bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEIDEGGER’S HUMAN DIMENSION UNDERSTANDING OF TECHNOLOGY
Authors: Uliana R. Vynnyk  
Published: May 2019

The aim of the research is to identify M. Heidegger's human dimension approach to the issue of technology .It is achieved by means of applying methods of analysis and synthesis in relation to philosopher’s philosophical and technical ideas. Scientific novelty. Philosopher’s important human dimension trends concerning technology are outlined in the research and are manifested in the concern for individuals to keep their humanity and dignity and make for the freedom eliminating everything that may adversely affect their essence.(немного поменяла слова и их порядок) The term "individual measurability" involves a process of spiritual and intellectual development of a man and, in this context, through his development and humanity one should evaluate everything created by him; technical, social progress should be seen primarily from the point of view of a free man, humane, rationally and existentially independent from the artificially created world, who is able to play an advanced role in the process of his own development, social progress and technology. Techniques and technologies, in their turn, should progress, based primarily on human needs. Individuals, coexisting with technical means should take everything that is good for them and simultaneously use them for their spiritual and personal development. Conclusion. Having occupied a special position in relation to the tradition of European criticism, the philosopher considered technology, its essence and specificity, as well as features of technical activities in different historical periods to be a subject of a positive philosophical analysis. Heidegger broke with the tradition of European philosophy of technology, which focused its attention on the direct, "obvious" achievements of progress, having showed that the effects of intrusion of technology are diverse and difficult to be predicted in the long run. Technological dependence is hardly fatal to humans in the sense that it contains distinct preconceived thinking, behavior and consciousness.
Cranial Irradiation for Patients with Epidermal Growth Factor Receptor (EGFR) Mutant Lung Cancer Who Have Brain Metastases in the Era of a New Generation of EGFR Inhibitors
Authors: Lee Jih-Hsiang , Chen Hsuan-Yu , Hsu Feng-Ming , Chen Jin-Shing , Liao Wei-Yu , Shih Jin-Yuan , Yu Chong-Jen , Chen Kuan-Yu , Tsai Tzu-Hsiu , Yang James Chih-Hsin 
Published: May 2019

Abstract

Background
Immediate whole brain radiation (WBRT) has been the standard for patients with lung cancer with brain metastases. The study aims to evaluate the effect of immediate cranial irradiation in patients with epidermal growth factor receptor (EGFR) mutant lung cancer in the era of a new generation of EGFR inhibitors.

Materials and Methods
Medical records of 198 patients with EGFR mutant non-small cell lung cancer and brain metastases at initial metastatic diagnosis were reviewed. Patients were categorized into four groups: immediate WBRT, immediate cranial stereotactic radiosurgery (SRS), delayed radiation upon progression of cranial lesions (DRT), and never cranial irradiation (NRT). Overall survival (OS) and progression-free survival related to EGFR inhibitors were analyzed.

Results
The SRS group had the fewest brain metastases and fewest extracranial lesions, and the DRT and NRT groups had the smallest brain metastases. Median survival were 18.5, 55.7, 21.1, and 18.2 months for the WBRT, SRS, DRT, and NRT groups, respectively. Patients who had received EGFR T790M inhibitors survived longer (41.1 vs. 19.8 months). In multivariate analysis, the OS of patients in the SRS group was longer than that in the NRT group (adjusted hazard ratio [aHR]: 0.315). Patients who had fewer extracranial lesions and who had received EGFR T790M inhibitor treatments also survived longer (aHR: 0.442 and 0.357, respectively).

Conclusion
Immediate stereotactic radiosurgery but not whole brain radiation was associated with longer survival. Because of patient heterogeneity and the introduction of EGFR T790M inhibitors, the timing and modality of cranial irradiation should be determined individually, and cranial irradiation may be omitted for selected patients.

Implications for Practice
Immediate whole brain radiation has been the standard for patients with lung cancer with brain metastases. In this study, it was observed that, for patients with epidermal growth factor receptor (EGFR) mutant advanced lung cancer who had brain metastases, there was no difference in survival between patients who never received cranial irradiation and those who received whole brain radiation immediately. Patients who received immediate stereotactic radiosurgery or who had ever received EGFR T790M inhibitors survived longer. Patients who received immediate stereotactic radiosurgery have fewer brain metastases. These findings suggest that the timing and modality of cranial irradiation should be determined individually, and cranial irradiation may be omitted in selected patients.
TRATAMENTO DE DENTES COM RECESSÃO GENGIVAL E ABRASÃO CERVICAL
Authors: Andrade Lyla Prates de , Biscarde Adriana , Moreira Alexandre , Ribeiro Érica , Bittencourt Sandro 
Published: May 2019

Purpose: To review the literature and show a case treated by an integrated restorative and periodontal approach. Case description: A treatment of a Miller Class III gingival recession associated with cervical abrasion on his maxillary left canine, which was previously restored with resin composite and covered by a subepthelial connective tissue graft showed improvement of the hypersensitivity and esthetics with no signs of gingival inflammation. Conclusions: The Miller Class I and II gingival recession with cervical abrasion can be successfully treated associating the defect restoration with the root recover. However, it’s necessary more studies to support these positive results.
DESMISTIFICANDO O ATENDIMENTO ODONTOLÓGICO À GESTANTE: REVISÃO DE LITERATURA
Authors: Santos Bastos Reuja Diany , Santos Silva Bianca Dos , Cardoso Juliana Andrade , Farias Jener Gonçalves , Carneiro Spinola Falcão Gleicy Gabriela Vitória 
Published: May 2019

Pregnancy is a natural biological process in women’s lives. However, in this period, physiological changes occur in the body of the pregnant woman who also reflects on oral health. Studies reinforce the relationship between the health condition of the oral cavity and the body’s overall health, as well as their implications for the fetus. Thus highlights the importance of Dentistry in health care during pregnancy. However, dental care for pregnant women requires qualification for them to be selected the safest agents. It is necessary, therefore, the formation of dentists able to provide differentiated services for pregnant women, including preventive and curative actions for to promote oral health of the mother and, consequently, the baby. This article has for objective to revise available literature of the odontological treatment during the period of the pregnancy, demystifying dental care pregnant women, in order to make possible clarifications to base the clinical behaviors in scientific evidences.
PRODUTOS CLAREADORES OVER THE COUNTER: UMA REVISÃO DE LITERATURA
Authors: Caldas Adriele , Vasconcelos Diane , Sampaio Geovana , Campos Juliana , Aragão Lilibeth , Cavalcanti Andrea Nóbrega 
Published: May 2019

In order to the great aesthetic appeal for white teeth today, whitening has become very popular and affordable on the market. In the current days, there are many whitening products available in pharmacies, groceries and convenience stores. These products are called “over the counter” or OTC products. They are sold as cosmetics with non-prescription. The objective of this study is to review the literature articles surveyed in BVS, Scielo , Medline databases following the Descritores em Ciências da Saúde ( DeCS ) with emphasis on recent bleaching techniques introduced to the market as well as its indications, contraindications, advantages and disadvantages. OTC products do not have commercial regulation which hinders the supervision of tooth whitening by a dentist. These contain different concentrations of hydrogen peroxide or carbamide which can bring consequences such as tooth sensitivity and gum when used without indication and supervision.
A OSTEOPOROSE PODE AGRAVAR A DOENÇA PERIODONTAL?: UMA REVISÃO DE LITERATURA
Authors: Naves Roberta Catapano , Bulhões Tainá , Costa Leonardo , Barbosa Monica Dourado , Almeida Susyane 
Published: May 2019

With the population aging, the chronic diseases related to the seniors, as the osteoporosis, increased generating a problem of public health that affects the quality of life of the population directly. The osteoporosis is a systemic disease that causes the mineral unbalance of the bones causing bone fragility and increase in the probability of fractures. Besides the long bones, it can attack the alveolar processes of the jawbone and of the jaw, could worsen the disease periodontal and to take to the dental loss. The objective of this work is to approach, through a revision of the literature, the present knowledge about the possible influence of the osteoporosis in the periodontal disease and in the levels of the alveolar bone mineral density.
TRATAMENTO ENDODÔNTICO DE INCISIVO LATERAL SUPERIOR COM CURVATURA APICAL ACENTUADA E LESÃO PERIAPICAL: RELATO DE CASO
Authors: Souza Ronaldo Araújo , Gavazza Fernando , Da Costa Pinto Dantas João , Lago Maurício , Colombo Suely 
Published: May 2019

Complexity of root canal treatment is well recognized, however some specific situations are still more difficult, such as treatment of apical third with accentuated curvature. Nevertheless, recent techniques of instrumentation and obturation brought new persperctives and became a determinant factor for successful treatment. Through the treatment of a maxillary left lateral incisor, with accentuated apical curvature, pulpal necrosis and periapical lesion through manual instrumentation and lateral condensation technique of root canal filling, this article is aimed to discuss whether these recent techniques of instrumentation and obturation of root canal are actually determinant factors for the success in endodontic treatment.
BIFOSFONATOS ASSOCIADOS À OSTEONECROSE DOS MAXILARES: UMA ANÁLISE BIBLIOMÉTRICA
Authors: Fontenele Jimmy Willy Nogueira , Macedo Alexandro Sousa , Pedrosa Marlus da Silva , Vasconcelos Marcus Barreto , Lopes Maura Régia Lima Verde Moura 
Published: May 2019

Introdução: Com a popularidade aumentada da terapia com bisfofonatos, é provável que cirurgiões-dentistas se deparem com pacientes fazendo uso destes medicamentos, sendo imprescindivel ponderar os riscos das condições orais e sistêmicas que envolvem o uso de bifosfonatos. Para tal, uma avaliação da literatura é necessária para compreensão desta condição, favorecendo um melhor tratamento ao paciente. Objetivo: Mapear, através de uma análise bibliométrica na base de dados Web of Science, os recentes avanços na produção cientifica internacional acerca da associação entre osteonecrose dos maxilares e bisfofonatos. Metodologia: Realizou-se um estudo bibliométrico na base de dados Web of ScienceTM a partir de artigos publicados entre 2003 a 2017, utilizando os termos de busca Osteonecrosis of Jaw AND Bisphophonates. Não foram aplicados filtros de refinamento para áreas de conhecimento, países ou idiomas dos estudos. A análise bibliométrica foi conduzida utilizando o software HistCiteTM. Resultados e Discussão: Foram identificadas 1395 publicações na Principal Coleção da Web of ScienceTM. Esses artigos foram publicados em 426 revistas diferentes indexadas e foram escritas por 5303 autores de 541 instituições em 26 países. A relação entre os artigos mostra que a temática é abordada de forma ampla e diversificada, apontando para uma gama de possibilidades da etiologia, prevenção e tratamento desta condição. Conclusão: A análise descritiva revelou um interesse crescente em pesquisas sobre osteonecrose dos maxilares induzida por bisfofonatos, bem como potencial para o desenvolvimento da área e contribuições para melhorar o entendimento sobre a etiologia, prevenção e tratamento desta condição.
REPARAÇÃO EM RESINA COMPOSTA: REVISÃO SISTEMÁTICA
Authors: De Alencar Vilson Rocha Cortez Teles , Cavalcante Micael , Firmino Rodrigo , Santos Jackceane , De Lima João Paulo Martins 
Published: May 2019

Introdução: A substituição total de restaurações de resina composta é uma das técnicas mais utilizadas por cirurgiões dentistas quando estas restaurações apresentam alguma falha. Essa técnica amplia o preparo cavitário, removendo tecido dentário sadio, podendo gerar danos pulpares. A reparação de resina composta substitui parcialmente a restauração preservando estrutura dental e o substrato remanescente de resina composta. Objetivo: Realizar uma revisão sistemática por meio de estudos que descrevessem a eficácia clínica e laboratorial da reparação em restaurações de resina composta defeituosas. Método: Como base para a pesquisa, foram acessados os bancos de dados PubMed, Scopus, BVS e SciELO, os descritores selecionados através do DesC e MeSH foram, Resinas compostas, Desgaste de restauração dentária, Falha de restauração dentária, Reparação de restauração dentária. Resultados: Foram incluídos todos os artigos que abordassem sobre a técnica de reparação. Conclusão: Existem poucas evidências cientificas que mostrem o sucesso e vantagens desse método sobre a substituição total, porém os estudos analisados já apresentam bons resultados.
DILACERAÇÃO RADICULAR: ANÁLISE RADIOGRÁFICA EM PACIENTES COM FISSURA LABIAL E/OU PALATINA NÃO SINDRÔMICA
Authors: Guimarães Laís Bastos , Lopes Gabriela dos Santos , Bezerra Paula Santana , De Santana Vitória Rodrigues , Medrado Alena Peixoto , Reis Silvia Regina 
Published: May 2019

Fissuras labiais e/ou palatinas não sindrômicas (FL/PNS) representam a anomalia congênita mais comum em humanos. Entretanto, são poucos os estudos que analisam a curvatura e dilaceração em pacientes acometidos pela FL/PNS. O objetivo deste estudo foi avaliar a prevalência de dilaceração radicular em 400 indivíduos portadores de FL/PNS, assim como relacionar o grau de curvatura da raiz com os diferentes tipos de fissuras. Observou-se que raízes de pré-molares e molares apresentaram diferentes direções (p<0,001). Raízes retas e inclinadas para a face distal foram mais prevalentes (46,6% e 44,5% respectivamente). Existem diferenças quanto a localização da curvatura em relação ao 1/3 radicular (p<0,001). As fissuras labiais e as fissuras palatinas apresentaram maior frequência de dilaceração radicular. Não foi observado associação significativa do grau de curvatura radicular dos molares e pré-molares a um tipo específico de fissura. Esses resultados sugerem a realização de estudo caso-controle para que questões relativas às diferenças de angulação entre os portadores de FL/PNS e a população em geral, sejam respondidas.
AVALIAÇÃO DA PERDA ÓSSEA RADIOGRÁFICA EM ADOLESCENTES COM LEUCEMIA MIELOIDE CRÔNICA
Authors: Dos Santos Esthefania Cimadon , Barbosa Marcelo Alves , Semenoff Tereza Aparecida Delle Vedove , Santos Jefferson Freitas , Nobreza Antonio Marcos da Silva , Da Silva Júnior Aurélio Rosa 
Published: May 2019

Objetivo: Avaliar a perda óssea radiográfica em pacientes portadores de Leucemia Mieloide Crônica. Materiais e métodos: As radiografias panorâmicas foram coletadas no banco de dados de um Centro especializado em pacientes especiais. Assim, foram selecionados 290 pacientes. Destes, apenas 31 tinham radiografia panorâmica adequada. O restante tinham radiografias insatisfatórias ou ausência de radiografia. Para o grupo controle (GC), imagens radiográficas foram coletadas e pareadas a pacientes do mesmo sexo, idade e sem patologias sistêmicas. As radiografias foram analisadas em uma câmara escura usando um negatoscópio, uma lupa, e uma régua de plástico. O avaliador estava calibrado (?aapa = 0,87). Os dados foram separados em dois grupos: pacientes com Leucemia Mieloide Crônica e pacientes Controle. Foi considerado como caso de perda óssea aquele que apresentasse uma distância entre a junção amelo-cementária até a crista óssea nas proximais de um primeiro molar inferior >4mm. O teste estatístico selecionado foi o Qui Quadrado, com o nível de significância estatística de 5%. Resultados: Os resultados do trabalho demonstram que as mensurações <4mm foram a maioria, sendo 28 (90,3%) dos sítios no Grupo Controle e 25 (80,7%) dos sítios no Grupo Leucemia(p>0,05). Para as mensurações >4mm houve 3 (9,7%) dos sítios no Grupo Controle e 6 (19,3%) no Grupo Leucemia – p<0,05. A idade dos pacientes não demonstram diferenças estatísticas entre os grupos p>0,05. Conclusão: A Leucemia Mieloide Crônica não demonstrou influenciar a ocorrência de uma maior perda óssea em radiografias panorâmicas.
Gillespiе syndrome, caused by previously undescribed mutation in the gene <i>ITPR1<i>
Authors: Sharkova I. V. , Akimova I. A. , Khlebnikova O. V. , Dadali E. L. 
Published: May 2019

Gillespie syndrome is one of the rare monogenic syndromes characterized by a combination of congenital muscular hypotonia, delayed psychomotor and speech development, ataxia and hypoplasia of the iris. The cause of disease – homozygous, compound heterozygous and heterozygous mutations in the gene ITPR1.We described a case history of a child of 1 year and 8 months whose parents were complaining of severe delay in psychomotor and speech development, and a violation of the functions of the visual analyzer. Neurological and ophthalmologic examinations were performed according to a standard procedure. Search for mutations was carried out using high-performance exome sequencing on NextSeg 500 (Illumina, USA) with an average coverage of at least 70–100x.Clinical and genetic characteristics of the patient with Gillespie syndrome due to the newly identified heterozygous missense mutation are presented. Mutation 1865T˃S in the 18 exon of the ITPR1 gene was found during the new generation sequencing of the exome. In the future, these data can be used to predict the characteristics of clinical manifestations and the severity of Gillespie syndrome, when a similar nucleotide substitution will be found in other patients.
Analysis of diurnal variability of sperm donors’ semen parameters
Authors: Korneyev Igor A. , Zasseev Ruslan D. , Pashina Ol’ga B. , Mamedov Ali E. , Kondrashkin Pavel S. , Krylov Oleg A. 
Published: May 2019

Introduction. Diurnal variability of sperm parameters is controversial and should be considered during medical evaluation and solicitation of sperm donors.
Aim: to evaluate diurnal variability of sperm parameters of anonymous sperm donors in reproductive medicine center.
Materials and methods. Records of 1253 semen samples analysis of 39 sperm donors (mean age 27.1 ± 3.9 years) were retrospectively studied in reproductive medicine center in Saint Petersburg. Semen analysis was performed according to WHO 2010 recommendations. Diurnal variations of semen volume, sperm concentration, total sperm number, progressive motility and number of progressively motile sperm were analyzed.
Results. Mean ejaculate volume, sperm total number and number of progressively motile sperm were higher after 3 p.m. (t = 5.63, p < 0.0001; t = 3.66, p = 0.0003 and t = 1.76, p = 0.078, respectively), while sperm concentration and percent of progressively motile sperm was lower (t = 2.03, p = 0.043 and t = 4.63, p = 0.0003, respectively).The lowest and the highest mean sperm numbers were registered in time slots between 12 a.m.–1 p.m. and 4 p.m.–5 p.m., respectively.
Conclusions. The study suggests the diurnal variability of sperm donors’ semen parameters. We might recommend a potential sperm donor preservation to be performed after 3 p.m., preferentially within 4 p.m.–5 p.m. interval.
A questionnaire based evaluation of teaching methods in Pharmacology among second MBBS students in Shadan Institute of Medical Sciences Hyderabad, Telangana, India
Authors: Begum Naseem , Sathrasala Ramesh , Goru Bhawani , M. Manikanta , M. Sharanya 
Published: May 2019

Background: Pharmacology is one of the important subjects studied during second year MBBS. The general stigma among students regarding pharmacology is that it is a dry and boring subject. Hence lecturers need to reform their teaching methods in order to make pharmacology teaching interesting and a significant learning experience by the students.Methods: A questionnaire based evaluation of 146 second MBBS students about teaching methods in pharmacology was conducted at Shadan institute of medical sciences, Hyderabad. Questionnaire was prepared from previous studies and validated by experts. The questionnaire was given to the students to be solved in one hour.Results: The mean age of the students was 20 plus or minus 2 years. There were 73% females and 27% males. 85% of students felt that pharmacology is an interesting subject. 67.2% wanted more of group discussions. 50.4% did not want any student seminars. 53.9% felt there should be more of problem stimulated lectures in pharmacology. 92% were interested in computer assisted learning. 57.5% of students preferred learning from textbook and class lectures. 68.1% students preferred to study pharmacology for regular tests only, 92% students wanted Multiple Choice Questions (MCQ’s) to be discussed in class.Conclusions: There is a definite need for modification of undergraduate curriculum so as to make pharmacology learning more understandable by students. Novel methods of teaching like small group discussions, computer assisted learning, bed side teaching etc can be adopted to make pharmacology an interesting and useful subject among students.
Furosemide induced bullous pemphigoid: a case report
Authors: D. Venu , R. Vijendra 
Published: May 2019

Bullous pemphigoid is an acquired autoimmune disease characterized by subepidermal vesicles and bullae. The etiology is mostly idiopathic with the highest occurrence in elderly patients. However, it is now well-accepted that bp has been triggered by or associated with drug therapy. Over 50 agents have been implicated as a cause of Drug-induced bullous pemphigoid, including diuretics, ace inhibitors, and antibiotics. We present a case of Bullous pemphigoid in a 75 year old male probably induced by furosemide. A 75 year old male was admitted to the dermatology department of KIMS hospital, Bengaluru. Presented with multiple tense bullae and vesicles over both upper limbs, forearm and few collapsed bullae and vesicles over the extensor aspect of forearm. Patient had a past history of myocardial infarction and undergone coronary artery bypass grafting for the same and treated with multiple medications. Among the treatment given injection furosemide was the one of the drug, after which he developed lesions and also presented with fluid filled bullae. A diagnosis of bullous pemphigoid was made based on clinical history and was treated with prednisolone, halobetasol and antibiotics. The lesions improved significantly with the above management and patient recovered enough to be discharged from the hospital after 5 days. Severe and serious reactions such as bullous pemphigoid can be caused by used drugs like furosemide.