bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pankreas Kanserinde Progrostik Faktörler
Authors: ÇETİN Şirin , DEDE İsa 
Published: October 2018

Giriş: Bu
çalışmada amaç pankreas kanseri tanısı alan olguların klinik özelliklerinin ve
risk faktörleri ile ilişkisinin retrospektif olarak değerlendirilmesi ve pankreatik
kanserli hastaların yaşam süresini etkileyen prognostik faktörlerin
araştırılmasıdır.Materyal Metot: Çalışmada
pankreas tanısı almış 144 hastanın demografik ve klinik özellikleri incelendi.
Demografik ve klinik özelliklerin sağkalım ile ilişkisini incelemek için
istatistiksel analizler yapıldı. İstatistiksel analizler için SPSS (version 21;
IBM, Armonk, NY) paket programı kullanıldı. Sağkalım eğrilerinin çiziminde
Kaplan-Meier metodu kullanıldı. Prognostik faktörlerin sağkalım analizleri
log-rank testi kullanılarak hesaplandı. 95% güven aralığı sağkalım zamanı ve
her bir prognostik faktör arasındaki ilişkiyi belirtmek için kullanıldı. Bulgular: Pankreatik
kanserli 144 hastanın ortanca sağkalım
süresi 11 ay (%95 CI 8.92-13.07) olarak bulundu. Cox regresyon analizi
sonucunda yaş, diyabet, kilo kaybı ve alkol kullanımının pankreatik kanserli
hastalarda sağkalımla ilişkilerinin
anlamlı olduğu saptandı.

Sonuç ve Tartışma:
Çalışmamızda pankreas kanserli hastaların sağkalım süresini etkileyen prognostik
faktörlerin etkisi değerlendirilmiştir.
Teaching philosophy in practice: Developing compatibility through personal practical knowledge
Authors: Kumagai Kazuaki , Black Laurel Johnson 
Published: October 2018

As part of an MATESOL mentoring program, developing educators were paired with experienced professors. The authors explore how personal practical knowledge bridges the gap between teaching philosophy and classroom practice. The complex layers of experience and knowledge that a mentor can offer need to be prompted, however; they cannot simply be deduced by observing. Using observational notes, interviews, and reflection, we explore real-time teaching decisions as a way to elaborate and reconsider the usually succinct teaching philosophy statement. This is particularly important for new teachers and those who are teaching in contexts or with students whose culture is still being absorbed. Personal practice knowledge is seen as the stem from which both teaching philosophy and classroom practice bloom.
Age-related aspects of differential diagnosis of acute cough in children and adults
Authors: Leshchenko I. V. , Tsar’kova S. A. , Zherebtsov A. D. 
Published: October 2018

Cough is one of the most common causes of seeking the primary medical care, especially during the autumn and the spring. This article is a review of literature aimed at differential diagnosis of possible causes of acute cough in children and adults. Given a vast majority of diseases associated with cough, differential diagnosis have to consider several issues. The key issue is cough duration and possible anatomical location of the pathological changes. An algorithm of differential diagnosis of acute cough in children and adults and description of most common diseases associated with acute cough are given in the review. Further diagnostic work-up should be driven by the duration of cough as soon as the acute cough could be first manifestation of a chronic disease.
Acute exacerbation of idiopathic pulmonary fibrosis
Authors: Avdeev S. N. 
Published: October 2018

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is defined as an acute clinically significant respiratory deterioration characterized by evidence of new, widespread alveolar abnormalities, such as diffuse bilateral ground-glass opacification and/or consolidation, and the absence of other obvious clinical causes like fluid overload, left heart failure, or pulmonary embolism, etc. AE-IPF is subcategorized as “triggered” (where specific causes are identified, for example, infections, surgery procedures, drug toxicity, etc.) or “idiopathic” (where no specific causes are identified). In randomized trials, the annual incidence of AE-IPF is about 8%, in retrospective studies it reaches 19%. Severe forms of IPF are an important risk factor for the development of AE-IPF. In-hospital mortality from AE-IPF is more than 50%, and the average survival of patients with AE-IPF is 1–4 months. Currently, there remain no proven, effective therapies for AE-IPF. In real clinical practice patients with AE-IPF still receive high doses of systemic corticosteroids and antibiotics. Antifibrotic therapy can reduce the risk of exacerbations; it has been shown that therapy with nintedanib leads to a reduction in the number of confirmed/suspected AE-IPF by 68%. It is necessary to further study the potential methods of prevention and therapy of AE-IPF in future clinical trials.
APRESENTAÇÃO: EDUCAÇÃO, GÊNERO E TRABALHO EM DEBATES
Authors: Araújo Wagner dos Reis Marques , Andrade Roberta Ferreira Coelho de , Andrade Aldair Oliveira de , Siqueira Antonio Marcos de Oliveira 
Published: October 2018

Neste volume compartilhamos discussões que contemplam abordagens acerca das temáticas educação, gênero e trabalho, onde os/as autores/as trazem suas preocupações com essas dimensões que permeiam a vida em sociedade. A despeito de termos organizado as discussões em seções temáticas, o recorte epistemológico que norteou a edição confirma a intersecção entre as três dimensões destacadas na organização que vos apresentamos. Educação, gênero e trabalho. Encerramos mais este número do volume 1 da Revista Relações Sociais, apresentando como nas edições anteriores, artigos e resumos de teses e dissertações de temas que interessam a quem volta o olhar epistemológico para os estudos da sociedade com base nas categorias trabalho, gênero e educação.
CURSO PRÉ-VESTIBULAR UNIVERSIDADE PARA TODOS: CONTRIBUIÇÕES PARA O ACESSO DE ESTUDANTES AO ENSINO SUPERIOR E AO MERCADO DE TRABALHO
Authors: Sousa Erivan Coqueiro , Nunes Claudio Pinto , Sousa Gilvan dos Santos 
Published: October 2018

Este trabalho analisa as contribuições do curso pré-vestibular Universidade Para Todos (UPT) para o acesso de jovens ao Ensino Superior. Explana-se sobre a ausência de perspectivas dos estudantes egressos do Ensino Médio no que tange este nível educacional e o baixo grau de instrução dos pais para orientarem os filhos. Salienta-se a importância do curso de nível superior para o enriquecimento intelectual e possibilitar melhores postos no mercado de trabalho. Segue-se a perspectiva metodológica de revisão bibliográfica sobre o tema evidenciado e a análise de entrevistas realizadas com 25 (vinte e cinco) ex-alunos do curso UPT, em Aracatu, Bahia. Os resultados evidenciam que a maioria dos entrevistados opta por cursos de nível superior relacionados a licenciaturas, justificam as escolhas na distância geográfica da universidade, já que é mais viável realizar um curso mais próximo da residência, devido à condição socioeconômica. O curso foi avaliado como excelente ou bom, visto que auxiliou nos vestibulares realizados. Deve-se ter pontualidade na entrega dos materiais didáticos. É perceptível que o curso UPT, mesmo com problemas estruturais, contribuiu para que estes estudantes conseguissem acesso ao ensino superior e ao mercado de trabalho.
İnsan İnsülin Hormonu Öncülerinin Pichia pastoris AOX1 Promotoru Altında Klonlanması, Ekspresyonu ve Biyoreaktörde Üretimi
Authors: Türkanoğlu Özçelik Aysun , Torun Ayşe , Yılmaz Semiramis , İnan Mehmet 
Published: October 2018

İnsülin
pankreasın beta hücrelerinden üretilen ve vücutta glukoz dengesini sağlayan
önemli bir peptit hormondur. Pankreasın yeterli miktarda insülin üretememesi ya
da hücrelerin üretilen insüline cevap verememesi sonucu kan glukoz düzeyinin
yükselmesiyle diyabet adı verilen metabolik bir hastalık meydana gelir.
Günümüzde bu hastalığın tedavisinde insülin hormonu kullanılmaktadır. İnsülin
hormonu genetik mühendisliği teknikleri kullanılarak rekombinant olarak
üretilen ilk proteindir. İlk olarak Escherichia
coli ve Saccharomyces cerevisiae’da üretilmeye başlanmış, ancak son zamanlarda rekombinant insülin üretiminde Pichia pastoris (Komagataella phaffi) ’in &nbsp;kullanımı
yaygınlaşmıştır. Bu çalışmada, insan insülin hormonu öncülerinin (IP) P. pastoris’in metanol ile
indüklenebilir AOX1 promotoru altında
üretimini sağlamak amacıyla; bu proteini kodlayan DNA fragmenti transformasyon
ve ligasyon gibi moleküler biyoloji teknikleri kullanılarak plazmide aktarılarak
istenen proteini kodlayan bir ekspresyon vektörü elde edilmiştir. Ekspresyon
vektörünün lityum asetat yöntemiyle yetenekli hale getirilen P. pastoris X33 suşuna elektroporasyonla
transferi sağlanmıştır. 5L ölçekli biyoreaktörde yapılan protein ekspresyonu
çalışması sonrasında alınan örnekler SDS-PAGE ve ELISA yöntemleriyle analiz
edilmiş ve 7.5 mg/L IP proteini üretildiği tespit edilmiştir.
Simulation analysis of resource-based city development based on system dynamics: A case study of Panzhihua
Authors: Qin Yong , Luo Yuyan , Lu Jingru , Yin Lu , Yu Xinran 
Published: October 2018

Abstract
Resources and the environment have always been the two important natural factors that affect people’s lives. In recent years, the problem of resources and the environment has increasingly become an important issue that people are concerned about. This study discusses the use and consumption of energy and the impact of environmental pollution on economic development under sustainable economic development. This paper takes Panzhihua as an example to analyze the impact of energy and environment on the economy, and proposes solutions to improve economic development, which is of strategic significance for the future development of Panzhihua City. In this paper, the system dynamics method is used to decompose the Panzhihua large-scale system into three parts and carry out modeling and simulation to explore the connection between them. Based on the data from 2007 to 2015 in Panzhihua City, simulations have been carried out to obtain qualitative and quantitative analysis of certain simulation curves of the energy-environment-economy 3E system (hereinafter referred to as 3E system) from 2007 to 2030 to ascertain the future development pattern of Panzhihua City. The results show that when the 3E system is a coordinated development model, economic development and environmental protection have a good development trend at the same time, which is applicable to the future development of Panzhihua City. This model has good reference suggestions and application prospects for urban development. We want to give Panzhihua City the following suggestions: (1) Continue to focus on the secondary industry and increase competitiveness. (2) Increase the investment funds in environmental protection and achieve sustainable economic development.
A new computational algorithm for the solution of second order initial value problems
in ordinary differential equations
Authors: Pandey P.K. 
Published: October 2018

Abstract
In this article, we propose a new computational method for second order initial value problems in
ordinary differential equations. The algorithm developed is based on a local representation of theoretical solution of the second order initial value problem by a non-linear interpolating function. Numerical examples are solved to ensure the computational performance of the algorithm for both linear and non-linear initial value problems. From the results we obtained, the algorithm can be said computationally efficient and effective.
Effects of second-order slip and drag reduction in boundary layer flows
Authors: Vajravelu Kuppalapalle , Li Ronald , Dewasurendra Mangalagama , Benarroch Joseph , Ossi Nicholas , Zhang Ying , Sammarco Michael , Prasad K.V. 
Published: October 2018

Abstract
In this paper, boundary layer flow over a moving flat plate with second-order velocity slip, injection and applied magnetic field is analyzed. The governing partial differential equations are converted in to a nonlinear ordinary differential equation through an appropriate similarity transformation. The resulting nonlinear equation is solved via homotopy analysis method (HAM). Errors ranging from 10–7 to 10–10 are reported for a relatively few terms. The effects of the pertinent parameters on the velocity and the shear stress are presented graphically and discussed. In the absence of magnetic field and the two slip parameters, the results are found to be in excellent agreement with the available results in the literature. It is expected that the results obtained will not only provide useful information for industrial applications but also complement the earlier works.
A Coreflooding-NMR Study of Gel Conformance Control in Fractured Systems
Authors: Alshehri Amar J. , Wang Jinxun , Kwak Hyung T. , AlSofi Abdulkarim M. 
Published: October 2018

Abstract
Conformance control using polymer gels has been successfully used in both sandstone and carbonate reservoirs to improve sweep efficiency. A challenge in achieving successful gel placement away from the well is reservoir high temperature. In such envrionments, a thourgh understanding of the gel system and its behavior in heterogenous reservoirs along with enhancing its performance is essential for a proper gel placement.
In this work, several coreflood experiments were conducted to assess the performance of polyacrylamide/chromium gel system in a high-temperature and high-salinity (HTHS) carbonate cores. The used cores were specially prepared with different configurations of high-permeability channels surrouned by rock matrix. The gel treatment was performed in a tertiary mode, and soaked at reservoir temperature for gelation, then followed by chase waterflooding. Nuclear magnetic resonance (NMR) techniques were used to monitor oil distribution throughout the coreflood experiments and determine sweep improvement due to the gel treatment. To improve the contrast between oil and brine/gel in NMR measurements, heavy water (D2O) was used as the aquous phase.
Results show that unrecovered oil in the matrix was effectively displaced after the gel treatment. This improvement could be attributed to viscous effects and/or fluid-diversion effects. Hence, a similar experiment was conducted using only polyacrylamide solutions (chromium crosslinker was not added) to quantify improvement due to viscous effects only.
This work demonstrates the potential of the studied gel system and its favorable impact on sweep efficiency improvement in HTHS carbonates. The NMR study shows how gel helps improve sweep efficiency of subsequent floods through blocking/reducing the permeability of highly-conductive zones. Moreover, a better understanding is achieved through proper attribution of viscous effects and fluid- diversion effects on improvement in oil displacement for gel treatments. It was found out that improvement in oil production due to viscous effects was very small compared to blockage or fluid- diversion effects.
Programar computadoras en Educación Infantil
Authors: Martinez María Cecilia , Gomez Marcos Javier 
Published: October 2018

Este artículo analiza una experiencia de enseñanza de la programación con robots en un centro de educación infantil. Basándonos en observaciones, trabajos prácticos de los alumnos y grupos focales; identificamos que los niños logran construir ideas complejas sobre qué es una computadora, qué es programar y qué hace un programador. La programación de robots con lenguaje icónico también permite desarrollar conceptos computacionales como secuencia, parámetro, ciclo y condicional. Los niños de 5 años establecen correspondencia entre el código programado por ellos y el desplazamiento de los robots, apropiándose de la noción de computadora como máquina programable. Los pequeños de 3 y 4 años no logran comprender esta idea.
Gastroduodenal Disorders in Patients with CVID Undergoing Immunoglobulin Therapy
Authors: Varricchi Gilda , Pecoraro Antonio , Crescenzi Ludovica , Marone Giancarlo , Travaglino Antonio , D'Armiento Francesco Paolo , Genovese Arturo , Spadaro Giuseppe 
Published: October 2018

Background:
Common variable immunodeficiency (CVID) encompasses a heterogeneous
group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity
and malignancies. Gastrointestinal manifestations are frequently associated with CVID.

Objective:

In this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of
adult patients with CVID.

Methods:

Upper gastrointestinal endoscopy was performed in 58 patients (26 males, mean age 47.8±15.6
years), diagnosed with CVID according to 2014 ESID criteria. Random biopsies were collected from gastric
antrum and descending duodenum for the all enrolled subjects. Intraepithelial lymphocytosis in descending
duodenum was defined as the presence of 25 lymphocytes per 100 enterocytes.

Results:

The major histopathological findings that we found were: a) chronic active gastritis (44.8%),
Helicobacter pylori-associated (8.6%), b) chronic duodenitis (39.6%) with intraepithelial lymphocytosis
(31%) and absence of plasma cells (18.9%) and c) autoimmune atrophic gastritis (5.2%). Three patients
(5.2%) presented Intestinal Metaplasia (IM) of the gastric antrum. This finding was associated
with H. pylori infection and persisted after the eradication in one patient. IM was associated with autoimmune
atrophic gastritis in two cases. Giardia lamblia infection was observed in the duodenum samples
from three patients (5.2%). A diagnosis of Gastric adenocarcinoma was made in a 58-year- old
woman diagnosed with gastric dysplasia one year earlier.

Conclusion: In our cohort of CVID patients, gastro-duodenal histopathological findings, including malignancies,
are frequent and can affect long-term prognosis. A rigorous endoscopic follow-up is needed
in CVID patients irrespective of the gastrointestinal symptoms.
Correlation of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide- like 3G Genetic Variant rs8177832 with HIV-1 Predisposition in Pakistani Population
Authors: Iqbal Khurshid , Imran Muhammad , Ullah Shafi , Jamal Muhsin , Waheed Yasir 
Published: October 2018

Background:
Human immunodeficiency virus (HIV) infection is a global health burden
which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host
factors which are capable of limiting HIV-1 replication. One of the most important host factors
which inhibit HIV-1 DNA synthesis is the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-
like 3G (APOBEC3G). Any genetic variation of this important host factor may influence the
host susceptibility to viral infection.

Objective:
The aim of the current study was to evaluate any correlation of APOBEC3G genetic
variation rs8177832 with HIV-1 infection.

Methods:
The study involved 142 healthy control and 100 HIV-1 infected subjects. The genetic
variation rs8177832 of all studied subjects was determined by allele-specific polymerase chain reaction
(AS-PCR).

Results:
The results showed that the distribution of rs8177832 genotypes AA, AG and GG in
healthy subjects and HIV-1 subjects was; 42.253%, 42.957%, 14.788% and 66%, 27%, 7% respectively.
Statistical analyses of data showed that there was a significant variation in rs8177832 genotype
AA in healthy control and HIV-1 infected subjects (42.257% vs 66%; p-value<0.001).

Conclusion:
Thus it was concluded that APOBEC3G rs8177832 AA genotype contributes in genetic
predisposition to HIV-1 infection in Pakistani population.
Lärares lek och barns arbete
Authors: Botö Kerstin , Lantz-Andersson Annika , Wallerstedt Cecilia 
Published: October 2018

The study emanates from the practice at the inter-section between subject-oriented activities and play in a preschool class. The focus on children’s early literacy development is grounded in two views: the bottom-up or phonics perspective (reading and writing primarily as a skill) and the top-down or whole language perspective (communicative function and meaning of written language). The aim is to explore how literacy activities are performed in a preschool class, specifically, how teachers and children interact in a literary activity where an educational TV-program is used as a teaching tool. Theoretically, the study is underpinned by a socio-cultural perspective on learning, and the data is comprised of video recordings of the classroom activities. The analysis focuses on how the interaction is framed by institutionally based perspectives on both learning and play. The results show that play is introduced in the activities, but becomes transformed into an interaction pattern akin to schooling, in which the phonicstradition takes precedence. The teachers solve the dilemma between play and work by framing the activity in a playful way, inspired by the TV-program, while the children’s work develops into accomplishing a task. Keywords: preschool class, early literacy development, educational television program, teacher-child interaction, play
Disturbing Behaviours: Ole Ivar Lovaas and the Queer History of Autism Science
Authors: Gibson Margaret F. , Douglas Patty 
Published: October 2018

This paper “queers” the history of autism science through an examination of the overlap between the regulation of autism with that of gender and sexuality in the work of Ole Ivar Lovaas. Lovaas is the founder of Applied Behaviour Analysis (ABA), the most commonly used and funded autism intervention today that seeks to extinguish autistic behaviors, primarily among children. Less commonly recognized is Lovaas’ involvement in the Feminine Boy Project, where he developed interventions into the gender identities and behaviors of young people. Turning to Lovaas’ published works, we perform a “history of the present” and argue that a queer disability studies lens opens up the richness of autism as a cultural nexus, and deepens understandings of intersecting and contested histories of science, professional scopes of practice, and dominant futurities. The article makes a significant and timely contribution to understanding the disabling material effects of autism science in the lives of autistic persons. In particular, this case study highlights the need for feminist science studies to further investigate the historical and contemporary links between dominant scientific constructions of disability, gender, and sexuality.
Implementasi Analisis NIDS Berbasis Snort Dengan Metode Fuzy Untuk Mengatasi Serangan LoRaWAN
Authors: Sandi Della Vinka , Arrofiq Muhammad 
Published: October 2018

Indonesia merupakan salah satu negara agraris dengan kondisi tanah yang sangat subur, tetapi perlu diketahui bahwa hasil dari pertanian saat ini belum maksimal di beberapa daerah, seperti halnya pada perkebunan stroberi. Tanaman stroberi sendiri membutuhkan tingkat suhu dan kelembaban udara yang tepat, agar hasil panen stroberi lebih maksimal. Kelembaban tanah dan suhu udara sering kali berubah tergantung cuaca, untuk itu penelitian ini akan membuat suatu alat atau portotipe yang disebut Smart Agriculture untuk melakukan monitoring suhu dan kelembaban tanah pada perkebunan stroberi. Data suhu dan kelembaban tanah akan dikirimkan melalui media transmisi nirkabel menuju ke smartphone menggunakan LoRa dan teknologi LoRaWAN. Teknologi ini mampu mengirimkan data dalam jarak yang cukup jauh, namun server rentan terhadap serangan seperti flooding payload data dari LoRa node, ping flooding dan scanning port. Pada penelitian ini menerapkan serangan itu pada LoRaWAN network server yang berpengaruh pada Bandwidth, Delay, Jitter dan Throughput dari kondisi normal. Untuk melakukan deteksi serangan diimplementasikan metode Snort NIDS dan pengelompokan tindakan serangan (low, medium, high) dengan metode fuzzy logic. Hasil dari penelitian ini adalah berupa tindakan berupa pembacaan suhu dan kelembaban, notifikasi serangan dan blok alamat attacker. Selain itu dapat dibuktikan bahwa dengan adanya fuzzy dan snort mampu mengoptimalkan performa server.