bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic evaluation plan of a randomised controlled trial of intra-nodular injection of anti-TNF and placebo among patients with early Dupuytren’s disease: Repurposing Anti-TNF for Treating Dupuytren’s Disease (RIDD)
Authors: Png May Ee , Dritsaki Melina , Gray Alastair , Pinedo-Villanueva Rafael , Rivero-Arias Oliver , Nanchahal Jagdeep 
Published: February 2019

Dupuytren’s disease (DD) is a common fibroproliferative condition of the palmar and digital fascia of the hand; however, there is currently no approved treatment for early stage DD. The objective of this paper is to describe the methods applied to assess the cost-effectiveness of adalimumab injections compared to usual care for controlling the progression of early stage DD in the Repurposing Anti-TNF for Treating Dupuytren’s Disease (RIDD) trial. Measure of effectiveness and resource use will be obtained from a randomised clinical trial, carried out in three healthcare centres, and recruiting a minimum of 138 patients aged 18 years and above with a diagnosis of early stage DD. Resource use and utility measures (quality-adjusted life years) will be collected at 3, 6, 9, 12 (primary outcome endpoint) and 18 months post-randomisation. A within-trial cost-utility analysis (CUA) will be conducted at 12 months and if the intervention is effective, a decision analytic model will be applied to estimate the lifetime effectiveness and costs. The analysis will be performed from a health system (National Health Service and personal social services) perspective. Sensitivity analysis will be conducted to assess the robustness of the results. RIDD is the first randomised controlled trial with an economic evaluation conducted among patients with early stage DD. The protocol described here records our intent to conduct both a within-trial CUA alongside the RIDD study and a lifetime CUA using decision-analytic modelling.
A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency
Authors: Pikkarainen Sampsa , Martelius Timi , Ristimäki Ari , Siitonen Sanna , Seppänen Mikko R.J. , Färkkilä Martti 
Published: February 2019

OBJECTIVES:
Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

METHODS:
Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Data on endoscopies, histology, and laboratory studies were retrieved from patient files.

RESULTS:
Most common referral indications were diarrhea and/or weight loss (47%–67%). Patients with probable CVID had higher fecal calprotectin and α1-antitrypsin and lower blood vitamin B12 than patients with possible CVID. Gastroscopy and colonoscopy were done to 71 (67%) and 63 (59%) patients with probable CVID, respectively. Endoscopies showed that 15% of them had chronic active gastritis and 17% atrophic gastritis and 3% had gastric adenocarcinoma. A celiac sprue-like condition was found in 7 patients (10%), of whom 3 responded to a gluten-free diet. Colonoscopies demonstrated unspecific colitis (14%), ulcerative colitis (8%), microscopic colitis (10%), and Crohn's disease (2%). Colonic polyps were noted in 30% of patients, and 3% had lower GI malignancies. Thirty-five patients with CVID had bacterial or parasitic gastroenteritis; chronic norovirus was detected in 4 patients with probable CVID. Patients with GI inflammation had higher levels of fecal calprotectin and blood CD8+ T lymphocytes but lower counts of CD19+CD27+ memory B cells and/or CD19+ B cells. Immunophenotype with low B-cell counts was associated with higher fecal calprotectin levels.

DISCUSSION:
Patients with CVID had a high prevalence of GI manifestations and infections of the GI tract. GI inflammation was associated with a distinct immunophenotype and elevated fecal calprotectin.
The effect of Lego Mindstorm projects on problem solving skills and scientific creativity of teacher candidate<p>Öğretmen adaylarının problem çözme becerilerine ve bilimsel yaratıcılıklarına Lego Mindstorm projelerinin etkisi
Authors: Avcı Berkan , Şahin Fatma 
Published: February 2019

In this study; the effects of Lego Mindstorms projects on problem solving skills and scientific creativity of teacher candidates were. The study group consisted of 20 pre-service science teachers. The data were collected quantitatively and qualitatively. Problem solving and scientific creativity test were used as quantitative data collection instruments. , Teacher Participant Interview was used as qualitative data collection tool. The practice with teacher candidates lasted 9 weeks. In this process, pre-service teachers learned the software. Then, these teacher candidates were presented with the science problems appropriate to different grade levels and produced solutions to these problems with Lego EV3 Education sets.Results of the study, the participating teacher candidates identified Lego Ev3 Education sets as creative (25.6%), functional (18.7%), educational (20.9%), developmental (20.9%) and informative (13.9%). As a result of the projects carried out with the Lego Ev3 education sets, the problem solving skills and scientific creativity of the prospective teachers developed.Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetBu çalışmada; Lego Mindstorms projelerinin öğretmen adaylarının problem çözme becerilerine ve bilimsel yaratıcılıklarına etkisi incelenmiştir. Araştırmanın çalışma grubunu Fen Bilgisi 3.sınıf öğrencisi 20 öğretmen adayı oluşturmuştur. Araştırmada nicel ve nitel veriler toplanmıştır. Nicel veri toplama araçları olarak problem çözme envanteri ve bilimsel yaratıcılık testi kullanılmıştır. Nitel veri toplama aracı olarak da öğretmen görüş anketi kullanılmıştır. Araştırmanın uygulama süreci 9 hafta sürmüştür. Bu süreçte önce öğretmen adayları yazılımı öğrenmiştir. Sonra bu öğretmen adaylarına farklı sınıf düzeylerine uygun fen problemleri sunulmuş ve bu problemlere Lego EV3 Education setleri ile çözüm üretmişlerdir.Çalışmanın sonuçları, araştırmaya katılan öğretmen adaylarının Lego Ev3 Education setlerini: yaratıcı (%25.6), işlevsel (%18.7), eğitimde uygulanabilir (%20.9), gelişimsel (%20.9) ve bilgiyi uygulayabilir (%13.9) olarak tanımladıklarını ortaya çıkarmıştır. Lego Ev3 education setleri ile yapılan projeler sonucunda öğretmen adaylarının problem çözme becerileri ve bilimsel yaratıcılıkları gelişmiştir.
Software complex for modeling and optimization of program implementation on parallel calculation systems
Authors: Bakanov Valery 
Published: February 2019

Abstract
The paper considers the problem of developing rational methods for the creation of a framework (a plan, execution timetable) of parallel programs for real parallel computing systems. To solve this problem, a software environment (software stand) has been developed that allows implementing different strategies for building a framework for parallel programs and assessing the quality of these strategies. The built-in script Lua programming language is used to increase the flexibility of modeling and optimization capabilities. Results of applying some of the proposed strategies for constructing rational plans for parallel programming are outlined.
Emotion-focused training for emotion coaching – an intervention to reduce self-criticism
Authors: Halamová Júlia , Kanovský Martin 
Published: February 2019

AbstractEmotion-Focused Training for Emotion Coaching (EFT-EC) is based on Emotion-focused Therapy findings and was developed to help participants deepen their emotional skills. The goal was to examine the efficacy of a 12-week EFT-EC group program the level of emotion intelligence, self-compassion and self-criticism in a student population. A quasi-experiment with no control group was conducted with pre- and post-measurements using The Self-compassion scale (SCS), the Forms of Self-Criticising/Attacking & Self-Reassuring Scale (FSCRS), and the Trait Emotional Intelligence Questionnaire – short form (TEIQue-SF). The EFT-EC participants were128 students. The EFT-EC intervention had a significant effect on self-criticism and self-control latent scores as reported at post-measurement. The structural equation model with latent variables was not an adequate fit for the rest of the subscales. These results are promising and suggest that interventions intended to enhance emotion skills can also reduce self-criticism even when not directly addressing it.
Prospectives for the Use of Li-Ion Batteries in Hybrid Stand-Alone Power Sources
Authors: Khantimerov Sergey , Fatykhov Ranis , Suleimanov Nail 
Published: February 2019

Abstract
In this paper, the possibility of using lithium-ion batteries in hybrid stand-alone power sources is considered. The article gives a comparative analysis of the energy and performance characteristics, the service life of lead-acid and lithium-ion batteries. It is shown that the longer service life and the specific energy density, the absence of the need for constant monitoring of the main parameters and the ability to preserve the original capacity at increased discharge currents, open the possibility of using lithium-ion batteries in hybrid stand-alone power sources.
Effect of wood flour and naphthenic oil on morphology, rheological and mechanical properties of EPDM/PP/AL composite
Authors: Gou Rui , Guo Minghui 
Published: February 2019

Abstract
Thermoplastic elastomer (TPE), made from ethylene propylene diene monomer (EPDM) and polypropylene (PP) base on reactive blending, has an excellent processing performance and characteristics and a wide range of applications. In this paper, EPDM, PP and ammonium lignosulfonate (AL) were selected as raw materials, wood flour (WF) of poplar tree was used as filler, naphthenic oil was used as plasticizer, DCP vulcanization system with dynamic vulcanization was carried, to make a new kind of composite material. This research studied the influences of wood flour and naphthenic oil content on the microstructure, mechanical properties and rheological properties of the composite material. The result showed: the content of wood flour and naphthenic oil has big impact on composite material. With the increase of the wood flour content, the mechanical properties are increased firstly and then decreased. The viscosity and modulus of the composite is improved with the increase of wood flour. With of the increase of the amount of naphthenic oil, the mechanical properties, viscosity and modulus of the composites decreased. When the content of wood flour is between 30–60 parts and the content of naphthenic oil is less than 20, the EPDM/PP/AL composite is suitable for using as the core layer elastic material of composite floor.
Prenatal Detection and Postnatal Verification of Unusual Intracardiac Total Anomolous Pulmonary Venous Connection (Tapvc) in Complex Heart Defect with Dextrocardia - Case Report
Authors: Krasoń Aneta , Płużańska Joanna , Łukaszewski Maciej , Moll Jadwiga , Respondek-Liberska Maria 
Published: February 2019

Abstract
Prenatal diagnosis of total anomolous pulmonary venous connection (intracardiac) was diagnosed in fetus with dextrocardia and complex heart defect, which allowed fetal echocardiography monitoring, planning the time and place for delivery as well as early cardiac surgery. The differences between prenatal and postnatal evaluations were underlined. Despite life treathening condition neonate was asymptomatic without any heart murmur for the first 3 days after delivery.
Application of quercetin in neurological disorders: from nutrition to nanomedicine
Authors: Amanzadeh Elnaz , Esmaeili Abolghasem , Rahgozar Soheila , Nourbakhshnia Maryam 
Published: February 2019

Abstract
Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. The antioxidant potential of quercetin has been studied from subcellular compartments, that is, mitochondria to tissue levels in the brain. The neurodegeneration process initiates alongside aging of the neurons. It appears in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and others, which leads to Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and other diseases. So far, no specific treatment has been identified for these diseases. Despite common treatments that help to prevent the development of disease, the condition of patients with progressive neurodegenerative diseases usually do not completely improve. Currently, the use of flavonoids, especially quercetin for the treatment of neurodegenerative diseases, has been expanded in animal models. It has also been used to treat animal models of neurodegenerative diseases. In addition, improvements in behavioral levels, as well as in cellular and molecular levels, decreased activity of antioxidant and apoptotic proteins, and increased levels of antiapoptotic proteins have been observed. Low bioavailability of quercetin has also led researchers to construct various quercetin-involved nanoparticles. The treatment of animal models of neurodegeneration using quercetin-involved nanoparticles has shown that improvements are observed in shorter periods and with use of lower concentrations. Indeed, intranasal administration of quercetin-involved nanoparticles, constructing superparamagnetic nanoparticles, and combinational treatment using nanoparticles such as quercetin and other drugs are suggested for future studies.
Hückel Molecular Orbital Quantities of {X,Y}-Cyclacene Graphs Under Next-Nearest-Neighbour Approximations in Analytical Forms
Authors: Ghosh Tapanendu , Mondal Swapnadeep , Mondal Sukanya , Mandal Bholanath 
Published: February 2019

Abstract
Hückel molecular orbital (HMO) quantities, viz., electron densities, charge densities, bond orders, free valences, total π-electron energies and highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO–LUMO) or band gaps of {X,Y}-cyclacene graphs under next-nearest-neighbour (nnn) approximations are expressed in analytical forms within a certain range of nnn approximation parameter (m). The critical values of m for {X,Y}-cyclacenes with varying X (=C, N, B) and Y (=C, N, B) are calculated. For {X,X}-cyclacenes with a π-electron on each atom, all HMO quantities except total π-electron energies for a given value of m are found to be independent of X. The cyclic dimer (CD) is constructed in obtaining the eigenvalues corresponding to the singular points of the density of states (DOS) of such {X,Y}-cyclacene. Although the HOMO–LUMO gap of the CD differs from that of the cyclacene with a large number of repeating units (i.e. n ⟶ ∞) but becomes the same for m = 0. The analytical expressions can be used for facile computer programming in obtaining the HMO quantities. Such nnn interaction approximations actually release, to some extent, the strain that results in due to the geometrical structures of such cyclacenes, which is evident from the plots of strain energy per segment vs. contribution of such interactions on the total π-electron energy, where the slopes decrease with an increase in m. The vertical absorption energy difference for singlet-triplet states bears excellent linear correlation with the HOMO–LUMO gaps for a certain m value (m = 0.3) in the case of an even n, but for an odd n, such energy difference remains invariant.
Performance Profiling of Female Youth Netball Players
Authors: McKenzie Chloe R. , Whatman Chris , Brughelli Matt 
Published: February 2019

Abstract
McKenzie, CR, Whatman, C, and Brughelli, M. Performance profiling of female youth netball players. J Strength Cond Res 34(11): 3275–3283, 2020—The purpose of this study was to investigate the physical performance characteristics of New Zealand secondary school netball players to provide a physical performance profile and determine whether there are differences between playing grade and playing positions for this group. A total of 102 female netball players (mean ± SD: age 13.3 ± 0.50 years, height 166.95 ± 5.72 cm, and body mass 60.94 ± 12.80 kg) participated in this study. Measurements included anthropometry, horizontal and vertical jump performance, balance, core strength, change-of-direction speed, and split sprint times. Magnitude-based inferences were used to determine differences in all measures. Grade 1 players jumped further and higher (effect size [ES] = 0.41–1.37) and ran faster with small to moderate differences. They demonstrated faster change-of-direction speed (ES = −0.73 to −1.31), greater core strength (ES = 0.28–1.17), and a faster time-to-stabilization (ES = −0.69). Grade 2 circle players jumped further (ES = −0.29), compared with noncircle players who jumped higher (ES = 0.35). Noncircle players had faster sprint and change-of-direction speed (ES = −0.33 to −0.55) and measures of balance (ES = −0.47 to 0.55). Grade 1 circle players were found to be faster over 20 m (ES = 0.75). The results of this study showed differences in the physical performance capabilities between youth netball players competing in different grades, as well as differences between playing positions. These findings have provided a physical performance profile of female youth netball players in New Zealand, suggesting that physical performance measures could be used for position-specific training and talent identification and selection.
Subjective Wellness, Acute: Chronic Workloads, and Injury Risk in College Football
Authors: Sampson John A. , Murray Andrew , Williams Sean , Sullivan Adam , Fullagar Hugh H. K. 
Published: February 2019

Abstract
Sampson, JA, Murray, A, Williams, S, Sullivan, A, and Fullagar, HHK. Subjective wellness, acute: chronic workloads and injury risk in college football. J Strength Cond Res 33(12): 3367–3373, 2019—Acute:chronic workload ratios (ACWRs) are associated with injury risk across team sports. In this study, one season of workload and wellness data from 42 collegiate football players were retrospectively analyzed. Daily 7:21 day exponentially weighted moving average (EWMA) ACWRs were calculated, and z-score fluctuations (“normal,” “better,” and “worse”) in sleep, soreness, energy, and overall wellness were assessed relative to the previous day ACWRs and considered as an interactive effect on the risk of noncontact injury within 0–3 days. Fifty-five noncontact injuries were observed, and injury risks were very likely higher when ACWRs were 2 SDs above (relative risk [RR]: 3.05, 90% confidence interval [CI]: 1.14–8.16) and below (RR: 2.49, 90% CI: 1.11–5.58) the mean. A high ACWR was trivially associated (p < 0.05) with “worse” wellness (r = −0.06, CI: −0.10 to −0.02), muscle soreness (r = −0.07, CI: −0.11 to −0.03), and energy (r = −0.05, CI: −0.09 to −0.01). Feelings of “better” overall wellness and muscle soreness with collectively high EWMA ACWRs displayed likely higher injury risks compared with “normal” (RR: 1.52, 90% CI: 0.91 to 2.54; RR: 1.64, 90% CI: 1.10–2.47) and likely or very likely (RR: 2.36, 90% CI: 0.83 to 674; RR: 2.78, 90% CI: 1.21–6.38) compared with “worse” wellness and soreness, respectively. High EWMA ACWRs increased injury risk and negatively impacted wellness. However, athletes reporting “better” wellness, driven by “better” muscle soreness presented with the highest injury risk when high EWMA ACWRs were observed. This suggests that practitioners are responsive to, and/or athletes are able to self-modulate workload activities.
Principal Component Analysis of the Associations Between Kinetic Variables in Cutting and Jumping, and Cutting Performance Outcome
Authors: Welch Neil , Richter Chris , Moran Kieran , Franklyn-Miller Andy 
Published: February 2019

Abstract
Welch, N, Richter, C, Moran, K, and Franklyn-Miller, A. Principal component analysis of the associations between kinetic variables in cutting and jumping, and cutting performance outcome. J Strength Cond Res 35(7): 1848–1855, 2021—The primary aim of this study was to determine which features within the ground reaction force (GRF) trace during cutting are related to performance outcome in different angled cuts. The secondary aim was to understand the relationship between GRF features in a series of maximum strength, explosive strength, and reactive strength tests, and cutting performance outcome. Twenty-five male intercounty Gaelic football players (23.5 ± 4.2 years, 183 ± 6 cm, and 83 ± 6.9 kg) participated in the study. Subjects completed 110 and 45° cutting tasks, single leg squat jumps, drop landings, drop jumps, and isometric midthigh pulls. A principal component (PC) analysis and simulation approach were applied to the data and correlations between PCs and cutting performance outcome measured. Lower vertical to horizontal impulse ratios (r = −0.70 to −0.46) in both cuts and greater forces over the first 50 ms of ground contact (r = −0.44) in the 110° cut correlated with enhanced cutting performance outcomes. Greater reactive strength index and height in the drop jump (r = −0.51 and −0.54) and greater impulses over the first 25 ms of ground contact in the drop landing (r = 0.49 and 0.70) correlated with enhanced cutting performance outcomes. These results highlight the importance of greater horizontal and rapid force production in cutting and greater reactive strength qualities to enhance cutting performance.
Training Experience and Maturational, Morphological, and Fitness Attributes as Individual Performance Predictors in Male and Female Under-14 Portuguese Elite Basketball Players
Authors: Ramos Sérgio , Volossovitch Anna , Ferreira António P. , Fragoso Isabel , Massuça Luís M. 
Published: February 2019

Abstract
Ramos, S, Volossovitch, A, Ferreira, AP, Fragoso, I, and Massuça, LM. Training experience and maturational, morphological, and fitness attributes as individual performance predictors in male and female under-14 Portuguese elite basketball players. J Strength Cond Res 35(7): 2025–2032, 2021—The association of the biological maturation, morphological attributes, and fitness attributes of 13- to 14-year-old players selected to regional basketball teams, which participated in the Portuguese Festival of Youth Basketball, was analyzed in the study. A total of 416 under-14 Portuguese elite basketball players (male, n = 224; female, n = 192) were evaluated in this cross-sectional study. Maturational parameters (maturity offset and predicted age at peak height velocity), morphological attributes (body mass, stature, skinfolds, and lengths), and fitness (sprint, agility, jump, and upper-body strength) attributes were measured. In addition, basketball game performance was assessed using technical statistics (rebounds and point averages) and the performance index rating (PIR). Correlation analyses indicated that male players with better PIR/minute were taller, had a longer hand span, had more free-fat mass, and demonstrated better results in all jumping tests, upper-body strength tests, 20-m speed test, and agility T-test. Female players with better PIR/minute were significantly older, more matured, heavier, taller, and had longer arm and hand span. They also demonstrated better results in jumping tests, medicine ball throw, had greater practice experience, and were subjected to higher training loads. Multiple regression analysis showed that combined stature, handgrip strength, agility, and countermovement jump (with arm swing power) can be considered strong predictors of PIR per time played for male players. The prediction model for female players indicated that maturity offset, practice experience, and agility were the strongest predictors of basketball performance. In conclusion, the results of this study indicate that around puberty, physical fitness attributes of elite basketball players of both sexes are associated with game performance parameters. Two regression models have been estimated to predict the performance of youth basketball players of both genders.