bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Autologous Cell‐Derived Exosomes to Boost Melanoma‐Targeted Radio‐Immunotherapy by Cascade cGAS‐STING Pathway Activation
Authors: Zhang Fangming , Zhang Ziyao , Yang Wanting , Peng Zhuyuan , Sun Juntao , Li Guofeng , Wei Yen , Wang Xing , Zhao Lingyun , Xie Wensheng 
Published: November 2024

AbstractRadio‐immunotherapy has offered emerging opportunities to treat invasive melanoma due to its immunostimulatory performances to activate antitumor immune responses. However, the immunosuppressive microenvironment and insufficient response rate significantly limit the practical efficacy. This study presents an autologous cell‐derived exosomes (Exo)‐engineered nanoagonist (MnExo@cGAMP) containing with metalloimmunotherapeutic agent (Mn2+ ions) and nucleotidyltransferase (2′,3′‐cGAMP, a STING agonist) for boosting melanoma‐targeted radio‐immunotherapy by cascade cGAS‐STING pathway activation. The MnExo@cGAMP can efficiently accumulate in tumor cells due to the autologous targeting performance. Once internalized by tumor cells, the released Mn2+ ions will enhance stimulator of interferon gene (STING) binding and sensitize cyclic GMP‐AMP (cGAS) to radiotherapy‐induced double‐straned DNA (dsNDA), resulting in amplification of cGAS‐STING pathway activation together with X‐ray irradiation. Meanwhile, loaded 2′,3′‐cGAMP can directly augment pathway activity acting as a secondary messenger. These cascade activations of cGAS‐STING pathway trigger the overexpression of type I interferon, promote dendritic cells (DCs) maturation, antigen presentation, and increase CD8+ T cell activation, resulting effective radio‐immunotherapeutic outcome by overcoming immune‐suppression in melanoma. This study demonstrates a targeted therapeutic modality involving metalloimmunotherapy and agonist for efficient melanoma radio‐immunotherapy by cascade cGAS‐STING pathway activation.
A Bifunctional Iron‐Nickel Oxygen Reduction/Oxygen Evolution Catalyst for High‐Performance Rechargeable Zinc–Air Batteries
Authors: Chen Zhengfan , Cheng Weiyi , Cao Kecheng , Jin Meng , Rahali Sarra , Chala Soressa Abera , Ebrahimi Elnaz , Ma Nana , Liu Rongji , Lakshmanan Keseven , Chang Chia‐Yu , Cheung Chun‐Chi , Luo Haojian , Wang Yongkang , Hwang Bing Joe , Streb Carsten 
Published: November 2024

AbstractEfficient and robust electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are crucial for fuel cells, metal‐air batteries, and other energy technologies. Here, a highly stable, efficient bifunctional OER/ORR electrocatalyst (FeNi‐NC@MWCNTs) is reported and demonstrated its integration and robust performance in an aqueous Zinc–air battery (ZAB). The catalyst is based on neighboring iron/nickel sites (FeNiN6) which are atomically dispersed on porous nitrogen‐doped carbon particles. The particles are wrapped in electrically conductive multi‐walled carbon nanotubes for enhanced electrical conductivity. Electrocatalytic analyses show high OER and ORR performance (OER/ORR voltage difference = 0.69 V). Catalyst integration in a ZAB results in excellent performance metrics, including an open circuit voltage of 1.44 V, a specific capacity of 782 mAh g−1 (at j = 15 mA cm−2), a peak power density of 218 mW cm−2 (at j = 260 mA cm−2) and long‐term durability over 600 charge/discharge cycles. Combined experimental and theoretical (density functional theory) analyses provide an in‐depth understanding of the physical and electronic structure of the catalyst and the role of the FeNi dual atom reaction site. The study therefore provides critical insights into the structure and reactivity of high‐performance bifunctional OER/ORR catalysts based on atomically dispersed non‐critical metals.
Strategic Patterns to Foster the Evolution of Emerging Software Ecosystems
Authors: Belo Ítalo , Alves Carina 
Published: November 2024

ABSTRACTPlatform owners like SAP, Eclipse Foundation, and Microsoft have developed partnership models to expand their software ecosystems. These models govern the cluster of complementors, enabling the attraction and maintenance of partners and consumers. Companies aiming to define new partnership models when moving from a software product approach to an ecosystem face challenges that may limit their growth. When establishing an emerging ecosystem, platform providers (i.e., keystones) must perform several activities, such as attracting and retaining partners, defining rules of participation, managing risks, and maintaining the quality of the platform. This paper proposes three strategic patterns to assist companies in structuring their partnership models. The patterns provide actionable guidance to companies establishing new ecosystems. We adopted the Design Science Research (DSR) method to conduct the study. Following the DSR cycle, the strategic patterns were defined using a Multivocal Literature Review. The strategies described in the proposed patterns were validated by the industry professionals with experience in emerging software ecosystems. The proposed patterns help keystone companies adopt suitable strategies to address the following challenges: selecting partners, attracting and retaining consumers, technically structuring the platform while maintaining the robustness of the ecosystem, managing risks and conflicts, and assisting complementors in developing, selling, and distributing solutions in the ecosystem.
Post‐earthquake structural damage identification and safety evaluation using point clouds
Authors: Yu Runze , Li Peizhen , Liu Chang , Zhai Guanghao , Shan Jiazeng 
Published: November 2024

AbstractEfficient and accurate post‐earthquake damage assessment of building structures is critical for ensuring the human safety and structural integrity of affected buildings. However, manual inspections and traditional visual damage identification methods are often constrained by the inaccessibility of hard‐to‐reach regions and the subjectivity of human inspectors. To overcome these issues, this paper proposes a novel approach for rapid and precise post‐earthquake damage identification and evaluation using unmanned aerial vehicle (UAV) and point cloud techniques, significantly reducing the time, labor, and errors associated with traditional methods. A comprehensive testing on full‐scale reinforced concrete shear walls was conducted to validate the precision and feasibility of this method. The point cloud models of the shear wall were generated leveraging UAV imagery and laser scanning technology with millimeter‐scale accuracy. The proposed algorithm effectively segmented each target plane of the shear wall, achieving a relatively satisfactory overall Intersection over Union of 99.25%. The relative errors of deformation between the algorithm's identification and gauges measurements were within 5%. This study successfully segmented and quantified structural surface damage, including cracks and spalling. Finally, the structural safety of the shear wall was evaluated according to ATC‐20 guidelines, using indicators such as inclination, story drift ratio, crack width, and damage area. Furthermore, proposed method was also verified in real cases.
Combination Using Magnetic Iron Oxide Nanoparticles and Magnetic Field for Cancer Therapy
Authors: Sun Wenjun , Chai Xiaoxia , Zhang Yuan , Yu Tongyao , Wang Yuhua , Zhao Wenzhe , Liu Yanhua , Yin Dachuan , Zhang Chenyan 
Published: November 2024

AbstractIron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing magnetic fields have also gathered increasing attention in the biomedical field. However, the defects of difficult dispersion and poor biocompatibility of MNPs seriously hinder their application. In order to overcome its inherent defects and maximize the therapeutic potential of MNPs, various functionalized MNPs have been developed, and numerous combined treatment methods based on MNPs have been widely studied. In this review, we compare and analyze the common nanoparticles based on MNPs with different sizes, shapes, and functional modifications. Additionally, we introduced the therapeutic mechanisms of the strategies, such as magnetically controlled targeting, magnetic hyperthermia, and magneto‐mechanical effect, which based on the unique magnetic induction capabilities of MNPs. Finally, main challenges of MNPs as smart nanomaterials were also discussed. This review seeks to offer a thorough overview of MNPs in biomedicine and a new sight for their application in tumor treatment.
Pseudomonas monteilii and Enterococcus faecalis in a free‐living Megascops choliba: Epidemiological implications
Authors: de Andrade Julia Penna , Pereira Luiz Filipe Moreira , Figueirêdo Rezende Julie Vasconcelos , Faria Soares Camilla , da Silva Martins Nelson Rodrigo 
Published: November 2024

AbstractEnterococcus spp. and Pseudomonas spp. are significant pathogens due to their ability to form biofilms and express resistance genes. The role of wildlife in the transmission of bacterial resistance genes remains inadequately understood, underscoring the need for a comprehensive understanding of transference dynamics and their potential as bioindicators. This case report details a free‐living screech owl (Megascops choliba) presenting with prostration, inability to fly and a lacerative lesion with bone exposure on the left wing. Bacteriological analysis was carried out by collecting a swab sample in Stuart agar after antisepsis of the wing lesion. Isolates were grown aerobically overnight at 37°C, and the results were submitted to matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry for identification. Antimicrobial susceptibility testing was conducted using the standard disc diffusion method on Mueller–Hinton agar. Antibiotic susceptibility tests revealed resistance of both isolates, emphasising the threat of antimicrobial resistance and the need for monitoring and addressing antimicrobial resistance in wildlife.
The “Who,” “What,” and “Why” of student leadership training
Authors: Kroll Jonathan R. , Beatty Cameron C. , Manning‐Ouellette Amber 
Published: November 2024

AbstractThis article provides a foundational framework for understanding student leadership training. The authors categorize the article into three key areas: the who defines student leadership trainers as educators who intentionally foster leadership development, with a strong focus on identity exploration, leadership knowledge, and experiential learning. The what explores the nature of leadership training, distinguishing it from leadership education, development, and engagement, emphasizing skill cultivation in immersive settings. The why highlights the importance of leadership training, stressing practical skill development, reflection, and real‐world application. The article positions leadership training as essential for empowering students to engage with leadership challenges through hands‐on, reflective experiences that enhance their competencies. Ultimately, this article serves as an introduction to the special issue on leadership development in training contexts.
Conclusion: Towards Further Research into the Platformization of the Family
Authors: Mannell Kate , Sefton-Green Julian , Erstad Ola 
Published: November 2024

AbstractThe final chapter of the book brings together key ideas, theories, and questions raised across the book to propose an agenda for progressing research on the platformization of the family. It summarises the key dimensions of platforms and families and proposes a theory of extended-domestication that bridges the micro and macro elements of these dimensions.
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
Authors: da Silva Lima Natália , Cabaleiro Alba , Novoa Eva , Riobello Cristina , Knerr Patrick J. , He Yantao , Esquinas-Román Eva M. , González-García Ismael , Prevot Vincent , Schwaninger Markus , Dieguez Carlos , López Miguel , Müller Timo D. , Varela-Rey Marta , Douros Jonathan D. , Nogueiras Ruben 
Published: November 2024

AbstractThe use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencing considerable interest. However, whether these compounds have a direct action on MASH is still under debate. This study aims to investigate whether GLP-1R/GIPR agonists act directly in hepatocytes and hepatic stellate cells (HSCs). For this, human hepatocyte and HSCs lines, as well as primary human hepatocytes and HSCs treated with Liraglutide, Acyl-GIP or the GLP-1/GIP dual agonist (MAR709) were used. We show that the concentrations of each compound, which were effective in insulin release, did not induce discernible alterations in either hepatocytes or HSCs. In hepatocytes displaying elevated fatty acid content after the treatment with oleic acid and palmitic acid, none of the three compounds reduced lipid concentration. Similarly, in HSCs activated with transforming growth factor-β (TGFb), Liraglutide, Acyl-GIP and MAR709 failed to ameliorate the elevated expression of fibrotic markers. The three compounds were also ineffective in phosphorylating CREB, which mediates insulinotropic actions, in both hepatocytes and HSCs. These findings indicate that incretin agonists have no direct actions in human hepatocytes or hepatic stellate cells, suggesting that their beneficial effects in patients with MASH are likely mediated indirectly, potentially through improvements in body weight, insulin resistance and glycemic control.
Supercyclic Properties of Extended Eigenoperators of the Differentiation Operator on the Space of Entire Functions
Authors: González Manuel , León-Saavedra Fernando , Rosa María Pilar Romero de la 
Published: November 2024

Abstract
A continuous linear operator L defined on the space of entire functions

$$\mathcal {H}({\mathbb {C}})$$

H
(
C
)

is said to be an extended

$$\lambda $$

λ

-eigenoperator of the differentiation operator D provided

$$DL=\lambda LD$$

D
L
=
λ
L
D

. Here we fully characterize when an extended

$$\lambda $$

λ

-eigenoperator of D is supercyclic, it has a hypercyclic subspace or it has a supercyclic subspace.
Arzneimittelinteraktionen bei kritisch Kranken
Authors: Bellmann Romuald , Weiler Stefan 
Published: November 2024

ZusammenfassungBei kritisch Kranken besteht ein hohes Risko für unerwünschte Arzneimittelinteraktionen. Pharmakodynamische Interaktionen können Organtoxizität verstärken. Pharmakokinetische Interaktionen gründen meist auf einer Hemmung oder Induktion von Enzymen des Arzneimittelmetabolismus wie Cytochrom-P-450-Isoenzymen und Transporterproteinen wie P‑Glykoprotein. Inhibitoren dieser Moleküle können so toxische Wirkspiegel der entsprechenden Substrate herbeiführen, Induktoren hingegen subtherapeutische Konzentrationen. Amiodaron, Makrolide, Azol-Antimykotika, direkt wirksame Antikoagulanzien, Vitamin-K-Antagonisten, Immunsuppressiva, Rifampicin und einige ZNS-wirksame Substanzen sind besonders häufig an Interaktionen beteiligt. Eine Überprüfung der Medikation unter strenger Risiko-Nutzen-Abwägung, therapeutisches Drugmonitoring, Verwendung elektronischer Alert-Systeme und Datenbanken zusammen mit klinischer Bewertung können zur Vermeidung unerwünschter Arzneimittelinteraktionen beitragen.
Exchange rates of second generation Microcuff® pediatric endotracheal tubes in children weighing more than 3 kg
Authors: Schmidt-Deubig Ilka , Kemper Michael , Wendel-Garcia Pedro D. , Weiss Markus , Thomas Jörg , Both Christian Peter , Schmitz Achim 
Published: November 2024

Abstract
Background
Cuffed endotracheal tubes (cETT) pose the potential advantage of an infrequent need for reintubation in pediatric patients compared to uncuffed tubes. The aim of this study was to investigate tube exchange rates using second generation Microcuff® pediatric endotracheal tubes (PET) with an adapted sizing recommendation in a large single institution cohort of children and to identify potential variables associated with an elevated risk of tube exchange.

Methods
Patient data obtained from the electronic patient data management system of the Department of Anesthesia, University Children’s Hospital Zurich, Switzerland, were retrospectively assessed for demographic and anthropometric information, size of the internal tube diameter used for positive pressure ventilation and divergence from the size recommendation chart.

Results
Data from 14,188 children younger than 16 years (median 5.3 years) and weighing at least 3 kg who underwent oral or nasal tracheal intubation using second generation Microcuff® PET between 2009 and 2015 were included. Of 13,219 oral tracheal intubations 12,049 (84.9%) were performed according to the manufacturer’s size recommendation and 1170 with divergent endotracheal tubes. The odds ratio (OR) of oral reintubation was 0.13% (95% confidence interval 0.08–0.22%) for cases using the manufacture’s size recommendation correctly and 22.74% (95% confidence interval 20.42–25.23%) for patients intubated with a not recommended tube (p < 0.0001).

Conclusion
These findings indicate that the second generation Microcuff® PETs can be reliably used with low tube exchange rates across the entire pediatric age range when the tube size is selected according to the manufacturer’s size recommendation chart. Adherence to the manufacturer’s tube size recommendation is urgently advised.
Evaluating the capacity of magnetic ionic liquids for separation and concentration of non-enveloped viral particles and free viral genomic RNA
Authors: Stoufer Sloane , Kim Minji , De Silva Shashini , Anderson Jared L. , Brehm-Stecher Byron F. , Moore Matthew D. 
Published: November 2024

AbstractMagnetic ionic liquids (MILs) have proven effective as capture reagents for foodborne bacterial pathogens; however, there are currently no published studies regarding their use with foodborne, non-enveloped viruses. In this study, a protocol was evaluated for capture and recovery of bacteriophage MS2, a human norovirus surrogate, and purified viral genomic single stranded RNA (ssRNA) from an aqueous suspension using MILs. Transition metal-based MILs showed similar capture and recovery efficiency for both targets. A rare earth metal-based MIL showed much greater capture efficiency than the transition metal-based MILs, but displayed similar recovery. All tested MILs showed slightly higher capture and recovery efficiency for free RNA in comparison to intact virus, though overall trends were similar, and most MILs could recover both targets at as little as 102 PFU/mL intact MS2 or copies/mL purified RNA. A plaque assay confirmed that contact with MILs did not significantly reduce viral infectivity. Adjusting MIL volume gave no significant changes in capture or recovery, likely due to interplay between volume for the hydrophobic MIL and dispersion. Reducing the elution volume gave a slight increase in recovery, indicating MILs could be used for target enrichment after further optimization. MILs could also capture MS2 from romaine lettuce rinsate at comparable or even higher levels than from pure suspension, though loss in recovery was observed when the rinsate was prepared in an alkaline elution buffer. Overall, these results demonstrate the potential utility of MILs as concentration reagents for foodborne viruses, particularly for in-field applications.
Graphical Abstract
Does inbreeding affect personality traits? An experimental study in a precocial bird
Authors: Beccardi Matteo , Moiron Maria , Salmón Pablo , Tschirren Barbara , Vedder Oscar 
Published: November 2024

AbstractInbreeding is known to have deleterious effects on offspring performance, but the extent to which such inbreeding depression acts on traits is widely variable. In particular, condition-dependent traits that are subject to directional selection are expected to show stronger inbreeding depression. However, while inbreeding effects on primary determinants of fitness have been thoroughly investigated, the impact of inbreeding on other potentially condition-dependent traits such as behavioural and “personality” traits remain little studied. Here, we performed experimental matings between full-siblings and unrelated individuals of Japanese quail (Coturnix japonica) and tested the effect of inbreeding on eight behavioural traits hypothesized to be linked to “personality” differences. Structural equation modelling revealed that these traits were part of a behavioural syndrome involving two a priori hypothesised latent variables, described as emotivity and neophobia. These were underlying all the measured behavioural traits and covaried negatively. Yet, we found no behavioural differences between inbred and outbred offspring, except for tonic immobility, which was longer in inbred offspring. We therefore conclude that inbreeding only has limited effects on behavioural traits linked to personality, suggesting that variation in these behaviours is not underlain by rare recessive deleterious alleles, as predicted when a trait is not condition dependent.
Reflection-aware 3D mirror segmentation and pose estimation
Authors: Madeira Tiago , Oliveira Miguel , Dias Paulo 
Published: November 2024

AbstractReflective surfaces are notoriously difficult to detect and reconstruct, as they reflect light from surrounding objects. Thus, the quality of 3D reconstructions and the performance of downstream computer vision tasks, such as navigation, depth prediction, or object detection are severely impaired by the prevalence of mirrors in indoor environments. This paper proposes a novel reflection-aware method for 3D mirror segmentation and pose estimation, based on the reinterpretation of captured RGB-D data. It is a top-down approach, where information consensus, unsupervised learning, and ray casting are employed, formulating mirror pose estimation as an optimization problem. Experimental results show that the proposed approach significantly outperforms the existing benchmarks for RGB and RGB-D-based 3D mirror segmentation and pose estimation.