bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calf Blood Compound (CFC) and Homeopathic Drug Induce Differentiation of Primary Human Skeletal Muscle Cells
Authors: Langendorf Eva K. , Klein Anja , Rommens Pol M. , Drees Philipp , Ritz Ulrike , Mattyasovszky Stefan G. 
Published: September 2019

AbstractThe use of injections to treat structural muscle injuries is controversially discussed. In our controlled in vitro study, we investigated the biological impact of Actovegin and Traumeel alone and in combination on primary human skeletal muscle cells. Cells were characterized by immunofluorescence staining for myogenic factor 5 (Myf5) and MyoD, and cultured with or without Actovegin and / or Traumeel. The effects of these agents were assayed by cell viability and gene expression of the specific markers MyoD, Myf5, neural adhesion molecule (NCAM), and CD31. Myotube formation was determined by myosin staining. Neither Actovegin nor Traumeel showed toxic effects or influenced cell viability significantly. High volumes of Actovegin down-regulated gene expression of NCAM after 3 days but had no effect on MyoD, Myf5, and CD31 gene expression. High volumes of Traumeel inhibited MyoD gene expression after 3 days, whereas after 7 days MyoD expression was significantly up-regulated. The combination of both agents did not significantly influence cell viability or gene expression. This is the first study demonstrating that Actovegin and Traumeel potentially modulate human skeletal muscle cells. The relevance of these in vitro findings has to be highlighted in further in vivo studies.
Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers
Authors: Ramirez-Jimenez Miguel , Morales-Palomo Felix , Ortega Juan Fernando , Mora-Rodriguez Ricardo 
Published: September 2019

AbstractWe studied the effects of supramaximal interval exercise (SIE) with or without antihypertensive medication (AHM) on 21-hr blood pressure (BP) response. Twelve hypertensive patients chronically medicated with AHM, underwent three trials in a randomized order: a) control trial without exercise and substituting their AHM with a placebo (PLAC); b) placebo medicine and a morning bout of SIE (PLAC+SIE), and c) combining AHM and exercise (AHM+SIE). Acute and ambulatory blood pressure responses were measured for 21-hr after treatment. 20  min after treatment, systolic blood pressure (SBP) readings were reduced, similar to readings after PLAC+SIE (−9.7±6.0 mmHg, P<0.001) and AHM+SIE (−10.4±7.9 mmHg, P=0.001). 21 h after treatment, SBP remained reduced after PLAC+SIE (125±12 mmHg, P=0.022) and AHM+SIE (122±12 mmHg, P=0.013) compared to PLAC (132±16 mmHg). The BP reduction in PLAC+SIE faded out at 4 a.m., while in AHM+SIE it continued overnight. At night, BP reduction was larger in AHM+SIE than PLAC+SIE (–5.6±4.0 mmHg, P=0.006). Our data shows that a bout of supramaximal aerobic interval exercise in combination with ARB medication in the morning elicits a sustained blood pressure reduction lasting at least 21-h. Thus, the combination of exercise and angiotensin receptor blocker medication seems superior to exercise alone for acutely decreasing blood pressure.
Arzneimittelsicherheit und Pharmakovigilanz aus Sicht der Arzneimittelkommission der deutschen Ärzteschaft
Authors: Stammschulte Thomas , Köberle Ursula , Peter Hans-Hartmut , Pitzer Martina , Gundert-Remy Ursula 
Published: September 2019

ZusammenfassungSpontanmeldungen von Nebenwirkungen durch Ärzte sind ein wichtiger Baustein der Pharmakovigilanz und tragen dazu bei, dass die Arzneimitteltherapie für Patienten sicherer wird. In Deutschland sind Ärzte durch das Berufsrecht aufgefordert, Nebenwirkungen von Arzneimitteln, die sie bei ihren Patienten beobachten, an die Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ) zu melden. In dem Beitrag wird der Aufbau des deutschen Pharmakovigilanzsystems erklärt und die wichtigsten Informationsquellen für Ärzte zu Nebenwirkungen und Arzneimittelsicherheit erläutert. Anhand von zwei Fallbeispielen aus der Rheumatologie wird dargestellt, wie die AkdÄ bei der Bewertung von Spontanmeldungen vorgeht und was mit den Meldungen im Weiteren passiert.
Genetische Grundlagen der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung
Authors: Grimm Oliver , Kranz Thorsten M. , Reif Andreas 
Published: September 2019

ZUSAMMENFASSUNGDie Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) zeigt eine hohe Erblichkeit in formalgenetischen Studien. Auch im Vergleich zu anderen psychiatrischen Erkrankungen ist die Heritabilität mit fast 80 % sehr hoch. Die Symptomatik der ADHS scheint jedoch graduell in der Normalbevölkerung vorzukommen. Neuere Arbeiten schätzen den Anteil der auf Einzelnukleotidvarianten beruhenden Heritabilität auf 22 %. Welcher Bereich der molekularen Genetik diese Differenz erklärt, ist unklar. In dem vorgelegten Übersichtsartikel geben wir einen Überblick über die Analyse häufiger und seltener Varianten. Während häufige Varianten in ersten Megaanalysen mit vielen tausend Patienten erste genomweite Ergebnisse bringen, die jedoch nur wenig Varianz erklären, zeigen sich die methodisch immer noch schwierigeren Analysen von seltenen Varianten erst in ihren Anfängen. Sie erklären in einigen wenigen individuellen Fällen jedoch eine beträchtliche Varianz. Hierzu werden Beispiele gegeben und diskutiert. Für die Praxis ist die kritische Kenntnis der Genetik der ADHS weder für Therapie noch Diagnostik zwingend. Möglicherweise werden in Zukunft auch seltene Varianten häufiger diagnostiziert werden. Um eine kompetente Beratung zu gewährleisten, ist die Kenntnis des aktuellen Forschungsstandes jedoch auch für den Praktiker von Belang.
Sicherheit von JAK-Inhibitoren
Authors: Leipe Jan 
Published: September 2019

ZusammenfassungDie zugelassenen Januskinase (JAK)-Inhibitoren Baricitinib und Tofacitinib haben bereits das Armamentarium hochwirksamer Therapien bei rheumatoider Arthritis, Psoriasis-Arthritis und Colitis ulcerosa erweitert. Als Alternative zu Biologika unterscheiden sie sich jedoch durch den Wirkmechanismus (Hemmung intrazellulärer Signalübertragung) und die orale Verfügbarkeit. Die Sicherheit ist jedoch ähnlich gut wie bei Biologika, am häufigsten kommen leichtgradige Infekte der oberen Atemwege vor. Verhältnismäßig seltene, aber spezifische Nebenwirkungen stellen Herpes-Zoster-Infektionen dar. Schwere Infektionen werden nur selten beobachtet. Nicht-infektiöse Nebenwirkungen beinhalten Laborwertveränderungen in Form von Zytopenien, Anstieg von Cholesterin (scheinbar ohne Erhöhung des kardiovaskulären Risikos), selten Leber- und Nierenwert-Erhöhungen sowie vermutlich ein erhöhtes Thromboembolie-Risiko bei bestimmten Risikokonstellationen.
Arzneimittelsicherheit bei der Therapie rheumatischer Erkrankungen im Kindes- und Jugendalter – Ergebnisse aus JuMBO
Authors: Klotsche Jens , Niewerth Martina , Minden Kirsten 
Published: September 2019

ZusammenfassungDie juvenile idiopathische Arthritis (JIA) bedarf insbesondere bei schweren Verläufen zur Vermeidung von Folgeschäden und dauerhaften Funktionseinbußen einer konsequenten Therapie. Biologika gewinnen hier zunehmend an Bedeutung. Über deren Wirksamkeit und Sicherheit in der klinischen Routineversorgung informieren die Biologika-Register BiKeR und JuMBO. JuMBO, als Follow-up-Register von BiKeR, liefert aufgrund der Weiterbeobachtung der Patienten im Erwachsenenalter wichtige Informationen zur Langzeitsicherheit von Biologika und zum Langzeit-Outcome der JIA.Die Daten des JuMBO-Registers bestätigen im Allgemeinen die gute Verträglichkeit der Biologika in der Langzeitanwendung. Schwere unerwünschte Arzneimittelnebenwirkungen werden selten dokumentiert, neu aufgetretene Autoimmunerkrankungen beschränken sich bisher auf wenige Einzelfälle. Ein Schwerpunkt der Sicherheitsanalysen liegt in der Kalkulation der Malignomrate bei DMARD-exponierten JIA-Patienten. Die bisher in JuMBO erfassten Fälle ließen kein erhöhtes Risiko bei Biologika-exponierten im Vergleich zu nur MTX-exponierten Patienten erkennen. Aber mit den bisher 12 gemeldeten Fällen liegt die Malignomrate in JuMBO über der in der Bevölkerung. Aufgrund der geringen Fallzahlen, der teilweisen DMARD-Mehrfachexposition dieser Patienten und der potenziellen Risikoerhöhung durch eine langanhaltende hohe Krankheitsaktivität sind die Daten jedoch mit Vorsicht zu interpretieren. Eine abschließende Beurteilung des Malignomrisikos unter Biologika-Therapie ist mit den vorliegenden Daten nicht möglich. Eine konsequente Nachbeobachtung der jungen Rheumatiker im JuMBO-Register ist unbedingt nötig, um notwendige Informationen zur Therapiesicherheit bei der JIA zu gewinnen.
Transcervical Mediastinoscopic Closure of Left-Sided Postpneumonectomy Bronchial Stump Fistula
Authors: Paleru Cristian , Cordoş Ioan , Dănăilă Olga , Bolca Ciprian 
Published: September 2019

Introduction This article presents a series of patients on which the transcervical approach was used to close a left-sided postpneumonectomy fistula.Materials and Methods The series comprises nine patients with a left pneumonectomy performed for a tuberculosis-related suppurative disease in five cases and for lung cancer in the remaining four. This procedure can be performed under certain conditions, the most important one being the length of the bronchial stump, which should be at least 1 cm, ideally 1.5 cm. The transcervical stump closure was successfully achieved in all patients, having been more technically demanding in cancer cases with previous lymphadenectomy. The postpneumonectomy infected cavity was subsequently treated.Results The follow-up continued for at least 1 year; one individual from the cancer patients group died from an uncontrolled sepsis during the postoperative period, another one died 17 months later from metastatic cancer and two of them are alive, with no signs of neoplastic or infectious relapse 15 and 37 months, respectively, after the cervical procedure. One patient from the suppurative disease group had a relapse of the fistula 2 months after surgery, requiring additional surgical procedures to deal with this issue; all the other patients are alive, with no signs of recurrence.Conclusions The transcervical approach is a very suitable maneuver in selected patients with a bronchial stump at least 1 cm long, ideally 1.5 cm.
Resonant tunnelling spectroscopy of van der Waals heterosystems
Authors: Vdovin Evgenii E. , Novoselov Konstantin S. , Khanin Yurii N. 
Published: September 2019

The review concerns the most interesting aspects of (mainly experimental) resonance tunnelling spectroscopy studies of a new type of heterosystems called van der Waals heterostructures. The possibility to compose such systems is a result of the recent discovery of two-dimensional crystals, a new class of materials derived from graphene. The role of the angular mismatch of the crystal lattices of conductive graphene electrodes in the tunnelling of charge carriers between them, as well as the closely related issues associated with fulfillment of the conservation laws during tunnelling transitions are considered. The experimental results on inelastic tunnelling in the graphene/h-BN/graphene heterosystems with strong angular mismatch are discussed. The experiments made it possible to determine the phonon density of states spectra of the constituent layers and to detect and describe tunnelling transitions involving localized states of structural defects in the h-BN barrier. We consider new results of studies on tunnelling and magnetotunnelling in van der Waals heterosystems that demonstrate the possibilities of practical application of resonant tunnelling effects in, e.g., microwave engineering, based on realization of electronic devices having I – V curves with negative differential conductance (NDC) regions at tunnelling through defect levels of the barrier layers in such systems. These studies revealed two new types of heterosystems characterized by the formation of NDC regions as a result of resonant tunnelling through the defect levels in the h-BN barrier and by defect-assisted generation of tunnelling current.
The bibliography includes 40 references.
Critical configurations of solid bodies and the Morse theory of MIN functions
Authors: Ogievetsky O. V. , Shlosman S. B. 
Published: September 2019

Abstract
This paper studies the manifold of clusters of non-intersecting congruent solid bodies, all touching the central ball

of radius one. Two main examples are clusters of balls and clusters of infinite cylinders. The notion of critical cluster is introduced, and several critical clusters of balls and of cylinders are studied. In the case of cylinders, some of the critical clusters here are new. The paper also establishes criticality properties of clusters introduced earlier by Kuperberg.
Multipath interference from large trapped ion chains
Authors: Obšil P , Lešundák A , Pham T , Araneda G , Čížek M , Číp O , Filip R , Slodička L 
Published: September 2019

Abstract
The demonstration of optical multipath interference from a large number of quantum emitters is essential for the realization of many paradigmatic experiments in quantum optics. However, such interference remains still unexplored as it crucially depends on the sub-wavelength positioning accuracy and stability of all emitters. We present the observation of controlled interference of light scattered from strings of up to 53 trapped ions. The light scattered from ions localized in a harmonic trapping potential is collected along the ion crystal symmetry axis, which guarantees the spatial indistinguishability and allows for an efficient scaling of the contributing ion number. We achieve the preservation of the coherence of scattered light observable for all the measured string sizes and nearly-optimal enhancement of phase sensitivity. The presented results will enable realization and control of directional photon emission, direct detection of enhanced quadrature squeezing of atomic resonance fluorescence, or optical generation of genuine multi-partite entanglement of atoms.
Comparison of DSSP and tSSS algorithms for removing artifacts from vagus nerve stimulators in magnetoencephalography data
Authors: Cai Chang , Kang Huicong , Kirsch Heidi E , Mizuiri Danielle , Chen Jessie , Bhutada Abhishek , Sekihara Kensuke , Nagarajan Srikantan S 
Published: September 2019

Abstract

Objective. Large-amplitude artifacts from vagus nerve stimulator (VNS) implants for refractory epilepsy affect magnetoencephalography (MEG) recordings and are difficult to reject, resulting in unusable data from this important population of patients who are frequently evaluated for surgical treatment of epilepsy. Here we compare the performance of two artifact removal algorithms for MEG data: dual signal subspace projection (DSSP) and temporally extended signal space separation (tSSS). Approach. Each algorithm’s performance was first evaluated in simulations. We then tested the performance of each algorithm on resting-state MEG data from patients with VNS implants. We also examined how each algorithm improved source localization of somatosensory evoked fields in patients with VNS implants. Main results. DSSP and tSSS algorithms have a similar ability to reject interference in both simulated and real MEG data if the origin location for tSSS is appropriately set. If the origin set for tSSS is inappropriate, the signal after tSSS can be distorted due to a mismatch between the internal region and the actual source space. Both DSSP and tSSS are able to remove large-amplitude artifacts from outside the brain. DSSP might be a better choice than tSSS when the choice of origin location for tSSS is difficult. Significance. Both DSSP and tSSS algorithms can recover distorted MEG recordings from people with intractable epilepsy and VNS implants, improving epileptic spike identification and source localization of both functional activity and epileptiform activity.
Analysis of vibration characteristics of mounting plate for molded case circuit breaker
Authors: Pan Ying , Tang Zhixian , Cheng Zhi 
Published: September 2019

Abstract
This paper presents a framework to analyze the vibration characteristics of mounting plates for molded case circuit breakers (MCCB). Two different three-dimensional models for mounting plate I and II are established in ANSYS Workbench simulation platform through reasonable simplifications. The preceding six-order natural frequencies are obtained by means of modal analysis. Based on the experimental data of modal analysis, random vibration analysis of mounting panel I and II is conducted. It is concluded that mounting plate I is easy to deform permanently when its 3δ stress exceeds the yield limit of material, while mounting plate II meets the strength requirements and is better suited to test requirements.
A MATLAB post-process method of vehicle cold start data
Authors: Qian Feng , Li Peng , Zhu Neng , Xu Xiaowei 
Published: September 2019

Abstract
Gasoline vehicle cold start calibration is one of the important calibration work content. And the important evaluation criterion of cold start is start time, overshoot, undershoot. At present, the calibration engineers in most companies mainly use ETAS/INCA software to record test data, and then use MDA software to analyse start time, overshoot and undershoot. But the cold start test data is so huge, so the post-processing efficiency is very low. Facing this problem, the post-processing tool of cold start data based on MATLAB is established. With this tool, the huge amount of data can be processed efficiently, and key start mode or start-stop mode can be distinguished clearly. So it can greatly improve the post-processing efficiency of cold start data.
Monitoring the spontaneous combustion of coal stack based on ZigBee and LabView
Authors: Zheng Yu , Lv Fang , Li Deqin , Gao Bingqian 
Published: September 2019

Abstract
The spontaneous combustion of coal piles is a great threat to all coal storage sites. In order to avoid the occurrence of spontaneous combustion of coal piles and reduce economic losses and casualties, a set of system is designed to monitor the internal temperature of coal piles and predict the temperature value and combustible gas concentration. The system has the advantages of monitoring and warning, short-term prediction and low power consumption.
Optimization the first frequency modal shape of a tensural displacement amplifier employing flexure hinge by using Taguchi Method
Authors: Vu Ngoc Chien , Huynh Ngoc Thai , Huang Shyh Chour 
Published: September 2019

Abstract
The high amplification ratio, high frequency, and larger workspace always ask in compliant mechanisms. Thus, in this investigation optimized design dimension to select an optimal model for a tensural displacement amplifier employing flexure hinge by utilizing Taguchi method based on finite element analysis (FEA). The Solidworks software was applied to design the model, the first modal shape frequency was gained by FEA in ANSYS. The orthogonal L27 was applied to design 27 experiments. The data was collected from 27 cases which were analyzed by signal to noise, ANOVA and regression analysis (RA). The simulation results indicated that thickness of flexure hinge (TOFH) made significant increasing the 1st natural frequency when its rises from 0.3 mm to 0.7 mm and decreased as incline angle between two flexure hinges rises from 00 to 0.50. The phenomena also confirmed by S/N analysis, ANOVA and RA. The optimal value of the frequency obtained 214.06 Hz is good agreement with the forecasted value of 198.1758 Hz with deviation error of 7.15%.
Development of foreign matter removal robot for overhead transmission lines
Authors: Zhang Yaodong , Li Jinbin , Li Cheng , Tao Qian , Xiong Xiaomin 
Published: September 2019

Abstract
In recent years, the limitations of artificial live working have become increasingly prominent. Researching robot technology that replaces manual work has become an important branch of intelligent research on power maintenance. In this paper, the objects and tasks of foreign matter removal in overhead transmission lines are analyzed. The structure of the robot is introduced, and the control method and software design of the robot system are described. The test and field application show that the robot is reliable, stable and easy to control. It can remove floating foreign matters on the overhead line, meet the requirements of live working of the transmission line, and can replace the manual removal of foreign objects.
Research in Torque Distribution of Dual Motor Electric Vehicle Based on PSO
Authors: Xie Jinfa , Liu Han , Li Bochao , Xie Ning 
Published: September 2019

Abstract
This paper proposed real-time optimization algorithm in order to solve the problem which the dynamic nonlinear torque distribution of rear dual-hub-motor-driven vehicle. Based on the research of a company’s rear-wheel drive double-wheel hub motor, build the control model by MATLAB, the vehicle model set up by CarSim, and Co-simulation test the performance of algorithm. Then hardware-in-loop test based on the VCU. The result shown that the algorithm could distributed torque according to the actual working conditions, reduced the slip ratio, improved the driving performance of vehicle.
Numerical simulation of surface diffusion motion and its application in MEMS fabrication
Authors: Zhang Yujie , Zeng Fan , Wong Man , Xiang Junping , Ye Wenjing 
Published: September 2019

Abstract
Surface diffusion motion has been proposed as a new technique, called Silicon Migration Technology (SiMiT) for the fabrication of Micro-Electro-Mechanical System (MEMS) devices. Using this new technology, the integration of MEMS-CMOS can be achieved without the “sacrificial-structural” layers and “release-etch” procedure, which are necessary in traditional approaches. However, numerical simulation of surface diffusion process is still a challenging task due to the stiffness nature and the topological changes during the process. In this paper, we adopted a high-order explicit level-set method based on the total variation diminishing Runge-Kutta (TVD-RK) method, a high-order scheme for distance computation. An efficient smoothing scheme is proposed to increase the numerical stability and an adaptive time marching scheme is developed to accelerate the simulation. Experimental investigation of shape transformation of silicon trenches is carried out to verify the accuracy of the numerical scheme. Results show that numerical simulation results match quite well with experimental ones, which suggests the accuracy and reliability of the numerical simulation in the application of MEMS design.
Analysis of cracking causes of micro-spray desuperheater for 1025T/H boiler reheater
Authors: Pang Linya , Yang Qingxu , Feng Lizhong , Yang Xianbiao , Liu Xubi 
Published: September 2019

Abstract
A power plant 1025t/h boiler reheater micro-spray desuperheater fixed desuperheating water nozzle tube fillet weld cracking, after inspection and test, analyzed the cause of cracks. The analysis concluded that the welding quality of the end cap of the sprinkler is poor, and the plug weld has a leak point. During the desuperheater operation, the leaked desuperheating water is directly sprayed on the desuperheater cylinder, the fixed stem and the nearby mother. A large number of thermal fatigue cracks are generated under the action of alternating thermal stress, and gradually expand into penetrating cracks under the environment of long-term high temperature and high pressure. In order to avoid the recurrence of similar cracking leakage, it is recommended to replace the failed desuperheater and check the same parts of other desuperheaters and at the same time strengthen the supervision of the desuperheater installation quality.