bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extending property on EC-Fully Submodules
Authors: YAŞAR Ramazan , TERCAN Adnan 
Published: July 2018

There
are several generalizations of -modules
in literature. One of the generalization is based on fully invariant
submodules. Recall that a
module is called -extending
if every fully invariant submodule is essential in a direct summand. We call a module
-extending
if every fully invariant submodule which contains essentially a cyclic
submodule is essential in a direct summand. Initially we obtain basic
properties in the general module setting. For example, a direct sum of -extending
modules is -extending.
Again, like the -extending
property, the -extending
property is shown to carry over to matrix rings.
REGULARITIES OF FORMATION AND DEGRADATION OF THE MICROSTRUCTURE AND PROPERTIES OF NEW ULTRAFINE-GRAINED LOW-MODULUS Ti–Nb–Mo–Zr ALLOYS
Authors: Kolobov Yu. R. , Golosova O. A. , Manokhin S. S. 
Published: July 2018

Regularities of the formation of ultrafine-grained (UFG) and submicrocrystalline (SMC) structures in new nickel-free low-modulus Ti–Nb–Mo–Zr titanium β alloys under the action of plastic deformation were studied. Temperature-time ranges of the development of dynamic recrystallization processes under the simultaneous action of temperature and plastic deformation were determined. The recrystallization diagram of II type of the Ti–28Nb–8Mo–12Zr alloy was constructed and analyzed. It was shown using scanning electron microscopy and electron backscatter diffraction method that the UFG structure with an average grain size of no more than 7 μm and high fraction of high-angle grain boundaries is formed in the investigated alloys as a result of longitudinal rolling followed by annealing for quenching. It was found that the formation of the UFG structure leads to a significant increase in the strength and plastic characteristics of these alloys. The regularities of the formation of UFG and SMC structures in the titanium β alloys Ti–28Nb–8Mo–12Zr and VT30 widely used in industry under the action of plastic deformation by the helical rolling method were studied. It was shown that the helical rolling of the VT30 alloy leads to the formation of the homogeneous UFG state as opposite to the developed Ti–28Nb–8Mo–12Zr β alloy where this method causes structure softening with micropores and microcracks formed in the central region. It is possible to form a nanostructured state with an average grain size of about 100 nm in Ti–Nb–Mo–Zr titanium β alloys using high-pressure torsion method.
Characteristics of electrophysiological activity of the cerebral cortex in children with arthrogryposis
Authors: Blagoveschenskiy E. D. , Agranovich O. E. , Kononova E. L. , Baindurashvili A. G. , Nazarova M. A. , Shestokova A. N. , Gabbasova E. L. , Nikulin V. V. 
Published: July 2018

Background. Arthrogryposis is one of the most severe congenital abnormalities of the musculoskeletal system characterized by 2 or more contractures of the large joints, muscle and anterior grey column pathology. One of the main problems making selfcare limited or impossible for the patients is an absence of the active movements in the joints of the upper extremities which can be restored through autologous transplantation from the various donor areas. Processes of the rehabilitation after these operations are associated with neuronal remodeling in the central nervous system both in the spinal cord and the brain, in the cortial regions in particular.The objective is to evaluate possible reflection of arthrogryposis in the amplitude and neurodynamical characteristics of the electroencephalogram (EEG) in children.Materials and methods. Electrophysiological characteristics of the cerebral cortex in children with arthrogryposis and healthy children of the same age were examined. Such EEG characteristics as power and long-range temporal correlations (evaluation of the neuronal activity dynamics) in ranges of 4–8, 8–12, and 12–16 Hz were measured. The results were evaluated in accordance with clinical scales.Results. Data analysis has shown that children with arthrogryposis have significantly decreased EEG power in all of the studied ranges compared to healthy children. Additionally, a significant correlation between EEG power and the level of restoration of motor functions in the upper extremities after autologous transplantation of various muscle groups in the position of the biceps was observed. The obtained results reflect correlation between the electrophysiological parameters of the cerebral cortex and processes associated with arthrogryposis pathology. However, neurodynamical parameters in children with arthrogryposis are similar to those in healthy children. The results allow to state that arthrogryposis is reflected through decreased electrical activity of the cerebral cortex in 4–16 Hz range with preservation of neurodynamic characteristics typical for disease-free children.Conclusion. In this study, a significant difference in EEG power in 4–8, 8–12, and 12–16 Hz ranges between children with arthrogryposis and healthy children was demonstrated. However, there was no difference in such an important neurodynamical characteristic as longrange temporal correlations. It is possible that decreased amplitude of EEG rhythms in children with arthrogryposis is caused by their lower motor activity in general.
Evaluation of methylation status of the 5’-promoter region of C9orf72 gene in Russian patients with neurodegenerative diseases
Authors: Shpilyukova Yu. A. , Fedotova E. Yu. , Pogoda T. V. , Abramycheva N. Yu. , Vetchinova A. S. , Zakharova M. N. , Illarioshkin S. N. 
Published: July 2018

Background. Hexanucleotide repeat expansion in the C9orf72 gene is the most significant cause of a large number of neurodegenerative diseases: frontotemporal degeneration (FTD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), etc. Several studies have shown the relationship with the neurodegenerative process for full (>40 GGGGCC copies) and intermediate (13–20) repeats expansion. Methylation of the C9orf72 gene can play an important role in the pathogenesis of FTD and ALS, but the mechanism has not been sufficiently studied.The objective is to investigate the status of methylation of the 5’-promotor region of the C9orf72 gene in patients with neurodegenerative disorders having full or intermediate expansion of GGGGCC-repeats.Materials and methods. We investigated the methylation status of the 5’-promoter region of full C9orf72 expansions in FTD/ALS patients (n = 12), of intermediate expansions in Parkinson’s disease patients (n = 8) and of non-expanded alleles in healthy controls (n = 8). Methylation status was determined via sequencing of amplified fragments of bisulfite-converted DNA.Results. We identified two cases (sibling) with the hypermethylation of the 5’-promoter region in the full C9orf72 expansions group. Patient A. (65 years old, male) had an atypical ALS presentation: an onset with head tremor, a long duration of ALS symptoms (9 years at this time), and cognitive impairments with a temporal lobes atrophy. The patient’s sister had a similar clinical phenotype. There were no cases of the promoter hypermethylation in the intermediate and control groups.Conclusion. This is the first data on the 5’-promoter region C9orf72 gene methylation in Russian population. The frequency of the promoter methylation in this group was 9.1 % that consistent with previous studies in other populations. Atypical clinical presentation may indicate a modifying effect of methylation in this area on the ALS phenotype.
Functional disorders of maxillofacial region in children with cerebral paralysis
Authors: Danilova M. A. , Bronnikov V. A. , Zalazaeva E. A. 
Published: July 2018

Aim. To reveal the peculiar features of functional disorders in maxillofacial region among children with cerebral paralysis.
Materials and methods. While carrying out complex neurological, stomatological and logopedic examination of 120 patients (age 3 to15 years) with the above mentioned diagnosis, the following was assessed: the course of speech development (first words, phrases), state of general, fine and speech motor activity, speech sounding, status of speech apparatus.
Results. The data on frequency and structure of functional maxillofacial disorders in children with cerebral paralysis were obtained. Thus, dysfunction of swallowing was detected in 32,5 % of cases. In 53,33 % of cases from the total number of the examined patients, there was revealed the impaired chewing function in the form of slow chewing process, which occurred in 100,0 % of cases among children with double hemiplegia. Impaired speech development in the form of pseudobulbar dysarthria (spasticoparetic, spasticorigid) and anarthria was diagnosed in 82 (68,33 %) persons, speech development corresponded to age in 38 (31,67 %) children.
Conclusions. The obtained data on peculiar features of functional maxillofacial disorders, observed among children with different clinical variants of spastic cerebral paralysis forms, should be used in practical health care for planning treatment-and-prophylactic measures at rehabilitation centres.
On problems and algorithm of prescribing combined medicinal preparations, containing small quantities of narcotic drugs and psychotropic substances
Authors: Porseva N. Yu. , Soloninina A. V. , Rostova N. B. 
Published: July 2018

Aim. To analyze the regulating documents and work out the algorithm of prescribing combined medicinal preparations, containing small quantities of narcotic drugs, psychotropic substances, their precursors and other pharmacological active substances.
Materials and methods. The normative documents, regulating the order of prescribing and selling combined medicinal preparations, containing narcotic drugs, psychotropic substances and their precursors were analyzed.
Results. Some normative documents to regulate the order of prescribing combined medicinal preparations, containing narcotic drugs and psychotropic substances, present problems. To simplify the procedure of prescribing such medicinal preparations, there was suggested an algorithm, explaining: the choice of prescription form; conditions of prescribing combined medicinal preparation by trade name; terms of prescription validity and possibilities of their prolongation; regulated possibilities for exceeding norms of prescribing medicinal preparations and order of their registration.
Conclusions. The suggested algorithm of the order of prescription will promote observation of requirements of the existing normative acts.
Grounding of using treatment-and-rehabilitation complex for patients with occupational lumbosacral radiculopathy
Authors: Shaikhlislamova E. R. , Karimova L. K. , Gallyamova S. A. , Urmantseva F. A. , Iskhakova D. R. , Alakaeva R. A. 
Published: July 2018

Aim. To ground and estimate the efficiency of using nonmedicamentous methods of treatment in patients with occupational radiculopathy of lumbosacral level.
Materials and methods. Sixty seven patients, diagnosed occupational lumbosacral radiculopathy, were examined; patients’ neurological status, manifestation of pain syndrome by 10-score visual analog scale and neuromuscular state by stimulation electroneuromyography data prior to and after treatment were assessed.
Results. Treatment-and-rehabilitation complex included magnetic-laser therapy, acupuncture, combined with curative gymnastics. By the completion of treatment, positive dynamics regarding nearly all neurological states, including reduced manifestation of painful sensations, increased volume of active movements in the lumbar spine, decreased hyperesthesia rate and hypoesthesia intensity in the zone of injured roots, decreased occurrence of Lasegue test was observed. Dynamics of electroneuromyographic parameters was expressed by improved conduction of nerve impulses through the peripheral low extremity nerves and roots L4, L5, S1 of cerebrospinal nerves.
Conclusions. Application of the offered complex provided positive effect by the end of treatment in 82.3 % of cases.
Potential Predictors for HPV Vaccination Completion Rates
Authors: Sachdev Arushi , Sekhon Kerman 
Published: July 2018

Background Human papillomavirus (HPV) is the most common sexually transmitted pathogen; its ease in transmission significantly contributes to its prevalence within the population. While most HPV infections are asymptomatic, a subset of infections cause genital warts, cervical cancer and various anogenital cancers. Accordingly, the vaccine Gardasil has been designed to prevent HPV infection and its associated sequelae. While Gardasil is effective against over 75% of cervical cancers, recent studies have demonstrated its limited adoption. In 2010, only 49% of females between the ages of 13-17 had received at least one dose. Moreover, Gardasil is a three-dose vaccine, and consequently, female patients that initiate the vaccination series often do not complete it in its entirety. Methods Data obtained from researchers at the Johns Hopkins Medical Institutions (JHMI) was used to determine which socioeconomic factors influence a female’s likelihood of vaccination completion. The dataset consisted of female patients between the ages of 11-26 that had received at least one of the Gardasil vaccine doses from a JHMI clinic in Baltimore, USA, between the years 2006 and 2008. First, three logistic regression models were run with vaccination regimen completion, one shot completed and two shots completed as the dependent variables. Then, three LASSO logistic regression models were run to find relationships that were not influenced by model overfitting. The two regression methods were compared to determine if different results could be achieved. Results For the logistic regression, findings revealed that black females (P = 0.006881), females between the ages of 18-26 (P = 0.000483), and females that visited urban clinics (P = 0.004582) are at an increased risk of incomplete vaccinations. In contrast, females that were treated by obstetrician-gynecologists (P = 0.006269) had increased compliance with the Gardasil vaccination regimen compared to women that visited other healthcare professionals. For the LASSO logistic regression, the model that penalized the most for overfitting showed that black females have a higher likelihood of only receiving one shot. Conclusions Due to the retrospective nature of the data, no causation can be established. However, these correlations shed light on what female populations should be studied further and potentially targeted to improve Gardasil vaccination completion rates. Moreover, the differences in vaccination completion rates can, in turn, aggravate the existing disparities in cervical cancer risk among females.
GIDA SEKTÖRÜNDE YENİ ÜRÜN GELİŞTİRME: KONYA’DA BİSKÜVİ, ÇİKOLATALI VE ŞEKERLİ MAMULLER ALT SEKTÖRÜ ÜZERİNE BİR UYGULAMA
Authors: ÖZTÜRK Derya , ONURLUBAŞ Ebru 
Published: July 2018

Günümüzde
imalat işletmeleri, teknolojik yenilikler, ürün ömrünün kısalması ve müşteri
beklentilerindeki hızlı değişim gibi sorunlarla karşı karşıyadır. Rekabet
ortamında hızlı değişimin yaşandığı bu durum, işletmelerin pazardaki
yenilikleri yakından takip etme zorunluluklarını ortaya çıkarmıştır. Bu
bağlamda çalışmanın amacı, gıda sektöründe faaliyet gösteren öncü bir firmanın X markasının yeni
ürün geliştirme sürecinin incelenmesidir. Bu amaçla çalışmada, Konya’da bisküvi, çikolatalı ve şekerli mamuller
üreten bir firmanın ürün geliştirme sürecine katkı sağlayan 110 firma
personeline yüz-yüze anket uygulanmıştır. Elde edilen verilerden frekans
analizi ile durum tespiti yapılırken, yeni ürün fikri oluşturmada etkili olan
faktörler ve yeni ürün bulma teknikleri demografik değişkenlere göre ki-kare
testi ile karşılaştırılmıştır. Araştırma sonuçlarına göre, katılımcıların %50,9’u yeni ürün fikri oluşturmada
hedef pazarı dikkate aldığını ifade ederken, yeni ürün fikri oluşturmada etkili
olan faktörlerin personelin çalışma yıllarına göre değişim gösterdiği
belirlenmiştir. Katılımcıların %66,4’ü müşteri analizini yeni ürün bulma
tekniği olarak gösterirken, yeni ürün bulmada kullanılan tekniklerin ise firmada
çalışma yıllarına ve personelin işletmedeki pozisyonuna göre değişim gösterdiği
bulunmuştur.
Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score
Authors: Sane Rohit , Sugwekar Varada , Nadapude Aarti , Hande Archana , Depe Gayatri , Mandole Rahul 
Published: July 2018

Background: Number of people dying from IHD has increased from 0.61 million in 1990 to 1.13 million in 2010, which is a disturbing fact. According to report by World Health Organization, India would be spending a whopping 237 billion US dollars, owing to direct spending on health care and indirectly due to loss of productivity due to IHD. Ischemia Reversal Program (IRP) is a combination of Panchakarma and allied therapy. This study was conducted to evaluate the effect of IRP on VO2max, Duke’s treadmill score, systolic blood pressure (SBP), diastolic blood pressure (DBP), and dependency on conventional therapy in IHD patients.Methods: This observational study was conducted in January 2017, wherein the data of IHD patients (inducible ischemia on stress testing) who attended out-patient departments (OPDs) at Madhavbaug clinics in Maharashtra, India were identified. Data of patients who were administered IRP (60-75 minutes) with minimum 7 sittings over 90 days (±15 days) were considered. Variables were compared between day 1 and day 90 of the IRP.Results: Out of 38 enrolled patients, 25 were males while 13 females. There was significant improvement in Duke’s score with subjects at moderate (50%) and high (31.6%) risk at baseline were significantly decreased to low (52.6%) and moderate (47.4%) after the 90th day of therapy. IRP also showed significant improvement in VO2max by 9.11 (from 20.29±6.72 to 29.40±6.71; p<0.001), SBP by 5.78 (from 128.78±17.40 to 123±12.23, p<0.03), DBP by 4.76 (from 80.53±8.10 to 75.76±6.85, p<0.005). Dependency on concomitant medicines was reduced.Conclusions: IRP was effective in IHD; it had dual benefits, i.e. anti-ischemic effect, as well as reducing the dependency on allopathic medicines.
Frequency of gross total resection in intra-axial brain tumors with help of neuronavigation
Authors: Irshad Muhammad , Manzoor Ch Ali , Aamir Muhammad 
Published: July 2018

Background: Neuronavigation has become a ubiquitous tool in the surgical management of brain tumors. Neuronavigation is most useful as an adjunct to other brain-mapping techniques such as awake mapping and electrocorticography in the resection of lesions within eloquent motor and language areas. Neuronavigation is also commonly used in skull base tumors, especially for planning an operative trajectory in regions containing vital neurovascular structures and may be used for cerebrovascular surgery. The current study was planned to determine the frequency of gross total resection in intra-axial brain tumors with the help of neuronavigation.Methods: This cross-sectional study was carried out in the Department of Neurosurgery, Nishtar Medical College and Hospital, Multan, from September 2014 to March 2015. After approval from institutional ethical committee, seventy-seven patients fulfilling the inclusion criteria were selected from the patient admitted in the Neurosurgical Department through the Out-Patient Department and patients referred from other departments. After thorough counseling with the patient and his/her relatives, informed consent for procedure was taken.Results: Total 78 patients were included in the study. Out of these 78 (100%), 41 (52.6%) were male and 37 (47.4%) were female. As concern to the outcome variable (gross total resection), out of 78 (100%), in 61 (78.2%) patients gross total resection was present. On cross tabulation it was further clarified that in male patients’ gross total resection present in 32 patients and absent in 9 patients. Similarly, in female patients gross total resection present in 29 patients and absent in 8 patients. P value was 0.747.Conclusions: Conclusion of present study is that neuronavigation is a useful technique in for better gross total resection of intra axial brain tumors.
Kyasanur forest disease: a rare viral hemorrhagic disease in India
Authors: Dhaka Rohit , Verma Ramesh , Kumar Raj , Dhankar Mukesh , Bhalla Kapil , Agrawal Ginni 
Published: July 2018

Kyasanur forest disease (KFD) is a rare hemorrhagic disease in India and isolated in monkeys in the Kyasanur Forest of the Shimoga district, Karnataka State in India in 1957. KFD is a zoonotic disease and endemic in southern part of India. KFD Virus commonly infects the black faced langur monkey (Semnopithecus entellus). No evidence for human-to-human transmission. Large domestic animals (cows, goats, sheep) that become infected are thought be important only for sustaining tick population. When monkeys come in contact with the infected ticks, they get infected, amplify and disseminate the infection creating hot spots of infection. The people who pass through the forest are bitten by the infected nymphs of H. spinigera, which are highly anthropophilic. Local villagers staying in and around the forest area frequently visit the forest for collection of fire woods, grass and get infected through tick bites. The incubation period is 3-8 days and patients presented with following symptoms like chills, frontal headache, bodyache, and high fever for 5-12 days. There were 466 human cases during initial outbreak and 181 more the following year and has caused epidemic outbreaks of haemorrhagic fever affecting 400 to 1000 people per year since then, with mortality rate of 4 and 15%. In 2012, 9 persons were found positive for KFD, in Theerthahlli taluk of district Karnataka. There is no specific treatment for KFD but a timely supportive therapy reduces the mortality in human being.
Ayushman Bharat Yojana: a memorable health initiative for Indians
Authors: Dhaka Rohit , Verma Ramesh , Agrawal Ginni , Kumar Gopal 
Published: July 2018

India in a state of epidemiological health transition i.e shifting from communicable to non-communicable diseases. The annually 3.2% Indians falling below the poverty line and three forth Indians spending their entire income on health care and purchasing drugs. The government of India announced a Ayushman Bharat Yojana- National Health Protection Scheme (AB-NHPM) in the year 2018. The aim of this programme is to providing a service to create a healthy, capable and content new India and two goals are to creating a network of health and wellness infrastructure across the nation to deliver comprehensive primary healthcare services and to provide health insurance cover to at least 40% of India's population which is deprived of secondary and tertiary care services. This Yojana will be implemented through Health and Wellness Centres that are to be developed in the primary health centre or sub-centre in the village and that will provide preventive, promotive, and curative care for non-communicable diseases, dental, mental, geriatric care, palliative care, etc. These centres would be equipped with basic medical tests for hypertension, diabetic and cancer and they are connected to the district hospital for advanced tele-medical consultations. The government has aims to set up 1,50,000 health and wellness centres across the country by the year 2022.