bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Brachiocephalic Vein as a Safe and Viable Alternative to Internal Jugular Vein for Central Venous Cannulation
Authors: Beccaria Paolo Federico , Silvetti Simona , Lembo Rosalba , Landoni Giovanni , Monti Giacomo , Zambon Massimo , Mamo Daniela , Zangrillo Alberto 
Published: April 2018

BACKGROUND:
Although many studies have compared success and complication rates for central line insertion sites with and without ultrasound, few have examined the use of the brachiocephalic vein for central venous access. The aim of this study was to describe the brachiocephalic vein as an alternative site for elective ultrasound vascular cannulation in adults, and to compare it with the more commonly used internal jugular vein site in terms of procedural difficulties, first pass failure rate, overall failure rate, and safety.

METHODS:
In this single-center, retrospective cohort study, clinical data from consecutive adult patients undergoing elective ultrasound-guided central venous catheterization of upper body were retrieved from the department database. All of these central venous catheters were requested by department team, none was positioned for surgery. Seven hundred nine patients underwent central venous catheterization via the internal jugular approach and 285 patients via the brachiocephalic route. Patients catheterized via the brachiocephalic vein approach were then compared with those catheterized via the internal jugular vein in terms of ease of catheterization, success rate, and complications. Differences between approaches were assessed by univariate analyses and multivariable analysis.

RESULTS:
Overall, 994 patients underwent central venous catheterization. A total of 87% had a successful catheter implantation at the first attempt, 6.7% of insertions were difficult, 5.7% were complicated, and 3.4% failed. Procedural difficulty was more frequent with the internal jugular than with the brachiocephalic approach (odds ratio, 0.38; 95% confidence interval, 0.19–0.76; P = .007) after correction for potential confounders. Differences between groups in complication rate (6.3% vs 4.1%) or failure rate (3.4% vs 3.5%) were not significant.

CONCLUSIONS:
Brachiocephalic cannulation is a reasonable alternative to ultrasound-guided internal jugular vein catheterization.
14-3-3 proteins regulate desmosomal adhesion via plakophilins
Authors: Rietscher Katrin , Keil René , Jordan Annemarie , Hatzfeld Mechthild 
Published: April 2018

ABSTRACT
Desmosomes are essential for strong intercellular adhesion and are abundant in tissues exposed to mechanical strain. At the same time, desmosomes need to be dynamic to allow for remodeling of epithelia during differentiation or wound healing. Phosphorylation of desmosomal plaque proteins appears to be essential for desmosome dynamics. However, the mechanisms of how context-dependent post-translational modifications regulate desmosome formation, dynamics or stability are incompletely understood. Here, we show that growth factor signaling regulates the phosphorylation-dependent association of plakophilins 1 and 3 (PKP1 and PKP3) with 14-3-3 protein isoforms, and uncover unique and partially antagonistic functions of members of the 14-3-3 family in the regulation of desmosomes. 14-3-3γ associated primarily with cytoplasmic PKP1 phosphorylated at S155 and destabilized intercellular cohesion of keratinocytes by reducing its incorporation into desmosomes. In contrast, 14-3-3σ (also known as stratifin, encoded by SFN) interacted preferentially with S285-phosphorylated PKP3 to promote its accumulation at tricellular contact sites, leading to stable desmosomes. Taken together, our study identifies a new layer of regulation of intercellular adhesion by 14-3-3 proteins.
Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana
Authors: Abugri James , Ansah Felix , Asante Kwaku P. , Opoku Comfort N. , Amenga-Etego Lucas A. , Awandare Gordon A. 
Published: April 2018

Background: The emergence and spread of resistance in Plasmodium falciparum to chloroquine (CQ) and the antifolate drug sulfadoxine-pyrimethamine (SP) necessitated the change from CQ to artemisinin-based combination therapies (ACTs) as first-line drug for the management of uncomplicated malaria in Ghana in 2005. Methods: To examine the prevalence of molecular markers associated with CQ and antifolate drug resistance in Ghana, we genotyped single nucleotide polymorphisms (SNPs) in the P. falciparum chloroquine resistance transporter (pfcrt, PF3D7_0709000), multidrug resistance (pfmdr1, PF3D7_0523000), bifunctional dihydrofolate reductase-thymidylate synthase (pfdhfr, PF3D7_0417200) and dihydropteroate synthase (pfdhps, PF3D7_0810800) genes in children with malaria reporting to hospitals in three different epidemiological areas of Ghana (Accra, Kintampo and Navrongo) between 2012 and 2017. Results: The overall prevalence of the CQ resistance-associated pfcrt 76T allele was 8%, whereas pfmdr1 86Y and 184F alleles were present in 10% and 65% of infections respectively. Most of the isolates harboured the antifolate resistance-associated pfdhfr 51I, 59R and 108N alleles, including 68% of them with the triple mutant pfdhfr I51R59N108 combination. Pfdhps 437G and 540E were detected in 90.6% and 0.7% of infections, respectively. We observed no significant difference across the three study sites for all the polymorphisms except for pfdhps 437G, which was more common in Accra than at the other sites. Across both pfdhfr and pfdhps genes, a large proportion (61%) of the isolates harboured the quadruple mutant combination (I51R59N108/G437). Conclusion: Comparison of the present results to previously published data shows a significant decrease in the prevalence of CQ resistance alleles during the 12 years after CQ withdrawal, but an increase in the alleles that mediate SP resistance, which could be due to the continuous use of antifolate drugs for prophylaxis.
Identification of human African Trypanosomiasis foci using school-going children in post-conflict era in Nwoya District, Northern Uganda: A cross-sectional study
Authors: Luryama Moi Kenneth , Obol James Henry , Anywar Arony Denis 
Published: April 2018

Background: Human African Trypanosomiasis (HAT) is fatal if untreated; the drugs to treat it are toxic making its management difficult and diagnosis complex. Nwoya district has a long history of sleeping-sickness dating back to pre-colonial times. The civil war of 1986-2008 displaced many who upon return complained of cattle and dogs dying of unknown causes alongside increased tsetse flies infestation hence, the needs for the study. Methods: We enrolled local 3,040 pupils and recorded their social-demographic characteristics and access to different domesticated animals/fowls in their homes. Screening for HAT using the card agglutination test for trypanosomiasis (CATT) was performed; positive individuals had their titres determined, followed by microscopy and loop mediated isothermal amplification analysis (LAMP). R was used for analysis where associations were sought between dependent and independent variables. Any factor with P-value <0.05 was taken as statistically significant. Results: HAT serological prevalence of 1.2% (95% CI 0.8-1.6) was obtained, 58.3% being boys while 41.7% were girls with titres ranging from 1:2 - 1:16. Two schools alone, constituted 47% of the CATT positive cases. Pupils who came from homes with dogs were more likely to be CATT/Trypanosoma brucei gambiense positive; (adjusted odds ratio = 3.12, 95% CI 1.41-6.99 & p=0.005). Conclusions: Though no parasites were detected, with prevalence of CATT positive at 1.2%, active surveillance in the district is still recommended. CATT positive cases needs follow-ups were immune trypanolysis test done to ascertain their exposure.
Classification of processes involved in sharing individual participant data from clinical trials
Authors: Ohmann Christian , Canham Steve , Banzi Rita , Kuchinke Wolfgang , Battaglia Serena 
Published: April 2018

Background: In recent years, a cultural change in the handling of research data has resulted in the promotion of a culture of openness and an increased sharing of data. In the area of clinical trials, sharing of individual participant data involves a complex set of processes and the interaction of many actors and actions. Individual services and tools to support data sharing are becoming available, but what is missing is a detailed, structured and comprehensive list of processes and subprocesses involved and the tools and services needed. Methods: Principles and recommendations from a published consensus document on data sharing were analysed in detail by a small expert group. Processes and subprocesses involved in data sharing were identified and linked to actors and possible supporting services and tools. Definitions adapted from the business process model and notation (BPMN) were applied in the analysis. Results: A detailed and comprehensive tabulation of individual processes and subprocesses involved in data sharing, structured according to 9 main processes, is provided. Possible tools and services to support these processes are identified and grouped according to the major type of support. Conclusions: The identification of the individual processes and subprocesses and supporting tools and services, is a first step towards development of a generic framework or architecture for the sharing of data from clinical trials. Such a framework is needed to provide an overview of how the various actors, research processes and services could interact to form a sustainable system for data sharing.
Texto reescrito, texto esquecido: Philidor, uma pérola queirosiana
Authors: Bishop‑Sanchez Kathryn 
Published: April 2018

TEXT RE‑WRITTEN AND FORGOTTEN: PHILIDOR, A QUEIROSIAN GEM
This study examines Eça de Queirós’s translation of the play Philidor (1863) written by the French author Joseph Bouchardy (1810‑1870). In particular, this study analyzes the circumstances that brought the author to translate this text and the conditions surrounding the circulation and staging of French plays in Portugal at that time. As such I examine Philidor in relation to the strong tradition of French plays translated into Portuguese and Eça’s own comments on the general situation of Portuguese theatre.
D. Teresa, mãe de D. Afonso Henriques, à luz da Crónica de El‑Rey D. Affonso Henriques de Duarte Galvão
Authors: Działak Anna 
Published: April 2018

TERESA, MOTHER OF ALFONSO I OF PORTUGAL, IN THE LIGHT OF THE CRÓNICA DE EL‑REY D. AFFONSO HENRIQUES BY DUARTE GALVÃO: THE ORIGINES REGNI REVISITED
The present article analyzes the Chronicle of Alfonso I of Portugal (Crónica de El‑Rey D. Affonso Henriques) by Duarte Galvão (1445?‑1517). We intend to focus on the origines regni in the light of mythologizing lines and show the functionalization of the historical‑legendary narrative in order to exhibit the heroification of the first King of Portugal and the subsequent (re)creation of his mother’s black legend.
Nem todas as crianças vingam!
Authors: Machado de Paula Júlio Cesar 
Published: April 2018

NOT ALL BABIES HAVE THE LUCK TO BE BORN!: GENEALOGY AND AFRICAN DESCENDANCY IN BRAZILIAN LITERATURE
This paper intends to expose two currents of thought concerning the future of miscegenation and Brazilian ethnic constitution from the late 19th century to the early 20th century. On one hand, we have non‑assimilationist group, characterized here by the expression “realistic pessimism.” And, on the other hand, the majority group, formed by assimilationists and summarized by the expression “genocidal optimism.” Then, three Brazilian authors who deal with the theme are presented as examples: Aluísio Azevedo (O mulato), Machado de Assis (Pai contra mãe) and Nelson Rodrigues (Anjo negro).
Ocorrência e interpretação dos modais poder e dever em português jurídico
Authors: Coelho Ramos Joaquim 
Published: April 2018

OCCURRENCE AND INTERPRETATION OF MODAL VERBS PODER AND DEVER IN PORTUGUESE LEGAL LANGUAGE
In this article, we will try to reflect on how modal verbs poder and dever behave when used in juridical texts. We will focus specifically on its frequency in epistemic, deontic or diffuse usage, as well as on the relevance of context to decode and properly interpret the meaning of these verbs in a given sentence.
Vencedores, heróis, craques… A imagem linguística do êxito desportivo na imprensa eletrónica portuguesa
Authors: Olchówka Anna 
Published: April 2018

WINNERS, HEROES, SUPERSTARS… A LINGUISTIC IMAGE OF SPORT SUCCESS IN PORTUGUESE ELECTRONIC MEDIA
The Internet gave to different media unlimited possibilities of transmission of information. It responds quickly to any contemporary changes, offers a space for open discussion and facilitates exchange of ideas or opinions. The image of a world provided by electronic newspapers has an unparalleled dynamic, and its language is one of the most significant factors. In this context the sport, as one of the key issues in Portuguese media discourse serves as a basis for a linguistic analysis with various interpretations.
De periferia a periferia: constantes e variações na história externa da tradução da literatura polaca em Portugal
Authors: Pięta Hanna 
Published: April 2018

FROM ONE PERIPHERY TO ANOTHER: CONSTANT AND VARIABLE FEATURES OF THE EXTERNAL HISTORY OF TRANSLATION OF POLISH LITERATURE IN PORTUGAL
This article aims at exploring (ir)regularities in the external history of Portuguese translations of Polish literature published in Portugal between 1855 and 2010. Firstly, the state of the art of research on the Portuguese translations of Polish literature is elucidated. Secondly, the results of analysis, guided by six main questions (what is translated, when, by whom, where, how and why?), are presented. Lastly, future research avenues are indicated.
Evaluating Row Cover Establishment Systems for Cantaloupe and Summer Squash
Authors: Hanna fn mi , Steward Brian    L. , Rosentrater Kurt    A. 
Published: April 2018

Abstract.Use of row covers offer an alternative to pesticide application for management of insect feeding and disease transmission and can be beneficial for extending the growing season. Unfortunately, labor required to establish cover is significant (particularly for single rows) and larger pieces of multi-row cover are subject to fatigue from wind and sun. Development of a mechanized single-row cover system or a durable multi-row cover system advances potential for use of covers. Field tests of a commercial semi-mechanized cover implement were conducted. Successful wire insertion ranged from 74% to 100% and depended on careful adjustment of the implement. Success was unaffected by soil type, but partially improved with wetter soil (R2 = 0.37). Keywords: Cucurbit, Disease, Horticulture, Insects, Supports, Tunnels.Costs of a single-row mechanized system using spunbond polypropylene or polyethylene mesh as row covers were compared to those of a conventional chemical application strategy without cover. Total costs of the spunbond polypropylene system were $1620 to $5290 ha-1 ($650 to $2140 acre-1) greater than the conventional system depending on operational size. Smaller production areas were more costly due to machinery costs. The polyethylene mesh system was $1500 ha-1 ($600 acre-1) more costly than using spunbond polypropylene due to material costs. In addition, a multi-row cover system using either of the two types of cover material was investigated including evaluation of support structure during mid-summer field conditions (wind and sun). Sagging cover material over time suggested limiting distance between single supports to 2 m (7 ft) or less. Tennis balls atop single supports avoided cover damage better than rebar caps. Spunbond polypropylene had more tears and damage than polyethylene mesh. Wire hoops spaced 2.3 m along the row avoided cover damage while keeping material off the crop Keywords: Cucurbit, Disease, Horticulture, Insects, Supports, Tunnels.
Advancing Microsoft Excel’s Potential for Teaching Digital Image Processing and Analysis
Authors: Larbi Peter Ako 
Published: April 2018

Abstract. Microsoft Excel is not considered a typical software for digital image processing and analysis. However, based on its large data handling and graphing capabilities, as well as its widespread usage, it presents a good opportunity for use as a tool for teaching image data processing or use in demonstrations requiring little training. It also lends itself well as a potentially useful research tool that can benefit a wide range of users including those with little or no computer programming knowledge. This article demonstrates a new method which can be adopted for teaching concepts of image processing and analysis, consisting of systematic procedures for implementing typical operations in Excel. Categories of operations demonstrated using this method include image preprocessing, image enhancement, image classification, analysis of change over time, and image data fusion. Examples of outputs resulting from using this new method are discussed in the article. The success of this proposed method is hinged on the availability of the required image data, based on which a simple graphical user interface (GUI) application was developed in MATLAB. That application, RGBExcel or the later RGB2X, extracts RGB image data from image files of any format and file size, and exports to Excel for processing. Deployed as standalone applications, both versions can be installed on a 64-bit windows computer and run without MATLAB. Keywords: Color images, Multispectral imagery, Remote sensing, RGB image data, RGB2X, RGBExcel.
Methane/Gasoline Bi-fuel Engines as a Power Source for Standard Agriculture Tractors: Development and Testing Activities
Authors: Bisaglia Carlo , Brambilla Massimo , Cutini Maurizio , Fiorati Stefano , Howell Mark 
Published: April 2018

Abstract. Promoting energy efficiency in agriculture means supporting economic growth by reducing both pollution and greenhouse gas (GHG) emissions while minimizing waste and the inefficient use of natural resources. Biomethane presents an interesting option given its possibility to be produced from livestock waste or other organic residues, with GHG emission savings ranging from 84% to 86% (wet or dry manure). Moreover, experiences with methane-fueled engines are widely available, thus leading to considering the possibility of using such a fuel in the agricultural sector as well. The aim of this research was to develop a first-generation tractor prototype provided with a commercially available bi-fuel engine adapted for the purpose and tested both in laboratory and field conditions. The main design aspects are depicted while the performance results show similar values of engine power and torque (87 kW maximum power for the diesel fuel tractor and 88 kW for the methane-fueled version; 1172 Nm maximum torque at 550 min-1 for the methane and 1155 Nm at 400 min-1 for the diesel tractor) with an autonomy of the methane prototype which is, at present, 40% of a comparable standard tractor. The possible role in farm fleet is also presented. Keywords: Agricultural machinery, CNG, Gaseous bio-fuels, Renewable fuels.
Daystar/Rosalie Jones, ‘Dancing the Four Directions’
Authors: Shea Murphy Jacqueline 
Published: April 2018

Abstract
Dance scholar Jacqueline Shea Murphy introduces Daystar/Rosalie Jones, who created the first Native contemporary dance company, DAYSTAR Dance Drama of Indian America, in 1980 (and who describes her recent work Dancing the Four Directions in this special issue). Shea Murphy first situates her professional relationship with Daystar/Rosalie, which spans over two decades. She then situates Daystar/Rosalie’s work in the context of this special issue, giving a brief overview of some of the dances she has made over nearly half a century, dances centred within Indigenous cultural story and mythic image, and grounded, directly or indirectly, in relation to place.
Comparison of Si and SiC based Power Converter Module of 150 kVA for Power System Applications
Authors: Štěpánek Jan , Streit Luboš , Komrska Tomáš 
Published: April 2018

The paper deals with the comparison of power semiconductors based on Si and SiC in application of power converters for power systems. These are single-phase voltage-source bridge inverters with nominal power of 150 kVA. Power converters are designed to operate under both active power and reactive power. Mechanical design of the converters is ready for interchange the power semiconductor modules and assess the operation with both, Si and SiC technology.
Asymptotic stability of nonlinear integrodifferential equation
Authors: Jackreece Prebo , Aniaku Stephen 
Published: April 2018

The investigation of stability for nonlinear dynamical system often related to the construction of Lyapunov functionals. We employ Lyapunov functionals to the system of nonlinear Volterra integro-differential equations of the form Â and obtain conditions for the asymptotic stability of the zero solution. Also, we give examples to illustrate the obtained results.
Lagrangian calculus for nonsymmetric diffusion operators
Authors: Ketterer Christian 
Published: April 2018

Abstract
We characterize lower bounds for the Bakry–Emery Ricci tensor of nonsymmetric diffusion operators by convexity
of entropy and line integrals on the

L
2

{L^{2}}

-Wasserstein space, and
define a curvature-dimension condition for general metric measure spaces together with a square integrable 1-form in the sense of [N. Gigli,
Nonsmooth differential geometry—an approach tailored for spaces with Ricci curvature bounded from below,
Mem. Amer. Math. Soc. 251 2018, 1196, 1–161].
This extends the Lott–Sturm–Villani approach for lower Ricci curvature bounds of metric measure spaces. In generalized smooth context, consequences are new Bishop–Gromov estimates, pre-compactness under measured Gromov–Hausdorff convergence, and a Bonnet–Myers theorem that
generalizes previous results by Kuwada [K. Kuwada,
A probabilistic approach to the maximal diameter theorem,
Math. Nachr. 286 2013, 4, 374–378]. We show that N-warped products together with lifted vector fields satisfy the curvature-dimension condition. For smooth Riemannian manifolds, we derive an evolution variational inequality and contraction estimates for
the dual semigroup of nonsymmetric diffusion operators. Another theorem of Kuwada [K. Kuwada,
Duality on gradient estimates and Wasserstein controls,
J. Funct. Anal. 258 2010, 11, 3758–3774], [K. Kuwada,
Space-time Wasserstein controls and Bakry–Ledoux type gradient estimates,
Calc. Var. Partial Differential Equations 54 2015, 1, 127–161] yields Bakry–Emery gradient estimates.