bluuebunny/crossref_metadata_2025_split huggingface dataset:
Travel time prediction in transport and logistics
Authors: Li Xia , Bai Ruibin , Siebers Peer-Olaf , Wagner Christian 
Published: July 2019

Purpose
Many transport and logistics companies nowadays use raw vehicle GPS data for travel time prediction. However, they face difficult challenges in terms of the costs of information storage, as well as the quality of the prediction. This paper aims to systematically investigate various meta-data (features) that require significantly less storage space but provide sufficient information for high-quality travel time predictions.

Design/methodology/approach
The paper systematically studied the combinatorial effects of features and different model fitting strategies with two popular decision tree ensemble methods for travel time prediction, namely, random forests and gradient boosting regression trees. First, the investigation was conducted using pseudo travel time data that were generated using a pseudo travel time sampling algorithm, which allows generating travel time data using different noise processes so that the prediction performance under different travel conditions and noise characteristics can be studied systematically. The results and findings were then further compared and evaluated through a real-life case.

Findings
The paper provides empirical insights and guidelines about how raw GPS data can be reduced into a small-sized feature vector for the purposes of vehicle travel time prediction. It suggests that, add travel time observations from the previous departure time intervals are beneficial to the prediction, particularly when there is no other types of real-time information (e.g. traffic flow, speed) are available. It was also found that modular model fitting does not improve the quality of the prediction in all experimental settings used in this paper.

Research limitations/implications
The findings are primarily based on empirical studies on limited real-life data instances, and the results may lack generalisabilities. Therefore, the researchers are encouraged to test them further in more real-life data instances.

Practical implications
The paper includes implications and guidelines for the development of efficient GPS data storage and high-quality travel time prediction under different types of travel conditions.

Originality/value
This paper systematically studies the combinatorial feature effects for tree-ensemble-based travel time prediction approaches.
Detecting amplicons of loop‐mediated isothermal amplification
Authors: Shirato Kazuya 
Published: July 2019

AbstractLoop‐mediated isothermal amplification (LAMP) assays are used to detect diverse pathogens. Initially, LAMP amplicons were detected using electrophoresis; later, real‐time monitoring based on turbidity was developed to overcome the problem of contamination with environmental DNA. Recently, real‐time monitoring of fluorescence signals using a quenching primer and probe has improved the reliability of amplification signals. Here, methods of detecting LAMP amplicons are reviewed.
Getting Ahead: Extraction of DNA from Skeletonized Cranial Material and Teeth
Authors: Edson Suni M. 
Published: July 2019

AbstractBetween 1990 and 2018, the Defense POW/MIA Accounting Agency submitted 2177 cranial elements and 1565 teeth to the Armed Forces Medical Examiner System—Armed Forces DNA Identification Laboratory for DNA testing. In an effort to identify missing United States service members, materials were recovered from wartime losses inclusive of World War II, the Korean War, and Southeast Asia. Using four different DNA extraction protocols, DNA testing was performed using mitochondrial DNA Sanger sequencing, modified AmpFlSTR® Yfiler™, AmpFlSTR® MiniFiler™, PowerPlex® Fusion, or Next Generation Sequencing. This paper aims to provide optimal strategies for the DNA testing of skeletonized cranial materials. Cranial elements produced the most consistent results in Sanger sequencing using an organic purification; however, teeth were most successful for the same platform with an inorganic purification. The inverse is true for STR testing of cranial bones. Of the cranial elements, the temporal provided the most consistent results.
Sociodemographic, Clinical, and Therapeutic Aspects of Penitentiary Psychiatric Consultation: Toward Integration Into the General Mental Health Services
Authors: Arnau Francisco , García‐Guerrero Julio , Benito Ana , Vera‐Remartínez Enrique J. , Baquero Abel , Haro Gonzalo 
Published: July 2019

AbstractThe characteristics of mental disorders, as well as deficiencies in their treatment, must be properly defined. This was a prospective, longitudinal, observational study, in which all men referred to a penitentiary psychiatric consultation of three penitentiary centers in Spain were invited to participate. Those who consented to participation (1328) were interviewed at the baseline timepoint and at intervals for up to 3 years. The presence of mental disorders was high: 68.2% had a cluster B personality disorder, 14% had an affective and/or anxiety disorders, 13% had schizophrenia, and over 80% had a dual disorder. Polypharmacy was the norm. Moreover, the health care received in prison did not match that provided in the community in terms of quantity and quality. These results should help to facilitate the design of mental healthcare provision for prisoners, focusing on both the most frequent patient profiles and equality of care.
Translation, cross‐cultural adaptation and validation of Nepali version of Health Assessment Questionnaire‐Disability Index in rheumatoid arthritis patients from Nepal
Authors: Vaidya Binit , Joshi Rakshya , Lama Lhakpa Dolma , Nakarmi Shweta 
Published: July 2019

AbstractObjectiveTo translate, cross‐culturally adapt and validate the Health Assessment Questionnaire‐Disability Index (HAQ‐DI) in Nepali language (Nepali HAQ).MethodsTranslation was done fulfilling the methodological standards described by Beaton. Comprehensibility testing of the preliminary version was done in 50 rheumatoid arthritis (RA) patients, and a prefinal version was prepared after making changes in the original version to maintain the equivalence with the target version. Psychometric testing was done in another group of 127 rheumatoid patients to test for content validity and reliability. Construct validity was tested with visual analog score (VAS) and numeric rating scales (NRS) for pain and stiffness.ResultsNepali HAQ was comprehensible in >95% of patients. Reliability testing showed an intraclass coefficient for overall Nepali HAQ of 0.76, ranging from 0.71 to 0.95. The internal consistency was acceptable with a Cronbach's alpha of .92. Construct validity was also acceptable with a moderate correlation between Nepali HAQ and VAS and NRS.ConclusionsNepali HAQ is a comprehensible, reliable and valid tool for evaluation of the functional status of Nepalese patients with RA and should be implemented in clinical care and research settings.
Gender differences in the rat corpus callosum: An ultrastructure study
Authors: Al Qattan Duaa , Shatarat Amjad , Alzghoul Loai , Khaled Aya , Abdallah Ala , ELBeltagy Maha 
Published: July 2019

AbstractSexual dimorphism exists at all levels of the nervous system, from genetic, anatomical and system levels. The sexual dimorphism in the axonal content of the corpus callosum (CC) has always been controversial; hence, the aim of this study was to analyse the differences in total, myelinated and unmyelinated axons density of various regions of the CC between male and female rats. To assess that, six pairs of adult male and female rats were perfused and the CC was removed and sectioned. Four sections from different subregions of the corpus callosum that represent the genu, anterior body, posterior body, and splenium, were stained, and electron microscopic images were captured using stereological guidelines. Later, the axons density for each subregion was calculated and compared between males and females. The findings of the present study indicated region‐specific differences in the myelinated, unmyelinated or the ratio of myelinated/total axons in the CC between male and female rats.
Functional outcomes of an integrated Parkinson's Disease Wellbeing Program
Authors: Horne Jeremey T. , Soh Derrick , Cordato Dennis J. , Campbell Megan L. , Schwartz Raymond S. 
Published: July 2019

AbstractIntroductionThere is growing evidence that exercise provides benefit in treating motor and non‐motor symptoms in Parkinson's disease (PD).ObjectivesThe aims of this study were to determine (a) whether a 5‐week PD‐specific program resulted in sustained physical and psychosocial benefits, and (b) the relationship between patient characteristics, exercise, falls and physical and psychosocial parameters.DesignSingle‐centre prospective observational study.MethodsA total of 135 consecutive patients with mild‐to‐moderate PD underwent a 5‐week PD‐specific education and exercise program from August 2013 to March 2015. Gait, mobility and psychosocial measures were compared at baseline, 6 weeks and 12 months.ResultsSignificant improvements in physical (walking distance in 2 minutes, number of “Sit To Stands” in 30 seconds, time in seconds taken to “Timed Up and Go,” fast gait velocity over 10 m, Berg Balance Scale [BBS]) and psychosocial (quality of life (QoL) [PDQ‐39], depression and anxiety [DASS‐21], and fatigue [PSF‐16]) measures were seen at 6 weeks (all P < .01) with physical improvements sustained at 12 months (all P < .001). The number of patients at 12 months with ≥1 fall reduced from 66% to 33%, and the number not exercising reduced from 42% to 21%. A lack of exercise correlated with ≥1 fall at 12 months (OR 3.39, 95% CI 1.36‐8.39, P = .009). It was also associated with poorer balance and psychosocial parameters at 12 months (all P < .05).ConclusionsPatients recruited into a 5‐week Parkinson's disease education and exercise program achieved significant 12‐month benefits in physical but not psychosocial measures. Patients with ≥1 fall post‐treatment were less likely to have been exercising at 12‐month follow‐up.
Boredom begets boredom: An experience sampling study on the impact of teacher boredom on student boredom and motivation
Authors: Tam Katy Y. Y. , Poon Cyanea Y. S. , Hui Victoria K. Y. , Wong Christy Y. F. , Kwong Vivian W. Y. , Yuen Gigi W. C. , Chan Christian S. 
Published: July 2019

BackgroundBoredom is a common complaint among students. Boredom was previously found to be negatively associated with academic outcomes, such as academic motivation, strategies, and achievement. It is of interest to understand students’ in‐class boredom, especially factors that might exacerbate it.AimsThe current study examines the influence of teacher's boredom on students’ in‐class boredom and learning experience. It aims to understand the relationship between teacher boredom, students’ perceived teacher boredom, student boredom, and student learning motivation.SampleA total of 437 students (54.8% female, MAge = 14.5 years, SD = 1.6) and 17 of their teachers (29.4% female, 76.5% 40 years old or below) participated in the study.MethodsWe conducted an experience sampling study, in which participants completed a 2‐week diary. Data were analysed using multilevel modelling.Results and ConclusionsResults from multilevel modelling of 2,675 post‐class evaluations indicated that teacher boredom was negatively associated with students’ motivation. However, the relationship between teacher boredom and students’ perceived teacher boredom was not significant, suggesting that students did not accurately perceive whether their teacher was bored. Results from indirect effect analysis further revealed that students’ perception of teacher boredom predicted student learning motivation through student boredom. In other words, perceiving teachers being bored promoted students’ own feeling of boredom, which in turn reduced their learning motivation. Together, these results indicate that when a teacher is bored in class, or when students perceive that their teacher is bored, students would have lower learning motivation.
Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open‐label phase 2 trial
Authors: Tamura Kenji , Hasegawa Kosei , Katsumata Noriyuki , Matsumoto Koji , Mukai Hirofumi , Takahashi Shunji , Nomura Hiroyuki , Minami Hironobu 
Published: July 2019

AbstractNivolumab is a human monoclonal antibody against the immune checkpoint receptor programmed death‐1, inhibiting binding to programmed death‐ligand 1 or 2 (PD‐L1 or PD‐L2). This phase 2 study evaluated the efficacy and safety of nivolumab in patients with advanced/recurrent uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma (STS). Patients received nivolumab 240 mg at 2‐week intervals. Primary endpoint was objective response rate; secondary endpoints included overall survival, progression‐free survival, and safety. PD‐L1 expression and microsatellite‐instability (MSI) status were analyzed as potential efficacy biomarkers. Objective response rate was 25%, 23%, and 0% in patients with cervical cancer (n = 20), corpus cancer (n = 22), and STS (n = 21), respectively. The lower 80% confidence intervals of objective response rates in patients with cervical or corpus cancer exceeded the threshold rate (5%); the primary endpoint was met in cervical and corpus cancer, but not in STS. Median progression‐free survival was 5.6, 3.4, and 1.4 months, and 6‐month overall survival was 84%, 73%, and 86% in cervical cancer, corpus cancer, and STS, respectively. The objective response rate was higher in patients with cervical cancer with PD‐L1‐positive (n = 5/15; 33%) versus PD‐L1‐negative (n = 0/5; 0%) tumors. The two patients with corpus cancer classified as MSI‐high responded; the six patients classified as microsatellite stable did not respond. Overall, nivolumab showed acceptable toxicity in all cohorts, with evidence of clinical activity in uterine cervical or corpus cancer, but not in STS. PD‐L1 expression in cervical cancer and MSI‐high in corpus cancer may predict clinical activity of nivolumab in these cancers.
Knowing Who You Are for Not Feeling Lonely? A Longitudinal Study on Identity and Loneliness
Authors: Kaniušonytė Goda , Truskauskaitė‐Kunevičienė Inga , Žukauskienė Rita , Crocetti Elisabetta 
Published: July 2019

In adolescence, both identity concerns and feelings of loneliness are of utmost importance to the experiences of young people. Yet, a theoretically grounded hypothesis that identity and loneliness are developmentally related has never been tested. Thus, the aim of this study was to disentangle the longitudinal associations between identity processes in educational and interpersonal domains and loneliness in adolescence. The sample consisted of 632 Lithuanian adolescents (53.2% girls; Mage = 14.32; SDage = 1.09) participating in a four‐wave study with 6‐month intervals between assessments. Cross‐lagged analyses revealed reciprocal associations between identity processes and loneliness in the educational domain and unidirectional effects of adolescents' reconsideration of commitment on loneliness in the interpersonal domain.
Secondary sphincter repair for anal incontinence following obstetric sphincter injury: functional outcome and quality of life at 18 years of follow‐up
Authors: Barbosa M. , Glavind‐Kristensen M. , Moller Soerensen M. , Christensen P. 
Published: July 2019

AbstractAimSecondary sphincter repair has been the conventional management of anal incontinence (AI) when a structural defect in the sphincter is recognized. However, disappointing long‐term results have contributed to a tendency towards an increasing use of alternative treatment methods. This study aimed to assess the long‐term functional outcomes following a secondary sphincter repair in women with AI after obstetric sphincter injury.MethodThis is a questionnaire study of women who underwent a secondary sphincter repair in Denmark between January 1990 and December 2005. Patients were identified through the Danish National Patient Registry. Functional outcomes were assessed by a self‐administered questionnaire in 2010 and 2018. Primary outcomes were Wexner and St. Mark's scores. Impact on quality of life was assessed using the Fecal Incontinence Quality of Life Scale.ResultsFunctional outcome was assessed in 370 women in 2010 and 255 women in 2018. At 18.3 [interquartile range (IQR 15.0–22.0)] years of follow‐up, the mean ± SD Wexner score was 8.8 ± 4.8 and the mean St. Mark's score was 11.7 ± 5.0. Flatus incontinence was the most frequent symptom, reported by 97%. Incontinence for liquid and solid stools was reported by 75% and 54%, respectively. There were no significant changes in incontinence frequencies over time. Women with a Wexner score of ≥ 9 had a significantly lower quality of life score in all domains than did women with a Wexner score of < 9 (P < 0.001).ConclusionAt long‐term follow‐up, few patients are fully continent following a secondary sphincter repair. However, it appears that the functional results remain stable at very long‐term follow‐up.
Towards the design of a blending system for precoloured fibres
Authors: Hemingray Caroline , Dean Louise , Westland Stephen 
Published: July 2019

AbstractIn order to create a commercial system for blending precoloured fibres that will appear visually solid once combined, it is necessary to understand the maximum colour difference required between the blend components. Based on this understanding, the lowest number of primaries required to populate a given colour gamut can be determined. A series of psychophysical experiments was carried out to explore the colour difference between fibre‐blend components and whether the resulting blended samples are perceived as visually solid. Experiments were carried out with loose stock fibre, yarn and knitted samples. Generally, it was found that the likelihood a blend appeared as visually solid increased as the average colour difference between the blend components, or primaries, decreased. The value of the mean colour difference at which 50% of participants viewed the blend as being visually solid was found to be 20.8, 20.5 and 18.0 for fibre, yarn and knitted samples, respectively. Consequently, it was found that it was more difficult to obtain a solid shade with the knitted form than with the loose stock fibre form.
The Effect of Hospital‐Physician Integration on Operational Performance: Evaluating Physician Employment for Cardiovascular Services
Authors: Zepeda E. David , Nyaga Gilbert N. , Young Gary J. 
Published: July 2019

ABSTRACTA dramatic change in the hospital industry is the increasing emphasis on linking provider payment to quality performance metrics. This is one of several considerations leading hospitals to employ physicians. Yet, there is little evidence regarding whether physician employment as a form of hospital‐physician integration leads to better operational performance. Using data from 201 California hospitals that experienced a total of 405,766 eligible opportunities to conform to external performance metrics (conformance quality) for treating patients in the cardiovascular service area, we empirically evaluated the relationship between physician employment and conformance quality. We also evaluated whether the presence of core capabilities in the hospital's cardiovascular service area complements or substitutes for physician employment. Findings suggest that physician employment is not only positively associated with conformance quality, but also associated with more consistent conformance quality. Moreover, the presence of core capabilities in the service area substitutes for physician employment. Theoretical, managerial, and policy implications are discussed.
Prospective multicenter international study on the outcomes of a newly developed self‐approximating lumen‐apposing metallic stent for drainage of pancreatic fluid collections and endoscopic necrosectomy
Authors: Teoh Anthony Yuen Bun , Bapaye Amol , Lakhtakia Sundeep , Ratanachu Thawee , Reknimitr Rungsun , Chan Shannon Melissa , Choi Hyun Jong , Gadhikar Harshal P. , Kongkam Pradermchai , Korrapati Sravan Kumar , Lee Yun Nah , Medarapalem Jahangeer , Ridtitid Wiriyaporn , Moon Jong Ho 
Published: July 2019

BackgroundA novel self‐approximating lumen‐apposing metallic stent (LAMS; Niti‐S Spaxus, Taewoong Medical, Gyeonggi‐do, Korea) has recently become available. The aim of the present study was to evaluate the outcomes for drainage of pancreatic fluid collections (PFC).MethodsThis was a prospective international multicentered study conducted in six high‐volume institutions across Asia. Consecutive patients suffering from pancreatic pseudocyst or walled‐off pancreatic necrosis (WOPN) requiring endoscopic ultrasonography‐guided drainage were recruited. Outcomes included technical and clinical success, adverse events, procedural events, interventions through the stent and recurrence rates.ResultsBetween August 2016 and November 2017, 59 patients were recruited to this study. Thirty‐nine patients (66.1%) had WOPN and mean (SD) size of PFC was 11.5 (5.1) cm. Technical and clinical success rates were 100%. Mean (SD) procedural time was 35.0 (17.2) minutes. Sixteen‐millimeter stents were used in 66.1% of the patients. Fifty‐four sessions of necrosectomy were carried out with the stent in situ in 17 patients. Stent‐related adverse event (AE) rate was 6.8%. Three patients (5.1%) suffered from bleeding after stenting and one required angiographic embolization. Two patients (3.4%) suffered from recurrence during a mean (SD) follow‐up time of 325.6 (355.5) days. There were no differences in outcomes between those with pseudocysts or WOPN except for the duration of hospital stay (P = 0.012).ConclusionUse of a self‐approximating LAMS for drainage of PFC was safe and effective. Endoscopic necrosectomy could be carried out through the stent with ease. The device was associated with a low rate of stent‐related AE.
Behavioural responses of the small hive beetle to volatile components of fermenting honeybee hive products
Authors: Hayes R. Andrew , Amos Brogan A. , Rice Steven J. , Baker Dalton K. , Leemon Diana M. 
Published: July 2019

AbstractThe small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is a significant pest of managed honeybees in the USA and eastern Australia. The beetle damages hives by feeding on hive products and leaving behind fermented wastes. The beetle is consistently associated with the yeast Kodamaea ohmeri (Etchells & Bell) Yamada et al. (Saccharomycetales: Metschnikowiaceae), and this yeast is the presumed agent of the fermentation. Previous work has noted that the small hive beetle is attracted to volatiles from hive products and those of the yeast K. ohmeri. In this study, we investigated how the volatile compounds from the fermenting hive products change depending upon the source of the hive material and also how these volatiles change through time. We used gas chromatography–mass spectrometry and choice‐test behavioural assays to investigate these changes using products sampled from apiaries across the established range of the beetle in eastern Australia. The starting hive products significantly affected the volatile composition of fermenting hive products, and this composition varied throughout time. We found 61.7% dissimilarity between attractive and non‐attractive fermenting hive products, and identified individual compounds that characterise each of these groups. Eleven of these individual compounds were then assessed for attractiveness, as well as testing a synthetic blend in the laboratory. In the laboratory bioassay, 82.1 ± 0.02% of beetles were trapped in blend traps. These results have strong implications for the development of an out‐of‐hive attractant trap to assist in the management of this invasive pest.