bluuebunny/crossref_metadata_2025_split huggingface dataset:
ФОРМИРОВАНИЕ ЦИФРОВОЙ ГРАМОТНОСТИ КУРСАНТОВ ВОЕННЫХ ВУЗОВ В УСЛОВИЯХ ГИБРИДНОГО ОБУЧЕНИЯ
Authors: Г.С. ПАЛЬЧИКОВА 
Published: November 2024

В статье исследованы особенности формирования цифровой и графической грамотности курсантов военных учебных заведений в условиях гибридного обучения. Современное общество предъявляет высокие требования к уровню профессиональной подготовки выпускников военных высших учебных заведений. Это подразумевает необходимость их все- сторонней развитости, как в теоретическом, так и в практическом аспектах, для успешного ведения научных исследований, аналитической работы и внедрения инноваций. Для того чтобы курсанты были конкурентоспособны и способны эффективно работать в условиях ак- тивного применения современных информационных технологий, необходимо сформировать условия для формирования навыков пользования современными цифровыми системами в своей профессии. Для улучшения эффективности обучения курсантов и их подготовки к информационно-аналитической работе критически необходимо определить и применить необходимый набор организационных и педагогических мер. Целью исследования является изучение особенностей обучения курсантов графическим дисциплинам и формирование навыков цифровой грамотности в условиях применения ги- бридного типа обучения. В результате исследования произведен обзор научно-практических сведений по пред- ставленной тематике, даны авторские выводы.
The article examines the features of the formation of digital and graphic literacy of cadets of military educational institutions in the context of hybrid learning. Modern society places high demands on the level of professional training of graduates of military higher educational institutions. This implies the need for their comprehensive development, both in theoretical and practical aspects, for the successful conduct of scientific research, analytical work and the implementation of innovations. In order for cadets to be competitive and able to work effectively in the conditions of active use of modern information technologies, it is necessary to create conditions for the formation of skills in using modern digital systems in their profession. To improve the effectiveness of cadet training and their preparation for information and analytical work, it is critical to determine and apply the necessary set of organizational and pedagogical measures. The aim of the study is to examine the characteristics of teaching cadets graphic disciplines and the formation of digital literacy skills in the context of using a hybrid type of training. As a result of the study, a review of scientific and practical information on the presented topic was conducted, and the author's conclusions were given.
ПОДГОТОВКА БУДУЩИХ УЧИТЕЛЕЙ К ФОРМИРОВАНИЮ ФУНКЦИОНАЛЬНОЙ ГРАМОТНОСТИ ШКОЛЬНИКОВ: СОДЕРЖАТЕЛЬНЫЙ АСПЕКТ
Authors: А.В. ПЕРЕВОЗНЫЙ 
Published: November 2024

Проблема формирования функциональной грамотности школьников вышла на пе- редний план в последние годы, что нашло свое отражение в документах, опре- деляющих функционирование среднего общего образования. Ее решение невоз- можно без квалифицированного педагогического руководства, которое может быть получено при специальной подготовке учителей. Цель исследования состоит в том, чтобы представить содержание подготовки будущих педагогов в интересующем нас направлении в виде компетенций, овладение которыми позволит обеспечить совокупное формирова- ние у школьников различных видов функциональной грамотности. Для ее достижения были применены следующие методы исследования: анализ научной литературы и ее обобщение, наблюдение за образовательным процессом, беседа. В результате исследо- вания выделены три группы компетенций, необходимых педагогу для осуществления профессиональной деятельности, включая формирование функциональной грамотности школьников; показано, что на материале одного и того же предмета могут формироваться разные ее виды, и это требует от учителя соответствующей квалификации; на примере общепедагогических дисциплин раскрыто, какие изменения в их содержании следова- ло бы произвести, чтобы подготовить будущего учителя к формированию функциональной грамотности школьников.
The problem of the formation of functional literacy of schoolchildren has come to the fore in recent years, which is reflected in the documents that determine the functioning of secondary general education. Its solution is impossible without qualified pedagogical guidance, which can be obtained due to the appropriate training of teachers. The purpose of the study is to present the content of training of prospective teachers for formation functional literacy of pupils in the form of competencies, the mastery of which will ensure the cumulative formation of various types of functional literacy among schoolchildren. To achieve it, the following research methods were applied: analysis of the scientific literature and its generalization, observation of the educational process, conversation. As a result of the study, three groups of competencies were identified that the teacher needs to carry out professional activities, including the formation of functional literacy of schoolchildren; it is shown that different types of functional literacy can be formed on the material of the same subject, and this requires the teacher to be appropriately qualified; on the example of general pedagogical disciplines, it is revealed what changes in their content should be made in order to prepare the prospective teacher for the formation of functional literacy of schoolchildren.
Patient Satisfaction and Quality of Life Following Cosmetic Surgery: A Multicentre Cross-Sectional Study
Authors: Nayab Zahra , Azeem Hamdia , Haider Syed Farhad , Munir Sabah , Khan Danyal , Majeed Muhammad Rafay , Tahir Salman 
Published: November 2024

Background: Cosmetic surgery significantly impacts patient satisfaction and quality of life, reflecting physical and psychological outcomes. A multicenter evaluation provides insights into these dimensions across diverse populations and practices. Objectives: The purpose of the study was to evaluate postoperative changes in quality of life (physical, emotional, and social domains) and to determine demographic factors (age and gender) in the influence of these results. Methods: Study was conducted in different cosmetic surgery clinics in Lahore, were selected total of n=100 patients who had undergone cosmetic procedures in the past 6 months. Preoperatively and 3 to 6 months postoperatively, the SF-36 quality of life questionnaire was given. Changes in quality-of-life scores were assessed using paired t tests and interactions between demographics and procedure types were explored using two-way ANOVA. Predictors of improved physical functioning were identified using multiple linear regression. Results: The largest emotional well-being gains were seen with breast augmentation and rhinoplasty (47% (95% CI: 40–54%) and 41% (95% CI: 35–48%), respectively; p<0.05). Liposuction resulted in a 38% improvement in physical functioning (95% CI: 32–44%, p<0.001). Botox and dermal fillers were associated with 30% (95% CI: 24–36%, p < 0.05) and 28% (95% CI: 21–34%, p < 0.01) improvement in social functioning, respectively. Physical functioning improvement was strongest for liposuction (β = 0.45, p<0.001), while younger patients experienced greater improvements (β = -0.31, p < 0.01). Conclusion: Cosmetic procedures have significant impact on physical, emotional and social quality of life, and outcomes depend on procedure type and demographics.
DIFERENTES DOSES DE NITROGÊNIO NA CULTURA DO MOMBAÇA
Authors: Silva Kaio César do Carmo , Borges Marcos Antônio Alves , Carvalho Lucas Roberto de 
Published: November 2024

Este estudo investigou o efeito de diferentes doses de nitrogênio na cultura do Mombaça (Panicum maximum cv. Mombaça), uma gramínea utilizada amplamente na pecuária brasileira. O experimento foi conduzido no município de Edealina Goiás, durante um período de 90 dias. Foram testadas quatro doses de nitrogênio: testemunha (sem adição de nitrogênio), 100kg/ha, 200kg/ha e 400kg/ha de ureia granulada, em quatro repetições cada. A irrigação foi realizada por gotejamento ou regador, conforme necessário. Os resultados indicaram que as diferentes doses de nitrogênio tiveram impacto significativo no crescimento e na produtividade do Mombaça. A dose de 200kg/ha apresentou os melhores resultados em termos de altura das plantas, vigor e produção de biomassa. Por outro lado, doses mais elevadas (400kg/ha) não resultaram em aumentos adicionais significativos na produtividade, sugerindo uma possível saturação dos efeitos do nitrogênio. Este estudo contribui para o entendimento dos requisitos nutricionais do Mombaça e fornece informações valiosas para a otimização do manejo de fertilizantes nitrogenados nesta cultura.
Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor‐Based 3D Culture System
Authors: Manfredonia Celeste , Muraro Manuele G. , Hirt Christian , Mele Valentina , Governa Valeria , Papadimitropoulos Adam , Däster Silvio , Soysal Savas D. , Droeser Raoul A. , Mechera Robert , Oertli Daniel , Rosso Raffaele , Bolli Martin , Zettl Andreas , Terracciano Luigi M. , Spagnoli Giulio C. , Martin Ivan , Iezzi Giandomenica 
Published: March 2019

AbstractColorectal cancer (CRC) is a leading cause of cancer‐related death. Conventional chemotherapeutic regimens have limited success rates, and a major challenge for the development of novel therapies is the lack of adequate in vitro models. Nonmalignant mesenchymal and immune cells of the tumor microenvironment (TME) are known to critically affect CRC progression and drug responsiveness. However, tumor drug sensitivity is still evaluated on systems, such as cell monolayers, spheroids, or tumor xenografts, which typically neglect the original TME. Here, it is investigated whether a bioreactor‐based 3D culture system can preserve the main TME cellular components in primary CRC samples. Freshly excised CRC fragments are inserted between two collagen scaffolds in a “sandwich‐like” format and cultured under static or perfused conditions up to 3 d. Perfused cultures maintain tumor tissue architecture and densities of proliferating tumor cells to significantly higher extents than static cultures. Stromal and immune cells are also preserved and fully viable, as indicated by their responsiveness to microenvironmental stimuli. Importantly, perfusion‐based cultures prove suitable for testing the sensitivity of primary tumor cells to chemotherapies currently in use for CRC. Perfusion‐based culture of primary CRC specimens recapitulates TME key features and may allow assessment of tumor drug response in a patient‐specific context.
Microscaffolds by Direct Laser Writing for Neurite Guidance Leading to Tailor‐Made Neuronal Networks
Authors: Fendler Cornelius , Denker Christian , Harberts Jann , Bayat Parisa , Zierold Robert , Loers Gabriele , Münzenberg Markus , Blick Robert H. 
Published: March 2019

AbstractWhile modern day integrated electronic circuits are essentially designed in a 2D fashion, the brain can be regarded as a 3D circuit. The thus enhanced connectivity enables much more complex signal processing as compared to conventional 2D circuits. Recent technological advances in the development of nano/microscale 3D structuring have led to the development of artificial neuron culturing platforms, which surpass the possibilities of classical 2D cultures. In this work, in vitro culturing of neuronal networks is demonstrated by determining predefined pathways through topological and chemical neurite guiding. Tailor‐made culturing substrates of microtowers and freestanding microtubes are fabricated using direct laser writing by two‐photon polymerization. The first scaffold design that allows for site‐specific cell attachment and directed outgrowth of single neurites along defined paths that can be arranged freely in all dimensions, to build neuronal networks with low cell density, is presented. The neurons cultured in the scaffolds show characteristic electrophysiological properties of vital cells after 10 d in vitro. The introduced scaffold design offers a promising concept for future complex neuronal network studies on defined neuronal circuits with tailor‐made design specific neurite connections beyond 2D.
Off‐Stoichiometric Thiol‐Ene Chemistry to Dendritic Nanogel Therapeutics
Authors: Zhang Yuning , Andrén Oliver C. J. , Nordström Randi , Fan Yanmiao , Malmsten Martin , Mongkhontreerat Surinthra , Malkoch Michael 
Published: March 2019

AbstractA novel platform of dendritic nanogels is herein presented, capitalizing on the self‐assembly of allyl‐functional polyesters based on dendritic‐linear‐dendritic amphiphiles followed by simple cross‐linking with complementary monomeric thiols via UV initiated off‐stoichiometric thiol‐ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190–295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model.
Validation of a Vasculogenesis Microfluidic Model for Radiobiological Studies of the Human Microvasculature
Authors: Guo Zhaobin , Yang Chih‐Tsung , Maritz Michelle F. , Wu Huanjin , Wilson Puthenparampil , Warkiani Majid Ebrahimi , Chien Chia‐Chi , Kempson Ivan , Aref Amir R. , Thierry Benjamin 
Published: March 2019

AbstractThe therapeutic ratio of radiotherapy is limited by acute or chronic side effects with often severe consequences to patients. The microvasculature is a central player involved in both tumor responses and healthy tissue/organ radiological injuries. However, current preclinical vascular models based on 2D culture offer only limited radiobiological insight due to their failure in recapitulating the 3D nature experienced by endothelial cells within the human microvasculature. To address this issue, the use of a 3D microvasculature‐on‐a‐chip microfluidic technology is demonstrated in radiobiological studies. Within this vasculogenesis model a perfusable network that structurally mimics the human microvasculature is formed and the biological response to ionizing radiation including cellular apoptosis, vessel tight adherens junction breakage, DNA double strand break, and repair is systematically investigated. In comparison to cells grown in a 2D environment, human umbilical vein endothelial cells in the 3D microvasculature‐on‐a‐chip displays significant differences in biological responses, especially at high X‐ray dose. This data confirms the feasibility of using microvascular‐on‐a‐chip models for radiobiological studies. Such vasculogenesis models have strong potential to yield more accurate prediction of healthy tissue responses to ionizing radiation as well as to guide the development of risk‐reducing strategies to prevent radiation‐induced acute and long‐term side‐effects.
Efficient Synthesis of Functionalized Indene Derivatives via Rh(III)‐Catalyzed Cascade Reaction between Oxadiazoles and Allylic Alcohols
Authors: Zhang Jing , Sun Jun‐Shu , Xia Ying‐Qi , Dong Lin 
Published: March 2019

AbstractA highly efficient rhodium(III)‐catalyzed synthesis of novel functionalized indene derivatives has been achieved via C−H activation/intramolecular aldol condensation. This cascade reaction is an atom economical protocol which could be further applied to build more complex compounds.magnified image
Development of a Non‐Coding‐RNA‐based EMT/CSC Inhibitory Nanomedicine for In Vivo Treatment and Monitoring of HCC
Authors: Guo Ruomi , Wu Zhiqiang , Wang Jing , Li Qingling , Shen Shunli , Wang Weiwei , Zhou Luyao , Wang Wei , Cao Zhong , Guo Yu 
Published: March 2019

AbstractThe objective of this study is to improve the overall prognosis of patients with hepatocellular carcinoma (HCC); therefore, new therapeutic methods that can be used in vivo are urgently needed. In this study, the relationship between the quantities of microRNA (miR)‐125b‐5p in clinical specimens and clinicopathological parameters is analyzed. A folate‐conjugated nanocarrier is used to transfect miR‐125b‐5p in vivo and to observe the therapeutic effect on HCC. The inhibitory effect and mechanism of miR‐125b‐5p on hepatoma cells are also studied. Data from clinical specimens and in vitro experiments confirm that the miR‐125b‐5p quantity is negatively correlated with progression, and the target protein that regulates the epithelial–mesenchymal transition (EMT)/cancer stem cells (CSC) potential in HCC is STAT3. The miR‐125b‐5p/STAT3 axis inhibits the invasion, migration, and growth of HCC via inactivation of the wnt/β‐Catenin pathway. miR‐125b‐5p‐loaded nanomedicine effectively inhibits the EMT/CSC potential of hepatoma cells in vivo together with their magnetic resonance imaging (MRI) visualization characteristics. An HCC‐therapeutic and MRI‐visible nanomedicine platform that achieves noninvasive treatment effect monitoring and timely individualized treatment course adjustment is developed.
1D ZnSSe‐ZnSe Axial Heterostructure and its Application for Photodetectors
Authors: Mu Zeming , Zheng Qi , Liu Ruping , Malik Muhammad Wasim Iqbal , Tang Dongsheng , Zhou Weichang , Wan Qiang 
Published: March 2019

AbstractSemiconductor heterostructure nanowires (HNWs) are excellent candidates for application in compact optoelectronics devices with high performance due to the heterojunction interface effect. However, the controllable fabrication of high‐quality nano‐heterostructures is elusive. In this paper, the controllable growth and optoelectronics device application of high‐quality ZnS0.49Se0.51/ZnSe axial HNWs are reported. The as‐synthesized HNWs are straight with uniform diameter distribution of 50–100 nm. Microstructural characterization reveals single crystal and abrupt heterojunction interface in these HNWs. The micro‐photoluminescence of single component region and heterojunction zone show one and integrated two near bandgap emission of ZnS0.49Se0.51 and ZnSe, respectively, further demonstrating the abrupt heterojunction interfaces nature in the as‐grown nanowires. Moreover, photodetectors based on single HNW are fabricated and the responsivity, external quantum efficiency, response speed, and detection wavelength range are superior to that of single component nanowire photodetectors at room temperature. These results show that the ZnS0.49Se0.51/ZnSe HNWs and corresponding high‐performance photodetectors are prospective candidates for photonics and optoelectronics applications.
Lithium Dendrites Inhibition via Diffusion Enhancement
Authors: Chen Yongxiu , Dou Xiangyu , Wang Kai , Han Yongsheng 
Published: March 2019

AbstractThe dendritic structure is a disastrous problem of lithium metal batteries as well as other metal rechargeable batteries. The dendritic structures are usually caused by diffusion limitation. Here, a novel strategy is reported to inhibit lithium dendrites based on the understanding of their formation mechanism. An alternating current field perpendicular to the anode is set up, which promotes Li+movement along the anode surface and prevents ions' deposition on the tips from forming dendrites. Furthermore, an external direct current field parallel to the current is employed, which accelerates the transport of Li+in electrolytes to mitigate the concentration gradient nearby the anode and thus inhibits the formation of dendritic structures. A simultaneous employment of these two fields gains five times increase of the lifespan of batteries at the high charging current density of 2 mA cm−2, confirming the effectiveness of this strategy in protecting the metal anode and inhibiting lithium dendrites. This strategy may have a wide feasibility since it does not change the materials and structures of batteries.
Skeletal Rearrangement of Twisted Thia‐Norhexaphyrin: Multiply Annulated Polypyrrolic Aromatic Macrocycles
Authors: Li Qizhao , Ishida Masatoshi , Kai Hiroto , Gu Tingting , Li Chengjie , Li Xin , Baryshnikov Glib , Liang Xu , Zhu Weihua , Ågren Hans , Furuta Hiroyuki , Xie Yongshu 
Published: March 2019

AbstractA hybrid thia‐norhexaphyrin comprising a directly linked N‐confused pyrrole and thiophene unit (1) revealed unique macrocycle transformations to afford multiply inner‐annulated aromatic macrocycles. Oxidation with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone triggered a cleavage of the C−S bond of the thiophene unit, accompanied with skeletal rearrangement to afford unique π‐conjugated products: a thiopyrrolo‐pentaphyrin embedded with a pyrrolo[1,2]isothiazole (2), a sulfur‐free pentaphyrin incorporating an indolizine moiety (3), and a thiopyranyltriphyrinoid containing a 2H‐thiopyran unit (4). Furthermore, 2 underwent desulfurization reactions to afford a fused pentaphyrin containing a pyrrolizine moiety (5) under mild conditions. Using expanded porphyrin scaffolds, oxidative thiophene cleavage and desulfurization of the hitherto unknown N‐confused core‐modified macrocycles would be a practical approach for developing unique polypyrrolic aromatic macrocycles.
Pressure‐Induced Polymerization and Electrical Conductivity of a Polyiodide
Authors: Poręba Tomasz , Ernst Michelle , Zimmer Dominik , Macchi Piero , Casati Nicola 
Published: March 2019

AbstractWe report the high‐pressure structural characterization of an organic polyiodide salt in which a progressive addition of iodine to triiodide groups occurs. Compression leads to the initial formation of discrete heptaiodide units, followed by polymerization to a 3D anionic network. Although the structural changes appear to be continuous, the insulating salt becomes a semiconducting polymer above 10 GPa. The features of the pre‐reactive state and the polymerized state are revealed by analysis of the computed electron and energy densities. The unusually high electrical conductivity can be explained with the formation of new bonds.
Identifizierung von Chemokinliganden durch biochemische Rezeptorfragmentierung und simulierte Peptidevolution
Authors: Fuchs Jens‐Alexander , Brunner Cyrill , Schineis Philipp , Hiss Jan A. , Schneider Gisbert 
Published: March 2019

AbstractKurzkettige Peptide können gewisse Nachteile niedermolekularer Inhibitoren von Protein‐Protein‐Interaktionen (PPIs) überwinden. Wir untersuchten die Interaktion zwischen dem humanen Chemokin CCL19 und dem Chemokinrezeptor CCR7, um rezeptorabgeleitete CCL19‐bindende Peptide zu entwerfen. Die Identifizierung einer linearen Bindestelle von CCR7 und der nachfolgende Pharmakophor‐ und Lipophilie‐basierte Entwurf von computergenerierten Peptidbibliotheken führten zu fünf Hexapeptiden mit Affinitäten zu CCL19 im niedrigen mikro‐ bis nanomolaren Bereich. Dieses Ergebnis bestätigt die Anwendbarkeit des Computerverfahrens zur Findung von Peptid‐PPI‐Liganden.