bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lepageite, Mn32+(Fe73+Fe42+)O3[Sb53+As83+O34], a new arsenite-antimonite mineral from the Szklary pegmatite, Lower Silesia, Poland
Authors: Pieczka Adam , Cooper Mark A. , Hawthorne Frank C. 
Published: July 2019

Abstract
Lepageite, a new arsenite-antimonite mineral, was discovered in a granitic pegmatite hosted by serpentinites of the Szklary massif, Lower Silesia, southwest Poland. Lepageite is a primary mineral formed during injection of an evolved LCT-type melt related to anatectic processes within the metasedimentary-metavolcanic complex of the nearby Góry Sowie Block, ~380 Ma, into serpentinite of the Szklary massif and its contamination by fluid-mobile serpentinite-hosted elements, among others As and Sb, transported in the form of H2AsO3− and HSbO2 species at pH ≈ 9–11 and a low redox potential of –0.7 to –0.3 V.
Ozonation process intensification of p-nitrophenol by in situ separation of hydroxyl radical scavengers and microbubbles
Authors: Cheng Wen , Jiang Li , Quan Xuejun , Cheng Chen , Huang Xiaoxue , Cheng Zhiliang , Yang Lu 
Published: July 2019

Abstract
The ozonation efficiency for removal of recalcitrant organic pollutants in alkaline wastewater is always low because of the presence of some hydroxyl radical scavengers. To solve this problem, the O3/Ca(OH)2 system was put forward, and p-nitrophenol (PNP) was chosen to explore the mechanism of this system. The effects of key operational parameters were studied respectively; the Ca(OH)2 dosage 3 g/L, ozone inlet flow rate 3.5 L/min, ozone concentration 65 mg/L, reactor pressure 0.25 MPa, and temperature 25 °C were obtained as the optimal operating conditions. After 60 min treatment, the organic matter mineralized completely, which was higher than the sum of the ozonation-alone process (55.63%) and the Ca(OH)2 process (3.53%). It suggests that the calcium hydroxide in the O3/Ca(OH)2 process possessed a paramount role in the removal of PNP. The liquid samples and the precipitated substances were analyzed by gas chromatography mass spectrometry, X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy; it was demonstrated that Ca(OH)2 could accelerate the generation of hydroxyl radical and simultaneously in situ separate partial intermediate products and CO32− ions through some precipitation reactions.
Antimicrobial Peptides-based Nanostructured Delivery Systems: An Approach for Leishmaniasis Treatment
Authors: Rodríguez-Carlos Adrian , Martinez-Gutierrez Fidel , Torres-Juarez Flor , Rivas-Santiago Bruno 
Published: July 2019

Background:Leishmaniasis is a major health problem mainly in tropical and subtropical areas worldwide, although in the last decades it has been treated with the use of conventional drugs such as amphotericin, the emergence of multidrug-resistant strains has raised a warning signal to the public health systems thus a new call for the creation of new leishmanicidal drugs is needed.Methods:The goal of this review was to explore the potential use of antimicrobial peptides-based nanostructured delivery systems as an approach for leishmaniasis treatment.Results:Within these new potential drugs, human host defense peptides (HDP) can be included given their remarkable antimicrobial activity and their outstanding immunomodulatory functions for the therapy of leishmaniasis.:Though several approaches have been done using these peptides, new ways for delivering HDPs need to be analyzed, such is the case for nanotechnology.
Reviewing the Mechanistic Evidence Assessors E-Synthesis and EBM+: A Case Study of Amoxicillin and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Authors: Abdin Ahmad Y. , Auker-Howlett Daniel , Landes Jürgen , Mulla Glorjen , Jacob Claus , Osimani Barbara 
Published: July 2019

Background:
Basic science has delivered unprecedented insights into intricate relationships on the
smallest scales within well-controlled environments. Addressing pressing societal decision problems requires an
understanding of systems on larger scales in real-world situations.

Objective:
To assess how well the evidence assessors E-Synthesis and EBM+ assess basic science findings to
support medical decision making.

Method:
We demonstrate the workings of E-Synthesis and EBM+ on a case study: the suspected causal connection
between the widely-used drug amoxicillin (AMX) and the putative adverse drug reaction: Drug Reaction
with Eosinophilia and Systemic Symptoms (DRESS).

Results:
We determine an increase in the probability that AMX can cause DRESS within the E-Synthesis approach
and using the EBM+ standards assess the basic science findings as supporting the existence of a mechanism
linking AMX and DRESS.

Conclusions:
While progress is made towards developing methodologies which allow the incorporation of basic
science research in the decision making process for pressing societal questions, there is still considerable need for
further developments. A continued dialogue between basic science researchers and methodologists, philosophers
and statisticians seems to offer the best prospects for developing and evaluating continuously evolving methodologies.
Preparation and Characterization of the Biological Compound Effervescent Granule of Calcium Acetate
Authors: Liu Zhongbing , Sun Xuemei , Liang Tiantian , Luo Yi , Chen Xiaoyan , Li Ting , Chen Lin , Wang Junjie , Lin Yan , Ye Yun , Zhong Zhirong 
Published: July 2019

Objective:
Calcium acetate (Ca(CH3COO)2) is commonly used in calcium supplement for
medicine, which is used as an auxiliary agent to treat osteoporosis. An effervescent granule is widely
used in medical industry due to its palatability. The purpose of this study is to develop a new preparation
of compound effervescent granule of the biological calcium acetate (Ca(CH3COO)2 effervescent
granule), overcoming the disadvantages of the previous other dosage forms of calcium and thus enhancing
the therapeutic efficacy.

Methods:
The biological Ca(CH3COO)2 effervescent granule was prepared by the wet granulation
method. The formulation was optimized by the orthogonal experiment. The effervescent base was
comprised of various amounts of citric acid and sodium bicarbonate. Other ingredients were added for
optimal performance of effervescent granule. The performed Ca(CH3COO)2 effervescent granule was
evaluated for the particle size, repose angle, pH value of solution, calcium acetate content and effervescence
time. The in vivo effects of Ca(CH3COO)2 effervescent granule on the bone microarchitecture
were investigated via Micro-CT detection, and the serum calcium level was also investigated.

Results:
The optimized formulation of the biological Ca(CH3COO)2 effervescent granules was composed
of calcium acetate, citric acid, sodium bicarbonate, PEG6000, aspartame, PVP ethanol solution,
lactose and vitamin D. Our findings reveal that this biological Ca(CH3COO)2 effervescent granule exhibited
prominent effect on preventing the bone-mass loss and did better in enhancing the bone microarchitecture
compared to the other calcium preparations.

Conclusion:
The biological Ca(CH3COO)2 effervescent granule is a novel dosage form among so
many kinds of calcium preparations. It may perform better functions in the dairy calcium supplement.
An Improved Scatter Search Algorithm for Parameter Estimation in Large-Scale Kinetic Models of Biochemical Systems
Authors: Remli Muhammad Akmal , Mohamad Mohd Saberi , Deris Safaai , Sinnott Richard , Napis Suhaimi 
Published: July 2019

Background:
Mathematical models play a central role in facilitating researchers to better
understand and comprehensively analyze various processes in biochemical systems. Their usage is
beneficial in metabolic engineering as they help predict and improve desired products. However, one
of the primary challenges in model building is parameter estimation. It is the process to find nearoptimal
values of kinetic parameters which may culminate in the best fit of model prediction to experimental
data.

Methods:
This paper proposes an improved scatter search algorithm to address the challenging parameter
estimation problem. The improved algorithm is based on hybridization of quasi opposition-based
learning in enhanced scatter search (QOBLESS) method. The algorithm is tested using a large-scale
metabolic model of Chinese Hamster Ovary (CHO) cells.

Results:
The experimental result shows that the proposed algorithm performs better than other algorithms
in terms of convergence speed and the minimum value of the objective function (loglikelihood).
The estimated parameters from the experiment produce a better model by means of obtaining
a reasonable good fit of model prediction to the experimental data.

Conclusion:
The kinetic parameters’ value obtained from our work was able to result in a reasonable
best fit of model prediction to the experimental data, which contributes to a better understanding and
produced more accurate model. Based on the results, the QOBLESS method can be used as an efficient
parameter estimation method in large-scale kinetic model building.
Structural and Functional Analysis of Mutated Human Pyrin B30.2 Domain
Authors: Parvizpour Sepideh , Jomah Ashraf Fadhil , Razmara Jafar 
Published: July 2019

Background:
Familial Mediterranean Fever (FMF) is a prototypical hereditary
autoinflammatory disease affecting principally Mediterranean populations and characterized by
recurrent frequent fever and inflammation. The disease is essentially caused by inherited mutations in
the MEFV gene which encodes pyrin protein. The reported mutations are mostly located on the B30.2
domain in the C-terminal end of the protein.

Objective:
The present study reports a structural comparison of the five most common mutated
structures including M694V, V726A, M694I, R761H, and M680I. The aim of this study was to
determine the structural and functional disorders caused by the mutations in the human pyrin protein.

Results:
The comparison revealed that all mutations make overall changes in the structure of the
domain. Further, the effects of these mutations on structural and molecular behavior of the B30.2
domain were compared with the native structure using MD simulation by GROMACS software. The
results revealed that all the studied mutants have a destabilizing effect on the protein structure.
Additionally, analyzing the projection of the motions of the proteins in phase space demonstrates high
rigidity of the mutated structures in comparison with the native protein.

Conclusion:
The results of simulations elucidate how the mutations affect the physiological
functioning of the pyrin B30.2 domain and cause the occurrence of the FMF disease.
Design, Synthesis, Insecticidal Evaluation and Modeling Studies on 1,4,6,7- tetrahydropyrazolo[3,4-d][1,3]oxazine Derivatives: An Application of Scaffold Hopping Strategy on Fipronil
Authors: Li Guanglong , Zhou Cong , Zhu Chengchun , He Lujue , Li Xiaoyang , Xu Zhiping , Xu Xiaoyong , Shao Xusheng , Li Zhong , Cheng Jiagao 
Published: July 2019

Background::As the first phenylpyrazole pesticide, fipronil has been widely used in crop protection and public hygiene. In the low energy conformation of fipronil, a pseudo-six-membered ring is observed through an intramolecular hydrogen bond.Methods: :A scaffold hopping strategy was applied to mimic the pseudo-six-membered ring of fipronil by non-aromatic ring. All compounds were synthesized with a proper synthetic route and characterized by 1H NMR, 13C NMR and high-resolution mass spectra. Insecticidal activities of all target compounds against Plutella xylostella were assessed by a professional organization. Physicochemical property prediction and docking study of these compounds with GABA receptor were also performed.Results::A series of 1,4,6,7-tetrahydropyrazolo[3,4-d][1,3]oxazine derivatives containing twenty-five compounds were designed, synthesized and evaluated. Several compounds exhibited moderate activities against Plutella xylostella. The strong electron-withdrawing groups are conducive to improve activities of this series of compounds against Plutella xylostella. Docking study showed that the most active compound 10 with nitro group could bind within the TM2 domain of GABA receptor, in which a hydrogen bond was observed with residue 6’Thr. The activity of 10 was weaker than fipronil due to the differences in physicochemical properties.Conclusion: :More attention should be paid to physicochemical properties during novel pesticide hit or lead design through scaffold hopping.
Natural Products from Mediterranean Diet: From Anti-hyperlipidemic Agents to Dietary Epigenetic Modulators
Authors: Georgia-Eirini Deligiannidou , Athina Sygkouna , Wim Vanden Berghe , Christos Kontogiorgis , Theodoros Constantinides 
Published: July 2019

Background:Cardiovascular Diseases (CVD) are, currently, the major contributor to global mortality and will continue to dominate mortality rates in the future. Hyperlipidemia refers to the elevated levels of lipids and cholesterol in the blood, and is also identified as dyslipidemia, manifesting in the form of different disorders of lipoprotein metabolism. These abnormalities may lead to the development of atherosclerosis, which can lead to coronary artery disease and stroke. In recent years, there is a growing interest in the quest for alternative therapeutic treatments based on natural products, offering better recovery and the avoidance of side effects. Recent technological advances have further improved our understanding of the role of epigenetic mechanisms in hyperlipidemic disorders and dietary prevention strategies.Objective:This is a comprehensive overview of the anti-hyperlipidemic effects of plant extracts, vegetables, fruits and isolated compounds thereof, with a focus on natural products from the Mediterranean region as well as the possible epigenetic changes in gene expression or cardiometabolic signaling pathways.Methods:For the purpose of this study, we searched the PubMed, Scopus and Google Scholar databases for eligible articles and publications over the last five years. The keywords included: “hyperlipidemia”, “plant extract”, “herbs”, “natural products”, “vegetables”, “cholesterol” and others. We initially included all relevant articles referring to in vitro studies, animal studies, Randomized Controlled Trials (RCTs) and previous reviews.Conclusion:Many natural products found in the Mediterranean diet have been studied for the treatment of hyperlipidemia. The antihyperlipidemic effect seems to be dose and/or consumption frequency related, which highlights the fact that a healthy diet can only be effective in reversing disease markers if it is consistent and within the framework of a healthy lifestyle. Finally, epigenetic biomarkers are increasingly recognized as new lifestyle management tools to monitor a healthy dietary lifestyle for the prevention of hyperlipidaemic disorders and comorbidities to promote a healthy life.
Meniscal Lesions in Geriatric Population: Prevalence and Association with Knee Osteoarthritis
Authors: Özdemir Meltem , Kavak Rasime 
Published: July 2019

Objective:
This study evaluated the prevalence of different types of meniscal lesions
among elderly patients with knee pain. Moreover, this study assessed the relationship between meniscal
lesions and the presence of radiographic knee osteoarthritis (OA) in the elderly population.

Methods:
The radiographs and magnetic resonance images of one knee out of 306 patients with
knee pain aged 65-89 years were reviewed for knee OA and meniscal lesions. The prevalence of
different types of meniscal lesions was calculated, and the relationship between the prevalence of
meniscal lesion types and the presence of radiographic knee OA was analyzed.

Results:
Among 306 participants, 274 (89.5%) showed radiographic knee OA. We found one or
more meniscal lesion(s) in 93% of the total subjects, in 94% of all patients with knee OA, and in
84% of all patients without knee OA. The prevalence of surgically target, possible-target, and nontarget
lesions were 24%, 72%, and 69%, respectively. The prevalence of surgically target lesions
was significantly higher in patients with knee OA than in those without it. The most common lesion
observed was meniscal extrusion, followed by the horizontal and complex meniscal tears.

Conclusions:
Our results demonstrated that meniscal damage is considerably prevalent among elderly
individuals with knee pain, especially in those with knee OA. The fact that surgically target
and possible-target lesions constitute a substantial proportion of these lesions should be considered
in the clinical approach to these patients.
Research Progress and New Patents of Magnetic Grinding Machine
Authors: Li Yuan , Dai Ye , Qi Yunshan , Gao Yufei 
Published: July 2019

Background:
Mechanical parts in processing and manufacturing process will produce burr,
scratches and other surface quality problems, which have adverse effects on the precision, use, reprocessing
location, operation safety and appearance quality of the parts, so it is necessary to grind the
workpiece surface.

Objective:
Based on the recent development in the field of magnetic grinding and related patent research,
it can provide reliable help to solve the problem of finishing the surface of parts with complex
shapes and small volumes.

Methods:
This paper reviewed some patents and research advances related to magnetic abrasive finishing,
and the advantages and disadvantages of the magnetic grinding machine in the finishing process
were summarized. The outstanding grinding effect of the new vibration assisted magnetic grinder was
introduced.

Results:
The working characteristics of various magnetic grinding machines were summarized, and the
development trend of magnetic grinding and finishing was prospected.

Conclusion:
Magnetic abrasive finishing has good flexibility, strong self-sharpening, wide applicable
scope, high processing efficiency, simple processing equipment and low cost. It can control the grinding
efficiency and grinding precision. The machining efficiency and quality of magnetic grinding can
be improved with the appropriate amplitude of vibration assist, and the surface quality can be improved
significantly.
Pengembangan video pembelajaran sinyal-sinyal wasit bola basket untuk guru penjasorkes sekolah menengah atas
Authors: Pambudi Duwi Kurnianto , Suharjana Suharjana 
Published: July 2019

Penelitian ini bertujuan untuk mengembangkan video pembelajaran sinyal-sinyal wasit sesuai dengan Fiba rules 2014 untuk Guru Penjasorkes SMA. Metode penelitian ini meliputi : (1)potensi dan masalah, (2) pengumpulan data, (3) desain produk, (4) validasi desain, (5) revisi desain, (6) ujicoba produk, (7) revisi produk, (8) ujicoba pemakaian, (9) revisi produk,(10) produksi masal. Subjek penelitian ini berjumlah 33 guru. Pengumpulan data menggunakan angket lembar penilaian produk dengan disertai lembar saran dan masukan untuk revisi produk. Analisis data menggunakan teknik analisis deskriptif dengan menggunakan persentase. Hasil penelitian adalah sebagai berikut: hasil validasi ahli media dan ahli materi menunjukkan nilai 88,58% dan berkategori sangat tinggi. Hasil ujicoba produk menunjukkan nilai 93,33% berkategori sangat tinggi. Hasil ujicoba pemakaian menunjukkan nilai 92,59%, berkategori sangat tinggi. Hasil uji efektifitas/ uji operasional data pretest dan post test pada uji efektifitas/ uji operasional menunjukkan peningkatan rata-rata nilai sebesar 9,09% yaitu dari 74,24% pada saat pretest menjadi 818,33% pada saat post test. Developing Learning Video of Basketball Referee Signals for Physical Education Teachers in Senior High School AbstractThis research aims to develop learning video of basketball referee signals based on Fiba Rules 2014 to physical education teacher of the senior high school. This research method includes: (1) the potentials and problems, (2) data collection, (3) the design of the product, (4) design validation, (5) design revisions, (6) test products, (7) product revision, (8 ) user trial, (9) the revision of the product, (10) the mass production. Subjects of this study are 33 teachers. Collecting data using a questionnaire sheet product assessment, accompanied by pieces of advice and input for the revision of the product. Data analysis using descriptive analysis techniques using percentages. The results of the study are as follows: the results of validation media experts and subject matter experts demonstrate the value of 88.58% and a very high category. The trial results demonstrate the value of 93.33% product category is very high. User trial results demonstrate the value of 92.59%, a very high category. The results of effectiveness test / operational test data are pre-test and post-test on the effectiveness test / operational test showed an average increase in value by 9.09% from 74.24% at the time of the pre-test be 818.33% at the post-test.
Motivasi berolahraga atlet atletik dan tinju
Authors: Blegur Jusuf , Mae Ramona Mathias 
Published: July 2019

Tujuan penelitian ini adalah untuk melakukan uji perbandingan motivasi berolahraga antara atlet atletik dan atlet tinju di Pusat Pendidikan dan Latihan Pelajar Provinsi Nusa Tengara Timur dengan melibatkan 26 orang sampel (13 atlet atletik dan 13 atlet tinju). Penelitian ini menggunakan pendekatan kuantitatif dengan desain komparatif. Data penelitian dikumpulkan menggunakan The Sport Motivational Scale (SMS) yang dikembangkan oleh Luc G. Pelletier, Michelle Fortier, Robert J. Vallerand, Nathalle M. Briere, Kim M. Tuson, dan Marc R. Blais pada tahun 1995. Hasil penelitian menunjukkan bahwa motivasi berolahraga atlet atletik dan tinju tergolong baik, masing-masing 69.2% dan 92.3%. Nilai rata-rata atlet tinju lebih tinggi daripada atlet atletik, namun nilai standar deviasi atlet atletik lebih tinggi daripada atlet tinju. Secara umum, tidak ada perbedaan yang signifikan antara rata-rata variabel motivasi berolahraga atlet atletik dan atlet tinju (0.703 > 0.05). Akan tetapi, pada sub variabel motivasi intrinsik-to experience stimulation, terdapat perbedaan yang signifikan (0.004 < 0.05) dari kedua kelompok sampel penelitian. Sport motivation of athletic and boxing athleetes AbstractThe objective of this research is to do a comparison test between athletic and boxing athletes’ sport motivation in Student Education and Training Center, East Nusa Tenggara by involving 26 athletes as the sample (13 athletic athletes and 13 boxing athletes).This research used quantitative approach with comparative design. Data was collected using The Sport Motivation Scale (SMS) created by Luc G. Pelletier, Michelle Fortier, Robert J. Vallerand, Nathalle M. Brierre, Kim M. Tuson, and Marc R. Blas in 1995. The result indicates that the level of athletic and boxing athlete’s’ sport motivation was good, respectively 69.2% and 92.3%. The average value of the boxing athletes is higher than the athletic athletes while the standard deviation value of the athletic athletes is higher than the boxing athletes. Generally, there is no significant difference between sport motivation toward the two sample groups (0.703 > 0.05). However, there is a significant difference (0.004 < 0.05) in sub-variables of intrinsic motivation to experience stimulation from both research sample groups.