bluuebunny/crossref_metadata_2025_split huggingface dataset:
Once-Weekly Efpeglenatide Dose-Range Effects on Glycemic Control and Body Weight in Patients With Type 2 Diabetes on Metformin or Drug Naive, Referenced to Liraglutide
Authors: Rosenstock Julio , Sorli Christopher H. , Trautmann Michael E. , Morales Cristóbal , Wendisch Ulrich , Dailey George , Hompesch Marcus , Choi In Young , Kang Jahoon , Stewart John , Yoon Kun-Ho 
Published: July 2019

OBJECTIVE
To explore the efficacy, safety, and tolerability of once-weekly efpeglenatide, a long-acting glucagon-like peptide 1 receptor agonist (GLP-1 RA), in early type 2 diabetes (T2D) (drug naive or on metformin monotherapy).

RESEARCH DESIGN AND METHODS
EXCEED 203 was a 12-week, randomized, placebo-controlled, double-blind, parallel-group, dose-ranging study of efpeglenatide once weekly referenced to open-label liraglutide 1.8 mg (exploratory analysis). Participants, ∼90% on metformin monotherapy, were randomized to one of five efpeglenatide doses (0.3, 1, 2, 3, or 4 mg q.w.; n = 181), placebo (n = 37), or liraglutide (≤1.8 mg daily; n = 36). The primary efficacy end point was change in HbA1c from baseline to week 13.

RESULTS
From a baseline HbA1c of 7.7–8.0% (61.0–63.9 mmol/mol), all efpeglenatide doses ≥1 mg significantly reduced HbA1c versus placebo (placebo-adjusted least squares [LS] mean changes 0.6–1.2%, P &lt; 0.05 for all) to a final HbA1c of 6.3–6.8% (45.4–50.6 mmol/mol); masked efpeglenatide 4 mg was noninferior to open-label liraglutide. Greater proportions treated with efpeglenatide ≥1 mg than placebo achieved HbA1c &lt;7% (61–72% vs. 24%, P &lt; 0.05 for all), and greater reductions in body weight were observed with efpeglenatide 3 and 4 mg versus placebo (placebo-adjusted LS mean differences −1.4 and −2.0 kg, respectively, P &lt; 0.05 for both). Rates of nausea and vomiting were consistent with other GLP-1 RAs and rapidly subsided after the initial 2 weeks. No neutralizing antibodies were detected with efpeglenatide.

CONCLUSIONS
Efpeglenatide once weekly led to significant reductions in HbA1c and weight, with a safety profile consistent with the GLP-1 RA class in patients with early T2D mostly on metformin monotherapy.
„Dann leg’ ich meinen Hobel hin...”. Nachrufe und Todesanzeigen mit Tätigkeitsbezug aus interkultureller Sicht
Authors: Mihail Cristina 
Published: July 2019

Abstract
Beyond the communicative function of death notices, to informe about a death case, one will be repeatedly surprised by auxiliary functions of this category of private notices. The following article analizes from an intercultural perspective the representation of the (professional) identity in obituaries and death notices pertaining to a Romanian and a German corpus – the achievements attained to in the job environment and – in case of a blurred or merely outlined professional identity – on interests outside of one’s job, which were cherished by the deceased to the effect of shaping and defining him.
Silent and Surprising Pathology: Appendix Tumors-Incidental Finding of a Rare Mucinous Appendiceal Adenocarcinoma
Authors: Mihaela-Cristina Ailenei , Roxana Călin , Mădălina Prună , Cătălin Mitru , Mariana Jinga , Florentina Ioniţă-Radu , Cristina Sandu , Săndica Bucurică 
Published: July 2019

Abstract
Appendiceal epithelial tumors are a rare finding in comparison with the incidence of colorectal cancer that is approximately 100-fold higher. As appendiceal neoplasms and colorectal cancer have a different clinical and tumoral behavior, these tumors are classified separately in the various tumor classifications. Most appendiceal neoplasms are found during surgery or postoperatively in appendectomy specimens. Given the possibility of neoplastic peritoneal dissemination, the lack of symptoms is a serious problem.
However, the percentage of appendiceal tumors that is incidentally discovered by imaging is increasing over time. Primary adenocarcinoma of the appendix is exceedingly rare and frequently has an extremely poor prognosis because it is diagnosed in advanced stages.
Effect of Chilling and Accumulative Photo-Thermal Units on Flowering of Strawberry (Fragaria × ananassa Duch.)
Authors: Al-Madhagi Isam A.H. , Al-Munibary Mahassen , Al-Doubibi Manssur 
Published: July 2019

Abstract
The influence of chilling period hours and accumulative photo-thermal unit at different base temperatures, 10, 11, 13, 15, and 18 °C, on the flowering of strawberry was examined in Sana’a University-Yemen during two seasons: 2006 and 2007. The randomized complete block design (RCBD) field experiment was designed with 5 chilling hours (CHs) periods (0, 360, 750, 1080, and 1440 CHs under 2 ± 1 °C), with four replicates each. Accumulative photo-thermal unit (PTU) was calculated for every treatment at different base temperatures for two stages: (i) from planting date to the flower opening (THA) and (ii) from planting date until the end of 2 months (THB). The results revealed that the plants treated with 1080 h of chilling produced flowers with about 55.12% and 61.97% earlier when compared with control (without chilling) in both the seasons, respectively. Stepwise multiple regression analysis showed that both CHs and the accumulative PTU THA13 (in the first season) and CH plus THA10 (in the second season) have significant effect on days until flower opening, in which the majority effect was related to the chilling period. The effect of chilling period and accumulative PTU at 18 °C (THB18) had s significant influence (p < 0.05) on the number of early flower per plant, with about r2 = 0.250 and r2 = 0.536 in both the seasons, respectively, and r2 = 0.531 and r2 =0.740 for the total effect of both CH and THB18, respectively. However, the exposure of plants to the long period of chilling (1080 and 1440 h) led the plants to produce runners and break up the flowering stage after 9 and 11 weeks in both the seasons, respectively. Meanwhile, plants that received 360-h chilling produced significantly highest (p < 0.05) total number of flowers (24.83 per plant), with about 71.2% higher than that produced by control plants. Moreover, in the second season, plants treated with 750-h chilling produced the significantly higher total number of flowers per plant, with about 50.3% higher than that of the control. Meanwhile, the 360-h and 750-h chilling periods have similar effect on the number of flowers per plant in the second season. The result showed that the starch level in the crown significantly positively correlated with the days to flower opening (r2 = 0.415, p = 0.05) and negatively correlated with the number of early flower (r2 = 0.587, p = 0.01). The data from this study might be used for the management of strawberry production.
Growth, Evapotranspiration and Mineral Content of Gerbera Under Combined Salinity and Excess Boron
Authors: Gómez Bellot María José , Carmassi Giulia , Bartalucci Manuele , Sánchez-Blanco María Jesús , Pardossi Alberto 
Published: July 2019

Abstract
Gerbera is a very important plant widely grown for cut flowers. To check the influence of salinity and boron excess in nutrient solution, nine treatments as factorial combination of three sodium chloride (NaCl) (1, 15 and 30 mM) and three boron (B) (0.1, 1 and 2 mM) concentrations in the nutrient solution were applied during the gerbera cultivation. The effects of experimental treatments on gerbera growth, flowering and the interaction in morphological and nutritional aspects were tested. The formation of leaves, stems and flowers, flower dry mass and evapotranspiration (ET) were more negatively affected when plants were irrigated with 2 mM B than with 0.1 mM B concentration. High levels of boron (1 and 2 Mm) in nutrient solution resulted in leaf chlorosis and necrosis. The severity of leaf burn was correlated with leaf B content. Salinity acted as a protector against boron content in leaves and flowers at 1 Mm B. However, at the 2 Mm B in nutrient solution, leaf B accumulation was not reduced by the presence of NaCl but also increased with the increased levels of salinity. The external levels of boron used in this study, which were found to be the highest in the literature, and the high sensitivity of gerbera to boron, suggested that boron acted as the dominant factor. Lower external boron concentrations would be needed to establish to what extent salinity would be able to mitigate the negative effects of boron.
Revista VIS, volume 12, número 1, ano 2013 - Editor Responsável: MARCUS MOTA
Authors: Oliveira Emerson Dionisio Gomes de 
Published: July 2019

Considerações acerca das pesquisas e influências de Tedeusz Kantor no BrasilWagner Francisco Araujo Cintra Actors, Screens and the Scene as operation: Gordon Craig and the Contemporary TheatreLuiz Fernando Ramos Au croisement des mises en scène filmique et thpeâtraleRoberta K. Matsumoto Retratos de Augustine : de paciente histérica à heroína feministaMaria Brígida de Miranda The Materialization of the Work of Art: Action and PoliticsAntonio Delgado Arthur Azevedo: O Teatro de Revista entre a Vida e a ArteRobson Corrêa de Camargo Touradas, mito e metáforas na criação cênicaMárcia Duarte Pinto Coreografia e TranscoreografiaCínthia Nepomuceno Eugene scribe and the French Grand OperaPaulo Ricardo Berton Tennesse Williams and the Creative Frisson of CensorshipS.E.Gontarski Catarse, rasa, flor: contextualizando a produção de emoções a partir da comparação de tradições perfomativo-musicaisMarcus Mota Utilização de conceitos poéticos e dramáticos para investigação em canção de câmara: Quatro Líricas (1938) de Francisco Mignone com poesia de Manuel BandeiraGisele Pires Mota Discurso de recebimento do título de professor emérito pela Universidade de BrasíliaHugo Rodas Dissertações e Teses defendidas no PPG-Arte no período 1º/2013 Normas para colaboradores
VARIABILITY AND CORRELATION OF QUANTITATIVE CHARACTERS OF THE SUDAN GRASS
Authors: Alabushev А. V. , Kovtunova N. А. , Kovtunov V. V. , Romanyukin А. Е. , Shishova Е. А. 
Published: July 2019

The correlation between the traits allows making an indirect selection, while the selection according to one trait results in the selection of another indicator. The purpose of the work is to estimate the variability of quantitative traits of Sudan grass and the correlations between them, to identify marker traits of high productivity and quality of green mass. There have been presented the study results of 115 collection samples of Sudan grass with various environmental and geographical origin of the Rostov region made in 2014-2018. There was a great variability (V=29.7-50.0%) in tillering, leaf square, green mass yield, stem diameter, plant height among the studied varieties. The percentage of fiber and nitrogen-free extractive substances in the green mass of the studied Sudanese grass samples were characterized with high stability (V = 4.9-5.0%). The analysis has identified a strong correlation between green mass productivity and leaf length (r=0.59±0.01), leaf width (r=0.57±0.02), leaf square (r=0.54±0.03), plant height (r=0.48±0.06), length of ‘vegetation-ear formation’ period (r=0.48±0.004) and number of leaves (r=0.42±0.03). There has been identified a group of samples ‘Boldinsky’, ‘Fioros’, ‘К-176’, ‘К-205, ‘К-272’ with 35-55 t/ha green mass productivity and with 20.5-24.5% dry matter in green mass. The conducted analysis has shown that dry matter percentage greatly correlates with plant height (r=0.30±0.001), vegetation period (r=0.34±0.004) and number of leaves (r=0.26±0.006). The markers of high productivity and quality of green mass are length of a vegetation period and number of leaves (their increase results in the growth of green mass yields), dry matter percentage in green mass and protein decrease in it.
A Comparative Study of Intravenous Nitroglycerin With or Without Intravenous Lignocaine for Attenuation of Stress Responses to Endotracheal Intubation
Authors: Regmi Nabin Kumar , Singh Grisuna 
Published: July 2019

Background: Laryngoscopy and tracheal intubation lead to stress response which is characterized by transient rise in blood pressure and heart rate. This response is tolerated well in normal individuals but can lead to significant morbidity and mortality in patients with cardiovascular and cerebrovascular diseases. Search for the better drugs to suppress these responses is going on through decades.
Aim of Study: To compare the effects of IV nitroglycerin alone and in combination with IV lignocaine, on attenuation of stress response to end tracheal intubation.
Material and Methods: This is a randomized, double blind study conducted in 60patients admitted for operation at NGMCTH, between June 2018 to November 2018. Patients were of 16- 60 years age groups and belonging to ASA group I and II. Patients were divided into two groups: Group I IV Nitroglycerin 500 mcg+ NS 3 ml. (n=30) and Group IIIV Nitroglycerin 500 mcg+ IV Lignocaine 63 mg (n=30). Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) and Heart rate (HR) were measured and Rate Pressure Product (RPP) calculated.
Results: Baseline values were comparable in both groups. Post Intubation, there was significant decrease in SBP at 0,1,3 and 5 minutes while DBP and MAP significantly decreased at 1, 3 and 5 minutes, in both groups. Significant tachycardia was noted in both groups at 0,1and 3 minutes, and RPP remained unchanged in both groups.
Conclusion: Nitroglycerin significantly decreases blood pressure, prevents rise in RPP but does not attenuate heart rate after end tracheal intubation. There is no benefit of adding IV lignocaine to IV nitroglycerin for attenuation of stress response to end tracheal intubation.
LATIHAN OTOT DASAR PANGGUL DAN KOMUNIKASI SEKSUAL PADA IBU PASCASALIN
Authors: Pramanik Novita Dewi 
Published: July 2019

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi Latihan Otot Dasar Panggul (LODP) dan komunikasi seksual terhadap peningkatan kualitas hubungan seksual ibu pascasalin. Responden penelitian adalah wanita yang berada dalam rentang 2-3 bulan pascasalin. Desain penelitian menggunakan metode campuran concurrent embedded. Pada tahap kuantitatif menggunakan eksperimen semu pre-posttest control group design, sedangkan tahap kualitatif menggunakan pendekatan fenomenologi dengan teknik wawancara mendalam yang berusaha menggali informasi mengenai pengaruh LODP dan komunikasi seksual terhadap kepuasan seksual ibu pascasalin. Kuesioner Female Sexual Function Index (FSFI) digunakan untuk mengukur 6 dimensi seksual yang menggambarkan kualitas sebuah hubungan seksual, yaitu hasrat seksual, gairah seksual, lubrikasi, orgasme, kepuasan seksual dan nyeri saat berhubungan seksual. Hasil analisis secara kuantitatif dan kualitatif menunjukkan adanya peningkatan kualitas hubungan seksual pada ibu pascasalin pada kelompok intervensi dan kontrol (p<0.05). Hasil wawancara mendalam mempertegas bahwa unsur psikologis memegang peranan penting dalam membantu meningkatkan kualitas hubungan seksual ibu pascasalin, yang terfasilitasi melalui intervensi komunikasi seksual.
Kata kunci: Hubungan seksual ibu pascasalin, komunikasi seksual, latihan otot dasar panggul
Occipital and external acoustic meatus to axis angle: a useful predictor of oropharyngeal space in rheumatoid arthritis patients with atlantoaxial subluxation
Authors: Morizane Kazuaki , Takemoto Mitsuru , Neo Masashi , Fujibayashi Shunsuke , Otsuki Bungo , Tanida Shimei , Shimizu Takayoshi , Ito Hiromu , Matsuda Shuichi 
Published: July 2019

OBJECTIVEDyspnea and/or dysphagia is a life-threatening complication after occipitocervical fusion. The occiput-C2 angle (O-C2a) is useful for preventing dyspnea and/or dysphagia because O-C2a affects the oropharyngeal space. However, O-C2a is unreliable in atlantoaxial subluxation (AAS) because it does not reflect the translational motion of the cranium to C2, another factor affecting oropharyngeal area in patients with rheumatoid arthritis (RA) who have reducible AAS. The authors previously proposed the occipital and external acoustic meatus to axis angle (O-EAa; i.e., the angle made by McGregor’s line and a line joining the external auditory canal and the middle point of the endplate of the axis [EA line]) as a novel, useful, and powerful predictor of the anterior-posterior narrowest oropharyngeal airway space (nPAS) distance in healthy subjects. The aim of the present study was to elucidate the validity of O-EAa as an indicator of oropharyngeal airway space in RA patients with AAS.METHODSThe authors investigated 64 patients with RA. The authors collected lateral cervical radiographs at neutral position, flexion, extension, protrusion, and retraction and measured the O-C2a, C2-C6, O-EAa, anterior atlantodental interval (AADI), and nPAS. Patients were classified into 2 groups according to the presence of AAS and its mobility: group N, patients without AAS; and group R, patients with reducible AAS during dynamic cervical movement.RESULTSGroup N had a significantly lower AADI and O-EAa than group R in all but the extension position. The O-EAa was a better predictor for nPAS than O-C2a according to the mixed-effects models in both groups (marginal R2: 0.510 and 0.575 for the O-C2a and O-EAa models in group N, and 0.250 and 0.390 for the same models, respectively, in group R).CONCLUSIONSO-EAa was superior to O-C2a in predicting nPAS, especially in the case of AAS, because it affects both O-C2a and cranial translational motion. O-EAa would be a useful parameter for surgeons performing occipitocervical fusion in patients with AAS.
Multilingualism and Dementia Risk: Longitudinal Analysis of the Nun Study
Authors: Hack Erica E. , Dubin Joel A. , Fernandes Myra A. , Costa Sanduni M. , Tyas Suzanne L. 
Published: July 2019

Background: Multilingualism is associated with enhanced executive function and may thus prevent cognitive decline and reduce the risk of dementia. Objective: To determine whether multilingualism is associated with delayed onset or reduced risk of dementia. Methods: Dementia was diagnosed in the Nun Study, a longitudinal study of religious sisters aged 75+ years. Multilingualism was self-reported. Dementia likelihood was determined in 325 participants using discrete-time survival analysis; sensitivity analyses ( n = 106) incorporated additional linguistic measures (idea density and grammatical complexity). Results: Multilingualism did not delay the onset of dementia. However, participants speaking four or more languages (but not two or three) were significantly less likely to develop dementia than monolinguals (OR = 0.13; 95% CI = 0.01, 0.65, adjusted for age, apolipoprotein E, and transition period). This significant protective effect of speaking four or more languages weakened (OR = 0.53; 95% CI = 0.06, 4.91) in the presence of idea density in models adjusted for education and apolipoprotein E. Conclusion: Linguistic ability broadly was a significant predictor of dementia, although it was written linguistic ability (specifically idea density) rather than multilingualism that was the strongest predictor. The impact of language on dementia may extend beyond number of languages spoken to encompass other indicators of linguistic ability. Further research to identify the characteristics of multilingualism most salient for risk of dementia could clarify the value, target audience, and design of interventions to promote multilingualism and other linguistic training as a strategy to reduce the risk of dementia and its individual and societal impacts.
Balance among calcium, magnesium and potassium levels affecting Asian Soybean Rust severity
Authors: Gaspar Guilherme Garcia , Takahashi Hideaki Wilson , Canteri Marcelo Giovanetti , Almeida José Carlos Vieira de , Fioretto Roberto Antunes , Andrade Braitner Luiz Giorgines , Fantin Lucas Henrique 
Published: July 2019

This work aimed to analyze the effect of the variation of the proportions of calcium in relation to the contentes of magnesium and potassium in the cationic capacity of change (CCC) of the soil, seeking to propitiate the appropriate balance of bases, so that the soybean plants presented good nutritional state and had conditions of resisting to the attack of Phakopsora pachyrhizi Syd. & P. Syd. The experiment was driven in randomized blocks with eight replications and the treatments consisted of doses of Ca:Mg:K in relation to CCC of the soil being:1) without correction of the bases (original soil with 3,8%:6,6%:2,4%); 2) 35:15:5; 3) 45:15:5; 4) 55:15:5; 5) 65:15:5; 6) 75:15:5. The soybean cultivar used in the experiment was BRS 184, sowed in mud vases containing dystrophic Red Latosol (Oxisol) as substrate. The inoculation was realized in the fenologic stadium V4. The disease severity was determined through visual notes considering the percentage foliate area with visible symptoms of the disease, being calculated the Area Under Disease Progress Curve (AUDPC). The data were submitted to the variance analysis (p<0.05) and fitting to regression models. The balance among the nutrientes was analyzed being calculated the index DRIS. The contents of nutrients, the matter dry indexes (MDI) and nutritional balance index (NBI) were inserted in the program ChecarDris for obtaining of the index DRIS. The results appeared that the percentages of 55% of calcium, 15% of magnesium and 5% of potassium, increase larger nutritional balance in the soybean providing to smallest area under disease progress curve (AUDPC), reduction in the severity of the rust (%), besides increase the largest productivity.
Identifikasi Warna Kerabang Telur Ayam Ras Menggunakan Jaringan Syaraf Tiruan
Authors: Darmawan Iman Budi , Maimunah Maimunah , Whidiasih Retno Nugroho 
Published: July 2019

Abstract

Eggs are a food source of animal protein that is cheap and easy to get by the people of Indonesia. Eggs have a complete nutritional content ranging from protein, fat, vitamins and minerals. This study aims to identify the color of broiler eggshell to dark brown, brown, and light brown, it shows that dark brown chicken eggs are better than brown and light brown. The estimator variable used is RGB (red, green, blue), extraction from the egg image taken using a 20 megapixel DSLR camera. The data used is 90 egg images. Training data amounted to 72 data and testing data totaling 18 data. Color identification of eggshells using backpropagation artificial neural network with the penduga red, green, blue parameters of the egg image, the most optimal weight obtained at 59th epoch at 03 seconds with neurons 2 in the hidden layer, with an MSE value of 0.160 and a success rate of 72%.

Keywords: backpropagation, identification, race chicken eggs, RGB, shell color.

Abstrak

Telur merupakan makanan sumber protein hewani yang murah dan mudah untuk didapatkan oleh masyarakat Indonesia. Telur memiliki kandungan gizi yang lengkap mulai dari protein, lemak, vitamin, dan mineral. Penelitian ini bertujuan untuk mengidentifikasi warna kerabang telur ayam ras menjadi warna coklat tua, coklat, dan coklat muda, hal tersebut menunjukkan bahwa telur ayam dengan warna coklat tua lebih baik dibandingkan dengan warna coklat dan coklat muda. Variabel penduga yang digunakan adalah rgb (red, green, blue), ekstraksi dari citra telur yang diambil menggunakan kamera DSLR 20 megapiksel. Data yang digunakan berjumlah 90 citra telur. Data training berjumlah 72 data dan data testing berjumlah 18 data. Identifikasi warna kerabang telur menggunakan jaringan syaraf tiruan backpropagation dengan parameter penduga red, green, blue dari citra telur, bobot yang paling optimal didapatkan pada epoch ke 59 di detik ke 03 dengan neuron 2 pada lapisan tersembunyi, dengan nilai MSE sebesar 0.160 dan tingkat keberhasilan sebesar 72%.

Kata kunci: backpropagation, identifikasi, RGB, telur ayam ras, warna kerabang.