bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revising AACSB-accredited BBA and MBA core curricula: Kotter’s 8 steps in action
Authors: McKee Rob Austin , Botsford Morgan Whitney 
Published: November 2024

Purpose
The purpose of this paper is to chronicle a major curricular change initiative involving BBA and MBA core program reviews and revisions at an Association to Advance Collegiate Schools of Business (AACSB)-accredited College of Business. The authors provide rationales for the change effort that likely mirror those of similar institutions. Kotter’s 8 steps for transforming organizations (1995) are overlaid with the sequence of actions taken by the key change agents. Several examples of specific changes are provided to illustrate how the initiative was planned and completed, aligned with Kotter’s 8 steps.

Design/methodology/approach
This paper reports a case study of action research conducted during an extensive curricular change intervention undertaken at the focal institution. It includes details regarding how key change agents collected data to support the initiative, including conducting a survey, meeting with stakeholder groups and collecting information about other institutions.

Findings
The curricular review and revision process is challenging but navigable with a clear plan. Kotter’s 8 steps provide a solid foundation for such initiatives that can be tailored to the desired outcome(s) and the context within which the change is being pursued. Key takeaways and recommendations are interwoven within the narrative, intending to guide ambitious readers through a similar curricular change process with greater efficiency and effectiveness.

Originality/value
This paper is unique in its focus on a major curricular change initiative within an AACSB-accredited College of Business. It goes a step beyond a typical narrative case study by incorporating action research grounded in Kotter’s well-supported change management paradigm. As such, this paper represents a unique contribution to the literature.
We are ready for halal tourism, aren’t we? Exploring readiness of non-Muslim perspective in Thailand
Authors: Dabamona Samsudin Arifin , Chompupor Philaiwan , Ghuangpeng Siriwan 
Published: November 2024

Purpose
The purpose of this paper is to investigate Thailand’s halal tourism concept from non-Muslim students’ perspective and explore their perceptions and awareness of local community toward Muslim tourists.

Design/methodology/approach
This study used a qualitative survey with 75 participants who were representatives of non-Muslim students majoring in tourism in their second semester at Mahasarakham University in Thailand. Constructivist grounded theory is applied inductively to data analysis, with support from NVivo software (V.12).

Findings
The findings showed that the notion of halal or halal tourism is less widely understood as a whole and, at the same time, is an expression that is less commonly used in student participants’ locations. Much of the understanding is perceived through an accidental acquisition where the concept of halal tourism or halal takes place. In addition, much focus is placed on honoring and offering additional options for those who want to experience halal tourism and equality in every religion.

Research limitations/implications
Qualitative survey adopted does not optimally capture the views of student participants. Furthermore, this research was conducted exclusively on students majoring in tourism and hospitality at Mahasarakham University in the northeastern region of Thailand. This resulted in a limited understanding of research results.

Practical implications
This study suggested the large surge in the global Muslim population demands further understanding and education regarding halal principles and Muslim tourism for the benefit of students and the tourism industry, undertaken by local academic institutions, particularly those offering tourism and hospitality programs.

Social implications
Meeting the needs of Muslim tourists does not eliminate their responsibility for the demands of adapting to cultural attributes and beliefs in the host community environment.

Originality/value
This study promotes comprehension regarding the perceptions of non-Muslim students regarding the notion of halal tourism and their preparedness to establish themselves as halal tourism destinations. In addition, it provides an overview of participants’ knowledge of the local community environment and halal tourism and contributes to the voids in halal tourism research, particularly regarding its weaknesses and challenges to the industry’s future development.
Fetal Heart Rate Analysis in Pregnancies Complicated by Gestational Diabetes Mellitus: A Prospective Multicentre Observational Study
Authors: Chivers Sian , Ovadia Caroline , Vasavan Tharni , Lucchini Maristella , Hayes‐Gill Barrie , Pini Nicolò , Fifer William Paul , Williamson Catherine 
Published: November 2024

ABSTRACTObjectiveEstablish whether pregnancies complicated by gestational diabetes mellitus (GDM) are associated with a fetal cardiac phenotype that predisposes to arrhythmia; utilising measurements derived from non‐invasive abdominal fetal ECG.DesignProspective observational study.SettingThree tertiary obstetric units, United Kingdom.PopulationWomen aged ≥ 16 years with either GDM or uncomplicated pregnancy (control) who were > 20 weeks gestational age.MethodsThe MonicaAN24 non‐invasive abdominal fetal ECG monitor was fitted for overnight recording.Main Outcome MeasureCalculation of the fetal heart rate (FHR) and fetal heart rate variability (HRV) time domain metrics standard deviation of normal‐to‐normal intervals (SDNN), root mean square of successive differences (RMSSD) and the PR, QRS, QT intervals was performed. Groups were compared using linear regression models (stratified by sleep state) and adjusted for fetal sex and ethnicity.ResultsNinety‐six participants were included. For HRV in sleep state 1F, SDNN was higher for GDM than control participants 12.56 (10.45–16.62)ms versus 8.58 (5.83–9.73)ms [p = 0.01] [median (IQR)]. There were no differences in SDNN in sleep state 2F. No differences were identified in RMSSD in either sleep states or in the cardiac time intervals. We observed a negative correlation between HRV and body mass index/HbA1c and a positive correlation between FHR and body mass index/HbA1c in sleep states 1F/2F.ConclusionsAlterations of HRV and FHR rate may be associated with a diagnosis of GDM, likely secondary to altered autonomic function in utero.
(Re)producing uneven waterscapes in South China: the materiality and spatiality of the Dongshen inter‐basin water supply project
Authors: Wang Raymond Yu 
Published: November 2024

AbstractThis paper explores the production and reproduction of changing hydrosocial dynamics in South China since the construction of the Dongshen Water Supply Project (DWSP), an inter‐basin water transfer that supplies approximately 70% to 80% of freshwater from Mainland China to the Hong Kong Special Administrative Region. Drawing on the idea of the waterscape, I conceptualise the DWSP as an embodiment of power and socio‐environmental relations, encompassing a wide array of physical objects, institutions, and agencies. I show that, on one hand, the DWSP has expanded, improved, and renewed its physical forms over the past six decades and intertwined with various institutional and administrative changes that consolidate its role. On the other hand, the materialisation of the DWSP has been associated with diverging spatial configurations in both water‐exporting and water‐receiving areas. That has exacerbated disparities in water access, conservation responsibilities, and socioeconomic opportunities, perpetuating uneven waterscapes. This historical‐material examination of the DWSP provides a nuanced understanding of how power and social relations can manifest through water and how hydraulic infrastructure is intimately linked with development, governance, and inequalities over space and time.
Optimizing Lactiplantibacillus plantarum viability in the gastrointestinal tract and its impact on gut microbiota–brain axis through zein microencapsulation
Authors: Zeng Jie , Lyu Yang , Huang Xueying , Leung Ho‐Kit , Zhao Shanting , Zhang Jianzhuo , Wang Yi , Wang David Y. 
Published: November 2024

AbstractEvidence suggests that Lactiplantibacillus plantarum (LP) can positively influence gut microbiota, subsequently affecting brain function via the gut–brain axis. However, the oral administration of LP may subject it to damage from gastric acid. To address this issue, a microencapsulation system was developed to protect LP and enhance its viability in the gastrointestinal tract. In the study, zein‐microencapsulated LP (MLP) was prepared using the phase separation method. We found that the optimal conditions to encapsulate LP (9 log CFU/mL) were a zein concentration of 10 mg/mL and a zein‐to‐bacteria mass ratio of 5:1. Scanning electron microscopy and dynamic light scattering analysis demonstrated that MLP exhibited a microstructure with an approximate diameter of 4 µm. Findings also revealed that microencapsulation markedly improved the in vitro survival rate of LP compared to free cells and allowed for controlled release. Subsequent in vivo studies in mice showed that this encapsulation not only boosted the colonization of LP but also ameliorated the imbalance of gut microbiota associated with depression. An analysis of the intestinal microbiota in mice identified 13 genera that exhibited significant shifts in abundance due to the depressive states. The administration of MLP reversed these microbial changes, underscoring its therapeutic potential. Additionally, the study examined the expression of pro‐inflammatory cytokines. The administrated MLP was found to reverse the inflammation in both the intestine and hippocampus of mice with depression. Behavioral assessments in mouse models corroborated the efficacy of MLP in preventing depression, positioning it as a promising daily supplement.
Cyclodextrin as a singular oligosaccharide: Recent advances of health benefit and in food applications
Authors: Sevim Sumeyra , Sanlier Nevin 
Published: November 2024

AbstractCyclodextrins (CDs) are cyclic oligosaccharides derived from the enzymatic degradation of starch. Their distinct molecular shape, which resembles a truncated cone with a hydrophobic interior and a hydrophilic outer surface, enables the formation of inclusion complexes via host–guest interactions. These complexes facilitate beneficial modifications such as enhancing the solubility and stabilizing unstable guest molecules. By forming inclusion complexes with bioactive components and drugs, CDs can increase the bioavailability of these compounds, providing benefits in the treatment of various diseases. Particularly, β‐CD can form complexes by trapping hydrophobic molecules such as cholesterol in its hydrophobic cavity. Moreover, CDs are considered significant soluble dietary fibers due to their resistance against human digestive enzymes and their utilization by intestinal microbiota. All these features suggest that CDs could encapsulate phospholipids and food components, potentially improving or preventing metabolic diseases such as cardiovascular diseases, diabetes, and neurological disorders by blocking the absorption of carbohydrates, fats, and cholesterol. This review seeks to investigate the clinical effects and mechanisms of action considering all their potential properties and their relevance to health by utilizing in vivo, in vitro, animal, and human studies.
Sensory and hedonic perception of meat versus ultra‐processed plant‐based meat analogs: A comparative study
Authors: Olegario Lary Souza , Zalama Laura , González‐Mohino Alberto , Joaquín Marian Faridy García , Ventanas Sonia 
Published: November 2024

AbstractNowadays, consumption habits are changing for different reasons, and animal products are being replaced by plant‐based analogs. Some of these analogs are classified as ultra‐processed foods (UPFs) according to NOVA criteria (food classification system). Within this scenario, little is known about consumers’ sensory response regarding these new products. One main challenge of plant‐based UPFs is imitating both the sensory characteristics and the hedonic experience of meat consumption. Although numerous studies explore the sensory profile of ultra‐processed vegan products, we found no comparisons between the sensory profiles of plant‐based analogs and their corresponding meat products. The present study aimed to compare the dynamic sensory profiles, specifically focusing on flavor and texture attributes, of animal‐based food (beef and chicken meat) and their corresponding commercial ultra‐processed plant‐based meat analogs (seitan and Mediterranean chick'n pieces) and to establish the adequacy of the intensity of certain sensory characteristics (attributes) and their impact on the acceptability of meat analogs. This was conducted using the time‐intensity technique with fourteen trained panelists and just about right scales with 59 consumers, evaluating the acceptability of the products with a 7‐point hedonic scale. The dynamic perception results for the analogs significantly differed from those of beef and chicken, specifically showing higher intensity in “nonmeat” attributes such as gumminess, mushroom flavor, vegetable flavor, and spiciness. The attributes that characterize the chicken analog are more suitable than the attributes that characterize seitan. The acceptability of seitan was not significantly influenced by the attribute suitability results. However, poor juiciness showed a significant penalty on its acceptance for the chicken analog. These identified differences highlight the need to evaluate and adjust the sensory characteristics of plant‐based products that attempt to imitate traditional meat products.Practical ApplicationThe time‐intensity technique was effective in identifying differences in the consumption experience between meat and the respective plant‐based analogs. Inadequate taste and texture characteristics can decrease the acceptability of the analogs. The identification of these characteristics is crucial for the food industry to understand consumer preferences regarding meat substitutes.
Ameliorative effects of Bacillus subtilis C10 on alcoholic liver injury in mice
Authors: Wang Qingyun , Wang Meiting , Chen Jihong , Zhang Wen , Lv Xucong 
Published: November 2024

AbstractBacillus subtilis has been reported to maintain the homeostasis of intestinal flora. In this study, a mouse model of alcoholic liver injury (ALI) was constructed to study the ameliorative effect of B. subtilis C10 on ALI and to further clarify its mechanism of action. Significant correlations between intestinal flora and biochemical indicators of ALI were found by statistical correlation analysis. Supplementation with B. subtilis C10 modulated the equilibrium of gut flora by reducing the population of detrimental bacteria while enhancing the numbers of beneficial microorganisms, which resulted in an improvement in lipid metabolism and oxidative stress in the liver. The results of RT‐qPCR showed that B. subtilis C10 intervention regulated the main regulatory factors of liver lipid metabolism (PPAR‐α, SREBP‐1c) and interfered with Nrf‐2/Ho‐1 signal pathway, which in turn ameliorated alcohol‐induced lipid metabolism disorder and liver peroxidation stress. In addition, liver metabonomic analysis showed that B. subtilis C10 intervention reduced the production of harmful metabolites and increased beneficial metabolites in the liver, thereby reversing the metabolic disturbances caused by excessive alcohol consumption. KEGG analysis showed that B. subtilis C10 intervention modulated liver metabolic disorders and accelerated lipid metabolism by regulating glutathione metabolic pathway, purine metabolic pathway, pantothenic acid and CoA biosynthesis pathway, ABC transporter protein pathway, and HIF‐1 signaling pathway. Taken together, these findings suggest that B. subtilis C10 ameliorates ALI by modifying the structure of intestinal flora and liver metabolic pathways to attenuate alcohol‐exposure‐induced liver oxidative damage and lipid metabolism abnormalities.Practical ApplicationBacillus subtilis C10 is an effective probiotic intervention that significantly ameliorated alcoholic liver injury in mice through the gut–liver axis. B. subtilis C10 can be used as a dietary probiotic to develop functional foods with beneficial effects for the population of excessive alcohol consumption.
USP5‐dependent HDAC1 promotes cisplatin resistance and the malignant progression of non–small cell lung cancer by regulating RILP acetylation levels
Authors: Lu Rongguo , Jin Yulin , Zheng Mingfeng 
Published: November 2024

AbstractBackgroundNon‐small cell lung cancer (NSCLC) is a leading cause of cancer‐related deaths worldwide, with cisplatin (DDP) resistance being a significant challenge in its treatment. Histone deacetylase 1 (HDAC1) has been implicated in the regulation of NSCLC progression; however, its role in the resistance of NSCLC to DDP remains unclear.MethodsThe mRNA levels of HDAC1, ubiquitin specific peptidase 5 (USP5), and Rab interacting lysosomal protein (RILP) were analyzed by quantitative real‐time polymerase chain reaction. The protein expression of HDAC1, multidrug resistance protein 1 (MRP1) and RILP was detected by western blotting assay or immunohistochemistry assay. The IC50 value of DDP was determined using a cell counting kit‐8 assay, while cell proliferation, apoptosis, and invasion were assessed using 5‐Ethynyl‐2’‐deoxyuridine assay, flow cytometry, and trans well invasion assay, respectively. Cancer stem‐like cell properties were analyzed by a sphere formation assay. The interaction between USP5 andHDAC1 was investigated using MG132 assay and co‐immunoprecipitation (Co‐IP).RILP acetylation was analyzed by a Co‐IP assay. A xenograft mouse model assay was employed to study the in vivo effects of HDAC1 silencing on DDP sensitivity.ResultsHDAC1 expression was upregulated in DDP‐resistant NSCLC tissues and cells. Silencing HDAC1 enhanced the sensitivity of NSCLC cells to DDP, inhibited cell proliferation, invasion, and the formation of microspheres and induced cell apoptosis. USP5 was found to deubiquitinate and stabilize HDAC1 in DDP‐resistant NSCLC cells. Moreover, HDAC1 overexpression reversed the effects induced by USP5 silencing. HDAC1 also sensitized Rab‐interacting lysosomal protein (RILP) acetylation in DDP‐resistant NSCLC cells, and RILP upregulation counteracted the effects of HDAC1 overexpression in DDP‐resistant NSCLC cells. HDAC1 silencing also improved the sensitivity of tumors to DDP in vivo.ConclusionUSP5‐dependentstabilization of HDAC1 contributed to cisplatin resistance and the malignancy of NSCLC by diminishing the levels of RILP acetylation, which suggested that targeting the HDAC1‐USP5axis might represent a novel therapeutic strategy for overcoming DDP resistance in NSCLC patients.
Comparison of venous and calculated blood gas values to arterial values in critically ill patients
Authors: Lumholdt Mads , Andreasen Jo Bønding , Damgaard Kjeld , Christensen Erika Frischknecht , Leutscher Peter Derek Christian , Rasmussen Bodil Steen 
Published: November 2024

AbstractBackgroundArterial blood gas (ABG) values are important in the assessment of critically ill patients. However, arterial puncture may be challenging to perform in these patients. The venous‐to‐arterial conversion method (v‐TAC) is used to convert venous blood gas values to calculated values meant to resemble arterial values. Calculated pH and partial pressure of carbon dioxide (PCO2) values have shown good agreement with arterial values in stable patients, but performance of the method in patients with severe acid–base disturbances is unknown. We aim to evaluate venous and calculated blood gas value congruency with arterial values in critically ill patients.MethodsCritically ill adult patients with abnormal arterial pH (<7.35 or >7.45) admitted to an intensive care unit were included in this study. Patients were divided in groups based on arterial pH (alkalemia, moderate acidaemia and severe acidaemia). ABG samples were obtained from arterial catheters and venous samples simultaneously from peripheral or central venous catheters. Venous blood gas values were converted to calculated values using the v‐TAC software. Both venous and calculated values of pH, PCO2 and partial pressure of oxygen (PO2) were compared to arterial values in scatterplots and using the Spearman's Rank Correlation.ResultsArterial and venous sample pairs were obtained from 28 patients, and 24 venous values were converted using the v‐TAC method. Scatterplots showed similar congruency of venous and calculated pH and PCO2 values to arterial values. However, one patient in the severe acidaemia group had arterial pH 7.07 and venous pH 7.04, but calculated pH 7.42. Spearman's Rank Correlation rho showed no correlation of venous and calculated PO2 values compared to arterial values (p = .989 and p = .361).ConclusionVenous and calculated pH and PCO2 values showed similar congruency with arterial values in patients with alkalemia and moderate acidaemia, while the method was unreliable in a patient suspected of severe metabolic acidaemia.
IL‐17 Producing T to Foxp3+CD4+ Regulatory T Cell Ratio as a Diagnostic and Prognostic Marker in Women With Recurrent Pregnancy Loss and Its Implications for Intravenous Immunoglobulin Therapy
Authors: Park Jin‐Sol , Song Ah‐Yun , Bae Ju‐Young , Han Jae Won , Kim Tae Hyun , Kim Chul‐Jung , Lee Sung Ki 
Published: November 2024

ABSTRACTProblemThe imbalance in the Th17/Regulatory T (Treg) cell ratio is associated with recurrent pregnancy loss (RPL). This study aimed to determine a cut‐off for the Th17/Treg cell ratio to predict pregnancy outcomes in RPL and evaluate the effectiveness of intravenous immunoglobulin (IVIG) based on this cut‐off value.Method of StudyThis retrospective cohort study included 49 idiopathic RPL and 75 controls. The subgroups of IL‐17+ T cell to Foxp3+ T cell ratios in peripheral blood were measured using flow cytometry. The cut‐off values of Th17/Treg cell ratios were determined by the ROC curve to distinguish between RPL and controls. The IVIG treatment effectiveness in pregnancy outcome was compared between high‐ and low‐ratio groups. Pearson correlation assessed the Th17/Treg cell ratio's relationship with NK cell cytotoxicity (NKC), NK cell percentage, and Th1/Th2 cell ratio.ResultsUsing the ROC curve, we identified six Th17/Treg cell ratio markers with diagnostic value, and the following two, CD3+IL‐17+ T cell/CD3+Foxp3high T cell ratio (sensitivity at 97%) and CD4+IL‐17+ T cell/CD3+Foxp3high T cell ratio (specificity at 93.61%), showed the highest statistical significance in diagnosing idiopathic RPL. Among the six diagnostic markers, in terms of predicting pregnancy outcomes with IVIG treatment, CD3+IL‐17+ T cell/CD4+Foxp3+ T cell ratio was the most valuable prognostic marker. In RPL women with high CD3+IL‐17+ T cell/CD4+Foxp3+ T cell ratio (≥ 1.096), the live birth rate (LBR) was improved with IVIG treatment. (IVIG treatment, 78.57% vs. no IVIG, 28.57%, p = 0.026). On the other hand, RPL women with low CD3+IL‐17+ T cell/CD4+Foxp3+ T cell ratio did not demonstrate the effectiveness of IVIG (LBRs with IVIG treatment, 50.00% vs. no IVIG, 84.62%, p = 0.219). In a correlation study, the CD3+IL‐17+ T cell/CD4+Foxp3+ T cell ratio was an independent prognostic marker, showing no correlation with NKC, NK cell percentage, and Th1/Th2 cell ratio.ConclusionThe CD3+IL‐17+ T/CD4+Foxp3+ T cell ratio may serve as a valuable marker for understanding the pathogenesis of RPL, predicting pregnancy outcomes, and selecting candidates for immunotherapy. Our study demonstrates that IVIG treatment can significantly improve LBR in women with a high CD3+IL‐17+ T/CD4+Foxp3+ T ratio, offering a promising therapeutic approach for this challenging condition.