bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey on Medical Image Analysis in Capsule Endoscopy
Authors: Jani Kuntesh Ketan , Srivastava Rajeev 
Published: November 2018

Background and Objective:
Capsule Endoscopy (CE) is a non-invasive, patient-friendly
alternative to conventional endoscopy procedure. However, CE produces 6 to 8 hrs long video posing a tedious challenge to a gastroenterologist for abnormality detection. Major challenges to an
expert are lengthy videos, need of constant concentration and subjectivity of the abnormality. To
address these challenges along with high diagnostic accuracy, design and development of automated
abnormality detection system is a must. Machine learning and computer vision techniques are devised to develop such automated systems.

Methods:
Study presents a review of quality research papers published in IEEE, Scopus, and Science
Direct database with search criteria as capsule endoscopy, engineering, and journal papers. The initial search retrieved 144 publications. After evaluating all articles, 62 publications pertaining to image analysis are selected.

Results:
This paper presents a rigorous review comprising all the aspects of medical image analysis
concerning capsule endoscopy namely video summarization and redundant image elimination, Image
enhancement and interpretation, segmentation and region identification, Computer-aided abnormality detection in capsule endoscopy, Image and video compression. The study provides a comparative
analysis of various approaches, experimental setup, performance, strengths, and limitations of the
aspects stated above.

Conclusion:
The analyzed image analysis techniques for capsule endoscopy have not yet overcome
all current challenges mainly due to lack of dataset and complex nature of the gastrointestinal tract.
Exploring the Role of Water Molecules in the Ligand Binding Domain of PDE4B and PDE4D: Virtual Screening Based Molecular Docking of Some Active Scaffolds
Authors: Singh Priya , Mishra Mitali , Agarwal Shivangi , Sau Samaresh , Iyer Arun K. , Kashaw Sushil K. 
Published: November 2018

Background:
The phosphodiesterase (PDE) is a superfamily represented by four genes: PDE4A,
B,C, and D which cause the hydrolysis of phosphodiester bond of cAMP to yield inactive AMP. c-AMP
catalyzing enzyme is predominant in inflammatory and immunomodulatory cells. Therapy to treat Chronic
Obstructive Pulmonary Disease (COPD) with the use of PDE4 inhibitors is highly envisaged.

Objective:
A molecular docking experiment with large dataset of diverse scaffolds has been performed on
PDE4 inhibitors to analyze the role of amino acid responsible for binding and activation of the secondary
transmitters. Apart from the general docking experiment, the main focus was to discover the role of water
molecules present in the ligand-binding domain.

Methods:
All the compounds were docked in the PDE4B and PDE4D active cavity to produce the free
binding energy scores and spatial disposition/orientation of chemical groups of inhibitors around the cavity.
Under uniform condition, the experiments were carried out with and without water molecules in the LBD.
The exhaustive study was carried out on the Autodock 4.2 software and explored the role of water molecules
present in the binding domain.

Results:
In presence of water molecule, Roflumilast has more binding affinity (-8.48 Kcal/mol with
PDE4B enzyme and -8.91 Kcal/mol with PDE4D enzyme) and forms two hydrogen bonds with Gln443 and
Glu369 and amino acid with PDE4B and PDE4D enzymes respectively. While in absence of water molecule
its binding affinity has decreased (-7.3 Kcal/mol with PDE4B enzyme and -5.17 Kcal/mol with
PDE4D enzyme) as well as no H-bond interactions were observed. Similar observation was made with clinically
tested molecules.

Conclusion:
In protein-ligand binding interactions, appropriate selection of water molecules facilitated the
ligand binding, which eventually enhances the efficiency as well as the efficacy of ligand binding.
Effects of Temperature and Alloy Composition on Nanomechanical Properties of ZrCu Metallic Glass under Tension
Authors: Wu Cheng-Da , Fang Te-Hua , Chao Kuan-Chi 
Published: November 2018

Background:
The nanomechanical properties of Zr50Cu50 metallic glass under tension are
studied. The effects of temperature and alloy composition are investigated in terms of atomic trajectories,
slip vectors, stress-strain curve, and radial distribution function.

Methods:
The molecular dynamics simulations based on the many-body tight-binding potential are
applied to analyze the nanomechanical properties of metallic glass under tension.

Results:
The mechanical properties of the metallic glass are sensitive to temperature and alloy composition.
Under tensile deformation, the stress increases with increasing temperature and Zr content in
the alloys. At higher temperatures, the alloy atoms have high slip vectors, and plasticity becomes
more homogeneous due to a better flow ability of atoms.

Conclusion:
The alloys with higher Zr content have larger mechanical strengths. The alloys with
higher Cu content have more stable structures.
Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy
Authors: Ibarra Antonio , Mendieta-Arbesú Erika , Suarez-Meade Paola , García-Vences Elisa , Martiñón Susana , Rodriguez-Barrera Roxana , Lomelí Joel , Flores-Romero Adrian , Silva-García Raúl , Buzoianu-Anguiano Vinnitsa , Borlongan Cesar V. , Frydman Tamara D. 
Published: November 2018

Background:
The chronic phase of Spinal Cord (SC) injury is characterized by the presence
of a hostile microenvironment that causes low activity and a progressive decline in neurological function;
this phase is non-compatible with regeneration. Several treatment strategies have been investigated
in chronic SC injury with no satisfactory results. OBJECTIVE- In this proof-of-concept study,
we designed a combination therapy (Comb Tx) consisting of surgical glial scar removal plus scar inhibition,
accompanied with implantation of mesenchymal stem cells (MSC), and immunization with
neural-derived peptides (INDP).

Methods:
This study was divided into three subsets, all in which Sprague Dawley rats were subjected
to a complete SC transection. Sixty days after injury, animals were randomly allocated into two groups
for therapeutic intervention: control group and animals receiving the Comb-Tx. Sixty-three days after
treatment we carried out experiments analyzing motor recovery, presence of somatosensory evoked
potentials, neural regeneration-related genes, and histological evaluation of serotoninergic fibers.

Results:
Comb-Tx induced a significant locomotor and electrophysiological recovery. An increase in the
expression of regeneration-associated genes and the percentage of 5-HT+ fibers was noted at the caudal
stump of the SC of animals receiving the Comb-Tx. There was a significant correlation of locomotor recovery
with positive electrophysiological activity, expression of GAP43, and percentage of 5-HT+ fibers.

Conclusion:
Comb-Tx promotes motor and electrophysiological recovery in the chronic phase of SC
injury subsequent to a complete transection. Likewise, it is capable of inducing the permissive microenvironment
to promote axonal regeneration.
CMOS Active Inductor/Resonator Based Voltage Controlled Oscillator
Authors: Patel Dhara P. , Oza-Rahurkar Shruti 
Published: November 2018

Background:
A tunable CMOS active inductor/resonator based Voltage Controlled
Oscillator (VCO) has been presented. In the design of LC-VCO, LC resonator (tank) circuit has been
substituted with gyrator based CMOS active inductor/resonator. The purity of VCO output signal is
defined by the phase noise parameter.

Methods:
For good spectral purity of VCO output signal, the phase noise should be minimum.
Moreover, the quality factor of LC resonator is inversely proportional to the phase noise of VCO
output signal. In the presented work, a high-quality active inductor/resonator circuit has been used to
design VCO which minimizes the phase noise and chip area as well. Further, other VCO
characterization factors are measured.

Results:
The designed circuit has been implemented in 0.18µm CMOS technology.

Conclusion:
The design of the proposed AI based voltage controlled oscillator shows better phase
noise, less chip area and high output power. The high output power is achieved at the cost of limited
tuning range of 1.14 GHz ~ 2.1 GHz. The presented active inductor based voltage controlled oscillator
can be used for RF applications from 1.14GHz ~ 2.1GHz.
Eksplorasi Pengetahuan Obat Tradisional dalam Prespektif Hukum Kekayaan Intelektual di Bengkulu
Authors: Fitri Rahma , Oktiarni Dwi , Arso Dimas Dwi 
Published: November 2018

AbstractInventory of traditional medicine as a form to protect intellectual property of Bengkulu Province, to know the obstacle factor in exploring the knowledge of traditional medicine and to know the role of government in protecting knowledge of traditional medicine in Bengkulu. Research uses empirical research. The results show there is some traditional drug knowledge that can be explored by traditional drug makers. Traditional medicine has existed since hereditary and provide efficacy to the consumer. The exploration of this knowledge of the intellectual property element, some of the problems the makers do not know that the intellectual property can protect the existing culture. The role of government is needed to protect thenational culture, especially regional culture as an asset of the Indonesian nation.IntisariMenginventarisasi obat tradisional sebagai wujud untuk melindungi kekayaan intelektual Provinsi Bengkulu, untuk mengetahui faktor penghambat dalam eksplorasi pengetahuan obat tradisional serta untuk mengetahui peran pemerintah dalam melindungi pengetahuan obat tradisional di Bengkulu. Penelitian menggunakan penelitian empiris. Hasil penelitian menunjukkan terdapat beberapa pengetahuan obat tradisional yang dapat dieksplorasi oleh pembuat obat tradisional. Obat tradisional telah ada sejak turun temurun dan memberikan khasiat kepada konsumen. Eksplorasi pengetahuan ini unsur kekayaan intelektual, beberapa permasalahan pembuat tidak mengetahui bahwa kekayaan intelektual itu dapat melindungi kebudayaan yang telah ada. Peran pemerintah sangat diperlukan ntuk melindungi kebudayaan nasional terutama kebudayaan daerah sebagai asset bangsa Indonesia.
International Law Analysis of The Restrictions Imposed on Remote Sensing Satellite Through Shutter Control
Authors: Sitanggang Dyan Franciska Dumaris 
Published: November 2018

AbstractThis paper addresses the issue concerning state’s control over the activities of remote sensing (RS) satellites that can surveil its territory, as well as other states territories, and also able to disseminate confidential information, which could jeopardize the state’s national security and foreign policy. The author proposes that Indonesia should assert its right to control the activities of RS satellites as other countries do through ‘shutter control’ regulations. The author also examines several approaches that could be used to determine the allowed RS satellite activities, as well as other countries practices that might help to formulate new norms concerning space-based activities.IntisariTulisan ini membahas isu kendali negara atas aktivitas satelit penginderaan jarak jauh, berdasarkan masalah kemampuan satelit penginderaan jarak jauh untuk pengamatan atas wilayah nasional negara asalnya juga negara-negara lain, menyebarkan informasi yang bersifat rahasia yang berbahaya bagi keamanan nasional dan kebijakan internasional negara tersebut. Penulis menyarankan agar Indonesia menyuarakan hak mengendalikan aktivitas satelit penginderaan jarak jauh sebagaimana dilakukan negara-negara melalui regulasi ‘kendali bidik’. Tulisan ini pun menganalisa pendekatan yang bisa digunakan untuk menentukan aktivitas satelit penginderaan jarak jauh yang diperbolehkan dan praktek negara-negara dapat membantu pembentukan norma baru dalam aktivitas luar angkasa.
Pemanfaatan Limbah Udang Terfermantasi Sebagai Pakan Ternak Sapi
Authors: Filawati Filawati , Mairizal Mairizal , Suparjo Suparjo 
Published: November 2018

Penelitian ini bertujuan untuk mengetahui level limbah udang terfermentasi dengan Probio – FM dalam ransum ternak sapi. Limbah udang terfermentasi dipergunakan sebagai pengganti konsentrat dengan level 0; 10; 20 and 30 % dari total konsentrat yang digunakan. Perbandingan hijauan dan konsentrat dalam ransum adalah 60:40. Rancangan yang digunakan dalam penelitian adalah Rancangan Acak Kelompok dengan 4 perlakuan dan 3 ulangan. Peubah yang diamati terdiri dari ransum masuk (nutrient feed intake) dan pertambahan bobot badan. Hasil dari penelitian menunjukkan bahwa perlakuan berpengaruh nyata (P<0.05) terhadap nutrient feed intake dan pertambahan bobot badan). Pemasukan tertinggi adalah 3.765 kg ekor-1 hari-1) dan pertambahan bobot badan (829.4 g ekor-1 hari-1) dapat dicapai dengan pemberian 10 % fermentasi limbah udang. Kesimpulan dalam penelitian ini adalah bahwa penggantian 10% konsentrat dengan limbah udang terfermentasi memberikan produksi tertinggi terhadap zat makanan masuk dan pertambahan bobot badan ternak sapi Kata Kunci : limbah udang terfermentasi, sapi, masukan makanan feed intake), pertambahan bobot badan
Nouvelles données sur la flore endémique du sous-secteur de l’Atlas tellien Oranais “O3” (Algérie occidentale)
Authors: Miara Mohamed Djamel , Ait Hammou Mohammed , Dahmani Walid , Negadi Moahmed , Djellaoui Abdelmadjid 
Published: November 2018

RésuméNouvelles données sur la flore endémique du sous-secteur de l’Atlas tellien Oranais «O3» (Algérie occidentale). Cette étude est une première synthèse régionale visant à proposer une nouvelle liste de la flore endémique du sous- secteur de l›Atlas tellien oranais (O3) en analysant les principaux changements taxonomiques et chorologique. Les données de littérature disponibles ont été exploitées notamment (Quezel & Santa, 1962-63; Vela & Benhouhou, 2007) et analysés en utilisant l’index de la base de données de l’Afrique du Nord (Dobignard & Chatelain, 2010-13). Cela a conduits à la suppression de 22 taxons de la liste de base comportant 94 taxons. Nous avons ensuite rajouté 15 nouveaux taxons signalés récemment dans la bibliographie au niveau de cette région ainsi que 3 taxons oubliés dans la première liste. La nouvelle liste de la flore endémique du O3 contenant 89 taxons a subi des changements considérables au niveau de sa composition floristique. Cette liste n’étant pas exhaustive devrait être enrichie par des nouveaux résultats au niveau des zones pas encore bien explorées sur le plan floristique notamment Mascara, Saida et Sidi Belabess. Mots clés: Algérie, chorologie, endémique,liste, taxonomie. AbstractNew data on endemic flora of the sub-sector of Oran Tell Atlas “O3” (Western Algeria). This study is a first regional synthesis aiming at proposing a new list of the endemic flora of the sub-sector of Oran Tell Atlas (O3), by analyzing the main taxonomic and chorological changes. The literature data available have been exploited in particular (Quézel & Santa, 1962-63, VÉla & Benhouhou, 2007) and analyzed using the index of the database of North Africa (Dobignard & Chatelain, 2010-13). This led to the deletion of 22 taxa from the basic list of 94 taxa. We then added 15 new taxa reported recently in the bibliography at this region as well as 3 taxa forgotten in the first list. The new list of endemic flora of O3 containing 89 taxa has undergone considerable changes in its floristic composition. This list which is not exhaustive should be enriched by new results at the level of areas not yet well explored on the floristic plan including Mascara, Saida and Sidi Belabess. Key words: Algeria, chorology, endemic, list, taxonomy.
Effects of the use of silver-coated urinary catheters on the incidence of catheter-associated bacteriuria and urinary tract infection in dogs
Authors: Ogilvie Adam T. , Brisson Brigitte A. , Gow William R. , Wainberg Shannon , Singh Ameet , Weese J. Scott 
Published: November 2018

Abstract
OBJECTIVE To determine the effects of silver-coated versus standard silicone urinary catheters on the incidence of catheter-associated bacteriuria (CAB) and catheter-associated urinary tract infection (CAUTI) in dogs.
DESIGN Randomized controlled clinical trial.
ANIMALS 36 dogs requiring urinary bladder catheterization for ≥ 24 hours.
PROCEDURES Dogs were randomly assigned to receive a silver-coated or non–silver-coated (control) silicone Foley catheter. Urine samples for cytologic examination and bacterial culture were collected at the time of catheter insertion and daily until catheters were removed (≥ 24 hours to 7 days later). Results were compared between groups.
RESULTS No significant differences were identified between catheter groups in the incidence of CAB or CAUTI. Although the median time to development of cytologically detected bacteriuria, culture-detected bacteriuria, and CAUTI did not differ significantly between groups, median time to CAB development (either method) was significantly longer for dogs that received a control catheter rather than a silver-coated catheter. For both types of catheters combined, older age was a significant predictor of culture-detected bacteriuria, and longer duration of catheterization was a significant predictor of culture-detected bacteriuria and overall CAB.
CONCLUSIONS AND CLINICAL RELEVANCE Silver-coated urinary catheters provided no clinical benefit over standard urinary catheters for the dogs of this study and were associated with earlier development of CAB but not CAUTI. A larger prospective study is required to definitively determine whether the use of silver-coated urinary catheters should or should not be considered to reduce the risk of CAB or CAUTI in dogs.
Exploration of veterinary shortages in the wake of the Veterinary Feed Directive
Authors: Tack Danielle M. , McCool-Eye Mary Jane , Kizer Christopher R. , Dargatz David A. , Turzillo Adele M. 
Published: November 2018

Abstract
OBJECTIVE To identify geographic areas in the United States where food animal veterinary services may be insufficient to meet increased needs associated with the US FDA's Veterinary Feed Directive.
DESIGN Cross-sectional study.
SAMPLE Data collected between 2010 and 2016 from the US Veterinary Medicine Loan Repayment Program, the National Animal Health Monitoring System Small-Scale US Livestock Operations Study, and the USDA's National Veterinary Accreditation Program.
PROCEDURES Each dataset was analyzed separately to identify geographic areas with greatest potential for veterinary shortages. Geographic information systems methods were used to identify co-occurrence among the datasets of counties with veterinary shortages.
RESULTS Analysis of the loan repayment program, Small-Scale Livestock Operations Study, and veterinary accreditation datasets revealed veterinary shortages in 314, 346, and 117 counties, respectively. Of the 3,140 counties in the United States during the study period, 728 (23.2%) counties were identified as veterinary shortage areas in at least 1 dataset. Specifically, 680 counties were identified as shortage areas in 1 dataset, 47 as shortage areas in 2 datasets, and 1 Arizona county as a shortage area in all 3 datasets. Arizona, Kentucky, Missouri, South Dakota, and Virginia had ≥ 3 counties identified as shortage areas in ≥ 2 datasets.
CONCLUSIONS AND CLINICAL RELEVANCE Many geographic areas were identified across the United States where food animal veterinary services may be inadequate to implement the Veterinary Feed Directive and meet other producer needs. This information can be used to assess the impact of federal regulations and programs and help understand the factors that influence access to food animal veterinary services in specific geographic areas.
АНАЛИЗ И ОЦЕНКА ПРОЦЕССА РАЗРАБОТКИ управленческого решения
Authors: Безматерных Алина Олеговна , Файзрахманова Екатерина Владимировн 
Published: November 2018

Аннотация. Предмет. К приоритетным проблемам на сегодняшний день можно отнести вопросы теории, методологии и практики управленческих решений. Рыночная ориентация требует от хозяйственных субъектов умения видеть перспективы, принимать эффективные стратегические управленческие решения в сложившихся условиях хозяйствования. Рост нестабильности условий деятельности предприятий, специфические особенности требуют учета множества факторов, в т. ч. и фактора неопределенности. Цель работы. В целях обеспечения устойчивого функционирования предприятия в изменяющихся, неопределенных условиях хозяйствования необходимо соблюдение и использование основных принципов стратегического менеджмента, реализация которых должна осуществляться, прежде всего, через принятие эффективных управленческих решений, основанных на системном подходе, анализе внешних и внутренних факторов, прямо или косвенно влияющих на деятельность предприятия. Методология. Принятие управленческих решений является одним из приоритетных элементов управленческого процесса на предприятии. С каждым днем возрастает потребность в обеспечении достаточно грамотного и качественного управления процессами, протекающими на предприятии. По мере усложнения хозяйственных ситуаций и управленческих задач возрастает проблема современного менеджмента. Результаты. Управленческие решения представляют собой основной инструмент управляющего воздействия. Возрастающие масштабы потерь, даже незначительных, которые руководители смогли допустить в решении, дают возможность говорить о значимости правильного и своевременного принятия управленческого решения. Выводы. Для верного управленческого решения необходимо воспользоваться правильным методом для решения конкретной проблемы, имеющей различную степень сложности и масштабности последствия. Но также не нужно упускать из внимания тот факт, что любой метод эффективен только в рамках той аксиоматики, для которой он разрабатывается.
РОЛЬ ТРАНСПОРТА В РАЗВИТИИ РЕГИОНАЛЬНЫХ ИНТЕГРАЦИОННЫХ ПРОЦЕССОВ В МИРОВОЙ ЭКОНОМИКЕ
Authors: Комов Михаил Сергеевич 
Published: November 2018

Целью работы является обоснование и оценка роли транспорта в развитии региональных интеграционных процессов, происходящих в современной мировой экономике.
Методология работы основывается на общенаучных методах анализа научной литературы, системных и логических методах, моделирования. Основой данной работы также являются фундаментальные труды отечественных и зарубежных ученых по проблемам влияния транспортного фактора на региональную экономическую интеграцию. Результаты работы. Проведен анализ теоретических подходов различных исследователей, рассматривающих транспортный комплекс как ключевой фактор формирования региональной экономической интеграции, рассмотрена авторская позиция по этому вопросу. Выявлены эффекты модернизации транспортной инфраструктуры. Доказана роль транспорта в стимулировании экономического роста и развития регионов в мировой экономике. Область применения результатов. Результаты проведенного исследования могут быть использованы правительственными органами интегрирующихся стран при формирования единого транспортного пространства в регионе. Выводы. Установлены группы отраслей, зависимые от влияния транспортной инфраструктуры. Выявлены основные методы оценки транспортных затрат. В результате исследования автором статьи обоснована и доказана роль транспорта как ключевого фактора региональной экономической интеграции в мировой экономике.