bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Of Life and Associated Factors among Patients with Major Depression on Follow Up At Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia
Authors: enkoyee dessalegn kiross , Angaw Dessie Abebaw , Abady Gdiom Gebreheat , Ayalew Getnet Dessie , wondiefraw abriham zegeye 
Published: October 2019

Abstract
Background: Patients suffering from major depression are reported to have poorer quality of life than both the general population and otherwise healthy persons with chronic diseases. The impact of major depression on quality of life is scarcely investigated in developing country.Methods : An institution based cross-sectional study was conducted from March 15 to April 16, 2017 at Amanuel Mental Specialized Hospital. 502 study participants were involved in the study. Quality of life was measured by a structured cross-cultural WHOQOL-BREF. Other tools utilized in this study were Montgomerry-Asberg depression rating scale, Oslo social support scale, and Jacoby perceived stigma scale. Multiple linear regression analysis was used to predict the effect of each factor on domains of quality of life.Result : The mean score QOL for each domain (mean± SD) was, for physical 43.5±11.9, for psychological 41.2±11.9, for social 40.7±10.6, and for environmental 41.3±9.6. Univariate analysis showed nearly half of the participants scored below the mean score quality of life (QOL). Multiple regression analysis depicted severity of depressive symptoms was strongly negatively correlated with all domains of QOL. It had predicted above 50% of the variability in each domain. Social support was also another strong predictor which was negatively correlated with all QOL domains, except environmental. It had explained above 60% of the variance in physical, and 43.3% for psychological and 44.8% for social domain.Conclusion: The results shows mean score QOL in each domain is lower compared to other studies, and even nearly half the participants are below the mean score QOL. Severity of depressive symptoms, social support, numbers of episodes in a year, duration on treatment, stigma, being single and rural residence are factors negatively correlated with at least one domain. Treating Major depression should follow a holistic approach and should aim in improving QOL. Keywords: Major Depressive Disorder , Quality of life, WHOQOL-BREF, Associated factor
The retinal lesions in ultra-wide-field retinal imaging and the consistency of different fundus screening methods in HIV/AIDS patients
Authors: Du Kuifang , Chen Chao , Guo Chungang , Dong Hongwei , Xie Lian-yong , Kong Wenjun , Wei Wen Bin 
Published: October 2019

Abstract
Background: To observe the retinal lesions in HIV/AIDS patients and to evaluate the consistency of non-mydriatic ultra-wide-field (UWF) retinal imaging and mydriatic slit lamp biomicroscope with Superfield lens. Methods: 193 eyes of 98 consecutive HIV/AIDS patients were enrolled. The retinal lesions in each patients were observed through UWF fundus imaging and slit lamp biomicroscopic with Superfield lens whose consistency was analyzed. Results: 100 eyes (51.8%） had fundus lesions, 20 eyes (20%) presented posterior microvascular retinopathy (MVR), 19 eyes (19%) presented peripheral MVR, 15 eyes (15%) presented early stage cytomegalovirus retinitis (CMVR), 6 eyes showed initial stage CMVR, and 51 eyes showed other changes (papilledema, etc.). The consistency of two methods was moderate in detecting the isolated peripheral lesions (Kappa = 0.445) or HIV-related MVR (Kappa = 0.513), and high in inspecting the posterior/posterior involved lesions (Kappa = 0.831) or CMVR (Kappa = 1.0). The detection rate of UWF retinal imaging and slit lamp biomicroscopic were 15.5%（30/193）and 17.6%（34/193）(P=0.557＞0.05) for HIV-related MVR, 7.8% (15/193) (P=1.000＞0.05) for CMVR, 37.3% (72/193) and 33.7% (65/193) (P=0.118＞0.05) for posterior/posterior involved lesions, 8.8% (17/193) and 17.6% (34/193) (P=0.001＜0.05) for isolated peripheral lesions , respectively. Conclusions: The HIV-related MVR can be posterior or peripheral. Various fundus changes appear in HIV/AIDS patients, not only MVR or CMVR. The non-mydriatic UWF fundus imaging system and mydriatic slit lamp biomicroscope exhibited good consistency and nondiscriminatory detection rate for CMVR, HIV-related MVR and posterior lesions, but not for isolated peripheral lesions.
Intravenous Vitamin D Receptor Activators in Dialysis Introduction Period
Authors: Koshi-Ito Eri , Inaguma Daijo , Koide Shigehisa , Takahashi Kazuo , Hayashi Hiroki , Tsuboi Naotake , Hasegawa Midori , Yuzawa Yukio 
Published: October 2019

Abstract
Background Usage of vitamin D receptor activator (VDRA) for chronic kidney disease (CKD) including patients on dialysis patients has been controversial yet. It is unknown when to begin or discontinue VDRA therapy, the type of VDRA to administer, and the method of delivery, intravenous or oral for survival in CKD patients. Therefore, we examined whether intravenous or oral VDRA early after dialysis initiation affected mortality in incident dialysis patients. Methods The study database was derived from the Aichi Cohort Study of Prognosis in Patients Newly Initiated into Dialysis (AICOPP), a multicenter, prospective, cohort analysis of 1,520 consecutive patients who began dialysis at the 17 AICOPP group centers between October 2011 and September 2013. We excluded the 262 patients who died by March 2015, 15 patients were lost to follow-up, 241 patients with unconfirmed information about use of VDRA in March 2015, and 35 patients who discontinued VDRA between dialysis initiation and March 2015. Finally, 967 patients participated in the present study. We classified the participating patients into three groups according to the usage of VDRA in March 2015: no use of VDRA (NV group), oral VDRA (OV group), and intravenous VDRA (IV group) and compared their all-cause mortality. Results There were 104 deaths during the follow-up period (NV group, 27 cases; OV group, 53 cases; IV group, 24 cases). Significant differences between the cumulative survival rates were observed for the three groups (p = 0.010). The IV group was associated with low all-cause mortality compared to the NV group (Hazard ratio = 0.46, 95% CI = 0.24−0.89, p = 0.020) by multivariate Cox proportional hazard analysis using the stepwise method. Conclusions Our study shows that early introduction of intravenous VDRA to patients on hemodialysis seems to be associated with better prognosis.Trial Registration The trial registration no. is UMIN 000007096, registered on January 18, 2012. 298words, Text: 2967 words
Blood systemic inflammatory markers in adult brucella knee arthritis
Authors: Adanas Cihan , Aslan Mehmet 
Published: October 2019

Abstract
Background: Mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) have been documented as blood biomarkers of systemic inflammation. The aim of the current research was to examine these blood biomarkers in brucella knee arthritis.

Methods: Fifty-three brucella knee arthritis subjects and 42 healthy subjects were included . The erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) levels were compared. White blood cells (WBC), MPV, platelet, neutrophil, and lymphocyte counts were determined from complete blood counts. The PLR and NLR were calculated.

Results: We found that CRP, ESR, and MPV levels were considerably increased in brucella knee arthritis than control groups (p<0.001, p=0.024, p=0.024). Moreover, the brucella arthritis patients had lower NLR and neutrophil counts compared to the control participants (p=0.027, p=0.007). According to the Pearson’s correlation analysis, the serum agglutination tests with titers were positively related to the lymphocyte counts (p=0.009, r=0.355) in the patients.

Conclusions: We observed statistically significant differences between the brucella knee arthritis patients and the healthy subjects with respect to MPV and NLR. These parameters may be beneficial markers in the assessment of systemic inflammation in patients with brucella arthritis.
The Educational Needs of Family of the Patients Discharged from the Intensive Care Units: The Viewpoints of Nurses and the patients’ Families
Authors: Hajalizadeh Asma , Ahmadinejad Mehdi , Dehghan Mahlagha , Arab Mansoor 
Published: October 2019

Abstract
Objectives This study aimed to determine the educational needs of the families of patients discharged from the intensive care units and to compare the views of families and nurses about these needs.Method This was a cross-sectional study. Two hundred eighty nurses and family members of the patients discharged from the intensive care units participated in the survey. A researcher-made questionnaire about the educational needs of the family were used for data collection.Results Nurses significantly estimated the educational needs of families more than what they did (P <0.001). The families and nurses reported the educational needs of self-care as well as nutrition and medicine at the highest level, respectively. Both groups reported the educational needs of defecation at the lowest level.Conclusion Given the high level of family needs, implementing educational and practical interventions is necessary to enhance their skills.
Topography-guided transepithelial accelerated corneal collagen cross-linking for low refractive error correction in keratoconus treatment: a pilot study
Authors: Sun Ling , Zhao Yu , Zhang Xiaoyu , Tian Mi , Zhao Jing , Zhou Xingtao 
Published: October 2019

Abstract
Purpose To investigate the safety and efficacy of topography-guided transepithelial accelerated corneal collagen cross-linking for low refractive error correction in keratoconus patients. Methods This was a prospective self-controlled study. Eighteen patients (18 eyes) were enrolled and assessed at 6 visits (pre-operation, 1 d, 1 m, 3 m, 6 m and 1 y post-operation). The examination at every visit included analysis of un-corrected visual acuity (UCVA), best corrected visual acuity (BCVA), corneal topography and corneal endothelial cell counts. Data are expressed as the mean ± standard deviation (SD). The P-value was determined using repeated measures ANOVA. Results No complications occurred in any of the eyes throughout the entire follow-up period. At each visit after the operation, the corneal K values and spherical equivalent (SE) were reduced, while visual acuity values were increased compared with those pre-operation, although these results were not statistically significant. During the follow-up, corneal endothelial cell counts were stable. Regarding the topography, part of the corneal cone was flattened after the operation. Conclusion Topography-guided transepithelial accelerated corneal collagen cross-linking is safe and may correct low refractive error in keratoconus treatment. Further studies and improvement are needed.
Economic incentives for water consumption reduction: case study of the city of São Paulo, Brazil
Authors: de Sousa Cláudia Orsini M. , Dias Fouto Nuno M. M. 
Published: October 2019

Abstract
There are numerous studies regarding water pricing, demand and elasticity for certain regions. However, in Brazil, there are no studies on these matters, even though there is a need to explore the behavior of Brazil's population, especially because the nation is susceptible to extreme water events. São Paulo State, Brazil's most important economic region, has recently experienced a severe water scarcity status. In an attempt to control water demand, the São Paulo Water Agency (SABESP) implemented a ‘bonus and onus’ program. In this context, the aim of this study was to analyze the SABESP programs in terms of their structures and results using a panel model. The econometric results showed that (i) the bonus program was successful and more effective than the onus program, and (ii) water consumption reduction was more significant in regions supplied by water reservoirs where the relative water level was lower, although inhabitants of other regions also reduced their water consumption.
Infectious rain? Evaluation of human pathogen concentrations in stormwater in separate sewer systems
Authors: Schreiber Christiane , Heinkel Sophie-Bo , Zacharias Nicole , Mertens Franz-Michael , Christoffels Ekkehard , Gayer Uta , Koch Christoph , Kistemann Thomas 
Published: October 2019

AbstractSeparate sewer systems collect and discharge rainwater directly into surface water bodies. In residential areas covering moderate traffic load these are alternative drainage routes to avoid combined sewer overflow discharge and to keep rivers clean as required by the EU Water Framework Directive. This overflow's microbial quality, however, needs to be evaluated, since stormwater run-offs are potential pathways for pathogens into river systems. Between 2010 and 2016, two separate sewer systems in North Rhine-Westphalia (Germany) were investigated. The stormwater outflow was sampled during discharge events and microbiologically analysed. The results showed high concentrations of Escherichia coli (1,100–1,100,000 CFU/100 mL) and Clostridium perfringens (20–13,000 CFU/100 mL). Campylobacter and Salmonella were detected in 97% and 43% of the samples. Giardia cysts were more often detected (31.6%) than Cryptosporidium oocysts (10.5%). The sources of human pathogens in rainwater run-off are heterogeneous. While roads have already been declared as chemical polluters via rainwater run-off, our study detected supplementary pollution of mainly faecal microorganisms. Presumably, failed connections in the sewer system itself are important sources of human pathogens. We suggest treatment of stormwater run-offs before being discharged into the river system.
Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential
Authors: Mishra Sonali , Singh Shilpi , Ali Arif , Gupta Amit C. , Shanker Karuna , Bawankule Dnyaneshwar U. , Luqman Suaib 
Published: October 2019

Background:
Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and
their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid
(CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having
a number of therapeutic value.

Objective :
Microwave-assisted modifications in cinnamic acid were planned for potential anticancer
properties with better yield and efficiency. The present study also confirms the presence of HMB and
its precursor i.e. cinnamic acid in D. arayalpathra tubers.

Methods:
We used a single step Microwave Assisted Synthesis (MAS) to modify cinnamic acid, and
then examined the synthetic and natural cinnamic acid derivatives anticancer potential against six human
cancer (K-562, WRL-68, A549, A431, MCF-7, and COLO-201) and two normal (L-132 and
HEK-293) cell lines at 2, 10 and 50 µg/ml concentrations.

Results:
β-bromostyrene and β -nitrostyrene have shown inhibition with IC50 values ranging 0.10-21
µM and 0.03-0.06 µM, respectively to the cancer cell lines. β-bromostyrene was the most potent anticancer
derivative of CA with better cellular safety and biocompatibility.

Conclusions:
The present study of microwave-assisted synthesis demonstrates a single-step modification
in cinnamic acid. MAS is a fast, reliable, and robust method. The resultant compounds have
shown in-vitro anticancer activity against human lung carcinoma and breast adenocarcinoma.
Phosphatidylinositol 3-kinase Glu545Lys and His1047Tyr Mutations are not Associated with T2D
Authors: Elfaki Imadeldin , Mir Rashid , Abu-Duhier Faisel M. , Khan Roaid , Sakran Mohammed 
Published: October 2019

Background:
Insulin resistance initiated in peripheral tissues induces type 2 diabetes (T2D).
It occurs when insulin signaling is impaired.

Introduction:
Phosphatidylinositol 3-kinases (PI3K) are important for insulin signaling. Single nucleotide
polymorphisms of the PI3K gene have been associated with T2D.

Methods:
We have investigated the association of Glu545Lys and His1047Tyr mutations of phosphatidylinositol-
4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene with T2D. We have
screened 103 T2D patients and 132 controls for Glu545Lys mutation, and 101 T2D patients and 103
controls for the His1047Tyr mutation from a Saudi cohort using AS-PCR.

Results:
Our results indicated that there is no association between the GA genotype of rs104886003
(Glu545Lys) and T2D, OR= 0.15 (95% CI: 0.007-3.28), RR= 0.29(0.02-3.72), P value= 0.23. The A
allele is also not associated with T2D diabetes, OR= 1.01(95% CI: 0.70-1.46), RR=1.00(0.85-1.18), P
value=0.91. Results showed that CT genotype of rs121913281 (His1047Tyr) was not associated with
T2D, OR=0.94(95% CI: 0.23-3.9), RR= 0.97(0.48-1.97), P-value = 0.94, and T allele was also not associated
with T2D, OR=1.06 (95% CI: 0.71-1.56), RR= 1.02(0.84-1.24), P-value =0.76.

Conclusion:
We conclude that the A allele of rs104886003 may not be associated with T2D. The T allele
of rs121913281 may also not associated with T2D. However, future studies with larger sample
sizes and in different populations are recommended.
In silico Designing of Novel Inhibitors for Triple Inhibition of Aldose Reductase, Aldose Reductase Like Protein 1, and Aldehyde Reductase
Authors: Devi Arpita 
Published: October 2019

Background:
Cancer is a well-known and well-studied disease. There are environmental
as well as genetic factors that trigger cancer. All forms of cancer are associated with the deregulation
of genes and proteins. Aldose reductase, Aldose Reductase like protein 1 and Aldehyde Reductase
are homologous proteins that are overexpressed in different types of cancer. They are NADPHdependent
oxidoreductases. The active site is conserved, thus there is very less substrate specificity
among those proteins. In this study, novel molecules targeting the three proteins are designed.

Methods:
LigBuilder V2 software is used to design novel molecules. Molecular docking is performed
to study the binding affinity of each ligand towards the targets. Molecular Dynamics Simulation
was done to check the stability of protein-ligand complexes in an aqueous environment.

Results:
Six novel molecules have been designed. The six molecules studied are found to have better
in silico affinity than tolrestat (known inhibitor). The designed molecules are predicted to be orally
active. Finally, Molecular Dynamics Simulation showed that the protein-ligand complexes are stable
in an aqueous environment.

Conclusion:
New molecules targeting Aldose reductase, Aldose Reductase like protein 1 and Aldehyde
Reductase have been designed.
Interactions of Flavone and Steroid from A. subintegra as Potential Inhibitors for Porcine Pancreatic Lipase
Authors: Ibrahim Mastura , Abdul Azziz Saripah Salbiah Syed , Wong Chee Fah , Bakri Yuhanis Mhd , Abdullah Fauziah 
Published: October 2019

Background:
Obesity is one serious health condition that contributes to various chronic diseases.
The inhibition of pancreatic lipase is a promising treatment for obesity.

Objective:
The present study was designed to investigate anti-porcine pancreatic lipase effect of isolated
compounds from Aquilaria subintegra and its mechanism.

Methods:
Compounds were isolated with serial column chromatography and their structure were identified
using spectroscopic methods. Isolated compounds were tested for anti-lipase potential activity using
colorimetric assay. The prediction of energy binding between isolated compounds and enzyme was
described using YASARA software.

Results:
Four compounds were successfully isolated from the bark of A. subintegra, namely, 5-
hydroxy-7,4’-dimethoxyflavone, luteolin-7,3’,4’-trimethyl ether, 5,3’-dihydroxy-7,4’-dimethoxyflavone
and β-sitosterol. The results indicated that all compounds displayed promising pancreatic lipase
inhibitory activity ranging between of 6% to 53% inhibition. Compound 5-hydroxy-7,4’-
dimethoxyflavone was a competitive inhibitor and decreases the enzyme catalysis. Meanwhile, β-
sitosterol was a non- competitive inhibitor since the latter was bind allosterically toward enzyme.

Conclusion:
This finding is significant for further investigation of bioactive compounds from A. subintegra
on animal study.
Prospects of Wedelolactone as a Chemotherapeutic Agent in Gynecological Cancers; Clue From its In Vitro and In Silico Investigation
Authors: Sarwar Sadia , Amed Tauqeer , Qazi Neelum Gul , Yu Jun Qing , Huq Fazlul 
Published: October 2019

Background:Identification and development of new drug candidates to be used singly or in combination therapy is critical in anticancer research. In recent years, accumulating evidence encouraged us to investigate the anti-proliferative effects of a small and emerging phytochemical Wedelolactone (WDL) in estrogen-dependent and independent multiple gynecological tumor models.Objective:The aim of this study was to investigate the growth inhibitory effect of WDL on estrogen- dependent and independent gynecological cell lines and to explore its inhibitory potential towards key targets through in silico study.Methods:Cytotoxicity of WDL was investigated in human breast and ovarian cancer cell lines (MCF-7 and SKOV3) through 3-(4,5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) reduction assay. Epigallocatechingallate (EGCG) was used as reference natural compound while cisplatin was taken as a standard clinical agent. Both WDL and EGCG in combination with cisplatin were also evaluated for their combined growth inhibitory potential in MCF-7 cells. WDL was also evaluated in silico against key factors including braf kinases, CDPK, ERα, aromatase, topoisomerase II and dihydrofolate reductase (DHFR) playing pivotal roles in driving multiple tumors.Results and Discussion:The IC50 value of WDL was 25.77 ± 4.82 μM and 33.64 ± 1.45 μM in MCF-7 and SKOV-3 respectively. The binding energy order was as follows; WDL: DHFR >Braf kinases > CDPK; aromatase > topoisomerase II> ERα > NFkB > alkaline phosphatase; EGCG dihydrofolatereductase (DHFR) > aromatase >CDPK > topoisomerase II > braf kinases > alkaline phosphatase > CDPK > ERα > NFkB.Conclusion:We identified WDL as a cytotoxic agent in breast and ovarian tumor models with the potential to inhibit multiple targets in the oncogenic pathway including estrogen receptor ERα, as depicted through its in silico study. Based on our own research findings and from literature evidence, we conclude that further research should be encouraged to investigate different aspects of wedelolactone as an additional agent to be combined with antiestrogen/endocrine therapy.
Health-Related Social Control Influences the Physical Activity of College Students
Authors: Cotter Kelly A. , Mendiola Jennifer A. 
Published: October 2019

Objective:
To examine the impact of health-related social control tactics on the physical activity behavior of college students.

Participants:
110 undergraduates (74% women) recorded their naturalistic behavior across eight consecutive days between March and May of 2010.

Methods:
A short-term longitudinal daily diary survey examined daily self-reports of received health-related social control (the direct regulation of a target’s health behaviors by a social partner) and minutes engaged in physical activity.

Results:
Multilevel modeling according to a two-level structure in which observations (Level 1) were nested within individuals (Level 2) revealed that positive social control for exercise (e.g., encouragement) had a positive effect on physical activity participation, both within-persons (intra-individual level) and between-persons (inter-individual level). Negative social control (e.g., nagging) had no effect on physical activity participation.

Conclusion:
The present results suggest that individuals should employ positive social control tactics when attempting to enhance the physical activity behaviors of college students.