bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un desconocido incidente periodístico de Ricardo Palma
Authors: Varillas Montenegro Alberto 
Published: February 2019

Este trabajo se refiere a un incidente que no ha merecido atención alguna de los estudiosos de la literatura del siglo XIX peruano, pero que, si se analiza con la óptica de ciento cincuenta años atrás, es posible reparar en que a principios de la década de 1870 resultaba sumamente importante. En este incidente hay cuatro componentes: el primero es la participación deRicardo Palma en el semanario limeño Cascabel, de carácter netamente político destinado a atacar al Partido Civil que el 2 de agosto de 1872 había asumido el mando político en el Perú mediante el gobierno encabezado por don Manuel Pardo y Lavalle; el segundo es la reacción contra Palma desde el semanario La Sabatina, también limeño, pues los pocos que se han ocupado de él se limitan a señalar que apoyó la candidatura de Manuel Pardo a la presidencia de la república; el tercero es la vida y obra de Luis Enrique Márquez, periodista agresivo y muy aceptable versificador que ha sido marginado por nuestras historias de la literatura que solo le conceden el mérito de haber fundado La Sabatina, haber sido uno de los fundadores y el primer presidente del Círculo Literario y haber estado claramente vinculado a La Revista Social; y el cuarto es el posible origen de la animadversión de algunos periodistas contra Ricardo Palma que se inicia con los textos que se le dedica en La Sabatina y no con los discursos de González Prada de la segunda mitad de la década de 1880, como hasta ahora se repite.
Todo reconocimiento es un reto
Authors: Rodríguez Chávez Iván 
Published: February 2019

El reciente éxito de nuestra Universidad en el proceso de Licenciamiento debe servirnos para reflexionar sobre varios aspectos que se entremezclan y, por ello, podrían perderse de vista si no se depuran a tiempo. En primer lugar, nos regocija compartir este reconocimiento con el alumnado, los docentes e investigadores y, también, con el personal que administra el quehacer de nuestra comunidad universitaria. No obstante, es imprescindible poner en contexto estas palabras optimistas para explicar cómo se inició este proceso, además de resaltar la mirada crítica con la cual debemos seguir forjando una visión de autonomía y excelencia, que son las principales señales que nos distinguen.
Hacia noviembre del 2015 la Sunedu inició el control de calidad que obliga el cumplimiento de estándares en infraestructura, equipamiento, personal docente, acceso a las tecnologías de la información y comunicación, laboratorios, bibliotecas, auditorios etc., como requisito para autorizar a una institución de Educación Superior el otorgamiento de grados y títulos para el servicio profesional.
Pengaruh Pendampingan dan Penyuluhan oleh Mahasiswa KKN terhadap Perubahan Perilaku Pus Ber-KB di Alu Polewali Mandar
Authors: Firmansyah Andan 
Published: February 2019

Kabupaten Polewali Mandar merupakan Daerah Tertinggal tahun 2015-2019 berdasarkan PP no. 131 tahun 2015 dan berdasarkan data susenas 2015, Sulawesi barat berada pada kuadran 2, dimana tingkat CPR (contraceptive prevalence rate) rendah dan TFR (total fertility rate) tinggi. tujuan penelitian iniialah untuk mengetahui pengaruh pendampingan dan penyuluhan (PENYU) mahasiswa KKN terhadap Perubahan Perilaku PUS Ber-KB di Kecamatan Alu Kabupaten Polewali Mandar. Penelitian ini termasuk Quasi Eksperimental research. Penelitian ini akan dilaksanakan di Kecamatan Allu Kabupaten Polewali Mandar di dua desa yaitu desa Mombi sebagai tempat perlakuan, dan desa Pao-Pao sebagai tempat Kontrol Hasil Penelitian Menilai adanya perbedaan antara perlakuan dan control dengan uji t tidak berpasangan dengan menscoring semua hasil perhitungan variabel pengetahuan, sikap dan prilaku dengan hasil ada perbedaan yang signifikan perubahan pengetahuan. antara kelompok kasus dan kontrol melalui keterlibatan mahasiswa KKN melalui pendekatan pendampingan dan penyuluhan (penyu) pada PUS. Dengan nilai p value = 0,005. Ada perbedaan perubahan sikap dengan nilai p value = 0,001. Ada perbedaan perubahan perilaku dengan nilai p value = 0,013. Menilai adanya pengaruh antara vaiabel penelitian dengan uji Chi-Square didapatkan Adanya pengaruh antara pendampingan dan penyuyluhan (Penyu) mahasiswa KKN terhadapa perubahan pengetahuan, sikap dan prilaku PUS di kecamatan alu yaitu pengetahuan dengan p value 0,005, sikap dengan p value 0,000 dan prilaku dengan nilai p value 0,000.
Kombinasi Terapi Musik Instrumental Dan Self Hypnosis Efektif Menurunkan Tekanan Darah Klien Hipertensi
Authors: Purnomo Edi 
Published: February 2019

Hipertensi merupakan kondisi yang sering terjadi pada usia lebih dari 30 tahun, dan kejadian ini akan meningkat pada lanjut usia (usia 50 tahun). Salah satu terapi non farmakologi yang berkembang saat ini adalah hipnotherapi. Kombinasi musik instrumental dan self hypnosis merupakan pilihan alternatif untuk mencapai keadaan rileks sehingga akan mengurangi stres dan depresi pada klien hipertensi yang dapat menurunkan tekanan darahnya. Penelitian ini bertujuan untuk mengetahui efektivitas kombinasi terapi musik instrumental dan self hypnosis terhadap penurunan tekanan darah klien hipertensi di wilayah kerja Puskesmas Rangas Kabupaten Mamuju. Penelitian ini merupakan penelitian pre eksperiment dengan rancangan one group pretest-posttest. Populasi penelitian adalah pasien hipertensi yang berkunjung ke Puskesmas Rangas Kab. Mamuju. Jumlah sampel 30 orang dengan teknik penarikan sampel menggunakan purposive sampling. Hasil penelitian menunjukan perbedaan yang bermakna tekanan darah sistolik sebelum dan sesudah pemberian musik instrumental dan self hypnosis (p=0,0005) dan perbedaan yang bermakna tekanan darah diastolik sebelum dan sesudah pemberian musik instrumental dan self hypnosis (p=0,0005). Kombinasi terapi musik instrumental dan self hypnosis efektif menurunkan tekanan darah klien hipertensi. Peneliti merekomendasikan kepada para praktisi perawat dapat mengaplikasikan terapi ini untuk menurunkan tekanan darah pada klien yang mengalami hipertensi
ANALISIS UJI VALIDITAS TES BUATAN GURU BAHASA BUGIS DENGAN MENGGUNAKAN ARTIFICIAL INTELLIGENCE (AI) KELAS IX 1 SMPN 1 LABAKKANG KABUPATEN PANGKEP
Authors: Yusuf Andi muh 
Published: February 2019

Tujuan penelitian ini adalah untuk menjelaskan analisis uji validitas tes buatan guru bahasa Bugis dengan menggunakan Artificial Intelligence (AI) kelas IX 1 SMPN 1 Labakkang Kabupaten Pangkep. Jenis penelitian yang digunakan adalah penelitian kualitatif yang bersifat deskriptif. Data penelitian adalah tes-tes buatan guru sekolah yang telah diberikan kepada siswa. Sumber data penelitian ini adalah sumber tertulis berupa silabus, RPP kisi-kisi, soal (tes) yang telah dibuat guru bahasa Bugis SMPN 1 Labakkang Kabupaten Pangkep. Hasil penelitian ini Piranti Lunak Artificial Intelligence (AI) (Test-Analysis Software) berjalan sesuai yang diharapkan. Analisis uji validitas tes buatan guru menggunakan Artificial Intelligence (AI) berupa soal uraian menggunakan empat instrumen. Adapun keempat instrumen dalam menguji validitas, yaitu 1) penilaian RPP yang berada pada tataran kategori baik atau valid. 2) pengamatan uji validitas yang berada pada kategori sangat baik atau sangat valid. 3) respon siswa yang terdiri tiga kategori validitas soal (27%) yang tidak valid atau respon yang kurang baik dan respon peserta didik terhadap tes buatan guru bahasa Bugis menunjukkan valid atau respon yang baik berjumlah 24 siswa (73%). 4) analisis butir soal yang terdiri dari kategori sangat tinggi terdapat dua butir soal, yaitu butir soal ke-1 dan ke-4 (28.6 %), kategori tinggi, yaitu tiga butir soal berkategori tinggi, yaitu butir soal nomor ke-5, ke-6, dan ke-7 (42.8 %), dan kategori sedang, terdapat dua butir soal berkategori sedang, yaitu butir soal nomor 2 dan 3 (28.6). Pengujian validitas tes buatan guru ini menyatakan bahwa tes buatan guru ini berdasarkan pengkategorian validitas isi, konstruk, dan kriteria/empiris adalah valid.
Infective endocarditis in patients with pyogenic spondylodiscitis: implications for diagnosis and therapy
Authors: Behmanesh Bedjan , Gessler Florian , Schnoes Katrin , Dubinski Daniel , Won Sae-Yeon , Konczalla Jürgen , Seifert Volker , Weise Lutz , Setzer Matthias 
Published: February 2019

OBJECTIVEThe incidence of patients with pyogenic spinal infection is increasing. In addition to treatment of the spinal infection, early diagnosis of and therapy for coexisting infections, especially infective endocarditis (IE), is an important issue. The aim of this study was to evaluate the proportion of coexisting IE and the value of routine transesophageal echocardiography (TEE) in the management of these patients.METHODSThe medical history, laboratory data, radiographic findings, treatment modalities, and results of TEE of patients admitted between 2007 and 2017 were analyzed.RESULTSDuring the abovementioned period, 110 of 255 total patients underwent TEE for detection of IE. The detection rate of IE between those patients undergoing and not undergoing TEE was 33% and 3%, respectively (p < 0.0001). Thirty-six percent of patients with IE needed cardiac surgical intervention because of severe valve destruction. Chronic renal failure, heart failure, septic condition at admission, and preexisting heart condition were significantly associated with coexisting IE. The mortality rate in patients with IE was significantly higher than in patients without IE (22% vs 3%, p = 0.002).CONCLUSIONSTEE should be performed routinely in all patients with spondylodiscitis.
Anterior cervical spine surgery for the treatment of subaxial cervical spondylodiscitis: a report of 30 consecutive patients
Authors: Burkhardt Benedikt W. , Müller Simon J. , Wagner Anne-Catherine , Oertel Joachim M. 
Published: February 2019

OBJECTIVEInfection of the cervical spine is a rare disease but is associated with significant risk of neurological deterioration, morbidity, and a poor response to nonsurgical management. The ideal treatment for cervical spondylodiscitis (CSD) remains unclear.METHODSHospital records of patients who underwent acute surgical management for CSD were reviewed. Information about preoperative neurological status, surgical treatment, peri- and postoperative processes, antibiotic treatment, repeated procedure, and neurological status at follow-up examination were analyzed.RESULTSA total of 30 consecutive patients (17 male and 13 female) were included in this retrospective study. The mean age at procedures was 68.1 years (range 50–82 years), with mean of 6 coexisting comorbidities. Preoperatively neck pain was noted in 21 patients (70.0%), arm pain in 12 (40.0%), a paresis in 12 (40.0%), sensory deficit in 8 (26.7%), tetraparesis in 6 (20%), a septicemia in 4 (13.3%). Preoperative MRI scan revealed a CSD in one-level fusion in 21 patients (70.0%), in two-level fusions in 7 patients (23.3%), and in three-level fusions in 2 patients (6.7%). In 16 patients an antibiotic treatment was initiated prior to surgical treatment. Anterior cervical discectomy and fusion with cervical plating (ACDF+CP) was performed in 17 patients and anterior cervical corpectomy and fusion (ACCF) in 12 patients. Additional posterior decompression was performed in one case of ACDF+CP and additional posterior fixation in ten cases of ACCF procedures. Three patients died due to multiple organ failure (10%). Revision surgery was performed in 6 patients (20.7%) within the first 2 weeks postoperatively. All patients received antibiotic treatment for 6 weeks. At the first follow-up (mean 3 month) no recurrent infection was detected on blood workup and MRI scans. At final follow-up (mean 18 month), all patients reported improvement of neck pain, all but one patients were free of radicular pain and had no sensory deficits, and all patients showed improvement of motor strength. One patient with preoperative tetraparesis was able to ambulate.CONCLUSIONSCSD is a disease that is associated with severe neurological deterioration. Anterior cervical surgery with radical debridement and appropriate antibiotic treatment achieves complete healing. Anterior cervical plating with the use of polyetheretherketone cages has no negative effect of the healing process. Posterior fixation is recommended following ACCF procedures.
The effect of prophylactic vancomycin powder on infections following spinal surgeries: a systematic review
Authors: Dodson Vincent , Majmundar Neil , Swantic Vanessa , Assina Rachid 
Published: February 2019

OBJECTIVEThe use of vancomycin powder in spine surgery for prophylaxis against surgical site infections (SSIs) is well debated in the literature, with the majority of studies demonstrating improvement and some studies demonstrating no significant reduction in infection rate. It is well known in certain populations that vancomycin powder reduces the general rate of infection, but its effects on reducing the rate of infection due to gram-negative pathogens are not well reviewed. The goal of this paper was to review studies that investigated the efficacy of vancomycin powder as a prophylactic agent against SSI and demonstrate whether the rate of infections by gram-negative pathogens is impacted.METHODSAn electronic search of the published literature was performed using PubMed and Google Scholar in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A variety of combinations of the search terms “vancomycin powder,” “infection,” “spine,” “gram-negative,” “prophylaxis,” and “surgical site” was used. Inclusion criteria were studies that 1) described an experimental group that received intraoperative intrawound vancomycin powder; 2) included adequately controlled groups that did not receive intraoperative intrawound vancomycin powder; 3) included the number of patients in both the experimental and control groups who developed infection after their spine surgery; and 4) identified the pathogen-causing infection. Studies not directly related to this review’s investigation were excluded from the initial screen. Among the studies that met the criteria of the initial screen, additional reasons for exclusion from the systematic review included lack of a control group, unspecified size of control groups, and inconsistent use of vancomycin powder in the experimental group.RESULTSThis systematic review includes 21 studies with control groups. Vancomycin powder significantly reduced the relative risk of developing an SSI (RR 0.55, 95% CI 0.45–0.67, p < 0.0001). In addition, the use of vancomycin powder did not significantly increase the risk of infection by gram-negative pathogens (RR 1.11, 95% CI 0.66–1.86, p = 0.701).CONCLUSIONSThe results of this systematic review suggest that intrawound vancomycin powder is protective against SSI. It is less clear if this treatment increases the risk of gram-negative infection. Further studies are required to investigate whether rates of infection due to gram-negative pathogens are affected by the use of vancomycin powder.
Parasitic infections of the spine: case series and review of the literature
Authors: Majmundar Neil , Patel Purvee D. , Dodson Vincent , Tran Ashley , Goldstein Ira , Assina Rachid 
Published: February 2019

OBJECTIVEAlthough parasitic infections are endemic to parts of the developing world and are more common in areas with developing economies and poor sanitary conditions, rare cases may occur in developed regions of the world.METHODSArticles eligible for the authors’ literature review were initially searched using PubMed with the phrases “parasitic infections” and “spine.” After the authors developed a list of parasites associated with spinal cord infections from the initial search, they expanded it to include individual diagnoses, using search terms including “neurocysticercosis,” “schistosomiasis,” “echinococcosis,” and “toxoplasmosis.”RESULTSTwo recent cases of parasitic spinal infections from the authors’ institution are included.CONCLUSIONSKey findings on imaging modalities, laboratory studies suggestive of parasitic infection, and most importantly a thorough patient history are required to correctly diagnose parasitic spinal infections.
Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam
Authors: Emmert A. Scott , Vuong Shawn M. , Shula Crystal , Lindquist Diana , Yuan Weihong , Hu Yueh-Chiang , Mangano Francesco T. , Goto June 
Published: February 2019

OBJECTIVEEmergence of CRISPR/Cas9 genome editing provides a robust method for gene targeting in a variety of cell types, including fertilized rat embryos. The authors used this method to generate a transgenic rat L1cam knockout model of X-linked hydrocephalus (XLH) with human genetic etiology. The object of this study was to use diffusion tensor imaging (DTI) in studying perivascular white matter tract injury in the rat model and to characterize its pathological definition in histology.METHODSTwo guide RNAs designed to disrupt exon 4 of the L1cam gene on the X chromosome were injected into Sprague-Dawley rat embryos. Following embryo transfer into pseudopregnant females, rats were born and their DNA was sequenced for evidence of L1cam mutation. The mutant and control wild-type rats were monitored for growth and hydrocephalus phenotypes. Their macro- and microbrain structures were studied with T2-weighted MRI, DTI, immunohistochemistry, and transmission electron microscopy (TEM).RESULTSThe authors successfully obtained 2 independent L1cam knockout alleles and 1 missense mutant allele. Hemizygous male mutants from all 3 alleles developed hydrocephalus and delayed development. Significant reductions in fractional anisotropy and axial diffusivity were observed in the corpus callosum, external capsule, and internal capsule at 3 months of age. The mutant rats did not show reactive gliosis by then but exhibited hypomyelination and increased extracellular fluid in the corpus callosum.CONCLUSIONSThe CRISPR/Cas9-mediated genome editing system can be harnessed to efficiently disrupt the L1cam gene in rats for creation of a larger XLH animal model than previously available. This study provides evidence that the early pathology of the periventricular white matter tracts in hydrocephalus can be detected in DTI. Furthermore, TEM-based morphometric analysis of the corpus callosum elucidates the underlying cytopathological changes accompanying hydrocephalus-derived variations in DTI. The CRISPR/Cas9 system offers opportunities to explore novel surgical and imaging techniques on larger mammalian models.
Formation of intracranial de novo aneurysms and recurrence after neck clipping: a systematic review and meta-analysis
Authors: Spiessberger Alexander , Vogt Deborah R. , Fandino Javier , Marbacher Serge 
Published: February 2019

OBJECTIVEIncidence rates of de novo aneurysm formation and recurrence after clip ligation remain controversial. In this meta-analysis, the authors provide data on pooled annual incidence rates and the association of patient characteristics with time to formation of de novo aneurysms and time to recurrence after clipping.METHODSA search of the literature up to June 15, 2016, on PubMed and a systematic review were performed. The association of age, aneurysm rupture status, aneurysm multiplicity, and anatomical location with time to recurrence or formation of de novo aneurysm was estimated using multivariable Cox proportional-hazards models. Kaplan-Meier estimates (event-free survival curves) are shown. Pooled annualized incidence rates of recurrent and de novo aneurysms were estimated using Poisson regression. Proportions of aneurysms and average follow-up times are displayed as bubble plots with LOESS smoothers weighted for study size.RESULTSOf the 7606 articles screened, 92 were included in the study. Case reports on 101 patients with recurrent aneurysms and 132 patients with de novo aneurysms were analyzed. Long-term follow-up studies on de novo aneurysm formation included 13,723 patients with 101,378 patient-years of follow-up; studies on aneurysm recurrence included 5922 patients with 31,055 patient-years of follow-up. Mean time to recurrence was 12.9 ± 6.6 years (mean ± standard deviation), and mean time to de novo formation was 9.3 ± 6.1 years. No association with sex, aneurysm location, and initial rupture could be shown. De novo aneurysms occurred later in patients with multiplicity of aneurysms at diagnosis (HR 0.63, p = 0.03) and in patients with increasing age (HR per 10 yrs 0.88, p = 0.06). Pooled annualized incidence rates were 0.35% for de novo aneurysms and 0.13% for recurrent aneurysms.CONCLUSIONSDespite low reported annual incidence rates, the cumulative risk of 9.6%–22% for aneurysm recurrence or de novo formation 20 years after clip ligation warrants lifelong follow-up. Screening at 5, 10, and 20 years would detect 30.8% (95% CI 23.3%–37.6%), 64.2% (95% CI 55.9%–70.9%), and 95.9% (95% CI 90.9%–97.9%) of de novo aneurysms. Screening for recurrent aneurysms at 10, 15, and 20 years would detect 36.6% (95% CI 26.5%–45.4%), 65.3% (95% CI 54.7%–73.5%), and 95.1% (95% CI 85.8%–96.6%) of lesions.
Human caudate nucleus subdivisions in tinnitus modulation
Authors: Perez Philip L. , Wang Sarah S. , Heath Susan , Henderson-Sabes Jennifer , Mizuiri Danielle , Hinkley Leighton B. , Nagarajan Srikantan S. , Larson Paul S. , Cheung Steven W. 
Published: February 2019

OBJECTIVEThe object of this study was to define caudate nucleus locations responsive to intraoperative direct electrical stimulation for tinnitus loudness modulation and relate those locations to functional connectivity maps between caudate nucleus subdivisions and auditory cortex.METHODSSix awake study participants who underwent bilateral deep brain stimulation (DBS) electrode placement in the caudate nucleus as part of a phase I clinical trial were analyzed for tinnitus modulation in response to acute stimulation at 20 locations. Resting-state 3-T functional MRI (fMRI) was used to compare connectivity strength between centroids of tinnitus loudness-reducing or loudness-nonreducing caudate locations and the auditory cortex in the 6 DBS phase I trial participants and 14 other neuroimaging participants with a Tinnitus Functional Index > 50.RESULTSAcute tinnitus loudness reduction was observed at 5 caudate locations, 4 positioned at the body and 1 at the head of the caudate nucleus in normalized Montreal Neurological Institute space. The remaining 15 electrical stimulation interrogations of the caudate head failed to reduce tinnitus loudness. Compared to the caudate head, the body subdivision had stronger functional connectivity to the auditory cortex on fMRI (p < 0.05).CONCLUSIONSAcute tinnitus loudness reduction was more readily achieved by electrical stimulation of the caudate nucleus body. Compared to the caudate head, the caudate body has stronger functional connectivity to the auditory cortex. These first-in-human findings provide insight into the functional anatomy of caudate nucleus subdivisions and may inform future target selection in a basal ganglia–centric neuromodulation approach to treat medically refractory tinnitus.Clinical trial registration no.: NCT01988688 (clinicaltrials.gov)