bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Authors: McDonald Malcolm F. , Curry Rachel Naomi , O’Reilly Isabella , Lozzi Brittney , Cervantes Alexis , Lee Zhung-Fu , Rosenbaum Anna , He Peihao , Mohila Carrie , Harmanci Arif O. , Serin Harmanci Akdes , Deneen Benjamin , Rao Ganesh 
Published: November 2024

Abstract
Malignant glioma, the most lethal form of brain cancer, presents with an immunosuppressive microenvironment that obstructs tumor cell clearance and hampers immunotherapeutic interventions. Despite advancements in characterizing cellular and extracellular profiles in cancer, the immunosuppressive mechanisms specific to glioma remain poorly understood. We conducted single-cell RNA sequencing of glioma samples, which revealed a select subset of human and mouse glioma cells that express CD83, a marker associated with mature antigen-presenting cells. To investigate the impact of tumor cell CD83 expression on glioma outcomes, we used an immunocompetent mouse model of glioma, bioinformatic analyses of human samples, and in vitro assays. Our findings revealed that CD83+ tumor cells contribute to tumor growth suppression and are associated with enhanced cytotoxic T-cell profiles and activated CD8+ T cells. Increased proinflammatory cytokines were identified in CD83-overexpressing tumor conditions, which were also correlated with long-term CD8+ antitumor responses. Importantly, tumor-derived CD83 could mediate communication with T cells, altering the immune microenvironment to potentially enhance immune-related tumor clearance. Collectively, our data suggest that tumor cell expression of CD83 supports the endogenous antitumor T-cell constituency in malignant glioma. Future research endeavors may aim to further investigate whether CD83 expression can enhance immunotherapeutic approaches and improve patient outcomes.

Significance:
Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor–immune communications.
Critique of European Christianity and Modernity in the Writings of Sanaullah Makti Tangal, a 19th Century Islamic Scholar from Kerala
Authors: Ilias M.H. 
Published: November 2024

Abstract
This article explores Christian-Muslim debate in 19th-century South India through the writings of the reformist Islamic scholar Sanaullah Makti Tangal (1847–1912). Tangal spent most of his time critiquing the blurred boundaries of Western conceptions of religion, modernity, and secularism, in ways not unlike much later scholars such as Talal Asad and Saba Mahmoud. The distinctiveness of Tangal’s approach was the construction of an alternative Islamic modernity that could take the place of Western Christian norms. Modernity, in Tangal’s eyes, was not a token of rationalism or secularism, but a tool for purifying Islam in Kerala from unwanted elements adopted from local cultures. This article also places Tangal’s thought against the backdrop of the theological and philosophical debate introduced to Kerala by the colonial administration between scholars who endorsed or rejected the European reconstruction of religion.
How Acculturation Shapes Sleep in Thai Women in the United States During Menopausal Transition: A Mediation and Moderation Analysis
Authors: Srimoragot Manassawee , Reutrakul Sirimon , Hershberger Patricia E. , Park Chang , Quinn Lauretta , Liese Kylea Laina , Balserak Bilgay Izci 
Published: November 2024

Introduction: This study examines acculturation’s impact on sleep quality, efficiency, and obstructive sleep apnea (OSA) risk among Thai women in the United States transitioning through menopause. Methodology: This cross-sectional descriptive study recruited 120 Thai women aged 40 to 65. Questionnaires assessed sleep quality (Pittsburgh Sleep Quality Index [PSQI]), OSA risk (Berlin), menopausal symptoms (Menopause Rating), acculturation (Suinn-Lew Asian Self-Identity Scale), and anxiety (Patient-Reported Outcome Measurement Information System). Data were analyzed using bivariate correlations, multivariable regression, and mediation/moderation analyses. Results: Mean age was 51.53 ( SD = 7.73) years. Most were good sleepers (PSQI <5: 80.83%) and 14.17% at high risk of OSA. Acculturation was associated with better sleep quality ( B = −1.086, p = .027) and higher sleep efficiency ( B = 2.425, p = .021). Mediation analysis indicated that length of stay in the United States indirectly affected sleep quality ( B = −0.022, p = .026) and efficiency ( B = 0.051, p = .018) via acculturation. Discussion: Acculturation significantly affects sleep among Thai women; higher acculturation correlates with better sleep quality and efficiency. Acculturation did not affect OSA risk, suggesting context-specific influences that may benefit sleep through increased social integration. Future research should explore underlying mechanisms in immigrant populations.
Utilizing Theoretical Domains Framework to Determine Barriers to Evidence-Based Recommendations in Non-Valvular Atrial Fibrillation
Authors: White Evan , Kane-Gill Sandra L. , Jain Sandeep , Medico Charles , Ansani Nicole , Coons James C. 
Published: November 2024

Background: Implementation of evidence-based guidelines in patient care is inefficient. Only 14% of new research are routinely adopted into clinical practice. The atrial fibrillation (AF) practice guidelines recommend anticoagulation in men with a CHA2DS2-VASc score greater than or equal to 2 and in women with a CHA2DS2-VASc score greater than or equal to 3. Despite these recommendations, oral anticoagulation prescribing rates were found to be as low as 51%. Existing frameworks, such as the Theoretical Domain Framework (TDF), are used in implementation science to identify behavior changes to overcome barriers to guideline adoption. Objective: In this project, we explored behavioral themes and barriers that prevented clinician adherence to evidence-based recommendations for patients with non-valvular atrial fibrillation (NVAF) and developed interventions to overcome those barriers. Methods: Nine focused interviews were conducted with stakeholders across multiple disciplines involved with NVAF care. Interview questions were based on the TDF and designed to determine behavior changes necessary to increase appropriate anticoagulation prescribing and decrease unnecessary NVAF hospital admissions. The interviews were transcribed and coded using NVivo 12 qualitative data analysis software (released 2018). Themes were documented, and interventions were then developed to address the barriers. Results: TDF interviews yielded 4 main barrier themes regarding appropriate NVAF management in 2 theoretical domains. These themes were lack of knowledge, cost of anticoagulation, patient refusal to take anticoagulation, and social determinants of health. The theoretical domains were knowledge and environmental context and resources. Conclusion and Relevance: Based on our limited interviews, the TDF framework informed potential barriers contributing to the underutilization of appropriate anticoagulation in patients with NVAF. Techniques for behavior change interventions may be applied to overcome the identified barriers.
Management of late postoperative capsular bag distension syndrome – two year case series
Authors: Otrošinová Marianna , Novák Jan , Krásnik Vladimír 
Published: November 2024

Introduction Late capsular bag distension syndrome (CBS) is a rare complication of the ^lcataract surgery. Aim The aim is to present 9 cases with delayed presentation and describe their successful management with surgical approach. Method A two-year retrospective review of 9 cases was undertaken. Anterior segment optical coherence tomography (AS-OCT) was used to confirm this diagnosis. Aspiration of the milky fluid with 26 gauge needle followed by capsular bag lavage was performed and aspirated fluid was examined. Results Patients showed signs of late CBS 6,56 ± 1,94 years after uncomplicated phacoemulsification with intraocular lens (IOL) implantation into the capsular bag. All 9 patients presented with a turbid fluid collection within the distended capsular bag. AS-OCT showed a hyper-reflective material in the space between the IOL and distended posterior capsule. Conclusion Awareness of the manifestations of CBS and choice of the correct imaging modality may lead to regular diagnosis and successful treatment. Management with aspiration of the milky fluid and lavage of the capsular bag is technically safe and effective procedure. It has the advantage of microbial testing of the fluid. AS-OCT is useful tool to differentiate this condition clearly from IOL opacification and posterior capsule opacification.
Juxta-anastomotic stenosis in the forearm native arteriovenous fistula: Open surgery or angioplasty?
Authors: Dominijanni Sara , Sfara Germana , Tatangelo Paola , Cancellieri Roberto , Spinelli Alessio , Centi Alessia , Mariani Ilaria , Ammirati Luigi Maria , Marrone Giulia , Mudoni Anna , Noce Annalisa , Palumbo Roberto 
Published: November 2024

Background: The juxta-anastomotic stenosis (JAS) represents the major complication of arteriovenous fistula (AVF) during the first months after the surgery and the approach to JAS can be surgical or radiological. Methods: From 01/02/2016 to 31/12/2020, a total of 976 radiocephalic fistulas have been performed. The 15.9% of AVF was malfunctioned due to JAS. A retrospective analysis was conducted on 156 patients with JAS, in order to compare the primary outcome of surgery and percutaneous angioplasty (PTA) in JAS treatment, in the lower forearm in a follow-up of 24 months. Results: Ninety patients underwent to surgery and 66 to PTA, mean age was 63.43 ± 14.54 and 65.10 ± 15.10 years, respectively. Frequencies of diabetes mellitus and arterial hypertension were similar by groups. Cardiovascular disease was present in 20% of the surgery patients and in 42.4% PTA patients ( p = 0.04). The primary assisted patency was 84.4% and 71.1% in the surgery group at 12 and 24 months and 54.5% and 69.6% in the PTA group. The secondary patency at 24 months was 95.6% for surgery group and 96.9% for PTA group, without a statistical significance. During the study period, 10 AVFs (11.1%) showed a restenosis in the surgical group and 14 (21.2%) in the PTA group. Conclusions: This retrospective study suggests a higher restenosis rate after PTA than surgery. However, the statistical analysis shows that the failure rate of the two procedures is comparable. A dedicated multidisciplinary team could represent the goal for a good clinical practice in the treatment of JAS.
Cardiac Amyloidosis Versus Other Restrictive Cardiomyopathies: A Retrospective Analysis of Cardiovascular Outcomes and Arrhythmic Burden
Authors: Sagalov Andrew , Ullah Waqas , Brailovsky Yevgeniy , Buhnerkempe Michael , Scaife Steve , Kulkarni Abhishek , Labedi Mohamed , Hegde Shruti 
Published: November 2024

Background: The arrhythmic burden and cardiovascular risks of cardiac amyloidosis compared with other types of restrictive cardiomyopathies (RCM), such as hemochromatosis and cardiac sarcoid, have not been well characterized in the literature. An increase in emphasis on screening has resulted in more diagnoses of cardiac amyloidosis and a larger data pool to analyze the cardiovascular outcomes of this cardiomyopathy. Methods and results: We queried the National Inpatient Sample (NIS) database to identify all adult patients diagnosed with cardiac amyloidosis or other RCM between the years 2016 and 2019. Discharge-weighted analysis using survey regressions accounts for discharge weights and characteristics found to be significantly different between groups. A total sample size of 13 345 patients was obtained, including cardiac amyloidosis (N = 8365; 62.7%) and other RCM (N = 4980; 37.3%). Cardiac amyloidosis was associated with a significantly increased risk of stroke (Odds ratio = 3.91: 95% confidence interval = [2.15, 7.11], P < .001) and ventricular tachycardia (1.98 [1.35-2.91], P < .001). Cardiac amyloidosis had a decreased risk of atrial fibrillation (0.56 [0.47-0.68], P < .001). Significant differences in risk were not observed among the different types of heart block and supraventricular arrhythmias. In-hospital mortality was similar between the 2 groups ( P = .72). Conclusions: Cardiac amyloidosis was associated with an increased risk of stroke and ventricular tachycardia compared to other types of RCM. Significant differences in in-hospital mortality, bundle branch blocks, and supraventricular arrhythmias were not appreciated. A subgroup analysis comparing light chain (AL) and wild-type transthyretin (ATTR) amyloidosis outcomes would further delineate the cardiovascular risks of cardiac amyloidosis.
Efficacy, safety, and prognostic factors of capecitabine plus temozolomide regimen in patients with atypical thymic carcinoids
Authors: Liu Man , Yan Xu , Lin Xiaoxuan , Chen Luohai , Wang Yu , Luo Yanji , Lin Yuan , He Qiao , Chen Jie , Zhang Ning 
Published: November 2024

Background and objectives: Atypical thymic carcinoids (ATCs) are rare mediastinal malignancies that lack established treatment guidelines. Capecitabine and temozolomide (CapTem) has demonstrated significant efficacy in pancreatic neuroendocrine neoplasms (NENs), while its applicability and effectiveness in ATCs remain underexplored. This study seeks to investigate the efficacy, safety, and prognostic factors associated with CapTem in ATC patients. Design and methods: Thirty-eight ATC patients treated with CapTem at our center were analyzed. We assessed the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse effects. We also examined patients’ clinicopathological characteristics and their correlations with CapTem efficacy. Results: The cohort achieved a 15.8% ORR and 89.5% DCR, with a median PFS of 13.0 months. Multivariate analysis identified the platelet-to-lymphocyte ratio (PLR) as a significant independent prognostic factor for PFS, with a PLR ⩾ 235 associated with shorter PFS (7 months vs. undefined, p = 0.0004). Age was an independent prognostic factor for OS, with patients over 50 years experiencing shorter OS (36 months vs. undefined, p = 0.015). Safety analysis showed rare severe toxicities and no treatment-related fatalities. Conclusion: CapTem is an effective and well-tolerated treatment for ATC patients. Pretreatment PLR and age appear to be potential prognostic markers for CapTem therapy; however, these results warrant validation in larger patient cohorts.
Anterior Cruciate Ligament Reconstruction With The Rectus Femoris Autograft – Results From The First 80 Patients
Authors: Rego MCF , Rego MCF , Mameri ES , Barroso BG , Helito CP , Franciozi CES 
Published: November 2024

Objectives To report on the clinical outcomes and complications following anterior cruciate ligament (ACL) reconstruction using a novel rectus femoris autograft, including its clinical efficacy and safety. Methods Retrospective case series of patients undergoing isolated primary anatomic ACL reconstruction, with an outside-in technique, using a novel a rectus femoris autograft. Non-inclusion criteria consisted of partial tears; prior ipsilateral knee surgery; concomitant ligament, meniscus or cartilage procedures; follow-up shorter than 6 months. The primary clinical outcome measure was Lysholm score, including the percentage of patients achieving a previously published patient acceptable symptom state (PASS). Secondary outcomes included the observed rates for complications, as well as graft failure rate. Results 80 patients (53% male; mean age 28.95 ± 8,04 years) were included, with a mean follow up of 18.03 months (± 6,94; min 6, max 28). The mean postoperative Lysholm was 97.08 (± 2.63; min 90, max 100), with 100% of patients achieving PASS. There were three instances of graft amputation during harvest (3/83 = 3.61%), all of which occurred within the first 10 cases. An overall post-operative complication rate of 6.25% was observed, with 4 instances of hematoma at the graft harvest site (4/80 = 5%), one infection (1/80 = 1.25%) and no instances of graft failure (0/80 = 0%) at final follow-up. Conclusion The rectus femoris autograft is a suitable graft option for ACL reconstruction, with demonstrated clinical efficacy and safety in this initial case series. Potential benefits include a minimally invasive harvest technique without the need for additional instruments, and an observed length of around 30cm, which can be tailored to multiligament or revision cases. Longer follow-up and comparative studies are needed in the future in order to assess the long-term efficacy and failure rates.
Biomechanical Evaluation of Ultra-High-Strength Suture Wire Versus Thinner Tape in Vertical Inside-Out Meniscal Suture
Authors: Faria JLR , Araujo IF , Santos APG , More ADO , Salim R , Roesler CRM 
Published: November 2024

Objectives Meniscal injuries are common and can significantly affect the function of the knee joint. Surgical repair is often necessary, with meniscal preservation being preferable to meniscectomy. This study aimed to compare the biomechanical properties of ultra-high-strength suture wire and thinner tape used in vertical inside-out meniscal suture. Methods Twenty-eight porcine knees were selected for this controlled biomechanical evaluation in a laboratory setting. The knees were divided into two groups: Group S (vertical inside-out meniscal sutures using ultra-high molecular weight polyethylene [UHMWPE] suture wire) and Group T (vertical inside-out meniscal sutures using UHMWPE tape). A 1.5 cm longitudinal lesion was created in the lateral meniscus, followed by two vertical sutures on the femoral surface of the meniscus. Biomechanical analyses were performed using a testing machine, including cyclic loading tests and load-to-failure tests. Results The results showed no significant difference in lesion widening after cyclic testing or in load-to-failure between the two groups. However, the system stiffness at the 5th and 30th cycle was significantly higher in Group T compared to Group S. The system stiffness at maximum load-to-failure did not differ significantly between the groups. These findings suggest similar biomechanical behavior of the two materials under radial loads. Conclusion Thinner tapes used in meniscal suture showed biomechanical outcomes comparable to ultra-high-strength suture wires, making them attractive options for meniscal repair due to their reduced thickness, which may result in less cartilage abrasion. Further research and clinical studies are necessary to validate these results.
Is a Pre-Operative MRI Anterolateral Ligament Injury Related to Anterior Cruciate Ligament Reconstruction Failure? A Prospective Cohort Study with Minimum 5 Year Follow Up
Authors: Helito CP , Sobrado MF , Silva AGM , Pécora JR , Gobbi RG 
Published: November 2024

Objectives To evaluate the clinical outcomes and failure rate of ACL reconstruction in patients with and without ALL injury diagnosed by magnetic resonance imaging (MRI) at a minimum five year follow up Methods A prospective cohort of patients with acute ACL injury was divided into 2 groups based on the presence (ALL injury group) or absence (Control group) of ALL injury on preoperative MRI. Both groups underwent reconstruction of the ACL with autologous hamstrings grafts. The Lysholm and subjective International Knee Documentation Committee (IKDC) scores, KT-1000 and pivot shift tests, reconstruction failure rate, incidence of contralateral ACL injury, presence of associated meniscal injury and presence of knee hyperextension were evaluated. Results A total of 156 patients were evaluated. No significant preoperative differences were found between the groups. In the postoperative evaluation, patients in the control group had a lower reconstruction failure rate (14.3% vs 4.6%; P = .049) and better clinical outcomes according to the Lysholm scores (85.0 ± 10.3 vs 92.3 ± 6.3; P < .0001). Although the pivot shift was similar, KT-1000 revealed worse results for the ALL injury group (2.8 +/- 1.4 mm) compared to the control group (1.9 +/- 1.3 mm) (p = 0.00018). Patients in the ALL injury group also presented a worsening of the knee instability from two to five years according to the KT-1000 (2.4 +/- 1.6 vs 2.8 +/- 1.4; p=0.038). Conclusion Combined ACL and ALL injuries were associated with significantly less favorable outcomes than were isolated ACL injuries at a minimum follow-up of 5 years after ACL reconstruction. Patients with concomitant ALL injury showed a higher rerupture rate and worse functional scores. Also, knee stability tends to worsen from 2 to 5 years in cases of associated ALL injury.
Outcomes of cruciate ligament reconstruction on patients with associated anterolateral injury
Authors: Guerreiro JPF , Rosa LB , Gonçalves EL , Curcio ARR , Bignardi PR , Daniel MV 
Published: November 2024

Objectives Evaluate if there is a significant difference in isolated reconstruction of the ACL in patients with or without pre-operative associated injury of the ALL. Methods Transversal retrospective study by patient’s files analysis and LYNSHOLM and IKDC questionaries to patients with isolated reconstruction of the ACL. Results The 52 patients were separated in 2 groups: 19 with associated ALL injury and 33 without associated injury. None of the patients with associated ALL injury suffered new ACL tear, but 21,1% had injured other structures, while 6,1% of patients without associated ALL injury suffered new ACL tear and 18,2% injured another structure (p=0,544). The return to activities at the same preoperative level was observed in 60% with associated ALL injury and 72% without associated injury (p=0,309). The LYSHOLM score demonstrated a median of 81,1 points with associated ALL injury and 90,1 without associated injury, and the IKDC, 70,3 points with associated injury and 76,7% without associated injury (p=0,112). Conclusion No significant statistic difference was observed for graft injury or new lesions in other structures, satisfaction with the injured knee or subjective IKDC score. Return to activities was similar in both groups with or without associated ALL injury and the LYSHOLM subjective score demonstrated better results with significant statistical difference in the group without LAL associated injury.