bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konsep Psikoterapi Sufistik Untuk Pembinaan Kesehatan Mental
Authors: Prafitri Dianing 
Published: August 2019

<p class="06IsiAbstrak">Sufistic psychotherapy that is intended in writing this article is a treatment that nuanced Sufism with the aim to realize a healthy bermental human being. In this study primary sources consisted of literature that directly related to research variables, namely various data about sufistik psychotherapy and mental health. While the secondary sources, namely data related to this research one of them about psychotherapy. This research approach using psychological approach. The psychological approach used as the basis for this research is Sufistic psychotherapy. If faith gave birth to theology of science / kalam, Islam gave birth to the science of shari'ah, then Islam gave birth to the science of akhlaq or tasawuf. His theories are tested in the context of therapeutic psychology, workshops in individual development, individual experimentation by inducing altered state of consciousness eg by worship, meditation, hypnosis, etc., including dhikr. The results of this study, seen that can be used as a cure for mental illness, so as to nurture individuals to achieve mental health.</p><p class="07KatakunciKeywords"> </p>
ANTIMICROBIAL PROPERTIES OF NANO-EMULSION FORMULATED FROM GARLIC, GINGER AND CINNAMON EXTRACTS AGAINST Escherichia coli AND Salmonella typhi
Authors: Hernani Hernani , Dewandari Kun Tanti 
Published: August 2019

<p class="abstrakinggris">Garlic, ginger and cinnamon had been reported for their antimicrobial activities, for instance against <em>Escherichia coli</em> and <em>Salmonella typhi</em>. The present study aimed to test antimicrobial activities of nanoemulsion of the mixture of garlic, ginger and cinnamon. The nanoemulsion was formulated from the mixture of garlic and ginger extracts and cinnamon essential oil at the ratio of 80:10:10 using a high pressure homogenizer at 300 bars for 5 cycles. The nanoemulsion powder was prepared using a spray dryer with the inlet and outlet temperatures of 160–170 °C and 70–80 °C, respectively, and maltodextrin as a filler. The nanoemulsion was tested against <em>E. coli</em> and <em>S. typhi</em>. The particle size of nanoemulsion and powdered formulas were characterized using a scanning electron microscope. The LC<sub>50</sub> values were identified based on the Brine Shrimp Lethality Test. The results showed that quality of the raw materials confirmed the WHO requirements. The particle size of the emulsion ranged from 151 to 306 nm with the polydispersity index of 0.39–0.52. The 10% and 15% active compounds of the nanoemulsion inhibited <em>E. coli</em> and <em>S. thypi</em> with the LC<sub>50</sub> values of 680.15–970.50 ppm and 607.17–903.31 ppm, respectively. The study suggests that the nanoemulsion of a mixture of garlic, ginger and cinnamon extracts could be developed as a food preservative.</p>
Autogenic Erosional Surfaces in Fluvio-deltaic Stratigraphy from Floods, Avulsions, and Backwater Hydrodynamics
Authors: Ganti Vamsi , Lamb Michael P. , Chadwick Austin J. 
Published: August 2019

AbstractErosional surfaces set the architecture of fluvio-deltaic stratigraphy, and they have classically been interpreted in terms of changes in boundary conditions such as climate, tectonics, and base level (allogenic forces). Intrinsic dynamics of sedimentary systems (autogenic dynamics) can also create a rich stratigraphic architecture, and a major knowledge gap exists in parsing the relative roles of autogenic versus allogenic processes. Emerging theoretical and experimental work suggests that backwater hydrodynamics play an important role in driving transient channel incision in river deltas, even those experiencing net aggradation. Here, we identify and quantify two autogenic mechanisms that produce broad erosional surfaces in fluvio-deltaic stratigraphy, namely, floods and avulsions. Using a simple mass-balance model for single-threaded delta channel systems, we show that flood-induced scours begin near the shoreline, and avulsion-induced scours begin at the avulsion site, and both propagate upstream over a distance that scales with the backwater length, bed slope, and bed grain size. We also develop scaling relationships for the maximum scour depths arising from these mechanisms, which are functions of characteristic flow depth and formative flood variability. We test our theoretical predictions using a flume experiment of river delta evolution governed by persistent backwater hydrodynamics under constant relative sea level. Results indicate that autogenic dynamics of backwater-mediated deltas under conditions of constant base level can result in stratigraphic surfaces and shoreline trajectories similar to those often interpreted to represent multiple sea-level cycles. Our work provides a quantitative framework to decouple autogenic and allogenic controls on erosional surfaces preserved in fluvio-deltaic stratigraphy.
A Simplified Gravity Drainage Oil Production Model for Mature Steamdrives
Authors: Closmann P. J. 
Published: August 2019

ABSTRACT
A model has been formulated for estimating the oil production during the mature phase of a steam injection process. This model assumes that complete steam overlay has occurred and that subsequent drainage of oil is accelerated because of the viscosity reduction in the heated oil phase. The predicted oil production history usually shows a rate which declines linearly at early times, depending on the initial oil level in the reservoir, and gradually declines toward zero at long times. The model has been applied to various field cases from the SPE literature. In most cases the model predicts results which are relatively close, usually much better than an order of magnitude, to the available field observations. Adjustment of a parameter such as permeability to take into account specific field behavior is usually sufficient to obtain good agreement in the rate as a function of time for most of the field cases studied. Deviations may be expected from the predicted behavior in those cases where additional mechanisms besides gravity drainage are operative or where there is non-uniform heating of some of the wells in a given field.
Automatic Segmentation of Prostate Magnetic Resonance Imaging Using Generative Adversarial Networks
Authors: Wang Wei , Wang Mingang , Wu Xiaofen , Ding Xie , Cao Xuexiang , Wang Lei , Zhang Jingyi , Wang Peijun 
Published: August 2019

Abstract
Background: Automatic and detailed segmentation of the prostate using magnetic resonance imaging (MRI) plays an essential role in prostate imaging diagnosis. However, the complexity of the prostate gland hampers accurate segmentation from other tissues. Thus, we propose the automatic prostate segmentation method SegDGAN, which is based on a classic generative adversarial network (GAN) model.

Methods: The proposed method comprises a fully convolutional generation network of densely connected blocks and a critic network with multi-scale feature extraction. In these computations, the objective function is optimized using mean absolute error and the Dice coefficient, leading to improved accuracy of segmentation results and correspondence with the ground truth. The common and similar medical image segmentation networks U-Net, fully convolution network, and SegAN were selected for qualitative and quantitative comparisons with SegDGAN using a 220-patient dataset and the publicly available dataset PROMISE12. The commonly used segmentation evaluation metrics Dice similarity coefficient (DSC), volumetric overlap error (VOE), average surface distance (ASD), and Hausdorff distance (HD) were also used to compare the accuracy of segmentation between these methods.

Results: SegDGAN achieved the highest DSC value of 91.66%, the lowest VOE value of 23.47% and the lowest ASD values of 0.46 mm with the clinical dataset. In addition, the highest DCS value of 88.69%, the lowest VOE value of 23.47%, the lowest ASD value of 0.83 mm, and the lowest HD value of 11.40 mm was achieved with the PROMISE12 dataset.

Conclusions: Our experimental results show that the SegDGAN model outperforms other segmentation methods

Keywords: Automatic segmentation, Generative adversarial networks, Magnetic resonance imaging, Prostate
Genetic Regulatory Networks for Salt-Alkali Stress in Gossypium hirsutum With Differing Morphological Characteristics
Authors: Xu Yanchao , Magwanga Richard , Yang Xiu , Jin Dingsha , Cai Xiaoyan , Hou Yuqing , Wei Yangyang , Zhou Zhongli , Wang Kunbo , Liu Fang 
Published: August 2019

Abstract
Background Cotton grows in altering environments that are often unfavorable or stressful for its growth and development. Consequently, the plant must cope with abiotic stresses such as soil salinity, drought, and excessive temperatures. Alkali-salt stress response remains a cumbersome biological process and is regulated via a multifaceted transcriptional regulatory network in cotton Results To discover the molecular mechanisms of alkali-salt stress response in cotton, a comprehensive transcriptome analysis was carried out after alkali-salt stress treatment in three accessions of Gossypium hirsutum with contrasting phenotype. Expression level analysis proved that alkali-salt stress response presented significant stage-specific and tissue-specific. GO enrichment analysis typically suggested that signal transduction process involved in salt-alkali stress response at SS3 and SS12 stages in leaf; carbohydrate metabolic process and oxidation-reduction process involved in SS48 stages in leaf; the oxidation-reduction process involved at all three phases in the root. The Co-expression analysis suggested a potential GhSOS3/GhCBL10-SOS2 network was involved in salt-alkali stress response. Furthermore, Salt-alkali sensitivity was increased in GhSOS3 and GhCBL10 Virus-induced Gene Silencing (VIGS) plants. Conclusion The findings may facilitate to elucidate the underlying mechanisms of alkali-salt stress response and provide an available resource to scrutinize the role of candidate genes and signaling pathway governing alkali-salt stress response
A systematic review of parent based programs to prevent or reduce alcohol consumption in adolescents
Authors: Hurley Erin , Dietrich Timo , Rundle-Thiele Sharyn 
Published: August 2019

Abstract
Background. Adolescent alcohol consumption is an issue of ongoing concern and programs targeting parents have been identified as an important component in minimizing and preventing alcohol related harm in adolescents. This paper aims to evaluate existing parent based alcohol education programs with a focus on understanding parent specific outcomes; the level of theory application and the extent of stakeholder involvement in program design.
Method. A total of seven databases were searched to identify relevant studies published between January 2000 and November 2018. Studies were included if they evaluated school based alcohol education programs that included a parent component and detailed outcome measures associated with parent data.
Results. In total 15 studies qualified for assessment, detailing 11 individual parent programs. Of these, nine programs demonstrated positive effects in at least one parent reported outcome measure. Stakeholder engagement during the design of programs was lacking with the majority of programs. One third of the programs did not report theory use and when theory was used reporting was weak with one program informed by theory, two programs applying theory and four testing theory.
Conclusion. Future studies are recommended to further enhance the effectiveness of parental programs. Given stakeholder involvement can increase levels of engagement, increasing levels of stakeholder involvement in the design of parental programs is recommended to extend parental participation in programs developed. Inclusion of theory in program design and evaluation will further extend understanding of the mechanisms leading to change.
Purification of the recombinant green fluorescent protein from tobacco plants using alcohol/salt aqueous two-phase system
Authors: Dong Jie , Ding Xiangzhen , Wang Sheng 
Published: August 2019

Abstract
Background The green fluorescent protein (GFP) has been regarded as a valuable tool and widely applied as a biomarker in medical applications and diagnostics. A cost-efficient upstream expression system and an inexpensive downstream purification process will meet the demands of the GFP protein with high-purity. Results The recombinant GFP was transiently expressed in an active form in agoinoculated N. benthamiana leaves by using Tobacco mosaic virus (TMV) RNA-based overexpression vector (TRBO). The yield of recombinant GFP was up to ~60% of total soluble proteins (TSPs). Purification of recombinant GFP from the clarified lysate of N. benthaniana leaves was achieved by using an alcohol/salt aqueous two-phase system (ATPS) and following with a further hydrophobic interaction chromatography (HIC). The purification process takes only ~4 h and can recover 34.1% of the protein. The purity of purified GFP was more than 95% and there were no any changes in its spectroscopic characteristics. Conclusions The strategy described here combines the advantages of both the economy and efficiency of plant virus-based expression platform and the simplicity and rapidity of environmentally friendly alcohol/salt ATPS. It has a considerable potential for the development of a cost-efficient alternative for production of recombinant GFP.
Acute changes in the colonic microbiota are associated with large intestinal forms of surgical colic.
Authors: Salem Shebl Ebrahim , Maddox Thomas W , Antczak Philipp , Ketley Julian M , Williams Nicola J , Archer Debra C 
Published: August 2019

Abstract
Abstract
Background
Horses that undergo surgery for treatment of primary large colon disease have been reported to be at increased risk of developing recurrent colic episodes postoperatively. The reasons for this are currently unknown. The aim of the current study was to characterise the faecal microbiota of horses with colic signs associated with primary large colon lesions treated surgically and to compare the composition of their faecal microbiota to that of a control group of horses undergoing emergency orthopaedic treatment. Faecal samples were collected from horses in both groups on admission to hospital, during hospitalisation and following discharge from hospital for a total duration of 12 weeks. Additionally, colonic content samples were collected from surgical colic patients if pelvic flexure enterotomy was performed during laparotomy. A total of 12 samples were collected per horse. DNA was extracted from samples using a commercial kit. Amplicon mixtures were created by PCR amplification of the V1 – V2 regions of the bacterial 16S rRNA genes and submitted for sequencing using the Ion Torrent PGM next-generation sequencing system. Multivariate data analysis was used to characterise the faecal microbiota and to investigate differences between groups.
Results
Reduced species richness was evident in the colonic samples of the colic group compared to concurrent sampling of the faeces. Alpha and beta diversity differed significantly between the two sets of samples with 304 significantly differentially abundant OTUs identified. Only 46 OTUs varied significantly between the colic and control group. There were no significant differences in alpha and beta diversity of faecal microbiota between colic and control horses at admission.
Conclusions
The results of the current study suggest that faecal samples collected at hospital admission in colic cases may not accurately represent changes in upper gut microbiota in horses with colic due to large colon disease.
The Role of F11R in Pancreatic Cancer Malignancy and Its Clinical Implication as a Therapeutic Target
Authors: zhang Haidi , Zhao Chunyan , Hu Xianhua , He Shuai , Yu Jinchuan , Zhu Huiling , Mu Bo 
Published: August 2019

Abstract
Abstract
Background
The F11 receptor belongs to the immunoglobulin superfamily and is expressed in epithelial and endothelial cells. F11R mediates the formation of tight junctions between the epithelium and endothelium, and participates in the invasion and metastasis of tumor cells. We have previously shown that the F11R gene is closely related to KRas (P= 0.76), a known therapeutic target for pancreatic cancer (PCa). In recent years, it has been found that F11R is expressed in different tumors and has biological effects.However, according to different tumor cases, different cell lines and experimental conditions, the regulatory results and mechanisms of F11R on tumor are different, even contradictory,and the expression, clinical significance and biological mechanism of F11R in tumor tissues have not been reported in detail.
Results
To investigate the role of F11R in carcinogenesis of PCa and the potential of F11R as a therapies target for PCa, we silenced F11R (-/-) in the PCa cell line PANC-1 (known to express high levels of KRas) using lentiviral approaches.We found that F11R silencing led to decreased cell proliferation, a loss of cell invasiveness, reduced colony forming ability, cell cycle arrest in G1 phase, cells apoptosis enhanced, and ros enhanced. In vitro data showed that inhibition of F11R decreased proliferation and invasiveness of cancer cells.The present results suggest that F11R may be a promising therapeutic target for PCa.
Conclusions
This study used bioinformatics combined with gene chip data to find the gene F11R, which is closely related to KRAS gene, and we used lentivirus to package shRNA plasmid to interfere with the gene F11R in pancreatic cancer panc-1 cells. A series of biobehavioral studies indicated the biobehavioral function and malignancy of panc-1 in pancreatic cancer cells with negative regulation of F11R gene.Based on this, we need to continue to clarify the expression of F11R gene in clinical case samples to determine whether F11R gene can be a new therapeutic target for pancreatic cancer.
Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment
Authors: Jin Mei , Zhao Qin Feng , Ni Ping , Piao Jun , Piao Ai Jing 
Published: August 2019

Abstract
Abstract : (Background)Liaoning cashmere goat cashmere has high economic value FGF5 is an important factor regulating its growth. The role of long non-coding RNA (LncRNA) in the mammalian villus growth cycle has still not been studied in detail.(Results)This study investigated how LncRNA mediates the effects of FGF5 on the growth of Liaoning cashmere goats. We screened for LncRNA related to hair follicle development and villus growth by RNA-seq sequencing. GO and pathway analysis determined that the optimal treatment conditions for FGF5 drugs are 10 -4 g/L for 72h (F4_72h). The expression levels of CBS, CTH, keratin gene K26, KAP11.1 were studied when overexpressing and interfering with LncRNA. (Conclusions)To our knowledge, this is the first study on how LncRNA regulates villi growth by regulating target genes and keratin genes in the amino acid metabolic pathway; it is also the first to open a new research direction for studying the mechanism of FGF5 in regulating hair follicle development and villus growth.
Base-pair Ambiguity and the Kinetics of RNA Folding
Authors: Zhou Guangyao , Loper Jackson , Geman Stuart 
Published: August 2019

Abstract
Background : A folding RNA molecule encounters multiple opportunities to form non-native yet energetically favorable pairings of nucleotide sequences. Given this forbidding free-energy landscape, mechanisms have evolved that contribute to a directed and efficient folding process, including catalytic proteins and error-detecting chaperones. Among structural RNA molecules we make a distinction between "bound" molecules, which are active as part of ribonucleoprotein (RNP) complexes, and "unbound," with physiological functions performed without necessarily being bound in RNP complexes. We hypothesized that unbound molecules, lacking the partnering structure of a protein, would be more vulnerable than bound molecules to kinetic traps that compete with native stem structures. We defined an "ambiguity index"---a normalized function of the primary and secondary structure of an individual molecule that measures the number of kinetic traps available to nucleotide sequences that are paired in the native structure, presuming that unbound molecules would have lower indexes. The ambiguity index depends on the purported secondary structure, and was computed under both the comparative ("gold standard") and an equilibrium-based prediction which approximates the minimum free energy (MFE) structure. Arguing that kinetically accessible metastable structures might be more biologically relevant than thermodynamic equilibrium structures, we also hypothesized that MFE-derived ambiguities would be less effective in separating bound and unbound molecules.
Results : We have introduced an intuitive and easily computed function of primary and secondary structures that measures the availability of complementary sequences that could disrupt the formation of native stems on a given molecule---an ambiguity index. Using comparative secondary structures, the ambiguity index is systematically smaller among unbound than bound molecules, as expected. Furthermore, the effect is lost when the presumably more accurate comparative structure is replaced instead by the MFE structure.
Conclusions : A statistical analysis of the relationship between the primary and secondary structures of non-coding RNA molecules suggests that stem-disrupting kinetic traps are substantially less prevalent in molecules not participating in RNP complexes. In that this distinction is apparent under the comparative but not the MFE secondary structure, the results highlight a possible deficiency in structure predictions when based upon assumptions of thermodynamic equilibrium.
Identification of Dissociation Factors in Pancreatic Cancer using a Mass Spectrometry-Based Proteomic Approach
Authors: Liu Peng , Kong Lingming , Liang Keke , Wu Yunhao , Jin Haoyi , Song Bing , Tan Xiaodong 
Published: August 2019

Abstract
Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. In this study, different protein pretreatment methods were used to analyze the secretome, furthermore to identify dissociation factors in pancreatic cancer. Pancreatic cancer cells were cultured in serum-containing or serum-free medium, and the corresponding supernatants were extracted as samples. Subsequently, the above samples were separated by size exclusion chromatography (SEC), and peptide segments were identified by LC-MS/MS. The final results were identified via the hamster secreted protein database and a public database. Although the number of identified proteins in the serum-free medium group was high, the real secretion of proteins in pancreatic cancer cells was changed. There were six significant secreted proteins in the serum-containing medium group. Survival analysis via the TCGA database suggested that patients with higher expression levels of YWHAG showed a worse overall survival rate than those with lower YWHAG expression. YWHAG could be used as a prognostic indicator for pancreatic cancer. Finally, the results in the serum-containing medium group were more similar to the real secretome of pancreatic cancer cells, and the results might be used to identify biomarkers in liquid biopsy.