bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoparticles-mediated Brain Imaging and Disease Prognosis by Conventional as well as Modern Modal Imaging Techniques: a Comparison
Authors: Pan Cheng-Tang , Chang Wei-Hsi , Kumar Ajay , Singh Satya P. , Kaushik Aman Chandra , Sharma Jyotsna , Long Zheng-Jing , Wen Zhi-Hong , Mishra Sunil Kumar , Yen Chung-Kun , Chaudhary Ravi Kumar , Shiue Yow-Ling 
Published: October 2019

Background:Multimodal imaging plays an important role in the diagnosis of brain disorders. Neurological disorders need to be diagnosed at an early stage for their effective treatment as later, it is very difficult to treat them. If possible, diagnosing at an early stage can be much helpful in curing the disease with less harm to the body. There is a need for advanced and multimodal imaging techniques for the same. This paper provides an overview of conventional as well as modern imaging techniques for brain diseases, specifically for tumor imaging. In this paper, different imaging modalities are discussed for tumor detection in the brain along with their advantages and disadvantages. Conjugation of two and more than two modalities provides more accurate information rather than a single modality. They can monitor and differentiate the cellular processes of normal and diseased condition with more clarity. The advent of molecular imaging, including reporter gene imaging, has opened the door of more advanced noninvasive detection of brain tumors. Due to specific optical properties, semiconducting polymer-based nanoparticles also play a pivotal role in imaging tumors.Objective:The objective of this paper is to review nanoparticles-mediated brain imaging and disease prognosis by conventional as well as modern modal imaging techniques.Conclusion:We reviewed in detail various medical imaging techniques. This paper covers recent developments in detail and elaborates a possible research aspect for the readers in the field.
A Cationic Nanomicellar Complex of the Quaternary Amphiphilic Amine RC16+ with Fenretinide as a New Multitasking System for Antitumor Therapy
Authors: Orienti Isabella , Cripe Timothy P. , Currier Mark A. , Cavallari Cristina , Teti Gabriella , Falconi Mirella 
Published: October 2019

:
This study investigated the antitumor effect of a new nanomicellar complex obtained
by combining the antitumor agent fenretinide with a quaternary amphiphilic amine RC16+ also
endowed with antitumor activity.

Methods:
The complex (Fen-RC16+) strongly improved the aqueous solubility of fenretinide (from
1,71 ± 0.08 µg/ml, pure fenretinide to 1500 ± 164 µg /ml, Fen-RC16+ complex) and provided a cytotoxic
effect on SH-SY5Y neuroblastoma cell lines resulting from the intrinsic activity of both the complex
components. Moreover, the mean size of the nanomicellar complex (ranging from 20 ± 1.97 nm to
40 ± 3.05 nm) was suitable for accumulation to the tumor site by the enhanced permeability and retention
effect and the positive charge provided by the quaternary RC16+ induced adsorption of the complex
on the tumor cell surface improving the intracellular concentration of fenretinide.

Results:
All these characteristics made the Fen-RC16+ complex a multitasking system for antitumor
therapy.

Conclusion:
Indeed its in vivo activity, evaluated on SH-SY5Y xenografts, was strong, and the tumor
growth did not resume after the treatment withdrawal.
Molecular Modeling and Docking of Aquaporin Inhibitors to Reveal New Insights into Schistosomiasis Treatment
Authors: Alazmi Meshari 
Published: October 2019

Background:
Schistosomiasis (snail fever/bilharzia), a disease caused by parasitic flatworms
(schistosomes), infects millions of people worldwide. Aquaporins from these organisms
were found to be a potent drug target.

Introduction:
We investigate the possible mechanism of inhibition of Aquaporin (AQP) from
S.mansoni by 5 drug molecules (Praziquantel, Metrifonate, Artimisinin, Albendazole, and Amoscanate).

Methods:
3D molecular structure of Aquaporin was obtained through homology modeling and further
protein-ligand docking and MD simulation were performed.

Results:
VAL-75, ASN-91, ALA-220, ASN-222, ARG-225 amino acids were found to play crucial
role in ligand binding. TRP-71 and other important residues play major role in hydrophobic
interactions stabilizing protein-ligand complexes.

Conclusion:
We hope that this study (with the newly identified aquaporin target) will support the
development of structure and pharmacophore-based novel S. mansoni drugs to control and curb
Schistosomiasis.
Screening of Metal and Antibiotic Resistance in Beta-lactamase Producing Coliform Bacteria from Hospital Wastewater of Northern India
Authors: Alam Manzar , Imran Mohd , Ahmad Syed Sayeed 
Published: October 2019

Aim:
Our exploration work has uncovered the different anti-toxin/metal tolerance and
patterns against the heavy metal resistant coliform microscopic organisms from the aquatic waste
of the hospital. It might give new routes for the treatment of irresistible ailments particularly by
coliform and critical for hazard evaluation as well as hazard management associated with the
effluents of the hospital.

Background:
The higher use of pharmaceuticals, Radionuclides, and other antimicrobial solvents
are the major source of metals in hospital wastewater. The hospital aquatic environment has a high
content of both organic and inorganic matter with living organisms. Bacteria can resist an
antimicrobial agent by producing extracellular enzymes that eliminate antibiotics and metal
toxicity. In this study, we covered the existing patent literature in this area. New patents in the
areas of topically applied antibiotics and agents that can potentiate the achievement of existing
antibiotics may extend their helpful lifetime.

Methods:
Samples were collected from three different Departments of King George Medical
University, Lucknow during the month of December to May (2015-16). Isolation and metal
tolerance of coliform isolates were done on metal amended plates. The antibiotic sensitivity test
was done by disc diffusion method. The plasmid DNA of bacterial isolates was done by the
alkaline lysis method. The conjugation study was also performed in wastewater as well as a
nutrient medium.

Results:
Maximum isolates demonstrated their MICs at 400, 800 and 1600 μg/ml against all the
metals, respectively. The high level of resistance was observed against Methicillin (88.32%,
80.60%) followed by penicillin (75%, 76%), Cephradin (59.52%, 28.84%) and least to
Gentamycine (1.92%, 5.76) in E. coli and Enterobacter, respectively. Of 70%, 78% E. coli and
Enterobacter isolates produce beta-lactamase activity. Six amino acid residues namely, Glu104,
Tyr105, Asn132, Asn170, Ala237, and Gly238 of the beta-lactamase were found in the common
interaction with the selected drugs. Plasmid DNA size ranged between 48-58.8 kb. The
conjugation experiments showed a higher transfer frequency (5.5×10-1 and 3.6×10-1) rate among
antibiotics and metals tested.

Conclusion:
The finding of this study presents a potential health problem as the predominant
coliform species have increasingly been associated with outbreaks of hospital infections. It is
recommended that hospital waste must be properly treated before its release into the environment.
MICE- MASA DEPAN BISNIS PARIWISATA INDONESIA
Authors: Kusuma Chusnu Syarifa Diah 
Published: October 2019

Abstrak: MICE - Masa Depan Bisnis Pariwisata Indonesia. MICE (Meeting, Incentive, Conference, Exhibition) adalah terobosan baru untuk kemajuan pariwisata Indonesia karena dinilai memilki keuntungan 7 kali lipat lebih besar dari leisure tourism. Dampak utama adanya bisnis MICE di Indonesia adalah semakin meningkatnya kesejahteraan masyarakat dan citra pariwisata di daerah destinasi MICE. Potensi MICE Indonesia terlihat dari banyaknya event besar bertaraf internasional yang sering menunjuk Indonesia sebagai tuan rumah, selain itu Indonesia memiliki sumber daya manusia MICE yang profesional, infrastruktur yang berkualitas, sarana dan prasarana akomodasi MICE yang cukup memadai.Kata kunci : MICE, Pariwisata Abstract: MICE - The Future of Indonesia's Tourism Business. MICE (Meeting, Incentive, Conference, Exhibition) is a new innovation in tourism field for the advancement of Indonesian tourism because it has profit 7 times bigger than leisure tourism. The potential of Indonesian MICE can be seen from the many large international events that often designate Indonesia as the host, besides that Indonesia has professional MICE Human Resources, infrastructure, and international accommodation.Keywords : MICE, Tourism
Geochemical Fraction, Mobility And Bioavailability Of Lead In Unsaturated Soil Of Yogyakarta City, Indonesia
Authors: Zaw Aye Saw Aung , Hendrayana Heru , Eka Putra Doni Prakasa , Sato Tsutomo 
Published: October 2019

Lead (Pb) is one of common heavy metals found inthe soil of urban environment. In Yogyakarta City,Indonesia, lead content in the soil was already reported by some researchers, however all of the report were only reveals the distribution of lead concentration in the soil. Therefore, this research paper aims to understand the geochemical fraction leadin the soil of Yogyakarta City and assess the mobility and bioavailability of lead release to the environment. The soil sampling location is selected on Kotagede District, representing the oldest urban area of Yogyakarta city. A shallow bore hole was drill until about 7 m below the surface and soil/sediments weresampled for each 1 m depth started from the surface. Six steps of sequential extraction procedures were carried out to assess the geochemical fraction of Pb for each of soil samples. The sequential extraction shows that the highest amount of Pb in thesoil of Yogyakarta City is found in amorphous ironoxide, crystalline iron oxide and non residual fraction form of Pb. Based on the results of geochemical fraction, the mobility factor of lead can be calculated and reveals low mobility factor range from 0.4 to 3.3%. The mobility of lead is decreased from the surface to the deeper soil, on the other hand the bioavailability of Pb calculated from exchangeable and carbonate fraction is also show low risk of bioavailability. Therefore, it can be concluded that although Pb concentration is high in non-residual fraction, Pb isin low risk condition due to its poor mobility and bioavailability. But, concern on lead contamination should be considered because if the concentration of Pb is enriched over the adsorption capacity of ironoxide, it can easily release to the environment and can impact to human in the future.Keywords: Yogyakarta city, Lead, Sequential extraction, Geochemical fraction
Road to earthquake mitigation: Lesson learnt from the Yogyakarta earthquake 2006
Authors: Pramumijoyo Subagyo 
Published: October 2019

At early in the morning of May 27, 2006, people of Yogyakarta was stroke by earthquake and mostly heavily damaged building are in lowland or Yogyakarta depression where is occupied by the Young Merapi sediments. The magnitude of earthquake is Mw = 6.2 and USGS rapid moment tensor shows that this earthquake was due to strike-slip fault movement.Seismic history of Yogyakarta area shows that Yogyakarta was stroke by several earthquakes with different epicenter location. At least two earthquakes stroke the area, that is in 1876 and 1943. The damages are similar to the damages of actual earthquake. Yogyakarta depression is mostly covered by Young Merapi sediments that consist of tuff, volcanic ash, breccias, agglomerate and lava with Quaternary in age. The thickness of this sediment is up to 100 m.Our reactive work was to establish firstly zone of damage. For this purpose, we made aerial photograph along the most damaged area. In the same time one of our teams go to the field to measure the cracks, and the other teams to observe liquefaction, hydro geologic measurement, and observation on landslide induce by earthquake. Secondly, we must understand the soil properties and its thickness, because in seismic history it was a similar damage on the same area due to earthquakes however the earthquake epicenters were different. For this purpose we utilize the method of micro-tremors. We also made some drilling until 60 m each, measuring seismic velocity on bore hole, and magneto telluric measurement. We also have helped by Kyushu University in installing micro seismic net work. The research was followed by either undergraduate and graduate students. Fortunately our research was financed by AUN/Seed Net – JICA. Some of the results were published in a book entitled The Yogyakarta Earthquake of May 27, 2006. Another outcome is the Maps of Microzonation and Earthquake Hazard of Bantul Area that dedicated to Bantul people.Based on aerial photograph observation and field observation on Bantul Regency, especially along the Opak River, and to Wonosari to the East, there was no surface ruptures, so there is no fault on surface. Interpretation of aftershock data was showing the difference cluster. There is still open problem in determining either epicenter or aftershock location. The damage building was interpreted as due to its geologic setting, non engineered building, and close to epicenter of earthquake. This heavily damaged building are located on the Young Merapi sediments at Bantul Regency and lake deposits at Gantiwarno and Bayat area where it can amplify the surface seismic wave. It implies that Peak Ground Acceleration according to Indonesian National Standard should be modified in Yogyakarta area.Keywords: Earthquake, seismic, epicenter, micro-tremor, microzonation
Trends in Biotechnological Development of Agriculture
Authors: Fedorenko V. F. 
Published: October 2019

Modern strategies of biotechnological development are expected to dramatically change not only production processes in agriculture, but the requirements to agricultural infrastructure, and the development strategy of rural territories as well. In the early 2000s, the construction of roads and water pipelines, gasifi cation, sustainable supply of electricity were among the main priorities. But current vital needs include sustainable mobile communication, high-speed Internet, Internet of things, digital technologies, robotics, smart farming etc. Only in this case agricultural production may experience maximum synergetic impact. (Research purpose) Evaluation and determination of the most optimal mechanisms and tools for the development and implementation of the biotechnological capacity of agriculture, working out proposals for consolidating the eff orts of the governement and agribusiness to transform the country into a leading agricultural and food power. (Materials and methods) The author analyzed agricultural development trends in modern conditions; evaluated the eff ectiveness of the processes determining the validity and reasonability of the implementation of innovative, best available, additive, digital, and other technologies in the production process. (Results and discussions) It has been determined that, in recent years, the most popular and sought-after are the technologies, which have ensured the achievement of the maximum synergistic eff ect from natural and biological resources utilized by agricultural producers, farmers and agricultural holdings. These include land, agricultural landscapes, soil biocenoses, water, and genetic productivity resources, i.e. plants, livestock, poultry, aquaculture objects, and other cultivated living organisms used by people, while observing the environmental law and preserving natural environment. (Conclusions) It has been established that modern vectors of biotechnological development radically change not only agricultural production processes, but also the requirements for agricultural infrastructure and the concept of rural area development. Currently, the four main strategies based on the paradigm of maximized utilization of the existing agrobiotechnological resources are considered to be the most vital, sustainable, and promising ones.
Estudio de prevalencia de lesiones por presión en un Hospital Universitario, Bogotá-Colombia
Authors: González Consuegra Renata Virginia , Roa Lizcano Karen Tatiana , López Zuluaga Wilmar José 
Published: October 2019

Objetivo: Determinar la prevalencia de las LPP (Lesiones por presión) en pacientes hospitalizados, entre septiembre y noviembre del año 2016, en un Hospital Universitario de Bogotá, Colombia. Materiales y métodos: Estudio descriptivo, transversal, de prevalencia de periodo que utilizó como instrumento una encuesta elaborada a partir de las directrices del Grupo Nacional para el Estudio y Asesoramiento de Úlceras por Presión y Heridas Crónicas GNEAUPP 2003. Los datos recolectados se obtuvieron a partir de las historias clínicas, valoración de enfermería y preguntas directas. Resultados: Se encontraron 40 pacientes con LPP en 282 camas, para una prevalencia de un 14.1 %; predomina el sexo masculino con un 67.5 %; las edades oscilan entre los 75 y 85 años. El 40 % estaba hospitalizado en medicina interna, la mayoría pertenecía al régimen subsidiado en un 87.5 %. La etiología de la lesión fue de 92.5 % por presión y de un 47.5 % por humedad, clasifi cadas en fases 1 y 2 el 30 %. Se encontraron pacientes con más de dos LPP en un 30 %, la localización más común fue el talón con un 30 %. Se acentúa el desconocimiento sobre el uso de los Ácidos Grasos Hiperoxigenados en las superfi cies especiales para el manejo de la presión. Conclusión: Como resultado se observa que el estudio es similar a otros realizados en el país. Igualmente, se percibe que datos como las características de las LPP, su etiología y las medidas de prevención utilizados en la institución, son la base para el análisis general del fenómeno, ya que permite conocer el comportamiento de las LPP en el contexto nacional. Así mismo, se constituyen en insumos que contribuyen a construir un plan de cuidado integral así como su implementación, a partir de medidas educativas que sensibilicen al equipo de salud sobre la atención segura del paciente.
Tecnologías de la información y comunicación en hipertensión arterial: ensayo clínico controlado
Authors: Díaz Rueda Elvia , Ortiz Suarez Consuelo 
Published: October 2019

Objetivo: Determinar la efectividad de una estrategia de seguimiento telefónico asociado a mensajes de texto en la capacidad de agencia de autocuidado en pacientes con hipertensión arterial, que asistieron a consulta externa en una Clínica de Santander. Metodología: Se realizó un ensayo clínico con pre y post prueba en 130 pacientes hipertensos seleccionados aleatoriamente en dos grupos paralelos: el grupo 1 de intervención recibió la estrategia de seguimiento telefónico más mensajes de texto durante un periodo de dos meses y el grupo 2 de control, fue atendido de forma usual en la consulta externa. A cada grupo se le aplicó la pre y post prueba mediante el cuestionario de capacidad de agencia de autocuidado en el paciente hipertenso, diseñado por Achury et al, con validez y confiabilidad de 0.75, antes y trascurridos 2 meses. Resultados: La capacidad de agencia de autocuidado mediante la estrategia de seguimiento telefónico más mensajes de texto permitió: pasar de media a alta con la intervención aplicada durante los dos meses, se evidenciaron cambios en los estadios de la hipertensión de II a I, mayor conocimiento de la enfermedad y su tratamiento farmacológico, aumento de la actividad física, alimentación saludable y apoyo familiar, lo cual indica que la intervención genera cambios que favorecen el empoderamiento y control del autocuidado. Conclusiones: La estrategia de seguimiento telefónico más mensajes de texto es efectiva al mejorar la capacidad para diligenciar el autocuidado, a su vez permite tener una relación terapéutica enfermera-paciente, ya que el paciente se siente motivado en adquirir conductas de autocuidado favorables.
Congenital heart disease and pregnancy
Authors: Rudaeva E. V. , Mozes V. G. , Kashtalap V. V. , Zakharov I. S. , Yelgina S. I. , Rudaeva E. G. 
Published: October 2019

Annually, there > 30,000 infants are born with congenital heart defects; in different populations, the prevalence of congenital heart disease (CHD) varies from 2.4 to 14.15%. Women with CHD planning pregnancy are at increased risk of heart failure, arrhythmias, cerebrovascular disease, and embolism. In such patients, pregnancy course is complicated by intrauterine growth restriction, pre-eclampsia, and preterm birth. Their newborns generally have a low birth weight and high risk of congenital malformations including heart defects. European Society of Cardiology (ESC) developed risk assessment-based guidelines to optimise the management of pregnant women with CHD. This approach requires a cooperation of obstetrician-gynecologists, general practitioners, and cardiologists.
Major obstetric haemorrhage: portrait of "near miss" and risk management-based optimisation of obstetric techniques and telemedicine technologies
Authors: Remneva O. V. , Ershova E. G. , Chernova A. E. , Galchenko A. I. , Borovko V. A. 
Published: October 2019

Aim. To identify measures for the improvement of obstetric techniques and telemedicine technologies in women with major obstetric haemorrhage.Materials and Methods. We analyzed medical documentation of 54 women in Altai Krai who experienced major obstetric haemorrhage within 28- 36 weeks of gestation before (2008-2012) and after (2013-2017) implementation of risk management using the telemedicine “Registry of pregnancies” technology.Results. Implementation of risk management principles led to the admission of women with major obstetric haemorrhage exclusively to specialised hospitals in contrast to the preceding period. Further, it was associated with a higher prevalence of caesarean sections (from 55.6% to 96.3%) in women with major obstetric haemorrhage due to an increase in cases of complete placenta previa or placenta increta. In 73.0% of cases, such patients delivered in specialised hospitals where autologous blood transfusion or intrauterine balloon tamponade could be applied. In spite of increase in frequency of major obstetric haemorrhages, risk management reduced their severity by decreasing blood loss and, hence, the risk of posthaemorrhagic complications and blood transfusion side effects.Conclusions. Risk management-based strategy for optimising obstetric care by telemedicine technologies leads to the admission of high-risk, even “near miss” patients in specialised hospitals that is particularly efficient in regions with low population density and a large network of primary healthcare facilities.