bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crossing Interpretive Boundaries in Sixteenth-Century Istanbul: Aḥmed Sūdī on the Dīvān of Ḥāfiẓ of Shiraz
Authors: Inan Murat Umut 
Published: May 2019

Abstract
This article discusses an Ottoman commentary by Aḥmed Sūdī (d. ca. 1600) on the Dīvān (poetry collection) of Ḥāfiẓ of Shiraz (d. ca. 1390), a Persian literary masterpiece that enjoyed wide readership in the Ottoman world for centuries. In the first part of the article, I introduce Sūdī’s life and works and delineate the structure of his commentary, noting how that structure is underpinned by his philological approach to commentary writing. In the second part, I focus on Sūdī’s interpretation of the opening verse of the Dīvān and compare it with that of his predecessors to highlight and contextualize Sūdī’s commentarial approach. I conclude by illustrating how his grammatical-lexicographical analysis aimed to liberate the celebrated Dīvān from the dominant tradition of allegorical interpretation.
The Font that Never Was: Linotype and the “Phonetic Chinese Alphabet” of 1921
Authors: Mullaney Thomas S. 
Published: May 2019

Abstract
Since the invention and globalization of hot metal printing in the United States and Europe, engineers and entrepreneurs dreamt of a day when linotype and monotype technologies would absorb Chinese script into its growing repertoire of non-Latin writing systems, just as they had Arabic, Armenian, Burmese, Devanagari, Hebrew, Korean, and over one hundred other scripts. In the early 1920s, the much-celebrated release of a new font—the “Chinese Phonetic Alphabet” by Mergenthaler Linotype, and later by the Monotype corporation—led many to believe that the day had finally come. This article charts out the quixotic history of Linotype and Monotype’s efforts to enter the Chinese market, examining the linguistic challenges that had long prevented China’s absorption into a Western-dominated “hot metal empire,” the design process by which artists in Brooklyn and London crafted these new fonts, and ultimately the cultural misunderstandings that doomed the projects to failure.
Arabic Hot Metal
Authors: Nemeth Titus 
Published: May 2019

Abstract
This article investigates the beginnings of Arabic typographic composition with typesetting machinery. It discusses different claims in literature of the first instance of mechanical composition and juxtaposes them with findings from original research in archives of typesetting machinery manufacturers active at the beginning of the twentieth century. Based on this evidence, it suggests a new account of the development and use of the first Arabic casting machine. The article raises geographical and socio-cultural aspects that provided the circumstances for this development and re-situates it from the Middle East to the United States. It identifies the manufacturer of the first Arabic composition machine and type founts, as well as the customer who initiated and contributed to its development. It then considers how the Arabic Linotype was likely conceived in a collaboration between the customer and the manufacturer, pooling cultural and technical expertise for this pioneering effort. Finally, the article discusses the resulting type fount and considers its characteristics from a technical and a typographic-aesthetic perspective, illustrating some of the effects mechanisation had on Arabic typography.
Philological Reversion in Post-Apartheid South Africa: The Sand Writing and Alternate Alphabets of Willem Boshoff
Authors: Campbell Kurt 
Published: May 2019

Abstract
This article focuses on the conceptual implications of specific works of contemporary artist and wordsmith Adriaan Willem Boshoff. Boshoff uses his creations to challenge the terms of the current debate around indigenous languages in southern Africa through artworks such as Blind Alphabet and his Sand Writing Series. These works call viewers to an emphatic return to an understanding of scripts (and the worlds they produce) as embodied systems of tradition that occupy the central place not only in the groups they serve, but indeed in a larger vision of a culturally tolerant and affirmative nation. The article tracks key South African educational policies such as the Apartheid era Bantu Education Act of 1953, and the Corrective Language Act of 1998 after the first democratic elections to contextualize the politics of legislative development in South Africa as related to indigenous scripts and languages. Beyond this bureaucratic history, the article foregrounds partisan agency that individuals such as Wilhelm Bleek, Lucy Lloyd and Magrieta Jantjies displayed as custodians of endangered scripts and languages, culminating in a discussion of the provocative works Boshoff created to stimulate critical thought on contemporaneous philological concerns in South Africa.
Enabling Modernity: Innovation in Original Modulated Greek Typefaces, 1998–2007
Authors: Leonidas Gerry 
Published: May 2019

Abstract
This article discusses the associations with tradition, modernity, innovation, and revivalism contained within, and enabled by, three seminal Greek typefaces for continuous reading in a modulated style, developed from 1998 onwards outside Greece. It starts with an analysis of the historical model of types cut by Firmin Didot; this style was later adopted by the Monotype Corporation for hot-metal composition, and survived across technologies well into the digital era. It provides a reference point for subsequent work, and informed new digital typefaces, starting with Adobe Systems’ Minion Pro (1998). The article discusses Adobe’s programme of developing large typographic families with Greek complements, which explicitly pushed the design envelope with each iteration. It examines the approaches taken for features such as the first pairing of monotonic and polytonic diacritics, the pioneering of functionally correct diacritics over small capitals, and their impact on wider practice. Parallel efforts that reinforced this trend by Microsoft, as well as notable independent work, are referenced in the context of active explorations of the relationship between Latin and Greek styles by non-Greek designers. The article concludes that the period between 1998–2007 has been revolutionary for Greek typefaces for continuous text.
The Incompatibles? Socialism, Academia, Populism
Authors: Brass Tom 
Published: May 2019

AbstractTraced here is the historical role of academia in the way revolution and socialism have vanished from the leftist agenda, together with its political and ideological effects and implications. Thus a similar path was followed from the late 19th century onwards by the reformism/revisionism of katheder-socialists, and from the 1980s onwards by the ‘new’ populist postmodernism in academia. Both privileged culture and reified peasant and ethnic identity, thereby replacing Marxist theory and concepts (class, revolution, socialism, state capture) with other forms of empowerment (parliamentary, resistance-to-the-state) that did not involve a transcendence of the accumulation process. In each instance, reformist/revisionist compromise with capitalism, together with a failure to address both the presence of the industrial reserve army labour and the resulting intensification of labour market competition, has helped to pave the way for the rise of the far right.
Updraft Constraints on Entrainment: Insights from Amazonian Deep Convection
Authors: Anber Usama M. , Giangrande Scott E. , Donner Leo J. , Jensen Michael P. 
Published: May 2019

AbstractMixing of environmental air into clouds, or entrainment, has been identified as a major contributor to erroneous climate predictions made by modern comprehensive climate and numerical weather prediction models. Despite receiving extensive attention, the ad hoc treatment of this convective-scale process in global models remains poor. On the other hand, while limited-area high-resolution nonhydrostatic models can directly resolve entrainment, their sensitivity to model resolution, especially with the lack of benchmark mass flux observations, limits their applicability. Here, the dataset from the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign focusing on radar retrievals of convective updraft vertical velocities is used with the aid of cloud-resolving model simulations of four deep convective events over the Amazon to provide insights into entrainment. Entrainment and detrainment are diagnosed from the model simulations by applying the mass continuity equation over cloud volumes, in which grid cells are identified by some thresholds of updraft vertical velocity and cloud condensates, and accounting for the sources and sinks of the air mass. Entrainment is then defined as the environmental air intruding into convective cores causing cloud volume to shrink, while detrainment is defined as cloudy grid cells departing the convective core and causing cloud volume to expand. It is found that the diagnosed entrainment from the simulated convective events is strongly correlated to the inverse of the updraft vertical velocities in convective cores, which enables a more robust estimation of the mixing time scale. This highlights the need for improved observational capabilities for sampling updraft velocities across diverse geographic and cloud conditions. Evaluation of a number of assumptions used to represent entrainment in parameterization schemes is also presented, as contrasted against the diagnosed one.
The Southern Ocean Sea Surface Temperature Response to Ozone Depletion: A Multimodel Comparison
Authors: Seviour W. J. M. , Codron F. , Doddridge E. W. , Ferreira D. , Gnanadesikan A. , Kelley M. , Kostov Y. , Marshall J. , Polvani L. M. , Thomas J. L. , Waugh D. W. 
Published: May 2019

Abstract
The effect of the Antarctic ozone hole extends downward from the stratosphere, with clear signatures in surface weather patterns including a positive trend in the southern annular mode (SAM). Several recent studies have used coupled climate models to investigate the impact of these changes on Southern Ocean sea surface temperature (SST), notably motivated by the observed cooling from the late 1970s. Here we examine the robustness of these model results through comparison of both previously published and new simulations. We focus on the calculation of climate response functions (CRFs), transient responses to an instantaneous step change in ozone concentrations. The CRF for most models consists of a rapid cooling of SST followed by a slower warming trend. However, intermodel comparison reveals large uncertainties, such that even the sign of the impact of ozone depletion on historical SST, when reconstructed from the CRF, remains unconstrained. Comparison of these CRFs with SST responses to a hypothetical step change in the SAM, inferred through lagged linear regression, shows broadly similar results. Causes of uncertainty are explored by examining relationships between model climatologies and their CRFs. The intermodel spread in CRFs can be reproduced by varying a single subgrid-scale mixing parameter within a single model. Antarctic sea ice CRFs are also calculated: these do not generally exhibit the two-time-scale behavior of SST, suggesting a complex relationship between the two. Finally, by constraining model climatology–response relationships with observational values, we conclude that ozone depletion is unlikely to have been the primary driver of the observed SST cooling trend.
Perspectives on exercise participation among Canadian university students
Authors: Silver Michelle Pannor , Easty Laura Kathleen , Sewell Karen M. , Georges Rosemary , Behman Amy 
Published: May 2019

Objective: University has been identified as an important time to develop exercise habits. The aim of this study was to examine factors that enhanced exercise participation among a diverse set of undergraduate students and their perceived facilitators as well as barriers to exercising regularly. Setting: A large public university in one of the largest and most ethno-culturally diverse regions of Canada. Method: A mixed-methods design was employed to examine factors associated with regular exercise participation among diverse Canadian undergraduate students ( N = 477). Survey data were analysed using logistic regression analyses to predict regular exercise participation. In addition, six focus group sessions explored barriers and facilitators to regular engagement in exercise ( n = 41). Results: Survey findings indicated that being male, having a parent that attended college, and religious affiliation were predictive of exercising regularly. Thematic analysis of qualitative findings highlighted the complex roles that religion, intimidation, peer support and priority-setting played in college students’ exercise participation. Conclusion: Findings can inform ongoing strategies to promote exercise participation in early adulthood, particularly among diverse college students.
Outcome of expandable endoprosthesis: A single centre retrospective review
Authors: Ajit Singh Vivek , Earnest Kunasingh Dinesh , Haseeb Amber , Yasin Nor Faissal 
Published: May 2019

Purpose: Expandable endoprosthesis allows limb salvage in children with an option to leading a better life. However, the revision rate and implant-related complications impose as a limitation in the skeletal immature. This study investigates the functional outcomes and complications related to expandable endoprosthesis in our centre. Materials and Methods: Twenty surviving patients with expandable endoprosthesis from 2006 till 2015 were scored using Musculoskeletal Tumour Society (MSTS) outcomes instrument and reviewed retrospectively for range of motion of respected joints, limb length discrepancy, number of surgeries performed, complications and oncological outcomes. Patients with less than 2 years of follow-up were excluded from this study. Results: Forty-five percentage patients reached skeletal maturity with initial growing endoprosthesis and 25% of patients were revised to adult modular prosthesis. One hundred fifty-seven surgeries were performed over the 9-year period. The average MSTS score was 90.83%. The mortality rate was 10% within 5 years due to advanced disease. Infection and implant failure rate was 15% each. The event-free survival was 50% and overall survival rate was 90%. Conclusion: There is no single best option for reconstruction in skeletally immature. This study demonstrates a favourable functional and survival outcome of paediatric patients with expandable endoprosthesis. The excellent MSTS functional scores reflect that patients were satisfied and adjusted well to activities of daily living following surgery despite the complications.
A Deep Learning–Based Decision Support Tool for Precision Risk Assessment of Breast Cancer
Authors: He Tiancheng , Puppala Mamta , Ezeana Chika F. , Huang Yan-siang , Chou Ping-hsuan , Yu Xiaohui , Chen Shenyi , Wang Lin , Yin Zheng , Danforth Rebecca L. , Ensor Joe , Chang Jenny , Patel Tejal , Wong Stephen T.C. 
Published: May 2019

PURPOSEThe Breast Imaging Reporting and Data System (BI-RADS) lexicon was developed to standardize mammographic reporting to assess cancer risk and facilitate the decision to biopsy. Because of substantial interobserver variability in the application of the BI-RADS lexicon, the decision to biopsy varies greatly and results in overdiagnosis and excessive biopsies. The false-positive rate from mammograms is estimated to be 7% to approximately 10% overall, but within the BI-RADS 4 category, it is greater than 70%. Therefore, we developed the Breast Cancer Risk Calculator (BRISK) to target a well-characterized and specific patient subgroup (BI-RADS 4) rather than a broad heterogeneous group in assessing breast cancer risk.METHODSBRISK provides a novel precise risk assessment model to reduce overdiagnosis and unnecessary biopsies. It was developed by applying natural language processing and deep learning methods on 5,147 patient records archived in the Houston Methodist systemwide data warehouse from 2006 to May 2015, including imaging and pathology reports, mammographic images, and patient demographics. Key characteristics for BI-RADS 4 patients were collected and computed to output an index measure for biopsy recommendation that is clinically relevant and informative and improves upon the traditional BI-RADS 4 scores.RESULTSFor the validation set, we assessed data from 1,247 BI-RADS 4 patients, including mammographic images and medical reports. The BRISK model sensitivity to predict malignancy was 100%, whereas the specificity was 74%. The total accuracy of our implemented model in BRISK was 81%. Overall area under the curve was 0.93.CONCLUSIONBRISK for abnormal mammogram uses integrative artificial intelligence technology and has demonstrated high sensitivity in the prediction of malignancy. Prospective evaluation is under way and can lead to improvement in patient-physician engagement in making informed decisions with regard to biopsy.
Rising and Falling Trends in the Use of Chemotherapy and Targeted Therapy Near the End of Life in Older Patients With Cancer
Authors: Fang Penny , Jagsi Reshma , He Weiguo , Lei Xiudong , Campbell Eric G. , Giordano Sharon H. , Smith Grace L. 
Published: May 2019

PURPOSE End-of-life (EOL) chemotherapy has been described as the most widespread, wasteful, and unnecessary practice in oncology, with benchmarking aimed to reduce physician use of chemotherapy within 14 days of EOL. We evaluated the recent transformation of EOL chemotherapy and targeted therapy practices nationally. METHODS In patients older than 65 years of age who died as a result of breast (n = 19,887), lung (n = 79,613), colorectal (n = 29,844), or prostate (n = 17,910) cancer between 2007 and 2013, we evaluated the guideline-benchmarked measure of chemotherapy use within 14 days of EOL in SEER-Medicare. Comparison outcomes were nonbenchmarked measures of chemotherapy and targeted therapy across time points within 6 months of EOL. Cochran-Armitage test was used to evaluate temporal trends. Multilevel logistic models and intraclass correlation coefficient was used to evaluate variation in EOL chemotherapy use at the physician level. RESULTS From 2007 to 2013, chemotherapy within 14 days of EOL declined from 6.7% to 4.9% of patients ( Ptrend < .001; ∆ = −1.8%). Similar declines occurred for chemotherapy within 1 month ( Ptrend < .001; ∆ = −1.8%) and 2 months ( Ptrend < .001; ∆ = −1.3%) of EOL. In contrast, chemotherapy within 4 to 6 months of EOL rose ( Ptrend ≤ .04; ∆ = 0.7% to 1.7%), and 43.0% of all patients received chemotherapy within 6 months of EOL. Frequency of targeted therapy use across all time points within 6 months of EOL was stable to marginally rising from 2007 to 2013 ( Ptrend = .09 to .82; ∆ = −0.2% to 1.8%); overall, 1.2% received targeted therapy within 14 days and 3.6% within 1 month of EOL. By 2013, 13.2% of patients received any targeted therapy within 6 months of EOL. In a multilevel model, 5.19% (intraclass correlation coefficient) of variation in 14-day EOL chemotherapy was attributed to the physician level. CONCLUSION With national benchmarking, chemotherapy within 14 days of EOL successfully declined to less than 5%, with comprehensive benchmark uptake by physicians. Results may inform current strategies to help to achieve high-value EOL oncology practice.
Influence of arm swing on cost of transport during walking
Authors: de Graaf Myriam L. , Hubert Juul , Houdijk Han , Bruijn Sjoerd M. 
Published: May 2019

Normal arm swing plays a role in decreasing the cost of transport during walking. However, whether excessive arm swing can reduce the cost of transport even further is unknown. Therefore, we tested the effects of normal and exaggerated arm swing on the cost of transport in the current study. Healthy participants (n=12) walked on a treadmill (1.25 m/s) in seven trials with different arm swing amplitudes (in-phase, passive restricted, active restricted, normal, three gradations of extra arm swing), while metabolic energy cost and the vertical angular momentum (VAM) and ground reaction moment (GRM) were measured.In general, VAM and GRM decreased as arm swing amplitude was increased, except for in the largest arm swing amplitude condition. The decreases in VAM and GRM were accompanied by a decrease in cost of transport from in-phase walking (negative amplitude) up to a slightly increased arm swing (non-significant difference compared to normal arm swing). The most excessive arm swings led to an increase in the cost of transport, most likely due to the cost of swinging the arms. In conclusion, increasing arm swing amplitude leads to a reduction in vertical angular moment and ground reaction moments, but it does not lead to a reduction in cost of transport for the most excessive arm swing amplitudes. Normal or slightly increased arm swing amplitude appears to be optimal in terms of cost of transport in young and healthy individuals.
A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development
Authors: Helker Christian S. M. , Mullapudi Sri-Teja , Mueller Laura M. , Preussner Jens , Tunaru Sorin , Skog Oskar , Kwon Hyouk-Bum , Kreuder Florian , Lancman Joseph J. , Bonnavion Remy , Dong P. Duc Si , Looso Mario , Offermanns Stefan , Korsgren Ole , Spagnoli Francesca M. , Stainier Didier Y. R. 
Published: May 2019

ABSTRACT
An early step in pancreas development is marked by the expression of the transcription factor Pdx1 within the pancreatic endoderm, where it is required for the specification of all endocrine cell types. Subsequently, Pdx1 expression becomes restricted to the β-cell lineage, where it plays a central role in β-cell function. This pivotal role of Pdx1 at various stages of pancreas development makes it an attractive target to enhance pancreatic β-cell differentiation and increase β-cell function. In this study, we used a newly generated zebrafish reporter to screen over 8000 small molecules for modulators of pdx1 expression. We found four hit compounds and validated their efficacy at different stages of pancreas development. Notably, valproic acid treatment increased pancreatic endoderm formation, while inhibition of TGFβ signaling led to α-cell to β-cell transdifferentiation. HC toxin, another HDAC inhibitor, enhances β-cell function in primary mouse and human islets. Thus, using a whole organism screening strategy, this study identified new pdx1 expression modulators that can be used to influence different steps in pancreas and β-cell development.