bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the form of venous thromboembolism prophylaxis following primary total knee arthroplasty alter the rate of early reoperation or revision surgery?
Authors: Kerr David L. , Butler Stephen , Read Andrew C. , Harris Ian A. 
Published: June 2019

BackgroundCurrently there is significant variation in the management of venous thromboembolism prophylaxis following total knee arthroplasty (TKA). Excessive wound ooze and bleeding is thought to increase a patient's risk of haematoma formation and possible infection. We evaluated the rate of unexpected reoperation in the perioperative period in patients who received aspirin, rivaroxaban or enoxaparin following primary TKA.MethodA systematic literature search was conducted in MEDLINE, CENTRAL and Embase to identify patients who underwent primary TKA. Two researchers independently reviewed the references identified in the literature search. The final 11 studies included for review were published between 1996 and 2016.ResultsThere was a higher rate of reoperation in patients treated with aspirin following TKA when compared to enoxaparin and rivaroxaban in the perioperative period. Of the 5141 patients treated with enoxaparin, 11 (0.21%) required reoperation; of the 2764 patients treated with rivaroxaban, 12 (0.43%) required reoperation; and of the 228 patients treated with aspirin, seven (3.07%) required reoperation. The average time to follow‐up in the 11 studies was 55 days, ranging from 30 to 180 days post‐operatively.ConclusionThere was a higher rate of reoperation in patients treated with aspirin following TKA when compared to enoxaparin and rivaroxaban in the perioperative period. While there is extensive data on the safety and efficacy of these medications following joint arthroplasty, improved reporting of surgically relevant outcomes are needed to assist both the surgeon and patient in clinical decision‐making.
Site‐specific absence of microfibrillar‐associated protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane: an immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoarthritis
Authors: Christensen Anne Friesgaard , Sorensen Grith Lykke , Junker Kirsten , Revald Peter , Varnum Claus , Issa Saida Farah , Junker Peter , Sorensen Flemming Brandt 
Published: June 2019

Microfibrillar‐associated protein 4 (MFAP4) is a non‐structural matrix protein with cell regulatory activities and a potential as seromarker for fibrosis. We aimed to study the occurrence of MFAP4 in the synovial membrane from patients with rheumatoid arthritis (RA) vs osteoarthritis (OA). Formaldehyde‐fixed synovial tissue sections, from patients with RA (N = 6) and OA (N = 6) undergoing total hip arthroplasty, were deparaffinized and immunostained with monoclonal antibodies against MFAP4. Elastin was detected using ElastiKit. MFAP4 in serum (sMFAP4) and synovial fluid was measured by an immunoassay. MFAP4 was present in synovial biopsies from both RA and OA patients, particularly prominent in deep arterioles where it colocalized with elastin. Notably however, MFAP4 was absent from the internal elastic lamina in RA arterioles irrespective of disease duration and synovitis activity, while present although with irregular staining patterns in OA specimens. sMFAP4 was increased in RA and OA serum vs healthy controls: median (interquartile range) 29.8 (25.3–39.1) and 25.5 U/L (18.1–43.3) vs 17.7 U/L (13.7–21.2), p = 0.006 and p = 0.02, respectively The concentration of synovial fluid was lower than in serum in both RA and OA. These findings may suggest that MFAP4 is involved in adaptive vessel wall remodeling associated with chronic joint disease.
Early clinical outcomes of helical tomotherapy/intensity‐modulated proton therapy combination in nasopharynx cancer
Authors: Park Seung Gyu , Ahn Yong Chan , Oh Dongryul , Noh Jae Myoung , Ju Sang Gyu , Kwon Dongyeol , Jo Kwanghyun , Chung Kwangzoo , Chung Eunah , Lee Woojin , Park Seyjoon 
Published: June 2019

AbstractThis study aimed to evaluate the feasibility of combining helical tomotherapy (HT) and intensity‐modulated proton therapy (IMPT) in treating patients with nasopharynx cancer (NPC). From January 2016 to March 2018, 98 patients received definitive radiation therapy (RT) with concurrent chemotherapy (CCRT). Using simultaneous integrated boost and adaptive re‐plan, 3 different dose levels were prescribed: 68.4 Gy in 30 parts to gross tumor volume (GTV), 60 Gy in 30 parts to high‐risk clinical target volume (CTV), and 36 Gy in 18 parts to low‐risk CTV. In all patients, the initial 18 fractions were delivered by HT, and, after rival plan evaluation on the adaptive re‐plan, the later 12 fractions were delivered either by HT in 63 patients (64.3%, HT only) or IMPT in 35 patients (35.7%, HT/IMPT combination), respectively. Propensity‐score matching was conducted to control differences in patient characteristics. In all patients, grade ≥ 2 mucositis (69.8% vs 45.7%, P = .019) and grade ≥ 2 analgesic usage (54% vs 37.1%, P = .110) were found to be less frequent in HT/IMPT group. In matched patients, grade ≥ 2 mucositis were still less frequent numerically in HT/IMPT group (62.9% vs 45.7%, P = .150). In univariate analysis, stage IV disease and larger GTV volume were associated with increased grade ≥ 2 mucositis. There was no significant factor in multivariate analysis. With the median 14 month follow‐up, locoregional and distant failures occurred in 9 (9.2%) and 12 (12.2%) patients without difference by RT modality. In conclusion, comparable early oncologic outcomes with more favorable acute toxicity profiles were achievable by HT/IMPT combination in treating NPC patients.
Managing soils for resolving the conflict between agriculture and nature: The hard talk
Authors: Lal Rattan 
Published: June 2019

AbstractAmong soil‐centric options for addressing global issues being intensely debated by soil scientists, ecologists and earth scientists regarding their effectiveness and applicability are: (a) harnessing soil carbon (C) sink capacity for adaptation and mitigation of climate change; (b) reducing soil erosion as a source of greenhouse gases and the need to include it in the global C budget; (c) enhancing use efficiency of inputs to agroecosystems and returning land, water and other resources back to nature; (d) using global drylands, saline culture, halomorphic plants and brackish water for provisioning of ecosystem services; and (e) adopting a system‐based conservation agriculture for eco‐intensification of agroecosystems as a strategy of “producing more from less”. Not only should agriculture be made a solution for addressing global issues, but it is also essential to reconciling the need for advancing food and nutritional security with the absolute necessity of enhancing the environment, restoring degraded soils and desertified ecosystems, and advancing Sustainable Development Goals or the Agenda 2030.HighlightsSustainable soil management, degraded soil restoration abridging agronomic yield gap and improving the environment are important to achieve world peace.Sustainable eco‐intensification of agro‐ecosystems reduces inputs and enhances use efficiency by restoring soil health.Harnessing soil carbon sink capacity includes reducing accelerated soil erosion for adaptation and mitigation of climate change.System‐based conservation agriculture sustains agronomic productivity and minimizes soil degradation and environmental pollution.
Prevalence of adverse events and their effect on completion of high speed treadmill exercise tests at a single institution (2000–2015)
Authors: Brown K. , Stefanovski D. , Davidson E. 
Published: June 2019

SummaryBackgroundDecline in high speed treadmill (HSTM) exercise testing may be attributed to the rise of over‐ground endoscopy and telemetric electrocardiography, in addition to concerns of adverse events during treadmill exercise resulting in injury or inadequate testing.ObjectivesTo describe adverse events occurring during HSTM exercise tests at a single institution and determine their effect on likelihood of completing diagnostic HSTM exercise testing.Study designRetrospective cohort study.MethodsPearson’s chi‐square test was used to determine if a significant difference in frequencies of adverse events existed between complete and incomplete HSTM exercise tests. Two Firth logistic regression models were used to determine likelihood of exercise test completion given the presence of any adverse event, and the likelihood of exercise test completion for each type of adverse event.ResultsThe majority of horses presenting for HSTM evaluation underwent exercise testing (900/1003; 90%). Eight‐hundred and seven (90%) exercise tests were completed. Adverse events occurred in 136 (15%) HSTM exercise tests of which 97 (71%) did not impact ability to complete HSTM testing. Adverse events significantly but variably decreased the likelihood of HSTM exercise test completion. Sixty‐six percent of incomplete exercise tests were prematurely terminated due to poor performance abnormalities during which diagnosis of poor performance cause(s) was still achieved.Main limitationsVariable personnel recorded data over the study period. Per‐test rather than per‐horse evaluation does not account for the effect of multiple training and testing episodes performed in the same horse.ConclusionsThis study supports the continued usage of HSTM exercise testing for examination of horses with poor performance, with adverse events occurring infrequently. Adverse events reduced the likelihood of completing HSTM exercise testing although not all adverse events affected likelihood of completion similarly. In many cases, a performance limiting problem was identified for horses in which an exercise test was considered incomplete.The Summary is available in Spanish – see Supporting information
The development of Nursing Quality Care Process Metrics and Indicators for use in Older Persons Care Settings: A Delphi‐Consensus Study
Authors: Murphy Fiona , Doody Owen , Lyons Rosemary , Gallen Anne , Nolan Mary , Killeen Angela , Kavanagh Paula , Donegan Joan , Sezgin Duygu 
Published: June 2019

AbstractAimTo develop a suite of nursing quality care process metrics and indicators for older persons care settings in Ireland.BackgroundRegulatory investigations of health system failures highlight non‐adherence to clinical guidelines and standards resulting in deficiencies in nursing care delivery. Limited attention has been paid to measuring nursing care processes particularly in the care of older people. Quality care process metrics can facilitate measurement of nurse‐sensitive measures of care.DesignA scoping literature review and modified Delphi‐Consensus Technique.MethodsA scoping review of literature published between January 2007 – January 2017 was conducted to identify nursing process metrics and indicators. The Delphi Consensus phase incorporated a four‐round electronic survey of 404 nurses and a consensus meeting with 13 stakeholders working in Older Persons Care Settings in Ireland.FindingsFrom the review, 33 potential metrics were identified. After all Delphi survey rounds, 20 metrics and 90 associated indicators were selected by the nurses. Following the consensus meeting, 19 metrics and 80 indicators were included in the final suite of nursing quality care process metrics and indicators.ConclusionDeveloping this suite of nursing quality care process metrics and indicators for use in older persons care settings provided consensus on what nursing processes should be measured to improve the quality and safety of care delivery.ImpactThe nursing processes identified, provide a framework for future research and educational programmes in the care of older persons. Although conducted in the Irish healthcare system, there is potential for adoption or adaption in other healthcare settings.
Effectiveness of the application of massage therapy and kinesitherapy by parents on premature neonates: A research protocol
Authors: Álvarez‐Álvarez María José , Fernández‐García Daniel , Gómez‐Salgado Juan , Ordás Beatriz , Rodríguez‐González María Dolores , Martínez‐Isasi Santiago 
Published: June 2019

AbstractAimThe study aims to analyse the efficacy of massage therapy and kinesitherapy applied by parents of premature infants admitted to hospital.BackgroundPremature newborns suffer early somatic deprivation that has adverse effects on their growth and development and that also has a negative impact on the emotional state of their parents. Massage therapy and kinesitherapy is beneficial in alleviating somatic deficit and facilitates the bond between parents and newborns.DesignA quasi‐experimental community intervention trial will be conducted in a neonatology unit.MethodsThis study will compare the benefits of a 15‐min massage protocol applied by parents with the usual medical and nursing care given by neonatal units for premature babies. The evaluation of neuromotor development will take place through the Spanish Premie‐Neuro scale. The determination of weight, size, and head circumference will be based on the unit's usual procedures.DiscussionIf the implementation of a massage therapy and kinesitherapy protocol is effective in promoting the growth and development of hospitalized premature infants, the results of this study could give an impetus for the inclusion of somatic stimulation in the usual nursing care given for preterm infants.ImpactPrematurity and its associated morbidity pose a major global public health problem. Somatic and kinaesthetic stimulation has beneficial effects on anthropometric and neuromotor development in preterm infants. The results will have a positive impact on premature neonates and their families, both during the hospitalization, and a positive socio‐economic effect throughout their lives (education, work, disability).Trial registration: NCT03704012.
Assessing historical and future habitat models for four conservation‐priority Mojave Desert species
Authors: Guida Ross J. , Abella Scott R. , Roberts Chris L. , Norman Carrie M. , Smith William J. 
Published: June 2019

AbstractAimModelling and quantifying habitat changes using three historical field surveys for four Mojave Desert species and projecting future scenarios.LocationNewberry Mountains, southern Nevada, USA.MethodsThree vegetation field surveys were conducted, ending in 1979, 2008 and 2016, respectively. Field data collection across three time steps resulted in a unique dataset with 100 re‐surveyed 0.06‐ha plots. Using Maxent ecological niche modelling and 800‐m resolution Parameter Elevation Regressions on Independent Slopes Model (PRISM) temperature and precipitation data, habitat was assessed for four high‐elevation species. Recognizing that missing location data is a common challenge in species distribution modelling, sensitivity analysis was conducted utilizing three high‐elevation plots that species inhabited during the first two field surveys but that were unable to be sampled in 2016. Area under the curve for three species’ model runs exceeded 0.95, while one wider‐distributed species exceeded 0.79 for all runs. Future scenarios were also modelled under temperature increases and 16% and 0% reductions in precipitation.ResultsThe number of presence locations and densities for Juniperus californica, Pinus monophylla, Quercus turbinella and Yucca schidigera decreased from 1979 to 2016, while their average elevational distribution increased. Using the 100 plots measured each of the three study years, models for all four species indicated decreases in potential suitable habitat ranging from 10% to 45%. When including the three highest elevation plots not re‐sampled in 2016, but likely still containing the modelled species, modelled habitat loss ranged from 0% to 29%. Future model projections show drastic reductions in the suitable habitat of all four modelled species.Main conclusionsWhile many Maxent ecological modelling studies have been conducted, few have incorporated repeat surveys of identical plots as in our study. Model projections using a unique 100‐plot dataset suggest that suitable habitat area is contracting for the species studied, and this correlated with climatic warming and drying in the Mojave Desert. Despite model projections that show nearly complete loss of suitable habitat in 2053, care should be taken given uncertain estimates of the velocity of climate change and the slower pace of habitat contractions measured in the field.
Isobaric tag for relative and absolute quantitation based quantitative proteomics reveals unique urinary protein profiles in patients with preeclampsia
Authors: Ding Wenyan , Qiu Bintao , Cram David S. , Chen Xiuting , Li Shengjie , Zhou Xiya , Liu Juntao , Wu Zhihong , Song Yijun 
Published: June 2019

AbstractPreeclampsia (PE) is one of the most significant pregnancy‐related hypertensive disorders. Currently, there are no useful markers to predict the onset of the condition in pregnant women. To provide further insights into the pathogenesis of PE and identify biomarkers of the condition, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomics coupled with 2‐D LC‐MS/MS, to analyze urinary protein profiles from 7 PE patients and 7 normotensive pregnant women. A total of 294 proteins were abnormally expressed in PE patients. Of these, 233 were significantly down‐regulated and 61 proteins were significantly up‐regulated. Bioinformatics analysis using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database, found that the most differentially expressed proteins (DEPs) were involved in coagulation and complement pathways, the renin‐angiotensin system and cell adhesion molecules (CAMs) pathways. We further validated three of the DEPs, including serotransferrin (TF) and complement factor B (CFB) by immunoblottingand serum paraoxonase/arylesterase 1 (PON1) by ELISA using 14 pairs of urine samples from PE patients and normal pregnant women. Taken together, our results provide the basis for further understanding the pathogenesis of PE and identifying predictive biomarkers.
Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report
Authors: Shin Young‐Bin , Choi Won‐Jun , Kim Chiyeon 
Published: June 2019

AbstractCutaneous angiosarcoma (CA) is a rare and aggressive malignant tumor that develops from vascular endothelium. Secondary CAs are often caused by radiotherapy and chronic lymphedema. Most radiation‐induced CAs are associated with breast or gynecologic cancer. The prognosis of CA is extremely poor, with a 5‐year survival rate ranging from 12% to 34%. Therapeutic options are limited, and surgical excision with negative margins remains the mainstay of treatment. We report a case of a 63‐year‐old woman who developed secondary CA at an irradiated site 7 years after receiving radiotherapy for cervical cancer.
Influence of simplified dietary advice combined with new complete denture fabrication on masticatory function of complete denture wearers
Authors: Suzuki Hiroyuki , Kanazawa Manabu , Komagamine Yuriko , Iwaki Maiko , Amagai Noriko , Minakuchi Shunsuke 
Published: June 2019

AbstractBackgroundDietary advice combined with prosthetic treatment could improve dietary intake earlier than prosthetic treatment only. This early improvement might signify early adaptation to new prostheses. Therefore, dietary advice might affect functional adaptation to new prostheses.ObjectiveThe aim was to clarify the influence of simple dietary advice on masticatory function of elderly individuals with new complete dentures.MethodsA randomised controlled trial was performed on 59 edentulous elderly individuals who had received new complete dentures. Participants were randomly divided into an intervention group (received simple dietary advice: 15 men and 15 women, mean age: 74.8 ± 8.0 years) or a control group (received denture care advice: 15 men and 14 women, mean age: 78.6 ± 6.8 years). Masticatory function was assessed using colour‐changeable chewing gum for mixing ability and test gummy jelly for shearing ability. Mixing and shearing ability were assessed at pre‐treatment, and 3 and 6 months post‐treatment. At each assessment time, mixing ability was compared using Student's t test and shearing ability using Mann‐Whitney's U test. Within‐group differences in mixing ability were analysed using repeated‐measures one‐way analysis of variance and those in shearing ability were analysed using Wilcoxon signed‐rank test with Bonferroni correction.ResultsAt each assessment time, there was no significant difference in mixing or shearing ability between groups. In the intervention group, mixing and shearing ability significantly increased at 3 and 6 months post‐treatment. In the control group, mixing ability significantly increased at 6 months post‐treatment.ConclusionSimple dietary advice might lead to relatively early improvements in masticatory function.
Lichenoid reaction with granulomatous stomatitis: A retrospective histologic study of 47 patients
Authors: Hakeem Abdulaziz , Bhattacharyya Indraneel , Aljabri Mohammed , Bindakhil Mohammed , Pachigar Krunal , Islam Mohammed N. , Cohen Donald M. , Fitzpatrick Sarah G. 
Published: June 2019

AbstractObjectivesLichenoid granulomatous reaction can be subcategorized into lichenoid granulomatous dermatitis or lichenoid granulomatous stomatitis. It is described in the literature as demonstrating a band‐like lichenoid infiltration with clusters of histiocytic or granuloma formation. In this study, we presented a large case series of lichenoid granulomatous stomatitis including demographics, histological features, and subcategories and compared findings with current literature.Methods and materialsWe retrieved all cases diagnosed with lichenoid reaction with granulomatous inflammation between January 1, 2000, and August 1, 2016, from the University of Florida Oral Pathology Biopsy Service Archives.ResultsA total of 47 patients with tissue from 50 biopsy sites were included. The majority of the cases were noted in females (64%) with a mean age of 59 years (range 30‐88). Most patients were Caucasian, and the most common sites in descending order were: gingiva, buccal mucosa, vestibule, tongue, lip, palate, and occasional multifocal involvement. Clinical impressions by the treating clinicians included leukoplakia, dysplasia, carcinoma in situ, squamous cell carcinoma, lichen planus, vesiculobullous disease, trauma, and allergy. The histologic features of these cases ranged from lichenoid mucositis with numerous aggregates of histiocytes to well‐formed granulomas, in accordance with previous classifications of similar dermatologic lesions. All cases revealed positive CD 68 in the histiocytic infiltrates and were negative for microorganisms utilizing acid‐fast bacilli, Grocott methenamine‐silver, and periodic acid‐Schiff stains.ConclusionLichenoid granulomatous disease may be more common than previously reported; however, its etiology remains unknown and patients should be kept under long‐term clinical follow‐up.