bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing Students’ Mental Health in a ‘Sustainable Societies’ Class
Authors: Godfrey Phoebe Christina , Frechette Julianne , Larkin-Wells Jessica 
Published: December 2018

On an average college campus, about 41.6 percent of students are suffering from anxiety and 36.4 percent from depression. We do not think we can address student’s mental health challenges without also talking about power/oppression in the classroom. What we present here is a case study of our attempts at intersectional compassionate pedagogy (ICP) that focused on creating authentic intimate connections and community as our pedagogy.
I, Phoebe, teach a sociology class, ‘Sustainable Societies’ for which I decided that there can be no ‘sustainability’ if a large percentage of students in the class is suffering from some form of mental distress. As a means of putting the wellbeing of my students at the central focus of the class, I recruited three former students to work with me as student mentors.
I, Jess, and the two other mentors modeled social sustainability by sharing leadership of the class. We explored in particular the power dynamics entrenched in positionality of race, class, gender, age and sexuality. We further intended to radically challenge the culture of isolation and disengagement on campus and demonstrate the potential for healing within the classroom by prioritising healthy and connected relationships between all members of the class.
I, Julianne was a student in this class, I saw myself, and peers begin to re-harness our natural willingness to self-express. The challenge was to shift our internal framework to one of connection to ourselves and eventually each other, in order to create a sustainable society for all.
We collectively believe that educators have a responsibly to challenge the oppression inherent in our current school system through creative pedagogy. This lofty aim requires thinking flexibly about what a successful education looks like. This is our story.
Produção de textos escritos na alfabetização: Um estudo em duas escolas públicas localizadas em territórios socialmente vulneráveis
Authors: Fonseca Gleice Lima da , Vóvio Claudia Lemos 
Published: December 2018

Este artigo analisa o ensino da escrita de textos na alfabetização, em duas escolas municipais paulistas, localizadas em territórios socialmente vulneráveis. Apesar de um estudo predominantemente qualitativo, adotou-se os métodos mistos, com a intenção de fazer convergir diferentes fontes e reunir procedimentos diversificados de análise. Nesse sentido, reúnem-se a análise de fonte documental, de cadernos escolares e de registros de observação participante de aulas de Língua Portuguesa em sete turmas de terceiro ano do Ensino Fundamental, durante o ano letivo de 2014, focalizando as tarefas e escritas de textos de alunos. As categorias analíticas empregadas advêm da exploração dos dados e do estudo das atualizações e mudanças teórico-metodológicas observadas na alfabetização e na organização curricular nessa rede de ensino. Os resultados obtidos demonstram disparidades entre o que se ensina nessas escolas e os conteúdos e as oportunidades previstos para as escolas municipais paulistas. Além da baixa frequência com que realizam tarefas de escrita de textos, as disparidades observadas dizem respeito à seleção de conteúdos e à adoção de abordagens divergentes daquelas preconizadas no documento curricular oficialmente estabelecido. Tendo em vista o que a literatura aponta sobre a distribuição de conhecimento escolar, no sentido de que alunos provenientes de meios sociais desfavorecidos apresentam desvantagens, os resultados apontam para desigualdades quanto ao acesso a conhecimentos e à aquisição de capacidades relativas à escrita de textos, o que torna mais complexo o enfrentamento das desigualdades educacionais para determinados grupos.
KONTRIBUSI PENELITIAN FILOLOGI TERHADAP PERKEMBANGAN STUDI KEISLAMAN
Authors: Ibrahim Arif , Kosasih Ade , Ma'mun Titin Nurhayati , Darsa Undang Ahmad 
Published: December 2018

Artikel ini berjudul“Kontribusi Penelitian Filologi Terhadap Pengembangan Studi Keislaman”Penelitian ini menggunakan metode deskriptif analitik dan bertujuan untuk mengungkap kegunaan sebuah penelitian filologi yang bernaskah islami terhadap perkembangan studi keislaman Nusantara. Ruang lingkup penelitian ini adalah kontribusi naskah-naskah lama islami terhadap studi keislaman saat ini. Penulis menampilkan tiga penelitian yang membuktikan kontribusi filologi terhadap studi keislaman, diantaranya disertasi Syarah Nashaihul ‘Ibad di Banten dan dua tesis yaitu naskah fiqih sunda islami di Kuningan dan Naskah At-Tariqah Al-Wadihah Ila Asrari Al-Fatihah tentang tafsir surat Al-Fatihah.AbstractThis article titled "The Contribution of Philology Research to the Development of Islamic Studies" This research uses descriptive analytic method and its aim is revealing the usefulness of a philology research with Islamic manuscriptfor theislamic studiesdevelopment of the archipelago. The scope of this study is the contribution of old Islamic manuscripts for modern Islamic studies. The author presents three research that prove the philology's contribution for Islamic studies, they are the dissertation of Syarah Nashoihul 'Ibad in Banten and two theses namely Fiqih script of Sunda Islami in Kuningan and the At-Tariqah Al-Wadihah Ila Asrari Al-Fatihah's Text of Al-Fatihah.
Feed quantitative restriction and coenzyme Q10 level on performance, plasma lipoproteins and organ weights of broiler chicks
Authors: Jahanpour H. , Chamani M. , Seidavi A.R. , Sadeghi A.A. , Amin-Afshar M. 
Published: December 2018

An experiment was conduct in order to investigate the effects of feed restriction level and duration and dietary coenzyme Q10 level on growth performance, organ characteristics and plasma lipoproteins. A factorial arangment based on a completely randomized design was performed using two levels of feed restriction (10 and 20% less than the standard Ross strain 308 guidelines), two levels of restriction duration (7 and 14 days) and three levels of coenzyme Q10 (0, 20 and 40 mg/kg feed). The results of the experiment showed that restriction intensity had significant effect on feed intake in first, second and sixth weeks of age (P<0.05), body weight gain in second and sixth weeks of age (P<0.05), and feed conversion ratio in first week of age (P<0.05). Restriction duration had significant effect on feed intake in third week of age (P<0.05), and feed conversion ratio in third and sixth weeks of age (P<0.05). Coenzyme Q level had significant effect on feed intake in first and sixth weeks of age (P<0.05), body weight gain in second, fifth and sixth weeks of age (P<0.05), and feed conversion ratio in second and sixth weeks of age (P<0.05). In conclusion, considering the positive effects of feed restriction and coenzyme Q10 on broiler yield, the simaltaneous use of feed restriction strategy and dietary coenzyme Q10 can be considered as a management program in order to improvement of broiler productivity.
Determinants of technical efficiency in duck production in southwest Nigeria
Authors: Baruwa Olayinka Isiaka , Tijani Akeem Abiade , Alimi Taiwo 
Published: December 2018

Abstract
The need to complement the supply of animal products with other sources of poultry necessitates exploring the potentials of domestic duck production. Studies conducted on indigenous ducks in Nigeria have paid less attention to the resource requirements and its determinants to duck production. This study therefore estimated technical efficiencies of domestic duck producers in South-western Nigeria, and identified some socio-economic factors, which influence them. A combination of purposive and random sampling was employed. Stochastic frontier production function approach using a translog production function was used to estimate the technical efficiencies of indigenous duck producers, while inefficiency model was used to determine the socio-economic factors affecting the technical efficiencies. The results showed that the level of technical efficiency ranged from 48% to 96% with a mean of 83.3%, which suggests that average duck output was 16.7% short of the maximum possible level. This implies that productive efficiency could still be improved using the subsisting resource base. The study concluded that mounting capacity building programmes for duck farmers generally, and availability of credit could increase the productivity of duck enterprise if monitored.
In vitro response of three contrasting cassava (Manihot esculenta Crantz) varieties to mannitol-induced drought stress
Authors: Jolayemi Okanlawon Lekan , Opabode Jelili Titilola , Badara Gueye 
Published: December 2018

Abstract
In vitro selection of drought-tolerant cassava varieties is essential for rapid breeding for drought tolerance. The objectives of this study were to determine the response of three contrasting cassava varieties to mannitol-induced drought stress to establish its suitability for in vitro screening and examine relationships among growth parameters. Plantlets were raised from nodal segments on Murashige and Skoog (MS) medium containing 0 (control), 5, 10, 15, 20, 25 and 30 g/l mannitol. Variety CH 140 had the highest survival of explants and frequency of root formation, while MV 99/0395 recorded the highest number of chlorotic leaves and the lowest survival of explants. The lowest numbers of leaves were produced at 25 and 30 g/l mannitol by the three varieties. In CH 140, the highest number of leaves was produced in medium free of mannitol, while the highest number of leaves was produced at 5 and 10 g/l mannitol in MV 99/0395 and TMS 01/1206, respectively. In TMS 01/1206, number of roots produced decreased as the concentration of mannitol in culture media increased, whereas in CH140, number of roots increased as the concentration of mannitol increased before decreasing; while in MV 99/0395, number of roots was not affected by an increase in mannitol concentration. As the concentration of mannitol in the culture media increased shoot height of plantlets decreased with a sharp decline at 20 mg/l mannitol. Concentration of mannitol and survival of explants had significant negative correlation with all parameters. However, frequency of root formation only had significant positive correlation with shoot length. The study concluded that differential responses were expressed by the three varieties to mannitol-induced drought stress and mannitol at 20 g/l concentration was a suitable in vitro drought inducing-agent for screening cassava varieties for drought tolerance.
Spontaneously remitting insulin autoimmune syndrome in a patient taking alpha-lipoic acid
Authors: Cappellani D , Sardella C , Campopiano M C , Falorni A , Marchetti P , Macchia E 
Published: December 2018

SummaryInsulin autoimmune syndrome (IAS), or Hirata disease, is a rare hypoglycaemic disorder caused by the presence of high titer of insulin autoantibodies (IAA) in patients without previous exposure to exogenous insulin. Even though its pathogenesis is not fully understood, striking evidences link IAS to previous exposure to sulphydryl-containing medications, like alpha-lipoic acid, a widely used nutritional supplement. Although challenging, a careful differential diagnosis from other causes of hyperinsulinaemic hypoglycaemia (such as insulinoma) is mandatory, since these conditions require different therapeutic approaches. In the present study, we report a 35-year-old woman originally from Sri Lanka who was referred to our University Hospital on suspicion of occult insulinoma. Her medical history was positive for endometriosis, treated with estroprogestins and alpha-lipoic acid. The latter supplement was begun 2 weeks before the first hypoglycaemic episode. Our tests confirmed the presence of hypoglycaemia associated with high insulin and C-peptide concentrations. When insulin concentrations were compared using different assays, the results were significantly different. Moreover, insulin values significantly decreased after precipitation with polyethylene glycol. An assay for IAA proved positive (530 U/mL). A genetic analysis revealed the presence of HLA-DRB1*04,15, an immunogenetic determinant associated with IAS. On the basis of clinical data we avoided a first-line approach with immunosuppressive treatments, and the patient was advised to modify her diet, with the introduction of frequent low-caloric meals. During follow-up evaluations, glucose levels (registered trough a flash glucose monitoring system) resulted progressively more stable. IAA titer progressively decreased, being undetectable by the fifteenth month, thus indicating the remission of the IAS.Learning points:Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinaemic hypoglycaemia, whose prevalence is higher in East Asian populations due to the higher prevalence of specific immunogenetic determinants. Nevertheless, an increasing number of IAS cases is being reported worldwide, due to the wide diffusion of medications such as alpha-lipoic acid.Differential diagnosis of IAS from other causes of hyperinsulinemic hypoglycaemia is challenging. Even though many tests can be suggestive of IAS, the gold standard remains the detection of IAAs, despite that dedicated commercial kits are not widely available.The therapeutic approach to IAS is problematic. As a matter of fact IAS is often a self-remitting disease, but sometimes needs aggressive immunosuppression. The benefits and risks of any therapeutic choice should be carefully weighted and tailored on the single patient.
MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post hoc analysis
Authors: Bonneville Fabrice , Rivière Louis-David , Petersenn Stephan , Bevan John S , Houchard Aude , Sert Caroline , Caron Philippe J , _ _ , _ _ , Van Gaal L , Marek J , Nuutila P , Välimäki M , Ajzenberg C , Borson-Chazot F , Brue T , Caron P , Chabre O , Chanson P , Rudelli C Cortet , Delemer B , Kuhn J-M , Tabarin A , Badenhoop K , Berg C , Petersenn S , Schöfl C , Schopohl J , Cannavò S , Colao A , De Marinis L , Stades A , van der Lely A J , Kadıoğlu P , Bevan J S , Flanagan D , Trainer P 
Published: December 2018

Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA.

Design Post hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120 mg) every 4 weeks for 48 weeks.

Methods Associations were investigated between adenoma T2-signal hypo/iso/hyperintensity and treatment responses at week 48/last visit: hormonal control (GH ≤2.5 μg/L and IGF-1 normalization); tumor response (tumor volume reduction (TVR) ≥20%); separate GH/IGF-1 control and change from baseline in GH/IGF-1 and tumor volume.

Results Adenomas were hypointense at baseline in 50/85 (59%) patients using visual assessment. Of these, 40% achieved hormonal control and 76% achieved a tumor response. Significant univariate associations arose for hypo- vs isointensity with tumor response and achievement of GH ≤2.5 μg/L, but not IGF-1 normalization or overall hormonal control. In multivariate analysis, tumor response was six times more likely for hypo- vs iso-intense tumors (= 6.15; 95% CI: 1.36–27.88). In univariate change-from-baseline analyses, hypo- vs isointensity was associated with greater TVR and IGF-1 reduction but not change in GH. In multivariate analysis, IGF-1 decreased by an estimated additional 65 μg/L (P = 0.0026)) for hypo- vs isointense.

Conclusions Patients with hypointense vs isointense GH-secreting macroadenomas had greater reductions in IGF-1 following primary treatment with lanreotide autogel and were more likely to achieve tumor response. Assessment of T2 signal intensity at baseline may help to predict long-term responses to primary treatment with SSAs.
Paired surveys for patients and physiologists in echocardiography: a single-centre experience
Authors: Roshen Michael , John Sophia , Ahmet Selda , Amersey Rajiv , Gupta Sandy , Collins George 
Published: December 2018

Abstract
The British Society of Echocardiography (BSE) highlights the importance of patient questionnaires as part of the quality improvement process, To this end, we implemented a novel system whereby paired surveys were completed by patients and physiologists for transthoracic echocardiography scans, allowing for parallel comparison of the experiences of service providers and end users. Anonymised questionnaires were completed for each scan by the patient and physiologist for outpatient echocardiographic scans in a teaching hospital. In 26% of the responses, patient found the scans at least slightly painful, and in 24% of scans physiologists were in discomfort. The most common reason given by physiologists for technically difficult or inadequate scans was patient discomfort. In 38% of the scans at least one person (the patient or the physiologist) was in at least some discomfort. Comparative data showed that the scans reported as most painful by patients were also reported by the physiologists as difficult and uncomfortable. In summary, these results demonstrate the feasibility of implementing paired surveys. Patient information leaflets by the BSE and National Health Service (NHS) describe echocardiography as painless but the results here indicate this is not always the case.
Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression
Authors: Bush Stephen J , McCulloch Mary E B , Muriuki Charity , Salavati Mazdak , Davis Gemma M , Farquhar Iseabail L , Lisowski Zofia M , Archibald Alan L , Hume David A , Clark Emily L 
Published: December 2018

Abstract
One of the most significant physiological challenges to neonatal and juvenile ruminants is the development and establishment of the rumen. Using a subset of RNA-Seq data from our high-resolution atlas of gene expression in sheep (Ovis aries) we have provided the first comprehensive characterization of transcription of the entire gastrointestinal (GI) tract during the transition from pre-ruminant to ruminant. The dataset comprises 164 tissue samples from sheep at four different time points (birth, one week, 8 weeks and adult). Using network cluster analysis we illustrate how the complexity of the GI tract is reflected in tissue- and developmental stage-specific differences in gene expression. The most significant transcriptional differences between neonatal and adult sheep were observed in the rumen complex. Comparative analysis of gene expression in three GI tract tissues from age-matched sheep and goats revealed species-specific differences in genes involved in immunity and metabolism. This study improves our understanding of the transcriptomic mechanisms involved in the transition from pre-ruminant to ruminant by identifying key genes involved in immunity, microbe recognition and metabolism. The results form a basis for future studies linking gene expression with microbial colonization of the developing GI tract and provide a foundation to improve ruminant efficiency and productivity through identifying potential targets for novel therapeutics and gene editing.
A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting inDrosophilaFollicular Somatic Cells
Authors: Martins Nelson , Lemoine Aurélie , Santiago Estelle , Paro Simona , Imler Jean-Luc , Meignin Carine 
Published: December 2018

AbstractThe small interfering RNA (siRNA) pathway is the main and best studied invertebrate antiviral response. Other poorly characterized protein based antiviral mechanisms also contribute to the control of viral replication in insects. In addition, it remains unclear whether tissue specific factors contribute to RNA and protein-based antiviral immunity mechanisms. In vivo screens to identify such factors are challenging and time consuming. In addition, the scored phenotype is usually limited to survival and/or viral load. Transgenic viral replicons are valuable tools to overcome these limitations and screen for novel antiviral factors. Here we describe transgenic Drosophila melanogaster lines encoding a Flock House Virus-derived replicon (FHV∆B2eGFP), expressing GFP as a reporter of viral replication. This replicon is efficiently controlled by the siRNA pathway in most somatic tissues, with GFP fluorescence providing a reliable marker for the activity of antiviral RNAi. Interestingly, in follicular somatic cells (FSC) of ovaries, this replicon is still partially repressed in an siRNA independent manner. We did not detect replicon derived Piwi-interacting RNAs in FSCs and identified 31 differentially expressed genes between restrictive and permissive FSCs. Altogether, our results uncovered a yet unidentified RNAi-independent mechanism controlling FHV replication in FSCs of ovaries and validate the FHV∆B2eGFP replicon as a tool to screen for novel tissue specific antiviral mechanisms.
Optimizing Genomic Selection for a Sorghum Breeding Program in Haiti: A Simulation Study
Authors: Muleta Kebede T , Pressoir Gael , Morris Geoffrey P 
Published: December 2018

AbstractYoung breeding programs in developing countries, like the Chibas sorghum breeding program in Haiti, face the challenge of increasing genetic gain with limited resources. Implementing genomic selection (GS) could increase genetic gain, but optimization of GS is needed to account for these programs’ unique challenges and advantages. Here, we used simulations to identify conditions under which genomic-assisted recurrent selection (GARS) would be more effective than phenotypic recurrent selection (PRS) in small new breeding programs. We compared genetic gain, cost per unit gain, genetic variance, and prediction accuracy of GARS (two or three cycles per year) vs. PRS (one cycle per year) assuming various breeding population sizes and trait genetic architectures. For oligogenic architecture, the maximum relative genetic gain advantage of GARS over PRS was 12–88%, which was observed only during the first few cycles. For the polygenic architecture, GARS provided maximum relative genetic gain advantage of 26–165%, and was always superior to PRS. Average prediction accuracy declines substantially after several cycles of selection, suggesting the prediction models should be updated regularly. Updating prediction models every year increased the genetic gain by up to 33–39% compared to no-update scenarios. For small populations and oligogenic traits, cost per unit gain was lower in PRS than GARS. However, with larger populations and polygenic traits cost per unit gain was up to 67% lower in GARS than PRS. Collectively, the simulations suggest that GARS could increase the genetic gain in small young breeding programs by accelerating the breeding cycles and enabling evaluation of larger populations.