bluuebunny/crossref_metadata_2025_split huggingface dataset:
P102 Young Investigator, Top Clinical Abstract Combined therapy with adalimumab and mesenchymal stromal cells contributes to reduction in the degree of inflammation in ulcerative colitis
Authors: Oleg Knyazev , Anna Kagramanova , Albina Lishchinskaya , Dmitriy Kulakov , Anatoliy Konoplyannikov , Mariya Zvyaglova , Sergey Khomeriki , Asfold Parfenov 
Published: July 2019

BACKGROUND:
One of the new promising methods of treatment of patients with ulcerative colitis (UC) is biological therapy using bone marrow mesenchymal stromal cells (MCS). In some cases, simultaneously with MCS, patients receive concomitant anticytokine therapy. Currently, a new strategy for UC therapy is to achieve a deep remission of the disease. Objective: to compare the level of immunobiological and histological markers of inflammation – C-reactive protein (CRP), the Histological Geboes Score (GS) and fecal calprotectin (FCP) - in patients with UC receiving cell therapy MSC, anticytokine therapy with adalimumab (ADA) and combined therapy of bone marrow MSC and ADA.

METHODS:
60 patients with total ulcerative colitis of moderate severity were divided into groups depending on the therapy. The first group of patients with UC aged from 19 to 56 years (Me-29) (n = 20) received anti-inflammatory therapy with the use of the culture of 2 million MSC/kg according to the scheme the second group of patients with UC (n = 20) aged 23 to 62 years (Me-41) received ADA in accordance with the recommended scheme, the third group of patients with UC (n = 20) aged 20 to 59 years (Me-33) received the MSC + ADA. The level of CRP, PCF and is was assessed 26 weeks after initiation of therapy. The baseline CRP was 25.0 ± 1.9; 26.5 ± 2.1 and 24.0 ± 2.4 mg/L, respectively. Baseline GS in the groups of patients was 4.4 ± 0.2; 4.35 ± 0.2 and 4.5 ± 0.3 points, respectively. The initial level of the FCP made 890.8 ± 88,8; 850.3 ± 83.9 and 910.5 ± 120.5 μg/g, respectively.

RESULTS:
After 26 weeks from the start of therapy in the 1-st group of patients, the level of CPP was 6.8 ± 1.1 mg/L, in the 2-nd group-7.4 ± 1.3 mg/L, in the 3-rd group-7.9 ± 1.0 mg/L (P > 0.05). After 26 weeks from the start of therapy in the 1-st group of patients, the level of FCP was 108.8 ± 9.3 μg/g, in the 2-nd group-90.6 ± 6.5 μg/g, in the 3-rd group - 96.8 ± 6.3 μg/g (P < 0.05 compared to the 1-st and 2-nd groups). After 26 weeks from the start of therapy in the 1-st group of patients with GS was 0.7 ± 0.1 points, in the 2-nd group-0.65 ± 0.1 points, in the 3-rd-0.5 ± 0.06 points (P < 0.001 compared with the 1-st and 2-nd groups).

CONCLUSION(S):
Combined cell and anti-cytokine therapy with adalimumab contributes to a more pronounced reduction in the degree of inflammation of the intestinal mucosa.
P104 Branded infliximab still predominantly used over biosimilars in patients with IBD
Authors: Lynn Price 
Published: July 2019

BACKGROUND:
Despite the availability of 2 infliximab biosimilars in the US market, the vast majority of bio-naïve patients being placed on infliximab are prescribed the reference brand.

METHODS:
In April 2018, we conducted a retrospective patient chart audit of 1,005 patients with IBD who were started on a biologic agent for the first time. 209 US gastroenterologists submitted patient-level data via a HIPAA-compliant audit form which included both clinical and non-clinical data. The collaborating physicians also completed a brief survey about their practices and their opinions regarding IBD patient management. The data were collected and analyzed in SPSS.

RESULTS:
30% of the patients starting on a biologic for the first time were initiated on infliximab. Of those, 16% were placed on a biosimilar and 84% were placed on the reference brand. When presented with the statement, “I trust that infliximab biosimilars are clinically comparable to the reference brand,” 46% of the physicians expressed agreement, 36% were neutral, and 18% disagreed. In 90% of the cases where the patient was placed on the reference brand, the physician was not contacted by a pharmacist or insurance company about using a biosimilar in place of the reference brand. If they had been contacted, in 43% of the cases they would have switched to a biosimilar, in 51% they would have pressed to use the reference brand, and in 6% they would have chosen a non-infliximab alternative.

CONCLUSION(S):
Until gastroenterologists are encouraged or mandated to use biosimilars, use of the reference brand is anticipated to remain dominant. Based on physician feedback, about half appear to be very willing to use biosimilars, but despite this, continue to prescribe the more familiar reference brand.
P105 Biologic/JAK preference in different IBD patient types
Authors: Lynn Price 
Published: July 2019

BACKGROUND:
The IBD market is rapidly evolving as new biologic and small molecule agents are being approved such as ustekinumab in Crohn's disease and tofacitinib in ulcerative colitis (UC). This study sought to understand gastroenterologists' product preferences for certain patient types and to understand any shifts in preference with new agents to consider.

METHODS:
Each quarter, an independent healthcare agency surveys approximately 100 US gastroenterologists about the evolving treatment of IBD. To qualify, gastroenterologists must spend the majority of time in clinical practice, must be managing a minimum of 50 patients with IBD, and must be in practice between 2 and 35 years. Regional and practice setting quotas are applied in order to obtain a representative sample. The survey is administered online and respondents are compensated for their participation. The data are collected and analyzed in SPSS.

RESULTS:
Gastroenterologists describe over half of their UC patients as being “young, with active lifestyles”. This patient type has historically been strongly associated with adalimumab over other biologic agents, with 64% (n = 100) of respondents surveyed in April 2018 indicating that they would be most likely to use adalimumab for this patient category. However, with the availability of tofacitinib, which was approved in June 2018, preference for this large patient segment is changing. In the July 2018 wave of the survey, nearly one-quarter (23%) of gastroenterologists selected the new, oral JAK inhibitor as their most likely agent of choice for young, active patients, with adalimumab preference dipping to 54%. Tofacitinib was also selected by 16% of the gastroenterologists as being the drug of choice in patients with secondary TNF failures (waning efficacy), though the majority still prefer vedolizumab in this scenario (58%). When directly comparing adalimumab with tofacitinib in UC, gastroenterologists view adalimumab outperforming tofacitinib on all attributes associated with length of time in the market, but tofacitinib is already matching, or outpacing, adalimumab on many key attributes for treatment success including efficacy, adherence, tolerability, and sustained response. Analysis of the most recent prescription patterns, as assessed by physician allocation of their last 5 biologic/JAK prescriptions between April 2018 and July 2018 shows declining use of adalimumab (34% to 30%) with an increase of tofacitinib (0% to 5%).

CONCLUSION(S):
Adalimumab has long been the preferred biologic agent for the treatment of UC in younger, active patients, relatively unchallenged by any of the other biologics for this large patient sub-type. Early use of tofacitinib suggests that the advent of an oral advanced therapy option may soon rival adalimumab for preference in younger, active patients.
Pengidentifikasian Huruf Hijaiyah yang Bentuknya Sama Sebagai Strategi Peningkatan Motivasi dan Keberhasilan Membaca Iqro’ Pada Siswa SDLB Tunagrahita Ringan (C)
Authors: Rohmatin Fitriyah 
Published: July 2019

Penelitian ini bertujuan untuk mengetahui efektivitas pengidentifikasian huruf hijaiyah yang bentuknya sama dengan menggunakan kartu bertulisan huruf hijaiyah dan papan panel sebagai strategi peningkatan motivasi dan keberhasilan membaca Iqro’ bagi siswa SDLB tunagrahita ringan (C) Bhakti Kencana Berbah, Sleman, Yogyakarta.Penelitian ini merupakan kolaboratif. Setting penelitian yang dipilih adalah di dalam di luar kelas pada jam pelajaran Pendidikan Agama Islam kelas III yang terdiri dari 4 siswa.Langkah-langkah penelitian ini mencoba menggunakan model desain yang dikembangkan oleh Kemmis & MC. Taggert yang terdiri empat tahap yang meliputi perencanaan, tindakan, pengamatan, dan refleksi. Keempat tahapan ini sebagai untaian dalam satu siklus. Adapun alat monitoring menggunakan observasi kelas, catatan lapangan, untuk evaluasi dapat diketahui dari proses dan hasil pembelajaran. Analisis data yang digunakan adalah analisis deskriptif non statistik. Adapun penelitian dibagi menjadi dua siklus. Pada siklus I pembelajaran huruf hijaiyah belum memperoleh hasil yang maksimal, sebagai bukti siswa-siswa kurang semangat, masih keliru terbalik dalam melafadzkan beberapa huruf hijaiyah, hal ini karena ada beberapa hal yaitu: 1. Pada siklus I dalam mengenalkan huruf hijaiyah disertai huruf latinnya, dalam pengenalan huruf hijaiyah diurutkan, sehingga apabila diacak siswa sering kebalik. 2. Papan panel yang digunakan hanya satu dipasang dipapan tulis, sehingga anak sering berebutan untuk maju, hal ini mengganggu proses pembelajaran.Berdasarkan hasil evaluasi siklus I, peneliti mengadakan perbaikan pada siklus ke II antara lain: 1). Dalam pengenalan huruf hijaiyah tanpa disertai huruf latinnya, dalam membaca huruf hijaiyah tidak diurutkan/ diacak, tetapi membacanya sesuai kelompok huruf yang bentuknya sama dan diulang-ulang sampai siswa paham. 2). Saat membaca direkam, setelah selesai bisa mendengarkan suaranya sendiri, sehingga siswa mengetahui pelafadzan yang belum benar. 3). Alat Bantu yang digunakan disiapkan sesuai jumlah siswa, sehingga siswa tidak berebutan, bagi siswa yang belum mendapat giliran bisa mencoba sendiri di mejanya masingmasing. Untuk melatih motorik, siswa yang sudah mendapat giliran, mendapat tugas untuk menyalin materi yang telah dipelajari. Sehingga dalam siklus ke II ini pembelajarannya lebih kondusif, siswa lebih senang, perhatian, semangat, sebagai bukti siswa sudah mampu membaca huruf hijaiyah dan mampu menyelesaikan Iqro’ jilid I dengan benar dan lancar dan mulai Iqro’ II. Berdasarkan hasil yang diperoleh bahwa pengidentifikasian huruf hijaiyah yang bentuknya sama dengan alat Bantu karton yang bertulisan huruf hijaiyah dan papan panel, walaupun alat tersebut sederhana, dapat meningkatkan keberhasilan membaca huruf hijaiyah/ Iqro’ bagi siswa SDLB III SLB C Bhakti Kencana Berbah Sleman, Yogyakarta.
Homeland as Sound and Sound as Homeland: Cultural and Personal Soundscapes in Christos Christovasilis's Short Stories. By Panayotis Panopoulos. Translated by Vasiliki Chatzopoulou.
Authors: Panopoulos Panayotis , Chatzopoulou Vasiliki 
Published: July 2019

This essay is an original contribution to the ethnomusicology of literature in Greece. Concepts and perspectives from the anthropology of music, soundscape studies, and the ethnography of sound and the senses are used to approach and analyze the sound world of Christos Christovasilis’s literary work. Christovasilis (1860-1937) is an important figure in the so-called “ethographic” literary movement in Greece of the late 19th and early 20th centuries; his work is of exceptional interest concerning the presentation of sound and hearing in Greek mountain communities. Panayotis Panopoulos’s sharp ear identifies the strong presence of sound in the short stories of Christovasilis, which he interprets in terms of the ethnography of the senses and the role of sound and hearing in the cultural construction of community and personhood among Greek pastoralists. In this text Panopoulos places special emphasis on the sound of animal bells in everyday and ritual contexts, developing further his earlier ethnographic work on animal bells (see “Animal Bells as Symbols: Sound and Hearing in a Greek Island Village,”Journal of the Royal Anthropological Institute 9 (2003): 639-56; and Skyros Carnival, photographs by Dick Blau, essay by Agapi Amanatidis and Panayotis Panopoulos, CD + DVD by Steven Feld, Santa Fe, NM: VOXLOX, 2011). More importantly, Panopoulos challenges received ideas in which text is understood as a predominantly visual, linguistic construct and he eloquently depicts how experiences of sonic imagination are culturally reproduced in text. In this way, he makes an important contribution to the ethnomusicological reading of literary text by showing how text is mediated through acoustic environment and how sound produces, surrounds, and immerses itself in text.
Citation: Panopoulos, Panayotis. Homeland as Sound and Sound as Homeland: Cultural and Personal Soundscapes in Christos Christovasilis’s Short Stories. Translated by VasilikiChatzopoulou. Ethnomusicology Translations, no. 1. Bloomington, IN: Society for Ethnomusicology, 2015.
Originally published in Greek in Dokimes: Journal of Social Studies 13-14 (2005): 277-307.
Writing against Europe: On the Necessary Decline of Ethnomusicology. By Martin Greve. Translated by Férdia J. Stone-Davis.
Authors: Greve Martin , Stone-Davis Férdia J. 
Published: July 2019

In this appraisal of then-current German-speaking ethnomusicology, Martin Greve calls for much more critical acknowledgment and consideration of recent key debates in cultural studies and cultural anthropology. The essay and its provocative title, certainly written in a constructive spirit, hit a trouble spot, fueling the fear of losing ethnomusicology’s disciplinary raison d’être. A short but telling discussion among German-speaking ethnomusicologists ensued.
Citation: Greve, Martin. Writing against Europe:On the Necessary Decline of Ethnomusicology. Translated by Férdia J. Stone-Davis. Ethnomusicology Translations, no. 3. Bloomington, IN: Society for Ethnomusicology, 2016.
Originally published in German as “‘Writing against Europe’: Vom notwendigen Verschwinden der Musikethnologie,” Musikforschung 55 (2002): 239-250.
Comparative study on amylosucrases derived from Deinococcus species and catalytic characterization and use of amylosucrase derived from Deinococcus wulumuqiensis
Authors: Kim Ki-Tae , Rha Chan-Su , Jung Young Sung , Kim Ye-Jin , Jung Dong-Hyun , Seo Dong-Ho , Park Cheon-Seok 
Published: July 2019

Abstract
Amylosucrase (ASase; EC 2.4.1.4), a versatile enzyme, exhibits three characteristic activities: hydrolysis, isomerization, and transglycosylation. In this study, a novel ASase derived from Deinococcus wulumuquiensis (DWAS) was identified and expressed in Escherichia coli. The optimal reaction temperature and pH for the sucrose hydrolysis activity of DWAS were determined to be 45 °C and 9.0, respectively. DWAS displays relatively high thermostability compared with other ASases, as demonstrated by half-life of 96.7 and 4.7 min at 50 °C and 55 °C, respectively. DWAS fused with 6×His was successfully purified to apparent homogeneity with a molecular mass of approximately 72 kDa by Ni-NTA affinity chromatography and confirmed by SDS-PAGE. DWAS transglycosylation activity can be used to modify isovitexin, a representative flavone C-glucoside contained in buckwheat sprouts to increase its limited bioavailability, which is due to its low absorption rate and unstable structure in the human body. Using isovitexin as a substrate, the major transglycosylation product of DWAS was found to be isovitexin monoglucoside. The comparison of transglycosylation reaction products of DWAS with those of other ASases derived from Deinococcus species revealed that the low sequence homology of loop 8 in ASases may affect the acceptor specificity of ASases and result in a distinctive acceptor specificity of DWAS.
On a class of nonlocal nonlinear Schrödinger equations with potential well
Authors: Wu Tsung-fang 
Published: July 2019

Abstract
In this paper we investigate the existence, multiplicity and asymptotic behavior of positive solution for the nonlocal nonlinear Schrödinger equations. We exploiting the relationship between the Nehari manifold and eigenvalue problems to discuss how the Nehari manifold changes as parameters μ, λ changes and show how existence, multiplicity and asymptotic results for positive solutions of the equation are linked to properties of the manifold.
Numerical analysis of temperature distribution in a brush seal with thermo-regulating bimetal elements
Authors: Stanclik Michał 
Published: July 2019

Abstract
The paper presents the continuation of work devoted to the analysis of a brush seal with thermo-regulating bimetal elements aimed at thermal protection of a brush seal. This paper presents a method of determining the operating temperature of such a seal using the finite element method. It has been shown that building the seal according to the idea allows a significant reduction of its working temperature.
Judicial Examination of Complainants in Sexual Offense Cases
Authors: Menashe Doron , Gruner Eyal 
Published: July 2019

Abstract
This article concerns the ideal legal arrangement with respect to cross-examining complainants in sexual assault cases regarding their sexual history. The article examines the question of under what circumstances the complainant’s sexual history could be seen as as logically relevant. It also deals with finding the balance between, on the one hand, the interests of protecting the defendant and pursuing truth, which require cross-examination regarding the complainant’s sexual history, and on the other hand, the interest of protecting the complainant’s dignity and welfare.
The left Riemann-Liouville fractional Hermite-Hadamard type inequalities for convex functions
Authors: Kunt Mehmet , Karapinar Dünya , Turhan Sercan , İşcan İmdat 
Published: July 2019

Abstract
In this paper, with a new approach, a new fractional Hermite-Hadamard type inequalities for convex functions is obtained by using only the left Riemann-Liouville fractional integral. Also, to have new fractional trapezoid and midpoint type inequalities for the differentiable convex functions, two new equalities are proved. Our results generalize earlier studies. We expect that this study will be lead to the new fractional integration studies for Hermite-Hadamard type inequalities.
On the finite embeddability property for quantum B-algebras
Authors: Xia Changchun 
Published: July 2019

Abstract
After the establishment of the finite embeddability property for integral and commutative residuated ordered monoids by Blok and Van Alten in 2002, the finite embeddability property for some other types of residuated ordered algebraic structures have been extensively studied. The main purpose of this paper is to construct a finite quantale X̂F
from a finite partial subalgebra F of an increasing quantum B-algebra X so that F can be embedded into X̂F
, that is, the class of increasing quantum B-algebras has the finite embeddability property.
On a Choquet-Stieltjes type integral on intervals
Authors: Gal Sorin G. 
Published: July 2019

Abstract
In this paper we introduce a new concept of Choquet-Stieltjes integral of f with respect to g on intervals, as a limit of Choquet integrals with respect to a capacity μ. For g(t) = t, one reduces to the usual Choquet integral and unlike the old known concept of Choquet-Stieltjes integral, for μ the Lebesgue measure, one reduces to the usual Riemann-Stieltjes integral. In the case of distorted Lebesgue measures, several properties of this new integral are obtained. As an application, the concept of Choquet line integral of second kind is introduced and some of its properties are obtained.
Unified solution of Fekete-Szegö problem for subclasses of starlike mappings in several complex variables
Authors: Tu Zhenhan , Xiong Liangpeng 
Published: July 2019

Abstract
Let

S

ψ
∗

$\begin{array}{}
\mathcal {S}^*_\psi
\end{array}$

be a subclass of starlike functions in the unit disk 𝕌, where ψ is a convex function such that ψ(0) = 1, ψ′(0) > 0, ℜ(ψ(ξ)) > 0 and ψ(𝕌) is symmetric with respect to the real axis. We obtain the sharp solution of Fekete-Szegö problem for the family

S

ψ
∗

$\begin{array}{}
\mathcal {S}^*_\psi
\end{array}$

, and then extend the result to the case of corresponding subclass defined on the bounded starlike circular domain Ω in several complex variables, which give an unified answer of Fekete-Szegö problem for the kinds of subclasses of starlike mappings defined on Ω. At last, we propose two conjectures related the same problems on the unit ball in a complex Banach space and on the unit polydisk in ℂ
n
.
Some refinements of young type inequality for positive linear map
Authors: Yang Chaojun , Gao Yaxin , Lu Fangyan 
Published: July 2019

Abstract
We obtain a refined Young type inequality in this paper. The conclusion is presented as follows: Let A, B ∈ B(𝓗) be two positive operators and p ∈ [0, 1], then

A

♯
p

B
+

G
∗

(
A

♯
p

B
)
G
≤
A

∇
p

B
−
2
r
(
A
∇
B
−
A
♯
B
)
,

$$\begin{array}{}
\displaystyle
A\sharp_p B+G^*(A\sharp_p B)G\le A\nabla_p B-2r(A\nabla B-A\sharp B),
\end{array}$$

where r = min{p, 1 – p}, G =

L
(
2
p
)

2

$\begin{array}{}
\displaystyle
\frac{\sqrt{L(2p)}}{2}
\end{array}$

A
–1
S(A|B), L(t) is periodic with period one and L(t) =

t
2

2

1
−
t

t

2
t

$\begin{array}{}
\displaystyle
\frac{t^2}{2}\left( \frac{1-t}{t} \right)^{2t}
\end{array}$

for t ∈ [0, 1]. Moreover, we give the s-th powering of two inequalities related to the above one with s > 0 which refines Lin’s work. In the mean time, we present an inequality involving Hilbert-Schmidt norm.
Dielectric cross-shaped-resonator-based metasurface for vortex beam generation at mid-IR and THz wavelengths
Authors: Dharmavarapu Raghu , Izumi Ken-ichi , Katayama Ikufumi , Ng Soon Hock , Vongsvivut Jitraporn , Tobin Mark J. , Kuchmizhak Aleksandr , Nishijima Yoshiaki , Bhattacharya Shanti , Juodkazis Saulius 
Published: July 2019

Abstract
Metasurfaces are engineered thin surfaces comprising two-dimensional (2D) arrays of sub-wavelength-spaced and sub-wavelength-sized resonators. Metasurfaces can locally manipulate the amplitude, phase, and polarization of light with high spatial resolution. In this paper, we report numerical and experimental results of a vortex-beam-generating metasurface fabricated specifically for infrared (IR) and terahertz (THz) wavelengths. The designed metasurface consists of a 2D array of dielectric cross-shaped resonators with spatially varying length, thereby providing the desired spatially varying phase shift to the incident light. The metasurface was found to be insensitive to the polarization of the incident light. The dimensions of the cross-resonators were calculated using rigorous finite-difference time-domain analysis. The spectral scalability via physical scaling of the meta-resonators is demonstrated using two vortex-generating optical elements operating at 8.8 μm (IR) and 0.78 THz. The vortex beam generated in the mid-IR spectral range was imaged using a Fourier transform IR (FTIR) imaging miscroscope equipped with a focal plane array detector. This design could be used for efficient wavefront shaping and various optical imaging applications in the mid-IR spectral range, where polarization insensitivity is desired.