bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico production of relative correction factor for the quantitative analysis of multi‐components by single marker method
Authors: Yin Ying‐Hao , Zheng Jia‐Yi , Wang Xin‐Nan , Qian Sheng‐Ying , Liu Xu‐Yi , Liu Li‐Fang , Xin Gui‐Zhong 
Published: July 2019

AbstractIntroductionTraditional methods to derive experimentally‐generated relative correction factors (RCFs) for the quantitative analysis of herbal multi‐components by single marker (QAMS) method require reference standards and multiple validations with different instruments and columns, which hampers high throughput implementation.ObjectivesTo effectively reduce the application amounts of raw material and provide higher and more stable accuracy, this study aimed to develop a method to computationally generate RCFs of herbal components.Materials and MethodsThis strategy included the published data collection, calibration curves screening, computer algorithm‐based RCFs generation and accuracy validation.ResultsUsing the in silico approach, we have successfully produced 133 RCFs for the multi‐component quantitative analysis of 63 widely used herbs.ConclusionCompared with conventional RCFs, this in silico method would be a low cost and highly efficient way to produce practical RCFs for the QAMS method.
Prevalence of Maternal‐Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011‐2015
Authors: Dave Chintan V. , Goodin Amie , Zhu Yanmin , Winterstein Almut , Wang Xi , Alrwisan Adel , Hartzema Abraham 
Published: July 2019

BackgroundDespite the rising incidence of neonatal abstinence syndrome (NAS), data evaluating trends in maternal risk factors associated with NAS have not been available for recent years, a period characterized by declining opioid prescriptions. The objective of this study was to examine the prevalence of opioid‐ and non–opioid‐related factors associated with NAS, and by mutually exclusive subgroups of deliveries without prescription‐opioid use, with prescription‐opioid use, and with opioid‐use disorder (OUD).MethodsA cohort of pregnancies resulting in live births in a commercial claims data base in 2011–2015 was identified. Examples of maternal risk factors of interest included antepartum prescription‐drug use (e.g., opioids, selective serotonin reuptake inhibitors [SSRIs], antipsychotics) and nonprescription‐related factors (e.g., smoking, OUD).ResultsA total of 659 cases of NAS among 621,940 deliveries was identified. Among NAS deliveries, prescription opioids were the most commonly used drug‐class (39.0%). Adjusted relative risk (RR) for NAS was 5.43 (95% confidence interval [CI] 4.25–6.95), followed by SSRIs (20.9%; RR 3.16, CI 2.43–4.11); OUD was noted in 36.3% of the deliveries (RR 40.74, CI 22.64–73.32). In the subgroup of deliveries without a prescription opioid (33% of overall NAS deliveries), the absolute incidence of NAS was low (0.3 cases/1000 deliveries), and SSRIs were the most commonly used medication class (32.7%; RR 10.21, CI 7.28–14.31). In the subgroup of deliveries with an opioid prescription, the absolute incidence of NAS was 7.7/1000 (29% of all overall NAS deliveries), and 22.7% of these deliveries were exposed to one other psychotropic agent in addition to the opioid, most commonly an SSRI (18.0%). In the subgroup of deliveries with a diagnosis of OUD, the NAS incidence was high (214.3/1000 [36% of all NAS cases]).ConclusionA third of NAS deliveries did not have evidence of prescription opioids. Other psychotropic medications, especially SSRIs, were strong predictors of NAS in this stratum but had no relevance among deliveries with OUD, suggesting varying etiologies and the need for tailored preventive approaches to reduce NAS effectively.
Temperature‐dependent transition of crystal phases in the electrospinning process of poly(vinylidene fluoride‐co‐hexafluoropropylene)
Authors: Jung Dae Eon , Lee Ki Hyun , Lee Eun Jeoung , Kim Byoung Chul 
Published: July 2019

AbstractThe temperature‐dependent transition of the crystal phases of poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP) was investigated in the electrospinning process. A solution of PVDF‐HFP in N,N‐dimethyl acetamide (DMAc) produced only the β‐phase‐dominant crystal up to 70 °C, irrespective of the spinneret temperature. In a mixed solvent of DMAc and acetone, however, the crystal phase of the electrospun fibers was dependent on temperature: β‐phase‐dominant at 30 and 50 °C and α‐phase‐dominant at 70 °C. The transition was related to a change of the coagulation rate during electrospinning, because the less perfect α phase is preferable to the β phase at a higher coagulation rate. The temperature‐dependent increase of the coagulation rate was more drastic in the presence of acetone, so the transition took place only in the mixed solvent. At elevated temperature, acetone not only raised the evaporation rate of the solvent but promoted the phase separation of the polymer resulting from the lower critical solution temperature behavior, which was rheologically traced. © 2019 Society of Chemical Industry
Mechanical Properties of Muscles around the Shoulder in Breast Cancer Patients: Intra‐rater and Inter‐rater Reliability of the MyotonPRO
Authors: Yeo Seung Mi , Kang Hyojeong , An Soyeon , Cheong Inyae , Kim Yoon , Hwang Ji Hye 
Published: July 2019

BackgroundPatients with breast cancer typically experience changes in the properties of muscles around the shoulder. However, there is no appropriate evaluation tool for these changes.ObjectiveThe primary objective was to investigate the inter‐rater and intra‐rater reliability of muscle‐related parameters measured by the MyotonPRO, a myotonometer device. The secondary objective was to investigate differences in properties of muscle around the shoulder between the mastectomy side and the other side.DesignCross‐sectional reliability study.SettingOutpatient clinic in a tertiary care university‐affiliated hospital.ParticipantsTwenty‐two patients with breast cancer who underwent mastectomy.MethodsMuscle tone, stiffness, and elasticity of the pectoralis major (PM), sternocleidomastoid (SCM), and upper trapezius (UT) were measured using the MyotonPRO. Rater 1 performed two sets of measurements with a time interval of 30 minutes to determine intra‐rater reliability. Rater 2 performed measurements during the interval between the two sets of rater 1. Reliability was assessed using intraclass correlation coefficients (ICCs) and Bland‐Altman analysis. A paired t‐test was used to compare muscle properties between the affected and unaffected sides.Main Outcome MeasurementsFrequency (tone, Hz), stiffness (N/m), and decrement (elasticity).ResultsIntra‐rater reliability was excellent (ICC > 0.75, 0.85‐0.98) for all parameters of the PM, SCM, and UT in the affected and unaffected upper limbs of patients with breast cancer. Inter‐rater reliability was fair to excellent for all parameters except unaffected PM elasticity (ICC = 0.34). There were significant differences in all parameters of the PM between the affected and unaffected sides. There were no significant differences in the parameters of the SCM and UT between the two sides.ConclusionsOur findings indicate that the MyotonPRO device is a feasible tool to quantify PM, UT, and SCM muscle properties (stiffness, tone, and elasticity) in patients with breast cancer.Level of EvidenceIII.
Janus Multicolored Photonic Crystal Beads for Real‐Time Magnetic Responsive Patterns
Authors: Huang Chao , Cheng Yu , Zhang Hanbing , Wei Jie 
Published: July 2019

AbstractPhotonic Janus particles that can change colors in different stimuli have shown great promise in various applications, such as optical probes, catalyst supports, sensors, and display materials. However, it remains a challenge to produce Janus structural colored particles with a simple method. Inspired from ecsenius bicolors, a facile preparation of Janus structural colored beads (JSCBs) using sub‐micrometer‐sized colloidal particles and magnetic nanoparticles composed of Fe3O4 is established. A mixed emulsion is prepared by monodispersed colloidal particles and magnetic nanoparticles and initiator of PDMS precursor. Subsequent self‐assembly of the emulsion in the room temperature environment provides two different structural colors, thanks to the gravity deposition of colloidal particles and Fe3O4 nanoparticles. The photonic bandgap of JSCBs can be precisely controlled with varying size of monodispersed colloidal nanoparticles, and the high optical quality and mechanical strength of the structural colored face are attributed to the existence of PDMS. In the presence of a magnet, the JSCBs can change their orientation simultaneously between two different structural colors. Moreover, the JSCBs are capable of encoding and angle‐independent displaying, which are crucial to their applications in anticounterfeiting, information coding, and pattern display.
An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis
Authors: Keown Karen , Abbott Salome , Kuzeljevic Boris , Rayment Jonathan H. , Chilvers Mark A. , Yang Connie L. 
Published: July 2019

AbstractBackgroundAllergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to Aspergillus fumigatus (Af) which occurs in 10% of patients with cystic fibrosis (CF). ABPA is associated with increased morbidity and accelerated lung function decline; however, existing diagnostic criteria are nonspecific and diagnosis remains challenging. As ABPA is driven by Th2 inflammation, the aim of this study was to evaluate exhaled nitric oxide (FE
NO), eosinophilic cationic protein (ECP), peripheral eosinophil count, and bronchodilator response (BDR) in patients with CF.MethodsA prospective observational cohort study of pediatric CF patients in a tertiary center. Patients had a clinical and serologic ABPA assessment, FENO, serum ECP, peripheral eosinophil count, and assessment of BDR. Patients were stratified into three groups; ABPA, Af sensitized (AFS), and non‐ABPA non‐Af‐sensitized (non‐AFS).ResultsA total of 62 patients were included in the study: 13% ABPA, 19% AFS, and 68% non‐AFS. Mean FENO was higher in the ABPA group at 37.8 ppb compared to AFS 15.1 ppb (P = .05) and non‐AFS 13.7 ppb (P = .04). Mean peripheral eosinophil count in ABPA group was also higher at 1000 cells/uL, compared to AFS 221 cells/uL (P = .03) and non‐AFS 220 cells/uL (P = .03). Mean BDR in ABPA group was 13% compared to 5.5% in non‐AFS (P = .01). Serum ECP was higher in patients with ABPA positive compared to the other groups, although this was not statistically significant.ConclusionIn children with cystic fibrosis, FENO and peripheral eosinophil counts are elevated in ABPA compared to those that are just sensitized to Aspergillus and may serve as useful diagnostic tests.
Reliability technology using GO methodology: A review
Authors: Yi Xiao‐jian , Shi Jian , Cheng Jun 
Published: July 2019

AbstractGoal‐oriented (GO) methodology is a graphic inductive method mapping the system structure, its function constitute, characteristics, and working principle visually based on decision tree. Recently, the studies on reliability technologies for GO method of complex systems have been gotten a lot of attention by scholars because of the obvious advantages of modeling and analysis power. Indeed, the GO method has been applied in reliability and safety analysis of various areas, such as transportation and power systems, to prove its value. Thus, this paper provides a brief review of the GO method from aspects of providing its development history and its engineering applications and expounding its development of the theory of the GO method. At last, the future directions of GO method are discussed.
The Role of Goldschmidt’s Tolerance Factor in the Formation of A2BX6 Double Halide Perovskites and its Optimal Range
Authors: Fedorovskiy Alexander E. , Drigo Nikita A. , Nazeeruddin Mohammad Khaja 
Published: July 2019

AbstractVacancy‐ordered double perovskites is a new branch of lead‐free halide perovskites with properties promising for photovoltaic application. In this study, data about the crystal structure of 170 known A2BX6 (X = I, Br, Cl, F) are collected and analyzed to solve a question of applicability of the Goldschmidt’s tolerance factor and octahedral factor to double perovskites. It is found that Goldschmidt’s tolerance factor is applicable for double perovskites in analog with ABX3 perovskites. Suggested optimal ranges of Goldschmidt’s factor expand the geometrical approach from ABX3 perovskites to A2BX6 double perovskites. The result is useful for up to 796 new full inorganic compounds having double‐perovskite structure and designing new hybrid organic–inorganic double perovskites.
Colonial Waterbird Predation and Angler Catch of Hatchery Rainbow Trout Stocked in Southern Idaho Fisheries
Authors: Chiaramonte Luciano V. , Meyer Kevin A. , Lamansky James A. 
Published: July 2019

AbstractThe abundance of piscivorous colonial waterbirds such as double‐crested cormorants Phalacrocorax auritus and American white pelicans Pelecanus erythrorhynchos has increased dramatically in recent decades in North America, resulting in increased conflict between these birds and fisheries resources, which raises the need to quantify the effects of waterbird predation on fisheries. We estimated avian predation and angler use of two sizes of hatchery‐reared Rainbow Trout Oncorhynchus mykiss (250 mm and 300 mm on average; termed standard catchables and magnum catchables) at 15 Idaho waters with known cormorant and pelican presence. Fish were tagged with passive integrated transponder (PIT), radio, and T‐bar anchor tags prior to release; the tags were subsequently recovered from bird nesting, roosting, and loafing sites. Estimated angler use, which included fish harvested as well as those that were catch‐and‐release, averaged 17%, while avian predation averaged 35%. Angler catch at study waters declined exponentially as avian predation increased. Predation specifically attributed to double‐crested cormorants and American white pelicans was related to their relative abundance at the waterbodies where the fish were stocked. Avian predation rates were similar for standard and magnum catchables, suggesting that larger fish were not able to escape predation any better than smaller ones. Our results add to existing evidence indicating that in some southern Idaho fisheries, piscivorous birds, rather than anglers, are the dominant consumers of hatchery trout. This study further contributes to the larger issue of competition between humans, wildlife, and fisheries populations.
Examining Life History Shifts and Genetic Composition in a Hatchery Steelhead Population, with Implications for Fishery and Ocean Selection
Authors: Bowersox Brett J. , Corsi Matthew P. , McCormick Joshua L. , Copeland Timothy , Campbell Matthew R. 
Published: July 2019

AbstractSteelhead Oncorhynchus mykiss exhibit significant variation in life histories. Dworshak National Fish Hatchery (NFH)‐stock steelhead exhibit a life history that is unique compared to other Columbia River basin hatchery summer steelhead stocks, as it is dominated by older and larger‐length fish relative to conspecifics. We evaluated changes within the Dworshak NFH stock's ocean age composition and length at age from run years 1978 to 2016 using samples collected from the commercial gill‐net fishery, the sport fishery, and the hatchery trap. In addition, we analyzed the genetic composition of the stock by comparing samples collected in 1969 from the wild founding stock to samples from recent returns. We found that Dworshak NFH steelhead became younger across the study, with fewer of the oldest, three‐ocean fish (i.e., rearing in the ocean for 3 years) and increases in the proportion of the population returning as one‐ocean fish (i.e., rearing in the ocean for 1 year). Length at ocean age decreased for all ocean ages; however, the decrease was not significant in one‐ocean fish. In general, samples collected from gill nets and the sport fishery contained fish with older ocean ages and larger sizes at age compared to samples collected from the hatchery trap. Neutral genetic diversity, as measured from a panel of single‐nucleotide polymorphic markers, showed no changes between the sample of fish representing the original founders and the present‐day population. Life history shifts observed in Dworshak NFH‐stock steelhead were likely influenced by a variety of factors, including gear selectivity and changing ocean conditions. Decreases in ocean age composition and length at age have implications for both fishery and broodstock management as well as generating concern that similar trends may be occurring within wild steelhead stocks.
Systematic analysis of copy‐number variations associated with early pregnancy loss
Authors: Wang Y. , Li Y. , Chen Y. , Zhou R. , Sang Z. , Meng L. , Tan J. , Qiao F. , Bao Q. , Luo D. , Peng C. , Wang Y. S. , Luo C. , Hu P. , Xu Z. 
Published: July 2019

ABSTRACTObjectivesEmbryonic numerical and structural chromosomal abnormalities are the most common cause of early pregnancy loss. However, the role of submicroscopic copy‐number variations (CNVs) in early pregnancy loss is unclear, and little is known about the critical regions and candidate genes for miscarriage, because of the large size of structural chromosomal abnormalities. The aim of this study was to identify potential miscarriage‐associated submicroscopic CNVs and critical regions of large CNVs as well as candidate genes for miscarriage.MethodsOver a 5‐year period, 5180 fresh miscarriage specimens were investigated using quantitative fluorescent polymerase chain reaction/CNV sequencing or chromosomal microarray analysis. Statistically significant submicroscopic CNVs were identified by comparing the frequency of recurrent submicroscopic CNVs between cases and a published control cohort. Furthermore, genes within critical regions of miscarriage‐associated CNVs were prioritized by integrating the Residual Variation Intolerance Score and the human gene expression dataset for identification of potential miscarriage candidate genes.ResultsResults without significant maternal‐cell contamination were obtained in 5003 of the 5180 (96.6%) cases. Clinically significant chromosomal abnormalities were identified in 59.1% (2955/5003) of these cases. Three recurrent submicroscopic CNVs (microdeletions in 22q11.21, 2q37.3 and 9p24.3p24.2) were significantly more frequent in miscarriage cases, and were considered to be associated with miscarriage. Moreover, 44 critical regions of large CNVs were observed, including 14 deletions and 30 duplications. There were 309 genes identified as potential miscarriage candidate genes through gene‐prioritization analysis.ConclusionsWe identified potential miscarriage candidate CNVs and genes. These data demonstrate the importance of CNVs in the etiology of miscarriage and highlight the importance of ongoing analysis of CNVs in the study of miscarriage. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Performance of different fetal growth charts in prediction of large‐for‐gestational age and associated neonatal morbidity in multiethnic obese population
Authors: Verger C. , Moraitis A. A. , Barnfield L. , Sovio U. , Bamfo J. E. A. K. 
Published: July 2019

ABSTRACTObjectivesTo examine the performance of different fetal growth charts in the prediction of large‐for‐gestational age (LGA) and associated neonatal morbidity at term in a multiethnic, obese population.MethodsThis was a retrospective cohort study of 253 non‐anomalous, singleton, term pregnancies that underwent serial third‐trimester ultrasound scans due to maternal body mass index ≥ 35 kg/m2. We compared the performance of the Hadlock, Gestation Related Optimal Weight (GROW), INTERGROWTH‐21st (IG‐21), World Health Organization (WHO) and Fetal Medicine Foundation (FMF) fetal growth reference charts in the prediction of LGA at birth, defined as birth weight > 90th percentile, and neonatal morbidity, defined as a composite of neonatal intensive care unit admission or 5‐min Apgar score < 7.ResultsIn the study population, 53 (20.9%) infants were born LGA, 27 (10.7%) experienced neonatal morbidity and nine (3.6%) were LGA with associated neonatal morbidity. The Hadlock and GROW charts showed similar performance in predicting LGA, with sensitivity of 66.0% for both and specificity of 82.5% and 83.5%, respectively. The positive likelihood ratios (LR+) were 3.77 (95% CI, 2.64–5.40) and 4.00 (95% CI, 2.77–5.78), respectively. The IG‐21, WHO and FMF charts performed similarly and had higher sensitivity of about 85%, with specificity between 66% and 72%. LR+ was 2.74 (95% CI, 2.16–3.47), 2.50 (95% CI, 2.00–3.12) and 3.03 (95% CI, 2.36–3.89), respectively. All charts had high sensitivity for predicting neonatal morbidity associated with LGA, with LR+ ranging between 2.35 and 3.61.ConclusionsIn our multiethnic, obese population, all fetal growth charts performed well in predicting LGA and associated neonatal morbidity. However, the choice of fetal reference chart is likely to affect intervention rates. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Fat mass compared to four body condition scoring systems in the Asian elephant (Elephas maximus)
Authors: Chusyd Daniella E. , Brown Janine L. , Golzarri‐Arroyo Lilian , Dickinson Stephanie L. , Johnson Maria S. , Allison David B. , Nagy Tim R. 
Published: July 2019

AbstractCaptive elephant populations are not self‐sustaining due to health concerns possibly related to obesity. Categorizing obesity relies on qualitative analyses like body condition scores (BCS). However, elephant indices have not been validated against measured body composition. The objective was to compare BCS systems to body composition determined by deuterium dilution in 28 zoo‐kept Asian elephants. Elephants were weighed and given deuterated water orally (0.05 ml/kg). Blood was collected at ~0, 24, 120, 240, 360, and 480 hr after dosing. Photographs were taken to score the elephant based on four BCS systems (BCSWemmer[0 to 11 scoring], BCSMorfeld[1 to 5 scoring], BCSFernando[0 to 10 scoring], BCSWijeyamohan[1 to 10 scoring]). Based on regression analysis, relative fat ranged from −305 kg to 515 kg, where negative values indicate less and positive values indicate more fat than expected for the elephant's mass in this population. BCSFernandowas associated with relative fat (p = .020,R2 = 0.194). Relative fat, adjusted for sex and age in the statistical model, was associated with BCSWemmer(p = .027,R2 = 0.389), BCSFernando(p = .002,R2 = 0.502), and BCSWijeyamohan(p = .011,R2 = 0.426). Inclusion of zoo and familial relatedness resulted in all BCS systems associated with relative fat (p ≤ .015). Only BCSFernandopredicted relative fat, unadjusted, suggesting it is the most capable system for practical use. Compared to absolute fat, relative fat may be more biologically relevant as greater fat relative to body mass is more likely to lead to health issues.