bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature thresholds for germination in 20 short‐range endemic plant species from a Greenstone Belt in southern Western Australia
Authors: Cochrane A. 
Published: December 2018

Abstract

The study of climate‐driven effects on seed traits such as germination has gained momentum over the past decade as the impact of global warming becomes more apparent on the health and survival of plant diversity.

Seed response to warming was evaluated in a suite of short‐range endemic species from the biodiverse Greenstone Belt of southern Western Australia. The temperature dimensions for germination in 20 woody perennials were identified using small unreplicated samples over 6 weeks on a temperature gradient plate (constant and fluctuating temperatures between 5 and 40 °C). These data were subsequently modelled against current and forecast (2070) mean monthly minimum and maximum temperatures to illustrate seasonal changes to germination timing and final percentage germination.

All but one species attained full germination in at least one cell on the gradient plate. Modelling of the data suggested only minimal changes to percentage germination despite a forecast rise in diurnal temperatures over the next 50 years. Nine species were predicted to experience declines of between <1% and 7%, whilst 11 species were predicted to increase their germination by <1% to 3%. Overall, the speed of germination is predicted to increase but the timing of germination for most species shifts seasonally (both advances and delays) as a result of changing diurnal temperatures.

The capacity of this suite of species to cope with warmer temperatures during a critical early life stage shows a degree of adaptation to heterogeneous environments. Predicting the effects of global change on terrestrial plant communities is crucial to managing and conserving plant diversity.
Electrophysiology as a theoretical and methodological hub for the neural sciences
Authors: Cavanagh James F. 
Published: December 2018

AbstractElectrophysiology is a direct measure of neuronal processes, and it is uniquely sensitive to canonical neural operations that underlie emergent psychological operations. These qualities make it well suited for discovery of aberrant neural mechanisms that underlie complicated disease states. This technique is routinely utilized in vitro, in vivo, and in outpatient neurological clinics, offering a translatable bridge between animal models and human patients. The bench‐to‐bedside potential of this approach is unparalleled, yet it also remains undeveloped due to the slow inertia of legacy techniques and interpretations. In this review, I discuss these strengths of the method, and I detail compelling reasons why future advancements can have a direct and tangible influence over clinical practice. I hope to motivate a blurring of traditional boundaries between preclinical, computational, imaging, and clinical fields by advancing electrophysiology as a common hub for methodological integration and theoretical advancement.
Pharmacokinetics and important drug–drug interactions to remember when treating advanced chronic kidney disease patients with hepatitis C direct acting anti‐viral therapy
Authors: Cohen Elizabeth , Liapakis AnnMarie 
Published: December 2018

AbstractHepatitis C direct acting antiviral (DAA) therapy has evolved so that infected patients with advanced chronic kidney disease (CKD) can now anticipate the opportunity for sustained virologic response equivalent to that of the broader population of patients with hepatitis C. This has revolutionized the field of transplantation as it relates to renal transplant candidates with hepatitis C and the use of grafts from hepatitis C virus (HCV) viremic donors. In treating this population of patients, special consideration must be given to the timing of anti‐viral therapy and drug–drug interactions. Herein we review the pharmacokinetics of HCV DAA therapy in the setting of CKD and chronic renal replacement therapy. Highlighted are drug/drug interactions with special attention to therapies utilized in advanced CKD and immunosuppressants.
The six dimensions of parenting and adolescent psychological adjustment: The mediating role of psychological needs
Authors: Costa Sebastiano , Sireno Simona , Larcan Rosalba , Cuzzocrea Francesca 
Published: December 2018

In accordance with the Self‐determination Theory (SDT), six dimensions of parenting (autonomy support vs. psychological control, structure vs. chaos, warmth vs. rejection) could be defined in their relation to adolescents’ adjustment. However, the mechanisms of these relations need to be further deepened. In accordance with SDT, the aims of this study were: (1) to examine the relationships between the six dimensions of parenting and the three psychological basic needs; (2) to examine the mediation role of basic psychological needs in the relation between parental practices, and positive and negative outcomes in a sample of Italian adolescents. In a sample of 342 adolescents, results suggest that supportive parenting practice (autonomy support, structure, and warmth) promotes need fulfillment and adjustment, while thwarting parenting practice (psychological control, chaos, and rejection) reduces need fulfillment and adjustment. Furthermore, the three psychological basic needs (autonomy, competence and relatedness) mediate the relations between parenting and adolescents’ adjustment. These findings highlight the role of parenting in adolescents’ adjustment and in line with SDT provide evidence of the dynamic between parenting, psychological needs and adjustment.
What is so frightening about spiders? Self‐rated and self‐disclosed impact of different characteristics and associations with phobia symptoms
Authors: Lindner Philip , Miloff Alexander , Reuterskiöld Lena , Andersson Gerhard , Carlbring Per 
Published: December 2018

Spider phobia is a common and impairing mental disorder, yet little is known about what characteristics of spiders that spider phobic individuals find frightening. Using screening data from a clinical trial, we explored which characteristics that spider‐fearful individuals (n = 194) rated as having the greatest impact on fear, used factor analysis to group specific characteristics, and explored linear associations with self‐reported phobia symptoms. Second, a guided text‐mining approach was used to extract the most common words in free‐text responses to the question: “What is it about spiders that you find frightening?” Both analysis types suggested that movement‐related characteristics of spiders were the most important, followed by appearance characteristics. There were, however, no linear associations with degree of phobia symptoms. Our findings reveal the importance of targeting movement‐related fears in in‐vivo exposure therapy for spider phobia and using realistically animated spider stimuli in computer‐based experimental paradigms and clinical interventions such as Virtual Reality exposure therapy.
Human tularaemia associated with exposure to domestic dogs—United States, 2006–2016
Authors: Kwit Natalie A. , Schwartz Amy , Kugeler Kiersten J. , Mead Paul S. , Nelson Christina A. 
Published: December 2018

AbstractDogs have been implicated in the zoonotic transmission of numerous pathogens. Whereas cats are known to transmit Francisella tularensis to humans via bite and other routes, the role of dogs in facilitating infection is much less understood. We reviewed tularaemia case investigation records collected through national surveillance during 2006–2016 to summarize those with dog involvement, characterize the nature of dog‐related exposure and describe associated clinical characteristics. Among 1,814 human tularaemia cases, 735 (41%) supplemental case investigation records were available for review; and of those, 24 (3.3%) were classified as dog‐related. Median age of patients was 51 years (range: 1–82); 54% were female. Two thirds (67%) of cases presented with ulceroglandular/glandular tularaemia; pneumonic (13%) and oropharyngeal (13%) illness occurred less frequently. Dog‐related exposures were classified as follows: direct contact via bite, scratch or face snuggling/licking (n = 12; 50%); direct contact with dead animals retrieved by domestic dogs (n = 8; 33%); and contact with infected ticks acquired from domestic dogs (n = 4; 17%). Prevention of dog‐related tularaemia necessitates enhanced tularaemia awareness and tick avoidance among pet owners, veterinarians, health care providers and the general public.
Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness
Authors: Tarpey Michael D. , Valencia Ana P. , Jackson Kathryn C. , Amorese Adam J. , Balestrieri Nicholas P. , Renegar Randall H. , Pratt Stephen J. P. , Ryan Terence E. , McClung Joseph M. , Lovering Richard M. , Spangenburg Espen E. 
Published: December 2018

Key points
Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function.
BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is expressed in skeletal muscle.
Skeletal muscle specific knockout of Brca1 in mice caused a loss of muscle quality, identifiable by reductions in muscle force production and mitochondrial respiratory capacity.
Loss of muscle quality was associated with a shift in muscle phenotype and an accumulation of mitochondrial DNA mutations.
These results demonstrate that BRCA1 is necessary for skeletal muscle function and that increased mitochondrial DNA mutations may represent a potential underlying mechanism.
AbstractRecent evidence suggests that the breast cancer 1 early onset gene (BRCA1) influences numerous peripheral tissues, including skeletal muscle. The present study aimed to determine whether induced‐loss of the breast cancer type 1 susceptibility protein (Brca1) alters skeletal muscle function. We induced genetic ablation of exon 11 in the Brca1 gene specifically in the skeletal muscle of adult mice to generate skeletal muscle‐specific Brca1 homozygote knockout (Brca1KOsmi) mice. Brca1KOsmi exhibited kyphosis and decreased maximal isometric force in limb muscles compared to age‐matched wild‐type mice. Brca1KOsmi skeletal muscle shifted toward an oxidative muscle fibre type and, in parallel, increased myofibre size and reduced capillary numbers. Unexpectedly, myofibre bundle mitochondrial respiration was reduced, whereas contraction‐induced lactate production was elevated in Brca1KOsmi muscle. Brca1KOsmi mice accumulated mitochondrial DNA mutations and exhibited an altered mitochondrial morphology characterized by distorted and enlarged mitochondria, and these were more susceptible to swelling. In summary, skeletal muscle‐specific loss of Brca1 leads to a myopathy and mitochondriopathy characterized by reductions in skeletal muscle quality and a consequent kyphosis. Given the substantial impact of BRCA1 mutations on cancer development risk in humans, a parallel loss of BRCA1 function in patient skeletal muscle cells would potentially result in implications for human health.
In-hospital dementia-related deaths following implementation of the national dementia plan: observational study of national death certificates from 1996 to 2016
Authors: Nakanishi Miharu , Yamasaki Syudo , Nishida Atsushi 
Published: December 2018

ObjectiveTo examine changes in places of dementia-related death following implementation of the national dementia plan and other policy initiatives.DesignObservational study.SettingJapan between October 1996 and September 2016. Four major changes in health and social care systems were identified: (1) the public long-term care insurance programme (April 2000); (2) community centres as a first access point for older residents (April 2006); (3) medical care system for older people (April 2008) and (4) the national dementia plan (April 2013).Participants9 60 423 decedents aged 65 years or older whose primary cause of death was Alzheimer’s disease, vascular or other types of dementia or senility.Main outcome measuresPlace of death which was classified into ‘hospital’, ‘intermediate geriatric care facility’ (rehabilitation facility aimed at home discharge), ‘nursing home’ or ‘own home’.ResultsThe annual number of deaths at hospital was consistently increased over time from 1996 to 2016 (age-adjusted OR: 6.01; 95% CI 5.81 to 6.21 versus home deaths). Controlling for individual characteristics, regional supply of hospital and nursing home beds and other changes in health and social care systems, death from dementia following the national dementia plan was likely to occur in hospital (adjusted OR: 1.21; 95% CI 1.18 to 1.24), intermediate geriatric care facility (adjusted OR: 1.53; 95% CI 1.48 to 1.58) or nursing home (adjusted OR: 1.64; 95% CI 1.60 to 1.69) rather than at home.ConclusionsAs the number of deaths from dementia increased over the decades, in-hospital deaths increased regardless of the national dementia plan. Further strategies should be explored to improve the availability of palliative and end-of-life care at patients’ places of residence.
Exploring patient-reported outcomes of home-based cardiac rehabilitation in relation to Scottish, UK and European guidelines: an audit using qualitative methods
Authors: Ranaldi Hannah , Deighan Carolyn , Taylor Louise 
Published: December 2018

ObjectivesThe Heart Manual (HM) is the UK’s leading facilitated home-based cardiac rehabilitation (CR) programme for individuals recovering from myocardial infarction and revascularisation. This audit explored patient-reported outcomes of home-based CR in relation to current Scottish, UK and European guidelines.SettingPatients across the UK returned their questionnaire after completing the HM programme to the HM Department (NHS Lothian).ParticipantsQualitative data from 457 questionnaires returned between 2011 and 2018 were included for thematic analysis. Seven themes were identified from the guidelines. This guided initial deductive coding and provided the basis for inductive subthemes to emerge.ResultsThemes included: (1) health behaviour change and modifiable risk reduction, (2) psychosocial support, (3) education, (4) social support, (5) medical risk management, (6) vocational rehabilitation and (7) long-term strategies and maintenance. Both (1) and (2) were reported as having the greatest impact on patients' daily lives. Subthemes for (1) included: guidance, engagement, awareness, consequences, attitude, no change and motivation. Psychosocial support comprised: stress management, pacing, relaxation, increased self-efficacy, validation, mental health and self-perception. This was followed by (3) and (4). Patients less frequently referred to (5), (6) and (7). Additional themes highlighted the impact of the HM programme and that patients attributed the greatest impact to a combination of all the above themes.ConclusionsThis audit highlighted the HM as comprehensive and inclusive of key elements proposed by Scottish, UK and EU guidelines. Patients reported this had a profound impact on their daily lives and proved advantageous for CR.
Interventions targeted at health professionals to reduce unnecessary caesarean sections: a qualitative evidence synthesis
Authors: Kingdon Carol , Downe Soo , Betran Ana Pilar 
Published: December 2018

ObjectiveTo establish the views and experiences of healthcare professionals in relation to interventions targeted at them to reduce unnecessary caesareans.DesignQualitative evidence synthesis.SettingStudies undertaken in high-income, middle-income and low-income settings.Data sourcesSeven databases (CINAHL, MEDLINE, PsychINFO, Embase, Global Index Medicus, POPLINE and African Journals Online). Studies published between 1985 and June 2017, with no language or geographical restrictions. We hand-searched reference lists and key citations using Google Scholar.Study selectionQualitative or mixed-method studies reporting health professionals’ views.Data extraction and synthesisTwo authors independently assessed study quality prior to extraction of primary data and authors’ interpretations. The data were compared and contrasted, then grouped into summary of findings (SoFs) statements, themes and a line of argument synthesis. All SoFs were Confidence in the Evidence from Reviews of Qualitative research (GRADE-CERQual) assessed.Results17 papers were included, involving 483 health professionals from 17 countries (nine high-income, six middle-income and two low-income). Fourteen SoFs were identified, resulting in three core themes: philosophy of birth(four SoFs); (2)social and cultural context(five SoFs); and (3)negotiation within system(five SoFs). The resulting line of argument suggests three key mechanisms of effect for change or resistance to change: prior beliefs about birth; willingness or not to engage with change, especially where this entailed potential loss of income or status (including medicolegal barriers); and capacity or not to influence local community and healthcare service norms and values relating to caesarean provision.ConclusionFor maternity care health professionals, there is a synergistic relationship between their underpinning philosophy of birth, the social and cultural context they are working within and the extent to which they were prepared to negotiate within health system resources to reduce caesarean rates. These findings identify potential mechanisms of effect that could improve the design and efficacy of change programmes to reduce unnecessary caesareans.PROSPERO registration numberCRD42017059455.
Poststroke depression and risk of stroke recurrence and mortality: protocol of a meta-analysis and systematic review
Authors: Cai Wa , Stewart Robert , Mueller Christoph , Li Yi-Jing , Shen Wei-Dong 
Published: December 2018

IntroductionA number of observational studies have indicated that poststroke depression could increase the risk of stroke outcomes. There is a meta-analysis indicating that poststroke depression is a risk factor of all-cause mortality. This paper reports the protocol for a systematic review and meta-analysis to clarify the associations of poststroke depression with stroke recurrence and mortality in order to determine whether poststroke depression is a predictor of stroke outcomes according to data extracted from relevant observational studies.Methods and analysisMEDLINE, Web of Science databases, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews will be used to conduct the search. Published studies written in English will be included. The risk of bias for the studies included in the systematic review or meta-analysis will be assessed by the Newcastle–Ottawa Quality Assessment Scale. HRs for stroke recurrence and mortality with 95% CIs will be included as primary outcomes. Subgroup analyses and meta-regression will be performed.Ethics and disseminationEthics approval will not be needed because the data used in this systematic review will be extracted from published studies. The results of the systematic review focusing on whether depression after stroke is a predictor for stroke recurrence and mortality will be disseminated by publication in a peer-reviewed journal.PROSPERO registration numberCRD42018107944.
Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation
Authors: Bakkestrøm Rine , Banke Ann , Pecini Redi , Irmukhamedov Akhmadjon , Nielsen Søren Kristian , Andersen Mads J , Borlaug Barry A , Moller Jacob Eifer 
Published: December 2018

ObjectiveTo assess the association between cardiac morphology and function assessed with cardiac MRI (CMRI) and haemodynamics at rest and during exercise in patients with primary mitral regurgitation (MR).MethodsIn an observational study, subjects with significant primary MR (N = 46) with effective regurgitant orifice ≥ 0.30 cm2and left ventricular (LV) ejection fraction > 60% were examined with right heart catheterisation during rest and exercise and CMRI at rest. End-diastolic pressure volume relationship (EDPVR) was assessed using a single beat method using pulmonary capillary wedge pressure (PCWP) and end-diastolic volume. Patients were divided according to normal PCWP at rest (> 12 mm Hg) and with exercise (> 28 mm Hg). Results: Resting regurgitant volume correlated positively with resting PCWP, (r = 0.42, p = 0.002). However, with exercise no association between PCWP and regurgitant volume was seen (r = 0.09, p = 0.55). At rest left atrial (LA) maximal, minimal and volume index at atrial contraction correlated positively with PCWP (r = 0.60; r = 0.55; r = 0.58, all p < 0.001); in contrast none of these correlated with exercise PCWP (all p > 0.2). EDPVR in patients with high PCWP at rest was shifted towards higher volumes for the same pressures. The opposite was seen for patients with high PCWP during exercise where estimated volumes were smaller for the same pressure than patients with normal exercise PCWP.ConclusionIn patients with significant MR the degree of regurgitation and LA dilatation is associated with resting PCWP. However, with exercise this association disappears. Estimation of EDPVR suggests lower LV compliance in patients where PCWP is increased with exercise.Clinical trial registrationURL:https://clinicaltrials.gov/ct2/show/NCT02961647?term=HEMI&rank=1. ID:NCT02961647
FINN-
R
Authors: Blott Michaela , Preußer Thomas B. , Fraser Nicholas J. , Gambardella Giulio , O’brien Kenneth , Umuroglu Yaman , Leeser Miriam , Vissers Kees 
Published: December 2018

Convolutional Neural Networks have rapidly become the most successful machine-learning algorithm, enabling ubiquitous machine vision and intelligent decisions on even embedded computing systems. While the underlying arithmetic is structurally simple, compute and memory requirements are challenging. One of the promising opportunities is leveraging reduced-precision representations for inputs, activations, and model parameters. The resulting scalability in performance, power efficiency, and storage footprint provides interesting design compromises in exchange for a small reduction in accuracy. FPGAs are ideal for exploiting low-precision inference engines leveraging custom precisions to achieve the required numerical accuracy for a given application. In this article, we describe the second generation of the FINN framework, an end-to-end tool that enables design-space exploration and automates the creation of fully customized inference engines on FPGAs. Given a neural network description, the tool optimizes for given platforms, design targets, and a specific precision. We introduce formalizations of resource cost functions and performance predictions and elaborate on the optimization algorithms. Finally, we evaluate a selection of reduced precision neural networks ranging from CIFAR-10 classifiers to YOLO-based object detection on a range of platforms including PYNQ and AWS F1, demonstrating new unprecedented measured throughput at 50 TOp/s on AWS F1 and 5 TOp/s on embedded devices.