bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worth a thousand words? Visual concept mapping of the quality of life of people with severe mental health problems
Authors: Buitenweg David C. , Bongers Ilja L. , van de Mheen Dike , van Oers Hans A.M. , Van Nieuwenhuizen Chijs 
Published: May 2018

AbstractObjectivesConventional approaches to quality of life (QoL) measurement rely heavily on verbal, language‐based communication. They require respondents to have significant cognitive and verbal ability, making them potentially unsuitable for people with severe mental health problems. To facilitate an alternative approach to QoL assessment, the current study aims to develop an alternative, visual representation of QoL for people with severe mental health problems.MethodsAn alternative, visual adaptation of the concept mapping method was used to construct this visual representation of QoL. Eighty‐two participants (i.e., patients, care professionals, and family members) contributed to this study. Results were processed statistically to construct the concept map.ResultsThe concept map contains 160 unique visual statements, grouped into 8 clusters labelled (1) Support and Attention, (2) Social Contacts, (3) Happiness and Love, (4) Relaxation and Harmony, (5) Leisure, (6) Lifestyle, (7) Finances, and (8) Health and Living. Examples of visual statements are pictures of family silhouettes, romantic couples, natural scenes, houses, sports activities, wallets and coins, smiley faces, and heart shapes. The clusters were interpreted and labelled by participants.ConclusionsAlmost all of the statements correspond to clusters found in previous (non‐visual) QoL research. Hence, QoL domains can also be presented visually.
A prospective naturalistic multicenter study on choice of parenteral medication in psychiatric emergency settings in Japan
Authors: Hatta Kotaro , Katayama Shigemasa , Morikawa Fumiyoshi , Imai Atsushi , Fujita Kiyoshi , Fujita Aiko , Ishizuka Takuya , Abe Takayuki , Sudo Yasuhiko , Hashimoto Kijiro , Usui Chie , Nakamura Hiroyuki , Yamanouchi Yoshio , Hirata Toyoaki ,   the JAST study group
Published: May 2018

AbstractAimTo provide information about psychiatric emergency situations in Japan, we examined psychiatrists’ preference among parenteral medication since intramuscular (IM)‐olanzapine became available and clinical characteristics in patients given IM‐olanzapine compared to those given other parenteral medication.MethodsWe conducted a naturalistic study proceeding over a 1‐year period in 9 psychiatric emergency departments.ResultsAmong 197 patients, the distribution of IM‐injections (n = 89) was as follows: IM‐olanzapine, 66 patients (74.2%), IM‐levomepromazine, 17 patients (19.1%), IM‐haloperidol, 5 patients (5.6%), and IM‐diazepam, 1 patient (1.1%). The distribution of intravenous (IV)‐injections (n = 108) was as follows: IV‐haloperidol, 78 patients (72.2%), and IV‐benzodiazepines (diazepam, flunitrazepam, or midazolam), 30 patients (27.8%). Advantages of IM‐olanzapine over other parenteral medications in efficacy were found as follows: less frequent needs of an additional injection despite no difference in duration until a patient became cooperative for oral administration, and less frequent needs of restraint after the injection. Furthermore, advantages of IM‐olanzapine over other injections in safety were found as follows: less frequent appearance of extrapyramidal symptoms, no occurrence of ECG abnormality and other serious adverse events except a fall, less frequent needs of an adjunctive anticholinergic drug, and less frequent needs of another kind of drug additionally injected.ConclusionsOlanzapine has rapidly become the first choice of intramuscular medication in psychiatric emergency situations since it became available in Japan, probably due to the advantages in both efficacy and safety. This study reflecting psychiatric emergency practice in Japan may contribute to periodic international comparison of psychiatric emergency practice.
Longitudinal reference ranges for serial measurements of myocardial performance index (MPI) by conventional and pulsed‐wave tissue Doppler in monochorionic diamniotic twins at 17 to 26 weeks of gestation
Authors: Zanardini Cristina , Fichera Anna , Calza Stefano , Cappa Veronica , Orabona Rossana , Frusca Tiziana , Prefumo Federico 
Published: May 2018

AbstractObjectiveTo describe the longitudinal changes of fetal myocardial performance index (MPI) measured by conventional Doppler (MPI) and by pulsed‐wave tissue Doppler (MPI′) based on a prospective cohort of uncomplicated monochorionic diamniotic twin.MethodSingle‐center observational study. We measured MPI and MPI′ in the right and left ventricles 3 times between 17 and 26 weeks of gestation. Second‐degree fractional polynomials were built to obtain the best fitting curves in relation to gestational age (weeks) for each parameter. Gestational age‐specific reference values were estimated by using two‐level hierarchical models.ResultsEighty‐three uncomplicated monochorionic pregnancies were included in our study with a total of 249 observations. Fetal cardiac function was measured as MPI RV and LV, MPI′ RV and LV at a mean gestational age of 18+3 (range 17+1 to 19+2), 22+3 (21+1 to 23+5), and 24+3 (22+6 to 26+2) weeks. The reference ranges for MPI LV, MPI RV, MPI′ LV, and MPI′ RV at 17 to 26 weeks were constructed and conditional percentiles calculated.ConclusionThe present study provides additional data on fetal cardiac function in uncomplicated monochorionic diamniotic twin gestations, describing the evolution of MPI and MPI′ in both ventricles in uncomplicated monochorionic diamniotic pregnancies.
Use and Incidence of Adverse Effects of Proton Pump Inhibitors in Patients with Cystic Fibrosis
Authors: McCrory Bradley E. , Harper Heidi N. , McPhail Gary L. 
Published: May 2018

PurposeTo evaluate the incidence of adverse effects associated with chronic proton pump inhibitor (PPI) use as well as the dosing, indication, and duration of use of PPIs in the cystic fibrosis (CF) population at a pediatric academic medical center.MethodsStudy design was a retrospective chart review evaluating patients with CF who were prescribed a PPI for at least 6 months (PPI group) or patients with CF who had never been prescribed a PPI (control group) from June 1, 2014, to May 31, 2015.ResultsThe study enrolled 126 patients in the PPI group and 49 patients in the control group. Forty‐four patients (34.9%) had an indication for both gastroesophageal reflux and enzyme enhancement, with an average PPI daily dose of 1 mg/kg/day. Twenty‐one patients (16.7%) in the PPI group had an incidence of hypomagnesemia compared with one patient (2%) in the control group (p=0.097). Overall, 75 patients (59.6%) receiving chronic PPI therapy had at least one pulmonary exacerbation compared with 12 patients (24.5%) in the control group (p<0.001). No significant difference was noted in the incidence of hypocalcemia, low bone mineral density, or positive Clostridium difficile toxin between the two groups.ConclusionThe PPI group had a higher risk of pulmonary exacerbation compared with the control group. Further studies are needed to assess adverse effects associated with chronic PPI use in patients with CF.
Olfactory co‐receptor Orco stimulated by Rice stripe virus is essential for host seeking behavior in small brown planthopper
Authors: Li Shuo , Zhou Changwei , Zhou Yijun 
Published: May 2018

AbstractBACKGROUNDLaodelphax striatellus, the small brown planthopper (SBPH), is an economically important pest, besides sucking damage, which transmits rice viruses to cause severe damages to rice. In the process of virus transmission, the host orientation behavior of insect is mainly driven by olfaction. In this context, the molecular basis of olfaction in SBPH is of particular interest.RESULTSHere, we identified the gene that encodes olfactory receptor co‐receptor (Orco) and analyzed its expression profiles in Rice stripe virus (RSV)‐infected and RSV‐free SBPH. It was found that LstrOrco shared high identity with other Orcos from different order insects. LstrOrco was mainly expressed in the head of SBPH, and its expression was significantly stimulated by RSV‐infection. The behavioral bioassay revealed that viruliferous SBPH might have a stronger olfactory and seeking ability for rice than RSV‐free insect. After silencing of LstrOrco expression, the olfaction and seeking behavior of nymphs for rice seedlings was significantly inhibited, mainly in the increase of the ‘no response’ percent and the prolongation of the response time.CONCLUSIONThese results suggested that Orco played an important role in olfactory signaling and seeking behavior of SBPH, which provided a basic for future development of olfactory‐based agriculture pest management strategies. © 2018 Society of Chemical Industry
Missing data handling in non‐inferiority and equivalence trials: A systematic review
Authors: Rabe Brooke A. , Day Simon , Fiero Mallorie H. , Bell Melanie L. 
Published: May 2018

SummaryBackgroundNon‐inferiority (NI) and equivalence clinical trials test whether a new treatment is therapeutically no worse than, or equivalent to, an existing standard of care. Missing data in clinical trials have been shown to reduce statistical power and potentially bias estimates of effect size; however, in NI and equivalence trials, they present additional issues. For instance, they may decrease sensitivity to differences between treatment groups and bias toward the alternative hypothesis of NI (or equivalence).AimsOur primary aim was to review the extent of and methods for handling missing data (model‐based methods, single imputation, multiple imputation, complete case), the analysis sets used (Intention‐To‐Treat, Per‐Protocol, or both), and whether sensitivity analyses were used to explore departures from assumptions about the missing data.MethodsWe conducted a systematic review of NI and equivalence trials published between May 2015 and April 2016 by searching the PubMed database. Articles were reviewed primarily by 2 reviewers, with 6 articles reviewed by both reviewers to establish consensus.ResultsOf 109 selected articles, 93% reported some missing data in the primary outcome. Among those, 50% reported complete case analysis, and 28% reported single imputation approaches for handling missing data. Only 32% reported conducting analyses of both intention‐to‐treat and per‐protocol populations. Only 11% conducted any sensitivity analyses to test assumptions with respect to missing data.ConclusionMissing data are common in NI and equivalence trials, and they are often handled by methods which may bias estimates and lead to incorrect conclusions.
Improved very short‐term spatio‐temporal wind forecasting using atmospheric regimes
Authors: Browell J. , Drew D. R. , Philippopoulos K. 
Published: May 2018

AbstractWe present a regime‐switching vector autoregressive method for very short‐term wind speed forecasting at multiple locations with regimes based on large‐scale meteorological phenomena. Statistical methods for wind speed forecasting based on recent observations outperform numerical weather prediction for forecast horizons up to a few hours, and the spatio‐temporal interdependency between geographically dispersed locations may be exploited to improve forecast skill. Here, we show that conditioning spatio‐temporal interdependency on “atmospheric modes” derived from gridded numerical weather data can further improve forecast performance. Atmospheric modes are based on the clustering of surface wind and sea‐level pressure fields, and the geopotential height field at the 5000‐hPa level. The data fields are extracted from the MERRA‐2 reanalysis dataset with an hourly temporal resolution over the UK; atmospheric patterns are clustered using self‐organising maps and then grouped further to optimise forecast performance. In a case study based on 6 years of measurements from 23 weather stations in the UK, a set of 3 atmospheric modes are found to be optimal for forecast performance. The skill of 1‐ to 6‐hour‐ahead forecasts is improved at all sites compared with persistence and competitive benchmarks. Across the 23 test sites, 1‐hour‐ahead root mean squared error is reduced by between 0.3% and 4.1% compared with the best performing benchmark and by an average of 1.6% over all sites; the 6‐hour‐ahead accuracy is improved by an average of 3.1%.
Calibration of AGRS System Using Transportable Pads in India: An Application to AGRS Data of Aravalli Basin, Banswada Block, South Rajasthan
Authors: Ramayya M. S. , Chaturvedi A. K. , Parihar P. S. , Sharma P. K. , Jiwane D. U. , Srivastava P. K. , Sunil T. C. 
Published: May 2018

ABSTRACT
Calibration of airborne gamma ray spectrometric system (AGRS) over standard radioactive sources of known elemental abundances is essential before carrying out airborne surveys. In India, fixed calibration pads were constructed in 1985. Since then calibration of AGRS system was carried out over the fixed pads. However the fixed pads are expensive to build and maintain. Also the large pads are subject to variations in radiation output due to variable moisture content and radon loss. Alternate approach is to construct transportable calibration pads which are discussed in this paper.
Atomic Minerals Directorate for Exploration & Research (AMD) under Department of Atomic Energy has recently constructed five transportable calibration pads. Three pads i.e. K, U and Th have been spiked with the respective radioelements while keeping the minor radioelements to the least in order to obtain pure spectra. A composite pad has been constructed which contains all the three radioelements. This helps in cross verifying the obtained calibration results. A background pad has also been constructed which is helpful to obtain the background values during calibration.
Analysis of the data acquired over the transportable pads with airborne gamma ray spectrometer (16.8 ltr) has been carried out and presented in this paper. A comparison with the data acquired over the fixed calibration pads is also included. There is a good agreement of results which suggests the use of transportable pads in future.
Delineation of Fractures through Acoustic Televiewer Log
Authors: Srinivas K. N. S. S. S. , Rao M. Srihari , Kishore P. Pavan , Gopinadh D. , Raza Haris , Arora Kusumita , Satyanarayana H. V. S. 
Published: May 2018

ABSTRACT
Boreholes are the only sources for direct measurements of geological and geophysical characteristics of the shallow sub-surface of the earth. Borehole imaging tool “Acoustic Televiewer (ATV)” is an advanced probe, which records 3D image of the bore hole wall and is used to obtain oriented images of bore hole and provides substantial information regarding lithology, structural information, detection of fractures and casing of the borehole. The images are highly sensitive to the presence of fractures, the delineation of which becomes accurate and reliable based on these acoustic images. Features identified on log-derived images can be correlated with core samples or can be used as substitute in the poor core recovery zones. In the present study, ATV log from a deep borehole drilled at Khadi Kolavan in Koyna-Warna region of Ratnagiri district, Maharashtra located west of the Western Ghat escarpment in the Deccan Volcanic province, India, is used for interpretation of structural characteristics of the formation. The same was correlated with other conventional logging methods such as resistivity and full waveform sonic (FWS) as well as core logging and rock quality designations (RQD) which generated new understanding of the basement and basalt cover in this region.
Implementation of the 2016 WHO CNS Classification for infiltrating glioma: the VGH experience
Authors: Levine A.B. , Yip S. 
Published: May 2018

The classification system for gliomas has undergone significant revisions in the last several years, with the incorporation of molecular criteria and removal of mixed histologic diagnoses. Large-scale molecular studies have elucidated the biological characteristics of low grade gliomas, and enabled grouping based on IDH mutational and 1p19q codeletion status that outperforms histology in predicting patient outcomes. Mutations in ATRX and TP53 are largely mutually exclusive of 1p19q- codeletion in the context of mutant IDH, and are useful in screening patients for further molecular studies.At our institution, new testing methods for 1p19q codeletion and ATRX were implemented in 2014, and in this presentation we review all cases submitted for 1p19q testing since this time. In comparing histologic to molecular diagnoses, the majority of histologic oligodendrogliomas indeed have 1p19q codeletion, while oligoastrocytomas and GBMOs largely are re-classified as astrocytomas and glioblastomas, respectively. We have also found that loss of ATRX nuclear expression associated with ATRX mutation is highly indicative of 1p19q retention, however the immunohistochemical test can be challenging to interpret and there have been a small number of discordant results.
Contribution of chromosome 9p deletion and Bcl1, Myc and p16 immunohistochemistry to the characterization of oligodendrogliomas
Authors: Gould P.V. , Michaud K. , de Tayrac M. , D’Astous M. , Paquet C. , Saikali S. 
Published: May 2018

Molecular studies suggest that anaplastic oligodendrogliomas (OIII) can be subdivided into clinically relevant subgroups. We analyzed a retrospective series of 40 consecutive OIII operated at our institution and compared them to 10 grade II oligodendrogliomas (OII). Chromosome 9p status was compared to Bcl1, Myc and p16 expression by immunohistochemistry, clinical and histological data, and to event free survival (EFS) and overall survival (OS).Chromosome 9p deletion was observed in 55 % of OIII (22/40) but not in OII, and correlated with both OS and EFS. Bcl1 expression was significantly higher in OIII (45 % versus 14% for OII) and correlated with MIB-1 expression, vascular proliferation, tumour necrosis and a shorter EFS. Myc expression was correlated with histologic grade (27% in OII, 35% in OIII) and to a shorter EFS in chromosome 9p non-deleted OIII. p16 expression was not correlated with grade but revealed two distinct expression profiles according to chromosome 9p status. In 9p non-deleted oligodendrogliomas, p16 hyperexpression was correlated with shorter OS in both OII and OIII whereas absence of p16 expression was correlated with shorter OS and EFS in 9p deleted OIII.
Church Missionary Society evangelists and women's labour in nineteenth-century Abẹ́òkúta
Authors: Alanamu Temilola 
Published: May 2018

AbstractThis article is about women's labour in nineteenth-century Abẹ́òkúta, in present-day south-west Nigeria. It is based on primary research which explores women's economic independence and its intricate connection to the indigenous institution of polygyny. By examining the institution from the perspective of Anglican Church Missionary Society evangelists, it also demonstrates how indigenous culture conflicted with the newly introduced Christian religion and its corresponding Victorian bourgeois ideals of the male breadwinner and the female homemaker. It investigates the extent to which missionaries understood women's work in the Yorùbá context, their representations of the practice, their attempts to halt female labour and their often unsuccessful efforts to extricate their congregations and their own families from these local practices. It argues that European Christian principles not only coloured missionary perceptions of women's labour, but influenced their opinions of the entire Yorùbá matrimonial arrangement.
Workspace optimization of a class of zero-torsion parallel wrists
Authors: Wu Yuanqing , Carricato Marco 
Published: May 2018

SUMMARYWe present singularity-free workspace optimization of a class of two-degree-of-freedom (2-DoF) parallel wrists with large rotation range capability. The wrists in consideration are kinematically equivalent to two families of 2-DoF homokinetic couplings. The first family comprises fully parallel wrists withN(N≥ 3) double-universal ($\mathcal{UU}$) legs. The second family comprises sphericalN-$\mathcal{UU}$parallel wrists with interconnecting revolute ($\mathcal{R}$) joints. Both families belong to the more general class of zero-torsion parallel manipulators, and are, therefore, collectively referred to as zero-torsion wrists (ZTWs). We carry out a unified singularity-free workspace optimization by utilizing geometric properties of zero-torsion motion manifolds. Our work may serve as a conceptual guide to the design of ZTWs for large tilt-angle applications.
Transition from blastomere to trophectoderm biopsy: comparing two preimplantation genetic testing for aneuploidies strategies
Authors: Coll Lluc , Parriego Mònica , Boada Montserrat , Devesa Marta , Arroyo Gemma , Rodríguez Ignacio , Coroleu Bonaventura , Vidal Francesca , Veiga Anna 
Published: May 2018

SummaryShortly after the implementation of comprehensive chromosome screening (CCS) techniques for preimplantation genetic testing for aneuploidies (PGT-A), the discussion about the transition from day 3 to blastocyst stage biopsy was initiated. Trophectoderm biopsy with CCS is meant to overcome the limitations of cleavage-stage biopsy and single-cell analysis. The aim of this study was to assess the results obtained in our PGT-A programme after the implementation of this new strategy. Comparisons between the results obtained in 179 PGT-A cycles with day 3 biopsy (D+3) and fresh embryo transfer, and 204 cycles with trophectoderm biopsy and deferred (frozen–thawed) embryo transfer were established. Fewer embryos were biopsied and a higher euploidy rate was observed in the trophectoderm biopsy group. No differences in implantation (50.3% vs. 61.4%) and clinical pregnancy rate per transfer (56.1% vs. 65.3%) were found. Although the mean number of euploid embryos per cycle did not differ between groups (1.5 ± 1.7 vs. 1.7 ± 1.8), the final number of euploid blastocysts available for transfer per cycle was significantly higher in the trophectoderm biopsy group (1.1 ± 1.3 vs. 1.7 ± 1.8). This factor led to an increased cumulative live birth rate in this last group (34.1% vs. 44.6%). Although both strategies can offer good results, trophectoderm biopsy offers a more robust diagnosis and the intervention is less harmful for the embryos so more euploid blastocysts are finally available for transfer and/or vitrification.
Solvency capital requirement and the claims development result
Authors: Munroe D. , Zehnwirth B. , Goldenberg I. 
Published: May 2018

AbstractIn this paper, four variants of calculating the Solvency Capital Requirement for long-tail liabilities satisfying Solvency II regulations are discussed. The merits of each metric are related to the stated objectives of Solvency II. Assumptions made in the calculations are assessed for suitability for the determination of an appropriate level of Solvency Capital. We show that two methods for calculating Solvency Capital provide insufficient capital to restore the Economic Balance Sheet in the event of distress. The standard formula referencing the Claims Development Result is shown to be too conservative when models are correctly specified.