bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of long-term follow-up and methimazole therapy outcomes of pediatric Graves’ disease: a single-center experience
Authors: Bayramoğlu Elvan , Elmaogulları Selin , Sagsak Elif , Aycan Zehra 
Published: March 2019

Abstract

Background
The management options for Graves’ disease in children are limited and there is controversy regarding optimal treatment. Remission rate with anti-thyroid drug (ATD) treatment in children is said to be lower than in adults. Definitive treatments are effective, but they often result in permanent hypothyroidism. The objective of this study was to investigate the outcome of methimazole treatment, identify significant predictors of a remission and evaluate the adverse effects of methimazole in a pediatric population of GD patients.

Methods
Medical records of the patients who had been diagnosed with Graves’ disease were screened retrospectively. Diagnostic criteria included elevated free thyroxine (fT4) and total triiodothyronine (T3), suppressed thyroid-stimulating hormone (TSH) and either positive thyroid-stimulating immunoglobulin (TSI) or thyroid receptor antibodies (TRABs) or clinical signs suggestive of Graves’ disease, for example, exophthalmos. Remission was defined as maintenance of euthyroidism for more than 12 months after discontinuing methimazole treatment.

Results
Of the 48 patients, provisional remission was achieved in 21 patients. Of the 21 patients, 14 experienced a relapse (66.6%). Remission was achieved in seven (24.1%) of 29 patients who received methimazole treatment for more than 2 years. In patients who achieved long-term remission, the male sex ratio and fT4 levels at diagnosis were significantly lower than the relapsed and non-remission groups, whereas the free triiodothyronine (fT3)/fT4 ratio and duration of methimazole treatment were significantly higher than the relapse group.

Conclusions
Long-term methimazole treatment in pediatric Graves’ disease would be appropriate. High fT4 levels at the time of diagnosis and male sex were associated with a risk of relapse.
The crystal structure of 3-cyclohexyl-1,5-dioxaspiro[5.5]undecane-2,4-dione, C15H22O4
Authors: Wu-Lan Zeng , Wan Xin 
Published: March 2019

Abstract
C15H22O4, monoclinic, P21/c (no. 14), a = 12.7370(5) Å, b = 11.4565(7) Å, c = 10.0430(6) Å, β = 103.340(1)°, V = 1425.95(13) Å3, Z = 4, R
gt(F) = 0.0508, wR
ref(F
2) = 0.1406, T = 296(2) K.
Crystal structure of (2,4-dimethoxybenzyl)triphenylphosphonium trifluoroacetate — trifluoroacetic acid (1/1), C31H27F6O6P
Authors: Smit Jireh B.M. , Marais Charlene , Malan Frederick P. , Bezuidenhout Barend C.B. 
Published: March 2019

Abstract
C31H27F6O6P, triclinic, P1̄ (no. 2), a = 8.0017(2) Å, b = 11.1702(3) Å, c = 17.8353(4) Å, α = 104.9000(10)°, β = 96.5360(10)°, γ = 97.7380(10)°, V = 1508.05(7) Å3, Z = 2, R
gt(F) = 0.0354, wR
ref(F
2) = 0.0896, T = 150(2) K.
Crystal structure of 1,1′-methylenebis(4-tert-butylpyridinium) tetrachloridocobaltate(II) – dichloromethane (1:1), C20H30Cl6CoN2
Authors: Ayom Gwaza E. , Zamisa Sizwe J. , Van Zyl Werner E. 
Published: March 2019

Abstract
C20H30Cl6CoN2, orthorhombic, Pbca (no. 61), a = 20.756(1) Å, b = 9.3427(5) Å, c = 27.6827(12) Å, V = 5368.1(5) Å3, Z = 8, R
gt(F) = 0.0235, wR
ref(F
2) = 0.0593, T = 100(2) K.
Association of Functional Movement Screen and Y-Balance Test Scores With Injury in High School Athletes
Authors: Lisman Peter , Hildebrand Emily , Nadelen Mary , Leppert Kyle 
Published: March 2019

Abstract
Lisman, P, Hildebrand, E, Nadelen, M, and Leppert, K. Association of functional movement screen and Y-Balance Test scores with injury in high school athletes. J Strength Cond Res 35(7): 1930–1938, 2021—The purpose of this study was to determine the association between functional movement screen (FMS) and Y-Balance Test (YBT) performance and lower extremity injury in a sample of male high school athletes. A total of 124 high school football (n = 89), lacrosse (n = 25), and baseball (n = 10) players underwent FMS and YBT before the start of their competitive seasons. Time loss lower extremity injury incidence data were tracked by each team's certified athletic trainer and used for analysis. Receiver operating characteristic (ROC) curves were calculated to determine the optimal cutpoints for FMS composite score (CS) and YBT measures, including CS and reach distance asymmetry for anterior, posteromedial, and posterolateral directions, for predicting injury. No cutpoints on the ROC curves maximized sensitivity and specificity; therefore, FMS CS and YBT measures (CS and asymmetry) were analyzed as continuous variables. Logistic regression models adjusted for age and sport revealed no significant associations between FMS CS and lower extremity injury (odds ratio [OR] = 0.99; 95% confidence interval [CI] = 0.83–1.20). Similar findings were found for YBT asymmetry in all directions (ORs ranged from 0.98 to 1.08) and CS (OR = 0.99; 95% CI = 0.95–1.04). There were also no significant associations between the presence of asymmetry and low score (score of 1) on any individual FMS test and injury. Overall, FMS and YBT were not associated with increased risk of lower extremity injury in this sample of high school athletes. These findings do not support the use of FMS and YBT as stand-alone injury risk assessments in high school athletes.
Reactive Strength Index and Knee Extension Strength Characteristics Are Predictive of Single-Leg Hop Performance After Anterior Cruciate Ligament Reconstruction
Authors: Birchmeier Thomas , Lisee Caroline , Geers Brent , Kuenze Christopher 
Published: March 2019

Abstract
Birchmeier, T, Lisee, C, Geers, B, and Kuenze, C. Reactive strength index and knee extension strength characteristics are predictive of single-leg hop performance after anterior cruciate ligament reconstruction. J Strength Cond Res 33(5): 1201–1207, 2019—Single-leg hop distance is incorporated into return to sport criteria after anterior cruciate ligament reconstruction (ACLR) because of its relationship with knee extension strength; however, it may be related to other strength and plyometric characteristics. The purpose of this study was to assess the association between isometric knee extension strength and plyometric characteristics, including amortization and reactive strength index (RSI), measured during a single-leg drop vertical jump and single-leg hop performance in individuals with unilateral ACLR. Participants attended 2 testing sessions. During the first session, a biomechanical analysis using a 3D motion capture system was performed to measure RSI and amortization during a single-leg drop vertical jump for maximal height. Participants completed a single hop and a triple hop for maximal distance. During the second session, isometric knee extension strength was measured during a maximal voluntary isometric contraction. Strength characteristics included peak torque, rate of torque development (RTD), RTD 0–100 ms (RTD 100), and RTD 100–200 ms (RTD 200). Fifty-two individuals (17 men/35 women) participated. Multivariable regression models revealed jump height, peak torque, and RTD 200 explained 60.9% of the variance in normalized single-leg hop distance (p < 0.001). Reactive strength index, peak torque, RTD 200, and RTD 100 significantly explained 61.8% of the variance in normalized triple hop distance (p < 0.001). Single hop distance may indicate improved knee extension strength, whereas triple hop distance may indicate improvement in reactive strength. Training to improve RSI may improve triple hop performance and clinical outcomes in this population.
Exercise Response to Real Combat in Elite Taekwondo Athletes Before and After Competition Rule Changes
Authors: Janowski Michał , Zieliński Jacek , Kusy Krzysztof 
Published: March 2019

Abstract
Janowski, M, Zieliński, J, and Kusy, K. Exercise response to real combat in elite taekwondo athletes before and after competition rule changes. J Strength Cond Res 35(8): 2222–2229, 2021—We hypothesize that recent (2017) changes in competition rules significantly affected kinematic (mechanical activity) and physiological (cardiopulmonary indices and lactate concentration) profile of the taekwondo combat, which is currently becoming more demanding in terms of exercise intensity and fatigue. Twenty two male and female elite taekwondo athletes were followed up for over 2 years. In total, 258 real tournament combats were included in the analysis (133 in old rules and 125 in new rules). Kinematic and physiological characteristics were recorded using a biomonitor (BioHarness 3; Zephyr Technologies) worn by athletes during tournaments. Blood samples were drawn after each combat for lactate concentration. Our research showed that recent amendments of competition rules were linked to a noticeable shift toward higher kinematic output and, consequently, increased physiological response. Significant increments in kinematic variables (3–8%), heart rate (HR) (1.5–1.8%), energy expenditure (EE) (3–5%), overall physiological load (2–4%), and lactate concentration (∼15% immediately after exercise and ∼25% in recovery) suggest that new rules are more demanding, although the statistical effect size is only small or moderate. In conclusion, after competition rule changes, there has been a shift in taekwondo combat profile toward greater body movement dynamics, higher intensity, and greater postexercise fatigue. The values of key indices of exercise response (mechanical activity, HR, EE, and lactate concentration) during tournaments are near or exceeding the maximum attained during progressive exercise until exhaustion. Therefore, more focus is needed on taekwondo-specific high-intensity training and postcombat recovery to adapt athletes to increased competition requirements.
A disease-specific Quality of Life questionnaire for primary aldosteronism
Authors: Velema Marieke Stientje , de Nooijer Aline , Hermus Ad R M M , Timmers Henri J L M , Lenders Jacques W M , Husson Olga , Deinum Jaap 
Published: March 2019

Objective
To develop a primary aldosteronism (PA) disease-specific Health-Related Quality of Life (HRQoL) questionnaire.

Methods
We included newly diagnosed patients with PA (n = 26), and patients with PA after adrenalectomy (n = 25) or treated with mineralocorticoid receptor antagonists (n = 25). According to the guidelines for developing HRQoL questionnaires from the European Organization for Research and Treatment of Cancer (EORTC): Phase I: systematic literature review followed by focus group meetings with patients (n = 13) resulting in a list of 94 HRQoL issues. Relevance of issues was rated by 18 other patients and by health care professionals (n = 15), resulting in 30 remaining issues. Phase II: selected issues were converted into questions. Phase III: the provisional questionnaire was pre-tested by a third group of patients (n = 45) who also completed the EORTC core Quality of Life questionnaire (QLQ-C30). Psychometric testing resulted in a final selection of questions with their scale structure.

Results
After the collection and selection of HRQoL issues a provisional questionnaire consisting of 30 items was formed. Of these items, 26 could be assigned to one of the four scales ‘physical and mental fatigue’, ‘anxiety and stress’, ‘fluid balance’ and ‘other complaints’ cumulatively accounting for 68% of variation in all items. All scales had good reliability and validity. There was a significant correlation of all four scales with the QLQ-C30 in most cases.

Conclusions
We developed the first PA-specific HRQoL questionnaire (PA-QoL) using standard, methodologically proven guidelines. After completion of the final validation (phase IV, international field testing), the questionnaire can be implemented into clinical practice.
Use of F2 Bulks in Training Sets for Genomic Prediction of Combining Ability and Hybrid Performance
Authors: Technow Frank 
Published: March 2019

AbstractDeveloping training sets for genomic prediction in hybrid crops requires producing hybrid seed for a large number of entries. In autogamous crop species (e.g., wheat, rice, rapeseed, cotton) this requires elaborate hybridization systems to prevent self-pollination and presents a significant impediment to the implementation of hybrid breeding in general and genomic selection in particular. An alternative to F1 hybrids are bulks of F2 seed from selfed F1 plants (F1:2). Seed production for F1:2 bulks requires no hybridization system because the number of F1 plants needed for producing enough F1:2 seed for multi-environment testing can be generated by hand-pollination. This study evaluated the suitability of F1:2 bulks for use in training sets for genomic prediction of F1 level general combining ability and hybrid performance, under different degrees of divergence between heterotic groups and modes of gene action, using quantitative genetic theory and simulation of a genomic prediction experiment. The simulation, backed by theory, showed that F1:2 training sets are expected to have a lower prediction accuracy relative to F1 training sets, particularly when heterotic groups have strongly diverged. The accuracy penalty, however, was only modest and mostly because of a lower heritability, rather than because of a difference in F1 and F1:2 genetic values. It is concluded that resorting to F1:2 bulks is, in theory at least, a promising approach to remove the significant complication of a hybridization system from the breeding process.
Фінансові ризики в електронних закупівлях, як елементу цифрової економіки
Authors: Дерменжі Діна Федорівна 
Published: March 2019

Споживання харчових продуктів є незмінною частиною нашого життя. На сьогоднішній день забезпечення харчуванням у навчальних закладах, в установах охорони здоров'я та взагалі в багатьох державних установах відбувається за допомогою електронних закупівель. Відповідно до Закону України «Про державні закупівлі», закупівля це - придбання замовником товарів, робіт і послуг в порядку, встановленому цим Законом [1]. Це є обов'язковим для всіх розпорядників бюджетних коштів і відображається на платформі Prozorro. Така спрямованість економіки є нічим іншим, як прикладом цифрової економіки. Цифрову економіку також іноді називають інтернет-економікою, новою економікою, або веб-економікою. [2] Під цифровий економікою найчастіше розуміють виробництво, продажу та поставки продуктів через комп'ютерні мережі, як і в нашому випадку. Мета «Prozorro» - максимальна прозорість процесу державних закупівель та простота доступу. Основним питанням, яке виникає за участю підприємства в таких закупівлях, це ризики. Вони є на будь-якому етапі діяльності, і можуть виникати незалежно від його дій. З огляду на досить недавнє виникнення такої електронної системи, проблема оцінки таких ризиків є досить важливою і вимагає вивчення. В системі публічних закупівель суб'єкт підприємницької діяльності виступає в ролі учасника, і саме цей статус і є причиною виникнення ризиків. Говорячи про цю систему, можна сказати, що тут в більшості випадків виникають саме фінансові ризики, в частині можливості втрати частину свого капіталу, а також неотримання бажаного доходу, або в недостатньому обсязі.Під втратою частини капіталу розуміється втрата коштів, сплачених за участь у тендерній процедурі. Незалежно від результатів процедури закупівлі вони не повертаються суб'єкту підприємницької діяльності. Під ризиком неотримання бажаного доходу розуміється такий випадок, коли незалежно від об'єктивних чи суб'єктивних причин учасник програє тендер і не отримує додаткового стабільного доходу. І останній випадок, коли підприємство отримує дохід менше бажаного. Це відбувається в результаті скорочення обсягів фінансування і зменшення обсягів закупівлі. Державні закупівлі одночасно є гарантом отримання стабільного доходу, але в той же час можуть стати і причиною його зменшення.
Urinary Soluble CD163 in Active Renal Vasculitis
Authors: O’Reilly Vincent P. , Wong Limy , Kennedy Claire , Elliot Louise A. , O’Meachair Shane , Coughlan Alice Marie , O’Brien Eoin C. , Ryan Michelle M. , Sandoval Diego , Connolly Emma , Dekkema Gerjan J. , Lau Jiaying , Abdulahad Wayel H. , Sanders Jan-Stephan F. , Heeringa Peter , Buckley Colm , O’Brien Cathal , Finn Stephen , Cohen Clemens D. , Lindemeyer Maja T. , Hickey Fionnuala B. , O’Hara Paul V. , Feighery Conleth , Moran Sarah M. , Mellotte George , Clarkson Michael R. , Dorman Anthony J. , Murray Patrick T. , Little Mark A. 
Published: March 2019

A specific biomarker that can separate active renal vasculitis from other causes of renal dysfunction is lacking, with a kidney biopsy often being required. Soluble CD163 (sCD163), shed by monocytes and macrophages, has been reported as a potential biomarker in diseases associated with excessive macrophage activation. Thus, we hypothesized that urinary sCD163 shed by crescent macrophages correlates with active glomerular inflammation. We detected sCD163 in rat urine early in the disease course of experimental vasculitis. Moreover, microdissected glomeruli from patients with small vessel vasculitis (SVV) had markedly higher levels of CD163 mRNA than did those from patients with lupus nephritis, diabetic nephropathy, or nephrotic syndrome. Both glomeruli and interstitium of patients with SVV strongly expressed CD163 protein. In 479 individuals, including patients with SVV, disease controls, and healthy controls, serum levels of sCD163 did not differ between the groups. However, in an inception cohort, including 177 patients with SVV, patients with active renal vasculitis had markedly higher urinary sCD163 levels than did patients in remission, disease controls, or healthy controls. Analyses in both internal and external validation cohorts confirmed these results. Setting a derived optimum cutoff for urinary sCD163 of 0.3 ng/mmol creatinine for detection of active renal vasculitis resulted in a sensitivity of 83%, specificity of 96%, and a positive likelihood ratio of 20.8. These data indicate that urinary sCD163 level associates very tightly with active renal vasculitis, and assessing this level may be a noninvasive method for diagnosing renal flare in the setting of a known diagnosis of SVV.
Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia
Authors: Zhang Jie , Wei Jin , Jiang Shan , Xu Lan , Wang Lei , Cheng Feng , Buggs Jacentha , Koepsell Hermann , Vallon Volker , Liu Ruisheng 
Published: March 2019

Significance Statement
Although glomerular hyperfiltration is common in early diabetes and considered a risk factor for later diabetic nephropathy, the mechanisms underlying glomerular hyperfiltration have not been fully clarified. The authors identified a novel mechanism of acute hyperglycemia–induced hyperfiltration in which increases in luminal glucose at the macula densa upregulate the expression and activity of neuronal nitric oxide synthase 1 (NOS1) via sodium-glucose cotransporter 1 (SGLT1); this blunts the tubuloglomerular feedback (TGF) response and promotes glomerular hyperfiltration. This novel SGLT1-NOS1-TGF pathway mediates the glomerular hyperfiltration observed in response to acute hyperglycemia. These findings establish a critical role of macula densa NOS1 and SGLT1 as key determinants of, and potential therapeutic targets for, acute hyperglycemia–associated glomerular hyperfiltration, and possibly for diabetes as well.

Background
Glomerular hyperfiltration is common in early diabetes and is considered a risk factor for later diabetic nephropathy. We propose that sodium-glucose cotransporter 1 (SGLT1) senses increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric oxide synthase 1 (NOS1)–dependent nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) response, thereby promoting the rise in GFR.

Methods
We used microperfusion, micropuncture, and renal clearance of FITC–inulin to examine the effects of tubular glucose on NO generation at the macula densa, TGF, and GFR in wild-type and macula densa–specific NOS1 knockout mice.

Results
Acute intravenous injection of glucose induced hyperglycemia and glucosuria with increased GFR in mice. We found that tubular glucose blunts the TGF response in vivo and in vitro and stimulates NO generation at the macula densa. We also showed that SGLT1 is expressed at the macula densa; in the presence of tubular glucose, SGLT1 inhibits TGF and NO generation, but this action is blocked when the SGLT1 inhibitor KGA-2727 is present. In addition, we demonstrated that glucose increases NOS1 expression and NOS1 phosphorylation at Ser1417 in mouse renal cortex and cultured human kidney tissue. In macula densa–specific NOS1 knockout mice, glucose had no effect on NO generation, TGF, and GFR.

Conclusions
We identified a novel mechanism of acute hyperglycemia–induced hyperfiltration wherein increases in luminal glucose at the macula densa upregulate the expression and activity of NOS1 via SGLT1, blunting the TGF response and promoting glomerular hyperfiltration.
20. YY. SONRASI SANAT PRATİĞİ İÇERİSİNDE SANATÇI DEFTERİNDEN SANATÇI KİTABINA BAKIŞ
Authors: OKTAY Güneş 
Published: March 2019

Sanatın gelişim süreciyle benzer eğilimler gösteren sanatçı
defteri, sergilenen bir nesneye dönüşmesiyle araçken amaç konumuna gelir.
Karalamalar, notlar ve taslaklardan oluşan sanatçı defterinin sergilenmesi onu
sanat eseri durumuna getirirken; sanat nesnesi olarak kabul edilen sanatçı
kitabı üretimiyle benzer eğilimler göstermeye başlar.

Sanatçı
kitabı üretiminin aslında yeni olması onun tam bir tanımını yapmayı zorlaştırsa
da, süreç içerisinde form ve içerik
olarak yenilik ve alternatif arayışların birer nesnesi haline gelmesi, onun ne
olduğuna dair belli ipuçları verir. Kitabın formuna odaklanılarak onun bozulup
yeniden kurgulandığı örnekler olduğu gibi, kitap zaman içerisinde sanatçıya
özgürlük alanı yaratan ve alternatif sergileme yöntemi sunan bir araç da olmaya
başlar. Sanatçı kitabının kendisi
doğrudan bir proje ya da sergileme alanı olabilirken, bir mekanda sergilenen
işler arasında da yer alabilir. Günümüzde endüstriyel üretime yönelik
alternatif yaklaşımların birer ürünü olarak da kendisine yer edinen sanatçı
kitabı, genel olarak var olanı sorgulayan bir tavır içerisindedir.

Sanatçı
defterinin sergilenerek sanatsal üretimin bir parçası haline gelmesi ile
sanatçı kitabına ait üretim ve yöntem pratiklerinin araştırıldığı bu çalışmada,
sanatçı defteri ile sanatçı kitabı arasındaki benzerlik ve farklılıklar üzerine
sorgulamalar yapılmış, yurt içi ve yurt dışındaki örneklerinde günümüz sanat
anlayışı içerisindeki konumu incelenmiştir.