bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenital mesoblastic nephroma: a single-centre series
Authors: Pachl M , Arul GS , Jester I , Bowen C , Hobin D , Morland B 
Published: September 2019

Background Congenital mesoblastic nephroma is a rare disease. Treatment is surgical in the first instance. Chemotherapy has traditionally been thought not to have a role. Recent literature suggests a 50% mortality rate for recurrent/metastatic disease. Materials and methods This study is a retrospective case review of prospectively collected data. Demographics, histopathology, treatment, outcomes and follow up were reviewed. Results Nine patients, 6 male and 3 female, were included. The median age at presentation was one month (range 0–7 months); follow-up was for a median of 21.5 months (range 16–79 months). Two patients had mixed and classical subtypes and the other five had the cellular subtype. Surgery was completed by an open procedure in eight patients and laparoscopically in one. There were three recurrences; two were local and one was pulmonary. Recurrences were treated with a combination of chemotherapy, radiotherapy and surgery. One patient with recurrent disease died from acute-on-chronic respiratory failure secondary to lung irradiation but was disease free. The other eight are disease free, alive and well with no sequelae at latest follow-up. Conclusions Surgery remains the mainstay of management with chemo- and radiotherapy reserved for unresectable tumours or adjuvant management of recurrent disease. Specimen-positive margins are not an indication for instituting chemotherapy. The tyrosine kinase pathway seems to be a potential target for future chemotherapeutic agents although it is too early to assess how that will impact on the management of congenital mesoblastic nephroma.
Linguistically and culturally relevant education on the roof of the world: The collaborative creation of a Ladakhi storybook
Authors: Dowd Patrick 
Published: September 2019

This article describes the creation of a culturally and linguistically relevant storybook written for 10–12-year-old children in the Ladakh, a high-altitude region of the Indian Himalayas. Formerly a part of the Tibetan Empire, Ladakh came under Indian rule in the mid-nineteenth century but maintained strong autonomy and close ties with its neighbour to the north until China closed the Ladakh-Tibet border in the late 1950s. In the 1970s the Indian government opened the Ladakh to tourism which resulted in rapid change, transforming the preindustrial, largely agrarian society into one heavily dependent on tourism. In a region where the total population is less than 275,000, in 2016 alone nearly 240,000 tourists visited Ladakh, almost 200,000 of whom were Indian. Language shift from Ladakhi to Hindi and English, as well as a profound sense of cultural alienation, are among the unintended consequences of the tourist industry and thorough incorporation of Ladakh into the Indian market economy.
Having interviewed numerous teachers, principals, and education activists in the summer of 2016, they nearly unanimously argued that the lack of culturally relevant, Ladakhi-centric material was a major reason young Ladakhis failed to learn their language well and the cultural values embedded within it. I returned to Ladakh in August 2017 to work with a team of local Ladakhi university students, writers and illustrators to produce a children’s storybook rooted in the people, landscape, language and culture of Ladakh. 1,000 copies were printed in February 2018 and are currently being distributed in Ladakh by the Himalayan Cultural Heritage Foundation. The article describes the collaborative research, writing and illustration that produced the book, as well as how we navigated the delicate balance of honouring colloquial Ladakhi while still respecting the grammar and spelling of the literary Tibetan language on which it is based.
Decriminalising Ornament: The Pleasures of Pattern: The sympathy of illustration
Authors: Hoogslag Nanette 
Published: September 2019

This article reflects on the research exhibition Decriminalising Ornament: The Pleasures of Pattern held in the Ruskin Gallery in Cambridge in November 2018 in conjunction with the International Illustration Research Conference of the same name. It considers the role of ornament and decoration in the exhibited works and through this the essential presence of the decorative within illustration.
Key is Lars Spuybroek's concept of sympathy, which he develops based on a premodern understanding of ornamentation. In response to Spuybroek's exploration of this concept, this article seeks to extend the notion of sympathy as an essential presence within illustration. Sympathy indicates a human-material relationship not just between the illustrator and the creative materials, but also in the readers connection with this decorative act in the reproduced illustration.
La intimidad del estudio como forma de vida
Authors: Bárcena Orbe Fernando 
Published: September 2019

El objetivo de este ensayo es una exploración de la intimidad del estudio considerado como una forma de vida. El punto de partida que sirve de inspiración aquí es doble. Por una parte, la antigua tradición grecolatina que entendía la actividad filosófica como un ejercicio espiritual (como un arte de vivir o como un cuidado de sí). Desde esta perspectiva, el estudio (al mismo tiempo una actividad que se realiza y un lugar de exilio estudioso) -referido a esta noción griega de «espiritualidad»- consiste en la experiencia por medio de la cual el sujeto (estudioso) efectúa en sí mismo las transformaciones necesarias para tener acceso a la verdad de sus asuntos, donde se quiebran las relaciones tradicionales del adentro y del afuera, lo interior y lo exterior. Lo que aquí se postula, entonces, es que la verdad no se ofrece al sujeto como un mero acto de conocimiento, sino que es preciso que se modifique, transforme y se convierta en distinto de sí mismo para tener derecho de acceso a la verdad. Se establece, entonces, una relación muy diferente -a la que predomina en los discursos pedagógicos contemporáneos de la llamada sociedad del aprendizaje (que ponen el acento en el aprender, pero no en el estudiar)- entre el sujeto y el saber. Por otro lado, este texto se sirve de una imagen determinada, que trata de dar cuenta de un aspecto central de la intimidad del estudio: como Penélope, que teje y desteje cada día una tela funeraria mientras espera el regreso de Ulises, para así poder resistirse a la presión de sus acosadores, el estudio es una actividad interminable que, en cada jornada, el estudioso repite los mismos gestos (en el leer, el pensar y el escribir), gestos que le permiten sostenerse en la larga fatiga del estudio y sustraerse a la presión ejercida por una idea de la educación que ha de estar volcada siempre a los resultados y a las utilidades. En este ensayo se explora, de acuerdo con todo esto, el estudio como una actividad interminable donde se ejerce el tiempo libre en una modalidad de exilio estudioso, en la que la práctica de la lectura y la escrita de anotaciones sostienen al estudioso en la larga fatiga del estudiar.
USULAN PERBAIKAN SUMBER BAHAYA PADA AREA ASSEMBLY 2 DENGAN METODE HAZARD AND OPERABILITY STUDY DAN FAULT TREE ANALYSIS (STUDI KASUS: PT. ASTRA DAIHATSU MOTOR)
Authors: Saptadi Singgih , Ardi Fahmi 
Published: September 2019

Perkembangan industri di Indonesia, khususnya pada industri manufaktur, mengalami kemajuan yang cukup pesat. Populasi tenaga kerja industri bertambah seiring perkembangan industri dan nilai tambah industri nasional yang meningkat dengan jumlah sebanyak 30,992 orang pada tahun 2018, meningkat 17,92% dibanding tahun 2017. Namun, masalah dan penanggulangan pada kasus kecelakaan kerja masih kurang diperhatikan, dibarengi dengan jumlah kecelakaan kerja yang masih tinggi, tidak terkecuali di PT. Astra Daihatsu Motor. Maka dari itu penelitian dilakukan di area Assembly 2 di area pabrik PT. Astra Daihatsu Motor di kawasan Sunter, Jakarta, dengan metode Hazard and Operability Study (HAZOP) dan Fault Tree Analysis (FTA) untuk mengetahui potensi bahaya secara teliti serta mengungkap unsur-unsur yang berpotensi berbahaya dalam sistem. Pada penelitian ini ditemukan sebanyak 17 sumber bahaya dengan 2 sumber termasuk dalam level risiko tinggi, 3 sumber level risiko sedang, dan 12 sumber level risiko rendah. Analisis deduktif dengan Fault Tree Analysis didapatkan hasil dengan munculnya 5 basic event dari Thinner dan 4 basic event dari Lampu Heater dengan rekomendasi perbaikan pada aspek desain, konstruksi, dan pelatihan handling yang baik pada material tersebut. Abstract[Proposed Improvement of Hazard Sources In The Area of Assembly 2 With The Hazard And Operability Study And Fault Tree Analysis (Case Study: PT. Astra Daihatsu Motor)]The development of industry in Indonesia, especially in the manufacturing industry, has experienced rapid progress. The industrial labor population increased as industry development and national industrial value added increased by as many as 30,992 people in 2018, an increase of 17.92% compared to 2017. However, the prevention and countermeasures in cases of workplace accidents are still not considered as priority, including in PT. Astra Daihatsu Motor. Therefore a research has been conducted in the Assembly 2 area at the PT. Astra Daihatsu Motor in the Sunter area, Jakarta, using the applicability of Hazard and Operability Study (HAZOP) method and the Fault Tree Analysis (FTA) method to carefully identify potential hazards and reveal potentially dangerous elements in the system. In this study 17 sources of hazards were found with 2 sources including high risk level, 3 medium risk level sources, and 12 low risk level sources. Deductive analysis with Fault Tree Analysis is obtained, namely 5 basic events from Thinner and 4 basic events from the Heater Lamps with recommendations on aspects of design, construction, and handling training in the material.Keywords: work accident; hazard and operability; risk level; fault tree analysis
Same-Sex Marriage and Italian Exceptionalism
Authors: Winkler Matteo M 
Published: September 2019

Abstract
This article unveils Italy’s exceptionalism in recognising and protecting same-sex couples by adopting a three-dimension analysis: constitutional, comparative and supranational. It maintains that, compared to other countries whose courts were sympathetic with the legal claims raised by lesbian and gay people, Italy’s Constitutional Court adopted a totally different approach, reinforcing the heteronormativity of marriage in a way that delayed all efforts to pass a law on same-sex registered partnerships. The Constitutional Court, in particular, interpreted the Constitution, the experience of other nations and supranational law according to heteronormativity, an example that is unique in the comparative context. As an illustration, this article addresses the case Bernaroli vs Ministry of the Interior. In Bernaroli, a male-to-female transgender person wanted to remain married to her wife notwithstanding the transition. The case ignited a heated debate among scholars and questioned the courts’ opinions as to the human rights dynamics surrounding same-sex marriage and, more importantly, about the current role of heteronormativity in marriage law. This article concludes that the legal existence of Bernaroli’s marriage represents a constant challenge to the status quo and highlights the permanent crisis of heteronormativity. After the Austrian Constitutional Court’s recent ruling that declared the law on same-sex domestic partnership to be discriminatory, heteronormativity’s defence became even more untenable, making Italy’s a true exception in the continent’s legal landscape.
A Non-Canonical Cortico-Amygdala Inhibitory Loop
Authors: Bertero Alice , Feyen Paul Luc Caroline , Zurita Hector , Apicella Alfonso junior 
Published: September 2019

Discriminating between auditory signals of different affective value is critical for the survival and success of social interaction of an individual. Anatomical, electrophysiological, imaging, and optogenetics approaches have established that the auditory cortex (AC) by providing auditory information to the lateral amygdala (LA) via long-range excitatory glutamatergic projections has an impact on sound-driven aversive/fear behavior. Here we test the hypothesis that the LA also receives GABAergic projections from the cortex. We addressed this fundamental question by taking advantage of optogenetics, anatomical, and electrophysiology approaches and directly examining the functional effects of cortical GABAergic inputs to LA neurons of the mouse (male/female) AC. We found that the cortex, via cortico-lateral-amygdala somatostatin neurons (CLA-SOM), has a direct inhibitory influence on the output of the LA principal neurons. Our results define a CLA long-range inhibitory circuit (CLA-SOM inhibitory projections → LA principal neurons) underlying the control of spike timing/generation in LA and LA–AC projecting neurons, and attributes a specific function to a genetically defined type of cortical long-range GABAergic neurons in CLA communication.SIGNIFICANCE STATEMENTIt is very well established that cortical auditory inputs to the lateral amygdala are exclusively excitatory and that cortico-amygdala neuronal activity has been shown to be involved in sound-driven aversive/fear behavior. Here, for the first time, we show that the lateral amygdala receives long-range GABAergic projection from the auditory cortex and these form direct monosynaptic inhibitory connections onto lateral amygdala principal neurons. Our results define a cellular basis for direct inhibitory communication from auditory cortex to the lateral amygdala, suggesting that the timing and ratio of excitation and inhibition, two opposing forces in the mammalian cerebral cortex, can dynamically affect the output of the lateral amygdala, providing a general mechanism for fear/aversive behavior driven by auditory stimuli.
Programmed Chromosome Deletion in the Ciliate Oxytricha trifallax
Authors: Clay Derek M , Yerlici V Talya , Villano Danylo J , Landweber Laura F 
Published: September 2019

Abstract
The ciliate Oxytricha trifallax contains two nuclei: a germline micronucleus and a somatic macronucleus. These two nuclei diverge significantly in genomic structure. The micronucleus contains approximately 100 chromosomes of megabase scale, while the macronucleus contains 16,000 gene-sized, high ploidy “nanochromosomes.” During its sexual cycle, a copy of the zygotic germline micronucleus develops into a somatic macronucleus via DNA excision and rearrangement. The rearrangement process is guided by multiple RNA-based pathways that program the epigenetic inheritance of sequences in the parental macronucleus of the subsequent generation. Here, we show that the introduction of synthetic DNA molecules homologous to a complete native nanochromosome during the rearrangement process results in either loss or heavy copy number reduction of the targeted nanochromosome in the macronucleus of the subsequent generation. This phenomenon was tested on a variety of nanochromosomes with different micronuclear structures, with deletions resulting in all cases. Deletion of the targeted nanochromosome results in the loss of expression of the targeted genes, including gene knockout phenotypes that were phenocopied using alternative knockdown approaches. Further investigation of the chromosome deletion showed that, although the full length nanochromosome was lost, remnants of the targeted chromosome remain. We were also able to detect the presence of telomeres on these remnants. The chromosome deletions and remnants are epigenetically inherited when backcrossed to wild type strains, suggesting that an undiscovered mechanism programs DNA elimination and cytoplasmically transfers to both daughter cells during conjugation. Programmed deletion of targeted chromosomes provides a novel approach to investigate genome rearrangement and expands the available strategies for gene knockout in Oxytricha trifallax.
Genome-Wide Variant Identification and High-Density Genetic Map Construction Using RADseq for Platycladus orientalis (Cupressaceae)
Authors: Jin Yuqing , Zhao Wei , Nie Shuai , Liu Si-Si , El-Kassaby Yousry A , Wang Xiao-Ru , Mao Jian-Feng 
Published: September 2019

Abstract
Platycladus orientalis is an ecologically important native conifer in Northern China and exotic species in many parts of the world; however, knowledge about the species’ genetics and genome are very limited. The availability of well-developed battery of genetic markers, with large genome coverage, is a prerequisite for the species genetic dissection of adaptive attributes and efficient selective breeding. Here, we present a genome-wide genotyping method with double-digestion restriction site associated DNA sequencing (ddRAD-seq) that is effective in generating large number of Mendelian markers for genome mapping and other genetic applications. Using 139 megagametophytes collected from a single mother tree, we assembled 397,226 loci, of which 108,683 (27.4%) were polymorphic. After stringent filtering for 1:1 segregation ratio and missing rate of &lt;20%, the remaining 23,926 loci (22% of the polymorphic loci) were ordered into 11 linkage groups (LGs) and distributed across 7,559 unique positions, with a total map length of 1,443 cM and an average spacing of 0.2 cM between adjacent unique positions. The 11 LGs correspond to the species’ 11 haploid genome chromosome number. This genetic map is among few high-density maps available for conifers to date, and represents the first genetic map for P. orientalis. The information generated serves as a solid foundation not only for marker-assisted breeding efforts, but also for comparative conifer genomic studies.
InstructableCrowd: Creating IF-THEN Rules for Smartphones via Conversations with the Crowd
Authors: Huang Ting-Hao K. , Azaria Amos , Romero Oscar J. , Bigham Jeffrey P. 
Published: September 2019

Natural language interfaces have become a common part of modern digital life. Chatbots utilize text-based conversations to communicate with users; personal assistants on smartphones such as Google Assistant take direct speech commands from their users; and speech-controlled devices such as Amazon Echo use voice as their only input mode. In this paper, we introduce InstructableCrowd, a crowd-powered system that allows users to program their devices via conversation. The user verbally expresses a problem to the system, in which a group of crowd workers collectively respond and program relevant multi-part IF-THEN rules to help the user. The IF-THEN rules generated by InstructableCrowd connect relevant sensor combinations (e.g., location, weather, device acceleration, etc.) to useful effectors (e.g., text messages, device alarms, etc.). Our study showed that non-programmers can use the conversational interface of InstructableCrowd to create IF-THEN rules that have similar quality compared with the rules created manually. InstructableCrowd generally illustrates how users may converse with their devices, not only to trigger simple voice commands, but also to personalize their increasingly powerful and complicated devices.
New Looks On Abaya as National Identity of United Arab Emirates
Authors: Marifatullah Alfida , Marifatullah Alfida 
Published: September 2019

This research discusses the new looks on the abaya which is being part of national identity in the United Arab Emirates and even more widely, abaya was accepted as an Arab culture by fashion lovers all over the world. The government boost preservation of abaya that already becomes a lifestyle of Arabs women by assigning this robe as the national dress. This research uses the qualitative method by using fashion theory from Douglas who said that anxiety is a source of fashion changes. This study shows that fashion changes due to anxiety and wants to bring change or replace it with a new one. In the United Arab Emirates, the changes of fashion occur because the citizens want to set the abaya to be timeless culture. New looks on abaya bring out the question; How government and individuals protecting abaya from fashion changes in United Arab Emirate? The result of this study is line with the concept of Douglas about fashion; that fashion are created not only to validate or display dominant and accepted categories of identity, but also to out cultural anxiety.The changes that had already done by UAE people not only bring to the "new" UAE, but it was for preservasing culture and history of UAE.
Accumulation of degree days and their effect on the potential yield of 15 eggplant (Solanum melongena L.) accessions in the Colombian Caribbean
Authors: León Pacheco Rommel Igor , Correa Álvarez Ender Manuel , Romero Ferrer Jorge Luis , Arias Bonilla Heriberto , Gómez-Correa Juan Camilo , Yacomelo Hernández Marlon Jose , Pérez Artiles Lumey 
Published: September 2019

The growing degree-days (GDD) provide an estimate of the accumulated thermal energy available for the development of a crop. The use of GDD allows measuring the heat requirements associated with the phenological stages of the crop, which allows in turn, to predict when a certain plant stage will occur knowing the daily temperatures. The aim of this study was to establish relationships among the effect of degree days (DD) to vegetative growth, first flowering and fructification (VG, Fl and Fr), on total yield per plant (TY/P) of eggplant grown under open-field conditions employing a randomized complete block design with 15 genotypes and four replicates. The results showed that: 1) The genotypes that initiated fruit production in less time required fewer GDD (892.14-1,077.71 °C) for this phenological phase, obtaining higher productivity. 2) The genotypes C035 and C040 had an average yield higher than the national average with values of 83.75 and 84.86 t ha-1, being identified as future varieties to be produced in the Caribbean region. 3) The Caribbean region is suitable for the establishment of the crop as there were no events with limiting temperatures for this species (higher than 35 °C and lower than 15 °C). 4) The principal component analysis showed associations among the variable YT/P with the genotypes C011, C042, and C015; meanwhile, C032, C025, and C028 were associated with the variables DD to VG, Fl, and Fr. These results would be useful in developing a model to estimate yield with DD.