bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Analysis of Stress‐ and ECM‐Related Genes in Their Effect on Weight Regain
Authors: Roumans Nadia J.T. , Wang Ping , Vink Roel G. , van Baak Marleen A. , Mariman Edwin C.M. 
Published: February 2018

ObjectiveDuring weight loss, the volume of adipocytes decreases, leading to stress because of the misfit between the cell contents and the surrounding extracellular matrix (ECM). This stress can be resolved by remodeling the ECM or the restorage of triglycerides within the adipocytes. The objective of this study was to investigate the existence of a connection between stress‐related and ECM‐related genes that is associated with weight regain.MethodsThirty‐one participants with overweight or obesity followed a 5‐week very‐low‐calorie diet (500 kcal/d) with a subsequent 4‐week weight‐stable diet (WS), and then an uncontrolled 9‐month follow‐up. Adipose tissue biopsies were collected for microarray analysis. A correlation and interaction analysis was performed with the weight regain percentage (WR%) ([weight after follow‐up − weight after WS] ÷ weight after WS × 100%) by using two gene sets that were previously defined as “stress‐related” (n = 107) and “ECM‐related” genes (n = 277).ResultsDuring WS, a coexpression network of 8 stress‐related genes and 15 ECM‐related genes correlating with WR% could be constructed, with links to multiple biological processes. Interaction analysis between stress‐ and ECM‐related genes revealed that several gene combinations were highly related to weight regain.ConclusionsOur findings underscore the importance of the connection between stress‐ and ECM‐related genes in the risk for weight regain.
Maternal Metabolic Health Parameters During Pregnancy in Relation to Early Childhood BMI Trajectories
Authors: Montazeri Parisa , Vrijheid Martine , Martinez David , Basterrechea Mikel , Fernandez‐Somoano Ana , Guxens Monica , Iñiguez Carmen , Lertxundi Aitana , Murcia Mario , Tardon Adonina , Sunyer Jordi , Valvi Damaskini 
Published: February 2018

ObjectiveThe objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories.MethodsTwo thousand two hundred fifty‐one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories.ResultsChildren in the reference BMI trajectory had average size at birth followed by a slower BMI gain. Maternal prepregnancy obesity was associated with trajectories of accelerated BMI gain departing from either higher (relative risk ratio [RRR] = 1.77; 95% CI: 1.07‐2.91) or lower size at birth (RRR = 1.91; 95% CI: 1.17‐3.12). Gestational weight gain (GWG) above clinical guidelines was associated with a trajectory of higher birth size followed by accelerated BMI gain (RRR = 2.14; 95% CI: 1.53‐2.97). Maternal serum triglycerides were negatively associated with BMI trajectories departing from lower birth sizes. Gestational diabetes, maternal serum cholesterol, and C‐reactive protein were unrelated to children's BMI trajectories.ConclusionsMaternal prepregnancy obesity, GWG, and serum triglycerides are associated with longitudinal BMI trajectories in early childhood that may increase disease risk in later life. Health initiatives should promote healthy weight status before and during pregnancy to improve maternal and child health.
Benefits and Harms in Pivotal Trials of Oral Centrally Acting Antiobesity Medicines: A Systematic Review and Meta‐Analysis
Authors: Onakpoya Igho J. , Collins Dylan R.J. , Bobrovitz Niklas J.H. , Aronson Jeffrey K. , Heneghan Carl J. 
Published: February 2018

ObjectiveTo evaluate the benefits and harms of oral centrally acting antiobesity medicinal products in pivotal trials.MethodsThe European Medicines Agency and Federal Drug Administration websites, PubMed, and ClinicalTrials.gov were searched to identify pivotal trials used to gain marketing authorizations. Pivotal phase III trials on which marketing authorizations were based were included. The data were analyzed by using Cochrane Review Manager (RevMan), and quality assessments for each outcome were performed by using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE).ResultsFive products (16 trials with 24,555 participants) were included. Significantly more participants who took the antiobesity products achieved ≥ 5% reduction in body weight (risk ratio [RR] 2.39; 95% CI: 2.09‐2.74; GRADE = low). However, the products significantly increased the risk of adverse events (RR 1.12; 95% CI: 1.07‐1.17; GRADE = very low) and the risk of discontinuation because of adverse events (RR 1.52; 95% CI: 1.33‐1.74; GRADE = low). There were no significant differences for most outcomes between currently approved and withdrawn products.ConclusionsAlthough oral centrally acting antiobesity products generate modest weight losses, they also increase the risks of adverse events and discontinuations because of adverse events. The premarketing benefit‐to‐harm profiles of currently available products and products that were later withdrawn because of harms are similar. Targeted study designs, better outcomes reporting, and improved postmarketing monitoring of harms are needed.
Study of hydrogen bond dynamics in Nylon 6 crystals using IR spectroscopy and molecular dynamics focusing on the differences between α and γ crystal forms
Authors: Brela Mateusz Z. , Wójcik Marek J. , Boczar Marek , Onishi Erika , Sato Harumi , Nakajima Takahito , Ozaki Yukihiro 
Published: February 2018

AbstractProton dynamics of hydrogen bonds (HBs) in the α and γ form of Nylon 6 were investigated by Born–Oppenheimer molecular dynamics (BOMD). Our results show differences in the dynamic effects of interchain HB interactions between the α form and the γ form of Nylon 6. Analysis of the time course of the geometrical parameters of HBs along the BOMD simulations has shown that HBs are dynamically favored in the γ form of Nylon. The quantization of the NH stretching mode enables a detailed discussion of the strengths of HB interactions. Solving the Schrödinger equation for the snapshots of one‐dimensional proton potentials, extracted from the ab initio MD, enables the consideration of anharmonicity, thermodynamics, and approximate quantum effects on proton movement. A larger red shift of the NH stretching band was observed in the γ form compared with the α form. Our study shows that HBs are more stabilized in the γ form than in the α form, which is mainly due to the higher number of HBs. The distribution of HBs along the trajectory clearly reveals the preference of the γ form. The quantization of the NH motion enables the discussion of the differences in the IR spectra between the two forms.
Recent advances of in vitro culture systems for spermatogonial stem cells in mammals
Authors: Sahare Mahesh G. , Suyatno  , Imai Hiroshi 
Published: February 2018

AbstractBackgroundSpermatogonial stem cells (SSCs) in the mammalian testis are unipotent stem cells for spermatozoa. They show unique cell characteristics as stem cells and germ cells after being isolated from the testis and cultured in vitro. This review introduces recent progress in the development of culture systems for the establishment ofSSClines in mammalian species, including humans.MethodsBased on the published reports, the isolation and purification ofSSCs, identification and characteristics ofSSCs, and culture system for mice, humans, and domestic animals have been summarized.ResultsIn mice, cell lines fromSSCs are established and can be reprogrammed to show pluripotent stem cell potency that is similar to embryonic stem cells. However, it is difficult to establish cell lines for animals other than mice because of the dearth of understanding about species‐specific requirements for growth factors and mechanisms supporting the self‐renewal of culturedSSCs. Among the factors that are associated with the development of culture systems, the enrichment ofSSCs that are isolated from the testis and the combination of growth factors are essential.ConclusionProviding an example ofSSCculture in cattle, a rational consideration was made about how it can be possible to establish cell lines from neonatal and immature testes.
Adaptive nonlinear ship tracking control with unknown control direction
Authors: Guo Meichen , Xu Dabo , Liu Lu 
Published: February 2018

SummaryThis paper is to suggest a novel design for ship tracking control of the benchmark Norrbin nonlinear ship model under relaxed conditions. The challenges of the problem under investigation include the uncertain or absent information of the model time constant, the uncertain reference course, and the intrinsic environmental disturbances. We formulate the ship tracking control problem in terms of a nonlinear output regulation problem with unknown control direction and uncertain exosystems. To solve the problem, we first adopt a novel internal model candidate to convert the output regulation problem into a stabilization problem for an augmented system. Then, a Nussbaum‐gain‐based stabilizer is developed for the augmented system to complete the design. Simulation results are presented to show the effectiveness of the proposed controller.
Enhanced Photocatalytic Degradation of Methyl Orange by Au/TiO2 Nanoparticles under Neutral and Acidic Solutions
Authors: Tsuji Masaharu , Matsuda Kanako , Tanaka Mayu , Kuboyama Satsuki , Uto Keiko , Wada Nozomi , Kawazumi Hirofumi , Tsuji Takeshi , Ago Hiroki , Hayashi Jun‐ichiro 
Published: February 2018

AbstractA comparative study was carried out on the degradation of methyl orange (MO) by TiO2 and Au/TiO2 photocatalysts in neutral and acidic solutions. Au/TiO2 photocatalysts with an Au : Ti atomic ratio of 1.5±0.1% : 98.5±0.1% were prepared by using a microwave‐polyol method in the presence of P25 TiO2. Initial degradation rates of MO by TiO2 and Au/TiO2 were 0.13 and 0.22 min−1 at pH 7, whereas they increased to 0.96 and 3.06 min−1 at pH 2, respectively. These results indicate that the MO degradation rates are enhanced by loading Au nanoparticles on TiO2 in neutral and acidic solutions by factors of 1.7 and 3.2, respectively. Mass spectroscopic studies lead us to conclude that major reaction products are formed by demethylation and OH addition of benzenoid form of MO in neutral solutions, whereas they are produced through ring opening and carboxylation of quinonoid form of MO after scission of a center N‐NH bond in acidic solutions. The relative importance of electron trapping and surface plasmon resonance (SPR) effects of Au nanoparticles is discussed for the enhancement of photocatalytic activity of Au/TiO2.
A Quick Micelle‐Catalyzed One‐Pot Synthesis of Spiro[indoline‐3, 4′‐pyrano[2, 3‐c]pyrazoles] in Water at Room Temperature
Authors: Devi Jutika , Kalita Subarna Jyoti , Deka Dibakar Chandra 
Published: February 2018

AbstractA quick, simple and cost‐effective, micelle catalyzed one‐pot strategy for the synthesis of spiro[indoline‐3, 4′‐pyrano[2, 3‐c]pyrazoles] by reacting isatins, malononitrile and 3‐methyl‐1H‐pyrazol‐5(4H)‐ones in water at room temperature is described. The notable advantages of the protocol are mild reaction conditions, simple purification process involving no chromatographic process, reusability of the catalyst and high yields in short reaction time which make the protocol highly attractive.
Brønsted Acidic Ionic Liquid‐Catalyzed Regioselective Synthesis of Pyrazolopyrimidines and Their Photophysical Properties
Authors: Singsardar Mukta , Sarkar Rajib , Majhi Koushik , Sinha Subrata , Hajra Alakananda 
Published: February 2018

AbstractA convenient and straightforward regioselective synthesis of pi‐conjugated pyrazolo[1, 5‐a]pyrimidines has been achieved via Brønsted acidic ionic liquid catalyzed tandem cyclization between 3‐aminopyrazole and chalcone derivatives in high yields. Task specific ionic liquid [1‐methyl‐3‐(4‐sulfobutyl)imidazolium‐4‐methylbenzenesulfonate] is found to be an effective catalyst for the cyclization, and the presence of both C2‐H of imidazolium moiety and acidic proton drastically enhance the catalytic activity. Substituted aminopyrazoles reacted with a wide range of functionalized α,β‐unsaturated ketones to variety of pyrazolo[1, 5‐a]pyrimidine derivatives. The present protocol offers a broad substrates scope, use of non‐hazardous reagent, metal‐free environmentally benign conditions and catalyst recyclability. Comparative photophysical studies have shown high quantum yields for certain derivatives.
Enantioselective Synthesis of 2,3‐Dihydrofurocoumarins by Squaramide‐Catalyzed Michael Addition/Cyclization of 4‐Hydroxycoumarins with β‐Nitrostyrenes
Authors: Modrocká Viktória , Veverková Eva , Baran Rastislav , Šebesta Radovan 
Published: February 2018

AbstractThis work describes the enantioselective synthesis of chiral 2,3‐dihydrofurocoumarins by squaramide‐catalyzed Michael addition of 4‐hydroxycoumarins to β‐nitrostyrenes, followed by a cyclization reaction. A coumarin moiety is present in many chiral bioactive compounds, but the organocatalysis has still not reached its full potential in the synthesis of chiral coumarins. Here, we used squaramide catalysts comprising two chiral units, (S)‐phenylethylamine and cyclohexane‐1,2‐diamine. These catalysts showed high reactivity and enantioselectivity in this transformation. Following this procedure, we prepared a series of 2,3‐dihydrofurocoumarin derivatives in 47‐93% yields and enantiomeric purities in the range of 78‐94% ee. Polystyrene‐immobilized squaramide catalyst performed well for the initial two reaction cycles but then slowly degraded. The absolute configuration of 2,3‐dihydrofurocoumarin products was determined by the comparison of the experimental and density functional theory‐calculated electronic circular dichroism spectra.
Magnetic Gated Biomimetic Artificial Nanochannels for Controllable Ion Transportation Inspired by Homing Pigeon
Authors: Hou Guanglei , Wang Dianyu , Xiao Kai , Zhang Huacheng , Zheng Shuang , Li Pei , Tian Ye , Jiang Lei 
Published: February 2018

AbstractThe homing pigeon‐inspired artificial nanochannel can be modulated by moderate magnetic field in a fast and noncontacting way. The ionic current, as well as rectifying ability and conductance is controlled by the magnetic field reversibly through elastic deformation of the nanochannel. Different gating effects are obtained at the two sides of the asymmetrically conical nanochannel due to the different response models. The magnetic gated nanochannel system also exhibits an excellent stability and a quick response in a noncontacting way, which may be promising in electronic devices related to biological or healthcare applications.
Flexible Lithium‐Ion Batteries with High Areal Capacity Enabled by Smart Conductive Textiles
Authors: Ha Sung Hoon , Shin Kyu Hang , Park Hae Won , Lee Yun Jung 
Published: February 2018

AbstractIncreasing demand for flexible devices in various applications, such as smart watches, healthcare, and military applications, requires the development of flexible energy‐storage devices, such as lithium‐ion batteries (LIBs) with high flexibility and capacity. However, it is difficult to ensure high capacity and high flexibility simultaneously through conventional electrode preparation processes. Herein, smart conductive textiles are employed as current collectors for flexible LIBs owing to their inherent flexibility, fibrous network, rough surface for better adhesion, and electrical conductivity. Conductivity and flexibility are further enhanced by nanosizing lithium titanate oxide (LTO) and lithium iron phosphate (LFP) active materials, and hybridizing them with a flexible 2D graphene template. The resulting LTO/LFP full cells demonstrate high areal capacity and flexibility with tolerance to mechanical fatigue. The battery achieves a capacity of 1.2 mA h cm−2 while showing excellent flexibility. The cells demonstrate stable open circuit voltage retention under repeated flexing for 1000 times at a bending radius of 10 mm. The discharge capacity of the unflexed battery is retained in cells subjected to bending for 100 times at bending radii of 30, 20, and 10 mm, respectively, confirming that the suggested electrode configuration successfully prevents structural damage (delamination or cracking) upon repeated deformation.
Amorphous Red Phosphorus Embedded in Sandwiched Porous Carbon Enabling Superior Sodium Storage Performances
Authors: Wu Ying , Liu Zheng , Zhong Xiongwu , Cheng Xiaolong , Fan Zhuangjun , Yu Yan 
Published: February 2018

AbstractThe red P anode for sodium ion batteries has attracted great attention recently due to the high theoretical capacity, but the poor intrinsic electronic conductivity and large volume expansion restrain its widespread applications. Herein, the red P is successfully encapsulated into the cube shaped sandwich‐like interconnected porous carbon building (denoted as P@C‐GO/MOF‐5) via the vaporization–condensation method. Superior cycling stability (high capacity retention of about 93% at 2 A g−1 after 100 cycles) and excellent rate performance (502 mAh g−1 at 10 A g−1) can be obtained for the P@C‐GO/MOF‐5 electrode. The superior electrochemical performance can be ascribed to the successful incorporation of red P into the unique carbon matrix with large surface area and pore volume, interconnected porous structure, excellent electronic conductivity and superior structural stability.
Tailoring Highly N‐Doped Carbon Materials from Hexamine‐Based MOFs: Superior Performance and New Insight into the Roles of N Configurations in Na‐Ion Storage
Authors: Liu Sitong , Zhou Jisheng , Song Huaihe 
Published: February 2018

AbstractTo prepare highly N‐doped carbon materials (HNCs) as well as to determine the influence of N dopants on Na‐ion storage performance, hexamine‐based metal–organic frameworks are employed as new and efficient precursors in the preparation of HNCs. The HNCs possess reversible capacities as high as 160 and 142 mA h g−1 at 2 A g−1 (≈8 C) and 5 A g−1 (≈20 C), respectively, and maintain values of 145 and 123 mA h g−1 after 500 cycles, thus exhibiting excellent rate and long‐term cyclic performance. Based on systematic analysis, a new insight into the roles of the different N configurations in Na‐ion storage is proposed. The adsorption of Na ions on pyridinic‐N (N‐6) and pyrrolic‐N (N‐5) is fully irreversible, whereas the adsorption on graphitic‐N (N‐Q) is partially reversible and the adsorption on N‐oxide (N‐O) is fully reversible. More importantly, the N‐6/N‐Q ratio is an intrinsic parameter that reflects the relationship between the N configurations and carbon textures for N‐doped carbons prepared from in situ pyrolysis of organic precursors. The cyclic stability and rate‐performance improve with decreasing N‐6/N‐Q ratio. Therefore, this work is of great significance for the design of N‐doped carbon electrodes with high performance for sodium ion batteries.
Edge‐Riched MoSe2/MoO2 Hybrid Electrocatalyst for Efficient Hydrogen Evolution Reaction
Authors: Jian Chuanyong , Cai Qian , Hong Wenting , Li Jing , Liu Wei 
Published: February 2018

AbstractMolybdenum diselenide (MoSe2) is widely considered as one of the most promising catalysts for the hydrogen evolution reaction (HER). However, the absence of active sites and poor conductivity of MoSe2 severely restrict its HER performance. By introducing a layer of MoO2 on Mo foil, MoSe2/MoO2 hybrid nanosheets with an abundant edge and high electrical conductivity can be synthesized on the surface of Mo foil. Metallic MoO2 can improve the charge transport efficiency of MoSe2/MoO2, thereby enhancing the overall HER performance. MoSe2/MoO2 exhibits fast hydrogen evolution kinetics with a small overpotential of 142 mV versus RHE at a current density of 10 mA cm−2 and Tafel slope of 48.9 mV dec−1.
Challenges in the development of green and sustainable software for software multisourcing vendors: Findings from a systematic literature review and industrial survey
Authors: Salam Muhammad , Khan Siffat Ullah 
Published: February 2018

AbstractGreen and sustainable software development has emerged in recent years, and vendors are constantly striving to develop software that has a less hazardous impact on the environment, economy, and human beings. However, developing green software in the context of software multisourcing is not a risk‐free activity, and vendors are exposed to several challenges. The authors have conducted both a systematic literature review and an industrial survey to identify the challenges faced by multisourcing vendors in the development of green and sustainable software. The final publication sample for the systematic literature review is composed of 54 research papers. Similarly, the final sample of the industrial survey is composed of 108 relevant experts. The authors have identified a list of 14 challenges. Of these challenges/risk factors, 8 have been tagged as critical risk factors. These critical risk factors are “lack of green RE practices,” “high power consumption,” “high carbon emission throughout the software development,” “poor software design (architectural, logical, physical, and user interface),” “lack of ICTs for coordination and communication,” “high resource requirements,” “lack of coding standards,” and “lack of green software development knowledge.”
Gram‐scale separation of borneol and camphor fromCinnamomum camphora(L.) Presl by continuous counter‐current chromatography
Authors: Yang Zhi , Guo Peipei , Han Rui , Wu Shihua , Gao Jin‐Ming 
Published: February 2018

AbstractBorneol and camphor are well known bicyclic monoterpenoids and have been widely used in food, senior aromatic spices and folk medicine in China, India and Japan for more than 2000 years. Although they can be obtained by recrystallization or sublimation, it is still a challenge to prepare high‐purity borneol and camphor with high yields. In this study, we introduce a new continuous counter‐current chromatography method for the gram‐scale preparation of borneol and camphor fromCinnamomum camphora(L.) Presl using heptane/ethyl acetate/methanol/water quaternary solvent system and heptane/methanol/water ternary solvent system. Compared to the heptane/ethyl acetate/methanol/water solvent system, the heptane/methanol/water solvent system was found to possess higher loading capacity, and the heptane/methanol/water (10:7:3, v/v/v) solvent system was found to be the optimal solvent system for the separation of the distillation products ofC. camphora. As a result, borneol and camphor were well obtained in a one‐step separation with a purity of over 99.9%. In addition, continuous injections method using “on demand” solvent system formulation was used to improve the separation efficiency and reduce solvent consumption, whose results indicated that counter‐current chromatography was a powerful and efficient tool to obtain borneol and camphor with high purity.