bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELASI INTERPERSONAL DALAM PSIKOLOGI KOMUNIKASI
Authors: Wulandari Rustini , Rahmi Amelia 
Published: February 2019

<p><em>Survival of human life is proof that human being able to solve and fulfill requirements of life which is individual and also social.</em><em> </em><em>Human life is a building interpersonal relationship with each other, called interpersonal relationship. The more an active person building relationships with others it will build an extensive interpersonal network and produce quality self-competence. This is what can bring success in many ways. Generally humans can adjust to the situation faced by learning the previous experience. Overtime the relationship develops an individual character. The psychological aspect of both parties involved in the relationship are more decesive compared with sociological and cultural aspects. The existence of psychological aspect that determine the process of interpersonal communication has led to a specific study in interpersonal relationships into studies in this article, although the study has not been based on in-depth research.</em></p><p><strong><em>Keywords</em></strong><em>: communication, psychology, interpersonal relation</em><em>ship</em><em></em></p><p>-----------------------------------------------------------------------------------</p><p>Kelangsungan hidup manusia di muka bumi hingga kini merupakan bukti bahwa manusia mampu menyelesaikan dan memenuhi kebutuhan yang bersifat individu dan sekaligus sosial.Kehidupan ini merupakan bangunan relasi antarpersonal satu dengan yang lainnya, disebut relasi interpersonal. Semakin seseorang aktif membangun relasi dengan sesama maka akan terbangun jaringan interpersonal yang luas dan menghasilkan kompetensi diri yang berkualitas. Hal inilah yang dapat membawa kesuksesan dalam banyak hal.</p><p>Umumnya, manusia dapat menyesuaikan dengan situasi yang dihadapi dengan cara mempelajari pengalaman sebelumnya. Seiring dengan waktu hubungan berkembanglah sebuah karakter individu. Aspek-aspek psikologis yang dimiliki kedua belah pihak yang terlibat dalam relasi lebih menentukan dibanding dengan aspek sosiologis dan kultural.Adanya aspek psikologis yang menentukan proses komunikasi interpersonal telah memunculkan kajian spesifik dalam relasi interpersonal menjadi kajian dalam artikel ini, meskipun kajiannya belum berbasis riset secara mendalam</p><p> </p><p><strong>Kata </strong><strong>k</strong><strong>unci</strong>: komunikasi, psikologi, relasi interpersonal.</p>
Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway
Authors: Wang Zeng , Shi Huairui , Zhao Huan , Dong Zhen , Zhao Buchang , Weng Xinyu , Liu Rongle , Li Xiao , Hu Kai , Zou Yunzeng , Sun Aijun , Ge Junbo 
Published: February 2019

Background:
We recently reported that Naoxintong (NXT), a China Food and Drug Administration (FDA)-approved cardiac medicine, could reduce the plaque size, but the underlying mechanism remains elusive now.

Objective:
In this study, we investigated the effects of NXT on foam cell accumulation both in vivo and in vitro and explored related mechanisms.

Method:
THP-1 cells and bone marrow-derived macrophages were incubated with oxidized low-density lipoprotein (ox-LDL) with/without Naoxintong. ApoE-/- mice fed an atherogenic diet were administered to receive NXT for eight weeks. Macrophage-derived foam cell formation in plaques was measured by immunohistochemical staining. Expression of proteins was evaluated by Western blot. Lentivirus was used to knockdown PPARα in THP-1 cells.

Results:
After NXT treatment, foam cell accumulation was significantly reduced in atherosclerotic plaques. Further investigation revealed that oxidized low-density lipoprotein (ox-LDL) uptake was significantly decreased and expression of scavenger receptor class A (SR-A) and class B (SR-B and CD36) was significantly downregulated post-NXT treatment. On the other hand, NXT increased cholesterol efflux and upregulated ATP-binding cassette (ABC) transporters (ABCA-1 and ABCG-1) in macrophages. Above beneficial effects of NXT were partly abolished after lentiviral knockdown of PPARα.

Conclusion:
Our findings suggest that NXT could retard atherosclerosis by inhibiting foam cell formation through reducing ox-LDL uptake and enhancing cholesterol efflux and above beneficial effects are partly mediated through PPARα pathway.
Synthesis of a Fluorescent Whitening Molecule and its Application to Wool Fibres
Authors: Abrar Shazia , Naqvi Kazim Raza , Javed Sadia , Kiran Shumaila , Gulzar Tahsin 
Published: February 2019

Aim and Objective:
Reactive dye molecules are commonly employed to dye or modify colour characteristics
of wool fibres. Yellowness of wool fibres poses a challenge and here, we report synthesis of a reactive
fluorescent molecule and its application to wool fibres to reduce yellowness of the wool fibre and improve
its colour features.

Material and Methods:

The new molecule was based upon 7-amino-4-methylcoumarin (AMC) and 2,4,6-
trichloro-1,3,5-triazine (TZT). The synthesis involved a two-step chemical reaction, initiated by the nucleophilic
substitution of a chloro group on the triazine ring with the hydroxyl group of 4-hydroxybenzenesulfonic
acid. The substitution of 2nd chloro group at triazine ring with the amino group of 7-amino-4-methylcoumarin
resulted in a novel molecule with a monofunctional reactive chloro group (AMC-MCT molecule).

Results:
The new molecule was applied to the wool fibres using exhaust dyeing method. This exhibited a high
exhaustion value; however low fixation and total efficiency values were observed for the new molecule. The
resultant wool fibres exhibited fluorescence which shows that aminocoumarin fluorophore retained its fluorescence
when incorporated in the new molecule. An assessment of the molecule for yellowness index in a controlled
exposure to UV radiation suggested an improvement in whiteness of wool fibre.

Conclusion:
A novel aminocoumarin based fluorescent whitening molecule 2 has been synthesised and applied
to the wool fibres. The new molecule continued to exhibit fluorescence after its application to the wool fibres.
These results will encourage researchers to explore further possibilities for reactive whitening agent for wool
fibres.
Tinea Imbricata: An Overview
Authors: Leung Alexander K.C. , Leong Kin F. , Lam Joseph M. 
Published: February 2019

Background:
Tinea imbricata is a chronic superficial mycosis caused mainly by Trichophyton
concentricum. The condition mainly affects individuals living in primitive and isolated environment
in developing countries and is rarely seen in developed countries. Physicians in
nonendemic areas might not be aware of this fungal infection.

Objective:
To familiarize physicians with the clinical manifestations, diagnosis, and treatment of
tinea imbricata.

Methods:
A PubMed search was completed in Clinical Queries using the key terms "Tinea imbricata"
and "Trichophyton concentricum". The search strategy included meta-analyses, randomized
controlled trials, clinical trials, observational studies, reviews, and case reports. The information
retrieved from the above search was used in the compilation of the present article.A PubMed search was completed in Clinical Queries using the key terms "Tinea imbricata"
and "Trichophyton concentricum". The search strategy included meta-analyses, randomized
controlled trials, clinical trials, observational studies, reviews, and case reports. The information
retrieved from the above search was used in the compilation of the present article.

Results:
The typical initial lesions of tinea imbricata consist of multiple, brownish red, scaly, pruritic
papules. The papules then spread centrifugally to form annular and/or concentric rings that can
extend to form serpinginous or polycyclic plaques with or without erythema. With time, multiple
overlapping lesions develop, and the plaques become lamellar with abundant thick scales adhering
to the interior of the lesion, giving rise to the appearance of overlapping roof tiles, lace, or fish
scales. Lamellar detachment of the scales is common. The diagnosis is mainly clinical, based on the
characteristic skin lesions. If necessary, the diagnosis can be confirmed by potassium hydroxide
wet-mount examination of skin scrapings of the active border of the lesion which typically shows
short septate hyphae, numerous chlamydoconidia, and no arthroconidia. Currently, oral terbinafine
is the drug of choice for the treatment of tinea imbricata. Combined therapy of an oral antifungal
agent with a topical antifungal and keratolytic agent may increase the cure rate.

Conclusion:
In most cases, a spot diagnosis of tinea imbricata can be made based on the characteristic
skin lesions consisting of scaly, concentric annular rings and overlapping plaques that are pruritic.
Due to popularity of international travel, physicians involved in patient care should be aware
of this fungal infection previously restricted to limited geographical areas.
Overview of Computer Aided Detection and Computer Aided Diagnosis Systems for Lung Nodule Detection in Computed Tomography
Authors: Ziyad Shabana Rasheed , Radha Venkatachalam , Vayyapuri Thavavel 
Published: February 2019

Background:
Lung cancer has become a major cause of cancer-related deaths. Detection
of potentially malignant lung nodules is essential for the early diagnosis and clinical management
of lung cancer. In clinical practice, the interpretation of Computed Tomography (CT) images is
challenging for radiologists due to a large number of cases. There is a high rate of false positives in
the manual findings. Computer aided detection system (CAD) and computer aided diagnosis systems
(CADx) enhance the radiologists in accurately delineating the lung nodules.

Objectives:
The objective is to analyze CAD and CADx systems for lung nodule detection. It is
necessary to review the various techniques followed in CAD and CADx systems proposed and implemented
by various research persons. This study aims at analyzing the recent application of various
concepts in computer science to each stage of CAD and CADx.

Methods:
This review paper is special in its own kind because it analyses the various techniques
proposed by different eminent researchers in noise removal, contrast enhancement, thorax removal,
lung segmentation, bone suppression, segmentation of trachea, classification of nodule and nonnodule
and final classification of benign and malignant nodules.

Results:
A comparison of the performance of different techniques implemented by various researchers
for the classification of nodule and non-nodule has been tabulated in the paper.

Conclusion:
The findings of this review paper will definitely prove to be useful to the research
community working on automation of lung nodule detection.
The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages
Authors: Beara Ivana , Majkić Tatjana , Fioravanti Stefania , Trulli Laura , Mimica-Dukić Neda , Pellacani Lucio , Saso Luciano 
Published: February 2019

Background:
A convenient approach to modulation of the inflammation has an influence
on the production of inflammatory mediators – icosanoids, generated in arachidonic acid
(AA) metabolism. The common therapeutic activity of non-steroidal anti-inflammatory drugs
(NSAID), such as aspirin, includes inhibition of two crucial enzymes of AA metabolism - cyclooxygenase-
1 and -2 (COX-1/2), with certain risk for gastrointestinal and renal intolerance. Ever
since the enrolment of COX-2, particularly overabundance of its main products prostaglandin E2
(PGE2) and thromboxane A2 (TXA2) in numerous pathological processes was recognized, it became
a significant therapeutic target.

Objective:
The aim of this study was to examine the effects of synthesized organo-fluorine compounds
on PGE2 and TXA2 production in the inflammation process.

Methods:
Trifluoromethyl compounds were synthesized from N-benzyl trifluoromethyl aldimine,
commercially available 2-methyl or 2-phenyl α-bromo esters (β-lactams trans-1 and trans-2 and
trifluoromethyl β-amino ester, respectively) and methyl 2-isocyanoacetate (2-imidazoline trans-4).
The reactions proceeded with high geometric selectivity, furnishing the desired products in good
yields. The influence of newly synthesized compounds on PGE2 and TXA2 production in human
leukemic U937 macrophages on both enzyme activity and gene expression levels was observed.

Results:
Among the tested trifluoromethyl compounds, methyl trans-1-benzyl-5-(trifluoromethyl)-
4,5-dihydro-1H-imidazole-4-carboxylate (trans-4) can be distinguished as the most powerful antiinflammatory
agent, probably due to its trifluoromethyl-imidazoline moiety.

Conclusion:
Some further structural modifications in tested compounds and particularly in the
synthesis of different trifluoromethyl imidazolines could contribute to the development of new
COX-2 inhibitors and potent anti-inflammatory agents.
Clinical Trial Data Management Software: A Review of the Technical Features
Authors: Nourani Aynaz , Ayatollahi Haleh , Dodaran Masoud Solaymani 
Published: February 2019

Background:Data management is an important, complex and multidimensional process in clinical trials. The execution of this process is very difficult and expensive without the use of information technology. A clinical data management system is software that is vastly used for managing the data generated in clinical trials. The objective of this study was to review the technical features of clinical trial data management systems.Methods:Related articles were identified by searching databases, such as Web of Science, Scopus, Science Direct, ProQuest, Ovid and PubMed. All of the research papers related to clinical data management systems which were published between 2007 and 2017 (n=19) were included in the study.Results:Most of the clinical data management systems were web-based systems developed based on the needs of a specific clinical trial in the shortest possible time. The SQL Server and MySQL databases were used in the development of the systems. These systems did not fully support the process of clinical data management. In addition, most of the systems lacked flexibility and extensibility for system development.Conclusion:It seems that most of the systems used in the research centers were weak in terms of supporting the process of data management and managing clinical trial's workflow. Therefore, more attention should be paid to design a more complete, usable, and high quality data management system for clinical trials. More studies are suggested to identify the features of the successful systems used in clinical trials.
Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin- Thiazole Hybrids as Anticancer Agents
Authors: Goud Nerella S. , Ghouse Mahammad S. , Vishnu Jatoth , Pranay Jakkula , Alvala Ravi , Talla Venu , Qureshi Insaf A. , Alvala Mallika 
Published: February 2019

Background:
Human Galectin-1, a protein of lectin family showing affinity towards β-galactosides
has emerged as a critical regulator of tumor progression and metastasis, by modulating diverse biological events
including homotypic cell aggregation, migration, apoptosis, angiogenesis and immune escape. Therefore,
galectin-1 inhibitors might represent novel therapeutic agents for cancer.

Methods:
A new series of heterocyclic imines linked coumarin-thiazole hybrids (6a-6r) was synthesized and
evaluated for its cytotoxic potential against a panel of six human cancer cell lines namely, lung (A549), prostate
(DU-145), breast (MCF-7 & MDA-MB-231), colon (HCT-15 & HT-29) using MTT assay. Characteristic apoptotic
assays like DAPI staining, cell cycle, annexin V and Mitochondrial membrane potential studies were performed
for the most active compound. Furthermore, Gal-1 inhibition was confirmed by ELISA and fluorescence
spectroscopy.

Results:
Among all, compound 6g 3-(2-(2-(pyridin-2-ylmethylene) hydrazineyl) thiazol-4-yl)-2H-chromen-2-
one exhibited promising growth inhibition against HCT-15 colorectal cancer cells with an IC50 value of 1.28 ±
0.14 µM. The characteristic apoptotic morphological features like chromatin condensation, membrane blebbing
and apoptotic body formation were clearly observed with compound 6g on HCT-15 cells using DAPI staining
studies. Further, annexin V-FITC/PI assay confirmed effective early apoptosis induction by treatment with compound
6g. Loss of mitochondrial membrane potential and enhanced ROS generation were confirmed with JC-1
and DCFDA staining method, respectively by treatment with compound 6g, suggesting a possible mechanism
for inducing apoptosis. Moreover, flow cytometric analysis revealed that compound 6g blocked G0/G1 phase of
the cell cycle in a dose-dependent manner. Compound 6g effectively reduced the levels of Gal-1 protein in a
dose-dependent manner. The binding constant (Ka) of 6g with Gal-1 was calculated from the intercept value
which was observed as 1.9 x 107 M-1 by Fluorescence spectroscopy. Molecular docking studies showed strong
interactions of compound 6g with Gal-1 protein.

Conclusion:
Our studies demonstrate the anticancer potential and Gal-1 inhibition of heterocyclic imines linked
coumarin-thiazole hybrids.
Neuropsychiatric Aspects in Men with Klinefelter Syndrome
Authors: Giagulli Vito Angelo , Campone Beatrice , Castellana Marco , Salzano Ciro , Fisher Alessandra Daphne , de Angelis Cristina , Pivonello Rosario , Colao Annamaria , Pasquali Daniela , Maggi Mario , Triggiani Vincenzo 
Published: February 2019

Background and objective: Klinefelter Syndrome (KS) is the most common sex chromosome aneuploidy (47, XXY) and cause of male hypergonadotropic hypogonadism. It is characterized by an extreme clinical heterogeneity in presentation, including infertility, hypogonadism, language delay, metabolic comorbidities, and neurocognitive and psychiatric disorders. Since testosterone is known to have organizational, neurotrophic and neuroprotective effects on brain, the condition of primary hypogonadism could play a role. Moreover, given that KS subjects have an additional X, genes on the extra-chromosome could also exert a significant impact. The aim of this narrative review is to analyze the available literature on the relationship between KS and neuropsychiatric disorders.Methods:To extend to the best of published literature on the topic, appropriate keywords and MeSH terms were identified and searched in Pubmed. Finally, references of original articles and reviews were examined.Results:Both morphological and functional studies focusing on the brain showed that there were important differences in brain structure of KS subjects. Different psychiatric disorders such as Schizophrenia, autism, attention deficit hyperactivity disorder, depression and anxiety were frequently reported in KS patients according to a broad spectrum of phenotypes. T supplementation (TRT) was not able to improve the psychotic disorders in KS men with or without overt hypogonadism.Conclusion:Although the risk of psychosis, depression and autism is increased in subjects with KS, no definitive evidence has been found in studies aiming at identifying the relationship between aneuploidy, T deficit and the risk of psychiatric and cognitive disorders in subjects affected by KS.
Microbiota of a Full-scale UASB Reactor Treating Brewery Wastewater Using Illumina MiSeq Sequencing
Authors: Enitan Abimbola M. , Kumari Sheena , Swalaha Feroz M. , Odiyo John O. , Bux Faizal 
Published: February 2019

Background:
The efficiency of biological wastewater treatment plant is determined by bacterial metabolism. There are data on the effect of operational parameters on microbial consortia present in laboratory scale reactor. However, knowledge on the full-scale reactor is still limited at present, hence the need to define the relations between the microbial structure and the performance of full-scale reactor.

Objective:
In this study, the microbial community structure in a full-scale UASB reactor treating brewery wastewater was assessed using metagenomics Next-Generation Sequencing technique.

Method:
Granular sludge samples were collected from the UASB reactor treating brewery wastewater and extracted genomic DNA was amplified using barcoded bacterial primer sets targeting V3-V4 region of the 16S rRNA genes on sequencing Illumina MiSeq platform.

Results:
The taxonomic analysis revealed the abundance of bacteria (~95%) with considerable Archaea community (~2%) in the granular sludge. After trimming, 18 bacterial phyla, 29 orders, 36 families and 44 genera were recovered from the 48,488 sequences reads of the 16S rRNA genes analysed, where the most abundant community belongs to Firmicutes, Bacteroidetes, Synergistetes and Proteobacteria phyla.

Conclusion:
For a sustainable bioenergy generation, understanding the mechanisms of anaerobic system in relation to microbial community is an important factor to increase the production of biogas production during wastewater treatment. To the best of our knowledge, this report is one of the studies that explored and described bacterial diversity and community structure of a full-scale UASB reactor treating brewery wastewater using high-throughput sequencing. This study provides insight into the dominant microbial community and their phylogenetic diversity in biogas producing reactor.
Predominance of CTX-M Type Extended Spectrum β-lactamase (ESBL) Producers Among Clinical Isolates of Enterobacteriaceae in a Tertiary Care Hospital, Kathmandu, Nepal
Authors: Lohani Biraj , Thapa Mina , Sharma Laxmi , Adhikari Hriush , Sah Anil K. , Khanal Arun B. , Basnet Ranga B. , Aryal Manita 
Published: February 2019

Background:ESBL problem is increasing worldwide and only limited studies on genes of ESBL are performed in Nepal.Objectives:We aimed to focus on the molecular detection of plasmid-mediatedblaTEM,blaSHVandblaCTX-Mgenes among the ESBL producing Enterobacteriaceae from different clinical samples.Methods:A total of 550 clinical samples were processed and organisms of Enterobacteriaceae were identified using standard microbiological process. ESBL producers were screened and confirmed using modified Kirby Bauer disc diffusion method by CLSI guidelines. Plasmids extracted from the confirmed ESBL positives were the template for PCR.blaSHV,blaTEMandblaCTX-Mgenes were amplified using specific primers of respective genes by uniplex PCR. The presence of these genes was confirmed by gel electrophoresis.Results:Among 550 different clinical samples 343 (62.36%) were culture positive. Of which, 157 (45.57%) belonged to Enterobacteriaceae.Escherichia coli(45.9%) was predominant. Of these 33.2% (52/157) isolates ESBL positive. ESBL-E. coli(52.8%) were prevalent. All ESBL positive organisms were sensitive to imipenem. Of confirmed ESBL positives, 34.6% harboringblaTEMgene, 30.8% harboringblaSHVgene andblaCTX-Mgenes were present in all ESBL producers. Twenty-eightout of 52 (53.9%) isolates harbored multipleblagenes, the most common combination beingblaCTX-M+blaTEM(21.2%).Conclusion:We report 100% plasmid mediated CTX-M genotype among ESBL producers which might indicate rapid dissemination ofblaCTX-Mgenes from the community to the patients. Besides, there is a need for regular monitoring of antibiotic resistance in the country and de-escalate the use of antibiotics so as to preserve the antibiotics for future generation.
Optimized V-Shaped Beam Micro-Electrothermal Actuator Using Particle Swarm Optimization (PSO) Technique
Authors: Osman Salah Eldeen , Zarog Musaab 
Published: February 2019

Background:Electrothermal microactuators are very promising for wide range of Microelectromechanical Systems (MEMS) applications due to the low voltage requirement and large force produced.Method:A new optimized V-beam electrothermal micro actuator was implemented in variable optical attenuator. In this work, Particle Swarm Optimization (PSO) technique is proposed to design the Vshaped beam.Result:The approach has successfully improved both angular displacement & output force of the microactuator. Entropy generation rate was used as optimization criteria.