bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial materials based on photothermal action and their application in wound treatment
Authors: Cao Jiangli , Song Zhiyong , Du Ting , Du Xinjun 
Published: December 2024

Abstract
Considering the increasing abundance of antibiotic-resistant bacteria, novel antimicrobial approaches need to be investigated. Photothermal therapy (PTT), an innovative noninvasive therapeutic technique, has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms. However, when used in isolation, PTT requires higher-temperature conditions to effectively eradicate bacteria, thereby potentially harming healthy tissues and inducing new inflammation. This study aims to present a comprehensive review of nanomaterials with intrinsic antimicrobial properties, antimicrobial materials relying on photothermal action, and nanomaterials using drug delivery antimicrobial action, along with their applications in antimicrobials. Additionally, the synergistic mechanisms of these antimicrobial approaches are elucidated. The review provides a reference for developing multifunctional photothermal nanoplatforms for treating bacterially infected wounds.
Modeling, control study, and power management strategy of a hybrid grid-connected AC/DC microgrid with high integration of renewable energies and green hydrogen sources
Authors: El Qouarti Ouassima , Nasser Tamou , Essadki Ahmed , Aboudrar Imad , Nadour Mohamed 
Published: December 2024

Abstract
This first quarter of the 21st century is increasingly marked by population growth, digital and industrial developments, a growing need for electricity supply, and climate change. All these, to name just a few, have made the establishment of a stable, flexible, controlled, well-designed, extensive, and clean power system a necessity. Consequently, distributed microgrid generation based on alternative/renewable energies and/or low-carbon technologies has emerged. In this paper, we study the modeling, the control, and the power management strategy of a grid-connected hybrid alternating/direct current (AC/DC) microgrid based on a wind turbine generation system using a doubly fed induction generator, a photovoltaic generation system, and storage elements including hydrogen storage system and batteries. Adequate modeling is described, and the overall system monitoring is presented and applied to manage appropriate power sharing and to control active and reactive powers, in order to match load and weather fluctuation behavior. Simulations are carried out using a MATLAB/Simulink simulation tool. Simulations reveal convenient results in terms of the bidirectional interlinking converter capabilities regarding power balance establishment between the two subgrids, reactive power compensation to ensure a unity power factor, and DC-bus voltage regulation at 1200 V. In addition, the primary and secondary controls are approved for each distributed generation of the studied system to attain the assigned power references, regardless of whether the subgrid is heavily or lightly loaded throughout the four considered case studies, showing satisfactory tracking and interacting performances, and thus stimulating a stable system implementation.
Opportunities and challenges of large-scale salt cavern hydrogen storage in China coupled with renewable energy sources
Authors: Bai Weizheng , Shi Xilin , Zhu Shijie , Wei Xinxing , Huang Yashuai 
Published: December 2024

Abstract
To expedite China’s pursuit of the “dual-carbon” goal, a gradual transition from traditional fossil energy to renewable energy sources is imperative for the nation’s energy mix. Hydrogen energy, poised to become a pivotal component of the future energy industry, offers myriad advantages, including diverse sources, high efficiency, cleanliness, and high energy density. Salt caverns present distinct benefits for underground storage. This research synthesizes the current development trajectories of renewable energy and hydrogen energy in China, summarizing the advantages, disadvantages, and economic comparisons of various underground hydrogen storage methods, with a particular emphasis on the merits of salt cavern hydrogen storage. Furthermore, it reviews the current state and opportunities for salt cavern hydrogen storage both domestically and internationally, underscoring its substantial potential within China. Ultimately, the research identifies three major scientific and technological challenges associated with hydrogen storage in salt caverns in China and envisions future directions for this technology. The findings of this research are anticipated to contribute to the development of a hydrogen storage strategy in salt caverns that aligns with China’s national conditions.
Catalytic degradation of nitrobenzene derivatives by platinum nanoparticles stabilized in diblock spherical polymer brushes
Authors: Xu Chenming , Hua Chen , Chen Kaimin , Li Ziwei , Yu Liang , Zhang Xueke , Chang Yue 
Published: December 2024

Abstract
A new type of core–shell diblock spherical polymer brushes, poly 2-(methacryloyloxy)ethyl-trimethylammonium chloride-b-poly(N-isopropylacrylamide) diblock polymer brushes with polystyrene cores (PSV@PMETAC-b-PNIPA), was prepared through a surface-initiated photoiniferter-mediated polymerization method. The PSV@PMETAC-b-PNIPA (DSPB) was further used as the nanoreactor to prepare and stabilize platinum nanoparticles in situ (DSPB@Pt). By controlling the reaction temperature, substances with similar structure but different hydrophilicity, i.e. 4-nitrophenol and nitrobenzene, could be catalyzed by DSPB@Pt with different catalytic behaviors.
How citizen science helps to expand the distribution and describe predictors related to a native land snail, while also introducing spatial biases
Authors: Barahona-Segovia Rodrigo M , Gómez Persy , Céspedes-Parada Belén , Soto-Silva Constanza , González-Tobar Matías , Olea-Hernández Christopher , Alfaro Elías 
Published: December 2024

Abstract
Although mollusks represent Earth’s second most diverse invertebrate group, their natural history and ecology are still scarcely known. The compilation of non-traditional data, such as those from citizen science, represents an alternative to fill these gaps, particularly on striking land snail species such as Macrocyclis peruvianus. Based on long-term citizen science, we aimed to update and describe some basic ecological aspects, such as the distribution and protected area types used by M. peruvianus. We performed pairwise comparisons to test potential changes in occurrence and occupancy among administrative regions, forest types, and protected area types using chi-squared tests. The citizen scientists were also asked to provide the number of M. peruvianus individuals observed and the tree species that dominated their habitat. Thus, we tested if the number of land snails found by citizen scientists could be related to forest and protected area types using a generalized linear mixed model. We expanded the northern distributional limit, with Nothofagus, evergreen, and mixed forests far the most frequented by M. peruvianus. Parallelly, the occurrence of M. peruvianus in official protected areas (65.73%) was significantly higher than in privately owned areas. Moreover, we did not find associations between forest and protected area types with the number of M. peruvianus recorded. Although citizen science is a helpful method for obtaining novel information regarding the ecology of neglected species such as M. peruvianus, it also introduces spatial and occurrence biases explained by the access and attractiveness of the officially protected areas compared to privately owned patches of native forest.
Antithrombotic therapy in patients with chronic coronary syndrome: a focus on the 2024 European Society of Cardiology guidelines
Authors: Landi Antonio , Valgimigli Marco 
Published: December 2024

Abstract
Antithrombotic therapy represents the mainstay of the pharmacological treatment in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). The optimal choice, combination, and duration of antithrombotic therapy represent still a clinical conundrum requiring a critical assessment of patient comorbidities, clinical presentation, and PCI features. The 2024 European Society of Cardiology (ESC) guidelines for the management of patients with CCS have been recently published encompassing new and revised recommendations on antithrombotic therapy. The scope of this manuscript is to provide a focus on the key recommendations on antithrombotic therapy of the 2024 ESC guidelines. Furthermore, we will provide an overview of differences and similarities between the latest ESC recommendations and statements on oral antithrombotic regimens in CCS patients from a recent European expert consensus document.
Neurohormonal response is associated with mortality in women with ST-elevation myocardial infarction
Authors: Kunkel Joakim Bo , Søholm Helle , Holle Sarah L D , Goetze Jens P , Holmvang Lene , Jensen Lisette O , Sheikh Annam P , Møller Jacob E , Hassager Christian , Frydland Martin 
Published: December 2024

Abstract

Aims
Women continue to have a worse prognosis following ST-elevation myocardial infarction (STEMI) compared to men, despite advancements in treatment. This study investigates whether neurohormonal biomarker differences contribute to sex-related disparities in mortality.

Methods and results
A total of 1892 consecutive STEMI patients from two tertiary heart centres were included. Admission neurohormonal activation defined as pro-atrial natriuretic peptide (proANP) and mid-regional pro-adrenomedullin (MR-proADM) was measured in blood drawn prior to acute coronary angiography (CAG). The primary endpoint was 1-year mortality stratified according to sex and biomarker level. Of 1782 (94%) with biomarkers available, 476 (27%) of patients were women. They were older (68 vs. 62 years), had longer symptom-to-angiography delay (211 vs. 181 min), and displayed a higher one-year mortality rate (12% vs. 7.4%, P &lt; 0.001) compared to men. The neurohormonal response was higher in women compared to men [median (interquartile range) proANP 1050 (671–1591) vs. 772 (492–1294) pmol/L, P &lt; 0.001); MR-proADM 0.80 (0.63–1.03) vs. 0.70 (0.58–0.89) nmol/L, P &lt; 0.001]. In women, a level at or above the median was independently associated with a significantly higher mortality risk when adjusting for age, left ventricular ejection fraction, diabetes, heart failure, symptom onset to CAG, left-sided culprit lesion, obesity, renal dysfunction, primary percutaneous intervention, admission systolic blood pressure, and multivessel disease (HR proANP 6.05, 95% CI 1.81–20.3, P = 0.004; HR MR-proADM 3.49, 95% CI 1.42–8.62, P = 0.007). In men, there was an independent prognostic association for proANP but not for MR-proADM (HR proANP 2.38, 95% CI 1.18–4.81, P = 0.015; HR MR-proADM 1.74, 95% CI 0.89–3.40, P = 0.11).

Conclusion
Increased neurohormonal activation (MR-proADM and proANP) is associated with higher mortality in women compared to men. Neurohormonal activation may contribute to the observed sex-related differences in mortality.
Usefulness of dynamic perfusion SPECT with quantitative assessment of myocardial perfusion reserve for the detection of myocardial ischaemia in patients with presumed new left bundle branch block
Authors: Manrique Alain , Guery Clément , Legallois Damien , Richard Pascal , Roule Vincent , Agostini Denis 
Published: December 2024

Abstract

Aims
The aim of this retrospective study was to evaluate the ability of dynamic SPECT with quantitative analysis of myocardial blood flow (MBF) and myocardial flow reserve (MFR) for the detection of coronary artery disease (CAD) in patients with presumed new left bundle branch block (LBBB).

Methods and results
We evaluated the dynamic SPECT results from 174 consecutive patients with LBBB without a history of CAD from a single center. MBF was assessed at rest and during regadenoson (400 μg). Normal MFR was defined as ≥ 2.1. Left ventricular function and segmental perfusion were assessed from conventional gated SPECT. SPECT abnormalities were found in 17/174 (10%) patients including a reversible SPECT defect in 4 patients (2.3%), a fixed defect in 12 patients (7%), and both in 1 patient. Global left ventricular function was normal despite a significant impairment of septal wall motion. Stress and rest MBF was decreased in the septum and the inferior wall compared with other walls (P &lt; 0.0001), resulting in similar MFR. A reduced MFR was associated with a fixed defect (P = 0.04). Only 18 patients (10%) presented with a decreased MFR. They were more often referred to subsequent coronary angiography (8/18, 44%) compared with patients with a normal MFR (9/156, 6%, χ2 = 27.382, P &lt; 0.0001). However, significant coronary lesions were finally found in only 4/174 patients (2%).

Conclusion
Although a decreased MFR was associated with a fixed defect on conventional perfusion imaging, the low rate of CAD finally demonstrated in this study questions the relevance of routine screening for CAD in patients with presumed new LBBB.
The evolution and genetic basis of a functionally critical skull bone, the parasphenoid, among Lake Malawi cichlids
Authors: Conith Andrew J , Pascarella Sarah M , Hope Sylvie A , Albertson R Craig 
Published: December 2024

Abstract
Adaptive radiation, whereby a clade pairs rapid speciation with rapid phenotypic evolution, can result in an uneven distribution of biodiversity across the Metazoan tree. The cichlid fishes of East Africa have undergone multiple adaptive radiations within the major rift lakes. Cichlid radiations are marked by divergence across distinct habitat gradients producing many morphological and behavioural adaptations. Here, we characterize the shape of the parasphenoid, a bone in the neurocranium that dissipates forces generated during feeding. We examine Tropheops, a group that has transitioned between deep and shallow habitats multiple times, to examine habitat-specific differences in parasphenoid shape. We find differences in the depth and length of the parasphenoid between Tropheops residing in each habitat, variation that may impact the ability of the cranium to resist force. We next use a hybrid cross between two cichlid species that differ in parasphenoid shape, Labeotropheus and Tropheops, to examine the genetic basis of these morphological differences. We perform genetic mapping and identify two genomic regions responsible for variation in parasphenoid shape. These regions are implicated in other functional traits including the oral jaws and neurocranium, indicating that the genetic landscape for adaptive evolution may be limited to a few loci with broad effects. Repurposing the same gene(s) for multiple traits via regulatory evolution may be sufficient for selection to drive transitions between habitats important for incipient stages of adaptive radiations.
Contact zones reveal restricted introgression despite frequent hybridization across a recent lizard radiation
Authors: Zozaya Stephen M , Macor Scott A , Schembri Rhiannon , Higgie Megan , Hoskin Conrad J , O’Hara Kate , Lau Ching Ching , Read Wesley J , Moritz Craig 
Published: December 2024

Abstract
Introgression—the exchange of genetic material through hybridization—is now recognized as common among animal species. The extent of introgression, however, can vary considerably even when it occurs: for example, introgression can be geographically restricted or so pervasive that populations merge. Such variation highlights the importance of understanding the factors mediating introgression. Here we used genome-wide SNP data to assess hybridization and introgression at 32 contact zones, comprising 21 phylogenetic independent contrasts across a recent lizard radiation (Heteronotia). We then tested the relationship between the extent of introgression (average admixture at contact zones) and genomic divergence across independent contrasts. Early-generation hybrids were detected at contact zones spanning the range of genomic divergence included here. Despite this, we found that introgression is remarkably rare and, when observed, geographically restricted. Only the two most genomically similar population pairs showed introgression beyond 5 km of the contact zone. Introgression dropped precipitously at only modest levels of genomic divergence, beyond which it was absent or extremely low. Our results contrast with the growing number of studies indicating that introgression is prevalent among animals, suggesting that animal groups will vary considerably in their propensity for introgression.
The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance
Authors: Abou-Kandil Ammar , Tröger-Görler Sophie , Pschibul Annica , Krüger Thomas , Rosin Maira , Schmidt Franziska , Akbarimoghaddam Parastoo , Sarkar Arjun , Cseresnyés Zoltán , Shadkchan Yana , Heinekamp Thorsten , Gräler Markus H , Barber Amelia E , Walther Grit , Figge Marc Thilo , Brakhage Axel A , Osherov Nir , Kniemeyer Olaf 
Published: December 2024

Abstract
The polyene antimycotic amphotericin B (AmB) and its liposomal formulation AmBisome belong to the treatment options of invasive aspergillosis caused by Aspergillus fumigatus. Increasing resistance to AmB in clinical isolates of Aspergillus species is a growing concern, but mechanisms of AmB resistance remain unclear. In this study, we conducted a proteomic analysis of A. fumigatus exposed to sublethal concentrations of AmB and AmBisome. Both antifungals induced significantly increased levels of proteins involved in aromatic acid metabolism, transmembrane transport, and secondary metabolite biosynthesis. One of the most upregulated proteins was RtaA, a member of the RTA-like protein family, which includes conserved fungal membrane proteins with putative functions as transporters or translocases. Accordingly, we found that RtaA is mainly located in the cytoplasmic membrane and to a minor extent in vacuolar-like structures. Deletion of rtaA led to increased polyene sensitivity and its overexpression resulted in modest resistance. Interestingly, rtaA expression was only induced by exposure to the polyenes AmB and nystatin, but not by itraconazole and caspofungin. Orthologues of rtaA were also induced by AmB exposure in A. lentulus and A. terreus. Deletion of rtaA did not significantly change the ergosterol content of A. fumigatus, but decreased fluorescence intensity of the sterol-binding stain filipin. This suggests that RtaA is involved in sterol and lipid trafficking, possibly by transporting the target ergosterol to or from lipid droplets. These findings reveal the contribution of RtaA to polyene resistance in A. fumigatus, and thus provide a new putative target for antifungal drug development.
State drug caps associated with fewer Medicaid-covered prescriptions for opioid use disorder, 2017-2022
Authors: Besaw Robert J , Fry Carrie E 
Published: December 2024

Abstract
The Medicaid program is the largest payer of opioid use disorder (OUD) treatment, including medications for OUD (MOUD). Because of budget neutrality requirements, some Medicaid programs use prescription drug caps to limit the monthly number of prescriptions an enrollee can fill. This study examined the association between Medicaid prescription drug caps and Medicaid-covered prescriptions for 2 forms of MOUD (buprenorphine and naltrexone) from 2017 to 2022 using fee-for-service and managed care data from Medicaid's State Drug Utilization Data. Ten states had monthly prescription drug caps, ranging from 3 to 6 prescriptions. Using multivariate linear regression, we estimated that enrollees in states with monthly drug caps filled 1489.3 fewer MOUD prescriptions per 100 000 enrollees. Further, compared with states with the smallest drug caps (3 drugs), enrollees in states with 4-, 5-, and 6-drug caps filled significantly more prescriptions per state-quarter (907.7, 562.6, and 438.9 more prescriptions, respectively). Our results were robust to sensitivity analyses. Monthly prescription drug caps were significantly associated with a reduction in Medicaid-covered MOUD prescriptions. Medicaid enrollees who need MOUD may be affected by indiscriminate prescription drug cap policies, potentially hindering ongoing efforts to mitigate the opioid crisis.
Deactivating mutations in the catalytic site of a companion serine carboxypeptidase-like acyltransferase enhance catechin galloylation in Camellia plants
Authors: Chen Xiangxiang , Zhang Xue , Zhao Yue , Gao Liping , Wang Zhihui , Su Yanlei , Zhang Lingyun , Xia Tao , Liu Yajun 
Published: December 2024

Abstract
Galloylated flavan-3-ols are key quality and health-related compounds in tea plants of Camellia section Thea. Camellia ptilophylla and Camellia sinensis are two representative species known for their high levels of galloylated flavan-3-ols. Building on our knowledge of galloyl catechin biosynthesis in C. sinensis, we now focus on the biosynthesis of galloylated phenolics in C. ptilophylla, aiming to elucidate the mechanisms underlying the high accumulation of these compounds in Camellia species. The phenolic compounds in C. ptilophylla were identified and quantified using chromatographic and colorimetric methods. Genes involved in polyphenol galloylation were identified by correlating gene expression with the accumulation of galloylated phenolics across 18 additional Camellia species and 1 related species using Weighted Gene Co-expression Network Analysis. Key findings include the co-expression of SCPL4/2 and SCPL5 subgroup enzymes as crucial for galloylation of catechins, while SCPL3 and SCPL8 showed enzymatic activity related to hydrolyzable tannin synthesis. Variations in the amino acid sequences of SCPL5, particularly in the catalytic triad (T-D-Y vs. S-D-H) observed in C. ptilophylla and C. sinensis, were found to significantly affect enzymatic activity and EGCG production. In conclusion, this research provides important insights into the metabolic pathways of C. ptilophylla, emphasizing the critical role of SCPL enzymes in shaping the phenolic profile within the section Thea. The findings have significant implications for the cultivation and breeding of tea plants with optimized phenolic characteristics.
A comprehensive framework incorporating deep learning for analyzing fishing vessel activity using automatic identification system data
Authors: Han Fangcheng , Liu Yang , Tian Hao , Li Jianchao , Tian Yongjun 
Published: December 2024

Abstract
Automatic Identification System (AIS) has emerged as a crucial and cost-effective tool for monitoring ship behavior, widely employed in various fisheries. However, extracting meaningful insights from extensive AIS data to support fishery research remains challenging. In this study, we developed a framework integrating deep learning for marine fishing activity analysis, leveraging AIS data alongside marine environmental factors. Our approach utilized a transformer-based model with a majority vote for classifying fishing vessel types. The model achieved high accuracy, surpassing 90% in vessel type classification using a small subset of AIS records. Our framework employed the Temporal K-Means algorithm to efficiently identify fishing behavior, leveraging the time-series information of AIS data. Subsequently, it mapped fishing hours onto spatial grids to analyze the relationship between fishing activity and environmental factors. Correlation analysis revealed distinct preferences of different vessel types for environmental conditions, influencing their spatial distributions. Trawlers, for instance, exhibited sensitivity to seafloor bottom temperature, whereas seiners were primarily influenced by sea surface density (SSD) and sea surface temperature and gillnetters by SSD. Through this framework, we have established a coherent process to derive valuable insights about fishery resources from AIS data and guide fisheries management.