bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Photochemical Ligation System Enabling Solid‐Phase Chemiluminescence Read‐Out
Authors: Delafresnaye Laura , Schmitt Christian W. , Barner Leonie , Barner‐Kowollik Christopher 
Published: June 2019

AbstractThe peroxyoxalate chemiluminescence (PO‐CL) reaction is among the most powerful and versatile techniques for the detection of hydrogen peroxide (H2O2) and has been employed in various biological and chemical applications over the past 50 years. However, its two‐component nature (peroxyoxalate and fluorophore) limits its use. This contribution introduces an innovative and versatile photochemical platform technology for the synthesis of inherently fluorescent PO probes by exploiting the nitrile imine‐mediated tetrazole‐ene cycloaddition (NITEC) reaction. In the presence of hydrogen peroxide, the pioneered “2‐in‐1” molecule emits either yellow or blue light, depending on tetrazole (Tz) structure. Even in the absence of base, the emitted light remains visible and H2O2 could be detected in the nanomolar range. Critically, the PO‐Tz can be readily incorporated into polymeric materials. As a first application of this promising material, a tailor‐made PO‐Tz is grafted on poly(divinylbenzene) (PDVB) particles to enable solid‐phase chemiluminescence on microspheres.
Design of an Amphiphilic Perylene Diimide for Optical Recognition of Anticancer Drug through a Chirality‐Induced Helical Structure
Authors: Zhao Hao , Hussain Sameer , Liu Xiaoyan , Li Shengliang , Lv Fengting , Liu Libing , Wang Shu 
Published: June 2019

AbstractIntroduction of chirality into a supramolecular self‐assembly system plays an indispensable role in attaining specific molecular recognition ability. Herein, a chiral anticancer drug 5′‐deoxy‐5‐fluorouridine (5′DFU) was explored for inducing the self‐assembly of a cationic perylene diimide derivative containing boronic acid groups (PDI‐PBA) into a highly ordered right‐handed helical structure. As a result, PDI‐PBA exhibited a molecular recognition ability towards 5′DFU among othercis‐diols and anticancer drugs. With the help of a dynamic covalent bond and favorable hydrogen‐bonding interactions, chirality transfer from chiral 5′DFU to achiral PDI‐PBA breaks down the strong π–π stacking of PDI‐PBA and makes it reorganize into highly ordered helical supramolecular structures. This work provides an insight into chiral anticancer drug tuning interactions of π‐chromophores and the inducement of hierarchical self‐assembly to achieve specific molecular recognition.
Syntheses, Structures, and Bonding of NgF2⋅CrOF4, NgF2⋅2CrOF4(Ng=Kr, Xe), and (CrOF4)∞
Authors: Mercier Hélène P. A. , Breddemann Ulf , Brock David S. , Bortolus Mark R. , Schrobilgen Gary J. 
Published: June 2019

AbstractThe noble‐gas difluoride adducts, NgF2⋅CrOF4and NgF2⋅2CrOF4(Ng=Kr and Xe), have been synthesized and structurally characterized at low temperatures by Raman spectroscopy and single‐crystal X‐ray diffraction. The low fluoride ion affinity of CrOF4renders it incapable of inducing fluoride ion transfer from NgF2(Ng=Kr and Xe) to form ion‐paired salts of the [NgF]+cations having either the [CrOF5]−or [Cr2O2F9]−anions. The crystal structures show the NgF2⋅CrOF4adducts are comprised of Ft−Ng−Fb‐ ‐ ‐Cr(O)F4structural units in which NgF2is weakly coordinated to CrOF4by means of a fluorine bridge, Fb, in which Ng−Fbis elongated relative to the terminal Ng−Ftbond. In contrast with XeF2⋅2MOF4(M=Mo or W) and KrF2⋅2MoOF4, in which the Lewis acidic, F4(O)M‐ ‐ ‐Fb‐ ‐ ‐M(O)F3moiety coordinates to Ng through a single M‐ ‐ ‐Fb−Ng bridge, both fluorine ligands of NgF2coordinate to CrOF4molecules to form F4(O)Cr‐ ‐ ‐Fb−Ng−Fb‐ ‐ ‐Cr(O)F4adducts in which both Ng−Fbbonds are only marginally elongated relative to the Ng−F bonds of free NgF2. Quantum‐chemical calculations show that the Cr−Fbbonds of NgF2⋅CrOF4and NgF2⋅2CrOF4are predominantly electrostatic with a small degree of covalent character that accounts for their nonlinear Cr‐ ‐ ‐Fb−Ng bridge angles and staggered O−Cr‐ ‐ ‐Fb−Ng−Ftdihedral angles. The crystal structures and Raman spectra of two CrOF4polymorphs have also been obtained. Both are comprised of fluorine‐bridged chains that arecis‐ andtrans‐fluorine‐bridged with respect to oxygen.
Potassium Salts of 2,5‐Bis(trimethylsilyl)‐Germolide: Switching between Aromatic and Non‐Aromatic States
Authors: Dong Zhaowen , Schmidtmann Marc , Müller Thomas 
Published: June 2019

AbstractThe reduction of a 1‐mesityl‐2,5‐bis‐trimethylsilylchlorogermole 8 with KC8 is reported. While the reaction with one equivalent of KC8 gave the dimer with a Ge−Ge bond 10, excess of KC8 (four equivalents) resulted in the formation of the potassium salt of the germole dianion, 11 with reductive cleavage of the Ge−C bond. Careful reduction with two equivalents of KC8 in THF provided the potassium salt of the planar germolide 5. Its solid‐state structure revealed contact ion pairs with the potassium ion η5‐coordinated to the germacyclopentadienide ring. The molecular structure of the anion indicates a high degree of cyclic electron delocalization, in agreement with results from DFT calculations. Separation of the ion pair by complexation of the potassium ions with 18‐crown‐6 triggers the isomerization to germolide 6, which is characterized by a pyramidal coordination sphere of the germanium atom and a localized diene structure. The isomers 5 and 6 represent a rare example for a structurally manifested switch between a non‐aromatic and an aromatic state induced by an external stimulus, in this case the complexation of the counter cation.
Schnelle, effiziente und kostengünstige Auslegung von Membranverfahren mit flexiblen Labormembrantestständen
Authors: Tuchborn Siegfried , Enders Mark 
Published: June 2019

AbstractBei der Auslegung komplexer Membranverfahren müssen unterschiedliche Aspekte berücksichtigt werden. Während in der Laborphase grundlegende Fragen adressiert werden, lassen sich die realen Gegebenheiten im technischen Prozess erst im Zuge einer meist aufwendigen Pilotierung untersuchen. Abhilfe schaffen Labormembranteststände, die bereits im Labor mit kleinen Versuchsmengen einen betriebsnahen Zustand abbilden können. Die Anforderung an moderne Labormembranteststände, die Anlagengestaltung sowie die Vorgehensweise bei den Laborversuchen werden vorgestellt und anhand eines Beispiels zur Rückgewinnung von Prozesswasser bei der Glycerinherstellung veranschaulicht.
Overall survival and histology‐specific subgroup analyses from a phase 3, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma
Authors: Patel Shreyaskumar , von Mehren Margaret , Reed Damon R. , Kaiser Pamela , Charlson John , Ryan Christopher W. , Rushing Daniel , Livingston Michael , Singh Arun , Seth Rahul , Forscher Charles , D'Amato Gina , Chawla Sant P. , McCarthy Sharon , Wang George , Parekh Trilok , Knoblauch Roland , Hensley Martee L. , Maki Robert G. , Demetri George D. 
Published: June 2019

BackgroundWe performed a randomized phase 3 study of trabectedin versus dacarbazine in previously‐treated patients with liposarcoma/leiomyosarcoma (LPS/LMS).MethodsPatients were randomized 2:1 to trabectedin (n = 384) or dacarbazine (n = 193) administered intravenously every 3 weeks. The primary objective was overall survival (OS). Secondary objectives were progression‐free survival, objective response rate, safety, and patient‐reported outcomes, all previously reported and demonstrating superior disease control with trabectedin. Results of the final OS analysis in preplanned subgroups of patients with LPS/LMS are presented.ResultsAt the time of the final OS analysis, 577 patients had been assigned randomly, including 423 (73%) with LMS and 154 (27%) with LPS. The median duration of treatment exposure was higher in the trabectedin arm compared with the dacarbazine arm (4 vs 2 cycles), as was the proportion of patients receiving an extended number of therapy courses (≥6 cycles: 42% vs 22%). This pattern was consistent across histological subgroups: the median number of treatment cycles (4 vs 2 for both subgroups) and proportion of patients with ≥6 treatment cycles (LMS, 43% vs 24%; LPS, 40% vs 16%). Despite improved disease control by trabectedin, no improvement in OS was observed; the final median OS for trabectedin versus dacarbazine was 13.7 versus 13.1 months (P = .49). Sensitivity analyses of OS suggest confounding by post‐study anticancer therapies, which were utilized in most patients in both treatment arms (71% vs 69%, respectively).ConclusionThe final OS results demonstrated comparable survival between LPS/LMS patients receiving trabectedin or dacarbazine, which is consistent with the interim analysis results. Both LPS and LMS demonstrated improved disease control with trabectedin.
Retracted: Smart city framework based on intelligent sensor network and visual surveillance
Authors: Cai Zhiming , Li Daming , Deng Lianbing , Yao Xiang 
Published: June 2019

SummaryIn the field of urban development, the construction of new smart cities has received the attention of the government and society. In the process of promoting urban intelligence, urban road lighting, intelligent lighting, etc, have gradually received attention, while the lighting source and control methods have been greatly improved. Smart cities portray a very good vision for development for human beings. Traditional video surveillance only provides simple functions such as video capture, storage, and playback, which are difficult to use as an early warning and alarm. To ensure that abnormal behaviors are monitored in real time and effective measures are taken in a timely manner, monitoring personnel are required to monitor the video at all times. A huge monitoring network will generate massive video data. How to efficiently extract useful information from these massive data is a problem to be solved by intelligent video surveillance technology. This paper starts with the concept of top‐level design of smart city construction and analyzes the meaning and content of top‐level design. This paper summarizes some of the misunderstandings in the current top‐level design process and provides suggestions for the top‐level design.
Cocrystals of Gallic Acid with Urea and Propionamide: Supramolecular Structures, Hirshfeld Surface Analysis, and DFT Studies
Authors: Jyothi Kanchi Lakshminarayanashetty , Gautam Raj , Swain Diptikanta , Guru Row Tayur Narasingarow , Lokanath Neratur Krishnappagowda 
Published: June 2019

AbstractThe exploitation of new crystal forms with controlled properties of the active pharmaceutical ingredients (APIs) has a significant role in the pharmaceutical industry. Cocrystallization technique is a powerful strategy to modify the physicochemical properties of APIs. In the present work, two pharmaceutical cocrystals—gallic acid‐urea (GA‐UR) and gallic acid‐propionamide (GA‐PR)—have been obtained by mechanochemical grinding method. Novel cocrystals are characterized by powder X‐ray diffraction, Fourier‐transform infrared spectroscopy, and their structures are confirmed by single crystal X‐ray diffraction method. The structural analysis confirms the formation of various supramolecular architectures. Thermal gravimetric analysis is carried out to investigate the presence of water/solvent molecules in the cocrystals. Further, the intermolecular interactions in stabilizing the cocrystals are analyzed using Hirshfeld surfaces. Furthermore, the coordinates of cocrystals are optimized by density functional theory (DFT) calculations using B3LYP hybrid functional with 6–31+G(d,p) level basis set. Frontier molecular orbitals (HOMO‐LUMO), energy gap, and related molecular properties are also analyzed.
Vertebrates are poor umbrellas for invertebrates: cross‐taxon congruence in an Australian tropical savanna
Authors: Oberprieler Stefanie K. , Andersen Alan N. , Gillespie Graeme R. , Einoder Luke D. 
Published: June 2019

AbstractInvertebrates are commonly ignored in conservation planning due to their vast diversity, difficulties with species identification, a poor understanding of their spatial patterns, and the impracticability of carrying out comprehensive sampling. Conservation planning for fauna is therefore often based on patterns of diversity and distribution of vertebrates, under the assumption that these are representative of animal diversity more generally. Here, we evaluate how well vertebrates act as umbrellas for invertebrate diversity and distribution in a highly diverse tropical savanna landscape, and we investigate the effect of vertebrate sampling intensity (i.e., number of surveys) on congruence results. We assessed congruence between each of the four classes of terrestrial vertebrates (amphibians, reptiles, birds, and mammals) and twelve invertebrate families (representing four dominant invertebrate taxa: ants, beetles, flies, and spiders) by applying a range of modeling approaches to analyze patterns of cross‐taxon congruence in species richness and composition across sampling sites. To investigate drivers of congruence, we applied generalized and distance‐based linear models to identify environmental associations of richness and composition for each taxon, then examined variation in environmental associations across taxa. Vertebrate and invertebrate richness was weakly (<30%) associated, and ~60% of the significant associations were negative. Correlations in species composition between vertebrate and invertebrate taxa were also weak, with a maximum of 13% congruence. In most cases, pairwise correlation scores using data from single surveys of vertebrates were only marginally lower than those from multiple surveys. Poor among‐site congruence between vertebrates and invertebrates was reflected by marked variation among taxa in their environmental associations. Our findings show that vertebrates are poor umbrellas for invertebrates in the tropical savannas of northern Australia in terms of geographic patterns of diversity and distribution and that this is not just an artifact of low vertebrate sampling intensity. Our study is one of the most comprehensive regional analyses of the congruence of vertebrate and invertebrate diversity, and it significantly adds to the growing evidence that empirical data on invertebrate diversity and distribution are required for conservation planning that effectively protects all faunal diversity.
Cortical morphometry in anorexia nervosa: An out‐of‐sample replication study
Authors: Leppanen Jenni , Sedgewick Felicity , Cardi Valentina , Treasure Janet , Tchanturia Kate 
Published: June 2019

AbstractBackgroundAcute anorexia nervosa (AN) is frequently accompanied by reduced global cortical volume. Investigations of local cortical alterations in AN have revealed widespread reduction in cortical thickness, gyrification, and curvature. The aim of the present study was to combine data from two previous studies to replicate previous findings.MethodologyMagnetic resonance imaging (MRI) images from 46 adult women with AN and 54 age‐matched healthy comparison (HC) women were analysed using FreeSurfer. Group differences in cortical volume and local cortical measures, including gyrification, curvature, thickness, and area, were examined controlling for dataset and age.ResultsThe AN group had reduced global cortical volume relative to the HC group. The AN group also had reduction in local cortical gyrification, small localised clusters of reduced cortical thickness, in the occipital and parietal cortices, and surface area in the frontal and temporal cortices. The AN group also had increased cortical thickness in the ACC relative to the HC participants.ConclusionsThe present findings replicate and validate previous findings of reduced global cortical volume and local gyrification in acute AN. The findings highlight the need for further investigation of local cortical folding, thickness, and surface area in AN to gain further insight into the biological underpinnings of AN.
Der Untertagebau im Baulos Prutz/Ried des Gemeinschaftskraftwerks Inn (GKI)
Authors: Wachter Robert , Bonapace Paul , Bilak Andreas 
Published: June 2019

AbstractEven in the 1920s were already the plans for hydropower exploitation of the upper River Inn. Since the resumption of design work, the Gemeinschaftskraftwerk Inn (GKI) project has been optimised and adapted to the latest state of the technology as well as ecological requirements. After a collaborative process involving the authorities from both countries, the start of construction could be approved in 2014. The project will build a diversion hydropower station with an annual generation of about 414 GWh in the border area of Switzerland and Austria.
Untere Tuxbachüberleitung – Ein Überleitungsstollen als Hochdruckstollen: Vortrieb und Auskleidungskonzept für Innendrücke über 20 bar
Authors: Blauhut Andreas , Steyrer Peter , Eichiner Hans , Fiegl Marco , Gasser Oliver , Riediger Christian 
Published: June 2019

AbstractThe ”Lower Tuxbach diversion“ project includes an 8.5 km headrace tunnel to the Stillupp reservoir. Nearly in the middle, the tunnel has to pass under the Zemm valley, which is more than 200 m deeper than the weir and the reservoir. With the shallow gradient of the TBM excavation, long sections of the tunnel will then have a high internal pressure during operation (pressure > 20 bar). The TBM excavation was carried out mainly in the Ahorn gneiss of the ”Tauernfenster“, which strikes perpendicular to the tunnel axis. The stability of the rock mass was regular, but in the tunnel section to the weir, many joints and smaller fault zones with non‐water‐resistant infilling were encountered. Considering the high internal pressure, it was decided to retain most of the originally foreseen concrete lining. In the tunnel section to the reservoir, the decision about a possible optimisation of the lining design will be made after the completion of excavation.
Geologische Grundlagen, geotechnische Planung und Auskleidung des neuen Kraftabstiegs Rodundwerk I
Authors: Gerstner Reinhold , Dich Christopher , Tschuchnigg Franz , Bickel Lukas 
Published: June 2019

AbstractIn Memoriam Reinhold GerstnerThe Vorarlberger Illwerke AG is currently working on redesigning the headrace system to the existing Rodundwerk I. The old power water way consists of an upper pressure tunnel, a penstock, a lower pressure tunnel along with the distribution pipeline to the four turbines and a pump. The same headwater sections are being constructed with an optimized route in the immediate vicinity of the existing structure. For the optimized layout of the new headrace, system options were isolated by means of 2D analyses. The variant for construction was investigated by means of a 3D analysis and the obtained results are the basis of the definition of the lining areas and thus the dimensioning of the individual types of lining. The present contribution deals with the geological boundary conditions, the findings from the old headrace, the assumptions and the resulting layout of the redesign. Finally, the basics of the lining concept and the design results are presented.
Potentially inappropriate prescribing in people with dementia: An Australian population‐based study
Authors: Eshetie Tesfahun C. , Nguyen Tuan A. , Gillam Marianne H. , Kalisch Ellett Lisa M. 
Published: June 2019

ObjectiveTo investigate the prevalence of potentially inappropriate prescribing (PIP) using the Screening Tool of Older Person's Prescriptions (STOPP) criteria in people with dementia compared with people without dementia.MethodsA retrospective cohort study was conducted using the Pharmaceutical Benefits Scheme 10% sample of pharmacy claims. People with dementia were defined as those dispensed a medicine for dementia (cholinesterase inhibitors, memantine, or risperidone for behavioural and psychological symptoms of dementia) between 1 January 2005 and 31 December 2015, aged 65 years or older at 1 January 2016 and alive at the end of 2016. An age‐ and gender‐matched comparison cohort of people not dispensed medicines for dementia was identified. PIP prevalence was determined between 1 January 2016 and 31 December 2016.ResultsIn total, 8280 people dispensed medicines for dementia and 41 400 comparisons not dispensed medicines for dementia were included: 63% were female and the median age was 82 years. PIP prevalence was 79% among people with dementia compared with 70% among the comparison group (P < .0001). Use of anticholinergics, long‐term use of high‐dose proton pump inhibitors, and use of benzodiazepines were the most common instances of PIP in people with dementia. After adjustments for age, gender, comorbidity, and number of prescribers, people with dementia were more likely to be exposed to PIP than comparisons (adjusted OR 1.44, 95% CI, 1.35‐1.53, P < .0001).ConclusionsPIP was more common in people dispensed medicines for dementia than comparisons. These results highlight the need for effective interventions to optimize prescribing in people with dementia.
LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis
Authors: Zhong Yuanbo , Wang Jin , Lv Wen , Xu Jianzhong , Mei Shanshan , Shan Aijun 
Published: June 2019

AbstractLung adenocarcinoma is the most prevalent type of lung cancer with a high incidence and mortality worldwide. Metastasis is the major cause of high death rate in lung cancer and the potential mechanism of lung adenocarcinoma metastasis remains indistinct. Emerging investigations have demonstrated that long noncoding RNA is a kind of non–protein coding RNA and plays a critical role in cancer progression and metastasis. TTN antisense RNA 1 (TTN‐AS1) has been reported to promote cell growth and metastasis in cancer. However, the function of TTN‐AS1 in lung adenocarcinoma is still to be illustrated. In this study, we observed that TTN‐AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival. TTN‐AS1 promoted cell proliferation, migration, invasion, and epithelial‐mesenchymal transition in lung cancer. TTN‐AS1 directly bound with miR‐4677‐3p and negatively regulated miR‐4677‐3p. MiR‐4677‐3p rescued the inhibitive impacts of TTN‐AS1 knockdown on lung adenocarcinoma. Furthermore, zinc finger E‐box binding homeobox 1 (ZEB1) was the target of miR‐4677‐3p, and TTN‐AS1 modulated ZEB1 by competing for miR‐4677‐3p. TTN‐AS1 drove the invasion and migration of lung adenocarcinoma cells by targeting the miR‐4677‐3p/ZEB1 axis. To sum up, our study offers insights into the mechanism of TTN‐AS1 in lung adenocarcinoma metastasis and targeting the TTN‐AS1/miR‐4677‐3p/ZEB1 axis may be the potential innovate therapeutic strategy for the patients with lung adenocarcinoma.