bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in calcium levels in the endometrium throughout pregnancy and the role of calcium on endometrial gene expression at the time of conceptus implantation in pigs
Authors: Choi Yohan , Jang Hwanhee , Seo Heewon , Yoo Inkyu , Han Jisoo , Kim Minjeong , Lee Soohyung , Ka Hakhyun 
Published: May 2019

AbstractCalcium plays an essential role in regulating many cellular functions, including proliferation, differentiation, and apoptosis. In spite of its importance in the establishment and maintenance of pregnancy, changes in calcium levels at the maternal–conceptus interface during pregnancy and its action on endometrial gene expression are not well understood. Thus, we examined changes in calcium levels in the endometrium during pregnancy, calcium deposition at the maternal–conceptus interface during pregnancy, and the role of calcium on the expression of endometrial genes related to conceptus implantation during early pregnancy in pigs. The amounts of endometrial calcium increased during mid‐ to late pregnancy, and calcium deposition was mainly localized to endometrial and chorionic epithelial cells at the maternal–conceptus interface during pregnancy and conceptus tissues during early pregnancy. The amounts of total recoverable calcium in uterine flushings were greater on Day 12 of pregnancy than Day 12 of the estrous cycle, and estrogen increased absorption of calcium ions by endometrial tissues. Increasing endometrial calcium levels by treatment with A23187, a calcium ionophore, decreased the expression of the estrogen‐responsive endometrial genes AKR1B1, ESR1, FGF7, IL1RAP, LPAR3, S100G, SPP1, and STC1 and increased the expression of genes related to prostaglandin synthesis and transport, namely PTGES, PTGS2, and SLCO5A1. These data suggest that calcium ions at the maternal–conceptus interface play a critical role in the establishment and maintenance of pregnancy in pigs by regulating the expression of endometrial genes involved in conceptus implantation, as well as the attachment of endometrial epithelial and conceptus trophectoderm/chorionic epithelial cells during pregnancy.
Truss layout design under nonprobabilistic reliability‐based topology optimization framework with interval uncertainties
Authors: Wang Lei , Liu Yisi , Yang Yaowen 
Published: May 2019

SummaryA nonprobabilistic reliability‐based topology optimization (NRBTO) method for truss structures with interval uncertainties (or unknown‐but‐bounded uncertainties) is proposed in this paper. The cross‐sectional areas of levers are defined as design variables, while the material properties and external loads are regard as interval parameters. A modified perturbation method is applied to calculate structural response bounds, which are the prerequisite to obtain structural reliability. A deviation distance between the current limit state plane and the objective limit state plane, of which the expression is explicit, is defined as the nonprobabilistic reliability index, which serves as a constraint function in the optimization model. Compared with the deterministic topology optimization problem, the proposed NRBTO formulation is still a single‐loop optimization problem, as the reliability index is explicit. The sensitivity results are obtained from an analytical approach as well as a direct difference method. Eventually, the NRBTO problem is solved by a sequential quadratic programming method. Two numerical examples are used to testify the validity and effectiveness of the proposed method. The results show significant effects of uncertainties to the topology configuration of truss structures.
Incidence, risk factors, and outcomes of warfarin‐associated major bleeding in Thai population
Authors: Priksri Watcharapong , Rattanavipanon Wipharak , Saejear Wiwat , Tanyasaensook Krittika , Phrommintikul Arintaya , Chulavatnatol Suvatna , Nathisuwan Surakit 
Published: May 2019

AbstractPurposeThis study aimed to describe incidence, risk factors, and outcomes of warfarin‐associated major bleeding (WAMB) in Thai patients.MethodA nested case‐control study was conducted in a cohort of adult patients receiving ≥6 months of warfarin therapy who were prospectively followed up at a tertiary care hospital in Thailand during January 2011 to December 2014. Logistic regression was used to identify risk factors associated with WAMB. The area under the receiver operating characteristic (AUROC) curve was used to assess the performance of the HAS‐BLED score to predict WAMB in patients with non‐valvular atrial fibrillation (NVAF).ResultsAmong 1604 patients (2972 patient‐year of follow‐up), there were 93 major bleeding that occurred in 76 patients. The incidence of WAMB was 3.13 events per 100 patient‐year. Time in therapeutic range (TTR) of <60% (RR: 3.62, 95% CI: 1.94‐6.73, P < 0.001), mechanical valve replacement at mitral position (RR 3.43, 95% CI: 1.92‐6.16, P < 0.001) cancer (RR: 2.84, 95% CI: 1.11‐7.29, P = 0.029), and age ≥ 65 years (RR: 2.37, 95% CI: 1.20‐4.67, P = 0.012) were independent risk factors for WAMB. There were 17 fatalities and 12 cases of disabilities from WAMB. Mean cost of WAMB was 45 341.54 THB/event. An exploratory analysis suggested that HASBLED score demonstrated an excellent discriminatory capacity to predict WAMB among NVAF patients (AUROC of 0.91, 95% CI: 0.85‐0.97, P < 0.001).ConclusionWAMB in Thai population is common and associated with high rate of morbidity and mortality. Improvement in anticoagulation control is clearly needed.
Pursuing parenthood with cystic fibrosis: Reproductive health and parenting concerns in individuals with cystic fibrosis
Authors: Hailey Claire E. , Tan J. Winfield , Dellon Elisabeth P. , Park Eliza M. 
Published: May 2019

AbstractBackgroundAs life expectancy for cystic fibrosis (CF) has increased in recent decades, more individuals with CF are becoming parents. The objectives of this study were to describe the parenting and reproductive health concerns of individuals with CF and to identify the psychosocial and educational needs related to parenthood with CF.MethodsTwenty adults with CF, including parents and non‐parents, participated in one‐on‐one, semi‐structured interviews about reproductive health and parenting. Questions pertained to reproductive health knowledge, psychosocial adaptation to CF related to fertility and parenthood, parenting concerns in the context of CF, and psychosocial care needs. We performed thematic content analysis on interview transcripts and descriptive statistical analysis on participant demographics and health variables.ResultsA majority of participants (ten women and ten men, of whom half were parents) described their health as “stable” and “good/fair”; median FEV
1 was 66% predicted (range, 30‐105). Participants shared a range of experiences related to reproductive health discussions with CF care providers and expressed concerns about pregnancy, infertility, and adoption. Parents and non‐parents expressed concerns about balancing roles as parent and patient, the impact of anticipated health decline and early mortality on children, and communication with children. Participants identified a need for earlier, improved education for potential parents and resources for parents with CF.ConclusionsIndividuals with CF may not receive sufficient CF‐related reproductive health education, and they have wide‐ranging concerns about the intersecting roles of patient and parent. Results from this study can provide guidance for CF care providers to improve their understanding and response to the needs of individuals and families affected by CF.
Patients and families experience with pharmacist care at cystic fibrosis foundation accredited clinics
Authors: Young David C. , Autry Elizabeth , Zobell Jeffery T. , Kormelink Lauren , Homa Karen , Sabadosa Kathryn A. , Kanga Jamshed , Anstead Michael , Kuhn Robert 
Published: May 2019

AbstractCystic fibrosis (CF) is a complex genetic, multiorgan disease. The CF Foundation (CFF) recommends a multidisciplinary team (physician, nurse, respiratory therapist, dietitian, physical therapist, social worker, mental health coordinator, clinic coordinator, and pharmacist) to work with patients and families. The objective of our study was to describe the impact of a pharmacist involved in the care of patients and families from their perspective. The CF Patient and Family Experience of Care (PFEC) is a voluntary, 50‐question telephonic or internet‐based survey designed to continuously collect information from patients and their families regarding their care experience. From August of 2017 through February of 2018, five questions were added to the internet survey to assess the impact of the pharmacist on the care experience. From the 666 respondents, 54% reported that a pharmacist was involved in their CF care. At two CF clinics designated as “full access” to a pharmacist, respondents reported a higher percentage of the CF–team discussed medications compared to those from three clinics designated as “limited access” to the pharmacist (95% vs 67%). Respondents in clinics with “full access” to a pharmacist were significantly more likely to get their medications refilled on time (78% vs 63%) and reported using fewer pharmacies to fill their medications. Pharmacist involvement in CF care may improve patient's access to medication and the ability to sustain use.
A digestive tract expressing α‐amylase influences the adult lifespan of Pteromalus puparum revealed through RNAi and rescue analyses
Authors: Wang Beibei , Yang Yi , Liu Mingming , Yang Lei , Stanley David W , Fang Qi , Ye Gongyin 
Published: May 2019

AbstractBACKGROUNDMidgut and salivary gland α‐amylases are digestive enzymes required for the development of insects and have been investigated in some insect species. However, α‐amylases in the endoparasitioid wasps have not been reported. Pteromalus puparum (Hymenoptera: Pteromalidae) is a dominant endoparasitioid wasp that parasitizes many butterfly species, including the Brassicaceae pest Pieris rapae (Lepidoptera: Pieridae). Here, we studied the characteristics and functions of three α‐amylases in P. puparum.RESULTSWe cloned three genes encoding α‐amylases in P. puparum, PpAmy1, PpAmy2 and PpAmy3. The full length of the PpAmy1 cDNA is 1872 bp, encoding 496 amino acids, the PpAmy2 cDNA is 1863 bp long, encoding 518 amino acids, and PpAmy3 cDNA consists of 1802 bp encoding 521 amino acids. PpAmys are highly similar in amino acid sequences, but they have separate tissue distributions. Phylogenetic results show that gene duplications may occur between PpAmy2 and PpAmy3. PpAmy1 and PpAmy3 are most highly expressed in the digestive tract and the venom apparatus, respectively, while PpAmy2 is broadly expressed in all tissues. We report that PpAmy1 acts in the digestive tract, where it influences lifespan as demonstrated using RNAi and α‐amylase rescue analyses, and there is no significant difference in longevity when PpAmy2 and PpAmy3 are knocked down.CONCLUSIONPpAmys probably have roles in carbohydrate metabolism of P. puparum and its host/parasitoid relationships. The characterization and functional study of PpAmys lays the foundation for the protection and utilization of parasitoid resources, and the biological control of agricultural pests. © 2019 Society of Chemical Industry
On the tip of the brain: Understanding when negative reputational events can have positive reputation spillovers, and for how long
Authors: Paruchuri Srikanth , Pollock Timothy G. , Kumar Naveen 
Published: May 2019

AbstractResearch SummaryThis study contributes to the reputation spillover literature by showing how a crisis caused by a firm's capability failure enhances the reputations of its rivals. We consider how the combination of rivals' characteristics that increase their associability with the focal firm and the extent to which the crisis is salient in the minds of stakeholders can lead to positive reputation spillovers, and we also explore how long the positive reputation spillover lasts. Using a natural experiment based on the Escherichia coli outbreak in Chipotle's Seattle restaurants, we find that the reputations of other restaurants in the Seattle region were enhanced when the E. coli breakout was more salient and thus cognitively available, but only for Mexican restaurants that were geographically proximal to a Chipotle.
Managerial SummaryIn this study we conducted a natural experiment based on Chipotle's 2015 E. coli breakout to explore how a firm's capability failure affects the reputation of its competitors. We found that failures due to firm practices that differentiate the firm from others in its industry result in positive reputation spillovers, but only for the firms that are the most similar, and only for as long as the failure is salient to stakeholders. Thus, the benefit to firms from a competitor's failure is only temporary, and will not be experienced equally.
August Wöhler – founder of fatigue strength research
Authors: Zenner Harald , Hinkelmann Karsten 
Published: May 2019

AbstractThe year 2014 marked the 100th anniversary of August Wöhler's death. On that occasion the authors wrote a book about his scientific work, his work on the safety of components and structures in the emerging industrial society, his life and his significance for the historical development in the field of fatigue strength of components and structures [1]. Those investigations were accomplished in cooperation with the DVM (German Association for Materials Research and Testing). As national and international events have shown [2], that book is of great interest. Therefore, an English version suggested itself, not least because of the 200th anniversary of Wöhler's birth in 2019.August Wöhler was an interesting and unique character, influenced by the 19th century Industrial Revolution, especially railway development. The spread of that new technology caused numerous problems. Fractures occurred on axles, wheels and rails at stresses below the component's static fracture strength. Through systematic tests, August Wöhler was able to prove that repeated stresses far below the static strength might lead to fractures. The present article gives a brief overview of Wöhler's life and achievements.
An improved multidimensional modal pushover analysis procedure for seismic evaluation of latticed arch‐type structures under lateral and vertical earthquakes
Authors: Qu Yang , Luo Yongfeng , Zhu Zhaochen , Huang Qinglong 
Published: May 2019

SummaryPushover methods for seismic assessment of buildings under multidimensional earthquakes have been studied and retrofitted. However, these current methods are not suitable when applied to widely adopted arch‐type structures characterized by strong geometrical nonlinearity and coupling effects. An improved multidimensional modal pushover procedure with two‐stage analyses is proposed for seismic evaluation of latticed arches. Taking overall multidimensional response into consideration, modal stiffness of the equivalent single‐degree‐of‐freedom system is derived, and its capacity curve is determined during the first‐stage analysis. To provide a deformation profile with algebraic signs of response retained, the second‐stage analysis is conducted using the pushover load pattern derived from modal displacement superposition. The objective of the improved procedure is to overcome the drawback of the conventional modal pushover method, which describes the capacity curve resorting to base shear and roof displacement, and that of quadratic combination rules which eliminate the sign reversals of response. To validate its serviceability, nodal displacements and element stresses, as well as the yielding members, of two typical latticed arches are calculated. Through comparative analysis, the results by the improved procedure exhibit good agreement with those by response history analysis. Additionally, this procedure demonstrates great superiority over the conventional method for its satisfying accuracy.
Compliance forces, domestic policy process, and international regulatory standards: Compliance with Basel III
Authors: Coban Mehmet Kerem 
Published: May 2019

AbstractThis article contributes to our understanding of how and why developing countries would comply with international banking regulatory standards, Basel standards. The article demonstrates the interplay between opportunity structures constituted by transnationalization of public policymaking and domestic institutional setting, and how forces of compliance resonate in the domestic politics of compliance. The empirical findings are based on Turkey's compliance with Basel standards. It relies on fieldwork that involves semi-structured qualitative interviews with senior regulators and bankers, which are complemented with analysis of secondary data. The article shows that a capable and willing regulator could capitalize on the top-down policymaking style which restricts the regulatee's access to international negotiations, and sets the terms at the domestic level. Direct access to international negotiations, resource asymmetry in favor of the regulator, and superior “negotiation knowledge” helped the regulator pacify a critical, skeptical regulatee, and drive the compliance process. The article also shows that the compliance process takes place at three stages: policy formulation at the international level, an “interpretation stage” in between the international and the domestic levels, and finally the domestic policy process.
Attending Night School: Leadership lessons at the Jack Reacher Academy
Authors: Bathurst Ralph , Chrystall Andrew 
Published: May 2019

AbstractNight School is the 21st novel by Lee Child featuring the action hero Jack Reacher. As the title suggests, the novel performs a didactic function via an organizational comedy. By invoking James Joyce's Ulysses and his use of double plots, we focus our attention on Reacher as a model leader who occupies a middle space between extremes. He rejects type-set mechanistic responses to problems and navigates around the confusion raised through information overload. Reacher's leadership is enacted on the ground and in the moment, taking each new encounter as an opportunity to learn. His style, marked by a healthy distrust of authority and documents, an ability to follow the spirit of the law and staying flexible are all characteristic of a man who is continually aware of his environment, and not side-tracked by metaphysical constructs. The novel's denouement presents an assessment of both Reacher's and our learning.
The petroleum industry in the Netherlands - its setting and possible future
Authors: Alblas L.D. 
Published: May 2019

AbstractThe setting and possible future of the petroleum industry in the Netherlands is briefly discussed. The result of a risk assessment shows, that the Dutch hydrocarbon province can be divided in low, medium, high and very high-risk areas for new capital investments. The assets of operators in the Netherlands have been evaluated on exploration, production, storage and pipeline potential, now and in the future. Despite the presence of potential new plays, exploration activities are expected to decrease in the near future. Despite the possible development of marginal fields, which will be not adding major reserves, the production reserves will decrease in the next 10–15 years and many fields will be abandoned. However storage, pipeline infrastructure and gas marketing are expected to increase in the future, mainly because of the liberalisation of the Dutch gas market.
The distribution of Pre-Westphalian source rocks in the North German Basin – Evidence from magnetotelluric and geochemical data
Authors: Hoffmann N. , Jödicke H. , Gerling P. 
Published: May 2019

AbstractFor the first time this project attempts to directly correlate magnetotelluric and geochemical data with the aim of creating a model on the regional distribution of potential pre-Westphalian source rocks deposited in marine environments in the North German basin.Analysis of the magnetotelluric data shows, that there is a deep good conductor at the north-eastern fringe of the North German basin around the islands of Rügen and Usedom and on the mainland north east of the Anklam Fault. Through integration with seismic data and the offshore well G14 the conductor can be correlated with the Cambro-Ordovician Scandinavian Alum shales. To the south an adjoining area approximately corresponding to the depo-centre of the Rotliegend basin lacks a deep good conductor. Therefore it can be assumed that a regional distribution of comparable source rocks is unlikely. Another excellent and important conductor starts to the south west of the Lower Elbe Line extending along the Dutch-German border into the North Sea, and into the Münsterland. Its place in the local stratigraphy has not been adequately established. It is most likely that this good conductor corresponds to the black shales of the Early Namurian and the Dinantian, which is the case in the boreholes Münsterland 1 and Pröttlin 1 for example. In this paper they are collectively called Rhenohercynian Alum shales. On the Dutch-German border a transition into the “Bowland Shale” facies or equivalents is to be expected. It cannot be ruled out that even stratigraphically older black shales, possibly from the Cambro-Ordovician could contribute to the high integrated conductivity of the deep good conductor.The evidence of highly conductive layers in the deep subsurface poses the question whether these layers could be potential source rocks for the gases in the north German gas fields. This question can be answered with a clear yes. Gas and isotope geochemical studies on gases from producing Rotliegend deposits have shown that Rhenohercynian Alum shales have been a significant source for these fields. This will be illustrated in detail using the gas fields from the production province “Ems Estuary” as an example.
Value Analysis: Capturing Total Cost of Ownership reduction opportunities in E&P projects
Authors: van der Schans E. , van Lijssel J.W.N. , van Steenderen P. 
Published: May 2019

AbstractValue Analysis is a powerful tool to increase the value of a capital investment project and to capture cost saving opportunities. It is a method conceived during WorldWar II and frequently used on infrastructure projects, especially in the USA.The Value Analysis process typically consists of a well prepared 3 to 5 day workshop with focus on generating ideas to improve the current engineering concept. Emphasis is on screening all proposals in order to identify the most promising ideas. The workshop results in a number of proposals to modify the existing engineering concept.Stork Engineers & Contractors have used the Value Analysis method on several projects as well as in proposals for Engineering, Procurement and Construction (EPC) projects in the Exploration and Production (EP) industry.Typical results of Value Analysis led to a decrease of Total Cost of Ownership by some 10 to 30%. A well facilitated Value Analysis workshop also leads to mutual trust and understanding between the parties involved.A key element in a Value Analysis is (re)definition of the proposed functionality of a project. This is done through challenging the existing technical concept by increasing this functionality or by meeting this functionality at a lower cost.