bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporation of Cornus mas L. in Soybean Oil: Evaluation of Phytochemical and Antioxidant Activity
Authors: Shariatifar Nabi , Amanlou Massoud , Rahimnia Ramin , Mahernia Shabnam , Khaneghah Amin M. 
Published: December 2018

Background:
The active compounds of Cornus mas L. were extracted by the aid of water
and ethanol and were incorporated into soybean oil samples. Afterward, their antioxidant activities
were examined.

Methods:
The 1, 1 diphenyl-2- picrylhydrazyl (DPPH) and beta-carotene methods were approached
in order to assess the antioxidant capacity. Different concentrations of extracts prepared (0,200, 400
and 800 mg/lit) and β hydroxyl toluene (BHT, 100 mg/lit) were added into soybean oil, and the resulted
mixtures were incubated for 35 days at 65°C. Peroxide values (PVs) and thiobarbituric acidreactive
substances (TBARs) levels were measured each week during the incubation. The collected
data from each incubation was analyzed using ANOVA test.

Results:
Results demonstrated that corresponded values for β-carotene-linoleic acid and DPPH assay
of the Cornus mas L. extracted by ethanol and water were lower than synthetic antioxidant and BHT.

Conclusion:
PVs and TBARs levels of soybean oil during the incubation time was decreased by the
incorporation of extracts (water and ethanol) of Cornus mas L. while compared to the control.
De-Novo Ligand Design against Mutated Huntington Gene by Ligand-based Pharmacophore Modeling Approach
Authors: Munir Anum , Malik Shaukat I. , Malik Khalid A. 
Published: December 2018

Background:
Huntington's disease is characterized by three side effects, including motor
disturbances, psychiatric elements, and intellectual weakness. The onset for HD has nonlinear converse
associations with the number of repeat sequences of the polyglutamine mutations, so that younger patients
have a tendency for longer repeats length. This HD variation is because of the development of a
polyglutamine (CAG) repeats in the exon 1 of the Huntingtin protein.

Methods:
In the present study, a few derivatives utilized as a part of the treatment of HD, are used to
create the pharmacophore model and based on the features of the pharmacophore model; an attempt is
made to design the de-novo drug for the HD protein. HD protein structure was built and docked with
the novel ligand, based on shared feature pharmacophore model, through a ligand-based pharmacophore
modeling approach.

Results:
The novel ligand contains 1 HBAs, 2 HBDs, and 2 aromatic rings. It fulfills all the properties of certain
drug-likeness rules, non-toxic in nature. In the docked complex, the common interactive amino acids
identified are SER 1035, ALA 1062, MET 1068, LEU 1031, and THR 1036, which confirmed the validity
and stability of a ligand molecule to be used as a drug in the treatment of Huntington’s disease.

Conclusion:
A novel ligand can be used in clinical trials as a drug molecule against the mutations of
HD gene and in laboratory procedures for efficacy analysis.
Ендотеліальна функція судин і реологічні властивості крові при опіковій травмі
Authors: Samoilenko G.Ye. , Kolesnik A.I. , Syniachenko O.V. , Andreiev O.V. 
Published: December 2018

Актуальність. Тяжкість опікової травми відображає ступінь судинних ушкоджень із паравазальними змінами, розвитком порушень функції ендотеліоцитів судин й еритроцитарно-тромбоцитарної ланки реологічних властивостей крові. Мета дослідження: вивчити клініко-патогенетичну значущість ендотеліальної дисфункції судин та реологічних властивостей сироватки крові при опіковій травмі. Матеріали та методи. Під наглядом перебували 117 потерпілих від опікової травми, серед яких було 83 % чоловіків і 17 % жінок віком від 14 до 79 років (в середньому — 44 роки). Термін обстеження після отримання опікової травми становив до 7 діб (в середньому — 2 доби). Показники ендотеліальної функції судин досліджували імуноферментним методом, а реологію крові — фізико-хімічним методом форми вісесиметричних крапель. Результати. У хворих з опіковою травмою показники судинного ендотеліального чинника зростання (VEGF) становили 465,0 ± 10,9 пг/мл, ендотеліну-1 (ET1) — 5,0 ± 0,2 пг/мл, тромбоксану A2 (TxA2) — 12,0 ± 0,9 нг/мл, простацикліну (PgI2) — 44,0 ± 4,2 нг/мл, поверхневої в’язкості (SV) — 14,00 ± 0,23 мН/м, пружності — 43,0 ± 0,6 мН/м, модуля в’язкоеластичності — 24,0 ± 0,8 мН/м, сурфактантного індексу — 48,0 ± 0,8 в.о. Порівняно з конт-рольною групою умовно здорових осіб опіки супроводжуються підвищенням вмісту VEGF у 5,2 раза, ET1 — на 28 %, TxA2 — на 69 % при зменшенні рівня PgI2 на 35 % і SV на 12 %, що спостерігається відповідно в 98, 54, 27, 32 і 42 % випадків, а показники корелюють між собою (SV ↔ ET1, SV ↔ PgI2) і лабораторними критеріями хвороби, залежать від тяжкості перебігу патологічного процесу (параметри ступеня респіраторного опіку, інтегральної тяжкості травми й шоку), впливають на виживаність потерпілих, а рівень VEGF має прогностичну значущість. Висновки. Порушення ендотеліальної функції судин і реологічних властивостей сироватки крові беруть участь у патогенетичних побудовах опікової травми.
Гипоксически-ишемическая энцефалопатия у доношенных новорожденных: факторы риска и их влияние на течение острого периода
Authors: Surkov D.M. 
Published: December 2018

В статье рассмотрены антенатальные и интранатальные факторы риска развития тяжелой гипоксически-ишемической энцефалопатии (ГИЭ) и их влияние на течение острого периода ГИЭ у доношенных новорожденных. Проанализированы данные 205 доношенных новорожденных, которые находились на лечении в отделении анестезиологии и интенсивной терапии новорожденных КУ «Днепропетровская областная детская клиническая больница» ДОС» в период 2009–2016 гг. Исследованы такие факторы риска, как пол, гестационный возраст, масса тела при рождении, первые или повторные роды, введение окситоцина, отслойка плаценты, кесарево сечение, дистресс плода, обвитие пуповины, наличие мекония в околоплодных водах, оценка по Апгар на 1, 5 и 20-й минуте после рождения, проведение неонатальной реанимации при рождении, а также в течение какого времени после родов дети поступали в отделение интенсивной терапии для проведения специализированного лечения (0–6 часов, 6–24 часа или 24–72 часа). В качестве конечных показателей использованы летальность, продолжительность проведения искусственной вентиляции легких и вообще респираторной поддержки (включая неинвазивную), продолжительность нахождения в отделении интенсивной терапии и в целом в больнице до выписки на амбулаторное лечение, развитие тяжелого осложнения в виде церебральной лейкомаляции.
Sinergitas Aktivitas Antibakteri dari Kelopak Bunga Rosella dan Kitosan Terhadap Staphylococcus aureus
Authors: Haeriah Haeriah , Djide Natsir , Alam Gemini , Sartini Sartini 
Published: December 2018

Currently, the antibacterial research is increasingly promoted primarily from natural materials, due to the increasing number of pathogenic bacteria that have been resistant to existing antibiotics. One of the pathogenic bacteria that has been much resistant to antibiotics is Staphylococcus aureus. Rosella calyx (Hibiscus sabdariffa L.) and chitosan are known to have antibacterial activity. The aim of this study to find out the antibacterial synergy of the roselle calyx extract and chitosan against. S.aureus ATCC 33592. Rosella calyx was extracted by maceration using 80 % ethanol, while chitosan is obtained from deasetilation chitin of shrimp husk. Test antibacterial synergism using checkboard assay method by calculating the minimum inhibitory concentration (MIC) using microdilution assay. The results showed minimum inhibitory concentration (MIC) value of roselle calyx extract and chitosan were 1250 ppm and 50 ppm, respectively. MIC value of rosella calyx extract in the presence of chitosan was 625 ppm, while the value of MIC chitosan in the presence of rosella calyx extract was < 0.19 ppm. Fractional Inhibition Concentration Index (FICI) was < 0.5 which concluded that the combination of roselle calyx extract with chitosan has a synergistic antibacterial effect on S.aureus ATCC 33592.
Mikroenkapsulasi Antosianin Kulit Buah Kakao (Theobroma cacao L.) Dengan Metode Koaservasi Kompleks
Authors: Lubis Siska Syahfitri , Sulastri Evi , Zubair Muhammad Sulaiman 
Published: December 2018

Anthocyanin is a class of antioxidants that are widely found in the skin of cocoa fruit (Theobroma cacao L.). Anthocyanin degradation occurs not only during the extraction process from plant tissues but also during the storage process. The microencapsulation process can protect the active substance from environmental influences or improve the stability of the preparation. This study aims to characterize anthocyanin microcapsules from cocoa (Theobroma cacao L.) fruit peel using a complex coacervation method, therefore, it can provide economic value added from this plant. Anthocyanin microencapsulation was formulated using a coating of gelatin: arabic gom with different concentrations of 1:1, 3:2, and 2:1. Microcapsule characterization was organoleptic and morphological test, particle size distribution, moisture content test, absorption efficiency, recovery test, antioxidant activity of the preparation, and FTIR analysis. The results showed that extract yield was 39.82%, optimum microcapsule characterization was obtained from 1: 1 concentration with 36.65% recovery test, 80.40% absorption efficiency, and antioxidant activity with IC50 of 20.52 ppm.
Assessment of passengers 'satisfaction from the organization of MPK Kraków public transport services
Authors: Brożyna Ewa 
Published: December 2018

This article raises a subject of organization quality of public transport services. The author presented in it the results of the second part of the original research conducted among passengers of Miejskie Przedsiębiorstwo Komunikacyjne S.A. in Krakow, which showed the level of passenger satisfaction from the three aspects of the transport organization of MPK Kraków, which are: accessibility of the communication network (availability of connections and deployment of stops), information system (information channels for passengers and the level of culture and competence in servicing passengers) and issues related to tickets (operation of ticket machines, operation of the Krakowska Karta Miejska, ticket control). The aim of the research was to acquire knowledge about the passengers' perception of the quality in organization of MPK Krakow services and to develop on this basis practical tips and suggestions regarding the directions of actions that can be taken to improve the organization of these services.
Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.
Authors: Ramadan Abdul Aziz , Bakdash Marwa 
Published: December 2018

A simple, direct and cost-effective spectrophotometric method for determination of cefuroxime axetil (CRXA) in pure and tablet dosage forms was applied. This method is based on formation of ion-pair complex ([CRXA]:[BTB]) between CRXA and bromothymol blue (BTB) in chloroform. Beer’s law in the optimum experimental conditions using [CRXA]:[BTB] complex is valid within a concentration range of 2.00-50.00 ?M (1.021–25.524 ?g.mL-1). The developed method is applied for the determination of CRXA in pure and its commercial tablets without any interference from excipients with average assay of 96.8 to 101.6% and the results are in good agreement with those obtained by the HPLC reference method. Associated drugs (sulbactam and linesolid) with cefuroxime axetil are considered to be interfere, while metronidazole can be considered as non-interfere.
Gratitude to All Who Contributed to JOSPT in 2018
Authors: Simoneau Guy G. 
Published: December 2018

As the door closes on 2018, Interim Editor-in-Chief Dr. Guy Simoneau expresses his gratitude and recognizes the many colleagues who contributed to the editorial process of JOSPT over the past 12 months. It is through their commitment, talent, and knowledge that JOSPT can continue to publish high-quality content that leads to more effective clinical practice and improved patient outcomes. J Orthop Sports Phys Ther 2018;48(12):908–910. doi:10.2519/jospt.2018.0108
Is There a Postworkout Anabolic Window of Opportunity for Nutrient Consumption? Clearing up Controversies
Authors: Schoenfeld Brad Jon , Aragon Alan Albert 
Published: December 2018

Nutrient timing is a popular strategy for enhancing muscular adaptations and athletic performance. From the standpoint of muscle hypertrophy, the concept of a “postworkout anabolic window of opportunity” has been proposed, whereby a limited time exists after training to optimize accretion of muscle proteins. Some researchers have gone so far as to claim that the timing of nutritional consumption is even more critical to muscle development than the absolute daily consumption of nutrients. Thus, the purpose of this paper is to review the current literature as to the relevance of the anabolic window of opportunity, and draw evidence-based conclusions for application into practice. J Orthop Sports Phys Ther 2018;48(12):911–914. doi:10.2519/jospt.2018.0615
The Association Between Passing Return-to-Sport Criteria and Second Anterior Cruciate Ligament Injury Risk: A Systematic Review With Meta-analysis
Authors: Losciale Justin M. , Zdeb Rachael M. , Ledbetter Leila , Reiman Michael P. , Sell Timothy C. 
Published: December 2018

Background There is no consensus on the components of return-to-sport (RTS) testing following anterior cruciate ligament (ACL) reconstruction or whether passing RTS criteria can reduce a patient's risk of reinjury. Objectives To determine whether impartial, criteria-based RTS decisions are associated with less risk of a second ACL injury (either graft failure or contralateral ACL injury). Methods In this systematic review with meta-analysis, the authors conducted an electronic literature search in PubMed/MEDLINE, Embase, CINAHL, SPORTDiscus, and ProQuest Dissertations and Theses Global using database-specific vocabulary related to ACL reconstruction and return to sport. Individual study quality was assessed using the modified Downs and Black checklist, and overall quality of evidence was determined with the Grading of Recommendations Assessment, Development and Evaluation scale. Pooled risk difference (passed versus failed RTS criteria), injury incidence proportion, and the diagnostic accuracy of each RTS criterion were calculated. Results Four studies met the selection criteria. Overall, 42.7% (95% confidence interval [CI]: 18%, 69%) of patients passed RTS criteria, and 14.4% (95% CI: 8%, 21%) of those who passed experienced a second ACL injury (graft rupture or contralateral ACL injury). There was a nonsignificant 3% reduced risk of a second ACL injury after passing RTS criteria (risk difference, −3%; 95% CI: −16%, 10%; I2 = 74%, P = .610). The evidence rating of the Grading of Recommendations Assessment, Development and Evaluation scale was “very low quality,” due to imprecision and heterogeneity of the pooled risk difference estimate. Conclusion Passing RTS criteria did not show a statistically significant association with risk of a second ACL injury. The quality-of-evidence rating prevents a definitive conclusion on this question and indicates an opportunity for future research. Level of Evidence Prognosis, Level 2a-. J Orthop Sports Phys Ther 2019;49(2):43–54. Epub 30 Nov 2018. doi:10.2519/jospt.2019.8190
The Effects of Needling Therapies on Muscle Force Production: A Systematic Review and Meta-analysis
Authors: Mansfield Cody J. , Vanetten Lucas , Willy Richard , di Stasi Stephanie , Magnussen Robert , Briggs Matthew 
Published: December 2018

Background Needling has been shown to decrease pain in the short term; however, its effects on muscle force production are unclear. Objective To evaluate the evidence regarding the comparative effects of needling on muscle force production. Methods In this systematic review, an electronic search was performed using key words related to needling. Methodological quality of articles was appraised and effect sizes were calculated. The strength of evidence was determined, and meta-analysis was performed when similar methods were used in studies for similar conditions. Results Twenty-one studies were included in this review, of which 9 were deemed to be of high quality (greater than 6/10 on the Physiotherapy Evidence Database [PEDro] scale), 11 of fair quality (5 to 6/10), and 1 of poor quality (less than 5/10). Three meta-analyses were performed. There was moderate strength of evidence and medium effect sizes for needling therapy to enhance force production in those with neck pain, and very low strength of evidence of no effect for individuals with nonspecific and postoperative shoulder pain and those with lateral epicondylalgia. Other studies not included in the 3 meta-analyses demonstrated no significant effect of needling on force production. These studies included individuals with carpal tunnel syndrome, knee osteoarthritis, ankle sprains, knee arthroscopy, or delayed-onset muscle soreness. Conclusion The majority of studies suggest no effect of dry needling on force production. High-quality studies with adequate power that control for the placebo effect and follow accepted reporting standards could make valuable contributions to the literature. This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO, CRD42017080318). Level of Evidence Therapy, level 1a. J Orthop Sports Phys Ther 2019;49(3):154–170. Epub 30 Nov 2018. doi:10.2519/jospt.2019.8270
Influence of Aging on Lower Extremity Sagittal Plane Variability During 5 Essential Subphases of Stance in Male Recreational Runners
Authors: Morgan Jacqueline , Kwon Yong Ung , Williams D.S. Blaise 
Published: December 2018

Background Interjoint coordination variability is a measure of the ability of the human system to regulate multiple movement strategies. Normal aging may reduce variability, resulting in a less adaptive system. Additionally, when older runners are asked to run at speeds greater than preferred, this added constraint may place older runners at greater risk for injury. Objectives To examine the influence of normal aging on coordination variability across 5 distinct subphases of stance in runners during preferred and fixed speeds. Methods Twelve older (60 years of age or older) and 12 younger (30 years of age or younger) male recreational runners volunteered for this cross-sectional study. Three-dimensional gait analyses were collected at preferred and fixed speeds. Stance phase was divided into 5 subphases: (SP1) loading response, (SP2) peak braking, (SP3) peak compression, (SP4) midstance, and (SP5) peak propulsion. Continuous relative phase variability for sagittal plane joint pairs—hip-knee, knee-ankle, and hip-ankle—was calculated. Repeated-measures linear mixed models were employed to compare variability for each joint pair. Results An age-by-stance subphase interaction was found for knee-ankle (P<.01) and hip-ankle (P<.01) pairs, while main effects for age and stance subphase were found for the hip-knee pair (P<.05). Specifically, loading response and peak braking variability were lower in older runners and greater across stance for knee-ankle and hip-ankle pairs, while midstance was lowest in the hip-knee pair for older and younger runners. No effects for running pace were found. Conclusion Less adaptive movement strategies seen in older runners may partially contribute to the increased eccentric stresses during periods of high load. J Orthop Sports Phys Ther 2019;49(3):171–179. Epub 30 Nov 2018. doi:10.2519/jospt.2019.8419
Accuracy of Clinical and Imaging Tests for the Diagnosis of Hip Dysplasia and Instability: A Systematic Review
Authors: Reiman Michael P. , Décary Simon , Mathew Benoy , Reiman Carly K. 
Published: December 2018

Background Evidence concerning the accurate clinical or imaging methods to diagnose hip instability or hip dysplasia is currently scarce. Objective To summarize the diagnostic accuracy of clinical and imaging tests for the diagnosis of hip dysplasia and instability. Methods A computer-assisted literature search of the MEDLINE, CINAHL, and Embase databases, using key words related to diagnostic accuracy of the hip joint, was conducted on March 6, 2018. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the searching and reporting phases of the study. Quality assessment of bias and applicability was conducted using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Diagnostic accuracy, including sensitivity, specificity, likelihood ratio, and 95% confidence interval, was summarized. Results Out of 3109 citations, 7 articles were included. Two studies reported on 5 clinical tests for hip instability and 5 studies reported on 5 radiographic measures for hip dysplasia. Only 1 study was not of low methodological quality. The prone instability test moderately improved positive posttest probability by 38% to diagnose hip instability. The Shenton line moderately to highly improved posttest probability by 41% to 60% to diagnose hip dysplasia. Conclusion This systematic review summarizes the diagnostic accuracy of various clinical tests and radiographic measures for hip instability and hip dysplasia. Further high-quality studies are necessary to examine the diagnostic accuracy of the clinical examination and radiography to assist in ruling in or ruling out the diagnoses of hip dysplasia and instability. Consensus is required to standardize the definitions of these diagnoses and their reference standards. The study was registered with the International Prospective Register of Systematic Reviews (CRD42018089019). Level of Evidence Diagnosis, level 3b. J Orthop Sports Phys Ther 2019;49(2):87–97. Epub 30 Nov 2018. doi:10.2519/jospt.2019.8476
RETRACTED: Model Latihan Passing Bawah Bola Voli Pada Siswa Sekolah Menengah Pertama
Authors: Abrasyi Rendy , Hernawan Hernawan , Sujiono Bambang , Dupri Dupri 
Published: December 2018

This article has been withdrawn at the request of the Chief Editor. The reason for the withdrawal is because this article was also published in the Prosiding Seminar dan Lokakarya Fakultas Ilmu Keolahragaan Universitas Negeri Jakarta.
Link: (http://journal.unj.ac.id/unj/index.php/prosidingfik/article/view/10714).
The condition for submitting a work for publication is that the author explicitly states that all of his works are original and have not appeared in publications elsewhere. We apologize to journal readers that this was not detected during the delivery process.
Внутрилимфатическая терапия в онкологии. История, опыт и перспективы применения в Республиканском онкологическом центре им. проф. Г.В. Бондар
Authors: Седаков И. Е. , Комендант В. В. , Аль Баргути Айман Ахед , Делегойдина А. В. , Исиков А. П. 
Published: December 2018

В статье на основании обзора данных литературы и собственных разработок Республиканского онкологического центра им. проф. Г. В. Бондаря представлено обоснование методики внутрилимфатического введения лекарственных препаратов, приведены экспериментальные данные разных авторов, доказывающие большую эффективность эндолимфатического введения как антибиотиков, так и цитостатиков, сформулированы основные преимущества данного метода введения препаратов. Показана эффективность лечения опухолей различных локализаций в комплексной терапии с использованием внутрилимфатического введения препаратов. Указаны основные научные направления, исследования, продолжающиеся в Республиканском онкологическом центре с использованием внутрилимфатической химиотерапии, позволяющие индивидуализировать подход к лечению опухолей различных локализаций как в неоадъювантном, адъювантном, так и в паллиативном режиме.
Some General Properties of Bi-shadowing Property
Authors: Ajam Mohammed Hussein Obaid , Talb Iftichar Mudhar 
Published: December 2018

We concentrate on bi-shadowing property, it has important properties and applications in mathematics. In this paper some general properties of this concept are proved. Let be a metric space be maps have bi-shadowing property. We show the maps and have bi-shadowing property.
Let be maps on a metric space have bi-shadowing property. We show the maps and have bi-shadowing property.