bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia
Authors: Vicioso Yorleny , Gram Hermann , Beck Rose , Asthana Abhishek , Zhang Keman , Wong Derek P. , Letterio John , Parameswaran Reshmi 
Published: May 2019

Abstract
Drug-resistant acute lymphoblastic leukemia (ALL) patients do not respond to standard chemotherapy, and an urgent need exists to develop new treatment strategies. Our study exploited the presence of B-cell activating factor receptor (BAFF-R) on the surface of drug-resistant B-ALL cells as a therapeutic target. We used anti–BAFF-R (VAY736), optimized for natural killer (NK) cell–mediated antibody-dependent cellular cytotoxicity (ADCC), to kill drug-resistant ALL cells. VAY736 antibody and NK cell treatments significantly decreased ALL disease burden and provided survival benefit in vivo. However, if the disease was advanced, the ADCC efficacy of NK cells was inhibited by microenvironmental transforming growth factor-beta (TGFβ). Inhibiting TGFβ signaling in NK cells using the TGFβ receptor 1 (R1) inhibitor (EW-7197) significantly enhanced VAY736-induced NK cell–mediated ALL killing. Our results highlight the potential of using a combination of VAY736 antibody with EW-7197 to treat advance-stage, drug-resistant B-ALL patients.
Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife
Authors: Robertson Josefina , Schaufelberger Maria , Lindgren Martin , Adiels Martin , Schiöler Linus , Torén Kjell , McMurray John , Sattar Naveed , Åberg Maria , Rosengren Annika 
Published: May 2019

Background:
Modifiable lifestyle factors in relation to risk for cardiomyopathy, a common and increasing cause of heart failure in the young, have not been widely studied. We sought to investigate a potential link between obesity, a recognized predictor of early heart failure, in adolescence and being diagnosed with cardiomyopathy in adulthood.

Methods:
This was a nationwide register-based prospective cohort study of 1 668 893 adolescent men (mean age, 18.3 years; SD, 0.7 years) who enlisted for compulsory military service from 1969 to 2005. At baseline, body mass index (BMI), blood pressure, and medical disorders were registered, along with test results for fitness and muscle strength. Cardiomyopathy diagnoses were identified from the National Hospital Register and Cause of Death Register during an up to 46-year follow-up and divided into categories: dilated, hypertrophic, alcohol/drug-induced, and other. Hazard ratios were calculated with Cox proportional hazards models.

Results:

During follow-up (median, 27 years; Q1–Q3, 19–35 years), 4477 cases of cardiomyopathy were identified, of which 2631 (59%) were dilated, 673 (15%) were hypertrophic, and 480 (11%) were alcohol/drug-induced. Increasing BMI was strongly associated with elevated risk of cardiomyopathy, especially dilated, starting at levels considered normal (BMI, 22.5–<25 kg/m
2
; hazard ratio, 1.38 [95% CI, 1.22–1.57]), adjusted for age, year, center, and baseline comorbidities, and with a >8-fold increased risk at BMI ≥35 kg/m
2
compared with BMI of 18.5 to <20 kg/m
2
. For each 1-unit increase in BMI, similarly adjusted hazard ratios were 1.15 (95% CI, 1.14–1.17) for dilated cardiomyopathy, 1.09 (95% CI, 1.06–1.12) for hypertrophic cardiomyopathy, and 1.10 (1.06–1.13) for alcohol/drug-induced cardiomyopathy.

Conclusions:
Even mildly elevated body weight in late adolescence may contribute to being diagnosed with cardiomyopathy in adulthood. The already marked importance of weight control in youth is further strengthened by these findings, as well as greater evidence for obesity as a potential important cause of adverse cardiac remodeling that is independent of clinically evident ischemic heart disease.
Are We Justified in Conducting Invasive Research on Captive Apes for Their Wild Counterparts?
Authors: Kraska Katlin 
Published: May 2019

Abstract
Wildlife species are threatened for a variety of reasons; research on captive individuals of the same species can, in some circumstances, prevent wild population decline. Such decisions pit conservationists and animal rights advocates against one another—the former are interested in survival of the species and the latter in individual rights. I argue that invasive research on captive animals for the sake of wild animals is justifiable in cases of emergency only if it is the lesser of two evils. This requires that the individual chimpanzee be compensated for harms incurred. I then argue this logic generally does not apply to human beneficiaries of invasive research conducted on chimpanzees. This is not because species membership is morally significant, but because asymmetrical power relations characterized by dependency and vulnerability will always exist between the groups if human interests are at stake. The argument focuses on federal chimpanzee conservation policy.
The Emerging Alliance of Religion and Ecology
Authors: Tucker Mary Evelyn 
Published: May 2019

AbstractThe role of the world's religions may be crucial in rethinking the relationship of humans to the natural world in a mutually enhancing manner. I first acknowledge, although briefly, the scale and complexity of the environmental crisis. Next, I suggest the need for seeking common grounds to work toward a resolution of the crisis. Then I highlight the call for the co-operation and action of the world's religions from particular sectors such as environmental groups, the United Nations, political leaders, scientists, and ethicists. Finally, I document some of the responses and the resources of the world's religions in evoking new attitudes toward nature.
Self and Nature in Heidegger
Authors: Bubbio Paolo Diego 
Published: May 2019

Abstract
This article provides an analysis of the development of the notions of “self” and “nature” through three stages of Heidegger’s thought. The main contention is that Heidegger’s conceptions of the self and nature are indissolubly connected to each other, and that such connection appears through three concerns that represent important elements of continuity: 1) the “irreducibility of the self,” conceived in a non-subjectivist way; 2) the recovery of a non-objectivist “originary” account of nature; 3) the overall commitment to the overcoming of the polarization between subject and object. I argue that there is a parallelism in the way self and nature are addressed in each of the three phases; and that the transformations of the notions are functional to the project of addressing the concerns mentioned earlier. I conclude by addressing the “violence of nature,” which remains a “blind spot” in the philosophy of the later Heidegger.
Sought Out for Luxury, Castrated for Lust: Mistress-Slave Sex in Tertullian’s Ad Uxorem 2.8.4
Authors: Flexsenhar Michael 
Published: May 2019

Abstract
While speaking to the women of his church about marriage, widowhood, and remarriage Tertullian of Carthage marshals a negative example of prosperous gentile women taking their own freedmen or slaves as their sexual partners. Common opinion is that this example was chiefly metaphorical, warning against mixed marriages between Christian women and non-Christian men. This article shows that Tertullian’s example of mistress-slave sex was a rhetorical trope also deployed in other early Christian writings that participated in a Roman literary discourse on household management (oikonomia). As such Tertullian’s example of mistress-slave sex was more than metaphorical. It sought to establish a marriage economy that regulated Christian women’s bodies for their economic resources. The example further reveals Tertullian’s economic interests in Christian marriage, tensions over gender roles and class, and a fear that some Christian women might also enter relationships with their own freedmen or slaves.
Romani Principes Adversum Nos Provocantur: Augustine of Hippo’s Epistula 87 to Emeritus of Caesarea
Authors: Dunn Geoffrey D. 
Published: May 2019

Abstract
Prior to the 411 colloquy at Carthage, Augustine had written to Emeritus, the Donatist bishop of Cherchell, urging him to abandon his adherence to Donatism. A complaint of the Donatists against the Caecilianists was that they urged the state to persecute Donatists. Augustine put words into Emeritus’ mouth: “… you stir up the Roman emperors against us.” (Ep. 87.8) Augustine told Emeritus that one can only be persecuted if one’s cause is right; if evil then it is legitimate punishment. In Augustine’s view the Donatists have brought imperial punishment (not persecution) upon themselves because of their schism. This paper will show how Augustine sidesteps a dilemma using Paul’s letter to the Romans: while it is true that Christians should not judge each other (Rom 14:4), it is the responsibility of the state to punish wrongdoers (Rom 13:2-4), while it is the responsibility of Christians to rehabilitate them (Rom 11:23).
Neilos Kabasilas’s Rule of Theology and the Distinction between the Light and Warmth of Fire in Neilos Kabasilas and Gregory Palamas
Authors: Biriukov Dmitry 
Published: May 2019

Abstract
I review the central propositions of Neilos Kabasilas's Rule of Theology and analyze the pre-history of a particular theme of vital importance for the treatise's wider theological tradition: the distinction between the warmth and light of fire (the sun) in Palamite theology. This analogy meant to clarify the distinction between the divine essence and energies, as well as between the energies themselves.
Neuf ans d’études shīʿites (2009-2017). Bilan et perspectives
Authors: Terrier Mathieu 
Published: May 2019

Abstract
This article purports to report, without claiming to be exhaustive, on the recent dynamism within Shīʿi studies and their echoes throughout the various fields of Islamology. The first part will present a brief history of Shīʿi studies and the successive biases that have affected them. The second part will retrace the course of these studies over nine years (2009-2017), focusing on three collective works that rehabilitate in different ways Henry Corbin’s analyses (m. 1979), considered outdated by some. The third part will address three areas in which recent Shīʿi studies have proved particularly fruitful: the history of early Islam; the intra-Shīʿi minorities and the origins of Islam; Islamic philosophy after Averroes (d. 1198). The sum total will reflect a decompartmentalisation of Shīʿi studies both internally, between the different currents and aspects of Shīʿism, and externally, between Shīʿism and Sunnism, philosophy or Sufism.
The Blending of Thai-Muslim Musical Performances in Southern Thailand
Authors: Sumrongthong Bussakorn 
Published: May 2019

Introduction
This paper is a research report of investigative fieldwork on the musical culture of the southern provinces of Thailand. The research was conducted by interviewing prominent musicians from each of the following provinces: Chumphon, Krabi, Nakhon Si Thammarat, Phang-Nga, Phatthalung, Phuket, Satun, Songkhla, Surat Thani and Trang. The current political instability in the provinces of Pattani, Yala and Narativas prevented conducting research in these locales.
Validation of the name Asterosiphon dichotomus (Xanthophyceae)
Authors: VISHNYAKOV VASILY S. 
Published: May 2019

Asterosiphon Dangeard (1940: 720) presents a monospecific genus of xanthophytes, which can be easily distinguished from other genera in having filamentous siphons and exclusively asexual reproduction. Asterosiphon species forms macroscopic rosette of a few millimeters in diameter consisting of green procumbent and dichotomously branched siphons which are attached to wet soil by scarcely branched colorless rhizoids. The green filaments normally form the chains of akinetes germinating into the new siphons instantly or produce numerous aplanospores. Both ways of reproduction have been thoroughly investigated by Dangeard (1940, 1942) and subsequently by Rieth (1962a, b), who established identity of Asterosiphon siphons with Gongrosira-like stage of thalli ascribed previously to some representatives of the genus Vaucheria de Candolle (1801: 20) (Stahl 1879). The published records of Asterosiphon species are very scarce and concern to a few countries of Europe (Dangeard 1942, Rieth 1962b, Christensen 1986, Langangen 1994, Kusel-Fetzmann 1999, Cambra-Sánchez 2010, Carter & John 2012), Algeria (Gauthier-Lièvre 1954), India (Gupta 2012), China (Liu et al. 1994), and Argentina (Lacoste de Díaz 1981, cit. ex Cambra-Sánchez 2010).
Prevailing Surface Wind Direction during Air–Sea Heat Exchange
Authors: Ogawa Fumiaki , Spengler Thomas 
Published: May 2019

AbstractWhile the climatological-mean sensible and latent heat fluxes are remarkably well described using climatological-mean fields in the bulk flux formulas, this study shows that a significant fraction of the climatological-mean wind speed in the midlatitudes is associated with wind variations on synoptic time scales. Hence, the prevailing wind direction associated with the most intense air–sea heat exchange can differ from the mean wind direction. To pinpoint these striking differences between the climatological and synoptic viewpoint, this study presents a global climatology of the prevailing surface wind direction during air–sea heat exchanges calculated for instantaneous and time-averaged reanalysis data. The interpretation of the fluxes in the lower latitudes is basically unaffected by the different time averages, highlighting the time-mean nature of the circulation in the lower latitudes. In the midlatitudes, however, the prevailing wind direction features a significant equatorward component for subweekly time averages and reverts to pure westerlies for longer time averages. These findings pinpoint the necessity to consider subweekly time scales, in particular along the midlatitude SST fronts, to describe the air–sea heat exchange in a physically consistent way.
Boundary Layer Turbulence over Surface Waves in a Strongly Forced Condition: LES and Observation
Authors: Husain Nyla T. , Hara Tetsu , Buckley Marc P. , Yousefi Kianoosh , Veron Fabrice , Sullivan Peter P. 
Published: May 2019

AbstractThe impact of sea state on air–sea momentum flux (or wind stress) is a poorly understood component of wind–wave interactions, particularly in high wind conditions. The wind stress and mean wind profile over the ocean are influenced by the characteristics of boundary layer turbulence over surface waves, which are strongly modulated by transient airflow separation events; however, the features controlling their occurrence and intensity are not well known. A large-eddy simulation (LES) for wind over a sinusoidal wave train is employed to reproduce laboratory observations of phase-averaged airflow over waves in strongly forced conditions. The LES and observation both use a wave-following coordinate system with a decomposition of wind velocity into mean, wave-coherent, and turbulent fluctuation components. The LES results of the mean wind profile and structure of wave-induced and turbulent stress components agree reasonably well with observations. Both LES and observation show enhanced turbulent stress and mean wind shear at the height of the wave crest, signifying the impact of intermittent airflow separation events. Disparities exist particularly near the crest, suggesting that airflow separation and sheltering are affected by the nonlinearity and unsteadiness of laboratory waves. Our results also suggest that the intensity of airflow separation is most sensitive to wave steepness and the surface roughness parameterization near the crest. These results clarify how the characteristics of finite-amplitude waves can control the airflow dynamics, which may substantially influence the mean wind profile, equivalent surface roughness, and drag coefficient.
Assessing the concurrent validity of a gait analysis system integrated into a smart walker in older adults with gait impairments
Authors: Werner Christian , Chalvatzaki Georgia , Papageorgiou Xanthi S , Tzafestas Costas S , Bauer Jürgen M , Hauer Klaus 
Published: May 2019

Objective: To assess the concurrent validity of a smart walker–integrated gait analysis system with the GAITRite® system for measuring spatiotemporal gait parameters in potential users of the smart walker. Design: Criterion standard validation study. Setting: Research laboratory in a geriatric hospital. Participants: Twenty-five older adults (⩾65 years) with gait impairments (habitual rollator use and/or gait speed <0.6 m/s) and no severe cognitive impairment (Mini-Mental State Examination ⩾17). Main measures: Stride, swing and stance time; stride length; and gait speed were simultaneously recorded using the smart walker–integrated gait analysis system and the GAITRite system while participants walked along a 7.8-m walkway with the smart walker. Concurrent criterion-related validity was assessed using the Bland–Altman method, percentage errors (acceptable if <30%), and intraclass correlation coefficients for consistency (ICC3,1) and absolute agreement (ICC2,1). Results: Bias for stride, swing and stance time ranged from −0.04 to 0.04 seconds, with acceptable percentage errors (8.7%–23.0%). Stride length and gait speed showed higher bias (meanbias (SD) = 0.20 (0.11) m; 0.19 (0.13) m/s) and not acceptable percentage errors (31.3%–42.3%). Limits of agreement were considerably narrower for temporal than for spatial-related gait parameters. All gait parameters showed good-to-excellent consistency (ICC3,1 = 0.72–0.97). Absolute agreement was good-to-excellent for temporal (ICC2,1 = 0.72–0.97) but only poor-to-fair for spatial-related gait parameters (ICC2,1 = 0.37–0.52). Conclusion: The smart walker–integrated gait analysis system has good concurrent validity with the GAITRite system for measuring temporal but not spatial-related gait parameters in potential end-users of the smart walker. Stride length and gait speed can be measured with good consistency, but with only limited absolute accuracy.
Characteristics and analysis of right-to-left shunt-related dizziness in patients without hypoxemia
Authors: Cao Liming 
Published: May 2019

Objective This study aimed to analyze right-to-left shunt-related dizziness in three patients without hypoxemia. Methods Case 1 was a 47-year-old man with a history of cerebral infarction 8 years previously and recurrent dizziness for > 6 months. Patent foramen ovale (PFO) was found with a severe right-to-left shunt. Case 2 was a 50-year-old man with acute stroke. He had a history of repeated dizziness for > 4 years. He was diagnosed with PFO with a severe right-to-left shunt after admission. Case 3 was a 73-year-old woman with recurrent dizziness for > 10 months. Pulmonary arteriovenous fistula was diagnosed upon admission. No patients had hypoxemia. Results After percutaneous PFO occlusion in Cases 1 and 2, the patients were followed up for 6 months and 1 year, respectively. Two patients had relief of dizziness without recurrence. In Case 3, the pallor improved and the dizziness was relieved after pulmonary arteriovenous fistula embolization and did not recur over a 6-month follow-up. Conclusions There was a possible association between a severe right-to-left shunt and dizziness, although hypoxemia was absent in the cases. Intervention to eliminate a left-to-right shunt can improve dizziness in patients without hypoxemia with a severe right-to-left shunt.
Gaps in Understanding of the Epidemiology of Mood and Anxiety Disorders among Migrant Groups in Canada: A Systematic Review
Authors: Edwards Jordan , Hu Malini , Thind Amardeep , Stranges Saverio , Chiu Maria , Anderson Kelly K. 
Published: May 2019

Objective: Estimates of mood and anxiety disorders are highly variable among migrant groups, as they are influenced by the socio-political context. Our objective was to conduct a systematic review and meta-analysis to synthesize available Canadian evidence on the prevalence and incidence of mood and anxiety disorders among migrant groups. Methods: Studies were identified from MEDLINE, EMBASE, and PsycINFO. They were included if they used population-based samples, presented data on the incidence or prevalence of diagnosed or self-reported mood or anxiety disorders for first-generation migrant groups in Canada, and used a Canadian-born or long-term resident reference group. Results: Nineteen studies met our inclusion criteria. Prevalence ratios ranged from 0.48 to 0.87, and nearly all estimates were obtained from population health surveys. Prevalence estimates among migrant groups were lower than the reference group, with the 90th percentile of estimates ranging from 1.5% to 8.2%. Risk factors for mood and anxiety disorders among migrants included being female, younger, unemployed, having lower income, and living in neighborhoods with a lower proportion of migrants. Conclusions: There remain many gaps in our current understanding of mood and anxiety disorders among migrant groups in Canada. Although evidence suggests the prevalence of mood and anxiety disorders are consistently lower among migrant groups, a lack of incidence estimates limits the strength of this conclusion. Future research should focus on comparisons of self-reported and diagnosed estimates, the use of a range of different primary or secondary data sources, and consideration of important risk factors. Prospero Citation: Jordan Edwards, Malini Hu, Amardeep Thind, Saverio Stranges, Maria Chiu, Kelly Anderson. The burden of mood and anxiety disorders among immigrant and refugee populations in Canada: a systematic review. PROSPERO 2018 CRD42018087869 Available from: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018087869 .
How to Teach Evidence-Based Practice in Social Work: A Systematic Review
Authors: Spensberger Florian , Kollar Ingo , Gambrill Eileen , Ghanem Christian , Pankofer Sabine 
Published: May 2019

Purpose: This article presents a systematic review of research regarding how best to educate social work students and practitioners concerning of the process of evidence-based practice and/or the application of empirically supported treatments (ESTs). Method: We conducted a systematic review with a narrative synthesis, largely following the Cochrane Handbook of Systematic Reviews for Interventions and PRISMA reporting guidelines for systematic reviews and meta-analyses. Results: Twenty-seven studies met our eligibility criteria. These consisted mostly of uncontrolled designs and their measures relied mainly on learners’ self-perception regarding acquisition of declarative and procedural knowledge, motivation, and satisfaction. Reports were mostly positive (88.7%). Conclusions: Research regarding the education of social work students and practitioners about the process of evidence-based practice as well as ESTs is limited. Further investigation is needed concerning the effectiveness of specific teaching methods using controlled designs and more rigorous outcome measures including observation of practice in real-life situations and/or in role-plays.