bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Cardiovascular Risk Factors With Cardiac Events and Survival Outcomes Among Patients With Breast Cancer Enrolled in SWOG Clinical Trials
Authors: Hershman Dawn L. , Till Cathee , Shen Sherry , Wright Jason D. , Ramsey Scott D. , Barlow William E. , Unger Joseph M. 
Published: March 2018

Background Cardiovascular disease is the primary cause of death among patients with breast cancer. However, the association of cardiovascular-disease risk factors (CVD-RFs) with long-term survival and cardiac events is not well studied. Methods We examined SWOG (formerly the Southwest Oncology Group) breast cancer trials from 1999 to 2011. We identified baseline diabetes, hypertension, hypercholesterolemia, and coronary artery disease by linking trial records to Medicare claims. The primary outcome was overall survival. Patients with both baseline and follow-up claims were examined for cardiac events. Cox regression was used to assess the association between CVD-RFs and outcomes. Results We identified 1,460 participants older than 66 years of age from five trials; 842 were eligible for survival outcomes analysis. At baseline, median age was 70 years, and median follow-up was 6 years. Hypertension (73%) and hypercholesterolemia (57%) were the most prevalent conditions; 87% of patients had one or more CVD-RF. There was no association between any of the individual CVD-RFs and overall survival except for hypercholesterolemia, which was associated with improved overall survival (hazard ratio [HR], 0.73; 95% CI, 0.57 to 0.93; P = .01). With each additional CVD-RF, there was an increased risk of death (HR, 1.23; 95% CI, 1.08 to 1.40; P = .002), worse progression-free survival (HR, 1.12; 95% CI, 1.00 to 1.25; P = .05), and marginally worse cancer-free survival (HR, 1.15; 95% CI, 0.99 to 1.34; P = .07). The relationship between baseline CVD-RFs and cardiac events was analyzed in 736 patients. A strong linear association between the number of CVD-RFs and cardiac event was observed (HR per CVD-RF, 1.41; 95% CI, 1.17 to 1.69; P < .001). Conclusion Among participants in clinical trials, each additional baseline CVD-RF was associated with an increased risk of cardiac events and death. Efforts to improve control of modifiable CVD-RFs are needed, especially among those with multiple risk factors.
Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission
Authors: Dema Alessandro , Macaluso Francesca , Sgrò Francesco , Berto Gaia E. , Bianchi Federico T. , Chiotto Alessandra A. , Pallavicini Gianmarco , Di Cunto Ferdinando , Gai Marta 
Published: March 2018

ABSTRACT
Abscission is the final step of cytokinesis whereby the intercellular bridge (ICB) linking the two daughter cells is cut. The ICB contains a structure called the midbody, required for the recruitment and organization of the abscission machinery. Final midbody severing is mediated by formation of secondary midbody ingression sites, where the ESCRT III component CHMP4B is recruited to mediate membrane fusion. It is presently unknown how cytoskeletal elements cooperate with CHMP4B to mediate abscission. Here, we show that F-actin is associated with midbody secondary sites and is necessary for abscission. F-actin localization at secondary sites depends on the activity of RhoA and on the abscission regulator citron kinase (CITK). CITK depletion accelerates loss of F-actin proteins at the midbody and subsequent cytokinesis defects are reversed by restoring actin polymerization. Conversely, midbody hyperstabilization produced by overexpression of CITK and ANLN is reversed by actin depolymerization. CITK is required for localization of F-actin and ANLN at the abscission sites, as well as for CHMP4B recruitment. These results indicate that control of actin dynamics downstream of CITK prepares the abscission site for the final cut.
Determining paediatric patient thickness from a single digital radiograph—a proof of principle
Authors: Worrall Mark , Vinnicombe Sarah , Sutton David G 
Published: March 2018

Objective: This work presents a proof of principle for a method of estimating the thickness of an attenuator from a single radiograph using the image, the exposure factors with which it was acquired and a priori knowledge of the characteristics of the X-ray unit and detector used for the exposure. It is intended this could be developed into a clinical tool to assist with paediatric patient dose audit, for which a measurement of patient size is required. Methods: The proof of principle used measured pixel value and effective linear attenuation coefficient to estimate the thickness of a Solid Water attenuator. The kerma at the detector was estimated using a measurement of pixel value on the image and measured detector calibrations. The initial kerma was estimated using a lookup table of measured output values. The effective linear attenuation coefficient was measured for Solid Water at varying kVp. 11 test images of known and varying thicknesses of Solid Water were acquired at 60, 70 and 81 kVp. Estimates of attenuator thickness were made using the model and the results compared to the known thickness. Results: Estimates of attenuator thickness made using the model differed from the known thickness by 3.8 mm (3.2%) on average, with a range of 0.5–10.8 mm (0.5–9%). Conclusion: A proof of principle is presented for a method of estimating the thickness of an attenuator using a single radiograph of the attenuator. The method has been shown to be accurate using a Solid Water attenuator, with a maximum difference between estimated and known attenuator thickness of 10.8 mm (9%). The method shows promise as a clinical tool for estimating abdominal paediatric patient thickness for paediatric patient dose audit, and is only contingent on the type of data routinely collected by Medical Physics departments. Advances in knowledge: A computational model has been created that is capable of accurately estimating the thickness of a uniform attenuator using only the radiographic image, the exposure factors with which it was acquired and a priori knowledge of the characteristics of the X-ray unit and detector used for the exposure.
Metodologiczne dylematy i pułapki pojęcia polityczności
Authors: Karwat Mirosław 
Published: March 2018

Methodological dilemmas and traps of the concept “political”
A theorist defining the concept “political” needs to decide many methodological dilemmas and evade some disasters and traps, especially elementary mistakes, errors or simplifications. The distinction between the concept of “politics” and the concept of “the political” may be stereotypical, even completely popular, colloquial. However, the terminological similarity and grammatical connection between the noun and adjective or adverb result in definition difficulties. The contrary solution of the variety problem consists in the separate meaning of both concepts. Among the typical temptations for a theorist one could find the following: ontological naturalism, formalism, simple essentialism, reduction of both concepts, illusion of self‑contained political being, ignoring the historical context, syndromatic nature and relativity of the “politicality”.
EDUCACIÓN COMPARADA EN AMÉRICA LATINA. EL CASO DE LA EDUCACIÓN ALTERNATIVA EN OAXACA: MATEMÁTICAS Y PRÁCTICA SOCIAL
Authors: Cantoral Uriza Dr. Ricardo 
Published: March 2018

En este año dedicaremos las editoriales de la Revista Latinoamericana de Investigación en Matemática Educativa (Relime), para presentar tres experiencias de éxito de programas de maestría en Matemática Educativa, o en sus versiones equivalentes, que hayan logrado trascender del trabajo académico propio de un posgrado a la acción comunitaria con incidencia social. Se presentarán aspectos cualitativos de tres casos de interés con el propósito de estimular el intercambio entre cuerpos académicos. El plan es mostrar el programa de Maestría en Enseñanza de las Matemáticas de la Educación Secundaria (memes) de la Escuela Normal Superior Federal de Oaxaca (ensfo), para mayores detalles consultar (Vásquez, 2016). Posteriormente daremos lugar al programa del Departamento de Matemática de la Universidad de Camagüey Ignacio Agramonte Loynaz, en Cuba. Concluiremos este volumen con una presentación de los logros del programa de maestría del Instituto de Matemáticas de la Pontificia Universidad Católica de Valparaíso, en Chile.
Adequação da dieta hospitalar: Associação com estado nutricional e diagnóstico clínico
Authors: Ribas Simone Augusta , Barbosa Bárbara Cristina M. 
Published: March 2018

Introdução: O comprometimento do estado nutricional é bastante comum entre pacientes hospitalizados, e a detecção precoce permite ajustar a dieta hospitalar para necessidades energéticas e protéicas desses pacientes. Objetivos: Investigar a adequação da dieta hospitalar e sua relação com o estado nutricional de pacientes internados em um Hospital Universitário. Métodos: Participaram deste estudo descritivo, prospectivo e transversal, 1568 pacientes. Foram investigados aspectos relacionados ao diagnóstico clínico, estado nutricional, requerimento energético, qualidade da dieta e adequação nutricional. Resultados: Pode-se constatar a partir das variáveis analisadas, que o diagnóstico clínico, o estado nutricional, o tipo de dieta prescrita, a aceitação e a adequação nutricional da dieta, diferiram por gênero (p≤0,001). Duas extremidades do desvio nutricional foram encontradas entre os pacientes: desnutrição (20,3%) e excesso de peso (35,0%). A dieta hospitalar foi avaliada como ‘boa a excelente’ em 85,7% dos casos. Pacientes com baixo peso apresentaram maior aceitação da dieta hospitalar em comparação com pacientes com sobrepeso [OR = 3,19; p<0,001 (café da manhã e lanches); OR = 2,2; p= 0,02 (almoço e jantar)]. Também foi observado que pacientes do sexo feminino e afetados por doenças do aparelho geniturinário foi o grupo com o menor grau de aceitação da dieta e os do sexo masculino afetados por doenças infecciosas e do aparelho circulatório apresentaram maior proporção de comprometimento nutricional, respectivamente. Conclusões: A dieta hospitalar fornecida atendeu a maioria da sua clientela, porém ainda precisa de ajustes dietéticos para os pacientes que recebem dieta hipossódica e para os que apresentam alta demanda energética. Descritores: Estado nutricional; Dieta; Pacientes hospitalizados.
Formulação de nhoque isento de glúten enriquecido com biomassa de banana verde
Authors: Santos Arabelle S. , Rezende Antônio José , Oliveira Célia Regina A. , Fortes Renata C. 
Published: March 2018

Introdução: A doença celíaca é uma intolerância permanente ao glúten, caracterizada por atrofia total ou subtotal da mucosa do intestino delgado e consequente má absorção de alimentos. A única forma de tratamento da doença celíaca é a exclusão do glúten da dieta. A adesão ao tratamento não constitui prática fácil, pela dificuldade do indivíduo em se adaptar aos alimentos modificados que possuem prejuízos nas características sensoriais. Nesse contexto, é importante o desenvolvimento de alimentos isentos de glúten com boas características sensoriais e nutricionais. Objetivos: Desenvolver nhoque isento de glúten, com adição de biomassa de banana verde. Métodos: Trata-se de um estudo experimental no qual foram realizadas análises sensoriais de nhoque sem glúten, acrescido de biomassa de banana verde. Foi aplicado teste de aceitação, utilizando-se uma escala hedônica de nove pontos. Resultados: O nhoque apresentou boa aceitabilidade, sendo igual ou superior a 70% nos atributos aroma, sabor, textura e aceitação global. Já nos atributos aparência e cor a aceitação chegou a 60%. Conclusões: A análise sensorial mostrou boa aceitação da preparação, em torno de 80%, contribuindo com uma alternativa alimentar de baixo custo e com boas características sensoriais para indivíduos com a doença celíaca e àqueles que requerem dieta com restrição ao glúten.Descritores: Biomassa; Musa; Dieta livre de glúten; Doença celíaca.
Adverse Childhood Experiences Among Direct Support Professionals
Authors: Keesler John M. 
Published: March 2018

Abstract
Direct support professionals (DSPs) provide integral support to many individuals with intellectual and developmental disabilities (IDD). Yet, individuals' access to qualified DSPs is often compromised as organizations struggle to hire and retain DSPs. Despite a vast body of research exploring factors associated with turnover, adverse childhood experiences (ACEs) among DSPs remain absent from the literature. ACEs encompass abuse and familial dysfunction prior to the age of 18 and, in the general population, have been linked to compromised well-being and work-related challenges in adult life. An online survey was conducted to explore the prevalence of ACE categories and ACE scores (i.e., the sum of each ACE category experienced by a person) among DSPs (n = 386) working in licensed settings. Seventy-five percent of DSPs experienced at least one ACE and 30% had an ACE score of four or more. DSPs who identified as female and those who had been in their position less than one year had significantly higher ACE scores than males and others who had been in their position longer, respectively. In comparison with other studies, the four most common ACE categories among DSPs (i.e., divorce, emotional abuse, mental illness, and substance abuse) were the same, however, DSPs in the present study had a higher average ACE score and nearly twice the percentage of persons having an ACE score of four or more. The potential implications of ACEs among DSPs, at the intersection of their work with individuals with IDD, are discussed.
Content arrangement characteristic based encryption in cloud using public auditing for data management
Authors: Jerard V. Joseph Michael , Manimegalai P. 
Published: March 2018

The encryption standard related to cryptography provide the possible keys with logical standard for sharing and distributing sensitive information sharing worldview in conveyed frameworks. A Content Arrangement Characteristic Based Encryption (CA-CBE) is turning into a promising cryptographic solution for this issue. The cloud needs to provide the view on open auditability. Many methodologies have been discussed on dynamic information administration and on general auditability, however those methodologies suffer from the issue of check overhead and time multifaceted nature. Therefore, it is important to propose a Content Arrangement Characteristic Based Encryption (CA-CBE) scheme for supporting data dynamics over the data operation, like block alteration, block inset, and deletion. Some existing data integrity based research always lacks in dynamic operations and public auditability. By considering this as a motivation, this research is initiated.
A Neural Network Based Strategy (NNBS) for Automated Construction of Test Cases for Testing an Embedded System using Combinatorial Techniques
Authors: Mudarakola Lakshmi Prasad , Sastry J. K. R. 
Published: March 2018

Testing an embedded system is required to locate bugs in software, diminish risk, development, repairs costs and to improve performance for both users and the company. Embedded software testing tools are useful for catching defects during unit, integration and system testing. Embedded systems in many cases must be optimized by engaging crucial areas of the embedded systems considering all factors of the input domain. The most important concern is to build a place of test cases depend on design of the requirements that can recognize more number of faults at a least rate and point in time in the major sections of an embedded system. This paper proposes a Neural Network Based strategy (NNBS) to generate optimized test cases based on the considerations of the system. A tool called NNTCG (Neural Network Test Case Generator) has been build up based on the method proposed in this paper. Test cases are generated for testing an embedded system using NNTCG and the same are used to determine the expected output through the neural network and the output generated from the actual firmware. The faulty paths within the firmware are determined when the output generated by the neural network is not same as the output generated by the firmware.
Structural retrofitting in historic buildings – the case of Hearst Greek theatre, California
Authors: Bansal Kanika 
Published: March 2018

A modification process after manufacturing or constructing is called Retrofitting. Within the existing built forms it refers to the transitions made to the systems in the building or the structure after it is constructed or put to its defined use. Within the present day context, there are many historic buildings that are still in use or have the potential for future use. These may not be sometimes used to their full potential, despite their historic character and environmental features as most of them do not satisfy the contemporary needs of the present day user. They may also have been built for a purpose that no longer exists or has changed and often lag behind today’s performance standards and codes. Therefore, for contemporary use of such historic buildings, Retrofitting for Rehabilitation is an opportunity for alterations and additions to suit it to the present day context. The most significant aspect of retrofitting is associated with structural refurbishment which aids for added strength, stability and safety of the historic buildings. Retrofitting measures in a historical building aims to improve the overall performance of the building, facilitate techniques to alter, repair or add to make the historic building fit for contemporary use without jeopardizing their historic qualities. Through case examples, the paper aims to bring out the trends in retrofitting and the retrofitting techniques that are being adopted in contributing to a sustainable future of historic buildings. The structural retrofitting techniques adopted at the Hearst Greek Theatre, California exemplify how historic buildings can be structurally rehabilitated to become a sustainable resource for future generations.
A Study on graph with Desmos through Ict in diploma in elementary education of tamil Nadu state board
Authors: Charles Paul P. , Thulasi G. 
Published: March 2018

This paper aims at bringing out the skill based learning outcomes in teaching learning process specific to psychomotor domain through ICT’s based on New Educational Technology 2013. The present study intends to apply the Desmos software to teach the Linear Graph chapter in Diploma in Elementary Education (D.El.ED) of Second year in Tamil Nadu State. It explains the teaching strategies, i.e. visualization of graphical structure with the above module. Desmos gives hands-on experience to understand the mathematical, Graphical concepts. It also aims for an extended study on Algebra, Statistics and Geometry in the second year source book prescribed for the (D.El.ED) Course of Tamil Nadu State Board.
FEM method structural analysis of pressure hull by using hyper mesh
Authors: Balaji V. , Ravi S. , Naveen Chandran P. 
Published: March 2018

Pressure hulls are the central load bearing structures of naval submarines, and AUVs ( autonomous underwater vehicles).. A pressure hull is a structure that is designed to resist the compressive forces related with hydrostatic pressure. The most coherent geometries for resisting these compressive forces are annular cross-sections, and thus, pressure hulls are typically composed of a combination of cones and ring-stiffened cylinders, with torispherical domes or spherical at either end. These shells are subject to an external pressure of 65 Bar due to the difference between outside and inside pressure.In the current paper, 3-D Modelling are carried out as per ASME codes to endure the pressure of 65 Bar. At length to thickness ratio of the pressure hull is very large, both 3D shell and 3D solid FEA models were developed and analyzed using Ansys Simulation. The 3D modeling of the assembly has used UNIGRAPHICS software and Finite element analysis is done using ANSYS-Hyper Mesh software.
L2 cache performance analysis for MPSoC by tag – comparision
Authors: A Jenitha , R Elumalai 
Published: March 2018

Memory systems in many applications are becoming increasingly large, contributing to many challenges in the memory management that has led to many method to manage memory. The tag comparison consumes large amount of cache energy. Current methods provide tag comparison cache or failure of the expected cache. Here is proposed an idea based on new call Comparing Tag stages, filter bloom is presented to improve the efficiency of the cache to predict failure and partial tag comparison for the cold line of verification and full comparison check for direct labels. Moreover, the administration of the cache that is filled with cache lines occurs when there is a cache miss. Today's embedded applications use MPSoC. The MPSoC consists of the following ie more than one processors, shared memory among the processors available and a global off-chip memory. Planning of the activities of an integrated application processor and memory partition between processors are two main critical problem. Here, for an integrated application, both task scheduling and partitioning the integrated available L2 cache to reduce the runtime approach is used.
Vitality and peripatetic sustain cluster key management schemes in MANET
Authors: Thylashri S. , Femi D. , Alex David S. , Suresh A. 
Published: March 2018

A mobile Ad Hoc network (MANET) is aself-configuring, structure-less network of devices connected wirelessly. The disseminated nature of MANETs signifiesaunrivaledresponsibility to security architects. Key management is essential part of securitythis issue is considerably greater in MANETs. In view of dynamic nature of MANETs, when a node leaves or goes along with it have to produce new session key to hold forward and backward secrecy. Our proposed scheme focus in: 1) Cluster establishment 2) Link consistency 3) Cluster key Generation. The individual node residences are proven andthe nodes are ordered into clusters totally on their transmission series. Utilizing this, an advanced technique is invoked for the cluster head determination and cluster development. The proposedscheme saves time and vitality for common cluster updations and key updations. . To prevent the non-group memberships from deciphering the information, complicated key called Group Key is being created. The confidentiality of the Group key is being maintained. Group key evadethe issue of authentications and third partyparticipation. Recurrent updations, the chance of key hacking and replacing certificates are being decreased. The outcomes demonstrate that the throughput, existence time of the nodes, link consistency is expanded with least utilization of vitality. Our proposed scheme additionally reduces overhead, end-end delay and packet loss. The quantity of key updations is being reduced in our proposed framework and link consistency is retained.