bluuebunny/crossref_metadata_2025_split huggingface dataset:
SHANK1 polymorphisms and SNP–SNP interactions among SHANK family: A possible cue for recognition to autism spectrum disorder in infant age
Authors: Qiu Shuang , Li Yan , Bai Ye , Shi Jikang , Cui Heran , Gu Yulu , Ren Yaxuan , Zhao Qian , Zhang Kaixin , Lu Meihan , Wang Yihan , Li Yong , Zhong Weijing , Zhu Xiaojuan , Liu Yunkai , Cheng Yi , Qiao Yichun , Liu Yawen 
Published: January 2019

Autism spectrum disorder (ASD) is a serious lifelong neurodevelopmental disorder. ASD is diagnosed for children at the age of two. ASD diagnosis, as early as possible, lays the foundation for treatment and much better prognosis. Notably, gene‐based test is an inherent method to recognize the potential infants with ASD before the age of two. To investigate whether SHANK family contributes to ASD prediction, on the basis of our previous studies of SHANK2 and SHANK3, we further investigated associations between SHANK1 polymorphisms and ASD risk as well as SNP–SNP interactions among SHANK family. We enrolled 470 subjects (229 cases and 241 healthy controls) who were northeast Chinese Han. Four tag SNPs (rs73042561, rs3745521, rs4801846, and rs12461427) of SHANK1 were selected and genotyped. We used the SNPStats online analysis program to assess the associations between the four SNPs and ASD risk. The SNP–SNP interactions among SHANK family were analyzed using multifactor dimensionality reduction method. We found that the four SHANK1 SNPs were not associated with ASD risk in northeast Chinese Han population. There existed a strong synergistic interaction between rs11236697 [SHANK2] and rs74336682 [SHANK2], and moderate synergistic interactions (rs74336682 [SHANK2]–rs73042561 [SHANK1], rs11236697 [SHANK2]–rs77716438 [SHANK2], and rs11236697 [SHANK2]–rs75357229 [SHANK2]). These SHANK1 variants may not affect the susceptibility to ASD in Chinese Han population. SNP–SNP interactions in SHANK family may confer ASD risk. Autism Res 2019, 12: 375–383 © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryASD is a serious lifelong neurodevelopmental disorder with strong genetic components. We investigated associations between SHANK1 polymorphisms and ASD risk as well as SNP–SNP interactions among SHANK family. Our results indicated that there exists no association between SHANK1 SNPs and ASD, and SNP–SNP interactions in SHANK family may confer ASD risk in the Northeast Han Chinese population. Future studies are needed to test more SHANK family SNPs in a large sample to demonstrate the associations.
Rapid detection of severe fever with thrombocytopenia syndrome virus (SFTSV) total antibodies by up‐converting phosphor technology‐based lateral‐flow assay
Authors: Huang Chao , Wei Qiaozhen , Hu Qiushi , Wen Tian , Xue Lei , Li Shuang , Zeng Xiaoyan , Shi Fengjuan , Jiao Yongjun , Zhou Lei 
Published: January 2019

AbstractIn this study, an up‐converting phosphor technology‐based lateral‐flow (UPT‐LF) assay was developed to detect severe fever with thrombocytopenia syndrome virus (SFTSV) total antibodies rapidly and specifically. SFTSV recombinant N protein (SFTSV‐rNP) was coated on analytical membrane for sample capture, up‐converting phosphor (UCP) particles were used as the reporter, the luminescence emitted by UCP particles was converted to a measurable signal by a biosensor. The performance of UPT‐LF assay was evaluated by testing 302 field serum samples by ELISA (enzyme‐linked immunosorbent assay), Western blotting and UPT‐LF assay. UPT‐LF assay exhibited a lower detection limit than ELISA, and a satisfied level of agreement was exhibited by Kappa statistics (Kappa coefficient = 0.938). Considering Western blotting as the reference for comparison, the sensitivity and specificity of UPT‐LF assay could reach 98.31% and 100%. UPT‐LF assay showed no specific reaction with hantavirus total serum antibodies, which avoids the misdiagnosis of SFTSV from hantavirus that could cause similar clinical symptoms. UPT‐LF assay was able to achieve acceptable results within 15 min and needed only 10 μL sample for each test. As a whole, UPT‐LF assay is a candidate method for on‐site surveillance of SFTSV total antibodies owing to its excellent sensitivity, specificity, stability, easy operation and for being less time consuming.
A convenient tool for bivariate data analysis and bar graph plotting with R
Authors: Hofmann Andreas , Cross Megan , Karow Malte A. , Straub Jan H. , Clemen Christoph S. , Eichinger Ludwig 
Published: January 2019

AbstractThe Java software jBar consists of a graphical user interface that allows the user to customize and assemble an included script for R. The scripted R pipeline calculates means and standard errors/deviations for replicates of numerical bivariate data and generates presentations in the form of bar graphs. A two‐sided Student's t test is carried out against a user‐selected reference and p‐values are calculated. The user can enter the data conveniently through the built‐in spreadsheet and configure the R pipeline in the graphical user interface. The configured R script is written into a file and then executed. Bar graphs can be generated as static PNG, PDF, and SVG files or as interactive HTML widgets. © 2019 International Union of Biochemistry and Molecular Biology, 47(2): 207–210, 2019.
Consumers' processing of mindful commercial car sharing
Authors: Peterson Mark , Simkins Travis 
Published: January 2019

AbstractCommercial car sharing offers a form of market‐mediated, access‐based consumption with a markedly lower impact on the natural environment than that of car ownership. Consumers adopting such alternative transportation modes are manifesting a marketplace behavior that can be said to be mindful because of the innovative and sustainable nature of car sharing. This study employs behavioral reasoning theory to examine how consumers' value orientations, as well as reasons for and against car sharing, might be used in consumers' processing of mindful commercial car‐sharing adoption. Findings suggest that subjective norms (thoughts of important others for consumers, such as co‐workers) serve an important mediating role for both consumers' value orientations and reasons for car sharing in their relationship with car‐sharing behavior. These results provide marketing researchers important knowledge about green consumption and suggest that practitioners would do well to emphasize the social dimension when marketing environmentally oriented services, such as car sharing.
Improving corporate biodiversity management through employee involvement
Authors: Boiral Olivier , Heras‐Saizarbitoria Iñaki , Brotherton Marie‐Christine 
Published: January 2019

AbstractThis paper presents an empirical examination of the role of employee involvement in the internalization of corporate biodiversity management. A qualitative study in natural resource companies was conducted, based on semi‐directive interviews with managers, consultants, and experts in this area. The findings show that employee involvement is essential to improve biodiversity practices in natural resource companies, which largely rely on organizational citizenship behaviors for the environment. The role of tacit knowledge, voluntary initiatives, and prevention of harmful behaviors in the workplace are highlighted. The main obstacles to the internalization of biodiversity issues include their complexity, the lack of corporate commitment, the externalization of initiatives, and the lack of training for employees. The contributions to the literature on corporate environmental management, internalization of new practices, and organizational citizenship behaviors for the environment are explained. Managerial implications and avenues for future research are also provided.
Nivolumab provides improved effectiveness and safety compared with docetaxel as a second‐line treatment for advanced non‐small cell lung cancer: A systematic review and meta‐analysis
Authors: Xu Zheng , Yi Fengming , Yu Dongliang , Xu Jianjun , Wei Yiping , Zhang Wenxiong 
Published: January 2019

AbstractBackgroundAs an inhibitor of programmed death‐1 (PD‐1) protein, nivolumab has been shown to be effective in various cancers. We thus conducted this meta‐analysis to compare the relative efficacy of nivolumab vs docetaxel‐based chemotherapy as a second‐line treatment for previously treated advanced non‐small cell lung cancer (NSCLC).MethodsRelevant studies were identified through searches of databases and conference proceedings. Progression‐free survival (PFS), overall survival (OS), drug responses, and adverse effects (AEs) were assessed as the primary endpoints.ResultsAfter screening, we included six studies (949 patients) in the final analysis. Nivolumab showed better efficacy in terms of the PFS (hazard ratios [HR]: 0.70, P = 0.03), OS (HR: 0.70, P < 0.00001), objective response rate (ORR) (risk ratios [RR]: 1.73, P = 0.0008), total AEs (RR: 0.77, P = 0.006), and grade 3‐5 AEs (RR: 0.18, P < 0.00001) than docetaxel. The anti‐tumor efficacy of nivolumab for NSCLC in terms of both PFS and OS was positively correlated with the level of PD‐L1 expression. In the nivolumab treatment arm, the 10 most‐reported AEs were fatigue (15.7%), nausea (10.8%), decreased appetite (10.3%), asthenia (9.8%), diarrhea (7.5%), rash (7.5%), arthralgia (5.4%), vomiting (4.4%), constipation (3.5%), and pyrexia (3.3%).ConclusionsFor advanced NSCLC, nivolumab is a better therapy in terms of both anti‐tumor efficacy and safety than docetaxel‐based chemotherapy. More high‐quality randomized controlled trials are needed to confirm these results.
Novel mutation in the MED23 gene for intellectual disability: A case report and literature review
Authors: Hashemi‐Gorji Feyzollah , Fardaei Majid , Tabei Seyed Mohammad Bagher , Miryounesi Mohammad 
Published: January 2019

Key Clinical MessageMED23 deficiency causes the autosomal recessive Intellectual Disability (ID). Here we report an Iranian case with nonsyndromic ID presenting with developmental delay, microcephaly, hypotonia, severe ID, speech delay, and spasticity, who was homozygous for the novel MED23 c.670C>G variant. These results expand the clinical and mutation spectrum of MED23 deficiency.
Dermatologic complication following axillary cannulation for aortic dissection repair
Authors: Nguyen Raisa D. , Hierlmeier Bryan J. , Kurnutala Lakshmi N. 
Published: January 2019

Key Clinical MessageIt is important to be aware of complications associated with axillary artery cannulation, especially the more common ones that can compromise limb integrity. Pulse oximeter and arterial line placed on the right upper extremity can aid in perfusion of the right arm during right axillary artery cannulation.
Highly Active Sm2O3‐Ni Xerogel Catalysts for CO2 Methanation
Authors: Ilsemann Jan , Sonström Andrea , Gesing Thorsten M. , Anwander Reiner , Bäumer Marcus 
Published: January 2019

AbstractWe report on a new synthesis route for pure Sm2O3 and Sm2O3‐Ni xerogels by modifying the well‐known epoxide addition method. The resulting xerogels are used to prove the suitability of samaria as a highly effective catalyst support and to determine the optimal Ni loading. Therefore, a set of five catalysts with Ni loadings between 4 wt % and 89 wt % Ni was prepared and fully characterized by X‐ray diffraction, N2 physisorption, transmission electron microscopy and H2 temperature‐programmed reduction. Catalytic measurements reveal that the catalyst with 39 wt % Ni shows the best catalytic performance, outperforming even highly active literature known systems. Stability runs indicate that the catalyst deactivates independently of the Ni loading as well as conversion level over 600 min due to, most likely, carbonate formation. This deactivation, however, is reversible by a simple regeneration step. As shown by simultaneous CO2/CO methanation measurements, the Ni−Sm2O3 catalysts are also highly efficient for CO methanation. In this case, CO is preferentially converted to methane compared to CO2.
Experimental Investigation and Thermodynamic Modeling of Glycerin/Methanol/Organic Solvent Systems
Authors: Mousavi Hosnie-Sadat , Rahimi Masoud , Mohadesi Majid 
Published: January 2019

AbstractGlycerin is an important by‐product in biodiesel production. To increase its quality to be suitable for use it in other operations, e.g., the pharmaceutical industry, it needs to be purified. Therefore, the purification of glycerin by liquid‐liquid extraction of methanol using different solvents was investigated. It was shown that, in terms of separation, petroleum ether was more effective than toluene and toluene was more effective than n‐butanol. In addition to the experimental investigations, the NRTL and UNIQUAC thermodynamic models were used to predict the compositions of ternary mixtures of glycerin + methanol + organic solvent in glycerin‐rich and organic solvent‐rich phases. The results showed the high accuracy of the presented models and their consistency with the measured data.
Coupling a Boron Doped Diamond Anode with a Solid Polymer Electrolyte to Avoid the Addition of Supporting Electrolyte in Electrochemical Advanced Oxidation Processes
Authors: Clematis Davide , Abidi Jihen , Cerisola Giacomo , Panizza Marco 
Published: January 2019

AbstractThe application of electrochemical technologies to wastewater treatment is limited by solution conductivity. In this paper, a solid polymer electrolyte Nafion® membrane has been used sandwiched between a boron doped diamond (BDD) anode and Ti/RuO2 cathode meshes to treat Bismarck Brown Y (BBY) solutions with very low conductivity. BBY has been chosen as model compound to the system, and the influence of several process parameters has been investigated. During the experiments the evolution of chemical oxygen demand (COD), color removal and nitrogen compounds have been monitored. The performances were strongly related with applied current and stirring rate, changed in a range of 0.5–2 A and 200 and 850 rpm, respectively. Their increment leads to a decrease of oxidation time required to remove BBY completely. The effect of the presence of Na2SO4 (2 and 7 mM) as supporting electrolyte has been also evaluated. Results were compared with a removal treatment carried out with a conventional batch system, using a flow cell containing liquid supporting electrolyte (Na2SO4). This comparison highlighted that the new cell setup is performing better in removing organic compounds, and thus, can be considered as effective process for the treatment of solutions with a low conductivity.
Hierarchical, Vertically‐Oriented Carbon Nanowall Foam Supercapacitor using Room Temperature Ionic Liquid Mixture for AC Line Filtering with Ultrahigh Energy Density
Authors: Bo Zheng , Xu Chenxuan , Yang Huachao , Shi Hao , Yan Jianhua , Cen Kefa , Ostrikov Kostya 
Published: January 2019

AbstractSupercapacitors have been considered as a promising alternative of aluminum electrolytic capacitors (AECs) for AC line filtering applications. However, realizing supercapacitors with fast frequency response and superior energy density still remains an open issue. Herein, we demonstrate a hierarchical, vertically‐oriented carbon nanowall foam (CWF) supercapacitor using mixed room temperature ionic liquids (RTILs) for high‐performance AC line filtering. Hierarchical CWF exhibits macrospores as electrolyte reservoirs to shorten ion transport distance, vertically‐oriented, open channels to enable fast ion diffusion and consecutive scaffolds to promote electron transfer. CWF supercapacitor using RTIL mixture realizes a recorded‐high areal energy density of 1.23 μWh cm−2 at 120 Hz (almost ∼2.0 times/∼10.0 times larger than those of organic/aqueous electrolytes, respectively) and fast frequency response (RC time constant=∼1.3 ms). More importantly, CWF supercapacitor achieves a capacitance advantage over commercial AECs up to 1,000 V, substantially larger than those reported in state‐of‐the‐art literatures (maximum of ∼250 V).
Facile Fabrication of Co9S8 Embedded in a Boron and Nitrogen Co‐Doped Carbon Matrix as Sodium‐Ion Battery Anode
Authors: Zhang Tianwei , Qu Hong , Sun Kuangzheng , Li Shaochun 
Published: January 2019

AbstractA unique composite (Co9S8@BNC) consisting of cobalt sulfide (Co9S8) embedded in a boron and nitrogen co‐doped carbon matrix (BNC) is successfully synthesized as anode material for sodium‐ion batteries (SIBs). The BNC matrix was demonstrated to improve the electronic and ion diffusion speed, as well as help buffer the dramatic volumetric expansion during the repeated cycling processes. Benefited from the advantages of BNC matrix, Co9S8@BNC delivered a high initial reversible capacity of 494 mAh ⋅ g−1 at 100 mA ⋅ g−1 and could remain 388 mAh ⋅ g−1 after 100 cycles. Apart from that, it exhibited an excellent rate performance (258 mAh ⋅ g−1 at the current density of 2 A ⋅ g−1) and was demonstrated as pseudocapacitive charge storage. As a consequence, the as‐prepared Co9S8@BNC possesses an exceptional electrochemical performance and could be utilized as a potential anode material candidate for SIBs.
Light‐Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum
Authors: Rustler Karin , Pockes Steffen , König Burkhard 
Published: January 2019

AbstractThe histamine H1 G protein‐coupled receptor (GPCR) plays an important role in allergy and inflammation. Existing drugs that address the H1 receptor differ in their chemical structure, pharmacology, and side effects. Light‐controllable spatial and temporal activity regulation of photochromic H1 ligands may contribute to a better mechanistic understanding and the development of improved correlations between ligand structure and pharmacologic effects. We report photochromic H1 receptor ligands, which were investigated in an organ‐pharmacological assay. Initially, five photochromic azobenzene derivatives of reported dual H1–H4 receptor antagonists were designed, synthesized, photochemically characterized, and organ‐pharmacologically tested on the isolated guinea pig ileum. Among them, one compound [trans‐19: (Z)‐1‐(4‐chlorophenyl)‐1‐(4‐methylpiperazin‐1‐yl)‐N‐(4‐((E)‐phenyldiazenyl)phenyl)methanimine] retained the antagonistic activity of its non‐photochromic lead, and trans–cis isomerization by irradiation induced a fourfold difference in the pharmacological response. Further structural optimization resulted in two bathochromically shifted derivatives of 19 [NO2‐substituted 35 {(Z)‐1‐(4‐chlorophenyl)‐1‐(4‐methylpiperazin‐1‐yl)‐N‐(4‐((E)‐(4‐nitrophenyl)diazenyl)phenyl)methanimine} and SO3−‐substituted 41 {4‐((E)‐(4‐(((Z)‐(4‐chlorophenyl)(4‐methylpiperazin‐1‐yl)methylene)amino)phenyl)diazenyl)benzenesulfonate}], which do not require the use of UV light for photoisomerization and which also have improved solubility and show reduced tissue impairment. The trans isomers of both compounds showed a remarkable increase in antagonistic activity relative to their lead trans‐19; furthermore, a 46‐fold difference in activity on the isolated guinea pig ileum was observed between trans‐ and cis‐35.
Population Pharmacokinetic Analysis of Daclatasvir, Asunaprevir, and Beclabuvir Combination in HCV‐Infected Subjects
Authors: Osawa Mayu , Ueno Takayo , Shiozaki Tomomi , Ishikawa Hiroki , Li Hanbin , Garimella Tushar 
Published: January 2019

AbstractA fixed‐dose combination of daclatasvir (pangenotypic NS5A inhibitor), asunaprevir (NS3/4A protease inhibitor), and beclabuvir (nonnucleoside NS5B inhibitor) was approved for hepatitis C virus treatment in Japan. The objectives of the analyses were to develop the daclatasvir, asunaprevir, and beclabuvir population pharmacokinetic models for the combination regimen. First, an original population pharmacokinetic model was developed using the data in non‐Japanese hepatitis C virus–infected subjects. The model was subsequently updated after a phase 3 study in Japanese hepatitis C virus–infected subjects was available. A total of 11,382, 11,300, and 10,728 pharmacokinetic records from 1,228 subjects were included for daclatasvir, asunaprevir, and beclabuvir in the updated model, respectively. Daclatasvir and beclabuvir pharmacokinetics (PK) were described by a 1‐compartment model with linear elimination and asunaprevir PK was described by 2‐compartment model with linear elimination. Cirrhosis, baseline, and time‐varying ALT were significant covariates on asunaprevir apparent oral clearance. Asian subjects had greater asunaprevir and beclabuvir exposures than white subjects. The effects of all covariates on daclatasvir PK were modest and not considered clinically significant. With the exception of race on asunaprevir and beclabuvir PK, no other parameters for daclatasvir, asunaprevir and beclabuvir population PK models were meaningfully impacted during the refinement with Japanese subjects.
Rapid and accurate energy models through calibration with IPMI and RAPL
Authors: Kavanagh Richard , Djemame Karim 
Published: January 2019

SummaryEnergy consumption in Cloud and High Performance Computing platforms is a significant issue and affects aspects such as the cost of energy and the cooling of the data center. Host level monitoring and prediction provides the groundwork for improving energy efficiency through the placement of workloads. Monitoring must be fast and efficient without unnecessary overhead, to enable scalability. This precludes the use of Watt meters attached per host, requiring alternative approaches such as integrated measurements and models. IPMI and RAPL are subject to error and partial measurement, which may be mitigated. Models allow for prediction and more responsive measures of power consumption, but require calibrating. The causes of calibration error are discussed, along with mitigation strategies, without overly complicating the underlying model. An outcome is a Watt meter emulator that provides hosts level power measurement along with estimated power consumption for a given workload, with an average error of 0.20W.
Edge/Defect‐Rich, Metallic, and Oxygen‐Heteroatom‐Doped WS2 Superstructure with Superior Electrocatalytic Performance for Green Solar Energy Conversion
Authors: Yin Jie , Wei Jiazhen , Guo Junxue , Shi Shaozhen , Chai Ning , Zhang Kaixuan , Xu Wenli , Yuan Cang , Liu Ting , Lin Weili , Zhang Qi , Zhou Huawei , Zhang Yingtian , Chen Baoli , Pu Xipeng , Li Wenzhi , Zhang Xianxi 
Published: January 2019

AbstractTwo‐dimensional tungsten sulfide is widely applied in electrocatalysis. However, WS2 possesses catalytic active sites located at the layer edge and an inert surface for catalysis. Therefore, increasing the exposure of active sites at the edge and effectively activating the inert sites on the surface is an important challenge. Here, an edge/defect‐rich and oxygen‐heteroatom‐doped WS2 (ED‐O‐WS2) superstructure was synthesized. The power‐conversion efficiency (PCE) of dye‐sensitized solar cells (DSCs) based on an ED‐O‐WS2 counter electrode reached 10.36 % (under 1 sun, AM 1.5, 100 mW cm−2) and 11.19 % (under 40 mW cm−2). These values are, to our knowledge, the highest reported efficiency for DSCs based on Pt‐free counter electrodes in I3−/I− electrolytes. Analysis of the micro/nano structure and the electrocatalytic mechanism indicate that ED‐O‐WS2 exhibits metallic properties in the electrolyte, and that abundant edges and defects as well as oxygen doping in ED‐O‐WS2 play an important role in improving the catalytic activity of WS2. Moreover, ED‐O‐WS2 displays better catalytic reversibility for I3−/I− electrolytes than Pt.