bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female Sex as a Risk Factor for Ischemic Stroke and Systemic Embolism in Chinese Patients With Atrial Fibrillation: A Report From the China‐AF Study
Authors: Lan Di‐Hui , Jiang Chao , Du Xin , He Liu , Guo Xue‐Yuan , Zuo Song , Xia Shi‐Jun , Chang San‐Shuai , Wen Song‐Nan , Wu Jia‐Hui , Ruan Yan‐Fei , Long De‐Yong , Tang Ri‐Bo , Yu Rong‐Hui , Sang Cai‐Hua , Bai Rong , Liu Nian , Jiang Chen‐Xi , Li Song‐Nan , Dong Jian‐Zeng , Lip Gregory Y. H. , Chen Ai‐Hua , Ma Chang‐Sheng 
Published: September 2018

Background

Previous studies have provided conflicting results as to whether women are at higher risk than men for thromboembolism in the setting of atrial fibrillation (
AF
). We investigated whether women with
AF
were at higher risk of ischemic stroke in the China‐AF (China Atrial Fibrillation Registry) Study.

Methods and Results

A total of 19 515 patients were prospectively enrolled between August 2011 and December 2016 in the China‐
AF
Study. After exclusion of patients receiving anticoagulation or ablation therapy, 6239 patients (2574 women) with results from at least 6 months of follow‐up were used for the analysis. Cox proportional hazards models were performed to evaluate whether female sex was an independent risk factor for thromboembolism after multivariate adjustment. The primary outcome was the time to the first occurrence of ischemic stroke or systemic embolism. After a mean follow‐up of 2.81±1.46 years, 152 female patients reached the primary outcome, as compared with 172 male patients. Crude incidence rates of thromboembolism between women and men were of borderline statistical significance (2.08 versus 1.68 per 100 patient‐years,
P
=0.058). After multivariable analysis, female sex was not independently associated with an increased thromboembolism risk (hazard ratio 1.09, 95% confidence interval 0.86‐1.39). There was no significant difference in thromboembolism risk by sex stratified by age and presence or absence of risk factors (
P
for interaction all >0.1).

Conclusions

Although crude incidence rates of thromboembolism were higher in Chinese female patients with
AF
compared with male patients, female sex did not emerge as an independent risk factor for thromboembolism on multivariate analysis.

Clinical Trial Registration

URL
:
http://www.chictr.org.cn/
. Unique identifier: Chi
CTR
‐
OCH
‐13003729.
Die Königsbeurteilungen und die Literargeschichte des Deuteronomistischen Geschichtswerks Anmerkungen zu einer kontroversen Diskussion
Authors: Lee Sang-Won 
Published: September 2018

Abstract
In der gegenwärtigen Forschungsdiskussion um die Literargeschichte des bzw. Existenz eines Deuteronomistischen Geschichtswerks spielen redaktionsgeschichtliche Differenzierungen zwischen den Beurteilungskriterien Kulteinheit und Kultreinheit sowie den Beurteilten Königen und Volk eine große Rolle. Eine Untersuchung der Königsbeurteilungen in 1-2 Könige zeigt jedoch, dass sowohl die Kriterien Kulteinheit und Kultreinheit als auch die Zuweisung der Verantwortlichkeit an Könige und Volk in komplexer aber systematischer Weise aufeinander bezogen sind. Eine literargeschichtliche Differenzierung entlang dieser Linien erweist sich als schwierig. Zudem lässt der Umgang mit den Kriterien Kulteinheit und Kultreinheit in der Darstellung der vorstaatlichen Epochen narrative Strategien erkennen, die darauf zielen, zwischen Idealkonzept und dargestelltem Geschichtsverlauf zu vermitteln. Die These M. Noths zu einem dtr Werkzusammenhang in Dtn-2Kön ist daher (mit kleinerem Modifikationen) keineswegs obsolet.
Invasive mosquitofish (Gambusia holbrooki) affect egg-laying and behaviour of Spanish pygmy newts (Triturus pygmaeus)
Authors: Cabrera-Guzmán Elisa , Díaz-Paniagua Carmen , Gomez-Mestre Ivan 
Published: September 2018

Abstract
Invasive species are one of the main causes of amphibian declines worldwide, often through direct predation. Even species or life stages that may not be prone to predation by invasive animals can be affected through alterations of their reproductive behaviour and/or performance. This aspect is less commonly investigated, and may be important for understanding the full impact of invasive species on local amphibian populations. We used laboratory experiments to measure effects of the invasive Eastern mosquitofish (Gambusia holbrooki) on gravid pygmy newts (Triturus pygmaeus) from southern Spain. Gravid newts altered their position in the water column by moving from the bottom of the aquaria to the surface when in the presence of free-swimming mosquitofish, presumably to reduce physical contact with them. Newts also detected and consumed less prey in presence of free mosquitofish. Newts exposed to caged or free-swimming mosquitofish laid fewer eggs than newts not exposed to the invasive species, suggesting that chemical or visual cues alone were sufficient to alter the behaviour of gravid newts. Our results suggest that mosquitofish can reduce the reproductive success of native pygmy newts in the wild, highlighting the need for management efforts to mitigate this impact.
Beckett et Berio à l’ écoute de voix innommables
Authors: Negrete Fernanda 
Published: September 2018

Résumé
Cet article propose un dialogue intermédial entre L’ innommable de Beckett et la Sinfonia de Luciano Berio, où l’ on entend des fragments de The Unnamable, afin d’ entreprendre une analyse des questions de la voix, de la subjectivité, et de leur irréductible expérience hétérogène face à la parole et au langage. Sinfonia incite à une entente non-narrative du texte beckettien en français, là où la folle multiplication de sens nous heurte, à travers les énoncés musicaux beckettiens, au non-dit et à l’ indicible. Le Purgatoire de Dante fournit la “scène primitive” qui suscite telle disruption essentielle du sens et d’ une lecture linéaire chez Beckett. L’ article conclut par une réflexion autour de la fonction résonnante de l’ eau dans Sinfonia et dans L’ Innommable.
“Torn by Enormous Pauses”
Authors: Hensch Laura 
Published: September 2018

Abstract
Like Beckett’s description of Beethoven’s seventh symphony as a “sound surface, torn by enormous pauses,” the language surface in How It Is is broken by typographic spaces. Drawing on the imagery in the German Letter in conjunction with two similar aesthetic metaphors—Hölderlin’s theory of tragic caesurae as “counter-rhythmic rupture[s]” and Deleuze’s understanding of Beckett’s “pure images” as “holes” in language—I identify two types of caesurae in How It Is. Finally, after establishing the way in which Hölderlin’s caesura and Deleuze’s “pure image” overlap, I locate the work’s most fundamental rupture and propose that, in a reading based purely on form, this rupture has a pivotal function comparable to the turning point of a conventional novel.
Ghosts of Love
Authors: Gontarski Stanley E. 
Published: September 2018

Abstract
This essay focuses on two laboratory performances. First was my staging of Ohio Impromptu, a bi-lingual, imagistic, multi-media performance that I directed in Sopot, Poland in May of 2016 with Polish filmmaker Elvin Flamingo as a laboratory performance. Part of the attraction to such a research exercise was the opportunity to work again with English actor Jon McKenna, and with legendary Polish actor Ryszard Ronchewski, who played Lucky in a Polish production of Waiting for Godot in the 1950s. The following year I returned to what I saw as an incomplete research project, as I was afforded a similar opportunity to explore another work for a laboratory performance, “… but the clouds …,” a treatment of love lost, through abandonment or death, perhaps, as a set of haunting images or images of hauntings. These were attempts to excavate possibilities of the work in intense, two-day laboratory rehearsals and performances. In the case of “… but the clouds …,” I worked with Polish filmmakers Szymon and Martyna Eliasz and their team, with whom we decided to film and record all of the teleplay except the comings and goings, and the patterns of repetitive movement.
L’ écho de la correspondance
Authors: Podvin Virginie 
Published: September 2018

Résumé
Samuel Beckett, dans sa recherche d’ un ailleurs littéraire, engage la création sur les voies poétique et picturale. Mais pas seulement. La lecture du premier volume de la correspondance révèle effectivement l’ importance du modèle musical sur les coulisses de la création. En lutte permanente avec le medium mot, Beckett, après avoir, selon son expression, “démontr[é] verbalement son mépris” à l’ égard de ce dernier, convoque le quatrième art.
A multispecialty study of determining the possibility of pregnancy and the documentation of pregnancy status in surgical patients: a cause for concern?
Authors: Ibrahim Ibrahim , Ibrahim Bilal , Yong Guo Liang , Coats Maria , Vujovic Zorica , Wilson Michael SJ 
Published: September 2018

Background Determining the possibility of pregnancy and the documentation of pregnancy status are important considerations in the assessment of females of reproductive age when admitted to hospital. Objectives Our aim was to determine the adequacy of the documentation of pregnancy status and possibility of pregnancy across multiple surgical specialties. Materials and methods A prospective audit of surgical specialties (general, orthopaedics, urology, vascular, maxillofacial, ENT, gynaecology and neurosurgery) within NHS Tayside, in May 2015. Results A total of 129 females of reproductive age were admitted; 69 (53.5%) elective and 60 (46.5%) emergencies. Eighty-four patients (65%) were asked ‘Is there any possibility of pregnancy?’ Pregnancy status was documented in 74% of patients. Eleven (8.5%) patients were not asked about possibility of pregnancy and did not have a documented pregnancy status. Documentation of the use of contraception, sexual activity and date of last menstrual period was noted in 53 (41.1%), 31 (24.0%) and 66 (51.2%) patients, respectively. Conclusions There is a wide variation in the documentation of pregnancy status and possibility of pregnancy amongst surgical specialties. This was not an issue in gynaecology but is an issue in ENT, maxillofacial, neurosurgery, vascular and general surgery. The reasons are unclear. Documentation of pregnancy status using ßhCG assays should be the gold standard, and national guidelines are required.
Fewer women aged 35 and older choose serum screening for Down’s syndrome: Impact and implications
Authors: Lambert-Messerlian Geralyn , Palomaki Glenn E 
Published: September 2018

Objective To quantify changes in the proportion of women aged 35 and older choosing serum screening for Down’s syndrome over time and the effect on false positive and detection rates. Methods From Rhode Island hospital-based laboratory prenatal screening records (2013–2017) we extracted the test performed (Integrated, Combined, Quadruple), maternal age, and Down’s syndrome risk; documented observed changes in maternal age distributions and false positive rates, and modelled the impact of varying proportions of older women choosing screening on each test’s performance using the 2015 United States birth cohort as baseline. Results Over five years, observed false positive rates for Integrated testing declined from 1.9 to 1.3% (−32%). The proportion of older women tested declined from 14.9 to 8.5%, from which modelling predicts a 16% decline in the false positive rate. This is lower than our observed change but consistent with a reduction driven by declining participation by older women. Modelling predicted a detection rate reduction from 89 to 87%. Larger detection rate impacts were predicted for Combined and Quadruple testing. Conclusions This study documents, for the first time, the declining proportion of older women choosing Down’s syndrome serum screening and subsequent impact on screening performance. The American College of Obstetrics and Gynecology recommends offering cell-free DNA screening for these ‘high risk’ pregnancies and uptake may increase further. Screening programmes could consider increasing use of Integrated testing over other serum screening tests or lowering risk cut-offs so false positive rates approach those of 2012 to regain lost detection.
Comparison of intraocular pressure fluctuation before and after cataract surgeries in normal-tension glaucoma patients
Authors: Tojo Naoki , Otsuka Mitsuya , Hayashi Atsushi 
Published: September 2018

Purpose: Cataract surgeries have been shown to reduce intraocular pressure. We used a Sensimed Triggerfish® contact lens sensor to compare intraocular pressure levels and their fluctuation between before and after cataract surgeries in patients with normal-tension glaucoma. Methods: This was a prospective open-label study. Thirteen patients with normal-tension glaucoma were included. All patients underwent a 1-month washout and discontinued glaucoma medications during this study. In each eye, intraocular pressure fluctuations over 24 h were measured with the contact lens sensor before and at 3 months after the cataract surgery. We compared intraocular pressure levels and their fluctuation between before and after cataract surgeries. We used two approaches to evaluate the amplitude of intraocular pressure fluctuations: dual-harmonic regression analysis, and measurement of the difference between the maximum and the minimum value. Results: The mean pre-operative intraocular pressure was 14.7 ± 2.2 mm Hg and mean post-operative intraocular pressure was 11.4 ± 2.2 mm Hg. Cataract surgery significantly decreased intraocular pressure (p = 0.0005). In both methods, the post-operative fluctuations in intraocular pressure over 24 h were significantly smaller than their pre-operative counterparts (dual-harmonic regression analysis: p = 0.0171; difference between the maximum and the minimum: p = 0.0398). Conclusion: Cataract surgery decreased both intraocular pressure values and intraocular pressure fluctuations in normal-tension glaucoma patients.
Automated blood pressure self-measurement station compared to office blood pressure measurement for first trimester screening of pre-eclampsia
Authors: Holm Louise , Stucke-Brander Tone , Wagner Stefan , Sandager Puk , Schlütter Jacob , Lindahl Camilla , Uldbjerg Niels 
Published: September 2018

Background: Preeclampsia is a serious medical disorder affecting pregnancy. Screening in early pregnancy can identify women at risk and enable effective prophylactic treatment. Accurate blood pressure (BP) measurement is an important element of the screening algorithm. Automated self-screening, while attending the first trimester ultra sound scan, using a BP self-measurement (BPSM) station, could be a low-cost alternative to office BP measurements (OBPM) on both arms performed by clinical staff, if the measurement quality can be ensured. Objectives: The aim of this study was to compare automated BPSM using a self-measurement station on one arm, with OBPM performed by clinical staff on both arms. Primary outcome was the difference in mean arterial pressure (MAP) between the two methods and secondary outcomes were safety and practicality issues. Methods: Pregnant women attending ultrasound-examination at 12 weeks gestational age were recruited and randomized to start with having two OBPMs taken on both arms by staff, using two standard validated automatic upper arm BP devices, or self-measuring using an automated BPSM station following a crossover study design. The BPSM station consists of a validated blood pressure device, and an add-on sensor system capable of registering blood pressure values, rest-time, back-supported, legs-crossed, and ambient noise-levels respectively, and providing interactive guidance during the measurement process, for supporting the self-measurement process. Results: A total of 80 complete BP measurement sets were obtained, for a total of 240 BPSM measurements and 320 OBPM measurements. We found no significant difference between the OBPM and BPSM methods (p=0.86) for mean arterial pressure (MAP). However, erroneous measurements were observed frequently during the experiment, mainly during the first of the 3 BPSM measurements (6%), secondary during the second BPSM measurement (3%). Only one data set (1%) was excluded due to OBPM errors. Conclusion: No significant difference in MAP between the two methods was found. Means for detecting and repeating erroneous BP measurements should be implemented. Measurement errors was found in 9 % of the measurement sets which is not acceptable for clinical use. Thus, several measures have been identified in order to properly identify and recover from such measurement errors in the future.
Glycemic Control Maintained over Time and Joint Stiffness in Young Type 1 Patients: What Is the Mathematical Relationship?
Authors: Francia Piergiorgio , Sorelli Michele , Piccini Barbara , Iannone Giulia , Capirchio Laura , Toni Sonia , Gulisano Massimo , Bocchi Leonardo 
Published: September 2018

Background:It is widely known that diabetes can induce stiffness and adversely affect joint mobility even in young patients with type 1 diabetes mellitus (T1D). The aim of this study was to identify a mathematical model of diabetes mellitus long-term effects on young T1D patients.Methods:Ankle joint mobility (AJM) was evaluated using an inclinometer in 48 patients and 146 healthy, sex- BMI-, and age-matched controls. Assuming time invariance and linear superposition of the effects of hyperglycemia, the influence of T1D on AJM was formalized as an impulse response putting into relationship past supernormal HbA1c concentrations with the ankle total range of motion. The proposed model was identified by means of a nonlinear evolutionary optimization algorithm.Results:AJM was significantly reduced in young T1D patients ( P < .001). AJM in both plantar and dorsiflexion was significantly lower in subjects with diabetes than in controls ( P < .001). The identified impulse response indicates that impaired metabolic control requires 3 months to bring out its maximum effect on the reduction of AJM, while the following long-lasting decay phase with the expected AJM recovery times, normally depends on the slow turnover of collagen. HbA1c concentration levels above 7.2% are sufficient to produce a reduction of ankle ROM.Conclusions:In young patients with T1D the lack of glycemic control over time affects AJM. HbA1c levels can serve as a relevant prognostic factor for assessing the progression of LJM in subjects with diabetes.
Association of obesity with colonic findings in screening colonoscopy in a large population‐based study
Authors: Kobiela Jarek , Wieszczy Paulina , Reguła Jarosław , Kamiński Michał F 
Published: September 2018

Background and aimsObesity is associated with an increased incidence of and mortality from colorectal cancer (CRC). Screening colonoscopy seems particularly important for individuals with obesity. The aim of this study is to analyse the characteristics of screening colonoscopy in individuals with obesity.MethodsWe performed a cross‐sectional analysis of records of 75,278 patients from a national colonoscopy screening programme in Poland. The database contained demographic data, colonoscopy results, self‐reported data on weight and height, a standardized screenees’ experience questionnaire and colorectal findings.ResultsAdenoma detection rate and advanced neoplasia detection rate increased significantly in groups of increasing body mass index (BMI). In subjects with morbid obesity, odds ratios for proximal adenoma and proximal advanced neoplasia were 1.69 (95% confidence interval (CI) 1.28–2.21) and 1.66 (95% CI 1.01–2.72), respectively, despite the fact that with BMI increasing over 30 the preparation for colonoscopy was worse. Moreover, caecal intubation increased with increasing BMI. Tolerance of colonoscopy was better and preparation for colonoscopy was less inconvenient in individuals with obesity.ConclusionsObesity and morbid obesity are associated with increased detection of colorectal precursor lesions and better performance of screening colonoscopy. Participation in screening colonoscopy should be emphasized among individuals with obesity, taking into account the burden of CRC in this population.
Fusion Rates of Lateral Lumbar Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein-2
Authors: Nourian Ardalan A. , Harrington Justin , Pulido Pamela A. , McCauley Julie C. , Bruffey James D. , Eastlack Robert K. 
Published: September 2018

Study Design: Retrospective observational case series. Objectives: Lateral lumbar interbody fusion (LLIF) has been widely performed with recombinant human bone morphogenetic protein-2 (rhBMP-2), but the fusion rates using this graft alternative have not been well studied. We aimed to evaluate fusion rates in 1- and 2-level LLIF with rhBMP-2 and their relationship with fixation, as well as rates of BMP-related complications. Methods: Institutional review board (IRB)–approved spine registry cohort of 93 patients who underwent LLIF with rhBMP-2 (71 one-level cases and 22 two-level cases). Minimum 1-year clinical follow-up and computed tomography (CT) scan for fusion assessment. Postoperative CT scans were used to evaluate the rate of fusion in all patients. Instrumentation and complications were collected from chart and imaging review. Results: Average age was 65 years (67% female). For 1-level cases, 92% (65/71) had complete fusion and 8% (6/71) had either incomplete or indeterminate fusion. Three of the 6 patients who had incomplete or indeterminate fusion had bilateral pedicle screw instrumentation, 1 patient had unilateral posterior fixation, and 2 had no fixation. In 2-level cases, 86% (19/22) had complete fusion and 14% (3/22) had either incomplete or indeterminate fusion. The 3 patients who had incomplete or indeterminate fusion did not have fixation. Conclusion: Interbody fusion rates with rhBMP-2 via LLIF was 92% in 1-level cases and 86% in 2-level cases, indicating that rhBMP-2 may be used as a viable graft alternative to allograft options for LLIF. Higher rates of pseudarthrosis occurred when not using fixation.