bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxane Induced Cystoid Macular Edema: Case Report and Integrated Pathogenic Theory
Authors: Kanakis M. , Georgalas I. , Makatsoris T. , Pharmakakis N. 
Published: August 2018

Purpose:
To report a case of a 73-year-old man who presented with decreased visual acuity due to bilateral macular edema after paclitaxel administration for prostate cancer.

Methods:
The ophthalmic evaluation consisted of medical and ocular history, Best Corrected Visual Acuity, slit-lamp biomicroscopy and Spectral-domain optical coherence tomography / Fluorescein Angiography.

Results:
Optical Coherence Tomography and Fluorescein Angiography revealed silent cystoid macular
edema. After consulting with the oncologist, the cessation of paclitaxel therapy was decided. The
patient presented a gradual but steady resumption of the retinal edema, with complete restoration of
normal retinal morphology and function within two months. The pathogenesis of the silent Cystoid
Macular Edema (CME) is still unclear. Based on our case and a critical review of the previous
observations and published data, we propose that the underlying cause of Taxane induced CME is the
functional failure of Aquaporin mediated water transport at the level of retinal Intermediate and Deep
capillary plexuses, and at lesser extent at the level of the Retinal Pigment Epithelium.

Conclusion:
Taxane induced silent CME should be attributed to the action of Taxanes on the
microtubule guided aquaporin vesicles transport to the cell membrane. In our case of Taxane induced
silent CME, withdrawal of the taxane was enough for complete recovery, and no additional treatment
was needed.
The Role of Heat Shock Proteins in Cisplatin Resistance
Authors: Krawczyk Zdzisław , Gogler-Pigłowska Agnieszka , Sojka Damian R. , Scieglinska Dorota 
Published: August 2018

Background:
Cisplatin (CDDP), a small molecule platinum-based compound, is an effective anticancer
drug used against a wide range of human neoplasms. Long-term clinical use of CDDP is however limited
due to the development of drug resistance and the possible incidence of serious side effects including nephrotoxicity
and ototoxicity. The mechanisms underlying resistance of cells to CDDP are complex, and among them, the
cytoprotective involvement of proteins referred to as Heat Shock Proteins (HSP) seems potentially important.

Methods:
We searched various electronic databases including PubMed and selected the reports concerning the
contribution of HSPs to CDDP resistance of cancer cells and to minimize the CDDP-induced nephrotoxicity and
ototoxicity.

Results:
This critical review of data collected so far summarizes the results on the major HSPs: HSP27/HSPB1,
HSP70/HSPA1, HSP90/HSPC and GRP78/HSPA5, because only these have been the subject of the most intense
research in the matter discussed here. We also provide relevant information concerning some other HSPs,
namely HSPA9/mortalin, HSPA2, HSP110 and DNAJ. A possible role of HSPs in counteracting CDDP-induced
neprho- and ototoxicity is mentioned.

Conclusions:
This review shows that no universal relationship between the levels of expression of HSPs and
sensitivity of cancer cells to CDDP can be confirmed. Multiple observations indicate however that such correlation
can rather manifest as a molecular or cellular context-dependent phenomenon. Thus, HSPs can be viewed as
an important component of the multifactorial, complex response of cancer cells to CDDP. However, to
strengthen such a conviction, more extensive studies are needed.
A Multi-targeted Natural Flavonoid Myricetin Suppresses Lamellipodia and Focal Adhesions Formation and Impedes Glioblastoma Cell Invasiveness and Abnormal Motility
Authors: Zhao Hua-Fu , Wang Gang , Wu Chang-Peng , Zhou Xiu-Ming , Wang Jing , Chen Zhong-Ping , To Shing-Shun Tony , Li Wei-Ping 
Published: August 2018

Background:
Glioblastoma multiforme (GBM) is the most aggressive and malignant primary
brain tumor characterized by rapid growth and extensive infiltration to neighboring normal brain
parenchyma, which contribute to tumor recurrence and poor prognosis. Myricetin is a natural flavonoid
with potent anti-oxidant, anti-inflammatory and anti-cancer activities, which may serve as a potential
and harmless agent for GBM treatment.

Methods:
To investigate the anti-glioblastoma effects of myricetin, GBM cells were treated with
myricetin alone or in combination with temozolomide. Its effects on GBM cell motility and cytoskeletal
structures including lamellipodia, focal adhesions and membrane ruffles were also evaluated.

Results:
We showed that myricetin alone inhibited glioblastoma U-87 MG cell proliferation, migration
and invasion, whereas combination of myricetin and temozolomide did not exhibit any synergistic effect.
The inhibitory effect on GBM cell proliferation is independent of PTEN status. Moreover,
myricetin showed less cytotoxicity to normal astrocytes than GBM cells. Formation of lamellipodia,
focal adhesions, membrane ruffles and vasculogenic mimicry were blocked by myricetin, and phosphorylation
of ROCK2, paxillin and cortactin was suppressed. In addition, myricetin could inhibit
PI3K/Akt and JNK signaling, and bind to a series of kinases and scaffold proteins including PI3K
catalytic isoforms (p110α, p110β and p110δ), PDK1, JNK, c-Jun, ROCK2, paxillin, vinculin and VEcadherin.

Conclusions:
In conclusion, myricetin is a multi-targeted drug that has potent anti-migratory and antiinvasive
effects on GBM cells, and suppresses formation of lamellipodia and focal adhesions, suggesting
that it may serve as an alternative option for GBM treatment.
Clinical progression of burned children after Acinetobacter infections
Authors: Otuzoğlu Münevver , Şenaylı Atilla , Sarı Emre Nur , Özcan Fatma , Şenel Emrah 
Published: August 2018

Background:	One of the mortality causes for burned children is Acinetobacter infection. In this study, we aimed to investigate the possible causes of Acinetobacter infections in our burn centre. We also investigated the possibility reasons of the spread from other centres to our burn unit. Material and MethodsDuring the evaluation of clinical course of burned patients, presence of Acinetobacter baumannii infections were also investigated in wound and blood cultures. Archives from August 2011 to May 2014 were evaluated for ages, percentages, hospitalization days, reasons of burns, transferring centres, infection existence time, culture types, antibiotics, exitus and discharges. Results were evaluated statistically (p&lt;0.05).Results	Reasons of burns and time of acinetobacter existence were significantly different in the clinical course (p=0.024). Also, the existence of acinetobacter infections was correlated with increase in burn percentage (p=0.011). Finally, culture findings about Acinetobacter infections affect remissions (p=0.047).ConclusionReasons of burns, hospitalization days and culture findings are very important for burned children infected with acinetobacter. Clinicians must be cautious in these aforementioned situations. Death may be seen if not precautions are taken. Literature is lacking on risk parameters, therefore our study will have an additive affect to literature in this subject.
Tiempo presente, tiempo pasado. Las raíces históricas y filosóficas del periodismo cívico
Authors: Dillon Mike 
Published: August 2018

<p>En este trabajo el autor realiza un recorrido sobre los objetivos y los acontecimientos que dan significado al desarrollo de un periodismo que busca incluir la participación y el compromiso de la comunidad. El periodismo cívico se define no como “vino viejo en botella nueva”, sino como una manifestación de su tiempo, de un devenir histórico que le demanda al periodismo la recuperación de sus ideales.</p><p> </p>
Conflictos territoriales y perspectivas de desarrollo de la energía eólica en el istmo de Tehuantepec
Authors: Avilés Hernández Olinca Valeria 
Published: August 2018

<p>El presente artículo versa sobre los conflictos territoriales que surgieron a partir del desarrollo de energía eólica en el istmo de Tehuantepec oaxaqueño. Tal problemática se inició en 1994, con la instalación de la primera central eólica en Latinoamérica, denominada “La Venta I”, y en la actualidad continúa profundizándose debido a la llegada de más proyectos del mismo tipo. El trabajo se elaboró desde la perspectiva de la sociología política, orientación teórica con la que se analiza el proceso de transformación de la estructura territorial agraria mexicana en el istmo de Tehuantepec, el cual devino un plan de desarrollo energético, que provocó una confrontación entre dos grupos de interés sobre un mismo territorio: propietarios rurales y empresas eólicas. ¿Quiénes son los protagonistas de esta transformación territorial?, ¿qué cambia y qué permanece en este proceso histórico? Para el análisis de este complejo proceso de “modernización” y cambio de política energética, se compuso este texto, organizado en tres apartados que intentan englobar los aspectos más relevantes del problema.</p>
Continuously Monitoring Bank Risk, Reputation, and Opportunity
Authors: O'Leary Daniel E. , Spangler Scott 
Published: August 2018

ABSTRACT
The explosion of social and other digital media now provides virtually a continuous stream of information about organizations, their people, and their products. Although CEOs and others see the use of that social and digital information as a potential opportunity for creating value, they also recently have noted that one of the biggest risks organizations face is the potential threat to organizational and brand reputations from those same digital media. Accordingly, organizations are seeking out systems that allow them to continuously review and monitor social and other digital media in time to respond to both threats and opportunities. This paper presents a case study that investigates a system that is designed to monitor and mine the rapidly growing amounts of digital data to help banks better understand changes taking place in their worlds—regarding their products, reputations, clients, vendors, competitors, and others. Critical decisions must be made on what issues, people, and products to monitor, what digital sources to monitor, and what to do whenever some potential problem is found. The purpose of this paper is to investigate issues associated with implementing continuous monitoring systems for brand and reputation in financial organizations, with a particular focus on the “information behavior” (Feldman and March 1981) of such systems. In particular, the computer science in continuous monitoring systems seems to be ahead of actual use of such systems in organizations. As a result, although continuous monitoring systems can help companies address the mechanics of “how to do continuous monitoring,” there are many open questions and implementation issues in the actual use of such systems. As a result, this paper first provides a brief background of digital disruption, some digital risks, and continuous monitoring systems. Second, the paper examines the structure and design of a system in a banking context, investigating the key system design capabilities associated with such systems. In particular, we page through different screen artifacts to gain an understanding of how the system works. Third, we examine some of the issues facing a CIO as she seeks a system to meet the bank's digital needs.
AN INVESTIGATION INTO THE CONTENT VALIDITY OF A VIETNAMESE STANDARDIZED TEST OF ENGLISH PROFICIENCY (VSTEP.3-5) READING TEST
Authors: Thao Nguyen Thi Phuong 
Published: August 2018

This paper investigated the content validity of a Vietnamese Standardized Test of English Proficiency (VSTEP.3-5) Reading test via both qualitative and quantitative methods. The aim of the study is to evaluate the relevance and the coverage of the content in this test compared with the description in the test specification and the actual performance of examinees. With the content analysis provided by three testing experts using Bachman and Palmer’s 1996 framework and test score analysis, the study results in a relatively high consistency of the test content with the test design framework and the test takers’ performance. These findings help confirm the content validity of the specific investigated test paper. However, a need for content review is raised from the research as some problems have been revealed from the analysis.
METHOD OF SMS BASIC ELEMENTS DEVELOPMENT FOR THE AERODROME OPERATOR
Authors: Tolstykh S. A. , Sharov V. D. 
Published: August 2018

In developing and implementing the safety management System (SMS), which is mandatory in accordance with ICAO SARPs and the requirements of the air legislation of the Russian Federation, civil aviation aerodrome operators face methodological problems mainly in two components of the SMS – risk management and calculation of the safety performance indicators. To solve these problems, the article proposes to use a new approach for risk management in the airlines, developed by the Airline Risk Management Solution Group (ARMS). When adapting the method to the activities of the airport operator, the specifics of aviation events at the airport are taken into account. Manifestations of hazard factors in the form of events and deviations from the norms are proposed to be structured in accordance with the classification of activities in ground handling according to ISAGO Manual. A method for calculating and monitoring the safety performance indicator for the airport operator having extremely rare aviation events is proposed. The advantages of the ARMS approach in the implementation of the main prognostic part of the risk assessment, which directly considers the ability of the system to counteract the dangerous situation under the influence of hazards are shown. A threelevel scheme of safety management at the airport is proposed. The method proposed in the article was used as a basis for SMS implemented at two international aerodromes of the Russian Federation.
KOHERENSI DALAM WACANA CAKCUK
Authors: Subiyatningsih Foriyani - 
Published: August 2018

Kajian mengenai Koherensi dalam Wacana CakCuk ini bertujuan mendeskripsikan bagaimanakah hubungan makna atau koherensi pada wacana CakCuk? Pendekatan yang digunakan adalah deskriptif kualitatif. Data penelitian ini berupa data lingual dalam bentuk wacana tekstual yang diidentifikasi sebagai plesetan wacana CakCuk. Sumber data ini adalah counter yang khusus menjual aneka suvenir CakCuk di Surabaya. Pengumpulan data dilakukan dengan menggunakan metode simak dan metode cakap. Analisis data menggunakan metode agih, metode komparatif, dan metode padan kontekstual. Hasil analisis hubungan makna antarelemen atau koherensi dalam wacana CakCuk diperoleh simpulan sebagai berikut. Pertama, dari aspek semantik, proposisi-proposisi diurutkan dengan berbagai hubungan, yaitu hubungan kausalitas, hubungan amplifikatif, hubungan parafrastis, identifikasi, perbandingan, dan hubungan latar-kesimpulan. Kedua, berdasarkan kesatuan latar belakang semantis berupa inferensi dan referensi, entailment, praanggapan (presupposition), dan implikatur percakapan (conversational implicature)
Kinetic Study of Methyl Green Dye Adsorption from Aqueous Solution by Bauxite Clay at Different Temperatures
Authors: Abbas Ahmed Mohammed , Abd Suha Sahib , Himdan Takialdin abdulhadi 
Published: August 2018

Kinetic experiments were performed to induce of the green methyl dye adsorption from aqueous solution on the bauxite clay. This study includes determination of the adsorption capacity of bauxite clay to methyl green dye adsorption and study the effect of some parameters ( temperature , time ) on the kinetic of the adsorption process of the dye were studied. Quantity of dye adsorbed was increased when the temperature increases from 298 to 318K which indicates that methyl green adsorption processes are endothermic nature . In order to describe the kinetic data and the rate adsorption constants of the pseudo-first-order and second-order kinetics were used . The kinetics data were applied well with the second-order kinetic model. From activation energy value (Ea) for methyl green dye are energetically favorable and the dye adsorption includes physical and chemical adsorption types
Swelling Behavior and Drug Release of Interpenetrating Network Composed of PVA and Chitosan
Authors: Matty Fathel S. , MohiALDeen Zainab M. 
Published: August 2018

PVA and chitosan biodegradable, non-toxic, biocompatible polymers convenient for use in drug release.
In this study polyvinyl alcohol (PVA) and chitosan (CS) hydrogels crosslinked with glutaraldehyde (GA) with different ratio morphology and structure characterization interpenetrating polymer network (IPN).They were investigated by Fourier transmission infrared spectroscopy (FTIR), scanning electron microscope (SEM), UV-Visible spectrophotometer,swelling of hydrogel and drug release were studied by changing crosslinking ratio and PH.
Isolation and Characterization of Microcrystalline Cellulose and Preparation of Nano-Crystalline Cellulose from Tropical Water Hyacinth
Authors: Abdul Latif Mohammed H. , Mahmood Yasir Fathi 
Published: August 2018

Because of the conservation problems causes by the existence of water hyacinth (W.H) as an watery plant in water bodies of Iraq, our study aimed to make use of (W.H) by isolation of microcrystalline cellulose, and a new method of preparation of Nano crystalline cellulose. Microcrystalline cellulose was produced using base bleaching method by sodium hypochlorite [NaOCl] to remove unorganized region of cellulose and lignin to create particles comprising of micro crystal and preparing of Nano crystalline cellulose from microcrystalline cellulose by acid hydrolysis and ultrasonic treatment. The Nano crystalline and microcrystalline cellulose characterized by AFM, FTIR, XRD and TGA. FT-IR spectra of microcrystalline cellules and Nano crystalline cellulose show peaks at (1076.28, 1058.92) cm-1 and (1118.71, 1112.93) cm-1 refer to the stretching vibration of Câ€“O and stretching vibration intermolecular ester bonding.
The AFM image shows that isolated microcrystalline cellulose have a diameter of (141.37 nm) and the prepared Nano crystalline have a diameter of (87.39 nm). The Thermo gravimetric analysis of cellulose showed a high decomposition temperature at (283Â°C) for microcrystalline cellulose and (253)Â°C for Nano crystalline cellulose .The thermal stability of microcrystalline cellulose was more than Nano crystalline cellulose XRD result possessed a segal crystallinity index of 92.8 % and a average crystal size of 41.7 A Â° for Nano crystalline cellulose and a Segal Crystallinity Index of 86.4 % and a average crystal size of 55.3Â°A of microcrystalline cellulose.
¿Conciencia? ¿Qué conciencia?
Authors: Meana Elba 
Published: August 2018

<p>En el epígrafe el semiólogo francés hace referencia al segundo mensaje que siempre es posible leer en todo texto escrito, más aún los artículos periodísticos (cargados de intencionalidad implícita) y todavía más, si se trata, como en este caso, de un diario oficialista, como lo es el diario “La nación”, en el que se verá palmariamente cómo desde el poder se legitiman (a la par de suministrar información) decisiones de política pública, con fundamentos incomprobables, y dejando de lado un terreno fértil, una historia, antes transitados y que aún están siendo ejercidos. No será tan fácil, como oficiosamente se anuncia, desandar ese sendero. Básicamente porque está cargado de una subjetivación muy valorada hasta nuevo fundado aviso, por parte del sector docente.</p><p> </p>
Effect of temper rolling and subsequent annealing on texture development and magnetic permeability of semi-processed electrical steel with 2.3 wt.% Si
Authors: Ahmadian Peyman , Akbarzadeh Abbas 
Published: August 2018

Abstract
The effect of temper rolling and subsequent annealing on texture development and magnetic properties of semi-processed non grain oriented electrical steel has been investigated. The result shows that 5% temper rolling and final annealing at 850°C resulted in strong α-fiber component. The etch-pit technique shows that strain induced boundary migration is responsible for new texture component augmentation. Vibrating sample magnetometery reveals that maximum and minimum magnetic permeability are related to rolling and transverse directions, respectively. Average magnetic permeability is improved to some extent as a result of temper rolling and subsequent annealing.
Effect of heat treatment on the precipitation hardening in FeNiCoAlTaB shape memory alloys
Authors: Chulist R. , Prokopowicz M. , Maziarz W. , Ostachowski P. , Schell N. 
Published: August 2018

Abstract
In order to obtain optimal mechanical properties, the effect of heat treatment on the precipitation hardening in multicomponent Fe-based shape memory alloys (containing Ni, Co, Al, Ta, B) was studied. The polycrystalline material was investigated after application of three different processing schemas: slowly cooled, quenched and subsequently annealed with various aging conditions. The study was carried out using synchrotron X-ray diffraction along with mechanical tests, revealing the evolution of strengthening phases. As a result an optimum heat treatment for 10 h at 700°C was established yielding an optimal mechanical response.
Compressive behavior of double-layered functionally graded 316L stainless steel foam
Authors: Mirzaei Morteza , Paydar Mohammad Hossein 
Published: August 2018

Abstract
In this study, double-layer structured 316L stainless steel foam is fabricated through a layer by layer space holder method. The fabricated foams contain uniform pore distribution and can be categorized as body centered cubic crystal structures. Each sample is made of two layers in the axial direction. To induce 51 vol.% and 62 vol.% porosity in the first and the second layers, 1.7 to 2.0 mm and 2.0 to 2.4 mm spherical carbamide particles are used, respectively. In this study, the effect of the height of each layer on the compressive behavior of the fabricated foams is investigated in detail. The results indicate that compressive deformation of the double-layered foams starts from the high porosity (62 vol.%) layer and then shifts to the low porosity (51 vol.%) layer. Deformation of the double-layered 316L foams demonstrates two plateau regions, whose lengths depend on the heights of the low and high porosity layers.
Microstructure and mechanical behavior of Mg–Y–Zn alloys with respect to varying content of LPSO phase
Authors: Guo Yan-ping , Wang Ya-ning , Zhang Min-gang , Zhang Yue-zhong , Fang Da-qing , Wei Ying-hui , Liu Bao-sheng 
Published: August 2018

Abstract
Mg–Y–Zn alloys with different contents of alloying elements were prepared. The microstructure and mechanical properties of these Mg–Y–Zn alloys were investigated by using scanning electron microscopy, X-ray diffraction and tensile testing. The results show that the as-cast Mg–Y–Zn alloy is mainly composed of α-Mg, Mg12YZn and Mg3Y2Zn3 phases. After Mn addition, a small quantity of Mn phase arises in the as-cast Mg–Y–Zn–Mn alloy. After extrusion, the microstructure of the alloys is of an inhomogeneous character showing fine grains produced due to dynamic recrystallization. Tensile strength of as-extruded Mg-9Y-1Zn, Mg-9Y-3Zn and Mg-9Y-3Zn-1Mn reached 249.86 MPa, 303.19 MPa and 322.15 MPa, respectively. The gradually increasing strength can be attributed to fine grain strengthening, second phase strengthening and LPSO structure. Additionally, the tensile fracture surfaces were examined under scanning electron microscopy, and all of their fracture morphologies exhibit dimple facture character.