bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass Spectrometry–Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers
Authors: Mundt Filip , Rajput Sandeep , Li Shunqiang , Ruggles Kelly V. , Mooradian Arshag D. , Mertins Philipp , Gillette Michael A. , Krug Karsten , Guo Zhanfang , Hoog Jeremy , Erdmann-Gilmore Petra , Primeau Tina , Huang Shixia , Edwards Dean P. , Wang Xiaowei , Wang Xuya , Kawaler Emily , Mani D.R. , Clauser Karl R. , Gao Feng , Luo Jingqin , Davies Sherri R. , Johnson Gary L. , Huang Kuan-lin , Yoon Christopher J. , Ding Li , Fenyö David , Ellis Matthew J. , Townsend R. Reid , Held Jason M. , Carr Steven A. , Ma Cynthia X. 
Published: February 2018

Abstract
Activation of PI3K signaling is frequently observed in triple-negative breast cancer (TNBC), yet PI3K inhibitors have shown limited clinical activity. To investigate intrinsic and adaptive mechanisms of resistance, we analyzed a panel of patient-derived xenograft models of TNBC with varying responsiveness to buparlisib, a pan-PI3K inhibitor. In a subset of patient-derived xenografts, resistance was associated with incomplete inhibition of PI3K signaling and upregulated MAPK/MEK signaling in response to buparlisib. Outlier phosphoproteome and kinome analyses identified novel candidates functionally important to buparlisib resistance, including NEK9 and MAP2K4. Knockdown of NEK9 or MAP2K4 reduced both baseline and feedback MAPK/MEK signaling and showed synthetic lethality with buparlisib in vitro. A complex in/del frameshift in PIK3CA decreased sensitivity to buparlisib via NEK9/MAP2K4–dependent mechanisms. In summary, our study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy.
Significance: Integrative phosphoproteogenomic analysis is used to determine intrinsic resistance mechanisms of triple-negative breast tumors to PI3K inhibition. Cancer Res; 78(10); 2732–46. ©2018 AACR.
JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non–small Cell Lung Cancers
Authors: Pitroda Sean P. , Stack Melinda E. , Liu Gene-Fu , Song Sui-Sui , Chen Lucy , Liang Hua , Parekh Akash D. , Huang Xiaona , Roach Paul , Posner Mitchell C. , Weichselbaum Ralph R. , Khodarev Nikolai N. 
Published: February 2018

Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. Approximately 85% of all lung cancers are non–small cell histology [non–small cell lung cancer (NSCLC)]. Modern treatment strategies for NSCLC target driver oncogenes and immune checkpoints. However, less than 15% of patients survive beyond 5 years. Here, we investigated the effects of SAR302503 (SAR), a selective JAK2 inhibitor, on NSCLC cell lines and tumors. We show that SAR is cytotoxic to NSCLC cells, which exhibit resistance to genotoxic therapies, such as ionizing radiation, cisplatin, and etoposide. We demonstrate that constitutive IFN-stimulated gene expression, including an IFN-related DNA damage resistance signature, predicts for sensitivity to SAR. Importantly, tumor cell–intrinsic expression of PD-L1 is IFN-inducible and abrogated by SAR. Taken together, these findings suggest potential dual roles for JAK2 inhibitors, both as a novel monotherapy in NSCLCs resistant to genotoxic therapies, and in tandem with immune checkpoint inhibition. Mol Cancer Ther; 17(4); 732–9. ©2018 AACR.
The True Meaning of the Work of Saturnino Herrán: The False
Critics
Authors: Mérida Carlos 
Published: February 2018

Abstract
The introductory essay places “The True Meaning of the Work of Saturnino Herrán: The False Critics” (1920), a piece of early criticism written by the Guatemalan artist Carlos Mérida during the first year he lived in Mexico City, within the contexts of the cosmopolitan milieu of post-Revolutionary Mexico and the artist's own trajectory. It suggests that the text both demonstrates intellectuals’ interest in questions of form and national art and Mérida's desire to provide a critical framework for his own paintings of indigenous Guatemalan and Mexican women. In “The True Meaning of the Work of Saturnino Herrán: The False Critics,” Mérida lashed out at Mexican critics for praising Herrán as the best and most Mexican painter of the time, arguing, instead that the realism and sentimentalism of Herrán's paintings dishonored national themes by presenting them as picturesque stereotypes. Published in the widely-read magazine El Universal Ilustrado, the text attacks Herrán's paintings and the critics who praise them while also arguing that the predominance of the artist is symptomatic of the predominant problem of the literary nature of Mexican artists’ engagement with autochthonous art and culture.
Does the use of a multi-trait, multi-test approach to measure animal personality yield different behavioural syndrome results?
Authors: Huang Ping , Kimball Rebecca T. , St. Mary Colette M. 
Published: February 2018

AbstractA multi-trait, multi-test approach to investigate the convergence or discrimination between behavioural tests putatively targeting the same or different animal personality traits has been recommended, yet whether and how the approaches affect the identification of behavioural syndrome(s), the suite of correlated personality traits, requires investigation. Here, we used behavioural measures collected from five commonly used behavioural tests targeting three personality traits, evaluated their convergence/discrimination through exploratory factor analysis (EFA), and then explored whether the identification of syndrome changed based on the approach we used to quantify personality traits. Our results indicated that tests presumably targeting the same personality trait actually measured distinct behavioural aspects. Syndrome defined using correlation changed due to how we identified personality traits, but not when using structural equation models (SEMs). Overall, this study emphasizes that it is critical to clarify the approach and terms we use for ‘personality traits’ in the field of animal personality.
Cybersickness: a Multisensory Integration Perspective
Authors: Gallagher Maria , Ferrè Elisa Raffaella 
Published: February 2018

AbstractIn the past decade, there has been a rapid advance in Virtual Reality (VR) technology. Key to the user’s VR experience are multimodal interactions involving all senses. The human brain must integrate real-time vision, hearing, vestibular and proprioceptive inputs to produce the compelling and captivating feeling of immersion in a VR environment. A serious problem with VR is that users may develop symptoms similar to motion sickness, a malady calledcybersickness. At present the underlying cause of cybersickness is not yet fully understood. Cybersickness may be due to a discrepancy between the sensory signals which provide information about the body’s orientation and motion: in many VR applications, optic flow elicits an illusory sensation of motion which tells users that they are moving in a certain direction with certain acceleration. However, since users are not actually moving, their proprioceptive and vestibular organs provide no cues of self-motion. These conflicting signals may lead to sensory discrepancies and eventually cybersickness. Here we review the current literature to develop a conceptual scheme for understanding the neural mechanisms of cybersickness. We discuss an approach to cybersickness based on sensory cue integration, focusing on the dynamic re-weighting of visual and vestibular signals for self-motion.
How Well Does Noah-MP Simulate the Regional Mean and Spatial Variability of Topsoil Water Content in Two Agricultural Landscapes in Southwest Germany?
Authors: Poltoradnev M. , Ingwersen J. , Imukova K. , Högy P. , Wizemann H.-D. , Streck T. 
Published: February 2018

Abstract
The spatial variability of topsoil water content (SWC) is often expressed through the relationship between its spatial mean 〈θ〉 and standard deviation σθ. The present study tests the concept that a reasonably performing land surface model (LSM) should be able to produce σθ–〈θ〉 data pairs that fall into a polygon, spanned by the cloud of observed data and two anchor points: σθ at the permanent wilting point σθ–〈θwp〉 and σθ at saturation σθ–〈θs〉. A state-of-the-art LSM, Noah-MP, was driven by atmospheric forcing data obtained from eddy covariance field measurements in two regions of southwestern Germany, Kraichgau (KR) and Swabian Alb (SA). KR is characterized with deep loess soils, whereas the soils in SA are shallow, clayey, and stony. The simulations series were compared with SWC data from soil moisture networks operating in the two study regions. The results demonstrate that Noah-MP matches temporal 〈θ〉 dynamics fairly well in KR, but performs poorly in SA. The best match is achieved with the van Genuchten–Mualem representation of soil hydraulic functions and site-specific rainfall, soil texture, green vegetation fraction (GVF) and leaf area index (LAI) input data. Nevertheless, most of the simulated σθ–〈θ〉 pairs are located outside the envelope of measurements and below the lower bound, which shows that the model smooths spatial SWC variability. This can be mainly attributed to missing topography and terrain information and inadequate representation of spatial variability of soil texture and hydraulic parameters, as well as the model assumption of a uniform root distribution.
Do High-Frequency Radars Measure the Wave-Induced Stokes Drift?
Authors: Chavanne Cédric 
Published: February 2018

ABSTRACTHigh-frequency (HF) radars remotely measure ocean near-surface currents based on the Doppler shift of electromagnetic waves backscattered by surface gravity waves with half the electromagnetic wavelength, called Bragg waves. Since their phase velocity is affected not only by wave–current interactions with vertically sheared mean Eulerian currents but also by wave–wave interactions with all the other waves present at the sea surface, HF radars should measure a quantity related to the Stokes drift in addition to mean Eulerian currents. However, the literature is inconsistent—both theoretically and experimentally—on the specific expression and even on the existence of the Stokes drift contribution to the HF radar measurements. Three different expressions that have been proposed in the literature are reviewed and discussed in light of the relevant published experimental results: 1) the weighted depth-averaged Stokes drift, 2) the filtered surface Stokes drift, and 3) half of the surface Stokes drift. Effective measurement depths for these three expressions are derived for the Phillips wave spectrum. Recent experimental results tend to discard the second expression but are not inconsistent with the first and third expressions. The latter is physically appealing, since it is a quasi-Eulerian quantity that would be measured by a current meter at a fixed horizontal position but allowed to follow the free surface moving vertically up and down with the passage of the waves. A definitive answer will require further experimental investigations.
The mineralogy and firing behaviour of pottery clays of the Lake Van region, eastern Turkey
Authors: Aras A. , Kiliç S. 
Published: February 2018

AbstractThe present study focused on the mineralogical and chemical characterization and firing behaviour of clays from the Lake Van region and compared them with the same characteristics established for two ancient pot sherds. Four pottery clays collected from Kutki and Kuşluk in the Kesan Valley to the south, from Kavakbaşı to the southwest and from Bardakçı village on the east coast of Lake Van were analysed by X-ray diffraction to identify mineralogical composition (bulk clays and <2 μm fractions after heating at 300–500°C and ethylene glycol solvation). Further analyses were conducted to determine the size distribution, chemical composition and physical properties of test bodies derived from these clays. The in situ weathered schist forming the primary micaceous red clays which are suitable for local pottery production are characterized by large muscovite-sericite-illite and small calcite contents. In contrast, the Bardakçı clays are dominated by large smectite contents and are only used sparingly in mixtures of local pottery production because they undergo firing shrinkage and present drying and firing flaws in the fired bodies. Firing ranges of ~800–900°C were inferred from the mineralogy and colours of the two ancient sherds from Kutki. As a result of mineralogical analysis of fired and unfired test bodies of these pottery clays and pot sherds, two different types of pastes were determined for pottery production in the Lake Van region: metamorphic and volcanic paste, the former characterized by a calcite-poor and mica-sericite-rich matrix and the latter by large smectite and small calcite contents.
Prevalence and predictors of involuntary psychiatric hospital admissions in Ontario, Canada: a population-based linked administrative database study
Authors: Lebenbaum Michael , Chiu Maria , Vigod Simone , Kurdyak Paul 
Published: February 2018

BackgroundInvoluntary admissions to psychiatric hospitals are common; however, research examining the trends in prevalence over time and predictors is limited.AimsTo examine trends in prevalence and risk factors for involuntary admissions in Ontario, Canada.MethodWe conducted an analysis of all mental health bed admissions from 2009 to 2013 and assessed the association between patient sociodemographics, service utilisation, pathway to care and severity characteristics for involuntary admissions using a modified Poisson regression.ResultsWe found a high and increasing prevalence of involuntary admissions (70.7% in 2009, 77.1% in 2013, 74.1% overall). Individuals with police contact in the prior week (risk ratio (RR) = 1.20) and immigrants both experienced greater likelihood of being involuntarily admitted, regardless of control for other characteristics (RR = 1.07) (both P < 0.0001).ConclusionsWe identified numerous modifiable and non-modifiable risk factors for involuntary admissions. The prevalence of involuntary admissions was high, linearly increasing over time.Declaration of interestThe authors have completed the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. This study was conducted using funding entirely from public sources. P.K. has received operational support via an Ontario Ministry of Health and Long-Term Care (MOHLTC) Health Services Research Fund Capacity Award to support this project. The Institute for Clinical Evaluative Sciences (ICES) is funded by the Ontario MOHLTC. The study results and conclusions are those of the authors, and should not be attributed to any of the funding agencies or sponsoring agencies. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. All decisions regarding study design, publication, and data analysis were made independent of the funding agencies.
Achieving better health for people with intellectual disability: the power of policy
Authors: Sheehan Rory , Lunsky Yona , Hassiotis Angela 
Published: February 2018

SummaryPeople with intellectual disability have high mental and physical healthcare needs, which must be addressed on individual, local and national levels. Policy interventions informed by research and stakeholder views and extending beyond a focus on health are needed to reduce inequities in this group.Declaration of interestNone.
Castrate-resistant prostate cancer: lessons learnt from a pilot study in the palliative care research population
Authors: Sullivan Karyn A , Kingi Ngaire , Good Phillip , Vayne-Bossert Petra , Hardy Janet R 
Published: February 2018

Background: Palliative care patients are inherently difficult to recruit to and retain on studies. Even when patients are recruited, it is hard to complete studies with sufficient data. There is a dearth of literature specific to men with castrate resistant prostate cancer (CRPC) and the clinical trials coordinator/research nurse's perspective in improving trial outcomes in palliative care. Objectives To describe the lessons learnt (by the nursing research team) from a prospective cohort study of men with CRPC and the practical implications for future research in this area. Methods: A pilot feasibility cohort study that followed patients with CRPC from referral until death. The participants completed questionnaires while the researcher documented treatments, disease status and symptom burden. The recruitment methods, data quality and results were analysed. Results and discussion: Several lessons have been learnt with regard to facilitating trial recruitment and design. These lessons are: the importance of building relationships with local urology teams, including all men with the diagnosis of CRPC as documented by a medical oncologist or urologist, reducing questionnaire burden, capturing symptom scores in clinic, actively following up patients by phone, and recording all reasons for drop-out or lost to follow-up. These lessons can now be implemented to improve future studies involving this demographic.
Heading east: Spanish Bengali collisions in El próximo oriente/The Next Orient
Authors: Bhowmik Ranjamrittika , Castillo Debra A. 
Published: February 2018

Abstract
In El próximo oriente/The Next Orient (2006), director Fernando Colomo takes on the always controversial issue of immigration from Muslim countries and the European struggle to understand and come to terms with its new multilingual, multicultural reality. In this case, the focus is on the once-again multicultural Spain, which has been dealing in healthy and unhealthy ways with the twin challenges of a high immigration rate and a very low native birth rate. Rather than focusing on the banal plot, however, we think about the importance of the sound track in this film, both spoken and musical (including the Goya-nominated Bengali song, ‘Shokal Fire Ashe’/The Morning Returns, and the crucial information provided in the nonsubtitled exchanges in Bengali by the Bangladeshi immigrant characters.
Music theatre as labyrinth: The extension of liminality in the production The Navidson Records by Till Wyler von Ballmoos and Tassilo Tesche
Authors: Dick Leo 
Published: February 2018

Abstract
For the 2016 edition of the Münchener Biennale – Festival für Neues Musiktheater (‘Munich Biennale – Festival for New Music Theatre’), its new intendants Daniel Ott and Manos Tsangaris organized a series of preparatory workshops intended to promote the creation of new works. This essay explains the influence that this new form of curating process exerted on the gestation of the production The Navidson Records by Till Wyler von Ballmoos and Tassilo Tesche. Our focus is on investigating the working methods employed in the process of conception and rehearsal: the setting of The Navidson Records was from the start intended to avoid creating fixed performance procedures and instead to create an open space of potential. The author analyses the characteristics of that space with the aid of hypotheses derived from ritual theory. A central role here is played by the concept of liminality, which Victor Turner uses to describe the ritual borderline phase between two stable states. This article demonstrates the tendency of current composed theatre to undermine normative patterns of roles and organization by means of strategies of liminalization. The potential and the difficulties inherent in participant observation in a creative work process are also discussed here.
The politics of listening in intercultural artistic practice
Authors: Östersjö Stefan , Thanh Thủy Nguyễn 
Published: February 2018

Abstract
This article offers an analysis of the function of listening in the musical practice of the Vietnamese/Swedish group The Six Tones, based on video documentation recorded between 2006 and 2011. A discussion of the function of openness, drawing on Gadamer, and the distinction between ‘musical’ and ‘musicianly’ listening suggested by Pierre Schaeffer provides the ground for an understanding of mutual learning in cross-cultural artistic practice. Östersjö and Nguyễn identify the same principles in the making of two music theatre works, Idioms (2010–11) and Arrival Cities: Hanoi (2014–15) together with the Swedish playwright and director Jörgen Dahlqvist. The authors, who are both performers in the group, argue that true listening must build on trust that also allows the participating artists to accept the opacity of the other. The ethics implied by the notion of the ‘right to opacity’ also become the ground for a discussion of a politics of listening. Here, the authors claim, following Attali, that the political dimensions of intercultural musical practice can be traced in the hybridity that characterizes the artistic output.
Book Reviews
Authors: Purin Peter , Adamson Charles D. , Rush Adam 
Published: February 2018

Abstract

The Shuberts and their passing shows: The untold tale of Ziegfeld’s rivals, Jonas Westover (2016)
New York: Oxford University Press, 281 pp.,
ISBN: 978-0-19-021923-9, h/bk, £25.99

Her turn on stage: The role of women in musical theatre, Grace Barnes (2015)
Jefferson, NC: McFarland & Company, 210 pp., ISBN: 9780786498611, p/bk, $45.00 (United States)

The Oxford handbook of the British musical, Robert Gordon and Olaf Jubin (Eds) (2017)
New York: Oxford University Press, 776 pp., ISBN: 9780199988747, h/bk, £97
Elizabeth Ferri y Stephen Ferry (2017). La batea. Ícono Editores
Authors: Rueda Fajardo Santiago 
Published: February 2018

El nuevo libro de uno de los fotógrafos que más ha seguido el enrevesado, complejo e interminable conflicto colombiano, Stephen Ferry. Pero el libro es ante todo, un homenaje a los trabajadores del oro en este país. Así como Timothy Prus escogió la vaca y la orquídea como argumento para describir lo que considera una fotografía genérica colombiana, Ferry junto a su hermana Elizabeth, quien realiza con el fotógrafo la investigación y escribe con maestría los textos del libro, han escogido el oro, y en concreto la batea, como herramienta para explicarnos y acercarnos a las luchas de los trabajadores artesanales del metal en tres lugares concretos de Colombia, Segovia, Marmato y Yolombó, con un breve epílogo que suceden en Mompox, donde el artesanato orfebre sobrevive en el tiempo muerto de las riveras del Río Magdalena