bluuebunny/crossref_metadata_2025_split huggingface dataset:
Science for tomorrow’s neurosurgery: insights on establishing a neurosurgery patient group focused on developing novel intra-operative imaging techniques
Authors: MacCormac Oscar , Elliot Matthew , Whittaker Lisa , Bahl Anisha , Ségaud Silvère , Plowright Andrew J. , Winslade Shannon , Taylor-Gee Alice , Spencer Bella , Vercauteren Tom , Shapey Jonathan 
Published: October 2024

Abstract
Background
Incorporating patient and public involvement (PPI) in research is crucial for ensuring the relevance and success of studies, yet it remains significantly underutilised in surgical research.

Main body
This commentary presents insights from our neurosurgical research team’s experience with establishing and working with a PPI group called “Science for Tomorrow’s Neurosurgery” on research regarding novel intra-operative optical imaging techniques. Through collaboration with patient-focused charities, we have successfully incorporated patient perspectives into our work at each stage of the research pipeline, whilst adhering to core PPI principles, such as reciprocal relationships, co-learning, partnerships, and transparency.

Conclusion
We highlight the specific value added to our work in terms of participant recruitment, research ethics and results dissemination.
Jack of all trades, master of one: domain-specific and domain-general contributions to perceptual expertise in visual comparison
Authors: Growns Bethany , Dunn James D. , Helm Rebecca K. , Towler Alice , Mattijssen Erwin J. A. T. , Martire Kristy A. 
Published: October 2024

AbstractPerceptual expertise is typically domain-specific and rarely generalises beyond an expert’s domain of experience. Forensic feature-comparison examiners outperform the norm in domain-specific visual comparison, but emerging research suggests that they show advantages on other similar tasks outside their domain of expertise. For example, fingerprint examiners not only outperform novices in fingerprint comparison, but also in face comparison. Yet, the extent to which their skills generalise is poorly understood. In this study, we investigated the generalisability of perceptual expertise amongst forensic examiners by comparing their performance to novices and other examiners within and outside their area of expertise. We recruited 85 experts from three forensic disciplines (face, fingerprint, and firearms) and asked them to complete four different visual comparison tasks: faces, fingerprints, firearms, and novel-objects. Examiners displayed domain-specific expertise: they outperformed novices and other examiners within their domain of visual comparison expertise. Yet, some of their skill also generalised: examiners also outperformed novices outside their area of expertise. However, while individual differences in examiners’ performance within their domain of experience were associated with their performance in a novel comparison task, they were not related to their performance on tasks outside their expert domain. These results provide key insight into the domain-specific and domain-general contributions of forensic examiners’ perceptual expertise. Forensic expertise lends some generalisable skill to other visual comparison tasks, but best performance is still seen within examiners’ domain of expertise.
Characterization and pathogenicity of newly recorded Clonostachys rogersoniana against woolly apple aphid (Eriosoma lanigerum Hausmann) from India
Authors: Kumar Dinesh , Kumari Neelam , Mhatre Priyank Hanuman , Pal Dharam , Naga Kailash Chandra , Watpade Santosh 
Published: October 2024

Abstract
Background
Woolly apple aphid (Eriosoma lanigerum Hausmann) (Homoptera: Aphididae) infests the aerial and edaphic portions of apple trees. It is responsible for the serious qualitative and quantitative reduction in apple fruits. This pest is mainly managed by chemical insecticides, so this present study was focused on the isolation of native entomopathogenic fungi (EPF), studying their growth characteristics and virulence against woolly apple aphids.

Results
Clonostachys rogersoniana, as an EPF from an insect cadaver, was isolated and characterized, using morphological, microscopic, and molecular techniques. To the best of our knowledge, this is the first report of the occurrence of this fungus from India and it is named “C. rogersoniana isolate PUSACR01”. The radial growth and conidial yield of this isolate were excellent on PDAY among ten different culture media, whereas the relative growth rate and conidial germination were good on PDA and CA. The isolated fungus showed 85 and 86.67% mortality rates in adult females of the woolly apple aphid on day 11 at a concentration of 1.0 × 107 and 1.0 × 108 conidia ml−1, respectively. The LC50 values determined by probit regression analysis for days 7, 9, and 11 were 1.12 × 107, 2.52 × 106, and 4.74 × 105 conidia ml−1, respectively, while LT50 for concentrations of 1.0 × 105, 1.0 × 106, 1.0 × 107, and 1.0 × 108 conidia ml−1 were 18.73, 9.39, 6.71, and 5.03 days, respectively.

Conclusion
Based on the present study, C. rogersoniana would be considered a good biological control agent against the woolly apple aphid in apple orchards.
Proteomic identification of apoplastic proteins from rice, wheat, and barley after Magnaporthe oryzae infection
Authors: Wang Jiyang , Diaz Josue , Hua Kangyu , Bellizzi Maria , Qi Linlu , Zhu Lin , Qu Menghan , Wang Guo-Liang 
Published: October 2024

AbstractThe fungal pathogen Magnaporthe oryzae causes devastating blast disease in various cereals, including rice (Oryza sativa), wheat (Triticum aestivum), maize (Zea mays), and barley (Hordeum vulgare). Despite previous reports on fungal host specificity, the mechanisms underlying differential host infection strategies remain unclear. This study aimed to identify differentially abundant proteins (DAPs) in the apoplast of rice, barley, and wheat following infection with two M. oryzae pathovars using liquid chromatography-tandem mass spectrometry (LC–MS/MS). LC–MS/MS analysis revealed an enrichment of both M. oryzae and host proteins in the apoplast during the compatible reaction compared to the incompatible reaction. DAPs from M. oryzae involved in the host interaction included secreted extracellular enzymes (e.g., hydrolases), which were significantly increased in the M. oryzae Oryzae (MoO)-infected rice apoplast. Among host proteins, the proportion of protein-modifying enzymes increased in the M. oryzae Triticum (MoT)-infected rice and MoO-infected wheat apoplastic fluids, particularly rice glycosidases, peroxidases, and serine proteases, as well as wheat serine proteases. Furthermore, DAPs from MoL-infected rice were enriched in carbohydrate metabolism, suggesting that carbohydrate metabolism-related proteins may play a vital role in rice resistance to MoL. Additionally, protein-modifying and cytoskeletal proteins, as well as stress-responsive proteins, were enriched in the MoO-infected wheat apoplastic fluid. Finally, DAPs from both MoO- and MoL-infected barley were enriched in hydrogen peroxide catabolism, suggesting that peroxidases may be vital for barley resistance to M. oryzae. The identification of DAPs from both M. oryzae strains and the three host plants offers valuable insights into the host specificity mechanisms of M. oryzae in cereal crops.
The role of AGAP2-AS1, DLEU2, HMBOX1_1, and UGDH-AS1 in the progression of esophageal squamous cell carcinoma
Authors: Talebi Samaneh , Kargar Mohammad , Jafarinia Mojtaba , Gholamin Mehran 
Published: October 2024

Abstract
Background
Long noncoding RNAs (lncRNAs) have been recognized as viable prognostic and therapeutic indicators for numerous human malignancies. Nonetheless, the operational roles and fundamental mechanisms of important lncRNAs that impact esophageal squamous cell carcinoma (ESCC) remain predominantly obscure. Recently, lncRNAs have been identified to exert regulatory influence on epithelial-mesenchymal transition (EMT) via intricate interplay with EMT-associated transcription factors (TFs) and signaling pathways. The current experimental study aimed to elucidate the expression of four lncRNAs in ESCC patients and explain their potential involvement in the EMT process and the pathogenesis of ESCC.

Methods
In the study, the expression levels of lncRNAs (AGAP2-AS1, DLEU2, HMBOX1_1 (AC108449.2), and UGDH-AS1) and mRNAs (TWIST1, MMP13, and CD44S) between fifty ESCC and adjacent normal tissue samples were measured using quantitative real-time PCR.

Results
The upregulation of CD44S (36%), TWIST1 (52%), DLEU2 (58%), AGAP2-AS1 (62%), and MMP13 (74%), were indicated in ESCC samples, while the downregulation of UGDH-AS1 and HMBOX1_1 were found in 62% and 64% of patients, respectively. The expression levels of lncRNAs and EMT-related markers were found to be significantly correlated in several patient clinicopathological traits (P < 0.05), representing correlations between AGAP2-AS1, DLEU2, HMBOX1_1 (AC108449.2), and UGDH-AS1 with EMT status in ESCC.

Conclusion
Our results have unveiled that these lncRNAs, which regulate EMT, may play a crucial role in the regulatory process of EMT via the CD44S-TWIST1-MMP13 axis. Moreover, it may be assumed that lncRNAs present a promising avenue for both diagnosis and therapeutic intervention in the context of ESCC.
Exploring the impact of brucellosis on maternal and child health: transmission mechanisms, patient effects, and current trends in drug use and resistance: a scoping review
Authors: Huy Tran Xuan Ngoc 
Published: October 2024

Abstract
Background
While often unrecognized, brucellosis, a significant zoonotic disease, silently endangers the health of mothers and children worldwide. This scoping review sheds light on transmission pathways, maternal–fetal consequences, and treatment hurdles, specifically considering maternal and child health concerns.

Method
To comprehensively grasp brucellosis in mothers and children, we systematically scoured electronic databases (DOAJ, Google Scholar, PubMed, and Semantic Scholar) for studies published after 2005. Our search included experimental studies (both randomized controlled clinical trials and quasi-experimental), analytical observations, descriptive reports, qualitative papers, and existing systematic reviews. All retrieved data were then charted and processed following Arksey and O'Malley's established framework for scoping reviews.

Result
Twenty-five studies spanning varied regions and methodologies met inclusion criteria. Key findings demonstrate that zoonotic brucellosis acquisition from livestock exposures among vulnerable maternal groups accounts for up to 70% of cases. Vertical transmission from mother to child during pregnancy, delivery, or breastfeeding was reported in 15–20% of cases. Substantial risks of miscarriage (25%), preterm birth (20%), hepatosplenomegaly (10%), febrile illness (30%), and possible long-term complications were documented. Treatment success rates using combination antibiotic therapy were reported to be as high as 98%, though emerging antibiotic resistance patterns challenge effective treatment, with 25% of Brucella isolates resistant to rifampin and 51% resistant to both trimethoprim-sulfamethoxazole and streptomycin.

Conclusion
This review reveals the alarming yet hidden toll brucellosis takes on maternal–fetal pairs and breastfeeding. In regions battling this endemic disease, tailored education, upgraded diagnostic tools, prompt antibiotic therapy, responsible antimicrobial stewardship, and One Health collaborations offer crucial pathways to shield mothers and children from its harmful consequences. Continued research will pave the way for even better solutions to alleviate this complex zoonosis, particularly for vulnerable populations.
Total resection via right mini-thoracotomy for left atrial myxoma in juvenile Carney complex: a case report
Authors: Matsunaga Kazumasa , Ikenaga Shigeru 
Published: October 2024

Abstract
Background
Carney complex is a rare syndrome characterized by skin pigmentation, endocrine disorders, and myxomas. It is particularly notorious for its tendency to exhibit aggressive cardiac myxomas. Herein, we present a case of a juvenile female patient diagnosed with Carney complex who underwent a right lateral mini-thoracotomy.

Case presentation
A 13-year-old girl presented with sudden-onset left hemiplegia and dysarthria. Magnetic resonance imaging revealed multiple areas of restricted diffusion. Echocardiography identified a tumor in the left atrium, suspected to be related to Carney complex based on her medical history and physical examination findings. Surgery was performed via right lateral mini-thoracotomy, which minimized the risk of embolism and ensured a cosmetically favorable outcome. The left atrial wall defect was repaired with autologous pericardium. At 3 years postoperatively, follow-up echocardiography indicated no tumor recurrence and normal cardiac function.

Conclusions
Ongoing follow-ups are essential due to the aggressive nature of the Carney complex and its high recurrence rates. Right lateral mini-thoracotomy offers the advantage of avoiding re-sternotomy and minimizing adhesion dissection, making it the optimal choice for this case.
Determining structural sites of the IGPD protein family from patterns in property-based correlation matrices
Authors: Kumari Rakhi , Deo Nivedita 
Published: October 2024

Abstract
In this work, we use the statistical approach of random matrix and network theory to tackle the problem of identifying the important motifs responsible for the crucial functioning of the protein family. This addresses directly the question of patterns of interaction between amino acid residues (based on properties) in proteins that contribute to protein function. We use the mathematical tools of inverse participation ratio and Shannon entropy to determine the locations of the important groups of correlated amino acid positions, which gives us the structural sites of the IGPD protein. These tools isolate the smallest eigenvalues/outliers corresponding to eigenmodes as the most localized which give the crucial sites for the structure and function of the family. We also create the threshold network of the IGPD protein and find that at a certain threshold, similar sites emerge from the network analysis which in addition gives us the strongest connected sites. This strengthens our method of finding the structural and functional sites. As a bonus we find that these important sites also match with experiments.
Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV Study
Authors: Boughanem Hatim , de Larriva Antonio Pablo Arenas , Camargo Antonio , Torres-Peña José D , Ojeda-Rodriguez Ana , Alcala-Diaz Juan F , Romero-Cabrera Juan L , Rangel-Zuñiga Oriol Alberto , Rodríguez-Cantalejo Fernando , Soehnlein Oliver , Macias-Gonzalez Manuel , Tinahones Francisco J , Perez-Martinez Pablo , Delgado-Lista Javier , López-Miranda José 
Published: October 2024

Abstract

Context
Numerous studies have reported an association between neutrophils and type 2 diabetes mellitus (T2DM), although this relationship remains unclear.

Objective
To investigate the interaction of neutrophils and a dietary intervention on T2DM incidence after 60 months of follow-up.

Methods
A comprehensive analysis was conducted on the framework of the CORDIOPREV study, which included 462 patients without T2DM at the beginning of the study, randomly assigned to either a Mediterranean or a low-fat diet; 107 developed T2DM. Absolute neutrophil counts and neutrophil-related ratios were measured.

Results
Kaplan-Meier curves showed that the lowest tertile of basal neutrophils was associated with a reduced likelihood of T2DM incidence when compared to the middle (hazard ratio [HR] = 0.499 [95% CI, 0.287-0.866]) and the highest tertiles (HR = 0.442 [95% CI, 0.255-0.768]) in the overall population, after adjusting for clinical variables. This association only remained significant in patients who followed a Mediterranean diet when comparing the lowest to the middle (HR = 0.423 [95% CI, 0.213-0.842]) and the highest tertiles (HR = 0.371 [95% CI, 0.182-0.762]). The predictive capacity yielded an AUC of 0.711 (95% CI, 0.652-0.769), with neutrophils being the most important variable in the in the model. Decrease in neutrophils over the 60 months was associated with increased insulin sensitivity index (R = −0.31; P = .019), particularly in patients who followed the Mediterranean diet.

Conclusion
These findings suggest that monitoring neutrophils can help prevent the development of T2DM, as a reduction in neutrophil counts could be associated with improved insulin sensitivity. Following a Mediterranean diet might be a potential strategy to reduce the incidence of T2DM by lowering neutrophil levels. Further research is necessary to gain a deeper understanding regarding this mechanism.
Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice
Authors: von Voss Liv , Arora Tulika , Assis Juliana , Kuentzel Katharina B , Arfelt Kristine N , Nøhr Mark K , Grevengoed Trisha J , Arumugam Manimozhiyan , Mandrup-Poulsen Thomas , Rosenkilde Mette M 
Published: October 2024

Abstract

Context
Excessive eating and intake of a Western diet negatively affect the intestinal immune system, resulting in compromised glucose homeostasis and lower gut bacterial diversity. The G protein–coupled receptor GPR183 regulates immune cell migration and intestinal immune response and has been associated with tuberculosis, type 1 diabetes, and inflammatory bowel diseases.

Objective
We hypothesized that with these implications, GPR183 has an important immunometabolic role and investigated this using a global Gpr183 knockout mouse model.

Methods
Wild-type (WT) and Gpr183-deficient (Gpr183–/–) mice were fed a high-fat, high-sucrose diet (HFSD) for 15 weeks. We investigated changes in weight, body composition, fecal immunoglobulin A (IgA) levels, fecal microbiome, and glucose tolerance before and after the diet. Macrophage infiltration into visceral fat was determined by flow cytometry, and hepatic gene expression was measured.

Results
A sexual dimorphism was discovered, whereby female Gpr183–/– mice showed adverse metabolic outcomes compared to WT counterparts with inferior glucose tolerance, lower fecal IgA levels, and increased macrophage infiltration in visceral fat. In contrast, male Gpr183–/– mice had significantly lower fasting blood glucose after diet than male WT mice. Liver gene expression showed reduced inflammation and macrophage markers in Gpr183–/– livers, regardless of sex, while the pancreatic islet area did not differ between the groups. No conclusive differences were found after microbiome sequencing.

Conclusion
Gpr183 maintains metabolic homeostasis in female but not in male mice independent of diet. If confirmed in humans, future therapy targeting GPR183 should consider this sexual dimorphism.
Optimized Noise Suppression for Quantum Circuits
Authors: Wagner Friedrich , Egger Daniel J. , Liers Frauke 
Published: October 2024

Quantum computation promises to advance a wide range of computational tasks. However, current quantum hardware suffers from noise and is too small for error correction. Thus, accurately utilizing noisy quantum computers strongly relies on noise characterization, mitigation, and suppression. Crucially, these methods must also be efficient in terms of their classical and quantum overhead. Here, we efficiently characterize and mitigate crosstalk noise, which is a severe error source in, for example, cross-resonance based superconducting quantum processors. For crosstalk characterization, we develop a simplified measurement experiment. Furthermore, we analyze the problem of optimal experiment scheduling and solve it for common hardware architectures. After characterization, we mitigate noise in quantum circuits by a noise-aware qubit routing algorithm. Our integer programming algorithm extends previous work on optimized qubit routing by swap insertion. We incorporate the measured crosstalk errors in addition to other, more easily accessible noise data in the objective function. Furthermore, we strengthen the underlying integer linear model by proving a convex hull result about an associated class of polytopes, which has applications beyond this work. We evaluate the proposed method by characterizing crosstalk noise for two chips with up to 127 qubits and leverage the resulting data to improve the approximation ratio of the Quantum Approximate Optimization Algorithm by up to 10% compared with other established noise-aware routing methods. Our work clearly demonstrates the gains of including noise data when mapping abstract quantum circuits to hardware native ones. History: Accepted by Giacomo Nannicini, Area Editor for Quantum Computing and Operations Research. Accepted for Special Issue on Quantum Computing. Funding: This work was supported by Bavarian state government; Bayerische Staatsministerium für Wirtschaft, Landesentwicklung und Energie. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0551 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0551 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
The Fairtrade academic collaboration model: Putting in place the building blocks of collaboration between Fairtrade and academics
Authors: Schneider Elisabeth , Mendoza Arisbe , Hastings Jesse 
Published: October 2024

Abstract
Fairtrade International and its member organizations have long been involved in producing research, so to better understand operating structures and environments, to identify the causal mechanisms in the Fairtrade Theory of Change results chain, and to assess Fairtrade’s impact. Much of this research has been commissioned. However, Fairtrade increasingly also looks to collaborate with academic institutions in producing research so as to more effectively link to academic networks and areas of expertise. This article summarizes Fairtrade’s academic collaboration model and elaborates on (i) what are the relevant research topics in which Fairtrade is interested, (ii) what a successful collaboration between Fairtrade and academic researchers should entail and (iii) what a collaboration with Fairtrade offers academic researchers. Fairtrade encourages academics to reach out to Fairtrade International with questions, comments and ideas around collaborations via academicpartnerships@fairtrade.net.
Vanadium dioxide and a graphene-based ultra-wideband absorption and polarization conversion switchable terahertz device
Authors: Chen Wenya , Li Chao , Wang Dong , Gao Song , Wu Guozheng , Guo Shijing , Xiong Jiaran 
Published: October 2024

A multifunctional terahertz functional device based on vanadium dioxide (VO2) and graphene is proposed, which can realize ultra-wideband absorption and polarization conversion. When the VO2 is in the insulating state, the device can achieve the polarization conversion function to convert the incident wave into the corresponding cross-polarized wave. Polarization conversion ratios (PCRs) can exceed 90% in the 2.1–8 THz frequency range; in the 3–7.5 THz range, the PCR can be more than 95%. When VO2 is in the metallic state and the graphene Fermi energy is 0.9 eV, the device can realize a broadband absorption function. An absorption rate of more than 90% can be achieved over a wide frequency range of 3.3–7.7 THz. In addition, the polarization conversion device can maintain high performance in broadband polarization conversion at incident angles no greater than 40°. The absorber device also exhibits insensitivity to both incident and polarization angles. These advantages which make the proposed multifunctional terahertz functional device have a wide range of applications in the fields of terahertz imaging, sensing, communication, and so on.