bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination Therapies for Hidradenitis Suppurativa: A Retrospective Chart Review of 31 Patients
Authors: McPhie Meghan L. , Bridgman Alanna C. , Kirchhof Mark G. 
Published: January 2019

Background: Although a variety of medical and surgical interventions exist for the treatment of hidradenitis suppurativa (HS), it remains a challenging disease to manage because of its variable presentation and unpredictable clinical course. Apart from the combination of clindamycin and rifampin, the success of other combination therapies is largely unknown. Objectives: The goal of our study was to examine the clinical utility of various combination therapies for the treatment of HS. Methods: We conducted a qualitative retrospective chart review of 31 patients with dermatologist-diagnosed HS who were seen at an academic teaching hospital between 2014 and 2018. Demographic data, disease location, disease severity, and treatment protocol were retrieved for analysis. Hurley stage was used to classify disease severity on initial presentation, and the International Hidradenitis Suppurativa Severity Score System (IHS4) was used to track changes across visits. Results: Of the 31 patients (Mage = 37.7 years; 67.7% female) included in the study, 6 (19.4%), 11 (35.5%), and 14 (45.2%) patients were classified as Hurley stages I, II, and III, respectively. Although no statistical results are provided because of the small sample size, we have identified several drug combinations that show promising clinical response for patients with HS based on their IHS4 score, such as isotretinoin/spironolactone for mild disease, isotretinoin or doxycycline with adalimumab for moderate disease, and cyclosporine/adalimumab for severe disease. Conclusions: This preliminary work demonstrates that HS treatment with combination therapy appears to be a promising method of disease management.
Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it
Authors: Buhrmann Constanze , Yazdi Mina , Popper Bastian , Shayan Parviz , Goel Ajay , Aggarwal Bharat B , Shakibaei Mehdi 
Published: January 2019

Although much is understood about the proinflammatory cytokine TNF-α, very limited data are available about TNF-β (lymphotoxin). Whether TNF-β can induce the proliferation of tumor cells, how TNF-β-induced proliferation of tumor cells is affected by natural products such as resveratrol and the role of NF-κB in this process, is not understood. In the present study, we used clonogenic and cytotoxic methods to show the effect of TNF-β on cell proliferation. We also examined the impact of resveratrol on TNF-β-promoted proliferation and on NF-κB activation in HCT116 colorectal cancer (CRC). Our findings showed that TNF-β induced the proliferation and invasion in CRC cells and this was comparable with that of TNF-α. TNF-β-stimulated proliferation of CRC cells was blocked via anti-TNF-β-receptor. We found that resveratrol reversed the TNF-β-induced proliferation and invasion of CRC cells, and this correlated with the suppression of TNF-β-stimulated NF-κB signaling. Like resveratrol, IκB-kinase (IKK) inhibitor (BMS-345541), also reversed TNF-β-stimulated proliferation, NF-κB activation and these were mediated through inhibition of IκB-kinase, phosphorylation of IκBα, suppression of phosphorylation, and nuclear translocation of the p65 subunit of NF-κB. Furthermore, resveratrol similar to BMS-345541 suppressed TNF-β-promoted NF-κB-mediated gene biomarkers linked with proliferation, apoptosis, and invasion. Overall, our findings indicate for the first time that TNF-β/TNF-β-receptor signaling is involved in proliferation of CRC cells in parallel to TNF-α, and that resveratrol down-modulates TNF-β/TNF-β-receptor-mediated inflammatory response, at least in part through down modulating NF-κB activation, thereby regulating tumor cell growth. Impact statement The mechanism by which natural products such as resveratrol suppresses TNF-β-promoted tumor cell proliferation, invasion, and colony formation is unknown. In this study, we explored for the first time the effect of resveratrol on the proinflammatory cytokine TNF-β-, compared to TNF-α-stimulated proliferative and pro-inflammatory signaling in HCT116 cells. Our findings suggest that expression of TNF-β and TNF-β-receptor, like TNF-α, can lead to activation of inflammatory transcription factor (NF-κB) and NF-κB-regulated gene biomarkers, which are involved in the promotion of cancer proliferation, invasion, metastasis, and cell survival of tumor. Resveratrol can block TNF-β/TNF-β-receptor-induced activation of NF-κB, NF-κB-modulated gene products, and inhibition of caspase-3 cleavage. These results highlight the therapeutic effect of resveratrol-mediated anti-tumor activity by multitargeting cellular signaling pathways.
Tipping the scales: Provider perspectives on a multi-disciplinary approach to obesity
Authors: Bright Dellyse , O’Hare Katherine , Beesley Rebecca , Tapp Hazel 
Published: January 2019

Obesity is a costly and complex health issue that precipitates and/or complicates many medical conditions. Clinical recommendations include a comprehensive approach to weight loss with a combination of diet, physical activity, behavioral interventions, pharmacotherapy or surgery to achieve weight loss. Care in the primary care setting is integral in obesity management. Outside of their clinical role, primary care physicians serve as role models, educators, and promoters of healthy lifestyle practices and leaders in obesity treatment. Physician recommendations have consistently been shown to exert a powerful influence on patient behavior, but there is a substantial gap between patients who would benefit from obesity care and those receiving it. Providers, especially primary care, cite many obstacles to addressing obesity including lack of time, expertise, and resources. This review focuses on describing the feasibility and evidence for tackling obesity through provider-led multidisciplinary weight management programs. A literature search was conducted in Med Line and PubMed for published articles on multidisciplinary weight management programs that included lifestyle modification (diet and exercise), behavioral modification and a physician (MD/DO) with one or more of the following multidisciplinary team members: nutritionist/registered dietician (RD), behavioral health provider (BH), case manager (CM), pharmacist (Pharm), nursing (RN), and research staff. Relevant articles from bibliographies of systematic reviews/meta-analyses were included as well. Ten studies qualified, and we organized the articles to discuss the following three themes: diet and exercise, behavioral therapies and barriers, and facilitators for clinical weight management programs. The studies in this mini-review of multidisciplinary weight programs that included physicians reiterate the guidelines for successful treatment of obesity, with more research needed to fully understand how primary care providers can assist higher risk patient populations, particularly those of lower socioeconomic status who are disproportionally impacted by obesity. Impact statement Obesity is a major multi-faceted, chronic disease that increases the risk of morbidity and mortality of children and adults particularly impacting high-risk populations and those of lower socioeconomic status. Given provider time constraints, models of care to effectively and efficiently address obesity in primary care are key. Although physician recommendations can exert a powerful influence on behavior, providers often feel powerless to adequately address obesity due to the complexity of physical and behavioral health problems. This mini-review focuses on describing the feasibility and evidence for tackling obesity through provider-led multidisciplinary weight management programs.
Serum zonulin is elevated in IBS and correlates with stool frequency in IBS‐D
Authors: Singh Prashant , Silvester Jocelyn , Chen Xinhua , Xu Hua , Sawhney Veer , Rangan Vikram , Iturrino Johanna , Nee Judy , Duerksen Donald R. , Lembo Anthony 
Published: January 2019

BackgroundStudies have shown increased intestinal permeability in irritable bowel syndrome. Validating serum biomarkers for altered intestinal permeability in irritable bowel syndrome will facilitate research and pathophysiology‐based therapy.ObjectiveTo measure serum zonulin and intestinal fatty acid binding protein levels in diarrhea‐predominant irritable bowel syndrome and constipation‐predominant irritable bowel syndrome and compare with healthy controls and celiac disease.MethodsSerum zonulin and intestinal fatty acid binding protein levels were measured using enzyme‐linked immunosorbent assays in constipation‐predominant irritable bowel syndrome (n = 50), diarrhea‐predominant irritable bowel syndrome (n = 50), celiac disease (n = 53) and healthy controls (n = 42). Irritable bowel syndrome symptom severity was measured using the irritable bowel syndrome‐symptom severity scale.ResultsPatients with constipation‐predominant irritable bowel syndrome and diarrhea‐predominant irritable bowel syndrome had higher zonulin levels compared with healthy controls (p = 0.006 and 0.009 respectively), which was comparable to those with active celiac disease. Although zonulin levels did not correlate with the overall irritable bowel syndrome symptom severity scale, it positively correlated with stool frequency per week (p = 0.03) and dissatisfaction with bowel habits (p = 0.007) in diarrhea‐predominant irritable bowel syndrome. Patients with diarrhea‐predominant irritable bowel syndrome and constipation‐predominant irritable bowel syndrome had lower intestinal fatty acid binding protein levels compared with celiac patients (p = 0.005 and p = 0.047 respectively).ConclusionSerum zonulin is upregulated in irritable bowel syndrome and the levels are comparable to those in celiac disease. Zonulin levels correlated with severity of bowel habits in diarrhea‐predominant irritable bowel syndrome. Intestinal fatty acid binding protein levels in irritable bowel syndrome patients were not increased suggesting no significant increase in enterocyte death.
Dynamic Changes of Cardiac Repolarization Instability during Exercise Testing
Authors: HAMM WOLFGANG , VON STÜLPNAGEL LUKAS , RIZAS KONSTANTINOS D. , VDOVIN NIKOLAY , KLEMM MATHIAS , BAUER AXEL , BRUNNER STEFAN 
Published: January 2019

ABSTRACT

Introduction
Physical exercise triggers efferent cardiac sympathetic activation. Here, we tracked the spatiotemporal properties of cardiac repolarization on a beat-to-beat basis throughout a standardized exercise test and hypothesized a detectable change at the point of the anaerobic threshold (AT).

Methods
The study included 20 healthy adults (age 35.3 ± 6.7 yr) undergoing a standardized incremental exercise test on a cycle ergometer. During exercise testing, high-resolution (2000 Hz) ECG monitoring in Frank lead configuration was performed. Three-dimensional beat-to-beat repolarization instability (dT°) was assessed by a novel vector-based method according to a previously published technology. In parallel, the lactate threshold (LT) was detected according to Dickhuth and Mader.

Results
We could identify a characteristic pattern of dT° signal during exercise testing. With increasing physical activity, dT° increased concordantly to heart rate. At an average of 164 ± 38 W, dT° and heart rate abruptly showed a discordant behavior, characterized by a transient drop of dT°. The maximal discordance between dT° and heart rate was defined as ATdT° and highly significantly correlated with LTDickhuth (r = 0.841, P < 0.001) and LTMader (r = 0.819, P < 0.001), which were at 156 ± 39 and 172 ± 46 W, respectively. The characteristic of dT° could not be provoked by fast atrial pacing in the absence of exercise.

Conclusions
Repolarization instability shows a characteristic pattern during standardized exercise in healthy individuals that allows for a noninvasive estimation of AT.
Trends in emergency department visits in Lubbock from 2011-2017
Authors: Jaroudi Sarah , Yang Shengping , Berdine Gilbert 
Published: January 2019

To determine trends in daily emergency department (ED) visits, a preliminary retrospective study was done to analyze the relationship of long-term trends, day of week, and month of year to ED volume at University Medical Center in Lubbock, TX. Local data were collected from January 1, 2011, through December 31, 2017. An increase in ED visits from 2011 to 2014 was followed by a decrease in ED visits from 2014 to 2017. The best fit third order polynomial was “ ” with y=number of ED visits and x=cumulative day. The busiest day of the week was Monday with an average of 235.6 visits per day. Throughout the week, ED visits decreased to a minimum value of 201.9 visits per day on Saturday. The differences between each day of the week were significant (p < 0.001). Seasonal trends were present with peaks during February and September. The differences among months were significant (p < 0.001). The total variance of the ED visit data was decreased after adjusting for the long-term trend, day of week, and month of year. These adjustments remove noises not relevant to the study goal and are necessary for further studies testing hypotheses about factors affecting ED visits that may not be uniformly distributed over time.
Caregiver-implemented intervention for an adult with autism spectrum disorder and complex communication needs
Authors: Hong Ee Rea , Morin Kristi , Ganz Jennifer B , Genc-Tosun Derya , Gregori Emily V , Svenkerud-Hale Nicole , Boles Margot B 
Published: January 2019

Background/Aims: Individuals with autism spectrum disorder often have significant speech deficits, or complex communication needs. People with complex communication needs frequently reach adulthood without sufficient tools to communicate effectively and require instruction in the use of augmentative and alternative communication. Because communication is ubiquitous, best practice in augmentative and alternative communication instruction involves primary communication partners, such as caregivers. The aim of this study was to evaluate the efficacy of the use of a speech generating app via a tablet, as implemented by a caregiver, to increase requesting in an adult with autism spectrum disorder. Methods: This case study is a pilot study involving the provision of instruction to a primary caregiver of a young woman with autism spectrum disorder and complex communication needs. First, the primary caregiver was trained to use the speech generating app. After the primary caregiver met the performance criteria, she taught the woman with autism spectrum disorder and complex communication needs how to use the app independently. Findings: The caregiver quickly learned the steps of implementing the augmentative and alternative communication intervention and maintained use of these skills at high rates several months after the intervention was completed. Furthermore, the young woman with complex communication needs also increased use of augmentative and alternative communication, although her results were variable and were not maintained. Conclusions: Despite the positive findings from this study regarding the accuracy of the primary caregiver's intervention implementation, future research should examine a better way to meet the needs of adult people with autism spectrum disorder and complex communication needs when using augmentative and alternative communication systems.
Lexicografia Pedagógica
Authors: Daré Vargas Mariana 
Published: January 2019

O objetivo deste artigo é apresentar reflexões sobre questões teóricas relacionadas à Lexicografia Pedagógica. Resgatam-se as origens dessa disciplina, no final do século XIX e começo do século XX, quando da mudança do paradigma de ensino de línguas (MOLINA GARCÍA, 2006). Apresentam-se conceitos de Lexicografia Pedagógica atribuídos por especialistas (DUBOIS; DUBOIS, 1970; RUNDELL, 1998; HARTMANN, 2001; MOLINA GARCÍA, 2006; DURAN; XATARA, 2007; DURAN, 2008; HERNÁNDEZ, 2008; WELKER, 2008; KRIEGER, 2011; WELKER, 2011; DE SCHRYVER, 2012). Por fim, discutem-se as áreas com as quais essa ciência faz interface e propõe-se o panorama da Lexicografia Pedagógica em contexto brasileiro, proposta ampliada de Duran e Xatara (2007), da qual fazem parte, além de aluno(a), professor(a), lexicógrafo(a) e editor(a), o Governo Federal e as publicações especializadas.
Lexicografia pedagógica da língua portuguesa e Dialetologia
Authors: Paim Marcela Moura Torres , Santana Isamar Neiva 
Published: January 2019

Este artigo busca fazer uma reflexão sobre a importância da relação da Lexicografia com a Dialetologia na utilização de dicionários escolares. Os instrumentos utilizados para as análises foram os dados do Projeto Atlas Linguístico do Brasil no intuito de verificar se os dicionários escolares investigados apresentavam as lexias que se apresentavam enraizadas em diferentes áreas e vivas no vocabulário ativo de seus falantes. Com base na observação de dicionários escolares, chegou-se à conclusão de que nem sempre essas obras completam, com informações dialetais, as lacunas deixadas pelos verbetes no que se refere à inclusão de dados da língua oral, sobretudo os coletados em pesquisas geolinguísticas.
Dicionário em sala de aula
Authors: Ribeiro Thiago Leonardo , Ramos Pinto Vera Maria 
Published: January 2019

Neste artigo, temos como objetivo fazer uma análise contrastiva entre quatro dos 19 dicionários selecionados pelo Programa Nacional do Livro Didático, PNLD 2012: Dicionários, dois do Tipo 2 e dois do Tipo 3, a fim verificar os critérios utilizados pelos lexicógrafos na composição destes dicionários no que diz respeito à macro e à microestrutura textual. Neste trabalho, também, abordamos o livro Com direito à palavra: dicionários em sala de aula, uma publicação do Ministério da Educação e Cultura que acompanha cada acervo dos dicionários escolares que foram avaliados e selecionados pelo PNLD 2012 e tem como propósito apresentar aos professores o mundos dos dicionários quanto às características gerais desses acervos, esperando que o uso desses materiais possa ser otimizado.
“The moment I realized I am plurilingual”: Plurilingual tasks for creative representations in EAP at a Canadian university
Authors: Galante Angelica 
Published: January 2019

AbstractIn many urban settings across the globe, English for Academic Purposes (EAP) classes are inherently multilingual and provide unique possibilities to explore a wealth of languages and cultures as well as the interactions among them. Although the field of applied linguistics has historically followed monolingual ideologies, a plurilingual approach in EAP can provide insights into language practices that are situated, creative and contextualized. Raising students’ awareness of their own plurilingual and pluricultural repertoire is key to preparing them to make mindful decisions about culture and language use in real-life situations; plurilingual instruction incudestranslanguaging, validating plurilingual identities, as well as understandingpluriculturalism, all of which can open up possibilities for creativity in culture and language use. While research shows plurilingual-inspired pedagogies can benefit language learning, little is known about the extent to which they can enhance creative representations of language and culture. This article reports results from a study on the effects of plurilingual instruction on creativity in an EAP program. Seven EAP instructors delivered plurilingual tasks to adult students at a Canadian university. Data from demographic questionnaires,Language Portraits, student diaries (N=28), and classroom observations (N=21) were qualitatively analyzed and triangulated. Results suggest that the use of plurilingual tasks afforded a heightened awareness of plurilingual/pluricultural identity and validated the creative use of linguistic and cultural resources, including translanguaging. Suggestions for the inclusion of creative data collection instruments and plurilingual instruction in applied linguistics classroom research are made.
Scale-Up of Shear Thinning Fluid Mixing in an Unbaffled Stirred Vessel with Eccentrically Located and Modified Impellers
Authors: Yavuz Nihat , Sandeep K.P. 
Published: January 2019

Abstract
Mixing of a shear thinning fluid was scaled-up by maintaining equal Reynolds number (Re), tip speed, and power per volume. A standard 45° four-blade pitch blade turbine (PBT) and a modified version of the same impeller (DF-PBT) which provided simultaneous upward and downward flow were used. The impellers were located eccentrically, and the effects of scale-up were determined. The distribution of a tracer solution to evaluate mixing progress, power consumption, and flow fields were analyzed to compare the three different scale-up rules. The same endpoint of mixing was achieved in all cases of PBT with noticeable differences in flow profiles. Higher power consumption and less time were necessary to complete mixing with equal power per volume compared to that with equal Re and tip speed rules. For DF-PBT, only equal Re rule resulted in values similar to that obtained at the small scale. At a scale-up ratio of 2, the selection of scale-up rule should be based on the time and power requirements of the process. As the effects of scale-up on eccentrically located impellers do not differ significantly from those of concentrically located impellers, impellers which have complex dynamics such as DF-PBT require further studies to understand scale-up effects.
Power Supply Mode Planning of Electric Vehicle Participating in Logistics Distribution Based on Battery Charging and Swapping Station
Authors: Deng Youjun , Yu Qian , Li Bo , Gong Renjie , Chang Gong 
Published: January 2019

Abstract
Considering the operating pattern of battery charging and swapping station (BCSS) providing two power supply modes referring to battery charging mode and battery swapping mode at the same time, the power supply mode planning of electric vehicle (EV) participating in logistics distribution is conducive to decrease the operation costs. The primary contribution of this paper is to construct an optimization model with the objective of minimizing the overall cost of transportation cost and slow charging cost by considering the optimal driving route of EV, the selection of power supply mode and the slow discharging or charging management in the depot. The transportation cost is consisted of fast charging cost, battery swapping cost, battery life loss cost and vehicle loss cost. The secondary contribution of this paper is to improve a novel optimization algorithm called natural aggregation algorithm (NAA) as integer version to solve effectively the proposed model. Taking 33-node logistics distribution system as an example to carry out numerical simulation, the impacts of power supply mode planning on transportation cost and slow dis/charging cost are analyzed, the impacts of slow dis/charging strategy on the total cost are analyzed, and the effectiveness of proposed model in 13-node, 64-node, 112-node logistics distribution system are comparatively analyzed. The simulation results have demonstrated the feasibility and effectiveness of the proposed model and approach.
Directed Transport in Symmetrically Periodic Potentials Induced by Cross-Correlation among Colored Gaussian Noises
Authors: Alexandrovich Knyaz’ Igor 
Published: January 2019

Abstract
We study the noise induced directed transport of an inertial Brownian particle moving in a symmetric spatially periodic potential and is subjected to correlated colored noises. Under the assumption of small correlation times of colored fluctuations we obtain an analytical expression for resulting current in overdamped systems. Our analytical and numerical calculations indicate the directed current is controlled by the correlation parameters. It has been pointed out that the nonzero correlation time makes an important contribution to current only at large enough values of noise intensities. The role of other system parameters is investigated from the viewpoint of optimization the current amplitude.