bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic profiling of sourdough fermented wheat and rye bread
Authors: Koistinen Ville M. , Mattila Outi , Katina Kati , Poutanen Kaisa , Aura Anna-Marja , Hanhineva Kati 
Published: April 2018

AbstractSourdough fermentation by lactic acid bacteria is commonly used in bread baking, affecting several attributes of the final product. We analyzed whole-grain wheat and rye breads and doughs prepared with baker’s yeast or a sourdough starter includingCandida milleri,Lactobacillus brevisandLactobacillus plantarumusing non-targeted metabolic profiling utilizing LC–QTOF–MS. The aim was to determine the fermentation-induced changes in metabolites potentially contributing to the health-promoting properties of whole-grain wheat and rye. Overall, we identified 118 compounds with significantly increased levels in sourdough, including branched-chain amino acids (BCAAs) and their metabolites, small peptides with high proportion of BCAAs, microbial metabolites of phenolic acids and several other potentially bioactive compounds. We also identified 69 compounds with significantly decreased levels, including phenolic acid precursors, nucleosides, and nucleobases. Intensive sourdough fermentation had a higher impact on the metabolite profile of whole-grain rye compared to milder whole-grain wheat sourdough fermentation. We hypothesize that the increased amount of BCAAs and potentially bioactive small peptides may contribute to the insulin response of rye bread, and in more general, the overall protective effect against T2DM and CVD.
Graphene wrinkle effects on molecular resonance states
Authors: Nirmalraj Peter N. , Thodkar Kishan , Guerin Sarah , Calame Michel , Thompson Damien 
Published: April 2018

AbstractWrinkles are a unique class of surface corrugations present over diverse length scales from Kinneyia-type wrinkles in Archean-era sedimentary fossils to nanoscopic crinkling in two-dimensional crystals. Lately, the role of wrinkles on graphene has been subject to debate as devices based on graphene progress towards commercialization. While the topology and electronic structure of graphene wrinkles is known, data on wrinkle geometrical effects on molecular adsorption patterns and resonance states is lacking. Here, we report molecular superstructures and enhancement of free-molecular electronic states of pentacene on graphene wrinkles. A new trend is observed where the pentacene energy gap scales with wrinkle height, as wrinkles taller than 2 nm significantly screen metal induced hybridization. Combined with density functional theory calculations, the impact of wrinkles in tuning molecular growth modes and electronic structure is clarified at room-temperature. These results suggest the need to rethink wrinkle engineering in modular devices based on graphene and related 2D materials interfacing with electronically active molecules.
Vortices enable the complex aerobatics of peregrine falcons
Authors: Gowree Erwin R. , Jagadeesh Chetan , Talboys Edward , Lagemann Christian , Brücker Christoph 
Published: April 2018

AbstractThe peregrine falcon (Falco peregrinus) is known for its extremely high speeds during hunting dives or stoop. Here we demonstrate that the superior manoeuvrability of peregrine falcons during stoop is attributed to vortex-dominated flow promoted by their morphology, in the M-shape configuration adopted towards the end of dive. Both experiments and simulations on life-size models, derived from field observations, revealed the presence of vortices emanating from the frontal and dorsal region due to a strong spanwise flow promoted by the forward sweep of the radiale. These vortices enhance mixing for flow reattachment towards the tail. The stronger wing and tail vortices provide extra aerodynamic forces through vortex-induced lift for pitch and roll control. A vortex pair with a sense of rotation opposite to that from conventional planar wings interacts with the main wings vortex to reduce induced drag, which would otherwise decelerate the bird significantly during pull-out. These findings could help in improving aircraft performance and wing suits for human flights.
ShinyR-DAM: a program analyzing Drosophila activity, sleep and circadian rhythms
Authors: Cichewicz Karol , Hirsh Jay 
Published: April 2018

AbstractWe developed a web application ShinyR-DAM for analyzing Drosophila locomotor activity, sleep and circadian rhythms recorded by the Drosophila Activity Monitor (DAM) system (TriKinetics, Waltham, MA). Comparing with the existing programs for DAM data analysis, ShinyR-DAM greatly decreases the complexity and time required to analyze the data, producing informative and customizable plots, summary tables, and data files for statistical analysis. Our program has an intuitive graphical user interface that enables novice users to quickly perform complex analyses.
Formation of the terrestrial planets in the solar system around 1 au via radial concentration of planetesimals
Authors: Ogihara Masahiro , Kokubo Eiichiro , Suzuki Takeru K. , Morbidelli Alessandro 
Published: April 2018

Context. No planets exist inside the orbit of Mercury and the terrestrial planets of the solar system exhibit a localized configuration. According to thermal structure calculation of protoplanetary disks, a silicate condensation line (~1300 K) is located around 0.1 au from the Sun except for the early phase of disk evolution, and planetesimals could have formed inside the orbit of Mercury. A recent study of disk evolution that includes magnetically driven disk winds showed that the gas disk obtains a positive surface density slope inside ~1 au from the central star. In a region with positive midplane pressure gradient, planetesimals undergo outward radial drift.
Aims. We investigate the radial drift of planetesimals and type I migration of planetary embryos in a disk that viscously evolves with magnetically driven disk winds. We show a case in which no planets remain in the close-in region.
Methods. Radial drifts of planetesimals are simulated using a recent disk evolution model that includes effects of disk winds. The late stage of planet formation is also examined by performing N-body simulations of planetary embryos.
Results. We demonstrate that in the middle stage of disk evolution, planetesimals can undergo convergent radial drift in a magnetorotational instability (MRI)-inactive disk, in which the pressure maximum is created, and accumulate in a narrow ring-like region with an inner edge at ~0.7 au from the Sun. We also show that planetary embryos that may grow from the narrow planetesimal ring do not exhibit significant type I migration in the late stage of disk evolution.
Conclusions. The origin of the localized configuration of the terrestrial planets of the solar system, in particular the deficit of close-in planets, can be explained by the convergent radial drift of planetesimals in disks with a positive pressure gradient in the close-in region.
Ich sehe… was?
Authors: Sengebusch Jürgen , Herzog Michael 
Published: April 2018

SummaryMeist sind ältere Menschen betroffen, jedoch beobachtet man, dass auch immer mehr Jüngere daran erkranken. Die Hauterscheinung betrifft in der Regel Stellen, die viel der Sonne ausgesetzt sind. Zu Beginn verwechselt man sie nicht selten mit schlecht heilenden Wunden, Keratosen oder Fibromen.
Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects
Authors: Taïeb David , Timmers Henri , Pacak Karel 
Published: April 2018

AbstractThe mitochondrial enzyme succinate dehydrogenase (SDH) acts as a tumor suppressor. Biallelic inactivation of one of the genes encoding for SDH subunits (collectively named SDHx) leads to complete loss of the protein function and the development of diverse group of tumors. Pheochromocytomas-paragangliomas are the prime example of hereditary tumors caused by SDH deficiency. In this review, we discuss the roles of imaging examinations, and illustrate new insights into genotype-imaging phenotype relationships.
¿Podemos Mejorar La Cicatrización de un Desgarro Muscular Masivo?
Authors: Vaisman Burucker Alex , Scheu Goncalves Maximiliano , Araya Proboste Ignacio , Calvo Mena Rafael , Figueroa Poblete David , Gallegos Angulo Marcela , Calvo Rodríguez Rafael , Conget Molina Paulette 
Published: April 2018

Objetivos Evaluar macroscópica e histológicamente la cicatrización muscular utilizando Dexametasona (DEX) o Traumeel (TRM), en un modelo experimental animal.
Material y Métodos Estudio experimental en 45 ratones BKS. Se seccionó transversal y completamente el cuádriceps derecho en todos los animales. Se definieron 3 grupos de estudio de 15 ratones cada uno, un grupo control, un grupo tratado con Dexametasona y uno con Traumeel. Los animales fueron sacrificados a las 1,2 y 4 semanas después del procedimiento y se les extrajo ambos cuádriceps (derecho como intervención e izquierdo como control) y luego fueron analizados macroscópica e histológicamente por un patólogo calificado, de manera ciega. Los datos se analizaron estadísticamente con el test de Kruskal - Wallis (p < 0,05), utilizando el programa Stata V12.1.
Resultados Macroscopía: A la semana, en todos los grupos se evidenció ausencia de cicatrización con gap persistente. A la segunda semana, se evidencia cicatrización inicial sin gap en todos los grupos. A las 4 semanas todas las muestras estaban cicatrizadas. Histología: La administración de Dexametasona disminuye el infiltrado inflamatorio y aumenta las fibras regenerativas, pero induce mayor fibrosis y pérdida de masa muscular. La adición de Traumeel aumenta la cantidad de fibras regenerativas, pero incrementa el infiltrado inflamatorio.
Conclusiones A las 4 semanas ninguno de los grupos de estudio presentó regeneración muscular completa, con resultados macroscópicos e histológicos variables.
Nivel de Evidencia Estudio experimental.
Neuroparacoccidioidomycosis: Case Report and Literature Review
Authors: Morais Marcus , Georgeto Sérgio , Haddad Marcelo , Amorim José , Scaliante Luis , Paula Anderson , Andrade Igor , Aguiar Paulo 
Published: April 2018

Introduction Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis, and it can compromise the central nervous system (CNS) in 10–27% of all cases.
Case Report A 31-year-old man presented to the Emergency Department with headache, left-sided weakness, clonus at the ankle and a positive Babinski sign. Head computed tomography (CT) and magnetic resonance imaging (MRI) scans showed a 5.1 × 3.8 cm lobulated lesion with areas of liquefaction in the right centrum semiovale.
Discussion Central nervous system PCM can mimic a brain tumor, and most cases are diagnosed by biopsy of the lesion. The treatment includes antibiotics, but some cases require surgery.
Conclusion Due to high morbimortality rates, the diagnosis must be considered, and early treatment started in patients who live in rural regions endemic for PCM when a ring-enhancing mass associated with perilesional edema is observed on MRI scans.
Factors Affecting Acceptance of Hospital Information Systems Based on Extended Technology Acceptance Model: A Case Study in Three Paraclinical Departments
Authors: Nadri Hamed , Rahimi Bahlol , Lotfnezhad Afshar Hadi , Samadbeik Mahnaz , Garavand Ali 
Published: April 2018

Objective Regardless of the acceptance of users, information and communication systems can be considered as a health intervention designed to improve the care delivered to patients. This study aimed to determine the adoption and use of the extended Technology Acceptance Model (TAM2) by the users of hospital information system (HIS) in paraclinical departments including laboratory, radiology, and nutrition and to investigate the key factors of adoption and use of these systems.
Materials and Methods A standard questionnaire was used to collect the data from nearly 253 users of these systems in paraclinical departments of eight university hospitals in two different cities of Iran. A total of 202 questionnaires including valid responses were used in this study (105 in Urmia and 97 in Khorramabad). The data were processed using LISREL and SPSS software and statistical analysis technique was based on the structural equation modeling (SEM).
Results It was found that the original TAM constructs had a significant impact on the staffs' behavioral intention to adopt HIS in paraclinical departments. The results of this study indicated that cognitive instrumental processes (job relevance, output quality, result demonstrability, and perceived ease of use), except for result demonstrability, were significant predictors of intention to use, whereas the result revealed no significant relationship between social influence processes (subjective norm, voluntariness, and image) and the users' behavioral intention to use the system.
Conclusion The results confirmed that several factors in the TAM2 that were important in previous studies were not significant in paraclinical departments and in government-owned hospitals. The users' behavior factors are essential for successful usage of the system and should be considered. It provides valuable information for hospital system providers and policy makers in understanding the adoption challenges as well as practical guidance for the successful implementation of information systems in paraclinical departments.
Heilpflanzenwissen für die Prüfung
Authors: Schmid Eva C. 
Published: April 2018

SummaryPhytotherapeutika sind bei verschiedenen organischen Beschwerden eine weitverbreitete Therapieoption. Sie sind in vielen HP-Praxen üblich und nicht selten wird in der Heilpraktikerüberprüfung nach Grundwissen von Heilpflanzen und Phytotherapieoptionen gefragt.
Modern Techniques of Radiation Therapy in the Treatment of Brain Tumors and Tumors of the Skull Base
Authors: Diehl Christian , Combs Stephanie 
Published: April 2018

AbstractToday the choice of radiation oncology technique and treatment concept is highly individualized. Modern techniques enable the use of high local doses with significant sparing of normal tissue. This has significantly improved the therapeutic window. Molecular markers guide therapy decisions within the interdisciplinary context, for primary as well as secondary brain tumors. Skull base tumors benefit from highly precise radiation techniques; often, radiation therapy can be seen as a treatment alternative to surgery in this region.
Physiotherapy and Occupational Therapy in Acute Neurology
Authors: Seitz Rüdiger , Kolman Aschwin , Kraft-Kornwinkel Birgit , Robbers Sabine 
Published: April 2018

AbstractTherapy of neurological patients comprises, beyond medical treatment, the treatment of functional deficits which result from a neurological disease such as stroke. Physiotherapy aims at enabling bedridden neurological patients to become mobile again using training of movement and coordination. In cooperation with occupational therapists, patients are trained to become able to perform activities of daily living again. In addition, multimodal activating/assisting exercises are mandatory to counteract the deficit-related development of joint contractures. The rationale for these exercises are neurophysiological findings about postlesional cerebral plasticity. Moreover, parametric scales have been developed to assess neurological disturbances and to monitor their resolution in an observer-independent fashion. This allows communication across institutions and to assess the efficacy of physiotherapy and occupational therapy.
Hexaferrite multiferroics: from bulk to thick films
Authors: Koutzarova T , Ghelev Ch , Peneva P , Georgieva B , Kolev S , Vertruyen B , Closset R 
Published: April 2018

Abstract
We report studies of the structural and microstructural properties of Sr3Co2Fe24O41 in bulk form and as thick films. The precursor powders for the bulk form were prepared following the sol-gel auto-combustion method. The prepared pellets were synthesized at 1200 °C to produce Sr3Co2Fe24O41. The XRD spectra of the bulks showed the characteristic peaks corresponding to the Z-type hexaferrite structure as a main phase and second phases of CoFe2O4 and Sr3Fe2O7-x. The microstructure analysis of the cross-section of the bulk pellets revealed a hexagonal sheet structure. Large areas were observed of packages of hexagonal sheets where the separate hexagonal particles were ordered along the c axis. Sr3Co2Fe24O41 thick films were deposited from a suspension containing the Sr3Co2Fe24O41 powder. The microstructural analysis of the thick films showed that the particles had the perfect hexagonal shape typical for hexaferrites.
Computation and application of tissue-specific gene set weights
Authors: Frost H Robert 
Published: April 2018

Abstract

Motivation
Gene set testing, or pathway analysis, has become a critical tool for the analysis of high-dimensional genomic data. Although the function and activity of many genes and higher-level processes is tissue-specific, gene set testing is typically performed in a tissue agnostic fashion, which impacts statistical power and the interpretation and replication of results.

Results
To address this challenge, we have developed a bioinformatics approach to compute tissue-specific weights for individual gene sets using information on tissue-specific gene activity from the Human Protein Atlas (HPA). We used this approach to create a public repository of tissue-specific gene set weights for 37 different human tissue types from the HPA and all collections in the Molecular Signatures Database. To demonstrate the validity and utility of these weights, we explored three different applications: the functional characterization of human tissues, multi-tissue analysis for systemic diseases and tissue-specific gene set testing.

Availability and implementation
All data used in the reported analyses is publicly available. An R implementation of the method and tissue-specific weights for MSigDB gene set collections can be downloaded at http://www.dartmouth.edu/∼hrfrost/TissueSpecificGeneSets.
The Influence of Purchase Motivation on Perceived Preference Uniqueness and Assortment Size Choice
Authors: Whitley Sarah C , Trudel Remi , Kurt Didem 
Published: April 2018

Abstract
The present research examines how hedonic and utilitarian purchase motivations influence consumers’ perceptions of their product preferences and the resulting number of options they wish to consider when making a purchase. Across six studies, consumers choose to review larger assortments when their purchase motivation is hedonic rather than when their purchase motivation is utilitarian. This effect occurs because consumers with hedonic purchase motivations perceive their product preferences as highly unique compared to consumers with utilitarian purchase motivations. Higher perceived preference uniqueness increases the difficulty consumers anticipate in finding a preference-matching product, resulting in an expansion of the number of product alternatives to review. Further supporting the perceived preference uniqueness account, the documented effect is attenuated when product assortments are customized based on consumers’ personal preferences and when a social similarity priming task is employed. These findings provide additional evidence on the distinction between hedonic and utilitarian purchase motivations, their impact on perceived preference uniqueness, and their implications for consumer decision making via assortment size choice.
First United States Outbreak of Mycobacterium abscessus Hand and Foot Disease Among Children Associated With a Wading Pool
Authors: Carter Kris K , Lundgren Ingrid , Correll Sarah , Schmalz Tom , McCarter Tammie , Stroud Joshua , Bruesch Amanda , Hahn Christine G 
Published: April 2018

Abstract

Background
Mycobacterium abscessus, an emerging pathogen in healthcare settings, has rarely been associated with community outbreaks. During February–May 2013, Idaho public health officials and pediatric infectious disease physicians investigated an outbreak of M abscessus skin infections in children whose only common exposure was an indoor wading pool.

Methods
Healthcare providers and parents reported possible M abscessus cases. We used a standardized questionnaire to interview parents of affected children. Clinical specimens were submitted for mycobacterial examination. We conducted an environmental investigation of the pool. Microbial isolates from clinical and environmental samples were identified by sequencing polymerase chain reaction amplicons and underwent pulsed-field gel electrophoresis.

Results
Twelve cases were identified. Specimens from 4 of 7 children grew M abscessus or Mycobacterium abscessus/Mycobacterium chelonae . Ten (83%) of 12 children were female; median age was 3 years (range, 2 to 6 years); and all were immunocompetent. Pool maintenance did not fully comply with Idaho state rules governing pool operation. Mycobacterium abscessus/chelonae was isolated from pool equipment. Pulsed-field gel electrophoresis composite patterns were 87% similar between isolates from the pool ladder and 1 patient, and they were 90% similar between isolates from 2 patients. Environmental remediation included hyperchlorination, scrubbing and disinfection of pool surfaces, draining the pool, and replacement of worn pool materials.

Conclusions
Immunocompetent children acquired M abscessus cutaneous infection involving hands and feet after exposure to a wading pool. Environmental remediation and proper pool maintenance likely halted transmission. Medical and public health professionals’ collaboration effectively detected and controlled an outbreak caused by an emerging recreational waterborne pathogen.
Videoconferenced Telebehavioral Health Referral Process Adherence
Authors: Tebbs Jeffrey 
Published: April 2018

Abstract

Background
In 2015, the Army mandated 100% digital storage of telehealth consent forms (DA4700) in the Health Artifact and Image Management Solution (HAIMS) system, and a telebehavioral health (TBH) hub clinic set an aim to accomplish this by improving adherence to referral procedures essential to expanding patient access to videoconferenced (VC) behavioral health care.

Methods
The Knowledge-to-Action (KTA) planned action framework underpinned development of a two-phase, PDSA (Plan-Do-Study-Act) quality improvement project to increase the rates of TBH new intake consent form completeness and upload adherence. First, a provider education initiative addressed form uploads. Second, TBH consultants prepared (signed and sent) intake forms to referring sites for their patients to finalize during the initial VC encounter. A chart review of consecutive new intake encounters compared data extracted from CY2015 Q1 baseline records (n = 65) with data from CY2016 Q1 improvement period records (n = 40). A total of 352 forms were reviewed.

Results
Referrals (N = 118) that resulted in kept new VC TBH intake visits (n = 105), originated from three military behavioral health clinic referral sites. In CY2016 Q1, all DA4700 consent forms were uploaded to HAIMS. Telehealth treatment and medication consent form upload adherence increased from 94% and 68%, respectively, to 100% (p > 0.05). Form completeness increased from 36% to 95% (p < 0.001), and multiple linear regression analysis predicted an average 59% increase across the three referral sites (sr2 = 0.54).

Conclusion
Consultant preparation of telehealth new intake consent forms effectively improved form completeness and increased adherence to new intake referral processes essential to this hub clinic expanding patient access to TBH care.