bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les avatars de la Chute dans trois romans de Loys Masson (1915-1969)
Authors: Zatorska Izabella 
Published: August 2019

L’article entreprend l’examen du traitement littéraire de la matière biblique dans trois romans de Loys Masson, écrivain mauricien ayant passé les deux tiers de sa vie en France : Les Tortues (1956), Le Notaire des noirs (1961), Les Noces de la vanille (1962). Une définition du mythe littéraire, distingué du mythe biblique, est d’abord établie, puis appliquée aux narrations symboliques de ce poète et romancier communiste (de 1942 à 1948) et catholique, que son ami Claude Roy présentait comme un « Adam cherchant à rejeter sur Dieu la responsabilité de sa faute ».
Impaired vascular reactivity in sepsis – a systematic review with meta-analysis
Authors: Kazune Sigita , Piebalga Anda , Strike Eva , Vanags Indulis 
Published: August 2019

IntroductionVascular dysfunction due to reduced nitric oxide bioavailability plays an important role in the pathogenesis of sepsis. This meta-analysis examines evidence from published literature to evaluate whether in the adult population the presence/severity of sepsis is associated with impaired vasoreactivity.Material and methodsWe performed a search of the Medline, Scopus, and EMBASE databases to identify observational studies using measurement of reactive hyperaemia in adult patients with sepsis. After data extraction using predefined protocol, qualitative synthesis of findings was performed regarding consistency of findings between methods, evidence of association between vascular reactivity and severity of sepsis, multiple organ failure, and death. A meta-analyses of standardised mean differences in vasoreactivity between groups was performed, in which data were available for relevant outcomes.ResultsEighteen studies using four methods to measure vascular reactivity from a total of 466 were included in the analysis. The pooled standardised mean difference estimate showed that septic patients had less reactive hyperaemia than controls (–2.59, 95% CI: –3.46 to –1.72; p < 0.00001), and peak hyperaemic blood flow was lower in patients with sepsis than in the control group (SMD = –1.42, 95% CI: –2.14 to –0.70; p = 0.0001). The combined SMD between non survivors and survivors was –0.36 (95% CI: –0.67 to –0.06; p = 0.02) for reactive hyperaemia and –0.70 (95% CI: –1.13 to –0.27; p = 0.001) for peak hyperaemic blood flow.ConclusionsSeptic patients have attenuated vascular reactivity when compared to healthy volunteers. There are insufficient data indicating that these changes can identify patients at risk of worsening organ failure or death.
Antithrombotic/antiplatelet therapy and colonoscopy results in patients over 50 with iron-deficiency anemia
Authors: Olmez Tolga , Bozkurt Hilmi , Gulmez Selcuk , Aray Emre , Sert Zeliha Ozlem , Kaplan Esin , Bulut Can Ibrahim , Karakose Erdal , Polat Erdal , Duman Mustafa 
Published: August 2019

IntroductionThis study aims to evaluate the results of asymptomatic patients who have been using anticoagulant-antiaggregant (AC-AA) agents and have had colonoscopy screening due to iron-deficiency anemia (IDA).Material and methodsThe data of 347 asymptomatic patients over the age of 50, who have received colonoscopy due to IDA, were reviewed retrospectively. The effects of sex and AC-AA administration on positive colonoscopy results, preneoplastic lesions and malignancy were investigated.ResultsOf 347 patients over 50 with IDA, 204 were female (58.8%). The mean age was 63.4 ±8.4. Positive colonoscopy results were observed more commonly in 69 male patients compared to 67 female patients (p = 0.004). Similarly, positive colonoscopy results were found to be more frequent among patients using AC-AA (p = 0.019). While premalignant lesions were more frequently diagnosed in male patients (23% to 10.2%), the results were also statistically significant (p = 0.002). Anticoagulant administration did not contribute to the increase in preneoplastic lesion rates (15.57% to 15.55%). Malignant pathology, which was seen in 8 male patients, was more common among male patients yet it was not statistically significant (p = 0.081). However, compared to 3 patients who did not use AC-AA, malignant pathology was seen more frequently in 9 patients who were on AC-AA and the figure was statistically significant (p = 0.009).ConclusionsThe AC-AA administration in asymptomatic patients over 50 with IDA who have had colonoscopy screening increases the rate of colorectal malignancy diagnosis, while it leads to no change in the rate of preneoplastic lesion detection. Nevertheless, male sex is a factor that increases the possibility of preneoplastic lesion detection.
Assessment of doctors’ knowledge, attitude and practice for hepatitis C virus infection control guidelines in Egypt
Authors: El-Sayed Hesham , Mehanna Sohair , Maraghy Nermine El , Younes Soha , Hassan Adel , Sheded Mahmoud , Khedr Zeinab 
Published: August 2019

IntroductionHepatitis C virus is a blood-borne infection and one of the major global problems. In Egypt, the prevalence is reported to be the highest. Infection through unsafe medical procedures is considered now the primary cause of infection. The study aims to assess the knowledge, attitude and practice of doctors regarding infection control guidelines in Ismailia governorate.Material and methodsA cross sectional study was conducted on a sample of physicians (355) in Ismailia governorate using a questionnaire to collect data on their knowledge and attitude concerning the control measures related to their years of experiences.ResultsMost of the physicians (89.6%) regardless of their years of experience have had contact with blood products. Those who had a history of needle stick injury accounted for 56.3%, with a statistically significant difference as to the highest number being middle career physicians. Concerning knowledge about infection control policies in their hospitals, it was relatively low among all groups.ConclusionsDespite all efforts exerted by the infection control professionals, infections still remain a major unpleasant side effect of health care, often causing harm to patients.. Although Egypt has made great progress in implementing the infection control procedures and policies, there is still a huge problem as the practices of physicians do not really reflect their knowledge and they still do not follow the infection control policies. Education, monitoring, improved availability of resources and disciplinary measures are necessary to improve infection control in health facilities that should be applied to all physicians.
Atrial fibrillation influences automatic oscillometric ankle-brachial index measurement
Authors: Dąbrowski Michał , Lewandowski Jacek , Szmigielski Cezary , Siński Maciej 
Published: August 2019

IntroductionRepeated measurements of ankle-brachial index (ABI) using Doppler method were shown to be accurate during atrial fibrillation. Oscillometric devices are effective in ABI measurement, but their accuracy during atrial fibrillation is unknown. The purpose of the study was to investigate whether atrial fibrillation influences ABI obtained with the automatic oscillometric method.Material and methodsNinety-nine patients with atrial fibrillation (mean age: 66.6 +(SD = 11) years, M/F  63/36) who underwent electrical cardioversion were investigated (198 lower extremities). The ABI measurements using oscillometric and Doppler methods were performed on both lower extremities before and after procedure.ResultsThe ABI measured using the oscillometric method on both lower limbs did not change after cardioversion (1.21 (IQR: 1.13-1.27) vs. 1.22 (IQR: 1.14-1.26), p = 0.664, respectively). The ABI measured before and after cardioversion using Doppler and oscillometric methods showed a significant difference (1.14 (IQR: 1.07-1.22) vs. 1.21 (IQR 1.13-1.27), p < 0.001 and 1.18 (IQR: 1.09-1.13) vs. 1.22 (IQR: 1.14-1.26), p < 0.001 respectively). Both methods showed a weak correlation before (r = 0.35, p < 0.001) and no correlation after cardioversion (r = 0.12, p = 0.07). The Bland-Altman plot showed poor agreement between measurements performed with the Doppler and oscillometric methods in sinus rhythm and during atrial fibrillation.ConclusionsThe automated oscillometric method of ABI measurements should not replace the reference Doppler method in patients with atrial fibrillation. More research related to the oscillometric measurements is needed in subjects with peripheral artery disease and atrial fibrillation.
Cerebrovascular accidents differ between patients with atrial flutter and patients with atrial fibrillation
Authors: Staszewski Jacek , Bilbin-Bukowska Anna , Szypowski Wojciech , Mejer-Zahorowski Marcin , Stępień Adam 
Published: August 2019

IntroductionFew studies have explored the potential impact of atrial flutter (AFl) on ischaemic stroke (IS) outcome. The aim of the present study was to compare the clinical course of IS in patients with AFl and patients with atrial fibrillation (AF).Material and methodsA retrospective analysis of patients consecutively admitted to a tertiary care centre between 2013 and 2015 due to IS or transient ischaem-ic attack with permanent AFl or permanent or persistent AF was performed.ResultsThe study groups consisted of 528 patients, including 490 (92.8%) patients with AF and 38 (7.2%) patients with AFl. The mean age and prestroke CHA2DS2-VASc scores were similar between the patients with AFl and those with AF. Most IS cases in the AF group were clas-sified as cardioembolic strokes (74.9% vs. 39.5% in AFl, p < 0.01), and lacunar strokes were the most common in the AFl group (47.4% vs. 14.3% in AF, p < 0.01). The multivariable analysis revealed that the presence of AF (OR = 8.6, 95% CI: 1.2–57, p = 0.02), lacunar stroke (OR = 0.1, 95% CI: 0.03–0.31, p < 0.001), baseline Rankin scale score (OR = 16.6, 95% CI: 9.8–28), lack of prestroke therapeutic anticoagulation (OR = 6.1, 95% CI: 1.1–33), diabetes (OR = 2.9, 95% CI: 1.3–6.5, p < 0.01), chronic heart failure (OR = 14.2, 95% CI: 5.8–34, p < 0.001), and current smoking (OR = 0.92, 95% CI: 0.39–0.99, p < 0.01) were significantly associated with the stroke outcome.ConclusionsDisabling or fatal IS was observed less often in patients with AFl than in patients with AF. This finding can possibly be explained by the more frequent occurrence of lacunar strokes in the AFl group compared with that in the AF group.
Factors affecting body awareness in older adults with chronic musculoskeletal pain
Authors: Baskan Emre , Yagci Nesrin , Cavlak Ugur 
Published: August 2019

IntroductionChronic musculoskeletal pain (CMP) and cognitive impairment (CI) may reduce body awareness in older adults. The first aim of this study was to determine the impact of CMP and CI on body awareness in older adults. The second was to search for the factors most affecting body awareness using logistic regression analysis.Material and methodsTwo hundred and 65 older adults (males: 138 and females: 127) aged 65 and over (mean age; 72.27 ±6.42 years) living in their own homes were included. We used the following evaluation methods: CMP intensity (Visual Analog Scale – VAS), cognitive status (Hodkinson’s Abbreviated Mental Test – HAMT), and body awareness (Body Awareness Questionnaire – BAQ). Logistic regression analysis was used to determine the factor most affecting the BAQ score.ResultsEighty-five point two percent of participants (n = 265) reported CMP (lower extremity pain: 74.6%; spinal pain: 66.6%; upper extremities pain: 44.4%). CMP intensity was higher in lower extremities (mean VAS: 5.73 ±1.86 cm). Gender differences in terms of CMP were found in favor of males (p = 0.0001). Mean HAMT score was 8.16±1.65. Gender difference in favor of males was significant (p = 0.0001). Mean BAQ score was 77.61±20.90; there was no significant difference between the gender (p = 0.142). There was a significant moderate positive correlation between body awareness and cognitive status (r = 0.382, p = 0.0001). However, a weak negative correlation was found between body awareness and pain intensity (r = –0.234, p = 0.0001). Regression analysis showed that living environment (rural area), low education level, low cognition level and increased CMP intensity significantly predicted body awareness.ConclusionsThe results obtained from this study indicate that cognitive impairment and pain should be reduced by improving body awareness among older adults. That is why health professionals should evaluate all related factors affecting body awareness before planning the most suitable rehabilitation program.
Medullary breast cancer is a predominantly triple-negative breast cancer – histopathological analysis and comparison with invasive ductal breast cancer
Authors: Budzik Michał , Sobieraj Maciej , Sobol Maria , Patera Janusz , Czerw Aleksandra , Deptała Andrzej , Badowska-Kozakiewicz Anna 
Published: August 2019

IntroductionMedullary breast cancer (MdBC) is an uncommon type of breast cancer representing 1–7% of all cases. It is characterized by the occurrence of many histopathological features associated with a high grade of malignancy.Material and methodsTwelve MdBCs chosen from a group of 1,122 women suffering from invasive breast cancer were analyzed. Histopathological examination and analysis of a basic molecular profile, i.e. estrogen (ER), progesterone (PR) and HER2 receptor expression, and their comparison with invasive ductal breast cancer (IDC), were performed.ResultsMdBC accounted for 1.07% of all analyzed invasive breast cancer patients. All patients were female, with an average age of 58.54 years. The MdBC group exhibited a larger median tumor diameter (2.05 vs. 1.89 cm), although ≥ T2 tumors comprised 42% vs. 51% for IDCs. Women without regional lymph node involvement (pN0) (83%) formed the largest group. There was a statistically significant difference in the presence of nodal involvement between the studied groups (p < 0.001). Based on the histological grade of malignancy, the majority of MdBC comprised grade II tumors (G2) (93%). In general, MdBC showed statistically higher histologic grade (G1-G3) than IDC (p = 0.003). The 5-year overall survival rate of MdBC patients was 91%. Most MdBCs (92%) were triple-negative, whereas the remaining 8% were HER2 positive.ConclusionsMdBC presented at a younger age than IDC, had a higher histological grade, larger median size and less frequent regional lymph node involvement. Most MdBCs were triple-negative, whereas IDCs were predominantly luminal. Despite numerous aggressive pathological features of MdBC, its clinical outcome and overall prognosis are favorable.
Beneficial effect of pristimerin against the development of osteoporosis in ovariectomy-induced osteoporosis rats by the RANKL/TRAF6/NF-κB pathway
Authors: Xu Wei , Zhu Xiaodong , Chen Chao , Hu Ruixi , Li Yifan , Xu Ruijun , Li Zhikun 
Published: August 2019

IntroductionOsteoporosis is a major cause of bone fracture in post-menopausal women. We evaluated the effects of pristimerin treatment on ovariectomy-induced osteoporosis, and its possible molecular mechanism.Material and methodsRats were ovariectomised and biochemical markers of bone formation were determined from serum samples. The microarchitectures of bone tissues were analyzed via micro-CT scans and Western blotting assays. The cytotoxic effects of pristimerin, the differentiation of osteoclasts, and bone reabsorption were evaluated <i><i><i><i>in vitro</i></i></i></i> using RAW 264.7 cells.ResultsTreatment with pristimerin attenuated changes in markers of bone formation and reabsorption such as creatine kinase (CK), alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), collagen type I fragments (CTX), bone Gla-protein (BGP), and osteocalcin (OC) in the serum of ovariectomised rats. It also appeared to restore the microarchitecture of bone tissue. The expression levels of TNF receptor-associated factor 6 (TRAF-6), nuclear factor k light chain enhancer of activated B cells (NF-κB p65), and receptor activator of nuclear factor-κB ligand (RANKL) protein were significantly lower, while those of Akt and PI3K were significantly higher, in the bone tissues of the pristimerin-treated group than in negative controls. Pristimerin had no cytotoxic effect on RAW 264.7 cells and reduced the differentiation of osteoclasts, bone reabsorption, and translocation of p65 in RANKL-stimulated RAW 264.7 cells <i><i><i><i>in vitro</i></i></i></i>.ConclusionsPristimerin reduces the effects of osteoporosis by restoring the altered RANKL/TRAF-6/NF-κB pathway in ovariectomised rats.
Asymmetry of dominant and non-dominant shoulders in university level men and women volleyball players
Authors: Zuzgina Olga , Wdowski Maximilian M. 
Published: August 2019

PurposeVolleyball involves repetitive forceful actions predominantly of one arm, which could eventually lead to an injury or shoulder pathology. The aim of the study was to compare the range of motion and strength in the dominant and non-dominant shoulders of university level volleyball players, with the objective of examining any differences between sexes.MethodsA total of 19 university level volleyball players (9 men: 81.3 ± 8.0 kg, 21 ± 1 years; 10 women: 66.0 ± 8.2 kg, 19 ± 1 years) participated. The passive internal and external range of motion of the dominant and non-dominant spiking shoulders were measured with a goniometer. The shoulder strength tests were performed on an isokinetic dynamometer at
the speed of 60°/s in the concentric mode of contraction. Shoulder internal and external rotator concentric strength, range of motion, and internal/external rotation strength ratios were tested between arm dominance and sex with the use of 2-way mixed design ANOVA.ResultsInternal and external rotation strength was asymmetrical in both men and women, in favour of the dominant side (<i>p</i> < 0.05). Both men and women displayed asymmetrical external/internal ratios (<i>p</i> < 0.05), with greater ratios present in the non-dominant side.ConclusionsUniversity level men and women volleyball players exhibit similar levels of significant asymmetry in the internal/external rotation strength between dominant and non-dominant spiking arms. Furthermore, subject-specific responses in strength asymmetries suggest further investigation at the individual level. Isokinetic shoulder screening could
be used to reveal information about possible risk factors for shoulder injuries.
Validity and reliability of the Polish version of the Academic Motivation Scale: a measure of intrinsic and extrinsic motivation and amotivation
Authors: Ardeńska Magdalena , Ardeńska Agnieszka , Tomik Rajmund 
Published: August 2019

BackgroundThe Academic Motivation Scale (AMS) is a measure of motivation in education. The AMS is based on the self-determination theory, which subdivides motivation into amotivation, extrinsic motivation and intrinsic motiva-tion. The main purpose of this study was to examine the validity and reliability of the Polish version of the AMS and to identify motivation to study of Polish university students.Participants and procedureThe first sample consisted of 1592 Polish university students (653 males, 939 females) majoring in physical education, physiotherapy, tourism and recreation, sport or sport and tourism management. The second sample consisted of 49 Polish university students (13 males, 36 females) of tourism and recreation. The AMS was vali-dated using exploratory and confirmatory factor analysis. Cronbach’s α was used to estimate reliability and internal consistency of the scale.ResultsThe AMS showed adequate levels of internal consistency (Cronbach α values above .78) and temporal stability (mean test-retest correlation = .88). Additionally, the fit indices of CFA were satisfactory (χ2/df = 4.95, GFI = .927, AGFI = .910, RMSEA = .050). Female students scored higher than males on four motivation subscales and low-er on amotivation.ConclusionsThe results confirmed the original seven-factor and 28-item structure of the Polish version of the AMS. The re-sults support the use of the Polish version of the AMS as a tool for assessing university students’ motivation.
Preliminary development of the Vietnamese Marital Satisfaction Scale (MSS-VN): a pilot study using a Vietnamese intellectual sample
Authors: Trinh Linh , Phan Hanh Thi 
Published: August 2019

BackgroundThe objective of the present study was to develop a scale to measure marital satisfaction within a Vietnamese context (Vietnamese Marital Satisfaction Scale – MSS-VN). Due to the lack of in-depth studies in Vietnam on marital satisfaction, as well as a paucity of specialized Vietnamese context measurement tools in this field, the marital satisfaction dimensions of the MSS-VN were based on extant research literature and the social-cultural context of Vietnamese intellectual couples.Participants and procedureA group of 10 Vietnamese intellectuals (ages 28 to 43 years, five males/five females) were used to vet the MSS-VN questions during the question development phase of the study. The final version of the MSS-VN was administered to a convenience sample consisting of 144 male and 145 female Vietnamese intellectuals (age 22 to 50 years, M = 31.60, SD = 5.40). Analysis involved tests of reliability and validity (internal consistency, content validity, and convergent validity).ResultsThe results in the exploratory factor analysis of the MSS-VN indicated the maintenance of 33 items, distributed in five factors: emotional support, division of responsibilities and housework, child-rearing, decision making and financial management, and cohesion. The convergent validity showed rather strong correlation between the final scale solution and the sub-scale “dyadic satisfaction” from the Dyadic Adjustment Scale of Spanier.ConclusionsThe MSS-VN was considered satisfactory for the proposed intent of developing a measure of marital satisfac-tion within a Vietnamese context, with consistency for application in other studies on Vietnamese intellectual’s marital satisfaction; however, due to the limitation of the convenience sample, further evidence on the valida-tion of the MSS-VN is required.
Risankizumab in the treatment of psoriasis – literature review
Authors: Banaszczyk Katarzyna 
Published: August 2019

Risankizumab is a humanized, monoclonal antibody directed against subunit p19 of interleukin 23 (IL-23). In February 2019, risankizumab was approved for the treatment of moderate to severe psoriasis. The aim of the work is to collect up-to-date information on risankizumab and present its mechanism of action and recent clinical trials in which it was applied. This work also compares the mechanisms of action of risankizumab and ustekinumab and their importance in the treatment of psoriasis and describes the role of IL-23 in the etiopathogenesis of psoriasis. The work also refers to the effectiveness of risankizumab treatment and its safety profile. The results of molecular and histological studies that show changes in psoriatic skin after risankizumab treatment are also described.