bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-Patients: Online Health Seeking Behaviour of Cancer Patients in South Western Nigeria
Authors: Salako O. , Okediji P. , Agaga L.A. , Bashir B.M. , Mutiu J. , Fatiregun O. , Olatunji T. , Joseph A. 
Published: September 2018

Background: Cancer has been reported to be one of the top three diseases that patients research on the Internet. This is because the Internet is an evolving hub of cancer information and social support for patients. With the increasing connectivity and over 92,000,000 Internet enabled devices in Nigeria, it is expected that mobile health will proliferate and this will change the way cancer patients gather health information and resources, propagating a new age of e-patients. An e-patient is a health consumer who uses the Internet as a health resource. With over 100,000 new cancer cases diagnosed yearly in Nigeria, low doctor to patient ratio, constrained consultation time and limited access to specialist care, the need to promote patients to become e-patients could efficiently empower them to become better-educated healthcare consumers. However, there is a paucity of data on how Nigerian cancer patients use the Internet. Aim: To measure the utilization rate and patient attitudes toward the Internet. Methods: This descriptive cross-sectional study was carried out among 281 cancer patients across the department of radiotherapy in three teaching hospitals in south-western Nigeria in March 2018, using a self-administered questionnaire. The analysis was done with SPSS version 20, and the level of significance was set at < 0.05. Results: The mean age for the 281 participants was 50.8±14.2 years; with the majority between 41 and 60 years (46.6%); and females (78.3%). About 67.6% owned a smartphone ( Table 1 ); and 32% possessed a personal laptop/desktop computer, or lived in households with people with smartphones (66.9%). Majority of the respondents had consistent access to the Internet (59.1%) ( Table 2 ). They also had an e-mail and social media account (52%) in order of decreasing frequency: Facebook, 52.7%; WhatsApp, 18.1%; and Instagram, 17.1% ( Fig. 1 ). At least 43.1% had searched for cancer information online with the purpose of understanding the disease better (41.6%) ( Fig. 2 ). About 45.2% of the respondents also indicated that they would be comfortable having an online medical consultation with their oncologist; however, they had not used any health/cancer app before (71.2%). Patients aged 41-60 years, married, with tertiary level of education, and monthly incomes ≤ N50,000 (∼$140) were more likely to search for cancer information online ( P < 0.05). About 56.9% of the respondents did not use the Internet for cancer information because they preferred getting information directly from doctors (43.2%), lacked the knowledge of Internet use (33.6%), and lacked access to Internet-enabled devices (20.8%). Conclusion: With more cancer patients being connected to the Internet and an increasing trend to be e-patients, there is a need to leverage technology to provide patient education, consultation, navigation and social support services.[Table: see text] [Table: see text][Figure: see text][Figure: see text]
MetaPink Program: Simplifying the Breast Cancer Journey for Patients With Advanced Stage Breast Cancer in Nigeria
Authors: Nwankwo E. 
Published: September 2018

Background and context: Breast cancer is the number one diagnosed cancer in Nigeria. 75% of these breast cancer diagnosis are at stage 3 and 4. This is due in part to lack of awareness of the signs and symptoms, inadequate screening and diagnostic facilities, insufficient policies and guidelines, and fear. Metastatic breast cancer patients do not have the time nor the strength to deal with the stress, delay, and confusion of trying to find adequate care. Run For a Cure Africa (RFCA) wishes to establish a program that helps navigate metastatic breast cancer patients in Lagos state, and surrounding states in Nigeria toward breast cancer care and resources. Aim: The MetaPink program empowers and educates patients with advanced stage breast cancer by providing them with timely and relevant information and resources on their disease and how they, the patient, can improve their quality of life and overall prognosis. Additionally, RFCA creates greater awareness of metastatic breast cancer in the community and the necessity for regular screenings. Strategy/Tactics: This project is being implemented by RFCA. RFCA is working work with the health care professionals (HCP) in the oncology and community health department at the Lagos University Teaching Hospital (LUTH) in addition to their organization mentors, The Rose Foundation in Houston, Texas. RFCA is also working with community associations, drama troupes, and groups to create sensitization in hard to access areas. Patients and participants of the MetaPink program have a support team, through the monthly support group, with whom they fellowship, ask advice, gain insight, and just off load any looming concerns. Program/Policy process: RFCA enrolls metastatic patients through our supported clinics, call ins, and our screening outreaches. Each patient enrolled in the program gets a starter pack. RFCA hosts monthly support groups and Q&A sessions anchored by medical professionals, RFCA also hosts community outreach events via the radio, market drama skits, and musical awareness presentations. Periodically we follow-up and communicate with MetaPink program participants via MetaPink WhatsApp, telephone, in-person meetings/visits, and support group meetings. Outcomes: The objective of the MetaPink program is to simplify the breast cancer journey for metastatic breast cancer patients in Nigeria and give them the emotional support and confidence to understand and navigate through their personal breast cancer journey. RFCA also creates larger community awareness of advanced stage breast cancer in a method that is culturally appealing and resonates with the environment. What was learned: As the program progresses, RFCA will learn how to effectively navigate patients in this resource-poor environment. This will contribute to their quality of life and improved breast cancer management in Nigeria. [Figure: see text]
Road Map to Setting Up a Palliative Care Service in a Tertiary Center Gynecologic Oncology Unit in Egypt
Authors: Abdelbadee A. , Abou-Taleb H. , Abbas A. , Ali S. , Fakie N. , Adams T. , Gwyther L. , Krause R. 
Published: September 2018

Background and context: Developing countries struggle with high cancer mortality and low resources. Cancer patients experience pain and physical symptoms in addition to psychological, social and spiritual worries that increase as the patients' conditions progress. Palliative care (PC) primary goal is to help people live as well as they can for the duration of their illness, with the finest physical and emotional well-being possible despite complex problems. However, there are considerable barriers to PC service implementation in developing countries. Aim: Our goal is to set up a PC service and integrate it as a standard of care for gynecologic cancer patients managed at Assiut University Hospitals, Egypt. The objective of this study is to investigate the tools needed to integrate a PC service in any oncology service in developing countries. Strategy/Tactics: A capacity building and local provision PC development framework was laid. Strategies included expanding the gynecologic oncology unit, assessment of PC knowledge among health providers and medical students, assembling a multidisciplinary PC team, overseas PC training, establishing international links, providing essential medicine and addressing PC education. Program/Policy process: The gynecologic oncology unit capacity was expanded to accommodate long term admissions. PC knowledge among physicians, clinical nurse practitioners (CNPs) and medical students in Assiut University Hospitals was assessed using the modified Palliative Care Knowledge Test (PCKT). A multidisciplinary team that will deliver the PC service to our gynecologic cancer patients was assembled based on motivation and individual expertise in the aspects of PC from relevant departments as clinical oncology, surgery, pain and anesthesiology, psychiatry, physical therapy and rehabilitation and nutrition. The hospital leadership worked with the pharmacists to increase opioids quota and facilitate dispensing measures. The PC team leader engaged in a certified online PC course and arranged overseas training with the reputable Palliative Medicine Division at University of Cape Town well known for its legacy in delivering PC education. Outcomes: Ninety two physicians, 14 CNPs and 116 medical students completed the PCKT. The PCKT was composed of 20 questions and each correct answer was given 1 point. The overall total correct score was 7.41 ± 2.48 (Fig 1). Poor knowledge about PC was a strong indicator to acknowledge the gap in PC postgraduate training and undergraduate education. What was learned: Integration of a PC service for cancer patients in Egypt is feasible in spite of local resources constraints. A PC multidisciplinary team can be assembled from skilled specialists. Modifications of undergraduate and postgraduate curricula to include PC is crucial. Our model can be transferred to other low resource settings. [Figure: see text]
Practice Transformation: Early Impact of the Oncology Care Model on Hospital Admissions
Authors: Mendenhall Molly A. , Dyehouse Karyn , Hayes Jad , Manzo Joanie , Meyer-Smith Teresa , Guinigundo Andrew , Bourbeau Brian , Waterhouse David 
Published: September 2018

Purpose: The purpose of the Oncology Care Model (OCM) is to improve quality and reduce cost through practice transformation. A foundational tenant is to reduce avoidable emergency room (ER) visits and hospitalizations. In anticipation of being an OCM participant, we instituted a multidimensional campaign designed to meet these objectives. Methods: Prior actions included establishment of phone triage unit, after-hours and weekend calls, and institution of weekend urgent care. Results: On the basis of data from the Chronic Condition Warehouse, as provided by the Centers for Medicare and Medicaid Services, we were successful at reducing the acute care admissions rate by 16%. During the baseline period extending from Jan 2016-Mar 2016, the hospital admission rate was 27 per patient, per quarter, at an average cost per admission event of $11,122, translating to an inpatient cost per patient, per quarter, of $3,003. In the year one reporting period of July 2016-July 2017, the hospital admission rate declined to 22.6 per patient, per quarter, at an average cost per admission event of $11,106, translating to an inpatient cost per patient, per quarter, of $2,505. OCM patient survey scores improved. In addition, at Oncology Hematology Care, we achieved improved results compared with the risk-adjusted national averages for the following measures: readmissions (4.9 v 5.6 per 100 patients, respectively), ER use (17 v 18.6 per 100 patients, respectively), and observation stays (2.7 v 3.6 per 100 patients, respectively). Conclusion: By implementing a cost-efficient, reproducible, and scalable campaign targeting ER avoidance and hospitalizations, we were able to decrease hospital admissions. Reported Medicare savings amounted to nearly $798,000 in inpatient cost per quarter over 1,600 patients.
One Step Forward, Two Steps Back: Trends in Aggressive Inpatient Care at the End of Life for Patients With Stage IV Lung Cancer
Authors: Mrad Chebli , Abougergi Marwan S. , Daly Bobby 
Published: September 2018

Background: Patients with metastatic lung cancer are treated with palliative intent. Aggressive care at the end of life is a marker of poor-quality care. National trends and factors related to aggressive inpatient care at the end of life for these patients have not been evaluated. Methods: Patients with stage IV lung cancer and a terminal hospitalization were identified in the National Inpatient Sample database between 1998 and 2014. Longitudinal analysis was conducted to determine trends in aggressive inpatient care at the end of life and multivariate logistic regression was performed to determine associations with patient and hospital characteristics. Results: A total of 412,946 patients met the inclusion criteria. From 1998 to 2014, the proportion of patients admitted to the intensive care unit (ICU) during the terminal hospitalization increased from 13.3% to 27.9% ( P < .001). The ICU stay translated into a higher mean total cost of care (+$18,461; 95% CI, $17,460 to $19,463). Promisingly, palliative care encounters for terminal hospitalizations also increased during this period from 8.7% to 53.0% ( P < .01) and were correlated with a decrease in aggressive care at the end of life. However, this did not offset the trend in increased ICU use; mean total costs for a terminal hospitalization increased from $14,000 to $19,500, adjusted for inflation. A multivariable model demonstrates variation by patient and hospital characteristics in aggressive care use. Conclusions: Among patients with metastatic lung cancer there has been a substantial increase in ICU use during terminal hospitalizations, resulting in high cost for the health care system.
Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells
Authors: Lees Jarmon G. , Gardner David K. , Harvey Alexandra J. 
Published: September 2018

ABSTRACT
As human pluripotent stem cells (hPSCs) exit pluripotency, they reportedly switch from glycolytic energy production to primarily mitochondrial metabolism. Here, we show that upon ectoderm differentiation to neural precursor cells (NPCs), hPSCs increase glycolytic rate, ultimately producing more carbon as lactate than is consumed as glucose. However, glucose, lactate and pyruvate utilization decrease to half their PSC levels by the NPC stage, establishing a more quiescent metabolic state. Furthermore, we characterize a metabolic exit event within the first 24 h of differentiation, plausibly necessary to transition hPSCs out of the pluripotent state. Contrary to current thinking, mitochondrial mass does not increase during NPC induction. Instead, mitochondrial DNA copies and mitochondrial activity decrease, suggesting that mitochondrial metabolism either requires suppression, or is not required, for nascent ectoderm differentiation. Our work, therefore, contrasts with the dogma that the hPSC state is primarily glycolytic, transitioning to an oxidative metabolism upon the loss of the pluripotent state. Instead, we show that heightened glycolytic metabolism is acquired, indicating that metabolic modulation of both glycolysis and mitochondrial metabolism occurs during exit from pluripotency in hPSCs.
Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation
Authors: Le Magnen Clémentine , Virk Renu K. , Dutta Aditya , Kim Jaime Yeji , Panja Sukanya , Lopez-Bujanda Zoila A. , Califano Andrea , Drake Charles G. , Mitrofanova Antonina , Abate-Shen Cory 
Published: September 2018

ABSTRACT
Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative analysis of expression profiling data from human prostate tumors, we demonstrate a reciprocal relationship between inflammation and the status of the NKX3.1 homeobox gene associated with prostate cancer initiation. We find that cancer initiation in aged Nkx3.1 mutant mice correlates with enrichment of specific immune populations and increased expression of immunoregulatory genes. Furthermore, expression of these immunoregulatory genes is similarly increased in human prostate tumors having low levels of NKX3.1 expression. We further show that induction of prostatitis in Nkx3.1 mutant mice accelerates prostate cancer initiation, which is coincident with aberrant cellular plasticity and differentiation. Correspondingly, human prostate tumors having low levels of NKX3.1 have de-regulated expression of genes associated with these cellular processes. We propose that loss of function of NKX3.1 accelerates inflammation-driven prostate cancer initiation potentially via aberrant cellular plasticity and impairment of cellular differentiation.
This article has an associated First Person interview with the first author of the paper.
Naphthalimide-Based Fluorescent Dyes: Impact of Extension of π-Conjugation and Introduction of an Electron-Donating Moiety on the Photophysical Properties
Authors: Otsuki Joe , Yamano Minori , Yamano Tae , Sugawa Kosuke 
Published: September 2018

Abstract
Concerning a series of naphthalimide-based fluorescence dyes in which the π-system is extended with oligothiophene units, it has been revealed that the absorption and fluorescence maxima can be tuned over ca. 100 nm and ca. 180 nm range by extending π-conjugation, respectively. The effects of the solvent on the fluorescence quantum yield depend on the conjugation length. For the same series but with an electron-donating moiety (push-pull type dyes), the absorption and fluorescence maxima are less dependent on the conjugation length. The fluorescence quantum yields of the push-pull type dyes are large in toluene (&gt;0.3) but extremely low in DMSO. These results will be a guide for the design of naphthalimide-based sensors and probes.
gganatogram: An R package for modular visualisation of anatograms and tissues based on ggplot2
Authors: Maag Jesper L.V. 
Published: September 2018

Displaying data onto anatomical structures is a convenient technique to quickly observe tissue related information. However, drawing tissues is a complex task that requires both expertise in anatomy and the arts. While web based applications exist for displaying gene expression on anatograms, other non-genetic disciplines lack similar tools. Moreover, web based tools often lack the modularity associated with packages in programming languages, such as R. Here I present gganatogram, an R package used to plot modular species anatograms based on a combination of the graphical grammar of ggplot2 and the publicly available anatograms from the Expression Atlas. This combination allows for quick and easy, modular, and reproducible generation of anatograms. Using only one command and a data frame with tissue name, group, colour, and value, this tool enables the user to visualise specific human and mouse tissues with desired colours, grouped by a variable, or displaying a desired value, such as gene-expression, pharmacokinetics, or bacterial load across selected tissues. I hope that this tool will be useful by the wider community in biological sciences. Community members are welcome to submit additional anatograms, which can be incorporated into the package.A stable version gganatogram has been deposited toneuroconductor, and a development version can be found ongithub/jespermaag/gganatogram.
Protein Kinase R Is Constitutively Expressed in the Human Pancreas
Authors: Jonsson Alexander , Yngve Erik , Karlsson Marie , Ingvast Sofie , Skog Oskar , Korsgren Olle 
Published: September 2018

Summary Viral infection of the insulin-producing cells in the pancreas has been proposed in the etiology of type 1 diabetes. Protein kinase R (PKR) is a cytoplasmic protein activated through phosphorylation in response to cellular stress and particularly viral infection. As PKR expression in pancreatic beta-cells has been interpreted as a viral footprint, this cross-sectional study aimed at characterizing the PKR expression in non-diabetic human pancreases. PKR expression was evaluated in pancreas tissue from 16 non-diabetic organ donors, using immunohistochemistry, qPCR, and western blot. Immunohistochemistry and western blot showed readily detectable PKR expression in the pancreatic parenchyma. The qPCR detected PKR mRNA in both endocrine and exocrine samples, with a slightly higher expression in the islets. In conclusion, PKR is constitutively expressed in both endocrine and exocrine parts of the pancreas and its expression should not be interpreted as a viral footprint in pancreatic beta cells.
Reimagining lace: A contemporary response to place and textile making
Authors: Heffer Cecilia 
Published: September 2018

Abstract
Over the last decade interdisciplinary engagement with lace as a contemporary design source has opened up a new emerging space for designers to explore unconventional approaches to traditional technologies and materials. This can be evidenced through International Contemporary Lace exhibitions over recent years, whereby artists outside the discipline of textiles have been invited to explore material innovation as a means to open up new definitions of lace (Radical Lace USA, 2007; Lost in Lace UK, 2011; Love Lace Australia, 2011–13). This portrait is an overview of my own contemporary lace practice during this time. I view my work as a practice of a practice made up of iterations of the one intent – that is to explore notions of making as an embodied response to the materials and places that I work and live in. Traditionally lace could be read as a place marker and came to represent the family and region where they were made through the materials and patterns employed to make them. Drawn to the technical complexity that this allusive textile holds I am interested in demonstrating how making knowledges move between generations. Historically embroidered laces for example are known as ‘punto en aire’ (‘stitches in the air’). This prompts me to question how new notions of stitches in the air can be re-imagined as a modern-day place marker. The motivation behind my lace works is to create original work that reflect back a unique recognition of place. It is in the experience of recognition itself that enables us to view our environment in a new light.
Exhibition Reviews
Authors: Clifton-Cunningham Alana , Sadkowska Ania , Walker Sarah 
Published: September 2018

Abstract
Out of Hand: Materializing the Digital, Museum of Applied Art and Sciences, Sydney, 3 September 2016–25 June 2017
Units of Possibility: The Reknit Revolution, Amy Twigger Holroyd, Rugby Art Gallery & Museum, 24 June–2 September 2017, Rugby, UK
Crafts as serious hobbies: Impact and benefits in later life
Authors: Adams-Price Carolyn E. , Morse Linda W. 
Published: September 2018

Abstract
Although the creation of crafts by middle-aged and older adults is common across the globe, its significance has been overlooked in western culture. This article reviewed current research on the benefits of long-term participation in culturally meaningful creative arts and crafts (i.e., serious hobbies) and their impact on positive development in mid to late life. Creative hobbies are seen to have major benefits when practiced longterm. In addition, they often reflect aspects of one’s culture and the desire to add to that culture. A series of studies from the Synapse Project demonstrated that older adults who spent several hours a week for a few months learning to participate in a new craft activity showed improvements in their cognitive performance and neural efficiency as compared to control participants. Tomioka et al. found that participation in different types of groups, including hobby groups or volunteer groups, led to less decline in everyday functioning and independence among older adults. Adams-Price and colleagues investigated the impact of long-term practice of creative hobbies and found that serious participation in crafts may play a role in life satisfaction and successful ageing. Their work found four factors: (1) identity, (2) spirituality, (3) calming and (4) mastery/recognition from others. These factors impact life satisfaction through generativity, which is an important construct in Erikson’s theory of adult development. These studies and others, which are discussed, support the importance of crafts as a type of serious hobby that impacts cognitive and social well-being and life satisfaction among older individuals.