bluuebunny/crossref_metadata_2025_split huggingface dataset:
Project G-SPACE: protocol for exploring the influence of green space on sleep and mental health among children
Authors: Grigsby-Toussaint Diana S. , Shin Jong Cheol , Acevedo Aliana Rodriguez , Kemball-Cook William , Story Diane , Katz Abby , Nwanaji-Enwerem Ugoji , Evans Gabrielle , Johnson Azia , Ury Brooke , Romero-Ramos Yaideliz M. , Yang Jue , Barker David M. , McGeary John E. , Dunsiger Shira I. 
Published: November 2024

Abstract
Background
The prevention of pediatric mental health disorders is a growing health priority in the United States. While exposure to green space, such as outdoor vegetation, has been linked with improved mental health outcomes in children, little is known about the impact of green space on children’s sleep. Sleep has many benefits, but the factors affecting both sleep and mental health as they relate to green space exposure are not well understood in children. This study aims to investigate how green space can affect sleep in children and contribute to the promotion of mental health and wellbeing.

Methods
Project Green Space, Sleep, and Mental Health (G-SPACE) aims to recruit 250 elementary school-children from first, second, and third grade in Rhode Island to examine the influence of green space exposure on sleep, physical activity, and mental health over a five-year period. Objective measures of sleep, physical activity, and daily activity space will be assessed using an actigraph and a GPS (Global Positioning System) unit. Subjective measures of sleep duration, sleep quality, and mental health will be assessed using daily sleep diaries from parents, in addition to a range of survey items, including PROMIS® (Patient Reported Outcome Measurement Information System) pediatric scales, and the Children’s Sleep Habits questionnaire, among others. Green space exposure will be based on measures of green space from the normalized difference vegetation index (NDVI) aligned with the daily activity trajectory of children. Additionally, saliva and DNA samples will be collected to examine epigenetic mechanisms linking green space to sleep and mental health. A subset of participants (n = 50) will be followed longitudinally to evaluate the long-term impact of green space on sleep and mental health among children. Multi-level models will be used to assess the association between green space exposure, sleep behaviors, and mental health.

Discussion
Project G-SPACE will evaluate whether green space utilization influences sleep and mental health in early elementary school children, and the possible mechanistic pathways through which these associations emerge.
Self-harm hospitalizations and neighbourhood level material and social deprivation in Canada: an ecological study
Authors: Liu Li , Pollock Nathaniel J. , Contreras Gisèle , Xu Yuan , Thompson Wendy 
Published: November 2024

Abstract
Background
Socio-economic status is associated with self-harm at the individual and area level. In Canada, there is limited evidence on the relationship between area-level markers of socio-economic status and self-harm. The objective of this study was to assess the impact of small area-level material and social deprivation on rates of hospitalization due to self-harm.

Methods
Administrative data on hospitalizations from two databases in Canada (Discharge Abstract Database and Ontario Mental Health Reporting System) for the period April 1, 2015 to March 31, 2022, were analyzed. Rates of self-harm hospitalization and percentage of repeated admissions were estimated across quintiles of material and social deprivation. Rate ratios were computed to evaluate disparities. The rates were stratified by sex and age group; the percentage of repeated admissions were stratified by sex.

Results
In total, the study included 109,398 hospitalizations due to self-harm. Populations in more deprived areas had higher rates of self-harm hospitalizations than those in less deprived areas. The rate ratios for people who lived in the most deprived areas over the least deprived areas were 1.48 (95% CI: 1.38–1.58) and 1.71 (95% CI: 1.60–1.82) for material and social deprivation, separately. The largest disparity was among people aged 25–44 years for material and 45–64 years for social deprivation. Percentages of repeated self-harm hospitalizations were significantly higher in more deprived areas compared to less deprived areas for social deprivation, and among males but not females for material deprivation.

Conclusions
Both material and social deprivation were associated with self-harm hospitalization and repeated admissions; the disparity varied by subgroup and the deprivation components. This study demonstrated a need to consider interventions at the neighbourhood level and address both community and population-level conditions of social and material need.
Assessing fidelity of design and training of Making Every Contact Count (MECC) in a mental health inpatient setting
Authors: Kemp Emma , Aquino Maria Raisa Jessica , Wilson Rob , Vasiljevic Milica , McBride Kate , Robson Craig , Faulkner Sally , Loraine Mish , Harland Jill , Haighton Catherine , Rodrigues Angela 
Published: November 2024

Abstract
Background
Making Every Contact Count (MECC) is a public health strategy which strives to enable brief interventions to be implemented through opportunistic healthy lifestyle conversations. In a mental health inpatient setting a bespoke MECC training package has been developed to encourage cascade training through a train the trainer model and to incorporate an additional regional health strategy A Weight Off Your Mind into Core MECC training to provide a focus on healthy weight management. This study evaluated the fidelity of design of MECC in the mental health inpatient setting and fidelity of the training package currently being cascaded across the region.

Methods
Initially a documentary analysis of six documents shared through the mental health inpatient setting including MECC implementation guide, logic model, checklist and evaluation framework. Documents were analysed using the Template for Intervention Description and Replication (TIDieR) checklist and coded using the Behaviour Change Technique (BCT) Taxonomy version one (BCTTv1) and the Expert Recommendations for Implementing Change (ERIC) Taxonomy. Coding was compared against MECC guidance documents to complete the fidelity assessment. A training delivery guide, training slides and two recordings of both train the trainer and Core MECC + A Weight Off Your Mind training were analysed for behaviour change techniques (BCTs) and compared to conduct a fidelity training assessment.

Results
Overall the implementation of MECC in the mental health inpatient setting had moderate fidelity to the MECC guidance, with a total of 31 BCTs identified across guidance and provider documents and a 77% adherence of provider documents to guidance. The highest level of fidelity applied to the MECC implementation guide where 86% of identified BCTs were also present. The training package showed high fidelity that both training programmes were being delivered as intended with 100% of BCT matched from training materials to training transcripts. Potential loss of fidelity through additional BCTs was present across provider documents and training transcripts.

Conclusion
The implementation of MECC across the mental health inpatient setting and the training package appear to be delivered as intended therefore demonstrating good fidelity and potential benefits to public health. Future research would benefit from assessing cascade training sessions from those who have completed train the trainer to evaluate ongoing fidelity of training across the trust.
The association between chronotype and social anxiety among Chinese university students: a moderated mediation analysis of loneliness and perceived social support
Authors: Zhu Yingying , Liu Junling , Chen Fulin , Wang Qian , Cao Kunxia , Huang Jiahao , Wang He , Wang Qiang , Luo Xue 
Published: November 2024

Abstract
Background
Social anxiety has been a burning problem among contemporary college students in China. Increasing evidence suggests that individual circadian typology–chronotype may play an important role in the development of social anxiety. However, little research has focused directly on examining the association between chronotype and social anxiety, and less is known about the mediating and moderating mechanisms underlying this relationship. The aim of the present study was to investigate the link between chronotype and social anxiety among Chinese college students, and to explore the mediating effect of loneliness and the moderating effect of perceived social support in the association between chronotype and social anxiety.

Methods
A cross-sectional design was conducted among 1616 college students (16–29 years old) from several public universities in Northern China, including 1172 females (72.52%) and 444 males (27.48%), with an average age of 19.68 years old (SD = 1.49). All participants completed the standardized self-report questionnaires including the Social Avoidance and Distress Scale, Morningness-Eveningness Questionnaire, UCLA Loneliness Scale, and the Perceived Social Support Scale. Common method bias was performed using Harman’s single-factor test. The mediation and moderation effects were analyzed using SPSS software and PROCESS macros.

Results
Chronotype had a negative predictive effect on social anxiety in college students. Specifically, the greater the inclination of individuals' chronotypes toward evening preference, the more pronounced their symptoms of social anxiety would be. Loneliness served as a partial mediator in the relationship between chronotype and social anxiety, accounting for 30.0% of the total effect. In addition, perceived social support, particularly from friends and significant others, was found to play a moderating role in the process of loneliness affecting social anxiety among college students, while support from family did not. Interestingly, the perceived social support displayed a limited protective effect when college students suffered from higher levels of loneliness.

Conclusion
These findings deepened our understanding of how and when (or for “whom”) chronotype is related to social anxiety, offering a theoretical foundation and practical insights for preventing and addressing social anxiety risk in young adult university students, particularly those with evening chronotypes.
Analyzing evaluation methods for large language models in the medical field: a scoping review
Authors: Lee Junbok , Park Sungkyung , Shin Jaeyong , Cho Belong 
Published: November 2024

AbstractBackgroundOwing to the rapid growth in the popularity of Large Language Models (LLMs), various performance evaluation studies have been conducted to confirm their applicability in the medical field. However, there is still no clear framework for evaluating LLMs.ObjectiveThis study reviews studies on LLM evaluations in the medical field and analyzes the research methods used in these studies. It aims to provide a reference for future researchers designing LLM studies.Methods & materialsWe conducted a scoping review of three databases (PubMed, Embase, and MEDLINE) to identify LLM-related articles published between January 1, 2023, and September 30, 2023. We analyzed the types of methods, number of questions (queries), evaluators, repeat measurements, additional analysis methods, use of prompt engineering, and metrics other than accuracy.ResultsA total of 142 articles met the inclusion criteria. LLM evaluation was primarily categorized as either providing test examinations (n = 53, 37.3%) or being evaluated by a medical professional (n = 80, 56.3%), with some hybrid cases (n = 5, 3.5%) or a combination of the two (n = 4, 2.8%). Most studies had 100 or fewer questions (n = 18, 29.0%), 15 (24.2%) performed repeated measurements, 18 (29.0%) performed additional analyses, and 8 (12.9%) used prompt engineering. For medical assessment, most studies used 50 or fewer queries (n = 54, 64.3%), had two evaluators (n = 43, 48.3%), and 14 (14.7%) used prompt engineering.ConclusionsMore research is required regarding the application of LLMs in healthcare. Although previous studies have evaluated performance, future studies will likely focus on improving performance. A well-structured methodology is required for these studies to be conducted systematically.
Use of antipsychotic drugs during radiotherapy in adult cancer patients in Korea: a nationwide retrospective cohort study based on the national health insurance service database
Authors: Hwang In Gyu , Park Song E , Kim Sun Mi , Kang Dae Ryong , Go Tae-Hwa , Hong Se Hwa , Ha Yong-Chan , Park Shin Young , Lee Hyunho , Choi Jin Hwa 
Published: November 2024

Abstract
Background
Antipsychotic drugs (APDs) are used for treating mental illnesses and are also used by cancer patients. This study aimed to evaluate APD use in adult cancer patients who received radiotherapy (RT) in South Korea and assess the effects of APD use during RT on survival.

Methods
This retrospective cohort study utilized the National Health Insurance Service database database of Korea. We included adult cancer patients who underwent RT or chemotherapy (CTx, cisplatin, or 5-Fluorouracil) between 2010 and 2020. The APDs included in the analysis were aripiprazole, quetiapine, olanzapine, risperidone, haloperidol, and chlorpromazine.

Results
Overall, 725,897 patients received RT, and 115,500 received concomitant chemo-radiotherapy (CCRT). Of them, 41,118 (5.6%) took APDs during RT, and 8,129 (7%) took APDs during CCRT. Overall, 27,789 (67.58%) patients who took APDs during RT were men, and 28,004 (68.2%) were aged ≥ 60 years. The most frequently used APD during RT was quetiapine (64.93%). Patients who took APDs during RT and during CCRT had higher mortality rates (HR: 3.45 and 1.72, p < 0.0001, respectively) compared to the non-APD patients. Of the patients who used APDs during RT, patients accompanying psychiatric diagnosis, taking high-dose APD, and taking APD for more than 3 months had lower mortality than patients without psychiatric diagnosis, taking low-dose APD, and taking APD for less than 3 months, respectively (HR: 0.88, 0.87 and 0.80, respectively, p < 0.0001).

Conclusions
Only 5.6% of patients who underwent RT used APDs, and quetiapine was the most frequently prescribed APD during RT. The use of APD during RT may adversely affect survival. Further studies are required to elucidate the effects of APDs on cancer patients.

Trial registration
This study is retrospectively registered.
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction
Authors: Miyamoto Daisuke , Mahmoud Mahmoud Abdelmouti 
Published: November 2024

AbstractTrace and delay auditory fear conditioning involve different memory association strategies based on working memory involvement; however, their differences in long-term processing through sleep and extinction training remain unclear. While females often exhibit more persistent fear, complicating psychiatric treatment, most studies have primarily focused on how sleep affects initial recall in male mice. We investigated the three-way interaction between tests (trace vs. delay), sleep states, and sex during initial recall, extinction, and post-extinction remote recall. A six-hour post-conditioning sleep deprivation (SD) did not affect freezing behavior during the following day’s extinction training of delay fear memory. However, during post-extinction remote recall of delay fear memory, SD prevented spontaneous recovery in males and reduced persistent freezing in females. In contrast, SD rapidly facilitated extinction of trace fear memory. In summary, SD enhances extinction both in the short-term and long-term, depending on the conditioning protocol. These findings highlight the importance of long-term assessments to explore interactions among emotional memory, sleep, and sex differences, with implications for individualized mechanisms underlying post-traumatic stress disorder (PTSD) and its treatments.
The microneme protein1 (MIC1) of Chinese 1 Toxoplasma regulates pyroptosis through the TLR4/NLRP3 pathway in macrophages
Authors: Sun Wenze , Zhang Fan , Zhu Jinjin , Yu Yanxia , Wang Yang , Luo Qingli , Yu Li 
Published: November 2024

Abstract
Background
TgMIC1, a soluble adhesion protein that typically facilitates parasite invasion, exhibited varying expression levels among distinct virulence strains of Chinese 1 Toxoplasma. This study aims to explore its role in immunological regulation and its association with diverse postinfection outcomes in Toxoplasma infection.

Methods
First, the mic1 knockout strain Wh3Δmic1 was generated and assessed for its virulence and proliferative capacity. Subsequently, the serum inflammation levels were examined in mice infected with Wh3Δmic1, Wh3, and Wh6. Furthermore, rMIC1 and rMIC1-T126A/T220A, which lack binding sites to N-glycan in TLR4, were produced for coculture with bone marrow-derived macrophages (BMDMs) to investigate their impact on pyroptosis.

Results
Our data showed Wh3Δmic1 exhibited a significant reduction in invasion efficiency, limited growth, and attenuated inflammatory responses in mice. Additionally, it displayed a decreased capacity to induce pyroptosis when compared with Wh3-infected BMDMs. Moreover, rMIC1 but not rMIC1-T126A/T220A was found to be able to upregulate NOD-like receptor pyrin domain-containing protein 3 (NLRP3) and activate GSDMD and caspase-1 in BMDMs but not in TLR4−/− and NLRP3−/− BMDMs.

Conclusions
TgMIC1 is implicated in both parasite invasion and the modulation of macrophage pyroptosis via the TLR4/NLRP3 pathway. This investigation indicates that TgMIC1 serves diverse functions in Toxoplasma gondii infection, thereby enhancing comprehension of the immune regulatory mechanisms of the parasite.

Graphical Abstract
CULTURAL-PSYCHOLOGICAL APPROACH TO THE STUDY OF RUSSIAN NATIONAL CHARACTER
Authors: Neronova Marina Yu. , Neronov Alexander V. 
Published: November 2024

The article examines the problem of national character research in the humanities from Modern times to the present and analyzes the various approaches used by scientists to solve it. Based on the work carried out, the authors formulate a cultural and psychological approach to the study of national character and apply it to identify and disclose the basic features of the Russian national character
Purpose: to give an idea of the national character as an object of research in the humanities, to conduct a comparative analysis of various approaches to the knowledge of national character, to highlight the cultural and psychological approach and with its help to determine the main features of the Russian national character.
Method and methodology of the work: the method of comparative analysis and the phenomenological method were used.
Results: in the process of analyzing the discourse on national character in the humanities, the authors conclude that the main problem in revealing the phenomenon of national character is related to the subjective nature of the object of study itself, which leads to the emergence of many approaches, each of which is not able to give a complete and exhaustive idea of the object of study. Modern psychology also faces a similar problem in an effort to understand the character of a person. In psychology, an approach was identified that partially managed to overcome this problem. In it, the character is considered through the relationship of a person to various aspects of reality, while the human subject itself is placed "outside the brackets". The authors formulate a cultural and psychological approach combining a psychological approach with a cultural one and using it explore the basic features of the Russian national character.
Scope of the results: The results obtained can be applied in the study of modern social and cultural processes related to national identification and used in the formation of the content of humanitarian courses in higher and secondary education.
A Mathematical Programming Approach for Mongolia’s “The Four Strongest” Puzzle
Authors: Singh Bismark 
Published: November 2024

We describe a mathematical programming approach to solve a recently proposed puzzle from Mongolia. This puzzle involves physically laying out toys of four legendary Mongolian animals in different orientations and positions within a box such that they fit. The author of the puzzle finds a solution by an exhaustive enumeration of the exponentially many possibilities and by employing a series of axiomatic assumptions. In the absence of the physical toys (and, thus, their true measurements), could we use operations research to help us? We present one such approach and several exercises that could be tasked in an introductory course on mathematical optimization. Classroom activities provide us a diverse set of solutions for some of these exercises. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ited.2024.0112 .
Reducing Marketplace Interference Bias via Shadow Prices
Authors: Bright Ido , Delarue Arthur , Lobel Ilan 
Published: November 2024

Marketplace companies rely heavily on experimentation when making changes to the design or operation of their platforms. The workhorse of experimentation is the randomized controlled trial (RCT), or A/B test, in which users are randomly assigned to treatment or control groups. However, marketplace interference causes the stable unit treatment value assumption to be violated, leading to bias in the standard RCT metric. In this work, we propose techniques for platforms to run standard RCTs and still obtain meaningful estimates despite the presence of marketplace interference. We specifically consider a generalized matching setting, in which the platform explicitly matches supply with demand via a linear programming algorithm. Our first proposal is for the platform to estimate the value of global treatment and global control via optimization. We prove that this approach is unbiased in the fluid limit. Our second proposal is to compare the average shadow price of the treatment and control groups rather than the total value accrued by each group. We prove that this technique corresponds to the correct first order approximation (in a Taylor series sense) of the value function of interest even in a finite-size system. We then use this result to prove that, under reasonable assumptions, our estimator is less biased than the RCT estimator. At the heart of our result is the idea that it is relatively easy to model interference in matching-driven marketplaces because, in such markets, the platform mediates the spillover. This paper was accepted by Itai Ashlagi, revenue management and market analytics. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01881 .