bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-institutional collaboration for transfer student success
Authors: Casey Kaela , Kennedy Linda , Pinkley Janet , Worden Laura 
Published: March 2019

Purpose
Each of Ventura County’s four public institutions of higher education list information literacy (IL) as either an institutional outcome or general education outcome for their students. Despite this, communication between the four campuses on this topic was limited. Librarians from these institutions applied to be part of the grant-funded Project ALAS Faculty Fellows Program to find ways to collaborate with each other and with teaching faculty to support the development of IL skills in transfer students.

Design/methodology/approach
Librarians from Ventura County’s four public institutions of higher education, with funding from the Project ALAS Faculty Fellows Program, held a one-day IL summit to bring librarians and teaching faculty together to unify objectives and create a seamless IL transition for transfer students.

Findings
Creating an opportunity for librarians and teaching faculty to discuss the definition and potential applications of IL in courses and assignments led to positive outcomes. Teaching faculty learned about library resources and took steps to begin collaborating with their campus librarian(s). Librarians also learned about different academic expectations in various disciplines, made new connections and made plans for future IL-focused collaborations.

Originality/value
Studies have demonstrated that IL is a key component to student transfer success. However, this is not an element in education that can be achieved by one department alone. The collaborative effort described in this paper can serve as a model for other librarians hoping to foster dialogue and cooperation amongst their regional institutions.
One hundred and counting: Centenarian use of emergency departments in New South Wales
Authors: Mane Gabrielle , Alkhouri Hatem , Dinh Michael , McCarthy Sally 
Published: March 2019

AbstractObjectiveTo study ED utilisation by people aged 100 years and over with a focus on patient demographics, reasons for presentation and patient flow factors.MethodsThis is a retrospective descriptive analysis of linked ED Data Collection Registry for presentations to New South Wales (NSW) EDs over a 5 year period. Patients were included if they presented to an ED and were aged 100 years and over at the time of presentation. Demographics, triage category, presenting problem, ED length of stay, disposition and ED re‐presentation were determined for this age group.ResultsA total of 4033 presentations to 115 NSW EDs during 2010–2014 were analysed. We found that 78% of the patients were females and 76% still living at home. This group were the second most common age group to present to ED, after the 90–99 year age group, with 87% arriving via ambulance. Most presentations were triaged as a category 3 or 4, with the most common presenting problem being because of injury (28.5%) followed by respiratory disease (11.4%) and cardiovascular disease (10.0%). Overall, 64% required hospital admission and the average length of stay for all patients was 5.7 h.ConclusionsCentenarians ED presentations are increasing over time with injuries as the most common reason for presentation. Most patients have prolonged ED length of stay and many require hospital admission. Early streaming of these patients through specialised geriatric assessment units may be more appropriate to reduce the demand on EDs and improve patient care. Models that facilitate rapid access to supported living arrangements and improved advanced care planning may be more realistic for many centenarians and different models of care need to be considered for this age group.
Different incidence of interstitial lung disease according to different kinds of EGFR‐tyrosine kinase inhibitors administered immediately before and/or after anti‐PD‐1 antibodies in lung cancer
Authors: Uchida Takahiro , Kaira Kyoichi , Yamaguchi Ou , Mouri Atsuto , Shiono Ayako , Miura Yu , Hashimoto Kosuke , Nishihara Fuyumi , Murayama Yoshitake , Kobayashi Kunihiko , Kagamu Hiroshi 
Published: March 2019

BackgroundThe aim of our study was to retrospectively assess the incidence of interstitial lung disease (ILD) related to EGFR‐tyrosine kinase inhibitor (TKI) treatment immediately before and/or after the administration of a PD‐1 antibody.MethodsWe analyzed the data of 26 patients who underwent treatment with EGFR‐TKIs immediately before and/or after the administration of an anti‐PD‐1 antibody.ResultsFour out of the 26 patients developed ILD during EGFR‐TKI treatment: three patients during the administration of osimertinib immediately after, and one during afatinib immediately before treatment with an anti‐PD‐1 antibody. Three of 12 patients who underwent EGFR‐TKI therapy immediately after anti‐PD‐1 antibody treatment experienced osimertinib‐induced ILD. ILD was not observed in the five patients administered an anti‐PD‐1 antibody followed by first or second‐generation EGFR‐TKIs.ConclusionILD was observed in the treatment sequence of an anti‐PD‐1 antibody followed by osimertinib, but not with first or second‐generation EGFR‐TKIs.
The prevalence of mental disorders in incarcerated contact sexual offenders
Authors: Eher R. , Rettenberger M. , Turner D. 
Published: March 2019

ObjectiveMental disorders in sexual offenders are relevant in terms of risk assessment and psychotherapeutic and pharmacological treatment.MethodsThe present cross‐sectional study was conducted between 2001 and 2017 and included 1511 sexual offenders who were assessed at the Federal Evaluation Center for Sexual and Violent Offenders in the Austrian Prison System. All sexual offenders were assessed with the Structured Clinical Interview for Axis I (SCID I) and Axis II disorders (SCID II).ResultsN = 1250 (92.9%) sexual offenders were diagnosed with a mental disorder, whereby the great majority received multiple diagnoses. The most frequently found disorders were alcohol misuse (40.0%), paraphilic (43.3%), and personality disorders (53.6%) with a special emphasis on Cluster B personality disorders (47.8%). While sexual offenders against children were more likely to be diagnosed with paraphilic disorders, sexual offenders against adults were more likely to be diagnosed with a personality disorder.ConclusionPrevalence rates of mental disorders in sexual offenders are considerable. Besides specific risk reducing treatment, the psychological and social sequelae of the mental disorder have to be addressed in interventions in order to reach an effective and sustainable risk reduction.
Whatever it takes: Attitude alignment in close relationships following third‐party rejection
Authors: Reid Chelsea A. , Davis Jody L. , Green Jeffrey D. 
Published: March 2019

Individuals seek to affirm their belonging in many ways, but will they change even strongly held attitudes to do so? Attitude alignment is one mechanism by which individuals maintain ongoing relationships. We tested whether individuals would engage in greater attitude alignment (shifting their attitudes to match a romantic partner's attitudes) following rejection. Participants (N = 190) and their dating partners reported their attitudes about 51 social issues and received feedback that a third party (confederate) did or did not reject them. Dating partners then discussed two disagreed‐upon social issues: One issue was peripheral to self and central to partner (PC) and one issue central to self and peripheral to partner (CP). Participants completed a post‐discussion attitude measure. In the absence of rejection, individuals engaged in greater attitude alignment for PC than CP issues; following rejection, they engaged in similarly high levels of attitude alignment for both issue types. Rejected (vs. not rejected) individuals also engaged in greater attitude alignment for CP issues. Rejection led individuals to change centrally held attitudes typically more resistant to change, arguably to enhance their sense of belonging in a valued relationship.
Poly(ADP‐ribose) polymerase‐1 (PARP‐1) regulates developmental morphogenesis and chemotaxis in Dictyostelium discoideum
Authors: Jubin Tina , Kadam Ashlesha , Begum Rasheedunnisa 
Published: March 2019

Background informationPoly(ADP‐ribose) polymerase‐1 (PARP‐1) has been attributed to varied roles in DNA repair, cell cycle, cell death, etc. Our previous reports demonstrate the role of PARP‐1 during Dictyostelium discoideum development by its constitutive downregulation as well as by PARP‐1 ortholog, ADP ribosyl transferase 1 A (ADPRT1A) overexpression. The current study analyses and strengthens the function of ADPRT1A in multicellular morphogenesis of D. discoideum. ADPRT1A was knocked out, and its effect was studied on cAMP signalling, chemotaxis and development of D. discoideum.ResultsWe report that ADPRT1A is essential in multicellular development of D. discoideum, particularly at the aggregation stage. Genetic alterations of ADPRT1A and chemical inhibition of its activity affects the intracellular and extracellular cAMP levels during aggregation along with chemotaxis. Exogenous cAMP pulses could rescue this defect in the ADPRT1A knockout (ADPRT1A KO). Expression analysis of genes involved in cAMP signalling reveals altered transcript levels of four essential genes (PDSA, REGA, ACAA and CARA). Moreover, ADPRT1A KO affects prespore‐ and prestalk‐specific gene expression and prestalk tendency is favoured in the ADPRT1A KO.ConclusionADPRT1A plays a definite role in regulating developmental morphogenesis via cAMP signalling.SignificanceThis study helps in understanding the role of PARP‐1 in multicellular development and differentiation in higher complex organisms.
MicroRNAs as markers to monitor endothelin‐1 signalling and potential treatment in renal disease: Carcinoma − proteinuric damage − toxicity
Authors: Fries Jochen W. U. 
Published: March 2019

AbstractThis review highlights new developments in miRNA as diagnostic and surveillance tools in diseases damaging the renal proximal tubule mediated by endothelin in the field of renal carcinoma, proteinuric kidney disease and tubulotoxicity. A new mechanism in the miRNA regulation of proteins leads to the binding of the miRNA directly to the DNA with premature transcriptional termination and hence the formation of truncated protein isoforms (Mxi2, Vim3). These isoforms are mediated through miRNA15a or miRNA 498, respectively. ET‐1 can activate a cytoplasmic complex consisting of NF‐κB p65, MAPK p38α, and PKCα. Consequently, PKCα does not transmigrate into the nucleus, which leads to the loss of suppression of a primiRNA15a, maturation of this miRNA in the cytoplasm, tubular secretion and detectability in the urine. This mechanism has been shown in renal cell carcinoma and in proteinuric disease as a biomarker for the activation of the signalling pathway. Similarly, ET‐1 induced miRNA 498 transmigrates into the nucleus to form the truncated protein Vim3, which is a biomarker for the benign renal cell tumour, oncocytoma. In tubulotoxicity, ET‐1 induced miRNa133a down‐regulating multiple‐drug‐resistant related protein‐2, relevant for proteinuric and cisplatin/cyclosporine A toxicity. Current advantages and limitations of miRNAs as urinary biomarkers are discussed.
Early low‐dose rituximab for active thyroid eye disease: An effective and well‐tolerated treatment
Authors: Insull Elizabeth A. , Sipkova Zuzana , David Joel , Turner Helen E. , Norris Jonathan H. 
Published: March 2019

SummaryBackgroundThyroid eye disease (TED) is an autoimmune inflammatory disease that can be disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long‐term sequelae. Current management involves inflammation suppression using glucocorticoids. The aim of this study was to evaluate the efficacy of early disease intervention with targeted immunomodulatory therapy to alter disease course. This paper reports the efficacy of low‐dose rituximab in reducing clinical activity in TED in a small population.MethodsA retrospective audit of consecutive patients with active TED managed primarily with a 100 mg rituximab infusion. Further glucocorticoid or steroid‐sparing agents were prescribed if clinically indicated. Clinical activity score, VISA overall severity score and Oxford Quality of Life score were recorded at each visit as well as TSH receptor antibody levels (TRAb), B cell subsets and adverse reactions.ResultsTwelve patients had mean follow‐up of 6.3 months. Clinical activity scores significantly decreased (mean score 5.08 to 1.58; P < 0.001), VISA overall severity scores reduced by 50% from 12 to 6, P < 0.001 and the mean cumulative dose of IV methylprednisolone was 2.3 g. 100 mg rituximab induced significant CD19+ B cell depletion (n = 8, P < 0.001). There was no significant reduction in serum TRAb (n = 8, P = 0.06). A transient infusion‐related rash was the only adverse effect, n = 4. QoL scores did not differ markedly before and after treatment.ConclusionLow‐dose rituximab is an efficacious, well‐tolerated and safe treatment for active TED; reducing disease activity and allowing reduced administration of systemic steroid.
Interobserver agreement on interpretation of conventional dacryocystography and dacryoscintigraphy findings: A retrospective single‐centre study
Authors: Sia Paul I. , Curragh David , Howell Stuart , Selva Dinesh 
Published: March 2019

AbstractImportanceThis study assesses the interobserver agreement on dacryocystography (DCG) and dacryoscintigraphy (DSG) findings.BackgroundThere are no standard grading criteria to guide the interpretation of conventional DCG and DSG findings and therefore there may be a degree of subjectivity. This study evaluates the level of interobserver agreement in the interpretation of DCG and DSG findings.DesignA retrospective observational study at the Royal Adelaide Hospital.ParticipantsA total of 165 patients who presented with epiphora with 276 DCGs and 290 DSGs performed were included in this study.MethodsDCG and DSG images were obtained, anonymized, randomized and interpreted by three independent oculoplastic surgeons. Standard grading criteria were set for both DCG and DSG images. Data from all observers were analysed for interobserver agreement using Kappa (κ) statistics, generated using a variation of Cohen's kappa for multiple observers.Main Outcome MeasuresLevel of interobserver agreement (κ values) in the grading of DCG and DSG findings.ResultsThere was an overall moderate interobserver agreement for DCG findings (κ = 0.55), with the highest agreement on interpreting canalicular obstruction (κ = 0.80), followed by proximal nasolacrimal duct obstruction (κ = 0.67) and normal patency (κ = 0.63). There was an overall fair interobserver agreement for DSG findings (κ = 0.36), with the best being moderate agreement (κ = 0.42‐0.50) for interpreting pre‐sac delay and post‐sac proximal delay.Conclusions and RelevanceDCG offers good reliability in interpreting patent and obstructed systems. On the other hand, DSG has poor agreement and highlights some of the limitations in the ability to guide epiphora management.
Exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway
Authors: Huang Jun , Wang Xue , Zhu Yi , Li Zhe , Zhu Yu‐Ting , Wu Jun‐Chao , Qin Zheng‐Hong , Xiang Min , Lin Fang 
Published: March 2019

SummaryAimTo study the effects of exercise on lysosomal functions.MethodsMouse exercise model was established and wheel running was scheduled as 18 rpm (14:00‐17:00), 5 d/wk, for 8 weeks. Mice were injected EX527 to inhibit SIRT1 activity. The protein level was assayed with Western blot and immunofluorescence histochemistry. The transmission electron microscopic examination was used to show the structure of lysosome and mitochondria.ResultsExercise promoted the nuclear translocation of TFEB in the cortex which upregulated the transcription of genes associated with autophagy and lysosome. Exercise directly activated autophagy/lysosome system via up‐regulating of AMPK‐SIRT1 signaling. The SIRT1 inhibitor EX527 decreased TFEB regulated gene transcription but had little effect on the nuclear translocation of TFEB. In addition, long‐term exercise showed more significant effects on activation of lysosomes biogenesis compared with the short‐term exercise and trehalose, a classical autophagy activator in the mTOR‐independent pathway.ConclusionRunning exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway.
Clinical features and management of superficial fibromatoses
Authors: Kelenjian Shinorik , Mattjie Rebeca Assuncao , Franz Regina , Biedermann Tilo , Brockow Knut 
Published: March 2019

SummaryFibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well‐differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses.Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. They present clinically with subcutaneous nodules or cords that lead to local infiltration and limited mobility of the affected areas.Treatment options vary from watchful waiting, non‐invasive methods such as radiotherapy and intralesional corticosteroid/collagenase injections to radical surgical procedures. Early intervention may disrupt disease progression and may even restore functional ability. These disorders should therefore be recognized and treated early in the course of the disease.
Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug‐resistant focal epilepsy
Authors: Mula Marco , Zaccara Gaetano , Galimberti Carlo Andrea , Ferrò Bruno , Canevini Maria Paola , Mascia Addolorata , Mecarelli Oriano , Michelucci Roberto , Pisani Laura Rosa , Specchio Luigi Maria , Striano Salvatore , Perucca Emilio 
Published: March 2019

SummaryObjectiveAlthough many studies have attempted to describe treatment outcomes in patients with drug‐resistant epilepsy, results are often limited by the adoption of nonhomogeneous criteria and different definitions of seizure freedom. We sought to evaluate treatment outcomes with a newly administered antiepileptic drug (AED) in a large population of adults with drug‐resistant focal epilepsy according to the International League Against Epilepsy (ILAE) outcome criteria.MethodsThis is a multicenter, observational, prospective study of 1053 patients with focal epilepsy diagnosed as drug‐resistant by the investigators. Patients were assessed at baseline and 6, 12, and 18 months, for up to a maximum of 34 months after introducing another AED into their treatment regimen. Drug resistance status and treatment outcomes were rated according to ILAE criteria by the investigators and by at least two independent members of an external expert panel (EP).ResultsA seizure‐free outcome after a newly administered AED according to ILAE criteria ranged from 11.8% after two failed drugs to 2.6% for more than six failures. Significantly fewer patients were rated by the EP as having a “treatment failure” as compared to the judgment of the investigator (46.7% vs 62.9%, P < 0.001), because many more patients were rated as “undetermined outcome” (45.6% vs 27.7%, P < 0.001); 19.3% of the recruited patients were not considered drug‐resistant by the EP.SignificanceThis study validates the use of ILAE treatment outcome criteria in a real‐life setting, providing validated estimates of seizure freedom in patients with drug‐resistant focal epilepsy in relation to the number of previously failed AEDs. Fewer than one in 10 patients achieved seizure freedom on a newly introduced AED over the study period. Pseudo drug resistance could be identified in one of five cases.
A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy
Authors: Casillas‐Espinosa Pablo M. , Sargsyan Armen , Melkonian Dmitri , O'Brien Terence J. 
Published: March 2019

SummaryObjectiveProlonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent models has become an important tool in preclinical drug development of new therapies, in particular those for antiepileptogenesis, disease modification, and treating drug‐resistant epilepsy. We have developed an easy‐to‐use, reliable, computational tool for automated detection of electrographic seizures from prolonged EEG recordings in rodent models of epilepsy.MethodsWe applied a novel method based on advanced time‐frequency analysis that detects EEG episodes with excessive activity in certain frequency bands. The method uses an innovative technique of short‐term spectral analysis, the Similar Basis Function algorithm. The method was applied for offline seizure detection from long‐term EEG recordings from four spontaneously seizing, chronic epilepsy rat models: the fluid percussion injury (n = 5 rats, n = 49 seizures) and post–status epilepticus models (n = 119 rats, n = 993 seizures) of acquired epilepsy, and two genetic models of absence epilepsy, Genetic Absence Epilepsy Rats from Strasbourg and Wistar Albino Glaxo from Rijswijk (n = 41 and 14 rats, n = 8733 and 825 seizures, respectively).ResultsOur comparative analysis revealed that the EEG amplitude spectra of these four rat models are remarkably similar during epileptiform activity and have a single expressed peak within the 17‐ to 25‐Hz frequency range. Focusing on this band, our computer program detected all seizures in the 179 rats. A quick semiautomated user inspection of the EEGs for the period of each identified event allowed quick rejection of artifact events. The overall processing time for 12‐day‐long recordings varied from a few minutes (5‐10) to 30 minutes, depending on the number of artifact events, which was strongly correlated with the signal quality of the raw EEG data.SignificanceOur automated seizure detection tool provides high sensitivity, with acceptable specificity, for long‐ and short‐term EEG recordings from both acquired and genetic chronic epilepsy rat models. This tool has the potential to improve the efficiency and rigor of preclinical research and therapy development using these models.