bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI without contrast enhancement is a highly accurate method of imaging insulinoma
Authors: Yukina M. Yu. , Troshina E. A. , Nuralieva N. F. , Tarbaeva N. V. , Rebrova O. Yu. , Mokrysheva N. G. 
Published: December 2024

BACKGROUND: According to the literature, there are contradictory results regarding the diagnostic accuracy of magnetic resonance imaging (MRI) without contrast enhancement (CE) in insulinoma, and studies that analyze the factors influencing the obtaining of false negative results have not been described.AIM: Evaluation of the operational characteristics of MRI imaging of insulinoma without CE.MATERIALS AND METHODS: Imaging studies of the abdominal cavity and retroperitoneal space were performed in patients with suspected nondiabetic hypoglycemia (NDH): MRI without CE (index test) and CT with CE (first row reference test). Ultrasound examination was used as a reference test of the second row, and arteriostimulated venous blood sampling was used in the third row. The diagnosis of NDH and insulinoma was established based on the detection of hyperinsulinemic hypoglycemia during laboratory examination and confirmation of the presence of a pancreatic tumor.RESULTS: 125 patients with insulinoma and 55 patients with other causes of NDH were included. The sensitivity of MRI without CE in the diagnosis of insulinoma was 94%, 95% CI [89%; 98%], specificity — 98%, 95% CI [90%; 100%], prognostic value of a positive result — 99%, 95% CI [95%; 100%], prognostic value of a negative result is 87%, 95% CI [76%; 94%]. The Kappa index of agreement with the final diagnosis was 0.886 (95% CI [0.814; 0.958]), which corresponds to excellent agreement, with CT — 0.750 (95% CI [0.651; 0.850]), which corresponds to significant agreement.In a comparative analysis of the tomographic and pathomorphological characteristics of insulinoma, in cases with divergent results when using MRI without CE and CT with CE, significant differences in structure, shape, contour features, localization and degree of malignancy of the tumor, as well as the structure of its surrounding parenchyma were not revealed.In the presented sample, the insulinoma has a median size of 14–15 mm with the median optical density in the native phase of CT 42–44 units.H, hyperintensivity on T2-weighted MRI images in 89%, 95% CI [78%; 95%] cases and low Grade 1 malignancy in 70%, 95% CI [56%; 81%] cases.CONCLUSION: CT with CE and MRI without CE are characterized by significant agreement in the diagnosis of insulinoma. In this regard, as well as due to the lack of radiation exposure and the strict need for contrast agents, MRI without CE can be recommended as a first-line method on a par with abdominal ultrasound and CT with CE to detect insulinoma.
Exploring the wound healing potential of Ixora coccinea and Rhododendron arboreum formulation: integrating experimental and computational approaches
Authors: Bharathy Pavithra , Thanikachalam Punniyakoti Veeraveedu , Moses Allen Christopher , Balakrishnan Dinesh Kumar 
Published: December 2024

Abstract

Background
Wound healing is a complex biological process involving numerous cellular and molecular events. Ixora coccinea and Rhododendron arboreum flowers have been traditionally used for their medicinal properties, prompting an investigation into their combined effects on wound healing using both in vitro and in silico approaches.

Methods

Ixora and Rhododendron flowers were processed in a 1:1 ratio using an ethanolic solvent. Various concentrations of the extracts were applied to wounded mouse fibroblast cell monolayers (3T3-L1). Antioxidant potential was evaluated by DPPH and H2O2 assays, while anti-inflammatory effects were assessed using BSA and EA assays. Wound closure kinetics were monitored with image analysis software. Molecular docking studies examined interactions between active compounds and essential wound-healing proteins.

Results
The formulations inhibited ROS production at a low concentration (IC50∼1.38 μg/mL), indicating suitability for managing oxidative stress. The extracts also showed protein denaturation inhibition with an IC50 value of 14.5 μg/mL for BSA and 8.3 μg/mL for EA. In vitro, the combined extracts significantly enhanced wound closure compared to control groups, with higher concentrations (40 μg/mL) accelerating closure rates (99.66 %). Molecular docking revealed interactions between key compounds (Quercetin, Rutin) and essential wound healing proteins (MMP9, TGFβ1, IGFR), suggesting mechanisms underlying their therapeutic effects.

Conclusion

In vitro and in silico findings suggest that Ixora and Rhododendron flower extracts promote wound closure and their interaction with key proteins in wound healing pathways, highlighting their potential therapeutic value.
Effect of TMAB and ZrC concentration on mechanical and morphological properties of Ni–B/ZrC composite electrodeposition
Authors: Hukumdar Omer , Kumlu Umut , Keskin Ali , Akar Mustafa A. 
Published: December 2024

Abstract
Coating of metal or nonmetallic materials made conductive can be achieved by electrodeposition method. Metals with low conductivity and cost, such as copper or steel, can be coated with materials with higher hardness, corrosion, and wear resistance, such as nickel and boron, and can meet the relevant requirements according to their usage areas. In this study, the impact of trimethylamine borane complex (TMAB) and zirconium carbide (ZrC) contents added to the bath concentrate in the Ni–B/ZrC composite coating applied on copper on the surface properties of electroplating was investigated. Electroplated specimens were examined with regard to mechanical, morphological, and corrosion resistance. The highest microhardness value was obtained in the coatings obtained with 6 g L−1 TMAB and 4 g L−1 ZrC bath concentration, and this value was found to be 1,020.4 H V. When examined in terms of coating morphology, it was seen that as the amount of TMAB increased, the ZrC content decreased over time. In the nanocomposite coating with 4 g L−1 ZrC concentration, which showed the best corrosion performance, the corrosion current decreased by 70 % compared to the Ni–B alloy.
Valuation of forward start option with mean reverting stock model for uncertain markets
Authors: Khan Muhammad Shoaib , Hussain Javed , Saeed Tareq 
Published: December 2024

Abstract
A forward start option is an exotic option with delayed activation and reduced premium that allows investors to avail market opportunities in the future. Moreover, mean-reversion explores the investment strategies. This study examines the pricing of forward start options based on the uncertain mean-reverting stock model by applying Liu’s uncertain finance. Call and put options pricing formulas are derived. The study depicts that the pricing patterns in uncertain environments are consistent with the common characteristics of financial markets.
A tutorial review of machine learning-based model predictive control methods
Authors: Wu Zhe , Christofides Panagiotis D. , Wu Wanlu , Wang Yujia , Abdullah Fahim , Alnajdi Aisha , Kadakia Yash 
Published: December 2024

Abstract
This tutorial review provides a comprehensive overview of machine learning (ML)-based model predictive control (MPC) methods, covering both theoretical and practical aspects. It provides a theoretical analysis of closed-loop stability based on the generalization error of ML models and addresses practical challenges such as data scarcity, data quality, the curse of dimensionality, model uncertainty, computational efficiency, and safety from both modeling and control perspectives. The application of these methods is demonstrated using a nonlinear chemical process example, with open-source code available on GitHub. The paper concludes with a discussion on future research directions in ML-based MPC.
Role of interferon regulatory factors in predicting the prognosis of Crimean-Congo hemorrhagic fever
Authors: Öksüz Caner , Doğan Halef Okan , Zararsız Gökmen , Elaldı Nazif , Büyüktuna Seyit Ali 
Published: December 2024

Abstract

Objectives
Crimean-Congo hemorrhagic fever (CCHF) is a severe viral illness with a high fatality rate. The interferon response plays a crucial role in the antiviral defense against the CCHF virus (CCHFV). Interferon regulatory factors (IRFs) are essential for initiating and amplifying the interferon response. In this study, we aimed to evaluate the IRF response in CCHF patients for the first time.

Methods
This study investigated the expression levels of various IRFs (IRF-1, 2, 3, 4, and 7) in CCHF patients and evaluated their potential association with disease prognosis. The research encompassed a cohort of 60 CCHF patients and 30 healthy volunteers. CCHF was diagnosed with CCHFV positivity using PCR method and/or IgM detection using ELISA method. The quantitative sandwich ELISA technique was employed to determine the levels of serum IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, interferon (IFN)-alpha, and IFN-beta.

Results
There were statistically significant differences in the levels of serum IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, IFN-alpha, and IFN-beta between the patient and healthy control groups. Patients showed elevated levels in all these factors except for IRF-1. However, no statistically significant differences were found in IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, IFN-alpha, and IFN-beta levels between patients who survived and those who died.

Conclusions
IFN-alpha and beta likely contribute to the immune response in CCHF. IRF-2, 3, 4, and 7 play crucial roles in IFN-alpha and beta expression, pivotal for the antiviral response in CCHF. Targeted interventions to modulate IRF-1 could alleviate disease severity and overall impact.
Auswirkungen von Laststeuerungsprogrammen auf Lieferketten
Authors: Füchtenhans Marc , Glock Christoph H. 
Published: December 2024

Abstract
Anreizbasierte Laststeuerungsprogramme ermöglichen es Netzbetreibern, die Stromnachfrage zu beeinflussen, die Netzstabilität zu erhöhen und erneuerbarer Energien besser zu integrieren. Während die Wirksamkeit dieser Anreize auf Stromnetze und die industrielle Planung in Studien untersucht wurde, fehlt eine Untersuchung ihrer Auswirkungen auf Lieferketten. In diesem Beitrag wird eine dreistufige Lieferkette analysiert, in der ein Hersteller Bestellungen von Großhändlern erhält und seine Produktion unter Berücksichtigung eines Laststeuerungsprogramms plant. Mit Hilfe einer numerischen Simulation wird der Einfluss solcher Programme auf Lagerbestände, die Lieferfähigkeit der Großhändler und die Auswirkungen auf Lieferketten untersucht.
Simulation und Bewertung von Fahrzeug-Produktionsstrategien
Authors: Hilmer Maximilian , Riedel Ralph , von Unwerth Thomas 
Published: December 2024

Abstract
Die Automobilindustrie steht aktuell vor großen Unsicherheiten und Herausforderungen. In diesem Spannungsfeld ist es für die Automobilhersteller entscheidend das Fahrzeugproduktionsnetzwerk strategisch richtig auszulegen, um den Mix an Antriebsarten kostenoptimiert produzieren zu können. Der vorliegende Beitrag liefert dazu, auf Basis eines konzipierten Simulationsmodells und der Anwendung an einem Fallbeispiel, Analysen und Bewertungen von verschiedenen Produktionsstrategien.
Frühzeitige Bewertung von Auswirkungen bei der Einführung neuer Produktvarianten
Authors: Demir Mehmet , Hingst Lennart , Schmidt Matthias , Nyhuis Peter 
Published: December 2024

Abstract
Um wettbewerbsfähig zu bleiben, müssen Unternehmen ein vielfältiges Produktportfolio anbieten, das den individuellen Wünschen der Kunden entspricht. Dies führt zu einer zunehmenden Variantenvielfalt und steigenden Kosten in Fabriksystemen. Die frühzeitige Erkennung der Unwirtschaftlichkeit von Produktvarianten vor Produktionsbeginn ist dabei von entscheidender Bedeutung. In diesem Beitrag wird die Relevanz und Kritikalität von Entscheidungen über die Einführung zusätzlicher Produktvarianten für Fabriksysteme aufgezeigt. Darauf aufbauend werden Anforderungen an ein Bewertungs- und Entscheidungsmodell formuliert, das die Vorhersage von Folgekosten im Fabriksystem ermöglicht.
Standortstrategieentwicklung und Roadmapping in globalen Produktionsnetzwerken
Authors: Martin Michael , Höß Carlos Wilhelm , Buchholz Johannes , Steier Gwen , Benfer Martin , Lanza Gisela 
Published: December 2024

Abstract
Globale Produktionsnetzwerke sind der zunehmenden Dynamik, Komplexität und Unsicherheit ihrer globalen Umwelt ausgesetzt. Dies liegt an zumeist historisch gewachsenen Netzwerken, die keine klare Strategie und die damit verbundene definierte Konfiguration besitzen. Die in diesem Beitrag vorgestellte Methodik zeigt, wie basierend auf einer Netzwerkanalyse bestehende Herausforderungen identifiziert und eine neue Strategie entwickelt werden kann. Eine detaillierte Roadmap kann dabei die wesentlichen Schritte zur Erreichung der Strategie und einer darauf abgestimmten Netzwerkkonfiguration zusammenfassen.
Kreislauffähige Produktionsnetzwerke
Authors: Peukert Sina , Martin Michael , Prank Steffen , Covre Luca 
Published: December 2024

Abstract
Um produzierende Unternehmen in der Transformation zu zirkulären Ökosystemen unterstützen zu können, wird die schrittweise Entwicklung einer ganzheitlichen Entscheidungsunterstützungsmethodik beschrieben. Basierend auf ausgewählten Kennzahlen erfolgt eine Bestimmung des Zirkularitätsreifegrads mit anschließender Ableitung potentiell zirkularitätsfördernder Maßnahmen, die daraufhin simulativ in Netzwerkkonfigurationen erprobt und bewertet werden.
IIoT-basierte Geschäftsmodelle für Komponentenhersteller
Authors: Dickopf Thomas , Forte Sven , Meinberg Yannik , Weber Markus 
Published: December 2024

Abstract
Dieser Beitrag zeigt am Beispiel eines deutschen Komponentenherstellersfür Motorspindeln, wie das Service-Geschäft durch neue technologische Ansätze revolutioniert werden kann. Durch die Anwendung der AAS in Edge-Cloud-Umgebungen wird über Datenmanagementsystemen Datendurchgängigkeit entlang des Lebenszyklus bis hin zu einem Serviceangebot in einem Gaia-X-basierten Ökosystem gewährleistet und gleichzeitig die industrielle Tauglichkeit dieser Ansätze und der Mehrwert für Anwender verdeutlicht.
Intelligente Wertschöpfungsnetzwerke für individuelle Fahrzeugentwicklung
Authors: Bönsch Jakob , Jelschow Vladimir , Haking Moritz , Bobbou Sleiman , Deisser Oliver 
Published: December 2024

Abstract
Die Entwicklung und Produktion von individuellen Fahrzeugen in Kleinserien bietet ein bislang nicht gehobenes und von Konzernen und großen OEMs vernachlässigtes Marktpotenzial. Der Aufbau eines digitalen Ecosystems für individuelle Fahrzeugentwicklung gibt kleinen und mittleren Unternehmen die Möglichkeit, dieses Marktsegment selbst zu besetzen. Der gemeinsame Datenraum und standardisierte Kernleistungen ermöglichen eine radikale Zusammenarbeit entlang des gesamten Ende-zu-Ende-Prozesses.
Mit vorausschauenden Produktionsstrategien Wachstum in sich wandelnden Märkten erreichen
Authors: Mezger Michael , Jurgeleit Thomas , Kopp Alexander 
Published: December 2024

Abstract
Produzierende Unternehmen sind zahlreichen Abhängigkeiten unterworfen und unterliegen in der modernen, volatilen Geschäftswelt ständigen Veränderungen. Das birgt einerseits Risiken, weil das bereits gesicherte Auftragsvolumen gewisse Schwankungen erfahren kann. Zugleich eröffnet es aber auch Chancen, weil Unternehmen Kapazitäten für neue Aufträge gewinnen und sich weiterentwickeln können. Um zukunftsfähig zu bleiben, reicht es nicht aus, sich allein auf Vergangenheitswerte, grobe Schätzungen und Momentaufnahmen zu verlassen, um für neue Produkte und Kundenprojekte oder mögliche Auftragsmengensteigerungen die erforderlichen Kapazitäten bereit zu stellen. Notwendig ist ein klares Verständnis für die Grundauslastung der Produktion und die Befähigung, auf zukünftige Ereignisse wie Wachstum, aber auch Krisen zu reagieren. Möglich wird das mit einem strukturierten Baseline Management.
Thyroid response to blocking sympathetic activity in chronic cold-exposed hunters in East Greenland: a case–control study
Authors: Jensen Mette Motzfeldt , Almasi Charlotte Elberling , Florian-Sørensen Hans Christian , Andersen Stine Linding , Andersen Stig 
Published: December 2024

Graphical AbstractAbstractBackgroundThyroid hormones and sympathetic stimulation are needed for activating brown adipose tissue (BAT) during cold exposure. Studies of human cold exposure have demonstrated both increased production and raised clearance of triiodothyronine (T3). Greenlandic hunters provide a unique model for evaluating metabolic effects of cold exposure.AimWe aimed to explore the dynamics of thyroid hormones when blocking sympathetic activity in Greenlandic hunters during winter to inspire knowledge on mechanisms of BAT activation.MethodsWe conducted a 7-day field study of Greenlandic hunters (n = 7) in East Greenland in February. The sympathetic system was blocked using a non-selective beta blocker for seven consecutive days. A group of non-hunter Greenlanders (n = 8) from the same settlement was included for parallel sampling. All participants were healthy men. Blood samples were drawn daily for measurement of TSH, thyroid hormone levels and thyroglobulin.ResultsHunters had higher serum thyroglobulin, TSH and fT3/fT4 ratio compared to controls. Blocking the sympathetic activity was followed by changes in serum thyroglobulin and fT3 with an initial decrease and subsequent restoration of levels, while TSH and fT4 showed a gradual increase over the course of the study. The fT3/fT4 ratio showed a continuous and marked decrease.ConclusionWe speculate that when blocking the sympathetic system, TSH increases to uphold the production of T3 needed for maintaining BAT activity. In addition, alterations of fT3/fT4 ratio support a hypothesis of adrenergic stimulation promoting T3 over T4 secretion from the thyroid via adrenergic nerve terminals in the thyroid.
Dramatic Space: Translating Euripides’ Medea into Lithuanian, Latvian, and Estonian
Authors: Dikmonienė Jovita , Bodniece Līva , Lotman Maria-Kristiina 
Published: December 2024

This article analyzes the translations of Euripides’ Medea into Lithuanian, Estonian and Latvian languages. It investigates how translators convey or adapt the original space of ancient theatre and drama in the meta-discourse and discourse of tragedy. The article has three main parts devoted to Benediktas Kazlauskas’ Lithuanian translation, Augusts Ģiezens’ Latvian translation, and Tiit Palu’s Estonian adaptation. Each part is divided into subsections, where the mimetic and diegetic space of ancient drama, stage directions, and objects of space: house, bed, and door are analyzed. The meta-discourse of Kazlauskas and Ģiezens is compared to the English translation by David Kovacs. The study examines what new symbolic meanings Euripides assigns to spatial objects and how he reinterprets the meanings of home as a place of security and family, giving it new connotations. The article concludes that the translations of Euripides’ Medea from the three Baltic countries represent the dramatic space differently because the translators adhere to different ideologies.
The philological translations of Kazlauskas and Ģiezens are similar due to the rendering of the ancient meter and are focused on the reader, while Tiit Palu’s adaptation is made for the theatre. Kazlauskas calls Medea’s house a “palace”, giving the space epicness, solemnity and formality. It can also be seen that his euphemistic language reflects the censorship of the Soviet era – not to translate words denoting the sexual sphere. Ģiezens’ translation into Latvian emphasizes the personal and intimate aspects of the drama. Tiit Palu’s Estonian adaptation focuses on the psychological depth of the drama, partially preserving the spatial and architectural integrity of the original while contextualizing ancient myth in the contemporary situation to make it more accessible for a modern audience. Each translator adapts the dramatic space to suit cultural contexts, balancing fidelity to Euripides’ original with accessibility to modern readers and audiences.
Factors Associated With Early Computed Tomography Imaging in Children Hospitalized With Severe Orbital Infections
Authors: Yu Winnie W. , Borkhoff Cornelia M. , Mahant Sanjay , Drouin Olivier , Pound Catherine , Quet Julie , Wahi Gita , Bayliss Ann , Vomiero Gemma , Foulds Jessica L. , Kanani Ronik , Sakran Mahmoud , Sehgal Anupam , Cichon Jessica , Pullenayegum Eleanor , Widjaja Elysa , Reginald Arun , Wolter Nikolaus E. , Parkin Patricia C. , Gill Peter J. 
Published: December 2024

OBJECTIVE
We identified factors associated with computed tomographic (CT) imaging within 24 hours of emergency department (ED) presentation in hospitalized children with severe orbital infections.

PATIENTS AND METHODS
A multicenter retrospective cohort study was conducted that included children aged 2 months to 18 years between 2009 and 2018 who were admitted to the hospital with severe orbital infections, including periorbital and orbital cellulitis. Multivariable modified Poisson regression was used to identify possible factors associated with receiving a CT scan within 24 hours of ED presentation.

RESULTS
Of 1144 children, 494 (43.2%) received a CT scan within 24 hours of ED presentation. Factors associated with receiving a CT scan within 24 hours included sex (male; adjusted relative risk [aRR], 1.18; 95% CI, 1.04–1.33), hospitalized at a children’s hospital (aRR, 1.80; 95% CI, 1.32–2.45), consulted by both ophthalmology and otolaryngology (aRR, 3.12; 95% CI, 2.35–4.13) or either ophthalmology (aRR, 2.19; 95% CI, 1.66–2.90) or otolaryngology (aRR, 2.66; 95% CI, 1.84–3.86), and had proptosis (aRR, 1.39; 95% CI, 1.24–1.57) or eye swollen shut (aRR, 1.27; 95% CI, 1.13–1.43) as clinical signs upon ED presentation. Children aged younger than 5 years were less likely to receive early CT imaging (aRR, 0.63; 95% CI, 0.53–0.74). There were no associations between time of ED triage, temperature greater than 38 °C, or inflammatory markers with early CT imaging.

CONCLUSION
Although several patient and hospital factors associated with early CT imaging decisions in children with severe orbital infections are associated with more severe infections, newly identified risk factors, such as inflammatory markers, were not. These findings will help better the understanding of clinical management and indications for CT imaging.
How many syllables do you hear? Korean perception of English coda plosives
Authors: Kim Jungyeon 
Published: December 2024

AbstractThis study investigates the direct perception of foreign structures in loanword phonology, concentrating on whether Korean listeners unnecessarily perceive an illusory vowel after a word-final plosive of English since a word-final voiceless plosive is permissible in their native language. In a syllable counting experiment, Korean participants listened to English nonce forms ending in a plosive and they indicated the number of syllables in each word. This study examined six different linguistic factors that may contribute to the perception of loanword borrowers including release, voicing and place of coda plosive, vowel tenseness, final stress and word size. The current results show that Korean listeners do perceive an extra syllable when the English pseudoword ends in a released plosive or in a syllable containing a tense vowel. This finding supports the hypothesis of adaptation in perception that unmotivated vowel insertion results from the misperception of English words rather than from a production grammar maintaining perceptual similarity between the English form and Korean pronunciation.