bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Device used in Selective Withdrawal from Reservoirs and its Effectiveness Verified in Computational Fluid Dynamics
Authors: Lu Jinsuo , Zhang Wei , Wang Dengyu , Wang Xiaoyi 
Published: March 2018

Water intake with fixed height limits the application of selective withdrawal technology in a certain degree. This study proposes a technological idea to install baffles on water intake. Through the rotation of upper and lower baffle, poor water layer can be blocked. A Computational Fluid Dynamics (CFD) model for the upper baffle on water intake is constructed. The results show that the baffle installed on the upper part of orifice can reduce the withdrawal layer thickness and flow on the upper part of orifice centre. Thereby, the withdrawal flow on lower part can be indirectly increased. While, baffle length and inclining angle are the important factors to influence the withdrawal layer thickness and flow distribution. Therefore, the adjusting range of selective withdrawal can be economically enhanced by installing baffles on water intake.
Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype
Authors: Suárez-Fueyo Abel , Bradley Sean J. , Katsuyama Takayuki , Solomon Sarah , Katsuyama Eri , Kyttaris Vasileios C. , Moulton Vaishali R. , Tsokos George C. 
Published: March 2018

Abstract
Cytotoxic function and cytokine profile of NK cells are compromised in patients with systemic lupus erythematosus (SLE). CD3ζ, an important molecule for NK cell activation, is downregulated in SLE T cells and contributes to their altered function. However, little is known about the role of CD3ζ in SLE NK cells. We studied CD3ζ levels and its contribution to cytotoxic, degranulation, and cytokine production capacity of NK cells from patients with SLE. Furthermore, we studied the human NK cell line, NKL, in which manipulation of CD3ζ levels was achieved using small interfering RNA and NK cells from Rag2 mice deficient in CD3ζ. We found reduced CD3ζ expression in NK cells from SLE patients independent of disease activity. Downregulation of CD3ζ expression in NK cells is mediated, at least in part, by Caspase 3, the activity of which is higher in NK cells from patients with SLE compared with NK cells from healthy donors. CD3ζ levels correlated inversely with natural cytotoxicity and the percentage of cells capable of producing the proinflammatory cytokines IFN-γ and TNF. In contrast, CD3ζ levels showed a direct correlation with levels of Ab-dependent cellular cytotoxicity. Experiments performed in CD3ζ-silenced NKL and CD3ζ-deficient NK cells from Rag2 mice confirmed the dependence of NK cell function on CD3ζ levels. Our results demonstrate a differential role for CD3ζ in natural cytotoxicity and Ab-dependent cellular cytotoxicity. We conclude that downregulated CD3ζ confers a proinflammatory phenotype to SLE NK cells and contributes to their altered function in patients with SLE.
Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming
Authors: Elliott Eric I. , Miller Alexis N. , Banoth Balaji , Iyer Shankar S. , Stotland Aleksandr , Weiss Jerrold P. , Gottlieb Roberta A. , Sutterwala Fayyaz S. , Cassel Suzanne L. 
Published: March 2018

Abstract
The NLRP3 inflammasome is activated in response to microbial and danger signals, resulting in caspase-1–dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Canonical NLRP3 inflammasome activation is a two-step process requiring both priming and activation signals. During inflammasome activation, NLRP3 associates with mitochondria; however, the role for this interaction is unclear. In this article, we show that mouse NLRP3 and caspase-1 independently interact with the mitochondrial lipid cardiolipin, which is externalized to the outer mitochondrial membrane at priming in response to reactive oxygen species. An NLRP3 activation signal is then required for the calcium-dependent association of the adaptor molecule ASC with NLRP3 on the mitochondrial surface, resulting in inflammasome complex assembly and activation. These findings demonstrate a novel lipid interaction for caspase-1 and identify a role for mitochondria as supramolecular organizing centers in the assembly and activation of the NLRP3 inflammasome.
A Call to Reexamine Quality of Life Through Relationship-Based Feeding
Authors: Henton Patricia A. 
Published: March 2018

Abstract
Feeding interventions that support family relationships enhance children’s daily participation in meaningful occupations at home. A critical review of the literature yielded several premises that support the development of a relationship-based feeding framework. The proposed theoretical framework, based on the Biopsychosocial Model of Pediatric Feeding (Berlin, Davies, Lobato, & Silverman, 2009) and the Ecological Model of Occupation (Dunn, Brown, & Youngstrom, 2003), is presented to guide feeding interventions for children with significant feeding difficulties. A case example that illustrates the practical application of this framework is provided. Further development of relationship-based feeding theory and research is recommended to improve the occupational performance and quality-of-life outcomes for children and their families.
Higher Education Leadership Training: Global Maps and Gaps
Authors: Rumbley Laura , Van't Land Hilligje , Becker Juliette 
Published: March 2018

Globally, most higher education leaders, managers, and policymakers receive no formal/specialized training for their work. Compared to the need, there is a relatively small number of structured training opportunities that exist to build leadership and management capacity in higher education around the world. These training programs are almost universally small in scale and largely unable to offer systematic accounts ofthe long-term impact of their efforts. This is a critical concern in the face of the myriad opportunities and imperatives facing higher education institutions and systems worldwide—particularly in low-income and emerging economy contexts—now and into the foreseeable future.
Income-Contingent Loans: Not a Miracle Solution
Authors: De Gayardon Ariane 
Published: March 2018

With the rising costs of higher education, an increasing share of which is borne by students and their families, governments have had to design student loans schemes to open higher education to all. A popular option among economists is income-contingent loans, where repayment is calculated as a share of the borrower’s income to avoid high repayment burden. However, the three flagship countries forincome-contingent loans—Australia, England, and New Zealand—are all currently experiencing financing issues. This raises the question of defining the correct specification of income-contingent loans schemes, as well as finding the proper balance between different financial aid policies.
Glycaemic control in type 2 diabetic patients with chronic kidney disease: the impacts on enzymatic antioxidants and soluble RAGE
Authors: Wong Foo Nian , Chua Kek Heng , Tan Jin Ai Mary Anne , Wong Chew Ming , Kuppusamy Umah Rani 
Published: March 2018

Background
Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development and progression of the disease. Glycaemic control slows down the progression of diabetic complications, including diabetic CKD. However, the implication of glycaemic control on enzymatic antioxidants and soluble RAGE (sRAGE) in CKD patients remains elusive. The aim of this study was to investigate the effect of glycaemic control on the levels or activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and sRAGE in CKD patients.

Methods
A total of 150 CKD patients and 64 non-CKD patients were enrolled. The type 2 diabetic patients in the recruited study participants were categorised based on their glycaemic control; poor glycaemic control (GC) with haemoglobin A1c (HbA1c) > 7% and good GC with HbA1c ≤ 7%. The levels or activities of GPx, SOD and sRAGE in plasma were measured. These biochemical parameters were analysed using Mann–Whitney U test and two-way analysis of variance (ANOVA).

Results
The activities of GPx and SOD as well as plasma level of sRAGE were not significantly different among the CKD patients with varying glycaemic control status. Irrespective of diabetes status and glycaemic control status, CKD patients also exhibited lower plasma SOD activities compared with non-CKD patients. Among the non-CKD patients, SOD activities were significantly higher in diabetic patients with good GC than diabetic patients with poor GC. Two-way ANOVA revealed that both CKD status and glycaemic control had an interaction effect on SOD activities in diabetic subjects with and without CKD. Follow-up analysis showed that SOD activities were significantly higher in non-CKD patients with good GC. There were no overall significant differences in GPx activities among the study participants. Furthermore, plasma sRAGE levels were higher in diabetic patients with CKD than those without CKD, regardless of glycaemic control status. There were no interaction effects between CKD status and glycaemic control status on GPx and sRAGE. Instead, CKD status showed significant main effects on these parameters, indicating significant differences between diabetic subjects with CKD and diabetic subjects without CKD.

Conclusion
Glycaemic control did not quantitatively alter GPx, SOD and sRAGE in diabetic CKD patients. Despite the advantages of good glycaemic control, a well-controlled diabetes in CKD did not modulate the activities of enzymatic antioxidants and sRAGE levels, therefore may not be the primary mechanism to handle oxidative stress.
In Situ Temperature Measurements at the Svalbard Continental Margin: Implications for Gas Hydrate Dynamics
Authors: Riedel M. , Wallmann K. , Berndt C. , Pape T. , Freudenthal T. , Bergenthal M. , Bünz S. , Bohrmann G. 
Published: March 2018

AbstractDuring expedition MARIA S. MERIAN MSM57/2 to the Svalbard margin offshore Prins Karls Forland, the seafloor drill rig MARUM‐MeBo70 was used to assess the landward termination of the gas hydrate system in water depths between 340 and 446 m. The study region shows abundant seafloor gas vents, clustered at a water depth of ∼400 m. The sedimentary environment within the upper 100 m below seafloor (mbsf) is dominated by ice‐berg scours and glacial unconformities. Sediments cored included glacial diamictons and sheet‐sands interbedded with mud. Seismic data show a bottom simulating reflector terminating ∼30 km seaward in ∼760 m water depth before it reaches the theoretical limit of the gas hydrate stability zone (GHSZ) at the drilling transect. We present results of the first in situ temperature measurements conducted with MeBo70 down to 28 mbsf. The data yield temperature gradients between ∼38°C km−1 at the deepest site (446 m) and ∼41°C km−1 at a shallower drill site (390 m). These data constrain combined with in situ pore‐fluid data, sediment porosities, and thermal conductivities the dynamic evolution of the GHSZ during the past 70 years for which bottom water temperature records exist. Gas hydrate is not stable in the sediments at sites shallower than 390 m water depth at the time of acquisition (August 2016). Only at the drill site in 446 m water depth, favorable gas hydrate stability conditions are met (maximum vertical extent of ∼60 mbsf); however, coring did not encounter any gas hydrates.
Reef Carbonate Productivity During Quaternary Sea Level Oscillations
Authors: Husson L. , Pastier A.‐M. , Pedoja K. , Elliot M. , Paillard D. , Authemayou C. , Sarr A.‐C. , Schmitt A. , Cahyarini S. Y. 
Published: March 2018

AbstractGlobal variations in reef productivity during the Quaternary depend on external parameters that may alter the global chemical balance in the oceans and atmosphere. We designed a numerical model that simulates reef growth, erosion, and sedimentation on coastlines undergoing sea level oscillations, and uplift or subsidence. We further develop a probabilistic evaluation that accounts for variable vertical ground motion, erosion, and foundation morphologies. Absolute sea level change appears primordial, as productivity must have increased by an order of magnitude since the onset of the glacial cycles, ∼2.6 Ma. But most important is relative sea level change, i.e., eustasy modulated by uplift or subsidence, that rejuvenates the accommodation space and exposes pristine domains of the shore to active reefs at each cycle. Integrated over the long‐term, vertical land motion sets the pace of reef growth: productivity in tectonically unstable domains is thus expected to be up to 10 times higher than in stable regions, if any. We quantify the global length of reef coasts and the probability density functions for slopes and uplift rates. Productivity waxes during transgressions to reach 2–8
and wanes during highstands, which may contribute to increase atmospheric pCO2 by several tens of ppm during deglaciations. Over the last 1.5 Ma, reefs precipitated ∼0.8 × 106
(∼500 × 103 km3), the equivalent of a 1 m‐thick layer spread over the entire surface of the Earth. This production modulates the calcium budget, for it represents some 30% of the modern Ca flux in the ocean.
CEmin: A MATLAB‐Based Software for Computational Phenocryst Extraction and Statistical Petrology
Authors: Zeng Ling , Cheng Lilu , Costa Fidel , Herrin Jason 
Published: March 2018

AbstractIt is nowadays common to collect large‐area backscattered electron images and X‐ray maps of entire standard petrographic thin sections. These images can be calibrated for compositions of some minerals (e.g., plagioclase) with a small number of electron microprobe analyses, and thus provide a wealth of quantitative data for hundreds of crystals. However, to effectively make use of the textures and compositions of large numbers of crystals we need to be able to efficiently outline and segregate the crystals of interest from the rest of the sample. Here we present CEmin, a set of MATLAB routines that are user‐friendly and allow users to semiautomatically separate plagioclase crystals in grayscale images of volcanic rocks for further processing. These data can then be used for textural and chemical zoning studies. Efficiently extracting large amounts of crystal data allows for identification of plagioclase populations that are indicative of magmatic processes (e.g., closed versus open system) and statistical comparison to thermodynamic models.
Variations in the Iron Mineralogy of a Loess Section in Tajikistan During the Mid‐Pleistocene and Late Pleistocene: Implications for the Climatic Evolution in Central Asia
Authors: Jia Jia , Lu Hao , Wang Youjun , Xia Dunsheng 
Published: March 2018

AbstractThe loess sequences in Tajikistan are an important archive of information about the development of climate and atmospheric circulation in central Asia during the Pleistocene. Here we present the results of an iron mineralogical study of a loess sequence in Tajikistan to reconstruct paleoclimate evolution during the mid‐Pleistocene and late Pleistocene. The record indicates that interglacial intervals were relatively humid and glacials were dry. We propose a shift in the character of the interglacial climate of the region to more humid after beginning of MIS 9; however, temperature was relatively stable. The location and intensity of Westerlies have a close link with Asian Summer Monsoon (ASM) circulations. From the beginning of MIS 9, there was a southward movement of the Westerlies circulation, which corresponded to a retreat of the Indian Summer Monsoon (ISM). A similar relationship also existed between the East Asian Summer Monsoon (EASM) circulation and the Westerlies, which is evidenced by the formation of the most weakly developed soil unit in the EASM‐dominated regions during MIS 9, in contrast with the formation of the most strongly developed soil unit in the Westerlies‐dominated regions. As conditions in the areas of loess deposition became more humid, the sedimentary basins which are the dust source areas became progressively more arid. The aridification of the source areas may be the result of increased Northern Hemisphere ice volume and accelerated high mountains and/or plateaus uplift in the surrounding regions.
Origin of Light Noble Gases (He, Ne, and Ar) on Earth: A Review
Authors: Péron Sandrine , Moreira Manuel , Agranier Arnaud 
Published: March 2018

AbstractWe review the different scenarios for the origin of light noble gases (He, Ne, and Ar) on Earth. Several sources could have contributed to the Earth's noble gas budget: implanted solar wind, solar nebula gas, chondrites, and comets. Although there is evidence for “solar‐like” neon in the Earth's mantle, questions remain as to its origin. A new compilation of noble gas data in lunar soils, interplanetary dust particles, micrometeorites, and solar wind allows examination of the implanted solar wind composition, which is key to understanding the “solar‐like” mantle neon isotope composition. We show that lunar soils that reflect this solar‐wind‐implanted signature have a 20Ne/22Ne ratio very close to that of ocean island basalts. New data and calculations illustrate that the measured plume source 20Ne/22Ne ratio is close to the primitive mantle ratio, when taking into account mixing with the upper mantle (that has lower 20Ne/22Ne ratio). This favors early solar wind implantation to account for the origin of light volatiles (He, Ne, and possibly H) in the Earth's mantle: they were incorporated by solar wind irradiation into the Earth's precursor grains during the first few Myr of the solar system's formation. These grains must have partially survived accretion processes (only a few percent are needed to satisfy the Earth's budget of light volatiles). As for the atmosphere, the neon isotope composition can be explained by mixing 36% of mantle gases having this solar‐wind‐implanted signature and 64% of chondritic gases delivered in a late veneer phase.
Properties of the HPS‐ICME‐CIR Interaction Event of 9–10 September 2011
Authors: Al‐Shakarchi Duraid A. , Morgan Huw 
Published: March 2018

AbstractDuring 9–10 September 2011 the ACE, Wind, and SOHO spacecraft measured the complex interaction between an interplanetary coronal mass ejection (ICME) and a corotating interaction region (CIR) associated with the heliospheric sector boundary. Except for a few short periods, the suprathermal electrons are unidirectional, suggesting that the ICME magnetic field has opened through interchange reconnection. Signatures of interaction are distributed throughout the event suggesting that the structures have become entangled or embedded. Since the ICME speed is relatively low, the strong forward shock must be caused by the ICME‐CIR interaction. Other interesting features are the upstream heating flux discontinuity, the very high proton density in the frontal boundary of the heliospheric plasma sheet and the forward shock, the significant speed elevation within the sheath, the distortion of Bz in the magnetic cloud, the indistinct location of the stream interface, the unidirectional domination of the suprathermal electrons, and the reverse shock at the CIR rear boundary. There is an unusual delay between the proton density and temperature profiles. Furthermore, large differences in proton speed and forward shock density measured between L1 spacecraft indicate high variation at small spatial scales. A few days earlier, STEREO B recorded the undisturbed CIR, which shows that (i) some general features of the CIR are preserved, (ii) the CIR is compressed by a factor of ∼4 by the ICME, and (iii) a magnetic exhausted region at the front of the CIR is a continuous feature and is not formed due to the ICME interaction.
Representing Precipitation Ice Species With Both Spherical and Nonspherical Particles for Radiative Transfer Modeling of Microphysics‐Consistent Cloud Microwave Scattering Properties
Authors: Sieron Scott B. , Zhang Fuqing , Clothiaux Eugene E. , Zhang Lily N. , Lu Yinghui 
Published: March 2018

AbstractCloud microwave scattering properties for the Community Radiative Transfer Model (CRTM) have previously been created to be consistent with the particle size distributions specified by the WSM6 single‐moment microphysics scheme. Here substitution of soft sphere scattering properties with nonspherical particle scattering properties is explored in studies of Hurricane Karl (2010). A nonsphere replaces a sphere of the same maximum dimension, and the number of particles of a given size is scaled by the ratio of the sphere to nonsphere mass to keep the total mass of a given particle size unchanged. The replacement of homogeneous soft sphere snow particles is necessary to resolve a highly evident issue in CRTM simulations: precipitation‐affected brightness temperatures are generally warmer at 183 GHz than at 91.7 GHz, whereas the reverse is seen in observations. Using sector snowflakes resolve this issue better than using columns/plates, bullet rosettes, or dendrites. With sector snowflakes, both of these high frequencies have low simulated brightness temperatures compared to observations, providing a clear and consistent suggestion that snow is being overproduced in the examined simulation using WSM6 microphysics. Graupel causes cold biases at lower frequencies which can be reduced by either reducing graupel water contents or replacing the microphysics‐consistent spherical graupel particles with sector snowflakes. However, soft spheres are likely the better physical representation of graupel particles. The hypotheses that snow and graupel are overproduced in simulations using WSM6 microphysics shall be examined more systematically in future studies through additional cases and ensemble data assimilation of all‐sky microwave radiance observations.
Salt Precipitation in Ultratight Porous Media and Its Impact on Pore Connectivity and Hydraulic Conductivity
Authors: Alizadeh A. H. , Akbarabadi M. , Barsotti E. , Piri M. , Fishman N. , Nagarajan N. 
Published: March 2018

AbstractThe degree of salt precipitation and its impact on fluid flow in ultratight porous media are investigated in three preserved core plugs selected from two different wells in an unconventional hydrocarbon reservoir. Small specimens are cut from the core plugs and then imaged using a focused ion beam scanning electron microscope (FIB‐SEM) to detect any salt precipitation in the pore space. The SEM results show that salt covers the pore walls and either partially or fully blocks pore elements, making some parts of the pore space inaccessible to flow. To examine the effect of salt removal on fluid flow, one of the core plugs is subjected to a cleaning process. The plug is initially saturated with methanol, and then methanol is continuously injected into the sample while the effluent is periodically titrated using silver nitrate to monitor salt removal. The variation of the salinity of the methanol effluent with time, the decrease in the pressure drop across the core, and the increased permeability to methanol indicated the effectiveness of the cleaning process. The successful removal of salt from the sample prompts the adoption of a new workflow for preparing tight rock samples for laboratory experiments.