bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compact Cryo-Adsorbent Hydrogen Storage Systems for Fuel Cell Vehicles
Authors: Tamburello David , Hardy Bruce , Sulic Martin , Kesterson Matthew , Corgnale Claudio , Anton Donald 
Published: October 2018

Numerical models for the evaluation of cryo-adsorbent based hydrogen storage systems for fuel cell vehicles were developed and validated against experimental data. These models simultaneously solve the conservation equations for heat, mass, and momentum together with the equations for the adsorbent thermodynamics. The models also use real gas thermodynamic properties for hydrogen. Model predictions were compared to data for charging and discharging both MOF-5™ and activated carbon systems. Applications of the model include detailed finite element analysis simulations as well as full vehicle-level system analyses. The present work provides an overview of the compacted adsorbent MOF-5™ storage prototype system, as well as a detailed computational analysis and its validation using 2-liter prototype test system. The results of these validated computational analyses are then projected to a full scale vehicle system, based on an 80 KW fuel cell with a 20 kW battery.
This work is part of the Hydrogen Storage Engineering Center of Excellence (HSECoE), which brings materials development and hydrogen storage technology efforts address onboard hydrogen storage in light duty vehicle applications. The HSECoE spans the design space of the vehicle requirements, balance of plant requirements, storage system components, and materials engineering. Theoretical, computational, and experimental efforts are combined to evaluate, design, analyze, and scale potential hydrogen storage systems and their supporting components against the Department of Energy (DOE) 2020 and Ultimate Technical Targets for Hydrogen Storage Systems for Light Duty Vehicles.
Socioeconomic position, symptoms of depression and subsequent mental healthcare treatment: a Danish register-based 6-month follow-up study on a population survey
Authors: Packness Aake , Halling Anders , Hastrup Lene Halling , Simonsen Erik , Wehberg Sonja , Waldorff Frans Boch 
Published: October 2018

ObjectiveExamine whether the severity of symptoms of depression was associated with the type of mental healthcare treatment (MHCT) received, independent of socioeconomic position (SEP).DesignRegister-based 6-month follow-up study on participants from the Danish General Suburban Population Study (GESUS) 2010–2013, who scored the Major Depression Inventory (MDI).ParticipantsNineteen thousand and eleven respondents from GESUS.InterventionsThe MHCT of the participants was tracked in national registers 4 months prior and 6 months after their MDI scores. MHCT was graduated in levels. SEP was defined by years of formal postsecondary education and income categorised into three levels. Data were analysed using logistic and Poisson regression analyses.OutcomesMHCT included number of contacts with: general practitioner (GP), GP mental health counselling, psychologist, psychiatrist, emergency contacts, admissions to psychiatric hospitals and prescriptions of antidepressants.ResultsFor 547 respondents with moderate to severe symptoms of depression there was no difference across SEP in use of services, contact (y/n), frequency of contact or level of treatment, except respondents with low SEP had more frequent contact with their GP. However, of the 547 respondents , 10% had no treatment contacts at all, and 47% had no treatment beyond GP consultation. Among respondents with no/few symptoms of depression, postsecondary education ≥3 years was associated with more contact with specialised services (adjusted OR (aOR) 1.92; 95% CI 1.18 to 3.13); however, this difference did not apply for income; additionally, high SEP was associated with fewer prescriptions of antidepressants (education aOR 0.69; CI 0.50 to 0.95; income aOR 0.56, CI 0.39 to 0.80) compared with low SEP.ConclusionParticipants with symptoms of depression were treated according to the severity of their symptoms, independent of SEP; however, more than half with moderate to severe symptoms received no treatment beyond GP consultation. People in low SEP and no/few symptoms of depression were more often treated with antidepressants. The study was approved by The Danish Data Protection Agency Journal number 2015-41-3984. Accessible at:https://www.datatilsynet.dk/fortegnelsen/soeg-i-fortegnelsen/
Development of a risk predictive scoring system to identify patients at risk of representation to emergency department: a retrospective population-based analysis in Australia
Authors: Ahn Euijoon , Kim Jinman , Rahman Khairunnessa , Baldacchino Tanya , Baird Christine 
Published: October 2018

ObjectiveTo examine the characteristics of frequent visitors (FVs) to emergency departments (EDs) and develop a predictive model to identify those with high risk of a future representations to ED among younger and general population (aged ≤70 years).Design and settingA retrospective analysis of ED data targeting younger and general patients (aged ≤70 years) were collected between 1 January 2009 and 30 June 2016 from a public hospital in Australia.ParticipantsA total of 343 014 ED presentations were identified from 170 134 individual patients.Main outcome measuresProportion of FVs (those attending four or more times annually), demographic characteristics (age, sex, indigenous and marital status), mode of separation (eg, admitted to ward), triage categories, time of arrival to ED, referral on departure and clinical conditions. Statistical estimates using a mixed-effects model to develop a risk predictive scoring system.ResultsThe FVs were characterised by young adulthood (32.53%) to late-middle (26.07%) aged patients with a higher proportion of indigenous (5.7%) and mental health-related presentations (10.92%). They were also more likely to arrive by ambulance (36.95%) and leave at own risk without completing their treatments (9.8%). They were also highly associated with socially disadvantage groups such as people who have been divorced, widowed or separated (12.81%). These findings were then used for the development of a predictive model to identify potential FVs. The performance of our derived risk predictive model was favourable with an area under the receiver operating characteristic (ie, C-statistic) of 65.7%.ConclusionThe development of a demographic and clinical profile of FVs coupled with the use of predictive model can highlight the gaps in interventions and identify new opportunities for better health outcome and planning.
Impact of PCSK9 monoclonal antibodies on circulating hs-CRP levels: a systematic review and meta-analysis of randomised controlled trials
Authors: Cao Ye-Xuan , Li Sha , Liu Hui-Hui , Li Jian-Jun 
Published: October 2018

ObjectiveTo evaluate the potential effects of proprotein convertase subtilisin/kexin type 9 monoclonal antibody (PCSK9-mAb) on high-sensitivity C reactive protein (hs-CRP) concentrations.DesignA systematic review and meta-analysis of randomised controlled trials.Data sourcesPubMed, MEDLINE, the Cochrane Library databases, ClinicalTrials.gov and recent conferences were searched from inception to May 2018.Eligibility criteria for selecting studiesAll randomised controlled trials that reported changes of hs-CRP were included.ResultsTen studies involving 4198 participants were identified. PCSK9-mAbs showed a slight efficacy in reducing hs-CRP (−0.04 mg/L, 95% CI: −0.17 to 0.01) which was not statistically different. The results did not altered when subgroup analyses were performed including PCSK9-mAb types (alirocumab: 0.12 mg/L, 95% CI: −0.18 to 0.43; evolocumab: 0.00 mg/L, 95% CI: −0.07 to 0.07; LY3015014: −0.48 mg/L, 95% CI: −1.28 to 0.32; RG7652: 0.35 mg/L, 95% CI: −0.26 to 0.96), treatment duration (≤12w: 0.00 mg/L, 95% CI: −0.07 to 0.07; >12w: −0.11 mg/L, 95% CI: −0.45 to −0.23), participant characteristics (familial hypercholesterolaemia: 0.00 mg/L, 95% CI: −0.07 to 0.07; non-familial hypercholesterolaemia: 0.07 mg/L, 95% CI: −0.12 to 0.26; mix: −0.48 mg/L, 95% CI: −1.28 to 0.32) and treatment methods (monotherapy: 0.00 mg/L, −0.08 to 0.07; combination therapy: −0.08 mg/L, −0.37 to 0.21). Meta-regression analyses suggested no significant linear correlation between baseline age (p=0.673), sex (p=0.645) and low-density lipoprotein cholesterol reduction (p=0.339).ConclusionsOur updated meta-analysis suggested that PCSK9-mAbs had no significant impact on circulating hs-CRP levels irrespective of PCSK9-mAb types, participant characteristics and treatment duration or methods.
Study protocol for an observational register-based study on health and risk factors in patients with hip and knee osteoarthritis
Authors: Gustafsson Kristin , Rolfson Ola , Eriksson Marit , Dahlberg Leif , Kvist Joanna 
Published: October 2018

IntroductionHip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identification of individuals with slow disease development and a good prognosis, and those that should be recommended for future joint replacement surgery.Methods and analysisThis nationwide register-based study will use data for approximately 75 000 patients who sought and received core treatment for osteoarthritis in primary healthcare, and were registered in the Swedish population-based National Quality Register for Better Management of Patients with Osteoarthritis. These data will be merged with data for replacement surgery, socioeconomic factors, healthcare consumption and comorbidity from the Swedish Hip Arthroplasty Register, the Swedish Knee Arthroplasty Register, Statistics Sweden and the National Board of Health and Welfare, Sweden. The linkage will be performed using personal identity numbers that are unique to all citizens in Sweden.Ethics and disseminationThe study was approved by the Regional Ethical Review Board in Gothenburg, Sweden (dnr 1059–16). The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings.Trial registration numberNCT03438630.
Research priorities in fragility fractures of the lower limb and pelvis: a UK priority setting partnership with the James Lind Alliance
Authors: Fernandez Miguel A , Arnel Laura , Gould Jenny , McGibbon Alwin , Grant Richard , Bell Philip , White Stuart , Baxter Mark , Griffin Xavier , Chesser Tim , Keene David , Kearney Rebecca S , White Catherine , Costa Matthew L 
Published: October 2018

ObjectiveTo determine research priorities in fragility fractures of the lower limb and pelvis which represent the shared priorities of patients, their friends and families, carers and healthcare professionals.Design/settingA national (UK) research priority setting partnership.ParticipantsPatients over 60 years of age who have experienced a fragility fracture of the lower limb or pelvis; carers involved in their care (both in and out of hospital); family and friends of patients; healthcare professionals involved in the treatment of these patients including but not limited to surgeons, anaesthetists, paramedics, nurses, general practitioners, physicians, physiotherapists and occupational therapists.MethodsUsing a multiphase methodology in partnership with the James Lind Alliance over 18 months (August 2016–January 2018), a national scoping survey asked respondents to submit their research uncertainties. These were amalgamated into a smaller number of research questions. The existing evidence was searched to ensure that the questions had not been answered. A second national survey asked respondents to prioritise the research questions. A final shortlist of 25 questions was taken to a multistakeholder workshop where a consensus was reached on the top 10 priorities.ResultsThere were 963 original uncertainties submitted by 365 respondents to the first survey. These original uncertainties were refined into 88 research questions of which 76 were judged to be true uncertainties following a review of the research evidence. Healthcare professionals and other stakeholders (patients, carers, friends and families) were represented equally in the responses. The top 10 represent uncertainties in rehabilitation, pain management, anaesthesia and surgery.ConclusionsWe report the top 10 UK research priorities in patients with fragility fractures of the lower limb and pelvis. The priorities highlight uncertainties in rehabilitation, postoperative physiotherapy, pain, weight-bearing, infection and thromboprophylaxis. The challenge now is to refine and deliver answers to these research priorities.
Caesarean section provision and readiness in Tanzania: analysis of cross-sectional surveys of women and health facilities over time
Authors: Cavallaro Francesca L , Pembe Andrea B , Campbell Oona , Hanson Claudia , Tripathi Vandana , Wong Kerry LM , Radovich Emma , Benova Lenka 
Published: October 2018

ObjectivesTo describe trends in caesarean sections and facilities performing caesareans over time in Tanzania and examine the readiness of such facilities in terms of infrastructure, equipment and staffing.DesignNationally representative, repeated cross-sectional surveys of women and health facilities.SettingTanzania.ParticipantsWomen of reproductive age and health facility staff.Main outcome measuresPopulation-based caesarean rate, absolute annual number of caesareans, percentage of facilities reporting to perform caesareans and three readiness indicators for safe caesarean care: availability of consistent electricity, 24 hour schedule for caesarean and anaesthesia providers, and availability of all general anaesthesia equipment.ResultsThe caesarean rate in Tanzania increased threefold from 2% in 1996 to 6% in 2015–16, while the total number of births increased by 60%. As a result, the absolute number of caesareans increased almost fivefold to 120 000 caesareans per year. The main mechanism sustaining the increase in caesareans was the doubling of median caesarean volume among public hospitals, from 17 caesareans per month in 2006 to 35 in 2014–15. The number of facilities performing caesareans increased only modestly over the same period. Less than half (43%) of caesareans in Tanzania in 2014–15 were performed in facilities meeting the three readiness indicators. Consistent electricity was widely available, and 24 hour schedules for caesarean and (less systematically) anaesthesia providers were observed in most facilities; however, the availability of all general anaesthesia equipment was the least commonly reported indicator, present in only 44% of all facilities (34% of public hospitals).ConclusionsGiven the rising trend in numbers of caesareans, urgent improvements in the availability of general anaesthesia equipment and trained anaesthesia staff should be made to ensure the safety of caesareans. Initial efforts should focus on improving anaesthesia provision in public and faith-based organisation hospitals, which together perform more than 90% of all caesareans in Tanzania.
Real-world evidence for postgraduate students and professionals in healthcare: protocol for the design of a blended massive open online course
Authors: Meinert Edward , Alturkistani Abrar , Car Josip , Carter Alison , Wells Glenn , Brindley David 
Published: October 2018

IntroductionThere is an increased need for improving data science skills of healthcare professionals. Massive open online courses (MOOCs) provide the opportunity to train professionals in a sustainable and cost-effective way. We present a protocol for the design and development of a blended MOOC on real-world evidence (RWE) aimed at improving RWE data science skills. The primary objective is to provide the opportunity to understand the fundamentals of RWE data science and to implement methods for analysing RWD. The blended format of MOOC will combine the expertise of healthcare professionals joining the course online with the on-campus students. We expect learners to take skills taught in MOOC and use them to seek new employment or to explore entpreneurship activities in these domains.Methods and analysisThe proposed MOOC will be developed through a blended format using the Analysis, Design, Development, Implementation and Evaluation instructional design model and following the connectivist–heutagogical learning theories (as a hybrid MOOC). The target learners will include postgraduate students and professionals working in the health-related roles with interest in data science. An evaluation of MOOC will be performed to assess MOOCs success in meeting its intended outcomes and to improve future iterations of the course.Ethics and disseminationThe education course design protocol was approved by EIT Health (grant 18654) as part of the EIT Health CAMPUS Deferred Call for Innovative Education 2018. Results will be published in a peer-reviewed journal.
Qualitative protocol for understanding the contribution of Australian policy in the urban planning, justice, energy and environment sectors to promoting health and health equity
Authors: Baum Fran , Delany-Crowe Toni , Fisher Matthew , MacDougall Colin , Harris Patrick , McDermott Dennis , Marinova Dora 
Published: October 2018

IntroductionA well-established body of literature demonstrates that health and equity are strongly influenced by the consequences of governments’ policy and resultant actions (or inactions) outside the health sector. Consequently, the United Nations, and its agency the WHO, have called for national leadership and whole-of-government action to understand and address the health impacts of policies inallsectors. This research responds to that call by investigating how policymaking in four sectors—urban planning, justice, energy and environment—may influence the social determinants of health and health equity (SDH/HE).Methods and analysisThe research design is informed by a critical qualitative approach. Three successive stages are included in the design. The first involves analysing all strategic policy documents and selected legislative documents from the four sectors (n=583). The document analysis is based on a coding framework developed to identify alignment between the documents and the SDH/HE. Two policies that demonstrate good practice in regard to SDH/HE will be selected from each sector during the second stage for embedded case study analysis (total n=8). This is intended to illuminate which factors have supported recognition and action on SDH/HE in the selected policies. The third stage involves progressive theoretical integration and development to understand political and institutional facilitators and barriers to action on SDH/HE, both within and between sectors.Ethics and disseminationThe research will provide much needed evidence about how coherent whole-of-government action on SDH/HE can be advanced and contribute knowledge about how health-enhancing policy activity in the four sectors may be optimised. Learnings from the research will be shared via a project advisory group, policy briefings, academic papers, conference presentations and research symposia. Ethics approval has been secured for the embedded case studies, which involve research participants.
Postpartum quality improvement strategy for increasing long-acting contraception uptake at a University Hospital in Haiti
Authors: Casella Jean-Baptiste Meredith , Louis Stephanie , Millien Christophe , Jeune Erwine Dina , Sainterant Ornella , Joseph Jean Paul 
Published: October 2018

To address the gap in the uptake of long-acting contraception (LAC) methods among high-risk postpartum women who fail to return for a family planning method at HôpitalUniversitaire de Mirebalais in the Central Plateau Department of Haiti, contraceptive implant trainings were held for providers on the Labour and Delivery, Post-Partum and Internal Medicine inpatient wards.A very high maternal mortality rate affects large numbers of women in Haiti; however, contraceptive use can reduce maternal mortality significantly. A quality improvement strategy to offer LAC methods to immediate postpartum women at a University Hospital in rural Haiti was initiated in March 2016. This new strategy produced an average improvement from 5% to 32% of women delivering at the hospital, accepting a long-acting method (including bilateral tubal ligations) by the end of the project and which has proved sustainable at an average of 20% to date.
Quantitative study of genetic gain for growth, carcass, and morphological traits of Nelore cattle
Authors: da Silveira Daniel Duarte , De Vargas Lucas , Pereira Rodrigo Junqueira , Campos Gabriel Soares , Vaz Ricardo Zambarda , Lôbo Raysildo Barbosa , de Souza Fabio Ricardo Pablos , Boligon Arione Augusti 
Published: October 2018

The aim of this study was to evaluate the genetic variability, genetic and phenotypic associations, and genetic gains of birth (BW), weaning (WW), and yearling (YW) weights, loin muscle area (LMA), backfat thickness (BF), rump fat thickness (RF), scores of body structure (BS), finishing precocity (FS), and muscling (MS) in Nelore cattle. Genetic parameters were obtained through Bayesian inference using BLUPF90 programs. All studied traits showed genetic variability, with heritability ranging from 0.29 to 0.47. In all studied ages, weights presented positive genetic correlations with LMA (ranging from 0.13 to 0.53), being generally stronger in comparison with the other carcass traits analyzed (BF and RF). Similarly, weights were higher genetic associated with BS (0.47–0.92) than with FS (0.18–0.62) and MS (0.22–0.65), respectively. The BF and RF showed positive and moderate genetic associations with FS and MS (0.31–0.36). Genetic trends were significant (P < 0.05) and favorable for WW, YW, and visual scores. Selection for increasing BW, WW, YW, and LMA will result in modest or no change in BF and RF (correlated response ranging from −0.04 to 0.07 mm per generation). In this population, carcass traits must be included in the selection indexes to obtain genetic gains in carcass quality, if desired.
Cost Comparison of Collagenase Clostridium Histolyticum and Fasciectomy for Treatment of Dupuytren’s Contracture in the Australian Health System
Authors: Sefton Andrew K. , Smith Belinda J. , Stewart David A. 
Published: October 2018

Background: Dupuytren’s disease results in contracted cords in the hand that lead to deformity and disability. Current treatment options include fasciectomy and an injectable, collagenase clostridium histolyticum. No cost comparison studies have been published within the Australian health care environment. Methods: A retrospective review of all patients treated for Dupuytren’s disease in a major teaching hospital was undertaken to compare the costs of treatment by fasciectomy or collagenase injection. Results: Eighteen patients underwent fasciectomy and 21 collagenase clostridium histolyticum injections were performed during the study period and were eligible for inclusion under the review criteria. Of the 39 patients, 36 were male and 3 were female with an average age 66.4 years (50–85). Twenty-five digits were treated by fasciectomy in 18 patients, and 23 digits were treated by collagenase in 21 patients. The fasciectomy group attended an average 9.2 visits (5–22), incurring an average costing of US$5738.12 per patient ($3181.18–$9618.10). The collagenase group attended an average 3.8 visits (3–8), incurring an average costing of US$2076.83 per patient ($1842.24–$3929.57). Conclusions: Collagenase treatment of Dupuytren’s contracture represents a significant reduction in cost relative to fasciectomy, with 64% savings, length of follow up and number of visits. This is a similar finding to studies in other countries.