bluuebunny/crossref_metadata_2025_split huggingface dataset:
The “combined team” transition clinic model in endocrinology results in high adherence rates and patient satisfaction
Authors: Twito Orit , Shatzman-Steuerman Rachel , Dror Nitzan , Nabriski Dan , Eliakim Alon 
Published: April 2019

AbstractBackgroundA structured transition process for young adults with chronic medical conditions from pediatric to adult clinics is strongly promoted. However, the most appropriate transition model has not yet been determined. This study evaluated the effect of a “combined team” Endocrinology Transition Clinic model, including a joint meeting with the patient and pediatric and adult endocrinologists, regarding medical treatment, adherence to follow-up and patient satisfaction with the process.MethodsClinical and demographic data of patients admitted to the Endocrinology Transition Clinic were collected. The clinical impact of the transition meeting was evaluated based on treatment modifications and patient adherence to follow-up. Patient satisfaction was evaluated using a questionnaire.ResultsFrom September 2014 through November 2018, 107 patients attended the Endocrinology Transition Clinic, 85.0% were females, mean age 19.7 ± 2.2 years (range 16–29), 97.2% were unmarried. The most common endocrine disorders were obesity (41.1%), Hashimoto’s thyroiditis (41.1%) and ovarian hyperandrogenism (38.3%). The Transition Clinic visit modified treatment and/or evaluation for 48 (44.8%) patients. Adherence to follow-up in the adult clinic was 82.9% and was not associated with gender (p = 0.366), ethnicity (p = 0.725), age at transition (p = 0.479) or obesity (p = 0.375). Overall satisfaction reported by 65/85 patients was high (86.8%), although higher among patients who were adherent to follow-up (89.4% vs. 65.6%, p = 0.006).ConclusionsThe “combined team” transition model in endocrinology requires relatively few resources and has considerable clinical impact, high adherence to follow-up and high patient satisfaction rate. Implementing this model at the interface of pediatric and adult endocrinology units, and possibly in other medical fields, is feasible and efficient.
A Likelihood-Free Estimator of Population Structure Bridging Admixture Models and Principal Components Analysis
Authors: Cabreros Irineo , Storey John D 
Published: April 2019

AbstractCharacterizing genetic variation in humans is an important task in statistical genetics, enabling disease-gene mapping in genome-wide association studies (GWAS) and informing studies of human evolutionary history. A common approach to quantifying genetic variation...We introduce a simple and computationally efficient method for fitting the admixture model of genetic population structure, called ALStructure. The strategy of ALStructure is to first estimate the low-dimensional linear subspace of the population admixture components, and then search for a model within this subspace that is consistent with the admixture model’s natural probabilistic constraints. Central to this strategy is the observation that all models belonging to this constrained space of solutions are risk-minimizing and have equal likelihood, rendering any additional optimization unnecessary. The low-dimensional linear subspace is estimated through a recently introduced principal components analysis method that is appropriate for genotype data, thereby providing a solution that has both principal components and probabilistic admixture interpretations. Our approach differs fundamentally from other existing methods for estimating admixture, which aim to fit the admixture model directly by searching for parameters that maximize the likelihood function or the posterior probability. We observe that ALStructure typically outperforms existing methods both in accuracy and computational speed under a wide array of simulated and real human genotype datasets. Throughout this work, we emphasize that the admixture model is a special case of a much broader class of models for which algorithms similar to ALStructure may be successfully employed.
Client Awareness and Perception of CSR Activities in Islamic and Conventional Banks: a Survey in Bahrain
Authors: Al-Hadrami Abdulla Hamzah , Hidayat Sutan Emir 
Published: April 2019

Corporate social responsibility (CSR) is considered one of the highest priorities of corporations and is one of the hottest topics in academic research, that several researchers found positive significant relationship between company’s performance and CSR activities. The current study aims to explore the clients’ awareness and perception of CSR in Islamic and conventional banks across Bahrain. The study surveyed 305 clients, 175 from the Islamic banks, and 130 from the conventional banks. The results indicated that the clients of Islamic banks are more aware of their banks CSR activities than the clients of the conventional banks. With regard to the clients’ perception of their banks CSR, it has been found that Islamic banks clients have more positive perception about their banks’ CSR than those of the conventional banks. Additionally, the results indicated that there are statistically significant differences in the clients’ awareness and perception of banks’ CSR activities when the clients are grouped according to age, income, education, and bank type.
Servant Leadership Improves the Knowledge Sharing Behavior of Employees: A Case of Higher Education Sector in Pakistan
Authors: Amin Hina , Ahmed Farhan , Soomro Riaz Hussain 
Published: April 2019

The purpose of this paper is to investigate the role of servant leadership in organizations in Karachi and to investigate the level of knowledge sharing (KS) behavior among employees. This study will explore the key qualities of servant leadership to be extracted from the literature and relate each trait with KS tendency. The study would base on quantitative design & followed post positivism research paradigm. The primary data has been collected from respondents of specific industry through survey questionnaire. Multiple regression has been used for model testing. The findings of the study enlightened benefits of knowledge sharing behavior that can be prevailed through servant leadership model and encourage employees’ participation. Four traits of servant leadership which are altruistic calling, emotional healing persuasive mapping and organizational stewardship has impact on knowledge sharing behavior of employees at workplace. The findings of the study will be beneficial for the managers and employees of the organization to understand the importance of servant leadership & its application in enterprises.
Antioxidant Activity of Extract from Ultrasonic-Assisted Extraction of Durian Peels
Authors: Kunarto Bambang , Sani Ely Yuniarti 
Published: April 2019

The increase in durian production results in the accumulation of durian peel waste. The bioactive component of durian peel has the potential to be used as an antioxidant. Thus, there is a need to carry out an extraction process to obtain bioactive compounds from durian peel. However, conventional extraction methods cause damage to phenolic compounds due to oxidation, hydrolysis and ionization reactions during the extraction process. Therefore, durian peel extraction was carried out using ultrasonic assisted extraction method (UAE) in this study. The purpose of this study was to investigate the effect of varying ratios of durian peel to ethanol solvents and extraction time on the yield, total phenolics content, total flavonoids content and antioxidant activity. The results of the research data were analyzed using a two-factor completely randomized design, which included variations of the ratio of durian peel to ethanol solvents and extraction time The Duncan’s New Multiple Range Test (DNMRT) was carried out as a follow up test to determine the differences in each treatment at a significance level of 0.05. The results showed that the best treatment for peel extraction using ultrasonic assisted extraction was a 1: 9 ratio of durian peel to ethanol at an extraction time of 20 minutes. The extraction of durian peel under this condition gave the highest yield of 12.77 ± 0.16%, antioxidant activity (IC50) of 38.33 ± 0.12 ppm, total phenolic content of 63.30 ± 0.08 mgGAE / g and total flavonoids content of 47.53 ± 0.48 mgQE / g. In addition, total phenolics content and total flavonoid content showed a strong correlation to the antioxidant activity of durian peel extract.
Role of adipokines, oxidative stress, and endotoxins in the pathogenesis of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Authors: M. Pallavi , M. Suchitra M. , Sachan Alok , Y. Lakshmi A. , P. V. L. N. Srinivasa Rao 
Published: April 2019

Background: Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation and oxidative stress, implicated in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Present study aimed to assess the role of adipokines, oxidative stress, and endotoxins in the pathogenesis of NAFLD in T2DM.Methods: Present cross-sectional observational study included healthy controls (n=50; group 1); T2DM patients without NAFLD (n=50; group 2), T2DM patients with NAFLD (n=50; group 3). Study subjects were age and gender matched.Results: Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CRP), endotoxin, malondialdehyde (MDA) were significantly elevated and adiponectin, ferric reducing ability of plasma (FRAP), and glutathione (GSH) were significantly lower (p<0.001) in T2DM patients with NAFLD when compared to T2DM patients without NAFLD and controls. Endotoxin showed significant positive correlation with TNF-α (r=0.304; p<0.001), hs-CRP (r=0.193; p=0.018), and MDA (r=0.420; p<0.001), and significant negative correlation with adiponectin (r=-0.406; p<0.001). TNF-α and IL-6 showed significant positive correlation with MDA (r=0.526; p<0.001, r=0.229; p=0.005) and significant negative correlation with adiponectin (r=-0.396; p<0.001, r=-0.318; p<0.001), FRAP (r=-0.418; p<00.001, r=-0.170; p=0.038), and GSH (r=-0.353; p<0.001, r=-0.301; p<0.001).Conclusions: Authors observed elevated endotoxin, oxidative stress, inflammation and lower adiponectin levels in T2DM subjects compared to controls. These changes were more pronounced in T2DM with NAFLD when compared to T2DM without NAFLD. Lower adiponectin levels were found to be a better predictor of NALFD in T2DM and is associated with oxidative stress and systemic inflammation.
Diagnostic outcome of fine needle aspiration cytology in 400 cases of head and neck masses in tertiary care center
Authors: Patel Alpesh V. , Patel Nehal R. , Vadher Payal R. , Kakadia Manali B. 
Published: April 2019

<p class="abstract"><strong>Background:</strong> The objective of the study was to identify various lesions of neck swellings and to study their distributions according<strong> </strong>to age, sex and site and to find out distribution of malignant, inflammatory and infective lesions in neck swellings.</p><p class="abstract"><strong>Methods:</strong> The prospective study was conducted in the department of ENT, SCL General<strong> </strong>Hospital, NHL MMC, Saraspur, Ahmedabad from July 2014 to July 2016. All indoor and outdoor 400 patients of SCL hospital presenting with palpable head and neck swellings were referred to the cytology section at SCL hospital for FNAC and included in present study. </p><p class="abstract"><strong>Results:</strong> In our study out of 400 cases, lymph nodes constituted 276 cases with female<strong> </strong>preponderance. Among the inflammatory lesions, commonest lesion was tuberculosis which comprised of 147 cases followed by 64 cases of reactive lymphadenitis. In thyroid lesions the male: female ratio was 1:18, with maximum incidence in age group of 20-50 years. Total 95 cases were observed, out of which benign thyroid lesions (Bethesda grade II) were most common (92.63%). Salivary gland comprised of 11 cases, Out of 10 benign neoplastic lesions, 9 cases of pleomorphic adenoma and 1 cases of Warthin’s tumor were found.</p><p class="abstract"><strong>Conclusions:</strong> FNAC is a very simple and expeditious procedure which can be carried out without much<strong> </strong>problem. It reduces the necessities to perform excisions biopsy in many cases. Thus, FNAC can be recommended as a first line of investigation in the diagnosis of neck swellings and can be adopted as an outpatient procedure, thus reducing the cost and time of hospitalization.</p>
Decoding vestibular migraine for easier diagnosis
Authors: Vazhipokkil Anoop C. , Shenoy Ashwini 
Published: April 2019

<p class="abstract"><strong>Background:</strong> Due to the absence of a unified set of diagnostic criteria, vestibular migraine is always an underdiagnosed entity. This study was undertaken to find specific pointers in the diagnostic protocol which can help in diagnosing vestibular migraine and also to assess our treatment module for vestibular migraine.</p><p class="abstract"><strong>Methods:</strong> An elaborate proforma was prepared for evaluating each patient at our vertigo clinic for a time period of two years. A detailed history is followed by general examination, ENT examination, specific tests for eyes, tests for vestibulospinal tract, and also a few more tests such as Doppler, pure tone audiogram, ECHO etc. when the diagnosis was in doubt. A total of 206 patients were evaluated. Vestibular migraine cases were started on our drug regimen of Tab flunarizine once daily and subjected two follow ups (at 4 weeks and 12 weeks). </p><p class="abstract"><strong>Results:</strong> Total of 20 patients (9.7%) diagnosed as vestibular migraine. There was a slight preponderance to female population. A positive history of recurrent headache and neck pain were definitive clinchers in diagnosing vestibular migraine. All 20 patients had alleviation of symptoms with regards to severity and frequency of episodes.</p><p class="abstract"><strong>Conclusions:</strong> Detailed history and elaborate vestibular examination alone is necessary for diagnosing vestibular migraine. Flunarizine regimen for a period of 3 months is found to be effective in relieving the symptoms. Adjuvant vestibular rehabilitation exercises mandatory for total alleviation of symptoms.</p>
CT scan vs nasal endoscopy findings in the diagnosis of chronic rhinosinusitis: our experience
Authors: Baruah Shruti , Vyas Pratibha , Srivastava Arpit 
Published: April 2019

<p class="abstract"><strong>Background:</strong> Diagnostic nasal endoscopy and CT imaging are both widely used essential diagnostic tools for chronic rhinosinusitis (CRS). This study analyses their individual roles in the management of CRS as well as the degree of correlation between the two.</p><p class="abstract"><strong>Methods:</strong> A prospective observational comparative study was conducted in the Department of Otorhinolaryngology, Mahatma Gandhi Hospital, Jaipur from January, 2017 to June, 2018 on a sample size of 201 patients diagnosed with chronic rhinosinusitis, as per AAOHNS guidelines. DNE and CT PNS were done for all patients enrolled in the study, the findings of each were correlated and their individual sensitivity and specificity for each variable was calculated. </p><p class="abstract"><strong>Results:</strong> On Comparing CT findings with diagnostic nasal endoscopic findings, Polyps were seen in 91 patients’ CT scans as opposed to 124 on DNE. B/L Polyps on CT imaging vs bilateral ethmoidal polyps visualized during DNE revealed a highly significant “P” value; whereas for antrochoanal polyps or unilateral polyps there was no significant difference. Maxillary sinus involvement is the most commonly observed finding in CT scan of PNS in CRS while deviated nasal septum is the most common finding on a diagnostic nasal endoscopy, seen in 60.7%. For anatomical variants like concha bullosa and paradoxical middle turbinate, no significant difference was seen.</p><p class="abstract"><strong>Conclusions:</strong> CT scans and DNE are both key pre-operative diagnostic tools for patients of CRS and both are complementary to each other in detecting type and extent of pathology.</p>
DCP vs LCDCP in forearm fractures: a comparative study of functional outcomes
Authors: D’souza Aaron R. , Krishna Vamsi M. , Eswaran Kaushik S. , Kumar Shailesh 
Published: April 2019

<p class="abstract"><strong>Background:</strong> Forearm fractures in general, and diaphyseal fractures in specific, are one of the most common fractures which accounts for about 31% of upper limb fractures seen in emergency. Early reduction and fixation is necessary in order to restore the function of forearm so as to be able to carry out their daily activities. The objective of this study was to compare the functional outcomes of forearm fractures fixed with DCP and LC DCP.</p><p class="abstract"><strong>Methods:</strong> The present study was a hospital based study, and a prospective, comparative study. A total of 40 patients with fracture of both bones forearm were taken up for the study, and randomly divided into 2 groups of 20 patients each. They were followed up for a period of 1 year.<strong></strong></p><p class="abstract"><strong>Results:</strong> The majority of patients were males (31 males and 9 females), involving age group 21-30. The left side was more common than right in both groups. The site of fracture was middle one-third of forearm in both groups (60% in group A and 65% in group B). The time for union was on average 4 weeks for LC DCP and DCP. ROM was full in 85% in DCP group and 90% in LC DCP group. Overall results were comparable in both groups. Excellent in 34 cases (18 in LC DCP, 16 in DCP), satisfactory in 5 cases (2 in LC DCP, 3 in DCP) and unsatisfactory in one case treated with DCP.</p><p class="abstract"><strong>Conclusions:</strong> LC DCP provides slightly better functional outcome in terms of time taken for union, early mobilisation and range of motion. However, it is more expensive than DCP.</p><p class="abstract"> </p><p> </p>
The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis
Authors: Nazar Elham , Khatami Fatemeh , Saffar Hiva , Tavangar Seyed Mohammad 
Published: April 2019

Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key function both in familial and non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations can have resulted in genetic and epigenetic changes like histone hypermethylation. These properties can lead to succinate-mediated inhibition of α-ketoglutarate-dependent dioxygenases. So hypoxic conditions can generate subsequent neoplastic transformation, and in this review, we are presenting the role of SDHx in several malignancies.
Determining Model for Maximum Blood Request (MSBOS) for Surgery: An Elective Surgery in Imam Ali Hospital, Zahedan, Iran
Authors: Hashemi Seyed Mehdi , Soleimanzadeh Mousavi Seyed Hossein , Tavakolikia Zeinab 
Published: April 2019

Background: Nowadays, excessive blood intake is one of the most common problems in educational hospitals, causing issues such as the lack of proper distribution of blood products among centres, increases in costs and blood bank workloads. So, programs such as a Maximum Surgical Blood Ordering Schedule (MSBOS) were introduced to design a blood ordering schedule, which is a guide to normal transfusion needs for common surgical procedures.
Materials and Methods: This study was a descriptive cross-sectional study. The sampling method was designed and distributed among all sectors of the hospital. Each sector according to the demand for blood and cross-matched transfused units entered the rate of wasted and unused blood bags on the related forms. This study was performed on 1568 patients, of whom 562 (35/84%) were given blood transfusions.
Results: The aim of this study was to determine the pattern for the maximum surgical blood order schedule (MSBOS) for elective surgical procedures/in elective surgery cases in Imam Ali Hospital, Zahedan. This study was performed on 1568 patients, of whom 562 (35/84%) were given blood transfusions. The mean C/T ratio was 1.61 ± 0.99, the mean TI was 0.61 ± 0.38, and the mean T index was 36.4 ± 30.16%.
Conclusion: In general, only 55% of the blood units were used. Hernia surgery, thyroidectomy, and patients with renal problems had the greatest number of wasted units. Therefore, according to the results, indications of blood donation should be made correctly by health care personnel in all patients requiring a blood transfusion, and if there is an increased number of indications, packed cells are requested.
Poultry: A receptacle for non-typhoidal Salmonellae and antimicrobial resistance
Authors: Bangera Sohan Rodney , Umakanth Shashikiran , Chowdhury Goutam , Narayan Saha Rudra , Mukhopadhyay Asish K. , Ballal Mamatha 
Published: April 2019

Background and Objectives: Non-typhoidal Salmonellosis, a zoonotic infection associated with acute gastroenteritis is caused by non-typhoidal salmonellae (NTS). The study was carried out to determine the prevalence of NTS serovars and their antimicrobial resistance along with the presence of the virulence gene (invA gene) in poultry samples.
Materials and Methods: This is a prospective cross-sectional study carried out at the Enteric Diseases Division, Kasturba Medical College, Manipal, South India from January 2016– December 2017. Poultry samples were collected randomly from two local poultry farms in Udupi district and processed following CDC standard protocol.
Results: From the 396 poultry meat samples, intestinal contents and faecal samples collected, 58 NTS serovars were isolated showing a prevalence of 14.64%. Salmonella Infantis, 43.1%, 25/58 was the commonest serovar. Resistance to ciprofloxacin
72.41%, ampicillin 32.8%, gentamicin 17.24%, cotrimoxazole 29.31% and amoxicillin-clavulanic acid 6.9% was observed.
The invA gene was detected in 43 NTS isolates (74.13%).
Conclusion: Poultry sources are recognized as a significant cause for non-typhoidal salmonellosis. Therefore, hygienic measures should be initiated to reduce the contamination of meat and poultry products with virulent strains of Salmonella that are of public health significance.
PENGARUH HOUSE INDEX DAN MAYA INDEX TERHADAP KEJADIAN DEMAM BERDARAH DENGUE DI KECAMATAN GROGOL KABUPATEN SUKOHARJO MENGGUNAKAN GEOGRAPHIC INFORMATION SYSTEM (GIS)
Authors: Maharani Nine Elissa , Rohsulina Pranichayudha 
Published: April 2019

Dengue fever is an important public health problem in indonesia, in the year 2014 the number of death due to dengue fever in Indonesia 903 people from 99499 cases. Sukoharjo district is one of the bloody endemic distrric in central java. In eradicating dengue fever, the larva survey used is a visual method using the entomology indicator, the house index and maya index. This study aims to determine the effect of house index and maya index on the incidence of dengue fever in Grogol district of Sukoharjo using geographic information system (GIS). The research method used is an analytical survey wuth cross sectional approach. The result of the study showed a maya index effect on the incidence of dengue fever in Grogol district of Sukoharjo (p value 0,00), there is no effect of house index on the incidence of dengue fever in Grogol District of Sukoharjo (p value 0,87).