bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm
Authors: Wang ShaoPeng , Li JiaRui , Sun Xijun , Zhang Yu-Hang , Huang Tao , Cai Yudong 
Published: December 2018

Background:
As a newly uncovered post-translational modification on the
ε-amino group of lysine residue, protein malonylation was found to be involved in
metabolic pathways and certain diseases. Apart from experimental approaches, several
computational methods based on machine learning algorithms were recently proposed to
predict malonylation sites. However, previous methods failed to address imbalanced data
sizes between positive and negative samples.

Objective:
In this study, we identified the significant features of malonylation sites in a
novel computational method which applied machine learning algorithms and balanced data
sizes by applying synthetic minority over-sampling technique.

Method:
Four types of features, namely, amino acid (AA) composition, position-specific
scoring matrix (PSSM), AA factor, and disorder were used to encode residues in protein
segments. Then, a two-step feature selection procedure including maximum relevance
minimum redundancy and incremental feature selection, together with random forest
algorithm, was performed on the constructed hybrid feature vector.

Results:
An optimal classifier was built from the optimal feature subset, which featured an
F1-measure of 0.356. Feature analysis was performed on several selected important features.

Conclusion:
Results showed that certain types of PSSM and disorder features may be
closely associated with malonylation of lysine residues. Our study contributes to the
development of computational approaches for predicting malonyllysine and provides
insights into molecular mechanism of malonylation.
Long-Term Outcome of Acute Coronary Syndromes in Patients on Chronic Oral Anticoagulants: Data from the EPICOR Study
Authors: Stepinska Janina , Wojtkowska Izabela , Annemans Lieven , Danchin Nicolas , Pocock Stuart J. , de Werf Frans Van , Medina Jesús , Bueno Hector 
Published: December 2018

Objective:
To analyze characteristics, management and outcomes of patients with acute
coronary syndromes (ACS) receiving chronic oral anticoagulant (OAC) therapy enrolled in the EPICOR
(long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients)
prospective, international, observational study of antithrombotic management patterns in ACS survivors
(NCT01171404).

Methods:
This post-hoc analysis evaluated the association between OAC use at baseline (OACb) and
time from hospital admission to percutaneous coronary intervention (PCI) (tHA-PCI), pre-PCI thrombolysis
in myocardial infarction (TIMI) 3 flow, stent type, length of hospitalization, and clinical endpoints;
death, non-fatal MI, and non-fatal stroke, a composite of these ± bleeding, over 2 years’ followup.

Results:
Of 10,568 ACS patients, 345 (3.3%) were on OACb (non-ST-segment elevation ACS [NSTEACS],
n=268; ST-segment elevation MI [STEMI], n=77). OACb patients were older with more comorbidities.
In NSTE-ACS OACb patients, tHA-PCI was longer (median 57.4 vs. 27.8 h; p=.008), and
TIMI 3 flow rarer (26.0 vs. 33.5%; p=0.035). OACb patients had longer mean hospital stay (NSTEACS:
8.9 vs. 7.6 days; p<0.001; STEMI: 9.5 vs. 7.8 days; p=0.015), and higher rates of the composite
endpoint (NSTE-ACS: 16.8 vs. 8.8%; p<0.0001; STEMI: 23.4 vs. 5.9%; p<0.0001). Bleeding events
were more common with OACb (NSTE-ACS: 6.0 vs. 3.3%; p=0.01; STEMI: 6.5 vs. 2.8%; p=0.04).

Conclusion:
At 2-years, OACb use was associated with an increased risk of cardiovascular and bleeding
events in STEMI and NSTE-ACS. NSTE-ACS patients on OACb experienced prolonged time to
intervention, lower rates of TIMI 3 flow and longer hospitalization.
Vitamin D and Spondyloarthritis: Review of the Literature
Authors: Crotti Chiara , Becciolini Andrea , Biggioggero Martina , Favalli Ennio Giulio 
Published: December 2018

Background:
Spondyloarthritides (SpAs) encompass heterogeneous diseases sharing similar genetic background, pathogenic mechanisms, and phenotypic features. Vitamin D is essential for calcium metabolism and skeletal homeostasis. Some recent evidences reported supplemental functions of vitamin D, such as modulation of inflammatory reactions.

Objective:
To analyze published data about a possible association between vitamin D and SpAs.

Results:
Vitamin D could play a role in immune reactions, influencing both immune and adaptive response. Vitamin D deficiency is more frequent in SpAs than in general population: an active and more severe disease infers patients’ mobility and reduces sunlight exposure. Quiescent inflammatory bowel disease, frequently associated with SpAs, could worsen vitamin D deficiency. All the parameters related to UVB exposure are the most important determinants for vitamin D status and need to be considered evaluating the vitamin D levels in SpAs.
Apart from musculoskeletal problems, patients affected by SpAs frequently suffer from other comorbidities, especially cardiovascular diseases and osteoporosis, and vitamin D status could have a relevance in this field. Bone is involved in SpAs with a dualistic role, coexisting trabecular bone resorption and new bone formation.
It seems rational to monitor vitamin D levels in SpA subjects and to target it to global health threshold.

Conclusion:
Literature data were not completely in agreement about a possible relation between poor vitamin D status and onset or worse disease course of SpAs. In fact, these results come from cross-sectional studies, which affect our ability to infer causality. Therefore, large, randomized controlled trials are needed.
Chemo-Diversity of Antibacterial Anthraquinones from the Roots of Morinda morindoides
Authors: Moroh Jean-Luc Aboya , Fleury Yannick , Coulibaly Adama , Labia Roger , Leguérinel Ivan 
Published: December 2018

Background:
Morinda morindoides (Baker) (Rubiaceae) is a medicinal plant with antimicrobial
properties currently used in Côte d'Ivoire and other countries. These properties have been described
but most of the studies are dealing with crude extracts.

Objective:
The chemical structures of the bioactive compounds extracted from Morinda morindoides
roots have been characterized.

Methods:
The root extracts were analyzed by using HPLC. Fourteen fractions were detected among
which 11 compounds have been structurally identified by using a combination of 1H-NMR and 13CNMR
and LC-HRMS methodologies.

Results:
All these compounds belong to anthraquinone family. The antibacterial activity of the
eleven compounds was tested against six strains of microorganisms with ofloxacin as standard (two
Gram-negative bacteria, two Gram-positive bacteria and two yeasts). The Minimal Inhibitory Concentrations
recorded, varies from 8 to 128 μg / ml. Staphylococcus aureus was the most susceptible
organism.

Conclusion:
We highlight the chemo-diversity of the antibacterial anthraquinones in the roots of
Morinda morindoides.
Nanohybrids of Dendrimers and Carbon Nanotubes: A Benefaction or Forfeit in Drug Delivery?
Authors: Jain Keerti 
Published: December 2018

Introduction:
Nanomaterials are emerging as a fascinating delivery systems being explored
for the delivery of different bioactives including drug, diagnostic agents and genetic materials
etc. Among these nanomaterials dendrimers and Carbon Nanotubes (CNTs) are being investigated
for various biomedical applications. Although both of these nanomaterials have shown great
potential in drug delivery yet their promising clinical applications are still suspected due to problems
like toxicity, dispersibility etc. Scientists have been investigating the potential of nanohybrids
comprising of dendrimers and nanotubes for biomedical applications. Few reports are also available
on the toxicological profile of CNTs and dendrimers nanohybrids.

Conclusion:
The results of these investigations suggest two possibilities, first, hybrids of CNTs
and dendrimers could suppress each other’s demerits while synergizing the potentials; second, prospective
toxicity of nanohybrids on which different reports have discrimination in results. Future
biomedical applications of CNTs-dendrimers nanohybrids require a thorough investigation on their
toxicity and biological interactions.
Sujeitos performativos do jurídico II: sobre narrativas de raça e gênero para uma releitura do povo como categoria de uma democracia radical
Authors: Magalhães Gomes Camilla De 
Published: December 2018

RESUMO:Guiado por um propósito geral de introduzir a corporeidade na teoria jurídica, este artigo serve como parte de uma investigação sobre as possibilidades de uma teoria do humano no Direito que seja expansiva. Para isso, utiliza-se das matrizes teóricas da performatividade e da decolonialidade. Essa leitura permite tanto reconhecer o Direito como violência, quanto nele encontrar possibilidades de uso de sua linguagem para construir sentidos expansivos. E é com isso em mente que um dos institutos que falam do humano no Direito é analisado: o povo. Quem é o povo? Quem é essa instituição definida no ato de promulgação da Constituição? E quem não é o povo – ou ao menos ainda não? Proponho, então, ler o povo como ato de fala performativo e, ao fazer essa leitura, permitir que as corporalidades antes produzidas como abjetas agora sejam nossa forma de reinscrever o sentido do humano no Direito. ABSTRACT:Guided by a general purpose of introducing corporeity into Legal Theory, this article serves as part of an investigation of the possibilities of a theory of the human in the Law that is expansive. For this, the theoretical framework of performativity and decoloniality are used. This reading allows both to recognize Law as violence, but also to find possibilities of using its language to build expansive senses. And it is with that in mind that one of the institutes that speak of the human in Law is analyzed: the people. Who are the people? Who is this institution defined in the act of the promulgation of the Constitution? And who is not the people – or at least not yet? I propose, therefore, to read the people as a performative speech act, and in doing this reading allow corporealities formerly produced as abject now be our way of reintroducing the meaning of the human in Law.
Patterns of Beverages Consumed and Risk of Incident Kidney Disease
Authors: Rebholz Casey M. , Young Bessie A. , Katz Ronit , Tucker Katherine L. , Carithers Teresa C. , Norwood Arnita F. , Correa Adolfo 
Published: December 2018

Background and objectives
Selected beverages, such as sugar-sweetened beverages, have been reported to influence kidney disease risk, although previous studies have been inconsistent. Further research is necessary to comprehensively evaluate all types of beverages in association with CKD risk to better inform dietary guidelines.

Design, setting, participants, & measurements
We conducted a prospective analysis in the Jackson Heart Study, a cohort of black men and women in Jackson, Mississippi. Beverage intake was assessed using a food frequency questionnaire administered at baseline (2000–2004). Incident CKD was defined as onset of eGFR<60 ml/min per 1.73 m2 and ≥30% eGFR decline at follow-up (2009–13) relative to baseline among those with baseline eGFR ≥60 ml/min per 1.73 m2. Logistic regression was used to estimate the association between the consumption of each individual beverage, beverage patterns, and incident CKD. Beverage patterns were empirically derived using principal components analysis, in which components were created on the basis of the linear combinations of beverages consumed.

Results
Among 3003 participants, 185 (6%) developed incident CKD over a median follow-up of 8 years. At baseline, mean age was 54 (SD 12) years, 64% were women, and mean eGFR was 98 (SD 18) ml/min per 1.73 m2. After adjusting for total energy intake, age, sex, education, body mass index, smoking, physical activity, hypertension, diabetes, HDL cholesterol, LDL cholesterol, history of cardiovascular disease, and baseline eGFR, a principal components analysis–derived beverage pattern consisting of higher consumption of soda, sweetened fruit drinks, and water was associated with significantly greater odds of incident CKD (odds ratio tertile 3 versus 1 =1.61; 95% confidence interval, 1.07 to 2.41).

Conclusions
Higher consumption of sugar-sweetened beverages was associated with an elevated risk of subsequent CKD in this community-based cohort of black Americans.
FINANCIAL AND ECONOMIC ANALYSIS OF INTERCROPPING MAIZE AND SOYBEAN ON IMMATURE OIL PALM
Authors: Agustira Muhammad Akmal , Lubis Ilham , Listia Eka , Akoeb Erwin Nyak , Harahap Iman Yani , Lubis M. Edwin S. 
Published: December 2018

Maize and soybean can be planted for intercropping on immature oil palm, however its financial and economycal aspects have not been widely studied. This study was aimed to analyze the financial and economic aspects of intercropping of maize and soybean on immature oil palm, level of land use efficiency, and comparison of efficiency between monolculture and intercropping system. The study located in Sorolangun Experimental Station, District of Sorolangun, Jambi. Methods used in the study were farming business analysis, Revenue Cost Ratio (RCR), Return on Investments (ROI), Land Equivalent Ratio (LER), and Land Equivalent Optimize Ratio (LOER). The results showed that maize had a profit level of Rp 9,676,564/ha/growing season, RCR 1.76; ROI 188.28% (three growing seasons per year), while soybean had a profit level of Rp 4,059,352/ha/growing season, RCR 1.51 and ROI 75.22% (three growing seasons per year). Based on these results, intercropping of maize and soybean on immature oil palm are economically and financially feasible. For the land use efficiency, corn LER value for corn and soybean was 0.95 and 0.85, respectively, showing that yield of maize and soybean from intercropping system (effective land area of ​​7,200 m2 per ha of oil palm area) was 95% and 85% when compared to monoculture system. The LOER value of corn and soybeans per ha was 1.32 and 1.18, respectively, which showed that corn and soybeans growing on intercropping system with immature oil palm were more efficient than monoculture system at the same size of land. Based on those comparative analysis of economic values, financial, and land use efficiency, corn was a better alternative crop for intercorpping on immature oil palm than soybean.
POTENSI BEBERAPA GULMA SEBAGAI TANAMAN PENUTUP TANAH DI AREA TANAMAN KELAPA SAWIT MENGHASILKAN
Authors: Asbur Yenni , Rambe Rahmi Dwi Handayani , Purwaningrum Yayuk , Kusbiantoro Dedi 
Published: December 2018

Pengelolaan tanaman penutup tanah merupakan salah satu merupakan salah satu teknik konservasi tanah dan air di perkebunan kelapa sawit. Penelitian ini bertujuan untuk mempelajari potensi beberapa gulma sebagai tanaman penutup tanah di perkebunan kelapa sawit menghasilkan. Penelitian dilaksanakan di perkebunan kelapa sawit rakyat umur 20 tahun di Desa Namorambe Kecamatan Namorambe, Kabupaten Deli Serdang, Sumatera Utara dari Maret sampai Juni 2017. Penelitian disusun menggunakan rancangan acak kelompok satu faktor. Empat spesies gulma (N. biserrata, A. gangetica, P. conjugatum, dan A. conyzoides) dijadikan sebagai perlakuan, setiap perlakuan diulang tiga kali. Hasil penelitian menunjukkan bahwa N. biserrata, A. gangetica, P. conjugatum, dan A. conyzoides berpotensi digunakan sebagai tanaman penutup tanah di area kelapa sawit menghasilkan. Keempat spesies tersebut mudah diperbanyak, cepat menutup lahan (8-12 minggu setelah tanam), memproduksi daun dan cabang cukup banyak, dan cukup mengandung unsur hara di dalam jaringan tanamannya. Kandungan N, P, K, dan C organik tertinggi berturut-turut terdapat pada N. biserrata (4,02% N), P. conjugatum (0,31% P), A. gangetica (2,41% K), dan A. conyzoides (37,23% C-organik).
Трансдисциплинарность как направление развития современного градостроительства
Authors: Bocharov Yuri P. , Zheblienok Mikhail A. , Zheblienok Natalia N. 
Published: December 2018

Статья посвящена вопросу развития принципов дисци­плинарного взаимодействия в градостроительстве. Перечень дисциплин, составляющих научную основу градостроитель­ства, часто становился предметом исследования отечествен­ных авторов, но принцип организации взаимодействий и обеспечение междисциплинарной иерархии имеющимися исследованиями почти не затронуты. Авторский коллектив систематизировал отечественные модели организации дисциплинарного взаимодействия в градостроительстве. Выделены важнейшие этапы эволюции дисциплинарных вза­имодействий, которые по аналогии с зарубежной практикой названы «многодисциплинарный» - «междисциплинарный» и «трансдисциплинарный».
«Многодисциплинарная» модель интеграции опирается на возможности суммирования знаний из различных на­учных областей специалистом-градостроителем. Эта модель предполагает крайне ограниченное количество дисциплин и остро ставит вопрос физической возможности освоения всего круга знаний одним специалистом. В дальнейшем эта модель была усовершенствована и во всем мире получила распро­странение идея «междисциплинарной» интеграции, которая предполагает существование нескольких профилей в про­фессии градостроителя. Дисциплинарный синтез реализуется за счет формирования междисциплинарных исследований, появлением новых пограничных областей научного знания.
В настоящий момент «трансдисциплинарная» модель определена как наиболее актуальная. На основании модели «трансдисциплинарных» взаимодействий предложена кон­цепция современной структуры градостроительства. Систему градостроительных знаний предлагается рассматривать как часть системы общечеловеческих знаний, сконцентрирован­ную вокруг сложного гетерогенного объекта - искусственной среды обитания. В этом случае границы градостроительного знания трактуются как адаптирующиеся в зависимости от ус­ловий конкретного объекта градостроительной деятельности. Концепция позволяет учесть динамичный характер постоянно расширяющего перечня научных дисциплин, причисляемых к системе градостроительных знаний, а также принимает во внимание разнообразные формы активности (участие жите­лей, общественных организаций, инициативы представителей разных уровней власти), которые в современном мире со­ставляют весомую часть градостроительства[1].
[1] Исследование выполнено в рамках Государственной программы Российской Федерации «Развитие науки и технологий» на 2013-2020 годы по Плану фундаментальных научных исследований Минстроя России и РААСН, тема №5.1.6/4.2.13.
«Лахта Центр»: автоматизированный мониторинг деформаций несущих конструкций и основания
Authors: Travush Vladimir I. , Shakhramanyan Andrey M. , Kolotovichev Yury A. , Shakhvorostov Alexey I. , Desyatkin Mikhail O. , Shulyatyev Oleg A. , Shulyatyev Stanislav O. 
Published: December 2018

Многофункциональный комплекс МФК «Лахта Центр» - масштабный проект общественно-деловой застройки Приморского района Санкт-Петербурга. В состав комплекса вошли три уникальных сооружения: сверхвысокая Башня, большепролётные Многофункциональное здание (МФЗ) и входная Арка[1], объединённые общей стилобатной частью. При возведении объектов комплекса было задействовано множество инновационных строительных технологий, применены нестандартные проектные решения.
В соответствии с действующими нормативными документами для обеспечения безопасности возведения и эксплуатации уникальных зданий в рамках проведения научно-технического сопровождения (НТС) строительства был организован комплекс мероприятий по постоянному мониторингу напряжённо-деформированного состояния (НДС) конструкций МФК.
Основная цель проведения мониторинга - минимизировать вероятность возникновения аварийных ситуаций, вызванных неопределённостями в работе несущих конструкций здания и грунтов основания.
В статье приводится общая информация о проектных и организационных решениях по внедрению системы автоматизированного мониторинга НДС конструкций Башни МФК «Лахта Центр». Даны подробные сведения об архитектуре и топологии системы, описаны применяемое оборудование, методика проведения измерений, программное обеспечение и регистрируемые с его помощью параметры напряжённодеформированного состояния сооружений.
Обобщён опыт проектирования, монтажа, наладки и эксплуатации системы мониторинга деформаций несущих конструкций Башни во время её возведения. Особое внимание уделено результатам сопоставления расчётов ряда ответственных конструкций с данными инструментального мониторинга. Отмечены проблемы, неизбежно возникающие при интерпретации результатов мониторинга, предложены пути их решения.
Особо подчёркнута ценность данных, предоставляемых системами автоматизированного мониторинга, для повышения качества научно-технического сопровождения строительства и калибровки компьютерных моделей основания, фундамента и несущих конструкций зданий.

[1] В статье приняты проектные написания названия МФК и составляющих его объектов.
RANCANG BANGUN SISTEM HIDROLIK PADA MERIAM ARTILERI PERTAHANAN UDARA (57 MM) RETROFIT
Authors: Pakki Gunawan , Kusnadi Kusnadi , Darmanto Ardyanto , Gunarko Gunarko , Aristha Aristha 
Published: December 2018

Meriam 57 mm Retrofit merupakan salah satu alat utama sistem persenjataan (alutsista) yang dimiliki satuan Batalyon Arhanudse untuk menghalau serangan udara. Pada pergeseran meriam dari pangkalan menuju ke medan latihan/tempur atau sebaliknya, perlu dilakukan perubahan sikap angkut pada meriam terlebih dahulu. Perubahan sikap tempur ke sikap angkut pada meriam masih menggunakan pompa manual, yaitu mengayunkan tuas pompa manual untuk mengalirkan minyak hidrolik dari tangki ke silinder bogie. Piston di dalam silinder bogie akan naik sehingga terjadilah perubahan dari sikap tempur ke sikap angkut. Penggunaan pompa manual ini kurang efektif karena selain menguras tenaga, waktu pemompaan juga relatif lama ± 1 menit. Berdasarkan hal tersebut diatas, telah dirancang sistem hidrolik untuk perubahan sikap angkut pada meriam tersebut yang terdiri dari gear pump, hydraulic hose, katup-katup, inverter, motor listrik AC. Dengan memanfaatkan sumber listrik dari baterai meriam yang diubah dari arus DC menjadi arus AC oleh inverter sehingga menggerakkan motor listrik. Ketika motor listrik dihidupkan gear pump ikut berputar karena satu poros dengannya. Gear pump akan menghisap minyak dari tangki dan memompanya kedalam silinder bogie melalui hydraulic hose dan katup-katup yang terpasang. Sehingga terjadilah perubahaan sikap angkut yang lebih efesien tenaga dan waktu. Kata kunci : meriam, silinder bogie, gear pump, motor listrik.
Tooth Mineralization: A Technical Note on the Moorrees-Fanning-Hunt Standards
Authors: Harris Edward F. , Buck Andrea L. 
Published: December 2018

One of the largest, longitudinal studies of tooth mineralization is that described by Moorrees, Fanning and Hunt (J Dent Res, 1963) based on children growing up in Boston, Massachusetts, and Yellow Springs, Ohio. This short communication provides tables of the means and standard deviations, by sex, in order to make the data more accessible and usable than the graphic form of the information in the original article. Characteristics of the study and applications are discussed.
Fourth Molars in the Anthropoidea
Authors: Swindler Daris R. 
Published: December 2018

Fourth molars are not common in the anthropoidea. Orangutans possess the highest frequencies (7-13%) while many genera in the suborder lack the fourth molars. A review of the incidence of M4’s in the Anthropoidea is presented and a description of the ontogeny of M4 in Macaca nemestrina is described and offered as an explanation of the development of M4’s in this taxon.