bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Social Cohesion, Resilience, and Psychological Well-Being Among Chinese Older Adults in Hawai’i
Authors: Zhang Wei , Liu Sizhe , Zhang Keqing , Wu Bei 
Published: June 2019

AbstractBackground and ObjectivesA growing body of literature indicates that neighborhood social cohesion is generally associated with lower levels of psychological distress and higher levels of life satisfaction (LS). However, very few studies have examined these relationships among Chinese older adults, the fastest growing aging population across all racial/ethnic groups in the U.S. Focusing on this population, the current study aims to examine the associations of neighborhood cohesion with psychological distress and LS as well as the mediating role of resilience and the moderating role of birth place in the associations.Research Design and MethodsOrdinary least squares regressions were applied to analyze data collected among 430 Chinese older adults aged 55 and older residing in Honolulu, Hawai’i.ResultsResults show that neighborhood social cohesion was positively associated with lower levels of psychological distress and higher levels of LS for the whole sample. The association between social cohesion and psychological distress was moderated by birth place such that the protecting effects of neighborhood cohesion on distress were only salient for the U.S.-born but not for the foreign-born. Moreover, the mediating role of resilience was identified: It contributed to more than 60% of the association between social cohesion and psychological distress, and more than 22% of the association between social cohesion and LS.Discussion and ImplicationsOur findings indicate the importance of a cohesive social environment and resilience in shaping psychological well-being and quality of life for older Chinese adults, the U.S.-born in particular, living in Honolulu, Hawai’i.
Constraining crustal structure in the presence of sediment: a multiple converted wave approach
Authors: Cunningham Erin , Lekic Vedran 
Published: June 2019

SUMMARYReceiver functions are sensitive to sharp seismic velocity variations with depth and are commonly used to constrain crustal thickness. The H–κ stacking method of Zhu & Kanamori is often used to constrain both the crustal thickness (H) and ${V_P}$/${V_S}$ ratio ($\kappa $) beneath a seismic station using P-to-s converted waves (Ps). However, traditional H–κ stacks require an assumption of average crustal velocity (usually ${V_P}$). Additionally, large amplitude reverberations from low velocity shallow layers, such as sedimentary basins, can overprint sought-after crustal signals, rendering traditional H–$\ \kappa $ stacking uninterpretable. We overcome these difficulties in two ways. When S-wave reverberations from sediment are present, they are removed by applying a resonance removal filter allowing crustal signals to be clarified and interpreted. We also combine complementary Ps receiver functions, Sp receiver functions, and the post-critical P-wave reflection from the Moho (SPmp) to remove the dependence on an assumed average crustal ${V_P}$. By correcting for sediment and combining multiple data sets, the crustal thickness, average crustal P-wave velocity and crustal ${V_P}$/${V_S}$ ratio is constrained in geological regions where traditional H–$\ \kappa $ stacking fails, without making an initial P-wave velocity assumption or suffering from contamination by sedimentary reverberations.
Interpolation for Curves in Projective Space with Bounded Error
Authors: Larson Eric 
Published: June 2019

AbstractGiven $n$ general points $p_1, p_2, \ldots , p_n \in{\mathbb{P}}^r$ it is natural to ask whether there is a curve of given degree $d$ and genus $g$ passing through them; by counting dimensions a natural conjecture is that such a curve exists if and only if $$\begin{equation*}n \leq \left\lfloor \frac{(r + 1)d - (r - 3)(g - 1)}{r - 1}\right\rfloor.\end{equation*}$$The case of curves with nonspecial hyperplane section was recently studied in [2], where the above conjecture was shown to hold with exactly three exceptions.In this paper, we prove a “bounded-error analog” for special linear series on general curves; more precisely we show that existence of such a curve subject to the stronger inequality $$\begin{equation*}n \leq \left\lfloor \frac{(r + 1)d - (r - 3)(g - 1)}{r - 1}\right\rfloor - 3.\end{equation*}$$Note that the $-3$ cannot be replaced with $-2$ without introducing exceptions (as a canonical curve in ${\mathbb{P}}^3$ can only pass through nine general points, while a naive dimension count predicts twelve).We also use the same technique to prove that the twist of the normal bundle $N_C(-1)$ satisfies interpolation for curves whose degree is sufficiently large relative to their genus, and deduce from this that the number of general points contained in the hyperplane section of a general curve is at least $$\begin{equation*}\min\left(d, \frac{(r - 1)^2 d - (r - 2)^2 g - (2r^2 - 5r + 12)}{(r - 2)^2}\right).\end{equation*}$$As explained in [7], these results play a key role in the author’s proof of the maximal rank conjecture [9].
Ranking migration cue contributions to guiding individual fibroblasts faced with a directional decision in simple microfluidic bifurcations
Authors: Pham Quang Long , Tong Anh , Rodrigues Lydia N , Zhao Yang , Surblyte Migle , Ramos Diomar , Brito John , Rahematpura Adwik , Voronov Roman S 
Published: June 2019

AbstractDirected cell migration in complex micro-environments, such as in vivo pores, is important for predicting locations of artificial tissue growth and optimizing scaffold architectures. Yet, the directional decisions of cells facing multiple physiochemical cues have not been characterized. Hence, we aim to provide a ranking of the relative importance of the following cues to the decision-making of individual fibroblast cells: chemoattractant concentration gradient, channel width, mitosis, and contact-guidance. In this study, bifurcated micro-channels with branches of different widths were created. Fibroblasts were then allowed to travel across these geometries by following a gradient of platelet-derived growth factor-BB (PDGF-BB) established inside the channels. Subsequently, a combination of statistical analysis and image-based diffusion modeling was used to report how the presence of multiple complex migration cues, including cell-cell influences, affect the fibroblast decision-making. It was found that the cells prefer wider channels over a higher chemoattractant gradient when choosing between asymmetric bifurcated branches. Only when the branches were symmetric in width did the gradient become predominant in directing which path the cell will take. Furthermore, when both the gradient and the channels were symmetric, contact guidance became important for guiding the cells in making directional choices. Based on these results we were able to rank these directional cues from most influential to the least as follows: mitosis > channel width asymmetry > chemoattractant gradient difference > and contact-guidance. It is expected that these results will benefit the fields of regenerative medicine, wound healing and developmental biology.
Pressure cycling technology for challenging proteomic sample processing: application to barnacle adhesive
Authors: Schultzhaus Janna N , Dean Scott N , Leary Dagmar H , Hervey W Judson , Fears Kenan P , Wahl Kathryn J , Spillmann Christopher M 
Published: June 2019

AbstractSuccessful proteomic characterization of biological material depends on the development of robust sample processing methods. The acorn barnacle Amphibalanus amphitrite is a biofouling model for adhesive processes, but the identification of causative proteins involved has been hindered by their insoluble nature. Although effective, existing sample processing methods are labor and time intensive, slowing progress in this field. Here, a more efficient sample processing method is described which exploits pressure cycling technology (PCT) in combination with protein solvents. PCT aids in protein extraction and digestion for proteomics analysis. Barnacle adhesive proteins can be extracted and digested in the same tube using PCT, minimizing sample loss, increasing throughput to 16 concurrently processed samples, and decreasing sample processing time to under 8 hours. PCT methods produced similar proteomes in comparison to previous methods. Two solvents which were ineffective at extracting proteins from the adhesive at ambient pressure (urea and methanol) produced more protein identifications under pressure than highly polar hexafluoroisopropanol, leading to the identification and description of >40 novel proteins at the interface. Some of these have homology to proteins with elastomeric properties or domains involved with protein-protein interactions, while many have no sequence similarity to proteins in publicly available databases, highlighting the unique adherent processes evolved by barnacles. The methods described here can not only be used to further characterize barnacle adhesive to combat fouling, but may also be applied to other recalcitrant biological samples, including aggregative or fibrillar protein matrices produced during disease, where a lack of efficient sample processing methods has impeded advancement. Data are available via ProteomeXchange with identifier PXD012730.
Postprandial insulin and nutrient concentrations in lipopolysaccharide-challenged growing pigs reared in thermoneutral and high ambient temperatures1
Authors: Campos Paulo Henrique Reis Furtado , Merlot Elodie , Renaudeau David , Noblet Jean , Le Floc’h Nathalie 
Published: June 2019

Abstract
The aim of this study was to evaluate the associated effects of ambient temperature and inflammation caused by repeated administration of Escherichia coli lipopolysaccharide (LPS) on insulin, energy, and AA metabolism. Twenty-eight pigs were assigned to one of the two thermal conditions: thermoneutral (24 °C) or high ambient temperature (30 °C). The experimental period lasted 17 d, which was divided into a 7-d period without LPS (days −7 to −1), and a subsequent 10-d LPS period (days 1 to 10) in which pigs were administered 5 repeated injections of LPS at 2-d intervals. Postprandial profiles of plasma insulin and nutrients were evaluated through serial blood samples taken on days −4 (P0), 4 (P1), and 8 (P2). Before the LPS-challenge (P0), postprandial concentrations of glucose, lactate, Gln, Ile, Leu, Phe, Tyr, and Val were greater in pigs kept at 24 °C than at 30 °C (P < 0.05). In contrast, Arg, Asp, Gly, His, and Met postprandial concentrations at P0 were lower at 24 °C than at 30 °C (P < 0.05). At both 24 and 30 °C conditions, pigs had greater postprandial concentrations of insulin (P < 0.01) and lower concentrations of NEFA (P < 0.01) and α-amino nitrogen (P < 0.05) at P1 and P2 than at P0. Compared with P0, postprandial concentrations of glucose were greater (P < 0.05) at P1 in pigs kept at 24 °C, and at P1 and P2 in pigs kept at 30 °C. At both ambient temperatures, pigs had lower (P < 0.05) postprandial concentrations of Ala, Gly, His, Ile, Leu, Pro, Ser, Thr, Trp, and Val at P1 and P2 than at P0. Arginine postprandial concentration at P1 was lower than at P0 in pigs kept at 24 °C (P < 0.05), whereas no difference was observed in pigs at 30 °C. Relative to P0, Gln and Tyr concentrations were lower at P1 and P2 in pigs kept at 24 °C (P < 0.01), whereas lower Gln concentration was observed only at P2 (P < 0.01) and lower Tyr only at P1 (P < 0.01) in pigs kept at 30 °C. Our study shows a hyperglycemic and hyperinsulinemic state in LPS-challenged pigs and a greater magnitude of this response in pigs kept at 30 °C. Furthermore, LPS caused important changes in BCAA, His, Thr, and Trp profiles, suggesting the role these AA in supporting the inflammatory response. Finally, our results suggest that LPS-induced effects on postprandial profiles of specific AA (Arg, Gln, Phe, and Tyr) may be modulated by ambient temperature.
BOARD INVITED REVIEW: The pig microbiota and the potential for harnessing the power of the microbiome to improve growth and health1
Authors: Aluthge Nirosh D , Van Sambeek Dana M , Carney-Hinkle Erin E , Li Yanshuo S , Fernando Samodha C , Burkey Thomas E 
Published: June 2019

AbstractA variety of microorganisms inhabit the gastrointestinal tract of animals including bacteria, archaea, fungi, protozoa, and viruses. Pioneers in gut microbiology have stressed the critical importance of diet:microbe interactions and how these interactions may contribute to health status. As scientists have overcome the limitations of culture-based microbiology, the importance of these interactions has become more clear even to the extent that the gut microbiota has emerged as an important immunologic and metabolic organ. Recent advances in metagenomics and metabolomics have helped scientists to demonstrate that interactions among the diet, the gut microbiota, and the host to have profound effects on animal health and disease. However, although scientists have now accumulated a great deal of data with respect to what organisms comprise the gastrointestinal landscape, there is a need to look more closely at causative effects of the microbiome. The objective of this review is intended to provide: 1) a review of what is currently known with respect to the dynamics of microbial colonization of the porcine gastrointestinal tract; 2) a review of the impact of nutrient:microbe effects on growth and health; 3) examples of the therapeutic potential of prebiotics, probiotics, and synbiotics; and 4) a discussion about what the future holds with respect to microbiome research opportunities and challenges. Taken together, by considering what is currently known in the four aforementioned areas, our overarching goal is to set the stage for narrowing the path towards discovering how the porcine gut microbiota (individually and collectively) may affect specific host phenotypes.
Immune system stimulation increases the plasma cysteine flux and whole-body glutathione synthesis rate in starter pigs1
Authors: Rakhshandeh Anoosh , de Lange Cornelis F M , Htoo John K , Gheisari Abbasali , Rakhshandeh Amanda R 
Published: June 2019

Abstract
Glutathione (GSH) is the major intracellular thiol that plays a role in numerous detoxification, bio-reduction, and conjugation reactions. The availability of Cys is thought to be the rate-limiting factor for the synthesis of GSH. The effects of immune system stimulation (ISS) on GSH levels and the GSH synthesis rate in various tissues, as well as the plasma flux of Cys, were measured in starter pigs fed a sulfur AA (SAA; Met + Cys) limiting diet. Ten feed-restricted gilts with initial body weight (BW) of 7.0 ± 0.12 kg were injected i.m. twice at 48-h intervals with either sterile saline (n = 4; ISS−) or increasing amounts of Escherichia coli lipopolysaccharide (n = 6; ISS+). The day after the second injection, pigs received a primed constant infusion of 35S-Cys (9,300 kBq/pig/h) for 5 h via a jugular catheter. Blood and tissue free Cys and reduced GSH were isolated and quantified as the monobromobimane derivatives by HPLC. The rate of GSH synthesis was determined by measurement of the specific radioactivity of GSH and tissue free Cys at the end of the infusion period. Plasma Cys and total SAA levels were reduced (16% and 21%, respectively), but plasma Cys flux was increased (26%) by ISS (P < 0.05). Immune system stimulation increased GSH levels in the plasma (48%; P < 0.05), but had no effect on GSH levels in the liver, small and large intestines, heart, muscle, spleen, kidney, lung, and erythrocytes. The fractional synthesis rate (FSR) of GSH was higher (P < 0.05) in the liver (34%), small intestine (78%), large intestine (72%), heart (129%), muscle (37%), and erythrocytes (47%) of ISS+ pigs compared to ISS− pigs. The FSR of GSH tended (P = 0.08) to be higher in the lungs (45%) of ISS+ pigs than in ISS− pigs. The absolute rate of GSH synthesis was increased by ISS (mmol/kg wet tissue/d ± SE, ISS− vs. ISS+; P < 0.05) in the liver (5.22 ± 0.22 vs. 7.20 ± 0.59), small intestine (2.54 ± 0.25 vs. 4.52 ± 0.56), large intestine (0.61 ± 0.06 vs. 1.06 ± 0.16), heart (0.21 ± 0.03 vs. 0.48 ± 0.08), lungs (1.50 ± 0.10 vs. 2.90 ± 0.21), and muscle (0.21 ± 0.03 vs. 0.34 ± 0.04), but it remained unchanged in erythrocytes, the kidney, and the spleen (P > 0.80). The current findings suggest that GSH synthesis is increased during ISS, contributing to enhanced maintenance sulfur amino acid requirements in starter pigs during ISS.
Energy values of solvent-extracted canola meal and expeller-derived canola meal for broiler chickens and growing pigs determined using the regression method1
Authors: Zhong Ruqing , Adeola Olayiwola 
Published: June 2019

Abstract
The energy values of solvent-extracted canola meal (SECM) and expeller-derived canola meal (EDCM) for broiler chickens and growing pigs were determined in 2 experiments using the regression method. Corn–soybean meal reference diet (RF) and 4 test diets were prepared. The test diets consisted of SECM or EDCM that partly replaced the energy sources in the RF at 100 or 200 g/kg, respectively. The ratios of all energy ingredients were kept similar across all experimental diets. In Exp. 1, a total of 300 birds were fed standard broiler starter diet from days 0 to 19 posthatching. On day 19, 240 birds (776 ± 79.3 g initial BW) were assigned into 5 experimental diets in a randomized complex block design with BW as a blocking factor. Excreta were collected from days 23 to 25 and ileal digesta were collected after birds were euthanized by CO2 asphyxiation on day 26. In Exp. 2, 40 barrows (28.4 ± 1.6 kg initial BW) were allotted to 5 experimental diets according to the randomized complete block design with BW as a blocking factor. After 5-d adaption period, the feces and urine samples were collected for 5 d by total collection method. The ileal digestible energy (IDE), apparent ME (AME), and nitrogen-corrected apparent ME (AMEn) in Exp. 1 and the DE, AME, and AMEn in Exp. 2 for experimental diets and canola meals were determined. In Exp. 1, the inclusion of canola meals to RF linearly decreased the IDE, AME, and AMEn for birds fed SECM diets (P < 0.01) and the AME and AMEn for birds fed EDCM diets (P < 0.01). Furthermore, quadratic effects were also found in the IDE, AME, and AMEn by the inclusion of EDCM to RF (P < 0.05). The IDE were 2,194 and 3,514 kcal/kg DM for SECM and EDCM in broiler chickens, respectively. The respective ME and MEn values were 1,919 and 1,695 kcal/kg DM for SECM and 3,134 and 2,937 kcal/kg DM for EDCM. In Exp. 2, the SECM or EDCM addition to RF linearly decreased the AME and AMEn for pigs (P < 0.01). The DE content was also decreased linearly with the increasing level of SECM (P < 0.01). The DE, ME, and MEn of SECM for pigs were 3,109, 2,891, and 2,655 kcal/kg DM, respectively. The EDCM contained 3,850 kcal of DE, 3,581 kcal of ME, and 3,491 kcal of MEn/kg DM for pigs. In conclusion, the energy values of EDCM are greater than those of SECM for broiler chickens and pigs, and pigs utilize more of the GE in SECM and EDCM than broiler chickens.
Effects of a recombinant fibrolytic enzyme on fiber digestion, ruminal fermentation, nitrogen balance, and total tract digestibility of heifers fed a high forage diet1
Authors: Ran Tao , Saleem Atef M , Shen Yizhao , Ribeiro Gabriel O , Beauchemin Karen A , Tsang Adrian , Yang Wenzhu , McAllister Tim A 
Published: June 2019

AbstractA metabolism study was conducted using 8 ruminal cannulated beef heifers to investigate the effects of a recombinant fibrolytic enzyme (RFE; xylanase XYL10C) selected specifically for forage-fed ruminants on ruminal pH, fermentation, nitrogen balance, and total tract digestibility of heifers. The experiment was a cross-over design with 2 treatments and 2 periods. The 2 treatments were a basal diet containing 60% barley silage, 30% barley straw, and 10% supplement (DM basis) without (control) or with RFE. The enzyme was sprayed onto the barley straw at a rate of 6.6 × 104 IU·kg−1 DM 24 h before feeding. Each period comprised 2 wk of diet adaptation and 1 wk of sampling and data collection. Feed intake and total tract digestibility of DM, OM, NDF, and ADF were unaffected by RFE. Ruminal pH including mean, minimum, maximum, and duration pH <5.8, did not differ between treatments. Total VFA concentration, molar proportion of individual VFA, and acetate-to-propionate ratio were also not affected by RFE. However, ruminal NH3-N concentration (P < 0.06) and endoglucanase activity (P < 0.08) in ruminal fluid tended to be higher with RFE. Nitrogen utilization and microbial protein synthesis were not affected by treatment. These results indicate that XYL10C did not improve fiber digestion in heifers fed a high forage diet, despite the fact that it was specifically selected for this trait in laboratory assays. However, the increased ruminal NH3-N concentration suggests it potentially increased ruminal proteolytic activity.
Through a Glass, Darkly: Three Important Conversations for Human Rights Professionals
Authors: Sharp Dustin N 
Published: June 2019

AbstractThe current moment in history is marked by a sense of anxiety about the future of human rights as a global project. In many instances, human rights pessimism has eclipsed a larger empirical picture of human rights progress. In assessing this paradox of perception, I argue that human rights professionals themselves contribute to this sense of pessimism and crisis in ways that can become counterproductive and demobilizing. Promoting a more positive and balanced human rights vision reflecting both progress and challenges will require several shifts in emphasis over the coming years, beginning with some neglected conversations for the broader field of human rights. These conversations relate to (1) an assessment of the ways in which the prism of professional experience has shaped the messaging and world view of human rights advocates; (2) the role of human rights critics in promoting new thinking and reform; and (3) the need for advocates to go beyond what I call the ‘legalistic referee model’ in their attempts to promote positive change.
How I Would Apply Change Principles in Psychotherapy with Three Cases of Depression
Authors: Johnson Benjamin 
Published: June 2019

Abstract
This chapter describes how the author would implement each of the empirically based principles of change identified in Chapter 2, as they are specifically related to the three cases of depression presented in Chapter 3. The chapter begins with the author’s initial reaction to the list of principles, as well as to the task of describing their implementation in his day-to-day clinical work. Also included in the chapter are the author’s case formulation and treatment for each case, which serve as the general context for the author’s detailed explanation of why and how he would apply the principles in ways that are best attuned to the needs of particular clients. The chapter ends with the description of the author’s thoughts and experience about writing this chapter.
Conceptual, Clinical, and Empirical Perspectives on Principles of Change for Depression
Authors: Johnson Benjamin , Vivian Dina , Wolf Abraham W. , Beutler Larry E. , Castonguay Louis G. , Constantino Michael J. 
Published: June 2019

Abstract
The goal of this chapter is to generate new conceptual, clinical, and empirical perspectives about principles of change that are relevant to the treatment of depression. It provides an opportunity for the authors of the previous three chapters to present their views about convergences and differences in the implementation of principles, the clinical helpfulness of these principles, the possible ways of combining them, as well as the principles that should be investigated in future research. The chapter also includes comments from the editors on each of these issues, as a way to engage conversations and/or future collaboration between researchers and clinicians.