bluuebunny/crossref_metadata_2025_split huggingface dataset:
Octadecyl Amine Functionalized Graphene Oxide towards Hydrophobic Chemical Resistant Epoxy Nanocomposites
Authors: Mousavi Seyyed Mojtaba , Hashemi Seyyed Alireza , Arjmand Mohammad , Amani Ali Mohammad , Sharif Farbod , Jahandideh Sara 
Published: July 2018

AbstractIn this research study, graphene oxide (GO) was synthesized using an improved Hummers method and thence oxygen‐based functional groups were replaced with octadecyl amine. Afterwards, epoxy‐based nanocomposites containing GO and GO‐octadecyl amine (GO‐ODA) were fabricated via a vacuum shock technique. The chemical resistance of the fabricated nanocomposites against various solvents, namely xylene, toluene and distilled water, was investigated and the effect of chemical degradation on the hardness and structural stability of the nanocomposites was examined. Besides, SEM, contact angle and AFM analyses were conducted to evaluate morphology, hydrophobicity and roughness of the nanocomposites prior to and following the chemical degradation. The obtained results illustrated that the reinforcement of the epoxy‐based nanocomposites with GO‐ODA and GO, in order, enhanced chemical resistance, hardness, roughness, and hydrophobicity of the nanocomposites. For instance, after incorporating GO and GO‐ODA into the epoxy resin, the average roughness of the neat epoxy resin reduced 84.0% and 94.1%, the hardness of the neat epoxy resin increased from 80 to 82 and 86 kgf/mm2, and the contact angle of the epoxy resin changed from 76° to 71° and 85°, respectively. In brief, outcome of this study reveals that GO‐ODA can be used as an efficient filler to develop effective hydrophobic polymeric shields against chemical degradation.
A novel reliability analysis approach for component‐based software based on the complex network theory
Authors: Li Kewen , Yu Mingxiao , Liu Lu , Zhai Jiannan , Liu Wenying 
Published: July 2018

SummaryTraditional software reliability evaluation approaches lack the analysis of intercomponent interactions of component‐based software systems, necessitating software reliability evaluation based on the reliabilities of the overall architecture and each component. In this paper, we propose a reliability evaluation model and an importance assessment technique for component‐based software based on the complex network theory. The components of a software system are identified and divided into 2 categories, input/output components and ordinary components. Then, the impact factors of ordinary components and input/output components are calculated based on the complex network theory and execution probabilities, respectively. Finally, the impact factors are used to evaluate the reliability of the software system and assess the importance of each component. Experimental results show that the proposed approach is able to estimate the reliability of component‐based software and provide relative priorities of the components that can be used to guide the system reliability optimization.
A Formalization of the LLL Basis Reduction Algorithm
Authors: Divasón Jose , Joosten Sebastiaan , Thiemann René , Yamada Akihisa 
Published: July 2018

AbstractThe LLL basis reduction algorithm was the first polynomial-time algorithm to compute a reduced basis of a given lattice, and hence also a short vector in the lattice. It thereby approximates an NP-hard problem where the approximation quality solely depends on the dimension of the lattice, but not the lattice itself. The algorithm has several applications in number theory, computer algebra and cryptography.In this paper, we develop the first mechanized soundness proof of the LLL algorithm using Isabelle/HOL. We additionally integrate one application of LLL, namely a verified factorization algorithm for univariate integer polynomials which runs in polynomial time.
Places of Persistence: Slavery and the Geography of Intergenerational Mobility in the United States
Authors: Berger Thor 
Published: July 2018

AbstractIntergenerational mobility has remained stable over recent decades in the United States but varies sharply across the country. In this article, I document that areas with more prevalent slavery by the outbreak of the Civil War exhibit substantially less upward mobility today. I find a negative link between prior slavery and contemporary mobility within states, when controlling for a wide range of historical and contemporary factors including income and inequality, focusing on the historical slave states, using a variety of mobility measures, and when exploiting geographical differences in the suitability for cultivating cotton as an instrument for the prevalence of slavery. As a first step to disentangle the underlying channels of persistence, I examine whether any of the five broad factors highlighted by Chetty et al. (2014a) as the most important correlates of upward mobility—family structure, income inequality, school quality, segregation, and social capital—can account for the link between earlier slavery and current mobility. More fragile family structures in areas where slavery was more prevalent, as reflected in lower marriage rates and a larger share of children living in single-parent households, is seemingly the most relevant to understand why it still shapes the geography of opportunity in the United States.
Evaluation of a Medically Supervised Concussion Protocol for Youth Hockey in Canada
Authors: Ellis Michael J. , Leiter Jeff , Cordingley Dean M. , Reimer Karen , Koenig James , Russell Kelly F. 
Published: July 2018

AbstractObjectives:The objective of this study was to evaluate the feasibility and implementation of a standardized medically supervised concussion protocol established between a city-wide AAA hockey league and a multi-disciplinary concussion program.Methods:We conducted a retrospective review of injury surveillance, clinical and healthcare utilization data from all athletes evaluated and managed through the Winnipeg AAA Hockey concussion protocol during the 2016-2017 season. We also conducted post-season email surveys of head coaches and parents responsible for athletes who competed in the same season.Results:During the 2016-2017 season, 28 athletes were evaluated through the medically supervised concussion protocol, with two athletes undergoing evaluation for repeat injuries (a total of 30 suspected injuries and consultations). In all, 96.7% of the athletes managed through the concussion protocol were captured by the league-designated Concussion Protocol Coordinator and 100% of eligible athletes underwent complete medical follow-up and clearance to return to full hockey activities. Although 90% of responding head coaches and 91% of parents were aware of the concussion protocol, survey results suggest that some athletes who sustained suspected concussions were not managed through the protocol. Head coaches and parents also indicated that athlete education and communication between medical and sport stakeholders were other elements of the concussion protocol that could be improved.Conclusion:Successful implementation of a medically supervised concussion protocol for youth hockey requires clear communication between sport stakeholders and timely access to multi-disciplinary experts in traumatic brain and spine injuries. Standardized concussion protocols for youth sports may benefit from periodic evaluations by sport stakeholders and incorporation of national guideline best practices and resources.
Network Approaches to Understand Individual Differences in Brain Connectivity: Opportunities for Personality Neuroscience
Authors: Tompson Steven H. , Falk Emily B. , Vettel Jean M. , Bassett Danielle S. 
Published: July 2018

AbstractOver the past decade, advances in the interdisciplinary field of network science have provided a framework for understanding the intrinsic structure and function of human brain networks. A particularly fruitful area of this work has focused on patterns of functional connectivity derived from noninvasive neuroimaging techniques such as functional magnetic resonance imaging. An important subset of these efforts has bridged the computational approaches of network science with the rich empirical data and biological hypotheses of neuroscience, and this research has begun to identify features of brain networks that explain individual differences in social, emotional, and cognitive functioning. The most common approach estimates connections assuming a single configuration of edges that is stable across the experimental session. In the literature, this is referred to as a static network approach, and researchers measure static brain networks while a subject is either at rest or performing a cognitively demanding task. Research on social and emotional functioning has primarily focused on linking static brain networks with individual differences, but recent advances have extended this work to examine temporal fluctuations in dynamic brain networks. Mounting evidence suggests that both the strength and flexibility of time-evolving brain networks influence individual differences in executive function, attention, working memory, and learning. In this review, we first examine the current evidence for brain networks involved in cognitive functioning. Then we review some preliminary evidence linking static network properties to individual differences in social and emotional functioning. We then discuss the applicability of emerging dynamic network methods for examining individual differences in social and emotional functioning. We close with an outline of important frontiers at the intersection between network science and neuroscience that will enhance our understanding of the neurobiological underpinnings of social behavior.
The Fixation of (Moral) Belief
Authors: Wilson Nicholas Hoover 
Published: July 2018

AbstractThis article argues that the transition between early-modern and modern organization of empires—especially the administrative outlooks and institutional logics used to govern them—revolved around how moral conflict was viewed within imperial organizations themselves and by metropolitan audiences. Early modern imperial organizations were deeply patrimonial, and hence relied on a style of embedded moral reasoning that distanced and segmented their affairs from the metropole. By contrast, modern empires order what they govern in hierarchies that are nominally objective and whose criteria seem universal. Using a case study of the British Empire’s crisis and transformation at the turn of the 19thcentury, I argue that modern imperial administration emerged because networks of moral justification, which provided the scaffolding for patrimonial early-modern empire, eroded in the face of “disinterested” metropolitan scrutiny. This scrutiny created an audience for bitter political and moral conflicts among imperial administrators, who then used disembedded moral claims to mobilize support.
Automated Fall Detection Technology in Inpatient Geriatric Psychiatry: Nurses’ Perceptions and Lessons Learned
Authors: Coahran Marge , Hillier Loretta M. , Van Bussel Lisa , Black Edward , Churchyard Rebekah , Gutmanis Iris , Ioannou Yani , Michael Kathleen , Ross Tom , Mihailidis Alex 
Published: July 2018

RÉSUMÉLes personnes âgées hospitalisées présentent un haut risque de chute. Le système HELPER est un système de détection des chutes fixé au plafond qui envoie une alerte à un téléphone intelligent lorsqu’une chute est détectée. Cet article décrit la performance du système HELPER, qui a été testé dans un projet pilote mené dans un centre de santé mentale gériatrique. La précision du système pour la détection des chutes a été comparée aux données de l’hôpital liées à la documentation des chutes. Au terme du projet pilote, le personnel infirmier a été interviewé afin de documenter comment cette technologie était perçue. Dans cette étude, le système HELPER n’a pas permis de détecter une chute qui a été documentée par le personnel, mais en a détecté 4 autres qui n’avaient pas été documentées. Bien que la sensibilité du système soit élevée (0.80), les fausses alarmes qu’il génère diminuent sa valeur prédictive (0.01). Les entrevues avec le personnel infirmier ont permis de recueillir plusieurs informations utiles liées au fonctionnement de cette technologie dans un environnement réel; ces données seront utiles aux ingénieurs travaillant sur de tels systèmes et sur des technologies associées aux soins de santé et aux services sociaux.
Human cumulus cell sensitivity to vitrification, an ultrastructural study
Authors: Taghizabet Neda , Khalili Mohammad Ali , Anbari Fatemeh , Agha-Rahimi Azam , Nottola Stefania Annarita , Macchiarelli Guido , Palmerini Maria Grazia 
Published: July 2018

SummaryCumulus cells (CCs) play an important role in the regulation of female gamete development, meiotic maturation, oocyte–sperm interaction, capacitation and acrosome reaction. However, their role in maintaining oocyte competence after vitrification is unclear as controversial data on their protecting action against oocyte cryoinjuries are available. Here we described the effects of vitrification on the ultrastructure of human CCs collected from women undergoing assisted reproductive technologies (ARTs). In total, 50 patches of CCs, sampled from high-quality human cumulus–oocyte complexes, were randomly allocated into two groups after patient informed consent: 1, fresh CCs (controls, n = 25); 2, vitrified CCs (n = 25). Samples were then prepared and observed by transmission electron microscopy. In fresh CCs, in which small cell clusters were visible, cell membranes were joined by focal gap junctions. Microvilli were rare and short. Nuclei, mitochondria, smooth endoplasmic reticulum (SER), Golgi apparatus and lipid droplets appeared well preserved; vacuoles were scarce. After vitrification, we observed two populations of CCs: light CCs, with a smooth appearance and few short microvilli; and dark CCs, with numerous and long microvilli. In both, most of the organelles appeared similar to those of fresh CCs. Lipid droplets were denser and more numerous, with respect to fresh CCs. They were mainly located in the peri-nuclear and sub-plasmalemmal regions. Numerous packed electron-negative vacuoles were visible. The vitrification procedure did not cause alterations in the fine structure of major organelles, except for an increased amount of lipid droplets and vacuoles. This specific sensitivity of human CCs to vitrification should be considered during ARTs.
Fiddling While Rome Burns? A Response to Weyland on Full Professor Promotions
Authors: Leal David L. 
Published: July 2018

ABSTRACTThis article responds to the stimulating comments of Kurt Weyland (2015) about the important but seldom discussed full professor promotion process. He suggested a number of problems, particularly candidates who are too eager to “go up” and institutions with insufficiently rigorous publication standards. Rather than proposing a top-down solution, Weyland urged associate professors to wait until they cleared a high research bar. By contrast, I see few systemic problems with the current promotion process. Although research is important, our academic ecosystem requires the valuing of a wide range of faculty activities and contributions. In addition, asking faculty to jump through even more research hoops may be ‘fiddling while Rome burns.’ It overlooks the crucial issue that we all face: making the case for the value of higher education to taxpayers, parents, lawmakers, students, employers, philanthropists, voters, and society. I am optimistic that we can do so, but it may require a new set of academic priorities—less of the status games that can animate our academic lives and more of a focus on how our work benefits society.
The benefits of international cooperation under climate uncertainty: a dynamic game analysis
Authors: Zhang Xiao-Bing , Hennlock Magnus 
Published: July 2018

AbstractThis paper investigates the benefits of international cooperation under uncertainty about global warming through a stochastic dynamic game. We analyze the benefits of cooperation both for the case of symmetric and asymmetric players. It is shown that the players’ combined expected payoffs decrease as climate uncertainty becomes larger, whether or not they cooperate. However, the benefits from cooperation increase with climate uncertainty. In other words, it is more important to cooperate when facing higher uncertainty. At the same time, more transfers will be needed to ensure stable cooperation among asymmetric players.
Against Conservatism in Metaphysics
Authors: Fairchild Maegan , Hawthorne John 
Published: July 2018

AbstractIn his recent book, Daniel Korman contrasts ontological conservatives with permissivists and eliminativists about ontology. Roughly speaking, conservatives admit the existence of ‘ordinary objects' like trees, dogs, and snowballs, but deny the existence of ‘extraordinary objects', like composites of trees and dogs (‘trogs'). Eliminativists, on the other hand, deny many or all ordinary objects, while permissivists accept both ordinary and extraordinary objects. Our aim in this paper is to outline some of our reasons for being drawn to permissivism, as well as some of our misgivings about conservative metaphysics. In the first section, we discuss a tempting epistemic line of argument against conservatism. This isn’t a line of argument we find especially promising. Our most basic complaint against conservatism is not that conservatism has poor epistemic standing even if true, but instead that conservatism is weird. We develop this thought in the second part of the paper. In the final section we discuss some larger methodological issues about the project of ontology.
Fatherhood, gender and the making of professional identity in large law firms: bringing men into the frame
Authors: Collier Richard 
Published: July 2018

AbstractThis paper reframes debates about gender equality in the legal professions by interrogating the practices of men and interconnections between fatherhood, gender and parenting within the specific context of large corporate law firms. Drawing on interviews with male lawyer-fathers, it argues that closer exploration of fatherhood reveals much about the gendered dynamics of identity formation as a legal professional in this sector. A set of ideas about fatherhood, the paper suggests, shape how men's work can define a distinctive gender identity as a ‘family man’ and good lawyer. Political-economic and cultural shifts around fatherhood, however, are reconfiguring and adapting gender relations in law in a number of contradictory ways with implications for understanding the place of men in relation to gender-equality agendas. Ideas about fatherhood, family, work and career, I argue, are mobilised and enmeshed within the reproduction of distinctive law-firm cultures and gendered ideas of organisational commitment. What, in short, might it mean to bebotha ‘good father’ and a ‘good lawyer’?
Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration
Authors: Rajala Ammaji , Wang Yuhong , Soni Krutik , Rajala Raju V. S. 
Published: July 2018

AbstractThe tumor form of pyruvate kinase M2 has been suggested to promote cellular anabolism by redirecting the metabolism to cause accumulation of glycolytic intermediates and increasing flux through the pentose phosphate pathway, which is a metabolic pathway parallel to glycolysis. Both rod and cone photoreceptors express the tumor form of pyruvate kinase M2. Recent studies from our laboratory show that PKM2 is functionally important for rod photoreceptor structure, function, and viability. However, the functional role of PKM2 in cones is not known. In this study, we conditionally deleted PKM2 in cones (cone-cre PKM2-KO) and found that loss of PKM2 results in the upregulation of PKM1 and a significant loss of cone function and cone degeneration in an age-dependent manner. Gene expression studies on cone-cre PKM2-KO show decreased expression of genes regulating glycolysis, PPP shunt, and fatty acid biosynthesis. Consistent with these observations, cones lacking PKM2 have significantly shorter cone outer segments than cones with PKM2. Our studies clearly suggest that PKM2 is essential for the anabolic process in cones to keep them alive for normal functioning and to support cone structure.
MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer
Authors: Wang Qiu-Yu , Zhou Ci-Xiang , Zhan Meng-Na , Tang Jun , Wang Chen-Long , Ma Cheng-Ning , He Ming , Chen Guo-Qiang , He Jian-Rong , Zhao Qian 
Published: July 2018

AbstractThe miR-133b, a commonly recognized muscle-specific miRNA, was reported to be deregulated in many kinds of cancers. However, its potential roles in tumorigenesis remain greatly elusive. Herein, we demonstrate that miR-133b is significantly suppressed in human breast cancer specimens, which is reversely correlated to histological grade of the cancer. Ectopic expression of miR-133b suppresses clonogenic ability and metastasis-relevant traits in vitro, as well as carcinogenesis and pulmonary metastasis in vivo. Further studies have identified Sox9, c-MET, and WAVE2 as direct targets of miR-133b, in which Sox9 contributes to all miR-133b-endowed effects including cell proliferation, colony formation, as well as cell migration and invasion in vitro. Moreover, re-expression of Sox9 reverses miR-133b-mediated metastasis suppression in vivo. Taken together, these findings highlight an important role for miR-133b in the regulation of tumorigenesis and metastatic potential of breast cancer and suggest a potential application of miR-133b in cancer treatment.
Consequences of blunting the mevalonate pathway in cancer identified by a pluri-omics approach
Authors: Goulitquer Sophie , Croyal Mikaël , Lalande Julie , Royer Anne-Lise , Guitton Yann , Arzur Danielle , Durand Stéphanie , Le Jossic-Corcos Catherine , Bouchereau Alain , Potin Philippe , Akoka Serge , Antignac Jean-Philippe , Krempf Michel , Ferchaud-Roucher Véronique , Giraudeau Patrick , Corcos Laurent 
Published: July 2018

AbstractWe have previously shown that the combination of statins and taxanes was a powerful trigger of HGT-1 human gastric cancer cells’ apoptosis1. Importantly, several genes involved in the “Central carbon metabolism pathway in cancer”, as reported in the Kyoto Encyclopedia of Genes and Genomes, were either up- (ACLY, ERBB2, GCK, MYC, PGM, PKFB2, SLC1A5, SLC7A5, SLC16A3,) or down- (IDH, MDH1, OGDH, P53, PDK) regulated in response to the drug association. In the present study, we conducted non-targeted metabolomics and lipidomics analyses by complementary methods and cross-platform initiatives, namely mass spectrometry (GC-MS, LC-MS) and nuclear magnetic resonance (NMR), to analyze the changes resulting from these treatments. We identified several altered biochemical pathways involved in the anabolism and disposition of amino acids, sugars, and lipids. Using the Cytoscape environment with, as an input, the identified biochemical marker changes, we distinguished the functional links between pathways. Finally, looking at the overlap between metabolomics/lipidomics and transcriptome changes, we identified correlations between gene expression modifications and changes in metabolites/lipids. Among the metabolites commonly detected by all types of platforms, glutamine was the most induced (6–7-fold), pointing to an important metabolic adaptation of cancer cells. Taken together, our results demonstrated that combining robust biochemical and molecular approaches was efficient to identify both altered metabolic pathways and overlapping gene expression alterations in human gastric cancer cells engaging into apoptosis following blunting the cholesterol synthesis pathway.