bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-Term Results of Endoscopic Percutaneous Longitudinal Tenotomy for Noninsertional Achilles Tendinopathy and the Presentation of a Simplified Operative Method
Authors: Chraim Michel , Alrabai Hamza M. , Krenn Sabine , Bock Peter , Trnka Hans-Jörg 
Published: July 2018

Purpose: This study was aimed to review the short-term results of endoscopic percutaneous longitudinal tenotomy for noninsertional Achilles tendinopathy using the Centerline Endoscopic Carpal Tunnel Release instrument (Arthrex). This method simplifies the operation technique, allows a good endoscopic visualisation of the Achilles tendon with very promising results. Methods: We performed multiple percutaneous longitudinal tenotomies under local anesthesia in 24 patients (25 tendons) with Achilles tendinopathy or peritendinitis that had failed conservative treatment between January 2013 and September 2016. All ambulatory procedures consisted of paratenon release and longitudinal tenotomies. The results were reviewed in 22 patients (23 tendons) at an average follow-up period of 22.5 months (range 10-36 months). Patients’ satisfaction and functional outcomes were evaluated using the Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaire, the pain visual analog scale (VAS), and the functional foot index. Results: Initial results are very promising with excellent results in 12 patients, good results in 9 patients, and fair result in 1 patient. One patient developed a postoperative thrombosis of the operated limb. Another patient developed a hypertrophic painful scar of the incision wound. The VAS for pain decreased drastically after the index procedure and averaged to 0.2 (SD 0.447). The VISA-A questionnaire score had improved from 42 ± 7.2 points preoperatively to 96.8 ± 14.3 points postoperatively (P = .004). The functional foot index decreased from 84 (SD 30.517) to 33.4 (SD 6.452) on the follow-up examination. Conclusions: The endoscopic-assisted longitudinal tenotomies procedure of the Achilles tendon is easily feasible and can be performed on an outpatient basis, produces minimal complications and shows excellent results. The described technique is recommended for all surgeons especially for those familiar with endoscopy of the Achilles tendon. Levels of Evidence: Therapeutic, Level IV: Case Series
Identification of a low frequency missense mutation in MUC6 contributing to pulmonary artery hypertension by whole‐exome sequencing
Authors: Zou Lihui , Li Wenqing , Han Jingli , Yang Yuanhua , Jin Junhua , Xiao Fei , Xu Xiaomao , Zhai Zhenguo 
Published: July 2018

Pulmonary arterial hypertension (PAH) represents a progressive disease characterized by abnormally high blood pressure in the pulmonary artery. Although mutations in the bone morphogenetic receptor 2 (BMPR2) are found in 80% of heritable, their low penetrance suggests that other unidentified genetic modifiers are required for this disease. In this report, whole‐exome sequencing (WES) and a linkage analysis were performed on genomic DNA isolated from four affected relatives and one non‐affected relative in two PAH families. By focusing on meaningful variants which were presented in the four affected family members, but not presented in the non‐affected individual, 49 SNP and eight indel variants in 39 genes were identified as candidates. Further high‐throughput multiplex genotyping and Sanger sequencing were carried out to confirm the putative causal mutations in 150 individuals (30 idiopathic PAH [IPAH] patients, 30 chronic thromboembolic pulmonary hypertension [CTEPH] patients, and 90 normal controls). A heterozygous and deleterious mutation in the gene MUC6 (p.Pro1716Ser) was confirmed in the IPAH group (20/30, 67%) and CTEPH group (1/30, 3.33%); no variant was detected in the 90 normal controls. MUC6, which is short for mucin 6, encodes high molecular weight glycoprotein produced by many epithelial tissues and forms an insoluble mucous barrier that protects the lumens. We re‐confirmed this low frequency mutation with the 1000 Genomes database across all species; no population or frequency data of this allele were acquired. We also found that this mutation site was highly conserved in different species and predicted MUC6 has the protection function of the airway and pneumoangiogram based on genomic sequence data. The compound heterozygous MUC6 gene mutation (p.Pro1716Ser) suggests a novel disease mechanism leading to PAH.
Development of the circumduction metric for identification of cervical motion impairment
Authors: Zhou Yue , Loh Eldon , Dickey James P , Walton David M , Trejos Ana Luisa 
Published: July 2018

Introduction Chronic neck pain results in considerable personal, clinical, and societal burden. It consistently ranks among the top three pain-related reasons for seeking healthcare. Despite its prevalence, neck pain is difficult to both assess and treat. Quantitative approaches are required since diagnostic imaging techniques rarely provide information on movement-related neck pain, and most common clinical assessment tools are limited to single plane motion measurement. Methods In this study, the ability of an inertial measurement unit to document the cervical motion characteristics of 28 people with chronic neck pain and 23 healthy controls was assessed. A total of six circumduction metrics and one neck circumduction trajectory model were proposed as identification metrics. Results Five metrics demonstrated significant differences between the two groups. The neck circumduction trajectory model successfully distinguished between the two groups. Discussion The evaluation of the proposed metrics provides proof of concept that novel metrics can be captured with relative ease in the clinical setting using an inexpensive wearable sensor headband. The derivation of the proposed model may open new lines of inquiry into the clinical utility of assessing the multiplanar movement of cervical circumduction. The results obtained from this study also provide additional insight for the development of a sensitive, quantifiable and real-world neck evaluation strategies.
Prevalence of Posttraumatic Stress Disorder Symptoms Among Young Athletes After Anterior Cruciate Ligament Rupture
Authors: Padaki Ajay S. , Noticewala Manish S. , Levine William N. , Ahmad Christopher S. , Popkin Michael K. , Popkin Charles A. 
Published: July 2018

Background: The risk of depression and the fear of reinjury were documented in recent investigations of patients after anterior cruciate ligament (ACL) ruptures. The extent of psychological trauma accompanying these injuries among young athletes, however, has never been assessed. Hypothesis: Posttraumatic stress disorder (PTSD) symptoms after ACL injury are present among young athletes with high athletic identities. Study Design Case series; Level of evidence, 4. Methods: Patients ≤21 years of age who had suffered an acute ACL rupture were consecutively recruited at a tertiary care center. Patients completed the Horowitz Impact of Event Scale - Revised (IES-R) to analyze for PTSD symptomatology, the Athletic Identity Measurement Scale, and an athlete specialization instrument created at the authors’ institution. Results: A total of 24 patients were consecutively recruited. The mean patient age was 14.5 ± 2.7 years, and 50% of patients were male. More than 87.5% of patients experienced avoidance symptoms, 83.3% acknowledged symptoms of intrusion, and 75% had symptoms of hyperarousal. Patients aged 15 to 21 years incurred a higher severity of PTSD symptoms than younger patients ( P = .033). Female patients experienced greater emotional trauma than male patients ( P = .017). Finally, patients with high athletic identities experienced greater emotional trauma than those with lesser athletic identities, but this finding was not statistically significant ( P = .14). Conclusion: Following ACL rupture, young athletes experience significant emotional trauma, including symptoms of avoidance, intrusion, and hyperarousal. High school and college athletes, female athletes, and patients with high athletic identities may be most susceptible.
From IIRIRA to Trump: Connecting the Dots to the Current US Immigration Policy Crisis
Authors: Kerwin Donald 
Published: July 2018

When signing into law the Illegal Immigration Reform and Immigrant Responsibility Act of 1996 (IIRIRA, or “the Act”), 1 President William J. Clinton asserted that the legislation strengthened “the rule of law by cracking down on illegal immigration at the border, in the workplace, and in the criminal justice system — without punishing those living in the United States legally” ( Clinton 1996 ). In fact, the Act has severely punished US citizens and noncitizens of all statuses. It has also eroded the rule of law by eliminating due process from the overwhelming majority of removal cases, curtailing equitable relief from removal, mandating detention (without individualized custody determinations) for broad swaths of those facing deportation, and erecting insurmountable, technical roadblocks to asylum. In addition, it created new immigration-related crimes and established “the concept of ‘criminal alienhood,’” which has “slowly, but purposefully” conflated criminality and lack of immigration status ( Abrego et al. 2017 , 695). It also conditioned family reunification on income, divided mixed-status families, and consigned other families to marginal and insecure lives in the United States ( Lopez 2017 , 246). Finally, it created the 287(g) program that enlists state and local law enforcement agencies in immigration enforcement and drives a wedge between police and immigrant communities. The trend of “cracking down” on immigrants did not begin with IIRIRA. The Anti-Drug Abuse Act of 1986, the Anti-Drug Abuse Act of 1988, and the 1990 Immigration Act, for example, expanded deportable offenses ( Abrego et al. 2017 , 697; Macías-Rojas 2018 , 3–4). IIRIRA, however, significantly “ratchet[ed] up” the “punitive aspects of US immigration law already in place” ( Abrego et al. 2017 , 702), and erected much of the legal and operational infrastructure that underlies the Trump administration’s plan to remove millions of undocumented residents and their families, to terrify others into leaving “voluntarily,” and to slash legal immigration. In 2016, the Center for Migration Studies of New York (CMS) issued a call for papers to examine IIRIRA’s multifaceted consequences. 2 Between March 2017 and January 2018, CMS published eight papers from this collection in its Journal on Migration and Human Security ( JMHS). The papers cover the political conditions that gave rise to IIRIRA, and the Act’s impact on immigrants, families, communities, and the US immigration system. This article draws on these papers — as well as sources closer to IIRIRA’s passage and implementation — to describe how the Act transformed US immigration policies and laid the groundwork for the Trump administration’s policies. 3 After a brief discussion of IIRIRA’s origins, the article discusses the law's effects and subsequent policies related to the growth of the US immigration enforcement apparatus, removal, asylum, detention, the criminal prosecution of immigrants, the treatment of immigrant families, and joint federal-state enforcement activities.
CALGB 50604: risk-adapted treatment of nonbulky early-stage Hodgkin lymphoma based on interim PET
Authors: Straus David J. , Jung Sin-Ho , Pitcher Brandelyn , Kostakoglu Lale , Grecula John C. , Hsi Eric D. , Schöder Heiko , Popplewell Leslie L. , Chang Julie E. , Moskowitz Craig H. , Wagner-Johnston Nina , Leonard John P. , Friedberg Jonathan W. , Kahl Brad S. , Cheson Bruce D. , Bartlett Nancy L. 
Published: July 2018

Key Points
Interim PET− nonbulky stage I/II patients had 3-year PFS of 91% with 4 ABVD cycles and no RT. Too few patients were interim PET+ to draw firm conclusions about efficacy of escalated BEACOPP plus involved-field RT.
Targeted therapy for fusion-driven high-risk acute leukemia
Authors: Pikman Yana , Stegmaier Kimberly 
Published: July 2018

Abstract
Despite continued progress in drug development for acute leukemias, outcomes for patients with some subtypes have not changed significantly in the last decade. Recurrent chromosomal translocations have long been recognized as driver events in leukemia, and many of these oncogenic fusions portend high-risk disease. Improved understanding of the molecular underpinnings of these fusions, coupled with novel chemistry approaches, now provide new opportunity for therapeutic inroads into the treatment of leukemia driven by these fusions.
MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML
Authors: Sanders Mathijs A. , Chew Edward , Flensburg Christoffer , Zeilemaker Annelieke , Miller Sarah E. , al Hinai Adil S. , Bajel Ashish , Luiken Bram , Rijken Melissa , Mclennan Tamara , Hoogenboezem Remco M. , Kavelaars François G. , Fröhling Stefan , Blewitt Marnie E. , Bindels Eric M. , Alexander Warren S. , Löwenberg Bob , Roberts Andrew W. , Valk Peter J. M. , Majewski Ian J. 
Published: July 2018

Key Points
The DNA glycosylase MBD4 acts as a safeguard against damage from 5mC deamination. Germ line MBD4 deficiency stimulates clonal hematopoiesis and guides the development of leukemia via recurrent mutations in DNMT3A.
Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study
Authors: Currow David C. , Smith Joanna M. , Chansriwong Phichai , Noble Simon I.R. , Nikolaidou Theodora , Ferreira Diana , Johnson Miriam J. , Ekström Magnus 
Published: July 2018

The aim of the study was to explore trajectories of breathlessness intensity by function and life-limiting illness diagnosis in the last 3 weeks of life in palliative care patients.A prospective, consecutive cohort study obtained point-of-care data of patients of Silver Chain Hospice Care Service (Perth, Australia) over the period 2011–2014 (n=6801; 51 494 data-points). Breathlessness intensity (0–10 numerical rating scale) and physical function (Australia-modified Karnofsky Performance Status (AKPS)) were measured at each visit. Time was anchored at death. Breathlessness trajectory was analysed by physical function and diagnosis using mixed effects regression.Mean±sdage was 71.5±15.1 years and 55.2% were male, most with cancer. The last recorded AKPS was >40 for 26.8%. Breathlessness was worst in people with cardiorespiratory disease and AKPS >40, and breathlessness in the last week of life increased most in this group (adjusted mean 2.92versusall others 1.51; p=0.0001). The only significant interaction was with diagnosis and function in the last week of life (p<0.0001).Breathlessness is more intense and increases more in people with better function and cardiorespiratory disease immediately before death. Whether there are reversible causes for these people should be explored prospectively. Omitting function from previous population estimates may have overestimated breathlessness intensity for many patients in the days preceding death.
Negative effects in psychotherapy: commentary and recommendations for future research and clinical practice
Authors: Rozental Alexander , Castonguay Louis , Dimidjian Sona , Lambert Michael , Shafran Roz , Andersson Gerhard , Carlbring Per 
Published: July 2018

BackgroundPsychotherapy can alleviate mental distress and improve quality of life, but little is known about its potential negative effects and how to determine their frequency.AimsTo present a commentary on the current understanding and future research directions of negative effects in psychotherapy.MethodAn anonymous survey was distributed to a select group of researchers, using an analytical framework known as strengths, weaknesses, opportunities and threats.ResultsThe researchers perceive an increased awareness of negative effects in psychotherapy in recent years, but also discuss some of the unresolved issues in relation to their definition, assessment and reporting. Qualitative methods and naturalistic designs are regarded as important to pursue, although a number of obstacles to using such methods are identified.ConclusionNegative effects of psychotherapy are multifaceted, warranting careful considerations in order for them to be monitored and reported in research settings and routine care.Declaration of interestNone.
An online survey of young adolescent girls' use of the internet and smartphone apps for mental health support
Authors: Grist Rebecca , Cliffe Bethany , Denne Megan , Croker Abigail , Stallard Paul 
Published: July 2018

BackgroundAdolescents are digital natives, with the majority now owning their own smartphones and having internet access. Although the internet and smartphone applications (apps) can provide mental health support, little is known about how young adolescents use digital technology for mental health purposes. There are many digital health resources available for young people, but the assumption that they will be open to use them has been largely untested.AimsWe aimed to explore how adolescents with and without raised symptoms of anxiety, depression and problematic eating use the internet on smartphones/tablets and mental health apps.MethodThe Bristol Online Survey tool was used to deliver an online survey to 775 girls aged 11–16 years, attending a state-funded secondary school in the south-west of England. The survey was completed in class during the winter term of 2017.ResultsA total of 98.7 and 97.4% used the internet and apps, respectively, although only 6% had used any mental health apps. Of those with raised mental health symptoms, 15–17% used or were using a mental health app, with 48.5% reporting that they would not use a mental health app.ConclusionsYoung female adolescents are avid users of the internet and apps but are not using digital technology for mental health purposes. Addressing concerns about digital technology are necessary to maximise the effect it can have on child and adolescent mental health.Declaration of interestNone.
Protocol and rationale for the first South Asian 5-year prospective longitudinal observational cohort study and biomarker evaluation investigating the clinical course and risk profile of IgA nephropathy: GRACE IgANI cohort
Authors: Alexander Suceena , John George T. , Korula Anila , Vijayakumar T. S. , David Vinoi George , Mohapatra Anjali , Valson Anna T. , Jacob Shibu , Koshy Pradeep Mathew , Rajan Gautam , John Elenjickal Elias , Matthai Smita Mary , Jeyaseelan L. , Ponnusamy Babu , Cook Terence , Pusey Charles , Daha Mohamed R. , Feehally John , Barratt Jonathan , Varughese Santosh 
Published: July 2018

Background:IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney disease. Unlike the slowly progressive course seen among Caucasian and East Asian subjects (actuarial survival 80-85% over 10 years), in India about 30-40% of patients have nephrotic syndrome and renal dysfunction at presentation and a 10-year renal survival of 35%, as reported from a retrospective registry. These observations cannot be entirely attributed to a lack of uniform screening protocols or late referral and attest to the probability that IgAN may not be the same disease in different parts of the world.Methods:We will prospectively recruit 200 patients with IgAN (the GRACE IgANI—GlomerularResearchAndClinicalExperiments-IgANephropathy inIndians—cohort) and stratify them into low and high risk of progression based on published absolute renal risk scores. We will test the validity of this risk score in an unselected Indian IgAN population over a 5-year follow-up period. In parallel, we will undertake extensive exploratory serum, urine, renal and microbiome biomarker studies, firstly, to determine if the underlying pathogenic pathways are the same in Indian IgAN compared to those reported in Caucasian and East Asian IgAN. Secondly, we will systematically assess the value of measuring selected biomarkers and adding this data to traditional measures of risk in IgAN to predict kidney failure. We ultimately hope to generate a composite IgAN risk score specific for the Indian population.Ethics and data dissemination:Approval was obtained from the Institutional Review Board (Silver, Research and Ethics Committee) of the Christian Medical College, Vellore, India (Ref. No. IRB Min. No. 8962 [Other] dated 23.07.2014 and IRB Min. No. 9481 [Other] dated 24.06.2015). It is anticipated that results of this study will be presented at national and international meetings, with reports being published from late 2018.
PENGARUH SUMBER PUPUK ORGANIK TERHADAP PENAMPILAN TEBU (Saccharum officinarum L.) PADA TATA TANAM BARIS GANDA BENIH GANDA
Authors: Busro Djumali , Mulyaningsih Sri , Basuki Teger 
Published: July 2018

Increased productivity of sugarcane in upland area can be done through the implementation of the integration of manure with a high dose of inorganic fertilizer in the double rows and twice plant populations of single row (“double rows double seeds”) planting arrangement. Limited availability of manure and inorganic fertilizer entails the replacement of manure with green manure fertilizer. The research was aimed to obtain a green manure as replacement manure that can be intercropped in the double rows double seeds planting arrangement. The experiment was done in the Asembagus Experimental Station, Situbondo, East Java on January to December 2014 for plant cane (PC) and from January to December 2015 for ratoon cane (RC). Treatments were arranged in a Randomized Block Design time for replication. The treatment includes (1) the four rows of Crotalaria juncea, (2) two rows of Crotalaria juncea, (3) four rows of peanuts in width between rows of sugar cane, (4) manure, and (5) no organic fertilizer. The results showed that the integration of organic fertilizer with a low dose of inorganic fertilizers increases productivity and sugar yield 5.20 to 41.78% and 33.33 to 69.90%, respectively in PC and 7.33 to 32.67% and 5.74 to 29.61%, respectively in RC from no organic fertilizer. Four rows of Crotalaria juncea could replace the role of manure in improving the productivity and sugar yield for PC and two rows of Crotalaria juncea for RC.
Psychometric analysis of Epworth Sleepiness Scale and its correlation with Pittsburgh sleep quality index in poor sleepers among Indian university students
Authors: Veqar Zubia , Hussain M. Ejaz 
Published: July 2018

Abstract

Background
The Epworth Sleepiness Scale (ESS) is an 8-item scale to detect excessive daytime sleepiness. Although its psychometric properties are well established on a number of populations the same has not been done for an Indian population, hence this study was designed to cover this knowledge gap.

Aims
The purpose of this study was to establish the test-retest reliability, validity and internal consistency of the ESS and its correlation with the Pittsburgh Sleep Quality Index (PSQI) in poor sleepers in India.

Materials and methods
Twenty-five poor sleepers were randomly chosen from a university population. All the subjects were administered the two scales on the test day and the same was repeated after 1 week, which was the retest.

Statistical analysis
Intraclass coefficient (ICC) and standard error of measurement (SEM) were calculated for the reliability which was further supported by the Bland-Altman graph and a scatterplot. Cronbach’s alpha and Pearson’s coefficient were calculated for internal consistency and correlation, respectively.

Results
Twenty-five poor sleepers with mean age 25.24 ± 7.04 years were recruited. The test-retest reliability for ESS displayed good reliability (ICC2,1: 0.86) which was supported by the Bland-Altman graph and the scatterplot. Cronbach’s alpha was reported as 0.86 and Pearson’s coefficient was r: 0.62, p-value: 0.001.

Conclusion
The results suggest that the ESS has good internal consistency and test-retest reliability for a university population of poor sleepers in India.