bluuebunny/crossref_metadata_2025_split huggingface dataset:
As formas de expressão da modalidade volitiva nos discursos do Papa Francisco em viagem apostólica
Authors: Oliveira André Silva , Prata Nadja Paulino Pessoa 
Published: June 2019

Este artigo apresenta uma descrição e análise das formas de expressão usadas para a instauração da modalidade volitiva em língua espanhola com base nos discursos do Papa Francisco em viagem apostólica, tendo em vista a proposta tipológica da categoria modalidade apresentada na Gramática Discursivo-Funcional (GDF) e os diversos estudos sobre essa categoria em língua espanhola (SEDANO, 2006; GARCÍA, 2009; TOPOR, 2011; GARCÍA, 2013; e OLIVEIRA, 2017). Os resultados revelam que as construções volitivas foram as mais empregadas (34,2%), seguida pelos usos de verbo pleno (29,1%) e auxiliar modal (24,8%). O emprego majoritário das construções volitivas se dá em virtude do modo subjuntivo, que é o modo verbal prototípico para a instauração das modalizações volitivas relacionadas à manifestação da desejabilidade de potencialização de algum evento volitivo, geralmente, em relação a algo do qual o Sumo Pontífice não teria controle. Há ainda a proposta de que as orações finais, com a estruturação “para...+para que+subjuntivo”, se prestem à expressão da modalidade volitiva, em que há uma vinculação de um dado estados-de-coisas expresso com base em uma intenção (volição), com prospectividade futura, de caracterização hipotética e para expressar um desejo pessoal do Sumo Pontífice.
Impropriedades lexicais em textos de estudantes universitários
Authors: Gil Beatriz Daruj 
Published: June 2019

Professores universitários estão insatisfeitos com o desempenho linguístico-acadêmico de seus alunos. Os estudantes alegam que não sabem escrever, que são mal avaliados em suas produções e, finalmente, que desconhecem a saída para o problema. Em estudos a respeito do letramento (BARTON, 2000; GEE, 2004; LEA e STREET, 2014; STREET, 2003), afirma-se que todos, ao ingressarem na universidade, já possuem conhecimento advindo de vários letramentos anteriores e que, no contexto universitário, precisariam apenas conhecer a norma dos gêneros acadêmicos. A despeito do desconhecimento das convenções do gênero acadêmico, defende-se, neste artigo, que alunos universitários também desconhecem tópicos sobre o funcionamento linguístico-discursivo da língua, o que seria uma razão importante para seu baixo desempenho linguístico. Em função dessa hipótese, analisa-se um conjunto de produções escritas de alunos universitários com o objetivo de identificar impropriedades lexicais que podem contribuir para a avaliação negativa dos textos por eles produzidos.
Immunoenhancement of Recombinant Neisseria meningitides PorB Protein on Porcine Circovirus Type 2 and Mycoplasma hyopneumoniae Genetically Engineered Vaccines
Authors: Yang Rui , Tao Yu , Li Gaojian , Chen Jian , Shu Jianhong , He Yulong 
Published: June 2019

Background:Porcine circovirus and Mycoplasma hyopneumoniae can cause respiratory diseases in pigs, which cause serious economic loss in the worldwide pig industry. Currently, these infections are mainly prevented and controlled by vaccination. The new vaccines on the market are mainly composed of subunits and inactivated vaccines but usually have lower antigenicity than traditional live vaccines. Thus, there is an increasing need to develop new adjuvants that can cause rapid and long-lasting immunity to enhance the antigenic efficacy for vaccines. Studies have shown that meningococcal porin PorB can act as a ligand to combine with Toll-like receptors to activate the production of immunological projections and act as a vaccine immunological adjuvant.Objective:In this article, we expressed and purified the recombinant PorB protein and verified its immunogenicity against porcine circovirus type 2 and Mycoplasma hyopneumoniae genetically engineered vaccine.Methods:In this article, we used prokaryotic expression to express and purify recombinant PorB protein, four different concentrations of PorB protein, Freund's adjuvant with two genetically engineered vaccines were combined with subcutaneous immunization of mice.Results:Our study shows that the appropriate dose of the recombinant protein PorB can enhance the levels of humoral and cellular responses induced by two genetically engineered vaccines in a short period of time in mice. The PorB adjuvant group may cause statistically higher antibody titers for both genetically engineered vaccines compared to Freund's commercial adjuvant (P<0.001).Conclusion:The recombinant protein PorB may be a good candidate adjuvant for improving the protective effect of vaccines against porcine circovirus type 2 and Mycoplasma hyopneumoniae, and the protein can be used for future practical applications.
Diabetic Hemodialysis: Vitamin D Supplementation and its Related Signaling Pathways Involved in Insulin and Lipid Metabolism
Authors: Hosseini Elahe S. , Kashani Hamed H. , Nikzad Hossein , Soleimani Alireza , Mirzaei Hamed , Tamadon Mohammd R. , Asemi Zatollah 
Published: June 2019

Background:This study was conducted to determine the effects of vitamin D supplementation on some of the gene expressions related to insulin and lipid metabolism in diabetic hemodialysis (HD) patients.Methods:A double-blind, randomized, placebo-controlled clinical trial was carried out in 55 patients with diabetic HD. The current project used two groups in which each subject received vitamin D supplements (50,000 IU, n=28) or placebo (50,000 IU, n=27) every 2 weeks for 12 weeks. Gene expression analyses (RT-PCR) were included to obtain the rate of gene expression of the related insulin and lipid metabolism genes in peripheral blood mononuclear cells (PBMCs) of patients with diabetic HD.Results:Our data revealed that consumption of vitamin D supplementation enables to overexpress the peroxisome proliferation-activated receptor gamma (PPAR-γ) (P=0.001), AKT (P=0.04), PI3K (P=0.02), insulin receptor substrate-1 (IRS1) (P0.008) and glucose transporter type 4 (GLUT-4) (P=0.01) and downregulate the expression of protein kinase C (PKC) (P=0.001) in patients with diabetic HD than control group following the 12-week intervention. In addition, vitamin D supplementation downregulated low-density lipoprotein receptor (LDLR) (P=0.03) expression in the subjects with diabetic HD than the control group. Vitamin D supplementation did not show any effects on the expression of pyruvate dehydrogenase kinase 1 (PDK1) (P=0.37), IRS2 (P=0.90) and lipoprotein (a) [Lp(a)] (P=0.05).Conclusions:Our findings confirmed that diabetic HD subjects who received the vitamin D supplementation (for 12 weeks), showed a significant overexpression in the PPAR-γ, AKT, PI3K, IRS1 and GLUT4 genes, and also showed a significant downregulation in the PKC and LDLR genes. Moreover, no effects on PDK1, IRS2 and Lp(a) expression were observed.
In Vitro and In Silico Studies of Glycyrrhetinic Acid Derivatives as Anti- Filarial Agents
Authors: Tyagi Rekha , Verma Surjeet , Mishra Shikha , Srivastava Mrigank , Alam Sarfaraz , Khan Feroz , Srivastava Santosh Kumar 
Published: June 2019

Background:
Lymphatic filariasis is one of the chronic diseases in many parts of the tropics
and sub-tropics of the world despite the use of standard drugs diethylcarbamazine and ivermectin because
they kill microfilaries and not the adult parasites. Therefore, new leads with activity on adult parasites are
highly desirable.

Objective:
Anti-filarial lead optimization by semi-synthetic modification of glycyrrhetinic acid (GA).

Methods:
The GA was first converted into 3-O-acyl derivative, which was further converted into 12 amide
derivatives. All these derivatives were assessed for their antifilarial potential by parasite motility assay.
The binding affinity of active GA derivatives on trehalose-6-phosphate phosphatase (Bm-TPP) was
assessed by molecular docking studies.

Results:
Among 15 GA derivatives, GAD-2, GAD-3, and GAD-4 were found more potent than the GA
and standard drug DEC. These derivatives reduced the motility of Brugia malayi adult worms by up to
74% while the GA and DEC reduced only up to 49%. Further, GA and most of its derivatives exhibited
two times more reduction in MTT assay when compared to the standard drug DEC. These derivatives
also showed 100% reduction of microfilariae and good interactions with Bm-TPP protein.

Conclusion:
The present study suggests that 3-O-acyl and linear chain amide derivatives of glycyrrhetinic
acid may be potent leads against B. malayi microfilariae and adult worms. These results might be
helpful in developing QSAR model for optimizing a new class of antifilarial lead from a very common,
inexpensive, and non toxic natural product.
Improvement in Diabetic Control Belief in Relation to Locus of Control
Authors: Haskas Yusran , Suryanto Yusran , Suarnianti Yusran 
Published: June 2019

Background:

Adherence to diabetes control is important to determine an individual’s ability to maintain treatment focus of Diabetes Mellitus . The Locus of Control thereby assesses the behavior of an individual to diabetes control.

Objective:
The aim of this study was to analyze the pathways of diabetes control beliefs based on the variable locus of control in the integration of locus of control theory and the theory of planning behavior on diabetes mellitus control behavior.

Methods:
This study was carried out as an explanatory research with a cross-sectional design. The sampling technique was consecutive. The sample size was determined using multivariate numerical analytic one-time predictive concept framework and 143 respondents at 8 locations were recruited by a random lottery method. Demographic data analysis of respondents was done using statistical software, namely IBM Statistics SPSS using a Chi-square statistical test. The proposed hypothesis was tested by the bivariate analysis of variance to assess the effect of causal variables.

Results:
The results of this study indicate that locus of control affects diabetic control beliefs (ρ = 0.05; α = 0.06; b = 0.16; b2 = 0.03; F = 3.91) in the diabetes mellitus control behavior.

Conclusion:
The findings of this study suggest a need to consistently provide positive information and support as a locus of control to guard a strong intention to control diabetes mellitus.
The Emergency Assessment and Management of Non-Suicidal Self-Injury in Adolescents
Authors: Idicula Sindhu A. , Vyas Amy , Garber Nicole 
Published: June 2019

Background and Goals:
Non-suicidal self-injury (NSSI) is a common presenting
issue mental health providers experience in all levels of care from outpatient clinics to inpatient
units. It is common among adolescents seen in emergency settings, either as a presenting
problem or as a covert condition that may not be detected unless specifically assessed
for. The presence of NSSI increases the risk of suicide. This article aims to help the clinician
develop a better understanding of NSSI – what it may entail, the prevalence, and the motivations
for why young people engage in it.

Methods:
We review the reasons adolescents injure themselves, the link between NSSI and
psychiatric diagnoses and suicide, the assessment of NSSI, and treatment planning, with emphasis
on ways to screen for NSSI and interventions that can be implemented in the Emergency
Department. We illustrate the complexity of NSSI with the case of a young patient
with a complex psychiatric history and an extensive history of self-injury.

Results and Discussion:
Despite the seeming intractability of NSSI, a number of evidencebased
treatments exist. Treatment primarily involves specialized forms of psychotherapy, but
interventions can be implemented in the ED that will reduce the immediate risk of NSSI
while more definitive intervention is awaited.

Conclusion:
Mental health consultations in the ED should always include screening for
NSSI. Mental health professionals in the ED can play an important role in the detection and
treatment of this condition.
Social Support Patterns of Middle-Aged and Older Adults Within a Physical Activity App: Secondary Mixed Method Analysis
Authors: Lewis Zakkoyya H , Swartz Maria C , Martinez Eloisa , Lyons Elizabeth J 
Published: June 2019

Background
Physical activity (PA) is critical for maintaining independence and delaying mobility disability in aging adults. However, 27 to 44% of older adults in the United States are meeting the recommended PA level. Activity trackers are proving to be a promising tool to promote PA adherence through activity tracking and enhanced social interaction features. Although social support has been known to be an influential behavior change technique to promote PA, how middle-aged and older adults use the social interaction feature of mobile apps to provide virtual support to promote PA engagement remains mostly underexplored.

Objective
This study aimed to describe the social support patterns of middle-aged and older adults using a mobile app as part of a behavioral PA intervention.

Methods
Data from 35 participants (mean age 61.66 [SD 6] years) in a 12-week, home-based activity intervention were used for this secondary mixed method analysis. Participants were provided with a Jawbone Up24 activity monitor and an Apple iPad Mini installed with the UP app to facilitate self-monitoring and social interaction. All participants were given an anonymous account and encouraged to interact with other participants using the app. Social support features included comments and likes. Thematic coding was used to identify the type of social support provided within the UP app and characterize the levels of engagement from users. Participants were categorized as superusers or contributors, and passive participants were categorized as lurkers based on the literature.

Results
Over the 12-week intervention, participants provided a total of 3153 likes and 1759 comments. Most participants (n=25) were contributors, with 4 categorized as superusers and 6 categorized as lurkers. Comments were coded as emotional support, informational support, instrumental support, self-talk, and other, with emotional support being the most prevalent type.

Conclusions
Our cohort of middle-aged and older adults was willing to use the social network feature in an activity app to communicate with anonymous peers. Most of our participants were contributors. In addition, the social support provided through the activity app followed social support constructs. In sum, PA apps are a promising tool for delivering virtual social support to enhance PA engagement and have the potential to make a widespread impact on PA promotion.

Trial Registration
ClinicalTrials.gov NCT01869348; https://clinicaltrials.gov/ct2/show/NCT01869348
Preformed Donor-Specific HLA Antibodies in Living and Deceased Donor Transplantation
Authors: Ziemann Malte , Altermann Wolfgang , Angert Katharina , Arns Wolfgang , Bachmann Anette , Bakchoul Tamam , Banas Bernhard , von Borstel Annette , Budde Klemens , Ditt Vanessa , Einecke Gunilla , Eisenberger Ute , Feldkamp Thorsten , Görg Siegfried , Guthoff Martina , Habicht Antje , Hallensleben Michael , Heinemann Falko M. , Hessler Nicole , Hugo Christian , Kaufmann Matthias , Kauke Teresa , Koch Martina , König Inke R. , Kurschat Christine , Lehmann Claudia , Marget Matthias , Mühlfeld Anja , Nitschke Martin , Pego da Silva Luiza , Quick Carmen , Rahmel Axel , Rath Thomas , Reinke Petra , Renders Lutz , Sommer Florian , Spriewald Bernd , Staeck Oliver , Stippel Dirk , Süsal Caner , Thiele Bernhard , Zecher Daniel , Lachmann Nils 
Published: June 2019

Background and objectives
The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation.

Design, setting, participants, & measurements
The outcome of 4233 consecutive kidney transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most centers used a stepwise pretransplant antibody screening with bead array tests and differentiation of positive samples by single antigen assays. Using these screening results, DSA against HLA-A, -B, -C, -DRB1 and -DQB1 were determined. Data on clinical outcome and possible covariates were collected retrospectively.

Results
Pretransplant DSA were associated with lower overall graft survival, with a hazard ratio of 2.53 for living donation (95% confidence interval [95% CI], 1.49 to 4.29; P<0.001) and 1.59 for deceased donation (95% CI, 1.21 to 2.11; P=0.001). ABO-incompatible transplantation was associated with worse graft survival (hazard ratio, 2.09; 95% CI, 1.33 to 3.27; P=0.001) independent from DSA. There was no difference between DSA against class 1, class 2, or both. Stratification into DSA <3000 medium fluorescence intensity (MFI) and DSA ≥3000 MFI resulted in overlapping survival curves. Therefore, separate analyses were performed for 3-month and long-term graft survival. Although DSA <3000 MFI tended to be associated with both lower 3-month and long-term transplant survival in deceased donation, DSA ≥3000 MFI were only associated with worse long-term transplant survival in deceased donation. In living donation, only strong DSA were associated with reduced graft survival in the first 3 months, but both weak and strong DSA were associated with reduced long-term graft survival. A higher incidence of antibody-mediated rejection within 6 months was only associated with DSA ≥3000 MFI.

Conclusions
Preformed DSA were associated with an increased risk for graft loss in kidney transplantation, which was greater in living than in deceased donation. Even weak DSA <3000 MFI were associated with worse graft survival. This association was stronger in living than deceased donation.
Pemahaman Guru Bahasa Indonesia SMP dan SMA dalam Mengembangkan Butir-butir Pembelajaran Kebahasaan dengan Pendekatan Komunikatif Berbasis Teks
Authors: Harahap Eddy Pahar 
Published: June 2019

Tahun 2013 telah diberlakukan kurikulum 2013. Perubahan kurikulum ini terletak proses kegiatan. Kegiatan dikembangkan untuk mengembangkan potensi berbahasa, kognisi, kepribadian, dan emosi siswa. Dalam mengembangkan potensi tersebut, pendekatan yang dipakai adalah komunikatif berbasis teks. Salah-satu pembelajaran bahasa Indonesia adalah butir-butir pembelajaran kebahasan. Oleh karena itu, guru diharapkan mengembangkan butir-butir kebahasaan dengan pendekatan komunikatif berbasis teks.
Subjek penelitian adalah guru-guru Bahasa Indonesia SMP dan SMA Negeri Kota Kuala Tungkal. Dasar pengambilan subjek guru-guru bahasa Indonesia di kota Kuala Tungkal; sudah mendapat pelatihan Kurikulum 2013, dan aktif dalam kegiatan MGMP Bahasa Indonesia. Hasil penelitian dikemukakan, sebagai berikut; (1) guru mengembangkan butir-butir pembelajaran kebahasan bertumpuh pada teks, (2) guru mengembangkan butir-butir pembelajaran kebahasan metode diskusi lalu siswa mengambil contoh dalam teks di buku siswa, (3) guru mengembangkan butir-butir pembelajaran kebahasan dengan metode tanya-jawab, dan contoh bermula dari guru, siswa berdiskusi mencari contoh lain, dan (4) guru mengembangkan butir-butir pembelajaran kebahasan dengan metode tanya jawab kepada siswa dan siswa menjawab secara individu.
Kurikulum bahasa Indonesia 2013 pada pendekatan berbasis teks. Oleh karena itu, diharapkan guru mengembangkan mencari contoh-contoh dalam wacana atau teks-teks dalam buku. Tujuannya dengan belajar butir-butir kebahasaan, dapat membantu siswa meningkatkan minat literasi sesuai dengan filosofi kurikulum tersebut.
Meningkatkan Kemampuan Bercerita Fabel Bahasa Indonesia melalui Media Boneka pada Siswa Kelas VII SMP
Authors: . Anggraini 
Published: June 2019

Abstrak
Penelitian ini berawal dari rendahnya kemampuan Berbicara, pembelajaran menceritakan kembali Fabel yang dibaca/didengar peserta didik kelas VII di SMP N 4 Jambi. Tujuan penelitian ini meningkatkan keterampilan, motivasi dan membantu peserta didik mengatasi kesulitan dalam bercerita fabel, dengan menggunakan media boneka.Penelitian ini dilakukan dengan 2 (dua) siklus dengan masing-masing siklus dirancang 4 (empat) kegiatan, yaitu tahap perencanaan, pelaksanaan, pengamatan, serta refleksi. Data diambil dengan menggunakan instrument lembar pengamatan, data tampilan unjuk kerja atau hasil belajar peserta didik, sikap, dan pengetahuan. Analisis data secara deskriptif dengan teknik persentase. Hasil observasi guru menyatakan aktivitas peserta didik mengalami peningkatan hasil belajar dari Siklus I , siklus I, dan siklus II, yaitu aspek keterampilan 55,60%, aspek sikap 30,49%, aspek pengetahuan 71,34%. Penggunaan media Boneka meningkatkan keterampilan, motivasi, dan aktivitas belajar peserta didik.

Kata kunci: Media Boneka, Keterampilan Bercerita Fabel Bahasa Indonesia

Abstract
This research started from the low ability to speak, The lesson recounts the fable that are read/heard by 7th graders at junior high school 4 Jambi, The purpose of this research is increasing skills, motivation, and helping the learners to overcome difficulties in telling fables by using the puppet medium, This research was conducted with 2 (two) cycles with each cycles was designed 4 (four) activities that is planning, implementation, observation and reflection, Data was taken with using instrument observation sheet, data display performance or learning outcomes of learners, attitude, and knowledge. Analysis of data descriptively with percentage technique. The result of teacher observation claim the activities of learners have increased learning outcomes from precycle, cycle I, cycle II, that is skill aspect 55,60%, attitude ascpect 30,49%, knowledge aspect 71,34%. The use puppet media enchances motivation skill and learning activity of learners.

Keywords: Puppet media, the skill of telling Indonesian fables
Increasing Chlamydia Testing Rates via Targeted Outreach
Authors: Badarane Deyze , Knox Jordan , Camacho Ana , Magill Michael K. , Van Hala Sonja , Jones Jessica L. 
Published: June 2019

Background and Objectives: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) in the United States. Annual chlamydia screening of asymptomatic, sexually active women age 16 to 24 years and of older women who are at increased risk for infection is recommended. This study built on prior work in which our university-based family medicine clinic implemented quality improvement (QI) interventions in 2016 and 2017 to increase our chlamydia screening rate. Our primary aim in the current study was to increase the screening rate by 10%. Our secondary aim was to determine the number of patient contacts that yielded maximum test rates.
Methods: For the most recent QI cycle, we conducted a prospective cohort study from December 2017 through March 2018. Using the FOCUS-PDSA model, a resident-led, interdisciplinary QI team developed the aims and implemented an intervention to streamline patient outreach. We also retrospectively analyzed data from the previous QI cycle to determine the number of tests obtained after each patient contact.
Results: Chlamydia testing increased from 54% to 56.3% between December 2017 and March 2018. The majority of tests were completed by four patient contacts; additional contacts yielded few additional tests.
Conclusions: Persistent outreach increases chlamydia screening rates. This QI project could be replicated in other clinical settings to improve the screening of chlamydia or other diseases.
“A FORÇA DA JUVENTUDE GARANTE O FUTURO DE UM POVO”: A EDUCAÇÃO DO CORPO NO SPORT CLUB GERMANIA (1899-1938)
Authors: Amgarten Quitzau Evelise , Soares Carmen Lúcia 
Published: June 2019

Este estudo teve como objetivo compreender as práticas corporais desenvolvidas no Sport Club Germania e observar suas possíveis relações com a ginástica desenvolvida largamente na Alemanha ao longo do século XIX, século que marca um período de intensa imigração europeia em direção ao Brasil. Dentre as ondas migratórias que aqui chegaram, podemos destacar as alemãs que, embora mais intensas na região sul, também tiveram grande importância na formação de São Paulo. Entre as variadas instituições fundadas por tais imigrantes na capital paulista, os clubes tiveram grande destaque como referências tanto para a prática de exercícios físicos quanto para a manutenção das tradições germânicas.