bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of an Inpatient Social Needs Screening Program: Did Our Referral Resolve Your Need?
Authors: Lax Yonit , Pacheco Angelica , Yost Emma , Mathai Melvin , Silver Michael , Vasan Aditi , Coria Alexandra 
Published: November 2024

OBJECTIVE
To evaluate the effectiveness of social resource referrals after social needs screening among caregivers of pediatric inpatients by assessing (1) the rates of resource connection, (2) caregiver perception of resource helpfulness, (3) barriers to connection, and (4) resolution of needs.

METHODS
We conducted a cross-sectional survey of families discharged from our pediatric inpatient floor between October 2021 and June 2022 who had screened positive for unmet social needs and received a referral to at least 1 community resource during their hospitalization. We surveyed caregivers by telephone 1 month to 1 year post-intervention, inquiring about their perception of and experience with referrals. We compared responses across groups using χ2 tests. Multivariable logistic regression was used to predict the likelihood of resource connection based on race, ethnicity, language, and insurance type.

RESULTS
Of 361 families that screened positive for social needs and received a referral, 219 (61%) completed surveys. A total of 50.2% (110/219) of caregivers connected to at least 1 community resource, and 30.6% (67/219) connected to all referrals. Of 515 referrals, 315 (61.2%) did not result in resource connection. The most frequent barrier was families not recalling receiving the referral (44.8%, 141/315). Of 200 referrals that resulted in resource connection, 152 (76%) were helpful and 120 (60%) resolved the need. Non-Hispanic or Latino ethnicity predicted connection to resources.

CONCLUSIONS
Screening hospitalized children for social needs can result in meaningful resource connections. In our population, language, race, and insurance did not impact connection to resources. However, two-thirds of referrals did not result in resource connection.
2024 American Heart Association and American Academy of Pediatrics Focused Update on Special Circumstances: Resuscitation Following Drowning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Authors: McCallin Tracy E. , Dezfulian Cameron , Bierens Joost , Dunne Cody L. , Idris Ahamed H. , Kiragu Andrew , Mahgoub Melissa , Shenoi Rohit P. , Szpilman David , Terry Mark , Tijssen Janice A. , Tobin Joshua M. , Topjian Alexis A. 
Published: November 2024

Drowning is the third leading cause of death from unintentional injury worldwide, accounting for 7% of all injury-related deaths. In the United States, drowning is the leading cause of death in children 1 to 4 years of age and second leading cause of death due to unintentional injury in those aged 5 to 14 years. Drowning generally progresses from initial respiratory arrest due to submersion-related hypoxia to cardiac arrest; thus, it can be challenging to distinguish respiratory arrest from cardiac arrest because pulses are difficult to accurately palpate within the recommended 10-second window. Therefore, resuscitation from cardiac arrest due to this specific circumstance must focus on restoring breathing as much as it does circulation. Resuscitation from drowning may begin with in-water rescue breathing when safely provided by rescuers trained in the technique and should continue with chest compressions, in keeping with basic life support guidelines, once the drowned individual and the rescuer are in a safe environment (eg, dry land, boat).
This focused update incorporates systematic reviews from 2021 to 2023 performed by the International Liaison Committee on Resuscitation related to the resuscitation of drowning. These clinical guidelines are the product of a committee of experts representing the American Academy of Pediatrics and the American Heart Association. The writing group reviewed the recent International Liaison Committee on Resuscitation systematic reviews, including updated literature searches, prior guidelines related to resuscitation from cardiac arrest following drowning, and other drowning-related publications from the American Academy of Pediatrics and the American Heart Association. The writing group used these reviews to update its recommendations aimed at resuscitation from cardiac arrest following drowning in children.
АТОМНО-АБСОРБЦІЙНЕ ВИЗНАЧЕННЯ КОБАЛЬТУ В КУХОННІЙ СОЛІ ТА РОЗСОЛАХ
Authors: Юрченко Олег І. , Черножук Тетяна В. , Кравченко Олексій А. , Бакланов Олександр М. 
Published: November 2024

Досліджено екстракцію кобальту у вигляді діетилдитіокарбамату метилізобутилкетоном та хлороформом із розчинів кухонної солі. Встановлено, що заважаючий вплив хлориду натрію починається за використання метилізобутилкетону з 50 г/дм3, а за використання хлороформу – з 90 г/дм3. Показано, що фульвокислоти у концентрації понад 12.0 мг/дм3 занижують результати визначення кобальту, що робить кількісне визначення неможливим без руйнування розчинних органічних сполук. Запропоновано для руйнування розчинних органічних речовин кобальту використовувати дію ультразвуку частотою 18–44 кГц та інтенсивністю ≥ 5 Вт/см2 протягом не менше 60 с. Встановлено, що за використання екстракційної системи діетилдитіокарбамат натрію – метилізобутилкетон нижня межа визначення кобальту становить 0.90 мг/кг, що недостатньо для аналізу реальних об’єктів кухонної солі. Під час використання екстракційної системи діетилдитіокарбамат натрію – хлороформ нижня межа визначення кобальту дорівнює 0.04 мг/кг, що недостатньо для визначення кобальту в вакуум-випарній кухонній солі. Досліджено вплив концентрацій поверхнево-активних речовин на величину аналітичного сигналу в ході атомно-абсорбційного визначення кобальту. Показано, що максимальна чутливість визначення кобальту досягається за умови використання водних розчинів Тритон Х-100 (ω = 5 %). Водночас чутливість визначення кобальту підвищується у 1.53 рази. Розроблено методику визначення кобальту в кухонній солі та розсолах. Межа виявлення кобальту – 0.026 мг/кг.
Comparative analysis of diatom testing and histopathological examination in lungs: An experimental study in Wistar rats
Authors: Dervišević Emina , Čamdžić Nina , Mašić Ermin , Dervišević Amela , Bešić Aida , Ajanović Zurifa , Dervišević Muamer , Šuta Nedim , Kuskunović-Vlahovljak Suada 
Published: November 2024

AbstractMicroscopic signs indicative of drowning are not specific to drowning but also to any other form of suffocation where mechanical obstruction is involved. Our study aimed to evaluate both macroscopic and microscopic findings across different groups sharing a common mechanism of death but differing causes and to compare the diatom test with pathohistological examination.Twenty-nine adult Wistar rats, weighing within recommended ranges, were divided into four groups (L1–L4). The diatom test followed established guidelines for diatoms in water from the Bosna River. Microscopic examination revealed diatoms in the lungs of rats in L3 and L4 groups. Pathohistological findings showed varying degrees of changes including consolidation and inflammatory cell infiltration, dominated by lymphocytes and macrophages, with some samples also showing eosinophilic leukocytes.Significant differences were observed between animals whose cause of death was mechanical asphyxia (suffocatio) and those that were submersed for1 hour versus those that were submersed for 72 hours after death. Diatoms identified in group L4 samples 3, 4, and 5 included Navicula sp. (U3 and U6) and Ulnaria ulna (U4).Our findings suggest combining the diatom test with pathohistological analysis to support a drowning diagnosis. Further examination of other organs could enhance result reliability.
A Middle Palaeolithic workshop at Andornaktálya-Marinka site (Northeast Hungary)
Authors: Kerekes Dalma , Cserpák Ferenc , Mester Zsolt 
Published: November 2024

AbstractAlthough many Palaeolithic open-air sites are known on the foothills of the Bükk Mountains near Eger, Andornaktálya-Marinka was only discovered in 2014 thanks to new vine plantations on a hilltop. It was prospected regularly until 2019, and a test excavation was carried out in 2018. The archaeological material consists of a few undiagnostic prehistoric ceramic sherds and daub fragments, and 1706 stone artefacts. Except two fragments of polished axes, the lithic assemblage contains knapped stones. The paper presents the analysis of the lithic assemblage. This demonstrates the characteristics of an ‘older’ flake industry using almost exclusively local and regional raw materials, and those of a ‘younger’ blade industry working with long-distance ‘northern’ flints. The ‘older’ can be attributed to the Middle Palaeolithic Bábonyian, while the ‘younger’ should be related to Early Upper Palaeolithic Aurignacian or even to a Late Neolithic or Copper Age occupation.
Misprocessing of α-Galactosidase A, Endoplasmic Reticulum Stress, and the Unfolded Protein Response
Authors: Živná Martina , Dostálová Gabriela , Barešová Veronika , Mušálková Dita , Svojšová Klára , Meiseles Doria , Kinstlinger Sara , Kuchař Ladislav , Asfaw Befekadu , Poupětová Helena , Vlášková Hana , Kmochová Tereza , Vyleťal Petr , Hartmannová Hana , Hodaňová Kateřina , Stránecký Viktor , Steiner-Mrázová Lenka , Hnízda Aleš , Živný Jan , Radina Martin , Votruba Miroslav , Sovová Jana , Trešlová Helena , Stolnaja Larisa , Reková Petra , Roblová Lenka , Honsová Eva , Rychlík Ivan , Dvela-Levitt Moran , Bleyer Anthony J. , Linhart Aleš , Sikora Jakub , Kmoch Stanislav 
Published: November 2024

Key Points

The clinical significance of a number of missense variants of α-galactosidase A is often ambiguous.Defective proteostasis of some missense α-galactosidase A variants induced chronic endoplasmic reticulum stress and the unfolded protein response.Endoplasmic reticulum stress and the unfolded protein response may explain clinical manifestations of non-classic Fabry disease.

Background
Classic Fabry disease is caused by GLA mutations that result in loss of enzymatic activity of α-galactosidase A, lysosomal storage of globotriaosylceramide, and a resulting multisystemic disease. In non-classic Fabry disease, patients have some preserved α-galactosidase A activity and a milder disease course. Heterozygous female patients may also be affected. While Fabry disease pathogenesis has been mostly attributed to catalytic deficiency of mutated α-galactosidase A, lysosomal storage, and impairment of lysosomal functions, other pathogenic factors may contribute, especially in nonclassic Fabry disease.

Methods
We characterized the genetic, clinical, biochemical, molecular, cellular, and organ pathology correlates of the p.L394P α-galactosidase A variant that was identified initially in six individuals with kidney failure by the Czech national screening program for Fabry disease and by further screening in an additional 24 family members.

Results
Clinical findings in affected male patients revealed a milder clinical course, with approximately 15% residual α-galactosidase A activity with normal plasma lyso-globotriaosylceramide levels and abnormally low ratio of these values. None of the four available kidney biopsies showed lysosomal storage. Laboratory investigations documented intracellular retention of mutated α-galactosidase A with resulting endoplasmic reticulum stress and the unfolded protein response, which were alleviated with BRD4780, a small molecule clearing misfolded proteins from the early secretory compartment. We observed similar findings of endoplasmic reticulum stress and unfolded protein response in five kidney biopsies with several other classic and non-classic Fabry disease missense α-galactosidase A variants.

Conclusions
We identified defective proteostasis of mutated α-galactosidase A resulting in chronic endoplasmic reticulum stress and unfolded protein response of α-galactosidase A expressing cells as a contributor to Fabry disease pathogenesis.
South African occupational therapists' orthotic management of trigger finger and factors influencing their decision regarding splinting type
Authors: Mathenjwa Kuhlekonke V. , Mpanza December M , Chantal Christopher 
Published: November 2024

Background: Orthotic management of trigger finger refers to the use of splints to immobilise affected joints. The prevalence of trigger finger and the management and treatment practices utilised by occupational therapists for this affliction in South Africa, are not yet documented.
Aim: To explore occupational therapists' orthotic management for clients with trigger finger in KwaZulu-Natal, and the factors influencing the therapists' decisions when prescribing orthoses.
Methods: A quantitative cross-sectional study design was implemented with a sample size of 102 via a stratified random sampling approach. A survey questionnaire was administered. Data were coded using frequencies and then descriptively analysed using SPSS.
Results: Findings indicated that trigger finger is common in clinical settings and the majority (99%) of the occupational therapists use splints when managing trigger finger and as a first line of treatment (69.9%). The joint-blocking splint is preferred by 96.6% of the participants with the MCP joint-blocking splint being favoured by 55.0%. The most considered factors when deciding on the splint type are clinical presentation (99.1%) and the client's occupation (92.4%), and the most preferred measures of the effectiveness of treatment are pain (97.1%) and range of motion (97%).
Conclusion: The study has demonstrated that the inconsistencies noted in global research also apply in KwaZulu-Natal. Therefore, further investigation on the effectiveness of splinting and a guide on deciding on splint type as well as appropriate outcome measures, are necessary to ensure that cclients receive optimal care through evidence-informed practice.
Implications for Practice:

This study informs further understanding of the current assessment ptior to splinting and treatment practices that occupational therapist in the South African context provide for their clients with trigger-finger.
The study demonstrates that irrespective of the participant's level of experience and their clinical settings, the considerations when deciding on splint types remain the same.
The results are consistent with available literature, particularly with which splint type to use. However, the development for a guide regarding the orthotic management of trigger finger covering aspects like the splint regime and the recommendations of exercises is vital, as discrepancies emerged largely fro these areas. The type of exercises, stages at which they may be introduced, duration and requenccy should be considered for deeper engagement.
the development of this protocol will ensure consistency of treatment and evidence-informed practice.
Imaging the main molecular biological subtypes of breast cancer: comparison of mammographic data and histological findings
Authors: Khodorovich O. S. , Kanakhina L. B. , Sherstneva T. V. , Kalinina-Masri A. A. , Dibirova Sh. M. 
Published: November 2024

Background. Breast cancer (BC) stands as one of the most prevalent malignancies affecting women, posing a significant threat to health and life. Timely diagnosis and treatment of BC play a pivotal role in enhancing patient survival rates.Aim. To explore such a method of visualization of BC as mammography and the correlation of its results with the data of histological and immunohistochemical studies, and their significance in planning organ-conserving operations.Materials and methods. The study involved 217 patients diagnosed with nodular BC (T1-2N1M0). AH patients underwent digital mammography, histological examination of biopsy and surgical specimens, and immunohistochemical analysis of tumor tissue (determination of the expression of sex hormone receptors (estrogen and progesterone), HER2/neu status and the status of the Ki-67 marker, reflecting the proliferative activity of tumor cells).Results. Comparison of mammographic and histological/immunohistochemical findings revealed significant differences in tumor visualization among major molecular subtypes of BC. A statistically significant association (p <0.001) was established between carcinoma in situ and radiological features such as spiculated margins and calcifications on mammography.Conclusion. Mammography emerges as an objective and accessible visualization method for BC, enabling assessment of tumor size and peritumoral region. However, for planning breast-conserving surgery for luminal and HER2-positive BC subtypes, a multimodal diagnostic approach is recommended to assess tumor spread, incorporating ultrasound and contrast-enhanced magnetic resonance imaging.
Estimation of the girls cost vaccination against human papillomavirus in the Siberian Federal District
Authors: Ananina O. A. , Zhuykova L. D. , Kolomiets L. A. , Choinzonov E. L. , Kononova G. A. , Pikalova L. V. 
Published: November 2024

Background. The non-declining cervical cancer incidence in the Siberian Federal District 16.30/0000 (in Russia - 13.80 /0000) necessitate preventive vaccination against the human papillomavirus (HPV).Aim. To evaluate the cost-effectiveness of HPV vaccination in girls aged 9-14 years in the Siberian Federal District as a whole and in the context of subjects with a 60, 80, 90 percent target cohort.Materials and methods. We studied the size of the female population aged 9-14 years in the constituent entities of the Siberian Federal District for 2022, the average total cost of the vaccine, information on the gross regional product per capita, form C51 “Distribution of deaths by gender, age groups and causes of death” of Tomsk region, 2022. Age-standardized rate per 100,000 population of morbidity and detection (in percentages) of pre-invasive cervix cancer (carcinoma in situ) in the Siberian Federal District were calculated per 100 newly diagnosed malignant cervix neoplasms in 2022.Results. In the Irkutsk, Tomsk regions, Altai and Krasnoyarsk territories age-standardized rate (16.6; 17.8; 16.3; 18.90 /0000, respectively), the detection rate of pre-invasive cancer was 48.0-82.4 %, which indicates on the effectiveness of measures for early cervical cancer diagnosis. In the Republics of Tyva, Altai, Khakassia, age-standardized rate (26.4; 20.1; 19.30 /0000, respectively), cancer in situ was diagnosed in 8.2-23.6 % of cases, which indicates an insufficient level and defects in the organization preventive examinations in medical institutions. In the first year of vaccination against HPV with 60 % coverage of a girls cohort 9-14 years old (n = 404,943), 9.3 billion rubles will be required, with 80 % coverage (539,924 girls) - more than 12.4 billion rubles, with 90 % coverage (607,415 girls) - more than 13.9 billion rubles for primary vaccination against HPV. In subsequent years, more than 2.5-2.8 billion rubles will be required annually. Over 5 years, with 90 % coverage of the population, the financial costs of vaccination will be (817.8 million rubles), and the subsequent 4 annual investments (163.6 million rubles per year). The economic damage caused by mortality from cervical cancer in the Tomsk region over five years (2018-2022) amounted to 3,166.4 million rubles.Conclusion. Using the example of the Tomsk region, it was noted that when comparing financial resources, the costs of vaccinating girls against HPV are 2.2 times less than the economic damage from cervical cancer mortality. Regional budget funding for girls vaccination in administrative territories is relevant before its integration into the national calendar of preventive vaccinations.
Dynamics of cervical intraepithelial neoplasia according to cytological and morphological data on the example of women’s consultations in Yekaterinburg
Authors: Lapikova S. N. , Saydullaeva K. Kh. , Rosyuk E. A. 
Published: November 2024

Aim. To analyze the dynamics of cervical intraepithelial neoplasia according to cytology and morphology data on the example of women’s consultations in Yekaterinburg.Materials and methods. A descriptive epidemiological study was conducted. The authors analyzed data from reports on the work of the cervical pathology office on the basis of two women’s consultations in Yekaterinburg: the women’s consultation No. 1 of Central City Clinical Hospital No. 6 and the women’s consultation No. 2 of Central City Clinical Hospital No. 6 for the period from the 1st quarter of 2022 to the 2nd quarter of 2023.Results. The number of results on the absence of pathological changes in the cytological examination of the cervix (negative for intraepithelial lesion or malignancy, NILM) increased quarterly in both the city’s women’s consultations during the analyzed time period. Low-grade squamous intraepithelial lesion (LSIL) has the highest proportion in the structure of abnormal cytological results. The observation group in the women’s consultation No. 1 is almost 2 times larger than in the women’s consultation No. 2 (р = 0.0048). Statistically significant differences are observed only in the frequency of ASC-US (р = 0.049). The authors did not reveal statistically significant differences in the findings of histological studies of cervical tissue.Conclusion. After Order No. 521p entered into force in Yekaterinburg, a larger number of patients were covered by cytological screening. The number of normal results increased due to healthy women, but the frequency of abnormal cytology results remains at the same level. This may be due to increased accessibility and improved quality of medical care. In patients who have undergone cervical screening, secondary prevention of cervical cancer can be effectively carried out.
Three Gorges Seismological Network: Monitoring Seismicity at the Three Gorges Reservoir Forebay
Authors: Chen Fang , Wang Dun , Yao Dongdong , Liao Wulin , Na Heiya 
Published: November 2024

Abstract
In this study, we report on a nodal seismic deployment targeting the forebay area of the Three Gorges Reservoir. This deployment aimed to enhance the detection of microearthquakes and refine the imaging of subsurface geological structures. The network’s first phase of operation spanned from 2 September 2020 to 16 November 2020. It consisted of 78 short-period seismometers with an approximate interstation distance of 5 km. Using advanced deep-learning algorithms for phase detection and event location, we identified 1165 seismic events in this period, which exceeds the 623 events identified in the manual catalog using the same dataset. The catalog’s magnitude of completeness is ML ∼−0.3. The experiment from this deployment can offer guidelines for future microseismic monitoring networks, allowing for the strategic design of nodal seismometer spacing and other key parameters to meet specific observational requirements.