bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative development and growth of Aedes albopictus in response to native Quercus rubra and invasive Lonicera maackii leaf litter
Authors: Russo Leslie K. , Boyd Jennifer N. 
Published: July 2018

1. Invasive plant species can modify native habitats in ways that influence co‐occurring mosquito populations. This study investigated the comparative influence on invasive Aedes albopictus Skuse (Asian tiger mosquito) of leaf litter of invasive Lonicera maackii (Rupr.) Maxim. (Amur honeysuckle) and leaf litter of native Quercus rubra L. (red oak).2. Two density treatment levels of A. albopictus larvae were reared in either L. maackii or Q. rubru leaf infusions in small containers in a laboratory. The success of and time to pupation and emergence, adult sex ratio, and wing length as a proxy for size were assessed as dependent variables.3. Individuals were more likely to pupate and emerge when reared in the Q. rubra infusion, but pupation occurred faster and adults grew larger when larval development occurred in the L. maackii infusion. The time to pupation for both females and males and male adult size were negatively impacted by density in the Q. rubra infusion, but density did not impact these factors in the L. maackii infusion.4. Findings suggest that A. albopictus invasion could be influenced by concurrent L. maackii invasion. However, overall impacts on A. albopictus population dynamics through time could be complex, giving the contrasting influences of L. maackii on the early survival and subsequent development and growth of A. albopictus.
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with septic shock: A case report
Authors: Kamio Masaki , Nagata Chikako , Sameshima Hirotsugu , Togami Shinichi , Kobayashi Hiroaki 
Published: July 2018

AbstractObstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a rare complex of structural abnormalities of the female urogenital tract. A nulliparous 37‐year‐old woman was referred to our department for an acute abdomen. Multiple uterine myomas and painful right vaginal bulge were found on gynecological examination. Transvaginal ultrasonography revealed a cystic mass and a right‐side cervix that was hidden behind the longitudinal vaginal septum. For these findings, pyocolpos arising from OHVIRA syndrome was suspected. Her general condition gradually worsened within an hour, and she developed septic shock and was hospitalized in the intensive care unit (ICU). Laboratory data revealed disseminated intravascular coagulation (DIC) and multiple organ failure. Her general condition gradually improved as a result of intensive care and transvaginal puncture drainage of the abscess. Hysterectomy, performed 2 months after the acute septic episode, confirmed the diagnosis of septate uterus with obstructed hemivagina. To date, there is no documented case of OHVIRA syndrome with an eventual septic shock.
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
Authors: Jankovic Sandra , Tsakiridou Georgia , Ditzinger Felix , Koehl Niklas J , Price Daniel J , Ilie Alexandra-Roxana , Kalantzi Lida , Kimpe Kristof , Holm René , Nair Anita , Griffin Brendan , Saal Christoph , Kuentz Martin 
Published: July 2018

Abstract

Objectives
Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water-soluble drugs.

Key findings
An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid-based delivery, solid dispersions and nano- or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug.

Summary
In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early-stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour-intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.
Women's perspectives on home‐based care for family members with chronic illness: An Interpretive phenomenology study
Authors: Arpanantikul Manee 
Published: July 2018

AbstractThe number of people with chronic illness who need home‐based care is increasing globally. Home‐based care is socially constructed to be work carried out by women. However, little attention has been paid to the opinions of middle‐aged women caring for family members with chronic illness at home. In this study, Thai women's perspectives on home‐based care for family members with chronic illness using interpretive phenomenology were identified. Fifteen middle‐aged women were interviewed twice, and the data were analyzed using thematic analysis. Four major themes emerged: (i) role obligation; (ii) social life change; (iii) doing good things; and (iv) lack of support. Important findings were that care was considered a woman's duty owing to cultural beliefs. Most participants sacrificed their own needs to care for others, as doing good things is considered an important Buddhist belief. Caring for others decreased women's social networks, but they cared more for their own health. Support with finances, information, workplaces, and care recipients should be provided to women with care responsibilities. These results can help nurses to better understand women's caring roles and the consequences of home‐based care that influence woman's health.
Photodynamic Therapy in HeLa Cells Incubated with Riboflavin and Pectin‐coated Silver Nanoparticles
Authors: Rivas Aiello María Belén , Castrogiovanni Daniel , Parisi Julieta , Azcárate Julio C. , García Einschlag Fernando S. , Gensch Thomas , Bosio Gabriela N. , Mártire Daniel O. 
Published: July 2018

AbstractRiboflavin (Rf) is an endogenous photosensitizer, which can participate in Type I and Type II processes. We have recently shown that the yield of the triplet excited states of Rf is enhanced in the presence of pectin‐coated silver nanoparticles (Pec@AgNP) due to formation of a complex between Rf and Pec@AgNP (Rf‐Pec@AgNP). Consequently, under aerobic conditions, the amounts of singlet molecular oxygen and superoxide radical anion generated are also larger in the presence of the nanoparticles. This result made us suspect that the nanoparticles could have a beneficial effect in Rf‐based PDT. To prove this hypothesis, we here compared the photodamage in HeLa cells incubated with Rf in the presence and in the absence of Pec@AgNP applying several optical assays. We used fluorescence imaging of irradiated HeLa cells incubated with Annexin V and propidium iodide to evaluate the occurrence of apoptosis/necrosis, the reduction of the tetrazolium dye MTT to formazan and neutral red uptake to prove cell viability, as well as synchrotron infrared microscopy of single cells to evaluate possible structural changes of DNA and nuclear proteins. The enhanced photodamage observed in the presence of Pec@AgNP seems to indicate that Rf enters into the cells complexed with the nanoparticles.
3.0 Tesla magnetic resonance imaging anatomy of the central nervous system, eye, and inner ear in birds of prey
Authors: Stańczyk Ewa K. , Velasco Gallego María L. , Nowak Maricn , Hatt Jean‐Michel , Kircher Patrick R. , Carrera Inés 
Published: July 2018

AbstractDespite the increasing interest in the clinical neurology of birds, little is known about the magnetic resonance imaging (MRI) appearance of the avian central nervous system, eye, and inner ear. The objective of this cadaveric study was to document the MRI anatomic features of the aforementioned structures using a high‐resolution 3.0 Tesla MRI system. The final study group consisted of 13 cadavers of the diurnal birds of prey belonging to six species. Images were acquired in sagittal, dorsal, and transverse planes using T1‐weighted and T2‐weighted turbo spin echo sequences. A necropsy with macroscopic analysis of the brain and spinal cord was performed on all cadavers. Microscopic examination of the brain was performed on one cadaver of each species; the spinal cord was examined in three subjects. Anatomic structures were identified on the magnetic resonance images based on histologic slices and available literature. Very good resolution of anatomic detail was obtained. The olfactory bulbs; cerebral hemispheres; diencephalon; optic lobe; cerebellum; pons; ventricular system; optic, trigeminal, and facial nerves; pineal and pituitary glands; as well as the semicircular canals of the inner ear were identified. Exquisite detail was achieved on the ocular structures. In the spinal cord, the gray and white matter differentiation and the glycogen body were identified. This study establishes normal MRI anatomy of the central nervous system, eye, and inner ear of the birds of prey; and may be used as a reference in the assessment of neurologic disorders or visual impairment in this group of birds.
Protocol of the randomised placebo controlled pilot trial of the management of acute sciatica (SCIATICA): a feasibility study
Authors: Lassere Marissa Nichole , Johnson Kent Robert , Thom Jeanette , Pickard Grant , Smerdely Peter 
Published: July 2018

IntroductionAcute sciatica (symptom duration less than 4 weeks), a major cause of pain and disability, is a common presentation to medical practices and hospital emergency departments. Selective CT fluoroscopy transforaminal epidural steroid injection is often used with the hope of reducing pain and improving function. Recently, there has been interest in using systemic corticosteroids in acute sciatica. However, there is limited evidence to inform management of selective CT fluoroscopy transforaminal epidural steroid in subacute and chronic sciatica and there is no evidence in acute sciatica, even though the practice is widespread. There is also limited evidence for the use of systemic corticosteroids in acute sciatica. Furthermore, the management of selective CT fluoroscopy transforaminal epidural steroid versus systemic steroids has never been directly studied.Methods and analysisSCIATICA is a pilot/feasibility study of patients with acute sciatica designed to evaluate the feasibility of undertaking a blinded four-arm randomised controlled intervention study of (1) selective CT fluoroscopy transforaminal epidural steroid (arm 1), (2) selective CT fluoroscopy transforaminal epidural saline (arm 2), (3) 15 days tapering dose of oral steroids (arm 3) and (4) a sham epidural and oral placebo control (arm 4). This feasibility study is designed to evaluate head-to-head, route versus pharmacology of interventions. The primary outcome measure is the Oswestry Disability Index (ODI) at 3 weeks. Secondary outcome is the ODI at 48 weeks. Other outcomes include numerical rating scale for leg pain, Pain DETECT Questionnaire, quality of life, medication use, rescue procedures or surgery, and adverse events. Results of outcomes from this randomised controlled trial will be used to determine the feasibility, sample size and power calculations for a large multicentre study.Ethics and disseminationThe study has been approved by South Eastern Sydney Local Health District Human Research Ethics Committee (HREC/15/331/POHW/586).Trial registration numberNCT03240783; Pre-results.
Rationale and design of the improving Care for Cardiovascular Disease in China (CCC) project: a national registry to improve management of atrial fibrillation
Authors: Hao Yongchen , Liu Jing , Smith Sidney C , Huo Yong , Fonarow Gregg C , Ge Junbo , Liu Jun , Taubert Kathryn A , Morgan Louise , Guo Yang , Zhou Mengge , Zhao Dong , Ma Changsheng 
Published: July 2018

IntroductionInadequate management of patients with atrial fibrillation (AF) has been reported in China for anticoagulation therapy and treatment for concomitant diseases. An effective quality improvement programme has been lacking to promote the use of evidence-based treatments and improve outcome in patients with AF.Methods and analysisThe Improving Care for Cardiovascular Disease in China-AF programme is a collaboration of the American Heart Association and the Chinese Society of Cardiology. This programme is designed to promote adherence to AF guideline recommendations and outcomes for inpatients with AF. Launched in February 2015, 150 hospitals are recruited by geographic-economic regions across 30 provinces in China. Each month, 10–20 inpatients with AF are enrolled in each hospital. A web-based data collection platform is used to collect clinical information for patients with AF, including patients’ demographics, admission information, medical history, in-hospital care and outcomes, and discharge medications for managing AF. The quality improvement initiative includes monthly benchmarked reports on hospital quality, training sessions, regular webinars and recognitions of hospital quality achievement. Primary analyses will include adherence to performance measures and guidelines. To address intrahospital correlation, generalised estimating equation models will be applied. As of March 2017, 28 801 AF inpatients have been enrolled.Ethics and disseminationThis study protocol was approved by the Ethics Committee of Beijing Anzhen Hospital, Capital Medical University. Results will be published in peer-reviewed medical journals.Trial registration numberNCT02309398.
Who is coaching the coach? Knowledge of depression and attitudes toward continuing education in coaches
Authors: Hegarty Erin M , Weight Erianne , Register-Mihalik Johna K 
Published: July 2018

BackgroundThe rate of depression among collegiate athletes ranges from 16% to 23%, with particularly high findings of prevalence in track and field athletes (34%). Collegiate athletes have also been found to underuse mental health resources. Given this high prevalence of depression and demonstrated reluctance to seek help, it is important to explore the awareness and understanding of depression among the individuals who work most closely with this population.ObjectiveTo assess coaches’ knowledge and awareness of depression among their athletes and describe their level of interest in receiving continuing education.MethodAll National Collegiate Athletic Association Division I cross-country and track and field coaches were invited to participate in an online survey. The sample consisted of 253 participants, of whom 56 (25%) identified themselves as female and 170 (75%) as male with 14 (±10.4) years of coaching experience. Respondents completed the Adolescent Depression Awareness Program (ADAP) questionnaire and related questions. Differences in depression knowledge and interest in continuing education were calculated by gender, event specialty, length of coaching experience and certification history using analysis of variance and χ2analysis.ResultsThe mean score on the ADAP depression questionnaire was 83%. Significant differences were not observed by gender, length of coaching experience, coaching title or certification history. Distance coaches scored significantly higher on the test than sprints coaches. Coaches estimated that 11% of their former and current student-athletes have struggled with depression. 77% of coaches indicated a ‘strong interest’ in receiving continuing education.ConclusionsThe findings of this study indicate the participating coaches have a goodknowledge of depressionfor individuals without formal education on the topic but may lack depressionawareness. This hypothesis is supported by the finding that coaches in the sample found out an athlete was suffering from depression most often by the athlete self-reporting.
Atrial secretion of ANP is suppressed in renovascular hypertension: shifting of ANP secretion from atria to the left ventricle
Authors: Tan Rui , Ahn You Mee , Kim Hye Yoom , Lee Yun Jung , Cho Kyung Woo , Kang Dae Gill , Lee Ho Sub 
Published: July 2018

In the present study, the change in secretion of atrial natriuretic peptide (ANP) from the atria was defined in hypertension accompanied by ventricular hypertrophy and increased synthesis of ANP. To identify the change of the secretion and mechanisms involved, experiments were performed in isolated perfused beating atria from sham-operated normotensive and renovascular hypertensive rats. Expression of ANP, natriuretic peptide receptor (NPR)-C, components of the renin-angiotensin system, and muscarinic signaling pathway was measured in cardiac tissues. Basal levels of ANP secretion and acetylcholine (ACh)- and stretch-induced activation of ANP secretion were suppressed in the atria from hypertensive compared with normotensive rats. ACh increased ANP secretion via M2 muscarinic ACh receptor-ACh-sensitive K+ channel signaling. In hypertensive rats, ANP concentration increased in the left ventricle but decreased in the right ventricle. The atrial concentration of ANP was not changed in hypertensive compared with normotensive rats. ANP mRNA expression was accentuated in the left ventricle but suppressed in the other cardiac chambers in the hearts of hypertensive rats. NPR-C expression was inversely related to ANP mRNA levels. Angiotensin II type 1 receptor (AT1R) expression was accentuated in the cardiac chambers from hypertensive rats compared with normotensive rats, whereas angiotensin II type 2 receptor, M2 muscarinic receptor, and Kir3.4 channels were suppressed. AT1R blockade with losartan reversed the change observed in hypertensive rats. The present findings indicate that renovascular hypertension shifts the major site of ANP secretion and synthesis from the atria to the left ventricle through modulation of the expression of ANP, NPR-C, AT1R, and the M2 muscarinic signaling pathway. NEW & NOTEWORTHY Renovascular hypertension suppresses the atrial secretion of ANP and shifts the major site of the regulation of ANP secretion and synthesis from atria to the hypertrophied left ventricle possibly via modulation of the expression of ANP, natriuretic peptide receptor-C, angiotensin II subtype 1 receptor, and M2 muscarinic signaling pathway.
Forestalling BRAF-Inhibitor Resistance in a Shocking Way
Authors: Sullivan Ryan J. 
Published: July 2018

Abstract
Targeting BRAF in BRAF-mutant melanoma is highly effective, but most patients develop resistance. HSP90 has been implicated and identified as a therapeutic target. Ultimately, early-stage clinical investigation will be necessary to provide proof of principle of this approach and if appropriate randomized trials to confirm promising findings. Clin Cancer Res; 24(22); 5496–8. ©2018 AACR.
See related article by Eroglu et al., p. 5516
Siglec-6 on Chronic Lymphocytic Leukemia Cells Is a Target for Post-Allogeneic Hematopoietic Stem Cell Transplantation Antibodies
Authors: Chang Jing , Peng Haiyong , Shaffer Brian C. , Baskar Sivasubramanian , Wecken Ina C. , Cyr Matthew G. , Martinez Gustavo J. , Soden Jo , Freeth Jim , Wiestner Adrian , Rader Christoph 
Published: July 2018

Abstract
Although the 5-year survival rate of chronic lymphocytic leukemia (CLL) patients has risen to &gt;80%, the only potentially curative treatment is allogeneic hematopoietic stem cell transplantation (alloHSCT). To identify possible new monoclonal antibody (mAb) drugs and targets for CLL, we previously developed a phage display–based human mAb platform to mine the antibody repertoire of patients who responded to alloHSCT. We had selected a group of highly homologous post-alloHSCT mAbs that bound to an unknown CLL cell surface antigen. Here, we show through next-generation sequencing of cDNAs encoding variable heavy-chain domains that these mAbs had a relative abundance of ∼0.1% in the post-alloHSCT antibody repertoire and were enriched ∼1,000-fold after three rounds of selection on primary CLL cells. Based on differential RNA-seq and a cell microarray screening technology for discovering human cell surface antigens, we now identify their antigen as Siglec-6. We verified this finding by flow cytometry, ELISA, siRNA knockdown, and surface plasmon resonance. Siglec-6 was broadly expressed in CLL and could be a potential target for antibody-based therapeutic interventions. Our study reaffirms the utility of post-alloHSCT antibody drug and target discovery. Cancer Immunol Res; 6(9); 1008–13. ©2018 AACR.
Comparison of 2 Perioperative Management Protocols and Their Influence on Postoperative Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Standard Parenteral Nutrition, Selective Bowel Decontamination and Suprapubic Catheters?
Authors: Elekonawo Fortuné M.K. , van der Meeren Manon M.D. , Simkens Geert A. , de Wilt Johannes H.W. , de Hingh Ignace H. , Bremers Andreas J.A. 
Published: July 2018

<b><i>Background:</i></b> Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is associated with considerable postoperative morbidity, including ileus and infectious complications. Perioperative care is believed to be an important factor for the development and treatment of postoperative morbidity. <b><i>Patients and Methods:</i></b> Data on case-matched patients from a retrospective database of 2 Dutch HIPEC centres was compared. Patient selection and procedures were identical in both hospitals although perioperative management items differ slightly. In centre B, immediate total parenteral nutrition (TPN), suprapubic urine bladder catheter placement (SPCs) and selective decontamination of the digestive-tract are standard care for CRS-HIPEC patients, while in centre A, they are not. <b><i>Results:</i></b> From a total of 223 patients, 68 consecutive patients from centre B were compared to 68 matched patients from centre A. TPN was administered to 54.4% of patients in centre A because of prolonged ileus, whereas it was standard of care in centre B. In all, 105 (77.2%) patients experienced postoperative complications including 17.6% who had a grades III–IV complication. The incidence of grade III-V complications was 18 (26.4%) in centre A and 8 (11.8%) in centre B (<i>p</i> = 0.03). Median hospital stay was 12 days (7–84) in A and 11(6–80) in centre B (<i>p</i> = 0.546). <b><i>Conclusions:</i></b> Gastrointestinal recovery after CRS-HIPEC seems to take longer as compared to other surgical procedures. Between the 2 centres, a significant difference in severe complications was found, while standard TPN, selective bowel decontamination and SPCs were the only identified differences in perioperative care.
Resumptive Pronouns Can Ameliorate Illicit Island Extractions
Authors: Ackerman Lauren , Frazier Michael , Yoshida Masaya 
Published: July 2018

Syntax literature reports that resumptive pronouns (RPs) ameliorate island violations, but much psycholinguistics literature has found RPs to be no more acceptable than straightforwardly island-violating gaps, even though island production tasks consistently elicit RPs. However, psycholinguistic studies have typically compared RP and illicit gap conditions indirectly. We posit that RP island amelioration in comprehension is undetectable when participants cannot compare alternative sentences, and thus that the apparent production/comprehension split arises from methodological differences between perception and production experiments. We present six experiments crossing three island types in two tasks (full-sentence forced choice and forced-choice fill-in-the-blank), manipulating gap location (island vs. nonisland). We find that RPs are preferred in islands and gaps in nonislands ( p = .0001). This suggests that RPs do ameliorate island violations and that the production/comprehension split is a methodological artifact.