bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Reference Genome Sequence for the European Silver Fir (Abies albaMill.): A Community-Generated Genomic Resource
Authors: Mosca Elena , Cruz Fernando , Gómez-Garrido Jèssica , Bianco Luca , Rellstab Christian , Brodbeck Sabine , Csilléry Katalin , Fady Bruno , Fladung Matthias , Fussi Barbara , Gömöry Dušan , González-Martínez Santiago C , Grivet Delphine , Gut Marta , Hansen Ole Kim , Heer Katrin , Kaya Zeki , Krutovsky Konstantin V , Kersten Birgit , Liepelt Sascha , Opgenoorth Lars , Sperisen Christoph , Ullrich Kristian K , Vendramin Giovanni G , Westergren Marjana , Ziegenhagen Birgit , Alioto Tyler , Gugerli Felix , Heinze Berthold , Höhn Maria , Troggio Michela , Neale David B 
Published: June 2019

AbstractSilver fir (Abies alba Mill.) is a keystone conifer of European montane forest ecosystems that has experienced large fluctuations in population size during during the Quaternary and, more recently, due to land-use change. To forecast the species’ future distribution and survival, it is important to investigate the genetic basis of adaptation to environmental change, notably to extreme events. For this purpose, we here provide a first draft genome assembly and annotation of the silver fir genome, established through a community-based initiative. DNA obtained from haploid megagametophyte and diploid needle tissue was used to construct and sequence Illumina paired-end and mate-pair libraries, respectively, to high depth. The assembled A. alba genome sequence accounted for over 37 million scaffolds corresponding to 18.16 Gb, with a scaffold N50 of 14,051 bp. Despite the fragmented nature of the assembly, a total of 50,757 full-length genes were functionally annotated in the nuclear genome. The chloroplast genome was also assembled into a single scaffold (120,908 bp) that shows a high collinearity with both the A. koreana and A. sibirica complete chloroplast genomes. This first genome assembly of silver fir is an important genomic resource that is now publicly available in support of a new generation of research. By genome-enabling this important conifer, this resource will open the gate for new research and more precise genetic monitoring of European silver fir forests.
Transzanális műtéti útmutató
Authors: Almási Kálmán , Ábrahám Szabolcs , Baracs József , Bursics Attila , Jánó Zoltán , Sztipits Tamás , Szűts Áron , Tóth Dezső , Zaránd Attila , Bánky Balázs 
Published: June 2019

Absztrakt:
A rectum jó- és korai rosszindulatú elváltozásainak kivizsgálási, sebészeti
kezelési, valamint betegkövetési elveit foglaltuk össze. Célunk a transanalis
minimálisan invazív műtéti technika hazai szakmai gyakorlatának egységes
szemléletű összefogása (szinopszis), valamint egy közös, hazai transanalis
műtéti audit (minőségellenőrzési) rendszer alapjainak a megteremtése.
Numerical simulation of the regime and geometric characteristics influence on the pressure loss of a low-flow aerothermopressor
Authors: Kobalava H. , Konovalov D. 
Published: June 2019

In this paper, a study of gasdynamic processes that occur in a low-flow aerothermopressor has been done. The aerothermopressor is a two-phase jet apparatus for contact cooling, in which, due to the removal of heat from the air flow, the air pressure is increased (thermogasdynamic compression) and its cooling is taken place. Highly effective operation of the aerothermopressor is influenced by primarily the flow part design and the water injected method in the apparatus. Constructive factors that influence energy costs to overcome friction losses and local resistances on the convergent-divergent sections of the aerothermopressor are exerted a significant impact on the working processes in the apparatus. In this paper, a study of a number of typical low-flow aerothermopressor models has been conducted by using computer CFD modeling. Determination of the main parameters of the air flow (total pressure, dynamic pressure, velocity, temperature, etc.) has been carried out for a number of taper angles of a confuser a and a diffuser b, as well as for a number of values of the relative air velocity in the working chamber M = 0.4-0.8. Comparison of the obtained data with experimental data has been carried out. The deviation of the calculated values of local resistances coefficients in the confuser and in the diffuser from those obtained by computer CFD modeling does not exceed 7–10%. The recommended angles were determined: confuser convergent angle – 30° and diffuser divergent angle – 6°, corresponding to the minimum pressure loss is 1.0 – 9.5 %, and therefore also to the maximum pressure increase as a result of the thermogasdynamic compression that occurs during injection and evaporation of liquid in the working chamber. Thus, analytical dependences are obtained for determining the local resistance coefficients for the confuser (nozzle) and the diffuser, which can be recommended to use in the design methodology for low-flow aerothermopressors.
Existence of an Unbiased Consistent Entropy Estimator for the Special Bernoulli Measure
Authors: Timofeev Evgeniy A. 
Published: June 2019

Let \(\Omega = A^N\) - be a space of right-sided infinite sequences drawn from a finite alphabet \(A = \{0,1\}\), \(N = {1,2,\dots} \), \[\rho(\boldsymbol{x},\boldsymbol{y}) = \sum_{k=1}^{\infty}|x_{k} - y_{k}|2^{-k} \] - a metric on \(\Omega\), and \(\mu\) - a probability measure on \(\Omega\). Let \(\boldsymbol{\xi_0}, \boldsymbol{\xi_1}, \dots, \boldsymbol{\xi_n}\) - be independent identically distributed points on \(\Omega\). We study the estimator \(\eta_n^{(k)}(\gamma)\) - of the reciprocal of the entropy \(1/h\), that are defined as. \[\eta_n^{(k)}(\gamma) = k \left(r_{n}^{(k)}(\gamma) - r_{n}^{(k+1)}(\gamma)\right),\] where \[r_n^{(k)}(\gamma) =\frac{1}{n+1}\sum_{j=0}^{n} \gamma\left(\min_{i:i \neq j} {^{(k)}} \rho(\boldsymbol{\xi_{i}}, \boldsymbol{\xi_{j}})\right),\] \(\min ^{(k)}\{X_1,\dots,X_N\}= X_k\), если \(X_1\leq X_2\leq \dots\leq X_N\). Number \(k\) and a function \(\gamma(t)\) - are auxiliary parameters. The main result of this paper isTheorem.Let \(m\) - be the Bernoulli measure with probabilities \(p_0,p_1>0\), \(p_0+p_1=1\), \(p_0=p_1^2\), then \(\forall eps>0\) some continuous function \(\gamma(t)\) such that \[\left|E\eta_n^{(k)}(\gamma) - \frac1h\right| <eps,\quad DD\eta_n^{(k)}(\gamma)\to 0,n\to \infty. \]
MANAGING STUDENTS & EMPLOYEES THROUGH COLLEGE INFORMATION MANAGEMENT SYSTEM (CIMS) – A CASE STUDY: SHINAS COLLEGE OF TECHNOLOGY (SHCT), OMAN
Authors: Ali Al Briki Maryam Humaid , Rahman Khan M. Firdouse 
Published: June 2019

Purpose: The objectives of the study were to critically analyze the effectiveness of CIMS in completing the registration / academic advising process at Shinas College of Technology and to critically analyze the effective functions of the CIMS to fulfill the role played by the CIMS.
Design/methodology/approach: For this research study, Simple random sampling method in selecting the samples of the survey. 180 samples were collected which include the faculty, students and users of the College Information Management System (CIMS) from Shinas College of Technology (ICT). The collected data underwent analysis using the SPSS and the findings were interpreted.
Findings: The study reveals that CIMS is characterized by its multiple functions; is user-friendly and flexible. CIMS has met the expectations of most of the users, despite the presence of a few technical problems requiring improvement.Educational Technology Center (ETC) ensures smooth, secure, safe and fast access. CIMS is subject to continuous assessment through periodic follow up by the Educational College Center from any external attacks etc. which is a welcoming feature.
Research limitations/Implications: The study suggests that CIMS users should be given training on the updates and necessary training to the CIMS maintenance crew.
Social implications: The study suggests thatthere is only a small group of individuals who handles and manages the entire program - installation of CIMS and periodic follow-up etc. and technical expertise is needed at the college level.
Originality/Value: No study have ever examined the Information Management System of HEIs in Oman.
PENETAPAN KADAR PARASETAMOL, KAFEIN DAN PROPIFENAZON SECARA SIMULTAN DALAM SEDIAAN TABLET DENGAN METODE KCKT
Authors: Yulyarti Endhah , Rifai Yusnita , Yulianty Risfah 
Published: June 2019

Parasetamol, kafein dan propifenazon dikombinasikan bersama dalam sediaan obat untuk memberikan efek analgetik. Penggunaan kombinasi obat semakin meningkat untuk mencapai efek terapi yang lebih baik dan penurunan toksisitas sehingga sangat penting untuk mengawasi kandungan zat aktif dalam formulasi farmasetik. Desain penelitian adalah eksperimental menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT) dengan detektor UV pada 273 nm, kolom ODS, fase gerak metanol dan air (50:50), laju alir 0,6 mL/menit dan volume penyuntikan 20 µL. Pada penelitian ini dilakukan uji kesesuaian sistem, serta penentuan presisi dan akurasi metode analisis. Hasil penelitian diperoleh uji kesesuaian sistem memenuhi syarat dengan standar deviasi relatif (RSD) waktu retensi dan luas puncak ketiga analit < 2%, dengan waktu retensi parasetamol, kafein dan propifenazon masing-masing pada 5,41, 6,33 dan 24,11 menit. Rata-rata hasil penentuan presisi parasetamol, kafein dan propifenazon berturut-turut sebesar 94,461±1,687; 94,642±1,768; dan 99,177±1,871% yang memenuhi persyaratan USP (90-110%) dengan RSD presisi 1,79; 1,87 dan 1,89% yang memenuhi kriteria penerimaan (≤ 2%). Rerata hasil akurasi parasetamol, kafein dan propifenazon menggunakan kadar 80, 100 dan 120% yaitu 99,732±0,949; 101,260±1,331 dan 99,700±1,506% memenuhi persyaratan rekoveri yaitu 98-102% untuk parasetamol dan kafein serta 97-103% untuk propifenazon. Berdasarkan hasil presisi dan akurasi maka metode penetapan kadar parasetamol, kafein dan propifenazon secara simultan menggunakan KCKT memenuhi persyaratan.
Potential Impact of 2020 US Decennial Census Data Collection on Disaster Preparedness and Population Mental Health
Authors: Gaston Symielle A. , Galea Sandro , Cohen Gregory H. , Kwok Richard K. , Rung Ariane L. , Peters Edward S. , Jackson Chandra L. 
Published: June 2019

Increasing in frequency and impact in the United States and worldwide, disasters can lead to serious mental health consequences. Although US census data are essential for disaster preparedness and the identification of community-level risk factors for adverse postdisaster mental health outcomes, the US Census Bureau faces many challenges as we approach 2020 Decennial Census data collection. Despite the utility of the information provided by the Census and American Community Survey (ACS), the 2020 US Census and subsequent ACS data face threats to validity. As a result, public health funding could be misallocated, and disaster preparedness and response efforts misinformed; this can also contribute to the worsening of mental health inequities, particularly in the context of disaster. Undercutting the Census and the ACS, rich data sources that allow representation of all people in the United States, is a step backward in our effort to mitigate the population mental health consequences of disasters.
Prevalence of non-single canals in mandibular premolars and correlations with other anatomical variants: an in vivo cone beam computed tomography study
Authors: Jang Young-Eun , Kim Yemi , Kim Bom Sahn , Kim Sin-Young , Kim Hyung-Jong 
Published: June 2019

Abstract
Background

A knowledge regarding anatomical variants is important to achieve success in endodontic treatment. Root canal treatment of mandibular first premolars (PM1s) is challenging due to the existence of numerous variations in canal configurations, including a C-shaped variant. We aim to determine the prevalence and morphologic characteristics of non-single canals of mandibular first (PM1s) and second (PM2s) premolars in a Korean population using cone beam computed tomography (CBCT) and to evaluate correlations between non-single canals of PM1s and other anatomical variants, such as distolingual roots (DLRs) in mandibular first molars (M1s) and C-shaped canals in mandibular second molars (M2s).

Methods

A total of 971 PM1s and 997 PM2s from 500 patients were examined in vivo by CBCT. Root canal configurations and C-shaped canals were determined in accordance with the Vertucci classification and Fan classification, respectively. The correlation between non-single canals in PM1s and DLRs in M1s was evaluated using logistic regression analysis.

Results

PM2s typically had one root (99.89%) with one canal (98.4%). Among PM1s with non-single canals (21.2%), Vertucci type V (10.9%) and C-shaped (3.7%) canals were prevalent. Among C-shaped PM1 canals, the majority were Vertucci type V (77.8%); a C-shaped configuration (C2) was predominant mostly at the middle and/or apical third of the root. After adjusting for other variables (i.e., sex, age, and side), C-shaped canals in PM1s was significantly correlated with the presence of DLRs in M1s (odds ratio = 2.616; 95% confidence interval, 1.257–5.443; p = 0.010).

Conclusions

The presence of C-shaped PM1 canals was positively related to the presence of DLRs in M1s. Although C-shaped canals in PM1s are difficult to distinguish, this finding could aid clinicians in predicting C-shaped canal configurations in PM1s of patients who exhibit DLRs in M1s.
Examining Health Care Providers’ and Middle-level Managers’ Readiness for Change: A Qualitative Study
Authors: Austin Tujuanna , Chreim Samia , Grudniewicz Agnes 
Published: June 2019

Abstract
Background

Readiness is a critical precursor of successful change; it denotes whether those involved in the change are motivated and empowered to participate in the change. Research on readiness tends to focus on frontline health care providers or individuals in non-managerial positions and offers limited attention to individuals in middle management positions who are expected to lead frontline providers in change implementation. Yet middle-level managers are also recipients of changes that are planned and decreed by those in higher positions. This study sought to examine frontline provider and middle-level manager individual readiness for change in the context of primary care program integration.

Methods

Using a qualitative case study approach, we examined how individuals in frontline provider and middle manager positions experienced six readiness factors: discrepancy, appropriateness, valence, efficacy, fairness and trust in management. Primary data consisted of semi-structured interviews with frontline providers and middle managers involved in the change, and meeting observation notes. Data were analyzed using first-cycle descriptive coding followed by second-cycle coding.

Results

The findings show that lack of clear lines of authority and communication have a cascading influence across the levels in the organization, and can hinder readiness for change at the middle manager and frontline provider levels. The findings also show that the notion of valence should be expanded to consider individuals’ evaluation of benefits not only to themselves but also to patients and the health system; that efficacy applies to both content and process of change; that both fairness and trust in management need to be more centrally incorporated in models of readiness for change.

Conclusions

Our study makes a contribution by nuancing and extending conceptualizations of individual readiness factors, and by highlighting the importance of middle manager readiness for change. Implications of the study include the need to consider readiness factors prior to the implementation of change and the importance of fostering readiness throughout various levels of the organization.
Shifting Care from Hospital to Community, A Strategy to Integrate Care in Singapore: Process Evaluation of Implementation Fidelity
Authors: Nurjono Milawaty , Shrestha Pami , Ang Ian Yi Han , Shiraz Farah , Eh Ke Xin , Toh Sue-Anne Ee Shiow , Vrijhoef Hubertus Johannes Maria 
Published: June 2019

Abstract
Background: Accessibility to efficient and person-centered healthcare delivery drive healthcare transformation in many countries. In Singapore, specialist outpatient clinics (SOCs) are commonly congested due to increasing demands for chronic care. To improve this situation, the National University Health System (NUHS) Regional Health System (RHS) started an integrated care initiative,the Right-Site Care (RSC) program in 2014. Through collaborations between SOCs at the National University Hospital and primary and community care (PCC) clinics in the western region of the county, the program was designed to facilitate timely discharge and appropriate transition of patients, who no longer required specialist care, to the community. The aim of this study was to evaluate the implementation fidelity of the NUHS RHS RSC program using the modified Conceptual Framework for Implementation Fidelity (CFIF), at three distinct levels; providers, organizational, and system levels to explain outcomes of the program and to inform further development of (similar) programs.

Methods: A convergent parallel mixed methods study using the realist evaluation approach was used. Data were collected between 2016-2018 through non-participatory observations, reviews of medical records and program database, together with semi-structured interviews with healthcare providers. Triangulation of data streams was applied guided by the modified CFIF.

Results: Our findings showed four out of six program components were implemented with low level of fidelity, and 9,112 suitable patients were referred to the program while 3,032 (33.3%) declined to be enrolled. Moderating factors found to influence fidelity included: (i) complexity of program, (ii) evolving providers’ responsiveness, (iii) facilitation through synergistic partnership, training of PCC providers by specialists and supportive structures: care coordinators, guiding protocols, shared electronic medical record and shared pharmacy, (iv) lack of organization reinforcement, and (v) mismatch between program goals, healthcare financing and providers’ reimbursement.

Conclusion: Functional integration alone is insufficient for a successful right-site care program implementation. Improvement in relationships between providers, organizations, and patients are also warranted for further development of the program.
Socio-demographic and clinical characteristics of diabetes mellitus in rural Rwanda: Time to contextualize the interventions? A cross-sectional study
Authors: Munganyinka Charlotte Bavuma , Musafiri Sanctus , Rutayisire Pierre-Claver , Mwihaki Loise , McQuillan Ruth , Wild Sarah 
Published: June 2019

Abstract
Aim

Existing prevention and treatment strategies target traditional risk factors for diabetes, yet this approach might not always be appropriate in some populations. This study aims to assess the socio-demographic and clinical characteristics of diabetes in rural Rwanda.

Methods

A cross-sectional, clinic-based study was conducted in which individuals with diabetes mellitus were consecutively recruited from April 2015 to April 2016. Demographic and clinical data were collected from patient interviews, medical files and physical examinations. Chi-square tests and T-tests were used to detect disproportionate numbers and means between rural and urban residents.

Results

A total of 472 participants were recruited, including 295 women and 315 rural residents. Compared to urban residents, rural residents had lower levels of education, more low-income work and limited access to running water and electricity. Diabetes was diagnosed at a younger age in rural residents (mean age 32±18 vs 41±17 years; p < 0.001). Physical inactivity, family history of diabetes and obesity were significantly less prevalent in rural than in urban individuals (44% vs 66%, 14.9% vs 28.7% and 27.6% vs 54.1%, respectively; p < 0.001). The frequency of fruit and vegetable consumption was lower in rural than in urban participants. High waist circumference was more prevalent in urban than in rural women and men (75.3% vs 45.5% and 30% vs 6%, respectively; p< 0.001). History of childhood under-nutrition was more frequent in rural than in urban individuals (22.5% vs 6.4%; p< 0.001).

Conclusions

Characteristics of people with diabetes in rural Rwanda appear to differ from those of individuals with diabetes in urban settings, suggesting that prevention strategies should differ between settings.
Clinical Outcome of Endovascular Coil Embolization For Cerebral Aneurysms In Asian Population In Relation To Risk Factors: A 3-Year Retrospective Analysis
Authors: Ahmad Saima 
Published: June 2019

Abstract
Background: This study reviews the impact of comorbidities on the success of endovascular coiling of both ruptured and unruptured intracranial aneurysms. Independent risk factors reviewed were age, sex, smoking and hypertension.
Methods

A 3-year retrospective analysis, performed to assess the clinical outcomes of patients with cerebral aneurysms treated endovascularly in Asian population. A total of 297 patients treated at a single center were included. Clinical outcomes were evaluated by regular follow-ups. A modified Rankin Scale was used to measure the clinical outcomes in patients.

Results

Study showed smoking had an adverse effect on clinical outcome, with smokers 35% less likely to recover, while hypertension played a minimal role with only 15%. It was found that aneurysms are more prevalent in women but women have a better chance of recovery. Men in their 20s and 30s have the best recovery, with comorbidities playing a negligible role. Similarly, patients who were above 40 had a lower chance of recovery compared to younger patients due to comorbidities irrespective of gender.
Conclusions:

Asian sub-continent has different genetic marker that lead to poorer outcomes of aneurysms in women, while outcomes are similar in men and women in developed nations. Smoking does not play a major role in women’s recovery. Men with comorbidity of smoking and hypertension were seen to be at higher risk and age played a major role in recovery.
An audit of electron microscopy in the diagnosis of focal segmental glomerulosclerosis – are current pathological techniques missing important abnormalities in the glomerular basement membrane?
Authors: Davis Justin , Tjipto Alwie , Hegarty Katharine , Mallett Andrew 
Published: June 2019

Abstract
Background There is an increasing appreciation that variants of the collagen IV genes may be associated with the development of focal segmental glomerulosclerosis (FSGS). On electron microscopy such variants may produce characteristic changes within the glomerular basement membrane (GBM). These changes may be missed if glomerular lesions histologically diagnosed as FSGS on light microscopy are not subjected to electron microscopy. BFSMethods We conducted a retrospective cohort analysis of all patients presenting to two hospitals who received a primary histological diagnosis of FSGS to see if these samples underwent subsequent electron microscopy. Each such sample was also scrutinised for the presence of characteristic changes of an underlying collagen IV disorder  FSResults A total of 43 patients were identified. Of these only 30 underwent electron microscopy. In two samples there were histological changes detected that might have suggested the underlying presence of a collagen IV disorder. Around one in three biopsy samples that had a histological diagnosis of FSGS were not subjected to electron microscopy. BFSConclusion Renal biopsy samples that have a histological diagnosis of primary FSGS not subjected to subsequent electron microscopy may potentially miss ultrastructural changes in the GBM that could signify an underlying collagen IV disorder as the patient’s underlying disease process. This could potentially affect both them and their families’ investigative and management decisions given potential for implications for transplant, heritability and different disease pathogenesis. This represents a gap in care which should be reflected upon and rectified via iterative standard care and unit-level quality assurance initiatives.