bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study
Authors: Rodríguez Arnao María Dolores , Rodríguez Sánchez Amparo , Díez López Ignacio , Ramírez Fernández Joaquín , Bermúdez de la Vega Jose Antonio , Yeste Fernández Diego , Chueca Guindulain María , Corripio Collado Raquel , Pérez Sánchez Jacobo , Fernández González Ana , _ _ 
Published: September 2019

Background
Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic device.

Methods
National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod™ for at least 3 months before inclusion. The follow-up period was 4 years.

Results
Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups.

Conclusions
The easypod™ electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatment.
Morphological and Functional Alterations of the Cardiovascular System during Acute Clozapine Poisoning (Experimental Study)
Authors: Babkina A. S. , Ryzhkov I. A. , Antonova V. V. , Tsokolaeva Z. I. , Asanov A. R. , Kalabushev S. N. , Zarzhetsky Yu. V. 
Published: September 2019

Purpose of the study. To evaluate the influence of sublethal dose of Clozapine on the functional and morphological parameters of the cardiovascular system in rats 4 hrs. after the drug administration.Materials and methods. The experiments were carried out on male Wistar rats weighing 200–250g (n=14). Group I received 0.9% NaCl solution administered via enteral feeding tubing under general anesthesia using Sevoflurane; group II — Clozapine dosed at 150 mg/kg in 0.9% NaCl solution; group III — Clozapine dosed at 150 mg/kg in 40% ethyl alcohol solution. 4 hrs. after drug administration, arterial blood pressure (ABP), heart rate (HR), microcirculation in the skin using laser Doppler flowmetry (LSF), fluorescence intensity of coenzymes NADH and FAD were evaluated. After euthanasia, autopsy including withdrawal of the internal organs of rats for morphological analysis was performed. Thereafter, paraffin sections of hearts were made and subsequently stained with hematoxylin and eosin, which were later examined with the help of light microscope Nikon Eclipse Ni-U.Results. In both Clozapine groups, ABP and blood flow in the skin were lower than in the control group: ABP — by 12% in group I and by 15% in group II; blood flow — by 48% and 37%, respectively. No significant difference between the groups was observed in respect of the microcirculation indices studied. Increased fluorescence intensity of coenzyme NADH in the skin was found in the Clozapine groups compared to the control group (2.3-fold in group I and 1.9-fold in group II). Histological analysis of the hearts of animals that received Clozapine established uneven blood filling, erythrocyte sludges, fine-focal hemorrhaging, endotheliocyte nuclei oriented perpendicular to the basal membrane, uneven staining of myocardium with hypereosinophilic segments, fragmentation and undulating deformity of muscle fibers.Conclusion. During acute Clozapine poisoning, morphological signs of disturbed circulation and myocardium damage are found in the heart, which are accompanied with development of myocardium dysfunction with arterial hypotension and decreased peripheral blood flow, also disturbed oxidative metabolism in peripheral tissues.
Prevention of Gut Barrier Dysfunction During Acute Massive Blood Loss (Experimental Study)
Authors: Yakovlev A. Y. , Boyarinov G. A. , Ryabikov D. V. , Ryabikova M. A. , Protasov D. M. , Mukhina I. V. 
Published: September 2019

Purpose of the study: to investigate the influence of hypovolemia correction by infusion of malate-containing preparations and subsequent glutamine-enriched nutritional support on the maintenance of gut barrier and overhydration in animals with acute massive blood loss/ Materials and methods. Blood samples were harvested from the tail and portal veins of rats (n=100) at different time points after the acute blood loss (>30% V/V) . Bacterial blood cultures for growth, lipopolysaccharide and presepsin concentrations, colon structures and animal weight were analyzed in blood and plasma specimens 1 hour, one day and 3 days after the hypovolemia correction. To correct the hypovolemia, in the 1st series of experiments, the Ringer’s solution and standard nutrient mixture were used; in the 2nd series malatecontaining solution and standard nutrient mixture were administered; in the 3rd series a malate-containing solution and glutamine-enriched nutrient mixture were employed.Results. In the portal vein blood of intact animals, endotoxin measurement was equal to 17.8Ѓ}3.9 pg/ml, that of presepsin — 405.6Ѓ}80.1 pg/ml. At all stages, tail and portal blood bacterial cultures were negative demonstrating an absence of bacterial growth and gut barrier intactness for live microorganisms. One hour after hypovolemia correction and blood reinfusion, multifold increase in endotoxin concentration in the blood from both portal and tail veins was accompanied by significant increase of presepsin concentration. 24 hours after the blood loss, in the animals of the 2nd and 3rd series, the levels of endotoxin, presepsin, and edema of the colon mucous membrane and submucosal space has become lower than those in the 1st series. Three days later, the advantages of glutamine-containing nutrition in the 3rd series of the experiment were determined that revealed decreasing the endotoxin and presepsin concentrations in the portal and tail vein blood and diminishing the levels of interstitial edema of colon and animal weight growth.Conclusion. Administration of malate-containing infusion preparations and glutamine-enriched nutrition after an acute massive blood loss contributes to decreasing presepsin production in GIT organs, abrogating endotoxin translocation into the portal vein and systemic circulation, lessening severity of edema of the mucous membrane and submucosal space of the colon, and reducing the previously increased animal body mass.
Roman-Period Mystery Cults as the Focal Points of Cursing Rituals?
Authors: Faraone Christopher A. 
Published: September 2019

Summary
The recently published curse tablets from the sanctuary of Magna Mater in Mainz, from the hero shrines of Opheltes and Palaimon, and from the sanctuary of Demeter and Kore, as well as a single curse tablet from late Roman Antioch invoking the “secret names” of the Samothracian deities, all suggest some connection between mystery religions and cursing. Two possible explanations are explored: (i) because initiates had special access to divine powers, their curses were thought to be especially powerful; or (ii) because these new discoveries fit two traditional types of defixiones: those placed in or at the graves of those violently killed, like Opheltes, or those placed in sanctuaries of female divinities, like Demeter, whose myths focus on the loss and return of a loved one from Hades.
Mitra-Mithra-Mithras: The Roman Mithras and His Indo-Iranian Background
Authors: Lahe Jaan 
Published: September 2019

Summary
One of the key questions in the studies of the Roman cult of Mithras has been, since the works of F. Cumont, the question about the religious historical origin of the cult – regarding which there is no consensus to this day. Theories about the origin of the cult can be divided into three groups: (1) the so-called “strong” Iranian thesis, according to which the cult was imported from Iran; (2) the so-called “weak” Iranian thesis, claiming that just a few, mostly irrelevant elements of the cult originated in Iran; (3) a radical stance that there is no consistency between the Roman cult of Mithras and the Iranian cult of Mithra and what the two have in common is simply the similar name of a god. The author of this presentation has studied comparatively the character of Mitra in Indian religious literature, that of Mithra in Iranian religious and mythological texts as well as in Iranian religious iconography, and Mithras in the cult devoted to him in Rome, and has concluded that the radical belief common in current Mithras studies, according to which Mithras is connected with Mitra and Mithra only by them having similar names, is just as erroneous as the “strong” Iranian thesis defended by F. Cumont and G. Widengren. Although it is certain that the Roman cult of Mithras is not a cult imported from Iran, but a new cult that originated in the Roman Empire, the author of this presentation maintains that the Roman cult of Mithras contains a series of motifs that can be found both in the Vedas and in Iranian mythological texts: connection of Mitra/Mithras with friendship and a contract of friendship; certain military traits; connection with cosmogony and the cosmic order; connection with light, the Sun and the chariot of Sol; the role of the god as a giver of water and fertility; the idea of a sacrifice that stimulates fertility. Based on the sources linked to the Roman Mithras, in particular the iconography, it may be claimed that a large part of these motifs did not have a peripheral role in the mythology connected with the cult, but they carried an important, maybe even a central role. As the previously mentioned motifs were already interrelated in India and Iran, the author of this presentation believes that their coexistence in the mythology of the Roman cult of Mithras cannot be a coincidence but testifies to the wider Indo-Iranian background of the central figure of the cult, the god Mithras, which should not be ignored even if the Roman cult of Mithras is viewed as a new cult that evolved in the Roman Empire and within the context of the Greco-Roman religion.
Egyptianism
Authors: Gasparini Valentino , Gordon Richard L. 
Published: September 2019

Summary
When dealing with Isis, Serapis and the other members of the so-called ‘gens isiaca’, scholars have hesitated whether to emphasize their (indisputable) historico-geographic origin in the Nile valley or their (no less indisputable) character as Graeco-Roman cults. We thus find these deities referred to as ‘Egyptian’, ‘Graeco-Egyptian’, ‘Graeco-Roman’, ‘Greek’, ‘Roman’ and, again, ‘Oriental’, ‘Orientalized Roman’, and so on. Each of these definitions is evidently partial, which is one reason for the growing preference for the less specific terms ‘Isiac gods’ and ‘Isiac cults’. Yet even these elide the problem of how these cults were perceived in relation to Egypt. This article aims to challenge the terms of the conventional dichotomy between Egyptian and Graeco-Roman, by exploring the many specific contexts in which ‘Egypt’ was appropriated, for example, by institutions, intellectuals (e.g. ‘Middle-’ and Neo-Platonists), Christian apologists, late-antique encyclopedists, etc. Starting with the comparandum ‘Persianism’ recently highlighted in relation to the cult of Mithras, the paper will explore the various interests and aims involved in the construction of ideas of Egypt, which might even involve more than one ‘Egyptianism’ at the same time. Each of our nine suggested ‘Egyptianisms’ is the creation of numerous ‘producers’, who adapted what they knew of ‘Egypt’ (‘foreign’, ‘exotic’, ‘other’) to create their own religious offers. Our basic model is derived from the Erfurt project Lived Ancient Religions, which inverts the usual representation of ancient religion as collective (‘polis religion’, ‘civic religion’) in favour of a perspective that stresses individual agency, sense-making and appropriation within a range of broader constraints.
Polyethylene plastic production process
Authors: Zhong Xiuhua , Zhao Xudong , Qian Yongkang , Zou Yan 
Published: September 2019

<p>Polyethylene has become the most important polyoleﬁn plastic with excellent mechanical properties, processing properties and chemical stability. It is used in the production of film, packaging and pipe. However, the non-polar property and low rigidity limit its application in certain ﬁelds. The new progress of chemical and physical modiﬁcation upon polyethylene are reviewed. The former includes graft modification, chlorination, copolymerization modification, crosslinking modification, chlorosulfonation modification and plasma modification. There are different methods of polyethylene production which include high-, medium- and low-pressure polyethylene. All three methods had their own beneﬁts and shortcomings which coexist in the industry. <br /><br /></p>
The Sloth
Authors: Lederman Michael M. , Kuritzkes Daniel R. 
Published: September 2019

I nearly saw a three-toed slothI really hoped to see oneBut as I crept up on the beastHe sped off like a demon How did this lazy fellow do it?My legs were gelled, encased in suetInsensate speed was needed nowThat wily sloth could sprint, and how!I called upon my last reservesTo stay with him through streams and curvesHe would not give this race a restJust like those hounds of BudapestHis limbs a blur, his eyes agleamHis ears pressed back, his goggles seemTo mask his real intent, his dreamTo master speed and be the Dean Of hustle.
The Menstrual Cycle May Affect Anterior Knee Laxity and the Rate of Anterior Cruciate Ligament Rupture
Authors: Somerson Jeremy S. , Isby Ian J. , Hagen Mia S. , Kweon Christopher Y. , Gee Albert O. 
Published: September 2019

Background:
Women have a higher risk of anterior cruciate ligament (ACL) tears than men, the causes of which are multifactorial. The menstrual cycle and its hormonal effect on the knee may contribute to knee laxity and ACL injury. This work reviewed published studies examining the effects of the phases of the menstrual cycle on anterior knee laxity and the rate of ACL tears.

Methods:
A systematic review with meta-analysis and meta-regression was performed. Studies with data comparing the menstrual cycle phase with ACL injury or anterior knee laxity were included for analysis. Data with regard to patient demographic characteristics, anterior knee laxity, ACL injury, and menstrual cycle phases were extracted from the included studies.

Results:
In this study, 1,308 search results yielded 396 articles for review, of which 28 met inclusion criteria. Nineteen studies of knee laxity with 573 combined subjects demonstrated a mean increase in laxity (and standard deviation) of 0.40 ± 0.29 mm in the ovulatory phase compared with the follicular phase and a mean increase in laxity of 0.21 ± 0.21 mm in the luteal phase compared with the follicular phase. Nine studies examining ACL tears with 2,519 combined subjects demonstrated a decreased relative risk (RR) of an ACL tear in the luteal phase compared with the follicular and ovulatory phases combined (RR, 0.72 [95% confidence interval, 0.56 to 0.89]). There were no differences in ACL tear risk between any of the other phases.

Conclusions:
An increased risk of an ACL tear does not appear to be associated with periods of increased laxity in this meta-analysis. Although this suggests that hormonal effects on an ACL tear may not be directly related to increases in knee laxity, the methodologic heterogeneity between published studies limits the conclusions that can be drawn and warrants further investigation.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Enhanced Recovery Technologies for Unconventional Oil Reservoirs
Authors: Thakur Ganesh 
Published: September 2019

Management
Unconventional resources have transformed the landscape of the oil and gas industry. The primary oil recovery factor ranges from 2–8% for the various shale plays throughout the US. Hence, it is imperative to develop the vast potential of unconventional reservoirs and increase the recovery factors beyond primary depletion by implementing IOR/EOR methods. This article describes the role of effective reservoir management and summarizes the detailed review of the advances in IOR/EOR technologies applied to unconventional oil reservoirs, as performed by the Energy Industry Partnership Team (EIP) at the University of Houston (Balasubramanian et al. 2018). That review•included:
A thorough review of the pertinent published literature on IOR/EOR
Results of EOR application to unconventionals shared by various operators in their investor presentations and from press reports
Classifying IOR/EOR studies as laboratory experiments, numerical modeling, and field laboratory trials•(pilots)
Analysis of field trials based on the representative shale plays.
Most studies performed for the application of EOR technologies to unconventional oil reservoirs have been limited to experimental investigations and numerical simulation studies. The research revealed that miscible gas injection (produced field gases, CO2, etc.) is the most promising method among the EOR techniques, including miscible gas, waterflooding, surfactant, chemical, and polymer. Experimental studies showed the following:
CO2 injection had the highest potential of improved recovery in unconventionals followed by produced gas injection. Surfactant injection showed the next best potential to increase oil recovery by altering the wettability of rock in laboratory experiments.
The produced field gas injection pilots showed that sufficient injectivity was achieved mainly due to the injection-induced fractures and did not exhibit any significant effect of diffusion.
Conformance control remains a big challenge due to the channeling of the gas through the fractures.
Produced field gas injection pilots in the Eagle Ford formation have demonstrated the greatest success in increasing oil recovery.
Many inconsistencies exist between laboratory investigations and field trials that need reconciliation and further research to bridge the gap.
This methodical study elicits the learnings and challenges from the application of different IOR/EOR technologies to unconventionals at various scales (micro to macro to field scale). In addition, ideas for future research are recommended to improve the understanding of the complex mechanisms of EOR in unconventional oil reservoirs.
Unconventional resources have changed the landscape of oil and gas industry in the US and the world. Oil production from unconventional tight oil reservoirs have accounted for more than 50% of total oil production in the US in the recent years. Todd et al. reported that unconventional oil reservoirs contributed to more than a 4 million•B/D increase in production between 2011 and•2014.
Maternal effects shape the alternative splicing of parental alleles in reciprocal cross hybrids of Megalobrama amblycephala x Culter alburnus
Authors: Ren Li , Yan Xiaojing , Gao Xin , Cui Jialin , Yan Pengcheng , Wu Chang , Li Wuhui , Liu Shaojun 
Published: September 2019

Abstract
Background
Maternal effects contribute to adaptive significance for shaping various phenotypes of many traits. Potential implications of maternal effects are the cause of expression diversity, but these effects on mRNA expression and alternative splicing (AS) have not been fully elucidated in hybrid animal.

Results
Two reciprocal cross hybrids following hybridization of Megalobrama amblycephala (blunt snout bream, BSB) and Culter alburnus (topmouth culter, TC) were used as a model to investigate maternal effects. In a comparison of BSB and TC homoeolog expression from the two reciprocal cross hybrids, we identified 49–347 differentially expressed BSB-homoeologous genes and 54–354 TC-homoeologous genes. 2402, 2959, and 3418 AS events between the two reciprocal cross hybrids were detected in Illumina data of muscle, liver, and gonads, respectively. Moreover, 21,577 (TC-homoeologs) and 30,007 (BSB-homoeologs) AS events were found in the 20,131 homoeologous gene pairs of TB F3 based on PacBio data, while 30,561 (TC-homoeologs) and 30,305 (BSB-homoeologs) AS events were found in BT F3 homoeologous gene pairs. These results further improve AS prediction at the homoeolog level. To analyze body shape traits, bmpr2a of the bone morphogenetic protein family was selected as an AS model to investigate expression diversity.

Conclusions
The distribution of differentially expressed genes and AS in BSB- and TC-subgenomes exhibited various changes between the two reciprocal cross hybrids, suggesting that maternal effects are the cause of expression diversity. These findings provide a novel insight into mRNA expression changes and AS under maternal effects in lower vertebrates.
Closing the (incarceration) gap
Authors: Shepherd Stephane M , Spivak Benjamin , Ashford Linda , Williams Isabel , Trounson Justin , Paradies Yin 
Published: September 2019

Abstract
Background
“Closing the Gap” is an Australian government strategy that was established to address the inequality in health and education outcomes between Indigenous and non-Indigenous Australians. Although some gains have been realised, progress has been ostensibly slow. One potential obstacle is the large number of Indigenous Australians in prison. 1 in 5 to 1 in 6 Indigenous Australian males are currently imprisoned or have previously been imprisoned. Recent work has also pointed to a widening socio-economic gap within the Indigenous population. Given the myriad social, wellbeing and environmental risk factors associated with justice-involvement, it is conceivable that incarceration may contribute to the increasing disparities found within the Indigenous population. This study aimed to explore the presence and extent of an ‘incarceration gap’ within the Indigenous population and to uncover which social factors characterise the disparity.
Methods
The study utilised data from the 2014-5 National Aboriginal and Torres Strait Islander Social Survey (NATSISS). A number of socio-economic, environmental and clinical factors were compared by life-time incarceration status. Chi-square tests were used to examine the association between incarceration status and each of the comparison variables.
Results
Disparities were observed within the Indigenous Australian population across a number of important health and socio-economic markers by incarceration status - the most pronounced being for educational obtainment, labour force participation and drug/alcohol problems. Never-incarcerated Indigenous males yielded aggregate proportions across numerous variables that approximated or matched general Australian population estimates.
Conclusions
There appears to be evidence for an ‘incarceration gap’ within the Indigenous Australian population. It is evident that the national ‘closing the gap’ strategy necessitates contending with Indigenous over-incarceration.