bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment
Authors: Yan Dayun , Xu Wenjun , Yao Xiaoliang , Lin Li , Sherman Jonathan H. , Keidar Michael 
Published: October 2018

AbstractCold Atmospheric Plasma (CAP) is an ionized gas with a near room temperature. CAP is a controllable source for reactive species, neutral particles, electromagnetic field and UV radiation. CAP showed the promising application in cancer treatment through the demonstration in vitro and in vivo. In this study, we first demonstrate the existence of an activation state on the CAP-treated cancer cells, which drastically decreases the threshold of cell vulnerability to the cytotoxicity of the CAP-originated reactive species such as H2O2 and NO2−. The cytotoxicity of CAP treatment is still dependent on the CAP-originated reactive species. The activation state of cancer cells will not cause noticeable cytotoxicity. This activation is an instantaneous process, started even just 2 s after the CAP treatment begins. The noticeable activation on the cancer cells starts 10–20 s during the CAP treatment. In contrast, the de-sensitization of activation takes 5 hours after the CAP treatment. The CAP-based cell activation explains the mechanism by which direct CAP treatment causes a much stronger cytotoxicity over the cancer cells compared with an indirect CAP treatment do, which is a key to understand what the effect of CAP on cancer cells.
Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda
Authors: Migisha Richard , Dan Nyehangane  , Boum Yap , Page Anne-Laure , Zúñiga-Ripa Amaia , Conde-Álvarez Raquel , Bagenda Fred , Bonnet Maryline 
Published: October 2018

AbstractHuman brucellosis, a chronic disease contracted through contact with animals and consuption of unpasteurized dairy products is underreported in limited-resource countries. This cross-sectional study aimed to determine the prevalence and risk factors of brucellosis among febrile patients attending a community hospital in South western Uganda. A questionnaire that captured socio-demographic, occupational and clinical data was administered. Blood samples were tested for Brucella antibodies using Rose Bengal Plate Test (RBPT) and blood culture with standard aerobic BACTEC bottle was done. Of 235 patients enrolled, prevalence of brucellosis (RBPT or culture confirmed) was 14.9% (95% CI 10.6–20.1) with a culture confrmation in 4.3% of the participants. The factors independently associated with brucellosis were consumption of raw milk (aOR 406.15, 95% CI 47.67–3461.69); history of brucellosis in the family (aOR 9.19, 95% CI 1.98–42.54); and selling hides and skins (aOR 162.56, 95% CI 2.86–9256.31). Hepatomegaly (p < 0.001), splenomegaly (p = 0.018) and low body mass index (p = 0.032) were more common in patients with brucellosis compared to others. Our findings reveal a high prevalence of brucellosis among febrile patients and highlight a need for implementing appropiate tests, public awareness activities and vaccination of animals to control and eliminate the disease.
„Dann können wir endlich zeigen, dass das was bringt“
Authors: Schaller Andrea , Exner Anne-Kathrin , Wild Burkhard , Sauzet Odile 
Published: October 2018

ZusammenfassungDie Prinzipien der evidenzbasierten Medizin werden inzwischen auf nahezu alle Gesundheitsberufe angewandt. Damit stehen Wissenschaftler und Praktiker in der Sport- und Bewegungstherapie nicht nur vor der Herausforderung zielgruppen- und Setting-spezifische Interventionen zu entwickeln, sondern diese auch adäquat zu evaluieren. Trotz zahlreicher Studien ist die externe Evidenz für die Wirksamkeit von Bewegungsförderung allerdings gering. Dies ist neben der oft geringen methodischen Qualität der einzelnen Studien auch auf die großen Herausforderungen bezüglich der klinischen Relevanz von Studienergebnissen zurückzuführen.Der vorliegende Beitrag stellt zunächst das Konzept der evidenzbasierten Gesundheitsversorgung (Evidence-Based Health Care) (EbHC) vor. Davon ausgehend werden wichtige Arbeitsschritte bei der Planung einer Interventionsstudie vorgestellt, wobei insbesondere der Aspekt der Relevanz fokussiert wird.
Undergraduate Curricular Training in Musculoskeletal Ultrasound by Student Teachers: The Impact of Peytonʼs Four-Step Approach
Authors: Gradl-Dietsch Gertraud , Hitpaß Lea , Gueorguiev Boyko , Nebelung Sven , Schrading Simone , Knobe Matthias 
Published: October 2018

Zusammenfassung
Hintergrund Der Ultraschall der Bewegungsorgane findet breite Anwendung in der Diagnostik von Pathologien und in der Intervention. Die frühe Implementierung von Ultraschallkursen in das medizinische Curriculum könnte zu einer besseren medizinischen Versorgung führen. Die Sonografie wird häufig mit der „See one, do one“-Methode angeleitet, obgleich unklar bleibt, ob dies die beste Herangehensweise darstellt. Die vorliegende Arbeit untersucht, ob die 4-Schritt-Methode nach Peyton konventionellen Lehrstrategien in der Vermittlung des muskuloskelettalen Ultraschalls durch Peer-Dozierende überlegen ist und wie die Technik von den Studierenden beurteilt wird.
Material und Methoden Insgesamt absolvierten 491 Studierende (342 Frauen, 149 Männer) eine curriculare Lehrveranstaltung zum Thema Gelenksonografie. Ausgesuchte Schnitte an Knie und Schulter wurden randomisiert auf konventionelle Weise und nach der 4-Schritt-Methode nach Peyton von speziell geschulten Peer-Dozierenden unterrichtet. Die erlernten Fertigkeiten wurden in einer Objective structured practical Examination (OSPE) geprüft. Beurteilt wurde die benötigte Zeit zum Einstellen der Schnitte, die technische Durchführung und die Bildqualität. Die Studierenden wurden gebeten, den Kurs zu evaluieren.
Ergebnisse Bezüglich der praktischen Ausführung und der Qualität der Schnittbilder zeigten sich die beiden Lehrmethoden sowohl für die Schulter- als auch für die Kniegelenksonografie als ebenbürtig. Der Vergleich der Lehrinhalte (Knie vs. Schulter) hatte signifikante Differenzen bezüglich der Bildauswertung (Knie 6,5 ± 1,7 Punkte, Schulter 6,0 ± 1,9 Punkte; p < 0,001), der benötigten Zeit (Knie 36 ± 21 s, Schulter 43 ± 20 s; p < 0,001) und des Erreichens der Bestehensgrenze von 60% (Knie: 73% der Studierenden, Schulter: 61% der Studierenden; p < 0,001) gezeigt. Unabhängig von der Lehrmethode bewerteten die Studierenden die Peer-Dozierenden als kompetent und befanden die Inhalte als adäquat für den Unterricht durch Gleichgestellte. Über 70% der Studierenden hatten Spaß an den Kursstunden. Sowohl der Knie- als auch der Schultergelenkkurs wurden im Mittel mit über 8 von 10 Punkten bewertet.
Schlussfolgerung Für die Vermittlung von Grundkenntnissen der Gelenksonografie sind die konventionelle Methode und die 4-Schritt-Methode nach Peyton ebenbürtig. Die Durchführung des Unterrichts durch Peer-Dozierende wird positiv bewertet und findet hohe Akzeptanz bei den Studierenden. Unterschieden im Schwierigkeitsgrad und der Komplexität der Lehrinhalte ist in künftigen Kursen Rechnung zu tragen.
Influence of Cranberry Extract on Tamm-Horsfall Protein in Human Urine and its Antiadhesive Activity Against Uropathogenic Escherichia coli
Authors: Scharf Birte , Sendker Jandirk , Dobrindt Ulrich , Hensel Andreas 
Published: October 2018

AbstractLC-MS characterized cranberry extract from the fruits of Vaccinium macrocarpon inhibited under in vitro conditions the bacterial adhesion of Escherichia coli strain 2980 uropathogenic E. coli (UPEC strains UTI89, NU14) to T24 bladder cells and adhesion of UPEC strain CFT073 to A498 kidney cells in a concentration-dependent manner. Within a biomedical study, urine samples from 16 volunteers (8 male, 8 female) consuming cranberry extract for 7 d (900 mg/d) were analyzed for potential antiadhesive activity against UPEC by ex vivo experiments. Results indicated inhibition of adhesion of UPEC strain UTI89 to human T24 bladder cells. Subgroup analysis proved significant inhibition of bacterial adhesion in case of urine samples obtained from male volunteers while female urine did not influence the bacterial attachment. Differences between antiadhesive capacity of urine samples from male/female volunteers were significant. Protein analysis of the urine samples indicated increased amounts of Tamm-Horsfall protein (THP, syn. uromodulin) in the active samples. Inhibition of bacterial adhesion by the urine samples was correlated to the respective amount of THP. As it is known that THP, a highly mannosylated glycoprotein, strongly interacts with FimH of UPEC, this will lead to a decreased interaction with uroplakin, a FimH-binding transmembrane protein of urothelial lining cells. From these data it can be concluded that the antiadhesive effect of cranberry after oral intake is not only related to the direct inhibition of bacterial adhesins by extract compounds but is additionally due to an induction of antiadhesive THP in the kidney.
Understanding Chinese EFL teachers’ conceptions and practices of assessment
Authors: Gan Zhengdong , Ieong Sylvia S. L. , Su Yuanlian , He Jinbo 
Published: October 2018

AbstractThis paper reports on findings from an ongoing research project exploring Chinese EFL teachers’ conceptions of assessment and their classroom assessment practices, as well as to examine the relationship between these two. The sample for the study consisted of 107 EFL teachers from 18 secondary schools who completed a Chinese version of the Teachers’ Conceptions of Assessment inventory (Brown, Hui, Yu, & Kennedy, 2011) and the Classroom Assessment Practices Questionnaire modified from Assessment Practices Inventory (Zhang & Burry-Stock, 2003). This study found that Chinese EFL teachers strongly associated assessment as a means of improving students’ EFL learning’ with assessment as a means of cultivating positive moral and personal character contributing to students’ lifelong learning and good citizenship. Results also showed that although there existed some level of alignment of teaching and assessment in the classroom, traditional assessment practices rather than alternative assessment such as student self-assessment were seen by the EFL teachers as contributing to students’ learning and making individual and school accountable, which is potentially a matter of some concern if innovative assessment reform that avoids using mandated external examinations is to be carried out in the Chinese EFL classroom. Implications of the results for Chinese EFL teacher assessment literacy development are also discussed
Old Chinese “west”: *snˤər
Authors: Nohara Masaki 
Published: October 2018

Abstract
This article aims to reconstruct the word “west” in Old Chinese phonology. In previous studies, since there was no sufficient evidence besides Chinese dialects, phonetic compounds, and phonetic loans, most scholars reconstructed its onset as *s-. One of the oldest dictionaries, Shuōwén jiězì 說文解字, includes two other written forms of 西 xī “west,” 卥 (Gǔwén 古文) and 卤 (Zhòuwén 籀文). This paper re-examines the reconstruction of the word 西 xī “west” and investigates the word 訊 xùn “to interrogate” seen in excavated documents. According to the Shuōwén, 訊 xùn also had another written form (
), which has the old form of 西 xī (卥). In other words, 西 xī and 訊 xùn must have had Xiéshēng connections (諧聲關係) at the time. Based on the resources from excavated documents such as oracle bone inscriptions and bronze scripts, 訊 xùn credibly has the character 人 rén as the phonetic element. This implies that 訊 xùn should have had the onset *sn- at the time; hence, it is concluded that the word “west” also had the onset *snˤ- in Old Chinese as well.
Deriving sluicing-like constructions in Isbukun Bunun
Authors: Wu Hsiao-hung Iris 
Published: October 2018

AbstractThis paper investigates the sluicing-like constructions (SLCs) in Isbukun Bunun, a language which always places itswh-words at the left-peripheral position, and it is argued that genuine sluicing is not available in this language. The evidence in favor of the pseudo-sluicing analysis draws on the behavior ofhow-phrases, the failure of implicit discourse anaphoric arguments and the absence of sloppy identity reading in Isbukun SLCs. These properties are otherwise hard to accommodate in a movement and deletion approach but rather follow from the view that SLCs in Isbukun Bunun are derived from independent syntactic operations includingpro-drop.
Definition as an argumentative strategy in parliamentary discourse
Authors: Hoinărescu Liliana 
Published: October 2018

Abstract
The present paper aims to investigate the main argumentative uses of definitions in various communicative contexts of the
parliamentary discourse, on the basis of two sets of data, selected from the British and the Romanian Parliaments. Relevant
categories of argumentative definitions are identified and described, by taking into consideration their linguistic structure and
rhetorical features, as well as their current association with other types of arguments and pragmatic strategies. The
cross-cultural and comparative perspective allows us to grasp to what extent the institutional forms, procedural rules and
cultural models can actually influence the argumentative choices and reasoning patterns in the specific cases of the British and
the Romanian Parliamentary discourse.
The theory myth
Authors: Weigand Edda 
Published: October 2018

Abstract
First of all, I would like to make clear that this paper is meant as a response to the attack against the Mixed
Game Model (Weigand 2010) launched by Harrissians in their articles of the Special
Issue of this journal (2018, 1). When I became aware of the fact that against their
dogmatic position no argument can take effect, I decided not to take part directly in such a pseudo-debate but to respond in a
discussion article in the next issue (see the preface of the special issue). I am writing this discussion article not in the
futile hope of changing the minds of Harrissian hardliners, but because I feel obliged to the other contributors of the Special
Issue who made a plea for the MGM. Moreover, I feel obliged to the readers of this journal to defend my position regarding basic
issues of linguistics. I’ll focus on central points and refer to my book on “Dialogue: The Mixed Game” for details.
Complex dynamic systems in students of interpreting training
Authors: Dong Yanping 
Published: October 2018

Abstract
Students of interpreting training may go through drastic cognitive changes, but current empirical findings are disparate and isolated. To integrate these findings and to obtain a better understanding of interpreting training, the present article tries to reinterpret students of interpreting training as complex dynamic systems. Relying primarily on longitudinal empirical data from several existing studies, the article illustrates how the initial state of some key parameters influences the progress of the systems, how the parameters themselves evolve, and how interpreting competence develops as a result of self-organization. The hope is that a metatheoretical framework such as Dynamic Systems Theory will allow specific findings and particularistic models for interpreting training to be integrated. Moreover, this approach may allow false dichotomies in the field to be overcome and seemingly contradictory data in empirical reports to be better understood, thereby providing guidelines for future research.
Bayesian variable selection for multivariate zero-inflated models: Application to microbiome count data
Authors: Lee Kyu Ha , Coull Brent A , Moscicki Anna-Barbara , Paster Bruce J , Starr Jacqueline R 
Published: October 2018

SummaryMicroorganisms play critical roles in human health and disease. They live in diverse communities in which they interact synergistically or antagonistically. Thus for estimating microbial associations with clinical covariates, such as treatment effects, joint (multivariate) statistical models are preferred. Multivariate models allow one to estimate and exploit complex interdependencies among multiple taxa, yielding more powerful tests of exposure or treatment effects than application of taxon-specific univariate analyses. Analysis of microbial count data also requires special attention because data commonly exhibit zero inflation, i.e., more zeros than expected from a standard count distribution. To meet these needs, we developed a Bayesian variable selection model for multivariate count data with excess zeros that incorporates information on the covariance structure of the outcomes (counts for multiple taxa), while estimating associations with the mean levels of these outcomes. Though there has been much work on zero-inflated models for longitudinal data, little attention has been given to high-dimensional multivariate zero-inflated data modeled via a general correlation structure. Through simulation, we compared performance of the proposed method to that of existing univariate approaches, for both the binary (“excess zero”) and count parts of the model. When outcomes were correlated the proposed variable selection method maintained type I error while boosting the ability to identify true associations in the binary component of the model. For the count part of the model, in some scenarios the univariate method had higher power than the multivariate approach. This higher power was at a cost of a highly inflated false discovery rate not observed with the proposed multivariate method. We applied the approach to oral microbiome data from the Pediatric HIV/AIDS Cohort Oral Health Study and identified five (of 44) species associated with HIV infection.
On the von Neumann entropy of graphs
Authors: Minello Giorgia , Rossi Luca , Torsello Andrea 
Published: October 2018

AbstractThe von Neumann entropy of a graph is a spectral complexity measure that has recently found applications in complex networks analysis and pattern recognition. Two variants of the von Neumann entropy exist based on the graph Laplacian and normalized graph Laplacian, respectively. Due to its computational complexity, previous works have proposed to approximate the von Neumann entropy, effectively reducing it to the computation of simple node degree statistics. Unfortunately, a number of issues surrounding the von Neumann entropy remain unsolved to date, including the interpretation of this spectral measure in terms of structural patterns, understanding the relation between its two variants and evaluating the quality of the corresponding approximations. In this article, we aim to answer these questions by first analysing and comparing the quadratic approximations of the two variants and then performing an extensive set of experiments on both synthetic and real-world graphs. We find that (1) the two entropies lead to the emergence of similar structures, but with some significant differences; (2) the correlation between them ranges from weakly positive to strongly negative, depending on the topology of the underlying graph; (3) the quadratic approximations fail to capture the presence of non-trivial structural patterns that seem to influence the value of the exact entropies; and (4) the quality of the approximations, as well as which variant of the von Neumann entropy is better approximated, depends on the topology of the underlying graph.
Toward safer health care: a review strategy of FDA medical device adverse event database to identify and categorize health information technology related events
Authors: Kang Hong , Wang Ju , Yao Bin , Zhou Sicheng , Gong Yang 
Published: October 2018

Abstract

Introduction
Health information technology (HIT) is intended to provide safer and better care to patients. However, poorly designed or implemented HIT poses a key risk to patient safety. It is essential for healthcare providers and researchers to investigate the HIT-related events. Unfortunately, the lack of HIT-related event databases in the community hinders the analysis and management of HIT-related events.

Objectives
Develop a standardized process for identifying HIT-related events from a Federal Drug Administration (FDA) database in order to create an HIT exclusive database for analysis and learning.

Methods
The FDA Manufacturer and User Facility Device Experience (MAUDE) database, containing over 7-million reports about medical device malfunctions and problems leading to serious injury or death, was considered as a potential resource to identify HIT-related events. We developed a strategy of identifying and categorizing HIT-related events from the FDA reports through the application of a keyword filter and standardized expert review. Ten percent identified reports were reviewed to measure the consistency among experts and to initialize a database for HIT-related events.

Results
With the proposed strategy, we initialized an HIT-related event database with over 3500 reports, and updated the estimation of the HIT-related event proportion in the FDA MAUDE database to 0.46∼0.69%, up to 50,000 HIT-related events.

Conclusion
The proposed strategy for HIT-related event identification holds promise in aiding the understanding, characterization, discovery, and reporting of HIT-related events toward improved patient safety. The analysis of contributing factors under the 8-dimensional sociotechnical model shows that hardware and software, clinical content, and human–computer interface were identified more frequently than the other dimensions.
OSL PROPERTIES IN VARIOUS FORMS OF KCl AND NaCl SAMPLES AFTER EXPOSURE TO IONIZING RADIATION
Authors: Majgier Renata , Rääf Christopher L , Mandowski Arkadiusz , Bernhardsson Christian 
Published: October 2018

Abstract
The aim of this work was to investigate the optically-stimulated luminescence (OSL) properties of potassium chloride (KCl) and its potential use in radiation dosimetry. The optimal condition for OSL readout with blue light stimulation were designated using a commercially available Risø TL/OSL reader. KCl was studied in three sample forms: crystals, powder and pellets. The following OSL characteristics were determined: signal reproducibility, OSL measurement-induced sensitivity changes, temperature dependence of OSL and signal stability over time. The results show a high reproducibility of KCl samples and strong sensitivity changes, which can be corrected for by using a test-dose. The long-term OSL studies confirmed the occurrence of both inverse fading and fading phenomena in KCl. In addition, a comparison with corresponding measurements using sodium chloride (NaCl) were carried out. Although it was confirmed that NaCl is more suitable for dosimetry, there might be benefits of combining NaCl with KCl for more accurate absorbed dose determinations.
Different Governments, Different Interests: The Gender Gap in Political Interest
Authors: Sánchez-Vítores Irene 
Published: October 2018

AbstractIn recent decades, differences between men and women have blurred in many social dimensions, including levels of educational attainment or access to the labor market. However, this increase in equality has not been reflected in a proportional reduction in the gender gap in political interest. This paper evaluates the extent of gender differences in political interest regarding different arenas, considering the moderating effect of marriage and caring for others using data from the Citizenship, Involvement, and Democracy Project. Although women generally find local politics more interesting than national politics, family, and caring responsibilities are still a source of disadvantage.