bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Isolation of Chondroprogenitors from Human iPSCs Based on Cell Surface Markers Identified using a CRISPR-Cas9-Generated Reporter
Authors: Dicks Amanda , Wu Chia-Lung , Steward Nancy , Adkar Shaunak S. , Gersbach Charles A. , Guilak Farshid 
Published: June 2019

SUMMARYArticular cartilage shows little or no capacity for intrinsic repair, generating a critical need for regenerative therapies for joint injuries and diseases such as osteoarthritis. Human induced pluripotent stem cells (hiPSCs) offer a promising cell source for cartilage tissue engineering andin vitrohuman disease modeling; however, heterogeneity and off-target differentiation remain a challenge. We used a CRISPR-Cas9-editedCOL2A1-GFPknock-in reporter hiPSC line, coupled with a surface marker screen, to identify a novel chondroprogenitor population expressing CD146, CD166, and PDGFRβ, but not CD45. Under chondrogenic culture conditions, these triple positive chondroprogenitor cells demonstrated decreased heterogeneity as measured by single cell RNA sequencing, as well as more robust and homogenous matrix production with significantly higher chondrogenic gene expression. Overall, this study has identified a unique hiPSC-derived subpopulation of chondroprogenitors that are CD146+/CD166+/PDGFRβ+/CD45-and exhibit high chondrogenic potential, providing a purified cell source for cartilage tissue engineering or disease modeling studies.
From seed to flour: sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
Authors: da Cunha Josiane Araújo , Nabas Roseane Claro , Rolim Priscilla Moura , da Silva Chaves Damasceno Karla Suzanne Florentino , de Sousa Júnior Francisco Canindé , Seabra Larissa Mont’Alverne Jucá 
Published: June 2019

ABSTRACTReduction of waste from food industry and food services is a current concern due to the large amount of waste generated, including peels and fruit seeds. The objective of this study was to obtain a flour produced from Cantaloupe melon seeds (Cucumis melo L. var. reticulatus) and to evaluate the viability of using the product as an ingredient in cake manufacturing. In this study, different formulations were developed: standard cake – 0% (F1) and cakes containing melon seed flour as substitute of wheat flour in 10% (F2), 30% (F3), and 50% (F4) concentrations. Centesimal composition, dietary fibre, structural and morphological characterization, determination of mineral composition, and evaluation of fatty acids profile in melon seed flour were carried out. To determine the overall acceptance of cake formulations, sensory analysis was performed with 135 non-trained panelists, which also included the identification of sensorial attributes using the Just About Right ideal scale test. The results showed that the melon seed flour has considerable nutritional value, with 18% proteins, 3% moisture, 4% ash, 30% lipids, and 35% dietary fibre. Melon flour also has a significantly high content of minerals, mainly phosphorus (1507.62 mg/100 g), potassium (957.35 mg/100 g), and magnesium (504.03 mg/100 g). The polyunsaturated fatty acid fraction was the most abundant in melon seed flour, with predominance of omega-6 fatty acids (17.95 g/mg of sample). Sensorial analysis disclosed good acceptance for formulations containing 10% and 30% of melon seed flour, with the 10% formulation being the most accepted. The research showed the feasibility of using the melon seed flour in cake production, as well as the possibility of using food waste in restaurants and food industries in order to adhere to sustainable production actions.
Potential Autoimmune Association between Benign Paroxysmal Positional Vertigo and Immune-mediated Skin Conditions: Population-based Cohort Study
Authors: Hahn Hyung Jin , Kwak Sang Gyu , Kim Dong-Kyu , Kim Jong-Yeup 
Published: June 2019

ABSTRACTBackgroundBenign paroxysmal positional vertigo (BPPV), an idiopathic disorder of sudden sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that BPPV may be related to or triggered by autoimmune conditions, notably hypothyroidism and giant cell arteritis (GCA).ObjectiveThese evidences prompted the authors to entertain the possibility of immunological bridge between BPPV and the two skin conditions. The authors have tested this hypothesis with population-based cohort from the National Health Insurance Service Database of Korea.MethodsA cohort of 1.1 million patients was extracted from the DB. Using χ2 tests, prevalence of the two skin disorders in terms of BPPV status was analysed.ResultsIn AD patients, the prevalence of BPPV was 30% lower, while there was no statistically significant relationship between BPPV prevalence and vitiligo. The relationship between vitiligo and BPPV was significant in younger subgroup only. Socio-economic subgroup analysis revealed the observed patterns are primarily a middle-upper class phenomenon.LimitationsUncertainty regarding temporal sequence of onset, and lack of detail on disease severity and subtype might have kept the authors from drawing more refined conclusion.ConclusionAD and vitiligo might be linked to BPPV through the action of certain components of cellular immunity, but follow-up studies based on large population cohort would be needed to add more substance to our findings.
Fractal dimension, occupancy and hotspot analyses of B cell spatial distribution predict clinical outcome in breast cancer
Authors: Wortman Juliana C. , He Ting-Fang , Solomon Shawn , Zhang Robert Z. , Rosario Anthony , Wang Roger , Tu Travis Y. , Schmolze Daniel , Yuan Yuan , Yost Susan E. , Li Xuefei , Levine Herbert , Atwal Gurinder , Lee Peter P. , Yu Clare C. 
Published: June 2019

AbstractWhile the density of tumor-infiltrating lymphocytes (TILs) is now well known to correlate with clinical outcome, the clinical significance of spatial distribution of TILs is not well characterized. We have developed novel statistical techniques (including fractal dimension differences, a hotspot analysis, a box counting method that we call ‘occupancy’ and a way to normalize cell density that we call ‘thinning’) to analyze the spatial distribution (at different length scales) of various types of TILs in triple negative breast tumors. Consistent with prior reports, the density of CD20+ B cells within tumors is not correlated with clinical outcome. However, we found that their spatial distribution differs significantly between good clinical outcome (no recurrence within at least 5 years of diagnosis) and poor clinical outcome (recurrence with 3 years of diagnosis). Furthermore, CD20+ B cells are more spatially dispersed in good outcome tumors and are more likely to infiltrate into cancer cell islands. Lastly, we found significant correlation between the spatial distributions of CD20+ B cells and CD8+ (cytotoxic) T cells (as well as CD3+ T cells), regardless of outcome. These results highlight the significance of the spatial distribution of TILs, especially B cells, within tumors.Significance StatementImmune cells can fight cancer. For example, a patient has a good prognosis when a high density of killer T cells, a type of immune cell that can kill cancer cells, infiltrates into a tumor. However, there is no clear association between prognosis and the density of B cells, another type of immune cell, in a tumor. We developed several statistical techniques to go beyond cell density and look at the spatial distribution, i.e., the pattern or arrangement of immune cells, in tumors that have been removed from patients with triple negative breast cancer. We find that B cells and killer T cells tend to be more spread out in the tumors of patients whose cancer did not recur.
Design thinkers’ profiles and design thinking solutions
Authors: Corrales-Estrada Martha 
Published: June 2019

Purpose
The purpose of this paper is to understand how the profiles of design thinkers influence particular design-thinking solutions. It proposes to identify who (profiles), how (design-thinking methodologies) and what (outcomes as an innovation roadmap: process, product, business model, channel, brand, etc.), since the ways professional designers tackle a problem to reach an innovative solution is related to the designers’ profile.

Design/methodology/approach
The paper opted for an exploratory study using a focus group, composed of eight design thinkers and experts. An online survey was also sent to 123 DT leaders, with a return rate of 41 surveys, who worked on an end-to-end innovation project. The data were complemented by documentary analyses.

Findings
The paper provides empirical insights into the importance of selecting a diverse DT team. The team composition must be diverse because different profiles are required for different types of innovation and also for each DT phase to create value.

Research limitations/implications
Given the exploratory research approach being used in the paper, the research results may lack generalization to different contexts. Therefore, researchers are encouraged to test the proposed propositions further, using a larger sample that includes designers from different countries and testing eventual hypotheses.

Practical implications
The paper includes implications to increase the success rate of business innovations, and to reduce the associated costs that continue to increase for trial and error methods.

Originality/value
The paper fulfills an identified need to study how the DT profile and phases, empathize, define, ideate, prototype and test, require the correct skills and leadership throughout the whole process for effective outcome implementation.
Food information presentation: consumer preferences when eating out
Authors: Bray Jeff , Hartwell Heather , Price Sarah , Viglia Giampaolo , Kapuściński Grzegorz , Appleton Katherine , Saulais Laure , Perez-Cueto Federico J.A. , Mavridis Ioannis 
Published: June 2019

Purpose
Advances have been made in the provision of nutritional and ingredient information on packaged food, however, there is a need to translate this to eating out reflecting consumer desire for greater transparency and knowledge of menu content. The purpose of this paper is to assess consumer’s preferences for food information presentation in four European countries (UK, Greece, Denmark and France) in a workplace dining setting.

Design/methodology/approach
This study focusses on workplace canteens since the regularity in which they are used provides an important context and potential for behaviour change. An exploratory phase designed iteratively in collaboration with experts, end-users and researchers (qualitative) informed a survey (quantitative) conducted in four European countries. The survey was used to examine workplace diners’ preferences towards food information presentation.

Findings
Differences were found and clustered (n=5) to “heuristic processors” (33 per cent) “brand orientated” (25 per cent) “systematic processors” (17.3 per cent) “independent processors” (16.1 per cent) and “tech-savvy” (8.6 per cent). Dual-process theories were used to analyse the findings and produce new insight into how menu information can be most effectively delivered.

Originality/value
When eating-out consumers struggle to make choices or make the wrong choice from a health perspective, partly caused by a lack of nutrient profile information as well as other criteria of concern. Giving catering managers the understanding of preferred communication channels can enable a more competitive operator. Traffic light labelling was the optimal presentation with the opportunity for consumers to discover more detailed information if desired. For the first time this research has given operational clarity whilst allowing food providers to be considered as part of corporate health.
The effect of career adaptability on career planning in reaction to automation technology
Authors: Zhang Wenguang , Guan Xiaoyu , Zhou Xueqin , Lu Ji 
Published: June 2019

PurposeThis study investigated employees’ career planning in preparation for the impact of manufacturing transformation triggered by automation technology. Built on career construction theory, the purpose of this paper is to conceptualize career planning as an attempt to integrate oneself into the social environment. In this process of integration, career adaptability is a critical psychological resource for adaptation to anticipated changes.Design/methodology/approachThrough an online survey, 476 participants answered questions regarding the following aspects: perceptions of the threats and opportunities posed by automation technology; career adaptability, that is, career-related concern, control, curiosity, and confidence in adapting to occupational transitions; and career plans and actions to address the challenge, including short-term job crafting behaviors and long-term career adjustment plan.FindingsThe results showed that opportunity and threat perceptions were associated with one’s job crafting behavior and long-term career adjustment plan and such relationships were moderated by career adaptability and work experience relevant to automation technologies. Specifically, career adaptability is a psychological resource helping individuals deal with perceived challenges, while relevant work experience moderated one’s strategies to catch opportunities.Originality/valueThis study contributes to the understanding of psychosocial determinants for better career planning in the midst of the industrial revolution. Policies that aim to prepare workers for the upcoming social transition may benefit from this study to leverage adaptive and proactive behaviors at a societal level.
Design and construction risks in BOT type mega transportation projects
Authors: Aladağ Hande , Işık Zeynep 
Published: June 2019

Purpose
In build-operate-transfer (BOT) transportation projects, design and construction phases are critical in terms of their effect on time and cost overruns. The purpose of this paper is to identify the role of risk factors affecting these phases and their significance level for BOT transportation projects.

Design/methodology/approach
Design and construction risks were determined and then validated by focus group discussions. Afterwards, an illustrated case study was presented to better understand the effects of determined risks in a BOT mega transportation project. As the last step of the study, the fuzzy analytical hierarchy process method was used to prioritize risk factors.

Findings
The prominent risk factors were found out as occupational accidents, integration between design and construction phases and excessive design variations.

Research limitations/implications
Different kinds of BOT transportation projects in different countries might be executed very differently considering specific social, political, economic and other factors. However, the results of the study are important in terms of the specific lessons learned from the case study that can be used as a foundation for developing possible risk mitigation measures.

Originality/value
Though the risk management of BOT projects has been investigated frequently in the literature, there is a knowledge gap in the quantitative evaluation of risk significance specific to design and construction risks. The prioritization of determined risks with an associated case from a mega transportation project will contribute to the BOT project practitioners about possible challenges in design and construction phases in BOT mega transportation projects.
Process conflict and employee well-being
Authors: Kuriakose Vijay , S. Sreejesh , Jose Heerah , M.R. Anusree , Jose Shelly 
Published: June 2019

PurposeThe primary objective of this paper is to extend the Activity Reduces Conflict Associated Strain (ARCAS) model. To test the ARCAS model, the study aims to examine the effect of process conflict on employee well-being and the role of negative affect as an intrapersonal mechanism linking process conflict and employee well-being. Further, to extend the emerging ARCAS model, the study examines whether the assumed indirect effect of process conflict on employee well-being through negative affect is conditional upon levels of conflict management styles.Design/methodology/approachIn total, 554 software engineers working in information technology firms responded to the administered questionnaire and hypothesised relationships were tested using Process Macros.FindingsThe findings indicate that process conflict is negatively related to employee well-being and the negative affect state mediates the relationship between process conflict and employee well-being. As hypothesised, it was found that the indirect effect of process conflict on employee well-being through the negative affect state is conditional upon levels of conflict management styles of the employees.Research limitations/implicationsThe study contributes to the conflict literature by establishing the detrimental effect of process conflict on employee well-being. The study also established the explanatory mechanism linking process conflict and employee well-being. Further, the study extended the emerging ARCAS model by establishing the moderating role of conflict management styles as well as the conditional indirect effect.Practical implicationsThe study highlighted the within-individual effect of process conflict in deteriorating employee well-being. The study provides valuable insights to the managers and practitioners about how individuals’ conflict management styles influence well-being.Originality/valueThe study specifically examined the effect of process conflict, which was omitted from conflict literature considering it the same as task conflict, on employee well-being. The study established the within-individual mechanism through which process conflict diminishes employee well-being. Also, the study extended the ARCAS model by examining the effect of conflict management styles with the aid of Affective Events Theory.
Exploring new frontiers? “Neo-slumming” and gentrification as a tourism resource
Authors: Pieroni Raphaël , Naef Patrick James 
Published: June 2019

Purpose
The purpose of this paper is to analyse urban transformation as a tourism resource. Tourism is undeniably a powerful motor for urban transformation but in return, urban transformation can represent a resource for actors related to tourism. More precisely this paper focuses on one major transformation of modern cities: gentrification.

Design/methodology/approach
The central hypothesis of this paper is that gentrification accompanies tourism, but that gentrification itself may also become an object of the tourist gaze. The paper focuses on local guides and small touristic entrepreneurs in order to identify the tensions that might arise. The presentation of two guided tours – “Subculture Brixton Nightlife Tour” and “Where Brooklyn At?” – will enable us to explore how the gentrification of Brixton (London) and Brooklyn (New York) may be used as a tourism resource for local private entrepreneurs.

Findings
Results presented here are based on ethnographic methods such as observation as well as content analysis and semi-directive interviews. Mobilising the historical concept of “slumming”, this paper proposes an extended conceptual framework, “neo-slumming”, to analyse evolving tourism practices in modern cities, practices that are considered here as tourism’s new frontiers.

Originality/value
However, as tourism transforms cities, the process itself is now of interest to tourists and thus becomes a resource for sector businesses (Naef, 2018). Yet studies about the touristification of urban transformation are still quite rare. This analysis aims to fill this gap by looking at the way a process, such as some spectacular, rapid or radical transformation of the urban fabric, can become a touristic resource associated with specific narratives and representations. In this context, the tourist gaze (Urry, 2002) is directed on a resource characterised by its ongoing change.
The impacts of organizational learning capacities on relationship-specific innovations
Authors: Choi Kyuyeong , Jean Ruey-Jer Bryan , Kim Daekwan 
Published: June 2019

PurposeOrganizational learning is a critical factor in generating firm innovation. While the firms are working with global business partners, not only does their absorptive learning capacity (ALC) with business partners play an important role in generating innovation from the inter-partner firm relationship, but their joint learning capacity (JLC) does as well. However, little research has simultaneously examined absorptive and JLC on innovation in global supply chain relationships. The paper aims to discuss this issue.Design/methodology/approachDrawing on the knowledge-based view, inter-partner learning theory and resource dependence theory, the current study investigates the effects of two organizational learning capacities on relationship-specific innovation: ALC (firm-level) and JLC (relationship level). In addition, a firm’s focus on exploitation/exploration strategy and supplier dependence is further incorporated into the study as moderators. Moreover, solutions to endogeneity issues are discussed and reported due to the usage of survey data. The model of this study was tested using data collected from 190 electronics firms in Taiwan as an emerging market.FindingsThe findings of this research reveal that JLC in the presence of absorptive capacity positively influences relationship-specific innovation. Furthermore, the exploitation focus of a firm positively moderates the effects of both absorptive and JLC on relationship-specific innovation. However, supplier dependence negatively moderates the effect of JLC.Research limitations/implicationsThe research provides some theoretical implications for learning and innovation generation in global supply chains.Practical implicationsThe paper provides some managerial implications for how to manage innovations in the global supply chain relationships.Originality/valueThis paper fulfills an identified need to study how innovation generation can be better managed in global supply chain contexts.
Data hiding the truth for the last few years: a panel data analysis of crimes against women
Authors: Ragunathan Aarthee , Devarasan Ezhilmaran 
Published: June 2019

PurposeThe offence against femininity has not only destroyed India’s development but also its future. When it comes down to the most important factor like sex, the social evils like “sati” and “dowry” that had been plaguing our country have been banned in India. India is the most dangerous nation in regard to sexual violence against women, according to the summary of the Thomson Reuters Foundation, 2018. The purpose of this paper is to determine the relationship between the total populations of women with other different types of women crime in all states in India.Design/methodology/approachThis paper will review existing panel data analysis literature and apply this knowledge in finding the highly occurred women crimes in India. Using R software the following models are analysed: pooled ordinary least squares, fixed effects models and random effects models for analysing the women crimes in India.FindingsIn this paper, the authors identify that the fixed effects model is more appropriate for the analysis of women crimes in India.Practical implicationsViolence against women is a social, economic, developmental, legal, educational, human rights and health issue. This paper can be used to find the importance of women crime types. Moreover, the police or legal department can take actions according to the crime types.Originality/valueThere is a lack of literature considering the crimes against women. This will help the society to understand women crime types because the only type of violence that has received much attention by the media is rape. But, through our panel data analysis, we conclude that kidnapping, abduction and dowry death are the most occurred crimes against women in India.