bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clustering of extremely red objects in the AKARI NEP-deep field
Authors: Seo Hyunjong , Jeong Woong-Seob , Shim Hyunjin , Kim Minjin , Ko Jongwan , Pyo Jeonghyun , Oi Nagisa , Goto Tomotsugu , Pearson Chris 
Published: June 2019

Abstract
We study the clustering property of extremely red objects (EROs) using Canada–France–Hawaii Telescope (CFHT) surveys with 0.55 deg2 in the AKARI north ecliptic pole (NEP) deep field. EROs are selected by the color criterion of r′ − Ks &gt; 3.66, which is equivalent to (R − Ks)Vega &gt; 5. We conducted the clustering analysis for two magnitude-limited cases, Ks &lt; 20.3 (N = 363) and Ks &lt; 20.9 (N = 727), using two-point angular correlation represented by a single power-law function. By fixing a power-law (with 0.8), the correlation lengths of EROs with Ks &lt; 20.3 and Ks &lt; 20.9 are 9.10 ± 1.86 and 7.81 ± 1.21 h−1 Mpc, respectively. We find that bias factors of EROs with Ks &lt; 20.3 and Ks &lt; 20.9 are 3.19 ± 0.59 and 2.83 ± 0.40, respectively, revealing that EROs reside in dark matter halos heavier than $\sim 10^{13}\, M_{\odot }$. To investigate possible descendants of EROs with Ks &lt; 20.9, we calculate how the bias for dark matter halos that host EROs evolves by accounting for mass growth of halos along the redshift. We find that halos hosting EROs evolve into halos hosting local massive galaxies with 2–$7\, L^{*}$. It suggests that passive EROs with Ks &lt; 20.9 are likely to be progenitors of massive galaxies in the present universe. The comparison between passive EROs (pEROs) and star-forming EROs (sEROs) classified by near-infrared colors shows that pEROs seem to be connected with more massive local galaxies. By fitting spectral energy distributions (SEDs), we estimate active galactic nucleus (AGN) contribution for 68 sEROs which are selected in mid-IR bands. AGN contributions to the IR luminosity are less than $10\%$ except for six sEROs. At least in the IR-selected sEROs, the contribution of AGN seems to be not significant.
Nanomedicine: an emerging era of theranostics and therapeutics for rheumatoid arthritis
Authors: Qamar Naila , Arif Ammara , Bhatti Attya , John Peter 
Published: June 2019

Abstract
RA is a multifactorial autoimmune inflammatory disease characterized by synovitis, bone destruction and joint dysfunction that leads to shortening of lifespan and increased mortality rates. Currently available treatments of RA, by controlling various symptoms, only delay disease progression and have their own side effects. Consequently, there is the need for a novel therapeutic strategy that offers a more sustainable and biocompatible solution. Nanomedicine is a modern branch of nanobiotechnology that provides targeted therapy to inflamed rheumatic joints and thus prevents unwanted off-target side effects. This review highlights various nanotheranostic and nanotherapeutic strategies that are currently being used for the treatment of RA.
RECENT TRITIUM CONCENTRATION OF MONTHLY PRECIPITATION IN JAPAN
Authors: Nakasone S , Ishimine A , Ishizu Y , Shiroma Y , Tanaka M , Akata N , Kakiuchi H , Sanada T , Furukawa M 
Published: June 2019

Abstract
To obtain a better understanding of recent tritium concentration and its seasonal cycle in Japan, monthly precipitation samples were collected in Hokkaido, Gifu and Okinawa prefectures from June 2014 to December 2017. The arithmetic mean ( ± standard deviation) of tritium concentrations in precipitation samples from Hokkaido, Gifu and Okinawa were estimated to be 0.62 ± 0.27 Bq L−1, 0.32 ± 0.12 Bq L−1 and 0.13 ± 0.05 Bq L−1, respectively. These results indicate that the concentrations increase with latitude. In addition, the highest and the lowest concentrations appeared in spring and summer, respectively. To clarify the origins and sources of these cycles, further analyses of chemical compositions of precipitation and meteorological conditions are needed.
Forever Homes and Temporary Stops: Housing Search Logics and Residential Selection
Authors: Harvey Hope , Fong Kelley , Edin Kathryn , DeLuca Stefanie 
Published: June 2019

Abstract
Residential selection is central in determining children’s housing, neighborhood, and school contexts, and an extensive literature considers the social processes that shape residential searches and attainment. While this literature typically frames the residential search as a uniform process oriented around finding residential options with desired characteristics, we examine whether individuals may differentially conceive of these searches in ways that sustain inequality in residential attainment. Drawing on repeated, in-depth interviews with a stratified random sample of 156 households with young children in two metropolitan counties, we find that parents exhibit distinct residential search logics, informed by the constraints they face. Higher-income families usually engage in purposive searches oriented around their residential preferences. They search for “forever homes” that will meet their families’ needs for years to come. In contrast, low-income parents typically draw on a logic of deferral. While they hope to eventually search for a home with the unit, neighborhood, and school characteristics they desire, aspirations for homeownership lead them to conceive of their moves (which are often between rental units) as “temporary stops,” which justifies accepting homes that are inconsistent with their long-term preferences. In addition, because they are often “pushed” to move by negative circumstances, they focus on their immediate housing needs and, in the most extreme cases, adopt an “anywhere but here” approach. These logics constitute an unexamined mechanism through which economic resources shape residential searches and ultimate attainment.
Parental Financial Transfers: Do They Vary by Children’s Sexual Orientation?
Authors: Perales Francisco , Huang Yangtao 
Published: June 2019

AbstractParents often play complex and highly variable roles in the lives of grown-up lesbian, gay and bisexual (LGB) people. Some act as support sources, helping their offspring buffer societal discrimination. Others are unaccepting of—or ambivalent about—their children’s sexual orientation, becoming further stressors. In practice, little research has examined whether parents treat adult LGB children differently than heterosexual children. This study tests this premise in relation to parental financial transfers using two waves of panel data from an Australian national sample (Household, Income and Labour Dynamics in Australia Survey, n = 18,448 observations) and random-effect panel regression models. We find that parents send money more often to LGB than heterosexual children, a pattern that persists over the adult life course. This association could not be explained by adult children’s socio-economic disadvantage, fertility intentions, parent-child contact, or parent-child distance. These findings suggest that, all else being equal, parental financial investments contribute to narrowing the social disadvantage experienced by Australian LGB people.
Better research by efficient sharing: evaluation of free management platforms for synthetic biology designs
Authors: Urquiza-García Uriel , Zieliński Tomasz , Millar Andrew J 
Published: June 2019

Abstract
Synthetic biology aims to introduce engineering principles into biology, for example, the construction of biological devices by assembling previously-characterized, functional parts. This approach demands new resources for cataloging and sharing biological components and designs, in order to accelerate the design-build-test-learn cycle. We evaluated two free, open source software platforms for managing synthetic biology data: Joint Bioenergy Institute-Inventory of Composable Elements (JBEI-ICE) and SynBioHub. We analyzed the systems from the perspective of experimental biology research groups in academia, which seek to incorporate the repositories into their synthetic biology workflow. Here, we define the minimal requirements for a repository in this context and develop three usage scenarios, where we then examine the two platforms: (i) supporting the synthetic biology design-build-test-learn cycle, (ii) batch deposit of existing designs into the repository and (iii) discovery and reuse of designs from the repository. Our evaluation of JBEI-ICE and SynBioHub provides an insight into the current state of synthetic biology resources, might encourage their wider adoption and should guide future development to better meet the needs of this user group.
Impact of Low-Dose Ionizing Radiation on the Composition of the Gut Microbiota of Mice
Authors: Liu Xiaodan , Zhou Yao , Wang Shaozheng , Guan Hua , Hu Sai , Huang Ruixue , Zhou Pingkun 
Published: June 2019

Abstract
Although the importance of the gut microbiota in the maintenance of human health has been well established, little is known about the impact of low-dose ionizing radiation ([LDR]; exposure to a dose of less than 0.5 Gy of low linear energy transfer radiation such as γ- or X-rays) on the composition and functional role of the gut microbiota. The aim of the present study was to investigate and compare the composition of the gut microbiota in mice exposed to LDR. Male BALB/c mice were exposed to low-dose Co60 radiation. Fecal samples taken prior to and after irradiation were used for high-throughput sequencing of 16S rRNA gene sequence amplicons. We observed substantial changes in the composition of the gut microbiota, including alpha diversity and beta diversity, in mice exposed to LDR compared with the nonradiated control group. Moreover, at the genus level, the abundance of Clostridium, Helicobacter, and Oscilibacter increased, and those of Bacteroides and Barnesiella decreased, in a time-dependent manner in the radiated groups compared with the nonradiated control group. The functional metabolic pathway analysis indicated that Bacteroides spp. and members of the other genera that were found are predicted to play roles in bacterial toxin production, DNA repair, and Type II diabetes. Furthermore, these alterations in the gut microbiota were accompanied by changes in the abundance of multiple metabolites, which were predicted to be involved in multiple signaling pathways, including glucagon, central carbon metabolism, and type II diabetes. The possibility of microbiota-mediated pathophysiology resulting from LDR may be an as yet unrecognized hazard that merits further experimental examination. This study provides a conceptual and analytical foundation for further research into the chronic effects of LDR on human health, and points to potential novel targets for intervention to prevent the adverse effects of radiation.
Computer Modeling of Prophylactic Dressings: An Indispensable Guide for Healthcare Professionals
Authors: Gefen Amit , Alves Paulo , Creehan Sue , Call Evan , Santamaria Nick 
Published: June 2019

ABSTRACT
This article is a review of the work conducted and published to date in employing computer finite element (FE) modeling for efficacy research of prophylactic dressings in the context of preventing pressure injuries. The authors strive to explain why FE modeling is essential in establishing the efficacy of prophylactic dressings, as it is in the development and evaluation of any other preventive intervention. In particular, FE modeling provides insights into the interactions between dressing structures and weight-bearing body tissues (including susceptible anatomical locations such as the sacrum and heels of supine patients). Modeling further facilitates reliable visualization and quantification of the mechanical loads that develop in superficial and deep tissues as a result of body weight or external forces based on known physical principles. The modeling then helps to determine how these tissue loads are mitigated using prophylactic dressings of different designs, structures, and material compositions and rate performances of existing or new products.
All of the work published so far on modeling the modes of action of prophylactic dressings has focused on the Mepilex Border dressing (Mölnlycke Health Care AB, Gothenburg, Sweden). Published work has revealed several key design features that are pivotal for obtaining successful clinical outcomes, namely, (1) a multilayered alternating-stiffness structure with embedded anisotropy; (2) a minimal friction coefficient at the external surface of the dressing; and (3) low impact of fluid retention on the mechanical behavior of the dressing. These features, their importance, and the methods of identifying their roles in the modes of action of effective prophylactic dressings are detailed here.
Computer models clearly inform the process of engineering prophylactic dressings, but they may also provide guidance in clinical use, contribute to assessing technologies and products, support purchasing, and describe product endurance. As the methods of FE modeling of dressings improve, simulations may soon incorporate the simultaneous complex interactions among tissue distortion, heat transfer in tissue, and prophylactic dressings to inform patient care.
Are genetics/genomics competencies essential for all clinical nurses?
Authors: Newcomb Patricia , Behan Deborah , Sleutel Martha , Walsh Judith , Baldwin Kathleen , Lockwood Suzy 
Published: June 2019

Abstract:
In 2006, the American Nurses Association created a set of essential genetics and genomics (G/G) competencies for all RNs, regardless of academic preparation, practice setting, or specialty. However, more than half of the RNs practicing today received no prelicensure education on these G/G competencies. This study describes the current use of G/G nursing competencies in acute care hospitals and how nurses perceive them.
Applicant Reactions to the AAMC Standardized Video Interview During the 2018 Application Cycle
Authors: Deiorio Nicole M. , Jarou Zachary J. , Alker Ashely , Bird Steven B. , Druck Jeffrey , Gallahue Fiona E. , Hiller Katherine M. , Karl Erin , Pierce Ava E. , Fletcher Laura , Dunleavy Dana 
Published: June 2019

Purpose
This study examined applicant reactions to the Association of American Medical Colleges Standardized Video Interview (SVI) during its first year of operational use in emergency medicine (EM) residency program selection to identify strategies to improve applicants’ SVI experience and attitudes.

Method
Individuals who self-classified as EM applicants applying in the Electronic Residency Application Service 2018 cycle and who completed the SVI in summer 2017 were invited to participate in 2 surveys. Survey 1, which focused on procedural issues, was administered immediately after SVI completion. Survey 2, which focused on applicants’ SVI experience, was administered in fall 2017, after SVI scores were released.

Results
The response rates for surveys 1 and 2 were 82.3% (2,906/3,532) and 58.7% (2,074/3,532), respectively. Applicant reactions varied by aspect of the SVI studied and their SVI total scores. Most applicants were satisfied with most procedural aspects of the SVI, but most applicants were not satisfied with the SVI overall or with their total SVI scores. About 20% to 30% of applicants had neutral opinions about most aspects of the SVI. Negative reactions to the SVI were stronger for applicants who scored lower on the SVI.

Conclusions
Applicants had generally negative reactions to the SVI. Most were skeptical of its ability to assess the target competencies and its potential to add value to the selection process. Applicant acceptance and appreciation of the SVI will be critical to the SVI’s acceptance by the graduate medical education community.
Late-Career Expectations: A Survey of Full-Time Faculty Members Who Are 55 or Older at 14 U.S. Medical Schools
Authors: Skarupski Kimberly A. , Welch Cheryl , Dandar Valerie , Mylona Elza , Chatterjee Archana , Singh Meenakshi 
Published: June 2019

Purpose
The average age of full-time faculty members at U.S. medical schools accredited by the Liaison Committee on Medical Education was 49.5 in 2017, yet the academic medicine community knows little about late-career faculty. The authors sought to characterize full-time faculty members 55 or older and assess their work–life expectations.

Method
The authors conducted a survey (May–September 2017) of faculty 55+ at 14 U.S. medical schools.

Results
Of the 5,204 faculty members invited, 2,126 (40.8%) responded. The average age of respondents was 62.3, and among those responding to the relevant questions, most identified as male (1,425; 67.2%), white (1,841; 88.3%), and married/partnered (1,803; 85.5%). Fewer than half (915; 45.2%) indicated they had begun thinking about full-time retirement, estimating that they would do so at a mean age of 67.8 (standard deviation = 4.3). Half the respondents (1,004; 50.0%) would consider moving to part-time status. The top 3 personal factors likely to affect retirement decisions were health, postretirement plans, and spouse’s/partner’s plans. The top 3 professional factors were phased retirement or part-time options, changes in institutional leadership, and presence of a successor. Faculty indicated that they would, post retirement, be interested in ongoing work in teaching/education and research/scholarship and that they wanted health insurance, email, and part-time teaching opportunities.

Conclusions
U.S. medical schools employ a rapidly aging workforce. These data indicate that neither faculty members nor institutions are prepared. Faculty affairs and develop ment leaders should champion efforts to engage with late-career faculty to prepare for this changing landscape.
Does Strategic Planning Matter?
Authors: Mallon William T. 
Published: June 2019

In this Invited Commentary, the author examines the history, use, and effectiveness of strategic planning in higher education, academic medicine, and nonprofit settings. Strategic planning is a process by which an organization differentiates itself from its direct or emergent competition to achieve its mission. This form of planning is distinct from operational planning, in which an organization identifies the ways in which it will continuously improve. Many organizations employ a combination of strategic planning and operational planning but use the former term to describe their planning process without a clear definition or conceptual framework.
The empirical literature across disciplines has not demonstrated that strategic planning leads to positive organizational outcomes. Over the modern history of academic medicine in the United States, strategic planning may have had limited impact on organizational outcomes because of favorable environmental circumstances that catalyzed growth and innovation regardless of planning efforts. In the current environment, organizational and departmental leaders need to define trade-offs between the various opportunities that they confront; allow for both planned and emergent strategy formulation; avoid platitudes and fluff; and focus on operational excellence.
Theories from anthropology suggest that strategic plans may be more important for what they express than what they produce. Repetition of the themes and language of strategy in formal and informal discourse can have a decisive effect on the culture of the organization. Strategic planning, therefore, matters for its effect on organizational values, rituals, and ability to move the organization in new directions.
Patient-specific ICP Epidemiologic Thresholds in Adult Traumatic Brain Injury: A CENTER-TBI Validation Study
Authors: Zeiler Frederick A. , Ercole Ari , Cabeleira Manuel , Beqiri Erta , Zoerle Tommaso , Carbonara Marco , Stocchetti Nino , Menon David K. , Lazaridis Christos , Smielewski Peter , Czosnyka Marek 
Published: June 2019

Background:
Patient-specific epidemiologic intracranial pressure (ICP) thresholds in adult traumatic brain injury (TBI) have emerged, using the relationship between pressure reactivity index (PRx) and ICP, displaying stronger association with outcome over existing guideline thresholds. The goal of this study was to explore this relationship in a multi-center cohort in order to confirm the previous finding.

Methods:
Using the Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit cohort, we derived individualized epidemiologic ICP thresholds for each patient using the relationship between PRx and ICP. Mean hourly dose of ICP was calculated for every patient for the following thresholds: 20, 22 mm Hg and the patient’s individual ICP threshold. Univariate logistic regression models were created comparing mean hourly dose of ICP above thresholds to dichotomized outcome at 6 to 12 months, based on Glasgow Outcome Score—Extended (GOSE) (alive/dead—GOSE≥2/GOSE=1; favorable/unfavorable—GOSE 5 to 8/GOSE 1 to 4, respectively).

Results:
Individual thresholds were identified in 65.3% of patients (n=128), in keeping with previous results (23.0±11.8 mm Hg [interquartile range: 14.9 to 29.8 mm Hg]). Mean hourly dose of ICP above individual threshold provides superior discrimination (area under the receiver operating curve [AUC]=0.678, P=0.029) over mean hourly dose above 20 mm Hg (AUC=0.509, P=0.03) or above 22 mm Hg (AUC=0.492, P=0.035) on univariate analysis for alive/dead outcome at 6 to 12 months. The AUC for mean hourly dose above individual threshold trends to higher values for favorable/unfavorable outcome, but fails to reach statistical significance (AUC=0.610, P=0.060). This was maintained when controlling for baseline admission characteristics.

Conclusions:
Mean hourly dose of ICP above individual epidemiologic ICP threshold has stronger associations with mortality compared with the dose above Brain Trauma Foundation defined thresholds of 20 or 22 mm Hg, confirming prior findings. Further studies on patient-specific epidemiologic ICP thresholds are required.
Intramedullary Fixation of Both Bone Forearm Fractures in Children and Adolescents: Healing Correlates With Development of the Olecranon Apophysis
Authors: Morrison Martin J. , Speirs Joshua N. , Chicorelli Anne M. , Garner Matthew , Flynn John (Jack) M. , Herman Martin J. 
Published: June 2019

Background:
The purpose of this study was to determine whether healing of both bone forearm (BBFA) fractures in children and adolescents is associated with the stage of the olecranon apophysis development as described by the Diméglio modification of the Sauvegrain method.

Methods:
Records were reviewed from 2 children’s hospitals from 1997 to 2008 to identify all patients younger than 18 years of age who had BBFA fractures treated with intramedullary nail fixation. Sixty-three patients were identified meeting inclusion and exclusion criteria. The stage of the olecranon apophysis was noted on the lateral radiograph at the time of the injury. Data were statistically analyzed to assess the olecranon stage at which the increased rate of delayed union becomes more prevalent using the receiver operating characteristic curve. Time to union, complications, and need for reoperation were recorded for each group.

Results:
One thousand three hundred ninety-eight patient records were reviewed with 63 patients meeting the inclusion criteria. Using a receiver operating characteristic curve, a cutoff of olecranon stage > 3 (stages 4 to 7) was a significant predictor of the increased rate of delayed union time compared with olecranon stages 0 to 3 (P=0.004). Non–healing-related complication rates for each group were 2/28 (7.1%) for olecranon stages and 0 to 3 and 6/35 (17.1%) for olecranon stages 4 to 7.

Conclusions:
The rate of delayed union for BBFA fractures that have been treated with intramedullary nail fixation is increased in children with more mature olecranon apophyses as compared with those with younger olecranon stages. We propose the use of the stage of olecranon apophysis development when choosing the surgical approach and implant for when treating operative BBFA fractures in children.

Level of Evidence:
Level III—retrospective comparative study.