bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Premorbid Psychiatric History and Current Mood Ratings on Self-Reported Concussion Symptom Severity
Authors: Presley C , Tarkenton T , Meredith-Duliba T , Sabo T , Miller S , Bell K , Batjer H , Cullum C M 
Published: July 2019

Abstract

Purpose
Psychiatric history is known to be relevant to concussion outcomes, although less is known about the role of such factors or current mood ratings in adolescents. The aim of this study was to assess the role of premorbid psychiatric history (PPH) and current mood ratings (CMR) on overall sports-related concussion (SRC) symptomology and cognitive outcomes in adolescent and young adult athletes.

Methods
Participants age 12–25 years (M=14.8) diagnosed with SRC (n=560) were evaluated within 14 days of injury as part of the North Texas Concussion Registry (ConTex) using the Patient Health Questionnaire-8 Items (PHQ-8), General Anxiety Disorder-7 Item Scale (GAD-7), and ImPACT. Subjects were dichotomized into those with (PPH+) and without (PPH-) pre-existing reported psychiatric diagnoses, and CMR groups were determined by normal vs. elevated scores on the GAD-7 and PHQ-8. T-tests were used to compare groups.

Results
Significant differences in total symptom severity scores were found between both PPH (p=.01) and CMR (p<.001) groupings. PPH+ (n=27) reported significantly higher symptom scores (M=31.6) than PPH- subjects (n=316, M=20.9). Additionally, those reporting elevated CMR endorsed 2.3x higher symptom severity scores (n=48, M=42.1 vs. n=276, M=18.2). Among ImPACT cognitive scores, only Visual Memory differed between CMR groups (p=.047).

Conclusion
Findings suggest that PPH and elevated CMR are associated with greater self-reported symptom severity in adolescent SRC, but have little relationship to cognitive outcomes as assessed by ImPACT. Further research is needed to understand the interaction between PPH, CMR, and SRC recovery across the age spectrum.
Test-Retest Reliability of ImPACT Across a Two-Year Interval in Collegiate Athletes
Authors: Burley C , Datoc A , Bennett R , Lashley L 
Published: July 2019

Abstract

Purpose
To examine the two-year test-retest reliability of Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) in a sample of collegiate athletes.

Methods
A total of 163 college athletes (63.8% female) completed two pre-season baseline assessments two years apart as mandated by their athletic programs. Participants completed the first baseline prior to their first year of competition (M age=18.38, M edu=12.13). Individuals with baselines flagged as invalid by ImPACT were excluded. No diagnosed concussions occurred between baseline assessments.

Results
Pearson r correlations for ImPACT composite scores between assessments ranged from .32 to .70. Paired samples t-tests indicated significant differences between verbal memory (t(162)=-4.61, p<.001, MD=-3.6) and visual-motor speed (t(162)=-4.10, p<.001, MD=-1.5) at time 1 and time 2. Intraclass correlation coefficients (ICCs) with a “two-way mixed” model and “consistency” type indicated higher reliability for all composite scores. Visual-motor speed (mean ICC=.83; .76–.87 95% confidence interval [CI]) was the most reliable composite score, followed by visual memory (.66; 95% CI .53-.75), impulse control (.62; 95% CI .48–.72), verbal memory (.58; 95% CI .43–.69), and reaction time (.49; 95% CI .30-.62). The total symptom score showed moderate reliability (.63; 95% CI .50–.73).

Conclusion
Overall, ImPACT composite and total symptom scores appear to maintain relative long-term stability in a collegiate sample across a two-year period. ImPACT composite scores showed moderate to good reliability, and total symptom scores showed moderate reliability. Results of this study corroborate previous research indicating moderately stable ImPACT scores across a 2-year test-retest period in collegiate athletes (Schatz, 2010).
The Test-Retest Reliability of a Clinically-Relevant Dual-Task Assessment in Healthy College Students
Authors: Erdman N K , Jimenez J , Buckley T A , Howell D R , Hart J M , Resch J E 
Published: July 2019

Abstract

Purpose
The dual-task (DT) paradigm consists of concurrent administration of motor and cognitive tasks which may demonstrate improved measurement properties of the included tasks as compared to independent administration. Our study examined the test-retest reliability of a clinically-relevant DT assessment.

Methods
Our prospective cohort study included 60 (53.3% female) healthy, recreationally active college students (Age=20.5–1.34 years; Height=171.7–9.33 cm). Participants completed the Standardized Assessment of Concussion (SAC) and timed tandem gait (TTG) test concurrently for the DT assessment at two time points separated by a two-week test-retest interval. The SAC composite score (45 points) was calculated by summing the domain scores of immediate memory (30 points) which consisted of a 10-word list, concentration (5 points), and delayed recall (10 points). The TTG composite score was calculated by summing the mean time to complete the TTG during each SAC task (3 trials for immediate memory, up to 5 trials for the digits-backwards task, and one trial for the months in reverse order and delayed recall tasks). Mixed-model intraclass correlation coefficients (ICC[3,1]) with 95% confidence intervals were calculated to evaluate test-retest reliability between time points for the SAC and TTG composite scores.

Results
Mean SAC (39.4–3.80 vs. 39.6–3.49 points) and TTG (52.1–9.44 vs. 48.2–8.33 sec) composite scores were observed at time points 1 and 2, respectively. Moderate (ICC[3,1]=0.56 [0.26, 0.74]) and good (ICC[3,1]=0.88 [0.80, 0.93]) test-retest reliability were observed for the SAC and TTG composite scores, respectively.

Conclusion
Test-retest reliability for our DT assessment aligns with previously established values for independent administration of the SAC and TTG.
Post-concussion Driving Management Practices Among Certified Athletic Trainers
Authors: Schmidt J D , Lynall R C , Lempke L B , Devos H 
Published: July 2019

Abstract

Purpose
To describe post-concussion driving management practices and opinions among athletic trainers (ATs) and to compare practices across highest earned degree, setting, and years certified.

Methods
A survey weblink was emailed to a convenience sample of 8,723 ATs (10.8% response rate [945/8723]; years certified=14.5±10.7; years worked clinically=12.4±9.4). The validated survey captured AT driving management practices and opinions (agreement on a seven-point Likert scale). We compared the percentage of patients instructed to refrain from driving across highest earned degree, setting, and years certified using Kruskal-Wallis tests (alpha=0.05).

Results
When asked whether they recommended concussed patients refrain from driving, 58.5% of ATs responded “sometimes” (n=553/945), 37.9% responded “always” (n=358/945), and 3.6% responded “never” (n=34/945). ATs most commonly: recommended patients refrain from driving until symptom resolution (44.7%, n=399/892); utilized their clinical exam to determine readiness to return-to-drive (64.9%, n=579/892); and provided instructions verbally (94.2%, n=840/892). ATs agreed that “patients that are impaired by a concussion are a danger on the road”, but only somewhat agreed that “patients with suspected concussion should not drive a motor vehicle until cleared to do so by a medical professional” (median=5). High school (60.5±37.6%) and clinic-based ATs (66.5±31.2%) trended towards higher percentages of patients instructed to refrain from driving relative to college (52.3±38.2%; H(2)=5.92,p=0.052). No other differences observed.

Conclusion
ATs recommend driving restrictions to some, but not all, concussed patients. ATs recognize post-concussion driving dangers, but do not strongly endorse refraining from driving after concussion. High school and clinic-based ATs may manage more adolescent novice drivers and, therefore, act more conservatively.
Examining Optimism Bias in Predicting Concussion Reporting Intentions and Behaviors Among Student-Athletes
Authors: Le R K , Weber M L , Gay J L , Welch C E , Schmidt J D 
Published: July 2019

Abstract

Purpose
The purpose of this study was to determine whether optimism bias is associated with concussion reporting intentions. We hypothesized that student-athletes who are optimistic about whether they will suffer a concussion have lower concussion reporting intentions, relative to those that are neutral or pessimistic.

Methods
Student-athletes from three Georgia universities (Divisions I, II, III) completed an optimism bias survey (n=333, age=19.86–1.52 years, males=217, females=116, response rate=28.2%). The optimism bias survey assesses the student-athletes’ beliefs regarding how likely an event is to occur (e.g. “sustained prolong recovery following concussion”). Participants were grouped into three categories: pessimists (above median), neutral (at median), and optimists (below median). Student-athletes rated their agreement with statements regarding symptom and concussion reporting intentions. Higher average score across items is indicative of greater intentions to report. A priori α was set to p=.05.

Results
Optimism bias category significantly predicted symptom reporting intentions (F(2, 329)=4.5, p=.012, r2=.026) and a trend for concussion reporting intentions (F(2, 329)=3.0, p=.052, r2=.018). Being categorized as neutral and optimists, as compared to pessimists, would be expected to decrease symptom reporting intentions by 0.48 (β=-.178, p=.013) and 0.50 (β=-.203, p=.005) respectively, and concussion reporting intention by 0.34 (β=-.169, p=.018) and 0.26 (β=-.140, p=.05).

Conclusion
Optimism bias has a small, but significant influence on concussion reporting intentions, with pessimists having better reporting intentions compared to those that are neutral or optimistic regarding their risk for suffering a concussion. Therefore, incorporating optimism bias could further educate healthcare professionals on student-athletes' risk when compared to others.
Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†
Authors: Gegenfurtner Katrin , Fröhlich Thomas , Kösters Miwako , Mermillod Pascal , Locatelli Yann , Fritz Sébastien , Salvetti P , Forde Niamh , Lonergan Patrick , Wolf Eckhard , Arnold Georg J 
Published: July 2019

Abstract
The oviduct plays a crucial role in fertilization and early embryo development providing the microenvironment for oocyte, spermatozoa, and early embryo. Since dairy cow fertility declined steadily over the last decades, reasons for early embryonic loss have gained increasing interest. Analyzing two animal models, this study aimed to investigate the impact of genetic predisposition for fertility and of metabolic stress on the protein composition of oviduct fluid. A metabolic model comprised maiden Holstein heifers and postpartum lactating (Lact) and non-lactating (Dry) cows, while a genetic model consisted of heifers from the Montbéliarde breed and Holstein heifers with low- and high-fertility index. In a holistic proteomic analysis of oviduct fluid from all groups using nano-liquid chromatography tandem-mass spectrometry analysis and label-free quantification, we were able to identify 1976 proteins, among which 143 showed abundance alterations in the pairwise comparisons within both models. Most differentially abundant proteins were revealed between low fertility Holstein and Montbéliarde (52) in the genetic model and between lactating and maiden Holstein (19) in the metabolic model, demonstrating a substantial effect of genetic predisposition for fertility and metabolic stress on the oviduct fluid proteome. Functional classification of affected proteins revealed actin binding, translation, and immune system processes as prominent gene ontology (GO) clusters. Notably, Actin-related protein 2/3 complex subunit 1B and the three immune system-related proteins SERPIND1 protein, immunoglobulin kappa locus protein, and Alpha-1-acid glycoprotein were affected in both models, suggesting that abundance changes of immune-related proteins in oviduct fluid play an important role for early embryonic loss.
Cyclins regulating oocyte meiotic cell cycle progression†
Authors: Li Jian , Qian Wei-Ping , Sun Qing-Yuan 
Published: July 2019

Abstract
Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells， the oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to become a haploid gamete. Notably, oocyte meiotic progression includes two rounds of unique meiotic arrest and resumption. The first arrest occurs at the G2 (germinal vesicle) stage and meiosis resumption is stimulated by a gonadotropin surge; the second arrest takes place at the metaphase II stage, the stage from which it is released when fertilization takes place. The maturation-promoting factor, which consists of cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1), is responsible for regulating meiotic resumption and progression, while CDK1 is the unique CDK that acts as the catalytic subunit of maturation-promoting factor. Recent studies showed that except for cyclin B1, multiple cyclins interact with CDK1 to form complexes, which are involved in the regulation of meiotic progression at different stages. Here, we review and discuss the control of oocyte meiotic progression by cyclins A1, A2, B1, B2, B3, and O.
Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination
Authors: Efthymiou Stephanie , Salpietro Vincenzo , Malintan Nancy , Poncelet Mallory , Kriouile Yamna , Fortuna Sara , De Zorzi Rita , Payne Katelyn , Henderson Lindsay B , Cortese Andrea , Maddirevula Sateesh , Alhashmi Nadia , Wiethoff Sarah , Ryten Mina , Botia Juan A , Provitera Vincenzo , Schuelke Markus , Vandrovcova Jana ,   SYNAPS Study Group, Groppa Stanislav , Karashova Blagovesta Marinova , Nachbauer Wolfgang , Boesch Sylvia , Arning Larissa , Timmann Dagmar , Cormand Bru , Pérez-Dueñas Belen , Goraya Jatinder S , Sultan Tipu , Mine Jun , Avdjieva Daniela , Kathom Hadil , Tincheva Radka , Banu Selina , Pineda-Marfa Mercedes , Veggiotti Pierangelo , Ferrari Michel D , van den Maagdenberg Arn M J M , Verrotti Alberto , Marseglia Giangluigi , Savasta Salvatore , García-Silva Mayte , Ruiz Alfons Macaya , Garavaglia Barbara , Borgione Eugenia , Portaro Simona , Sanchez Benigno Monteagudo , Boles Richard , Papacostas Savvas , Vikelis Michail , Rothman James , Kullmann Dimitri , Papanicolaou Eleni Zamba , Dardiotis Efthymios , Maqbool Shazia , Ibrahim Shahnaz , Kirmani Salman , Rana Nuzhat Noureen , Atawneh Osama , Lim Shen-Yang , Shaikh Farooq , Koutsis George , Breza Marianthi , Mangano Salvatore , Scuderi Carmela , Borgione Eugenia , Morello Giovanna , Stojkovic Tanya , Zollo Massimo , Heimer Gali , Dauvilliers Yves A , Minetti Carlo , Al-Khawaja Issam , Al-Mutairi Fuad , Hamed Sherifa , Pipis Menelaos , Bettencourt Conceicao , Rinaldi Simon , Walsh Laurence , Torti Erin , Iodice Valeria , Najafi Maryam , Karimiani Ehsan Ghayoor , Maroofian Reza , Siquier-Pernet Karine , Boddaert Nathalie , De Lonlay Pascale , Cantagrel Vincent , Aguennouz Mhammed , El Khorassani Mohamed , Schmidts Miriam , Alkuraya Fowzan S , Edvardson Simon , Nolano Maria , Devaux Jérôme , Houlden Henry 
Published: July 2019

See Karakaya and Wirth (doi:10.1093/brain/awz273) for a scientific commentary on this article.Neurofascin (NFASC) isoforms are immunoglobulin cell adhesion molecules involved in node of Ranvier assembly. Efthymiou et al. identify biallelic NFASC variants in ten unrelated patients with a neurodevelopmental disorder characterized by variable degrees of central and peripheral involvement. Abnormal expression of Nfasc155 is accompanied by severe loss of myelinated fibres.
Evaluating Household Transmission of Invasive Group A Streptococcus Disease in the United States Using Population-based Surveillance Data, 2013–2016
Authors: Adebanjo Tolulope , Apostol Mirasol , Alden Nisha , Petit Susan , Tunali Amy , Torres Salina , Hollick Rosemary , Bell Austin , Muse Alison , Poissant Tasha , Schaffner William , Van Beneden Chris A 
Published: July 2019

Abstract
Using population-based surveillance data, we quantified the secondary invasive group A Streptococcus disease risk among household contacts. The disease risk in the 30 days postexposure to an index-case patient was highest among individuals aged ≥65 years, versus the annual background incidence of all ages.
Anthropogenic noise does not surpass land cover in explaining habitat selection of Greater Prairie-Chicken (Tympanuchus cupido)
Authors: Raynor Edward J , Harrison Jocelyn Olney , Whalen Cara E , Smith Jennifer A , Schacht Walter H , Tyre Andrew J , Benson John F , Brown Mary Bomberger , Powell Larkin A 
Published: July 2019

AbstractOver the last century, increasing human populations and conversion of grassland to agriculture have had severe consequences for numbers of Greater Prairie-Chicken (Tympanuchus cupido). Understanding Greater Prairie-Chicken response to human disturbance, including the effects of anthropogenic noise and landscape modification, is vital for conserving remaining populations because these disturbances are becoming more common in grassland systems. Here, we evaluate the effect of low-frequency noise emitted from a wind energy facility on habitat selection. We used the Normalized Difference Soundscape Index, a ratio of human-generated and biological acoustic components, to determine the impact of the dominant acoustic characteristics of habitat relative to physical landscape features known to influence within–home range habitat selection. Female Greater Prairie-Chickens avoided wooded areas and row crops but showed no selection or avoidance of wind turbines based on the availability of these features across their home range. Although the acoustic environment near the wind energy facility was dominated by anthropogenic noise, our results show that acoustic habitat selection is not evident for this species. In contrast, our work highlights the need to reduce the presence of trees, which have been historically absent from the region, as well as decrease the conversion of grassland to row-crop agriculture. Our findings suggest physical landscape changes surpass altered acoustic environments in mediating Greater Prairie-Chicken habitat selection.
Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis
Authors: Banerjee Amitava , Allan Victoria , Denaxas Spiros , Shah Anoop , Kotecha Dipak , Lambiase Pier D , Joseph Jacob , Lund Lars H , Hemingway Harry 
Published: July 2019

AbstractAimsTo evaluate population-based electronic health record (EHR) definitions of atrial fibrillation (AF) and valvular heart disease (VHD) subtypes, time trends in prevalence and prognosis.Methods and resultsA total of 76 019 individuals with AF were identified in England in 1998–2010 in the CALIBER resource, linking primary and secondary care EHR. An algorithm was created, implemented, and refined to identify 18 VHD subtypes using 406 diagnosis, procedure, and prescription codes. Cox models were used to investigate associations with a composite endpoint of incident stroke (ischaemic, haemorrhagic, and unspecified), systemic embolism (SSE), and all-cause mortality. Among individuals with AF, the prevalence of AF with concomitant VHD increased from 11.4% (527/4613) in 1998 to 17.6% (7014/39 868) in 2010 and also in individuals aged over 65 years. Those with mechanical valves, mitral stenosis (MS), or aortic stenosis had highest risk of clinical events compared to AF patients with no VHD, in relative [hazard ratio (95% confidence interval): 1.13 (1.02–1.24), 1.20 (1.05–1.36), and 1.27 (1.19–1.37), respectively] and absolute (excess risk: 2.04, 4.20, and 6.37 per 100 person-years, respectively) terms. Of the 95.2% of individuals with indication for warfarin (men and women with CHA2DS2-VASc ≥1 and ≥2, respectively), only 21.8% had a prescription 90 days prior to the study.ConclusionPrevalence of VHD among individuals with AF increased from 1998 to 2010. Atrial fibrillation associated with aortic stenosis, MS, or mechanical valves (compared to AF without VHD) was associated with an excess absolute risk of stroke, SSE, and mortality, but anticoagulation was underused in the pre-direct oral anticoagulant (DOAC) era, highlighting need for urgent clarity regarding DOACs in AF and concomitant VHD.
Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice
Authors: Pagnamenta Alistair T , Heemeryck Pierre , Martin Hilary C , Bosc Christophe , Peris Leticia , Uszynski Ivy , Gory-Fauré Sylvie , Couly Simon , Deshpande Charu , Siddiqui Ata , Elmonairy Alaa A ,   WGS500 Consortium,   Genomics England Research Consortium, Jayawant Sandeep , Murthy Sarada , Walker Ian , Loong Lucy , Bauer Peter , Vossier Frédérique , Denarier Eric , Maurice Tangui , Barbier Emmanuel L , Deloulme Jean-Christophe , Taylor Jenny C , Blair Edward M , Andrieux Annie , Moutin Marie-Jo 
Published: July 2019

Abstract
Reversible detyrosination of tubulin, the building block of microtubules, is crucial for neuronal physiology. Enzymes responsible for detyrosination were recently identified as complexes of vasohibins (VASHs) one or two with small VASH-binding protein (SVBP). Here we report three consanguineous families, each containing multiple individuals with biallelic inactivation of SVBP caused by truncating variants (p.Q28* and p.K13Nfs*18). Affected individuals show brain abnormalities with microcephaly, intellectual disability and delayed gross motor and speech development. Immunoblot testing in cells with pathogenic SVBP variants demonstrated that the encoded proteins were unstable and non-functional, resulting in a complete loss of VASH detyrosination activity. Svbp knockout mice exhibit drastic accumulation of tyrosinated tubulin and a reduction of detyrosinated tubulin in brain tissue. Similar alterations in tubulin tyrosination levels were observed in cultured neurons and associated with defects in axonal differentiation and architecture. Morphological analysis of the Svbp knockout mouse brains by anatomical magnetic resonance imaging showed a broad impact of SVBP loss, with a 7% brain volume decrease, numerous structural defects and a 30% reduction of some white matter tracts. Svbp knockout mice display behavioural defects, including mild hyperactivity, lower anxiety and impaired social behaviour. They do not, however, show prominent memory defects. Thus, SVBP-deficient mice recapitulate several features observed in human patients. Altogether, our data demonstrate that deleterious variants in SVBP cause this neurodevelopmental pathology, by leading to a major change in brain tubulin tyrosination and alteration of microtubule dynamics and neuron physiology.