bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRTC1‐TRIM11 fusion defined melanocytic tumors: A series of four cases
Authors: Ko Jennifer S. , Wang Lin , Billings Steven D. , Pissaloux Daniel , Tirode Franck , Berry Ryan , De La Fouchardiere Arnaud 
Published: June 2019

AbstractA cutaneous melanocytic tumor with morphologic overlap with clear cell sarcoma, but defined by CRTC1‐TRIM11 gene fusion, was recently described in a series of five adult patients. Here, we expand the clinicopathologic features of this entity by four additional cases which include pediatric presentation, exophytic growth, and propensity to occur on the head. Patients (2F; 2M) had a median age of 41 years (range 11‐59). Sites of involvement included leg, ear, and face. Tumors were circumscribed, unencapsulated, mostly limited to the dermis, and varied from 5 to 35 mm. One case was exophytic. Lesional cells were arranged in nests and fascicles, and were monomorphic and fusiform with moderate pale to clear cytoplasm, occasional nuclear pseudo‐inclusions, and small to prominent nucleoli. Mitotic rate was variable (rare to 12/10 HPF, median 3/10 HPF). The pediatric case showed increased nuclear pleomorphism, tumor necrosis, and mitotic figures. All cases showed strong, diffuse nuclear staining for SOX10, but were negative or focal for S100 protein, HMB45 and Melan‐A expression. Cases were positive by FISH technique and/or RNA sequencing for a TRIM11 rearrangement/fusion, and negative for EWSR1 rearrangement. This series is presented to aid in further characterization of this novel melanocytic tumor.
Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma
Authors: Alegría‐Landa Victoria , Kutzner Heinz , Requena Luis 
Published: June 2019

AbstractCarcinosarcomas are biphasic tumors composed of admixed malignant epithelial and mesenchymal components. Numerous terms have been used to name such neoplasms; therefore, terminological confusion is frequent. Most examples of carcinosarcomas are encountered in non‐cutaneous sites, with approximately 100 cases of cutaneous carcinosarcomas reported so far in the English literature. Although different theories have been suggested to explain the occurrence of these peculiar neoplasms, histogenetic mechanisms should be better hypothesized depending on each individual case. Even though prognosis tends to be related to the specific components of the lesion, especially the epithelial one, it seems that cases of cutaneous localization usually have a better outcome. We report an exceedingly rare case of syringocystadenocarcinoma papilliferum which showed an atypical stroma with sarcomatoid appearance, and highlight that the terminology used for this spectrum of lesions is disorganized and confusing.
Comparing microbial transformation of maize residue‐N and fertilizer‐N in soil using amino sugar‐specific 15N analysis
Authors: Hu Guoqing , Zhao Yu , Liu Xiao , Zhou Feng , Zhang Wei , Shao Shuai , He Hongbo , Zhang Xudong 
Published: June 2019

AbstractIn agroecosystems, both fertilizer‐nitrogen (N) and crop residue‐N make important contributions to soil‐N retention. However, how different N sources are dynamically involved in microbial processes and how they govern soil‐N transformations is poorly understood. A field experiment with half‐yield maize residue mulching was conducted in an Alfisol. The 15N‐labelled fertilizer and maize (Zea mays L.) residue were applied in the first year and then unlabelled ones were used in the following 4 years. The origins of newly formed fungal and bacterial residues were investigated by amino sugar‐specific 15N analysis. The aim was to gain insights into the microbial transformation dynamics of fertilizer‐N and maize residue‐N, as well as the maintenance of these exogenous N sources in soil. The initial transformation of fertilizer‐N into amino sugars was much more rapid than that of maize residue‐N. However, the eventual accumulation of maize residue‐N in amino sugars was significantly greater than that of fertilizer‐N. The transformation of maize residue‐15N into amino sugars was 3.5–6.7 times higher than that of fertilizer‐15N over the course of 5 years, implying a higher immobilization of maize residue‐derived N than fertilizer‐derived N in the soil. The effective transformation of maize residue‐N into microbial residues and the low level of maize residue‐derived mineral N accumulation suggested that a direct route probably dominated the microbial process. Moreover, the maize residue‐derived fungal glucosamine was more apt to accumulate than muramic acid, compared with that derived from fertilizer, suggesting that fungi contributed more to the direct assimilation of maize residue‐derived N. Such a pattern was mostly attributed to fungal decomposition of less bioavailable components of maize residue. Thus, maize residue‐N played a significant role in building soil organic N reserves, being a sustaining foundation for the effective utilization of fertilizer‐N by crops.Highlights

Fungal and bacterial residues derived from maize residue‐N and fertilizer‐N were investigated.
Fungi dominated maize residue‐N immobilization mostly via direct route.
Maize residue‐N had higher microbial immobilization efficiency than fertilizer‐N.
Maize residue‐N contributed dominantly to the building of soil organic N pool.
Evaluation of zincated nanoclay polymer composite in releasing Zn and P and effect on soil enzyme activities in a wheat rhizosphere
Authors: Mandal Nintu , Datta Samar C. , Manjaiah Kanchikeri M. , Dwivedi Brahma S. , Kumar Rajesh , Aggarwal Pramila 
Published: June 2019

AbstractZinc deficiency in soil is a widespread global phenomenon, resulting in smaller Zn content in cereal grains, particularly in wheat. Conventional fertilizers (ZnSO4·7H2O or ZnSO4· H2O) resulted in low recovery efficiency (1–5%). An innovative fertilizer formulation was synthesized using nanoclay (having at least one dimension <100 nm), copolymer (acrylic acid and acrylamide as monomers), N,N‐Methylenebisacrylamide (NNMBA) as a crosslinking agent and ammonium persulphate (APS) as initiator. Zinc was added as Zn‐citrate during polymerization reactions. The product was named zincated nanoclay polymer composite (ZNCPC) containing 6.59% total Zn. The nanocomposite was evaluated in a laboratory incubation experiment and the data showed that it acted as a controlled release Zn formulation. Two doses of ZNCPC (5.0 mg Zn kg−1and 2.5 mg Zn kg−1) were tested in pot experiments and compared with ZnSO4·7H2O (5.0 mg Zn kg−1) in two Zn‐deficient soils (Soil I and Soil II) at the crown root initiation (CRI) and heading initiation (HI) stages in rhizosphere (with plants) and non‐rhizosphere (without plants) soil. The nanocomposite significantly increased DTPA‐extractable Zn (DTPA‐Zn), Olsen‐P and enzyme activities in rhizosphere soil. Citrate released during degradation of ZNCPC in soil solubilized native or applied P, which in turn increased Olsen‐P content in soil. Zinc content in wheat biomass at the HI stage increased to 88 and 87% in Soils I and II, respectively, compared to ZnSO4·7H2O. There were positive and significant correlations among DTPA‐Zn, Olsen‐P and soil enzyme activities across growth stages and soil types. The ZNCPC proved to be an innovative and promising fertilizer formulation in a wheat rhizosphere that needed to be evaluated in a long‐term field experiment for its benefit:cost ratio and widespread adaptability. To explore an increase in Zn use efficiency the novel ZNCPC formulation was applied in a wheat rhizosphere. As there was an increase in DTPA‐Zn, Olsen‐P and soil enzyme activities, ZNCPC proved to be an innovative promising fertilizer formulation.HighlightsTo explore an increase in Zn use efficiency.Novel ZNCPC formulation was applied in wheat rhizosphere.Increase in DTPA extractable Zn, Olsen‐P and soil enzyme activities.ZNCPC proved to be an innovative promising fertilizer formulation.
Prolonged tropical forest degradation due to compounding disturbances: Implications for CO2and H2O fluxes
Authors: Brando Paulo M. , Silvério Divino , Maracahipes‐Santos Leonardo , Oliveira‐Santos Claudinei , Levick Shaun R. , Coe Michael T. , Migliavacca Mirco , Balch Jennifer K. , Macedo Marcia N. , Nepstad Daniel C. , Maracahipes Leandro , Davidson Eric , Asner Gregory , Kolle Olaf , Trumbore Susan 
Published: June 2019

AbstractDrought, fire, and windstorms can interact to degrade tropical forests and the ecosystem services they provide, but how these forests recover after catastrophic disturbance events remains relatively unknown. Here, we analyze multi‐year measurements of vegetation dynamics and function (fluxes of CO2and H2O) in forests recovering from 7 years of controlled burns, followed by wind disturbance. Located in southeast Amazonia, the experimental forest consists of three 50‐ha plots burned annually, triennially, or not at all from 2004 to 2010. During the subsequent 6‐year recovery period, postfire tree survivorship and biomass sharply declined, with aboveground C stocks decreasing by 70%–94% along forest edges (0–200 m into the forest) and 36%–40% in the forest interior. Vegetation regrowth in the forest understory triggered partial canopy closure (70%–80%) from 2010 to 2015. The composition and spatial distribution of grasses invading degraded forest evolved rapidly, likely because of the delayed mortality. Four years after the experimental fires ended (2014), the burned plots assimilated 36% less carbon than the Control, but net CO2exchange and evapotranspiration (ET) had fully recovered 7 years after the experimental fires ended (2017). Carbon uptake recovery occurred largely in response to increased light‐use efficiency and reduced postfire respiration, whereas increased water use associated with postfire growth of new recruits and remaining trees explained the recovery in ET. Although the effects of interacting disturbances (e.g., fires, forest fragmentation, and blowdown events) on mortality and biomass persist over many years, the rapid recovery of carbon and water fluxes can help stabilize local climate.
Associations between self‐reported hearing loss and outdoor activity limitations, psychological distress and self‐reported memory loss among older people: Analysis of the 2016 Comprehensive Survey of Living Conditions in Japan
Authors: Iwagami Masao , Kobayashi Yoko , Tsukazaki Eriko , Watanabe Taeko , Sugiyama Takehiro , Wada Tetsuro , Hara Akira , Tamiya Nanako 
Published: June 2019

AimTo investigate the associations between self‐reported hearing loss and outdoor activity limitations, psychological distress and self‐reported memory loss among older people.MethodsWe carried out a cross‐sectional study using the data from the 2016 Comprehensive Survey of Living Conditions in Japan. The study population included people aged ≥65 years living at home, without a clinical diagnosis of dementia. The exposure of interest was self‐reported hearing loss, whereas outcomes included outdoor activity limitations (Yes/No), psychological distress (Kessler Psychological Distress Scale score of ≥5) and self‐reported memory loss (Yes/No). We carried out logistic regression analyses, adjusted for age, sex, smoking, alcohol, educational status, number of household members, household expenditure and number of clinical diagnoses requiring outpatient visits.ResultsAmong 137 723 older people (mean age 74.5 years [standard deviation 7.4 years], 45.1% men), 12 389 (9.0%) reported hearing loss. People with hearing loss showed a higher prevalence of outdoor activity limitations (28.9% vs 9.5%, P < 0.001), psychological distress (39.7% vs 19.3%, P < 0.001) and memory loss (37.7% vs 5.2%, P < 0.001) than those without. The adjusted odds ratios comparing people with and without hearing loss were 2.0 (95% confidence interval 1.9–2.1), 2.1 (95% confidence interval 2.0–2.1) and 7.1 (95% confidence interval 6.8–7.4) for outdoor activity limitations, psychological distress and self‐reported memory loss.ConclusionsThis nationwide study suggested that older people with hearing loss were more likely to experience outdoor activity limitations, psychological distress and memory loss than those without. Early identification of and intervention in hearing loss might potentially reduce the risk of these poor health outcomes. Geriatr Gerontol Int 2019; 19: 747–754.
High‐Precision Measurement of Stable Cr Isotopes in Geological Reference Materials by a Double‐Spike TIMS Method
Authors: Liu Chun‐Yang , Xu Li‐Juan , Liu Chun‐Tao , Liu Jia , Qin Li‐Ping , Zhang Zi‐Da , Liu Sheng‐Ao , Li Shu‐Guang 
Published: June 2019

Chromium (Cr) isotopes have been widely used in various fields of Earth and planetary sciences. However, high‐precision measurements of Cr stable isotope ratios are still challenged by difficulties in purifying Cr and organic matter interference from resin using double‐spike thermal ionisation mass spectrometry. In this study, an improved and easily operated two‐column chemical separation procedure using AG50W‐X12 (200–400 mesh) resin is introduced. This resin has a higher cross‐linking density than AG50W‐X8, and this higher density generates better separation efficiency and higher saturation. Organic matter from the resin is a common cause of inhibition of the emission of Cr during analysis by TIMS. Here, perchloric and nitric acids were utilised to eliminate organic matter interference. The Cr isotope ratios of samples with lower Cr contents could be measured precisely by TIMS. The long‐term intermediate measurement precision of δ53/52CrNIST SRM 979 for BHVO‐2 is better than ± 0.031‰ (2s) over one year. Replicated digestions and measurements of geological reference materials (OKUM, MUH‐1, JP‐1, BHVO‐1, BHVO‐2, AGV‐2 and GSP‐2) yield δ53/52CrNIST SRM 979 results ranging from −0.129‰ to −0.032‰. The Cr isotope ratios of geological reference materials are consistent with the δ53/52CrNIST SRM 979 values reported by previous studies, and the measurement uncertainty (± 0.031‰, 2s) is significantly improved.
Comparison of new prognostic systems for patients with resectable hepatocellular carcinoma: Albumin‐Bilirubin grade and Albumin‐Indocyanine Green Evaluation grade
Authors: Honmyo Naruhiko , Kobayashi Tsuyoshi , Hamaoka Michinori , Kohashi Toshihiko , Abe Tomoyuki , Oishi Koichi , Tazawa Hirofumi , Imaoka Yasuhiro , Akita Tomoyuki , Tanaka Junko , Ohdan Hideki ,   Hiroshima Surgical study group of Clinical Oncology (HiSCO)
Published: June 2019

AimWe aimed to compare the prognostic abilities of two novel liver function‐estimating models, Albumin‐Bilirubin (ALBI) and Albumin‐Indocyanine Green Evaluation (ALICE) grades, in patients with hepatocellular carcinoma.MethodsData of 1270 patients who underwent initial hepatectomy for hepatocellular carcinoma between 1986 and 2016 were retrospectively collected from a multi‐institutional database. The prognostic impact of each system was analyzed according to the results of the area under the receiver operating characteristic curve, the Cox regression model and the linear trend χ2‐test.ResultsThe ALBI and ALICE scores, which were obtained before grading status, were significantly correlated (correlation coefficient 0.930; P < 0.001). Both ALBI and ALICE grades stratified well in terms of overall survival, and were found to be independent prognostic factors on multivariate analysis (P < 0.05). The area under the receiver operating characteristic curves for 5‐year survival in both groups were equivalent (0.602 vs. 0.614, P = 0.402); however, homogeneity, discriminatory ability, and the Akaike information criterion were superior for the ALICE grade than for the ALBI grade (73.8 vs. 65.7, 43.4 vs. 34.9, and 7204.1 vs. 7212.2, respectively).ConclusionsBoth grading systems could estimate the liver function of patients with hepatocellular carcinoma. Regarding hepatectomy patients, the ALICE grade was a more suitable model than the ALBI grade.
Assessment of interatomic parameters for the reproduction of borosilicate glass structures via DFT‐GIPAW calculations
Authors: Fortino Mariagrazia , Berselli Alessandro , Stone‐Weiss Nicholas , Deng Lu , Goel Ashutosh , Du Jincheng , Pedone Alfonso 
Published: June 2019

AbstractBorates and borosilicates are potential candidates for the design and development of glass formulations with important industrial and technological applications. A major challenge that retards the pace of development of borate/borosilicate based glasses using predictive modeling is the lack of reliable computational models to predict the structure‐property relationships in these glasses over a wide compositional space. A major hindrance in this pursuit has been the complexity of boron‐oxygen bonding due to which it has been difficult to develop adequate B–O interatomic potentials. In this article, we have evaluated the performance of three B–O interatomic potential models recently developed by Bauchy et al [J. Non‐Cryst. Solids, 2018, 498, 294–304], Du et al [J. Am. Ceram. Soc. https://doi.org/10.1111/jace.16082] and Edèn et al [Phys. Chem. Chem. Phys., 2018, 20, 8192–8209] aiming to reproduce the short‐to‐medium range structures of sodium borosilicate glasses in the system 25 Na2O x B2O3 (75 − x) SiO2 (x = 0‐75 mol%). To evaluate the different force fields, we have computed at the density functional theory level the NMR parameters of 11B, 23Na, and 29Si of the models generated with the three potentials and the simulated MAS NMR spectra compared with the experimental counterparts. It was observed that the rigid ionic models proposed by Bauchy and Du can both reliably reproduce the partitioning between BO3 and BO4 species of the investigated glasses, along with the local environment around sodium in the glass structure. However, they do not accurately reproduce the second coordination sphere of silicon ions and the Si–O–T (T = Si, B) and B‐O‐T distribution angles in the investigated compositional space which strongly affect the NMR parameters and final spectral shape. On the other hand, the core‐shell parameterization model proposed by Edén underestimates the fraction of BO4 species of the glass with composition 25Na2O 18.4B2O3 56.6SiO2 but can accurately reproduce the shape of the 11B and 29Si MAS‐NMR spectra of the glasses investigations due to the narrower B–O–T and Si‐O‐T bond angle distributions. Finally, the effect of the number of boron atoms (also distinguishing the BO3 and BO4 units) in the second coordination sphere of the network former cations on the NMR parameters have been evaluated.
Stakeholder perspectives of compassion in nursing: The development of the compassion strengths model
Authors: Durkin Mark , Gurbutt Russell , Carson Jerome 
Published: June 2019

AbstractAimsTo explore stakeholder perspectives of compassion in nursing.BackgroundStudies show that nurses’ compassion can be characterized by 11 characteristics. A growing body of research illustrates how courses aimed at teaching nursing students about compassion can be effective. Including the views of key stakeholders in the design of these programmes is recommended, yet the number of studies that have explored this are limited.DesignThis study used a qualitative exploratory design, applying a directed content and thematic analysis to the data.MethodsKey stakeholders (N = 34), including nurse educators, nursing students, registered nurses and service user/patients, were recruited between September 2016 ‐ July 2017. Focus groups and semi‐structured one‐to‐one interviews were conducted. Data were transcribed verbatim. Directed content analysis and thematic analysis were applied to transcripts to address two separate research questions.ResultsIn relation to question 1, ‘What are the characteristics of a compassionate nurse’? eight themes: (a) character; (b) self‐care; (c) connection; (d) empathy; (e) interpersonal skills; (f) communication; (g) competence; and (h) engagement, emerged from the content analysis. For question 2, ‘How can compassion be taught to nursing students’? there were five separate themes that emerged from the thematic analysis: (a) beliefs about teaching compassion; (b) motivation; (c) the 5 W’s needed to teach compassion to nursing students; (d) barriers to compassion in practice; and (e) compassion requires strengthConclusionThe findings of this research support previous research into compassion in nursing. The Compassion Strengths model may serve as a framework for nursing students and nurses’ compassionate practice. This may also assist nurses internationally to develop further research in this vital area.
Comparison of four heterogeneity measures for meta‐analysis
Authors: Lin Lifeng 
Published: June 2019

AbstractRationale, aims, and objectivesHeterogeneity is a critical issue in meta‐analysis, because it implies the appropriateness of combining the collected studies and impacts the reliability of the synthesized results. The Q test is a traditional method to assess heterogeneity; however, because it does not have an intuitive interpretation for clinicians and often has low statistical power, many meta‐analysts alter to use some measures, such as the I2 statistic, to quantify the extent of heterogeneity. This article aims at providing a summary of available tools to assess heterogeneity and comparing their performance.MethodsWe reviewed four heterogeneity measures (I2,
,
, and
) and illustrated how they could be treated as test statistics like the Q statistic. These measures were compared with respect to statistical power based on simulations driven by three real‐data examples. The pairwise agreement among the four measures was also evaluated using Cohen's κ coefficient.ResultsGenerally,
was slightly more powerful than the Q test, while its type I error rate might be slightly inflated. The power of I2 was fairly close to that of Q. The
and
statistics might have low powers in some cases. Because the differences between the powers of I2,
, and Q were often tiny, meta‐analysts might not expect I2 and
to yield significant heterogeneity if the Q test failed to do so. In addition, I2 and
had fairly good agreement based on the simulated meta‐analyses, but all other pairs of heterogeneity measures generally had poor agreement.ConclusionThe I2 and
statistics are recommended for measuring heterogeneity. Meta‐analysts should use the heterogeneity measures as descriptive statistics which have intuitive interpretations from the clinical perspective, instead of determining the significance of heterogeneity simply based on their magnitudes.
Rolling circle amplification and its application in microfluidic systems for Escherichia coli O157:H7 detections
Authors: Jiang Yuqian , Li Shuying , Qiu Zhenyu , Le Tao , Zou Shan , Cao Xudong 
Published: June 2019

AbstractRolling circle amplification (RCA) has been widely used to enhance detection signals as its long single‐stranded RCA products can provide multiple binding sites for signal probes for sensitive detections. In the current study, we employ atomic force microscopy (AFM) to monitor the RCA products during the course of the RCA process over time. Subsequently, the results of the RCA obtained from the AFM study are combined with those from the conventional electrophoresis method to optimize RCA reactions for rapid and sensitive detection. We show that there appears to be an inhomogeneous RCA initiation phase in early to mid‐stage of the RCA reaction where some chains grow faster while others grow slower or remain dormant, an observation that has not been reported in the literature. Furthermore, we demonstrate that the RCA can significantly enhance detection signals by up to 100‐fold. We also show that the Escherichia coli O157:H7 detection with the RCA can be carried out in different food matrices with excellent detection sensitivities and specificities. In conclusion, these results suggest that a microfluidic device in combination with RCA signal enhancement is a simple and robust approach to sensitive whole‐cell detection in food samples.Practical applicationsThe current research has exciting potentials for applications in sensitive detections of food samples for food safety inspections.