bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Mortality Among Renal Transplant Patients With Invasive Pulmonary Aspergillus Infection
Authors: Balcan Baran , Ozcelik Umit , Ugurlu Aylin Ozsancakli , Aydin Mehtap , Nalcaci Serdar , Yarbug Karakayali Feza 
Published: September 2018

Introduction: Renal transplantation is the most effective and preferred definite treatment option in patients with end-stage renal disease. Due to long-term immunesuppressive treatment, renal transplant recipients become vulnerable to opportunistic infections, especially to fungal infections. Method: This was a single-center, retrospective observational study of 438 patients who underwent renal transplantation between 2010 and 2016. Results: Thirty-eight renal transplant recipients who had lower respiratory tract infection with median age of 41.5 years were evaluated for invasive pulmonary aspergillus (IPA). Of these, 52.6% were female and 84.2% had living donors. Eleven of 38 lower respiratory patients were found to have IPA infection, 5 with proven infection. Compared to patients who did not have fungal pulmonary infection, patients with invasive aspergillus were older and had high fever, galactomannan levels, and leukocyte counts. Mortality was also higher in those patients. Having fever at the baseline and IPA infection was significantly associated with mortality in univariate analysis and remained related in multivariate model after adjustment for age, gender, and fever. Conclusion: Invasive pulmonary aspergillus infection is highly associated with increased mortality rates in renal transplant patients. Fungal pulmonary infections in immune-suppressed patients should be diagnosed and treated immediately in order to avoid the life-threatening complications and may greatly improve prognosis.
Neuroform Atlas stent deployment through the Barrel vascular reconstruction device for the treatment of a wide-necked acutely ruptured basilar aneurysm
Authors: Valente Iacopo , D’Argento Francesco , Alexandre Andrea , Lozupone Emilio , Garignano Giuseppe , Pedicelli Alessandro 
Published: September 2018

Background The Barrel vascular reconstruction device is an electrolytically detachable laser-cut closed-cell stent used for neck reconstruction in wide-necked bifurcation aneurysms to support coiling without necessitating dual stent implantation. The purpose is to lower the metal-to-artery ratio and its inherent risk of thromboembolic complications of multiple stents. Case description A 53-year-old woman presenting with subarachnoid hemorrhage due to acutely ruptured basilar tip aneurysm underwent emergency endovascular embolization with the Barrel vascular reconstruction device. Since the stent did not cover the entire neck of the aneurysm, an Atlas stent was released in a Y configuration through the Barrel. The Neuroform Atlas correctly opened through the Barrel and allowed the complete exclusion of the aneurysm. Conclusion If necessary, releasing a Neuroform Atlas through a Barrel vascular reconstruction device is a feasible technique.
Diagnostic and prognostic value of HE4 in female patients with primary peritoneal carcinoma
Authors: Mi Dong , Zhang Yuexiang 
Published: September 2018

Background: HE4 is a useful tumor marker for the diagnosis of ovarian, endometrial, and fallopian tube carcinoma. Aim: The aim of our study was to investigate the value of serum HE4 compared with CA125 in the diagnosis of primary peritoneal carcinoma and the estimation of treatment response and recurrence. Methods: Serum HE4 and CA125 concentrations were measured in both primary peritoneal carcinoma patients and benign gynecological disease controls. The treatment response and recurrence were assessed by serum HE4 and CA125 levels in primary peritoneal carcinoma patients. Results: Serum HE4 and CA125 levels were significantly increased in primary peritoneal carcinoma patients compared with benign disease controls ( P<0.001). Compared with CA125, HE4 had lower sensitivity (84.2% vs. 94.7%), but higher specificity (99.2% vs. 85.3%); the combination of HE4 and CA125 led to higher sensitivity and specificity. In the receiver operating characteristic analysis, the area under the curve was 0.956 for HE4, for CA125 was 0.953, for HE4+CA125 was 0.979. Furthermore, HE4 and CA125 were closely associated with treatment response, and our results indicated that primary peritoneal carcinoma patients displayed a larger drop of HE4 compared with CA125 (75.8% vs. 61.5%). Combined with CA125, HE4 elevation better predicted recurrence in primary peritoneal carcinoma patients during the remission period after treatment. Conclusions: This study indicated that the detection of serum HE4 changes may enhance the effectiveness for detecting primary peritoneal carcinoma and estimating the outcome of treatment and recurrence in female primary peritoneal carcinoma patients.
Inter-surgeon variability in the identification of clock face landmarks when placing suture anchors in arthroscopic Bankart repair
Authors: Petrera Massimo , Ogilvie-Harris Darrell J , Theodoropoulos John S , Chahal Jaskarndip , Wasserstein David , Veillette Christian , Linda Dorota , Dwyer Tim 
Published: September 2018

Background The accuracy of surgeons in utilizing the clock face method for anchor placement has never been investigated. Our hypothesis was that shoulder arthroscopy surgeons would be able to place suture anchors at predetermined positions with accuracy and reliability. Methods Ten cadaveric shoulders were used. Five fellowship-trained shoulder arthroscopy surgeons were directed to place a suture anchor at 3:30, 4:30, and 5:30 clock in two shoulders each. The position of the anchors was determined with computed tomography. The accuracy of placement was calculated and data analyzed with one-way analysis of variance. The intraclass correlation coefficients were calculated. Results The overall accuracy was 57%. The accuracy of anchor placement at the 3:30 position was 40% (average position 2:24 o’clock), it was 50% at the 4:30 position (average position 3:42 o’clock) and 80% at the 5:30 position (average position 5:03 o’clock). No statistical difference in accuracy between the placement of the superior, middle, and inferior anchors (p = 0.145) was seen. The intraclass correlation coefficient for inter-surgeon reliability was 0.4 (fair) while the intraclass correlation coefficient for intra-surgeon reliability was 0.6 (moderate). Discussion The findings of this study suggest a moderate degree of accuracy and fair to moderate inter- and intra-surgeon reliability when using the clock face system to guide anchor placement.
Screening of the cervical spine in subacromial shoulder pain: A systematic review
Authors: Walker Tom , Salt Emma , Lynch Greg , Littlewood Chris 
Published: September 2018

Background Subacromial shoulder pain is a common clinical presentation with much diagnostic uncertainty. Some of this uncertainty relates to the involvement of the cervical spine as a source or contribution to subacromial shoulder pain. Currently, there is no accepted method of screening of the cervical spine in the presence of subacromial shoulder pain, which risks patients receiving misguided and/or ineffective interventions. Objective To evaluate approaches used to screen the cervical spine in patients with subacromial shoulder pain. Design Systematic review of randomized controlled trials. Methods Electronic searches of PEDro and MEDLINE to December 2016 were conducted. Randomized controlled trials evaluating the effectiveness of interventions within the current scope of physiotherapy comprising of adult patients complaining of subacromial shoulder pain were included. Data relating to the method of cervical spine screening were extracted and synthesized categorically. Results One hundred and two studies were included. Twenty-six (25.5%) were categorized as “No method of screening undertaken or reported,” 49 (48.0%) were categorized as “Localized cervical spine symptoms and/or radiculopathy/radicular pain,” nine (8.8%) were categorized as “Cervical examination,” two (2.0%) were categorized as “Manual testing,” two (2.0%) were categorized as “History of cervical surgery,” and 14 (13.7%) were categorized as using “Combined approaches.” Conclusion Examination of the cervical spine in patients with subacromial shoulder pain is variable in randomized controlled trials. In many instances, no or minimal attempts to screen were undertaken or reported. This has potential research and management implications and further research is indicated to facilitate development of this aspect of examination.
Numerical study on rupture process of fiber-reinforced composites
Authors: Wang Daguo , Han Chaochao , Xu Bing , Li Bin 
Published: September 2018

Introduction: This study aims to investigate the strength characteristics of fiber composites under uniaxial tensile stress. Methods: A tensile failure finite element model based on fracture mechanics was built for fiber composites. The principal stress concentration–release–transfer evolution and the crack propagation of the composites under the conditions of equal single fiber width, unequal quantity, and equal total fiber width and unequal quantity were discussed. Results: The tensile strength of the composites increased with fiber quantity when the width of each single fiber was equal. Conclusions: The tensile strength of the composites increased with fiber quantity when the total width of the composite fiber was equal.
Synthesis of magnetic Fe3O4 micro/nanospheres in organic solvent
Authors: Heng Tan , Ze Wang , Wen-sheng Tan , Xiao-ping Li , Jian-guo Qiu , Xiao-Hong Yang 
Published: September 2018

Introduction: Micro/nanostructured materials have attracted a great deal of attention, and many strategies have been developed to fabricate micro/nanostructured materials. Methods: Amine-functionalized micro/nanostructured Fe3O4 with different sizes was synthesized conveniently in organic media. The chemical structures of as-synthesized products were characterized by FTIR, TEM, SEM, and XRD. Results: The ligand binds to the Fe3O4 core by hydrogen bond between the oxygen atom on the surface of Fe3O4 and the hydrogen atom in molecular ethylenediamine. Their magnetic properties were also investigated. Conclusions: First, there is no need to control the reaction under a nitrogen atmosphere, and just one salt is used as an iron source. The growth and the surface modification of Fe3O4 crystalline nucleation happen at the same time. Second, monodispersed Fe3O4 micro/nanospheres were prepared without additional surfactant or external magnetic fields. Third, this method is preferred compared with the conventional organic phase method, as the reaction condition is milder and less pollutant will be produced.
Longer stitch interval in the Krackow stitch for tendon graft fixation leads to poorer biomechanical property
Authors: Hong Chih-Kai , Lin Cheng-Li , Kuan Fa-Chuan , Wang Ping-Hui , Yeh Ming-Long , Su Wei-Ren 
Published: September 2018

Purpose: The purpose of this study was to analyze the effects of different intervals between stitch throws on tendon graft fixation with the Krackow stitch. Methods: Forty-four porcine flexor profundus tendons were randomly divided into four groups of 11 specimens each. The Krackow stitch with various stitch intervals (2.5, 5.0, 7.5, and 10.0 mm) were evaluated, and named the K-2.5, K-5.0, K-7.5, and K-10.0 groups, respectively. A braided nonabsorbable suture was used to complete each suture-tendon construct. All specimens were pretensioned to 100 N for three cycles, cyclically loaded from 50 to 200 N for 200 cycles, and then finally loaded to failure. Elongation after cyclic loading, ultimate load to failure, and the mode of failure were recorded. Results: There were significant differences in elongation after cyclic loading among the K-2.5 (31% ± 5%), K-5.0 (32% ± 4%), K-7.5 (34% ± 5%), and K-10.0 (41% ± 8%) groups ( p = 0.004); the post hoc analysis showed significantly smaller values in the K-2.5 and K-5.0 groups than in the K-10.0 group ( p = 0.002 and 0.003, respectively). The stitch interval was correlated with elongation after cyclic loading ( r = 0.52, p < 0.001). Ultimate loads to failure and cross-sectional area were not significantly different across the four groups. Conclusion: The Krackow stitch with stitch intervals of 2.5 and 5.0 mm had significantly smaller elongation after cyclic loading than with an interval of 10.0 mm in this porcine biomechanical study. The stitch interval was moderately correlated with elongation after cyclic loading.
Congenital pseudoarthrosis of the clavicle: Should we reconsider timing and fixation method?
Authors: Giwnewer Uriel , Rubin Guy , Dohovni Eithan , Rozen Nimrod , Bor Noam 
Published: September 2018

Background: Congenital pseudoarthrosis of the clavicle (CPC) is rare and may require treatment, usually because of an unacceptable appearance or occasionally because of pain in an adolescent patient. Spontaneous union is unknown, and consequently any desired union requires open reduction and bone grafting. Many authors recommend performing the operation at the age of 3–5 years and using different fixation methods. We present our experience with three cases and literature review in an attempt to further elucidate the appropriate timing of the procedure and the fixation method. Methods: This was a retrospective review of three cases presenting with pseudoarthrosis of the clavicle. All cases were treated by curettage of the pseudoarthrosis, with the void filled using full-thickness ileac crest autologous bone graft and bridging plate—one compression and two anatomical, at different ages. We performed a literature review with emphasis on timing of the procedure, fixation method and complications. Results: All patients healed with good callus formation. One patient (5-year-old female treated using a compression plate) experienced overlying skin irritation and underwent removal of the plate. There were no restriction of movement, pain or any other complaint on the final follow-up. We did not find any difference in the operating complexity at different ages, but when a compression plate was used, it had to be removed later due to bulging of the plate. Discussion: No clinical difference was observed between earlier and late operation. Therefore, we suggest performing a curettage of the pseudoarthrosis, gapping the void using autologous bone graft, and using an anatomical bridging plate.
A Systematic Summary of Systematic Reviews on the Topic of the Rotator Cuff
Authors: Jancuska Jeffrey , Matthews John , Miller Tyler , Kluczynski Melissa A. , Bisson Leslie J. 
Published: September 2018

Background: The number of systematic reviews and meta-analyses published on the rotator cuff (RC) has increased markedly. Purpose: To quantify the number of systematic reviews and meta-analyses published on the RC and to provide a qualitative summary of the literature. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic search for all systematic reviews and meta-analyses pertaining to the RC published between January 2007 and September 2017 was performed with PubMed, MEDLINE, and the Cochrane Database of Systematic Reviews. Narrative reviews and non–English language articles were excluded. Results: A total of 1078 articles were found, of which 196 met the inclusion criteria. Included articles were summarized and divided into 15 topics: anatomy and function, histology and genetics, diagnosis, epidemiology, athletes, nonoperative versus operative treatment, surgical repair methods, concomitant conditions and surgical procedures, RC tears after total shoulder arthroplasty, biological augmentation, postoperative rehabilitation, outcomes and complications, patient-reported outcome measures, cost-effectiveness of RC repair, and quality of randomized controlled trials. Conclusion: A qualitative summary of the systematic reviews and meta-analyses published on the RC can provide surgeons with a single source of the most current literature.
Keeping It in the Fairway
Authors: Taylor Michel A. , Lachman James R. , Adams Samuel B. , Nunley James A. , DeOrio James K. 
Published: September 2018

Background: Total ankle arthroplasty (TAA) provides a surgical alternative to tibiotalar arthrodesis when treating end-stage ankle arthritis. TAA preserves range of motion at the tibiotalar joint leading to improved postoperative function. Many patients who undergo TAA wish to maintain a high level of activity, including participation in low-impact sports such as golf. There are several studies in the total hip and total knee arthroplasty literature that have looked at the effect of total joint arthroplasty on golf handicap. We hypothesized that similar to hip and knee arthroplasty research, TAA is likely to result in a postoperative increase in golf handicap. Methods: After obtaining institutional review board approval, we retrospectively identified 60 patients (from 140 consecutive TAAs performed between August 2016 and February 2017) who had undergone TAA, played golf pre- and postoperatively, and had at least 1 year of postoperative follow-up. The average postoperative follow-up for the cohort was 28.1 months. Variables including preoperative and postoperative golf handicaps, swing laterality, age, gender, surgical laterality, implant used, and operating surgeon were recorded. Results: The average preoperative and postoperative handicaps were 19.7 and 17.9, respectively, which did not represent a statistically significant difference ( P = .07). Patients who played 3 or more rounds per week had better preoperative and postoperative handicaps compared to patients who played 2 rounds or less; however, the change in their handicap following TAA and the number of rounds played per week was not affected. There was no association between the change in handicap and the follow-up period, handedness of golf shot, surgical laterality, implant used, or the operating surgeon. Conclusion: Our findings showed that golf handicap was not negatively affected following TAA in this series. Level of Evidence: Level IV, case series.
Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium
Authors: James Kreema , Bhartiya Deepa , Ganguly Ranita , Kaushik Ankita , Gala Kavita , Singh Pushpa , Metkari S. M. 
Published: September 2018

Abstract
Background
Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro. Testicular, ovarian and hematopoietic stem/progenitor cells express receptors for follicle stimulating (FSH) and ovarian hormones and are activated by them to undergo proliferation/differentiation. VSELs exist in mouse uterus and are regulated by physiological dose of estradiol (E) & progesterone (P) during endometrial growth, differentiation and regeneration/remodeling. In the present study, effects of daily administration of E (2 μg/day), P (1 mg/Kg/day) or FSH (5 IU/day) for 7 days on the endometrium and stem/progenitor cells was studied in bilaterally ovariectomized mice.

Results
E treatment resulted in hypertrophy whereas P resulted in hyperplasia and overcrowding of epithelial cells. FSH also directly stimulated the endometrial cells. Nuclear OCT-4A positive VSELs were visualized in ovariectomized (atrophied) endometrium and cytoplasmic OCT-4B positive epithelial, stromal and endothelial cells were observed after treatment. FSH treated uterine tissue showed presence of 4 alternately spliced FSHR isoforms by Western blotting. 3–5 μm VSELs with a surface phenotype of LIN-/CD45-/SCA-1+ were enumerated by flow cytometry and were found to express ER, PR, FSHR1 and FSHR3 by RT-PCR analysis. Differential effects of treatment were observed on pluripotent (Oct4A, Sox2, Nanog), progenitors (Oct-4, Sca-1), primordial germ cells (Stella, Fragilis) and proliferation (Pcna) specific transcripts by qRT-PCR analysis. FSH and P (rather than E) exerted profound, direct stimulatory effects on uterine VSELs. Asymmetric, symmetric divisions and clonal expansion of stem/progenitor cells was confirmed by co-expression of OCT-4 and NUMB.

Conclusions
Results confirm presence of VSELs and their regulation by circulatory hormones in mouse uterus. Stem cell activation was more prominent after P and FSH compared to E treatment. The results question whether epithelial cells proliferation is regulated by paracrine influence of stromal cells or due to direct action of hormones on stem cells. VSELs expressing nuclear OCT-4A are the most primitive and pluripotent stem cells, undergo asymmetric cell division to self-renew and differentiate into epithelial, stromal and endothelial cells with cytoplasmic OCT-4B. Role of follicle stimulating and steroid hormones on the stem cells needs to be studied in various uterine pathologies.
ПОСТРОЕНИЕ ПРОФИЛЯ АБОНЕНТА МОБИЛЬНЫХ СЕТЕЙ НА ОСНОВЕ ОНТОЛОГИЧЕСКОГО ПОДХОДА
Authors: Raevich Aleksey Pavlovich , Dobronets Boris Stanislavovich , Pyataeva Anna Vladimirovna , Raevich Ksenia Vladislavovna 
Published: September 2018

Цель. В связи с увеличением числа абонентов мобильных сетей, используемых абонентами устройств, а также высокой активностью абонентов агрегируемая об атрибутах абонентов информация необходима для выстраивания рекомендательных функций систем телекоммуникационных компаний, проведения маркетинговых инициатив, повышения качества оказываемых услуг, при прогнозировании потребностей и желаний клиентов, а также для многих других функций. Статья посвящена рассмотрение методов, направленных на формализацию предметной области при построении профилей абонентов мобильной связи.Методы. В работе рассматриваются метод формальных понятий, а также модель представления информации на концептуальном уровне в контексте представления знаний об абонентах мобильной связи.Результаты. На основе изучения методов структурирования знаний о предметной области авторами предлагается модель представления качественной и количественной информации об объекте исследования с использованием онтологического подхода.