bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiopaque Fully Degradable Nanocomposites for Coronary Stents
Authors: Ang Hui Ying , Toong Daniel , Chow Wei Shoon , Seisilya Welly , Wu Wei , Wong Philip , Venkatraman Subbu S. , Foin Nicolas , Huang Yingying 
Published: November 2018

AbstractBioresorbable scaffolds (BRS) were introduced to overcome limitations of current metallic drug-eluting stents and poly-L-lactide (PLLA) has been used in the fabrication of BRS due to its biodegradability and biocompatibility. However, such polymers have weaker mechanical properties as compared to metals, limiting their use in BRS. We hypothesized that nanofillers can be used to enhance the mechanical properties considerably in PLLA. To this end, polymer-matrix composites consisting of PLLA reinforced with 5–20 wt% barium sulfate (BaSO4) nanofillers as a potential BRS material was evaluated. Stearic-acid (SA) modified BaSO4 nanofillers were used to examine the effect of functionalization. Rigid nanofillers improved the tensile modulus and strength of PLLA (60% and 110% respectively), while the use of SA-BaSO4 caused a significant increase (~110%) in the elongation at break. Enhancement in mechanical properties is attributed to functionalization which decreased the agglomeration of the nanofillers and improved dispersion. The nanocomposites were also radiopaque. Finite element analysis (FEA) showed that scaffold fabricated from the novel nanocomposite material has improved scaffolding ability, specifically that the strut thickness could be decreased compared to the conventional PLLA scaffold. In conclusion, BaSO4/PLLA-based nanocomposites could potentially be used as materials for BRS with improved mechanical and radiopaque properties.
Low Temperature Bonding by Infiltrating Sn3.5Ag Solder into Porous Ag Sheet for High Temperature Die Attachment in Power Device Packaging
Authors: Hang Chunjin , He Junjian , Zhang Zhihao , Chen Hongtao , Li Mingyu 
Published: November 2018

AbstractWe have proposed a high temperature die attach method with porous Ag sheet as an interlayer for power device packaging. Sn-3.5Ag solder paste can infiltrate into the porous Ag sheet through capillary forces and Sn can react with the porous Ag sheet and Ag metallizations at the interfaces to form Ag3Sn after reflow at 260 °C for 10 min. The large specific surface area and the high diffusion rates between Ag and Sn accelerate the Sn consumption in the porous Ag structure, thus significantly reducing the processing time. The difference of the melting points of the die attach material before and after reflow could be expanded as large as 259 °C. The bondlines show good electrical and thermal conductivities. Furthermore, the average shear strength of the bondlines at 300 °C is higher than 20 MPa. The porous Ag skeleton remained in the bondline would contribute greatly to the heat dissipation and the electrical signal transmission in power devices.
Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages
Authors: Gong Guowei , Wang Huaiyou , Kong Xiangpeng , Duan Ran , Dong Tina T. X. , Tsim Karl W. K. 
Published: November 2018

AbstractScutellariae Radix (SR), also named Huangqin in China, is the dried root of Scutellaria baicalensis Georgi. Historically, the usage of SR was targeted to against inflammation. In fact, chronic inflammation has a close relationship with hypoxia and abnormal angiogenesis in tumor cells. Hence, we would like to probe the water extract of SR in suppressing the inflammation-induced angiogenesis. Prior to determine the pharmaceutical values of SR, the first step is to analysis the chemical compositions of SR according to China Pharmacopeia (2015). From the results, the amount of baicalin was 12.6% by weight. Furthermore, the anti-angiogenic properties of SR water extract were evaluated in lipopolysaccharide (LPS) pre-treated cultured macrophage RAW 264.7 cells by detecting the inflammatory markers, i.e. Cox-2, cytokine and iNOS, as well as the translocation activity of NFκB and angiogenic biomarker, i.e. VEGF. This herbal extract was capable of declining both inflammatory and angiogenic hallmarks in a concentration-dependent manner. Moreover, the SR-derived flavonoids, i.e. baicalin, baicalein, wogonin and wogonoside, were shown to be active chemicals in the anti-inflammatory-induced angiogenesis. Therefore, the inflammation-induced angiogenesis is believed to be suppressed by SR water extract, or its major ingredients. These results shed light in the benefiting role of SR in the inflammation-induced angiogenesis in vitro.
A prostate derived commensal Staphylococcus epidermidis strain prevents and ameliorates induction of chronic prostatitis by UPEC infection
Authors: Murphy Stephen F. , Hall Christel , Done Joseph D. , Schaeffer Anthony J. , Thumbikat Praveen 
Published: November 2018

AbstractChronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common syndrome with limited therapies and an unknown etiology. Previously, our laboratory has defined a potential role for pathogenic infection in disease onset. Intra-urethral infection with a uropathogenic Escherichia coli strain isolated from a CP/CPPS patient, CP1, induces prostatic inflammation and tactile allodynia in mice. We have also demonstrated that a prostate specific Staphylococcus epidermidis bacterial isolate, NPI (non-pain inducing), from a healthy subject reduces pain and inflammation in an experimental autoimmune prostatitis (EAP) murine model. Here we focus on the interplay between these human isolates in the context of prostatitis development and resolution. NOD/ShiLtJ mice were inoculated with either NP1 or CP1, or combinations of both. Infection with CP1 induced pelvic tactile allodynia after 7 days, while NPI instillation alone induced no such response. Instillation with NPI 7 days following CP1 infection resolved pelvic tactile allodynia and prophylactic instillation 7 days prior to CPI infection prevented its onset. Prophylactic NPI instillation also prevented CP1 colonization of both prostate and bladder tissues. In vitro analyses revealed that CP1 and NPI do not directly inhibit the growth or invasive potential of one another. Immunological analyses revealed that specific markers associated with CP1-induced pelvic allodynia were decreased upon NPI treatment or repressed by prophylactic colonization. This study demonstrates that a commensal bacterial isolate can inhibit the colonization, pain responses, and immunological activation to uropathogenic bacteria, emphasizing the power of a healthy prostatic microflora in controlling health and disease.
Retraction notice to: “Adaptive algorithm for wireless data transmission (including images) based on SISO system and OFDM technique”
Authors: Fedosov Valentin , Legin Andrey , Lomakina Anna 
Published: November 2018

At the request of the Authors, the following article has been retracted from MATEC Web of Conferences Volume 226 for the following reason: This article was sent simultaneously by mistake to two different journals, MATEC Web of Conferences and another journal, generating an ethical problem of double publication. The organizers and the authors apologize for the mistake that is more related to an administrative error than a deliberate misconduct. The Editorial Board of MATEC Web of Conferences and EDP Sciences have agreed to retract the article.
Refers to RETRACTED: Adaptive algorithm for wireless data transmission (including images) based on SISO system and OFDM technique, Valentin Fedosov, Andrey Legin and Anna Lomakina, published online on 07 November 2018
Zur Frage der klinischen Signifikanz in deutschen rehabilitationswissenschaftlichen Interventionsstudien – eine Bestandsaufnahme der gängigen Praxis
Authors: Höder Jürgen , Hüppe Angelika 
Published: November 2018

Zusammenfassung
Ziel Es wird untersucht, ob und wie „klinische Signifikanz“ in deutschen rehabilitationswissenschaftlichen Interventionsstudien behandelt wird.
Methode Analyse von 64 zwischen 2012 und 2016 publizierten Studien, die Daten zu mindestens 2 Messzeitpunkten berichteten und an denen deutsche Wissenschaftler und Rehaeinrichtungen beteiligt waren.
Ergebnisse In 28% der Studien wird klinische Signifikanz erwähnt, 19% definieren, was sie darunter verstehen, 13% begründen die Definition. 70% berichten Maßzahlen, die etwas über klinische Signifikanz aussagen könnten, aber nur 28% nutzen die Zahlen tatsächlich dafür. Die am häufigsten verwendeten Statistiken sind Effektstärkemaße (45%). Sie werden ohne weitere Reflexion schematisch im Sinne der Cohen‘schen Kategorien interpretiert.
Fazit Die klinische Relevanz der Befunde zu bestimmen und zu diskutieren, findet sich in der Mehrzahl der Studien nur in Ansätzen oder gar nicht.
Die bewährte Indikation in der Zahnheilkunde
Authors: Schule Roland 
Published: November 2018

ZusammenfassungGrundsätzlich bestehen der Wunsch und der therapeutische Wille, bei akuten Erkrankungen eine rasche und zielführende Arzneimittelauswahl zu treffen, ohne in jedem einzelnen Krankheitsfall das komplette Programm für die Behandlung von akuten Krankheiten zu bemühen. Was nach der Erfahrung im Umgang mit Epidemien erkannt wurde und in der Ausführung im „Organon“ studiert werden kann, lässt sich auch auf wiederkehrende und akute Beschwerden in der Zahnheilkunde übertragen. Ein großes Patientenklientel mit gleichlautender Diagnose und damit verbunden einer vereinheitlichten Symptomatik erlaubt die Zuordnung zu einer „bewährten Indikation“. Das Spektrum für den Notfallbereich innerhalb der Zahnmedizin deckt Entzündungen, Verletzungen, vielschichtige Schmerzzustände und psychisch-vegetative Belastungen ab. Für den erfahrenen Kliniker bedeutet diese Sonderform der homöopathischen Verordnung eine große Hilfestellung im Praxisalltag. Sie erlaubt rasche Sofortmaßnahmen im Rahmen der Ersten Hilfe und schafft Raum für weitere, tiefgreifende Fallaufnahme und Arzneimittelbestimmung. Alleine für sich betrachtet erfüllt die „bewährte Indikation“ nie das individualisierende Krankheitsverständnis im Rahmen der klassischen Homöopathie. Die therapeutische Kunst besteht in der richtigen Wahl zur richtigen Zeit.
Ein vermuteter Schlangenbiss und die Irrwege der Medikamentenwahl
Authors: Trebin Ernst 
Published: November 2018

ZusammenfassungDie Fallbeschreibung verdeutlicht den manchmal komplizierten Weg der Mittelsuche und die bei der jeweiligen Verdachtsdiagnose indizierten Arzneien bis hin zur Mittelwahl Ledum.
Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells
Authors: Dittharot Kanthanadon , Dakeng Sumana , Suebsakwong Parichat , Suksamrarn Apichart , Patmasiriwat Pimpicha , Promkan Moltira 
Published: November 2018

AbstractBreast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis. Cucurbitacin B has antiproliferative activity against various human breast cancer cells, but the molecular mechanism is not completely understood. In this study, we explore the influence of cucurbitacin B from Trichosanthes cucumerina on the methylation status at the promoter of oncogenes c-Myc, cyclin D1, and survivin in breast cancer cell lines. Growth inhibitory effect of cucurbitacin B on breast cancer cells was assessed by MTT assay and colony formation assay. Methylation status of genomic DNA was determined by methylation-specific PCR. Gene and protein expression levels of all genes studied were analyzed by real-time RT-PCR and western blot. The results indicated that cucurbitacin B could inhibit cell growth in breast cancer cells. The oncogene promoters are usually hypomethylated in cancer cells. Upon cucurbitacin B treatment, upregulation of DNMT1 and obvious heavy methylation in the promoters of c-Myc, cyclin D1, and survivin, which consequently downregulated the expression of all these oncogenes, were observed. Hence, cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the oncogenic activation.
In Vivo Biocompatibility of a Novel Expanded Polytetrafluoroethylene Suture for Annuloplasty
Authors: Dudenhöffer Daniel W. , Laschke Matthias W. , Giebels Christian , Karliova Irem , Schneider Ulrich , Menger Michael D. , Schäfers Hans-Joachim 
Published: November 2018

AbstractBackground Expanded polytetrafluoroethylene (ePTFE) is a suture material for annuloplasty in aortic valve repair. For this particular application, it should induce minimal local stress and promote rapid tissue incorporation. To achieve this, a novel ePTFE suture with a larger diameter and high porosity in its midsection has been developed. Herein, we analyzed the acute and chronic tissue reaction to this suture material compared with a commercially available control ePTFE suture.Methods Novel and control suture samples were implanted into dorsal skinfold chambers of BALB/c mice to analyze the early inflammatory response using intravital fluorescence microscopy over 14 days. Additional suture samples were implanted for 4 and 12 weeks in the flank musculature of mice and analyzed by histology and immunohistochemistry.Results The implantation of novel and control ePTFE suture into the dorsal skinfold chamber did not induce an acute inflammation, as indicated by physiological numbers of rolling and adherent leukocytes in all analyzed venules. Chronic implantation into the flank musculature showed a better tissue incorporation of the novel ePTFE suture with more infiltrating cells and a higher content of Sirius red+ collagen fibers when compared with controls. Cell proliferation and viability as well as numbers of recruited CD68+ macrophages, myeloperoxidase+ neutrophilic granulocytes and CD3+ lymphocytes did not significantly differ between the groups.Conclusion The novel ePTFE suture exhibits a good in vivo biocompatibility which is comparable to that of the control suture. Due to its improved tissue incorporation, it may provide a better long-term stability during annuloplasty.
Implementation of a Standardized Patient Safety Checklist in Ophthalmic Surgery
Authors: Boese Erin , Lee Paul , Greenberg Grant , Harrison Richard , Weizer Jennifer 
Published: November 2018

Objective To develop and institute a standardized ophthalmology-specific operating room checklist, and to test adherence to the surgical checklist components after implementation.
Design An ophthalmology-specific operative room checklist was developed using recommendations from surgical preoperative checklists from other subspecialties and checklists specific to cataract surgery. This standardized checklist was then implemented into the operating rooms. Operative room staff was trained on its use. Adherence to the checklist was measured prospectively.
Setting Surgical centers at Kellogg Eye Center in Ann Arbor and Livonia, Michigan.
Participants Patients undergoing ophthalmic surgery at the Livonia and Ann Arbor surgical centers.
Main Outcome(s) and Measure(s) The primary outcome measures were surgical team adherence to each category of the operative checklist (preop, prebrief, preanesthesia verification, time-out, intraocular lens measurement/confirmation for cataract cases, debrief). Adherence to the subsections of the operative checklist was measured during three periods over the course of 1 year: baseline, postintervention (after introduction of the checklist in all operating rooms), and postadjustment (after additional training was provided to operating room staff and incentives to collect data were provided to personnel responsible for collecting it).
Results A total of 2,532 surgical cases were included in the analysis. Baseline adherence ranged from 87 to 90% across preop, prebrief, preanesthesia, and time-out verification sections of the operative checklist. After the institution of the intervention and adjustments, adherence to the surgical checklist improved significantly across all areas of the checklist to 97–98% (p < 0.01).
Conclusions and Relevance The development and implementation of an ophthalmology-specific operative room checklist increase adherence to recommended safety checks prior to the start of surgery. To maximize patient safety, the same or similar checklist is recommended for use in all ophthalmology operating rooms.
The calculation of transcript flux ratios reveals single regulatory mechanisms capable of activation and repression
Authors: Galburt Eric A. 
Published: November 2018

Significance
Cells adapt to their environment by modulating the amount of RNA transcripts produced in a gene-specific manner. While some transcription factors are recruited via DNA sequence motifs, other factors bind directly to RNA polymerase to modulate the rate constants underlying the initiation process. Here, I describe a freely available web-based tool to quantitatively evaluate how factor-induced changes in the rate constants connecting initiation intermediates combine to regulate the amount of RNA produced per time. I use these calculations to show that multifaceted kinetic mechanisms may lead to differential and promoter-specific regulation. Finally, I explore the mechanisms of two factors essential for the response of bacteria to stress. The insights provided help to understand the logic of bacterial gene regulation.
Jump rope vortex in liquid metal convection
Authors: Vogt Tobias , Horn Susanne , Grannan Alexander M. , Aurnou Jonathan M. 
Published: November 2018

Significance
The large-scale circulation (LSC) is the key dynamical feature of turbulent thermal convection. It is the underlying structure that shapes the appearance of geo- and astrophysical systems, such as the solar granulation or cloud streets, and the cornerstone of theoretical models. Our laboratory-numerical experiments reveal that the LSC can perform a fully 3D motion resembling a twirling jump rope. The discovery of this LSC mode implies that the currently accepted paradigm of a quasi-planar oscillating LSC needs to be augmented. Moreover, it provides an important link between studies in confined geometries used in experiments and simulations and the effectively unconfined fluid layers in natural settings where an agglomeration of LSCs forms larger patterns.
RT States: systematic annotation of the human genome using cell type-specific replication timing programs
Authors: Poulet Axel , Li Ben , Dubos Tristan , Rivera-Mulia Juan Carlos , Gilbert David M , Qin Zhaohui S 
Published: November 2018

Abstract

Motivation
The replication timing (RT) program has been linked to many key biological processes including cell fate commitment, 3D chromatin organization and transcription regulation. Significant technology progress now allows to characterize the RT program in the entire human genome in a high-throughput and high-resolution fashion. These experiments suggest that RT changes dynamically during development in coordination with gene activity. Since RT is such a fundamental biological process, we believe that an effective quantitative profile of the local RT program from a diverse set of cell types in various developmental stages and lineages can provide crucial biological insights for a genomic locus.

Results
In this study, we explored recurrent and spatially coherent combinatorial profiles from 42 RT programs collected from multiple lineages at diverse differentiation states. We found that a Hidden Markov Model with 15 hidden states provide a good model to describe these genome-wide RT profiling data. Each of the hidden state represents a unique combination of RT profiles across different cell types which we refer to as ‘RT states’. To understand the biological properties of these RT states, we inspected their relationship with chromatin states, gene expression, functional annotation and 3D chromosomal organization. We found that the newly defined RT states possess interesting genome-wide functional properties that add complementary information to the existing annotation of the human genome.

Availability and implementation
R scripts for inferring HMM models and Perl scripts for further analysis are available https://github.com/PouletAxel/script_HMM_Replication_timing.

Supplementary information
Supplementary data are available at Bioinformatics online.
Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys
Authors: Qi Hui-Xin , Liao Chia-Chi , Reed Jamie L , Kaas Jon H 
Published: November 2018

Abstract
Unilateral dorsal column lesions (DCL) at the cervical spinal cord deprive the hand regions of somatosensory cortex of tactile activation. However, considerable cortical reactivation occurs over weeks to months of recovery. While most studies focused on the reactivation of primary somatosensory area 3b, here, for the first time, we address how the higher-order somatosensory cortex reactivates in the same monkeys after DCL that vary across cases in completeness, post-lesion recovery times, and types of treatments. We recorded neural responses to tactile stimulation in areas 3a, 3b, 1, secondary somatosensory cortex (S2), parietal ventral (PV), and occasionally areas 2/5. Our analysis emphasized comparisons of the responsiveness, somatotopy, and receptive field size between areas 3b, 1, and S2/PV across DCL conditions and recovery times. The results indicate that the extents of the reactivation in higher-order somatosensory areas 1 and S2/PV closely reflect the reactivation in primary somatosensory cortex. Responses in higher-order areas S2 and PV can be stronger than those in area 3b, thus suggesting converging or alternative sources of inputs. The results also provide evidence that both primary and higher-order fields are effectively activated after long recovery times as well as after behavioral and electrocutaneous stimulation interventions.
A subcutaneous fluid collection after the Bentall procedure in a female patient with giant cell arteritis
Authors: Guimaron Samantha , Heautot Jean-François , Cador-Rousseau Bérangère , Verhoye Jean-Philippe 
Published: November 2018

Abstract
We report a 61-year-old woman with a history of untreated inflammatory symptoms, who underwent a Bentall procedure for a rapidly evolving aneurysm. Postoperatively, she presented with a sub-sternal pulsatile mass communicating with a periaortic collection. After excluding surgical and infectious complications, an inflammatory seroma due to an uncontrolled vasculitis was suspected. We proposed a non-surgical approach involving immunosuppressive therapy.
Obstinate nature
Authors: Cury Philippe 
Published: November 2018

Abstract
Resolving ecological patterns is challenging but fascinating as it generates new ways of looking at nature. I recapitulate here four independent scientific ideas that I developed throughout my career and that have contributed to a better understanding of the functioning of marine ecosystems. The optimal environmental window relating wind intensity and fish recruitment, the extended homing strategy developing an ecology of individuals, the wasp-waist control of marine ecosystems, and the bird-forage fish interaction are the four patterns that are presented. Communicating results to a large audience is not simply an added value of a scientific career but a responsibility for scientists when considering global emerging challenges. I encourage young scientists to communicate in an open and organized manner, as it will contribute to changing stakeholder’s views and fisheries management. Love of science and ground-breaking ideas are key to scientific careers and creativity can be sustained in many ways throughout a scientist’s career. I provide several tricks inspired by my personal experience that can help young scientists to stay innovative in the long run. Finally, I combine ecology and music, my two favourite topics, illustrating that an obstinate nature and an unexpected combination of unrelated ideas are key when dealing with research.