bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hardware Complication Risks in Head and Neck Cancer Patients Undergoing Reconstructive Surgery With Segmental Mandibulectomy
Authors: Chen Kevin Yu‐Ting , Chen Angela Chien‐Yu , Tsao Chung‐Kan , Hung Shao‐Yu , Cheong David Chon‐Fok , Kao Huang‐Kai 
Published: November 2024

ABSTRACTBackgroundThe primary objective of this study was to ascertain the risk factors associated with hardware complications following segmental mandibular reconstruction in head and neck cancer patients. Additionally, we sought to develop a nomogram model that enables accurate risk prediction.MethodsPatients who underwent segmental mandibulectomy with immediate free or local regional tissue transfer between January 2016 and December 2020 were reviewed. Hardware complications were defined. Patient demographics and perioperative parameters were analyzed.ResultsA total of 510 patients were analyzed. Postoperative radiation therapy (OR = 2.296, 95% CI = 1.339–3.938, p = 0.003), postoperative wound infection (OR = 2.367, 95% CI = 1.472–3.806, p < 0.001), and debridement for flap‐related complications (OR = 5.484, 95% CI = 3.269–9.199, p < 0.001) were identified as independent risk factors. The nomogram model demonstrated good discriminatory ability.ConclusionThis comprehensive analysis identified three independent risk factors, and the nomogram provides a valuable tool for predicting the risks. Further research is needed to validate these findings and explore preventive strategies.
Analytical Investigation on Flow Reversal in a Fully Developed Steady Mixed Convection Flow With Boundary Condition of the Third Kind
Authors: Jha Basant K. , Hussaini Ayyub M. , Altine Muhammad M. 
Published: November 2024

ABSTRACTThis work presents exact solutions to analyze the effect of the Biot number on mixed convection flow in a vertical channel with asymmetric heating and flow reversal. The equations governing flow formation and temperature distributions are offered with convective boundary conditions. Closed‐form solutions for temperature, velocity, and skin friction are found and simulated graphically.
The Complex Relationship Between Chronic Obstructive Pulmonary Disease With Cardiovascular Disease and Their Interactions With COVID‐19 Vaccination: A Retrospective Study
Authors: Hassan Muhammad Muneeb , Sikandar Sheikh Muhammad , Jamal Farrukh , Ameeq Muhammad , Kargbo Alpha 
Published: November 2024

ABSTRACTBackgroundPreviously, most researchers explored the association between chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). This study investigates the distinct influence of COVID‐19 vaccination status on patients with both conditions.ObjectiveWe investigate the relationship between COPD and CVD in a cohort of 838 individuals who presented with both conditions. Our aim is to understand how these conditions interact and how COVID‐19 vaccination status affects patient outcomes.MethodsA retrospective analysis was conducted on 838 patients with COPD and CVD treated at DHQ Hospital in Muzaffargarh, Punjab, Pakistan, from November 2022 to April 2023. We employed multiple logistic regression and the Wilcoxon signed‐rank test to assess the odds ratio and relative risk of COPD in patients with‐CVD under various conditions. Additionally, we analyzed time‐to‐death and survival using Kaplan–Meier methods.ResultsFindings reveal a 7.95 times higher risk of death in patients without COVID‐19 vaccination compared with those who were vaccinated (95% CI, 6.12–10.33). Conversely, COVID‐19‐vaccinated patients exhibited a 0.221 times lower risk of recovery than their nonvaccinated counterparts (95% CI, 0.08–0.60). We also observed significant differences in time‐to‐death and recovery based on the presence of COPD and CVD, with vaccinated patients generally experiencing milder disease.ConclusionOur study assessed the impact of COVID‐19 vaccination status on patient outcomes in patients with overlapping COPD and CVD. Individuals diagnosed with COPD and CVD display significant differences in terms of their probability of survival, with those who have received vaccinations.
Senescence in Intervertebral Disc Degeneration: A Comprehensive Analysis Based on Bioinformatic Strategies
Authors: Zhao Zijun , Wang Yining , Wang Zairan , Zhang Fan , Ding Ze , Fan Tao 
Published: November 2024

ABSTRACTBackgroundIntervertebral disc degeneration (IDD) is a major cause for low back pain. Studies showed the association between senescence and degenerative diseases. Cell senescence can promote the occurrence and development of degenerative diseases through multiple mechanisms including inflammatory stress, oxidative stress and nutritional deprivation. The roles of senescence and senescence‐associated genes (SAGs) remains unknown in IDD.MethodsFour differently expressed SAGs were identified as hub SAGs using “limma“ package in R. We then calculated the immune infiltration of IDD patients, and investigated the relation between hub SAGs and immune infiltration. Enrichment analysis was performed to explore the functions of hub SAGs in IDD. Nomogram and LASSO model based on hub SAGs was constructed to predict the risk of severe degeneration (SD) for IDD patients. Subsequently, single cell analysis was conducted to describe the expression pattern of hub SAGs in intervertebral disc tissue.ResultsWe identified ASPH, CCND1, IGFBP3 and SGK1 as hub SAGs. Further analysis demonstrated that the hub SAGs might mediate the development of IDD by regulating immune infiltration and multiple pathways. The LASSO model based on the four hub SAGs showed good performance in predicting the risk of SD. Single cell analysis revealed that ASPH, CCND1 and SGK1 mainly expressed in nucleus pulposus cells, while IGFBP3 mainly expressed in epithelial cells. Eleven candidate drugs targeting hub SAGS were predicted for IDD patients through Comparative Toxicogenomics Database (CDT). PCR and immunohistochemical analysis showed that the levels of four hub SAGs were higher in SD than MD (mild degeneration) patients.ConclusionsWe performed a comprehensive analysis of SAGs in IDD, which revealed their functions and expression pattern in intervertebral disc tissue. Based on hub SAGs, we established a predictive model and explored the potential drugs. These findings provide new understandings of SAG mechanism and promising therapeutic strategies for IDD.
Characteristics and outcomes of patients with postpartum hemorrhage undergoing transcatheter arterial embolization: A nationwide observational study
Authors: Kamijo Kyosuke , Nakajima Mikio , Shigemi Daisuke , Kaszynski Richard H. , Ohbe Hiroyuki , Goto Tadahiro , Sasabuchi Yusuke , Fushimi Kiyohide , Matsui Hiroki , Yasunaga Hideo 
Published: November 2024

AbstractObjectiveTo elucidate the demographics, clinical characteristics, and outcomes of patients with postpartum hemorrhage (PPH) who underwent transcatheter arterial embolization (TAE).MethodsWe conducted a retrospective observational study using the Japanese Diagnosis Procedure Combination inpatient database, which covers roughly 90% of all tertiary emergency hospitals in Japan, between April 2012 to March 2020. We identified patients with PPH who underwent TAE using the Japanese medical procedure status and code, and the device or drug code. We examined the patient characteristics, interventions administered, and clinical outcomes.ResultsAmong 64 893 patients diagnosed with PPH, we identified 2705 (4.2%) patients with PPH who underwent TAE. The most common cause of PPH was uterine atony (68.7%), followed by disseminated intravascular coagulation after labor (30.0%) and placenta accreta spectrum disorders (23.4%). The proportion of patients who underwent repeat TAE and a hysterectomy was 64 (2.4%) and 188 (7.0%), respectively. Among hysterectomies (n = 188), 26 (13.8%) had the procedure performed before TAE, 73 (38.8%) underwent hysterectomy on the same day as TAE, and 89 (47.4%) had the procedure conducted after TAE. Of those who underwent a hysterectomy after TAE (n = 89), 33 (37%) were performed more than 1‐week after initial TAE. Overall in‐hospital mortality was 14/2705 (0.5%).ConclusionEven if hemostasis is achieved through TAE, one must be mindful that a hysterectomy may become necessary more than 1 week after the procedure. These results could be helpful in clinical decision making and providing patients with additional treatment options for PPH that preserve patient fertility.
In Vitro and Vivo Experiments Revealing Astragalin Inhibited Lung Adenocarcinoma Development via LINC00582/miR‐140‐3P/PDPK1
Authors: Bai Juncheng , Chen Yuxin , Zhao Geyu , Gui Rong 
Published: November 2024

ABSTRACTThis study aimed to explore the mechanism of the development of lung adenocarcinoma (LUAD) treated by astragalin. Transcriptome sequencing was performed to obtain the gene profile of LUAD treated by astragalin. Combining with bioinformatics analysis including differential gene screening, function enrichment analysis (gene ontology and KEGG), and ceRNA construction, we obtained the novel mechanism of lncRNA mediated miRNA/mRNA axis. Then, the cell experiments were performed to examine the role of lncRNA in cell proliferation, migration and invasion, and apoptosis for LUAD treated with astragalin. Moreover, the tumor formation in nude mice was carried out to detect the ceRNA mechanism in LUAD treated by astragalin in vivo. The lncRNA mediated ceRNA network was obtained, that is, LINC00852 LINC00582/miR‐140‐3p/PDPK1 played an important role in LUAD treated by astragalin. Function experiments indicated that si‐LINC00852 inhibited LUAD cell proliferation, migration and invasion, and promoted cell apoptosis via miR‐140‐3p/PDPK1 (p < 0.05, p < 0.01). The animal experiments further confirmed that si‐LINC00852 inhibited tumor growth through miR‐140‐3p/PDPK1 in vivo. Conversely, this study provides comprehensive insights into the diagnostic and therapeutic implications of LINC00582 in LUAD, LINC00582 mediated miR‐140‐3p/PDPK1 axis was the novel drug target of astragalin for treating LUAD.
Tic‐Tac‐Toe on Designs
Authors: Danziger Peter , Huggan Melissa A. , Malik Rehan , Marbach Trent G. 
Published: November 2024

ABSTRACTWe consider playing the game of Tic‐Tac‐Toe on block designs BIBD and transversal designs TD. Players take turns choosing points and the first player to complete a block wins the game. We show that triple systems, BIBD, are a first‐player win if and only if . Further, we show that for , TD is a first‐player win if and only if . We also consider a weak version of the game, called Maker–Breaker, in which the second player wins if they can stop the first player from winning. In this case, we adapt known bounds for when either the first or second player can win on BIBD and TD, and show that for Maker–Breaker, BIBD is a first‐player win if and only if . We show that TD is a second‐player win, and so the second player can force a draw in the regular game by playing the same strategy.
Entrustable professional activities (EPAs) in postgraduate periodontics programs in Saudi Arabia: A modified Delphi study
Authors: Aldahlawi Salwa A. , Zaini Rania G. , Almoallim Hani M. 
Published: November 2024

AbstractPurposeThe purpose of this study was to obtain a validated consensus among expert periodontists in Saudi Arabia regarding end‐of‐periodontics‐residency‐training entrustable professional activities (EPAs) using a modified Delphi method.MethodsThe study consisted of two phases. A preliminary phase in which experts met and proposed an initial list of EPAs following an extensive literature review. The second phase consisted of two rounds of the modified Delphi method in which expert periodontists in Saudi Arabia determined the content validity of each EPA. This was determined with a 5‐point scale ranging from 1 (not important/relevant) to 5 (very important/relevant), and the mean score for each EPA was calculated. EPAs with a mean value of ≤ 4 or agreement rate among experts of less than 80% were excluded.ResultsAn initial list of 40 EPAs was proposed. A total of 30 expert periodontists participated in the first round, and 24 participated in the second round of the modified Delphi method ratings. Most of the participants were program directors and represented different programs and cities in Saudi Arabia. Five EPAs were removed, and a final list of EPAs was produced based on the defined criteria. The Cronbach's alpha was 0.920, indicating high reliability.ConclusionsA final list of 35 end‐of‐periodontics‐training EPAs was produced. The findings of this study can serve as a valuable resource for curriculum development, assessments, and evaluation of periodontics training programs in Saudi Arabia.
Current trends in types of pancreatoduodenectomy: Focus on the advancement of robot‐assisted pancreatoduodenectomy with 630 consecutive cases
Authors: Lee Mirang , Chae Yoon Soo , Park Seulah , Yun Won‐Gun , Jung Hye‐Sol , Han Youngmin , Kwon Wooil , Park Joon Seong , Jang Jin‐Young 
Published: November 2024

AbstractBackgroundPancreatoduodenectomy (PD) is a complex abdominal surgery, and the adoption of robotic PD has been on the rise because of its numerous benefits. This study aimed to investigate the current PD trends, focusing on advancements in robotic surgery.MethodsBetween 2015 and 2023, 1231 patients underwent open PD, whereas 630 underwent robot‐assisted PD (RAPD). Demographics and surgical outcomes were analyzed according to the time period. Moreover, a propensity score‐matched (PSM) analysis was performed to evaluate the clinical outcomes.ResultsThe proportion of RAPD cases gradually increased from 6.3% in 2015 to 50.9% in 2020, reaching a plateau of >50% thereafter. The proportion of patients receiving neoadjuvant chemotherapy increased during the late period (11.4% vs. 17.6%), with many of these patients undergoing open PD. Additionally, RAPD was performed in patients with a high probability of postoperative pancreatic fistula. However, the two groups demonstrated no significant difference in the occurrence of clinically relevant postoperative pancreatic fistula (10.6% vs. 9.5%, p = .532). Among periampullary cancer cases, RAPD demonstrated comparable survival outcomes to open PD after PSM (5‐year survival rate: 61.8% vs. 49.8%, p = .189).ConclusionsRAPD has become a stable approach, accounting for over 50% of all PD cases in high‐volume centers, and it can be safely performed. However, open PD remains important owing to the development of neoadjuvant therapy and the aging population. Therefore, establishing appropriate indications to maximize the benefits of both RAPD and open PD is necessary.
Fresh as a daisy: Within‐person associations between sleep, vitality, and self‐ and other‐rated job performance
Authors: Abrahams Loes , Hofmans Joeri , De Fruyt Filip 
Published: November 2024

SummaryFrom a resource perspective, employees' sleep quality, sleep duration, and feelings of vitality are believed to predict important work‐related outcomes. However, many studies ignore the dynamic nature of the constructs or rely primarily on self‐reported data. Including both self‐ and other‐ratings of daily job performance, we examined the extent to which daily sleep quality and duration predict daily job performance, and whether these relationships are mediated by vitality. Student teachers (N = 165), internship supervisors (N = 97), and students (i.e., targets; N = 69 classes) participated in an experience sampling study with morning assessments of sleep duration and quality (n = 1,762 and n = 869), and two daily assessments of vitality (n = 2,207) and performance (self‐, supervisor‐, and target‐rated; n = 2,160, n = 1,113, and n = 1,087). Multilevel path analyses suggested that 1) sleep quality but not duration predicted individuals' vitality and self‐ and target‐rated job performance, 2) vitality was positively associated with performance according to each rating source, and 3) midday vitality did not predict afternoon performance, nor did it mediate the relationship between sleep and afternoon performance. Implications for theory and practice are discussed.
Quantitative Ultrasound Parameters as Predictors of Chemotherapy Toxicity in Lymphoma
Authors: Sun Yang , Huang Jianqiu , Shao Jinhua , Luo Jianwen , He Qiong , Cui Ligang 
Published: November 2024

ObjectivesThe aim of this study was to use quantitative ultrasound (QUS) parameters to assess the muscle mass and quality in patients with lymphoma. Additionally, the study aimed to investigate the relationship between these QUS parameters and post‐chemotherapy myelosuppression.MethodsThe study cohort comprised 202 patients diagnosed with lymphoma (105 males, 97 females; mean age 57.0 ± 14.9 years). The skeletal muscle index (SMI) and mean skeletal muscle density (SMD) were measured on CT and used as the gold standards to evaluate low skeletal muscle mass and quality. The muscle thickness (MT) of the forearm flexor and extensor muscles was measured in both the relaxed and contracted states, while the normalized non‐linear parameter B/A (MusQBOX.NLP) and normalized mean intensity (MusQBOX.NMI) were extracted from retained ultrasound radiofrequency signals. The correlations between the QUS parameters and grip strength were assessed. Models were constructed using these QUS parameters to predict low SMI and SMD, and to evaluate whether these factors were independently associated with post‐chemotherapy myelosuppression.ResultsThe MT in both the relaxed and contracted states exhibited the strongest correlations with grip strength, while the MusQBOX.NLP and MusQBOX.NMI were only weakly correlated with grip strength. Models incorporating QUS parameters to predict low SMI and SMD achieved high area under the receiver operating characteristic curve values. The MT, MusQBOX.NLP, and MusQBOX.NMI were independent factors associated with post‐chemotherapy myelosuppression.ConclusionsQUS parameters show promise in characterizing muscle strength, mass, and quality. They are also independent factors influencing post‐chemotherapy myelosuppression.
Model Based on Ultrasound Radiomics and Machine Learning to Preoperative Differentiation of Follicular Thyroid Neoplasm
Authors: Deng Yiwen , Zeng Qiao , Zhao Yu , Hu Zhen , Zhan Changmiao , Guo Liangyun , Lai Binghuang , Huang Zhiping , Fu Zhiyong , Zhang Chunquan 
Published: November 2024

ObjectivesTo evaluate the value of radiomics based on ultrasonography in differentiating follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) and construct a tool for preoperative noninvasive predicting FTC and FTA.MethodsThe clinical data and ultrasound images of 389 patients diagnosed with FTC or FTA postoperatively were retrospectively analyzed at 3 institutions from January 2017 to December 2023. Patients in our hospital were randomly assigned in a 7:3 ratio to training cohort and validation cohort. External test cohort consisted of data collected from other 2 hospitals. Radiomics features were used to develop models based on different machine learning classifiers. A combined model was developed combining radiomics features with clinical characteristics and a nomogram was depicted. The performance of the models was assessed by area under the receiver operating characteristic curve (AUC), calibration curve and decision curve.ResultsRadiomics model based on random forest showed best performance in discriminating FTC and FTA, with AUCs 0.880 (95% confidence interval [CI]: 0.8290–0.9308), 0.871 (95% CI: 0.7690–0.9734), and 0.821 (95% CI: 0.7036–0.9389) in training, validation, and test cohort, respectively. The combined model presented better efficacy comparing with clinical model and radiomics model, with AUCs 0.883 (95% CI: 0.8359–0.9295), 0.874 (95% CI: 0.7873–0.9615), and 0.876 (0.7809–0.9714) in training, validation, and test cohort, respectively. The calibration curves suggested good consistency and decision curves showed the highest overall clinical benefit for the combined model.ConclusionsUltrasound radiomics model based on random forest is feasible to differentiate FTC and FTA, and the combined model is an intuitively noninvasive tool for FTC and FTA preoperative identification.
Thermal Treatment Induced Crystal Development and Crystal Orientation Change in Electrospun Coaxial Fibers Comprising Dual Crystalline Polymers
Authors: Hu Yu‐Rong , Lin Hsin‐Yu , Lo Chieh‐Tsung 
Published: November 2024

AbstractThis study investigates the crystallization behavior of electrospun coaxial fibers composed of crystalline poly(ethylene oxide) (PEO) in the core and crystalline poly(L‐lactide) (PLLA) in the sheath. The influence of cold crystallization temperature and premelting temperature on the crystallization of PEO and PLLA is investigated. At a cold crystallization temperature of ≤60 °C, PLLA remained immobile. PEO crystallization is hard‐confined, leading to a low degree of crystallinity. At a cold crystallization temperature of >60 °C, PEO melted, whereas PLLA crystallized. An increase in cold crystallization temperature results in an increase in the crystallite size and crystallinity of PLLA. Furthermore, the melt crystallization behavior of PEO in the coaxial fibers is strongly influenced by its premelting temperature and crystallization temperature. A higher premelting temperature leads to enhanced interdiffusion between PEO and PLLA. This increased confinement results in a decrease in PEO's crystallizability. Additionally, premelting relaxes the PEO chains, causing a shift in crystal orientation from parallel to the fiber axis (observed in as‐electrospun fibers) to perpendicular to the fiber axis (observed in melt‐crystallized fibers). Moreover, at a low melt crystallization temperature, demixing between PEO and PLLA is observed. This, coupled with a higher degree of supercooling, leads to an increase in PEO's crystallizability.
Monitoring the Persistence of Pseudomonas sivasensis Strain CF10PS3 in Cereal Fields
Authors: Delitte Mathieu , Dubois Benjamin , Mahillon Jacques , Debode Frédéric , Bragard Claude 
Published: November 2024

ABSTRACTThe persistence and efficacy of biocontrol agents in agricultural fields are crucial for sustainable crop production. In this study, we investigated the persistence of the introduced bacterial strain Pseudomonas sivasensis CF10PS3 in the wheat phyllosphere using a novel qPCR probe protocol. The CF10PS3 strain, known for its in vitro biocontrol properties against wheat pathogens, was applied through foliar spray, and its persistence was monitored over 7 weeks. Our qPCR assays, designed to specifically detect CF10PS3, distinguished it from naturally occurring P. sivasensis strains, providing precise insights into its dynamics in the field. The experimental results indicated that CF10PS3 was already present on the wheat leaves before its application, suggesting its natural adaptation to the foliar environment. Following initial application, a significant increase in CF10PS3 was observed, though subsequent environmental factors such as rain and wind might have caused notable fluctuations in its population. Despite these variations, the introduced strain showed considerable persistence, with population levels significantly higher than those in untreated plots by the end of the study period. This research underscores the importance of understanding bacteria dynamics in the field, highlighting the influence of environmental conditions on their efficacy. The use of specific qPCR probes proved effective in monitoring introduced strains, offering valuable insights for optimizing biocontrol agent application strategies. Our findings contribute to the development of robust biocontrol methods, promoting sustainable agricultural practices and enhancing crop protection.