bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Quinoa Seeds: LC–MS/MS and GC–MS/MS Approaches for Identifying a Nutrient‐Rich Functional Food in Alzheimer's and Diabetes Care
Authors: Çoban Furkan , Yuca Hafize , Aydın Bilge , Tosun Murat , Yazıcı Abdullah , Karakaya Songül , Tan Mustafa , Özer Hakan , Atila Alptuğ 
Published: November 2024

ABSTRACTQuinoa is a versatile, nutrient‐dense, gluten‐free pseudocereal, increasingly recognized for its potential health benefits, particularly in managing diabetes mellitus and Alzheimer's disease—two conditions with growing links. Recent research on 14 quinoa genotypes explored fatty oil composition and bioactive potential of quinoa extracts. Linoleic acid was predominant fatty acid (46.60%–56.33%), whereas alanine was the most concentrated amino acid across all active extracts (192.4887–1578.0355 nmol/mL). French Vanilla hexane extract exhibited the strongest α‐glucosidase inhibition (75.71%), with Santa Ana hexane extract showing the highest α‐amylase inhibition (28.58%). Additionally, Titicaca hexane extract displayed notable acetylcholinesterase inhibition (22.22%), and Moqu Arochilla methanol extract had the most potent butyrylcholinesterase inhibition (47.20%). Antioxidant assays revealed that Salcedo and French Vanilla extracts had exceptional 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activity, with positive correlations found between total phenolic content and antioxidant activity (DPPH, β‐carotene, FRAP). These findings emphasize quinoa's potential as a functional food, offering significant benefits for disease management.
Optimizing passive micromixers: Enhancing mixing efficiency through computational fluid dynamics and metaheuristic algorithms
Authors: Mustafa Md Gulam , Zunaid Mohammad , Gautam Samsher 
Published: November 2024

AbstractThis paper examines the optimization of micromixers, highlighting their essential role in improving the efficiency of chemical reactions and fluid mixing at a micro‐scale, and using metaheuristic algorithms for a novel passive micromixer featuring bends and twists with offsets. The twists and bends cause constant changes in the direction of liquid flow, leading to chaotic advection that enhances species mixing while minimizing pressure loss. Although increasing channel length generally improves mixing performance, the proposed design's performance was higher than the reference channel for Reynolds numbers (Re) greater than 100. Key findings include achieving an excellent mixing performance of 87.76% at a Reynolds number of 400, with a bend angle of 60° and a twist factor of 4. The Harris hawk optimization (HHO) algorithm proved the most effective for optimizing microfluidic channel designs. This approach offers significant advantages for cost‐effectively optimizing microfluidic channel designs.
Crystal Structure of Ritonavir Polymorphs I and II Revisited with the Application of NMR Crystallography
Authors: Szeleszczuk Łukasz , Gubica Tomasz , Maciej Pisklak Dariusz 
Published: November 2024

AbstractRitonavir, a protease inhibitor sold under the brand name Norvir®, is an antiviral medication that effectively targets the human immunodeficiency virus (HIV). Being probably the most important and best‐known example of the crystal polymorphism in the field of pharmaceutics, ritonavir has been extensively studied in the last 30 years, which eventually led to the discovery of its new polymorph, Form III, in 2023. So far, two crystal structures of both Forms I and II of ritonavir were deposited in CCDC database. The aim of this study was to revisit those crystal structures, using NMR crystallography by recording the 13C CP/MAS NMR spectra and performing GIPAW NMR calculations with CASTEP. The obtained results revealed the major discrepancies between the calculated and experimental NMR chemical shift values. Those differences were explained at the molecular level, as resulting from the differences in the experimentally determined and DFT‐optimized positions of some atoms, mostly those forming phenyl and thiazole rings. This work is an example of how NMR crystallography can be used to verify and improve the already published crystal structures.
Enhanced Cycling Performance of the LiNiO2 Cathode in Li‐Ion Batteries Enabled by Nb‐Based Surface Coating
Authors: Nascimento Nunes Barbara , Karger Leonhard , Zhang Ruizhuo , Kondrakov Aleksandr , Brezesinski Torsten 
Published: November 2024

AbstractLithium nickel oxide (LNO) is a promising cathode candidate in various next‐generation battery technologies. To increase its stability, doping and surface coating have become key strategies. Among various elements, niobium stands out for its dual role as an effective dopant and the advantages of its oxide phases as coatings. In this study, we explore Nb‐based coating of LNO, utilizing methods that minimize or eliminate solvent use. Additionally, the coated samples were treated at two different temperatures to study their effect on properties and electrochemical performance. Our results demonstrate that the coating process strongly affects the cell cyclability and further highlight the potential of Nb‐based protective coatings in enhancing LNO as a cathode active material for application in high‐energy‐density Li‐ion batteries.
A Stochastic Model to Predict Seed Dispersal in Linear and Stokes Waves
Authors: Chen Jun , Zeng Yuhong , Ren Junqing , Liu Xiaoguang 
Published: November 2024

ABSTRACTPlant cultivation is utilized in coastal ecological restoration to cope with shrinking wetlands, and, benefiting from hydrochory, disseminating indigenous plant seeds represents a high‐efficiency strategy. Random displacement model (RDM) is an efficient alternative to simulate seed dispersal progress via wave. Consequently, we investigated the effect of seed properties and wave characteristics on seeds motion in waves by RDM. Errors between the theoretical comprehensive longitudinal diffusion coefficient of the solute and the simulated one by RDM within an acceptable range indicate that the model is applicable for further simulation of particle dispersal in waves. Simulation results demonstrated that seeds with smaller size and density can transport farther in waves; larger wave heights, smaller water depths and longer wavelengths in linear waves and larger relative wave heights and smaller relative water depths in Stokes waves all promote longitudinally seed diffusion. Finally fitting formulas were proposed for the longitudinal propagation position (including mean and variance) of seed dispersal in linear and Stokes waves. Although this work can provide certain scientific guidance for the restoration of coastal vegetation ecology through natural colonization, there is still much work that needs to be conducted to further the research.
Analysis and Interpretation of Thermal Evolution Anomalies in Palaeozoic Source Rocks in the Southwestern Ordos Basin, China
Authors: Lu Tianao , Huang Junping , Zhang Yan , Wang Pan , Xu Yaohui , Su Kaiming 
Published: November 2024

ABSTRACTThe YT3 well in the southern section of the western margin of the Ordos Basin recently accessed oil reservoirs in the Palaeozoic Carboniferous Yanghugou Formation and Ordovician Wulalike Formation that were previously believed to be gas‐producing. However, the region is characterised by extensive faulting and complex geological phenomena. Additionally, the Wulalike Formation exhibits an anomaly: shallow burial depth and high maturity occur in the western region. This study assesses the maturity of source rocks using organic geochemical methods in typical Palaeozoic oil‐bearing strata of the region. PetroMod software simulations are employed to reconstruct the thermal evolution history of selected wells and seismic profiles, elucidating these maturity anomalies. The findings reveal a generally higher thermal maturity in the western part and lower in the eastern part of the study area. The Ro of the Wulalike Formation ranged from 1.08% to 2.03%, while that of the Yanghugou Formation ranged from 0.55% to 0.68%. Prior to the Jurassic, the western strata were buried at a greater depth than the eastern strata. The source rocks of the western Palaeozoic had already produced a significant amount of hydrocarbons, and at this time, the strata exhibited a monoclinic west‐low‐east‐high pattern. Hydrocarbons would have been transported eastward along the stratigraphic gradient and deposited in suitable traps. After the Jurassic, the western part of the study area underwent significant denudation due to the Yanshan Movement and a strong retrograde overturning effect, which resulted in a shallow burial depth and high maturity.
The Genesis and Circulation of Geothermal Water in the Riduo–Cuona Rift, Eastern Tibetan Plateau, Based on Hydrochemistry and Stable Isotopes Geochemistry
Authors: Liu Yunhe , Zhou Xiaocheng , Wang Sheng , Chen Zhe , He Miao , Tian Jiao , Li Ying , Zhu Xiaoyi , Liu Zhipeng , Lu Baolong , Huang Yi 
Published: November 2024

ABSTRACTStudying initial geothermal fluids and tectonic active zones is crucial for exploiting intermediate high‐temperature geothermal resources. This study aims to investigate the genesis, circulation and environmental implications of geothermal water in the Riduo–Cuona Rift (RCR) of the eastern Tibetan Plateau. By integrating hydrochemical analysis, stable isotope geochemistry (δ2H, δ18O and 87Sr/86Sr), and noble gas isotope characteristics, the research seeks to develop comprehensive geothermal circulation models in the RCR. (M1) The spatial distribution of geothermal waters near the molten magmatic domes indicated 87Sr/86Sr ranges consistent with those of the rock, respectively. The high Ca, Mg ‘hardness’ spring waters were attributed to strata surrounding the dome resulting from the last leaching, as confirmed by the estimated higher hydraulic head, mainly located in ‘immature water.’ (M2) The spatial distribution of geothermal waters corresponding to an orogenic belt revealed HCO3·SO4–Na as the dominant hydrochemical facies in the northern RCR. Research suggests that springs exhibit greater circulation depths and that spring solute SO4 is related to the Gangdise magmatic arc leaching. (M3) However, the active tectonic zone's springs 87Sr/86Sr (0.705763–0.709754) indicated evaporite characteristics. The thermal reservoir temperature in this structural junction zone is the highest (256.75°C–287.03°C). The high trace alkali element concentrations, particularly of B, F and As, exceeded the WHO guideline; the drainage system analysis indicates regional nonnegligible environmental risks in the Gudui. Establishing these models can clarify the relationships between geothermal fluids, tectonic structures and regional faults, providing insights into geothermal resource potential, environmental risks and possible strategies for sustainable resource exploitation in the region.
The risk factors and prognostic impact of different benign pathologic types of background endometrium surrounding endometrial polyps
Authors: Huang Jiezhuang , Li Yuxin , Chen Peiyue , Zhi Zhifu 
Published: November 2024

AbstractObjectiveThis retrospective study investigated the prognostic significance and risk factors of benign pathologic types of background endometrium surrounding endometrial polyps (EPs).MethodsWe assessed 206 patients who underwent hysteroscopic polypectomy and background endometrium biopsy. Patients were categorized into four groups based on the pathologic types of background endometrium: normal proliferative endometrium (NPE), polypoid hyperplastic endometrium (PHE), chronic endometritis (CE), and non‐atypical endometrial hyperplasia (NEH). We employed univariable comparisons and multivariable logistic regression analysis to identify risk factors of PHE, CE, and NEH compared to NPE. Abnormal uterine bleeding (AUB) and recurrence of EPs were monitored over a 12‐month postoperative follow‐up period.ResultsIndependent risk factors for EPs with a background of CE included a history of genital tract infection (OR = 8.88, 95% CI: 2.95–26.70, P = 0.000), adenomyosis (OR = 13.70, 95% CI: 3.38–55.52, P = 0.000), and hydrosalpinx (OR = 2.23, 95% CI: 1.59–54.09, P = 0.013). Age (OR = 1.18, 95% CI: 1.07–1.30, P = 0.001) and BMI (OR = 1.33, 95% CI: 1.11–1.61, P = 0.003) were significant risk factors for EPs with a background of NEH. Patients with PHE had higher recurrence rates of EPs following 12 months of follow‐up. Moreover, background endometrium types PHE, CE, and NEH were associated with poorer control of AUB.ConclusionOur study underscores the importance of examining the histopathologic characteristics of the background endometrium surrounding EPs, as these benign lesions significantly influence the recurrence and symptomatology of EPs.
Edge Intelligence Empowered English Speech Recognition in Portable Devices
Authors: Li Zhongmin , Huang Weiguo , Gu Cui 
Published: November 2024

ABSTRACTOnline education has greatly promoted English learning. However, many learners still meet difficulty in spoken English. With the fast development of computer science and artificial intelligence, especially natural language processing, online education is becoming more and more intelligent which can greatly assist learners to grasp English speaking skill thorough automatically English speech recognition. However, it is still a challenge task to implement English speech recognition in portable devices which has limited computing resources. In order to tackle this issue, this paper proposes to combine edge intelligence with cloud computing for mobile English speech recognition. First, the preprocessing and feature extraction part is deploy in the edge nodes, such as pad or smart phone. Second, a pretrained speech recognition model is deployed in the cloud server to avoid the limits of edge nodes. The features are sent from edge nodes to cloud server, while the pretrained speech model in the cloud server returns the results to edge nodes. The experiments and simulations demonstrate the proposed solution can adapt the edge nodes with limited resources.
A qualitative study of the experiences of patients with prostate cancer when receiving negative genetic results: “I still don't have a grasp of what it all means”
Authors: Zayhowski Kimberly , Wang Catharine , Nahorniak Mary , Loo Stephanie , Gignac Gretchen , Gunn Christine 
Published: November 2024

AbstractGermline genetic testing has been increasingly conducted for treatment implications in patients with prostate cancer due to the expansion of testing eligibility. Understanding patients' comprehension of genetic results is crucial for establishing effective result disclosure practices. This importance has grown due to the increasing prevalence of negative genetic results being conveyed via electronic communication and by providers without a genetics specialization. This study explores patients with prostate cancer's perceptions of genetic results communication. We analyzed 24 qualitative, semi‐structured interviews with patients with prostate cancer at an urban safety‐net hospital who had genetic results documented in their medical records. Interview questions focused on patient experiences with genetic referrals, genetic counseling, and genetic result disclosure. Audio recordings were professionally transcribed and analyzed by the study team utilizing an inductive thematic approach to generate themes from recurring codes. Of those who participated, 18 were interviewed in English, 5 in Spanish, and 1 in Haitian Creole. No participants reported having a pathogenic variant identified with genetic testing. Study participants identified a number of gaps in results communication which led to misconceptions regarding hereditary cancer risk. Three themes were generated: (1) Patients desired clear communication about the next steps after genetic testing, (2) Patients commonly experienced cognitive dissonance with negative genetic results given personal and family history of cancer, and (3) Patients felt reassurance from negative genetic results. This research suggests that maintaining conversations between patients and healthcare providers alongside the delivery of negative results assists in patient comprehension. Additionally, it is essential to evaluate the accessibility and appropriateness of notes and results sent to patients. Ultimately, understanding communication barriers in genetic results return is imperative in order to provide high‐quality genetic care.
長期間の呼吸管理および遷延する低血圧から診断に至ったACTH単独欠損症の1例(A case of isolated ACTH deficiency diagnosed after long–term respiratory management and persistent hypotension)
Authors: 慎太郎 古谷 , 治郎 神山 , 亘 多喜 , 大輔 山本 , 昌士 五木田 , 茂正 田口 , 和也 清田 
Published: November 2024

要旨ACTH単独欠損症（isolated ACTH deficiency: IAD）はホルモン欠乏により多彩な臨床症状を示す疾患である。今回，自己排痰できないほどの全身の筋力および咳嗽力の低下を来し，人工呼吸器離脱困難を契機にIADの診断に至った1例を経験したので報告する。症例は60歳の男性。食欲不振から体動困難となり，救急搬送された。脱水および急性腎障害の診断で入院となり，入院後，敗血症性ショックやたこつぼ型心筋症を併発して重症化した。気管挿管人工呼吸管理を行った後，人工呼吸器離脱困難が続き，低血圧も遷延した。神経筋疾患や内分泌疾患を疑い，精査し，IADの診断に至った。IADは既知の疾患であるものの，稀な疾患がゆえ，診断に難渋し治療開始が遅延することがある。救急領域では意識障害や気管挿管により病歴聴取が困難となるため，より診断に難渋する。筋力低下や体重減少などはpost intensive care syndrome / ICU–acquired weaknessの症状と類似することから，経時的に診断は困難となるため早期に鑑別に挙げ精査する必要がある。
覚知状況で比較した予期せぬ院内心停止患者の脳機能予後についての調査報告：単施設後ろ向き観察研究(Brain function prognoses of patients having unexpected in–hospital cardiac arrests subdivided according to circumstances of detection: A single–center, retrospective observational study)
Authors: 豊 齋藤 , 貴大 三吉 , 聡 鳥海 , 邦生 金尾 , 清継 田熊 
Published: November 2024

要旨【背景と目的】近年の院内心停止の生存率は改善が乏しいとされるが知見は十分でない。予期せぬ院内心停止の実態を明らかにすることを目的とし，どのような状況の院内心停止患者で予後が良いか，その覚知状況ごとの臨床的特徴・予後を調査した。【方法】2013年4月から10年間に川崎市立川崎病院に入院中に予期せぬ心停止となり院内救急対応システムにより心肺蘇生を受けたものを対象とした。心停止を覚知した経緯を評価し4群（病態悪化で対応中に心停止に移行した「対応群」，偶々訪室すると心停止であった「訪室群」，通常診療中に突然心停止となった「突然発症群」，心電図モニターで覚知した「モニター群」）に分け患者背景・転帰等を群間で比較した。【結果】138例が対象。対応群45例（32.6%），訪室群37例（26.8%），突然発症群26例（18.8%），モニター群30例（21.7%）。年齢，性別，除細動や体温管理療法実施率は有意差なし。心静止は訪室群で多く，無脈性電気活動は対応群で，心室細動 / 無脈性心室頻拍はモニター群で多い傾向あり。自己心拍再開率は群間で有意差なし。24時間生存率，30日間生存率は突然発症群とモニター群で高く，30日後脳機能予後は突然発症群とモニター群で良い傾向あり。【結語】モニターで覚知した院内心停止の予後は良好であり，院内急変対策では心電図モニタリングが有用である可能性がある。
糖尿病性ケトアシドーシスに合併した糖尿病性舞踏病の1例(A case of diabetic hemiballismus with diabetic ketoacidosis)
Authors: 隆文 清水 , 新介 大西 , 洋一 片山 , 慶介 江原 , 理 奈良 
Published: November 2024

要旨症例は84歳の女性。糖尿病治療の自己中断歴がある。来院数日前から左上下肢にふるえを認めていたが，来院当日には左上下肢を振り回すような粗大運動になっていたため当院に救急搬送された。来院時の血液検査で高血糖とケトン体陽性の所見を認め糖尿病性ケトアシドーシスと診断し，インスリン持続静注を開始して入院とした。脳CTでは右大脳基底核にわずかな高濃度領域を認め，MRIでは右大脳基底核にT1強調画像でわずかに高信号域，T2強調画像，拡散強調画像，T2*強調画像では低信号域を認めたため，左上下肢近位からの不随意運動と合わせて糖尿病性舞踏病と診断した。不随意運動に対してはハロペリドールを投与し，症状の改善を図った。第2病日には高血糖は改善したためインスリン持続静注を中止し，basal bolus therapyに変更した。不随意運動は経時的に改善し，第5病日には消失した。その後，血糖コントロールを行ったのち，第15病日に他院に転院となった。糖尿病性舞踏病は非ケトン性高血糖で発症することがあるという報告が多いが，ケトアシドーシスでの発症は稀である。また脳血管障害や肝性脳症など，救急外来で遭遇する頻度が高い疾患が鑑別疾患となるため，救急医が知っておくべき病態である。
Uncovering the Strategic Potential of Blockchain Technology Adoption: A Systematic Literature Review
Authors: Pooja Pooja , Chikhale Mayur M. , Dhir Sanjay 
Published: November 2024

ABSTRACTBlockchain technology adoption has gained significant attention from researchers due to its potential transformative impacts across various industries. This study aims to provide a comprehensive understanding of the adoption of blockchain technology and its strategic implications for firms. This paper uses bibliometric analysis to identify influential articles, journals, authors, countries, and the thematic focus of articles. Further, this paper uses the TCCM framework to identify frequently used theories, characteristics, contexts, and methodologies of blockchain adoption. The most popular research areas are supply chain, finance, banking, agriculture, and health care. This study has provided a novel understanding of the antecedents for adopting blockchain technology including technology‐specific, organization‐specific, environment‐specific, and psychological factors and its strategic outcomes. Blockchain adoption results in the achievement of competitive advantage, sustainable and superior performance, and the creation of new value for customers. Future researchers can gain an understanding of the existing trends and knowledge related to blockchain adoption with a strategic perspective. Specific research questions are framed to advance knowledge in this domain by future researchers. Further, a unique conceptual model a from strategic perspective is proposed, that can serve as a foundation for future empirical and theoretical analysis. Managers and practitioners should consider strategic antecedents associated with blockchain technology adoption to gain a competitive advantage.
The role of physical metallurgical relationships in enhancing alloy properties prediction and design: A case study on Q&P steel
Authors: Li Yong , Li Hua , Wang Chenchong , Jose Rivera‐Diaz‐del‐Castillo Pedro Eduardo 
Published: November 2024

AbstractTraditional alloy design typically relies on a trial‐and‐error approach, which is both time‐consuming and expensive. Whilst physical metallurgical (PM) models offer some predictive capabilities, their reliability is limited by errors accumulating across space scales. To address this, this study proposes a novel framework that combines PM knowledge graphs (PMKGs) with graph neural networks (GNNs) to predict the tensile properties of quenching and partitioning steels, using genetic algorithms for dual‐objective optimization. Compared to traditional artificial intelligence (AI) models, this framework shows significant advantages in predicting ultimate tensile strength (UTS) and total elongation (TEL) with higher accuracy and stability. Notably, the R2 for TEL prediction improved by approximately 15%. Furthermore, this framework successfully balances UTS and TEL, resulting in the design of alloys with superior overall properties. The designed alloys, with a composition of approximately 0.3 wt.% C, 3 wt.% Mn, 1.2 wt.% Si, and minor amounts of Cr and Al, achieve a UTS exceeding 1500 MPa and TEL near 20%, aligning with PM principles and validating the rationality and feasibility of this method. This study offers new insights into applying AI in complex multi‐objective alloy design, highlighting the potential of integrating expert knowledge with GNNs.
Sequencing, Task Failures, and Capacity When Failures Are Driven by a Non‐Homogeneous Poisson Process
Authors: Zhu Lingjiong , Paul Anand , Aytug Haldun 
Published: November 2024

ABSTRACTWe study the optimal sequencing of a batch of tasks on a machine subject to random disruptions driven by a non‐homogeneous Poisson process (NHPP), such that every disruption requires the interrupted task to be re‐processed from scratch, and partially completed work on a disrupted task is wasted. The NHPP models random disruptions whose frequency varies systematically with time. In general, the time taken to process a given batch of tasks depends on the order in which the tasks are processed. We find conditions under which the simplest possible sequencing rules—shortest processing time first (SPT) and longest processing time first (LPT)—suffice to minimize the completion time of a batch of tasks.