bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kids and Teens in Court (KTIC): A Model for Preparing Child Witnesses for Court
Authors: Peterson Leslie , Rolls Reutz Jennifer A. , Hazen Andrea L. , Habib Adrienne , Williams Rhonda 
Published: September 2019

AbstractEach year, numerous children testify in the United States in either criminal, civil, or juvenile court cases. Typically, children who testify are alleged victims of sexual or physical abuse or neglect, witnesses to violent crime, or subjects in custodial hearings in civil court. As more maltreatment cases are prosecuted and child custody is contested, an increasing number of children are being called as witnesses in court. Many of these children have already been traumatized by the experiences that led to their need to testify, and participation in the court process can have additional negative effects. This article describes the development and recent formative evaluation of a court preparation program that provides psychoeducation and utilizes components of evidence‐based trauma treatment approaches, such as relaxation and in vivo exposure, to support child witnesses and reduce the risk of retraumatization. Children and adolescents participating in the program attend group sessions conducted by mental health clinicians and complete a court‐related anxiety measure before and after each session. Results from 175 participants are reported. Findings indicated significant decreases in court‐related anxiety with large program effects. Challenges encountered by the program and future directions are discussed.
The association between anthropometric measures and physical performance in black adults of the North West Province, South Africa
Authors: Mamphwe Phumudzo , Kruger Herculina S. , Moss Sarah J. , Cockeran Marike , Ricci Cristian , Ukegbu Patricia O. , Kruger Iolanthé M. 
Published: September 2019

AbstractObjectiveThis study investigated associations between anthropometric measures and physical performance in black South African adults. It was hypothesized that noninvasive, simple anthropometric measurements, such as calf circumference (CC) and body mass index (BMI), may be useful predictors of physical performance and strength.MethodsBlack human immunodeficiency virus (HIV) negative men and women (aged 32‐93 years) participating in the Prospective Urban and Rural Epidemiology (PURE) study were enrolled at baseline in 2005 = 1428). Men and women's anthropometry, socio‐demographics and physical activity (PA) were assessed at baseline, 5‐ and 10‐year follow‐up. Physical performance (walk speed, chair stand and handgrip strength [HGS]) were assessed at 10‐year follow‐up. Linear regression models adjusted for potential confounders were used to evaluate the association between anthropometric measures and physical performance.ResultsThe combined overweight and obesity prevalence among both men (P = .02) and women (P < .001) increased significantly over 10 years, with significant increases over time in BMI and CC in the women, whereas PA decreased significantly over time in both men and women (P < .0001). BMI and CC were positively associated with HGS in the men (P = .02, P < .0001) and women (P < .0001), while CC was positively associated with walk speed in men only (P = .006) in the cross‐sectional analysis of 2015 measurements.ConclusionBMI and CC in both men and women were positively associated with HGS, but CC was associated with walk speed in the men only. Our study suggests that CC may be a useful predictor of physical performance in black men and to a limited extent in black women.
Prenatal diagnosis of micrognathia in 41 fetuses: Retrospective analysis of outcome and genetic etiologies
Authors: Mouthon Linda , Busa Tiffany , Bretelle Florence , Karmous‐Benailly Houda , Missirian Chantal , Philip Nicole , Sigaudy Sabine 
Published: September 2019

AbstractFetal micrognathia can be detected early in pregnancy. Prognosis of micrognathia depends on the risk of respiratory distress at birth and on the long‐term risk of intellectual disability. The purpose of this study was to evaluate the long‐term prognosis of fetuses with prenatal diagnosis of micrognathia by estimating the prevalence and the severity of confirmed genetic diagnosis in our cohort. Our retrospective study included 41 fetuses with prenatal diagnosis of micrognathia referred to the multidisciplinary centers for prenatal diagnosis in Nice and Marseille, France, between 2006 and 2016. Fetal micrognathia was associated with cleft palate in 27 cases. A genetic cause was confirmed in 21 cases (67%). A chromosomal abnormality was present in 12 cases, including three copy‐number variations diagnosed by array CGH. Monogenic disorders were identified in nine cases, most often after birth. Fetuses with family history of micrognathia or Pierre Robin sequence had a favorable outcome. Prognosis was good for the fetuses without associated findings and normal chromosomal analysis, with the exception of one case with a postnatal diagnosis of mandibulofacial dysostosis with microcephaly. Prognostic was poor for the fetuses with additional ultrasound anomalies, as only 5 out of 28 children had a good outcome. Prenatal diagnosis of micrognathia is an indicator of a possible fetal pathology justifying multidisciplinary management. Our study confirms the necessity of performing prenatal array CGH. Use of high‐throughput gene sequencing in prenatal period could improve diagnostic performance, prenatal counseling, and adequate postnatal care.
Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging
Authors: Vemuri Prashanthi , Lesnick Timothy G. , Knopman David S. , Przybelski Scott A. , Reid Robert I. , Mielke Michelle M. , Graff‐Radford Jonathan , Lowe Val J. , Machulda Mary M. , Petersen Ronald C. , Jack Clifford R. 
Published: September 2019

ObjectiveTo investigate the multifactorial processes underlying cognitive aging based on the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and resilience) influence longitudinal cognitive decline in each individual through worsening brain health.MethodsWe identified 1,230 elderly subjects (aged ≥50 years) with an average of 4.9 years of clinical follow‐up and with amyloid positron emission tomography, diffusion tensor imaging, and structural magnetic resonance imaging scans from the population‐based Mayo Clinic Study of Aging. We examined imaging markers of amyloid and brain health (white matter microstructural integrity and cortical thinning), systemic vascular health preceding the imaging markers, and early to midlife intellectual enrichment to predict longitudinal cognitive trajectories. We used latent growth curve models for modeling longitudinal cognitive decline.ResultsAll the pathways (amyloid, vascular, resilience) converged through their effects on cortical thinning and worsening cognition and together explained patterns in cognitive decline. Resilience and vascular pathways (aging process, sex differences, education/occupation, and systemic vascular health) had significant impact on white matter microstructural integrity. Education/occupation levels contributed to white matter integrity through systemic vascular health. Worsening white matter integrity contributed to significant cortical thinning and subsequently longitudinal cognitive decline. Baseline amyloidosis contributed to a significant proportion of cognitive decline that accelerated with longer follow‐up times, and its primary impact was through cortical thinning.InterpretationWe developed an integrated framework to help explain the dynamic and complex process of cognitive aging by considering key causal pathways. Such an approach is important for both better comprehension of cognitive aging processes and will aid in the development of successful intervention strategies. ANN NEUROL 2019;86:866–877
A Novel DNA Helical Wire Containing HgII‐Mediated T:T and T:G Pairs
Authors: Ono Akira , Kanazawa Hiroki , Ito Hikari , Goto Misato , Nakamura Koudai , Saneyoshi Hisao , Kondo Jiro 
Published: September 2019

AbstractNumerous applications of metal‐mediated base pairs (metallo‐base‐pairs) to nucleic acid based nanodevices and genetic code expansion have been extensively studied. Many of these metallo‐base‐pairs are formed in DNA and RNA duplexes containing Watson–Crick base pairs. Recently, a crystal structure of a metal–DNA nanowire with an uninterrupted one‐dimensional silver array was reported. We now report the crystal structure of a novel DNA helical wire containing HgII‐mediated T:T and T:G base pairs and water‐mediated C:C base pairs. The Hg‐DNA wire does not contain any Watson–Crick base pairs. Crystals of the Hg‐DNA wire, which is the first DNA wire structure driven by HgII ions, were obtained by mixing the short oligonucleotide d(TTTGC) and HgII ions. This study demonstrates the potential of metallo‐DNA to form various structural components that can be used for functional nanodevices.
Adsorption behavior and kinetics of CO2 on amine‐functionalized hyper‐crosslinked polymer
Authors: Liu Fenglei , Fu Wenhao , Chen Shuixia 
Published: September 2019

ABSTRACTA hyper‐crosslinked polymer (XAD‐4‐pc) was developed by modifying the commercial polystyrene resin (XAD‐4) through a Friedel–Crafts reaction, followed by impregnation with polyethyleneimine (PEI) for CO2 capture. The physicochemical properties of the as‐synthesized adsorbents were analyzed by different characterization techniques, and the adsorption behavior of CO2 on these adsorbents was evaluated in a self‐assembled adsorption setup with gas chromatography. Experimental results found that the Brunauer–Emmett–Teller surface area and pore volume of XAD‐4‐pc were significantly higher than that of XAD‐4, which was favorable to the improvement of PEI loading and CO2 adsorption. The maximum CO2 uptake for PEI‐functionalized XAD‐4‐pc was 3.24 mmol g−1 at 25 °C. The adsorption isotherm of CO2 on the adsorbent was well described by the Langmuir equation, and the kinetics data could be accurately described by Avrami model over the entire adsorption range. The diffusion mechanism study showed that the film diffusion and intraparticle diffusion were mainly the rate‐limiting steps. Moreover, this adsorbent could be well regenerated at relatively low temperature and exhibited stable regenerability after five adsorption‐regeneration cycles, showing its high potential for the capture of CO2 from flue gases. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48479.
Size‐Dependent Vulnerability of Lumbar Motor Neuron Dendritic Degeneration in SOD1G93A Mice
Authors: Fogarty Matthew J. , Mu Erica W.H. , Lavidis Nickolas A. , Noakes Peter G. , Bellingham Mark C. 
Published: September 2019

ABSTRACTThe motor neuron (MN) soma surface area is correlated with motor unit type. Larger MNs innervate fast fatigue‐intermediate (FInt) or fast‐fatiguable (FF) muscle fibers in type FInt and FF motor units, respectively. Smaller MNs innervate slow‐twitch fatigue‐resistant (S) or fast fatigue‐resistant (FR) muscle fibers in type S and FR motor units, respectively. In amyotrophic lateral sclerosis (ALS), FInt and FF motor units are more vulnerable, with denervation and MN death occurring for these units before the more resilient S and FR units. Abnormal MN dendritic arbors have been observed in ALS in humans and rodent models. We used a Golgi‐Cox impregnation protocol to examine soma size‐dependent changes in the dendritic morphology of lumbar MNs in SOD1G93A mice, a model of ALS, at pre‐symptomatic, onset and mid‐disease stages. In wildtype control mice, the relationship between MN soma surface area and dendritic length or dendritic spine number was highly linear (i.e., increased MN soma size correlated with increased dendritic length and spines). By contrast, in SOD1G93A mice, this linear relationship was lost and dendritic length reduction and spine loss were observed in larger MNs, from pre‐symptomatic stages onward. These changes correlated with the neuromotor symptoms of ALS in rodent models. At presymptomatic ages, changes were restricted to the larger MNs, likely to comprise vulnerable FInt and FF motor units. Our results suggest morphological changes of MN dendrites and dendritic spines are likely to contribute ALS pathogenesis, not compensate for it. Anat Rec, 303:1455–1471, 2020. © 2019 American Association for Anatomy
The Ontogeny of Masticatory Muscle Architecture in Microcebus murinus
Authors: Leonard Kaitlyn C. , Boettcher Marissa L. , Dickinson Edwin , Malhotra Neha , Aujard Fabienne , Herrel Anthony , Hartstone‐Rose Adam 
Published: September 2019

ABSTRACTThe masticatory apparatus has been the focus of many studies in comparative anatomy—especially analyses of skulls and teeth, but also of the mandibular adductor muscles which are responsible for the production of bite force and the movements of the mandible during food processing and transport. The fiber architecture of these muscles has been correlated to specific diets (e.g., prey size in felids) and modes of foraging (e.g., tree gouging in marmosets). Despite the well‐elucidated functional implications of this architecture, little is known about its ontogeny. To characterize age‐related myological changes, we studied the masticatory muscles in a large (n = 33) intraspecific sample of a small, Malagasy primate, Microcebus murinus including neonatal through geriatric individuals. We removed each of the mandibular adductors and recorded its mass as well as other linear measurements. We then chemically dissected each muscle to study its architecture—fascicle length and physiological cross‐sectional area (PCSA) which relate to stretch (gape) and force capabilities, respectively. We observed PCSA and muscle mass to increase rapidly and plateau in adulthood through senescence. Fascicle lengths remained relatively constant once maximal length was reached, which occurred early in life, suggesting that subsequent changes in PCSA are driven by changes in muscle mass. Quadratic curvilinear models of each of the architectural variables of all adductors combined as well as individual muscles regressed against age were all significant. Anat Rec, 303:1364–1373, 2020. © 2019 American Association for Anatomy
Nanoreactors for Chemical Synthesis and Biomedical Applications
Authors: Zhou Hua , Tan Jingyun , Zhang Xuanjun 
Published: September 2019

AbstractWith the rapid development of nanoscience and nanotechnology, various types of functional nanoreactors have been designed for diverse applications. Here, the recent evolution of the rational design of nanoreactors for chemical synthesis and biomedical applications are briefly summarized and discussed. The presence of nanoreactors provides constrained space isolated from the surrounding environment. Scientists are committed to studying changes in chemical reactions when the reaction system is confined to the nanosized space. Nanoreactors accelerate the reaction rate and even change mechanism of some chemical reactions. Cells and organelles as natural nanoreactors are also discussed. The development of intracellular synthesis makes it possible to realize various applications in biomedicine. The challenges on the rational design of nanoreactors and perspectives are also discussed.
Augmented TP model transformation‐based parallel distributed compensation control design
Authors: Zhao Guoliang , Wang Degang 
Published: September 2019

AbstractThe usual sampled hyper grid points of uniform sampling method are distributed equally in the TP model transformation, thus, the sampling results often omit the local extrema when the sampling step is not fine‐tuned. Then the resultant tensor which is used for controller design can not fully cover the state space, although the gain which is the feasible solution of the linear matrix inequalities. In this paper, we proposed a non‐uniform sampling method for tensor product model transformation, local extrema are considered in the sampling step, while the sampling step can vary dynamically for different function entries. In this paper, TP model transformation‐based parallel distributed compensation (PDC) controller is extended in three folds: (i) The existing TP model transformation‐based PDC controller with uniform sampling method is extended to TP model transformation‐based PDC tracking controller with the uniform sampling method and an extended signal. (ii) A new TP model transformation‐based PDC tracking controller is proposed based on a new sampling method, that is, the Hammersley sampling method. (iii) TP model transformation‐based PDC tracking controller is also proposed based on the non‐uniform sampling method. The proposed adaptive TP model transformation‐based PDC tracking controller is able to enhance the performance of the TP model transformation‐based PDC controller, and the adaptive TP model transformation‐based PDC controller obtains the best results due to the nearly exact sampling of the system.
Back‐stepping stabilization of fractional‐order triangular system with applications to chaotic systems
Authors: Peng Chenchen , Zhang Weihai 
Published: September 2019

AbstractThis paper addresses the stabilization of fractional‐order nonlinear lower triangular systems and applies the obtained results to the synchronization of fractional‐order chaotic systems (FOCSs). Three cases are considered as follows: (i) FOCSs have a lower triangular structure themselves. (ii) FOCSs can be converted into the form in full by appropriate nonsingular coordinate transformations. (iii) FOCSs can be transformed into the structure in part by the conversions. It is shown that the above three cases combining with back‐stepping approach are useful for the control of FOCSs. Different from the previous literature, the system structure studied is more concise with more applications. A numerical example is presented to show the validity of the proposed results.
Decompositions of finite games: From weighted inner product to standard inner product
Authors: Li Changxi , He Fenghua , Yao Haodi 
Published: September 2019

AbstractTo investigate the topological structure of finite games, various decomposions of finite games have been proposed. The inner product of vectors plays a key role in the decomposition of finite games. This paper considers the effect of different inner products on the orthogonal decomposition of finite games. We found that only when the compatible condition is satisfied, a common decomposition can be induced by the standard inner product and the weighted inner product simultaneously. To explain the result, we studied the existing decompositions, including potential based decomposition, zero‐sum based decomposition, and normalization based decomposition. For zero‐sum based decomposition and normalization based decomposition, we redefine their subspaces in a linear algebraic framework, which shows their physical meanings clearly. Bases of subspaces in these two decompositions are constructed.
From three‐dimensional morphology to effective diffusivity in filamentous fungal pellets
Authors: Schmideder Stefan , Barthel Lars , Müller Henri , Meyer Vera , Briesen Heiko 
Published: September 2019

AbstractFilamentous fungi are exploited as cell factories in biotechnology for the production of proteins, organic acids, and natural products. Hereby, fungal macromorphologies adopted during submerged cultivations in bioreactors strongly impact the productivity. In particular, fungal pellets are known to limit the diffusivity of oxygen, substrates, and products. To investigate the spatial distribution of substances inside fungal pellets, the diffusive mass transport must be locally resolved. In this study, we present a new approach to obtain the effective diffusivity in a fungal pellet based on its three‐dimensional morphology. Freeze‐dried Aspergillus niger pellets were studied by X‐ray microcomputed tomography, and the results were reconstructed to obtain three‐dimensional images. After processing these images, representative cubes of the pellets were subjected to diffusion computations. The effective diffusion factor and the tortuosity of each cube were calculated using the software GeoDict. Afterwards, the effective diffusion factor was correlated with the amount of hyphal material inside the cubes (hyphal fraction). The obtained correlation between the effective diffusion factor and hyphal fraction shows a large deviation from the correlations reported in the literature so far, giving new and more accurate insights. This knowledge can be used for morphological optimization of filamentous pellets to increase the yield of biotechnological processes.
Taking sustainable fashion mainstream: Social media and the institutional celebrity entrepreneur
Authors: McKeown Carolyn , Shearer Linda 
Published: September 2019

AbstractThere is a growing imperative to address the negative environmental impact of fashion and an increased awareness of sustainability issues: the sustainable fashion concept (SFC). However, while consumers are becoming more aware and concerned about sustainability, this is not resulting in the purchase of sustainable fashion products in preference to “mainstream” goods. This so‐called attitude–behaviour gap is well documented in academic literature, and yet there is a lack of research into potential methods of disrupting this phenomenon. This study seeks to redress this by examining the potential influence of celebrity institutional entrepreneurs (CIEs) to raise awareness of the SFC and to therefore guide and change consumer behaviour towards more sustainable practice. CIEs are celebrities who use their social position to espouse their values with the intention of influencing institutional habits and behaviours. In this case, Emma Watson is identified as an appropriate and credible proponent, and her @the_press_tour Instagram account was used to examine her influence. A netnographic investigation of this account was conducted in combination with eight in‐depth interviews with account followers to examine attitudes and actions towards sustainable fashion. Findings showed that the account had partial impact on consumer engagement with the SFC in that it led to the participants being more likely to discuss and consider the issues around sustainable fashion; however, it had no significant impact on purchases of sustainable fashion. The study concludes that CIEs can impact the attitudes of mainstream consumers towards sustainable fashion; however, further research is required to determine any long‐term influence.
Insights into the Role of Ketoreductases in the Biosynthesis of Partially Reduced Bacterial Aromatic Polyketides*
Authors: Husain Syed Masood , Präg Andreas , Linnenbrink Anton , Bechthold Andreas , Müller Michael 
Published: September 2019

AbstractPartially reduced aromatic polyketides are bioactive secondary metabolites or intermediates in the biosynthesis of deoxygenated aromatics. For the antibiotic GTRI‐02 (mensalone) in different Streptomyces spp., biosynthesis involving the reduction of a fully aromatized acetyltrihydroxynaphthalene by a naphthol reductase has been proposed and shown in vitro with a fungal enzyme. However, more recently, GTRI‐02 has been identified as a product of the ActIII biosynthetic gene cluster from Streptomyces coelicolor A3(2), for which the reduction of a linear polyketide precursor by ActIII ketoreductase, prior to cyclization and aromatization, has been suggested. We have examined three different ketoreductases from bacterial producer strains of GTRI‐02 for their ability to reduce mono‐, bi‐, and tricyclic aromatic substrates. The enzymes reduced 1‐ and 2‐tetralone but not other aromatic substrates. This strongly suggests a reduction of a cyclized but not yet aromatic polyketide intermediate in the biosynthesis of GTRI‐02. Implications of the results for the biosynthesis of other secondary polyketidic metabolites are discussed.