bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a risk screening tool for pediatric type 1 diabetes patients: a predictor of increased acute health care utilization
Authors: Glick Bethany A. , Hong K. Ming Chan , Buckingham Don , Moore-Clingenpeel Melissa , Salvator Ann , Kamboj Manmohan K. 
Published: September 2019

Abstract

Background
Both psychosocial and socioeconomic risk factors contribute to poor glycemic control (GC). Previous research has identified that diabetes care behaviors are generally ‘set’ by late childhood, further highlighting the importance of psychosocial screening and intervention in the early course of disease management. The purpose of the current study was to determine whether this brief risk assessment tool is associated with GC and acute health care (HC) utilization, and to evaluate the discriminatory utility of the tool for predicting poor outcomes.

Methods
This was a retrospective cohort design in which we compared risk assessment scores with health outcomes at 6, 12, and 18 months after new-onset type 1 diabetes diagnosis for 158 patients between 2015 and 2017. The two primary outcome variables were GC and acute HC utilization.

Results
Our data demonstrate that the greatest utility of the tool is for predicting increased acute HC utilization. It was most useful in differentiating between patients with vs. without any acute HC utilization, with excellent discriminatory ability (area under the receiver operator characteristic curve [AUC] = 0.93), sensitivity (90%), and specificity (97%).

Conclusions
Knowledge of the risk category in addition to identification of individual risk factors within each domain allows for not only clear treatment pathways but also individualized interventions. The risk assessment tool was less effective at differentiating patients with poor GC; however, the tool did have high specificity (83%) for predicting poor GC at 18 months which suggests that the tool may also be useful for predicting patients at risk for poor GC.
Die Zeit der Einbildungskraft - Die Rolle des Schematismus in Kants Erkenntnistheorie
Authors: Schäfer Rainer 
Published: September 2019

Abstract
In this paper, I focus on Kant’s doctrine of figurative synthesis. Figurative synthesis is the result of the activity of productive transcendental imagination. This is the chief problem of the so-called “second proof step” in Kant’s deduction of the categories according to the second edition of the Critique of Pure Reason. The pure original synthetic apperception forms in the inner and outer sense - i. e. in time and space - by self-affection structures of order that make it possible to cognize empirical objects. The order of space and time through figurative syntheses (formal intuitions) must be distinguished on the one hand from space and time as forms of intuition and on the other hand from the order of the manifold given in space and time (intuition of particular contents). This clarifies the differences and relations between the constitutive noetic faculties of our knowledge apparatus.
Kant On Temporal Extension: Embodied, Indexical Idealism
Authors: Wyller Truls 
Published: September 2019

Abstract
I defend what I take to be a genuinely Kantian view on temporal extension: time is not an object but a human horizon of concrete particulars. As such, time depends on the existence of embodied human subjects. It does not, however, depend on those subjects determined as spatial objects. Starting with a realist notion of “apperception” as applied to indexical space (1), I proceed with the need for external criteria of temporal duration (2). In accordance with Kant’s Second Analogy of Experience, these criteria are found in concepts and laws of motion and change (3). I then see what follows from this for a reasonable notion of transcendental idealism (4). Finally, in support of my Kantian conclusions, I argue for the transcendentally subjective nature of particular temporal extension (5).
Using the humanoid robot Kaspar in a Greek school environment to support children with Autism Spectrum Condition
Authors: Karakosta Efstathia , Dautenhahn Kerstin , Syrdal Dag Sverre , Wood Luke Jai , Robins Ben 
Published: September 2019

Abstract
Previous studies conducted with the humanoid robot Kaspar in the UK have yielded many encouraging results. This paper examines the influence of conducting play sessions with Kaspar on the social and communication skills of children diagnosed with Autism Spectrum Condition (ASC) and suggests possible ways for using the robot as a (therapeutic) tool in a Greek school for children with special needs. Over a period of 10 weeks 7 children took part in a total of 111 individual play sessions with the Kaspar robot. Each child participated in between 12 and 18 sessions with the robot. The results from this study indicate that the play sessions with Kaspar appear to have positively influenced the behaviours of some of the children in specific domains such as communication and interaction, prompted speech, unprompted imitation and focus/attention. Furthermore, the children’s teachers expressed positive views regarding the impact of the play sessions on the children and offered interesting suggestions about the ways in which the robot could potentially be used in everyday teaching tasks and were eager to obtain a Kaspar for their classroom activities.
Surface damage characterization of photodegraded low-density polyethylene by means of friction measurements
Authors: Igarashi Toshio , Ohno Soichiro , Oda Sayaka , Hirosawa Satoru , Hiejima Yusuke , Nitta Koh-hei 
Published: September 2019

Abstract
Friction measurements have been carried out to characterize surface damages during photodegradation of low-density polyethylene. The average and mean deviation of the friction coefficients increase with the irradiation time in the early stage of photodegradation processes, indicating the increase in the surface roughness, whereas the mechanical properties remain essentially unchanged. In the following stage, where the ductile-brittle transition takes place, the mean deviation of the friction coefficients shows an appreciable decrease with maintaining almost constant average values, suggesting that the surface becomes more homogeneous. Beyond the ductile-brittle transition, both of the average and mean deviation of the friction coefficients gradually increase with the irradiation time, indicating further enhancement of surface roughness, followed by formation of surface cracks. The soundness of the friction measurements is confirmed by comparing with optical measurements of the surface roughness, and it is suggested that the present method gives a convenient and sensitive method of detection for degradation in polymeric materials.
A data-driven computational semiotics: The semantic vector space of Magritte’s artworks
Authors: Chartier Jean-François , Pulizzotto Davide , Chartrand Louis , Meunier Jean-Guy 
Published: September 2019

Abstract
The rise of big digital data is changing the framework within which linguists, sociologists, anthropologists, and other researchers are working. Semiotics is not spared by this paradigm shift. A data-driven computational semiotics is the study with an intensive use of computational methods of patterns in human-created contents related to semiotic phenomena. One of the most promising frameworks in this research program is the Semantic Vector Space (SVS) models and their methods. The objective of this article is to contribute to the exploration of the SVS for a computational semiotics by showing what types of semiotic analysis can be accomplished within this framework. The study is applied to a unique body of digitized artworks. We conducted three short experiments in which we explore three types of semiotic analysis: paradigmatic analysis, componential analysis, and topic modelling analysis. The results reported show that the SVS constitutes a powerful framework within which various types of semiotic analysis can be carried out.
Big Data and Trust in Public Policy Automation
Authors: Waggoner Philip D. , Kennedy Ryan , Le Hayden , Shiran Myriam 
Published: September 2019

AbstractBig data is everywhere, both in and out of public policy. Though a rich data source, what is the impact of big data beyond the research community? We suggest such that invoking big data-related terms acts as a heuristic for assumed algorithmic quality. Such an assumption leads to greater trust in automation in public policy decision-making. We test this “big-data-effect” expectation using four tests including a conjoint experiment embedded in a recently fielded survey experiment. We find strong evidence that indeed, big data-related terms act as powerful signals of assumed quality where respondents consistently prefer algorithms with bigger data behind them, absent any mention of predictive accuracy or definitions of key terms (e.g. “training features”). As we expect this big-data-effect is likely not beholden to public policy, we encourage more research in this vein to deepen an understanding of the influence of big data on modern society.
Machine learning in industrial measurement technology for detection of known and unknown faults of equipment and sensors
Authors: Schneider Tizian , Klein Steffen , Schütze Andreas 
Published: September 2019

Abstract
This paper focuses on the application of novelty detection in combination with supervised fault classification for industrial condition monitoring. Its goal is to provide a guideline for engineers on how to apply novelty detection for outlier detection, monitoring of supervised classification and detection of unknown faults without the need of a data scientist. All guidelines are demonstrated by means of a publicly available condition monitoring dataset. In each application case the results achieved with different common novelty detection algorithms are compared, advantages and disadvantages of the respective algorithms are shown. To increase applicability of the suggested approach visualization of results is emphasized and all algorithms have been included in a publicly available data analysis software toolbox with graphical user interface.
The Effect of the Circumferential Position of Duct Hole on the Non-uniformity in the Axial Compressor
Authors: Gong Yun , Chen Shaowen , Wang Songtao 
Published: September 2019

Abstract
The bleeding air flow increases so as to meet the demand of higher efficiency and better performance of compressor, and the issues brought by the bleeding system is of great interest for more and more researchers. In the opened literature, most of the works were performed through single-passage calculations. However, the non-uniformity caused by the bleeding system lead to an undesirable effect on the compressor, thus the multi-passage calculations should taken into consideration. In the present study, the annulus cascade and bleeding system were numerical studied on ANSYS CFX to investigate the effect of the circumferential position of the bleeding duct holes on the non-uniformity in the compressor and to make it clear that how the non-uniformity is formed. Finally, it is found that the unequal air bleeding mass flow rate in different passages result in the non-uniformity in the compressor. The non-uniformity in circumferential position could be alleviated when the duct hole moving toward the suction surface, however, when the duct hole moving toward the pressure surface, the flow separation would be suppressed in more blade passages.
Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw
Authors: Hao Yan , Waller Thomas J. , Nye Derek M. , Li Jiaxing , Zhang Yanxiao , Hume Richard I. , Rolls Melissa M. , Collins Catherine A. 
Published: September 2019

The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report a new regulator of axonal resilience. The transmembrane protein Raw is cell autonomously required for the degeneration of injured axons, dendrites, and synapses inDrosophila melanogaster. In both male and femalerawhypomorphic mutant or knock-down larvae, the degeneration of injured axons, dendrites, and synapses from motoneurons and sensory neurons is strongly inhibited. This protection is insensitive to reduction in the levels of the NAD+synthesis enzyme Nmnat (nicotinamide mononucleotide adenylyl transferase), but requires the c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinase and the transcription factors Fos and Jun (AP-1). Although these factors were previously known to function in axonal injury signaling and regeneration, Raw's function can be genetically separated from other axonal injury responses: Raw does not modulate JNK-dependent axonal injury signaling and regenerative responses, but instead restrains a protective pathway that inhibits the degeneration of axons, dendrites, and synapses. Although protection inrawmutants requires JNK, Fos, and Jun, JNK also promotes axonal degeneration. These findings suggest the existence of multiple independent pathways that share modulation by JNK, Fos, and Jun that influence how axons respond to stress and injury.SIGNIFICANCE STATEMENTAxonal degeneration is a major feature of neuropathies and nerve injuries and occurs via a cell autonomous self-destruction pathway whose mechanism is poorly understood. This study reports the identification of a new regulator of axonal degeneration: the transmembrane protein Raw. Raw regulates a cell autonomous nuclear signaling pathway whose yet unknown downstream effectors protect injured axons, dendrites, and synapses from degenerating. These findings imply that the susceptibility of axons to degeneration is strongly regulated in neurons. Future understanding of the cellular pathway regulated by Raw, which engages the c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinase and Fos and Jun transcription factors, may suggest new strategies to increase the resiliency of axons in debilitating neuropathies.
A somatic mutation in CLCN2 identified in a sporadic aldosterone-producing adenoma
Authors: Dutta Ravi Kumar , Arnesen Thomas , Heie Anette , Walz Martin , Alesina Piero , Söderkvist Peter , Gimm Oliver 
Published: September 2019

Objective
To screen for CLCN2 mutations in apparently sporadic cases of aldosterone-producing adenomas (APAs).

Description
Recently, CLCN2, encoding for the voltage-gated chloride channel protein 2 (ClC-2), was identified to be mutated in familial hyperaldosteronism II (FH II). So far, somatic mutations in CLCN2 have not been reported in sporadic cases of APAs. We screened 80 apparently sporadic APAs for mutations in CLCN2. One somatic mutation was identified at p.Gly24Asp in CLCN2. The male patient had a small adenoma in size but high aldosterone levels preoperatively. Postoperatively, the patient had normal aldosterone levels and was clinically cured.

Conclusion
In this study, we identified a CLCN2 mutation in a sporadic APA comprising about 1% of all APAs investigated. This mutation was complementary to mutations in other susceptibility genes for sporadic APAs and may thus be a driving mutation in APA formation.
Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism
Authors: Wisidagama Dona R , Thummel Carl S 
Published: September 2019

Abstract
Multiple signaling pathways in the adult Drosophila enterocyte sense cellular damage or stress and signal to intestinal stem cells (ISCs) to undergo proliferation and differentiation, thereby maintaining intestinal homeostasis. Here we show that misregulation of mitochondrial pyruvate metabolism in enterocytes can stimulate ISC proliferation and differentiation. Our studies focus on the Mitochondrial Pyruvate Carrier (MPC), which is an evolutionarily-conserved protein complex that resides in the inner mitochondrial membrane and transports cytoplasmic pyruvate into the mitochondrial matrix. Loss of MPC function in enterocytes induces Unpaired cytokine expression, which activates the JAK/STAT pathway in ISCs, promoting their proliferation. Upd3 and JNK signaling are required in enterocytes for ISC proliferation, indicating that this reflects a canonical non-cell autonomous damage response. Disruption of lactate dehydrogenase in enterocytes has no effect on ISC proliferation but it suppresses the proliferative response to a loss of enterocyte MPC function, suggesting that lactate contributes to this pathway. These studies define an important role for cellular pyruvate metabolism in differentiated enterocytes to maintain stem cell proliferation rates.
Doctrinal problems of the municipal statute norm-setting (axiological, ontological and teleological aspects)
Authors: Батанов O. В. , Кравченко В. В. 
Published: September 2019

The article is devoted to the conceptual problems of statutory rulemaking in local self-government. Conceptual analysis of axiological aspects of municipal statute norm-making is carried out. There is a connection with the axiology of the municipal statute law of the problem of its ontological significance. It is substantiated that the disclosure of ontological aspects of municipal statutory rulemaking will show the role of territorial communities as a special form of law in terms of the embodiment of the ideals of municipal democracy as a person, a member of a territorial community. The essential features and substantiated structural, informative and functional characteristics of the institute of statutory law in the local self-government are revealed. Attention is drawn to the coordination-integration and orientation-coordination value of the municipal statutory norm-setting. Established sources and forms of statutory law in local self-government and substantiated the basic organizational and legal patterns of its development. The system of functions of the statutory right, to which the authors include such as: legitimate, managerial, regulatory, innovative, reformatory, right of establishment, human rights, ethics are given.
It is concluded that an important criterion for determining the effectiveness of the statutes of territorial communities and the system of their functions, their social value is the effectiveness of the implementation of these functions in order to fulfill the tasks and objectives laid down in the municipal statutory regulation. Municipal statutory law - nothing if its provisions are not implemented in the activities of territorial communities and their members – the inhabitants of villages, settlements and cities, in municipal-legal relations. It is impossible to understand the value, essence, content, functional and teleological purpose of municipal law, if we deviate from the mechanism of its realization in the life of a society of specific territorial communities. This statement, first of all, should be attributed to the assessment of the statutes of territorial communities, their norms and functions. In other words, the statutes of territorial communities remain completely ineffective documents, and their prescriptions – abstraction, devoid of real meaning and practical significance, in the case where, firstly, the adoption of the statutes of territorial communities did not have objective preconditions; and secondly, the statutes of territorial communities do not have a real impact on social relations in the field of local self-government. Therefore, the effectiveness of the existence and functioning of the statutes of territorial communities and their normative requirements is determined by the degree of their implementation.
Organizational and legal principles of application of media in the system of public administration
Authors: Бородін Є. Є. 
Published: September 2019

The article analyzes the organizational and legal grounds for using the procedure of mediation in the system of public administration in Ukraine. The author examines the evolution of the legal and regulatory framework for the implementation of the mediation institute. According to the author, the priority direction of the development of mediation is its application as an independent form of public litigation settlement, which exists along with other ways of protecting civil rights. In this case, we are talking about mediation as an integral part of a unified system of regulation and resolution of legal disputes by public administration.
The purpose of the article is to study the organizational and legal grounds for the introduction of mediation in the system of public administration. The author analyzes the foreign experience of the organization and regulation of private mediation and highlights the following models: a "market" approach where mediation is considered as a service provided by individuals and organizations mainly on a commercial basis; public-law approach, when mediation is considered as one of the types of professional activity, to a certain extent controlled by the state; self-regulation approach, when mediation is also considered as one of the types of professional activity, but the establishment and monitoring of standards is carried out by the professional community of mediators. It is concluded that self-regulation is the most rational approach to organizing a mediation institution that responds both to public and public interests. Thus, the objectives of regulatory regulation should be limited to the recognition of mediation as an independent way of resolving legal disputes, the creation of legal conditions and the establishment of certain benchmarks for the further development and improvement of this institution.
Implementation of international standards in local government as a key to sustainable development
Authors: Бортнік О. В. 
Published: September 2019

The article deals with the most relevant international standards created to promote the developmentand increase the efficiency of local government structures. The works of domestic and foreign authors isanalyzed, defining the role of the local government potential in ensuring sustainable development of theregions. The link between UN global goals and the standards adopted by the International Organizationfor Standardization for sustainable development is analysed. Were taken into consideration the standardsconnected with work of local government authorities: ISO 9001:2015 «Quality management systems –Requirements», ISO 18091:2019 «Quality management systems – Guidelines for the application of ISO9001 in local government», ISO 37120:2018 «Sustainable cities and communities – Indicators for cityservices and quality of life», ISO 31000 «Risk Management – Guidelines», IEC 31010 «Risk Management– Risk Assessment Techniques», ISO 22301:2012 «Societal security – Business continuity managementsystems – Requirements», ISO 20121:2012 «Event sustainability management systems – Requirementswith guidance for use». Presented opinion about relevance of the seven quality management principles to local government and degree of their implementation in local government in Ukraine. The key features ofthese standards and their role in improving the quality of life of the population and the efficiency of thework of local government bodies are considered. Examples of quality management systems implementationexperience in local government abroad (based on Italian research) and feedback on the results are provided.Provided examples and explanation of city indicators according to ISO 37120. And how standards canhelp prepare and respond properly in the most unpredictable situations, contribute to effective disaster riskmanagement through the provision of universal tools and mechanisms at the city, state and regional levels ofgovernment. The possibilities of applying international practice in Ukraine are considered and importanceof international standards’ implementation in local government as a key to sustainable development wereexamined.