bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hot snare vs. cold snare polypectomy for endoscopic removal of 4 – 10 mm colorectal polyps during colonoscopy: a systematic review and meta-analysis of randomized controlled studies
Authors: Jegadeesan Ramprasad , Aziz Muhammad , Desai Madhav , Sundararajan Tharani , Gorrepati Venkata , Chandrasekar Viveksandeep , Jayaraj Mahendran , Singh Pratiksha , Saeed Ahmed , Rai Tarun , Choudhary Abhishek , Repici Alessandro , Hassan Cesare , Fuccio Lorenzo , Sharma Prateek 
Published: May 2019

Abstract
Introduction In recent years, cold snare polypectomy (CSP) has increasingly been used over hot snare polypectomy (HSP) for the removal of colorectal polyps (4 – 10 mm in size). However, the optimal technique (CSP vs. HSP), in terms of complete polyp resection and complications, is uncertain. Our aim was to compare incomplete resection rate (IRR) of polyps and complications using CSP vs. HSP.
Methods Randomized controlled studies (RCTs) comparing CSP and HSP for removal of 4 – 10 mm colorectal polyps were considered. Studies were included in the analysis if they obtained biopsy specimens from the resection margin to confirm the absence of residual tissue and reported complications. IRR and complication rate were the outcome measures. Pooled rates were reported as Odds Ratios (OR) or risk difference with 95 % Confidence Interval (CI).
Results In total, three RCTs were included in the final analysis. A total of 1051 patients with 1485 polyps were randomized to either HSP group (n = 741 polyps) or CSP group (n = 744 polyps). The overall IRR did not differ between the two groups (HSP vs. CSP: 2.4 % vs. 4.7 %; OR 0.51, 95 %CI 0.13 – 1.99, P = 0.33, I
2 = 73 %). The HSP group had a lower rate of overall complications compared to the CSP group (3.7 % vs. 6.6 %; OR 0.53, 95 % CI 0.3 – 0.94, P = 0.03, I
2 = 0 %). Polyp retrieval rates were not different between the two groups (99 % vs. 98.1 %).
Conclusion Our results suggest that HSP and CSP techniques can be effectively used for the complete removal of 4 – 10 mm colorectal polyps; however, HSP has a lower incidence of overall complications.
Extensor pollicis longus tendon rupture caused by a
displaced dorsal “beak” fragment of Lister’s tubercle in distal radius
fractures
Authors: Lee Jun-Ku , Bang Jin-Young , Choi Yun Seong , Kim Tae-Ho , Yu Woo-Jin , Han Soo-Hong 
Published: May 2019

Abstract
Introduction Ruptures of the extensor pollicis longus (EPL) tendon are a
well-known complication of distal radius fractures (DRF). There are a lot of
suspected mechanisms, including mechanical friction, vascular impairment, injury
associated with reduction, and local adhesion. However, there have been limited
reports about a closed rupture of the EPL tendon associated with a relatively
large, displaced dorsal “beak” fracture fragment. We report about the management
outcomes and clinical significance of closed ruptures of the EPL tendon caused
by a displaced dorsal fracture fragment of beak-like appearance in DRF.
Patients/Material and Methods Our study included 7 cases of a complete
closed rupture of the EPL tendon after open reduction internal fixation. All
cases showed a similar pattern involving a relatively large dorsal beak fragment
originating from Lister’s tubercle, and we treated them with a palmar locking
plate within 7 days from the initial fracture without separate dorsal fragment
management. All patients were diagnosed with a delayed EPL tendon rupture.
Results The study included 5 female and 2 male patients. Mean patient age
was 59 years. In all cases we explored the extensor compartment III to verify
the exact cause of the EPL rupture. Six patients underwent an extensor indicis
transfer and one patient underwent tendon grafting.Mean fragment width and length were 7.0 mm and 13.3 mm, respectively. The
fragments were dorsally elevated (mean, 2.4 mm) and distally displaced (mean,
3.5 mm). At the last follow-up, the mean DASH score was 4.4. Mean thumb MP joint
flexion and extension were 4 degrees and 62 degrees, respectively.
Conclusion We support the possibility of EPL tendon rupture caused by
displaced sharp Lister’s tubercle fracture fragments.
Endovenöse Laserablation bei Stammvarikosis der Vena
saphena magna (VSM) und Vena saphena parva (VSP) sowie bei VSM-Krossenrezidiven
(KR) mit neuer radiär abstrahlender Laserfaser – 3 Monatsergebnisse einer
prospektiven single-centre-Studie
Authors: Kiderlen Martin , Schäffer Nina , Schuler Lisa , Theodoridis Athanasios , Weingard Iris , Kriechenbauer Nicola , Hartmann Karsten 
Published: May 2019

Zusammenfassung
Einleitung Die thermische Venenablation varikös veränderter Stammvenen der
unteren Extremität ist in Deutschland aufgrund der guten Wirksamkeit,
Anwendungssicherheit und hoher Patientenzufriedenheit eine anerkannte und häufig
durchgeführte Behandlungsmöglichkeit. Zielsetzung der prospektiven
Anwendungsbeobachtung (AWB) war die Untersuchung des Operationserfolges, der
Patientenzufriedenheit und des Auftretens von Nebenwirkungen bei endovenöser
Behandlung der varikös veränderten Vena saphena magna (VSM), Vena saphena parva
(VSP) sowie bei Krossenrezidiven (KR) unter Verwendung der ETQ 360° FUSED
Fiber™.
Material und Methoden Insgesamt wurden 162 varikös veränderte Venen (VSM n
= 76, VSP n = 65, KR n = 25) bei 144 Patienten behandelt und in die AWB
eingeschlossen. Ein duplexsonographisches Follow-up erfolgte nach 10–14 Tagen
sowie 3 Monaten. Die ETQ 360° FUSED Fiber™ hat eine Wellenlänge von 1470 nm bei
einem beam angle von 60°. Für die endovenöse Therapie der VSM und von KR wurde
eine Faser mit einem Faserkerndurchmesser von 600 µm bei einem
Spitzendurchmesser von 1,8 mm und 8 Watt Behandlungsenergie eingesetzt. Zur
Behandlung der VSP wurde ein Faserkerndurchmesser von 400 µm bei einem
Spitzendurchmesser von 1,3 mm und 6 Watt Behandlungsenergie gewählt.
Ergebnisse Alle thermisch behandelten VSM (n = 6) und VSP (n = 65) waren
bei Visite 2 und Visite 3 vollständig verschlossen. In der KR Gruppe (n = 25)
zeigten sich bei Visite 2 Verschlussraten von 96 % und Teilverschlussraten von 4
%. Bei Visite 3 konnten noch Verschlussraten von 80 % und Teilverschlussraten
von 16 % nachgewiesen werden. In 4 % der Fälle kam es zu einer vollständigen
Rekanalisierung. Tiefe Beinvenenthrombosen (TVT) oder Lungenembolien (LE) wurde
in keiner der Kohorten diagnostiziert. 1,4 % der an der VSM behandelten
Patienten gaben bei Visite 3 Sensibilitätsstörungen im Behandlungsareal an, in
der VSP Gruppe waren es 6,15 %. Patienten der KR Kohorte gaben keinerlei
Einschränkungen bezüglich der Sensibilität an. Die Patientenzufriedenheit war in
allen Gruppen sehr hoch, in allen 3 Gruppen verbesserte sich der Venous Clinical
Severity Score (VSCC) signifikant.
Zusammenfassung Die Behandlung der VSM, VSP und von KR mit der ETQ 360°
FUSED Fiber™ ist effizient, komplikationsarm und mit einer hohen
Patientenzufriedenheit assoziiert.
Einfluss des Diabetes mellitus Typ II auf Inzidenz, Mikrobiologie, Verlauf und Prognose des Erysipels
Authors: Eickenscheidt L. , Pönnighaus J.-M. , Kowalzick L. 
Published: May 2019

Zusammenfassung
Hintergrund und Fragestellung Die Behandlung des Erysipels, einer klassischen Infektionskrankheit in der Dermatologie, wird durch die Auswirkungen des demografischen Wandels und multimorbidere Patienten zunehmend kompliziert. Es gibt kaum miteinander vergleichbare Daten zu Zusammenhängen zwischen Diabetes mellitus und Erysipelen. Anhand der Patienten des Helios Vogtland-Klinikums Plauen wird die Rolle des Diabetes mellitus als Risikofaktor für die Inzidenz und den Verlauf von Erysipelen untersucht.
Patienten/Methodik In einer retrospektiven Untersuchung wurden 592 Patienten, die in den Jahren 2007 – 2017 stationär behandelt wurden, ausgewertet. Die Einschlusskriterien waren: Alter über 18 Jahre, Antibiose > 5 Tage und Plausibilität der Befunde bei stationärer Aufnahme sowie eine vorliegende Diabetes-Diagnostik bzw. -Behandlung. Mikrobiologische Befunde waren kein Kriterium.
Ergebnisse Durchschnittlich 42 % der stationär behandelten Patienten mit Erysipel waren auch an einem Diabetes mellitus Typ II erkrankt oder hatten einen okkulten Diabetes, während der Anteil von Diabetes-Patienten im Krankenhaus insgesamt nur konstant ca. 20 % betrug (p < 0,001). Ein Wechsel des primär eingesetzten i. v. -Antbiotikums war bei Erysipel-Patienten mit einem Diabetes mellitus Typ II oder einem okkulten Diabetes aufgrund eines Therapieversagens in 46 % der Fälle erforderlich, bei Patienten ohne Diabetes mellitus in 33 % (OR: 1,7, p = 0,005). Eine Sepsis entwickelten 11 % bzw. 4 % (OR: 2,8, p = 0,002) und stationär behandelte Rezidive 19 % bzw. 10 % (OR: 2,0, p = 0,007) der jeweiligen Kollektive mit und ohne gleichzeitigem Diabetes. Bei Patienten mit Diabetes mellitus Typ II zeigte sich ein signifikant besseres Ansprechen auf die Kombination Ceftriaxon/Ciprofloxacin als auf die Monotherapie mit Penicillin G (OR 4,1 [95 % CI 2,1 – 7,6]; p < 0,005).
Schlussfolgerungen Der Diabetes mellitus Typ II stellt bei stationär behandelten Patienten einen Risikofaktor für Inzidenz, Verlauf und Prognose der Erysipel-Erkrankung dar. Stationär behandelte Patienten mit Erysipel sollten ein Diabetes-Screening erhalten. Patienten mit klinischem Erysipel und Diabetes mellitus Typ II profitieren von der leitlinienempfohlenen Standard-Antibiose möglicherweise weitaus weniger als bisher angenommen.
Sarcoma of the Lower Limb: Reconstructive Surgeon's Perspective
Authors: Lim Zhixue , Strike Sophia A. , Puhaindran Mark E. 
Published: May 2019

AbstractManagement of sarcomas in the lower extremities have evolved from amputations to limb-preserving surgeries with evidence to support that they have equal overall survival, albeit with better functional outcome. The challenge of reconstruction lies in providing a durable, functional, and aesthetically pleasing limb. However, limb-preserving intention should not delay interventions that provide a survival benefit such as chemotherapy and radiotherapy. The advent of radiotherapy and chemotherapy also has implications on wound healing and should be considered during the reconstructive process. This article reviews the methodical approach, reconstructive strategies, and considerations for the reconstructive surgeon with respect to the lower extremity after sarcoma excision.
Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects
Authors: De Cristofaro Raimondo , Sacco Monica , Lancellotti Stefano , Berruti Federico , Garagiola Isabella , Valsecchi Carla , Basso Maria , Di Stasio Enrico , Peyvandi Flora 
Published: May 2019

Background Recombinant (rec-) coagulation factor VIII concentrates available for hemophilia A (HA) treatment differ in cell line production and structure, which could affect their pharmacodynamics and immunogenicity. Clinical trials showed that previously untreated patients with severe HA present higher rates of inhibitor development if treated with rec-FVIII products and that differences do exist as to inhibitor's formation among different rec-FVIII products. This finding could arise from several causes, such as absence of von Willebrand factor, different glycosylation profiles, or processes of molecular aggregation of the recombinant FVIII molecules.
Objectives/Methods In this study, using size exclusion high-performance liquid chromatography (SE-HPLC), dynamic light scattering (DLS) spectroscopy, and functional biochemical assays, we investigated the purity grade, FX activating ability, and aggregation status of three recombinant marketed products (Advate [Baxalta], Refacto AF [Pfizer], and Kogenate [Bayer]).
Results The overall analysis of the results obtained with SE-HPLC and DLS spectroscopy showed that the three recombinant FVIII concentrates contain low but significant amounts of molecular aggregates. This phenomenon was less evident for the Advate product. Molecular aggregation negatively affects the in vitro pharmacodynamics of the concentrates with higher aggregates' content.
Conclusions This study shows that the three pharmaceutical formulations of recombinant FVIII contain variable amounts of molecular aggregates after their reconstitution at therapeutic concentrations. This phenomenon negatively affects the in vitro potency of the products with higher aggregates' content and might be invoked as a contributing cause of their increased risk to induce the formation of FVIII inhibitors.
Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records
Authors: Hornik Christoph , Atz Andrew , Bendel Catherine , Chan Francis , Downes Kevin , Grundmeier Robert , Fogel Ben , Gipson Debbie , Laughon Matthew , Miller Michael , Smith Michael , Livingston Chad , Kluchar Cindy , Heath Anne , Jarrett Chanda , McKerlie Brian , Patel Hetalkumar , Hunter Christina ,   on behalf of the Best Pharmaceuticals for Children Act–Pediatric Trials Network
Published: May 2019

Background Integration of electronic health records (EHRs) data across sites and access to that data remain limited.
Objective We developed an EHR-based pediatric inpatient repository using nine U.S. centers from the National Institute of Child Health and Human Development Pediatric Trials Network.
Methods A data model encompassing 147 mandatory and 99 optional elements was developed to provide an EHR data extract of all inpatient encounters from patients <17 years of age discharged between January 6, 2013 and June 30, 2017. Sites received instructions on extractions, transformation, testing, and transmission to the coordinating center.
Results We generated 177 staging reports to process all nine sites' 147 mandatory and 99 optional data elements to the repository. Based on 520 prespecified criteria, all sites achieved 0% errors and <2% warnings. The repository includes 386,159 inpatient encounters from 264,709 children to support study design and conduct of future trials in children.
Conclusion Our EHR-based data repository of pediatric inpatient encounters utilized a customized data model heavily influenced by the PCORnet format, site-based data mapping, a comprehensive set of data testing rules, and an iterative process of data submission. The common data model, site-based extraction, and technical expertise were key to our success. Data from this repository will be used in support of Pediatric Trials Network studies and the labeling of drugs and devices for children.
Different Strategies in Making Transseptal Portal for the Different Purposes
Authors: Lee Yong Seuk , Kim Tae Woo , Lee Eui Soo , Lee Kyoung Hwan , Lee Seung Hoon 
Published: May 2019

AbstractThe purpose of this study was to find the most suitable and safe position of the transseptal portal in anatomic anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstructions. The hypothesis of this study was that area and position of the transseptal portal are different between ACL and PCL reconstructions for the observation of native footprint. A matched-pair comparison study was conducted on the arthroscopic images of 100 consecutive patients who underwent ACL reconstruction and 50 consecutive patients who underwent PCL reconstruction. The transseptum was divided into six compartments. The opened compartments for each surgery were then evaluated to find which anatomical structures are well seen. The anterior middle and upper parts were necessary for the ACL reconstruction, whereas middle and lower portions of the anterior and posterior compartments were necessary for the PCL reconstruction. A larger opening was necessary for PCL reconstruction than that for ACL reconstruction. The ACL posterior one-third, ACL femoral attachment, and apex of the deep cartilage margin (DCM) were viewed in 100% of the patients during ACL reconstruction. The PCL posterior one-third, PCL tibial attachment, PCL fovea margin, and medial meniscus around posterior margin were always viewed during PCL reconstruction. The anterior part of the septum, from the middle to the upper portions of the transseptum, was necessary to be opened for visualization of the femoral footprint and DCM of the lateral femoral condyle during ACL reconstruction. The anterior and posterior parts of the septum, from the middle to the lower portions of the transseptum, were necessary for excellent visualization of the PCL tibial footprint during PCL reconstruction. These paths of the transseptal portal for each surgery will help surgeons obtain both anatomic footprint restoration and maximal remnant preservation through the most suitable and safe means. This is a case–control study; level of evidence is 3.
Do Individual Differences in Physical Therapists' Skills Affect Postoperative Results of Total Knee Arthroplasty?
Authors: Fujii Tadashi , Nishio Naoyuki , Bandou Minenari , Kitano Shuji , Noboru Marehoshi , Seko Munehito , Inagaki Yusuke , Tanaka Yasuhito 
Published: May 2019

AbstractWe investigated variations in postoperative outcomes of total knee arthroplasty which were dependent on the physical therapist (PT) who performed rehabilitation while keeping other parameters as uniform as possible. Seventy-nine among 690 knees were selected based on strict inclusion and exclusion criteria. Patients were randomly assigned to five PTs, who had from 2 to 21 years of experience. Range of motion (ROM) on postoperative days (PODs) 1, 3, 7, and 14 and at postoperative months 3, 6, and 12, results of timed up and go (TUG) test on POD 14, time to walking with a single cane, and time to climbing stairs, were evaluated. There were significant differences until POD 3, and no significant differences afterward in flexion. There was a significant difference on POD 1 only in extension. The TUG test showed no significant difference, but there were significant differences at the time of walking with a single cane and climbing stairs. The time taken to achieve rehabilitation, which was determined subjectively by each PT, differed among therapists, but differences in ROM were present in early period. Therefore, ROM after surgery is not affected by differences between PTs.
Evaluation of the PROMIS Physical Function Computer Adaptive Test in Patients Undergoing Knee Surgery
Authors: Miles Megan , Nadarajah Vidushan , Jauregui Julio J. , Dubina Andrew G. , Smuda Michael P. , Bennett Craig H. , Packer Jonathan D. , Henn R. Frank 
Published: May 2019

AbstractA cross-sectional analysis of data derived from patients undergoing knee surgery at a single institution was conducted. The objectives of the study were to (1) compare how the Patient-Reported Outcomes Measurement Information System physical function (PROMIS PF) computer adaptive test performs against the International Knee Documentation Committee (IKDC) Subjective Knee Form in evaluating functional status, and (2) to determine demographic, clinical, and psychosocial correlates of each outcome measure in an urban population undergoing a variety of knee surgeries. We hypothesized that there would be a strong correlation between PROMIS PF and IKDC, with minimal floor and ceiling effects, and similar clinical correlates. The sample consisted of 412 patients undergoing knee surgery. Bivariate and multivariable statistical analyses were performed to identify significant independent predictors. The PROMIS PF and IKDC scores were strongly correlated (r
s = 0.71, p < 0.001), and neither exhibited floor nor ceiling effects. Lower body mass index, no preoperative opioid use, lower Charlson comorbidity index score, employment, and lower income were found to be significant independent predictors for better scores on both PROMIS PF and IKDC. Patients undergoing total knee arthroplasty had significantly lower PROMIS PF and IKDC scores (p < 0.05). Potential explanations for these findings are presented, and clinical implications are discussed.
Vein Size Mismatch Increases Flap Failure in Lower Extremity Trauma Free Flap Reconstruction
Authors: Lee Z-Hye , Alfonso Allyson R. , Stranix John T. , Anzai Lavinia , Daar David A. , Ceradini Daniel J. , Levine Jamie P. , Saadeh Pierre B. , Thanik Vishal 
Published: May 2019

Abstract
Background Venous outflow problems are the most common reasons for perioperative flap complications. Size mismatch in venous anastomoses poses a theoretical problem by promoting turbulent flow and subsequent thrombus formation. The purpose of this study was to determine if increased vein size mismatch is predictive of flap failure.
Methods Retrospective review of our institutional flap registry from 1979 to 2016 identified 410 free flaps performed for reconstruction of lower extremity trauma. Patient demographics, flap characteristics, and flap outcomes were examined. Venous size mismatch was defined as a difference in size ≥ 1 mm between the recipient vein and flap vein.
Results Vein size mismatch ≥ 1mm was present in 17.1% (n = 70) of patients. The majority of anastomoses were end-to-end (n = 379, 92.4%), and end-to-side anastomoses were preferentially used in the presence of vein size mismatch (p < 0.001). Major complications occurred in 119 (29%) flaps, with 35 (8.5%) partial flap losses and 34 (8.3%) total flap losses. Looking specifically at flaps with end-to-end venous anastomoses, venous size mismatch was associated with increased total flap failure (p = 0.031) and takeback for vascular compromise (p = 0.030). Recipient vein size relative to flap vein size (larger or smaller) had no effect on flap outcomes. Multivariable regression analysis controlling for age, sex, flap type, number of veins, recipient vein size, flap vein size, venous coupler use, and vein size mismatch demonstrated that flaps with ≥ 1 mm vein mismatch were predictive of total flap failure (p = 0.045; odds ratio: 2.58).
Conclusion Flaps with vein size mismatch ≥ 1 mm demonstrated increased flap complication rates in the setting of end-to-end venous anastomoses. End-to-side anastomosis was preferentially used in vein size mismatch and carried a higher risk of flap failure. Our results support using veins of similar size for anastomosis whenever feasible to protect against flap complications.
System of ideal quantum dots with Coulomb interaction
Authors: Mandel A.M. , Oshurko V.B. , Pershin S.M. 
Published: May 2019

Abstract
The wave functions of single-electron states localised on a system of single-level ideal quantum dots in a semiconductor matrix are constructed. The standard Kane theory, which describes the renormalisation of the effective mass of electrons in bulk III − V semiconductors, is transformed, for the first time as far as we know, for small-size quantum dots. The renormalised electron mass in a quantum dot depends on its ground state energy, which, in turn, depends on this mass. Thus, a self-consistent problem is obtained for calculating the electron binding energy. The radius of the Debye screening of the Coulomb interaction in a system of quantum dots is calculated at room temperature. The Coulomb repulsion of electrons localised on dots limits from above the possible number of filled dots. The condition is formulated for the optimal concentration of quantum dots. A classical distribution function for the probability of quantum dot filling is constructed. It is found the state, where electrons fill exactly half the maximum possible number of filled dots, exhibits the minimal energy (and therefore the most stable), the condition being fairly universal. In particular, it can be used to estimate the limiting efficiency of quantum-dot diode lasers.
Modelling of polarised optical frequency domain reflectometry of axially twisted anisotropic optical fibres
Authors: Barkov F.L. , Konstantinov Yu.A. , Bochkova S. D. , Smirnov A.S. , Burdin V.V. , Krivosheev A.I. , Nosova E.A. , Smetannikov O.Yu. 
Published: May 2019

Abstract
This paper presents a mathematical model that describes the influence of defects in an anisotropic optical fibre on its polarised frequency domain reflectograms. The model relies on the Jones matrix formalism. Calculated reflectograms are presented for a uniform axial twist of an optical fibre. As input data for simulation, we use real distributed optical parameters of the fibre determined by polarised light Brillouin reflectometry.