bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study
Authors: Chen Xiaoming , Li Hong , Zhang Qian , Wang Jiye , Zhang Wenbin , Liu Jian , Li Baojuan , Xin Zhenlong , Liu Jie , Yin Hong , Chen Jingyuan , Kong Yazhuo , Luo Wenjing 
Published: June 2019

AbstractThe study of individuals at high‐altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age‐matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface‐based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract‐based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high‐altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea‐level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure.
Vessels Encapsulating Tumor Clusters (VETC) Is a Powerful Predictor of Aggressive Hepatocellular Carcinoma
Authors: Renne Salvatore Lorenzo , Woo Ha Young , Allegra Sarah , Rudini Noemi , Yano Hirohisa , Donadon Matteo , Viganò Luca , Akiba Jun , Lee Hye Sun , Rhee Hyungjin , Park Young Nyun , Roncalli Massimo , Di Tommaso Luca 
Published: June 2019

We investigated the clinical significance of a vascular growth pattern of hepatocellular carcinoma (HCC), the vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination. VETC was assessed in a large multi‐institutional cohort of 541 resected HCCs from Italy, Korea and Japan, and matched against a full spectrum of clinical and pathological variables. The VETC phenotype (defined as ≥ 55% tumor area by CD34 immunostaining) was easily reproducible and reliably detectable in whole sections and small‐sized tissues of tissue microarray. VETC HCCs represented 18.9% of the whole series, the lowest proportion occurring in the cohort with smallest tumors (8.7%, Japanese series). VETC was significantly associated with several clinical and pathological features such as high alfa‐fetoprotein (AFP) level, tumor size greater than 5 cm, poor differentiation, macrotrabecular pattern, less compact pattern, less inflammatory infiltrates, and frequent microvascular invasion. VETC was associated with early recurrence (hazard ratio [HR]: 1.52 [1.06‐2.19], P = 0.023), disease‐free survival (HR: 1.66 [1.21‐2.27], P = 0.002), and overall survival (HR: 2.26 [1.37‐3.72], P = 0.001) at multivariable analysis. VETC affected the survival in HCC patients stratified for etiology (hepatitis C virus/hepatitis B virus), vascular invasion, and specific molecular phenotypes (β‐catenin/GS+). This distinct vascular pattern was enriched in the recently reported macrotrabecular massive HCC subtype, which was seen in 7.8% (42 of 541) of patients and associated with high AFP levels and poor differentiation. Conclusion: The VETC pattern was found to be easily detectable in a consistent fraction of HCC and a powerful pathological finding affecting survival. This study suggests that the heterogeneous pattern of angiogenesis is involved in HCC behavior.
Randomized feasibility study of suction‐tube uterine tamponade for postpartum hemorrhage
Authors: Hofmeyr G. Justus , Middleton Katrin , Singata‐Madliki Mandisa 
Published: June 2019

AbstractObjectiveTo identify an inexpensive catheter suitable for uterine suction tamponade (UST) for postpartum hemorrhage and assess its functionality.MethodsRandomized, single‐center, double‐blind feasibility study in East London, South Africa, among 45 women undergoing cesarean delivery between October and November 2018. A search of medical supply websites for catheters with predefined characteristics (inexpensive, flexible, wide‐bore, circumferentially‐arranged side apertures, rounded tip) identified the FG36 Levin stomach tube. During cesarean, the tube was placed in the uterus and connected transvaginally to a suction unit. Participants were randomized via a computer‐generated random sequence to early (after uterine closure; n=24) or delayed (after skin closure; n=21) UST.ResultsThe tube functioned well with respect to stability in the uterus and aspirating blood from the uterine cavity without blockage. Blood loss was similar between the groups (mean difference, 7.3 mL; 95% confidence interval, −61 to 75; P=0.433), as were secondary outcomes. There were no complications. Absolute effectiveness was not tested because there was no non‐suction group.ConclusionThe FG36 Levin tube was found to be a suitable device for “suction‐tube uterine tamponade”. There was no difference in functionality between early and late UST. Future trials should assess the effectiveness of this approach for postpartum hemorrhage.Clinical trial registration: Registered in the Pan African Clinical Trial Registry as PACTR201809584199573.
Rare case of Richter syndrome with testicular involvement successfully obtained good prognosis with rapid operation and immunochemotherapy
Authors: Kawase Kengo , Naiki Taku , Naiki‐Ito Aya , Yanada Masamitsu , Ikegami Yosuke , Ota Yuya , Hattori Tatsuya , Matsuyama Nayuka , Hamakawa Takashi , Maruyama Tetsuji , Yasui Takahiro 
Published: June 2019

IntroductionRichter syndrome refers to the transformation from chronic lymphocytic leukemia to assaultive lymphoma, often a diffuse large B‐cell lymphoma, and has a greatly poor prognosis. Richter syndrome is characterized by rapidly growing lymphadenopathy but rarely presents with extra‐nodal involvement, common sites being the digestive tract, lungs, kidneys, and central nervous system. However, Richter syndrome with testicular involvement is extremely rare.Case presentationHerein we report a very scare case of a male at the age of 72 with Richter syndrome and testicular involvement, diagnosed by the investigation of bilateral scrotal swellings. The patient had attained disease‐free survival for over a year with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, and the intrathecal administration of chemotherapeutic agents after diagnosis by immediate orchiectomy.ConclusionAn early pathological diagnosis by immediate orchiectomy and the early initiation of induction immunochemotherapy may be good prognostic factors in Richter syndrome involving the testes.
An evolving tale of two interacting RNAs—themes and variations of the T‐box riboswitch mechanism
Authors: Suddala Krishna C. , Zhang Jinwei 
Published: June 2019

AbstractT‐box riboswitches are a widespread class of structured noncoding RNAs in Gram‐positive bacteria that regulate the expression of amino acid‐related genes. They form negative feedback loops to maintain steady supplies of aminoacyl‐transfer RNAs (tRNAs) to the translating ribosomes. T‐box riboswitches are located in the 5′ leader regions of mRNAs that they regulate and directly bind to their cognate tRNA ligands. T‐boxes further sense the aminoacylation state of the bound tRNAs and, based on this readout, regulate gene expression at the level of transcription or translation. T‐box riboswitches consist of two conserved domains—a 5′ Stem I domain that is involved in specific tRNA recognition and a 3′ antiterminator/antisequestrator (or discriminator) domain that senses the amino acid on the 3′ end of the bound tRNA. Interaction of the 3′ end of an uncharged but not charged tRNA with a thermodynamically weak discriminator domain stabilizes it to promote transcription readthrough or translation initiation. Recent biochemical, biophysical, and structural studies have provided high‐resolution insights into the mechanism of tRNA recognition by Stem I, several structural models of full‐length T‐box‐tRNA complexes, mechanism of amino acid sensing by the antiterminator domain, as well as kinetic details of tRNA binding to the T‐box riboswitches. In addition, translation‐regulating T‐box riboswitches have been recently characterized, which presented key differences from the canonical transcriptional T‐boxes. Here, we review the recent developments in understanding the T‐box riboswitch mechanism that have employed various complementary approaches. Further, the regulation of multiple essential genes by T‐boxes makes them very attractive drug targets to combat drug resistance. The recent progress in understanding the biochemical, structural, and dynamic aspects of the T‐box riboswitch mechanism will enable more precise and effective targeting with small molecules. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1167–1180, 2019
Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis
Authors: Chen Gao , Wu Mengzheng , Wu Bibo , Liu Feifei , Liu Jianying , Liu Li 
Published: June 2019

AbstractBackgroundTo investigate the effects of dual plasma molecular adsorption system (DPMAS) on the liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis (CSH).MethodsTotal of 162 patients with CSH treated in our hospital from March 2016 to December 2018 were enrolled and equally randomly divided into control group (n = 81) and observation group (n = 81). The patients in control group were treated with plasma exchange, while those in observation group were additionally treated with DPMAS based on the treatment in control group. The liver function, electrolytes, inflammation, and immunity were evaluated and compared between the two groups.ResultsAfter treatment, the liver function indexes in observation group were significantly favorable compared with those in control group, with the reduction in TBIL, DBIL, ALT, and rise of CHE levels (P < 0.05). The levels of K+, Na+, Cl−, and Ca2+ in both groups were significantly improved after treatment (P < 0.05), although there were no significant differences between the two groups (P > 0.05). The levels of C‐reactive protein (CRP), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) in both groups declined after treatment compared with those before treatment, and those levels in observation group were higher than that in control group (P < 0.05). After treatment, the levels of cluster of differentiation 3+ (CD3+), CD4+, and CD4+/CD8+ were higher in observation group than those in control group, with decreasing level of CD8+ (P < 0.05).ConclusionDual plasma molecular adsorption system can effectively improve the liver function, effectively correct the electrolyte disorders, reduce the inflammatory response, and adjust the immunity in patients with CSH.
Control of specific growth rate for the enhanced production of human interferon α2b in glycoengineered Pichia pastoris: process analytical technology guided approach
Authors: Katla Srikanth , Mohan Naresh , Pavan Satya S , Pal Uttariya , Sivaprakasam Senthilkumar 
Published: June 2019

AbstractBACKGROUNDProcess variability in bioprocess systems involving genetically engineered strains is a common bottleneck and a real‐time insight of the on‐going process is crucial to achieve the desired product and its quality. In this study, a process analytical technology (PAT) platform was developed for the monitoring and control of specific growth rate during methanol induction phase (μmet) of glycoengineered Pichia pastoris fermentation for human interferon alpha 2b (huIFNα2b) production.RESULTSThe PAT guided approach involves real‐time monitoring of capacitance (ΔC) facilitating online estimation of specific growth rate (μest), which serves as a process input during controller application. Fed‐batch experiments using pulsed‐feeding of methanol at different dosage (20 g and 30 g) did not significantly influence μmet. Exponential methanol feeding was achieved using a modified proportional, integral and derivative (PID) controller for different predefined specific growth rate set point (μsp) values, namely 0.015, 0.03, 0.04 and 0.06 h−1. Exponential feeding strategy during the induction phase resulted in two crucial outcomes: (i) controlled methanol feeding rate (regulated by the developed PID controller) balanced the methanol consumption rate (qs, met) of the P. pastoris; (ii) significant improvement in huIFNα2b titer (1483 mg L−1) and specific productivity(>0.4 mg g−1. h) was achieved by the robust control of μmet at optimal (0.04 h−1) value. The purified huIFNα2b was found to exhibit antiproliferative effect against human breast cancer cell lines.CONCLUSIONSEfficient control of μmet at a very low narrow range was achieved with a long‐term controller stability (>10 h) and the highest titer reported to date for huIFNα2b (at optimal μmet) in the yeast expression platform. © 2019 Society of Chemical Industry
Early inappropriate shock in a subcutaneous cardiac defibrillator due to subcutaneous air
Authors: Nishinarita Ryo , Kishihara Jun , Matsuura Gen , Arakawa Yuki , Kobayashi Shuhei , Shirakawa Yuki , Horiguchi Ai , Nakamura Hironori , Ishizue Naruya , Oikawa Jun , Fukaya Hidehira , Niwano Shinichi , Ako Junya 
Published: June 2019

AbstractA 57‐year‐old man was admitted to our hospital due to syncopal attack. He was diagnosed with Brugada syndrome due to which a subcutaneous implantable cardiac defibrillator (S‐ICD) was inserted using the standard technique. Two hours after the implantation, he experienced inappropriate shock while conscious. Device interrogation revealed a contentious baseline shift and frequent oversensing of low‐amplitude signals, which was followed by a shock. Lateral chest X‐ray revealed subcutaneous air surrounding the proximal electrode. Another inappropriate shock could be avoided by changing the sensing vector. The subcutaneous air was completely resolved 7 days after implantation.
Attribution theory: An introduction to the special issue
Authors: Martinko Mark J. , Mackey Jeremy D. 
Published: June 2019

SummaryThis special issue of the Journal of Organizational Behavior was developed to further extend attribution theory and its application to the field of organizational behavior. In this introduction, we provide a brief overview of the motivation for this special issue, a concise summary of the papers included in it, a discussion about progress toward the field's goals, and suggestions for how future research can move the field forward. In doing so, we describe how applying attribution theory to studies that utilize a broad range of study designs, research contexts, and focal topics results in insights that enhance our understanding of how attributional processes predict and explain individuals' emotions and behaviors. We also provide suggestions for how to further develop attribution theory so we can more clearly describe the generalizability of relationships across a wide variety of organizational contexts.
Temporal disparity of the atmospheric systems contributing to interannual variation of wintertime haze pollution in the North China Plain
Authors: Chen Shangfeng , Guo Jianping , Song Linye , Cohen Jason B. , Wang Yong 
Published: June 2019

AbstractPrevious studies indicated that the meridional (northerly or southerly) wind anomalies over East China play an important role in modulating interannual variation of the winter haze pollution in the North China Plain (NCP) mainly via changing surface wind speed and humidity. Here, we report that the factors for the formation of the meridional wind anomalies over East China related to interannual variation of winter haze pollution experienced a significant interdecadal change around the mid‐1990s. Before the mid‐1990s, two upstream atmospheric wave trains contribute to generation of the meridional wind anomalies over East China via inducing significant geopotential height anomalies over northeast Asia. The first occurred over mid‐latitude Eurasia and propagated eastward into East Asia, resembling the East Atlantic‐west Russia (EAWR) pattern. The second propagated eastward along the subtropical Asian jet. Furthermore, during this period, the change in the intensity of East Asian trough (EAT) was closely linked with interannual variation of the winter haze variation in the NCP. By contrast, after the mid‐1990s, the atmospheric wave train along the Asian subtropical jet was not observed. Furthermore, the connection between the EAT intensity and the winter time NCP haze variation was weak. The mid‐latitude EAWR‐like pattern and the El Niño‐Southern Oscillation‐related sea surface temperature anomalies in the tropical Pacific were possible factors that explain the meridional wind anomalies over East China. Understanding the change in the atmospheric anomalies contributing to interannual variation of the haze is essential for the prediction of haze in the NCP.
Diverse impacts of the Siberian high on surface air temperature in Northeast China during boreal winter
Authors: Liu Boqi , Zhu Congwen 
Published: June 2019

AbstractThe robust negative correlation between the Siberian High (SH) intensity and winter surface air temperature (SAT) in Northeast China has been widely used for winter climate seasonal forecasting. However, this traditional viewpoint varies when considering the changes in SH spatial extension during boreal winter. Here, a newly defined SH index representing both SH intensity and spatial extension shows two distinct influences of a stronger SH on the SAT in Northeast China. The stronger SH with a decreasing eastern edge, which features a meridional see–saw dipole of abnormal circulations centred over the Arctic and Siberia, respectively, results in a warmer winter over Northeast China. In this situation, the decreasing SH is linked to the enhanced Arctic Polar vortex through a tropospheric–stratospheric interaction. However, a stronger SH with an expanding eastern edge is coupled with the East Asian trough (EAT) and results in a colder winter in Northeast China. The SH and EAT anomalies are embedded in a zonally oriented wave‐train originating from the North Atlantic in the troposphere. Because of the diversity of impacts, the SH intensity and zonal extension should be jointly considered for seasonal forecasting of winter SAT anomalies in Northeast China.
Early Changes in Cement–Bone Fixation Using a Novel Rat Knee Replacement Model
Authors: Mann Kenneth A. , Miller Mark A. , Amendola Richard L. , Cyndari Karen I. , Horton Jason A. , Damron Timothy A. , Oest Megan E. 
Published: June 2019

ABSTRACTTrabecular resorption from interdigitated regions between cement and bone has been found in postmortem‐retrieved knee replacements, but the viability of interdigitated bone, and the mechanism responsible for this bone loss is not known. In this work, a Sprague–Dawley (age 12 weeks) rat knee replacement model with an interdigitated cement–bone interface was developed. Morphological and cellular changes in the interdigitated region of the knee replacement over time (0, 2, 6, or 12 weeks) were determined for ovariectomy (OVX) and Sham OVX treatment groups. Interdigitated bone volume fraction (BV/TV) increased with time for Sham OVX (0.022 BV/TV/wk) and OVX (0.015 BV/TV/wk) group, but the rate of increase was greater for the Sham OVX group (p = 0.0064). Tissue mineral density followed a similar increase with time in the interdigitated regions. Trabecular resorption, when it did occur, started at the cement border with medullary‐adjacent bone in the presence of osteoclasts. There was substantial loss of viable bone (~80% empty osteocyte lacunae) in the interdigitated regions. Pre‐surgical fluorochrome labels remained in the interdigitated regions, and did not diminish with time, indicating that the bone was not remodeling. There was also some evidence of continued surface mineralization in the interdigitated region after cementing of the knee, but this diminished over time. Statement of clinical significance: Interdigitated bone with cement provides mechanical stability for success of knee replacements. Improved understanding of the fate of the interdigitated bone over time could lead to a better understanding of the loosening process and interventions to prevent loss of fixation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2163–2171, 2019
Spatiotemporal Distribution of Linear Microcracks and Diffuse Microdamage Following Daily Bouts of Fatigue Loading of Rat Ulnae
Authors: Liu Xiyu , Tang Chi , Zhang Xuhui , Cai Jing , Yan Zedong , Xie Kangning , Yang Zhiping , Wang Jing , Guo X. Edward , Luo Erping , Jing Da 
Published: June 2019

ABSTRACTMicrodamage accumulation contributes to impaired skeletal mechanical integrity. The bone can remove microdamage by initiating targeted bone remodeling. However, the spatiotemporal characteristics of microdamage initiation and propagation and their relationship with bone remodeling in response to fatigue loading, especially for more physiologically relevant daily bouts of compressive loading, remain poorly understood. The right forelimbs of 24 rats were cyclically loaded with a ramp waveform for 1,500 cycles/day, and contralateral ulnae were not loaded as the controls. The rats were divided into four equal groups and loaded for 1, 4, 7, and 10 days, respectively. We demonstrated that linear microcracking accumulation exhibited a non‐linear time‐varying process within 10 days of loading with peaked microcrack density at Day 7. Disrupted canaliculi surrounding linear microcracks showed high similarity with the temporal changes of linear microcracking accumulation. Observable intracortical resorption regions were found on Day 10. We found more linear microcracks accumulated in the tensile cortex, but longer cracks were observed in the compressive sides. Increased accumulation of diffuse microdamage was observed from Day 4, but no obvious peak was observed within the 10‐day loading period. Diffuse damage first initiated in the compressive cortices but extended to tension from Day 7. The diffuse damage exhibited no impacts on the surrounding osteocyte integrity. Together, our findings revealed a time‐dependent, bone remodeling‐mediated varying process of linear microcracking accumulation following daily bouts of fatigue loading (with observable peak at Day 7 under our loading regime). Our study also identified distinct spatial accumulation of linear and diffuse microdamage in rat ulnae with tensile and compressive strains. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2112–2121, 2019