bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Positive Pressure Treatment of the Airway on Health-Related Quality of Life in Elderly Patients With Obstructive Sleep Apnea
Authors: Serrano Merino Jesús , Pérula de Torres Luis Ángel , Bardwell Wayne A. , Muñoz Gómez Rafaela , Roldán Villalobos Ana , Feu Collado Nuria , Ruiz-Moral Roger , Jurado-Gámez Bernabé 
Published: May 2018

Background: Obstructive sleep apnea (OSA) is a chronic illness that increases in prevalence with age. Treatment includes continuous positive airway pressure (CPAP) devices. Studies about the use of CPAP in the elderly are scarce. The main objective of this study is to determine whether CPAP contributes to improvement in health-related quality of life (HRQL) in elderly patients with OSA. Method: This was a prospective, pre-/postintervention assessment of a cohort of patients ≥65 years of age with OSA diagnosis by polysomnography who were being treated with CPAP and were physically independent and had good cognitive status. We determined HRQL before and after 3 months of CPAP treatment using the Short Form-36 Health Survey (SF-36, a 36-item, patient-reported survey) and Sleep Apnea Quality of Life Index (SAQLI). The effect of CPAP on daytime sleepiness was assessed with the Epworth Sleepiness Scale (ESS). Results: Of the 103 participants with a mean age of 71.5 ± 4.19 years, 66% were male. After 3 months of therapy, the mean CPAP usage was 6.3 ± 1.41 hr/day. The effectiveness of CPAP in controlling the OSA was demonstrated (mean difference pre- and posttherapy: 34.30 ± 18.52 events/hr, p < .001). Postintervention, the categories of the SF-36 improved meaningfully ( p < .001). Moreover, all categories of SAQLI improved ( p < .001) with the exception of “symptoms” ( p = .073). ESS scores also improved significantly (difference = 5.2 ± 4.47, p < .001) postintervention. Conclusion: Therapy with CPAP in elderly patients with OSA helps improve their HRQL and reduces daytime sleepiness.
Patient reported adverse events among epileptic patients taking antiepileptic drugs
Authors: Ayalew Mohammed Biset , Muche Esileman Abdela 
Published: May 2018

Objective: The aim of this study was to assess patient reported adverse events and associated factors among epileptic patients taking antiepileptic drugs on follow-up at University of Gondar Referral Hospital. Methods: Cross-sectional study was done on 354 adult epileptic patients. Patients who were on antiepileptic drugs for epilepsy treatment for less than a year, those who were below 18 years old, patients with incomplete information on the chart and those who were involuntary or uncooperative were excluded from the study. Data were entered in to SPSS version 20.0 for analysis. Bivariate and multivariate binary logistic regression analysis was done to see factors associated with antiepileptic drugs adverse effect. Level of statistical significance was declared at p ≤ 0.05. Result: Generalized tonic clonic seizure was the most common (86.2%) type of epilepsy. A total of 79 adverse events were reported. The most frequently encountered adverse events were fatigue (5.08%), gastrointestinal disturbance (4.24%) and sedation/depression (4.24%). Adverse drug effect of antiepileptic drugs was significantly associated with illiterate educational status, increased number of antiepileptic drugs, no seizure during last follow-up and last year, and 1–5 seizures for the last year. Conclusion: About one-sixth of epileptic patients reported adverse drug effects. Adverse drug effects were more commonly seen in patients with low educational status, increased number of antiepileptic drugs, absence of seizure during last follow-up and last year, and 1–5 seizures for the last year. So clinicians should give emphasis for patients with these characteristics to counsel on how to minimize or prevent adverse drug events from antiepileptic drugs or giving reassurance about it if it is minor.
B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation
Authors: Miggelbrink Alexandra M. , Logan Brent R. , Buckley Rebecca H. , Parrott Roberta E. , Dvorak Christopher C. , Kapoor Neena , Abdel-Azim Hisham , Prockop Susan E. , Shyr David , Decaluwe Hélène , Hanson Imelda C. , Gillio Alfred , Dávila Saldaña Blachy J. , Eibel Hermann , Hopkins Gregory , Walter Jolan E. , Whangbo Jennifer S. , Kohn Donald B. , Puck Jennifer M. , Cowan Morton J. , Griffith Linda M. , Haddad Elie , O’Reilly Richard J. , Notarangelo Luigi D. , Pai Sung-Yun 
Published: May 2018

Key Points
IL2RG/JAK3-deficient B cells remain intrinsically defective posttransplant despite follicular helper T-cell reconstitution. In vitro response of B cells to IL-21 is a potential biomarker for humoral immunity in patients with IL2RG/JAK3 SCID after transplantation.
Immune regulatory cell infusion for graft-versus-host disease prevention and therapy
Authors: Blazar Bruce R. , MacDonald Kelli P. A. , Hill Geoffrey R. 
Published: May 2018

AbstractCurrent approaches to prevent and treat graft-versus-host disease (GVHD) after stem cell transplantation rely principally on pharmacological immune suppression. Such approaches are limited by drug toxicity, nonspecific immune suppression, and a requirement for long-term therapy. Our increased understanding of the regulatory cells and molecular pathways involved in limiting pathogenic immune responses opens the opportunity for the use of these cell subsets to prevent and/or GVHD. The theoretical advantages of this approach is permanency of effect, potential for facilitating tissue repair, and induction of tolerance that obviates a need for ongoing drug therapy. To date, a number of potential cell subsets have been identified, including FoxP3+ regulatory T (Treg) and FoxP3negIL-10+ (FoxP3-negative) regulatory T (Tr1), natural killer (NK) and natural killer T (NKT) cells, innate lymphoid cells, and various myeloid suppressor populations of hematopoietic (eg, myeloid derived suppressor cells) and stromal origin (eg, mesenchymal stem cells). Despite initial technical challenges relating to large-scale selection and expansion, these regulatory lineages are now undergoing early phase clinical testing. To date, Treg therapies have shown promising results in preventing clinical GVHD when infused early after transplant. Results from ongoing studies over the next 5 years will delineate the most appropriate cell lineage, source (donor, host, third party), timing, and potential exogenous cytokine support needed to achieve the goal of clinical transplant tolerance.
Narrative medicine educational project to improve the care of patients with chronic obstructive pulmonary disease
Authors: Cappuccio Antonietta , Sanduzzi Zamparelli Alessandro , Verga Massimo , Nardini Stefano , Policreti Alessandro , Porpiglia Pasquale Alberto , Napolitano Silvia , Marini Maria Giulia 
Published: May 2018

Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of pulmonary function. Often patients do not adhere to inhaled therapies and this leads clinicians to switch treatments in order to improve control of the symptoms. Narrative medicine is a useful approach that helps healthcare professionals to think over the doctor–patient relationship and how patients live with their disease. The aim of this training project was to teach pulmonologists the basics of narrative medicine: to carefully listen to patients and to practice reflective writing in their relationship with them.Training on narrative medicine and parallel charts was provided through a webinar and a weekly newsletter.Across 362 narratives, written by 74 Italian pulmonologists, 92% of patients had activity limitations at their first visit. The main factor influencing the effectiveness and adherence to therapy was a positive doctor–patient relationship; indeed, if such relationship is difficult, only 21% of patients are able to resume all their activities.After learning the narrative approach, clinicians became aware of the need to spend more time listening to patients, to reflect through writing and to understand more deeply the motivations that lead people towards adherence to new therapies.
Somatic mutation landscape of a meningioma and its pulmonary metastasis
Authors: Du Yaran , Lu Ting , Huang Song , Ren Fangfang , Cui Gang , Chen Jian 
Published: May 2018

AbstractBackgroundExtracranial metastasis (ENM) of meningiomas is extremely rare, and typically occurs several years after a primary tumor is diagnosed. However, the genetic changes underlying ENM events have not yet been investigated.Case presentationA 58‐year‐old male patient was sent to the emergency room of our hospital because of a sudden fall. Magnetic resonance imaging detected a mass at the right frontal sagittal sinus. He underwent tumor resection and recovered well, but post‐operative computed tomography revealed three lumps on the right side of his chest. Thoracic surgery was performed to remove two of the lumps. Pathological findings revealed that the brain and lung tumors were grade I meningiomas. The patient received no additional radiation or chemotherapy post‐surgery, and there was no sign of tumor recurrence in the brain or progression of the remaining lump in the chest 1 year after surgery. We performed whole exome sequencing of the patient's blood, primary brain tumor, and lung metastatic tumor tissues to identify somatic genetic alterations that had occurred during ENM. This revealed that a frameshift deletion of the neurofibromin 2 gene likely drove formation of the meningioma. Surprisingly, we found that the brain tumor was relatively homogeneous and contained only one dominant clone; both the pulmonary metastasis and the original brain tumor were derived from the same clone, and no obvious additional driver mutations were detected in the metastatic tumor.ConclusionAlthough ENM of meningiomas is very rare, brain tumor cells appear to be more adaptable to tissue microenvironments outside of the central nervous system than was commonly thought.
Open Source Software and Firm Productivity
Authors: Nagle Frank 
Published: May 2018

As open source software (OSS) is increasingly used as a key input by firms, understanding its impact on productivity becomes critical. This study measures the firm-level productivity impact of nonpecuniary (free) OSS and finds a positive and significant value-added return for firms that have an ecosystem of complementary capabilities. There is no such impact for firms without this ecosystem of complements. Dynamic panel analysis, instrumental variables, and a variety of robustness checks are used to address measurement error concerns and to add support for a more causal interpretation of the results. For firms with an ecosystem of complements, a 1% increase in the use of nonpecuniary OSS leads to an increase in value-added productivity of between 0.002% and 0.008%. This effect is smaller for larger firms, and the results indicate that prior research underestimates the amount of IT firms use.The online appendix is available at https://doi.org/10.1287/mnsc.2017.2977 .This paper was accepted by Chris Forman, information systems.
Retail Clusters in Developing Economies
Authors: Zhao Xuying , Lim Arthur , Guo Hong , Ding Chao , Song Jing-Sheng 
Published: May 2018

We develop a game-theoretic model to explore why retail clusters are so popular in developing economies and when governments should facilitate the formation of retail clusters to improve social welfare. First, we find two determinants of retailer clusters: the valuation-cost ratio (consumers’ maximum valuation over retailers’ production cost) and retailer density (the number of retailers over unit transportation cost). The valuation-cost ratio and retailer density indicate retailers’ profit potential and competition intensity, respectively. Second, the equilibrium cluster size increases in the valuation-cost ratio. This finding explains the phenomenon that clusters are usually larger in developing economies (where numerous retailers sell unrecognized brands with low profit potential) than in developed economies. Third, when the retailer density of a product market exceeds a certain threshold, the market coverages of clusters overlap with each other (i.e., the overlapping case). Furthermore, when compared with the nonoverlapping case, the equilibrium cluster size in the overlapping case is larger for low-profit-potential products but smaller for high-profit-potential products. Together, valuation-cost ratio and retailer density define four types of clusters: overlapping massive clusters, nonoverlapping large clusters, nonoverlapping small clusters, and overlapping mini-clusters. Finally, the socially optimal cluster size is larger than the equilibrium cluster size, and the gap between these two cluster sizes decreases in the valuation-cost ratio.The online appendix is available at https://doi.org/10.1287/msom.2017.0663 .This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Value Chain Innovations in Developing Economies.
Tablets of Stone or DNA? TV series bibles
Authors: Macdonald Ian W. 
Published: May 2018

Abstract
The term ‘bible’ is applied loosely to a document setting out the essential elements of a screen narrative, usually a TV series but also a film (especially if it is complex or part of a franchise) or digital medium. Advice from published manuals, and information from professional writers suggest its use, form, purpose and meaning is both vaguely applied and little understood. Investigation of around 40 such bibles, plus another 90 historic sales documents, mostly from the United Kingdom, suggests a series bible can be defined as: A document (or documents) which propose(s) a screen idea, in ways which identify it as a unique story-world or narrative context sufficient to host new stories yet to be written. The term bible covers at least six different types of document: (A) a writer’s framework; (B) a sales document; (C) a re-definition of the elements after purchase; (D) a development tool; (E) a ‘codification’ or archive of story ‘case-law’; and (F) a sales document for the finished screen-text. The elements included vary in each, but the core items are usually concept, place, character and storyline examples. A bible may not actually be a document; it can for example be a wall-chart during development stages (D), or even a human expert in the series’ story history (E) – a ‘walking bible’. The question of how we are to view it, whether as a statement of the DNA (or essence) of a narrative yet to be produced, or as Tablets of Stone whose information is regarded as sacred, depends on how the bible is being used at the time, i.e. whether the Screen Idea Work Group is looking forward to a new series, or backward to ensure new ideas fit the understood template.
Screenwriting, adaptation and reincarnation: Ruth Prawer Jhabvala’s self-adapted screenplays
Authors: Fryer Laura 
Published: May 2018

Abstract
Referring to the self-adapted screenplays of Ruth Prawer Jhabvala, this article argues for a conceptualization of adaptation as a collaborative continuum. To do this I develop Kamilla Elliott’s ‘Incarnational Concept’ of adaptation and propose a reincarnational concept. Jhabvala adapted her novels The Householder ([1960] 2004) and Heat and Dust (1975) to screenplays as well as Three Continents (1987) and the short story ‘How I Became a Holy Mother’ (1976), although the latter two were unmade. Jhabvala’s self-adapted screenplays attempt to retain control of certain aspects of adaptation; however, her predominant approach is to encourage collaborative input from filmmakers and the rewriting of her stories. Therefore, these insights into Jhabvala’s open approach to self-adapting demonstrate screenwriting and adaptation as collaborative, continual processes befitting a model of reincarnation.
Virtual sidekick: Second-person POV in narrative VR
Authors: Larsen Mads 
Published: May 2018

Abstract
Today’s virtual reality (VR) restricts the screenwriter with its technological shortcomings, and there is little agreement on how stories should be told in the new format. While its immersivity heightens the audience’s sense of presence, and perhaps accentuates empathy, it draws attention away from plot and information, favouring mood and emotion. While the narrative VR of the mid-2010s favoured first-person point-of-view (POV) protagonists, what we must consider is how, as technological advances grant audiences ever-greater agency, traditional storytelling collapses when said audiences can take autonomous action and affect the plot. A disembodied third-person POV, as in regular cinema, is also unlikely to satisfy audiences. This paper argues that second-person POV, where the viewer is the protagonist’s sidekick, is the device that will allow future VR audiences to fully immerse and interact without giving up our perennial pleasures of plot, character arc and leaning back while others do the work. In the 2020s, narrative VR’s economies of production are also likely, through an uberization of filmmaking, to dramatically change the industry and the role of the screenwriter.
Distal Left Main Coronary Artery Aneurysm Resection during 5-Vessel Coronary Artery Bypass Grafting
Authors: Villano Nicholas P. , Kwon Murray , Ardehali Reza 
Published: May 2018

Coronary artery aneurysms are abnormal dilations of arterial segments, in some cases associated with underlying atherosclerosis. Although affected patients can be asymptomatic, some are at risk of plaque rupture, dissection, and other complications. Investigations into the optimal management of these vascular malformations are ongoing, because no consensus exists regarding when and how best to intervene.
We present the case of a 58-year-old man whose large left main coronary artery aneurysm we ligated and removed during 5-vessel coronary artery bypass grafting. This distal aneurysm was at the trifurcation level of the patient's left anterior descending and left circumflex coronary arteries. In addition, we discuss considerations about left main coronary artery aneurysms and their treatment.
Singularly Perturbed Fractional Schrödinger Equation Involving a General Critical Nonlinearity
Authors: Jin Hua , Liu Wenbin , Zhang Jianjun 
Published: May 2018

Abstract
In this paper, we are concerned with the existence and concentration phenomena of solutions for the following singularly perturbed fractional Schrödinger problem:

ε

2
⁢
s

⁢

(

-
Δ

)

s

⁢
u

+

V
⁢

(
x
)

⁢
u

=

f
⁢

(
u
)

in
⁢

ℝ
N

,

\varepsilon^{2s}(-\Delta)^{s}u+V(x)u=f(u)\quad\text{in }\mathbb{R}^{N},

where

N
>

2
⁢
s

{N>2s}

and the nonlinearity f has critical growth. By using the variational approach, we construct a localized bound-state solution concentrating around an isolated component of the positive minimum point of V as

ε
→
0

{\varepsilon\rightarrow 0}

. Our result improves the study made in [X. He and W. Zou, Existence and concentration result for the fractional Schrödinger equations with critical nonlinearities, Calc. Var. Partial Differential Equations 55 2016, 4, Article ID 91], in the sense that, in the present paper, the Ambrosetti–Rabinowitz condition and the monotonicity condition on

f
⁢

(
t
)

/
t

{f(t)/t}

are not required.
Entwurf, Modellierung und Verifikation von Serviceabhängigkeiten in Prozessmodulen
Authors: Ladiges Jan , Köcher Aljosha , Clement Peer , Bloch Henry , Holm Thomas , Altmann Paul , Fay Alexander , Urbas Leon 
Published: May 2018

Zusammenfassung
Dieser Beitrag beschreibt eine Methode für das Engineering von Abhängigkeiten zwischen Services, die ein Modul einer Produktionsanlage in der Prozessindustrie anbietet. Hierzu wird eine Serviceabhängigkeitsmatrix eingeführt, die beim Engineering eines Moduls genutzt werden kann, um die Abhängigkeiten zwischen Services festzulegen. Die Services werden jeweils als Petri-Netz beschrieben und durch die Abhängigkeiten in eine zusammenhängende Petri-Netz-Struktur überführt. Zur effizienten Darstellung der Services und ihrer Abhängigkeiten wird, basierend auf dem PNML-Kernmodell, ein neuer Petri-Netz-Typ eingeführt, die ServiceNets. Eine formale Analyse dieser Petri-Netze erlaubt die Verifikation u. a. hinsichtlich erreichbarer Zustände und Deadlock-Freiheit.
Semantische Ermittlung kinematischer Fähigkeiten aus Anlagenplanungsdaten
Authors: Glawe Matthias , Hildebrandt Constantin , Peschke Jörn , Fay Alexander 
Published: May 2018

Zusammenfassung
Zur klaren, möglichst automatisierbaren Beantwortung der Frage, ob ein Fertigungssystem einen Produktionsauftrag realisieren kann, bedarf es einer möglichst rechnerbasiert auswertbaren Fähigkeitsbeschreibung. Für heutige Fertigungssysteme liegt eine solche Fähigkeitsbeschreibung meist nicht vor und müsste durch Auswertung vorliegender Engineering-Artefakte (z. B 3D-CAD-Modelle) von Experten manuell erstellt werden. Der vorliegende Beitrag zeigt eine Methode auf, um die Lücke zwischen vorliegenden Engineering-Artefakten und notwendigen Fähigkeitsbeschreibungen zu schließen. Dabei wird anhand der Ermittlung kinematischer Fähigkeiten aus 3D-CAD-Daten ein Ansatz zur automatischen, regelbasierten Ermittlung der Fähigkeiten aufgezeigt und die Repräsentation der ermittelten Fähigkeiten in Form einer Ontologie zur weiteren, Plattform-übergreifenden Verwendung dargestellt.
Agreeing to Disagree with Conditional Probability Systems
Authors: Tsakas Elias 
Published: May 2018

Abstract
In this note, we extend Aumann’s agreement theorem to a framework where beliefs are modelled by conditional probability systems à la Battigalli, P., and M. Siniscalchi. 1999. “Hierarchies of Conditional Beliefs and Interactive Epistemology in Dynamic Games.” Journal of Economic Theory 88: 188–230. We prove two independent generalizations of the agreement theorem, one where the agents share some common conditioning event, and one where they may not.
Using authentic spoken language across all levels of language teaching: Developing discourse and interactional competence
Authors: Tao Hongyin , Salaberry M. Rafael , Yeh Meng , Burch Alfred Rue 
Published: May 2018

AbstractThis journal issue contains a number of papers/teaching units that are dedicated to the review and analysis of some ways in which authentic language materials can be used for the teaching and learning of Mandarin Chinese from the beginning to advanced levels. We first describe the rationale for the expanded use of authentic language data in classroom instruction, and then we present four exploratory units to showcase some of the effective classroom teaching procedures that are useful to make learners aware of (and eventually use) important features of language interaction in Chinese. The units use two types of authentic materials: natural conversations and entertainment media (TV and movies). Some of the materials, due to the nature of the communicative settings associated with them, raise important theoretical questions about norms and expectations of (intercultural) communication and goals of language learning. This introduction provides a brief review of the theoretical foundations of the sample units and an overview of the units presented here.