bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Fluorescence Spectroscopy Along with Mathematical Modeling for Rapid Prediction of Adulteration in Cooked Minced Beef Meat
Authors: Saleem Asima , Imtiaz Aysha , Yaqoob Sanabil , Awais Muhammad , Awan Kanza Aziz , Naveed Hiba , Khalifa Ibrahim , Al‐Asmari Fahad , Qian Jian‐Ya 
Published: November 2024

ABSTRACTThis study explores the potential of fluorescence spectroscopy (FS), coupled with principal component analysis (PCA) and partial least square regression (PLSR), to detect meat adulteration rapidly and non‐destructively in cooked minced beef. We aimed at evaluating FS as a simple and efficient tool for identifying cheaper meat species, that is chicken, used as adulterants in beef. Fluorescence spectra were collected at one fixed emission wavelength (410 nm) and three excitation wavelengths (290, 322, and 340 nm) from both pure and adulterated cooked meat samples. Adulteration levels ranging from 10% to 90% were assessed by mixing chicken meat with beef, followed by fluorescence analysis. The results indicated that the PCA model explained 100% of the variance, with 96% accounted for by the first principal component, showing clear discrimination between pure and adulterated samples. PLSR models demonstrated excellent predictive accuracy, with cross‐validated coefficients of determination of 0.95, highlighting FS's capability in distinguishing between pure and adulterated meats even after cooking. The cross‐validated grouping success rate was ~97%, reinforcing the reliability of the technique. This study represents the first investigation using FS to predict adulteration in cooked meat, providing a benchmark for future research. The findings suggest that FS, in combination with mathematical modeling, holds great promise as a rapid, cost‐effective, and nondestructive method for detecting meat adulteration, with significant potential for practical application in food industry quality control.
The anticholinergic burden in patients with chronic kidney disease: Patterns, risk factors, and the link with cognitive impairment
Authors: Mouheb Agathe , Levassort Hélène , Massy Ziad A. , Jacquelinet Christian , Laville Maurice , Alencar de Pinho Natalia , Pépin Marion , Laville Solène M. , Liabeuf Sophie ,   the Chronic Kidney Disease‐Renal Epidemiology and Information Network (CKD‐REIN) Study Group
Published: November 2024

AbstractBackgroundPeople with chronic kidney disease (CKD) have an elevated risk of cognitive impairment (CI). Medications with anticholinergic activity are recognized for their adverse reactions on central nervous system. The putative association between the anticholinergic burden and CI has not previously been evaluated in patients with CKD. The study aimed to (i) describe prescriptions of medications with anticholinergic activity, (ii) analyze factors associated with these prescriptions, and (iii) evaluate the anticholinergic burden's association with cognitive performance.MethodsCKD‐REIN, a prospective cohort study, enrolled nephrology outpatients with a confirmed diagnosis of CKD (eGFR <60 mL/min/1.73m2). Drug prescriptions were recorded prospectively during the 5‐year follow‐up. Mini Mental State Examination (MMSE) was assessed at baseline and CI was defined as an MMSE score <24/30. For each patient, the anticholinergic burden was determined by summing the Anticholinergic Cognitive Burden (ACB) scores of all prescription drugs at baseline. Multinomial logistic regression was used to analyze factors associated with the ACB score. Logistic regression was used to evaluate the association between the cognitive impairment and the anticholinergic burden at baseline.ResultsAt baseline, 3007 patients (median age [IQR], 69[60–76]; 65% men) had MMSE data and were included. 1549 (52%) of these patients were taking at least one drug with anticholinergic properties. Most (1092; 70%) had a low anticholinergic burden, 294 (19%) had a moderate anticholinergic burden, and 163 (11%) had a high anticholinergic burden. A history of neurological/psychiatric disorders and a higher number of daily drugs were associated with a greater probability of having a high anticholinergic burden (odds ratio (OR) [95% confidence interval (95% CI)] = 1.88[1.29;2.74] and 1.53[1.45;1.61], respectively). Patients with a high anticholinergic burden had a significantly higher probability of presenting cognitive impairment, compared with patients without an anticholinergic burden (OR[95% CI] = 1.76[1.12;2.75]) after adjustment for sociodemographic factors, comorbidities, laboratory data, and the number of medications taken daily.ConclusionsThe results of our study emphasize the need for caution in the prescription of drugs with anticholinergic properties to patients with CKD.
A Well‐Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16‐Week Controlled Study
Authors: Turlier Virginie , Froliger Mélanie , Ribet Virginie , Mengeaud Valérie , Reygagne Pascal 
Published: November 2024

ABSTRACTBackgroundChronic telogen effluvium (CTE) is characterized by hair loss lasting for more than 6 months and severely impairs quality of life (QoL). There is no specific treatment.AimsTo assess the dermatological tolerance and clinical efficacy of a hair serum containing three plant‐derived active ingredients (a Silybum marianum extract, Manganese PCA, and a Lespedeza capitata extract) in women with CTE.MethodsIn this 16‐week, open‐label, two‐arm, controlled, parallel‐group study, 64 women aged 46 ± 10 years with CTE and a positive hair pull test were allocated equally to either a treated group (study serum and neutral shampoo) or a control group (neutral shampoo only).ResultsThe investigator rated dermatological tolerance of the serum as good at week (W)16. Compared to the control group, reductions in the amount of hair collected by the investigator during hair pull tests were greater in the treated group at W8 (p = 0.027) and W16 (p = 0.030), the amount of hair shed in 60 s (assessed by the subjects) was significantly lower in the treated group from W4, and more subjects in the treated group reported a decrease in hair loss over the study period (p ≤ 0.01; all time points). The treated subjects also perceived a significant improvement in hair volume, density, strength, and thickness, and reported being less depressed, less annoyed and less embarrassed by their hair loss.ConclusionsThe serum was well‐tolerated and had a significant anti‐hair loss effect in women with CTE. This effect positively impacted QoL.
Remnant ureter abscess linked to obstructed hemivagina and ipsilateral renal anomaly syndrome
Authors: Kaneko Meika , Ishikawa Hiroshi , Kaneko Takaoki , Sato Asuka , Shozu Makio , Koga Kaori 
Published: November 2024

AbstractPatients with obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome sometimes present with distinct symptoms related to coexisting urogenital abnormalities. We present a case of refractory abscess formation in a blind‐ended remnant ureter associated with ipsilateral renal agenesis. A 15‐year‐old patient with OHVIRA syndrome, who had a blind‐ended remnant ureter, underwent obstructed hemivagina opening 18 months after menarche due to heavy genital bleeding and abdominal pain after the end of menstruation. Four years later, the patient presented with recurring fever and abdominal pain due to a refractory abscess in the ureter. Although the continuity between the ureter and the previously opened hemivagina was not identified, the same bacteria were detected in the abscess and vaginal discharge, indicating that an ascending bacterial infection of the vagina may cause refractory abscess formation in a blind‐ended remnant ureter. Open ureterectomy with partial bladder resection was needed to resolve the symptoms.
Growth Monitoring and Promotion Service Utilization and Associated Factors Among Mothers/Caregivers of Children 0–23 Months in Sude District, Southeast Ethiopia
Authors: Edae Birbirsa Sheri , Yazew Tamiru , Disasa Hiwot Dejene , Kuyu Chala G. 
Published: November 2024

ABSTRACTInadequate physical growth and poor development are significant global challenges affecting millions of children. Globally, 149.2 million children under five experience stunted growth and 45.4 million suffer from wasting. Growth monitoring and promotion (GMP) programmes aim to identify growth faltering in children before they develop malnutrition. However, understanding the factors influencing GMP service utilization is crucial for improving its effectiveness in the study area. This community‐based cross‐sectional study in the Sude district of southeastern Ethiopia investigated GMP service utilization among mothers of children aged 0–23 months. The study included 874 participants selected through systematic random sampling. Data collected through a structured questionnaire revealed a GMP service utilization rate of 40.2%. The study identified several factors significantly associated with GMP service utilization. This includes maternal education, husband involvement, institutional delivery, maternal autonomy and birth interval, which are the most significant factors identified to influence GMP service utilization. Mothers with higher levels of education were more likely to utilize GMP services [AOR = 3.70 (95% CI: 2.09, 6.54)]. Discussions about child growth with husbands were linked to increased GMP utilization [AOR = 2.22 (95% CI: 1.24, 3.968)]. Moreover, mothers who delivered at health facilities and with greater autonomy in decision‐making showed higher GMP utilization with [AOR = 1.83 (95% CI: 1.23, 2.72)] and [AOR = 3.79 (95% CI: 2.41, 5.96), respectively. Mothers with longer birth intervals were also more likely to utilize GMP services [AOR = 1.947 (95% CI: 1.39, 2.73)]. The study highlights the importance of addressing these factors to increase GMP service utilization and improve child health outcomes in the study area. Behavioural change communication programmes targeting fathers can promote their engagement in child growth discussions. Moreover, empowering women to make decisions about their children's health and access to healthcare services and promoting open communication within families about child growth and development can raise awareness and support for GMP services. Addressing these factors through targeted interventions will promote GMP utilization and improve child growth and development.
Extreme Environmental Variability Induces Frontloading of Coral Biomineralisation Genes to Maintain Calcification Under pCO2 Variability
Authors: Brown Kristen T. , Dellaert Zoe , Martynek Marcelina P. , Durian Julia , Mass Tali , Putnam Hollie M. , Barott Katie L. 
Published: November 2024

ABSTRACTCorals residing in habitats that experience high‐frequency seawater pCO2 variability may possess an enhanced capacity to cope with ocean acidification, yet we lack a clear understanding of the molecular toolkit enabling acclimatisation to environmental extremes or how life‐long exposure to pCO2 variability influences biomineralisation. Here, we examined the gene expression responses and micro‐skeletal characteristics of Pocillopora damicornis originating from the reef flat and reef slope of Heron Island, southern Great Barrier Reef. The reef flat and reef slope had similar mean seawater pCO2, but the reef flat experienced twice the mean daily pCO2 amplitude (range of 797 v. 399 μatm day−1, respectively). A controlled mesocosm experiment was conducted over 8 weeks, exposing P. damicornis from the reef slope and reef flat to stable (218 ± 9) or variable (911 ± 31) diel pCO2 fluctuations (μatm; mean ± SE). At the end of the exposure, P. damicornis originating from the reef flat demonstrated frontloading of 25% of the expressed genes regardless of treatment conditions, suggesting constitutive upregulation. This included higher expression of critical biomineralisation‐related genes such as carbonic anhydrases, skeletal organic matrix proteins, and bicarbonate transporters. The observed frontloading corresponded with a 40% increase of the fastest deposited areas of the skeleton in reef flat corals grown under non‐native, stable pCO2 conditions compared to reef slope conspecifics, suggesting a compensatory response that stems from acclimatisation to environmental extremes and/or relief from stressful pCO2 fluctuations. Under escalating ocean warming and acidification, corals acclimated to environmental variability warrant focused investigation and represent ideal candidates for active interventions to build reef resilience while societies adopt strict policies to limit climate change.
Iran and Her Ethicists: A Critical Perspective
Authors: Chamankhah Leila 
Published: November 2024

AbstractThis paper investigates the continuation of Ibn ʿArabī's doctrine of takhalluq bi akhlāq Allāh in the writings of his Iranian expositors in the post‐Ṣadrā era until present. Typical of classical Islamic culture, according to which Man will reach perfection when he is adorned with divine ethics, takhalluq gains a new twist in the writings of Ibn ʿArabī's predecessors, chief among them the Algerian Sufi Aḥmad Ibn ʿAlī al‐Būnī (d. 1230?), who disccuseed the topic in a nuanced way. In line with Būnī and other like‐minded Sufis, al‐Shaykh al‐Akbar discusses the triad of takhalluq, taʿalluq and taḥaquq in several of his writings, including a book with the same title, Kashf ul‐maʿnī ʿan sirr‐i asmāʾ ul‐Allah al‐ḥusnā (the Unveiling of the Meaning from the Secret of the Beautiful Names). If intellectual history is an inquiry that focuses on the role of ideas in the thinking and actions of the human being, the present research first reads and analyzes the writings of a number of Ṣadrīan philosophers to debate the ways in which they undertood the discourse of takhalluq bi akhlāq Allāh. Secondly, it will investigate how their contributions to this legacy have left their imprint on the configuration of politics in post‐revolutionary Iran. The ethicists of takhalluq have been more influential than one imagines in shaping public and political life since 1979 onwards.
Characteristics of Patients With Asymptomatic Atrial Fibrillation and Ischemic Stroke—Insights From the GLORIA‐AF Registry (Phase 2)
Authors: Heer Tobias , Zeymer Uwe , Schwarzbach Christopher J. , Seidl Karlheinz , Rauch‐Kröhnert Ursula , Marler Sabrina , Teutsch Christine , Diener Hans‐Christoph , Senges Jochen , Lip Gregory Y. H. , Huisman Menno V. ,   the GLORIA‐AF Investigators
Published: November 2024

ABSTRACTBackgroundAsymptomatic nonvalvular atrial fibrillation is often suspected in patients with cryptogenic stroke which constitute 20%–30% of ischemic strokes. Detection of atrial fibrillation (AF) and treatment with anticoagulation can reduce the risk of stroke. We sought to investigate the prevalence of asymptomatic atrial fibrillation (aAF) in patients with a history of stroke or an acute stroke on admission.MethodsFrom November 2011 until December 2014, 15,308 patients with a first episode of AF were enrolled in phase 2 of the international, prospective, multicenter global registry on long‐term oral anticoagulation treatment in patients with AF (GLORIA‐AF) Registry. For the present analysis, we focused on patients with aAF regarding the prevalence of stroke.ResultsOne third of patients (n = 4892, 32%) had aAF. Of these, 611 (12.5%) had a history of stroke or an acute stroke on admission. In contrast, 519 of 10,416 (5.0%) patients with symptomatic AF (sAF) had a history of stroke or an acute stroke on admission. Higher age, male gender, permanent AF, stroke, and the combination of stroke, TIA or systemic embolism were associated with a higher prevalence of aAF on admission. In a multivariable analysis, patients with aAF had a 2.3‐fold (95% confidence interval (CI), 2.02–2.54) risk for stroke compared to patients with sAF. Other independent risk factors for stroke were a history of prior bleeding (odds ratio 1.62, 95% CI, 1.34–1.92), chronic kidney disease (1.38, 1.21–1.56), and diabetes mellitus (1.24, 1.10–1.41).ConclusionaAF is reported in about one third of patients with newly diagnosed AF and is associated with a 2.3‐fold risk for stroke compared to sAF. Therefore, screening for aAF in high‐risk patients might be appropriate to prevent further embolic cerebrovascular events.
dciWebMapper: A Data‐Driven and Coordinated View‐Enabled Interactive Web Mapping Framework for Visualizing and Sensing High‐Dimensional Geospatial (Big) Data
Authors: Sarigai Sarigai , Yang Liping , Slack Katie , Lane K. Maria D. , Buenemann Michaela , Wu Qiusheng , Woodhull Gordon , Driscol Joshua 
Published: November 2024

ABSTRACTWe are surrounded by overwhelming big data, which brings substantial advances but meanwhile poses many challenges. A very large portion of big data contains geospatial information and hence geospatial big data, which is crucial for decision making if being utilized strategically. Among others, volumes in size and high dimensions are two major challenges that prevent strategic decision making from geospatial big data. Interactive map‐based and geovisualization enabled web applications are intuitive and useful to construct knowledge. More importantly, such interactive web map applications are powerful to intuitively reveal insights from high‐dimensional geospatial big data for actionable decision making. We propose an interactive and data‐driven web mapping framework, named dciWebMapper, for visualizing and sensing high‐dimensional geospatial (big) data in an interactive and scalable manner. To demonstrate the wide applicability and usefulness of our framework, we have applied our dciWebMapper framework to three real‐world case studies and implemented three corresponding web map applications: iLit4GEE‐AI, iWURanking, and iTRELISmap. We expect and hope the three web maps demonstrated in different domains, from literature big data analysis to world university ranking to scholar mapping, will provide a good start and inspire researchers and practitioners in various domains to apply our dciWebMapper to solve and/or aid in solving impactful problems.
Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013–2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee
Authors: Lee Dong Heun , Abidi Maheen Z. , Fisher Cynthia , Hughart Anna L. , Toda Mitsuru , Williams Samantha , Berry Gerald J. , Graves Riki , Handarova Dzhuliyana , Ho Chak‐Sum , Kittleson Michelle , Levi Marilyn E. , Livelli Taylor , Marboe Charles C. , Annamabhotla Pallavi , Miller Rachel A. , Sharma Tanvi , Sellers Marty T. , Taimur Sarah , Te Helen S. , Trindade Anil J. , Wood R. Patrick , Zaffiri Lorenzo , Pouch Stephanie M. , Danziger‐Isakov Lara 
Published: November 2024

ABSTRACTBackgroundCoccidioidomycosis is a fungal infection that poses a serious risk when transmitted through organ transplantation. We analyzed cases reported to the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee from 2013 to 2022.MethodsDonors and/or recipients who had positive Coccidioides immitis/posadasii serology, pathology, and/or culture were included in this study. Cases adjudicated as ‘proven’ or ‘probable’ were analyzed for donor infection risk factors, the timing of infection, transmission by organ type, clinical manifestations, and recipient outcomes. Patient and facility identifiers were removed prior to review.ResultsDuring this time period, 73 potential instances of Coccidioides donor disease transmission events were reported. Among them, infection was transmitted from seven deceased donors to eight recipients. All seven deceased donors had prior infection or exposure to regions where coccidioidomycosis is endemic. Of 20 individuals receiving organs from these donors, eight developed infection, resulting in a 40% transmission rate. The median time to diagnosis post‐transplant was 39 days. Disseminated disease occurred in six recipients, five of whom died from the infection. Notably, none of the recipients who received prophylactic antifungal treatment died from the infection.ConclusionDespite its rarity, donor‐derived Coccidioides infection is a serious concern, particularly due to the high mortality rate in the early post‐transplant period. To mitigate these risks, a thorough assessment of donor exposure history, coupled with donor serology and bronchoalveolar lavage cultures, can effectively guide post‐transplant antifungal prophylaxis. Prompt reporting is crucial to prevent Coccidioides infections among other recipients.
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Estimated Median Waiting Time for Organ Procurement and Transplantation Network Human Immunodeficiency Virus Organ Policy Equity Act Variance Kidney Candidates: A Propensity Score Matched Analysis
Authors: Fritz Amber R. , Howell Jesse , Wolfe Cameron R. , Noreen Samantha M. , Klassen David K. 
Published: November 2024

ABSTRACTBackgroundPrior to the 2013 HIV Organ Policy Equity (HOPE) Act, which enabled research on the transplantation of solid organs from donors with human immunodeficiency virus (HIV) to candidates living with HIV, it was prohibited for HIV+ individuals to donate organs in the United States. In 2015, alongside the release of HOPE Act research criteria, the Organ Procurement and Transplantation Network (OPTN) made organ allocation policy and system changes to allow HIV+ to HIV+ transplantation.MethodsThe OPTN database was queried for all adult kidney registrations ever waiting from November 23, 2015, to December 31, 2022; the cohort was split into a HOPE cohort (ever willing to accept an HIV+ kidney) and a non‐HOPE cohort (all remaining). Estimated median waiting times (eMWTs) were calculated using a period prevalent Kaplan‐Meier approach; HOPE registrations were matched 1:5 without replacement to non‐HOPE registrations using a logistic regression propensity score.ResultsUsing all waiting time, the eMWT for the HOPE cohort was significantly lower than the matched non‐HOPE cohort (3.04 years [95% confidence interval {CI}: 2.70, 3.41] versus 5.88 years [95% CI: 5.65, 6.18]). This trend persisted when estimating MWT using other active time and geographical definitions (ignoring geography and donor service area).ConclusionThese results suggest that transplantation through the OPTN HOPE variance yields decreases eMWT, perhaps reducing the medium and longer‐term impacts of living with HIV.
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The medium is the message: The geographies of cryptocurrency remittances to Venezuela
Authors: Robins Daniel 
Published: November 2024

AbstractCryptocurrency remittances overcome many regulatory and practical barriers, but there is little empirical research into this increasingly popular remittance medium. In response, this article explores cryptocurrency remittances from Latin America and the Caribbean into Venezuela. Cryptocurrencies as a remittance medium conveys important messages for advocates and critics. To appropriately critique cryptocurrencies, it is important to understand how they are used in the ‘every day’ rather than how their use may be characterised by ideologues. Rather than directly relying on ‘trustless’ and decentralised blockchain technology, ‘really existing’ cryptocurrency remittances are highly intermediated. Access to this medium is often hierarchical, stemming from knowledge barriers but also legal status (and by extension, economic status). The ‘need’ for trusted intermediaries prompts discussions around the relationship between ‘trustless’ blockchain technology and cryptocurrency remittances. This article shows that stablecoins (cryptocurrencies pegged to fiat currencies—usually the US dollar) are the most popular cryptocurrency remittance medium. Stablecoins challenge institutional attempts to geographically restrict currencies, yet also contribute to global processes of dollarisation. This is important to understanding how stablecoins simultaneously undermine spatial barriers to financial access yet may create new ones in the process.