bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐year clinical outcome of biodegradable polymer sirolimus‐eluting stent in patients presenting with acute myocardial infarction: Insight from the ULISSE registry
Authors: Moscarella Elisabetta , Ielasi Alfonso , Beneduce Alessandro , Ferrante Giuseppe , Pivato Carlo Andrea , Chiarito Mauro , Cappelletti Alberto , Perfetti Giulia , Magni Valeria , Prati Eugenio , Falcone Stefania , Pierri Adele , De Martini Stefano , Montorfano Matteo , Parisi Rosario , Rutigliano David , Locuratolo Nicola , Anzuini Angelo , Calabrò Paolo , Tespili Maurizio , Margonato Alberto , Benassi Alberto , Briguori Carlo , Fabbiocchi Franco , Reimers Bernhard , Bartorelli Antonio , Colombo Antonio , Godino Cosmo 
Published: May 2019

AbstractBackgroundThe ULISSE registry has demonstrated the real‐world performance of the Ultimaster biodegradable polymer sirolimus‐eluting stent (BP‐SES) in a large cohort of patients undergoing percutaneous coronary intervention, including a large proportion of patients presenting with acute myocardial infarction (AMI).MethodsWe performed a subgroup analysis of the ULISSE registry in AMI patients and compared the outcomes of this vulnerable cohort with that of patients presenting without AMI (non‐AMI). The primary end point was the incidence of 1‐year target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TV‐MI), and clinically indicated target lesion revascularization (TLR).ResultsOf 1,660 patients included in the ULISSE registry, 381(23%) presented with AMI, 207(54.3%) non‐ST elevation myocardial infarction, and 174(45.7%) ST‐elevation myocardial infarction. Compared with non‐AMI patients, those with AMI were more frequently female and smokers, with lower left ventricular ejection fraction (LVEF) and chronic kidney disease requiring dialysis. At 1 year, TLF rate was significantly higher in AMI than non‐AMI patients (7.9 vs. 4.1%; HR 1.98, CI 95% 1.22–3.23; p = .005) driven by higher rate of cardiac death (4.0 vs. 1.1%; HR 3.59, CI 95% 1.64–7.88; p = .01) and TV‐MI (2.8 vs 0.9%; HR 2.99,CI 95% 1.22–7.37; p = .01), without differences in TLR rate (4.3 vs. 2.9%,HR 0.66, CI95% 0.35–1.25; p = .2). At multivariate Cox regression analysis, eGFR <40 mL/min (HR: 2.868) and LVEF <40% (HR: 2.394) were the only independent predictors of TLF.ConclusionsIn AMI patients, Ultimaster BP‐SES implantation was associated with higher rate of TLF and definite stent thrombosis compared with non‐AMI patients. The high incidence of adverse events was mainly driven by the unfavorable baseline risk profile.
Influence of particle size on flour and baking properties of yellow pea, navy bean, and red lentil flours
Authors: Bourré Lindsay , Frohlich Peter , Young Gina , Borsuk Yulia , Sopiwnyk Elaine , Sarkar Ashok , Nickerson Michael T. , Ai Yongfeng , Dyck Adam , Malcolmson Linda 
Published: May 2019

AbstractBackground and objectivesPulse flours are produced by dry grinding pulses. Currently, no standards exist for the particle size of pulse flours. The objective of this study was to investigate how particle size affected the flour and bread‐baking properties of commercially milled pulse flours and those produced using a Ferkar mill.FindingsFiner pulse flours tended to have greater starch damage, lower water absorption capacity (WAC), and higher peak and final viscosities. Navy bean flour had a larger particle size distribution, lower starch damage, greater WAC, and lower peak and final viscosities due to presence of hull. Red lentil flour had a larger particle size distribution and higher starch damage than yellow pea flour. Bread made with finer pulse flours had better bread scores and a tighter, less open crumb structure. Bread volume was not affected by flour particle size, nor were the sensory properties of the bread in most cases.ConclusionsParticle size affected flour and bread‐baking properties of pulse flours indicating that particle size should be considered when formulating pulse‐based breads. Flours milled from whole pulses will have larger particle size distributions due to the presence of hull. Seed hardness will affect the grinding properties of pulses which will affect particle size and starch damage.Significance and noveltyStandardization of particle size for pulse flours would allow for consistency when sourcing flours from different suppliers. However, given that different particle size distributions may be better suited to certain applications than others, it may be more useful if suppliers specify the particle size similar to what is done with oat ingredients.
Underpotential Photoelectrooxidation of Water by SnS2−Laccase Co‐catalysts on Nanostructured Electrodes with Only Visible‐Light Irradiation
Authors: Jarne Carmen , Paul Logan , Conesa José Carlos , Shleev Sergey , De Lacey Antonio L. , Pita Marcos 
Published: May 2019

AbstractMore sustainable ways to produce and store energy are urgently needed to reduce our dependence on fossil fuels, which are the principal drivers of global warming and pollution. Hydrogen may become the energy vector needed for this purpose if its production through water splitting can become competitive against steam methane reforming. Even after decades of research, the proposed strategies for water splitting are not efficient enough to overcome the high overpotential of the water oxidation reaction. In a quest for new approaches to this problem, recent studies have attempted to combine inorganic catalysts with biocatalysts, aiming to open new possibilities towards a definitive solution. In the present work we have tested a chalcogenide semiconductor, SnS2, characterized by a deep valence band and a visible‐light band gap of approximately 2.2 eV (λ=550 nm). Preparation of a fluorine‐doped tin oxide electrode modified with SnS2 and laccase allowed water oxidation at a lower overpotential, taking better advantage of light energy. Additionally, indium tin oxide nanoparticles were added to increase the contact area between SnS2 and the electrode surface and thereby improve charge separation for photobioelectrocatalytic water oxidation. We tested the nanostructured anode electrodes under different applied potentials and irradiance intensities from a solar simulator to find the optimal photonic and faradaic efficiencies.
On shifting consumers from high‐interest to low‐interest debt
Authors: Greenberg Adam Eric , Hershfield Hal E. 
Published: May 2019

AbstractIn the United States, many consumers are increasingly accumulating debt, much of which is harmful and expensive. Prior research has devoted a great deal of attention to understanding why consumers generally get into debt and the strategies they can use to repay existing debts. While this work has furthered the agenda of helping consumers reduce or eliminate their overall debt balances, it has failed to emphasize the fact that for many consumers, debt may be unavoidable. This article aims to promote research that addresses not only overall debt reduction but also the need for consumers to shift from more to less costly types of debt. By shedding light on the psychological reasons why consumers may naturally gravitate toward more costly forms of debt when less costly ones may be available, we offer a novel perspective on why consumers get into and stay in debt longer than they should. This new angle has the potential to spur on further research into the ways consumers can use debt more effectively and less expensively in service of the overarching goal of debt reduction.
Regiochemistry Control by Bipyridine Substituents in the Deprotonation of ReI and MoIIN‐Alkylimidazole Complexes
Authors: Espinal‐Viguri Maialen , Fombona Sergio , Álvarez Daniel , Díaz Jesús , Menéndez M. Isabel , López Ramón , Pérez Julio , Riera Lucía 
Published: May 2019

AbstractCompounds containing N‐alkylimidazoles (N‐RIm) and 4,4′‐disubstituted 2,2′‐bipyridines (4,4′‐R′2bipy) coordinated to cationic {Mo(η3‐C4H7)(CO)2} and {Re(CO)3} fragments undergo deprotonation of the C2‐H group of the N‐RIm ligands in their reactions with KN(SiMe3)2. The resulting internal nucleophile adds either to one pyridyl ring, which becomes dearomatized and can undergo ring opening in the subsequent reaction with excess MeOTf, or to the metal center, yielding imidazol‐2‐yl complexes, which in turn add HOTf or MeOTf, affording N‐heterocyclic carbene complexes. Which pathway is followed is dictated by the metal and the nature of the imidazole (R) and bipyridine (R′) substituents. For ReI compounds, addition to pyridine is found with R′=tBu and OMe, whereas for R=Me and R′=NMe2, imidazolyl formation is preferred. Coordination of 4,7‐Cl2‐1,10‐phenanthroline to MoII favors C−C coupling, in contrast to the analogous parent bipy or phenanthroline complexes, for which formation of the imidazol‐2‐yl complexes had been found. DFT calculations showed the theoretically expected products in each case, and following their predictions new types of products were obtained experimentally.
B2N2‐Embedded Polycyclic Aromatic Hydrocarbons with Furan and Thiophene Derivatives Functionalized in Crossed Directions
Authors: Chen Yijing , Chen Weinan , Qiao Yanjun , Zhou Gang 
Published: May 2019

AbstractA series of polycyclic aromatic hydrocarbons (PAHs), consisting of two pairs of BN units, have been designed and their synthesis has been achieved by electrophilic C−H borylation. Two conjugation extension directions can be found in these B2N2‐embedded PAHs. The B2N2‐containing backbone with shorter effective conjugation length is isoelectronic with diaryl‐fused anthracene, whereas the second derivative, with longer effective conjugation length, is isoelectronic with bis(trans‐arylvinyl)benzene. By incorporating different aryl groups, i.e., furyl, thienyl, benzo[b]furyl, and benzo[b]thienyl groups, into the two crossed directions of the B2N2‐embedded PAHs, their electronic and optical properties have been comparatively investigated by photophysical, electrochemical, and theoretical approaches. It is found that both the substituents and their conjugation extension directions have significant effects on the aromatic and photophysical properties of the B2N2‐embedded PAHs. The conjugation extension in the shorter backbone is more pronounced on the effective conjugation length than the longer backbone. Moreover, all the B2N2‐embedded PAHs behave as both Lewis acids and Lewis bases, and reversible photoluminescence switching can be observed by simply neutralizing the added Lewis acid or Lewis base.
Total Synthesis of the Death Cap Toxin Phalloidin: Atropoisomer Selectivity Explained by Molecular‐Dynamics Simulations
Authors: Yao Guiyang , Joswig Jan‐Oliver , Keller Bettina G. , Süssmuth Roderich D. 
Published: May 2019

AbstractPhallotoxins and amatoxins are a group of prominent peptide toxins produced by the death cap mushroom Amanita phalloides. Phalloidin is a bicyclic cyclopeptide with an unusual tryptathionin thioether bridge. It is a potent stabilizer of filamentous actin and in a fluorescently labeled form widely used as a probe for actin binding. Herein, we report the enantioselective synthesis of the key amino acid (2S,4R)‐4,5‐dihydroxy‐leucine as a basis for the first total synthesis of phalloidin, which was accomplished by two different synthesis strategies. Molecular‐dynamics simulations provided insights into the conformational flexibility of peptide intermediates of different reaction strategies and showed that this flexibility is critical for the formation of atropoisomers. By simulating the intermediates, rather than the final product, molecular‐dynamics simulations will become a decisive tool in orchestrating the sequence of ring formation reactions of complex cyclic peptides.
Prognostic accuracy of patients, caregivers, and oncologists in advanced cancer
Authors: Malhotra Kirti , Fenton Joshua J. , Duberstein Paul R. , Epstein Ronald M. , Xing Guibo , Tancredi Daniel J. , Hoerger Michael , Gramling Robert , Kravitz Richard L. 
Published: May 2019

BackgroundIn caring for patients with advanced cancer, accurate estimation of survival is important for clinical decision making. The purpose of this study was to assess the accuracy of 2‐year survival probabilities estimated by oncologists, patients, and caregivers and to identify demographic and clinical factors associated with prognostic accuracy.MethodsThis was a secondary observational analysis of data obtained from a cluster randomized controlled trial. Participants included 38 oncologists, 263 patients with advanced nonhematologic cancer, and 193 of their caregivers from clinics in Sacramento and Western New York. Discrimination within each group (oncologists, patients, caregivers) was evaluated using the C statistic, whereas calibration was assessed by comparing observed to predicted 2‐year mortality using the chi‐square statistic.ResultsThe median survival from study entry was 18 months, and 41.8% of patients survived for 2 years. C statistics for oncologists, patients, and caregivers were 0.81 (95% CI, 0.76‐0.86), 0.62 (95% CI, 0.55‐0.68), and 0.72 (95% CI, 0.65‐0.78), respectively; oncologists’ predictions were better than the predictions of both patients (P = .001) and caregivers (P = .03). Oncologists also had superior calibration: their predictions of 2‐year survival were similar to actual survival (P = .17), whereas patients’ (P = .0001) and caregivers’ (P = .003) predictions diverged significantly from actual survival. Although most oncologists’ predictions were classified as realistic (62.0%), approximately one‐half of patients’ and caregivers’ predictions (50.0% and 46.0%, respectively) were unduly optimistic. Among patients, nonwhite race and higher levels of social well‐being predicted undue optimism (P < .05).ConclusionsCompared with oncologists, patients and caregivers displayed inferior prognostic discrimination, and their predictions were poorly calibrated, primarily because of overoptimism.
Antitumor efficacy of arsenic/interferon in preclinical models of chronic myeloid leukemia resistant to tyrosine kinase inhibitors
Authors: El Eit Rabab , Itani Abdul Rahman , Nassar Farah , Rasbieh Nagham , Jabbour Mark , Santina Ahmad , Zaatari Ghazi , Mahon François‐Xavier , Bazarbachi Ali , Nasr Rihab 
Published: May 2019

BackgroundTyrosine kinase inhibitors (TKIs) are the standard treatment for chronic myeloid leukemia (CML). Despite their clinical success, TKIs are faced with challenges such as treatment resistance, which may be driven by kinase domain mutations, and frequent disease relapse upon the cessation of treatment. The combination of arsenic trioxide (ATO) and interferon‐α (IFN) was previously demonstrated to inhibit proliferation and induce apoptosis in CML cell lines, prolong the survival of primary wild‐type CML mice, and dramatically decrease the activity of leukemia‐initiating cells (LICs).MethodsThe ATO/IFN combination was tested in vitro on imatinib (IMN)‐resistant K562‐R and Ar230‐R cells. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick‐end labeling assays were used to evaluate proliferation and apoptosis, respectively. The acridine orange assay was used to assess autophagy, and quantitative reverse transcription–polymerase chain reaction was used to assess the involvement of the hedgehog (Hh) pathway. In vivo, a retroviral transduction/transplantation T315I BCR‐ABL CML mouse model was used to assay the effect of the treatment on survival, tumor burden (histopathology and blood counts), and LIC activity (secondary transplantation).ResultsIn vitro, ATO/IFN synergized to inhibit proliferation and induce apoptosis of IMN‐resistant cells with variant modes of resistance. Furthermore, the preclinical effects of ATO/IFN were associated with induction of autophagy along with inhibition of the Hh pathway. Most remarkably, ATO/IFN significantly prolonged the survival of primary T315I‐CML mice and displayed a dramatic impairment of disease engraftment in secondary mice, which reflected decreased LIC activity.ConclusionsCollectively, the ATO/IFN strategy has been demonstrated to have the potential to lead to durable remissions in TKI‐resistant CML preclinical models and to overcome various TKI‐specific mechanisms of resistance.
Poorly controlled diabetes increases the risk of metastases and castration‐resistant prostate cancer in men undergoing radical prostatectomy: Results from the SEARCH database
Authors: Nik‐Ahd Farnoosh , Howard Lauren E. , Eisenberg Adva T. , Aronson William J. , Terris Martha K. , Cooperberg Matthew R. , Amling Christopher L. , Kane Christopher J. , Freedland Stephen J. 
Published: May 2019

BackgroundAlthough diabetes is inversely related to prostate cancer (PC) risk, to the authors’ knowledge the impact of glycemic control on PC progression is unknown. In the current study, the authors tested the association between hemoglobin A1c (HbA1c) and long‐term PC outcomes among diabetic men undergoing radical prostatectomy (RP).MethodsThe authors retrospectively reviewed data regarding men undergoing RP from 2000 to 2017 at 8 Veterans Affairs hospitals. Diabetic patients were identified using International Classification of Diseases, Ninth Revision (ICD‐9) codes (250.x) or by an HbA1c value >6.5% at any time before RP. Cox models tested the association between HbA1c and biochemical disease recurrence (BCR), castration‐resistant PC (CRPC), metastases, PC‐specific mortality, and all‐cause mortality. The model for BCR was adjusted for multiple variables. Due to limited events, models for long‐term outcomes were adjusted for biopsy grade and prostate‐specific antigen only.ResultsA total of 1409 men comprised the study population. Of these, 699 patients (50%) had an HbA1c value <6.5%, 631 (45%) had an HbA1c value of 6.5% to 7.9%, and 79 (6%) had an HbA1c value ≥8.0%. Men with an HbA1c value ≥8.0% were younger (P < .001) and more likely to be black (P = .013). The median follow‐up after RP was 6.8 years (interquartile range, 3.7‐10.6 years). On multivariable analysis, HbA1c was not found to be associated with BCR. However, a higher HbA1c value was associated with metastasis (hazard ratio [HR], 1.21; 95% CI, 1.02‐1.44 [P = .031]) and CRPC (HR, 1.27; 95% CI, 1.03‐1.56 [P = .023]). Although not statistically significant, there were trends between higher HbA1c and risk of PC‐specific mortality (HR, 1.24; 95% CI, 0.99‐1.56 [P = .067]) and all‐cause mortality (HR, 1.09; 95% CI, 0.99‐1.19 [P = .058]).ConclusionsAmong diabetic men undergoing RP, a higher HbA1c value was associated with metastases and CRPC. If validated in larger studies with longer follow‐up, future research should test whether better glycemic control improves long‐term PC outcomes.
Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy
Authors: Demissei Biniyam G. , Finkelman Brian S. , Hubbard Rebecca A. , Zhang Liyong , Smith Amanda M. , Sheline Karyn , McDonald Caitlin , Narayan Hari K. , Narayan Vivek , Waxman Adam J. , Domchek Susan M. , DeMichele Angela , Shah Payal , Clark Amy S. , Bradbury Angela R. , Carver Joseph R. , Upshaw Jenica , Armenian Saro H. , Liu Peter , Ky Bonnie 
Published: May 2019

BackgroundBreast cancer therapies are associated with a risk of cardiac dysfunction, most commonly defined by changes in left ventricular ejection fraction (LVEF). Recently, the authors identified 3 classes of LVEF change after exposure to anthracyclines and/or trastuzumab using latent class growth modeling. The objective of the current study was to characterize the clinical, biochemical, and functional profiles associated with LVEF trajectory class membership.MethodsTransthoracic echocardiography and biomarker assessments were performed and questionnaires were administered at standardized intervals in a longitudinal cohort of 314 patients with breast cancer who were treated with anthracyclines and/or trastuzumab. Univariable and multivariable multinomial regression analyses evaluated associations between baseline variables and LVEF trajectory class membership. Generalized estimating equations were used to define mean changes in cardiovascular measures over time within each class.ResultsAmong the 3 distinct subgroups of LVEF changes identified (stable [class 1]; modest, persistent decline [class 2]; and significant early decline followed by partial recovery [class 3]), higher baseline LVEF, radiotherapy, and sequential therapy with anthracyclines and/or trastuzumab were associated with class 2 or 3 membership. Sustained abnormalities in longitudinal strain and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) were observed in patients in class 2, as were heart failure symptoms. Similar abnormalities were observed in patients in class 3, but there was a trend toward recovery, particularly for longitudinal strain.ConclusionsPatients with modest, persistent LVEF declines experienced sustained abnormalities in imaging and biochemical markers of cardiac function and heart failure symptoms. Further investigation is needed to characterize the long‐term risk of heart failure, particularly in those with modest LVEF declines.
Enhancing High Humidity Stability of Quasi‐2D Perovskite Thin Films through Mixed Cation Doping and Solvent Engineering
Authors: Naikaew Atittaya , Kumnorkaew Pisist , Supasai Thidarat , Suwanna Sujin , Hunkao Rutchapon , Srikhirin Toemsak , Kanjanaboos Pongsakorn 
Published: May 2019

AbstractPerovskite materials show excellent photovoltaic performance along with simple processing and low‐energy requirements. Despite their high power conversion efficiency (PCE), instability in the presence of moisture is still a major challenge. An effective method to enhance perovskite stability is by reducing dimensionality through incorporation of long organic cations into the perovskite crystal, which improves charge‐carrier extraction efficiency of the perovskites compared to conventional 3D perovskites. Quasi‐2D perovskites or 2D/3D perovskites strike a good balance between PCE and stability, having much improved stability compared to 3D structures while retaining excellent optoelectronic properties. Yielding better thermal stability and broader absorption into the near‐infrared, formamidinium iodide (FAI) doping has positive influences yet tends to cause poor surface morphology. Here, we introduce highly stable MA/FA‐based quasi‐2D perovskite fabricated by mixed cation doping (MCD), which is repeated deposition of MA and FA cations onto a quasi‐2D perovskite layer. MCD enables better morphology and surface passivation, leading to fewer defects. MA/FA‐based quasi‐2D perovskite with quasi‐cubic structure has high humidity resistivity, remaining intact after 90 days under 60% relative humidity without encapsulation. The underlying mechanism is further explained by binding and formation energies of cation mixture in solution and perovskite structure through computational analysis.