bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moxifloxacin/Gatifloxacin‐1,2,3‐triazole‐isatin Hybrids with Hydrogen‐Bond Donor and Their In Vitro Anticancer Activity
Authors: Chen Rongxing , Zhang Hao , Ma Tianwei , Xue Huarui , Miao Zhong , Chen Liyan , Shi Xiangkui 
Published: August 2019

A series of novel moxifloxacin/gatifloxacin‐1,2,3‐triazole‐isatin hybrids (8a–i) were designed, synthesized, and screened for their in vitro anticancer activity in this paper. All of the synthesized hybrids were active against A549 and HepG2 cancer cell lines, whereas the parent drugs moxifloxacin and gatifloxacin were devoid of activity. Among them, hybrid 8i (IC50: 41.1–98.3 μM) showed considerable activity against A549, HepG2, and MCF‐7 cancer cell lines, and it was no inferior to Vorinostat (IC50: 64.32 to >100 μM) against the three cancer cell lines. Thus, this kind of hybrids has potentiality for discovery of new anticancer candidates for clinical deployment in the control and eradication of cancers.
Institutional Support and Sustainability of Microcredit Programmes in Developing Countries: The Case of Venezuela
Authors: García‐Rodríguez Francisco J. , Suárez‐Mancha Maribel , Castilla‐Gutiérrez Carlos , García‐Rodríguez José León 
Published: August 2019

AbstractThis paper analyses a microcredit programme that was developed in a rural area of Venezuela, a standard‐bearer for left‐wing movements in Latin America, after significant initial support from the public sector disappeared. The findings indicate high levels of stability for the microfinance organisations: the number of shares, the volume of savings and the amount of the loans granted had all increased, with low levels of loan default. However, significant organisational deterioration and a reduction in the social and environmental impact in the community were also observed, aspects that point to a need to rethink institutional support in these areas. © 2019 John Wiley & Sons, Ltd.
Dual‐frequency MR elastography to differentiate between inflammation and fibrosis of the liver: Comparison with histopathology
Authors: Sofue Keitaro , Onoda Minori , Tsurusaki Masakatsu , Morimoto Daisuke , Yada Norihisa , Kudo Masatoshi , Murakami Takamichi 
Published: August 2019

BackgroundDifferentiation between inflammation and fibrosis is an important clinical distinction in patients with chronic liver disease, which has been difficult so far with MR elastography.PurposeTo investigate whether dual‐frequency MR elastography can estimate necroinflammation of the liver and improve diagnostic performance for the staging of liver fibrosis.Study TypeRetrospective.SubjectsIn all, 30 patients (14 males, 16 females) with chronic liver disease.Field Strength/Sequence1.5T/dual‐frequency MR elastography at 60‐Hz and 80‐Hz vibration frequencies. [Correction added on November 12, 2019, after first online publication: The field strength in the preceding sentence was corrected.]AssessmentNecroinflammation activity and fibrosis were assessed using the METAVIR scoring system. Stiffness values at 60‐Hz (G60‐Hz) and 80‐Hz (G80‐Hz) were obtained with an MR elastogram. The difference value between G80‐Hz and G60‐Hz (ΔG) was calculated. Four values (G60‐Hz, G80‐Hz, G60‐Hz – ΔG, and G80‐Hz + ΔG) were generated to estimate necroinflammation and fibrosis.Statistical TestsThe ΔG were correlated with necroinflammation activity grade and fibrosis stage using Spearman's rank correlation. Diagnostic performance of the four values for necroinflammation activity grade and fibrous stage was assessed by using area under the receiver operating characteristic curve (AUC).ResultsThe mean value of G80‐Hz (6.23 ± 3.67 kPa) was significantly higher than that of G60‐Hz (5.27 ± 3.14 kPa) (P < 0.0001). The ΔG demonstrated a strong correlation with necroinflammation grade (ρ = 0.625, P < 0.001) and no correlation with fibrosis stage (ρ = 0.306, P = 0.113). The AUC of the G80‐Hz and G80‐Hz + ΔG showed higher accuracy for necroinflammation, and optimal cutoff values yielded better discrimination of ≥A1, ≥A2, and = A3. The AUC demonstrated that all the generated values had high diagnostic performance (≥0.87 for all) for fibrosis.Data ConclusionDual‐frequency MR elastography shows potential in estimating necroinflammation of the liver and may improve diagnostic performance for staging liver fibrosis.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2020;51:1053–1064.
Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI‐1/Serpine1) Null Mice
Authors: Freeberg Margaret A.T. , Easa Anas , Lillis Jacquelyn A. , Benoit Danielle S.W. , van Wijnen Andre J. , Awad Hani A. 
Published: August 2019

ABSTRACTInjuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Plasminogen activator inhibitor 1 (PAI‐1/SERPINE1), a master suppressor of fibrinolysis and protease activity, is associated with adhesions. Here, we used next‐generation RNA sequencing (RNA‐Seq) to assess genome‐wide differences in messenger RNA expression due to PAI‐1 deficiency after zone II flexor tendon injury. We used the ingenuity pathway analysis to characterize molecular pathways and biological drivers associated with differentially expressed genes (DEG). Analysis of hundreds of overlapping and DEG in PAI‐1 knockout (KO) and wild‐type mice (C57Bl/6J) during tendon healing revealed common and distinct biological processes. Pathway analysis identified cell proliferation, survival, and senescence, as well as chronic inflammation as potential drivers of fibrotic healing and adhesions in injured tendons. Importantly, we identified the activation of PTEN signaling and the inhibition of FOXO1‐associated biological processes as unique transcriptional signatures of the healing tendon in the PAI‐1/Serpine1 KO mice. Further, transcriptomic differences due to the genetic deletion of PAI‐1 were mechanistically linked to PI3K/Akt/mTOR, PKC, and MAPK signaling cascades. These transcriptional observations provide novel insights into the biological roles of PAI‐1 in tendon healing and could identify therapeutic targets to achieve scar‐free regenerative healing of tendons. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:43–58, 2020
Sources of tourism growth in Mainland China: An extended data envelopment analysis‐based decomposition analysis
Authors: Zha Jianping , Zhu Ying , He Dongqin , Tan Ting , Yang Xiaojie 
Published: August 2019

AbstractUnderstanding the driving factors of tourism growth provides insights into tourism growth patterns and can inform tourism policymaking. This paper develops a novel data envelopment analysis (DEA)‐based decomposition approach, a combined use of DEA, meta‐frontier theory, and polar decomposition method, for decomposing tourism growth into seven components, that is, technological efficiency, technology gap effect, technological progress, labour input effect, capital input effect, tourism resource endowment effect, and environmental overload effect. Subsequently, an empirical study has been undertaken for Mainland China during the period of 2005–2015. The results reveal that factor inputs contribute more to China's tourism growth than total factor productivity. The gap between the contributions of factor inputs and total productivity to tourism growth has gradually been narrowing over time. Further decomposition shows that the above seven sources of tourism growth show distinct spatial characteristics. Finally, according to the estimation results, this paper formulates targeted strategies to promote sustainable tourism growth in Mainland China.
The Hyperechoic Appearance of the Deltoid Muscle on Shoulder Ultrasound Imaging as a Predictor of Diabetes and Prediabetes
Authors: Soliman Steven B. , Rosen Kelli A. , Williams Paul C. , Spicer Paul J. , Williams L. Keoki , Rao Sudhaker D. , van Holsbeeck Marnix T. 
Published: August 2019

ObjectivesTo evaluate whether the ultrasound appearance of the deltoid muscle in diabetic patients differs from that in obese nondiabetic patients.MethodsUltrasound images of the deltoid muscle from 137 type 2 diabetic patients (including 13 prediabetic patients) and 49 obese nondiabetic patients were blindly reviewed by 2 musculoskeletal radiologists, and by a third when arbitration was needed, to determine whether the appearance was “normal,” “suspected diabetes,” or “definite diabetes.” Age, sex, race, body mass index (BMI), insulin use, and hemoglobin A1c were analyzed. This retrospective study included patients presenting between October 2005 and November 2017. Statistical analyses included a 2‐sided sample t test or Wilcoxon rank sum test and a χ2 or Fisher exact test. Statistical significance was defined as P < .05.ResultsThe type 2 diabetic patients included 98 women and 39 men aged 29 to 92 years, and the nondiabetic patients included 19 women and 30 men aged 18 to 75 years. A consensus diagnosis of definite diabetes by the musculoskeletal radiologists based on a hyperechoic deltoid was a powerful predictor of diabetes, with a positive predictive value of 89%. A hyperechoic deltoid was also a powerful predictor of prediabetes. Of the 13 prediabetic patients, all had the same hyperechoic appearance of the diabetic deltoid, regardless of BMI. Although obese diabetic patients more often had a diagnosis of definite diabetes, the BMI alone could not explain the increased echogenicity, as obese nondiabetic patients’ deltoid muscles did not appear as hyperechoic and were correctly categorized as not having definite diabetes with 82% specificity.ConclusionsThe characteristic hyperechoic deltoid appearance is a strong predictor of both diabetes and prediabetes and differs from that of obese nondiabetic patients.
Cadmium, obesity, and education, and the 10‐year incidence of hearing impairment: The beaver dam offspring study
Authors: Dalton Dayna S. , Schubert Carla R. , Pinto Alex , Fischer Mary E. , Huang Guan‐Hua , Klein Barbara E. K. , Klein Ronald , Pankow James S. , Paulsen Adam J. , Tsai Michael Y. , Tweed Ted S. , Cruickshanks Karen J. 
Published: August 2019

Objectives/HypothesisTo determine the 10‐year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle‐aged cohort followed for 10 years.Study DesignProspective cohort study.MethodsHearing thresholds were measured at baseline (2005–2008) and 5‐ (2010–2013) and 10‐year (2015–2017) follow‐up examinations. HI was defined as a pure‐tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow‐up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium.ResultsParticipants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10‐year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7–19.2) and was twice as likely in men (24.4%, 95% CI: 21.5–27.7) than in women (12.2%, 95% CI: 10.3–14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38–1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91–3.18), less than a college education (HR = 1.35, 95% CI: 1.02–1.79), body mass index (HR = 1.03, 95% CI: 1.01–1.05, per kg/m2), and higher cadmium levels (HR = 1.42, 95% CI: 1.05–1.92, quintile 5 vs. quintiles 1–4) were associated with the 10‐year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10‐year incidence of HI.ConclusionsIn addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age‐related HI is a multifactorial preventable disorder.Level of Evidence2b Laryngoscope, 130:1396–1401, 2020
A two‐stage fuzzy approach for Industry 4.0 project portfolio selection within criteria and project interdependencies context
Authors: Demircan Keskin Fatma 
Published: August 2019

AbstractIndustry 4.0, the new vision of our age has forced companies to transform their processes. In the process of transition to Industry 4.0, one of the most crucial success factors is to select the project portfolio that best fits their objectives. The uncertainty included in the projects, the interproject priority, and various interdependence relations, interactions between project evaluation criteria, decision makers with different perspectives, and preferences make Industry 4.0 project portfolio selection decision considerably complicated. In this study, a two‐stage fuzzy approach is proposed to address this complex problem. In the first stage of the approach, the main criteria and subcriteria to be used in evaluating the Industry 4.0 projects have been determined based on the literature review and expert opinions. Following this, a network structure representing outer and inner dependencies has been formed, and the priority weights of the criteria have been obtained by taking into consideration these dependencies. Then, each of the project alternatives has been evaluated under subcriteria, and desirability indexes of project alternatives have been calculated. Fuzzy analytic network process has been applied in this stage. In the second stage, fuzzy multi‐objective nonlinear programming has been used to select a project portfolio. In the application of the first stage of the proposed methodology, experts from three firms, which have made significant progress in the Industry 4.0 implementation process, are the decision makers. In the application of the second stage, hypothetically created project alternatives and their dataset have been used.
Is Good Fish Culture Management Harming Recovery Efforts in Aquaculture-Assisted Fisheries?
Authors: Tave Douglas , Hutson Alison M 
Published: August 2019

Abstract
To make conservation aquaculture successful, a paradigm shift is needed in what is considered good hatchery management as defined by production aquaculture as well as in the metrics that are used to evaluate hatchery success. In production aquaculture, managers strive to maintain exceptional environmental conditions to maximize yield, the number of fish produced, and survival. However, this type of aquaculture management could decrease the likelihood of success of imperiled species recovery programs due to domestication and epigenetics. Consequently, good management practices in conservation aquaculture should produce conditions that resemble the environment where the fish will be stocked in order to minimize domestication and epigenetic problems that will lower the fitness of wild stocks following augmentation. Changes in what are considered good culture conditions require a new set of hatchery evaluation metrics. The key metric that needs to be altered is the survival rate. Survival is the keystone metric because it determines other metrics such as the number produced, yield, and profits. High survival rates influence domestication, which adversely affects post-augmentation survival and the fitness of the wild stock. Consequently, lower hatchery survival rates produced by selective pressures in conservation aquaculture are needed to improve success in imperiled species recovery programs. We propose that survival be 10–25% to improve success. Our proposed evaluation metrics for conservation aquaculture are to produce “wild” fish and not lower the fitness of the wild population. We recognize that these recommendations are controversial, but a major goal of this paper is to start a discussion about the most appropriate way to evaluate this type of aquaculture so that recovery efforts for imperiled species can be improved.
Cardiovascular safety of macrolide and fluoroquinolone antibiotics: An analysis of the WHO database of adverse drug reactions
Authors: Bonaldo Giulia , Andriani Luisa Anna , D'Annibali Ottavio , Motola Domenico , Vaccheri Alberto 
Published: August 2019

AbstractIntroductionThe cardiovascular safety profile of macrolides and fluoroquinolones has been widely discussed. The aim of the present study is to provide the contribution of real‐world data onto the ongoing discussion about cardiovascular toxicity of both macrolides and fluoroquinolones.MethodsReports of adverse drug reactions (ADRs) were retrieved from VigiBase. Macrolides and fluoroquinolones were compared with amoxicillin by using the reporting odds ratio (ROR) as a measure of disproportionality. Macrolides were then compared with fluoroquinolones.ResultsOverall, 6810 reports of ADRs were retrieved: 62% of them were serious and 35% concerned female. Macrolides were more frequently associated with “atrial fibrillation” (ROR = 1.26, CI 1.02‐1.57) and “ventricular fibrillation” ROR = 2.60, CI 1.92‐3.54) than fluoroquinolones. Antimicrobials more frequently reported for “cardiac disorder” were azithromycin (375 reports) and clarithromycin (302) for macrolides and levofloxacin (470) and moxifloxacin (391) for fluoroquinolones.ConclusionOur data highlighted that macrolides and fluoroquinolones may influence cardiac rhythm and suggest caution in the prescribing of these drugs to patients with hidden cardiovascular risk factors. Although these ADRs seem to be not common, they have a notable impact in clinical practice because of the huge number of the exposed subjects.
The role of polysomnography in tracheostomy decannulation of children with bronchopulmonary dysplasia
Authors: Quinlan Courtney , Piccione Joseph , Kim Ji‐Young , Beck Suzanne E. , Brooks Lee , Chandy‐Patel Rosemary , Escobar Emma , Afolabi‐Brown Olufunke 
Published: August 2019

AbstractBackgroundPatients with bronchopulmonary dysplasia (BPD) may require tracheostomy for long‐term mechanical ventilation. Polysomnography (PSG) may predict successful decannulation in children, however it is unclear how this success compares with children without a PSG. To better evaluate this role, we compared decannulation outcomes between tracheostomy‐dependent children with BPD who underwent PSG before decannulation to those who did not.MethodsThis is a retrospective cohort study between 1 January 2007 and 1 June 2017 of tracheostomy‐dependent children with BPD who were clinically considered for decannulation. Patient demographics, PSG results, and medical comorbidities were abstracted from medical records and compared between groups. Decannulation outcomes were compared between children with BPD who underwent PSG before decannulation and those who did not.ResultsOne hundred twenty‐five patients with BPD were considered for tracheostomy decannulation. Forty‐six (37%) had a pre‐decannulation PSG while 79 (63%) did not. Nineteen (41%) patients did not undergo decannulation within 6 months of the PSG. One (3%) patient with pre‐decannulation PSG failed decannulation. Four (5%) patients without pre‐decannulation PSG failed decannulation. Nineteen patients with PSG and no decannulation had significantly higher obstructive apnea‐hypopnea index (OAHI) (13.62 vs 2.68 events per hour, P = 0.004), higher end‐tidal CO
2 max (52.84 vs 48.03 mm Hg, P = 0.035), and were older at PSG (median age, 6.04 vs 4.04 years, P = 0.008).ConclusionsWhile successful decannulation can be achieved without a PSG in some patients, PSG is a valuable tool to identify BPD patients undergoing clinical evaluation for decannulation who would benefit from treatment of OSA before decannulation.
Controlled evaluation of a transition clinic for Dutch young people with cystic fibrosis
Authors: Peeters Mariëlle A. C. , Sattoe Jane N. T. , van Staa AnneLoes , Versteeg Simone E. , Heeres Inge , Rutjes Niels W. , Janssens Hettie M. 
Published: August 2019

AbstractBackgroundTransition clinics (TCs) are advocated as best practice to support young people with cystic fibrosis (CF) during transition to adulthood and adult care. We aimed to research the functioning of a TC for young people with CF compared with direct hand‐over care and to evaluate whether those treated at the TC have better transfer experiences and outcomes compared with the control group.MethodsMixed‐methods retrospective controlled design, including interviews with professionals, observations of clinics, chart reviews (at four measurement moments), and patient surveys. Qualitative data analysis focused on organization and daily routines, and barriers and facilitators experienced. Young people's transfer experiences, self‐management, health care use, and clinical outcomes were assessed quantitatively.ResultsThe most notable feature distinguishing the TC and direct hand‐over care comprised joint consultations between pediatric and adult care professionals in the former. A transition coordinator was considered essential for the success of the TC. The main barriers were lack of time, planning, and reimbursement issues. Young people treated at the TC tended to have better transfer experiences and were more satisfied. They reported significantly more trust in their adult care professionals. Their self‐management‐related outcomes were less favorable.ConclusionsThe TC had several perceived benefits and showed positive trends in transfer experiences and satisfaction, but no differences in health‐related outcomes. Structured preparation of young people, joint consultations with pediatric and adult care professionals, and better coordination were perceived as facilitating elements. Further improvement demands solutions for organizational and financial barriers, and better embedding of self‐management interventions in CF care.
Surfactant therapy in premature babies: SurE or InSurE
Authors: Jena Soumya R. , Bains Harmesh S. , Pandita Aakash , Verma Anup , Gupta Vishal , Kallem Venkat R. , Abdullah Mohammed , Kawdiya Apurva , on behalf of SURE group  
Published: August 2019

AbstractBackground: Preterm infants with respiratory distress syndrome (RDS) requiring surfactant therapy have been traditionally receiving surfactant by intubation surfactant and extubation technique (InSurE), which comprises of tracheal intubation, surfactant administration, and extubation. However, more recently noninvasive methods like least invasive surfactant therapy or minimally invasive surfactant therapy have been reported to be successful. These methods, avoid intubation thus minimize airway trauma and avoid barotrauma. The primary aim of this randomized trial was to compare the need for mechanical ventilation (MV) between the administration of surfactant via a thin catheter during spontaneous breathing and the InSurE technique.Methods: Preterm infant's ≤34 weeks with RDS requiring continuous positive airway pressure (CPAP) within 6 hours of life were prospectively randomized to receive early surfactant either by SurE (surfactant without endotracheal tube intubation) or InSurE technique. The need for MV within the first 72 hours and other related outcomes were analyzed between the two groups.Results: One hundred seventy‐five infants in each group were analyzed. The need for MV in the first 72 hours of life was significantly lower in the SurE group compared to the InSurE group (19% vs 40%, P < .01). Similarly, duration of oxygen therapy and hospital stay were significantly shorter in the SurE group. Furthermore, bronchopulmonary dysplasia (BPD) rate was significantly lower among the infants administered surfactant by the SurE technique.Conclusion: In preterm neonates with RDS who are stabilized on CPAP, the SurE technique for surfactant delivery results in the reduced need for MV and also may decrease the rate of BPD in some vulnerable subpopulations.