bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arte, tragédia e interdição da criticidade: O confronto entre ética e estética em "Estão apenas ensaiando", de Bernardo Carvalho
Authors: Silva Márcio Felipe da , Pereira Vinícius Carvalho 
Published: December 2018

Em certas circunstâncias, tomar a escrita de ficção como uma dimensão outra do real parece equivaler à suposição de que a maravilha de um truque de mágica está não na engenhosidade técnica através da qual nossos sentidos são ludibriados, mas na ideia de que, por um instante, as leis da física foram de fato suspensas e uma pessoa levitou ou dois corpos ocuparam o mesmo lugar a um só tempo. À luz das considerações de Ortega y Gasset sobre a autonomia do objeto artístico em relação à realidade da qual, ao tratar da arte, o público em geral não consegue prescindir, o conto “Estão apenas ensaiando”, de Bernardo Carvalho, revela-se – tanto por seu conteúdo quanto por sua expressão – pródigo em possibilidades e leitura que ressaltam o embate entre ética e estética. Assim, o raciocínio alegórico de Gasset e os questionamentos ético-narrativos presentes em textos de Adorno e de Brecht são aplicados, nesta análise do conto de Carvalho, a fim de evidenciar como a ordem cronológica entre o evento catastrófico e o objeto artístico que com ele guarde alguma semelhança tem pouca importância no modo como a interdição do discurso estético se opera.
The birds of Kurdistan Province, western Iran
Authors: Zarei Fatah , Hosseini Seyed Naseh , Hussein Ridha Hassan , Pezeshk Jalal , Rahim Mariwan , Maleki Loghman 
Published: December 2018

A checklist of the birds of Kurdistan Province, western Iran, is presented based on records of avian species whose presence was confirmed in the area as a result of field surveys conducted from 2010 to 2018, literature review, and personal communications from researchers. This edition of the checklist includes 310 species of 23 orders and 59 families. Accepted English names, scientific names, authority, remarks on taxonomy, status, habitat, vernacular names in Kurdish, and conservation status pertaining to the birds of this region are given. Our work comprises the first ornithological document to cover all the bird species recorded to date in this province.
Cardiac Troponin I and Risk of Cardiac Events in Patients With Heart Failure and Preserved Ejection Fraction
Authors: Myhre Peder L. , O’Meara Eileen , Claggett Brian L. , de Denus Simon , Jarolim Petr , Anand Inder S. , Beldhuis Iris E. , Fleg Jerome L. , Lewis Eldrin , Pitt Bertram , Rouleau Jean L. , Solomon Scott D. , Pfeffer Marc A. , Desai Akshay S. 
Published: December 2018

Background:
Levels of cTn (cardiac troponin) are frequently elevated in patients with heart failure (HF) and reduced ejection fraction (EF) and correlate with the risk for mortality. However, factors associated with high cTn concentrations and the association with cardiovascular events in patients with HF and preserved EF are unclear.

Methods and Results:

Of 1767 subjects with symptomatic HF with preserved EF from the Americas part of the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial), 236 underwent baseline measurements of high-sensitivity (hs) cTnI using the Abbott Architect STAT assay. Baseline factors correlated with hs-cTnI levels were assessed in stepwise linear regression models and the association between hs-cTnI and adjudicated study outcomes was examined in Cox models. The median hs-cTnI concentration at baseline was 6.3 ng/L (interquartile range, 3.4–12.9 ng/L) with levels detectable in 99.2% of patients. Higher hs-cTnI concentrations were associated with male sex, black race, lower estimated glomerular filtration rate and higher NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. After multivariable adjustment, higher concentrations of hs-cTnI were associated with greater risk for the composite of cardiovascular death or HF hospitalization (69 events during mean follow-up 2.6±1.5 years): hazard ratio 1.42 (95% CI, 1.20–1.69),
P
<0.001 per doubling of hs-cTnI. Compared with those in the lowest quartile of hs-cTnI, patients in the highest quartile demonstrated a nearly 5-fold higher risk of cardiovascular death and HF hospitalization (hazard ratio 4.85 [1.99–11.83],
P
=0.001). There was no interaction between hs-cTnI and spironolactone treatment with regard to the primary composite end point (interaction
P
=0.94).

Conclusions:
In ambulatory patients with HF with preserved EF, levels of hs-cTnI are higher in male patients with black race, lower estimated glomerular filtration rate, and higher NT-proBNP. As in those with HF and reduced EF, higher hs-cTnI levels are independently associated with risk for cardiovascular death and HF hospitalization.

CLINICAL TRIAL REGISTRATION:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00094302.
The Ross Procedure: A Systematic Review, Meta-Analysis, and Microsimulation
Authors: Etnel Jonathan R.G. , Grashuis Pepijn , Huygens Simone A. , Pekbay Begüm , Papageorgiou Grigorios , Helbing Willem A. , Roos-Hesselink Jolien W. , Bogers Ad J.J.C. , Mokhles M. Mostafa , Takkenberg Johanna J.M. 
Published: December 2018

Background:
To support decision-making in aortic valve replacement in children and adults, we provide a comprehensive overview of outcome after the Ross procedure.

Methods and Results:
A systematic search was conducted for publications reporting clinical outcome after the Ross procedure, published between January 1, 2000, and November 22, 2017. Reported event rates and time-to-event data were pooled and entered into a microsimulation model to calculate life expectancy and lifetime event risk. Ninety-nine publications were included (13 129 patients; total follow-up: 93 408 patient-years, pooled mean follow-up: 7.9±5.3 years). Pooled mean age at surgery was 9.4±5.5 years for children and 41.9±11.4 for adults. For children and adults, respectively, pooled early mortality risk was 4.19% (95% CI, 3.21–5.46) and 2.01% (95% CI, 1.44–2.82), late mortality rate was 0.54%/y (95% CI, 0.42–0.70) and 0.59%/y (95% CI, 0.46–0.76), autograft reintervention 1.28%/y (95% CI, 0.99–1.66) and 0.83%/y (95% CI, 0.68–1.01), and right ventricular outflow tract reintervention 1.97%/y (95% CI, 1.64–2.36) and 0.47%/y (95% CI, 0.37–0.59). Pooled thromboembolism and bleeding rates were low and comparable to the general population. Lifetime risks of autograft and right ventricular outflow tract reintervention were, respectively, 94% and 100% for children and 49% and 19% for a 45-year-old. Estimated life expectancy after surgery was 59 years for children (general population: 64 years) and 30 years for a 45 years old (general population: 31 years).

Conclusions:
Through excellent survival and avoidance of the burden of anticoagulation, the Ross procedure provides a unique opportunity for patients whose preferences do not align with the outcome provided by mechanical valve replacement and for growing children who also benefit from autograft diameter increase along with somatic growth. On the downside, almost all pediatric and many adult Ross patients will require a reintervention in their lifetime.
Dynamically Downscaled Climate Simulations of the Indian Monsoon in the Instrumental Era: Physics Parameterization Impacts and Precipitation Extremes
Authors: Huo Yiling , Peltier W. Richard 
Published: December 2018

AbstractThe complex orography of South Asia, including both the Himalayas and the Tibetan Plateau, renders the regional climate complex. How this climate, especially the monsoon circulations, will respond to the global warming process is important given the large population of the region. In a first step toward a contribution to the understanding of the expected impacts, a series of dynamically downscaled instrumental-era climate simulations for the Indian subcontinent are described and will serve as a basis for comparison against global warming simulations. Global simulations based upon the Community Earth System Model (CESM) are employed to drive a dynamical downscaling pipeline in which the Weather Research and Forecasting (WRF) Model is employed as regional climate model, in a nested configuration with two domains at 30- and 10-km resolution, respectively. The entire ensemble was integrated for 15 years (1980–94), with the global model representing a complete integration from the onset of Northern Hemisphere industrialization. Compared to CESM, WRF significantly improves the representation of orographic precipitation. Precipitation extremes are also characterized using extreme value analysis. To investigate the sensitivity of the South Asian summer monsoon simulation to different parameterization schemes, a small physics ensemble is employed. The Noah multiphysics (Noah-MP) land surface scheme reduces the summer warm bias compared to the Noah land surface scheme. Compared with the Kain–Fritsch cumulus scheme, the Grell-3 scheme produces an increased moisture bias at the first western rain barrier, whereas the Tiedtke scheme produces less precipitation over the subcontinent than observed. Otherwise the improvement of fit to the observations derived from applying the downscaling methodology is highly significant.
Association between nonmedical use of opioids or sedatives and suicidal behavior among Chinese adolescents: An analysis of sex differences
Authors: Guo Lan , Luo Min , Wang Wanxin , Xiao Di , Xi Chuhao , Wang Tian , Zhao Meijun , Zhang Wei-Hong , Lu Ciyong 
Published: December 2018

Objective: The rising rate of suicidal behavior among adolescents is a growing concern, and sex differences may induce differential exposure to prescription drug misuse or suicidal behavior. We estimated, among Chinese adolescents, (1) the prevalence of nonmedical use of prescription drugs, suicidal ideation and suicide attempts; (2) whether nonmedical use of prescription drugs was independently associated with suicidal ideation and suicide attempts; and (3) whether there were sex differences in the associations. Methods: This was a secondary analysis of the data drawn from the 2015 National School-based Chinese Adolescents Health Survey. A total of 94,911 students completed questionnaires and qualified for our survey (response rate: 93.7%). All analyses were conducted separately for boys and girls. Results: There were significant sex differences in the prevalence of opioid or sedative misuse, and the sources and reasons for nonmedical use of prescription drugs ( p < 0.05). The prevalence of suicidal ideation or suicide attempts was significantly higher in girls than in boys (suicidal ideation: 17.9% among girls vs 14.1% among boys; suicide attempts: 3.5% among girls vs 2.7% among boys). Among girls, frequent use of opioids was associated with an increased risk of suicidal ideation (adjusted odds ratio = 1.84, 95% confidence interval = [1.57, 2.17]) and suicide attempts (adjusted odds ratio = 2.96, 95% confidence interval = [2.34, 3.74]), and frequent use of sedatives was also positively associated with suicidal ideation (adjusted odds ratio = 2.23, 95% confidence interval = [1.91, 2.60]) and suicide attempts (adjusted odds ratio = 4.02, 95% confidence interval = [3.25, 4.99]). These associations were also statistically significant in boys, but the magnitudes of adjusted odds ratios for the associations between frequent use of opioids and sedatives and suicidal behavior were greater in girls than boys. Conclusion: There exist significant sex differences in the prevalence rates of nonmedical use of prescription drugs and suicidal behavior, and the child’s sex plays a role in the association between nonmedical use of prescription drugs and suicidal behavior. The significant sex differences found above may provide a basis for early identification of adolescents at high risk of suicidal behavior.
Families and friends group: a group that straddles teaching, support and transformation
Authors: Radcliffe Michelle , Cilasun Jale 
Published: December 2018

This article describes the structure, process and evaluation of a families and friends group in a personality disorder treatment service for people experiencing Borderline Personality Disorder using a Mentalization Based Therapy model. We highlight the benefits of working with family members and consider the differences between psycho-education, support groups and group-analytical approaches. Inclusion of families in recovery is well argued. Providing support and education for family members can improve communication and reduce burden in families. In the treatment of patients with Borderline Personality Disorder, the focus often remains upon meeting patients’ needs and not of those who support them. We used a formal evaluation of the effectiveness of the families and friends group in the areas of learning and support. Qualitative questions were used to gain more in depth information regarding the impact of the group. Our results support the approach of working with the family rather than only focusing on the individual. There was an improvement in the communication leading to positive change in relationships between family members and their loved ones. This takes place despite the group being a once a month and drop-in. However, as this was evaluation of one service, more research in this area is needed.
The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy
Authors: Bilich Tatjana , Nelde Annika , Bichmann Leon , Roerden Malte , Salih Helmut R. , Kowalewski Daniel J. , Schuster Heiko , Tsou Chih-Chiang , Marcu Ana , Neidert Marian C. , Lübke Maren , Rieth Jonas , Schemionek Mirle , Brümmendorf Tim H. , Vucinic Vladan , Niederwieser Dietger , Bauer Jens , Märklin Melanie , Peper Janet K. , Klein Reinhild , Kohlbacher Oliver , Kanz Lothar , Rammensee Hans-Georg , Stevanović Stefan , Walz Juliane S. 
Published: December 2018

Abstract
Antileukemia immunity plays an important role in disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Thus, antigen-specific immunotherapy holds promise for strengthening immune control in CML but requires the identification of CML-associated targets. In this study, we used a mass spectrometry–based approach to identify naturally presented HLA class I– and class II–restricted peptides in primary CML samples. Comparative HLA ligandome profiling using a comprehensive dataset of different hematological benign specimens and samples from CML patients in deep molecular remission delineated a panel of novel frequently presented CML-exclusive peptides. These nonmutated target antigens are of particular relevance because our extensive data-mining approach suggests the absence of naturally presented BCR-ABL– and ABL-BCR–derived HLA-restricted peptides and the lack of frequent tumor-exclusive presentation of known cancer/testis and leukemia-associated antigens. Functional characterization revealed spontaneous T-cell responses against the newly identified CML-associated peptides in CML patient samples and their ability to induce multifunctional and cytotoxic antigen-specific T cells de novo in samples from healthy volunteers and CML patients. Thus, these antigens are prime candidates for T-cell–based immunotherapeutic approaches that may prolong TKI-free survival and even mediate cure of CML patients.
Quality Improvement Training in a Variety of Cancer Care Delivery Settings: Experiences From a Comprehensive Cancer Center, an Academic Medical Center, and Community Practices
Authors: Zerillo Jessica A. , Carballo Victoria , Tremonti Carole K. , Kalibatas Orinta , Cummings Brian M. , Jacobson Joseph O. 
Published: December 2018

Purpose: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions. Methods: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months. The curriculum included didactic training sessions that attendees applied to their local project-based work and that required plan-do-study-act cycles. The curriculum was adapted to the smaller practice setting through use of a workbook and a reduced focus on quantitative methods. All teams were supported by coaches and provided final presentations to leadership. The self-rated abilities of trainees to use 15 QI tools were assessed with a pre/post training survey that had five response categories (information, skill, knowledge, understanding, and wisdom). Local institutional and external project presentations were tracked. Results: During 7 years, 129 trainees participated in 56 QI projects. All of the 15 QI tools had 80% of trainees rate themselves in the top three categories (knowledge, understanding, and wisdom) after the training; none met this threshold before. Multiple projects were presented in institutional and external settings. Most projects targeted three of the four domains of the ASCO Quality Oncology Practice Initiative certification program standards. Conclusions: We implemented and sustained QI training programs in a variety of cancer delivery settings. The flexible training model should be easily adoptable by others.
Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells
Authors: Hobeika Elie , Armouti Marah , Kala Hamsini , Fierro Michele A , Winston Nicola J , Scoccia Bert , Zamah Alberuni M , Stocco Carlos 
Published: December 2018

Abstract

Context
The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.

Objective
Determine GDF9 and BMP15 effects on FSH stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression.

Design
Primary human cumulus GCs in culture.

Setting
University infertility center.

Patients or Other Participants
GCs of 60 women undergoing in vitro fertilization were collected.

Interventions
Cells were treated with GDF9 and/or BMP15 (GB) in the presence or absence of FSH, dibutyryl cAMP, or SMAD inhibitors.

Main Outcome Measures
Promoter activity, mRNA, protein, and estradiol levels were quantified.

Results
FSH and GB treatment increased CYP19A1 promoter activity, mRNA, and protein levels as well as estradiol when compared with cells treated with FSH only. GB treatment potentiated cAMP stimulation of aromatase and IGF2 stimulation by FSH. GB effects were inhibited by SMAD3 inhibitors and IGF1 receptor inhibitors. GB, but not FSH, stimulates SMAD3 phosphorylation.

Conclusion
The combination of GDF9 and BMP15 potently stimulates the effect of FSH and cAMP on CYP19a1 promoter activity and mRNA/protein levels. These effects translate into an increase in estradiol production. This potentiation seems to occur through activation of the SMAD2/3 and SMAD3 signaling pathway and involves, at least in part, the effect of the IGF system.
The principles of tomorrow's university
Authors: Katz Daniel S. , Allen Gabrielle , Barba Lorena A. , Berg Devin R. , Bik Holly , Boettiger Carl , Borgman Christine L. , Brown C. Titus , Buck Stuart , Burd Randy , de Waard Anita , Eve Martin Paul , Granger Brian E. , Greenberg Josh , Howe Adina , Howe Bill , Khanna May , Killeen Timothy L. , Mayernik Matthew , McKiernan Erin , Mentzel Chris , Merchant Nirav , Niemeyer Kyle E. , Noren Laura , Nusser Sarah M. , Reed Daniel A. , Seidel Edward , Smith MacKenzie , Spies Jeffrey R. , Turk Matt , Van Horn John D. , Walsh Jay 
Published: December 2018

In the 21st Century, research is increasingly data- and computation-driven. Researchers, funders, and the larger community today emphasize the traits of openness and reproducibility. In March 2017, 13 mostly early-career research leaders who are building their careers around these traits came together with ten university leaders (presidents, vice presidents, and vice provosts), representatives from four funding agencies, and eleven organizers and other stakeholders in an NIH- and NSF-funded one-day, invitation-only workshop titled "Imagining Tomorrow's University." Workshop attendees were charged with launching a new dialog around open research – the current status, opportunities for advancement, and challenges that limit sharing. The workshop examined how the internet-enabled research world has changed, and how universities need to change to adapt commensurately, aiming to understand how universities can and should make themselves competitive and attract the best students, staff, and faculty in this new world. During the workshop, the participants re-imagined scholarship, education, and institutions for an open, networked era, to uncover new opportunities for universities to create value and serve society. They expressed the results of these deliberations as a set of 22 principles of tomorrow's university across six areas: credit and attribution, communities, outreach and engagement, education, preservation and reproducibility, and technologies. Activities that follow on from workshop results take one of three forms. First, since the workshop, a number of workshop authors have further developed and published their white papers to make their reflections and recommendations more concrete. These authors are also conducting efforts to implement these ideas, and to make changes in the university system. Second, we plan to organise a follow-up workshop that focuses on how these principles could be implemented. Third, we believe that the outcomes of this workshop support and are connected with recent theoretical work on the position and future of open knowledge institutions.