bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 1596 Keicho Earthquake, a 5‐Day, 300‐km‐Long Sequential Rupture Event in the Median Tectonic Line Fault Zone, Southwestern Japan
Authors: Ikeda Michiharu , Toda Shinji , Onishi Kozo , Nishizaka Naoki , Suzuki Shunsuke 
Published: July 2019

AbstractHistorical accounts and geological surveys suggest that a sequential rupture event occurred in 1596 CE in the Median Tectonic Line fault zone (MTLFZ) in southwestern Japan. During this event, known as the 1596 Keicho earthquake, the rupture probably propagated in two or three sequential stages, similar to a series of events that occurred along the North Anatolian fault during 1939–1999. The detailed rupture process of the 1596 earthquake event is unknown, however, because coseismic seismological, geological, and geodetic observation data are not available. To reconstruct the rupture processes, we integrated data from Coulomb stress change analyses, fault geometrical analyses, historical accounts, and rupture history. The results suggest that the rupture initiated on the Kawakami fault on 1 September 1596 and propagated bilaterally, to the Beppu Bay fault system, which ruptured on 4 September, and to the MTLFZ in eastern Shikoku and the Rokko‐Awaji fault zone and Arima‐Takatsuki Tectonic Line in the Kinki area, which ruptured on 5 September. However, there is a small possibility that the rupture initiated at the western end of the MTLFZ and propagated eastward unilaterally. The propagation of ruptures might be sensitively controlled not only by stress perturbation and fault geometry but also by rupture history. Evaluation of fault rupture behavior from various viewpoints can contribute to the mitigation of future seismic disasters in fault zones where detailed coseismic observation data from the past are lacking.
Regional Superparameterization in a Global Circulation Model Using Large Eddy Simulations
Authors: Jansson Fredrik , van den Oord Gijs , Pelupessy Inti , Grönqvist Johanna H. , Siebesma A. Pier , Crommelin Daan 
Published: July 2019

AbstractAs a computationally attractive alternative for global large eddy simulations (LESs), we investigate the possibility of using comprehensive three‐dimensional LESs as a superparameterization that can replace all traditional parameterizations of atmospheric processes that are currently used in global models. We present the technical design for a replacement of the parameterization for clouds, convection, and turbulence of the global atmospheric model of the European Centre for Medium‐Range Weather Forecasts by the Dutch Atmospheric Large Eddy Simulation model. The model coupling consists of bidirectional data exchange between the global model and the high‐resolution LES models embedded within the columns of the global model. Our setup allows for selective superparameterization, that is, for applying superparameterization in local regions selected by the user, while keeping the standard parameterization of the global model intact outside this region. Computationally, this setup can result in major geographic load imbalance, because of the large difference in computational load between superparameterized and nonsuperparameterized model columns. To resolve this issue, we use a modular design where the local and global models are kept as distinct model codes and organize the model coupling such that all the local models run in parallel, separate from the global model. First simulation results, employing this design, demonstrate the potential of our approach.
Insights Into Intraplate Stresses and Geomorphology in the Southeastern United States
Authors: Murphy Benjamin S. , Liu Lijun , Egbert Gary D. 
Published: July 2019

AbstractThe stress field in the eastern United States is commonly considered to be broadly uniform and due to homogeneous far‐field forces; however, modern and geologic stress indicators in this region show substantial heterogeneity. Using CitcomS to model stresses based on simple input density, temperature, and viscosity fields, we show that local isostasy is key in explaining the intraplate stress field in the southeastern United States. Crustal thickness variations appear to be most important in reproducing observations, although we slightly better match the observed stress field by including variable crustal viscosity informed by magnetotelluric imaging. Our results demonstrate that local gravitational body forces can substantially reorient far‐field stresses and thereby influence patterns of intraplate seismicity. We also show that variable crustal viscosity encourages a steepening of isostatic topography in the southeastern United States; this observation suggests that a sharp boundary in crustal strength may be important in explaining the apparently long‐lived Appalachian topographic escarpment.
Coral bacterial community structure responds to environmental change in a host-specific manner
Authors: Ziegler Maren , Grupstra Carsten G. B. , Barreto Marcelle M. , Eaton Martin , BaOmar Jaafar , Zubier Khalid , Al-Sofyani Abdulmohsin , Turki Adnan J. , Ormond Rupert , Voolstra Christian R. 
Published: July 2019

AbstractThe global decline of coral reefs heightens the need to understand how corals respond to changing environmental conditions. Corals are metaorganisms, so-called holobionts, and restructuring of the associated bacterial community has been suggested as a means of holobiont adaptation. However, the potential for restructuring of bacterial communities across coral species in different environments has not been systematically investigated. Here we show that bacterial community structure responds in a coral host-specific manner upon cross-transplantation between reef sites with differing levels of anthropogenic impact. The coral Acropora hemprichii harbors a highly flexible microbiome that differs between each level of anthropogenic impact to which the corals had been transplanted. In contrast, the microbiome of the coral Pocillopora verrucosa remains remarkably stable. Interestingly, upon cross-transplantation to unaffected sites, we find that microbiomes become indistinguishable from back-transplanted controls, suggesting the ability of microbiomes to recover. It remains unclear whether differences to associate with bacteria flexibly reflects different holobiont adaptation mechanisms to respond to environmental change.
The nasal methylome as a biomarker of asthma and airway inflammation in children
Authors: Cardenas Andres , Sordillo Joanne E. , Rifas-Shiman Sheryl L. , Chung Wonil , Liang Liming , Coull Brent A. , Hivert Marie-France , Lai Peggy S. , Forno Erick , Celedón Juan C. , Litonjua Augusto A. , Brennan Kasey J. , DeMeo Dawn L. , Baccarelli Andrea A. , Oken Emily , Gold Diane R. 
Published: July 2019

AbstractThe nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) and lung function. We find multiple differentially methylated CpGs (FDR < 0.05) and Regions (DMRs; ≥ 5-CpGs and FDR < 0.05) for asthma (285-CpGs), FeNO (8,372-CpGs; 191-DMRs), total IgE (3-CpGs; 3-DMRs), environment IgE (17-CpGs; 4-DMRs), allergic asthma (1,235-CpGs; 7-DMRs) and bronchodilator response (130-CpGs). Discovered DMRs annotated to genes implicated in allergic asthma, Th2 activation and eosinophilia (EPX, IL4, IL13) and genes previously associated with asthma and IgE in EWAS of blood (ACOT7, SLC25A25). Asthma, IgE and FeNO were associated with nasal epigenetic age acceleration. The nasal epigenome is a sensitive biomarker of asthma, allergy and airway inflammation.
Machine learning enables polymer cloud-point engineering via inverse design
Authors: Kumar Jatin N. , Li Qianxiao , Tang Karen Y. T. , Buonassisi Tonio , Gonzalez-Oyarce Anibal L. , Ye Jun 
Published: July 2019

AbstractInverse design is an outstanding challenge in disordered systems with multiple length scales such as polymers, particularly when designing polymers with desired phase behavior. Here we demonstrate high-accuracy tuning of poly(2-oxazoline) cloud point via machine learning. With a design space of four repeating units and a range of molecular masses, we achieve an accuracy of 4 °C root mean squared error (RMSE) in a temperature range of 24–90 °C, employing gradient boosting with decision trees. The RMSE is >3x better than linear and polynomial regression. We perform inverse design via particle-swarm optimization, predicting and synthesizing 17 polymers with constrained design at 4 target cloud points from 37 to 80 °C. Our approach challenges the status quo in polymer design with a machine learning algorithm, that is capable of fast and systematic discovery of new polymers.
Accelerated aging test modeling applied to solar mirrors
Authors: Avenel Coralie , Raccurt Olivier , Gardette Jean-Luc , Therias Sandrine 
Published: July 2019

AbstractThe durability of solar mirrors is a critical factor for the deployment of concentrating solar power plants. Accelerated aging test models currently applied in the polymer, electronic, and photovoltaic fields have recently been reviewed, and the issues of their application to solar mirrors have been discussed. This article first reports the results of temperature, humidity, and light irradiance accelerated aging tests performed to assess the dependent parameters of selected models from the literature. These parameters include the apparent activation energy for the Arrhenius temperature law, the Peck and Eyring coefficients for humidity models and the Schwarzschild coefficient for the irradiance law. The experimental values were then assessed for specular reflectance loss of solar mirrors. Finally, using these parameters, acceleration factors were calculated for solar mirrors. An effective temperature considering the Arrhenius degradation law was used rather than the commonly used mean temperature. This question is also addressed for light irradiance by using the dose instead of the mean value.
Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females
Authors: Potluri Tanvi , Fink Ashley L. , Sylvia Kristyn E. , Dhakal Santosh , Vermillion Meghan S. , vom Steeg Landon , Deshpande Sharvari , Narasimhan Harish , Klein Sabra L. 
Published: July 2019

AbstractVaccine-induced immunity declines with age, which may differ between males and females. Using human sera collected before and 21 days after receipt of the monovalent A/Cal/09 H1N1 vaccine, we evaluated cytokine and antibody responses in adult (18–45 years) and aged (65+ years) individuals. After vaccination, adult females developed greater IL-6 and antibody responses than either adult males or aged females, with female antibody responses being positively associated with concentrations of estradiol. To test whether protection against influenza virus challenge was greater in females than males, we primed and boosted adult (8–10 weeks) and aged (68–70 weeks) male and female mice with an inactivated A/Cal/09 H1N1 vaccine or no vaccine and challenged with a drift variant A/Cal/09 virus. As compared with unvaccinated mice, vaccinated adult, but not aged, mice experienced less morbidity and better pulmonary viral clearance following challenge, regardless of sex. Vaccinated adult female mice developed antibody responses that were of greater quantity and quality and more protective than vaccinated adult males. Sex differences in vaccine efficacy diminished with age in mice. To determine the role of sex steroids in vaccine-induced immune responses, adult mice were gonadectomized and hormones (estradiol in females and testosterone in males) were replaced in subsets of animals before vaccination. Vaccine-induced antibody responses were increased in females by estradiol and decreased in males by testosterone. The benefit of elevated estradiol on antibody responses and protection against influenza in females is diminished with age in both mice and humans.
Age-related differences and sexual dimorphism in canine sleep spindles
Authors: Iotchev Ivaylo Borislavov , Kis Anna , Turcsán Borbála , Tejeda Fernández de Lara Daniel Rodrigo , Reicher Vivien , Kubinyi Enikő 
Published: July 2019

AbstractNon-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investigated a large sample (N = 155) of intact and neutered pet dogs of both sexes, varying in breed and age, searching for spindles in segments of non-REM sleep. We recorded EEG from both a frontal midline electrode (Fz) and a central midline electrode (Cz) in 55.5% of the dogs, in the remaining animals only the Fz electrode was active (bipolar derivation). A similar topography was observed for fast (≥13 Hz) spindle occurrence as in humans (fast spindle number, density on Cz > Fz). For fast spindles, density was higher in females, and increased with age. These effects were more pronounced among intact animals and on Fz. Slow spindle density declined and fast spindle frequency increased with age on Cz, while on Fz age-related amplitude decline was observed. The frequency of fast spindles on Fz and slow spindles on Cz was linked to both sex and neutering, suggesting modulation by sexual hormones. Intact females displayed higher frequencies than males and neutered females. Our findings support the argument that sigma bursts in the canine non-REM sleep are analogous to human sleep spindles, and suggest that slow and fast spindles display different trajectories related to age, of which an increase in frontal fast spindles is unique to dogs.
In situ characterisation of MnS precipitation in high carbon steel
Authors: Tanaka Yasuhiro , Pahlevani Farshid , Moon Suk-Chun , Dippenaar Rian , Sahajwalla Veena 
Published: July 2019

AbstractManganese sulphide (MnS) is one of the major non-metallic inclusions in steel with huge impact on steel property. In the case of high carbon steel, due to higher sulphur content and its brittleness, controlling MnS formation is one of the main issues. MnS has a complicated precipitation mechanism during solidification in liquid and solid steel and at the interface with oxide inclusions. Higher sulphur content, lower melting point and different oxide inclusions in high carbon steel will cause MnS precipitation at different stages. In this study, different stages of MnS precipitation from liquid and/or solid in high carbon steel and at the interface with oxide inclusion were investigated comprehensively via two different types of High Temperature Confocal Scanning Laser Microscope (HTCSLM). Samples were analysed further using SEM-EDS for better understanding the pertaining mechanisms. MnS precipitation on the surface of liquid steel was observed in situ in a HTCSLM by the use of a concentric solidification technique. Additionally, formation of MnS following solidification and at the interfaces of oxide inclusions, was investigated in situ in a HTCSLM, which has a uniform temperature profile across the specimen. These comprehensive descriptions about different stages of MnS precipitation in high carbon steel have been conducted for the first time and provide crucial information for controlling MnS morphology in high carbon steel.
Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep
Authors: Draghi V. , Wassink G. , Zhou K. Q. , Bennet L. , Gunn A. J. , Davidson J. O. 
Published: July 2019

AbstractIt is widely believed that rewarming slowly after therapeutic hypothermia for hypoxic-ischemic (HI) encephalopathy can improve outcomes, but its impact on white matter injury after HI is unclear. Fetal sheep (0.85 gestation) received 30 min ischemia-normothermia (n = 8), or hypothermia from 3–48 h with rapid spontaneous rewarming over 1 h (ischemia-48 h hypothermia, n = 8), or 48 h with slow rewarming over 24 h (ischemia-slow rewarming, n = 7) or 72 h with rapid rewarming (ischemia-72 h hypothermia, n = 8). Ischemia was associated with loss of total and mature oligodendrocytes and reduced area fraction of myelin basic protein (MBP) and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase; immature/mature oligodendrocytes) and increased microglia and astrocytes. Total numbers of oligodendrocytes were increased by all hypothermia protocols but only ischemia-72 h hypothermia attenuated loss of mature oligodendrocytes. All hypothermia protocols similarly increased the area fraction of MBP, whereas there was only an intermediate effect on the area fraction of CNPase. Microglia were suppressed by all hypothermia protocols, with the greatest reduction after ischemia-72 h hypothermia, and an intermediate effect after ischemia-slow rewarming. By contrast, induction of astrocytes was significantly reduced only after ischemia-slow rewarming. In conclusion, slow rewarming after hypothermia did not improve oligodendrocyte survival or myelination or suppression of microgliosis compared to fast rewarming, but modestly reduced astrocytosis.
Centrality in Complex Networks with Overlapping Community Structure
Authors: Ghalmane Zakariya , Cherifi Chantal , Cherifi Hocine , Hassouni Mohammed El 
Published: July 2019

AbstractIdentifying influential spreaders in networks is an essential issue in order to prevent epidemic spreading, or to accelerate information diffusion. Several centrality measures take advantage of various network topological properties to quantify the notion of influence. However, the vast majority of works ignore its community structure while it is one of the main features of many real-world networks. In a recent study, we show that the centrality of a node in a network with non-overlapping communities depends on two features: Its local influence on the nodes belonging to its community, and its global influence on the nodes belonging to the other communities. Using global and local connectivity of the nodes, we introduced a framework allowing to redefine all the classical centrality measures (designed for networks without community structure) to non-overlapping modular networks. In this paper, we extend the so-called “Modular Centrality” to networks with overlapping communities. Indeed, it is a frequent scenario in real-world networks, especially for social networks where nodes usually belong to several communities. The “Overlapping Modular Centrality” is a two-dimensional measure that quantifies the local and global influence of overlapping and non-overlapping nodes. Extensive experiments have been performed on synthetic and real-world data using the Susceptible-Infected-Recovered (SIR) epidemic model. Results show that the Overlapping Modular Centrality outperforms its alternatives designed for non-modular networks. These investigations provide better knowledge on the influence of the various parameters governing the overlapping community structure on the nodes’ centrality. Additionally, two combinations of the components of the Overlapping Modular Centrality are evaluated. Comparative analysis with competing methods shows that they produce more efficient centrality scores.
Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein
Authors: Bayart E. , Flacco A. , Delmas O. , Pommarel L. , Levy D. , Cavallone M. , Megnin-Chanet F. , Deutsch E. , Malka V. 
Published: July 2019

AbstractRadiotherapy is a cornerstone of cancer management. The improvement of spatial dose distribution in the tumor volume by minimizing the dose deposited in the healthy tissues have been a major concern during the last decades. Temporal aspects of dose deposition are yet to be investigated. Laser-plasma-based particle accelerators are able to emit pulsed-proton beams at extremely high peak dose rates (~109 Gy/s) during several nanoseconds. The impact of such dose rates on resistant glioblastoma cell lines, SF763 and U87-MG, was compared to conventionally accelerated protons and X-rays. No difference was observed in DNA double-strand breaks generation and cells killing. The variation of the repetition rate of the proton bunches produced an oscillation of the radio-induced cell susceptibility in human colon carcinoma HCT116 cells, which appeared to be related to the presence of the PARP1 protein and an efficient parylation process. Interestingly, when laser-driven proton bunches were applied at 0.5 Hz, survival of the radioresistant HCT116 p53−/− cells equaled that of its radiosensitive counterpart, HCT116 WT, which was also similar to cells treated with the PARP1 inhibitor Olaparib. Altogether, these results suggest that the application modality of ultrashort bunches of particles could provide a great therapeutic potential in radiotherapy.
Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk
Authors: Vaish Utpreksha , Kumar Avinash A. , Varshney Swati , Ghosh Shreya , Sengupta Shantanu , Sood Chandni , Kar Hemanta K. , Sharma Pankaj , Natarajan Vivek T. , Gokhale Rajesh S. , Rani Rajni 
Published: July 2019

AbstractTranslation of genes is regulated by many factors including microRNAs (miRNAs). miRNA profiling of lesional and non-lesional epidermal RNA from 18 vitiligo patients revealed significant upregulation of 29 miRNAs in the lesional epidermis, of which 6 miRNAs were transfected in normal human epidermal keratinocytes (NHEKs) to study their downstream effects using quantitative proteomics. Many proteins involved in oxidative stress, Vesicle trafficking, Cellular apoptosis, Mitochondrial proteins and Keratins were regulated after miRNA transfections in the keratinocytes. However, tyrosinase related protein-1 (TRP1/TYRP1), a melanogenesis protein, was consistently downregulated in NHEKs by all the six miRNAs tested, which was quite intriguing. TRP1 was also downregulated in lesional epidermis compared with non-lesional epidermis. Since melanocytes synthesize and transfer melanosomes to the surrounding keratinocytes, we hypothesized that downregulation of TRP1 in NHEKs may have a role in melanosome transfer, which was confirmed by our co-culture experiments. Downregulation of TRP1 in keratinocytes negatively affected the melanosome transfer from melanocytes to keratinocytes resulting in melanin accumulation which may be leading to melanin induced cytotoxicity in melanocytes. Regulation of key processes involved in aetiopathogenesis of vitiligo along with TRP1 suggests that miRNAs act in an integrated manner which may be detrimental for the loss of melanocytes in vitiligo.