bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long persistent and photo‐stimulated luminescence in Pr3+‐doped layered perovskite phosphor for optical data storage
Authors: Wang Bo , Li Xiaoshuang , Chen Yeqing , Chen Yan , Zhou Jiangcong , Zeng Qingguang 
Published: April 2018

AbstractAs the time for big data is coming, the demand for data's storage density and capacity exerts explosive growth. However, traditional optical storage is hard to get rid of the bottleneck of optical diffraction limit. The persistent luminescence materials could be used for optical data storage based on the photon trapping and de‐trapping mode. Herein the performance of thermoluminescence (TL), photo‐stimulated luminescence, and photoluminescence of Pr3+‐doped Ca4Ti3O10 were studied in order to explore the optical storage property of this material. The TL glow curves show that the deep‐trap in Ca4Ti3O10:0.01Pr3+, Y3+ has a narrow distribution from 0.9 to 0.98 eV, which is qualified for maintaining the recorded data at RT for a long duration time. NIR photo‐stimulated red persistent luminescence (NIR‐to‐red mode) as presented in the Y‐containing Ca4Ti3O10:Pr3+ phosphor could be a promising technique for optical data storage.
TEAD4 exerts pro‐metastatic effects and is negatively regulated by miR6839‐3p in lung adenocarcinoma progression
Authors: Zhang Qun , Fan Hang , Zou Qian , Liu Hongda , Wan Bing , Zhu Suhua , Hu Yangbo , Li Huijuan , Zhang ChenXi , Zhou Li , Zhu Qingqing , Xiao Kunhong , Zhang Jianya , Zhan Ping , Lv Tangfeng , Song Yong 
Published: April 2018

AbstractSeveral studies have shown the tumorigenesis role of transcriptional enhancer associate domain (TEAD) proteins; here, we initially explored expression, function and signalling mechanisms of TEAD4 in lung adenocarcinoma (LAD). Both the mRNA and protein levels of TEAD4 were increased in LAD tissues than those in adjacent nontumourous tissues. Besides, database search indicated a poorer clinical outcome in LAD patients with higher TEAD4 expression, revealing its potential tumour‐promoting role. Therefore, we conducted cellular experiments to further investigate its effect on tumour phenotypes. Accordingly, TEAD4 showed little impact on LAD cell cycle, proliferation, or apoptosis. However, silencing TEAD4 remarkably attenuated cell migration and invasion capacities. Consistently, several important epithelial‐mesenchymal transition (EMT) markers such as E‐cadherin and Slug were consequently altered by silencing TEAD4. Furthermore, we identified a novel TEAD4‐targeted microRNA, namely miR6839‐3p, and confirmed its function in suppressing TEAD4 expression. Finally, the impact of overexpressing miR6839‐3p mimics on LAD progression was validated, which showed a similar pattern with TEAD4 knockdown cells. Taken together, our data not only revealed the significant role of TEAD4 in promoting LAD progression and predicting clinical outcome but also distinguished miR6839‐3p mimics as a promising therapeutic direction.
Long working hours and skipping breakfast concomitant with late evening meals are associated with suboptimal glycemic control among young male Japanese patients with type 2 diabetes
Authors: Azami Yasushi , Funakoshi Mitsuhiko , Matsumoto Hisashi , Ikota Akemi , Ito Koichi , Okimoto Hisashi , Shimizu Nobuaki , Tsujimura Fumihiro , Fukuda Hiroshi , Miyagi Chozi , Osawa Sayaka , Osawa Ryo , Miura Jiro 
Published: April 2018

AbstractAims/IntroductionTo assess the associations of working conditions, eating habits and glycemic control among young Japanese workers with type 2 diabetes.Materials and MethodsThis hospital‐ and clinic‐based prospective study included 352 male and 126 female working patients with diabetes aged 20–40 years. Data were obtained from June to July 2012 and June to July 2013. Logistic regression analysis was used to estimate multivariable‐adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for suboptimal glycemic control (glycosylated hemoglobin level of ≥7%) obtained from June to July 2013.ResultsMultivariable logistic regression analysis showed that disease duration of ≥10 years (OR 2.43, 95% CI 1.02–5.80), glycosylated hemoglobin level of ≥7% in 2012 (OR 8.50, 95% CI 4.90–14.80), skipping breakfast and late evening meals (OR 2.50, 95% CI 1.25–5.00) and working ≥60 h/week (OR 2.92, 95% CI 1.16–7.40) were predictive of suboptimal glycemic control in male workers, whereas a glycosylated hemoglobin level of ≥7% in 2012 (OR 17.96, 95% CI 5.93–54.4), oral hyperglycemic agent therapy (OR 12.49, 95% CI 2.75–56.86) and insulin therapy (OR 11.60, 95% CI 2.35–57.63) were predictive of suboptimal glycemic control in female workers.ConclusionsWorking ≥60 h/week and habitual skipping breakfast concomitant with late evening meals might affect the ability of young male workers with type 2 diabetes to achieve and maintain glycemic control.
Diet quality and 10‐year healthcare costs by BMI categories in the mid‐age cohort of the Australian Longitudinal Study on Women's Health
Authors: Patterson A. , Hure A. , Burrows T. , Jackson J. , Collins C. 
Published: April 2018

AbstractBackgroundBetter diets, as evaluated by diet quality indices, are associated with lower rates of morbidity and mortality. Although governments and researchers alike recognise the burden that obesity incurs for increased healthcare spending, there is insufficient evidence for the role of diet quality on healthcare costs.MethodsDiet quality was assessed by the Australian Recommended Food Score (ARFS) for 6328 women aged 50–55 years from the Australian Longitudinal Study on Women's Health. The ARFS was ranked by quintile, and 10‐year cumulative data on healthcare costs from Medicare (Australia's Universal healthcare cover) were reported by body mass index category, using generalised linear modelling.ResultsHealthy weight women with the highest diet quality were found to make significantly fewer Medicare claims (P = 0.012) compared to those with the lowest diet quality. In healthy weight and overweight women, the number of healthcare claims and charges was inversely associated with consuming a greater variety of vegetables. For every 1 point increase in the ARFS vegetable component score, healthy weight women made 1.9 fewer healthcare claims and were charged $139 less, whereas overweight women made 2.3 fewer claims and were charged $176 less for healthcare over 10 years.ConclusionsThe results of the present study support the need to prioritise an improved diet quality with the aim of reducing healthcare claims and overall costs in a population‐based sample of Australian females. As the burden of overweight and obesity on the healthcare system increases, strategies to improve diet quality may be of particular importance; however, more research is required to further establish this relationship.
bHLH104 confers tolerance to cadmium stress in Arabidopsis thaliana
Authors: Yao Xiani , Cai Yuerong , Yu Diqiu , Liang Gang 
Published: April 2018

AbstractCd is a non‐essential heavy metal that is toxic to both plants and animals. Here, we reveal that the transcription factor bHLH104 positively regulates Cd tolerance in Arabidopsis thaliana. We show that Fe deficiency‐responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss‐of‐function mutants, but enhanced upon overexpression of bHLH104. Correspondingly, the bhlh104 mutants displayed sensitivity to Cd stress, whereas plants overexpressing bHLH104 exhibited enhanced Cd tolerance. Further analysis suggested that bHLH104 positively regulates four heavy metal detoxification‐associated genes, IREG2, MTP3, HMA3 and NAS4, which play roles in Cd sequestration and tolerance. The bHLH104 overexpression plants accumulated high levels of Cd in the root but low levels of Cd in the shoot, which might contribute to the Cd tolerance in those lines. The present study thus points to bHLH104 as a potentially useful tool for genetic engineering of plants with enhanced Cd tolerance.
Plant glycosylphosphatidylinositol anchored proteins at the plasma membrane‐cell wall nexus
Authors: Yeats Trevor H. , Bacic Antony , Johnson Kim L. 
Published: April 2018

AbstractApproximately 1% of plant proteins are predicted to be post‐translationally modified with a glycosylphosphatidylinositol (GPI) anchor that tethers the polypeptide to the outer leaflet of the plasma membrane. Whereas the synthesis and structure of GPI anchors is largely conserved across eukaryotes, the repertoire of functional domains present in the GPI‐anchored proteome has diverged substantially. In plants, this includes a large fraction of the GPI‐anchored proteome being further modified with plant‐specific arabinogalactan (AG) O‐glycans. The importance of the GPI‐anchored proteome to plant development is underscored by the fact that GPI biosynthetic null mutants exhibit embryo lethality. Mutations in genes encoding specific GPI‐anchored proteins (GAPs) further supports their contribution to diverse biological processes, occurring at the interface of the plasma membrane and cell wall, including signaling, cell wall metabolism, cell wall polymer cross‐linking, and plasmodesmatal transport. Here, we review the literature concerning plant GPI‐anchored proteins, in the context of their potential to act as molecular hubs that mediate interactions between the plasma membrane and the cell wall, and their potential to transduce the signal into the protoplast and, thereby, activate signal transduction pathways.
Tai Chi Improves Brain Metabolism and Muscle Energetics in Older Adults
Authors: Zhou Min , Liao Huijun , Sreepada Lasya P. , Ladner Joshua R. , Balschi James A. , Lin Alexander P. 
Published: April 2018

ABSTRACTBACKGROUND AND PURPOSETai Chi is a mind‐body exercise that has been shown to improve both mental and physical health. As a result, recent literature suggests the use of Tai Chi to treat both physical and psychological disorders. However, the underlying physiological changes have not been characterized. The aim of this pilot study is to assess the changes in brain metabolites and muscle energetics after Tai Chi training in an aging population using a combined brain‐muscle magnetic resonance spectroscopy (MRS) examination.METHODSSix healthy older adults were prospectively recruited and enrolled into a 12‐week Tai Chi program. A brain 1H MRS and a muscle 31P MRS were scanned before and after the training, and postprocessed to measure N‐acetylaspartate to creatine (NAA/Cr) ratios and phosphocreatine (PCr) recovery time. Wilcoxon‐signed rank tests were utilized to assess the differences between pre‐ and post‐Tai Chi training.RESULTSA significant within‐subject increase in both the NAA/Cr ratios (P = .046) and the PCr recovery time (P = .046) was observed between the baseline and the posttraining scans. The median percentage changes were 5.38% and 16.51% for NAA/Cr and PCr recovery time, respectively.CONCLUSIONSOur pilot study demonstrates significant increase of NAA/Cr ratios in posterior cingulate gyrus and significantly improved PCr recovery time in leg muscles in older adults following short‐term Tai Chi training, and thus provides insight into the beneficial mechanisms.
The Ability of Face Viewpoint Transformation Remains Immature at Age of 12: Evidence from Recognition of Faces with Different Familiarity in Children
Authors: Yang Jisien , Schwaninger Adrian 
Published: April 2018

AbstractChildren are immature in face recognition, particularly in face configural decoding. This study examines the developmental difference of face recognition in another mechanism: viewpoint transformation processing. Adults and sixth‐grade children were instructed to match a series of one‐tone black face silhouettes to their corresponding front‐view faces. This task involves sophisticated calculation in pictorial information, precise viewpoint transformation, and most probably a 3‐D face representation. The results showed that although the performances were well above chance level in the recognition of familiar faces, for children, they were at chance level in the recognition of unfamiliar faces. The results indicate that children, at least to the age of about 12 years, are still immature in the processing of face viewpoint transformation compared to adults.
Does Biofloc Improve the Energy Distribution and Final Muscle Quality of Shrimp, Litopenaeus vannamei (Boone, 1883)?
Authors: Chan‐Vivas Elisa , Edén Magaña‐Gallegos , Maldonado Carlos , Escalante Karla , Gaxiola Gabriela , Cuzon Gerard 
Published: April 2018

AbstractIn a 45‐d experiment, Litopenaeus vannamei was cultured in two treatments, biofloc technology or clear water recirculating aquaculture system, to evaluate the effect on growth and survival, energy balance, and texture of the marketable product. The experimental design consisted of 40 plastic tanks of 54 L (20 tanks per treatment), with a density of 140 organisms/m3 in each culture system. The final body weight, daily growth coefficient, and survival were significantly higher (P < 0.05) in biofloc technology (12.40 g, 5.0%g/d, and 87.1%, respectively) than in the clear water system (7.0 g, 1.4%g/d, and 74.2%). The retained energy and energy content of exuviae were significantly higher for shrimp in the biofloc technology (448.5 ± 36.4 and 22.4 ± 1.8 J/shrimp/d, respectively) than in clear water (246.3 ± 40.9 and 12.3 ± 2.0 J/shrimp/d, respectively). Routine metabolism was significantly higher for the clear water treatment (411.4 ± 123.8 J/shrimp/d). Shear force was higher in the biofloc technology, indicating greater muscle firmness; this matched the gel electrophoresis patterns of the proteins extracted from the muscle tissues. This suggests that biofloc technology could be used not only to improve growth and survival in L. vannamei but also to enhance the final product quality and acceptability in the market.
The Beauty of God
Authors: Tietz Christiane 
Published: April 2018

AbstractWhile in the theology of the ancient Church the idea that God is beautiful was the object of some kind of consensus, Protestant dogmatics usually would not contain a chapter about God's beauty. The paper examines why this is the case. It brings Christian thinking about God's beauty in dialogue with current aesthetic observations about beauty, with the emphasis on God's beauty in Islam. Finally, it discusses Karl Barth's interest in God's beauty as this characteristic of God expresses how God is attractive for human beings.
The Justice of God
Authors: Muis Jan 
Published: April 2018

AbstractThis article analyzes the views on God's justice of Albrecht Ritschl, Hermann Cremer, Karl Barth, and Eberhard Jüngel, which presuppose that God's essence is love and that the justification of the sinner reveals God's justice. Four problems with this approach are discussed: its essentialist framework; its understanding of God's divinity as love; its neglect of other forms of God's justice; its one‐sided interpretation of the biblical notion of justice. On the basis of the variety of God's just acts in relation to a variety of people, an alternative understanding of God's justice is proposed, in which God's attributes are understood as distinct identity‐defining properties of himself.
Case of acromegalic myopathy and arthropathy long after trans‐sphenoidal surgery
Authors: Sasaki Ryo , Yamashita Toru , Takahashi Yoshiaki , Sato Kota , Takemoto Mami , Hishikawa Nozomi , Ohta Yasuyuki , Abe Koji 
Published: April 2018

AbstractAcromegaly patients usually show impaired vision, the enlargement of hands and feet, heart failure, and diabetes and rarely show myopathy (weakness and muscle pain) and arthropathy (joint pain). Here, we report an acromegaly patient who showed progressive myopathy and arthropathy long after a Hardy operation. The symptoms of myopathy and arthropathy occurred under normal GH and high IGF‐1 levels, but these symptoms improved when the IGF‐1 level was normalized by a treatment of octreotide with an increased dose of 30–40 mg. Thus, strict and immediate control of IGH‐1 may be pivotally important to prevent and treat acromegalic myopathy and arthropathy.
Progressive multifocal leukoencephalopathy with immune reconstitution inflammatory syndrome following treatment for granulomatosis with polyangiitis
Authors: Sasaki Fuyuko , Oyama Genko , Fujimaki Motoki , Yokoyama Kazumasa , Ogasawara Michihiro , Nakamichi Kazuo , Saijo Masayuki , Takasaki Yoshinari , Hattori Nobutaka 
Published: April 2018

AbstractA 56‐year‐old man with granulomatosis with polyangiitis (GPA) developed progressive multifocal leukoencephalopathy (PML) after a combined immune therapy with methotrexate and prednisolone. Despite negative conversion of JC virus after cessation of methotrexate treatment and tapering of prednisone, he developed amnestic aphasia, left hemispatial neglect, and left hemiplegia, which was confirmed as immune reconstitution inflammatory syndrome (IRIS) based on a rapid expansion of the lesions bilaterally with marginal gadolinium enhancement on brain magnetic resonance imaging. This case suggests that it may be important to be aware of possibility of IRIS, in cases of worsening neurological symptoms despite discontinuation of immunosuppressive treatments for GPA with PML.
Clinicopathological significance of miR‐26, miR‐107, miR‐125b, and miR‐203 in head and neck carcinomas
Authors: González‐Arriagada WA , Olivero P , Rodríguez B , Lozano‐Burgos C , de Oliveira CE , Coletta RD 
Published: April 2018

ObjectivesMicroRNAs play a role in the development and progression of head and neck squamous cell carcinomas (HNSCC). Our aim was to study the expression of miR‐26, miR‐107, miR‐125b, and miR‐203 in primary HNSCC with and without lymph node metastasis and their clinicopathological significance.Materials and MethodsThe expression of microRNAs in primary HNSCC with lymph node metastasis (n = 16) and their matched lymph node, as well as primary tumors without metastasis (n = 16), were determined by quantitative RT‐PCR and analyzed with clinicopathological features and survival.ResultsThe expression levels of miR‐26 (p < .05) and miR‐125b (p < .01) were higher in metastatic primary HNSCC, while levels of miR‐203 (p < .01) were lower. The expression of the microRNAs was associated with clinicopathological features, including miR‐26 high expression and N stage (p = .04), poor differentiation (p = .005) and recurrence (p = .007), miR‐125b high expression and N stage (p = .0005) and death (p = .02), and low levels of miR‐203 and N stage (p = .04). The high expression of miR‐26 was associated with shortened disease‐free survival, and high miR‐125b expression was an independent risk factor for poor disease‐specific survival.ConclusionsThese findings suggest that miR‐26 and miR‐125b may be associated with the progression and metastasis of HNSCC and that miR‐203 is associated with a more favorable prognosis.
Evaluation of a nursing student health fair program: Meeting curricular standards and improving community members' health
Authors: Salerno John P. , McEwing Evan , Matsuda Yui , Gonzalez‐Guarda Rosa M. , Ogunrinde Olutola , Azaiza Mona , Williams Jessica R. 
Published: April 2018

AbstractBackgroundPublic health nursing (PHN) is an essential component of baccalaureate nursing education. In order to build PHN competencies, universities must design and operationalize meaningful clinical activities addressing community and population health. Currently, there is a paucity of literature delineating best practices for promoting competency in PHN.AimsThe purpose of this manuscript is to describe a PHN‐student health fair program as a means for meeting undergraduate PHN curricular standards, and to report results of an evaluation conducted examining its effectiveness in improving community member's health knowledge.MethodsHealth fairs were held at community agencies that served the homeless or victims of intimate partner violence. A total of 113 community members that attended a health fair were assessed at baseline and immediate posttest using open‐ended questionnaires. The design of the health fairs included a community assessment, intervention, and evaluation flow that followed the nursing process.ResultsWe report that results from participants surveyed indicated that PHN‐student delivered health fairs improved health knowledge among community members in this sample (p = .000).ConclusionHealth fairs conducted by PHN students appear to be promising community health promotion and disease prevention interventions that can serve as an effective strategy for teaching PHN student competencies and facilitating engagement with the community.
Epidemiology, risk factors and outcomes of invasive aspergillosis in solid organ transplant recipients in the Swiss Transplant Cohort Study
Authors: Neofytos D. , Chatzis O. , Nasioudis D. , Boely Janke E. , Doco Lecompte T. , Garzoni C. , Berger C. , Cussini A. , Boggian K. , Khanna N. , Manuel O. , Mueller N.J. , van Delden C. ,   Swiss Transplant Cohort Study
Published: April 2018

AbstractBackgroundThere is lack of recent multicenter epidemiological data on invasive aspergillosis (IA) among solid organ transplant recipient (SOTr) in the mold‐acting antifungal era. We describe the epidemiology and outcomes of IA in a contemporary cohort of SOTr using the Swiss Transplant Cohort Study.MethodsAll consecutive SOTr with proven or probable IA between 01.05.2008 and 31.12.2014 were included. A case‐control study to identify IA predictors was performed: 1‐case was matched with 3‐controls based on SOT type, transplant center, and time post‐SOT.ResultsAmong 2868 SOTr, 70 (2.4%) patients were diagnosed with proven (N: 30/70, 42.9%) or probable (N: 40/70, 57.1%) IA. The incidence of IA was 8.3%, 7.1%, 2.6%, 1.3%, and 1.2% in lung, heart, combined, kidney, and liver transplant recipients, respectively, Galactomannan immunoassay was positive in 1/3 of patients tested. Only 33/63 (52.4%) of patients presented with typical pulmonary radiographic findings. Predictors of IA included: renal insufficiency, re‐operation, and bacterial and viral infections. 12‐week mortality was higher in liver (85.7%, 6/7) compared to other (15.9%, 10/63; P < .001) SOTr.ConclusionsInvasive aspergillosis remains a rare complication post‐SOT, with atypical radiographic presentations and low positivity rates of biomarkers posing significant diagnostic challenges. Although overall mortality has decreased in SOTr, it remains high in liver SOTr.
Nocardia infections in the transplanted host
Authors: Hemmersbach‐Miller Marion , Stout Jason E. , Woodworth Michael H. , Cox Gary M. , Saullo Jennifer L. 
Published: April 2018

AbstractBackgroundNocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited.MethodsWe performed a retrospective chart review of all patients at Duke University Hospital with a history of solid organ transplant (SOT) or hematopoietic cell transplant (HCT) and at least one positive culture for Nocardia between 1996 and 2013. Our aim was to describe the epidemiology and outcomes of Nocardia infections in the transplanted host.ResultsDuring the 18‐year study period, 51 patients (14 HCT and 37 SOT recipients) had Nocardia infection. Nocardia incidence was stable during the study period in all populations except heart transplants, whose incidence declined. Infection occurred earlier in the HCT group than the SOT group (median time to diagnosis of 153 and 370 days, respectively). In both groups, the most common site involved was the lung. Outcomes were overall poor, especially in the HCT group with a cure rate of 29%. Heart transplant recipients had significantly better overall survival (P < .05) than other patients. Trimethoprim‐sulfamethoxazole (TMP‐SMX) prophylaxis did not provide complete protection from Nocardia infections, nor did it appear to select for resistant Nocardia isolates.ConclusionsInfections with Nocardia are typically a late post‐transplant complication. The use of TMP‐SMX prophylaxis was not associated with TMP‐SMX‐resistant Nocardia. Overall outcomes remain poor.