bluuebunny/crossref_metadata_2025_split huggingface dataset:
Travailler ensemble sans être d’accord. La régulation disjointe comme modalité de fonctionnement durable des organisations
Authors: Mainhagu Sébastien 
Published: October 2018

Cet article a pour finalité de compléter la Théorie de la Régulation Sociale de J.D. Reynaud. Ce dernier a défini les régulations de contrôle, autonomes et conjointes. Nous proposons l’ajout de la catégorie « régulation disjointe », qui se caractérise par la coexistence durable de deux règles – l’une issue de la direction, l’autre des salariés – pour faire fonctionner une même activité. Cette recherche illustre empiriquement la mise en exergue de cette nouvelle famille de régulation par l’observation des règles de gestion des ressources humaines d’une clinique française.
Management of patients with atypical squamous cells of undetermined significance (ASCUS) on Papanicolaou smears
Authors: Terry Richard R. 
Published: October 2018

Abstract
Management of patients whose Papanicolaou smears show atypical squamous cells of undetermined significance (ASCUS) is a complex challenge for the family physician. It is critical that patients with the ASCUS smear be properly evaluated and triaged, as the ASCUS smear may be a manifestation of high-grade disease in 20% or more of cases. Several options for triage exist. Colposcopy is considered by many the option of choice. However, alternative options include cervicography, speculoscopy, and human papillomavirus subtyping. For proper management of the patient with the ASCUS smear, the clinician must consider the patient's Pap test history, risk factors for cervical cancer, and the cytopathologist's interpretation/recommendation.
The efficacy of Virkon-S for the control of saprolegniasis in common carp, Cyprinus carpio L
Authors: Rahman Haitham Saeed , Choi Tae-Jin 
Published: October 2018

Background
Saprolegnia parasitica is a fish pathogen that causes severe economic losses worldwide. Virkon-S is a well-known disinfectant known to exhibit antimicrobial activities against bacteria, viruses, and fungi. In this study, we tested the anti-fungal activity of Virkon-S against S. parasitica, the major causal agent of saprolegniasis.

Methods
The lowest concentration of Virkon-S that prevented germination or the visible growth of spores and the percent spore germination were determined using potato dextrose agar plates containing different concentrations of Virkon-S. The cytotoxic effect was evaluated using the Ez-Cytox Cell Viability Assay with epithelioma papulosum cyprini (EPC) cells grown in L-15 medium and acute toxicity tests were carried out with cultured fingerlings of common carp for 96 h. Artificial infection with S. parasitica was performed by placing the fish in tanks containing zoospores of S. parasitica after descaling and wounding at three positions. The diseased fish were kept in tanks containing 2, 4, and 10 ppm of Virkon-S for 10 days to observe the treatment effect.

Results
The in vitro assay results showed that Virkon-S could inhibit spore germination and the resulting mycelial growth at a concentration as low as 4 ppm. No cytotoxic effect on EPC cells was observed even at a concentration as high as 100 ppm. Additionally, no acute toxicity in the common carp was observed at 10 ppm following 96 h exposure. Ten days of treatment with 4 and 10 ppm Virkon-S resulted in complete reversal of artificially-induced saprolegniasis in the common carp.

Discussion
This data indicates that Virkon-S can be used for the control of saprolegniasis without harmful effects in fish. However, further research on the effect in humans and food supplies is necessary.
In search of an optimum sampling algorithm for prediction of soil properties from infrared spectra
Authors: Ng Wartini , Minasny Budiman , Malone Brendan , Filippi Patrick 
Published: October 2018

Background
The use of visible-near infrared (vis-NIR) spectroscopy for rapid soil characterisation has gained a lot of interest in recent times. Soil spectra absorbance from the visible-infrared range can be calibrated using regression models to predict a set of soil properties. The accuracy of these regression models relies heavily on the calibration set. The optimum sample size and the overall sample representativeness of the dataset could further improve the model performance. However, there is no guideline on which sampling method should be used under different size of datasets.

Methods
Here, we show different sampling algorithms performed differently under different data size and different regression models (Cubist regression tree and Partial Least Square Regression (PLSR)). We analysed the effect of three sampling algorithms: Kennard-Stone (KS), conditioned Latin Hypercube Sampling (cLHS) and k-means clustering (KM) against random sampling on the prediction of up to five different soil properties (sand, clay, carbon content, cation exchange capacity and pH) on three datasets. These datasets have different coverages: a European continental dataset (LUCAS, n = 5,639), a regional dataset from Australia (Geeves, n = 379), and a local dataset from New South Wales, Australia (Hillston, n = 384). Calibration sample sizes ranging from 50 to 3,000 were derived and tested for the continental dataset; and from 50 to 200 samples for the regional and local datasets.

Results
Overall, the PLSR gives a better prediction in comparison to the Cubist model for the prediction of various soil properties. It is also less prone to the choice of sampling algorithm. The KM algorithm is more representative in the larger dataset up to a certain calibration sample size. The KS algorithm appears to be more efficient (as compared to random sampling) in small datasets; however, the prediction performance varied a lot between soil properties. The cLHS sampling algorithm is the most robust sampling method for multiple soil properties regardless of the sample size.

Discussion
Our results suggested that the optimum calibration sample size relied on how much generalization the model had to create. The use of the sampling algorithm is beneficial for larger datasets than smaller datasets where only small improvements can be made. KM is suitable for large datasets, KS is efficient in small datasets but results can be variable, while cLHS is less affected by sample size.
Nursing care systematization: the nurses’ perception / Sistematização da Assistência de Enfermagem: percepção dos enfermeiros
Authors: Silva Tatiana Gaffuri da , Da Silva Gelson Aguiar , Moser Denise Consuelo , Rodrigues de Oliveira Maier Suellen , Barbosa Leonardo Costa 
Published: October 2018

Objetivo: Identificar como enfermeiros de Terapia Intensiva de um Hospital do Norte do Espírito Santo percebem a Sistematização da Assistência de Enfermagem/SAE como método de cuidado Método: Trata-se de um estudo qualitativo com participação de quatro enfermeiros. A coleta de dados foi realizada por meio de entrevista semi-estruturada, pesquisa documental e observação não participante. Emergiram três categorias analíticas: “Aspectos Conceituais da SAE: identificando modelos”. “A fragmentação do método: do conceito à prática aplicada” e “A SAE na formação do enfermeiro: teoria x prática”. Resultados: Evidenciou fragilidades em relação à percepção dos enfermeiros sobre a SAE e o PE e sua exeqüibilidade. Conclusão: Rever o papel do enfermeiro, com vistas a retomada de suas responsabilidades com a saúde, pacientes e familiares restaurando seu compromisso com o cuidado efetivo e de qualidade. Descritores: UTI, Enfermagem, sistematização da assistência de enfermagem.
Influence of high serum alpha fetoprotein on patients with gastric cancer
Authors: Chen Ming‐Yao , Fang Wen‐Liang , Huang Kuo‐Hung , Lai Yu‐Hsin , Lin Hwai‐Jeng 
Published: October 2018

SummaryBackgroundsPatients with alphafetoprotein (AFP)‐producing gastric cancer (AFPGC) have a high incidence of liver metastasis and poor prognosis. However, the clinical manifestation of AFPGC remains controversial.MethodsWe enrolled patients who, before surgery, had gastric cancer with serum AFP levels of > 100 ng/mL (n = 30) and of ≦ 20 ng/mL (n = 1236). Clinical manifestations were compared between these two groups.ResultsCompared with in the AFP > 100 group, early gastric cancer was more frequent (30.1% vs. 0%) and advanced gastric cancer was less frequent (69.9% vs. 100%) in the AFP ≦ 20 ng/mL group (p < 0.001). Moreover, the incidence of liver and lymph node metastases was lower in the AFP ≦ 20 ng/mL group than in the AFP > 100 ng/mL group (4.4% vs. 43.3%, p < 0.001 and 60.7% vs. 93.3%, p < 0.001, respectively). More patients had stage IV AFPGC in the AFP > 100 ng/mL group than in the ≦ 20 ng/mL group (66.7% vs 27.1%, p < 0.001). Furthermore, fewer patients underwent curative surgery in the AFP > 100 ng/mL group (6.7% vs 37.9%, p < 0.001). More patients in the AFP > 100 ng/mL group died because of gastric cancer (66.7% vs 27.1%, p < 0.0001).ConclusionsPatients with very high serum AFP levels have a high incidence of liver and lymph node metastases and extremely poor prognosis.Copyright © 2017, The Gastroenterological Society of Taiwan, The Digestive Endoscopy Society of Taiwan and Taiwan Association for the Study of the Liver.
Endemic hepatitis B and C virus areas are associated with lower prevalence of hyperlipidemia: Ecological and cross‐sectional studies
Authors: Chen Chao‐Tung , Huang Wei‐Cheng , Wang Jing‐Houng , Lee Chuan‐Mo , Hung Chao‐Hung , Tsai Lin‐San , Chen Shu‐Chuan , Lin Sheng‐Che , Lu Sheng‐Nan , Kee Kwong‐Ming 
Published: October 2018

SummaryBackgroundsPatients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection have been documented to have lower levels of cholesterol and triglyceride. This study attempts to validate this correlation from ecological and cross‐sectional research in community.MethodsA total of 56,336 subjects in 533 villages of Tainan County underwent health screening in 2004. The antibody to HCV (anti‐HCV), Hepatitis B surface antigen (HBsAg), total cholesterol and triglyceride levels were checked. We used village as a unit to analyze the correlations between prevalence of HBsAg or anti‐HCV and hypercholesterolemia or hypertriglyceridemia. Statistical analyses were simple linear regression and Student t test.ResultsMean serum cholesterol and triglyceride levels were both significantly lower in subjects with HBV and HCV infection (all p < 0.001). Village‐specific prevalence rates of hypercholesterolemia (r = – 0.15) and hypertriglyceridemia (r = – 0.21) were negative correlated with prevalence of HBsAg significantly (all p < 0.001). Village‐specific prevalence rates of hypercholesterolemia (r = ‐ 0.323) and hypertriglyceridemia (r = ‐ 0.258) were also negative correlated with prevalence of anti‐HCV significantly (all p < 0.001).ConclusionsIn this community‐based study, endemic villages of HBV or HCV infection were associated with a lower prevalence of hypercholesterolemia and hypertriglyceridemia.Copyright © 2017, The Gastroenterological Society of Taiwan, The Digestive Endoscopy Society of Taiwan and Taiwan Association for the Study of the Liver.
Comparison between tenofovir disoproxil fumarate and entecavir treatment in real‐world clinical practice
Authors: Wang Ssu‐Han , Lan Keng‐Hsin , Liang Cheng‐Chao , Cheng Yuan‐Lung , Kao Wei‐Yu , Lin Han‐Chieh 
Published: October 2018

SummaryBackground and aimsEntecavir (ETV) and tenofovir disoproxil fumarate (TDF) are effective as two first‐line anti‐viral therapies for chronic hepatitis B (CHB); however, data are limited on directly comparing the safety and effectiveness of these two antivirals. Hence, we compared the efficacy and safety of TDF and ETV on treatment‐naïve patients with CHB.MethodsWe performed a hospital‐based, retrospective cohort study of 257 treatment‐naïve patients with CHB receiving TDF (n = 79) or ETV (n = 178). Virological and biochemical response as well as nephrotoxicity were assessed between TDF and ETV treatment groups.ResultsAt month 12, TDF group had faster on HBV DNA complete suppression than ETV group (p = 0.001). Multivariate analysis indicated that treatment with TDF was a significant predictor of HBV DNA suppression (HR = 1.33; 95% CI = 1.01 – 1.76; p = 0.045). In addition, HBeAg positivity (HR = 0.70; 95% CI = 0.52 – 0.96; p = 0.025) and higher baseline HBV DNA level (HR = 0.84; 95% CI = 0.76 – 0.92; p < 0.001) were significant negative predictors for viral suppression. The ALT normalization rate between these two treatment groups were similar (p = 0.114). TDF group had more populations in ≧ 20% decrease of eGFR MDRD at month 24 than ETV group (31.5% vs. 17.2%, p = 0.044), but only the baseline eGFR was the independent factor by multivariate analysis (OR = 1.05; 95% CI = 1.03 – 1.07; p < 0.001).ConclusionsTDF was significantly more effective in achieving complete viral suppression beyond month 12, and there was no significance in nephrotoxicity than ETV group.Copyright © 2017, The Gastroenterological Society of Taiwan, The Digestive Endoscopy Society of Taiwan and Taiwan Association for the Study of the Liver.
Detection of rectal neuroendocrine tumor during screening colonoscopy and its difference from colonic adenocarcinoma
Authors: Lin Cheng‐Kuan , Chung Chen‐Shuan , Chiang Tsung‐Hsien , Tu Chia‐Hung , Liang Cheng‐Chao 
Published: October 2018

SummaryBackgroundsThe incidence of rectal neuroendocrine tumors (NETs) diagnosed during screening colonoscopy is rising. The features and outcomes of these patients and their difference from colonic adenocarcinoma are unknown.MethodsData on subjects who underwent screening colonoscopy as part of a health checkup during a five‐year period were retrospectively analyzed. The prevalence and outcomes of the patients with rectal NETs were evaluated. The features of the patients with histopathologically proven NET and colonic adenocarcinoma were compared.ResultsA total of 8,278 subjects were enrolled. Rectal NETs were detected and diagnosed by histopathologic analysis in 13 patients (0.16%). The mean tumor size was 0.4 ± 0.25 cm and 7.7% of the patients had chronic diarrhea. Colonic adenocarcinoma was diagnosed in 24 patients (0.29%). Patients with rectal NETs were significantly younger than those with colonic adenocarcinoma (mean age: 49.4 ± 14.2 years versus 59.5 ± 11.5 years, p = 0.033) and had fewer symptoms (92.3% versus 41.7%, p = 0.001). All of the rectal NETs were successfully resected endoscopically by snare polypectomy or ligation‐assisted endoscopic mucosal resection. Histopathological analysis revealed WHO 2010 grade I NETs in all patients. No recurrence was detected during a mean follow‐up of 33 ± 15.2 months.ConclusionsRectal NETs are not uncommon incidental findings of the colonic malignancies during screening colonoscopy. Those were younger and more asymptomatic as compared with colonic adenocarcinoma. Using endoscopic resection can successfully remove these small tumors without recurrence.Copyright © 2017, The Gastroenterological Society of Taiwan, The Digestive Endoscopy Society of Taiwan and Taiwan Association for the Study of the Liver.
An Unprecedented, Lewis Acid‐Mediated, Metal‐Free Iodoannulation Strategy to Aromatic Iodides
Authors: Banik Trisha , Betkekar Vipul V. , Kaliappan Krishna P. 
Published: October 2018

AbstractA direct transformation of ortho‐alkynylated aromatic vinyl ethers to 1‐iodonaphthalenes and other iodo‐heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.
Real‐world comparison of the new 34 mm self‐expandable transcatheter aortic prosthesis Evolut R to its 31 mm core valve predecessor
Authors: Kalogeras Konstantinos , Kabir Tito , Mittal Tarun , Mirsadraee Saeed , Skondras Evangelos , Rahman Haley Shelley , Zuhair Mohamed , Vavuranakis Manolis , Tousoulis Dimitrios , Dalby Miles , Panoulas Vasileios 
Published: October 2018

AbstractObjectivesThe aim of the present study was to compare the incidence of periprocedural complications and short‐term outcomes between the second‐generation recapturable 34 mm Evolut‐R and its first‐generation 31 mm predecessor.BackgroundAlthough already in extensive clinical use in real world patients, the periprocedural complications and clinical outcomes of the new 34 mm device have not been investigated yet.MethodsConsecutive patients who had undergone transcatheter aortic valve implantation in two centers with either a 31 mm CoreValve or a 34 mm Evolut‐R device were retrospectively studied. Periprocedural complications of malpositioning, valve‐in‐valve implantation, conversion to full sternotomy or percutaneous coronary intervention and vascular complications were compared between the two groups. Short‐term outcomes at discharge were compared using Valve Academic Research Consortium (VARC‐2) criteria.ResultsThe study group included 106 patients (35 Evolut‐R 34 mm; 71 CoreValve 31 mm). Significantly lower rates of valve‐in‐valve implantation were demonstrated for the 34 mm group compared to the first‐generation device (0% vs. 11.9%, respectively, P = 0.036). All other periprocedural complications were similar between groups.At discharge, the rates of new pacemaker implantation (5.7% vs. 26.8%, P = 0.037) and bleeding complications (2.9% vs. 19.6%, P = 0.025) were statistically significantly lower among the 34 mm group. With regards to VARC‐2 defined combined endpoints, rates of early safety were significantly improved among the 34 mm group compared to 31 mm group (0% vs. 27.9%, respectively, P = 0.004).ConclusionsThe recently introduced 34 mm Evolut‐R seems to demonstrate an improved safety profile, as evidenced by the reduced bleeding rates, lower rates of valve‐in‐valve implantation and lower PPM rates compared to its 31 mm predecessor.
Long‐term outcome of brachytherapy treatment for coronary in‐stent restenosis: Ten‐year follow‐up
Authors: Nakahama Hiroko , Jankowski Michelle , Dixon Simon R. , Abbas Amr E. 
Published: October 2018

AbstractObjectivesThe objective of this study was to determine the long‐term major adverse cardiac events (MACE) in patients treated with intracoronary brachytherapy (ICBT) for coronary in‐stent restenosis (ISR).BackgroundICBT was commonly used to treat coronary ISR prior to the availability of drug‐eluting stents (DES). The long‐term outcomes of ICBT for ISR remain unknown.MethodsSix hundred and eighty consecutive patients who underwent ICBT treated for ISR between September 1998 and April 2005 were included in the study. Clinical and angiographic data were collected and the long‐term MACE were measured for all‐cause death, myocardial infarction (MI), and target vessel revascularization (TVR) at 10‐year follow‐up.ResultsPatients were 63 ± 11 years old (66% male). The majority of patients were treated with a bare metal stent 670/680 (99%) prior to ICBT. Significant baseline clinical findings include high incidence of smokers 479/680 (70%), hyperlipidemia 638/680 (94%), and multivessel disease 526/680 (77%). The majority of target lesions were diffuse 407/680 (60%), and either in the left anterior descending 258/680 (38%) or right coronary artery 215/680 (32%). At 10‐year follow‐up, the rate of death was 25%, MI was 22.4%, and TVR was 48%.ConclusionMACE at 10‐year follow‐up following ICBT for ISR indicates steady rate of death and MI and declining rate of TVR after 5 years.
Is a covered stent justifiable in the treatment of coronary artery perforation? An observational analysis of long‐term results of two different covered stent types
Authors: Rosseel Liesbeth , Scott Benjamin , Prihadi Edgard , Azzano Alessia , Degrauwe Sophie , Verheye Stefan , Convens Carl , Vermeersch Paul 
Published: October 2018

AbstractObjectivesIn this retrospective observational study, we investigate outcome of patients treated with or without covered stent (CS) implantation in the management of coronary artery perforation (CAP) during coronary intervention.BackgroundCSs have shown to be effective devices to achieve acute hemostasis in large CAP. However, doubts have been raised regarding their long‐term outcome.MethodsData of 19 061 PCI procedures during a 10‐year period were reviewed. Fifty‐five cases of large CAP were withheld (Ellis type 2, 3 or cavity spilling). All medical and procedural records of these cases were retrospectively reviewed.ResultsTwenty‐four (43.6%) patients were treated with CS implantation (15 polytetrafluoroethylene and 9 pericardium CSs). Twenty‐six (47.3%) patients were managed without CS implantation, of whom five had unsuccessful delivery of a CS (stent delivery failure 17.2%). Although significantly more Ellis type‐3 perforations were present in the CS group compared to the Non‐CS group (75.0% vs 45.2%; P = 0.03), in‐hospital mortality was not significantly different (8.3% vs 6.4%; [P = 0.79]). We observed a high rate of CS restenosis (29.2%) but a lower rate of CS thrombosis (4.2%). Despite these observations, 5‐year MACE and all‐cause mortality were not significantly different between CS and Non‐CS group (respectively, 58.8% vs 50.0% (P = 0.26) and 26.7% vs 13.3% (P = 0.36)).ConclusionAlthough deliverability of CSs was not flawless and a high rate of CS restenosis appeared, short‐ and long‐term outcome were comparable between patients treated with or without CS. Therefore, CSs are justifiable in the treatment of CAP.
Comparison of coronary revascularization appropriateness for non‐acute coronary syndrome cases under the 2017 update vs the 2012 appropriate use criteria
Authors: Case Brian C. , Geiser Katherine M. , Torguson Rebecca , Pichard Augusto D. , Satler Lowell F. , Waksman Ron , Ben‐Dor Itsik 
Published: October 2018

AbstractObjectivesTo compare coronary revascularization appropriateness for non‐acute coronary syndrome cases under the 2017 update vs the 2012 appropriate use criteria (AUC).BackgroundIn 2017, the 2012 AUC for coronary revascularization were updated. We examined how applying these new 2017 updates to our previous inappropriate cases would change their appropriateness.MethodsWe identified 50 cases of patients who underwent coronary revascularization for stable ischemic heart disease who were deemed inappropriate under the 2012 AUC. Two separate physicians reviewed the cases and applied a new AUC based on the 2017 AUC. Next, if there was a change, the reason was identified.ResultsAverage age was 64, majority being male (29; 58%). Forty‐two (84%) were asymptomatic upon presentation. Most cases (27, 54%) dealt with percutaneous coronary intervention (PCI) of the right coronary artery. After applying the 2017 AUC, 34 of the 50 inappropriate failures (68%) would be changed from “inappropriate” to “may be appropriate care.” Of the 34 cases, 25 (73.5%) were changed due to the new AUC no longer expecting the patient to be on ≥2 anti‐angina medications prior to PCI. Of the 34 cases, eight (23.5%) were changed due to the new AUC expanding the use of non‐invasive modalities.ConclusionsApplying the 2017 AUC led to a statistically higher number of cases being deemed “may be appropriate.” The most common cause for the change included the change in requirement for anti‐angina regimen and the expanded role of non‐invasive modalities.