bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of voice and mental health diagnoses with differences in voice‐related care utilization
Authors: Jordan Victoria A. , Lunos Scott , Sieger Gretchen , Horvath Keith J. , Cohen Seth , Misono Stephanie 
Published: September 2019

ObjectiveTo compare healthcare utilization in voice patients with versus without mental health (MH) diagnosesStudy DesignRetrospective study using electronic medical records from large regional healthcare system.MethodsWe examined data on sociodemographic characteristics, comorbidities, voice‐related diagnoses, and patterns of healthcare utilization (including medication use, tests and procedures, and outpatient visits). The study period spanned January 2005 through June 2017.ResultsA total of 24,672 patients had at least one voice‐related diagnosis. Of these, 11,483 (47%) also had at least one MH diagnosis compared to 14% in the overall repository (P < 0.0001). The most common voice‐related diagnoses were nonspecific dysphonia (80%), acute laryngitis (30%), and vocal fold paresis/paralysis (7%). The 11,483 patients with both voice‐related and MH diagnoses were more likely to have acute laryngitis and/or nonspecific dysphonia; less likely to have laryngeal cancer and/or paresis/paralysis; and more likely to have seen a primary care provider, to have received medications, and to have undergone radiology studies. In contrast, the 13,189 patients with only voice‐related diagnoses had more overall voice‐related visits, were more likely to have seen an otolaryngologist, and were more likely to have undergone a voice evaluation with a speech language pathologist.ConclusionVoice patients with MH diagnoses were less likely to see otolaryngology and more likely to have radiology studies than voice patients without MH diagnoses. Further study is warranted to characterize temporal sequences of care in this group of patients and determine whether these differences are attributable to referral patterns from primary care.Level of Evidence4 Laryngoscope, 130:1496–1502, 2020
Survival analysis and decannulation outcomes of infants with tracheotomies
Authors: Salley Jordan , Kou Yann‐Fuu , Shah Gopi B. , Mitchell Ron B. , Johnson Romaine F. 
Published: September 2019

ObjectiveTo evaluate for differences in time to decannulation and survival rates for pediatric tracheotomy patients based on ventilator status upon discharge.Study DesignRetrospective longitudinal cohort study.MethodsA single‐institution longitudinal study of pediatric tracheostomy patients was conducted. Patients were categorized based on mechanical ventilation status on discharge and principal reason for tracheostomy. Survival rates were determined using the Kaplan‐Meier method. The Wilcoxon's Rank Sum test and Cox regression analysis evaluated differences in survival times and time to decannulation based on primary indication for tracheotomy and ventilation status.ResultsChart review identified 305 patients who required a tracheostomy under the age of 3. The median age at the time of tracheotomy was 5.2 months. The indications for tracheotomy in these patients were airway obstruction in 145 (48%), respiratory failure in 214 (70%), and pulmonary toilet in 10 (3.3%). Seventy‐nine percent of patients were ventilator dependent at discharge. At the conclusion of the study period, 55% of patients were alive with tracheostomy in place, 30% patients were decannulated, and 15% patients were deceased. Patients with ventilator dependence at initial discharge, bronchopulmonary dysplasia, or airway obstruction were more likely to be decannulated. Hispanic patients were less likely to be decannulated. Patients had an equal probability of death regardless of ventilator status at discharge.ConclusionsThis study demonstrated that the time to decannulation and likelihood of decannulation varies based on the indication for the tracheostomy. The majority of patients with a tracheostomy were not decannulated at the conclusion of this study. Median time to decannulation was 2.5 years for patients with a median death time of 6 months.Level of Evidence2b Laryngoscope, 130:2319–2324, 2020
Short‐Term Administration of a High‐Fat Diet Impairs Wound Repair in Mice
Authors: Schanuel Fernanda S. , Romana‐Souza Bruna , Monte‐Alto‐Costa Andréa 
Published: September 2019

AbstractHigh intake of dietary fat plays an important role in obesity development in animals and humans, and prolonged intake of high‐fat diet might lead to low‐grade chronic inflammation. Previous study showed that diet‐induced overweight delays cutaneous wound healing in both obesity‐prone and obesity‐resistant animals, highlighting the importance of diet composition in the wound healing process. This study evaluated the hypothesis that a short‐term administration of high‐fat diet could affect cutaneous wound healing. Male mice (C57/bl6) were randomly divided into standard (10% energy from fat) or high‐fat (60% energy from fat) chow groups. After 10 days of diet administration, an excisional lesion was performed and the animals were sacrificed 6 or 10 days later. There was no difference in the fasting blood glucose between groups. Ten days after wounding, high‐fat chow group presented increased inflammatory infiltrate, levels of inducible nitric oxide synthase and cyclo‐oxygenase‐2 proteins, and lipid peroxidation. The high‐fat chow group presented delayed wound closure, increased amount of myofibroblasts and vessels, and decreased deposition of type I collagen. These findings support the hypothesis that short‐term administration of high‐fat diet exerts negative effects on mice cutaneous wound healing, due to the interference in the inflammatory phase.
Organic Single‐Crystalline Semiconductors for Light‐Emitting Applications: Recent Advances and Developments
Authors: Ding Ran , An Ming‐Hui , Feng Jing , Sun Hong‐Bo 
Published: September 2019

AbstractOrganic single‐crystalline semiconductors (OSCSs), as a vital branch of organic semiconductors, have recently attracted intense interest due to their numerous advantages such as highly ordered structure, high carrier mobility, high thermal stability, and low impurity levels, and they have worldwide use in different kinds of applications. In particular, the nature of better luminescence properties and remarkable charge‐transport characteristics is a prerequisite for light‐emitting aspects. Here, a concise overview of the recent progress on OSCSs research is provided, highlighting the prominent properties of OSCSs which are pertinent to light‐emitting behavior. Various crystal‐growth strategies are surveyed for the preparation of high‐quality OSCSs via solution, melting, and vapor phases. Two typical electrical‐pumping light‐emitting devices, including organic light‐emitting transistors and organic light‐emitting diodes, are summarized with recent advances and developments exhibiting the latent potentialities of OSCSs in optoelectronics.
Generating Triple Crystalline Superstructures in Melt Miscible PEO‐b‐PCL‐b‐PLLA Triblock Terpolymers by Controlling Thermal History and Sequential Crystallization
Authors: Palacios Jordana K. , Liu Guoming , Wang Dujin , Hadjichristidis Nikos , Müller Alejandro J. 
Published: September 2019

AbstractThe morphology, crystallization behavior, and properties of multi‐crystalline polymer systems based on triple crystalline biodegradable PEO‐b‐PCL‐b‐PLLA triblock terpolymers are reviewed. The triblock terpolymers, with increasing poly(l‐lactide) (PLLA) content, exhibit a triple crystalline nature. Upon cooling from melt, the PLLA block crystallizes first and templates the spherulitic morphology of the terpolymer. Then, the poly(ε‐caprolactone) (PCL) block crystalizes and, finally, the poly(ethylene oxide) (PEO) block. These triblock terpolymers are melt miscible according to small angle X‐ray scattering (SAXS) results. Thus, the crystallization of PCL and PEO blocks takes place within the interlamellar zones of the PLLA spherulites that are formed previously. Therefore, the lamellae of PLLA, PCL, and PEO exist side‐by‐side within a unique spherulite, constituting a novel triple crystalline superstructure. The theoretical analysis of SAXS curves implies that only one lamella of either PCL or PEO can occupy the interlamellar space in between two contiguous lamellae of PLLA. Several complex competitive effects such as plasticizing, nucleation, anti‐plasticizing, and confinement take place during the isothermal crystallization of each block in the terpolymers. New results on how successive self‐nucleation and annealing thermal treatment can be used as an additional suitable technique to properly separate the three crystalline phases in these triple crystalline triblock terpolymers are also included.
Strontium Isopropoxide: A Highly Active Catalyst for the Ring‐Opening Polymerization of Lactide and Various Lactones
Authors: Bandelli Damiano , Weber Christine , Schubert Ulrich S. 
Published: September 2019

AbstractCommercially available strontium isopropoxide represents a suitable catalyst/initiator for the ring‐opening polymerization (ROP) of lactide (LA), ε−caprolactone, δ−valerolactone, δ−caprolactone, and δ−decalactone. Well‐defined polyesters are accessible via the solution polymerization of lactide in toluene with a [LA]:[Sr] ratio of 100:1 at room temperature with or without the addition of dodecanol as coinitiator. Kinetic studies and detailed analysis by means of matrix‐assisted laser desorption ionization mass spectrometry reveal pseudo‐first‐order kinetics of the ROP as well as excellent endgroup fidelity of the polylactide (PLA) with isopropyl and dodecyl α‐endgroups. Both isopropanolate moieties as well as the coinitiator each initiate PLA chains, enabling the synthesis of PLA with tailored molar mass. The polymerization of ε−caprolactone and δ−valerolactone confirms the high catalyst activity, which causes quantitative monomer conversion after 1 min polymerization time but broad molar mass distributions. In contrast, the catalyst is well suited for the ROP of the less reactive δ−caprolactone and δ−decalactone. Although kinetic studies reveal initially bimodal molar mass distributions, polyesters with dispersity values Ð < 1.2 and unimodal molar mass distributions can be obtained at moderate to high monomer conversions.
A method for real‐time temporal disaggregation of blended radar–rain gauge precipitation fields
Authors: Barton Yannick , Sideris Ioannis V. , Germann Urs , Martius Olivia 
Published: September 2019

AbstractA fully automated quasi‐real‐time method is presented to disaggregate hourly to sub‐hourly precipitation information operationally in a blended radar–rain gauge product. The method proposes a fully automated solution to disaggregate precipitation in regions characterized by measurement errors or partial absence of auxiliary information on the temporal precipitation evolution. The solution relies on a combination of low‐pass filtered radar information and stochastically generated noise fields. A comprehensive validation of the new method is provided demonstrating higher skill compared to a uniform disaggregation in time. The method is now an integral part of CombiPrecip, the official operational code of MeteoSwiss for radar–rain gauge merging.
Glycogen storage diseases: Twenty‐seven new variants in a cohort of 125 patients
Authors: Sperb-Ludwig Fernanda , Pinheiro Franciele Cabral , Bettio Soares Malu , Nalin Tatiele , Ribeiro Erlane Marques , Steiner Carlos Eduardo , Ribeiro Valadares Eugênia , Porta Gilda , Fishinger Moura de Souza Carolina , Schwartz Ida Vanessa Doederlein 
Published: September 2019

AbstractBackgroundHepatic glycogen storage diseases (GSDs) are a group of rare genetic disorders in which glycogen cannot be metabolized to glucose in the liver because of enzyme deficiencies along the glycogenolytic pathway. GSDs are well‐recognized diseases that can occur without the full spectrum, and with overlapping in symptoms.MethodsWe analyzed a cohort of 125 patients with suspected hepatic GSD through a next‐generation sequencing (NGS) gene panel in Ion Torrent platform. New variants were analyzed by pathogenicity prediction tools.ResultsTwenty‐seven new variants predicted as pathogenic were found between 63 variants identified. The most frequent GSD was type Ia (n = 53), followed by Ib (n = 23). The most frequent variants were p.Arg83Cys (39 alleles) and p.Gln347* (14 alleles) in G6PC gene, and p.Leu348Valfs (21 alleles) in SLC37A4 gene.ConclusionsThe study presents the largest cohort ever analyzed in Brazilian patients with hepatic glycogenosis. We determined the clinical utility of NGS for diagnosis. The molecular diagnosis of hepatic GSDs enables the characterization of diseases with similar clinical symptoms, avoiding hepatic biopsy and having faster results.
The super thin external pudendal artery (STEPA) free flap for oropharyngeal reconstruction – A case report
Authors: Dupret‐Bories Agnès , Roumiguie Mathieu , De Bonnecaze Guillaume , Sarini Jérome , Vairel Benjamin , Vergez Sébastien , Benbassat Bastien 
Published: September 2019

AbstractThe radial forearm flap is one of the most used micro‐anastomotic flaps in cervicofacial reconstruction in a carcinological context. This flap is an ideal in terms of reliability and fineness; it has, however, some disadvantages in terms of the functional and aesthetic complications of its donor site. In alternative to a radial forearm free flap, we report the use of the free super thin external pudendal artery flap (STEPA flap) for an oropharyngeal reconstruction. The aim was to decrease the donor site morbidity. A 71‐years‐old man with a T2N0M0 oropharyngeal squamous cell carcinoma has undergone surgical treatment. A left STEPA free flap was performed to reconstruct a defect about 8 × 6 cm2. This flap was designed as a half‐scrotal free flap sized 9 × 7 cm2 and was inset after tunneling of the pedicle at the floor of the mouth. A surgical revision was needed on the 15th day postoperative for disunion. There was no skin flap failure. After 12 month of follow‐up, no complication was observed at the donor site and no erectile dysfunction was recorded. Its characteristics in terms of fineness, flexibility, ease of conformation, and pedicle length are similar to those of the radial forearm flap with less aesthetic and functional sequelae of the donor site. The STEPA flap may be a promising free flap in oropharyngeal or oral cavity reconstruction.
A novel miniaturized antipodal Vivaldi antenna with high gain
Authors: Yin Zhangfei , Yang Xue‐Xia , Yu Fan , Gao Steven 
Published: September 2019

AbstractA novel antipodal Vivaldi antenna operating at an ultra‐wideband of 5.2 to 40 GHz with high gain and miniaturized size is presented in this article. By introducing a pair of radiation arms with maple‐leaf edge shape, the antenna gain is increased by 1 to 3 dB over the upper operation band (10‐40 GHz) compared to the normal antipodal Vivaldi antenna (AVA). To remain the beamwidth while increasing the gain, two rows of specialized symmetrical metallized vias are loaded on the two inside edges of the exponentially slot. By loading the resistors between the top and the bottom planes, the side lobe level at E‐plane is reduced by 3 dB. This proposed maple‐leaf antipodal Vivaldi antenna (MAVA) has the miniaturization size of 0.66λg × 0.68λg × 0.003λg. According to the simulated results, the relative bandwidth of the reflection coefficient less than −10 dB is 154%, and the gain is higher than 10 dBi over the 22 to 40 GHz band with the maximum value of 14.3 dBi. The antenna design is validated by the measurements.
Body motion detection and correction in cardiac PET: Phantom and human studies
Authors: Sun Tao , Petibon Yoann , Han Paul K. , Ma Chao , Kim Sally J. W. , Alpert Nathaniel M. , El Fakhri Georges , Ouyang Jinsong 
Published: September 2019

PurposePatient body motion during a cardiac positron emission tomography (PET) scan can severely degrade image quality. We propose and evaluate a novel method to detect, estimate, and correct body motion in cardiac PET.MethodsOur method consists of three key components: motion detection, motion estimation, and motion‐compensated image reconstruction. For motion detection, we first divide PET list‐mode data into 1‐s bins and compute the center of mass (COM) of the coincidences’ distribution in each bin. We then compute the covariance matrix within a 25‐s sliding window over the COM signals inside the window. The sum of the eigenvalues of the covariance matrix is used to separate the list‐mode data into “static” (i.e., body motion free) and “moving” (i.e. contaminated by body motion) frames. Each moving frame is further divided into a number of evenly spaced sub‐frames (referred to as “sub‐moving” frames), in which motion is assumed to be negligible. For motion estimation, we first reconstruct the data in each static and sub‐moving frame using a rapid back‐projection technique. We then select the longest static frame as the reference frame and estimate elastic motion transformations to the reference frame from all other static and sub‐moving frames using nonrigid registration. For motion‐compensated image reconstruction, we reconstruct all the list‐mode data into a single image volume in the reference frame by incorporating the estimated motion transformations in the PET system matrix. We evaluated the performance of our approach in both phantom and human studies.ResultsVisually, the motion‐corrected (MC) PET images obtained using the proposed method have better quality and fewer motion artifacts than the images reconstructed without motion correction (NMC). Quantitative analysis indicates that MC yields higher myocardium to blood pool concentration ratios. MC also yields sharper myocardium than NMC.ConclusionsThe proposed body motion correction method improves image quality of cardiac PET.
Comparison of surface guidance and target matching for image‐guided accelerated partial breast irradiation (APBI)
Authors: Zhao Hui , Williams Ned , Poppe Matthew , Sarkar Vikren , Wang Brian , Rassiah‐Szegedi Prema , Huang Y. Jessica , Kokeny Kristine , Gaffney David , Salter Bill 
Published: September 2019

PurposeWe investigate the feasibility of surface guided radiation therapy (SGRT) for accelerated partial breast irradiation (APBI) by comparing it with in‐room, fan beam kV computed tomography on rails (CTOR) imaging of the targeted region. The uniqueness of our study is that all patients have multiple daily CTOR scans to compare corresponding SGRT AlignRT (VisionRT, United Kingdom) images to.Methods/materialsTwelve patients receiving APBI were enrolled in this study. Before each treatment fraction, after patients were setup on tattoos, SGRT was performed using AlignRT, and then target matching was performance using CTOR. The average and maximum difference in shifts between SGRT and CTOR were calculated and analyzed for each patient, so as the correlation between surgical cavity size and shift difference.ResultsOur study showed that SGRT agreed well with CTOR for patients with small surgical cavity volume changes (<10%). There were nine patients who had a ≥5 mm maximum shift difference between SGRT and CTOR along any direction, and in two patients the difference was more than 10 mm (one patient with surgical cavity change 44.3% and one patient with 27 cc cavity volume decrease). All patients, except one, had a mean shift difference < 5 mm along any direction.ConclusionFor the patients studied here, SGRT appears to be a reasonable and potentially valuable image guidance approach for APBI for patients who experience small changes in surgical cavity volume (<10%) between CT simulation and treatment. However, there is potential for larger alignment errors (up to 11 mm) when using SGRT for patients who experience larger surgical cavity changes.
Immunosuppressive and immunomodulatory therapies for neuromuscular diseases. Part I: Traditional agents
Authors: Farmakidis Constantine , Dimachkie Mazen M. , Pasnoor Mamatha , Barohn Richard J. 
Published: September 2019

AbstractImmunosuppressive and immunomodulatory therapies have had a major effect on the treatment of immune‐mediated neuromuscular diseases. After the landmark introduction of synthetic corticosteroids, other therapies have become available, including plasma exchange (PLEX), immunoglobulin G (IgG), and steroid‐sparing immunosuppressive drugs. More recently, novel biologically derived and antigen‐specific pharmaceuticals have entered neuromuscular practice. Various levels of evidence guide the use of these treatments. This article reviews current immune‐based therapies in neuromuscular diseases and is divided into two parts. Part I provides an update on the evidence and use of traditional therapies, such as corticosteroids, PLEX, intravenously delivered IgG (IVIG), and steroid‐sparing immunosuppressive drugs. Part II focuses on the recently US Food and Drug Administration–approved therapies eculizumab and subcutaneous IgG (SCIG), the current indications for rituximab in neuromuscular disease, and on novel immunosuppressive therapeutic approaches under development.
On accuracy improvement of microscopic stress/stress sensitivity analysis with the mesh superposition method for heterogeneous materials considering geometrical variation of inclusions
Authors: Sakata S. , Chan Y. , Arai Y. 
Published: September 2019

SummaryIn this paper, a new method is proposed for improving accuracy of microscopic stress analysis/stress sensitivity analysis of heterogeneous materials considering a geometrical variation of inclusions using the mesh superposition method‐based approach. In particular, the analysis, which considers a location variation of inclusions in heterogeneous materials with location change of a local mesh, is a target problem. This problem must be accurately solved for, eg, reliability evaluation with the multiscale stochastic stress analysis considering a microscopic geometrical variation of composites. The influence of a geometrical random variation of inclusions on the stress field is not negligible; further, a finite element mesh must be substantially updated for the evaluation of stress field for a significant realization. Therefore, the mesh superposition method based approach is adopted. In this paper, a problem point in the stress/stress sensitivity analysis considering the geometrical variation of inclusions when using the mesh superposition method is discussed, and improved approaches based on an improved formulation and a relocalization analysis are proposed. The proposed approaches are applied to a stress/stress sensitivity analysis of a heterogeneous material associated with a microstructure of composites. With the numerical results, effectiveness of the proposed approach is discussed.