bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Immune and Nutritional Biomarkers on Illness Risk During Interval Training
Authors: Hanstock Helen G. , Govus Andrew D. , Stenqvist Thomas B. , Melin Anna K. , Sylta Øystein , Torstveit Monica K. 
Published: April 2019

Intensive training periods may negatively influence immune function, but the immunological consequences of specific high-intensity-training (HIT) prescriptions are not well defined. Purpose: To explore whether 3 different HIT prescriptions influence multiple health-related biomarkers and whether biomarker responses to HIT were associated with upper-respiratory-illness (URI) risk. Methods: Twenty-five male cyclists and triathletes were randomized to 3 HIT groups and completed 12 HIT sessions over 4 wk. Peak oxygen consumption () was determined using an incremental cycling protocol, while resting serum biomarkers (cortisol, testosterone, 25[OH]D, and ferritin), salivary immunoglobulin-A (s-IgA), and energy availability (EA) were assessed before and after the training intervention. Participants self-reported upper-respiratory symptoms during the intervention, and episodes of URI were identified retrospectively. Results: Fourteen athletes reported URIs, but there were no differences in incidence, duration, or severity between groups. Increased risk of URI was associated with higher s-IgA secretion rates (odds ratio = 0.90, 90% confidence interval 0.83–0.97). Lower preintervention cortisol and higher EA predicted a 4% increase in URI duration. Participants with higher reported higher total symptom scores (incidence rate ratio = 1.07, 90% confidence interval 1.01–1.13). Conclusions: Although multiple biomarkers were weakly associated with risk of URI, the direction of associations between s-IgA, cortisol, EA, and URI risk were inverse to previous observations and physiological rationale. There was a cluster of URIs in the first week of the training intervention, but no samples were collected at this time point. Future studies should incorporate more-frequent sample time points, especially around the onset of new training regimens, and include athletes with suspected or known nutritional deficiencies.
Acute Resistance Exercise: Physiological and Biomechanical Alterations During a Subsequent Swim Training Session
Authors: Arsoniadis Gavriil G. , Bogdanis Gregory C. , Terzis Gerasimos , Toubekis Argyris G. 
Published: April 2019

Purpose: To examine the acute effect of dry-land strength training on physiological and biomechanical parameters in a subsequent swim training session. Methods: Twelve male swimmers (age: 19.0 [2.2] y, peak oxygen uptake: 65.5 [11.4] mL·kg−1·min−1) performed a 5 × 200-m test with progressively increasing intensity. Blood lactate (BL) concentration was measured after each 200-m bout, and the speed corresponding to 4 mmol·L−1 (V4) was calculated. In the experimental (EXP) and control (CON) conditions, swimmers participated in a swim training session consisting of 1000-m warm-up, a bout of 10-second tethered swimming sprint, and 5 × 400 m at V4. In EXP condition, swimmers completed a dry-land strength training session (load: 85% of 1-repetition maximum) 15 minutes before the swimming session. In CON condition, swimmers performed the swimming session only. Oxygen uptake, BL concentration, arm-stroke rate, arm-stroke length, and arm-stroke efficiency were measured during the 5 × 400 m. Results: Force in the 10-second sprint was not different between conditions (P = .61), but fatigue index was higher in the EXP condition (P = .03). BL concentration was higher in EXP condition and showed large effect size at the fifth 400-m repetition compared with CON condition (6.4 [2.7] vs 4.6 [2.8] mmol·L−1, d = 0.63). During the 5 × 400 m, arm-stroke efficiency remained unchanged, arm-stroke length was decreased from the third repetition onward (P = .01), and arm-stroke rate showed a medium increment in EXP condition (d = 0.23). Conclusions: Strength training completed 15 minutes before a swim training session caused moderate changes in biomechanical parameters and increased BL concentration during swimming. Despite these changes, swimmers were able to maintain force and submaximal speed during the endurance training session.
Effects of an Eccentric Hamstrings Training on Components of Physical Performance in Young Female Handball Players
Authors: Chaabene Helmi , Negra Yassine , Moran Jason , Prieske Olaf , Sammoud Senda , Ramirez-Campillo Rodrigo , Granacher Urs 
Published: April 2019

Purpose: This study examined the effects of an 8-week Nordic hamstring exercise (NHE) training on components of physical performance in young female handball players. Methods: Participants were allocated to an experimental group (EG; n = 10; age: 15.9 [0.2] y) and a control group (CG; n = 9; age: 15.9 [0.3] y). The EG performed NHE (2–3 sessions/wk) in replacement of some handball-specific drills, whereas the CG followed regular handball training. Pretraining and posttraining tests were carried out for the assessment of sprint speed (5 m, 10 m, and 20 m), jump performance (countermovement jump [CMJ] height), change-of-direction (t test), and repeated-sprint ability (RSA total time [RSAtotal], RSA best time [RSAbest], and RSA fatigue index [RSAFI]). Data were analyzed using magnitude-based inferences. Results: Within-group analyses for the EG showed moderate performance improvements for 5, 10, and 20 m (effect size [ES] = 0.68–0.82), t test (ES = 0.74), and CMJ (ES = 0.85). Trivial to small improvements were observed for RSA (ES = −0.06 to 0.35). For the CG, within-group outcomes showed performance decrements with moderate (t test [ES = 0.71]), small (5 m [ES = 0.46] and RSAbest [ES = 0.20]), and trivial magnitude (10 m [ES = 0.10], 20 m [ES = 0.16], and RSAtotal [ES = 0.00]). Furthermore, trivial to small performance improvements were found for CMJ (ES = 0.10) and RSAFI (ES = 0.5). Between-group analyses revealed small to large effects in favor of EG for 5 m (ES = 1.07), 10 m (ES = 0.66), 20 m (ES = 0.53), t test (ES = 1.38), and RSA (ES = 0.68–0.78). A trivial between-group difference was demonstrated for CMJ (ES = −0.01). Conclusions: The NHE training intervention, in replacement of some handball-specific drills, was more effective than regular handball training in improving physical performance (ie, linear sprint time, jumping, change-of-direction, and RSA) in young female handball players.
What are the prevalence and factors associated with sexual dysfunction in breastfeeding women? A Brazilian cross-sectional analytical study
Authors: Fuentealba-Torres Miguel , Cartagena-Ramos Denisse , Fronteira Inês , Lara Lúcia Alves , Arroyo Luiz Henrique , Arcoverde Marcos Augusto Moraes , Yamamura Mellina , Nascimento Lucila Castanheira , Arcêncio Ricardo Alexandre 
Published: April 2019

ObjectiveThis study determined the prevalence and factors associated with sexual dysfunction in breastfeeding women.DesignCross-sectional analytical study.SettingPopulation-based study of individuals living in the northeast region of São Paulo state, Brazil.ParticipantsFrom May to August 2017, 372 women aged ≥18 years were selected who gave exclusive, predominant or complementary breast feeding up to 23 months postpartum, and who did not have contraindications for the resumption of intercourse. Pregnant women, those diagnosed with mental health problems, users of medications that affect sexual function (antihypertensives, antidepressants or antipsychotics) and women unable to read or understand the instructions for the study were excluded.Primary and secondary outcome measuresThe breastfeeding women completed the Female Sexual Function Index, the EUROHIS-QOL 8-item index and a questionnaire to collect participants’ sociodemographic, clinical and interpersonal data. A bivariate analysis was performed, and variables with p values<0.20 were analysed by multivariate logistic regression.ResultsSexual dysfunction was present in 58.3% of the study population. Factors significantly associated with female sexual dysfunction (FSD) included placing a low importance on sexual intercourse (adjusted OR [AOR]=2.49, 95% CI=1.22 to 5.09), limited communication with the partner (AOR=2.64, 95% CI=1.43 to 4.86), decreased frequency of sexual intercourse (AOR=2.17, 95% CI=1.30 to 3.61) and low quality of life (AOR=2.23, 95% CI=1.33 to 3.74).ConclusionsThe prevalence of FSD appears with a great magnitude in breastfeeding women. The risk factors for sexual dysfunction are biopsychosocial and these findings may lead to improved counselling for prenatal and postnatal care.
Perceptual timing in children with attention-deficit/hyperactivity disorder (ADHD) as measured by computer-based experiments versus real-life tasks: protocol for a cross-sectional experimental study in an ambulatory setting
Authors: Marx Ivo , Reis Olaf , Berger Christoph 
Published: April 2019

IntroductionThe goal of this study is to get a better understanding of the fundamentals of perceptual timing deficits, that is, difficulties with estimating durations of explicitly attended temporal intervals, in children with attention-deficit/hyperactivity disorder (ADHD). Whereas these deficits were repeatedly demonstrated in laboratory studies using computer-based timing tasks, we will additionally implement a more practical task reflecting real-life activity. In doing so, the research questions of the planned study follow a hierarchically structured path ‘from lab to life’: Are the timing abilities of children with ADHD really disturbed both in the range of milliseconds and in the range of seconds? What causes these deficits? Do children with ADHD rather display a global perceptual timing deficit, or do different ‘timing types’ exist? Are timing deficits present during real-life activities as well, and are they based on the same mechanisms as in computerised tasks?Methods and analysesA quasi-experimental study with two groups of male children aged 8–12 years (ADHD; controls) and with a cross-sectional design will be used to address our research questions. Statistical analyses of the dependent variables will comprise (repeated) measures analyses of variance, stepwise multiple regression analyses and latent class models. With an estimated dropout rate of 25%, power analysis indicated a sample size of 140 subjects (70 ADHD, 70 controls) to detect medium effect sizes.Ethics and disseminationEthics approval was obtained from the ethics committee of the Faculty of Medicine, University of Rostock. Results will be disseminated to researcher, clinician and patient communities in peer-reviewed journals and at scientific conferences, at a meeting of the local ADHD competence network and on our web page which will summarise the study results in an easily comprehensible manner.Trial registration numberDRKS00015760
‘It’s a powerful message’: a qualitative study of Australian healthcare professionals’ perceptions of asthma through the medium of drawings
Authors: Cheung Melissa Mei Yin , Saini Bandana , Smith Lorraine 
Published: April 2019

ObjectivesThis study aimed to explore healthcare professionals’ (HCPs’) perspectives of asthma through their drawings, and their responses when viewing patients’ drawings of their experiences of asthma.DesignA qualitative exploratory study with a purposive, convenience sample of participants. Participants were asked to first express their perspectives of asthma in a drawing, which was followed by a review of drawings made by patients with asthma.SettingPrimary and tertiary HCPs from Sydney, Australia.ParticipantsTwenty-three HCPs from a range of health professions.ResultsThe HCPs illustrated their perspective of asthma through drawings which were largely biomedically framed, depicting physiological and clinical aspects of asthma. In contrast, their discussion around the patients’ drawings centred on the person more than the condition. The patients’ drawings triggered the HCPs to revisit their personal expectations of their patients’ illness experience; prompted differing degrees of acknowledgement and empathy regarding the patient experience; and encouraged clinical reflexivity.ConclusionsOur findings provide support for the educational application of patients’ drawings in bringing HCPs closer to the patient lived experience. The drawings fostered deeper insight into patient perspectives of asthma and stimulated critical reflection on current healthcare practices.
Current barriers, facilitators and future improvements to advance quality of abortion care: views of women
Authors: Smith Jodie Louise , Cameron Sharon 
Published: April 2019

BackgroundBarriers to accessing abortion care continue to exist even in settings where abortion is legal. We aimed to determine current barriers faced by women seeking abortion, factors that facilitate access to care, and what future improvements women would like made to abortion care in Scotland.MethodsA self-administered anonymous questionnaire of women requesting abortion care at a community abortion service in Edinburgh. Women selected the top three options from predefined lists of barriers to seeking abortion, facilitators of care, and future service improvements.Results154/165 (93%) questionnaires were completed by women presenting for abortion. The most commonly ranked number one barrier to seeking an abortion (n = 49; 32%) was ‘being scared about what the abortion process involved’. The highest ranked facilitator of care was information provided to women via the abortion clinic website. The most commonly chosen number one response for potential improvement to abortion services was the option to get an early medical abortion from a general practitioner, which was chosen by 70 (45%) women.ConclusionsThis study suggests that lack of knowledge and information surrounding the abortion process and the ease with which women can receive abortion care are areas of concern. Efforts are needed to reduce waiting times, to ensure that high-quality, standardised information is widely and publicly available regarding what women can expect during the abortion process, and to expand provision of early medical abortion within the community, in order to improve abortion care.
Use of cholesterol and soluble tumour markers CEA and syndecan-2 in pleural effusions in cases of inconclusive cytology
Authors: Gulyas Miklos , Fillinger Janos , Kaposi Andras D , Molnar Miklos 
Published: April 2019

AimsIn order to improve diagnostics in pleural effusions, additional value of effusion cholesterol, carcinoembryonic antigen (CEA) and syndecan-2 assays to cytology was studied.MethodsBiomarkers were measured in effusion supernatants from 247 patients, of whom 126 had malignant pleural involvement, and their additional diagnostic efficacy to cytology was assessed.ResultsSyndecan-2 measurement, although gave detectable concentrations in all effusions with highest median value in mesotheliomas, was non-discriminative between different pathological conditions. CEA concentrations exceeding 5 ng/mL cut-off point indicated carcinomas, regardless of pleural involvement, which gave a sensitivity of 62% and specificity of 100% for carcinoma. Cholesterol concentration over 1.21 mmol/L cut-off value indicated neoplastic pleural involvement with 99% sensitivity and ‘merely’ 69% specificity, the latter mainly due to raised levels being associated also with benign inflammatory effusions. Combined CEA and cholesterol determinations increased the sensitivity for diagnosing carcinomatosis from 70% with cytology alone to 84% and established the correct diagnosis in 16 of 31 carcinomatosis cases with inconclusive cytology. Cholesterol measurement alone, with elevated level, in combination with absence of substantial number of inflammatory cells in effusion sediment proved to be a magnificent marker for neoplastic pleural involvement with 99% efficacy, and recognised all 36 such cases with inconclusive cytology.ConclusionsSimultaneous measurement of CEA and cholesterol concentrations in effusion, or at least cholesterol alone, in combination with non-inflammatory fluid cytology, provides additional specific information about neoplastic pleural involvement, and can therefore be used as an adjunct to cytology, above all, in inconclusive cases.
Day case complex devices: the state of the UK
Authors: Waight Michael , Elawady Abdula , Gage Heather , Touray Morro , Adhya Shaumik 
Published: April 2019

ObjectiveComplex cardiac devices including implantable cardioverter defibrillator (ICD) and cardiac resynchronisation therapy (CRT) devices can safely be implanted as a day case procedure as opposed to overnight stay. We assess how common day case complex device therapy is and the cost implications of more widespread adoption across the UK.MethodsA freedom of information request was sent to all centres performing complex cardiac devices across the UK to assess the adoption of this technique. Cost implications were assessed using Department of Health National Schedule of Reference Costs 2016–2017.Results100 UK centres were surveyed, 80% replied. Eighty per cent of UK centres already implant complex cardiac devices as a day case to some extent. 64.06% of centres have a protocol for this. 12.82% of centres do <25% of complex devices as a day case. 15.38% do 25%–50% as day case. 17.95% do 50%–75% as day case and 33.33% do >75% as day case. There was no relationship between centre volume and the proportion of devices done as a day case as opposed to overnight stay. The cost saving of performing a complex device as a day case as opposed to overnight stay was £412 per ICD, £525 per CRT-pacemaker and £2169 per CRT-defibrillator.ConclusionsDay case complex devices are already widespread across the UK, however, there is scope for increase. An increase in proportion of day case devices could translate to £5 583 265 in savings annually for the National Health Service if all centres performed 75% of devices as a day case.
Neural respiratory drive predicts long-term outcome following admission for exacerbation of COPD: a post hoc analysis
Authors: Patout Maxime , Meira Leonor , D’Cruz Rebecca , Lhuillier Elodie , Kaltsakas Georgios , Arbane Gill , Suh Eui-Sik , Hart Nicholas , Murphy Patrick Brian 
Published: April 2019

Neural respiratory drive (NRD), as reflected by change in parasternal muscle electromyogram (EMGpara), predicts clinical deterioration and safe discharge in patients admitted to hospital with an acute exacerbation of COPD (AECOPD). The clinical utility of NRD to predict the long-term outcome of patients following hospital admission with an AECOPD is unknown. We undertook a post hoc analysis of a previously published prospective observational cohort study measuring NRD in 120 patients with AECOPD. Sixty-nine (57.5%) patients died during follow-up (median 3.6 years). Respiratory failure was the most common cause of death (n=29; 42%). In multivariate analysis, factors independently associated with an increased mortality included NRD (HR 2.14, 95% CI 1.29 to 3.54, p=0.003), age (HR 2.03, 95% CI 1.23 to 3.34, p=0.006), PaCO2at admission (HR 1.83, 95% CI 1.06 to 3.06, p=0.022) and long-term oxygen use (HR 2.98, 95% CI 1.47 to 6.03, p=0.002). NRD at hospital discharge could be measured in order to assess efficacy of interventions targeted to optimise COPD and reduce mortality following an AECOPD.Original clinicaltrial.gov number:NCT01361451
Influence of the efficacy of a probiotic complex containing Bacillus subtilis and Pichia farinosa on the growth performance and fecal microbiota of finishing pigs
Authors: Wang Huan , Kim In Ho 
Published: April 2019

A total of 120 finish pigs [(Landrace × Yorkshire) × Duroc; 52.61 ± 2.37 kg] were randomly allotted into three treatments for a 70 d trial to evaluate the growth performance and fecal microbiota counts in finishing pigs. Treatment groups were (i) basal diet (CON), (ii) CON + 0.1% probiotic complex (TRT1), and (iii) CON + 0.2% probiotic complex (TRT2). Each treatment consisted of eight replicate pens with five pigs per pen. The average daily gain and fecal Lactobacillus counts of TRT2 were increased (P < 0.05) compared with CON treatment. The result showed that 0.2% complex probiotic was more effective than 0.1%.
Humus composition of mineral–microbial residue from microbial utilization of lignin involving different mineral types
Authors: Wang Shuai , Chen Dianyuan , Zhang Xi , Xu Junping , Lei Wanying , Zhou Changyan , Chen Chen , Li Fanghui , Wang Nan 
Published: April 2019

This study explored the mineral contribution of lignin to humus (HS) formation through the change of HS composition in microbial–mineral residue (MMR). The liquid shake flask culture method was adopted to collect the MMR formed through the microbial utilization of lignin in the presence of goethite, bayerite, δ-MnO2, kaolinite, and montmorillonite. The carbon (C) contents of humic-like acid (HLA), fulvic-like acid (FLA), and humin-like (HLu) in MMR, represented as CHLA, CFLA, and CHLu, respectively, coupled with the ΔlogK of the HLA alkali-soluble extract and CHLA/CFLA ratio were analyzed at 10, 30, 60, and 110 d. In terms of improving HLA aggregated on minerals, the following rule was observed: goethite > bayerite > montmorillonite > kaolinite ≈δ-MnO2. Goethite was most likely to adsorb organic molecules with a high degree of polymerization. Compared with kaolinite and montmorillonite, goethite, bayerite, and δ-MnO2 were more helpful for decreasing the molecular weight and the degree of HLA condensation. Goethite, δ-MnO2, and montmorillonite presented the greatest advantages in enhancing the relative proportions of CHLA, CFLA, and CHLu, respectively, in MMR. In MMR formed in the presence of kaolinite, goethite, and bayerite, CHLA was decreased by 14.8%, 12.0%, and 5.8%, respectively, at the end of culture, whereas the CHLA associated with δ-MnO2 was increased by 12.0%. δ-MnO2 contributed the most to the conversion of CFLA to CHLA. Due to expandability and a much greater adsorption capacity, montmorillonite was most beneficial to the accumulation of CHLu.
Initiation Condition of Hemodialysis Is Independently Associated with All-Cause Mortality in Maintenance Hemodialysis Patients: A Retrospective Study
Authors: Wang Chang , Yang Yuan , Yuan Fang , Li Hui-Qiong , He Li-Yu , Liu Di , Liu Ye-Xin , Zhou An , Chen Xing , Liu Fu-You , Peng You-Ming , Liu Hong 
Published: April 2019

<b><i>Background:</i></b> Despite the progression of dialysis techniques, the mortality of hemodialysis (HD) patients is still high in China. Here, a retrospective study was performed to investigate the neglected risk factors of all-cause mortality during maintenance HD (MHD). <b><i>Methods:</i></b> We investigated 117 MHD patients who died between 2011 and 2016 in the Second Xiangya Hospital of Central South University HD center. In order to analyze the risk factors of 48 months all-cause death, the methods of Kaplan-Meier and Cox regression were used. <b><i>Results:</i></b> Multivariate analyses of adjusted age and gender showed that MHD patients with estimated glomerular filtration rate &#x3c;7 or &#x3e;10 mL/min/1.73 m<sup>2</sup> and anemia (hemoglobin &#x3c;100 g/L) at the initiation of dialysis are independently associated with the higher death risk. Using central venous catheter vascular access, cerebrovascular comorbidities, diabetes, low-flux dialyzer, and dialysis frequency ≤2 times weekly were also the independent risk factors of death within 48 months. <b><i>Conclusions:</i></b> This study indicated that the status of HD initiation is a risk factor of long-term survival in MHD patients, which were usually ignored for lacking of nephrology care prior and could potentially be identified and modified to improve the survival prognosis. Video Journal Club “Cappuccino with Claudio Ronco” at https://www.karger.com/Journal/ArticleNews/223997?sponsor=52