bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of single-layered continuous and interrupted gastrointestinal anastomosis in pediatric patients
Authors: Liu Qianyang , Li Ping , Guo Chunbao 
Published: September 2019

Abstract
Background Optimal gastrointestinal construction in pediatric patients still exist controversy as to the technique for the anastomosis. The study was to investigate the advantage of single-layered continuous anastomosis for pediatric patients who underwent intestinal anastomosis on emergency or electively laparotomy. Methods The medical records of 252 patients with single-layered continuous anastomosis and 196 patients with two-layered interrupted anastomosis, served as control, were reviewed retrospectively. Clinical outcomes, including postoperative complications, overall expenditure, postoperative hospital stay and anastomotic leakage, were compared according to the single-layered or two-layered anastomosis. Results Single-layered continuous anastomosis was associated with advantageous postoperative outcomes, including anastomotic time (p<0.001), operative time (p=0.041) and overall expenditure (p=0.009). A reduction trend for postoperative hospital stay was indicated in patients receiving single-layer anastomoses (p= 0.09). There was also an decreased of inflammation variables, C-reactive protein [CRP]) at postoperative days (POD) 5 ( p = 0.032) in the single-layer anastomoses patients. There were no differences for the other main complications. Conclusions Beneficial effects of single-layered continuous anastomosis in terms of anastomotic time, faster postoperative recovery and cost incurred in pediatric patients were demonstrated.
A study of the dose-response relationship for transscleral cyclophotocoagulation in refractory glaucoma
Authors: Xu Yao , Shen Wei 
Published: September 2019

Abstract
Background To research the efficiency of transscleral cyclophotocoagulation (TCP) in refractory glaucoma and to evaluate the dose-response relationship. Methods A retrospective analysis of the cases of 31 eyes of 31 consecutive patients with uncontrolled glaucoma who underwent TCP. Six to thirty-six months were reviewed. The main outcome measure is intraocular pressure (IOP) reduction combined with the best corrected visual acuity and complications. Calculations were performed to determine possible predictive factors that would help establish optimal treatment parameters. Results All the 31 patients felt a relieved ocular pain after TCP. Corneas of 30 eyes recovered transparent one week after TCP, except one eye with corneal epithelialization. The IOP of all patients decreased to 5mmHg-38mmHg（average is 17.93±8.00mmHg）at the end of follow-up. The main earlier complications include conjunctival burns, hyphema and mild inflammation of the anterior chamber, and the late complications were phthisis bulbi and corneal staphyloma. Final IOP was moderately negative related to the number of spots, r=-0.41(t=2.05, P<0.05), and the linear regression equation is y=27.53-0.62x (independent variable x represents the number of spots, dependent variable y represents the final IOP). To a medium extent, the final IOP was negatively correlated with the number of the audible spots, r=-0.58(t=3.75, P<0.01), and the linear regression equation is y=28.39-1.26x. Conclusion Cyclophotocoagulation is a convenient, safe and effective procedure in refractory glaucoma. The recommended parameter is about 14 spots or 8 audible spots.
Assessment of inventory and store management practices of pharmaceuticals in public health centers and hospitals of Dessie Town, Ethiopia
Authors: Bayked Ewunetie Mekashaw , Kahissay Mesfin Haile , Workneh Birhanu Demeke 
Published: September 2019

Abstract
Background: Inventory management is the safe practice of proper storage, distribution of items and accurate record keeping. It is the pumping organ of the drug supply system without which the whole health care service will collapse. The purpose of this study was so to assess inventory and store management practices of pharmaceuticals in public health centers and hospitals of Dessie Town, Ethiopia.
Method: The study was conducted from February 5 to 24, 2019. The study design was institution based cross sectional study. Data were collected by observation check lists. 10 health institutions (2 hospitals and 8 health centers) were studied.
Result: Receipts, issues, losses and adjustments were correctly recorded in 7 stores but with calculation fallacies. Invoices and bin cards were available in all stores. Logistic management and information system, Internal Facility Report and Resupply, and Report and Requisition Form were available in 9 stores. 5 stores had stock cards but only 3 recorded prices correctly on it. The maximum, minimum, re-order and buffer stocks levels were not properly maintained and automated in all stores. All stores had freezers but wall thermometers and lockable cabinets were absent in 8 stores; most (n = 7) did not use First Expired, First out storage technique. Humidity and fire control mechanisms were absent in all and seven institutions respectively; however, 9 institutions lack fire proof areas for combustibles but 8 stores held them with drugs.
Conclusion: The inventory and store management practices of the institutions were not satisfactory. The major problems in these institutions were calculation and recording errors; stock maintenance problem; lack of automation in recording; absence of wall thermometers, humidity and fire control systems and lockable cabinets; fail to use First Expired, First out storage technique and holding combustibles with drugs.
Novel biomarker of Cysteine-rich angiogenic inducer 61 (Cyr61) predicts long-term outcome of ST-elevation myocardial infarction
Authors: Xiang Rui , Mao Min , Tang Ping , Gu Jun , Ma Kanghua 
Published: September 2019

Abstract
Background: Cysteine-rich angiogenic inducer 61 (Cyr61) is a matricellular protein participating in the angiogenesis, inflammation, and fibrotic tissue repair. Previous study has proven its value in diagnosing and risk stratification of ST-elevation myocardial infarction (STEMI). However, there is no study focusing on Cyr61 and the long-term outcome of STEMI.
Methods: A total of 426 patients diagnosed with STEMI were enrolled in this study. Blood sample was acquired 24 hours after the admission. The patients were required long-term follow-up after the discharge, when primary endpoint of all-cause death and secondary endpoint of cardiac complications were observed. Cox hazard ratio model and survival analysis were used to compare the risk of patients with higher level and lower level of Cyr61.
Results: We conducted an average of (48.4 ± 17.8) months of follow-up, during which a total of 28 deaths happened (6.6%), while 106 episodes of secondary endpoints occurred (24.9%). Patients with higher quartile (Q4) Cyr61 were at higher risk of death [HR 3.404 95%CI (1.574-7.360), P<0.001] when compared with lower three quartiles (Q1-Q3) Cyr61. In terms of secondary endpoints, patients with Q4 Cyr61 were subject to 4.718 [95%CI (3.189-6.978) , P<0.001] times of risk compared with Q1-Q3 Cyr61.
Conclusions: For STEMI Patients, those with increased Cyr61 have higher risk of all-cause death and cardiac complications. Therefore, Cyr61 may be a useful tool in predicting the long-term prognosis of STEMI.
The rs13129697 polymorphism of the SLC2A9 gene, but not rs7442295 is associated with impaired glucose tolerance/impaired fasting glucose complicated with hyperuricaemia in Han Chinese males
Authors: Yuan Ying , Chen Tao , Lv Qiu-lan , Zhang Ning , Cui Xue-Na , Zhou Guo-Fang , Yi Xuan-Long , Xing Shichao 
Published: September 2019

Abstract
Aims SLC2A9 is also known as glucose transporter9 (GLUT9) or urate efflux transporter (URAT)v1, which should be involved in the transport of glucose and uric acid. To further verify it, the correlation of the SLC2A9 polymorphisms(rs13129697,rs7442295) with T2DM, Hyperuricemia (HUA) and T2DM compared with HUA will be investigated in male Han Chinese. Methods Two SNPs of the SLC2A9, rs13129697, rs7442295, were genotyped in 285 T2DM patients, 300 HUA patients and 198 T2DM compared with HUA patients respectively through TaqMan-MGB Duplex real-time PCR, and 550 healthy subjects were selected as control group. The total 1333 subjects were all recruited from the Affiliated Hospital of Qingdao University Medical School. Results Compared with control group, the variant SNP of rs13129697 was both significantly associated with HUA group(P<0.001) and T2DM complicated HUA group(P<0.05), but not with pure T2DM group. After adjustment for age, triglyceride and cholesterol, logistic regression analysis showed that people with GT、GG genotype had lower risks of HUA(OR=0.615,95%CI: 0.432-0.877,P=0.007;OR=0.447, 95%CI:0.271-0.736, P=0.002)and T2DM complicated HUA(OR=0.578,95%CI: 0.360-0.923, P=0.022;OR=0.393,95%CI: 0.208-0.740,P= 0.004) than people with TTgenotype. However, there were no statistical significance between control group and T2DM group, HUA group, or T2DM complicated with HUA group in rs7442295 genotypes(P>0.05). Conclusion The rs13129697 polymorphism of the SLC2A9 gene, but not rs7442295 is associated with impaired glucose tolerance/impaired fasting glucose complicated with hyperuricaemia. And G allele may protect against the risk to develop HUA.
Evaluating the national multisite implementation of dialectical behaviour therapy in a community setting: A mixed methods approach
Authors: Flynn Daniel , Joyce Mary , Gillespie Conall , Kells Mary , Swales Michaela , Spillane Ailbhe , Hurley Justina , Hayes Aoife , Gallagher Edel , Arensman Ella , Weihrauch Mareike 
Published: September 2019

Abstract
Background The implementation of evidence-based interventions for borderline personality disorder in community settings is important given that individuals with this diagnosis are often extensive users of both inpatient and outpatient mental health services. Although work in this area is limited, previous studies have identified facilitators and barriers to successful DBT implementation. This study seeks to expand on previous work by evaluating a coordinated implementation of DBT in community settings at a national level. The Consolidated Framework for Implementation Research (CFIR) [1] provided structural guidance for this national level coordinated implementation.Methods A mixed methods approach was utilised to explore the national multi-site implementation of DBT from the perspective of team leaders and therapists who participated in the coordinated training and subsequent implementation of DBT. Qualitative interviews with DBT team leaders (n = 8) explored their experiences of implementing DBT in their local service and was analysed using content analysis. Quantitative surveys from DBT therapists (n = 74) examined their experience of multiple aspects of the implementation process including orienting the system, and preparations and support for implementation. Frequencies of responses were calculated. Written qualitative feedback was analysed using content analysis.Results Five themes were identified from the interview data: team formation, implementation preparation, client selection, service level challenges and team leader role. Participants identified team size and support for the team leader as key points for consideration in DBT implementation. Key challenges encountered were the lack of system support to facilitate phone coaching and a lack of allocated time to focus on DBT. Implementation facilitators included having dedicated team members and support from management.Conclusions The barriers and facilitators identified in this study are broadly similar to those reported in previous research. Barriers and facilitators were identified across several domains of the CFIR and are consistent with a recently published DBT implementation Framework [2]. Future research should pay particular attention to the domain of characteristics of individuals involved in DBT implementation. The results highlight the importance of a mandated service plan for the coordinated implementation of an evidence-based treatment in a public health service.Trial Registration: ClinicalTrials.gov ID: NCT03180541; Registered June 7th 2017 ‘retrospectively registered’
Health Insurance Benefit Package in Iran: A Qualitative Policy Process Analysis
Authors: Mohamadi Efat , Olyaeemanesh Alireza , Takian Amirhossein , Rashidian Arash , Hassanzadeh Ali , Razavi Moaven , Ghazanfari Sadegh 
Published: September 2019

Abstract
Introduction The lack of transparency in prioritization of health services, multiple health insurance organizations with various and not-aligned policies, plus limited resources to provide comprehensive health coverage are among the challenges to design appropriate Health Insurance benefit Package (HIBP) in Iran.Method data collection was done through semi-structured interviews with 25 experts, plus document analysis and observation, from February 2014 until October 2016. Using both deductive and inductive approaches, two independent researchers analyzed data and used MAXQDA.11 software for data management.Results We identified 10 main themes, plus 81 sub-themes related to development and implementation of BP, including: lack of transparent criteria for inclusion of services within BP, inadequate use of scientific evidences in determination of BP, lack of evaluation systems, and weak decision-making process. We propose 11 solutions and 25 policy options to improve the situation.Discussion Design and implementation of HIBP did not follow evidence-based and logical algorithm in Iran. Rather, political and financial influences at the macro level determined the decisions. This is rooted in social, cultural and economic norms in the country, whereby political and economic factors have the greatest impact on the implementation of HIBP.Conclusion To define a cost-effective HIBP in Iran, it is pivotal to develop transparent and evidence-based guidelines about the processes and the stewardship of BP, which are in line with upstream policies and societal characteristics. Worse still, the possible conflict of interests and its harms need to be minimized in advance.
Post-Traumatic Stress Disorder in Italy: a comprehensive evaluation of all the ICD comorbidities and gender-related differences
Authors: Ferretti Fabio , Pozza Andrea , Bossini Letizia , Desantis Serena , Olivola Miriam , Matto Laura Del , Gualtieri Giacomo , Gusinu Roberto , Bezzini Daiana , Fagiolini Andrea , Coluccia Anna 
Published: September 2019

Abstract
Objectives: The association between Post-Traumatic Stress Disorder (PTSD) and medical comorbidities is controversial since most studies focused on specific comorbidity and victim types. In Italy, data on this issue are scarce. A comprehensive evaluation of all the ICD medical categories co-occurring in PTSD may orient assessment and treatment during clinical and forensic practice. This is the first study evaluating all the ICD physical comorbidities and gender-related differences in Italian PTSD patients. Eighty-four PTSD patients (36 females, 48 males) were included. The Clinician-Administered PTSD Scale, Mini International Neuropsychiatric Interview and Davidson Trauma Scale were administered. Results: Most patients had a PTSD consequent to an accident and half of them presented extreme symptom severity. No gender differences emerged on symptom severity/duration and age at the event. Metabolic (39.29%), circulatory (20.24%) and musculoskeletal systems/connective tissue diseases (17.86%) were the most frequent comorbidities. Metabolic/circulatory diseases were more frequent among males (p=0.019 and p= 0.027, respectively) while females more frequently showed neoplasms (p=0.039). Physical comorbidities represent a serious complication in PTSD patients and are more prevalent than in the Italian population. While gender is not associated with symptom presentation, it seems to play a key role in specific comorbidities including metabolic, circulatory and neoplastic diseases.
Association Between Water, Sanitation, General Hygiene And Oral Hygiene Practices Of Street-Involved Young People In Southwest Nigeria
Authors: Folayan Morenike Oluwatoyin , Obiyan Mary O. , Olaleye Atinuke O. 
Published: September 2019

Abstract
Background Oral hygiene practices can be linked to personal hygiene practices, including access to water and other sanitation facilities. The objective of the study was to determine if there is an association between oral hygiene practices and water and sanitation hygiene (WASH) practices among street-involved young people (SIYP).Methods A cross-sectional study involving SIYP age 10-24 years in two states in Nigeria recruited through respondent-driven sampling was conducted. Interviewer-administered questionnaires were used to collect data on water access, sanitation personal and oral hygiene. The instruments used for collecting the data were standardized tools for measuring the phenomena studied. The association between knowledge and practice of oral hygiene; oral hygiene and water, sanitation and hygiene (WASH), and indicators of good oral hygiene were assessed.Results We found that the proportion of SIYP with good knowledge of oral hygiene was high (84.9%), but fewer had good oral hygiene practice (8.9%). There were significant associations between knowledge and practice of tooth cleaning, use of fluoride-containing toothpaste, dental flossing, consumption of sugar between meals, and frequency of dental check-ups (p<0.001 respectively). Respondents with good water collection and storage (AOR: 2.40; 95% CI: 1.31-4.38; P=0.004) and those residing in Lagos (AOR: 2.61; 95% CI: 1.42-4.80; P=0.002) had higher likelihood of having good oral hygiene.Conclusion Good oral hygiene practices of SIYP in Nigeria is associated with access to water collection and storage. WASH programs can have impact on health through improved oral hygiene practices.
Phosphorus Management in High‐Yield Systems
Authors: Hopkins Bryan G. , Hansen Neil C. 
Published: September 2019

The discovery and development of phosphorus (P) and P fertilizers provide context for current management conventions. Average crop yields were stagnant before the Green Revolution but have steadily increased since. This, along with conventional P management, has resulted in widely depleting soil P levels. Improved technology and management are needed to meet the increasing P demand. Modern hybrids and cultivars have different P demand and uptake patterns that require changes in conventional P fertilizer placement and timing. Phosphorus fertilizer recommendations based on soil analysis remains valid, but evidence suggests a need for recalibrating soil test P (STP) critical levels (the STP concentration at which a response to P fertilizer would not be expected) and P fertilizer rates to accommodate high‐yield scenarios. Considering higher P fertilizer rates as a single solution poses environmental challenges, highlighting the need for improved P use efficiency (PUE). Phosphorus fertilization approaches that have the potential to improve PUE and enable high yields include crop‐specific precision placement of P, informed timing of P fertilizers, and new enhanced efficiency sources of P fertilizer. This paper examines these management approaches from historical, production, and environmental perspectives in modern cropping systems.Core Ideas
History of P fertilization illuminates traditional soil P management and needed changes.
Recalibration of STP and P fertilizer recommendations are needed to match increasing yield and rates of P uptake.
Environmental concerns and diminishing P supply necessitate improvement in P use efficiency.
Placement and timing are improved through understanding of variable rooting patterns.
Enhanced efficiency P fertilizers can be effective if applied correctly.
Analysis of Escherichia coli and Enterococci Concentrations Patterns in a Pennsylvania Creek Using Empirical Orthogonal Functions
Authors: Jeon Dong Jin , Pachepsky Yakov , Harriger Dana , Picard Rachael , Coppock Cary , Wells Edward , Hong Eun‐Mi 
Published: September 2019

Assessing microbial quality of irrigation water is important to prevent foodborne illnesses caused by fresh produce contamination. Generic Escherichia coli and enterococci are commonly used to evaluate the microbial water quality. The objective of this study was to see if patterns in spatial distributions of the fecal indicator bacteria concentrations along a creek at baseflow that are preserved over time can be detected. Such patterns are commonly referred to as temporally stable patterns. Microbial concentrations were measured along the Conococheague Creek in Pennsylvania during 3 yr on weeks when the creek was at base flow. The upstream sampling location was at the outlet of the forested subwatershed, next two locations were in agricultural area dominated by crops and pastures, and another two were in urbanized areas. Empirical orthogonal functions (EOFs) have been applied to detect a temporally stable spatial pattern. The most significant spatial pattern of both bacteria was followed the change of land use; 74.6 and 68.6% were explained by the first EOF for E. coli and enterococci, respectively. Much less variability (19.6 and 17%) was explained by impacts of tributary and braided sections of the creek. A good approximation of the average logarithms of concentrations across the studied reach was provided by logarithms of concentrations at the sampling location where the first EOF was close to zero. We confirmed that EOF analysis can uncover the significant multiple temporally stable spatial patterns for the fecal indicator bacteria concentration along the creek in the presence of multiple land uses.Core Ideas
The first spatial pattern of fecal indicator bacteria (FIB) reflected land use.
Much less variability was explained by tributary and braided sections of the creek.
The highest concentrations of FIB were observed in the urbanized area.
The FIB concentrations were relatively lower in the agricultural area.
Brassica carinata and Brassica napus Growth, Nitrogen Use, Seed, and Oil Productivity Constrained by Post‐Bolting Nitrogen Deficiency
Authors: Seepaul Ramdeo , Small Ian M. , Marois Jim , George Sheeja , Wright David L. 
Published: September 2019

ABSTRACTNitrogen limitation after bolting in oilseed brassicas limits reproductive performance as nutrients are sequentially translocated from leaves to developing reproductive structures. In addition to limiting crop growth and productivity, N deficiency may also modify the chemical composition and oil output of Brassica carinata A. Braun and B. napus L. A greenhouse study was conducted at the North Florida Research and Education Center in Quincy, FL, during 2014–2015 to determine the effects of N limitation on B. carinata (cultivar AAC A110) and B. napus (cultivar Canterra 1918) growth, seed and oil yields, N use, and fatty acid composition. Four N treatments (0, 33, 66, and 100% of N in full strength Hoagland solution) were imposed 78 d after planting (DAP) at bolting. At 154 DAP, carinata accumulated 19% greater biomass and nine times more reproductive branches than napus across all N levels. As a result, carinata produced 43% greater seed yield across all N levels than napus. This increased seed productivity resulted in greater agronomic efficiency (58%), apparent N recovery (59%), N utilization efficiency (41%), and partial factor productivity (29%) than napus, respectively. Restricting N availability (0 N) reduced carinata and napus oil yield by 35 and 50% respectively, relative to 100% N. Nitrogen availability during seed development and maturation had an effect on the synthesis of fatty acids and their quantities in the oils of mature carinata and napus seeds. This study demonstrated the plasticity of oilseed brassicas and the relationship of reduced growth to seed productivity as a function of N supply.