bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic Anterior Cruciate Ligament Reconstruction: A Meta-Analysis Comparing Semitendinosus Alone and Semitendinosus with Gracilis Tendon Autografts
Authors: Chin Brian Zhaojie , Wee Ian Jun Yan , Syn Nicholas Li-Xun , Krishna Lingaraj 
Published: September 2018

AbstractThe objective of this study was to provide a comprehensive systematic review and meta-analysis to compare patient-reported outcomes and functional knee parameters of anterior cruciate ligament (ACL) reconstruction surgery with semitendinosus (ST) and ST-gracilis (G) grafts. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines. All studies in PubMed and Embase that reported functional knee parameters and patient-reported outcomes after ACL reconstruction with ST and ST-G grafts independently were included in the review. Selected end points for random effects, pairwise meta-analysis included side-to-side deficit (%) in isokinetic peak torque, peak torque ratio (%), side-to-side difference (mm) in anterior laxity, and patient-reported outcome scores at minimum 2-year follow-up. A total of 15 primary references comprising 1,109 participants were identified. The ST group had decreased side-to-side deficit in isokinetic peak torque when compared with the ST-G group for flexion at 60 degrees/s (p = 0.02) and 180 degrees/s (p = 0.01) at 2-year follow-up. There were no significant differences in side-to-side difference in anterior laxity (p = 0.81), hamstring/quadriceps peak torque ratios at 60 degrees/s (p = 0.83) and 180 degrees/s (p = 0.36), and patient-reported outcomes in the International Knee Documentation Committee score (p = 0.06) and Lysholm score (p = 0.67). The addition of the gracilis tendon to the hamstring autograft in ACL reconstruction results in increased side-to-side deficits in isokinetic peak flexion torque. However, patient-reported outcome scores and knee laxity measurements are comparable with those of ST grafts.
Homeopathy Seen as Personalised Nanomedicine
Authors: Rajendran E. S. 
Published: September 2018

AbstractAmong all the discoveries of Hahnemann, potentisation was the most important, though controversial. The curative effect of individualised homeopathic potencies is empirical but inexplicable by the conventional principles of science. This paradox is a highly contentious topic of debate between rationalists and homeopaths. Recent discoveries relating to the nano-particulate nature of homeopathic ultra-high potencies and their potential effect on individual gene expression give new insights into this complex issue. It is concluded that homeopathy may be viewed as ‘personalised nanomedicine’.
The European Psychiatric Association: Mission, Structure and Perspectives
Authors: Gaebel W. , Falkai P. 
Published: September 2018

SummaryThe European Psychiatric Association (EPA) is an association of individual members and national psychiatric societies with the aim to improve mental health care in Europe. In the last years, EPA has developed from an association of individuals into a representative stakeholder for European psychiatry and European psychiatrists. EPA is well connected with other stakeholders in the field of European psychiatry. To make good use of the potential of experts and experiences in the EPA in order to improve mental health care in Europe will be a challenge for the next years.
The future role of psychiatry in Europe – The WHO European Mental Health Action Plan
Authors: Muijen M. 
Published: September 2018

SummaryEuropean Member States of the WHO requested the preparation of a European Mental Health Action Plan, to be implemented by 2020, and complementary to the Global Comprehensive Mental Health Action Plan. This Plan covers activities to improve population well-being and reduce the burden of mental disorders; respect the rights of people with mental disorders; and strengthen or establish access to respectful, safe and effective services. It builds on the Helsinki Declaration of 2005. The plan sets a challenging agenda for governments, especially at a time when needs are high but public spending budgets restricted. It also proposes actions relevant to the roles and responsibilities of mental health services, psychiatrists and other staff.
Antisoziale Persönlichkeitsstörung
Authors: Mancke F. , Herpertz S. C. 
Published: September 2018

ZusammenfassungDie Verknüpfung zwischen Persönlichkeitseigenschaften und antisozialen Verhaltensweisen kann anhand der Antisozialen Persönlichkeitsstörung (ASP) nach DSM-5, der Dissozialen Persönlichkeitsstörung nach ICD-10 oder dem Konstrukt der „Psychopathy“ nach Hare erfasst werden. Unterschiede zwischen diesen Konzepten finden sich vor allem in der Gewichtung affektiver und interpersoneller Persönlichkeitszüge. Zur Ätiopathogenese tragen genetische, weitere neurobiologische und multiple psychosoziale Faktoren (Erziehungsstil, Misshandlungen, sozioökonomischer Status etc.) sowie deren Wechselwirkungen bei. Befunde aus der Bildgebung weisen auf eine besondere Bedeutung präfrontaler und amygdalärer Strukturen hin. Testosteron und Vasopressin zeigen einen positiven Zusammenhang mit antisozialen Verhaltensweisen, wohingegen Serotonin, Kortisol und Oxytocin eine negative Assoziation aufweisen. Neurokognitive Defizite finden sich v.a. bei psychopathischen Individuen und beinhalten eine Einschränkung der emotionalen Empathie und des emotionalen Lernens. Psychotherapeutische Interventionen sollten hochstrukturiert und eher behavioral ausgerichtet sein. Psychopharmakologische Interventionen erfolgen „off-label“ und symptomorientiert
Historische Entwicklung, Diagnostik und Klassifikation der Somatoformen Störungen – Vergleich von ICD-10, DSM-IV-TR und DSM-5
Authors: Zaudig M. 
Published: September 2018

ZusammenfassungDer vorliegende Artikel beschreibt die aktuellen diagnostischen Entwicklungen im Bereich der Somatoformen Störung unter Zugrundelegung der aktuellen S3-Leitlinien für „Nichtspezifische funktionelle und somatoforme Körperbeschwerden“ und der historischen Entwicklung der Somatoformen Störungen (einschließlich der Hypochondrie). Neben einem Vergleich von ICD-10 mit DSM-IV-TR und DSM-5 werden die neuen Kriterien für Somatic Symptom Disorder und Illness Anxiety Disorder (vormals Hypochondrie) nach DSM-5 vorgestellt und diskutiert.
Zwangsstörungen: Prävention und Versorgungssituation
Authors: Hauer M. , Voderholzer U. 
Published: September 2018

ZusammenfassungNach dem erst kürzlich durchgeführten Gesundheitssurvey des Robert Koch-Instituts sind Zwangsstörungen die vierthäufigste psychische Störung in Deutschland. Die Versorgungssituation ist gekennzeichnet durch lange Behandlungslatenzen und insgesamt eher niedrige Behandlungsraten sowie einen Mangel an spezialisierten Therapeuten. Die Datenlage zur Prävention ist insgesamt noch sehr gering. Präventionsstudien könnten auf frühere Erkennung und Behandlung, auf Awareness bezüglich spezifischer Behandlungsmöglichkeiten, sowie auf Rückfallprophylaxe nach erfolgreicher Therapie zielen.
Aggressivität und Schuldfähigkeit*
Authors: Maatz K. R. 
Published: September 2018

ZusammenfassungDie beängstigende Zahl massivst gewalttätiger Übergriffe durch zumeist jugendliche oder junge (meist männliche) Täter im öffentlichen Raum auf Zufallsopfer, Übergriffe, die regelmäßig ohne jeden äußeren Anlass „vom Zaun gebrochen“ werden und ohne jede Hemmung ablaufen, zwingt zu einer öffentlichen Diskussion über Hintergründe und geeignete Präventionsmaßnahmen. In diesem Zusammenhang behandelt der vorliegende Beitrag die für die strafrechtliche Ahndung solcher Gewalttaten wesentlichen Aspekte. Gewaltausübung als „Ausfluss“ von sog. genuiner Aggressivität wirft vor allem die forensisch-psychiatrisch bedeutsame Frage nach der – vom Verfasser im Regelfall bejahten – (strafrechtlichen) Verantwortlichkeit der Täter auf, eine Frage, deren Beantwortung auch über die angemessene Sanktion (mit)entscheidet.
Breast Cancers With Magee Equation Score of Less Than 18, or 18-25 and Mitosis Score of 1, Do Not Require Oncotype DX Testing
Authors: Bhargava Rohit , Clark Beth Z , Dabbs David J 
Published: September 2018

AbstractObjectivesTo investigate use of Magee equations (MEs) to determine which breast cancer cases can be excluded from Oncotype DX testing.MethodsA prospective value study was carried out using data from pathology reports.ResultsIf all three MEs scores were less than 18 or 31 or higher, the cases were labeled do not send for testing. If any or all scores were 18 to 25, cases were labeled do not send if mitosis score was 1. Of the total 205 cases, 146 (71%) were labeled do not send; of these, the correct call was made in 143 (98%) cases. Two of the three discordant cases had associated nontumor factors, likely resulting in higher scores.ConclusionsCases with ME scores less than 18, or 18 to 25 and mitosis score 1, do not require Oncotype DX testing, an estimated saving of US$280,000 per 100 clinical requests.
Asymptotic Stability for Some Non positive Perturbations of the Camassa–Holm Peakon with Application to the Antipeakon–peakon Profile
Authors: Molinet Luc 
Published: September 2018

AbstractWe continue our investigation on the asymptotic stability of the peakon. In a 1st step we extend our asymptotic stability result [30] in the class of functions whose negative part of the momentum density is supported in $]-\infty ,x_0] $ and the positive part in $[x_0,+\infty [$ for some $ x_0\in{\mathbb{R}}$. In a 2nd step this enables us to prove the asymptotic stability of well-ordered train of antipeakons–peakons and, in particular, of the antipeakon–peakon profile. Finally, in the appendix we prove that in the case of a nonnegative momentum density the energy at the left of any given point decays to zero as time goes to $+\infty $. This leads to an improvement of the asymptotic stability result stated in [30].
SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma
Authors: Cai Qianqian , Liu Yuanyuan , Zhu Ping , Kang Chunlang , Xu Heyang , Qi Bing , Wang Rong , Dong Yiwei , Wu Xing Zhong 
Published: September 2018

Abstract
Paired amphipathic helix protein (SIN3B) is a transcription corepressor for many genes. Here we show a different regulation mechanism of integrin αV gene expression by SIN3B in human hepatocellular carcinoma (HCC). We first observed a close relationship between Integrin αV and SIN3B expressions in HCC patients and tumor cell lines with different metastatic potentials. Overexpression of SIN3B significantly accelerated the cell migration rate of SMMC-7721, but failed when integrin αV expression was silenced. Interestingly, SIN3B stimulated integrin αV subunit promoter activity only in the presence of sulfatide. Importantly, SIN3B was identified in the complex with sulfatide by mass spectrometry. Fat blot assay indicated that SIN3B specifically interacted with sulfatide. Molecular modeling suggested that sulfatide induced the conformational change of SIN3B from compacted α-helices to a relaxed β-sheet in PAH2 domain. The data of immunoprecipitation and ChIP assay indicated that altered SIN3B lost the binding affinity with MAD1 and HDAC2, which reduced the recruitment of HDAC2 on integrin αV gene promoter and prevented the deacetylation of the histone 3. In conclusion, this study demonstrated that SIN3B promoted the transcriptional activation of the integrin αV subunit gene promoter by reducing interaction with HDAC2.
The turbulent pressure support in galaxy clusters revisited
Authors: Vazza F , Angelinelli M , Jones T W , Eckert D , Brüggen M , Brunetti G , Gheller C 
Published: September 2018

ABSTRACT
Due to their late formation in cosmic history, clusters of galaxies are not fully in hydrostatic equilibrium and the gravitational pull of their mass at a given radius is expected not to be entirely balanced by the thermal gas pressure. Turbulence may supply additional pressure, and recent (X-ray and SZ) hydrostatic mass reconstructions claim a pressure support of ${\sim } 5\!-\!15{{\ \rm per\ cent}}$ of the total pressure at R200. In this work we show that, after carefully disentangling bulk from small-scale turbulent motions in high-resolution simulations of galaxy clusters, we can constrain which fraction of the gas kinetic energy effectively provides pressure support in the cluster’s gravitational potential. While the ubiquitous presence of radial inflows in the cluster can lead to significant bias in the estimate of the non-thermal pressure support, we report that only a part of this energy effectively acts as a source of pressure, providing a support of the order of ${\sim } 10{{\ \rm per\ cent}}$ of the total pressure at R200.
Clinical and Radiological Follow-up of Intraneural Perineuriomas
Authors: Wilson Thomas J , Amrami Kimberly K , Howe B Matthew , Spinner Robert J 
Published: September 2018

ABSTRACT

BACKGROUND
Management of intraneural perineuriomas remains controversial, largely due to the lack of knowledge regarding the natural history of these lesions.

OBJECTIVE
To describe the typical radiological growth pattern of intraneural perineuriomas and to determine how the pattern of growth relates to clinical progression.

METHODS
We performed a retrospective review of the magnetic resonance imaging (MRI) studies and serial clinical examinations of a cohort of patients with biopsy-proven intraneural perineuriomas who had 2 MRI studies at least 2 yr apart. The outcome of interest was radiological growth in length or width of the intraneural perineurioma. Radiological growth was tested for association with clinical progression.

RESULTS
Twenty patients were included in the study. By width, the lesions were on average larger on repeat imaging (P = .009). By absolute length, the lesions were on average longer on repeat imaging (P = .02). By lesion:landmark ratio, there was no difference in length of the lesions between sequential images (P = .09), with 10 (50%) lesions being shorter and 7 (35%) showing no change. No lesions grew to involve a new nerve or division of a nerve on sequential imaging. None of the variables tested were associated with clinical progression.

CONCLUSION
We found that intraneural perineuriomas only rarely grow in length, do not grow to involve new nerves or nerve divisions, and growth does not correlate with clinical progression. These findings have significant ramifications for management of these tumors.
Working Memory Impairment Across Psychotic disorders
Authors: Gold James M , Barch Deanna M , Feuerstahler Leah M , Carter Cameron S , MacDonald Angus W , Ragland J Daniel , Silverstein Steven M , Strauss Milton E , Luck Steven J 
Published: September 2018

Abstract

Background
Working memory (WM) has been a central focus of cognitive neuroscience research because WM is a resource that is involved in many different cognitive operations. The goal of this study was to evaluate the clinical utility of WM paradigms developed in the basic cognitive neuroscience literature, including methods designed to estimate storage capacity without contamination by lapses of attention.

Methods
A total of 61 people with schizophrenia, 49 with schizoaffective disorder, 47 with bipolar disorder with psychosis, and 59 healthy volunteers were recruited. Participants received multiple WM tasks, including two versions each of a multiple Change Detection paradigm, a visual Change Localization paradigm, and a Running Span task.

Results
Healthy volunteers performed better than the combined patient group on the visual Change Localization and running span measures. The multiple Change Detection tasks provided mixed evidence about WM capacity reduction in the patient groups, but a mathematical model of performance suggested that the patient groups differed from controls in their rate of attention lapsing. The 3 patient groups performed similarly on the WM tasks. Capacity estimates from the Change Detection and Localization tasks showed significant correlations with functional capacity and functional outcome.

Conclusions
The patient groups generally performed in a similarly impaired fashion across tasks, suggesting that WM impairment and attention lapsing are general features of psychotic disorders. Capacity estimates from the Change Localization and Detection tasks were related to functional capacity and outcome, suggesting that these methods may be useful in a clinical context.
COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome
Authors: Strien Joeri Van , Guerrero-Castillo Sergio , Chatzispyrou Iliana A. , Houtkooper Riekelt H. , Brandt Ulrich , Huynen Martijn A. 
Published: September 2018

ABSTRACTMotivationComplexome profiling combines native gel electrophoresis with mass spectrometry to obtain the inventory, composition and abundance of multiprotein assemblies in an organelle. Applying complexome profiling to determine the effect of a mutation on protein complexes requires separating technical and biological variations from the variations caused by that mutation.ResultsWe have developed the COmplexome Profiling ALignment (COPAL) tool that aligns multiple complexome profiles with each other. It includes the abundance profiles of all proteins on two gels, using a multidimensional implementation of the dynamic time warping algorithm to align the gels. Subsequent progressive alignment allows us to align multiple profiles with each other. We tested COPAL on complexome profiles from control mitochondria and from Barth syndrome (BTHS) mitochondria, which have a mutation in tafazzin gene that is involved in remodelling the inner mitochondrial membrane phospholipid cardiolipin. By comparing the variation between BTHS mitochondria and controls with the variation among either, we assessed the effects of BTHS on the abundance profiles of individual proteins. Combining those profiles with gene set enrichment analysis allows detecting significantly affected protein complexes. Most of the significantly affected protein complexes are located in the inner mitochondrial membrane (MICOS, prohibitins), or are attached to it (the large ribosomal subunit).Availability and implementationCOPAL is written in Python and is available from gttp://github.com/cmbi/copal.Contacthuynen@cmbi.ru.nl
Brain correlates of action word memory
Authors: Shebani Zubaida , Carota Francesca , Hauk Olaf , Rowe James B. , Barsalou Lawrence W. , Tomasello Rosario , Pulvermüller Friedemann 
Published: September 2018

AbstractWhen understanding language semantically related to actions, the motor cortex is active and may be sensitive to semantic information, for example about the body-part-relationship of displayed action-related words. Conversely, movements of the hands or feet can impair memory performance for arm- and leg-related action words respectively, suggesting that the role of motor systems extends to verbal working memory. Here, we studied brain correlates of verbal memory load for action-related words using event-related fMRI during the encoding and memory maintenance of word lists. Seventeen participants saw either four identical or four different words from the same category, semantically related to actions typically performed either with the arms or with the legs. After a variable delay of 4-14 seconds, they performed a nonmatching-to-sample task. Hemodynamic activity related to the information load of words at presentation was most prominent in left temporo-occipital and bilateral posterior-parietal areas. In contrast, larger demand on verbal memory maintenance produced greater activation in left premotor and supplementary motor cortex, along with posterior-parietal areas, indicating that verbal memory circuits for action-related words include the cortical action system. Somatotopic memory load effects of arm- and leg-related words were not present at the typical precentral loci where earlier studies had found such word-category differences in reading tasks, although traces of somatotopic semantic mappings were observed at more anterior cortical regions. These results support a neurocomputational model of distributed action-perception circuits (APCs), according to which language understanding is manifest as full ignition of APCs, whereas working memory is realized as reverberant activity gradually receding to multimodal prefrontal and lateral temporal areas.
Ribosome profiling analysis of eEF3-depletedSaccharomyces cerevisiae
Authors: Kasari Villu , Margus Tõnu , Atkinson Gemma C. , Johansson Marcus J.O. , Hauryliuk Vasili 
Published: September 2018

AbstractIn addition to the standard set of translation factors common in eukaryotic organisms, protein synthesis in the yeastSaccharomyces cerevisiaerequires an ABCF ATPase factor eEF3, eukaryotic Elongation Factor 3. eEF3 is an E-site binder that was originally identified as an essential factor involved in the elongation stage of protein synthesis. Recent biochemical experiments suggest an additional function of eEF3 in ribosome recycling. We have characterised the global effects of eEF3 depletion on translation using ribosome profiling. Depletion of eEF3 results in decreased ribosome density at the stop codon, indicating that ribosome recycling does not become rate limiting when eEF3 levels are low. Consistent with a defect in translation elongation, eEF3 depletion causes a moderate redistribution of ribosomes towards the 5’ part of the open reading frames. We observed no E-site codon-or amino acid-specific ribosome stalling upon eEF3 depletion, supporting its role as a general elongation factor. Surprisingly, depletion of eEF3 leads to a relative decrease in P-site proline stalling, which we hypothesise is a secondary effect of generally decreased translation and/or decreased competition for the E-site with eIF5A.
Protein Family Classification using Deep Learning
Authors: Naveenkumar K S , Mohammed Harun Babu R , Vinayakumar R , Soman KP 
Published: September 2018

AbstractProtein classification is responsible for the biological sequence, we came up with an idea which deals with the classification of proteomics using deep learning algorithm. This algorithm focuses mainly to classify sequences of protein-vector which is used for the representation of proteomics. Selection of the type protein representation is challenging based on which output in terms of accuracy is depended on, The protein representation used here is n-gram i.e. 3-gram and Keras embedding used for biological sequences like protein. In this paper we are working on the Protein classification to show the strength and representation of biological sequence of the proteins.