bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II
Authors: Pi Min , Ye Ruisong , Han Xiaobin , Armstrong Benjamin , Liu Xue , Chen Yuanjian , Sun Yao , Quarles L. Darryl 
Published: August 2018

AbstractBoth the activation of the renin angiotensin aldosterone system (RAAS) and elevations of circulating Fibroblast Growth Factor-23 (FGF-23) have been implicated in the pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease. To investigate potential cross-talk between RAAS and FGF-23, we administered angiotensin II (Ang II) to wild-type rodents and the Hyp mouse model of excess FGF-23. Ang II administration for four weeks to wild-type rodents resulted in significant increases in systolic blood pressure and LVH. Unexpectedly, FGF-23 circulating levels were increased by 1.5–1.7 fold in Ang II treated animals. In addition, Ang II treatment increased expression of FGF-23 message levels in bone, the predominant tissue for FGF-23 production, and induced expression of FGF-23 and its co-receptor α-Klotho in the heart, which normally does not express FGF-23 or α-Klotho in physiologically relevant levels. Hyp mice with elevated FGF-23 exhibited increased blood pressure and LVH at baseline. Ang II administration to Hyp mice resulted further increments in blood pressure and left ventricular hypertrophy, consistent with additive cardiovascular effects. These findings suggest that FGF-23 may participate in unexpected systemic and paracrine networks regulating hemodynamic and myocardial responses.
Automatic hyoid bone detection in fluoroscopic images using deep learning
Authors: Zhang Zhenwei , Coyle James L. , Sejdić Ervin 
Published: August 2018

AbstractThe displacement of the hyoid bone is one of the key components evaluated in the swallow study, as its motion during swallowing is related to overall swallowing integrity. In daily research settings, experts visually detect the hyoid bone in the video frames and manually plot hyoid bone position frame by frame. This study aims to develop an automatic method to localize the location of the hyoid bone in the video sequence. To automatically detect the location of the hyoid bone in a frame, we proposed a single shot multibox detector, a deep convolutional neural network, which is employed to detect and classify the location of the hyoid bone. We also evaluated the performance of two other state-of-art detection methods for comparison. The experimental results clearly showed that the single shot multibox detector can detect the hyoid bone with an average precision of 89.14% and outperform other auto-detection algorithms. We conclude that this automatic hyoid bone tracking system is accurate enough to be widely applied as a pre-processing step for image processing in dysphagia research, as well as a promising development that may be useful in the diagnosis of dysphagia.
Linear and Volumetric Mandibular Asymmetries in Adult Patients With Different Skeletal Classes and Vertical Patterns: A Cone-Beam Computed Tomography Study
Authors: Mendoza Luz Victoria , Bellot-Arcís Carlos , Montiel-Company José María , García-Sanz Verónica , Almerich-Silla José Manuel , Paredes-Gallardo Vanessa 
Published: August 2018

AbstractThis study aimed to quantify the height of the mandibular condyle and ramus, condylar volume, and the asymmetry index in adult patients of different sex, skeletal class and vertical pattern using Cone-Beam Computed Tomography (CBCT), and to determine whether there were differences between these groups. The study used CBCT scans of 159 patients with a mean age of 32.32 ± 8.31 years. InVivoDental® software was used to perform both linear (condylar, ramal, and total height) and condylar volume measurements. Linear and volumetric asymmetries were calculated. There were not significant differences between right and left sides. The mean value obtained for condyle height was 7.27 mm, ramus height 42.3 mm, total height 49.6 mm and condyle volume 1907.1 mm3, with significant differences between men and women. Significantly higher values were found for condylar volume in hypodivergent patterns (p = 0.001) and for the asymmetry index of the condylar volume in Class II patients (p < 0.05). The prevalence of relevant asymmetry was high for condyle height and volume (73.1% y 75.6% respectively). Higher height and volume values were found among men, Class III, and hypodivergent patients. Linear and volumetric asymmetries were more prevalent among men, Class III and hyperdivergent patterns.
Synthesis of biogenic silver nanoparticles using Althaea officinalis as reducing agent: evaluation of toxicity and ecotoxicity
Authors: Rheder Diogo Torres , Guilger Mariana , Bilesky-José Natália , Germano-Costa Taís , Pasquoto-Stigliani Tatiane , Gallep Tatiane Balbo Batista , Grillo Renato , Carvalho Cleoni dos Santos , Fraceto Leonardo Fernandes , Lima Renata 
Published: August 2018

AbstractSilver nanoparticles (AgNPs) are known mainly because of their bactericidal properties. Among the different types of synthesis, there is the biogenic synthesis, which allows the synergy between the nanocomposites and substances from the organism employed for the synthesis. This study describes the synthesis of AgNPs using infusion of roots (AgNpR) and extract (AgNpE) of the plant Althaea officinalis. After the synthesis through reduction of silver nitrate with compounds of A. officinalis, physico-chemical analyzes were performed by UV-Vis spectroscopy, nanoparticles tracking analysis (NTA), dynamic light scattering (DLS) and scanning electron microscopy (SEM). Toxicity was evaluated through Allium cepa assay, comet test with cell lines, cell viability by mitochondrial activity and image cytometry and minimal inhibitory concentration on pathogenic microorganisms. Biochemical analyzes (CAT - catalase, GPx - glutathione peroxidase e GST - glutationa S-transferase) and genotoxicity evaluation in vivo on Zebrafish were also performed. AgNpE and AgNpR showed size of 157 ± 11 nm and 293 ± 12 nm, polydispersity of 0.47 ± 0.08 and 0.25 ± 0.01, and zeta potential of 20.4 ± 1.4 and 26.5 ± 1.2 mV, respectively. With regard to toxicity, the AgNpE were the most toxic when compared with AgNpR. Biochemical analyzes on fish showed increase of CAT activity in most of the organs, whereas GPx showed few changes and the activity of GST decreased. Also regarding to bactericidal activity, both nanoparticles were effective, however AgNpR showed greater activity. Althaea officinalis can be employed as reducing agent for the synthesis of silver nanoparticles, although it is necessary to consider its potential toxicity and ecotoxicity.
Gravity measurements below 10−9 g with a transportable absolute quantum gravimeter
Authors: Ménoret Vincent , Vermeulen Pierre , Le Moigne Nicolas , Bonvalot Sylvain , Bouyer Philippe , Landragin Arnaud , Desruelle Bruno 
Published: August 2018

AbstractGravimetry is a well-established technique for the determination of sub-surface mass distribution needed in several fields of geoscience, and various types of gravimeters have been developed over the last 50 years. Among them, quantum gravimeters based on atom interferometry have shown top-level performance in terms of sensitivity, long-term stability and accuracy. Nevertheless, they have remained confined to laboratories due to their complex operation and high sensitivity to the external environment. Here we report on a novel, transportable, quantum gravimeter that can be operated under real world conditions by non-specialists, and measure the absolute gravitational acceleration continuously with a long-term stability below 10 nm.s−2 (1 μGal). It features several technological innovations that allow for high-precision gravity measurements, while keeping the instrument light and small enough for field measurements. The instrument was characterized in detail and its stability was evaluated during a month-long measurement campaign.
Net-Net Auto Machine Learning (AutoML) Prediction of Complex Ecosystems
Authors: Barreiro Enrique , Munteanu Cristian R. , Cruz-Monteagudo Maykel , Pazos Alejandro , González-Díaz Humbert 
Published: August 2018

AbstractBiological Ecosystem Networks (BENs) are webs of biological species (nodes) establishing trophic relationships (links). Experimental confirmation of all possible links is difficult and generates a huge volume of information. Consequently, computational prediction becomes an important goal. Artificial Neural Networks (ANNs) are Machine Learning (ML) algorithms that may be used to predict BENs, using as input Shannon entropy information measures (Shk) of known ecosystems to train them. However, it is difficult to select a priori which ANN topology will have a higher accuracy. Interestingly, Auto Machine Learning (AutoML) methods focus on the automatic selection of the more efficient ML algorithms for specific problems. In this work, a preliminary study of a new approach to AutoML selection of ANNs is proposed for the prediction of BENs. We call it the Net-Net AutoML approach, because it uses for the first time Shk values of both networks involving BENs (networks to be predicted) and ANN topologies (networks to be tested). Twelve types of classifiers have been tested for the Net-Net model including linear, Bayesian, trees-based methods, multilayer perceptrons and deep neuronal networks. The best Net-Net AutoML model for 338,050 outputs of 10 ANN topologies for links of 69 BENs was obtained with a deep fully connected neuronal network, characterized by a test accuracy of 0.866 and a test AUROC of 0.935. This work paves the way for the application of Net-Net AutoML to other systems or ML algorithms.
Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: objective, longitudinal assessment of skin color
Authors: Yamazaki Hideya , Takenaka Tadashi , Aibe Norihiro , Suzuki Gen , Yoshida Ken , Nakamura Satoaki , Masui Koji , Kimoto Takuya , Sasaki Naomi , Nishimura Tsuyoshi , Nakashima Akihiro , Goto Mariko , Yamada Kei 
Published: August 2018

AbstractThis study aimed to quantitatively compare radiation dermatitis due to hypofractionated (Hypo) and conventionally fractionated (Conv) external-beam radiotherapy in patients who underwent postoperative radiotherapy after breast-conserving surgery. Skin color changes, in terms of L* (brightness, white-black), a* (red-green), and b* (yellow-blue) values, due to external-beam radiotherapy were examined at alternate fractions using an objective method. Twenty-six patients were included in the Hypo group (42.56 Gy/16 fractions) and 46 in the Conv group (50 Gy/25 fractions). Radiotherapy decreased the L* value (darker) and increased the a* value (redder) gradually. These color alterations progressed linearly according to elapsed fractions and were similar between Hypo and Conv per fraction. The Hypo group showed significantly milder alterations in L* and a* values than the Conv group. The maximal dosage was significantly correlated to alterations in L* and a* values. Common Terminology Criteria for Adverse Events v4 assessment did not show a statistically significant difference between the Hypo (Grade 0:1:2 = 2:24:1) and Conv (1:39:6, p = 0.25) groups. The results of our objective analysis revealed that patients undergoing Hypo show milder color alteration than those undergoing Conv and that the maximal dosage is a useful predicator of color alteration.
Development of an oxidative stress in vitro assay in zebrafish (Danio rerio) cell lines
Authors: Lungu-Mitea Sebastian , Oskarsson Agneta , Lundqvist Johan 
Published: August 2018

AbstractThe nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular defense against oxidative stress and correlated with classical toxicological endpoints. In vitro methods using fish cell lines for the assessment of aquatic toxicity are needed for mechanistic studies and as an alternative to in vivo. We describe an in vitro assay to study oxidative stress using zebrafish cell lines. Transfection efficiency of twelve commercially available transfection reagents were tested in the zebrafish cell lines ZFL, ZF4, and Pac2. The most efficient reagent for each cell line was selected for further experiments. Cells were transiently transfected with an Nrf2-responsive luciferase plasmid. The assay was tested using the oxidative stress inducing chemicals tertbutylhydroquinone, hydrogen peroxide, and sulforaphane. Of the transfected cell lines, ZF4 and ZFL showed higher sensitivity. The latter were used to study potential oxidative stress induced by pesticides (diazinon, deltamethrin, atrazine, metazachlor, terbutylazine, diuron). Besides known inducers, Nrf2 activity was also significantly induced by diazinon, deltametrin, diuron, and metazachlor. Activation of Nrf2 by metazachlor is a novel finding. The described assay could be a valuable tool for research in toxicology to study the stress response of both pure chemicals and environmental water samples.
Atomic number dependence of Z contrast in scanning transmission electron microscopy
Authors: Yamashita Shunsuke , Kikkawa Jun , Yanagisawa Keiichi , Nagai Takuro , Ishizuka Kazuo , Kimoto Koji 
Published: August 2018

AbstractAnnular dark-field (ADF) imaging by scanning transmission electron microscopy (STEM) is a common technique for material characterization with high spatial resolution. It has been reported that ADF signal is proportional to the nth power of the atomic number Z, i.e., the Z contrast in textbooks and papers. Here we first demonstrate the deviation from the power-law model by quantitative experiments of a few 2D materials (graphene, MoS2 and WS2 monolayers). Then we elucidate ADF signal of single atoms using simulations to clarify the cause of the deviation. Two major causes of the deviation from the power-law model will be pointed out. The present study provides a practical guideline for the usage of the conventional power-law model for ADF imaging.
Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration
Authors: Tomita Kyoko , Sakurai Fuminori , Iizuka Shunsuke , Hemmi Masahisa , Wakabayashi Keisaku , Machitani Mitsuhiro , Tachibana Masashi , Katayama Kazufumi , Kamada Haruhiko , Mizuguchi Hiroyuki 
Published: August 2018

AbstractPre-existing anti-adenovirus (Ad) neutralizing antibodies (AdNAbs) are a major barrier in clinical gene therapy using Ad vectors and oncolytic Ads; however, it has not been fully elucidated which Ad capsid protein-specific antibodies are involved in AdNAb-mediated inhibition of Ad infection in vivo. In this study, mice possessing antibodies specific for each Ad capsid protein were prepared by intramuscular electroporation of each Ad capsid protein-expressing plasmid. Ad vector-mediated hepatic transduction was efficiently inhibited by more than 100-fold in mice immunized with a fiber protein-expressing plasmid or a penton base-expressing plasmid. An Ad vector pre-coated with FX before administration mediated more than 100-fold lower transduction efficiencies in the liver of warfarinized mice immunized with a fiber protein-expressing plasmid or a penton base-expressing plasmid, compared with those in the liver of warfarinized non-immunized mice. These data suggest that anti-fiber protein and anti-penton base antibodies bind to an Ad vector even though FX has already bound to the hexon, and inhibit Ad vector-mediated transduction. This study provides important clues for the development of a novel Ad vector that can circumvent inhibition with AdNAbs.
High-field nonlinear optical response and phase control in a dielectric laser accelerator
Authors: Cesar D. , Custodio S. , Maxson J. , Musumeci P. , Shen X. , Threlkeld E. , England R. J. , Hanuka A. , Makasyuk I. V. , Peralta E. A. , Wootton K. P. , Wu Z. 
Published: August 2018

AbstractAdvances in ultrafast laser technology and nanofabrication have enabled a new class of particle accelerator based upon miniaturized laser-driven photonic structures. However, developing a useful accelerator based on this approach requires control of the particle dynamics at field intensities approaching the damage limit. We measure acceleration in a fused silica dielectric laser accelerator driven by fields of up to 9 GV m−1 and observe a record 1.8 GV m−1 in the accelerating mode. At these intensities the dielectric is driven beyond its linear response and self-phase modulation changes the phase velocity of the accelerating mode, reducing the average gradient to 850 MeV m−1. We show that free-space optics can be used to compensate this dephasing and demonstrate that tailoring the laser phase and amplitude can facilitate optimization of the beam dynamics. This could enable MeV scale energy gain in a single stage and pave the way towards applications in scientific, industrial, and medical fields.
New Approach for B-Mode Ultrasound (US) Evaluation of the Plantar Aponeurosis (PA) Thickness in Healthy Subjects
Authors: Abd Ellah Mohamed , Kremser Christian , Strobl Sylvia , Rauch Stefan , Deml Christian , Kronreif Christian , Klauser Andrea 
Published: August 2018

Purpose To compare ultrasound (US) measurements in the sagittal and axial plane of the plantar aponeurosis (PA) in healthy subjects.
Materials and Methods PA thickness was measured in 40 healthy subjects (mean age: 34 years) by two radiologists using US in sagittal, axial medial and axial lateral planes. Subjects were classified according to gender (female and male) and age (18 – 35 versus 50 – 75 years). All measurements were compared and the interobserver agreement was calculated.
Results The PA was medially significantly thicker than laterally (mean ± std 3.1 ± 0.7 mm versus 2.5 ± 0.5 mm respectively, P< 0.001). A significant difference was found between males and females (3.3 ± 0.7 mm versus 2.9 ± 0.6 mm medially and 2.7 ± 0.6 mm versus 2.3 ± 0.4 mm laterally, p < 0.05) and between the older and younger age groups (3.8 ± 0.6 mm versus 2.8 ± 0.4 mm medially and 3.1 ± 0.4 mm versus 2.3 ± 0.4 mm laterally, p < 0.001). Good interobserver agreement was detected (0.74).
Conclusion Measurement of central and lateral fascicles of the plantar aponeurosis in both planes (sagittal and axial) is recommended in the daily routine.
Key points
Citation Format
Oleic acid increases uptake and decreases the P-gp-mediated efflux of the veterinary anthelmintic Ivermectin
Authors: Houshaymi Bilal , Nasreddine Nadine , Kedees Mamdouh , Soayfane Zeina 
Published: August 2018

AbstractThe bioavailability of ivermectin is modulated by lipid-based formulations and membrane efflux transporters such as Breast Cancer Resistance Protein and P-glycoprotein (BCRP and P-gp). We have investigated the effect of oleic acid on the uptake of ivermectin in vitro using Caco-2 cells and in vivo in the intestines of wild-type mice. Complex micelles (M) with oleic acid induced a significant increase (e. g. for M3 was 7-fold, p≤0.001) in the uptake of the drug in a time-dependent manner with no involvement of cholesterol in the mechanism. In vivo results showed a significant increase in the concentration of plasma and intestinal mucosa ivermectin (p≤0.01) in mice receiving oleic acid-based drug formulation. We also examined the expression of the drug efflux transporter, BCRP and P-gp in Caco-2 cells and found a significant decrease (p≤0.001) in their level in the presence of 5 mM oleic acid. Treatment of mice with oleic acid-based formulation showed a significant decrease in the activity of P-gp in the intestinal mucosa (p≤0.01). This study highlighted the effect of oleic acid in decreasing the expression and the activity of P-gp-mediated ivermectin efflux and in limiting the drug absorption by increasing its uptake and bioavailability in Caco-2 cells and intestine, respectively.
Archaeogenomic evidence from the southwestern US points to a pre-Hispanic scarlet macaw breeding colony
Authors: George Richard J. , Plog Stephen , Watson Adam S. , Schmidt Kari L. , Culleton Brendan J. , Harper Thomas K. , Gilman Patricia A. , LeBlanc Steven A. , Amato George , Whiteley Peter , Kistler Logan , Kennett Douglas J. 
Published: August 2018

Significance
Archaeogenomic analysis of scarlet macaw bones demonstrates that the genetic diversity of these birds acquired by people in the southwestern United States (SW) between 900 and 1200 CE was exceedingly low. Only one mitochondrial DNA haplogroup (Haplo6) is present of the five historically known haplogroups in the lowland forests of Mexico and Central America. Phylogenetic analyses indicate the ancient macaw lineage in the SW shared genetic affinities with this wild lineage. These data support the hypothesis that a translocated breeding colony of scarlet macaws belonging to only one haplogroup existed some distance north of their endemic range, and SW peoples continuously acquired these birds from this unknown location for nearly 3 centuries, as no evidence currently exists for macaw breeding in SW.
Antibiotic prophylaxis and clinical outcomes among older adults with recurrent urinary tract infection: cohort study
Authors: Ahmed Haroon , Farewell Daniel , Jones Hywel M , Francis Nick A , Paranjothy Shantini , Butler Christopher C 
Published: August 2018

Abstract

Background
clinical guidelines recommend antibiotic prophylaxis for preventing recurrent urinary tract infections (UTIs), but there is little evidence for their effectiveness in older adults.

Methods
this was a retrospective cohort study of health records from 19,696 adults aged ≥65 with recurrent UTIs. We used prescription records to ascertain ≥3 months’ prophylaxis with trimethoprim, cefalexin or nitrofurantoin. We used random effects Cox recurrent event models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of clinical recurrence (primary outcome), acute antibiotic prescribing and hospitalisation.

Results
of 4,043 men and 15,653 women aged ≥65 with recurrent UTIs, 508 men (12.6%) and 2,229 women (14.2%) were prescribed antibiotic prophylaxis. In men, prophylaxis was associated with a reduced risk of clinical recurrence (HR, 0.49; 95% CI, 0.45–0.54), acute antibiotic prescribing (HR, 0.54; 95% CI, 0.51–0.57) and UTI-related hospitalisation (HR, 0.78; 95% CI, 0.64–0.94). In women, prophylaxis was also associated with a reduced risk of clinical recurrence (HR, 0.57; 95% CI, 0.55–0.59) and acute antibiotic prescribing (HR, 0.61; 95% CI, 0.59–0.62), but estimates of the risk of UTI-related hospitalisation were inconsistent between our main analysis (HR, 1.16; 95% CI, 1.05–1.28) and sensitivity analysis (HR, 0.82; 95% CI, 0.72–0.94).

Conclusions
antibiotic prophylaxis was associated with lower rates of UTI recurrence and acute antibiotic prescribing in older adults. To fully understand the benefits and harms of prophylaxis, further research should determine the frequency of antibiotic-related adverse events and the impact on antimicrobial resistance and quality of life.
Who Needs Critical Friends? Independent Advisory Groups in the Age of the Police and Crime Commissioner
Authors: Dixon Bill 
Published: August 2018

Abstract
In the early 2000s, many police forces in England and Wales set up independent advisory groups (IAGs) following an inquiry into the flawed investigation of the murder of a black teenager, Stephen Lawrence, by London's Metropolitan Police. Members of IAGs were to act as critical friends of the police providing independent advice on policies, procedures and practices, thus ensuring that no section of their local community was disadvantaged through a lack of understanding, ignorance or mistaken beliefs. Based on a case study of an IAG in an English police force, this article reviews the operation of IAGs following the radical changes made to police governance by the introduction of directly elected police and crime commissioners (PCCs). Its main argument is that more thought needs to be given to the role of IAGs in this new landscape and urgent steps taken to clarify their relationships with police forces and PCCs.