bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher mortality and hospital charges in patients with cirrhosis and acute respiratory illness: a population-based study
Authors: Zou Biyao , Yeo Yee Hui , Jeong Donghak , Sheen Edward , Park Haesuk , Nguyen Pauline , Hsu Yao-Chun , Garcia Gabriel , Nguyen Mindie H. 
Published: June 2018

AbstractBoth cirrhosis and acute respiratory illness (ARI) carry substantial disease and financial burden. To compare hospitalized patients with cirrhosis with ARI to cirrhotic patients without ARI, a retrospective cohort study was conducted using the California Office of Statewide Health Planning and Development database. To balance the groups, propensity score matching (PSM) was used. We identified a total of 46,192 cirrhotic patients during the three study periods (14,049, 15,699, and 16,444 patients, respectively). Among patients hospitalized with cirrhosis, the ARI prevalence was higher in older age groups (p < 0.001), the Asian population (p = 0.002), non-Hispanic population (p = 0.001), and among Medicare patients (p < 0.001). Compared to controls, patients with ARI had 53.8% higher adjusted hospital charge ($122,555 vs. $79,685 per patient per admission, p < 0.001) and 35.0% higher adjusted in-hospital mortality (p < 0.001). Older patients, patients with alcoholic liver disease or liver cancer were at particularly higher risk (adjusted hazard ratio = 2.94 (95% CI: 2.26–3.83), 1.22 (95% CI: 1.02–1.45), and 2.17 (95% CI: 1.76–2.68) respectively, p = 0.028 to <0.001). Mortality rates and hospital charges in hospitalized cirrhotic patients with ARI were higher than in cirrhotic controls without ARI. Preventive efforts such as influenza and pneumococcal vaccination, especially in older patients and those with liver cancer, or alcoholic liver disease, would be of value.
Risk stratifiers for arrhythmic and non-arrhythmic mortality after acute myocardial infarction
Authors: Gañán-Calvo Alfonso M. , Hnatkova Katerina , Romero-Calvo Álvaro , Fajardo-López Juan , Malik Marek 
Published: June 2018

AbstractThe effective discrimination between patients at risk of Arrhythmic Mortality (AM) and Non-Arrhythmic Mortality (NAM) constitutes one of the important unmet clinical needs. Successful risk assessment based on Electrocardiography (ECG) records is greatly improved by the combination of different indices reflecting not only the pathological substrate but also the autonomic regulation of cardiac electrophysiology. This study assesses the cardiac risk stratification capacity of two new Heart Rate Variability (HRV) parameters, Breath Concurrence 6 (BC6) -sinusoidal RR variability of 6 heart beats per breath cycle- and Primary Ectopia (PE) -presence of early ventricular contractions of any etiology- together with the Deceleration Capacity (DC). While BC6 characterizes the response to physiological and pathophysiological stimuli, PE qualifies autonomic cardiac electrophysiology. The analysis of the European Myocardial Infarct Amiodarone Trial (EMIAT) database indicates that BC6 is related with the risk of Arrhythmic Mortality (AM) and PE with the risk of Non-Arrhythmic Mortality. BC6 is the only single parameter that significantly discriminates between AM and NAM. While the combination of BC6 and DC contributes to the identification of AM risk, PE together with DC improves the prediction of NAM in patients with severe ischemic heart disease.
Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study
Authors: Wang Kunling , Wei Hongyan , Zhang Wanqi , Li Zhen , Ding Li , Yu Tong , Tan Long , Liu Yaxin , Liu Tong , Wang Hao , Fan Yuxin , Zhang Peng , Shan Zhongyan , Zhu Mei 
Published: June 2018

AbstractTrace elements, such as iodine and selenium, are closely related to autoimmune thyroiditis and thyroid function. Low serum magnesium is associated with several chronic diseases; however, its associations with autoimmune thyroiditis and thyroid function are unclear. We investigated the relationships between low serum magnesium, autoimmune thyroiditis, and thyroid function in 1,257 Chinese participants. Demographic data were collected via questionnaires, and levels of serum thyroid stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody (TGAb), free thyroxine, serum magnesium, serum iodine, and urinary iodine concentration were measured. Participants were divided into serum magnesium level quartiles (≤0.55, 0.551–0.85, 0.851–1.15, and >1.15 mmol/L). The median serum magnesium level was 0.89 (0.73–1.06) mmol/L; levels ≤0.55 mmol/L were considered severely low (5.9% of participants). The risks of TGAb positivity and Hashimoto thyroiditis (HT) diagnosed using ultrasonography in the lowest quartile group were higher than those in the adequate magnesium group (0.851–1.15 mmol/L) (p < 0.01, odds ratios [ORs] = 2.748–3.236). The risks of total and subclinical-only hypothyroidism in the lowest quartile group were higher than those in the adequate magnesium group (0.851–1.15 mmol/L) (p < 0.01, ORs = 4.482–4.971). Severely low serum magnesium levels are associated with an increased rate of TGAb positivity, HT, and hypothyroidism.
HECIL: A Hybrid Error Correction Algorithm for Long Reads with Iterative Learning
Authors: Choudhury Olivia , Chakrabarty Ankush , Emrich Scott J. 
Published: June 2018

AbstractSecond-generation DNA sequencing techniques generate short reads that can result in fragmented genome assemblies. Third-generation sequencing platforms mitigate this limitation by producing longer reads that span across complex and repetitive regions. However, the usefulness of such long reads is limited because of high sequencing error rates. To exploit the full potential of these longer reads, it is imperative to correct the underlying errors. We propose HECIL—Hybrid Error Correction with Iterative Learning—a hybrid error correction framework that determines a correction policy for erroneous long reads, based on optimal combinations of decision weights obtained from short read alignments. We demonstrate that HECIL outperforms state-of-the-art error correction algorithms for an overwhelming majority of evaluation metrics on diverse, real-world data sets including E. coli, S. cerevisiae, and the malaria vector mosquito A. funestus. Additionally, we provide an optional avenue of improving the performance of HECIL’s core algorithm by introducing an iterative learning paradigm that enhances the correction policy at each iteration by incorporating knowledge gathered from previous iterations via data-driven confidence metrics assigned to prior corrections.
Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli
Authors: Germond Arno , Ichimura Taro , Horinouchi Takaaki , Fujita Hideaki , Furusawa Chikara , Watanabe Tomonobu M. 
Published: June 2018

AbstractTo be able to predict antibiotic resistance in bacteria from fast label-free microscopic observations would benefit a broad range of applications in the biological and biomedical fields. Here, we demonstrate the utility of label-free Raman spectroscopy in monitoring the type of resistance and the mode of action of acquired resistance in a bacterial population of Escherichia coli, in the absence of antibiotics. Our findings are reproducible. Moreover, we identified spectral regions that best predicted the modes of action and explored whether the Raman signatures could be linked to the genetic basis of acquired resistance. Spectral peak intensities significantly correlated (False Discovery Rate, p < 0.05) with the gene expression of some genes contributing to antibiotic resistance genes. These results suggest that the acquisition of antibiotic resistance leads to broad metabolic effects reflected through Raman spectral signatures and gene expression changes, hinting at a possible relation between these two layers of complementary information.
Réacteurs à neutrons rapides sodium : vers une acceleration du programme chinois ?
Authors: Guidez Joel , Lasou Sabine 
Published: June 2018

La Chine a affirmé à plusieurs reprises son ambition de fermer le cycle nucléaire. Dans cette optique, d’importants efforts de recherche ont été engagés pour le développement de réacteurs à neutrons rapides (RNR), lesquels pourraient faire partie du mix chinois d’ici 2050.
La Chine accélère son programme de RNR sodium. Un démonstrateur (CFR-600) est actuellement en construction pour un démarrage prévu en 2023. Selon la CNNC, plus grande entreprise publique de l’industrie nucléaire du pays, 5 prototypes industriels (CFR-600) pourraient être construits pour 2030, suivis du projet commercial (CFR-1000).
Schmerzen erfolgreich behandeln mit Myoreflextherapie
Authors: Mosetter Kurt 
Published: June 2018

ZusammenfassungBei der Myoreflextherapie geht es um die unmittelbare Lösung der zu hohen Grundspannung im Muskel/Muskelsystem und damit um die Entlastung von Gelenken und Weichteilstrukturen.In erster Linie werden Muskelansätze in funktionellen Zusammenhängen und kinetischen Ketten behandelt. Berührungsreize werden dort verstärkt wahrgenommen, bereits eine leichte Druckerhöhung kann zu Schmerzen mit Ausstrahlungen an entfernten Stellen führen. Bei der Palpation finden sich häufig schmerzhafte Verhärtungen, Myogelosen und bindegewebige Aufquellungen. An den entsprechenden Muskeln ist ein Hypertonus festzustellen. Nach Druckpunktstimulation lösen sich die tastbaren Veränderungen nach einer gewissen Zeit auf. Über einen allmählichen manuellen Druckanstieg am Muskel-Sehnen-Knochen-Übergang werden neuromuskuläre und bindegewebige Reaktionen ausgelöst, der Tonus der entsprechenden Muskeln sinkt ab. Umstellungsreize veranlassen den Organismus zu entsprechenden Regulationen und zur Wiederherstellung einer funktionstüchtigen, schmerzfreien Anatomie des Bewegungssystems.
Opportunistic Salpingectomy at the Time of Benign Laparoscopic Hysterectomy: Assessment of Possible Complications and Histopathological p53-Signatures
Authors: Chene Gautier , Urvoas Sarah , Moret Stéphanie , Nadaud Béatrice , Buenerd Annie , Chabert Philippe , Mellier Georges , Lamblin Gery 
Published: June 2018

Abstract
Introduction The aim of this study is to assess the prevalence of tubal histopathological abnormalities (serous tubal intraepithelial carcinoma STIC and p53 signatures) and the prevalence of perioperative and postoperative complications related to opportunistic laparoscopic salpingectomy in a low risk population.
Materials and Methods In this observational prospective cohort, prophylactic bilateral salpingectomy during benign laparoscopic hysterectomy was systematically performed in 100 consecutive women. Peri- and postoperative complications were registered. Duration of salpingectomy and post-salpingectomy blood loss were also measured. Histopathological and immunohistochemical analysis with anti-p53 antibody were performed on the whole fallopian tubes according to a specific and validated protocol.
Results Laparoscopic salpingectomy was always possible without any peri- or postoperative complication attributable to the salpingectomy itself. The mean duration was 428 seconds (354 – 596) and the blood loss was 9 cm3 (2 – 15). Using histopathological and immunohistochemical assessment with anti-p53 antibody on 199 fallopian tubes (99 bilateral salpingectomies and one unilateral salpingectomy because of previous salpingectomy for ectopic pregnancy), there was a prevalence of 5.52% (11/199) of p53 signatures. No STIC were observed and no associated cancer.
Conclusions Laparoscopic salpingectomy is both feasible and innocuous during benign hysterectomy. Meticulous histopathologic examination of the tubes may reveal specific abnormalities.
Controversies about the Secondary Prevention of Spontaneous Preterm Birth
Authors: Kyvernitakis Ioannis , Maul Holger , Bahlmann Franz 
Published: June 2018

AbstractPreterm birth is one of the major global health problems and part of the Millennium Development goals because of the associated high number of perinatal or neonatal mortality and long-term risks of neurodevelopmental and metabolic diseases. Transvaginal sonography has meanwhile been established as a screening tool for spontaneous preterm birth despite its relatively low sensitivity when considering only the cervical length. Vaginal progesterone has been shown to reduce prematurity rates below 34 weeks in a screening population of singleton pregnancies. Up to now, no positive long-term effect could be demonstrated after 2 years. It seems to have no benefit to prolong pregnancies after a period of preterm contractions and in risk patients without cervical shortening. Meta-analyses still demonstrate conflicting results dependent on quality criteria used for selection. A cerclage is only indicated in singleton pregnancies with previous spontaneous preterm birth and a combined cervical shortening in the current pregnancy. Nevertheless, the short- and long-term outcome has never been evaluated, whereas maternal complications may be increased. There is no evidence for a prophylactic cervical cerclage in twin pregnancies even in cases with cervical shortening. Emergency cerclage remains an indication after individual counseling. The effect of a cervical pessary in singleton pregnancy seems to be more pronounced in studies where a few investigators with increasing experience have treated and followed the patients at risk for preterm birth. Mainly in twin pregnancies, pessary treatment seems to be promising compared to other treatment options of secondary prevention when the therapy is started at early stages of precocious cervical ripening. At present, several international trials with the goal to reduce global rates of prematurity are in progress which will hopefully allow to specify the indications and methods of intervention for certain subgroups. When trials are summarized, prospective meta-analyses carry a lower risk of bias than the meanwhile uncontrolled magnitude of retrospective meta-analyses with conflicting results.
Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No. 015/082, November 2017) – Recommendations and Statements for Girls and Women
Authors: Dittrich Ralf , Kliesch Sabine , Schüring Andreas , Balcerek Magdalena , Baston-Büst Dunja , Beck Ramona , Beckmann Matthias , Behringer Karolin , Borgmann-Staudt Anja , Cremer Wolfgang , Denzer Christian , Diemer Thorsten , Dorn Almut , Fehm Tanja , Gaase Rüdiger , Germeyer Ariane , Geue Kristina , Ghadjar Pirus , Goeckenjan Maren , Götte Martin , Guth Dagmar , Hauffa Berthold , Hehr Ute , Hetzer Franc , Hirchenhain Jens , Hoffmann Wilfried , Hornemann Beate , Jantke Andreas , Kentenich Heribert , Kiesel Ludwig , Köhn Frank-Michael , Korell Matthias , Lax Sigurd , Liebenthron Jana , Lux Michael , Meißner Julia , Micke Oliver , Nassar Najib , Nawroth Frank , Nordhoff Verena , Ochsendorf Falk , Oppelt Patricia , Pelz Jörg , Rau Beate , Reisch Nicole , Riesenbeck Dorothea , Schlatt Stefan , Sender Annekathrin , Schwab Roxana , Siedentopf Friederike , Thorn Petra , Wagner Steffen , Wildt Ludwig , Wimberger Pauline , Wischmann Tewes , von Wolff Michael , Lotz Laura 
Published: June 2018

Abstract
Aim The aim of this official guideline published by the German Society of Gynecology and Obstetrics (DGGG) and coordinated with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained by evaluating the relevant literature, on counseling and fertility preservation for prepubertal girls and boys as well as patients of reproductive age. Statements and recommendations for girls and women are presented below. Statements or recommendations for boys and men are not the focus of this guideline.
Methods This S2k guideline was developed at the suggestion of the guideline commission of the DGGG, DGU and DGRM and represents the structured consensus of representative members from various professional associations (n = 40).
Recommendations The guideline provides recommendations on counseling and fertility preservation for women and girls which take account of the patientʼs personal circumstances, the planned oncologic therapy and the individual risk profile as well as the preferred approach for selected tumor entities.
Kostentreiber in Gesundheitssystemen – Ursachen für hohe Gesundheitskosten in den USA
Authors: Lichert Frank 
Published: June 2018

Papanicolas I et al. Health Care Spending in the United States and Other High-Income Countries. JAMA 2018; 319: 1024–1039. doi:10.1001/jama.2018.1150
Die USA nehmen im Vergleich zu anderen Ländern mit hohem Einkommen eine Führungsposition bei den Gesundheitsausgaben ein. Dennoch lassen die
Gesundheitsversorgung und Gesundheitsoutcomes der Menschen teilweise zu wünschen übrig. I. Papanicolas et al. haben nun die Gesundheitssysteme der USA und
10 weiterer reicher Länder verglichen und die wichtigsten Kostentreiber identifiziert.
Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats
Authors: Busari Abdulwasiu , Adejare Abdullahi , Shodipe Abiodun , Oduniyi Oludaisi , Ismail-Badmus Khadijah , Oreagba Ibrahim 
Published: June 2018

Abstract
Background Cisplatin is an anti-cancer drug that causes nephrotoxicity and oxidative stress. Extracts of Nigella sativa is nephroprotective. Vitamin E is also a potent antioxidant. This study sought to determine a possible synergistic effect of administering the two agents prior to cisplatin use on nephrotoxicity and oxidative stress.
Methods 48 male Wistar rats were randomly divided into 6 groups of 8 rats each. Group I served as the control. Group II received cisplatin without any treatment for 6 days. Groups III, IV, V and VI received 100 mg/kg Nigella sativa (NS), 200 mg/kg NS, 100 mg/kg Vitamin E and 200 mg/kg NS+100 mg/kg Vitamin E respectively for 5 days prior to 6 days administration of cisplatin. On the last day of the experiment, all the animals were sacrificed and serum samples collected for analysis.
Results Cisplatin administration caused a significant increase in creatinine level (p<0.01), urea level (p<0.01), sodium concentration and malondialdehyde level (p<0.001). Pre-administration with NS caused a significant reduction in creatinine level (p<0.001), urea level (p<0.001), sodium concentration (p<0.001) and malondialdehyde (p<0.01) level. Pre-administration with vitamin E caused a significant reduction in creatinine level (p<0.001), urea level (p<0.01), sodium concentration (p<0.001) and malondialdehyde level. They both also caused a significant increase in superoxide dismutase, reduced glutathione and catalase (CAT) levels. The combination of NS and vitamin E however did not show significant synergistic effects.
Conclusion These results suggest that even though pre-administration of the two agents protect against renal toxicity and oxidative stress, the effects are however not collaborative.
Training Performed Above Lactate Threshold Decreases p53 and Shelterin Expression in Mice
Authors: de Carvalho Cunha Verusca , dos Santos Rosa Thiago , Sales Marcelo , Sousa Caio , da Silva Aguiar Samuel , Deus Lysleine , Simoes Herbert , de Andrade Rosangela 
Published: June 2018

AbstractTelomere shortening is associated to sarcopenia leading to functional impairment during aging. There are mechanisms associated with telomere attrition, as well to its protection and repair. Physical training is a factor that attenuates telomere shortening, but little is known about the effects of different exercise intensities on telomere biology. Thus, we evaluated the effects of exercise intensity (moderate vs. high-intensity domain) on gene expression of senescence markers Checkpoint kinase 2 and tumor suppressor (Chk2 and p53, respectively), shelterin telomere repeat binding 1 and 2 (Trf1/Trf2), DNA repair (Xrcc5), telomerase reverse transcriptase (mTERT) and telomere length in middle aged mice. Three groups were studied: a control group (CTL) and two groups submitted to swimming at intensities below the lactate threshold (LI group) and above the lactate threshold (HI group) for 40 and 20 min respectively, for 12 weeks. After training, the HI group showed reduction in p53 expression in the muscle, and decreased shelterin complex expression when compared to LI group. No differences were observed between groups for mTERT expression and telomere length. Thus, exercise training in high-intensity domain was more effective on reducing markers of senescence and apoptosis. The higher intensity exercise training also diminished shelterin expression, with no differences in telomere length and mTERT expression. Such results possibly indicate a more effective DNA protection for the higher-intensity exercise training.
The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus
Authors: Zhu Fan-Fan , Yang Li-Zhen 
Published: June 2018

Abstract
Background Type 2 diabetes has an underlying pathology with thyroid dysfunction. However, few studies have investigated the association between thyroid hormones and diabetic peripheral neuropathy. Our aim was to evaluate the relationship between thyroid hormones and electrophysiological properties of peripheral nerves in type 2 diabetes.
Patients and Methods The medical records of 308 patients with type 2 diabetes were enrolled in this study. Subjects stratified by sex were divided into subgroups based on the diagnosis of nerve conduction study. The nerve conduction parameters were separately described with the spectrum of thyroid hormones. Multivariate regression models to analyze the potential links between thyroid hormones and nerve conduction parameters.
Results The serum free triiodine thyronine levels between normal and abnormal nerve conduction groups were statistically different in total (4.55±0.65 vs 4.37±0.63, P<0.05) and female diabetic patients (4.46±0.50 vs 4.14±0.57, P<0.01). Moreover, the summed amplitude and velocity Z score of female and male increased with free triiodine thyronine levels (P<0.05). Sex-specific binary logistic regression models showed that free triiodine thyronine levels were associated with decreased odds of abnormal nerve conduction diagnosis (odds ratio [95%CI]=0.151[0.047-0.186]) and low tertile of summed amplitude Z score (odds ratio [95%CI]=0.283[0.099-0.809]) in female. In total patients, free triiodine thyronine level was negatively associated with odds of abnormal nerve conduction (odds ratio [95%CI]=0.436 [0.226-0.842]), low tertile of summed velocity (odds ratio [95%CI]=0.44[0.226-0.858]) and amplitude (odds ratio [95%CI]=0.436[0.227-0.838) Z score.
Conclusions Serum free triiodine thyronine level is associated with nerve conduction in diabetes. Low free triiodine thyronine may be a potential risk for diabetic peripheral neuropathy.
Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes
Authors: Reymond Jean-Louis , Boilevin Jérémy 
Published: June 2018

Here we review chemical and chemoenzymatic methods for the synthesis of lipid-linked oligosaccharides (LLOs) and their phosphonate analogues, which serve as substrates and inhibitors to investigate the structure and mechanism of protein N-glycosylation enzymes. We emphasize how to overcome the challenges pertaining to the instability and difficult physicochemical properties of this class of compounds.1	Introduction2	LLO Syntheses2.1	Glycosyl Phosphate Syntheses2.2	Glycosyl Phosphonates2.3	Lipid Elongation2.4	Lipid Phosphates2.5	Coupling Reaction Strategies3	Chemoenzymatic Synthesis of Elongated LLOs4	Biological Properties of Synthetic LLOs5	Conclusion