bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undervaluation of rheumatoid arthritis activity under interleukin-6 inhibitor therapy
Authors: Ionescu Rosana Bristena , Doran Cristina , Moscalu Denisa Elena 
Published: April 2019

A 62-year-old female patient with advanced rheumatoid arthritis was admitted for assessment of disease activity. Patient was currently under treatment with Tocilizumab and Cyclosporine A (3mg/kg). Her history of hepatitis C and elevated transaminases (treated with Methotrexate) rendered her ineligible for this standard therapeutic option. Several other DMARDs (Azathioprine, Sulfasalazine, Hydroxychloroquine) and biological therapies (Etanercept, Certolizumab) had proven ineffective.
On admission, patient reported increased morning pain and stiffness of hand joints. Clinical examination revealed fourteen swollen joints with no tenderness at compression and typical signs of advanced rheumatoid arthritis: ulnar deviation of fingers, interosseous muscle atrophy, swan neck deformity, impaired prehension. Laboratory investigations showed normal CRP (1.83 mg/L) and slightly increased ESR (44 mm/h) values. DAS28-CRP=2.7 (low activity), DAS28-ESR=4.12 (moderate activity). Hand and wrist radiographs were characteristic of advanced stage disease: bone erosions, joint spaces narrowing, metacarpophalangeal subluxations, juxta-articular osteoporosis. Ultrasound of hand joints revealed signs of active disease with positive Doppler signal.
During hospitalisation the patient received pain relieving treatment (Dexamethasone, Lornoxicam). On discharge, Cyclosporine A dose was increased to 5mg/kg. The timeliness of a different biological treatment will be assessed after 3 months, in case of persistent disease activity.
The present case highlights the risk of disease activity undervaluation in patients undergoing biological therapy with interleukin-6 inhibitors if the standard DAS28-CRP score is used [1],[2],[3], due to their additional inhibitory effect on hepatic CRP production. It is advised that in such cases, articular ultrasound and DAS28-ESR score should be considered for a more accurate assessment.
Le droit des chercheurs à mettre leurs résultats de recherche en libre accès
Authors: Bosc Hélène 
Published: April 2019

Le développement d’Internet a permis à la communauté scientifique de prendre conscience de sondroit: celui de mettre en libre accès ses propres résultats de recherche. En 2002, un groupe dechercheurs et éditeurs a lancé la Budapest Open Access Initiative (BOAI). Il a formulé le concept dulibre accès (LA) et les deux stratégies pour y parvenir : déposer dans une archive ouverte le doubled’un article publié dans un périodique payé par souscription (« LA Vert »), et/ou publier dans unerevue en libre accès (« LA Doré »). Le concept du libre accès s’est rapidement étendu mais il ad’abord été presque complètement assimilé au seul « LA Doré ». L’auto-archivage a été négligé en dépit du fait que cette voie verte représente la possibilité de croissance du LA la plus immédiate et laplus rapide.Les efforts déployés alors (analyses stratégiques, études, développement d’outilstechniques pour créer des archives institutionnelles et mesurer leur impact) ont permis de démontrerl’importance et les avantages de l’auto-archivage. De ce fait le nombre d’archives a augmenté, toutcomme l’obligation d’auto-archiver dans les universités, les institutions et les fondations derecherche. Dans quelques pays, une politique d’auto-archivage a été proposée au niveau gouvernemental. Cet engagement des hommes politiques commence à inquiéter certains éditeursscientifiques, qui s’organisent en lobby anti-LA et réussissent dans certains cas à ralentir ou arrêterla législation. C’est pour cette raison que la communauté scientifique, moins vulnérable au lobby deséditeurs - que peuvent l’être les politiciens - prend l’initiative d’organiser une politique de LA avecl’obligation d’auto-archivage au niveau de l’université.
Risicoaansprakelijkheid voor ongeschikte medische hulpzaken
Authors: Hiemstra J.T. 
Published: April 2019

Risicoaansprakelijkheid voor ongeschikte medische hulpzaken
In haar recent verschenen proefschrift onderzoekt de auteur in hoeverre het risico dat voortvloeit uit het gebruik van ongeschikte medische hulpzaken voor rekening van de hulpverlener dient te komen. In dit artikel worden de belangrijkste bevindingen uit dit onderzoek uiteengezet. De auteur komt tot de conclusie dat het risico dat voortvloeit uit het gebruik van ongeschikte medische hulpzaken in beginsel voor rekening van de hulpverlener komt. De redelijkheid zal niet snel gebieden dat het risico dient te worden verschoven naar de patiënt.
Welke gevolgen kan deelfraude hebben voor de vordering van de claimant op de aansprakelijke partij en diens verzekeraar?
Authors: Keizer J.G. 
Published: April 2019

Welke gevolgen kan deelfraude hebben voor de vordering van de claimant op de aansprakelijke partij en diens verzekeraar?. HR 6 juli 2018, ECLI:NL:HR:2018:1103
De Hoge Raad heeft duidelijk gemaakt dat de regel uit het verzekeringsrecht dat (deel)fraude tot algeheel verval van het recht op uitkering kan leiden (art. 7:941 lid 5 BW), niet analoog toegepast kan worden in de personenschadepraktijk als de claimant tegenover de verzekeraar van de aansprakelijke partij (deel)fraude pleegt. Is een aan artikel 7:491 lid 5 BW verwante wettelijke regel voor de personenschadepraktijk daarom nodig en wenselijk, of bestaan er al voldoende mogelijkheden om (deel)fraude effectief te sanctioneren?
Aansprakelijkheidsrecht dient ook emotionele belangen
Authors: Opdam M. 
Published: April 2019

Aansprakelijkheidsrecht dient ook emotionele belangen. Hof Arnhem-Leeuwarden 15 mei 2018, ECLI:NL:GHARL:2018:4396
Een moeder heeft recht op inzage in het obductieverslag van haar overleden zoon. Het beroepsgeheim wordt doorbroken op grond van een zwaarwegend belang. Daarbij speelt ook het emotionele belang van de moeder om opheldering te krijgen over de doodsoorzaak een rol. Het aansprakelijkheidsrecht dient volgens het hof niet alleen een vergoedingsbelang, maar kan ook bijdragen aan de bevrediging van emotionele belangen. In deze annotatie wordt de waarde van een (zuiver) emotioneel belang in het aansprakelijkheidsrecht besproken.
Molecular Characterization of Lactic Acid Organisms Isolated from Spontaneous Fermentation of Cassava- fufu and gari
Authors: Ayoade Femi, , Fayemi Scott , Olukanni Olumide , Ogunbiyi Tosin , Oluniyi Paul 
Published: April 2019

Aim: The present work was aimed at ensuring the accurate taxonomic identification of the fermentation organisms previously isolated from spontaneously fermented cassava for the purpose of safety assessment and quality assurance.
Study Design: Purposive sampling method was used as all the five isolated organisms (from the previous study); 2 bacterial and 3 fungal organisms were characterized using molecular methods.
Place and Duration of Study: The genotypically characterized organisms are from a previous study carried out in May 2016 where lactic acid bacterial and fungal organisms were isolated from spontaneously fermented cassava.
Methodology: Genomic DNA was extracted from the lactic acid microorganisms and this was used as a template in a polymerase chain reaction (PCR) reaction. The 16s rRNA genes were amplified for the bacterial isolates while nuclear ribosomal internal transcribed spacer (ITS) genes were targeted for the fungal isolates. The amplicons were electrophoresed on 2% agarose gel prepared with Tris Borate Ethylenediamintetraacetate (TBE) buffers stained with ethidium bromide. The sizes of the corresponding amplicon captured on gel images were compared with that of the ladder to determine their sizes. Furthermore, sequences of the PCR products were analyzed and the chromatograms subjected to BLAST (Basic Local Alignment Search Tool) analyses to identify the lactic acid organisms.
Results: The 3 fungal isolates were identified as Schizophyllum commune (MK 431022), Aspergillus oryzae (MK434151), Aspergillus sydowii (MK434152), while the bacterial isolates were identified as Bacillus spp (MK450345) and Bacillus spp (MK 449018). A high level of discrepancies was observed when the results of identification of the same isolates by biochemical methods in an earlier report were compared with the results from the present study using molecular methods.
Conclusion: The identification and characterization of the isolates and the discrepancies between the outcomes of the biochemical and molecular methods underscore the limitations of phenotypic (biochemical) methods in characterizing organisms that may eventually be used as starter organisms in food fermentation. The present result makes quality assurance and safety assessment of foods prepared using these organisms as starter organisms possible.
Microbial Quality and Safety of Traditional Fermented Camel Milk Product Suusac Sampled from Different Regions in North Eastern, Kenya
Authors: Maitha Isaac M. , Kaindi Dasel W. M. , Wangoh John , Mbugua Samuel 
Published: April 2019

Aim: The study was carried out to assess the microbial quality and safety of fermented camel milk product (Suusac) from North Eastern Kenya.
Methodology: Twenty-eight samples (n=28) of Suusac from different areas of the region sold in informal markets at Eastleigh in Nairobi were aseptically collected at the sales points. The quality and safety of the Suusac with reference to selected pathogens namely E. coli, S. aureus, Shigella, and Klebsiella spp was evaluated using the standard analytical methods.
Results: Escherichia coli were detected in all the samples while Staphylococcus aureus was detected in 63.09% of the samples analyzed. Shigella spp was detected in 88.1% of the samples analyzed and Klebsiella spp was detected in 77.4% of the samples. The mean log10 counts for E. coli, S. aureus, Shigella, and Klebsiella spp were 3.135, 2.576, 2.784 and 3.138, CFUmL-1, respectively. There is a potential public health concern posed by Suusac which is sold for direct consumption due to the presence of the life-threatening bacterial pathogens.
Conclusion: The Suusac being sold at Eastleigh market in Nairobi from North Eastern Kenya may be responsible for transmission of the pathogens to the consumers. Training on food hygiene, improving production technology, hygienic conditions and implementing the food legislations along the value chain can minimize the risk.
Assessment of Production and Utilization of Black Cumin (Nigella sativa) at the Oromia Regional State, Ethiopia
Authors: Teshome Wubeshet , Anshiso Dessalegn 
Published: April 2019

Background and Objective: Black cuminseed for local consumption and other importance, such as oil and oil rosin for medicinal purposes, export market, crop diversification, income generation, reducing the risk of crop failure and others made it as a best alternative crop under Ethiopian smaller land holdings. The objectives of this study were to examine factors affecting farmer perception of the Black cumin production importance, and assess the crop utilization purpose by smallholder farmers and its income potential for the farmers in two Districts of Bale zone of Oromia regional state in Ethiopia.
Materials and Methods: The survey was conducted from January to May 2018 in two Districts of Oromia region. Questionnaires, focus group discussion and field observation were used to collect data. A total of 180 Black cumin producers were selected randomly from 8 Kebele’s. The responses were analyzed by using descriptive statistics and Probit model in Stata version 13.
Results: The survey result indicated that the majority (95.56%) of the households perceived that production of Black cumin crop is important. The crop used as source of better income, medicinal crop and spice in the study area. From the total mean of agriculture income, Black cumin production contributes about 39.88% to the income the respondents. The Probit model shows that producers perception of the importance of Black cumin production was found to be statistically and significant affected by age of households, education level, availability of labor for farm activities, access to credit facilities, average income from Black cumin, and its productivity level through time. Conclusion: The agricultural policy should give emphases at all operational level to exploit more benefit from this crop and on the production enhancement strategies, so as to bring foreseen change in the lives of the producers.
Play What, Like What! The Application of Psychodrama in the Business Management Education in Universities-Marketing Management as an Example
Authors: Lin Chih-Huang 
Published: April 2019

The higher education is facing challenges and the learning is flipping. The teaching as a whole-person is one of the major mission of higher education. Psychodrama was developed for psychotherapy and it is used as a psychotherapy technique in group counseling, consultation, and even education in recent years. In business schools, psychodrama offers a creative and more experiential way for students to explore and solve the key issues in business and management practice. This study uses psychodrama in teaching in the real Business-Management course Marketing Management 」as the research context.
This study is an action research in Business-Management education. This study is bringing a new learning experience to Business education. Moreover, it also adds humanistic quality and social consideration to students. With the qualitative and quantitative data, the results demonstrates that psychodrama can improve learning outcomes, enhance learning satisfaction, and even enhance the ability of students to business decision-making. Furthermore, this study also provides managerial and practical implications for both higher education in business schools and real world business managers.
Phenylthiocarbamide Taste Perception among Patients with Type 2 Diabetes Mellitus
Authors: Igbeneghu C. , Olisekodiaka J. M. , Onuegbu J. A. , Oyeyode O. H. 
Published: April 2019

Aim: To determine whether Phenylthiocarbamide (PTC) taste blindness is associated with type 2 Diabetes Mellitus (DM) and possible relationship between intake of treatment medications and PTC taste sensitivity.
Methodology: The study participants consisted of 100 type 2 DM patients on treatment (group 1) and 100 newly diagnosed type 2 DM patients not on drugs treatment (group 2). Apparently healthy individuals (100) served as controls (group 3). Informed consent was obtained from each participant at the commencement of the study. Tasters and non-tasters were determined using phenylthiocarbamide (PTC) taste strips (0.0143 mg/strip).
Results: In group 1, 66% were non-tasters; in group 2, 60% were non-tasters while 37% in group 3 were non-tasters. Phenylthiocarbamide taste perception varied significantly among the 3 groups studied (p < 0.001). Non-tasters of PTC in groups 1 and 2 were not significantly different (p = 0.38). Non-tasters of PTC in groups 1 and 2 (p < 0.001; OR 3.30 and p = 0.001; OR 2.55 respectively) were significantly higher than non-tasters in the control (group 3).
Conclusion: This study shows that inability to taste PTC is associated with type 2 DM. However, intake of DM treatment medications does not appear to have any significant influence on PTC taste sensitivity.
Wild Edible Mushrooms Depict a Dissimilar Biogeographical Distribution in Humid Forests of Cameroon
Authors: Onguene A. N. , Kuyper Th. W. 
Published: April 2019

For millennia, wild edible mushrooms (WEM) had always been considered as substantial food and medicinal sources, for local communities, both Bantu and indigenous peoples. However, few information and sparse data are available on useful mushrooms of Cameroon. A study was undertaken to update the checklist of WEM in humid forests of Cameroon. From mushroom excursions, surveys and inventories, thousand fungal specimens were collected in situ, described and identified using key features and references.
Wild edible mushrooms were recruited in three trophic groups. They denoted a dissimilar national biogeographical distribution. Saprophytes and Termitomyces were encountered throughout the country; ectomycorrhizal mushrooms occurred in forest clumps, only in three regions: South, Southeast and Southwest. 117 WEM were listed belonging to 17 families and 43 genera, including nearly 22 Termitomyces, 32 ectomycorrhizal and 63 saprophyte species. 15 WEM were also claimed to have medicinal properties. This vast mushroom diversity related to various specific habitats and ecological niches. Five fungal groups were considered as excellent edible. Amanita and Boletus species were seldom consumed. Most mushroom species were harvested solely for home consumption, with the exception of Termitomyces, the only marketed mushroom. In fine, the diversity of WEM was high but poorly known and valorized. To fulfill the Nagoya convention, it is recommended to pursue mycological inventory of macrofungi in Cameroon, including the use of molecular tools and to cultivate local wild edible saprophyte mushrooms.
Effect of Microbial Phytase on Nutrient Availability and Growth of Juvenile Clarias gariepinus Fed Soyabean and Groundnut-based Diets
Authors: Uzezi Akpoilih Benjamin , Kolawole Ajani Emmanuel , Oluwarotimi Omitoyin Bamidele 
Published: April 2019

Several studies have shown the positive effect of phytase on phosphorus utilization by fish and animals, with the use of phytase sources determined for different fish species. Few studies have tested phytase response to different diets, which may affect nutrient availability for optimum growth due to differences in phytate location. The research, therefore, studied the effect of phytase to diets based on soya bean and groundnut meal for Clarias gariepinus on nutrient availability and growth. In trial 1, four groups of soya bean S1, S2, S3 and S4 replaced fish meal at 25%, 50%, 75% and 100% and supplemented with 250, 500, 750 and 1000 FTU/g phytase, respectively. In trial 2, four groups of groundnut meal diet G1, G2, G3, G4, G5 and G6, were similarly supplemented with the same phytase levels used in experiment 1. Fish meal control (S0=G0) was not supplemented with phytase. Result showed that 250 FTU/g phytase showed the highest mean weight gain for both plants. In conclusion, the research has shown that the chemical nature of phytate, rather than its concentration and location, may influence the utilization of phosphorus for optimum growth in the fish by supplementing 250 FTU/g, with a range of available phosphorus requirement of between 0.75% (Y = 0.363 + 4.155X - 2.772X2, R2 = 0.759) and 0.80% (Y = 0.307 + 3.303X - 2.059X2, R2= 0.210)
Impacts of Social-Cultural Factors on the Management of Deep Pools of Likangala River, Malawi
Authors: Makwinja Rodgers , Chipofya Victor 
Published: April 2019

The study was conducted to analyse the impact of social cultural factors on the management of deep pools in Likangala River during Lake Chilwa recession period. A comprehensive survey which covered 120 households was carried out. Using logit analysis, the study showed that the use of local leaders, indigenous knowledge, initiation ceremony, age of the household heads, culture and traditional beliefs were significant factors affecting the management of the water resource in the pools. The study concluded that the sustainable management of water resource in the pools can be achieved by integration of scientific principles with indigenous knowledge, traditional beliefs and culture of the communities. The study further recommended the involvement of local leaders in policy formulation regarding integrated water resource management in order to achieve sustainable use and management of the water resource in Likangala River.
A Late Presenting Urachal Remnant Tumour: Rare Adenocarcinoma Originated from Developmental Defect
Authors: Dey Ipsita , Roy Chhaya , Kanti Das Tushar 
Published: April 2019

Occupying only 0.01% of all adult cancer patients, the rare entity urachal adenocarcinoma constitutes 22-35% of adenocarcinomas originating from urinary bladder. Though with the gradual descend of the bladder in the course of development urachus should turn into median umbilical ligament, exceptional persistence of it can give rise to urachal cyst or urachal adenocarcinoma in adulthood. With only 43% of survival rate for 5 years and mean survival between 12 and 24 months urachal carcinoma is a devastating disease. Diagnosis of it is based on the MD Anderson Cancer Centre (MDACC) criteria. Computed Tomography (CT) Scan and/or Magnetic Resonance Imaging (MRI) Scan of abdomen and pelvis are the major imaging modalities to proceed towards diagnosis and staging. Not only histopathological examination but also immune-histochemical expression of both CK7 and CK20 suffice to clinch the diagnosis. Though surgical intervention forms the mainstay of treatment, several regimens of chemotherapy have also been tried to fight against unresectable, residual, extensive urachal carcinomas.
This case took place in a 52 years old male patient who was presented with a gradually enhancing infra-umbilical swelling with slow growing urinary symptoms. By dint of Ultrasonography (USG) and Contrast Enhanced CT (CECT) scan of whole abdomen the tumour was detected involving the bladder wall and the anterior abdominal wall. Cystoscopy was followed by upfront cytoreductive surgery. Histopathological examination revealed the diagnosis of an adenocarcinoma which was further confirmed to be an urachal remnant carcinoma with the help of immunohistochemistry. Post-operative CT scan showed residual disease involving bladder wall and was treated with an adjuvant platin based chemotherapy regimen.
Face Recognition Using 2D-FLDA Based on Approximate SVD Obtained with Kronecker Products with One Training Sample
Authors: Turhal Ümit Çiğdem 
Published: April 2019

Aims: In a face recognition task, it is a challenging problem to find lots of images for a person. Even, sometimes there can be only one image, available for a person. In these cases many of the methods are exposed to serious performance drops even some of these fail to work. Recently this problem has become remarkable for researchers. In some of these studies the database is extended using a synthesized image which is constructed from the singular value decomposition (SVD) of the single training image. In this paper, for such a method, SVD based 2 Dimensional Fisher Linear Discriminant Analysis (2D-FLDA), it is proposed a new approach to find the SVD of the image matrix with the aim of to increase the recognition performance.
Study Design: In this paper, in a face recognition task with 2D-FLDA, in one training sample case, instead of original SVD of the image matrix, the approximate SVD of its based on multiple kronecker product sums is used. In order to obtain it, image matrix is first reshaped thus it is to be lower dimensional matrices and, then the sum of multiple kronecker products (MKPS) is applied in this lower dimensional space.
Methodology: Experiments are performed on two known databases Ar-Face and ORL face databases. The performance of the proposed method is evaluated when there are facial expression, lightning conditions and pose variations.
Results: In each experiment, the approximate SVD approach based on multiple kronecker product sum gets approximately 3% better results when compared with the original SVD.
Conclusion: Experimental results verify that the proposed method achieves better recognition performance over the traditional one. The reason for this is the proposed approximate SVD has the advantages of simplicity, and also as the kronecker factors possess additional linear structure, kronecker product can capture potential self-similarity.