bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA07: Systemic regulation of breast cancer progression
Authors: McAllister Sandra S. 
Published: May 2019

Abstract
Recurrent disease affects approximately 30% of breast cancer patients but, unfortunately, by the time overt metastases are detected, it is no longer possible to treat breast cancer patients with curative intent. Clinical evidence indicates that in women who are diagnosed with metastatic breast cancer, tumor cells disseminate from the primary tumor prior to surgical resection but can remain indolent for varying periods of time before the patient becomes symptomatic. The reasons why certain disseminated cells remain indolent while others erupt into malignant tumors remain unknown; it is therefore currently difficult to predict with any degree of accuracy which patients will experience disease relapse.
Our lab uses various mouse and xenograft models of breast cancer progression to study the early phases of metastatic disease when patients harbor indolent disseminated tumor cells in the periphery at the time of their primary diagnosis. Using triple-negative models, we previously showed that certain tumor systemically support the outgrowth of distant, otherwise indolent disseminated tumors, doing so by secreting cytokines into the host circulation and activating bone marrow hematopoietic cells to become pro-tumorigenic (McAllister, et al., Cell, 2008; Elkabets, et al., JCI, 2011; Castano, et al, Ca Disc, 2013). Using models of luminal breast cancer, we discovered that certain tumors promote the outgrowth of distant tumors by supporting angiogenesis (Kuznetsov, et al., Ca Disc, 2012).
More recently, we have begun to identify the properties of disseminated tumor cells that are poised to respond to systemic factors and importantly, the phenotype of those that do not respond to systemic regulation. We have learned that certain systemic factors (cytokines and hematopoietic cells) elicited by primary breast tumors can sustain tumor-initiating properties of disseminated cells.
Our findings highlight the systemic environment as an important component of disease progression that can be exploited to more accurately identify patients who would benefit from neoadjuvant or adjuvant therapy. Moreover, we hope that this work will pave the way to designing new therapies that can be delivered at a time when what has previously been an inexorable progression to terminal metastatic disease may be prevented.
Citation Format: Sandra S. McAllister. Systemic regulation of breast cancer progression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA07.
Abstract IA21: An integrated genome-wide systems genetics screen for breast cancer metastasis susceptibility genes
Authors: Hunter Kent W. , Bai Ling , Yang Howard H. , Hu Ying , Shukla Anjali , Ha Ngoc-Han , Doran Anthony , Faraji Farhoud , Goldberger Natalie , Lee Maxwell P. , Keane Thomas 
Published: May 2019

Abstract
Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Hundreds or thousands of genes are thought to be associated with metastasis however how many of these genes contribute etiologically to tumor progression is not currently known. Identification of the genes contributing mechanistically to the metastatic processes will not only deepen our understanding of how metastases occur, but also provide novel targets for either preventing their formation or combatting their life-threatening effects. Previously our laboratory demonstrated that inbred mice of distinct phylogenetic lineages possess distinct propensity for metastatic disease, indicating that inherited susceptibility for metastasis exists and that polymorphisms can both mark and functionally effect genes within the metastatic cascade. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways which implicates a number of transcriptional regulators and suggests cell-mediated immunity is an important determinant. The strategy described integrates meiotic genetic screens with epigenetic control of gene expression and three dimensional chromatin structure analyses to identify genes, molecular and cellular pathways likely to be important in metastatic disease. Moreover, the analysis identified novel or FDA-approved drugs as potentially useful for anti-metastatic therapy. Further explorations implementing this strategy may therefore provide a variety of information for clinical applications in the control and treatment of advanced neoplastic disease.
Citation Format: Kent W. Hunter, Ling Bai, Howard H. Yang, Ying Hu, Anjali Shukla, Ngoc-Han Ha, Anthony Doran, Farhoud Faraji, Natalie Goldberger, Maxwell P. Lee, Thomas Keane. An integrated genome-wide systems genetics screen for breast cancer metastasis susceptibility genes. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA21.
Abstract IA22: CYP3A5 mediates resistance to small molecule inhibitors in a subtype of pancreatic ductal adenocarcinoma
Authors: Noll Elisa M. , Noll Elisa M. , Eisen Christian , Eisen Christian , Espinet Elisa , Espinet Elisa , Stenzinger Albrecht , Weichert Wilko , Sprick Martin R. , Trumpp Andreas , Trumpp Andreas 
Published: May 2019

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is clinically still treated as a single disease. We have generated patient-derived models representing the recently identified quasi-mesenchymal, classical and exocrine-like PDAC subtypes, and report a two-marker set facilitating patient stratification by immunohistochemistry. The subtypes show significant differences in overall survival and drug sensitivity, with the exocrine-like subtype being resistant to the tyrosine kinase inhibitors erlotinib, dasatinib, as well as the chemotherapeutic paclitaxel. Highly expressed cytochrome P450 3A5 (CYP3A5) actively metabolizes these compounds in the exocrine-like subtype, and pharmacological or shRNA-mediated CYP3A5 inhibition sensitizes tumor cells in vivo. Additionally, we investigated the transcriptional network underlying the subtype-specific CYP3A5 expression. Hence, these data show that exocrine-like PDAC adopts a highly effective detoxification mechanism akin to that of hepatocytes. High expression of CYP3A5 in other tumor entities suggests this pathway as an important target to overcome drug resistance and to predict response to therapy with small molecule drugs.
Citation Format: Elisa M. Noll, Elisa M. Noll, Christian Eisen, Christian Eisen, Elisa Espinet, Elisa Espinet, Albrecht Stenzinger, Wilko Weichert, Martin R. Sprick, Andreas Trumpp, Andreas Trumpp. CYP3A5 mediates resistance to small molecule inhibitors in a subtype of pancreatic ductal adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA22.
Abstract PR04: Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response
Authors: Dondossola Eleonora , Alexander Stephanie , Alexander Steve , Holzapfel Boris , Logothetis Christopher , Hutmacher Dietmar , Friedl Peter 
Published: May 2019

Abstract
Bone metastases are the initial site of progression and account for many of the complications experienced by men with metastatic prostate cancer (PCa), including therapy resistance. Besides cell intrinsic mechanisms, the interaction between PCa cells and the bone microenvironment critically contributes to lesion expansion and drug sensitivity. We here developed a mouse model amenable to intravital multiphoton microscopy (iMPM) to longitudinally study PCa-stromal cell interactions and therapy response in a partially humanized neobone, established in the dermis of the mouse. Tissue engineered bone constructs, TEBCs, were generated by functionalizing polymeric polycaprolactone scaffolds with human mesenchymal stem cells (hMSCs) differentiated to osteoblasts followed by cell-derived calcification of the inter-scaffold space. 30 days after implantation of functionalized scaffolds under the skin of the mouse, bone and bone marrow maturation resulted in a 30mm3 cavity surrounded by optically transparent cortical bone of 50-60 μm thickness, as monitored by microCT and iMPM. Intra-bone tumor growth and osteolysis caused by human fluorescent PCa cells (PC3) were three-dimensionally reconstructed by multi-parameter detection through a body window, including collagen and bone matrix (SHG), calcified bone (fluorescent bisphosphonates), osteoclasts (cathepsin K), bone surface (THG), blood vessels and stromal phagocytes (fluorescent dextran), and PC3 cells (nuclear H2B/eGFP, cytoplasmatic DsRed2). As a proof of concept, the efficacy to halt bone remodeling during bisphosphonate therapy was detected, revealing the composition and kinetics of the bone-tumor interface, including oscillating bone loss followed by neo-apposition. Thus, combining engineered neobone with an optical window is suited to detail the 3D organization and dynamics of cancer lesions in bone and provides mechanistic insight and efficacy predictions for therapy response.
Citation Format: Eleonora Dondossola, Stephanie Alexander, Steve Alexander, Boris Holzapfel, Christopher Logothetis, Dietmar Hutmacher, Peter Friedl. Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr PR04.
Biocontrol properties of some agricultural waste extracts on three nematode species in in vitro and in vivo conditions
Authors: Roshan-Bakhsh Ali , Pourjam Ebrahim , Ayyari Mahdi , Pedram Majid 
Published: May 2019

Summary
Extracts of nine agricultural wastes prepared with five different solvents were assessed for their potential nematicidal activity against three nematode species, Aphelenchus avenae, Meloidogyne incognita and Pratylenchus neglectus, in in vitro condition. The 50% v/v hydro-ethanolic extracts showed the highest performance for two tested plant wastes of cabbage leaves and faba bean pods. These two extracts were tested on nematodes in three different concentrations. The highest in vitro nematistatic activity was recorded for 3000 and 1500 ppm of cabbage leaf extracts by 100% paralysis of all three nematode species after 48 h, and the highest nematicidal activity was recorded for the above-mentioned extract by 25-100% mortality depending on nematode species and extract concentration. A 14-94% mortality was recorded for all three species of nematodes after treatment with faba bean pod hydro-ethanolic extract in in vitro conditions. Hatching inhibition and repellent activity of cabbage leaf and faba bean pod extracts were observed in P. neglectus and M. incognita. In vivo assays confirmed the in vitro results when both of the extracts showed moderate to high inhibition of nematode population development and nematode infection parameters on tomato root system in pot experiments.
Interpretation of the Meaning of ‘Direct Effect’ in the Revised Treaty of Basseterre
Authors: Phillips Zachary Allen Roy 
Published: May 2019

Abstract
The article utilises the Vienna Convention on the Law of Treaties (VCLT) rules of interpretation to determine the meaning of ‘direct effect’ within the Revised Treaty of Basseterre (RTB). The RTB is the constituent treaty of the Organisation of Eastern Caribbean States (OECS). Despite the RTB having been in force since 2011 there has not been a single contentious case regarding the interpretation of the RTB. While the RTB and the OECS gained some inspiration from the European Union (EU), the Commonwealth Caribbean adheres to the dualist doctrine in the practical relationship between international and domestic law. As such, the meaning of ‘direct effect’ has been the subject of controversy. Therefore, this article shall discern the meaning of ‘direct effect’ within the RTB, including delineating possible practical application. The evaluation shall reveal that the definition is the same, however, due to the Caribbean context the application differs in slight ways.
Fecal Microbiota Transplant for Irritable Bowel Syndrome: Panacea or Placebo?
Authors: Shaukat Aasma , Brenner Darren M. 
Published: May 2019

Abstract
Irritable bowel syndrome (IBS) is a common disorder of heterogeneous pathogenesis, and alterations in the gut microbiome/dysbiosis play a role in the development of symptoms in a subset of individuals with IBS. Consequently, it stands to reason that modulation of the microbiome via fecal microbial transplant (FMT) may serve as an effective treatment strategy because this has proven effective for treating other illnesses such as Clostridium difficile colitis. Small studies completed to date have offered conflicting results and the strains used, route of administration, and IBS subtypes may all play a role in treatment outcomes. A better understanding of the altered microbiome of patients with IBS and more rigorous trials are warranted before the utility of fecal microbial transplant for IBS symptoms can be determined.
Trading on the Unknown: Scenarios for the Future Value of Data
Authors: Newlands Gemma , Lutz Christoph , Fieseler Christian 
Published: May 2019

Abstract
In this Article, we explore the practices of extensive data collection among sharing economy platforms, highlighting how the unknown future value of big data creates an ethical problem for a fair exchange relationship between companies and users. Specifically, we present a typology with four scenarios related to the future value of data. In the remainder of the Article, we first describe the status quo of data collection practices in the sharing economy, followed by a discussion of the value-generating affordances of big data. We then introduce the typology of four scenarios for the future value of data. Finally, the paper concludes with a short discussion on the implications of information asymmetries for a fair exchange process.
The Role of Platforms in Fulfilling the Potential of Crowdfunding as an Alternative Decentralized Arena for Cultural Financing
Authors: Davidson Roei 
Published: May 2019

Abstract
This study considers cultural crowdfunding as a heterogeneous system that allows money and attention to flow from backers to founders of cultural projects in diverse cultural sectors and focuses on the nature of the standards governing it. It analyzes Kickstarter’s corporate blog since the platform’s launch and finds indications that social media practices are increasingly naturalized as integral to crowdfunding and that social media architectures are increasingly adopted by the crowdfunding platform. This, I argue, has a potential exclusionary effect. At the same time, the analysis finds evidence that Kickstarter is striving to develop an independent capacity to set aesthetic standards, which might moderate that effect and help constitute crowdfunding as an alternative decentralized arena for the funding of culture.
Silos and First Movers in the Sharing Economy Debates
Authors: Ring Diane M. 
Published: May 2019

Abstract
Over the past few years, a significant global debate has developed over the classification of workers in the sharing economy either as independent contractors or as employees. While Uber and Lyft have dominated the spotlight lately, the worker classification debates extend beyond ridesharing companies and affect workers across a variety of sectors. Classification of a worker as an employee, rather than an independent contractor, can carry a range of implications for worker treatment and protections under labor law, anti-discrimination law, tort law, and tax law, depending on the legal jurisdiction. The debates, at least in the United States, have been incomplete due to the failure of policy makers and advocates to consider the scope and interconnectedness of the worker classification issues across the full sweep of legal arenas. There is time, however, to remedy the incompleteness of these policy conversations before worker classification decisions ossify and path dependence takes hold.
Two interacting forces create the most serious risk for inadequate policy formulation: (1) silos among legal experts, and (2) first-mover effects. Both of these factors, silo and first mover, emerge in sharing economy debates in the United States. Tax experts and other legal specialists operate in distinct silos leading to a misunderstanding by non-tax analysts of the tax ramifications of worker classification, and to an under appreciation on the part of tax experts of the potential influence of “modest” tax rule changes on worker classification generally. The risks of such misunderstandings can be amplified by first-mover efforts, such as: (1) platforms’ contractual designation of workers as independent contractors to bolster a claim of nonemployer/nonemployee status; (2) platforms’ support for proposed tax legislation that would “clarify” the status of sharing workers as independent contractors for tax purposes if they satisfy a multiple-prong (relatively easy) safe harbor test; and (3) sharing economy worker litigation to secure employee status.
This Article identifies the incompleteness in the worker classification debates and argues for the active formulation of policy through a process that looks beyond individual fields. A more complete conversation requires analytical engagement across multiple fields and recognition of the de facto power of reform in one arena to influence others. Moreover, it is by no means clear that just because tax might arrive at the legislative drawing table first (due to first mover effects), that it should drive or shape the broader worker classification debate.
Stochastic partial functional integrodifferential equations driven by a sub-fractional Brownian motion, existence and asymptotic behavior
Authors: Allognissode Fulbert Kuessi , Diop Mamadou Abdoul , Ezzinbi Khalil , Ogouyandjou Carlos 
Published: May 2019

Abstract
This paper deals with the existence and uniqueness of mild solutions to stochastic partial functional integro-differential equations driven by a sub-fractional Brownian motion

S
Q
H

⁢

(
t
)

{S_{Q}^{H}(t)}

, with Hurst parameter

H
∈

(

1
2

,
1
)

{H\in(\frac{1}{2},1)}

. By the theory of resolvent operator developed by R. Grimmer (1982) to establish the existence of mild solutions, we give sufficient conditions ensuring the existence, uniqueness and the asymptotic behavior of the mild solutions. An example is provided to illustrate the theory.
A Grid-Connected, PV-Interfaced Inverter with Coupled Inductor–Based Dual Input 3P3L-ZSI
Authors: Deepika S. , Venkatramanan C. B. 
Published: May 2019

Abstract
This article presents a dual-input impedance network derived three-phase three-level (3P3L) Z-source inverter (ZSI)–based inverter to transfer the power generated on the photovoltaic (PV) system to grid. The PV power generation system has become a most popular renewable power generation system because of the abundant availability of solar energy and the growth of the modern power electronics converters. The ZSI provides single-stage power conversion for dc–ac conversion with a regulated voltage at the output. The proposed inverter is constructed with an Inductor-Capacitor-Capacitor-Transformer (LCCT)-derived impedance network to extend the voltage boosting gain and efficiency with small duty ratio. The boosting gain, efficiency, and power transfer capability of the proposed topology are demonstrated by several case studies. The experimental results of the proposed 3P3L-ZSI–based inverter with dual-input voltage source are presented to validate the simulated results.
Systemic Vasculitis: An Important and Underestimated Cause of Malignant Hypertension
Authors: Zhu Qing , Liu Shasha , Heizhati Mulalibieke , Yao Xiaoguang , Wang Menghui , Luo Qin , Wang Lei , Zhang Delian , Chang Guijuan , Li Nanfang 
Published: May 2019

Objectives:Malignant hypertension (MHT) is defined as severe hypertension accompanied by ischemic failure of one or more organs. The aims of this study were to evaluate the current clinical and etiologic profiles of MHT.Methods:As a retrospective study, we selected all patients admitted to our center from January 2013 to December 2016. Seventy patients with MHT were included.Results:The average age of the patients was 40 years, and more than half of the patients were male (78.57%). There were 24 patients with essential hypertension, accounting for 34.29% of the patients, and 46 with secondary hypertension, accounting for 65.71% of the patients. For secondary MHT, systemic vasculitis (25.57%) was the most common cause, followed by severe obstructive sleep apnea syndrome (15.71%), primary renal parenchymal hypertension (11.43%), primary aldosteronism (7.14%), and Cushing syndrome (1.43%) and nutcracker phenomenon (1.43%). Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing severity. The levels of white blood cells, hypersensitive C-reactive protein, serum creatinine, and 24-hour urinary protein were above their normal range.Conclusion:Systemic vasculitis may be one of the main causes of MHT, and has been underestimated in the past. In future clinical work, clinicians need to pay more attention to patients with systemic vasculitis.
Synthetic Physical Interactions with the Yeast Centrosome
Authors: Howell Rowan S M , Csikász-Nagy Attila , Thorpe Peter H 
Published: May 2019

AbstractThe yeast centrosome or Spindle Pole Body (SPB) is an organelle situated in the nuclear membrane, where it nucleates spindle microtubules and acts as a signaling hub. Various studies have explored the effects of forcing individual proteins to interact with the yeast SPB, however no systematic study has been performed. We used synthetic physical interactions to detect proteins that inhibit growth when forced to associate with the SPB. We found the SPB to be especially sensitive to relocalization, necessitating a novel data analysis approach. This novel analysis of SPI screening data shows that regions of the cell are locally more sensitive to forced relocalization than previously thought. Furthermore, we found a set of associations that result in elevated SPB number and, in some cases, multi-polar spindles. Since hyper-proliferation of centrosomes is a hallmark of cancer cells, these associations point the way for the use of yeast models in the study of spindle formation and chromosome segregation in cancer.
Recomendaciones para obtener resultados confiables de resistencia de cilindros de concreto.
Authors: González Beltrán Guillermo , Monge Sandí Anna 
Published: May 2019

A continuación se presenta una serie de recomendaciones para asegurar la confiabilidad de los resultados de resistencia de concreto muestreado en obra. Se describe cada uno de los pasos para lograr ese objetivo. Estos son: muestreo, moldeo, curado, protección y falla. Las recomendaciones brindadas se basan en un estudio profundo de las prácticas y normas así como en la experiencia adquirida en el proceso de falla de cilindros de concreto en el Lanamme UCR. Este artículo está dirigido principalmente a los laboratorios de ensayo que ejecutan muestreos y pruebas de concreto pero también a los ingenieros y profesionales que trabajan en la construcción de obras civiles.