bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geoarchaeology of Holocene oasis formation, hydro-agricultural management and climate change in Masafi, southeast Arabia (UAE)
Authors: Purdue Louise , Charbonnier Julien , Régagnon Emmanuelle , Calastrenc Carine , Sagory Thomas , Virmoux Clément , Crépy Mael , Costa Sophie , Benoist Anne 
Published: March 2019

AbstractOases are subject to decreasing resources and changing human activities. Fully aware of their rich heritage, the United Arab Emirates (UAE) have undertaken work to preserve and revitalize these oases. However, there is a clear lack of understanding of the dynamic links between climate change, hydraulic and agricultural management, and socioeconomic activities. To clarify these links, our team conducted a systematic geoarchaeological, geophysical, spatial, and chronological study of the Masafi oasis, UAE. Results indicate the existence of a natural humid area as early as the late Pleistocene (~18 cal ka BP). These conditions persist during the early-mid Holocene with drainage activation and soil development (~12–6.3 ka). During the late Holocene, after the emergence of the “artificial” oasis around ~3250 cal yr BP, cycles of intense management suggesting water availability (~3250–2380 cal yr BP; 550 cal yr BP) alternate with episodes of fluvial detritism (~2380–1870 cal yr BP; >550 cal yr BP) and scattered evidence of farming activities with complex hydroclimatic signatures (~2300–550 cal yr BP). These results, together with regional environmental data, indicate that water and soil resources were available and exploited strategically throughout the Holocene despite adverse climatic conditions, and the oasis of Masafi could have acted as a desertrefugium.
Relationship of the posterior septal angle to the anterior nasal spine in the Caucasian nasal septum
Authors: Goh S , Karamchandani D , Anari S 
Published: March 2019

AbstractObjectiveThis study aimed to determine the distance between the most anterior part of the anterior nasal spine and the posterior septal angle.MethodsSinus computed tomography images from February to April 2016 were retrospectively analysed. Scans from adult Caucasians were included. Those with evidence of previous surgery, large slices or poor quality were excluded. The distance between the posterior septal angle and the most anterior part of the anterior nasal spine was measured digitally by two independent raters.ResultsOf 122 scans, 100 met the inclusion criteria (49 males and 51 females; mean age of 52.5 years). The mean distance measured was 5.13 mm (standard deviation = 1.24 mm, range = 1.85–8.00 mm). Measurements between male and female patients were not significantly different (t=0.450, p=0.654, 95 per cent confidence interval = -0.382 to 0.606).ConclusionThere is variability in the distance between the anterior nasal spine and the posterior septal angle. Surgeons should observe this relationship intra-operatively to avoid instability and unintended aesthetic changes.
Measles and rubella seroprevalence in a population of young adult blood donors, France 2013
Authors: Antona D. , Morel P. , Jacquot C. , Fonteneau L. , Dina J. , Vauloup-Fellous C. , Gimeno L. , Degeorges A. , Gallian P. , Lévy-Bruhl D. 
Published: March 2019

AbstractAs part of the evaluation of the French plan for the elimination of measles and rubella, we conducted a seroprevalence survey in 2013, aimed at updating seroprevalence data for people 18–32 years old. A secondary objective was to estimate measles incidence in this population during the 2009–2011 outbreak, and thus estimate the exhaustiveness of measles mandatory reporting. We used a cross-sectional survey design, targeting blood donors 18–32 years old, living in France since 2009, who came to give blood in a blood collecting site. We included 4647 people in metropolitan France, 806 people in Réunion Island and 496 in the French Caribbean. A further 3942 individuals were interviewed in the south-east region of metropolitan France to estimate the exhaustiveness of measles mandatory reporting. One of the main findings of this survey is that the proportion of people 18–32 years old susceptible to both measles and rubella infections remained high in France in 2013, 9.2% and 5.4%, respectively, in metropolitan France, even after the promotion campaigns about vaccination catch-up during and following the major measles epidemic in 2009–2011. Applying our results to French census data would suggest that around 1 million people aged 18–32 years old are currently susceptible to measles in France, despite this age group being one of the vaccination targets of the national measles elimination plan. Another important finding is that only an estimated 45% of the true number of cases in this age group was actually notified, despite notification being mandatory.
Louse-borne relapsing fever (Borrelia recurrentisinfection)
Authors: Warrell David A. 
Published: March 2019

AbstractLouse-borne relapsing fever (LBRF) is an epidemic disease with a fascinating history from Hippocrates’ times, through the 6th century ‘Yellow Plague’, to epidemics in Ireland, Scotland and England in the 19th century and two large Afro-Middle Eastern pandemics in the 20th century. An endemic focus persists in Ethiopia and adjacent territories in the Horn of Africa. Since 2015, awareness of LBRF in Europe, as a re-emerging disease, has been increased dramatically by the discovery of this infection in dozens of refugees arriving from Africa.The causative spirochaete,Borrelia recurrentis, has a genome so similar toB. duttoniiandB. crocidurae(causes of East and West African tick-borne relapsing fever), that they are now regarded as merely ecotypes of a single genomospecies. Transmission is confined to the human body lousePediculus humanus corporis, and, perhaps, the head louseP. humanus capitis, although the latter has not been proved. Infection is by inoculation of louse coelomic fluid or faeces by scratching. Nosocomial infections are possible from contamination by infected blood. Between blood meals, body lice live in clothing until the host's body temperature rises or falls, when they seek a new abode.The most distinctive feature of LBRF, the relapse phenomenon, is attributable to antigenic variation of borrelial outer-membrane lipoprotein. High fever, rigors, headache, pain and prostration start abruptly, 2–18 days after infection. Petechial rash, epistaxis, jaundice, hepatosplenomegaly and liver dysfunction are common. Severe features include hyperpyrexia, shock, myocarditis causing acute pulmonary oedema, acute respiratory distress syndrome, cerebral or gastrointestinal bleeding, ruptured spleen, hepatic failure, Jarisch–Herxheimer reactions (J-HR) and opportunistic typhoid or other complicating bacterial infections. Pregnant women are at high risk of aborting and perinatal mortality is high.Rapid diagnosis is by microscopy of blood films, but polymerase chain reaction is used increasingly for species diagnosis. Severe falciparum malaria and leptospirosis are urgent differential diagnoses in residents and travellers from appropriate geographical regions.High untreated case-fatality, exceeding 40% in some historic epidemics, can be reduced to less than 5% by antibiotic treatment, but elimination of spirochaetaemia is often accompanied by a severe J-HR.Epidemics are controlled by sterilising clothing to eliminate lice, using pediculicides and by improving personal hygiene.
Oral fluid testing facilitates understanding of hepatitis A virus household transmission
Authors: Haywood Becky , Tedder Richard S. , Beebeejaun Kazim , Balogun Koye , Mandal Sema , Andrews Nick , Ngui Siew Lin 
Published: March 2019

AbstractThe public health response to sporadic hepatitis A virus (HAV) infection, hepatitis A, can be complex especially when the index case is a child and no obvious source is identified. Identifying an infection source may avoid mass immunisation within schools when transmission is found to have occurred within the household. Screening of asymptomatic contacts via venepuncture can be challenging and unacceptable, as a result non-invasive methods may facilitate public health intervention. Enzyme-linked immunoassays were developed to detect HAV immunoglobulin M (IgM) and immunoglobulin G (IgG) in oral fluid (ORF). A validation panel of ORF samples from 30 confirmed acute HAV infections were all reactive for HAV IgM and IgG when tested. A panel of 40 ORF samples from persons known to have been uninfected were all unreactive. Two hundred and eighty household contacts of 72 index cases were screened by ORF to identify HAV transmission within the family and factors associated with household transmission. Almost half of households (35/72) revealed evidence of recent infection, which was significantly associated with the presence of children ⩽11 years of age (odds ratio 9.84, 95% confidence interval: 2.74–35.37). These HAV IgM and IgG immunoassays are easy to perform, rapid and sensitive and have been integrated into national guidance on the management of hepatitis A cases.
Decomposing edge-coloured graphs under colour degree constraints
Authors: Fujita Shinya , Li Ruonan , Wang Guanghui 
Published: March 2019

AbstractFor an edge-coloured graph G, the minimum colour degree of G means the minimum number of colours on edges which are incident to each vertex of G. We prove that if G is an edge-coloured graph with minimum colour degree at least 5, then V(G) can be partitioned into two parts such that each part induces a subgraph with minimum colour degree at least 2. We show this theorem by proving amuch stronger form. Moreover, we point out an important relationship between our theorem and Bermond and Thomassen’s conjecture in digraphs.
ENFORCEABLE OPERATOR ALGEBRAS
Authors: Goldbring Isaac 
Published: March 2019

AbstractWe adapt the classical notion of building models by games to the setting of continuous model theory. As an application, we study to what extent canonical operator algebras are enforceable models. For example, we show that the hyperfinite II1 factor is an enforceable II1 factor if and only if the Connes Embedding Problem has a positive solution. We also show that the set of continuous functions on the pseudoarc is an enforceable model of the theory of unital, projectionless, abelian $\text{C}^{\ast }$-algebras and use this to show that it is the prime model of its theory.
Psychological Detachment from Work during Nonwork Time and Employee Well-Being: The Role of Leader’s Detachment
Authors: Sonnentag Sabine , Schiffner Caterina 
Published: March 2019

AbstractResearch has shown that psychological detachment from work during nonwork time is an important recovery experience and is crucial for employee well-being. Integrating research on job-stress recovery with research on leadership and employee mental health and well-being, this study examines how a leader’s psychological detachment from work during nonwork time directly relates to subordinate psychological detachment from work and indirectly to employee exhaustion and need for recovery. Based on self-report data from 137 employees and their supervisors, this study revealed that leader psychological detachment was related to subordinate psychological detachment and that leader psychological detachment was indirectly related to low subordinate exhaustion and low subordinate need for recovery, also when controlling for negative affectivity and leader-member-exchange. Overall, this study demonstrates that leaders might have an impact on subordinate strain symptoms not only via leadership behavior at work but also via detachment processes during leisure time. These findings suggest that employee recovery processes might not only be regarded as an individual phenomenon, but could be seen as embedded in the larger organizational context.
Exploring the Relationship of a Gamified Assessment with Performance
Authors: Nikolaou Ioannis , Georgiou Konstantina , Kotsasarlidou Vasiliki 
Published: March 2019

AbstractOur study explores the validity of a game-based assessment method assessing candidates’ soft skills. Using self-reported measures of performance, (job performance, Organizational Citizenship Behaviors (OCBs), and Great Point Average (GPA), we examined the criterion-related and incremental validity of a game-based assessment, above and beyond the effect of cognitive ability and personality. Our findings indicate that a game-based assessment measuring soft skills (adaptability, flexibility, resilience and decision making) can predict self-reported job and academic performance. Moreover, a game-based assessment can predict academic performance above and beyond personality and cognitive ability tests. The effectiveness of gamification in personnel selection is discussed along with research and practical implications introducing recruiters and HR professionals to an innovative selection technique.
A Perspective on the Legacy of Edward Lorenz
Authors: McWilliams James C. 
Published: March 2019

Edward Lorenz published research papers over a period of 58 years on a variety of subjects encompassed within dynamical meteorology. A commentary is presented here on four of his most important ideas: available potential energy in the atmospheric general circulation, chaotic dynamics, limits of weather predictability, and the hypothesized slow manifold of momentum‐balanced evolution free of fast oscillations.
Evolution of Large‐Scale Magnetic Fields From Near‐Earth Space During the Last 11 Solar Cycles
Authors: Pick Leonie , Korte Monika , Thomas Yannik , Krivova Natalie , Wu Chi‐Ju 
Published: March 2019

AbstractWe use hourly mean magnetic field measurements from 34 midlatitude geomagnetic observatories between 1900 and 2015 to investigate the long‐term evolution and driving mechanism of the large‐scale external magnetic field at ground. The Hourly Magnetospheric Currents index (HMC) is derived as a refinement of the Annual Magnetospheric Currents index (HMC, Pick & Korte, 2017, https://doi.org/10.1093/gji/ggx367). HMC requires an extensive revision of the observatory hourly means. It depends on three third party geomagnetic field models used to eliminate the core, the crustal, and the ionospheric solar‐quiet field contributions. We mitigate the dependency of HMC on the core field model by subtracting only nondipolar components of the model from the data. The separation of the residual (dipolar) signal into internal and external (HMC) parts is the main methodological challenge. Observatory crustal biases are updated with respect to AMC, and the solar‐quiet field estimation is extended to the past based on a reconstruction of solar radio flux (F10.7). We find that HMC has more power at low frequencies (periods ≥ 1 year) than the Dcx index, especially at periods relevant to the solar cycle. Most of the slow variations in HMC can be explained by the open solar magnetic flux. There is a weakly decreasing linear trend in absolute HMC from 1900 to present, which depends sensitively on the data rejection criteria at early years. HMC is well suited for studying long‐term variations of the geomagnetic field.
Quantifying the Value of Real‐Time Geodetic Constraints for Earthquake Early Warning Using a Global Seismic and Geodetic Data Set
Authors: Ruhl C. J. , Melgar D. , Chung A. I. , Grapenthin R. , Allen R. M. 
Published: March 2019

AbstractGeodetic earthquake early warning (EEW) algorithms complement point‐source seismic systems by estimating fault‐finiteness and unsaturated moment magnitude for the largest, most damaging earthquakes. Because such earthquakes are rare, it has been difficult to demonstrate that geodetic warnings improve ground motion estimation significantly. Here, we quantify and compare timeliness and accuracy of magnitude and ground motion estimates in simulated real time from seismic and geodetic observations for a suite of globally distributed, large earthquakes. Magnitude solutions saturate for the seismic EEW algorithm (we use ElarmS) while the ElarmS‐triggered Geodetic Alarm System (G‐larmS) reduces the error even for its first solutions. Shaking intensity (Modified Mercalli Intensity, MMI) time series calculated for each station and each event are assessed based on MMI threshold crossings, allowing us to accurately characterize warning times per station. We classify alerts and find that MMI 4 thresholds result in true positive alerts for 11.2% of sites exceeding MMI 4 with a median warning time of 20.1 s for ElarmS, while G‐larmS issues true positive alerts for 20.9% of all sites exceeding MMI 4 with a significantly longer median warning time of 34.2 s. The geodetic EEW system reduces the number of missed alerts for a threshold of MMI 4 from 20.5% to 10.8% for all sites, but also increases the number of false positive alerts from 1.6% to 19.9% of all sites. By quantifying increased accuracy in magnitude, ground motion estimation, and alert timeliness, we demonstrate that finite‐fault geodetic algorithms add significant value, including better cost savings performance, to point‐source seismic EEW systems for large earthquakes.
A Deep Eastern Boundary Current Carrying Indian Deep Water South of Australia
Authors: Tamsitt V. , Talley L. D. , Mazloff M. R. 
Published: March 2019

AbstractIn the Southern Hemisphere, the ocean's deep waters are predominantly transported from low to high latitudes via boundary currents. In addition to the Deep Western Boundary Currents, pathways along the eastern boundaries of the southern Atlantic, Indian, and Pacific transport deep water poleward into the Southern Ocean where these waters upwell to the sea surface. These deep eastern boundary currents and their physical drivers are not well characterized, particularly those carrying carbon and nutrient‐rich deep waters from the Indian and Pacific basins. Here we describe the poleward deep eastern boundary current that carries Indian Deep Water along the southern boundary of Australia to the Southern Ocean using a combination of hydrographic observations and Lagrangian experiments in an eddy‐permitting ocean state estimate. We find strong evidence for a deep boundary current carrying the low‐oxygen, carbon‐rich signature of Indian Deep Water extending between 1,500 and 3,000 m along the Australian continental slope, from 30°S to the Antarctic Circumpolar Current southwest of Tasmania. From the Lagrangian particles it is estimated that this pathway transports approximately 5.8 ± 1.3 Sv southward from 30°S to the northern boundary of the Antarctic Circumpolar Current. The volume transport of this pathway is highly variable and is closely correlated with the overlying westward volume transport of the Flinders Current.
Propagating Modes of Variability and Their Impact on the Western Boundary Current in the South Atlantic
Authors: Majumder Sudip , Goes Marlos , Polito Paulo S. , Lumpkin Rick , Schmid Claudia , Lopez Hosmay 
Published: March 2019

AbstractStudies have suggested that the South Atlantic Ocean plays an important role in modulating climate at global and regional scales and thus could serve as a potential predictor of extreme rainfall and temperature events globally. To understand how propagating modes of variability influence the circulation of the subtropical gyre and the southward flowing Brazil Current (BC) at interannual frequencies, a Complex Empirical Orthogonal Function (CEOF) analysis was performed on the satellite‐derived sea surface height (SSH). The first three CEOF modes explain about 23%, 16%, and 11% of the total interannual variability and show clear westward propagation with phase speeds comparable to that of theoretical baroclinic mode 1 Rossby waves. Results suggest that there is a change in the way energy is distributed among the modes before and after 2005. Before 2005, the SSH variability in the western boundary in the South Atlantic and the volume transport of the BC are more closely linked to the first and the second modes, while the third mode dominates after 2005. This change in energy distribution around 2005 is associated with the recent El Niño‐Southern Oscillation (ENSO) regime shift in the Pacific Ocean via atmospheric teleconnections. We found that the first CEOF mode is strongly correlated with eastern Pacific (i.e., canonical) ENSO events and the Pacific Decadal Oscillation, whereas the third CEOF is correlated to central Pacific (i.e., Modoki) ENSO. These results are useful to understand the overall dynamics of the South Atlantic and to potentially improve predictability of Meridional Overturning Circulation and monsoon pattern changes around the world.
Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
Authors: Ionescu Ariel , Gradus Tal , Altman Topaz , Maimon Roy , Saraf Avraham Noi , Geva Michal , Hayden Michael , Perlson Eran 
Published: March 2019

AbstractAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early pathological events in ALS include perturbations in axonal transport (AT), formation of toxic protein aggregates and Neuromuscular Junction (NMJ) disruption, which all lead to axonal degeneration and motor neuron death. Pridopidine is a small molecule that has been clinically developed for Huntington disease. Here we tested the efficacy of pridopidine for ALS using in vitro and in vivo models. Pridopidine beneficially modulates AT deficits and diminishes NMJ disruption, as well as motor neuron death in SOD1G93A MNs and in neuromuscular co-cultures. Furthermore, we demonstrate that pridopidine activates the ERK pathway and mediates its beneficial effects through the sigma-1 receptor (S1R). Strikingly, in vivo evaluation of pridopidine in SOD1G93A mice reveals a profound reduction in mutant SOD1 aggregation in the spinal cord, and attenuation of NMJ disruption, as well as subsequent muscle wasting. Taken together, we demonstrate for the first time that pridopidine improves several cellular and histological hallmark pathologies of ALS through the S1R.
Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
Authors: Li Yang I. , Wong Garrett , Humphrey Jack , Raj Towfique 
Published: March 2019

AbstractGenome-wide association studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson’s Disease (PD) but identifying putative causal genes and the underlying mechanisms remains challenging. Here, we leverage large-scale transcriptomic datasets to prioritize genes that are likely to affect PD by using a transcriptome-wide association study (TWAS) approach. Using this approach, we identify 66 gene associations whose predicted expression or splicing levels in dorsolateral prefrontal cortex (DLFPC) and peripheral monocytes are significantly associated with PD risk. We uncover many novel genes associated with PD but also novel mechanisms for known associations such as MAPT, for which we find that variation in exon 3 splicing explains the common genetic association. Genes identified in our analyses belong to the same or related pathways including lysosomal and innate immune function. Overall, our study provides a strong foundation for further mechanistic studies that will elucidate the molecular drivers of PD.
Author Correction: Bottom-up synthesis of chiral covalent organic frameworks and their bound capillaries for chiral separation
Authors: Qian Hai-Long , Yang Cheng-Xiong , Yan Xiu-Ping 
Published: March 2019

This Article contains an error in Fig. 1, in which the structures of ‘(+)-Ac-L-Ta’ and ‘CTp’ are drawn incorrectly. The correct version of Fig. 1 is shown below. The error has not been fixed in the original PDF and HTML versions of the Article.