bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Evaluation of 2-aminothiazole Hybrid as Antimalarial and Antitrypanosomal Agents: Design and Synthesis
Authors: Jadav Surender S. , Badavath Vishnu N. , Ganesan Ramesh , Ganta Narayana M. , Besson Dominique , Jayaprakash Venkatesan 
Published: October 2018

Background:
A series of 2-aminothiazole schiff’s bases (1-24) were synthesized and
screened against a few neglected tropical disorders (NTDs). Compounds 12 and 14 were found to
have antitrypanosidal activity, whereas compound 14 was found to be more effective than standard
benznidazole. The antiplasmodial assay provided three specific and effective compounds (9, 12 and
24) than standard chloroquine. Compound (21) inhibited Leishmania infantum, almost similar to
Miltefosine.

Methods:
All the compounds were subjected to cytotoxicity assay and none of the compounds
were found to be cytotoxicity. Molecular docking simulations revealed that four compounds (1, 9,
12 and 21) were found to similarly occupy the hydrophobic active site of trans-2-enoyl acyl carrier
protein reductase of P. falciparum (PfENR) as triclosan and outcomes were closely related to their
anti-malarial potencies.

Results and Conclusion:
The screening results against T. cruzi, T. brucei, L. donovani, L. infantum,
P. falciferum and cytotoxicity assays provided a few significant to most potent compounds;
two variant class of NTDs.
Pengembangan multimedia pembelajaran untuk mengembangkan aspek kognitif anak
Authors: Pratiwi Henny Riska , Ismaniati Christina 
Published: October 2018

Penelitian ini bertujuan: (1) menghasilkan produk multimedia pembelajaran untuk mengembangkan aspek kognitif pada materi mengenal bilangan anak Palm Kids School Yogyakarta, dan (2) mengetahui tingkat kelayakan produk yang dikembangkan. Penelitian ini merupakan penelitian dan pengembangan yang mengacu pada langkah-langkah desain pengembangan Allesi & Trollip, yang dikelompokkan atas tiga prosedur pengembangan, meliputi: (a) planning, (b) design, dan (c) development yang dilengkapi dengan komponen atribut mencakup standards, ongoing evaluation, dan project management. Penelitian ini menghasilkan produk multimedia pembelajaran yang memenuhi kriteria dan dinyatakan layak sebagai media pembelajaran. Skor penilaian kelayakan produk melalui uji alpha pada ahli materi adalah 3,4 (layak) dan pada ahli media adalah 3,36 (layak). Uji beta menunjukkan skor hasil penilaian guru kelas K1 sebesar 3,7 (sangat layak). Kelayakan produk multimedia pembelajaran pada peningkatan perkembangan kognitif didukung oleh peningkatan perolehan skor hasil belajar kognitif anak K1 yang diketahui dari hasil pretes dan postes anak adalah sebesar 8,7.Kata kunci: multimedia pembelajaran, kognitif anak DEVELOPING TEACHING MULTIMEDIA TO IMPROVE THE COGNITIVE ASPECTS OF THE CHILDRENAbstractThis study aims to: (1) produce learning multimedia improve the cognitive aspects of the children of Palm Kids School Yogyakarta in understanding numbers, and (2) determine the feasibility level of the developed product. This research was research and development refering to the steps of developmental design proposed by Allesi and Trollip. The design was classified into three developmental procedures including: (a) planning, (b) design, and (c) development, completed with attributes of component including standards, ongoing evaluation, and project management. This study produced teaching multimedia which meet the criteria and the product is declared feasible as teaching media based on the score of product’s feasibility assessment through alpha test by material experts which is at 3.4 (feasible) and by media expert at 3.36 (feasible). Furthermore, the beta test conducted by teacher of K1 class showed the score of 3.7 (highly feasible). The product’s feasibility assessment of the teaching multimedia in improving the development of cognitive aspects was supported by the score of cognitive learning outcomes of the children in K1 class was observed by pre-test and post-test showing 8.7.Keywords: teaching multimedia, children’s cognitive
Evaluasi bahan ajar Bahasa Prancis Le Mag sebagai bahan pembelajaran mandiri siswa Sekolah Menengah Atas
Authors: Sari Kartika Permata 
Published: October 2018

Tujuan penelitian ini adalah mengetahui kualitas bahan ajar Bahasa Prancis Le Mag yang digunakan oleh siswa sebagai sumber belajar dalam proses pembelajaran. Kriteria yang digunakan untuk mengevaluasi bahan ajar ini adalah kriteria dari aspek desain instruksional, aspek desain pesan dan aspek karakteristik siswa.Penelitian ini merupakan penelitian evaluasi dengan pendekatan kuantitatif. Model evaluasi yang digunakan adalah model evaluasi formatif oleh Dick and Carey yang dilakukan dengan dua tahap, yaitu evaluasi one to one by expert dan evaluasi one to one by student. Instrumen yang digunakan adalah lembar penilaian bahan ajar. Hasil penelitian menunjukkan bahwa bahan ajar Le Mag sebagai bahan ajar bahasa Prancis memiliki kualitas baik untuk digunakan sebagai bahan ajar mandiri siswa SMA dalam proses pembelajaran. Kualitas tersebut berdasarkan penilaian dari ahli materi, media dan siswa yang menghasilkan data sebagai berikut: (1) Oleh ahli materi memperoleh rata-rata 4,1 dalam kategori sangat baik. (2) Oleh ahli media memperoleh rata-rata 4,57 dalam kategori sangat baik. (3) Oleh siswa memperoleh rata-rata 3,2 dalam katego baik.Kata kunci: evaluasi, bahan ajar bahasa Prancis, bahan ajar mandiri AN EVALUATION OF FRENCH LANGUAGE MATERIALS AS SELF-DIRECTED LEARNING MATERIALS FOR HIGH SCHOOL STUDENTAbstractThe purpose of this study is to know the quality of French Le Mag teaching materials used by students as learning resources in the learning process. This study is an evaluation research using quantitative method approach. The evaluation model used in this research was a formative evaluation model by Dick and Carey which was conducted in two stages, one-to-one evaluation by expert and one to one evaluation by student. The results showed that learning material of French Le Mag was suitable to be used as self learning material of high school student. That results were based on the assessment of material experts, media expert and students which obtained the data: (1) By the material expert obtain an average of 4.10 in the criteria of very good. (2) By the media expert obtains an average of 4.57 in criteria very good. (3) By students earning an average of 3.2 in criteria good.Keywords: Evaluation, French Learning Materials, Self-Directed Learning Materials
Pengembangan Metode Identifikasi Kerusakan DNA Spermatozoa Ternak
Authors: Prabowo Teguh Ari , Arifiantini R. Iis , Sajuthi Dondin , Saefullah Uus 
Published: October 2018

The success of artificial insemination is very much determined by the quality of spermatozoa. The detection or identification of damaged chromatin of spermatozoa DNA is very important to forsee the adverse clinical outcome. However, the method of identification is still depended on expensive imported kits. Therefore, the objective of this research was to developed an identification kit to determine the quality of livestock spermatozoa DNA chromatin.This study consist of three step. Step 1) Determination of low melting point agarose (LMP-agarose) concentration which is 0,6%, 0,7% and 0,8%. 2) Comparison of three lysis solution (LS) which is LS I (0.4M Tris, 0.8M DTT, 1% SDS, pH 7.5), LS II (0.4M Tris,2 M NaCl, 1% SDS , pH 7.5), and LS III (0.4M Tris-HCl, 2M NaCl, 1% SDS 0,05 M EDTA, pH 7.5). 3) Comparison different staining which is Eosin yellow and Methylene blue. The results showed that 0.6% LMP-agarose demonstrated the best concentration to “trapped the spermatozoa” compared for sheep and goats. whereas the three concentration of spermatozoa cows can not be used to trap spermatozoa cow. The best formulation to lysis the membrane was LS III (0.4M Tris -HCl, 2M NaCl, 1% SDS 0,05 M EDTA). The best staining was eosin yellow and methylene blue with 2:1 ratio.
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of “A+” Subtypes of Ketosis-Prone Diabetes
Authors: Mulukutla Surya N. , Acevedo-Calado Maria , Hampe Christiane S. , Pietropaolo Massimo , Balasubramanyam Ashok 
Published: October 2018

OBJECTIVE
Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), &gt;60% of adults lack three classic islet autoantibodies—IA-2, GAD65, and ZnT8 Abs—associated with type 1 diabetes. We aimed to determine whether apparently autoantibody-negative (“A−”) KPD patients possess occult IA-2 Ab directed against full-length IA-2 (IA-2FL) or its extracellular domain (IA-2EC).

RESEARCH DESIGN AND METHODS
We developed an assay that targets IA-2FL and IA-2EC and used it to analyze 288 subjects with A− KPD.

RESULTS
Ten A− KPD patients were positive for IA-2EC Ab (3.5%), and three were also positive for IA-2FL Ab (1.0%), similar to frequencies in type 1 and type 2 diabetes.

CONCLUSIONS
Measurement of IA-2FL Ab and IA-2EC Ab improves the accuracy of the Aβ classification of KPD patients.
Sinopsis de Ipomoea L. y Merremia Dennst. Ex Endl. (Convolvulaceae) en el norte del Perú (Lambayeque y territorios adyacentes). Synopsis of Ipomoea L. and Merremia Dennst. ex Endl. (Convolvulaceae) in the North of Peru (Lambayeque and surrounding areas)
Authors: Alarcón-Bravo Luciana , Torres-Reaño Gabriela , Austin Daniel F. , Rojas-Idrogo Consuelo , Delgado-Paredes Guillermo E. 
Published: October 2018

Español. El objetivo principal de este trabajo es identificar y comentar los registros anteriores y nuevos de los géneros Ipomoea y Merremia en el departamento de Lambayeque (Perú) y zonas circundantes. Se describen 18 especies de Ipomoea y 3 especies de Merremia: Ipomoea alba, I. asarifolia, I. hederifolia, I. indica, I. nil e I. wrightii. I. aristolochiifolia, I. batatas, I. cairica, I. carnea, I. incarnata, I. parasitica, I. piurensis, I. purpurea, I. tiliacea, Merremia aegyptia, M. quinquefolia y M. umbellata son nuevos registros para la flora de Lambayeque. Incluso Ipomoea amnicola, I. dumetorum e I. quamoclit se reportan como nuevos registros en el departamento adyacente de Cajamarca. Se presentan claves para identificar las especies y los grupos intergenéricos. La distribución de cada especie es también presentada para mostrar su biogeografía.English. The main of this paper is to identifie and to comment previous and new records of Ipomoea and Merremia in Lambayeque Department (Peru) and surrounding areas. 18 species of Ipomoea and 3 species of Merremia are reported: Ipomoea alba, I. asarifolia, I. hederifolia, I. indica, I. nil e I. wrightii. I. aristolochiifolia, I. batatas, I. cairica, I. carnea, I. incarnata, I. tiliacea, I. parasitica, I. piurensis, I. purpurea, Merremia aegyptia, M. quinquefolia y M. umbellata are new records for the Lambayeque flora. Even, I. amnicola, I. dumetorum and I. quamoclit were found as new records in the adjacent Cajamarca Department. Keys are provided for to identifie species and infrageneric groups. Distribution of each species is also presented in order to show their biogeography
Co-optimization of oil recovery and CO2 storage for cyclic CO2 flooding in ultralow permeability reservoirs
Authors: Sun Lili , Hao Xining , Dou Hongen , Daniel Adenutsi Caspar , Li Zhiping , Zhang Yunjun 
Published: October 2018

Cyclic CO2 flooding is an efficient method to enhance oil recovery in ultralow permeability reservoirs. As the demand for low carbon economy development, co-optimization of CO2 storage and utilization should be considered. In this research, initially a comprehensive optimization method was proposed, which co-optimize oil recovery and CO2 storage by different weighting factors. Then, a series of core flooding experiments were performed using the core samples collected from Changqing oilfield, which is a ultralow permeability reservoir with heterogeneity and micro-cracks, CO2 injection parameters of slug size and Injection-Soaking Time Ratio (ISR) were optimized. The results revealed that the optimal injection parameters changed for different optimization objectives. In the case where equal important to oil recovery and CO2 storage were considered, the optimum CO2 injection parameters in the ultralow permeability reservoirs were 0.03PV for slug size and 1:1 for ISR. Comparing the method of oil recovery optimization (ω
1 = 1) to co-optimization of oil recovery and CO2 storage (ω
1 = ω
2 = 0.5), oil recovery was reduced by 8.93%, CO2 storage was significantly increased by 25.85%. The results provide an insight into parameter optimization of CO2 enhanced oil recovery design.
Potensi Penggunaan Dua Spesies Agave untuk Pembuatan Pulp dan Kertas
Authors: Jamil Arini Hidayati , Tjahjono Heronimus Judi , Parnidi Parnidi , Marjani Marjani 
Published: October 2018

Potential of Two Agave Species for Pulp and Paper MakingAbstractBoth of Agave sisalana and A. cantala are the most favorite agave species for fiber producer plant in Indonesia. Nevertheless, research study for using fiber of A. sisalana and A. cantala for pulp and paper purpose is hard to find. This study aims to observe the characteristics of A. sisalana and A. cantala fibers as a raw material of pulp including fiber morphology, chemical components, pulp characteristics, optical and physical properties of the handsheets. The observation of all characters was based on Indonesian National Standard (SNI). The pulping method used both of soda process with 18% active alkali and kraft process with 18% active alkali and 25% sulfidity. The result of the study for the handsheets from A. sisalana and A. cantala fibers shows that the brightness, dirt, and tear index were fulfilled to SNI standard for NBKP while the tensile index and burst index just fulfilled to SNI standard for LBKP. The handsheet of A. sisalana fiber has a higher tear index, tensile index, and burst index than the A. cantala ones. Soda pulping of both agave species resulting higher pulp yield, cellulose polymerization degrees and physical properties than kraft pulping.Keywords : Agave sisalana, A. cantala, characteristics of the fiber, pulp AbstrakAgave sisalana dan A. cantala merupakan dua spesies agave yang paling banyak dibudidayakan di Indonesia sebagai tanaman penghasil serat alam. Namun penelitian mengenai fungsi serat A. sisalana dan A. cantala sebagai bahan baku pulp dan kertas masih sulit ditemukan. Tujuan dari penelitian ini adalah mempelajari karakteristik serat A. sisalana dan A. cantala sebagai bahan baku pulp yang meliputi morfologi serat, komposisi komponen kimia, karakeristik pulp, sifat optik dan fisik lembaran pulp yang dihasilkan. Pengamatan seluruh karakter dilakukan berdasarkan Standar Nasional Indonesia. Pemasakan menggunakan metode soda dengan alkali aktif 18% dan kraft dengan alkali aktif 18% dan sulfiditas 25%. Hasil pengamatan pada lembaran pulp yang dihasilkan dari serat A. sisalana dan A. cantala menunjukkan bahwa derajat cerah, noda, dan kekuatan sobek memenuhi Standar Nasional Indonesia (SNI) Pulp Kraft Putih Kayujarum (NBKP) sementara kekuatan tarik dan kekuatan retak memenuhi SNI Pulp Krat Putih Kayudaun (LBKP). Lembaran pulp A. sisalana memiliki kekuatan sobek, tarik, dan retak lebih tinggi dibanding lembaran pulp A. cantala. Metode pemasakan soda pada serat kedua spesies agave tersebut menghasilkan rendemen pulp, derajat polimerisasi selulosa, dan kekuatan fisik lebih baik dibanding metode kraft.Kata kunci : Agave sisalana, A. cantala, karakteristik serat, pulp
Alt Ekstremite Uzatma Osteotomilerinin Klinik Sonuçları
Authors: ÖZER Devrim , ARİKAN Yavuz 
Published: October 2018

Amaç : Çalışmamızda; alt eksremite
kısalığı olan hastalarda, monolateral ve halkalı eksternal fiksatör
kullanılarak, distraksion osteogenezi tekniği ile yaptığımız uzatma
olgularımızın sonuçlarını değerlendirmeyi amaçladık.Hastalar ve Yöntem: Çalışmamızda; 12 hastanın 16 alt
ekstremitesinde distraksion osteogenezi tekniği ile yapılan alt eksremite
uzatma osteotomilerinin sonuçlarını açıklamaya çalıştık. Hastaların 7'i kadın,
5'i erkek di. Ortalama yaş 11,8(4-26) dı. Hastaların 4'ünin femuru, 4'ünün
tibiası ve 4 hastanın da hem femuru hem de tibiası uzatılmıştır. 15 hastanın
uzatmasında monolateral eksternal fiksatör(orthofix), bir hastanın
uzatmasında İlizarov'un halkalı
eksternal fiksatörü kullanıldı. Bulgular: Ortalama uzama miktarı 3,5 cm(2-7),
uzatma öncesi bekleme süresi ortalama 13,2 gün(9-20), iyileşme indeksi ortalama
52(31-90), kazanılan uzunluğun uzatılan kemik segmentine oranı ortalama
%13,6(%5-%19), fiksatörlerin kalış süresi ortalama 182 gün(140-270)dür. Yapılan
16 alt ekstremite uzatma isleminde 20
komplikasyon görüldü. En sık görülen komplikasyon (9 hastada) Açılanmadır.

Sonuç: İlizarov'un uzatma prensiplerine
bağlı olarak yapılan uzatmalarda ,uzatmalar başarılı şekilde gerçekleşmektedir;
ancak komplikasyon sayısının fazla olabileceği ve operasyon deneyimin önemli
olduğu unutulmamalıdır.
Pembuatan Bioetanol Berbahan Baku Kertas Bekas menggunakan Metode Hidrolisis Asam dan Fermentasi
Authors: Ramayanti Cindi , Giasmara Ketty R. 
Published: October 2018

The enormous global daily consumption of liquid fuels is of the order of 80 million barrels/day (equivalent of 12.7 million m3/day). The sugar cane area required to produce the same volume of ethanol about 700 million hectares, assuming a yield of 6.5 m3/ha/year of ethanol. This study focus to use the second generation feedstock for bioethanol production. Waste papers have cellulose biomass in high percentage so that can be used as potential alternative biomass feedstock to convert bioethanol. Alkaline delignification was conducted by sodium hydroxide (NaOH) and then hydrolyzed using sulfuric acid (H2SO4) diluted with various concentrations (2%, 2.5%, 3%, 3.5%, 4%, and 5% (v/v) and then fermentation was carried out by Saccharomyces cereviciae with the variation fermentation time (4 days, 5 days, 6 days, 7 days, and 8 days). Ethanol will be produced after separated using evaporation process. The results for the paper inked with the highest ethanol content of 6,12 % (v/v) was obtained at a concentration of 4% sulfuric acid (v / v) and 7 days fermentation time. While the paper without ink obtained the highest ethanol content of 8,13 % (v / v) sulfuric acid at a concentration of 4% (v/v) and 7 days fermentation time
Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018
Authors: Evered L. , Silbert B. , Knopman D.S. , Scott D.A. , DeKosky S.T. , Rasmussen L.S. , Oh E.S. , Crosby G. , Berger M. , Eckenhoff R.G. ,   The Nomenclature Consensus Working Group
Published: October 2018

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. Other than the inclusion of non-surgical control groups to calculate postoperative cognitive dysfunction, research into these cognitive changes in the perioperative period has been undertaken in isolation from cognitive studies in the general population. The aim of this work is to develop similar terminology to that used in cognitive classifications of the general population for use in investigations of cognitive changes after anaesthesia and surgery. A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions. Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that ‘perioperative neurocognitive disorders’ be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period. This includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event ( postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure ( delayed neurocognitive recovery) and up to 12 months ( postoperative neurocognitive disorder).
Una nueva visión del proceso comunicativo: la teoría del Enfoque (Framing)
Authors: Giménez Armentia Pilar 
Published: October 2018

A lo largo de la historia de la comunicación, un tema que ha ocupado el estudio de numerosos investigadores ha sido la relación entre verdad e información. El dominio de la corriente objetivista durante la década de los 60 impuso un pensamiento fáctico del proceso comunicativo. Con su máxima “los hechos son sagrados, las opiniones libres” el objetivismo se aseguraba la no intromisión del sujeto en la información. La noticia se consagraba así como un fiel espejo de la realidad.
La teoría del Framing vino a romper con las pretensiones objetivistas al introducir el elemento subjetivo como parte fundamental en el proceso comunicativo. Las noticias no son un reflejo de la realidad sino una representación de la misma. Los periodistas dependiendo de sus orientaciones ideológicas, culturales, religiosas, de sus experiencias y vivencias personales construyen la realidad desde un punto de vista subjetivo. Y no sólo es el periodista quien en su acontecer diario enfoca la información sino que la concepción del Framing puede trasladarse a los distintos niveles del proceso informativo, de modo que cualquiera de los elementos que intervienen en el mismo puede enfocar o encuadrar la información.
Los estudios de Comunicación Social en el EEES y los desafíos profesionales emergentes
Authors: MENESES FERNÁNDEZ María Dolores , GONZÁLEZ GONZÁLEZ Carina Soledad 
Published: October 2018

Los títulos de Comunicación Social despejan una nueva consideración universitaria de un sector público que aúna las facetas económica y cultural: las industrias audivisuales, periodística y publicitaria. Este artículo revisa cómo la sociedad de la información, la comunicación y el conocimiento y el mercado laboral obligan a potenciar la formación universitaria en competencias demandadas por las industrias creativo-culturales. Estamos ante un nuevo encaje de la universidad en el mundo profesional y la sociedad. Un mundo global abierto por las tecnologías de la información y de la comunicación reaviva la competitividad basada en la formación altamente cualificada, apelando a la conciliación entre universidad y empresa que afrontan la readecuación de unas interrelaciones no siempre bien entendidas.
Conocimiento, política y lenguaje: un análisis contrapolítico
Authors: MARTÍN ARIAS Luis 
Published: October 2018

El estudio del Lenguaje permite establecer la estrecha conexión entre, por un lado, los problemas de la comunicación en política, al cuestionar esa fantasía imaginaria de una sociedad civil basada en una opinión pública bien informada, conformada por ciudadanos que buscan el bien común y, por otra parte, los debates sobre cómo adquirimos o no un verdadero conocimiento a través de las Ciencias exactas y naturales o de las Humanidades; de tal modo que estas cuestiones deben entenderse en sus implicaciones políticas; aunque analizadas desde una cierta distancia, que nosotros denominamos Contrapolítica.