bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interrelation of pericoronary adipose tissue texture and coronary artery disease of the left coronary artery in cardiac photon-counting computed tomography
Authors: Kahmann Jannik , Nörenberg Dominik , Papavassiliu Theano , Schoenberg Stefan O. , Froelich Matthias F. , Ayx Isabelle 
Published: December 2024

AimRecent research highlights the role of pericoronary adipose tissue (PCAT) in coronary artery disease (CAD) development. PCAT has been recognized as a metabolically active tissue involved in local inflammation and oxidative stress, potentially impacting CAD initiation and progression. Radiomics texture analysis shows promising results to better understand the link between PCAT quality and CAD risk. Photon-counting CT (PCCT) offers improved feature stability and holds the potential for advancing radiomics analysis in CAD research.MethodsIn this retrospective, single-center, ethic committee-approved study, PCAT of the left descending artery (LAD) and right coronary artery (RCA) was manually segmented and radiomic features were extracted using pyradiomics. The study population consisted of one group of patients with CAD and plaques exclusively located in the left coronary artery and another group without CAD. Mean and standard deviation were calculated using R Statistics. Random forest feature selection was performed to identify differentiating features between the four sets CAD-LAD, CAD-RCA, non-CAD-LAD and non-CAD-RCA.Results36 patients were enrolled in this study (16 female, mean age 56 years). The feature “original_glszm_GrayLevelNonUniformity” measuring the gray-level variability was identified as the most potent differentiator between CAD-LAD and non-CAD-LAD, as well as CAD-RCA and non-CAD-RCA with the greatest differentiating capability for the LAD comparison. The feature showed little differentiating power between CAD-LAD and CAD-RCA and virtually none between non-CAD-LAD and non-CAD-RCA. The mean values were consistently lower in LAD-PCAT and exhibited patient-specific reductions in CAD patients (155.16 for CAD-LAD, 163.21 for non-CAD-LAD, 189.13 for CAD-RCA and 215.40 for non-CAD-RCA).ConclusionRadiomics analysis revealed differences in PCAT texture of patients with and without CAD with a potentially more homogeneous pattern in CAD-affected patients. These changes related to plaques in the left coronary artery also seemed to occur in the unaffected RCA-PCAT, although to a slightly lesser extent.
Exploring the impact of deubiquitination on melanoma prognosis through single-cell RNA sequencing
Authors: Peng Su , Xie Jiaheng , He Xiaohu 
Published: December 2024

BackgroundCutaneous melanoma, characterized by the malignant proliferation of melanocytes, exhibits high invasiveness and metastatic potential. Thus, identifying novel prognostic biomarkers and therapeutic targets is essential.MethodsWe utilized single-cell RNA sequencing data (GSE215120) from the Gene Expression Omnibus (GEO) database, preprocessing it with the Seurat package. Dimensionality reduction and clustering were executed through Principal Component Analysis (PCA) and Uniform Manifold Approximation and Projection (UMAP). Cell types were annotated based on known marker genes, and the AUCell algorithm assessed the enrichment of deubiquitination-related genes. Cells were categorized into DUB_high and DUB_low groups based on AUCell scores, followed by differential expression analysis. Importantly, we constructed a robust prognostic model utilizing various genes, which was evaluated in the TCGA cohort and an external validation cohort.ResultsOur prognostic model, developed using Random Survival Forest (RSF) and Ridge Regression methods, demonstrated excellent predictive performance, evidenced by high C-index and AUC values across multiple cohorts. Furthermore, analyses of immune cell infiltration and tumor microenvironment scores revealed significant differences in immune cell distribution and microenvironment characteristics between high-risk and low-risk groups. Functional experiments indicated that TBC1D16 significantly impacts the migration and proliferation of melanoma cells.ConclusionThis study highlights the critical role of deubiquitination in melanoma and presents a novel prognostic model that effectively stratifies patient risk. The model’s strong predictive ability enhances clinical decision-making and provides a framework for future studies on the therapeutic potential of deubiquitination mechanisms in melanoma progression. Further validation and exploration of this model’s applicability in clinical settings are warranted.
Common diagnostic biomarkers and molecular mechanisms of Helicobacter pylori infection and inflammatory bowel disease
Authors: Zhang Minglin , Liu Tong , Luo Lijun , Zhang Yi , Chen Qijiao , Wang Fen , Xie Yuxin 
Published: December 2024

BackgroundHelicobacter pylori (H. pylori) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of H. pylori in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between H. pylori and IBD.MethodsThe following matrix data were downloaded from the GEO database: H. pylori-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein−protein interaction (PPI) network of DEGs was constructed via the STRING database. Cytoscape software, through the CytoHubba plugin, filters the PPI subnetwork and identifies Hub genes. Validation of the Hub genes was performed in the validation set. Immune analysis was conducted via the CIBERSORT algorithm. Transcription factor interaction and small molecule drug analyses of the Hub genes were also performed.ResultsUsing the GSE233973 and GSE3365 datasets, 151 differentially expressed genes (DEGs) were identified. GO enrichment analysis revealed involvement in leukocyte migration and chemotaxis, response to lipopolysaccharides, response to biostimulatory stimuli, and regulation of interleukin-8 (IL-8) production. Ten Hub genes (TLR4, IL10, CXCL8, IL1B, TLR2, CXCR2, CCL2, IL6, CCR1 and MMP-9) were identified via the PPI network and Cytoscape software. Enrichment analysis of the Hub genes focused on the lipopolysaccharide response, bacterial molecular response, biostimulatory response and leukocyte movement. Validation using the GSE27411 and GSE179285 datasets revealed that MMP-9 was significantly upregulated in both the H. pylori and IBD groups. The CIBERSORT algorithm revealed immune infiltration differences between the control and disease groups of IBD patients. Additionally, the CMap database identified the top 11 small molecule compounds across 10 cell types, including TPCA-1, AS-703026 and memantine, etc.ConclusionOur study revealed the co-pathogenic mechanism between H. pylori and IBD and identified 10 Hub genes related to cellular immune regulation and signal transduction. The expression of MMP-9 is significantly upregulated in both H. pylori infection and IBD. This study provides a new perspective for exploring the prevention and treatment of H. pylori infection and IBD.
Association between herpes zoster and Parkinson’s disease and dementia: a systematic review and meta-analysis
Authors: Zhang Yanfeng , Liu Weiping , Xu Yang 
Published: December 2024

ObjectivesThis meta-analysis investigated the relationship between herpes zoster and the risk of dementia or Parkinson’s disease by analyzing published clinical studies.MethodsWe systematically searched PubMed, Cochrane, Embase, and Web of Science Core Collection databases on April 25, 2024. Hazard ratios (HR) were used for statistical analyses. Random-effects models were applied, and heterogeneity was assessed using the I2 statistic.ResultsHerpes zoster was associated with a non-significant trend toward increased dementia risk (HR = 1.11, 95% CI 0.99–1.24, p = 0.07) but significantly increased Parkinson’s disease risk (HR = 1.15, 95% CI 1.03–1.30, p = 0.02). Subgroup analyses revealed that herpes zoster significantly elevated the risk of the prospective study subgroup (HR = 1.08, 95% CI 1.02–1.13, p = 0.004) and vascular dementia subgroup (HR = 1.17, 95% CI 1.00–1.37, p = 0.05). Significant heterogeneity was observed for both outcomes (dementia: I2 = 98%, p &lt; 0.00001; Parkinson’s disease: I2 = 94%, p &lt; 0.00001).ConclusionHerpes zoster raises the risk of Parkinson’s disease and vascular dementia, with a potential causal link to dementia. Early vaccination against herpes zoster is recommended over post-infection antiviral treatment to mitigate risks.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/ and our registration number is CRD42024555620.
Integrated solutions for sustainable fall prevention in primary care: a pragmatic hybrid-type 2 mixed methods implementation and effectiveness study
Authors: Clemson Lindy , Mackenzie Lynette , Lovarini Meryl , Roberts Christopher , Poulos Roslyn , Sherrington Catherine , Tan Amy C. W. , Simpson Judy , Pond Constance Dimity , Pit Sabrina , Tiedemann Anne , Lovitt Lorraine , Hilmer Sarah N. 
Published: December 2024

The iSOLVE implementation project established and evaluated integrated processes and pathways, including a decision-making tool and educational interventions for general medical practitioners (GPs) and the upskilling of allied health professionals (AHPs). The study used a mixed-methods (parallel) design comprising surveys, qualitative methodologies, and an embedded cluster randomized controlled trial (RCT). Sampling was conducted within a Primary Health Network (PHN) geographic area in Sydney, Australia. AHP workshops (n = 367 attendees) covered six evidence-based interventions, resulting in increased confidence (p &lt; 0.001) and numerous enhancements in fall prevention delivery. Among GPs, 75 were recruited from 27 practices. GPs in the experimental group were more likely to engage in fall prevention activities, including risk assessments, medication reviews, and providing advice, compared to the control group (p = 0.002). They were also more likely to refer patients to AHPs at 3 months (p = 0.002); however, this effect was not significant at 12 months (p = 0.13), as referral behaviors increased in the control group over time. Responses to free-text questions of practice change highlighted differences, with the experimental group reporting a more proactive and comprehensive approach to fall prevention. In a subset of GP patients (n = 560), no significant effect was observed in reducing the rate of falls (IRR = 0.96). The pragmatic nature of the project and potential contamination across multiple elements likely influenced this outcome. However, an area-wide survey of GPs (n = 562) revealed an increase in fall prevention referrals to AHPs over 5 years, from 70 to 82% (p = 0.028). Our findings highlight the importance of equipping GPs with tools and strategies to adopt a proactive approach to fall prevention among older patients. AHPs play a crucial role in this effort, and fostering relationships and connectivity across primary care networks is essential to maximizing the impact of fall prevention initiatives.Clinical trial registrationAustralian New Zealand Clinial Trials Registry, ACTRN12615000401550, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368286.
ANALISIS SENYAWA FITOKIMIA DAUN Moringa oleifera DARI KAWASAN GEOTERMAL ACEH BESAR SEBAGAI KANDIDAT ANTIINFLAMASI
Authors: Santi Tahara Dilla , Candra Aditya 
Published: December 2024

Indonesia is home to a diversity of herbal plants, particularly in Aceh. Moringa oleifera is traditional medicinal plant utilized by locals in the geothermal area Aceh Besar, recognized for its anti-inflammatory properties. However, the bioactive compounds in M. oleifera leaves sourced from Ie Seum have not been documented, making it challenging to explain the roles of the compounds scientifically to anti-inflammatory factors. This research aimed to identify the phytochemical compounds in the ethanol extract of M. oleifera leaves (referred to as EDM) and analyze the physicochemical characteristics of the soil in the geothermal area. This study used a qualitative design to identify EDM compounds with GC-MS and soil physicochemistry. The identification of EDM compounds is conducted through gas chromatography with mass spectrometry (GC-MS). The physicochemical properties of the soil are assessed by examining its texture, pH, organic carbon content, total nitrogen, exchangeable cations, and phosphorus. Sample collection on topsoil (0-20 cm) with an area of ​​100cmx100cm on one land where M. oleifera plants grow in Ie Seum area in September 2024. A soil sample of 500g was using several methods, namely the hydrometermethod, pH meter, Walkey and Black, ammonium acetate 1M pH 7, Kjeldahl, KCl 1N, Bray 1, HCl 25%, and DTPA extraction. The soil test result showed classified as silty clay. The results GC-MS indicated the presence 11 metabolites, including linolenic acid, phytol, 9,12,15-octadecatrienoic acid ethyl ester, hexadecanoic acid, neophytadiene, gamma-tocopherol, vitamin E, squalene, icosane, and beta-pinene. EDM from the Ie Seum contains compounds that are beneficial in anti-inflammatory.
On the asymptotic values of meromorphic functions in the

n

-fold punctured plane
Authors: Arias Arturo Fernández 
Published: December 2024

UDC 517.5
We present some results on the asymptotic paths and asymptotic values for meromorphic functions in the

n

-fold extended punctured plane

ℂ
^

\

{

p
1

,
…
,

p
n

}

.

These results extend some classical results obtained for analytic and meromorphic functions in the complex plane

ℂ
.

In particular, in this more general setting, we give a version of F. Iversen's result on the existence of asymptotic values for entire functions in the plane. We also obtain a bound for the number of isolated directly critical singularities of a meromorphic function of finite order

k

and a finite number of poles.
Potentials for solenoidal fields using the three-dimensional

φ

-harmonic cyclic algebra
Authors: Díaz-Marín Homero G. , López-González Elifalet , Osuna Osvaldo 
Published: December 2024

UDC 517.5
Given a PDE, in [E. López-González, E. A. Martínez-García, R.~Torres-Córdoba, <em>Chaos, Solitons and Fractals,</em> <strong>73</strong>, Article 113757 (2023)], the authors proposed a method for the construction of solutions by considering an associative real algebra

𝔸

and a suitable affine vector field

φ

with respect to which the components of all functions

ℒ
∘
φ

are solutions, where

ℒ

is differentiable in a sense of Lorch with respect to

𝔸
.

If we consider the 3D cyclic algebra and a suitable 3D affine map

φ
,

then we get families of solutions for the Laplace equation with three independent variables.
Degenerations of 3-dimensional nilpotent associative algebras over an algebraically closed field
Authors: Ivanova N. M. , Pallikaros C. A. 
Published: December 2024

UDC 512.5+514
We determine the complete degeneration picture inside the variety of nilpotent associative algebras of dimension three over an algebraically closed field. As compared with the discussion in [N. M. Ivanova, C. A. Pallikaros, Adv. Group Theory and Appl., <strong>18</strong>, 41-79 (2024)], for some arguments in the present article, it is necessary to develop alternative techniques, which are now valid over an arbitrary algebraically closed field. There is a dichotomy of cases concerning the obtained results corresponding to the cases where the characteristic of the field is

2

or not.
Longévité d’un canon : carnation et musculature dans les images de Serge Lifar
Authors: Ehrbar Lorena 
Published: December 2024

Par l’examen des représentations photographiques et cinématographiques de Serge Lifar, et de leur diffusion, le présent article vise à éclairer certains ressorts visuels de la fascination exercée par le danseur, de ses débuts aux Ballets russes en 1923 jusqu’à la fin de son activité à l’Opéra de Paris en 1958. En mettant en scène sa carnation et sa musculature, ces images construisent un canon corporel à la fois inaccessible et profondément ancré dans son époque, performatif dans la durée grâce à sa diffusion dans les médias, dont l’essor est alors considérable. Le modèle représenté par Serge Lifar, situé par rapport à d’autres corps canoniques de son temps, tire son efficacité d’une perpétuelle négociation entre l’incarnation de fantasmes d’un ailleurs exotique et celle d’un idéal de la modernité blanche et désirable inspirée de l’antique.
Hepatitis A and hepatitis E virus co-infection in children with acute viral hepatitis, associated risk factors and clinical outcome in a tertiary care hospital: A prospective observational study
Authors: Mehta Anita , Yadav Ajeet Kumar , Kumar Ankur , Singh Amresh Kumar , Dwivedi Gaurav Raj 
Published: December 2024

Introduction: Acute viral hepatitis (AVH) is mostly caused by hepatitis A virus (HAV) and hepatitis E virus (HEV). Hepatitis B virus, on the other hand, is a major cause of chronic liver disease in children and adolescents. Objectives: To determine the seroprevalence and clinical outcomes of HAV and HEV in children of different age groups in a tertiary care hospital in Eastern Uttar Pradesh, India.Method: During the study period, 382 clinically suspected cases of acute hepatitis were examined. Data included demographic information; and clinical history of illness specifically linked to the hepato-biliary system.Results: A total of 382 samples was screened for AVH of which 58 (15.1%) were HAV positive, 21 (5.4%) were HEV positive and 12 (3.1%) were positive for both anti‑HAV and anti‑HEV antibodies indicating HAV‑HEV co‑infection. There was also significant co-infection between hepatitis A and E. Male children (54%) were more prone to all kinds of viral hepatitis than female children (46%), with the most common age group being 0-5 years in HAV cases and 11-15 years in HEV cases. Icterus was the most prevalent clinical sign in the hepatitis profile, followed by fever, hepatomegaly and nausea.Conclusions: In this tertiary care hospital in Eastern Uttar Pradesh, India, the most frequent viral hepatitis infection in children was hepatitis A, followed by HEV. There was significant co-infection between hepatitis A and E.
Urinary lipoarabinomannan for diagnosis of Tuberculosis in an HIV-negative population: A scoping review
Authors: Hirachund Omishka , Pillay Somasundram 
Published: December 2024

Background: Tuberculosis (TB) remains a leading cause of mortality in low-resource settings and poses a diagnostic challenge in human immunodeficiency virus (HIV)-negative populations because of limitations in traditional diagnostic methods such as sputum smear microscopy (SSM) and sputum Xpert Ultra. There is a lack of effective, non-invasive diagnostic options for TB diagnosis in HIV-negative populations. This scoping review explores the potential of urinary lipoarabinomannan (ULAM) as a point-of-care diagnostic tool for Mycobacterium tuberculosis (MTB) in HIV-negative individuals.Aim: To evaluate the diagnostic performance of ULAM in detecting TB among HIV-negative populations and assess its feasibility as a rapid, non-invasive diagnostic method.Method: A systematic search was conducted across PubMed, Google Scholar and Scopus. Articles were selected based on relevance to the topic.Results: The search yielded 210 articles, with 11 meeting our inclusion criteria. These studies reported varying diagnostic performance metrics for ULAM: sensitivity ranged from 10.0% to 66.7% and specificity from 90.0% to 98.1% among different assays. Notably, the studies demonstrated that the novel assays such as Electrochemiluminescence LAM and the second-generation FujiLAM showed higher sensitivities of 66.7% and 53.2%, respectively. Despite these advancements, the overall effectiveness of ULAM in HIV-negative populations remains limited, with standard assays exhibiting sensitivities as low as 10.0%.Conclusion: While ULAM holds potential as a diagnostic tool in HIV-associated TB, its application in HIV-negative populations is constrained by low sensitivity of the currently available assays.Contribution: The development and validation of high-sensitivity assays are crucial for broadening the utility of ULAM in these populations.
PENGARUH PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE GROUP INVESTIGATION (GI) TERHADAP HASIL BELAJARIPS SISWA KELAS VII DI SMP NEGERI 03 SOLOK SELATAN TAHUN AJARAN 2023/2024
Authors: Salsabillah Miranti Putri , Rahayu Sri , Wijaya Wibi 
Published: December 2024

Penelitian ini di latar belakangi oleh metode pembelajaran yang dilakukan Adapun tujuan dalam penelitian ini adalah untuk meningkatkan hasil belajar siswa IPS kelas VII SMPN 03 Solok Selatan tahun ajaran 2023/2024. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif dengan tipe eksperimen, Berdasarkan hasil penelitian Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Group Investigation (GI) Terhadap Hasil Belajar IPS Siswa kelas VII Di SMPN 03 Solok Selatan Tahun Ajaran 2023/2024 terdapat rata-rata nilai posttest pada kelas eksperimen adalah 81,78 dengan jumlah siswa sebanyak 23 orang dan rata-rata kelas kontrol 66,69 dengan jumlah siswa 9 orang. Berdasarkan hasil uji t penerapan model pembelajaran Group Investigation (GI) terhadap hasil belajar siswa dimana 0.0000.05. Artinya hipotesis dalam penelitian ini di terima karena memiliki pengaruh antara model pembelajaran dengan hasil belajar.
ANALISIS MAKNA DALAM LIRIK LAGU WONDERLAND INDONESIA KARYA ALFFY REF
Authors: Tirsa Aprima , Mastiah Mastiah , Wulandari Enis 
Published: December 2024

Abstrack: This study discusses the lyrics of the song "Wonderland Indonesia" by Alffy Ref, which reflects the love and pride of the beauty and richness of Indonesian culture. The background of the study shows that literary works, including song lyrics, have a variety of interesting language styles and can be studied to understand deeper meanings. The research method used is descriptive qualitative with a structural approach, focusing on the analysis of language styles in the lyrics. The results of the analysis show that the song lyrics express a sense of nationalism through the depiction of cultural diversity and natural wealth of Indonesia. The phrases in the lyrics emphasize a deep love for the homeland, as well as a commitment to serve the country. By combining elements of traditional and modern culture, this song not only functions as entertainment, but also as a medium to foster a sense of nationalism and solidarity among the younger generation. This study is expected to contribute to the understanding of the power of literature in arousing the spirit of nationalismKeywote : Analysis of meaning, song lyrics, wonderland Indonesia Abstrak : Penelitian ini membahas lirik lagu "Wonderland Indonesia" karya Alffy Ref, yang mencerminkan kecintaan dan kebanggaan terhadap keindahan serta kekayaan budaya Indonesia. Latar belakang penelitian menunjukkan bahwa karya sastra, termasuk lirik lagu, memiliki ragam gaya bahasa yang menarik dan dapat dipelajari untuk memahami makna yang lebih dalam. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan struktural, fokus pada analisis gaya bahasa dalam lirik. Hasil analisis menunjukkan bahwa lirik lagu mengekspresikan rasa nasionalisme melalui penggambaran keragaman budaya dan kekayaan alam Indonesia. Frasa-frasa dalam lirik menekankan cinta yang mendalam terhadap tanah air, serta komitmen untuk mengabdi kepada negara. Dengan menggabungkan elemen budaya tradisional dan modern, lagu ini tidak hanya berfungsi sebagai hiburan, tetapi juga sebagai media untuk menumbuhkan rasa kebangsaan dan solidaritas di antara generasi muda. Penelitian ini diharapkan dapat memberikan kontribusi pada pemahaman tentang kekuatan sastra dalam membangkitkan semangat nasionalisme.Kata kunci : Analisis makna, lirik lagu, wonderland Indonesia