bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency and Association of Polymorphisms in F2, F7, and PROS1 Coagulation Genes with Disease Severity in Coronavirus Disease 2019
Authors: Alshaya Dalal Sulaiman , Alzamil Lama A. , Alghamdi Alanoud S. , Alshammari Lolwah S. , Alhowaiti Saltana A. , Bohol Marie Fe F. , Abudouleh Esra’a , Alhamlan Fatimah , Al-Qahtani Arwa A. , Al Hazzani Amal , Owaidah Tarek , Al-Qahtani Ahmed A. 
Published: November 2024

Abnormal transcriptomic profiles of coagulation genes have been linked to coagulopathies in patients with coronavirus disease 2019 (COVID-19). The objective of the present study was to explore the frequency of genotypes and potential association of polymorphisms in genes encoding coagulation factors with the disease severity in COVID-19 patients.The patients were clinically categorized into four groups of COVID-19 disease severity (asymptomatic, mild, moderate, and severe). Three variants of genes, involving the coagulation genes rs3136516 (F2 gene), rs6042 (F7 gene), and rs6123 (PROS1 gene), were studied. Polymorphisms were genotyped by Sanger DNA sequencing.Most of the subjects had moderate COVID-19 infection (n = 53, 62.4%), followed by mild (n = 16, 18.8%), and severe infections (n = 15, 17.6%). The frequency of the rs3136516 AG genotype was considerably higher in non-ICU patients compared to ICU patients (51.3% vs 34.1%, OR 3.167, 95% CI 1.094-9.170, P = .031). Furthermore, the dominant genetic model (AA + AG vs GG) was significantly associated with a decreased probability of admission to the ICU in COVID-19 patients (OR 0.340, 95% CI 0.127 - 0.905, and P = .028). No other variants of the coagulation genes studied were found to be associated with the severity of COVID-19 disease, admission to the ICU, and mortality ( P > .05).The rs3136516 AG genotype could predispose COVID-19 patients to increased disease severity and therefore admission to the ICU, while the dominant genetic model (AA + AG vs GG) of rs3136516 exerts a protective role.
Seeing it in others versus doing it yourself: Social desirability judgements and conversation production data from autistic and non-autistic children
Authors: McGuinness Lauren , Abbot-Smith Kirsten , Gambi Chiara 
Published: November 2024

On average, groups of autistic individuals are more likely than groups of non-autistic individuals to exhibit unconventional conversational behaviours. We examined autistic and non-autistic children’s social impressions of unconventional responding, as well as actual conversational behaviours in the same participants. Across two studies, 36 autistic and 36 non-autistic matched 9–13-year-olds listened to conversational vignettes which manipulated the relevance and timing of responses produced by the speaker. They then rated the speaker’s social desirability. We also measured the content and latency of the same children’s conversational responses. Autistic children aligned with their non-autistic peers in indicating that they were less likely to befriend, or enjoy interacting with, a speaker who provided off-topic or delayed responses. However, the same autistic children provided more off-topic, and fewer topic-continuing, conversational responses than their non-autistic counterparts. These findings suggest that displaying unconventional conversational behaviours may act as a barrier to friendship or inclusion for autistic children, even when socialising with other autistic peers. Lay abstract During a conversation, on average, autistic individuals are often more likely than non-autistic people to provide an off-topic comment and/or to pause for longer before providing a response. One possible explanation for this is that autistic individuals prefer, or are more tolerant of, unconventional communication styles. To explore this possibility, we investigated whether autistic and non-autistic 9–13-year-olds find off-topic or delayed responding a deterrent to friendship or interaction. Participants listened to scripted conversations and then rated social desirability statements, such as ‘I would enjoy chatting to the [target speaker]’. We also examined the prevalence of these behaviours in children’s own conversational responses. We found that autistic children were just as likely as non-autistic children to dis-prefer unconventional conversational responding. Both groups indicated that they were less likely to want to be friends with the speaker, or to chat with them, when they provided off-topic or delayed responses. However, despite their judgements of others, the same autistic children were more likely to provide off-topic responses themselves than their non-autistic peers, as well as giving fewer on-topic responses which facilitate back-and-forth conversation. Overall, this is problematic for autistic children, as our findings suggest that the tendency to exhibit unconventional conversational behaviours will have negative social consequences, even when interacting with other autistic peers.
Frequency and Characteristics of Integrative Oncology Referrals for Patients With Cancer Receiving Inpatient Rehabilitation
Authors: Gupta Ekta , Lopez Gabriel , Narayanan Santhosshi , Tennison Jegy M. , Elahi Imran , Rozman de Moraes Aline , Fellman Bryan M. , Bruera Eduardo 
Published: November 2024

Background: Integrative Oncology (IO) interventions may decrease physical, psychological, and social distress related to cancer and its treatments. Little is known about the frequency and predictors of IO referral for symptom management for cancer rehabilitation inpatients. Methods: A retrospective review was performed of patients with cancer who underwent inpatient rehabilitation at a specialized tertiary cancer center from 5/2016 to 3/2020. Patient demographics and IO consultation details, including patient-reported outcome measures of symptom burden using ESAS-FS and functional status using the Activity Measure for Post-Acute Care “6 clicks,” were extracted. Descriptive summary statistics and logistic regression were used to analyze the data. Results: Out of 1196 inpatient rehabilitation admissions, 100 (8.4%) were referred to IO. The Activity Measure for Post-Acute Care “6 clicks” basic mobility admission scores were significant at a 1-point difference between the intervention and control group (39.5 vs 40.8, P < .05); both scores equate to a ˃50% degree of functional impairment. Referred patients were younger (62, P = .02) and Hispanics or Latinos ( P = .02). The top symptoms for IO consultation included pain (N = 73), integrative approach (N = 41), relaxation (N = 38), and stress/anxiety (N = 33). Patients who reported a baseline symptom score ≥ 1 in the ESAS-FS, had both statistically ( P < .05) and clinically significant improvements (≥1 point change) for pain, fatigue, well-being, anxiety, and sleep after massage therapy. Conclusion: Cancer rehabilitation inpatients were commonly referred to IO to address pain, with observed improvements across multiple symptoms with massage therapy. Lower mobility scores and younger patients received significantly higher referrals to IO. Larger trials are needed to characterize the effects of IO interventions on the inpatient rehabilitation of patients with cancer.
Roles Caregivers Take on in Pediatric Rehabilitation Telehealth Services: A Scoping Review
Authors: Tkach Melanie Morriss , Earwood Juliana Hudson 
Published: November 2024

Background: Caregivers and children continue to use pediatric rehabilitation telehealth services (PRTS) post-pandemic. Understanding how caregivers support children during PRTS can help us fully integrate caregivers for positive outcomes. This scoping review describes the roles caregivers take on during PRTS. Methods: We searched MEDLINE, CINAHL, PsycINFO, and ERIC for research published January 2005 to July 2023. We included English articles on the effect of PRTS. We excluded qualitative and non–peer-reviewed literature. Results: Thirty-four articles met inclusion criteria. Caregivers were gatekeepers, technicians, implementers, trainees, collaborators, telehealth consumers, and supervisors in PRTS. Caregivers took on roles throughout PRTS, and roles varied by type of PRTS delivered. Conclusions: Caregivers take on multiple roles to support children during PRTS. Our results can inform clinical decisions about how to integrate and support caregivers in PRTS. Future research should explore strategies that support caregiver role taking to maximize caregiver involvement and outcomes in PRTS.
Changes in the Elongation Pattern of the Medial Collateral Ligament During a Single-Leg Squat After Anterior Cruciate Ligament Reconstruction
Authors: Agostinone Piero , Di Paolo Stefano , Lucidi Gian Andrea , Marchiori Gregorio , Bontempi Marco , Bragonzoni Laura , Davidoni Vittorio , Grassi Alberto , Zaffagnini Stefano 
Published: November 2024

Background: An anterior cruciate ligament (ACL) tear impairs knee biomechanics in daily activities and potentially breaks the synergy among other knee ligaments. Previous studies have demonstrated that the biomechanics of collateral ligaments is influenced by ACL deficiency. Purpose: To investigate changes in the elongation patterns of the medial collateral ligament (MCL), lateral collateral ligament (LCL), and posterior cruciate ligament (PCL) during the execution of a single-leg squat before and after ACL reconstruction. Study Design: Descriptive laboratory study. Methods: A total of 16 patients (mean age, 24.9 ± 8.5 years) with ACL deficiency were enrolled in the study. Magnetic resonance imaging scans of the affected knees were used to produce 3-dimensional models of the tibia and femur and identify insertion sites of the MCL, LCL, and PCL. Motion capture of a single-leg squat was performed through a biplanar radiographic system. Data were acquired before ACL reconstruction and at a minimum of 18 months (mean, 22.9 ± 4.1 months) postoperatively. The centroids of the ligaments’ insertions were used to calculate the length of the investigated structures during the squat task. Absolute length ( L), absolute length increase from the orthostatic resting position (Δ L), and relative length increase (Δ L%) were computed for each ligament, and preoperative and postoperative data were compared using the paired Student t test. The intraclass correlation coefficient was used to determine the reliability of the ligament insertion's identification and kinematics between 2 independent observers. Results: Significant differences were found for the MCL in absolute length increase ( P = .047; Cohen d = 0.60) and relative length increase ( P = .043; Cohen d = 0.61) from rest between preoperatively and postoperatively (Δ Lpre = 1.0 mm; Δ Lpost = −1.1 mm; difference = 2.1 mm) at 0° to 30° of knee flexion during the descending phase of the single-leg squat. No differences were seen in the elongation patterns of the LCL or PCL from before to after ACL reconstruction. Conclusion: The MCL was significantly longer between 0° and 30° in ACL-deficient knees compared with ACL-reconstructed knees during the descending phase of a single-leg squat. No differences were identified for the LCL or PCL. Clinical Relevance: Early ACL reconstruction could have a protective effect on the MCL in combined ACL and MCL lesions.
Understanding the Relationship Between Critical Care Nurses’ Perception of Patient Safety Culture and Adverse Events
Authors: Alkubati Sameer A. , Al-Qalah Talal , Salameh Basma , Alsabri Mohammed , Alrubaiee Gamil Ghaleb , Loutfy Ahmed , Alwesabi Sadeq A. , El-Monshed Ahmed H. , Elsayed Shimmaa M. 
Published: November 2024

Background Establishing a positive safety-culture environment is essential in healthcare settings to enhance patient care. This study aimed to determine the relationship between critical care nurses’ perceptions of patient safety culture and adverse events. Methods A cross-sectional study was conducted among 200 nurses working in critical care units in the Damanhour Governorate in Egypt. Data were collected using a self-administered questionnaire, including the Hospital Survey of Patients’ Safety Culture (HSOPSC) and information on adverse events (AEs). Results The study revealed areas for improvement in patient safety culture, with low positive response rates in staffing (26.6%), non-punitive response to errors (38%), handoffs and transitions (39.4%), teamwork across and within units (42.3%), and overall perception of patient safety (49.3%). The majority of critical care nurses had a moderate to high level of overall perception of patient safety at 42.5% and 42.0%, respectively. The most frequent adverse events reported daily were complaints from patients or their families (65.5%). Adverse drug events and patient falls occurred several times per week in 56.5% and 57.0% of patients, respectively. A significant association was found between low safety culture perception and higher rates of patient falls ( p = .008), adverse drug events (p = .005), and patient/family complaints (p = .030). Conclusion The findings of the study indicate that nurses’ perceptions of patient safety culture are moderate. Adverse medication responses, falls, and complaints from patients or their families were noted. Female nurses aged 31 to 40, especially divorced nurses, had more experience, worked fewer than 8 h daily, and had a higher education level, which appeared to influence overall safety culture perceptions. Furthermore, there was a correlation between the prevalence of adverse events and patient safety culture, with cooperation being the key factor.
Are viral loads in the febrile phase a predictive factor of dengue disease severity?
Authors: Dayarathna Shashika , Kuruppu Heshan , Silva Tehani , Gomes Laksiri , Shyamali N. L. Ajantha , Jeewandara Chandima , Ariyaratne Dinuka , Ramu Shyrar Tanussiya , Wijewickrama Ananda , Ogg Graham S. , Malavige Gathsaurie Neelika 
Published: November 2024

Abstract
Background
As many studies have shown conflicting results regarding the extent of viraemia and clinical disease severity, we sought to investigate if viraemia during early dengue illness is associated with subsequent clinical disease severity.

Methods
Realtime PCR was carried out to identify the dengue virus (DENV serotype), in 362 patients, presenting within the first 4 days of illness, from 2017 to 2022, in Colombo Sri Lanka. To characterize subsequent clinical disease severity, all patients were followed throughout their illness daily and disease severity classified according to WHO 1997 and 2009 disease classification.

Results
263 patients had DF, 99 progressed to develop DHF, and 15/99 with DHF developed shock (DSS). Although the viral loads were higher in the febrile phase in patients who progressed to develop DHF than in patients with DF this was not significant (p = 0.5). Significant differences were observed in viral loads in patients infected with different DENV serotypes (p = 0.0009), with lowest viral loads detected in DENV2 and the highest viral loads in DENV3. Sub-analysis for association of viraemia with disease severity for each DENV serotype was again not significant. Although those infected with DENV2 had lower viral loads, infection with DENV2 was significantly associated with a higher risk of developing DHF (p = 0.011, Odds ratio 1.9; 95% CI 1.164 to 3.078). Based on the WHO 2009 disease classification, 233 had dengue with warning signs (DWW), 114 dengue without warning signs (DWoWS), and 15 had severe dengue (SD). No significant difference was observed in the viral loads between those with SD, DWW and DWoWS (p = 0.27).

Conclusions
Viral loads were significantly different in the febrile phase between different DENV serotypes, and do not appear to significantly associate with subsequent clinical disease severity in a large Sri Lankan cohort.
Continuous work-related sitting time and its association with perceived workplace support for health among workers in the Greater Accra Municipality: a cross-sectional analysis with sensitivity analyses
Authors: Danquah Emelia , Asiamah Nestor 
Published: November 2024

Abstract
Background
Research to date has shown that work-related sitting time can be a major occupational health risk. This understanding has encouraged several workplace health promotion efforts. Even so, some domains of work-related sitting time and their associations with Perceived Workplace Support for Health (PWSH) have not been considered in research. This study aims to compare domains of work-related sitting time between employee characteristics (e.g., gender and age) and assess their associations with PWSH.

Methods
This study adopted a cross-sectional design with a sensitivity analysis against confounding and measures against common methods bias. The study population was employees of private and public firms in Accra, Ghana. In all, 1000 employees participated in the study. The hierarchical linear regression analysis and the independent samples t-test were used to present the results.

Results
Employees working in service firms, compared with those working in manufacturing firms, reported longer sitting time for lunchtime. After adjusting for physical function, we found a negative association between PWSH and the sum of continuous sitting time as well as its domains (p < 0.001), except for ‘sitting with a desk’ (p > 0.05).

Conclusion
Work-related sitting time was associated with employee characteristics and was lower at higher PWSH. This study reinforces the importance of workplace support for health and its role in work-related sitting.
Reflections on timing of motherhood - a qualitative online study with women of reproductive age
Authors: Temmesen Camilla Gry , Nielsen Henriette Svarre , Birch Petersen Kathrine , Clemensen Jane 
Published: November 2024

Abstract
Background
The age of Danish women giving birth to their first child has risen throughout the last 50 years, and the number of women and men who are having their first child when they are at advanced maternal or paternal age is increasing worldwide. Postponing parenthood is not unique to Denmark, as the same pattern is seen especially in other European and Western countries. The aim of this study was in a social media setting to explore reflections on the timing of motherhood among Danish women of reproductive age who not yet had children.

Method
This study was a qualitative study based on three online focus groups on Facebook. Twenty-six women of reproductive age discussed the timing of motherhood for three days in January 2020. Data were analyzed using Systematic Text Condensation.

Results
Three main themes were identified: ‘Life before parenthood’, ‘To plan for a child’ and ‘A life without children’. Several external and internal conditions influence whether and if so when women consider becoming mothers. Regarding the biological capacity for having children, women compare themselves with their female relatives and friends and colleagues regarding the social norms surrounding motherhood. Women with no children often experience either positive or negative pressure from family, friends, and colleagues regarding when to have children.

Conclusion
Several internal and external considerations influence when and if women become mothers. Social surroundings such as family, friends, and colleagues have an impact on women’s reproductive considerations in terms of pressure to have children in the future. Danish women tend to compare their reproductive capacity to their female relatives and compare the social norms surrounding motherhood to their female friends. Women in this study were positive towards discussing the timing of motherhood with other women of reproductive age on social media.
Compulsory treatment at home: an interview study exploring the experiences of an early group of patients, relatives and mental-health workers
Authors: de Waardt D. A. , de Jong I. C. , Lubben M. , Haakma I. , Mulder C. L. , Widdershoven G. A. M. 
Published: November 2024

Abstract
Background
When introduced in 2020, the Netherlands’ Compulsory Mental Healthcare Act included provisions for compulsory community treatment (CCT) and compulsory treatment in patients’ homes (CTH). Although CCT has been incorporated into mental health care in many countries, its effectiveness is debated. We know of no other countries in which CTH has been adopted.
The aim of this study is to evaluate how an early group of participants experienced CTH. They were drawn from three stakeholder groups: patients, relatives and mental-health workers.

Methods
In total, 17 open interviews were conducted with six patients, five relatives and six mental-health workers. All had experience with CTH. Thematic analysis was used to analyze the interviews.

Results
Five themes were identified: 1). Reasons for applying for a court order with options for CTH. The reasons included preventing harm, avoiding hospitalization, and providing a safety net. 2.) Participants’ experiences with CTH in practice. The four most noteworthy experiences were related to the process of applying for a court order; compulsory home visits and the compulsory use of medication; the involvement of relatives during treatment; and the influence of CTH on the relationship between patients and relatives. 3.) The advantages and disadvantages of CTH. The most important advantages were avoiding hospitalization; improving medication adherence; facilitating easy access to care; early signaling of deterioration; early intervention; and regained autonomy. The most important disadvantages were restricted autonomy; fewer options for monitoring compared to hospitalization; and problems regarding control of patient behavior. 4.) Participants’ preferences. All preferred CTH to hospitalization. 5.) Participants’ suggestions for improving CTH. These included the need not only to provide patients with better information, but also to improve the involvement of relatives during treatment.

Conclusion
The interviewees found that CTH might help to avoid hospitalization by providing stakeholders with more options for arranging effective care at home. Although this suggests that initial experiences of CTH under the new Dutch mental health law were positive, it is still uncertain whether CTH as currently implemented really differs from CCT.
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Authors: Hong Chien-Tai , Chen Jia-Hung , Hu Chaur-Jong 
Published: November 2024

AbstractNeurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are common complications of diabetes, arising from insulin resistance, inflammation, and other pathological processes in the central nervous system. The potential of numerous antidiabetic agents to modify neurodegenerative disease progression, both preclinically and clinically, has been assessed. These agents may provide additional therapeutic benefits beyond glycemic control. Introduced in the twenty-first century, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of antidiabetic drugs noted not only for their potent glucose-lowering effects but also for their cardiovascular and renal protective benefits. Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins. These agents also have substantial protective effects on cognitive and behavioral functions, such as motor function. However, clinical trials investigating GLP-1RAs in diseases such as AD, PD, mild cognitive impairment, psychiatric disorders, and diabetes have yielded mixed results for cognitive and motor function. This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD. This review also proposed new strategies for the design of future clinical trials on GLP-1 RAs for both AD and PD.