bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of C-section diverticula with hysteroscopic resection in women without childbearing intention: a retrospective cohort study
Authors: Shi Hui , He Jingyan , Gao Yunhe , Qin Shuang , Fan Jiaying , Xiao Qing , Li Kuanrong , Liang Huiying 
Published: September 2019

Abstract
Background: Diverticulum, one of the long-term squelae of cesarean section, can cause abnormal uterine bleeding, dysmenorrhea and chronic pelvic pain. Hysteroscopic resection of diverticula is thought to reduce abnormal uterine bleeding and chronic pelvic pain. In this study, we aim to describe the improvement after hysteroscopic resection of cesarean section diverticula hysteroscopic resection of cesarean section diverticula (CSD) in women without childbearing intention, and to explore the variables associated with poor prognosis.Methods: A retrospective cohort study of women aged 25-48 with CSD diagnosis by transvaginal ultrasonography (TVS) and hysteroscopy that were enrolled at Guangzhou Women and Children’s Medical Center between June 2017 and December 2018. A total of 124 women met the inclusion criteria and all patients had undergone hysteroscopic resection and accepted a follow-up interview at the 3rd and 6th months postoperatively to record symptom improvement.Result: The mean of intraoperative blood loss and operative time of hysteroscopic resection were (12.94±12.63) ml and (33.63±6.87) min in 124 patients. Overall observed improvement rates of CSD symptom were 47.2% and 65.6% in the first 3 and 6 months, respectively. Multivariable logistic regression models revealed that timing of surgery <14 days was a good prognostic factor associated with both 3-month improvement (OR, 16.59; 95% CI, 2.62-104.90; P=0.003) and 6-month improvement (OR, 15.51; 95%CI, 1.63-148.00; P=0.02); Patients with numbers of cesarean section(CS) ≥2 had a lower rate of improvement after 6 months of CSD repair surgery compared with patients who underwent one CS(OR, 8.29; 95%CI, 1.05-65.75; P=0.04).Conclusions: A hysteroscopic repair might be an appropriate method for CSD in women who no childbearing intentions. The timing of surgery and the number of CS seems to be factors influencing the postoperative improvement of CSD.
Role of Sex Hormones And Their Receptors On Gastric Nrf2 And Neuronal Nitric Oxide Synthase Function In An Experimental Hyperglycemia Model
Authors: Sprouse Jeremy , Sampath Chethan , GANGULA PANDU 
Published: September 2019

Abstract
Background: Gastroparesis, a condition of abnormal gastric emptying, is most commonly observed in diabetic women. To date, the role of ovarian hormones and/or gastric hormone receptors on regulating nitrergic-mediated gastric motility remains inconclusive. Aim: The purpose of this study is to investigate whether sex hormones/their receptors can attenuate altered Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), neuronal Nitric Oxide Synthase (nNOS) expression and nitrergic relaxation in gastric neuromuscular tissues exposed to in-vitro hyperglycemia (HG). Methods: Gastric neuromuscular sections from adult female C57BL/6J mice were incubated in normoglycemic (NG, 5mM) or hyperglycemic (30 mM or 50 mM) conditions in the presence or absence of selective estrogen receptor (ER) agonists (ERα /PPT or ERβ: DPN); or non-selective sex hormone receptor antagonists (ER/ICI 182,780, or progesterone receptor (PR)/ RU486) for 48 hours. mRNA, protein expression and nitrergic relaxation of circular gastric neuromuscular strips were assessed. Results: Our findings in HG, compared to NG, demonstrate a significant reduction in ER, Nrf2, and nNOS expression in gastric specimens. In addition, in-vitro treatment with sex hormones and/or their agonists significantly (*p<0.05) restored Nrf2/nNOSα expression and total nitrite production. Conversely, ER, but not PR, antagonist significantly reduced Nrf2/nNOSα expression and nitrergic relaxation. Conclusions: Our data suggest that ER’s can regulate nitrergic function by improving Nrf2/nNOS expression in experimental hyperglycemia. Keywords: Gastroparesis; Sex Hormones; Estrogen Receptors; Drug Therapy; nNOS, Nrf2, Nitrergic Relaxation
CUTANEOUS LEISHMANIASIS A NEGLECTED TROPICAL DISEASE: COMMUNITY KNOWLEDGE, ATTITUDE AND PRACTICES IN AN ENDEMIC AREA, NORTHWEST ETHIOPIA
Authors: Tamiru Helina Fikre , Mashalla Yohana James , Mohammed Rezika , Tshweneagae Gloria Thupayagale 
Published: September 2019

Abstract
Background
Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, attitude and practice of the community in endemic areas are scanty. The study aimed to assess the knowledge, attitude towards cutaneous leishmaniasis and treatment seeking practices in people living in the endemic highlands areas in the Northwest, Ethiopia and provide evidence-based information to guide development of appropriate interventions to reduce the impact of cutaneous leishmaniasis on communities.
Methods
Quantitative cross-sectional study was conducted in cutaneous leishmaniasis endemic districts (woredas) using a semi structured questionnaires. Households were randomly selected according to probability proportional to size of households in each enumeration area. Systematic random sampling of eligible households was based on the number of households recorded during listing of households. Descriptive statistics was used to describe numerical data, organise and summarise the data in a manner that gave meaning to the numerical form. Frequency tables were used to show descriptive analysis and regression analysis was used to determine correlation between variables.
Results
Majority of respondents 321(78.7%) lived in rural areas, age ranged between 18 and 85 years and most were farmers. Illiteracy was high (47.6%) among respondents and majority 358(87.8%) had seen patients with CL. Less than quarter (21.6%) had heard about sand flies and knowledge on the peak transmission period was low (46.3%). About 192 (47.1%) of the respondents indicated disfiguring lesions were the major clinical presentations, less than half 55(27.5%) of urban residents believed CL was treatable compared to 145(72.5%) of rural residents (P < 0.001). Traditional medicines were indicated as best treatment option by 209(51.2%) compared to 114(27.9%) for modern treatment. Major factors influencing treatment options included accessibility to treatment facilities, distance and short duration of treatment. Participants expressed negative experiential attitude and perceived control towards modern treatment because of inaccessibility and distance from where modern treatment is provided.
Conclusion
Priority should be given to primary prevention and appropriate awareness campaigns on lesion recognition, prevention. Information on modern treatment should be intensified.
Heat Transfer Analysis of Shell and Tube Heat Exchanger Cooled Using Nanofluids
Authors: Kareemullah Mohammed , Chethan K.M. , Fouzan Mohammed K. , Darshan B.V. , Kaladgi Abdul Razak , Prashanth Maruthi B.H. , Muneer Rayid , Yashawantha K.M. 
Published: September 2019

Background::
In Shell and Tube Heat Exchanger (STHX), heat is exchanged between hot
water (coming from industrial outlet by forced convection) to the cold water. Instead of water, if Nano
fluids are used into these tubes, then there is a possibility of improved heat transfer because of high
thermal conductivity of the nanofluids.

Objective::
From many literature and patents, it was clear that the study of STHX using metal oxide
nanoparticles is very scarce. Therefore, the objective of the present investigation is to check the thermal
performance of STHX operated with zinc oxide nanofluid and compare with water as the base fluid.

Methods::
Heat transfer analysis of a shell and tube heat exchanger was carried out experimentally using
Zinc oxide as a nanofluid. Mass flow rate on tube side was varied while on the shell side it was kept
constant. Various heat transfer parameters like heat transfer coefficient, heat transfer rate effectiveness
and LMTD (Log Mean Temperature Difference) were studied. The experimental readings were recorded
after the steady-state is reached under forced flow conditions.

Results::
It was found that the effectiveness improves with increase in mass flow rate of nanofluids as
compared to base fluid.

Conclusion::
From the obtained results, it was concluded that heat transfer enhancement and effectiveness
improvement does occur with nano fluids but at the cost of pumping power.
Hubungan Shear Wave Elastography Ginjal dengan Estimated Glomerular Filtration Rate pada Pasien Penyakit Ginjal Kronik
Authors: Arif Asnita , Idris Nurlaily , Murtala Bachtiar , Zainuddin Andi Alfian , Asriyani Sri , Kasim Hasyim 
Published: September 2019

Penyakit ginjal kronik (PGK) merupakan masalah kesehatan global dengan biaya ekonomi tinggi pada sistem kesehatan sehingga dibutuhkan modalitas pencitraan klinis non invasif untuk mendeteksi penyakit ginjal pada stadium awal. Shear wave elastography (SWE) merupakan pemeriksaan imaging untuk menilai tingkat keparahan dari perubahan morfologi kronik ginjal berdasarkan pengukuran elastisitas kortex. Penelitian ini bertujuan mengetahui hubungan antara SWE dengan estimated glomerular filtration rate (eGFR) sehingga SWE dapat direkomendasikan untuk deteksi dini tingkat keparahan penyakit ginjal kronik.Â Penelitian ini dilakukan di bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dari bulan September 2018 sampai dengan Februari 2019. Desain penelitian yang digunakan adalah observasional dengan rancangan potong lintang. Sampel penelitian sebanyak 118 sampel yang terdiri dari 71 sampel dengan penyakit ginjal kronik dan 47 sampel normal. Pemeriksaan ultrasonografi yang dilakukan dengan metode SWE untuk mengukur shear wave velocity (SWV) pada kedua ginjal dengan tiga kali pengukuran pada kortex ginjal. Nilai median dari SWV pada kedua ginjal dihubungkan dengan eGFR. Data dianalisis dengan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa nilai median SWV pada kelompok sampel normal adalah 2,02Â±0,32m/s pada ginjal kananÂ 2,01Â±0,32m/s pada ginjal kiri yang cenderung menurun dengan bertambahnyaÂ usia. Terdapat korelasi positif yang signifikan antara nilai SWV pada ginjal kanan dan kiri dengan eGFR, dengan arah korelasi positif (p<0,0001). Pada penelitian ini, terdapat pula korelasi negatif yang signifikan antara tekanan darah dan proteinuria dengan eGFR maupun dengan SWV pada pasien penyakit ginjal kronik.
Improving Pacific Adolescents’ Physical Activity Toward International Recommendations: Exploratory Study of a Digital Education App Coupled With Activity Trackers
Authors: Galy Olivier , Yacef Kalina , Caillaud Corinne 
Published: September 2019

Background
The prevalence of overweight and obesity in children and adolescents has dramatically increased in the Pacific Island countries and territories over the last decade. Childhood overweight and obesity not only have short-term consequences but are also likely to lead to noncommunicable diseases in adulthood. A major factor contributing to the rising prevalence is an insufficient amount of daily moderate-to-vigorous physical activity (MVPA). In the Pacific region, less than 50% of children and adolescents meet the international recommendations of 11,000 steps and 60 min of MVPA per day. Although studies have shown the potential of digital technologies to change behaviors, none has been proposed to guide adolescents toward achieving these recommendations.

Objective
The aims of this study were (1) to investigate whether a technology-based educational program that combines education, objective measures of physical activity (PA), and self-assessment of goal achievement would be well received by Pacific adolescents and help change their PA behaviors toward the international PA recommendations and (2) to create more insightful data analysis methods to better understand PA behavior change.

Methods
A total of 24 adolescents, aged 12 to 14 years, participated in a 4-week program comprising 8 1-hour modules designed to develop health literacy and physical skills. This self-paced user-centered program was delivered via an app and provided health-related learning content as well as goal setting and self-assessment tasks. PA performed during the 4-week program was captured by an activity tracker to support learning and help the adolescents self-assess their achievements against personal goals. The data were analyzed using a consistency rate and daily behavior clustering to reveal any PA changes, particularly regarding adherence to international recommendations.

Results
The consistency rate of daily steps revealed that the adolescents reached 11,000 steps per day 48% (approximately 3.4 days per week) of the time in the first week of the program, and this peaked at 59% (approximately 4.1 days per week) toward the end of the program. PA data showed an overall increase during the program, particularly in the less active adolescents, who increased their daily steps by 15% and ultimately reached 11,000 steps more frequently. The consistency of daily behavior clustering showed a 27% increase in adherence to international recommendations in the least active adolescents.

Conclusions
Technology-supported educational programs that include self-monitored PA via activity trackers can be successfully delivered to adolescents in schools in remote Pacific areas. New data mining techniques enable innovative analyses of PA engagement based on the international recommendations.
Searching the Internet for Infertility Information: A Survey of Patient Needs and Preferences
Authors: Brochu Felicia , Robins Stephanie , Miner Skye A , Grunberg Paul H , Chan Peter , Lo Kirk , Holzer Hananel E G , Mahutte Neal , Ouhilal Sophia , Tulandi Togas , Zelkowitz Phyllis 
Published: September 2019

Background
Given the complexity of infertility diagnoses and treatments and the convenience of the internet for finding health-related information, people undergoing infertility treatments often use Web-based resources to obtain infertility information and support. However, little is known about the types of information and support resources infertility patients search for on the internet and whether these resources meet their needs.

Objective
The aims of this study were to (1) examine what individual factors, namely, demographic characteristics and distress, are associated with searching the internet for different types of infertility-related information and support resources and (2) determine whether Web-based resources meet the needs of patients.

Methods
Men and women seeking infertility care responded to a survey assessing use of Web-based resources for accessing infertility-related information and support. The survey further assessed satisfaction with Web-based resources as well as perceived stress and depressive symptomatology.

Results
A total of 567 participants, including 254 men and 313 women, completed the survey. Most participants (490/558, 87.8%) had searched the internet for infertility information and support. Searchers were more likely to be women (P<.001), highly educated (P=.04), long-term patients (P=.03), and more distressed (P=.04). Causes of infertility, treatment options, and scientific literature about infertility were the three most frequently searched topics, whereas ways to discuss treatment with family and friends as well as surrogacy and ways to find peer support were the three least searched topics. Of those who searched the internet, 70.9% (346/488) indicated that their needs were met by Web-based information, whereas 29.1% (142/488) said that their needs were not met. Having unmet needs was related to greater levels of perceived stress (P=.005) and depressive symptomatology (P=.03).

Conclusions
This study provides evidence for the important role of the internet in accessing infertility information and support and for the ability of Web-based resources to meet patients’ needs. However, although distressed patients reported particularly high rates of searching, their needs were not always met, suggesting that they may benefit from alternative sources of information and support or guidance from health care providers when searching the internet.
Sero-prevalence of bovine Leukemia virus in cattle from Caquetá state, Colombia
Authors: Motta-Delgado Pablo Andrés , Rivera-Calderón Luis Gabriel , Herrera-Valencia Wilmer , Martínez-Tovar Ricardo Alberto , Londoño-Sánchez Marliyanini , Rojas-Vargas Erika Paola , Muñoz-Murcia Angie Liseth , Gutiérrez-Quintero María Elodia 
Published: September 2019

Bovine Leukemia Virus (BLV) is the agent of enzootic bovine leukosis (EBL), this disease is a neoplasm of lymphatic tissue in bovine species. The aim of this article was determinate the prevalence of bovine leukemia virus in dual-purpose cattle from nine municipalities that produce the 98% of milk in the Caquetá state, Colombia. Blood samples were collected in 100 herds dedicates to dual purpose cattle, obtained blood serum from 1000 animals, of which 893 corresponding to cows. Indirect Elisa test for detection of antibodies anti-GP51 of BLV was performance and the positive cases were considered if the serum-to-positive ratio with percentages of M/N lower than 40%. Categorized data were analyzed by contingency tables and ANOVA at the significant level of p<0.05 by DGC test was performed. The overall sero-prevalence of BLV in Caquetá state was of 25.18% (95%, CI: 21.9-28.46%), in males 26.25% and females 25.37% respectively. At municipal level the sero-prevalence varied of 7.12 to 41.81%. The prevalence of BLV at herd level was of 67% (95%, CI: 57.24-76.76%). In conclusion, the sero-prevalence of BLV in the dual-purpose livestock system over 36 months of age in Caquetá state is moderate, do not exist statistical difference between sero-prevalence of cows and bulls. At level of herds the prevalence of BLV is high. Improving strategies of control and managements in the herds, as well as implement policies of sanitary management are necessary.
Sediaan Farmasi yang Mengandung Mineral untuk Veterinary Sapi
Authors: Megawati Ega , Wathoni Nasrul 
Published: September 2019

Mineral merupakan salah satu faktor yang dapat mempengaruhi kualitas dari hewan ternak dimana 3-5% dari tubuh hewan ternak pada umumnya terdiri dari zat-zat mineral. Beberapa penyakit pada hewan ternak telah diketahui dipicu oleh adanya defisiensi mineral. Dalam Artikel ini akan dibahas apa saja gangguan atau penyakit yang mungkin terjadi akibat defesiensi penyakit pada hewan ternak Sapi dan bagaimana fungsi mineral itu sendiri, serta tinjauan mengenai sediaan-sediaan Farmasi. Hasil yang didapatkan adalah mineral akan mempengaruhi fungsiologi dari tubuh sapi sehingga mengakibatkan beberapa gangguan dan ditinjau dari 5 sediaan Farmasi yang telah ditemukan secara efektif dapat meningkatkan status mineral dengan bentuk sediaan oral maupun injeksi.Kata kunci: Sapi, Mineral, Defisensi
Diagnosa Komunikas Brand Activation Dan Media Digital Atas Eksistensi Brand Studio Rekaman Lokananta
Authors: Sukendro Gregorius Genep , Pandrianto Nigar 
Published: September 2019

The use of digital-based communication media and brand activation by the industry can attract the attention of potential consumers or customers. Even from these two activities, consumer trust and loyalty to the brand can be achieved. This research will look at how digital-based brand activation and communication can successfully attract consumers' attention. Therefore a number of marketing communication and marketing theories will be used in this study to dissect and photograph the research object. To analyze data, this research will use SOSTAC analysis. In addition to conducting observations and literature studies, researchers also conducted interviews with industry parties. Therefore this research is expected to be a reference in industrial development by utilizing digital-based communication and brand activation. The results of the study showed Lokananta still had to maximize the use of digital media as a form of brand activation to maintain brand existence. Pemanfaatan media komunikasi berbasis digital dan brand activation oleh industri dapat menarik perhatian calon konsumen atau pelanggan. Bahkan dari kedua kegiatan ini kepercayaan dan loyalitas konsumen kepada brand dapat dicapai. Penelitian ini akan melihat bagaimana brand activation dan komunikasi berbasis digital berhasil dapat menarik perhatian konsumen. Oleh karena itu sejumlah teori komunikasi pemasaran dan pemasaran akan digunakan dalam penelitian ini untuk membedah dan memotret obyek penelitian. Untuk menganalisa data, penelitian ini akan akan menggunakan analisis SOSTAC. Selain melakukan observasi dan studi pustaka, peneliti juga melakukan wawancara dengan pihak industri. Oleh karenanya penelitian ini diharapkan bisa menjadi acuan dalam pengembangan industri dengan memanfaatkan komunikasi berbasis digital dan brand activation. Hasil dari penelitian menunjukkan Lokananta masih harus memaksimalkan penggunaan media digital sebagai bentuk brand activation untuk mempertahankan eksistensi brand.
Impacts of the CPTPP on the Improvement of Vietnam’s Intellectual Property Law
Authors: Que Anh Nguyen Thi , Thao Nguyen Bich 
Published: September 2019

The Intellectual Property Chapter in the Comprehensive and Progressive Agreement for Trans-Pacific Partnership imposes many new obligations on Vietnam, which requires an overhaul of Vietnam’s intellectual property law in order to implement the IP provisions in this Agreement. This article anaylyzes the IP provisions in CPTPP, compares with the current Vietnamese law and with the newly amended Law on Intellectual Property, which was adopted by the National Assembly on June 14, 2019, then identifies which provisions have met the requirements of CPTPP and which provisions need further amendment and supplement.
Keywords: CPTPP, intellectual property, Law on Intellectual Property.
References:
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