bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Solar Wind Mach Numbers on the Occurrence Rate of Flux Transfer Events at the Dayside Magnetopause
Authors: Chen C. , Sun T. R. , Wang C. , Huang Z. H. , Tang B. B. , Guo X. C. 
Published: April 2019

AbstractAlthough many works have investigated the occurrence rate of flux transfer events (FTEs) under different upstream conditions, the relation between the upstream Mach number and the occurrence rate of FTEs remains unclear. By using global magnetohydrodynamics simulations, we study the occurrence rate of FTEs under different upstream Alvénic Mach numbers (MA). A recently developed method is used to identify the FTEs throughout the dayside magnetopause. It shows that the occurrence rate of FTEs decreases with increasing value of MA. We suggest that the magnetosheath β, which increases with increasing MA, plays an important role in the process of reconnection and thus affects the occurrence rate of FTEs. As the solar wind MA increases with increasing distance from the Sun, we speculate that the planet with a larger heliocentric distance may have less FTEs because of the increasing value of upstream MA.
Crustal Extension and Graben Formation by Fault Slip‐Associated Pore Opening, Kyushu, Japan
Authors: Wang Zhi , Fukao Yoshio , Miyakawa Ayumu , Hasegawa Akira , Takei Yasuko 
Published: April 2019

AbstractCrustal extension in graben takes place by normal (+strike‐slip) faulting, yet the physical processes involved are poorly understood. A series of shallow large earthquakes struck the Kumamoto area of Kyushu, Japan, in 2016. The Mw7.0 main shock was a slip along the southern boundary of the Beppu‐Shimabara Graben, where NS‐extensional crustal deformation is now taking place. We conducted a tomographic inversion for crustal P and S velocities and Poisson's ratio (Vp, Vs, and σ) in Kyushu. The most outstanding feature in this region is a Beppu‐Shimabara Graben‐parallel belt of low Vp and Vs anomalies at depths of the upper crust. We find that within the belt dVs/Vs ≈ dVp/Vp (<0) in marked contrast to relations in other low‐velocity regions where |dVs/Vs| > |dVp/Vp|. This observation can be interpreted as due to water‐saturated, oblate‐spheroid pores with either of two very different geometries: one almost round pore and the other very flat pore. We calculate 3‐D density anomaly distributions and 2‐D gravity anomaly profiles for these two pore models. The gravity anomaly map calculated for spherical pores shows a significant negative anomaly belt that spatially agrees with observed Bouguer anomaly map. The spatial agreement is very poor if pores are modeled as flat. This and extensive seismicity within Beppu‐Shimabara Graben imply significance of fault‐associated round pore formation in the process of graben opening. Seismic tomography combined with gravity and poroeasticty analyses can constrain the crack/pore state of extensionally deforming crust.
Global Distribution of the Solar Wind Flux and Velocity From SOHO/SWAN During SC‐23 and SC‐24
Authors: Koutroumpa D. , Quémerais E. , Ferron S. , Schmidt W. 
Published: April 2019

AbstractWe analyze SOHO (SOlar Heliospheric Observatory)/SWAN (Solar Wind ANisotropy) hydrogen Lyman‐α data collected between 1996 and 2018 to derive the solar wind latitudinal distribution over time. Full‐sky interplanetary Lyman‐α maps are inverted to derive the total hydrogen ionization rate latitude profiles, normalized to proton charge‐exchange and photoionization. Using Interplanetary Scintillation velocities to calculate the velocity‐dependent charge‐exchange cross‐sections, we produce the solar wind flux latitudinal profiles. Finally, we compute solar wind velocity latitude profiles, based on the dynamic pressure and energy flux conservation (calculated from OMNI data) over latitude. SWAN reproduces the Interplanetary Scintillation velocity profiles up to at least ±60°, and also agrees with Ulysses in situ measurements for solar minimum periods in 1996–1997 and 2007. During solar maximum, discrepancies are more frequent because in situ data reflect local solar wind conditions, while SWAN data reflect global conditions in the heliosphere.
The mevalonate coordinates energy input and cell proliferation
Authors: Gong Li , Xiao Yi , Xia Fan , Wu Pei , Zhao Tingting , Xie Shulin , Wang Ran , Wen Qiaocheng , Zhou Wensu , Xu Huilan , Zhu Lingyan , Zheng Zeqi , Yang Tianlun , Chen Zihua , Duan Qiong 
Published: April 2019

AbstractThe mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the mevalonate pathway inhibits the growth and proliferation of colon cancer cell lines. The results of transcriptomic and proteomic assays suggested that the mevalonate pathway controls multiple signaling pathways relevant to cell proliferation, and the results were further confirmed using western blot, PCR, and immunofluorescence assays. As cell proliferation is an energy-consuming process, we postulate that the mevalonate pathway may also control nutrient uptake to coordinate the processes of energy supply and cell proliferation. Here, we found that lovastatin, a mevalonate pathway inhibitor, suppresses glucose and amino acid uptake and lactate acid production. More importantly, mevalonic acid itself is sufficient to promote glucose uptake by colon cancer cells. In addition, we found that colon cancer tissues displayed a higher expression of mevalonate pathway enzymes, which may promote cell growth and stimulate energy uptake. Together, our findings establish the mevalonate pathway as a critical regulator in coordinating energy input and cell proliferation.
Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids
Authors: Boisvert Erin M. , Means Robert E. , Michaud Michael , Madri Joseph A. , Katz Samuel G. 
Published: April 2019

AbstractNeonatal hypoxic injury (NHI) is a devastating cause of disease that affects >60% of babies born with a very low birth weight, resulting in significant morbidity and mortality, including life-long neurological consequences such as seizures, cerebral palsy, and intellectual disability. Hypoxic injury results in increased neuronal death, which disrupts normal brain development. Although animal model systems have been useful to study the effects of NHI, they do not fully represent the uniqueness and complexities of the human brain. To better understand the effects of hypoxia on human brain development, we have generated a brain organoid protocol and evaluated these cells over the course of 6 months. As anticipated, the expression of a forebrain marker, FOXG1, increased and then remained expressed over time, while there was a transition in the expression of the deep-layer (TBR1) and upper-layer (SATB2) cortical markers. In addition, ventral genes (Eng1 and Nkx2.1) as well as markers of specialized nonneuronal cells (Olig2 and GFAP) also increased at later time points. We next tested the development of our in vitro cerebral organoid model at different oxygen concentrations and found that hypoxia repressed gene markers for forebrain, oligodendrocytes, glial cells, and cortical layers, as well as genes important for the migration of cortical neurons. In contrast, ventral markers were either unaffected or even increased in expression with hypoxic insult. Interestingly, the negative effect of hypoxia on the dorsal brain genes as well as oligodendrocytes, and neuronal progenitors could be mitigated by the use of minocycline, an FDA-approved small molecule. Taken together, we have generated a unique and relevant in vitro human brain model system to study diseases such as NHI as well as their potential treatments. Using this system, we have shown the efficacy of minocycline for human NHI.
Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
Authors: Wu Yi-Hui , Huang Yu-Fang , Chen Chien-Chin , Chou Cheng-Yang 
Published: April 2019

AbstractWe studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL11A1 expression levels, as well as resistance to cisplatin or paclitaxel. SC66 inhibited phosphorylation of Akt and its downstream effectors 4EBP1 and p70S6 kinase. SC66 also attenuated expression of TWIST1 and Mcl-1, factors important in cell invasiveness and anti-apoptosis, respectively. SC66-sensitized chemoresistant cells to cisplatin and paclitaxel treatment, and promoted apoptosis. In addition, SC66 inhibited COL11A1 expression via decreased binding of CCAAT/enhancer-binding protein beta (c/EBPβ), reducing chemoresistance and decreasing binding of nuclear transcription factor Y (NF-YA) to COL11A1. A mouse xenograft experiment demonstrated that SC66 treatment caused a reduction in tumor formation and enhanced the therapeutic efficacy of cisplatin. This study demonstrates the role of Akt in ovarian tumor progression and chemoresistance, and supports the application of SC66 as a therapy for ovarian cancer.
IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis
Authors: Vecchio Eleonora , Golino Gaetanina , Pisano Antonio , Albano Francesco , Falcone Cristina , Ceglia Simona , Iaccino Enrico , Mimmi Selena , Fiume Giuseppe , Giurato Giorgio , Britti Domenico , Scala Giuseppe , Quinto Ileana 
Published: April 2019

AbstractIncreasing evidence supports the involvement of IBTK in cell survival and tumor growth. Previously, we have shown that IBTK RNA interference affects the wide genome expression and RNA splicing in cell-type specific manner. Further, the expression of IBTK gene progressively increases from indolent to aggressive stage of chronic lymphocytic leukemia and decreases in disease remission after therapy. However, the role of IBTK in tumorigenesis has not been elucidated. Here, we report that loss of the murine Ibtk gene raises survival and delays tumor onset in Eμ-myc transgenic mice, a preclinical model of Myc-driven lymphoma. In particular, we found that the number of pre-cancerous B cells of bone marrow and spleen is reduced in Ibtk−/−Eμ-myc mice owing to impaired viability and increased apoptosis, as measured by Annexin V binding, Caspase 3/7 cleavage assays and cell cycle profile analysis. Instead, the proliferation rate of pre-cancerous B cells is unaffected by the loss of Ibtk. We observed a direct correlation between Ibtk and myc expression and demonstrated a Myc-dependent regulation of Ibtk expression in murine B cells, human hematopoietic and nonhematopoietic cell lines by analysis of ChIP-seq data. By tet-repressible Myc system, we confirmed a Myc-dependent expression of IBTK in human B cells. Further, we showed that Ibtk loss affected the main apoptotic pathways dependent on Myc overexpression in pre-cancerous Eμ-myc mice, in particular, MCL-1 and p53. Of note, we found that loss of IBTK impaired cell cycle and increased apoptosis also in a human epithelial cell line, HeLa cells, in Myc-independent manner. Taken together, these results suggest that Ibtk sustains the oncogenic activity of Myc by inhibiting apoptosis of murine pre-cancerous B cells, as a cell-specific mechanism. Our findings could be relevant for the development of IBTK inhibitors sensitizing tumor cells to apoptosis.
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
Authors: Al-toub Mashael , Almohawes Mohammad , Vishnubalaji Radhakrishnan , Alfayez Musaad , Aldahmash Abdullah , Kassem Moustapha , Alajez Nehad M. 
Published: April 2019

AbstractThe interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM) derived from human bone marrow stromal stem cells (hBMSCs). Regarding the underlying molecular mechanism, we have identified CXCR7 as highly expressed by MCF7 cells and that it mediated the enhanced growth in response to hBMSC CM. Regarding the clinical relevance, we found an inverse correlation between the level of tumor gene expression of CXCR7 in bladder, breast, cervical, kidney, liver, lung, pancreatic, stomach, and uterine cancers, and patients’ overall survival. Interestingly, significant positive correlation between CXCR7 and CXCL12 gene expression (Pearson = 0.3, p = 2.0 × 10–16) was observed in breast cancer patients, suggesting a biological role for the CXCR7/CXCL12 genetic circuit in breast cancer biology. Our data provide insight into the molecular mechanisms by which stromal-derived microenvironmental cues mediate CXCR7 signaling and growth enhancement of breast cancer cells. Therapeutic targeting of this circuit might provide novel therapeutic opportunity for breast cancer.
Anomalous Nernst effect beyond the magnetization scaling relation in the ferromagnetic Heusler compound Co2MnGa
Authors: Guin Satya N. , Manna Kaustuv , Noky Jonathan , Watzman Sarah J. , Fu Chenguang , Kumar Nitesh , Schnelle Walter , Shekhar Chandra , Sun Yan , Gooth Johannes , Felser Claudia 
Published: April 2019

AbstractApplying a temperature gradient in a magnetic material generates a voltage that is perpendicular to both the heat flow and the magnetization. This phenomenon is the anomalous Nernst effect (ANE), which was long thought to be proportional to the value of the magnetization. However, more generally, the ANE has been predicted to originate from a net Berry curvature of all bands near the Fermi level (EF). Subsequently, a large anomalous Nernst thermopower ($${\boldsymbol{S}}_{{\boldsymbol{yx}}}^{\boldsymbol{A}}$$

S

yx

A

) has recently been observed in topological materials with no net magnetization but a large net Berry curvature [Ωn(k)] around EF. These experiments clearly fall outside the scope of the conventional magnetization model of the ANE, but a significant question remains. Can the value of the ANE in topological ferromagnets exceed the highest values observed in conventional ferromagnets? Here, we report a remarkably high $${\boldsymbol{S}}_{{\boldsymbol{yx}}}^{\boldsymbol{A}}$$

S

yx

A

-value of ~6.0 µV K−1 in the ferromagnetic topological Heusler compound Co2MnGa at room temperature, which is approximately seven times larger than any anomalous Nernst thermopower value ever reported for a conventional ferromagnet. Combined electrical, thermoelectric, and first-principles calculations reveal that this high-value of the ANE arises from a large net Berry curvature near the Fermi level associated with nodal lines and Weyl points.
Analysis of oral microbiota in patients with obstructive sleep apnea-associated hypertension
Authors: Ko Chih-Yuan , Hu An-Ke , Chou Dylan , Huang Li-Mei , Su Huan-Zhang , Yan Fu-Rong , Zhang Xiao-Bin , Zhang Hua-Ping , Zeng Yi-Ming 
Published: April 2019

AbstractObstructive sleep apnea–hypopnea syndrome (OSAHS) is an independent risk factor for hypertension (HTN). The oral microbiota plays a pathophysiological role in cardiovascular diseases; however, there are few reports directly investigating and identifying the organisms involved in OSAHS-related HTN. Therefore, this study aimed to identify those organisms. We obtained 139 oral samples and determined the microbiome composition using pyrosequencing and bioinformatic analyses of the 16S rRNA. We examined the fasting levels of cytokines and homocysteine in all participants and analyzed the correlations between the oral microbiota and homocysteine levels. We determined the molecular mechanism underlying HTN by investigating the genetic composition of the strains in the blood. We detected higher relative abundances of Porphyromonas and Aggregatibacter and elevated proinflammatory cytokines in patients with OSAHS of varying severity compared with individuals without OSAHS; however, the two organisms were not measured in the blood samples from all participants. High levels of specific Porphyromonas bacteria were detected in patients with OSAHS with and without HTN, whereas the relative abundance of Aggregatibacter was negatively correlated with the homocysteine level. The receiver operating characteristic curve analysis of controls and patients with OSAHS resulted in area under the curve values of 0.759 and 0.641 for patients with OSAHS with or without HTN, respectively. We found that the predictive function of oral microbiota was different in patients with OSAHS with and without HTN. However, there was no direct invasion by the two organisms causing endothelial cell injury, leading to speculation regarding the other mechanisms that may lead to HTN. Elucidating the differences in the oral microbiome will help us understand the pathogenesis of OSAHS-related HTN.
Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity
Authors: Chakraborty Manas , Tarasovetc Ekaterina V. , Zaytsev Anatoly V. , Godzi Maxim , Figueiredo Ana C. , Ataullakhanov Fazly I. , Grishchuk Ekaterina L. 
Published: April 2019

AbstractAccurate chromosome segregation relies on microtubule end conversion, the ill-understood ability of kinetochores to transit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends. The molecular requirements for this conversion and the underlying biophysical mechanisms are elusive. We reconstituted end conversion in vitro using two kinetochore components: the plus end–directed kinesin CENP-E and microtubule-binding Ndc80 complex, combined on the surface of a microbead. The primary role of CENP-E is to ensure close proximity between Ndc80 complexes and the microtubule plus-end, whereas Ndc80 complexes provide lasting microtubule association by diffusing on the microtubule wall near its tip. Together, these proteins mediate robust plus-end coupling during several rounds of microtubule dynamics, in the absence of any specialized tip-binding or regulatory proteins. Using a Brownian dynamics model, we show that end conversion is an emergent property of multimolecular ensembles of microtubule wall-binding proteins with finely tuned force-dependent motility characteristics.
Hybrid longitudinal-transverse phonon polaritons
Authors: Gubbin Christopher R. , Berte Rodrigo , Meeker Michael A. , Giles Alexander J. , Ellis Chase T. , Tischler Joseph G. , Wheeler Virginia D. , Maier Stefan A. , Caldwell Joshua D. , De Liberato Simone 
Published: April 2019

AbstractPhonon polaritons, hybrid light-matter quasiparticles resulting from strong coupling of the electromagnetic field with the lattice vibrations of polar crystals are a promising platform for mid-infrared photonics but for the moment there has been no proposal allowing for their electrical pumping. Electrical currents in fact mainly generate longitudinal optical phonons, while only transverse ones participate in the creation of phonon polaritons. We demonstrate how to exploit long-cell polytypes of silicon carbide to achieve strong coupling between transverse phonon polaritons and zone-folded longitudinal optical phonons. We develop a microscopic theory predicting the existence of the resulting hybrid longitudinal-transverse excitations. We then provide an experimental observation by tuning the resonance of a nanopillar array through the folded longitudinal optical mode, obtaining a clear spectral anti-crossing. The hybridisation of phonon polaritons with longitudinal phonons could represent an important step toward the development of phonon polariton-based electrically pumped mid-infrared emitters.
Defining the genetic and evolutionary architecture of alternative splicing in response to infection
Authors: Rotival Maxime , Quach Hélène , Quintana-Murci Lluis 
Published: April 2019

AbstractHost and environmental factors contribute to variation in human immune responses, yet the genetic and evolutionary drivers of alternative splicing in response to infection remain largely uncharacterised. Leveraging 970 RNA-sequencing profiles of resting and stimulated monocytes from 200 individuals of African- and European-descent, we show that immune activation elicits a marked remodelling of the isoform repertoire, while increasing the levels of erroneous splicing. We identify 1,464 loci associated with variation in isoform usage (sQTLs), 9% of them being stimulation-specific, which are enriched in disease-related loci. Furthermore, we detect a longstanding increased plasticity of immune gene splicing, and show that positive selection and Neanderthal introgression have both contributed to diversify the splicing landscape of human populations. Together, these findings suggest that differential isoform usage has been an important substrate of innovation in the long-term evolution of immune responses and a more recent vehicle of population local adaptation.
Closing the gap between atomic-scale lattice deformations and continuum elasticity
Authors: Salvalaglio Marco , Voigt Axel , Elder Ken R. 
Published: April 2019

AbstractCrystal lattice deformations can be described microscopically by explicitly accounting for the position of atoms or macroscopically by continuum elasticity. In this work, we report on the description of continuous elastic fields derived from an atomistic representation of crystalline structures that also include features typical of the microscopic scale. Analytic expressions for strain components are obtained from the complex amplitudes of the Fourier modes representing periodic lattice positions, which can be generally provided by atomistic modeling or experiments. The magnitude and phase of these amplitudes, together with the continuous description of strains, are able to characterize crystal rotations, lattice deformations, and dislocations. Moreover, combined with the so-called amplitude expansion of the phase-field crystal model, they provide a suitable tool for bridging microscopic to macroscopic scales. This study enables the in-depth analysis of elasticity effects for macroscale and mesoscale systems taking microscopic details into account.
Crowdsourced MRI quality metrics and expert quality annotations for training of humans and machines
Authors: Esteban Oscar , Blair Ross W. , Nielson Dylan M. , Varada Jan C. , Marrett Sean , Thomas Adam G. , Poldrack Russell A. , Gorgolewski Krzysztof J. 
Published: April 2019

AbstractThe neuroimaging community is steering towards increasingly large sample sizes, which are highly heterogeneous because they can only be acquired by multi-site consortia. The visual assessment of every imaging scan is a necessary quality control step, yet arduous and time-consuming. A sizeable body of evidence shows that images of low quality are a source of variability that may be comparable to the effect size under study. We present the MRIQC Web-API, an open crowdsourced database that collects image quality metrics extracted from MR images and corresponding manual assessments by experts. The database is rapidly growing, and currently contains over 100,000 records of image quality metrics of functional and anatomical MRIs of the human brain, and over 200 expert ratings. The resource is designed for researchers to share image quality metrics and annotations that can readily be reused in training human experts and machine learning algorithms. The ultimate goal of the database is to allow the development of fully automated quality control tools that outperform expert ratings in identifying subpar images.