bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal medullary carcinomas depend uponSMARCB1loss and are sensitive to proteasome inhibition
Authors: Hong Andrew L. , Tseng Yuen-Yi , Wala Jeremiah , Kim Won Jun , Kynnap Bryan D. , Doshi Mihir B. , Kugener Guillaume , Sandoval Gabriel J. , Howard Thomas P. , Li Ji , Yang Xiaoping , Tillgren Michelle , Ghandi Mahmoud , Sayeed Abeer , Deasy Rebecca , Ward Abigail , McSteen Brian , Labella Katherine M. , Keskula Paula , Tracy Adam , Connor Cora , Clinton Catherine M. , Church Alanna J. , Crompton Brian D. , Janeway Katherine A. , Hare Barbara Van , Sandak David , Gjoerup Ole , Bandopadhayay Pratiti , Clemons Paul A. , Schreiber Stuart L. , Root David E. , Gokhale Prafulla C. , Chi Susan N. , Mullen Elizabeth A. , Roberts Charles W. M. , Kadoch Cigall , Beroukhim Rameen , Ligon Keith L. , Boehm Jesse S. , Hahn William C. 
Published: December 2018

AbstractRenal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. Through direct-to-patient outreach, we developed genomically faithful patient-derived models of RMC. Using whole genome sequencing, we identified intronic fusion events in oneSMARCB1allele with concurrent loss of the other allele, confirming that SMARCB1 loss occurs in RMC. Biochemical and functional characterization of these RMC models revealed that RMC depends on the loss ofSMARCB1for survival and functionally resemble other cancers that harbor loss ofSMARCB1, such as malignant rhabdoid tumors or atypical teratoid rhabdoid tumors. We performed RNAi and CRISPR-Cas9 loss of function genetic screens and a small-molecule screen and identifiedUBE2Cas an essential gene in SMARCB1 deficient cancers. We found that the ubiquitin-proteasome pathway was essential for the survival of SMARCB1 deficient cancersin vitroandin vivo.Genetic or pharmacologic inhibition of this pathway leads to G2/M arrest due to constitutive accumulation of cyclin B1. These observations identify a synthetic lethal relationship that may serve as a therapeutic approach for patients with SMARCB1 deficient cancers.
Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s disease
Authors: Bomba Manuela , Granzotto Alberto , Castelli Vanessa , Lattanzio Rossano , Cimini Annamaria , Sensi Stefano L. 
Published: December 2018

AbstractBackgroundpreclinical, clinical, and epidemiological evidence support the notion that Alzheimer’s disease(AD) is a multifactorial condition in which, along with β-amyloid (Aβ) and tau-related pathology, the synergistic activity of genetic, environmental, vascular, metabolic, and inflammatory factors promote the onset and progression of the disease. Epidemiological evidence indicate that glucose intolerance, deficits in insulin secretion or type 2 diabetes mellitus (T2DM) participate in increasing the risk of developing cognitive impairment or dementia. A pivotal role in the process is played by insulin as the hormone critically regulates brain functioning. GLP-1, the glucagon-like peptide 1, facilitates insulin signaling, regulates glucose homeostasis, and modulates synaptic plasticity. Exenatide is a GLP-1R agonist, characterized by an extended half-life, employed in T2DM. However, exenatide has also been shown to affect the signaling of the brain-derived neurotrophic factor (BDNF), synaptic plasticity, and cognitive performances in animal models of brain aging and neurodegeneration.Methodsin this study, we tested whether exenatide exerts neuroprotection in a preclinical AD model set to mimic the clinical complexity of the human disease. To that aim, we investigated the effects of 3-month exenatide treatment in 3xTg-AD mice challenged for six months with a high-fat diet (HFD). Endpoints of the study were variations in systemic metabolism, insulin and neurotrophic signaling, neuroinflammation, levels of Aβ and tau pathology as well as changes in cognitive performances.Findings and interpretationresults of the study indicate that exenatide reverts the adverse changes of BDNF signaling and the neuroinflammation status of 3xTg-AD mice undergoing HFD.
Boundary conditions for early life converge to an organo-sulfur metabolism
Authors: Goldford Joshua E. , Hartman Hyman , Marsland Robert , Segrè Daniel 
Published: December 2018

AbstractIt has been suggested that a deep memory of early life is hidden in the architecture of metabolic networks, whose reactions could have been catalyzed by small molecules or minerals prior to genetically encoded enzymes (1–6). A major challenge in unraveling these early steps is assessing the plausibility of a connected, thermodynamically consistent proto-metabolism under different geochemical conditions, which are still surrounded by high uncertainty. Here we combine network-based algorithms (9, 10) with physicochemical constraints on chemical reaction networks to systematically show how different combinations of parameters (temperature, pH, redox potential and availability of molecular precursors) could have affected the evolution of a proto-metabolism. Our analysis of possible trajectories indicates that a subset of boundary conditions converges to an organo-sulfur-based proto-metabolic network fueled by a thioester- and redox-driven variant of the reductive TCA cycle, capable of producing lipids and keto acids. Surprisingly, environmental sources of fixed nitrogen and low-potential electron donors seem not to be necessary for the earliest phases of biochemical evolution. We use one of these networks to build a steady-state dynamical metabolic model of a proto-cell, and find that different combinations of carbon sources and electron acceptors can support the continuous production of a minimal ancient “biomass” composed of putative early biopolymers and fatty acids.
Hfq Globally Binds and Destabilizes the bound sRNAs and mRNAs in Yersinia pestis
Authors: Han Yanping , Chen Dong , Yan Yanfeng , Wang Hongduo , Liu Zizhong , Xue Yaqiang , Yang Ruifu , Zhang Yi 
Published: December 2018

ABSTRACTHfq is a ubiquitous Sm-like RNA binding protein in bacteria involved in physiological fitness and pathogenesis, while its in vivo binding natures still remain elusive. Here we reported the first study of the Hfq-bound RNAs map in Yersinia pestis, the causative agent of a kind of plague, by using Cross-Linking Immunoprecipitation coupled with deep sequencing (CLIP-Seq) approach. We show that Hfq binds over 80% mRNAs of Y. pestis, and also globally binds non-coding sRNAs encoded by the intergenic, antisense, and the 3’ regions of mRNAs. Hfq U-rich stretch is highly enriched in sRNAs, while motifs partially complementary to AGAAUAA and GGGGAUUA are enriched in both mRNAs and sRNAs. Hfq binding motifs are enriched at both terminal sites and in the gene body of mRNAs. Surprisingly, a large fraction of the sRNA and mRNA regions bound by Hfq and those downstream are destabilized, likely via a 5’P-activated RNase E degradation pathway and consistent with Hfq-facilitated sRNA-mRNA base-pairing and the coupled degradation in Y. pestis. These results together have presented a high-quality Hfq-RNA interaction map in Y. pestis, which should be important for further deciphering the regulatory role of Hfq-sRNAs in Y. pestis.AUTHOR SUMMARYDiscovered in 1968 as an Escherichia coli host factor that was essential for replication of the bacteriophage Qβ, the Hfq protein is a ubiquitous and highly abundant RNA binding protein in many bacteria. Under the assistance of Hfq, small RNAs in bacteria play important role in regulating the stability and translation of mRNAs by base-pairing. In this study, we want to elucidate the Hfq assisted sRNA-mRNA regulation in Yersinia pestis. A global map of Hfq interaction sites in Y. pestis was obtained by sequencing of cDNAs converted from the Hfq-bound RNA fragments using UV cross-linking coupled immunoprecipitation technology. We demonstrate that Hfq could hundreds of sRNAs and the majority of mRNAs in living Y. pestis. The enriched binding motifs in sRNAs and mRNA are significantly complementary to each other, suggesting a general base-pairing mechanism for sRNA-mRNA interaction. The Hfq-bound sRNA and mRNA regions were both destabilized. The results suggest that Hfq binding facilitates sRNA-mRNA base-pairing and coordinates their degradation, which might enable Hfq to surveil the hemostasis of most mRNAs in bacteria.
Analysis of BIM use for asset management in three public organizations in Québec, Canada
Authors: Brunet Maude , Motamedi Ali , Guénette Louis-Martin , Forgues Daniel 
Published: December 2018

Purpose
Given the ongoing digital transformation, building information modeling (BIM) has great potential to create a collaborative environment in the whole lifecycle of the built asset, from inception to decommissioning. The paper aims to discuss this issue.

Design/methodology/approach
This paper relates current developments in Québec with regard to the use of BIM for asset management (AM). The steps taken by three public organizations to develop their capabilities and take advantage of new possibilities are presented. The main methodological approach is based on participant observation, through case studies complemented by a questionnaire.

Findings
This paper reports on results and analysis of an important module of a broader research project on the impact of new technologies and collaborative methods for projects and AM. The results of this first research module points to the importance of using pilot projects to develop a continuous improvement approach, where feedback loops from projects support the development of AM capabilities and culture. Another important finding is the importance of sharing experience for the three public organizations involved.

Originality/value
The main contributions of this paper are to document this overarching research program and to gain deeper insights by reflexively considering the steps taken and the ones ahead for the quest to enhance the transfer of information for built assets at the end of projects to the operations and maintenance phase and to use BIM for operation.
Enhancing business process execution with a context engine
Authors: Janiesch Christian , Kuhlenkamp Jörn 
Published: December 2018

Purpose
Changes in workflow relevant data of business processes at run-time can hinder their completion or impact their profitability as they have been instantiated under different circumstances. The purpose of this paper is to propose a context engine to enhance a business process management (BPM) system’s context-awareness. The generic architecture provides the flexibility to configure processes during initialization as well as to adapt running instances at decision gates or during execution due to significant context change.

Design/methodology/approach
The paper discusses context-awareness as the conceptual background. The technological capabilities of business rules and complex event processing (CEP) are outlined in an architecture design. A reference process is proposed and discussed in an exemplary application.

Findings
The results provide an improvement over the current situation of static variable instantiation of business processes with local information. The proposed architecture extends the well-known combination of business rules and BPM systems with a context engine based on CEP.

Research limitations/implications
The resulting architecture for a BPM system using a context engine is generic in nature and, hence, requires to be contextualized for situated implementations. Implementation success is dependent on the availability of context information and process compensation options.

Practical implications
Practitioners receive advice on a reference architecture and technology choices for implementing systems, which can provide and monitor context information for business processes as well as intervene and adapt the execution.

Originality/value
Currently, there is no multi-purpose non-proprietary context engine based on CEP or any other technology available for BPM, which facilitates the adaptation of processes at run-time due to changes in context variables. This paper will stimulate a debate between research and practice on suitable design and technology.
Identification of barriers to PLM institutionalization in large manufacturing organizations
Authors: Singh Shikha , Misra Subhas Chandra 
Published: December 2018

Purpose
The purpose of this paper is to study the barriers to institutionalize the product lifecycle management (PLM) in large manufacturing organizations. The paper explores the hurdles and identifies the causal barriers to support the organizations’ transformation into digitized firms.

Design/methodology/approach
The paper utilized the multi-criteria decision making technique, i.e., DEMATEL (DEcision MAking Trial and Evaluation Laboratory) method to find the causal barriers, and adopted maximum mean de-entropy (MMDE) algorithm to determine the threshold value based on the information entropy of the relations among the barriers to PLM institutionalization.

Findings
This study explored nine barriers to PLM institutionalization and empirically identified the four critical barriers among the nine.

Research limitations/implications
The present work is exploratory case-based research which is limited to a case of an Indian aircraft manufacturing firm with a limited number of respondents. More sophisticated statistical tools can be utilized to consider the subjectivity of the respondents. However, this research explores the various hurdles to PLM success and serves as a relevant outcome to identify the critical barriers to institutionalize the PLM concept.

Practical implications
The findings of the paper provide guidelines to the case company and similar firms for obtaining maximum benefits of PLM. The methodology shown in this paper will be useful to various large scale industries in identifying the critical barriers to PLM institutionalization among all existing barriers so that they can take appropriate measures before they proceed to adopt PLM.

Originality/value
The present work discusses the different reasons for which the companies are not able to derive the maximum benefits of PLM even after the implementation of PLM systems. This work uniquely applied the DEMATEL and MMDE methods to investigate the critical barriers to PLM institutionalization in an aircraft manufacturing firm.
The buffering effects of CSR reputation in times of product-harm crisis
Authors: Kim Yeonsoo , Woo Chang Wan 
Published: December 2018

Purpose
The purpose of this paper is to examine the role of prior-CSR reputation in protecting a company’s CSR reputation during product-harm crises and how it influences consumers’ crisis-related behavioral intentions (i.e. supportive communication, resistance to negative information and crisis resiliency). The authors test whether the impact of prior-CSR reputation differs by crisis type as well.

Design/methodology/approach
A randomized 2 (CSR reputation: good vs bad) × 2 (product-harm crisis type: tampering vs preventable) full factorial design in two industry settings (food industry and retail industry) with consumer samples was conducted.

Findings
The results revealed the determinant role of positive prior-CSR reputation in protecting reputational assets. A company with positive CSR reputation experiences no decrease in its CSR reputation during victim crises and fairly minor decreases during preventable crises. However, a company with a bad prior-CSR reputation experiences a greater decline in its CSR reputation across both crises; the level of decline during victim crises was as substantial as the decline experienced during a preventable crisis. The prior-CSR reputation directly affects consumers’ crisis-related intentions, and indirectly does so through post-CSR reputation. As post-CSR reputation becomes more positive, consumers display greater resistance to negative information, supportive communication intent and crisis resiliency.

Originality/value
This study advances the understanding of the role of corporate reputation during crises and provides additional empirical evidence of how the buffering effect of CSR can extend beyond product-related intentions among consumers. The findings can induce companies to adopt CSR programs more systematically and proactively under a long-term strategic plan.
Uberization in Paris – the issue of trust between a digital platform and digital workers
Authors: Wentrup Robert , Nakamura H. Richard , Ström Patrik 
Published: December 2018

PurposeUsing the lens of Uber’s digital workers in Paris, the purpose of this paper is to investigate how the trust-building mechanism is constructed between a digital platform and its digital workers in a foreign market entry.Design/methodology/approachThis is a case study based on empirical data from in-depth interviews with 35 Uber drivers. A cross-disciplinary literature framework from mainly international business and internet geography theory and a reflexive qualitative methodology are applied.FindingsResults show that the relationship between the digital platform and the digital workers is characterized by mistrust and suffers from decreasing commitment levels soon after market entry. Uber mitigates its mistrust via control and scarce mechanisms. The digital drivers’ “illusionary freedom”, a state in which they feel they can log on and log off at any time, enables the digital platform to gradually lower its commitment. The authors find that the mistrust does not seem to hamper the digital platform’s business performance.Research limitations/implicationsThe paper mainly covers the digital workers’ perspective and the case of Uber’s market entry in Paris.Social implicationsThis paper implies that digitally conveyed control seems to come at the cost of lowered human trust. Given the pace at which digital control systems are permeating society, this could eventually lower the whole societal trust level.Originality/valueThe authors criticize incumbent international business theory for not being sufficiently able to explain a contemporary digital business logic and the authors challenge the general assumption that successful internationalization is built through trust. The authors contribute with the conceptualization of a new technical market entry mode for digital platforms – “digitally controlled proxies”.
Awareness and use of self-archiving options among academic librarians in Nigerian universities
Authors: Okeji Clement Chukwuma , Eze Monica Eberechukwu , Chibueze Nneka Maureen 
Published: December 2018

PurposeThe purpose of this study was to investigate the extent to which academic librarians in Nigerian universities use self-archiving options to make their research papers visible globally.Design/methodology/approachAn online survey was designed using SurveyMonkey software to collect data from 394 academic librarians in Nigerian Universities.FindingsThe study revealed that the academic librarians in Nigerian universities know and actually use self-archiving options such as ResearchGate, institutional repository and Academia.edu to self-archive their publications. While other promotional tools such as kudos, Mendeley.com and personal websites/servers are not popularly used by the academic librarians. Increased exposure of previously published work, broadens the dissemination of academic research generally, and increases institutions’ visibility were among the factors the academic librarians indicated as very important that motivate them to contribute their scholarly output to self-archiving options.Research limitations/implicationsOne major challenge to the study is that many academic librarians in Nigeria do not check their e-mails regularly to enable them to respond to a request to participate in an online survey; some of them do not have stable internet facilities, whereas others are reluctant to respond to an online questionnaire. These reasons led to a low response rate which makes it difficult to generalize findings.Practical implicationsFindings from the study will create awareness for academic librarians in developing countries to see the need to self-archive their pre-print and accepted version of their papers in different self-archiving platforms.Originality/valueSelf-archiving of papers by authors will lead to an increased visibility of the author and possible citation of the work and chances of collaboration with international colleagues for research projects.
Using fractional order weakening buffer operator to forecast the main indices of online shopping in China
Authors: Gao Xiao Hui , Wu Lifeng 
Published: December 2018

Purpose
The purpose of this paper is to predict the main economic indices of online shopping in China.

Design/methodology/approach
A fractional order weakening buffer operator (WBO) for the GM(1,1) model is put forward in order to solve the problem of limited nonlinear data. The order number of WBO can adjust in line with the scenario.

Findings
The experimental results indicate that the proposed method can consider the scenario and obtain more accurate forecasting results.

Originality/value
This study found that the slowdown of growth trend after the previous high speed expansion period will continue, and the online shopping sellers should make more efforts to develop potential consumers to increase its turnover.
An Integrated Computerised Maintenance Management System (I-CMMS) for IBS building maintenance
Authors: Ismail Zul-Atfi 
Published: December 2018

Purpose
The purpose of this paper is to focus on the development of an integrated computerised maintenance management system to improve the information storage of design and construction, diagnostic and defect risk assessments on IBS building through the integration of building information modelling (BIM).

Design/methodology/approach
The methodology used interviews with the IBS building client/maintenance contractor in Malaysia to gather information about maintenance management problems, approaches to address problems, information and communication technology implementation and use of emerging technologies, in addition to prototyping a system development life cycle for system development.

Findings
Relevant process flowchart documents of system development were obtained from the case study and reviewed to assist in providing an automation technique for decision-making and structural defect diagnostic operation through the integration of Visual Basic.Net, MS Access and Autodesk Revit software.

Originality/value
This research focuses on automatic bidirectional communications between an Expert System and BIM on a database level. Adoption of the approaches suggested in the research will enable the system to promote the development of zero IBS building maintenance.