bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer
Authors: Deniz Çiğdem Damla , Gürbilek Mehmet , Koç Mehmet 
Published: May 2018

Abstract

Objective
Chemoradiotherapy (CRT) is a commonly used therapeutic modality. We investigated CRT effects on acute phase reactants (APRs). The aim of this study was to assess possible changes in APR levels during radiotherapy and to determine the usefulness of APRs as prognostic factors in patients with non-small cell lung cancer (NSCLC) and glioblastoma multiforme (GBM).

Methods
We prospectively evaluated 30 patients and 30 healthy controls. Plasma levels of APRs were measured. Post-CRT and pre-CRT levels were compared. Survival of patients were also followed up for a period of 3 years.

Results
In NSCLC patients, post-CRT albumin, transferrin (Trf), and ceruloplasmin (Cp) levels were significantly lower, and post-CRT ferritin (FER) levels were significantly higher, than their pre-CRT levels. In GBM patients, post-CRT Trf and prealbumin (Prealb) levels were significantly higher than pre-CRT levels. Pre-CRT C-reactive protein (CRP) and FER levels in NSCLC patients and Cp levels in GBM patients were associated with patient survival.

Conclusion
This study suggests that APRs may be useful for monitoring response to treatment during CRT in NSCLC and GBM patients. Bearing in mind their accessibility and clinical value, plasma CRP and FER in NSCLC patients and Cp in GBM patients can be considered candidate prognostic factors.
In vitro bioactivities and subacute toxicity study of O. basilicum, T. vulgaris and R. officinalis
Authors: Rehan Touseef , Tahira Riffat , Ullah Hanif , Tareen Usman , Rehan Tabassum , Anees Mariam , Murtaza Iram , Sultan Aneesa 
Published: May 2018

Abstract

Background

Ocimum basilicum, Thymus vulgaris, and Rosmarinus officinalis have been used for the treatment of different ailments for a historically long time but there have been no safety studies of these plants. Phytoconstituents of these plants were found to be good potential therapeutic agents which could be used in treatment regimens as a replacement of synthetic drugs if they are safe.

Experimental
Standard Folin ciocalteu reagent assay, aluminum chloride colorimetric assay and DPPH assay were employed to determine total phenolic, flavonoids and antioxidant activity, respectively. Broth microdilution method was used for investigation of synergistic effects of plant extracts with antibiotics. For toxicity assay, rats were treated with extracts of three plants at 1000 and 1500 mg/kg body weight.

Results

Ocimum basilicum extract showed highest total phenols, flavonoids, antioxidant and antibacterial activities. Thymus vulgaris extract caused hypertrophy of liver while Rosmarinus officinalis caused atrophy of spleen at both doses showing no significant histomorphological changes. Thymus vulgaris and O. basilicum extract significantly increased red blood cells, packed cell volume, hemoglobin and mean corpuscular volume at 1500 mg/kg body weight.

Conclusion

Ocimum basilicum, Thymus vulgaris and Rosmarinus officinalis have good phenolics and flavonoid content that shows antioxidant and antibacterial potential whilst having no evident toxic side effects on mammalian tissue and hematological parameters.
Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures
Authors: Imran Mohd. 
Published: May 2018

Abstract
The aim of this study was to determine the solubility of pyridazinone derivative 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) in different “polyethylene glycol 400 (PEG 400)+water” mixtures at temperatures “T=293.2 K to 313.2 K” and pressure “p=0.1 MPa”. The solubilities of PDP-6 were determined using an isothermal method and correlated with Apelblat, van’t Hoff and Yalkowsky–Roseman models. The maximum solubilities of PDP-6 in mole fraction were obtained in neat PEG 400 (8.46×10−2 at T=313.2 K). However, the minimum one was recorded in neat water (7.50×10−7 at T=293.2 K). Apparent thermodynamic analysis showed an endothermic dissolution of PDP-6 in all (PEG 400 water) mixtures. Based on the solubility data of the current study, PDP-6 has been considered as practically insoluble in water and soluble in PEG 400.
Inferring the Probability of the Derived vs. the Ancestral Allelic State at a Polymorphic Site
Authors: Keightley Peter D , Jackson Benjamin C 
Published: May 2018

Abstract
It is known that the allele ancestral to the variation at a polymorphic site cannot be assigned with certainty, and that the most frequently used method to assign the ancestral state—maximum parsimony—is prone to misinference. Estimates of counts of sites that have a certain number of copies of the derived allele in a sample (the unfolded site frequency spectrum, uSFS) made by parsimony are therefore also biased. We previously developed a maximum likelihood method to estimate the uSFS for a focal species using information from two outgroups while assuming simple models of nucleotide substitution. Here, we extend this approach to allow multiple outgroups (implemented for three outgroups), potentially any phylogenetic tree topology, and more complex models of nucleotide substitution. We find, however, that two outgroups and the Kimura two-parameter model are adequate for uSFS inference in most cases. We show that using parsimony to infer the ancestral state at a specific site seriously breaks down in two situations. The first is where the outgroups provide no information about the ancestral state of variation in the focal species. In this case, nucleotide variation will be underestimated if such sites are excluded. The second is where the minor allele in the focal species agrees with the allelic state of the outgroups. In this situation, parsimony tends to overestimate the probability of the major allele being derived, because it fails to account for the fact that sites with a high frequency of the derived allele tend to be rare. We present a method that corrects this deficiency and is capable of providing nearly unbiased estimates of ancestral state probabilities on a site-by-site basis and the uSFS.
Development of fats based on olive oil by chemical interesterification and its utilization in cookie production
Authors: Kaçar D. , Erinç H. , Sivri Özay D. 
Published: May 2018

Refined olive oil (ROO) was blended with tristearin (TS) and palm oil (PO) at two different ratios (ROO:TS:PO; 75:15:10 and 85:10:5) and chemical interesterification was performed in order to produce two interesterified fats (IF1 and IF2) with high unsaturated fatty acids and low trans fatty acids contents.
Solid fat content (SFC), slip melting point (SMP), and fatty acid composition were determined in IF1 and IF2; the values were compared to that of partially hydrogenated industrial cookie shortening (ICS). Higher SMP was measured in interesterified fats contaning 75% ROO (IF1) and lower SMP was obtained in interesterified fats containing 85% ROO (IF2). SFC values of interesterified ROO blended oils were lower than ICS. Interesterified fats were used for cookie production, and cookie quality parameters, including oxidation stability, were determined.
Results showed that hardness values of cookies were not affected by fat types and higher spread ratios and lighter colors were obtained. IF1 and IF2 had higher total oxidation values as compared to ICS.
Eye movements of online Chinese learners
Authors: Stickler Ursula , Shi Lijing 
Published: May 2018

Although online tutorials are becoming commonplace for language teaching, very few studies to date have provided insights into learners’ behaviours in synchronous online interactions from their own perspective. This study employs eyetracking technology to investigate ten learners’ attention during synchronous online language learning in a multimodal environment. The participants were learners of Chinese as a Foreign Language at beginners or lower-intermediate level. While learners took part in two different online activities, one focussing on reading, the other on interaction with others, their gaze focus was tracked, and in subsequent stimulated recall interviews the learners reflected on their engagement with the screen and their intentions while reading or speaking online. Our findings show that during reading tasks, when Pinyin transcriptions as well as Chinese characters were presented, all beginner and lower intermediate participants focused to some degree on the Pinyin. In the interactive task learners’ gaze was drawn to elements of the screen that were not immediately necessary for technical or linguistic reasons but that could be interpreted as containing social presence information, e.g. names listed and emoticons employed by other users.
Prospek Pengembangan Industri Kreatif Kulit Pari sebagai Pilot Project Usaha Kecil di Daerah Istimewa Yogyakarta
Authors: Rositasari Meida , Sahubawa Latif , Budhiyanti Siti Ari 
Published: May 2018

Industri kreatif merupakan kegiatan usaha yang fokus pada kreasi dan inovasi. Manajemen rantai pasok adalah jaringan perusahaan-perusahaan yang bekerjasama untuk menciptakan dan menghantarkan suatu produk ke tangan pemakai akhir. Penelitian bertujuan untuk mengkaji prospek pengembangan industri kreatif kulit pari di DIY sebagai pilot project usaha kecil di Indonesia.Metode pengumpulan data yang dipakai adalah observasi lapangan, wawancara dan kuesioner. Obyek penelitian adalah En’t Stingray Product, Fanri Collection dan Pari Radja. Data hasil penelitian diolah dan dianalisis dengan metode kuantitatif dan kualitatif, selanjutnya digeneralisasisecara deskriptif. Hasil penelitian menunjukkan bahwa<br />bahan baku kulit pari tersamak 75% berasal dari supplier di Yogyakarta dan tersedia secara kontinu. Sarana dan prasarana usaha pengolahan produk cukup memadai. Produk yang dihasilkan berupa dompet pria dan<br />wanita, gantungan kunci, tas, ikat pinggang dan gelang. Jaringan pemasaran produk kulit pari En’t Stingray Product di Yogyakarta dan Jawa Tengah, Fanri Collection di Yogyakarta, Jakarta, Bandung, Surabaya, Pari<br />Radja di seluruh Indonesia, Malaysia, Singapura, Jepang dan Amerika. Kelembagaan rantai pasok produk kulit terdiri dari supplier kulit segar, supplier kulit tersamak, pengrajin, reseller, konsumen. Berdasarkan hasil<br />analisis kelayakan finansial, diketahui bahwa NPV En’t Stingray Product yaitu Rp 75.312;Fanri Collection Rp 2.498.023; Pari RadjaRp 4.715.503 lebih besar dari nol. Prospek pengembangan industri produk kulit pari<br />yang mencakup rantai pasok dan kelayakan usaha memberikan dampak yang positif terhadap pengembangan dan keberlanjutan usaha.<br /><br />
Construction Technology and Innovation Research of Municipal Civil Engineering
Authors: FU Xiangliang , LIU Mingming , WANG Xingsheng , YIN Jian , SU Ping 
Published: May 2018

Since the reform and openning-up, relationship between construction industry and economic market in China has had fundamental changes, and has laid good foundation for updating and reforming of domestic architectural technologies influenced by continuous increase of total market investment. In the construction process of architectural engineering project, as the basic structure of the entire building, theoretical system of construction technologies in civil engineering should be deeply studied in the future to fully satisfy strategic requirements of modern construction system, innovation of original and core technologies should be emphasized to improve civil engineering technology and construction means and play a positive role for maximum construction benefits of civil engineering, and it has great practical significance. The article has made all-round representation on authority and importance of construction technology innovation of civil engineering architecture from the global perspective, discussed and exchanged construction technology features of civil engineering in current period, continuously deepened innovation and reforming of construction technology of civil engineering to effectively facilitate improvement of natures of the building based on summary of construction experience of engineering oriented with technical innovation.
On the innovation and development of civil engineering construction technology
Authors: Wang Jue , Xie Zuozheng , Zhang Bin , Tian Liqiang , Xu Liang 
Published: May 2018

With the rapid development of China's market economy, to a certain extent, the market scale of building engineering has been widened. At the same time, it also brings convenience to people's work and life. Therefore, people put forward higher standards for the construction quality of building engineering. In building engineering construction, civil engineering construction technology is the core part, directly affecting the construction quality of building engineering.
USULAN PERBAIKAN POSTUR KERJA OPERATOR PROSES PRODUKSI BATIK CAP DI BATIK PUTRI MULYO DENGAN METODE VISUAL MANAGEMENT
Authors: Rosifah Anita , Susmartini Susy , Iftadi Irwan 
Published: May 2018

<p><em>Observations made at work stations </em><em>of </em><em> batik cap</em><em> production,</em><em> there are still some working conditions that are not appropriate on the</em><em>ir</em><em> worker, one of which is unnatural posture. Unusual work postures that can trigger the occurrence of pain complaints such as musculoskeletal disorders (musculoskeletal disorders). Often unwittingly</em><em>,</em><em> batik workers work with positions or postures that have health risks such as musculoskeletal disorders (MSDs). Based on the observation seen that at the work station batik production there are </em><em>some </em><em>problems related work methods. Therefore, to improve which work station needs to be repaired, it is necessary to do risk assessment of batik production station work posture using Visual Management approach.</em></p><p><em> </em><em>The Visual Management approach in this study uses the ergonomic analysis method for the whole body of REBA (Rapid Entire Body Assessment) and OWAS (Ovako Working Posture Analysis System), upper limb RULA (Rapid Upper limb Assessment) and OCRA checklist and by adding some aspects Associated with overload and repetitiveness in the OCRA checklist and OWAS.</em></p><em> Based on the assessment of work posture by visual management method, the result of OES value shows 3 processes with OES value ≤ 0.4 with accepted operational status and 2 process with OES value is in the range 0.4 &lt;OES ≤ 0.5, with operational status becomes' necessary further investigation, Changes may be required</em>
Perbaikan Tingkat Kebisingan pada Ruang Produksi Yessy’s Collection dengan Pendekatan Ergonomi
Authors: Aviv Afgan Suffan , Suhardi Bambang , Laksono Pringgo Widyo 
Published: May 2018

<p><em>Implementation of ergonomics is generally a design or redesign. One of them may include the design of the physical work environment. Ergonomic work environment conditions are provide comfort and security for workers. Physical environmental factors that can affect the comfort and safety of noise level. A good physical work environment will increase work capability or labor productivity. In a work environment, workload assessment can also be carried out to measure worker conformity and comfort. Workload assessment is carried out simultaneously with measurement of noise level . </em></p><p><em>Whose problematic noise, the industry is located in Tawangsari RT 03 RW 34 Mojosongo, Jebres, Surakarta named Yessy's Collection. Measurement of noise level to improve worker comfort, so that productivity increases. The methode used is measurement using 4 in 1 Environment on sound level meter function illustrated with Software Surfer 11.</em></p><em> The noise level measurement results are below the specified threshold value except at 1 coordinate in swabing station (stasiun penyesekan),that is at above threshold value. To proposed improvements as noise control is engineering control, administrative control and use of PPE</em>
Process Based Approach towards Students’ Creativity in Writing English Paragraph
Authors: Qomariyah Siti Syafi’atul , Permana Dira 
Published: May 2018

The research entitled “Process based Approach towards Students’ English Paragraph Writing Ability” aims to discover whether or not Process based Approach is effective or not towards students’ English paragraph writing ability. This was a queasy-experimental research with pretest-posttest control group design. The population of the study was the fourth semester students of Writing subject of English Department at Language and Art Education Faculty of IKIP Mataram in the academic year of 2016/2017. Samples of the study were IV-E and IV-F taken through cluster random sampling technique. To determine the experimental and control class, lottery was used. Instrument of the research was paragraph writing test. Techniques of analyzing data were descriptive and inferential statistic analysis. Data of samples were in normal distribution since the value of sig (081) was higher than the value of alpha (0.05). Data of samples were also homogeneous as the value of sig (012) was higher than the value of alpha (0.05). Based on the result of t-test of two-tailed independent samples, it was found that the value of sig (196) was lower than the value of alpha at the level of significance (0.05). It means that Process based Approach was not effective towards students’ English paragraph writing ability.
Mobile-Assisted Language Learning (MALL) in Indonesian Islamic Higher Education
Authors: Yudhiantara Rully Agung , Saehu Andang 
Published: May 2018

Mobile phone use has been studied in its connection with foreign language learning by many researchers concerned in Mobile Assisted language learning (MALL) for more than a decade. In Indonesian Islamic higher education context, the issues of MALL has not been discussed extensively. To respond to this need, this study was aimed at investigating the following research question: 1) How do students use their mobile phone to learn English Monolingual Dictionary (EMD) application?; 2)How do students use their mobile phone to support English language learning?. This study employed the qualitative method using case study. To collect data, this study applied observation to find out students’ engagement in using the mobile phone for learning EMD application. Students participated in this study were 40 students. Findings showed that students were able to use the mobile phone to use EMD application in English language learning (ELL). They demonstrated skill in operating EMD application which was realized in their knowledge concerning, pronunciation, grammar and meaning information when searching a particular word. In addition, there were many features that students seized from the mobile phone for English language learning. They used audio feature to operate EMD from mobile phone to boost listening skill. Their mobile phone facilitated them to record video project presenting their vocabulary learning. These activities could be done by their mobile phone existence as an introductory effort toward MALL implementation in ELL in Islamic Higher education.
MALT Lymphoma, Stress Ulcer and Cholinergic Nerves from the Viewpoint of Bilateral and Unilateral Truncal Vagotomy and Substance P
Authors: Kodama Yosuke , Sasaki Kazuki , Murasato Futa , Overby Anders , Takahashi Shinichi , Murayama Somay Y. , Matsui Hidenori , Nakamura Masahiko 
Published: May 2018

Background:
Vagal nerve plays an important role in the stomach function. The cholinergic nerves are
the most abundantly distributed nerves in the gastric tissue. It has recently been reported that the vagal nerve is
significantly related to both gastric cancer development and progression. However, its relation to the mesenchymal
tumor, including MALT lymphoma, is not known. In this study, we investigated the effect of unilateral truncal
vagotomy on gastric MALT lymphoma development by using Helicobacter heilmannii-infected mouse model
as well as that of bilateral truncal vagotomy on stress-induced ulcer formation.

Methods:
In the first part of this study, the distribution of the cholinergic nerves in the rat gastric mucosa and the
effect of bilateral truncal vagotomy, as well as various kinds of agents acting on autonomic nerves in rats, were
investigated by the histochemical and macroscopic method. In the second part, we employed MALT lymphoma
formation in C57BL/6NCrl mice that were infected with Helicobacter heilmannii. A total of 38 infected mice
underwent unilateral vagotomy under microscopy. The mice were randomized into 4 groups from which samples
were collected; 2, 3, 4 and 6 months after infection. Both the anterior and posterior sides of the stomachs were
sampled from each mouse for pathological and immunohistochemical analyses.

Results:
The bilateral truncal vagotomy significantly suppressed the restraint-induced gastric ulcer formation in
rats, while bethanechol, and 6-hydroxydopamine led to an increase of the gastric ulcer formation. In the unilateral
truncal vagotomy study using MALT lymphoma, the thickness of the gastric mucosa was reduced in the
vagotomized side compared to the non-vagotomized side. Furthermore, the gastric MALT lymphoma was more
prominently found in the vagotomized anterior side of stomach compared with that in the non-vagotomized posterior
side of stomach. Substance P-immunoreactive nerves markedly increased surrounding the MALT lymphoma
and the neurokinin-1 receptor immunoreactive lymphocytes increased within the MALT lymphoma in the
vagotomized side. In conclusion, vagotomy enhanced gastric MALT lymphoma development possibly through
the substance P-neurokinin-1 receptor pathway.
Coreceptor Tropism and Maraviroc Sensitivity of Clonally Derived Ethiopian HIV-1C Strains Using an in-house Phenotypic Assay and Commonly Used Genotypic Methods
Authors: Kalu Amare Worku , Telele Nigus Fikrie , Aralaguppe Shambhu G , Gebre-Selassie Solomon , Fekade Daniel , Marrone Gaetano , Sonnerborg Anders 
Published: May 2018

Objectives:Genotypic Tropism Testing (GTT) tools are generally developed based on HIV-1 subtype B (HIV-1B) and used for HIV-1C as well but with a large discordance of prediction between different methods. We used an established phenotypic assay for comparison with GTT methods and for the determination of in vitro maraviroc sensitivity of pure R5-tropic and dual-tropic HIV-1C.Methods:Plasma was obtained from 58 HIV-1C infected Ethiopians. Envgp120 was cloned into a luciferase tagged NL4-3 plasmid. Phenotypic tropism was determined by in house method and the V3 sequences were analysed by five GTT methods. In vitro maraviroc sensitivity of R5-tropic and dual-tropic isolates were compared in the TZMbl cell-line.Results:The phenotypes were classified as R5 in 92.4% and dual tropic (R5X4) in 7.6% of 79 clones. The concordance between phenotype and genotype ranged from 64.7% to 84.3% depending on the GTT method. Only 46.9% of the R5 phenotypes were predicted as R5 by all GTT tools while R5X4 phenotypes were predicted as X4 by four methods, but not by Raymond’s method. All six tested phenotypic R5 clones, as well as five of six of dual tropic clones, showed a dose response to maraviroc.Conclusion:There is a high discordance between GTT methods, which underestimates the presence of R5 and overestimates X4 strains compared to a phenotypic assay. Currently available GTT algorithms should be further improved for tropism prediction in HIV-1C. Maraviroc has an in vitro activity against most HIV-1C viruses and could be considered as an alternative regimen in individuals infected with CCR5-tropic HIV-1C viruses.