bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Ethylene Glycol and DMSO on Fusion of Isolated Sarcoplasmic Reticulum Membranes
Authors: Stromer Marvin , The Rudy , Hasselbach Wilhelm 
Published: August 2018

Abstract
Membrane Fusion, Sarcoplasmic Reticulum, Ethylene Glycol, Dimethylsulfoxide Fragmented sarcoplasmic reticulum (FSR) vesicles from rabbit skeletal muscle were suspended in 5 - 10% ethylene glycol (EG) or in 5, 10, or 25% dimethylsulfoxide (DMSO) and were pelleted onto flat aluminum foil disks. No vesicle fusion occurs with either 5 or 10% EG treatment and 2-2½ hours drying. After 4-5 hours drying, 5% EG-treated vesicles have established more areas of close contact and individual vesicles have begun to flatten when compared with the 10% EG vesicles. Overnight drying results in formation of extended sheets of fused membranes called double bilayers in both the 5 and 10% EG samples. In the 5% EG-treated vesicles, formation of large spaces in the pellet compresses the adjacent bilayer pairs.
Extensive vesicle fusion accompanies 4 - 5 hours drying of both 5 and 10% DMSO-treated samples. No fusion was observed in the 25% DMSO-treated sample after 4-5 hours drying and individual vesicles remained round as in the 2-2½ hour samples of all treatments. Overnight drying also causes extended sheets of bilayer pairs to form in the 5% DMSO-treated samples but, with 10 and 25% treated vesicles, destroys the double bilayers and only occasional dense regions of membrane whorls remain. Both EG and DMSO promote more rapid fusion of FSR vesicles than does glycerol but overnight drying after treatment with 10 or 25% DMSO destroys the fused membrane.
Light-Dependent Interactions of Phenazine Methosulfate with 3-(3,4-Dichlorophenyl)-1,1-dimethylurea-Poisoned Chloroplasts
Authors: Schmidt Bernd , Rurainski Hans 
Published: August 2018

Abstract
The chlorophyll fluorescence of isolated chloroplasts in the presence of phenazine methosulfate (PMS) and 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) can be quenched in a light-dependent reaction. This phenomenan has been studied and the following observations were made:
1. Quenching occurs under non-phosphorylating conditions and is stimulated by Mg2+ ions.
2. Under the same conditions, a light-dependent, Mg2+ stimulated transient decrease of absorp­ tion at 388 nm is observed which shows the spectral characteristics of PMS.
3. PMS is reversibly bound to chloroplasts. Under the experimental conditions used, binding amounts to as much as 0.5 mol PMS/mol chlorophyll.
4. Some uncouplers of photophosphorylation such as carbonylcyanide-m-chlorophenylhydrazon (CCCP) and atebrin analog abolish quenching, transient absorption change and binding of PMS. Others, such as methylamine, ammonia, gramicidin and nigericin do not.
It is suggested that fluorescence quenching, transient absorption change and binding of PMS are causally related. The concept, postulated by others, that a high-energy state of the chloroplast membrane is involved in the fluorescence lowering is questioned.
On the Reaction of Methylmercuric Hydroxide with Methylcobalamin
Authors: Chu Victor C. W. , Gruenwedel Dieter W. 
Published: August 2018

Abstract
The methylmercury-induced dealkylation of the corrinoid coenzyme methylcobalamin, yielding aquocobalamin and dimethylmercury as products, was studied spectrophotometri-cally at 350 nm using water as a solvent. Rate data were determined for the pH 7-9 region and also at pH 3.37. Evidence is provided which shows that CH3Hg+ serves as the species which accepts the methyl group and also that Hg2+ is methylated more rapidly than CH3Hg+ is.
Enzymatische Bildung eines Muconsäurederivates mit Hilfe Pyrazonabbauender Bakterien / Enzymatic Formation of a cis,cis-Muconic Acid Derivative Using Pyrazon-Degrading Bacteria
Authors: Blobel Friedhelm , Eberspächer Jürgen , Haug Siegfried , Lingens Franz 
Published: August 2018

Abstract
The cis,cis-muconic acid derivative of pyrazon, which was formerly isolated from the medium of pyrazon-de-grading bacteria, was formed enzymatically by incubation of the catechol derivative of pyrazon with partially purified ortho pyrocatechase from pyrazon-degrading bacteria.
The Role of Exercise in the Management of Parkinson's Disease
Authors: Gallo Paul M. , Mendola Nicole M. 
Published: August 2018

ABSTRACT
PARKINSON'S DISEASE (PD) RESULTS IN MOTOR AND NONMOTOR SYMPTOMS THAT LEAD TO DECREASED MOBILITY AND REDUCED QUALITY OF LIFE. EXERCISE IS AN EFFECTIVE METHOD FOR DISEASE MANAGEMENT AND IMPROVED FITNESS IN PERSONS WITH PD. THIS COLUMN WILL FOCUS ON THE PATHOPHYSIOLOGY, EPIDEMIOLOGY, TREATMENT, AND EXERCISE GOALS FOR PERSONS WITH PD.
Spontaneous pregnancy after full recovery from hypopituitarism caused by lymphocytic hypophysitis
Authors: Funazaki Shunsuke , Yamada Hodaka , Hara Kazuo , Ishikawa San-e 
Published: August 2018

Summary
Lymphocytic hypophysitis (LyH) has been known to be associated with pregnancy. We herein report the case of a 33-year-old woman who underwent vaginal delivery without massive bleeding at 40 weeks of gestation. Because of the presence of headache and terrible fatigue after childbirth, she visited our hospital. Severe hyponatremia (Na, 118 mEq/L) and visual field abnormality was noted upon examination. MRI revealed pituitary enlargement with a swollen pituitary stalk, albeit at low signal intensity. Basal pituitary hormone levels were all reduced and remained low after exogenous administration of hypothalamic-releasing hormones. She was diagnosed with LyH and was started on prednisolone 60 mg/day. A month later, her pituitary function had gradually improved together with a decrease in pituitary enlargement and recovery of her visual field. The dose of prednisolone was gradually reduced and finally withdrawn 27 months later. After prednisolone withdrawal, her pituitary function remained normal despite the absence of any hormonal replacement. A year later, she became pregnant without medication and delivered a second baby without LyH recurrence. Thereafter, her pituitary function has been normal for more than 5 years. Two valuable observations can be highlighted from the case. First, the patient completely recovered from LyH through prompt prednisolone therapy during its initial phase and had almost normal pituitary function. Second, after recovery from LyH, she was able to undergo spontaneous pregnancy and deliver a baby. We believe that reporting incidences of spontaneous pregnancy after complete normalization of pituitary function in patients with LyH is of great significance.

Learning points:

Females are more affected by LyH than males given its strong association with pregnancy.

LyH possesses characteristic findings on pituitary MRI.

Glucocorticoid therapy for LyH has been recommended as an effective treatment.

A history of previous pregnancies does not increase the risk of developing AH in subsequent pregnancies.

Early induction of high-dose prednisolone was therapeutically effective in treating LyH.
ЕФЕКТИВНІСТЬ ТЕХНОЛОГІЧНОГО ОНОВЛЕННЯ ВИРОБНИЦТВА У СІЛЬСЬКОГОСПОДАРСЬКИХ ПІДПРИЄМСТВАХ
Authors: Sas L.S. 
Published: August 2018

У статті обґрунтовано необхідність здійснення технологічного оновлення виробництва у сільськогосподарських підприємствах з огляду на його ефективність. З’ясовано сутність поняття ефективності. Розглянуто ефективність технологічного оновлення виробництва сільськогосподарських підприємств як комплексне поняття.
Визначено й аргументовано аспекти розгляду ефективності щодо процесу технологічного оновлення виробництва у сільськогосподарських підприємствах, зокрема: з точки зору співвідношення ефекту та витрат; з огляду на досягнення мети; з точки зору зацікавлених сторін; як зовнішнє і внутрішнє поняття; з позиції результативності та мінімізації витрат; як максимально можливий результат при заданому наборі ресурсів; як якісний, кількісний та вартісний показник виробництва; як багаторівневе поняття; як комплексне поняття.
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ІНФОРМАЦІЙНА БЕЗПЕКА: АНАЛІЗ ОСНОВНИХ ЗАГРОЗ ДЛЯ УКРАЇНИ
Authors: Korol’ V.S. 
Published: August 2018

У сучасних умовах ХХІ ст. інформаційна безпека набуває все вагомішої ролі, а питання її забезпечення стають дедалі гострішими. Стрімке впровадження інформаційних технологій у всі сфери життєдіяльності суспільства та розвиток в умовах глобалізаційних процесів актуалізує проблему визначення обґрунтованих та ефективних шляхів забезпечення інформаційної безпеки.
Досліджено проблему інформаційної безпеки України та захисту національного інформаційного простору від негативних впливів. Проаналізовано теоретичні підходи до визначення сутності поняття інформаційна безпека; всебічно досліджено види реальних і потенційних інформаційних загроз для України. Визначено практичні рекомендації щодо вдосконалення державної інформаційної політики та створення ефективної системи інформаційної безпеки України
FINANCIAL SUPPLY OF SOCIO-ECONOMIC DEVELOPMENT OF TERRITORIAL COMMUNITIES IN DECENTRALIZATION CONDITIONS
Authors: Shchur R. I. , Kokhan I. V. 
Published: August 2018

The article considers conceptual implications of financial provision of socio-economic development of communities in the condition of decentralization. The dynamics of revenues is analyzed of united territorial communities in Ukraine in 2015-2017. The main financial tools are investigated of stimulation of socio-economic development of territorial communities in Ukraine.
Ultrasonography of Borderline and Asymmetric Infant Hips - a Challenge in the Management of Developmental Dysplasia of the Hip
Authors: Vasilescu Dan , Cosma Dan , Vasilescu Dana Elena , Solomon Carolina Maria , Corbu Andrei , Dudea Sorin Marian 
Published: August 2018

Background and aim. Developmental dysplasia of the hip (DDH) is a potentially disabling disease. There are many diagnostic approaches, Graf method ultrasonography being the most popular imaging method. Although considered as a healthy condition, the existence of hips at the 60 degree limit or the asymmetries higher than 4 degrees between left and right side may be a source of unfavorable evolution and consequently of late diagnosed dysplasia cases.Methods. The retrospective study was conducted in the Radiology Department of the Emergency Clinical County Hospital Cluj-Napoca, by retrospective analysis of the database containing 3013 records of the subjects presented for DDH assessment between January 2008 and December 2014. The study focuses on investigating two possible sources of missed cases by clinical-ultrasound management of DDH: borderline and asymmetric hips. Two conditions were studied in patients considered healthy according to Graf method: borderline hips (those with α angle value of 60° and 61°) and asymmetric hips (left to right difference between the α angle values exceeds 4°). Three study groups were formed: healthy subjects, asymmetric/borderline subjects and patients with immature or mild dysplasia. The incidence of risk factors, clinical suspicion and the success of therapy were evaluated. Results. There were no significant differences between the three groups regarding the role of the risk factors in DDH pathogenesis. Data reveal a high suspicion rate after the clinical examination, in groups II and III, compared to the healthy population. This means that from this point of view, Group II might be considered having at least a dysplastic prognosis. An increased correlation in the therapeutic results was observed between Group II patients and those from mild delayed maturation subgroups from Group III (IIa-, IIa+).Conclusions. Asymmetric and borderline hips should be approached similarly to immature hips, clinical suspicion and the therapeutic outcome being similar.
Prevalence of Autism Spectrum Disorder in Preterm Infants: A Meta-analysis
Authors: Agrawal Sachin , Rao Shripada C. , Bulsara Max K. , Patole Sanjay K. 
Published: August 2018

CONTEXT:Evidence is emerging that preterm infants are at risk for autism spectrum disorder (ASD).OBJECTIVES:To conduct a systematic review and meta-analysis to estimate the prevalence of ASD in preterm infants.DATA SOURCES:Medline (via PubMed and Ovid), Embase, PsycINFO, and relevant conference proceedings were searched in May 2017.STUDY SELECTION:Original studies in which researchers report on the prevalence of ASD using diagnostic tests in children born preterm were included. Studies in which researchers used only ASD screening tools were excluded.DATA EXTRACTION:Relevant data were extracted independently by 3 authors.RESULTS:Researchers in a total of 18 studies (3366 preterm infants) used ASD diagnostic tools. The median gestation, birth weight, and age at assessment were 28.0 weeks (range: 25.1–31.3 weeks), 1055 g (range: 719–1565 g), and 5.7 years (range: 1.5–21 years), respectively. Meta-analysis revealed that the overall prevalence rate for ASD was 7% (95% confidence interval: 4% to 9%). The funnel plot and Egger’s test revealed that there was probably no evidence of publication bias.LIMITATIONS:The limitations were significant heterogeneity and a lack of studies from middle- and low-income countries.CONCLUSIONS:The prevalence of ASD is significantly high in the preterm population. Adequate resources are needed to improve the outcomes of these children.
Використання комбінованого гравітаційного спуску деревини на схилах Карпат
Authors: Kyi V. V. , Tsymbalyuk Yu. І. , Kyi A. V. 
Published: August 2018

Розглянуто проблеми трелювання деревини під час лісорозробок у гірській місцевості, зокрема на схилах Карпат. Проаналізовано недоліки трелювання традиційними механізмами – трелювальними тракторами та канатними установками. Обґрунтовано можливість використання для гравітаційного спуску деревини на схилах Карпат пластикових лоткових систем. Зазначено недоліки застосування такої технології, зокрема проблеми, що виникають під час спуску довгомірних колод. Для вирішення проблеми спуску довгомірних сортиментів запропоновано застосувати комбінований гравітаційний спуск. Його суть полягає в тому, що короткомірні сортименти можна спускати по пластиковій лотковій ситемі, а довгомірні – за допомогою одновісного візка, що опирається на опорне самокерівне колесо. Воно рухається по лотку і в цьому випадку наявна лоткова система слугуватиме напрямним елементом, який скеровує рух візка у відповідному напрямку. Опорне самокерівне колесо повинно бути таким, щоб максимально заповнити переріз лотка і цим самим звести до мінімуму його поперечні рухи, унеможливлюючи вискакування колеса із напрямного лотка. Для завантаження візка передбачається встановити на нього завантажувальну систему, яку розробили науковці кафедри ЛПВ ЛД НЛТУ України, що захищена патентом. Після завантаження візка та закріплення на ньому вантажу, візок спускають вниз по схилу, регулюючи його рух утримувальним канатом. Внизу схилу, на наватажувальному майданчику, візок розвантажують і витягують знову на схил до пакету довгомірних сортиментів. Потім цикл повторюють.
Interferon-α Is Effective for Treatment of Minimal Residual Disease in Patients with t(8;21) Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Registry Study
Authors: Mo Xiao-Dong , Wang Yu , Zhang Xiao-Hui , Xu Lan-Ping , Yan Chen-Hua , Chen Huan , Chen Yu-Hong , Qin Ya-Zhen , Liu Kai-Yan , Huang Xiao-Jun 
Published: August 2018

AbstractBackgroundRUNX1-RUNX1T1 transcript levels were established as a powerful marker for predicting relapse in patients with t(8;21) acute myeloid leukemia (AML). We aimed to identify the efficacy of minimal residual disease (MRD)-directed interferon-alpha (IFN-α) treatment in patients with t(8;21) AML who were positive for MRD after allogeneic hematopoietic stem cell transplantation (allo-HSCT; n=42).Subjects, Materials, and MethodsMRD-positive status was defined as a &lt;4.5-log reduction from diagnosis in RUNX1-RUNX1T1 transcripts and/or the loss of a ≥4.5-log reduction after 3 months after HSCT. Patients with positive MRD received six cycles of IFN-α treatment (twice or thrice weekly of every 4 weeks cycle).ResultsThe 1-year cumulative incidence of severe acute and chronic graft-versus-host disease after MRD-directed IFN-α treatment was 7.1% and 4.8%, respectively. After the treatment, 15 (35.7%), 5 (11.9%), 3 (7.1%), and 9 (21.5%) patients achieved MRD negativity at 1, 2, 3, and &gt;3 months, respectively. Three patients relapsed after the IFN-α treatment, in which the 1-year cumulative incidence of relapse was 7.2%. One patient died of severe infection at 460 days after treatment. The 1-year probabilities of event-free survival, disease-free survival, and overall survival after treatment were 76.0%, 92.4%, and 92.5%, respectively. The clinical outcomes in patients who received MRD-directed IFN-α treatment were significantly better than those of the MRD-positive patients without any interventions in the historical cohort.ConclusionMRD-directed IFN-α treatment is effective for patients with t(8;21) AML who were MRD-positive after allo-HSCT. The study was registered at http://clinicaltrials.gov as NCT02027064.Implications for PracticeIn patients with t(8;21) acute myeloid leukemia (AML), the presence of post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) minimal residual disease (MRD), measured by RUNX1-RUNX1T1 transcript levels, has been established as a powerful marker for predicting relapse. Interferon-alpha (IFN-α) could exert a relatively strong graft-versus-leukemia effect, and MRD-directed IFN-α treatment is effective for patients with t(8;21) AML who were MRD-positive after allo-HSCT.
KEPOLISEMIAN VERBA TSUKERU: KAJIAN LINGUISTIK KOGNITIF
Authors: Suciaty Prisyanti , Sutedi Dedi , Herniwati Herniwati 
Published: August 2018

Polisemi merupakan salah satu tema yang dibahas ketika berbicara mengenai makna sebuah kata. Kata yang berpolisemi adalah kata yang memiliki makna lebih dari satu. Penelitian ini meneliti makna verba tsukeru yang berpolisemi. Verba tsukeru dianalisis dengan menggunakan kajian linguistik kognitif. Tujuan dari penelitian ini untuk mendeskripsikan makna dasar, mengklasifiksikan makna perluasan, serta mendeskripsikan hubungan antara makna dasar dan makna perluasan dari verba tsukeru. Metode yang dilakukan dalam penelitian ini adalah metode deskriptif. Data yang digunakan yaitu jitsurei yang diperoleh dari korpus BCCWJ (Balanced Corpus of Contemporary Written Japanese) yang bersumber dari dokumen, majalah, koran, buku pelajarann, buletin, dan yahoo yang terbit antara tahun 2000-2008. Selanjutnya dicatat dalam bentuk kartu data. Kemudian dilanjutkan dengan mengklasifikasikan data ke dalam makna dasar dan makna perluasan,dan menganalisis hubungan makna dasar dan makna perluasan menggunakan kajian linguistik kognitif yakni menurut majas metafora, metonimi, dan sinekdoke. Hasil penelitian yang ditemukan adalah verba tsukeru memiliki makna dasar memasang. Kemudian ditemukan 15 makna perluasan yaitu memberi, menempatkan, menambahkan, merendam, mencampurkan, menyalakan, mengoles, mengawasi yang masuk kepada perluasan metafora, selanjutnya menetapkan, mempekerjakan, dan menulis masuk ke peluasan metonimi, terakhir menggores, mengenakan, dan menghentikan perluasan makna sinekdoke. Selain itu ditemukan juga makna idiomatikal seperti membatasi, terbiasa, bertengkar, menuduh, lepas tangan, berhati-hati, memandang, mengerjakan, dan melengkapi diri.This paper present an analysis of tsukeru verb which have multiple meanings and in which the mulitple meanings of a word may be connected or related. While this analysis based on cognitive linguistics. The goal of this analysis is describe basic meaning and another meanings of tsukeru verb, and also describe relation of basic meaning and another meanings, and the last present meanings structure of tsukeru verb. The analysis using data form Balanced Corpus of Chunagon contemporary Written Japanese corpus presented by National Institute for Japanese Language and Linguistics. Sentence data in this paper based on document, magazine, newspaper, study books, bulletin, and yahoo at 2000-2008. This data clasification using data card (table data). Decription of relation basic meaning and another meanings using cognitive linguistics analysis which is metaphor, metonymy , and synecdoche. The result of this research is tsukeru verb have basic meaning is put on, and then founded 15 another meanings. Result are follow including metaphor are give, put, adding, soaking, mix, ignite, spreading, watching, including metonymy are decide, hiring, writing, and the last is including synecdoche are slash, dress, stop. Furthermore, fouded idiom meanings such as define, common, quarrel, accuse, hands off, be careful, starring at, doing, acquire.
PEMBELAJARAN KONTEKSTUAL DALAM NOVEL MADOGIWA NO TOTTOCHAN KARYA TETSUKO KUROYANAGI & NIJUUSHI NO HITOMI KARYA SAKAI TSUBOI
Authors: Andari Novi , Sudarwati Sudarwati 
Published: August 2018

Banyak pendidik mulai percaya bahwa proses belajar yang berpusat pada peserta didik akan membawa hasil yang lebih baik dan menghasilkan kesuksesan pada peserta didik tersebut. Inspirasi seorang pendidik dalam menentukan dan menciptakan metode dan model pembelajaran dapat diperoleh dari berbagai sumber. Novel adalah salah satu karya sastra yang berfungsi sebagai alat untuk mewakili kehidupan manusia sebagaimana dinyatakan dalam karya fiksi. Karena pesan yang disampaikan oleh penulis melalui novel bersumber dari permasalahan yang ada di masyarakat, salah satu masalahnya adalah pendidikan. Penjelasannya menjelaskan bahwa ada hubungan khusus antara novel dan pendidikan. Untuk membuktikan pernyataan di atas, dilakukan sebuah penelitian yang bertujuan untuk memperoleh data atau informasi bentuk pembelajaran dalam karya sastra. Ditemukan dalam novel Madogiwa no Totto-chan dan novel Nijuushi no Hitomi tentang bentuk pembelajaran untuk anak-anak sekolah dasar. Dalam tulisan ini dipaparkan temuan metode pembelajaran kontekstual pada dua novel tersebut. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Many educators are beginning to believe that the learning process centered on learners will bring better results and result in success in those learners. Inspiration of an educator in determining and creating methods and models of learning can be obtained from various sources. Novel is one of the literary works that serve as a tool to represent human life as stated in the work of fiction. Because the message conveyed by the author through the novel sourced from the problems that exist in the community, one of the problems is education. The explanation explains that there is a special connection between novel and education. To prove the above statement, conducted a study that aims to obtain data or information of the forms of learning in a literary work. Found in the novel Madogiwa no Totto-chan and novel Nijuushi no Hitomi about the forms of learning for elementary school children. In this paper that presented the findings of a method of contextual learning in the two novels. Research method used is descriptive qualitative method.