bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident
Authors: Poluben Larysa , Puligandla Maneka , Neuberg Donna , Bryke Christine R. , Hsu Yahsuan , Shumeiko Oleksandr , Yuan Xin , Voznesensky Olga , Pihan German , Adam Miriam , Fraenkel Ernest , Rasnic Roni , Linial Michal , Klymenko Sergiy , Balk Steven P. , Fraenkel Paula G. 
Published: October 2018

AbstractMyeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL, and CALR genes; however, 10%‐15% of cases are triple negative (TN). A previous study showed lower rate of JAK2 V617F in primary myelofibrosis patients exposed to low doses of ionizing radiation (IR) from Chernobyl accident. To examine distinct driver mutations, we enrolled 281 Ukrainian IR‐exposed and unexposed MPN patients. Genomic DNA was obtained from peripheral blood leukocytes. JAK2 V617F, MPL W515, types 1‐ and 2‐like CALR mutations were identified by Sanger Sequencing and real time polymerase chain reaction. Chromosomal alterations were assessed by oligo‐SNP microarray platform. Additional genetic variants were identified by whole exome and targeted sequencing. Statistical significance was evaluated by Fisher's exact test and Wilcoxon's rank sum test (R, version 3.4.2). IR‐exposed MPN patients exhibited a different genetic profile vs unexposed: lower rate of JAK2 V617F (58.4% vs 75.4%, P = .0077), higher rate of type 1‐like CALR mutation (12.2% vs 3.1%, P = .0056), higher rate of TN cases (27.8% vs 16.2%, P = .0366), higher rate of potentially pathogenic sequence variants (mean numbers: 4.8 vs 3.1, P = .0242). Furthermore, we identified several potential drivers specific to IR‐exposed TN MPN patients: ATM p.S1691R with copy‐neutral loss of heterozygosity at 11q; EZH2 p.D659G at 7q and SUZ12 p.V71 M at 17q with copy number loss. Thus, IR‐exposed MPN patients represent a group with distinct genomic characteristics worthy of further study.
Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis
Authors: Kutlar Abdullah , Kanter Julie , Liles Darla K. , Alvarez Ofelia A. , Cançado Rodolfo D. , Friedrisch João R. , Knight‐Madden Jennifer M. , Bruederle Andreas , Shi Michael , Zhu Zewen , Ataga Kenneth I. 
Published: October 2018

AbstractThe cell adhesion molecule P‐selectin plays a key role in the pathogenesis of a vaso‐occlusive crisis (VOC) in patients with sickle cell disease (SCD). In the double‐blind, placebo‐controlled phase 2 SUSTAIN study, crizanlizumab (humanized, anti‐P‐selectin monoclonal antibody) 5 mg/kg significantly lowered the rate of VOC in patients with SCD by 45% vs placebo. In SUSTAIN, patients with SCD were randomized to crizanlizumab 2.5 mg/kg, crizanlizumab 5 mg/kg, or placebo intravenously 14 times over 52 weeks. The primary endpoint was the annual rate of VOC with crizanlizumab vs placebo. This post hoc descriptive analysis evaluated the proportion of patients who did not experience a VOC during the study in the following subgroups: VOCs in the year prior to study entry (2‐4/5‐10), SCD genotype (HbSS/non‐HbSS), and concomitant hydroxyurea use (yes/no). More patients were VOC event‐free in the crizanlizumab 5 mg/kg arm than in the placebo arm, including those with more frequent prior VOCs (ie, 5‐10; 28.0% vs 4.2%), the HbSS genotype (31.9% vs 17.0%) and/or using concomitant hydroxyurea (33.3% vs 17.5%). Further analyses of secondary endpoints demonstrated that crizanlizumab treatment significantly increased time‐to‐first VOC vs placebo in these subgroups. The rates of treatment‐emergent adverse events were similar between treatment arms across all subgroups. This post hoc analysis of SUSTAIN shows that in patients with a high number of prior VOCs, on concomitant hydroxyurea and/or with the HbSS genotype, crizanlizumab treatment increases the likelihood of patients being VOC event‐free and delays time‐to‐first VOC.
N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
Authors: Karuppagounder Saravanan S. , Alin Lauren , Chen Yingxin , Brand David , Bourassa Megan W. , Dietrich Kristen , Wilkinson Cassandra M. , Nadeau Colby A. , Kumar Amit , Perry Steve , Pinto John T. , Darley‐Usmar Victor , Sanchez Stephanie , Milne Ginger L. , Pratico Domenico , Holman Theodore R. , Carmichael S. Thomas , Coppola Giovanni , Colbourne Frederick , Ratan Rajiv R. 
Published: October 2018

ObjectivesN‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an “antioxidant,” poor understanding of its site(s) of action is a barrier to its use in neurological practice. Here, we examined the efficacy and mechanism of action of NAC in rodent models of hemorrhagic stroke.MethodsHemin was used to model ferroptosis and hemorrhagic stroke in cultured neurons. Striatal infusion of collagenase was used to model intracerebral hemorrhage (ICH) in mice and rats. Chemical biology, targeted lipidomics, arachidonate 5‐lipoxygenase (ALOX5) knockout mice, and viral‐gene transfer were used to gain insight into the pharmacological targets and mechanism of action of NAC.ResultsNAC prevented hemin‐induced ferroptosis by neutralizing toxic lipids generated by arachidonate‐dependent ALOX5 activity. NAC efficacy required increases in glutathione and is correlated with suppression of reactive lipids by glutathione‐dependent enzymes such as glutathione S‐transferase. Accordingly, its protective effects were mimicked by chemical or molecular lipid peroxidation inhibitors. NAC delivered postinjury reduced neuronal death and improved functional recovery at least 7 days following ICH in mice and can synergize with clinically approved prostaglandin E2 (PGE2).InterpretationNAC is a promising, protective therapy for ICH, which acted to inhibit toxic arachidonic acid products of nuclear ALOX5 that synergized with exogenously delivered protective PGE2 in vitro and in vivo. The findings provide novel insight into a target for NAC, beyond the generic characterization as an antioxidant, resulting in neuroprotection and offer a feasible combinatorial strategy to optimize efficacy and safety in dosing of NAC for treatment of neurological disorders involving ferroptosis such as ICH. Ann Neurol 2018;84:854–872
Surface modification of polyamide reverses osmosis membrane by phosphonic acid group with improved performance
Authors: Zhao Yali , Dai Lei , Zhang Qifeng , Zhang Suobo 
Published: October 2018

ABSTRACTA facial method for preparing reverse osmosis polyamide (PA) membranes of excellent antifouling and separation performance was developed via covalently grafting phosphonic acid on membrane surface. First, a pristine PA layer was synthesized by interfacial polymerization between m‐phenylenediamine and trimesoyl chloride. Then, a second interfacial reaction was implemented between ethylenediamine and the residual acryl chloride on the pristine PA layer, generating an active layer enriched by primary amine. Finally, the amine‐rich surface treated by formaldehyde and phosphorous acid to produce a membrane surface modified by phosphonic acid groups. Surface characterization by attenuated total reflectance infrared, X‐ray photoelectron spectroscopy and zeta‐potential measurements illustrated the presence of phosphonic acid group. The lowest contact angle of modified membrane was 26°, demonstrating the membrane possessed an outstandingly wettable surface. The optimal separation performance was 88 L m−2 h−1 of water flux and 99.4% of salt rejection under 1.55 MPa. In addition, bovine serum albumin was used as organic foulant to measure the antifouling property of membranes. The result of dynamic fouling experiments indicated that the modified membrane exhibited better antifouling (of which the irreversible fouling degree was 7.1%) compared with commercial membrane BW30 (of which the irreversible fouling degree was 13.5%). © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46931.
Application of the response surface methodology for optimizing the adsorptive removal of chromate using a magnetic crosslinked chitosan nanocomposite
Authors: Zeraatkar Moghaddam Ali , Ghiamati E. , Ayati A. , Ganjali M. R. 
Published: October 2018

ABSTRACTExperimental design was used to optimize the adsorptive removal of chromate using a synthesized crosslinked chitosan with a magnetic NiFe2O4 core. In this regard, the response surface methodology which is based on central composite design, was used to determine the relation between the parameters influencing the adsorption efficiency. The statistical parameters of the resulting model were R2 = 0.9922, and F‐value = 164.48. As a final step, a nonlinear optimization was performed and the respective optimal values for pH, amount of the adsorbent, initial concentration of the pollutant, and contact time were determined as 4, 0.8 g L−1, 150 ppm, and 25 min, and the predicted removal efficiency at a 95% confidence level was determined as 100.8 ± 1.8%, which was in good agreement with the experimental value (i.e., 95.5 ± 5.7%). © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47077.
Enhanced high‐temperature dielectric and microwave absorption properties of SiC fiber‐reinforced oxide matrix composites
Authors: Gao Hui , Luo Fa , Wen Qinlong , Jia Hongyao , Zhou Wancheng , Zhu Dongmei 
Published: October 2018

ABSTRACTBecause of outstanding performances of the SiC fiber‐reinforced ceramic matrix composites in aircraft/aerospace systems, two silicon carbide fiber‐reinforced oxide matrices (SiCf/oxides) composites have been prepared by a precursor infiltration and sintering method. Results indicate that the flexural strength of the SiCf/Al2O3–SiO2 composite reaches 159 MPa, whereas that of the SiCf/Al2O3 composite is only 50 MPa. The high‐temperature microwave absorption properties of the composite are significantly enhanced due to choosing Al2O3 and SiO2 as the hybrid matrices. Particularly, the minimum reflection loss (RL) value of the SiCf/Al2O3–SiO2 composite reaches −37 dB in the temperature of 200 °C at 8.6 GHz, and the effective absorption bandwidth (RL ≤ −5 dB) is 4.2 GHz (8.2–12.4 GHz) below 400 °C. The superior microwave absorption properties at high temperatures indicate that the SiCf/Al2O3–SiO2 composite has promising applications in civil and military areas. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47097.
Construction of continuous proton‐conduction channels through polyvinylimidazole nanotubes to enhance proton conductivity of polymer electrolyte membrane
Authors: Hou Jinghe , Sun Xiang , Gu Xinxin , Liu Shanshan , Xiao Zhenyu , Liu Gang , Ding Huili 
Published: October 2018

ABSTRACTProton‐exchange membranes (PEMs) with high proton conductivity and low cost are crucial for the commercial promotion of proton‐exchange membrane fuel cells. In this study, inspired by the mechanism of plant ducts transporting moisture and biological proton transfer, polyvinylimidazole nanotubes (PVINTs) are prepared by a simple template method and then incorporated into a sulfonated poly(aryl ether sulfone) (SPES) matrix to fabricate composite membranes (SPES/PVINTs‐X, where X is PVINT content in percent). The membranes were fully characterized using field emission scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and mechanical testing. The results indicated that the incorporation of PVINTs could improve the mechanical performance and dimensional stability of the membranes. In particular, the SPES/PVINTs‐7.5 composite membrane achieves remarkable results of proton conductivity of 0.212 S/cm under fully hydrated conditions at 80 °C, which is 56% higher than that of the SPES membrane. The construction of proton‐transfer channels through polymer nanotubes described in this paper may provide new insights into the preparation of composite proton‐exchange membranes. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47106.
Polyester‐based phase change materials with flexible poly(ethylene glycol) chains for thermal energy storage
Authors: Wu Bo , Liu Zhimeng , Xiao Yao , Wang Yi , Zhou Changlin , Zhang Xi , Lei Jingxin 
Published: October 2018

ABSTRACTPhase change materials are capable of storing renewable energy in an economical, feasible, and green way. Here, novel polyester‐based solid–solid phase change materials (PPCMs) are synthesized through solvent‐free crosslinking polymerization. Poly(ethylene glycol) (PEG) is used as the phase change ingredient, while crosslinked polyester acts as the supporting material. One chain end of PEG reliably bonds with the rigid skeleton, while another chain end is movable. The combination of reliable crosslinked structures with flexible PEG chains endows the PPCMs with good thermal storage capacity and outstanding thermal reliability simultaneously. Fourier transform infrared spectroscopy is adopted to confirm the chemical structures of PPCMs. Their excellent crystalline properties are confirmed by wide‐angle X‐ray diffraction and polarizing optical microscopy (POM). Phase change properties are investigated using differential scanning calorimetry (DSC) and POM images. It is obvious in the DSC results that PPCMs have good thermal storage capacity in the range 18–63 °C with phase change enthalpy reaching 139.0 J/g. POM images vividly reveal the crystallization process of PPCMs. Additionally, thermal stability is studied using thermogravimetric analysis, and the results show that PPCMs are thermally stable up to 300 °C. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47108.
Systematic investigation of mechanical properties and fracture toughness of epoxy networks: Role of the polyetheramine structural parameters
Authors: Abdollahi H. , Salimi A. , Barikani M. , Samadi A. , Hosseini Rad S. , Zanjanijam A. R. 
Published: October 2018

ABSTRACTPolyetheramine (PEA)‐modified epoxies with various types of PEAs were prepared and respective effects on characteristics of epoxy networks were studied. The used PEAs were polyethylene glycol diamine (PEG‐amine) and polypropylene glycol diamine (PPG‐amine) with two different molecular weights (i.e., 200 and 400 g mol−1). According to mechanical tests, the structural parameters of PEAs played an important role in final properties of epoxy/amine systems. PEG400‐amine and PPG200‐amine had the highest and lowest effects on the properties of epoxy networks, respectively. Whereas 10 phr PEG400‐amine increased critical stress intensity factor (KIC) and critical strain energy release rate (GIC) of the epoxy up to 82 and 294%, the same number of PPG200‐amine chains caused to increase the KIC and GIC up to 11 and 34%. This discrepancy could be assigned to higher flexibility index (φ = 26.22), longer chain length (~27 atoms), and higher secondary interactions [δ = 9.69 (cal cm−3)0.5] of PEG400‐amine in comparison with PPG200‐amine [with φ = 8.08, ~10 atoms in chain, and δ = 8.98 (cal cm−3)0.5]. Shear yielding as a toughening mechanism was proposed based on microscopy of the crack tips. These in‐depth studies could uncover underlying structure–property relationships in a relevant class of PEA‐like modifiers, shedding light on the future design of top‐performing homogeneous tough polymer networks. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47121.
Hemocompatibility of 2‐N‐3,6‐O‐sulfated chitosan films
Authors: Moraes A. F. , Moreira Filho R. N. F. , Passos C. C. O. , Cunha A. P. , Silva L. M. A e , Freitas L. B. N. , Vasconcelos N. F. , Ricardo N. M. P. S. , Canuto K. M. , Rosa M. F. , Leal L. K. A. M. , Vieira R. S. 
Published: October 2018

ABSTRACTSulfated chitosan (SC) can be used for such coating because of its similarity with heparin. The position of sulfate group incorporation in the chitosan chain is important for the improvement of its biological mechanism. The substitution of each reactive group of chitosan is required to increase the electrostatic repulsion between the sulfated films and blood proteins or platelets, and, thereby, reduce the thrombus formation. Moreover, the polymeric hydroxyl groups can activate the complement system through the alternative pathway. In this study, we developed SC films, with larger distribution of sulfate groups by substitution of three reactive groups in the chitosan chain to improve its hemocompatibility. Successful chemical modification confirmed the partially 2‐N‐3,6‐O‐SC. The hemocompatibility results showed decrease in bovine serum albumin and fibrinogen adsorption, platelet adhesion and an increase in the intrinsic pathway anticoagulant activity. Based on these results, partially tri‐SC can be considered suitable candidate for coating blood‐contacting medical devices. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47128.
Preparation of breathable polyurethane membranes with quaternary ammonium salt diols providing durable antibacterial property
Authors: Aydin Ahmet , Demirci Fatma , Orhan Mehmet , Kocer Hasan B. 
Published: October 2018

ABSTRACTAim of this study was to produce hydrophilic breathable polyurethane membranes providing antibacterial property permanently by incorporation of a quaternary ammonium salt diol (QAS). The study was carried out by synthesis of nine different polyurethanes by solution polymerization through variations of their QAS and isocyanate contents. Fully amorphous membranes at a thickness of ~30 μm were produced from the synthesized polymers and their thermal and morphological characteristics were determined. The effect of morphological structures on the membrane water vapor transmission rates (WVTR) and antibacterial properties were correlated. The WVTR increased with the increased temperature in all membranes over 10–40 °C, all produced membranes showed water resistance up to a pressure of 2100 cmH2O and WVTR values above 60 g/m2 h at 30 °C. The WVTR increased by increasing amount of QAS including cationic groups and decreased by increasing isocyanate amount reducing the molecular chain flexibility. In addition, while the unmodified membranes did not show any antibacterial activity, the QAS‐added membranes provided significant inactivation against Staphylococcus aureus and Escherichia coli of about 104 CFU within 5 h of contact time. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47133.
Epoxidized castor oil‐based diglycidyl‐phthalate plasticizer: Synthesis and thermal stabilizing effects on poly(vinyl chloride)
Authors: Chen Jie , Liu Zengshe , Wang Kui , Huang Jinrui , Li Ke , Nie Xiaoan , Jiang Jianchun 
Published: October 2018

ABSTRACTEpoxidized castor oil‐based diglycidyl‐phthalate (ECODP) was synthesized and incorporated into poly(vinyl chloride) (PVC) for the first time. The chemical structure of the ECODP was confirmed. The plasticizing effects of ECODP as a replacement for commercial plasticizer dioctyl phthalate (DOP) were investigated. The thermal stability and mechanical properties of PVC films before and after aging were investigated using thermogravimetric analysis (TGA), TGA‐FTIR analysis, dynamic mechanical analysis (DMA), and tensile tests. The results indicated that PVC films plasticized with ECODP significantly improved thermal stability, compatibility, and flexibility. When DOP was substituted with ECODP completely, the initial decomposition temperature, 5, 10, 50, and 70% mass loss temperatures (Ti,T5,T10,T50, andT70) increased by 24.7, 38.9, 32.0, 30.3, and 102.7 °C, respectively. The functional mechanism of the ECODP as a thermal stabilizing plasticizer and the plasticization mechanism of PVC composites were also investigated. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47142.
Hydrophobic, amorphous metal–organic network readily prepared by complexing the aluminum ion with a siloxane spaced dicarboxylic acid in aqueous medium
Authors: Cazacu M. , Turcan‐Trofin G.‐O. , Vlad A. , Bele A. , Shova S. , Nicolescu A. , Bargan A. 
Published: October 2018

ABSTRACTA less common dicarboxylic acid with siloxane spacer, 1,3‐bis(carboxypropyl)tetramethyldisiloxane, whose structure is for the first time determined crystallographically, is used to coordinate aluminum through an environment‐friendly preparation process, resulting in a polymeric structure of amorphous metal–organic framework (aMOF) type. The high flexibility of the spacer induced by the siloxane bond gives the polymeric product a glass transition slightly below room temperature, while the long length of the former creates the premises for collapse of the network and consequently reduced porosity. At the same time, the high hydrophobicity of the tetramethyldisiloxane fragment and its low surface energy, which causes it to migrate to the air interface, gives the network low moisture sorption capacity guaranteeing the stability of its properties in a wet environment. The particulate complex, of the order of 1–200 nm, as generated by the synthesis, proves to be suitable as filler for silicone with outstanding reinforcement effect, without significantly affecting their transparency. The presence of the dimethylsiloxane units in the structure of both the matrix and the filler ensures good incorporation of the latter without the need for special compatibility treatments. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47144.
Viscoelastic and acoustic characterization of polyurethane‐based acoustic absorber panels for underwater applications
Authors: Jayakumari V. G. , Shamsudeen R. K. , Rajeswari R. , Mukundan T. 
Published: October 2018

ABSTRACTAcoustic absorbers that can have applications in a desired frequency band are a challenge often encountered in underwater acoustic absorber panel design. Polyurethane‐based sound absorbing composite panels were designed with the help of finite element method (FEM) modeling using COMSOL for material formulations that can give optimum performance of echo reduction (ER) with minimum thickness. Polyurethanes of different compositions were evaluated for their acoustic performance using FEM modeling and experimental validation of the modeling results was done. The frequency‐dependent modulus and damping properties were generated using dynamic mechanical analyzer and time–temperature superposition were performed to generate the material properties in the high frequency range (up to 25 kHz), which are significant for underwater acoustic detection applications and these data were used as inputs for modeling studies. Acoustic properties of the samples were experimentally evaluated using a water‐filled pulse tube in 2–15 kHz frequency range as well as in an acoustic tank test facility for bigger dimension panels. These are nonresonant type absorbers capable to overcome limitations arising from environmental factors such as high hydrostatic pressures and also they are effective over a broad range of frequency (500 Hz–15 kHz) with ER > 15 dB. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47165.