bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Risk Factors of Osteoporosis among Postmenopausal Women Visiting a District Hospital of Nepal: An Observational Study
Authors: Pandey Dipendra , Basnet Samina , Pradhananga Smeena , Shrestha Sarita , Rijal Badri , Neupane Aman , Timilsina Utsav , Upreti Amit , Upreti Apil , Baskota Rabindra , Hamal Pawan Kumar 
Published: November 2024

Introduction: Osteoporosis and low bone mass affect millions of people worldwide, leading to severe consequences ranging from disability to mortality. This study aimed to determine the prevalence and risk factors of osteoporosis among postmenopausal women in a district of Nepal.Methods: An analytical cross-sectional study involving postmenopausal women from Nuwakot, Dhading, and Rasuwa districts in Nepal was conducted at Trishuli Hospital, Nuwakot. Ethical approval was taken from the Institutional Review Board of Nepal Health Research Council(Reference number: 1768). The prevalence of osteoporosis was determined, and the associated factors were analyzed using multivariate logistic regression. Dual-Energy X-ray Absorptiometry (GE-Lunar Prodigy) was used to measure Bone Mineral Density (g/cm2) at the proximal femur and lumbar spine. Various factors related to osteoporosis were also analyzed.Results: There were 384 postmenopausal women and the prevalence of osteoporosis was 82 (21.35%; 95% CI: 17.25%-25.45%)e. The mean age of female with osteoporosis was 67.52±8.84 years and that without osteoporosis was 55.70±7.69 years (p <0.001). The multivariate logistic regression showed aOR 0.82 for body mass index.Conclusions: The study reports a lower prevalence of osteoporosis than expected in postmenopausal women. There was a significant inverse relationship between osteoporosis and body mass index. However, no significant association was observed between Bone Mineral Density, biochemical variables, smoking, and parity.
Aplikasi Peran Pendidikan Etika Politik Pada Fenomena Politik Identitas di Pemilu 2024
Authors: Maruapey Husein , Andani Herli , Nursahwa Shifa , Sa’diah Halimatu , Paujiah Nur Santi 
Published: November 2024

Indonesia merupakan negara luas dengan banyaknya jumlah penduduk, memiliki 17.001 pulau yang tersebar di seluruh wilayah Indonesia yang sangat beragam etnis, bahasa, dan agama. Dari sisi keragaman ini, politik identitas sering muncul pada sejarah modern Indonesia. Pemilu 2024 di Indonesia di hadapkan pada tantangan yang kompleks, salah satunya adalah politik identitas yang saat ini mempengaruhi berjalannya proses demokrasi. Politik identitas merupakan kegiatan politik yang berdasarkan identitas individu baik dari etnis,ras, suku dan agama. Politik identitas seharusnya dapat menggabungkan antara politik kebangsaan yang dimana tidak lagi memprioritaskan kepentingan kelompok-kelompok tertentu. Dampak yang dapat di munculkan dari politik identitas yaitu dapat menyerang golongan tertentu yang menimbulkan diskriminasi hingga radikalisasi. Agar tidak terjadi kejadian yang tidak diinginkan, sebagai masyarakat Indonesia kita harus pintar dalam menyikapi setiap berita yang ada tentang pemilu. Indonesia memiliki banyak keberagaman, tetapi dari banyaknya keberagaman tersebut bisa menghasilkan berbagai pemikiran baik yang benar maupun buruk. Agar menjadi warga negara yang baik kita harus menyaring segala berita yang ada, untuk terhindar dari politik identitas yang bersifat diskriminasi hingga radikalisasi. Metode dalam penulisan artikel ini yaitu studi literatur dengan mengumpulkan beberapa jurnal lalu diteliti dan diolah sehingga menjadi tulisan artikel. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh politik identitas terhadap pemilu 2024, membangun sistem demokrasi yang murni tanpa adanya diskriminasi, calon pemimpin mempunyai visi dan misi dalam membangun kemajuan bangsa, memberikan kesempatan kepada rakyat untuk berpendapat maupun mengkritik pemerintah adalah cara untuk kemajuan demokrasi yang terbuka. Hasil dari penelitian ini dapat dilihat dari analisis yang telah penulis sampaikan menunjukan bahwa politik identitas memiliki pengaruh yang signifikan terhadap berlangsungnya pemilu.
Pengembangan Media Spinning Wheel Pada Materi Lambang Bilangan
Authors: Tuzzahra Lega Zulfi Fatma , Airlanda Gamaliel Septian 
Published: November 2024

Dunia anak adalah dunia bermain, hal ini merupakan kebutuhan primer yang sulit dipisahkan dari kehidupan mereka. Penelitian ini bertujuan untuk mengembangkan media permainan Spinning Wheel agar tercipta pembelajaran berbasis learn and play juga meningkatkan motivasi belajar siswa kelas III Sekolah Dasar pada materi lambang bilangan. Penelitian ini dilaksanakan di SD Negeri 1 Panimbo. Penelitian ini merupakan penelitian pengembangan (R & D) oleh Borg dan Gall yang dimodifikasi oleh Sukmadinata. Penulis menyesuaikan model penelitian dan pengembangan Sukmadinata dengan menggunakan model pengembangan ADDIE (Analysis, Design, Development, Implementation & Evaluation). Teknik analisis data yang digunakan pada penelitian ini adalah analisis data kuantitatif dan deskriptif. Instrumen yang digunakan pada penelitian ini adalah lembar yang berisi butiran pernyataan. Dari penelitian yang dilakukan diperoleh hasil uji validasi oleh ahli media diperoleh skor sebesar 89%, oleh ahli materi diperoleh skor 93%, dan oleh ahli desain pembelajaran diperoleh skor 79%. Hasil angket respon siswa diperoleh presentase sebesar 85,185%, Rata-rata nilai pretest yang diperoleh siswa yaitu 39.26 dan nilai posttest diperoleh 84.44. Dari hasil tersebut, maka dapat disimpulkan bahwa hasil presentase uji validasi masuk dalam kategori “Sangat Tinggi” dan hasil presentase respon siswa masuk dalam kategori “sangat menarik” sehingga pemahaman peserta didik dalam memahami materi pembelajaran sebelum dan sesudah menggunkan media pembelajaran Spinning Wheel terdapat peningkatan yang signifikan.
Analisis Kesalahan Penggunaan Kata Baku dalam Karangan Eksposisi Siswa Sekolah Dasar
Authors: Salim Salim , Indriyanto Kristiawan , Sari Sartika 
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan bentuk-bentuk kesalahan berbahasa bidang morfologi pada karangan eksposisi siswa Kelas VI SD Negeri 1 Blangkajeren, Kabupaten Gayo Lues. Data penelitian ini berupa karangan eksposisi siswa sebanyak 30 karangan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Setelah data terkumpul dilakukan analisis kemudian dideskripsikan dalam bentuk tulisan. Teknik analisis data yang digunakan adalah teknik tes, yakni siswa diminta untuk menulis karangan eksposisi. Hasil penelitian ini menunjukkan bahwa dari 30 karangan eksposisi terdapat sejumlah kesalahan morfologi dalam karangan eksposisi siswa yakni kesalahan dalam afiksasi, kesalahan kompositum, kesalahan reduplikasi, kesalahan penggunaan kata baku/ tidak baku, dan kesalahan karena adanya interfrensi bahasa Gayo terhadap bahasa Indonesia dalam karangan eksposisi siswa.
Analisis Kesalahan Pada Kemampuan Menulis Permulaan Peserta Didik Sekolah Dasar
Authors: Oktaviana Putri , Karma I Nyoman , Nurwahidah Nurwahidah 
Published: November 2024

Kesalahan pada kemampuan menulis adalah kesalahan atau kekeliruan dalam berbahasa berakibat karena penutur tidak tepat dalam memilih kata atau ungkapan untuk situasi tertentu. Penelitian ini bertujuan untuk mengetahui kesalahan menulis pada kemampuan peserta didik di kelas II SDN 40 Mataram. Jenis penelitian yang digunakan adalah deskriptif kualitatif. subyek penelitian ini adalah peserta didik di kelas II SDN 40 Mataram dengan jumlah peserta didik 25 peserta didik yg terdiri dari 13 orang laki-laki dan dan 12 orang perempuan. Teknik pengumpulan data yang dilakukan dalam penelitian ini adalah tes tulis, observasi, dan dokumentasi. Penelitian ini berfokus pada penggunaan huruf capital, penggunaan tanda baca, dan penulisan kata ejaan. Teknik analisis data menggunakan teknik pengumpulan data, reduksi data, penyajian data, dan pengambilan kesimpulan. Uji keabsahan data dilakukan dengan menggunakan tringulasi sumber dan tringulasi teknik pengumpulan data. Hasil penelitian menunjukan presentase kesalahan peserta didik dalam kemampuan menulis pada teks cerita dongeng yaitu kesalahan penulisan kata ejaan sebanyak 53 kesalahan dengan persentase 23,98%, kesalahan penulisan huruf kapital sebanyak 90 kesalahan dengan persentase 40,72%, dan kesalahan penggunaan tanda baca 78 kesalahan dengan persentase 35,29%. Hal ini menunjukan bahwa kesalahan pada kemampuan menulis permulaan peserta didik perlu ditingkatkan.
A materialização da consciência e a defesa da fenomenologia transcendental em Husserl
Authors: Carvalho Guilherme Felipe , Ferraguto Federico 
Published: November 2024

O presente artigo pretende discutir a defesa que Husserl faz da fenomenologia transcendental diante da atitude de materialização e da naturalização da consciência, que domina na atitude que está na base da formação das ciências naturais. Herdando certos elementos da Filosofia Clássica Alemã, Husserl compreende que é somente por meio do a priori que a filosofia pode ser efetivada como ciência rigorosa. A análise se desenvolverá, inicialmente, por meio da discussão crítica do problema que Husserl indica haver nas ciências baseadas na atitude natural, ou seja, a materialização da consciência. Em seguida, mostraremos como diante do projeto de construção de uma filosofia como ciência rigorosa, o naturalismo, ingênuo em sua fundamentação, é o principal obstáculo a ser superado por conta das consequências que dele podem surgir, implicando em correntes como o psicologismo, materialismo e positivismo. Por fim, apontaremos a maneira como Husserl faz uma defesa da fenomenologia transcendental contra a ingenuidade da ciência natural que permanece presa nos fatos empíricos e faz destes o critério último de atestação da verdade.
THE EFFECT OF SERVICE QUALITY AND REPUTATION ON PATIENT LOYALTY AT POLY ORAL SURGERY
Authors: Fratiwi Winda 
Published: November 2024

Background : Hospital is one of the health service facilities. Hospitals need to maintain the quality of their services, this health service is always required to always improve. The higher the quality of service will affect patient loyalty. The purpose of the research : to determine the effect of service quality and reputation on the loyalty of oral surgery poly patients at the Rumah Sakit Umum Daerah dr. Soekardjo Kota Tasikmalaya. Research method : the method used in this study is explanatory survey. How to test the effect of health care quality and reputation on patient loyalty with statistical tests path a nalyysis. The sample in this study was 63 oral surgery poly patients in Rumah Sakit Umum Daerah dr.Soekardjo Kota Tasikmalaya City. The results of the study : the calculation of the value of the variable path coefficients (X 1), and (X2) against (Y), P YX1 is 0.439 and P YX2 is 0.417. Conclusion : quality of service and reputation affect thequality of oral surgery poly patients in Rumah Sakit Umum Daerah dr.Soekardjo Kota Tasikmalaya.
STRATEGI KOMUNIKASI PEMASARAN DALAM MENINGKATKAN KUNJUNGAN WISATAWAN DI DESA WISATA CIKOLELET
Authors: Pitasari Dwi Nurina , Nurul Aulia Dewi  
Published: November 2024

Desa Wisata Cikolelet merupakan desa wisata yang meraih dua penghargaan pada acara ADWI tahun 2021 dan pioner ndesa wisata di kabupaten Serang. Banyaknya desa wisata yang bermunculan membuat desa wisata ini harus membuat strategi komunikasi yang baik agar mampu bersaing. Tujuan penelitian ini untuk mengetahui strategi komunikasi pemasaran yang dilakukan oleh pengelola Desa Wisata Cikolelet dalam meningkatkan kunjungan wisatawan. Pendekatan yang digunakan adalah pendekatan deskriptif kualitatif dan metode yang digunakan dalam penelitian ini adalah case study atau studi kasus. Strategi komunikasi pemasaran yang dilakukan Pokdarwis Cikolelet dianalisis menggunakan model AIDDA. Pada tahap awareness, desa wisata ini memperkenalkan melalui media sosial untuk menarik minat wisatawan. Selanjutnya adanya rasa ketertarikan (interest) wisatawan dapat mencari informasi dan mempelajari lebih lanjut mengenai desa wisata. Kemudian setelah wisatawan tertarik, akan muncul keinginan (desire) untuk berkunjung ke desa wisata ini. Setelah adanya keinginan, maka wisatawan akan menentukan keputusan (decision) untuk berkunjung. Di tahap akhir, wisatawan akhirnya merealisasikan keputusan tersebut dengan berkunjung ke desa wisata.
Enhancing ascitic fungal infection diagnosis through next-generation sequencing: a pilot study in surgical ICU patients
Authors: Posadas-Cantera Sara , Mehrbarzin Negin , Wetzel Simon , Goelz Hanna , Kousoulas Lampros , Utzolino Stefan , Häcker Georg , Badr Mohamed Tarek 
Published: November 2024

ObjectivesAscites, often associated with critical pathologies such as liver cirrhosis or bowel perforation, can be complicated by fungal infection, increasing mortality especially in intensive care settings and demanding rapid diagnosis and adequate treatment. Traditional microbiological diagnostic methods have limited sensitivity in accurately identifying fungal pathogens in ascitic fluid. Alternative diagnostic methods may offer important insights to enable guiding of antifungal therapy and refining empirical treatment strategies. The objective of this study was to evaluate the potential of next-generation sequencing methods to identify specific fungal pathogens responsible for ascitic fluid infections.MethodsWe prospectively collected 50 ascitic fluid samples from ICU patients with suspected ascites infection. In addition to standard culture-based microbiological testing, an ascitic fluid aliquot underwent fungal DNA isolation and was analyzed by next-generation sequencing (NGS) methods for identification of fungal species.ResultsOf 50 ascitic samples collected, five samples showed growth of Candida spp. in culture. After DNA isolation and ITS2 PCR, detectable amplification was achieved in 10 samples. Sequencing of the 50 patients’ samples identified facultative pathogenic fungi in 19 patients. In 15 cases, culture alone would not have permitted the identification of all facultative pathogenic fungi. The identification of fungal DNA by sequencing was significantly associated with poor patient outcome and a number of clinical parameters.ConclusionsOur results show a higher sensitivity for NGS-based diagnostic methods in the identification of ascitic fluid fungal infections compared to culture-based diagnostics. This may be beneficial especially for patients in a critical care setting, who have an increased prevalence of comorbidities and high mortality. The implementation of such methods in standard diagnosis will require increased standardization of the workflows and interpretation of the sequencing results with respect to patients’ clinical picture.
Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus
Authors: Yao Lili , Xu Jie , Zhang Xu , Tang Zhuqi , Chen Yuqing , Liu Xiaoyu , Duan Xuchu 
Published: November 2024

IntroductionEndoplasmic reticulum stress (ERS) is a prominent etiological factor in the pathogenesis of diabetes. Nevertheless, the mechanisms through which ERS contributes to the development of diabetes remain elusive.MethodsTranscriptional expression profiles from the Gene Expression Omnibus (GEO) datasets were analyzed and compared to obtain the differentially expressed genes (DEGs) in T2DM. Following the intersection with ERS associated genes, the ERS related T2DM DEGs were identified. Receiver operating characteristic (ROC) and Least Absolute Shrinkage and Selection Operator (LASSO) analysis were performed to screen out the ERS related biomarker genes and validate their diagnostic values. Gene expression level was detected by qPCR and Elisa assays in diabetic mice and patient serum samples.ResultsBy analyzing the transcriptional expression profiles of the GEO datasets, 49 T2DM-related DEGs were screened out in diabetic islets. RTN1, CLGN, PCSK1, IAPP, ILF2, IMPA1, CCDC47, and PTGES3 were identified as ERS-related DEGs in T2DM, which were revealed to be involved in protein folding, membrane composition, and metabolism regulation. ROC and LASSO analysis further screened out CLGN, ILF2, and IMPA1 as biomarker genes with high value and reliability for diagnostic purposes. These three genes were then demonstrated to be targeted by the transcription factors and miRNAs, including CEBPA, CEBPB, miR-197-5p, miR-6133, and others. Among these miRNAs, the expression of miR-197-5p, miR-320c, miR-1296-3P and miR-6133 was down-regulated, while that of miR-4462, miR-4476-5P and miR-7851-3P was up-regulated in diabetic samples. Small molecular drugs, including D002994, D001564, and others, were predicted to target these genes potentially. qPCR and Elisa analysis both validated the same expression alteration trend of the ERS-related biomarker genes in diabetic mice and T2DM patients.DiscussionThese findings will offer innovative perspectives for clinical diagnosis and treatment strategies for T2DM.
Prediction of the risk of mortality in older patients with coronavirus disease 2019 using blood markers and machine learning
Authors: Zhu Linchao , Yao Yimin 
Published: November 2024

IntroductionThe mortality rate among older people infected with severe acute respiratory syndrome coronavirus 2 is alarmingly high. This study aimed to explore the predictive value of a novel model for assessing the risk of death in this vulnerable cohort.MethodsWe enrolled 199 older patients with coronavirus disease 2019 (COVID-19) from Zhejiang Provincial Hospital of Chinese Medicine (Hubin) between 16 December 2022 and 17 January 2023. Additionally, 90 patients from two other centers (Qiantang and Xixi) formed an external independent testing cohort. Univariate and multivariate analyses were used to identify the risk factors for mortality. Least absolute shrinkage and selection operator (LASSO) regression analysis was used to select variables associated with COVID-19 mortality. Nine machine-learning algorithms were used to predict mortality risk in older patients, and their performance was assessed using receiver operating characteristic curves, area under the curve (AUC), calibration curve analysis, and decision curve analysis.ResultsNeutrophil–monocyte ratio, neutrophil–lymphocyte ratio, C‐ reactive protein, interleukin 6, and D-dimer were considered to be relevant factors associated with the death risk of COVID-19-related death by LASSO regression. The Gaussian naive Bayes model was the best-performing model. In the validation cohort, the model had an AUC of 0.901, whereas in the testing cohort, the model had an AUC of 0.952. The calibration curve showed a good correlation between the actual and predicted probabilities, and the decision curve indicated a strong clinical benefit. Furthermore, the model had an AUC of 0.873 in an external independent testing cohort.DiscussionIn this study, a predictive machine-learning model was developed with an online prediction tool designed to assist clinicians in evaluating mortality risk factors and devising targeted and effective treatments for older patients with COVID-19, potentially reducing the mortality rates.
NFIL3/Tim3 axis regulates effector Th1 inflammation in COPD mice
Authors: Ke Junyi , Huang Shu , He Zhixiong , Lei Siyu , Lin Shiya , Li Yinying , Li Qiuming , Huang Hui , Huang Hongchun , Qin Huajiao , Duan Minchao 
Published: November 2024

BackgroundIFN-γ+CD4+ cells (type 1 helper T cells, Th1) represent a critical component of the inflammatory environment in the lungs of chronic obstructive pulmonary disease (COPD). Identifying influencing factors related to COPD-associated Th1 cells will enhance our understanding of the inflammatory mechanisms involved and facilitate the development of targeted interventions.MethodWe describe T-cell immunoglobulin and mucin-domain containing-3 (Tim3) as a key gene regulating COPD-associated Th1 cells through single-cell sequencing, flow cytometry and knockout mice.ResultsOur findings indicate that Havcr2 expression gradually increases during CD4+ T cell activation in COPD mice, with Tim3 being highly expressed on both CD4+ T cells and Th1 cells. Notably, the knockout of HAVCR2 further promotes the infiltration of CD4+ T cells and the expression of IFN-γ in the lungs, resulting in a more severe emphysema phenotype, although it does not significantly affect TNF-α expression. Additionally, NFIL3, an upstream regulator of Tim3, is also highly expressed in the CD4+ T cells of COPD mice. Mice with NFIL3 knockout exhibit phenotypes similar to those of HAVCR2 knockout mice, along with a significant downregulation of Tim3 expression. In vitro, we simulated the activation process by polarizing primary CD4+ Tn cells from COPD mice and observed that NFIL3/Tim3 expression was significantly upregulated following Th1 polarization.ConclusionOur study demonstrates that the NFIL3/Tim3 axis plays a role in Th1 imbalance in the lungs of COPD by inhibiting Th1 differentiation.
Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in the treatment of advanced colorectal cancer: a systematic review and meta-analysis
Authors: Song Dandan , Hou Shufu , Ma Ning , Yan Bing , Gao Jing 
Published: November 2024

BackgroundThe efficacy and safety of PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors in the treatment of advanced colorectal cancer is controversial. This meta-analysis aimed to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors for advanced colorectal cancer.MethodsPubMed, Embase, the Cochrane Library, and Web of Science databases were systematically searched for relevant studies. Outcomes including median progression-free survival (mPFS), median overall survival (mOS), overall response rate (ORR), disease control rate (DCR), treatment-related adverse events (TRAEs) and ≥grade 3 TRAEs were extracted for further analysis. The risk of bias was assessed by subgroup analysis.Results12 articles with 566 patients were identified and subjected to meta-analysis. With regard to survival analysis, the pooled mOS and mPFS were 6.66 months (95%CI 4.85-9.16) and 2.92 months (95%CI 2.23-3.83), respectively. In terms of tumor response, the pooled ORR and DCR were 21% (95%CI 6%-41%) and 49% (95%CI 27%-71%), respectively. The pooled AEs rate and ≥ grade 3 AEs rate were 94% (95%CI 86%-99%) and 44% (95%CI 30%-58%).ConclusionPD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors have shown promising clinical responses in the treatment of colorectal cancer (CRC). Although the incidence of adverse reactions is high, they are generally tolerable.Systematic review registrationhttps://inplasy.com/, identifier INPLASY202480030.