bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteome analysis of peroxisomes from dark‐treated senescent Arabidopsis leaves
Authors: Pan Ronghui , Reumann Sigrun , Lisik Piotr , Tietz Stefanie , Olsen Laura J. , Hu Jianping 
Published: June 2018

AbstractPeroxisomes compartmentalize a dynamic suite of biochemical reactions and play a central role in plant metabolism, such as the degradation of hydrogen peroxide, metabolism of fatty acids, photorespiration, and the biosynthesis of plant hormones. Plant peroxisomes have been traditionally classified into three major subtypes, and in‐depth mass spectrometry (MS)‐based proteomics has been performed to explore the proteome of the two major subtypes present in green leaves and etiolated seedlings. Here, we carried out a comprehensive proteome analysis of peroxisomes from Arabidopsis leaves given a 48‐h dark treatment. Our goal was to determine the proteome of the third major subtype of plant peroxisomes from senescent leaves, and further catalog the plant peroxisomal proteome. We identified a total of 111 peroxisomal proteins and verified the peroxisomal localization for six new proteins with potential roles in fatty acid metabolism and stress response by in vivo targeting analysis. Metabolic pathways compartmentalized in the three major subtypes of peroxisomes were also compared, which revealed a higher number of proteins involved in the detoxification of reactive oxygen species in peroxisomes from senescent leaves. Our study takes an important step towards mapping the full function of plant peroxisomes.
The crossroads of receptor‐mediated signaling and endocytosis in plants
Authors: Claus Lucas Alves Neubus , Savatin Daniel V. , Russinova Eugenia 
Published: June 2018

AbstractPlants deploy numerous plasma membrane receptors to sense and rapidly react to environmental changes. Correct localization and adequate protein levels of the cell‐surface receptors are critical for signaling activation and modulation of plant development and defense against pathogens. After ligand binding, receptors are internalized for degradation and signaling attenuation. However, one emerging notion is that the ligand‐induced endocytosis of receptor complexes is important for the signal duration, amplitude, and specificity. Recently, mutants of major endocytosis players, including clathrin and dynamin, have been shown to display defects in activation of a subset of signal transduction pathways, implying that signaling in plants might not be solely restricted to the plasma membrane. Here, we summarize the up‐to‐date knowledge of receptor complex endocytosis and its effect on the signaling outcome, in the context of plant development and immunity.
German Wage Moderation and European Imbalances: Feeding the Global VAR with Theory
Authors: BETTENDORF TIMO , LEÓN‐LEDESMA MIGUEL A. 
Published: June 2018

AbstractGerman labor market reforms in the 1990s and 2000s are generally believed to have driven the large increase in the dispersion of current account balances in the Euro Area. We investigate this hypothesis quantitatively. We develop a three‐region open economy New Keynesian model with search and matching frictions from which we derive robust sign restrictions for wage bargaining and matching efficiency shocks which we term wage moderation shocks. We impose these restrictions on a Global VAR consisting of Germany and eight EMU countries to identify a wage moderation shock in Germany. Our results show that, although the German current account was significantly affected by wage moderation shocks, their contribution to European current account imbalances was negligible. We conclude that the German labor market reforms cannot be the lone driver of European imbalances.
Uterine Incarceration: A Case Study
Authors: Lawrence Allison , Morelli Erin , Simoni Michael , Illuzzi Jessica 
Published: June 2018

AbstractUterine incarceration is a rare complication of pregnancy in which a retroverted uterus becomes entrapped in the pelvis. This case report describes the clinical presentation and management of a woman with a suspected uterine incarceration in the late first trimester. This article reviews the diagnosis of uterine incarceration, including differential diagnoses, signs and symptoms, and the role of imaging. Management is based on the gestational age at the time of diagnosis. Management options are described along with a discussion of the available evidence.
Does Surgical Crown Lengthening Procedure Produce Stable Clinical Outcomes for Restorative Treatment? A Meta‐Analysis
Authors: Al‐Sowygh Zeyad H. 
Published: June 2018

AbstractPurposeThe present systematic review was designed to assess whether surgical crown lengthening (SCL) procedure produces stable clinical outcomes for restorative treatment.MethodsBased on the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines, a specific PICO question was constructed: “Does the SCL procedure produce stable clinical outcomes for restorative treatment?” Electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register) were searched up to December 2017. The risk of bias was assessed based on the revised recommendations of the Consolidated Standards of Reporting Trials (CONSORT) statement. Forest plots were computed reporting weighted mean difference (WMD) of outcomes and 95% confidence intervals (CI) for crown length (CL), position of gingival margin (PGM), biological width (BW), and bone level changes.ResultsFive studies were included. The risk of bias was considered high in all studies. A high degree of heterogeneity was noticed for CL, PGM, and BW. The overall mean difference for CL (WMD = −1.84, 95% CI = −0.103 to 2.05, p = 0.076), PGM (WMD = 0.87, 95% CI = 0.12 to 1.62, p = 0.02), and BW (WMD = −0.11, 95% CI = −2.21 to 1.99, p = 0.91) were not significant at follow‐up. The overall mean difference for bone level changes was significant (WMD = 1.64, 95% CI = 1.26 to 2.03, p < 0.001) at follow‐up.ConclusionIt remains debatable whether SCL produces gingival rebound, or re‐establishes BW and changes in clinical attachment level; however, further studies with low risk of bias randomized CCTs and long‐term follow‐up are recommended to reliably assess the restorative outcomes of SCL.
How Differences in Cash Transfer Sizes Affect Work Allocation Decisions: Evidence from Cross‐Country Comparisons in SSA
Authors: Prifti Ervin , Estruch Elisenda , Daidone Silvio , Davis Benjamin 
Published: June 2018

AbstractOver the past decade, several African governments have launched Cash Transfer (CT) programmes as part of their social protection systems, with the aim of reducing poverty. Such programmes can also have significant productive impacts. We use data from four major CT programmes implemented in sub‐Saharan Africa to estimate their impacts on labour supply and demand and how effects change in relation to transfer size. We find evidence of labour reallocation between farm and off‐farm work and limited evidence of monotonicity of the labour supply–transfer size relationship.
Applications of genomics to slow the spread of multidrug‐resistant Neisseria gonorrhoeae
Authors: Mortimer Tatum D. , Grad Yonatan H. 
Published: June 2018

AbstractInfections with Neisseria gonorrhoeae, a sexually transmitted pathogen that causes urethritis, cervicitis, and more severe complications, are increasing. Gonorrhea is typically treated with antibiotics; however, N. gonorrhoeae has rapidly acquired resistance to many antibiotic classes, and lineages with reduced susceptibility to the currently recommended therapies are emerging worldwide. In this review, we discuss the contributions of whole genome sequencing (WGS) to our understanding of resistant N. gonorrhoeae. Genomics has illuminated the evolutionary origins and population structure of N. gonorrhoeae and the magnitude of horizontal gene transfer within and between Neisseria species. WGS can be used to predict the susceptibility of N. gonorrhoeae based on known resistance determinants, track the spread of these determinants throughout the N. gonorrhoeae population, and identify novel loci contributing to resistance. WGS has also allowed more detailed epidemiological analysis of transmission of N. gonorrhoeae between individuals and populations than previously used typing methods. Ongoing N. gonorrhoeae genomics will complement other laboratory techniques to understand the biology and evolution of the pathogen, improve diagnostics and treatment in the clinic, and inform public health policies to limit the impact of antibiotic resistance.
The story of life: critical insights from evolutionary biology
Authors: Paulson Steve , Chang Melanie Lee , Tattersall Ian , Morris Simon Conway 
Published: June 2018

AbstractThe notion that humans, in all their complexity, are merely an evolutionary accident, an insignificant speck in a boundless cosmos, is deeply unsatisfying for most nonscientists and fails to resonate with their life experience. What, then, can evolutionary biology ultimately tell us about the meaning of our lives? In conversation with Steve Paulson, executive producer and host of To the Best of Our Knowledge, paleoanthropologists Melanie Lee Chang and Ian Tattersall, and paleontologist Simon Conway Morris share their insights on these competing concepts and explain how meaning and purpose can be gleaned from the remarkable story of life itself.
Utility of gabapentin in meeting physical therapy goals following posterior spinal fusion in adolescent patients with idiopathic scoliosis
Authors: Thomas James J. , Levek Claire , Quick Hannah D. , Brinton John T. , Garg Sumeet , Cohen Mindy N. 
Published: June 2018

SummarySummary of Background DataPosterior spinal fusion surgery for scoliosis requires extensive postoperative analgesic care. In 2014, we initiated the use of gabapentin as an adjunct for multimodal pain management in spine fusion patients. The effect of gabapentin on postoperative recovery in scoliosis patients was evaluated using the time to meet postoperative physical therapy goals. This measure was chosen because the actions required to achieve the goals are specific and reproducible. Secondary outcomes included morphine equivalents and maximum pain scores.AimsThe purpose of this study was to evaluate the effects of gabapentin on time to achieve physical therapy goals following posterior spinal fusion in adolescents with scoliosis.MethodsA retrospective chart review was performed and patients treated perioperatively with gabapentin were compared with those who did not receive gabapentin. Outcome measures included the postoperative day that physical therapy goals were met, days to discharge, morphine equivalents, and maximum pain scores. The 4 physical therapy goals included logroll, transition from lying to sitting, ambulate 250 feet, and ascend/descend at least 3 stairs.ResultsThere were 50 patients in the gabapentin group and 51 patients in the control group. In the gabapentin group, there was a statistically significant decrease in the time required to meet physical therapy goals. Notably, gabapentin was independently associated with a 5.34 times higher odds of completion of the most challenging physical therapy goal (stairs) within 1 day (P = .04; 95% CI=1.24‐37.44). There was not a statistically significant difference in length of hospital stay between the groups (P = .116; 95% CI=0‐1).ConclusionIn this retrospective analysis, the use of perioperative gabapentin is associated with a statistically significant decrease in time to completing physical therapy goals after spinal fusion for adolescent idiopathic scoliosis.
Ambiguity and Zeugma
Authors: Viebahn Emanuel 
Published: June 2018

AbstractIn arguing against a supposed ambiguity, philosophers often rely on the zeugma test. In an application of the zeugma test, a supposedly ambiguous expression is placed in a sentence in which several of its supposed meanings are forced together. If the resulting sentence sounds zeugmatic, that is taken as evidence for ambiguity; if it does not sound zeugmatic, that is taken as evidence against ambiguity. The aim of this article is to show that arguments based on the second direction of the test are misguided: ambiguous expressions, and in particular philosophically contested ones, do not reliably lead to zeugmaticity, so an absence of zeugmaticity provides no meaningful evidence for an absence of ambiguity.
Analysis of faith
Authors: Rettler Bradley 
Published: June 2018

AbstractIn recent years, many philosophers of religion have turned their attention to the topic of faith. Given the ubiquity of the word “faith” both in and out of religious contexts, many of them have chosen to begin their forays by offering an analysis of faith. But it seems that there are many kinds of faith: religious faith, non‐religious faith, interpersonal faith, and propositional faith, to name a few. In this article, I discuss analyses of faith that have been offered and point out the dimensions along which they differ.
Can swap line arrangements help solve the Triffin dilemma? How?
Authors: Seghezza Elena 
Published: June 2018

AbstractThe recent massive rise in the currency reserves of emerging countries has once again brought the Triffin dilemma to the fore, albeit different to the past. At all the events, new tools for the creation of international liquidity emerged during the global financial crisis of 2007–08, including bilateral swap line arrangements (BSAs). These arrangements ultimately constitute a form of lending of last resort. Therefore, for emerging countries, they can substitute currency reserves and help resolve the Triffin dilemma. In this manner, the stipulation of BSAs by advanced countries, although motivated by domestic reasons, contributes to international financial stability. Providing access to these arrangements automatically would contradict the principle of constructive ambiguity and the discretion that should be at the base of the lending of last resort also at the international level.
Longitudinal Study of Effectiveness of a Patient‐Centered Self‐Management Empowerment Intervention During Predischarge Planning on Stroke Survivors
Authors: Chen Lu , Chen Yan , Chen Xiangyu , Shen Xiaofang , Wang Qing , Sun Chunyan 
Published: June 2018

ABSTRACTPurposeTo examine the effectiveness of a patient‐centered self‐management empowerment intervention (PCSMEI) on self‐efficacy, activities of daily living (ADL), and rehospitalization of first‐time stroke survivors.MethodsOne hundred forty‐four first‐time stroke survivors were recruited from a comprehensive hospital in China. The intervention group (IG; n = 72) received a PCSMEI, whereas the control group (CG; n = 72) received routine care. The data on self‐efficacy and ADL were collected at baseline (T0), on discharge (T1), 1‐month postdischarge (T2), and 3 months postdischarge (T3) while the rehospitalization was collected at T2 and T3. The general estimation equations model was used to examine the effects of the PCSMEI program on the outcome variables.ResultsOne hundred twenty‐six participants finished the study (IG: n = 64; CG: n = 62). Compared with the CG, patients in the IG showed significant higher level in self‐efficacy on discharge (p = .014), 1‐month postdischarge (p = .008), and 3 months postdischarge (p = .023), and higher level in ADL at 3 months postdischarge (p = .044). The rehospitalization rate of the IG was lower than that in the CG at 1‐month postdischarge and 3 months postdischarge, which had clinical significance.Linking Evidence to ActionPCSMEI is of great value to stroke patients. This paper forms the basis for more widespread implementation of PCSMEI.
Mirror, Mirror on the Wall: A Dancer, Her Psychosis, and the Black Swan of the Real
Authors: Stephenson Laura 
Published: June 2018

Jacques Lacan argues that self-identification occurs when individuals first see a mirror image of themselves, known in psychoanalytic theory as ‘The Mirror Phase’. Because the individual identifies with this image outside of the self, subjectivity is based upon alienation and misrecognition, creating a dualistic split in the human psyche, and a space between the Imaginary of infancy and the Symbolic of adulthood.Using Black Swan (2010) as a cinematic case study this paper addresses what happens when an individual, during an episode of psychological disturbance (acute psychosis), encounters that problematic space, the Real, in a manner that propels them back into the pre-Mirror stage conflict with the image over an increasingly disarrayed subjectivity. Nina’s psychosis is articulated by the onset of a series of hallucinations, which take place in front of mirrors, signaling the disruptive regression to her infantile mirror phase where she has no unified sense of self.Her psychotic hallucinations are the emergence of the horrific Real, erupting through her reality as she battles with a subjectivity founded on fragmentation and separation. Nina’s cinematic interaction with the Real visually portrays the tension between her malevolent inner ‘black swan’ and the innocent ‘white swan’ that functions as her imago.
Storytelling for Our Own People: A Reflection on Working with Māori Filmmaker Barry Barclay
Authors: Milligan Christina 
Published: June 2018

Māori film director and writer Barry Barclay is recognized among international indigenous filmmakers as a foundational figure. As a philosopher and a filmmaker, he was fierce in pursuit of what he saw to be tika, that which is true, upright and just. He worked in an often expensive, always collaborative medium, and his unwillingness to compromise was sometimes seen as intransigence. He was thus frequently at odds, not just with mainstream film funders and distributors, but also with some of his compatriots in the world of Māori filmmaking. Yet from my perspective as a producer working with him late in his career, the process of developing a screenplay with him was a constructive, deeply creative experience where disagreements were always focused on enhancing the work itself. While he is best known as a film director, this article is a practice-led exploration of his work as a screenwriter as revealed through two film scripts we worked on in the years between 1995 and 2007. It discusses his process as a screenwriter on these films, exploring his strengths as a writer while also placing these two projects within the wider frame of his complete oeuvre.
Family networks and infant health promotion: a mixed-methods evaluation from a cluster randomised controlled trial in rural Malawi
Authors: Scott Molly , Malde Bansi , King Carina , Phiri Tambosi , Chapota Hilda , Kainja Esther , Banda Florida , Vera-Hernandez Marcos 
Published: June 2018

ObjectiveParents may rely on information provided by extended family members when making decisions concerning the health of their children. We evaluate whether extended family members affected the success of an information intervention promoting infant health.MethodsThis is a secondary, sequential mixed-methods study based on a cluster randomised controlled trial of a peer-led home-education intervention conducted in Mchinji District, Malawi. We used linear multivariate regression to test whether the intervention impact on child height-for-age z-scores (HAZ) was influenced by extended family members. 12 of 24 clusters were assigned to the intervention, in which all pregnant women and new mothers were eligible to receive 5 home visits from a trained peer counsellor to discuss infant care and nutrition. We conducted focus group discussions with mothers, grandmothers and peer counsellors, and key-informant interviews with husbands, chiefs and community health workers to better understand the roles of extended family members in infant feeding.ResultsExposure to the intervention increased child HAZ scores by 0.296 SD (95% CI 0.116 to 0.484). However, this effect is smaller in the presence of paternal grandmothers. Compared with an effect size of 0.441 to 0.467 SD (95% CI −0.344 to 1.050) if neither grandmother is alive, the effect size was 0.235 (95% CI −0.493 to 0.039) to 0.253 (95% CI −0.529 to 0.029) SD lower if the paternal grandmother was alive. There was no evidence of an effect of parents’ siblings. Maternal grandmothers did not affect intervention impact, but were associated with a lower HAZ score in the control group. Qualitative analysis suggested that grandmothers, who act as secondary caregivers and provide resources for infants, were slower to dismiss traditionally held practices and adopt intervention messages.ConclusionThe results indicate that the intervention impacts are diminished by paternal grandmothers. Intervention success could be increased by integrating senior women.
Obesity and sickness absence: results from a longitudinal nationally representative sample from Germany
Authors: Reber Katrin Christiane , König Hans-Helmut , Hajek André 
Published: June 2018

ObjectivesThe current study aimed at investigating the longitudinal association between obesity and sickness absence in women and men in Germany.MethodsData were derived from the German Socio-Economic Panel (GSOEP) which is a nationally representative, longitudinal study of private households in Germany. We draw on data from 2002 to 2012. Information on self-rated body mass index has been collected every second wave since 2002. Sick leave days (total number of working days missed due to illness in the past calendar year) and sick from work for more than 6 weeks in the preceding 12 months (yes/no) were used as outcome measures. Fixed-effects (FE) regression models were used for the total sample and stratified by sex. Gender differences were examined using interaction terms (sex × weight category).ResultsControlling for several potential confounders, Poisson FE regression analysis showed that transitions from normal weight to obesity were associated with an increase in sick leave days in women (incidence rate ratio (IRR) 1.27, 95% CI 1.02 to 1.57) but not in men (IRR 0.85, 95 % CI 0.68 to 1.06)—with significant gender differences (sex × obesity, p<0.01). Moreover, conditional FE logistic regressions showed that transitions from normal weight to overweight were associated with an increase in the probability of long-term absenteeism in women (overweight, OR 1.41, 95% CI 1.08 to 1.85) but not in men (overweight, OR 0.84, 95% CI 0.65 to 1.09). Gender differences were significant (sex × overweight, p<0.01).ConclusionsOur findings stress the longitudinal association between excess weight and increased likelihood of sick leave days as well as long-term absenteeism in women.