bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA HCG11 modulates glioma progression through cooperating with miR‐496/CPEB3 axis
Authors: Chen Yangzong , Bao Chunchun , Zhang Xiuxing , Lin Xinshi , Huang Hongou , Wang Zhiqiang 
Published: July 2019

AbstractObjectivesIt has been widely reported that long non‐coding RNAs (lncRNAs) can participate in multiple biological processes of human cancers. lncRNA HLA complex group 11 (HCG11) has been reported in human cancers as a tumour suppressor. This study focused on investigating the function and mechanism of HCG11 in glioma.Materials and methodsBased on The Cancer Genome Atlas (TCGA) data set and qRT‐PCR analysis, the expression pattern of HCG11 was identified in glioma samples. The mechanism associated with HCG11 downregulation was determined by mechanism experiments. Gain‐of‐function assays were conducted for the identification of HCG11 function in glioma progression. Mechanism investigation based on the luciferase reporter assay, RIP assay and pull‐down assay was used to explore the downstream molecular mechanism of HCG11. The role of molecular pathway in the progression of glioma was analysed in accordance with the rescue assays.ResultsHCG11 was expressed at low level in glioma samples compared with normal samples. FOXP1 could bind with HCG11 and transcriptionally inactivated HCG11. Overexpression of HCG11 efficiently suppressed cell proliferation, induced cell cycle arrest and promoted cell apoptosis. HCG11 was predominantly enriched in the cytoplasm of glioma cells and acted as a competing endogenous RNAs (ceRNAs) by sponging micro‐496 to upregulate cytoplasmic polyadenylation element binding protein 3 (CPEB3). CEPB3 and miR‐496 involved in HCG11‐mediated glioma progression.ConclusionsHCG11 inhibited glioma progression by regulating miR‐496/CPEB3 axis.
Plasma cytokine profile on admission related to aetiology in community‐acquired pneumonia
Authors: Burgmeijer Eduard H. , Duijkers Ruud , Lutter René , Bonten Marc J. M. , Schweitzer Valentijn A. , Boersma Wim G. 
Published: July 2019

AbstractBackgroundPotentially unnecessary antibiotic use for community‐acquired pneumonia (CAP) contributes to selection of antibiotic‐resistant pathogens. Cytokine expression at the time that treatment is started may assist in identifying patients not requiring antibiotics. We determined plasma cytokine patterns in patients retrospectively categorized as strict viral, pneumococcal or combined viral‐bacterial CAP.ObjectiveTo investigate whether cytokine‐based prediction models can be used to differentiate strict viral CAP from other aetiologies at admission.MethodsFrom 344 hospitalized CAP patients, 104 patients were categorized as viral CAP (n = 17), pneumococcal CAP (n = 48) and combined bacterial‐viral CAP (n = 39). IL‐6, IL‐10, IL‐27, IFN‐γ and C‐reactive protein (CRP) were determined on admission in plasma. Prediction of strict viral aetiology was explored with two multivariate regression models and ROC curves.ResultsViral pneumonia was predicted by logistic regression using multiple cytokine levels (IL‐6, IL‐27 and CRP) with an AUC of 0.911 (95% CI: 0.852‐0.971, P < .001). For the same patients the AUC of CRP was 0.813 (95% CI: 0.728‐0.898, P < .001).ConclusionsThis study demonstrated differences in cytokine expression in selected CAP patients between viral and bacterial aetiology. Prospective validation studies are warranted.
Post‐transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group
Authors: O'Neill James Paul , Sexton Donal J. , O'Leary Eamonn , O'Kelly Patrick , Murray Susan , Deady Sandra , Daly Fergus , Williams Yvonne , Dean Ben , Fitzgerald Conall , Murad Aizuri , Mansoor Nazish , O'Neill Jim O. , Egan Jim , Houlihan Diarmaid D. , McCormick P. Aiden , Morris Patrick G. , Ni Raghallaigh Siona , Little Dilly , Moloney Fergal J. , Conlon Peter J. 
Published: July 2019

AbstractObjectiveSolid organ transplant recipients are at increased risk of cancer compared to the general population. To date, this risk in Ireland has not been investigated. We conducted a national registry study of cancer incidence following solid organ transplantation.MethodsNational centers for solid organ transplantation supplied their respective registry databases to cross‐reference with episodes of malignancy from the National Cancer Registry Ireland (NCRI) between 1994 and 2014. Standardized incidence of cancer post‐transplant was compared to the general population by means of standardized incidence ratios (SIRs), and between solid organ transplant types by incidence rate ratios.ResultsA total of 3346 solid organ transplant recipients were included in this study. Kidney transplant recipients constituted the majority of participants (71.2%), followed by liver (16.8%), heart (6.4%), and lung (5.6%) transplants. The most common cancers within the composite of all transplant recipients included the following (SIR [95% CI]): squamous and basal cell carcinoma (20.05 [17.97, 22.31] and 7.16 [6.43, 7.96], respectively), non‐Hodgkin lymphoma (6.23 [4.26, 8.59]), and renal cell carcinoma (3.36 [1.96, 5.38]).ConclusionsThis study reports the incidence of cancer following solid organ transplantation in Ireland. These results have significant national policy implications for surveillance, and early diagnosis in this patient group.
Infants attribute false beliefs to a toy crane
Authors: Burnside Kimberly , Severdija Vivianne , Poulin‐Dubois Diane 
Published: July 2019

AbstractThe mentalistic view of early theory of mind posits that infants possess a robust and sophisticated understanding of false belief that is masked by the demands of traditional explicit tasks. Much of the evidence supporting this mentalistic view comes from infants’ looking time at events that violate their expectations about the beliefs of a human agent. We conducted a replication of the violation‐of‐expectation procedure, except that the human agent was replaced by an inanimate agent. Infants watched a toy crane repeatedly move toward a box containing an object. In the absence of the crane, the object changed location. When the crane returned, 16‐month‐old infants looked longer when it turned toward the object's new location, consistent with the attribution of a false belief to the crane. These results suggest that infants spontaneously attribute false beliefs to inanimate agents. A video abstract of this article can be viewed at https://youtu.be/qqEPPhd9FDo
Early risk and protective factors and young adult outcomes in a longitudinal sample of young people with a history of psychotic‐like experiences
Authors: Coughlan Helen , Healy Colm , Ní Sheaghdha Áine , Murray Gareth , Humphries Niamh , Clarke Mary , Cannon Mary 
Published: July 2019

AbstractAimPsychotic‐like experiences (PEs) have been associated with childhood adversity and psychopathology. However, few studies have examined the dynamic interplay between risk and protective factors and later life outcomes in people with PEs. This study aimed to explore and compare patterns of early adverse and protective experiences and young adult outcomes in a sample of young people with a history of PEs.MethodLongitudinal qualitative data spanning nine years were collected from a general population sample of seventeen young adults who had reported PEs in early adolescence. A qualitative comparative case study design was used to explore patterns of early life experiences and young adult outcomes.ResultsFour archetypal profiles of early life experiences and later outcomes were identified. Qualitative differences between types of early adverse experiences and the quality of attachment relationships were dominant discriminating factors between low‐risk and at‐risk archetypes for poor young adult outcomes. Experiences of multiple adversities, which included childhood trauma and occurred in the absence of secure attachment relationships was associated with the poorest young adult outcomes. The presence of secure attachment relationships was protective, even among individuals who had experienced adversity.ConclusionsNot all young people who report PEs have high levels of adversity. Those who experience multiple early adversities, childhood trauma and insecure attachment relationships are at highest risk for reoccurring PEs and poor young adult outcomes. Developing trusted attachment relationships and engaging in corrective experiences may be protective and could promote positive outcomes in youth with PEs.
Treatments for chronic pruritus outside of the box
Authors: Metz Martin 
Published: July 2019

AbstractPatients with chronic pruritus are in desperate need of novel treatment options, as current therapeutic possibilities are often not effective, have a poor level of evidence and are mostly off‐label. In recent years, much effort has been put into the identification of potential targets for the treatment of chronic pruritus. More importantly, a number of promising new drugs that are aimed at treating pruritus in different conditions are currently in advanced stages of clinical trials. Here, current pharmacological developments leading to potential new drugs for the treatment of chronic pruritus within various conditions are summarized. Hopefully, these new approaches will result in effective and safe therapies for our patients with chronic pruritus associated with dermatological or non‐dermatological diseases in the near future.
Added value? Denaturalizing the “good” of urban greening
Authors: Angelo Hillary 
Published: July 2019

AbstractIn recent years, “urban greening” has become a new keyword in urban policy and practice, used to describe a proliferation of urban quality of life and environmental sustainability initiatives including street trees, public parks, greenways, farmers' markets, green roofs, and LEED certification in design. The emerging critical literature on urban greening has highlighted important ways green's social and economic added value affects the political economy of contemporary greening and produces inequalities in access to real or perceived environmental goods. However, such research has only infrequently asked why and under what conditions naturalized understandings of green as “good” make it possible for such initiatives to add value in the first place. As a result, it offers only partial explanations of why green has the effects it has—for instance, increasing property values—and only very rarely questions the fundamental “good” of nature itself. I argue that integrating insights on green's naturalized social and economic value from a growing body of social‐theoretical work across geography and the social sciences can complement political economic explanations for greening and provide new vantage points for critique.
Reforming post‐Communist bureaucracies: The effect of transitional justice
Authors: Kostadinova Tatiana , Neshkova Milena I. 
Published: July 2019

AbstractObservers of post‐Communist politics recognize that civil service reform, an important part of the institutional transformation in Eastern Europe, was initiated at a very uneven pace. Hungary and Poland adopted changes quickly after the fall of Communism, while Romania and Slovakia waited longer. How can one explain the timing of civil service reform after 1989? Previous research blames a number of factors but inconsistencies between predictions and actual outcomes warrant a more thorough investigation. What has been overlooked, we argue, are the policies of transitional justice that altered the costs and benefits for elites to keep the institutional status quo. The empirical analysis reveals that when in place, lustration by vetting of public officials reduced the likelihood of passing a civil service reform act. This effect is conditioned by the legislative strength of ex‐Communist parties, as demonstrated by results from logistic regression tests on data from 11 countries.
Relationship of Migraine and Tension‐Type Headache With Hypothyroidism: A Literature Review
Authors: Spanou Ioanna , Bougea Anastasia , Liakakis George , Rizonaki Konstantina , Anagnostou Evangelos , Duntas Leonidas , Kararizou Evangelia 
Published: July 2019

BackgroundMigraine, tension‐type headache, and hypothyroidism constitute very common medical conditions. Headache is one of the most common symptoms of hypothyroidism, occurring in approximately one‐third of the patients. To date, data about the relationship between migraine and tension‐type headache and thyroid dysfunction, and in particular hypothyroidism have been contradictory, while the underlying pathophysiological basis explaining this association is still unclear.ObjectiveIn this review, we investigated the association between primary headaches and hypothyroidism, with the aim of shedding light on its pathophysiological basis.MethodsWe conducted a systematic search in the MEDLINE database using both subject headings and keywords for headache, migraine, tension‐type headache, thyroid hormones, and hypothyroidism, and we also examined manually the reference lists of all articles that met the inclusion criteria. Included studies were related to headache and thyroid disease comorbidity, with emphasis on hypothyroidism (ideally demonstrated by hormonal measurements), and with the term headache including migraine, tension‐type headache, and headache attributed to hypothyroidism (HAH) based on the International Classification of Headache Disorders IIIb. Quality of studies was assessed by the Newcastle‐Ottawa scale.ResultsOf a total of 640 identified articles, 9 studies were included. Overall, there was vast heterogeneity across the included studies concerning population, study design and outcomes. Two studies investigated the HAH, with emphasis on the clinical characteristics of headache (time of onset, localization, quality, intensity, and response to hormonal replacement treatment). Five studies investigated comorbidity between migraine and thyroid disorders, especially hypothyroidism, and in the majority of them a positive association was demonstrated. One study found that headache, and particularly migraine, may increase the risk of developing hypothyroidism. Finally, only 1 study on chronic tension‐type headache found coexistence of migraine and hypoactivity of the hypothalamus‐pituitary‐thyroid axis. The strengths and limitations of these studies are analyzed and possible pathophysiological mechanisms are suggested.ConclusionsThe existing data are considered inadequate to answer with certainty the relationship between headaches and thyroid disorders. According to our analysis, it seems that suggestions for a possible bidirectional association between headaches and especially migraine and hypothyroidism could exist. It hence lays the foundation for further research into the aforementioned association and its pathogenesis via large prospective multicenter studies.
Parent escalation of care for the deteriorating child in hospital: A health‐care improvement study
Authors: Gill Fenella J. , Leslie Gavin D. , Marshall Andrea P. 
Published: July 2019

AbstractObjectiveTo evaluate the implementation of an intervention for parents to escalate care if concerned about their child's clinical condition.DesignMixed‐methods health‐care improvement approach guided by the Theoretical Domains Framework.MethodsImplementation of the ‘Calling for Help’ (C4H) intervention was informed by previously identified barriers and facilitators. Evaluation involved audit, review of clinical deterioration incidents, interviews and focus groups.SettingAustralian specialist paediatric hospital.ParticipantsConvenience sample of 75 parents from inpatient areas during the audit, interviews with ten parents who had expressed concern about their child's clinical condition; five focus groups with 35 ward nurses.Main outcome measuresParent awareness and utilization of C4H, parent and nurse views of factors influencing implementation.ResultsParent awareness of C4H improved to 35% (25/75). Parent concern was documented prior to 21/174 (12%) clinical deterioration events. All interviewed parents and nurses who participated in focus groups were positive about C4H. Parents preferred to be informed about C4H by nurses, but nurses described this as time‐consuming and selectively chose parents who they believed would benefit most. Parents and nurses described frustrations with and trepidation in escalating care. Nurses had used C4H to expedite urgent medical review.ConclusionsThere was an improvement in the level of parent awareness of C4H, which was viewed positively by parents and nurses alike. To achieve a high level of parent awareness in a sustainable way, a multifaceted approach is required. Further strategies will be required for parents to feel confident enough to use C4H and to address interprofessional communication barriers.
Lynch syndrome screening in gynaecological cancers: results of an international survey with recommendations for uniform reporting terminology for mismatch repair immunohistochemistry results
Authors: Ryan Neil , Wall Johanna , Crosbie Emma J , Arends Mark , Bosse Tjalling , Arif Saimah , Faruqi Asma , Frayling Ian , Ganesan Raji , Hock Ye L , McMahon Raymond , Manchanda Ranjit , McCluggage W Glenn , Mukonoweshuro Pinias , van Schalkwyk Gerhard , Side Lucy , Smith John H , Tanchel Bruce , Evans D Gareth , Gilks C Blake , Singh Naveena 
Published: July 2019

AimsLynch syndrome (LS) is associated with an increased risk of developing endometrial carcinoma (EC) and ovarian carcinoma (OC). There is considerable variability in current practices and opinions related to screening of newly diagnosed patients with EC/OC for LS. An online survey was undertaken to explore the extent of these differences.Methods and resultsAn online questionnaire was developed by a panel of experts and sent to all members of the British Association of Gynaecological Pathologists (BAGP) and the International Society of Gynecological Pathologists (ISGyP). Anonymised results were received and analysed. Thirty‐six BAGP and 44 ISGyP members completed the survey. More than 90% of respondents were aware of the association of LS with both EC and OC, but 34% were not aware of specific guidelines for LS screening. Seventy‐one per cent of respondents agreed that universal screening for LS should be carried out in all newly diagnosed EC cases, with immunohistochemistry (IHC) alone as the preferred approach. Only 36% of respondents currently performed IHC or microsatellite instability testing on all newly diagnosed EC cases, with most of the remaining respondents practising selective screening, based on clinical or pathological features or both. A significant minority of respondents (35%) believed that patient consent was required before performance of mismatch repair (MMR) protein IHC. Almost all respondents favoured the use of standardised terminology for reporting MMR protein staining results, and this is proposed herein.ConclusionThere is wide support for universal LS screening in patients with EC, but this survey highlights areas of considerable variation in practice.
Morphometric characteristics of feminine eyebrows: variations with ethnicities and age
Authors: Flament F. , Seyrek I. , Francois G. , Zhu T. , Ye C. , Saint‐Leger D. 
Published: July 2019

AbstractObjectiveTo explore some morphological features of the eyebrows of women of different ethnicities and ages.Materials and MethodsStandard digital photographs of 3600 women of six ethnicities, aged 18–84 years, previously used to describe the morphology of the human eyes, allowed us to focus on their eyebrows, as supplementary and opportunistic study. Photographs of both eyebrows were analysed partly by manual markings and automatically by dedicated algorithms. Six parameters of the eyebrows were recorded: length, waviness/curvature, oblique aspect, size (vertical height), total surface and hair coverage (density).ResultsMost criteria present ethnic specificities. These are: length (longer eyebrows of Indian, shorter among African women); waviness where the straighter eyebrows were found among Chinese and Japanese women. In general, the longer the eyebrows, the higher their waviness and vice versa. Thickness (or height) of the eyebrows presents a wide ethnic variability as well as hair coverage, where African women present the lower hair density, inversely to Indian women. The same holds true with regard to the total surface of eyebrows, of a large variability (by about four times). Some criteria appear more individually dependent than ethnic‐specific, such as the oblique positioning, at the exception of Indian women with less oblique eyebrows. In all subjects, the criteria of both eyebrows (Left vs. Right) were found to be highly correlated (r > 0.7, P < 0.001).ConclusionThe present investigation brings new findings on a scarcely studied facial element, the morphologic features of which are, for most, ethnic‐dependent. As applied consequences, the results of the present work pave the road to better adapt adorning procedures of the eyebrows vis‐à‐vis ethnic and age specificities.
Assessing the impact of an aerial chronic urban pollution (UP) on some facial signs of differently‐aged Chinese men
Authors: Flament F. , Ye C. , Amar D. 
Published: July 2019

AbstractObjectiveTo assess the impact of an aerial chronic urban pollution (UP) on the severities of some facial signs of Chinese men living in two close but differently polluted Chinese cities.Materials and MethodsStandardized digital photographs were taken on 201 subjects from two cohorts of Chinese men (100 inhabitants of Baoding/very polluted and 101 inhabitants of Dalian/less polluted) differently aged (20–60 years) allowing a focus on 17 different facial signs. The latter were graded by 15 experts, using a clinical referential skin atlas. A questionnaire was filled by all subjects collecting their habits and uses with regard sun‐exposures and skincare products. A naïve panel of 80 Chinese women, of comparable ages, attributed a perceived age to each subject under blind conditions.ResultsThese confirm previous data obtained on Chinese women, with a similar protocol, i.e. that some facial signs show an increased severity in the more polluted city. However, changes in facial signs, with age, are of a different pattern according to gender. In Chinese men, most signs show early onsets with however low age‐related changes, inversely to those observed in women, at the exception of vascular disorders. Habits of sun‐exposures and uses of skincare product were found totally similar in both cohorts, reinforcing the specific role of UP in the progressive changes of facial signs. Similar to the results previously obtained on Chinese women, men living in a more polluted city were judged older than those living in a less polluted aerial environment.ConclusionThe present work confirms that a more severe UP increases the severities of some facial signs in Chinese men.