bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors involved in the clinical profile of carpal tunnel syndrome
Authors: Puchalski Piotr , Zyluk Paulina , Szlosser Zbigniew , Zyluk Andrzej 
Published: March 2018

AbstractClinical presentation of carpal tunnel syndrome may differ in relation to certain factors like sex, age, duration of symptoms and severity of compression. The
objective of this study was an investigation into the hypothesis that several distinct factors are predictive of the clinical profile for the condition. The
records of 1,117 patients: 909 women (81 %) and 208 men (19 %) with a mean age of 63 years, were analysed. The whole group was divided into subgroups, depending
on the variables analysed: sex, age, duration of the condition, severity of symptoms, severity of electrophysiological abnormalities and occurrence or lack of
comorbidities. Results. Of all the considered variables, the Levine symptom scores had the greatest impact on the condition’s clinical profile: the higher
scores the more severe pain, poorer sensation, weaker grip and worse hand function. Also, ages greater than 80 years had a significant negative effect on most
of the considered parameters. None of the remaining analysed variables had a substantial impact on the clinical profile of the condition.
Osteitis fibrosa cystica an der Hand: eine seltene, aber wichtige Differentialdiagnose
Authors: Spicher Rüdiger , Patzelt Thomas , Bauer Hans-Joachim 
Published: March 2018

EinleitungDer primäre Hyperparathyreodismus ist die zweithäufigste Knochenstoffwechselerkrankung (25–28 auf 100 000/Jahr) nach der Osteoporose 1. In ca. 80 % der Fälle liegt ursächlich ein Nebenschilddrüsenadenom zugrunde. Erhöhte Parathormon-Titer führen durch Osteoklastenaktivierung zu
Hypercalci- und Hypophosphatämie 2. Undiagnostiziert und unbehandelt kann es neben vielfältigen anderen Symptomen (z. B.
Nierensteine, Magenulcera) zu überschießenden Knochenresorptionen mit Ausbildung von Knochentumoren (sog. „braune Tumoren“) kommen. Diese betreffen gerade auch die
Hand und können die Stabilität gefährden. Für die Erkrankung existieren verschiedene Synonyme, so u. a. „Osteodystrophia fibrosa“ oder im englischen Sprachraum
„von-Recklinghausen`s disease of bone“.
Safety of lumen-apposing stent with or without coaxial plastic stent for endoscopic ultrasound-guided drainage of pancreatic fluid collections: a retrospective study
Authors: Puga Manuel , Consiglieri Claudia , Busquets Juli , Pallarès Natàlia , Secanella Lluis , Peláez Nuria , Fabregat Joan , Castellote José , Gornals Joan 
Published: March 2018

Abstract
Background The aim of this study was to evaluate whether the placement of a coaxial double-pigtail plastic stent (DPS) within a lumen-apposing metal stent (LAMS) may improve the safety of endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFCs).
Methods This was a retrospective cohort study including patients with PFCs and an indication for transmural drainage. Two strategies (LAMS alone or LAMS plus DPS) were used at the endoscopist’s discretion.
Results A total of 41 patients were treated (21 LAMS alone; 20 LAMS plus DPS). The characteristics of the PFCs, and the technical and clinical success rates did not differ between groups. The LAMS alone group had a significantly higher rate of adverse events than the LAMS plus DPS group (42.9 % vs. 10.0 %; P = 0.04). Bleeding was the most frequent adverse event observed.
Conclusions The addition of a coaxial DPS to LAMS was associated with a lower rate of adverse events in EUS-guided drainage of PFCs.
Epidemiological Profile of Intracerebral Hemorrhage during a 10-Year Period in a Southern Brazilian Region
Authors: Almeida Timóteo , Almeida Fernanda , Giacomini Luidia , Niederauer Andressa , Cho Anna , Mallmann Adroaldo , Camelo Ricardo , Bertolin Telma 
Published: March 2018

Objective Spontaneous intracerebral hemorrhage is responsible for 20% of all cases of cerebrovascular accidents, which might lead to functional disabilities and death. There are few epidemiological data on spontaneous intracerebral hemorrhage in Brazil, and more specifically in the southern region of the country.
Methods We reviewed data of 221 patients with intracerebral hemorrhage who attended our department between January of 2004 and December of 2013 and were registered as I61 and I62 according to the 10th edition of the International Classification of Diseases and Related Health Problems (ICD-10).
Results From the 221 cases, 53.8% were male, and the median age was 63 years old. Arterial hypertension was reported in 62.4% of the patients. Surgical treatment was performed in 28.9% of all cases and pneumonia affected 19.9%. In 73.4% of the cases, the patients died or were severely disabled at discharge. We found an association of heart disease, coagulopathies, chronic kidney disease, anticoagulant drugs use, surgical treatment, and pneumonia with a poorer outcome.
Conclusion The present study describes the epidemiological profile of intracerebral hemorrhage in a southern Brazilian population during a 10-year period.
CT-ADP Point-of-Care Assay Predicts 30-Day Paravalvular Aortic Regurgitation and Bleeding Events following Transcatheter Aortic Valve Replacement
Authors: Kibler Marion , Marchandot Benjamin , Messas Nathan , Caspar Thibault , Vincent Flavien , Von Hunolstein Jean-Jacques , Grunebaum Lelia , Reydel Antje , Rauch Antoine , Crimizade Ulun , Kindo Michel , Hoang Minh Tam , Trinh Annie , Petit-Eisenmann Hélène , De Poli Fabien , Leddet Pierre , Jesel Laurence , Ohlmann Patrick , Susen Sophie , Van Belle Eric , Morel Olivier 
Published: March 2018

Background Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recent data have emphasized the value of a point-of-care measure of von Willebrand factor–dependent platelet function (closure time [CT] adenosine diphosphate [ADP]) in the monitoring of immediate PVAR. This study examined whether CT-ADP could detect PVAR at 30 days and bleeding complications following TAVR.
Methods CT-ADP was assessed at baseline and the day after the procedure. At 30 days, significant PVAR was defined as a circumferential extent of regurgitation more than 10% by transthoracic echocardiography. Events at follow-up were assessed according to the Valve Academic Research Consortium-2 consensus classification.
Results Significant PVAR was diagnosed in 44 out of 219 patients (20.1%). Important reduction of CT-ADP could be found in patients without PVAR, contrasting with the lack of CT-ADP improvement in significant PVAR patients. By multivariate analysis, CT-ADP > 180 seconds (hazard ratio [HR]: 5.1, 95% confidence interval [CI]: 2.5–10.6; p < 0.001) and a self-expandable valve were the sole independent predictors of 30-day PVAR. At follow-up, postprocedural CT-ADP >180 seconds was identified as an independent predictor of major/life-threatening bleeding (HR: 1.7, 95% CI [1.0–3.1]; p = 0.049). Major/life-threatening bleedings were at their highest levels in patients with postprocedural CT-ADP > 180 seconds (35.2 vs. 18.8%; p = 0.013).
Conclusion Postprocedural CT-ADP > 180 seconds is an independent predictor of significant PVAR 30 days after TAVR and may independently contribute to major/life-threatening bleedings.
Different Manifestations of Rare Cases of Unruptured Sinus of Valsalva Aneurysm—Case Series and Literature Review
Authors: Pandit Bhagya Narayan , Subramaniyan Siva , Kumar Tarun , Agrawal Richa , Vatsa Deepankar 
Published: March 2018

AbstractSinus of Valsalva aneurysm (SVA) is rare, and aneurysm of the left sinus of Valsalva is extremely rare cardiovascular disease. Clinical presentation can vary from mostly asymptomatic to catastrophic life-threatening emergency. We report four extremely rare cases of SVA with different manifestations of which one case involved left aortic sinus with large unruptured aneurysm causing severe mitral regurgitation (MR) and severe aortic regurgitation (AR). The second case aneurysm was from right sinus presented with trifascicular block with intermittent complete heart block (CHB). Third was a diagnosed case of unruptured right SVA and while awaiting for surgery he had sudden cardiac death (SCD) at home. Therefore, SVA can present from asymptomatic to life-threatening condition, such as SCD. To the best of our knowledge, there are individual case reports in literature, and this is the first case series of unruptured SVA in literature highlighting the rarity of this disease.
Bildgebung in der Schwangerschaft
Authors: Loose Reinhard , Wucherer Michael 
Published: March 2018

ZusammenfassungEs gibt immer wieder klinische Situationen, in denen die radiologische Bildgebung während der Schwangerschaft unumgänglich ist. Typische Beispiele sind internistische oder chirurgische Notfälle, insbesondere Unfälle. Bei einer streng gestellten, rechtfertigenden Indikation unter Einbeziehung von Ultraschall und MRT als Alternativen ist bei den meisten Untersuchungen das Risiko der Strahlenanwendung gegenüber dem Nutzen zu vernachlässigen.
Prenatally Diagnosed Single Umbilical Artery (SUA) – Retrospective Analysis of 1169 Fetuses
Authors: Friebe-Hoffmann Ulrike , Hiltmann Andreas , Friedl Thomas , Lato Krisztian , Hammer Rüdiger , Janni Wolfgang , Kozlowski Peter 
Published: March 2018

Abstract
Purpose The incidence of a fetal single umbilical artery (SUA) is about 0.5 % and has been associated with an increased risk of congenital malformations, fetal aneuploidy and intrauterine growth restriction (IUGR).
Materials and Methods A retrospective analysis of 1169 women with singleton pregnancies diagnosed with fetal SUA between 1997 and 2014 in a specialized practice for prenatal diagnostics has been performed. Data was obtained on maternal and fetal findings as well as pregnancy outcome.
Results 989 (84.6 %) fetuses showed an isolated SUA (iSUA) while 180 (15.4 %) presented with SUA and additional structural and/or chromosomal abnormalities. Structural malformations were distributed as follows: 9.0 % cardiovascular, 3.5 % urogenital, 2.9 % musculoskeletal, 3.0 % gastrointestinal and 2.1 % cerebral. 2.1 % of the fetuses had chromosomal aberrations. 50.8 % (49.2 %) of the fetuses were female (male) and right vs. left SUA was found in 64.2 % (35.8 %) of the cases. Fetuses with SUA and additional abnormalities showed lower rates of live births (85.0 % vs. 98.5 %, p < 0.001), a lower median birth weight (2825 g vs. 3220 g, p < 0.001), higher rates of preterm delivery before week 34 + 0 (13.7 % vs. 3.8 %, p < 0.001) and weighed less than the 5th growth percentile in 21.6 % vs. 9.3 % (p < 0.001) of the fetuses with iSUA. In 5.1 % (60) of the children, chromosomal or structural abnormalities were detected post-partum.
Conclusion Once fetal SUA is diagnosed, intense sonoanatomy of the fetus is required and, if associated malformations are found, genetic testing must be offered. In iSUA intermittent biometry is recommended for the early detection of IUGR but additional genetic testing is not necessarily recommended.
Skin Ulceration of Eyelids in Atopic Dermatitis
Authors: Plattner Kim , Tschopp Markus , Todorova Margarita 
Published: March 2018

Abstract
Background Superinfection of atopic dermatitis due to a disturbed skin barrier is well known. Still, affected eyelids with ulceration are rarely described. We present a case series of three patients in different stages of upper eyelid superinfection.
History and Signs Three males aged 58, 37, and 52 years with clinical symptomatology of gradual expansion of eyelid ulcerations, crusts, and pus were evaluated. In all cases a standard ophthalmologic examination, including a detailed neuro-ophthalmological status, was performed. Consequently, a skin swab was obtained.
Therapy and Outcome The completed neuro-ophthalmological status and posterior segment findings were unremarkable in all patients. The skin swab results confirmed the presence of Streptococcus pyogenes, Staphylococcus epidermidis, and Staphylococcus aureus, thus necessitating antibiotic therapy.
Conclusions Superinfected atopic dermatitis can develop massive ulcerations, indicating a swap and empiric therapy. A complete neuro-ophthalmological status is mandatory to exclude the possibility of orbital involvement. Nevertheless, any paradoxical worsening of symptomatology indicates further referral to a dermatologist.
Comparative Study of the Usefulness of the Binocular Spot Vision Screener Autorefractor in the Detection of Childhood Visual Disorders
Authors: Voide Nathalie , Hoeckele Nicole , Kaeser Pierre-François 
Published: March 2018

Abstract
Background The Spot Vision Screener (SVS) is designed to detect significant ametropia, anisometropia, and strabismus in non-dilated eyes. This study evaluates the efficacy of the SVS in paediatric visual screening.
Patients and Methods All children screened during the paediatric visual screening day in Lausanne in 2016 were evaluated with the SVS, conventional monocular autorefractors, and clinical orthoptic examination. Recommendations for a further eye examination of the SVS were compared with those issued from traditional clinical screenings (monocular refraction and orthoptic examination).
Results One hundred and sixty-eight consecutive children were included. The median age was 3.9 years. The SVS median spherical equivalent (SE) was + 0.25 D OU and it detected seven cases of (4.2%) anisometropia (SE difference ≥ 1 D). The conventional monocular autorefractor median SE was − 0.13 D OU and 20 cases of anisometropia (11.9%) were detected. Refraction could not be measured in 1.2% of patients with SVS versus 17.2% with monocular refractors. The SVS screened two manifest strabismus cases against five manifest and > 100 latent strabismus with orthoptic examination. As expected, the SVS was unable to assess reactions to monocular occlusion, visual acuity, and stereovision as well as to detect ocular motility disorders without strabismus in the primary position, and missed two cases of abnormal Brückner reflexes. Overall, the SVS identified 66 suspect patients (39.3%) against 102 (60.7%) after complete clinical examination.
Conclusions The SVS can be a useful objective screening tool for non-ophthalmologists. However, because it fails to detect ocular motility troubles, organic visual acuity loss, or to assess the visual potential, it should only be used in association with a clinical examination, even in routine screening procedures.
Indikatoren der Ergebnisqualität kardiologischer Rehabilitation
Authors: Salzwedel Annett , Haubold Kathrin , Barnack Beate , Reibis Rona , Völler Heinz 
Published: March 2018

Zusammenfassung
Ziel der Studie Die vorliegende Untersuchung beinhaltete die explorative Erfassung potenzieller Indikatoren der Ergebnisqualität der kardiologischen Rehabilitation (CR) für Patienten unter 65 Jahren.
Methoden In einer 4-stufigen webbasierten Delphi-Befragung (04-07/2016) von in der CR tätigen Ärzten2 , Psychologen und Sport-/Physiotherapeuten wurden Parameter der körperlichen Leistungsfähigkeit, der Sozialmedizin, der subjektiven Gesundheit und kardiovaskuläre Risikofaktoren hinsichtlich ihrer Eignung als Qualitätsindikator bewertet.
Ergebnisse Von 44 vorgegebenen wie auch von den Teilnehmern vorgeschlagenen Parametern wurden 21 Parameter (48%), die Hälfte davon psychosoziale Faktoren, als potenzielle Qualitätsindikatoren ausgewählt, wobei lediglich für das Rauchverhalten, den Blutdruck, das LDL-Cholesterin und die max. Belastbarkeit im Belastungs-EKG ein Konsens (Zustimmung>75% der Befragten) erzielt wurde.
Schlussfolgerung Die Wahl der Qualitätsindikatoren durch die Experten erfolgte mehrheitlich mit nur geringer Einigkeit. Eine klinische und wissenschaftliche Evaluierung der gewählten Parameter ist daher zwingend erforderlich.
Hylomorphism without forms? A critical notice of Simon Evnine’s Making Objects and Events
Authors: Raven Michael J. 
Published: March 2018

AbstractSimon Evnine’s Making Objects and Events: A Hylomorphic Theory of Artifacts develops amorphic hylomorphism. I critically discuss three of its main themes. One theme is its attempt to do the work of form without forms. A second theme is the requirement that hylomorphs have ‘metabolisms at work’. A third theme is the use of artifacts as the paradigms for hylomorphs. I will raise some criticisms of each of these themes. Although the themes might at first appear disconnected, I believe the third underwrites the first two. So the criticisms of the third theme also bear on the rest.
Digital Rock Physics Aplications: Visualisation Complex Pore and Porosity-Permeability Estimations of the Porous Sandstone Reservoir
Authors: Handoyo  , Fatkhan  , Del Fourier 
Published: March 2018

Abstract
Reservoir rock containing oil and gas generally has high porosity and permeability. High porosity is expected to accommodate hydrocarbon fluid in large quantities and high permeability is associated with the rock’s ability to let hydrocarbon fluid flow optimally. Porosity and permeability measurement of a rock sample is usually performed in the laboratory. We estimate the porosity and permeability of sandstones digitally by using digital images from μCT-Scan. Advantages of the method are non-destructive and can be applied for small rock pieces also easily to construct the model. The porosity values are calculated by comparing the digital image of the pore volume to the total volume of the sandstones; while the permeability values are calculated using the Lattice Boltzmann calculations utilizing the nature of the law of conservation of mass and conservation of momentum of a particle. To determine variations of the porosity and permeability, the main sandstone samples with a dimension of 300 × 300 × 300 pixels are made into eight sub-cubes with a size of 150 × 150 × 150 pixels. Results of digital image modeling fluid flow velocity are visualized as normal velocity (streamline). Variations in value sandstone porosity vary between 0.30 to 0.38 and permeability variations in the range of 4000 mD to 6200 mD. The results of calculations show that the sandstone sample in this research is highly porous and permeable. The method combined with rock physics can be powerful tools for determining rock properties from small rock fragments.
PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
Authors: Ding Zufeng , Liu Shijie , Wang Xianwei , Theus Sue , Deng Xiaoyan , Fan Yubo , Zhou Sichang , Mehta Jawahar L 
Published: March 2018

Abstract

Aims
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to influence macrophage biology and modulate atherogenesis. We conducted this study to examine the regulation of scavenger receptors (SRs) (LOX-1, SRA, and CD36) and oxidized liporoptein cholesterol (ox-LDL) uptake in macrophages by PCSK9.

Methods and results
Treatment of mouse peritoneal macrophages with tumour necrosis factor alpha (TNF-α) resulted in concentration-dependent modest, but significant, increase in PCSK9 expression. Importantly, treatment of TNF-α primed macrophages with recombinant murine PCSK9 increased the expression of LOX-1, SRA, and CD36 2-5 fold, and enhanced ox-LDL uptake by ≈five-fold. The increase in LOX-1 was much greater than in SRA or CD36. PCSK9 inhibition (by siRNA transfection or use of macrophages from PCSK9−/− mice) reduced the expression of SRs (LOX-1 ≫ SRA or CD36). Ox-LDL uptake in response to PCSK9 was also inhibited in macrophages from LOX-1−/− mice (P &lt; 0.05 vs. macrophages from SRA−/− and CD36−/− mice). Upregulation of PCSK9 by cDNA transfection induced intense ox-LDL uptake which was inhibited by co-transfection of cells with siRNA LOX-1 (P &lt; 0.05 vs. siRNA SRA or siRNA CD36). Further, TNF-α-mediated PCSK9 upregulation and subsequent expression of SRs and ox-LDL uptake were reduced in macrophages from gp91phox−/−, p47phox−/− and p22phox−/− mice (vs. macrophages from wild-type mice).

Conclusions
This study shows that in an inflammatory milieu, elevated levels of PCSK9 potently stimulate the expression of SRs (principally LOX-1) and ox-LDL uptake in macrophages, and thus contribute to the process of atherogenesis.
Nerve Surgeons’ Assessment of the Role of Eduard Pernkopf's Atlas of Topographic and Applied Human Anatomy in Surgical Practice
Authors: Yee Andrew , Coombs Demetrius M , Hildebrandt Sabine , Seidelman William E , Coert J Henk , Mackinnon Susan E 
Published: March 2018

Abstract

BACKGROUND
Pernkopf's atlas of Anatomy contains anatomical plates with detailed images of the peripheral nerves. Its use is controversial due to the author's association with the “Third Reich” and the potential depiction of victims of the Holocaust. The ethical implications of using this atlas for informing surgical planning have not been assessed.

OBJECTIVE
To (1) assess the role of Pernkopf's atlas in nerve surgeons’ current practice and (2) determine whether a proposal for its ethical handling may provide possible guidance for use in surgery and surgical education.

METHODS
Members of American Society for Peripheral Nerve and PASSIO Education (video-based learning platform) were surveyed and 182 responses collected. The survey introduced the historical origin of Pernkopf's atlas, and respondents were asked whether they would use the atlas under specific conditions to serve as a recommendation for its ethical handling. An anatomical plate comparison between Netter's and Pernkopf's atlases was performed to compare anatomical accuracy and surgical utility.

RESULTS
Fifty-nine percent of respondents were aware of Pernkopf's atlas, with 13% currently using it. Aware of the historical facts, 69% were comfortable using the atlas, 15% uncomfortable, and 17% undecided. Additional information on conditions for an ethical approach to the use of the atlas led 76% of those “uncomfortable” and “undecided” to becoming “comfortable” with use.

CONCLUSION
While the use of Pernkopf's atlas remains controversial, a proposal detailing conditions for an ethical approach in its use provides new guidance in surgical planning and education.