bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity
Authors: Aghdashi Miramir , Salami Simak , Nezhadisalami Ahmad 
Published: August 2019

Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the current study aimed to discern evaluation of β2M in patients with SLE and its correlation with sickness activity.
Materials and Methods: In this case-control study, 50 patients with SLE disease and 25 healthy individuals were selected in Imam Khomeini Hospital in central of Urmia.
Blood samples were collected safely from patients, serum was removed, and β2M measured using an ELISA method. The results for other parameters including C reactive protein, C3, C4, anti dsDNA and erythrocyte sedimentation rate were obtained from patients’ medical record. Data analyzed using appropriate statistical tests including Mann-Whitney U test, Independent f-test, Kruskal-Wallis, and Spearman used for analysis of data.
Results: In the current study, a significant difference was seen between two groups in terms of β2M (p < 0.001). Remarkable correlation was seen between the level of β2M with disease activity (p < 0.001). Furthermore, there are significant relevancy between the level of β2M with 24-hour urine protein, ESR, disease activity score, and CRP (p < 0.05).
Conclusion: The results revealed that serum amount of β2M in SLE patients is higher compared to healthy ones, which is significantly correlated to score of illness activity, CRP, and ESR in patients with SLE disease. Hence β2M might be an excellent serological marker helping the prediction of sickness activity and inflammation in SLE patients.
The effect of nigellasativaoil on the prevention of phlebitis induced by chemotherapy: a clinical trial
Authors: Behnamfar Niaz , Parsa Yekta Zohreh , Mojab Faraz , Kazem Naeini Seyyed Mohammad 
Published: August 2019

Introduction: Phlebitis, that disrupts chemotherapy, is the inflammation of the vein and the most common complication of intravenous injection of chemotherapy drugs.Aim: the aim was determine the effect of topical application of N.sativaoil on the prevention of phlebitis caused by chemotherapy.Methods: This single-blind clinical trial was conducted on 60 cancer patients. In the intervention group, five drops of N.sativaoil was applied on the distal area of the catheter, two times per day and every 12 hours from the first day of chemotherapy to the third day; no intervention was conducted for the subjects in the control group.Results: Results showed that there was a significant difference between the two groups at 60 and 72 hours in regard with incidence of phlebitis. There was a statistically significant difference between the two groups at 12 and 72 hours in terms of severity (degree) of phlebitis.Conclusion: topical application of N.sativaoil is effective in the prevention of chemotherapy-induced phlebitis.
The judet quadricepsplasty for elderly traumatic knee extension contracture: a case report and review of the literature
Authors: Ding Benjamin Tze Keong , Khan Suheal Ali 
Published: August 2019

Traumatic injuries to the knee are frequently complicated by extension contractures. The Judet Quadricepsplasty allows for controlled, sequential release of extrinsic and intrinsic knee contracture components while reducing the potential for iatrogenic quadriceps rupture. We document our institutions experience with this procedure and a systematic review of the current literature. We followed up on an elderly patient with posttraumatic flexion contracture that failed conservative management and underwent Judet Quadricepsplasty. Her knee range of motion improve dramatically from 20 degrees of flexion to 100 degrees of flexion. There was a residual extension lag of 5 degrees which did not impede on the patients daily activities. A review of the literature was performed and relevant data from 12 articles was extracted. The procedure was mainly performed in young adult males in most previous studies and the range of motion improvement ranged from 51° to 110°. Wound infections were the most common complication but otherwise other complications and severe extension lag were rare. The Judet Quadricepsplasty is a useful procedure for severe extension knee contractures that has failed conservative management in all age groups of patients. It is associated with significant increases in range of motion with low rates of complication or extension lag.Diagnostic IV
Untersuchung der Messgenauigkeit verschiedener Blutglukosemesssysteme, erworben in Discountern und Drogeriemärkten im Rahmen der Versorgungsforschung in Anlehnung an ISO 15197
Authors: Baumstark Annette , Jendrike Nina , Pleus Stefan , Waldenmaier Delia , Zschornack Eva , Link Manuela , Kamecke Ulrike , Mende Jochen , Freckmann Guido 
Published: August 2019

Zusammenfassung
Einleitung Blutglukosemesssysteme (BGMS) zur Eigenanwendung ermöglichen eine selbstständige Stoffwechselüberwachung und eine flexible Therapieanpassung. Auf der Grundlage der gemessenen Blutglukosewerte werden von den Anwendern Entscheidungen über Mahlzeiteneinnahme und Insulindosis getroffen. Die Messgenauigkeit von BGMS sollte daher nicht vernachlässigt werden. BGMS sind heutzutage neben der Apotheke oder dem Fachhandel auch in Supermärkten, Discountern oder Drogeriemärkten erhältlich.Im Rahmen der herstellerunabhängigen Versorgungsforschung wurde in dieser Untersuchung die Systemgenauigkeit von 4 BGMS, erworben in Discountern oder Drogeriemärkten, bewertet. Es wurde jeweils eine Teststreifencharge in Anlehnung an die Prozedurvorgaben der EN ISO 15197:2015 getestet. Die Messungen wurden in den Jahren 2016 und 2017 durchgeführt.
Methodik Mit je einer Teststreifencharge der 4 Systeme wurden 100 Kapillarblutproben mit der in der Norm geforderten Glukosekonzentrationsverteilung in Doppelbestimmung gemessen. Die ausgegebenen Werte wurden den Ergebnissen der Herstellerreferenzmethode (Glukoseoxidase) gegenübergestellt. Nach EN ISO 15197:2015 müssen ≥ 95 % der Messergebnisse innerhalb von ± 15 mg/dl bzw. ± 15 % der Vergleichsmessergebnisse bei einer Glukosekonzentration < 100 mg/dl bzw. ≥ 100 mg/dl liegen (Kriterium A). Die klinische Relevanz der Messabweichungen wurde, wie in der Norm beschrieben, mithilfe eines Consensus Error Grid (CEG) ermittelt (Kriterium B).
Ergebnisse Angewendet auf eine Teststreifencharge, erfüllte keines der untersuchten Systeme das Kriterium A der Systemgenauigkeitsanforderungen. Jeweils 55,5 % (System A), 90,0 % (System B), 66,5 % (System C) und 75,5 % (System D) der Werte lagen innerhalb der Grenzen ± 15 mg/dl/ ± 15 %.Bei drei Systemen lagen alle Werte in den Zonen A und B des CEG (Kriterium B). Von den gemessenen Werten des vierten Systems befanden sich 5 Werte in der CEG-Zone C („Wahrscheinlichkeit für Beeinträchtigung des klinischen Ergebnisses“), die übrigen Werte lagen innerhalb der akzeptablen Zonen A und B. Der relative Bias lag bei + 16,2 % (System A), –8,4 % (System B), –13,9 % (System C) und + 9,5 % (System D).
Schlussfolgerung In dieser Studie hat keines der untersuchten BGMS mit der getesteten Teststreifencharge die angewandten Messgenauigkeitskriterien der ISO 15197 erfüllt. Die Ergebnisse bestätigen, dass herstellerunabhängige Kontrollen der Messqualität der im Handel erhältlichen BGMS wichtig sind, um für Menschen mit Diabetes mellitus eine sichere Therapie zu gewährleisten.
Endovascular and Percutaneous Treatment of Pediatric Portosystemic Varices: A Case Review
Authors: Dabrowiecki Alexander , Monroe Eric J. , Romero Rene , Gill Anne E. , Hawkins C. Matthew 
Published: August 2019

AbstractPortal hypertension is a significant cause of morbidity and mortality in pediatric patients. Complications of portal hypertension include development of portosystemic varices. The most common type of portosystemic varices are gastroesophageal varices; however, other ectopic varices can also be a cause of recurrent, life-threatening gastrointestinal bleeding. Problematic ectopic varices include isolated gastric, anorectal, small bowel, roux-limb, and stomal varices. There are no standardized treatment guidelines on how to manage ectopic varices in children; however, new innovations in endovascular treatment options provide potential therapeutic alternatives when varices are refractory to conventional therapy. This review provides a case-based literature review for endovascular treatment of isolated gastric, anorectal, small bowel, roux-limb, and stomal ectopic varices in children (age 0-9 years) and adolescents (age 10-19 years).
Intraoperative Hypertensive Urgency and Hemodynamic Instability during Microvascular Decompression for Trigeminal Neuralgia
Authors: Jayapaul Pushkaran , Rajan Thanga T. , Sabeson Aravind 
Published: August 2019

Abstract
Objective To evaluate the factors predisposing to rare events of intraoperative hypertensive urgency during microvascular decompression (MVD) for trigeminal neuralgia (TGN) and outcome of MVD on long-term blood pressure (BP) control.
Patients and Methods Total 54 consecutive TGN patients who failed medical management in two institutions from January 2012 to January 2017 were included in the study. MVD of TGN was done through retromastoid suboccipital craniotomy. Intraoperative “hypertensive urgency” and hemodynamic instability were observed in two patients with BP shooting up to > 180/120 mm Hg, which was controlled. Postoperative period was uneventful and patients were discharged. Patients were reviewed in the OPD clinic at 1 and 6 months after discharge and their clinical status was evaluated. The collected data were analyzed retrospectively.
Results Of the 54 patients, 32 (59.26%) were male and 22 (40.74%) were female. Twenty-five (46.30%) patients were hypertensive, out of whom 19 (76%) were in Joint National Committee (JNC) 7 stage 1 and 6 (24%) were in stage 2. Two (3.70%) patients had an intraoperative hypertensive crisis, and in both the patients, the offending vessel was an atheromatous ectatic vertebrobasilar artery. Postoperative long-term BP control or normalization was observed in one of the two patients with a single antihypertensive drug who was on three antihypertensive drugs preoperatively.
Conclusion Intraoperative hypertensive urgency is a medical emergency that can be encountered in MVD surgery for TGN, and an ectatic atheromatous vertebrobasilar arterial compression on the nerve is notorious for predisposing to hypertensive urgency. Postoperative long-term BP control in hypertensive patients is not feasible after MVD in this study, which needs further detailed analysis.
Learning scientific creativity from the arts
Authors: Lehmann Johannes , Gaskins Bill 
Published: August 2019

AbstractExamining scientific creativity through the lens of artistic practice may allow identification of a path towards an institutional environment that explicitly values and promotes transformative creativity in science. It is our perception as an artist and natural scientist that even though creativity is valued in the sciences, it is not institutionally promoted to the same extent it is in the arts. Acknowledging creativity as acts of transformation and central to scientific pursuit, actively utilizing chance and failure in scientific experimentation, are critical for step changes in scientific knowledge. Iterative and open-ended processes should be modeled after insights from a range of practices in the visual, performing and media arts. Successful institutional implementation requires training through a long-term process of unlearning and learning, organizing interactions to critique results, designing experiments to contain trial and error, and building common and individual spaces that promote chance encounters across disciplines and with non-academic sectors. As a natural scientist and an artist, we call for bringing such a transformative creative approach into scientific practice as a guiding principle for organizational and cultural development of the university.
Creating and communicating social research for policymakers in government
Authors: Phoenix Jessica H. , Atkinson Lucy G. , Baker Hannah 
Published: August 2019

AbstractMany academics ask ‘How can I use my research to influence policy?’. In this paper, we draw on our first-hand experience as social researchers for the British Government to advise how academics can create and communicate research with policymakers. Specifically, we describe methods of communicating research to policymakers in relation to research we undertook to listen to farmers about their priorities for a new agricultural policy for England following the exit of the UK from the European Union. The main purpose of this research was to ensure farmers’ voices were included in policy development and therefore communication of the research to policymakers was key. We reflect on the effectiveness of the communication methods we employed and summarise our learnings into four practical recommendations: (1) make research relevant to policymakers; (2) invest time to develop and maintain relationships with policymakers; (3) utilise ‘windows of opportunity’; and (4) adapt presentation and communication styles to the audience. We consider that employing these recommendations will help to improve how evidence is communicated between academia and government and therefore the influence of evidence in decision-making processes.
Reflective prolate-spheroidal operators and the KP/KdV equations
Authors: Casper W. Riley , Grünbaum F. Alberto , Yakimov Milen , Zurrián Ignacio 
Published: August 2019

Significance
Pairs of commuting integral and differential operators have been constructed on a case-by-case basis in the analysis of various spectral problems in signal processing, random matrix theory, and integrable systems. We present a unified general construction of commuting pairs based on the intrinsic properties of symmetries of soliton equations. A key ingredient in it is a method proving that the integral operators associated to the points of infinite-dimensional families of solutions of soliton equations canonically “reflect” differential operators. This in turn is used to give examples of interesting commuting pairs.
The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors
Authors: Zhu Fangfang , Feng Mingye , Sinha Rahul , Murphy Matthew Philip , Luo Fujun , Kao Kevin S. , Szade Krzysztof , Seita Jun , Weissman Irving L. 
Published: August 2019

Significance
GABA not only plays critical roles in the central nervous system but also is involved in various peripheral tissues, such as intestine, stomach, etc. Here, we tried to identity the function of GABA signaling in hematopoietic progenitors. We found GABRR1 is the only GABA receptor expressed in subsets of both human and mouse hematopoietic stem cells and megakaryocyte progenitors. Further studies showed inhibition of GABRR1 with a knockout mouse model, CRISPR-mediated deletion, or GABA antagonist treatment inhibited megakaryocyte and platelet differentiation, while activation of GABRR1 through lentivirus-mediated overexpression or GABA agonist treatment promoted platelet generation. Thus, our work identifies a link between this neural receptor and the hematopoietic system and potentially uncovers a strategy to efficiently generate megakaryocytes and platelets.
Patterns, constructions, and applied linguistics
Authors: Hunston Susan 
Published: August 2019

AbstractThis paper proposes an alignment between aspects of pattern grammar (Francis, 1993;Hunston & Francis, 2000) and construction grammar (Goldberg, 2006). Pattern Grammar describes the grammatical behaviour of individual words at a specific level of generality. The paper claims that grammar patterns and the groups of words identified as occurring with them can be used to propose candidate constructions. This claim is illustrated with verbs and with adjectives. The paper proposes that the term ‘construction’ be used to refer to a sub-set of instances of a grammar pattern, that sub-set identified by the occurrence of a limited set of node words. It also proposes that the Pattern Grammar reference resources that are already available be reconfigured as a constructicon. The paper discusses how constructions could be presented to (English) language teachers and learners and how a constructicon might be organised.
Short-term accommodation as a function of addressee language proficiency
Authors: Corbett Cecily 
Published: August 2019

AbstractThis paper examines patterns of phonetic accommodation as a function of addressee target language proficiency. Specifically, it analyzes short-term adjustments in the articulation of coda consonants /s/, /ɾ/, and /n/ in the speech of eight New York Dominican Spanish speakers during a series of conversations with different addressees – a native speaker and three nonnative Spanish speakers who have varying levels of Spanish proficiency. Results demonstrate that addressee native-speaker status and proficiency play a statistically significant role in both the degree and direction of phonetic accommodation exhibited by the native speaker informants. While the informants converge with both the most- and least-proficient addressees, they initially diverge from the mid-proficient addressee. The study finds that the native speaker informants use overtly-prestigious variants to attune to the academic Spanish of the most-proficient addressees and use covertly-prestigious, emblematic variants with both the mid-proficient and native speaker addressees to demonstrate outgroup and ingroup membership, respectively.
Los marcadores del discurso
Authors: Landone Elena 
Published: August 2019

ResumenEl objetivo de este estudio es investigar si los marcadores del discurso (MD) (comohombre, bueno, etc.) pueden aportar información verbal que despierte las inferencias de los hablantes sobre la relación emotiva que surge en una conversación. Se adopta una metodología émica, que consiste en obtener la percepción de la emoción de los sujetos en doscorpusparalelos de diálogos (español e italiano). Los resultados demuestran que algunos MD funcionan realmente como índices inferenciales emotivos, pero varían según el hablante y son altamente dependientes del contexto.
Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma
Authors: Jang Su Chul , Crescitelli Rossella , Cvjetkovic Aleksander , Belgrano Valerio , Bagge Roger Olofsson , Sundfeldt Karin , Ochiya Takahiro , Kalluri Raghu , Lötvall Jan 
Published: August 2019

ABSTRACTExtracellular vesicles (EVs), including exosomes and microvesicles, are secreted from all cells, and convey messages between cells in health and disease. However, the diversity of EV subpopulations is only beginning to be explored. Since EVs have been implicated in tumour microenvironmental communication, we started to determine the diversity of EVs specifically in this tissue. To do this, we isolated EVs directly from patient melanoma metastatic tissues. Using EV membrane isolation and mass spectrometry analysis, we discovered enrichment of mitochondrial membrane proteins in the melanoma tissue‐derived EVs, compared to non‐melanoma‐derived EVs. Interestingly, two mitochondrial inner membrane proteins MT‐CO2 (encoded by the mitochondrial genome) and COX6c (encoded by the nuclear genome) were highly prevalent in the plasma of melanoma patients, as well as in ovarian and breast cancer patients. Furthermore, this subpopulation of EVs contains active mitochondrial enzymes. In summary, tumour tissues are enriched in EVs with mitochondrial membrane proteins and these mitochondrial membrane proteins can be detected in plasma and are increased in melanoma, ovarian cancer as well as breast cancer.
Analysis of Changes Settlement and Fair Market Land Prices to Predict Physical Development Area Using Cellular Automata Markov Model and SIG in East Ungaran Distric
Authors: Subiyanto S , Amarrohman F J 
Published: August 2019

Abstract
East Ungaran District has various forms of land use, from the many important land uses ranging from settlements, industry, roads and other public facilities. Over time, land use will have changes along with existing development. The development of the Semarang - Solo toll road in 2009 by PT Jasa Marga (Persero) Tbk and of changes the land use in the district and sub-district of West Ungaran, East Ungaran post-expansion area in 2003 is the factors causing land use change in East Ungaran Distric also conducted Analysis. East Ungaran District is one of the areas with the rapid development of the distric. This is the result of increased population and population mobility. Because of these factors, there is a growth of development as well as changes in settlemen that lead to the physical changes of the city. Based on above, it is necessary to research the settlement change in East Ungaran Distric. The method used to determine the hierarchy of rural and urban settlements with characteristics of the region which has the main function of cultivation of the livelihoods of its inhabitants, population density, facilities and infrastructure, the dominance of a broad percentage of land use. The method used to determine determine the direction pattern of the physical development of the the settlement area is Global Moran’s Index while to predict the physical development of the East Ungaran Distric area in 2026 used CA Markov method. This research used high-resolution imagery in 2010 and 2018, and land use maps in 2002, 2010 and 2018. The data were used to analyze the settlement change. Meanwhile, the analysis of changes in land values using the land value zones map of 2002, 2010 and land value zones map of 2018 obtained from field survey results. This method will be assisted with field observations conducted in 2018, with the aim of giving an overview use changes that occur from these results, analyzed the effect of the settlement change on land value change in East Ungaran District as a result of Semarang - Solo toll road development.
Analysis of Landslide Susceptibility of Belandingan Village, Songan A Village and Songan B Village of Kintamani, Bangli, Indonesia
Authors: Pradnyasari N M D , Wiyanti  , Kusmawati T 
Published: August 2019

Abstract
The research conducted in order to find out how the susceptibility for landslides in the village of Belandingan, Songan A Village and Songan B Village. Scoring and overlay method used to determine the results of landslide susceptibility in the study area. Parameter used as the basis for overlay and scoring are soil types, rainfall data, structural geology, landform, slope and land use map. From the overlay result, 41 land unit were mapped on the research area. Based on scoring and GIS analysis, there are 4 classes of landslide susceptibility including not susceptible, low susceptibility, moderate susceptibility and high susceptibility. Most area of study area are are included as low susceptibility and medium susceptibility. Meanwhile high susceptibility mainly concentrated on the ancient caldera on west part of Batur Lake. Belandingan, Songan A and Songan B villages have various levels of landslide susceptibility, starting from this non-susceptible category, covering land units 34 and 39. Low susceptibility on land units 26, 29, 25, 23, 21, 38, 3, 12 and 11. While on land units 36, 30, 31, 32, 14, 15, 16, 17, 19, 4, 20, 40, 24, 6, 13, 2, 37, 7, 8, 9, 27.10, 22, 41, 1.5 and high susceptibility on land units 33, 18, 35, 28. The no susceptibility class mainly located in Songan A and Songan B Village with total area 94,405 Ha. Low susceptibility class are located mainly in Songan A Village with small amount in Songan B Village with total area 1196.768 Ha. Moderate susceptibility class located in all with total area 1866.346 Ha. High landslide susceptibility class located mainly in Songan B Village with small amount in Belandingan Village and Songan A Village with total area 339,979 Ha.