bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term mortality trends among individuals with tuberculosis: a retrospective cohort study of individuals diagnosed with tuberculosis in Brazil
Authors: Kim Sun , Pelissari Daniele M. , Harada Luiza O. , Sanchez Mauro , Oliveira Patricia Bartholomay , Johansen Fernanda D. C. , Maciel Ethel L. N. , Cohen Ted , Castro Marcia C. , Menzies Nicolas A. 
Published: November 2024

AbstractBackgroundEven after successful treatment, tuberculosis (TB) survivors experience elevated morbidity and mortality. However, there is limited evidence on how these risks vary over time and according to individual characteristics.MethodsWe conducted a retrospective cohort study of individuals diagnosed with TB in Brazil, using national TB notifications and linked mortality records for 2007-2016. For this study population we estimated mortality rate ratios (MRRs) and cumulative mortality by year since TB diagnosis, as compared to general population mortality rates matched on age, sex, year, and state. We identified clinical and sociodemographic factors associated with elevated post-TB mortality, and compared the distribution of causes of death to the general population.FindingsThe study sample included 834,594 individuals, with 4.1 million person-years of follow-up. The TB cohort had elevated mortality compared to the general population, particularly in the first year post-diagnosis (MRR 11.28, 95%CI: 11.18–11.37). Post-TB MRRs declined from 3.59 (3.53–3.64) in year 2 to 1.46 (1.34–1.59) in year 10. Cumulative excess mortality was 6.12% (95%CI: 6.07–6.17) after 1 year and 9.90% (9.58–10.24) after 10 years. MRRs were highest for individuals 30-44 years-old at diagnosis. Relapse, loss to follow-up, and co-prevalent conditions like HIV and alcoholism were strongly associated with higher MRRs. Over time, causes of death shifted from TB and HIV to chronic conditions like cardiovascular disease and cancer.InterpretationIndividuals developing TB disease face elevated mortality up to 10 years after diagnosis. These excess risks vary across demographic and clinical characteristics.FundingNIH.
Comamonas aquaticainhibits TIR-1/SARM1 induced axon degeneration
Authors: O’Connor Lauren C , Kang Woo Kyu , Vo Paula , Spinelli Jessica B , Alkema Mark J , Byrne Alexandra B 
Published: November 2024

SummaryEmerging evidence suggests the microbiome critically influences the onset and progression of neurodegenerative diseases; however, the identity of neuroprotective bacteria and the molecular mechanisms that respond within the host remain largely unknown. We took advantage ofCaenorhabditis elegans’well characterized nervous system and ability to eat uni-bacterial diets to determine how metabolites and neuroprotective molecules from single species of bacteria suppress degeneration of motor neurons. We foundComamonas aquaticasignificantly protects against degeneration induced by overexpressing a key regulator of axon degeneration, TIR-1/SARM1. Genetic analyses and metabolomics revealComamonasprotects against neurodegeneration by providing sufficient Vitamin B12 to activate METR-1/MTR methionine synthase in the intestine, which then lowers toxic levels of homocysteine in TIR-1-expressing animals. Defining a molecular pathway betweenComamonasand neurodegeneration adds significantly to our understanding of gut-brain interactions and, given the prominent role of homocysteine in neurodegenerative disorders, reveals how such a bacterium could protect against disease.
Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathy
Authors: Carter Ryan D. , Purnama Ujang , Castro-Guarda Marcos , Montes-Aparicio Claudia N. , Chandran Anandhakumar , Mbasu Richard , Ruby Maxwell , Daly Charlotte , Buffa Francesca M. , Heather Lisa C. , Carr Carolyn A. 
Published: November 2024

AbstractIn type II diabetes (T2DM), the heart is exposed to hyperglycaemia, hyperlipidaemia, and hyperinsulinaemia, leading to insulin resistance and metabolic dysfunction, culminating in diabetic cardiomyopathy (DbCM). Human-centric models of DbCM are needed to provide mechanistic insights and therapeutic targets in a translationally relevant setting. We hypothesised that culturing human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in an “insulin resistance” (IR) media, and assessing this using a systems biology approach, would offer a comprehensive evaluation of dysregulated pathways, establishing their suitability as a model of DbCM.Culturing hiPSC-CMs in 2D or 3D as engineered heart tissue (EHT) in IR media induced insulin resistance and activated numerous pathways implicated in DbCM, including metabolic remodelling, mitochondrial dysfunction, extracellular matrix remodelling, and endoplasmic reticulum stress. Pathways involved in fatty acid oxidation were upregulated, while those involved in glucose metabolism were downregulated, which was validated using radioisotope flux measurements. Adaptation to hypoxia, a key component of post-ischaemic remodelling, was blunted in the 2D IR hiPSC-CMs. Combining proteomic and transcriptomic analyses in the IR 3D EHT revealed significant enrichment of DbCM pathways, with subnetworks enriched for several metabolic and diabetes-related pathways. Additionally, IR 3D EHT displayed impaired relaxation, mimicking the diastolic dysfunction observed in T2DM patients.In conclusion, culturing hiPSC-CM in 2D or 3D in an IR media activates multiple mechanisms implicated in the development of DbCM, with IR 3D EHT also recapitulating the diastolic dysfunction present in patients with T2DM.
Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins
Authors: Bertram Nils , Izawa Toshiaki , Thoma Felix , Schwenkert Serena , Wagener Nikola , Osman Christof , Neupert Walter , Mokranjac Dejana 
Published: November 2024

SummaryRibosome-associated quality control (RQC) protects cells against toxic effects of faulty polypeptides produced by stalled ribosomes. However, mitochondria are vulnerable to C-terminal alanyl-and-threonyl (CAT)-tailed proteins that are generated in this process and faulty nuclear-encoded mitochondrial proteins are handled by the recently discovered mitoRQC. Here, we performed a genome-wide screen in yeast to identify additional proteins involved in mitoRQC. We found that Pth2, a peptidyl-tRNA hydrolase in the mitochondrial outer membrane, influences aggregation of CAT-tailed proteins without majorly affecting the CAT-tailing process itself. Peptidyl-tRNA hydrolase activity is essential during this process, yet the activity of Pth2 can be substituted by another peptidyl-tRNA hydrolase, upon proper localization. Our data suggest that Pth2 acts through modulating protein translocation and that mitochondrial proteostasis network is relieved through increased access of CAT-tailed proteins to cytosolic chaperones. Other hits obtained in the screen show that, in general, delayed protein translocation protects mitochondria against toxic CAT-tailed proteins.
Visuoinertial and visual feedback in online steering control
Authors: Liu Jo-Yu , Cooke James R.H. , Selen Luc J.P. , Medendorp W. Pieter 
Published: November 2024

AbstractMultisensory integration has primarily been studied in static environments, where optimal integration relies on the precision of the respective sensory modalities. However, in numerous situations, sensory information is dynamic and changes over time, due to changes in our bodily state and the surrounding environment. Given that different sensory modalities have different delays, this suggests that optimal integration may not solely depend on sensory precision but may also be affected by the delays associated with each sensory system. To investigate this hypothesis, participants (n = 22, 16 female) engaged in a continuous steering task. Participants sat on a motion platform facing a screen that displayed a cartoonish traffic scene, featuring a car traveling along a road. In the visuoinertial condition, where vestibular and somatosensory feedback were available, they were tasked with counteracting an external multi-frequency perturbation signal, which laterally perturbed the platform and the car, such that the car was kept within the center of the road. In the visual condition, the visual car was perturbed, while the motion platform remained stationary. We show that participants compensate better for the perturbation in the visuoinertial than the visual condition, particularly in the high frequency range of the perturbation. Using computational modelling, we demonstrate that this enhanced performance is partially due to the shorter delay of the vestibular modality. In this condition, participants rely more on the vestibular information, which is less delayed than the more precise but longer delayed, visual information.Author summaryNavigating the world effectively requires the continuous integration of sensory information related to our self-motion, forming a cohesive representation of our current location and direction. Although studies on multisensory integration indicate that sensory inputs are combined optimally based on their precision, these findings have largely been derived from static experimental settings. In real-life situations, the sensory environment changes continuously, as does the state of our body. In such scenarios, how are sensory inputs combined? We developed an experimental paradigm where participants were tasked with controlling a simple vehicle while counteracting a time-varying perturbation signal. To assess the role of different sensory inputs we manipulated whether visual and inertial (primarily vestibular) cues were available or solely visual cues. Our results show that the presence of both visual and inertial cues significantly improved task performance. Modeling suggests this improvement is likely due to the shorter delay associated with the vestibular system compared to the visual system. Collectively, our results suggest that sensory precision alone is insufficient for effective state estimation and control in naturalistic scenarios, where accounting for the different delays of the sensory systems is critical for optimal task performance.
Strategic resource amalgamation and diversified business operations: unraveling competitive advantage in Chinese construction contractors
Authors: Wang Zhixiu , Feng Li 
Published: November 2024

PurposeExisting research lacks exploration of factors that can drive contractors to expand their market, resulting in a research gap where they cannot identify key determining factors in expanding their market. This study aims to explore the multiple pathways of driving diversified business operations of international construction contractors.Design/methodology/approachThis study identified key factors that affect the diversified business operations of international construction contractors and explored the multiple causal paths of factors through Chinese contractors selected from the Engineering News Record top 250 as samples using Fuzzy set qualitative comparative analysis.FindingsThis study reveals that six factors, namely, enterprise scale, operation capability, financial capability, innovation capability, internationalization and corporate social responsibility (CSR), are key drivers of international contractors’ diversified operations. These factors combine to generate four different diversification paths, including three broad diversification paths and one narrow diversification path. The elements involved in these paths have complementary and enhanced roles in broadening the contractor’s diversified business operations, suggesting that contractors may need to integrate resources and make strategic adjustments to enhance their positioning in the international market. Among them, operation capability is the core element of diversified business operations and innovation capability and CSR are also important factors in successfully forming a “broad” diversified operation in the international market.Practical implicationsThe research results provide a profound understanding of which the key determining factors of the diversified business operations of international construction contractors to build new competitive advantages.Originality/valueThis study has enriched the research perspective of contractor competitive advantage theory by introducing the concept of diversified operations, providing a comprehensive theoretical framework for understanding how contractors can expand their market paths.
Mental well­being and work-related quality of life across European workers: characteristics and associated factors
Authors: Erro-Garcés Amaya , Iriarte Redín Concha 
Published: November 2024

Purpose
Mental well-being of employees has decreased as a result of the COVID-19 pandemic. Based on the data collected by Eurofound in the electronic survey “Living, working and COVID-19” (2020), this paper aims to identify which aspects of the work-related quality of life and other sociodemographic variables can explain the mental well-being of workers in, especially, convulsive times like those experienced during COVID-19 and beyond. The main objective is to improve labor welfare in the future.

Design/methodology/approach
With a sample of 8,777 observations (Round 2), cross-sectional analyses were conducted.

Findings
The results indicated that all factors of work quality of life such as working conditions, work–family interface, job stress and job satisfaction were predictors of the mental well-being of workers. Likewise, being a woman, being of mature age, having a partner and having good training/education were variables also associated with mental well-being.

Originality/value
The research revealed that the pandemic in Europe had a greater impact on the psychological well-being of women compared to men. Also, younger populations exhibited decreased levels of mental health.
Unlocking the nexus: intellectual capital and environmental innovations among manufacturing firms in Uganda
Authors: Alinda Kassim , Wakibi Aziz , Ahimbisibwe Godwin Mwesigye , Andabati David 
Published: November 2024

PurposeThis study aims to investigate the intricate relationship between intellectual capital and environmental innovations among manufacturing medium and large firms in Uganda, utilizing the SmartPLS methodology.Design/methodology/approachThis research adopts a cross-sectional and quantitative approach, collecting data through a questionnaire survey from a sample of manufacturing medium and large (ML) firms in Uganda. The collected data underwent analysis to identify patterns and relationships using the SmartPLS structural equation modeling (SEM) technique.FindingsThe findings highlight a distinct pattern: structural capital is the strongest predictor of environmental innovations, with human capital being the next most significant factor. However, the positive relationship with relational capital did not attain statistical significance, suggesting the need for further exploration into inter-firm relationships.Practical implicationsFor managers, investing in robust organizational structures and human capital development programs can enhance firms’ capacity to drive eco-friendly initiatives, aligning with global sustainability agendas. Policymakers are encouraged to create an enabling environment that nurtures IC and incentivizes environmental innovation through supportive policies such as tax incentives and funding mechanisms for green technologies.Originality/valueThis study enriches the intellectual discourse on IC and environmental innovation by employing SmartPLS methodology to highlight the nuanced impact of its components, emphasizing the multifaceted nature of IC and its role in driving EI.
From adaptation to transformation: how to stimulate leaders’ change-oriented organizational citizenship behaviors in project-based temporary organizations
Authors: Liu Xinhua , Guo Peng , Zhao Jing 
Published: November 2024

PurposeProject-based temporary organizations, as an efficient organizational form for the execution of complex and innovative tasks, encounter challenges in fostering the effectiveness of inter-organizational cooperation within their temporary, uncertain, and dynamic nature. Although change-oriented organizational citizenship behaviors are recognized for promoting organizational relationships and performance in changing contexts, research in temporary organizational settings remains sparse. This study diverges from the majority concentrating on change-oriented behaviors on intra-organizational leader-employee relations and behaviors, aiming to propose a dynamic adaptive capacity of organizational leaders and explore how leadership capabilities and organizational climate shape their change-oriented organizational citizenship behaviors at inter-organizational level.Design/methodology/approachDeveloping a person-organization fit model tailored for complex and dynamic organizational settings, using survey data from 225 leaders with project cooperative experience and structural equation modeling for empirical analysis.FindingsThis study reveals the direct positive influences of organizational leaders’ dynamic adaptive capacity on their changed-oriented organizational citizenship behaviors. And, change self-efficacy, as a mediating psychological trait, enhances the positive relation between dynamic adaptive capacity and changed-oriented organizational citizenship behaviors. The findings also highlight person-organization interactions, where organizational justice, acting as a situational and moderating factor, has a positive yet disruptive effect on the relationship between dynamic adaptive capacity, change self-efficacy, and changed-oriented organizational citizenship behaviors.Originality/valueThis research enriches the mechanisms linking dynamic managerial capability in organizational leadership to citizenship behaviors at the micro-level, providing valuable insights for the management and development of temporary cross-organizational cooperation.
Motivating cybersecurity behaviors: a beyond reasoned action conceptualization
Authors: Hinsz Verlin B. 
Published: November 2024

PurposeA critical issue in organizations concerned with cybersecurity is how to motivate personnel to engage in safety and security behaviors to counter potential threats. For these organizations to be effective, they must rely upon their members who are motivated to engage in behaviors to assure various forms of cybersecurity.Design/methodology/approachA conceptualization is described outlining the factors and processes involved in motivating cybersecurity behaviors. The theoretical starting point is the reasoned action approach (Fishbein and Ajzen, 2010), which provides a strong and parsimonious basis for considering the processes and factors that predict safety and security behaviors (intentions, perceived behavioral control, subjective norms, attitude toward the behavior and beliefs).FindingsThe conceptualization presented goes beyond the reasoned action approach to consider factors involved in cybersecurity behaviors that might not be reasoned (work routines and habits and motivating emotions). This more integrated conceptualization describes how personal factors such as anticipated affect, attitude toward the process and personal norms can be seen as contributing to motivated behavior.Originality/valueThe beyond reasoned action conceptualization is of value to organizations for which motivated safety and security behaviors contribute to their effectiveness, with the conceptualization providing practical recommendations for enhancing cyber safety and cybersecurity. A research agenda based on this beyond reasoned action conceptualization articulates numerous avenues for further investigation.
Understanding inter organizational learning for improvement in integrated health care – a Norwegian case study about collaboration across borders
Authors: Lørum Rachel M. , Skyvulstad Hilde , Eri-Montsma Astrid , Smith Frida 
Published: November 2024

Purpose
The purpose of this study was to explore important elements involved in interorganizational learning (IOL) in the complex context of integrated health care.

Design/methodology/approach
The study applied concept-driven content analysis of qualitative data collected from documents, protocols, reports, reflection circles and interviews related to an improvement initiative in Norwegian integrated health care for elderly and fragile patients.

Findings
The analysis supports the applicability of Engeström’s activity system model to better understand the local contexts of IOL in integrated health care. However, the study also identified an essential additional contextual element in the case under study: an organizational network structure binding all involved parties together. This structure was crucial for facilitating the IOL process, indicating potential for further development of Engeström’s model to address the complexities of integrated health care.

Originality/value
This study tested and extended a long-standing model – the human activity system – within the context of integrated health care. The authors propose introducing leadership as a distinct element, organized as a network structure that connects all stakeholders. Implications for leaders and policymakers include the importance of developing network structures and conducting contextual analysis before designing IOL processes in integrated health care. The study opens new avenues for research on IOL in integrated health care.
The causes of perceived government trustworthiness
Authors: DEVINE DANIEL , VALGARÐSSON VIKTOR , JENNINGS WILL , STOKER GERRY , BUNTING HANNAH 
Published: November 2024

AbstractThis paper examines the qualities of governments that influence their perceived trustworthiness, presenting the first experimental study of the distinct roles of ‘competence’, ‘benevolence’ and ‘integrity’ (CBI) in shaping trust in government. We empirically test the effects of these three dimensions of trustworthiness through conjoint experiments conducted in five countries: Britain, Croatia, Spain, Argentina and France. The results indicate that benevolence – government acting in citizens' interests – is the most significant determinant of trust judgements across individuals and nations. Competence and integrity have a secondary, approximately equal effect. Building on recent advances in analyses of conjoint experiments, we explore how these attributes are conditional on each other, and how respondent characteristics moderate those effects. The findings reveal that the effects of attributes are generally consistent, although respondent left‐right ideology moderates the impact of government competence.