insufficient attention. Using Time History of Events and Macroscale Interactions during Substorm (THEMIS) and Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) observations, we show that the inhomogeneities are ubiquitous throughout the magnetotail. Using particle‐in‐cell simulations, we demonstrate that strong density inhomogeneity increases magnetotail reconnection rate, and strong temperature inhomogeneity further increases reconnection outflow speed (although reconnection rate does not change significantly). Overall, these inhomogeneities expedite energy conversion efficiency and secondary plasmoid formation during reconnection. As the current sheet density and temperature characteristics vary considerably with geocentric distance and time under different geospace conditions, a large variety of reconnection and postreconnection dynamics results from this dependence.