bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology, evolution and transmission of human metapneumovirus in Guangzhou China, 2013–2017
Authors: Yi Lina , Zou Lirong , Peng Jingju , Yu Jianxiang , Song Yingchao , Liang Lijun , Guo Qianfang , Kang Min , Ke Changwen , Song Tie , Lu Jing , Wu Jie 
Published: October 2019

AbstractHuman metapneumovirus (hMPV), first identified in 2001, is a major viral respiratory pathogen that worldwide reported. Fundamental questions concerning the dynamics of viral evolution and transmission at both regional and global scales remain unanswered. In this study, we obtained 32 G gene and 51 F gene sequences of hMPV in Guangzhou, China in 2013–2017. Temporal and spatial phylogenetic analyses were undertaken by incorporating publicly available hMPV G gene (978) and F gene (767) sequences. The phylogenetic results show different global distribution patterns of hMPV before 1990, 1990–2005, and 2006–2017. A sharply increasing hMPV positive rate (11%) was detected in Guangzhou 2017, mainly caused by the B1 lineage of hMPV. A close phylogenetic relation was observed between hMPV strains from China and Japan, suggesting frequent hMPV transmissions between these regions. These results provide new insights into hMPV evolution, transmission, and spatial distribution and highlight Asia as a new epicenter for viral transmission and novel variant seeding after the year 2005. Conducting molecular surveillance of hMPV in Asian countries is critical for understanding the global circulation of hMPV and future vaccine design.
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
Authors: Mendes Cindy , Lopes-Coelho Filipa , Ramos Cristiano , Martins Filipa , Santos Inês , Rodrigues Armanda , Silva Fernanda , André Saudade , Serpa Jacinta 
Published: October 2019

AbstractThe biochemical demands associated with tumor proliferation prompt neoplastic cells to augment the import of nutrients to sustain their survival and fuel cell growth, with a consequent metabolic remodeling. Fatty acids (FA) are crucial in this process, since they have a dual role as energetic coins and building blocks. Recently, our team has shown that FATP1 has a pivotal role in FA transfer between breast cancer cells (BCCs) and non-cancerous cells in the microenvironment. We aimed to investigate the role of FATP1 in BCCs and also to explore if FATP1 inhibition is a promising therapeutic strategy. In patients’ data, we showed a higher expression of FATP1/SLC27A1 in TNBC, which correlated with a significant decreased overall survival (OS). In vitro, we verified that FA and estradiol stimulated FATP1/SLC27A1 expression in BCCs. Additionally, experiments with estradiol and PHTPP (ER-β antagonist) showed that estrogen receptor-β (ER-β) regulates FATP1/SLC27A1 expression, the uptake of FA and cell viability, in four BCC lines. Furthermore, the inhibition of FATP1 with arylpiperazine 5k (DS22420314) interfered with the uptake of FA and cell viability. Our study, unraveled FATP1 as a putative therapeutic target in breast cancer (BC).
Target capture strategy selection in a simulated marksmanship task
Authors: Steinberg Noah J. , Brown Alexander A. , Schettino Luis F. 
Published: October 2019

AbstractThis paper examines how individuals track targets that move in relatively unpredictable trajectories. Gaze and behavioural data were captured as twenty two participants learned a simulated competitive marksmanship task known colloquially as the Death Star over six training days. Participants spontaneously selected one of two consistent target-tracking strategies with approximately equal probability. Participants employed either chasing behaviour, in which gaze follows a target’s trajectory before a shot, or ambushing behaviour, wherein gaze anticipates the trajectory and the participant intercepts a moving target predictively. All participants improved in task performance measures (completion time and number of shots), but did so at the expense of accuracy in missed shot attempts. Surprisingly, neither behavioural strategy offered a significant advantage in task performance measures, indicating that either may be equally effective in tackling a hand-eye coordination task with complex target motion such as the Death Star.
Prediction of pathological fracture in patients with metastatic disease of the lower limb
Authors: Howard Emma L. , Cool Paul , Cribb Gillian L. 
Published: October 2019

AbstractThe aim of this study was to investigate if the risk of pathological fracture can be predicted with the proportion of body weight that can be put through the affected leg in patients with metastatic bone disease of the lower limb. A prospective observational study was conducted in patients with metastatic disease in the lower limb. Receiver Operator Characteristic curves were used to identify the optimum threshold level of single stance weight bearing to predict fracture and compared to the Mirels score. Patients who underwent surgery could weight bear significantly less than those who did not have surgical intervention. The optimum threshold to predict pathological fracture was 85% of total body weight. No patient below the threshold level of 85% single stance body weight sustained a pathological fracture. The use of single stance body weight can be a useful in conjunction with the Mirels score to predict pathological fracture. If less than 85% of total body weight can be put through the affected limb, the risk of fracture increases, and consideration of treatment is suggested.
Comet 66P/du Toit: not a near-Earth main belt comet
Authors: Yang Bin , Jehin Emmanuël , Pozuelos Francisco J. , Moulane Youssef , Shinnaka Yoshiharu , Opitom Cyrielle , Hsieh Henry H. , Hutsemékers Damien , Manfroid Jean 
Published: October 2019

Context. Main belt comets (MBCs) are a peculiar class of volatile-containing objects with comet-like morphology and asteroid-like orbits. However, MBCs are challenging targets to study remotely due to their small sizes and the relatively large distance they are from the Sun and the Earth. Recently, a number of weakly active short-period comets have been identified that might originate in the asteroid main belt. Among all of the known candidates, comet 66P/du Toit has been suggested to have one of the highest probabilities of coming from the main belt.
Aims. The main goal of this study is to investigate the physical properties of 66P via spectroscopic and imaging observations to constrain its formation conditions. In particular, the isotopic abundance ratio and the ortho-to-para ratio (OPR) of gaseous species can be derived via high-resolution spectroscopy, which is sensitive to the formation temperature of the nucleus.
Methods. We obtained medium and high-resolution spectra of 66P from 300–2500 nm with the X-shooter and the UVES instruments at the Very Large Telescope in July 2018. We also obtained a series of narrow-band images of 66P to monitor the gas and dust activity between May and July 2018 with TRAPPIST-South. In addition, we applied a dust model to characterize the dust coma of 66P and performed dynamical simulations to study the orbital evolution of 66P.
Results. We derive the OPR of ammonia (NH3) in 66P to be 1.08 ± 0.06, which corresponds to a nuclear spin temperature of ~34 K. We compute the production rates of OH, NH, CN, C3, and C2 radicals and measure the dust proxy, Afρ. The dust analysis reveals that the coma can be best-fit with an anisotropic model and the peak dust production rate is about 55 kg s−1 at the perihelion distance of 1.29 au. Dynamical simulations show that 66P is moderately asteroidal with the capture time, tcap ~ 104 yr.
Conclusions. Our observations demonstrate that the measured physical properties of 66P are consistent with typical short-period comets and differ significantly from other MBCs. Therefore, 66P is unlikely to have a main belt origin.
Knowledge and Attitudes Towards Concussion in Western Province Rugby Union Senior Club Rugby Players
Authors: Kraak Wilbur , Coetzee Lize , Kruger Anika , Stewart Reeco , Vuuren Hanno van 
Published: October 2019

AbstractConcussion is a frequently occurring injury in rugby which is not usually reported to coaches or medical staff. Recognition and treatment of concussion should be a priority; however, education surrounding concussion knowledge and attitudes of the players have been lacking. The aim of this study was to investigate the knowledge and attitudes toward concussion in Western Province Rugby Union (WPRU) Super League senior club rugby players. This study focused on gathering quantitative information from WPRU club rugby players, using the Rosenbaum Concussion Knowledge and Attitudes Survey-Student Version (RoCKAS-ST). The correlation between the Concussion Attitude Index (CAI) and Concussion Knowledge Index (CKI) was (r=0.14). The CKI average for the players was (16.72±2.96). The participants answered 67% (16.72±2.96) of the CKI questions and 62% (46.54±5.75) of the CAI questions correctly. The participants demonstrated sufficient knowledge of concussion, as well as safe attitudes toward concussion. A small number of players lacked knowledge of symptoms and attitudes toward concussion, which may have been influenced by the importance of games. Overall, the participants in this study demonstrated superior knowledge and safe attitudes compared to other studies. The current study found that the players had good knowledge and safe attitudes regarding the severity of concussion.
A simplified table using validated diagnostic criteria is effective to improve characterization of colorectal polyps: the CONECCT teaching program
Authors: Fabritius Martin , Gonzalez Jean-Michel , Becq Aymeric , Dray Xavier , Coron Emmanuel , Brenet-Defour Lucie , Branche Julien , Gerard Romain , Lepage Côme , Poincloux Laurent , Lienhart Isabelle , Bonniaud Paul , Bounnah Mohamed Tayeb , Rivory Jérôme , Lépilliez Vincent , Subtil Fabien , Saurin Jean-Christophe , Ponchon Thierry , Jacques Jérémie , Pioche Mathieu 
Published: October 2019

Abstract
Introduction and study aims Accurate real-time endoscopic characterization of colorectal polyps is key to choosing the most appropriate treatment. Mastering the currently available classifications is challenging. We used validated criteria for these classifications to create a single table, named CONECCT, and evaluated the impact of a teaching program based on this tool.
Methods A prospective multicenter study involving GI fellows and attending physicians was conducted. During the first session, each trainee completed a pretest consisting in histological prediction and choice of treatment of 20 colorectal polyps still frames. This was followed by a 30-minute course on the CONECCT table, before taking a post-test using the same still frames reshuffled. During a second session at 3 – 6 months, a last test (T3 M) was performed, including these same still frames and 20 new ones.
Results A total 419 participants followed the teaching program between April 2017 and April 2018. The mean proportion of correctly predicted/treated lesions improved significantly from pretest to post-test and to T3 M, from 51.0 % to 74.0 % and to 66.6 % respectively (P < 0.001). Between pretest and post-test, 343 (86.6 %) trainees improved, and 153 (75.4 %) at T3 M. Significant improvement occurred for each subtype of polyp for fellows and attending physicians. Between the two sessions, trainees continued to progress in the histology prediction and treatment choice of polyps CONECCT IIA. Over-treatment decreased significantly from 30.1 % to 15.5 % at post-test and to 18.5 % at T3 M (P < 0.001).
Conclusion The CONECCT teaching program is effective to improve the histology prediction and the treatment choice by gastroenterologists, for each subtype of colorectal polyp.
Hybrid placement technique for hepatic hilar obstruction using a new uncovered self-expandable metal stent
Authors: Ogura Takeshi , Yamada Masanori , Ueno Saori , Fukunishi Shinya , Higuchi Kazuhide 
Published: October 2019

Abstract
Background and study aim Recently, a novel technique combining stent-in-stent (SIS) and side-by-side (SBS) technique (hybrid technique) has been reported. This technique may have application for hepatic hilar obstruction (HBO) because it reduces the number of times the stent mesh has to be passed. However, to the best our knowledge, evaluation of its use in that setting has not been reported. Recently, a new uncovered self-expandable metal stent (UCSEMS) has become available in Japan. The diameter of this stent delivery shaft is only 5.4 Fr, and the discrepancy between the guidewire and top of stent delivery system is strongly reduced. We herein report technical tips for hybrid metal stent deployment for high-grade HBO using this novel UCSEMS. Hybrid metal stent deployment using he novel UCSEMS was attempted in seven patients. Technical success was obtained in all patients. Mean procedure time was 33.3 minutes (range, 27 to 43). Clinical success was obtained in six patients. Median stent patency was 109 days (range, 48 – 160 days).In conclusion, the hybrid metal stent placement technique appears to be useful using the new UCSEMS because of its fine-gauge stent delivery system.
Möglichkeiten und Grenzen der enzymatischen Lokaltherapie
von Handverbrennungen
Authors: Billner Moritz , Promny Dominik , Reichert Bert 
Published: October 2019

ZusammenfassungBei Verbrennungsverletzungen spielen die Hände aufgrund ihrer Exposition und der
durch tiefdermale Schädigungen der Haut entstehenden funktionellen sowie
ästhetischen Einschränkungen eine besondere Rolle. Durch die Einführung des
enzymatischen, Bromelain basierten Wunddebridements wurde eine alternative
Behandlungsmethode zur Frühexzision von Verbrennungen geschaffen. Dargestellt
und diskutiert wird der Verlauf von drei Fällen mit enzymatischer Behandlung bei
tiefdermalen Verbrennungen an den Händen.
Volumetría de fascículos cerebrales en población sana
Authors: Hernández José Fernando , Bello-Dávila Leonardo , Ramírez Sergio Francisco , Marin Jorge , Rudas Jorge , Ordóñez-Rubiano Edgar G. , Vanegas Jenny Vicuña 
Published: October 2019

Resumen
Objetivo Desde la aparición de la tractografía, al tratarse de una técnica no invasiva y que usa la ampliamente conocida resonancia magnética (RM), el estudio de la sustancia blanca se ha facilitado. A partir de eso, se han logrado grandes descubrimientos en cuanto a fascículos cerebrales involucrados en funciones cognitivas. Sin embargo, su evaluación sigue siendo subjetiva y depende de la experiencia y entrenamiento del evaluador, razón por la cual se ha limitado su aplicabilidad en la práctica clínica. En ese sentido, es conveniente parametrizar volúmenes cerebrales de sustancia blanca en población sana a través de una herramienta electrónica que se pueda reproducir y así poderlo aplicar en enfermos.
Materiales y métodos Se reportan 10 sujetos sanos desde el punto de vista neurológico. Para cada sujeto, se adquirieron imágenes ponderadas por difusión y los resultados se visualizaron mediante FiberNavigator (http://scilus.github.io/fibernavigator). Finalmente, esa misma herramienta fue utilizada para purificar los fascículos objeto de estudio y realizar el conteo de las fibras.
Resultados Se obtuvieron valores de volumetría del fascículo longitudinal superior (FLS), fascículo longitudinal inferior (FLI), fascículo frontoccipital inferior (FFI), fascículo uncinado (FU) y fascículo del cíngulo (FC), identificando que no existen diferencias estadísticamente significativas entre el número de fibras que componen los fascículos cerebrales.
Discusión Los resultados alcanzados de la anatomía y la direccionalidad de fibras de los fascículos cerebrales de este estudio coinciden con el resto de la evidencia publicada hasta el momento, sin encontrar diferencias en cuanto a su organización y recorrido.
Conclusión Aunque esos resultados no sirven como valores de referencia para ser aplicados en pacientes con patología neurológica, brindamos información inexistente hasta el momento, con ese equipo en específico y la reproducción entre los distintos usuarios y el software.
Effects of Polymerization Mode and Interaction with Hydroxyapatite on the Rate of pH Neutralization, Mechanical Properties, and Depth of Cure in Self-Adhesive Cements
Authors: Camargo Fabiana S. A. S. , González Alejandra H. M. , Alonso Roberta C. B. , Di Hipólito Vinicius , D'Alpino Paulo H. P. 
Published: October 2019

Abstract
Objective The aim of the study was to evaluate the physicochemical properties of self-adhesive resin cements associated with hydroxyapatite (HAp) according to the polymerization activation.
Materials and Methods Specimens of cements (PermaCem 2.0 [DMG]; MaxCem Elite [Kerr], and RelyX U200 [3M ESPE]) were distributed into three groups: activation mode; self-cured and dual-cured modes; and association or not with HAp powder mode. The pH neutralization was evaluated as a function of time. Flexural strength and elastic modulus were also tested (0.5 mm/min.). The depth of cure was also analyzed using the scraping test (ISO 4049). Infrared spectroscopy was also used to collect the spectra of specimens to evaluate the chemical bonds. Statistical comparisons were conducted at 5% of significance.
Results The aggressiveness of the self-adhesive resin cements evaluated varied among the materials with a tendency for neutralization. Self-cure groups exhibited lower pH throughout the entire evaluation when compared with that of the dual-cure ones, irrespective of the addition of HAp. MaxCem Elite when photoactivated was the only cement influenced by the addition of the HAp in terms of mechanical properties. The self-adhesive cements tested presented equivalent depth of cure based on the ISO 4049 requirements, regardless of the evaluated factors.
Conclusions Based on the parameters evaluated, the results demonstrated that most of the self-adhesive cements remained unaltered or improved when mixed with HAp, regardless of the activation mode.
Bonding Strength of Luting Cement to Zirconia-Based Ceramic Under Different Surface Treatments
Authors: Mendes Fabio , Zanini Mauricio M. , Favarão Jamille , Camilotti Veridiana , Sinhoreti Mario A. C. , Mendonça Marcio J. , Consani Simonides 
Published: October 2019

Abstract
Objectives The aim of this study was to evaluate the bonding strength of self-adhesive luting cement to zirconia under different surface treatments.
Materials and Methods Thirty-two zirconia samples were randomly divided into eight experimental groups based on the surface treatment employed (Control: no surface treatment; PMM: wear with diamond bur; JAT: blasting with glass beads; PMA: wear with a medium-roughness milling machine; Primer: primer application on the surface without treatment; PMM +Primer: PMM treatment plus primer application; JAT+Primer: JAT treatment plus primer application; and PMA+Primer: PMA treatment plus primer application). Cement cylinders were built on the ceramic surfaces, and the groups were subdivided according to the storage time employed (i.e., 24 hours or 60 days). After storage, the samples were subjected to microshear testing.
Statistical Analysis The Kruskal–Wallis test followed by the Dunn test was employed for comparison between the groups (p < 0.05).
Results The PMM group yielded the optimal results and the mean values increased after both storage times following the primer application. The Control, PMA, and JAT groups gave similar results after 24 hours, while the JAT group gave superior results following primer application over this storage time. After 60 days of storage, all groups gave improved results following chemical treatment with a primer.
Conclusion It was concluded that mechanical preparation using the diamond bur followed by primer application significantly improved the bond strength between the ceramic and the luting cement.
Xeroradiography: Stagnated after a Promising Beginning? A Historical Review
Authors: Udoye Christopher I , Jafarzadeh Hamid 
Published: October 2019

ABSTRACTVarious methods have been introduced for obtaining radiographs. Xeroradiography which is a method of imaging uses the xeroradiographic copying process to record images produced by diagnostic x-rays. It differs from halide film technique in that it involves neither wet chemical processing nor the use of dark room. Literature on this subject is scarce. After an initial promising beginning, this imaging method, once thought to hold the key to endodontic imaging, got stagnated. A revisit of this promising endodontic imaging system would therefore be appropriate. The purpose of this study was to review xeroradiographic technique as a roentgenographic imaging system. (Eur J Dent 2010;4:95-99)
A Comparison of Mobile- and Fixed-Bearing Unicompartmental Knee Arthroplasties in the Treatment of Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis of 1,861 Patients
Authors: Huang Fei , Wu Dan , Chang Jun , Zhang Chi , Qin Kunpeng , Liao Faxue , Yin Zongsheng 
Published: October 2019

AbstractMany studies have compared mobile-bearing (MB) and fixed-bearing (FB) unicompartmental knee arthroplasties (UKAs) in patients with unicompartmental knee osteoarthritis (OA). The present systematic review and meta-analysis examined the differences in the clinical and radiological outcomes of MB UKA and FB UKA. PubMed, EMBASE, and Cochrane databases, as well as Google Scholar were searched for relevant studies. Randomized controlled trials (RCTs) and cohort studies that compared MB UKA and FB UKA were included. The weighted mean difference in the knee scores and range of motion (ROM) as well as the summary odds ratio of postoperative mechanical axis alignment, radiolucency, revision rate, and complications were calculated in the MB UKA and FB UKA groups. Finally, 2 RCTs and 11 cohort studies that involved 1,861 patients (1,996 knees) were included. The FB UKA group showed better postoperative Knee Society score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and ROM than the MB UKA group. However, the MB UKA group had more knees with a neutral limb alignment and a lower incidence of polyethylene wear than the FB UKA group. No significant differences were observed between the groups with respect to radiolucency, revision rate, and complications, such as arthritis progression, aseptic loosening, and postoperative pain. This meta-analysis has demonstrated that both prostheses provided excellent clinical outcomes and survivorship in patients with unicompartmental knee OA. The MB UKA group achieved the expected postoperative neutral limb alignment as compared with the FB UKA group, while the FB UKA group showed higher knee scores and superior ROM than the MB UKA group. Limited evidence is currently available; therefore, the results of our meta-analysis should be interpreted with caution.