bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of B2B seller’s value appropriation upon customer relationship performance
Authors: Zhang Jing , Du Mingfei 
Published: April 2018

PurposeValue appropriation and value creation are two sides of the same coin. How B2B seller’s value appropriation impacts customer relationship performance still remains an under-researched topic. This paper aims to probe into this question in the context of Chinese B2B markets.Design/methodology/approachThis study identifies two kinds of value appropriation, namely, competitive and non-competitive and then examines their impacts upon customer relationship performance, as well as the moderating roles of distributive fairness and procedural fairness, based on questionnaire survey among 273 Chinese B2B firms.FindingsThe authors find that seller’s competitive value appropriation has negative impact upon customer relationship performance, and this link is positively moderated by customer-perceived distributive fairness. Besides, non-competitive value appropriation by the seller has significant and positive impact upon customer relationship performance, and this link is positively moderated by customer-perceived procedural fairness.Originality/valueThe paper contributes greatly to literature of value management and industrial buyer–seller relationship. Managerial implications are provided for B2B companies operating in Chinese market to tackle with the tradeoff between appropriating sufficient value and retaining harmonious relationship with customers.
The role of negative network externalities in SNS fatigue
Authors: Zhu Yun , Bao Zheshi 
Published: April 2018

PurposeThe purpose of this paper is to explore whether negative network externalities would contribute to social networking site (SNS) fatigue and how this mechanism works.Design/methodology/approachA research model was proposed integrating two dimensions of negative network externalities and three dimensions of mediators (impression management concern, privacy concern, and social overload) to indicate how negative network externalities affect users’ SNS fatigue. Online questionnaires were adopted to collect data, and 307 valid samples were analyzed by structural equation modeling approach.FindingsThe findings indicate that negative network externalities have significant indirect effects on SNS fatigue through impression management concern, privacy concern, and social overload, and among the three dimensions, privacy concern plays a more important role.Research limitations/implicationsThis study offers a solidly grounded and well-demonstrated conceptual model that not only indicates the effects of negative network externalities in the context of SNS but also facilitates the understanding of SNS fatigue. Some theoretical and practical implications are also provided.Originality/valueThis study is novel in exploring users’ SNS fatigue a perspective of negative network externalities. Besides, the mediating roles of impression management concern, privacy concern, and social overload have been employed to indicate the formation of SNS fatigue.
Gender, race/ethnicity, and entrepreneurship: women entrepreneurs in a US south city
Authors: Wang Qingfang 
Published: April 2018

PurposeThe purpose of this paper is to examine how gender, interacting with race and ethnicity, plays a role in women entrepreneurship process and how women entrepreneurs’ experiences shape and are shaped by their communities.Design/methodology/approachFirst, five-year 2010-2014 American Community Survey data are analyzed. Then, in-depth interview and focus groups discussion are conducted with 40 women business owners and the data are analyzed using the software package QSR Nvivo.FindingsWomen entrepreneurs face the challenges and the difficulties of managing both family roles and work. However, they have strategically negotiating with their multiple roles through entrepreneurship to gain independence and purpose, as well as the opportunity to contribute to society. In particular, their embeddedness within local communities provides meanings, opportunities, and functional strategies for their entrepreneurial activities.Research limitations/implicationsThe study is based on only one study area. A larger sample size with more cases from multiple study areas can provide further insights.Practical implicationsFindings from this study have profound implications for practices of equitable growth, community development, and urban planning under the rapid growth of immigration.Originality/valueFirst, extending focus on the social identity of “motherhood,” this study argues for considering multiple social identities of women entrepreneurs and the intersectionality of multiple identities. Second, it extends the traditional focus of entrepreneurship studies from a singular focus on economic growth to include additional dimensions of work-life balance and sense of community. Third, place is not only a context but also acts powerfully into the entrepreneurial process. It argues that women entrepreneurs and their businesses are deeply embedded in local communities as their multiple identities are shaped at both home and work.
Innovation and metamorphosis towards strategic resilience
Authors: Morais-Storz Marta , Stoud Platou Rikke , Berild Norheim Kine 
Published: April 2018

PurposeThe purpose of this paper is to examine what it means to be resilient in the context of environmental turbulence, complexity, and uncertainty, and to suggest how organizations might develop strategic resilience.Design/methodology/approachSampling from the theoretical and empirical contributions to the understanding of resilience within the management and organizational literatures, this conceptual paper presents a model of strategic resilience and theoretical propositions are developed that suggest directions for future research.FindingsIt is proposed that strategic resilience is an emergent and dynamic characteristic of organizations whereby organizational legacy is a defining antecedent, top management team future orientation is a fundamental belief system, and problem formulation is a key deliberate process.Research limitations/implicationsAlthough the conceptual inquiry of strategic resilience offers clarity on a complex phenomenon, empirical evidence is needed to provide a test of the concepts and their relations.Practical implicationsBy asserting that the environment is turbulent, complex, and uncertain, this paper opens up new possibilities for the understanding and study of strategic resilience, whereby metamorphosis and innovation are requisites, and entrepreneurship is part and parcel of strategy. As such it highlights the importance of managerial beliefs and behaviors that facilitate proactively and deliberately challenging of the status quo.Originality/valueThe proposed conceptualization of strategic resilience in this paper connotes action rather than just reaction, and in so doing highlights the importance of the synergy between strategic management and entrepreneurship. As such, it proposes factors that may help organizations persist and create value within a context and future that they themselves also shape.
True exogenous shock or just a scapegoat
Authors: Schweizer Lars , Nienhaus Andreas 
Published: April 2018

PurposeSensemaking models generally lack an objective determinant to distinguish between CEO fault and changes in systematic risk caused by exogenous negative shocks like a banking crisis. The interdisciplinary approach of this paper combines attribution theory with econometric time series analyses to provide an objective measure of exogeneity and persistence of a negative shock to an organization. The purpose of this paper is to address the exploratory research question, of how scapegoating by managers can be avoided by the use of an objective and empirical measurement and if the recent financial crisis can be seen as an exogenous shock to manufacturing firms.Design/methodology/approachBy testing for stationarity with a structural break with an econometric time series analysis, the model helps to reduce agency costs during organizational crisis by effectively determining crisis causation and avoid scapegoating by managers.FindingsBy combining the sensemaking models of Haleblian and Rajagopalan (2006), Staw (1980), and Weick (1988), an integrated model of sensemaking in performance crises under the specific context of simultaneously occurring external crises is provided. By applying the authors approach the results suggest that the financial crisis of 2008/2009 has true exogenous adverse effects on US manufacturing firms.Originality/valueThe interdisciplinary approach encourages the integration of econometric time series analysis as an objective determinant in sense making models.
The key gluconeogenic gene PCK1 is crucial for virulence of Botrytis cinerea via initiating its conidial germination and host penetration
Authors: Liu Jian‐Kang , Chang Hao‐Wu , Liu Yue , Qin Yu (Haity) , Ding Yu‐Han , Wang Lan , Zhao Yue , Zhang Ming‐Zhe , Cao Sheng‐Nan , Li Le‐Tao , Liu Wei , Li Gui‐Hua , Qin Qing‐Ming 
Published: April 2018

SummaryThe process of initiation of host invasion and survival of some foliar phytopathogenic fungi in the absence of external nutrients on host leaf surfaces remains obscure. Here, we demonstrate that gluconeogenesis plays an important role in the process and nutrient‐starvation adaptation before the pathogen host invasion. Deletion of phosphoenolpyruvate carboxykinase gene BcPCK1 in gluconeogenesis in Botrytis cinerea, the causative agent of grey mould, resulted in the failure of the ΔBcpck1 mutant conidia to germinate on hard and hydrophobic surface and penetrate host cells in the absence of glucose, reduction in conidiation and slow conidium germination in a nutrient‐rich medium. The wild‐type and ΔBcpck1 conidia germinate similarly in the presence of glucose (higher concentration) as the sole carbon source. Conidial glucose‐content should reach a threshold level to initiate germination and host penetration. Infection structure formation by the mutants displayed a glucose‐dependent fashion, which corresponded to the mutant virulence reduction. Exogenous glucose or complementation of BcPCK1 completely rescued all the developmental and virulence defects of the mutants. Our findings demonstrate that BcPCK1 plays a crucial role in B. cinerea pathogenic growth and virulence, and provide new insights into gluconeogenesis mediating pathogenesis of plant fungal pathogens via initiation of conidial germination and host penetration.
Unravelling a new catabolic pathway of C‐19 steroids in Mycobacterium smegmatis
Authors: Fernández‐Cabezón Lorena , Galán Beatriz , García José L. 
Published: April 2018

SummaryIn this work, we have characterized the C‐19+ gene cluster (MSMEG_2851 to MSMEG_2901) of Mycobacterium smegmatis. By in silico analysis, we have identified the genes encoding enzymes involved in the modification of the A/B steroid rings during the catabolism of C‐19 steroids in certain M. smegmatis mutants mapped in the PadR‐like regulator (MSMEG_2868), that constitutively express the C‐19+ gene cluster. By using gene complementation assays, resting‐cell biotransformations and deletion mutants, we have characterized the most critical genes of the cluster, that is, kstD2, kstD3, kshA2, kshB2, hsaA2, hsaC2 and hsaD2. These results have allowed us to propose a new catabolic route named C‐19+ pathway for the mineralization of C‐19 steroids in M. smegmatis. Our data suggest that the deletion of the C‐19+ gene cluster may be useful to engineer more robust and efficient M. smegmatis strains to produce C‐19 steroids from sterols. Moreover, the new KshA2, KshB2, KstD2 and KstD3 isoenzymes may be useful to design new microbial cell factories for the 9α‐hydroxylation and/or Δ1‐dehydrogenation of 3‐ketosteroids.
The economic impacts of using adalimumab (Humira®) for reducing pain in people with ankylosing spondylitis: A microsimulation study for Australia
Authors: Schofield Deborah , Shrestha Rupendra , Cunich Michelle 
Published: April 2018

AbstractAimThe onset and progression of ankylosing spondylitis (AS) usually occurs during the life stage when individuals are more likely to be working and receiving an income, but little is known about the effects of interventions that reduce pain and improve the economic circumstances of patients out of the labour force due to AS. This study evaluates the economic benefits of pain reduction among people aged 19–64 with AS using adalimumab (Humira®) from the patient and governmental perspectives.MethodsWe estimated the benefits of adalimumab for reducing pain in people aged 19–64 with AS in terms of labor force participation and earnings, and to the Australian Government in terms of income tax revenue and welfare payments using economic simulation. The simulation model integrated data from the Adalimumab Trial Evaluating Long‐Term Safety and Efficacy for Ankylosing Spondylitis (ATLAS), the Household Income and Labour Dynamics in Australia (HILDA) Survey – Wave 10, and Static Incomes Model (STINMOD). All benefits are expressed in 2014 real Australian dollars.ResultsWe estimated an additional 131 people aged 19–64 with AS (111 males, 20 females) would be in the labour force after using adalimumab for 24 weeks. National benefits consisted of an increase in annual earnings of AU$7.4 million for patients through increased labour force participation, savings of $2 million in annual welfare payments, and an increase of $1.3 million in income tax revenue in 2014 (after 24 weeks).ConclusionAdalimumab therapy generates substantial economic benefits in addition to health benefits for individuals, and savings for government.
Acanthamoeba S13WT relies on its bacterial endosymbiont to backpack human pathogenic bacteria and resist Legionella infection on solid media
Authors: Okubo Torahiko , Matsushita Mizue , Nakamura Shinji , Matsuo Junji , Nagai Hiroki , Yamaguchi Hiroyuki 
Published: April 2018

SummarySoil‐borne amoeba Acanthamoeba S13WT has an endosymbiotic relationship with an environmental Neochlamydia bacterial strain. However, regardless of extensive experiments in liquid media, the biological advantage of the symbiosis remained elusive. We therefore explored the role of the endosymbiont in predator‐prey interactions on solid media. A mixed culture of the symbiotic or aposymbiotic amoebae and GFP‐expressing Escherichia coli or Salmonella Enteritidis was spotted onto the centre of a LB or B‐CYE agar plate preinoculated with a ring of mCherry‐expressing Legionella pneumophila (Legionella ‘wall’). The spread of the amoebae on the plate was assessed using a fluorescence imaging system or scanning electron microscopy. As a result, in contrast to the aposymbiotic amoebae, the symbiotic amoebae backpacked these GFP‐expressing bacteria and formed flower‐like fluorescence patterns in an anticlockwise direction. Other bacteria (Pseudomonas aeruginosa and Stenotrophomonas maltophilia), but not Staphylococcus aureus, were also backpacked by the symbiotic amoebae on LB agar, although lacked the movement to anticlockwise direction. Furthermore, in contrast to the aposymbiotic amoebae, the symbiotic amoebae backpacking the E. coli broke through the Legionella ‘wall’ on B‐CYE agar plates. Thus, we concluded that Acanthamoeba S13WT required the Neochlamydia endosymbiont to backpack human pathogenic bacteria and resist Legionella infection on solid agar.
Initial severity of major depression and efficacy of new generation antidepressants: individual participant data meta‐analysis
Authors: Furukawa T. A. , Maruo K. , Noma H. , Tanaka S. , Imai H. , Shinohara K. , Ikeda K. , Yamawaki S. , Levine S. Z. , Goldberg Y. , Leucht S. , Cipriani A. 
Published: April 2018

Objective
The role of baseline severity as effect modifier in various psychiatric disorders is a topic of controversy and of clinical import. This study aims to examine whether baseline severity modifies the efficacy of various antidepressants for major depression through individual participant data (IPD) meta‐analysis.MethodWe identified all placebo‐controlled, double‐blind randomised trials of new generation antidepressants in the acute phase treatment of major depression conducted in Japan and requested their IPD through the public–private partnerships (PPPs) between the relevant academic societies and the pharmaceutical companies. The effect modification by baseline depression severity was examined through six increasingly complex competing mixed‐effects models for repeated measures.ResultsWe identified eleven eligible trials and obtained IPD from six, which compared duloxetine, escitalopram, mirtazapine, paroxetine or bupropion against placebo (total n = 2464). The best‐fitting model revealed that the interaction between baseline severity and treatment was not statistically significant (coefficient = −0.04, 95% confidence interval: −0.16 to 0.08, P = 0.49). Several sensitivity analyses confirmed the robustness of the findings.ConclusionWe may expect as much benefit from antidepressant treatments for mild, moderate or severe major depression. Clinical practice guidelines will need to take these findings into consideration.
Mandibular mesial root canal morphology using micro‐computed tomography in a Brazilian population
Authors: Marceliano‐Alves Marília F. , Lima Carolina Oliveira , Bastos Ligia Gonçalves do Prado Martins Nayre , Bruno Adilia Maria Vieira , Vidaurre Fernanda , Coutinho Thais Machado , Fidel Sandra Rivera , Lopes Ricardo Tadeu 
Published: April 2018

AbstractTo assess the root canal system morphology of mandibular molars by means of micro‐computed tomography, one hundred and four mandibular first molars were investigated and the following were evaluated: Vertucci's classification, the presence of lateral canals and the number of apical foramina. Mesial root canal surface area and volume were obtained by the CTAn and CTvol software. The type of root canal isthmi was classified applying the Hsu & Kim and Fan criteria. The most frequent root canal configuration was Vertucci type IV (46.2%). Lateral canals were observed in all root canal thirds and the average number of apical foramina was 3.15 ± 1.77. Regarding the presence of isthmus, Types I and II were the most prevalent, according to Hsu & Kim and Fan et al. criteria, respectively. Mesial root canals of mandibular molars showed high morphology variability.
Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model
Authors: Hosgood Sarah A. , Moore Tom , Qurashi Maria , Adams Tom , Nicholson Michael L. 
Published: April 2018

AbstractIn renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival. Hydrogen has antioxidant and anti‐inflammatory properties that can reduce the effects of ischemic injury. The aim of this study was to examine the effects of hydrogen gas administered during reperfusion in a preclinical model of kidney ischemia reperfusion injury. Porcine kidneys underwent 15 min of warm ischemia followed by 22 h of cold ischemia. They were then reperfused for 6 h with whole autologous blood on an ex vivo reperfusion circuit. Paired kidneys were randomized to control (n = 6) (25% oxygen, 5% carbon dioxide, 70% nitrogen) or hydrogen (n = 6) (2% hydrogen, 25% oxygen, 5% carbon dioxide, 68% nitrogen) groups. Tissue, urine, and blood samples were collected at baseline and hourly throughout the reperfusion period. Baseline measurements were similar across groups. Following perfusion, there was no significant difference between control and hydrogen groups in urine output (693 mL vs. 608 mL, P = 0.86), renal blood flow (105.9 vs. 108 mL/min/100g, P = 0.89), acid‐base homeostasis, or creatinine clearance. There was a significant increase in cytokine levels from baseline to 6 h in both groups (IL‐1β P = 0.002; IL‐6 P = 0.004; IL‐8 P = 0.002). However, there were no significant differences in levels of inflammatory cytokines (IL1β, IL‐6, and IL‐8) between the groups. The administration of hydrogen gas did not improve renal function, reduce oxidative damage, or inflammation during the reperfusion of ischemically damaged kidneys.
In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics
Authors: Rigolin Gian Matteo , Saccenti Elena , Guardalben Emanuele , Cavallari Maurizio , Formigaro Luca , Zagatti Barbara , Visentin Andrea , Mauro Francesca R. , Lista Enrico , Bassi Cristian , Lupini Laura , Quaglia Francesca Maria , Urso Antonio , Bardi Maria Antonella , Bonaldi Laura , Volta Eleonora , Tammiso Elisa , Ilari Caterina , Cafforio Luciana , Melandri Aurora , Cavazzini Francesco , Negrini Massimo , Semenzato Gianpietro , Trentin Livio , Foà Robin , Cuneo Antonio 
Published: April 2018

SummaryComplex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high‐risk CLL patients with distinct clinical and biological characteristics.
Factor (F)VIII/VIIa enhances global haemostatic function in the co‐presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor
Authors: Nogami Keiji , Matsumoto Tomoko , Yada Koji , Ogiwara Kenichi , Furukawa Shoko , Shida Yasuaki , Takeyama Masahiro , Shima Midori 
Published: April 2018

SummaryBypassing therapy is essential for the haemostatic management of patients with haemophilia A with inhibitor (PWHA‐inh), but the therapeutic effects are inconsistent. We previously reported that activated prothrombin complex concentrates (aPCC) activated factor (F)VIIIin vitro, and was mediated mainly by the activated FVII (FVIIa) contained in aPCC. We have extended those studies to assess global coagulation in whole blood from 18 PWHA‐inh in the co‐presence of aPCC and FVIII using Ca2+‐triggered rotational thromboelastometry. The clot times (CTs) in the presence of both aPCC (0·05 iu/ml) and recombinant (r)FVIII (1 iu/ml) ex vivo were shortened compared to the aPCC alone (P < 0·01). These enhancing effects of rFVIII were observed, irrespective of recognizing inhibitor epitopes; however, the clot formation time and ‘α’‐angle were not significantly different. In samples from 7 PWHA‐inh post‐infusion of aPCC (70‐80 iu/kg), only the CTs were shortened in the presence of rFVIIIex vivo compared to its absence (P < 0·05), indicating that the enhanced activity centred on the initiation phase of coagulation. Furthermore, experiments in the co‐presence of rFVIIa and rFVIII demonstrated that FVIII accelerated only the CTs. We concluded that FVIII/FVIIa‐related coagulation mechanism enhanced global haemostatic function by the co‐presence of bypassing agents and FVIII in PWHA‐inh.