bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predation risk and microhabitat selection by cave salamanders, Eurycea lucifuga (Rafinesque, 1822)
Authors: Bradley J. Gavin , Eason Perri K. 
Published: August 2018

Abstract
Habitat selection is driven by many factors, but no one location is likely to be best for all factors; thus, individuals are subject to trade-offs when selecting habitat. Caves provide a clear example of such trade-offs because these habitats are energy deprived. Cave salamanders (Eurycea lucifuga) commonly inhabit caves at least in part because this habitat is cool and wet. We tested the hypothesis that caves also provide cave salamanders with a reduction in predation risk. We used clay models to test for differences in predation risk in caves vs. forests and at low (e.g., ground) vs. elevated (e.g., cave wall) positions, and recorded locations of cave salamanders to assess vertical (i.e., wall) vs. non-vertical (e.g., ground) substrate selection in a cave. Overall, a mean of 3.2 models in caves were damaged and a mean of 8.2 were damaged in forests. Cave salamanders selected vertical substrate more often than non-vertical substrate (, ), and in caves, low-positioned models were more likely to be damaged than models on walls, although there was no effect of model height in forests. This study suggests that caves provide salamanders a refuge from increased predation pressure, a benefit that likely compensates for the costs of moving between caves and the richer foraging grounds outside them.
Description of Basilaphelenchus brevicaudatus n. sp. (Aphelenchoidea: Tylaphelenchinae) from a dead forest tree in northern Iran
Authors: Mirzaie Fouladvand Zeinab , Pourjam Ebrahim , Kanzaki Natsumi , Giblin-Davis Robin M. , Pedram Majid 
Published: August 2018

Summary
Basilaphelenchus brevicaudatus n. sp., the third species of this apparently rare genus, is described and illustrated. It was recovered from wood and bark samples from a dead forest tree in the Golestan province of northern Iran. It is typologically characterised by female body length (448 (365-492) μm), three lines in the lateral fields, raised cephalic region having a sclerotised vestibule and cephalic framework, stylet thin with delicate conus and thicker shaft, both parts lacking a visible lumen, and with three elongate, backwardly directed knobs, small, spherical to spade-shaped metacorpus with small, posteriorly located valve (at 72 (58-74)% of metacorpus length), simple vulva without flap at 72.5 (69-78)% of body length, post-vulval uterine sac 32.4 (29.0-37.0) μm long, functional rectum and anus, female tail conical, short (c′ = 2.6 (1.9-3.3) in female, and 2.5 (2.3-2.8) in male), dorsally convex and ventrally concave with blunt end or having a small mucron, both forms with a hyaline-like tip. Males common, with well-curved 9.2 (9.0-10.5) μm long spicules measured along the mid-line, three pairs of small caudal papillae (lacking the single P1 ventral papilla) and no bursa at tail tip, but with hyaline region, similar to females. Basilaphelenchus brevicaudatus n. sp. is compared with the two currently known species of the genus, the type species, B. persicus, and B. grosmannae. Molecular phylogenetic inferences using partial sequences of small and large subunit ribosomal RNA genes (SSU and LSU) from different isolates of the new species revealed that it belongs to the Tylaphelenchinae clade.
Plotinus on Light and Vision
Authors: Gurtler Gary M. 
Published: August 2018

AbstractEnnead IV 5[29] has been poorly served by translators and commentators, misreporting what Plotinus wrote and, with these mangled results, asserting that this part of his treatise on the “Problems about the Soul” is merely a disjointed series of doxographical fragments with little compelling contribution to make. More careful translation and analysis reveal something strikingly different and original. First, he gives a cogent critique of the theories of Plato and Aristotle concerning the body between and the role of daylight. Second, he substitutes his own account in terms of both sympathy and the principle of two acts, explaining vision both during the day as well as at night, notably deficient in previous accounts. Third, he derives some surprisingly original corollaries about the nature of light and the source of color.
Finescale Assessment of Mobile Home Tornado Vulnerability in the Central and Southeast United States
Authors: Strader Stephen M. , Ashley Walker S. 
Published: August 2018

Abstract
Research has illustrated that tornado disaster potential and impact severity are controlled by hazard risk and underlying physical and social vulnerabilities. Previous vulnerability studies have suggested that an important driver of disaster consequence is the type of housing affected by tornadic winds. This study employs a Monte Carlo tornado simulation tool; mobile home location information derived from finescale, land-parcel data; and census enumerations of socioeconomic vulnerability factors to assess the tornado impact probability for one of the most wind hazard–susceptible demographics in the United States: mobile home residents. Comparative analyses between Alabama and Kansas are employed to highlight regional (i.e., Southeast vs Great Plains) differences in mobile home tornado risk, exposure, and vulnerability. Tornado impact potential on mobile homes is 4.5 times (350%) greater in Alabama than in Kansas because Alabama, in comparison to Kansas, is represented by 1) a greater number of mobile homes and 2) a more sprawling mobile home distribution. Findings reveal that the Southeast’s mobile home residents are one of the most socioeconomically and demographically marginalized populations in the United States and are more susceptible to tornado impact and death than illustrated in prior research. Policy makers, engineers, and members of integrated warning teams (i.e., National Weather Service, media, emergency managers, and first responders) should use these findings to initiate a dialogue and construct interdisciplinary actions aimed at improving societal and individual resilience before, during, and after hazardous weather events.
Self-Management of HIV and Diabetes in African American Women: A Systematic Review of Qualitative Literature
Authors: Zuniga Julie A. , Wright Charlotte , Fordyce Jonathan , West Ohueri Chelsi , Garciá Alexandra A. 
Published: August 2018

Purpose The purpose of this systematic review of qualitative literature was (1) to identify self-management strategies, (2) to identify women’s barriers to self-management, and (3) to compare self-management strategies of diabetes and human immunodeficiency virus (HIV). African American women living with HIV are at high risk for developing diabetes because of genetics, lifestyle, and HIV treatment. Self-management of each of these conditions is critical to decrease morbidity and mortality. Conclusions A literature search resulted in 15 articles: 10 on the topic of HIV and 5 on diabetes. Self-management strategies included spirituality, family and social support, and indulgent self-care. Barriers included depression, stigma, and the role of caregiver. The themes identified for HIV and diabetes self-care barriers and facilitators were exceptionally similar. Themes of spirituality, family support, and indulgent self-care were part of both HIV and diabetes self-care. Women with HIV were less concerned with their independence than women with diabetes, and focused on disclosure of their HIV status and development of a support system.
The role of radiotherapy in elderly women with early-stage breast cancer treated with breast conserving surgery
Authors: Valli Mariacarla , Cima Simona , Fanti Paola , Muoio Barbara , Vanetti Alessandra , Azinwi Che N. , Yordanov Kaloyan , Martucci Francesco , Pesce Gianfranco A. , Canonica Claudia , Richetti Antonella 
Published: August 2018

Objective: To analyze the impact of adjuvant radiotherapy (RT) on ipsilateral breast recurrence (IBR) and overall survival (OS) in patients older than 69 years with early-stage breast cancer. Methods: From January 2007 to June 2015, we analyzed retrospectively 137 women with estrogen receptor–positive T1–2 invasive breast cancer, with negative axillary lymph nodes, dividing them into 2 subgroups: 70 to 79 years and older than 79 years. Results: After a median follow-up of 43.2 months, the 3-year IBR-free survival in patients treated with surgery plus RT was 98.8% and 92.1% in patients treated with surgery alone, with a significant difference ( p = .01). Radiotherapy did not impact overall survival ( p = .10). A higher percentage of patients aged between 70 and 79 years received RT after conservative surgery if compared with the older subgroup ( p < .01). Conclusions: In elderly women, adjuvant RT reduced the IBR, but did not improve OS.
Management of Recurrent Anterior Shoulder Instability With Bipolar Bone Loss: A Systematic Review to Assess Critical Bone Loss Amounts
Authors: Gowd Anirudh K. , Liu Joseph N. , Cabarcas Brandon C. , Garcia Grant H. , Cvetanovich Gregory L. , Provencher Matthew T. , Verma Nikhil N. 
Published: August 2018

Background: There is increasing evidence to suggest that the amount of glenoid bone loss to indicate bone block procedures may be lower than previously thought, particularly in the presence of a Hill-Sachs defect. Purpose: To better establish treatment recommendations for anterior shoulder instability among patients with bipolar bone lesions. Study Design: Systematic review and meta-analysis; Level of evidence, 4. Methods: A systematic review of the literature was performed with PubMed, EMBASE, Cochrane Library, and Scopus databases according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. Studies evaluating outcomes of operative management in anterior shoulder instability that also reported glenoid bone loss in the presence of Hill-Sachs defects were included. Recurrence rates, glenoid bone loss, and humeral bone loss were pooled and analyzed with forest plots stratified by surgical procedure. Methods of quantification were analyzed for each article qualitatively. Results: Thirteen articles were included in the final analysis, with a total of 778 patients. The mean ± SD age was 24.9 ± 8.6 years. The mean follow-up was 30.1 months (range, 11-240 months). Only 13 of 408 (3.2%) reviewed bipolar bone loss articles quantified humeral and/or glenoid bone loss. Latarjet procedures had the greatest glenoid bone loss (21.7%; 95% CI, 14.8%-28.6%), followed by Bankart repairs (13.1%; 95% CI, 9.0%-17.2%), and remplissage (11.7%; 95% CI, 5.5%-18.0%). Humeral bone loss was primarily reported as percentage bone loss (22.2%; 95% CI, 13.1%-31.3% in Bankart repairs and 31.7%; 95% CI, 21.6%-41.1% in Latarjet) or as volumetric defects (439.1 mm3; 95% CI, 336.3-541.9 mm3 in Bankart repairs and 366.0 mm3; 95% CI, 258.4-475.4 mm3 in remplissage). Recurrence rates were as follows: Bankart repairs, 19.5% (95% CI, 14.5%-25.8%); remplissage, 4.4% (95% CI, 1.3%-14.0%); and Latarjet, 8.7% (95% CI, 5.0%-14.7%). Bankart repairs were associated with significantly greater recurrence of instability in included articles ( P = .013). Conclusion: There exists a need for universal and consistent preoperative measurement of humeral-sided bone loss. The presence of concomitant Hill-Sachs defects with glenoid pathology should warrant more aggressive operative management through use of bone block procedures. Previously established values of critical glenoid bone loss are not equally relevant in the presence of bipolar bone loss.
A Brain-Based Instruction Simulation Approach to Improve Code Team Response in an Internal Medicine Unit
Authors: Clapper Timothy C. , Rajwani Kapil , Mauer Elizabeth , Gerber Linda M. , Lee Joanna , Ching Kevin , Miller Stephanie , Gudi Kirana 
Published: August 2018

Background and Objectives. The code team course is a 3-hour, interactive course that follows a 4-phase brain-based lesson plan for simulation. Interprofessional teams receive instruction and practice in evidence-based teamwork, communication, and individual skills. Methods. This quantitative research included a pre-test and post-test design in an urban Department of Medicine. Sixteen groups (n=109) participated in the course over a period of eight weeks. Classroom metrics included pre- and post-course High-Quality cardiopulmonary resuscitation (CPR) and code team didactic knowledge assessed by Wilcoxon rank-sum tests. In addition, four in-situ mock code simulations were conducted to provide the researchers with baseline and post-intervention data. Code team performance assessment scores were tallied and compared between baseline and post-intervention by Fisher’s Exact Test. Results. The classroom metrics produced significant results. High-Quality CPR scores were higher post-training than pre-training (median score 4 vs. 3, respectively; p=0.006). Didactic knowledge test scores were also significantly higher (median score 90 vs. 70, respectively; p <0.001). In-situ team performance improved in several areas. There was a significant improvement in the area of cardiac code management in the day shift group. The percent “done well” improved from 25% (5/20) to 100% (20/20) (p= <0.001). Conclusion. The results of this pilot study suggest that code team training using the 4-phase BBL plan for simulation is associated with improvements in interprofessional team knowledge and performance during cardiac emergencies. It is equally important that the training is conducted over a short period in order to ensure that all team members are properly prepared.
Prognostic Role of Neutrophil to Lymphocyte Ratio in Ovarian Cancer: A Meta-Analysis
Authors: Chen Gaowen , Zhu Lin , Yang Yulu , Long Yusheng , Li Xiangyuan , Wang Yifeng 
Published: August 2018

Objective: The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to analyze the association of pretreatment neutrophil to lymphocyte ratio with overall survival and progression-free survival. Methods: We performed a systematic literature research of PubMed, EMBASE, Medline, and Cochrane library for relevant studies up to October 8, 2017. The quality of included studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The hazard ratio and corresponding 95% confidence intervals were calculated. We checked the heterogeneity by the Q test and Higgins I-squared statistic. Begg funnel plot and Egger linear regression test were also applied for ascertain publication bias. All of the statistical analyses were performed using STATA version 12.0. Results: A total of 12 studies with 4046 patients were included in our study. The results indicated that depressed neutrophil to lymphocyte ratio was significantly correlated with higher overall survival (hazard ratio = 1.409, 95% confidence intervals = 1.112-1.786, P = .005) and progression-free survival (hazard ratio = 1.523, 95% confidence intervals = 1.187-1.955, P = .001) in ovarian cancer. Subgroup analysis by ethnicity of overall survival and progression-free survival showed that the prognostic effect of neutrophil to lymphocyte ratio was found both in Asians and Caucasians. Conclusion: Patients with depressed neutrophil to lymphocyte ratio had a higher overall survival and progression-free survival in ovarian cancer. This meta-analysis provided neutrophil to lymphocyte ratio as an available predictor of overall survival and progression-free survival for patients with ovarian cancer.
P2X4-receptor participates in EAAT3 regulation via BDNF-TrkB signaling in a model of trigeminal allodynia
Authors: Liu Chaoyang , Zhang Yixin , Liu Qing , Jiang Li , Li Maolin , Wang Sha , Long Ting , He Wei , Kong Xueying , Qin Guangcheng , Chen Lixue , Zhang Yuhong , Zhou Jiying 
Published: August 2018

Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little is known about its role in inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. Here, we determined the contributions of P2X4R and related signaling pathways in an inflammatory soup-induced trigeminal allodynia model. Methods P2X4R gene and protein levels in the trigeminal nucleus caudalis were analyzed following repeated dural inflammatory soup infusions. p38, brain-derived neurotrophic factor, excitatory amino acid transporter 3, c-Fos, and calcitonin gene-related peptide protein levels in the trigeminal nucleus caudalis, as well as trigeminal sensitivity, were assessed among the different groups. Immunofluorescence staining was used to detect protein localization and expression in the trigeminal nucleus caudalis. Results Repeated inflammatory dural stimulation induced trigeminal hyperalgesia and the upregulation of P2X4R. Immunofluorescence revealed that P2X4R was expressed in trigeminal nucleus caudalis microglial cells. Blockage of P2X4R produced an anti-nociceptive effect, which was associated with an inhibition of inflammatory soup-induced increases in p38, brain-derived neurotrophic factor, excitatory amino acid transporter 3, c-Fos, and calcitonin gene-related peptide protein levels. The tyrosine receptor kinase B antagonist ANA-12 reversed trigeminal allodynia and the upregulation of excitatory amino acid transporter 3, c-Fos, and calcitonin gene-related peptide, whereas the agonist 7,8-dihydroxyflavone exacerbated these effects. Double immunostaining indicated that p38 and brain-derived neurotrophic factor were mainly expressed in microglial cells, whereas excitatory amino acid transporter 3 was primarily expressed in trigeminal nucleus caudalis neurons. Conclusions These data indicate that microglial P2X4R is involved in the regulation of excitatory amino acid transporter 3 via brain-derived neurotrophic factor-tyrosine receptor kinase B signaling following repeated inflammatory dural stimulation. Microglial P2X4R activation and microglia–neuron interactions in the trigeminal nucleus caudalis may play a role in the pathogenesis of migraine chronicity, and the modulation of P2X4R activation might be a potential therapeutic strategy.
Surgical, Radiologic, and Histologic Findings of the Antrochoanal Polyp
Authors: Chung Seung-Kyu , Chang Byung-Chan , Dhong Hun-Jong 
Published: August 2018

Background Of 15 patients with primary unilateral antrochoanal polyps (ACPs), we noticed that all ACPs except one extended through the accessory ostium of the maxillary sinus projected posterior along the nasal cavity. We observed no structural changes in ostiomeatal area on a coronal computed tomography scan. Methods We classified 15 patients with ACP into three stages according to the coronal computed tomography findings of (i) status of the accessory ostium of the maxillary sinus and (ii) level of extension to the nasopharynx. The extent of inflammation in the computed tomography and histologic aspects were also evaluated according to such stages. Results In three patients, ACPs did not extend to the nasopharynx (stage I). Among the other ACPs reaching the nasopharynx, complete occlusion of the opening (stage II) was noted in seven patients, and partial occlusion of the opening (stage III) was noted in five patients. The extent of ipsilateral, as well as bilateral, inflammation in the imaxillary sinus in stages I and II was greater than that in stage III. More severe inflammatory cell infiltration was observed in stage II in histologic examination. Conclusions We hypothesize that stage I may correspond to an early stage, stage II to full-blown disorder, and stage III to a regression stage. When the exit site of an ACP is the accessory ostium, this opening should be connected to the natural ostium of the maxillary sinus to prevent a possible recirculation phenomenon.
The Endoscopic Modified Lothrop: Long-Term Follow-Up on 44 Patients
Authors: Schlosser Rodney J. , Zachmann Gregory , Harrison Scott , Gross Charles W. 
Published: August 2018

Background The gold standard for surgical treatment of chronic frontal sinusitis has been the osteoplastic flap with obliteration. In an attempt to preserve the frontal sinus, we have been performing the endoscopic modified Lothrop or frontal drill-out. Methods Retrospective chart review. Results We performed the modified Lothrop on 54 patients between 1993 and 1998. The modified Lothrop was successful (no revision surgeries and only an occasional need for antibiotics) after one procedure in 68% (30/44) of patients followed up for ≥1 year. Six patients underwent successful revision, bringing the overall success rate to 82% (36/44). Eight patients (18%) eventually underwent osteoplastic flap with obliteration, three of those after attempted revision. Mean follow-up was 40 months with failures occurring a mean of 12 months after initial Lothrop. Overall complication rate was 11%. Conclusions The modified Lothrop is a technically challenging operation that provides an acceptable alternative to the osteoplastic flap with obliteration.
Multiplanar Reconstructed Computed Tomography Images Improves Depiction and Understanding of the Anatomy of the Frontal Sinus and Recess
Authors: Kew Jacqueline , Rees Guy L. , Close David , Sdralis Theo , Sebben Ruben A. , Wormald Peter-John 
Published: August 2018

Aims The use of multiplanar reconstructed computed tomography (CT) images of frontal recess and sinuses was assessed with regard to depiction and understanding of anatomy and effect on surgical approach. Materials and Methods Three otorhinolaryngologists and one radiologist read CT scans of 43 patients referred for routine paranasal sinus scans. Spiral (helical) CT scans were obtained and coronal and parasagittal reconstructions were imaged. Three hundred forty-two readings were analyzed. The scans were assessed in the coronal plane and then in the parasagittal plane. The images were assessed for (i) Bent and Kuhn classification of frontal ethmoidal sinus air cells, (ii) size of frontal sinus ostium (assessed as unsure, normal, small, or large), (iii) use of parasagittal scans regarding additional understanding of the anatomy with particular reference as to how the agger nasi cell and frontal ethmoidal cells were arranged in a three-dimensional space, and (iv) if the parasagittal scan and subsequent three-dimensional picture created altered the surgical approach. The first two criteria were assessed in the coronal plane and then in the parasagittal plane. Results There was no statistically significant difference between the Bent and Kuhn classification of frontoethmoidal cells on coronal and reconstructed parasagittal images (t-test; p < 0.05). The parasagittal scans were significantly better than the coronal scans for identifying and assessing the size of the frontal sinus ostium (p > 0.001; chi-square test). Assuming an intraobserver change rate (repeat error) of 10% on CT scan observations, an exact binomial test was performed on S-PLUS, which showed that there was a significant (p < 0.001) proportion of observers who changed their rating after looking at the parasagittal scan. There also was significant improvement in observers’ abilities to identify and classify the size of the frontal ostium as reflected by the number of observers who changed from being unsure on the coronal scans to sure on the parasagittal scans. Observers felt that the parasagittal scans improved their three-dimensional understanding of the anatomy of the frontal recess by 58% on a 10-point Lickert scale. In 55% of these observations, the surgical plan was altered by a mean of 70.2% on a 10-point Lickert scale based on additional information obtained by viewing the parasagittal scans. Conclusions The three-dimensional understanding of the frontal recess is improved greatly by using both coronal and parasagittal reconstructed images as compared with coronal images alone. This had important implications on the planning of the surgery in the frontal recess.