bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of the ATPase Domain of Human Topoisomerase IIa on HepG2 Cells by 1, 2-benzenedicarboxylic Acid, Mono (2-ethylhexyl) Ester: Molecular Docking and Dynamics Simulations
Authors: Selvakumar Jemimah Naine , Chandrasekaran Subathra Devi , Doss George Priya C. , Kumar Thirumal D. 
Published: November 2018

Background:
The major attention has been received by the natural products in the
prevention of diseases due to their pharmacological role.

Objective:
The major focus of the study was to search for highly potential anti-cancer compounds
from marine Streptomyces sp. VITJS4 (NCIM No. 5574).

Methods:
Cytotoxic assay was examined by MTT assay on HepG2 cells. Bioassay-guided fractionation
of the ethyl acetate extract from the fermented broth led to the isolation of the compound. The
lead compound structure was elucidated by combined NMR and MS analysis, and the absolute configuration
was assigned by extensive spectroscopic analysis.

Results:
On the basis of spectroscopic data, the compound was identified as 1, 2
benzenedicarboxylic acid, mono 2-ethylhexyl (BMEH). The compound exhibited in vitro anticancer
potential against liver (HepG2) cancer cells. Based on the flow cytometric analysis, it was evident
that the BMEH was also effective in arresting the cell cycle at G1 phase. Further, the Western blotting
analysis confirmed the down-regulation of Bcl-2 family proteins, and activation of caspase-9
and 3. The molecular docking and dynamics simulation were performed to reveal the activity of the
compound over a time period of 10ns. From the molecular dynamics studies, it was found that the
stability and compactness were attained by the protein by means of the compound interaction.

Conclusion:
This study highlights our collaborative efforts to ascertain lead molecules from marine
actinomycete. This is the first and foremost report to prove the mechanistic studies of the purified
compound 1, 2-benzene dicarboxylic acid, mono(2-ethylhexyl) ester isolated from marine Streptomyces
sp.VITJS4 against HepG2 cells.
Synthesis of Benzo[d]imidazo[2,1-b]thiazole-Propenone Conjugates as Cytotoxic and Apoptotic Inducing Agents
Authors: Shaik Siddiq P. , Reddy Telukutta S. , Sunkari Satish , Rao Ayinampudi V.S. , Babu Korrapati S. , Bhargava Suresh K. , Kamal Ahmed 
Published: November 2018

Background:
Cancer can be considered as a disease in which normal cells start behaving badly,
multiplying uncontrollably, ignoring signals to stop and accumulating to form a mass that is generally termed as
a tumor. Apoptosis or programmed cell death is a physiological process that enables organisms to control their
cell numbers in many developmental and physiological settings and to eliminate unwanted cells and it plays
essential role in chemotherapy-induced tumor-cell killing. The correct balance between apoptosis and inhibition
of apoptosis is important in animal development as well as in tissue homeostasis. The aim of this paper is to
introduce the readers about the design strategy and synthesis of effective cytotoxic and apoptotic inducing
agents based on benzo[d]imidazo[2,1-b]thiazole scaffold.

Methods:
Benzo[d]imidazo[2,1-b]thiazole-propenone conjugates were synthesized by the condensation of 7-
methoxy-2-(aryl)benzo[d]imidazo[2,1-b]thiazol-3-yl)prop-2-yn-1-ones with aryl/hetero aryl amines in ethanol at
room temperature. These in turn were obtained from 7-methoxy-2-(aryl)benzo[d]imidazo[2,1-b]thiazole-3-
carbaldehydes on treatment with ethynylmagnesium bromide followed by oxidation.

Results:
3-Arylaminopropenone linked 2-arylbenzo[d]imidazo[2,1-b]thiazole conjugates prepared in this investigation
exhibited significant cytotoxic activity and arrested HeLa cancer cells in G1 phase. The treatment of the
conjugate led to 40% of loss of mitochondrial membrane potential (DΨm) in HeLa cells and 4 fold increase in
the levels of reactive oxygen species (ROS). In addition, it induces apoptosis in HeLa cells, this was examined
by the wound healing assay, Actin filaments and Hoechst staining assay.

Conclusion:
The encouraging biological profile exhibited by these 3-arylaminopropenone 2-aryl linked
benzo[d]imidazo[2,1-b]thiazole conjugates demonstrate that they have the potential to be developed as a lead by
further structural modifications to obtain potential chemotherapeutic agents that are likely to target the HeLa
cancer cells.
Método y estudio del Gobierno Electrónico municipal. Una propuesta metodológica y su aplicación al gobierno municipal en Galicia
Authors: Canoura Leira Victoria 
Published: November 2018

<p>Los distintos niveles gubernamentales están avanzando en la consecución del Gobierno Electrónico, incorporando las TIC en su gestión interna y en su relación con la ciudadanía, siendo los portales web la vía principalmente utilizada en dicha relación. Con el propósito de adaptar los métodos de estudio existentes y conocer el desarrollo del Gobierno Electrónico en el nivel municipal en la Comunidad Autónoma de Galicia (España), se ha realizado un estudio en el que se aplican una serie de test heurísticos y un experimento de usuario misterioso, que permite averiguar la calidad de la comunicación de los gobiernos municipales a través de los canales <em>on line</em> puestos a disposición de la ciudadanía. Tras el análisis, podemos concluir que existen en los recursos web analizados, elementos propios del Gobierno Electrónico; pero su grado de desarrollo es dispar en las distintas unidades que se han estudiado y la visión general nos lleva a afirmar que el estado del Gobierno Electrónico en el contexto municipal en Galicia está poco avanzado. </p>
Programas de desemprego programado
Authors: Marzochí Ilana 
Published: November 2018

Partindo de uma reflexão sobre o declínio do modelo tradicional da casa/família e paulatina substituição pela empresa, analiso os jogos programados televisivos cujo modo de funcionamento remete diretamente à dinâmica seletiva das grandes companhias: intensa competitividade;perpetuação do estado de mobilização, motivação, tensão, jovialidade,hiperatividade e risco sempre presente de ser excluído ("desempregado"), tudo sob vigilância e controle exacerbados. Ao vender modos de ser e maneiras de agir, essas práticas de grupos voltadas para a máxima performance do indivíduo minam qualquer possibilidade de laços afetivos e projetos duradouros em um clima de acirrada competitividade, curto
prazo e desemprego.
Das redes de pesca às redes da imaginação criadora - Novos elementos para uma epistemologia da comunicação
Authors: Paiva Cláudio 
Published: November 2018

No texto buscou-se pensar a "cultura das redes" como uma metáfora pertinente para traduzir o sentido das experiências de sociabilidade e comunicabilidade no contexto brasileiro, cujos tempos de trabalho e de lazer estão profundamente ligados a uma semântica e uma pragmática das "redes". No contexto da aceleração tecnológica do século XXI, os recentes processos multimidiáticos (abrangendo as mídias analógicas e digitais)
configuram uma experiência cultural híbrida em que as formas pré-industriais e pós-modernas se encontram (e se confrontam). A idéia é pensar uma epistemologia dialógica e sensível que possa dar conta dessa complexidade cultural.
O Pioneirismo de Danton Jobim na Pesquisa Jornalística Brasileira
Authors: Marques de Melo José 
Published: November 2018

Danton Jobim foi o jornalista que atuou como artífice da pesquisa comunicacional na região Sudeste Brasileiro. Ele foi responsável pelos estudos seminais do jornalismo na universidade brasileira, liderando a equipe docente do Curso de Jornalismo da Universidade do Brasil, hoje denominada Universidade Federal do Rio de Janeiro. Para melhor
compreensão do seu protagonismo, o trabalho resgata o multifacetado itinerário que ele percorreu na imprensa, na academia e na política.
O que a história pode legar aos estudos de jornalismo
Authors: Barbosa Marialva 
Published: November 2018

O texto procura mostrar a importância da adoção dos postulados fundamentais da teoria da história para os estudos de jornalismo. Considerando cinco postulados fundamentais da teoria da história - a interpretação, a narrativa, o conhecimento como episthéme, a questão do
tempo e do espaço - destaca-se como esta aproximação pode enriquecer as teorias em torno da notícia.
Donnie Darko: Imagem, Tecnologias Digitais e Multimediação em um Filme entre o Underground e o Massivo
Authors: Felinto Erick 
Published: November 2018

A experiência cultural contemporânea parece recusar a possibilidade dos desenhos nítidos e das definições acabadas. Oposições tradicionais como erudito ou massivo e comercial ou experimental perdem sua consistência e dão lugar a uma poética da imprecisão, do hibridismo e da ruptura de fronteiras. O obscuro Donnie Darko (2001), filme de estreia do diretor Richard Kelly, oferece excelente campo para a exploração dessa poética híbrida, dado que trabalha tais ambiguidades em uma multiplicidade de níveis, desde sua indefinição em termos de gênero (ficção científica, drama adolescente, terror, ficção historiográfica, etc) até sua hesitação quanto à natureza cultural (cinema experimental, paradigma hollywoodiano). O objetivo deste trabalho é investigar os desdobramentos da poética da imprecisão em um filme de relativo sucesso comercial, explorando especialmente o papel das tecnologias digitais na configuração de um território híbrido e multimidiático, que envolve não apenas o filme em si, mas também os produtos que complementam sua narrativa, como seu
website oficial, salas de discussão e extras do DVD.
Características do jornalismo impresso local e suas interfaces com jornais comunitários
Authors: Dorneles Beatriz 
Published: November 2018

Este trabalho objetiva complementar artigo de autoria de Cicília Krohling Peruzzo, intitulado "Mídia local e suas interfaces com a mídia comunitária", publicado no Anuário UnescolUmesp de Comunicação Regional, Ano 6, N° 6, jan-dez 2002. Pretendemos dirigir o enfoque para características relativas especificamente ao jornalismo impresso, de maneira a contribuir com a sustentação teórica de pesquisas que vêm sendo realizadas em torno de jornais com ênfase no local, regional ou dirigidos a comunidades especificas. Observou-se que algumas características apresentadas para a mídia como um todo não são apropriadas para o estudo da imprensa local, bem como existem outras, próprias a este segmento, juntamente com especificidades relativas aos conteúdos e práticas, não abordadas por Peruzzo por não ser o objetivo de seu trabalho ao tratar da midia local e comunitária como um
todo. Todavia, trata-se de uma das poucas referências bibliográficas para o estudo da prática do jornalismo impresso local e comunitário.
Some Operations on Mixed Monotone Operator in Banach Spaces
Authors: Badrulfalah Badrulfalah , Irianingsih I , Joebaedi Khafsah 
Published: November 2018

This paper discusses some operations on mixed monotone operator in Banach space, especially addition an multiplication operations. We will prove the sum and product of two mixed monotone operators. The proof using some relevant definitions. The result is the sum o of them is a mixed monotone operator and the product is too if both satisfy some conditions
War as nothing but a duel: war as an institution and the construction of the Western military profession
Authors: Käihkö Ilmari 
Published: November 2018

Abstract
Like all repetitive human interaction, even war has been institutionalized and fought according to conventions and norms. Historically, this institutionalization is apparent from the way war has been compared to the duel, first in the 14th century and most famously by Carl von Clausewitz 5 centuries later. This article continues this train of thought and argues that the observed limits of Western “professional orthodoxy” and “strategic vocabulary” can be traced to how war has been institutionalized by the military profession. This offers an alternative explanation to the prevailing views of why the West has struggled in contemporary wars: it is the fundamental mismatch between these professional norms in the West and those held by their opponents that forms the biggest asymmetry in contemporary war. As this asymmetry is unlikely to disappear, these professional norms need to be reconsidered: just like the aristocracy with the duel by the late 19th century, the Western military profession appears stuck in an institution that is increasingly becoming obsolete. Without such reconsideration, the attainment of decision – the central strategic objective in war – and hence victory in future wars will remain uncertain.
Wall-Sided Glaciers
Authors: Lewandowski Wojciech , Zgorzelski Marek 
Published: November 2018

Abstract
In the literature devoted to geomorphology and glaciology not much has been written about wall-sided glaciers, thanks to which high mountains have their specific landscape character. It is also difficult to find in the literature of the subject a classification of the wallsided glacier forms which would take into account the richness and variety of this phenomenon. After many years of experience in almost all highest mountains of Asia, South America and Europe, the authors decided to fill this gap and therefore to provoke a discussion among the geomorphologists.
Change of Grain Size Parameters of Sediments as a Result of Wind Activity. Barchans Jarangiyn Els in Gobi, Mongolia
Authors: Potocki Mariusz , Angiel Piotr 
Published: November 2018

Abstract
Research conducted on the Jarangiyn els field on the Gobi desert in Mongolia took place during the transformation of barchans resulting from the changes in wind direction. The investigation undertaken by the authors had as its goal the evaluation of the changes in the morphology of the forms, extended by the interpretation of the grain size parameters distribution in the longitudinal profiles of the dunes. The results indicate that the processes of barchan transformation are recorded in grain size parameters.
The Effect of Changes in Administrative Division on the Economic Position of the Largest Cities in Poland
Authors: Wilk Waldemar 
Published: November 2018

Abstract
Among the functions fulfilled by cities in relation to their hinterland, an important function is that of public administration. Changes in administrative division, instituted in Poland in 1999, have either weakened or strengthened the economical role of many cities.
A city’s position within the hierarchy of the centers of public administration within a country has, in Poland’s case, a significant effect upon the geographical movements of companies. An attempt was made to preliminarily gauge the effect of administrative changes upon the location of corporate offices. Changes in the distribution of companies providing the selected types of services in the 100 largest Polish cities were taken into account. The relationship between the change in the number of companies in each city and the potential social and economic role of the city in the general sense was examined.
Nature and Tourism on Tropical and Subtropical Islands
Authors: Jędrusik Maciej 
Published: November 2018

Abstract
Tropical and subtropical islands have become an important tourist destination. The islands are concentrated in eight areas of the world. Evaluating the natural tourist potential of these areas, it seems that the most attractive are the islands of Mid and West Indian Ocean and the Polynesia. Yet, these locations are less popular then the theoretically less naturally attractive Caribbean, Mediterranean and East Atlantic islands.
This leads to the conclusion that nature is not the most important decisive factor in choosing tourist destinations, and “tourist paradises” are formed on islands regardless of their natural attributes. Tourists are mainly attracted by the “myth” of a tropical island, and the most important criterion is the distance from home and travel time.
Geographical Research of the 30th Polish Antarctic Expedition at Arctowski Polish Station (King George Island, South Shetland Islands, Antarctica)
Authors: Angiel Piotr 
Published: November 2018

Abstract
This paper presents the scope of geographical research conducted at Arctowski Station during the 30th Polish Antarctic Expedition. The research included meteorological, climatological, geomorphological and glaciological issues. During the expedition, research was conducted on sandur sediments on the outwash plain of Sphinx Glacier, the size of the aeolian transport, intensity of periglacial phenomena, and the way in which environmental conditions are recorded on quartz grains collected on the Admiralty Bay beaches. Detailed measurements of the basic meteorological components were made, geomorphological maps of the outwash plains of Sphinx, Baranowski, and Windy Glaciers were also completed.
Cyclic Changes of Climate in Europe During the Last Millenium According to Dendrological Data
Authors: Boryczka Jerzy , Stopa-Boryczka Maria , Bijak Szymon 
Published: November 2018

Abstract
The paper discusses periodic climate changes in Europe determined on the basis of dendrochronological data dating back one thousand years. In tree-ring width sequences of trees growing in Poland there are approximately 8-, 11-, 100- and 180- year periods. The tree-ring widths of oaks growing in Poland for the last centuries are characterised, without any significant amplitude, by 8- and 11-year periods (Tab. 1). In turn, chronologies of pine, spruce, larch, oak and fir growing in Europe are characterised by 100- and 180-year periods (Tab. 2). Cycles of dendrochronological variables approximate cycles of air temperature and North Atlantic Oscillation NAO as well as those of solar activity. The forecast of annual growth (ring width) for 2001-2100 was calculated by interference of the tree-ring width cycles determined by the sinusoidal regression method. Because of much longer empirical sequences of specific periods, the credibility of forecasts for tree-ring widths is greater than that for air temperature.
Tourism in Rural Areas of Castilla-La Mancha
Authors: Zwierzchowska Joanna 
Published: November 2018

Abstract
The rural areas of Castilla-La Mancha have managed to preserve a unique natural and cultural character. A great diversity of touristic qualities makes the region especially attractive for development of rural tourism.
For many years, the autonomous community of Castilla-La Mancha had to cope with numerous socio-economic difficulties. Development of the tourist industry resulted in diversification of income sources and higher level of employment. Another positive effect of the process was activation of female members of the community. The principle aim of this article is to underline the complementary role of tourism in rural areas in relation to agriculture and urban tourism.
Stages of Development of Cartography as a Science
Authors: Ostrowski Wiesław 
Published: November 2018

Abstract
Three essential periods may be singled out in the development of cartography as a science:
1. From the beginning of the last century to the mid-sixties is the period of development of cartography as a distinct science.
2. The period dating from the mid-sixties till the eighties is the golden age of development of theoretical cartography with special amplification of discussions on the subject of the theoretical fundamentals of cartography. At the end of the former period and at the beginning of the latter, cartography finally distinguished itself as an independent science. In 1959, the International Cartographic Association was founded. In 1961, the International Yearbook of Cartography was published for the first time and beginning in 1969, Polski Przegląd Kartograficzny (the Polish Cartographic Review). A year earlier, Komisja Kartograficzna Polskiego Towarzystwa Geograficznego (the Cartographic Commission of the Polish Geographical Society) was established.
3. Since the mid-eighties, and even somewhat earlier, use of new IT technologies, especially interest in the map as an element of geographic information systems, has become the dominating trend in cartography.
Bioclimatic Conditions of Paris, Rome and Budapest on the Basis of the Universal Thermal Climate Index
Authors: Idzikowska Danuta 
Published: November 2018

Abstract
The aim of this study was to examine the main features of the bioclimatic conditions of three European cities using a new Universal Thermal Climate Index. Daily values of meteorological variables for 12 UTC for the cities for 1990-2001 were used in the study. Using the frequency of UTCI and one-way Anova, the results showed that in all the three cities “no thermal stress” dominated throughout the year. “Extreme” values of heat as well as “cold stress” were observed but in none of the cities “extreme cold stress” occurred. The values of UTCI differed for all the three cities in each studied year. The cities differed from each other in each month during the whole year with the exception of spring - March and April.
Regional Conditions for Maximum Probable Discharge in Poland’s Rivers
Authors: Gutry-Korycka Małgorzata , Woronko Dariusz , Suchożebrski Jarosław 
Published: November 2018

Abstract
The purpose of this study was to obtain and verify the methods of catchment regionalization for annual maximum discharge. An identification of Polish rivers was performed based on regional frequency analyses including recognition of regions homogeneous with respect to their physical properties and river flow parameters. The results suggest a division into two regional groups: mountain and lowland catchments. Statistical tests verify the regionalization obtained and allow to calculate regional probability curves for these two catchment groups. The results obtained may be helpful in the analysis of floods in ungauged catchments and in those where hydrological observations were performed during a short period, especially when the dependence of the maximum probable flows on their physico-geographical features in catchments under analysis has been proved.
The Peripheral Housing Estate as a Form of Urban Spatial Development. The Status Quo and Perspectives
Authors: Pieniążek Marek 
Published: November 2018

Abstract
Presentation of contemporary trends in development of such residential units as peripheral housing estates in large Polish cities, as exemplified by Warsaw, is the objective of the paper. Such units are compared with their counterparts being built in Berlin.
Research was carried out in three housing estates in the western part of the Bemowo District of Warsaw, i.e. Lazurowa (developer J.W. Construction), Nad Jeziorem (developer DoR Group) and Villa L’Azur (developer Bouygues Immobilier Polska). The first two were completed at the turn of 2008/2009. The third is in the final stage of construction. All three are located inside immediate city borders.
Within framework of research were carried out analysis of developers’ materials, cartographic materials from the City Hall as well as field research. The results were juxtaposed with research made in 2008 in Berlin.
The International Baccalaureate Diploma Programme in Central European Education Systems
Authors: Bobiatyńska Marta 
Published: November 2018

Abstract
The International Baccalaureate Diploma Programme has been introduced in the Central and Eastern European countries since the beginning of the 1990s. Developed in the 1960s by the International Baccalaureate Organisation in Geneva, it became since then an important part of the world educational system. The number of schools authorised by the International Baccalaureate Organisation (IBO) to offer the International Baccalaureate Diploma Programme (IBDP) has increased considerably. This paper aims to present the history of the International Baccalaureate Diploma Programme in nine countries of Central and Eastern Europe (Bulgaria, The Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania and Slovakia).