bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges achieving horizontal coherence across health and public security policies in formulating Uruguay’s cannabis regulation
Authors: Barry Rachel Ann 
Published: November 2024

Abstract
In 2013, Uruguay became the first country to regulate the legal production, distribution and sale of recreational cannabis. While key officials have framed Uruguay’s landmark legislation as part of the government’s strategy to regulate cannabis, tobacco and alcohol, there is limited empirical research exploring the political considerations that influenced its approach. Drawing on the concept of policy coherence—the process by which policymakers seek to minimize conflicts and maximize synergies across policy agendas—this study explores the extent to which Uruguay’s cannabis regulation was influenced by the promotion of policy coherence within health and across other policy spheres. Government documents, 43 semi-structured interviews and field observations were thematically analysed. The analysis shows that the pursuit of policy coherence across health issues was relatively limited, and where there is an element of regulatory coherence, there also appears to be minimal coordination. Efforts to promote substantive policy coherence were shaped by a desire to legitimate cannabis use without creating an upstream driver or structural force that would promote excessive consumption. The findings also reveal that the outcome of Uruguay’s cannabis regulation was more directly shaped by broader political considerations, including how to resolve tensions between public security and unhealthy commodity regulation goals. This study raises important questions around the extent to which Uruguay’s cannabis regulation was shaped by the explicit goal of policy coherence, suggesting rather that comparisons with tobacco and alcohol regulation were strategically used to justify the introduction of a legally regulated cannabis market.
The evolution of cyberconflict studies
Authors: Dunn Cavelty Myriam , Pulver Tobias , Smeets Max 
Published: November 2024

Abstract
In our increasingly digital world, cyberconflict poses a significant challenge to global security, prompting the emergence of an academic field dedicated to its study. Understanding the trajectory, evolution and dominant characteristics of cyberconflict studies is vital for scholars and policy-makers alike. By means of a thorough analysis of articles from the 125 top political science and International Relations journals, we illuminate the field's conceptual and methodological landscape. Our findings uncover a notable Europeanization of the field and a shift towards more rigorous methodologies, particularly experimental designs. While early research focused primarily on conceptual development and strategic topics, the contemporary field of studies exhibits a broader scope and greater diversity of scholarship. While the field has progressed beyond its nascent stages, it has yet to reach its full potential. We address several potential issues facing its growth and relevance. Firstly, there is a lack of global representation among researchers and in the incidents studied. Secondly, embracing interdisciplinary approaches is crucial for addressing newly emerging issues effectively. Thirdly, the diversification of research identities within the field of cyberconflict studies in the US and Europe must be bridged to foster collaboration and exchange of ideas. To overcome these challenges, adopting a pragmatic middle-ground approach is essential.
A feminist cybersecurity: addressing the crisis of cyber(in)security
Authors: Mhajne Anwar , Whetstone Crystal 
Published: November 2024

Abstract
This article draws on feminist security studies (FSS) to construct a more inclusive cybersecurity. We ask: What can a gendered lens do for cybersecurity? Methodologically, this exploratory piece brings FSS insights to bear on studies in cybersecurity (both traditional and critical) to better conceptualize the risks and benefits embedded in the cybersphere, as well as the role of gender in cyberspace. We propose incorporating a gendered lens (an intersectional approach) to shed light on violence and insecurity online. Without recognizing gendering in the cyber realm, including how gender intersects with other systems of oppression, cybersecurity scholars and policy-makers cannot fully understand what we term the crisis of cyber(in)security. Additionally, we challenge simplistic solutions that rely solely on human rights protections in cyberspace. Such approaches often reinforce existing gender and power hierarchies through protectionist discourse. Our FSS-based understanding of cybersecurity has important policy implications. It calls for increased access and diverse participation in cybersecurity policy-making and diplomacy, and promotes a more thoughtful approach to human rights protection to address a broader range of cyber-based insecurities and forms of violence.
Challenging the “norm”: a critical look at deaf-hearing comparison studies in research
Authors: Holcomb Leala , Hall Wyatte C , Gardiner-Walsh Stephanie J , Scott Jessica 
Published: November 2024

Abstract
This study critically examines the biases and methodological shortcomings in studies comparing deaf and hearing populations, demonstrating their implications for both the reliability and ethics of research in deaf education. Upon reviewing the 20 most-cited deaf-hearing comparison studies, we identified recurring fallacies such as the presumption of hearing ideological biases, the use of heterogeneously small samples, and the misinterpretation of critical variables. Our research reveals a propensity to biased conclusions based on the norms of white, hearing, monolingual English speakers. This dependence upholds eugenics ideas and scientific ableism, which reinforces current power dynamics that marginalize the epistemologies and lived experiences of deaf populations. Going forward, it will be imperative for deaf people to be included in meaningful roles in deaf-related research as active contributors who help define the whole research process. Without this shift, the research risks remaining detached from the very populations it seeks to understand.
Structural insights into human ELAC2 as a tRNA 3′ processing enzyme
Authors: Xue Chenyang , Tian Junshan , Chen Yanhong , Liu Zhongmin 
Published: November 2024

Abstract
Human elaC ribonuclease Z 2 (ELAC2) removes the 3′ trailer of precursor transfer ribonucleic acid (pre-tRNA). Mutations in ELAC2 are highly associated with the development of prostate cancer and hypertrophic cardiomyopathy. However, the catalytic mechanism of ELAC2 remains unclear. We determined the cryogenic electron microscopy structures of human ELAC2 in various states, including the apo, pre-tRNA–bound and tRNA-bound states, which enabled us to identify the structural basis for its binding to pre-tRNA and cleavage of the 3′ trailer. Notably, conformational rearrangement of the C-terminal helix was related to feeding of the 3′ trailer into the cleavage site, possibly explaining why its mutations are associated with disease. We further used biochemical assays to analyse the structural effects of disease-related mutations of human ELAC2. Collectively, our data provide a comprehensive structural basis for how ELAC2 recruits pre-tRNA via its flexible arm domain and guides the 3′ trailer of pre-tRNA into the active centre for cleavage by its C-terminal helix.
ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules
Authors: Mariani Davide , Setti Adriano , Castagnetti Francesco , Vitiello Erika , Stufera Mecarelli Lorenzo , Di Timoteo Gaia , Giuliani Andrea , D’Angelo Angelo , Santini Tiziana , Perego Eleonora , Zappone Sabrina , Liessi Nara , Armirotti Andrea , Vicidomini Giuseppe , Bozzoni Irene 
Published: November 2024

Abstract
Stress granules (SG) are part of a cellular protection mechanism where untranslated messenger RNAs and RNA-binding proteins are stored upon conditions of cellular stress. Compositional variations due to qualitative or quantitative protein changes can disrupt their functionality and alter their structure. This is the case of different forms of amyotrophic lateral sclerosis (ALS) where a causative link has been proposed between the cytoplasmic de-localization of mutant proteins, such as FUS (Fused in Sarcoma), and the formation of cytotoxic inclusions. Here, we describe the SG transcriptome in neuroblastoma cells and define several features for RNA recruitment in these condensates. We demonstrate that SG dynamics and RNA content are strongly modified by the incorporation of mutant FUS, switching to a more unstructured, AU-rich SG transcriptome. Moreover, we show that mutant FUS, together with its protein interactors and their target RNAs, are responsible for the reshaping of the mutant SG transcriptome with alterations that can be linked to neurodegeneration. Our data describe the molecular differences between physiological and pathological SG in ALS-FUS conditions, showing how FUS mutations impact the RNA and protein composition of these condensates.
Self-management interventions to patients with cirrhosis: A scoping review
Authors: Aden Samsam , Lauridsen Mette Munk , Grønkjær Lea Ladegaard 
Published: November 2024

Background:
Self-management in chronic diseases like cirrhosis involves patients providing the necessary knowledge, skills, and confidence to enhance self-efficacy. This scoping review aims to describe the literature on self-management interventions in patients with cirrhosis to create an overview and identify key concepts and gaps in the existing literature.

Methods:
Four databases (CINAHL, Embase, Medline, and Scopus) were searched from November 2022 to September 2024. The review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews. Studies published from 2000 onward, including patients with cirrhosis of different etiology and severity, focusing on self-management and/or self-efficacy, and performed in a health care setting, were considered.

Results:
The search produced 1012 articles, of which 16 were included in the review. These represented studies from 7 countries and a sample of 1.276 patients. The studies differed in study design, sample size, delivery format, self-management interventions designed by the authors, and evaluation. However, all studies described some form of improvement in patient-related and clinical outcomes after the intervention, mainly improved patient knowledge and quality of life.

Conclusions:
Self-management interventions for patients with cirrhosis improved patient-related outcomes. However, more comprehensive and standardized interventions tailored to patients’ needs are needed. These self-management interventions should focus on increasing confidence and self-efficacy and address the different skills required by patients to manage their disease.
An Online Training Program Was Effective on Improving Physical Performance and Body Composition in U20 Soccer Players During the COVID-19 Quarantine
Authors: Veeck Filipe , Grazioli Rafael , Oliveira Gabriel S. , Baroni Bruno M. , Cadore Eduardo Lusa , Pinto Ronei Silveira 
Published: November 2024

Abstract
It is recommended for athletes keep training to reduce the negative effects of detraining. This study aimed to verify the effects of a 15-week online training intervention during a pandemic quarantine in body composition and physical capacity of highly trained soccer players. Sixteen male under-20 soccer players were assessed after the first period of COVID-19 quarantine (March 2020 to September 2020; 170 days), and after the second period of COVID-19 quarantine (November 2020 to February 2021, 107 days). Body composition, vertical jump height, hamstring maximum strength and aerobic capacity were assessed. The online training program was performed during the second lockdown. In comparison with first pre assessments, results showed that fat mass (−0.95 ± 1.27), free fat mass (1.22 ± 1.19), squat jump height (5.36 ± 1.99) and counter movement jump (3.19 ± 3.77) were significantly improved (P < 0.05). However, there were no significant changes in total body mass, hamstring eccentric strength, and Yo-Yo IR1 after online training (P > 0.05). In summary, the findings of this study highlight the importance of carrying out a training program during a period of absence from traditional soccer training, in order to maintain the level of physical capacities of youth soccer players.
The Impact of Visual Distraction Interventions on Patients’ Pain and Anxiety During Colonoscopy
Authors: Saab Omar , Al-Obaidi Hasan , Merza Nooraldin , Bhagat Umesh , Al-Sagban Alhareth , Algodi Marwah , Abuelazm Mohamed , El-Serag Hashem 
Published: November 2024

Background and Objective:
Patients undergoing colonoscopy may experience psychological distress related to the procedure, which may deter adherence and acceptance of future colonoscopies. Visual/audiovisual distraction interventions to alleviate colonoscopy-related pain and anxiety have been developed. This study aims to investigate the impact of these interventions on colonoscopy-related outcomes.

Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) testing the efficacy of visual/audiovisual distraction. Eligible studies were systematically retrieved by searching PubMed, EMBASE, WOS, SCOPUS, and Cochrane through June 2024 and extracted by 2 investigators. Continuous and dichotomous outcome variables were pooled using Cohen’s d and risk ratio (RR) with confidence interval (CI) using Stata MP version 17. We assessed heterogeneity using the χ2 test and I
2 statistic (PROSPERO ID: CRD42024555902).

Results:
We included 13 RCTs with 1439 patients randomized to an active intervention (n=804) or usual care (n=635). Only 3 RCTs were endoscopists-blinded studies, whereas the rest were open-label. The interventions included playing nature scene videos, real-time videos of the colonoscopy, or movies preferred by the patients. The active intervention arm was associated with a significant reduction in the pain experienced during colonoscopy (Cohen’s d: −0.57, 95% CI [−0.79, −0.35], P<0.0001), reduced anxiety related to colonoscopy (Cohen’s d: −0.66, 95% CI [−1.15, −0.18], P=0.01), and increased patients’ satisfaction (Cohen’s d: 0.65, 95% CI [0.49, 0.80], P<0.0001) compared with patients who received the usual care during colonoscopy. There were no significant differences between both groups in the willingness to re-undergo the procedure (RR: 1.11, 95% CI [0.98, 1.25], P=0.09), analgesia use (Cohen’s d: −0.21, 95% CI [−0.42, 0.0], P=0.05), or total procedure duration (Cohen’s d: −0.12, 95% CI [−0.24, 0.0], P=0.06).

Conclusions:
Visual/audiovisual distraction interventions decrease colonoscopy-associated pain and anxiety and increase patients’ satisfaction. These are promising interventions to improve patient compliance and quality of care during colonoscopy.
Brain Fog in Gastrointestinal Disorders
Authors: El Halabi Maan , Arwani Remy , Rao Satish C. , Parkman Henry P. 
Published: November 2024

Introduction:
Brain fog (BF) is a term used to describe difficulties with concentration, memory, and overall mental clarity. Links of BF to chronic fatigue syndrome and COVID-19 have been described, as well as recently to small intestinal bacterial overgrowth (SIBO) and probiotics.

Aim:
To investigate the association between BF, SIBO, intestinal methanogen overgrowth (IMO), gastrointestinal (GI) medications, and specific GI disorders [irritable bowel syndrome (IBS) and gastroparesis] by utilizing a questionnaire to help diagnose BF.

Methods:
Patients undergoing lactulose breath testing (LBT) for clinical assessment of SIBO filled out a demographic questionnaire, including an inquiry about the presence of BF, a symptom questionnaire (PAGI-SYM), and a BF Questionnaire (BFQ; 20 BF symptoms rated never=0 to always=4, total score 0 to 80).

Results:
A total of 102 patients underwent LBT, with the most common indication being bloating (67%), of whom 55 (54%) reported BF. The BFQ score was significantly higher in patients reporting BF than those not [38.2±15.6 vs. 10.9±9.4 (SEM) (P=0.001)]. Patients with BF were more likely to be on probiotics and proton pump inhibitors compared with those without BF (P=0.04). There was no major difference in the use of narcotics, prokinetics, or prebiotics. Gastroparesis and IBS were more common in patients who reported BF (P=0.01 and 0.05, respectively), but not SIBO or IMO by breath testing.

Conclusions:
BF was observed in over one-half of patients with common GI disorders. The prevalence of BF was higher in patients on probiotics and those with gastroparesis and IBS. The BFQ may be useful to diagnose and quantify BF severity.
Exploring female fitness app users’ motivations and perceptions: A qualitative study
Authors: Lyu Le , Abidin Nor Eeza Zainal , Zulnaidi Hutkemri 
Published: November 2024

Background:
Women make up nearly 60% of fitness App users and play an important role in the operation and development of these Apps. Despite the widespread adoption of fitness Apps in recent years due to their many physical and mental benefits, the use of Apps tends to be short-term, and user engagement is relatively low. Little is known about the factors that motivate female users to consistently use fitness Apps. This study aimed to study attributes of fitness Apps that are most likely to influence female users during their use of Apps.

Methods:
The means-ends chain theory and the soft-laddering interview technique were used to analyze the attributes that influenced females’ perceptions of fitness apps, focusing on the features most likely to provide them with benefits and value.

Result:
The results of the study indicated that instructiveness, interaction, personalization, ease of use, and convenience were the most important attributes valued by female fitness App users; peer support, entertainment, and exercise adherence were the most important consequences; and health, self-fulfillment, enjoyment of life and sense of achievement were the most important values.

Conclusion:
The findings provide researchers and management of fitness Apps and women’s sports with valuable insights from the means-ends chain theory, as well as suggestions for applying App design and promotion.
Effect of theta burst stimulation on lower extremity motor function improvement and balance recovery in patients with stroke: A systematic review and meta-analysis of randomized controlled trials
Authors: Chen Kang , Sun Meixia , Zhuang He 
Published: November 2024

Background:
To investigate the therapeutic benefits of theta burst stimulation on lower-limb motor dysfunction and balance recovery in patients with stroke.

Methods:
A literature search was performed across CNKI, CBM, WanFang, VIP, PubMed, Embase, Cochrane Library, and Web of Science until November 2023. The Methodological quality of included studies was assessed by using the Cochrane risk-of-bias tool and the PEDro scale, and the meta-analysis was performed by using RevMan 5.3 software. Two independent researchers screened the literature and extracted basic information on participants, interventions, comparisons, outcomes, and studies.

Results:
Eight studies, including cTBS and iTBS, with 290 participants meeting the inclusion criteria for this systematic review, and 7 studies including only iTBS with 230 participants were included in this meta-analysis. The methodological quality of the studies included ranged from moderate to high. The results showed iTBS had significantly higher scores on the Berg Balance Scale (BBS) than the control group. (MD = 4.57, 95% CI: 1.76 to 7.38, Z = 3.19, P = .001). Subgroup analysis showed CRB-iTBS markedly improved BBS scores (MD = 4.52, 95% CI: 1.78 to 7.27, Z = 3.23, P = .001), whereas LE M1-iTBS did not exhibit a significant enhancement in BBS scores (MD = 6.10, 95% CI: −7.34 to 19.53, Z = 0.89, P = .37); iTBS showed no significant increase in lower-limb motor function (FMA-LE) (MD = 1.80, 95% CI: −1.10 to 4.69, Z = 1.22, P = .22). Subgroup analysis revealed both CRB-iTBS and LE M1-iTBS interventions were not effective in improving FMA-LE (MD = 3.15, 95% CI: −4.70 to 11.00, Z = .79, P = .43; MD = 1.05, 95% CI: −2.20 to 4.30, Z = .63, P = .53); iTBS significantly reduced the MEP latency (P = .004), but did not show a significant improvement in walking performance (10 MWT), mobility (TUG), or activities of daily living [M(BI)] (P > .05).

Conclusion:
Based the current study, iTBS can increase patients’ balance function. The CRB-iTBS protocol is more effective than the LE M1-iTBS protocol. Additionally, iTBS may be a promising therapy tending to enhance lower-limb motor function, walking performance, mobility, and activities of daily living.
Efficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole in the treatment of acute cerebral infarction: A systematic review and meta-analysis
Authors: Lyu Yangting , Xu Bin 
Published: November 2024

Background:
To evaluate the clinical efficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole (GLED) versus edaravone alone in the treatment of acute cerebral infarction (ACI) by the method of meta-analysis.

Methods:
PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WANFANG DATA, and Chinese Scientific Journal Database were searched to identify publications on edaravone combined with GLED for ACI from inception to June 20, 2024. Stata15.0 statistical software was applied for data analysis. The test group was treated with edaravone combined with GLED, while the control group received edaravone alone.

Results:
A total of 12 records were involved in this meta-analysis. The combined results exhibited that the effective rate of edaravone combined with GLED was significantly higher than that of edaravone in the treatment of ACI (relative risk = 1.21, 95% confidence interval [CI] = 1.15–1.27, P < .001). The National Institute of Health stroke scale scores of edaravone combined with GLED were significantly lower than those of edaravone alone in the treatment of ACI (standardized mean difference = −1.93, 95% CI = −3.36 to −0.50, P = .008). The incidence of adverse reactions in the edaravone combined with GLED group was significantly lower than that in the edaravone alone group (relative risk = 0.48, 95% CI = 0.33–0.70, P < .001) in the treatment of ACI.

Conclusion:
The combination of edaravone with GLED for treating ACI has better efficacy and higher safety than edaravone alone. Given the limited number of studies identified and possibility of publication bias, the above findings should be verified by more high-quality trials in the future.