bluuebunny/crossref_metadata_2025_split huggingface dataset:
ФІЗИЧНА ТЕРАПІЯ СПОРТСМЕНІВ ІГРОВИХ ВИДІВ СПОРТУ ПІСЛЯ АРТРОСКОПІЧНОГО ЛІКУВАННЯ ТРАВМ КОЛІННОГО СУГЛОБА
Authors: ОДИНЕЦЬ Тетяна , БАНДУРІНА Катерина , ШЕВЧЕНКО Ельдар 
Published: November 2024

Травми колінного суглоба є однією з найпоширеніших проблем серед спортсменів ігрових видів спорту, таких як футбол, баскетбол, гандбол та волейбол. Враховуючи високі навантаження на опорно-руховий апарат під час швидких переміщень, стрибків і раптових змін напрямку руху, спортсмени цих видів часто зазнають пошкоджень структур коліна, включаючи меніски, зв'язки та хрящі. Мета дослідження: розробити програму поліпшення функціонального стану колінного суглоба у спортсменів ігрових видів спорту після артроскопічного лікування та експериментально оцінити її ефективність. Методи дослідження. В роботі були застосовані методи теоретичного рівня дослідження: аналіз, порівняння, індукція, дедукція, систематизація та узагальнення науково-методичної літератури, педагогічний експеримент, медико-біологічні методи, методи математичної статистики. Результати роботи. Наприкінці дослідження показник згинання колінного суглоба у спортсменів основної групи був істотно вищим порівняно з контрольною групою на 25,74 градуса (р<0,001), а розгинання – на 14,30 градусів (р<0,001). У контрольній групі зміни сили згиначів колінного суглоба не були статистично значущими, з покращенням на 0,35 бала (р>0,05), тоді як сила розгиначів зросла на 0,25 бала (р>0,05). В основній групі спостерігалося достовірне поліпшення сили згиначів колінного суглоба на 1,82 бала (р<0,001), а сила розгиначів – на 1,90 бала (р<0,001). Наприкінці дослідження після операції больові відчуття в обох групах стали близькими до нормальних показників, однак в основній групі рівень больового синдрому був достовірно нижчим, ніж у контрольній. Висновки. Таким чином, Результати дослідження свідчать про важливість застосування спеціалізованих програм фізичної реабілітації для досягнення оптимальних результатів у відновленні спортсменів після артроскопічних операцій.
Research on Ways to Enhance Regional Economic Competitiveness Based on the Perspective of Business Management
Authors: Zhai Yajing 
Published: November 2024

Regional economic competitiveness is an important index to measure the level of economic development and market attraction of a region, which covers many dimensions such as economic strength and industrial development. Business management plays a key role in enhancing regional economic competitiveness. By optimizing industrial structure, promoting enterprise innovation and improving the quality of human resources, business management can effectively promote the overall development of regional economy. This paper discusses the ways to enhance regional economic competitiveness based on the perspective of business management, including formulating scientific regional development strategy, strengthening enterprise management, optimizing human resource management and so on.
Biochemical Composition of Pila Globosa (Swainson: Gastropod) in Active and Aestivation Periods
Authors: Shathi Umme Habiba , Rahman Md Redwanur 
Published: November 2024

This research looks at the biochemical makeup of the edible gastropod Pila globosa, which is found in freshwater. One of Bangladesh's largest beels, Chalan Beel, is where this investigation was conducted for analyze the nutritional value of this snail. In freshwater snails, seasonal variations in biochemical composition, including protein, fat, and ash, have been observed during two distinct periods: the Active period and the Aestivation period. On body meat, this analysis was conducted. The Micro-Kjeldahl distillation method was used to evaluate the protein content. There were no seasonal variations in the body’s edible water content. Significant seasonal fluctuations were seen in other edible portion components, though. It was discovered that throughout both the active and aestivation periods, the edible portions had a high protein proportion. The range of the calorific value (including ash) was 7.83 to 11.98%. Seasonal variations were seen in the edible body part's fat and carbohydrate composition. It was discovered that throughout both the active and aestivation periods, the edible portions had a high protein proportion which can help to alleviate nutrient deficiencies.
Bangladesh J. Zool. 52(2): 263-270, 2024
Epitope-based therapeutic targets in HCV genotype 1 non-structural proteins: a novel strategy to combat emerging drug resistance
Authors: Tudi Mireayi , Sawuti Adili , Abudurusuli Maimaitituerhong , Wu Chao , Chen Xiaoyu , Ailimu Gulimire , Wulayin Kuerbannisa , Tuerxun Maimaitiaili 
Published: November 2024

IntroductionThe hepatitis C virus (HCV) poses a major global health challenge, with its non-structural proteins being essential for viral replication and pathogenesis. Mutations in these proteins significantly contribute to drug resistance, necessitating innovative therapeutic strategies. This study aims to identify epitope-based therapeutic targets in the non-structural proteins of HCV genotype 1, employing in-depth in silico tools to counteract emerging drug resistance.MethodsWe retrieved approximately 250 sequences of each non-structural protein from the NCBI database, capturing a broad spectrum of variability and sequence alignments, variability analysis and physicochemical property analysis were conducted. We utilized the TEPITOOL server by IEDB to predict cytotoxic T lymphocyte (CTL) epitopes. Following this, we assessed the efficiency of TAP transport and proteasomal cleavage using IEDB’s combined predictor tool. The epitopes were selected based on conservancy analysis, immunogenicity, allergenicity, and presence in non-glycosylated regions, ensuring high predictive scores and suitability as vaccine candidates. Epitopes were docked with the HLA-A*02:01 allele and Toll-like receptor-3 using the ClusPro server. The immune response potential of the epitopes was evaluated through in-silico immune stimulation.ResultsThe study identified 27 potential CTL epitopes from the non-structural proteins, including NS3, NS4a, NS4b, NS5a, and NS5b. Out of these, three lead epitopes demonstrated high conservation (&gt;90%), strong binding affinities to HLA-A*02:01 and TLR-3, and robust immune response potential. These epitopes also showed favorable characteristics such as being non-allergenic and non-glycosylated.ConclusionThis comprehensive in-silico analysis provides a promising foundation for developing an epitope-based vaccine targeting HCV non-structural proteins, offering a novel approach to overcoming drug resistance in HCV treatment.
Sex related disparities after complex percutaneous coronary interventions
Authors: Alperi Alberto , Almendárez Marcel , Pascual Isaac , Alvarez Rut , Betanzos Jose Luis , Hernández-Vaquero Daniel , Ptaszynski Raul , Ortiz Juan Francisco , Moris Cesar , Avanzas Pablo 
Published: November 2024

IntroductionComplex Percutaneous coronary intervention (PCI) for the treatment of ischemic heart disease has increased significantly. We aimed to evaluate sex-related differences in patients undergoing complex PCI.Methodssingle-center prospective observational study including patients undergoing complex PCI between 2017 and 2023. Baseline and procedural features, and mid-term outcomes were compared according to the gender distribution. The combined primary endpoint included stroke, myocardial infarction, need for a new coronary revascularization, and all-cause mortality. Propensity score (PS) matching with an inverse probability of treatment weight (IPW) approach was used to adjust for differences in baseline characteristics.Results1,283 patients were included, 983 (76.6%) male and 300 (23.4%) female. Median follow-up was 2.4 (IQR: 1–3.8) years. There was a higher rate of no-reflow phenomenon (4% vs. 1.8%, p = 0.03) among female patients. In the overall cohort, female patients had a greater risk for the combined primary endpoint (HR 1.28, 95% CI: 1.02–1.59). In the matched cohort, female patients exhibited a higher risk for the combined primary endpoint (HR 1.23, 95% CI: 1.06–1.42), as well as for myocardial infarction (HR 1.34, 95% CI 1.03–1.75), and all-cause mortality (HR 1.21, 95% CI 1.02–1.45), and a trend towards a higher risk for the need of a new coronary revascularization (HR 1.22, 95% CI 0.92–1.61).Conclusionsin a contemporary cohort of patients undergoing complex PCI procedures, female patients are associated with a higher risk of early complications.
Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity
Authors: Castañer O. , Pérez-Vega K. A. , Álvarez S. , Vázquez S. , Casajoana A. , Blanchart G. , Gaixas S. , Schröder H. , Zomeño M. D. , Subirana I. , Muñoz-Aguayo D. , Fitó M. , Benaiges D. , Goday A. , Oliveras A. 
Published: November 2024

BackgroundBariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality.AimTo assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in patients with severe obesity undergoing BS.MethodsA prospective observational study within a cohort of consecutively enrolled patients with severe obesity scheduled to undergo BS. In total, 62 participants (77% women), with a mean age of 42.1 years (SD 9.33 years) underwent BS. Regarding the surgical procedure, 27 (43.5%) underwent sleeve gastrectomy and 35 (56.5%) Roux-en-Y gastric bypass. All patients were evaluated preoperatively and at 1, 3, 6, and 12 months after surgery.ResultsA decrease in body mass index and an improvement in the systemic lipid profile, indicated by reductions in total cholesterol, low-density lipoprotein cholesterol (LDLc), and remnant cholesterol, and an increase in HDL cholesterol (HDLc) was observed (all p trend &lt; 0.001). Time-series comparisons vs. baseline showed that, in general, anthropometric measures, glycemia, total cholesterol, LDLc, and remnant cholesterol decreased at all follow-ups, whereas HDLc and triglyceride concentrations significantly improved vs. baseline from 6 months, reaching at 12 months the highest HDLc levels (29.6%, p &lt; 0.001) and the lowest circulating triglycerides (−30%, p &lt; 0.001). Although HDL's anti-inflammatory ability worsens after surgery, the HDL-mediated CEC linearly increased after surgery (for both p trend &lt; 0.013).ConclusionBS improves the lipid profile both quantitatively and qualitatively after 1 year, specifically enhancing HDL-mediated cholesterol efflux capacity, which may contribute to a reduced cardiovascular risk in individuals with severe obesity.
Glycemic profile variability as an independent predictor of diabetic retinopathy in patients with type 2 diabetes: a prospective cohort study
Authors: Dehghani Firouzabadi Fatemeh , Poopak Amirhossein , Samimi Sahar , Deravi Niloofar , Nakhaei Pooria , Sheikhy Ali , Moosaie Fatemeh , Rabizadeh Soghra , Meysamie Alipasha , Nakhjavani Manouchehr , Esteghamati Alireza 
Published: November 2024

BackgroundGlycemic variability is a novel predictor for diabetic complications. Different studies have demonstrated contradictory results for the association between HbA1c variability and diabetic retinopathy. We aimed to assess the relationship between visit-to-visit variability in glycemic profile (HbA1c, 2hPP, and FBS) and diabetic retinopathy.MethodsPatients with type 2 diabetes were monitored for the development of retinopathy for 10 years. The association between the incidence of retinopathy and glycemic variability was assessed via Cox regression analysis, and coefficient of variation for glycemic indices was compared using independent sample t-test.ResultsPatients with diabetic retinopathy had significantly higher glycemic profile variability. The incidence of retinopathy was positively correlated with cv-FBS10% (10% of coefficient of variance), cv-FBS20%, cv-2hpp10%, and cv-HbA1c5%. Our analysis revealed that the higher variability of FBS increased the incidence and progression of retinopathy (HR: 12.29, p-value = 0.003).ConclusionOur findings demonstrated glycemic profile variability as an independent risk factor for diabetic retinopathy in patients with type 2 diabetes and support glycemic profile variability measurement in addition to common glycemic parameters to improve risk stratification in patients with type 2 diabetes. Further investigation is required to demonstrate the long-term effects of alleviating glycemic variability on the prognosis of patients with type 2 diabetes.
Association of weight-adjusted waist index with all-cause and cause-specific mortality among cancer survivors: a cohort study of the NHANES 1999-2018
Authors: Li Shi , Jin Jing , Zhang Wenshun , Cao Ying , Qin Haiyun , Wang Jianguang , Yu Jiaxiang , Wang Wenping 
Published: November 2024

BackgroundObesity is becoming more widely acknowledged as a chronic illness that raises the risk of oncogenesis. This inquiry aimed to look into the correlation between cancer patient mortality and obesity, as measured by the weight-adjusted waist index (WWI).MethodsWe used continuous data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 as the benchmark, with a follow-up validity period of December 31, 2019. First, we assessed the correlation between WWI and the all-cause and cause-specific execution of cancer sufferers using multivariable Cox proportional hazards models. Second, a smoothed curve fit was utilized to examine the relationship between WWI and both cause-specific and all-cause mortality in cancer patients. Lastly, we analyzed the relationship between WWI and both cause-specific and all-cause mortality in cancer patients, to find out if this link held across the population subgroup evaluation and impact analyses were used as well during the last step.ResultsWith a median follow-up of 87.8 months, 1,547 (34.7%) of the 4,463 cancer patients had deceased. Among them, 508 (11.4%) succumbed to cancer, while 322 (7.2%) passed away due to cardiovascular disease. Multivariate Cox proportional hazards model of mortality among cancer patients revealed an all-cause mortality hazard ratio [HR=1.13; 95% CI (1.04, 1.23)] and cardiovascular mortality [HR=1.39; 95% CI (1.16, 1.67)]. Furthermore, for each unit increase in WWI, all-cause mortality was significantly higher in male cancer survivors than in female cancer survivors.ConclusionsOur study reveals substantial correlations between WWI and all-cause and cardiovascular mortality in US cancer survivors, helping to identify cancer survivors at higher risk of death and thus potentially guiding targeted interventions.
Analysis of factors influencing prevalence and malignancy of thyroid nodules in various iodine uptake areas
Authors: Xie HongLei , Pan HaoWen , Qian TingTing , Hou Xin , Zhao Meng , Che WenJing , Li WeiDong , Xu Xian , Su Yue , Li Jia , Yue ZongYu , Zhang ZeXu , Liu Peng 
Published: November 2024

BackgroundThe prevalence of thyroid nodules (TNs) has been increasing rapidly. However, little is known about the drivers of its high prevalence and tendency of malignancy. This study aimed to analyze the factors influencing the prevalence and malignancy of TNs in the adult population.MethodsA multi-stage stratified cluster random sampling was used to conduct a cross-sectional survey of the population in different iodine uptake areas in Anhui Province. The areas with deficient, adequate, and excess iodine intake were grouped according to population's urine iodine. A questionnaire, laboratory examination and ultrasound diagnosis were conducted on the participants. Nodules were diagnosed and distinguished using ultrasonography. Spearman rank correlation, random forest importance ranking, ROC curve, and unconditional binary logistic regression analyses were used to screen for risk factors.ResultsA total of 1,697 participants (539 males and 1,158 females) aged 18–60 years were included, 355 of whom were diagnosed with TN. The prevalence of TNs was 20.9% and varied in different areas, with 21.9%, 25.8%, and 18.0% in the iodine deficient, adequate, and iodine excess areas, respectively. The prevalence of TNs in females was significantly higher than that in males (24.5% vs. 13.2%) and it increased with age. Female sex (OR, 1.67 [1.21–2.30]), old age (&gt;41 years, OR, 2.00 [1.14, 3.50]) and smoking were risk factors for the development and deterioration of TNs.ConclusionsPatients with TNs should exercise caution when consuming goitrogens and adhere to a scientifically balanced diet. Given the high incidence of TNs in field setting, it is necessary to raise public health awareness among residents and perform regular thyroid ultrasound screening to facilitate early detection and treatment.
Unveiling the hidden risks: albumin-corrected anion gap as a superior marker for cardiovascular mortality in type 2 diabetes: insights from a nationally prospective cohort study
Authors: Wang Mingsi , Yang Shu , Deng Jingwen , Wu Dehai , He Changzhi , Li Guanghua , Dong Ying , Zhang Yongxiang , Li Yilan 
Published: November 2024

AimsHypoalbuminemia can lead to underestimations of the true anion gap levels. There are few data on albumin-corrected serum anion gap (ACAG) status and mortality in the diabetes. The study aimed to examine the association between ACAG and all-cause, cardiovascular, and cancer mortality in type 2 diabetes (T2D) patients.MethodsHerein, 8,161 diabetic adults were included in the National Health and Nutrition Examination Survey (NHANES) 1999-2018. National Mortality Index (NDI) data were used for determining mortality outcomes through 31 December 2019. Cox proportional hazards models were used to estimate the risk of all-cause, cardiovascular, and cancer mortality. We conducted a mediation analysis using the counterfactual framework method to estimate how ACAG may be indirectly associated with increased mortality risk through mediators.ResultsA total of 2,309 deaths were documented over 8,161 person-years of follow up, including 659 cardiovascular and 399 cancer deaths. In multivariate analyses, higher ACAG levels had a significant correlation with an increase in all-cause (HR, 1.58; 95% CI, 1.38-1.81; P=0.001), cardiovascular (HR, 1.34; 95% CI, 1.05-1.72; P=0.019), and cancer (HR, 1.41; 95% CI, 1.02-1.96; P=0.018) mortality rates than the controls. Results of the mediation analysis showed that altered levels of C-reactive protein and estimated glomerular filtration rate (eGFR) explained 7.867% and 7.669% of the relation between serum ACAG and all-cause mortality, respectively (all P&lt;0.05). Total cholesterol and HbA1c mediated 15.402% and 14.303% of the associations with cardiovascular mortality, respectively (all P&lt;0.05).ConclusionsHigher ACAG levels were significantly associated with increased all-cause, cardiovascular, and cancer mortality. Researchers suggest that patients with T2D who control ACAG in a normal state may be at a lower risk of mortality.
Bone metastasis in differentiated thyroid cancer: Spanish multicenter study of clinical characteristics, survival and prognostic factors
Authors: Dueñas-Disotuar Suset , Piñar-Gutiérrez Ana , de Lara-Rodríguez Irene , Sastre-Marcos Julia , Anda-Apiñániz Emma , Oleaga-Alday Amelia , Galofré JC , Orois Aida , Alcázar-Lázaro Victoria , Martínez-Guasch Laia , Sánchez-Ragnarsson Cecilia , Gálvez-Moreno María Ángeles , Familiar-Casado Cristina , Martín-Hernández Tomás , Romero-Lluch Ana R. 
Published: November 2024

ObjectiveThis study describes the characteristics, survival and prognostic factors in a cohort of patients with bone metastases (BM) from differentiated thyroid carcinoma (DTC).MethodsThis was a multicenter retrospective observational study conducted in Spain, including patients diagnosed with DTC and BM between 1980 and 2022. A Cox regression analysis was performed to examine prognostic factors for survival. Kaplan-Meier and log-rank tests were performed for survival analysis and comparison between groups.ResultsA total of 133 patients were included with a median follow-up of 40 (17-70) months. Seventy patients (52.6%) had BM at the initial diagnosis. Fifty-two (39.1%) had follicular carcinoma. Sixty-six (49.6%) presented multiple BM. The most frequent location was the spine (63.2%). Other metastases were present at diagnosis in 88 (66.2%), mainly lung (60.9%). BM were treated with I131 in 91 (68.4%) patients, with BM uptake in 63 (47.4%). Fifty-six (42.1%) received treatment with multikinase inhibitors. Fifty-three (3.9%) had skeletal-related events. Seventy-two (54.1%) died. The 3-, 5- and 10-year survival was 53.5, 39.5% and 28.5%, respectively. Significant prognostic factors in the multivariate analysis were the presence of lymph node metastases (N1) HR 1.71 (95% CI 1.005-2.098; p=0.048), BM treatment with I131 HR 0.532 (95% CI 0.304-0.931; p=0.027) and age ≥67 years at BM diagnosis HR 1.991 (95% CI 1.142-3.47; p=0.015).ConclusionsSurvival of DTC patients with BM treated in a Spanish cohort was 39.5% at 5 years and 28.5% at 10 years. Patients with BM treated with I131 appear to have a better outcome in terms of mortality and the presence of lymph node involvement and age over 67 years were associated with higher mortality.
A particular focus on the prevalence of α-thalassemia and β-thalassemia among pregnant women in Changsha County, Hunan Province
Authors: Xia Yu , Huang Cailian , Yang Mudan , Zhang Meng , Lu Yang 
Published: November 2024

BackgroundThalassemia is a inherited monogenic blood disorder and more prevalent in southern China. In this study, Our aim was to elucidate the molecular spectrum and phenotypic features of thalassemia in pregnant women in Changsha County.MethodsNext-generation sequencing (NGS) was conducted for 38,810 pregnant women to diagnose thalassemia in Changsha County. Further analysis of hematological parameters was conducted on subjects who had not previously undergone thalassemia screening in other hospitals.ResultsIn this study, 2,208 (5.69%) pregnant women were diagnosed as carriers of thalassemia using NGS analysis. Among 1,594 cases of α-thalassemia, 23 genotypes were identified, and among 578 cases of β-thalassemia, 22 genotypes were detected. Additionally, 18 genotypes were detected among 36 cases of composite α- and β-thalassemia. Among all carriers of thalassemia, 8 rare α-mutations and 11 rare β-mutations were found in the study population. Notably, pregnant women diagnosed as carriers of thalassemia tended to have lower hemoglobin levels. Furthermore, multivariable logistic regression analysis indicates that the values of MCV and MCH have the greatest impact on genetic diagnosis.ConclusionOur study has provided detailed genotypes and hematological parameters of thalassemia in pregnant women in Changsha county and reveal that certain abnormal blood parameters have a remarkably impact on genetic diagnosis results. Furthermore, our data suggest that combining hemoglobin electrophoresis and NGS provides a powerful tool for prenatal diagnosis, which will increase the accuracy of clinical diagnosis of thalassemia.