bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTERİOR MAKSİLLER BÖLGEDEKİ BUKKAL KONKAVİTELERİN ANALİZİ: RETROSPEKTİF KONİK IŞINLI BİLGİSAYARLI TOMOGRAFİ ÇALIŞMASI
Authors: CAN Bilge , ÖNCÜ Elif 
Published: March 2019

Amaç: İmplant operasyonlarında komplikasyon riski ve ogmentasyon
gerekliliği oranını azaltmak için alveoler kemiğin topografisinin, komşu
anatomik yapıların ayrıntılı olarak değerlendirilmesi gerekmektedir. Bu çalışmada,
anterior maksilla bölgesindeki bukkal kret konkavitesinin yeri ve derinliği konik
ışınlı bilgisayarlı tomografi (KIBT) kullanılarak incelenmiştir.

Gereç ve Yöntemler: Sağ ve sol maksilla anterior bölgede kısmi ya da tam dişli
hastaların KIBT görüntüleri taranmıştır. Anterior dişlerin kesitsel görüntülerinde
milimetrik ölçümler yapılmıştır. Bukkal konkavite yeri ve konkavite derinliği üç
boyutlu olarak ölçülmüştür.

Bulgular: Bu çalışmada bukkal konkavite görülme oranı sırasıyla sağ
maksillada santralde %23,3, lateralde %44,3 ve kaninde %26,4; sol maksillada
santralde %20,3, lateralde %47,1 ve kanin bölgesinde %18,3’tür. Sağ ve sol
lateral dişler en fazla bukkal konkavite oranına sahip dişlerdir. Bukkal
konkavitenin yeri alveoler kret tepesine en uzak dişler 7,63 mm ile sağ santral
ve 8,06 mm ile sol santraldir. Bukkal konkavite derinlikleri en sığ dişler
ortalama 1,41 mm ile sağ kanin ve ortalama 1,54 mm ile sol kanin olarak
bulunmuştur. Bukkal konkavitenin yerinin ve derinliğinin yaşa, sağ-sol
simetrisine ve cinsiyetlere göre yapılan karşılaştırmalı değerlendirme
sonucunda istatiksel olarak anlamlı fark bulunamamıştır.

Sonuçlar: Bu çalışmanın limitasyonları dahilinde, implant
operasyonlarında lateral dişler cerrahi komplikasyon oranı ve greftleme
gerekliliği açısından daha yüksek riske sahipken kanin dişler daha güvenli
kabul edilebilir.

Anahtar Kelimeler: Bukkal konkavite, dehissens, immediat implant, konik ışınlı
bilgisayarlı tomografi
The Whole Genome Sequence and mRNA Transcriptome of the Tropical Cyclopoid Copepod Apocyclops royi
Authors: Jørgensen Tue Sparholt , Nielsen Bolette Lykke Holm , Petersen Bent , Browne Patrick Denis , Hansen Benni Winding , Hansen Lars Hestbjerg 
Published: March 2019

Abstract
Copepoda is one of the most ecologically important animal groups on Earth, yet very few genetic resources are available for this Subclass. Here, we present the first whole genome sequence (WGS, acc. UYDY01) and the first mRNA transcriptome assembly (TSA, Acc. GHAJ01) for the tropical cyclopoid copepod species Apocyclops royi. Until now, only the 18S small subunit of ribosomal RNA gene and the COI gene has been available from A. royi, and WGS resources was only available from one other cyclopoid copepod species. Overall, the provided resources are the 8th copepod species to have WGS resources available and the 19th copepod species with TSA information available. We analyze the length and GC content of the provided WGS scaffolds as well as the coverage and gene content of both the WGS and the TSA assembly. Finally, we place the resources within the copepod order Cyclopoida as a member of the Apocyclops genus. We estimate the total genome size of A. royi to 450 Mb, with 181 Mb assembled nonrepetitive sequence, 76 Mb assembled repeats and 193 Mb unassembled sequence. The TSA assembly consists of 29,737 genes and an additional 45,756 isoforms. In the WGS and TSA assemblies, &gt;80% and &gt;95% of core genes can be found, though many in fragmented versions. The provided resources will allow researchers to conduct physiological experiments on A. royi, and also increase the possibilities for copepod gene set analysis, as it adds substantially to the copepod datasets available.
Dispareunia masculina
Authors: Villarreal Valerio Julián Anibal 
Published: March 2019

La dispareunia masculina es un síntoma poco conocido, pero con gran impacto en la calidad de vida de los hombres que lo padecen. Existe escasa investigación sobre este tema en comparación con su contraparte femenina. En su etiología se presenta una amplia variedad de patologías con predominancia de componentes orgánicos, por lo que es importante conocer y entender las causas para el oportuno tratamiento. Para el diagnóstico de la dispareunia, una adecuada historia, anamnesis, y examen físico, son fundamentales para orientar a su posterior evolución y manejo del trastorno mediante las nuevas opciones de tratamiento que se cuenta en la actualidad, donde es de utilidad el abordaje individualizado y teniendo en cuenta otros factores emocionales y socio-culturales. En esta revisión, se expone un enfoque sobre la frecuencia, diagnóstico, evaluación y tratamiento de este síntoma bastante complejo, que en algunas oportunidades puede tener repercusión en las relaciones interpersonales.
Incidencia de tuberculosis en pacientes con psoriasis que reciben terapias anti- TNF- alfa en Latinoamérica: revisión sistemática y metaanálisis
Authors: Contreras Maza Roniel Gonzalo 
Published: March 2019

La incidencia global de tuberculosis en pacientes con psoriasis recibiendo anti-factor de necrosis tumoral (TNF)- α en Latinoamérica es desconocida, a pesar del uso cada vez mayor de dichas terapias, y de las elevadas tasas de incidencia de tuberculosis en la región, por lo que se efectuó una revisión sistemática y metaanálisis sobre el tema. Para dicha revisión, se incluyeron estudios que reporten la incidencia de tuberculosis activa en pacientes con psoriasis recibiendo anti- TNF- α en Latinoamérica, usando cuatro bases de datos electrónicas: Pubmed, Scielo, LILACS y Medigraphic, para luego efectuar un metaanálisis sobre dichas incidencias y obtener proporciones conjuntas. Finalmente, se seleccionaron 9 estudios los cuales fueron realizados en Argentina, Brasil, Chile, Colombia y México, con un seguimiento total de 510,9 pacientes- año, y obteniéndose un total de 3 casos de tuberculosis activa, lo cual constituye una incidencia estimada de 636 casos de tuberculosis por cada 100 mil pacientes/año (intervalo de confianza al 95% [IC 95%]: 145-1764 por 100 mil pacientes/año), tras usar el modelo de efectos fijos, siendo dicha incidencia elevada en relación a las tasas de incidencia poblacionales en la región, y comparable a otras poblaciones que recibieron terapias anti- TNF- α por psoriasis en otras
Factores de riesgo asociados a mortalidad por paro cardiaco intraoperatorio en el Hospital Nacional Guillermo Almenara Irigoyen, 2011-2015
Authors: Rosas Marroquín Victor Hugo , Menacho Terry Jorge , Troncos Merino Tania , Cabana Cruz Luis , Belloso Torres Brenner , Rosas Chávez Fiorella 
Published: March 2019

Introducción. La incidencia y mortalidad de paro cardiaco intraoperatorio (PCI) son indicadores de la calidad de atención y eficiencia en centros quirúrgicos. Objetivo. Determinar los factores de riesgo asociados a mortalidad por PCI en el Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú, durante los años 2011 a 2015. Métodos. Se realizó un estudio observacional, descriptivo y retrospectivo de PCI ocurridos en el periodo de estudio, donde se determinó el riesgo relativo. Resultados. Entre los años 2011 a 2015 ocurrieron 88 PCI de un total de 74 096 cirugías realizadas; la incidencia de PCI fue de 11,87 x 10 000 cirugías. De los 88 PCI, 39 pacientes fallecieron (44,3%); la mortalidad intraoperatoria fue 5,26 x 10 000 cirugías. Los factores de riesgo asociados a mortalidad por PCI fueron: RCP mayor de 20 minutos (RR: 3,9), clasificación ASA (RR: 3,4), cirugía cardiovascular (RR: 2,9), causas quirúrgicas (RR:2,9), etapa de mantenimiento anestésico (RR:2,0). Conclusiones. En el periodo de estudio la incidencia de PCI fue de 11,87 x 10 000 cirugías; los factores de riesgo asociados a mortalidad por PCI fueron la RCP mayor de 20 minutos, alto riesgo ASA, cirugía por enfermedad cardiovascular, eventos adversos relacionados con cirugías y mantenimiento anestésico.
Caminando junto a la tuberculosis
Authors: Ticona Eduardo 
Published: March 2019

En países con elevada endemia tuberculosa, las personas están muy cerca a esta enfermedad a lo largo de toda su vida. Sea porque algún familiar o amigo desarrolla la enfermedad o porque en el devenir de la vida experimenta la infección o la enfermedad. En el caso del médico o profesional de la salud, seguramente su cercanía será mayor, y preferentemente si se dedica a actividades de prevención y control en tuberculosis. En este artículo se exponen las experiencias cercanas con la tuberculosis desde nuestra infancia, como estudiante de medicina, médico, investigador, salubrista y docente universitario, donde el profesional pasa situaciones afectivas personales, temas de limitaciones de conocimiento, limitaciones en el diagnóstico, hasta ejecución de investigaciones sobre problemas locales y generando respuestas en la prevención y control. Seguramente es una experiencia común en profesionales de salud que en el día a día enfrentan esta endemia, de la cual cada vez conocemos más, pero se nos hace muy difícil su control.
Microfiltración apical entre tres cementos utilizados en obturación retrógrada
Authors: Legarda Canales Vinicio Vladimir , Martini Garcia Isadora , Mena Silva Paola Andrea , Hidalgo Moya Viviana Marcela , Guillén Guillén Raquel Esmeralda 
Published: March 2019

Objetivo: Determinar la microfiltración apical de tres cementos utilizados en obturación retrógrada. Métodos: 45 piezas unirradiculares estandarizadas a 16 mm de longitud se instrumentaron con sistema ProTaper® manual e irrigaron con NaClO al 5,25%. Las muestras fueron obturadas con cono principal ProTaper® F3 y accesorios Denstply® #A y #B; se realizó la recesión apical de 3 mm, posteriormente se desobturó 3 mm con ultrasonido (Satelec Acteon) con punta s12/70D; se dividió la muestra en tres grupos para realizar obturación retrógrada con diferentes cementos de obturación cada uno. Las muestras se incubaron a 37 °C por 3 días; se cubrieron con barniz de uñas excepto 2 mm apicales para ser sumergidas en azul de metileno al 1% por 48 horas, se lavaron y realizaron un corte longitudinal con disco de diamante #2 para su análisis en el estereomicroscopio (EduBlue ED 1402S), con la ayuda de un micrómetro (Stainless Hardened) se obtuvieron diferentes valores de cada grupo, mismos que fueron analizados por medio de la comparación de medias y pruebas paramétricas. Resultados: La valoración media de la microfiltración que produce la obturación retrógrada indica que: el MTA® presentó un valor de 87,33 ± 9,61 µm (14,57%), seguido del Biodentine® con 136 ± 12,42 µm (22,69%), con respecto al IRM® con mayor cantidad de microfiltración con un valor de 376 ± 12,98 µm (62,74%). Conclusiones: Al comparar las medias y porcentajes de la microfiltración apical que presentan los cementos IRM®, Biodentine® y MTA®, se evidenció que el MTA® presentó el menor valor de microfiltración.
Quality Metrics for Antimicrobial Stewardship Programs
Authors: Science Michelle , Timberlake Kathryn , Morris Andrew , Read Stanley , Le Saux Nicole ,   on behalf of the Groupe Antibiothérapie en Pédiatrie Canada Alliance for Stewardship of Antimicrobials in Pediatrics (GAP Can ASAP)
Published: March 2019

BACKGROUND:
Antimicrobial stewardship programs (ASPs) are targeted to optimize antimicrobial use. However, pediatric metrics used to measure outcomes of ASPs are not well established. Our aim for this project was to identify, refine, and develop consensus on standard metrics for pediatric ASPs.

METHODS:
By using a modified Delphi process, 2 surveys were sent to experts and stakeholders to establish consensus on the utility of metrics. These were subdivided into 4 ASP domains: (1) antimicrobial consumption, (2) microbiologic outcomes, (3) clinical outcomes, and (4) process measures. Respondents were asked to rank the scientific merit, impact, feasibility, and accountability of each metric. Metrics with ≥75% agreement for scientific merit were included and metrics with ≤25% agreement were discarded. Consensus was finalized with a face-to-face meeting and final survey.

RESULTS:
Thirty-eight participants from 15 pediatric hospitals across Canada completed all 3 rounds of the Delphi survey. In the domain of antimicrobial consumption, the 2 selected metrics were (1) days of therapy per 1000 patient-days and (2) total antimicrobial days. The clinical and process outcomes chosen were (1) 30-day readmission rate and (2) adherence to ASP recommendations, respectively. A microbiologic outcome was felt to be important and feasible, but consensus could not be obtained on a measure. Several barriers to implementation of the metrics were identified, including information technology limitations at various centers.

CONCLUSIONS:
We obtained consensus on 4 metrics to evaluate pediatric antimicrobial stewardship activities in Canada. Adoption of these metrics by pediatric ASPs will facilitate measurement of outcomes nationally and internationally.
A phenomenology of subjectively relevant experiences induced by ayahuasca in Upper Amazon vegetalismo tourism
Authors: Wolff Tom John , Ruffell Simon , Netzband Nigel , Passie Torsten 
Published: March 2019

AimsThis heuristic study reports observations on the phenomenology of ayahuasca experiences of nine foreign tourist participants of an ayahuasca retreat in Peru.MethodsNarrative interviews, reflecting individual experiences after ayahuasca “night ceremony,” have been analyzed by qualitative content analysis using a data-driven strategy in order to extract themes and categories inherent in the interviews. Previously, a demographic questionnaire was given. The dose–response connection was uncontrolled, which is typical for this naturalistic setting.ResultsThe typical structure of spontaneously reported experiences includes: personal preparation, physical symptoms, visual phenomena, cognitive and emotional phenomena, reactions of the individual within the psychedelic “world” as well as within ordinary reality, and appraisal to the process. Emotional reactions were subsumed under pleasant (psychotherapeutic “target emotions” and hedonistic emotions) and unpleasant emotions. For a majority, the presence of psychotherapeutic target emotions seemed to involve the presence of unpleasant emotions in the same session – possibly as transitional emotional states.ConclusionsThis suggests that psychodynamic processes, for example, possible activation of emotional conflicts – can take place spontaneously, during ayahuasca intake in this particular setting. Some participants attributed symbolic meaning to the visionary content, which was more likely to take place in psychotherapeutically motivated clients. The specific setting influence as well as corresponding expectations of the participants in native wisdom could have considerable influence on experiences and interpretations, such as communication with entities as well as receiving personal teachings.
Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma
Authors: Thierauf Julia , Ramamurthy Nisha , Jo Vickie Y. , Robinson Hayley , Frazier Ryan P. , Gonzalez Jonathan , Pacula Maciej , Dominguez Meneses Enrique , Nose Vania , Nardi Valentina , Dias-Santagata Dora , Le Long P. , Lin Derrick T. , Faquin William C. , Wirth Lori J. , Hess Jochen , Iafrate A. John , Lennerz Jochen K. 
Published: March 2019

Abstract

Background
Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy without effective systemic therapies. Delineation of molecular profiles in ACC has led to an increased number of biomarker-stratified clinical trials; however, the clinical utility and U.S.-centric financial sustainability of integrated next-generation sequencing (NGS) in routine practice has, to our knowledge, not been assessed.

Materials and Methods
In our practice, NGS genotyping was implemented at the discretion of the primary clinician. We combined NGS-based mutation and fusion detection, with MYB break-apart fluorescent in situ hybridization (FISH) and MYB immunohistochemistry. Utility was defined as the fraction of patients with tumors harboring alterations that are potentially amenable to targeted therapies. Financial sustainability was assessed using the fraction of global reimbursement.

Results
Among 181 consecutive ACC cases (2011–2018), prospective genotyping was performed in 11% (n = 20/181; n = 8 nonresectable). Testing identified 5/20 (25%) NOTCH1 aberrations, 6/20 (30%) MYB-NFIB fusions (all confirmed by FISH), and 2/20 (10%) MYBL1-NFIB fusions. Overall, these three alterations (MYB/MYBL1/NOTCH1) made up 65% of patients, and this subset had a more aggressive course with significantly shorter progression-free survival. In 75% (n = 6/8) of nonresectable patients, we detected potentially actionable alterations. Financial analysis of the global charges, including NGS codes, indicated 63% reimbursement, which is in line with national (U.S.-based) and international levels of reimbursement.

Conclusion
Prospective routine clinical genotyping in ACC can identify clinically relevant subsets of patients and is approaching financial sustainability. Demonstrating clinical utility and financial sustainability in an orphan disease (ACC) requires a multiyear and multidimensional program.

Implications for Practice
Delineation of molecular profiles in adenoid cystic carcinoma (ACC) has been accomplished in the research setting; however, the ability to identify relevant patient subsets in clinical practice has not been assessed. This work presents an approach to perform integrated molecular genotyping of patients with ACC with nonresectable, recurrent, or systemic disease. It was determined that 75% of nonresectable patients harbor potentially actionable alterations and that 63% of charges are reimbursed. This report outlines that orphan diseases such as ACC require a multiyear, multidimensional program to demonstrate utility in clinical practice.
MECHANICAL CIRCULATORY SUPPORT IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Authors: Grechishkin A. A. , Mayngart S. V. , Nekrasov A. S. , Fedorchenko A. N. , Porhanov V. A. 
Published: March 2019

Despite the rapid evolution in the development of endovascular surgery, the mortality of patients undergoing percutaneous coronary interventions (PCI) with high risk of severe cardiac complications and critical conditions (cardiogenic shock, cardiac arrest) remains extremely high. The success of PCI directly depends on the ability of the Heart Team to prevent and timely eliminate severe cardiac disorders. Despite the rapid evolution in the development of endovascular surgery, the mortality of patients undergoing percutaneous coronary interventions (PCI) with high risk of severe cardiac complications and critical conditions (cardiogenic shock, cardiac arrest) remains extremely high. The success of PCI directly depends on the ability of the Heart Team to prevent and timely eliminate severe cardiac disorders. Pharmacological therapy is not able to completely resist the development of severe cardiac events during PCI. In such situations the usage of devices for percutaneous mechanical circulation support (PMCS) can make an invaluable help in the treatment of this group of patients. Despite the fact that the PMCS devices are used to stabilize patients with cardiogenic shock and to provide hemodynamic support for high-risk PCI for several decades, the results of their application remain ambiguous. The purpose of this article is to review all existing literature on modern PMCS devices, available data and research results, indications for their use, and operational considerations that can ensure the decision-making process in selecting optimal PMCS devices.
12-MONTHS RESULTS OF LEFT MAIN STENTING IN PATIENTS WITH HIGH SYNTAX SCORES
Authors: Stolyarov D. P. , Sakhnov E. V. , Melnikov A. V. , Pligovka I. N. , Komarova E. V. , Tovbis E. M. , Sakovich V. A. 
Published: March 2019

Aim. To compare the safety and efficacy of stenting of the left main coronary artery (LMCA) in patients with moderate to high risks estimated with the SYNTAX score.Methods.112 patients with multivessel coronary disease and LMCA disease (SYNTAX score ≥23) and severe comorbidities were included in the study. All patients were deemed ineligible for CABG by the Heart Team. Patients were assigned to two groups according to the Syntax scores: Group 1 – patients with the SYNTAX scores of 23–32 (n = 66), and Group 2 patients with the SYNTAX scores of >32 (n = 46).Results.107 patients completed the 12-months follow-up. 5 patients in Group 1 and 2 patients in Group 2 were lost to follow up. Myocardial infarction (MI) (8.06% versus 13.33%, p = 0.37757) and heart mortality (6.45% versus 6.67%, p = 0.9646) cumulative rates were similar within the 12-month follow-up. There were no strokes or noncardiac deaths in both groups. The 12-month confirmed rate of stent thrombosis in Groups 1 and 2 did not differ statistically (3.23% vs. 6.67%, p = 0.4051). The unadjusted model (effects of variables on survival) reported that age (OR 1.15 (95% CI 1.05– 1.26), p = 0.0032), pulmonary hypertension (OR 1.05 (95% CI 1.01–1.09), p = 0.0111) and mitral insufficiency (OR 2.65 (95% CI 1.13–6.21), p = 0.0252) affected the composite endpoint. The adjusted model determined that only age affected the prognosis (OR 1.17 (95% CI 1.05–1.29), p = 0.0038).Conclusion.The first results of our study showed that stenting of LMCA in patients with moderate to high SYNTAX scores is a possible option and comparable with the 12-month follow-up. Age is as an independent predictor of future adverse events. Further evaluation of this complex patient cohort is required.
A spatial individual-based contact model with age structure
Authors: Jasińska Dominika 
Published: March 2019

The Markov dynamics of an infinite continuum birth-and-death system of point particles with age is studied. Each particle is characterized by its location \(x\in \mathbb{R}^d\) and age \(a_x\geq 0\). The birth and death rates of a particle are age dependent. The states of the system are described in terms of probability measures on the corresponding configuration space. The exact solution of the evolution equation for the correlation functions of first and second orders is found.
On almost complex structures from classical linear connections
Authors: Kurek Jan , Mikulski Włodzimierz M. 
Published: March 2019

Let \(\mathcal{M} f_m\) be the category of \(m\)-dimensional manifolds and local diffeomorphisms and let \(T\) be the tangent functor on \(\mathcal{M} f_m\). Let \(\mathcal{V}\) be the category of real vector spaces and linear maps and let \(\mathcal{V}_m\) be the category of \(m\)-dimensional real vector spaces and linear isomorphisms. We characterize all regular covariant functors \(F:\mathcal{V}_m\to\mathcal{V}\) admitting \(\mathcal{M} f_m\)-natural operators \(\tilde J\) transforming classical linear connections \(\nabla\) on \(m\)-dimensional manifolds \(M\) into almost complex structures \(\tilde J(\nabla)\) on \(F(T)M=\bigcup_{x\in M}F(T_xM)\).
The natural operators of general affine connections into general affine connections
Authors: Kurek Jan , Mikulski Włodzimierz M. 
Published: March 2019

We reduce the problem of describing all \(\mathcal{M} f_m\)-natural operators transforming general affine connections on \(m\)-manifolds into general affine ones to the known description of all \(GL(\mathbf{R}^m)\)-invariant maps \(\mathbf{R}^{m*}\otimes \mathbf{R}^m\to \otimes^k\mathbf{R}^{m*}\otimes\otimes ^k\mathbf{R}^m\) for \(k=1,3\).
Determination of surface free energy components of organic liquids by the thin layer wicking method
Authors: Hołysz Lucyna , Szcześ Aleksandra 
Published: March 2019

<p><span lang="EN-US">Using the layer wicking method (TLW method) the electron-donor interactions of surface free energy of the organic liquids: benzene (C<sub>6</sub>H<sub>6</sub>), toluene C<sub>6</sub>H<sub>5</sub>CH<sub>3</sub>), and tetrahydrofuran ((CH<sub>2</sub>)<sub>4</sub>O) was determined. <span lang="EN-US">For this purpose the penetration rate measurements of these liquids in the porous layers of silica gel and alumina were performed. </span></span>The obtained values of the electron-donor parameter of surface free energy of the studied organic liquids were compared with the literature data obtained by the direct measurement of the interface tensions of water/organic liquids.</p>