bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morning versus Nocturnal Heart Rate and Heart Rate Variability Responses to Intensified Training in Recreational Runners
Authors: Nuuttila Olli-Pekka , Kyröläinen Heikki , Kokkonen Veli-Pekka , Uusitalo Arja 
Published: November 2024

Abstract
Background
Resting heart rate (HR) and HR variability (HRV) are widely used parameters to assess cardiac autonomic nervous system function noninvasively. While resting assessments can be performed during sleep or after awakening, it would be relevant to know how interchangeable the results of these measurements are. This study aimed at examining the alignment between nocturnal and morning assessments during regular endurance training and in response to intensive training. A total of 24 recreational runners performed a 3-week baseline period (BL) and a 2-week overload (OL) period (Lucia’s training impulse + 80%). Their running performance was assessed with a 3000-m running test after the BL and OL. The participants recorded daily their nocturnal HR and HRV (the natural logarithm of the root mean square of successive differences; LnRMSSD) with a photoplethysmography-based wrist device and performed an orthostatic test (2-min supine, 2-min standing) every morning with a chest-strap HR sensor. The HR and LnRMSSD segments that were analyzed from the nocturnal recordings included start value (SleepStart), end value (SleepEnd), first 4-h segment 30 min after detected sleep onset (Sleep4h), and full sleep time (SleepFull). The morning segments consisted of the last-minute average in both body positions. All segments were compared at BL and in response to the 3000-m test and OL.

Results
All nocturnal HR and LnRMSSD segments correlated with supine and standing segments at BL (r = 0.42 to 0.91, p < 0.05). After the 3000-m test, the HR increased and LnRMSSD decreased only in the SleepStart, Sleep4h, and SleepFull segments (p < 0.05). In response to the OL, the standing HR decreased (p < 0.01), while the LnRMSSD increased (p < 0.05) in all segments except for SleepStart. The Pearson correlations between relative changes in nocturnal and morning segments were − 0.11 to 0.72 (3000-m) and − 0.25 to 0.79 (OL). The OL response in Sleep4h HR and LnRMSSD correlated with the relative change in 3000-m time (r = 0.63, p = 0.001 and r=-0.50, p = 0.013, respectively).

Conclusions
Nocturnal and morning HR and LnRMSSD correlated moderately or highly in the majority of cases during the BL, but their responses to intensive training were not similarly aligned, especially in LnRMSSD. The nocturnal segments seemed to be sensitive to physical loading, and their responses were associated with the performance-related training responses.
Australian private healthcare staff perspectives on patient reported experience measures (PREMs): a qualitative interview study
Authors: Verlis Krista , McCaffery Kirsten , Copp Tessa , Dodd Rachael , Nickel Brooke , Laidsaar-Powell Rebekah 
Published: November 2024

Abstract
Objective
Patient reported experience measures (PREMs) are common tools utilised in hospitals to support quality improvements, allow consumers to provide feedback on care experiences and can be used to support consumers’ hospital selections. This study aimed to understand the views and opinions of private hospital staff on PREM use and the utility of PREMs as a consumer decision-making tool.

Method
Qualitative, semi-structured interview study conducted via telephone between March-June 2023. Participants (n = 10) were recruited from major private healthcare providers in Australia with half representing hospital-based staff and the other half corporate head office staff who work in patient experience and quality. Interviews were audio-recorded, transcribed, and analysed thematically.

Results
PREM benefits included an understanding of patient experience that improved provision of patient centred care with feedback acting as catalyst for change, to corporate-level strategic initiatives that address specific issues. Drawbacks of PREM reporting included concerns around skewed results by biased respondents, and completion based on hard to alter items (e.g., infrastructure) or on matters outside of hospital control (e.g., insurance). Staff had mixed reactions to consumers using PREMs results when selecting a hospital, some advocated for transparency while others feared consumers would misinterpret the data.

Conclusions
Improved real-time reporting of PREMs, learning from other industries about recording customer experience, and mandatory reporting by private hospitals could further the benefits of PREM measurement in private healthcare. Recognised was the need for PREMs to be displayed in a readily understood way so those with limited health literacy can correctly interpret.
Masson tumor of the right atrial appendage presenting as cardiac tamponade: a case report
Authors: Kanj Mouhammad , Naderi Samah , Khalil Majed , El Khoury Nabil , Mansour Ziad , Chami Rock 
Published: November 2024

Abstract
Background
Intravascular papillary endothelial hyperplasia (Masson tumor) is a rare, benign vascular tumor characterized by the proliferation of endothelial cells within blood vessels. While it typically affects the skin and subcutaneous tissues, it can occasionally appear in unusual locations.

Case presentation
We report a rare case of Masson tumor located in the right atrial appendage of a healthy individual. This case was complicated by atrial wall rupture and subsequent cardiac tamponade. The tumor was successfully resected under cardiopulmonary bypass.

Conclusion
This case highlights a rare occurrence of Masson tumor in the heart, emphasizing the importance of prompt surgical intervention to prevent life-threatening complications such as cardiac tamponade.
Percutaneous radiofrequency ablation for stage B1 of modified Bolondi’s subclassification for intermediate-stage hepatocellular carcinoma
Authors: Eid Ragaey Ahmad , Abdel Fattah Ali M. , Haseeb Alaa Farouk , Hamed Ahmed Moheyeldien , Shaker Marwa Abdallah 
Published: November 2024

Abstract
Background
Hepatocellular carcinoma is considered the most common cause of hepatic focal lesions in Egypt. TACE is still the recommended treatment approach for patients in the intermediate stage. In the current research, we evaluated the safety and efficacy of percutaneous radiofrequency ablation (RFA) for a selected category in the intermediate stage (BCLC stage B).

Methods
This prospective study was conducted in the Department of Gastroenterology, Hepatology, Faculty of Medicine, Beni-Suef University between September 2022, and March 2024. In addition to AFP, Pelviabdominal ultrasound and computerized tomography (CT) were used for HCC diagnosis. According to the Child–Pugh score plus Milan and up-to-7 criteria, we used Modified Bolondi’s Subclassification (Kinki Criteria), to sub-classifies the BCLC B stage into B1/B2/B3 subcategories. Radiofrequency ablation was done in the interventional ultrasound unit. Treatment efficacy was assessed 6 months after tumor ablation.

Results
One hundred twenty participants were enrolled in our research trial, 72 (60%) were within the intermediate stage, and 48 (40%) had early-stage HCC. Most of our patients were males, 78 (65%). All the early-stage-HCC patients were Child–Pugh Score A (n = 48), while the intermediate-stage (BCLC B) group was classified in both Child–Pugh Score A (n = 59) and B (n = 16). Within the intermediate group (BCLC-stage B), All enrolled cases fell within category “B1” within the Kinki Criteria. Logistic regression analysis illustrated that the pre-treatment level of Platelet count and post-treatment level of AFP shows a statistically significant prediction effect on treatment response rate with p-value (0.028 and 0.007 respectively).

Conclusion
percutaneous radiofrequency ablation is considered an effective treatment option for the B1 subcategory according to Kinki Criteria for intermediate-stage HCC (BCLC-B1) but long-term follow-up is recommended.
Innovative Glucagon-based Therapies for Obesity
Authors: Enyew Belay Kibret , Jemal Rebil Heiru , Tuyizere Aloys 
Published: November 2024

Abstract
Obesity poses a significant global health challenge, with an alarming rise in prevalence rates. Traditional interventions, including lifestyle modifications, often fall short of achieving sustainable weight loss, ultimately leading to surgical interventions, which carry a significant burden and side effects. This necessitates the exploration of effective and relatively tolerable pharmacological alternatives. Among emerging therapeutic avenues, glucagon-based treatments have garnered attention for their potential to modulate metabolic pathways and regulate appetite. This paper discusses current research on the physiological mechanisms underlying obesity and the role of glucagon in energy homeostasis. Glucagon, traditionally recognized for its glycemic control functions, has emerged as a promising target for obesity management due to its multifaceted effects on metabolism, appetite regulation, and energy expenditure. This review focuses on the pharmacological landscape, encompassing single and dual agonist therapies targeting glucagon receptors (GcgRs), glucagon-like peptide-1 receptors (GLP-1Rs), glucose-dependent insulinotropic polypeptide receptors (GIPRs), amylin, triiodothyronine, fibroblast growth factor 21, and peptide tyrosine tyrosine. Moreover, novel triple-agonist therapies that simultaneously target GLP-1R, GIPR, and GcgR show promise in augmenting further metabolic benefits. This review paper tries to summarize key findings from preclinical and clinical studies, elucidating the mechanisms of action, safety profiles, and therapeutic potential of glucagon-based therapies in combating obesity and its comorbidities. Additionally, it explores ongoing research endeavors, including phase III trials, aimed at further validating the efficacy and safety of these innovative treatment modalities.
A Sociocognitive Grading Model for First-Year Writing Classes
Authors: Nastal Jessica 
Published: November 2024

Abstract
This article offers a theory of action model for grading in first-year writing classes, as enacted at two public, suburban, Midwestern two-year colleges. First, it analyzes labor-based contract grading and specifications grading through this model, examining how these popular grading methods have manifested in unintended negative consequences for historically and multiply marginalized students. Then, it proposes a sociocognitive grading model designed to maximize course-level success rates for New Majority college students. The sociocognitive model was iteratively built on feminist standpoint theory, intersectional learning sciences, multilingual writing pedagogy, and disability studies. Thus far, student course-level success has improved, along with their learning in four domains of a robust writing construct: intrapersonal, interpersonal, cognitive, and health. While it does not prescribe specific patterns of response, this model nevertheless establishes an overall referential frame that holds the potential to incorporate empirically based best response practices.
Exercise-Based Telerehabilitation for Heart Failure Patients Declining Outpatient Rehabilitation—A Randomized Controlled Trial
Authors: LUNDGREN KARI MARGRETHE , LANGLO KNUT ASBJØRN RISE , SALVESEN ØYVIND , ASPVIK NILS PETTER , MO RUNE , ELLINGSEN ØYVIND , VESTERBEKKMO ELISABETH , ZANABONI PAOLO , DALEN HÅVARD , AKSETØY INGER-LISE AAMOT 
Published: November 2024

ABSTRACT

Purpose
Cardiac rehabilitation participation rates are low despite strong recommendations, and many chronic heart failure patients remain physically inactive. Rural living, long travel distance, costs, age, and frailty might be factors explaining this. To increase cardiac rehabilitation uptake, we designed an exercise-based randomized controlled telerehabilitation trial enabling chronic heart failure patients unable or unwilling to participate in outpatient cardiac rehabilitation to exercise at home. Aim was to evaluate the long-term effects of telerehabilitation on physical activity levels.

Methods and results
Chronic heart failure patients (n = 61) with reduced (≤40%), mildly reduced (41%–49%), or preserved ejection fraction (≥50%) were randomized (1:1) to telerehabilitation (n = 31) with an initial 3-month group-based high-intensity exercise telerehabilitation program or control (n = 30), with regular follow-up visits over a 2-yr period. All participants attended a “Living with heart failure” course. Outcomes were measures of physical activity, peak oxygen uptake, 6-min walk test distance, quality of life, morbidity, and mortality. We found no significant differences between groups for long-term changes in moderate to vigorous activity (MVPA) or peak oxygen uptake from baseline to the 2-yr follow-up. Nor quality of life differed between groups, but both groups had significant within-group improvements in score on the Minnesota Living with Heart Failure Questionnaire (P = 0.000) and improvement in EQ-5D visual analog scale score was significant (P = 0.05) in the telerehabilitation group.

Conclusions
Telerehabilitation performed as home-based real-time high-intensity exercise sessions provided by videoconferencing for participants unable or unwilling to participate in standard outpatient cardiac rehabilitation did not affect long-term physical activity levels or physical capacity as expected. Still, a positive effect on health-related quality of life was seen in both groups.
Investigations of the vascular endothelial factor levels’ changes in experimental diabetic retinopathy
Authors: Preys Nataliya , Savytskyi Ivan 
Published: November 2024

Introduction: The paper presents the results of the vascular endothelial growth factor of rats with experimental diabetic retinopathy (DR).
Material and methods: Experimental studies were performed on white Wistar rats, which were divided into 7 groups: 1st group – intact animals; 2nd group – 60 animals with modelling of DR without correction (control pathology); 3rd group –60 animals with modelling of DR with correction of hyperglycemia; 4th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept and L-arginine solution; 5th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept and bromfenak; 6th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept, L-carnitine solution and bromfenak; 7th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept, L-arginine solution and citicoline.
Results: The results of the analysis of the VEGF in the 2nd group confirm the development of DR, a particularly pronounced increase in the marker was detected on the 180th day of the development of the pathological process. The results of the 4th group indicate that the involvement of a nitric oxide donor and aflibercept in the correction of DR has positive effect on the reduction of the VEGF level, more pronounced compared to the 3rd group, but it does not reach normative values. It is observed that the correction of the simulated pathological condition by reducing hyperglycemia, administration of aflibercept and bromfenac (group No. 5) gives positive results, but less pronounced, compared to the data of the 4th group. It was found that in rats with DR with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac (group No. 6) at the first stage, there is a pronounced effectiveness of the proposed method of correction in comparison with the previously considered methods. The most pronounced positive effect of normalizing the VEGF level is observed when using a hypoglycemic drug in combination with the administration of aflibercept, a solution of L-arginine and citicoline (group No. 7).
Conclusions: The obtained data confirm the development of diabetic retinopathy, a particularly marked increase in the marker was detected on the 180th day of the development of the pathological process (p<0.001). Aflibercept has a positive effect on the normalization of this condition, but a more pronounced effect is observed in combination with long-term administration of L-arginine. The relationship between the normalization of the vascular growth factor and the correction of hypoxia was also revealed.
On the Impossibility of Convergence of Mixed Strategies with Optimal No-Regret Learning
Authors: Muthukumar Vidya , Phade Soham , Sahai Anant 
Published: November 2024

We study the limiting behavior of the mixed strategies that result from optimal no-regret learning in a repeated game setting where the stage game is any 2 × 2 competitive game. We consider optimal no-regret algorithms that are mean-based and monotonic in their argument. We show that for any such algorithm, the limiting mixed strategies of the players cannot converge almost surely to any Nash equilibrium. This negative result is also shown to hold under a broad relaxation of these assumptions, including popular variants of Follow-the-Regularized Leader with optimism or adaptive step sizes. Finally, we provide partial evidence that the monotonicity and mean-based assumptions can be removed or relaxed. Our results identify the inherent stochasticity in players’ realizations as a critical factor underlying this divergence, and demonstrate a crucial difference in outcomes between using the opponent’s mixtures and realizations to make updates. Funding: V. Muthukumar was supported by a Simons-Berkeley Research Fellowship, NSF awards IIS-2212182 and CCF-2239151, and generous gifts from Amazon, Adobe, and Google. S. Phade acknowledges the support of the NSF [Grants CNS-1527846 and CCF-1618145] and the NSF Science & Technology Center [Grant CCF-0939370 (Science of Information)]. A. Sahai acknowledges the support of the ML4Wireless center member companies and the NSF [Grants AST-144078 and ECCS-1343398].
Long-term follow-up of ceramic-on-metal total hip arthroplasty
Authors: Baker Gavin , Hill Janet , O'Neill Francis , McChesney Jane , Stevenson Michael , Beverland David 
Published: November 2024

AimsIn 2015, we published the results of our ceramic-on-metal (CoM) total hip arthroplasties (THAs) performed between October 2007 and July 2009 with a mean follow-up of 34 months (23 to 45) and a revision rate of 3.1%. The aim of this paper is to present the longer-term outcomes.MethodsA total of 264 patients were reviewed at a mean of 5.8 years (4.6 to 7.2) and 10.1 years (9.2 to 10.6) to determine revision rate, pain, outcome scores, radiological analysis, and blood ion levels. Those who were unwilling or unable to travel were contacted by telephone.ResultsThe all-cause revision rate at six years was 3.1% (eight THAs), increasing to 8.8% (18 THAs) at ten years. Of these, there were four and then seven bearing-related revisions at six and ten years, respectively. There was a statistically significant deterioration in the visual analogue scale pain score and Oxford Hip Score (OHS) between six and ten years. There were 18 CoM THAs in 17 patients who had a cobalt or chromium level over 4 ppb and ten CoM THAs in nine patients who had a cobalt or chromium level higher than 7 ppb with a statistically significant increase in chromium levels only between the two timepoints. Overall, 84 stems (39.1%) had significant radiolucent lines at ten years compared to 65 (25.5%) at six years.ConclusionWhen compared to the original review, there has been a significant deterioration in pain score, OHS, radiograph appearance, and, most critically, survival has fallen to 91.2%, which does not meet the Orthopaedic Data Evaluation Panel (ODEP) 10 A* 95% threshold. Although this bearing is no longer on the market, 2.5% were bearing-related revisions, which have relevance to the discussion around modular dual-mobility implants that have a similar metal interface.
Day-case success or why still in hospital after total hip, total knee, and medial unicompartmental knee arthroplasties?
Authors: Danielsen Oddrún , Jensen Christian B. , Varnum Claus , Jakobsen Thomas , Andersen Mikkel R. , Bieder Manuel J. , Overgaard Søren , Jørgensen Christoffer C. , Kehlet Henrik , Gromov Kirill , Lindberg-Larsen Martin 
Published: November 2024

AimsDay-case success rates after primary total hip arthroplasty (THA), total knee arthroplasty (TKA), and medial unicompartmental knee arthroplasty (mUKA) may vary, and detailed data are needed on causes of not being discharged. The aim of this study was to analyze the association between surgical procedure type and successful day-case surgery, and to analyze causes of not being discharged on the day of surgery when eligible and scheduled for day-case THA, TKA, and mUKA.MethodsA multicentre, prospective consecutive cohort study was carried out from September 2022 to August 2023. Patients were screened for day-case eligibility using well defined inclusion and exclusion criteria, and discharged when fulfilling predetermined discharge criteria. Day-case eligible patients were scheduled for surgery with intended start of surgery before 1.00 pm.ResultsOf 6,142 primary hip and knee arthroplasties, eligibility rates for day-case surgery were 34% for THA (95% CI 32% to 36%), 34% for TKA (95% CI 32% to 36%), and 52% for mUKA (95% CI 49% to 55%). Surgery before 1.00 pm was achieved in 85% of eligible patients. The day-case success rate among patients with surgery before 1.00 pm was 59% (95% CI 55% to 62%) for THA, 61% (95% CI 57% to 65%) for TKA, and 72% (95% CI 68% to 76%) for mUKA. Overall day-case success rates (eligible and non-eligible) were 19% (95% CI 17% to 20%) for THA, 20% (95% CI 18% to 21%) for TKA, and 42% (95% CI 39% to 45%) for mUKA. Adjusted analysis confirmed higher day-case success in eligible mUKA patients (odds ratio 1.9 (1.6 to 2.3)) compared to TKA and THA patients. Primary causes for day-case failure were mobilization issues (9% to 12% between procedures), prolonged spinal anaesthesia (4% to 9%), and postoperative nausea and vomiting (PONV) (4% to 14%).ConclusionTHA and TKA patients showed comparable eligibility (34%) with similar day-case success rates (59 to 61%), whereas mUKA patients demonstrated higher eligibility (52%) and day-case success (72%). Mobilization issues, prolonged spinal anaesthesia, and PONV were the most frequent causes for not being discharged.
Psychological experience of patients with postpartum depression: A qualitative meta-synthesis
Authors: Jiaming Wu , Xin Guo , Jiajia Du , Junjie Peng , Xue Hu , Yunchuan Li , Yuanfang Wu 
Published: November 2024

Purpose
To determine the psychological experiences of patients with postpartum depression by systematically reviewing, retrieving, and synthesizing data from qualitative studies.

Methods
Nine databases were systematically searched for relevant publications, from database establishment to September 20, 2024. All qualitative studies in English and Chinese that explored the real-life experiences, feelings, etc., of individuals affected by postpartum depression after childbirth were included. The qualitative meta-synthesis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Two independent reviewers selected these studies and evaluated the quality of each study, conducting a meta-analysis to integrate the results.

Results
A total of 28 studies revealed 12 sub-themes and 3 descriptive themes: negative physical and psychological experiences and coping strategies, role transition discomfort and impact, lack of relevant support.

Conclusion
The prominence of negative physical and psychological experiences, the discomfort of role transformation, and the lack of relevant support in patients with postpartum depression. In future studies, more attention should be paid to maternal mental health, and full mental health screening during pregnancy and childbirth should be implemented. Psychological counseling services should also be provided to pregnant women. [REGISTRATION: PROSPERO ID: CRD42024504506].