bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients?
Authors: Lunze Fatima I. , Narciso Ryan , Gauvreau Kimberlee , Blume Elizabeth D. , Colan Steven D. , Singh Tajinder P 
Published: July 2019

AbstractLV E/E′ ratio obtained using Doppler echocardiography is considered a surrogate for LV filling pressure in adults but has performed poorly in children. We hypothesized that LV E/E′ ratio Z‐score, adjusted for age, will relate more strongly to LV filling pressures than LV E/E′ ratio in pediatric HT recipients. We analyzed 751 echocardiograms performed within 24 hours of a heart catheterization in 122 pediatric HT recipients (median age at HT 13 years, median 6 studies per patient). The primary end‐point was PCWP, assessed both as a continuous and a binary variable. Associations with LV E/E′ ratios and z‐scores were assessed using generalized estimating equations models. PCWP, LV E/E′ ratios (using E′ from LV free wall, septum, and their average), and LV E/E′ ratio Z‐scores, all declined over time after HT. LV E/E′ ratios and their Z‐scores were significantly associated with PCWP assessed as a continuous variable (P < 0.001 for all); however, the relationship was weak (R2 range, 0.083 to 0.121). LV E/E′ ratios and their Z‐scores were also significantly associated with PCWP as a binary variable (P < 0.001 for all) but with only modest ability to discriminate PCWP ≥15 mm Hg (c‐statistic range, 0.660 to 0.695). The association between LV E/E′ ratio and PCWP in pediatric HT recipients is modest. Using a LV E/E′ ratio Z‐score did not result in significantly improved association with PCWP. Current Doppler echocardiographic methods are unreliable for estimating LV filling pressures in pediatric HT recipients.
Quantitative Risk Assessment of Seafarers’ Nonfatal Injuries Due to Occupational Accidents Based on Bayesian Network Modeling
Authors: Zhang Guizhen , Thai Vinh V. , Law Adrian Wing‐Keung , Yuen Kum Fai , Loh Hui Shan , Zhou Qingji 
Published: July 2019

AbstractReducing the incidence of seafarers’ workplace injuries is of great importance to shipping and ship management companies. The objective of this study is to identify the important influencing factors and to build a quantitative model for the injury risk analysis aboard ships, so as to provide a decision support framework for effective injury prevention and management. Most of the previous research on seafarers’ occupational accidents either adopts a qualitative approach or applies simple descriptive statistics for analyses. In this study, the advanced method of a Bayesian network (BN) is used for the predictive modeling of seafarer injuries for its interpretative power as well as predictive capacity. The modeling is data driven and based on an extensive empirical survey to collect data on seafarers’ working practice and their injury records during the latest tour of duty, which could overcome the limitation of historical injury databases that mostly contain only data about the injured group instead of the entire population. Using the survey data, a BN model was developed consisting of nine major variables, including “PPE availability,” “Age,” and “Experience” of the seafarers, which were identified to be the most influential risk factors. The model was validated further with several tests through sensitivity analyses and logical axiom test. Finally, implementation of the result toward decision support for safety management in the global shipping industry was discussed.
eHealth tool for patients with abdominal aortic aneurysm: development and initial evaluation
Authors: Nilsson Olga , Hultgren Rebecka , Letterstål Anna 
Published: July 2019

RationaleAbdominal aortic aneurysm (AAA) is a prevalent condition among elderly men and may require surgical repair. Recent technical advances offer new opportunities to provide patients and next of kin with tailored and individualised information. eHealth tools have proven useful in other patient cohorts, but there are currently no validated educational eHealth tools for patients with AAA.AimOur aim was to develop and evaluate an eHealth tool for patients with abdominal aortic aneurysm using a participatory design process.MethodPatients, healthcare professionals and a technical team were involved in the development of the eHealth tool. The tool was assessed for content and usability through questionnaires, validated instruments and focus group interviews. Readability was assessed using Flesch Reading Ease Score (FRE) and Flesch–Kincaid Grade Level (FKGL). Interview data were analysed using thematic content analysis.ResultsFactual content and illustrations were accurate and in line with current information routine. Readability assessments produced a mean FRE score of 42.2 (±3,7) and mean FKGL of 10 (±1), implying that the eHealth tool may be difficult to comprehend for certain users. However, participants in the focus group interviews found the tool to be understandable, relevant and easy to use.ConclusionThe developed eHealth tool is acceptable, understandable and usable for the potential end‐users. Further evaluation of the usability of the tool and effect on outcome in clinical care is warranted. This is the first educational eHealth tool for patients with AAA and has potential to contribute to improved communication and quality of care for AAA patients.
A place of understanding: Patients' lived experiences of participating in a sexual rehabilitation programme after heart disease
Authors: Palm Pernille , Missel Malene , Zwisler Ann‐Dorthe , Svendsen Jesper Hastrup , Giraldi Annamaria , Berg Selina Kikkenborg 
Published: July 2019

AbstractAims and objectivesThe aim of this project was to explore the lived experience of participating in a nonpharmacological sexual rehabilitation programme.BackgroundIn the healthcare system, patients are important stakeholders, and their experience and knowledge are essential to include when evaluating rehabilitation programmes. Patient experiences with participating in sexual rehabilitation for cardiovascular patients have not yet been investigated.MethodsTen qualitative interviews were conducted with male patients from a randomised controlled trial investigating the effect of a 12‐week rehabilitation programme focusing on sexuality. The analysis was inspired by Paul Ricoeur's theory of interpretation. Analysis consisted of three levels: (i) naive reading, (ii) structural analysis and (iii) critical interpretation and discussion. The theoretical framework reflects aspects of behavioural theory of social cognitive theory developed by Albert Bandura and his concept of self‐efficacy.ResultsThe findings are presented as themes extracted from the structural analysis and interpreted in the critical interpretation and express the way in which cardiovascular patients experience participating in a sexual rehabilitation programme. Three themes were identified reflecting the intervention to be a special place of understanding, describing the intervention as a supporting atmosphere and finally expressing the intervention as empowering sexuality.ConclusionsParticipating in the sexual rehabilitation programme was experienced as efficient, valuable, motivating and safe, but dependent on a professional setting. The intervention developed participants' self‐efficacy with regard to their sexual performance and relationship.Relevance to clinical practiceThe findings highlight the importance of a professional setting including certain competencies such as humour and professional skills when handling the after‐care of cardiovascular patients with sexual problems.
The Intonation of the Left Periphery: A Matter of Pragmatics or Syntax?
Authors: Sequeros‐Valle Jose 
Published: July 2019

AbstractThis article investigates the intonation of the left periphery and its relationship with discourse and syntax. While some authors hypothesize that intonational patterns align with discourse functions (Bianchi & Frascarelli 2010, Frascarelli & Hinterhölzl 2007), others argue that intonational patterns are correlated with different types of constructions (Feldhausen 2016). In order to solve whether discourse or syntax predicts intonation in the left periphery, 12 participants completed a scripted production task. Two syntactic constructions, focus fronting and clitic‐doubled left dislocation, and two discourse functions, contrast and familiarity, were combined into three conditions: (i) contrastive–focus fronting, (ii) contrastive–clitic‐doubled left dislocation, and (iii) familiar–clitic‐doubled left dislocation. Results show that the overall intonational pattern of the left periphery aligns to construction type, with focus fronting presenting one nuclear configuration (L+H* L‐ no‐pause) and clitic‐doubled left dislocation presenting a different one (L+H* !H no‐pause). These findings are consistent with the construction‐based hypothesis and challenge the discourse‐based hypothesis.
Conformational regulation of AP1 and AP2 clathrin adaptor complexes
Authors: Beacham Gwendolyn M. , Partlow Edward A. , Hollopeter Gunther 
Published: July 2019

AbstractHeterotetrameric clathrin adaptor protein complexes (APs) orchestrate the formation of coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes enriched for phosphatidylinositol 4‐phosphate, such as the trans Golgi network, while AP2 associates with phosphatidylinositol 4,5‐bisphosphate of the plasma membrane. At their respective membranes, AP1 and AP2 bind the cytoplasmic tails of transmembrane protein cargo and clathrin triskelions, thereby coupling cargo recruitment to coat polymerization. Structural, biochemical and genetic studies have revealed that APs undergo conformational rearrangements and reversible phosphorylation to cycle between different activity states. While membrane, cargo and clathrin have been demonstrated to promote AP activation, growing evidence supports that membrane‐associated proteins such as Arf1 and FCHo also stimulate this transition. APs may be returned to the inactive state via a regulated process involving phosphorylation and a protein called NECAP. Finally, because antiviral mechanisms often rely on appropriate trafficking of membrane proteins, viruses have evolved novel strategies to evade host defenses by influencing the conformation of APs. This review will cover recent advances in our understanding of the molecular inputs that stimulate AP1 and AP2 to adopt structurally and functionally distinct configurations.
Evaluation of four techniques for injection of the proximal interphalangeal joint in horses
Authors: Mereu Matteo , Hawkes Claire , Cuddy Laura C. , Perez Olmos Juan F. , Pazzola Michele , McNally Turlough P. 
Published: July 2019

AbstractObjectiveTo describe a dorsoproximal midline (DPM) standing technique for proximal interphalangeal joint (PIPJ) injection and to compare it to established dorsolateral flexed (DLF), palmaroproximal (PP), and dorsolateral standing (DLS) techniques.Study designEx vivo study.Sample populationSixty cadaver equine thoracic limbs.MethodsLimbs were divided into four groups (n = 15 each group), DLF, DPM, PP, and DLS. For each technique, three operators injected radiopaque contrast and methylene blue into the PIPJ in five limbs. The number of attempts required was recorded. Successful injection was confirmed by radiographic presence of contrast media within the PIPJ. Iatrogenic cartilage damage was assessed by gross examination. Statistical analysis was performed by Wilcoxon signed‐rank test (P < .05).ResultsThe overall success rates were 86.6% to 93.3%. Although there was no difference in success rate, the frequency of needle repositioning was influenced by injection technique (P = .009). Dorsolateral standing had the highest mean ± SD value of attempts required to insert the needle in the joint space (2.62 ± 1.94). Injection technique influenced cartilage damage (P = .025), with the highest frequency recorded for DLS.ConclusionAll four techniques for injecting the PIPJ were highly successful; DLS was associated with the highest number of needle repositionings and the highest incidence of iatrogenic injury to cartilage.Clinical significanceDorsolateral flexed should be considered as an alternative to the DLS technique to reduce iatrogenic cartilage injury when injecting the PIPJ. Dorsoproximal midline and DLF techniques have success rates comparable to traditional techniques, with lower incidence of iatrogenic cartilage damage in cadaver limbs.
Prevalence of enteric non‐typhoidal Salmonella in humans in the Middle East and North Africa: A systematic review and meta‐analysis
Authors: Al‐Rifai Rami H. , Chaabna Karima , Denagamage Thomas , Alali Walid Q. 
Published: July 2019

AbstractTo enhance efforts related to controlling foodborne pathogens in the Middle East and North Africa (MENA), information on epidemiology of non‐typhoidal Salmonella enterica (hereafter termed “Salmonella”) is limited. We quantified the overall regional and country‐specific Salmonella prevalence in different human populations and identified the most common serotypes. Published literature of Salmonella prevalence was systematically reviewed and reported following the Preferred Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines. Pooled Salmonella prevalence measures were estimated using a random‐effects model. We identified 46 research reports that reported 84 Salmonella prevalence measures in 15 out of 24 countries in MENA. There were 252,831 tested humans with 6,356 Salmonella‐positive cases. The pooled Salmonella prevalence in MENA was estimated at 6.6% (95% confidence interval (CI): 5.4%–7.9%). The highest pooled Salmonella prevalence measures were in Morocco (17.9%, 95% CI: 5.7%–34.8%, 1997–2012), Tunisia (10.2%, 95% CI: 4.3%–18.0%, 1988–2009) and Sudan (9.2%, 95% CI: 6.5%–12.2%, 2006–2008), while the lowest were in Jordan (1.1%, 95% CI: 0.1%–3.0%, 1993–2010), Oman (1.2%, 95% CI: 1.2%–1.3%, 1998–2002) and Palestine (1.2%, 95% CI: 0.4%–2.1%, 1999–2011). In MENA, Salmonella pooled prevalence in gastrointestinal symptomatic, gastrointestinal asymptomatic and food handlers population groups was 13.0% (95% CI: 7.6%–19.6%), 11.4% (95% CI: 2.2%–25.7%) and 3.8% (95% CI: 1.0%–8.0%), respectively. Salmonella prevalence was 14.5% (95% CI: 8.7%–26.1%) in studies tested <100 subjects, whereas 4.6% (95% CI: 3.6%–5.8%) in studies tested ≥100 subjects. Salmonella Enteritidis (29.8%) and Typhimurium (23.6%) were the most common serotypes. Salmonella was a common foodborne pathogen in MENA countries, particularly in North African countries. Findings inform the scientific community, the public and the decision‐makers with Salmonella prevalence and gaps in evidence in MENA to support control and prevention strategies and could leverage more research studies.
Oral health outcomes for people with cerebral palsy: a scoping review protocol
Authors: Lansdown Karen , Smithers-Sheedy Hayley , Mathieu Coulton Kimberly , Irving Michelle 
Published: July 2019

ABSTRACT

Objective:
This review aims to systematically map the literature reporting on oral health outcomes experienced by people with cerebral palsy.

Introduction:
At present, there are no documented systematic reviews reporting on oral health outcomes for people of all ages with cerebral palsy. Subsequently, there are no clear guidelines, frameworks or detailed oral health recommendations for people with cerebral palsy. Considering the importance of oral health on general well-being and quality of life, it is important that it is not overlooked when focusing on patient-centered care for people with cerebral palsy.

Inclusion criteria:
Studies that focus on oral health, including dental diagnosis, trauma and/or treatment, facial pain, saliva, and sleep apnea, and/or make statements regarding oral health pertaining to cerebral palsy will be considered for inclusion inthis scoping review.

Methods:
This review will be conducted in accordance with the guidelines outlined by JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). Articles published in any language will be considered for inclusion, with no restriction on publication date. The search databases will include the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus, Embase and Dentistry and Oral Science. A search of gray literature will also be conducted. Extracted data relevant to the scoping review will be performed by two reviewers.
Notas sobre el derecho humano a la familia como derecho motor para el ejercicio de otros derechos humanos
Authors: Uribe Arzate Enrique , Bustamante Medrano Martha Guadalupe 
Published: July 2019

Actualmente, los derechos humanos enfrentan un difícil proceso de aproximación a su disfrute efectivo. En la doctrina y en la legislación, hay un notable desarrollo declarativo sobre los derechos humanos. Sin embargo, el gran problema tiene lugar cuando las personas intentan ejercerlos y disfrutarlos, porque no hay condiciones óptimas para esto.
Algunos de los derechos humanos “más esenciales” pueden volverse realidad, si los ubicamos en el contexto del derecho humano a la familia, que como nuevo derecho humano, tiene la capacidad para servir como derecho motor para el ejercicio de otros derechos humanos que no tienen mejor escenario para su disfrute que la familia.
Pseudo Credal Networks for Inference With Probability Intervals
Authors: Estrada-Lugo Hector Diego , Tolo Silvia , de Angelis Marco , Patelli Edoardo 
Published: July 2019

Abstract
The computation of the inference corresponds to an NP-hard problem even for a single connected credal network. The novel concept of pseudo networks is proposed as an alternative to reduce the computational cost of probabilistic inference in credal networks and overcome the computational cost of existing methods. The method allows identifying the combination of intervals that optimizes the probability values of each state of the queried variable from the credal network. In the case of no evidence, the exact probability bounds of the query variable are calculated. When new evidence is inserted into the network, the outer and inner approximations of the query variable are computed by means of the marginalization of the joint probability distributions of the pseudo networks. The applicability of the proposed methodology is shown by solving numerical case studies.
New geochronologic and paleomagnetic results from early Neoproterozoic mafic sills and late Mesoproterozoic to early Neoproterozoic successions in the eastern North China Craton, and implications for the reconstruction of Rodinia
Authors: Zhao Hanqing , Zhang Shihong , Ding Jikai , Chang Linxi , Ren Qiang , Li Haiyan , Yang Tianshui , Wu Huaichun 
Published: July 2019

Abstract
The interval from the late Mesoproterozoic to early Neoproterozoic is generally considered as a critical time for the amalgamation of Rodinia. The location of the North China Craton (NCC) in Rodinia remains contentious and demands greater paleomagnetic constraints. A combined geochronologic and paleomagnetic study was conducted on the late Mesoproterozoic to early Neoproterozoic rocks in the eastern NCC. Three sills were dated at ca. 945 Ma and one at ca. 920 Ma through use of the zircon U-Pb secondary ion mass spectroscopy method. Paleomagnetic investigation revealed no significant discrepancy between these sills. A positive baked-contact test, secular variation test and presence of reversals together support the primary origin interpretation for the remnant magnetization. A high-quality pole at (28.2 °S, 141.9 °E, A95 = 10.4°) was thus obtained by averaging our new results and a virtual geomagnetic pole previously reported for a ca. 920 Ma sill in the region. These Neoproterozoic sills intruded the successions that contain correlative strata that are named Nanfen, Xinxing, and Liulaobei formations in Liaoning, Jiangsu, and Anhui provinces, respectively. The Nanfen Formation and its equivalents are constrained between ca. 1120 and ca. 945 Ma by detrital zircons and the well-dated mafic sills. The paleomagnetic inclinations observed from the lower parts of the Nanfen, Xinxing, and Liulaobei formations are notably steep. The corresponding poles from these rock units are consistent and averaged at 38.6 °N, 136.7 °E (A95 = 3.2°). The quality of this pole is strengthened by a positive reversal test and its distinctiveness from the younger poles of the NCC. In the middle part of the Nanfen Formation, however, the paleomagnetic directions are characterized by moderate inclinations, being significantly different from those in the lower part of the Nanfen Formation and its equivalents. The calculated pole for the upper part of the Lower Member of the Nanfen Formation is at 8.0 °N, 128.5 °E (A95 = 7.9°). Another pole obtained from the Middle Member of the Nanfen Formation is at 11.2 °S, 127.7 °E (A95 = 8.5°). These two poles also differ from the younger poles of the NCC and likely represent the primary remanences. Our new results, together with the existing global paleomagnetic data and geological evidence, aided by the “right-way-up” connection model between Laurentia and Baltica in Rodinia, support a NCC–NW Laurentia connection between ca. 1120 and 890 Ma.
Use of complementary medicine products: a nationally representative cross-sectional survey of 2019 Australian adults
Authors: Harnett Joanna E , McIntyre Erica , Steel Amie , Foley Hope , Sibbritt David , Adams Jon 
Published: July 2019

ObjectivesTo provide a contemporary description of complementary medicine (CM) product use in Australia.DesignCross-sectional survey.SettingOnline.ParticipantsA nationally representative sample (n=2019) of the Australian adult population.Primary and secondary outcome measuresPrimary outcomes measures included the use and type of CM products used, and source of recommendation. Secondary measures included disclosure of CM product use to health practitioners, concomitant use of pharmaceuticals and predictors of use.ResultsPrevalence of CM product use was 50.3%, with the most frequently used being vitamin and mineral supplements (VMSs; 47.8%) and homoeopathic medicines the least used (6.8%). A majority of respondents using CM products were also using pharmaceutical products, and small but significant associations were found between the use of CM products and pharmaceuticals (p<0.05). Small statistically significant associations were found between use of vitamin products and disclosure of use to general practitioners (GPs; Cramer’s V=0.13, p=0.004) and hospital doctors (Cramer’s V=0.11, p=0.04), and between use of herbal medicines and disclosure to both GPs (Cramer’s V=0.11, p=0.02) and hospital doctors (Cramer’s V=0.12, p=0.03). Women, those with higher education and those with no private health insurance were more likely to use CM products (p<0.05), while those without chronic conditions were less likely to use CM products (p<0.05) (χ2(29)=174.70, p<0.001).ConclusionsThe number of Australians using CM products has remained relatively stable and substantial for nearly two decades. The majority of CM use relates to VMSs. Given the number of Australians using both CM products and pharmaceutical medicines, it is important to evaluate the potential clinical implications of such practices to ensure safe, effective and coordinated health policy and patient care.