bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yield, growth, and labor demands of growing maize, beans, and squash in monoculture versus the Three Sisters
Authors: Cryan Ty , Musselman Olivia , Baumgardner Aaron W. , Osborn Sadie , Beuscher Caroline J. , Stehn Caitlin , Burt Ariane , Chaaban Ramsey , Lopez Alexis , Lewis Giles , Mata Gabriela , Rothenberg Milo , Plascencia‐Marquez Ayelen , Greer Rani , Stremlau Rose , Murphy Halle , Newman Lia Rose , Merrill Annie , Wadgymar Susana M. 
Published: November 2024

Societal Impact StatementIntercropping techniques like the Three Sisters, where maize, beans, and squash are grown in an intermixed arrangement, have sustained communities in the Americas for thousands of years and continue to be practiced around the world. In collaboration with the Catawba Indian Nation, we assessed the yield and labor demands required when farming with Three Sisters versus monoculture arrangements. Our results illustrate how farmers could use different planting strategies depending on their priorities (e.g., maximizing yield) and available resources (e.g., conserving land, seeds, or labor). Studies like these can help inform food sovereignty programs and support cultural initiatives in Native communities.Summary

Many Native American communities have historically grown maize, beans, and squash in polyculture as the Three Sisters because of the reciprocal ecological benefits the species provide each other and the surrounding environment. For instance, archaeological remains indicate that the Catawba Indian Nation had grown the Three Sisters for hundreds of years before experiencing the expansion of the colonial market economy, a smallpox epidemic, and the drastic loss of land.
To support the Catawba Indian Nation's food sovereignty and traditional ecological knowledge initiatives, we assess the yield and labor demands of growing their traditional variety of maize, beans, and squash plants in the Three Sisters planting design versus in monoculture conditions.
While total maize yield was equivalent in monoculture and the Three Sisters, plants grew larger, had higher survival, and produced greater yield per plant and per unit area of land in the Three Sisters. [Correction added on 21 November 2024, after first online publication: The preceding sentence has been corrected.] Squash yield was highest in monoculture. Trellising bean plants in monoculture required the most labor, and altogether, yield per hour of labor was higher in monoculture than in the Three Sisters.
Ultimately, the most appropriate farming strategy for the Catawba Indian Nation to use will depend on their priorities (e.g., maximizing the production of one species versus all species). We discuss the challenges managers of small farms face when considering traditional versus modern agricultural methods and describe how a respectful partnership between the Catawba Nation and Davidson College expanded and enhanced the outcomes of this study.
Dangers of under‐treatment and over‐treatment with inhaled corticosteroids in children with asthma
Authors: Hayes Breanne , Mahady Stacey , McGuire Amber , Sforza Amanda , Sforza Joseph , Piedimonte Giovanni , Skoner David P. 
Published: November 2024

AbstractTwo children, both under the care of specialists for mild persistent asthma, flirted with mortality. One lost and one won the battle. A 16‐year‐old boy never received ICS therapy despite extensive airway inflammation and remodeling and died due to mismanagement of an asthma exacerbation. A 6‐year‐old girl developed iatrogenic Cushing's syndrome during 18 months of continuous treatment with high, FDA‐unapproved doses of both ICS and INCS and nearly died during an adrenal crisis. The role of ICS under‐treatment and over‐treatment and the possibility that recommendations in asthma guidelines and information in FDA package labels could have prevented both outcomes are explored.
Post‐Discharge Growth Among Extremely Preterm Infants With or Without Bronchopulmonary Dysplasia
Authors: Kimoto Yasuka , Hirata Katsuya , Hirano Shinya , Wada Kazuko , Moriichi Akinori , Ito Yoshiya , Cho Kazutoshi , Mizuno Katsumi , Toyoshima Katsuaki , Kushima Reiko , Ishii Nozomi , Yamaguchi Takeshi , Hashimoto Keiji , Yada Yukari , Kono Yumi 
Published: November 2024

ABSTRACTObjectiveThis study aimed to evaluate whether bronchopulmonary dysplasia (BPD) and home respiratory care (HRC) after discharge, including home oxygen therapy (HOT) or home mechanical ventilation (HMV), were associated with the growth of extremely preterm infants.Study DesignThis secondary study uses data from a study on the infant and early childhood development survey of low‐birth‐weight infants in the Health, Labor, and Welfare Science Research. We enrolled 788 singleton extremely preterm infants appropriate for gestational age (GA). BPD was defined as the requirement of supplemental oxygen or respiratory support at 36 weeks corrected GA. We compared trends of anthropometric measurements from age 0 to 5 years among infants with non‐BPD, BPD without HRC, and BPD with HRC.ResultsWe obtained 4113 weight and length measurements. At age 0−5 years, the BPD with the HRC group weighed less and was shorter than the other two groups. Lower GA and BPD status were significantly associated with growth failure of weight at 3 and 5 years after adjustment for potential risk factors. Lower GA was significantly associated with growth failure of length at 3 and 5 years. Conversely, although BPD status was significantly associated with growth failure of length at 3 years, it was not at 5 years.ConclusionAmong extremely preterm infants, BPD with HRC was associated with a significant growth delay at 0−5 years compared with non‐BPD and BPD without HRC. However, the effect of different severities of BPD on growth failure of length was attenuated with age.
Favipiravir pharmacokinetics in Thai adults with mild COVID‐19: A sub‐study of interpatient variability and ethnic differences in exposure
Authors: Prasanchaimontri Ing‐orn , Manosuthi Weerawat , Pertinez Henry , Owen Andrew , Niyomnaitham Suvimol , Sirijatuphat Rujipas , Charoenpong Lantharita , Cressey Tim R. , Copeland Katherine , Mokmued Phongpan , Chokephaibulkit Kulkanya 
Published: November 2024

AbstractThis sub‐study sought to characterize the pharmacokinetics (PK) of favipiravir (FPV) within Thai adults and quantitatively assess differences in exposure to those previously reported in other populations as a basis to understand putative differences in efficacy between studies conducted in different regions. It was nested within a prospective trial of adults with symptomatic COVID‐19 infection without pneumonia receiving 1800 mg FPV twice‐daily on day 1 and 800 mg twice‐daily thereafter. Individual PK profiles were fitted with a one‐compartment disposition model (first‐order absorption). Eight adults (seven female) with a median age of 39 years and BMI of 27.9 kg/m2 were included. Seven adults achieved plasma concentrations above the EC90 in vitro target (25 mg/L), with minimum–maximum concentrations decreasing with repeat dosing. The mean FPV apparent clearance observed in this study was 1.1 L/h (coefficient of variation [CV]: 60%), apparent volume of distribution 20.6 L (CV: 40%), absorption rate constant 6.1 h (CV: 100%), and 2.4 daily % change in apparent clearance (CV: 315%). Higher exposures were observed in these Thai adults compared with data from previous studies in Chinese, Japanese, and Turkish populations, respectively. Current FPV doses recommended in Thailand achieved target plasma concentrations with higher exposures than those described previously in other populations. The limited sample size prohibits firm conclusions from being drawn but the presented data warrants confirmation with a view to interrogate the appropriateness of doses used in randomized clinical trials that failed to demonstrate efficacy.
Pharmacokinetics and brain uptake of sodium selenate and selenium in naïve rats and a lateral fluid percussion injury rat model
Authors: Li Chenxu , Casillas‐Espinosa Pablo M. , Saletti Patricia Grandizoli , Chi Tina , Yamakawa Glenn , Silva Juliana , Hudson Matt , Liu Wei , Jones Nigel C. , Shultz Sandy R. , Ali Idrish , Mishra Usha , Cloyd James C. , Moshe ́ Solomon L. , Galanopoulou Aristea S. , O'Brien Terence J. , Coles Lisa D. 
Published: November 2024

AbstractPost‐traumatic epilepsy (PTE) is a life‐long complication of traumatic brain injury (TBI). The development of PTE is associated with neurological morbidity and increases the risk of mortality. An aim of EpiBioS4Rx (Epilepsy Bioinformatics Study for Antiepileptogenic Therapy) was to test potential therapies to prevent the development of PTE in the lateral fluid percussion injury (LFPI) rat model of TBI, in which rats were subjected to injury at the left parietal cortex. Sodium selenate has been reported to be antiepileptogenic post‐TBI in rodent models by activating protein phosphatase 2A and reducing phosphorylated tau (p‐tau) protein. We aimed to characterize the pharmacokinetics (PK) and brain uptake of sodium selenate using naïve control and LFPI rats. Rats received either a single bolus dose or a single bolus dose followed by a 7‐day subcutaneous minipump infusion of sodium selenate. Sodium selenate and selenium concentrations in plasma and brain were analyzed and used for PK estimation and brain exposure assessment. Selenium concentrations rapidly increased after sodium selenate administration, demonstrating biotransformation from sodium selenate to selenium. Sodium selenate and selenium PK parameters were estimated using non‐compartmental analysis. Sodium selenate clearance (CL/F) and volume of distribution (Vd/F) varied by dose and route of administration, suggesting differences in bioavailability and nonlinear pharmacokinetics at the doses tested. Brain‐to‐plasma partition coefficients (AUCbrain/AUCplasma) for sodium selenate and selenium were found to be 0.7–1.3 and 0.1–0.3 following single‐dose injection, respectively, indicating active transport of sodium selenate across the blood–brain barrier (BBB).
Dynamic spatial network simulation accounting for multiple ecological factors provides practical recommendations for biosecurity early detection and rapid response (EDRR) strategies
Authors: Cervigni Eleanor May , Pires Rodrigo , Trevenen Elizabeth Joan , Britton David , Waterhouse Barbara , Royer Jane Evelyn , Renton Michael 
Published: November 2024

AbstractBACKGROUNDGlobally the spread of invasive pests is being facilitated by increased human mobility and climate change. Simulation modelling can help assess biosecurity strategies for early detection and rapid response (EDRR), but has struggled to account for important factors in the invasion process, such as spatial and temporal variability in habitat suitability and connectivity; population dynamics; and multiple dispersal pathways.We developed a novel dynamic spatial network simulation approach based on spatial network theory that enables integration of a wider range of spatio‐temporal factors than previous studies, calibrated it against extensive historical trapping data, and applied it to comprehensively analyse the EDRR strategy for Oriental fruit fly (Bactrocera dorsalis; OFF) in northern Australia.RESULTSSimulations indicated that the chance of OFF reaching the mainland in the next 20 years could be up to 20% under the current EDRR strategy, depending on how optimistic or pessimistic model assumptions are, and highlighted possible improvements to the EDRR strategy for further consideration. Simulations under optimistic assumptions indicate that transport via wind is most important in OFF reaching the mainland, but under pessimistic assumptions transport via people carrying infected fruit becomes more important.CONCLUSIONOur new dynamic spatial network simulation approach can account for a wide range of spatio‐temporal ecological factors to provide practical real‐world recommendations. At a minimum, this approach only requires weather and population data, both of which are available globally from a variety of free and open sources, making it broadly applicable to assessing the EDRR strategies in place for different species in other locations. © 2024 Society of Chemical Industry.
Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence
Authors: Zhuo Jinzhong , Chu Lanhe , Liu Dongyu , Zhang Jinming , Chen Weimou , Huang Haohua , Yu Qi , Meng Xiaojin , Zou Fei , Cai Shaixi , Dong Hangming 
Published: November 2024

ABSTRACTTetrandrine (TET) is a minimally toxic drug extracted from the root of Stephania tetrandra. We previously demonstrated that TET could ameliorate pulmonary fibrosis (PF) by modulating autophagy. However, the mechanism behind TET's protective effects on PF remains unclear. In this study, we utilized 16S rRNA gene sequencing, nontargeted metabolomic analysis, and network pharmacology to identify changes in lung microbiota and metabolites that mediate alveolar epithelial cell senescence in bleomycin (BLM)‐induced PF in mice. Additionally, we employed Western blot analysis, RT‐PCR, and immunofluorescence staining to investigate the in vitro and in vivo effects of TET and its influential bacterial metabolites on PF. The TET intervention alleviated PF by regulating the compositions of lung microbial communities (Streptococcus, Micrococcus, Acinetobacter, Altererythrobacter, Atopostipes, Candidatus Cloacimonas, Clostridium sensu stricto 1, Sphingomonas, Listeria, Blautia, and Pseudomonas) and metabolites (3,4‐dihydroxyphenylpropionic acid (3,4‐DHPPA), 6‐Aminonicotinamide, N‐acetyl‐5‐methoxykynuramine, and resiniferatoxin). Through network pharmacological analysis, it was determined that 3,4‐DHPPA played a crucial role in alleviating PF by further inhibiting the senescence of alveolar epithelial cells, a finding further validated in ex vivo experiments. TET mitigated BLM‐induced PF in murine models through the modulation of lung microbiota composition and metabolism. Specifically, TET augmented the level of the microbiota‐derived metabolite, 3,4‐DHPPA, which in turn attenuated alveolar epithelial cell senescence.
Enterovirus Antibodies: Friends and Foes
Authors: Mbani Chaldam Jespère , Morvan Corentin , Nekoua Magloire Pandoua , Debuysschere Cyril , Alidjinou Enagnon Kazali , Moukassa Donatien , Hober Didier 
Published: November 2024

ABSTRACTEnteroviruses (EV) initiate replication by binding to their cellular receptors, leading to the uncoating and release of the viral genome into the cytosol of the host cell. Neutralising antibodies (NAbs) binding to epitopes on enteroviral capsid proteins can inhibit this infectious process through several mechanisms of neutralisation in vitro. Fc‐mediated antibody effector functions such as antibody‐dependent cell‐mediated cytotoxicity and antibody‐dependent cellular phagocytosis have also been described for some EV. However, antibody binding to virions does not always result in viral neutralisation. Non‐neutralising antibodies, or sub‐neutralising concentrations of antibodies, can enhance infection of viruses, leading to more severe pathologies. This phenomenon, known as antibody‐dependent enhancement (ADE) of infection, has been described in vitro and/or in vivo for EV including poliovirus, coxsackievirus B and EV‐A71. It has been shown that ADE of EV infection is mediated by FcγRs expressed by monocytes, macrophages, B lymphocytes and granulocytes. Antibodies play a crucial role in the diagnosis and monitoring of infections. They are valuable markers that have been used to establish a link between enteroviral infection and chronic diseases such as type 1 diabetes. Monoclonal and polyclonal antibodies targeting enteroviral proteins have been developed and shown to be effective to prevent or combat EV infections in vitro and in vivo. In addition, vaccines are under development, and clinical trials of vaccines are underway or have been completed, providing hope for the prevention of diseases due to EV. However, the ADE of the infection should be considered in the development of anti‐EV antibodies or safe vaccines.
The infinite framework: Enhancing sustainable development and circularity in value chains
Authors: Esteban‐Amaro Rosa , Estelles‐Miguel Sofia , Lengua Ismael , Yannou Bernard , Bouillass Ghada 
Published: November 2024

AbstractThe manufacturing sector is a major contributor to material consumption, pollution, and waste generation. Despite global actions and policies promoting sustainable development and circularity, the global economy has yet to show significant signs of change. This article introduces a framework designed to transform current value chains into collaborative networks, involving a wide range of stakeholders who take responsibility for the process. The study identifies key shortcomings of current systems‐thinking approaches, which often fail to effectively prioritise hotspots along the value chain and assess them from environmental, social, economic, and governance perspectives. The proposed framework addresses these gaps, contributing to a necessary paradigm shift towards sustainable production. The article utilises case examples from the photovoltaic and textile sectors to illustrate implementation. By creating an inclusive and enabling ecosystem, this framework empowers decision‐makers and stakeholders to develop resilient pathways through the co‐creation of initiatives and policies, aligning attitudes with sustainable production practices.
Theoretical Study on BiCoO3: Pressure‐Tuned Transformation of Structure, Magnetism, Charge, and Spin State
Authors: Meng Junling , Zhang Yao , Yao Fen , Huang Wan , Zhou Shuang , Zhang Lifang , Xu Na , Zhao Lina 
Published: November 2024

AbstractThe atomic structures, electronic structures, magnetic properties, and spin states of BiCoO3 multiferroic material under hydrostatic pressure are comprehensively investigated by using first‐principles calculation based on density functional theory. Firstly, we found the pressure‐tuned structural symmetry transition from tetragonal P4 mm (No. 99) to cubic Pmm (No. 221) space group. The structural transformation prompts the Co─O polyhedral coordination transfer from a CoO5 pyramidal to a CoO6 distorted octahedron. Secondly, the pressure‐induced magnetic change from C‐type antiferromagnetic state to ferromagnetic state and then to paramagnetic configuration occurred after continuous compression of the volume. Essentially, the fundamental reason for the transition of the magnetic structure lies in the change of the internal atomic structure, such as the pressure induced abrupt changes of Co─O bond length and <Co─O─Co> bond angle. Meanwhile, an obvious volume collapse was observed when the pressure was applied to 51–56 GPa. Finally, as the pressure increases, the magnetism changes from C‐type antiferromagnetic state to paramagnetic configuration, accompanying the transformation from high spin state with b2g2eg2a1g1b1g1 configuration in pyramid structure to low spin state with t2g6eg0 in octahedral field. Therefore, our results demonstrate that applied hydrostatic pressure in BiCoO3 can trigger the transformation of structure, magnetism, charge, and spin state.
In Situ Formed Continuous and Dense Inorganic Borate‐Based SEI for High‐Performance Li‐Metal Batteries
Authors: Liu Yuying , Huang Tao , Huang Zhencheng , Huang Weiyuan , Chen Jing , Jia Hao , He Xuanlong , Chen Weibin , Wei Haoran , Li Liewu , Ren Xiangzhong , Ouyang Xiaoping , Liu Jianhong , Ye Shenghua , Yang Xuming , Pan Feng , Zhang Qianling , Hu Jiangtao 
Published: November 2024

AbstractThe practical application of lithium metal batteries (LMBs) is largely hindered by the notorious lithium dendrite growth, low cycle efficiency associated with insufficient electrode–electrolyte interphase dynamics, and electrolyte combustion. Here, an advanced electrolyte using a combination of three kinds of salts dissolved in carbonate‐based solvents is developed. The salt anions dominate a primary solvation sheath, resulting in weak interaction between Li+ and the solvents, as well as the in situ formation of an inorganic‐rich bilayer solid electrolyte interface (SEI). The designed electrolyte enables high cycle stability in LMBs with a high‐loading NMC cathode (approximately 20 mg cm−2), exhibiting 89.89% capacity retention after 200 cycles with the cutoff voltage of 4.5 V. Cryo‐TEM characterization and density‐functional theory (DFT) calculations reveal that the borate‐based bilayer SEI, characterized by an exceptional dense structure, effectively suppresses lithium dendrite growth, and certify the crucial role of inorganic component continuity and density within the SEI, which surpasses the absorption and migration energy barrier in terms of significance. This profound understanding of SEI structure holds great potential for advancing the development of high‐stable LMBs and can be expanded to other battery system.
Construction of 2D/2D Pd Metallene/COFs System with Strong Internal Electric Field for Outstanding Solar Energy Photocatalysis
Authors: Hu Haijun , Sun Xiaodong , Li Hui , Pan Hongge , Ma Yali , Huang Hongwei , Ma Tianyi 
Published: November 2024

AbstractDue to the severe recombination of charge carriers, the photocatalytic activity of covalent organic frameworks (COFs) materials is limited. Herein, through simple ultrasound and stirring processes, the Pd metallene (Pde) is successfully combined with 2D COFs to form Pde/TpPa‐1‐COF (Pde/TPC) composites. Obviously, a strong internal electric field (IEF) is successfully formed in Pde/TPC hybrid materials, which significantly boosts the separation of photogenerated charges. In addition, the matched 2D structure of the two materials can also lead to electronic coupling effects, plentiful active sites, and shortened carrier migration paths. Thus, the Pde/TPC hybrid materials own extraordinary carrier separation ability with a longer carriers lifetime (3.3 ns for Pde/TPC and 2.7 ns for TPC), which can be proved series of photoelectrochemical and spectroscopic tests. Benefiting from the formation of IEF and the matched 2D structure, the 8% Pde/TPC demonstrates the highest photocatalytic H2 evolution efficiency, with H2 production rate reaching up to 5.85 mmol g−1 h−1, which is over 25 times greater than that of pristine COFs, also exceeding that of many reported COFs‐based photocatalysts. This research provides new perspectives and innovative approaches to further research on enhancing the internal electric field of COFs to promote their photocatalytic performance.