bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ältere Autofahrer: Gefahr oder Gefährdete?
Authors: Lukas Albert 
Published: May 2018

Was ist neu?
Bedeutung der Mobilität Zahlreiche Studien der letzten Jahre belegen die Bedeutung des Autofahrens für ältere Menschen, sowie dessen Einfluss auf das mentale, körperliche und soziale Wohlbefinden von Senioren.
Die aktuelle Unfallstatistik Nach den absoluten Unfallzahlen stellen ältere Autofahrer nach wie vor keine besonders auffällige Risikogruppe dar. Zwar stiegen in den letzten Jahren insgesamt die Unfallzahlen von Senioren, verglichen mit der Hochrisikogruppe der 18 – 24-Jährigen verursachen sie aber immer noch deutlich weniger Unfälle. Wenn Senioren allerdings einen Unfall verursachen, sind sie häufig die Hauptverursacher und tragen aufgrund ihrer höheren Vulnerabilität die schwereren Unfallfolgen.
Maßnahmen zur Sicherstellung Nach wie vor gibt es keinen wissenschaftlichen Beweis über den Nutzen regelmäßiger Fahrtauglichkeitsuntersuchungen ab einem bestimmten Alter.
Fahreignung und höheres Lebensalter Trainingsprogramme können eine gute Gelegenheit für ältere Verkehrsteilnehmer darstellen, auf altersbedingte physische und kognitive Veränderungen aufmerksam zu werden und zu reagieren.
Assessment der Fahreignung Das Sehvermögen, die Kognition und die motorische Funktion zählen zu den drei Schlüsseldomänen des Autofahrens. Nach wie vor ist nicht geklärt, welche Assessments am besten die Fahreignung eines Seniors abbilden. Am ehesten wird man ein ganzes Set unterschiedlicher kognitiver und funktioneller Assessments anwenden müssen. Goldstandard ist nach wie vor die Fahrprobe.
Die tubulointerstitielle Nephritis (medikamentös/infektiös)
Authors: Strutz Frank , Grupp Clemens 
Published: May 2018

Was ist neu?
Ursachen Bei der akuten Form der tubulointerstitiellen Nephritis (TIN) sind meist allergische Reaktionen auf Medikamente die Ursache, neben Antibiotika zunehmend auch Protonenpumpenhemmer. Bei den infektiösen Formen war zuletzt eine Zunahme von Hanta-Virus-Infektionen zu beobachten. Relativ neu beschrieben ist die IgG4-assoziierte Form.
Diagnostik Eine definitive Diagnose der TIN ist nur mittels Nierenbiopsie möglich. Diese wird selten gewonnen, sodass von einer hohen Dunkelziffer auszugehen ist. Die IgG4-assoziierte Form weist spezifische histologische Veränderungen auf. Essenziell ist eine sorgfältige Anamnese. Laborchemisch typisch, aber wenig spezifisch ist ein Anstieg der Retentionsparameter bei geringgradiger Proteinurie und nicht glomerulärer Hämaturie. Definitiv gesicherte Marker für das Vorliegen einer TIN sind bislang nicht validiert.
Therapie Die wichtigste therapeutische Maßnahme besteht im Ausschalten eines potenziellen Auslösers. Medikamentöse Therapie der ersten Wahl sind Glukokortikoide, obgleich die studienbasierte Evidenz sehr schmal ist und überwiegend auf älteren Daten beruht.
Surgical Pericardiectomy for Constrictive Pericarditis: A Single Tertiary Center Experience
Authors: Nachum Eyal , Sternik Leonid , Kassif Yigal , Raanani Ehud , Hay Ilan , Shalabi Amjad , Buber Jonathan 
Published: May 2018

Abstract
Background Although surgery is the sole therapeutic option for patients with constrictive pericarditis (CP), reports on high postoperative mortality rates have led to hesitant surgery referral. The aim of this study was to report the short- and long-term outcomes of surgical pericardiectomy (SP) from a large tertiary center.
Methods Between January 2005 and January 2017, 55 consecutive patients underwent SP after comprehensive echocardiography, computed tomography, and hemodynamic studies. Detailed clinical, imaging, surgical techniques and follow-up outcomes were recorded.
Results The most common etiology was idiopathic (n = 27, 49%) and 33 patients (60%) were in functional class 3/4. Sixteen patients (29%) underwent concomitant interventions during SP, and cardiopulmonary bypass (CPB) was used in these, as well as in four additional cases. Complete resection, independent of CPB, was achieved in 96%. One patient died during the index hospitalization, and four (7%) needed re-explorations due to bleeding. While 12 patients (22%) died during a mean follow-up of 52 ± 39 months, only 1 death was due to right heart failure. Functional class significantly improved (with a p-value < 0.001), diuretics were discontinued in all, and significant reductions of right atrial pressures were recorded. None of these outcomes differed as a result of concomitant interventions at the time of SP.
Conclusion Short- and long-term outcomes of SP, performed either alone or concomitantly with other procedures, indicate high safety and favorable clinical and hemodynamic efficacy for the treatment of CP.
Periphere arterielle Verschlusskrankheit – Entwicklungen zur Morbidität und Letalität in Deutschland
Authors: Malyar Nasser , Freisinger Eva , Reinecke Holger 
Published: May 2018

Was ist neu?
Morbidität der peripheren arteriellen Verschlusskrankheit Die Mehrheit der Patienten mit peripherer arterieller Verschlusskrankheit (pAVK) ist asymptomatisch. Bundesweite Analysen belegen einen überproportionalen Anstieg der pAVK, insbesondere des Anteils der Patienten mit einer schweren Form der pAVK, der sogenannten chronisch-kritischen Ischämie.
Trends hinsichtlich Risikofaktoren und Komorbiditäten, Amputation und Letalität Systematische Analysen zeigen, dass die Rate an Komorbiditäten und kardiovaskulären Risikofaktoren bei pAVK-Patienten stetig ansteigt, hier insbesondere Nieren- und Herzinsuffizienz. Verlaufsanalysen zeigen einen Rückgang der Major-Amputationsrate in den letzten Jahren, wenn auch auf Kosten eines Anstiegs der Minor-Amputationen. Die Gesamtzahl der ischämischen Amputationen bleibt jedoch weiterhin hoch (> 50 000/Jahr). Amputation und Letalität korrelieren mit dem klinischen Stadium (Schweregrad) der pAVK.
Ursachenforschung für die fehlende Prognoseverbesserung Die Prognose hinsichtlich Amputation und Letalität bei pAVK-Patienten ist im Vergleich zum historischen Kollektiv unverändert schlecht. Die spezifischen Ursachen dafür sind bisher nicht eindeutig geklärt, jedoch dürfte die mangelhafte Umsetzung der evidenzbasierten Therapieempfehlungen und Sekundärprävention eine wichtige Ursache und somit eine Zielgröße zukünftiger Therapiestrategie darstellen.
How social is the internet?
Authors: Mey Jacob L. 
Published: May 2018

Abstract
To many, the collocation of the terms ‘internet’ and ‘social’ may seem a bit strange, even contradictory. Either the internet is by definition social, or it is, by observation and intuition, a rather anti-social affair. The article tries to dispel this ambiguity of attribution, by focusing on both positive and negative aspects of internet practices, as we see them developing among its (often younger) users. A new vision of sociality is attributed mainly to the rise of the internet, and the consequences of a ‘fake’ social life are examined. Adaptation, both to the user and the soft/and hardware is seen as a key term in this respect, and some ethical and moral problems related to internet use are discussed with the aid of some actual cases. Finally, a general evaluation of the internet in both its positive and negative aspects is provided.
Breakfast at School: a First Look at the Role of Time and Location for Participation and Nutritional Intake
Authors: Moeltner Klaus , Spears Karen , Yu Ling 
Published: May 2018

AbstractParticipation in the subsidized School Breakfast Program has traditionally been unsatisfactory. Universally free breakfast service in the classroom has boosted participation, but is not financially feasible for many schools. Furthermore, it is unclear to what extent participation under the standard cafeteria setting is hampered due to insufficient time to eat. This study separately identifies time and location effects using a unique, individual‐level panel data set of elementary school students under three experimental treatments: original setup in the cafeteria, original setup plus ten minutes of mandatory presence in the cafeteria, and in‐classroom service. We find that the extra time plus the fixed location effect in the cafeteria increases average daily participation by approximately 20%, while the transition to classroom implementation adds another 35%–45% for the typical student. We also collect detailed data on nutritional intake, and find that, in total, neither treatment has a significant effect on consumption compared to the baseline.
Optimal Tenurial Contracts Under Both Moral Hazard and Adverse Selection
Authors: At Christian , Thomas Lionel 
Published: May 2018

AbstractThis paper determines the optimal tenurial contract between a monopoly landlord and a tenant protected by limited liability under both adverse selection (based on the tenant's ability) and moral hazard (based on the tenant's choice of effort). We identify different optimal contracts depending on the tenant's outside option. For intermediate values, there is a threshold of tenant ability depending on the outside option level below which the optimal contract is a separating sharecropping contract, and a pooling one otherwise. We also find that an increase in the outside option does not monotonically increase the tenant's optimal effort.
deepNF: deep network fusion for protein function prediction
Authors: Gligorijević Vladimir , Barot Meet , Bonneau Richard 
Published: May 2018

Abstract

Motivation
The prevalence of high-throughput experimental methods has resulted in an abundance of large-scale molecular and functional interaction networks. The connectivity of these networks provides a rich source of information for inferring functional annotations for genes and proteins. An important challenge has been to develop methods for combining these heterogeneous networks to extract useful protein feature representations for function prediction. Most of the existing approaches for network integration use shallow models that encounter difficulty in capturing complex and highly non-linear network structures. Thus, we propose deepNF, a network fusion method based on Multimodal Deep Autoencoders to extract high-level features of proteins from multiple heterogeneous interaction networks.

Results
We apply this method to combine STRING networks to construct a common low-dimensional representation containing high-level protein features. We use separate layers for different network types in the early stages of the multimodal autoencoder, later connecting all the layers into a single bottleneck layer from which we extract features to predict protein function. We compare the cross-validation and temporal holdout predictive performance of our method with state-of-the-art methods, including the recently proposed method Mashup. Our results show that our method outperforms previous methods for both human and yeast STRING networks. We also show substantial improvement in the performance of our method in predicting gene ontology terms of varying type and specificity.

Availability and implementation
deepNF is freely available at: https://github.com/VGligorijevic/deepNF.

Supplementary information
Supplementary data are available at Bioinformatics online.
Parental Decision-Making and Deaf Children: A Systematic Literature Review
Authors: Porter Ann , Creed Peter , Hood Michelle , Ching Teresa Y C 
Published: May 2018

AbstractParents or caregivers of children who are deaf or hard of hearing are required to make complex and rational decisions soon after the confirmation of hearing loss. Ways of facilitating decision-making have been a focus within the healthcare sector for two decades and shared decision-making is now widely viewed as the standard for good clinical care. A systematic literature review was undertaken to identify the extent to which the principles of shared decision-making and informed choice have been implemented for parents when they make decisions related to their children with permanent hearing loss. Five databases were searched for peer-reviewed papers describing the results of original research published from 2000 to 2017, yielding 37 relevant papers. Studies were reviewed using the three phases of decision-making—information exchange, deliberation, and implementation. Two decisions dominated these studies—implantable devices and communication modality. Most papers dealt with decision-making in the context of bilateral hearing loss, with only one study focusing on unilateral hearing loss. The review identified gaps where further research is needed to ensure the lessons learnt in the broader decision-making literature are implemented when parents make decisions regarding their child who is deaf or hard of hearing.
mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles
Authors: Malge Anjali , Ghai Vikas , Reddy Panga Jaipal , Baxter David , Kim Taek-Kyun , Moritz Robert L , Wang Kai 
Published: May 2018

Abstract
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. Borrelia burgdorferi has a linear chromosome with a number of circular and linear plasmids. Bacteria, including B. burgdorferi, release spherical outer membrane vesicles (OMVs) that are known to carry secretory products including metabolites, nucleic acids and proteins. Herein, we provide the first comparative transcriptomic analysis of the vesicles released from B. burgdorferi. We identified a total of ∼1200 unique transcripts with at least one mapped read from the bacterial cell and its OMVs. We compared the spectrum of transcripts between bacterial cell and its OMVs, and found a biased distribution based on the source of transcripts, i.e. plasmid-encoded transcripts are more likely to be enriched in the OMVs. We validated the distribution for some of the transcripts by qPCR. This analysis provides the first evidence that some of the B. burgdorferi transcripts are preferentially packaged in OMV, which further suggest that the bacteria might use its OMVs for bacteria–bacteria or bacteria–host communications. This report also suggests a possible involvement of Borrelia-derived OMVs in the development of Lyme disease in both early and post disease syndromes.
Effects of patient safety auditing in hospital care: results of a mixed-method evaluation (part 1)
Authors: Hanskamp-Sebregts Mirelle , Zegers Marieke , Westert Gert P , Boeijen Wilma , Teerenstra Steven , van Gurp Petra J , Wollersheim Hub 
Published: May 2018

Abstract

Objective
To evaluate the effectiveness of internal auditing in hospital care focussed on improving patient safety.

Design, Setting and Participants
A before-and-after mixed-method evaluation study was carried out in eight departments of a university medical center in the Netherlands.

Intervention(s)
Internal auditing and feedback focussed on improving patient safety.

Main Outcome Measure(s)
The effect of internal auditing was assessed 15 months after the audit, using linear mixed models, on the patient, professional, team and departmental levels. The measurement methods were patient record review on adverse events (AEs), surveys regarding patient experiences, safety culture and team climate, analysis of administrative hospital data (standardized mortality rate, SMR) and safety walk rounds (SWRs) to observe frontline care processes on safety.

Results
The AE rate decreased from 36.1% to 31.3% and the preventable AE rate from 5.5% to 3.6%; however, the differences before and after auditing were not statistically significant. The patient-reported experience measures regarding patient safety improved slightly over time (P < 0.001). The SMR, patient safety culture and team climate remained unchanged after the internal audit. The SWRs showed that medication safety and information security were improved (P < 0.05).

Conclusions
Internal auditing was associated with improved patient experiences and observed safety on wards. No effects were found on adverse outcomes, safety culture and team climate 15 months after the internal audit.
Simultaneous Determination of Amphetamine-Related New Psychoactive Substances in Urine by Gas Chromatography–Mass Spectrometry†
Authors: Kim Jin Young , Suh Sunglll , Park Jaehyeong , In Moon Kyo 
Published: May 2018

AbstractDespite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substances in biological samples. The objective of this study was to develop and validate the gas chromatography–mass spectrometric (GC–MS) method for the simultaneous determination of 13 amphetamine-related NPS (amphetamine; AP, 4-fluoroamphetamine; 4FA, methamphamine; MA, 4-fluoromethamphetamine; 4FMA, 4-chloroamphetamine; 4CA, para-methoxyamphetamine; PMA, 4-chloromethamphetamine; 4CMA, 6-(2-aminopropyl)benzofuran; 6APB, 4-methylenedioxyamphetamine; MDA, para-methoxymethamphetamine; PMMA, 6-(2-methylaminopropyl)benzofuran; 6MAPB, 3,4-methylenedioxymethamphetamine; MDMA, 5,6-methylenedioxy-2-aminoindane; MDAI) in urine. The analytes were extracted at pH 7.4 by liquid–liquid extraction prior to their trifluoroacetyl derivatives and then analyzed by GC–MS. The validation parameters included selectivity, linearity, lower limits of quantification (LLOQ), intra and interday precision and accuracy, recovery and stability. The linear ranges were 2–100 ng/mL for AP, 4FA, 4FMA, 4CA, PMA, 6APB, MDA, and MDAI, 2–250 ng/mL for 4CMA, PMMA, and 6MAPB and 25–1,000 ng/mL for MA and MDMA, with acceptable coefficients of determination (r2 > 0.9963). The intra and interday precision were within 11.9 and 12.5%, while the intra and interday accuracies ranged from −10.6% to 13.0% and −11.0% to 6.8% for the nominal concentration at all studied levels, respectively. The LLOQs for each analyte were 2.0–25 ng/mL. The recoveries ranged from 69.3% to 96.4%. The short- and long-term variations of the analytes in urine were lower than 8.5 and 12.7%, indicating that the analytes are stable at least for 16 h at room temperature and for 7 days at 4°C, respectively. The applicability of the method was examined by analyzing urine samples from drug abusers and was determined to be effective for detecting multiple drug use.
Philhellenic attitudes. Eduard Schaubert’s Wrocław collection: an account of its antiquities and the circumstances of its formation
Authors: Kubala Agata 
Published: May 2018

Abstract
This paper considers the figure of the Wrocław collector Eduard Schaubert (1804–1860) and the collection he amassed during his twenty-year stay in Greece, paying particular attention to his collecting activities and the motives that lay behind them. The collection was built up over at least a dozen years and was gradually expanded in two ways: through personal exploration in Athens and in other regions of Greece, and through purchases. Schaubert’s collection forms an expression of its creator’s philhellenic attitudes and an example of a new, scholarly approach to collecting in which artefacts were chosen according to a pre-defined principle. It also represents an interesting example of a markedly heterogeneous group, comprising not only Greek objects but also items of Egyptian and Roman provenance, so forming what might be described as a typical nineteenth-century private collection of antiquities.
Urinary [TIMP-2]·[IGFBP7]-guided randomized controlled intervention trial to prevent acute kidney injury in the emergency department
Authors: Schanz Moritz , Wasser Christoph , Allgaeuer Sebastian , Schricker Severin , Dippon Juergen , Alscher Mark Dominik , Kimmel Martin 
Published: May 2018

Abstract

Background
Early detection and prevention of acute kidney injury (AKI) is important to reduce morbidity and mortality. Discovery of early-detection biomarkers has enabled early preventive approaches. There are no data on early biomarker-guided intervention with nephrological consultation in emergency departments (EDs).

Methods
In this prospective randomized controlled intervention trial, patients at high risk for AKI were screened with urinary [TIMP-2]·[IGFBP7] in the ED of Robert-Bosch-Hospital (Stuttgart, Germany). We screened 257 eligible patients of whom 100 met the inclusion criteria, with urinary [TIMP-2]·[IGFBP7] >0.3, and were included. The intervention group received immediate one-time nephrological consultation after randomization, implementing Kidney Disease: Improving Global Outcomes (KDIGO) 2012 recommendations on AKI. The primary outcome was the incidence of moderate to severe AKI within the first day after admission. Secondary outcomes were AKI occurrence within 3 days after admission, need for renal replacement therapy (RRT), length of hospital stay and death.

Results
The primary outcome did not differ significantly (P = 0.9) between the groups, neither within the first day nor within the first 3 days after admission. The intervention group had significantly (P < 0.05) lower serum creatinine (SCr) on Day 2 and lower maximum SCr and tended (P = 0.08) to have higher urine output (UOP) at Day 3 than the non-intervention group. No patient in the intervention group needed RRT (0 versus 3) during the hospital stay (P = 0.09).

Conclusions
One-time routine nephrologist-guided application of the KDIGO bundle in ED patients with a risk for AKI cannot currently be recommended. However, due to the uniform trend of study endpoints in favour of intervention, further trials to investigate larger cohorts of more severely ill patients are warranted.

Trial registration
www.ClinicalTrials.gov, study number NCT02730637.
Money, Sex and Broken Promises: Politicians’ Bad Behaviour Reduces Trust
Authors: Rose Richard , Wessels Bernhard 
Published: May 2018

AbstractThis article develops and tests empirically a theory of the effect on political trust of forms of behaviour that violate social, political and legal norms about how politicians ought to behave. These include taking money for favours, over-indulging in private life and making misleading promises to win votes. The evidence comes from a specially designed survey in Britain, France and Spain, countries where popular distrust of politicians appears greater than illegal political behaviour. Bad behaviours, especially abandoning election promises once in office, have a much stronger effect on distrust of political parties that do differences in partisanship. Comparing national regressions shows that the impact of bad behaviours is very similar in Britain, France and Spain.