bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines
Authors: Mendis Anuka S. , Thabrew Ira , Ediriweera Meran K. , Samarakoon Sameera R. , Tennekoon Kamani H. , Adhikari Achyut , de Silva Egodage D. 
Published: November 2018

Background/Objective:
Vernonia zeylanica (L) less is an endemic plant to Sri Lanka. The present
study was designed to isolate potential cytotoxic compound/s from chloroform and ethyl acetate extracts of V.
zeylanica by bio-activity guided isolation and to evaluate its anti-proliferative effects in three breast cancer
phenotypes (MCF -7, MDA-MB-231, SKBR-3).

Methods:
Combined chloroform and ethyl acetate extracts were subjected to chromatographic separations to
isolate a compound (1) and the structure of the isolated compound was elucidated using 1H, 13C and mass spectroscopic
techniques. Cytotoxic effects of the compound were evaluated by the sulforhodamine B (SRB) and the
MTT (3- (4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. Effects of the compound on
apoptosis were evaluated by fluorescent microscopy, caspase 3/7 activation, DNA fragmentation and real time
PCR. Effects of the compound on the expression of heat shock protein complex were also evaluated by real time
PCR and immunofluorescence.

Results:
Isolated compound was identified as a new sesquiterpene lactone (vernolactone). The compound mediated
significant cytotoxic effects in SKBR-3 and MDA-MB-231 breast cancer cells, with little effect in MCF-7
and normal mammary epithelial MCF-10A cells. Morphological changes, DNA fragmentation, increased
caspase 3/7 activities and up-regulation of p53, Bax and down regulation of Survivin confirmed the proapoptotic
effects of the compound. Significant inhibition of HSP complex related genes were also observed in SKBR-3
and MDA-MB-231 breast cancer cells.

Conclusion:
Overall results indicate that vernolactone can mediate its cytotoxic effects via apoptosis and modulating
the HSP complex.
Drugs of Abuse Induced-Subversion of the Peripheral Immune Response and Central Glial Activity: Focus on Novel Therapeutic Approaches
Authors: Magrone Thea , Jirillo Emilio 
Published: November 2018

Background:Drugs of abuse affect both central nervous system (CNS) and peripheral immune function. Besides the involvement of dopamine and glutamate systems, chronic exposure to drugs of abuse alters immune homeostasis, promoting a pro-inflammatory status. At the same time, impaired peripheral immunity leads to an increased susceptibility to infections in drug abusers.Discussion:There is evidence that certain drugs, such as opioids, activate microglial cells and astrocytes which, in turn, provoke central neuroinflammation. Particularly, opioids bind the Toll-like receptor (TLR)-4 with increased expression of nuclear factor kappa-light-chain-enhancer of activated B cells and release of pro-inflammatory cytokines. Peripheral mediators released by immune cells also contribute to aggravate central neuroinflammation.Conclusion:These are based either on the inhibition of TLR-4 activation by drugs of abuse or on the correction of dopamine and glutamate pathways. Finally, a hypothetic nutraceutical intervention with polyphenols in view of their anti-inflammatory and anti-oxidant properties will be outlined as an adjuvant treatment for drugs of abuse-related disorders.
A Triple-cycloconverter-based Soft-start Control Strategy Zh
Authors: Xu Zhengwang , Yi Yuchun , Sun Yutong , Zhang Jiarui , Chen Cheng , Yu Jiaqi , Mei Wei , Wan Xiangkui 
Published: November 2018

Objective:
The use of multiple-stage cycloconverters is suitable for variable-frequency
speed control of high-voltage, large-capacity motors, for which it is sometimes necessary to establish
separate controls for variable-frequency operation and the start-up phase. This approach effectively
limits the starting current of the large-capacity motor by switching the phase relationship of
the triple circuit’s output voltages to control the overall output voltage.

Methods:
We analyze a triple circuit using voltage vector analysis and simulation analysis with
MATLAB modeling.

Results:
We find that our triple soft-start control strategy can be applied to large-capacity motors, as
this strategy results in a pure sine wave output voltage and current, and maintains balance in the
three-phase voltage during startup.

Conclusion:
In order to further decrease these types of effects, we will conduct more research on a
cycloconverter that has six stages of the converter circuit, rather than the three stages mentioned before.
Furthermore, the sextuple cycloconverter, which can be used to practically drive high capacity
pumps or fans, will be developed by combining the “phase hopping” method and the soft-start method
mentioned in this paper.
Even More Complex…. When Mental Disorder Meets Addiction in Youth: Dual Pathology
Authors: Torales Julio , Castaldelli-Maia João M. , da Silva Antonio Geraldo , Campos Marcela W. , González-Urbieta Israel , Barrios Iván 
Published: November 2018

Background:The management of mental disorders in child and adolescent is challenging. In addition, when substance use disorders are associated with mental disorders, important complications are noted. Dual pathology and Substance-induced disorders should be distinguished in cases like this.Objective:To summarize the latest information on the epidemiology, etiology and management aspects of dual pathology in adolescents.Methods:PubMed, Web of Science, PsycINFO and SciELO databases were searched to perform a narrative review.Results:Dual pathology is the term used to designate the co-occurrence of an addictive disorder and at least one other mental health disorder, independently. To distinguish dual pathology from substance- induced disorders, the temporal association between the disorders in a longitudinal assessment should be emphasized. If the symptoms of the mental disorder appear prior to the substance use or after a long period of abstinence, a diagnosis of dual pathology should be considered. Patients with dual pathology present greater psychosocial issues, more medical problems, and worse prognosis than those with substance-induced disorders. The proposed etiological models agree that biological, psychological and social factors are shared in the development of these conditions.Conclusion:Healthcare systems should focus on creating policies that will allow early detection, preventive public health measures, and an integrated and coordinated care for these patients. Public health policies should create means to promote awareness and prevention of these pathologies since early initiation of treatment (pharmacological, psychotherapeutic, family therapy, education in schools, behavioral interventions and treatment of comorbidities) reduces the risks associated to substance use disorders and other negative consequences.
Nitrogen and Phosphorus Exchanges Across the Sediment–Water Interface in a Bay of Lake Chaohu
Authors: Liu Cheng , Gu Xiaozhi , Chen Kaining , Fan Chengxin , Zhang Lei , Huang Wei 
Published: November 2018

ABSTRACT: A year‐long field investigation was carried out in the most heavily polluted bay of Lake Chaohu to assess the temporal exchanges of ammonium nitrogen () and soluble reactive phosphorus (SRP) across the sediment–water interface (SWI) and to provide remediation advises. Results showed that the monthly average fluxes of and SRP were 31.38 and 6.98 mg m–2 d–1, respectively, both of which were higher than those in many other hyper‐eutrophic lakes around the world. The exchanges of and SRP were both closed related to the oxygen penetration. Low oxygen penetration depth and generally negative oxygen uptake rates provoked the dissolution of redox sensitive phosphorus and labile in the sediment and increased the fluxes. In addition, the generally higher fluxes during late spring to autumn should be noted during the reduction of internal loadings, when applicable techniques should be implemented accordingly to achieve better reduction effects.
Cofermenting Algal Biomass with Municipal Primary Solids to Enhance Carboxylate Production
Authors: Romenesko Taylor , Coats Erik R. 
Published: November 2018

ABSTRACT: As water resource recovery facilities (WRRFs) implement biological nutrient removal (BNR) processes to remove excess wastewater nutrients, carboxylic acid demands increase; resource recovery processes (e.g., struvite, polyhydroxyalkanoate production) also demand carboxylates. In this regard, interest in algae to achieve tertiary treatment creates a new intraWRRF fermentation substrate. Indeed, fermentation potential tests indicated that algal augmentation could prove beneficial; carboxylate concentrations increased 31 % over primary solids. However, unexpectedly, and disproving a key research hypothesis, algal augmentation in a fed‐batch fermenter decreased the production of carboxylic acids (26–34% at SRTs of 5–7 d); preliminary analyses suggest heterotrophic algae consumed carboxylates. Disproving a second research hypothesis, algal biomass did not significantly diversify carboxylate speciation. Finally, and unexpectedly, algal fermentation realized significant ammonia removal (39–96 % at SRTs of 5–7 d). Although decreased carboxylate yield is not desired, reduced ammonia load could potentially decrease WRRF energy demands and decrease carboxylic acid demands to achieve denitrification.
INFERIORITY DAN PERILAKU BULLYING DIMEDIASI OLEH DORONGAN AGRESI PADA REMAJA SEKOLAH MENENGAH PERTAMA
Authors: Istanti SIlvia Risa , Yuniardi Muhammad Salis 
Published: November 2018

Abstrak. Bullying menempati posisi pertama dibandingkan kasus lainnya di dunia pendidikan. Penelitian ini bertujuan untuk menguji pengaruh inferiority terhadap perilaku bullying dengan dorongan agresi sebagai variabel mediator. Partisipan penelitian berjumlah 150 pelaku bullying yang merupakan siswa SMP. Hasil analisis mediasi menggunakan ordinary leeast square regression dengan macro SPSS model 4 dari hayes menunjukkan bahwa inferiority mempengaruhi perilaku bullying remaja melalui perantara dorongan agresi. Remaja yang memiliki perasaan rendah diri, lemah, tidak mampu melakukan suatu hal akan cenderung memiliki dorongan agresi untuk melakukan kekerasan berupa perilaku bullying kepada orang.Kata Kunci: Dorongan Agresi, Perilaku Bullying, InferiorityAbstract. Bullying has been reported as the most frequent cases in education. This study aimed to examine the effect of inferiority on bullying behavior with aggression as a mediator variable. Participants were 150 bullying actors which were junior high school students. The mediation analysis using ordinary leeast square regression through macro SPSS model 4 from hayes showed that inferiority influenced bullying behavior of teenagers mediated by aggression encouragement. It means that teenagers who have inferiority, weakness feeling, feel unable to do anything will have the aggression encouragement to make a violence by doing bullying actions to others. Keywords: Aggression Encouragement, Bullying Behavior, Inferiority
PERAN CONTEXTUAL SUPPORT AND BARRIER TERHADAP CAREER INDECISION PADA MAHASISWA TINGKAT AKHIR
Authors: Pratiwi Dea Intan , Akmal Sari Zakiah 
Published: November 2018

Abstrak. Individu yang sudah menempuh pendidikan tinggi diharapkan telah memperoleh kompetensi untuk menentukan pilihan karier. Akan tetapi, tidak semua mahasiswa tingkat akhir mudah dalam menentukan pilihan karier, ada pula diantaranya yang mengalami kebingungan atau ketidakmampuan untuk menentukan pilihan karier atau yang disebut sebagai career indecision. Faktor penting yang secara langsung dapat mempengaruhi pilihan karier individu adalah faktor eksternal atau yang disebut sebagai contextual support and barrier. Penelitian ini dilakukan untuk mengetahui bagaimana peranan contextual support and barrier terhadap career indecision pada mahasiswa tingkat akhir di Indonesia. Penelitian ini merupakan penelitian asosiatif yang melibatkan 320 mahasiswa yang berkuliah di Indonesia, yang diperoleh dengan teknik sampel incidental sampling. Hasil penelitian menunjukkan bahwa contextual support and barrier berperan sebesar 10.9% terhadap career indecision yang dirasakan mahasiswa tingkat akhir. Contextual barrier berperan secara signifikan terhadap career indecision pada mahasiswa tingkat akhir. Kata kunci: Career Indecision, Contextual Support and Barrier, Mahasiswa Tingkat Akhir Abstract. Individuals who have higher education are expected to have acquired the competence to determine career choice. However, not every final-year college student are easy in determining career options, some of them are experiencing confusion or inability to choose their career or what is called career indecision. Important factors that can directly affect the individual's career choice is an external factor which are contextual support and barrier. This research was conducted to find out how the role of contextual support and barrier to career indecision among the final grade students in Indonesia. The method used in this study was associative research. Subjects in this study were 320 students who studying in Indonesia. The results showed that contextual support and barrier have a significant role toward the student's perceived career indecision by 10.9%. The contextual barrier has a significant role for the career indecision in the final grade students. Keywords : Career Indecision, Contextual Support And Barrier, Final-year Student
BIODEGRADASI DAN TOKSISITAS DETERJEN
Authors: Agustina Siti , Wuryanto Wuryanto , Suratmono Suratmono 
Published: November 2018

Deterjen merupakan bahan pembersih pakaian yang mengandung surfaktan dan bahan pengisi, yang banyak digunakan oleh manusia. Kriteria ekolabel menunjukkan bahwa biodegradasi deterjen adalah lebih besar dari 90% dan tingkat toksisitasnya terukur. Penelitian ini bertujuan untuk mengetahui biodegradibilitas dan toxicity deterjen. Hasil penelitian menunjukkan bahwa Bakteri pseudomonas dan bakteri bacillus dapat mendegradasi deterjen sebesar 96 - 97 %, dan toksisitas lingkungan yang diuji pada ikan mas menunjukkan LC 50 selama 96 jam adalah pada konsentrasi deterjen sebesar 3,5 ppm.
La2O3 takviyesinin ve mekanik alaşımlamanın basınçsız sinterlenmiş Al15Si2,5Cu0,5Mg kompozitlerinin mikroyapısal ve mekanik özelliklerine etkisi
Authors: TEKOĞLU Emre , AĞAOĞULLARI Duygu , GÖKÇE Hasan , ÖVEÇOĞLU M. Lütfi 
Published: November 2018

Bu çalışmanın amacı, alüminyum esaslı metal matris kompozit malzemelerin (AMMK) lantan oksit (La2O3) partikülleri ile takviyelendirilmek suretiyle toz metalurjisi yöntemleri kullanılarak sentezlenmesi ve bu kompozitlerin mikroyapısal/mekaniksel özellikler açısından karakterize edilmesidir. Deneysel çalışmalarda, elementel alüminyum (Al), silisyum (Si), bakır (Cu), magnezyum (Mg) ve La2O3 tozları, Al15Si2,5Cu0,5Mg-x La2O3 (x=ağ.% 0,5, 1, 2 ve 5) kompozisyonlarını oluşturacak şekilde harmanlanmış ve bu tozlar 4 sa süre boyunca birbirleri ile mekanik alaşımlanmıştır (MA). Takiben, harmanlanmış (0 sa MA) ve mekanik alaşımlanmış (4 sa MA) tozlar 450 MPa basınç altında tek eksenli pres kullanılarak soğuk preslenmiş ve preslenen bünyeler 570C’de 2 sa süre ile Ar gazı altında basınçsız olarak sinterlenmiştir. Harmanlanmış ve mekanik alaşımlanmış tozların ve sinterlenmiş kompozitlerin karakterizasyonları, X-ışınları difraksiyonu (XRD) ve taramalı elektron mikroskobu/enerji dağılımlı spektroskopi (SEM/EDS) teknikleri ile gerçekleştirilmiştir. Ayrıca, sinterlenmiş numunelerin rölatif yoğunlukları He gazı piknometresi ile saptanmıştır. Kompozitlere ait Vickers mikrosertlik değerleri ve aşınma kaybı hacimsel miktarları belirlenmiştir. Deneysel sonuçlara göre, kompozitlere ait mikrosertlik değerleri ve aşınma dirençleri, La2O3 miktarının artmasıyla artış göstermiştir. 4 sa alaşımlanmış ve sinterlenmiş Al15Si2,5Cu0,5Mg-ağ.% 5 La2O3 kompozit malzemenin, tüm kompozisyonlar içerisinde en yüksek sertliğe (172,24±38 HV) ve en düşük aşınma kaybına (0,115 mm3) sahip olduğu bulunmuştur.
Tıp Fakültesi Öğrencilerinin Çocukluk Yaş Grubunda Ateşle İlgili Bilgi ve Tutumlarının Değerlendirilmesi.
Authors: AKMAN Osman Sami , TORUN Akın , AYDIN Engin , BÜYÜKAVCI Mustafa 
Published: November 2018

Çocuklarda vücut sıcaklığı farklı
tekniklerle ve farklı yerlerden ölçülmekte ve bu da değerlendirmeyi
etkilemektedir. Biz bu çalışmada, tıp fakültesi öğrencilerinin çocuklardaki
ateş ölçüm yöntemleri ve bunların değerlendirilmesiyle ilgili bilgi ve tutumlarını
değerlendirmeyi amaçladık. Tıp Fakültesi’nde öğrenim gören 96 öğrenciye ikili
görüşmeyle 10 soruluk bir anket uygulandı. İlk 4 soru vücut sıcaklığı ölçüm
metotlarıyla, sonraki 5 soru ateş tanımı ile, son soru da ateşli çocuğa
yapılacak ilk girişimle ilgili idi. Öğrencilerin % 44,8’i (43 kişi) çocuklarda
vücut sıcaklığını ölçerken dijital termometre kullandığını belirtirken, 10 (% 10,4) öğrenci civalı, 10 öğrenci
infrared (alından) termometre kullandığını ifade etti. Hangi termometrenin vücut
ısısını daha doğru ölçtüğü sorusuna öğrencilerin 31’i dijital, 24’ü infrared ve
16’sı civalı termometre cevabını verirken 19’u bu konuda fikri olmadığını
söyledi. Öğrencilerin yarıya yakını (% 42,8) ateş demek için çocuklarda vücut
sıcaklığının üst sınırı olarak 37.5 °C’yi kabul etmekteydi. Yirmi kişi (%20,8)
37 °C, 15 kişi (%15,6) 38 °C ve 12 kişi de (%12,5) 36.5 °C’yi ateş sınırı
olarak belirtmişti. Katılanların %76’sı vücut sıcaklığının ölçüldüğü yere göre
değiştiğini, %18,8’i ise değişmediğini belirtmekteydi.Yüksek ateş saptanan
çocuğa ilk müdahale olarak öğrencilerin % 80’den fazlası giysileri çıkarma,
ılık suyla duş veya alın-koltuk altına pansuman önerirken, antipiretik ilaç
veren veya soğuk suyla duş öneren hemen hemen yoktu.Sonuç olarak, tıp fakültesi öğrencilerinin
önemli bir kısmının çocuk hastalarda vücut sıcaklığının ölçüm tekniği,
değerlendirilmesi ve yönetimi konusundaki bilgi ve tutumlarının yetersiz olduğu
gözlendi.
Secang (Caesalpinia Sappan) : Telaah Aktifitas Biologis Dan Potensi Pemanfaatannya
Authors: Kusuma Irawan W 
Published: November 2018

Plant resources serve abundant useful biological active substances. Secang, a local name of Caesalpinia sappan (Leguminosae), promise high possibility for a broad-ranging purposes due to its biological activities. In traditional manner, the wood of secang is used for coloring agent for beverages, foods and cosmetics. Several phytochemicals were isolated from the secang extract, including brazilin, brezilein, protosappanin, 4-0-methy/ sappanol, caesalpin, kampesterol and b-sitosterol. Secang extract and the compounds thereformhave been reported to possess a huge variety of biological activities such asantioxidant, antibacterial, antifungal, anticancer, natural contraceptive and xanthine oxidase (XO) inhibitor.The biological activities of the extracts andph vtochemicals ftrom secang may give scientific basis for their application in agricultural, food processing, medical and other industries.
Market analysis to the Steel industry: evidence from Egypt
Authors: Salman Abdou Doaa Mohamed , Tarek Hossam , Tarek Kareem 
Published: November 2018

This case study is guidance for the market forces in one of the important industries. This study is prepared to analyze the market forces affecting the flat steel industry during the period from 2013 till 2017 in Egypt. Â The steel market in Egypt is a very wide market with many companies and a wide variety of products. The study will provide insight on the supply, demand and elasticity of Flat steel produced by Al-Ezz Dekheila Steel Company which is one of the biggest producers of flat steel in the Middle East. Finally conclusion.
Health assistance infection in a neonatal intensive therapy unit / Infecção relacionada à assistência a saúde em unidade de terapia intensiva / Infección relacionada a la asistencia de la salud en unidad de terapia intensiva neonatal
Authors: Pimentel Camila Santana , Nunes Daniela De Carvalho , Bittencourt Isaiane Santos , Da Silva Rudval Sousa , Dos Santos Isis Cristiane Marques , Pereira Rosany Claudia Dantas 
Published: November 2018

Objetivo: descrever as principais características das infecções hospitalares em Unidade de Terapia Intensiva Neonatal. Metodologia: Estudo descritivo de revisão de literatura, que utilizou a busca eletrônica, nas bases de dados científicas e análise e interpretação dos dados com base na Análise de Conteúdo de Bardin. Resultado: Delimitaram-se três categorias: Tipos de transmissão das Infecções Relacionadas à Assistência à Saúde em neonatos; Principais microrganismos presentes nas infecções em neonatos; e Recomendações para controle e prevenção de infecções em neonatos. Verificou-se que a transmissão destas infecções dividem-se em transplacentárias; precoce, de provável origem materna; e tardias, de origem hospitalar. Dentre os microrganismos mais relatados na literatura estão o Staphylococcus coagulase negativa, Staphylococcus aureus, Klebsiela pneumoniae, Candida sp e Pseudomonas aeruginosa. E as principais formas de controle e prevenção envolvem a lavagem, o uso controlado de antimicrobianos e a orientação aos pais e responsáveis quanto ao manuseio do neonato. Conclusões: Tais constatações podem contribuir para a ampliação do conhecimento dos profissionais que atuam nas Unidades de Terapias Intensivas Neonatais, possibilitando uma assistência de qualidade aos recém-nascidos.Palavras chaves: Assistência à saúde. Infecção. Infecção Hospitalar. Unidade de Terapia Intensiva Neonatal.
Decision Support System to Determine the Number of Production Tofu using the Fuzzy Sugeno Method (Case Study: Home Industries Tofu in Seyegan District)
Authors: Indrianingsih Yuliani 
Published: November 2018

The production process is a way to increase the usefulness of an item and service using existing production factors. The decision making process to determine the amount of production, especially in the business world contains risks. It needs to be supported by careful calculations so that the risk of loss can be avoided. Industri associations tofu "Waluyo" in Seyegan who still determines the amount of production manually. From the above problems a Decision Support System (DSS) was made using Sugeno's fuzzy method. In this DSS there are three variables modeled, namely, inventory variables, demand variables and production variables. The demand variable consists of two fuzzy sets, the inventory variable consists of two fuzzy sets and 4 rules which are the production rules used by Industry associations tofu "Waluyo" in determining the amount of production. Based on the acuracy test using the MAPE (Mean Absolute Percentage Error) method obtained a value of 5,3069% or below the error rate of 10%. So this system can be applied in determining the amount of tofu production in the tofu industri community in Seyegan.
THE DEVELOPING OF TEMATIK TEACHING MEDIA MAGIC PUZZLE THEME BERBAGI PEKERJAAN IN FOURTH GRADE OF PRIMARY SCHOOL
Authors: Saraswati Dewi , Wijayanti Arfilia 
Published: November 2018

Background of this research is that tematik teaching media are limited. It is influence the students interesting in learning process are not optimal. Statements of the problem of this research is how the development and analyze validation and practicability of tematik teaching media Magic Puzzle in teaching learning process theme kind of occupations in fourth grade in Primary School. Kind of this research is about Reasearch and Development with the procedure of ADDIE research. Population of this research is all students of Primary School 1 Nyamok are 30 students and all students of Primary School 2 Sumurjomblangbogo are 26 students in academic years of 2017/2018. This development results is tematik teaching media Magic Puzzle in theme of kind of occupation. The result of this study is validation from media expert and material expert with the ideal number of 90% and 80% and the perceptive of teacher and students with Magic Puzzle media with the ideal number of 83% and 97%.