bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Azacytidine on the Quality of Life of Patients With Myelodysplastic Syndrome Treated in a Randomized Phase III Trial: A Cancer and Leukemia Group B Study
Authors: Kornblith Alice B. , Herndon James E. , Silverman Lewis R. , Demakos Erin P. , Odchimar-Reissig Rosalie , Holland James F. , Powell Bayard L. , DeCastro Carlos , Ellerton John , Larson Richard A. , Schiffer Charles A. , Holland Jimmie C. 
Published: July 2002

PURPOSE: The impact of azacytidine (Aza C) on the quality of life of 191 patients with myelodysplastic syndrome was assessed in a phase III Cancer and Leukemia Group B trial (9221). PATIENTS AND METHODS: One hundred ninety-one patients (mean age, 67.5 years; 69% male) were randomized to receive either Aza C (75 mg/m2 subcutaneous for 7 days every 4 weeks) or supportive care, with supportive care patients crossing over to Aza C upon disease progression. Quality of life was assessed by centrally conducted telephone interviews at baseline and days 50, 106, and 182. Overall quality of life, psychological state, and social functioning were assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 and the Mental Health Inventory (MHI). RESULTS: Patients on the Aza C arm experienced significantly greater improvement in fatigue (EORTC, P = .001), dyspnea (EORTC, P = .0014), physical functioning (EORTC, P = .0002), positive affect (MHI, P = .0077), and psychological distress (MHI, P = .015) over the course of the study period than those in the supportive care arm. Particularly striking were improvements in fatigue and psychological state (MHI) in patients treated with Aza C compared with those receiving supportive care for patients who remained on study through at least day 106, corresponding to four cycles of Aza C. Significant differences between the two groups in quality of life were maintained even after controlling for the number of RBC transfusions. CONCLUSION: Improved quality of life for patients treated with Aza C coupled with significantly greater treatment response and delayed time to transformation to acute myeloid leukemia or death compared with patients on supportive care (P < .001) establishes Aza C as an important treatment option for myelodysplastic syndrome.
High-Dose Chemotherapy in the Treatment of Relapsed Osteosarcoma: An Italian Sarcoma Group Study
Authors: Fagioli F. , Aglietta M. , Tienghi A. , Ferrari S. , Brach del Prever A. , Vassallo E. , Palmero A. , Biasin E. , Bacci G. , Picci P. , Madon E. 
Published: July 2002

PURPOSE: To study the feasibility and activity of two courses of high-dose chemotherapy (HDCT) in patients with osteosarcoma in metastatic relapse. PATIENTS AND METHODS: Patients with high-grade osteosarcoma in metastatic relapse (multiple metastases or solitary metastasis at intervals of less than 30 months) were eligible for study. High-dose chemotherapy consisted of carboplatin and etoposide followed by stem-cell rescue. A second course was planned 4 to 6 weeks after the first. Surgery was performed before or after HDCT. RESULTS: Thirty-two patients were enrolled onto the study. At the end of the treatment, 25 patients were in complete remission (CR), six were alive with disease progression, and one died of toxicity. At present, 14 patients are alive with a median survival time of 23 months from study entry: four are in first CR, three are in second CR, and one is in fourth CR. Six patients are alive with disease. Eighteen patients (56%) died: 17 of disease and one of toxicity. Transplantation-related mortality was 3.1%. The relapse or progression disease rate was 84.4%. The 3-year overall survival rate is 20% and the 3-year disease-free survival rate is 12%. CONCLUSION: HDCT combined with surgery is feasible and can induce CR in a large portion of patients. Two points, however, need to be considered: only patients who are chemosensitive to induction treatment can obtain CR after HDCT, and the length of remission is short, because most patients relapse. Thus novel strategies are needed to maintain the remission status or to treat patients who do not respond to induction treatment.
Beyond Eyeball Tests: A Methodical Rebuttal to Fillon et al.'s Commentary
Authors: Adam‐Troian Jais , Bélanger Jocelyn 
Published: November 2024

ABSTRACTIn our original study, “Consumed by Creed” (Adam‐Troian & Bélanger, 2024), we established significant and consistent associations between obsessive‐compulsive disorder symptom severity and radical intentions across four distinct U.S. population samples—Environmentalists, Republicans, Democrats, and Muslims—partially or fully mediated by obsessive passion. Fillon et al. (2024) challenged our findings, alleging methodological errors and an excessive degree of researcher flexibility, which they claim could lead to false‐positive results. In this response, we critically examine Fillon et al.'s commentary, arguing that it exemplifies flawed meta‐scientific critique. We demonstrate that their approach relies on a series of unsupported and misleading claims, including a misinterpretation of the literature, unjustified reliance on visual data inspection, speculative assumptions about religious influences on our findings, and a shifting of the burden of proof. Through rigorous re‐analyses, we reaffirm the robustness of our original results and address the unfounded allegations regarding our methodological practices. We also critique Fillon et al.'s approach, highlighting the necessity of domain‐specific expertize in meta‐scientific evaluations and cautioning against the risks of speculative and defamatory criticism in academic discourse. This exchange underscores the importance of maintaining rigorous standards in both original research and its critique, ensuring that scientific debate remains grounded in evidence rather than conjecture.
Infantile Krabbe disease (0–12 months), progression, and recommended endpoints for clinical trials
Authors: Greco Melissa R. , Lopez Mabel A. , Beltran‐Quintero Maria L. , Tuc Bengur Ecenur , Poe Michele D. , Escolar Maria L. 
Published: November 2024

AbstractObjectiveKrabbe disease is due to deficiency of galactocerebrosidase, resulting in progressive neurodegeneration due to demyelination. The purpose of this study is to document disease progression in the newly classified infantile‐onset (0–12 months). We evaluated the outcomes of hematopoietic stem cell transplantation (HSCT) and described meaningful clinical endpoints.MethodsPatients with infantile Krabbe disease were prospectively evaluated between 2000 and 2022. All patients underwent comprehensive and standardized protocols. Descriptive statistics and Kaplan–Meier survival curves were used for analysis.ResultsOne hundred and thirty‐seven children with infantile Krabbe disease were included (68 males and 69 females). Of the 137, 96 were not treated and 41 underwent hematopoietic stem cell transplantation. Twenty‐three were asymptomatic and 18 symptomatic. Initial symptoms included irritability, developmental delay or loss of milestones, feeding difficulties, spasticity, and reflux with an average survival of 2.2. Abnormalities in nerve conduction studies, auditory brainstem responses, and brain MRIs were evident in both groups of patients. Age at transplantation and signs and symptoms determined functional outcomes. Symptomatic and asymptomatic transplanted patients showed an increase in galactocerebrosidase and a decrease in psychosine, but did not reach the normal range. The median survival for transplanted symptomatic patients was 5 years while asymptomatic was extended to 15.5 years.InterpretationInfantile Krabbe disease with onset before 12 months is rapidly progressive. Irreversible brain damage occurs unless timely HSCT is performed. HSCT does not prevent the progression of peripheral nerve disease. This study can be used to monitor patients and evaluate the effects of future therapies.
In Situ Gel Polymer Electrolyte with Rapid Li+ Transport Channels and Anchored Anion Sites for High‐Current‐Density Lithium‐Ion Batteries
Authors: Miao Xunzhi , Hong Jianhe , Huang Shuo , Huang Can , Liu Yushi , Liu Min , Zhang Quanquan , Jin Hongyun 
Published: November 2024

AbstractIn situ formed gel polymer electrolytes (GPEs) have advantages in safety and adaptability to current high‐voltage lithium‐ion batteries (LIBs). However, it is challenging for GPEs to achieve stable cycling at high current densities. A flexible framework is proposed for stable in situ GPE, by introducing ─CF3 groups to the polymer network to establish rapid Li+ transport channels, and incorporating secondary amine N─H groups to anchor anion. The obtained GPE exhibits a high ionic conductivity of 2.6 mS cm−1 and a high Li+ transference number of 0.67. The assembled Li||NCM811 cell demonstrates excellent rate performance, with a discharging capacity of 112.3 mAh g⁻¹ at 10C, and capacity retention of 87.6% after 260 cycles at 1C. Furthermore, the assembled graphite||NCM811 cell demonstrates excellent long‐term cycling stability with impressive capacity retention of 73.2% after 300 cycles 3C (1.8 mA cm−2). This work presents a promising approach to enhancing the cycling stability of GPEs for high‐voltage LIBs at high current density.
Surface‐Interface Engineering of Electrocatalysts for Two‐Electron Water Oxidation Reaction to Produce H2O2
Authors: Chen Zhen , Liu Xi , Wang Kun , Yang Lin , Wang Yi , Wang Xin , Song Shuqin , Chen Zhongwei 
Published: November 2024

AbstractElectrochemical two‐electron water oxidation reaction (2e− WOR) driven by renewable energy offers an attractive route to produce H2O2, while the corresponding electrocatalyst still requires further improvement for the activity, selectivity, and the resulting H2O2 yield. Surface‐interface engineering of electrocatalysts has great potential to advance 2e− WOR performance. This review provides a succinct yet comprehensive insight into the functional mechanisms of surface‐interfacial properties affecting 2e− WOR performance on electrocatalyst. The Gibbs free energy theoretical framework related to surface electronic structure and interfacial reactive kinetics mechanism related to electrolyte, electrode–electrolyte interface structure, and interfacial microenvironment properties are firstly discussed. Afterward, various surface‐interface engineering strategies toward high performance electrocatalysts including the regulation of surface electronic structure, the electrode–electrolyte interface structure, and the interfacial microenvironment have been overviewed. Rational manipulations of the above surface‐interfacial engineering strategies are critical to design highly efficient 2e− WOR electrocatalysts, leading to the development of the green H2O2 production.
Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma Photoimmunotherapy
Authors: Li Gaowei , Jiang Shichao , Zhang Zongliang , Liu Xiaoyin , Wu Kai , Liu Peng , Yang Mei , Zhou Ting , Xiao Jiamei , Xin Nini , Wu Xiaoyang , Chen Zhihong , Ding Jie , Wu Chengheng , Wei Dan , Sun Jing , Tong Aiping , Fan Hongsong , Zhou Liangxue 
Published: November 2024

AbstractGlioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options. Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success is hindered by inadequate T cell infiltration and activation due to the acidic and immunosuppressive microenvironment. Photothermal immunotherapy lyses tumors and activates immune responses, complementing BiTEs. This study innovatively employs a donor engineering strategy to develop hemicyanine dyes (Hcys) that emit from near‐infrared (NIR) I to NIR II. The Hcy with excellent properties is encapsulated in an amphiphilic micelle, forming a nano assembly with lactate oxidase (PLH1100). PLH1100 exhibits spectral absorption at 980 nm, a photothermal conversion efficiency of 58.7%, and capability for NIR‐II tumor imaging. Besides photothermal tumor ablation, PLH1100 regulates lactic acid metabolism and activates immunogenic cell death, improving the tumor microenvironment and promoting T cell infiltration and activation. Further studies demonstrate PLH1100 effectively kills human and murine GBM cells, inhibits orthotopic U87 tumor growth in BALB/c‐nu mice, and enhances the efficacy of Fn14‐targeted BiTE in orthotopic GL261 tumors in C57BL/6 mice, achieving a synergistic “1+1>2” therapeutic effect. Collectively, this work opens a new pathway for using Hcy‐based molecules combined with BiTE drugs for GBM therapy, with significant clinical potential.
PCN‐134(Fe)‐Gated Organic Photoelectrochemical Transistor with Unique Dual‐Directional Signaling
Authors: Wang Zhen , Shi Xiao‐Mei , Hu Jin , Chen Feng‐Zao , Fan Gao‐Chao , Lin Peng , Zhao Wei‐Wei 
Published: November 2024

AbstractRecently, increasing attention has been paid to exploring the unique characteristics of newly emerged organic photoelectrochemical transistors (OPECT) for biological application and neuromorphic engineering due to their effectiveness for light‐driven ionic regulation of channels interfaced with rich biochemical reactions. The observation of interesting signaling reversion is reported—the realization of dual‐directional signaling with enhanced signal resolution—enabled by porous coordination networks (PCN)‐134(Fe) in the presence of varying H2O2 concentrations, which is totally different from exiting unidirectional signaling in OPECT. The underlying mechanism of such behavior is attributed to the change in the polarity of the gate photocurrent and is explained from the perspective of potential distribution. The practical application of this device is then studied by detecting the phorbol myristate acetate (PMA)‐induced secretion of H2O2 from three kinds of human breast cells. This study features the realization of dual‐directional signaling, which is expected to catalyze a new category of OPECT operation with unknown possibilities.
Enhanced Stability of N‐Type Organic Electrochemical Transistors Via Small‐Molecule Passivation
Authors: Baek Jisu , Oh Jong Gyu , Lee Kyumin , Kim Doyeon , Lee Dongwoon , Kim Sang Beom , Jang Jaeyoung 
Published: November 2024

AbstractOrganic electrochemical transistors (OECTs) are of great interest owing to their potential applications in bioelectronics and neuromorphic systems. However, n‐type OECTs suffer from poor stability and facile degradation, mainly due to the oxygen reduction reactions in organic mixed ionic‐electronic conductors during device operation. In this study, a small‐molecule passivation strategy is introduced to greatly improve the stability of poly(benzobisimidazobenzophenanthroline) (BBL)‐based n‐type OECTs. 6,6‐Phenyl‐C61‐butyric acid methyl ester (PCBM) is spin‐coated onto the BBL layer to form a smooth and hydrophobic passivation layer, which effectively inhibits the oxygen reduction reactions while enabling ion permeation in aqueous electrolytes. Consequently, the OECTs employing the PCBM/BBL bilayers with an optimized PCBM thickness exhibit significantly improved operational stability at various electrolyte conditions (0.1 m NaCl or NaOH) and over a wide gate‐voltage sweep range (from −0.7 to 0.7 V). Owing to the high electron mobility of PCBM, the carrier mobility and switching speed of the PCBM/BBL OECTs are also improved compared with those of the pristine BBL OECTs. This study demonstrates the beneficial effects of simple surface passivation in organic mixed ionic‐electronic conductors and provides valuable insights for the design of high‐performance and stable OECTs for more specialized and advanced applications.
Electronic Coupling Between Perovskite Nanocrystal and Fullerene Modulates Hot Carrier Capture
Authors: Li Yusheng , Jiang Junke , Wang Dandan , Liu Dong , Yajima Shota , Li Hua , Fuchimoto Akihito , Li Hongshi , Shi Guozheng , Hayase Shuzi , Tao Shuxia , Shi Jiangjian , Meng Qingbo , Ding Chao , Shen Qing 
Published: November 2024

AbstractThe efficient harnessing of hot carriers holds transformative potential for next‐generation optoelectronic devices. Halide perovskites, with their remarkably long carrier lifetimes exceeding 10 picoseconds, stand at the forefront of this research frontier. Yet, a fundamental paradox persists: why does efficient hot carrier capture remain elusive despite these extended lifetimes? Here, this conundrum is unraveled by constructing a donor–acceptor model system: perovskite nanocrystal and fullerene hybrids. It is demonstrated that the challenge lies not only in the carrier lifetime itself but in the nature of the coupling between donor and acceptor components. Remarkably, it is discovered that the formation of ground‐state complexes, with effective coupling across a wide energy range, not only overcomes the initially forbidden hot carrier capture within these hybrids but also dramatically enhances it, achieving a ≈76% hot carrier capture efficiency. This finding shifts the paradigm of hot carrier capture from extending carrier lifetimes to engineering donor–acceptor coupling, illuminating a path toward practical hot carrier applications.
Unraveling the Synergy of Au and Polar MgO(111) Surface in Photothermal Catalytic Oxidative Coupling of Methane
Authors: Shen Tianyang , Hu Siyu , Sun Xiaoliang , Liu Guihao , Song Ziheng , Wu Zhaohui , Zheng Lirong , Song Yu‐Fei 
Published: November 2024

AbstractDirect and selective catalytic oxidative coupling of methane (OCM) into high‐carbon products is a great challenge in C1 chemistry. Herein, the successful fabrication of a series of Au clusters loaded on different MgO facets of (111), (110), and (100) is reported. This work demonstrates the Au‐loaded MgO(111) (denoted as Au/MgO(111)) shows the highest C2H6 yield of 12733.4 µmol g−1 h−1 and selectivity of 90.4%, which is 2.46 times higher than that of Au/MgO(110) (5171.4 µmol g−1 h−1) and 25.14 times higher than that of Au/MgO(100) (506.4 µmol g−1 h−1). Moreover, the high activity of Au/MgO(111) can be well maintained over 100 h. Detailed in situ experiments and theoretical calculation reveal such great performance can be attributed to 1) the strong electronic affinity of the surface oxygen species on polar MgO(111) and CH4with the lowest adsorption energy of −0.82 eV; 2) the Au/MgO(111) shows the lowest ΔERDS of 0.53 eV in the rate‐deterime step of OCM that comes in activating the second CH4 molecule; 3) the Au can act as a hole acceptor under light irradiation and adsorb *CH3 with a strong d‐σ hybridization, resulting in an increased C2H6 selectivity.
Foreign Body Immune Response to Zwitterionic and Hyaluronic Acid Granular Hydrogels Made with Mechanical Fragmentation
Authors: Asadikorayem Maryam , Weber Patrick , Surman František , Puiggalí‐Jou Anna , Zenobi‐Wong Marcy 
Published: November 2024

AbstractGranular hydrogels have recently attracted the attention for diverse tissue engineering applications due to their versatility and modularity. Despite previous studies showing enhanced viability and metabolism of cells encapsulated in these hydrogels, the in vitro immune response and long‐term fibrotic response of these scaffolds have not been well characterized. Here, bulk and granular hydrogels are studied based on synthetic zwitterionic (ZI) and natural polysaccharide hyaluronic acid (HA) made with mechanical fragmentation. In vitro, immunomodulatory studies show an increased stimulatory effect of HA granular hydrogels compared to bulk, while both bulk and granular ZI hydrogels do not induce an inflammatory response. Subcutaneous implantation in mice shows that both ZI and HA granular hydrogels resulted in less collagen capsule deposition around implants compared to bulk HA hydrogels 10 weeks after implantation. Moreover, the HA granular hydrogels are infiltrated by host cells, including macrophages and mature blood vessels, in a porosity‐dependent manner. However, a large number of cells, including multinucleated giant cells as well as blood vessels, surround bulk and granular ZI hydrogels and are not able to infiltrate. Overall, this study provides new insights on the long‐term stability and fibrotic response of granular hydrogels, paving the way for future studies and applications.
Engineering Injectable and Highly Interconnected Porous Silk Fibroin Microspheres for Tissue Regeneration
Authors: Ding Ji , Cheng Zhaojun , Ma Yulong , Zhang Tongxing , Du Lilong , Jiang Xiaobing , Zhu Meifeng , Li Wen , Xu Baoshan 
Published: November 2024

AbstractInjectable porous microspheres represent a promising therapeutic platform for cell delivery, drug delivery, and tissue regeneration. Yet, the engineering of silk fibroin microspheres with a highly interconnected porous structure remains an unsolved challenge. In this study, a simple and efficient method is developed that does not require the use of organic solvents to prepare silk fibroin microspheres with a predictable structure. Through extensive screening, the addition of glucose is found to direct the formation of a highly interconnected porous structure from the interior to the surface of silk fibroin microspheres. Compared to silk fibroin microspheres (SF microspheres) produced through a combination of electro‐spray, cryopreservation, and freeze drying, silk fibroin‐glucose microspheres (SF‐Glu microspheres) demonstrates enhanced capabilities in promoting cell adhesion and proliferation in vitro. Both SF‐Glu and SF microspheres exhibit the capacity to maintain the sustained release kinetics of the loaded model drug. Furthermore, SF‐Glu microspheres facilitate the recruitment of endogenous cells, capillary migration, and macrophage phenotype switch following subcutaneous injection in the rats. This study opens a new avenue for the construction of porous silk fibroin microspheres, which could lead to a broader range of applications in regenerative medicine.
Performance Prediction of High‐Entropy Perovskites La0.8Sr0.2MnxCoyFezO3 with Automated High‐Throughput Characterization of Combinatorial Libraries and Machine Learning
Authors: Bozal‐Ginesta Carlota , Sirvent Juande , Cordaro Giulio , Fearn Sarah , Pablo‐García Sergio , Chiabrera Francesco , Choi Changhyeok , Laa Lisa , Núñez Marc , Cavallaro Andrea , Buzi Fjorelo , Aguadero Ainara , Dezanneau Guilhem , Kilner John , Morata Alex , Baiutti Federico , Aspuru‐Guzik Alán , Tarancón Albert 
Published: November 2024

AbstractPerovskite oxides form a large family of materials with applications across various fields, owing to their structural and chemical flexibility. Efficient exploration of this extensive compositional space is now achievable through automated high‐throughput experimentation combined with machine learning. In this study, we investigate the composition–structure–performance relationships of high‐entropy La0.8Sr0.2MnxCoyFezO3±𝞭 perovskite oxides (0 < x, y, z <1; x+y+z≈1) for application as oxygen electrodes in Solid Oxide Cells. Following the deposition of a continuous compositional map using thin‐film combinatorial pulsed laser deposition, compositional, structural, and performance properties are characterized using six different techniques with mapping capabilities. Random forests effectively model electrochemical performance, consistently identifying Fe‐rich oxides as optimal compounds with the lowest area‐specific resistance values for oxygen electrodes at 700 °C. Additionally, the models identify a statistical correlation between oxygen sublattice distortion—derived from spectral analysis of Raman‐active modes—and enhanced performance.