bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study
Authors: Ntlholang Ontefetse , McCarroll Kevin , Laird Eamon , Molloy Anne M. , Ward Mary , McNulty Helene , Hoey Leane , Hughes Catherine F. , Strain J. J. , Casey Miriam , Cunningham Conal 
Published: July 2018

AbstractPrevious reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multi-variable linear regression models were used to assess the association between adiposity and cognitive function adjusting for insulin resistance, inflammation and cerebrovascular disease. The mean ages were 80·3 (sd6·7), 71·0 (sd7·3) and 70·2 (sd6·3) years on the cognitive, bone and hypertensive cohorts, respectively. In the cognitive cohort, BMI was positively associated with immediate and delay memory, visuospatial/constructional ability, language and MMSE, and negatively with FAB (log-transformed), whereas WHR was negatively associated with attention. In the bone cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with visuospatial/constructional ability, attention and MMSE. In the hypertensive cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with immediate and delayed memory, visuospatial/constructional ability, language and MMSE and positively with FAB (log-transformed). In the cognitive and bone cohorts, the association of WHR and attention disappeared by further controlling for C-reactive protein and HbA1C. In this study of older adults, central adiposity was a stronger predictor of poor cognitive performance than BMI. Older adults could benefit from targeted public health strategies aimed at reducing obesity and obeseogenic risk factors to avoid/prevent/slow cognitive dysfunction.
Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome
Authors: Bernini Luciana J. , Simão Andréa N. Colado , de Souza Cínthia H. B. , Alfieri Daniela F. , Segura Liliane G. , Costa Giselle N. , Dichi Isaias 
Published: July 2018

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.
Energy depletion by 24-h fast leads to compensatory appetite responses compared with matched energy depletion by exercise in healthy young males
Authors: Thivel David , Finlayson Graham , Miguet Maud , Pereira Bruno , Duclos Martine , Boirie Yves , Doucet Eric , Blundell John E. , Metz Lore 
Published: July 2018

AbstractAlthough there is a growing interest for the effects of intermittent fasting on energy balance, this study aimed to compare appetite, energy intake and food reward responses with an energy depletion induced either by 24-h food restriction or an equivalent deficit with exercise in healthy males. In all, twelve healthy lean males (21·5 (sd 0·5) years old; BMI: 22·5 (sd 1·7) kg/m2) participated in this study. Body composition, aerobic capacity, food preferences and energy intake were assessed. They randomly completed three conditions: (i) no depletion (CON); (ii) full 24-h energy restrictions (Def-EI); and (iii) exercise condition (Def-EX). Ad libitum energy intake and food reward were assessed at the end of each session. Appetite feelings were assessed regularly. Ad libitum energy intake was higher on Def-EI (7330 (sd 2975) kJ (1752 (sd 711) kcal) compared with that on CON (5301 (sd 1205) kJ (1267 (sd 288) kcal)) (P<0·05), with no difference between CON and Def-EX (6238 (sd 1741) kJ (1491 (sd 416) kcal) (P=0·38) and between Def-EX and Def-EI (P=0·22). There was no difference in the percent energy ingested from macronutrients. Hunger was lower on CON and Def-EX compared with Def-EI (P<0·001). Satiety was higher on CON and Def-EI compared with that on Def-EX (P<0·001). There was a significant interaction condition × time for food choice fat bias (P=0·04), showing a greater preference for high-fat v. low-fat food during Def-EI and Def-EX. Although 24-h fasting leads to increased energy intake at the following test meal (without total daily energy intake difference), increased hunger profile and decreased post-meal food choice fat bias, such nutritional responses are not observed after a similar deficit induced by exercise.
Occurrence, diagnosis and follow-up of canine strongyloidiosis in naturally infected shelter dogs
Authors: Iatta Roberta , Buonfrate Dora , Paradies Paola , Cavalera Maria Alfonsa , Capogna Antonio , Iarussi Fabrizio , Šlapeta Jan , Giorli Giovanni , Trerotoli Paolo , Bisoffi Zeno , Otranto Domenico 
Published: July 2018

AbstractStrongyloidiosis byStrongyloides stercoralisis a disease of increasing interest in human and animal medicine. The scientific knowledge on canine strongyloidiosis is hindered by the poor diagnostics available. To assess the most sensitive and specific diagnostic method, feces and blood from 100 shelter dogs were screened forS. stercoralisby coprological, molecular and serological tests. Thirty-six dogs (36%) scored positive toS. stercoralisby coprology (22.3% to Baermann) and/or 30% to real time-polymerase chain reaction (rt-PCR). According to two composite reference standards (CRS) based on all coprological methods and rt-PCR (first CRS) or in combination with serology (second CRS), the most sensitive test was IFAT (93.8%; CI 82.8–98.7), followed by rt-PCR (80.6%; 95% CI 64–91.8) and Baermann (60.6%; 95% CI 42.1–77.1). The inconsistent shedding of L1 during the 4-week follow-up in infected dogs suggests the importance of multiple faecal collections for a reliable diagnosis. A combination of serological and coprological tests is recommended for the surveillance and diagnosis ofS. stercoralisinfection in dogs.
Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder
Authors: Xu Tingting , Zhao Qing , Wang Pei , Fan Qing , Chen Jue , Zhang Haiyin , Yang Zhi , Stein Dan J. , Wang Zhen 
Published: July 2018

AbstractBackgroundThe role of the cerebellum in obsessive-compulsive disorder (OCD) has drawn increasing attention. However, the functional connectivity between the cerebellum and the cerebral cortex has not been investigated in OCD, nor has the relationship between such functional connectivity and clinical symptoms.MethodsA total of 27 patients with OCD and 21 healthy controls (HCs) matched on age, sex and education underwent magnetic resonance imaging (MRI). Seed-based connectivity analyses were performed to examine differences in cerebellar-cerebral connectivity in patients with OCD compared with HCs. Associations between functional connectivity and clinical features in OCD were analyzed.ResultsCompared with HCs, OCD patients showed significantly decreased cerebellar-cerebral functional connectivity in executive control and emotion processing networks. Within the OCD group, decreased functional connectivity in an executive network spanning the right cerebellar Crus I and the inferior parietal lobule was positively correlated with symptom severity, and decreased connectivity in an emotion processing network spanning the left cerebellar lobule VI and the lingual gyrus was negatively correlated with illness duration.ConclusionsAltered functional connectivity between the cerebellum and cerebral networks involved in cognitive-affective processing in patients with OCD provides further evidence for the involvement of the cerebellum in the pathophysiology of OCD, and is consistent with impairment in executive control and emotion regulation in this condition.
On the ignition of small thermonuclear assemblies
Authors: Winterberg Friedwardt 
Published: July 2018

AbstractA novel way for igniting small thermonuclear assemblies by inertial confinement is proposed, by replacing the positive mass of an imploding dense star with the negative mass in the reference frame of a rapidly rotating thermonuclear target. According to Einstein's general theory of relativity, this negative mass can be orders of magnitude larger than the positive mass density of a neutron star. This novel concept also replaces the Plutonium 239 “spark plugs” of large thermonuclear devices with a shell of natural uranium surrounding a target composed of DT or Li6D.Unlike the ignition by a laser – or particle beam – induced spherical implosion, this configuration, similar to that of an imploding star is not only Rayleigh–Taylor stable, but it can be realized with intense relativistic electron or ion beams, with an energy of about 100 MJ, having a short range in the dense high Z natural uranium shell.
Relativistic effects on propagation of q-Gaussian laser beam in a rippled density plasma: Application of higher order corrections
Authors: Kaur M. , Agarwal P. C. , Kaur S. , Gill T. S. 
Published: July 2018

AbstractA nonparaxial investigation for propagation characteristics of q-Gaussian laser beam in rippled density plasma is studied by considering the relativistic nonlinearity. The field distribution in the medium is expressed in terms of q parameter and beam width parameter f. Nonlinear parabolic partial differential equation governing the evolution of complex envelope in slowly varying approximation is solved in a modulated density profile. Analytical theory of self-focusing including higher order terms in the expansion of dielectric function up to fourth order is developed and the variation of beam width parameter f with the distance of propagation for different parameters is studied. One may note that increased value of density ripple, laser intensity and depth of modulation, increases self-focusing whereas a lower value of q shows strong self-focusing. A comparative study between paraxial and nonparaxial study has also conducted. This study is useful for research in high energy density physics.
An adaptive hierarchical control for aerial manipulators
Authors: Pierri Francesco , Muscio Giuseppe , Caccavale Fabrizio 
Published: July 2018

SUMMARYThis paper addresses the trajectory tracking control problem for a quadrotor aerial vehicle, equipped with a robotic manipulator (aerial manipulator). The controller is organized in two layers: in the top layer, an inverse kinematics algorithm computes the motion references for the actuated variables; in the bottom layer, a motion control algorithm is in charge of tracking the motion references computed by the upper layer. To the purpose, a model-based control scheme is adopted, where modelling uncertainties are compensated through an adaptive term. The stability of the proposed scheme is proven by resorting to Lyapunov arguments. Finally, a simulation case study is proposed to prove the effectiveness of the approach.
Kinematic study on a self-propelled bionic underwater robot with undulation and jet propulsion modes
Authors: Xie Ou , Zhu Qixin , Shen Lin , Ren Kun 
Published: July 2018

SUMMARYThis paper proposed a novel type of bionic underwater robot (BUR). The undulation and jet propulsion modes on the self-propelled BUR were combined, and the kinematic characteristics of the two propulsion modes were thoroughly compared. First, the prototype and swimming strategy of the BUR were presented, and a dynamic model of the BUR was established based on several assumptions. Then, a central pattern generator (CPG) model allowing free adjustment of frequency and amplitude was employed to achieve the undulation propulsion of carangiform fish and the jet propulsion of jellyfish. Also, the kinematic characteristics of the two propulsion modes were investigated through experiments under different caudal fin actuation parameters. The experimental results indicate that the developed prototype can realize the undulation and jet propulsion by the means of the coordinated movement of the multi-caudal fins. By adjusting the CPG parameters, the BUR can switch the propulsion mode smoothly. Furthermore, the propulsion velocity of the BUR initially increased rapidly with the frequency and then slowed down when the frequency was greater than 0.8 Hz in both propulsion modes. The undulation propulsion velocity increased with the amplitude in the measurement ranges, however, the jet propulsion velocity initially increased quickly with the amplitude and then kept constant and even decreased when the amplitude was greater than 11 cm. Under the same caudal fin actuation parameters, the average velocity in undulation propulsion mode was higher than that in jet propulsion mode.
COSTS OF HOME-BASED TELEMEDICINE PROGRAMS: A SYSTEMATIC REVIEW
Authors: Michaud Tzeyu L. , Zhou Junmin , McCarthy Molly A. , Siahpush Mohammad , Su Dejun 
Published: July 2018

Objectives:The aim of this study was to systematically investigate existing literature on the costs of home-based telemedicine programs, and to further summarize how the costs of these telemedicine programs vary by equipment and services provided.Methods:We undertook a systematic review of related literature by searching electronic bibliographic databases and identifying studies published from January 1, 2000, to November 30, 2017. The search was restricted to studies published in English, results from adult patients, and evaluation of home telemedicine programs implemented in the United States. Summarized telemedicine costs per unit of outcome measures were reported.Results:Twelve studies were eligible for our review. The overall annual cost of providing home-based telemedicine varied substantially depending on specific chronic conditions, ranging from USD1,352 for heart failure to USD206,718 for congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and diabetes as a whole. The estimated cost per-patient-visit ranged from USD24 for cancer to USD39 for CHF, COPD, or chronic wound care.Conclusions:The costs of home-based telemedicine programs varied substantially by program components, disease type, equipment used, and services provided. All the selected studies indicated that home telemedicine programs reduced care costs, although detailed cost data were either incomplete or not presented in detail. A comprehensive analysis of the cost of home-based telemedicine programs and their determinants is still required before the cost efficiency of these programs can be better understood, which becomes crucial for these programs to be more widely adopted and reimbursed.
Pollination syndromes and interaction networks in hummingbird assemblages in El Triunfo Biosphere Reserve, Chiapas, Mexico
Authors: Partida-Lara Ruth , Enríquez Paula L. , Vázquez-Pérez José Raúl , de Bonilla Esteban Pineda-Diez , Martínez-Ico Miguel , Rangel-Salazar José L. 
Published: July 2018

Abstract:Plant–animal mutualistic interactions through ecological network systems and the environmental conditions in which they occur, allow us to understand patterns of species composition and the structure and dynamics of communities. We evaluated whether flower morphologies with different pollination syndromes (ornithophilous and non-ornithophilous) are used by hummingbirds and whether these characteristics affect the structure (core-peripheral species) of hummingbird networks. Observations were made in flowering patches, where plant–hummingbird interactions were recorded at three altitudes (300–2500 m) during three seasons (dry, rainy and post-rainy) from 2015 to 2016 at El Triunfo Biosphere Reserve, Chiapas, Mexico. We recorded 15 hummingbird species interacting with 58 plant species, and the greatest number of interacting hummingbird species (11; 14) and plant species (28; 40) were found at middle altitudes and during the dry season, respectively. In all study sites, most of the plant species visited by hummingbirds had an ornithophilous syndrome (67%) at high altitudes (22 plant species) and during the dry season (26 plant species), but more individual hummingbirds visited non-ornithophilous plant species. The hummingbird species at high altitudes exhibited the greatest level of specialization towards plants (H2′ = 0.74), but the networks of plant-hummingbird interactions were generalist (H2′ = 0.25); i.e. visiting plants with both syndromes, at low altitudes. The core generalist hummingbird species remained constant with altitude and season, but the core generalist plant species varied between different altitudes and seasons according to the phenology of the species.
Vulnerability and policy responses in the face of natural resource discoveries and climate change: introduction
Authors: Cockburn John , Henseler Martin , Maisonnave Hélène , Tiberti Luca 
Published: July 2018

AbstractThis special issue contributes to the natural resource economics literature by shining a light on the specific challenges and opportunities faced by developing countries that have recently become dependent on natural resources or are particularly exposed to climate change. It is composed of five studies on countries from all regions of the developing world, involving a variety of natural resources and policy issues. Four of the five studies illustrate how computable general equilibrium models are particularly well-suited, despite their relatively limited past use, to the analysis of natural resources. All five studies are led by researchers based in these countries, providing unique insights into the specific local context. The studies underscore the extreme vulnerability that the introduction of significant natural resource revenues and climate change can create in developing countries. They also show how the choice of appropriate policies to avoid the resource curse varies according to country-specific economic conditions.
A planning study to optimise a simultaneously integrated boost treatment of larynx cancer with seven intensity-modulated radiation therapy (IMRT) beams
Authors: Erraoudi M. , Youssoufi M. A. , Bentayeb F. , Malisan M. R. 
Published: July 2018

AbstractBackgroundIntensity-modulated radiation therapy (IMRT) is one of the most reported techniques for head and neck cancer treatment, as it allows a good coverage of the planning target volume (PTV) while sparing the surrounding organs at risk (OAR) better than conventional conformal radiotherapy. The objective of this work is to optimise an IMRT technique for the simultaneously integrated boost (SIB) treatment of larynx cancer delivering a total dose of 69·96 Gy to the boost volume and 54·45 Gy to the elective volume in 33 fractions.MethodsThree IMRT techniques, each using seven equally spaced beams, were planned for a sample of 10 patients. The first two techniques (IMRT-0 and IMRT-26) differ only for the starting angle of the seven beams, whereas the third (IMRT-CT) combines both these techniques by delivering IMRT-0 in the first half of treatment, and IMRT-26 in the second half, thus taking advantage of using 14 beams in total while using seven at a time only. The planning results were compared according to the dose coverage, homogeneity and conformity of the two PTVs, as well as to the dose to OARs, that is, spinal cord, parotids, mandible, brainstem and healthy tissue (defined as the body volume minus the sum of PTVs).ResultsBasically the PTV coverage resulted acceptable and comparable with all the three techniques. Concerning OARs, statistically better results are obtained in IMRT-CT when compared with IMRT-26 and IMRT-0.ConclusionThe IMRT-CT technique, combining two different seven-beam setups, delivered in two treatment phases, improves dose distribution without increasing delivery time.
State of advance care planning research: A descriptive overview of systematic reviews
Authors: Jimenez Geronimo , Tan Woan Shin , Virk Amrit K. , Low Chan Kee , Car Josip , Ho Andy Hau Yan 
Published: July 2018

AbstractObjectiveTo provide an overview of the current state of research of advance care planning (ACP), highlighting most studied topics, publication time, quality of studies and reported outcomes, and to identify gaps to improve ACP receptivity, utilization, implementation, and outcomes.MethodCochrane methodology for conducting overviews of systematic reviews. Study quality was assessed using a modified version of the Assessing the Methodological Quality of Systematic Reviews tool. The following databases were searched from inception to April 2017: MEDLINE, EBM Reviews, Cochrane Reviews, CINAHL, Global Health, PsycINFO, and EMBASE. Searches were supplemented with gray literature and manual searches.ResultEighty systematic reviews, covering 1,662 single articles, show that ACP-related research focuses on nine main topics: (1) ACP as part of end-of-life or palliative care interventions, (2) care decision-making; (3) communication strategies; (4) factors influencing ACP implementation; (5) ACP for specific patient groups, (6) ACP effectiveness; (7) ACP experiences; (8) ACP cost; and (9) ACP outcome measures. The majority of this research was published since 2014, its quality ranges from moderate to low, and reports on documentation, concordance, preferences, and resource utilization outcomes.Significance of resultsDespite the surge of ACP research, there are major knowledge gaps about ACP initiation, timeliness, optimal content, and impact because of the low quality and fragmentation of the available evidence. Research has mostly focused on discrete aspects within ACP instead of using a holistic evaluative approach that takes into account its intricate working mechanisms, the effects of systems and contexts, and the impacts on multilevel stakeholders. Higher quality studies and innovative interventions are needed to develop effective ACP programs and address research gaps.