bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of health-related quality of life with epirubicin, cisplatin plus 5-fluorouracil and docetaxel, cisplatin plus 5-fluorouracil chemotherapy regimens as first-line systemic therapy in locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma: A prospective study from South India
Authors: Babu K. Govind , Chaudhuri Tamojit , Lakshmaiah K. C. , Dasappa Lokanatha , Jacob Linu Abraham , Suresh Babu M. C. , Rudresha A. H. , Lokesh K. N. , Rajeev L. K. 
Published: September 2019

Abstract
Background: Health-related quality of life (HRQOL) is an important oncologic end point for upper gastrointestinal malignancies. Unfortunately, till date, there is no published prospective data from India, comparing the HRQOL parameters between first-line chemotherapy regimens in advanced/metastatic gastric cancer. Materials and Methods: The present study aimed to compare the HRQOL of first-line systemic chemotherapy with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens in patients with locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma. The secondary end points were overall response rate, progression-free survival (PFS), overall survival (OS), and toxicity profile. Results: Between December 2014 and December 2016, 65 patients were treated with ECF (n= 34) or DCF (n= 31) regimen. The baseline HRQOL scores were comparable between the two study groups, with the exception of significantly poor pain and sleep difficulties symptom score in the DCF group. After three cycles of treatment, both the groups showed improvements in most of the quality of life (QOL) parameters including global QOL score, compared with their baseline status. After six cycles of chemotherapy, the ECF group showed nonsignificant deterioration for most of the QOL parameters; but on the contrary, the DCF group maintained improved scores for most of the QOL parameters. The median survival until a definitive deterioration of global QOL score was significantly better in the DCF arm in comparison to the ECF arm (7.1 vs. 5.6 months, respectively, P = 0.000). The median OS was 9.2 months with ECF and 12.5 months with DCF regimen (P = 0.000), while median PFS was 5.7 and 7.4 months with ECF and DCF regimens, respectively (P = 0.002). Conclusions: This prospective study highlighted a better impact of DCF chemotherapy on the HRQOL of patients with advanced/metastatic gastric cancer and showed the importance of QOL assessments in clinical trials to complement the risk–benefit judgment.
Small Intestinal Tumors
Authors: Sharma SM 
Published: September 2019

ABSTRACT
Small intestinal tumors are rare despite small gut being a long structure with extensive mucosal surface. The clinical presentation is vague and the existence of tumor is detected after specific investigations. Small gut can be benign or may be malignant. Malignant tumors present with abdominal pain, weight loss, anemia, obstructive features, abdominal lump, diarrhea, intussusception and even fever depending upon the type of lesion. Malignancy occurs generally in elderly group above 60 years; however, younger patients too may be affected. Benign lesions may remain asymptomatic for long till these cause complications like intussusception or obstruction. Early detection and appropriate intervention can avoid morbidity and mortality.

How to cite this article
Sharma SM. Small Intestinal Tumors. Int J Adv Integ Med Sci 2016;1(1):9-12.
Ovarian Ectopic Pregnancy: A Rare Case Report
Authors: Premi HK , Dahiya Sonika , Khan Shabina , Amrin Sana , Srivastava Sugandh 
Published: September 2019

ABSTRACT
Ovarian pregnancy is the most common type of non-tubal ectopic pregnancy. Ovarian ectopic pregnancy incidence after natural conception ranges from 1 in 2000 to 1 in 60,000 deliveries and accounts for 3% of all ectopic pregnancies. Here, we report a rare case of ruptured ectopic pregnancy. A 30 years old, G2P1+0L1 was admitted with amenorrhea of 1½ months and severe pain abdomen. Self urinary pregnancy test (UPT) was positive. Ultrasonography (USG) revealed it sided adnexal mass. Emergency laparotomy was done and a diagnosis of ovarian ectopic pregnancy was made.

How to cite this article
Dahiya S, Khan S, Premi HK, Amrin S, Srivastava S. Ovarian Ectopic Pregnancy: A Rare Case Report. Int J Adv Integ Med Sci 2016;1(1):23-24.
Effect of Nasal Packing on Middle Ear Pressure
Authors: Srivastava Abhinav , Shukla Puneet 
Published: September 2019

ABSTRACTIntroductionEustachian tube connects nasopharynx with the tympanic cavity. The normal middle ear has an inherent tendency to lose gas to maintain the middle ear pressure by diffusion into the surrounding tissues and circulation.Materials and methodsThis cross-sectional study was conducted in 2012 to 2014. A total of 100 ears of 50 consecutive cases undergoing nasal surgery followed by bilateral nasal packing were included in the study and the middle ear pressure and hearing threshold were determined in all the subjects in presurgery, and then after 48 hours of surgery with nasal packingin situand then at 7 and 30 days of nasal pack removal.ConclusionThere is an increase in middle ear pressure transiently for few days while the nasal pack isin situ, which returns to normal in a month after pack removal; but, in chronic nasal obstruction cases, such as nasal polyps, there is persistent negative middle ear pressure, probably due to irreversible changes in the Eustachian tube function.How to cite this articleMohan C, Srivastava A, Shukla P. Effect of Nasal Packing on Middle Ear Pressure. Int J Adv Integ Med Sci 2016;1(2):52-56.
Neurofibromatosis in Pregnancy
Authors: Premi HK , Dahiya Sonika , Mukherjee Shobha 
Published: September 2019

ABSTRACT
Neurofibromatosis (NF) is one of the most frequent genetic diseases in humans. It is less common to find pregnancy in NF patients. It may not reflect the real situation as most current information on pregnancy and NF is derived from case reports. In the past 15 years only two series of pregnant NF patients were reported in English language literature.
Neurofibromatosis is a genetic disorder which increases the risk of obstetric complications as well as aggravation of maternal disease. However, here is a case of NF in which transmission to baby has also occurred, which is very rare.

How to cite this article
Dahiya S, Mukherjee S, Premi HK. Neurofibromatosis in Pregnancy. Int J Adv Integ Med Sci 2016; 1(2):91-92.
Which Craft?: Witches, Gypsies, and the Fenyw Hysbys in Eighteenth-Century Wales
Authors: Tallis Lisa Mari 
Published: September 2019

ABSTRACT
Although marginal figures, Gypsies' significance in Welsh society and culture is often overlooked and despite their magical activities, in particular Gypsy women who were often believed to have the power to bewitch and read fortunes, they have been very much neglected within the historiography of witchcraft. So too have the activities of cunning-women, or the fenyw hysbys (wise-woman) as this figure was commonly termed in Wales, and so in an attempt to redress this imbalance, this article incorporates Welsh Romany-Gypsy women within the history of Welsh witchcraft. An examination of their magical activities and the beliefs surrounding them can also shed light on the activities of various cunning-women in Wales, about whom we know very little. This raises certain issues regarding “gender” and the “gendering of witchcraft” which will also be considered, thus bringing into question the benefits of applying such terms to the Welsh, and indeed other witchcraft models.
The Effect of Online Assessments on Students’ Attitudes Towards Undergraduate-Level Geography Courses
Authors: Sözen Erol , Güven Ufuk 
Published: September 2019

The improvements in technology made technology tools invade almost every field, including education. Online assessment tools have various functions for students and teachers. Students are able to use their mobile devices in the classroom, while teachers are able to use the tools for formative and summative evaluation purposes and for getting to know their students. Teachers also get feedback on their instructional practices by analyzing student responses.
Previous studies found that undergraduate students in Faculty of Education in Turkey do not have a very positive attitude for geography courses, because most of the students take geography courses almost every year until they enter the university. The aim of this study is to determine the effect of in-class online assessment tools on the attitudes of students at undergraduate level towards geography courses. In addition, the changes in students’ attitudes are examined for various variables. The study was designed in a quasi-experimental model with experiment and control groups. The study also implemented pre-tests and post-tests. Geography Attitude Scale developed by Sözen (2019) was used as data collection tool. The study’s sample consists of 70 students whose majors are Primary School Teacher in Faculty of Education. An online assessment tool was implemented for seven weeks in experiment group, while the control group did not receive the said tool. The study found that using online assessment tools significantly improved students’ attitude towards geography course.
Extraction as a Critical Step in Phytochemical Analysis
Authors: Mosić Mirjana , Dramićanin Aleksandra , Ristivojević Petar , Milojković-Opsenica Dušanka 
Published: September 2019

Abstract
Phytochemical analysis, the chemical investigation of plants, is a rapidly developing chemical discipline with various goals such as the determination of the substance classes and the isolation and qualitative and/or quantitative analyses of bioactive compounds or their structural analysis. The analysis of plants begins with optimizing extraction procedures because they play a key role in extraction outcomes, i.e., the isolation of bioactive compounds from natural products and the selection of the subsequent tests used in the analyses. The extraction is a critical step because it is necessary to extract the desired components of the complex natural matrix without destroying them. A wide range of techniques for the extraction of bioactive compounds from natural matrixes are currently available. This review aims to describe and compare the most commonly used methods, traditional/conventional and innovative/green. It will focus on the principles behind each method and on their strengths and limitations in order to help evaluate their suitability and economic feasibility, highlighting the advantages of new innovative techniques over conventional extraction procedures. Finally, the recent application of deep eutectic solvents as a new, eco-friendly method for the extraction of bioactive compounds from natural matrixes is also discussed.
Evaluation of Orchid-Like Aroma Between Different Grades of Taiping Houkui Tea by Solid-Phase Microextraction and Comprehensive Two-Dimensional Gas Chromatography Coupled with Time-of-Fight Mass Spectrometry
Authors: Qi Chen , Tianyang Guo , Qiong Wu , Jian Yao , Renyi Liao , Peng Wu , Shaotong Jiang , Yiyang Dong 
Published: September 2019

Abstract
Background: Taiping houkui tea won the title of “the King of Green Tea” at the International Tea Exposition in 2004, which had an orchid fragrance but the material basis of the orchid fragrance had not been revealed yet. Objective: To investigate the material basis of the orchid fragrance and identify the quality grade of Taiping houkui tea. Methods: A method was developed for evaluating orchid-like aroma between different grades Taiping houkui tea by solid-phase micro extraction (SPME) and comprehensive two-dimensional gas chromatography coupled with time-of-fight mass spectrometry (GC×GC-TOFMS). The crushed tea sample in a 25 mL headspace bottle was incubated at 90°C for 10 min. Then the gaseous sample was extracted by SPME divinylbenzene/polydimethylsiloxane fiber for 50 min and thermally desorpted at 250°C for 2 min. Results: In total, 735 volatile compounds were determined by SPME- GC×GC-TOFMS and 15 compounds were related to orchid-like aroma. Conclusions: The high-quality Taiping houkui tea has the orchid fragrance and the low-grade one does not; thus orchid-like aroma can be used as a reference of grades of Taiping houkui tea. Highlights: Thirty different grades of Taiping houkui tea samples were compared and analyzed experimentally, and the results showed that the special aroma substances, which played a key role in grade discrimination of Taiping houkui tea, were found by the statistical method.
Fine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland
Authors: Cantley Richard L. 
Published: September 2019

Context.—
Cellular basaloid neoplasms of the salivary gland represent a diverse group of benign and malignant neoplasms with significant cytomorphologic overlap on fine-needle aspiration cytology. All are marked by the presence of monotonous and usually bland basaloid epithelium. Distinction between basaloid neoplasms on fine-needle aspiration cytology is based on the presence or absence of additional features, including a second cell population (eg, myoepithelial cells), an acellular stromal component, and/or cytologic atypia within the basaloid epithelium. This review highlights the cytomorphologic features of the most common cellular basaloid neoplasms of the salivary gland, with an emphasis on classification and subclassification within the Milan System.

Objective.—
To provide a comprehensive review of the cytologic features of basaloid epithelial neoplasms of the salivary gland, with an emphasis on classification within the Milan System for Reporting Salivary Gland Cytopathology.

Data Sources.—
Peer-reviewed literature, recent textbooks, and personal experiences of the author.

Conclusions.—
Some basaloid neoplasms, in particular pleomorphic adenomas and adenoid cystic carcinomas, may have characteristic findings on fine-needle aspiration that allow for definitive diagnosis. In other cases, however, fine-needle aspiration can confirm a neoplastic basaloid process, but specific classification of a benign or malignant neoplasm cannot be rendered. The Milan System for Reporting Salivary Gland Cytopathology acknowledges this difficulty, and recommends benign or malignant classification only when definitive diagnostic features of a specific neoplasm are present. For indeterminate cases, the subcategorization of salivary neoplasm of uncertain malignant potential is recommended.
Pour ramener l’été
Authors: Arbour Chelsee , Ashini Napes , Jenkinson Anthony , Loring Stephen 
Published: September 2019

L’histoire des Innus dans la péninsule du Québec-Labrador remonte à au moins 8000 ans, comme en témoignent les « légendes » innues (atanukana) et l’archéologie. Même anémiées par les millénaires, les histoires qu’on nous raconte, comme Kautuasukuaniskuanast (histoire du petit garçon qui a ramené l’été et qui est devenu le Bruant à couronne blanche), sont des paraboles de l’histoire innue qui documentent l’arrivée des ancêtres innus à l’époque périglaciaire dans le Nitassinan. Les institutions coloniales se sont appropriées l’histoire récente. Elles présentent le passé (comme le présent et le futur) comme appartenant aux nouveaux arrivants français (mishtikushuat) et britanniques (akaneshauat). Les Innus sont totalement absents de cette histoire sauf comme figurants d’un tableau héroïque mettant en vedette d’intrépides « explorateurs » et aventuriers français et britanniques. L’archéologie peut contribuer à « ramener l’été » et peut-être permettre de raconter l’histoire innue non écrite en reconnaissant et en corrigeant le déséquilibre du pouvoir entre les versions occidentale et autochtone du passé.
POLÍTICAS DE DESARROLLO ECONÓMICO LOCAL. ¿Y SI REPENSAMOS LO BÁSICO?
Authors: Estela Barnet Oriol 
Published: September 2019

Resumen. Las políticas de desarrollo económico local han estado presentes en las agendas de los gobiernos locales españoles durante las tres últimas décadas, período en el cual ha habido que afrontar tres grandes crisis que han supuesto, en cada ocasión, la necesidad de incorporar nuevas perspectivas y nuevos instrumentos para la ejecución de dichas políticas. En particular, la crisis que estalla a finales de la primera década del siglo XXI pone de manifiesto las limitaciones del modelo de desarrollo económico local que se había generalizado hasta el momento: reactivo y dependiente de fondos finalistas de otras administraciones. Es en este momento cuando se hace evidente que el desarrollo económico local, para ser efectivo, sólo puede provenir de un enfoque de abajo arriba fundamentado en el convencimiento y la colaboración de los actores locales y poniendo en el centro las necesidades de las personas y el respeto por el entorno.

Palabras clave: Desarrollo económico local, Economía local, Estrategia, Necesidades humanas, Políticas públicas, Resiliencia, Sostenibilidad.

Abstract. Local economic development policies have been present in the agendas of the Spanish local governments during the last three decades, a period in which three major crises had taken place and had shown up the need to incorporate new perspectives and new instruments for the execution of these policies. In particular, the crisis that erupts at the end of the first decade of the 21st century highlights the limitations of the local economic development model that had been generalized up to now: reactive and dependent on finalist funds from other administrations. It is at this moment when it becomes clear that local economic development, to be effective, can only come from a bottom-up approach based on the conviction and collaboration of local actors and putting at the center the needs of people and the environment.

Key words: Local Economic Development, Local Economy, Strategy, Human Needs, Public Policy, Resilience, Sustainability.
Plant host and drought shape the root associated fungal microbiota in rice
Authors: Andreo-Jimenez Beatriz , Vandenkoornhuyse Philippe , Lê Van Amandine , Heutinck Arvid , Duhamel Marie , Kadam Niteen , Jagadish Krishna , Ruyter-Spira Carolien , Bouwmeester Harro 
Published: September 2019

Background and Aim
Water is an increasingly scarce resource while some crops, such as paddy rice, require large amounts of water to maintain grain production. A better understanding of rice drought adaptation and tolerance mechanisms could help to reduce this problem. There is evidence of a possible role of root-associated fungi in drought adaptation. Here, we analyzed the endospheric fungal microbiota composition in rice and its relation to plant genotype and drought.

Methods
Fifteen rice genotypes (Oryza sativa ssp. indica) were grown in the field, under well-watered conditions or exposed to a drought period during flowering. The effect of genotype and treatment on the root fungal microbiota composition was analyzed by 18S ribosomal DNA high throughput sequencing. Grain yield was determined after plant maturation.

Results
There was a host genotype effect on the fungal community composition. Drought altered the composition of the root-associated fungal community and increased fungal biodiversity. The majority of OTUs identified belonged to the Pezizomycotina subphylum and 37 of these significantly correlated with a higher plant yield under drought, one of them being assigned to Arthrinium phaeospermum.

Conclusion
This study shows that both plant genotype and drought affect the root-associated fungal community in rice and that some fungi correlate with improved drought tolerance. This work opens new opportunities for basic research on the understanding of how the host affects microbiota recruitment as well as the possible use of specific fungi to improve drought tolerance in rice.
Thermodinamical Analyse the Formation of Phosphates Copper, Zinc and Cobalt on the Base Double Superphosphate and Sulphates of Copper, Zinc and Cobalt
Authors: Turaev Z. , Shamshidinov I. T. , Usmanov I. I. , Isakova O. M. , Sultonov B. E. 
Published: September 2019

In this article the relationship between the entropies of crystalline calcium compounds and copper, zinc and cobalt compounds were analyzed. Thermal capacity dependence of temperature for acidic phosphates of copper, zinc and cobalt, determining value of enthalpy and entropy of copper, zinc and cobalt phosphates have been determined and the possibility to conduct thermodynamic analysis of reactions for their formation were established. Accordingly the data of thermodynamic analysis of temperature conditions for obtaining double superphosphate, the most formation of monosubstituted phosphates of copper, zinc and cobalt, and possibility of formation disubstituted of copper phosphates.
Can Histochemical c-mpl Positivity in Bone Marrow be a Predictor for Splenectomy in Immune Thrombocytopenia?
Authors: Yavasoglu Irfan , Gencer Nadide , Cantas Fulden , Doger Firuzan , Bolaman Zahit 
Published: September 2019

Purpose: Splenectomy is used as the second line therapy in patients with immune thrombocytopenia (ITP). However, there is no parameter predicting splenectomy decision. Thrombopoietin is the main regulator of platelet count through its receptor c-mpl. The aim of the present study was to evaluate immune histochemical Cloned Myeloid Leukemia Virus (c-mpl) positivity in bone marrow specimens of ITP patients with or without splenectomy indications.
Methods: Pre-splenectomy bone marrow was stained for c-mpl, that was taken from 24 patients with ITP and who had splenectomy as well as bone marrow samples from 30 patients with ITP who did not have splenectomy.
Results: c-mpl negativity was higher in splenectomized patients (n: 23) compared to patients without splenectomy (n:18). A significant difference was found for platelet counts before and after splenectomy. Our study show that, c-mpl positivity was statistically significant in patient group who did not have splenectomy. In the patient group who had the splenectomy, c-mpl was not associated with refractory status.
Conclusion: The significant level of c-mpl negativity might be the useful parameter for splenectomy indication in patients with immune thrombocytopenia.
Collection, Transport, and Manipulation of Clinical Specimens and Other Preanalytical Concerns
Authors: Linscott Andrea J. , Wang Huanyu 
Published: December 2024

Abstract
The collection, transport, and processing of clinical specimens are preanalytical steps that are key to organism recovery. Quality specimens must be collected in order to provide the most clinically relevant microbiology results for the patients. Collection of a specimen is dependent on the anatomic site of infection or suspected disease. Certain specimens—such as blood specimens for blood cultures; skin, hair, and nails for fungal culture; and CSF samples, unless for viral cultures—for bacterial cultures should never be refrigerated. Common collection devices used for microbiologic specimens include sterile urine cups or urine transport tubes with preservatives, sterile wide‐mouth containers, agar plates that have been directly inoculated, sterile screw‐cap tubes, blood culture bottles or lysis centrifugation tubes, and swabs submitted in a transport medium. Triaging specimens for processing may become necessary when large volumes of specimens are received at the same time.