bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nationwide survey of fetal myelomeningocele in Japan: Background for fetal surgery
Authors: Takahashi Yuka Otera , Wada Seiji , Miya Michiko , Akaishi Rina , Sugibayashi Rika , Ozawa Katsusuke , Endo Masayuki , Sago Haruhiko 
Published: May 2019

AbstractBackgroundFetal surgery for myelomeningocele (MMC) has yet not been performed in Japan, and the clinical background of fetal MMC in Japan remains poorly described. We examined the prenatal characteristics and perinatal outcomes of fetal MMC to prepare for the introduction of fetal surgery.MethodsA nationwide questionnaire survey was conducted with regard to fetuses with MMC between January 2012 and December 2014 at perinatal centers in Japan.ResultsIn 50 tertiary centers, 188 cases of MMC were identified, of which 126 (67%) were isolated cases. Only half of the cases involved referral to tertiary centers with a diagnosis of MMC. The median time point for a prenatal diagnosis was 26 weeks’ gestation (range, 12–38 weeks); in 54% of cases the diagnosis occurred after 26 gestational weeks, which is over the limit for fetal surgery for MMC. Furthermore, in 22% of cases the diagnosis was made before 22 gestational weeks, and in three‐quarters of these cases termination of pregnancy was selected. No fetal or neonatal deaths were observed in the isolated MMC group. MMC repair, ventriculoperitoneal shunt and clean intermittent catheterization were required after birth in 100%, 73% and 55% of isolated MMC cases, respectively. In total, 96% of the tertiary centers cared for <5 cases of fetal MMC per year.ConclusionsGestational age at MMC diagnosis was late mid‐gestation, therefore earlier detection is essential when considering fetal treatment of MMC in Japan. Although the survival rate was excellent, in three‐quarters of isolated MMC cases ventriculoperitoneal shunt was required. Early detection and centralization of MMC cases at specialized centers should be considered.
Rapid target selection of object categories based on verbs: Implications for language‐categorization interactions
Authors: van Bergen Geertje , Flecken Monique , Wu Rachel 
Published: May 2019

AbstractAlthough much is known about how nouns facilitate object categorization, very little is known about how verbs (e.g., posture verbs such as stand or lie) facilitate object categorization. Native Dutch speakers are a unique population to investigate this issue with because the configurational categories distinguished by staan (to stand) and liggen (to lie) are inherent in everyday Dutch language. Using an ERP component (N2pc), four experiments demonstrate that selection of posture verb categories is rapid (between 220–320 ms). The effect was attenuated, though present, when removing the perceptual distinction between categories. A similar attenuated effect was obtained in native English speakers, where the category distinction is less familiar, and when category labels were implicit for native Dutch speakers. Our results are among the first to demonstrate that category search based on verbs can be rapid, although extensive linguistic experience and explicit labels may not be necessary to facilitate categorization in this case.
Communication of a mesothelioma diagnosis: developing recommendations to improve the patient experience
Authors: Taylor Bethany Hope , Warnock Clare , Tod Angela 
Published: May 2019

BackgroundMalignant pleural mesothelioma (MPM) is an aggressive cancer linked to asbestos exposure and inhalation. As with other cancers, receiving a diagnosis of MPM is challenging and distressing. Particular challenges are associated with communicating a diagnosis of MPM, including explaining the disease and its prognosis, treatment options and legal and financial implications.ReceivingA DiagnosisOfMesothelioma (RADIO Meso) aimed to understand the experience of communicating a diagnosis of MPM from the perspective of patients, family carers and health professionals.MethodsThis qualitative study comprised 31 individual interviews with patients, family carers and health professionals. This was followed by two group interviews (n=42) and an electronic consultation exercise (n=39).ResultsThis study provides unique insight into the mesothelioma diagnostic experience of patients, family carers and health professionals. Key findings include the importance of regarding diagnosis as a process, and provision of continuity and consistency. The clinical nurse specialist and effective multidisciplinary team working provided vital contributions to successful mesothelioma diagnostic communication. Facilitators to diagnostic communication included honesty and timeliness in communication, partnership working and maintaining a patient-centred approach. Challenges to enhancing mesothelioma diagnosis communication included accessing ongoing training, ensuring a suitable clinical environment and being able to allocate appropriate time.ConclusionThe RADIO Meso study highlights factors that influence the communication of a diagnosis of MPM from the perspectives of individual patients and family carers. These findings provide the basis for a set of recommendations that can be used by health professionals to improve the MPM diagnostic experience.
Timing and Relevance of Clinical Improvement After Mechanical Thrombectomy in Patients With Acute Ischemic Stroke
Authors: Rudilosso Salvatore , Urra Xabier , Amaro Sergio , Llull Laura , Renú Arturo , Laredo Carlos , Obach Victor , Chamorro Ángel 
Published: May 2019

Background and Purpose—
The clinical course in patients with ischemic stroke treated with mechanical thrombectomy (MT) is heterogeneous. We aimed to study the relevance of the timing of clinical improvement in the prediction of long-term outcome in patients treated with MT.

Methods—
We studied a cohort of 423 patients with anterior circulation stroke treated with MT, of whom 334 patients (79.0%) achieved good outcome (modified Rankin Scale score of 0–2 at 90-day follow-up). National Institutes of Health Stroke Scale scores were assessed before MT, at the end of MT (d0), at day 1 (d1), and at day 7 or discharge (d7). We explored the predictive value for good outcome of different cutoffs based on absolute and percentage changes in the National Institutes of Health Stroke Scale at each assessment (d0, d1, and d7) and selected the corresponding most informative cutoffs to define substantial clinical improvement (SCI) over time. Then, we classified patients in SCI subgroups according to the delay from MT to SCI (SCI-d0, SCI-d1, and SCI-d7) and analyzed their adjusted odds ratio for good outcome compared with patients not presenting SCI (no-SCI). Additionally, we identified the independent factors predicting SCI-d0 in multivariate models.

Results—
The most informative cutoffs were 30% at d0, 40% at d1, and 70% at d7. The adjusted odds ratios (95% CI) for good outcome were 47.4 (22.1–101.7, n=172) for SCI-d0, 27.7 (11.8–65.0, n=76) for SCI-d1, and 12.6 for SCI-d7 (95% CI, 3.8–41.4, n=17) compared with no-SCI (n=158). The independent factors predicting SCI-d0 were successful reperfusion (odds ratio, 25.79; 95% CI, 12.92–51.47) and shorter time to treatment (odds ratio per hour 0.90; 95% CI, 0.85–0.96).

Conclusions—
Shorter delay to clinical improvement is strongly related to better chances of a long-term good outcome, and an improvement >30% in National Institutes of Health Stroke Scale score at the end of MT represents a reliable prognostic marker for clinicians and also for clinical research.
Primate cognition test battery in parrots
Authors: Krasheninnikova Anastasia , Berardi Roberta , Lind Mari-Ann , O’Neill Laurie , von Bayern Auguste M.P. 
Published: May 2019

AbstractSystematic, broad phylogenetic comparisons of diverse cognitive abilities are essential to understand cognitive evolution. Few studies have examined multiple skills comparatively, using identical tasks across species. Previous research centered on primates, but recent evidence suggests that complex cognition may have evolved in distantly related taxa. We administered the tasks of the primate cognition test battery (PCTB) to 4 parrot species for a first direct comparison with primates. The parrots did not perform significantly worse than the previously tested primates in all but one of the test scales, but remained at chance levels throughout. Chimpanzees outperformed them in the physical but not the social domain. No differences between the domains nor across the parrot species were detected. It remains questionable whether the chance level performance reflects the parrots’ cognitive capacity or results from task constraints, which would limit the suitability of PCTB for phylogenetic comparisons. Possible implications for the field are discussed.
Morphological and molecular characterisation of Chitwoodius coffeae sp. n. (Dorylaimida: Tylencholaimidae) from Vietnam, with a revised taxonomy of the genus
Authors: Hoang Ha , Chu Hoang Ha , Nguyen Thi Anh Duong , Trinh Quang Phap , Abolafia Joaquín , Peña-Santiago Reyes 
Published: May 2019

Summary
Chitwoodius coffeae sp. n. is described, including SEM observations and molecular (D2-D3 expansion segment of the rDNA 28S) analysis, from a coffee plantation in the Central Highlands of Vietnam. The new species is characterised by its 1.69-2.01 mm long body in females and 1.29-1.51 mm in males, lip region offset by deep constriction and 15-17 μm broad, odontostyle 27-30 μm long, neck 340-473 μm long, pharyngeal expansion occupying 52-54% of total neck length, uterus a simple tube-like structure 68-106 μm long, vulva longitudinal (V = 54-59), tail short and rounded conoid (20-28 μm, c = 54-88, c′ = 0.6-0.8) with a nearly terminal projection of inner cuticle layer, spicules 60-64 μm long, and 7-10 spaced ventromedian supplements without hiatus. SEM pictures, available for the first time for a representative of the genus, show a hexagonal (nearly hexastellate) oral field divided into six sectors by the existence of six deep incisures. Molecular analyses, also presented for the first time for a representative of the genus, results in a narrow evolutionary relationship among Chitwoodius and Tylencholaimus, and supports the monophyly of the Tylencholaimidae. This is the first record of Chitwoodius in Asian Far East territories. Chitwoodius ahmadi sp. n. is proposed for a misattributed population of C. seshadrii.
Evaluation of soybean cultivars for their susceptibility to root-lesion nematodes under temperate conditions
Authors: Elhady Ahmed , Thünen Torsten , Höppner Frank , Balko Christiane , Heuer Holger , Hallmann Johannes 
Published: May 2019

Summary
Soybean, Glycine max, is a relatively new crop in Europe gaining increasing interest for its potential to fix atmospheric nitrogen and thus increase sustainability of modern agricultural production systems. Under temperate conditions, root-lesion nematodes (Pratylenchus spp.) are one of the most prominent plant-parasitic nematode taxa of economic concern in soybean. Here, we investigated the susceptibility of soybean cultivars towards naturally occurring populations of Pratylenchus spp. and their effects on soybean yield. At the site Bundesallee the cultivars ‘Abelina’, ‘Primus’ and ‘Taifun3’ supported the highest infestation and multiplication of a mixed population of P. neglectus and P. crenatus, while ‘Sultana’ and ‘Solena’ were least susceptible. At the field site Groß Lüsewitz, ‘Primus’ and ‘Merlin’ cultivars were significantly more susceptible to P. neglectus than ‘Sultana’. Soybean yield was reduced by high initial densities of Pratylenchus spp. Results are expected to contribute to a better nematode management.
Description of Bursaphelenchus irokophilus n. sp. (Nematoda: Aphelenchoididae) isolated from Milicia excelsa (Welw.) C.C. Berg wood imported into Italy from Cameroon
Authors: Torrini Giulia , Strangi Agostino , Mazza Giuseppe , Marianelli Leonardo , Roversi Pio Federico , Kanzaki Natsumi 
Published: May 2019

Summary
A new species of Bursaphelenchus, extracted from unprocessed logs of Milicia excelsa from Cameroon and arriving in the port of Leghorn, Tuscany, Central Italy, is described. Bursaphelenchus irokophilus n. sp. is based upon morphological and molecular characters and is characterised by the two-lined lateral field, mitten-shaped spicule possessing cucullus and well-developed and slightly dorsally curved condylus with narrowly rounded tip, female vulva with side flap, and long, smoothly tapering and strongly ventrally recurved female tail. The new species belongs to the abietinus-group and is similar to, but distinguished from, B. abietinus and B. rainulfi by the position of secretory-excretory pore, longer and slender female tail and some morphometric values. In addition, the phylogeny based on SSU and D2-D3 LSU regions shows that this species belongs to the abietinus-group, the relationship among the species of this group being discussed.
The Interconnectedness of Digitalisation and Human Security in the European High North: Cybersecurity Conceptualised through the Human Security Lens
Authors: Zojer Gerald 
Published: May 2019

Digitalisation has increased rapidly in recent decades, and became integral part of the development agenda of most states. The development of cyberspace has led to numerous opportunities for human development, but it also has presented certain challenges to societies. In acknowledging the importance of digital technologies, many states have endorsed strategies for digital development and cybersecurity. Because these strategies are often state-centric, techno-deterministic, and simplistic, they disregard the interconnectedness and complexity of the opportunities and challenges these technologies can entail in a region-specific context.
This paper argues that the human security framework may be applied to analyse and study the region-specific implications of digitalisation. The multidimensional and comprehensive human security approach includes state-centric concerns as well as the needs and fears of people and communities in a specific region. Moreover, the human security framework enables the local population to voice their concerns. The insights that the human security approach offers could contribute to developing meaningful and targeted policies that address the concerns of people and communities in specific regions. The paper uses the argument on the European High North as a case study to show that digitalisation has region specific impacts and how digitalisation is interrelated with human security.
Differences in Emotion Recognition From Body and Face Cues Between Deaf and Hearing Individuals
Authors: Ferrari Chiara , Papagno Costanza , Todorov Alexander , Cattaneo Zaira 
Published: May 2019

Abstract
Deaf individuals may compensate for the lack of the auditory input by showing enhanced capacities in certain visual tasks. Here we assessed whether this also applies to recognition of emotions expressed by bodily and facial cues. In Experiment 1, we compared deaf participants and hearing controls in a task measuring recognition of the six basic emotions expressed by actors in a series of video-clips in which either the face, the body, or both the face and body were visible. In Experiment 2, we measured the weight of body and face cues in conveying emotional information when intense genuine emotions are expressed, a situation in which face expressions alone may have ambiguous valence. We found that deaf individuals were better at identifying disgust and fear from body cues (Experiment 1) and in integrating face and body cues in case of intense negative genuine emotions (Experiment 2). Our findings support the capacity of deaf individuals to compensate for the lack of the auditory input enhancing perceptual and attentional capacities in the spared modalities, showing that this capacity extends to the affective domain.
Taste the Bass: Low Frequencies Increase the Perception of Body and Aromatic Intensity in Red Wine
Authors: Burzynska Jo , Wang Qian Janice , Spence Charles , Bastian Susan Elaine Putnam 
Published: May 2019

Abstract
Associations between heaviness and bass/low-pitched sounds reverberate throughout music, philosophy, literature, and language. Given that recent research into the field of cross-modal correspondences has revealed a number of robust relationships between sound and flavour, this exploratory study was designed to investigate the effects of lower frequency sound (10 Hz to 200 Hz) on the perception of the mouthfeel character of palate weight/body. This is supported by an overview of relevant cross-modal studies and cultural production. Wines were the tastants — a New Zealand Pinot Noir and a Spanish Garnacha — which were tasted in silence and with a 100 Hz (bass) and a higher 1000 Hz sine wave tone. Aromatic intensity was included as an additional character given suggestions that pitch may influence the perception of aromas, which might presumably affect the perception of wine body. Intensity of acidity and liking were also evaluated. The results revealed that the Pinot Noir wine was rated as significantly fuller-bodied when tasted with a bass frequency than in silence or with a higher frequency sound. The low frequency stimulus also resulted in the Garnacha wine being rated as significantly more aromatically intense than when tasted in the presence of the higher frequency auditory stimulus. Acidity was rated considerably higher with the higher frequency in both wines by those with high wine familiarity and the Pinot Noir significantly better liked than the Garnacha. Possible reasons as to why the tones used in this study affected perception of the two wines differently are discussed. Practical application of the findings are also proposed.
A new Canariella species (Gastropoda: Helicoidea: Hygromiidae) of the new subgenus Majorata, both endemic to the Jandía Peninsula (Fuerteventura, Canary Islands)
Authors: ALONSO MARÍA R. , PONTE-LIRA CARMEN E. , CASTILLO CAROLINA , YANES YURENA , GROH KLAUS , IBÁÑEZ MIGUEL 
Published: May 2019

Canariella jandiaensis sp. nov. and Canariella (Majorata) subgen. nov. are described from the Jandía Peninsula mountains (Fuerteventura Island). The new subgenus, which includes C. jandiaensis and C. eutropis, is characterized mainly by the following synapomorphies: The shell is without hairs and there is a large penial papilla present arising from all the five epiphallar folds. C. jandiaensis differs from C. eutropis in the unkeeled, almost globular shell, which is smaller but taller than that of C. eutropis and has more numerous but smoother radial ribs. Also, C. jandiaensis has a pseudopapilla in the distal penial cavity instead of the thick longitudinal pilaster present in C. eutropis. The range of Majorata is small, declining from 30,000 years ago and the new species should be classified as “Critically Endangered” based on the very small size of its distribution area (smaller than 1 km2) and the very abundant and free-range livestock present. Mainly goats, grazing freely destroy the habitat in the entire Jandía mountains. Protection of their habitat is recommended, mainly by means of strict livestock control.
Hope and despair: patients’ experiences of being ineligible for transcatheter aortic valve implantation
Authors: Olsson Karin , Näslund Ulf , Nilsson Johan , Hörnsten Åsa 
Published: May 2019

Background:Transcatheter aortic valve implantation may be indicated for patients with aortic stenosis and high risk of postoperative mortality. The assessment of suitability for transcatheter aortic valve implantation requires consensus agreement of a team of cardiologists and cardiac surgeons. The burden of comorbidities, frailty and cognitive impairment are factors included when risks for transcatheter aortic valve implantation are balanced against the expected benefits. Although transcatheter aortic valve implantation is a possibility for many, there are still ineligible patients. Knowledge of their experiences of being deemed ineligible are lacking.Aim:The aim of this study was to explore patients’ experiences of being considered for transcatheter aortic valve implantation but judged ineligible.Methods:Individual in-depth interviews were performed with eight persons, and qualitative content analysis was used for the analysis.Results:Being ineligible for transcatheter aortic valve implantation may induce both hope and despair. Hope was linked to experiences of acceptance, relief of symptoms, support and control; despair was associated with feelings of being missed and abandoned, and of grief and insecurity. Some expressed great anxiety, since their incurable heart disease meant an imminent death. Others were more concerned over practical problems that affected everyday life.Conclusion:Being ineligible for transcatheter aortic valve implantation does not necessarily lead to despair. Hope is built through relationships, continuity and support. A combination of person-centred care and palliative care during the end-of-life phase should be offered to patients in order to help clients re-conceptualise hope during this stage of their illness. Cardiovascular nurses in the transcatheter aortic valve implantation team are suitable to facilitate continued care based on the patient’s needs, desires and local conditions.
R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma
Authors: Ferreri Andrés J. M. , Calimeri Teresa , Conte Gian Marco , Cattaneo Dario , Fallanca Federico , Ponzoni Maurilio , Scarano Eloise , Curnis Flavio , Nonis Alessandro , Lopedote Paolo , Citterio Giovanni , Politi Letterio S. , Foppoli Marco , Girlanda Stefania , Sassone Marianna , Perrone Salvatore , Cecchetti Caterina , Ciceri Fabio , Bordignon Claudio , Corti Angelo , Anzalone Nicoletta 
Published: May 2019

AbstractPatients with primary central nervous system lymphoma (PCNSL) are treated with high-dose methotrexate-based chemotherapy, which requires hospitalization and extensive expertise to manage related toxicity. The use of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) could overcome these difficulties, but blood-brain barrier (BBB) penetration of related drugs is poor. Tumor necrosis factor-α coupled with NGR (NGR-hTNF), a peptide targeting CD13+ vessels, induces endothelial permeabilization and improves tumor access of cytostatics. We tested the hypothesis that NGR-hTNF can break the BBB, thereby improving penetration and activity of R-CHOP in patients with relapsed/refractory PCNSL (NCT03536039). Patients received six R-CHOP21 courses, alone at the first course and preceded by NGR-hTNF (0.8 μg/m2) afterward. This trial included 2 phases: an “explorative phase” addressing the effect of NGR-hTNF on drug pharmacokinetic parameters and on vessel permeability, assessed by dynamic contrast-enhanced magnetic resonance imaging and 99mTc-diethylene-triamine-pentacetic acid–single-photon emission computed tomography, and the expression of CD13 on tumor tissue; and an “expansion phase” with overall response rate as the primary end point, in which the 2-stage Simon Minimax design was used. At the first stage, if ≥4 responses were observed among 12 patients, the study accrual would have continued (sample size, 28). Herein, we report results of the explorative phase and the first-stage analysis (n = 12). CD13 was expressed in tumor vessels of all cases. NGR-hTNF selectively increased vascular permeability in tumoral/peritumoral areas, without interfering with drug plasma/cerebrospinal fluid concentrations. The NGR-hTNF/R-CHOP combination was well tolerated: there were only 2 serious adverse events, and grade 4 toxicity was almost exclusively hematological, which were resolved without dose reductions or interruptions. NGR-hTNF/R-CHOP was active, with 9 confirmed responses (75%; 95% confidence interval, 51-99), 8 of which were complete. In conclusion, NGR-hTNF/R-CHOP was safe in these heavily pretreated patients. NGR-hTNF enhanced vascular permeability specifically in tumoral/peritumoral areas, which resulted in fast and sustained responses.