bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personal and environmental change: A Hip Hop school counseling intervention
Authors: Levy Ian , Molina Citlali 
Published: November 2024

AbstractScholars criticize the profession of school counseling for the delivery of inadequate school counseling services to Black and Brown youth. Within schools, particularly those populated by Black and Brown youth, exist environmental barriers to youths’ wellness and development including a shortage of mental health professionals (i.e., high student‐to‐counselor ratios) or oppressive school structures (i.e., deficit‐oriented curriculum and discipline policies). This case study examined the use of a culturally responsive and theoretically sound Hip Hop and school counseling intervention that captures the experiences of students and adult participants. The results from this study help illustrate how the school studio, as a liberatory space, offered a hospitable environment that invited students’ authentic identity expression, fostered increased relationships with staff and their peers, and offered students a sense of confidence or personal empowerment.
Synthesis and application of poly(amidoamine) functional biomedical materials in the field of biomedicine over the past decade
Authors: Zhang Min , Guo Dandan , Zhou Xiaoqian , Zhou Ding , Zhu Yan , Huang Shaohua 
Published: November 2024

AbstractOver the past decade, significant advancements have been achieved in the field of biomedicine, particularly in the treatment of critical illness. However, there remain numerous challenges and barriers persist in drug delivery, medical imaging, diagnosis, and treatment. Poly(amidoamine) (PAMAM) dendrimers have emerged as promising candidates for the development of functional biomedical materials due to their advantageous properties, including ease of preparation, controllable size, abundant cavities, water solubility, modifiability, and biocompatibility. This article presents a comprehensive review of the synthesis, application, and potential toxicity of PAMAM functional biomedical materials, exploring the role, significance, and potential applications of PAMAM dendrimers in detail. The aim is to provide a valuable reference for the future development of biomedical materials and to inspire further discoveries in the field of polyamide functional materials.
Microscopic Characterization of Achillea santolina L. Flower Through Light Microscopy and Scanning Electron Microscopy
Authors: Urooj Uzma , Mazhar Farah , Azhar Iqbal 
Published: November 2024

ABSTRACTThis study is a comprehensive account of microscopic assessment of flower of Achillea santolina L., a medicinally important species of the genus Achillea from Pakistan. The study was aimed to provide data for the quality control and standardization of A. santolina L. flower. The microscopic characterization has been carried out through light microscopy and scanning electron microscopy. Various characteristic histological features of phyllaries, ray floret, disc floret, anther wall, filament, stigma, style, and ovary were observed. The pollens were found as tricolporate, spheroidal while the surface ornamentation was echinate. Qualitative and quantitative palyno‐anatomical assessment was carried out through scanning electron microscopy. The exine thickness and the width of spines were calculated. The P/E ratio characterized the shape of pollen as oblate‐spheroidal and sub‐oblate in polar and equatorial views respectively. The elemental analysis of the flower through SEM–EDX showed the presence of various elements. Phytochemical screening of flower showed the presence of carbohydrates, flavonoids, fixed oils, glycosides, phenols, steroids, tannins, terpenoids, and coumarins. UV–vis spectra of the ethanol extract showed characteristics peaks in both ultraviolet and visible regions. This work will provide a standard reference for the correct identification of A. santolina L. an important aspect in the quality control. Additionally, the data produced by phytochemical, elemental and florescence analysis, and UV–visible spectroscopy will help in developing standards for this herb that will be useful for research and development and manufacturing of herbal products.
Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1
Authors: Ansa‐Addo Ephraim A. , Pathak Paras , McCrossan Maria V. , Volpato Rossi Izadora , Abdullahi Mahamed , Stratton Dan , Lange Sigrun , Ramirez Marcel I. , Inal Jameel M. 
Published: November 2024

AbstractDuring cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP3‐mediated Ca2+ exit from the ER and further Ca2+ entry from plasma membrane channels was blocked, but whilst any store‐independent Ca2+ entry (SICE) could continue unabated. That lEV release was equally inhibited if all entry from external sources was blocked by chelation of external Ca2+ points to the major contributor to Mtr‐triggered host cell lEV release being IP3/store‐mediated Ca2+ release, SICE playing a minor role. Host cell lEVs were released through Mtr interaction with host cell lipid raft domains, integrins, and mechanosensitive ion channels, whereupon [Ca2+]cyt increased (50 to 750 nM) within 15 s. lEV release and cell entry of T. cruzi, which increased up to 30 and 60 mpi, respectively, as well as raised actin depolymerization at 60 mpi, were all reduced by TRPC inhibitor, GsMTx‐4. Vesicle release and infection was also reduced with RGD peptide, methyl‐β‐cyclodextrin, knockdown of calpain and with the calpain inhibitor, calpeptin. Restoration of lEV levels, whether with lEVs from infected or uninfected epithelial cells, did not restore invasion, but supplementation with lEVs from infected monocytes, did. We provide evidence of THP‐1 monocyte‐derived lEV interaction with Mtr (lipid mixing by R18‐dequenching; flow cytometry showing transfer to Mtr of R18 from R18‐lEVs and of LAP(TGF‐β1). Active, mature TGF‐β1 (at 175 pg/×105 in THP‐1 lEVs) was detected in concentrated lEV‐/cell‐free supernatant by western blotting, only after THP‐1 lEVs had interacted with Mtr. The TGF‐β1 receptor (TβRI) inhibitor, SB‐431542, reduced the enhanced cellular invasion due to monocyte‐lEVs.
Evaluating Disparities in COVID‐19 Clinical Outcomes Among Patients With Cirrhosis in North America and Europe—An International Registry Study
Authors: Hayat Umar , Moon Andrew M. , Gangwani Manesh K. , Hasan Fariha , Marjot Thomas , Barritt A. Sidney , Mirza Wasique , Deivert Duane , Aziz Muhammad , Dahiya Dushyant Singh , Ali Hassam , Inamdar Sumant , Garcia‐Saenz‐de‐Sicilia Mauricio 
Published: November 2024

ABSTRACTBackgroundPatients with decompensated cirrhosis have a higher risk of hospitalization, ICU admission, and death from COVID‐19. The impact of demographics on these outcomes remains uncertain.MethodsThe SECURE‐Liver and COVID‐Hep databases were utilized to evaluate disparities in COVID‐19 outcomes. Patients were stratified by North American and European cohorts. Bivariate and multivariable logistic regression was performed.ResultsA total of 718 cirrhosis patients with COVID‐19 were evaluated. In the North American cohort, Black patients had more comorbidities (CI: 1.86 vs. 1.83, p < 0.01), higher rates of hospitalization (77% vs. 85%, p < 0.01), ICU admission (27% vs. 40%, p = 0.05), and death (18% vs. 28%, p = 0.07). Hispanic patients had the lowest adverse outcome rates. In the European cohort, White patients had more comorbidities (CI; 1.63 vs. 1.31, p = 0.02), but non‐White patients had higher hospitalization rates (82% vs. 67%, p = 0.01), ICU admissions (15% vs. 18%, p = 0.04), and lower mortality rates (28% vs. 34%, p = 0.01).ConclusionBlack patients in North America had higher hospitalization, ICU admission, and death rates. In the European subgroup, White patients had higher death rates than non‐White patients. These disparities became statistically insignificant after adjusting for confounders, suggesting that non‐liver‐related comorbidities might increase the risk of adverse outcomes.
Dynamics of West Nile Virus Lineage 2 Spread in the Balkans in the Context of Global Spatio‐Temporal Dispersal
Authors: Suka Marija , Cirkovic Valentina , Siljic Marina , Jankovic Marko , Loncar Ana , Rajkovic Milica , Stamenkovic Gorana , Vukicevic‐Radic Olivera , Stanojevic Maja 
Published: November 2024

ABSTRACTWest Nile Virus (WNV) is considered one of the most widely distributed arboviruses worldwide. In 2018, Serbia was among the European countries reporting the highest number of WNV cases. This study aimed to characterize WNV strains circulating in Serbia, and to estimate the pathways and dynamics of WNV‐2 spread in the Balkans and globally through the phylogenetic approach. Fifty newly generated NS5 Serbian sequences were found to belong to WNV lineage 2. Phylodynamic analyses of the Balkan clade indicated the potential for an increase in genetic diversity and structure of virus populations. Presented phylogeographic analyses implied four instances of long‐distance WNV‐2 migration from Africa to Europe, during the 1940s to 1950s, while further dissemination of WNV‐2 originated in Hungary in mid‐1970s and subsequently spread to Austria and Serbia. Extensive dispersion took place during the 1990s–2000s, as the virus spread from Austria to central and western Europe, and from Hungary to the Balkans. Continuous phylogeography analysis of the Balkans WNV‐2 clade implied the central role of Serbia for WNV dissemination across the Balkan peninsula. Furthermore, previously undocumented instance of intercontinental migration of WNV‐2 from Europe to Asia was implied. In‐depth phylogenetic investigation into the global distribution of WNV‐2 may provide valuable insights into the prediction and prevention of potential epidemics.
Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model
Authors: Zhang Zhu‐Qing , Liao Dan , Guo Zhi‐Peng , Song Shuang‐Shuang , Liu Xue‐Jun 
Published: November 2024

ABSTRACTThe interaction between major depressive disorder (MDD) and overweight/obesity has received considerable attention owing to its widespread occurrence and the intricate biopsychological implications involved. Despite extensive research, the neural mechanisms underlying these comorbid conditions, particularly in terms of functional network connectivity (FNC), are still not well understood. This study aimed to clarify these mechanisms by utilizing resting‐state functional magnetic resonance imaging (rs‐fMRI) to examine both static and dynamic FNC. We analyzed data from 57 patients with both MDD and overweight/obesity (MDD‐OW), 57 MDD patients of normal weight (MDD‐NW), and 44 healthy controls, using techniques such as independent component analysis, sliding window analysis, K‐means clustering, and graph theory. In contrast to static FNC, which showed no significant differences, dynamic FNC analysis identified four consistent states across all participants. Both MDD groups demonstrated reduced flexibility in functional coordination among these states and decreased nodal characteristics within the salience network. Notably, the MDD‐OW group displayed enhanced dynamic FNC between the default mode network (DMN) and the executive control network (ECN) during certain states, which was inversely associated with the severity of depressive symptoms. These results highlight the importance of altered dynamic connectivity patterns in individuals with MDD and concurrent overweight/obesity, especially between the DMN and ECN, suggesting their potential utility as biomarkers for depressive states. This research contributes to our understanding of how comorbid overweight/obesity affects brain network dynamics in depressive disorders and provides a basis for targeted therapeutic strategies.
Temporal and Spatial Relationships Between Climatic Indices and Precipitation Zones in Europe, Spain and Catalonia
Authors: Platikanov Stefan , Lopez Jordi F. , Martrat Belen , Martin‐Vide Javier , Tauler Roma 
Published: November 2024

ABSTRACTThis study focuses on identifying distinct precipitation zones across Europe, Spain and Catalonia, and second, examining how various large‐ and small‐scale climatic patterns affect the precipitation in these zones. Previous research has focused primarily on the relationships between individual climatic indices and precipitation in specific regions but has often overlooked the combined influence of multiple climate signals on precipitation variability. To address these issues, this study proposes the use of principal component analysis (PCA) as a multivariate analysis framework to investigate the complex relationships amongst multiannual precipitation patterns at different spatial scales, specifically in Europe, Spain and Catalonia. Distinct correlations amongst total annual precipitation occur in European countries, Spanish provinces and small Catalonian regions. Europe and Spain have five precipitation zones, whereas Catalonia has four. The calculated trends indicate a total precipitation reduction in the Iberian Peninsula, western Mediterranean and southwestern Europe, with a projected further decrease. Conversely, northern and central Europe anticipate normal to high precipitation tendencies. A second PCA application explores time and spatial correlations between precipitation zones and local/global climatic indices. The Southern Annular Mode, key Pacific teleconnections (PNA, TNA, WHWP, PACWARM and BEST) and confirmed Atlantic patterns (EA, NAO and AO) emerged as influential. The WeMO and MO indices showed the expected relevance at local spatial resolutions. Multivariate data analysis methods for two‐ or multidimensional datasets, which span multiple years and various spatial units (countries/provinces/regions), can extend the use of multivariate data analysis tools for correlation analysis over time in diverse geographical areas, including other continents, with varying spatial and temporal resolutions. The inclusion of monthly average precipitation data as an additional dimension in datasets analysed by multivariate statistical methods, such as PCA, will improve the knowledge of spatiotemporal climate variability.
Archaeometric Study of the Colorants in the Finds From the 4th Century BC Cist Tomb at Lakkoma, Chalcidice
Authors: Vivdenko Svetlana , Vasileiadou Athina , Tsimbidou‐Avlonitou Maria , Konstanta Alexandros , Avlonitou Lydia , Zacharias Nikolaos 
Published: November 2024

ABSTRACTThe analytical findings concerning the red pigments used on various decorative features originating from a Macedonian, as well as the purple dye from the deceased's attire, are presented. The cist tomb, discovered in 1987 at the area of Lakkoma Chalcidice (Macedonia, Greece), dated to the 4th century bc and featured a wooden funeral couch with intricate ornaments, such as clay “eyes,” colored plaster, and clay gorgoneions. Vermilion and red ochre served as the main pigments of these decorative features. The pigments were applied in various combinations to produce a range of red hues, from deep to bright red. Furthermore, the precious vermilion was also used in every element of the couch. The stucco on the decoration was gypsum, whereas the preparation layers over clay and stucco elements consisted of calcite and lead white, respectively. The cloth covering the deceased was dyed with the most expensive organic dye of antiquity, the Tyrian (shellfish) purple. In this research, the preliminary identification of the chromophoric minerals in the colors of the samples was carried out with the examination of their optical characteristics in thin sections using polarizing light microscope (PLM) and with portable XRF. Physicochemical techniques, Raman and HPLC, were also used to definitively identify the pigments. Portable Raman spectrometer was used for the in situ analysis of the inorganic colorants of the decorative materials, whereas laboratory Raman spectrometer served for the identification of inorganic and organic colorants of the grain samples and the dye. High‐pressure liquid chromatography with diode array detector (HPLC‐DAD) was applied for the identification of the coloring components of the purple organic dye from the deceased's clothes. The samples examined (0.5‐ to 1.5‐mm diameter) were collected during the initial cleaning of the surface.
A multivariate study on the effect of 3D printing parameters on the printability of gluten‐free composite dough
Authors: Pradhan Abhishek , Saha Debapam , Tripathy Punyadarshini Punam 
Published: November 2024

AbstractBACKGROUNDThe advancement of three‐dimensional (3D) food printing technology is significantly influencing the food processing industry. The present study utilized extrusion 3D printing to create a gluten‐free dough composed of little millet flour (LMF), amaranth seed flour (ASF) and curry leaf flour (CLF). The primary objective was to elucidate the effects of various extrusion‐based 3D printing conditions, including extruder nozzle diameter (ND), extrusion rate (ER), print speed (PS) and layer height (LH) on the printability parameters of the dough.RESULTSIn this study, three formulations of composite dough were prepared (i.e., S1, S2 and S3) by varying LMF, ASF and CLF compositions; among which S1 composite (LMF:ASF:CLF::30:60:10 w/w) was found to have comparable viscoelastic properties with the wheat dough. Central composite design (CCD) was selected with 30 experimental runs and 3D dough samples were printed using S1 composite by varying ND, ER, PS and LH. Principal component analysis of the printed samples accounted for 82.75% of variability and classified the samples into three confidence ellipses. From the results of the CCD model, four solution parameters in terms of ND:ER:PS:LH::mm: pulse μL−1:mm s−1:%, namely, P1 (1.8:115:8:70), P2 (1.6:115:7.8:65), P3 (2:100:7.8:55) and P4 (2:105:6.2:75), with high desirability value (> 0.85) were selected for sample 3D printing and post‐baking analysis. The P1 sample was found to have least print deformations, highest print fidelity (85.66%), and lowest hardness (55.95 N) and fracturability (39.66 N) values, and hence was selected as optimized product.CONCLUSIONThe present study provides parametric solutions for efficient 3D printing of gluten‐free composite dough, aligning with the increasing dietary preferences and demand of novel functional customized foods. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Length of Time to Clinical Improvement After Orthopedic Oncology Surgery in Patients With Metastatic Cancer: A Multi‐Institution Patient‐Reported Outcome Study
Authors: Groundland John , Tokson Jacqueline Hart , Hakim Anne , Cizik Amy , Blank Alan , Lerman Daniel , Jones Kevin , Lor Randall R. 
Published: November 2024

ABSTRACTBackgroundCurrently, there is a paucity of data that describes the length of time required to realize improvement in pain and function following surgery for patients with metastatic cancer to bone.MethodsOne hundred patients with impending or completed pathologic fractures due to metastatic cancer to bone were enrolled in this prospective cohort study. Outcomes were measured with a Computer Adaptive Test of Patient Reported Outcomes for Pain Interference and Physical Function domains, to determine the time required to achieve a Minimal Clinically Important Difference (MCID) in the tested domains.ResultsEighty‐one patients were included in the analysis. Thirty‐two patients (39.5%) survived and completed the follow‐up to 1 year, while 23 (28.4%) died before the end of the data collection. Fifty‐one patients (63.0%) achieved at least a 5‐point improvement in Physical Function and 59 (72.8%) achieved at least a 5‐point improvement in Pain Interference. The time to achieve the MCID was 6 weeks for the Physical Function and 4 weeks for the Pain Interference domain.ConclusionThe majority of patients with impending or completed pathologic fractures due to metastatic cancer see clinically important improvements in pain and function after surgery in an average of 4 and 6 weeks, respectively.
Turning Viewers Into Consumers and Tourists: Uncovering the Multifaceted Engagement and Purchase Intentions of eSports Viewers Through Telepresence and Immersion
Authors: Xu Ye , Zhang Haonan , Xia Fangyu , Qian Han 
Published: November 2024

ABSTRACTThis study argues that the eSports live streaming viewers have a triple identity. It aims to investigate how eSports live streaming can turn streamers into consumers and potential eSports tourists from the aspect of viewer psychology and behavioral intentions. Based on 776 valid online questionnaires from eSports live streaming viewers, we use Stimulus‐Organism‐Response (SOR) theory to identify how their watching experience is influenced and what their behavior towards gifting streamers and purchasing tickets for offline eSports is. Using SmartPLS 4.0 to analyze causal relationships among variables, the research affirms that four specific live streaming stimuli positively affect telepresence and immersion, leading to increased gifting and purchase intentions. This article thus elucidates the psychological and behavioral mechanisms of eSports live streaming viewers, shedding light on their transition process into consumers and potential eSports tourists. The results provide valuable insights for eSports live streaming operators and demonstrate their contribution to eSports tourism.
Recent advances and perspectives of multifunctional nanogels in biomedical applications
Authors: Han Bicheng , Dai Zideng , Chen Hangrong 
Published: November 2024

AbstractNanogels (NGs) are considered as a kind of nanoscale hydrogels (<200 nm) endowing with the functions of both nanomaterials and hydrogels. In the last 20 years, NGs have garnered significant attention due to their versatility and adaptability. Herein, a comprehensive overview of the latest advancements and current research status of NGs is provided, with a particular focus on the synthesis strategies involving physical and chemical cross‐linking methods, as well as the advantages of NGs in drug loading and responsive release. Based on the diverse design strategies of NGs, four key biomedical applications, including inflammation therapy, regenerative medicine, bioimaging and tumor therapy are further summarized and discussed. Moreover, the existed inherent challenges facing NGs are proposed, while highlighting their potential to revolutionize therapeutic and diagnostic approaches. Finally, we look forward to the further development and promising potentials of NGs in biomedical applications. This review aims to serve as a valuable reference for researchers, providing some insights into the evolving landscape of NGs and their potential in advanced biomedical applications.