bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘All these things don’t take the pain away but they do help you to accept it’: making the case for compassion-focused therapy in the management of persistent pain
Authors: Gooding Hannah , Stedmon Jacqui , Crix Doug 
Published: June 2019

Background:People with persistent pain are frequently offered a pain management programme (PMP) as part of their care plan. Cognitive behavioural therapy (CBT) principles often underpin PMPs and has a good evidence base; nevertheless, more recent systematic reviews have suggested that its effectiveness is limited. Compassion-focused therapy (CFT) is a form of ‘third-wave CBT’ that offers an alternative and complementary view of pain, encouraging the person to be alongside their experience of pain and respond to it using skills of compassion they have learnt.Method:The current research explored the effectiveness of a 12-week CFT group for people who experience persistent pain. Research interviews explored CFT members’ experiences of the CFT group. Feedback was collected on the facilitators’ experience of running the group and questionnaire data collected on participants’ mood, pain disability, acceptance of chronic pain and levels of self-criticism and self-reassurance.Results:Interviews were analysed using interpretative phenomenological analysis that revealed five master superordinate themes representative across all interviews. These were then triangulated with data from the questionnaires and facilitator feedback.Conclusion:In people whose persistent pain was compounded by a significant psychological component, a CFT group approach helped reduce feelings of isolation, improve ability to self-reassure, learn new ways of coping and develop a growing acceptance of the limitations associated with their pain. The possible implications for future clinical practice are considered.
RETRACTED ARTICLE: Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1
Authors: Cao Xiaocheng , Liu Lihua , Yuan Qing , Li Xiang , Cui Yinghong , Ren Kaiqun , Zou Chang , Chen A. , Xu Chang , Qiu Yebei , Quan Meifang , Zhang Jiansong , Cao Jianguo , Chen Xiangding 
Published: June 2019

AbstractBackgroundManganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating MnSOD and FoxM1 expression.MethodsSecond-generation spheres from the hepatic carcinoma cell lines, respectively, were used as HCSLCs. Protein amounts of MnSOD, FoxM1 and stemness-associated markers (CD133, CD44, ALDH1, Bmi1, Nanog and Oct4) were determined by immunoblotting. In vitro carcinogenicity was evaluated by sphere- and colony-formation assays. The effects of isovitexin on HCSLC carcinogenicity and stemness were examined in vitro and in xenograft models. An adenoviral delivery system was employed to manipulate MnSOD and/or FoxM1. Luciferase reporter assay was performed to verify isovitexin downregulated FoxM1 by inhibiting MnSOD-mediated effects of E2F1 and/or Sp1 on activation of FoxM1 promoter.ResultsFoxM1 upregulation by MnSOD contributed to carcinogenicity and stemness, with increased sphere- and colony-formation capabilities, upregulated stemness-associated markers and CD133+subpopulation as well as elevated oncogenicity in vivo in HCSLCs compared with hepatic carcinoma cells. Isovitexin substantially decreased sphere and colony formation rates, and stemness-associated markers in cultured HCSLCs by suppressing MnSOD and FoxM1 expression. Importantly, isovitexin significantly inhibited tumor growth of in nude mice bearing HCSLCs and reduced CD133 protein expression of xenograft in nude mice. MnSOD or FoxM1 knockdown enhanced the effects of isovitexin suppression on carcinogenicity and stemness in HCSLC. MnSOD or FoxM1 overexpression attenuated the effects of isovitexin. Additionally, isovitexin and MnSOD knockdown could inhibit FoxM1 reporter activity via a decreased binding of E2F1 and/or Sp1 onto FoxM1 promoter. FoxM1 overexpression reversed the effects of isovitexin combined with MnSOD knockdown, without affecting MnSOD expression. Moreover, MnSOD knockdown plus thiostrepton, a FoxM1 specific inhibitor, cooperated with isovitexin to repress xenograft tumor growth and downregulate MnSOD and FoxM1 in nude mice bearing HCSLCs from MHCC97H cells.ConclusionsIsovitexin inhibits carcinogenicity and stemness in HCSLCs by downregulating FoxM1via inhibition of MnSOD.
Identifying the Most Costly Patients in Radiation Oncology and Predicting the Top Spenders
Authors: Waddle Mark R. , Kaleem Tasneem A. , Stross William C. , Malouff Timothy D. , White Launia , Li Zhou , Naessens James , Spaulding Aaron , Aljabri Duaa , Ma Daniel J. , Keole Sameer , Miller Robert C. 
Published: June 2019

PURPOSE: Quality payment programs aim to adjust payments on the basis of quality and cost; however, few quality metrics exist in radiation oncology. This study evaluates and predicts the top spenders (TS) after radiation therapy (RT). MATERIALS AND METHODS: Patient characteristics, cancer details, treatments, toxicity, and survival data were collected for patients treated with RT at Mayo Clinic from 2007 to 2016. Standardized costs were obtained and adjusted for inflation. TSs were identified as those with greater than 93rd percentile costs (≥ $120,812). Prediction models were developed to predict TSs using training and validation sets using information available at consultation, after RT, and at last follow-up. RESULTS: A total of 15,131 patients were included and 1,065 TSs identified. Mean cost overall was $55,290 (median, $39,996) for all patients. Prediction models 1, 2, and 3 had concordance statistics of 0.83 to 0.83, 0.85 to 0.85, and 0.87 to 0.88, respectively in training and validation, indicating excellent prediction of TSs. Factors that were most predictive of TSs included stage N/A and stage 4 ( v stage 0; odds ratio [OR], 18.23 and 8.44, respectively; P < .001); hematologic, upper GI, skin and lung cancers ( v breast; OR, 11.45, 7.69, 3.81, and 2.43, respectively; P < .01); immunotherapy, surgery, and chemotherapy use (OR, 4.36, 2.51, and 1.61, respectively; P < .01); hospitalizations within 90 days of RT (OR, 2.26; P < .01); or death during the episode (OR, 1.56; P < .01). CONCLUSION: This is the first study of its kind to predict with high accuracy the highest spenders in radiation oncology. These patients may benefit from pre-emptive management to mitigate costs, or may require exclusion or adjustment from quality payment programs.
Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh)
Authors: Veerman Christiaan C. , Mengarelli Isabella , Koopman Charlotte D. , Wilders Ronald , van Amersfoorth Shirley C. , Bakker Diane , Wolswinkel Rianne , Hababa Mariam , de Boer Teun P. , Guan Kaomei , Milnes James , Lodder Elisabeth M. , Bakkers Jeroen , Verkerk Arie O. , Bezzina Connie R. 
Published: June 2019

ABSTRACT
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5 variant. Using CRISPR/Cas9-based targeting, we generated an isogenic series of human induced pluripotent stem cell (hiPSC) lines that were either wild type, heterozygous or homozygous for the GNB5 p.S81L variant. These were differentiated into cardiomyocytes (hiPSC-CMs) that robustly expressed the acetylcholine-activated potassium channel [I(KACh); also known as IK,ACh]. Baseline electrophysiological properties of the lines did not differ. Upon application of carbachol (CCh), homozygous p.S81L hiPSC-CMs displayed an increased acetylcholine-activated potassium current (IK,ACh) density and a more pronounced decrease of spontaneous activity as compared to wild-type and heterozygous p.S81L hiPSC-CMs, explaining the bradycardia in homozygous carriers. Application of the specific I(KACh) blocker XEN-R0703 resulted in near-complete reversal of the phenotype. Our results provide mechanistic insights and proof of principle for potential therapy in patients carrying GNB5 mutations.
This article has an associated First Person interview with the first author of the paper.
Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages
Authors: Desgrange Audrey , Lokmer Johanna , Marchiol Carmen , Houyel Lucile , Meilhac Sigolène M. 
Published: June 2019

ABSTRACT
Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart. Advances in understanding the underlying physiopathological mechanisms have been hindered by the lack of a standardised and exhaustive procedure in mouse models for phenotyping left/right asymmetries of all visceral organs. Here, we have developed a multimodality imaging pipeline, which combines non-invasive micro-ultrasound imaging, micro-computed tomography (micro-CT) and high-resolution episcopic microscopy (HREM) to acquire 3D images at multiple stages of development and at multiple scales. On the basis of the position in the uterine horns, we track in a single individual, the progression of organ asymmetry, the situs of all visceral organs in the thoracic or abdominal environment, and the fine anatomical left/right asymmetries of cardiac segments. We provide reference anatomical images and organ reconstructions in the mouse, and discuss differences with humans. This standardised pipeline, which we validated in a mouse model of heterotaxy, offers a fast and easy-to-implement framework. The extensive 3D phenotyping of organ asymmetry in the mouse uses the clinical nomenclature for direct comparison with patient phenotypes. It is compatible with automated and quantitative image analyses, which is essential to compare mutant phenotypes with incomplete penetrance and to gain mechanistic insight into laterality defects.
Navigating the landscape of administrative data in Scotland
Authors: Iveson Matthew H. , Deary Ian J. 
Published: June 2019

Background: There is growing interest in using routinely collected data for research purposes. Following the success of research using routinely collected healthcare data, attention has turned to leveraging administrative data derived from systems providing other services to the population (e.g., education, social security) to conduct research on important social problems. In Scotland, specialised organisations have been set up to support researchers in their pursuit of using and linking administrative data. The landscape of administrative data in Scotland, however, is complex and changeable, and is often difficult for researchers to navigate. Purpose: This paper provides a researcher’s narrative of the steps required to gain the various approvals necessary to access and link administrative data for research in social and cognitive epidemiology. Findings: This paper highlights the problems, particularly regarding the length and complexity of the process, which researchers typically face, and which result in a challenging research environment. The causes of these problems are discussed, as are potential solutions. Conclusions: Whereas the potential of administrative data is great, more work and investment are needed on the part of all those concerned – from researchers to data controllers – in order to realise this potential.
Split and Non-Split Dominator Chromatic Numbers and Related Parameters
Authors: Kavitha K , David N G , Selvi N. 
Published: June 2019

A proper graph coloring is defined as coloring the nodes of a graph with the minimum number of colors without any two adjacent nodes having the same color. Dominator coloring of G is a proper coloring in which every vertex of G dominates every vertex of at least one color class. In this paper, new parameters, namely strong split and non-split dominator chromatic numbers and block, cycle, path non-split dominator chromatic numbers are introduced. These parameters are obtained for different classes of graphs and also interesting results are established.
Biodegradation of Phenolic Pollutants
Authors: Arvind Mahesh 
Published: June 2019

Phenolic compounds are important constituents of petrochemical waste waters arising from transformation processes. Phenol together with substituted halophenols, nitrophenols and alkyl phenols are the main constituents. An Arthrobacter citreus spp. strain MSA - 2005 initially selected for growth at the expense of phenol as the sole source of carbon and energy, was enriched with phenolic compounds such as 4-nitrophenol, 4- chlorophenol and 4-methyl phenol. Metabolization of these compounds upto their maximum levels in the mineral salt medium was studied. The complete metabolization of 4-nitrophenol upto 15mM, 4- chlorophenol up to 12mM and 4-methyl phenol upto 6mM against phenol upto 22mM was achieved in 24 hours. The metabolism of these compounds by the isolated strain occurred through the involvement of catechol derivatives as key intermediates which are further hydrolysed to hydroxy quinol which enters the β -keto adipate pathway. Results indicate that the cells contain mono and di- oxygenase enzymes necessary for these conversions. The degradation rates of these phenolic compounds, by agar immobilized cells has also been reported.
Minimum Breadth of a Graph
Authors: Tabitha Agnes M , Sudershan Reddy L 
Published: June 2019

Breadth of a graph as the maximum of heights taken over all diametral paths is investigated in [3, 4], where height is taken by placing each diametral path on level y = 0 and placing uniquely the rest of the vertices on levels y = 1, 2…k keeping adjacency intact. A parameter minimum breadth is introduced as minimum of heights with respect to all diametral paths. A few results on minimum breadth in certain classes of graphs are presented. Also the bounds on number of vertices and edges for graphs of known diameter and minimum breadth are proposed.
Study of Electron Transfer between Amines and Biologically Active 4 - Aryloxymethylcoumarin
Authors: Raghavendra U P 
Published: June 2019

Electron transfer from aliphatic and aromatic amines to biologically active 4-aryloxymethyl coumarin1-(4- iodophenoxymethyl)-benzo[ f ]coumarin (1IPMBC) has been investigated in acetonitrile solvent. The variation of quenching rate parameter with reduction potential of amines indicates the electron transfer from amines to investigated coumarin molecule.Experimentally determined values of quenching rate parameter k q are well correlated with the standard free energy changes ( ∆G 0 ) within the framework of Marcus electron transfer theory. In the investigatedsystems,solvent reorganization energy appears to play a major role in governing electron transfer dynamics.
Elevando la barra en los estándares de ética y transparencia en las publicaciones científicas
Authors: Gutiérrez-Peláez Miguel , Ramírez Luisa 
Published: June 2019

Recientemente, la Universidad del Rosario estableció su membresía con el Committee on Publication Ethics (COPE) [Comité de Ética en las Publicaciones], y sí se ha convertido la primera universidad en Colombia que adopta, para sus distintaspublicaciones y revistas, los exigentes estándares del Código de Conducta y Guía para las Mejores Prácticas Editoriales y, de esta manera, se compromete a trabajar por las buenas prácticas en publicación. COPE brinda asesoría y directrices a editores y editoriales sobre el manejo de aspectos puntuales y cruciales relativos a la ética en las publicaciones científicas (http://publicationethics.org/).
Susceptibility-weighted MR imaging (SWI) of basal ganglia iron deposition in the early and advanced stages of Parkinson's disease
Authors: Trufanov A. G. , Yurin A. A. , Buriak A. B. , Sandalov S. A. , Odinak M. M. , Litvinenko I. V. 
Published: June 2019

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and the first one among the nosological entities of parkinsonism. Susceptibility-weighted imaging (SWI), magnetic resonance imaging (MRI) pulse sequence, which allows the in vivo estimation of the values of iron deposition in different areas of the brain, is a potential technique for the early diagnosis of PD and for the study of the pathogenesis of its complications.Objective: to compare the values of iron deposition in the basal ganglia in Stages II and III PD and to determine the relationship of clinical findings to the level of iron deposition according to the SWI findings.Patients and methods. Twenty-four patients with Hoehn and Yahr Stages II (n=24) and III (n=12) PD were examined. All the patients underwent brain MRI on a Siemens TrioTim (3T) MRI scanner by using pulse sequences T1, T2, SWI and subsequently quantifying the iron deposition (SPIN software). The accumulation of iron is visualized as an area of reduced signal intensity on SWI, and its estimation in accordance with the SPIN program has accordingly a smaller value. The regions of interest on both sides were the dentate nucleus, substantia nigra, red nucleus, putamen, globus pallidus, and head of the caudate nucleus. The examination protocol also included tests using the following scales: the Unified Parkinson's Disease Rating Scale (UPDRS), the Mini-Mental State Examination (MMSE), Frontal Assessment Batter (FAB), Freezing of Gait (FOG), Gait and Balance Scale (GABS), the Epworth Daytime Sleepiness Scale, the Parkinson's Disease Quality of Life Questionnaire (PDQ), the Beck Depression Inventory, and the Clock-Drawing Test.Results and discussion. The investigators found significant (p<0.05) correlations between the clinical picture and the level of iron deposition in the regions of interest in patients with Stage II PD: FOG – left caudate nucleus (r=-0.94); GABS – left caudate nucleus (r=-0.94); and in patients with stage III of the disease: UPDRS (full) – left red nucleus (r=-0.82), right globus pallidus (r=-0,80), left putamen (r=-0,96); UPDRS (Section 2) – left red nucleus (r=-0.77), left globus pallidus (r=-0.84); UPDRS (Section 3) – right putamen (r=-0,85), right globus pallidus (r=-0.78), left globus pallidus (r=-0,92); FOG – left globus pallidus (r=-0.81); GABS – left red nucleus (r=-0.96), left putamen (r=0.82), right putamen (r=-0.89), left globus pallidus (r=-0.82), right globus pallidus (r=-0.85), left caudate nucleus (r=-0.82), right caudate nucleus (r=-0.89); Beck Depression Inventory – right substantia nigra (r=-0.82).Conclusion. SWI measurement of the values of iron deposition in the structures of the extrapyramidal system in PD provides an additional insight into the pathological processes occurring in them.
Ethnic characteristics of location for cerebral aneurysms
Authors: Chugunova S. A. 
Published: June 2019

Objective: to establish the characteristics of location for cerebral aneurysms according to ethnicity in the population of Yakutia.Patients and methods. A total of 433 patients with aneurysmal hemorrhagic stroke (AHS) who had been admitted consecutively to the regional vascular center (Yakutsk) were examined. Group 1 included representatives of the indigenous ethnic groups of the Asian race in Yakutia (n=331; 33.8% of men); Group 2 comprised patients of the Caucasian race (n=102; 45.1% of men). The diagnosis was made by digital subtraction cerebral angiography (77.6%) and multislice computed tomography angiography (22.4%).Results. A total of 433 ruptured saccular aneurysms, including the latter in the anterior cerebral and anterior communicating arteries (ACAAcoA) (33.8%), middle cerebral artery (MCA) (38.7%), internal carotid artery (ICA) (21.6%), and vertebrobasilar arteries (5.8%), were diagnosed. In Group 1, the most common location for aneurysms was MCA (41.1 and 39.7% in men and women, respectively); in Group 2, that was ACA-AcoA (52.2%) in men and ICA (42.8%) in women. The ethnic groups showed significant differences in the incidence of MCA aneurysms (40.2 and 26.4% in Groups 1 and 2; respectively (p=0.014)); (odds ratio (OR = 1.866; 95% confidence interval (CI), 1.111–3.146). In Group 1, the incidence of MCA aneurysms was higher in women than in those in Group 2 (p=0.012) (OR=2.417; 95% CI, 1.155–5.141).Conclusion. The location for cerebral aneurysms differs according to ethnicity. In Yakutia among AHS patients, the most frequent location for aneurysms is MCA among indigenous Asians, while that is ACA-AcoA in Caucasian men and ICA is in Caucasian women. The incidence of MCA aneurysms is significantly higher in indigenous Asian women than in Caucasian ones.
Differentiated approach and indications for optimization of agomelatine therapy for endogenous depression
Authors: Abramova L. I. , Panteleeva G. P. , Nikiforova I. Yu. , Novozhenova T. E. 
Published: June 2019

Objective: to develop and justify differentiated indications for the use of agomelatine (valdoxan) to treat the typological variants of endogenous depressions with varying severity on the basis of an analysis of its therapeutic efficacy.Patients and methods. An open prospective study was conducted using the clinical, psychopathological, and psychometric rating scales: the Hamilton Depression Rating Scale (HAMD-21); Udvalg for Kliniske Undersњgelser Scale (UKU); the Snaith-Hamilton Pleasure Scale (SHAPS) for assessing anhedonic disorders, and statistical methods. Examinations were made in 56 patients (mean age, 34.9 years) with moderate and severe endogenous depression within affective psychosis (n=42) and shift-like schizophrenia (n=14) (ICD-10 items F31.3–4; F32.1–2, and F33.1–2). The patients received a cycle treatment with agomelatine (valdoxan) 25–50 mg once a day in the evening for 4–8 weeks. The patients' status was evaluated over time on fixed days from a reduction in the mean total score (MTS) of the respective scales as insignificant (less than 19% reduction in disorders), moderate (20–49%), good (50–69%), and excellent (70% or more) effects. The effect of agomelatine was analyzed in two patient groups. The specific features of the antidepressive effect and its dynamics in the presence of endogenous depressions of different typologies (melancholic, anxious, and adynamic depressions) were studied in Group 1 (n=26); the effect of agomelatine on anhedonic endogenous depressions and manifestations of anhedonia in different mental activity areas (interests, social activity, emotional engagement and eating/drinking) was investigated in Group 2 (n=30).Results and discussion. There was a good tolerance and a high antidepressant activity of agomelatine during its treatment cycle for moderate and severe endogenous depressions. A significant improvement (an 84.4% reduction in HAMD-21 MTS) was noted in patients at 3 and 4 weeks of the treatment cycle and consistently persisted at a subsequent follow-up. Agomelatine showed a good effect (a 50% or more reduction in HAMD-21 MTS) just at 14 days of therapy. The drug was observed to have a balanced antidepressant effect, significant thymoleptic, stimulant, anxiolytic, and antianhedonic activities (reductions in the MTS of depressive disorders by 90.83, 84.9, 82.39, and 78.9%, respectively).Conclusion. The universal spectrum of the antidepressive effect of agomelatine, its good tolerability, high efficacy, and rapid improvement makes it the drug of choice in treating a wide range of psychopathological endogenous depressions: melancholic, apatho-adynamic, anxious, and anhedonic ones.