bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Epitaxial Interfaces for Topological Insulator — Superconductor Hybrid Devices with Al Electrodes
Authors: Jalil Abdur Rehman , Schmitt Tobias W. , Rüßmann Philipp , Wei Xian‐Kui , Frohn Benedikt , Schleenvoigt Michael , Wittl Wilhelm , Hou Xiao , Schmidt Anne , Underwood Kaycee , Bihlmayer Gustav , Luysberg Martina , Mayer Joachim , Blügel Stefan , Grützmacher Detlev , Schüffelgen Peter 
Published: November 2024

AbstractProximity‐induced superconductivity in hybrid devices of topological insulators and superconductors offers a promising platform for the pursuit of elusive topological superconductivity and its anticipated applications, such as fault‐tolerant quantum computing. To study and harness such hybrid devices, a key challenge is the realization of highly functional material interfaces with a suitable superconductor featuring 2‐periodic parity‐conserving transport to ensure a superconducting hard‐gap free of unpaired electrons, which is important for Majorana physics. A superconductor well‐known for this characteristic is Al, however, its direct integration into devices based on tetradymite topological insulators has so far been found to yield non‐transparent interfaces. By focusing on Bi2Te3‐Al heterostructures, this study identifies detrimental interdiffusion processes at the interface through atomically resolved structural and chemical analysis, and showcases their mitigation by leveraging different interlayers – namely Nb, Ti, Pd, and Pt – between Bi2Te3 and Al. Through structural transformation of the interlayer materials (X) into their respective tellurides (XTe2) atomically‐sharp epitaxial interfaces are engineered and further characterized in low‐temperature transport experiments on Al‐X‐Bi2Te3‐X‐Al Josephson junctions and in complementary density functional theory calculations. By demonstrating functional interfaces between Bi2Te3 and Al, this work provides key insights and paves the way for the next generation of sophisticated topological devices.
Development of a Load‐Bearing, Terrain‐Adaptive Hexapod Robot With Chebyshev‐Linkage Legs
Authors: Ju Zhongjin , Wu Rui , Guo Dameng , Xu Yundou 
Published: November 2024

ABSTRACTThis study introduces an exploratory design for a hexapod load‐carrying robot, aiming to address challenges commonly associated with quadruped robots, including limited load capacity and high control complexity. By leveraging a Chebyshev linkage‐based overconstrained leg‐foot architecture that combines high rigidity and low friction, along with a multi‐drive system for lateral movement, we propose a robot with improved adaptability to diverse terrains, such as snow, sand, puddles, ice, and deserts. This versatility suggests potential applications in areas such as factory inspection, field reconnaissance and transport, and desert exploration. Using static and dynamic analyses, we evaluated the leg structure's stress distribution and motion requirements, employing simulations in Workbench and Adams to cross‐validate our theoretical calculations. The development of a prototype and its subsequent testing under various environmental conditions aimed to demonstrate the design's practicality and the robot's operational capabilities in real‐world settings. Although the findings indicate progress toward enhancing load‐bearing capabilities and terrain adaptability with reduced control complexity, further research and development are necessary to fully realize the potential of such robotic systems in practical applications.
Microwave‐Assisted Fabrication of Copper Oxide/N‐Doped Carbon Nanocatalyst for Efficient Electrochemical CO2 Conversion to Liquid Fuels
Authors: Banerjee Anwesha , Jain Siddarth , Dastider Saptarshi Ghosh , Biswas Rathindranath , Das Srewashi , Mondal Krishnakanta , Vishal Vikram , Lahiri Goutam Kumar , Dutta Arnab 
Published: November 2024

AbstractElectrochemical CO2 reduction reaction (CO2RR), which is driven by electricity generated from renewable energy sources, is a promising technology for sustainably producing carbon‐based chemicals or fuels. Several CO2RR catalysts have been explored to date, among which copper‐based electrocatalysts are the most widely known for electrochemical CO2RR and are extensively studied for their ability to generate an array of products. Their low selectivity, however, hinders their possibility of being used for practical purposes. In this work, a microwave‐assisted one‐pot synthesized CuxO/N‐doped carbon demonstrates the electrochemical conversion of carbon dioxide into multiple C1 products (mainly formate and methanol), with a maximum Faradaic efficiency of 95% in 0.10 m KHCO3 aqueous solution at a moderately low applied potential of −0.55 V versus RHE (reversible hydrogen electrode). The in‐depth theoretical study reveals the key contribution of pyridinic N‐based N‐doped carbon sites and Cu2O clusters in CO2 adsorption and its subsequent conversion to formate and methanol via an energetically favorable formate pathway. The electrocatalyst continued to demonstrate CO2 reduction to valuable C1 products when a simulated flue gas stream containing 15% CO2 along with 500 ppm SOx and 200 ppm NOx is used as an inlet feed.
Development of Turbocharging‐Ability Hybrid Nanogenerators Comprising Bipolar PVDF‐HFP/MXene Electrospun Composites
Authors: Gajula Prasad , Yoon Jae Uk , Woo Insun , Bae Jin Woo 
Published: November 2024

AbstractCoupling piezo‐active and triboelectric materials has recently emerged as an effective technique for developing high‐performance hybrid nanogenerators (HNGs). This is the first paper to report the fabrication of piezo‐active poly(vinylidene fluoride‐hexafluoropropylene)(PVDF‐HFP)/MXene‐based hybrid composite fibers through conventional electrospinning. Here, the effect of MXene content (1–5%) on the surface potential and electrical performance of the as‐synthesized composites is investigated and optimized. PVDF‐HFP/3% MXene (PHM3)/Nylon 12+A‐rGo (NY2)‐HNG, which contains the best‐performing composite (PMH3; containing 3% of MXene), exhibits turbocharging properties (charging a 10 µF capacitor with 16 V within 100 s) and can continuously operate low‐power electronics. Interestingly, PHM3 (with a negative surface potential) is transformed into PPHM3 (with a positive surface potential of +2190 V) via corona poling. This study proposes a new class of HNGs containing frictional layers comprising bipolar PVDF‐HFP/3% MXene composites (PHM3/PPHM3‐HNG) with an excellent output performance of 297 V and 5.1 µA that exhibit broad application prospects in energy harvesting.
Hypericum Perforatum Callus Extract‐Loaded Composite Hydrogel with Diverse Bioactivities for Enhanced Wound Healing and Fibrosis Prevention
Authors: Zivari‐Ghader Tayebeh , Shokouhi Behrooz , Kosari‐Nasab Morteza , Davaran Soodabeh , Hamishehkar Hamed , Farahpour Mohammad Reza , Rashidi Mohammad‐Reza , Mehrali Mehdi 
Published: November 2024

AbstractPlant Callus are a valuable source of pluripotent stem cells and bioactive phytochemicals. Meanwhile, the Hypericum perforatum callus extract (HPCE) is particularly rich in compounds such as hyperforin, hypericin, quercetin, and other phenolic and flavonoid derivatives. These phytochemicals exhibit strong antibacterial, antioxidant, anti‐inflammatory, and anti‐fibrotic properties, making them promising for wound healing. One of the most critical challenges following wound healing is the formation of fibrosis, which can compromise the complex structural integrity of skin. To address this issue, a poly(vinyl alcohol)/chitosan/alginate (PCA) wound dressing loaded with HPCE is developed. This hydrogel dressing features a porous structure with suitable mechanical properties and a high swelling capacity, potentially enhancing its effectiveness in promoting tissue regeneration and wound healing. In vitro studies have confirmed its biocompatibility, cell proliferation, and cell adhesion properties. Additionally, the dressing has demonstrated the ability to inhibit the proliferation of certain antibiotic‐resistant bacteria. The in vivo studies revealed the anti‐inflammatory properties, promotion of angiogenesis, facilitation of re‐epithelialization, and stimulation of collagen deposition of the dressing under investigation. Moreover, the immunohistochemistry analysis of the two key markers, p16 and p53, has shown that the application of the dressing helps prevent fibrosis after wound healing.
Construction of Ternary Zn0.5Cu0.5Co2O4 Spinel Structure on Nickel Foam: A Comprehensive Theoretical and Experimental Study from Single to Ternary Metal Oxides for High‐Energy‐Density Asymmetric Supercapacitor Application
Authors: Yesuraj Johnbosco , Senthamaraikannan Thillai Govindaraja , Lim Dong‐Hee , Kim Kibum 
Published: November 2024

AbstractDeveloping nanostructured multi‐transition metal‐based spinel architectures represents a strategic approach for boosting the energy density of supercapacitors while preserving high power density. Here, the influence of incorporating Zn and Cu into Co3O4 spinel systems on supercapacitor performance is investigated by synthesizing single (ZnO, CuO, Co3O4), binary (ZnCo2O4, CuCo2O4), and ternary (Zn0.5Cu0.5Co2O4) oxides on nickel foam substrates. Theoretical and experimental analyses highlight that the flower‐like structures of Zn0.5Cu0.5Co2O4, comprising nanowires and nanoribbons, effectively reduced transport barriers and enhanced ion adsorption, thereby improving electron/ion reaction kinetics. Oxygen vacancies induced defect states in Zn0.5Cu0.5Co2O4, shifting the d‐ and p‐band center values closer to the Fermi level and enhancing electrochemical performance. The Zn0.5Cu0.5Co2O4 exhibits a specific capacity of 271 mA h g−1 (1776 F g−1) at 1 A g−1 with 97% capacity retention after 5 000 charge/discharge cycles. In a Zn0.5Cu0.5Co2O4//activated carbon configuration, the device demonstrates superior energy and power densities of 122.2 Wh kg−1 and 800 W kg−1, respectively, maintaining 91% capacitance after 10 000 cycles at 30 A g−1 with high coulombic efficiency. This study presents an effective strategy to enhance ion/charge transfer and adsorption in multi‐transition metal spinel architectures, advancing the development of supercapacitor electrodes.
The genus Derris Lour., a potential source of valuable biologically active ingredients
Authors: Nha Trang Bui Thi , Mai Nguyen Thi , Anh Bui Thi Mai , Dung Duong Thi , Tai Bui Huu , Kiem Phan Van 
Published: November 2024

AbstractThis article summarizes the recent reports on the chemical components and biological activities of the genus Derris Lour. There are about 240 compounds isolated from this genus, including 31 rotenoids, 146 flavones and their derivatives (flavans, isoflavones, chalcones), 7 triterpenoids, 23 pterocarpans, 10 coumarins, and 34 other compounds. Many compounds have unique structures and exhibit potential biological effects including insecticides, antioxidant, antimicrobial, antifungal, antihyperglycemic, and cytotoxic activities. This review aims to systematically provide research results on the chemical composition and biological activities of Derris species.
A Survey Study on Management Practices Associated With Voluntary Waiting Period and Its Effects on Reproductive Performance of dairy cows in Iranian Dairy Farms
Authors: Mirzaie Behnaz , Sadeghi‐Sefidmazgi Ali , Zhandi Mahdi 
Published: November 2024

ABSTRACTBackgroundVoluntary waiting period (VWP), housing systems and the presence of a veterinarian are effective factors on reproductive performance of a dairy farm.ObjectivesThis study aimed to investigate the management practices associated with VWP and its effects on reproductive performance.MethodsA total of 136,943 records of 21,756 cows that calved between 1990 and 2013 were used. A questionnaire was also conducted with the farms involved to determine if they adjust the timing of insemination based on the body condition score (BCS) of the cows, postpartum health situation (PPHS) or environmental factors such as heat stress and season. The impact of changing the VWP selectively, the presence of a veterinarian and the type of barn on reproductive outcomes like days open (DO), number of services per conception (NSPC) and days to first service (DFS) was examined using a linear mixed model. This model considered animals and herds as random factors and management practices as fixed factors in the analysis.ResultsAmong herds that reported altering the VWP based on heat stress, DFS significantly increased (61.68 ± 0.68 vs. 58.4 ± 0.83) while DO (119.70 ± 1.86 vs. 126.9 ± 2.29) and NSPC (1.98 ± 0.04 vs. 2.48 ± 0.05) reduced compared to herds that did not alter the VWP. Our results showed that farms with a full‐time veterinarian had a better reproductive performance than those with part‐time care (p < 0.05). Housing system was significantly associated with fertility traits, so that cows in free‐stall barns were more fertile than those kept in open‐shed barns.ConclusionsThe obtained results from this study indicated that management decisions to selectively altering the VWP led to difference in DFS and improved reproductive performance.
Positionspapier der DGKL und der DIVI zu den Anforderungen an die Laboratoriumsmedizin in der Intensiv- und Notfallmedizin
Authors: Waydhas Christian , Hermes Carsten , Kumpf Oliver , Mutlak Haitham , Spannagl Michael , Walcher Felix , Luppa Peter B. ,   DIVI,   DGKL
Published: November 2024

Zusammenfassung

Hintergrund und Ziele
Die zeitgerechte Bestimmung und Bewertung von Laborparametern bei Patienten mit akuten lebens- oder organbedrohlichen Erkrankungen und Erkrankungszuständen in der Notaufnahme oder auf Intensivstationen kann für die Diagnosestellung, den Therapiebeginn und das Ergebnis essenziell sein. Ziel des Positionspapiers ist es, die zeitlichen Anforderungen an die Bereitstellung von labormedizinischen Ergebnissen in der Notfall- und Intensivmedizin zu definieren. Aus der Dringlichkeit lassen sich Anforderungen an Point-of-Care-Testung (POCT) und (zentrales) Labor ableiten.

Methodik
Expertengruppen aus der Deutschen Gesellschaft für Klinische Chemie und Laboratoriumsmedizin (DGKL) und der Deutschen Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI) entwickelten unter Nutzung von nationalen und internationalen Leitlinien, Reviewartikeln und Originalarbeiten eine Einteilung zur Dringlichkeit von Laborbestimmungen sowie Empfehlungen zu den erforderlichen Rahmenbedingungen und zur Qualitätssicherung.

Ergebnisse
Es werden 3 Stufen der Dringlichkeit für die Bestimmung der gängigsten Laborparameter anhand der Turnaround Time definiert: Notfall 1, mit einer Turnaround Time von maximal 15 min; Notfall 2, mit einer Turnaround Time von maximal 60 min; dringlicher Fall, mit einer Turnaround Time innerhalb von 4 h. Zusätzlich wird eine Empfehlung zur Bereitstellung der Ergebnisse zur Hauptvisite auf der Intensivstation und der Notaufnahme gegeben.

Schlussfolgerungen
Die Empfehlungen erlauben, die organisatorischen und apparativen Regelungen für jedes Krankenhaus anhand der medizinischen Anforderungen an die Dringlichkeit auszurichten.
Algebraic cycles on hyper-Kähler varieties of generalized Kummer type
Authors: Floccari Salvatore , Varesco Mauro 
Published: November 2024

Abstract
We prove the conjectures of Hodge and Tate for any four-dimensional hyper-Kähler variety of generalized Kummer type. For an arbitrary variety X of generalized Kummer type, we show that all Hodge classes in the subalgebra of the rational cohomology generated by

$$H^2(X,\mathbb {Q})$$

H
2

(
X
,
Q
)

are algebraic.
On the moment measure conjecture
Authors: Heinloth Jochen , Zhang Xucheng 
Published: November 2024

Abstract
The moment measure conjecture of Białynicki-Birula and Sommese gives a combinatorial characterization of all open substacks of a global quotient stack for a torus action on a normal projective variety that admit a proper good moduli space, in other words it characterizes the invariant open subvarieties that admit a proper quotient. In this article we prove the conjecture for actions on smooth varieties. This gives an instance of stability conditions defined by cohomological invariants that are not given by Chern classes of line bundles.
Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment
Authors: Aust Anne-Christine , Vidova Veronika , Coufalikova Katerina , Smetanova Sona , Kozeluhova Kristyna , Micenkova Lenka , Videnska Petra , Smatana Stanislav , Budinska Eva , Borek Ivo , Janku Petr , Klanova Jana , Spacil Zdenek , Thon Vojtech 
Published: November 2024

Abstract
In the first days of life, the newborns’ intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns’ microbiome development is degraded when mother is treated with ATB before or during delivery.

Key points
• Antibiotic treatment diminishes the positive effects of vaginal delivery.
• Antibiotic treatment affects metabolite and microbial composition in newborns.
• Bifidobacterium and Peptoclostridium could be the producer of indole-lactic acid.
Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity
Authors: Ohtani Tomoko , Kuroda Shinji , Kanaya Nobuhiko , Kakiuchi Yoshihiko , Kumon Kento , Hashimoto Masashi , Yagi Chiaki , Sugimoto Ryoma , Kikuchi Satoru , Kagawa Shunsuke , Tazawa Hiroshi , Urata Yasuo , Fujiwara Toshiyoshi 
Published: November 2024

Abstract
Dendritic cells (DCs) are crucial in cancer immunity, because they activate cytotoxic T cells by presenting tumor antigens. Recently, oncolytic virus therapy has been recognized as a systemic immune stimulator. We previously developed a telomerase-specific oncolytic adenovirus (OBP-301) and a p53-armed OBP-301 (OBP-702), demonstrating that these viruses strongly activate systemic antitumor immunity. However, their effects on DCs remained unclear. In the present study, the aim was to elucidate the mechanisms of DC activation by OBP-702, focusing particularly on tumor-derived exosomes. Exosomes (Exo53, Exo301, or Exo702) were isolated from conditioned media of human or murine pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and PAN02) after treatment with Ad-p53, OBP-301, or OBP-702. Exo702 derived from Panc-1 and MiaPaCa-2 cells significantly upregulated CD86, CD80, CD83 (markers of DC maturation), and IFN-γ in DCs in vitro. Similarly, Exo702 derived from PAN02 cells upregulated CD86 and IFN-γ in bone marrow-derived DCs in a bilateral PAN02 subcutaneous tumor model. This DC maturation was inhibited by GW4869, an inhibitor of exosome release, and anti-CD63, an antibody targeting the exosome marker. Intratumoral injection of OBP-702 into PAN02 subcutaneous tumors significantly increased the presence of mature DCs and CD8-positive T cells in draining lymph nodes, leading to long-lasting antitumor effects through the durable activation of systemic antitumor immunity. In conclusion, tumor-derived exosomes play a significant role in DC maturation following OBP-702 treatment and are critical for the systemic activation of antitumor immunity, leading to the abscopal effect.
Imaging of peritoneal metastases of ovarian and colorectal cancer: joint recommendations of ESGAR, ESUR, PSOGI, and EANM
Authors: Vandecaveye Vincent , Rousset Pascal , Nougaret Stephanie , Stepanyan Artem , Otero-Garcia Milagros , Nikolić Olivera , Hameed Maira , Goffin Karolien , de Hingh Ignace H. J. , Lahaye Max J. ,   for the European Society of Gastrointestinal and Abdominal Radiology (ESGAR),   European Society of Urogenital Radiology (ESUR),   Peritoneal Surface Oncology Group International (PSOGI), de Hingh Ignace H. J. ,   European Association of Nuclear Medicine (EANM)
Published: November 2024

Abstract
Objectives
Diagnostic imaging of peritoneal metastases in ovarian and colorectal cancer remains pivotal in selecting the most appropriate treatment and balancing clinical benefit with treatment-related morbidity and mortality. To address the challenges related to diagnostic imaging and detecting and reporting peritoneal metastatic spread, a joint guideline was created by the European Society of Gastrointestinal and Abdominal Radiology (ESGAR), European Society of Urogenital Radiology (ESUR), Peritoneal Surface Oncology Group International (PSOGI), and European Association of Nuclear Medicine (EANM).

Methods
A targeted literature search was performed and consensus recommendations were proposed using Delphi questionnaires and a five-point Likert scale.

Results
A total of three Delphi rounds were performed. Consensus was reached on the position of diagnostic imaging for assessment of operability, treatment response monitoring, and follow-up of peritoneal metastases, optimal imaging modality and their technical imaging requirements depending on the indication and how to optimise communication of imaging results by the report and multidisciplinary board discussion. The complete list of recommendations is provided.

Conclusion
These expert consensus statements aim to guide appropriate indications, acquisition, interpretation, and reporting of imaging for operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in ovarian and colorectal cancer patients.

Key Points
QuestionStaging peritoneal metastases (PM) helps to guide clinical decision-making for colorectal and ovarian cancer patients. How can we optimise the use of imaging techniques to assess PM?
FindingsImaging plays a crucial role in the detection, operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in colorectal and ovarian cancer patients.
Clinical relevanceThese expert consensus statements aim to guide appropriate indication, acquisition, interpretation, and reporting of imaging for operability assessment, treatment response monitoring, and follow-up of peritoneal metastases in ovarian and colorectal cancer patients.