bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes et croyances soignantes envers des aînés mésusant d’alcool : enquête hospitalière par questionnaire auprès de 315 agents
Authors: Menecier Pascal , Fernandez Lydia , Pichat Michael , Ploton Louis 
Published: October 2018

Le mésusage d’alcool de sujets âgés est peu considéré, bien que sa prévalence ne décroisse que peu avec l’âge. Ce décalage peut autant relever de difficultés de repérage que de difficultés de prise en considération, possiblement reliées à des attitudes soignantes peu favorables. Afin d’évaluer les croyances et attitudes de soignants hospitaliers envers des sujets âgés mésusant d’alcool et préciser les variables qui les modulent, une enquête par questionnaire a été menée auprès de 698 médecins et infirmiers de 8 établissements de santé, à propos de leurs représentations, attitudes et connaissances autour du mésusage d’alcool après 65 ans. Les 315 questionnaires exploités (taux de réponse : 45 %), retrouvent que plus de 90 % des agents déclarent soigner des aînés mésusant d’alcool. Les soignants se disent alors majoritairement (75 %) à l’écoute ou disponible, 39 % aidants ou compétant, 32 % mal à l’aise, évitant ou fuyant, et 7 % agressifs, répressifs ou moralisateurs. Les déclarations d’abord positives sont ensuite remises en cause au fil des réponses et recoupements. Les attitudes les plus positives sont associées aux meilleurs niveaux de connaissance, aux expériences d’avoir côtoyé un proche mésusant d’alcool ou d’être soi-même consommateur d’alcool.
« Il arrivera comme les autres mais pas par le chemin de tout le monde »
Authors: Bourjot Aline 
Published: October 2018

« Il arrivera comme les autres mais pas par le chemin de tout le monde. » C’est par ces mots que la mère de Claude, petit garçon présentant des traits autistiques, a soutenu le cheminement de son enfant. Le cas dépliera le parcours de Claude pour sortir de l’enfermement où l’avait plongé un traumatisme précoce. Animé par sa propre ambition de grandir et soutenu par celle de sa mère qui lui reconnaît sa singularité (alors que l’autre le trouve souvent « particulier »), Claude nous mettra en position d’être le guide qui le suit dans son cheminement vers le symbolique.
Prolongements d’ambitions, de mère en fille
Authors: Morel Geneviève 
Published: October 2018

Bafouer l’ambition maternelle qui l’enferme dans un carcan, pour l’une ; vivre le rêve deviné de sa mère, tôt disparue, pour une autre. À travers témoignages cliniques, films et littérature, nous interrogeons les avatars de l’ambition féminine à différentes époques et montrons comment les filles déjouent/rejouent les plans de leur mère pour le meilleur ou pour le pire. Nous nous appuyons notamment sur le concept du surmoi et sur la notion de « prolongement du symptôme » (Lacan).
Source contributions and potential reductions to health effects of particulate matter in India
Authors: Guo Hao , Kota Sri Harsha , Chen Kaiyu , Sahu Shovan Kumar , Hu Jianlin , Ying Qi , Wang Yuan , Zhang Hongliang 
Published: October 2018

Abstract. Health effects of exposure to fine particulate matter (PM2.5) in India
were estimated in this study based on a source-oriented version of the
Community Multi-scale Air Quality (CMAQ) model. Contributions of different
sources to premature mortality and years of life lost (YLL) were quantified
in 2015. Premature mortality due to cerebrovascular disease (CEVD) was the
highest in India (0.44 million), followed by ischaemic heart disease (IHD,
0.40 million), chronic obstructive pulmonary disease (COPD, 0.18 million), and
lung cancer (LC, 0.01 million), with a total of 1.04 million deaths. The
states with highest premature mortality were Uttar Pradesh (0.23 million),
Bihar (0.12 million), and West Bengal (0.10 million). The highest total YLL
was 2 years in Delhi, and the Indo-Gangetic plains and eastern India had
higher YLL (∼1 years) than other regions. The residential
sector was the largest contributor to PM2.5 concentrations
(∼40 µg m−3), total premature mortality (0.58
million), and YLL (∼0.2 years). Other important sources
included industry (∼20 µg m−3), agriculture
(∼10 µg m−3), and energy (∼5 µg m−3) with their national averaged contributions of 0.21, 0.12, and 0.07
million to premature mortality, and 0.12, 0.1, and 0.05 years to YLL.
Reducing PM2.5 concentrations would lead to a significant
reduction of premature mortality and YLL. For example, premature mortality in
Uttar Pradesh (including Delhi) due to PM2.5 exposures would be reduced
by 79 % and YLL would be reduced by 83 % when reducing PM2.5
concentrations to 10 µg m−3.
Uma Ontologia para Computação Quântica
Authors: Pires José Carlos Puiati , Vizzotto Juliana Kaizer 
Published: October 2018

A computação quântica se apresenta atualmente como um novo paradigma computacional em relação à proposta de computação tradicional. Nela a representação de informação e evolução de um sistema computacional são diferentes. Apesar de um grande estudo sobre ela, ainda não foi proposto um modelo de conhecimento que descreva a computação quântica. Em busca disso, o seguinte trabalho apresenta uma ontologia em OWL, esta é modelada para incluir as principais características da computação quântica, fornecendo uma versão de conhecimento para esse domínio específico.
Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex
Authors: Pereira Catia M. , Freire Marco Aurelio M. , Santos José R. , Guimarães Joanilson S. , Dias-Florencio Gabriella , Santos Sharlene , Pereira Antonio , Ribeiro Sidarta 
Published: October 2018

BackgroundHistorically, the primary sensory areas of the cerebral cortex have been exclusively associated with the processing of a single sensory modality. Yet the presence of tactile responses in the primary visual (V1) cortex has challenged this view, leading to the notion that primary sensory areas engage in cross-modal processing, and that the associated circuitry is modifiable by such activity. To explore this notion, here we assessed whether the exploration of novel objects in the dark induces the activation of plasticity markers in the V1 cortex of rats.MethodsAdult rats were allowed to freely explore for 20 min a completely dark box with four novel objects of different shapes and textures. Animals were euthanized either 1 (n = 5) or 3 h (n = 5) after exploration. A control group (n = 5) was placed for 20 min in the same environment, but without the objects. Frontal sections of the brains were submitted to immunohistochemistry to measure protein levels of egr-1 and c-fos, and phosphorylated calcium-dependent kinase (pCaKMII) in V1 cortex.ResultsThe amount of neurons labeled with monoclonal antibodies against c-fos, egr-1 or pCaKMII increased significantly in V1 cortex after one hour of exploration in the dark. Three hours after exploration, the number of labeled neurons decreased to basal levels.ConclusionsOur results suggest that non-visual exploration induces the activation of immediate-early genes in V1 cortex, which is suggestive of cross-modal processing in this area. Besides, the increase in the number of neurons labeled with pCaKMII may signal a condition promoting synaptic plasticity.
Iron(III)‐Promoted Synthesis of 3‐(Organoselanyl)‐1,2‐Dihydroquinolines from Diorganyl Diselenides and N‐Arylpropargylamines by Sequential Carbon‐Carbon and Carbon‐Selenium Bond Formation
Authors: Goulart Tales A. C. , Kazmirski João A. G. , Back Davi F. , Zeni Gilson 
Published: October 2018

AbstractThe iron‐promoted tandem cyclization‐functionalization reaction of N‐arylpropargylamines with diorganyl diselenides was developed for the preparation of 3‐(organoselanyl)‐1,2‐dihydroquinolines. The best result was obtained when the reaction of N‐arylpropargylamines was carried out by the combination of diorganyl diselenides with FeCl3 ⋅ 6H2O in nitromethane at 70 °C. The control experiments strongly support the cooperative relation between the iron salts and diorganyl diselenides and their high reactivity not only to promote the cyclization but also to introduce a functionalization at the 3‐position of dihydroquinolines. The results indicate the existence of an iron/diorganyl diselenide complex, which forms both a cation and an anion of organoselenyl. In an attempt to prove the synthetic application of 3‐(organoselanyl)‐1,2‐dihydroquinolines prepared, we evaluated their use as substrates in the transition metal‐catalyzed cross‐coupling reactions with nucleophiles, such as boronic acids.magnified image
Pd‐Catalyzed One‐Pot Insertion Reaction of Cyclic C‐Acylimines into Carbon‐Carbon σ‐Bonds for the Synthesis of Polyfunctional Indolin‐3‐ones from 2‐Alkynyl Arylazides and Aryl Ketones
Authors: Li Ping , Yong Wanxiong , Sheng Rong , Rao Weidong , Zhu Xinbao , Zhang Xiaoxiang 
Published: October 2018

AbstractA method to prepare polyfunctional indolin‐3‐ones by Pd‐catalyzed one‐pot insertion reaction of cyclic C‐acylimines into carbon‐carbon σ‐bonds is described. The reaction was accomplished in good to excellent yields under mild reaction conditions.magnified image
Thermoplasmonic Response of Semiconductor Nanoparticles: A Comparison with Metals
Authors: Thakore Vaibhav , Tang Janika , Conley Kevin , Ala‐Nissila Tapio , Karttunen Mikko 
Published: October 2018

AbstractA number of applications in nanoplasmonics utilize noble metals, gold (Au) and silver (Ag), as the materials of choice. However, these materials suffer from problems of poor thermal and chemical stability with significant dissipative losses under high‐temperature conditions. In this regard, semiconductor nanoparticles have attracted attention with their promising characteristics of highly tunable plasmonic resonances, low ohmic losses, and greater thermochemical stability. Here, the size‐dependent thermoplasmonic properties of semiconducting silicon and gallium arsenide nanoparticles are investigated to compare them with Au nanoparticles using Mie theory. To this end, experimentally estimated models of dielectric permittivity are employed. Among the various permittivity models for Au, the Drude–Lorentz (DL) and the Drude and critical points (DCP) models are further compared. Results show a redshift in the scattering and absorption resonances for the DL model while the DCP model presents a blueshift. A massive Drude broadening contributes strongly to the damping of resonances in Au nanoparticles at elevated temperatures. In contrast, the semiconductor nanoparticles do not exhibit significant deterioration in their scattering and absorption resonances at high temperatures. In combination with low dissipative damping, this makes the semiconductor nanoparticles better suited for high‐temperature applications in nanoplasmonics wherein the noble metals suffer from excessive heating.
A Nickel(II)‐Containing Vitamin B12 Derivative with a Cofactor‐F430‐type π‐System
Authors: Brenig Christopher , Prieto Lucas , Oetterli René , Zelder Felix 
Published: October 2018

AbstractF430 is a unique enzymatic cofactor in the production and oxidation of methane by strictly anaerobic bacteria. The key enzyme methyl coenzyme M reductase (MCR) contains a hydroporphinoid nickel complex with a characteristic absorption maximum at around 430 nm in its active site. Herein, the three‐step semisynthesis of a hybrid NiII‐containing corrinoid that partly resembles F430 in its structural and spectroscopic features from vitamin B12 is presented. A key step of the route is the simultaneous demetalation and ring closure reaction of a 5,6‐secocobalamin to metal‐free 5,6‐dihydroxy‐5,6‐dihydrohydrogenobalamin with cobaltocene and KCN under reductive conditions. Studies on the coordination chemistry of the novel compound support an earlier hypothesis why nature carefully selected a corphin over a corrin ligand in F430 for challenging nickel‐catalyzed biochemical reactions.
Identification and development of microsatellite markers in Hamamelis mollis (Hamamelidaceae)
Authors: Yin Qianyi , Huang Cuiying , Huang Yanshuang , Chen Sufang , Ye Huagu , Fan Qiang , Liao Wenbo 
Published: October 2018

Premise of the StudyHamamelis mollis (Hamamelidaceae) is a Tertiary relict species endemic to southern China. Polymorphic microsatellite markers were developed to reveal the genetic diversity of this species.Methods and ResultsThe genome of H. mollis was sequenced and de novo assembled into 642,351 contigs. A total of 72,097 paired primers were successfully designed from 80,282 simple sequence repeat (SSR) markers identified in 63,419 contigs. PCR amplification showed that 96 of the 136 synthesized primers could be successfully amplified, and 22 demonstrated polymorphism. The mean number of alleles, levels of observed heterozygosity, and levels of expected heterozygosity were 4.602 ± 0.140, 0.632 ± 0.020, and 0.696 ± 0.010, respectively. The majority of the 96 primer pairs could be amplified in at least one other Hamamelidaceae species, including Distylium myricoides (60), Loropetalum chinense (39), Exbucklandia populnea (24), and E. tonkinensis (24).ConclusionsThese microsatellite loci provide abundant genomic SSR markers to evaluate genetic diversity of this woody ornamental plant.
Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement
Authors: Wang Wenjin , Degrugillier Lucas , Tremp Mathias , Prautsch Katharina , Sottaz Lima , Schaefer Dirk J. , Madduri Srinivas , Kalbermatten Daniel 
Published: October 2018

ABSTRACTSutureless nerve repair has been regarded as a promising technique for nerve repair as the suture materials often results in neuroma formation and scar tissue that impede nerve regeneration. The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic nerve, we tested the following experimental conditions: conventional suture repair; single suture combined with fibrin glue repair, and fibrin conduit reinforced with modified suture or fibrin glue. Nerve detachment anatomical measures such as axon density, myelin, and fiber caliber were analyzed for evaluation of nerve regeneration. Muscle atrophy were evaluated by muscle wet weight and H&E staining. All animals in sutureless repair group exhibited complete detachment or elongation by two or four weeks after repair. No detachment was found in any other groups. Animals treated with fibrin conduit reinforced with modified suture showed better axonal regeneration with good alignment. There were no significant differences in axon caliber among the groups. Muscle atrophy was found in all groups and there was no significant difference in muscle wet‐weight among the groups. In summary, sutureless nerve repair with fibrin glue was mechanically unstable for resistance of mechanical stretches, fibrin glue conduit with modified suture placement is mechanically stable and resulted in better morphological outcome. Anat Rec, 301:1690–1696, 2018. © 2018 Wiley Periodicals, Inc.
Design of a touch sensation application including surface tension sample using a haptic device in engineering education
Authors: Ustunel Hakan , Keles Fatih 
Published: October 2018

AbstractThis paper illustrates the effects of force feedback haptic applications as an educational material on the attitudes of students in engineering education. For this purpose, a simulation design has been carried out on a surface tension subject from physical chemistry. The availability of haptic devices in educational environments has accelerated. Although surface tension occurs at the atomic and molecular levels, the effects can be seen and the results are noticeable in daily life. These and similar applications make it necessary for this to be used as educational material by modeling and simulating small scale events such as surface. The aim of this study is to reach the conclusion that the haptic simulations that take place outside the scale of our daily lives (micro & macro) have a positive effect on the attitudes of students. It is also one of the expected results that the measurement values related to the research subject are proportionally transferred to the haptic device, consistently. In this application, a haptic device and its supporting application programming interfaces (API) for render operations have been used. A sample consisting of 48 engineering students has been divided into survey and control groups. While the survey group was working with the haptic application, the control group worked with conventional teaching methods. The data obtained from the sample have been analysed statistically, and the results have been evaluated. The findings of the research show that the survey group had a more positive attitude towards the haptic applications than the control group.
Long term explant culture for harvesting homogeneous population of human dental pulp stem cells
Authors: Patil Vikrant R. , Kharat Avinash H. , Kulkarni Deepak G. , Kheur Supriya M. , Bhonde Ramesh R. 
Published: October 2018

AbstractDental pulp stem cells have emerged as a preferred source of mesenchymal stem cells, because of its easy availability and high stem cell content. Dental pulp is a specific fibrous tissue that contains heterogeneous populations of odontoblasts, fibroblasts, pericytes, progenitors, stem cells, leukocytes and neuronal cells. In this study, we propose sustained explant culture as a simple, economical and efficient process to isolate dental pulp stem cells from human Dental pulp Tissue. Historically explant cultures were used to get fibroblast cells from embryonic chick heart using plasma clot cultures. The subculture was performed by lifting mother explant (original explant) and grafting it in a new plasma clot. We modified this age old technique to suit the modern times. Here we demonstrate for the first time that the mother explant (E0) of human dental pulp tissue could be sub‐cultured consecutively seven times (E7) without displacement. This technique is highly reproducible and permits growth and proliferation of dental pulp stem cells yielding an enriched homogeneous mesenchymal stem cells population in the first passage itself as revealed by surface marker expression. These dental pulp stem cells exhibit differentiation into adipogenic, chondrogenic and osteogenic lineage revealing their mesenchymal stem cell nature. We propose that dental pulp stem cells isolated by sustained explant culture are phenotypically and functionally comparable to those obtained by enzymatic method. It is a simple, inexpensive and gentle method, which may be preferred over the conventional techniques for obtaining stem cells from other tissue sources as well especially in cases of limited starting material.
Dehydrogenative Silylation of Alcohols Under Pd‐Nanoparticle Catalysis
Authors: Pramanik Suman , Fernandes Anthony , Liautard Virginie , Pucheault Mathieu , Robert Frederic , Landais Yannick 
Published: October 2018

AbstractPd‐nanoparticle‐catalyzed dehydrogenative coupling between various hydrosilanes and alcohols was shown to provide silyl ethers in good and reproducible yields. The synthetic methodology is effective for a wide range of simple and bulky silanes and secondary alcohols, while keeping various other functional groups intact. The procedure also exhibits high selectivity for the silylation of primary versus secondary alcohols in 1,2‐diols, and allows the successive silylation of alkynols and hydrogenation of the triple bond to afford Z‐alkenols in good yields.
A Versatile Self‐Detoxifying Material Based on Immobilized Polyoxoniobate for Decontamination of Chemical Warfare Agent Simulants
Authors: Dong Jing , Lv Hongjin , Sun Xiangrong , Wang Yin , Ni Yuanman , Zou Bo , Zhang Nan , Yin Anxiang , Chi Yingnan , Hu Changwen 
Published: October 2018

AbstractA decontaminating composite, Mg3Al‐LDH‐Nb6, has been successfully prepared by immobilizing Lindqvist [H3Nb6O19]5− (Nb6) into a Mg3Al‐based layered double hydroxide (Mg3Al‐LDH). To our knowledge, this represents the first successful approach to the immobilization of polyoxoniobate. As a versatile catalyst, Mg3Al‐LDH‐Nb6 can effectively catalyze the degradation of both vesicant and nerve agent simulants by multiple pathways under mild conditions. Specifically, the sulfur mustard simulant, 2‐chloroethyl ethyl sulfide (CEES), is converted into the corresponding nontoxic 2‐chloroethyl ethyl sulfoxide (CEESO) by selective oxidation, whereas the Tabun (G‐type nerve agent) simulant, diethyl cyanophosphonate (DECP), and the VX (V‐type nerve agent) simulant, O,S‐diethyl methylphosphonothioate (OSDEMP), are detoxified through hydrolysis and perhydrolysis, respectively. A possible mechanism is proposed on the basis of control experiments and spectroscopic studies. The Mg3Al‐LDH‐Nb6 composite exhibits remarkable robustness and can be readily reused for up to ten cycles with negligible loss of its catalytic activity. More importantly, a protective “self‐detoxifying” material has easily been constructed by integrating Mg3Al‐LDH‐Nb6 into textiles. In this way, the flexible and permeable properties of textiles have been combined with the catalytic activity of polyoxoniobate to remove 94 % of CEES in 1 h by using nearly stoichiometric dilute H2O2 (3 %) as oxidant with 96 % selectivity.
Scalable Synthesis of Fe/N‐Doped Porous Carbon Nanotube Frameworks for Aqueous Zn–Air Batteries
Authors: Li Fuyun , Li Heng , Liu Xiaoxiao , Wang Libin , Lu Yue , Hu Xianluo 
Published: October 2018

AbstractAqueous Zn–air batteries are emerging to be ideal next‐generation energy‐storage devices with high safety and high energy/power densities. However, the rational design and fabrication of low‐cost, highly efficient, and durable electrocatalysts on the cathode side remain highly desired. Herein, template‐assisted, scalable Fe‐implanted N‐doped porous carbon nanotube networks (Fe–N–CNNs) have been synthesized based on an environmentally friendly template hydroxyapatite nanowires (HAP NWs). Thanks to the hierarchical meso/micropores, high specific surface area, and abundant active sites, the optimized Fe–N–CNNs exhibit excellent oxygen reduction activity. Furthermore, the Zn–air batteries based on the Fe–N–CNNs cathode deliver a high discharge voltage of 1.27 V at a current density of 20 mA cm−2 and a large peak power density of 202.2 mW cm−2. More far‐reaching, this HAP‐based template strategy opens a new avenue toward the mass production of efficient, cost‐effective electrocatalysts, and the Fe–N–CNNs with hollow interiors are expected to extend their other potential uses in energy storage, molecular sieves, adsorbents, and biomedical engineering.
Regiocontrolled and Stereoselective Syntheses of Tetrahydrophthalazine Derivatives using Radical Cyclizations
Authors: Zhang Wei , Mo Jia Yi , He Weiying , Kennepohl Pierre , Sammis Glenn M. 
Published: October 2018

AbstractTetrahydrophthalazine derivatives have found important applications in pharmaceutical research, but existing synthetic methods are unable to access them regio‐ and stereoselectively. Here, a new approach is presented that addresses these challenges by utilizing a 6‐endo‐trig radical cyclization in the key step. The desired tetrahydrophthalazines can be accessed in high yields (55–98 %) and high diastereoselectivities for the trans‐product (>95:5) starting either from readily accessible hydrazones, or from the corresponding aldehydes and substituted Boc‐hydrazides in a one‐pot process. The synthetic versatility of the tetrahydrophthalazine core was demonstrated by its straightforward conversion to dihydro‐phthalazines, phthalazines, or pyrazolo dione derivatives. Furthermore, the N−N bond was reduced to afford a new route to 1,4‐diamines.