bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Total Hip Arthroplasty to a Patient Associated with Alcoholic Cirrhosis and Severe Plated Deficiency with Preoperative Partial Splenic Embolization
Authors: Yamanaka Yasuhiro , Nakano Hiroaki , Nakayama Hiroshi , Okumura Junichiro 
Published: November 2018

Introduction:
We present the first report of the successful treatment of Total Hip Arthroplasty (THA) to a patient associated with alcoholic cirrhosis and plated deficiency undergoing preoperative Partial Splenic Embolization.

Case Report:
A 45-year woman who had Liver Cirrhosis (LC) and alcohol residue heritage failure suffered from severe groin pain and had a difficulty in walking for a long period due to avascular necrosis of bilateral femoral head. She was referred to our orthopaedic service and THA was planned. Despite preoperative transfusion for her platelet deficiency coursed by LC, preoperative platelet count decreased less than a normal range. Therefore, Partial Splenic Embolization (PSE) was applied to her so as to increase platelet count. PSE could temporally reduce the portal vein pressure and prevent a hyperspleism and cytopenia. After the procedure, THA was performed to bilateral hip safely through a direct anterior approach. At the time of the latest follow-up, the patient had an excellent clinical result.

Conclusion:
Preoperative PSE may be a useful procedure to the patients with LC and severe plated deficiency who need arthroplasty including THA. Pre-existing physical and psychological factors have an effect on the outcome of arthroplasty and appropriate strategies might be needed.
Developing mobile learning as ecology practical tool using three-layer observation framework
Authors: Sambodo Rizki Agung , Prayitno Baskoro Adi , Karyanto Puguh , Sulistyowati Eka 
Published: November 2018

Developing a practical tool in ecology that addresses the challenge of transferring the ecologicalconcept systematically has become an essential factor in achieving a better understanding of the teaching process. Three-layer Observation Framework (TlOF) is one of the best methods that can be adopted in designing practical work in ecology since its power in providing a step-by-step concept reconstruction. This research aimed to develop a sample of practical work in ecological teaching and learning based on the TlOF. This research followed the ADDIE method in developing the product with some modifications. The research focus was set to gain product’s appropriateness from validators and users. The developed product was tested in Biology Education Department at the State Islamic University of Sunan Kalijaga, Yogyakarta in order to collect responses for further product improvement. The results of the appropriateness test from three validators showed that the developed product is “very good” with an average score of 81.8. During the performed preliminary test by users, as high as 82.5 was achieved. It means that the developed product gained a good perception from the respondents. According to the results, TlOF-based mobile learning the practical tool is the potential to become an alternative media in improving practical work in term of encompassing ecological concepts.
QUALITATIVE AND QUANTITATIVE ANALYSIS OF LEAVES AND STEM OF TINOSPORA CORDIFOLIA IN DIFFERENT SOLVENT EXTRACT
Authors: Garg Praveen , Garg Rajesh 
Published: November 2018

Tinospora cordifolia is known as Giloe and Guduchi, with significant importance in the traditional medicinal systems. It is dioeciously plant. It is mostly used in Ayurved system. It is also known as a ‘Rasayans’ of medicinal system, which develops immune system of the body and protect against infection. The aim of this study is carried out to analyse the phytochemical compounds in leaves and stem extracts of T. cordifolia by using phytochemical screening tests and estimate total flavonoid content (TFC) by using aluminium chloride method in the sample extracts. The leaf and stem extracts of T. cordifolia expressed the presence of several phytochemicals viz., flavonoids, amino acids, diterpines, protein, saponins and carbohydrates. The result of phytochemical screening tests revealed that diterpines and carbohydrates are positive in all extracts of T. cordifolia, but flavonoids and saponins only present in methanol and ethanol extracts. TFC of T. cordifolia was higher in ethanolic leaves extracts than mathanolic leaves extracts. The studies justify that T. cordifolia use in traditional medicines. The investigation further proposed that the phytochemicals present in stems and leaves of T. cordifolia, which can be use as natural antioxidants in medicinal drugs.
Keywords: Tinospora cordifolia, Phytochemicals, Flavonoids
COMPARISON OF RP-HPLC AND UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF HALOPERIDOL IN PURE AND PHARMACEUTICAL FORMULATION
Authors: Jain AK , Dubey BK , Basedia D , Dhakar S , Ahirwar M , Jain P 
Published: November 2018

An accurate, precise, sensitive and reproducible High-performance liquid chromatographic (HPLC) and UV spectrophotometric methods were developed and validated for the quantitative determination of haloperidol (HPD) in bulk drug and pharmaceutical formulation. Different analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization ICH Q2B guidelines. The RP-HPLC method was developed by the isocratic technique on a reversed-phase Thermo C18 (250 × 4.6 mm, 5µm) column with mobile phase consisting of Methanol: Acetonitrile (50:50v/v) at flow rate of 1.0 ml/min. The retention time for HPD was 2.238±0.3min. The UV spectrophotometric determinations were performed at 244 nm using 80% methanol as a solvent. The linearity range for HPD was 5-25 μg/ml for both HPLC and UV method. The linearity of the calibration curves for each analyte in the desired concentration range was good (r2 >0.999) by both the HPLC and UV methods. The method showed good reproducibility and recovery with percent relative standard deviation less than 2%. Moreover, the accuracy and precision obtained with HPLC co-related well with the UV method which implied that UV spectroscopy can be a cheap, reliable and less time consuming alternative for chromatographic analysis. The proposed methods are highly sensitive, precise and accurate and hence successfully applied for determining the assay and in vitro dissolution of a marketed formulation.
Keywords: HPLC, UV Spectrophotometry, Haloperidol, Pharmaceutical formulation, Method validation, Quantitative analysis
Study on Fish Fauna Diversity of Bhusara maun under Muzaaffarpur district of Bihar
Authors: Kumari Nishi , Pathak Ravindra Nath 
Published: November 2018

The present study has been carried from Bhusara maun under Muzaaffarpur district of Bihar”. Fish diversity on this lentic water body has been studied in detail with its food value and commercial status. Twenty eight Fish species of fishes were recorded, which belonged to 20 genera and 14 families. A classified list of fishes has been given. The Indian major carps and few fresh species are commercially important groups in the Bhusara maun
Keywords: Fish species, diversity, food value. Commercially important.
Study on the Diversity and seasonal variation of zooplankton in Bhusara maun under Muzaffarpur, Bihar
Authors: Kumari Nishi , Pathak Ravindra Nath 
Published: November 2018

Diversity of zooplankton in the Bhusara maun was studied during March 2010- Feb 2011. The population of zooplankton consisted of rotifers copepods and cladocerans. Total number of zooplankton recorded were 2335 per litre of which rotifers were 1461 (62.56%), cladocerans 226 (9.67%) and copepods 608 (27.75%). All the dominant groups of zooplankton present throughout the year. Diversity analysis showed that rotifers had 11 species cladoccrans four and copepode four species. High number of zooplankton were recorded in winter season. While low number was recorded in monsoon season.
Keyword: Zooplankton, Bimodal distribution, Diversity richness
THERAPEUTIC MICROEMULSION OF CURCUMIN FOR THE MANAGEMENT OF OSTEOARTHRITIS
Authors: Sharma Shreyasi , Ganju Eisha , Upmanyu Neeraj , Jain Prabhat 
Published: November 2018

Curcumin (diferuloylmethane) is a natural polyphenolic compound with potent anti-inflammatory, anticancer and antioxidant activities. However, its bioavailability is low as it is poorly absorbed in the gastrointestinal tract. Microemulsions offer the potential to improve the solubility and bioavailability of bioactive compounds; the present work investigated the topical delivery potential of microemulsion gel loaded with curcumas. Curcumin microemulsion was prepared by spontaneous emul­sification method using oil (Oleic acid), surfactant:cosurfactant (Smix) (Ethanol and Tween 80, Span 80 and n Butanol) and water. The optimized formulations of microemulsions were subjected to thermodynamic stability tests. After stability study, stable formulation was characterized for droplet size, pH determination, centrifugation, % drug content in microemulsion, zeta potential and vesicle size measurement and then microemulsion gel were prepared and characterized for spreadability, measurement of viscosity, drug content, In-vitro diffusion, in-vitro release data. Tween 80, Span 80 was selected as surfactant, ethanol, n Butanol as co surfactant and Oleic acid as oil component based on solubility study. The optimized formulation contained Curcumin (10 mg). The in vitro drug release from curcumin microemulsion gel was found to be considerably higher in comparison to that of the pure drug. The in-vitro diffusion of microemulsion gel was significantly good. Based on this study, it can be concluded the solubility and permeability of curcumin can be increased by formulating into microemulsion gel.
Keyword: Curcumin, Microemulsion, In-vitro diffusion, Spreadability, Zeta potential, Stability, span 40
Potential Drug-Drug Interactionsamong Adult Patients Admitted to MedicalWards at a Tertiary Teaching Hospital inEthiopia
Authors: Kibrom Samson , Tilahun Zelalem , Huluka Solomon Assefa 
Published: November 2018

Abstract
Introduction: A Drug-drug interaction (DDI) is a decrease or increase in the pharmacological or clinical response to the administration of two or more drugs that are different from the anticipated response they initiate when individually administered.
Objectives: To assess the prevalence and factors associated with potential DDIs among adult inpatients admitted to the medical wards of a tertiary teaching Hospital in Ethiopia.
Methods: A retrospective cross-sectional study design was employed on adult patients who were admitted to the medical ward in one year period. A total of 384patients’ medical records were checked for a possible DDI using Micromedex DrugReax® drug interaction database and analyzed consecutively using SPSS version 20.0.
Results: Among 384 adult patients enrolled in the study, 209 (54.4%) of them had medications with at least one potential DDI in their prescriptions. Of the 209 potential DDI, 26.3% were with a minimum of one major potential DDI. The median number of potential DDI per patient was 2.2. Overall, 296 potential DDI were identified in the current study. Among 296 identified potential drug-drug interactions, most of the interaction (49.7%) had good documentation. The number of medication prescribed per patient showed a significant (p< 0.001) association with the occurrence of potential DDIs.
Conclusion: More than half of the patients’ prescription contains potentially interacting medications. This study, additionally, revealed that there is a significant association between potential DDIs and number of medications prescribed per patient.
Key words: Drug-drug interactions, pharmacokinetic interaction, pharmacodynamic interaction, internal medicine
“The Winter Oak”: Inspiring Passion for Teaching
Authors: Allen Robert D. 
Published: November 2018

ABSTRACT
The purpose of this article is to inspire those who desire to improve their teaching effectiveness. A short story, “The Winter Oak” (Nagibin 1953), provides an organizing framework to articulate some of the most important factors involved in effective and influential teaching. Surrounding each of four parts of the story, I summarize research on the attributes of effective educators, discuss real-life, challenging situations and their outcomes, comment on lessons learned from “The Winter Oak,” and include stories of inspiring educators. These elements provide opportunities for reflection about the wonders of teaching and learning.
Social and Psychosocial Determinants of Health Associated With Uncontrolled Diabetes in a Federally Qualified Health Center Population
Authors: Rivich Julianna , Kosirog Emily R. , Billups Sarah J. , Petrie Jennifer L. , Saseen Joseph J. 
Published: November 2018

Purpose.
Many people with diabetes have difficulty achieving glycemic targets, and social and psychosocial determinants of health may influence their ability to obtain glycemic goals. The objective of this study was to identify characteristics independently associated with A1C &gt;9% or untested A1C compared to those with A1C ≤9% at a federally qualified health center.

Methods.
This retrospective cohort study included people with a diagnosis of diabetes, who were 18–89 years of age and had a medical evaluation from a primary care provider between 1 September 2016 and 31 August 2017. The primary outcome was to identify characteristics associated with an A1C &gt;9% or untested A1C compared to those with an A1C ≤9%.

Results.
Of 6,185 patients meeting inclusion criteria, 2,965 (48%) had uncontrolled A1C. In the uncontrolled A1C group, 1,549 patients (52%) were female, 1,296 (44%) preferred care in a language other than English (1,273 [43%] in Spanish), and 535 (18%) had a concurrent mental health diagnosis. Multivariable logistic regression of 4,774 patients with complete data revealed that poor appointment adherence (odds ratio [OR] 3.24, 95% CI 2.30–4.57) and/or a positive Patient Health Questionnaire-2 depression screen (OR 1.35, 95% CI 1.12–1.62) had an increased risk of being in the uncontrolled A1C group. Patients with a prescription for antidepressant medication were more likely to be in the controlled group.

Conclusion.
Poor adherence to appointments and presence of depressive symptoms were associated with high A1C values. Interventions can be developed targeting these determinants to improve blood glucose levels.
Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage
Authors: A. Hamid Zainab , J. Ali Solaf , Hattem Hussain Ali 
Published: November 2018

Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes. CD14 was implicated in immune mechanisms, and might be involved in pregnancy loss. The aim of this study was to detect the possible occurrence of two HSV-1 and HSV-2 infections as well as the immunological factor cd14 in placental tissues from patients with spontaneous abortion using immunohistochemistry techniques. Immunohistochemistry technique assay was used to detect placental infection with HSV-1& HSV-2 as well as CD14 in 40 women with spontaneous miscarriage and in 40 healthy deliveries in Baghdad/Iraq. The IHC- expressions of HSV-1, HSV-2, and CD14 proteins were detected in 4(10%), 15(37.5%), 15(37.5%) in placental tissues from miscarriage women, respectively. The association between CD14 with HSV-1 and HSV-2 among the placental tissues from miscarriage patients was constituting (5%), (20%) with HSV-1 & HSV-2, respectively. The considerable proportion of HSV-1, HSV-2, and infections found in the placental tissues from miscarriage women could drag the attention of obstetricians to implicate these viruses as possible targets in the etiology of spontaneous abortion case and there is possible association of CD14 with HSV-1 and HSV-2 in women with abortion.
Dyslipidemia among Patients with End Stage Renal Disease on Maintenance Hemodialysis
Authors: Ghazi Abdulhadi Mohammed , Omer Mohammed Mohammed , Bakir Maarouf Fenk 
Published: November 2018

Dyslipidemia has been suggested to be one of the factors that contribute to the high incidence of cardiovascular disease in hemodialysis patients. Previous studies suggest that end-stage renal disease may contribute to dyslipidemia. The aim of the study: to assess the prevalence of dyslipidemia in patients on maintenance hemodialysis. Patients and Methods: A case-control study was conducted from February 2015 until August 2015 in Ibn-Sena teaching hospital on 100 participants (52 males and 48 females), 50 were patients with end-stage renal disease on regular hemodialysis and 50 were age and gender-matched apparently healthy subjects as the control. Questioner used to collect data, a thorough examination was done including height and weight and BMI. A blood sample from all participants in fasting state was sent for the renal function test, complete blood picture, serum albumin, electrolytes, TG, total cholesterol, LDL and HDL measured by the enzymatic method, plasma atherogenic index calculated as [log (TG/HDL)]. Results: Age of the participants ranged between 18 - 70 years and the mean age was (44.45 ± 13.6) years. In HD group, the mean cholesterol was (3.29 + 0.73) mmol/l, serum TG (2.38 ± 0.56) mmol/l, LDL (1.91 ± 0.66) mmol/l, HDL (0.88 ± 0.2) mmol/l, atherogenic index (0.434 ± 0.16), while in control group, the mean cholesterol was (4.17 ± 0.69) mmol/l, serum TG (1.6 ± 0.43) mmol/l, LDL (2.69 ± 0.63 ) mmol/l, HDL (1.066 ± 0.13) mmol/l, atherogenic index (0.177 ± 0.12). The lipid abnormalities in hemodialysis group were high plasma atherogenic index in 84%, hypertriglyceridemia 50%, hypercholesterolemia 8% and high LDL 6% and low HDL in 48%, while in control group, high plasma atherogenic index in 34%, hypertriglyceridemia in 26%, hypercholesterolemia 14% high LDL 7% and low HDL in 16%. Conclusions: patients with end-stage renal disease on hemodialysis have significant dyslipidemia compared to control group characterized by hypertriglyceridemia, low HDL and high atherogenic index of plasma.
Rancang Bangun Sistem Manajemen Budidaya Ayam Broiler Berbasis Web Menggunakan Metode Prototyping
Authors: Fani Ridho Hawali , Surya Ibnu , Adin Saf Maksum Ro'is 
Published: November 2018

Beternak dengan sistem kemitraan merupakan suatu bentuk usaha yang sedang marak saat ini, beternak secara kemitraan merupakan bentuk kerja sama antara peternak dengan perusahaan. Hasil panen akan dibagi sesuai persenan yang telah disepakati pada Memorandum of Understanding (MoU). Dibutuhkan waktu lebih kurang 4-6 minggu bagi peternak untuk memelihara ayam hingga panen. Selama periode tersebut, peternak harus merawat ayam dengan maksimal sehingga diharapkan hasil panen menguntungkan bagi peternak dan perusahaan tersebut. Maka dari itu, sistem ini dibangun agar dapat mengatasi permasalahan seperti pemberian pakan atau vaksin yang tidak teratur, pencatatan perkembangan ayam tiap hari yang masih dilakukan secara manual, penanganan penyakit dan kurangnya wawasan terhadap penyakit yang sering didapatkan oleh ayam, serta penghitungan timbangan yang masih dilakukan secara manual. Sehingga dengan mengatasi permasalahan tersebut hasil panen menjadi meningkat dan tingkat produktifitas ayam menjadi terkendali. Tools yang digunakan dalam pembuatan sistem ini adalah Visual Studio 2017. Setelah dilakukan pengujian selama tiga periode ternak, sebanyak 82.6% responden dari sepuluh orang yang merupakan peternak ayam broiler menyatakan sistem tersebut dapat meningkatkan efisiensi dalam beternak ayam broiler.
Sistem Pengawasan Keuangan Badan Usaha Milik Desa (BUM Des) berbasis Android
Authors: Farokhah Lia , Sapoetra Yudistira Arya 
Published: November 2018

Program pemerintah untuk peningkatan potensi desa dalam bentuk badan usaha milik desa (BUM Des) sedang digalakkan dengan serius. Pemerintah menganggap ini adalah salah satu cara mengentaskan kemiskinan dengan cara peningkatkan kesejahteraan dan memandirikan desa secara keuangan. Namun, ada banyak masalah yang ada di lapangan seperti kekurang percayaan pengurus internal BUM Des sendiri terhadap kelembagaan BUM Des. Hal ini menyebabkan banyak desa yang ragu dalam mendirikan BUM Des atau BUM Des yang sudah berdiri namun tidak berkembang. Masalah transparansi merupakan masalah yang paling utama dalam kelembagaan BUM Des. Sistem kepercayaan, pengelolaan dan transparansi keuangan serta pembagian hasil hasil usaha yang menjadi pokok tujuan hampir setiap BUM Des yaitu kesejahteraan. Dalam perancangan aplikasi pengawasan keuangan BUM Des mendapatkan hasil umpan balik sebesar sebesar 82,77%. Hal ini menunjukkan hasil umpan balik yang dianggap sangat positif.
Aplikasi Informasi Harga Kebutuhan Pokok Masyarakat Real Time
Authors: Hernawati Elis , Rosely Ely , Handini Rosa Wulan 
Published: November 2018

Dalam rangka mewujudkan visi kabupaten Bandung untuk meningkatkan penyampaian informasi kinerja pemerintah melalui media diseminasi informasi sesuai Standar Pelayanan Minimal (SPM) Bidang Kominfo dan meningkatkan ketersediaan data dan informasi statistik yang berkualitas, penelitian ini membangun sebuah aplikasi berbasis web yang dapat menyajikan informasi harga kebutuhan pokok masyarakat secara realtime di Kabupaten Bandung. Aplikasi dibangun untuk membantu petugas diskominfo kabupaten Bandung ketika akan menginformasikan daftar harga kebutuhan bahan pokok secara uptodate. Selain itu aplikasi dapat membantu masyarakat ketika mencari informasi mengenai harga kebutuhan pokok di Kabupaten Bandung sehingga tidak perlu mendatangi kantor diskominfo. Metode yang digunakan dalam penelitian ini adalah metode waterfall. Metode ini digunakan karena proses dilakukan secara bertahap dan berurutan dari mulai analisis hingga pengujian aplikasi sehingga kualitas aplikasi yang dihasilkan akan baik. Implementasi pembuatan aplikasi menggunakan Framework Codeigniter, dengan bahasa pemograman PHP, serta software pengolah databasenya MySQL. Metode pengujian software menggunakan black box testing. Dengan adanya aplikasi ini masyarakat dapat mengetahui informasi harga kebutuhan pokok dengan mudah dan uptodate.
Tutoría Académica Universitaria: Percepción de estudiantes de la Facultad de Odontología. Universidad Nacional de Asunción
Authors: Benítez Stela Mary 
Published: November 2018

La tutoría universitaria es un factor de calidad y una exigencia del Espacio Europeo de Educación Superior. Forma parte del sistema de gestión de calidad de la educación. Es un acompañamiento personalizado, desde el inicio de la vida universitaria, como apoyo para el desarrollo de actitudes personales y profesionales. Ayuda a la formación crítica, responsable y participativa del discente en la sociedad, favoreciendo el aprendizaje de valores y actitudes sin dejar de lado conocimientos y habilidades. En el 2011, se creó en la Facultad de Odontología de la Universidad Nacional de Asunción, dicho Programa como una estrategia, enfocada a la formación integral del estudiante. Su objetivo fue elevar la calidad del proceso educativo, brindando atención personalizada, con miras a identificar problemas que influyen en el desempeño social y académico. Se realizó una investigación, descriptiva de corte trasversal, con enfoque cuantitativo. El objetivo fue determinar la percepción de los estudiantes, sobre el programa. Participaron 73 estudiantes, de primer al tercer curso, voluntariamente. Se aplicó un cuestionario cerrado, autoadministrado. Resultados, solo 46,6% de los tutorados refirió satisfacción respecto al programa de tutoría. El nivel de empatía del tutor fue buena (59%). La disposición de los tutores fue bueno (62,8%) y la percepción en cuanto a la capacidad tutorial fue deficiente (< 50%). Aspectos que denotan que se tiene que mejorar muchos aspectos en los tutores, como una mayor capacitación para asumir su rol.