bluuebunny/crossref_metadata_2025_split huggingface dataset:
MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge
Authors: Manchanda Kashish , Kolarova Hana , Kerkenpaß Christina , Mollenhauer Martin , Vitecek Jan , Rudolph Volker , Kubala Lukas , Baldus Stephan , Adam Matti , Klinke Anna 
Published: June 2018

Objective—
The leukocyte heme-enzyme MPO (myeloperoxidase) exerts proinflammatory effects on the vascular system primarily linked to its catalytic properties. Recent studies have shown that MPO, depending on its cationic charge, mediates neutrophil recruitment and activation. Here, we further investigated MPO’s extracatalytic properties and its effect on endothelial glycocalyx (EG) integrity.

Approach and Results—
In vivo staining of murine cremaster muscle vessels with Alcian Blue 8GX provided evidence of an MPO-dependent decrease in anionic charge of the EG. MPO binding to the glycocalyx was further characterized using Chinese hamster ovary cells and its glycosaminoglycan mutants—pgsA-745 (mutant Chinese hamster ovary cells lacking heparan sulfate and chondroitin sulfate glycosaminoglycan) and pgsD-677 (mutant Chinese hamster ovary cells lacking heparan sulfate glycosaminoglycan), which revealed heparan sulfate as the main mediator of MPO binding. Further, EG integrity was assessed in terms of thickness using intravital microscopy of murine cremaster muscle. A significant reduction in EG thickness was observed on infusion of catalytically active MPO, as well as mutant inactive MPO and cationic polymer polylysine. Similar effects were also observed in wild-type mice after a local inflammatory stimulus but not in MPO-knockout mice. The reduction in EG thickness was reversed after removal of vessel-bound MPO, suggesting a possible physical collapse of the EG. Last, experiments with in vivo neutrophil depletion revealed that MPO also induced neutrophil-mediated shedding of the EG core protein, Sdc1 (syndecan-1).

Conclusions—
These findings provide evidence that MPO, via ionic interaction with heparan sulfate side chains, can cause neutrophil-dependent Sdc1 shedding and collapse of the EG structure.
Axisymmetric Balance Dynamics of Tropical Cyclone Intensification and Its Breakdown Revisited
Authors: Smith Roger K. , Montgomery Michael T. , Bui Hai 
Published: June 2018

AbstractThis paper revisits the evolution of an idealized tropical cyclone–like vortex forced by a prescribed distribution of diabatic heating in the context of both inviscid and frictional axisymmetric balance dynamics. Prognostic solutions are presented for a range of heating distributions, which, in most cases, are allowed to contract as the vortex contracts and intensifies. Interest is focused on the kinematic structure and evolution of the secondary circulation in physical space and on the development of regions of symmetric and static instability. The solutions are prolonged beyond the onset of unstable regions by regularizing the Sawyer–Eliassen equation in these regions, but for reasons discussed, the model ultimately breaks down. The intensification rate of the vortex is essentially constant up to the time when regions of instability ensue. This result is in contrast to previous suggestions that the rate should increase as the vortex intensifies because the heating becomes progressively more “efficient” when the local inertial stability increases. The solutions provide a context for reexamining the classical axisymmetric paradigm for tropical cyclone intensification in the light of another widely invoked intensification paradigm by Emanuel, which postulates that the air in the eyewall flows upward and outward along sloping absolute angular momentum (M) surfaces after it exits the frictional boundary layer. The conundrum is that the classical mechanism for spinup requires the air above the boundary layer to move inward while materially conserving M. Insight provided by the balance solutions helps to refine ideas for resolving this conundrum.
Nurses’, patients’, and family caregivers’ perceptions of compassionate nursing care
Authors: Tehranineshat Banafsheh , Rakhshan Mahnaz , Torabizadeh Camellia , Fararouei Mohammad 
Published: June 2018

Background: Compassion is the core of nursing care and the basis of ethical codes. Due to the complex and abstract nature of this concept, there is a need for further investigations to explore the meaning and identify compassionate nursing care. Objectives: The purpose of this study was to identify and describe compassionate nursing care based on the experiences of nurses, patients, and family caregivers. Research design: This was a qualitative exploratory study. Data were analyzed using the conventional content analysis method. Participants and research context: Nurses, hospitalized patients, and family caregivers in different educational hospitals in an urban area of Iran were selected from February 2016 to December 2017 using a purposeful sampling method (n = 34). In-depth and semi-structured interviews, focus group interviews, and field notes were used for data collection. Ethical considerations: The study was approved by the University’s Ethics Committee. The participants were informed about the aim and method of the study, reasons for recording the interviews, confidentiality of data, and voluntary nature of participation in this study. Findings: Data from interviews and filed notes were analyzed and classified into three themes: “effective interaction,” “professionalism,” and “continuous comprehensive care.” Discussion and conclusion: Emerged themes of this study involved holistic care in the current literature on nursing with an emphasis on effective interaction and professionalism. Nurses can understand patients’ and family caregivers’ comprehensive needs through interaction skills. In addition, clinical proficiency, maintaining professional ethics’ standards along with holism, and continuity in care are examples of compassionate care. Education program about compassionate care can enhance the quality of nursing care.
Impact of Clinical Guidelines on Revisits After Ambulatory Pediatric Adenotonsillectomy
Authors: Lee Helen H. , Dalesio Nicholas M. , Lo Sasso Anthony T. , Van Cleve William C. 
Published: June 2018

BACKGROUND:
Pediatric adenotonsillectomies are common and carry known risks of potentially severe complications. Complications that require a revisit, to either the emergency department or hospital readmission, increase costs and may be tied to lower reimbursements by federal programs. In 2011 and 2012, recommendations by pediatric and surgical organizations regarding selection of candidates for ambulatory procedures were issued. We hypothesized that guideline-associated changes in practice patterns would lower the odds of revisits. The primary objective of this study was to assess whether the odds of a complication-related revisit decreased after publication of guidelines after accounting for preintervention temporal trends and levels. The secondary objective was to determine whether temporal associations existed between guideline publication and characteristics of the ambulatory surgical population.

METHODS:
This study employs an interrupted time series design to evaluate the longitudinal effects of clinical guidelines on revisits. The outcome was defined as revisits after ambulatory tonsillectomy for privately insured patients. Data were sourced from the Truven Health Analytics MarketScan database, 2008–2015. Revisits were defined by the most prevalent complication types: hemorrhage, dehydration, pain, nausea, respiratory problem, infection, and fever. Time periods were defined by surgeries before, between, and after guidelines publication. Unadjusted odds ratios estimated associations between revisits and clinical covariates. Multivariable logistic regression was used to estimate the impact of guidelines on revisits. Differences in revisit trends among pre-, peri-, and postguideline periods were tested using the Wald test. Results were statistically significant at P < .005.

RESULTS:
A total of 326,993 surgeries met study criteria. The absolute revisit rate increased over time, from 5.9% (95% confidence interval [CI], 5.8–6.0) to 6.7% (95% CI, 6.6–6.9). The proportion of young children declined slightly, from 6.4% to 5.9% (P < .001). The proportion of patients having a tonsillectomy in an ambulatory surgery center increased (16.5%–31%; P < .001), as did the prevalence of obstructive sleep apnea (7.0%–14.0%; P < .001) and sleep-disordered breathing (20.6%–35.0%; P < .001). In a multivariable logistic regression model adjusted for age, sex, comorbidities, and surgical location, odds of a revisit increased during the preguideline period (0.4% increase per month; 95% CI, 0.24%–0.54%; P < .001). This monthly increase did not continue after guidelines (P = .002).

CONCLUSIONS:
While odds of a postoperative revisit did not decline after guideline publication, there was a significant difference in trend between the pre- and postguideline periods. Changes in the ambulatory surgery population also suggest at least partial adherence to guidelines.
Incontinence-associated dermatitis: prevention and treatment. Part 1/2
Authors: Nazarko Linda 
Published: June 2018

When urine or faeces are in contact with the skin for a prolonged period of time, it can become damaged, inflamed, excoriated and infected. This condition is known as incontinence-associated dermatitis (IAD). IAD can cause pain and discomfort and increases the risk of a person developing a pressure ulcer. This article aims to explain how ageing, long-term conditions, impaired functional abilities and urinary and faecal incontinence combine to increase the risks of IAD. It outlines the role of the healthcare assistant in preventing and treating IAD. It emphasises the importance of ensuring that the individual with IAD remains the focus at all times and how meeting the individual's needs and aspirations enables staff to provide sensitive, compassionate care that maintains dignity and privacy.
How to write a good essay: general principles for success
Authors: Stonehouse David 
Published: June 2018

The author has more than 14 years' experience in higher education, supporting students in essay-writing and in marking across all levels up to masters, and as an external examiner. This article examines and highlights the general principles which will assist the student in writing an academic essay. Its aim is to encourage the student and to reduce some of the stress that essay-writing causes. Areas such as maintaining confidentiality, word count, structure, first or third person, reflective accounts, marking criteria, referencing, the range of robust academic sources, plagiarism, spelling and grammar and presentation will be discussed. The most important area of seeking advice from your tutor and reading feedback will be emphasised.
Montréal plus ou moins, 1972: Urban Knowledge Meets Conceptual Attitude
Authors: Sloan Johanne 
Published: June 2018

Abstract
The 1972 exhibition Montréal plus ou moins, curated by the architect Melvin Charney, treated the city’s Museum of Fine Arts as a kind of urban laboratory. Displays created by activist groups as well as artists expressed critical views on Montreal’s urban planning, housing and architectural heritage, while the ambition to reclaim the everyday space of the city resonated with the contemporaneous urban theorizing of Henri Lefebvre. By also featuring performance, give-away artworks, the presentation of documents, and moments of institutional critique, Montréal plus ou moins successfully merged conceptual art strategies with countercultural urban activism.
Cinema of compassion: Andrea Segre and Emmanuel Levinas
Authors: Serra Ilaria 
Published: June 2018

Abstract
This article discusses filmmaker and sociologist Andrea Segre’s film productions, documentaries and fiction films by applying the theoretical filter of Emmanuel Levinas’s Other-centred philosophy. Segre’s filmmaking may exemplify an Italian ‘cinema of compassion’ that responds to and reflects on the cultural shock of seeing the mass approach of the Other – the immigrant. This cinema reflects the unsettling uneasiness of the encounter, while orienting it towards the necessary effect of compassion. Segre was not trained as a filmmaker – a professional in ‘seeing’ the Other – but as a sociologist – a professional in ‘feeling’ and ‘listening to’ the Other. French, Lithuanian-born Jew, Emmanuel Levinas, proposed a philosophy that centres on the ‘constitutive Other’. This concept can convincingly apply to Segre’s films (and much documentary filmmaking) for four main reasons. First, Segre’s movies place the Other at the centre (in the documentary films) or stress it as a dialectic term, a co-protagonist/antagonist (in the fiction films). Second, his movies reject, at the same time as they invite, the identification of Same–Other by respecting the otherness of the Other. Third, they elicit or enact the sentiment of compassion. Finally, these films leave the ‘infinite’ weight of responsibility on the viewers.
Uji Peptida Komersial Hym-248 terhadap Metamorfosis dan Penempelan Planula yang berasal dari Slick (Testing of Commersial Peptide Hym-248 on Metamorphoses and Settlement of Planulae Collected from Slick)
Authors: Wijayanti Diah P , Indrayanti Elis 
Published: June 2018

Metamorfosis dan penempelan merupakan proses yang amat penting dalam siklus hidup koloni karang. Koloni karang hanya akan terbentuk jika larva planula berhasil bermetamorfosis dari larva planktonik menjadi bentik dan menempel pada substrat untuk kemudian bertumbuh menjadi koloni baru. Induktor berperan merangsang metamorfosis dan meningkatkan persentase jumlah zigot yang menempel dan berkembang menjadi koloni baru. Peptida komersial adalah neuropeptida golongan GLWamida yang bertindak sebagai hormon pemicu terjadinya metamorfosis planulae larva. Hasil penelitian menunjukkan, Hym-248, peptida komersial anggota GLWamida, mampu menginduksi metamorfosis dan penempelan planula yang berasal dari slick (kumpulan gamet yang terapung-apung di permukaan laut setelah dilepaskan koloni karang pada peristiwa spawning multispesifik). Slick dikoleksi dari Pulau Sambangan, Kepulauan Karimunjawa saat spawning masal terjadi pada bulan Maret. Seluruh dosis yang dicobakan mampu menginduksi proses metamorfosis dan settlement planula larva setelah planula diinkubasi dalam media yang telah diberi Hym-248. Hasil ini memberi peluang dilakukannya pembenihan larva planulae secara masal untuk keperluan restorasi terumbu karang dan budidaya karang. Kata kunci: metamorfosis, settlement, budidaya karang, Acropora, spawning masal, slick Settlement and metamorphosis, which leads to the formation of primary polyp, are critical steps in the life cycles of corals. Metamorphosis cue is necessary to create an internal trigger to initiate metamorphosis in coral larvae. Neuropeptides which act hormonally to induce metamorphosis, provide a reliable and efficient settlement cue for ex situ larval culture. Here we report that Hym-248, one member of GLWamide peptide can induce metamorphosis of planulae derived from collected slick. Experiments were done in Sambangan Island after March spawning event. The results showed that all applied doses of Hym-248 successfully induced the metamorphosis and settlement of planulae larvae produced from slick. The result of this study showed that coral propagules can be produced faster by applying the commercial peptide as the inducer which leads to mass production of coral propagules for coral culture. Key words: metamorphosis, settlement, coral culture, Acropora, mass-spawning, slick
Nutritional Content of Wild and Cultured Eel (Anguilla bicolor) from Southern Coast of Central Java
Authors: Wijayanti Ima , Setiyorini Endang Sri Susilo 
Published: June 2018

Culture of eel is being pursued in Indonesia, including Central Java,however there has been no data about proximate analysis of both wildand cultured eel. The purpose of this study was to determine the nutritional content of both the wild and the culturedeel Anguilla bicolor from Southern coast of Central Java. Nutritinonal content observed were moisture, protein, fat, ash and carbohydrates content, Vitamin A, Vitamin E and Mineral (Mg, Zn, Ca, Fe). The samples were obtained from Cilacap, Central Java. The data were analyzed by t-Test of Paired Two Sample for Means to determine difference of nutritional content between the wild and the culturedeel. The level of protein, carbohydrates, and Vitamin A were significantly different (P<0.05) between the wild and the cultured one. Whereas the content of water, fat and ash were not significantly different. Furthermore, there was no significant difference the Vitamin E level between the wild and the culturedeel.Mineral levels between the wild and cultured showed significantly different in Mg, Zn and Fe, but not significantly different in Ca. The moisture, protein, carbohydrate, fat, ash, vitamin A and vitamin E content of the wild eel were 62.81%, 16.20%, 1.39%, 17.92%, 1.34%, 3316.38 mg.100g-1, and 0.21% respectively, while the cultured eel were 62.36%, 17.50%, 0.13%, 17.72%, 1.33%, 2068.55 mg.100g-1 and 0.224%, respectively. Magnesium (Mg); Zinc (Zn); Iron (Fe) content of wild and cultured eel respectively 145.35 ppm; 20.9 ppm; 48.08 ppm and 121.97 ppm; 24.44 ppm; 30.99 ppm. Calcium (Ca) content wild and cultured eel were 0.52% and 0.48% respectively. Keywords : Anguilla sp, proximate, vitamin, mineral
Phosphorescence and fluorescence of fibrillar cellulose films
Authors: Grönroos Päivi , Bessonoff Marko , Salminen Kalle , Paltakari Jouni , Kulmala Sakari 
Published: June 2018

Abstract
Celluloses and nanofibrillar celluloses, and the basis of their luminescence are studied. Comparative studies of photoluminescence of birch kraft pulp and microfibrillar and nanofibrillar celluloses manufactured from the same pulp were made with the aim to investigate their luminescence properties. Comparison was made with the earlier literature and the origin of the photoluminescence of these cellulose variants is discussed.
Los inmigrantes chinos y sus descendientes, una mirada desde los relatos de vida
Authors: Chen Mok Susan 
Published: June 2018

El objetivo de este trabajo es recuperar los relatos de vida de los inmigrantes chinos y/o sus descendientes de la ciudad de Puntarenas del siglo XX para contribuir a la construcción del proceso de la inmigración china en Costa Rica. Este estudio analiza los relatos de vida de dieciocho inmigrantes y/o descendientes directos de estos, todos adultos mayores del siglo XX. Se utiliza la técnica de relatos de vida propuesta por Bertaux (2005). Las conclusiones muestran que la comunidad china se ha insertado en la comunidad Puntarenense de manera pacífica y amistosa, aportando sus rasgos culturales y costumbres e integrándose a la vida cotidiana de esta ciudad
Política cultural pública en México y su eficacia
Authors: Cervantes Hernández Rubén , Rico Bovio Arturo 
Published: June 2018

Este ensayo tiene como objeto problematizar los procesos de la política cultural que marcan los espacios socio-culturales-administrativos ofertados por el gobierno mexicano. Elabora una caracterización general de las dinámicas del desarrollo humano y las políticas culturales de forma transversal. Describe la relación de las políticas culturales con los tratados internacionales y muestra el contexto nacional de México. Ofrece una visión histórica general de las políticas culturales, los antecedentes de estudios del consumo cultural y el PIB cultural de México. Aborda la interconexión de la Secretaría de Cultura con otras Secretarías.Esta investigación pone las bases para identificar y evaluar el desarrollo humano y otras problemáticas de las políticas culturales en el contexto específico de México.
Procesos formativos que favorecen la construcción del conocimiento profesional del profesor en futuros docentes de Biología
Authors: Valbuena Ossa Édgar Orlay , Gutiérrez Pérez Alice Marcela , Correa Sánchez Monica Alexandra , Amórtegui Cedeño Elías Francisco 
Published: June 2018

En este documento analizamos las actividades de integración desarrolladas por futuros profesores de biología, en quinto y sexto semestre del Proyecto Curricular de Licenciatura en Biología (PCLB) de la Universidad Pedagógica Nacional (Colombia), en particular, la construcción de Conocimiento Profesional del Profesor de Biología. Dichas actividades constituyen el diseño de unidades didácticas (UD) para la enseñanza de una temática de biología y la formulación de un Anteproyecto de la Práctica Pedagógica (APP) sobre educación en biología.Para ello, el estudio se concentra en dos categorías: Conocimiento Biológico (CB) y Conocimiento Profesional del Profesor de Biología (CPPB). Asimismo, el diseño de unidades didácticas posibilitó en los futuros profesores identificar e integrar los diferentes conocimientos y saberes que requiere el docente para enseñar, así como problematizar la enseñanza a partir del Conocimiento Biológico, la Pedagogía y la Didáctica, y la Epistemología de la Biología; lo cual conduce a la estructuración de contenidos, propósitos, evaluación y actividades de enseñanza. Esta estrategia favoreció principalmente la construcción de Conocimiento Didáctico del Contenido Biológico (CDCB). Para el caso de la formulación del APP, los futuros profesores reconocieron y reflexionaron sobre el saber construido en relación con la profesión docente durante los primeros seis semestres del PCLB, en el cual se destaca la fuente académica y experiencial para la construcción del conocimiento profesional.
Bom crioulo: uma narrativa naturalista silenciada pelos cânones
Authors: Ribeiro Rondinele Aparecido 
Published: June 2018

<p><strong>Resumo: </strong>Publicado em 1895, o romance <em>Bom Crioulo</em> causou muita polêmica na sociedade por ser o primeiro romance brasileiro que empregou protagonistas personagens que vivem uma relação homossexual: o negro Amaro e o jovem Aleixo. Mesmo que se enquadre nos ideais estéticos do Realismo-Naturalismo, esse romance foi esquecido pela tradição canônica, tendo sido redescoberto apenas nos anos 1950. Dessa forma, o presente artigo tem como objetivo apontar o motivo de tal silenciamento dessa obra pelo cânone nacional.</p><p><strong> </strong></p>
Factors affecting Accumulibacter population structure in full- and laboratory-scale biological reactors with nutrients removal
Authors: Muszyński A. , Załęska-Radziwiłł M. , Doskocz N. 
Published: June 2018

Abstract
The structure of Accumulibacter lineage was examined over a three-year period in six full-scale wastewater treatment plants and compared to the population in a laboratory-scale reactor. The Accumulibacter lineage reached 69% of all bacteria in the laboratory-scale reactor and contained clades IA and IIA,C,D only. In full-scale plants, Accumulibacter constituted up to 12%, correlated with sludge loading with BOD, COD, N and P. Clade IA was more abundant after periods with low temperatures, whereas clades IIA,C,D presented opposite variations. The fraction, unrevealed by clade-specific probes, constituted 31–62% of the Accumulibacter lineage in all but one full-scale plant – the population in the plant with significant industrial contribution in the influent resembled the low diversity in the laboratory-scale reactor. Selection of specific clades in the laboratory-scale reactor was associated with its different performance, despite stable operational conditions being maintained through the study. It implies that high relative abundance of Accumulibacter in bacterial community is not enough for efficient P removal and the effectiveness may also be associated with the presence of specific clades. A considerable fraction of Accumulibacter in full-scale plants, which is not targeted by clade-specific probes, should be further investigated to better characterize clades that may affect effectiveness of phosphorus removal.