bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Unfocused Extracorporeal Shock Wave Therapy on Bone Defect Healing in Diabetics
Authors: Özkan Enes , Bereket Mehmet Cihan , Önger Mehmet Emin , Polat Ahmet Veysel 
Published: February 2018

Aim:
The purpose of this study was to evaluate the effect of the unfocused extracorporeal shock wave therapy (ESWT) on healing of mandible ramus defects in diabetic rats.

Material and method:
Forty male Wistar albino rats were used in the experiment. All animals were randomly divided into 2 main groups, nondiabetic and diabetic. Critical-sized defects were created on ramus in all rats. ESWT was performed to half of rats in each group at 3 sessions after surgery. Animals were euthanized at either fourth or eighth week. Stereological and radiologic examination was performed. Data were statistically analyzed by one-way variance analysis and Tukey post-hoc test.

Results:
Hounsfield Unit values were higher in D−E+ group than D−E− group in both 8-week and 4-week groups (P > 0.05). In both 4-week and 8-week diabetic groups, higher value was observed when compared with nondiabetic groups (P > 0.05). According to stereological results, in 4-week groups, there was a higher new bone, connective tissue, and neovascularization volume in D−E− group than D−E+ group and in D+E− group than D+E+ group. These results are similar for the 8-week groups except NV volume.

Conclusion:
It was found that ESWT application has no positive effect on the healing of critical-sized bone defects in nondiabetics whereas promising effects in diabetics were observed.
Improvements in Health-Related Quality of Life With Electroconvulsive Therapy
Authors: Giacobbe Peter , Rakita Uros , Penner-Goeke Kirsten , Feffer Kfir , Flint Alastair J. , Kennedy Sidney H. , Downar Jonathan 
Published: February 2018

Introduction
Although the antidepressant efficacy of ECT is well documented, patient-reported outcomes after this treatment are less well characterized. The aims of the current meta-analysis are to quantify the impact of an acute course of ECT on health-related quality of life (HRQoL) and to identify related moderators, specifically post-ECT depressive symptom remission and patient age.

Methods
We searched PubMed, PsycINFO, and Web of Science databases for randomized and nonrandomized studies that report on changes in HRQoL measures after an acute course of ECT. Only studies that used the Medical Outcomes Study Short Form 36 (SF-36) instrument were included. A random effects model using the Hedges' g effect size was used in calculating the pre-post ECT outcomes on all 8 SF-36 subscales and the SF-36 total scores including the physical and mental composite scores. Subgroup analyses were conducted using remission status and age as moderators.

Results
Four studies contributed to this analysis. Significant improvements across all subscales of the SF-36 were observed. Large and very large effect sizes were present for both the SF-36 physical component score (PCS) and mental health component score (MCS), with the change in MCS being statistically superior to the PCS (MCS, Hedges' g = 1.28; 95% confidence interval, 1.15–1.42; PCS, Hedges' g = 0.97; 95% confidence interval, 0.86–1.07). Medium, large, and very large effect sizes were observed for SF-36 subscales scores. Post-ECT depression remission status was related to HRQoL improvement, with statistically significant differences present between remitters and nonremitters for PCS, MCS, and most SF-36 subscale scores. No significant differences were observed in improvement in HRQoL with ECT based on patient age.

Conclusions
An acute course of ECT for depressive symptoms produces medium to very large effect size improvements in HRQoL across multiple components and subscales measured by the SF-36. The magnitude of the effects reported by ECT patients is greater than those that have been reported in other open-label studies of brain stimulation techniques. This study confirms that ECT plays a vital role in the treatment of the most severely ill patients with depressive disorders.
Strong and specific associations between cardiovascular risk factors and brain white matter micro- and macro-structure in health ageing
Authors: Fuhrmann Delia , Nesbitt David , Shafto Meredith , Rowe James B. , Price Darren , Gadie Andrew , Cam-CAN  , Kievit Rogier A. 
Published: February 2018

AbstractCardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle- and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure and heart rate) and white matter macrostructure (lesion volume and number), and microstructure (as measured by Diffusion Weighted Imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18 to 88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance. Lower diastolic blood pressure, higher systolic blood pressure and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure and heart rate affect white matter via separate mechanisms.
Evolution of male costs of copulation in sepsid flies (Diptera: Sepsidae)
Authors: Rohner Patrick T. , Shen Yoong Kai , Tuan Mindy J. M. , Meier Rudolf 
Published: February 2018

AbstractReproduction is well known to be costly for females, but longevity costs of copulations in males are still poorly understood. In particular, the effect of the number of copulations on male longevity is rarely considered. Work on black scavenger flies (Diptera: Sepsidae) showed contrasting results: in Saltella sphondylii the number of copulations is strongly negatively correlated with male longevity, whereas in Sepsis cynipsea mated males did not suffer from reduced longevity. Here we summarize the findings of several studies covering four additional species of sepsid flies from across the phylogenetic tree of sepsids to better understand the evolution of male reproductive costs in this clade. After accounting for the mating system differences between species, we find no evidence for longevity costs in Allosepsis sp., Sepsis fulgens and Themira superba, while in Saltella nigripes multiple copulations drastically reduced longevity. Mapping this trait onto the most current phylogenetic hypothesis for Sepsidae suggests that male cost in Saltella is derived while there is an absence of longevity costs for all other sepsids. We discuss the origin of this novel longevity cost in Saltella in the context of a change in their reproductive strategy, namely the evolution of high polygynandry coupled with unusually brief copulations.
An evolutionary-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity inHydra
Authors: Vogg Matthias C. , Beccari Leonardo , Iglesias Ollé Laura , Rampon Christine , Vriz Sophie , Perruchoud Chrystelle , Wenger Yvan , Galliot Brigitte 
Published: February 2018

AbstractTheHydrapolyp regenerates its head by transforming the gastric tissue below the wound into a head organizer made of two antagonistic cross-reacting components. The activator, previously characterized asWnt3, drives apical differentiation by acting locally and auto-catalytically. The uncharacterized inhibitor, produced under the control of the activator, prevents ectopic head formation. By crossing RNA-seq data obtained in aβ-catenin(RNAi) screen performed in planarians and a quantitative analysis of positional and temporal gene expression inHydra, we identified Sp5 as a transcription factor that fulfills the head inhibitor properties: a Wnt/β-catenin inducible expression, a graded apical-to-basal expression, a sustained up-regulation during head regeneration, a multi-headed phenotype when knocked-down, a repressing activity on Wnt3 expression. In mammalian cells,Hydraand zebrafish Sp5 repressWnt3promoter activity whileHydra Sp5also auto-activates its expression, possibly via β-catenin and/or Tcf/Lef1 interaction. This work identifies Sp5 as a novel potent feedback loop inhibitor of Wnt/β-catenin signaling across eumetazoans.
Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 inC. elegans
Authors: Kim Hyun-Min , Beese-Sims Sara E. , Colaiácovo Monica P. 
Published: February 2018

ABSTRACTThe histone demethylase LSD1 was originally discovered as removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1), and several studies suggest it plays roles in meiosis as well as epigenetic sterility given that in its absence there is evidence of a progressive accumulation of H3K4me2 through generations. In addition to transgenerational sterility, growing evidence for the importance of histone methylation in the regulation of DNA damage repair has attracted more attention to the field in recent years. However, we are still far from understanding the mechanisms by which histone methylation is involved in DNA damage repair and only a few studies have been focused on the roles of histone demethylases in germline maintenance. Here, we show that the histone demethylase LSD1/CeSPR-5 is interacting with the Fanconi Anemia (FA) protein FANCM/CeFNCM-1 based on biochemical, cytological and genetic analyses. LSD1/CeSPR-5 is required for replication stress-induced S-phase checkpoint activation and its absence suppresses the embryonic lethality and larval arrest observed infncm-1mutants. FANCM/CeFNCM-1 re-localizes upon hydroxyurea exposure and co-localizes with FANCD2/CeFCD-2 and LSD1/CeSPR-5 suggesting coordination between this histone demethylase and FA components to resolve replication stress. Surprisingly, the FA pathway is required for H3K4me2 maintenance regardless of the presence of replication stress. Our study reveals a connection between Fanconi Anemia and epigenetic maintenance, therefore providing new mechanistic insight into the regulation of histone methylation in DNA repair.
Determinants of ethical work behaviour of Malaysian public sector auditors
Authors: Ismail Suhaiza , Yuhanis Nursia 
Published: February 2018

Purpose
The purpose of this paper is to investigate factors affecting ethical work behaviour among Malaysian public sector auditors. Based on Hunt and Vitell model, there are four research objectives for this study: to investigate the influence of ethical climate on public sector auditors ethical work behaviour; to examine the effect of professional commitment on ethical work behaviour of public sector auditors; to investigate the effect of corporate ethical values (CEV) on ethical work behaviour of public sector auditors; and to examine the effect of ethical ideology on ethical work behaviour of public sector auditors.

Design/methodology/approach
The respondents of the study were public sector auditors of National Audit Department in Malaysia. Using a survey questionnaire comprising instruments about the ethical climate, CEV, professional commitment, ethical ideology and organisational misbehaviour, a total of 382 were received and usable. In achieving the research objectives, multiple regressions were performed.

Findings
The results reveal that ethical work behaviour among public sector auditors in Malaysia is influenced by law and independence ethical climate, professional commitment, CEV and both idealism and relativism ethical ideology.

Originality/value
The present study provides new additional empirical evidence on determinants of ethical work behaviour of auditors in public sector from a developing economy (i.e. Malaysia) which is currently limited.
Perception of hospital environment before and after relocation
Authors: Reijula Jori , Ruohomäki Virpi 
Published: February 2018

PurposeThis study assessed employees’ perceptions of their hospital work environment, its quality and functionality, as well as their satisfaction and well-being both before and after relocation within the hospital campus.Design/methodology/approachThe study was carried out in a Finnish University Hospital. Employees from the anesthesia, orthopedics and physiatrics department took part in the study. The data were collected from the employees with online questionnaires before and after the relocation. The statistical differences between the questionnaire variables were analyzed using the Chi-square test.FindingsRemarkable improvements in the quality of the new workplace included ability to adjust temperature, ventilation and furniture, ability to see out of windows, accessibility, number of meeting rooms, places to discuss confidential matters, quality of interior design, improved work satisfaction and desire to implement Lean. Significant deteriorations after relocation included unsettled work environment, impaired quality of cooperation and decreased interaction between employees.Originality/valueThis study discovered several improvements in the new facilities that had a visible effect on the assessed employee satisfaction and well-being parameters. The paper contains new, significant information that is relevant to the hospital facilities management and provides insight about the pros and cons of relocation and wherein their focus should be placed.
Living where you work
Authors: Carswell Andrew T. 
Published: February 2018

Purpose
This paper aims to examine whether property managers who live on-site within a residential apartment building provide a value-added benefit to the management in the form of cost control and revenue maximization.

Design/methodology/approach
This research uses two large US data sets that cover operational and financial data of apartment owners/operators and the financial and individual housing situations of renters themselves. The regression models developed were general linear models with operating expenses, rent collection and monthly rent paid as dependent variables, with on-site resident manager status as the experimental variable.

Findings
This research finds that the value of on-site property managers does not definitively maximize rent revenue, as expected. On-site property managers also don’t show significant reductions in operating expenses, although they are not cost centers either. Individual renter households do, however, pay a significant rent premium for units in communities with on-site personnel living there.

Research limitations/implications
The limitations of this research include the inability to merge the two data sets and the inability to measure the intangible attributes of the on-site residential manager’s experience.

Practical implications
As roughly 30 per cent of US rental apartment buildings have some form of on-site manager, this research has some practical implications for multifamily housing investors/owners, a highly visible US building sector.

Social implications
The action of hiring an on-site residential property manager also addresses issues related to the optimization and efficient allocation of human resources for property management companies.

Originality/value
This appears to be the first research addressing property managers who live at the site where they also work.
The NLS-based nonlinear grey Bernoulli model with an application to employee demand prediction of high-tech enterprises in China
Authors: Pei Lingling , Li Qin , Wang Zhengxin 
Published: February 2018

Purpose
The purpose of this paper is to propose a new method based on nonlinear least squares (NLS) for solving the parameters of nonlinear grey Bernoulli model (NGBM(1,1)) and to verify the proposed model using the case of employee demand prediction of high-tech enterprises in China.

Design/methodology/approach
First of all, minimising the square sum of fitting error of grey differential equation of NGBM(1,1) is taken as the optimisation target and the parameters of classic grey model (GM(1,1)) are set as the initial value of parameter vector. Afterwards, the structural parameters and power exponents are solved by using the Gauss-Newton iteration algorithm so as to calculate the parameters of NGBM(1,1) under given rules for ceasing the algorithm. Finally, by taking the employee demand of high-tech enterprises in the state-level high-tech industrial development zone in China as examples, the validity of the new method is verified.

Findings
The results show that the parameter estimation algorithm based on the NLS method can effectively identify the power exponents of NGBM(1,1) and therefore can favourably adapt to the nonlinear fluctuations of sequences. In addition, the algorithm is superior to the GM(1,1) model, grey Verhulst model, and Quadratic-Exponential smoothing algorithm in terms of the simulation and prediction accuracy.

Research limitations/implications
Under the framework of solving parameters based on NLS, various aspects of NGBM(1,1) remain to be further investigated including background value, initial condition and variable structural modelling methods.

Practical implications
The parameter estimation algorithm based on NLS can effectively identify the power exponent of NGBM(1,1) and therefore it can favourably adapt to the nonlinear fluctuation of sequences.

Originality/value
According to the basic principle of NLS, a new method for solving the parameters of NGBM(1,1) is proposed by using the Gauss-Newton iteration algorithm. Moreover, by conducting the modelling case about employees demand in high-tech enterprises in China, the effectiveness and superiority of the new method are verified.
The effect of service charge responsibilities on tenants’ leasing experience and satisfaction
Authors: Halvitigala Dulani 
Published: February 2018

Purpose
Despite the growing diversity of lease structures in different global economies, the existing literature related to property service charge mechanisms has been largely confined to the UK property market. This study aims to examine tenants’ perceptions, experiences and satisfaction with being responsible for service charges in New Zealand, where major office submarkets are dominated by alternative forms of leases with different service charge responsibilities.

Design/methodology/approach
The study uses a structured survey of 107 major tenants of New Zealand’s listed property trust-owned properties located in Auckland (where net leases dominate) and Wellington (where gross leases dominate) complemented by ten in-depth interviews with senior property managers of tenant organisations. The collected data were analysed using various statistical tests and thematic analysis.

Findings
The results identify that tenants who are directly responsible for service charges are significantly more dissatisfied with their operating expenses (OPEX) responsibilities than tenants who do not have direct service charge responsibilities. They are dissatisfied with the interpreting, budgeting, calculating, accounting, allocating and auditing processes in the service charge management process. Tenants who are directly responsible for service charges are significantly more dissatisfied with the operation and maintenance procedures of their buildings and have weaker relationship strengths with landlords. Tenant perceptions of being responsible for service charges vary with their power relationship with the landlord, lease expectations and priorities, financial constraints, willingness to take part in the management of the premises and trust in the landlord.

Originality/value
This research highlights the importance of understanding the complexity of service charge mechanisms in countries where there are no regulations or codes of practice governing them and their impact on tenant leasing behaviours, experiences and satisfaction. Here, the importance of developing more widely applicable codes of practice representing countries with different lease environments is highlighted. The findings also emphasise the importance of understanding the dynamics of key market agents that actively create lease environments and how they interact and behave within these contexts.
The role of compliance for organisational change
Authors: Busse Ronald , Doganer Ufuk 
Published: February 2018

PurposeFuelled by the latest scandals at Siemens, VW or Walmart, there is a lively debate on the role of compliance and ethics programmes. Unlike large corporations, small and medium-sized enterprises (SMEs) arguably tend to underestimate their significance and lag behind. Hence, the purpose of this paper is to shed light on the process of introducing compliance codes and its effects on employee acceptance and performance.Design/methodology/approachIn line with the qualitative methodology, the authors conducted 12 in-depth interviews with German SME employees which the authors evaluated with the qualitative content analysis.FindingsAs for the major contribution, results indicate the emergence of a lack of understanding, anger, anxiety and operational performance losses – both at the individual and the corporate level – especially when employees feel uninvolved in the initial introduction stadium.Originality/valuePracticing managers may benefit from the recommendation to facilitate staff involvement at earlier stages. As for theory advancement, the authors draw on Kotter’s (2007) long surviving “Eight Steps Change Management Model” and find significant support for shifting the spotlight of attention towards the first four phases. The authors discuss the original value of the research, admit limitations and illuminate some promising future research trajectories.
Planned organisational change management
Authors: Rosenbaum David , More Elizabeth , Steane Peter 
Published: February 2018

PurposeThe purpose of this paper is to identify the development of planned organisational change models (POCMs) since Lewin’s three-step model and to highlight key linkages between them.Design/methodology/approachA total of 13 commonly used POCMs were identified and connections with Lewin’s three-step framework and associated process attributes were made, reflecting the connections between these models and Lewin.FindingsThe findings show that first Lewin’s three-step model represents a framework for planned change; however, these steps could not be viewed in isolation of other interrelated processes, including action research, group dynamics, and force field analysis. These process steps underpin the iterative aspects of his model. Second, all 13 POCMs have clearly identified linkages to Lewin, suggesting that the ongoing development of POCMs is more of an exercise in developing ongoing procedural steps to support change within the existing framework of the three-step model.Research limitations/implicationsThe authors recognise that the inclusion of additional POCMs would help strengthen linkages to Lewin. The findings from this paper refocus attention on the three-step model, suggesting its ongoing centrality in planned organisational change rather than it being dismissed as an historical approach from which more recently developed models have become more relevant.Practical implicationsThis paper presents opportunities for organisational change management researchers to challenge their thinking with regard to the ongoing search for model refinement, and for practitioners in the design and structure of POCM.Originality/valueAn analysis of the ongoing relevance of Lewin and his linkage with modern POCMs assist in rationalising the broadening, and often confusing literature on change. This paper therefore not only contributes to filtering such literature, but also helps clarify the myriad of POCMs and their use.