bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrous Dysplasia: A Complex Maxillary Reconstruction
Authors: Mici Elidon , Belli Evaristo 
Published: June 2018

Abstract
Fibrous dysplasia is a benign tumor of the skeleton. Mostly 2 forms are described: a monostotic and a poliostotic form. The maxilla and the mandible are the most interested of the facial district. The authors report a patient of a huge maxillary fibrous dysplasia. A 63-year-old patient was treated for a 20-year progressive left maxillary neoformation. A total maxillectomy was performed. The defect was reconstructed with a custom-made midface implant associated with a temporal and a pericranial flap.
Auto-Fluorescence and Histopathologic Evaluation of Medication-Related Osteonecrosis of the Jaws: Perspectives for Treatment
Authors: Giovannacci Ilaria , Vescovi Paolo , Magnoni Cristina , Corradi Domenico , Corcione Luigi , Lucchina Alberta Greco , Mortellaro Carmen , Nammour Samir , Meleti Marco 
Published: June 2018

Abstract
Auto-fluorescence (AF) of healthy bone tissue has recently been described. Loss of AF (LAF) has, on the contrary, been reported in necrotic bone. Further, the use of LAF as a possible guidance to distinguish viable from necrotic bone during surgical treatment of osteonecrosis has been proposed. The aim of this study is to detail 8 patients of medication-related osteonecrosis of the jaws treated through an AF-guided surgical resection. The authors also provide the histopathologic description of hypo-fluorescent and hyper-fluorescent bone in each patient. After removal of necrotic bone block, Er:YAG laser was used for vaporizing further necrotic bone, up to the detection of strongly hyper-fluorescent bone. Samples of hyper-fluorescent bone were collected around areas of necrosis. Histopathologic evaluation revealed viable bone tissue in all hyper-fluorescent specimens. On the basis of these data, AF-guided surgical resection could be effective in highlighting surgical margins of necrotic bone tissue and it might have some utility in a range of applications of bone surgery.
Advanced Neuroimaging Techniques for Difficult Diagnoses: Giant Hemorrhagic Venous Infarct Or Not?
Authors: Polat Gökhan , Ogul Hayri 
Published: June 2018

Abstract
An 51-year-old female presented with a headache, nausea, vomiting, and weakness. The lesion resembling a hemorrhagic mass was observed in the brain tomography and magnetic resonance imaging of the patient. However, thrombosis was suspected in the cerebral venules adjacent to the lesion. Magnetic resonance spectroscopy and magnetic resonance perfusion data excluded neoplastic lesions. Thus, the patient was treated for venous infarction. Hemorrhagic venous infarcts may mimic hemorrhagic masses. For this reason, the distinction of the lesions is important for the treatment procedure. Advanced neuroimaging in lesions resembling hemorrhagic masses must be performed for accurate diagnosis.
Exposure Therapy and Simultaneous Repetitive Transcranial Magnetic Stimulation
Authors: Fryml Leah D. , Pelic Christopher G. , Acierno Ron , Tuerk Peter , Yoder Matthew , Borckardt Jeffrey J. , Juneja Natasha , Schmidt Matthew , Beaver Kathryn L. , George Mark S. 
Published: June 2018

Objectives
This is a small preliminary but novel study assessing the feasibility of repetitive transcranial magnetic stimulation (rTMS) delivery to veterans with posttraumatic stress disorder (PTSD) while they simultaneously receive prolonged exposure (PE) therapy.

Methods
A prospective, randomized, double-blinded, active sham-controlled design combined weekly sessions of rTMS and standard PE at the Veterans Administration Hospital. Eight adult patients received a full course of protocol-driven PE therapy and were randomly assigned to receive either rTMS or sham rTMS. Repetitive transcranial magnetic stimulation was delivered to the right or left prefrontal cortex with a figure-eight solid core coil at 120% motor threshold, 10 Hz, 5-second train duration, and 10-second intertrain interval for 30 minutes (6000 pulses) weekly for 5 weeks (30,000 stimuli).

Results
Of the 12 veterans consented, 8 completed the study treatment protocol. The dropout rate was 34%, roughly equivalent to the pooled average dropout rates observed in traditional PE therapy with Operation Enduring Freedom/Operation Iraqi Freedom veterans with PTSD, suggesting that veterans had no difficulty tolerating the addition of rTMS to PE therapy and that this is a feasible study design for larger trials in the future. Clinician-Administered PTSD Symptom scores reflected a general nonsignificant trend toward improvement, and subjects with comorbid major depression appeared to experience significant antidepressant benefit with treatment despite the fact that the doses used in this protocol were much smaller than those used to treat patients with major depressive disorder.

Conclusions
This pilot study demonstrates the safety and feasibility of rTMS delivery to PTSD patients while they simultaneously receive PE. This unique approach to the treatment of PTSD highlights the need for further studies with larger sample sizes to assess treatment outcomes.
Extensive Expansion of the Speedy gene Family in Homininae and Functional Differentiation in Humans
Authors: Wang Liang , Wang Hui , Wang Hongmei , Zhao Yuhui , Liu Xiaojun , Wong Gary , Ye Qinong , Xia Xiaoqin , Gao George F. , Gao Shan 
Published: June 2018

AbstractBackgroundThe cell cycle plays important roles in physiology and disease. The Speedy/RINGO family of atypical cyclins regulates the cell cycle. However, the origin, evolution and function of the Speedy family are not completely understood. Understanding the origins and evolution of Speedy family would shed lights on the evolution of complexity of cell cycles in eukaryotes.ResultsHere, we performed a comprehensive identification of Speedy genes in 258 eukaryotic species and found that the Speedy subfamily E was extensively expanded in Homininae, characterized by emergence of a low-Spy1-identify domain. Furthermore, the Speedy gene family show functional differentiation in humans and have a distinct expression pattern, different regulation network and co-expressed gene networks associated with cell cycle and various signaling pathways. Expression levels of the Speedy gene family are prognostic biomarkers among different cancer types.ConclusionsOverall, we present a comprehensive view of the Speedy genes and highlight their potential function.
Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations
Authors: Sakornsakolpat Phuwanat , Prokopenko Dmitry , Lamontagne Maxime , Reeve Nicola F. , Guyatt Anna L. , Jackson Victoria E. , Shrine Nick , Qiao Dandi , Bartz Traci M. , Kim Deog Kyeom , Lee Mi Kyeong , Latourelle Jeanne C. , Li Xingnan , Morrow Jarrett D. , Obeidat Ma’en , Wyss Annah B. , Zhou Xiaobo , Bakke Per , Barr R Graham , Beaty Terri H. , Belinsky Steven A. , Brusselle Guy G. , Crapo James D. , Jong Kim de , DeMeo Dawn L. , Fingerlin Tasha E. , Gharib Sina A. , Gulsvik Amund , Hall Ian P. , Hokanson John E. , Kim Woo Jin , Lomas David A. , London Stephanie J. , Meyers Deborah A. , O’Connor George T. , Rennard Stephen I. , Schwartz David A. , Sliwinski Pawel , Sparrow David , Strachan David P. , Tal-Singer Ruth , Tesfaigzi Yohannes , Vestbo Jørgen , Vonk Judith M. , Yim Jae-Joon , Bossé Yohan , Manichaikul Ani , Lahousse Lies , Silverman Edwin K. , Boezen H. Marike , Wain Louise V. , Tobin Martin D. , Hobbs Brian D. , Cho Michael H. ,   International COPD Genetics Consortium
Published: June 2018

SummaryChronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. To broaden COPD genetic risk loci discovery and identify cell type and phenotype associations we performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci with P value < 5×10−8; 47 were previously described in association with either COPD or population-based lung function. Of the remaining 35 novel loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified enrichment for loci in lung tissue, smooth muscle and alveolar type II cells. We found 9 shared genomic regions between COPD and asthma and 5 between COPD and pulmonary fibrosis. COPD genetic risk loci clustered into groups of quantitative imaging features and comorbidity associations. Our analyses provide further support to the genetic susceptibility and heterogeneity of COPD.
A novel bacterial class V dye-decolourizing peroxidase from the extremophile Deinococcus radiodurans: cloning, expression optimization, purification, crystallization, initial characterization and X-ray diffraction analysis
Authors: Frade Kelly Stefany Tuna , Fernandes Andreia Cecília Pimenta , Silveira Celia Marisa , Frazão Carlos , Moe Elin 
Published: June 2018

Deinococcus radiodurans is a bacterium with extreme resistance to desiccation and radiation. The resistance mechanism is unknown, but an efficient reactive oxygen species (ROS) scavenging system and DNA-repair and DNA-protection mechanisms are believed to play important roles. Here, the cloning and small- and medium-scale expression tests of a novel dye-decolourizing peroxidase from D. radiodurans (DrDyP) using three different Escherichia coli strains and three different temperatures in order to identify the optimum conditions for the expression of recombinant DrDyP are presented. The best expression conditions were used for large-scale expression and yielded ∼10 mg recombinant DrDyP per litre of culture after purification. Initial characterization experiments demonstrated unusual features with regard to the haem spin state, which motivated the crystallization experiment. The obtained crystals were used for data collection and diffracted to 2.2 Å resolution. The crystals belonged to the trigonal space group P31 or P32, with unit-cell parameters a = b = 64.13, c = 111.32 Å, and are predicted to contain one DrDyP molecule per asymmetric unit. Structure determination by molecular replacement using previously determined structures of dye-decolourizing peroxidases with ∼30% sequence identity at ∼2 Å resolution as templates are ongoing.
Using design thinking to support value-based leadership for sustainable quality development
Authors: Snyder Kristen , Ingelsson Pernilla , Bäckström Ingela 
Published: June 2018

Purpose
The purpose of this paper is to present findings from a study of value-based leadership in which design thinking was used as a participatory, iterative process to examine and stimulate changes in organizational culture and develop value-based leadership in Swedish manufacturing. Of particular interest to the authors was to make visible and understand the constraints in leadership that kept leaders from understanding and working with organizational culture and values.

Design/methodology/approach
A three-year multi-site case study was conducted in collaboration with three manufacturing companies in Sweden. The study design was based on a collaborative, iterative model using the Stanford Design thinking framework in which data were collected through a series of workshops using a variety of sources including: leadership survey; interviews with three general directors; focus groups with middle- and top-level managers; observations and cultural analysis, survey; storytelling and appreciative inquiry (AI); and an employee questionnaire. Respondents in the study represented leadership teams in three Swedish manufacturing companies and their employees.

Findings
In general, there is a lack of dialogue among leaders about what is leadership, what is culture and what is meant by values in the organization. As well, there is a heavy emphasis on structure and process, yet, at the same time, there lacks a clear understanding about why the structures exist and how they can be used to spawn innovation. Moreover, participating leaders in manufacturing succumb to a crisis leadership model that results from the heavy emphasis on productivity and bottom-line effectiveness. Design thinking and the methods used to develop work culture, including AI, storytelling and coaching, provided leaders with new insights into the culture within the company. Leaders were able to identify both constraints and possibilities for changing the culture from disengagement to engagement. Through the process, they also began to identify values and recognized the importance of valuing employees to affect innovation and build a culture of engagement. The authors also witnessed increased dialogue among leaders that reflected an understanding of the importance to engage middle managers and employees in problem solving and innovation.

Originality/value
This study demonstrates that leaders can benefit from innovative approaches to identifying and building work culture to achieve value-based leadership.
Causal paths to acceptance of technological innovations by individual employees
Authors: Talukder Majharul 
Published: June 2018

Purpose
Despite much research on organizations’ adoption of innovation, little is currently known about individual employees have gone about it. The purpose of this paper is to empirically investigate the determinants that address individual employees’ decisions concerning innovation in the workplace.

Design/methodology/approach
Data were collected from 272 employees from a tertiary education institution in Australia using a structured instrument.

Findings
Results from the structural equation modeling analysis indicate that enjoyment and motivation impact significantly on attitudes to an innovation, which, in turn, affects how employees behave toward it.

Practical implications
Furthermore, organizational patronage, innovativeness and self-image have been found to influence the innovation adoption process. These findings have implications for the effective management and implementation of an innovation at the individual level.

Originality/value
Although innovation adoption has been studied extensively, drivers of adoption and research on individual innovation acceptance remain limited. Designing an effective approach for increasing end-user acceptance and subsequent use of innovation continues to be a fundamental challenge. The current literature indicates that we know relatively little about the ways in which individuals adopt and the factors that influence individual adoption of innovation. This study is designed to fill that gap. The identification of the factors is important to create a work environment that is conducive to individual adoption of innovation and thereby gain the expected benefits from the innovation.
Responding to 4G telecom pricing war: ignore, accommodate or retaliate
Authors: Pandey Neeraj , Kumar Anish 
Published: June 2018

Subject area
Marketing, Pricing, Strategic marketing.

Study level/applicability
The case is developed for an MBA-level program.

Case overview
In May 2017, the telecom industry in India witnessed an intense price war over 4G (fourth generation) data prices. Gopal Vittal, CEO of Bharti Airtel was exploring various options on how best to respond to the situation. He had to take a final call regarding Bharti Airtel’s marketing team’s counter move to tackle this price war by Jio – should Bharti Airtel ignore it, accommodate it or retaliate with even lower prices? Bharti Airtel strongly believed that Jio pricing structure had violated “fair pricing” norms, and its pricing was anti-competitive. It had filed a case with the Telecom Regulatory Authority of India (TRAI) and the Competition Commission of India (CCI) to restrain Jio from further giving “free” promotional offers and penalize it for it. Could the legal recourse by Bharti Airtel dampen Jio’s consistent subscriber growth rate?

Expected learning outcomes
The case provides the students with an insight into how the competition focused on pricing happens in the telecom industry. The pricing war affects the profit margin of all competing companies. It changes the customer reference point for evaluating the competing products and services. The students would also learn practical applications of positive-sum pricing, pricing war, fair pricing and legal aspects of pricing. This case provides the students with an opportunity to understand the pricing war and how to respond to it in a particular situation; understand positive-sum pricing and negative-sum pricing in telecom industry context; understand legal aspects of pricing; and how to leverage data for gaining newer customer insights.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing.
McDonald’s India – plotting a winning strategy
Authors: Pradhan Swapna 
Published: June 2018

Subject area
Business strategy.

Study level/applicability
The case has been written with the objective of enabling the students to understand the dynamics of a rapidly changing emerging market. It is structured for use at a Master-level course and an MBA audience in the subject of Business Strategy.

Case overview
The case details the growth story of American fast food chain McDonalds in West and South India markets. Westlife Development Limited (WDL) operates McDonald’s chain of quick service restaurants (QSR) in these markets; they entered the markets in the year 1996 and since then have adopted various market strategies such as investments in multiple format QSRs, aggressive rollouts of new QSRs, increase in product variants etc. for a sustained growth trajectory. However, the increased competition from both the national and international QSR brands and the new segment of competition from “techie” food aggregators challenges their prospects to maintain a number one position in these markets. As Amit Jatia – the Vice President of WDL − prepares his presentation for the scheduled Executive Leadership Team meeting, he seeks answers to two prime questions a) How could WDL once again regain the number one status in these markets? b) What best strategies the team needs to adopt to remain relevant to the Indian consumers?

Expected learning outcomes
The case study should enable the student: 1. To comprehend the complexities of the Indian QSR market and its competitive dynamics 2. To analyze the factors contributing to the growth of the India QSR sector. 3. To identify the market factors that led WDL to adapt their strategy to the market 4. To understand the significance of business strategy localization as adopted by WDL in the markets of West and South India. 5. To evaluate sources of competitive advantage for McDonald’s in the West and South India markets.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
The need for informed climate-health governance
Authors: Shea Brittany , Knowlton Kim , Shaman Jeffrey 
Published: June 2018

Purpose
The purpose of this paper is to discuss the existing opportunity to educate future health professionals on the health impacts of climate change in order to facilitate more informed planning and health governance.

Design/methodology/approach
The authors provide context for climate and health education and how it can lead to better-informed health governance, discuss how health can be used to motivate climate action, and provide examples of climate and health governance. In addition, they outline the climate and health educational components needed in health profession curricula and provide an example of an effort currently being implemented to support and coordinate climate and health education at health professions institutions.

Findings
Although action to address the health impacts of climate change is taking place, more climate-health policy and informed governance is needed. In addition, climate and health education must be included in the curricula of all health professions institutions to provide critical know-how on this topic.

Originality/value
The authors seek to advance the discussion around the need for climate and health education in schools and programs of public health, medicine, and nursing to better prepare students for their future roles as health practitioners.
Adoption and implementation potential of the lean concept in the petroleum industry: state-of-the-art
Authors: Rachman Andika , Ratnayake R.M. Chandima 
Published: June 2018

PurposeA systematic literature review is performed to reveal the state-of-the-art in the implementation of lean principles in the petroleum industry. This paper aims to generate a conceptual framework and reveal research gaps with respect to lean concept application in the petroleum industry.Design/methodology/approachAfter formulating research questions, the search strategy is generated, followed by data extraction, literature review and synthesis of the results. The search covers any studies in peer-reviewed scientific journals and conference proceedings in the period 1990-2017 that discuss the implementation of the lean concept in the petroleum industry.FindingsThe lean concept has been used to improve operational and technical aspects, contractor/supplier relationships, team organization and project management practice in the petroleum industry. Based on the literature review, a conceptual framework is generated comprising four main elements: leadership and commitment from management, employee involvement, cooperation and trust with contractors/suppliers and lean project management. These elements are the pillars that are founded on lean philosophy and principles to support technical/operational improvement in the organization. The types of literature identified indicate that the subject of the study is still immature.Research limitations/implicationsThis study focuses only on the upstream sector of the petroleum industry, which restricts the generalizability of the results to midstream and downstream businesses.Practical implicationsThis paper provides knowledge and information regarding the current state of lean implementation in the petroleum industry. The developed conceptual framework provides general guidance for practitioners regarding lean implementation in the petroleum industry, and is also expected to support research on theory building.Originality/valueFew studies have discussed the application of the lean concept in the petroleum industry. This paper contributes a platform for researchers and practitioners to comprehend how the lean concept has been applied in the petroleum industry, and provides a foundation for further studies on lean implementation in the petroleum industry.