bluuebunny/crossref_metadata_2025_split huggingface dataset:
FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape
Authors: Klempner Samuel J. , Madison Russell , Pujara Vivek , Ross Jeffrey S. , Miller Vincent A. , Ali Siraj M. , Schrock Alexa B. , Kim Seung Tae , Maron Steven B. , Dayyani Farshid , Catenacci Daniel V.T. , Lee Jeeyun , Chao Joseph 
Published: June 2019

Abstract

Background
With the exception of trastuzumab, therapies directed at receptor tyrosine kinases (RTKs) in gastroesophageal adenocarcinomas (GEA) have had limited success. Recurrent fibroblast growth factor receptor 2 (FGFR2) alterations exist in GEA; however, little is known about the genomic landscape of FGFR2-altered GEA. We examined FGFR2 alteration frequency and frequency of co-occurring alterations in GEA.

Subjects, Materials, and Methods
A total of 6,667 tissue specimens from patients with advanced GEA were assayed using hybrid capture-based genomic profiling. Tumor mutational burden (TMB) was determined on up to 1.1 Mb of sequenced DNA, and microsatellite instability was determined on 95 or 114 loci. Descriptive statistics were used to compare subgroups.

Results
We identified a total of 269 (4.0%) FGFR2-altered cases consisting of FGFR2-amplified (amp; 193, 72% of FGFR2-altered), FGFR2-mutated (36, 13%), FGFR2-rearranged (re; 23, 8.6%), and cases with multiple FGFR2 alterations (17, 6.3%). Co-occurring alterations in other GEA RTK targets including ERBB2 (10%), EGFR (8%), and MET (3%) were observed across all classes of FGFR2-altered GEA. Co-occurring alterations in MYC (17%), KRAS (10%), and PIK3CA (5.6%) were also observed frequently. Cases with FGFR2amp and FGFR2re were exclusively microsatellite stable. The median TMB for FGFR2-altered GEA was 3.6 mut/mb, not significantly different from a median of 4.3 mut/mb seen in FGFR2 wild-type samples.

Conclusion
FGFR2-altered GEA is a heterogenous subgroup with approximately 20% of FGFR2-altered samples harboring concurrent RTK alterations. Putative co-occurring modifiers of FGFR2-directed therapy including oncogenic MYC, KRAS, and PIK3CA alterations were also frequent, suggesting that pretreatment molecular analyses may be needed to facilitate rational combination therapies and optimize patient selection for clinical trials.

Implications for Practice
Actionable receptor tyrosine kinase alterations assayed within a genomic context with therapeutic implications remain limited to HER2 amplification in gastroesophageal adenocarcinomas (GEA). Composite biomarkers and heterogeneity assessment are critical in optimizing patients selected for targeted therapies in GEA. Comprehensive genomic profiling in FGFR2-altered GEA parallels the heterogeneity findings in HER2-amplified GEA and adds support to the utility of genomic profiling in advanced gastroesophageal adenocarcinomas.
Analysis of Conceptual Understanding of Botany and Metacognitive Skill in Pre-Service Biology Teacher in Jakarta, Indonesia
Authors: RİSTANTO Rizhal , LESTARİ Puji , MİARSYAH Mieke 
Published: June 2019

The achievement of learning objective of Biology, especially Phanerogamic Botany requires several important aspects, namely conceptual understanding and metacognitive skill. Analysis of conceptual understanding of Botany and metacognitive skill is needed to know to what extent are both aspects of achieving the learning objectives. The research aims to know and analyze the conceptual understanding and metacognitive skill of college students to achieve course objectives. The research is conducted in July 2018 at the Universitas Negeri Jakarta in Phanerogamic Botany course Eudicot sub-course material with 77 students as sample. The research includes in quantitative research with descriptive approach. Results obtained are, among others, the mean of conceptual understanding of Botany and metacognitive skill is 63.07 and 50.15, respectively, which is low based on the achievement score. The analysis result indicates that conceptual understanding of Botany is considered as low due to the difficulty faced by students in finding an example for each clade and in understanding the scientific terms that are the base of the learning. Students, however, are able to apply the concept into problems faced and students’ metacognitive skill in student planning aspect is unable to arrange goals to be achieved, to prioritize the learning.
Proposal of Character and Moral Education for Gifted Young Scientists in Indonesia
Authors: UMAMI İda , GANİ A , WASKİTO Tejo 
Published: June 2019

Character education is aimed at achieving the five
goals. Firstly, it is to develop affective potency of the students in their
context as human and citizen inheriting their nation character values.
Secondly, it is to develop the noble habit and behavior which are in line with
the universal values and the nation religious tradition. Thirdly, it is to strengthen the students’
leadership and their sense of responsibility as to the next generation of the
nation. Fourthly, it is to develop the students’ competency so that they could
be autonomous, creative, and possess nationality insight. Finally, it is to
develop the school as a good learning environment so that it could support the
growth of honesty, creativity, and friendship with the pride of nationality and
dignity. The morality education, in turn, lead to a
holistic personality possessing a high moral standard in speech, action,
attitude, thought, feeling, work, and output which are in line with the
religious values, norms, and the noble moral of the nation.
EKSPLORASI KEGIATAN MAHASISWA DALAM ORGANISASI KEMAHASISWAAN DI DEPARTEMEN PENDIDIKAN TEKNIK MESIN UNIVERSITAS PENDIDIKAN INDONESIA
Authors: Arifin Asep M. , Kuswana Wowo S. , Permana Tatang 
Published: June 2019

Penelitian ini bertujuan untuk mengetahui kondisi organisasi HMM FPTK UPI berdasarkan perspektif anggota dan untuk mengetahui persentase pengaruh aktif berganisasi dengan nilai akademik. Kegiatan kemahasiswaan meliputi aspek pengetahuan keorganisasian, kepemimpinan, manajemen organisasi, cara pengambilan keputusan dan efek pada akademik. Penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Hasil penelitian menunjukkan bahwa kegiatan organisasi terhadap akademik tidak memberikan efek negatif. Adapun terjadi penurunan nilai akademik, bukan merupakan pengaruh dari kegiatan organisasi. Kegiatan organisasi terhadap nilai akademik berpengaruh positif.
PEMBERIAN REINFORCEMENT UNTUK MENINGKATKAN MOTIVASI, AKTIVITAS, DAN HASIL BELAJAR SISWA SMK PADA KOMPETENSI DASAR PEMELIHARAAN/SERVIS SISTEM KOPLING DAN KOMPONENNYA
Authors: Nurvalah Siti , Wiharna Ono , Yayat Yayat 
Published: June 2019

Tujuan penelitian ini untuk meningkatkan motivasi, akrivitas dan hasil belajar peserta didik Penelitian ini menggunakan metode Penelitian Tindakan Kelas yang dilaksanakan dalam dua siklus pada semester genap tahun pelajaran 2015/2016 dan dilakukan di kelas XI TKR 5 SMK Negeri 2 Garut. Instrumen penelitian yang digunakan adalah lembar angket, lembar observasi pelaksanaan pembelajaran, lembar observasi aktivitas belajar, dan lembar tes berupa pre-test dan post test. Hasil penelitian menunjukan bahwa terjadi peningkatan pada motivasi belajar dalam kategori sangat kuat, terjadi peningkatan pada aktivitas belajar dalam kategori sangat tinggi, dan terjadi peningakatan hasil belajar peserta didik (aspek kognitif dalam kategori amat baik, aspek psikomotor dalam kategori amat baik, dan aspek afektif dalam kategori sangat positif). Pemberian reinforcement dapat meningkatkan motivasi, aktivitas, dan hasil belajar peserta didik, terjadi karena pemberian reinforcement yang bervariasi; pemberian reinforcement diberikan dengan segera tanpa menunda; mengatur jadwal penguatan dan memberikan reinforcement tepat pada waktunya; pemberian reinforcement diberikan tepat sasaran; dan menghindari pemberian reinforcement negatif.
Penerapan Metode Pembelajaran Edutainment pada Pembelajaran Psychrometric untuk Meningkatkan Hasil Belajar Siswa SMK
Authors: Zakaria Asep , Sumardi Kamin , Berman Ega T 
Published: June 2019

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar dan aktivitas belajar siswa setelah menggunakan metode pembelajaran edutainment pada pembelajaran psychrometric. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas. Penelitian ini terdiri atas tiga siklus. Setiap siklus terdiri atas kegiatan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan datanya menggunakan soal pretest, posttest dan observasi. Hasil penelitian menunjukkan terjadi peningkatan hasil belajar siswa yang ditunjukkan oleh nilai rata-rata hasil belajar siswa pada siklus I adalah sebesar 74,4, pada siklus II sebesar 81,1, dan pada siklus III sebesar 85 dengan nilai rata-rata N-Gain siklus I adalah sebesar 0,6, siklus II sebesar 0,6, dan siklus III sebesar 0,7. Penerapan metode pembelajaran edutainment juga menyebabkan aktivitas belajar siswa meningkat pada setiap siklusnya. Hasil rata-rata persentase aktivitas belajar pada siklus I adalah sebesar 39,8%, siklus II sebesar 65,2%, dan siklus III sebesar 84,2%. Kesimpulan dari penelitian ini bahwa dengan menerapkan metode pembelajaran edutainment dapat meningkatkan hasil belajar dan aktivitas belajar siswa pada pembelajaran psychrometric.
Penerapan Model Pembelajaran Cooperative Learning Tipe Student Team Achievement Divisions dalam Upaya Meningkatkan Hasil Belajar Siswa
Authors: Amalia Siti , Ariyano Ariyano , Suherman Amay 
Published: June 2019

Tujuan penelitian ini untuk mengetahui pengaruh peningkatan hasil belajar yang dihasilkan dengan menerapkan model student team achievement division. Metode ini diterapkan pada mata pelajaran mekanika teknik dan elemen mesin Metode yang digunakan yaitu kuasi eksperimen dengan pendekatan kuantitatif dengan menjadikannya treatment untuk kelas eksperimen dan model pembelajaran konvensional untuk kelas kontrol. Pre test dilakukan sebelum kegiatan treatment dan post test dilakukan setelahnya. Maka nilai N-Gain yang didapatkan dari perhitungan skor pre test dan post test dijadikan data untuk uji hipotesis. Pengujian hipotesis menggunakan uji t dua arah. Hasil N-Gain kelas kontrol sebesar 56,27 sedangkan untuk kelas eksperimen nilai N-Gain sebesar 68,38. Hasil uji hipotesis menunjukkan nilai thitung sebesar 3,734 dan lebih besar dari ttabel dengan derajat kebebasan dk = 58 yaitu bernilai 2,00. Hal ini menunjukkan penolakan H0 dan penerimaan hipotesis alternatif yaitu terdapat pengaruh penerapan model pembelajaran student team achievement division terhadap peningkatan hasil belajar.
Hubungan Kesiapan Keluarga Dengan Kondisi Demensia Lansia
Authors: Sembiring Santa Theresia Handayani , Setyarini Elizabeth Ari 
Published: June 2019

ABSTRAKIndonesia adalah negara yang termasuk era penduduk berstruktur lansia karena jumlah penduduk yang berusia 60 tahun keatas sekitar 7,18%. Meningkatnya populasi lanjut usia ini menimbulkan berbagai perubahan yang berdampak pada masalah kesehatan, salah satunya adalah fungsi kognitif yaitu demensia. Penurunan fungsi kognitif ini menyebabkan lansia membutuhkan bantuan orang lain dalam aktivitasnya. Keluarga memiliki peran yang sangat penting dalam perawatan lansia demensia yang tinggal di rumah. Tujuan penelitian ini mengidentifikasi hubungan kesiapan keluarga dengan kondisi demensia lansia di Posbindu. Penelitian dengan metode kuantitatif dengan desain penelitian cross sectional dan total sampling yangdilaksanakan pada Bulan Mei - Juni 2017. Hasil uji Chi-Square diperoleh p-value = 0,896, hal ini berarti bahwa Ha ditolak sehingga tidak ada hubungan kesiapan keluarga dengan kondisi demensia lansia. Kesimpulan penelitian tidak ada hubungan kesiapan keluarga dengan kondisi demensia lansia di Posbindu RW 06 Cimareme. Rekomendasi penelitian adalah pentingnya kesiapan dan pendampingan keluarga dalam memberikan rasa nyaman dan aman pada lansia dalam keluarga. ABSTRACT Indonesia is a country which includes an era of Aging Structured Populationbecause the population aged 60 years and above is around 7.18%. The increase in the elderly population raises various changes that have an impact on health problems, one of which is cognitive function namely dementia. This decline in cognitive function causes the elderly to need help from others in their activities. Families have a very important role in the care of elderly dementiawho live at home. The purpose of this study was to identify the relations between family readiness with dementia conditions of the elderly at Subdistrict Center Health Care. The research with quantitative method with cross sectional and total sampling design was carried out from May to June 2017. The Chi-Square test results obtained p-value = 0.896, this means that Ha was rejected so there was no the relations between the relations between family readiness with dementia conditions of the elderly. The conclusion of the study was that there was no the relations between the relations between family readiness with dementia conditions of elderly at Subdistrict Center Health Care. Research recommendations are the importance of family readiness and assistance in providing a sense of comfort and safety to the elderly in the family.
Pelaksanaan Discharge Planning di Ruang ICU RS X Jakarta
Authors: Wulandari Dyah Fitri , Hariyati Rr. Tutik 
Published: June 2019

ABSTRAKDischarge planning merupakan suatu proses yang kompleks yang bertujuan untuk menyiapkan pasien dalam masa transisi di rumah sakit sampai pasien tersebut kembali ke rumahnya, dimana pelaksanannya harus dibuat sejak awal pasien datang ke pelayanan kesehatan. Pelaksanaan discharge planning di rumah sakit dilakukan sebelum pasien pulang, atau sebelum pasien keluar dari unit layanan Pengamatan yang dilakukan penulis terhadap pelaksanaan discharge planning di ruang ICU, perawat lebih mengutamakan memperhatikan kondisi kritis pasien, sehingga melupakan pelaksanaan discharge planning. Tujuan tulisan ini adalah melakukan analisis terhadap pelaksanaan discharge planning di ruang ICU RS X Jakarta. Metode yang digunakan adalah metode analisis dengan menggunakan fishbone dengan asesmen yang dilakukan berupa observasi, wawancara dan pengumpulan data sekunder yang sudah ada di RS X Jakarta, setelah itu dilakukan pencarian literatur untuk mengidentifikasi akar masalahnya, sehingga bisa diusulkan rekomendasi untuk penyelesaian terhadap masalah tersebut. Dari hasil analisis ditemukan akar masalah yaitu pengetahuan perawat yang kurang tentang discharge planning dan kurang optimalnya sistem yang mendukung pelaksanaan discharge planning seperti format, SPO dan panduan. Rekomendasi yang di usulkan yaitu berupa perbaikan format discharge planning, revisi SPO, pembuatan panduan dan pelaksanaan pelatihan discharge planning.ABSTRACTDischarge planning is a complex process that aims to prepare patients in the transition period in the hospital until the patient returns to his home, where the implementation must be made from the beginning the patient comes to the health service. However, discharge planning was done before the patient returns, or before the patient left the service unit in Hospital. In the ICU room with critical patient conditions, nurses prioritize paying attention to the critical condition of the patient, thus forgetting the implementation of this discharge planning. For this reason, this paper aimed to analyze the implementation of discharge planning in the ICU of Jakarta X Hospital, literature study to identify the root of the problem, so that recommendations can be proposed to resolve the problem. The method was used an analysis using fishbone diagram with an assessment conducted in the observation form. Interview and secondary data collection from Jakarta X Hospital. Based on the analysis results, the root cause of the problem is knowledge of nurses who are less about discharge planning and less optimal systems that support the implementation of discharge planning such as format, SPO and guidelines. For this reason, recommendations for improvements were made in the form of redesigning the format of discharge planning, revision of SPO, making guidelines and implementing discharge planning training
Late Middle and Early Upper Paleolithic of the Eastern Adriatic and the Problem of the Regional Middle/Upper Paleolithic Interface
Authors: Karavanić I. , Vukosavljević N. 
Published: June 2019

Eastern Adriatic Late Middle Paleolithic is relatively well known. On the other hand, Early Upper Paleolithic sites in the same region are scarce, and in particular the sites from Early Aurignacian, which are completely lacking. Sites with stratigraphy encompassing Late Middle Paleolithic and Early Upper Paleolithic that would signifi cantly contribute to better understanding of the Middle to Upper Paleolithic transition have not yet been found. In this paper, we give an overview of the archaeological record of the regional Late Middle and Early Upper Paleolithic from Croatia, Bosnia and Herzegovina, Montenegro and Albania. The information on research of Late Middle Paleolithic sites conducted in different regions of the eastern Adriatic (e.g., Mujina pećina and Velika pećina in Kličevica in Dalmatia, open-air site Campanož and Romualdova pećina in Istria, Bioče and Crvena stijena in Montenegro) is given. AMS and ESR dates give good temporal frame for Late Middle Paleolithic. Contrary to this, radiocarbon dates for Early Upper Paleolithic are scarce, and were made long time ago, hence bringing into question their reliability as is supported by their very late age for Aurignacian. Only one recent AMS date from Šandalja II could represent real Aurignacian age. According to current data, there is a hiatus of several thousand years between Late Middle and Early Upper Paleolithic in the eastern Adriatic. Here we suggest several potential reasons for such fragmentary record of the Middle to Upper Paleolithic transition in the eastern Adriatic.
“Taiga” and “River” Components in the Nanai Socio-Tribal Organization at Lake Bolon, the Lower Amur
Authors: Maltseva O. V. 
Published: June 2019

This study explores the socio-tribal organization of the Nanai living near Lake Bolon, with reference to environment and migration, using published and unpublished sources, S.K. Patkanov’s statistical materials, and our field data. We employ D.N. Anuchin’s spatial distribution and variation method for reconstructing the settlement pattern and assessing the socio-tribal structure with regard to the contacts between sedentary and nomadic populations. The Lake Bolon area is a transit territory traversed by reindeer herders and hunters on their way to the Pacifi c coast, and the place from whence the Amur natives migrated in various directions. This is where the herding, hunting, and fi shing traditions merged. The Nanai settlers selected places that matched their economic specialization, and these places eventually acquired symbolic functions. Small populations merged, adapted, and borrowed the names of large territorial groups. Marital contacts and kinship ties are analyzed in detail. Social relationships were regulated by the Dokha institute: clans concluded alliances based on mutual aid. Intermarriage was allowed only after several generations. The analysis of exogamous clans such as Hodzher, Odzyal, Kileh, and Beldy, which had settled near the lake, and the interviewing of the natives suggest that along with the Tungus patrilineal kinship, the matrilineal system predating the Tungus expansion was still practiced.
Epidemiology of Arterial Hypertension in Russian Federation – Importance of Choice of Criteria of Diagnosis
Authors: Erina A. M. , Rotar O. P. , Solntsev V. N. , Shalnova S. A. , Deev A. D. , Baranova E. I. , Konradi O. A. , Boytsov S. A. , Shlyakhto E. V. 
Published: June 2019

Purpose.Assessment of prevalence of arterial hypertension (AH), need for prescription of antihypertensive therapy (AHT), and efficacy of AHT in Russian population in accordance with novel guideline of the American College of Cardiology/American Heart Association (“American recommendations”) on diagnosis and treatment of AH (2017).Materials and methods. Epidemiological study ESSE-RF (ЭССЕ-РФ) was carried out in 12 regions of Russian Federation (RF) with different climatic-geographic characteristics. Number of examined residents of RF aged 25–65 years was 20 652. The sample was stratified by gender and age. Examination included anthropometry, laboratory tests, blood pressure (BP) measurement with the OMRON tonometer. The SCORE scale was used for evaluation of risk of development of cardiovascular diseases (CVD). In American recommendations AH was defined as follows: 1-st degree – systolic BP (SBP) 130–139 and/or diastolic BP (DBP) 80–89 mm Hg, 2-nd degree – BP ≥140/90 mm Hg and/or presence of AHT. In recommendations of the European Society of Cardiology (2013, 2018) (“European recommendations”) AH was defined as BP ≥140/90 mm Hg and/or presence of AHT.Results. We analyzed data of examination of 20 607 participants – 7806 men (37.9%) and 12 801 women (62.1%). According to European recommendations AH was diagnosed in 10 347 persons (50.2%) – 3987 men (51.1%) men and 6 360 women (49.7%). According to American recommendations AH was registered in 14 853 persons (72.1%) – 6 059 men (77.6%) and 8 794 women (68.7%). AHT received 6324 persons (61.1% of those with AH); according to American recommendations, the onset of AHT was indicated to additional 620 persons with 1-st degree AH because of high CVD risk. Among all participants with AH (on and without AHT) strengthening of AHT for achievement of target BP level was required in 77.8 and 92.6% of patients according to European and American recommendations, respectively.Conclusion. Application of novel criteria of AH diagnosis from 2017 ACC/AHA guideline to Russian population would increase prevalence of AH up to 72.1%. Onset of AHT would be indicated in 13.8% of patients with 1-st degree AH, while in 93% of patients receiving AHT its strengthening would be required.
Comorbidity of Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Place of Therapy with Modern β-Adrenoblockers
Authors: Belenkov Yu. N. , Tsvetkova O. A. , Privalova E. V. , An G. V. , Ilgisonis I. S. , Voronkova O. O. 
Published: June 2019

Chronic obstructive pulmonary disease (COPD) is the fourth largest cause of worldwide mortality. Presence of comorbidities is registered in 96% of COPD patients. The most important of these are cardiovascular diseases (coronary artery disease, arterial hypertension, chronic heart failure), which contribute to COPD patients’ mortality in every third case. COPD and cardiovascular diseases have common risk factors and pathogenesis mechanisms. Cardioselective beta-blockers reduce morbidity risk and frequency of COPD exacerbation, are effective and safe in treatment of COPD patients.