bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jagged-1 regulates Foxp3 expression and cytokine production in CD4+ T cells
Authors: Kimura Soichiro , Allen Ronald , Scola Melissa , Lukacs Nicholas W , Kunkel Steven L. , Schaller Matthew 
Published: July 2019

AbstractNotch ligands are present during the interactions between T cells and dendritic cells (DC) and induce a myriad of effects that facilitate the activation of T cells, including the induction of T cell regulation, survival, and cytokine production. Although the ligands Delta-like 4 and Delta-like 1 are expressed as a function of DC activation, the notch ligand Jagged-1 is constitutively expressed on DC. We sought to determine the role of Jagged-1 in the interactions between CD4+ T cells and DC. We observed that Jagged-1 regulates Foxp3 expression, and Cd11cCre+Jaggedff mice have an altered expression of Foxp3 in effector cells that arise as a result of infection with the mycobacterium Bacille Calmette-Guerin. The observed changes in Foxp3 expression were correlated with an increase in cytokine production from cultures of antigen-stimulated draining lymph nodes.
Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact
Authors: Fagan Rita R. , Kearney Patrick J. , Sweeney Carolyn G. , Luethi Dino , Schoot Uiterkamp Florianne E. , Schicker Klaus , Alejandro Brian S. , O’Connor Lauren C. , Sitte Harald H. , Melikian Haley E. 
Published: July 2019

ABSTRACTFollowing its evoked release, DA signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DAT. DAT surface availability is dynamically regulated by endocytic trafficking, and direct PKC activation acutely diminishes DAT surface expression by accelerating DAT internalization. Previous cell line studies demonstrated that PKC-stimulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT. However, it is unknown whether Rit2 is required for PKC-stimulated DAT endocytosis in DAergic terminals, or whether there are region- and/or sex-dependent differences in PKC-stimulated DAT trafficking. Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT endocytosis are unknown. Here, we directly examined these important questions. Ex vivo studies revealed that PKC activation acutely decreased DAT surface expression selectively in ventral, but not dorsal, striatum. AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum. Further, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum. FRET and surface pulldown studies in cell lines revealed that PKC activation drives DAT-Rit2 surface dissociation, and that the DAT N-terminus is required for both PKC-mediated DAT-Rit2 dissociation and DAT internalization. Finally, we found that Rit2 and Ack1 independently converge on DAT to facilitate PKC-stimulated DAT endocytosis. Together, our data provide greater insight into mechanisms that mediate PKC-regulated DAT internalization, and reveal unexpected region-specific differences in PKC-stimulated DAT trafficking in bona fide DAergic terminals.
Sleep spindles mediate hippocampal-neocortical coupling during sharp-wave ripples
Authors: Ngo Hong-Viet. V. , Fell Juergen , Staresina Bernhard P. 
Published: July 2019

AbstractSleep is pivotal for the consolidation of memories [1]. According to two-stage accounts, experiences are temporarily stored in the hippocampus and gradually translocated to neocortical sites during non-rapid-eye-movement (NREM) sleep [2,3]. Mechanistically, information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. In particular, spindles may open precisely-timed communication channels, across which reactivation patterns may travel between the hippocampus and cortical target sites when ripples occur. To test this hypothesis, we first derived time-frequency representations (TFRs) in hippocampus (HIPP) and at scalp electrode Cz (neocortex, NC) time-locked to individual hippocampal ripple events. Compared to matched ripple-free intervals, results revealed a concurrent increase in spindle power both in HIPP and NC. As revealed by coherence analysis, hippocampal-neocortical coupling was indeed enhanced in the spindle band around ripples. Finally, we examined the directionality of spindle coupling and observed a strong driving effect from NC to HIPP. Specifically, ∼250 ms prior to the HIPP ripple, NC spindles emerge and entrain HIPP spindles. Both regions then remain synchronised until ∼500 ms after the ripple. Consistent with recent rodent work, these findings suggest that active consolidation is initiated by neocortex and draws on neocortical-hippocampal-neocortical reactivation loops [4], with a role of sleep spindles in mediating this process.
Three Dimensional Root CT Segmentation using Multi-Resolution Encoder-Decoder Networks
Authors: Soltaninejad Mohammadreza , Sturrock Craig J. , Griffiths Marcus , Pridmore Tony P. , Pound Michael P. 
Published: July 2019

AbstractWe address the complex problem of reliably segmenting root structure from soil in X-ray Computed Tomography (CT) images. We utilise a deep learning approach, and propose a state-of-the-art multi-resolution architecture based on encoder-decoders. While previous work in encoder-decoders implies the use of multiple resolutions simply by downsampling and upsampling images, we make this process explicit, with branches of the network tasked separately with obtaining local high-resolution segmentation, and wider low-resolution contextual information. The complete network is a memory efficient implementation that is still able to resolve small root detail in large volumetric images. We evaluate our approach by comparing against a number of different encoder-decoder based architectures from the literature, as well as a popular existing image analysis tool designed for root CT segmentation. We show qualitatively and quantitatively that a multi-resolution approach offers substantial accuracy improvements over a both a small receptive field size in a deep network, or a larger receptive field in a shallower network. We obtain a Dice score of 0.59 compared with 0.41 for the closest competing method. We then further improve performance using an incremental learning approach, in which failures in the original network are used to generate harder negative training examples. Results of this process raise the precision of the network, and improve the Dice score to 0.66. Our proposed method requires no user interaction, is fully automatic, and identifies large and fine root material throughout the whole volume. The 3D segmented output of our method is well-connected, allowing the recovery of structured representations of root system architecture, and so may be successfully utilised in root phenotyping.
The impact of different forms of organisational support and work–life balance in Chile and Colombia
Authors: Idrovo Sandra , Bosch María José 
Published: July 2019

Purpose
The purpose of this paper is to explore how family-supportive supervisor behaviour (FSSB) and organisational work–family policies (WFP) influence turnover intention (TI), satisfaction with work–family balance (SWFB) and prosocial motivation (PSM) in employees in organisations in the private sector in Colombia and Chile. It also explores whether a family -friendly organisational culture (FFOC) moderates this relationship.

Design/methodology/approach
A questionnaire (the International Family-Responsible Employed Index) was used to survey 486 employees (Chile: 255, Colombia: 231). The questionnaire consisted of three main sections: independent variables (WFP, FSSB, (FFOC and individual characteristics); dependent variables (organisational outcomes of TI, loyalty and commitment, and individual outcomes of health, WFE, SWFB, PSM and intrinsic); and demographic indicators. Structural equation modelling was used to test the possibility of comparing both countries and the model proposed.

Findings
Results show a negative relationship between FSSB and TI, and a positive relationship between FSSB and SWFB and PSM. There are no significant differences among countries, except when looking at PSM. FFOC moderates the relationships between FSSB and TI, between policies and FSSB and SWFB and between FSSB and PSM. It also has a direct effect on PSM.

Originality/value
This paper is one of the first to offer comparative data from organisations and managers in Latin American countries at the work–family interface. It also contributes to the literature, offering results partly consistent with studies in Anglo–Saxon countries.
Selected quality traits of table eggs depending on storage time and temperature
Authors: Brodacki Antoni , Batkowska Justyna , Drabik Kamil , Chabroszewska Patrycja , Łuczkiewicz Przemysław 
Published: July 2019

Purpose
The purpose of this paper is to evaluate changes in selected quality traits of chicken table eggs during their storage under standard storage conditions and in refrigeration.

Design/methodology/approach
The sample consisted of 570 eggs from Hy-Line hens. The eggs were placed on trays of 30 pieces each, and then group C (control) eggs were stored at 14°C temperature and 70 per cent humidity and group F (experimental) eggs were refrigerated at 5°C and 30 per cent humidity. Changes in egg mass and air cell depth were measured on the laying day and, then, after every 7 days for 5 weeks for group C and for up to 24 weeks for group F. Initially for every week and then after every four weeks, the quality of 30 eggs from each group was evaluated. The following traits were analysed: whole egg (mass, specific gravity), shell (conductivity, strength, mass, thickness, and density) and content (proportions, pH, albumen quality and yolk colour).

Findings
It was shown that due to a significant limitation of qualitative changes (lower water loss, higher specific mass, lower shell conductivity, better albumen quality, lower pH content, more favourable proportions of morphological elements) in eggs stored in refrigeration despite prolonged time, reduced temperature should be considered as a factor allowing for a significant prolongation of egg shelf life during storage.

Originality/value
The unusually elongated time of the experiment allows for a practical implementation of the results, especially in the case of eggs intended for processing.
Participatory HRM and firm performance
Authors: Gahlawat Neha , Kundu Subhash C. 
Published: July 2019

PurposeThe purpose of this paper is to examine the relationship between participatory HRM and firm performance through a series of mediators.Design/methodology/approachPrimary data were collected from 569 respondents belonging to 207 organizations operating in India. Structural equation modeling and bootstrapping via PROCESS were used to analyze the hypothesized relationships between participatory HRM and firm performance.FindingsThe study has highlighted that participatory HRM in the form of self-managed teams, flexible work arrangements and empowerment results in better organizational climate, heightened affective commitment, reduced intention to leave and enhanced firm performance. Furthermore, it has been established that organizational climate, affective commitment and intention to leave serially mediate the relationship between participatory HRM and firm performance.Practical implicationsThe study gives strong indications that adopting bundle of participatory HRM practices is beneficial for generating positive organizational climate, enhanced employee attitudes and superior firm performance.Originality/valueBy establishing serial mediation through organizational climate, affective commitment and employees’ intention to leave, this study brings new insights into the interpretation of underlying mechanism existing between participatory HRM and firm performance, thus uniquely contributes to the HRM and OB literature.
Moderating effect of perceived organizational support on the relationship between leader–member exchange and expatriate voice in multinational banks
Authors: Sher Peter Jih-Hsin , Zhuang Wen-Long , Wang Ming-Chieh , Peng Chun-Jung , Lee Chun-Han 
Published: July 2019

Purpose
The purpose of this paper is to examine the effects of home and host country leader–member exchange (LMX) on expatriate voice and determine whether perceived organizational support (POS) moderates the relationship between home or host country LMX and expatriate voice.

Design/methodology/approach
This study surveyed 300 expatriates (expatriation of at least six months) working for Taiwanese banks. The participants had expatriated to Cambodia, Indonesia, Japan, Malaysia, Myanmar, the Philippines, Singapore, the USA and Vietnam. Convenience sampling was adopted.

Findings
Based on an analysis of 132 expatriates working for Taiwanese banks, home and host country LMX were positively related to expatriate voice. Moreover, host country LMX accounted for more variance in expatriate voice than home country LMX did. Financial POS moderated the relationship between home country LMX and expatriate voice. Career POS and adjustment POS moderated the relationships between home and host country LMX and expatriate voice.

Originality/value
In the field of expatriate management, whether expatriate voice is influenced by home and host country LMX requires further exploration. To the best of the authors’ knowledge, this is the first study to examine the effects of home and host country LMX on expatriate voice in host countries, as well as the moderating effect of POS on the aforementioned relationships.
Multiple Sharia' board directorship: a Maslahah (public interest) perspective
Authors: Abd Razak Abd Hakim 
Published: July 2019

Purpose
The purpose of this study is to examine the legal paradigm of multiple Sharia' board directorship practice from the Sharia' law concept of Maslahah Al-Mursalah (public interest).

Design/methodology/approach
It uses a doctrinal research method that relies on the commonly referred sources of Quran and Sunnah, with a specific focus on Maslahah Al-Mursalah and, where applicable, commentaries by contemporary scholars, academics and practitioners as well as translations of classical book of Fiqh. This study scrutinises the polarity of views concerning the distinct Masyaqqah (necessity) surrounding the practice in discussion: the Masyaqqah that encourages and one that discourages the application of the practice.

Findings
This study is keen to suggest the industry to adopt a cautious approach and consider exploring a corporate governance framework that appraises the theoretical and practical Sharia' issues concerning its application in cognisance of its adversarial influence towards the sustainability of Islamic banking industry.

Originality/value
Since Murat Unal’s study of multiple Sharia' board directorships in 2009 and 2011, empirical works that scrutinise the practice from the Sharia' law perspective have remained limited or almost non-existent. It is aspired that this study may assist fellow readers and future researchers alike in evaluating and appreciating the divergent views surrounding the application of this practice in Islamic banking.
The effects of logo frame design on brand extensions
Authors: Chen Yu-Shan Athena , Bei Lien-Ti 
Published: July 2019

Purpose
The purposes of two experiments were to examine how brands may create a broad brand impression and benefit brand extensions by crafting logo frames.

Design/methodology/approach
Two experimental studies were conducted. Study 1 examines how removing and breaking logo frames expands perceived brand breadth. Study 2 considers the implication of this logo frame effect and indicates the impact of logo frames on brand extension scenarios.

Findings
Removing and breaking logo frames could expand perceived brand breadth and, in turn, benefits the brand extensions, especially for promotion-focused consumers. However, prevention-focused people held favorable brand extension attitudes when the brand logo constructs a complete frame due to its perceived trustworthiness.

Research limitations/implications
As an initial exploration, this study conceptualizes and manipulates logo frames as full framed, partial framed and open logo. Future research studies could include further design features in the examination.

Practical implications
If a brand seeks to be broad, removing or breaking its logo frame is an alternative. However, consequential negative impressions on brand extension attitudes among prevention-focused customers should be considered.

Originality/value
This study is the first investigation into the impacts of logo frame patterns on consumers’ perception of brand breadth and the consequent extension attitudes.
Viewpoint: a practitioner’s response to overcoming barriers to access by male participants at cancer resource centers
Authors: Cirone Marianne 
Published: July 2019

Purpose
The purpose of this paper is to provide suggestions regarding how cancer resource center directors, staff and volunteers may encourage men battling cancer, as well as male cancer survivors, to patronize cancer resource centers and to participate in center services.

Design/methodology/approach
This paper provides a personal viewpoint based on research and on the author’s managerial experiences with cancer resource center services, including planning services and programming.

Findings
This paper offers cancer resource center directors suggestions regarding how they can attract male cancer patients to their organizations and encourage their participation in center services.

Research limitations/implications
No limitations were identified.

Practical implications
This paper provides possible strategies for overcoming barriers to access to cancer resource centers in the male cancer-survivor population.

Social implications
Given the medical costs associated with cancer care, encouraging men with cancer to actively participate in cancer resource center programming, which profoundly influences their physical, mental, social and spiritual well-being, can yield many societal benefits.

Originality/value
Cancer resource centers desire to be inclusive of all cancer patients, regardless of gender; however, these centers tend to be disproportionally patronized by women with cancer. This viewpoint addresses how this problem may be addressed via service enhancement, service programming and service design to encourage greater usage by men.
A dialectical vision of mathematical models of complex systems
Authors: Usó Doménech José Luis , Nescolarde-Selva Josué Antonio , Segura-Abad Lorena , Gash Hugh 
Published: July 2019

PurposeMathematical models are constructed at the interface between practice, experience and theories. The function of models puts us on guard against the privilege granted to what is accepted as abstract and formal, and at the same time puts us on guard against a static and phenomenological conception of knowledge. The epistemology of models does not suppress in any way the objectives of science: only, a dogmatic conception concerning truth is removed, and dynamic and dialectical aspects of monitoring are stressed to establish the most viable model. The purpose of this paper is to examine hybrid methodologies (inductive-deductive) that may either propose hypothetical causal relations and seek support for them in field data or detect causal relations in field data and propose hypotheses for the relations detected.Design/methodology/approachThe authors follow a dialectical analysis for a type of inductive-deductive model.FindingsIn this work, the authors present an inductive-deductive methodology whose practical result satisfies the Hegelian dialectic. The consequent implication of their mutual reciprocal integration produces abstractions from the concrete that enable thought. The real problem in this case is a given ontological system or reality.Originality/valueThe essential elements of the models – variables, equations, simulation and feedback – are studied using a dialectic Hegelian theory.
Gender differences in taste and foods habits
Authors: Lombardo Mauro , Aulisa Giovanni , Padua Elvira , Annino Giuseppe , Iellamo Ferdinando , Pratesi Antonio , Caprio Massimiliano , Bellia Alfonso 
Published: July 2019

Purpose
The purpose of this paper is to examine gender differences in food habits and food choices, including decisions in healthy eating, to personalize diet therapies to be as effective possible for long-term weight loss.

Design/methodology/approach
In this cross-sectional study, eating behaviours were assessed using a questionnaire composed of 12 questions concerning food habits, 17 concerning food taste, and four about healthy eating. There were 2,021 (1,276 women) Caucasian adults enrolled in the study.

Findings
Statistically significant differences in women compared to men occurred for the following questionnaire entries reading eating habits: whole grain food (10.0 per cent higher in women; p < 0.001); cereals such as barley (8.3 per cent higher in women, p < 0.001); cooked vegetables (6.6 per cent higher in women, p < 0.001); eggs (5.0 per cent lower in women, p = 0.03); meat (9.3 per cent lower in women, p < 0.001); and processed meat (7.1 per cent lower in women, p < 0.001). Women consume more water, sugar-sweetened beverages and alcoholic drinks than males, and liked salty foods more than sweet foods. Men ate faster, ate more during the night and slept worse than women. Men ate meals out more often and tended to be hungrier later in the day. Women missed more meals and ate more times during the day and were also more likely to eat uncontrollably.

Research limitations/implications
The authors observed strong evidence of profound gender-specific differences between men and women in terms of dietary habits, the taste of food and in the relationship with meals.

Practical implications
The findings suggest a need for the creation of gender-specific programs for promoting a healthy lifestyle.

Social implications
A need for the creation of gender-related programs for promoting healthy lifestyle has been demonstrated.

Originality/value
Reasons for the different eating behaviours among men and women have been found. Western society’s perception of the ideal body weight is much lower for women than for men. In general, social perceptions influence nutritional behaviour to a great extent. Women’s greater nutritional knowledge and sex-specific taste preferences also account for the differences in eating behaviour.