bluuebunny/crossref_metadata_2025_split huggingface dataset:
Divide to unite
Authors: van Bijnen Emma , Greco Sara 
Published: February 2019

Abstract
In dispute mediation, mediators, perhaps counterintuitively, make the disagreement between parties explicit and
formulate their interventions on the disagreement in such a way that the disagreement is made manageable. In this paper, three
functions of identifying and elucidating the parties’ disagreement that demonstrate the importance of making disagreement
salient – (1) uncovering real issues, (2) emphasizing conflict ownership, (3) making disagreements manageable – are presented.
Corpora of mediation simulation transcripts are used as empirical bases for the analyses of the means by which mediators make
disagreement explicit (the how) and for what specific functions they do so (the why). The three aspects of strategic maneuvering
(van Eemeren 2010) are used to analyze how mediators construct the interventions on
the disagreement in terms of: (a) the topics they select from the topical potential, (b) the adjustment of interventions to suit
their intended addressee(s), and (c) what presentational devices are used.
A predictive coding approach to Text World Theory
Authors: Neurohr Benedict 
Published: February 2019

Abstract
Text World Theory offers a beneficial tool for the analysis of texts and the structures of fictional worlds. A significant and fascinating topic is the cognitive and psychological reality behind the text-world structures identified by an expert researcher of literature and if they are experienced when read by a given individual for pleasure. Using a neurological model of perceptual processing called Predictive Coding, this chapter sets out to examine how a text might be processed in real time by a reader. This process must also be sensitive to readers’ prior knowledge in keeping with Text World Theory, and whether it is the first time the text is read or not. It will be shown that while the analyses provided by Text World Theory are valid and useful for describing fictional constructions, it is possible to be even more precise when describing the formation of text-worlds in a real-time reading process.
Experiencing horrible worlds
Authors: Stewart-Shaw Lizzie 
Published: February 2019

Abstract
In this chapter, I explore how conceptual movement within the fictional worlds of horror can affect the reader’s emotional experience of the text. I argue that horror fiction necessarily requires “horrible” world-building elements and function-advancing propositions to establish the macabre ambience of the fictional world, which contributes to the reader’s experience of negative emotions such as anxiety and fear. Once this uncomfortable world is established, various types of world creation can manipulate the reader’s attention to bring about such negative emotional responses. Drawing on Text World Theory (Gavins 2007) and attention and resonance (Stockwell 2009a) to investigate this phenomenon, I conduct a stylistic analysis of how the text-worlds of Stephen King’s IT (1986) are built and experienced by readers.
Sharing fiction
Authors: Jackson Sarah 
Published: February 2019

Abstract
In this chapter, I explore the pre-adult reading experience and assess what pre-school literary interaction can tell us about later adult literary cognition and the subjective experience of reading fiction. The cognitive-linguistic framework Text World Theory is applied to storytime discourse in order to examine the complexities of early reading practices. Throughout this chapter, I advocate an empirical approach to the examination of the pre-school reading experience and the discussion centres on data collected from real readers: specifically, reader dyads made up of a pre-school child aged between two and four years old and a parent, who regularly read a picture-book story together at home. The analysis presented in this chapter focuses on the storytime discourse of one of my adult–child pair participants, and looks specifically at the role of “interactive interpretation” and pictures on the pre-schooler’s literary experience. Overall, I argue that participants work together during storytime to negotiate meaning and assimilate their independent text-worlds for a coherent literary experience.
Stem alternations in the Brag-bar dialect of Situ Rgyalrong
Authors: Zhang Shuya 
Published: February 2019

AbstractIn Rgyalrongic studies, it is believed that the most complex stem alternation system is found in Zbu, a Northern Rgyalrong language, whereas other languages, including Situ, have simpler systems. However, as a dialect of Situ Rgyalrong, Brag-bar presents a complex stem alternation system exhibiting several opaque features in comparison with other Situ dialects. This paper documents the stem alternations in the Brag-bar dialect of Situ Rgyalrong. It first describes the distribution and stem formation devices of different verb stems in Brag-bar, then explains the occurrence of the irregular stem I′/II′ in Brag-bar and investigates their synchronic status.
The synchronic and diachronic phonology of Va
Authors: Sun Jackson T. -S. 
Published: February 2019

AbstractVa, an obscure language of Southwestern Yunnan, belongs to the Wa-Lawa cluster under the Waic subgroup of Palaungic in the Austroasiatic language family. This article presents an overview of Va synchronic phonology and an account of its evolution from the Proto-Wa-Lawa sound system reconstructed by Gérard Diffloth. Modern Va phonology is characterized by fully monosyllabic word structure, reduced syllable canon, and a robust three-tone system. Its atypical phonological profile from an Austroasiatic perspective and its tonogenesis may be directly attributed to the sociolinguistic ambience of the Va-speaking areas. The phonological innovations discussed herein, including onset-driven tone splitting rules and coda-driven vowel splitting rules, will help determine the language’s distinct status within the Wa-Lawa language cluster.
Commodification, vulnerability, risk: gendered social policy developments in the United States, 1980–2018
Authors: Laperrière Marie , Orloff Ann Shola , Pryma Jane 
Published: February 2019

AbstractOver the last few decades, the position of women vis-à-vis the welfare state has changed dramatically. Welfare states have adapted to women's increased labour force participation and to the “new social risks” that characterize postindustrial societies. In this paper, we examine gendered policy developments in the US, focusing on conceptions of vulnerability that inform policies meant to mitigate gendered social risks. Focusing on three policy areas: parental leave, domestic violence and disability, we show that policies increasingly target women's integration into the workforce and self-regulation as strategies to mitigate gendered social risk. We also discuss how these policies rely on individual interventions implemented by what we call punitive therapy practitioners, who encourage women's workforce participation and psychological self-regulation. Finally, we argue that enduring gendered conceptions of vulnerability have shaped the specific designs of policies that emerged in the 1960s–1970s, intensified through the 1980s, 1990s, and early 2000s, and persist today.
Nondipping Pattern and Cardiovascular and Renal Damage in a Population-Based Study (The STANISLAS Cohort Study)
Authors: Lopez-Sublet Marilucy , Girerd Nicolas , Bozec Erwan , Machu Jean-Loup , Ferreira João Pedro , Zannad Faiez , Mourad Jean-Jacques , Rossignol Patrick 
Published: February 2019

Abstract

OBJECTIVE
The attenuation of physiological nocturnal decline of blood pressure (BP)—called nondipper pattern—has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. This study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study.

METHODS
The STANISLAS Cohort is a single-center, familial longitudinal cohort composed of 1,006 families (4,295 subjects) recruited in 1993–1995 for a 5-year periodic health examination. A total of 1,334 subjects from the 4th visit (2011–2016) of the STANISLAS cohort were included. This 4th examination included estimated glomerular filtration rate, albumin/creatinine ratio, pulse wave velocity, central systolic BP, carotid intima–media thickness and distensibility, left ventricular mass index, left ventricular hypertrophy, diastolic dysfunction, and ambulatory blood pressure monitoring (ABPM). Nondipping status was defined as a mean reduction in systolic BP (SBP) or diastolic BP (DBP) lower than 10% during nighttime.

RESULTS
Data were obtained from 798 normotensive subjects (45 ± 14 years, 395 [49%] nondippers, SBP/DBP mmHg 24 hours: 116/71 ± 7/5) and 536 hypertensive patients (56 ± 11 years, 257 [48%] nondippers, SBP/DBP mmHg 24 hours: 127/78 ± 10/7). Mean 24-hour and daytime ABPM measurements were within the normal range, even in hypertensive participants (19% treated). The nondipping pattern was not associated with cardiovascular or renal alterations in this population.

CONCLUSION
In this middle-aged population with an overall 24-hour optimal BP control, the nondipper pattern was not associated with increased cardiovascular or renal damage.
Assembly Graph Browser: interactive visualization of assembly graphs
Authors: Mikheenko Alla , Kolmogorov Mikhail 
Published: February 2019

Abstract

Summary
Currently, most genome assembly projects focus on contigs and scaffolds rather than assembly graphs that provide a more comprehensive representation of an assembly. Since interactive visualization of large assembly graphs remains an open problem, we developed an Assembly Graph Browser (AGB) tool that visualizes large assembly graphs, extending the functionality of previously developed visualization approaches. Assembly Graph Browser includes a number of novel functions including repeat analysis, construction of the contracted assembly graphs (i.e. the graphs obtained by collapsing a selected set of edges) and a new approach to visualizing large assembly graphs.

Availability and implementation
http://www.github.com/almiheenko/AGB.

Supplementary information
Supplementary data are available at Bioinformatics online.
SaGePhy: an improved phylogenetic simulation framework for gene and subgene evolution
Authors: Kundu Soumya , Bansal Mukul S 
Published: February 2019

Abstract

Summary
SaGePhy is a software package for improved phylogenetic simulation of gene and subgene evolution. SaGePhy can be used to generate species trees, gene trees and subgene or (protein) domain trees using a probabilistic birth–death process that allows for gene and subgene duplication, horizontal gene and subgene transfer and gene and subgene loss. SaGePhy implements a range of important features not found in other phylogenetic simulation frameworks/software. These include (i) simulation of subgene or domain level evolution inside one or more gene trees, (ii) simultaneous simulation of both additive and replacing horizontal gene/subgene transfers and (iii) probabilistic sampling of species tree and gene tree nodes, respectively, for gene- and domain-family birth. SaGePhy is open-source, platform independent and written in Java and Python.

Availability and implementation
Executables, source code (open-source under the revised BSD license) and a detailed manual are freely available from http://compbio.engr.uconn.edu/software/sagephy/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Rifampicin effect on intracellular and plasma pharmacokinetics of tenofovir alafenamide
Authors: Cerrone Maddalena , Alfarisi Omamah , Neary Megan , Marzinke Mark A , Parsons Teresa L , Owen Andrew , Maartens Gary , Pozniak Anton , Flexner Charles , Boffito Marta 
Published: February 2019

Abstract

Objectives
Tenofovir alafenamide produces lower plasma tenofovir and higher intracellular tenofovir diphosphate (DP) concentrations than tenofovir disoproxil fumarate but it is likely a victim of interactions with rifampicin. We aimed to investigate the pharmacokinetics of tenofovir alafenamide/emtricitabine with rifampicin.

Patients and methods
Healthy volunteers received tenofovir alafenamide/emtricitabine at 25/200 mg once daily, followed by tenofovir alafenamide/emtricitabine + rifampicin daily followed by tenofovir disoproxil fumarate. Plasma tenofovir alafenamide, tenofovir, emtricitabine and intracellular tenofovir-DP and emtricitabine triphosphate pharmacokinetics and genetic polymorphisms were assessed.

Results
Tenofovir alafenamide exposure decreased when tenofovir alafenamide/emtricitabine + rifampicin was used compared with tenofovir alafenamide/emtricitabine [geometric mean ratio (GMR) (90% CI): 0.45 (0.33–0.60)]. Plasma tenofovir and intracellular tenofovir-DP concentrations decreased with rifampicin [GMR (90% CI): 0.46 (0.40–0.52) and 0.64 (0.54–0.75), respectively]. GMR (90% CI) of intracellular tenofovir-DP AUC0–24 for tenofovir alafenamide/emtricitabine + rifampicin versus tenofovir disoproxil fumarate was 4.21 (2.98–5.95). Rifampicin did not affect emtricitabine pharmacokinetics. CYP3A4*22 rs35599367 was associated with higher plasma tenofovir alafenamide AUC0–24 at day 56.

Conclusions
Following tenofovir alafenamide/emtricitabine administration with rifampicin, intracellular tenofovir-DP concentrations were still 4.21-fold higher than those achieved by tenofovir disoproxil fumarate, supporting further study during HIV/TB co-infection.
Influence of Severity on Aesthetic Outcomes of Unilateral Cleft Lip Repair in 1,823 Patients
Authors: Campbell Alex , Restrepo Carolina , Park Eugene , Navas Genesis , Deshpande Gaurav , Swanson Jordan , Schonmeyr Bjorn , Wendby Lisa , Ayala Ruben 
Published: February 2019

Background:
Although efforts to improve access to care for patients with cleft lip in the developing world have grown tremendously, there is a dearth of data regarding aesthetic outcomes after cleft lip repairs in this setting. Defining severity-outcome relationships has the potential to improve efficiency of care delivery in resource-limited settings, and to improve overall results. In this study, we investigate the relationship between initial cleft lip severity and early aesthetic outcomes following surgical repair of primary unilateral cleft lip.

Methods:
Using previously validated tools to assess unilateral cleft lip severity and aesthetic outcome after repair, we evaluated 1,823 consecutive patients who underwent primary unilateral cleft lip/nose (UCL/N) repair. Three separate evaluators scored each case for a total of 5,469 total independent evaluations.

Results:
Our results show that with increasing severity of UCL/N deformity, there is a corresponding decrease in early aesthetic outcome scores. Using our results, we established normative early aesthetic outcomes following repair for each severity grade of UCL/N deformity.

Conclusions:
In conclusion, this study has achieved a standardized, timely, and cost-effective evaluation of 1,823 surgical cases of primary UCL/N repair. This data set provides a normal distribution of aesthetic results according to initial cleft severity and defines a standard of “expected” aesthetic results after primary UCL/N repair. Our results also show a clear correlation between initial severity and immediate aesthetic result after surgery, though we also show that excellent results are possible regardless of initial cleft severity.
Recent Advances in Antiemetics
Authors: Smith Carrie , Smith Michele , Cunningham Regina , Davis Susan 
Published: February 2019

Background:
Despite the availability of effective antiemetic regimens, patients still experience chemotherapy-induced nausea and vomiting (CINV). 5-Hydroxytryptamine 3 (5-HT3) receptor antagonists (RAs) are the mainstay of CINV prevention, and updated antiemetic guidelines include new options.

Objective:
The aim of this study was to highlight advances in CINV management, focusing on new 5-HT3 RA formulations in adults, updated antiemetic guidelines, and the role of nurses.

Methods:
MEDLINE searches were conducted for English-language publications for the past 15 years using relevant search terms (“serotonin receptor antagonist,” “5-HT3 receptor antagonist,” “antiemetic,” “chemotherapy-induced nausea and vomiting”) in the abstract or title. Abstracts at relevant major congresses for the past 3 years and additional pivotal publications were included. The most informative, relevant, and current publications were included.

Results:
5-Hydroxytryptamine 3 RAs are effective in preventing acute (0–24 hours) CINV but less effective in the delayed phase (24–120 hours) given their short half-lives. Updated antiemetic guidelines include fixed-dose intravenous fosnetupitant and palonosetron (IV NEPA) and granisetron extended-release subcutaneous injection, a recently approved 5-HT3 RA formulation providing slow, controlled release of therapeutic granisetron concentrations for 5 days or longer. Nurses play a pivotal role in implementing updated guideline-recommended antiemetic regimens for highly and some moderately emetogenic chemotherapy regimens, comprising a 4- or 3-drug regimen of 5-HT3 RA, neurokinin-1 RA, and dexamethasone, with/without olanzapine.

Conclusion:
Newer antiemetic combinations and formulations provide flexibility for CINV prevention. Granisetron extended-release subcutaneous injection is a convenient subcutaneous granisetron option.

Implications for Practice:
Nurses play a critical role in understanding and using new antiemetic formulations and updated antiemetic guidelines in their practices.
Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy
Authors: Hutch Chelsea R. , Trakimas Danielle R. , Roelofs Karen , Pressler Joshua , Sorrell Joyce , Cota Daniela , Obici Silvana , Sandoval Darleen A. 
Published: February 2019

Objective:
The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).

Summary Background Data:
OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.

Methods:
Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham surgery before body weight, body composition, diet preference, and glucose and lipid metabolic endpoints were assessed.

Results:
We found increased duodenal production of OEA and expression of both GPR119 and CD36 were upregulated in wild-type mice after VSG. However, weight loss and glucose tolerance were improved in response to VSG in PPARαKO, GPR119KO, and CD36KO mice. In fact, VSG corrected hepatic triglyceride dysregulation in CD36KO mice, and circulating triglyceride and cholesterol levels in PPARαKO mice. Lastly, we found PPARα-mediated signaling contributes to macronutrient preference independent of VSG, while removal of CD36 signaling blunts the VSG-induced shift toward carbohydrate preference.

Conclusions:
In the search for more effective and less invasive therapies to help reverse the global acceleration of obesity and obesity-related disease OEA is a promising candidate; however, our data indicate that it is not an underlying mechanism of the effectiveness of VSG.
High Calcineurin Inhibitor Intrapatient Variability Is Associated With Renal Allograft Inflammation, Chronicity, and Graft Loss
Authors: Sharma Akhil , Cherukuri Aravind , Mehta Rajil B. , Sood Puneet , Hariharan Sundaram 
Published: February 2019

Background
High calcineurin inhibitor (CNI) intrapatient variability (IPV) has been associated with poor kidney allograft outcomes. However, the relationship between early allograft histological changes, their progression, and CNI-IPV is less well studied. Hence, we evaluated effect of CNI-IPV defined by the degree of fluctuation of CNI levels in all kidney transplant patients over 2 to 12 months posttransplant on early allograft inflammation, subsequent chronicity, and later clinical outcomes.

Methods
Two hundred eighty-six patients transplanted from January 2013 to November 2014 were enrolled with protocol and indication biopsies. The mean CNI-IPV was 28.5% and a quarter of our cohort had IPV of 35% or greater (high CNI IPV). Baseline demographic differences were similar between high and low CNI IPV groups.

Results
High CNI-IPV was associated with a higher incidence of acute rejection (AR) within 1 year (52% vs 31% P < 0.001), more persistent/recurrent AR by 1 year (18.2% vs 6.2%, P = 0.002), higher-grade AR (≥Banff 1B, 27.5% vs 7.3%, P < 0.001), and worse interstitial fibrosis/tubular atrophy (P = 0.005). High CNI-IPV was associated with increased graft loss (GL) and impending graft loss (iGL, defined as eGFR<30 ml/min and >30% decline in eGFR from baseline), regardless of donor-specific antibody, delayed graft function, rejection, or race. In a multivariate Cox Proportional Hazards Model, high CNI-IPV was independently associated with GL + iGL (hazard ratio, 3.1; 95% confidence interval, 1.6–5.9, P < 0.001).

Conclusions
High CNI-IPV within 1 year posttransplant is associated with higher incidence of AR, severe AR, allograft chronicity, GL, and iGL. This represents a subset of patients who are at risk for poor kidney transplant outcomes and potentially a modifiable risk factor for late allograft loss.
Reconstruction of a Pancreatic Allograft With Variant Arterial Anatomy for Transplantation
Authors: Adamson Dylan , Holzner Matthew L. , Wadhera Vikram , Shapiro Ron 
Published: February 2019

Abstract
Donor pancreas utilization rates remain low and aberrant donor anatomy can lead to organ discard by transplant centers. We report on a case of successful pancreas transplantation using a graft with variant arterial anatomy demonstrating that arterial reconstruction is a viable option if aberrant anatomy is encountered at the donor operation. Efforts must be made to use all pancreas grafts that are felt to be of appropriate quality.