bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saving Women's Lives From Cervical Cancer: Promoting a Cost-Effective Cervical Cancer Screening Tool in Rural Albania
Authors: Hylviu B. , Cekodhima G. , Rista M. , Shehu B. , Vandewiele M. , Huang Y. 
Published: September 2018

Background and context: The WHO has presented that more than 90% of deaths from cervical cancer happened in low and middle-income countries. Albania is one of them. Albania has a national cervical cancer screening program. However, the program is not well-promoted and the service is not always available at the primary public health care level. The situation worsens when it comes to rural areas. In 2016, to bridge the gap and achieve health equity the Albanian Center for Population and Development (ACPD) initiated a series of activities to promote the utilization of visual inspection with acetic acid (VIA) and cryotherapy for the first time as a pilot study in rural Albania. ACPD sees this as a health priority to strengthen the existing national screening program through advocacy with the Ministry of Health and Social Protection (MoHSP). Aim: To enable VIA and cryotherapy provision in rural Albania to expand cervical cancer screening by advocating for its integration into the national cervical cancer screening program. Strategy/Tactics: The strategy applies a client-centered and bottom-up approach. The changes are driven through four sections, namely: context understanding, providers' engagement, partnership strengthening, and sustainability development (Fig 1). Program/Policy process: Following the proposed strategy, four main approaches were developed. · Demand generation: ACPD promoted relevant cervical cancer prevention and treatment information as well as redressed misconceptions through developing education materials and carrying out education sessions. · Provide services in rural settings: ACPD engaged different health providers into the VIA and cryotherapy training and institutional protocol development. · Collaborate with key stakeholders: ACPD worked closely with stakeholders, such as civil society organizations (CSOs), media, and health facilities. · Provide medical evidence to affect national policy-making processes: ACPD provided strong evidence to support the integration of VIA and cryotherapy into the existing cervical cancer screening program. Outcomes: In line with aforementioned process, the project succeeded to establish an effective model improve national cervical cancer screening program. All achievements and outcomes are summarized in Table 1. What was learned: The proposed strategy enabled VIA and cryotherapy in rural Albania. From clients' perspectives, this cost-effective cervical cancer screening tool is well-accepted, and most women were thrilled by the idea that the precancerous lesions could be screened and eliminated at the same visit. It is evident that ACPD distributed this desired service in rural Albania through collaborating with key stakeholders, including media, CSOs and public health facilities. ACPD still works on integrating VIA and cryotherapy into the national cancer screening program to reduce cervical cancer deaths. [Figure: see text][Table: see text]
Telemedicine: Bridging the Gap Between Rural and Urban Oncologic Healthcare in Kenya
Authors: Mbunya S. , Asirwa C. , Felker D. 
Published: September 2018

Background: The AMPATH Consortium has served to greatly expand healthcare in western Kenya. Gaps and limitations in care still exist, especially in oncology care in rural areas. Telemedicine provides a lower cost, practical method to maximize physician resources and limit cost and stress to families with socioeconomic limitations in rural Kenya. The following paper seeks to discuss the importance of developing a telemedicine model in western Kenya and the many advantages telemedicine can bring, as well as discuss the telemedicine model being developed by AMPATH Oncology. Aim: Integrate paper-based medical records into the AMPATH AIDS EMR; Identify sustainable telemedicine tools to integrate into the EMR; Establish networking in rural clinics; Budget in IT personnel at each clinic to assist in patient setup with central site; use solar as primary power source for devices to aid in power issues. Only 45% of Kenyans have access to power; Use cellular networks for communication; Maximize time allocated for physicians to see patients; Decrease travel time to clinics as only 32% of Kenyans live in urban environments. Methods: Cost analysis of remote clinic locations and associated costs; Clinic budget estimate for networking and telemedicine support position; Cost summary and savings Results: Estimated costs for the operations budget for the 17 rural outreach clinics include the costs of hardware, solar networking setup, and internet at a total $3400/wk. This will decrease after the first year to $1700 for maintenance costs of equipment. Personnel consists of 1 local person to support the system and will be a weekly cost of $1870. Lost time for physicians due to road travel totals ∼100 hours weekly. Estimated salaries for an oncologist at $30/h leads to a cost of $3007/wk in lost productivity. It should be noted that lodging and per diem expenses are not included in the estimated expenses that total $6114/wk. By doing telemedicine at the rural clinics in an ideal 48 workable week situation. The savings of $528,000 is a clear evidence that this is financially feasible solely based on travel savings over 5 years. For this reason, the actual savings is ∼$264,000 and still makes a strong argument for this being the right move. Conclusion: Telemedicine is a viable and necessary resource for developing oncologic care in rural Kenya. We believe that telemedicine represents a natural evolution in healthcare in Kenya to support its rural population. Telemedicine helps maximize the limited physician resources and allows them to reach a larger audience without tying up their time in lengthy commutes. Last, telemedicine should assist patients to overcome the barriers of cost and time that limit their treatment. Future challenges and gains will be made with the evolution of the newly formed national health insurance system. Gaining support and reimbursement from telemedicine visits will be crucial to ensuring the success of telemedicine.
A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex
Authors: Vaid Samir , Camp J. Gray , Hersemann Lena , Eugster Oegema Christina , Heninger Anne-Kristin , Winkler Sylke , Brandl Holger , Sarov Mihail , Treutlein Barbara , Huttner Wieland B. , Namba Takashi 
Published: September 2018

ABSTRACT
A specific subpopulation of neural progenitor cells, the basal radial glial cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of the mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that the developing mouse medial neocortex (medNcx), in contrast to the canonically studied lateral neocortex (latNcx), exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. Unlike bRGCs in developing mouse latNcx, the bRGCs in medNcx exhibit human bRGC-like gene expression, including expression of Hopx, a human bRGC marker. Disruption of Hopx expression in mouse embryonic medNcx and forced Hopx expression in mouse embryonic latNcx demonstrate that Hopx is required and sufficient, respectively, for bRGC abundance as found in the developing gyrencephalic neocortex. Taken together, our data identify a novel bRGC subpopulation in developing mouse medNcx that is highly related to bRGCs of developing gyrencephalic neocortex.
Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies
Authors: Parada-Kusz Margarita , Penaranda Cristina , Hagedorn Elliott J. , Clatworthy Anne , Nair Anil V. , Henninger Jonathan E. , Ernst Christoph , Li Brian , Riquelme Raquel , Jijon Humberto , Villablanca Eduardo J. , Zon Leonard I. , Hung Deborah , Allende Miguel L. 
Published: September 2018

ABSTRACT
Xenografts of the hematopoietic system are extremely useful as disease models and for translational research. Zebrafish xenografts have been widely used to monitor blood cancer cell dissemination and homing due to the optical clarity of embryos and larvae, which allow unrestricted in vivo visualization of migratory events. Here, we have developed a xenotransplantation technique that transiently generates hundreds of hematopoietic tissue chimeric embryos by transplanting murine bone marrow cells into zebrafish blastulae. In contrast to previous methods, this procedure allows mammalian cell integration into the fish developmental hematopoietic program, which results in chimeric animals containing distinct phenotypes of murine blood cells in both circulation and the hematopoietic niche. Murine cells in chimeric animals express antigens related to (i) hematopoietic stem and progenitor cells, (ii) active cell proliferation and (iii) myeloid cell lineages. We verified the utility of this method by monitoring zebrafish chimeras during development using in vivo non-invasive imaging to show novel murine cell behaviors, such as homing to primitive and definitive hematopoietic tissues, dynamic hematopoietic cell and hematopoietic niche interactions, and response to bacterial infection. Overall, transplantation into the zebrafish blastula provides a useful method that simplifies the generation of numerous chimeric animals and expands the range of murine cell behaviors that can be studied in zebrafish chimeras. In addition, integration of murine cells into the host hematopoietic system during development suggests highly conserved molecular mechanisms of hematopoiesis between zebrafish and mammals.
This article has an associated First Person interview with the first author of the paper.
Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse
Authors: Lee Kevin K. L. , Peskett Emma , Quinn Charlotte M. , Aiello Rosanna , Adeeva Liliya , Moulding Dale A. , Stanier Philip , Pauws Erwin 
Published: September 2018

ABSTRACT
FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the FGFR2 gene are causative of multiple forms of syndromic craniosynostosis, including Crouzon syndrome. Paradoxically, mouse studies have shown that the activation (Fgfr2cC342Y; a mouse model for human Crouzon syndrome), as well as the removal (Fgfr2cnull), of the FGFR2c isoform can drive suture abolishment. This study aims to address the downstream effects of pathogenic FGFR2c signalling by studying the effects of Fgfr2c overexpression. Conditional overexpression of Fgfr2c (R26RFgfr2c;βact) results in craniofacial hypoplasia as well as microtia and cleft palate. Contrary to Fgfr2cnull and Fgfr2cC342Y, Fgfr2c overexpression is insufficient to drive onset of craniosynostosis. Examination of the MAPK/ERK pathway in the embryonic sutures of Fgfr2cC342Y and R26RFgfr2c;βact mice reveals that both mutants have increased pERK expression. The contrasting phenotypes between Fgfr2cC342Y and R26RFgfr2c;βact mice prompted us to assess the impact of the Fgfr2c overexpression allele on the Crouzon mouse (Fgfr2cC342Y), in particular its effects on the coronal suture. Our results demonstrate that Fgfr2c overexpression is sufficient to partially rescue craniosynostosis through increased proliferation and reduced osteogenic activity in E18.5 Fgfr2cC342Y embryos. This study demonstrates the intricate balance of FGF signalling required for correct calvarial bone and suture morphogenesis, and that increasing the expression of the wild-type FGFR2c isoform could be a way to prevent or delay craniosynostosis progression.
EL GERENTE DESCARTABLE: UN DILEMA ENTRE LA OPTIMIZACIÓN DE LA PRODUCTIVIDAD Y LA MINIMIZACIÓN DEL BIEN-ESTAR SOCIAL
Authors: Kasznar Istvan Karoy 
Published: September 2018

Este artículo caracteriza y muestra una importante alternativa de contratación de trabajadores especializados, de buena formación superior, normalmente universitária, que se ven transformados envendedores, hazen parte de la fuerza de ventas y promueven en La realidad los resultados económicos y financieros empresariales que se buscan en políticas de Marketing. El autor muestra que motivadas por la busca de resultados inmediatos, numerosas instituciones financieras han optado por la contratación de una mano de obra que es predominantemente descartable. Esto crea sequelas en las empresas, entre ellas la falta de fidelidad. Y en los sujetos descartados, puede producir efectos como desmotivación,depresión, y falta de cooperativismo con la empresa originalmente contratante.
Receiving antenna electrodynamic model in terms of waveguide representation of HF field
Authors: Хахинов Виталий , Khakhinov Vitaliy 
Published: September 2018

The receiving antenna is an important part of a radio channel that requires electrodynamic approach in mathematical simulation of its characteristics. Since the invention of radio, and due to further theoretical studies of radio signal transmission, the following situation has arisen: researchers’ attention to receiving antennas is inversely proportional to the factor by which their number exceeds the number of transmitting antennas. We address the problem of building a receiving antenna electrodynamic model in terms of a waveguide representation of HF field. Structurally, the antenna is considered as metal wires of a finite length and arbi-trary configuration. Current distribution in antenna is calculated using the long-line theory and normal-mode approach. The mathematical representation of the receiving antenna electrodynamic model is calculation expressions for receiving coefficients of normal modes. They reflect the effects of receiving antenna characteristics, including its directional pattern, on ef-fectiveness of the incident HF field energy conversion into the energy of the driven current waves and final distribution of net current in antenna. These expressions are used to derive the expression to calculate the effective length of the receiving antenna.
The obtained mathematical expressions of the re-ceiving antenna electrodynamic model do not contradict the principle of antenna reciprocity.
We present calculation formulas for the receiving coefficients and excitation of the isotropic antenna electromagnetic model.
Learning by doing: ‘Working out’ in craft research
Authors: Gill Kathryn 
Published: September 2018

Abstract
As part of a conservation and access project, the author was asked to replicate a set of rare thread-wrapped coat buttons that proved to be of a previously undocumented form. Using knowledge of the technologies of historic textiles and upholstery and extensive experience of image-based documentation, the thread-wrapping of the buttons was reconstructed through a process characterized as ‘learning by doing’. This involved: studying the surviving buttons and button fragments; working with large-scale images of the buttons to analyse possible wrapping sequences; making large-scale models to study the effects of thread-wrapping in practice; and finally, having worked-out (literally and metaphorically) the wrapping techniques, making appropriately sized buttons for a replica of a coat dated circa 1700. This paper demonstrates how knowledge creation (replicating the button-wrapping technique and the thread-wrapped buttons) was achieved by a dialectical process of manual discovery, comparison with published sources, and evaluation and adjustment ‘in the hand’.
Book Reviews
Authors: Baines Elizabeth , Devane Emily 
Published: September 2018

Abstract

Conradology: A Celebration of the Work of Joseph Conrad, Becky Harrison and Magda Raczyńska (eds) (2017)
Manchester: Comma Press, 209 pp.,
ISBN 978-1-91097-433-9, p/bk, £9.99
Four voices: Recent short story collections

The Missing Girl, Jacqueline Doyle (2017)
New York: Black Lawrence Press, 31 pp.,
ISBN 978-1-62557-983-6, p/bk, $8.95

The Liars’ Asylum, Jacob M. Appel (2017)
New York: Black Lawrence Press, 168 pp.,
ISBN 978-1-62557-975-1, p/bk, $16.95

Mothers, Chris Power (2018)
London: Faber & Faber, 304 pp.,
ISBN 978-0-57133-968-6, h/bk, £10

Dazzling the Gods, Tom Vowler (2018)
London: Unbound, 240 pp.,
ISBN 978-1-78352-398-6, p/bk, £8.99
Segmentivity, narrativity and the short form: The Twitter stories of Moody, Egan and Mitchell
Authors: D’hoker Elke 
Published: September 2018

Abstract
This article seeks to complement existing media-based approaches to Twitter fiction with a genre-based approach that considers it in the context of the genre and the tradition of the short story. After a brief introductory overview of Twitter fiction, I discuss three Twitter stories, written by established authors: Rick Moody’s ‘Some Contemporary Characters’ (2009), Jennifer Egan’s ‘Black Box’ (2012) and David Mitchell’s ‘The Right Sort’ (2014a). In a close textual analysis of these stories, I trace the impact of the Twitter format on the style, plot, themes and narrative techniques of these short stories. More particularly, I show how each of these works combines poetic and narrative techniques, or what DuPlessis has called ‘segmentivity’ and ‘narrativity’, in a different way. Finally, the conclusion considers the characteristics of these Twitter stories in the light of the tradition and the genre of the modern short story more in general.
‘Instant Junk’: The Thing (1982), the box-office gross factor, and reviews from another world
Authors: Barnett Vincent L. 
Published: September 2018

Abstract
This article provides a detailed examination of the production budget and then the opening, the ongoing and the total US and international box-office revenue of John Carpenter’s very influential 1982 terror film The Thing. It then uses this analysis to understand in more depth why the film was a commercial failure on its first release in relation to various hypothesized reasons for failure that have been proposed in the literature, and in relation to the commercial performances of Carpenter’s other genre films such as Halloween, The Fog and Escape from New York. It also examines some of the methods of financing used on Carpenter’s films and the impact of the commercial failure of The Thing on US horror films more widely. It argues, controversially, that of all the factors that have been considered, there was one main factor that accounted for the initial box-office failure of The Thing (very negative reviews); the other factors that have been suggested were either minor additional elements, or are seen not to apply to the film when they are considered in more detail.
Aplicação da estatística multivariada no diagnóstico do processo de salinização em açudes do semiárido nordestino, Ceará/Brasil
Authors: Siqueira Jose Batista , Lima Sanmy Silveira 
Published: September 2018

No estado do Ceará há diversos açudes utilizados para mitigar os impactos das secas para as populações. Entretanto as águas desses açudes estão sendo afetadas por diferentes processos de salinização, afetando sua qualidade e conseqüente uso. Este trabalho refere-se ao estudo dos açudes Trici e Favelas, sub-bacia do Alto Jaguaribe/CE, localizada a Sudeste do Município de Tauá, visando estabelecer um diagnóstico do processo de salinização. Portanto para estabelecer um diagnóstico da causa ou causas da salinização nas bacias hidrográficas dos açudes Favelas e Trici no estado do Ceará, foram geradas informações para as duas bacias. Dentre elas destacam-se as amostragens de águas, nas quais foram abordadas as variáveis temperatura da água (TH2O), condutividade elétrica (CE µS/cm), pH (concentração hidrogeniônica do meio), potencial de oxidação e redução (ORP), sólidos totais dissolvidos (TDS). Para analisar os dos obtidos foram aplicadas estatística univariada e as técnicas estatísticas multivariadas da análise de componentes principais (PCA) e análise discriminante, com auxilio do software PAST 3. Considerando os resultados estatísticos e da análise estatística multivariada das variáveis TH2O, CE µS/cm, pH, ORP e TDS, tanto no na bacia do açude Favelas como do Trici, verifica-se que elas apresentam comportamentos diferentes. Portanto justificando, a influência dos diferentes processos de salinização que estão ocorrendo nas duas bacias.
Fostering transformational teacher agency in Finnish teacher education
Authors: Matikainen Minni , Männistö Perttui , Fornaciari Aleksi 
Published: September 2018

In this article, we studied how well teacher education in Finland is able to answer the changing needs of the contemporary world. More precisely, we focussed on the question of how well an alternative teacher education model guides teacher students’ agency towards a transformational view of the teaching profession, making it possible for schools to enable social change. This question was studied in the framework of critical social pedagogy. The data for this article was collected ethnographically by observing meetings in the Critical Integrative Teacher Education (CITE) programme at the University of Jyväskylä in 2015–2017.The analysis is based on a theoretical background in which we outline two different discourses on the concept of teachers’ agency. The first promotes schools’ role in conservation; teachers are expected to educate obedient and uncritical citizens to maintain steady economic growth. The second discourse is defined as critical and emancipatory, where the education pursues transformation in students’ underlying attitudes and a deeper understanding of education and society.The results showed that the CITE model fosters teacher students’ critical self-reflection and understanding of group phenomena considering education. The students’ ability to understand schools in a social context also develops. However, CITE seems to struggle in transforming the students’ thinking and understanding into actions. According to the data, feelings of inability, cynicism and a lacklustre ability to understand concretely how teachers can have an impact on society through their profession prevent a more complete transformation in the students’ everyday modes of action. A stronger community perspective, collaboration with institutions outside teacher education, the enabling of group-oriented action and the provision of real-life experiences regarding the transformation could better help to develop future teachers’ agency towards transformational views.
Manisnya Kopi di Era Liberal: Perkebunan Kopi Afdeling Malang, 1870-1930
Authors: Afgani Rixvan , Husain Sarkawi B. 
Published: September 2018

This article discusses about the coffee plantation at Afdeling Malang in 1870-1930 with the dynamics of emergence on the agrarian laws during liberal period. This research uses historical method. It shows that the journey of coffee plantation during that time had been fluctuated. To achieve the expected production, foreign private investora were involved to establish new plantations or branch of the plantation (with the same brand). They did the nusery on coffee plants, the use of various types such as Robusta, Arabica/Java and Liberia. Towards 1898 until 1910s, bladziektedisease suffered coffee plants. The coffee production was decreased, it needed the another coffee variety that could more resist from disease. The malaisecrisis in 1930 had influenced coffee plantation, due to the number of coffee plantations were decrease, it affected the production that was lower compare than before.