bluuebunny/crossref_metadata_2025_split huggingface dataset:
One Size Does Not Fit All: Prediction of Nerve Length in Implant-based Nipple–Areola Complex Neurotization
Authors: Zhang Casey , Moroni Elizabeth A. , Moreira Andrea A. 
Published: November 2024

Abstract
Background Breast reconstruction with sensory restoration is gaining recognition as an important goal. Successful reinnervation has been shown in autologous reconstruction but not widely studied in implant-based reconstruction (IBR). This article describes our technique for nipple–areola complex (NAC) neurotization to predict maximal nerve length. We also propose a novel equation that can be utilized preoperatively to estimate the total nerve length required for NAC neurotization.
Methods This is a retrospective study of patients who underwent nerve reconstruction with IBR between April 2021 and May 2022. An equation based on the arc length of a circle was utilized to predict the total nerve length required. Postoperative assessment of sensation was performed at 3, 6, and 12 months using Semmes–Weinstein monofilament testing in all four breast quadrants and the NAC. Patients completed the Breast-Q Sensation Module preoperatively and at 3, 6, and 12 months.
Results NAC neurotization was performed in 58 patients undergoing IBR. The average length of intercostal nerve (ICN) harvested was 5.3 cm for staged reconstructions and 5.6 cm for direct-to-implant reconstruction. The average total nerve length (allograft + mobilized ICN) was 12.3 cm. On average, 6.9 cm of nerve allograft was used. The mean difference between total nerve length and predicted nerve length was 0.47 cm (range −3.5 to 4.6 cm). There was a significant improvement in sensory monofilament values measured in all four breast quadrants and the NAC between 3 to 6 and 6 to 12 months postoperatively.
Conclusion A thorough understanding of sensory anatomy and precise surgical techniques are essential to perform NAC neurotization successfully. Our early results suggest the positive impact of breast sensation on patient quality of life.
Social Determinants of Health Associated with Intimate Partner Violence in an Urban Obstetric Population
Authors: Kuhrau Christina R. , Kelly Elizabeth , DeFranco Emily A. 
Published: November 2024

Objective Intimate partner violence (IPV) is pervasive and can lead to severe health consequences. In the United States, 25% of women have experienced sexual violence, physical violence, and/or stalking by an intimate partner. However, less is known about the frequency and risk factors for IPV in the obstetric population.
Study Design Nested case–control study from a prospective cohort study of 606 parturients at a single academic medical center from 2011 to 2022. Structured questionnaires were administered to randomly chosen, consented patients during their postpartum hospital stay to gather information on social determinants of health (SDoH) and birth outcomes. The case group included participants who reported forced sex causing pregnancy, verbal abuse before or during pregnancy, or physical abuse during pregnancy. The control group reported none of these. Odds ratios were used to quantify the relationship between IPV and maternal sociodemographic characteristics, pregnancy factors, and levels of perceived support and discrimination.
Results Of 606 study participants, 568 (94%) provided data on IPV. Of those, 20.4% reported IPV (case) and 80.6% reported no IPV (control). In total, 74.6% of the study population was enrolled prepandemic. Unmarried status, low income, food insecurity, housing insecurity, substance use during pregnancy, higher gravidity, unintended pregnancy, low social support, and racial and gender discrimination were all significantly associated with IPV; maternal race and pregnancy during the COVID-19 pandemic were not.
Conclusion IPV is common, reported by one in five parturients in our population. Although maternal race was not associated with IPV in this perinatal cohort, experiencing racism was. Initiatives aimed to address SDoH such as substance use, family planning, and access to food and housing remain key opportunities to support pregnant patients experiencing IPV. The connection between perceived discrimination and IPV found here highlights the importance of addressing the influence of racism and gender-based discrimination on adverse birth outcomes in the United States.
Key Points
Neutrophil Extracellular Traps, Platelets and Endothelial Cells Cooperatively Contribute to Hypercoagulability in Non-Small Cell Lung Cancer
Authors: Tong Dongxia , Gao Yuan , Sun Weihua , Yang Jie , Liu Yang , Li Jihe , Zhang Yan 
Published: November 2024

Background Thromboembolism is the second leading cause of death among patients with non-small cell lung cancer (NSCLC), but the precise mechanisms of thrombogenesis in NSCLC remain largely unknown. Our objectives were to evaluate the definitive role of neutrophil extracellular traps (NETs) in the hypercoagulability in NSCLC and to explore its interactions with platelets and endothelial cells (ECs).
Methods The levels of NET markers in samples from 100 NSCLC patients and 30 healthy controls were measured by ELISA. NET formation was detected using immunofluorescence. Procoagulant activity was assessed based on purified coagulation complex, thrombin, clotting time, and fibrin formation assays.
Results The plasma levels of NETs were increased in a stage-dependent manner in NSCLC patients and were markedly higher than those in controls. Neutrophils from NSCLC patients were more prone to form NETs, resulting in shortened coagulation time, significantly increased thrombin–antithrombin complexes and fibrin compared to controls. Moreover, NETs generation was mediated by High Mobility Group Box 1 from activated platelets in NSCLC patients. Conversely, NETs from NSCLC patients also induce phosphatidylserine exposure on platelets, leading to markedly enhanced procoagulant activity (PCA). Furthermore, NETs can damage endothelial cells and convert them to a procoagulant phenotype. The administration of NETs inhibitors (DNase I/activated protein C) could markedly diminish the PCA of NETs, activated platelets, and ECs.
Conclusion Our results suggest that NETs contribute to hypercoagulability and may represent a potential therapeutic target to prevent cancer-associated thrombosis in NSCLC patients.
Consecutive Sonogashira–Suzuki–Michael Cyclization: Three-Component Synthesis of Phenanthridines and Benzo[c]chromenes
Authors: Müller Thomas J. J. , Schmitz G. Hendrik , Karl Leonard , Ganter Christian 
Published: November 2024

AbstractThe equistoichiometric three-component reaction of an acid chloride, an alkyne, and an ortho-amino- or ortho-hydroxyphenylboronic ester proceeds smoothly to give phenanthridines or benzo[c]chromenes, respectively, with good to quantitative yields in the sense of a Sonogashira–Suzuki–Michael cyclization sequence. In the coupling of ortho-amidophenylboronates, interestingly, after ring closure a subsequent an acyl migration occurs to give 6-(2-(acyloxy)vinyl)phenanthridines.
Scandium(III) Triflate Catalyzed Reductive Etherification of Carbonyl Compounds with Alcohols Using 1,1,3,3-Tetramethyldisiloxane as the Reducing Agent
Authors: Nobuta Tomoya , Mineno Tomoko , Yamagiwa Noriyuki 
Published: November 2024

AbstractIn this study, we present a straightforward protocol for the reductive etherification of carbonyl compounds with alcohols using a catalytic amount of scandium(III) triflate [Sc(OTf)3] and 1,1,3,3-tetramethyldisiloxane to produce nonsymmetrical ethers. The reaction proceeds under mild room-temperature conditions and accommodates a broad range of substrates, including α,β-unsaturated aldehydes, yielding the desired products in good to excellent yields. Notably, the catalyst loading of Sc(OTf)3 could be reduced to 0.1 mol%.
Direct One-Pot Synthesis of Tetrazole Derivatives from Aldehydes under Metal-Free Conditions
Authors: Ahmed Naseem , Singh Rajeev 
Published: November 2024

AbstractA simple and efficient one-pot protocol has been developed for the synthesis of 1H-tetrazole and 1-methyltetrazole derivatives from aldehydes under mild and metal-free conditions using ammonium azide or methyl azide, respectively. A number of tetrazole derivatives were obtained in moderate to high yields (75–92%) in green solvents at a moderate temperature. These reactions presumably proceed through the formation of a nitrile in situ. The mild conditions and the easy workup and purification make this method highly valuable.
Synthesis of Chiral Cyclopentadienyl Rhodium Complexes and Their Application in Enantioselective C–H Functionalization Reactions
Authors: You Shu-Li , Gou Bo-Bo , Shen Wen-Jie , Gu Qing 
Published: November 2024

AbstractIn recent years, rhodium catalysis has evolved as a powerful tool for chemo- and stereocontrolled syntheses of chiral molecules through C–H functionalization. In particular, chiral cyclopentadienyl rhodium (CpRh) complex-catalyzed asymmetric C–H functionalization reactions have gained ever-increasing attention in organic synthesis. However, the design and synthesis of novel chiral Cp ligands remain challenging due to the difficulty of imparting chiral elements into the Cp moiety. In this account, we introduce our research progress in the syntheses of chiral cyclopentadienyl ligands and their applications in rhodium-catalyzed asymmetric C–H functionalization reactions.1	Introduction2	SCpRh-Catalyzed Enantioselective C–H Functionalization Reactions3	CpmRh-Catalyzed Enantioselective C–H Functionalization Reactions4	BOCpRh-Catalyzed Enantioselective C–H Functionalization Reactions5	BCSCpRh-Catalyzed Enantioselective C–H Functionalization Reactions6	Conclusion
Ureterolithiasis with Hydroureteronephrosis Treated by Individualized Homoeopathy: A Case Report
Authors: Parui Patranu , Dey Neelavna , Sarkar Abdul Wahab , Bhattacharjee Baidurjya 
Published: November 2024

AbstractUreteric stones are a common surgical condition in the modern world. Ureteric stones are associated with severe pain, hematuria, hydronephrosis, urinary infections, nausea, and vomiting. A plethora of causes are responsible for the formation of such stones, with modern lifestyle and poor eating habits as some leading risk factors. Conventional treatment mostly relies on surgical means, whereas homoeopathy can successfully expel the stone without any invasive methods and can be a safer and acceptable alternative to surgery. In this case a 25-year-old male presented with a complaint of pain in the right flank and lower abdomen associated with a burning sensation after urination. Pain aggravated from the afternoon up to midnight. He was taking analgesic medicines without any significant relief. After failure to relieve pain from conventional therapies, the patient resorted to homoeopathic treatment. After a thorough case-taking, analysis, and repertorization, Lycopodium clavatum was prescribed. The patient was better within a few days and reported that the stone was expelled through the urethra which was confirmed by ultrasound examination. The pain visual analog scale, measuring 8 at baseline, was improved to “no pain” at the end of the treatment. The Modified Naranjo Criteria for Homoeopathy with a +8 score demonstrated positive causality of homoeopathic treatment. This case study reveals a certain role of homoeopathic treatment in ureterolithiasis and demonstrates the potential of homoeopathy in surgical conditions.
A Survey on Hearing Loss, Dizziness, and Balance Problems as Fall Risk Factors: Responses of Older Adults Seen by Audiologists
Authors: Criter Robin E. 
Published: November 2024

Abstract
Background Falls are a significant health care concern for older adults in the United States. Audiologists are health care providers who are experts in hearing and vestibular dysfunctions, two areas known to be risk factors for falls. It is not known whether audiology patients consider audiology services to be related to falls or whether they consider audiologists to be a viable resource related to fall-related health care.
Purpose The purpose of this study was to investigate whether audiology patients consider (1) hearing, dizziness, and balance difficulties as risk factors for falls, and (2) audiologists as health care providers who can address fall risk, assessment, and prevention.
Research Design This was a cross-sectional survey study.
Study Sample In total, 78 community-dwelling audiology patients aged 60 years or older were included in the study.
Intervention Not applicable
Data Collection and Analysis To reach a broad group of participants, online surveys (Qualtrics) and paper-and-pencil surveys (at the university clinic) were used. The analysis included descriptive statistics and independent-samples t-tests.
Results Nearly half of participants (48.7%) fell within the preceding year, and almost three-quarters (72.4%) felt falls were an important health care concern for them. Fewer than half (43.4%) considered hearing loss to be a fall risk factor, compared to dizziness (92.2%) and balance problems (97.3%). Slightly over half (53.3%) agreed that audiologists can address falls, fall risk, and prevention. However, only 39.5% would discuss falls with their audiologist, compared to 57.9% for dizziness and balance concerns and 90.5% for hearing concerns. No significant differences were found between participants who reported a recent fall and those who did not.
Conclusions Targeted patient education regarding the audiology scope of practice as it pertains to fall risk and prevention may be warranted, particularly if hearing loss is a modifiable fall risk factor which can be addressed through seeking audiologic services.
Assessing the Current Landscape and Future Directions of Digital Denture Technology
Authors: Saini Ravinder S. , Zafar Muhammad Sohail , Adanir Necdet , Alarcón-Sánchez Mario Alberto , Heboyan Artak 
Published: November 2024

AbstractDigital dentures are removable dental prostheses fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM) technology. This study aimed to explore the trends in digital dentures. A comprehensive four-phase search and selection strategy was framed.Dimensions and Lens.org databases were used. Boolean operators were used to combine keywords.The most significant growth occurred by 2021, with 71 publications and 984 citations. Egypt had the highest publication rankings, with 46 total publications (TP) and 45 total citations (TC). The University of Geneva played a significant role in contributing to 16 TP and 491 TC. Egyptian Dental Journal ranked at the top. The group with four authors had an even higher number of authorships, with a total of 60. The top four keywords were CAD/CAM, 3D printing, CAD-CAM, complete denture, and digital dentistry. The Glossary of Prosthodontic Terms, Ninth Edition, was referenced 614 times and had the highest average number of citations (75.2). The top three writers had strong relationships with the three sources and preferred to publish using four keywords. The 11-author group, cluster 6, had the highest level of network cooperation.In conclusion, research on digital dentures has grown in terms of number of articles and citations.
Second Opinion in Medical Oncology in the Age of Artificial Intelligence and Telemedicine
Authors: Giglio Auro del , Serrano Sergio Vicente , Costa Mateus Uerlei Pereira da 
Published: November 2024

AbstractThe present review explores the role and impact of second opinions in medical oncology, particularly considering the recent advancements in artificial intelligence (AI) and telemedicine. A comprehensive literature search was conducted, and data from various studies were analyzed, highlighting why patients seek a second opinion, the rates of disagreement between the first and second opinions, and the potential barriers to obtaining a second opinion. The results showed that seeking a second opinion is common, with patients often seeking reassurance and a better understanding of their diagnosis and treatment options. However, there is limited evidence on the impact of second opinions on patient outcomes and the cost of care. Additionally, the introduction of Multidisciplinary Molecular Tumor Boards, AI, and telemedicine may improve decision-making and treatment strategies in the context of second opinions. Further research is needed to fully understand the role and implications of second opinions in medical oncology and how these recent technologies impact the second opinion process.
Knowledge and Practice of Dental Health among Pregnant Women in a Selected Hospital Mangaluru
Authors: Jojo Ann Maria , D'Souza Pramila , Abraham Anju , Korah Ann Mary , Anvita Anvita 
Published: November 2024

Abstract
Introduction Oral health is a significant part of prenatal care: health of the mouth, teeth, and gums. Pregnant mothers are more prone to cavities due to hormone surges and a change in eating habits. Although dental health is a crucial component of general health, midwives and obstetricians tend to ignore these aspects unless women complain about dental pain. This study aims to assess pregnant women's dental health knowledge and practices.
Materials and Methods A descriptive correlational research design was adopted for the study. A total of 256 women were selected by using a purposive sampling technique from the antenatal wards and outpatient departments of a tertiary hospital in Mangaluru. The data were collected using the demographic proforma, structured knowledge questionnaire, and self-reported practice checklist on dental health.
Result The mean age of the women was 27.93 ± 4.72 years. Out of the total number of women selected for the study, 56.6% were housewives, 61.7% were women from below the poverty line, and 57.8% were from rural areas. Regarding knowledge and practice, 66.4% of pregnant women had poor knowledge of dental care and 97.7% of them had an unfavorable practice of dental care during pregnancy. There was a moderate correlation between knowledge and practice of dental health during pregnancy (r = 0.038; p = 0.03).
Conclusion The study findings show that dental care or oral health care is neglected during pregnancy.
Knowledge About Genetics in Congenital Hearing Loss: A Survey Among Audiologists
Authors: Kaur Navleen , Deshpande Shweta 
Published: November 2024

Abstract
Introduction According to the World Health Organization, there are more than 63 million people in India who have disabling hearing loss. Hearing loss at birth can be caused due to genetic factors. Referral for genetic testing and counseling can be directly influenced by the knowledge among the audiologists. Specific guidelines and recommendations have been provided by experts in the field for competency in genetics among professionals to ensure early and appropriate management in young children with hearing loss. In India, there is limited research done on assessing audiologists' knowledge concerning the importance of genetic testing and counseling. Thus, the present study aimed to explore the knowledge about the role of genetics in congenital hearing loss among audiologists.
Method The study was conducted in two phases. Phase I included the development and validation of the questionnaire. Phase II included the administration of the questionnaire to the professionals from the field of audiology and speech-language pathology through Google Forms.
Results The study findings revealed that the knowledge level about general genetics was adequate; however, aspects related to genetic testing and syndromic and nonsyndromic congenital hearing loss were moderate. There was a statistically significant difference observed in the scores obtained by professionals who had completed Master of Science in Audiology as compared to those who had completed Bachelors in Audiology and Speech Language Pathology and Masters in Audiology and Speech Language Pathology.
Conclusion The study has highlighted the current knowledge of audiologists with respect to domains of genetic testing and syndromic and nonsyndromic congenital hearing loss. There is a need to educate audiologists working in the area of early identification and intervention about the genetic basis of hearing loss.
Level of Competency among Palestinian Nurses Regarding Electrocardiogram Interpretation and Arrhythmias Management: A Cross-Sectional Study
Authors: Qaddumi Jamal , Omar Sewar , Alsadi Ahmad , Kanan Huthaifah , Mahmoud Manar , Dwikat Mohammed 
Published: November 2024

Abstract
Background Electrocardiographic (ECG) interpretation skills are key in providing fast attention to patients with cardiovascular diseases, enabling prevention or early detection of life-threatening situations. The main aim of the study is to determine the current competency level in ECG interpretation and arrhythmias management of nurses in critical and noncritical departments.
Method A cross-sectional design using a convenience sample of 251 nurses working in critical and noncritical departments of Northern West Bank hospitals was used. A valid and reliable structured questionnaire was used to collect data that were designed to measure the competency level in ECG interpretation and arrhythmias management.
Result About half of the participants were females (50.2%), with a mean age of 29.2 ± 5.68 years, and 50.2% of them reported they received ECG courses. Unfortunately, low competency levels in ECG interpretation and arrhythmias management of nurses in critical and noncritical departments were found as only 17.1% of the participants were competent (≥7.5 out of 10). Nurses working in critical care units, males, and those with higher education levels scored significantly higher than those working in noncritical units, females, and those with a bachelor's degree or diploma. Unfortunately, nurses had low competency levels not only in ECG rhythm interpretation but also in the management of arrhythmia cases.
Conclusion The level of competency in ECG interpretation and arrhythmias management among Palestinian nurses is low as only 17.1% of participants were competent in ECG interpretation and arrhythmia management. Thus, this can be considered a serious and alarming situation especially when dealing with a malignant lethal arrhythmia. Therefore, improving nurses' knowledge of ECG interpretation and management of cardiac arrhythmias is essential and warranted.