bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mandibular, hyoid, and hypobranchial musculature in skates (Chondrichthyes: Batoidea: Rajiformes): revised terminology and phylogenetic implications
Authors: Soares Karla D A 
Published: November 2024

Abstract
About 300 valid species are classified within the order Rajiformes, the largest group of chondrichthyans. The monophyly of this order is highly supported by morphological and molecular inferences, but little is known about the mandibular, hyoid, and hypobranchial muscles of its members. This study aims to describe and illustrate the morphological variation in mandibular, hyoid, and hypobranchial muscles among rajiforms, review their terminology and discuss the phylogenetic and functional implications of conditions observed. Twenty-two ethanol-preserved specimens belonging to 19 of the 36 skate genera currently considered valid were manually dissected. Nine new characters are proposed and tested cladistically. The main differences observed are the relative width of muscle units of the levator palatoquadrati, insertion point and extension of the intermanibularis posterior, relative position of the facialis nerve and the levator hyomandibularis muscle, origin and insertion of the coracomandibularis, extension of the coracohyomandibularis, and occurrence of the preorbitalis medialis and intermandibularis anterior. When analysed together with other morphological features, muscle characters have shown to play a key role in the understanding of interrelationships among skates. Nevertheless, additional studies are needed to improve our knowledge of rajiform systematics and the functionality of mandibular, hyoid, and hypobranchial muscles.
Systematic Review of Obstetric and Child Outcomes of Prenatal Exposure to Inhalants in the Context of a Use Disorder
Authors: Kounlavong Emily Southida , Schauberger Charles W. , Conklin Jamie L. , Jones Hendree E. 
Published: November 2024

Objectives
Inhalants are often used for their psychoactive effects, producing feelings of euphoria. Inhalant and solvent use is a serious public health concern, yet little is known about their effects on perinatal, fetal, and child outcomes. The aim of our review is to evaluate the impact of inhalant use by pregnant people on maternal, fetal, neonatal, and early childhood outcomes.

Methods
A systematic review was conducted on March 1, 2023, in 6 databases using relevant keywords. Bias assessment was performed using JBI Critical Appraisal Tools. Studies were included if they described a prenatal exposure to an inhalant; focused on maternal, fetal, neonatal, or early childhood outcomes; and were published as peer-reviewed reports in English.

Results
The search yielded 1101 unique references with 22 studies meeting eligibility criteria and representing 205 pregnancies and 171 infants.
The most common symptom of inhalant use reported in pregnant people was altered mentation, followed by renal tubular acidosis (RTA) reported with toluene use. Most common fetal outcomes included fetal growth restriction and preterm delivery (<37 weeks), while neonatal outcomes were withdrawal symptoms, such as jitteriness, trouble feeding, and dystonia. Child outcomes included developmental delays, including cognitive and speech impairments, and postnatal growth restriction, including microcephaly.

Conclusion
Perinatal, fetal, and child outcomes associated with inhalant use among pregnant individuals are largely based on case reports and series. Prospective studies are needed to better characterize these outcomes, reduce stigma, increase equitable access to treatment, and identify potential interventions to reduce use and potential harm.
Leveraging Implementation Factors and Policy to Improve the Effectiveness of Naloxone
Authors: Jordan Ashly E. , Brewster Mary , Mund Pamela , Hennessy Grace , Cunningham Chinazo O. 
Published: November 2024

Abstract
More than 50 years of high-quality data demonstrate that naloxone is an efficacious and cost-effective overdose reversal agent. Intranasal naloxone is now available in the United States as an over-the-counter and generic medication for the first time since the start of the overdose crisis more than 20 years ago. As the overdose crisis continues to contribute to substantial loss of life, there is an historic opportunity for jurisdictions to expand equitable and sustained access to intranasal naloxone. Further, through simultaneously enacting and expanding effective Naloxone Access and Good Samaritan laws, and equitably implementing these laws, there is the potential to maximize the population-level effectiveness of naloxone to sustainably reduce overdose mortality.
Omics studies in Behçet's disease
Authors: Ozguler Yesim , Nowatzky Johannes 
Published: November 2024

Purpose of review
In this review, we aimed to highlight recent findings from “-omics” studies in Behçet's disease.

Recent findings
Recent genomic studies in Behçet's disease identified possible risk loci associated with Behçet's disease related uveitis, neurologic involvement and gastrointestinal involvement. Additionally, sex-specific genetic effects were determined in Behçet's disease. Transcriptomic analyses of immune cells in Behçet's disease revealed that key inflammatory pathways such as NF-κB and MAPK have roles in Behçet's disease pathogenesis. Proteomic studies have highlighted the role of immune cell derived extracellular vesicles and identified potential biomarkers for vascular involvement and examined HLA I-bound immunopeptidomes. Metabolomics studies are still limited, but recent research has pointed to alterations in fatty acid metabolism and lipid profiles in Behçet's disease patient.

Summary
Omics studies have gained importance in the field of Behçet's disease through the generation of large data sets and efforts to extend their application are intensifying. These studies can provide opportunities for understanding Behçet's disease pathogenesis when they lead to testable hypotheses. Current challenges include the choice of appropriately homogeneous patient and control groups, effective data management and sharing, high cost and a rapidly increasing gap between the wealth of observational data generated and the relative paucity of controlled experimental efforts that could lead to mechanistic understanding.
Analysis of Serial Foot Radiographs to Determine Foot Height Multipliers
Authors: Nedder Victoria J. , Shah Ansh P. , Chen Kallie J. , Herzenberg John E. , Liu Raymond W. 
Published: November 2024

Background:
The multiplier method is an arithmetic calculation that estimates the amount of growth remaining until skeletal maturity. When predicting lower limb length discrepancy, differences in foot height are added to femur and tibia discrepancies. Foot height multipliers have not been calculated using radiographic measurements, so it is unclear whether foot height develops at the same pace as the femur and tibia. This study used serial images to calculate foot height multipliers and compared them to published lower limb and foot length multipliers.

Methods:
The Bolton Brush radiograph collection was used to measure foot height on the lateral foot view. Multipliers were calculated for ages with at least 10 serial study visits. 212 patients (2195 radiographs) were included in the study (102 female, 110 male patients). Foot height multipliers were calculated for ages 0 to 17 years (females) and 0 to 18 years (males).

Results:
Multipliers decreased with age, but qualitatively plateau at age 13 (females) and age 15 (males). Lower extremity multipliers have a more dramatic growth curve, indicating comparatively greater lower extremity growth after birth. However, when comparing the limb length discrepancy calculation using the lower extremity multiplier versus the foot height multiplier for the foot portion, the difference was negligible.

Conclusions:
This paper provides a database of foot height multipliers. Foot height seems to grow on a different trajectory than other lower limb components, confirming that one should consider separate multiplier values. The difference created by the foot height multiplier versus the lower extremity multiplier appears to be modest. Separate use of the foot height multiplier may only be necessary for young children with large foot height discrepancies, but further study to confirm the lack of impact of the foot height multiplier on limb length discrepancy calculations is needed. Our data were derived from normal children, so it is unknown if the presence of a talo-calcaneal coalition would affect foot height on the involved side.

Level of Evidence:
Level III—retrospective comparative study.
An Alternative Approach for Evaluating Induced and Contact Currents for Compliance with Their Exposure Limits (100 kHz to 110 MHz) in IEEE Std C95.1-2019
Authors: Tell Richard A. , Kavet Robert 
Published: November 2024

Abstract
The Institute of Electrical and Electronics Engineers establishes exposure reference levels (ERLs) for electric fields (E-fields) (0–300 GHz) and both induced (IIND
) and contact currents (ISC
) (<110 MHz) in its standard, IEEE Std C95.1™-2019 (IEEE C95.1). The “classical” scenarios addressed in IEEE C95.1 include a free-standing, grounded “reference” person (IIND
) or an ungrounded reference person in manual contact with an adjacent grounded conductor (ISC
), each exposed to a vertically oriented E-field driving the currents. The ERLs for current from 100 kHz to 110 MHz were established to limit heating in the finger (from touch), ankle (IIND
), and wrist (ISC
from grasp contact), specifying the 6-min average specific absorption rate (SAR, W kg−1) as the dosimetric reference limit (DRL); whole-body E-field ERLs are 30-min averages. The DRLs were established assuming a default “effective” local cross-section (9.5 cm2) and consistent with a composite tissue conductivity of ~0.5 S m−1. A previous publication described the misalignment of the ERLs for E-fields with the ERLs for IIND
(which extends to ISC
) and also proposed a ramped E-field ERL from 100 kHz to 30 MHz. For the frequency range 100 kHz to 110 MHz, this paper proposes temperature increase (ΔT) in ankle and wrist as the preferred effect metric associated with IIND
and ISC
; applying the E-field ERLs as surrogates for limits to these currents; and adopting the proposed ramp. The analysis of ΔT is based on the tissue mix in realistic anatomic depictions of ankle and wrist cross-sections; relevant tissue properties posted online; published tissue perfusion data; and anthropometric data on a large sample of male and female adults in the US military, allowing an estimate of effects over a range of body size. To evaluate ΔT versus frequency and time, the Penne bioheat equation was adapted with convective cooling from arterial blood as the lone cooling mechanism. The analysis revealed that IIND
s and ISC
s induced by ERL-level E-fields produce SARs in excess of the local DRLs (in some cases far exceed). Calculations of time to ΔT of 5 °C, reflective of a potentially adverse (painful) response, resulted in worst-case times for effects in the ankle on the order of minutes but on the order of 10s of s in wrist. Thus, compliance with the E-field ERL, as assessed as a 30-min whole-body average is incompatible with the time course of potentially adverse effects in ankle and wrist from IIND
and ISC
, respectively. Further analysis of the relevant exposure/dose scenarios and consensus of stakeholders with a multi-disciplinary perspective will enable the development of a revised standard, practical from a compliance perspective and protective of all persons.
Cataract surgery combined with glaucoma surgery
Authors: Torbey Julien , Mansouri Kaweh 
Published: November 2024

Purpose of review
This review evaluates the surgical management of glaucoma in patients undergoing cataract surgery. Combining both procedures present challenges in balancing intraocular pressure (IOP) control, minimizing postoperative complications, and achieving optimal refractive outcomes.

Recent findings
Recent studies highlight the effectiveness of combined glaucoma and cataract surgeries, with traditional filtering surgeries and MIGS showing significant IOP reduction. The abundance of long-term studies shows that MIGS can offer an effective and safer alternative when carefully tailored to meet the specific needs of each patient.

Summary
Combining glaucoma and cataract surgery is a promising approach for patients with coexisting conditions. While traditional surgeries offer robust IOP reduction, MIGS procedures offer better safety profiles with fewer complications and more predictable refractive results. Surgeons must carefully consider the timing and choice of procedures, with further research required to develop standardized treatment algorithms.
Interpersonal Relationship and Suicide Attempt
Authors: Zhou Qin , Li Ning , Li Chang An , Zhang Jie 
Published: November 2024

Abstract
This study investigates the role of family and social relationships in cases of attempted suicide in China. Studies, mostly analyzing data from developed countries, have indicated that interpersonal relationships are important predictors of suicidal behaviors. This study's data were derived from a case-control study in China. Family relationships included relationships with spouses, parents, and parents-in-law. Poor family and social relationships were significantly associated with increased risk of attempted suicide in women and men. Depression and social support significantly mediated the association between interpersonal relationship and attempted suicide. Poor relationship with spouse was significantly associated with an elevated risk of attempted suicide. Relationship with parents-in-law was also significantly associated with attempted suicide in women, whereas family relationships played a more important role than social relationships in suicidal behaviors, especially in men. The findings imply that suicide prevention in China could be conducted from the perspective of improving family relationships, especially husband/wife and parents/daughters-in-law relationships.
Reappraisal of Oncocytic Adenocarcinoma
Authors: Vial Lucas , Descotes Françoise , Lopez Jonathan , Alsugair Ziyad , Céruse Philippe , Philouze Pierre , Fieux Maxime , Wassef Michel , Baglin Anne-Catherine , Onea Mihaela , Castain Claire , Delvenne Philippe , Fromont-Hankard Gaelle , Gilles Hugot , Monnien Franck , Mauvais Olivier , Lépine Charles , Le Gall Francois , Rousselet Marie-Christine , Sudaka Anne , Uro-Coste Emmanuelle , Casiraghi Odile , Costes-Martineau Valérie , Benzerdjeb Nazim ,   on behalf of the REFCOR Network
Published: November 2024

Oncocytic adenocarcinoma (OC) of the salivary glands is a rare and controversial entity. It was recently reclassified as “salivary carcinoma NOS and emerging entities” in the 2022 WHO classification of head and neck tumors. The lack of specific molecular alterations and its potential affiliation with other salivary gland carcinomas, such as the oncocytic mucoepidermoid carcinomas (OMEC) or the oncocytic subtype of salivary duct carcinomas (OSDC) justified this reclassification. It is becoming essential to clarify the complex spectrum of potential diagnoses surrounding oncocytic tumors. The objective of this study was to explore the histologic features, as well as the immunohistochemical and molecular profiles, of cases previously diagnosed as OC or OMEC of the salivary glands. This study involved 28 cases of carcinomas with a predominantly oncocytic component. The sex distribution was equal. The median age was 59 years (range 10 to 89). Most of these cases originated from the parotid gland (25/28). The mean tumor size was 2.4 cm (range 0.5 to 6.5). Primary immuno-morphological and mutation/gene fusion profiles reclassified mainly (64.3%, 18/28). Most of them were reclassified in descending order as OSDC (8/18), OMEC (5/18), and OC (2/18). But 3 cases remained unclassified (3/18). The transcriptomic analysis found a proximity of their transcriptomic profile with the OMEC group and a distance from the OSDCs. These findings imply that OC is not distinct but represents oncocytic variants of other salivary carcinomas. It underscores the importance of thorough morphologic, immunohistochemical, and molecular examinations to accurately diagnose carcinomas with predominant oncocytic components in the salivary glands.
Caregiver Accompaniment in Pediatric Critical Care Transport
Authors: Yeung Matthew , Spence Tanya , Nikitovic Dejana , Gilad Eli 
Published: November 2024

Context
Family-centered care is a critical component of critical care interfacility and medical retrieval transport (MRT) services. These services provide a critical bridge for a physiologically and psychologically unique population often best served in specialized, tertiary centers. Caregivers often wish to accompany patients during MRT. However, there is currently little research on the impact of caregiver accompaniment on MRT.

Objective
The aim of the study is to determine: 1) What are caregiver attitudes to accompanied and unaccompanied MRT? 2) What are healthcare provider attitudes to caregiver presence? 3) What are patient attitudes to caregiver presence? and 4) Are there differences in patient outcome depending on caregiver presence?

Data Sources
Data sources are MEDLINE, Embase, and CINAHL.

Study Selection
Studies with a focus on patient, caregiver, or family-oriented care practices in MRT. Reviewed articles were not restricted unless they discussed neonatal transport, palliative transport, were non-English, or were conference proceedings.

Data extraction
We screened 1373 articles, with 45 full-text articles reviewed. After removal of duplicates and abstract-only results, 25 articles remained. Three additional articles were found in references of reviewed articles.

Results
Articles generally supported caregiver presence on MRT, with caregivers and providers in agreement. However, for many services, space was a limiting factor controlling when caregivers could travel.

Limitations
There is a paucity of literature on this topic, and studies were entirely from English-speaking countries.

Conclusions
Caregivers and healthcare providers largely prefer caregiver accompaniment on MRT services. There is little data on patient perspectives and transport-related adverse events affecting patient outcomes.
Evaluating the Efficacy of Deep Learning Reconstruction in Reducing Radiation Dose for Computer-Aided Volumetry for Liver Tumor: A Phantom Study
Authors: Nomura Masahiko , Ohno Yoshiharu , Ito Yuya , Kimata Hirona , Fujii Kenji , Akino Naruomi , Nagata Hiroyuki , Ueda Takahiro , Yoshikawa Takeshi , Takenaka Daisuke , Ozawa Yoshiyuki 
Published: November 2024

Objective
The purpose of this study was to compare radiation dose reduction capability for accurate liver tumor measurements of a computer-aided volumetry (CADv) software for filtered back projection (FBP), hybrid-type iterative reconstruction (IR), mode-based iterative reconstruction (MBIR), and deep learning reconstruction (DLR) at a phantom study.

Methods
A commercially available anthropomorphic abdominal phantom was scanned five times with a 320-detector row CT at 600 mA, 400 mA, 200 mA, and 100 mA and reconstructed by four methods. Signal-to-noise ratios (SNRs) of all lesions within the arterial and portal-venous phase inserts were calculated, and SNR of the lesion phantom was compared with that of all reconstruction methods by means of Tukey's honestly significant difference (HSD) test. Then, tumor volume (V) of each nodule was automatically measured using commercially available CADv software. To compare dose reduction capability for each reconstruction method at both phases, mean differences between measured V and standard references were compared by Tukey's honestly significant difference test among the four different reconstruction methods on CT obtained at each of the four tube currents.

Results
With each of the tube currents, SNRs for MBIR and DLR were significantly higher than those for FBP and hybrid-type IR (p < 0.05). At the arterial phase, the mean difference in V for the CT protocol obtained at 600 or 100 mA and reconstructed with DLR was significantly smaller than that for others (p < 0.05). At the portal-venous phase, the mean differences in V for the CT protocol obtained at 100 mA and reconstructed with hybrid-type IR, MBIR, and DLR were significantly smaller than that for FBP (p < 0.05).

Conclusions
Findings of our phantom study show that reconstruction method had influence on CADv merits for abdominal CT with not only standard but also reduced dose examinations and that DLR can potentially yield better image quality and CADv measurements than FBP, hybrid-type IR, or MBIR in this setting.
Potential of facial biomarkers for Alzheimer’s disease and Obstructive sleep apnea in Down syndrome and general population
Authors: Echeverry-Quiceno L.M , Llambrich S. , Heredia-Lidón Á. , Giménez S. , Rozalem-Aranha M. , Inampudi P. , Heuzé Y. , Sevillano X. , Fortea J. , Martínez-Abadías N. ,   Alzheimer’s Disease Neuroimaging Initiative
Published: November 2024

AbstractBackgroundDown syndrome (DS) is caused by trisomy 21, leading to increased risks of Alzheimer’s disease (AD) and Obstructive sleep apnea (OSA). Traditional diagnostic methods for AD and OSA, like cerebrospinal fluid analysis and polysomnography, are invasive and challenging for people with DS. Facial morphology has emerged as a non-invasive biomarker for these conditions. Therefore, we conducted a comprehensive 3D analysis of facial shape variation in DS and euploid control (EU) populations, assessing the effect of critical factors such as age, sex, and facial size, to investigate its association with AD and OSA.MethodsFacial shape differences among groups were analyzed from the coordinates of 21 landmarks automatically registered on 3D facial models generated from head magnetic resonance images in a cross-sectional sample of 131 individuals with DS and 216 EU controls from 18 to 90 years old, including subjects diagnosed with AD and OSA. We used Procrustes ANOVA and MANOVA tests to quantify the amount of facial shape variation attributable to sex, age, and facial size, and quantified facial shape differences among diagnostic groups using geometric morphometrics.ResultsBesides facial shape differences between DS and EU individuals, our results detected significant interactions between diagnosis and sex, and between diagnosis and age, indicating sex-dependent differences and an altered pattern of facial shape change over adulthood in DS, with females presenting more severe alterations. Multivariate regression analyses showed that facial shape significantly correlated with the concentration ratio between amyloid beta peptide 1- 42 and amyloid beta peptide 1-40 (Aβ1-42/Aβ1-40) in cerebrospinal fluid, a common biomarker for AD diagnosis. In the DS population, facial shape differences between individuals with and without AD diagnosis did not achieve statistical significance after adjusting for age and facial size, but significant shape differences were detected in the EU population. Regarding OSA, facial shape significantly correlated with the apnea-hypopnea index, and individuals with DS and severe OSA presented a significantly different facial morphology in comparison to individuals with DS and no signs of OSA, suggesting that facial morphology could be associated with sleep respiratory disturbances.ConclusionsOverall, our study underscores the potential of facial morphology as a diagnostic biomarker for the early detection and clinical management of AD and OSA.