bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-Dimensional Proton Magnetic Resonance Spectroscopy versus J-Editing for GABA Quantification in Human Brain: Insights from a GABA-Aminotransferase Inhibitor Study
Authors: Prescot Andrew P. , Prisciandaro James J. , Miller Steven R. , Ingenito Gary , Kondo Douglas G. , Renshaw Perry F. 
Published: August 2018

AbstractMetabolite-specific, scalar spin-spin coupling constant (J)-editing 1H MRS methods have become gold-standard for measuring brain γ-amino butyric acid (GABA) levels in human brain. Localized, two-dimensional (2D) 1H MRS technology offers an attractive alternative as it significantly alleviates the problem of severe metabolite signal overlap associated with standard 1D MRS and retains spectroscopic information for all MRS-detectable species. However, for metabolites found at low concentration, a direct, in vivo, comprehensive methods comparison is challenging and has not been reported to date. Here, we document an assessment of comparability between 2D 1H MRS and J-editing methods for measuring GABA in human brain. This clinical study is unique in that it involved chronic administration a GABA-amino transferase (AT) inhibitor (CPP-115), which induces substantial increases in brain GABA concentration, with normalization after washout. We report a qualitative and quantitative comparison between these two measurement techniques. In general, GABA concentration changes detected using J-editing were closely mirrored by the 2D 1H MRS time courses. The data presented are particularly encouraging considering recent 2D 1H MRS methodological advances are continuing to improve temporal resolution and spatial coverage for achieving whole-brain, multi-metabolite mapping.
Plasma metabolomic profiles differ at the time of artificial insemination based on pregnancy outcome, in Bos taurus beef heifers
Authors: Phillips Kaitlyn M. , Read Casey C. , Kriese-Anderson Lisa A. , Rodning Soren P. , Brandebourg Terry D. , Biase Fernando H. , Marks M. Landon , Elmore Joshua B. , Stanford M. Kent , Dyce Paul W. 
Published: August 2018

AbstractInfertility remains the most prevalent reason for cattle being removed from production environments. We utilized metabolomic profiling to identify metabolites in the blood plasma that may be useful in identifying infertile heifers at the time of artificial insemination (AI). Prior to AI, phenotypic parameters including body condition, weight, and reproductive organ measurements were collected. These were determined not effective at differentiating between fertile and infertile heifers. Analysis of the resulting metabolomic profiles revealed 15 metabolites at significantly different levels (T-test P ≤ 0.05), with seven metabolites having a greater than 2-fold difference (T-test P ≤ 0.05, fold change ≥2, ROC-AUC ≥ 0.80) between infertile and fertile heifers. We further characterized the utility of using the levels of these metabolites in the blood plasma to discriminate between fertile and infertile heifers. Finally, we investigated the potential role inflammation may play by comparing the expression of inflammatory cytokines in the white blood cells of infertile heifers to that of fertile heifers. We found significantly higher expression in infertile heifers of the proinflammatory markers tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), and the C-X-C motif chemokine 5 (CXCL5). Our work offers potentially valuable information regarding the diagnosis of fertility problems in heifers undergoing AI.
Dengue virus infection changes Aedes aegypti oviposition olfactory preferences
Authors: Gaburro Julie , Paradkar Prasad N. , Klein Melissa , Bhatti Asim , Nahavandi Saeid , Duchemin Jean-Bernard 
Published: August 2018

AbstractAedes aegyptimosquitoes, main vectors for numerous flaviviruses, have olfactory preferences and are capable of olfactory learning especially when seeking their required environmental conditions to lay their eggs. In this study, we showed that semiochemical conditions duringAedes aegyptilarval rearing affected future female choice for oviposition: water-reared mosquitoes preferred to lay eggs in water or p-cresol containers, while skatole reared mosquitoes preferred skatole sites. Using two independent behavioural assays, we showed that this skatole preference was lost in mosquitoes infected with dengue virus. Viral RNA was extracted from infected female mosquito heads, and an increase of virus load was detected from 3 to 10 days post infection, indicating replication in the insect head and possibly in the central nervous system. Expression of selected genes, potentially implied in olfactory learning processes, were also altered during dengue infection. Based on these results, we hypothesise that dengue virus infection alters gene expression in the mosquito’s head and is associated with a loss of olfactory preferences, possibly modifying oviposition site choice of female mosquitoes.
The orientation of galaxy pairs with filamentary structures: dependence on morphology
Authors: Mesa Valeria , Duplancic Fernanda , Alonso Sol , Muñoz Jofré Maria Rosa , Coldwell Georgina , Lambas Diego G. 
Published: August 2018

Aims. With the aim of performing an analysis of the orientations of galaxy pair systems with respect to the underlying large-scale structure, we study the alignment between the axis connecting the pair galaxies and the host cosmic filament where the pair resides. In addition, we analyze the dependence of the amplitude of the alignment on the morphology of pair members as well as filament properties.
Methods. We build a galaxy pair catalog requiring rp < 100 h−1 kpc and ΔV < 500 km s−1 within redshift z < 0.1 from the Sloan Digital Sky Survey (SDSS). We divided the galaxy pair catalog taking into account the morphological classification by defining three pair categories composed by elliptical–elliptical (E–E), elliptical–spiral (E–S) and spiral–spiral (S–S) galaxies. We use a previously defined catalog of filaments obtained from SDSS and we select pairs located closer than 1 h−1 Mpc to the filament spine, which are considered as members of filaments. For these pairs, we calculate the relative angle between the axis connecting each galaxy, and the direction defined by the spine of the parent filament.
Results. We find a statistically significant alignment signal between the pair axes and the spine of the host filaments consistent with a relative excess of ∼15% aligned pairs. We obtain that pairs composed by elliptical galaxies exhibit a stronger alignment, showing a higher alignment signal for pairs closer than 200 h−1 kpc to the filament spine. In addition, we find that the aligned pairs are associated with luminous host filaments populated with a high fraction of elliptical galaxies. The findings of this work show that large-scale structures play a fundamental role in driving galactic anisotropic accretion as induced by galaxy pairs exhibiting a preferred alignment along the filament direction.
Adulte Lumbalskoliose – ändert sich die Therapie mit zunehmendem Alter?
Authors: Quante Markus 
Published: August 2018

ZusammenfassungPatienten mit adulter lumbaler Skoliose werden meist in der 2. Lebenshälfte zunehmend therapiebedürftig. Neben konservativen und interventionellen Maßnahmen können mitunter sehr umfangreiche operative Therapien indiziert werden. Diese Arbeit befasst sich mit den Möglichkeiten, die Therapiestratifizierung auch altersabhängig zu betreiben. Hierzu werden 3 biologische Altersgruppen (jung, mittel, alt) definiert und in therapeutischer Hinsicht gegeneinander abgegrenzt.
A novel device for intracolonoscopy cleansing of inadequately prepared colonoscopy patients: a feasibility study
Authors: van Keulen Kelly , Neumann Helmut , Schattenberg Jörn , van Esch Aura , Kievit Wietske , Spaander Manon , Siersema Peter 
Published: August 2018

Abstract
Background The importance of high quality preprocedural bowel preparation is widely acknowledged, but suboptimal bowel cleansing still occurs in up to 20 % of all colonoscopy patients. The aim of this study was to evaluate the performance of a novel intraprocedural cleaning device for cleaning poorly prepared colons.
Methods This multicenter feasibility study included patients aged 18 – 75 years who were referred for colonoscopy. Intraprocedural cleaning was performed in patients after a limited preprocedural bowel preparation regimen (2 days of dietary restrictions and 2 × 10 mg bisacodyl). The primary outcome was the proportion of adequately prepared patients (Boston Bowel Preparation scale [BBPS] ≥ 2 in each segment) before and after segmental washing with the new device. Secondary outcomes included: cecal intubation rate, procedure time, system usability, patient satisfaction, and safety.
Results 47 patients (42.6 % male), with a median age of 61 years (interquartile range [IQR] 46 – 67 years), were included at three clinical sites. Cecal intubation was achieved in 46/47 patients (97.9 %). The cleaning device significantly improved the proportion of patients with adequate bowel cleansing (from 19.1 % to 97.9 %; P < 0.001) and median BBPS score (from 3.0 [IQR 0.0 – 5.0] to 9.0 [IQR 8.0 – 9.0]). Median cecal intubation time and total procedure time were 16.5 minutes (IQR 9.0−28.3) and 34.0 minutes (IQR 25.0 – 42.8), respectively. Physicians were satisfied with the ease of use of the device and it was well tolerated by patients. No severe adverse events occurred during the study period.
Conclusions This feasibility study suggests that the intraprocedural cleaning device appears to be safe and effective in cleaning poorly prepared colons to an adequate level, allowing a thorough colorectal examination.
Rescue Adjuvant Vaginal Progesterone May Improve Outcomes in Cervical Cerclage Failure
Authors: Roman Alina , Da Silva Costa Fabricio , Araujo Júnior Edward , Sheehan Penelope 
Published: August 2018

Abstract
Introduction Aim of the study was to evaluate the effect of rescue adjuvant vaginal progesterone in women with ongoing, transvaginal ultrasound (TVUS)-confirmed cervical shortening despite cervical cerclage.
Materials and Methods A retrospective case control study was performed of women undergoing cervical surveillance following either history- or ultrasound-indicated cervical cerclage. We compared women managed with cervical cerclage and vaginal progesterone to women managed with cervical cerclage alone. Women with a singleton pregnancy who underwent cervical cerclage were identified from a database. Data on the concurrent use of vaginal progesterone, cervical length measurements, interventions and birth outcomes were collected from patient notes and clinical pathology notes. Patients from each intervention group were matched, based on exact shortest cervical length measurements obtained during surveillance and age of gestation when the measurement was obtained.
Results 66 women were matched and included in the study, based on exact shortest cervical length measurements. Each group had an identical mean shortest cervical length of 12.09 mm. The outcomes of 33 women who received both cervical cerclage and vaginal progesterone were compared to the outcomes of 33 women who were treated with cervical cerclage alone. The administration of vaginal progesterone to women with ongoing cervical shortening despite cervical cerclage was found to significantly prolong the pregnancy (36.36 weeks vs. 32.63 weeks; p = 0.0036) compared to women treated with cerclage alone. This use of rescue adjuvant vaginal progesterone was also associated with higher birth weights (2829 g vs. 2134 g; p = 0.0065) compared to women who had cervical cerclage alone; however, there was no difference in Apgar scores, composite neonatal morbidity or neonatal intensive care admission.
Conclusion Women with cervical shortening despite the presence of cervical cerclage may benefit from further TVUS cervical length surveillance and the administration of vaginal progesterone if further cervical shortening occurs. Despite both groups having clinically significant shortened cervical lengths and cervical cerclage in situ, adjunct vaginal progesterone treatment resulted in older gestational age at birth and higher birth weight. Further investigation and confirmation of this finding in a larger prospective trial is warranted to explore this potential benefit for the management of preterm birth in future.
Foetal Morbidity Depending on the Day and Time of Delivery
Authors: von Ehr Julia , Wiebking Nina , Kundu Sudip , von Kaisenberg Constantin , Hillemanns Peter , Soergel Philipp 
Published: August 2018

Abstract
Introduction It is known that perinatal mortality is increased with births at night and at the weekend. The aim of the study was to investigate whether there is also an association between the time of delivery (weekday, night, weekend) and perinatal morbidity.
Material and Methods All births at Hannover Medical College between 2000 and 2014 were included in a retrospective data analysis. Multiple births, primary sections, severe foetal malformations and intrauterine deaths were not included. A 5-minute Apgar score ≤ 5 and cord arterial pH < 7.10 were defined as perinatal morbidity. Besides the time of delivery, different variables that are regarded as risk factors for increased perinatal morbidity were studied. Univariate logistical regression analysis was performed, followed by multivariate analysis.
Results 18 394 deliveries were included in the study. Pathological prepartum Doppler, medical induction of labour and delivery at night and/or at the weekend significantly increased the probability of an Apgar score ≤ 5 after 5 minutes. The probability that a child will have cord arterial pH < 7.1 post partum is significantly increased with a BMI > 25 before pregnancy, primiparity, medical induction of labour, peripartum administration of oxytocic agents, when the delivery took place at night and weekend combined, but also when the delivery took place at night or at the weekend/on a public holiday. Multivariate regression analysis showed that a time of delivery at night and/or at the weekend or on a public holiday is not a prognostic factor for a 5-minute Apgar score ≤ 5 (p = 0.2377) but is a prognostic factor for cord arterial pH < 7.1 (p = 0.0252).
Conclusion The time of delivery at night or at the weekend/on a public holiday increases the risk for cord arterial pH < 7.1 by ~ 30% compared with delivery on a weekday. However, the time of delivery at night or at the weekend/on a public holiday does not increase the risk for the baby of having a 5-minute Apgar score ≤ 5.
Neoadjuvant Therapy of Cervical Carcinoma with the Angiogenesis Inhibitor Bevacizumab: a Single-Centre Analysis
Authors: Junker Philip , Puppe Julian , Thangarajah Fabinshy , Domröse Christian , Cepic Angela , Morgenstern Bernd , Ratiu Dominik , Hellmich Martin , Mallmann Peter , Wirtz Marina 
Published: August 2018

Abstract
Introduction Cervical cancer is the fourth most frequent cancer in women worldwide. Addition of the VEGF antibody bevacizumab in combination with platinum-containing chemotherapy achieved an improvement in overall survival in advanced cervical cancer. To date there are no data on neoadjuvant use of bevacizumab. We therefore studied the benefit of neoadjuvant combined therapy with bevacizumab in a group of cervical cancer patients.
Patients and Methods This retrospective cohort study analysed 14 patients with cervical cancer FIGO stages 1b1 to IV who received neoadjuvant platinum-containing chemotherapy in combination with bevacizumab. The comparative cohort consisted of 16 patients who were treated with neoadjuvant platinum-containing chemotherapy alone. The response rates were determined by means of preoperative clinical examination, diagnostic imaging (RECIST), changes in tumour markers (SCC) and by histopathology.
Results A clinical response was found in 93.8% (n = 15) of patients after bevacizumab-free therapy and in 100% (n = 14) of the patients who were treated with bevacizumab in addition. Combined therapy with bevacizumab led to a higher rate of clinical complete remission (42.9 vs. 12.5%; p = 0.072) and significantly improved the reduction in tumour size (Δ longest diameter: 3.7 vs. 2.5 cm; p = 0.025). Downgrading was observed in 100% of all patients treated with bevacizumab compared with 75% in the control arm. The rate of pathological complete remission (pCR) was not altered significantly (28.6% [n = 4] vs. 37.5% [n = 6]; p = 0.460).
Discussion Overall, combined therapy with bevacizumab led to a better clinical response. Operability was therefore improved more often. Because of the small patient cohort, larger prospective studies are necessary to validate the effect of neoadjuvant combined therapy with bevacizumab.
Communication in The Clinical Routine of Neonatologists
Authors: Börner Nele , Mache Stefanie , Scutaru Cristian , Metze Boris , Bührer Christoph 
Published: August 2018

Abstract
Introduction Communication is essential to clinical routine, especially in NICUs with their vulnerable patients and the special team caring for them. Communication breakdowns and resulting treatment errors are described in the literature. The aim of this study is to provide an initial quantitative assessment of medical communication in a NICU.
Methods For task analysis, 15 Level III-NICU physicians were accompanied for 60 days in early and late shifts; each physician completed the COPSOQ questionnaire. Recorded tasks were assigned to main task categories and subcategories.
Results A total of 550 h of main and 100 h of secondary tasks were recorded, on average 9 h daily. The most time-consuming main activity was “Communication” (3 h), followed by “Indirect care/Administration” (2 h) and “Direct patient care” (1.5 h). “Communication” mainly consisted of discussions with colleagues and during early shifts. At 2 min, communication with nursing personnel during rounds was especially low. Communication showed a negative correlation to physician job satisfaction.
Discussion This work shows the suspected high proportion of communication in a NICU, especially among physicians themselves. The effectiveness of this communication is not assessable. However, a low proportion of communication with nursing staff is noticeable and reflects the variabiliy in team communication. Improvement of communication is necessary through training on and the application of existing techniques for handoffs and rounds.
Between Access and Privacy: Challenges in Sharing Health Data
Authors: Malin Bradley , Goodman Kenneth ,   Section Editors for the IMIA Yearbook Special Section
Published: August 2018

Objective: To summarize notable research contributions published in 2017 on data sharing and privacy issues in medical informatics.
Methods: An extensive search of PubMed/Medline, Web of Science, ACM Digital Library, IEEE Xplore, and AAAI Digital Library was conducted to uncover the scientific contributions published in 2017 that addressed issues of biomedical data sharing, with a focus on data access and privacy. The selection process was based on three steps: (i) a selection of candidate best papers, (ii) the review of the candidate best papers by a team of international experts with respect to six predefined criteria, and (iii) the selection of the best papers by the editorial board of the Yearbook.
Results: Five best papers were selected. They cover the lifecycle of biomedical data collection, use, and sharing. The papers introduce 1) consenting strategies for emerging environments, 2) software for searching and retrieving datasets in organizationally distributed environments, 3) approaches to measure the privacy risks of sharing new data increasingly utilized in research and the clinical setting (e.g., genomic), 4) new cryptographic techniques for querying clinical data for cohort discovery, and 5) novel game theoretic strategies for publishing summary information about genome-phenome studies that balance the utility of the data with potential privacy risks to the participants of such studies.
Conclusion: The papers illustrated that there is no one-size-fitsall solution to privacy while working with biomedical data. At the same time, the papers show that there are opportunities for leveraging newly emerging technologies to enable data use while minimizing privacy risks.
Contributions from the 2017 Literature on Clinical Decision Support
Authors: Koutkias V. , Bouaud J. ,   Section Editors for the IMIA Yearbook Section on Decision Support
Published: August 2018

Objectives: To summarize recent research and select the best papers published in 2017 in the field of computerized clinical decision support for the Decision Support section of the International Medical Informatics Association (IMIA) yearbook.
Methods: A literature review was performed by searching two bibliographic databases for papers referring to clinical decision support systems (CDSSs). The aim was to identify a list of candidate best papers from the retrieved bibliographic records, which were then peer-reviewed by external reviewers. A consensus meeting of the IMIA editorial team finally selected the best papers on the basis of all reviews and the section editors' evaluation.
Results: Among the 1,194 retrieved papers, the entire review process resulted in the selection of four best papers. The first paper studies the impact of recency and of longitudinal extent of electronic health record (EHR) datasets used to train a data-driven predictive model of inpatient admission orders. The second paper presents a decision support tool for surgical team selection, relying on the history of surgical team members and the specific characteristics of the patient. The third paper compares three commercial drug-drug interaction knowledge bases, particularly against a reference list of highly-significant known interactions. The fourth paper focuses on supporting the diagnosis of postoperative delirium using an adaptation of the “anchor and learn” framework, which was applied in unstructured texts contained in EHRs.
Conclusions: The conducted review illustrated also this year that research in the field of CDSS is very active. Of note is the increase in publications concerning data-driven CDSSs, as revealed by the review process and also reflected by the four papers that have been selected. This trend is in line with the current attention that “Big Data” and data-driven artificial intelligence have gained in the domain of health and CDSSs in particular.