bluuebunny/crossref_metadata_2025_split huggingface dataset:
INOVASI PENDIDIKAN AGAMA ISLAM DI SEKOLAH UMUM
Authors: Nur Huda  , Mahfud  
Published: November 2024

Pendidikan umum di negeri ini memiliki sejarah tersendiri yang berbeda dengan pendidikan agama. Dalam sejarahnya, pendidikan umum lebih menargetkan lulusan yang menguasai ilmu sains dan teknologi. Pendidikan Agama Islam di sekolah umum belum mendapatkan porsi perhatian yang semestinya. Padahal pengetahuan ilmu agama – khususnya Islam -- pada seorang muslim menjadi sangat penting untuk bekal dalam kehidupannya. Ini menjadi problem tersendiri jika tidak dilakukan inovasi. Tulisan ini memaparkan inovasi yang dilakukan oleh pengambil kebijakan dan oleh guru Pendidikan Agama Islam di sekolah umum untuk meningkatkan efektifitas pembelajaran PAI di sekolah umum. Inovasi dapat dilakukan di level pengambi kebijakan dengan memasukkan kurikulum PAI di sekolah umum. Inovasi dapat berupa pemberian ekstrakurikuler PAI dengan memberi pembelajaran baca al Qur’an dan pelajaran fiqh. Inovasi juga dilakukan dengan mengadakan pesantren kilat, pondok Romadhan di sekolah umum, serta penggunaan pembelajaran PAI berbasis digital dalam beberapa pelajaran tertentu.
MANAJEMEN PERGURUAN TINGGI ISLAM BERBASIS PESANTREN
Authors: Slamet  , Mohammad Nurul Huda  
Published: November 2024

This study aims to determine the implementation of management functions, student management, academic culture development management and alumni management at Islamic religious colleges based on pesantren. The method used in this research is descriptive qualitative. The data in this study were obtained from interviews, observations and documentation with the research subjects, namely the head of STAI Luqman Al-Hakim, the vice chairman of student affairs, the head of caring and alumni. The findings of this study PTAI and Islamic Boarding School are able to integrate to achieve the goal of excellence from the uniqueness of PTAI as an academic entity by giving birth to scholars and boarding schools with its function as a preacher / cleric printer. Management functions are aligned and optimal when the vision and orientation are clear and measurable, namely the birth of cadre scholars. Student management is integrated between the development of academic culture and pesantrenan with the optimization of resources, methods of fostering the character of the quran, pesantren culture, educative rules and means (mosques, dormitories, campuses, pesantren) to give birth to alumni who are ready to carry out the task of developing organizations.
PERPUSTAKAAN SEKOLAH DAN MINAT BACA SISWA SD AL-HIKMAH SURABAYA
Authors: Damanhuri  , Kartika Indah Tungga Dewi  
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan pengelolaan perpustakaan SD Al Hikmah Surabaya dalam meningkatkan minat baca siswa. Penelitian dilakukan dengan pendekatan kualitatif deskriptif fenomenologis. Data dikumpulkan dengan metode wawancara terprogram, observasi non partisipan, dan dokumentasi. Teknik analisis data dengan proses reduksi data, display data dan kesimpulan melalui verifikasi data. Untuk memastikan data yang diperoleh akurat, peneliti melakukan uji keabsahan data dengan teknik triangulasi. Hasil penelitian menunjukkan bahwa pengelolaan perpustakaan sekolah dalam meningkatkan minat baca siswa sudah baik terbukti dengan data minat baca siswa di SD Al Hikmah Surabaya sangat tinggi yang diukur berdasarkan peminjaman buku siswa di perpustakaan. Perpustakaan SD Al Hikmah Surabaya meluncurkan aplikasi perpustakaan online melalui aplikasi e-sekolahku dan WA Centre. Aplikasi ini memungkinkan siswa-siswi memesan buku dari rumah dan buku akan dikirimkan ke alamat peminjam. Keberhasilan peningkatan minat baca siswa ini juga tersebab perpustakaan sekolah melibatkan orang tua dalam pemantauan perkembangan literasi siswa.
IMPLEMENTASI KURIKULUM ADAB DI SEKOLAH
Authors: Muh Idris  
Published: November 2024

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan adab serta mengetahui macam-macam adab apa saja yang diterapkan di Sekolah secara lebih mendalam. Selain itu upaya-upaya apasaja yang dilakukan untuk membetuk karakter pembiasaan adab pada peserta didik.
Metode penelitian menggunakan pendekatan kualitatif dengan menggunakan pendekatan naturalistis. Dalam penelitian ini, penulis bertindak sebagai pengumpul data dan sebagai instrumen aktif. Sumber data dalam penelitian ini ada dua yakni, sumber data primer dan sekunder.
Berdasarkan penelitian disimpulkan bahwa implementasi kurikulum adab di Sekolah ada dua macam yaitu adab menutut ilmu dan adab keseharian. Adab menuntut ilmu diberikan dan diaplikasikan pada saat peserta didik melakukan pembelajaran baik di akademik maupun dipembelajaran diniyah. Sedangkan adab keseharian perserta didik lebih diaplikasikan pada saat berada di asrama. Yang mana peserta didik teori/ materi-materi adab, dan setelah itu peserta didik diminta untuk mempraktikkan dalam kehidupan sehari-hari, serta yang tidak kalah pentingnya adanya keteladanan dari semua warga dan ustadzah yang ada dilingkungan pesantren.
Assessing the Validity and Reliability of the Arabic Version of the Locomotor Capabilities Index in Adults with Lower Limb Amputation: Cross-cultural Adaptation Study
Authors: Alnamankany Eman , Wesam Qurban  , Eid Marwa 
Published: November 2024

Background: Amputations can significantly negatively impact an individual’s economic status, psychological health, and social life. The Locomotor Capabilities Index (LCI) measures how well people with lower-limb amputation can use prostheses to carry out activities. The validity and reliability of the Arabic version of the LCI were assessed in this study. Methods: The English Locomotor Capabilities Index had been translated forward and backward for cross-cultural adaptation to Arabic (LCI). The subsequent Arabic (SAUDI) LCI was then administered to fifty-seven patients with amputation; thirteen of them were women with a mean age of 53 years (ranging from 29 to 71), while forty-four were men with a mean age of 55 years (ranging between 20 and 85 years). All patients were trained in Al Nour Rehabilitation training centre – in Mecca -KSA. The validity and reliability of the Arabic LCI were evaluated through several measures. In two different subgroups of 20 and 30 amputation patients, the Arabic LCI was compared to the Time Up-and-Go test (TUG) and the Index of EQ-5D Health Utility to assess its structural validity. Scores from various age groups were compared to determine the discrimination value. Thirty individuals with amputations underwent test-retest reliability (7–14 day) evaluations. Results: The Arabic LCI demonstrated good converging structure validity, exhibiting a strong correlation with TUG (r = 0.79 & 95%CI - 0.90- 0.60) and EQ-5D (r= 0.81,95%CI 0.61- 0.92), as well as discriminatory effect, with mean scores for older amputees significantly lower than for younger amputees (p < 0.001)) and high internal consistency (Cronbach alpha 0.93 ) (CI 95 % 0.91-0.94). Test-retest reliability for unilateral amputees had an intraclass correlation coefficient of 0.93 (95 % CI 0.83-0.92). 17.5 % of the cases involved the ceiling effect. The ceiling effect occurred in 17.5% of the cases. Conclusion: The Arabic version of the LCI has shown strong internal consistency and validity in adults with amputation.
Pain Neuroscience Education Training Enhances Pain Knowledge Among A Sample of Saudi Physiotherapists but does not Alter Attitudes or Beliefs
Authors: Aldera Mai 
Published: November 2024

Background: Pain management for patients with chronic pain requires a comprehensive biopsychosocial approach that includes pain neuroscience education. Physiotherapists play a crucial role in delivering pain education and require a strong understanding of pain neuroscience education to enable them to tailor individual patient education, refine clinical decision-making, and potentially address central sensitization. However, limited research explores the Saudi physiotherapists' knowledge and attitudes towards pain neuroscience education. Objectives: This study investigated the impact of pain neuroscience education training on physiotherapists' knowledge, attitudes and beliefs towards working with people with chronic pain. Methods: Twenty-six physiotherapists participated in a 3-day, 21-hour intensive pain neuroscience education training program aligned with International Association for the Study of Pain (IASP) standards. The program included lectures, case studies, and group discussions led by a pain rehabilitation expert. Participants completed the Health Care Pain Attitudes and Impairment Relationship Scale (HC-PAIRS) and the Revised-Neuroscience Pain Questionnaire (R-NPQ) before and after the training. Results: Knowledge scores (R-NPQ) significantly increased post-intervention (p < .001), with a greater number of correct responses and fewer incorrect responses. No significant changes were observed in attitudes towards chronic pain patients (HC-PAIRS, p = .99). Conclusion: This study demonstrates that a structured pain neuroscience education (PNE) training program can significantly enhance the knowledge of Saudi physiotherapists. However, it highlights a potential gap in influencing attitudes towards chronic pain patients. Future research should explore the effectiveness of multi-component interventions, including clinical supervision, to foster long-term behavioural changes aligned with biopsychosocial principles of pain management.
Effect of Myringotomy in Hearing Improvement in Children of Otitis Media With Effusion, A Pre-post Quasi Experimental Trail
Authors: Hadia Sultan  
Published: November 2024

Objective: The objective of the study is to determine effectiveness of myringotomy in hearing improvement in children of otitis media with effusion.Methodology: A descriptive study was conducted among the 73 candidates who were suffering from otitis media with effusion. Both male and the female were included with age ranges from 5-12 years .Data was collected on the performa by doing the hearing assessment of the participants before the surgical procedure of myringotomy and after the myringotomy. Paired sample t test was applied to determine the mean PTA difference before and after surgery.Results: For right ear, before surgery PTA score was 1.77±1.05 and it improves to 1.25±1.71 after myringotomy. The difference was statistically significant (p-value <0.001). Similarly for left ear mean PTA score was 2.25±1.71 and after surgery the mean score improves to 0.70±1.02. The difference was statistically significant (p-value <0.001).Conclusion: It is concluded that there is an significant improvement in hearing thresholds of the children suffering from otitis media with effusion after the surgical treatment of myringotomy.Key words: Myringotomy, Hearing, Children, Otitis Media with Effusion
A Study on Seroprevalence of ABO Blood groups in Lahore, Pakistan
Authors: Sidra Shaheen  , Faisal Nouroz  
Published: November 2024

Objective: The blood group system (ABO) and Rhesus genes (Rh) phenotypes vary widely between populations and ethno-geographical areas.The present study aimed to determine the distribution of ABO and Rh groups in a subset of population from Lahore, Pakistan.
Methodology: The study included 1000 subjects (76.1% males and 23.9% females) from INMOL hospital, Lahore. Forward grouping was performed by using antigen-antibody agglutination method.
Results: The distribution of phenotypes in the total sample was 23.9%, 35.2%, 8.8% and 32.1% for groups A, B, AB and O respectively. However, the seroprevalence of Rh positive (R) and Rh negative (r) was 91.7% and 8.3%, respectively.
Conclusion: It was concluded that blood group B had highest prevalence and AB was the least frequent in population from Lahore and surroundings. This data may be helpful in keeping record for the management of availability of blood for crises. Also, it represents the variety in allele distribution in this population.
In Silico Analysis of structural and Functional Impact of Non Synonymous SNPs in DC-Sign Receptor Gene
Authors: Muhammad Zubair Mehboob  
Published: November 2024

Background: Cd209 encodes very important trans membrane receptor DC-SIGN in DC and macrophages to recognize and bind with carbohydrate ligands present on surface of pathogen. Structural alterations of this receptor can greatly influence its functions. nsSNPs is important group of SNPs family which brings structural alteration in protein.
Objective: In this study, we sorted out SNPs present in coding region of CD20 and also evaluated their impact of nsSNPs on structure of protein through computational tools.
Methodology: Genomic data has been retrieved from 1000 Genome project and then sorted out by using computational tools including SNpEff, PolyPhen-2, SIFT, PMUT, MutPred, I-Mutant and PROVEAN.
Results: Out of 177 SNPs of coding region, 30 were sorted out as nsSNPs. Among 30 nsSNPs, only 12 nsSNPs have been predicted deleterious.
Conclusion: All pathogenic nsSNPs have been found in Neck and C-lectin damain of receptor which is involved in recognition and binding of ligands. It can be concluded that these nsSNPs can play their role in genetic susceptibility of individuals toward infectious diseases.
Sosialisasi Pembuatan Spray Anti Nyamuk dari Tanaman Serai Wangi dari Tanaman Serai Wangi dalam Pencegahan Penyakit Demam Berdarah di Kampung Long Iram Seberang
Authors: Andriana Nita , Putra Dhimaz Pratama , Belawing Huriansyah , Nissa Indah Khoirun , Al Rasyid Muhammad Fauzan , Janhariyanti  , Cahyani Annisa Dwi , Ngau Florentinus Raynaldi , Hersoyo M Charis Ario , Lestari Ida Ayu Indira Dwika 
Published: November 2024

The Aedes aegypti mosquito is a species of mosquito that is known to be the main factor in the spread of Dengue Hemorrhagic Fever (DHF). This outreach aims to educate about the potential of the citronella plant as a natural mosquito repellent. Citronella (Cymbopogon nardus L.) is a plant that contains essential oils consisting of citronellal (27.87%), citronellol (11.85%), geraniol (22.77%), geranial (14.54%) , neral (11.21%). The citronellol compound contained in citronella essential oil has toxic properties that cause dehydration in animals, especially insects. In the Flagship KKN program Batch 50, KUBAR 12 Group, Mulawarman University innovated in making anti-mosquito spray from citronella plants and provided outreach and carried out direct practice with PKK women in Long Iram Seberang Village, numbering approximately 20 people. The manufacturing process includes drying, cutting, boiling, and mixing with alcohol to maximize the effectiveness of mosquito repellent. The results of this activity show that the resulting spray can last for approximately three days at room temperature and up to seven days if stored in the refrigerator, making it a simple but effective solution in protecting families from mosquito bites. It is hoped that this activity will succeed in increasing public awareness of the importance of maintaining environmental cleanliness and identifying local habits that can naturally reduce the risk of spreading dengue fever
A hybrid model integrating recurrent neural networks and the semi-supervised support vector machine for identification of early student dropout risk
Authors: Nguyen Thi Cam Huong , Sarlan Aliza , Arshad Noreen Izza 
Published: November 2024

Background
Student dropout rates are one of the major concerns of educational institutions because they affect the success and efficacy of them. In order to help students continue their learning and achieve a better future, there is a need to identify the risk of student dropout. However, it is challenging to accurately identify the student dropout risk in the preliminary stages considering the complexities associated with it. This research develops an efficient prediction model using machine learning (ML) and deep learning (DL) techniques for identifying student dropouts in both small and big educational datasets.

Methods
A hybrid prediction model DeepS3VM is designed by integrating a Semi-supervised support vector machine (S3VM) model with a recurrent neural network (RNN) to capture sequential patterns in student dropout prediction. In addition, a personalized recommendation system (PRS) is developed to recommend personalized learning paths for students who are at risk of dropping out. The potential of the DeepS3VM is evaluated with respect to various evaluation metrics and the results are compared with various existing models such as Random Forest (RF), decision tree (DT), XGBoost, artificial neural network (ANN) and convolutional neural network (CNN).

Results
The DeepS3VM model demonstrates outstanding accuracy at 92.54%, surpassing other current models. This confirms the model’s effectiveness in precisely identifying the risk of student dropout. The dataset used for this analysis was obtained from the student management system of a private university in Vietnam and generated from an initial 243 records to a total of one hundred thousand records.
PSENEN influences the progression of renal clear cell carcinoma by regulating the immune microenvironment and oxidative phosphorylation
Authors: Huang Congying , Chen Kaijie , Zhu Siyu , Yang Xin , Hou Jiangang , Gu Xuefeng 
Published: November 2024

Background
Presenilin enhancer gamma-secretase subunit (PSENEN), the straight target of metformin, is highly expressed in several cancers. The role of PSENEN in kidney renal clear cell carcinoma (KIRC) has not been reported.

Methods
PSENEN expression in KIRC specimens was investigated in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, as well as by immunohistochemical analysis and qPCR assay. The relationship between PSENEN expression and patient survival was discussed. The biological function of PSENEN in KIRC and its correlation with immune infiltration of KIRC were then investigated, and possible cellular mechanisms were again analyzed. The effects of metformin on KIRC cell proliferation, migration and invasion were discussed in cellular experiments.

Results
PSENEN was found to be highly expressed in KIRC. The high PSENEN expression was an adverse factor in KIRC. Several immune-related pathways were enriched including immune response, complement and coagulation cascade reactions, and neutrophil extracellular trap formation, as evidenced by enrichment analyses. Immune infiltration analysis revealed that PSENEN expression correlated positively with regulatory T cells. Gene set variation analysis suggested that PSENEN expression correlated positively with oxidative phosphorylation. In addition, a certain concentration of metformin was found to inhibit the proliferation, migration and invasion of KIRC cells, in which PSENEN down-regulation, AMPK up-regulation and mTOR down-regulation were also observed.

Conclusions
PSENEN may be involved in regulating the immune microenvironment of KIRC, and oxidative phosphorylation may also be a pathway for its involvement in cancer development. PSENEN is a novel prognostic marker for KIRC.
Effect of prognostic nutritional index on laboratory parameters and survival in metastatic colorectal cancer patients treated with fruquintinib: a retrospective study
Authors: Wang Zeng , Zhao Sining , Zhang Xuan , Mao Xinyi , Yang Guonong , Yuan Meiqin , Zhou Xiaofang 
Published: November 2024

Objective
Fruquintinib, a novel anti-angiogenic targeted drug, has gained widespread application in the treatment of metastatic colorectal cancer. This study aims to investigate the impact of the prognostic nutritional index (PNI) on the safety and survival outcomes of patients undergoing fruquintinib treatment for metastatic colorectal cancer.

Methods
A cohort of 106 patients with metastatic colorectal cancer, treated with fruquintinib at Zhejiang Cancer Hospital between 2019 and 2023, was included in this study. Clinical and laboratory data were subjected to chi-square and t-tests for analysis. PNI values were calculated using a specific formula. The optimal thresholds (cut-off values) for post-treatment PNI were determined through the ROC curve analysis. Kaplan-Meier analysis and the Log-rank test were employed to evaluate progression-free survival (PFS) and overall survival (OS) based on PNI. Multivariate Cox regression model was used to determine independent prognostic factors which influenced survival time.

Results
The study enrolled 106 colorectal cancer patients treated with fruquintinib. Stratified PNI analysis revealed significant differences in various indicators between high and low PNI groups after treatment with fruquintinib. Notably, after fruquintinib treatment, the high PNI group demonstrated elevated levels in white blood cells, lymphocytes, basophils, red blood cells, hemoglobin, platelets, total protein, and albumin compared to the low PNI group. The median OS for patients with high PNI values was 467 days, significantly longer than the 182 days observed for patients with low PNI values (P < 0.05). Cox regression analysis identified wild-type total RAS and BRAF, partial response (PR) + stable disease (SD), and high PNI values as influencing factors for OS in colorectal cancer patients. Additionally, PR + SD was an independent influencing factor for PFS in colorectal cancer patients (P < 0.05).

Conclusions
This study suggests that fuquinitinib can improve the survival of patients with metastatic colorectal cancer. Patients with high levels of PNI have a better prognosis and longer survival time, ensuring the nutritional status of patients can be a help to improve the treatment of fuquinitinib.
Losartan and dapagliflozin combination therapy in reducing uric acid level compared to monotherapy in patients with heart failure
Authors: Huynh Tuong Le Trong , Pham Phong Thanh , Tran Hien Dieu , Tran Nhan Dinh , Tran Duong Van , Tran Bao Lam Thai , Tran Khoa Dang Dang , Ngo Toan Hoang , Tran Son Kim 
Published: November 2024

Background
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors, and Angiotensin II Receptor Antagonists (ARBs) also have the effect of reducing serum uric acid but few studies worldwide assessed.

Objective
Evaluate the effectiveness of serum uric acid lowering treatment of SGLT2 inhibitors, and ARB in heart failure (HF) patients.

Methods
We conducted a cross-sectional analysis study with 8 weeks of follow-up on 733 heart failure (HF) patients treated at Can Tho Central General Hospital from January 2023 to March 2024. Patients enrolled in the study were examined and received losartan (Group A) or dapagliflozin (Group B) monotherapy or losartan and dapagliflozin combined therapy (Group C). The uric acid concentration group was defined into three subgroups with tertile 1 from smallest to quartile (Q) 1, tertile 2 from Q2 to Q3, and tertile 3 from Q3 to the largest value.

Results
After 8 weeks of treatment, the uric acid reduction effect between groups A, B, and C showed that the combination group had the optimal reducing effect compared to losartan and dapagliflozin monotherapy with the mean difference being −229.62 ± 76.65 µmol/L, −217.00 ± 146.17 µmol/L, and −284.43 ± 136.32 µmol/L, respectively. In total, combination therapy showed the best reduction outcome in the population of male, female, patients with type 2 diabetes mellitus (T2DM), and dyslipidemia with the mean difference ranging from −226.21 ± 74.65 µmol/L to −231.85 ± 76.28 µmol/L and −209.62 ± 184.94 µmol/L to −225.75 ± 78.53 µmol/L and −273.02 ± 204.54 µmol/L to −308.93 ± 72.97 µmol/L in group A, B, and C, respectively.

Conclusion
The optimal therapy for reducing uric acid levels in HF patients was the combination of losartan and dapagliflozin, and the effectiveness did not change through sex, T2DM, and dyslipidemia patients.