bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor fibroso solitario gigante de pleura en paciente joven
Authors: Beltrán-García, MD, MSc Tatiana Carolina , Vargas-Parada, Est Isabella , Amaya-Dueñas, Est Camilo Andrés , López-Ordóñez, MD, MSc Mario Andrés 
Published: June 2019

Introducción: el tumor fibroso solitario de pleura (tfsp) es una patología poco frecuente, corresponde a menos del 5 % de los tumores primarios de pleura, siendo aún más raros los tumores mayores de 15 cm y aquellos en pacientes menores de 35 años, ya que el pico de incidencia es entre los 60 a 70 años con un solo caso reportado en Colombia. Presentación de caso: paciente femenina de 33 años, sin exposición a asbesto o cigarrillo. Consultó por cuadro de disnea de moderados esfuerzos y dolor dorsal derecho. La tomografía axial computarizada (TAC) contrastada de tórax evidenció una gran masa sólida de contornos lobulados que comprometía el 70 % del hemitórax derecho de origen extrapulmonar y que comprimía la aurícula derecha, la inmunohistoquímica de la biopsia percutánea clasificó la lesión como tumor fibroso solitario. Fue llevada a toracotomía posterolateral derecha extendida, donde se encontró un tumor dependiente de la pleura parietal derecha resecado en su totalidad. Histopatología e inmunohistoquímica del producto de resección quirúrgica, compatibles con tumor fibroso solitario de pleura, tamaño 30 x 23 x 16 cm sin características de malignidad. La evolución posoperatoria fue satisfactoria, se logró un egreso hospitalario temprano. Discusión: en una paciente joven, el TFSP gigante es inusual, posterior a su diagnóstico, y a pesar de tener algunas características que sugerían malignidad, tamaño y origen en la pleura parietal, la resección quirúrgica fue el tratamiento indicado para este tumor, con posterior confirmación histopatológica compatible con tumor benigno.
Optimal wound closure of diabetic foot ulcers with early initiation of TLC-NOSF treatment: post-hoc analysis of Explorer
Authors: Lázaro-Martínez José Luis , Edmonds Michael , Rayman Gerry , Apelqvist Jan , Van Acker Kristien , Hartemann Agnès , Martini Jacques , Lobmann Ralf , Bohbot Serge , Kerihuel Jean-Charles , Piaggesi Alberto 
Published: June 2019

Objective:In March 2018, the Explorer study, an international, double-blind, randomised controlled trial (RCT), established that adding a TLC-NOSF (UrgoStart Contact, Laboratoires Urgo, France) dressing to good local standard of care (SoC) significantly and substantially increases wound closure and reduces the healing time of neuroischaemic diabetic foot ulcers (DFU). Besides the TLC-NOSF treatment, the wound duration was the only other covariate that had an influence on the wound closure rate in the regression model used in the original study. The purpose of this work was to further document the impact of wound duration on the healing outcomes of the DFUs included in the Explorer study and to discuss complementary pragmatic observations on the TLC-NOSF effect.Method:In this post-hoc analysis of the Explorer data, the wound closure rates by week 20 are reported for the global cohort (n=240, Intention-to-treat population) and for the treated (n=126) and control groups (n=114) according to DFU duration and location.Results:For the combined group, wound closure rates decreased with the increase of wound duration at baseline (from 57% in wounds ≤2 months to 19% in wounds >11 months). Whatever the wound duration subgroups analysed, higher closure rates were reported in the TLC-NOSF group than in the control group. However, the maximal difference between the two treatments was reported in wounds with a duration of ≤2 months (71% versus 41%, 30 percentage points difference, Relative Risk 1.7, 95% Confidence Interval 1.1 to 2.8). Regarding wound location subgroup analyses, the outcomes were always in favour of the TLC-NOSF treatment, with closure rates ranging between 43% and 61% within the TLC-NOSF group, and between 25% and 40% within the control group.Conclusion:This clinical evidence supports that treating DFUs with TLC-NOSF dressing and good SoC results in higher wound closure rates than with a neutral dressing and the same good standard of care, whatever the duration and the location of the treated wounds. However, the earlier the TLC-NOSF dressing is initiated in DFU treatment, the greater the benefits.
Local treatment of pressure ulcers in long-term care: a correlational cross-sectional study
Authors: Stolt Minna , Hjerppe Anna , Hietanen Helvi , Puukka Pauli , Haavisto Elina 
Published: June 2019

Objective: To analyse the treatment of pressure ulcers (PU) in long-term care. Method: In this correlational cross-sectional study, data was collected between November 2015 and January 2016 from older people with PUs in private and public long-term care facilities in Finland. Data collection was conducted by trained nurses using the Pressure Ulcer Patient Instrument (PUP-Ins). Outcomes measured were: prevalence and localisation of PU, local PU treatment, frequency (how often/week/day) and duration (minutes/week or day) of PU treatment. Results: In total, 112 patients with 158 PUs were identified (a prevalence rate of 5%). PUs were located most often on the heel (38%), hip (13%), buttocks (10%) and lateral malleolus (9.5%). The most frequently used PU treatment was skin protecting agents and local wound care products. The most typical treatment in category I, II and III PUs were foam dressings. In category III PUs, ribbon gauze dressings were also used. The most typical products for category IV PUs were complex dressings. Category I PUs received more treatment per day or week than other categories of PUs. Conclusion: PU treatment is inconsistent and often conducted with varying methods and products. Holistic patient care must be the focus. Nurses in long-term care settings might benefit from in-depth in-service education focusing on the treatment of PUs. More research is needed about nurses' competence in PU treatment.
The Fairy Tales in Building Children Values
Authors: Fernandes Elaine Ferreira Banja , Jiménez Luis Ortiz 
Published: June 2019

Abstract: The present study aims to discuss the Construction of the Values of the Child from the fairy tales as didactic methodology in the classroom. Literature bridges knowledge and the human psyche. Fairy tales, in a psychoanalytic view, seek interpretation as a very important resource for the mental life of children. The results led to believe that one can consider the elements of myth, fantasy, and the unusual as developers of the human personality, for it is through the symbology that the person represents and expresses his thoughts and actions. It was concluded that, more and more, educators should use children's stories and fairy tales in their classes, enriching the possibilities of child associations with their daily reality. Keywords: Fairy tales; Construction of Human Values; Child education.
The fairy tales in building children values
Authors: Fernandes Elaine Ferreira Banja , Jiménez Luis Ortiz 
Published: June 2019

The present study aims to discuss the Construction of the Values of the Child from the fairy tales as didactic methodology in the classroom. Literature bridges knowledge and the human psyche. Fairy tales, in a psychoanalytic view, seek interpretation as a very important resource for the mental life of children. The results led to believe that one can consider the elements of myth, fantasy, and the unusual as developers of the human personality, for it is through the symbology that the person represents and expresses his thoughts and actions. It was concluded that, more and more, educators should use children's stories and fairy tales in their classes, enriching the possibilities of child associations with their daily reality. Keywords: Fairy tales; Construction of Human Values; Child education.
Molecular, Morphological, and Functional Characterization of Corticotropin-Releasing Factor Receptor 1-Expressing Neurons in the Central Nucleus of the Amygdala
Authors: Wolfe S. A. , Sidhu H. , Patel R. R. , Kreifeldt M. , D’Ambrosio S. R. , Contet C. , Roberto M. 
Published: June 2019

AbstractThe central nucleus of the amygdala (CeA) is a brain region implicated in anxiety, stress-related disorders and the reinforcing effects of drugs of abuse. Corticotropin-releasing factor (CRF,Crh)acting at cognate type 1 receptors (CRF1,Crhr1) modulates inhibitory and excitatory synaptic transmission in the CeA. Here, we used CRF1:GFP reporter mice to characterize the morphological, neurochemical and electrophysiological properties of CRF1-expressing (CRF1+) and CRF1-non-expressing (CRF1–) neurons in the CeA. We assessed these two neuronal populations for distinctions in the expression of GABAergic subpopulation markers and neuropeptides, dendritic spine density and morphology, and excitatory transmission. We observed that CeA CRF1+ neurons are GABAergic but do not segregate with calbindin (CB), calretinin (CR), parvalbumin (PV), or protein kinase C-δ (PKCδ). Among the neuropeptides analyzed,PenkandSsthad the highest percentage of co-expression withCrhr1in both the medial and lateral CeA subdivisions. Additionally, CeA CRF1+ neurons had a lower density of dendritic spines, which was offset by a higher proportion of mature spines compared to neighboring CRF1– neurons. Accordingly, there was no difference in basal spontaneous glutamatergic transmission between the two populations. Application of CRF increased overall vesicular glutamate release onto both CRF1+ and CRF1– neurons and does not affect amplitude or kinetics of EPSCs in either population. These novel data highlight important differences in the neurochemical make-up and morphology of CRF1+ compared to CRF1– neurons, which may have important implications for the transduction of CRF signaling in the CeA.
Sex and the Single Fly: A Perspective on the Career of Bruce S. Baker
Authors: Andrew Deborah J , Chen Elizabeth H , Manoli Devanand S , Ryner Lisa C , Arbeitman Michelle N 
Published: June 2019

Abstract
Bruce Baker's laboratory made a huge impact on our understanding of Drosophila sex determination mechanisms. To celebrate these accomplishments, members of Bruce's laboratory describe the trailblazing science that led to mechanistic understanding of how sex differences...
Bruce Baker, a preeminent Drosophila geneticist who made fundamental contributions to our understanding of the molecular genetic basis of sex differences, passed away July 1, 2018 at the age of 72. Members of Bruce’s laboratory remember him as an intensely dedicated, rigorous, creative, deep-thinking, and fearless scientist. His trainees also remember his strong commitment to teaching students at every level. Bruce’s career studying sex differences had three major epochs, where the laboratory was focused on: (1) sex determination and dosage compensation, (2) the development of sex-specific structures, and (3) the molecular genetic basis for sex differences in behavior. Several members of the Baker laboratory have come together to honor Bruce by highlighting some of the laboratory’s major scientific contributions in these areas.
Estructura interna de la Escala de Conciliación Vida-Trabajo para mujeres asalariadas del noreste de México
Authors: Hernández-Montaño Alicia , González-Tovar José 
Published: June 2019

Objetivo: Realizar la validación inicial de la estructura de la Escala de Conciliación Vida-Trabajo en mujeres insertas en el mercado laboral del noreste de México.
Método: Se utilizó un diseño cuantitativo de corte explicativo. El muestreo fue intencional, 554 mujeres mayores de 18 años y que desempeñan actividades laborales remuneradas. El instrumento contó con 35 reactivos organizados en ocho dimensiones: desarrollo personal, vida familiar, vida social, cuidado personal, alimentación, actividad física, satisfacción e interferencia.
Resultados: Se obtuvo la consistencia interna y el análisis factorial exploratorio (AFE) y confirmatorio (AFC). Se logró una reducción de ocho a seis dimensiones y de 35 a 25 reactivos. Una vez obtenidos estos valores, la escala tiene una adecuada estructura interna (GFI=0,867, RMSEA= 0,063) es válida y confiable (?=0,874) para evaluar el nivel de conciliación vida-familia de mujeres que se desempeñan en diferentes sectores laborales.
Conclusiones: La gratificación, interferencia, pareja y crianza, cuidado de la salud, responsabilidades en el hogar y tiempo libre son dimensiones de la ECVT que permiten identificar la estructura de la conciliación desde la perspectiva de las mujeres trabajadoras.
The Million Rand Question: Does a Civil Marriage Automatically Dissolve the Parties' Customary Marriage?
Authors: Osman Fatima 
Published: June 2019

In 2016 the Eastern Cape Local Division in Mthata heard a claim by Mrs Winnie Madikezela-Mandela that, amongst other things, her customary marriage to former President Nelson Mandela continued to exist until his death, despite the dissolution of their civil marriage. Not long thereafter, in 2017, former President Jacob Zuma's daughter made headlines by claiming half of her soon-to-be-ex-husband's multimillion-rand estate despite the couple’s having entered into a valid ante-nuptial contract. The claim was that her preceding customary marriage had not been accompanied by an ante-nuptial contract, and therefore the marriage was in community of property. These high-profile cases raise the fundamental legal question: what effect does a civil marriage between parties have on the parties' customary marriage to each other?
Historically the subsequent civil marriage terminated the customary marriage, as such marriages were not legally recognised in South Africa. The Recognition of Customary Marriages Act 120 of 1998 allows for such dual marriages without specifying the consequences thereof. Most commentators have interpreted the provisions to perpetuate the historical position; the civil marriage terminates the customary marriage. While this appears distasteful, the rationale is legal certainty and accords with the recommendations of the South African Law Commission. Furthermore, alternative customary dispute resolution mechanisms are still available to the parties, who are unlikely to suffer prejudice under the interpretation. In addition, given the social reality in which dual marriages are conducted and how they are perceived by parties, parties should be allowed to conclude an ante-nuptial contract after their customary marriage but before their civil marriage to regulate the proprietary consequences of their marriage.
Government Intervention and Suburban Sprawl
Authors: Soni (Govindjee) Urmila 
Published: June 2019

The writer is of the opinion that government intervention is the probable cause of suburban sprawl in American cities. Two types of sprawl are discussed, namely, sprawl which results due to to the creation of suburbs and sprawl arising from the inability to be mobile without the use of one's personal transport. The writer makes use of comparative tables and statistics to add credibility to the findings. The school system, the creation of highways, making jay-walking a crime and the legal obligation to provide huge parking lots for shopping centres are some of the unusual reasons why there has been excessive sprawl in American cities.
Solutions are suggested to counter government intervention. Although the study is USA based, book could have universal appeal. However, as acknowledged by the writer, the cost that will have to be incurrred, may be a barrier.
Beckett e música : composição do tempo
Authors: Ferraz Silvio 
Published: June 2019

Beckett tinha uma grande proximidade com a música. Isto é registrado em diversas de suas cartas, entrevistas e mesmo atravessa sua produção. Mas de que música estamos falando quando falamos de Beckett? Neste artigo busco mostrar a proximidade entre o pensamento compositivo de Beckett e aquelas propostas que permearam a música experimental do século XX: o serialismo integral, o tratamento do tempo, do silêncio e a importância da sonoridade. Para tanto faço uso das noções de tempo trabalhadas pelos compositores Iannis Xenakis e Gérard Grisey, e de uma análise de momentos da obra radiofônica Cascando, nas suas versões da RTF em 1963 e BBC3 em 1964.Palavras-chave: Cascando, serialismo integral, silêncio, tempo musical, Xenakis, Grisey.Abstract: It is very known that music was strongly related to Beckett quotidian. Music is always present in letters, interviews, plays and narratives. But what music we are thinking when having Beckett thought in mind? In this paper I tried to put together Beckett writing thought, his compositional thought, with the main propositions of the XX Century Music as: integral serialism, the ideas of time, the presence of the silence and the importance of the sound. In that sense, I take notions of time from composers as Iannis Xenakis and Gérard Grisey, to analyses the presence of time and silence in the composition of Beckett’s Cascando, in its two versions - RTF in 1963 and BBC3 in 1964.Key-words: Cascando, integral serialism, silence, musical time, Xenakis, Grisey.
Cena de escuta – a voz como objeto pulsional em Companhia, de Samuel Beckett
Authors: Sagayama Mario 
Published: June 2019

Neste artigo, busquei apontar alguns aspectos fundamentais para uma leitura sobre a voz em Companhia (1980), um dos últimos romances do autor, primeiro da trilogia Nohow on. A partir da psicanálise lacaniana, a voz aqui é posta entre palavra e silêncio, entre escuta e escrita, entre a inclusão do leitor e o chamado àquele que está “deitado de costas no escuro”. Palavras-chave: Samuel Beckett, voz, psicanálise, prosa, drama. Abstract: In this article, I made an effort to point out some fundamental aspects for an interpretation of the voice on Company (1980), one of the last novels of the author, the first volume of the Nohow on’s trilogy. From lacanian psychoanalysis, the voice is placed between word and silence, listening and writing, between the inclusion of the reader and the call for the “one on his back in the dark”.Key-words: Samuel Beckett, voice, psychoanalysis, prose, drama.
Incretin Hormones in the Control of Immunometabolism
Authors: Fishman Sigal , Zvibel Isabel , Varol Chen 
Published: June 2019

Abstract
Incretin peptides, mainly glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), are gut derived hormones secreted upon cues from ingested food that regulate glucose concentration, lipid metabolism and gut motility. The classic role of incretins is to convey the status of nutrient availability from the gut to the brain, initiating changes in eating behavior and energy expenditure to maintain body weight. Incretins also act directly on metabolically important peripheral targets in a highly concerted fashion to maintain energy balance and glucose homeostasis. As a result, a myriad of therapeutics for metabolic diseases based on the actions of incretins, particularly GLP-1, are currently under clinical development. Multiple immune cell subsets express receptors for GLP-1 and GIP, but their immunoregulatory roles remain incompletely understood. Innate and adaptive immune cells are intertwined in the homeostatic regulation of central and peripheral metabolism and energy balance, but also contribute to their impairment in the context of metabolic syndrome-related diseases. Hence, delineating the cellular and signaling networks by which incretins operate at the immunometabolic interface has a remarkable translational relevance. In this review, we concisely describe the well-characterized metabolic functions of GLP-1 and GIP, and offer an unprecedented view on the ability of these hormones to modulate immune responses via their direct action on immune cells.
Acute Tubular Necrosis from Rhabdomyolysis from Leg Compartment Syndrome
Authors: DeWolf Matthew C. , Norman Mackenzie B. , Molloy Ilda B. , Yong Taylor M. , Ramkumar Dipak B. , Veerareddy Rakesh R. 
Published: June 2019

Case:
A 31-year-old male sustained acute compartment syndrome to his left leg after a low-energy fall and required a 4-compartment fasciotomy release. His immediate postoperative course was complicated by acute tubular necrosis (ATN) with creatinine elevated to 4.89 mg/dL from rhabdomyolysis. ATN was managed with aggressive hydration, sodium bicarbonate, and alkaline diuresis, and his creatinine levels improved.

Conclusions:
ATN from rhabdomyolysis is a rare complication of compartment syndrome that requires high suspicion and timely treatment to prevent further nephrotoxicity and the resultant increases in mortality. It is imperative for orthopedic surgeons to be aware of this potential complication.
Superior Capsular Reconstruction for Massive Rotator Cuff Tears
Authors: Galvin Joseph W. , Kenney Raymond , Curry Emily J. , Parada Stephen A. , Eichinger Josef K. , Voloshin Ilya , Li Xinning 
Published: June 2019

» A massive rotator cuff tear is defined as a tear involving >2 tendons or >5 cm of retraction.» Superior capsular reconstruction is done with either a folded fascia lata autograft (6 to 8 mm in thickness) or acellular dermal allograft (3 to 4 mm in thickness). The graft is secured arthroscopically with anchors on the superior glenoid rim and multiple anchors on the humeral head with use of a transosseous-equivalent repair technique.» Superior capsular reconstruction is indicated for younger patients with massive and irreparable rotator cuff tears involving the supraspinatus and infraspinatus with minimal arthritis, intact subscapularis, and a functional deltoid. Contraindications include bone defects, stiffness, and moderate to severe arthropathy.» Arthroscopic superior capsular reconstruction with fascia lata autograft or humeral dermal allograft is a surgical option, with multiple studies showing statistically significant improvement in short-term outcomes for both pain and function among younger patients with massive irreparable rotator cuff tears. The long-term clinical effectiveness and value have yet to be determined.» Biomechanical data suggest improved restoration of superior glenohumeral stability with decreased subacromial contact pressures in association with the use of the 8-mm fascia lata graft as compared with the 4-mm acellular humeral dermal allograft. In addition, fascia lata graft has shown less elongation and thinning than humeral dermal graft.» Either fascia lata autograft or humeral dermal allograft may be used clinically for arthroscopic superior capsular reconstruction; however, a graft thickness of at least 3 mm is recommended to decrease the risk of radiographic and clinical failure.» No comprehensive quality-of-life or cost-comparison analyses are available to compare superior capsular reconstruction, reverse total shoulder arthroplasty (rTSA), tendon transfer, and partial rotator cuff repair for the treatment of massive irreparable rotator cuff tears. However, the potential higher cost of superior capsular reconstruction and the lack of long-term clinical outcomes or revision data suggest that either an attempt at repair or primary arthroplasty may be more cost-effective than superior capsular reconstruction.» Long-term outcome data are essential to determine the role of superior capsular reconstruction for young patients with massive irreparable rotator cuff tears.» Superior capsular reconstruction using fascia lata autograft may provide a different biomechanical and biological healing environment compared to acellular dermal allograft. Thus, the clinical outcome data between the 2 graft methods should not be generalized.