bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Quality over quantity:” smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor
Authors: Buch Vivek P. , Purger David , Datta Anjali , Wang Allan , Barbosa Daniel , Chodakiewitz Yosefi , Lev-Tov Lior , Li Chelsea , Halpern Casey , Henderson Jaimie , McNab Jennifer A. , Bitton Rachelle R. , Ghanouni Pejman 
Published: November 2024

IntroductionMRI-guided focused ultrasound (MRgFUS) thalamotomy of the nucleus ventralis intermedius (VIM) has emerged as a powerful and safe treatment modality for refractory essential tremor. While the efficacy of this technique has been extensively described, much remains unclear about how to optimize MRgFUS for patient quality of life (QoL), which may depend as much on a patient’s adverse effect profile as on the magnitude of tremor suppression. Diffusion tensor imaging (DTI) has been used to help guide targeting strategies but can pose certain challenges for scalability.MethodsIn this study, we propose the use of a simplified patient-reported change in QoL assessment to create an unbiased representation of a patient’s perception of overall benefit. Further, we propose a large-sample-size, high-resolution, 7 T DTI database from the Human Connectome Project to create a normative tractographic atlas (NTA) with representations of ventral intermediate nucleus subregions most likely to be structurally connected to the motor cortex. The NTA network-based hotspots are then nonlinearly fitted to each patient’s T1-weighted MRI.Results and discussionWe found that smaller lesion size and higher extent to which the lesion is within the NTA hotspot predicted patients’ change in QoL at last follow-up. Though long-term change in clinical rating scale for tremor (CRST) impacted QoL, neither intraoperative tremor suppression nor the patient’s long-term perception of tremor suppression correlated with QoL. We provide an intraoperative threshold for accumulated dose volume (&lt;0.06 cc), which along with the network-based hotspot in the NTA, may facilitate an easily scalable approach to help limit treatment to small, safe yet effective lesions that optimize change in QoL after MRgFUS.
Brain functional connectivity under teleoperation latency: a fNIRS study
Authors: Ye Yang , Zhou Tianyu , Zhu Qi , Vann William , Du Jing 
Published: November 2024

IntroductionLong-distance robot teleoperation faces high latencies that pose cognitive challenges to human operators. Latency between command, execution, and feedback in teleoperation can impair performance and affect operators’ mental state. The neural underpinnings of these effects are not well understood.MethodsThis study aims to understand the cognitive impact of latency in teleoperation and the related mitigation methods, using functional Near-Infrared Spectroscopy (fNIRS) to analyze functional connectivity. A human subject experiment (n = 41) of a simulated remote robot manipulation task was performed. Three conditions were tested: no latency, with visual and haptic latency, with visual latency and no haptic latency. fNIRS and performance data were recorded and analyzed.ResultsThe presence of latency in teleoperation significantly increased functional connectivity within and between prefrontal and motor cortexes. Maintaining visual latency while providing real-time haptic feedback reduced the average functional connectivity in all cortical networks and showed a significantly different connectivity ratio within prefrontal and motor cortical networks. The performance results showed the worst performance in the all-delayed condition and best performance in no latency condition, which echoes the neural activity patterns.ConclusionThe study provides neurological evidence that latency in teleoperation increases cognitive load, anxiety, and challenges in motion planning and control. Real-time haptic feedback, however, positively influences neural pathways related to cognition, decision-making, and sensorimotor processes. This research can inform the design of ergonomic teleoperation systems that mitigate the effects of latency.
Association between sleep duration and three obesity indicators among middle-aged and elderly adults: findings from the NHANES 2005–2014
Authors: Jiang Mengjin , Shou Binyao , Shi Lihua , He Min 
Published: November 2024

ObjectiveObesity has emerged as a worldwide problem. In recent years, it has been verified that there is an association between sleep duration and obesity indicators. This provides a new approach to control obesity. In this study, the relationship between duration of sleep and body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) among Americans ≥45 years old was investigated.MethodsData was collected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2014. The link between sleep duration and obesity indicators was analysed using multiple regression models and weighted smoothed curve fitting. Subgroup analysis was conducted to assess the consistency of the connection between sleep duration and obesity indicators across various groups.ResultsThis study involved 7,118 males and 7,265 females, with an average age of 62.09. After total adjustment, sleep duration was negatively correlated with BMI (β = −0.19, 95%CI: −0.26, −0.12), WC (β = −0.36, 95%CI: −0.53, −0.19) and WHtR (β = −0.27, 95%CI: −0.38, −0.17). Subgroup analyses revealed more significant negative associations between sleep duration and BMI, WC, and WHtR among non-Hispanic White participants, and those without diabetes and hypertension.ConclusionSleep duration was significantly negatively associated with BMI, WC, and WHtR, suggesting that longer sleep duration may contribute to lower obesity indicators in middle-aged and elderly Americans. Subgroup analysis showed that their negative correlation differed between races, diabetes, or hypertension status. However, additional prospective studies are required to validate these findings and investigate potential causal relationships.
Global hotspots and trends in tea anti-obesity research: a bibliometric analysis from 2004 to 2024
Authors: Liu Shan , Fan Boyan , Li Xiaoping , Sun Guixiang 
Published: November 2024

BackgroundThe prevalence of obesity and its related ailments is on the rise, posing a substantial challenge to public health. Tea, widely enjoyed for its flavors, has shown notable potential in mitigating obesity. Yet, there remains a lack of exhaustive bibliometric studies in this domain.MethodsWe retrieved and analyzed multidimensional data concerning tea and obesity studies from January 2004 to June 2024, using the Web of Science Core Collection database. This bibliometric investigation utilized tools such as Bibliometrix, CiteSpace, and VOSviewer to gather and analyze data concerning geographical distribution, leading institutions, prolific authors, impactful journals, citation patterns, and prevalent keywords.ResultsThere has been a significant surge in publications relevant to this field within the last two decades. Notably, China, Hunan Agricultural University, and the journal Food and Function have emerged as leading contributors in terms of country, institution, and publication medium, respectively. Zhonghua Liu of Hunan Agricultural University has the distinction of most publications, whereas Joshua D. Lambert of The State University of New Jersey is the most cited author. Analyses of co-citations and frequently used keywords have identified critical focus areas within tea anti-obesity research. Current studies are primarily aimed at understanding the roles of tea components in regulating gut microbiota, boosting fat oxidation, and increasing metabolic rate. The research trajectory has progressed from preliminary mechanism studies and clinical trials to more sophisticated investigations into the mechanisms, particularly focusing on tea’s regulatory effects on gut microbiota.ConclusionThis study offers an intricate overview of the prevailing conditions, principal focus areas, and developmental trends in the research of tea’s role against obesity. It delivers a comprehensive summary and discourse on the recent progress in this field, emphasizing the study’s core findings and pivotal insights. Highlighting tea’s efficacy in obesity prevention and treatment, this study also points out the critical need for continued research in this area.
Association between copper and Achilles tendon disease: a two-sample Mendelian randomization study
Authors: Chen TianYang , Gu Yan , Zhang ZiHao , Chen ZhaoLiang , Zhang JingQuan , Leng Xiangyang 
Published: November 2024

BackgroundThere is a clear association between micronutrients and Achilles tendon disease (AT). An increase in micronutrients may alleviate AT symptoms and have a therapeutic effect. The aim of this study is to clarify the causal relationship between 15 micronutrients (copper, zinc, magnesium, vitamins A, C, E, D, B6, B12, folic acid, carotene, iron, selenium, calcium, and potassium) and AT.MethodsWe employed the Mendelian randomization (MR) method to analyze the causal effects of micronutrients on the risk of AT. The SNPs related to micronutrients were obtained from a large-scale genome-wide association study (GWAS) of circulating micronutrients in European populations. Outcome data were obtained from a meta-analysis of AT in European-ancestry participants from the Finnish FINNGEN BIOBANK. The main analysis was conducted using the inverse variance weighting (IVW) method, with additional sensitivity and pleiotropy analyses performed.ResultsInverse variance weighting results indicated a causal relationship between copper and AT (P = 0.003, OR = 0.899, 95% CI = 0.839–0.964). Sensitivity analysis validated the robustness and reliability of this finding.ConclusionThis study revealed a causal relationship between copper and AT, with copper serving as a protective factor. This provides evidence of the causality between copper and AT, offering new insights for clinical research and therapeutic approaches in AT.
Tumor seeding across specialties: a systematic review
Authors: Kipnis Pavel , Ramanathan Diya , Hoehn Richard , Jethwa Ashok R. , Karakla Daniel W. , Rohr Bethany , Sutter Christopher M. , Mark Jonathan R. , Khaja Sobia F. , Li Shawn , Thuener Jason , Carroll Bryan T. 
Published: November 2024

BackgroundUnderstanding shared characteristics underlying reported tumor seeding episodes can reveal when tumor seeding is most likely to occur and guide clinical decision making. Our goal was to systematically review tumor seeding across specialties and determine what types of instrumentation and primary tumor histology are associated with tumor seeding.MethodsA systematic review was conducted using PubMed and Web of Science, per PRISMA guidelines. Publications ranged from 1965 to 2022, and studies with five or more reports of seeding were included. Papers were sorted by specialty and assigned a PRISMA Level of Evidence, and data analysis was conducted based on whether each paper supported the clinical significance of seeding.Results7,165 papers were screened with 156 papers included for analysis. Overall, there were 8,161 cases of tumors seeding across specialties with the majority from general surgery, gastroenterology, and urology. Laparoscopy (n=1,561) and needle biopsy (n=3,448) were most frequently implicated, and carcinomas (n=5,778) and adenocarcinomas (n=1,090) were the most common primary tumor types.DiscussionUpon review of the most updated (2023) versions of the NCCN and NICE guidelines across all cancer types, there were identified gaps in the coverage of tumor seeding within these guidelines, with tumor seeding being entirely absent from certain guidelines and partially absent from others.ConclusionsGiven the high cumulative reports of seeding and the deadly and disseminated nature of secondary disease, it is important to consider seeding risk when manipulating tumors and to modify current cancer care guidelines (NCCN/NICE) to ensure that they appropriately address seeding risk.
Cannabidiol inhibits transient receptor potential canonical 4 and modulates excitability of pyramidal neurons in mPFC
Authors: Han Yujun , Wang Shuting , Xiang Yu , Chang Liuliu , Wang Xian , Ren Shimin , Guo Fei , Li Tianyu , Liu Zhiqiang , Li Yang 
Published: November 2024

Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been extensively studied for its potential therapeutic effects on various central nervous system (CNS) disorders, including epilepsy, chronic pain, Parkinson’s disease, and stress-related neuropsychiatric disorders. However, the pharmacological mechanisms of CBD have not been fully elucidated due to the complexity of their targets. In this study, we reported that the transient receptor potential canonical 4 (TRPC4) channel, a calcium-permeable, non-selective cation channel, could be inhibited by CBD. TRPC4 is highly abundant in the central nervous system and plays a critical role in regulating axonal regeneration, neurotransmitter release, and neuronal network activity. Here, we used whole-cell electrophysiology and intracellular calcium measurements to identify the inhibitory effects of CBD on TRPC4, in which CBD was found to inhibit TRPC4 channel with an IC50 value of 1.52 μM TRPC4 channels function as receptor-operated channels (ROC) and could be activated by epinephrine (EP) via G proteins. We show that CBD can inhibit EP-evoked TRPC4 current in vitro and EP-evoked neuronal excitability in the medial prefrontal cortex (mPFC). These results are consistent with the action of TRPC4-specific inhibitor Pico145, suggesting that TRPC4 works as a functional ionotropic receptor of CBD. This study identified TRPC4 as a novel target for CBD in the CNS and suggested that CBD could reduce the pyramidal neuron excitability by inhibiting TRPC4-containing channels in the mPFC.
Variation in adherence measures as a function of calculation methods
Authors: Rohay Jeffrey M. , Dunbar-Jacob Jacqueline M. 
Published: November 2024

AimWe aim to compare different operational definitions of medication adherence as well as examine the within-patient variability among these measures among patients treated for multiple comorbid conditions.MethodsElectronically monitored adherence data from a study on comorbid conditions were examined using three different calculation methods. DAILY adherence calculated the number of administrations divided by the number prescribed, without considering inter-dose interval. TIMING used predefined inter-dose intervals. Measures were aggregated to six 30-day periods. A PILLCOUNT approach counted the total administrations divided by the expected number in each 30-day period. Within-patient variability was computed based on DAILY and TIMING results for each 30-day period.ResultsResults varied by adherence calculation method. PILLCOUNT demonstrated the largest adherence rates (89%–92%); DAILY rates were lower (79%–85%); and TIMING was the lowest (62%–68%) over the 6-month period. TIMING within-patient variability (29%–35%) was larger than DAILY (20%–25%).DiscussionDifferences among the three methods confirm the importance of the adherence definition. TIMING may underestimate medicinal effects because patients may take medication as instructed (e.g., with meals) rather than at fixed intervals. PILLCOUNT may overestimate adherence by not accounting for inconsistent use. DAILY may best provide daily estimates of correct administration. Higher variability for TIMING may indicate patients are more likely to vary time between doses. Adherence calculation methods are important in interpreting results. Variability measures provide a more complete picture of adherence and may raise the likelihood of effects on biological outcomes. We propose studies of adherence include calculation method in the definition of adherence.
Enhancing cross-cultural well-being: a mixed methods study on critical thinking, cultural intelligence, and eudaimonic well-being in arts students’ cultural identity development
Authors: Peng Yue 
Published: November 2024

IntroductionThis research explores the role of critical thinking and cultural intelligence in psychological well-being through the lens of cultural identity development. It aims to understand how individuals think critically and navigate different cultural challenges that influence their psychological wellbeing.MethodsThe quantitative analysis utilizes various scales to elucidate the correlation between critical thinking beliefs, cultural intelligence, and well-being. The qualitative exploration employing NVivo 20.0 uncovers the interplay between critical thinking, cultural intelligence, and well-being in the construction of cultural identity and psychological selfhood.ResultsThe research results show a significant positive correlation between critical thinking, cultural intelligence, and psychological well-being. Themes such as well-being, cultural intelligence, critical thinking, and facing challenges illustrate how individuals navigate obstacles to achieve a meaningful and purposeful life. The findings from both the quantitative and qualitative analyses provide a comprehensive understanding of how critical thinking, cultural intelligence, and well-being intersect and influence individuals’ perceptions of themselves and their cultural identities.DiscussionThe research results suggest that developing critical thinking and cultural intelligence positively impacts individuals’ psychological well-being in cultural identity development. This can lead to greater belonging and acceptance in diverse cultural settings.
Everyone is searching for it and those who acquired it enjoy better mental health: a latent profile analysis of Chinese adolescents’ meaning in life
Authors: Zhou Xiaohua , Yu Lu , Deng Chen , Ren Yaoxiang , Du Meng 
Published: November 2024

ObjectiveOne factor associated with rising rates of depression and anxiety among youth is a lack of meaning in life (MIL). The importance of living a meaningful and purposeful life cannot be overstressed, especially for adolescents who are in a critical life stage and have recently experienced a 3-year-long global health crisis, namely the COVID-19 pandemic. Although previous studies have examined adolescents’ MIL, the majority of them adopted a variable-centered approach. The present study adopts a person-centered approach to investigate the updated MIL among Chinese adolescents in the aftermath of the COVID-19 pandemic, the demographic factors related to profile classification, and the differences in mental health among adolescents in different MIL classes.MethodsA questionnaire assessing MIL, depression, anxiety, stress, and demographic information was administered to 1,196 Chinese adolescents (mean age = 13.07 ± 0.58; 44.73% were female individuals). A three-step latent profile analysis was conducted.Results and discussionThis study revealed that (1) adolescents can be categorized into three classes: high MIL, medium MIL, and low and searching MIL. (2) Adolescents from intact families with higher educated mothers were more likely to be classified as high MIL class rather than low MIL class. Furthermore, (3) adolescents with high MIL experienced the best mental health outcomes, those with medium MIL experienced moderate mental health, and those with low MIL, who were still searching for MIL, exhibited the poorest mental health. External support may be necessary in the search process for Chinese adolescents. Future research could explore the process of searching for MIL and identify the challenges adolescents encounter when developing their sense of MIL.
Effect of match location on the playing style of teams coached by ‘Pep’ Guardiola
Authors: Pueyo Luis , Murillo Víctor , Álvarez Javier , Sarmiento Alberto , Amatria Mario 
Published: November 2024

IntroductionAnalysis in football seeks to find the performance factors that bring teams closer to success.MethodsThis study aims to analyze the playing styles of two teams managed by Pep Guardiola (F.C. Barcelona and Manchester City) based on match location (home or away). Two methods of analysis were used: descriptive statistics through chi-square tests to evaluate game characteristics and the polar coordinates technique to analyze the relationships between the different lines of each team (goalkeeper, defenders, midfielders, and forwards).ResultsThe results showed that F.C. Barcelona maintained a consistent playing style regardless of location, exhibiting significant differences only in actions that involved shots or header (p = 0.035), with better performance at home. In contrast, Manchester City displayed significantly different performance in action success (p &lt; 0.001), level of play elaboration (p = 0.004), density (p = 0.033), duration (p = 0.036), and actions that included a shot (p = 0.001) depending on the location. Additionally, qualitative analyses revealed differences in the relationships among the team lines according to match location, with Manchester City displaying more variability in these interactions than F.C. Barcelona.DiscussionThe study concludes that although Guardiola applies a consistent set of strategies, match location has a greater influence on Manchester City’s performance, suggesting that this team adjusts its playing style on the basis of contextual conditions. These findings highlight the importance of considering factors such as location when preparing tactics to increase the probability of success in elite football.
The effects of electronic cigarette use patterns on health-related symptom burden and quality of life: analysis of US prospective longitudinal cohort study data
Authors: Cao Yue , Zhang Xuxi , Fearon Ian M. , Li Jiaxuan , Chen Xi , Xiong Yuming , Zheng Fangzhen , Zhang Jianqiang , Sun Xinying , Liu Xiaona 
Published: November 2024

ObjectiveThis study aimed to examine the association between e-cigarette (EC) use patterns and health-related symptoms (fatigue, pain, and emotional problems) as well as general quality of life (QoL).MethodsData were analyzed from 7,225 adults across Waves 1–6 of the US Population Assessment of Tobacco and Health (PATH) study. Current combustible cigarette (CC) or EC use patterns included dual CC/EC use, exclusive EC use, non-current use of CC or EC, and exclusive CC smoking. Multivariate linear mixed-effects models were used to investigate longitudinal associations between EC use patterns, and symptom burdens/QoL scores.ResultsThose who were not currently smoking or vaping reported the lowest fatigue, pain, and emotional problems, and the best QoL, among the four groups (all p &lt; 0.001). Compared to exclusive CC smoking, exclusive EC use was associated with a significant decrease of 0.065 units in average fatigue (95% confidence interval [CI]: −0.121, −0.009), of 0.206 units in average pain (95% CI: −0.355, −0.058), and of 0.103 units in average QoL scores (95% CI: −0.155, −0.051), with emotional problems similar over time.ConclusionExclusive EC users had less health-related symptoms and better QoL than those who were exclusive CC smokers. This should be taken into account when assessing the harm reduction potential of ECs.