bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Authors: Hellwege Jacklyn N. , Velez Edwards Digna R. , Giri Ayush , Qiu Chengxiang , Park Jihwan , Torstenson Eric S. , Keaton Jacob M. , Wilson O. D. , Robinson-Cohen Cassianne , Chung Cecilia P. , Roumie Christianne L. , Klarin Derek , Damrauer Scott M. , DuVall Scott L. , Siew Edward , Akwo Elvis A. , Wuttke Matthias , Gorski Mathias , Li Man , Li Yong , Gaziano J. Michael , Wilson Peter W. F. , Tsao Philip S. , O’Donnell Christopher J. , Kovesdy Csaba P. , Pattaro Cristian , Köttgen Anna , Susztak Katalin , Edwards Todd L. , Hung Adriana M. 
Published: August 2019

AbstractChronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide Association Study of eGFR in 280,722 participants of the Million Veteran Program (MVP), with replication in 765,289 participants from the Chronic Kidney Disease Genetics (CKDGen) Consortium. We identify 82 previously unreported variants, confirm 54 loci, and report interesting findings including association of the sickle cell allele of betaglobin among non-Hispanic blacks. Our transcriptome-wide association study of kidney function in healthy kidney tissue identifies 36 previously unreported and nine known genes, and maps gene expression to renal cell types. In a Phenome-Wide Association Study in 192,868 MVP participants using a weighted genetic score we detect associations with CKD stages and complications and kidney stones. This investigation reinterprets the genetic architecture of kidney function to identify the gene, tissue, and anatomical context of renal homeostasis and the clinical consequences of dysregulation.
Hierarchical self-assembly of organic heterostructure nanowires
Authors: Zhuo Ming-Peng , Wu Jun-Jie , Wang Xue-Dong , Tao Yi-Chen , Yuan Yi , Liao Liang-Sheng 
Published: August 2019

AbstractOrganic heterostructures (OHSs) integrating the intrinsic heterostructure characters as well as the organic semiconductor properties have attracted intensive attention in material chemistry. However, the precise bottom-up synthesis of OHSs is still challenging owing to the general occurrence of homogeneous-nucleation and the difficult manipulation of noncovalent interactions. Herein, we present the rational synthesis of the longitudinally/horizontally-epitaxial growth of one-dimensional OHSs including triblock and core/shell nanowires with quantitatively-manipulated microstructure via a hierarchical self-assembly method by regulating the noncovalent interactions: hydrogen bond (−15.66 kcal mol−1) > halogen bond (−4.90 kcal mol−1) > π-π interaction (−0.09 kcal mol−1). In the facet-selective epitaxial growth strategy, the lattice-matching and the surface-interface energy balance respectively facilitate the realization of triblock and core/shell heterostructures. This hierarchical self-assembly approach opens up avenues to the fine synthesis of OHSs. We foresee application possibilities in integrated optoelectronics, such as the nanoscale multiple input/out optical logic gate with high-fidelity signal.
Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels
Authors: Lang Chao , LaNasa Jacob A. , Utomo Nyalaliska , Xu Yifan , Nelson Melissa J. , Song Woochul , Hickner Michael A. , Colby Ralph H. , Kumar Manish , Hickey Robert J. 
Published: August 2019

AbstractDue to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction into a B-block selective solvent. Although much of the focus in ABA triblock copolymer self-assembly has been on equilibrium nanostructures, little attention has been paid to the guiding principles of nanostructure formation during non-equilibrium processing conditions. Here we report a universal and quantitative method for fabricating and controlling ABA triblock copolymer hierarchical structures using solvent-non-solvent rapid-injection processing. Plasmonic nanocomposite hydrogels containing gold nanoparticles and hierarchically-ordered hydrogels exhibiting structural color can be assembled within one minute using this rapid-injection technique. Surprisingly, the rapid-injection hydrogels display superior mechanical properties compared with those of conventional ABA hydrogels. This work will allow for translation into technologically relevant areas such as drug delivery, tissue engineering, regenerative medicine, and soft robotics, in which structure and mechanical property precision are essential.
Hybrid genome assembly and annotation of Danionella translucida
Authors: Kadobianskyi Mykola , Schulze Lisanne , Schuelke Markus , Judkewitz Benjamin 
Published: August 2019

AbstractStudying neuronal circuits at cellular resolution is very challenging in vertebrates due to the size and optical turbidity of their brains. Danionella translucida, a close relative of zebrafish, was recently introduced as a model organism for investigating neural network interactions in adult individuals. Danionella remains transparent throughout its life, has the smallest known vertebrate brain and possesses a rich repertoire of complex behaviours. Here we sequenced, assembled and annotated the Danionella translucida genome employing a hybrid Illumina/Nanopore read library as well as RNA-seq of embryonic, larval and adult mRNA. We achieved high assembly continuity using low-coverage long-read data and annotated a large fraction of the transcriptome. This dataset will pave the way for molecular research and targeted genetic manipulation of this novel model organism.
Impact of pre-existing disorder on radiation defect dynamics in Si
Authors: Wallace J. B. , Bayu Aji L. B. , Shao L. , Kucheyev S. O. 
Published: August 2019

AbstractThe effect of pre-existing lattice defects on radiation defect dynamics in solids remains unexplored. Here, we use a pulsed beam method to measure the time constant of defect relaxation for 500 keV Ar ion bombardment of Si at 100 °C with the following two representative types of pre- existing lattice disorder: (i) point defect clusters and (ii) so-called “clamshell” defects consisting of a high density of dislocations. Results show that point defect clusters slow down defect relaxation processes, while regions with dislocations exhibit faster defect interaction dynamics. These experimental observations demonstrate that the dynamic aspects of damage buildup, attributed to defect trapping-detrapping processes, can be controlled by defect engineering.
Surface Enhanced Raman Spectroscopy for Single Molecule Protein Detection
Authors: Almehmadi Lamyaa M. , Curley Stephanie M. , Tokranova Natalya A. , Tenenbaum Scott A. , Lednev Igor K. 
Published: August 2019

AbstractA two-step process of protein detection at a single molecule level using SERS was developed as a proof-of-concept platform for medical diagnostics. First, a protein molecule was bound to a linker in the bulk solution and then this adduct was chemically reacted with the SERS substrate. Traut’s Reagent (TR) was used to thiolate Bovine serum albumin (BSA) in solution followed by chemical cross linking to a gold surface through a sulfhydryl group. A Glycine-TR adduct was used as a control sample to identify the protein contribution to the SER spectra. Gold SERS substrates were manufactured by electrochemical deposition. Solutions at an ultralow concentration were used for attaching the TR adducts to the SERS substrate. Samples showed the typical behavior of a single molecule SERS including spectral fluctuations, blinking and Raman signal being generated from only selected points on the substrate. The fluctuating SER spectra were examined using Principle Component Analysis. This unsupervised statistics allowed for the selecting of spectral contribution from protein moiety indicating that the method was capable of detecting a single protein molecule. Thus we have demonstrated, that the developed two-step methodology has the potential as a new platform for medical diagnostics.
Rice bran extract supplement improves sleep efficiency and sleep onset in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study
Authors: Um Min Young , Yang Hyejin , Han Jin Kyu , Kim Jin Young , Kang Seung Wan , Yoon Minseok , Kwon Sangoh , Cho Suengmok 
Published: August 2019

AbstractWe previously reported that rice bran extract supplement (RBS) administration to mice decreased sleep latency and induced non-rapid eye movement (NREM) sleep via inhibition of the histamine H1 receptor. Based on this, we performed the first clinical trial to investigate whether RBS would be beneficial to subjects with disturbed sleep. We performed a randomized, double‐blinded, placebo‐controlled, 2-week study. Fifty subjects with sleep disturbance were enrolled and received either RBS (1,000 mg/day) or placebo. Polysomnography was performed, and Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale (ESS), and Fatigue Severity Scale were administered at the initiation and termination of the study. Compared with the placebo, RBS led to significant polysomnographic changes, including decreased sleep latency (adjusted, P = 0.047), increased total sleep time (P = 0.019), and improved sleep efficiency (P = 0.010). Additionally, the amount of stage 2 sleep significantly increased in the RBS group. When adjusted for caffeine intake, wakefulness after sleep onset, total wake time, and delta activity tended to decrease in the RBS group. RBS administration decreased ESS scores. There were no reported serious adverse events in both groups. RBS improved sleep in adults with sleep disturbance. Trial registration: WHO ICTRP, KCT0001893.
Single-Cell Quantification of mRNA Expression in The Human Brain
Authors: Jolly Sarah , Lang Verena , Koelzer Viktor Hendrik , Sala Frigerio Carlo , Magno Lorenza , Salinas Patricia C. , Whiting Paul , Palomer Ernest 
Published: August 2019

AbstractRNA analysis at the cellular resolution in the human brain is challenging. Here, we describe an optimised approach for detecting single RNA transcripts in a cell-type specific manner in frozen human brain tissue using multiplexed fluorescent RNAscope probes. We developed a new robust analytical approach for RNAscope quantification. Our method shows that low RNA integrity does not significantly affect RNAscope signal, recapitulates bulk RNA analysis and provides spatial context to transcriptomic analysis of human post-mortem brain at single-cell resolution. In summary, our optimised method allows the usage of frozen human samples from brain banks to perform quantitative RNAscope analysis.
Magnetic properties of six-legged spin-1 nanotube in presence of a longitudinal applied field
Authors: ElMaddahi Zakaria , El Hafidi Moulay Youssef , El Hafidi Mohamed 
Published: August 2019

AbstractIn this paper, we investigate the magnetic behavior of a single-walled hexagonal spin-1 Ising nanotube by using the effective field theory (EFT) with correlations and the differential operator technique (DOT). The system consists of six long legs distributed parallel to each other on a hexagonal basis. Within each chain, spin sites are regularly positioned and magnetically coupled through a J// exchange interaction along the chains and J⊥ between adjacent chains. Key equations of magnetization, susceptibility and critical temperatures are established, numerically resolved and carefully analyzed for some selected exchange couplings and various applied magnetic fields. In addition to the phase diagram, interesting phenomena are noted, particularly for opposite exchange interactions where magnetization plateaus and frustration are discovered.
Enhanced dechlorination and biodegradation of 2-chloroaniline by a 2-aminoanthraquinone-graphene oxide composite under anaerobic conditions
Authors: Lu Hong , Zhang Tiantian , Zhou Yang , Zhou Jiti , Wang Jing , Wang Xiaolei 
Published: August 2019

AbstractThe effect of a 2-aminoanthraquinone-graphene oxide (AQ-GO) composite on the anaerobic dechlorination and degradation of chloroanilines by an enriched bacterial consortium was investigated. The results showed that the maximal degradation efficiency of 20 mg/L 2-chloroaniline (2-CA) reached 91.4% at a dose of 20 mg/L AQ-GO in 30 d. Moreover, the pseudo-first-order rate constant of 2-CA degradation in the AQ-GO-mediated system was 2.9-fold higher than those in AQ- and GO-mediated systems alone. During this process, a synergetic effect between AQ and GO was observed, which was attributed to the increased intracellular and extracellular electron transfer pathways. GC-MS analysis showed that 2-CA could be degraded to hexanoic acid and ultimately mineralized to CO2. Illumina MiSeq sequencing revealed that additional AQ-GO significantly increased the relative abundance of Firmicutes. Further analysis showed that the populations of the genera Oscillospira, unclassified Lactobacillales, unclassified Veillonellaceae and Ruminococcus exhibited positive correlations with the rate constant of 2-CA degradation and the dehydrogenase activity of bacterial consortium. These findings indicated that AQ-GO promoted the enrichment of functional bacteria and increased the bacterial activity, resulting in the enhanced dechlorination and degradation of 2-chloroaniline.
Ensemble age inversions for large spectroscopic surveys
Authors: Mints Alexey , Hekker Saskia , Minchev Ivan 
Published: August 2019

Context. Galactic astrophysics is now in the process of building a multi-dimensional map of the Galaxy. For such a map, stellar ages are an essential ingredient. Ages are measured only indirectly however, by comparing observational data with models. It is often difficult to provide a single age value for a given star, as several non-overlapping solutions are possible.
Aims. We aim at recovering the underlying log(age) distribution from the measured log(age) probability density function for an arbitrary set of stars.
Methods. We build an age inversion method, namely we represent the measured log(age) probability density function as a weighted sum of probability density functions of mono-age populations. Weights in that sum give the underlying log(age) distribution. Mono-age populations are simulated so that the distribution of stars on the log g-[Fe/H] plane is close to that of the observed sample.
Results. We tested the age inversion method on simulated data, demonstrating that it is capable of properly recovering the true log(age) distribution for a large (N > 103) sample of stars. The method was further applied to large public spectroscopic surveys. For RAVE-on, LAMOST and APOGEE we also applied age inversion to mono-metallicity samples, successfully recovering age–metallicity trends present in higher-precision APOGEE data and chemical evolution models.
Conclusions. We conclude that applying an age inversion method as presented in this work is necessary to recover the underlying age distribution of a large (N > 103) set of stars. These age distributions can be used to explore age–metallicity relations, for instance.
A Missing Link: Thinking | making | presenting
Authors: Karimi Zamila , Uddin M Saleh 
Published: August 2019

Let whoever may have attained to so much as to have the power of drawing know that he holds a great treasure ... Michelangelo
The tradition of architectural drawings and making as a means of design thinking in a constant feedback loop results in discoveries that facilitate creative thinking in an iterative process. In the digital age, notion of drawing and making by hand as a cognitive process of thinking is fading. This trend is increasingly evident in upper-level architecture students who depend strictly on digital tools for design thinking, missing many critical decisionmaking steps. Concepts of scale, diagramming, composition, materiality are missing − part of the challenge is the computer screen and the lack of tactical autonomy with physical materials − pen, pencil, brush, architectural scale, materiality, construction, assemblage. How can we as educators assert that drawings are not just architectural representations, but a means to architectural inquiry? Why is it critical for our students to use hand drawings, sketching and diagramming when exploring ideas? Can small gestural models provide notions of scale, materiality, and construction? Teaching pedagogy has always engaged new modes of design thinking and communications as a way of design inquiry − a trait essential to architects. Historically, since the Renaissance, drawings have been the catalyst to advance architectural discourse. In the 20th century, different movements such as De Stijl, Constructivism and Bauhaus used a multi-disciplinary approach combining art and technology through the lens of drawing and making that led to a new wave of design pedagogy to push their imaginations into new territories which the digital augmented as technology advanced. We believe that today’s students need to continue to develop both hand and digital skills in tandem to optimize design thinking, making and presentation techniques. In doing so, they can advance architectural pedagogy to new heights as those before did; critically in a material and physical sense: as an embodied spatial experience.
Aneurysma-Clipping
Authors: Gramlich Simone , Wittmann Nadja 
Published: August 2019

ZusammenfassungAneurysmen können durch minimalinvasive Verfahren (wie zum Beispiel dem Coilling)
versorgt werden oder offen, mikrochirurgisch durch das Clipping. Diese Operation
erfordert ein gut eingespieltes Team, das während des kompletten Eingriffs
hochkonzentriert arbeiten muss, um im Falle einer Ruptur schnell handeln zu
können und damit ein gutes Outcome für den Patienten sicherzustellen.
Resultados de sobrevida no médio prazo da haste femoral não cimentada Logical
Authors: Diesel Cristiano Valter , Ribeiro Tiango Aguiar , Macedo Carlos Alberto de Souza , Galia Carlos Roberto 
Published: August 2019

Resumo
Objetivo Avaliar os resultados clínicos e radiográficos da haste femoral não cimentada Logical (Baumer, Mogi Mirim, SP, Brasil) nas artroplastias totais do quadril (ATQs).
Método Foi realizada uma coorte retrospectiva de 632 pacientes submetidos à artroplastia primária do quadril por coxartrose nos quais foram implantadas hastes femorais não cimentadas Logical. Todos os pacientes eram provenientes do ambulatório de Cirurgia do Quadril da instituição. O período do estudo compreendeu de janeiro de 2004 a janeiro de 2015. O desfecho definido para avaliar a sobrevida da haste foi a indicação clínica e radiográfica da revisão ou a revisão propriamente dita da haste femoral por qualquer causa.
Resultado Observaram-se curvas de sobrevida estimadas > 95%, com um seguimento variando de 2 até 13 anos. Houve baixa incidência de fraturas periprotéticas transoperatórias (0,02%). Não foi observada migração axial ou atrofia óssea cortical na amostra radiográfica avaliada.
Conclusão Os resultados demonstram, no médio prazo, excelente sobrevida da haste femoral não cimentada Logical. Embora ainda sejam aguardados estudos no longo prazo, este implante parece ser seguro e promissor para ser utilizado nas artroplastias primárias do quadril.
First Sternal Cleft Repair Using a Porous Alumina Ceramic Prosthesis in a 9-Year-Old Child
Authors: Fouilloux Virginie , Bertin François , Peltier Emilie , Jouve Jean-Luc 
Published: August 2019

AbstractSternal cleft is a rare congenital abnormality, often associated with other congenital defects. We present the case of a 9-year-old child with complete sternal cleft, treated with an innovative sternal prosthesis. Surgery was performed to protect the heart and also, as pulsations was visible, leading to serious esthetical concerns, to enhance school integration, which was difficult. The porous alumina device used was initially designed for sternal reconstruction after refractory deep sternal wound infection or carcinoma. Surgery and early follow-up were simple. There was no complication and the follow-up of more than 1 year reveals a good healing without breath discomfort and a correct development of the chest wall. In this rare indication, the alumina ceramic sternal prosthesis offers a reliable alternative to classical methods, such as muscle flap, autogenous tissue transfer, costal homograft, and other prosthetic materials like mesh or synthetic patch.
Fatores preditivos de morte após cirurgia para tratamento de fratura proximal do fêmur
Authors: Antunes Filho Jurandir , Silva Armando D'Lucca de Castro e , Mendes Junior Adriano Fernando , Pereira Felipe Jader Coelho , Oppe Igor Gerdi , Loures Elmano de Araújo 
Published: August 2019

Resumo
Objetivo Avaliar fatores preditivos de morte em pacientes de idade igual ou superior a 70 anos com fratura proximal do fêmur submetidos a tratamento cirúrgico.
Métodos Análise de prontuários médicos criando-se uma coorte retrospectiva com seguimento de 6 meses. Foram analisados 124 prontuários após aplicação dos critérios de inclusão e exclusão. Todos os pacientes foram tratados por um único cirurgião ortopédico em condições de uniformidade.
Resultados Taxa de mortalidade de 34.7%, sendo o perfil mais comum de paciente o indivíduo do gênero feminino, com 85 anos e ao menos 1 comorbidade. Os pacientes com idade superior a 85 anos, internação hospitalar por mais de 7 dias, ao menos 1 comorbidade presente e internação em centro de terapia intensiva (CTI) apresentaram maior risco de óbito (respectivamente 2; 2,5; 4 e 4 vezes maior).
Conclusão Em relação ao desfecho óbito, apesar de não encontramos diferença estatisticamente significativa no que se refere à topografia da lesão e como essas se comportam no momento em que coexistem junto a internação em CTI, acreditamos na necessidade de maiores investigações sob essa ótica na população com o perfil estudado.
Avaliação comparativa das incidências radiográficas cross-table e Ducroquet para a medição do ângulo alfa do quadril
Authors: Polesello Giancarlo Cavalli , Queiroz Marcelo Cavalheiro , Junior Walter Ricioli , Rudelli Marco , Nunes Marcus Aurelius Araújo , Amaral Denise Tokechi 
Published: August 2019

Resumo
Objetivo O objetivo do presente trabalho é comparar a equivalência da medida do ângulo alfa do quadril usando as incidências laterais de Ducroquet e de cross-table.
Método Estudamos 90 pacientes, com um total de 95 quadris, e padronizamos a realização das radiografias conhecidas como “Ducroquet” e “cross-table.” A incidência de perfil de cross-table foi realizada em 15° de rotação interna com o paciente em posição supina, e a incidência de perfil de Ducroquet foi padronizada com o paciente posicionado em decúbito dorsal, em 90° de flexão e 45° de abdução do quadril. O ângulo alfa foi medido em ambas as radiografias de perfil, por dois radiologistas especializados em afecções musculoesqueléticas. As medidas foram realizadas em 2 épocas diferentes: uma avaliação inicial e outra após 4 semanas. O teste t de Student foi utilizado e calculou o coeficiente de correlação intraclasse (CCI).
Resultados Encontramos boa correlação intraobservador para ambas as incidências radiográficas em diferentes momentos. Não houve diferença estatisticamente significante entre as medidas feitas pelas duas visualizações. No entanto, a correlação interobservadores foi baixa.
Conclusão A incidência radiográfica de perfil de Ducroquet é uma boa opção para a medida do ângulo alfa e pode ser usada ao invés da incidência radiográfica de perfil cross-table.