bluuebunny/crossref_metadata_2025_split huggingface dataset:
VITAMIN D TRENDS IN THE PEDIATRIC ORTHOPAEDIC POPULATION: A SURVEY
Authors: Williams Kevin A. , Horan Michael 
Published: March 2019

Background: Vitamin D deficiency is a global issue, affecting adults and children of all ages, races and genders. Within the last decade, multiple studies have demonstrated the potential health benefits of vitamin D supplementation including improved bone health, reduced fracture risk, protection from autoimmune disease, and decreased cancer risk. Because of the prevalence of vitamin D deficiency in pediatric populations despite recent evidence of increased vitamin D supplementation in the US, our goal is to assess the knowledge of current vitamin D recommendations among Pediatric Society of North America (POSNA) members. It is our purpose to use the data to increase awareness and understanding of vitamin D amongst all pediatric providers. Methods: Our survey was distributed to 1316 POSNA members via a series of 2 email requests in which they were invited to participate in the survey on the Survey Monkey website. Their participation was entirely voluntary and they agreed to participate by responding positively on the first page of the survey. The data was depersonalized and analyzed via chi square and Fisher’s exact testing. Results: 395 responses were recorded. 9 participants opted out of the survey. 69% of participants rated their vitamin D knowledge as fair to good. 68% of participants have been in practice over ten years and represented most US geographic regions fairly equally. Most estimate that over 25% of their practice is vitamin D deficient with about a 50% compliance rate of supplementation. Over 30% of participants feel vitamin D management is mostly the role of the pediatrician, however 64% of participants discuss or check vitamin D levels in their practice for patients with repeat fractures, medical comorbidities, or nonunions most commonly. Conclusion: Survey participants demonstrated a wide variety of responses indicating their understanding of vitamin D testing and supplementation. Although providers estimate a high deficiency rate, many do not routinely check vitamin D. When they do check, there is no standard indication for testing or supplementation and many believe this to be the role of the pediatrician or endocrinologist. More studies are needed to provide a standardized protocol for vitamin D testing/supplementation in the pediatric orthopaedic literature.
ANATOMICAL DISSECTION AND CT IMAGING OF THE ANTERIOR CRUCIATE AND MEDIAL COLLATERAL LIGAMENT FOOTPRINT ANATOMY IN SKELETALLY IMMATURE CADAVER KNEES
Authors: Shea Kevin , Cannamela Peter C. , Dingel Aleksei , Fabricant Peter D. , Polousky John D. , Anderson Allen , Ganley Theodore J. 
Published: March 2019

Background: Anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries in skeletally immature patients are increasingly recognized and surgically treated. However, the relationship between the footprint anatomy and the physes are not clearly defined. The purpose of this study was to identify the origin and insertion of the ACL and MCL, and define the footprint anatomy in relation to the physes in skeletally immature knees. Methods: Twenty-nine skeletally immature knees from 16 human cadaver specimens were dissected and divided into two groups: Group A (ages 2-5 years), and Group B (ages 7-11 years). Metallic markers were placed to mark the femoral and tibial attachments of the ACL and MCL. CT scans were obtained for each specimen used to measure the distance from the center of the ligament footprints to the respective distal femoral and proximal tibial physes. Results: Median distance from the ACL femoral epiphyseal origin to the distal femoral physis was 0.30 cm (interquartile range, 0.20 cm to 0.50 cm) and 0.70 cm (interquartile range, 0.45 cm to 0.90 cm) for Groups A and B, respectively. The median distance from the ACL epiphyseal tibial insertion to the proximal tibial physis for Groups A and B were 1.50 cm (interquartile range, 1.40 cm to 1.60 cm) and 1.80 cm (interquartile range, 1.60 cm to 1.85 cm), respectively. Median distance from the MCL femoral origin on the epiphysis to the distal femoral physis was 1.20 cm (interquartile range, 1.00 cm to 1.20 cm) and 0.85 cm (interquartile range, 0.63 cm to 1.00 cm) for Groups A and B, respectively. Median distance from the MCL insertion on the tibial metaphysis to the tibial physis was 3.05 cm (interquartile range, 2.63 cm to 3.30 cm) and 4.80 cm (interquartile range, 3.90 cm to 5.10 cm) for Groups A and B, respectively. Conclusion: Surgical reconstruction is a common treatment for ACL injury, and occasionally MCL reconstruction or repair is also required. Cadaveric dissection and CT scanning of exceptionally rare pediatric tissue clearly defines the location of the ACL and MCL with respect to the femoral and tibial physes, and may guide surgeons for physeal respecting procedures for both ACL reconstruction, and ACL repair procedures. Clinical Relevance: In addition to ACL reconstruction, recent basic science and clinical research suggest that ACL repair may be more commonly performed in the future. MCL repair and reconstruction is also occasionally required in skeletally immature patients. This information may be useful to help surgeons avoid or minimize physeal injury during ACL/MCL reconstructions and/or repair in skeletally immature patients. [Figure: see text][Figure: see text][Figure: see text][Figure: see text]
BODY IMAGE AND ITS ROLE IN YOUTH SPORTS PARTICIPATION
Authors: Davelaar Cassidy Foley 
Published: March 2019

Background: Pediatric patients with inflammatory conditions often present with single or multifocal joint pain. Assessment of these patients at our institution revealed a possible association between femoroacetabular impingement (FAI) and inflammatory comorbidities. The purpose of this study was to investigate the prevalence and unique characteristic morphology of FAI in pediatric patients with inflammatory comorbidities. Methodology: A retrospective review was conducted on a consecutive series of 105 patients diagnosed with FAI in our institution’s adolescent hip clinic from January 2016 to March 2018. Patients with an inflammatory comorbidity were identified. Femoral head-neck junction morphology was assessed qualitatively and with standard radiographic measures for FAI. Results: Seven patients (6.7% of diagnosed patients), with eight symptomatic hips, were found to have FAI and an inflammatory comorbidity. These diagnoses included Crohn’s disease, Celiac disease, juvenile idiopathic arthritis, Type 1 diabetes mellitus and hypothyroidism. All seven patients had cam deformities. Qualitative assessment revealed that most patients had a characteristic head-neck morphology that was unique to this subset of patients, with a prominent and “sharp-edged” bump at the head-neck junction (See Figure 1). Radiographic analysis of the symptomatic hips revealed a mean alpha angle of 81.3o (±8.7 o), mean LCEA of 33.1o (±8.4 o) and mean femoral offset of 0.07 (±0.05). There was no significant difference in the radiographic measurements between symptomatic and asymptomatic hips in these patients. Conclusion: This is the first study to identify an association between FAI and inflammatory comorbidities in pediatric patients, with a prevalence of 6.7% at our institution. Given the relative rarity of inflammatory comorbidities in the general pediatric patient, this represents an unexpectedly high association. These patients presented with a unique head-neck morphology characterized by a more prominent and “sharp-edged” cam lesion than the typical morphology seen in patients without an inflammatory comorbidity. This study raises questions regarding the possible role of physeal inflammation in the development of cam deformities and indicates a need for further studies investigating the relationship between systemic inflammatory disorders and FAI. [Figure: see text]
DEFINING A SAFE ZONE FOR ALL INSIDE LATERAL MENISCUS REPAIRS IN PEDIATRIC PATIENTS: A MAGNETIC RESONANCE IMAGING STUDY
Authors: Beck Jennifer , Shifflett Kendall , Greg Danielle , Ebramzadeh Edward , Bowen Richard E. 
Published: March 2019

Purpose All-inside posterior horn lateral meniscal (PHLM) repair puts the popliteal neurovascular bundle (PVNB) at risk of injury by meniscal repair devices. The purpose of this study was to establish a safe zone of all-inside meniscal fixation in pediatric patients using MRI measurements between the popliteus tendon (PT) and popliteal neurovascular bundle (PNVB). We hypothesize that males and older age groups will have a larger distance between PT and PNVB. Methods Axial MRIs of 250 pediatric (5-16 yrs.) patients were retrospectively reviewed. Patients were grouped by age: group I (5-7yrs.): 61; II (8-10yrs.): 59; III (11-13yrs.): 60; IV (14-16yrs.): 70. At the level of the lateral meniscus, two lines starting at the lateral patella tendon border ending at the medial edge of the PT (D1) and the lateral edge of the PNVB (D2) were made on an axial knee MRI. D3 connected D1 to D2 at the meniscocapsular junction of the PHLM. D4 was derived geometrically, parallel and 8 mm anterior to D3 simulating the anterior edge of the PHLM. Results Analysis showed significant correlation between age and sex for D3 (p<0.0001). For D3, there were significant differences among all age groups, except between groups III and IV. Average (STD) D3 for age groups was: 14.1mm(3.1), 15.8(2.5), 17.0(3.3), 17.2(3.1). For D4, the average (STD) was: 11.9 mm(2.9); 13.9(2.5); 15.4(3.0); 15.2(2.9). There was significant difference in D3 and D4 in males versus females (17.6 vs 15.7 mm; p <0.001; 14.9 vs 13.2; p <0.001), particularly in III and IV (17.0 vs 13.8 and 16.8 vs 13.9). Conclusions This study provides normative data of the distance between popliteal neurovascular bundle and popliteus tendon at the meniscocapsular junction (D3) and anterior edge of the posterior horn lateral meniscus (D4) with the knee in full extension. Combined with previous studies showing the addition of knee flexion increases the distance between the meniscus and the neurovascular bundle, surgeons can use this data to improve safety of posterior horn lateral meniscus repair in pediatric patients.
CONTINUED CLAVICULAR GROWTH DURING ADOLESCENCE AND EARLY ADULTHOOD
Authors: Hughes Jessica , Newton Peter , Bastrom Tracey , Pennock Andrew 
Published: March 2019

Background: As more adults undergo surgical fixation of clavicle fractures, there is a renewed interest in the management of adolescent fractures. While the medial clavicular physis does not fuse until 23-25 years, literature reports limited residual growth of the clavicle during adolescence. The aim of this study is to evaluate the longitudinal clavicular growth on serial thoracic radiographs in adolescents and young adults. Methods: A review was performed on two cohorts of patients: 1. Scheuermann’s Kyphosis patients and 2. A prospectively collected adolescent idiopathic scoliosis registry. Patients, 10-25yrs old, were included if they had serial thoracic radiographs over 5 years with at least 3 serial radiographs capturing the entire length of at least one clavicle. Radiographs were excluded for malrotation. Known surgical implant dimensions were utilized to normalize measurements. The measurements were organized into 3 groups: 12-15yrs, 16-19yrs and =20yrs. The overall growth, the growth per year and the growth percentage per year were calculated for each clavicle. Results: Fifty-seven patients met the inclusion criteria (22 males and 35 female). For male patients, age 12-15yrs, the clavicular growth was 5.2 mm/yr and 4.2%/yr, age 16-19yrs: 3.0 mm/yr or 2.3%/yr and for ages 20-25yrs: 1.7mm/yr or 1.4%/yr. For female patients, 12-15yrs, there was 4.6mm/yr and 3.9%/yr, 16-19yrs: 2.0mm/yr or 1.6%/yr, and for age 20-25yrs: 0.8mm/yr or 0.6%/yr. We were unable to detect an age of terminal growth for either gender because residual growth was still ongoing in most patients of the oldest group. Conclusion/Significance: This study suggests that there is continued growth potential of the clavicle after the age of 18yrs and as such more remodeling potential during adolescence than may have otherwise been appreciated. It is unclear how this data will influence surgical decision making in clavicle fracture treatment.
THE DISCRIMINATE ABILITY OF THE PEDIATRIC ADOLESCENT SHOULDER SURVEY (PASS)
Authors: Bastrom Tracey , Pennock Andrew , Edmonds Eric W. 
Published: March 2019

Purpose: The purpose of this study was to examine whether improvements in the Pediatric and Adolescent Shoulder Survey (PASS) are seen at 3 months following surgical treatment for shoulder instability and whether the PASS can discriminate between patients with differing outcomes based on clinical exam and the single assessment numeric evaluation (SANE). Performance of the PASS was contrasted with an adult validated tool, the quickDASH. Methods: Patients who underwent surgical treatment for shoulder instability with completed PASS forms available at pre-operative and 3 months post-operative (range 2.5-4.5mos) were included in this review. The PASS consists of 13 questions that assess (in child friendly language) symptoms, limitations, need for compensatory mechanisms, and emotional distress related to shoulder dysfunction. Responses are on a 0-5 or 0-10 scale with a score calculation based on percentage of total possible points (100% indicates no/minimal impact on quality of life from shoulder dysfunction). Patients were grouped based on range of motion or strength (within 10 degrees to contralateral extremity or no discrepancy in strength score was considered no deficit) and SANE score (=80% vs <80%) at the 3-month visit. Alpha was set at p<0.05 to declare significance. Results: 50 patients with a mean age of 16 years (range 13.5-18 yrs) were identified in this review with a mean post-operative follow-up of 3.2 ± 0.5 months. Scores on the PASS improved significantly from pre-operative (57 ± 16%) to post-operative (74 ± 16%, p<0.001). The quickDASH similarly showed improvement (27 ± 16 pre vs 18 ± 16 post, p=0.003) although the magnitude of the effect for the PASS was larger (f=0.84 for PASS vs f=0.48 for quickDASH). Ceiling effect (>15% reporting the highest score) was observed at 3 months with the quickDASH (16% with top score), but not with the PASS (4%, p=0.03). While both tools were able to discriminate between patients with SANE score =80% vs <80%, the difference in quickDASH score between patients with/without diminished motion did not reach significance (p=0.07, Table). Conclusion: The PASS shows anticipated improvements in shoulder function following surgical intervention for instability without ceiling effects. The PASS is able to discriminate between patients with differing post-operative outcomes at 3 months following surgery. [Table: see text]
TIBIAL TUBERCLE FRACTURES IN CHILDREN AND ADOLESCENTS
Authors: Haber Daniel B. , Tepolt Frances , McClincy Michael , Kalish Leslie , Kocher Mininder S. 
Published: March 2019

Background: Tibial tubercle fractures are uncommon sports related injuries. Only small series are reported in the literature. The purpose of this study is to report patient characteristics, fracture types, treatment methods, and clinical outcomes of children and adolescents treated for tibial tubercle fractures. Methods: Patients age 18 and under treated for tibial tubercle fractures at a single institution from 1995 to 2015 were identified and their medical records were retrospectively reviewed. Clinical and radiographic outcomes were reported for patients with minimum follow up of 6 months. Results: Two-hundred thirty-six tibial tubercle fractures were identified in 228 patients, 198 (86%) of whom were males. Mean age was 14.3 years (range 7.7-17.6). Mean body mass index (BMI) was 25.0 (range 16.1-38.9). Osgood-Schlatter disease was identified in 72 (31%) cases and was most commonly associated with type I fractures (p<0.001). Two-hundred and three fractures (86%) occurred while participating in athletics, most commonly basketball (87, 43%). Thirty percent of fractures occurred while landing, 26% resulted from a direct blow to the leg, and 22% occurred while jumping. Type III fractures were most common (96, 41%) followed by type I fractures (67, 29%). Initial treatment was surgical for 157 (67%) fractures. Type I fractures were most commonly treated non-operatively (91%) and types II-V fractures were most commonly treated surgically (89%, p<0.001). Operative fractures were associated with higher BMI z-scores (mean 1.16, p=0.05) than those treated non-operatively. Compartment syndrome was identified in 4 (2%) patients, 3 of which were had type IV fractures. Eighty-eight percent of patients returned to sports. Among those treated operatively, 55% had hardware removed and 7% developed post-operative infection. At last follow up, 45% of surgical patients reported pain on palpation at the tibial tubercle and 26% reported pain with squatting. Conclusions: Tibial tubercle fractures are sports related injuries and occur most commonly in adolescent males. They are associated with Osgood-Schlatter disease, a higher than average BMI, and a small but relevant risk of compartment syndrome, particularly in type IV fractures. Whether treated surgically or non-surgically, most patients return to sports despite a high incidence of post-treatment pain at the tibial tubercle.
Accuracy and Reliability of The Visual Assessment of Patellar Tracking
Authors: Best Matthew , Tanaka Miho Jean , Demehri Shadpour , Cosgarea Andrew J. 
Published: March 2019

Objectives: Clinicians treating patients with patellar instability describe abnormal tracking as a “J sign” when the patella exhibits excessive lateral displacement as the knee is actively extended. The purpose of this study is to determine the accuracy and reliability of the visual assessment of patellar tracking among patellofemoral experts when compared to objective radiographic measurements. Methods: Active knee extension was video recorded and a dynamic CT scan (4D CT) was obtained in study patients being evaluated for patellar instability. Patellar bisect offset (BO) was measured directly from the 4D CT at 10-degree increments from 0-50 degrees of flexion. The greatest BO value was used to determine quadrants of lateral translation. Practicing orthopedic surgeons from the International Patellofemoral Study Group (IPSG) were asked to view videos and determine the presence or absence of maltracking (2 or more quadrants of lateral translation) in 10 single-knee videos (qualitative analysis). Participants were then asked to grade patella tracking in 20 different single-knee videos (quantitative analysis). J-sign grade was defined as follows: grade 0 - less than 1 patellar quadrant of lateral translation; grade 1 - at least 1 but less than 2 quadrants; grade 2 - at least 2 but less than 3 quadrants; grade 3 - 3 or more quadrants lateral translation. Results: Thirty-two practicing orthopedic surgeon IPSG members completed the survey. In the qualitative analysis, the videos were correctly identified as demonstrating patellar maltracking 68% of the time (free marginal kappa= 0.44). In the quantitative analysis, 53% of survey participants identified grade 3 J sign correctly, 51% correctly identified grade 2, 48% correctly identified grade 1, and 68% correctly identified grade 0 (free marginal kappa= 0.42). Conclusion: This is the first study to compare visual assessment of patellar tracking with objective BO measurements from 4D CT. Using visual assessment alone, patellofemoral experts were able to correctly identify the presence of patellar maltracking in only two-thirds of the videos and were able to correctly grade patellar maltracking in only half. There is inadequate interobserver agreement (free marginal kappa<0.70) to support the use visual assessment alone in determining the presence or degree of patellar maltracking, reinforcing the importance of objective radiographic measurements.
PTENα promotes neutrophil chemotaxis through regulation of cell deformability
Authors: Li Yunqiao , Jin Yuan , Liu Bowen , Lu Dan , Zhu Minglu , Jin Yan , McNutt Michael A. , Yin Yuxin 
Published: March 2019

Abstract
Neutrophils are a major component of immune defense and are recruited through neutrophil chemotaxis in response to invading pathogens. However, the molecular mechanism that controls neutrophil chemotaxis remains unclear. Here, we report that PTENα, the first isoform identified in the PTEN family, regulates neutrophil deformability and promotes chemotaxis of neutrophils. A high level of PTENα is detected in neutrophils and lymphoreticular tissues. Homozygous deletion of PTENα impairs chemoattractant-induced migration of neutrophils. We show that PTENα physically interacts with cell membrane cross-linker moesin through its FERM domain and dephosphorylates moesin at Thr558, which disrupts the association of filamentous actin with the plasma membrane and subsequently induces morphologic changes in neutrophil pseudopodia. These results demonstrate that PTENα acts as a phosphatase of moesin and modulates neutrophil-mediated host immune defense. We propose that PTENα signaling is a potential target for the treatment of infections and immune diseases.