bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coaction of Electrostatic and Hydrophobic Interactions: Dynamic Structural Constraints on Disordered TrkA Juxtamembrane Domain
Authors: Wang Zichen , Fan Huaxun , Hu Xiao , Khamo John , Diao Jiajie , Zhang Kai , Pogorelov Taras 
Published: September 2019

Effective transmembrane signaling is vital to the life of the cell. However, plasma membrane dynamics pose numerous challenges for signaling proteins and attempts to study them. The receptor tyrosine kinase family transmits signals via a single transmembrane helix and a flexible juxtamembrane domain (JMD). Detailedstudies of JMD-membrane interactions are challenging due to naturally slow lipid diffusion. We employ a combination of all-atom molecular dynamics of highly mobile membrane mimetics with in vitro and in cell experiments to capture critical roles of electrostatic and hydrophobic membrane-JMD interactions oftropomyosin receptor kinase A (TrkA). We show that a conserved three-residue hydrophobic patch enables JMD anchoring in the membrane, a single residue deletion can dramatically reverse it, and a single charged to hydrophobic residue mutation can enhance binding affinity. The highly charged anionic lipids are effectiveat promoting binding and restraining JMD flexibility. Our work highlights versatility of molecular controls of these interactions.
External cueing on gait parameters in Parkinson’s Disease
Authors: Deepa S  , Ramana K  
Published: September 2019

Parkinson’s disease which is characterized by paucity of movement, leading to the abnormal gait parameters. The gait pattern is characterized by shuffling as festinant gait. Freezing is an incapacitating motor symptom is also one of the leading causes of gait abnormality leading to falls. Cueing strategy evokes a more goal-directed type of motor control results in improved gait parameters. Aims and Objectives:-The purpose of this study to find the effectiveness of external cueing on the gait parameters as cadence, step length and stride length. Materials and Methodology: - 30 subjects diagnosed as Parkinson’s disease were randomly assigned to three groups, the walking ability was assessed using a 10 meter walk test, and pre test score was recorded. The external cueing technique was applied for a session of 4 days per week for 4 weeks; each session lasted for about 30 minutes, at the end for 4 weeks the post test scores were recorded. Results: - External cueing with a combination of audio- visual showed significant improvement in the gait parameters. Conclusion: - The improvement showed in the pre test to post test reflected the need for introducing the external cueing in improving gait and attention during a motor task.
Determinants of Social Poverty in Mountainous Areas of Talegong, Garut Regency
Authors: Aspiranti Tasya , Amaliah Ima 
Published: September 2019

Poverty is a multidimensional problem since it is not only an economic problem but also a social, political and even cultural problem. The purpose of this research is to identify the determinant factor of social poverty in the mountain region of Talegong Subdistrict. The research type is quantitative descriptive with field survey method. The analysis technique using descriptive statistics and the sample is determined by purposive random sampling. The concept of social poverty uses BPS and Chambers indicators. Respondents interviewed were village heads, LPMDes, community leaders and communities in seven villages in Talegong sub-district. Based on the results of observations and interviews with respondents, there are four determinants of social poverty in Talegong sub-district: the factor of poverty itself, abandonment, alienation & remoteness and vulnerable to natural disasters. While three other factors such as physical, mental and social neglect factors; social impairment factor and behavioral deviation from religious and community norms, and factors of victims and physical, mental and social violence were not found in Talegong sub-district.
Problem of Public Accountability in Village Governance in Rural Enrekang, Indonesia
Authors: Nurlinah Nurlinah , Haryanto Haryanto , Musdah Erwin 
Published: September 2019

This article examines a range of issues in the implementation of village governance to enhance public accountability. Subsequent to village law, a village now has to deal with how to manage government finances by promoting public accountability knowing that public accountability is the spirit of reviving democracy in village government. This study investigates the practice of village fund governance by collecting qualitative data from 9 villages in Enrekang Regency, South Sulawesi. The villages were randomly selected, one village in 9 sub-districts of 12 sub-districts in Enrekang. There were three primary causes of the lack of public accountability, namely: institutional arrangement, social organizations, and local culture. In practice, each cause has a different impact on determining the level of accountability in a village. It implies that the principles of good governance are still not fully embraced by local villagers and village government.
KADAR KLOROFIL DAUN PAKCOY (BRASSICA CHINENSIS L.) SETELAH PERLAKUAN PUPUK KANDANG DAN AMPAS TAHU SEBAGAI BAHAN AJAR MATA KULIAH FISIOLOGI TUMBUHAN
Authors: Wenno Stenly Jacob , Sinay H 
Published: September 2019

Background: Pakcoy (Brassica chinensis L.) is a vegetable plant originating from China that has leaf stalks that are wider and larger than green mustard greens. Pakcoy has nutritional value such as vitamin C, vitamin A, carbohydrates, fiber, protein, calcium, magnesium. Chlorophyll is a green leaf substance found in green parts of plants, especially on leaves. One of the factors that influence the chlorophyll content in pakcoy mustard leaves is the soil condition in this case the nutrient content and nutrients in the soil. One way to meet nutrient and nutrient content in the soil is by using organic fertilizers such as manure and tofu.
Method: This study aims to determine the chlorophyll content of pakcoy leaves (Brassica chinensis L.) after giving manure and tofu dregs. Based on the analysis of chlorophyll content using the UV-VIS spectrophotometer method at wavelengths of 644 nm and 663 nm.
Results: The highest levels of chlorophyll A in pakcoy (Brassica chinensis L.) leaves with PK3AT1 treatment (7 kg manure and 7 kg tofu dregs) of 2.007 mg / L, highest chlorophyll B levels in pakcoy (Brassica chinensis L.) leaves with treatment PK3AT3 (7 kg manure and tofu dregs 3 kg) at 2.674 mg / L, and the highest total chlorophyll content in pakcoy (Brassica chinensis L.) leaves with PK3AT1 treatment (7 kg manure and 7 kg tofu dregs) at 4,558 mg / L.
Conclusion: Chlorophyll A, B and total levels in pakchoy (Brassica chinensis L.) leaves after a combination of manure and tofu dregs have high levels of different corophils.
Effect of Menopause on Periodontium - Is There A Link?
Authors: Dabhi Ruzuta Khushal Bhai , Mathur Aditi , Shetty Neema , Makhijani Barkha , Manohar Balaji , Bali Ashish 
Published: September 2019

Introduction: Menopause is associated with important systemic and oral changes. Many researchers have tried to evaluate the influence of hormonal changes associated with menopause in the periodontium, however results are still contradictory.
Objective: The aim of the present study was to evaluate the effect of menopause on the severity of periodontal destruction.
Methods: In the present study 25 systemically healthy women age ranges from 30 to 65 with generalised chronic periodontitis were included. They were divided into 2 groups based on their menstrual history. Group I (control group) included 8 women with normal menstrual cycle and Group II (test group) included 17 postmenopausal women. Clinical parameters Plaque Index, Gingival Index, periodontal probing pocket depth (PPD) and DMFT Index was recorded. The level of bone present was evaluated radiographically.
Results: There were no significant differences between subjects of both the control and test groups in the percentages of sites for presence of plaque (p > 0.37), gingival index (p > 0.161) and DMFT index (p > 0.099). However deeper pockets (p < 0.001) and reduced bone support (p < 0.00) was observed in Group II as compared to Group I.
Conclusion: The findings of the present study suggest, that postmenopausal women have more severe periodontal destruction as compared to premenopausal women.
Study of Cleft Lip and Palate in Kathmandu Model Hospital, Nepal
Authors: Khatun Sanzida 
Published: September 2019

Introduction: Cleft lip and/or palate is a congenitally persistent space affecting orofacial region. It is generally divided into cleft lip (CL), cleft palate (CP) and cleft lip with cleft palate (CLP). The objective of the study was to evaluate distribution of patterns of orofacial clefts according to sex and laterality; predisposing factors and other congenital anomalies associated with cleft lip and/or palate.
Materials & Method: A cross-sectional descriptive type of study was carried out using in 268 patients having cleft lip and/or palate. Types of clefts, predominance of sex and laterality, familial history, associated anomalies and drug and disease history of mother were recorded.
Result: The results revealed 23.51% CL, 54.85% CLP and 21.64% CP. There were 58.21% males and 41.79% females. Positive family history of cleft was present in 28.0% and associated anomalies were observed in 3.7% of the cleft subjects. Mothers of 6.0% of the total patients were exposed to teratogenic agents during first trimester of pregnancy.
Conclusion: It was concluded that among the three types of cleft (CL, CP and CLP), CLP is the most common type. The males are affected more with cleft lip and/or palate than the females. Clefts also have risks of associated congenital anomalies. Exposure to teratogenic agents in first trimester of pregnancy is also associated with orofacial cleft.
Cephalometric Approach to Vertical Facial Height
Authors: Maskey Suvit , Shrestha Rosha 
Published: September 2019

Introduction: The vertical heights and the proportions are very important for balance of the face and attractiveness along with the good smile. Harmonious vertical proportions and the Antero-posterior relations contribute to aesthetics. Therefore it is necessary to determine the vertical facial height and the ratios in treatment planning of the patients. The aims and objectives of this study are to compare the vertical facial heights of patients considering the Lower Anterior Facial Height (LAFH), the Upper Anterior Facial Height (UAFH), Total Anterior Facial Height (TAFH) and Posterior Facial Height (PFH) among the sexes in Class I skeletal group obtained from cephalometric analysis.
Materials & Method: The study material comprised of 52 patients (24 males and 28 females) and lateral cephalometric radiographs were traced with Skeletal Class I relationship. Cephalometric analysis was performed by using hand tracing. Independent t tests were used for comparisons.
Result: The total anterior facial height (TAFH), lower anterior facial height (LAFH), upper anterior facial height (UAFH), total posterior facial height (TPFH) measurements showed no significant differences between both sexes in Skeletal Class I group but statistically significant difference in ratios of posterior facial height and total anterior facial height and also there was statistically significant differences in the ratio between upper facial height and the total anterior facial height (p value <0.05).
Conclusion: This cephalometric analysis can be applied to determine the vertical height of occlusion which can be helpful in prosthetic rehabilitation of edentulous patients.
ONTOLOGY SEBAGAI SOLUSI PENCARIAN MAKNA AMBIGU DALAM DALAM SISTEM YANG HETEROGEN
Authors: Jayadianti Herlina , Nugroho Lukito Edi , Sanntosa Paulus Insap , Widayat Wahyu , Pinto Carlos Sousa 
Published: September 2019

Human beings as creatures of God has tremendous advantages in terms of process knowledge . Knowledge , ideas , predictions , and beliefs intertwined managed to produce a greater range of knowledge in the human brain . With its experience a human can easily distinguish them said the same but have different meanings , or otherwise different words but the same meaning . Of all the advantages it has, on one hand, humans also have various limitations in managing large amounts of data , the limitations of doing a quick search , to the limitations in considering complex data . This is the basis of this study . The research in this paper will focus on an ambiguous word search prototype system , where the system is expected later to understand user queries performed more easily . SPARQL , RDF and ontology is the technology that will be used to support the course of this study .
Pertimbangan Pembelian Oleh-oleh Pada Rute Perjalananan Wisatawan Menggunakan Technique for Others Preference by Similarity to Ideal Solution (TOPSIS)
Authors: Simanjuntak Oliver Samuel , Santosa Budi , Prasetyo Muhammad Bagus 
Published: September 2019

Era modernisasi membawa dampak terhadap kebutuhan masyarakat, yaitu kebutuhan masyarakat melaksanakan pekerjaannya secara cepat dan mudah. Pada khususnya wisatawan, wisatawan yang mengunjungi suatu wilayah berkeinginan cepat dan mudah dalam pencarian oleh-oleh. Dalam pencarian oleh-oleh, wisatawan mengalami kendala dalam penentuan lokasi toko dan oleh-oleh Wisatawan harus mencari toko oleh-oleh secara manual. Aplikasi mobile merupakan salah satu solusi dalam pencarian informasi yang sering digunakan, karena aplikasi mobile dapat berguna dimanapun berada dan kapanpun waktunya. Tersedianya aplikasi mobile juga sering dimanfaatkan masyarakat untuk mencari lokasi suatu tempat atau tujuan menggunakan Maps. Selain itu seiring dengan perkembangan teknologi, sekarang aplikasi mobile juga di manfaatkan dalam proses jual-beli secara online. Hal ini memberikan kemudahan bagi masyarakat dalam membantu, serta menyelesaikan pekerjaannya secara tepat, dan praktis. Aplikasi berbasis Android ini dibangun menggunakan bahasa pemprograman java dengan memanfaatkan metode TOPSIS (Technique For Others Preference by Similarity to Ideal Solution) untuk memberikan pertimbangan kepada pengguna, serta memanfaatkan GoogleMaps API. Dengan aplikasi ini para wisatawan dapat menemukan toko oleh-oleh dan oleh-oleh secara bersamaan berdasarkan rute perjalanan. Selain itu, aplikasi ini,memberikan keuntungan kepada para pemilik toko oleh-oleh untuk menjual oleh-oleh secara online. Serta beberapa fitur yang menunjang proses jual-beli.
PENGEMBANGAN SISTEM CERDAS MENGGUNAKAN PENALARAN BERBASIS KASUS (CASE BASED REASONING) UNTUK DIAGNOSA PENYAKIT AKIBAT VIRUS EKSANTEMA
Authors: Aribowo Agus Sasmito 
Published: September 2019

Disease caused by a exanthema virus is a common disease in Indonesia. There are many types of diseases caused by this virus. Examples are chicken pox, measles, variola, etc. with symptoms almost similar to each other. To correctly identify the symptoms need experts. But the problem is very limited number of experts. Then the expert system is needed which has been given by the expert knowledge to assist in the diagnosis. Expert system in this research uses a case-based reasoning approach. If there is a similar case, the reasoning for considering the case of the nearest using Probabilistic Bayes. The result is the system will still be able to provide the best recommendations solution for new cases based on the solution to an old case that the nearest level of similarity.
NORMATIVE-METHODICAL SUPPORT OF THE EDUCATIONAL PROCESS AT UNIVERSITY IN TERMS OF E-LEARNING
Authors: Kalmykova S. V. 
Published: September 2019

The article summarizes the experience of Peter the Great St. Petersburg Polytechnic University (SPbPU) in changing the regulatory and methodological support of the educational process in the context of e-learning. The models of involvement of mass open online courses (MOOCs) in the educational process of the university are considered. The author draws on practical experience and the results of an experiment implemented in 2016–2019 at Peter the Great St. Petersburg Polytechnic University, which allowed to include online courses in 100 % of the curriculum by the beginning of the 2018/2019 academic year. The analysis of the necessary local regulations, allowing to begin the active integration of online courses in the educational process. The necessity of classification of electronic educational resources within the university is substantiated. The possibility of using e-learning for the organization of project work is substantiated. A detailed description of the components of educational resources, which allowed to implement common requirements for their implementation in the educational process is given.
FEATURES OF THE ORGANIZATION AND CONDUCT OF ТHE CONTEST OF TASKS ON CYBERSECURITY
Authors: Troitskaya O. N. , Bezumova O. L. , Shirikova T. S. 
Published: September 2019

Preparing children for safe behavior on the Internet is one of the most important tasks of secondary school, which is recognized at the state level. It is confirmed by the order of the Government of the Russian Federation of December 2, 2015 "Concept of Information Security of Children for 2018–2020" and the order of the Ministry of Digital Development, Communications and Mass Media of the Russian Federation of February 27, 2018 "On Approval of the Action Plan for the Implementation of the Concept of Information Security of Children for 2018–2020". The First Region Week of Cybersecurity was held as part of the implementation of this plan in October 2018 in the Arkhangelsk region. The article is devoted to the description of one of the events of this week — the contest of tasks on cybersecurity. The article presents the conceptual basis for the development of a system of competitive tasks, which were offered to schoolchildren of different classes of secondary school, and provides examples of problems with solutions. The authors of the article believe that the inclusion of such tasks in the content of school computer science textbooks will give teachers really effective tools to prepare schoolchildren for recognizing cyberthreats and the correct behavior when meeting with them.
Retos de los Programas Académicos en la Modalidad Virtual para Obtener la Acreditación
Authors: Navarro F.G. Navarro , Fernández M.R. Moreno , Báez A. Garcés , Colorado E. Mora 
Published: September 2019

La cuarta revolución también conocida como Industria 4.0 o revolución industrial etapa cuatro ha provocado enormes cambios en la educación, es por ello que los organismos acreditadores se han visto en la necesidad de orientar sus instrumentos de evaluación para que permitan evaluar programas académicos en modalidad virtual. La presente investigación tiene como objetivo identificar, analizar y señalar los retos de los programas académicos en la modalidad virtual para obtener la acreditación; para ello fue necesario identificar el contexto actual de la acreditación de programas académicos en dicha modalidad, identificando los principales organismos acreditadores, así como los criterios importantes a evaluar por los organismos acreditadores para los programas de tecnologías de información y comunicación en la modalidad virtual y finalmente señalar los principales retos a los que se enfrentan los programas académicos en modalidad virtual.
The fourth revolution also known as Industry 4.0 or industrial revolution stage four has brought about enormous changes in education, which is why the accrediting associations have found themselves in need of guiding their evaluation instruments so that they can evaluate academic programs in virtual modality. The objective of this research is to identify, analyze and identify the challenges of academic programs in the virtual modality to obtain accreditation; for them it was necessary to identify the current context of accreditation of academic programs in this modality, identifying the main accrediting associations, as well as the important criteria to be evaluated by the accrediting associations for the informationtechnology and communication programs in the virtual modality and finally pointing out the main challenges faced by the academic programs in virtual modality.
Control de calidad y análisis fisicoquímicos en la cadena productiva de la leche de la parroquia El Triunfo del cantón Pastaza
Authors: Barrazueta Rojas Sandra Gabriela , Quintana Unda Ronny Alexander , Mendoza Zurita Guillermo Xavier , Oleas López Julio Mauricio 
Published: September 2019

La leche es un alimento básico en la dieta de los consumidores, lo que convierte a este alimento en uno de los más consumidos. Ecuador produce 5’100.000 litros de leche diarios y la región oriente tiene el 8.79% del total de la producción. Actualmente se ha implementado centros de acopio en la provincia de Pastaza con el objetivo de incentivar a la producción de leche de calidad, por lo mencionado anteriormente el propósito de este trabajo fue determinar la calidad de la leche en la cadena productiva del centro de acopio de la parroquia el Triunfo de la provincia de Pastaza, para ello se tomaron muestras de 33 productores activos de la zona; para el levantamiento de la información se tomó en cuenta: cantidad de producción, condiciones del ordeño y transporte, para ello se contó con el apoyo del MAGAP de Pastaza. El análisis de las muestras se lo realizó en el laboratorio del centro de acopio donde se analizó los parámetros físico-químicos y bromatológicos de la leche según indica la norma INEN 9:2012. Las variables evaluadas fueron: densidad, pH, temperatura, materia grasa, acidez titulable, sólidos totales, sólidos no grasos, proteínas, estabilidad proteica, punto crioscópico y mastitis. Los resultados obtenidos indicaron que la leche del centro de acopio de la parroquia el Triunfo en su mayoría se encuentra dentro de los parámetros establecidos por la norma, pero existen muestras que están fuera de los rangos establecidos, además se determinó que la alimentación, el transporte, condiciones ambientales y manejo del animal tienen efecto sobre la calidad de la leche.
TÜRKİYE’DE DOMATES ÜRETİMİNDE İÇ TİCARET HADLERİ
Authors: MENCET YELBOĞA Makbule Nisa , SAYIN Cengiz , ERYİĞİT Fatma Dilek 
Published: September 2019

Türkiye, uzun yıllardır enflasyon
ile mücadele eden ülkeler arasında yer almakta olup enflasyon tarım sektörünü
de etkisi altına almaktadır. Enflasyonun etkisini anlamak ve dolayısıyla
Sektörler arasındaki kaynak transferinin durumu ve yönünün yıllar itibariyle
belirlenmesi açısından iç ticaret hadleri önem taşımaktadır. İç ticaret
hadleri, tarım sektöründen tarım dışı sektörlere kaynak aktarımını
göstermektedir. Böyle bu yöntemle, sektörel olarak ekonomik refah değişmelerini
takip etmek ve tarım kesiminin satın alma gücündeki değişiklikleri anlamak
mümkün olmaktadır. İç ticaret hadlerinin tarımın aleyhine gelişmesi tarımın
diğer sektörler tarafından vergilenmesini, lehine gerçekleşmesi ise tarım dışı
sektörlerden tarıma kaynak aktarımını göstermektedir. Sektörler arası fiyat
değişimleri ve seyri, tarım politikaları kapsamında desteklemelerin ve
teşviklerin belirlenmesini de etkilemektedir. Bu çalışmada, Türkiye’de
2003-2017 döneminde domateste iç ticaret hadlerini hesaplayarak üreticilerinin
satın alma gücünü hesaplamak ve yorumlamak amaçlanmıştır. İç ticaret
hadleri net değişim hadleri kapsamında; domates üretim girdi fiyatları, çiftçi
eline geçen fiyat ve tüketici fiyat indeksine göre 2003 yılı baz alınarak
hesaplanmıştır. Çalışmada, incelenen dönem içerisinde tarım ticaret
hadleri üretici lehine seyir izlemesine rağmen domates üreticisi için aleyhine
bir seyir izlemiştir. Bu durum çiftçi ürettiği tarımsal üründen eline geçen
fiyatlar ile daha az tarım dışı mal ve hizmet alabileceği anlamına gelmektedir.