bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ischemic Preconditioning Enhances Performance and Erythrocyte Deformability of Responders
Authors: Tomschi Fabian , Niemann David , Bloch Wilhelm , Predel Hans-Georg , Grau Marijke 
Published: June 2018

AbstractThis pilot study aimed to evaluate the differential effects of a remote ischemic preconditioning (rIPC) manoeuvre on performance and red blood cell (RBC) deformability compared to a sham control and a placebo setting. Ten male subjects performed three test settings in a single-blind, crossover, and randomized control design. All settings started with 20 min of rest and were followed by 4 cycles of occlusion/reperfusion consisting of 5 min each. During rIPC and placebo, the cuff pressure was inflated to 200 mmHg and 120 mmHg, respectively. During the sham control setting, 10 mmHg pressure was applied. All tests were followed by a cycle exercise with lactate diagnostics. Power at 2 and 4 mmol/l lactate thresholds were calculated. RBC deformability was measured before and after the respective manoeuvre. Results showed that no effect resulted from any manoeuvre on performance values or RBC deformability. But 6 subjects showed a higher power at the 2 mmol/l threshold, and 5 subjects exerted higher power at the 4 mmol/l threshold when the rIPC manoeuvre preceded the exercise. In these responsive subjects, RBC deformability also improved. Hence, rIPC effects are much influenced by the subjects’ responsiveness, and improved RBC deformability might contribute to enhanced performance in responsive subjects.
Prevention of Thromboplastin-induced Thrombosis in Rabbits by Means of Plasmin
Authors: Storm Ole 
Published: June 2018

Summary1. By administration to rabbits of plasmin produced by activation of human plasminogen with human urine activator, fibrinolysis in the blood was obtained without observable side effects.2. A single injection of plasmin protects the animals from a fatal intra vascular coagulation produced by a subsequent thromboplastin administration. Among the control animals treated with inactive plasmin, ⅔ of the animals died from pulmonary thrombosis or massive intracardial coagulation of the blood.
Metamorphose visqueuse des Plaquettes et Formation du Clou hémostatique
Authors: Hugues Jean 
Published: June 2018

RésuméL’action locale de trois antihistaminiques sur le développement du clou hémostatique a été étudiée au niveau des vaisseaux microscopiques du mésentère du lapin.La Téphorine et le Diparcol inhibent le développement du thrombus pla-quettaire; le Multergan est sans action.L’action antihémostatique des deux premiers antihistaminiques doit être rapprochées de l’entrave qu’ils apportent à la métamorphose visqueuse des plaquettes. Cette dernière parait indispensable à l’agglutination réciproque des thrombocytes extravasés au cours du développement du clou hémostatique.Par ailleurs, l’action des anticoagulants classiques sur l’élaboration d’un thrombus plaquettaire dépend des doses utilisées.Les effets différents dont sont responsables les anticoagulants à fortes doses, les antihistaminiques et les anticoagulants à faible dose, permettent de scinder le développement du clou hémostatique en 3 stades successifs: a) l’agglutination — très précoce — des premières plaquettes extravasées aux lèvres du vaisseau, b) la constitution progressive d’un thrombus plaquettaire volumineux mais perméable, c) l’imperméabilisation de ce thrombus.
A “New” Family with Stuart-Prower Deficiency
Authors: Roos J , van Arkel C , Verloop M. C , Jordan F. L. J 
Published: June 2018

SummaryA description is given of the coagulation disturbances in six patients with a haemorrhagic diathesis due to Stuart-Prower deficiency. Relatives of these patients, if heterozygous for this deficiency, showed no significant haemorrhagic diathesis; in the laboratory, their one-stage “prothrombin” times showed only a slight prolongation. Thromboplastin formation in these relatives was sufficient, but determination of the Stuart-Prower factor revealed lower values. The relatives in question were incapable of giving the same correction of the thromboplastin generation test in their bleeder relatives as normal serum does.The relation between Stuart-Prower deficiency and Christmas factor is discussed.One patient is described who combined heterozygotism for Stuart-Prower deficiency with alcaptonuria.The mode of inheritance of the Stuart-Prower deficiency is discussed.
Agglutination précoce des Plaquettes au cours de la Formation du Clou hémostatique
Authors: Hugues Jean 
Published: June 2018

RésuméAprès section d’un vaisseau microscopique, il se produit un accolement remarquablement rapide de plaquettes à la brêche vasculaire. Cet accolement est visible dans 45% des cas on cours la lère seconde, dans 73% des cas on cours des deux premières secondes.Les hémorragies prolongées (au delà de 10 minutes) ne sont pas nécessairement liées à un trouble de l’accolement précoce des thrombocytes.L’action de nombreux facteurs sur la formation du clou hémostatique a été étudiée. Seuls les anticoagulants à forte dose et mieux encore les injections I.V. lentes de thrombine, entravant la fixation rapide des plaquettes.Le rôle éventuel de processus coagulatifs dans ce phénomène est discuté.
Influence of Dicoumarol Derivatives on Plasma Fibrinolytic System
Authors: Niewiarowska Marta , Wegrzynowicz Zenon 
Published: June 2018

SummaryThe influence of some coumarine derivatives (anticoagulant drugs: pelentan [tromexan], sintrom, marcoumar) on plasma fibrinolytic activity has been investigated. The cases studied included a number of patients with coronary thrombosis treated in long-term anticoagulant therapy and rabbits treated with a single dose of the drug.The anticoagulants have no significant effect either on fibrinogen or plasminogen level. All of the above mentioned drugs cause a prolongation of the euglobulin fibrinolysis time and an increase of the antiplasmin level. These two changes may be correlated to the prolongation of the prothrombin time.The authors suggest that the described phenomena may be useful for biological and clinical evaluation of anticoagulant drugs.
The Mechanism of Fibrinolysis Induced by Bacterial Pyrogens
Authors: Deutsch E , Elsner P , Marschner I ,   with the technical assistance of
Published: June 2018

Summary1. The mechanism of the activation of plasmin in blood after intravenous injection of bacterial pyrogens was studied.2. There was plasmin and an activator present in the spontaneous lytic blood samples. In cases with a high level of plasmin a low amount of plasminogen was found and vice versa.3. There seem to be two mechanisms of activation. In the most cases the activator has the properties of a fibrinokinase. In the other type a fibrinolysokinase was found.4. The resistence of the activator against changes in pH and influence of temperature was studied. It was found that the activator was very resistent at acid pH, and, therefore, it shoud be classified as a stable type activator. In addition to this a small amount of a labile type activator seems to be present.5. Some fibrinolytic activity develops in vitro if the pyrogens are incubated with cell-containing plasma or blood. It is supposed that the leucocytes are involved in the activation mechanism.
Etude de la Recanalisation sous Traitement Anticoagulant des Artères Thrombosées Expérimentalement
Authors: Baeckeland E 
Published: June 2018

RésuméNous avons réalisé des thromboses d’artères fémorales superficielles chez le Lapin selon la technique de Wright et Kubik. Un certain nombre de lapins ont été traités par un dérivé du dicoumarol. Nous avons fait une étude histologique approfondie des vaisseaux thromboséd, prélevés 3 à 40 jours après la thrombose. Sous l’influence de la thérapeutique, nous avons constaté une restauration fonctionnelle rapide de l’artère; un processus de fibrinolyse, au cours des premiers jours, est à l’origine de la reperméabilisation.
Comparative Studies of the Fibrinolytic System of Sera of Various Vertebrates
Authors: Niewiarowski Stefan , Latallo Zbigniew 
Published: June 2018

Summary1. Comparative studies have been performed on the fibrinolytic system of sera of 18 vertebrates: man, monkey, dog, cat, ox, horse, ram, pig, rabbit, mouse, rat, hamster, guinea-pig, hen, duck, turkey, frog, fish.2. Spontaneously active plasmin in a considerable amount has been found only in guinea-pig euglobulin.3. The euglobulins from human, monkey, cat and dog sera can be activated by SK and by SKHP mixture.4. The euglobulin from hamster, rat, mouse, rabbit, bovine, horse, pig and ram sera can be activated by SKHP but not by SK.5. The euglobulins of lower vertebrates species cannot be activated by neither SK nor SKHP to any considerable value.6. The activation of fibrinolytic system runs parallel with the activation of proteolysis in human, bovine and guinea-pig euglobulin.7. The proactivator activity has been found in the species of human, monkey, dog and cat.8. Streptokinase activated human plasmin (SKHP) has been inhibited by most of the examined animals sera except of the human, monkey, dog and cat sera.9. It has been found that in the course of purification bovine plasminogen acquires the ability to be activated by SK. An inhibitor of activation occuring in bovine serum and euglobulin is probably removed by purification of plasminogen.10. The activation of plasmin in guinea-pig serum has been studied, it was found that spontaneous fibrinolytic activity generates slowly in guinea-pig euglobulin and reaches a maximum after 24 hours. Guinea-pig serum and shortly precipitated euglobulin could be activated by SKHP mixture only.11. Several possible explanations of the different behaviour of fibrinolytic systems in various animals have been discussed.
Steigerung der endogenen Antithrombokinase-Produktion bei Lungenembolie und Myokardinfarkt
Authors: Kovács Erwin 
Published: June 2018

ZusammenfassungWir haben über die Gerinnungsverhältnisse bei drei Fällen von Lungenembolie und einem Fall von Myokardinfarkt berichtet, in denen wir eine pathologische Vermehrung endogener Antithrombokinase beobachtet haben. Die im Laufe der thromboembolischen Erkrankung auftretende Vermehrung des Anti-koagulans war während 2 bis 7 Tagen im Blute der Kranken nachweisbar. Bei zwei Kranken traten spontan Blutungen auf. Untersuchungen über die Art-spezifität und einige physiko-chemische Eigenschaften des endogenen Anti-koagulans werden kurz referiert. Außerdem wurden einige Annahmen über mögliche Ursachen der Antikoagulantienvermehrung diskutiert: 1. Die Antithrombokinase entstammt aus nekrotischen Geweben. 2. Die Antithromboplastinämie wird durch Störung im Kompensationsmechanismus (Überkompensation) verursacht. 3. Die Antikoagulantienvermehrung setzt auf Antigenwir-kung ein. Endlich betonten wir die praktische Bedeutung der Antikoagulantienvermehrung.
Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the “Hartel's Route”
Authors: Casolla Barbara , Candela Serena , Ciacciarelli Antonio , Ciolli Ludovico , Romano Andrea , Acqui Michele , Cox Maria , Sette Giuliano , Orzi Francesco 
Published: June 2018

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. We reached the diagnosis by mean of a nonstandard, mini-invasive, transforamen ovale biopsy of the intracranial lesion (Hartel's route).The nature of the renal mass was determined ex juvantibus. The patient responded to the polichemotherapy with a complete regression of the intracranial lesion and of the renal mass evaluated by computed tomography and total body positron emission tomography scans. We, therefore, confirmed the DLBCL location in the right kidney. Over 4 years of follow-up, the patient has showed a complete remission of the disease. In this report, we emphasize the importance of biopsy in case of Garcin syndrome.
The Relationship of Assisted Reproductive Technology on Perinatal Outcomes in Triplet Gestations
Authors: Shah Jaimin , Roman Tania , Viteri Oscar , Haidar Ziad , Ontiveros Alejandra , Sibai Baha 
Published: June 2018

Objective To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception.
Study Design Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death.
Results There were 381 triplets (127 women) of which 89 patients conceived via ART and 38 patients spontaneously. Women with ART were more likely to be older, Caucasian, married, nulliparous, have higher level of education, and develop pre-eclampsia. Spontaneously conceived triplets were more likely to delivery at an earlier gestation (31.2 ± 3.5 vs 32.8 ± 2.7 weeks) (p = 0.009) with a lower birth weight (p < 0.001). After adjusting for confounders, no differences were noted in culture proven sepsis, perinatal death, CNM, respiratory distress syndrome, or Apgar score < 7 at 5 minutes. All remaining perinatal outcomes were similar.
Conclusion Triplets conceived by ART had similar perinatal outcomes compared with spontaneously conceived triplets.
Actuación del cirujano ante una parálisis braquial obstétrica en los 2-3 primeros años de edad
Authors: Pradilla Pilar 
Published: June 2018

ResumenLa parálisis braquial obstétrica (PBO) es una grave entidad clínica con muchas cuestiones por resolver. Se desconocen los verdaderos factores de riesgo, y aunque la cirugía nerviosa ha mejorado su técnica y las secuelas se previenen con mayor seguridad que hace unos años, el resultado no es el deseado, pues la incidencia de la enfermedad no ha variado y con la cirugía sigue habiendo un porcentaje alto de fracasos en lesiones extensas o que afecten a la mano. En este artículo, se revisará el tratamiento actual en niños con PBO menores de 2–3 años. Se analizarán las técnicas más actuales como son las transferencias nerviosas, la artroscopia de hombro o el uso de la toxina botulínica.
E-Zigaretten: gesundheitliche Bewertung und potenzieller Nutzen für Raucher
Authors: Schaller K. , Mons U. 
Published: June 2018

ZusammenfassungIn E-Zigaretten wird eine aromatisierte Flüssigkeit erhitzt, und der Konsument inhaliert das dabei entstehende Aerosol. Die große Vielfalt der E-Zigaretten und Liquids erschwert die Abschätzung der gesundheitlichen Auswirkungen der verschiedenen Produkte. Die Inhaltsstoffe der Liquids sind – abgesehen von Nikotin – für die orale und dermale Aufnahme unbedenklich, zu den gesundheitlichen Auswirkungen chronischer Inhalation fehlen jedoch toxikologische Daten. Studien haben im E-Zigaretten-Aerosol verschiedene gesundheitsschädliche Substanzen nachgewiesen, darunter auch Kanzerogene, allerdings in niedrigerer Konzentration als in Tabakrauch. Die vorliegenden Studien deuten darauf hin, dass E-Zigaretten-Konsum zu kurzfristigen Gesundheitseffekten wie entzündlichen Reaktionen in der Lunge führt. In Tier- und Zellversuchen zeigte E-Zigaretten-Aerosol gesundheitsschädliche Effekte wie Zytotoxizität, verstärkte Infiltration von Entzündungszellen und entzündungsfördernden Zytokinen, erhöhten oxidativen Stress und moderate Entzündung.Sehr wahrscheinlich ist der E-Zigaretten-Konsum im Vergleich zum Tabakrauchen weniger schädlich, aufgrund fehlender Studien zu langfristigen Gesundheitsgefahren kann das Ausmaß der Schadensminderung jedoch nicht quantifiziert werden. Zwar verwenden Raucher E-Zigaretten oftmals, um mit dem Rauchen aufzuhören, aber derzeit sind die Produkte nicht als Hilfsmittel zur Tabakentwöhnung zugelassen. Da E-Zigaretten-Aerosol eine neue Quelle für die Belastung der Raumluft ist, ist davon auszugehen, dass es für im Raum anwesende Nichtkonsumenten eine Gesundheitsgefährdung bedeutet, insbesondere für vulnerable Personengruppen wie Kinder oder Menschen mit Gesundheitsproblemen. Auf die öffentliche Gesundheit können sich E-Zigaretten positiv auswirken, wenn viele Raucher vollständig vom Tabakrauchen auf E-Zigaretten-Konsum umsteigen und langfristig auch diesen einstellen, und wenn gleichzeitig negative Effekte (wie steigender Konsum unter Jugendlichen) begrenzt bleiben.
PiggyBac-based screening identifiedBEM4as a suppressor to rescue growth defects in och1-disrupted yeast cells
Authors: Mutumwinka Diane , Zhao Shen-Bao , Liu Yi-Shi , Mensah Emmanuel Osei , Gao Xiao-Dong , Fujita Morihisa 
Published: June 2018

ABSTRACTGlycoengineered yeast cells, which express human-compatible glycan structures, are particularly attractive host cells to produce therapeutic glycoproteins. Disruption of OCH1 gene, which encodes an α-1,6-mannosyltransferase required for mannan-type N-glycan formation, is essential for the elimination of yeast-specific N-glycan structures. However, the gene disruption causes cell wall defects leading to growth defects. Here, we tried to identify factors to rescue the growth defects of och1Δ cells by in vivo mutagenesis using piggyBac (PB)-based transposon. We isolated a mutant strain, named 121, which could grow faster than parental och1Δ cells. The PB element was introduced into the promoter region of BEM4 gene and upregulated the BEM4 expression. Overexpression of BEM4 suppressed growth defects in och1Δ cells. The slow grow phenotypes were partially rescued by expression of Rho1p, whose function is regulated by Bem4p. Our results indicate that BEM4 would be useful to produce therapeutic proteins in glycoengineered yeast without the growth defects.
What Is Successful Aging? A Psychometric Validation Study of Different Construct Definitions
Authors: Kleineidam Luca , Thoma Myriam V , Maercker Andreas , Bickel Horst , Mösch Edelgard , Hajek André , König Hans-Helmut , Eisele Marion , Mallon Tina , Luck Tobias , Röhr Susanne , Weyerer Siegfried , Werle Jochen , Pentzek Michael , Fuchs Angela , Wiese Birgitt , Mamone Silke , Scherer Martin , Maier Wolfgang , Riedel-Heller Steffi G , Wagner, Michael 
Published: June 2018

Abstract

Background and Objectives
We examined the validity of 5 successful aging (SA) operationalizations that assessed different facets of the SA construct (cognitive and physical health and disability; well-being; social engagement).

Research Design and Methods
A total of 2,478 participants (mean age = 82.5 years, standard deviation [SD] = 3.47) were studied. We used confirmatory factor analysis to investigate the relationships between facets and to determine the convergent validity as well as short-term (1.5 years) and long-term (4.5 years) predictive validity of the 5 SA operationalizations for measures of quality of life (QoL) and objective health outcomes.

Results
A general SA operationalization that included all SA facets but also allowed differences between them showed the best model fit and construct validity. A biomedical operationalization of SA that excluded either the well-being or the social engagement facet showed lower convergent and predictive validity for subjective measures (e.g., QoL) but higher associations with objective measures (e.g., health). A purely psychosocial SA operationalization that excluded the physiological facet did not allow good prediction of objective health outcomes.

Discussion and Implications
Our results suggest that a well-balanced SA operationalization should include measures assessing health, disability, well-being, and social engagement.
AMBER: Assessment of Metagenome BinnERs
Authors: Meyer Fernando , Hofmann Peter , Belmann Peter , Garrido-Oter Ruben , Fritz Adrian , Sczyrba Alexander , McHardy Alice C 
Published: June 2018

Abstract
Reconstructing the genomes of microbial community members is key to the interpretation of shotgun metagenome samples. Genome binning programs deconvolute reads or assembled contigs of such samples into individual bins. However, assessing their quality is difficult due to the lack of evaluation software and standardized metrics. Here, we present Assessment of Metagenome BinnERs (AMBER), an evaluation package for the comparative assessment of genome reconstructions from metagenome benchmark datasets. It calculates the performance metrics and comparative visualizations used in the first benchmarking challenge of the initiative for the Critical Assessment of Metagenome Interpretation (CAMI). As an application, we show the outputs of AMBER for 11 binning programs on two CAMI benchmark datasets. AMBER is implemented in Python and available under the Apache 2.0 license on GitHub.
Semibricks
Authors: Asai Sota 
Published: June 2018

AbstractIn representation theory of finite-dimensional algebras, (semi)bricks are a generalization of (semi)simple modules, and they have long been studied. The aim of this paper is to study semibricks from the point of view of $\tau $-tilting theory. We construct canonical bijections between the set of support $\tau $-tilting modules, the set of semibricks satisfying a certain finiteness condition, and the set of 2-term simple-minded collections. In particular, we unify Koenig–Yang bijections and Ingalls–Thomas bijections generalized by Marks–Št’ovíček, which involve several important notions in the derived categories and the module categories. We also investigate connections between our results and two kinds of reduction theorems of $\tau $-rigid modules by Jasso and Eisele–Janssens–Raedschelders. Moreover, we study semibricks over Nakayama algebras and tilted algebras in detail as examples.
Interrogating the ‘Dignity’ Argument for Mandatory Retirement: An Undignified Development?
Authors: Blackham Alysia 
Published: June 2018

Abstract
Human dignity is often cited as a justification and foundation for equality law. However, it is also used in some contexts to justify detracting from equal treatment, including in relation to mandatory retirement ages in the UK. Drawing on interdisciplinary scholarship from legal theory and industrial relations, this article argues case law on retirement ages adopts a limited approach to the notion of ‘dignity’, which is grounded in age stereotypes. It considers how a re-conceptualisation of ‘dignity’ might inform the future development of the law on retirement ages and proposes alternative ways to secure individual dignity in employment that do not depend on mandatory retirement ages.
T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans
Authors: Speranza Emily , Ruibal Paula , Port Julia R , Feng Feng , Burkhardt Lia , Grundhoff Adam , Günther Stephan , Oestereich Lisa , Hiscox Julian A , Connor John H , Muñoz-Fontela César 
Published: June 2018

Abstract
Differences in T-cell phenotype, particularly the expression of markers of T-cell homeostasis, have been observed in fatal and nonfatal Ebola virus disease (EVD). However, the relationship between these markers with T-cell function and virus clearance during EVD is poorly understood. To gain biological insight into the role of T cells during EVD, combined transcriptomics and T-cell receptor sequencing was used to profile blood samples from fatal and nonfatal EVD patients from the recent West African EVD epidemic. Fatal EVD was characterized by strong T-cell activation and increased abundance of T-cell inhibitory molecules. However, the early T-cell response was oligoclonal and did not result in viral clearance. In contrast, survivors mounted highly diverse T-cell responses, maintained low levels of T-cell inhibitors, and cleared Ebola virus. Our findings highlight the importance of T-cell immunity in surviving EVD and strengthen the foundation for further research on targeting of the dendritic cell-T cell interface for postexposure immunotherapy.