bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-Peptide Suppression During Insulin Infusion in the Extremely Preterm Infant Is Associated With Insulin Sensitivity
Authors: Hellström William , Hansen-Pupp Ingrid , Hellgren Gunnel , Engström Eva , Stigson Lennart , Sävman Karin , Ley David , Löfqvist Chatarina 
Published: May 2019

AbstractContextLittle is known about the individual response of glucose-regulating factors to administration of exogenous insulin infusion in extremely preterm infants.ObjectiveTo evaluate longitudinal serum concentrations of insulin, C-peptide, and plasma glucose levels in a high-frequency sampling regimen in extremely preterm infants treated with insulin because of hyperglycemia.DesignProspective longitudinal cohort study.SettingTwo university hospitals in Sweden between December 2015 and September 2016.Patients and InterventionSerum samples were obtained from nine extremely preterm infants, gestational age between 22 (+3) and 26 (+5) weeks (+ days), with hyperglycemia (plasma-glucose >10 mmol/L) at the start of insulin infusion, at 12, 24, and every 24 hours thereafter during ongoing infusion, and 12, 24, and 72 hours after the end of insulin infusion.Main outcome measuresLongitudinal serum concentrations of insulin and C-peptide and plasma glucose levels.ResultsDuring insulin infusion, the serum C-peptide concentrations decreased compared with at start of infusion (P = 0.036), and then increased after ending the infusion. Individual insulin sensitivity based on the nonfasting plasma glucose/insulin ratio at the start of insulin infusion correlated with the initial decrease in serum ΔC-peptide[after 12h] (P = 0.007) and the degree of lasting decrease in serum ΔC-peptide[after end of infusion] (P = 0.015).ConclusionExogenous insulin infusion suppressed the C-peptide concentration to individually different degrees. In addition, the effect of insulin infusion on β cells may be linked to individual insulin sensitivity, where a low insulin sensitivity resulted in a more pronounced decrease in C-peptide during insulin infusion.
Impaired Fasting Glucose and Chronic Kidney Disease, Albuminuria, or Worsening Kidney Function: A Secondary Analysis of SPRINT
Authors: Bigotte Vieira Miguel , Neves João Sérgio , Leitão Lia , Baptista Rute Baeta , Magriço Rita , Viegas Dias Catarina , Oliveira Ana , Carvalho Davide , Mc Causland Finnian R 
Published: May 2019

Abstract

Purpose
Diabetes mellitus is a risk factor for the development and progression of chronic kidney disease (CKD). However, the association of prediabetes with adverse kidney outcomes is uncertain.

Methods
We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), including 9361 participants without diabetes at baseline. We categorized participants according to fasting glucose level as having impaired fasting glucose [≥100 mg/dL (≥5.6 mmol/L)] or normoglycemia [&lt;100 mg/dL (&lt;5.6 mmol/L)]. Unadjusted and adjusted proportional hazards models were fitted to estimate the association of impaired fasting glucose (vs normoglycemia) with a composite outcome of worsening kidney function [≥30% decrease in estimated glomerular filtration rate (eGFR) to &lt;60 mL/min/1.73 m2 in participants without baseline CKD; ≥50% decrease in eGFR or need for long-term dialysis/kidney transplantation in participants with CKD] or incident albuminuria (doubling of urinary albumin/creatinine ratio from &lt;10 mg/g to &gt;10 mg/g). These outcomes were also evaluated separately and according to CKD status at baseline.

Results
Participants’ mean age was 67.9 ± 9.4 years, 35.5% were female, and 31.4% were black. The median follow-up was 3.3 years, and 41.8% had impaired fasting glucose. Impaired fasting glucose was not associated with higher rates of the composite outcome [hazard ratio (HR): 0.97; 95% CI: 0.8 to 1.16], worsening kidney function (HR: 1.02; 95% CI: 0.75 to 1.37), or albuminuria (HR: 0.98; 95% CI: 0.78 to 1.23). Similarly, there was no association of impaired fasting glucose with outcomes according to baseline CKD status.

Conclusions
Impaired fasting glucose at baseline was not associated with the development of worsening kidney function or albuminuria in participants of SPRINT.
Necropolitics, Postmortem/Transmortem Politics, and Transfeminisms in the Sexual Economies of Death
Authors: Valencia Sayak , Zhuravleva Olga Arnaiz 
Published: May 2019

AbstractThis article proposes two specific interventions, utilizing a critical transfeminist positioning to critique a transexclusionary perspective in writing and research on the crucial problem of necropolitics and the murder of women in Mexican society: (1) the term postmortem/transmortem politics, to reflect on the forms that imagination and political practice developed inside a Mexican trans community to deal with the necropolitics that murders trans and cis women on an everyday basis with complete impunity—in this sense, the process of mobilization, here called postmortem/transmortem, builds bridges of transfeminist alliance since it reactivates and embodies struggles against femicide and transfemicide from communities of care and vulnerability; and (2) the goals of the transfeminist movement as a source of feminist repolitization and greater inclusivity for the subject of feminisms, considering those subjects left outside or energetically moved away from the neoliberal reconversion of the critical devices of the white heterosexual and institutional feminisms that we know today as gender politics or “women's politics,” managed and operated by the state.
DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis
Authors: Rosas-Salvans Miquel , Scrofani Jacopo , Modol Aitor , Vernos Isabelle 
Published: May 2019

ABSTRACT
Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex generates spindle inward forces and plays a major role in spindle pole focusing. The dynactin complex regulates many dynein functions, increasing its processivity and force production. Here, we show that DnaJB6 is a novel RanGTP-regulated protein. It interacts with the dynactin subunit p150Glued (also known as DCTN1) in a RanGTP-dependent manner specifically in M-phase, and promotes spindle pole focusing and dynein force generation. Our data suggest a novel mechanism by which RanGTP regulates dynein activity during M-phase.
Proximity-dependent biotinylation mediated by TurboID to identify protein–protein interaction networks in yeast
Authors: Larochelle Marc , Bergeron Danny , Arcand Bruno , Bachand François 
Published: May 2019

ABSTRACT
The use of proximity-dependent biotinylation assays coupled to mass spectrometry (PDB-MS) has changed the field of protein–protein interaction studies. However, despite the recurrent and successful use of BioID-based protein–protein interactions screening in mammalian cells, the implementation of PDB-MS in yeast has not been effective. Here, we report a simple and rapid approach in yeast to effectively screen for proximal and interacting proteins in their natural cellular environment by using TurboID, a recently described version of the BirA biotin ligase. Using the protein arginine methyltransferase Rmt3 and the RNA exosome subunits, Rrp6 and Dis3, the application of PDB-MS in yeast by using TurboID was able to recover protein–protein interactions previously identified using other biochemical approaches and provided new complementary information for a given protein bait. The development of a rapid and effective PDB assay that can systematically analyze protein–protein interactions in living yeast cells opens the way for large-scale proteomics studies in this powerful model organism.
Effects of Virtual Reality training on medical students’ learning motivation and competency
Authors: Sattar Mian Usman , Palaniappan Sellappan , Lokman Asiah , Hassan Atif , Shah Nauman , Riaz Zurabia 
Published: May 2019

Objectives: To determine the need of contemporary immersive approaches (Virtual Reality) in teaching and training at medical sector. The main objective of this study was to explore the effects of text, video and immersive technologies learning methodologies for participants’ learning in public and private medical colleges and universities of Pakistan.
Methods: In this quantitative research 87 medical students of 4th year from three public and five private medical colleges and universities participated. A laparoscopy operation was selected in consultation with senior medical consultants for this experiment. The experimental material was arranged in virtual reality, video and text based learning. At completion of each of which, participants completed a questionnaire about learning motivation and learning competency through the different mediums.
Results: Statistical t-test was selected for the analysis of this study. By comparing the mean values of virtual reality, video, and text based learning methodologies in medical academics; result of virtual reality is at top of others. All performed model are statistically significant (P=0.000) and results can be applied at all population.
Conclusion: Through this research, we contribute to medical students learning methodologies. In medical studies, both theoretical and practical expertise has a vital role, while repetition of hands-on practice can improve young doctors’ professional competency. Virtual reality was found best for medical students in both learning motivation and learning competency. Medical students and educationist may select virtual reality as new learning methodology for curriculum learning.
doi: https://doi.org/10.12669/pjms.35.3.44
How to cite this:Sattar MU, Palaniappan S, Lokman A, Hassan A, Shah N, Riaz Z. Effects of Virtual Reality training on medical students’ learning motivation and competency. Pak J Med Sci. 2019;35(3):852-857. doi: https://doi.org/10.12669/pjms.35.3.44
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Solving Zero-Sum Games Using Best-Response Oracles with Applications to Search Games
Authors: Hellerstein Lisa , Lidbetter Thomas , Pirutinsky Daniel 
Published: May 2019

How to Choose Between Exponentially Many Strategies In “Solving Zero-Sum Games Using Best-Response Oracles with Applications to Search Games,” L. Hellerstein, T. Lidbetter, and D. Pirutinsky consider zero-sum games between a minimizer and a maximizer, where the number of pure strategies of the minimizer is exponential in the number of pure strategies of the maximizer. Such games are frequent in the search-games literature. Solving them with standard algorithms typically takes exponential time. The authors show how to compute (approximate) solutions in polynomial time, provided that there is a polynomial time (approximate) algorithm solving the best-response problem: given a mixed (randomized) strategy of the maximizer, what is a best response of the minimizer? The paper presents both a learning approach using weight updates and an approach of solely theoretical interest based on the ellipsoid algorithm. The learning approach performs well experimentally compared with approaches in the literature. The results are applied to obtain new algorithms for solving specific search games.
Editorial
Authors: Soares Adriana Benevides , Tsallis Alexandra Cleopatre , Mendes Deise Maria Fernandes , Moraes Marcia , Barros Rita Maria Manso de 
Published: May 2019

Adriana Benevides Soares, Alexandra Cleopatre Tsallis, Deise Maria Fernandes Mendes, Marcia Moraes, Rita Maria Manso de Barros
Prematuridade e outros fatores de risco adicional ao desenvolvimento perceptomotor e sua influência no desempenho escolar
Authors: Pereira Débora Morais , Araújo Rita De Cássia Tibério , Braccialli Ligia Maria Presumido 
Published: May 2019

Considerando que múltiplos fatores podem afetar o desempenho de alunos em tarefas acadêmicas, foram objetivos deste estudo: a) avaliar o desempenho de alunos do Ensino Fundamental sob parâmetros da performance em testes padronizados; b) identificar a influência da ocorrência de nascimento pré-termo e/ou com baixo peso e da presença de deficiência sobre as habilidades avaliadas nos testes. Participaram 77 alunos do 2º ano de uma escola pública. Sete deles nasceram prematuros e/ou com baixo peso e três foram apontados por seus responsáveis como apresentando deficiência. Para a coleta de dados foram utilizados o Teste do Desenvolvimento da Integração Visuo-Motora (Beery VMI) e o Teste de Desempenho Escolar (TDE) e um questionário desenvolvido para caracterização dos participantes. Em relação ao desempenho dos alunos no Beery VMI as médias de pontuações encontradas foram: 18 na avaliação da integração visuo-motora, 21 na avaliação de percepção visual e 22 no teste de coordenação motora. Em relação ao desempenho no TDE, a média de acertos foi: 13 no subteste de escrita, 8 na avaliação de aritmética e 46 no subteste de leitura. Constatou-se correlação positiva entre a habilidade de integração visuo-motora e a habilidade acadêmica avaliada nas tarefas de escrita, aritmética e leitura (p≤ 0,05). A presença de deficiência e a ocorrência de prematuridade ou baixo peso ao nascimento acentuaram as correlações.
Maioridade penal no Brasil e na Espanha: o pêndulo punitivo sobre os adolescentes infratores | Criminal majority in Brazil and Spain: the punitive pendulum under the juvenile offenders
Authors: Peixoto Roberto Bassam 
Published: May 2019

A abordagem recai em discussão acerca da redução da maioridade penal na Espanha e no Brasil, com base nos dados e estudos realizados durante o estágio doutoral na Universidade Autônoma de Barcelona, sendo fruto da pesquisa junto ao Doutorado em Serviço Social da Universidade do Estado do Rio de Janeiro (Uerj). Assim, busca-se a compreensão das alternativas para a privação de liberdade: princípio educativo x punição, reforçando os conceitos e a necessidade da luta em defesa da não punição e encarceramento em massa da juventude. Nesse contexto, são apresentadas discussões e argumentos contrários à redução da maioridade penal, com demonstração de dados e estudos nos dois países, em que se evidencia que a maioridade penal no Brasil e na Espanha abarca um pêndulo punitivo sobre os adolescentes infratores.Palavras-Chave: redução da maioridade penal; medidas socioeducativas; adolescentes infratores; socioeducação; políticas públicas; Brasil; Espanha. Abstract – The approach falls on the discussion about the reduction of the penal age in Spain and Brazil, based on the data obtained during the doctoral training at the Autonomous University of Barcelona as a result of the research with the PhD in Social Work of the State University of Rio de Janeiro - UERJ, and seeks to understand the alternatives to deprivation of liberty: an educational principle x punishment. It reinforces the concepts and the necessity of the fight in defense of the non-punishment and mass incarceration of the youth. In this context it is presented the discussions and arguments against the reduction of the criminal majority, with presentation of data and studies in both countries, where it shows that the criminal majority in Brazil and Spain covers a punitive pendulum under the juvenile offenders.Keywords: Reduction of the Penal Majority; Educational measures; Adolescents Offenders; Socioeducation; Public policy; Brazil; Spain.
Menino veste azul, menina veste rosa? Violência e divisão sexual do trabalho | Boys wear blue, girls wear pink? Violence and sexual division of labor
Authors: Parizotto Natália Regina 
Published: May 2019

O presente artigo procura problematizar a relação entre divisão sexual do trabalho e subalternização das mulheres. É fruto de uma pesquisa mais ampla, de base empírica e documental, acerca da implementação da Lei Maria da Penha pelo Poder Judiciário na cidade de São Paulo. Aborda a influência da divisão sexual do trabalho na trajetória de mulheres em situação de violência doméstica de gênero.Palavras-Chave: divisão sexual do trabalho; violência doméstica de gênero; trabalho feminino. Abstract – The present article tries to problematize the relation between the sexual division of labor and the subalternization of women. It is the result of a broader empirical and documentary research on the implementation of the Maria da Penha Law by the Judiciary Power in the city of São Paulo. It addresses the influence of the sexual division of labor on the trajectory of women in situations of domestic violence of gender.Keywords: Sexual Division of Labor. Domestic violence of gender. Female work.
Clinical decision-making and its place in paramedic practice
Authors: Murdoch Samantha 
Published: May 2019

In the pre-hospital environment, paramedics are required to make clinical decisions, often rapidly to ensure correct treatment and care is provided. Decisions made by paramedics majorly impacts on the life, clinical outcome, safety, health and wellbeing of their patients. With the introduction of the Newly Qualified Paramedic Framework, it potentially has never been more pertinent to examine the decision-making process-an integral part of paramedicine.The implementation of the NQP framework has prompted an exploration into clinical decision making and its place in an ever-evolving profession. Through examination of theories and frameworks, this article aims to identify the underpinning evidence that enables a paramedic to reach a competent decision and the barriers experienced in the process.
El seguimiento de reglas ¿es la praxis de un sujeto? Wittgenstein y las ciencias sociales
Authors: Karczmarczyk Pedro 
Published: May 2019

En el presente trabajo contrastamos la interpretación de las reflexiones de Wittgenstein sobre el seguimiento de reglas como la "práctica de un sujeto", con una interpretación alternativa que ve en los participantes de los juegos de lenguaje los "sujetos de una práctica". Desarrollamos este punto a través de un análisis de algunas distinciones claves en los Cuadernos azul y marrón (acción significativa y hábito, etc.), que lleva a elucidar conceptos como "obediencia ciega" y "límite de la justificación". En la segunda parte intentamos mostrar que la lectura en términos de "la praxis de un sujeto" habilita una lectura hermenéutica de Wittgenstein en el campo de las ciencias sociales, mientras que la lectura en términos de "los sujetos de una práctica" realiza un conjunto de operaciones críticas cruciales, en particular su negativa a interpretar los fenómenos en términos de causas finales, que llevan a la afirmación de la objetividad de la realidad social, es decir, a la operación de definición del objeto científico a través de la cual se han constituido las ciencias hasta hoy conocidas. Señalaremos para concluir algunos puntos de contacto con las operaciones fundacionales del materialismo histórico.
La esencia poética de la obra de arte. Reflexiones en torno a Ser y tiempo y "El origen de la obra de arte"
Authors: Belgrano Mateo 
Published: May 2019

Este trabajo pretende analizar la caracterización por parte de Heidegger de la esencia de la obra de arte como "poética" en "El origen de la obra de arte". ¿Qué puede llegar a significar esto? ¿Se puede reducir la esencia de la obra de arte a un tipo de arte? Abordaremos este problema interpretativo fundamentalmente de Ser y tiempo,aunque también nos serviremos de la conferencia "Hölderlin y la esencia de la poesía". "Poético" se refiere a un ámbito más amplio que el del género literario, se refiere al espacio donde se da la verdad, entendida siempre como desocultación. La tesis por defender es que lo que Heidegger comprende por "poesía" en el ensayo sobre el arte es el lenguaje entendido como fuente de inteligibilidad o comprensibilidad, es decir, como aquello que permite al ente manifestarse como ente, abre el espacio de sentido que le permite mostrarse.
The transform of the ımage of woman to Snow White movies from Grimm Tales to millenium Cinema <p> Grimm Masallarından milenyum sinemasına Pamuk Prenses filmlerinde kadın imajının dönüşümü
Authors: Kızıler Emer Funda , Kerimustaoğlu Kübra 
Published: May 2019

The tale which is a narrative that hasn’t an author appeared as oral custom in the begining has become an important representative as an epic style in the written literatüre. The cinema which is qualified as the 7th art is a new art in comparison with the tale. And it comes forward as the most efficient and the most effective media of the modern World. Two important art , literature and cinema are linked to each other. The first goal of these arts is to show up mental behaviours of human and the realities of lives and to make it feel to the crowd of people.The Snow White, printed in 1812 by Grimm Brothers is adapted to ‘’the adventures of the snow White’’ and ‘’The snow White and the hunter’’ by Tarsem Singh and Rupert Sanders in 2012. Those versions have the common contents with the tale. The snow White is observed that it has a big change even if the directors hold the content of tale with regard to place and time. The transform of the image of woman will be searched as part of ‘the snow white’’ in those versions from the literature to the cinema.Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetBaşlarda sözlü gelenekte meydana çıkıp yazanı belli olmayan (anonim) bir anlatı türünün adı olan masal, daha sonra yazılı edebiyat içinde yer edinerek epik türün önemli bir temsilcisi haline gelmiştir. Yedinci sanat olarak nitelendirilen sinema ise yaklaşık yüzyıllık geçmişiyle, arkaik çağlardan günümüze kadar varlığını koruyan epik bir edebi tür olan masala göre daha yeni bir sanat dalı olup, (post)modern dünyanın en etkin ve etkili medyalarından biri olarak öne çıkar. İki önemli sanat dalı olan edebiyat ve sinema birbirlerine kaynaklık eder. İki sanat dalının öncelikli amacı; insan hayatının gerçeklerini, kişinin ruhsal hareketlerini gözler önüne sermek ve hitap edilen kitleye bunu hissettirmektir.Ünlü Alman Grimm Kardeşler tarafından derlenerek 1812’de basılan “Pamuk Prenses” (“Schneewitchen”) masalı, 2012 yılında peş peşe Tarsem Singh ve Rupert Sanders adlı iki ayrı yönetmen tarafından “Pamuk Prenses’in Maceraları” ve “Pamuk Prenses ve Avcı” adlarıyla sinemaya uyarlanmıştır. Bu uyarlamalar tematik açıdan genel hatlarıyla masalla ortak içeriğe sahip sayılır. Yönetmenler eserin içeriğine her ne kadar zaman ve mekan unsurları bakımından sadık kalsa da, Pamuk Prenses adlı ana kadın figürün 19. yüzyıldan günümüz milenyum dünyasına büyük bir değişikliğe uğradığı gözlenir. Medyalararası nitelikteki çalışmada; edebiyattan sinemaya yapılan bu uyarlamalarda Pamuk Prenses ekseninde kadın imajının dönüşümü araştırılacaktır.
Geometric morphometrics of wing venation to differentiates new species of Scaura Schwarz populations (Hymenoptera: Apidae: Meliponini)
Authors: Nogueira David Silva , Mahlmann Thiago , Teixeira Juliana Stephanie Galaschi , Oliveira Marcio Luiz de , Roubik David Ward 
Published: May 2019

Scaura Schwarz, 1938 is a small Neotropical genus of stingless bees widely distributed in Brazil. The new species of Scaura is a widespread species, and its wide distribution may suggest that it is a species complex. In order to differentiate populations that could compose cryptic species, we studied the wing venation variation using geometric morphometrics in 56 workers, 23 of these from remaining of Atlantic Forest in Ceará state and 33 from the Amazon region. Bees from Atlantic Forest differed of the bees from Amazon region, corresponding to 38.05% of total variation (principal components analysis), 100% of canonical variation and 52.93% of canonical variation between localities, with significant difference between populations in discriminant function analysis (p<0.001). The results suggest that the Atlantic Forest bees may be a new species. However, it is necessary more detailed morphological studies, and/or a molecular analysis to confirm this possibility.