bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical approbation of biologically active supplement in patients with vegetovascular dystonia
Authors: Vekovtsev A. A. , Podzorova G. A. , Poznyakovsky V. M. 
Published: January 2019

Aim. To study the possibility of using and estimate the efficiency of a new tablet form of biologically active supplement in patients with vegetovascular dystonia syndrome.
Materials and methods. One hundred patients with vegetovascular dystonia syndrome, including 50 patients of the main group and 50 patients of the control group were examined. There is presented the composition of prescription formula of biologically active supplement, based on participation of its components in the correction of disturbed metabolic processes of the nervous system.
Results. Additional application of biologically active supplement in combination with drug significantly improves cerebral blood flow, decreases blood viscosity and risk of cellular membrane impairment, normalizes arterial pressure, elevates initiative and attention, reduces headache in patients of the main group with vegetovascular dystonia syndrome.
Conclusions. Use of biologically active supplement has a positive effect in complex therapy of patients with vegetovascular dystonia syndrome.
The Relationship of Smoking, Alcohol, and Drugs Consumption on the Quality of Semen Parameters in Males referring to the Infertility Center of Yazd in 2016
Authors: Shafabakhsh Marjan , Sadeghian HosseinAli , Ehramposh Mohammad Hassan , Aflatonian Abas , Dehghani Arefeh , Taghi Ghaneian Mohamad 
Published: January 2019

Introduction: Male infertility has increased during recent years in countries of the world including Iran. Among many factors that influence the infertility, smoking, alcohol, and addictive drugs were investigated in this study.
Methods: This case-control retrospective study was conducted on 600 male patients consisting of 300 individuals with natural semen and 300 people with defective semen. The first step in investigation of infertility in each couple was to conduct a spermogram to detect the male infertility. The case group included men who referred to the Yazd Infertility Treatment Center and had at least one abnormal test result among considering the parameters of semen test. The control group included the men who referred to the same center and had normal semen test result. The data collection tools were a researcher-made checklist based on the parameters required for the study with epidemiological and observational design, as well as the semen analysis test.
Results: The age mean in the case and control groups were 34.71 and 33.82 years with the standard deviation of ± 7.3 and ± 6.41, respectively. The means of marriage age in the case and control groups were 26.28 and 26.28 ±5.3 years, respectively. The mean duration of infertility in the case group was 6.30 ± 4.60 and in the control group was 5.15± 3.88. No significant difference was observed between the mean age (P = 0.084) and marital age (P = 0.448) in two groups, but the mean duration of infertility (P <0.001) was significantly different between the two groups .The prevalence of smoking was significantly different between the two groups (P = 0.032). Considering the daily frequency of smoking, the highest rate was 11-20 cigarettes in both groups (case group 21.7% and control group 15.3%). The P value was set at 0.018.
Conclusion: In this study, smoking and consumption of alcohol were not considered as the predictive factors of semen quality, but consumption of drugs and the age of starting consumption of drugs had a significant relationship with the semen disorders.
Knowledge, Attitude, and Practice toward Protection of Cooling Systems (Refrigerator and Freezer) and Control of Ozone - Depleting Gases Emission into the Environment among Health Volunteers in Yazd
Authors: Rezaeipandari Hassan , Amanalikhani Shabnam , Ghaneian Mohammad Taghi , Amrollahi Mohsen , Soltanianzadeh Zahra 
Published: January 2019

Introduction: Chlorofluorocarbons are one of the most important ozone-depleting substances used as coolant gases in refrigerators and freezers in developing countries such as Iran. The objective of this study was to determine the knowledge, attitude, and practice toward the protection of cooling systems and control of ozone-depleting gases emission into the environment among health volunteers in Yazd city, Iran.
Methods: This descriptive and cross-sectional study was conducted on 110 health volunteers in Yazd in 2014. The data collection tool was a researcher-made questionnaire containing four parts of demographic data, knowledge, attitude, and practice of health volunteers. The data were analyzed by descriptive tests, ANOVA, and Pearson correlation.
Results: The mean scores of knowledge, attitude, and practice of health volunteers were 8.12 ± 4.02 (range 0-23), 66.82 ± 7.55 (range 19-95), and 8.21 ± 1.47 (range 0-12). A positive and significant correlation was also observed between the three variables of knowledge, attitude, and practice of volunteers regarding the protection of cooling systems and controlling the emission of ozone-depleting gases into the environment (p <0.05).
Conclusion: The knowledge of health volunteers, as an effective stratum in the knowledge, attitude, and practice of the community, about depletion of the ozone layer, as one of the most important environmental issues, was not at an appropriate level. Therefore, educating and promoting the knowledge level of health volunteers is of great importance as the most basic part of making health behaviors.
IDENTIFICATION OF HUNTETE BEACH TOURISM OBJECT IN KULATI VILLAGE EAST TOMIA SUB-DISTRICT WAKATOBI REGENCY
Authors: Sejati Andri Estining , Amaluddin La Ode , Ihsan Fahrudi Akhwan , - Mutiana 
Published: January 2019

Huntete Beach has good physical potention, but still not optimal visitors. The purposes of this paper there are two (a) to determine the potention of Huntete Beach tourism objects in Kulati Village, East Tomia Subdistrict, Wakatobi Regency, (b) To find out the perception of tourists on the potential of Huntete Beach tourism objects in Kulati Village, East Tomia District, Wakatobi Regency. This research uses survey method. The results of this paper are (a) the potential of Huntete Beach is in the medium category (internal potential) and low (external potential), so it needs to be developed again so that it can become a main tourism object in East Tomia Subdistrict, Wakatobi Regency, (b) Presumption from tourists who visit that there is a potential in Huntete Beach tourism, so needs better management by completing facilities that are not yet available. It can tourists more enjoy the natural phanorama and not feel bored at this place.
Keywords: potential identification, tourism object, Huntete beach
Patrones de distribución de la oferta turística mediante técnicas geoestadísticas en Extremadura (2004-2014)
Authors: Sánchez Martín José Manuel , Sánchez Rivero Marcelino , Rengifo Gallego Juan Ignacio 
Published: January 2019

<p>El rápido incremento de la oferta de alojamientos en Extremadura no se ha visto correspondido con un aumento armónico en el número de visitantes y de pernoctaciones, hecho que ha provocado un desajuste notable entre la oferta y la demanda. El aumento de oferta se ha producido de forma desigual sobre el territorio, por lo que esta investigación pretende determinar los patrones de distribución que se detectan en los tres grandes grupos de oferta: hotelera, extrahotelera y rural, así como su evolución. Para conseguirlo, se utilizaron tanto el análisis de clúster y de valor atípico (LISA) como el análisis de puntos calientes y fríos (GI* de Getis-Ord). Ambas técnicas corroboran que los cambios detectados en la oferta de alojamientos siguen pautas similares y demuestran que la proximidad espacial no tiene un carácter espurio. Todo ello confirma el contrapuesto desarrollo turístico de Extremadura.</p>
Study of the Heat Transfer in the Wellbore During Acid/Hydraulic Fracturing Using a Semianalytical Transient Model
Authors: Peng Yu , Zhao Jinzhou , Sepehrnoori Kamy , Li Yibo , Yu Wei , Zeng Ji 
Published: January 2019

Summary
Bottomhole-temperature variations have a significant influence on the rheological properties of fracturing fluid and the reaction rates of rock and acid in the operations of acid/hydraulic fracturing. In this work, a semianalytical model is developed for calculating the heat transfer in a wellbore under transient state. In the model, transient heat conduction in the cement sheath and forced convection in the tubing under different flow regimes are considered. Also in this model, calculation methods of heat-transfer coefficients of forced convection in the tubing and natural convection in the annulus are improved in relation to the existing methods. The semianalytical model is verified by monitoring the data of acid and hydraulic fracturing; it is accurate enough to estimate the physical properties of the fracturing fluid and perform simulations in the reservoirs. We studied transient heat conduction in a cement sheath, the influence of flow regimes on tubing, the variation of thermal properties in the wellbore, and the influence of vertical variations of rock type. Simulation results show that the influence of different heat-transfer states of the cement sheath on bottomhole temperature is much more significant under the injection rate of fracturing. Laminar flow is activated by extremely low injection velocity or low temperature in shallow layers. However, such low velocity can never be attained in the fracturing operation. Also, the high heat resistance caused by laminar flow in shallow layers cannot affect the bottomhole temperature significantly because of the low temperature difference between fracturing fluid and formation rock. We also found that the complex vertical variation of rock type and shale and sandstone interbedding could be approximated by the average temperature of simple models that are computationally faster and have an acceptable range of errors.
Anesthetics to Prevent Lung Injury in Cardiac Surgery (APLICS): A protocol for a randomized, controlled trial
Authors: O’Gara Brian P. , Subramaniam Balachundhar , Shaefi Shahzad , Mueller Ariel , Banner-Goodspeed Valerie , Talmor Daniel 
Published: January 2019

Abstract
Background
Patients undergoing cardiac surgery with cardiopulmonary bypass are at an increased risk of developing postoperative pulmonary complications, potentially leading to excess morbidity and mortality. It is likely that pulmonary ischemia-reperfusion (IR) injury during cardiopulmonary bypass is a major contributor to perioperative lung injury. Therefore, interventions that can minimize IR injury would be valuable in reducing the excess burden of this potentially preventable disease process. Volatile anesthetics including sevoflurane have been shown in both preclinical and human trials to effectively limit pulmonary inflammation in a number of settings including ischemia-reperfusion injury. However, this finding has not yet been demonstrated in the cardiac surgery population. The Anesthetics to Prevent Lung Injury in Cardiac Surgery (APLICS) trial is a randomized, controlled trial investigating whether sevoflurane anesthetic maintenance can modulate pulmonary inflammation occurring during cardiac surgery with cardiopulmonary bypass, and whether this potential effect can translate to a reduction in postoperative pulmonary complications.
Methods
APLICS is a prospective, randomized controlled trial of adult cardiac surgical patients. Subjects will be randomized to receive intraoperative anesthetic maintenance with either sevoflurane or propofol. Patients in both groups will be ventilated according to protocols intended to minimize the influences of ventilator induced lung injury and hyperoxia. Bronchoalveolar lavage (BAL) and blood sampling will take place after anesthetic induction and between two to four hours after pulmonary reperfusion. The primary outcome is a difference between groups in the degree of post-bypass lung inflammation, defined by BAL concentrations of TNFa. Secondary outcomes will include differences in additional relevant BAL and systemic inflammatory markers and the incidence of postoperative pulmonary complications.
Discussion
APLICS investigates whether anesthetic choice can influence lung inflammation and pulmonary outcomes following cardiac surgery with cardiopulmonary bypass. A positive result from this trial would add to the growing body of evidence describing the lung protective properties of the volatile anesthetics and potentially reduce unnecessary morbidity for cardiac surgery patients.
Trial Registration
ClinicalTrials.gov identifier NCT02918877, registered on September 29, 2016.
Sensory Integration Therapy Versus Usual Care for Sensory Processing Difficulties in Autism Spectrum Disorder in Children: Study Protocol for a Pragmatic Randomised Controlled Trial
Authors: Randell Elizabeth , McNamara Rachel , Delport Sue , Busse Monica , Hastings Richard , Gillespie David , Williams-Thomas Rhys , Brookes-Howell Lucy , Romeo Renee , Boadu Janet , Ahuja Alka S , McKigney Anne Marie , Knapp Martin , Smith Kathryn , Thornton Jacqui , Warren Gemma 
Published: January 2019

Abstract
Background:
Autism Spectrum Disorder (ASD) is a common lifelong condition affecting 1 in 100 people. ASD affects how a person relates to others and the world around them. Difficulty responding to sensory information (noise, touch, movement, taste, sight) is common, and might include feeling overwhelmed or distressed by loud or constant low-level noise (e.g. in the classroom). Affected children may also show little or no response to these sensory cues. These ‘sensory processing difficulties’ are associated with behaviour and socialisation problems, and affect education, relationships, and participation in daily life. Sensory Integration Therapy (SIT) is a face-to-face therapy or treatment, provided by trained occupational therapists who use play -based sensory-motor activities and the just-right challenge to influence the way the child responds to sensation, reducing distress, and improving motor skills, adaptive responses, concentration and interaction with others. With limited research into SIT, this protocol describes in detail how the intervention will be defined and evaluated.
Methods:
Two-arm pragmatic individually 1:1 Randomised Controlled Trial (RCT) with internal pilot of SIT versus Usual Care (UC) for primary school aged children (4 to 11 years) with ASD and Sensory Processing (SP) difficulties. 216 children will be recruited from multiple sources. Therapy will be delivered in clinics meeting full fidelity criteria for manualised SIT over 26 weeks (face-to-face sessions: 2 per week for 10 weeks, 2 per month for 2 months; Telephone call: 1 per month for 2 months). Follow up assessments will be completed at 6 and 12 months post randomisation. Prior to recruitment: therapists will be invited to participate in focus groups/interviews to explore what is delivered as usual care in trial regions; carers will be invited to complete an online survey to map out their experience of services. Following recruitment: carers will be given diaries to record their contact with services. Following intervention, carer and therapist interviews will be completed.
Discussion:
Results of this trial will provide high quality evidence on the clinical and cost-effectiveness of SIT aimed at improving behavioural, functional, social, educational and well-being outcomes for children and well-being outcomes for carers and families.
Trial registration:
ISRCTN14716440. Registered 08/11/2016. http://www.isrctn.com/ISRCTN14716440
An Assessment of the Multifunctionality of Integrated Buffer Zones in Northwestern Europe
Authors: Zak Dominik , Stutter Marc , Jensen Henning S. , Egemose Sara , Carstensen Mette V. , Audet Joachim , Strand John A. , Feuerbach Peter , Hoffmann Carl C. , Christen Benjamin , Hille Sandra , Knudsen Mads , Stockan Jenni , Watson Helen , Heckrath Goswin , Kronvang Brian 
Published: January 2019

Integrated buffer zones (IBZs) have recently been introduced in the Northwestern Europe temperate zone to improve delivery of ecosystem services compared with the services associated with long‐established vegetated buffer zones. A common feature of all the studied IBZ sites is that tile drainage, which previously discharged directly into the streams, is now intercepted within the IBZ. Specifically, the design of IBZs combines a pond, where soil particles present in drain water or surface runoff can be deposited, and a planted subsurface flow infiltration zone. Together, these two components should provide an optimum environment for microbial processes and plant uptake of nutrients. Nutrient reduction capacities, biodiversity enhancement, and biomass production functions were assessed with different emphasis across 11 IBZ sites located in Denmark, Great Britain, and Sweden. Despite the small size of the buffer zones (250–800 m2) and thus the small proportion of the drained catchment (mostly <1%), these studies cumulatively suggest that IBZs are effective enhancements to traditional buffer zones, as they (i) reduce total N and P loads to small streams and rivers, (ii) act as valuable improved habitats for aquatic and amphibian species, and (iii) offer economic benefits by producing fast‐growing wetland plant biomass. Based on our assessment of the pilot sites, guidance is provided on the implementation and management of IBZs within agricultural landscapes.Core Ideas
Integrated buffer zones are a novel edge‐of‐field approach within riparian zones.
Drain water and surface runoff will be trapped within a pond and charge a filter bed.
The inclusion of trees aims to provide some of the benefits of riparian forests.
Soil Water Retention: Uni‐Modal Models of Pore‐Size Distribution Neglect Impacts of Soil Management
Authors: Jensen Johannes L. , Schjønning Per , Watts Christopher W. , Christensen Bent T. , Munkholm Lars J. 
Published: January 2019

Core Ideas
A uni‐ and a bi‐modal soil water retention model were evaluated.
The bi‐modal double‐exponential model fitted better to soil pore‐size distribution.
The uni‐modal model fit was affected by texture, soil organic C, and tillage.
Uni‐modal models are not well suited for describing the pore‐size distribution.
Most models describing soil water retention imply a uni‐modal pore‐size distribution (PSD). The uni‐modal model presented by van Genuchten (termed vanG) is widely used although double‐exponential models (termed Dex) implying a bi‐modal PSD may better reflect reality. We tested the ability of vanG and Dex models to represent water retention in sandy top‐ and subsoils with different texture, in soil with contrasting management (Highfield), and in soil exposed to different tillage (Flakkebjerg). Soils were subjected to matric potentials from –10 hPa to –1.5 MPa. For all soils, the bi‐modal Dex model showed a better fit to water retention data than the uni‐modal vanG model. Neither of the models worked well for highly sorted soils. The vanG model gave a poorer fit for topsoils than for subsoils because of a more pronounced bi‐modality of the PSD in topsoils caused by larger soil organic carbon (SOC) content and tillage. For Highfield soils, the root mean squared error (RMSE) of the vanG fit increased from long‐term bare fallow (low C content, intensive tillage) to permanent grass (high C content, no tillage) reflecting a more distinct bi‐modality of the PSD for well‐structured soils. We conclude that uni‐modal models should be used with great caution when describing effects of texture and management on PSD and that bi‐modal models may provide a better fit to PSD.
Novel Fluorine Boron Hybrid Complex as Potential Antiproliferative Drugs on Colorectal Cancer Cell Line
Authors: Tülüce Yasin , Masseh Hawro D.I. , Koyuncu İsmail , Kiliç Ahmet , Durgun Mustafa , Özkol Halil 
Published: January 2019

Objective:
Colorectal Cancer (CRC) is one of the most common types of cancer in both sexes; it is
considered to be the third leading death factor among other types of cancer.

:
This study aimed to examine the cytotoxicity of a new fluorine boron hybrid complex [L(BF2)2] on human
colorectal adenocarcinoma cell line (HT-29), based on the potency of the half-metal based complexes to initiate
apoptosis.

Methods:
Methods: Based on this data, the impact of it in different concentrations on HT-29 cancerous cells was
determined by apoptosis (ELISA, DNA fragmentation laddering, AO/EB staining), cytotoxicity (MTT) and
genotoxicity (comet assay). We also calculated the cellular Oxidative Stress Index (OSI) by measuring the Total
Antioxidant Status (TAS) and Total Oxidant Status (TOS).

Results:
Firstly, [L(BF2)2] was examined in view of cytotoxic effect in seven various cell lines (HELA, DU-145,
PC3, DLD-1, ECC, PNT1-A and HT-29), and then it was found that the applied complex had a mighty
antiproliferative action on HT-29 cells. Thus, the most effective IC50 value turned out to be 26.49 µM in HT-29
cell line. The present study found a tremendous efficacy of [L(BF2)2] on HT-29 cells, especially in terms of
damage to cancer cells' DNA, and consequently caused a series of reactions leading to programmed cell death.

Conclusion:
The results suggest that the [L(BF2)2] as a novel fluorine boron hybrid complex can induce the
apoptosis of HT-29 colorectal cancerous cell line and is a possible candidate for future cancer studies.
Trichomonas Vaginalis Infection Among Women Attending Laboratory Centers in Ilam, Iran
Authors: Nikpay Sasan , Otaghi Masoumeh , Azami Milad , Karimi Marzieh , Abdi Jahangir 
Published: January 2019

Background:
Trichomoniasis is known as a common venereal disease. It is estimated
that 180 million people in the world are infected with this disease. The present study was conducted
to estimate the prevalence of (Trichomonas vaginalis) T. vaginalis among women who
were referred to the central laboratory in Ilam.

Methods:
In this cross-sectional study, 481 women with suspicious symptoms of trichomoniasis
were selected during the first six months of 2015 in the central laboratory and Shahid Mostafa
laboratory in Ilam, Iran. All patients were referred to the labs by gynecologists. Sterile swabs were
used to collect direct smears. The results and questionnaire data were entered into SPSS version
16 and were analyzed using chi-square test and Fisher's exact test.

Results:
Direct smear of T. vaginalis demonstrated seven positive cases (1.5%). The highest and
the lowest percentages of T. vaginalis infection in women were related to the 45-50 and 20-30
years age groups, respectively. Illiterate women had the highest percentage of infection. No significant
relationship was found between the level of education and trichomoniasis infection in
women (p = 0.085). The highest infection rate was associated with the use of ectopic contraceptive
methods (condoms).

Conclusion:
The prevalence of T. vaginalis was low among women in Ilam but was high among
women who have used tubal ligation and condom to prevent pregnancy. Therefore, more attention
is required from healthcare centers for appropriate education to women about the proper use of
protective equipment.