bluuebunny/crossref_metadata_2025_split huggingface dataset:
Al atomistic surface modulation on colloidal gradient quantum dots for high-brightness and stable light-emitting devices
Authors: Lee Jae-Sung , Kang Byoung-Ho , Kim Sae-Wan , Kwon Jin-Beom , Kim Ok-Sik , Byun Young Tae , Kwon Dae-Hyuk , Bae Jin-Hyuk , Kang Shin-Won 
Published: April 2019

AbstractQuantum-dot (QD) light-emitting devices (QLEDs) have been attracting considerable attention owing to the unique properties of process, which can control the emission wavelength by controlling the particle size, narrow emission bandwidth, and high brightness. Although there have been rapid advances in terms of luminance and efficiency improvements, the long-term device stability is limited by the low chemical stability and photostability of the QDs against moisture and air. In this study, we report a simple method, which can for enhance the long-term stability of QLEDs against oxidation by inserting Al into the shells of CdSe/ZnS QDs. The Al coated on the ZnS shell of QDs act as a protective layer with Al2O3 owing to photo-oxidation, which can prevents the photodegradation of QD with prolonged irradiation and stabilize the device during a long-term operation. The QLEDs fabricated using CdSe/ZnS/Al QDs exhibited a maximum luminance of 57,580 cd/m2 and current efficiency of 5.8 cd/A, which are significantly more than 1.6 times greater than that of CdSe/ZnS QDs. Moreover, the lifetimes of the CdSe/ZnS/Al-QD-based QLEDs were significantly improved owing to the self-passivation at the QD surfaces.
Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease
Authors: Hénaut Lucie , Grissi Maria , Brazier François , Assem Maryam , Poirot-Leclercq Sabrina , Lenglet Gaëlle , Boudot Cédric , Avondo Carine , Boullier Agnès , Choukroun Gabriel , Massy Ziad. A , Kamel Saïd , Chillon Jean-Marc 
Published: April 2019

AbstractIschemic stroke is highly prevalent in chronic kidney disease (CKD) patients and has been associated with a higher risk of neurological deterioration and in-hospital mortality. To date, little is known about the processes by which CKD worsens ischemic stroke. This work aimed to investigate the cellular and molecular mechanism associated with ischemic stroke severity in an in vivo model of CKD. CKD was induced through right kidney cortical electrocautery in 8-week-old female C57BL/6 J mice followed by left total nephrectomy. Transient middle cerebral artery occlusion (tMCAO) was performed 6 weeks after left nephrectomy. Twenty-four hours after tMCAO, the infarct volumes were significantly wider in CKD than in SHAM mice. CKD mice displayed decreased neuroscore, impaired ability to remain on rotarod device, weaker muscular strength and decreased prehensile score. Apoptosis, neuronal loss, glial cells recruitment and microglia/macrophages M1 signature genes CD32, CD86, IL-1β, IL-6, MCP1 and iNOS were significantly increased within ischemic lesions of CKD mice. This effect was associated with decreased AMP kinase phosphorylation and increased activation of the NFΚB pathway. Pharmacological targeting of AMP kinase activity, which is known to block microglia/macrophages M1 polarization, appears promising to improve stroke recovery in CKD.
Changes in the intestine microbial, digestion and immunity of Litopenaeus vannamei in response to dietary resistant starch
Authors: Duan Yafei , Wang Yun , Liu Qingsong , Dong Hongbiao , Li Hua , Xiong Dalin , Zhang Jiasong 
Published: April 2019

AbstractResistant starch (RS) is a constituent of dietary fibre that has beneficial effects on the intestine physiological function of animals. However, the roles of RS on shrimp intestine health is unknown. In this study, we investigated the the effects of dietary RS on the microbial composition, and digestive and immune-related indices in the intestine of Litopenaeus vannamei. The shrimp were fed with diets containing different levels of RS: 0 g/kg (Control), 10 g/kg (RS1), 30 g/kg (RS2) and 50 g/kg (RS3) for 56 days. The results showed that dietary RS improved the morphology of the intestine mucosa. RS also increased the activity of digestive enzymes (AMS, LPS, Tryp, and Pep) and immune enzymes (PO, T-AOC, T-NOS, and NO), and the expression levels of immune-related genes (proPO, ALF, Lys, HSP70, Trx, Muc-1, Muc-2, Muc-5AC, Muc-5B, and Muc-19). A microbiome analysis indicated that dietary RS increased the short-chain fatty acids (SCFAs) contents and altered the composition of the intestine microbial. Specifically, RS increased the abundances of Proteobacteria and decreased the abundance of Bacteroidetes. At the genus level, the beneficial bacteria (Lutimonas, Ruegeria, Shimia, Mesoflavibacter, and Mameliella) were enriched, which might be involved in degrading toxins and producing beneficial metabolites; while potential pathogens (Formosa and Pseudoalteromonas) were decreased in response to dietary RS. Our results revealed that dietary RS could improve the intestine health of L. vannamei, probably via modulating the intestine microbial composition and SCFAs contents, and enhancing the digestion and immunity of the shrimp.
Genome-wide patterns of population structure and association mapping of nut-related traits in Persian walnut populations from Iran using the Axiom J. regia 700K SNP array
Authors: Arab Mohammad Mehdi , Marrano Annarita , Abdollahi-Arpanahi Rostam , Leslie Charles A. , Askari Hossein , Neale David B. , Vahdati Kourosh 
Published: April 2019

AbstractPersian plateau (including Iran) is considered as one of the primary centers of origin of walnut. Sampling walnut trees originating from this arena and exploiting the capabilities of next-generation sequencing (NGS) can provide new insights into the degree of genetic variation across the walnut genome. The present study aimed to explore the population structure and genomic variation of an Iranian collection of Persian walnut (Juglans regiaL.) and identify loci underlying the variation in nut and kernel related traits using the new AxiomJ. regia700K SNP genotyping array. We genotyped a diversity panel including 95 walnut genotypes from eight Iranian provinces with a variety of climate zones. A majority of the SNPs (323,273, 53.03%) fell into the “Poly High Resolution” class of polymorphisms, which includes the highest quality variants. Genetic structure assessment, using several approaches, divided the Iranian walnut panel into four principal clusters, reflecting their geographic partitioning. We observed high genetic variation across all of the populations (HO = 0.34 and HE = 0.38). The overall level of genetic differentiation among populations was moderate (FST = 0.07). However, the Semnan population showed high divergence from the other Iranian populations (on average FST = 0.12), most likely due to its geographical isolation. Based on parentage analysis, the level of relatedness was very low among the Iranian walnuts examined, reflecting the geographical distance between the Iranian provinces considered in our study. Finally, we performed a genome-wide association study (GWAS), identifying 55 SNPs significantly associated with nut and kernel-related traits. In conclusion, by applying the novel AxiomJ. regia700K SNP array we uncovered new unexplored genetic diversity and identified significant marker-trait associations for nut-related traits in Persian walnut that will be useful for future breeding programs in Iran and other countries.
Visual Performance in Eyes Undergoing Femtosecond Laser-Assisted Keratoplasty for Advanced Keratoconus
Authors: Kamiya Kazutaka , Takahashi Masahide , Igarashi Akihito , Shoji Nobuyuki 
Published: April 2019

AbstractThis study was aimed to compare visual performance in eyes having femtosecond laser-assisted keratoplasty (FLAK) for grade 4 keratoconus and keratoconic eyes according to the Amsler-Krumeich classification. We comprised 15 eyes of 15 patients undergoing FLAK for grade 4 keratoconus and 69 of 69 keratoconic patients (grade 1; 26 eyes, 2; 17 eyes, 3; 10 eyes, and 4; 16 eyes), and compared best spectacle-corrected visual acuity (BSCVA), corneal astigmatism (CA), corneal densitometry (CD), and corneal higher-order aberrations (CHOAs) using the Scheimpflug rotating camera. BSCVA in the post-FLAK group was significantly better than that in grade 3 or 4 group, but not than that in grade 1 or 2 group. CA was significantly lower than that in grade 3 or 4 group, but not than that in grade 1 or 2 group. CD was significantly higher than that in grade 1, 2, and 3 group, and significantly lower than that in grade 4 group. CHOAs were significantly lower than that in grade 3 or 4 group, but not than that in grade 1 or 2 group. FLAK showed significantly better BSCVA, and less CA and CHOAs, than grade 3 or 4 keratoconus, and showed less CD than grade 4 keratoconus.
Down-regulation of lncRNA-NEF indicates poor prognosis in intrahepatic cholangiocarcinoma
Authors: Liang Zhanqiang , Zhu Bingshuai , Meng Dongdong , Shen Xiwen , Li Xuemin , Wang Zhongzhen , Li Liantao 
Published: April 2019

Abstract
LncRNA-NEF is a tumor suppressor lncRNA in liver cancer. The present study aimed to investigate the role of lncRNA-NEF in intrahepatic cholangiocarcinoma (IHCC), which is second most common type of primary cancer of the hepatobiliary system that causes high mortality rate. In the present study we found that lncRNA-NEF was down-regulated, while Runt-related transcription factor 1 (RUNX1) was up-regulated in tumor tissues than in adjacent healthy tissues of IHCC patients. Expression levels of lncRNA-NEF and RUNX1 were significantly and reversely correlated in tumor tissues but not in adjacent healthy tissues. Plasma levels of lncRNA-NEF were significantly lower in IHCC patients than in healthy controls. Down-regulation of lncRNA-NEF effectively distinguished stage I and II IHCC patients from healthy controls. Patients were followed up for 5 years, patients with high plasma levels of lncRNA-NEF showed significantly better survival conditions compared with patients with low expression levels of lncRNA-NEF. LncRNA-NEF overexpression led to inhibited expression of RUNX1 in cells of IHCC cell lines and inhibited cancer cell migration and invasion. In contrast, RUNX1 overexpression showed no significant effects on lncRNA-NEF expression, but attenuated the effects of lncRNA-NEF overexpression on cancer cell migration and invasion. We therefore concluded that lncRNA-NEF participated in IHCC possibly by interacting with RUNX1.
Vocal Development in Infants and Toddlers With Bilateral Cochlear Implants and Infants With Normal Hearing
Authors: Välimaa Taina T. , Kunnari Sari M. , Laukkanen-Nevala Päivi , Ertmer David J. 
Published: April 2019

PurposeThe purpose of this study was to investigate the time course of vocal development in infants and toddlers with bilateral cochlear implants (CIs; bilateral CI group) who are acquiring Finnish and to compare their progress to that of infants with normal hearing and typical development (TD group).MethodFive thousand nine hundred sixty-four spontaneous utterances of 30 infants and toddlers (15 in both groups) were classified as either precanonical (PC) vocalizations, basic canonical syllables (BCS), or advanced forms (AF) levels. Time course of development and group differences were analyzed in a prospective longitudinal study during a time course of 1 year: before implantation and 1, 3, 6, 9, and 12 months after CI activation for the bilateral CI group and at 6, 9, and 12 months of age for the TD group.ResultsThe least mature PC vocalizations decreased and the BCS and AF vocalizations increased for both the bilateral CI and TD groups during the follow-up period of 1 year. The bilateral CI group produced a lower percentage of PC vocalizations (effect size, ηp2= .35) and a higher percentage of BCS (effect size, ηp2= .16) and AF vocalizations (effect size, ηp2= 0.24) than the TD group.ConclusionsThe findings of this study showed that vocal development of infants and toddlers with early-identified profound hearing loss is delayed before CI activation. Findings also showed that infants and toddlers with bilateral CIs make rapid advancements in vocal development after implantation compared to infants with typical development. However, their vocal development seems to remain delayed at least during the 1st year of bilateral CI use as compared to the well-documented milestones of infants and toddlers with typical development. Information about the vocal development time course following bilateral CI activation helps parents recognize progress in auditory-guided speech development before the emergence and the use of spoken words in communication.
„Genesung bedeutet nicht Restitution einer alten, sondern Genesis einer neuen Gesundheit“
Authors: Matthiessen Peter F. , Irnich Dominik , Niklas Anke 
Published: April 2019

SummaryUm eine umfassende Erkenntnis unserer Patienten zu gewinnen, bedeutet die Herausforderung, ihnen aus unterschiedlichen Sichtweisen und mit verschiedenen Erkenntnismethoden zu begegnen – unvoreingenommen, einfühlsam und wertschätzend
Urospermia indicating ectopic ureters in breeding dogs – 3
cases
Authors: Günzel-Apel Anne-Rose , Wolf Karola , Beining Franziska Werhahn , Baumeister Anke , Bach Jan-Peter , Hungerbühler Stephan , Nickel Rafael 
Published: April 2019

AbstractAn Entlebucher Mountain Dog (57 months old, case 1), a Labrador Retriever (24
months, case 2) and an Irish Soft-Coated Wheaten Terrier (31 months old, case 3)
were presented for breeding soundness evaluation to the clinic. During semen
collection in all 3 dogs, the pre-secretion and the sperm-rich fraction showed
normal consistency and colour, whereas the prostatic secretion (3 rd ejaculate
fraction) appeared strikingly yellow. In cases 1 and 2, a severely decreased
sperm motility (asthenozoospermia) and an increased amount of abnormal
spermatozoa (teratozoospermia), and in case 3, a moderately decreased total
sperm count (oligozoospermia) were detected. Sonographical examination revealed
abnormal findings regarding the uretero-vesical junction and ectopic ureters.
Therefore it is concluded that urine admixture to the 3 rd ejaculate fraction
may indicate the presence of ectopic ureters and may cause impairment of semen
quality and fertility. The present cases raise questions regarding urospermia
concerning: 1. its incidence in dogs in general and in connection with ectopic
ureters and 2. its relevance as a cause of deficient ejaculate quality and
subfertility or infertility.
Therapie des akuten viralen
Katzenschnupfens
Authors: Bergmann Michèle , Ballin Anne , Schulz Bianka , Dörfelt René , Hartmann Katrin 
Published: April 2019

ZusammenfassungDie Haupterreger des Katzenschnupfens, das feline Herpesvirus-1 (FHV-1) und das
feline Calicivirus (FCV), sind in Katzenpopulationen weit verbreitet, vor allem
in Haushalten mit vielen Katzen auf engem Raum. Katzen mit schweren klinischen
Symptomen müssen meist stationär behandelt werden. Eine intensive symptomatische
Therapie wirkt sich positiv auf den Heilungsverlauf aus. Der Einsatz antiviraler
Medikamente bei Katzen ist limitiert, da viele der Substanzen unwirksam oder bei
systemischer Gabe toxisch sind. Antivirale Medikamente werden daher vor allem
lokal zur Therapie FHV-1-assoziierter Augenveränderungen eingesetzt. Famciclovir
ist jedoch als wirksames Virostatikum zur systemischen Therapie bei Katzen mit
FHV-1-bedingten Symptomen geeignet. Gegen FCV sind nur wenige antivirale
Medikamente verfügbar. Der Einsatz von Immunglobulinen führte in einer
kontrollierten Studie bei Katzen mit FHV-1- und/oder FCV-Infektion zu einer
signifikant schnelleren Besserung der Symptome eines akuten
Katzenschnupfens.
Schulter-Arm-Schmerzen aus neuro-orthopädischer Sicht
Authors: Rommel Oliver , Jäger Georg 
Published: April 2019

SummarySchulter-Arm-Schmerzen können Folge unterschiedlicher Erkrankungen aus dem neurologischen und orthopädischen Fachgebiet sein. Symptome von Seiten des Nervensystems sowie von Gelenken und Weichteilen können einander überlappen und sich beeinflussen. Daher ist eine sorgfältige Diagnostik notwendig.Die 3 vorgestellten Kasuistiken zeigen die Vielfalt der zugrunde liegenden Erkrankungen, die zu Schulter-Arm-Schmerzen führen können. Therapeutisch steht ein breites Spektrum von medikamentösen, physiotherapeutischen, naturheilkundlichen, infiltrativen und operativen Verfahren zur Verfügung.
National Multicenter and Multiyear Review of Complications Following Fluoroscopic Gastrostomy in Patients Covered by Medicare and Medicaid
Authors: Khalid Syed , Wu Rita , Tasse Jordan , Tabriz David , Madassery Sreekumar , Turba Ulku , Arslan Bulent 
Published: April 2019

Abstract
Objective This study aims to assess the postoperative complication rates associated with fluoroscopically placed gastrostomy tubes.
Background Fluoroscopically placed gastrostomy tubes are a relatively common procedure performed by interventional radiologists. Few studies have been performed in the United States to access the complication profile of fluoroscopically placed gastrostomy tubes.
Methods Total 51 million Medicare Standard Analytic Patient Records derived from Medicare parts A and B records from 2007 to 2012 were retrospectively analyzed. Only the patients undergoing fluoroscopic gastrostomy were included in this study. Patient demographics were stratified by age, sex, comorbidities, and peri- and postoperative complications as defined by International Classification of Diseases (ICD) 9 codes.
Results Total 30,327 patients undergoing fluoroscopic gastrostomy were analyzed. Perioperative complications following these procedures were low, with 61 (0.02%) patients experiencing pneumoperitoneum, 130 (0.43%) experiencing ileus, 16 (0.05%) experiencing esophageal/gastric perforation, and 30 (0.09%) patients experiencing intra-abdominal injury. Most common postoperative complications included abdominal wall pain (n = 2,808, 9.25%), bleeding (n = 1,353, 4.46%), and mechanical complications (n = 1,435, 4.73%).
Conclusion Fluoroscopic guidance is a safe method for gastrostomy placement, with exceedingly low rates of peri- and postoperative complications.
Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment
Authors: Li Xiao-Li , Liu Yun , Liu Miao , Yang Chun-Yan , Yang Qiao-Zhi 
Published: April 2019

Abstract
Objective This study aimed to explore the clinical significance of early premature infant oral motor intervention (PIOMI) in the prognosis of premature infants.
Study Design Infants were randomly divided into an intervention group (n = 78) and a control group (n = 73). PIOMI was given to the intervention group 15 to 30 minutes before feeding once a day for 14 days. The whole procedure lasted 15 minutes, including oral stimulation and nonnutritive sucking. Oral feeding ability and neuromotor development were evaluated using the Preterm Infant Oral Feeding Readiness Assessment (PIOFRA) scale and Infant Neurological International Battery (Infanib) scale.
Results The PIOFRA score was higher in the intervention group and increased with time, showing a group–time interaction effect. The intervention group exhibited a higher feeding efficiency, a shorter transition time from assisted oral feeding to independent oral feeding, and lower body weight at achievement of independent oral feeding. The percentages of infants with a normal score on the Infanib scale were higher in the intervention group at 3 and 6 months of age, and an abnormal ratio was lower in the intervention group at 6 months (p < 0.01).
Conclusion PIOMI promoted neuromotor coordination by improving neurodevelopment, thereby improving the oral feeding ability and prognosis of preterm infants.
A neural signature of pattern separation in the monkey hippocampus
Authors: Sakon John J. , Suzuki Wendy A. 
Published: April 2019

SignificanceWhen a person experiences a stimulus similar to one held in recent memory, the brain is tasked to discriminate these overlapping representations. This process is termed pattern separation. We evoked this process in monkeys by having them serially view novel, repeat, and similar images, and could reliably predict which of these three stimuli they were viewing from electrophysiological responses of their hippocampal neurons. Neurons that best identify images fall into two stereotyped response patterns, with only one group able to distinguish similar vs. repeat images, the crucial pattern separation probe. These results show a neural signature in hippocampus indicative of pattern separation, which will contribute to our understanding of how the brain recognizes differences in the service of making memories.
Ethics and aesthetics are one
Authors: Kwok Virginia 
Published: April 2019

Abstract
In the post-modern world where thinking of pluralism and relativism is prevalent (Honeysett 2002), fundamental values such as respect for life pertinent to the health and welfare of
humanity should remain unchanged in order to preserve the culture from corrosion. In this paper, through examining creativity in
translation and creative writing (Zawawy 2008; Perteghella and Loffredo 2006), macro- and micro- strategies of translating a Chinese prose into an English play will
be discussed, with the aim to explore the notion, “creativity is culturally variable” (Carter
2016) in literary translation. I would concur with Ludwig Wittgenstein who stated, “ethics and aesthetics are one” (1961), and argue that genres and forms of expression might vary in cross-cultural translation, semantic content and message
should still be unaltered. Literary translators can act as cultural mediators to advocate peace. So to “develop an understanding
of translation strategies and of the vital role that creativity plays throughout the translation/interpreting process” (Levý in
Beylard-Ozeroff, Králová and Moser-Mercer 1998) can help translators build bridges
rather than promote violence, to foster diversity rather than divisiveness. As such, I would explore how a translator can
translate cultures with respect, integrity and creativity in the midst of tensions, confrontations and conflicts due to
misunderstandings linguistically and culturally. As Vezzaro (2010: 10) put it, “to come
closer to feeling compassion, which is what writing and translating is ultimately all about.” This will call for efforts to
translate texts with faithfulness and the right degree of creativity (Grassilli 2014),
making good decisions at individual levels and beyond. This will also require cultural understanding and collaboration at national
and even international levels.
Into the deep blue sea: A review of the safety of recreational diving in people with diabetes mellitus
Authors: Koufakis Theocharis , Karras Spyridon N. , Mustafa Omar G. , Karangelis Dimos , Zebekakis Pantelis , Kotsa Kalliopi 
Published: April 2019

AbstractPeople with diabetes, particularly those being insulin treated, have been for many years considered ineligible for diving, because of the high risk of adverse events. Blood glucose levels tend to decline during diving, probably because of changes in insulin requirements and resistance, due to increased physical activity and effects of hyperbaric environment on glucose tolerance. Strict adherence to safety protocols, in conjunction with optimal physical status, lack of diabetic complications (especially impaired awareness of hypoglycaemia) and satisfactory baseline glycaemic control, seem to minimise the risk of complications during diving. The integration of modern technology into diabetes management, providing potential for underwater continuous glucose monitoring, can be useful in optimising metabolic control before, during and after diving. Despite the significant progress been made on safety issues, there is still a need to implement the relevant recommendations into divers’ everyday practice. Existing evidence is mainly derived from small studies and there is a wide heterogeneity in terms of study designs and explored outcomes, rendering the extraction of definitive conclusions challenging. The aim of this review is to present and critically evaluate available evidence, use of technology, and gaps in existing knowledge that deserve further evaluation by future studies.