bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arabidopsis Actin-Binding Protein WLIM2A Links PAMP-Triggered Immunity and Cytoskeleton Organization
Authors: Manickam Prabhu , Abulfaraj Aala A. , Alhoraibi Hanna M. , Veluchamy Alaguraj , Almeida-Trapp Marilia , Hirt Heribert , Rayapuram Naganand 
Published: October 2024

Arabidopsis LIM proteins are named after the initials of three proteins Lin-11, Isl-1, and MEC-3, which belong to a class of transcription factors that play an important role in the developmental regulation of eukaryotes and are also involved in a variety of life processes, including gene transcription, the construction of the cytoskeleton, signal transduction, and metabolic regulation. Plant LIM proteins have been shown to regulate actin bundling in different cells, but their role in immunity remains elusive. Mitogen-activated protein kinases (MAPKs) are a family of conserved serine/threonine protein kinases that link upstream receptors to their downstream targets. Pathogens produce pathogen-associated molecular patterns (PAMPs) that trigger the activation of MAPK cascades in plants. Recently, we conducted a large-scale phosphoproteomic analysis of PAMP-induced Arabidopsis plants to identify putative MAPK targets. One of the identified phospho-proteins was WLIM2A, an Arabidopsis LIM protein. In this study, we investigated the role of WLIM2A in plant immunity. We employed a reverse-genetics approach and generated wlim2a knockout lines using CRISPR-Cas9 technology. We also generated complementation and phosphosite-mutated WLIM2A expression lines in the wlim2a background. The wlim2a lines were compromised in their response to Pseudomonas syringae Pst DC3000 but showed enhanced resistance to the necrotrophic fungus Botrytis cinereae. Transcriptome analyses of wlim2a mutants revealed the deregulation of immune hormone biosynthesis and signaling of salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) pathways. The wlim2a mutants also exhibited altered stomatal phenotypes. Analysis of plants expressing WLIM2A variants of the phospho-dead or phospho-mimicking MAPK phosphorylation site showed opposing stomatal behavior and resistance phenotypes in response to Pst DC3000 infection, proving that phosphorylation of WLIM2A plays a crucial role in plant immunity. Overall, these data demonstrate that phosphorylation of WLIM2A by MAPKs regulates Arabidopsis responses to plant pathogens.
ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных экспериментальных исследований в здравоохранении. Приведены практические примеры расчета размера выборки и статистического сравнения наблюдаемых групп с помощью онлайн-калькуляторов. Авторы представляют практические примеры использования экспериментальных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения об экспериментальных исследованиях, и не заменяет прочтения специализированной литературы по клинической эпидемиологии.
In this paper we present basic principles of planning and carrying out experimental studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and group comparison using online calculators. Examples of experimental studies from international peer-reviewed literature are also presented. This article provides general introduction to experimental studies and does not substitute specialized literature in clinical epidemiology.
Осы жұмыста денсаулық сақтаудағы көлденең эксперименталды зерттеулердіжоспарлау, өткізу және статистикалық өңдеудің негізгі принциптері көрсетілген. Epi Info эпидемиологиялық мәліметтерді өңдеу үшін онлайн-калькуляторлар мен пакет көмегімен қауіп факторлары арасындағы байланысты таңдау және бағалау мөлшері есебінің практикалық мысалдары келтірілген. Авторлар әдебиеттегі көлденең эксперименталды зерттеулерді пайдаланудың практикалық мысалдарын, сол сияқты осы зерттеу түрлері қасиеттері мен жетіспеушіліктерін келтіреді. Осы мақала көлденең эксперименталды зерттеулер туралы жалпы мәліметтер беруге бейімделген, және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқуды ауыстырмайды.
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ЛИМФОМЫ ХОДЖКИНА ВИЛОЧКОВОЙ ЖЕЛЕЗЫ, А ТАКЖЕ ПОЗДНЕЕ ПОСЛЕОПЕРАЦИОННОЕ ОСЛОЖНЕНИЕ – РЕЛАКСАЦИЯ ОБОИХ КУПОЛОВ ДИАФРАГМЫ. КЛИНИЧЕСКИЙ ПРИМЕР
Authors: С.Д. Фокеев , С.Ю. Капитулин , Е.С. Казанцева , Э.К. Капитулина , М.К. Сыздыкбаев 
Published: October 2024

Резюме Представлены результаты комплексного лечения вилочковой железы, пораженной лимфомойХоджкина. На первом этапе выполнена радикальная операция - удаление массивного опухолевого поражения средостения, с последующей химиотерапией. Безрецидивное (14 летнее) наблюдение за больной, выявило позднее послеоперационное осложнение – релаксация обоих куполов диафрагмы, которое потребовало хирургической коррекции.
This article presents the results of complex treatment of Hodgkin lymphoma involving the thymus gland. At the first stage, a radical operation was performed- removal of a massive mediastinal tumor, followed by chemotherapy. Recurrence-free (14-year) examination of the patient revealed a late postoperative complication-relaxation of both diaphragm domes, which required surgical correction.
Ходжкин лимфомасымен закымдалған айырша бездің кешенді емінің нәтижелері көрсетілген. Бірінші кезеңде массиивті ісікпен зақымдалған көкірек қуысына операция жасалган, кейіннен химиотерапия. Рецидивсіз 14 жыл, наукасты бакылау операциядан кейінгі кеш асқынулар - диафрагманың екң доғасының релаксациясы, өз кезегінде хирургиялык араласуды кажет етеді.
КЛИНИЧЕСКИЙ СЛУЧАЙ САРКОИДОЗА ЛЕГКИХ У ПАЦИЕНТКИ С ОНКОПАТОЛОГИЕЙ
Authors: М.А. Есенгельдинова , Р.А. Бакенова , Т.З. Сейсембеков 
Published: October 2024

Плановое проведение флюорографического обследования органов грудной клетки явилось отправным пунктом диагностического процесса. Сложность данного клинического случая обусловлена тем, что, результаты ПЭТ, совмещенной с КТ легких в сочетании с анамнестическими данными, интерпретировали как раковой процесс в легких с метастазированием. Однако отсутствие клинической картины онкологического процесса, «спокойные» лабораторные показатели инициировали углубленное обследование с морфологической верификацией диагноза (методом получения материала была трансбронхиальная биопсия легких и внутригрудных лимфатических узлов), а назначенная терапия системными глюкокортикостероидами улучшило состояние пациентки и предшествующих рентгенологических изменений. Данный случай демонстрирует необходимость индивидуального (персонифицированного) подхода в диагностике и лечении саркоидоза.
The planned fluorographic examination of the chest organs was starting point of the diagnostic process. The complexity of this clinical case is due to the fact that the results of PET combined with CT of the lungs in combination with anamnestic data were interpreted as a cancer process in the lungs with metastasis. However, the absence of a clinical picture of the oncological process, such as a “с alm” laboratory parameter initiated an in-depth examination with morphological verification of the diagnosis (the method of obtaining the material was transbronchial biopsy of the lungs and intrathoracic lymph nodes). In addition, the prescribed therapy with systemic glucocorticoids improved the patient's condition and previous radiological changes. This case demonstrates the significance of individual (personalized) approach in the diagnosis and treatment of sarcoidosis.
Кеуде мүшелерін жоспарлы флюорографиялық тексерудиагностикалық процестің бастапқы нүктесі болды. Бұл клиникалық жағдайдың күрделілігі ПЭТ нәтижелерінің өкпенің КТ-мен анамнестикалық мәліметтермен біріктірілген нәтижелері метастазбен өкпеде қатерлі ісік процесі ретінде түсіндірілуіне байланысты. Алайда, онкологиялық процестің клиникалық көрінісінің болмауы, зертханалық «тыныштық» параметрлері диагнозды морфологиялық тексерумен терең зерттеуді бастады (материал алу әдісі өкпенің трансбронхиалды биопсиясы және кеуде ішілік лимфа түйіндері) және жүйелі глюкокортикостероидтармен тағайындалған терапия науқастың жағдайын және бұрынғырентгенологиялық өзгерістерді жақсартты. Бұл жағдай саркоидозды диагностикалау мен емдеудіжеке (дербестендірілген) тәсілдің қажеттілігін көрсетеді.
КЛИНИЧЕСКИЙ СЛУЧАЙ: СИМПТОМАТИКА И ЭФФЕКТИВНОСТЬ ЛЕЧЕНИЯ КОРОНАВИРУСНОЙ ИНФЕКЦИИ НА ФОНЕ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК
Authors: Г.К. Капанова , А.Ш. Каскабаева , Р.И. Алибекова , А.С. Ботабаева , Д.К. Муздубаев 
Published: October 2024

В данной статье представлен клинический случай особенностей течения и лечения новой коронавирусной инфекции на фоне хронической почечной недостаточности смешанного происхождения, развившейся вследствие нескольких дегенеративных заболеваний, наиболее часто встречающихся в современном мире. Проведенный анализ демонстрируемой истории болезни свидетельствует о негативном влиянии хронической болезни почек на характер течения Ковид-инфекции. Кроме того, довольно отчетливо прослеживается существенное влияние на прогноз при лечении острого вирусного процесса стадии хронической почечной недостаточности. Именно этот фактор определяет степень адекватного ответа на применяемое комплексное лечение новой коронавирусной инфекции, включающее использование этиотропных, патогенетических, симптоматических лекарственных средств. Современные схемы лечения тяжелых форм новой коронавирусной инфекции позволяют улучшить прогноз при этом заболевании у лиц с хроническими заболеваниями внутренних органов.
This article presents a clinical case of the features of the course and treatment of a new coronavirus infection against the background of the chronic renal failure of mixed origin, which developed as a result of several degenerative diseases, that are most common in the modern world. The analysis of the demonstrated medical history testifies to the negative impact of chronic kidney disease on the course of Covid infection. In addition, a significant effect on the prognosis in the treatment of an acute viral process of the stage of chronic renal failure is quite clearly traced. It is this factor, which determines the degree of an adequate response to the applied complex treatment of a new coronavirus infection, including the use of etiotropic, pathogenetic, symptomatic drugs. Modern treatment regimens for severe forms of a new coronavirus infection can improve the prognosis for this disease in people with chronic diseases of internal organs.
Бұл мақалада қазіргі әлемде жиі кездесетін, бірнеше дегенеративті аурулар салдарынан дамыған, аралас текті созылмалы бүйрек жеткіліксіздігінің аясында пайда болған жаңа коронавирусты инфекцияның ағымы мен ем ерекшеліктерінің клиникалық жағдайы келтірілген. Берілген сырқатнаманың талдауы барысында созылмалы бүйрек ауруы Ковид - инфекциясының ағымына кері әсерін тигізетінін көрсетті. Сонымен қатар, созылмалы бүйрек жеткіліксіздігінің ауырлық сатысы да жедел вирусты процесстің ем болжамына айқын ықпал ететінін байқатты. Дәл осы фактор, жаңа коронавирусты инфекцияның емінде қолданылатын күрделі этиотропты, патогенездік және симптоматикалық дәрілік заттардың әсерлі жауабының дәрежесін анықтайды. Жаңа коронавирусты инфекцияның ауыр түрлерінің заманауи емдеу кестелері созылмалы ішкі ағзалардың аурулары бар адамдарда осы аурудың болжамын жақсартуына мүмкіндік береді.
Summer School in Computational Physiology: A Collaborative Course in Modeling Excitable Tissues
Authors: McCabe Kimberly J. , Forsch Nickolas , Edwards Andrew G. , Maleckar Mary M. 
Published: October 2024

ABSTRACT
Computational modeling of physiology is a multiscale, multidisciplinary field requiring a diverse set of skills and backgrounds. The Simula Summer School in Computational Physiology aims to teach graduate students from around the world practical methods for multiscale modeling of excitable tissues (specifically, the heart and brain). This joint summer school is collaboratively based on the complementary expertise and shared educational goals of three institutions: Simula Research Laboratory, the University of Oslo, and the University of California San Diego. The summer school’s core goal is to promote successful research collaboration among the host institutions and to train excellent computational researchers. Keys to the success of this type of school include sustainable funding, close mentorship, and innovative, adaptive teaching tools. Using a combination of lectures, hands-on programming modules, and real-world projects in small groups with experienced scientific mentors, this unique program is an immersive way for young scientists to develop skills and network with future peers from around the world.
Effectiveness of a Three-Step Decoding Strategy with Constant Time-Delay to Teach Word Reading to Students with Mild and Moderate Intellectual Disability
Authors:   King Saud University,  Saudi Arabia, Al-Mawash Amjad , Al-Dosiry Norah ,   King Saud University,  Saudi Arabia
Published: October 2024

The purpose of this study was to examine the effects of a three-step decoding strategy with constant time delay on teaching and acquisition of decoding and word reading skills to four students with mild and moderate intellectual disability and to measure the generalization of those skills to untaught words. A multiple probe design across participants was used to examine the percentage of sounds correctly decoded and words correctly read. The results indicate that all four participants learned to decode and read words using the two strategies. Furthermore, all participants showed an increased learning efficiency in decoding and reading when teaching the second set of similar words. Generalization data showed that only two participants were able to decode and read some of the new words before teaching them, while all participants' ability to decode the letters of the new words was improved.	Keywords: Reading, Phonics, Three-step decoding, Time delay, Intellectual disability
Pemanfaatan Tanaman Stevia Sebagai Pemanis Alami Pengganti Gula
Authors: Cynthia Dewi Alina , Agripina Hadyanawati Anindya , Arum Asih Nur Sarinindiyanti Julin , Putra Harditriyono 
Published: October 2024

ABSTRAK Peningkatan prevalensi diabetes di masyarakat sering kali disebabkan oleh pola konsumsimakanan yang tidak sehat, terutama tingginya asupan minuman manis. Pola makan yangtidak sehat dapat memicu berbagai masalah kesehatan seperti obesitas, kanker, depresi,penyakit jantung, penurunan kognitif, dan gangguan metabolisme. Salah satu solusi yangdapat ditawarkan adalah penggunaan Stevia, tanaman asli Amerika yang memiliki kandungan pemanis alami. Stevia tidak hanya menjadi alternatif yang lebih sehat dibandingkan gula, tetapi juga memiliki berbagai aktivitas biologis yang bermanfaat. Konsumsi gula berlebih telah terbukti meningkatkan prevalensi diabetes, sehingga edukasi mengenai alternatif pemanis menjadi kebutuhan mendesak bagi masyarakat, termasuk di kawasan Limo. Melalui analisis kebutuhan masyarakat setempat, edukasi mengenai manfaat penggunaan Stevia sebagai pengganti gula serta pengetahuan mengenai konsumsi harian yang tepat dapat meningkatkan kesadaran masyarakat tentang pentingnya pola makan yang sehat. Kegiatan ini bertujuan memberikan pengetahuan kepada masyarakat tentang cara mengolah daun Stevia menjadi pemanis alternatif. Dengan demikian, diharapkan masyarakat dapat menerapkan kebiasaan makan yang lebih sehat dan mengurangi risiko penyakit terkait konsumsi gula berlebih.

ABSTRACT The increasing prevalence of diabetes in society is often caused by unhealthy eating patterns, particularly the high consumption of sugary drinks. Unhealthy diets can trigger various health issues such as obesity, cancer, depression, heart disease, cognitive decline, and metabolic disorders. One solution that can be offered is the use of Stevia, a native plant of America that contains natural sweeteners. Stevia not only serves as a healthier alternative to sugar but also offers various beneficial biological activities. Excessive sugar consumption has been proven to increase the prevalence of diabetes, making education on alternative sweeteners an urgent need for communities, including in the Limo area. Through an analysis of local community needs, education on the benefits of using Stevia as a sugar substitute and proper daily consumption knowledge can raise awareness about the importance of healthy eating habits. This initiative aims to equip the community with knowledge on how to process Stevia leaves into an alternative sweetener. Thus, it is hoped that the community will adopt healthier eating habits and reduce the risk of diseases related to excessive sugar consumption.
Pendampingan UMKM CHIPAO Dimsum di Alam Sutera
Authors: Gunawan Liphing , Alvonsius Hendra Nigel Alvonsius Hendra , Yen Wahyu Yen , Setiawan Budi 
Published: October 2024

ABSTRAKIndustri makanan dan minuman tidak hanya bergerak di perusahaan, tetapi juga bergerakdi Usaha Mikro Kecil dan Menengah atau yang biasa disebut UMKM. UMKM adalahsebuah usaha yang dijalankan, dikelola, dan dimiliki oleh perorangan atau badan usahayang telah memenuhi kriteria dan syarat-syarat sebagai usaha mikro. Untukmempertahankan UMKM di industri makanan dan minuman, diperlukannya memilikistrategi promosi. Sebagai mahasiswa program Studi Pariwisata, penulis mendapati bahwaUMKM CHIPAO Dimsum perlu pembimbingan untuk mengembangkan promosi agardapat meningkatkan penjualan dan dapat bersaing dengan usaha lain. Metode penelitianyang digunakan penulis adalah penelitian kualitatif dengan melakukan observasi, lalumenganalisis data hasil observasi. Hasil dari upaya tersebut adalah pemilik usahatermotivasi untuk bergerak secara maksimal dalam promosi usahanya.

ABSTRACTThe food and beverage industry is not only engaged in companies, but also in Micro,Small and Medium Enterprises or what is commonly called MSMEs. MSME is a businessthat is run, managed, and owned by an individual or business entity that has met thecriteria and requirements as a micro business. To maintain MSMEs in the food andbeverage industry, it is necessary to have a promotional strategy. As a student of theTourism Study program, the author finds that CHIPAO Dimsum MSMEs need guidance todevelop promotions in order to increase sales and be able to compete with otherbusinesses. The research method used by the author is qualitative research by makingobservations, then analyzing the data from the observations. The result of these efforts isthat the business owner is motivated to move optimally in the promotion of his business.
Circumbinary Disk Spectra Irradiated by Two Central Accretion Disks in a Binary Black Hole System
Authors: Lee Yunewoo , Okazaki Atsuo T. , Hayasaki Kimitake 
Published: October 2024

Abstract
We study the effect of irradiation from two accretion disks (minidisks) around respective black holes of stellar-to-intermediate masses in a circular binary on the spectrum of a circumbinary disk (CBD) surrounding them. We assume the CBD to be a standard disk and adopt the orbit-averaged irradiation flux because the viscous timescale is much longer than the orbital period. We then solve the energy equation both analytically and numerically to compute the CBD temperature distribution and the corresponding disk spectrum. We find that the analytically calculated spectra are in good agreement with the numerical ones. The CBD spectrum is almost independent of the binary mass ratio. We also find that the combined spectra of two minidisks and the CBD have double peaks, one peak in the soft X-ray band and the other in the infrared (IR) band. The former peak comes from the two minidisks, while the latter peak from the CBD. The observed flux density increases with frequency as ν
1/3 toward the soft X-ray peak, while it decreases with frequency away from the IR peak as ν
−5/3. The latter feature is testable with near-IR observations with Subaru and JWST.
Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale
Authors: Matzner Christopher D. 
Published: October 2024

Abstract
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable. In this state, the sonic mass scale, which influences the peak of the stellar mass function, is tied to a fundamental scale composed of the Planck mass and the mass per particle. Thermal feedback also affects the opacity-limited minimum mass and how protostellar outflows and binary fragmentation modify stellar masses. Considering the regions that collapse to form massive stars, we argue that thermal stabilization is likely to flatten the high-mass slope of the initial mass function. Among regions that are optically thick to thermal radiation, we expect the stellar population to become increasingly top-heavy at higher column densities, although this effect can be offset by lowering the metallicity. A toy model is presented that demonstrates these effects and in which radiation pressure leads to gas dispersal before all of the mass is converted into stars.
Potential Chronological Disturbance of the D’Orbigny Angrite Inferred from Discordant 26Al Ages
Authors: Deligny Cécile , Piralla Maxime , Villeneuve Johan , Füri Evelyn , Marrocchi Yves 
Published: October 2024

Abstract
Angrites originate from the early-formed differentiated angrite parent body. The pristine volcanic angrite D’Orbigny is devoid of brecciation, shock effects, or any evidence of secondary processes and is thus key for studying the early stages of planetary accretion and differentiation. However, chronometers used to establish the formation chronology of angrites (including D’Orbigny) yield discordant ages, either (i) suggesting that secondary processes could have disturbed the apparent formation ages or (ii) being taken as evidence of heterogeneous distribution of 26Al in the early solar system. Yet spinel is minimally susceptible to secondary parent body processes and therefore a reliable target for establishing precise 26Al–26Mg ages. Here, we present the first in situ 26Al–26Mg analyses of spinel and plagioclase in D’Orbigny. Individual mineral assemblages provide distinct ages: olivine–spinel shows a well-defined isochron with an initial Al ratio ([26Al/27Al]i) of (5.39 ± 0.85) × 10−6, indicating formation at 2.35

+
0.25

−
0.22

Myr after the formation of calcium–aluminum-rich inclusions (CAIs), whereas plagioclase–olivine defines an isochron with [26Al/27Al]i = (7.46 ± 1.87) × 10−7, implying formation at 4.40

+
0.44

−
0.38

Myr after CAIs, consistent with previous MC-ICP-MS studies. This temporal gap can be attributed to secondary processes such as metamorphic or impact-generated diffusion. Thus, D’Orbigny and other angrites do not represent an immaculate anchor for chronometric comparison. This complexity should be considered in future studies, especially when using D’Orbigny as an anchor to discuss the chronology of the early solar system.