bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world experience of galcanezumab in the prevention of migraine in Spain: a systematic literature review
Authors: Pozo-Rosich Patricia , García-Azorín David , Díaz-Cerezo Silvia , Fernández-Montoya Julia , de Paz Héctor David , Núñez Mercedes 
Published: November 2024

IntroductionIn the context of migraine preventive therapy, new therapeutic modalities such as monoclonal antibodies targeting the calcitonin gene-related peptide receptor (CGRP) or ligand offer potential advantages over traditional preventive treatments.MethodsThis systematic literature review gathered recent real-world evidence from Spain on the use of galcanezumab, a CGRP-targeting treatment, in migraine patients. The review included observational studies in English or Spanish, published from August 2020 to August 2023, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane guidelines.ResultsA total of 29 publications involving 2,592 Spanish adult patients were identified, reporting relevant information on clinical outcomes (treatment effectiveness and safety), treatment persistence and patterns (switching from other therapies and time to discontinuation and restart), and patient-reported outcomes (including satisfaction with treatment). The most frequently reported variables were related to the clinical effectiveness of galcanezumab, demonstrating a significant reduction in monthly migraine days and monthly headache days. Additionally, adverse impact of headache per HIT-6 (Headache Impact Test-6) and disability per MIDAS (Migraine Disability Assessment) also improve. Studies also showed that up to 12-month persistence to galcanezumab ranged from 76.8 to 59.8%. Serious adverse events were rare. None of the publications included health-related quality of life data, either generic or migraine-specific. One study highlighted that galcanezumab treatment would offer high patient satisfaction for people with migraine.ConclusionThe real-world evidence on the use of galcanezumab treatment among the Spanish population shows that its effectiveness, persistence, safety, and impact on health burden align with findings from clinical trials and observational studies conducted in other countries. Future studies should incorporate health-related quality of life data to gain a more holistic understanding of this treatment’s impact.
Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning
Authors: Kim Yuwoong , Gut Nadine K. , Shiflett Michael W. , Mena-Segovia Juan 
Published: November 2024

IntroductionThe pedunculopontine nucleus (PPN) plays a role in coordinating complex behaviors and adapting to changing environmental conditions. The specific role of cholinergic neurons in PPN function is not well understood, but their ascending connectivity with basal ganglia and thalamus suggests involvement in adaptive functions.MethodsWe used a chemogenetic approach in ChAT::Cre rats to explore the specific contribution of PPN cholinergic neurons to behavioral flexibility, focusing on the adaptation to shifting reward contingencies in a Reversal Learning Task. Rats were first trained in a non-probabilistic reversal learning task, followed by a probabilistic phase to challenge their adaptive strategies under varying reward conditions.ResultsMotor functions were evaluated to confirm that behavioral observations were not confounded by motor deficits. We found that inhibition of PPN cholinergic neurons did not affect performance in the non-probabilistic condition but significantly altered the rats’ ability to adapt to the probabilistic condition. Under chemogenetic inhibition, the rats showed a marked deficiency in utilizing previous trial outcomes for decision-making and an increased sensitivity to negative outcomes. Logistic regression and Q-learning models revealed that suppression of PPN cholinergic activity impaired the adaptation of decision-making strategies.DiscussionOur results highlight the role of PPN cholinergic neurons in dynamically updating action-outcome expectations and adapting to new contingencies. The observed impairments in decision-making under PPN cholinergic inhibition align with cognitive deficits associated with cholinergic dysfunction in neurodegenerative disorders. These findings suggest that cholinergic neurons in the PPN are essential for maximizing rewards through the flexible updating of behavioral strategies.
Hematopoietic stem cell transplantation to improve prognosis in aggressive monomorphic epitheliotropic intestinal T-cell lymphoma
Authors: Min Gi-June , Oh Ye Eun , Jeon Youngwoo , Kim Tong Yoon , Kim Byung-Su , Kwag Daehun , Park Sung-Soo , Park Silvia , Yoon Jae-Ho , Lee Sung-Eun , Cho Byung-Sik , Eom Ki-Seong , Kim Yoo-Jin , Lee Seok , Kim Hee-Je , Min Chang-Ki , Lee Jong Wook , Cho Seok-Goo 
Published: November 2024

IntroductionMonomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, aggressive subtype of primary gastrointestinal T-cell lymphoma. Owing to the absence of symptoms characteristic of MEITL, diagnosis can be challenging, and the low response rate to conventional chemotherapy leads to an abysmal prognosis. This study aimed to define the clinicopathologic characteristics of MEITL in Korea, evaluate the clinical outcomes of intensive chemotherapy with and without hematopoietic stem cell transplantation (HSCT), and explore prognostic factors.MethodsThis single-center retrospective study examined the clinical data of 35 patients diagnosed with MEITL at Seoul St. Mary’s Hospital from May 2012 to May 2023.ResultsWe included 22 men and 13 women (median age: 59 years; range: 37–79 years). Many patients exhibited acute abdominal pain (n=23, 65.7%) related to bowel perforation (n=21, 60.0%). Most patients (30/35, 85.7%) underwent surgical intervention to diagnose MEITL, whereas only five were diagnosed via endoscopic evaluation. Of the 32 patients receiving first-line therapy, 4 died before assessment, 10 achieved a complete response (CR), 6 had a relapse, and 18 exhibited progressive disease (PD). Seven of 10 patients received upfront HSCT, either autologous (auto-HSCT, n=4) or allogeneic (allo-HSCT, n=3). All four patients on auto-HSCT died after relapse. All three patients who received allo-HSCT maintained a CR by the final follow-up. Three of 6 patients who relapsed and 13 of 18 exhibiting PD received salvage therapy; one patient on salvage auto-HSCT with cytokine-induced killer cell infusion has survived progression free. Salvage allo-HSCT was performed on 6 of 16 patients; among them, 2 achieved a CR, 2 died after relapse, and 2 died owing to septic shock while maintaining a CR. The remaining patients, who received salvage therapy without HSCT, mostly died owing to PD. The median overall survival was 12.1 months, and the median follow-up was 33.2 months. The 1- and 5-year overall survival was 50.9% and 13.3%, respectively.DiscussionMEITL is an aggressive disease resistant to conventional therapy. Therefore, intensive chemotherapy followed by upfront allo-HSCT should be considered upon diagnosis. These findings underscore the need for novel therapeutic strategies and further investigation into optimizing treatment protocols for MEITL.
Dosimetric analysis of half-field-based VMAT with the deep inspiration breath-hold technique for left breast cancer patients following breast-conserving surgery
Authors: Wu Weiwei , Yin Hui , Liu Zhiwei , Liu Lipeng , Xiao Chengjian , Xiao Ying , Ding Jinquan , Zhang Qungui , Guo Hailiang 
Published: November 2024

ObjectiveCompared the dosimetric characteristics of half-field-based VMAT and half-field-based IMRT for left breast cancer patients combined with deep inspiration breath-hold (DIBH) and free breathing (FB) techniques.MethodsTwenty-one left breast cancer patients were included. Each patient underwent DIBH and FB CT scans, IMRT and VMAT plans in half-field beam mode for both breathing techniques, resulting in four plans: FB-IMRT (F-IMRT), FB-VMAT (F-VMAT), DIBH-IMRT (D-IMRT) and DIBH-VMAT (D-VMAT). The conformity index (CI), homogeneity index (HI), and the doses received at the heart, left anterior descending (LAD), left lung, right breast, and right lung, were compared among plans.The correlation between the difference in the volume of lung_L (ΔLVL) and the difference in the mean dose (ΔDmean) of lung_L under the DIBH and FB plans, the correlation between the difference in the heart-chest distance (ΔHCD) and the ΔDmean of the heart,LAD under the DIBH and FB plans.ResultsThe D-VMAT plan lower lung_L V5 than both the F-IMRT and F-VMAT plans (p&lt;0.05), The D-VMAT plan lower values for V10, V20, V30, and Dmean than did the other plans (p &lt; 0.05). For the heart, the D-VMAT plan lower V5, V10, V20, and Dmean values than did the other plans (p &lt; 0.05). The D1% and Dmax of the heart and the Dmax and Dmean of the LAD obtained with the D-VMAT plan were lower than those obtained with the F-IMRT and F-VMAT plans (p &lt; 0.05). ΔHCD exhibited correlation with the ΔDmean of the LAD between the D-VMAT and F-IMRT plans and between the D-VMAT and F-VMAT plans (R = -0.765 and -0.774, respectively, p = 0.000).Conclusionthe D-VMAT plan offered enhanced protection for OARs. The integration of the DIBH technique with half-field and VMAT technology in the D-VMAT plan offers a superior dose distribution.
Late radiation-related lymphopenia after prostate stereotactic body radiation therapy plus or minus supplemental pelvic irradiation
Authors: Gaudian Kelly , Koh Min Jung , Koh Min Ji , Jermain Peter , Khan Irfan , Kallam Diya , Lee Zach , Collins Ryan R. , Zwart Zoya , Danner Malika , Zwart Alan , Kumar Deepak , Atkins Michael B. , Suy Simeng , Collins Sean P. 
Published: November 2024

IntroductionPrior studies suggest lymphopenia following radiation therapy may impact toxicity and cancer control. Chronic radiation-related lymphopenia (RRL) has been noted in prostate cancer patients treated with conventionally fractionated pelvic radiation therapy. The impact of utilizing hypofractionated high integral dose therapies such as stereotactic body radiation therapy (SBRT) on RRL is less well characterized. This prospective study sought to evaluate the impact of prostate SBRT plus or minus supplemental pelvic nodal radiation (PNI) on RRL.MethodsBetween 2012 and 2023, serial serum absolute lymphocyte counts (ALCs) were measured in 226 men treated at MedStar Georgetown with robotic SBRT using the CyberKnife® (CK) (36.25 Gy in 5 fractions) alone or CK (19.5 Gy in 3 fractions) followed by supplemental PNI using VMAT (37.5–45.0 Gy in 15–25 fractions) per an institutional protocol (IRB#: 2012-1175). Baseline ALC (k/μL) was measured 1–2 hours prior to robotic SBRT and at each follow-up appointment (1, 3, 6, 9, 12, 18, and 24 months post-treatment). Lymphopenia was graded using the CTCAEv.4: Grade 1 (0.8-1.0 k/μL), Grade 2 (0.5-0.8 k/μL), Grade 3 (0.2-0.5 k/μL) and Grade 4 (&lt;0.2 k/μL). To compare two different treatment groups, the Wilcoxon signed-rank test was used. A p-value of &lt; 0.05 determined statistical significance.ResultsOf 226 patients (SBRT alone: n = 169, SBRT + PNI: n = 57), the median age was 72 years and 45% of patients were non-white. Baseline lymphopenia was uncommon and of low grade. In the SBRT alone group, the baseline ALC of 1.7 k/μl decreased by 21% to 1.4 k/μL at 3 months and then stabilized. 38% of these men experienced lymphopenia in the two years following SBRT, however, no patient presented with Grade 3 lymphopenia. Patients who received SBRT + PNI had a lower baseline ALC (1.5 k/μl), and a significantly greater decrease in ALC relative to individual baseline value throughout the 2-year follow-up period, decreasing by 57% to 0.6 k/μL at 3 months and recovering to a 36% decrease from baseline (1.0 k/μL) at 24 months. Notably, 12% of the men treated with SBRT + PNI experienced Grade 3 lymphopenia. No patient in either cohort experienced Grade 4 lymphopenia.DiscussionThe low incidence of high-grade lymphopenia within this elderly patient population further supports the safety of prostate SBRT plus or minus PNI for the treatment of prostate cancer. However, RRL was more severe when PNI was utilized. The effect of SBRT and PNI on lymphocytes in prostate cancer patients could act as a model for other cancers, specifically those involving treatment with immunomodulatory agents. Future studies should focus on the clinical implications of RRL and the effects of specifically irradiating lymphoid tissues on lymphocyte biology.
Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment
Authors: Gao Ming , Li Jie , Han Xu , Zhang Beiyao , Chen Jinting , Lang Jiadong , Zhang Qiangqiang 
Published: November 2024

IntroductionDiabetic cognitive impairment(DCI) presents as a central nervous complication of diabetes especially among aging population. Melatonin (MEL) is known for its antioxidant and anti-inflammation effects in neuroprotective aspects. Recent evidence has demonstrated that the gut microbiome plays a key role in DCI by modulating cognitive function through the gut–brain crosstalk. MEL has been shown to modulate gut microbiota composition in diabetic model. However, the underlying mechanism through which the gut microbiome contributes to DCI remains unclear. This study aims to investigate the effect and mechanism of MEL in attenuating DCI in relation to regulating the gut microbiome and metabolomics.MethodsCognitive and memory function were assessed by the Morris water maze test, histopathological assessment of brain tissues, and immunoblotting of neuroinflammation and apoptosis. The levels of serum tumor necrosis factor-α (TNF-α) and Interleukin-18 (IL-18) were measured by enzyme-linked immunoassays to reflect the circulatory inflammation level.16S rRNA microbiome sequencing analysis was performed on control mice(db-m group), diabetic mice(db-db group) and MEL-treated diabetic mice(db-dbMEL group). Gut metabolites changes were characterized using liquid chromatography tandem mass spectrometry (LC-MS/MS).ResultsOur study confirmed that MEL alleviated diabetes-induced cognition and memory dysfunction. MEL protected against neuroinflammation and apoptosis in hippocampus of db-db mice. MEL corrected the increased abundance of Bacteroides and Dorea and the reduced abundance of Prevotella in db-db mice. The vast majority of differential metabolites among the three groups were lipids and lipid-like molecules. MEL significantly restored the reduced levels of pyruvate and lactic acid.DiscussionOur results supported the use of MEL as a promising therapeutic agent for DCI, in which the underlying mechanism may be associated with gut microbiome and metabolomics regulation.
Evolutionary analysis of TIR- and non-TIR-NBS-LRR disease resistance genes in wild strawberries
Authors: Zhu Ni , Feng Yuxi , Shi Guangxin , Zhang Qihang , Yuan Bo , Qiao Qin 
Published: November 2024

IntroductionNBS-LRR genes (NLRs) are the most extensive category of plant resistance genes (R genes) and play a crucial role in pathogen defense. Understanding the diversity and evolutionary dynamics of NLRs in different plant species is essential for improving disease resistance. This study investigates the NLR gene family in eight diploid wild strawberry species to explore their structural characteristics, evolutionary relationships, and potential for enhancing disease resistance.MethodsWe conducted a comprehensive genome-wide identification and structural analysis of NLRs across eight diploid wild strawberry species. Phylogenetic analysis was performed to examine the relationships between TIR-NLRs (TNLs), Non-TIR-NLRs (non-TNLs), CC-NLRs (CNLs), and RPW8-NLRs (RNLs). Gene structures were compared, and gene expression was profiled across different NLR subfamilies. Additionally, in vitro leaf inoculation assays with Botrytis cinerea were performed to assess the resistance of various strawberry species.ResultsOur analysis revealed that non-TNLs constitute over 50% of the NLR gene family in all eight strawberry species, surpassing the proportion of TNLs. Phylogenetic analysis showed that TNLs diverged into two subclades: one grouping with CNLs and the other closely related to RNLs. A significantly higher number of non-TNLs were under positive selection compared to TNLs, indicating their rapid diversification. Gene structure analysis demonstrated that non-TNLs have shorter gene structures than TNLs and exhibit higher expression levels, particularly RNLs. Notably, non-TNLs showed dominant expression under both normal and infected conditions. In vitro leaf inoculation assays revealed that Fragaria pentaphylla and Fragaria nilgerrensis, which have the highest proportion of non-TNLs, exhibited significantly greater resistance to Botrytis cinerea compared to Fragaria vesca, which has the lowest proportion of non-TNLs.DiscussionThe findings of this study provide important insights into the evolutionary dynamics of NLRs in strawberries, particularly the significant role of non-TNLs in pathogen defense. The rapid diversification and higher expression levels of non-TNLs suggest their potential contribution to enhanced disease resistance. This research highlights the value of non-TNLs in strawberry breeding programs aimed at improving resistance to pathogens such as Botrytis cinerea.
The influence of transportation, social norms, cultural identity, and affective disposition in transnational media enjoyment
Authors: Wang Jing , Ye Qiqi , Shuai Zhiqiang , Wang Peifeng , Wang Yujie , Lin Changqing 
Published: November 2024

BackgroundThe globalization of the media market is forcing decision-makers to understand the psychological processes behind local audiences’ enjoyment of foreign TV dramas. Transportation is a well-established psychological theory and framework utilized to elucidate and anticipate audience engagement and enjoyment in the cognitive process of experiencing a narrative text. Although there is a substantial body of literature on transportation and media enjoyment, there is a noticeable absence of studies on the relationship between audiences being “transported” into the narrative world of TV dramas and, particularly, the pleasure audiences derive from interacting with media content within a cross-cultural acceptance context.MethodThe research employs a quantitative design, with responses collected from 353 students enrolled at a Malaysian public university. It aims to validate the influence of social norms, cultural identity, and affective disposition on narrative immersion while watching foreign TV dramas, as well as the subsequent enjoyment of media among local audiences.ResultsThe results indicate that social norms, cultural identity, and affective disposition significantly influence transportation and enjoyment. Furthermore, the influence of cultural identity on social norms has a positive moderating effect on transportation.DiscussionStorytelling that complies with social norms while offering new perspectives can maximally engage audiences, potentially altering their narrative cognition and deepening their immersion in fictional narratives. Cultural identity can shape audience perceptions and reactions to cross-cultural media consumption, ultimately influencing the degree to which audiences are drawn into the narrative. Furthermore, the audience’s emotional connection to characters in the narrative or to situations in the drama significantly influences the overall cognitive and immersion levels.
Impact of cognitive biases on environmental compliance risk perceptions in international construction projects
Authors: Chang Tengyuan , Du Yuxuan , Deng Xiaopeng , Wang Xianru 
Published: November 2024

IntroductionThis research explores the complex interplay between cognitive biases and Environmental Compliance Risk Perception (ECRP) in international construction projects. Understanding such a relationship is essential as it can have significant implications for the success and environmental sustainability of these projects.MethodsThis study analyzed a scenario-based questionnaire survey conducted with 270 international construction practitioners. It employed Partial Least Squares Structural Equation Modeling (PLS-SEM) to identify the influencing factors of cognitive biases and their impact on ECRP. The factors considered included individual, organizational, and project-specific aspects.ResultsThe analysis revealed that Cultural Bias (CuB), Confirmation Bias (CoB), and Short-Termism (ST) significantly influence ECRP. These biases are affected by a complex interplay of the aforementioned antecedents.DiscussionBased on the results, an innovative framework for evaluating ECRP was proposed. Additionally, a management strategy was developed to recognize and mitigate the cognitive biases of professionals during the bidding and execution phases of international construction projects. By clarifying the factors influencing cognitive biases and their complex relationship with ECRP, this research emphasizes the importance of addressing employee cognitive biases in conjunction with improving environmental awareness in environmental compliance management. It fills a crucial gap in the existing literature and offers international contractors strategies to reduce these biases, thereby enhancing their environmental protection capabilities and minimizing potential negative environmental impacts from international construction projects, which is vital for advancing sustainable development.