bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Partnership Between a Rural Mental Health Center and Community Pharmacy: Integration of a Mental Health Pharmacist
Authors: Ng ShuYing , Jones Robert Buckner , Schwartzwald Laura , Murugappan Meena , Pittenger Amy , Edwards Kevin , Seifert Randall 
Published: June 2019

Purpose: The purpose of this article is to describe how an innovative partnership between a rural community mental health center, community independent pharmacy and College of Pharmacy and integration of a mental health pharmacist lead to identification of medication therapy problems (MTP’s) and interprofessional team partnerships with center mental health professionals.
Methods: A contractual arrangement was initiated between Northern Pines Mental Health Center (NPMHC), GuidePoint Pharmacy Services GPS) and the University of Minnesota College of Pharmacy (UMN CoP) to place a PGY1 resident at NPMHC. The resident was assigned to work closely with the Chief Medical Officer and provide initial comprehensive medication management (CMM) services to individuals who were enrolled in Assertive Community Treatment (ACT). A retrospective chart review was conducted to evaluate the impact of services provided. Patient inclusion criteria included ACT enrollees 18 years or older, a diagnosis of SPMI, taking at least one psychotropic medication, and participation in at least one resident-led CMM visit. Additional findings included the relationship between the pharmacist, the psychiatric physician, and other members of the ACT team. Descriptive statistics were used to document the findings.
Findings: N = 30 met the inclusion criteria: 18 males and 12 females, age ranged from 24 - 69 with average of 44 years old. 110 MTPs were identified ranging from no MTPs to 10 MTPs per patient, with a mean of 4 MTPs/patient. There was an uneven distribution of MTPs between psychiatric and medical conditions, with a disproportionately high occurrence of “Needs Additional Drug Therapy” in medical conditions and “Adverse Drug Reaction” in psychiatric conditions. In addition, the services were valued by members on the ACT team.
Conclusion: Rural residents with SPMI in intensive community treatment have complex medication needs that require the training and skills of a clinical pharmacist. Despite the inclusion of a medication list as part of the ACT fidelity standards MTPs may go unrecognized and unresolved without the services of a clinical pharmacist conducting CMM. The pharmacist and psychiatric physician formed a collaborative partnership to address medication issues. We conclude that there is a need for integrating clinical pharmacist services into rural mental health centers.

Article Type: Original Research
Ohio Community Pharmacist Interest and Participation in Community-Clinical Linkages
Authors: Alexander Scott J , DiPietro Mager Natalie A 
Published: June 2019

Background: Community-clinical linkages have been promoted as a means to improve population health. The community pharmacy is an ideal location for these partnerships to occur due to the expertise of the community pharmacist. While the need for these partnerships exists, there are limited data regarding community pharmacists’ current participation in such programs.
Objective: The purpose of this analysis was to assess Ohio community pharmacists’ involvement and interest in community-clinical linkages.
Methods: An electronic survey tool containing 26 questions was developed to assess Ohio community pharmacists’ participation in community-clinical linkages and interest to develop such partnerships. The tool was sent via email to a random sample of 500 pharmacists registered in Ohio and practicing in a community setting. Chi-square or Fisher exact nonparametric statistical tests were used as appropriate to identify whether there were any significant differences in current partnership or interest to partner with a prescriber who refers patients to their community pharmacy based on education (Bachelor of Science or Doctor of Pharmacy degree) or pharmacy location (urban, suburban, or rural).
Results: Nine emails were undeliverable, leaving a sample of 491 pharmacists. Ninety-three (19%) responded to the survey. Sixteen respondents (17%) indicated that they currently partner with a prescriber who refers patients to their pharmacy for assistance with medications or chronic disease state management; this practice was more often reported in urban settings (p=0.022). Of those not currently participating in such a partnership, 53 (57%) were interested in developing one. Thirty-two respondents (34%) reported providing referrals for at least 1 type of screening or counseling service. For some types of services, pharmacists reported that they provide the service in the pharmacy and/or were interested to develop the service in the pharmacy rather than provide a referral. However, for any given service there were a number of pharmacists who expressed interest in providing referrals although they were not currently doing so.
Conclusion: This sample of Ohio community pharmacists reported limited participation in community-clinical linkages but interest to develop them. Further studies should explore the pharmacists’ role and impact in such programs.

Article Type: Original Research
40Ar/39Ar age of rock deformations across the Bazhenov suture zone (eastern border of the Middle Urals)
Authors: Smirnov V. N. , Ivanov K. S. , Travin A. V. 
Published: June 2019

Research subject. This article presents data on the nature of rock deformations in the Bazhenov suture zone. The data was obtained by 40Ar/39Ar dating of mica samples from schists and blastomylonites, which were collected acrossan area extending approximately for 100 km along the Bazhenov suture. This suture separates the Eastern zone of the Middle Urals dipped under the cover of the West Siberian plate from exposed geologic structures of the Urals.Methods.The character of the deformations was studied by means of direct geological observation. The age of the deformations was determined by mica dating using the 40Ar/39Ar method.Results. The deformations were found to have occurred in several phases. The initial phase, which led to the formation of a band of blastomylonites and rocks showing a varying degree of schistosity with a width of over 10 km in particular areas, is likely to have had the character of left-lateral fault. The upper age limit of this deformation phase is determined by the intrusion of the subalkaline rocks of the Petukhovskii complex (280 Ma), which had not been affected by any deformation processes. The subsequent type of deformations had been left-lateral strike-slip faults of submeridianal strike and subvertical dip, which were represented by low-thickness (usually about 10 cm, rarely up to 0.5 m) zones of intensely deformed rocks cutting the schistosity of the previous phase at an acute angle. The final phase of the deformations is shown to be a sloping fault. The dislocation planes of this type were represented by slickensides and chlorite incrustations. Despite the apparent polychronicity of the deformation processes, which were established within the Bazhenov suture zone by our geological observations, 40Ar/39Ar age dating identified only one event. The average value of five conducted tests was about 251 Ma. Apparently, this age should be associated with the most recent geological processes having occurred at temperatures sufficient to fully overload the K-Ar isotopic system of the studied rocks, such as the deformations caused by strike-slip dislocations.Conclusions. The strike-slip fault dislocations dated in this work occurred approximately 25 Ma after the completion of the tectonic activity in the Serov-Mauk fault zone, which is located to the west of the Bazhenov zone. In addition, the time of these dislocations very nearly coincides with that of the formation of the grabens of meridional strike at the base of the West Siberian plate, which took place about 250 Ma ago. This supports apreviously made conclusionon the similar character of the geological development of the eastern border part of the Urals and the adjoining basement of the West Siberian plate.
Trace-elements in minerals from unusual rocks of the Southern Urals
Authors: Korinevsky V. G. , Filippova K. A. , Kotlyarov V. A. , Korinevsky E. V. , Artemyev D. A. 
Published: June 2019

Research subject. This articles presents the data obtained in the course of 75 analytical studies on a wide range of minerals (amphiboles, pyroxenes, garnets, spinels, olivines, anorthites, corundums, epidotes, apatites, clinochlore, dolomite, calcite, zircon) contained in igneous and metamorphic Southern Urals rocks. In addition, information is provided about the content of trace elements, including rare earth (REE) ones, in these rocks. The data on the content of trace elements in some minerals are presented for the first time (höegbomite, sapphirine, zoisite, clinozoisite, gedrite, cummingtonite, anthophyllite, potassium-magnesiohastingsite). Materials and methods. A petrographic analysis of rocks containing the minerals under study was carried out. A particular attention was paid to petrographic analysis of rocks containing the minerals under study was carried out. A particular attention was paid to “fresh” rocks, containing the mineral under study which rarely occur in the Urals. These rocks feature inclusions of serpentinite melange in the form of plates and lenses among the metamorphic strata (schists, gneisses, and amphibolites) and are characterized by the preservation of primary structures, relative chemical homogeneity, as well as the presence of simultaneous growth surfaces between most minerals. Of particular research interest were minerals from rocks, the composition of which had been relatively poorly studied (pyroxene-amphibole anorthite gabbro and gabbro-amphibolites, scapolite rocks, hornblendite, gedrite-cummingtonite-anthophyllitic crystallo-schists and amphibolites, ore-less carbonatites). The composition of mineral samples was determined using a scanning microscope REMMA-202 M equipped with an energy dispersive console and a mass-spectrometer Agilent 7700x (ICP-MS and LA-ICP-MS methods). Results. Petrographic characteristics of the rocks containing the minerals under study are given. The geographical coordinates of locations, where mineral sampling was performed, are provided. The content of trace elements is shown to vary greatly within related species of minerals (amphiboles, garnets, pyroxenes, olivines, epidotes, spinels, mica, etc.), with the fluctuations being independent of the alkalinity of host rocks or their geological nature.Conclusions. For the first time, a significant role of zoisite and clinozoisite in the process of concentrating trace elements, including REE, has been revealed. The role of apatite as one of the main mineral concentrators of REE has not been confirmed either in the main and ultrabasic rocks, or in some calcite-dolomite carbonatites.
Determination and evaluation of minimum miscibility pressure using various methods: experimental, visual observation, and simulation
Authors: Abdurrahman Muslim , Bae Wisup , Permadi Asep Kurnia 
Published: June 2019

This research proposes a simultaneous technique using various methods to yield the most reliable Minimum Miscibility Pressure (MMP) value. Several methods have been utilized in this study including slim tube test, swelling test, vanishing interfacial tension test, visual observation during swelling test and vanishing interfacial tension test, and simulation. The proposed method may reduce the uncertainty and avoid doubtful MMP. The method can also demonstrate discrepancies among the results. There were two samples used in this study namely Crude Oil AB-5 and Crude Oil AB-4. It showed that for Crude Oil AB-5 the discrepancies among the results from that of the slim tube test were between 3.9% and 10.4% and 0% and 5.9% for the temperature of 60 °C and 66 °C, respectively. The highest discrepancy was shown by the results from the visual observation during vanishing interfacial tension test and the lowest discrepancy was shown by the results from the swelling test. The vanishing interfacial tension test was found to be the fastest method for predicting the MMP. The method also consumed a smaller amount of oil and gas samples for the experiment. The simultaneous method proposed in this study is considered as more proper and exhibits a valuable method for predicting the MMP. This technique has never been found to be performed by previous researchers and accordingly it becomes the strong point of this study to contribute to the global research in the area of MMP determination.
ESTUDO DA PRÉ-VIABILIDADE TÉCNICO-FINANCEIRA DOS PROCESSOS DE PRODUÇÃO DOS AMINOÁCIDOS TREONINA E TRIPTOFANO
Authors: Rodrigues Debora Leite da Rocha , Piccoli Rosane A. M. 
Published: June 2019

A treonina e o triptofano são aminoácidos essenciais para o desenvolvimento humano e animal. Em 2012 o Brasil importou 21.000 toneladas de treonina e 3.400 toneladas de triptofano para consumo interno. O BNDES emitiu um relatório e sugeriu a substituição da importação por produção local destes aminoácidos. Uma vez que a treonina e o triptofano são produzidos por via biotecnológica e portanto podem ser sintetizados a partir da sacarose, existe grande possibilidade de realizar essa produção no Brasil. A partir dessa ideia foi realizada a análise do custo de produção da treonina e do triptofano empregando o software Superpro Designer utilizando dados da literatura como parâmetros para a simulação. Obteve-se através da simulação o custo de produção para a treonina de US$1,67/kg e, para a produção de triptofano de U$3,75/kg, sendo considerados custos viáveis comparados ao preço FOB de mercado: treonina US$2,10/kg a US$2,80/kg e triptofano de US$6/kg a US$20/kg.
Adaptações tecnológicas para alunos com necessidades educativas especiais
Authors: Antón Ares Paloma 
Published: June 2019

As inovações tecnológicas facilitam a comunicação, conectando as pessoas com os parceiros de um extremo a outro do planeta. Esta realidade oferece possibilidades que nos levam à adoção de novos padrões de colaboração em ambientes de ensino, pesquisa ou de interação social. Aliado a isso, é necessário atentar para o fato de que a tecnologia pode se tornar uma ferramenta pedagógica de formação e integração, mas, ao mesmo tempo, corre risco de ser um elemento de exclusão de um importante grupo: as pessoas que, por várias razões, têm necessidades diferentes de usá-los. Para evitar que isso aconteça, deve-se defender um design acessível e unir esforços para informar, educar e investigar, a fim de dispor de recursos que permitam e incentivem o uso das tecnologias da informação e comunicação por pessoas com deficiência ou capacidades diferenciadas.
COMPARISON OF MUTANT P53 PROTEIN EXPRESSION IN PTERYGIUM GROUP WITH AND WITHOUT TRIAMCINOLONE ACETONITED INJECTION
Authors: Erna Riani 
Published: June 2019

Background: Mutant p53 protein is produced by mutant p53 gene, this protein takes part in tissue hyperplasia process in pterygium. Triamcinolone acetonide in often use to reduce reccurency. Besides decreasing the inflamation triamcinolone acetonide is assumed to be able to repair the function of p53 gene. Thus, it reactivates cell apoptosis system and prevent the tissue hyperplasia process in pterygium.To compare Mutant p53 Protein Expression in Pterygium Group With and Without Triamcinolone Acetonide InjectionMethods: This research is a randomized clinical trial study consists of 31 subject who suffered primary pterygium. All subject divided into 2 grup with and without triamcinolone acetonide injection. After excision the pterygium and the tissue were examined through histopatology and immunohistochemical with Hematcoycline Eosin and reagent Clone DO7 staining to see the mutant p53 protein expression.Results: Mutant p53 protein expression in triamcinolone acetonite injected group is 0% and non triamcinolone acetonite injected group is 33,33%Conclusion: Mutant p53 protein expression in triamconolone acetonite injected group is lower than non injected grou.
Keywords: Mutant p53 protein, primary pterygium, triamcinolone acetonide immunohistochemicial
Peramalan Tingkat Permintaan LPG PT. Pertamina (Persero) Di Elpiji Tandem
Authors: Wijono Joko , Siregar Ninny , Banjarnahor M 
Published: June 2019

<h1>LPG that produced by PT. Pertamina (Persero) unit Pengolahan I Pangkalan Brandan cames from natural gas. LPG usually used by people for industry and home needs. Most of high-end community prefer to consume to fuel oil, outfil legible job decay (durable) bat need big investment(because the storages of LPG or LPG bottle is expensive). Most of LPG consumption for north sumatera consumer supplied by PT. Pertamina (Persero) Unit Pengolahan I Pangkalan Berandan. For maintaining LPG continuity, so demand forecasting is a neccessary for the future. Considering the decline of LPG production, which caused by natural trend linier gas reserver. To predict the demand in the demand in the future, it can count using and Exponential Smoothing forecasting method. Exponential Smoothing forecasting method that used is double Exponential Smoothing forecasting method and then parameter estimate to get the minimum (Mean Square Error). From the calculation forecasting method, Double Exponential Smoothing forecassting method can give the minimum MSE price with one parameter 0,1 and for Depot Tandem UPMS I Medan in 2010 is79.740,414 kiloliter.</h1><strong>Keywords : </strong>Eksponential Smoothing Methode<strong> </strong>, forecasting
Perencanaan Penjualan Dan Persediaan Optimal Di PT. Interyasa Sedaya Medan
Authors: Surbakti Emita Sri Ulina , Mustafa Kamil , Banjarnahor Maruli 
Published: June 2019

<h1>Based on development, the enterprise often gets problem in stock of goods, because has not planning for sales and stock of goodsfor the future accuratelly.Method which be used to determine the quantity of sales for the future is “least Square Line Method” because this method is more significance to the result that be hoped and there is also the past data quantitatively. Stock of goods are determined from the quantity of sales for the future with economic order quantity = EOQ.Based on the result of the research that has been done, where the goods that will be are television and refrigerator with the long one month. Increasing of Total sales for TV = 28.7 %. EOQ of TV = 18 units/ order and is performed 1 (one) time is week. Increasing of Total sales for refrigerator = 32.2 %. EOQ of refrigerator = 16 units/ order and is performed 1 (one) time is week.</h1>
Development and validation of the Skills Assessment in Microsurgery for Brain Aneurysms (SAMBA) instrument for predicting proficiency in aneurysm surgery
Authors: Ribeiro de Oliveira Marcelo Magaldi , Ramos Taise Mosso , Ferrarez Carlos Eduardo , Machado Carla Jorge , Vieira Costa Pollyana Helena , Alvarenga Daniel L. , Soares Carolina K. , Mainart Luiza M. , Aguilar-Salinas Pedro , Gusmão Sebastião , Sauvageau Eric , Hanel Ricardo A. , Lanzino Giuseppe 
Published: June 2019

OBJECTIVESurgical performance evaluation was first described with the OSATS (Objective Structured Assessment of Technical Skills) and modified for aneurysm microsurgery simulation with the OSAACS (Objective Structured Assessment of Aneurysm Clipping Skills). These methods rely on the subjective opinions of evaluators, however, and there is a lack of objective evaluation for proficiency in the microsurgical treatment of brain aneurysms. The authors present a new instrument, the Skill Assessment in Microsurgery for Brain Aneurysms (SAMBA) scale, which can be used similarly in a simulation model and in the treatment of unruptured middle cerebral artery (MCA) aneurysms to predict surgical performance; the authors also report on its validation.METHODSThe SAMBA scale was created by consensus among 5 vascular neurosurgeons from 2 different neurosurgical departments. SAMBA results were analyzed using descriptive statistics, Cronbach’s alpha indexes, and multivariate ANOVA analyses (p < 0.05).RESULTSExpert, intermediate-level, and novice surgeons scored, respectively, an average of 33.9, 27.1, and 16.4 points in the real surgery and 33.3, 27.3, and 19.4 points in the simulation. The SAMBA interrater reliability index was 0.995 for the real surgery and 0.996 for the simulated surgery; the intrarater reliability was 0.983 (Cronbach’s alpha). In both the simulation and the real surgery settings, the average scores achieved by members of each group (expert, intermediate level, and novice) were significantly different (p < 0.001). Scores among novice surgeons were more diverse (coefficient of variation = 12.4).CONCLUSIONSPredictive validation of the placenta brain aneurysm model has been previously reported, but the SAMBA scale adds an objective scoring system to verify microsurgical ability in this complex operation, stratifying proficiency by points. The SAMBA scale can be used as an interface between learning and practicing, as it can be applied in a safe and controlled environment, such as is provided by a placenta model, with similar results obtained in real surgery, predicting real surgical performance.
Petroclival meningiomas: long-term outcomes of multimodal treatments and management strategies based on 30 years of experience at a single institution
Authors: Kim Jin Wook , Jung Hee-Won , Kim Yong Hwy , Park Chul-Kee , Chung Hyun-Tai , Paek Sun Ha , Kim Dong Gyu , Lee Sang Hyung 
Published: June 2019

OBJECTIVEA thorough investigation of the long-term outcomes and chronological changes of multimodal treatments for petroclival meningiomas is required to establish optimal management strategies. The authors retrospectively reviewed the long-term clinical outcomes of patients with petroclival meningioma according to various treatments, including various surgical approaches, and they suggest treatment strategies based on 30 years of experience at a single institution.METHODSNinety-two patients with petroclival meningiomas were treated surgically at the authors’ institution from 1986 to 2015. Patient demographics, overall survival, local tumor control rates, and functional outcomes according to multimodal treatments, as well as chronological change in management strategies, were evaluated. The mean clinical and radiological follow-up periods were 121 months (range 1–368 months) and 105 months (range 1–348 months), respectively.RESULTSA posterior transpetrosal approach was most frequently selected and was followed in 44 patients (48%); a simple retrosigmoid approach, undertaken in 30 patients, was the second most common. The initial extent of resection and following adjuvant treatment modality were classified into 3 subgroups: gross-total resection (GTR) only in 13 patients; non-GTR treatment followed by adjuvant radiosurgery or radiation therapy (non-GTR+RS/RT) in 56 patients; and non-GTR without adjuvant treatment (non-GTR only) in 23 patients. The overall progression-free survival rate was 85.8% at 5 years and 81.2% at 10 years. Progression or recurrence rates according to each subgroup were 7.7%, 12.5%, and 30.4%, respectively.CONCLUSIONSThe authors’ preferred multimodal treatment strategy, that of planned incomplete resection and subsequent adjuvant radiosurgery, is a feasible option for the management of patients with large petroclival meningiomas, considering both local tumor control and postoperative quality of life.