bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global well-posedness of nonlinear wave equation with weak and strong damping terms and logarithmic source term
Authors: Lian Wei , Xu Runzhang 
Published: July 2019

Abstract
The main goal of this work is to investigate the initial boundary value problem of nonlinear wave equation with weak and strong damping terms and logarithmic term at three different initial energy levels, i.e., subcritical energy E(0) < d, critical initial energy E(0) = d and the arbitrary high initial energy E(0) > 0 (ω = 0). Firstly, we prove the local existence of weak solution by using contraction mapping principle. And in the framework of potential well, we show the global existence, energy decay and, unlike the power type nonlinearity, infinite time blow up of the solution with sub-critical initial energy. Then we parallelly extend all the conclusions for the subcritical case to the critical case by scaling technique. Besides, a high energy infinite time blow up result is established.
Certified reference material against PR3 ANCA IgG autoantibodies. From development to certification
Authors: Monogioudi Evanthia , Sheldon Joanna , Meroni Pier Luigi , Hutu Dana Petronela , Schimmel Heinz , Zegers Ingrid 
Published: July 2019

Abstract

Background
The importance of the standardisation of immunoassays for autoantibodies has been widely discussed. The appropriate use of certified reference materials (CRM) could contribute to a more accurate diagnosis and follow-up of a series of diseases such as small vessel-associated vasculitis. This is a systemic autoimmune disorder during which two autoantibodies can be present, MPO ANCA IgG and PR3 ANCA IgG. Results from different commercially available immunoassays used for PR3 ANCA IgG measurement can vary significantly. Therefore the potential for improvement using a suitable certified reference material was assessed and led to the development of a CRM.

Methods
Thirty clinical samples were evaluated using 10 immunoassays. The correlation between results from these assays was assessed in a pairwise manner. Feasibility studies were conducted in order to find a reference material format most suitable for the preparation of a CRM.

Results
The evaluation of two sets of 30 clinical samples with 10 assays showed that differences between assays can result in different interpretations for individual clinical samples. Most of the samples had the same result classification in all assays. However, six of the samples tested led to inconsistent results.

Conclusions
The correlation between results from clinical samples was systematically good for combinations of eight of those assays. Therefore, it should be possible to improve the comparability of results using a commutable CRM for calibration. Based on these studies, a final format for the CRM was selected and eventually produced and certified for its PR3 ANCA IgG content.
Comparison of five automated urine sediment analyzers with manual microscopy for accurate identification of urine sediment
Authors: Cho Jooyoung , Oh Kyeong Jin , Jeon Beom Chan , Lee Sang-Guk , Kim Jeong-Ho 
Published: July 2019

Abstract

Background
While the introduction of automated urine analyzers is expected to reduce the labor involved, turnaround time and potential assay variations, microscopic examination remains the “gold standard” for the analysis of urine sediments. In this study, we evaluated the analytical and diagnostic performance of five recently introduced automated urine sediment analyzers.

Methods
A total of 1016 samples were examined using five automated urine sediment analyzers and manual microscopy. Concordance of results from each automated analyzer and manual microscopy were evaluated. In addition, image and microscopic review rates of each system were investigated.

Results
The proportional bias for red blood cells (RBCs), white blood cells (WBCs) and squamous epithelial cells in the automated urine sediment analyzers were within ±20% of values obtained using the manual microscope, except in the cases of RBCs and WBCs analyzed using URiSCAN PlusScope and Iris iQ200SPRINT, respectively. The sensitivities of Roche Cobas® u 701 and Siemens UAS800 for pathologic casts (73.6% and 81.1%, respectively) and crystals (62.2% and 49.5%, respectively) were high, along with high image review rates (24.6% and 25.2%, respectively). The detection rates for crystals, casts and review rates can be changed for the Sysmex UF-5000 platform according to cut-off thresholds.

Conclusions
Each automated urine sediment analyzer has certain distinct features, in addition to the common advantages of reducing the burden of manual processing. Therefore, laboratory physicians are encouraged to understand these features, and to utilize each system in appropriate ways, considering clinical algorithms and laboratory workflow.
Evaluating the Performance of Newly Integrated Model in Nonlinear Chemical Process Against Missing Measurements
Authors: Mickel Vivianna Maria , Yeo Wan Sieng , Saptoro Agus 
Published: July 2019

AbstractApplication of data-driven soft sensors in manufacturing fields, for instance, chemical, pharmaceutical, and bioprocess have rapidly grown. The issue of missing measurements is common in chemical processing industries that involve data-driven soft sensors. Locally weighted Kernel partial least squares (LW-KPLS) algorithm has recently been proposed to develop adaptive soft sensors for nonlinear processes. This algorithm generally works well for complete datasets; however, it is unable to cope well with any datasets comprising missing measurements. Despite the above issue, limited studies can be found in assessing the effects of incomplete data and their treatment method on the predictive performances of LW-KPLS. To address these research gaps, therefore, a trimmed scores regression (TSR) based missing data imputation method was integrated to LW-KPLS to formulate trimmed scores regression assisted locally weighted Kernel partial least squares (TSR-LW-KPLS) model. In this study, this proposed TSR-LW-KPLS was employed to deal with missing measurements in nonlinear chemical process data. The performances of TSR-LW-KPLS were evaluated using three case studies having different percentages of missing measurements varying from 5 % to 40 %. The obtained results were then compared to the results from singular value decomposition assisted locally weighted Kernel partial least squares (SVD-LW-KPLS) model. SVD-LW-KPLS was also proposed by incorporating a singular value decomposition (SVD) based missing data treatment method into LW-KPLS. From the comparative studies, it is evident that the predictive accuracies of TSR-LW-KPLS are superior compared to the ones from SVD-LW-KPLS.
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines
Authors: Hlushchenko Iryna , Hotulainen Pirta 
Published: July 2019

Abstract
Synaptic plasticity underlies central brain functions, such as learning. Ca2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes. By identifying molecules, which can distinguish between signaling leading to weakening or strengthening, we can improve our understanding of how synaptic plasticity is regulated. Here, we tested gelsolin’s response to the induction of chemical long-term potentiation (cLTP) or long-term depression (cLTD) in cultured rat hippocampal neurons. We show that gelsolin relocates from the dendritic shaft to dendritic spines upon cLTD induction while it did not show any relocalization upon cLTP induction. Dendritic spines are small actin-rich protrusions on dendrites, where LTD/LTP-responsive excitatory synapses are located. We propose that the LTD-induced modest – but relatively long-lasting – elevation of Ca2+ concentration increases the affinity of gelsolin to F-actin. As F-actin is enriched in dendritic spines, it is probable that increased affinity to F-actin induces the relocalization of gelsolin.
The mediating role of difficulties in emotion regulation on attachment styles of adolescents with conduct disorders
Authors: Yaghoubipoor Mojtaba , Seyed Bagheri Seyed Hamid , Khoshab Hadi 
Published: July 2019

Abstract
Adolescence is a period of achieving emotion regulation skills. One of the main responsibilities of adolescents is to learn adaptive emotion regulation and personal autonomy. The purpose of this study was to investigate the mediating role of difficulties in emotion regulation in the attachment styles of adolescents with conduct disorders. This was a cross-sectional and correlational study. The study consisted of 105 adolescent residing in detention centers in the southeast of Iran using multi-stage random sampling. Data were collected using various questionnaires such as the Inventory of Parents and Peer Attachment-Revised (IPPA-R), the Difficulties of Emotion Regulation Scale (DERS), and the Strength and Difficulties Questionnaire (SDQ). Information was analyzed using path analysis. The results show parental attachment and difficulties in emotion regulation significantly contribute to the prediction of conduct problems. A sense of alienation causes conduct disorders through disturbance in emotional regulation, but trust and communication with parents are only indirectly related to conduct disorders by disturbances in emotional regulation. As attachment is closely correlated with emotional regulation and difficulties in emotion regulation also lead to the conduct disorders, it is suggested to train emotion regulation in adolescents and their families with the aim of shaping relationships that will lead to the formation of a secure attachment style in the child.
Electromyographic analysis of upper trapezius, abductor pollicis longus and abductor pollicis brevis during smartphone use in different positions among young male and female subjects
Authors: Irshad Nida , Raza Shahid , Moiz Jamal Ali , Mujaddadi Aqsa , Bhati Pooja 
Published: July 2019

Abstract

Background
Smartphone use has increased tremendously in recent times and there are various adverse musculoskeletal consequences associated with its use. Alteration in the activation patterns of muscles in certain positions may be the reason behind the development of musculoskeletal disorders in smartphone users; however, it has not been thoroughly investigated by the existing literature.

Objectives
To investigate the electromyographic (EMG) activity of upper trapezius (UT), abductor pollicis brevis (APB) and abductor pollicis longus (APL) during smartphone use in three different positions (standing, sitting on the chair and sitting cross legged on the floor) in young male versus female subjects.

Methods
Twenty-six young male (age: 23.77 ± 2.47 years) and 26 young female (age: 22.45 ± 2.32 years) smartphone users were recruited from Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India. EMG activity of UT, APB and APL muscles was examined using surface electrodes during a smartphone task in three different positions, i.e. standing, sitting on a chair, sitting cross-legged on the floor. The smartphone task consisted of typing English quotations for 20 s 3 times with a rest period of 10 s between each quotation and a 5-min interval between each position, respectively.

Results
EMG activity of the UT muscle was found to be significantly reduced when sitting on a chair as compared to standing (p < 0.001) and sitting cross-legged (p = 0.008) during smartphone use. APB and APL muscle activity were not significantly different between the three positions (p > 0.05). Moreover, the activation patterns of these muscles did not differ in male and female subjects (p > 0.05).

Conclusion
The present study demonstrates that the UT muscle is least activated when sitting on chair as compared to standing and sitting cross-legged during smartphone use. Moreover, the activity of neck and thumb muscles does not vary significantly between male and female subjects during smartphone use in different positions. As UT muscle activation significantly varies with the position of smartphone use, thus, the position adopted during smartphone use should be taken into consideration and the position which causes least strain on muscles, i.e. sitting on the chair should be adopted.
Ficus cunia Buch.-Ham. ex Roxb. (leaves): An experimental evaluation of the cytotoxicity, thrombolytic, analgesic and neuropharmacological activities of its methanol extract
Authors: Hasanat Abul , Kabir Mohammad Shah Hafez , Ansari Md. Alam , Chowdhury Tanvir Ahmad , Hossain Mohammed Munawar , Islam Mohammad Nazmul , Ahmed Shabbir , Chy Md. Nazim Uddin , Adnan Md. , Kamal A.T.M. Mostafa 
Published: July 2019

Abstract

Background
The aim of this experiment was to evaluate the cytotoxic, thrombolytic, analgesic, sedative-hypnotic and anxiolytic activities of the methanolic extract of Ficus cunia leaves.

Methods
Primary phytochemical screening was accomplished by using established methods. Cytotoxicity was studied by brine shrimp lethality test, and the thrombolytic assay was conducted through clot lysis method with human blood. The in vivo action was done using mice of both sexes. The analgesic activity was evaluated by acetic acid-induced writhing test and formalin-induced paw licking test. Open field, hole cross and thiopental Na-induced sleeping time test were used to examine the sedative-hypnotic activity, and elevated plus maze (EPM) and hole board test were used to identify the anxiolytic activity.

Results
The results elicited that the extract contained several phytochemicals such as alkaloid, flavonoid, and tannin. The extract was found to have a median lethal concentration (LC50) value of 55.48 μg/mL in the brine shrimp lethality bioassay. It was also assessed for antithrombotic activity when compared with streptokinase; it has significant (p < 0.001) thrombolytic effect (34.72 ± 1.74%) contrasted with standard streptokinase (67 ± 1.56%). The extract at doses of 200 and 400 mg/kg produced inhibition of 32.58% and 46.63% in acetic acid-induced pain and 45.88 and 61.18% in formalin-induced pain. The sedative and hypnotic activities on the central nervous system of the methanol extract of F. cunia (MEFC) leaves were evaluated. The extract delivered critical sedative impact at the doses of 200 and 400 mg/kg (by oral route) treated with reference to the substance diazepam, and the hypnotic impact was also observed in the case of mice. MEFC at its maximum dose (400 mg/kg) significantly (p < 0.01) increased the time spent in the open arms of the EPM. In the hole board test, there was a dose-dependent (at 200 and 400 mg/kg) and a significant (p < 0.05 and p < 0.01) increase in the number of head pokes in comparison to control.

Conclusions
The results of the present study gave a helpful baseline in progression for the possible use of MEFC as a cytotoxic, thrombolytic, analgesic, sedative-hypnotic and anxiolytic drug.
Glial pathology in neuropsychiatric disorders: a brief review
Authors: Mayegowda Shilpa Borehalli , Thomas Christofer 
Published: July 2019

Abstract
Neurons have been considered the major functional entities of the nervous system that are responsible for most of the functions even though glial cells largely outnumber them. However, recent reports have proved that glial cells do not function just like glue in the nervous system but also substantially affect neuronal function and activities, and are significantly involved in the underlying pathobiology of various psychiatric disorders. Dysfunctional astrocytes and degeneration of glial cells are postulated to be critical factors contributing to the aggravation of depressive-like symptoms in humans, which was proved using animal models. Alteration in glial cell function predominantly targets three main brain regions – the prefrontal cortex, limbic areas including the hippocampus, and the amygdala, which have been extensively studied by various researchers across the globe. These studies have postulated that failure in adopting to the changing neurophysiology due to stress will lead to regressive plasticity in the hippocampus and prefrontal cortex, but to progressive plasticity in the amygdala. In this present review, an effort has been made to understand the different alterations in chronic stress models in correlation with clinical conditions, providing evidence on the defective maintenance of glial function and its potential role in the precipitation of neuropsychiatric disorders.
Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model
Authors: Molehin Olorunfemi R. , Adeyanju Anne A. , Adefegha Stephen A. , Oyeyemi Ajibade O. , Idowu Kehinde A. 
Published: July 2019

Abstract

Background
Doxorubicin (DOX) induces toxicity in many tissues/organs, including the heart, kidney and so on. This study was designed to evaluate the modulatory effects of protocatechuic acid (PCA) against DOX-induced nephrotoxicity in rats. Animals were randomly grouped into five groups.

Methods
Group 1 served as the normal control (CTR). A single dose of DOX at 20 mg/kg was administered intraperitoneally (i.p.) to animals in Group 2. Groups 3 and 4 were pretreated with PCA for 5 days (doses of 10 and 20 mg/kg body weight, respectively) after which DOX was injected (PCA-10 + DOX and PCA-20 + DOX). Group 5 received PCA only at a dose of 20 mg/kg body weight (PCA-20).

Results
The results revealed significant elevations (p < 0.05) in malondialdehyde content, expressions of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX2) in the kidney. Likewise, increased serum levels of creatinine and urea of DOX group were observed. A significant decrease (p < 0.05) in glutathione (GSH) level and antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione s- transferase (GST) activities in the kidney were observed compared with the control. Pretreatment with PCA (10 and 20 mg/kg, p.o.) for 5 days prior to the i.p. injection of DOX reduced MDA levels, modulated iNOS and COX2 activities and improved kidney function markers as well as oxidative stress parameters. Findings from the histopathology studies confirms the protective effects of PCA on DOX-induced damage on the kidney cells.

Conclusions
This study has demonstrated the anti-inflammatory and antioxidative properties of PCA, which could be part of its possible protective mechanisms against nephrotoxicity induced by DOX.
Directional Beam Based LED Deployment for a Short Range Indoor LED Light Communication System
Authors: Sharma Ram , Charan Kumari A. , Aggarwal Mona , Ahuja Swaran 
Published: July 2019

Abstract
There is now an increasing awareness about the possibility of health hazards due to excessive electromagnetic radiations around us within the indoor environment. Hence, the alternative communication technologies such as indoor mobile communication system based on LED lighting are gaining more attention in the present scenario. The dual use of LEDs i. e. for illumination as well as for setting up of an indoor communication network infrastructure simultaneously makes it an attractive preposition. The LED lighting based communication system is qualified to be part of green technology networks. This paper investigates the optimal LED placement strategy for such a system to optimize the overall communication system parameters including the transmit power optimization. It is observed that the overall optimization of LEDs improve the signal to noise ratio and also a significant reduction in root mean square delay at lower semi-angle values besides improving the mobile coverage area.
Radio over Fibre Transport of Alamouti-coded MIMO Signals with Self-Recovery Capability
Authors: Kaur Jaswinder , Sharma Vishal 
Published: July 2019

Abstract
Radio over Fibre (RoF) transport of high-speed wireless data provides a comprehensive solution for the forthcoming highly-reliable and spectral-efficient wireless systems. MIMO is one of the most widely used wireless technologies to increase the system reliability and capacity without any increased demand of power/bandwidth. However, the inherent non-linearities of RoF link and the multipath fading of the wireless channel can degrade the overall performance of the wireless system. In this work, authors demonstrate RoF transport of adaptively modulated MIMO signals and report the improvement in spectral efficiency under the impact of RoF link non-linearity. The transmitter of the proposed RoF based wireless system selects the appropriate modulation scheme with the assumption of perfect channel state information to achieve the acceptable BER at the subscriber end. The spectral efficiency improvement by this self-recovering MIMO-RoF system is evaluated by incorporating orthogonal Space-Time Block Code with 2 × 2 antenna configuration over the frequency-selective Rayleigh fading channel.
DP-QPSK Technique for Ultra-high Bit-rate DWDM FSO System
Authors: Pradhan Subhrajit , Patnaik Bijayananda , Panigrahy Rashmita Kumari 
Published: July 2019

Abstract
This paper proposes an ultra-high capacity free space optical communication (FSO) system, employing optical dual polarization quadrature phase shift keying (DP-QPSK) modulation format. It is a 16-channel dense wavelength division multiplexing (DWDM) system with 120 Gbps/channel bit rate. The FSO system is analyzed with three optical advanced modulation schemes; such as 4-quadrature amplitude modulation (4-QAM), quadrature phase shift keying (QPSK) and DP-QPSK. The main focus of the projected system is to improve the FSO setup performance in terms of eye diagram, bit error rate (BER), high received power and Q-factor. The center channel wavelength used for the proposed system is 1550 nm. In the present wireless communication world, the proposed system will be highly helpful as an ultrahigh capacity wireless system.
Charge transfer and electromagnetic enhancement processes revealed in the SERS and TERS of a CoPc thin film
Authors: Chen Yu-Ting , Pan Lin , Horneber Anke , van den Berg Marius , Miao Peng , Xu Ping , Adam Pierre-Michel , Meixner Alfred J. , Zhang Dai 
Published: July 2019

Abstract
Phthalocyanines are frequently used as probing molecules in the field of single-molecule surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS). In this work, we systematically compare the SERS and TERS spectra from a thin cobalt phthalocyanine (CoPc) film that is deposited on a Au film. The contributions from electromagnetic (EM), resonance, and charge-transfer enhancements are discussed. Radially and azimuthally polarized vector beams are used to investigate the influences of molecular orientation and the localized surface plasmon resonance (SPR). Furthermore, two different excitation wavelengths (636 and 532 nm) are used to study the resonant excitation effect as well as the involvement of the charge-transfer processes between CoPc and the Au substrate. It is shown that the Raman peaks of CoPc are mostly enhanced by 636 nm excitation through a combination of resonant excitation, high EM enhancement, and chemical enhancement via charge transfer from the metal to the molecule. At 532 nm excitation, however, the SERS and TERS spectra are dominated by photoluminescence, which originates from a photo-induced charge-transfer process from the optically excited molecule to the metal. The contributions of the different enhancement mechanisms explain the optical contrasts seen in the TERS images of Au nanodisks covered by the CoPc film. The insight achieved in this work will help to understand the optical contrast in sub- or single-molecule TERS imaging and apply SERS or TERS in the field of photocatalysis.