bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can the wet suction technique change the efficacy of EUS-FNA for diagnosing autoimmune pancreatitis type 1? A prospective single-arm study
Authors: Sugimoto Mitsuru , Takagi Tadayuki , Suzuki Rei , Konno Naoki , Asama Hiroyuki , Sato Yuki , Irie Hiroki , Watanabe Ko , Nakamura Jun , Kikuchi Hitomi , Takasumi Mika , Hashimoto Minami , Kato Tsunetaka , Hikichi Takuto , Notohara Kenji , Ohira Hiromasa 
Published: October 2019

Abstract
Background: Other than surgical biopsy, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the only method for histologically diagnosing autoimmune pancreatitis (AIP). However, adequate specimens are difficult to obtain. Recently, more adequate specimens were reported to be obtained with a wet suction technique (WEST) of EUS-FNA than with the conventional method of EUS-FNA. This study aimed to histologically diagnose AIP by EUS-FNA with a WEST. Methods: Eleven patients with possible type 1 AIP between February 2016 and August 2018 underwent WEST EUS-FNA (WEST group) with four punctures with 19 or 22 G needles. As a historical control, 23 type 1 AIP patients who underwent no fewer than four punctures with 19 or 22 G needles were selected (DRY group). Patient characteristics and histological findings were compared between the two groups. Results: Three histopathological items of the International Consensus Diagnostic Criteria were significantly greater in the WEST group than the DRY group (n (%), lymphoplasmacytic infiltrate without granulocytic infiltration: 9 (81.8) vs 6 (26.1), p value=0.003, storiform fibrosis: 5 (45.5.) vs 1 (4.3), p value=0.008, abundant (>10 cells/HPF) IgG4-positive cells: 7 (63.6) vs 5 (21.7), p value=0.026). Level 1 or level 2 histopathological findings were observed more in the WEST group than in the DRY group (n (%) 8 (72.7) vs 3 (13.0), p value=0.001). Conclusions: WEST EUS-FNA was more useful than standard EUS-FNA for histologically diagnosing AIP.Trial registration: UMIN000019768Date of registration: November 12, 2015
Prognostic Factors of Hilar Cholangiocarcinoma Patients After Surgical Resection
Authors: Liu Gangshan , Wu Shuodong , Zhao Jiannan , Li Xuecheng , Fan Ying 
Published: October 2019

Abstract
Background Hilar cholangiocarcinoma (HC)is one of the most common malignancies in China with poor prognosis and its incidence rate is increasing. Surgical resection is the most possible curative treatment option. However, comprehensive knowledge of prognostic markers is less or not accurate. So, the aim of this study was to analyze the prognostic factors in the surgical resection of HC patients.Material/Methods A retrospective analysis of 85 cases of HC patients attending our hospital between January 2014 and December 2018 were included in the study. The patients was follow-up history at July 2019. Cox proportional hazards model analysis was performed to identify indexes of prognosis. All indicators were analyzed by univariate and multivariate analysis.Results The significantly related prognostic factors are imaging staging,blood loss during surgery, lymphatic metastasis and tumor size,TNM stage, surgical mar­gin and level of carbohydrate antigen 19–9(CA19-9) in blood. Among them, TNM stage, surgical mar­gin and level of CA19-9 in blood are independent prognostic factors.Conclusions Good prognosis in hilar cholangiocarcinoma patients is indicated by early stages of TNM staging, no resection margin invaded and low level of CA19-9.
Awake Craniotomy vs Craniotomy Under General Anesthesia for Eloquent Glioma: Postoperative General Functional Preservation
Authors: Li Ying-Ching , Chiu Hsiao-Yean , Lin Ya-Jui , Chen Ko-Ting , Hsu Peng-Wei , Huang Yin-Cheng , Chen Pin-Yuan , Wei Kuo-Chen 
Published: October 2019

Abstract
Background Awake craniotomy (AC) with intraoperative stimulation mapping is the standard treatment for glioma, especially when present on the eloquent cortex. The purpose of this study was to investigate whether functional preservation after AC compromises patient survival as compared with craniotomy under general anesthesia (GA). Methods The medical records of 339 patients who underwent tumor resection surgery for gliomas from January 2010 to December 2014 were retrospectively reviewed. Among these patients, 62 underwent AC with intraoperative stimulation mapping. The primary outcome was the Eastern cooperative oncology group (ECOG) performance score at 3 months postoperatively. Secondary outcomes were the progression-free survival (PFS) and overall survival (OS). A generalized linear model and the Cox proportional hazard model were used to evaluate potential factors influencing general functional status and progression-free survival.Results The newly-diagnosed disease AC and repeat-surgery groups were comparable in terms of sex, age, pathologic grade, extent of resection (EOR) and preoperative Karnofsky Performance Status (KPS). Among the patients with newly-diagnosed disease, the postoperative ECOG score of the AC group was significantly better than that of the GA group. Pathologic grade and the EOR determined the PFS and OS in both the AC and GA groups.Conclusion AC with intraoperative stimulation mapping is safe and allows maximal removal of lesions around the eloquent cortex. Greater preservation of neurologic function may have resulted in a better postoperative general functional status in the AC group.
Integrated analysis of 14 lymphoma datasets revealed high expression of CXCL14 promotes cell migration in mantle cell lymphoma
Authors: Liu Dahai , Qi Fei , Liu Wei , Liu Fang , Xun Yang , Chen Min-Min , Chen Xin , Yang Shu-Ting , Jiao Wen-Qiao , Li Zong-Ye , Yang Hua , Li Wen-Xing 
Published: October 2019

Abstract
Background
Lymphoma is accompanied by multiple immune functions impairment. Cytokines play an important role in a variety of immune-related functions and affect the tumor microenvironment. However, the exact regulatory mechanisms between them remains unclear. This study aimed to explore the cytokines expression and function in Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).
Results
We performed a transcriptome integration analysis of 14 lymphoma datasets including 240 Hodgkin's lymphoma, 891 diffuse large B-cell lymphoma, 216 mantle cell lymphoma, and 64 health samples. The results showed that multiple immune function and signal pathway damage were shared by all the three types of lymphoma, and these functions were related to cytokines. Furthermore, through co-expression network and functional interaction network analysis, we identified CXCL14 as a key regulator and it affects cell chemotaxis and migration functions. Functional experiment showed that CXCL14 knockdown inhibited cell migration in MCL cell lines.
Conclusions
High expression of CXCL14 may aggravate MCL via promote cell migration. Our findings provide novel insights into the biology of MCL and would be helpful for the pathogenesis study and drug discovery of lymphomas.
Hemastatic biomarkers as prognostic factors in locoregionally advanced nasopharyngeal carcinoma treated with nimotuzumab plus chemoradiotherapy
Authors: Sun Jianda , Chen Zhijie , Xiong Jun , Zhang Hanxiong , Chen Yibiao , Zhong Zhixiong 
Published: October 2019

Abstract
Background: The prognostic value of hemostatic biomarkers in many tumors are well recognized. However, it remains unclear in locoregionally advanced nasopharyngeal carcinoma (NPC) patients treated with nimotuzumab plus chemoradiotherapy . In this study, we investigated pretreatment hemostatic biomarkers as prognostic factors for short-term efficacy after treatment.
Methods: In total, 101 patients with stage Ⅲ or stage Ⅳa NPC were enrolled from March 2016 to December 2018. All patients received chemoradiotherapy with concurrent nimotuzumab (200 mg/week) administration. Platelet count (PLT), prothrombin time (PT), international normalized ratio (INR), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) were collected before treatment.
Results: There was a statistically significant association between APTT and gender ( P =0.006), while PT and INR were found to be correlated with age ( P = 0.020 and P = 0.011, respectively). Prolonged PT or elevated INR was associated with a higher CR rate after treatment ( P = 0.008 and P = 0.003, respectively). Binary logistic regression analysis demonstrated that age, T category, N category, PT and INR were independent prognostic factors for primary tumor response, whereas N category and the overall stage could independently predict cervical lymph node response.
Conclusion: Pretreatment PT and INR may serve as useful prognostic biomarkers for predicting the primary tumor response to combined nimotuzumab and chemoradiotherapy in patients with locoregionally advanced NPC.
GoRoSoBo simplified: an accurate feedback control algorithm in real time for irrigation canals
Authors: Bonet Enrique , Gómez Manuel , Yubero M. T. , Fernández-Francos J. 
Published: October 2019

AbstractAn irrigation canal is a hydraulic system whose main objective is to convey water from a source (dam, river) to different users. Such systems can be very large (several tens or hundreds of kilometers), characterized by time delays and non-linear dynamics, strong unknown perturbations and interactions among subsystems. In order to fulfill the requirements of canal users, the water manager must control all water deliveries during the irrigation cycle (or irrigation program) calculating the gate positions of the canal according to the water demands in real time. Initially, our overall control diagram in real time is mainly represented by two algorithms, the canal survey estimation algorithm (this algorithm estimates the water level and velocity along the irrigation canal during a past time horizon) and GoRoSoBo algorithm (feedback control algorithm operating in real time). Regarding long canals with several gates and pumps operating in a short period of time for a long predictive horizon, the initial version of GoRoSoBo algorithms would spend too much time calculating the canal gate position in real time. This is the reason why we have upgraded the code of the GoRoSoBo algorithm, saving in computational time around 85%, in order to operate in real time.
Exploration of Mycelial Proteins from Aspergillus terreus Revealed Ribosome Biogenesis and Antioxidant Enzymes
Authors: Shishodia Sonia Kumari , Shankar Jata 
Published: October 2019

Background:
Aspergillus terreus is a major etiological agent among fungal pathogens and
emerged as an opportunistic pathogen in immunocompromised patients.

Methods:
The mycelial proteins of A. terreus cultured for 48h at 37°C have been analysed by using
nLC-ESI-MS/MS. Protein data analysis performed by Proteome Discoverer (V/2.2) against the
UniProt database. Also, Scanning Electron Microscopy (SEM) analysis of biofilm formation under optimum
conditions was carried out. qRT-PCR was carried out for genes encoding for functionally important
proteins.

Results:
A total of 389 proteins were detected at FDR 0.01. Gene ontology showed the abundance of
proteins from energy metabolism, cellular homeostasis, ribosome biogenesis, cell wall, and structural
components. We observed catalase, superoxide dismutase, thioredoxin, glutathione S-transferase involved
in redox homeostasis and heat shock proteins (Hsp90 and Hsp70). These proteins may provide
insight into the resistance mechanism of A. terreus against AmB. Additionally, SEM analysis of A.
terreus showed the formation of dense hyphal network covered with porous extracellular matrix
(ECM). Using SECRETOOL, 8 proteins were predicted as secretory. Three proteins, such as glucanase
Crf1/allergen (Asp F9), 1, 3-β-glucanosyltransferase and β-hexosaminidase were reported in biofilm
establishment.

Conclusion:
Our proteome data provided experimental evidence to the annotated set of proteins in A.
terreus that comprehend biochemical and cellular events involved in the establishment of mycelial
network and contributing to the pathogenesis. This work also provides resource for further molecular
studies in A. terreus.
Neuroleptic Malignant Syndrome: A Pilot Study on Psychiatric Inpatients in Iran
Authors: Shafti Saeed S. , Memarie Alireza , Rezaie Masomeh , Hamidi Masomeh 
Published: October 2019

Background:
Neuroleptic malignant syndrome is a life-threatening complication
that can occur anytime during antipsychotic treatment.

Objective:
The present assessment has probed the incidence and clinical profile of neuroleptic
malignant syndrome among a sample of non-western psychiatric patients and compared
with the available data in the literature with regard to prevalence and other associated
clinical physiognomies.

Methods:
As a retrospective, record-based evaluation, all cases with diagnosis of neuroleptic
malignant syndrome during the last sixty-two months, after ruling out other imaginable
differential diagnoses, like encephalitis, meningitis and serotonin syndrome, entered the
present investigation. Clinical diagnosis, was in essence also based on the Diagnostic and
Statistical Manual of Mental Disorders, 5th edition. The assessment of independent variables
was analyzed by ‘Compression of proportions’. Statistical significance is, defined as p
value ≤0.05.

Results:
Among 19814 psychiatric patients, during a sixty-two months’ period, eighteen
cases received the diagnosis of neuroleptic malignant syndrome. The most prevalent symptom
was fever, which was observed in 100% of cases. Also, there was no significant difference
between the first generation versus second-generation antipsychotics. Neuroleptic
malignant syndrome was meaningfully more prevalent among male patients suffering from
schizophrenia. Similarly, it was significantly more widespread amid 18-65 years old agegroup.

Conclusion:
While no significant difference was found between first-generation as opposed
to second-generation antipsychotics, neuroleptic malignant syndrome was significantly
more prevalent among young and male patients suffering from schizophrenia.
Resenha de 'Rousseau et le spectacle'
Authors: De Araújo e Viana Leite Rafael 
Published: October 2019

O novo livro sobre Jean-Jacques Rousseau, ao qual esta resenha se dedica, chama-se Rousseau et le spectacle, organizada por Christophe Martin (Universidade Paris-Ouest Nanterre La Défense), Jacques Berchtold (Universidade Paris-Sorbonne) e Yannick Séité (Universidade Paris VII-Diderot). O volume é fruto de um Colóquio internacional intitulado Rousseau et le spectacle, ocorrido entre 15 a 17 de março de 2012, na capital francesa, em ocasião das comemorações do tricentenário de nascimento de Rousseau.
Cinema e fotografia: as técnicas e suas ambiguidades em Benjamin, Flusser e Agamben
Authors: Ferrari Sonia Campaner Miguel 
Published: October 2019

O objetivo deste artigo é o de apresentar as concepções acerca das técnicas de Walter Benjamin, Vilém Flusser e Giorgio Agamben. No ensaio sobre a obra de arte Benjamin reflete sobre o cinema e as mudanças que a nova técnica introduz não só na concepção e função da arte na modernidade, mas também na percepção. Para ele as mudanças produzem uma reordenação da percepção e introduzem novas formas de sentir e perceber o mundo que correspondem a esse mundo. Portanto não há porque considerar essas mudanças como positivas ou negativas. As reflexões de Flusser são apresentadas a partir de seu Filosofia da caixa preta, em que o autor toma o fenômeno fotográfico para fazer um diagnóstico sobre a sociedade contemporânea, e que será estendido às outras técnicas em O Universo das imagens técnicas. A visão inicialmente pessimista de Flusser é nuançada nesta última obra. Agamben parece encontrar-se no ponto médio entre os dois pensadores ao definir o dispositivo, e o processo de profanação para combatê-lo. Palavras-chave: Técnica. Dispositivo. Aparato. Cinema. Fotografia.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF MENGGUNAKAN APLIKASI ADOBE DIRECTOR 11.5 MATA PELAJARAN BIOLOGI KELAS XI IPA
Authors: Harleni Harleni 
Published: October 2019

Banyaknya materi yang harus dikuasai siswa membuat mereka menjadi jenuh belajar biologi. Masih jarang adanya sumber belajar berupa media interaktif yang diberikan kepada siswa, karena keterbatasan biaya, kemampuan dan waktu yang dimiliki oleh sekolah.Salah satu media alternatif agar siswa termotivasi serta lebih mudah memahami materi pelajaran dancepat memahami konsep yang abstrak adalahpenggunaan media interkatif dengan Aplikasi Adobe director 11.5. Penelitian ini bertujuan untuk menghasilkan media interaktif yang valid dan praktis digunakan dalam pembelajaran.Jenis penelitian ini adalah penelitian pengembangan yang menggunakan model 4D yaitu define, design, develop, dan disseminate, tetapi tahap disseminate tidak dilakukan. Penelitiandilakukanmelalui uji validitas oleh 2 orang validator materi, 2 orang validator media dan uji praktikalitas pada 20 orang siswa di SMA N 1 Sungai Tarab kelas XI IPA1. Data uji validitas dan praktikalitas dianalisis dengan analisis deskriptif.
PEMBIBITAN DURIAN KUNYIT SEBAGAI USAHA PRODUKINTELEKTUAL KAMPUS
Authors: Dewi I.A.L. , Pradnyawathi N.M. , Sardiana I.K. , Darmiati N.N. 
Published: September 2019

Program pengembangan usaha produk intelektual kampus bertujuan untuk: (1) komersialisasi Ipteks kreativitas kampus sebagai sumber pembiayaan untuk pengebangan institusi; (2) memacu jiwa kewirausahaan dikalangan insan kampus, dan (3) membantu masyarakat mendapatkan bibit varietas Durian Kunyit. Metode pelaksanaan meliputi aspek bisnis perusahaan yang terdiri dari: penyediaan bahan baku, produksi, proses produksi, manajemen, pemasaran, sumberdaya manusia, fasilitas, dan financial. Bahan baku terdiri sumber batang bawah dari durian lokal, dan entris dari pucuk tanaman durian kunyit Produk yang dihasilkan berupa bibit Durian kunyit unggul dengan produktivitas di atas 60-70 biji /pohon, kapasitas produksi tahun 2018 yaitu sebanyak 2000 pohon. Proses produksi dimulai dari penyemaian batang bawah, penyambungan (grafting) batang bawah dengan batang atas, dan pemeliharaan. Manajemen usaha terdiri dari unit produksi dan pengembangan Ipteks, administrasi serta pemasaran. Pemasaran dilakukan secara langsung, kemitraan dengan Pemda dan konsiniasi dengan kios/toko pertanian. Sumberdaya manusia yang terlibat terdiri dari : 1 orang ketua, tiga kepala bidang, satu tenaga administrasi, dan 2 orang tenaga kerja operasional. Fasilitas yang tersedia berupa lahan kebun bibit seluas 1000 m2, ruang kantor dan nursery 100 m2.
Kata kunci : pembibitan , usaha, produk, intelektual kampus, durian kunyit.
Peningkatan Keamanan Pangan dalam Proses Produksi Keripik Singkong Pedas
Authors: Mardiana Mardiana , Z Intan 
Published: September 2019

Makanan khas Indonesia yang akrab dengan masyarakat adalah keripik singkong. Pengolahan yang berbeda akan mnambah kualitas rasa. Industri rumah tangga keripik singkong pedas 99 merupakan salah satu industri yang menggunakan bumbu alami tanpa bahan pengawet maupun penguat rasa. Pengolahan masih bersifat tradisional jika dilihat dari alat-alat yang digunakan. Saat ini pemasaran masih terbatas pada kantin-kantin rumah sakit, perusahaan, instansi pemerintah, perguruan tinggi dan sekolah. Keripik singkong pedas 99 banyak digemari oleh konsumen tetapnya karena rasa pedas asli yang khas dari cabai. Para pelanggannya berkomentar “sulit berhenti jika sudah mengkonsumsi keripik singkong pedas 99”.
Kegiatan yang dilakukan dalam kegiatan pengabdian ini adalah 1) pelatihan keamanan pangan bagi industri rumah tangga, 2) pelatihan manajemen Usaha, 3) demonstrasi pembuatan keripik singkong pedas sesuai standar resep, tangga, 4) pembuatan meja yang ergonomis

Kata Kunci : keripik singkong pedas ; pelatihan ; buku saku keamanan pangan
Penyuluhan dan Vaksinasi Ayam Buras di Desa Nyambu Kecamatan Kediri Kabupaten Tabanan
Authors: Kencana G.A.Y , Suartha IN. , Apsari I.A.P. , Sagung Kendran Anak Agung , Kade Suardana Ida Bagus 
Published: September 2019

Hospes utama penyakit Flu Burung adalah unggas termasuk ayam buras yang berpotensi tinggi sebagai penular dan penyebar penyakit karena sistim pemeliharannya secara semi intensif. Kasus kematian manusia akibat Flu Burung pernah terjadi di Banjar Batugaing Desa Beraban Kecamatan Kediri. Desa Nyambu terletak di Kecamatan Kediri, Kabupaten Tabanan. Populasi ayam buras di Kecamatan Kediri sebanyak 30.171 ekor pada tahun 2016. Mengingat potensi Desa Nyambu dengan penduduk yang kebanyakan memelihara ayam buras secara semi intensif, maka sangat rentan terjadinya penyebaran penyakit Flu Burung di Desa tersebut. Tujuan pengabdian masyarakat di Desa Nyambu adalah untuk mencegah timbulnya penyakit Flu Burung yang ditularkan oleh unggas. Sasaran utama adalah masyarakat yang memelihara ayam buras. Kegiatan pengabdian masyarakat diawali dengan penyuluhan yang dilakukan pada tanggal 28 Juli 2018 di Kantor Desa Nyambu. Peserta penyuluhan adalah aparat Desa beserta masyarakat setempat. Materi penyuluhan meliputi pengenalan gejala klinis penyakit Flu Burung dan cara mencegah dengan vaksinasi. Vaksinasi pada ayam buras dilakukan dari satu rumah ke rumah lainnya (door to door) dengan menggunakan vaksin AI inaktif melalui suntikan intramuskuler pada paha. Sebanyak 230 ayam buras berbagai umur telah berhasil divaksinasi.
Kata kunci: penyuluhan, vaksinasi, Flu Burung, ayam buras, Tabanan.
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN DAN LOYALITAS MAHASISWA PADA INSTITUTE OF BUSINESS (IOB) DI TIMOR-LESTE
Authors: ALARICO BARRETO XIMENES NATALINO 
Published: September 2019

The aim of this study is to understand the influence of the service quality for the student satisfaction and loyalty. To keep compete on the path, IOB should maintain the good service quality to its students, in order to gain the loyalty from its students. Therefore, with the good quality services, IOB could stand on the competition.
Respondent of this study are the active IOB students, with age minimum 17 years old and maximum 35 years old. The total respondent for this study is 104 respondents, using the purposive sampling technique, and Structural Equation Modeling (SEM) as the data analysis tool. The result of this study showed that the hypothesis put forward entirely acceptable: 1) service quality has positive and significant impact on student satisfaction, 2) service quality has positive and significant impact on student loyalty, 3) student satisfaction has positive and significant impact on student loyalty. Managerial implication from this study is the management of IOB should have regular evaluation for its service quality, and also perform correction and improvement to reduce students complains, in order to increase the student satisfaction and loyalty.
PENDEKATAN TAM DALAM LAYANAN GO-MASSAGE PADA APLIKASI GO-JEK
Authors: Widasari Ni Putu Wulan , Wardana I Made , Setiawan Putu Yudi 
Published: September 2019

ABSTRACT
The meaning of this research wants to explain the effect of perceived ease of use, perceived usefulness, and perceived risk towards attitude and purchase intention of Go-Massage on Go-Jek application. The population of this study is not limited (infinite) which is the user Go-Jek application in Denpasar. The sample in this study was taken with non-probability sampling technique with 120 respondents. The result shows that perceived ease of use and perceived of usefulness have positive and significant effect towards attitude. Furthermore, the results of the study also showed a positive and significant effect of perceived usefulness and attitude towardspurchase intention. Conversely, risk perceptions have a negative and significant effect on attitude and purchase intention. The theoretical implication of this research is that this research reinforces the attitude theory especially the Technology Acceptance Model proposed by Davis (1989). Practical implications are useful for companies to explore the construct which gives significant effect towards purchase intention. In the future, the company should focus more on perceived usefulness to encourage customer’s purchase intention towards Go-Massage service offered on Go-Jek application
Keywords: TAM, Perceived Ease of Use, Perceived Risk, Attitude, and Purchase Intention