bluuebunny/crossref_metadata_2025_split huggingface dataset:
Como fazer a angústia falar na clínica?
Authors: Martinho Maria Helena Coelho 
Published: November 2024

Este texto apresenta fragmentos de um caso clínico de uma menina de nove anos de idade, que ilustra uma relação singular entre a angústia e a fobia em dois tempos: em um primeiro tempo, o objeto fóbico desempenha sua função de proteção contra a angústia, substitui a angústia insondável que precede a fobia, serve para metaforizar a angústia, para convertê-la em medo; em um segundo tempo, ocorre uma falha no inteligente mecanismo de defesa, o objeto fóbico não pode mais cumprir a função de proteção contra a angústia e as graves crises de angústia emergem com toda a sua intensidade. A tradução feita por Lacan no nó borromeano da tríade freudiana Inibição, Sintoma e Angústia (1974-1975) é tomada para fundamentar o que se desvela na clínica, a angústia como um transbordamento do real, no campo do imaginário do corpo, em conexão com o gozo do Outro. O texto destaca os efeitos que o trabalho de análise promove sobre a angústia desse sujeito.
“The Story of Makanuna” Poem
Authors: Abbas Malak Alaa Eldeen , Spencer Henry , Dahab Hadeer Saeed 
Published: November 2024

"Welcome to 'Makanuna', our place … home of our inner spirit A trove of things crafted by our hands … is waiting for you to find inside this space." Malak Alaa Eldeen, 2023
Makanuna Al-Khalifa was a participatory placemaking project empowering adolescents in al-Khalifa neighbourhood in historic Cairo to redesign their local public spaces. Through 2021-2022 workshops, around 20 youth aged 13-18, including Malak Alaa Aldeen, upcycled solid and organic waste into outdoor furniture, games, and compost for al-Khalifa Park. A key output was Malak’s poem “The Story of Makanuna” with illustrations by her sister Fatma Alaa Eldeen, also a workshop participant. In vivid verses, the 17-year-old welcomes readers to “Makanuna” - Arabic for “Our Space” - home to their creativity and handcrafted items. She describes making a gazebo “formed from three triangles” of repurposed plastic bottles and rope, illuminated to resemble “a rainbow”, delighting all who see it. Inspired, they crafted five more lighting units “with bold colours and innocent hands.”The poem conveys their determined spirit driving this unique space’s creation through hard work “from our plans.” Malak radiates pride in resourceful designs like a recycling bin filled with bottles containing natural materials from the park. Her closing words capture their ownership: “Here is our place and our story. So, what do you think of our idea in all its glory?”Empowering youth to transform underutilized areas fostered creativity, environmental stewardship and belonging. Building on this, Malak, Fatma and other core team members launched “Makanuna Initiative” to pursue placemaking further. Malak now voices this youth-led initiative’s junior team, aiming to inspire wider involvement. Malak’s poem and Fatma’s illustrations powerfully capture their sustainable accomplishments. This highlights the initiative’s origins in the Al-Khalifa workshops through adolescent participants who helped catalyse Makanuna’s growth from a local project into a youth-led movement.
FAKTOR PENYEBAB TIDAK DITEMUKANNYA BRM CANCER DAN CANCER OBGYN PADA BAGIAN RISET DAN PENELITIAN RS X
Authors: Khatimah Nurul 
Published: November 2024

Rekam medis adalah dokumen yang berisi informasi tentang identitas pasien, pemeriksaan medis, pengobatan, tindakan, dan layanan lain yang diberikan kepada pasien. RS X adalah rumah sakit pendidikan yang juga menjadi rujukan pusat nasional di Indonesia termasuk kasus cancer dan cancer obgyn. Karena jumlah kunjungan pasien rawat jalan yang tinggi, permintaan berkas rekam medis juga meningkat. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor penyebab tidak ditemukannya berkas rekam medis cancer dan cancer obgyn pada bagian riset dan penelitian dengan menggunakan 5 M. Jenis penelitian adalah penelitian kualitatif dengan cara observasi dan wawancara. Hasil penelitan menunjukkan dari faktor man yaitu kurangnya petugas sehingga menyebabkan tingginya beban kerja, dari faktor material yaitu rak penyimpanan yang berdekatan, sempit sehingga menyulitkan dalam pengambilan, dari faktor method yaitu tidak adanya SPO, dari faktor money yaitu pengadaaan sarana pendukung dalam pelayanan, penyimpanan, dan pendistribusian belum terpenuhi, dari faktor machines yaitu hanya terdapat 2 komputer yang digunakan untuk keperluan penyediaan berkas rekam medis.
Differential regulation of tissue-resident and blood-derived macrophages in models of autoimmune and traumatic peripheral nerve injury
Authors: Sprenger-Svačina Alina , Svačina Martin K. R. , Gao Tong , Ritzel Rodney M. , McCullough Louise D. , Sheikh Kazim A. , Zhang Gang 
Published: November 2024

IntroductionThe current study focuses on understanding the functional role of different subsets of endoneurial macrophages in autoimmune polyneuropathies (AP) and traumatic peripheral nerve injury (TPNI), which holds potential for clinical application. Recent studies have advanced our understanding of the diverse origins of macrophages within peripheral nerves. However, there remains a gap in our knowledge regarding how endoneurial macrophages from different origins affect disease progression in AP versus TPNI.MethodsFlow cytometry was utilized to analyze macrophage phenotypes, including polarization states, cytokine production, and myelin phagocytosis in animal models of AP and TPNI. This study focuses on two distinct origins of macrophages, namely CD11b+F4/80hi tissue-resident (TRM) and CD11b+F4/80int blood-derived macrophages (BDM). The study utilized two animal models: the first was the spontaneous autoimmune peripheral polyneuropathy (SAPP) model in B7.2-null non-obese diabetic (NOD-B7.2-/-) mice, which serves as a model for inflammatory demyelinating polyneuropathy; the second model involved wild type C57BL/6 mice subjected to sciatic nerve crush injury, modeling TPNI. Behavioral, electrophysiological, and histological analyses were performed to assess peripheral nerve injury.ResultsThe study found that pro-inflammatory M1 macrophage polarization and tumor necrosis factor-alpha production by macrophages were more pronounced in the peripheral nerves of SAPP mice compared to those with TPNI, with the majority of these macrophages being TRM. In contrast, endoneurial macrophages in mice with TPNI were mainly BDM, exhibiting a less defined macrophage polarization and cytokine profile than TRM in AP mice. Interestingly, myelin phagocytosis was primarily driven by BDM in both SAPP and TPNI mice.DiscussionThis study offers novel insights into origin-dependent macrophage functions in AP and TPNI. Furthermore, these findings may help the future development of novel therapies targeting macrophage subsets of specific origin in AP and TPNI.
A novel method for optimizing epilepsy detection features through multi-domain feature fusion and selection
Authors: Kong Guanqing , Ma Shuang , Zhao Wei , Wang Haifeng , Fu Qingxi , Wang Jiuru 
Published: November 2024

BackgroundThe methods used to detect epileptic seizures using electroencephalogram (EEG) signals suffer from poor accuracy in feature selection and high redundancy. This problem is addressed through the use of a novel multi-domain feature fusion and selection method (PMPSO).MethodDiscrete Wavelet Transforms (DWT) and Welch are used initially to extract features from different domains, including frequency domain, time-frequency domain, and non-linear domain. The first step in the detection process is to extract important features from different domains, such as frequency domain, time-frequency domain, and non-linear domain, using methods such as Discrete Wavelet Transform (DWT) and Welch. To extract features strongly correlated with epileptic classification detection, an improved particle swarm optimization (PSO) algorithm and Pearson correlation analysis are combined. Finally, Support Vector Machines (SVM), Artificial Neural Networks (ANN), Random Forest (RF) and XGBoost classifiers are used to construct epileptic seizure detection models based on the optimized detection features.ResultAccording to experimental results, the proposed method achieves 99.32% accuracy, 99.64% specificity, 99.29% sensitivity, and 99.32% score, respectively.ConclusionThe detection performance of the three classifiers is compared using 10-fold cross-validation. Surpassing other methods in detection accuracy. Consequently, this optimized method for epilepsy seizure detection enhances the diagnostic accuracy of epilepsy seizures.
Complex aortic valve repair in congenital patients: clinical feedback
Authors: Barbier Marie-Anne , Bulescu Nicolae Cristian , Metton Olivier , Bou Karam Lea , Martin Bonnet Caroline , Moulin Zinsch Anne , Lilot Marc , Henaine Roland 
Published: November 2024

IntroductionIn the congenital population, particularly in young adults, the best strategy for aortic valve surgery has not been clearly established. This study investigates the mortality, perioperative morbidity and echocardiographic evolution of complex aortic valve repair techniques.Material and methodsWe performed a retrospective monocentric descriptive study of patients operated at the Louis Pradel Hospital (Lyon) from 2017 to 2023. We included patients operated for complex aortic valve repair by the congenital heart surgery team, excluding simple commissurotomies. The primary endpoint was postoperative survival. The secondary endpoints were freedom from surgical reintervention and echocardiographic evolution of aortic regurgitation, aortic stenosis and annular diameter. The analysis was performed using Kaplan Meier methods.ResultsTwenty-eight patients were included. The mean age was 11.1 years (range 1–35 years) and the mean weight was 37.5 kg (range 8.2–79 kg). The postoperative survival rate was 96.4% at discharge (27/28 patients). The mean follow-up interval was 35 months (range 14–79 months). At the end of the follow-up, the freedom from reoperation was 85.7%. Four patients underwent reoperation for worsening aortic valve and/or ventricular function (1 heart transplantation, 2 Ross procedures, 1 aortic valve replacement). Results on secondary endpoints showed a trend towards improvement in annular diameter postoperatively between pre- and postoperative echocardiography for each patient, with no statistically significant difference for aortic insufficiency, but for aortic stenosis (p = 0.02).ConclusionThis study shows an excellent survival rate, and a similar risk of reintervention compared with literature data. All the data described above argue in favor of an aortic valve repair surgery as a first line procedure in case of congenital heart disease.
Impact of the deep squat on articular knee joint structures, friend or enemy? A scoping review
Authors: Rojas-Jaramillo Andrés , Cuervo-Arango Daniel A. , Quintero Juan D. , Ascuntar-Viteri Juan D. , Acosta-Arroyave Natalia , Ribas-Serna Juan , González-Badillo Juan José , Rodríguez-Rosell David 
Published: November 2024

BackgroundThe squat exercise has been shown to improve athletic performance. However, the use of the deep squat has been questioned due to claims that it may cause knee joint injuries. Therefore, the purpose of this scoping review was to synthesize existing literature concerning the impact of deep squats on knee osteoarticular health in resistance-trained individuals.MethodsThis study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines. The original protocol was prospectively registered in Figshare (https://doi.org/10.6084/m9.figshare.24945033.v1). A systematic and exhaustive search was conducted in different databases: PubMed, Scopus, Web of Science, and SPORTDiscus. Additional searches were performed in Google Scholar and PEDro. The main inclusion criteria were the following: (1) Articles of experimental, observational, or theoretical nature, including randomized controlled trials, longitudinal studies, case reports, integrative reviews, systematic reviews, and meta-analyses(Primary studies were required to have a minimum follow-up duration of 6 weeks, whereas secondary studies were expected to adhere to PRISMA or COCHRANE guidelines or be registered with PROSPERO; (2) Peer-reviewed articles published between 2000 and 2024; (3) Publications written in English, Spanish and Portuguese; (4) Studies reporting the effects of deep half, parallel or quarter squats on the knee or evaluating squats as a predictor of injury.ResultsThe keyword search resulted in 2,274 studies, out of which 15 met all inclusion criteria. These 15 studies comprised 5 cohort studies, 3 randomized controlled trials, 4 literature or narrative reviews, 1 case study, and 2 systematic reviews, one including a meta-analysis. Overall, the risk of bias (ROB) across these studies was generally low. It is worth noting that only one study, a case study, associated deep squats with an increased risk of injury, the remaining 14 studies showed no negative impact of deep squats on knee joint health.ConclusionThe deep squat appears to be a safe exercise for knee joint health and could be included in resistance training programs without risk, provided that proper technique is maintained.
Changes in the Gut and Oral Microbiome in Children with Phenylketonuria in the Context of Dietary Restrictions—A Preliminary Study
Authors: Ostrowska Malgorzata , Nowosad Karolina , Mikoluc Bozena , Szczerba Hubert , Komon-Janczara Elwira 
Published: November 2024

Background: Phenylketonuria (PKU) is a metabolic disorder that necessitates dietary restrictions, potentially impacting the composition of gut and oral microbiota. This study aimed to compare the microbiota composition between children with PKU and healthy controls. Methods: Using 16S rRNA gene sequencing, we analysed microbial communities at six phylogenetic levels. Results: Our findings revealed significant differences in the gut microbiota: Euryarchaeota was more abundant in controls (p = 0.01), while Bacilli and Lactobacillales were higher in PKU children (p = 0.019). Methanobacteriales were significantly elevated in controls (p = 0.01). At the genus and species levels, PKU children had higher Streptococcus and Eubacterium dolichum (p = 0.019, p = 0.015), whereas controls had more Barnesiella, Coprococcus, and Faecalibacterium prausnitzii (p = 0.014, p = 0.019, p = 0.014). In the oral microbiota, control children exhibited significantly higher Bacteroidetes (p = 0.032), while PKU children had increased Bacilli and Betaproteobacteria (p = 0.0079, p = 0.016). Streptococcus and Neisseria were more prevalent in PKU (p = 0.0079, p = 0.016). Conclusions: These results suggest that PKU and its dietary management significantly alter the gut and oral microbiota composition. Understanding these microbial shifts could have implications for managing PKU and improving patient outcomes.
La consolidación de la identidad nacional. Una tarea pedagógica de la escuela cubana
Authors: Alarcón Quintana Eduardo , Cortón Romero Blanca 
Published: November 2024

En el mundo actual, la consolidación de la identidad nacional debe ser una prioridad para los países. La escuela y los maestros son esenciales para lograr este objetivo, ya que existe una conexión entre la identidad nacional y la actividad educativa. La creación de formas de actuación profesional docente enfocadas en estas metas es necesaria y tiene un significado especial en Cuba, ya que desde el ámbito educativo se debe fomentar el sentimiento de pertenencia y patriotismo. Este artículo tiene como objetivo examinar esta cuestión. Se requirió la implementación de un conjunto de técnicas, que incluían análisis y síntesis, sistematización teórica, triangulación de fuentes y hermenéutica.
Aplikasi Model ARIMA dalam Peramalan Produk Domestik Regional Bruto (PDRB) Pertambangan dan Penggalian Kalimantan Selatan
Authors: Hayati Lia Aulia , Agustina Neli 
Published: November 2024

Produk Domestik Regional Bruto (PDRB) sektor pertambangan dan penggalian merupakan salah satu sektor unggulan yang ada di Kalimantan Selatan. Namun, keterbatasan sumberdaya pertambangan dan penggalian menjadi ancaman bagi perekonomian Kalimantan Selatan. Peramalannya dilakukan untuk melihat prospek sektor pertambangan dan penggalian, selain itu pemerintah dalam RPJMN tahun 2020-2024 menargetkan laju pertumbuhan ekonomi sektor pertambangan mencapai angka 1,9 - 2,0 persen. Penelitian ini bertujuan untuk meramalkan nilai PDRB sektor pertambangan dan penggalian di Kalimantan Selatan. Metode peramalan yang digunakan yaitu model ARIMA. Hasil penelitian menunjukkan bahwa didapatkan model terbaiknya adalah model ARIMA (2,1,4) dengan tingkat akurasi MAPE yaitu 5,054 persen. Nilai PDRB sektor pertambangan dan penggalian diramalkan terus meningkat pada tahun 2024. Hasil dari penelitian ini diharapkan dapat menjadi informasi untuk pihak yang terkait untuk menetapkan kebijakan yang relevan untuk menjaga dan meningkatkan sektor pertambangan khususnya di Kalimantan Selatan, apalagi petambangan dan penggalian merupakan sektor dengan serapan tenaga kerja yang tinggi.
Недилатационная кардиомиопатия левого желудочка: новый фенотип кардиомиопатии, предложенный экспертами Европейского общества кардиологов
Authors: С.М. Комиссарова , Н.М. Ринейская , Н.Н. Чакова , С.С. Ниязова , А.А. Ефимова 
Published: November 2024

Эксперты Европейского общества кардиологов (ESC) обновили рекомендации по диагностике и лечению пациентов с кардиомиопатиями и предложили новое клиническое определение недилатационной кардиомиопатии левого желудочка. Особое внимание уделено критериям диагностики этой патологии и профилактике внезапной сердечной смерти с учетом данных генотипирования пациентов. Фенотип недилатационной кардиомиопатии левого желудочка включает лиц с дилатационной кардиомиопатией, но без дилатации левого желудочка; аритмогенную кардиомиопатию левого желудочка; леводоминантную аритмогенную кардиомиопатию правого желудочка или аритмогенную дилатационную кардиомиопатию (но часто без соответствия диагностическим критериям для аритмогенной кардиомиопатии правого желудочка). Наиболее часто генетическими причинами недилатационной кардиомиопатии левого желудочка являются варианты в генах DSP, FLNC, DES, LMNA и PLN, при этом существует значительное пересечение с генами, ассоциированными с дилатационной кардиомиопатией и аритмогенной кардиомиопатией правого желудочка. В представленной статье освещены основные аспекты диагностики и опыт практического применения новых критериев для распознавания фенотипа недилатационной кардиомиопатии левого желудочка на примере двух пациентов с новыми вероятно патогенными вариантами: делеция c.6466_6467del (p.Arg2156fs*8) в гене DSP и вариант в акцепторном сайте сплайсинга c.2656-1G>A в гене RBM20.
The experts of the European Society of Cardiology (ESC) have provided new Guidelines for the management of cardiomyopathies and proposed a novel clinical definition of non-dilated left ventricular cardiomyopathy (NDLVC). Particular attention has been paid to the criteria for practical diagnostic and treatment framework for patients, notably the prevention of sudden cardiac death, considering genotyping data. The phenotype of NDLVC includes individuals with dilated cardiomyopathy (DСM), precisely without left ventricular dilation; arrhythmogenic left ventricular cardiomyopathy; left-dominant arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic DCM (scarcely meeting the diagnostic criteria for ARVC). The predominant genetic causes of NDLVC are variants in DSP, FLNC, DES, LMNA and PLN genes, while there is significant overlap with genes associated with DCM and ARVC. The presented article highlights the main aspects of diagnosis and the experience of practical application of new criteria for the recognition of the NDLVC phenotype on the grounds of two clinical cases with new likely pathogenic variants: deletion c.6466_6467del (p.Arg2156fs*8) in DSP gene and a variant in the acceptor splicing site c.2656-1G>A in RBM20 gene.
Первые результаты выполнения баллонной митральной вальвулопластики без применения рентгеноскопии
Authors: В.М. Им 
Published: November 2024

Цель. Провести оценку опыта выполнения и результатов баллонной митральной вальвулопластики (БМВ) по методике Inoue стеноза митрального клапана (МК) ревматической этиологии под контролем эхокардиографии (ЭхоКГ) без применения рентгеноскопии. Материалы и методы. В исследование включены 4 пациента с митральным стенозом (МС), которым с 2019 по 2022 г. на базе ГУ «РСНПМЦХ им. акад. В. Вахидова» была выполнена БМВ по технике Inoue только под контролем ЭхоКГ. Исследования проводились согласно общепринятым протоколам. При выполнении БМВ каждый этап контролировался под ЭхоКГ без рентгеноскопии и использования контрастного вещества. После каждого этапного баллонного расширения проводился ЭхоКГ- контроль площади митрального отверстия (МО), градиента и степени митральной регургитации. Результаты. Все процедуры БМВ, включенные в исследование, завершены успешно. Применение ЭхоКГ для контроля вмешательства позволяет ограничить применение рентген-излучения для визуализации этапов. Заключение. У пациентов с МС проведение БМВ под ЭхоКГ-контролем является безопасным и эффективным методом лечения. Применение данного метода особенно полезно у беременных и у пациентов с хронической почечной недостаточностью и МС.
Purpose. To evaluate experience with and outcomes of performing balloon mitral valvuloplasty (BMV) using the Inoue technique for rheumatic mitral valve stenosis (MS) under echocardiographic (EchoCG) guidance without fluoroscopy. Materials and methods. The study included four patients with mitral stenosis who underwent BMV using the Inoue technique exclusively under EchoCG guidance between 2019 and 2022 at the Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V. Vakhidov. The procedures were conducted according to standard protocols. Each stage of BMV was monitored using EchoCG without fluoroscopy or contrast agents. After every stage of balloon dilation, EchoCG was performed to assess the mitral orifice area, gradient, and the mitral regurgitation degree. Results. All BMV procedures included in the study were successfully completed. The use of EchoCG to guide the intervention allowed limiting the use of radiation for visualization. The outcomes of BMV under EchoCG guidance were comparable to those of the procedure performed under fluoroscopic control. Conclusion. BMV under EchoCG guidance in patients with MS is a safe and effective treatment method. This approach is particularly beneficial for pregnant women and patients with chronic renal failure and MS.