bluuebunny/crossref_metadata_2025_split huggingface dataset:
Good luck have fun: The need for video game pedagogy in teacher education
Authors: Richardson Tasha 
Published: November 2024

AbstractIn education, the shift to emergency remote teaching found teachers working to increase student engagement in the online environment while still relying on face‐to‐face pedagogical approaches in the absence of sufficient Professional Development opportunities (DeCoito & Estaiteyeh, 2022). In response to the growing interest in video games in education, this article reconsiders the data collected for a single case of primary/junior preservice teachers (PTs) enrolled in a science education methods classroom to answer (a) How can video games be used as a learning object in a teacher education program? (b) How does using a video game in a science education class impact PTs' intent and understanding of using video games in their future classroom? (c) How PTs can be supported to understand how video games can be used? Results found video games acted as significant springboards for learning as PTs worked together to make meaning of STEM and reflected—both during and after gameplay—on video game use with their future students. Additionally, exposure to digital game‐based learning increased both intent and confidence of using video games as deep learning objects for their future classrooms. Recommendations and implications are discussed regarding the introduction and integration of video games in a teacher education program.
Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients
Authors: Ansari E. , Minulina N. Carrillo , van Beers M. A. , van Es R. J. J. , Dieleman F. J. , Rosenberg A. J. W. P. , Janssen L. M. , Braunius W. W. , Van Cann E. M. , de Bree R. 
Published: November 2024

ABSTRACTBackgroundLow skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections.MethodsA retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated.ResultsLow SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95% CI 1.02–4.39, p = 0.029). Low SMM was associated with severe complications (Clavien–Dindo ≥ III) (OR 1.46; 95% CI 1.20–2.09, p = 0.02).ConclusionsLow SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.
Analysis of the Results of Tuberculosis Drug Resistance Surveillance in Yuexiu District, Guangzhou City, 2013–2022
Authors: Li Xueqiu , Liu Jianxiong 
Published: November 2024

ABSTRACTIntroductionThe objectives of the study are to understand the drug‐resistant situation and trend of tuberculosis patients in Yuexiu District, Guangzhou City, from 2013 to 2022, and to provide a scientific basis for the development of rational drug‐resistant tuberculosis prevention and control strategies in Guangzhou City.MethodsAll patients who were diagnosed with active tuberculosis in Guangzhou Chest Hospital from January 1, 2013 to December 31, 2022 were collected as study subjects, and a total of 5191 patients were enrolled in the study. Comprehensive data on the basic characteristics, diagnostic, and therapeutic information of the study subjects were collected. Sputum specimens were subjected to smear, isolation, and culture. Culture‐positive strains of bacteria were identified by bacterial groups. A total of 1659 strains of Mycobacterium tuberculosis (MTB) isolates were obtained. The drug susceptibility test was carried out using the proportionality method on the MTB isolates for nine types of antituberculosis medicines: isoniazid (INH), rifampicin (RFP), ethambutol (EMB), streptomycin (Sm), kanamycin (Km), ofloxacin (Ofx), capreomycin (Cm), propylthioisonicotinamide (Pto), and p‐aminosalicylic acid (PAS). A comparative analysis of the resistance patterns among the strains was conducted.ResultsA total of 1659 patients with MTB were cultured, revealing 438 drug‐resistant cases. Among these, 255 were monoresistant, 121 were polyresistant, and 62 were multidrug resistant. The overall resistance rate was 26.40% (438/1659), with mono‐resistance rate at 15.37% (255/1659), polyresistance rate at 7.29% (121/1659), and multidrug resistance rate at 3.74% (62/1659). In descending order, the resistance rates of MTB isolates to any of the nine antituberculosis drugs were Sm (12.24%, 203/1659), INH (9.22%, 153/1659), EMB (7.35%, 122/1659), RFP (6.99%, 116/1659), PAS (3.25%, 54/1659), Pto (3.13%, 52/1659), Ofx (2.71%, 45/1659), Cm (2.17%, 36/1659), and Km (2.17%, 36/1659). The differences in resistance rates were statistically significant (p < 0.01), with Sm exhibiting the highest resistance rate and Km the lowest.In the primary treatment group, 388 patients (25.55%) were drug resistant, while 50 patients (35.46%) in the retreatment group were drug resistant. Thirty‐nine patients (2.57%) in the primary treatment group were multidrug resistant, compared to 23 patients (16.31%) in the retreatment group. The resistance rate and multidrug resistance rate of isolates from retreatment patients were significantly higher than primary treatment patients (p < 0.05).ConclusionsThe problem of drug‐resistant tuberculosis transmission in Guangzhou requires attention, and drug‐resistant screening should be further increased to effectively control the source of infection.
Formoterol Reduces the Pro‐Inflammatory Phenotype by Enhancing the Activity of Glutaminase in Monocyte‐Derived Macrophages in the CVB3‐Induced Viral Myocarditis
Authors: Li Quan‐liang , Xie Hua‐bao , Guo Ying‐xin , Li Juan‐fen , Qian Jing , Wu Wei‐Feng 
Published: November 2024

ABSTRACTBackgroundViral myocarditis (VMC) plays a significant role in heart failure, and there is currently a shortage of available targeted treatments. Macrophage phenotype and function are closely associated with the beta‐2 adrenergic receptor (β2‐AR).MethodThis research employed a BALB/c mouse model of VMC generated using Coxsackievirus B3 (CVB3), and the β2‐AR agonist formoterol was administered as treatment. A bioinformatic analysis was conducted to identify the β2‐AR in CCR2+MHCIIhigh monocyte‐derived macrophages (MoMFs). Echocardiography and histopathological assessments were utilized to evaluate cardiac function and inflammation. The enzymatic activity of glutaminase (GLS) was quantified. Flow cytometry was employed to characterize the phenotype and function of the macrophages.ResultOur study revealed that formoterol treatment effectively mitigated cardiac inflammation and fibrosis, improved cardiac function, and prolonged survival compared to the VMC group. Formoterol reduced the infiltration of CCR2+MHCIIhigh MoMFs in the heart, inhibited M1 phenotypic expression and activity, and reduced the percentage of Ly6Chigh monocytes in circulation. Additionally, formoterol stimulated M2 phenotypic expression and activity and increased the percentage of Ly6Clow monocytes in circulation. Additionally, the combination of NICB3344, a C‐C motif chemokine receptor 2 inhibitor, with formoterol did not exhibit synergistic effects on reducing cardiac pathological scores or enhancing cardiac function. In vitro studies involving the use of lipopolysaccharide (LPS)‐induced bone marrow‐derived macrophages, revealed the ability of formoterol to suppress the M1 phenotype and functions induced by LPS while promoting the M2 phenotype and functions. Nevertheless, the observed effects were negated by the introduction of the GLS inhibitor BPTES.ConclusionFormoterol potentially serves as a significant metabolic regulator in the differentiation process of cardiac MoMFs, influencing this process by controlling GLS activity. Targeting β2‐AR exhibits potential as an effective approach for managing VMC. It is essential to acknowledge that these findings were derived under specific experimental conditions, with the current conclusions predominantly based on animal models. Future research is necessary to further investigate the feasibility of formoterol in clinical practice.
Deciphering the Ultrasound, CT, and MRI Imaging Features of a Post‐Vaginal Hysterectomy Gossypiboma Hiding as a Pelvic Mass—A Case Report
Authors: Gupta Isha , Nitharwal Pankaj , Gupta Ayush , Gupta Ankita , Mittal Mukesh 
Published: November 2024

ABSTRACTGossypiboma, or retained surgical sponge, is a rare post‐surgical complication with very few reported cases due to medico‐legal purposes. Diagnosis is very challenging due to the myriad of clinical presentations and imaging features. We present the case of a gossypiboma detected in a 72‐year‐old female with a recent history of vaginal hysterectomy. We describe the imaging findings in detail with the step‐wise use of X‐rays and ultrasound in raising suspicion and computed tomography (CT) and magnetic resonance imaging (MRI) to rule out other differentials and finally come to the diagnosis of gossypiboma, which was confirmed surgically.
Toxic Dye Degradation Employing Phoenix dactylifera Seed Extract for the Green Synthesis of Silver Nanoparticles: Characterization and Application
Authors: Maryam Areesha , Rabbani Saqib , Khan Athar Yaseen , Abid Hina , Zidan Ammar , Bahadur Ali , Qamar Muhammad Tariq , Iqbal Shahid , Mahmood Sajid , Farouk Abd‐ElAziem , Jafri Ibrahim 
Published: November 2024

ABSTRACTThis research highlights the facile green synthesis of silver nanoparticles (AgNPs) using Phoenix dactylifera seed extracts and its photocatalytic application for the degradation of toxic dyes. The AgNPs synthesis was confirmed by the appearance of its representative absorption peak at 416 nm in UV–visible absorption spectroscopy. Moreover, the reduction of silver ions to Ag was justified through Fourier transform infrared (FTIR) spectroscopy. X‐ray diffraction pattern revealed crystalline AgNPs structure with particle size ranging from 5 to 15 nm calculated using the Debye–Scherrer equation. The rectangular‐like structural morphology of synthesized AgNPs was observed in scanning electron micrographs. The as‐synthesized AgNPs demonstrated higher photocatalytic activity for the degradation of malachite green (MG) and congo red (CR) followed by methylene blue (MB), and crystal violet (CV) under UV irradiation. In addition, rate constant (k) and percentage degradation were also calculated. The present study presents a facile green synthesis pathway and its potentially successful manipulation in the reduction of toxic dyes under the illumination of UV‐light.
Endoscopic Full‐Thickness Plication for the Treatment of Gastroesophageal Reflux Disease: A Systematic Review and Meta‐Analysis of Randomized Sham Controlled Trials
Authors: Shahzil Muhammad , Chaudhary Ammad Javaid , Qureshi Ali Akram , Hasan Fariha , Faisal Muhammad Saad , Sohail Abdullah , Khaqan Muhammad Ali , Jamali Taher , Khan Muhammad Zarrar , Alsheik Eva , Zuchelli Tobias 
Published: November 2024

ABSTRACTIntroductionGastroesophageal reflux disease (GERD) affects approximately 20% of adults in the United States. Proton pump inhibitors are the first‐line treatment but are associated with long‐term side effects. Endoscopic full‐thickness plication (EFTP) is a minimally invasive alternative that improves the valvular mechanism of the gastroesophageal junction. This meta‐analysis compared EFTP to a sham procedure for the treatment of refractory GERD.Materials and MethodsThis meta‐analysis followed the Cochrane guidelines and PRISMA standards and was registered with PROSPERO (CRD42023485506). We searched MEDLINE, Embase, SCOPUS, and Cochrane Library through December 2023. Inclusion criteria targeted Randomized controlled trials comparing EFTP with sham procedures for GERD were included. Statistical analyses utilized RevMan with a random‐effects model, and the results were considered significant at p < 0.05.ResultsOf the 2144 screened studies, three RCTs with 272 patients with GERD were included: 136 patients underwent EFTP and 136 underwent sham procedures. Primary outcomes showed a significant reduction in PPI usage (RR 0.51; 95% CI 0.35–0.73; p < 0.01) and more than 50% improvement in GERD‐HRQL scores at 3 months (RR 15.81; 95% CI 1.40–178.71; p = 0.03). No significant difference was found in the DeMeester scores (MD: 12.57; 95% CI −35.12 to 9.98; p = 0.27). Secondary outcomes showed no significant difference in time with esophageal pH < 4, but a significant reduction in total reflux episodes.ConclusionsEFTP significantly reduced PPI usage, improved GERD‐HRQL scores, and decreased total reflux episodes compared with sham procedures, highlighting its potential as a minimally invasive treatment. Further research is needed to compare EFTP with other minimally invasive techniques to determine the most effective treatment option.
Tuning Into Learning: Enhancing Self‐Efficacy and Learning Behaviours Through Radio Education in Dedza, Malawi
Authors: Kim Eunsol , Jung Youyoung , Shin Jae Eun 
Published: November 2024

ABSTRACTIn the wake of COVID‐19, distance education has emerged as a critical tool in developing countries to overcome geographical barriers and enhance educational access. This study evaluates the impact of a radio education programme implemented by the Korea Food for the Hungry International in Dedza, Malawi. It specifically investigates the direct and indirect effects of radio education on students' learning behaviour and self‐efficacy, using survey data of 1654 students at 8 secondary schools in Dedza. Findings from multivariate regression analyses on two major outcome variables reveal that regular listening to radio education significantly enhances students' learning behaviour including class engagement and assignment completion, as well as students' self‐efficacy, especially in terms of resilience, positivity and self‐confidence. According to mediation analysis, self‐efficacy is examined to serve as a partial mediator in the relationship between radio education on student learning behaviour. The results underscore the potential of radio education in boosting academic achievements, by utilising the constructs of self‐efficacy to further enhance learning behaviour. The study contributes to the field through empirical and concrete evidence of radio education programmes and at the same time offers vital insights for interventions, using educational radio as a supplementary tool in similar contexts with vulnerability to regular education.
Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis
Authors: Wu Meng , Peng Xinyu , Xu Weidi , Zhang Hao , Fang Lian , Liu Xueqin , Miao Faming , Liu Quan , Mi Shijiang , Xiao Yuewen , Yu Xinglong , Tu Changchun , Ge Liangpeng , Liu Yan 
Published: November 2024

ABSTRACTRabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of costs, stability and safety. Our objective is to develop a novel and potential fully human monoclonal antibodies (mAbs) cocktail for the improvement of rabies PEP. The neutralizing fully human mAbs were screened by using fully humanized antibody mice (CAMouseHG). Then, two mAbs 26–12 G and 5–7 G were selected with potential neutralizing activity to RABV by using fluorescent antibody virus neutralization test (FAVN), which specifically bind to antigenic sites I and III of RABV‐glycoprotein (RABV‐G), the key amino acid residues were further identified in position 336, 337 of 5–7 G and 226, 227, 228 of 26–12 G by using cross‐linking and mass‐spectrometry. Both mAbs are highly conserved across 8 RABV strains (distributing in 3 lineages: Asian, Cosmopolitan and Arctic‐related) and 1 IRKV strain, and showed high neutralizing potential. Moreover, the in vivo experiment demonstrated that our cocktail can protect Kunming mice from a lethal RABV challenge. Collectively, we generate two noncompeting fully human mAbs (26–12 G, 5–7 G) and obtained cocktail CAM001 with their mixture. The high‐potency and broad‐spectrum neutralization of the cocktail supports its utility in human rabies PEP as an efficacious and affordable alternative to RIG products, particularly in endemic areas.
Iododerma with cryptococcus‐like changes
Authors: Subhadarshani S. , Flowers L. E. , Logan C. , Spicknall K. E. , Shaughnessy C. 
Published: November 2024

AbstractIododerma is a rare halogenoderma resulting from exposure to iodinated compounds. We present a case involving a 51‐year‐old Caucasian female with advanced renal disease who developed a hemorrhagic and papulonodular eruption following oral contrast exposure. Cryptococcoid bodies were noted on histopathological evaluation and raised suspicion for the diagnosis of iododerma, which was ultimately confirmed through serum and urine iodine studies. This case highlights a severe presentation of iododerma with important dermatopathology findings.
Partitions in real quadratic fields
Authors: Stern David , Zindulka Mikuláš 
Published: November 2024

AbstractWe study partitions of totally positive integers in real quadratic fields. We develop an algorithm for computing the number of partitions, prove a result about the parity of the partition function, and characterize the quadratic fields such that there exists an element with exactly 1–5, 7, and 11 partitions.
Pathogenicity of the LDLR c.97C>T (p.Gln33Ter) Mutation in Familial Hypercholesterolemia
Authors: Wang Kaihan , Hu Tingting , Tai Mengmeng , Shen Yan , Lin Shaoyi , Guo Yongjuan , Chen Xiaomin 
Published: November 2024

ABSTRACTBackgroundFamilial hypercholesterolemia (FH) is a hereditary disease caused mainly by mutations in the gene encoding the low‐density lipoprotein receptor (LDLR). This study aimed to confirm the pathogenicity of the LDLR c.97C>T (p.Gln33Ter) mutation through in vitro functional validation and determine whether this nonsense mutation induces nonsense‐mediated mRNA decay (NMD).MethodsThe proband and his family were included in accordance with Chinese Expert Consensus on FH screening. The disease‐causing mutations were fund using whole‐exome sequencing and were confirmed using bidirectional Sanger sequencing. The pathogenicity of the mutation was predicted using in silico analysis. The LDLR c.97C>T (p.Gln33Ter) mutation was generated using site‐directed mutagenesis and expressed in HEK293T cells lacking endogenous LDLR expression. The effects of this alteration on LDLR expression and LDL uptake were assessed using flow cytometry, quantitative polymerase chain analysis, western blotting, and confocal laser scanning microscopy.ResultsThe mutation that causes FH in this family was LDLR c.97C>T (p.Gln33Ter), and family members with this mutation exhibited elevated levels of low‐density lipoprotein cholesterol (LDL‐C). The cell experiment results showed that this mutation prevented the synthesis of LDLR protein and caused the cells to lose their LDL uptake ability.ConclusionLDLR c.97C>T (p.Gln33Ter) is a pathogenic FH mutation. However, this nonsense mutation did not induce NMD.
Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and in Vitro Anticancer Studies
Authors: Panduranga Padyala , Makam Parameshwar , Kumar Katari Naresh , Gundla Rambabu , Babu Jonnalagadda Sreekantha , Kumar Tripuramallu Bharat 
Published: November 2024

AbstractMolecular hybrids of diversely functionalized quinoline and sulfonamide have been designed. Multistep synthetic strategies have been used for the synthesis. The anti‐cancer properties have been evaluated against various cancer cell lines including HCT116, A549, U2OS, CCRF‐CEM, Jurkat, MOLT‐4, RAMOS, and K562. Non‐cancer cell lines MRC‐5 and BJ were also included for comparison. When examining the effects on A549, HCT116, and U2OS cells, all tested compounds exhibited limited potency with IC50 values exceeding 50 μM, indicating weak activity against these cell lines. Against the ITK high cells Viz. are Jurkat, CCRF‐CEM and MOLT‐4, 9 e, 9 p and 9 j found to the maximum potent compounds with IC50 values of 7.43±7.40 μM, 13.19±1.25 μM and 5.57±7.56 μM respectively. Similarly, in the BTK high cells screenings, 9 n and 9 e molecules with an IC50 value of 2.76±0.79 μM and 5.47±1.71 μM against RAMOS and K562 respectively are highly potent. Interestingly, all the molecules have exhibited IC50 value >50 μM against the non‐cancer cells (MRC‐5 and BJ), which indicates the promising non‐cytotoxic nature of the molecules.
Synergistic effects of extreme temperature and prebending on CF/PEKK composite flexural characteristics
Authors: Kumar Sanjay , Hwang Dong‐Wook , Li Xiaoqi , Shin Do‐Hoon , Kim Yun‐Hae 
Published: November 2024

AbstractThe mechanical properties of carbon‐fiber‐reinforced polymer composites are highly sensitive to temperature and preloading conditions. The behavior of carbon‐fiber/poly(etherketoneketone) (CF/PEKK) under various temperatures and prebending (PB) conditions is not fully understood. This study examines CF/PEKK's interlaminar shear strength, tensile, Mode II, and bending properties at room temperature (RT, 25°C), low temperature (LT, −60°C), and extreme cryogenic temperature (ECT, −196°C). The combined effects of temperature and PB at 30%, 50%, and 70% of ultimate displacement for 24 and 72 h were analyzed. Results indicate that decreasing temperature increases shear strength, improves tensile properties, and reduces fracture toughness. Bending tests show that strain, yield strength, and yield strain rise significantly from RT to ECT, while the modulus remains similar, but the postyield modulus decreases. Higher PB intensity reduces strength, moduli, and strain. Under combined PB and LTs, CF/PEKK shows a coupled mechanism with PB‐induced microcracks mitigated by low‐temperature failure mechanism. Strength increased by ~20% from RT to ECT, and 30%‐prebent samples retained over 80% residual flexural strength even at LT and ECT. These findings highlight CF/PEKK's excellent bending resistance at extreme temperatures, emphasizing its potential for aerospace applications.Highlights
Temperature significantly impacts CF/PEKK composites' mechanical properties.
Decreasing temperature increases shear strength and tensile properties.
PB‐induced microcracks and low temperatures influence flexural properties.
CF/PEKK composites show excellent bending resistance in extreme conditions.
High residual strength persists at low temperatures and after prebending.