bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of proangiogeneic factors in pressure-overload left-ventricular hypertrophy results in inadequate capillary growth
Authors: Zeriouh Mohamed , Sabashnikov Anton , Tenbrock Arne , Neef Klaus , Merkle Julia , Eghbalzadeh Kaveh , Weber Carolyn , Liakopoulos Oliver J. , Deppe Antje-Christin , Stamm Christof , Cowan Douglas B. , Wahlers Thorsten , Choi Yeong-Hoon 
Published: May 2019

Background: Pressure-overload left-ventricular hypertrophy (LVH) is an increasingly prevalent pathological condition of the myocardial muscle and an independent risk factor for a variety of cardiac diseases. We investigated changes in expression levels of proangiogeneic genes in a small animal model of LVH. Methods: Myocardial hypertrophy was induced by transaortic constriction (TAC) in C57BL/6 mice and compared with sham-operated controls. The myocardial expression levels of vascular endothelial growth factor (VEGF), its receptors (KDR and FLT-1), stromal-cell-derived factor 1 (SDF1) and the transcription factors hypoxia-inducible factor-1 and 2 (HIF1 and HIF2) were analyzed by quantitative polymerase chain reaction over the course of 25 weeks. Histological sections were stained for caveolin-1 to visualize endothelial cells and determine the capillary density. The left-ventricular morphology and function were assessed weekly by electrocardiogram-gated magnetic resonance imaging. Results: The heart weight of TAC animals increased significantly from week 4 to 25 ( p = 0.005) compared with sham-treated animals. At 1 day after TAC, the expression of VEGF and SDF1 also increased, but was downregulated again after 1 week. The expression of HIF2 was significantly downregulated after 1 week and remained at a lower level in the subsequent weeks. The expression level of FLT-1 was also significantly decreased 1 week after TAC. HIF-1 and KDR showed similar changes compared with sham-operated animals. However, the expression levels of HIF1 after 4 and 8 weeks were significantly decreased compared with day 1. KDR changes were significantly decreased after 1, 2, 4, 8 and 25 weeks compared with week 3. After 4 weeks post-TAC, the size of the capillary vessels increased ( p = 0.005) while the capillary density itself decreased (TAC: 2143 ± 293 /mm2 versus sham: 2531 ± 321 /mm2; p = 0.021). Starting from week 4, the left-ventricular ejection fraction decreased compared with controls ( p = 0.049). Conclusions: The decrease in capillary density in the hypertrophic myocardium appears to be linked to the dysregulation in the expression of proangiogeneic factors. The results suggest that overcoming this dysregulation may lead to reconstitution of capillary density in the hypertrophic heart, and thus be beneficial for cardiac function and survival.
Effectiveness of the golimumab educational program in ensuring healthcare professionals’ awareness of risks described in the European risk management plan
Authors: Felo Lauren , Otero-Lobato Marijo , Geldhof Anja , Noël Wim 
Published: May 2019

Background: The golimumab safety awareness study commenced in 2010 to measure, periodically, the awareness of golimumab prescriber healthcare professionals (HCPs) of specific risks associated with golimumab as well as awareness of the requirement to provide a patient alert card to each patient treated with golimumab, as described in the European golimumab educational program. The aim of this study was to measure the awareness of HCPs who prescribe or who intend to prescribe SIMPONI® (golimumab) of the risks potentially related to golimumab and of the requirements for distributing the patient alert card, as described in the golimumab educational program. Methods: A structured, quantitative Web-based survey was conducted in 2010, 2012, 2014, and 2016 in eight European countries among HCPs who were at that time current or future prescribers of golimumab for patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, nonradiographic axial spondyloarthritis, or ulcerative colitis. Results: The overall golimumab risk awareness was high for golimumab prescriber HCPs across the risk statement categories (median awareness in 2016 across categories: 91%). The awareness of the golimumab risks was generally slightly higher among rheumatologists (75–98%) and gastroenterologists (73–97%) than among dermatologists (67–94%). Overall, the awareness of the requirements for handing out the patient alert card to golimumab-treated patients remained steady or increased slightly in 2016 relative to the other surveys. Conclusions: The results of this study show that the awareness of risks associated with golimumab by golimumab prescriber HCPs is high. The information made available to golimumab prescriber HCPs appears to have been sufficient with respect to golimumab risk awareness education.
Comprehensive Hip Fracture Care Program: Successive Implementation in 3 Hospitals
Authors: Jackson Kelly , Bachhuber Mary , Bowden Dawn , Etter Katherine , Tong Cindy 
Published: May 2019

Introduction: Hip fractures are common and costly in the elderly population, often contributing to loss of function and independence. Prompt, coordinated surgical care may improve clinical and economic outcomes for this population. Materials and Methods: We created an interdisciplinary care program focused on minimizing time spent immobilized awaiting surgery and streamlining the care pathway for hip fracture. Patients older than 65 years with any hip fracture type including hip fracture repair Diagnosis-Related Group codes (MS-DRG 480, 481, or 482) and MS-DRG 469 and 470 with a hip fracture diagnosis were included in the study. The Hip Fracture Care program (HFCP) was implemented on a staggered basis in 3 hospitals in the HonorHealth system. Time to surgery, length of stay, and discharge location (home/skilled nursing facility) were compared pre- and post-intervention, utilizing an interrupted time series analysis to account for background trends. Results: More than 2000 patients across the 3 facilities received HFCP care; demographics were similar for the 826 patients serving as the pre-implementation comparison group. Mean (standard deviation [SD]) length of stay decreased from 5.6 (4.0) to 4.7 (2.9) days (mean difference 0.9 days; P < .05). Mean (SD) time from admission to the operating room decreased from 30.8 (21.1) to 25.6 (20.5) hours (mean difference 5.2 hours; P < .05). There was no change in the proportion of patients discharged to home versus skilled nursing facility. Discussion: Optimal care of this vulnerable population can significantly reduce the time to surgery and length of stay. Conclusions: Length of stay was reduced by nearly 1 day with implementation of a multifactorial program for hip fracture care.
The Empires Write Back: The Language of Postcolonial Nigerian Literature and the United States of America
Authors: Hallemeier Katherine 
Published: May 2019

Abstract
This article argues that reading for the vernacular of Standard American English in Nigerian Anglophone literature creates the opportunity to think about how the Englishes of British and American empire have not always been negotiated as singular or sequential, either in postcolonial or global Anglophone world literature. Writing by Buchi Emecheta, Chinua Achebe, and Chimamanda Ngozi Adichie suggests how the appropriation of the language of British colonization has been undercut and abetted by the Anglophone cultural and educational institutions of US empire.
On the Borders of Free Verse: Translating Varlam Shalamov’s Aesopian Texts
Authors: Larson K. Maya 
Published: May 2019

Abstract
Designed to deceive some readers, such as the censor, while inviting others to read “between the lines,” Aesopian texts task their translator with added interpretive complexity. Does a given translation reflect both text and subtext, target audience and hurdle audience? Is the target audience of the translated text even mappable onto an original text’s schema of hurdle and target audiences? The writings of Varlam Shalamov further complicate the translation of Aesopian texts. Whereas Leona Toker and others identify Aesopian moments in Shalamov’s prose, Svetlana Boym argues that in his writings the deceptive device of mimicry resists totalitarianism precisely when it goes beyond any Aesopian or other useful purpose. Shalamov’s 1963 essay “The National Borders of Poetry and Free Verse” (“Natsial’nye granitsy poezii i svobodnyi stikh”) invites engagement as an exemplary Aesopian text—one whose “deceptive means,” however, call for a more capacious understanding of Aesopian language. Nineteenth-century satirist Mikhail Saltykov-Shchedrin first used the term “Aesopian” to indicate the “trembling” littérateur’s unique style of writing, whose “deceptive means” showed “a remarkable resourcefulness in their invention.” The Aesopian mimicry of Shalamov’s essay on free verse exceeds both predator’s and trembling prey’s powers of appreciation, calling for equally artful mimicry on the part of the translator.
Rhyme in European Verse: A Case for Quantitative Historical Poetics
Authors: Maslov Boris , Nikitina Tatiana 
Published: May 2019

Abstract
Building on statistical approaches to poetic meter, this article puts forward a new quantitative method for exploring syllabo-accentual verse that takes into account several formal properties, including rhythm, rhyming, and stanzaic architecture. Against the background of a broad typology of European verse, it argues that a basic compensatory mechanism balancing different levels of organization of verse is complicated by the interaction between different national traditions. As a particularly complex case the article investigates the introduction of syllabo-accentual verse in Russia in the 1730s–40s, which represented an encounter between Polish, German, and French practices of versification. In addition to the general compensatory principle and local effects of borrowing, the article discusses a previously unexplored kind of formal complexity that evolves with the maturation of a tradition of verse making: certain nontrivial correlations between rhythm and rhyme that have been observed in Pushkin are not found in the work of Lomonosov, a poet who stands at the origin of Russian syllabo-accentual verse. The article’s conclusion addresses the relevance of the quantitative approach to the larger theoretical claims of Historical Poetics.
Relational Contracts, Multiple Agents, and Correlated Outputs
Authors: Kvaløy Ola , Olsen Trond E. 
Published: May 2019

We analyze relational contracts between a principal and a set of risk-neutral agents whose outputs are correlated. When only the agents’ aggregate output can be observed, a team incentive scheme is shown to be optimal, where each agent is paid a bonus for aggregate output above a threshold. We show that the efficiency of the team incentive scheme depends on the way in which the team members’ outputs are correlated. The reason is that correlation affects the variance of total output and thus, the precision of the team’s performance measure. Negatively correlated contributions reduce the variance of total output, and this improves incentives for each team member in the setting that we consider. This also has implications for optimal team size. If the team members’ outputs are negatively correlated, more agents in the team can improve efficiency. We then consider the case where individual outputs are observable. A tournament scheme with a threshold is then optimal, where the threshold depends on an agent’s relative performance. We show that correlation affects both the efficiency and design of the optimal tournament scheme. This paper was accepted by Shivaram Rajgopal, accounting.
Plasma and dried blood spot lysosphingolipids for the diagnosis of different sphingolipidoses: a comparative study
Authors: Polo Giulia , Burlina Alessandro P. , Ranieri Enzo , Colucci Francesca , Rubert Laura , Pascarella Antonia , Duro Giovanni , Tummolo Albina , Padoan Andrea , Plebani Mario , Burlina Alberto B. 
Published: May 2019

Abstract

Background
Lysosphingolipids, the N-deacylated forms of sphingolipids, have been identified as potential biomarkers of several sphingolipidoses, such as Gaucher, Fabry, Krabbe and Niemann-Pick diseases and in GM1 and GM2 gangliosidoses. To date, different methods have been developed to measure various lysosphingolipids (LysoSLs) in plasma. Here, we present a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for a simultaneous quantification of LysoSLs (HexSph, LysoGb3, LysoGM1, LysoGM2, LysoSM and LysoSM509) in dried blood spot (DBS). This LC-MS/MS method was used to compare the levels of LysoSLs in DBS and plasma in both affected patients and healthy controls.

Methods
Lysosphingolipids were extracted from a 3.2 mm diameter DBS with a mixture of methanol:acetonitrile:water (80:15:5, v/v) containing internal stable isotope standards. Chromatographic separation was performed using a C18 column with a gradient of water and acetonitrile both with 0.1% formic acid in a total run time of 4 min. The compounds were detected in the positive ion mode electrospray ionization (ESI)-MS/MS by multiple reaction monitoring (MRM).

Results
The method was validated on DBS to demonstrate specificity, linearity, lowest limit of quantification, accuracy and precision. The reference ranges were determined in pediatric and adult populations. The elevated levels of LysoSLs were identified in Gaucher disease (HexSph), Fabry disease (LysoGb3), prosaposin deficiency (HexSph and LysoGb3) and Niemann-Pick disease types A/B and C (LysoSM and LysoSM509). The correlation in the levels between DBS and plasma was excellent for LysoGb3 and HexSph but poor for LysoSM and LysoSM509.

Conclusions
Despite the fact that plasma LysoSLs determination remains the gold standard, our LC-MS/MS method allows a rapid and reliable quantification of lysosphingolipids in DBS. The method is a useful tool for the diagnosis of different sphingolipidoses except for Niemann-Pick type C.
Reinterpretation of Civilization
Authors: Wang Rui , Zhang Jie 
Published: May 2019

Abstract
The interpretation of civilization has always been controversial, and it is even difficult for academic circles to distinguish between civilization and culture. Researchers often use the method of scientific induction to generalize and define civilization from their respective angles. In fact, the concept of civilization is very complicated and difficult to explain from a single perspective. This article attempts to explore the multiple interpretations of civilization from the forward and reverse interaction of civilization development, different perspectives of civilization interpretation such as history, literature, and language, and the problem consciousness of civilization interpretation. From the perspective of history, civilization is formed by a series of specific historic events and social changes. From that of literature, civilization transcends specific historical events, is formed in the process of replacing old and new societies, and is of universal significance. Interpreted from the perspective of language signs, civilization is only an expression of human language signs, which are carriers of civilization, etc. As human society continues to develop, the interpretation of civilization continues to change. The meaning of civilization cannot be determined. We can only approach it through constant questioning and exploration. Because the understanding of civilization is multi-perspective, the interpretation of civilization is dynamic.
Education, Signs, and the History of Ideas
Authors: Olteanu Alin , Campbell Cary 
Published: May 2019

Abstract
This interview/dialogue addresses an important issue of how educational semiotics is grounded in the history of ideas. The discussions concern the shared history of semiotics and liberal education; the modern university and its medieval antecedents; semiotic consciousness, the traces of which are found in both Christianity and Islam (and the hermeneutics of Abrahamic and mystical religions, in general); intercultural translation; the relationship between learning (conceptualized edusemiotically) and biosemiotics, and how our social understandings of learning determine and shape our basic relationship to the world. Touching on the concepts of scaffolding and evolution, the chapter discusses adaptation in relation to learning, social semiotics and contemporary social reality, while imploring us to consider education in terms of its service to learning (and not the other way around).
Campbell: This interview was originally published as a recorded podcast-interview in 2017, on philosophasters.org as part of the interview series Signs of Life. Thank you to Thomas Hoeller for recording and editing the sound and music, and Marion Benkaiouche for transcribing the interview. Thank you, Inna Semetsky, for summarizing the dialogue, included in part in the above abstract description. Please bear in mind that as this interview was conducted two years ago, the author´s current ideas on some of these topics may have changed.
More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels
Authors: Chen Lingye , König Benjamin , Liu Tianbao , Pervaiz Sumaira , Razzaque Yasmin S. , Stauber Tobias 
Published: May 2019

Abstract
The volume-regulated anion channel (VRAC) is a key player in the volume regulation of vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and potentially other cues and releases chloride and organic osmolytes, which contributes to regulatory volume decrease (RVD). A plethora of studies have proposed a wide range of physiological roles for VRAC beyond volume regulation including cell proliferation, differentiation and migration, apoptosis, intercellular communication by direct release of signaling molecules and by supporting the exocytosis of insulin. VRAC was additionally implicated in pathological states such as cancer therapy resistance and excitotoxicity under ischemic conditions. Following extensive investigations, 5 years ago leucine-rich repeat-containing family 8 (LRRC8) heteromers containing LRRC8A were identified as the pore-forming components of VRAC. Since then, molecular biological approaches have allowed further insight into the biophysical properties and structure of VRAC. Heterologous expression, siRNA-mediated downregulation and genome editing in cells, as well as the use of animal models have enabled the assessment of the proposed physiological roles, together with the identification of new functions including spermatogenesis and the uptake of antibiotics and platinum-based cancer drugs. This review discusses the recent molecular biological insights into the physiology of VRAC in relation to its previously proposed roles.
Humor production in long-term romantic relationships: What the lack of moderation by sex reveals about humor’s role in mating
Authors: Hall Jeffrey A. 
Published: May 2019

AbstractThis manuscript explores whether the associations between partner humor production and relationship satisfaction and humor’s importance in romantic relationships are moderated by sex. Study 1 reports a meta-analysis (k = 10;N = 2,167) of the association between partner humor production (i.e., perceived; partner effects) and relationship satisfaction, and whether associations were moderated by participant sex. Contrary to predictions, partner humor production was more strongly associated to men’s relationship satisfaction than women’s satisfaction. Study 2 surveyed pairs of romantic partners (N = 246) regarding their production of humor, their appreciation of partner humor, and the importance of humor in their relationship. Results indicated no moderations by sex in the association between partner humor production and humor’s importance in the relationship.
Diversity and size-structured persistence of tropical carnivores in a small, isolated protected area
Authors: Mohd-Azlan Jayasilan , Kaicheen Sally Soo , Lok Lisa , Brodie Jedediah F. 
Published: May 2019

Abstract
Protected areas are critical to biodiversity conservation. Yet many protected areas around the world are very small, and population persistence can be compromised in small habitat patches, particularly for large species. But we do not know how small is too small for long-term population viability, or the degree to which habitat area effects vary with mammal body size, for most tropical species. Here, diversity and species occurrence were assessed in a small national park that has long been isolated from other forest patches. The two largest Bornean carnivores, the Sunda clouded leopard (Neofelis diardi) and sun bear (Helarctos malayanus), may be locally extinct, but 12 smaller carnivores appear to be persisting. The banded civet (Hemigalus derbyanus), the Malay civet (Viverra tangalunga) and the leopard cat (Prionailurus bengalensis) had relatively high occurrence rates and were found in all habitat types, though were more common in hill (banded civet) or lowland (common palm civet) forest (LF). Occurrence probabilities for all of these species and the common palm civet (Paradoxurus hermaphroditus) were lower in areas more accessible to humans. Detection rates and estimated diversity suggest that this park has a small carnivore assemblage equivalent to those of much larger areas. These are the first results demonstrating size-specific vulnerability to area effects in Southeast Asian carnivores.
Struggling for Control
Authors: Clemens Iris 
Published: May 2019

Abstract
Beim Navigieren in sozialen Gefügen ist Unsicherheit keine Ausnahme, sondern im Gegenteil der Normalfall, so die These des Beitrags. Anhand der modernen Netzwerktheorie von Harrison C. White, einem ihrer derzeit prominentesten Vertreter, wird dies mit Hilfe der netzwerktheoretischen Theoriemodule der Einbettung, des Wechselns und der Netzwerk- Domänen skizziert. Die Netzwerktheorie als die Theorie des Dazwischen zeigt auf, wie Menschen unentrinnbar in kontinuierlichen, hoch störanfälligen und diffizilen „dances in identity and control“ verstrickt sind.
Vom Erröten
Authors: Althans Birgit 
Published: May 2019

Abstract
Der Text untersucht das körperliche Phänomen des Errötens als codiertes Zeichen der Unsicherheit. Er beginnt mit dem therapeutischen Umgang mit dem Erröten und seiner medizinischen Klassifikation im 21. Jahrhundert, um sich dann mit seiner literarischen Konstruktion und Codierung als weibliche Strategie, als Umgang mit Wissen und Nicht-Wissen im 18. und 19. Jahrhundert (Defoe, Richardson, Rousseau, Austen) zu beschäftigen. Der Text endet mit einem literarischen Beispiel des männlichen Errötens (Wilder).