bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking Through the Lens of a Family Planner to Prioritize Reproductive Health Among Women With Cancer
Authors: Madrigal Jessica M. , Atluri Mokshasree , Radeke Erika K. , Patel Ashlesha 
Published: February 2019

PURPOSE: Prioritization of cancer treatment initiation in women of reproductive age may underscore potential implications on reproductive health. This study describes a family planning quotient (FPQ) and reproductive life index (RepLI) tool designed to help providers to discuss effectively reproductive health with women with cancer. METHODS: We tailored the FPQ/RepLI tool for patients with cancer after development in the family planning setting and piloted it with 36 oncology patients referred to our family planning clinic. Each patient completed the FPQ/RepLI with a health educator or medical student and then met with a physician to create a reproductive life plan. A subsample evaluated the tool by rating satisfaction using a Likert scale. Summary statistics were calculated overall and by childbearing status. RESULTS: Of the 36 women, 22 did not desire additional children and received contraception. One third (n = 14) had not completed childbearing, four of whom continued with fertility preservation counseling. Women who desired childbearing were less likely to already have children ( P = .02), and more than one half were using long-term contraception. All agreed that the FPQ/RepLI helped them to talk to their provider about their reproductive goals. Only 44.4% agreed that their oncologist knew how many children they desired, and 88.9% found the tool helpful and would use it for future tracking of their reproductive goals. CONCLUSION: The FPQ/RepLI is useful for assessing the reproductive health of young women with a new cancer diagnosis, understanding desires of future childbearing, and providing effective contraception. We recommend the incorporation of this tool into practice to better understand patients’ reproductive needs.
Oral mucositis in patients undergoing radiotherapy for head and neck cancer: An observational cross-sectional study
Authors: Al-Qalamji Marwa Ayad Nouri , Al-Rawaq Khudair Jassim , Al-Nuaimi Dalya Saad Abbood , Mahmood Noori Ali Ghalib 
Published: February 2019

Background:Radiotherapy (RT) is indispensable in the treatment of head and neck cancer (HNC). Oral mucositis (OM) is a complication in HNC patients undergoing RT. This study aimed to identify the incidence, distribution of OM, and its effect on treatment breaks in a section of HNC in patients in Iraq.Methods:This is an observational, descriptive cross-sectional study. In total, 50 patients with primary HNC, treated with external beam RT, from 30th April to 10th September 2017 at Baghdad Radiation Oncology and Nuclear Medicine Center were included in the study. Cases of OM were graded according to the World Health Organization scale.Results:80% of patients were below 65 years, and the male/female ratio was 2.6:1. Tumor sub-sites were nasopharynx (36%), larynx (22%), parotid (14%) and tongue (12%). 74% were smokers during or before starting RT. 86% were in stages III or IV. Incidence of OM was 72%; 16% grade I, 40% grade II, and 16% grade III. OM occurred in 93% females and 64% males, and 79% received concurrent regimens.Conclusions:OM occurred in HNC treated by RT, more in females, who received chemotherapy plus RT, and those with tumors of the oral cavity and nasopharynx. OM-related unplanned breaks may interrupt treatment schedule. HNC imposes a double burden in Iraq as it attacks a productive age group, and the vast majority of the patients included in this study were diagnosed in advanced stages.
Stage 1 Registered Report: The relationship between handedness and language ability in children
Authors: Pritchard Verena E. , Malone Stephanie A. , Burgoyne Kelly , Heron-Delaney Michelle , Bishop Dorothy V.M. , Hulme Charles 
Published: February 2019

Weak or inconsistent hand preference may be a risk factor for developmental language delay. This study will test the extent to which variations in language skills are associated with the strength of hand preference. Data are drawn from a large sample (n = 569) of 6- to 7-year-old children unselected for ability, assessed at two time points, 6 months apart. Hand preference is assessed using the Quantitative Hand Preference task (QHP) and five uni-manual motor tasks. Language skills (expressive and receptive vocabulary, receptive grammar, and morphological awareness) are assessed with standardized measures. If weak cerebral lateralisation (as assessed by the QHP task) is a risk factor for language difficulties, it should be possible to detect such effects in the large representative sample of children examined here.
Homograft Aortic Root Replacement with Saphenous Vein Graft Hemi-Cabrol for Prosthetic Aortic Valve Endocarditis
Authors: Dimarakis Ioannis , Wooldridge Wilfred , Kadir Isaac 
Published: February 2019

AbstractA 44-year-old female presented with prosthetic valve endocarditis with periannular abscess involving the left coronary ostium. We describe cryopreserved aortic homograft root replacement with hemi-Cabrol reimplantation of the left coronary ostium using the long saphenous vein.
Maximum Diameter of Native Abdominal Aortic
Aneurysm Measured by Angio-Computed
Tomography
Authors: Mora Caroline , Marcus Claude , Barbe Coralie , Ecarnot Fiona , Long Anne 
Published: February 2019

Background:
Computed tomography angiography (CTA) is the reference technique for the measurement of native maximum abdominal aortic aneurysm (AAA) diameter when surgery is being considered. However, there is a wide choice available for the methodology of maximum AAA diameter measurement on CTA, and to date, no consensus has been reached on which method is best. We analyzed clinical decisions based on these various measures of native maximum AAA diameter with CTA, then analyzed their reproducibility and identified the method of measurement yielding the highest agreement in terms of patient management.

Materials and Methods:
Three sets of measures in 46 native AAA were obtained, double-blind by three radiologists (J, S, V) on orthogonal planes, curved multiplanar reconstructions, and semi-automated-software, based on the AAA-lumen centerline. From each set, the clinical decision was recorded as follows: "Follow-up" (if all diameters <50 mm), "ambiguous" (if at least one diameter <50 mm AND at least one ≥50 mm) or "Surgery " (if all diameters ≥50 mm). Intra- and interobserver agreements in clinical decisions were compared using the weighted Kappa coefficient.

Results:
Clinical decisions varied according to the measurement sets used by each observer, and according to intra and interobserver (lecture#1) reproducibility. Based on the first reading of each observer, the number of AAA proposed for surgery ranged from 11 to 24 for J, 5 to 20 for S, and 15 to 23 for V. The rate of AAAs classified as "ambiguous" varied from 11% (5/46) to 37% (17/46).The semi-automated method yielded very good intraand interobserver agreements in clinical decisions in all comparisons (Kappa range 0.83–1.00).

Conclusion:
The semi-automated method seems to be appropriate for native AAA maximum diameter measurement on CTA. In the absence of AAA outer-wallbased software more robust for complex AAA, clinical decisions might best be made with diameter values obtained using this technique.
An L-Shaped Incision for an Extensive Thoracic Aortic Aneurysm and Coronary Artery Bypass Using the Left Internal Thoracic Artery
Authors: Abe Tomonobu , Suenaga Hiroto , Oshima Hideki , Araki Yoshimori , Mutsuga Masato , Fujimoto Kazuro , Usui Akihiko 
Published: February 2019

AbstractAn L-shaped incision combining an upper half mid-sternotomy and a left antero-lateral thoracotomy at the fourth intercostal space has been proposed by several authors for extensive aneurysms involving the aortic arch and the proximal thoracic descending aorta. This approach usually requires the division of the left internal thoracic artery at its mid position, thus making it unusable for coronary artery bypass. We herein report a modified surgical approach for simultaneous extensive arch and proximal thoracic descending aorta replacement and coronary artery bypass using the left internal thoracic artery combining a left antero-lateral thoracotomy at the sixth intercostal space and upper mid-sternotomy. The visualization of the whole diseased aorta down to the level below the hilum of the left lung was good, and the integrity of the left internal thoracic artery graft was preserved by early heparin administration before sternotomy.
Autoimmunity in the Abdominal Aortic Aneurysm and its Association with Smoking
Authors: Tilson M. David 
Published: February 2019

AbstractSmoking increases the risk of abdominal aortic aneurysm (AAA) in both humans and mice, although the underlying mechanisms are not completely understood. An adventitial aortic antigen, AAAP-40, has been partially sequenced. It has motifs with similarities to all three fibrinogen chains and appears to be connected in evolution to a large family of proteins called fibrinogen-related proteins. Fibrinogen may undergo non-enzymatic nitration, which may result from exposure to nitric oxide in cigarette smoke. Nitration of proteins renders them more immunogenic. It has recently been reported that anti-fibrinogen antibody promotes AAA development in mice. Also, anti-fibrinogen antibodies are present in patients with AAA. These matters are reviewed in the overall context of autoimmunity in AAA. The evidence suggests that smoking amplifies an auto-immune reaction that is critical to the pathogenesis of AAA.
Pre-Service Teachers’ Problem Solving Skills and Curiosity Levels
Authors: Aldan-Karademir Cigdem 
Published: February 2019

<p style="text-align:justify">The aim of the study is to examine the pre-service teachers’ problem solving skills and curiosity levels according to different variables and to determine whether there is a relationship between them. The research was designed as a descriptive study in the survey model. The sample of the study consists of 1st and 4th grade pre-service teachers in the departments of German, Science, English, Mathematics, Music, Pre-school, Painting, English, Mathematics, Turkish Language Teaching at a university in Turkey. “Curiosity Scale” adapted into Turkish by Demirel and Diker Coskun, “Problem Solving Inventory” adapted into Turkish by Sahin, Sahin and Heppner and “Personal Information Form” prepared by the researcher were used as data collection tools. In the analysis of the data obtained, SPSS-Windows 22.00 package program was used and descriptive statistics and parametric tests were applied in accordance with the sub-problems of the study. In addition, a correlation analysis was conducted to determine whether there was a relationship between pre-service teachers’ problem solving skills and curiosity levels. Based on the findings, suggestions about the problem solving skills and curiosity levels of the prospective teachers were presented.</p>
Diversidade e Educação: Crianças brasileiras e práticas religiosas no cotidiano das escolas públicas japonesas
Authors: Dias Nilta 
Published: February 2019

Resumen
Este artículo analiza casos relacionados con la diversidad cultural y religiosa de niños brasileños que estudian en escuelas públicas japonesas. Partiendo de la experiencia de la autora como educadora en escuelas japonesas y brasileñas en Japón por más de quince años, revela cómo las creencias y prácticas religiosas afectan las vidas de los niños inmigrantes cuando interactúan en esas escuelas. Los aspectos culturales y las relaciones humanas se entrelazan para desafiar y ser desafiados por las creencias y prácticas religiosas de los niños. La autora investiga el contexto complejo y diverso de las prácticas religiosas que dan forma a la dieta, el cuerpo y las prácticas diarias de niños cristianos y no-cristianos.

Palabras clave: Migraciones transnacionales, Nipo-brasileños, Aspectos culturales, Escuela pública japonesa, Cotidiano escolar.
The Misclassification of Ambivalence in Pregnancy Intentions: A Mixed‐Methods Analysis
Authors: Gómez Anu Manchikanti , Arteaga Stephanie , Villaseñor Elodia , Arcara Jennet , Freihart Bridget 
Published: February 2019

AbstractCONTEXTResearchers have developed various measures of pregnancy ambivalence in an effort to capture the nuance overlooked by conventional, binary measures of pregnancy intention. However, the conceptualization and operationalization of the concept of ambivalence vary widely and may miss the complexity inherent in pregnancy intentions, particularly for young people, among whom unintended pregnancy rates are highest.METHODSTo investigate the utility and accuracy of current measures of pregnancy ambivalence, a mixed‐methods study was conducted with 50 young women and their male partners in northern California in 2015–2016. Survey data were used to descriptively analyze six existing pregnancy ambivalence measures; in‐depth interviews addressing pregnancy desires and plans were deductively coded and thematically analyzed to understand why some participants appeared to be ambivalent from the survey data when their interview responses suggested otherwise.RESULTSEighty participants would be considered ambivalent by at least one measure. After assessment of the interview data, however, these measures were deemed to have misclassified almost all (78) participants. Qualitative analysis revealed several themes regarding misclassification: conflation of current pregnancy desires with expected postconception emotional responses; acceptability of an undesired pregnancy; tempering of survey responses to account for partners’ desires; perceived lack of control regarding pregnancy; and, among participants with medical conditions perceived to impact fertility, subjugation of pregnancy desires in the interest of self‐protection.CONCLUSIONSCurrent approaches to measuring pregnancy ambivalence may fail to capture the intricacies of pregnancy intentions and may be ineffective if they do not account for young people's experiences, especially when used to inform clinical practice, programs and policy.
Lovecraft Laughing
Authors: Hegyi Pál 
Published: February 2019

The horror author infamously famous for his listless, gaunt, lantern-jawed face, H. P. Lovecraft is smiling. This picture is the only such one. The effect is uncanny. Weird it may be, it is not the rare occasion that horror geeks or slasher fans cannot help but ask themselves of the appeal in horror fiction. Is it just the gory scenes? Only cheap thrills compared to something far more hideous, a dread unfathomable to the richest of imaginations? An answer seems to be lurking behind Lovecraft’s enigmatic smile. His monsters crawl out of the most unexpected cracks of our culture, no marvel that Michel Houellebecq, an ardent reader of the Lovecraftian oeuvre himself, becomes mystified upon meeting Lovecraft’s fans: “They have not read his work and don’t even intend to do so. Nonetheless, oddly, they want to find out more—beyond the texts […].”Indeed, as if it wasn’t the most imperative question of them all, the ultimate riddle: what is beyond the texts? What connects Herman Melville and Henry James to H. P. Lovecraft, and through him, to John Carpenter, Ridley Scott, and video games? Is there a secret code hidden in the cypher of one of Sigmund Freud’s most elusive writings? Impossible to tell. Lovecraft’s paroxysm is a caveat here: “The Thing cannot be described—there is no language for such abysms of shrieking and immemorial lunacy, such eldritch contradictions of all matter, force, and cosmic order.” Then what is it that we read, watch, and play, if not the Thing itself?
A Case of Evan's Syndrome Induced by Vedolizumab
Authors: Jen Henry , Morganstern Bradley , D'Souza Lionel 
Published: February 2019

Abstract
Vedolizumab is a monoclonal antibody against the ɑ4β7 integrin receptor used for the treatment of ulcerative colitis and Crohn's disease. Clinical trials have shown vedolizumab to be a safe and highly effective therapy in treating inflammatory bowel disease. Its unique gut-specific mechanism of action has made it an attractive agent in recent years. However, vedolizumab's side effect profile and long-term effects are not fully understood. We report a patient with ulcerative colitis who presented with epistaxis 1 week after receiving the first induction dose of vedolizumab found to have a severe immune-mediated thrombocytopenia and hemolytic anemia, otherwise known as Evan's syndrome.
Measurement of S100B protein: evaluation of a new prototype on a bioMérieux Vidas® 3 analyzer
Authors: Oris Charlotte , Chabanne Russel , Durif Julie , Kahouadji Samy , Brailova Marina , Sapin Vincent , Bouvier Damien 
Published: February 2019

Abstract

Background
The addition of S100B protein to guidelines for the management of mild traumatic brain injury (mTBI) decreases the amount of unnecessary computed tomography (CT) scans with a significant decrease in radiation exposure and an increase in cost savings. Both DiaSorin and Roche Diagnostics have developed automated assays for S100B determination. Recently, bioMérieux developed a prototype immunoassay for serum S100B determination. For the first time, we present the evaluation of the S100B measurement using a bioMérieux Vidas® 3 analyzer.

Methods
We evaluated the matrix effects of serum and plasma, and their stability after storage at 2–8 °C, −20 °C and −80 °C. The new measurement prototype (bioMérieux) was compared with an established one (Roche Diagnostics), and a precision study was also conducted. Lastly, clinical diagnostics performance of the bioMérieux and Roche Diagnostics methods were compared for 80 patients referred to the Emergency Department for mTBI.

Results
Stability after storage at 2–8 °C, −20 °C, and −80 °C and validation of the serum matrix were demonstrated. The bioMérieux analyzer was compared to the Roche Diagnostics system, and the analytical precision was found to be efficient. Clinical diagnosis performance evaluation confirmed the predictive negative value of S100B in the management of mTBI.

Conclusions
The study’s data are useful for interpreting serum S100B results on a bioMérieux Vidas® 3 analyzer.
Influence of silane/MaPE dual coupling agents on the rheological and mechanical properties of sawdust/rubber/HDPE composites
Authors: Xu Xinwu , Chen Ling , Han Jingquan , Zhan Xianxu 
Published: February 2019

Abstract
Proper utilization of recycled rubber is of high environmental and resource concern. In this study, a composite (COMP) was created based on high-density fiberboard sawdust (HDFS), ground tire rubber (GTR) particles and virgin high-density polyethylene (HDPE) with the ratio of HDFS:GTR:HDPE=30:21:49 and with 1% PE wax as lubricant. A dual coupling agent system, i.e. bis-(triethoxysilylpropyl) tetrasulfide (TESPT, up to 5% based on the COMP total weight) together with maleated polyethylene (MaPE, 3, 5 and 8% based on the COMP weight), was applied. The rheological properties of the hybrid during the extrusion process was evaluated in a HAAKE miniLab rheometer, and the bending and tensile properties of injected COMP were tested. The results showed that addition of MaPE and TESPT has an evident influence on the shear viscosity and stress of the COMP fluid, and the two coupling chemicals have synergetic effects. Increased content of MaPE and/or TESPT improved the tensile and bending strength of the COMP, while excessive addition of TESPT (over 1%) decreased the bending modulus. To conclude, a dual coupling system, 5% MaPE plus 1% TESPT, seems to be advantageous for the COMP behavior.
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson’s Disease
Authors: Sebastián-Pérez Víctor , Martínez María Jimena , Gil Carmen , Campillo Nuria Eugenia , Martínez Ana , Ponzoni Ignacio 
Published: February 2019

Abstract
Parkinson’s disease is one of the most common neurodegenerative illnesses in older persons and the leucine-rich repeat kinase 2 (LRRK2) is an auspicious target for its pharmacological treatment. In this work, quantitative structure–activity relationship (QSAR) models for identification of putative inhibitors of LRRK2 protein are developed by using an in-house chemical library and several machine learning techniques. The methodology applied in this paper has two steps: first, alternative subsets of molecular descriptors useful for characterizing LRRK2 inhibitors are chosen by a multi-objective feature selection method; secondly, QSAR models are learned by using these subsets and three different strategies for supervised learning. The qualities of all these QSAR models are compared by classical metrics and the best models are discussed in statistical and physicochemical terms.
Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women
Authors: Melo Júnior José Francisco , Bravo-valenzuela Nathalie Jeanne , Nardozza Luciano Marcondes Machado , Peixoto Alberto Borges , Mattar Rosiane , Martins Wellington P. , Tonni Gabriele , Araujo Júnior Edward 
Published: February 2019

Abstract

Objective
To determine the reference range for the myocardial area in healthy fetuses using three-dimensional (3D) ultrasonography and validate these results in fetuses of pregnant women with pre-gestational diabetes mellitus (DM).

Methods
This cross-sectional retrospective study included 168 healthy pregnant women between gestational weeks 20 and 33+6 days. The myocardial area was measured using spatio-temporal image correlation (STIC) in the four-chamber view. Polynomial regression models were used, and the goodness of fit of the models were evaluated by the coefficient of determination (R2). Intra- and inter-observer reproducibility was determined using the concordance correlation coefficient (CCC). Validation was performed in 30 pregnant women with pre-gestational DM.

Results
There was a strong correlation (R2=0.71, P<0.0001) between myocardial area and gestational age. There was good intra- and inter-observer reproducibility, with a CCC of 0.86 and 0.83, respectively. However, there was no significant difference in the mean myocardial area between healthy fetuses and fetuses of women with pre-gestational DM (0.11 cm2, P=0.55).

Conclusion
The reference range was determined for the myocardial area in fetuses, and there was no significant difference in this variable between healthy fetuses and the fetuses of women with pre-gestational DM.
A high concentration of fetal fibronectin in cervical secretions increases the risk of intra-amniotic infection and inflammation in patients with preterm labor and intact membranes
Authors: Oh Kyung Joon , Romero Roberto , Park Jee Yoon , Kang Jihyun , Hong Joon-Seok , Yoon Bo Hyun 
Published: February 2019

Abstract

Objective
To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes.

Methods
This prospective study included 180 patients with preterm labor and intact membranes who had a sample collected for quantitative fFN measurement and underwent amniocentesis. Amniotic fluid was cultured for aerobic and anaerobic bacteria and genital mycoplasmas. Intra-amniotic inflammation was defined as an amniotic fluid matrix metalloproteinase-8 concentration >23 ng/mL.

Results
(1) The prevalence of intra-amniotic infection/inflammation and SPTD within 7 days was 32.2% (58/180) and 33.9% (61/178), respectively; (2) The higher the fFN concentration, the greater the risk of intra-amniotic infection/inflammation and SPTD within 7 days (P<0.001, respectively); (3) An fFN concentration 150 ng/mL had a better diagnostic performance than an fFN 50 ng/mL in the identification of intra-amniotic infection/inflammation and SPTD within 7 days; (4) Among the patients with an fFN <50 ng/mL, intra-amniotic infection/inflammation was identified in 7.6% (6/79) of patients and 66.7% (4/6) delivered within 7 days.

Conclusion
The higher the concentration of fFN, the greater the risk of intra-amniotic infection/inflammation and SPTD in patients with preterm labor and intact membranes.