bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical disparity in the oil from leaves of Cinnamomum zeylanicum Blume
Authors: Joshi Rajesh K. 
Published: August 2019

AbstractThe hydrodistilled essential oil obtained from leaves of Cinnamomum zeylanicum Blume (Lauraceae) collected throughout the year was examined using gas chromatography fitted with flame ionization detector (GC‐FID) and gas chromatography connected with mass spectrometry (GC‐MS). The variation in essential oil yield was found to be in the range of 1.1–1.4% (w/w). Between 28 and 40 components, representing 97.92 ± 0.15% of the total oil, were identified. The chief compound was identified as eugenol, varying from 60.24 ± 0.42 to 89.82 ± 0.55%. The other constituents were eugenyl acetate (ranging from 0.10 ± 0.01 to 19.87 ± 0.52%), α‐phellandrene (ranging from 0.76 ± 0.04 to 6.23 ± 0.13%), benzyl benzoate (ranging from 0.91 ± 0.05 to 5.03 ± 0.20%), linalool (ranging from 1.11 ± 0.04 to 3.25 ± 0.08%), and β‐caryophyllene (ranging from 0.50 ± 0.01 to 2.92 ± 0.10%). The essential oils collected throughout the year were found to be rich in phenyl derivative constituents (88.49 ± 0.97%). The biosynthesis and conversion of eugenyl acetate to eugenol appeared as the leaves of C. zeylanicum reached maturity. It was noticed that when leaves were immature, in July and August during the full rainy season, the content of eugenyl acetate was found to be highest, as compared with mature leaves in the other months, with the exception of February (flowering season).
New evidence from the Wuliji'Oboo fluorite deposit for the role of the paleo‐Pacific Plate and Mongol–Okhotsk suture in creating extensive fluorite mineralization in the Great Xing'an Range, NE China
Authors: Zou Hao , Pirajno Franco , Zhang Qiang , Tessalina Svetlana , Ware Bryant , Li Xin‐yu , Liu Hang , Li Yang , Jiang Xiu‐wei , Wei Shao‐yi 
Published: August 2019

The Wuliji'Oboo fluorite deposit is a newly discovered deposit hosted by volcanic rocks of the Early Cretaceous Baiyin'gaolao Formation, which are located in the Great Xing'an Range. Fluorite orebodies within this area are controlled by the NNE‐trending faults. The ΣREE of fluorite samples ranges from 19.18 to 361.22 ppm, with an average of 131.14 ppm. The homogenization temperatures are concentrated in the ranges of 100–150°C and 230–350°C, while the salinity is concentrated in 0.3–1.0 and 2.0–4.5 wt.% NaCl eqv., and the density has ranges of 0.92–0.96 and 0.75–0.8 g/cm3, respectively. The δDV‐SMOW values of fluid inclusions within the fluorite range between −122.3‰ and −105.6‰ with a mean of −115.36‰. The δ18OV‐SMOW of fluorite ranges from −12.0 to −8.5‰, average is −9.9‰. Sm–Nd isotopic data on the fluorite ore yield an isochron age of 122 ± 15 Ma and have ɛNd(t) values ranging from +3.15 to +4.16 and (87Sr/86Sr)i values ranging from 0.704907 to 0.705765. In this contribution, field, petrologic, and geochemical data lead us to the following salient findings: (a) The ore consists of fluorite, quartz, and calcite, with host rock alteration that includes silicification, calcitization, and sericitization. The major element data reveal that the host rocks are a series of highK calc‐alkaline rhyolite. The REEs suggest that F‐rich fluids in this region might have experienced a long‐distance migration. The Tb/Ca‐Tb/La diagram confirms a hydrothermal origin for the deposit. (b) Petrographic evidence and fluid inclusions in the fluorites indicate that this deposit might have two ore‐forming stages. The ore‐forming fluids can be attributed to a NaCl‐H2O‐F system with moderate‐low temperature, low salinity, and low density and have a meteoric water source, with water/rock reaction as the main mechanism for fluorite precipitation. (c) The deposit was formed in an anorogenic within‐plate extensional tectonic setting related to the lithospheric thinning occurring after the Mongolian–Okhotsk Ocean closure.
Delineating functional segregations of the human middle temporal gyrus with resting‐state functional connectivity and coactivation patterns
Authors: Xu Jinping , Lyu Hanqing , Li Tian , Xu Ziyun , Fu Xianjun , Jia Fucang , Wang Jiaojian , Hu Qingmao 
Published: August 2019

AbstractAlthough the middle temporal gyrus (MTG) has been parcellated into subregions with distinguished anatomical connectivity patterns, whether the structural topography of MTG can inform functional segregations of this area remains largely unknown. Accumulating evidence suggests that the brain's underlying organization and function can be directly and effectively delineated with resting‐state functional connectivity (RSFC) by identifying putative functional boundaries between cortical areas. Here, RSFC profiles were used to explore functional segregations of the MTG and defined four subregions from anterior to posterior in two independent datasets, which showed a similar pattern with MTG parcellation scheme obtained using anatomical connectivity. The functional segregations of MTG were further supported by whole brain RSFC, coactivation, and specific RFSC, and coactivation mapping. Furthermore, the fingerprint with predefined 10 networks and functional characterizations of each subregion using meta‐analysis also identified functional distinction between subregions. The specific connectivity analysis and functional characterization indicated that the bilateral most anterior subregions mainly participated in social cognition and semantic processing; the ventral middle subregions were involved in social cognition in left hemisphere and auditory processing in right hemisphere; the bilateral ventro‐posterior subregions participated in action observation, whereas the left subregion was also involved in semantic processing; both of the dorsal subregions in superior temporal sulcus were involved in language, social cognition, and auditory processing. Taken together, our findings demonstrated MTG sharing similar structural and functional topographies and provide more detailed information about the functional organization of the MTG, which may facilitate future clinical and cognitive research on this area.
Thermal performance of an MHD radiative Oldroyd‐B nanofluid by utilizing generalized models for heat and mass fluxes in the presence of bioconvective gyrotactic microorganisms and variable thermal conductivity
Authors: Sohail Muhammad , Naz Rahila , Bilal Sardar 
Published: August 2019

AbstractThe current paper analyzes the thermal and concentration attributes with the temperature‐dependent mass diffusion coefficient and thermal conductivity for the flow of an Oldroyd‐B nanoliquid over a stretchable configuration using the Buongiorno model under the application of boundary layers. The mechanisms of heat and mass transport are modeled by using the revised definitions of heat and mass fluxes. Mathematical expressions for the conservation laws are transformed into ordinary differential expressions by making the appropriate changes. The resulting complexly structured expressions are handled via an optimal homotopy procedure. The impact of influential variables on the desired solutions is plotted, tabulated, and discussed in detail. Comparative analysis of the thermal wall flux coefficient, concentration flux coefficient, density magnitude of the motile microorganisms, and reduced dimensionless stresses with already published research as a limiting case of this exploration is presented for the validity of the proposed scheme, and an excellent agreement is observed, which confirms the reliability of the homotopic solution.
Lay counselors: Thoughts on the crossing of ecological frameworks and the use of lay counselors in the scale up of early infant mental health interventions
Authors: Bain Katherine , Landman Mireille , Frost Katherine , Raphael‐Leff Joan , Baradon Tessa 
Published: August 2019

ABSTRACTThe recent call for the scale‐up of evidence‐based early childhood development interventions, in lower and middle‐income countries and for minority groups in high‐income countries, has seen numerous suggestions to train greater numbers of lay mental health workers to fulfill these functions. While studies have found that concepts from developed country settings, such as attachment, parental sensitivity, and containment, find purchase and relevance within developing settings, the management of contextual and cultural factors and the tensions of cultural interfacing in the rollout of these programs in developing country settings require consideration. Drawing on the experiences of two successful South African mother–infant home‐visiting programs as examples, this article discusses some of the challenges in provision of attachment‐based infant mental health programs and highlights the need for careful consideration of a number of factors pertaining to the recruitment, supervision, and management of lay mental health workers before large‐scale rollout is conducted.
Fluorinated diiodine alkanes exert developmental toxicity on embryo‐larval stages of zebrafish strain AB via regulating the expression of the specific endocrine‐related genes
Authors: Lu Liang , Chang Jia , Chang Yan , Ma Jing 
Published: August 2019

AbstractFluorinated diiodine alkanes (FDIAs) are environmental pollutants, including octafluoro‐1,4‐diiodobutane (PFBDI), hexadecafluoro‐1,8‐diiodooctane (PFODI) and dodecafluoro‐1,6‐diiodohexane (PFHxDI). They showed an estrogenic effect in in vitro studies. However, little information is currently available regarding the toxicity of FDIAs in in vivo studies. Zebrafish (Danio rerio) is a vertebrate animal model that is increasingly used for toxicity and efficacy screening as well as for assessing the toxicity and safety of novel compounds, pollutants and pharmaceuticals. In the present study, we investigated the developmental toxicity of FDIAs (PFBDI, PFHxDI and PFODI) and the specific endocrine‐related gene expression in zebrafish embryos. The results revealed that all three FDIAs showed developmental toxicity on zebrafish embryos. The half‐maximal effective concentration values for PFBDI, PFHxDI and PFODI were 0.89 ± 0.07, 0.53 ± 0.04 and 0.04 ± 0.007 mm, respectively. PFHxDI exhibited the highest developmental toxicity compared with the other FDIAs. In addition, all three FDIAs significantly upregulated the expression of estrogen receptor (esr)1 and cytochrome P450 (CYP) 19b (CYP19b), but did not significantly affect the expression of esr2b, CYP17 and CYP19a in zebrafish. The upregulation effect of PFHxDI was greater than the effect of PFBDI and PFODI. This study furthers our knowledge on the effects of FDIAs on the developmental toxicity and the specific endocrine‐related gene expression in the embryo‐larval stages of zebrafish. Our results provided a preliminary insight into the toxicity of FDIAs in zebrafish, which will be of great relevance regarding future studies on FDIAs in the environment.
Investigation of an equity ethic in engineering and computing doctoral students
Authors: Naphan‐Kingery Dara E. , Miles Monica , Brockman Amanda , McKane Rachel , Botchway Portia , McGee Ebony 
Published: August 2019

AbstractBackgroundResearch shows that engineering and computing students who are marginalized by race and/or gender and experience social suffering often wish to challenge social inequities through their vocation, an attribute we refer to as an equity ethic. This study explores how doctoral engineering and computing students develop this attribute even when they do not directly experience social suffering.Purpose/HypothesisWe explored the relationship between (a) doctoral engineering and computing students' experiences with social suffering and their development of an equity ethic and (b) their equity ethic and career interests.Design/MethodWe present a thematic analysis of the transcripts of in‐depth, semistructured interviews with 18 engineering and computing PhD students, coding for experiences with social suffering, degree of equity ethic, and their career interests.ResultsStudents with an equity ethic who aspired to reduce inequities within their disciplines personally experienced or witnessed social suffering within and outside academia. Students with “high potential” for developing this attribute who aspired to help others with their disciplines acknowledged social suffering. While both those with an equity ethic and those with high potential saw inequities as socially caused, those with an equity ethic reported more impactful experiences with social suffering, resulting in greater empathy and responsibility to respond. Several students described neither altruistic nor social justice concerns (students with low potential) and did not experience social suffering directly or indirectly. Those with an equity ethic or high potential often showed interest in academia.ConclusionsMost participants expressed concerns for helping others in their occupations. This result suggests a nascent equity ethic that could be cultivated through intentional programmatic efforts.
Efficacy and suitable indication of colorectal endoscopic submucosal dissection using a balloon‐assisted endoscope
Authors: Kuroki Yuichiro , Asonuma Kunio , Uehara Natsumi , Endo Toshiyuki , Suzuki Reika , Yamamoto Yorimasa , Nagahama Masatsugu 
Published: August 2019

Background and AimCases of colorectal endoscopic submucosal dissection (ESD) with poor maneuverability are often encountered. We aimed to evaluate the efficacy of balloon‐assisted endoscopy (BAE) for such cases.MethodsWe confirmed maneuverability preoperatively in 400 consecutive cases of colorectal ESD performed at a single center from April 2011 to April 2018. A total of 83 deep colon cases judged as having poor maneuverability were retrospectively reviewed; 54 cases underwent BAE with a single balloon endoscope (group B), and 29 cases underwent conventional procedures without BAE (group C). Tumor size, procedure duration, dissection speed, en bloc resection rate, histology, and associated complications were compared between groups.ResultsThe mean tumor size, tumor invasiveness, fibrosis, and complications did not differ between groups. Although the en bloc resection rate did not differ (both 98%), the groups significantly differed with regard to the R0 resection rate (B: 96%; C: 83%; P = 0.048). Overall, the procedure duration (B: 51 min; C: 70 min; P = 0.17) and dissection speed (B: 19.4 mm2/min; C: 17.4 mm2/min; P = 0.13) were not significantly different between groups. However, the dissection speed for lesions in the cecum/ascending colon was significantly faster in group B than in group C (B: 22.3 mm2/min; C: 11.3 mm2/min; P = 0.037).ConclusionsIn cases of colorectal ESD with poor maneuverability, the use of BAE contributed to an improvement in the R0 resection rate. In addition, BAE contributed to a quicker dissection speed for lesions located in the cecum/ascending colon.
Sequential Intramolecular Diels–Alder Reaction of 3‐Heteroaryl‐2‐propenylamides of Ethenetricarboxylate
Authors: Sugiura Hirotaka , Yamazaki Shoko , Ogawa Akiya 
Published: August 2019

The reaction of 1,1,2‐ethenetricarboxylic acid 1,1‐diethyl ester with E‐3‐(2‐furyl)‐2‐propenylamines under the amide condensation conditions (EDCI/HOBt/Et3N) on heating at 80–110°C afforded cis‐fused tricyclic compounds, furo[2,3‐f]isoindoles as major product. On the other hand, the reaction with E‐3‐(3‐furyl)‐2‐propenylamines afforded trans‐fused tricyclic compounds predominantly. The formation of amide/[4 + 2] cycloaddition/hydrogen‐shift reactions proceed sequentially. The observed stereoselectivity of the fused rings has been investigated by the density functional theory calculations. The reaction of 1,1,2‐ethenetricarboxylic acid 1,1‐diethyl ester with 3‐(3‐pyridinyl)‐2‐propen‐1‐amine under the amide condensation conditions afforded HOBt‐incorporated 3,4‐trans‐pyrrolidine selectively. The chemoselectivity and stereoselectivity of the reactions with (3‐heteroaryl)‐2‐propen‐1‐amines depend on the nature of heteroarenes.
Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017
Authors: Ruffieux Yann , Lemsalu Liis , Aebi‐Popp Karoline , Calmy Alexandra , Cavassini Matthias , Fux Christoph A , Günthard Huldrych F , Marzolini Catia , Scherrer Alexandra , Vernazza Pietro , Keiser Olivia , Egger Matthias ,   the Swiss HIV Cohort Study and the Swiss National Cohort
Published: August 2019

AbstractIntroductionIn many countries, mortality due to suicide is higher among people living with HIV than in the general population. We aimed to analyse trends in suicide mortality before and after the introduction of triple combination antiretroviral therapy (cART), and to identify risk factors associated with death from suicide in Switzerland.MethodsWe analysed data from the Swiss HIV Cohort Study from the pre‐cART (1988‐1995), earlier cART (1996‐2008) and later cART (2009‐2017) eras. We used multivariable Cox regression to assess risk factors for death due to suicide in the ART era and computed standardized mortality ratios (SMRs) to compare mortality rates due to suicide among persons living with HIV with the general population living in Switzerland, using data from the Swiss National Cohort.Results and DiscussionWe included 20,136 persons living with HIV, of whom 204 (1.0%) died by suicide. In men, SMRs for suicide declined from 12.9 (95% CI 10.4‐16.0) in the pre‐cART era to 2.4 (95% CI 1.2‐5.1) in the earlier cART and 3.1 (95% CI 2.3‐4.3) in the later cART era. In women, the corresponding ratios declined from 14.2 (95% CI 7.9‐25.7) to 10.2 (3.8‐27.1) and to 3.3 (95% CI 1.5‐7.4). Factors associated with death due to suicide included gender (adjusted hazard ratio 0.58 (95% CI 0.38‐0.87) comparing women with men), nationality (1.95 (95% CI 1.34‐2.83) comparing Swiss with other), Centers for Disease Control and Prevention clinical stage (0.33 (95% CI 0.24‐0.46) comparing stage A with C), transmission group (2.64 (95% CI 1.71‐4.09) for injection drug use and 2.10 (95% CI 1.36‐3.24) for sex between men compared to other), and mental health (2.32 (95% CI 1.71‐3.14) for a history of psychiatric treatment vs. no history). There was no association with age.ConclusionsSuicide rates have decreased substantially among people living with HIV in the last three decades but have remained about three times higher than in the general population since the introduction of cART. Continued emphasis on suicide prevention among men and women living with HIV is important.
Colobine forestomach anatomy and diet
Authors: Matsuda Ikki , Chapman Colin A. , Clauss Marcus 
Published: August 2019

AbstractColobine monkeys have complex, multichambered, foregut‐fermenting stomachs with either three (“tripartite”) or four (“quadripartite,” adding the praesaccus) chambers where a commensal microbiome digests plant cell walls and possibly detoxifies defensive plant chemicals. Although different potential functions for the praesaccus have been suggested, little evidence exists to support any of the proposed functions. To address the issue of the function of the praesaccus, we collated literature data on diet and compared tripartite and quadripartite species. Our results suggest that the praesaccus is an adaptation to a dietary niche with a particularly high reliance on leaves as fallback foods in colobine clades with quadripartite stomachs, and a higher reliance on fruits/seeds as foods at times of high fruit availability in clades with tripartite stomachs. This supports the notion that a large gut capacity is an important characteristic by which folivores survive on a high fiber diet, and that this large gut capacity may not be necessary for some species if there are seasonal peaks in fruit availability.
Role of the non‐hypervariable FR3 D‐E loop in single‐domain antibody recognition of haptens and carbohydrates
Authors: Henry Kevin A. , Hussack Greg , Kumaran Jyothi , Gilbert Michel , MacKenzie C. Roger , Sulea Traian , Arbabi‐Ghahroudi Mehdi 
Published: August 2019

AbstractSingle‐domain antibodies (sdAbs), the variable domains of camelid heavy chain‐only antibodies, are generally thought to poorly recognize nonproteinaceous small molecules and carbohydrates in comparison with conventional antibodies. However, the structures of anti‐methotrexate, anti‐triclocarban and anti‐cortisol sdAbs revealed unexpected contributions of the non‐hypervariable “CDR4” loop, formed between β‐strands D and E of framework region 3, in binding. Here, we investigated the potential role of CDR4 in sdAb binding to a hapten, 15‐acetyl‐deoxynivalenol (15‐AcDON), and to carbohydrates. We constructed and panned a phage‐displayed library in which CDR4 of the 15‐AcDON‐specific sdAb, NAT‐267, was extended and randomized. From this library, we identified one sdAb, MA‐232, bearing a 14‐residue insertion in CDR4 and showing improved binding to 15‐AcDON by ELISA and surface plasmon resonance. On the basis of these results, we constructed a second set of phage‐displayed libraries in which the CDR4 and other regions of three hapten‐ or carbohydrate‐binding sdAbs were diversified. With the goal of identifying sdAbs with novel glycan‐binding specificities, we panned the library against four tumor‐associated carbohydrate antigens but were unable to enrich binding phages. Thus, we conclude that while CDR4 may play a role in binding of some rare hapten‐specific sdAbs, diversifying this region through molecular engineering is probably not a general solution to sdAb carbohydrate recognition in the absence of a paired VL domain.
Glymphatic imaging using MRI
Authors: Taoka Toshiaki , Naganawa Shinji 
Published: August 2019

In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system is hypothesized to be a waste clearance system of the CSF through the perivascular and interstitial spaces in the brain. Tracer studies have primarily been used to visualize or evaluate the waste clearance system in the brain, and evidence for this system has accumulated. The initial study that identified the glymphatic system was an in vivo tracer study in mice. In that study, fluorescent tracers were injected into the cisterna magna and visualized by two‐photon microscopy. MRI has also been used to evaluate glymphatic function primarily with gadolinium‐based contrast agents (GBCAs) as tracers. A number of GBCA studies evaluating glymphatic function have been conducted using either intrathecal or intravenous injections. Stable isotopes, such as 17O‐labeled water, may also be used as tracers since they can be detected by MRI. In addition to tracer studies, several other approaches have been used to evaluate ISF dynamics within the brain, including diffusion imaging. Phase contrast evaluation is a powerful method for visualizing flow within the CSF space. In order to evaluate the movement of water within tissue, diffusion‐weighted MRI represents another promising technique, and several studies have utilized diffusion techniques for the evaluation of the glymphatic system. This review will discuss the findings of these diffusion studies.Level of Evidence: 5Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;51:11–24.