bluuebunny/crossref_metadata_2025_split huggingface dataset:
Escola consumada e consumida: o declínio da política na contemporaneidade e seus efeitos sobre a escola
Authors: Batista Douglas Emiliano 
Published: August 2019

Este artigo procura distinguir o dispositivo escolar que foi hegemônico na modernidade daquele que é hegemônico na contemporaneidade: enquanto o primeiro era indissociável do ressurgimento da política nos primórdios dos tempos modernos, o segundo o é do declínio da política – e da consequente ascensão da tecnoburocracia e da tecnociência – nas últimas décadas do século XX. Nesses termos, o dispositivo escolar hegemônico na contemporaneidade vem sendo consumido para melhor se consumar, o que significa que a escola admitida hoje como ideal é a que se faz onipresente (consumada) na proporção em que é também radicalmente desescolarizada (consumida). Trata-se de dessimbolizar a escola (no que concerne, por exemplo, à transferência do aluno ao professor) para adequá-la aos imperativos visados pela tecnoburocracia e pelo mercado nos termos aparentemente democráticos do gozo de uma inclusão total. Desse modo, o dispositivo escolar acaba sendo consumido e consumado na medida em que seu objetivo já não é tanto formar sujeitos e cidadãos do Estado-Nação, mas conformar indivíduos e consumidores de um mundo global.
Palavras-chave: dispositivo escolar moderno; dispositivo escolar contemporâneo; declínio da política; dessimbolização da escola contemporânea.
Post–Myocardial Infarction Scar With Fat Deposition Shows Specific Electrophysiological Properties and Worse Outcome After Ventricular Tachycardia Ablation
Authors: Cheniti Ghassen , Sridi Soumaya , Sacher Frederic , Chaumeil Arnaud , Pillois Xavier , Takigawa Masateru , Frontera Antonio , Vlachos Konstantinos , Martin Claire A. , Teijeira Elvis , Kitamura Takeshi , Lam Anna , Bourier Felix , Puyo Stephane , Duchateau Josselin , Denis Arnaud , Pambrun Thomas , Chauvel Remi , Derval Nicolas , Laurent François , Montaudon Michel , Hocini Meleze , Haissaguerre Michel , Jais Pierre , Cochet Hubert 
Published: August 2019

Background

Fat deposition (
FD
) is part of the healing process after myocardial infarction. The characteristics of
FD
and its impact on the outcome in patients undergoing ventricular tachycardia (
VT
) ablation have not been thoroughly studied.

Methods and Results

We studied consecutive patients undergoing post–myocardial infarction
VT
ablation with pre‐procedural cardiac computed tomography.
FD
was defined as intra‐myocardial attenuation ≤ −30
HU
on computed tomography. Clinical, anatomical, and post‐procedural outcome was assessed in the overall population. Electrophysiological characteristics were assessed is a subgroup of patients with high‐density electro‐anatomical maps. Sixty‐nine patients were included (66±12 years).
FD
was detected in 44 (64%) patients. The presence of
FD
related to scar age (odds ratio [OR]: 1.14 per year;
P
=0.001) and scar extent (
OR
: 1.27 per segment;
P
=0.02). On electro‐anatomical maps,
FD
was characterized by lower bipolar amplitude (
P
<0.001) and prolonged electrogram duration (
P
<0.001). Although the proportion of local abnormal ventricular activation was similar (
P
=0.22), local abnormal ventricular activation showed lower amplitude (
P
<0.001) and were more delayed (
P
<0.001) in scars with
FD
. After a mean follow‐up of 26 months, patients with
FD
experienced a worse outcome including all‐cause mortality and
VT
recurrence (70% versus 28%,
P
log rank=0.009). On multivariate analysis,
FD
(hazard ratio=2.69; 95%
CI
, 1.12–6.46;
P
=0.027) and left ventricular systolic dysfunction (hazard ratio=2.57; 95%
CI
, 1.13–5.85;
P
=0.024) were independent predictors of adverse outcomes.

Conclusions

FD
in patients with post–myocardial infarction
VT
undergoing catheter ablation relates to scar age and size and may be a marker of adverse outcomes including all‐cause mortality and
VT
recurrence.
Local Atmosphere–Ocean Predictability: Dynamical Origins, Lead Times, and Seasonality
Authors: Bach Eviatar , Motesharrei Safa , Kalnay Eugenia , Ruiz-Barradas Alfredo 
Published: August 2019

AbstractDue to the physical coupling between atmosphere and ocean, information about the ocean helps to better predict the future of the atmosphere, and in turn, information about the atmosphere helps to better predict the ocean. Here, we investigate the spatial and temporal nature of this predictability: where, for how long, and at what frequencies does the ocean significantly improve prediction of the atmosphere, and vice versa? We apply Granger causality, a statistical test to measure whether a variable improves prediction of another, to local time series of sea surface temperature (SST) and low-level atmospheric variables. We calculate the detailed spatial structure of the atmosphere-to-ocean and ocean-to-atmosphere predictability. We find that the atmosphere improves prediction of the ocean most in the extratropics, especially in regions of large SST gradients. This atmosphere-to-ocean predictability is weaker but longer-lived in the tropics, where it can last for several months in some regions. On the other hand, the ocean improves prediction of the atmosphere most significantly in the tropics, where this predictability lasts for months to over a year. However, we find a robust signature of the ocean on the atmosphere almost everywhere in the extratropics, an influence that has been difficult to demonstrate with model studies. We find that both the atmosphere-to-ocean and ocean-to-atmosphere predictability are maximal at low frequencies, and both are larger in the summer hemisphere. The patterns we observe generally agree with dynamical understanding and the results of the Kalnay dynamical rule, which diagnoses the direction of forcing between the atmosphere and ocean by considering the local phase relationship between simultaneous sea surface temperature and vorticity anomaly signals. We discuss applications to coupled data assimilation.
Variability of Sea Level and Upper-Ocean Heat Content in the Indian Ocean: Effects of Subtropical Indian Ocean Dipole and ENSO
Authors: Zhang Lei , Han Weiqing , Li Yuanlong , Lovenduski Nicole S. 
Published: August 2019

Abstract
In this study, the Indian Ocean upper-ocean variability associated with the subtropical Indian Ocean dipole (SIOD) is investigated. We find that the SIOD is associated with a prominent southwest–northeast sea level anomaly (SLA) dipole over the western-central south Indian Ocean, with the north pole located in the Seychelles–Chagos thermocline ridge (SCTR) and the south pole at southeast of Madagascar, which is different from the distribution of the sea surface temperature anomaly (SSTA). While the thermocline depth and upper-ocean heat content anomalies mirror SLAs, the air–sea CO2 flux anomalies associated with SIOD are controlled by SSTA. In the SCTR region, the westward propagation of oceanic Rossby waves generated by anomalous winds over the eastern tropical Indian Ocean is the major cause for the SLAs, with cyclonic wind causing negative SLAs during positive SIOD (pSIOD). Local wind forcing is the primary driver for the SLAs southeast of Madagascar, with anticyclonic winds causing positive SLAs. Since the SIOD is correlated with ENSO, the relative roles of the SIOD and ENSO are examined. We find that while ENSO can induce significant SLAs in the SCTR region through an atmospheric bridge, it has negligible impact on the SLA to the southeast of Madagascar. By contrast, the SIOD with ENSO influence removed is associated with an opposite SLA in the SCTR and southeast of Madagascar, corresponding to the SLA dipole identified above. A new subtropical dipole mode index (SDMI) is proposed, which is uncorrelated with ENSO and thus better represents the pure SIOD effect.
miR-16 regulates proliferation and invasion of lung cancer cells via the ERK/MAPK signaling pathway by targeted inhibition of MAPK kinase 1 (MEK1)
Authors: Chen TianMing , Xiao Qi , Wang XiaoJun , Wang ZhongQiu , Hu JingWen , Zhang Zhi , Gong ZhuNan , Chen ShiLin 
Published: August 2019

Objective The ERK/MAPK signaling pathway regulates cell proliferation and invasion. MAPK kinase 1 (MEK1) is a protein kinase upstream of ERK that can activate the pathway. Expression of microRNA (miR)-16 in lung cancer tissues is decreased. The aim of this study was to determine roles of miR-16 in proliferation and invasion of lung cancer cells. Methods We used a luciferase reporter assay to determine a regulatory relationship between miR-16 and MEK1 and assessed expression of MEK1 in normal lung cells and lung cancer cell lines. Plate cloning, flow cytometry, and Transwell experiments demonstrated the proliferation and invasion ability of cells transfected with wild-type and mutant MEK1. Results We confirmed a regulatory relationship between miR-16 and MEK1 mRNA. Expression of miR-16 was decreased and that of MEK1 and p-ERK1/2 were increased in lung cancer cell lines compared with normal cells. Transfection with miR-101 mimic or small interfering (si)-MEK1 significantly downregulated expression of MEK1 and p-ERK1/2 in Anip973 cells. Conclusions Decreased miR-16 expression may play a role in upregulating expression of MEK1 and promoting proliferation and invasion of lung cancer cells. Overexpression of miR-16 downregulated the ERK/MAPK pathway by inhibiting MEK1 expression, attenuating clone formation and invasion, and inhibiting cell proliferation.
Follicular output rate tends to improve clinical pregnancy outcomes in patients with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer treatment
Authors: Tan Xiaoqing , Wen Yu , Chen Huixiao , Zhang Ling , Wang Bin , Wen Hongwei , Zhang Fengli , Wu Qin , Du Jing 
Published: August 2019

Objective This study aimed to examine the relationship between the follicular output rate (FORT) and clinical outcomes in patients with polycystic ovarian syndrome (PCOS). Methods A total of 841 patients with PCOS undergoing in vitro fertilization-embryo transfer (IVF-ET) were divided into three groups according to their FORT (low, middle, and high). Controlled ovarian hyperstimulation and clinical outcomes were compared retrospectively. Results Serum estradiol levels on the day of human chorionic gonadotropin (3780.5, 3599.9, and 3375.7 pg/mL) and the number of retrieved oocytes (17.5, 16.1, and 14.8) decreased from the high to low FORT groups. Pre-ovulatory follicle counts were significantly higher in the high FORT group than in the middle and low FORT groups. The number of retrieved oocytes, high-quality embryo rate, and clinical pregnancy rate decreased from the high to low FORT groups. The incidence of moderate and severe ovarian hyperstimulation syndrome (OHSS) in the middle FORT group was significantly lower than that in the high and low FORT groups. Conclusions FORT may be used to predict clinical outcomes of IVF/intracytoplasmic sperm injection-embryo transfer in patients with PCOS. Efforts should be made to prevent OHSS in patients with PCOS and a high or low FORT in controlled ovarian hyperstimulation cycles.
Resection of mesothelial cyst of uterine round ligament by laparoscopic transabdominal preperitoneal procedure alone or combined with open surgery
Authors: Chen Dongfeng , Zhang Pan , Zhang Haifeng , Guo Mingxiao , Wang Weijia , Zhang Zhaoyong 
Published: August 2019

Objective Surgical treatment of a mesothelial cyst of the uterine round ligament (MCURL), an uncommon entity, has been rarely documented. In this article, we present our experience with excision of MCURLs. Methods The records of all female patients undergoing surgical removal of a groin mass in our department from March 2013 to November 2018 were retrospectively reviewed. Demographic information, clinical data, and follow-up outcomes were collected and analyzed. Results Among 298 women who underwent groin hernia repair, 17 (5.7%) had MCURLs. Of these 17 patients, 13 were aged 30 to 45 years and 15 had a normal body mass index (18.5–23.9 kg/m2). MCURLs occurred predominantly on the right side (11/17). Approximately half of the patients (9/17) were preoperatively misdiagnosed with inguinal hernias. Approximately 70% (12/17) of the lesions were localized medially to the inner ring of the inguinal canal and excised by a laparoscopic transabdominal preperitoneal (TAPP) procedure alone. Five patients required open surgery following the TAPP procedure because the cyst extended distally beyond the inner ring. No recurrence was noted during the entire follow-up period. Conclusion Most MCURLs were localized medially to the inner ring of the inguinal canal and could be excised by a TAPP procedure.
Low-Profile Dual Small Plate Fixation Is Biomechanically Similar to Larger Superior or Anteroinferior Single Plate Fixation of Midshaft Clavicle Fractures
Authors: Ziegler Connor G. , Aman Zachary S. , Storaci Hunter W. , Finch Hannah , Dornan Grant J. , Kennedy Mitchell I. , Provencher Matthew T. , Hackett Thomas R. 
Published: August 2019

Background: Limited biomechanical data exist for dual small plate fixation of midshaft clavicle fractures, and no prior study has concurrently compared dual small plating to larger superior or anteroinferior single plate and screw constructs. Purpose: To biomechanically compare dual small orthogonal plating, superior plating, and anteroinferior plating of midshaft clavicle fractures by use of a cadaveric model. Study Design: Descriptive laboratory study. Methods: The study used 18 cadaveric clavicle specimens (9 pairs total), and 3 plating techniques were studied: anteroinferior, superior, and dual. The dual plating technique used smaller diameter plates and screws (1.6-mm thickness) than the other, single plate techniques (3.3-mm thickness). Each of the 9 clavicle pairs was randomly assigned a combination of 2 plating techniques, and randomization was used to determine which techniques were used for the right and left specimens. Clavicles were plated and then osteotomized to create an inferior butterfly fracture model, which was then fixed with a single interfragmentary screw. Clavicle specimens were then potted for mechanical testing. Initial bending, axial, and torsional stiffness of each construct was determined through use of a randomized nondestructive cyclic testing protocol followed by load to failure. Results: No significant differences were found in cyclical axial ( P = .667) or torsional ( P = .526) stiffness between plating groups. Anteroinferior plating demonstrated significantly higher cyclical bending stiffness than superior plating ( P = .005). No significant difference was found in bending stiffness between dual plating and either anteroinferior ( P = .129) or superior plating ( P = .067). No significant difference was noted in load to failure among plating methods ( P = .353). Conclusion: Dual plating with a smaller plate-screw construct is biomechanically similar to superior and anteroinferior single plate fixation that uses larger plate-screw constructs. No significant differences were found between dual plating and either superior or anteroinferior single plating in axial, bending, or torsional stiffness or in bending load to failure. Dual small plating is a viable option for fixing midshaft clavicle fractures and may be a useful low-profile technique that avoids a larger and more prominent plate-screw construct. Clinical Relevance: Plate prominence and hardware irritation are commonly reported complaints and reasons for revision surgery after plate fixation of midshaft clavicle fractures. Dual small plate fixation has been used to improve cosmetic acceptability, minimize hardware irritation, and decrease reoperation rate. Biomechanically, dual small plate fixation performed similarly to larger single plate fixation in this cadaveric model of butterfly fracture.
Digitisation as a Contingent Factor in India’s Financial Sector Development-growth Nexus: An Empirical Study
Authors: Jayaraman T. K. , Makun Keshmeer 
Published: August 2019

Financial sector development (FSD) has been recognised as a supportive factor, acting as a shift variable in the growth function, besides the fundamental variables of capital stock and labour. Since the beginning of the new millennium, rapid strides in the spread of information and communication technology (ICT) have enabled the hitherto reluctant, urban-based banking institutions to reach the rural masses for mobilising savings. Digitisation through various innovations has made it possible that ‘brick and mortar less’ bank branches now increasingly provide financial services to rural India. This study examines the role of digitisation as a contingent factor in India’s FSD and growth nexus during the last 13 years (2003–2015). The findings of the empirical study through employment of ARDL methodology and application of bounds testing procedure by utilising 52 quarterly observations of the data series of relevant variables reveal that digitisation has indeed emerged a significant factor in the FSD and growth nexus, by playing a complementary role to FSD. There are two policy implications: (a) as ICT has emerged a major tool, it has to be supported at all levels, and (b) the financial inclusion process should be carried forward as it has all the potential to speed up economic growth and development. JEL: G21, O16, O33
The effect of tea tree oil on dry eye treatment after phacoemulsification cataract surgery: A randomized clinical trial
Authors: Mohammadpour Mehrdad , Maleki Siamak , Khorrami-Nejad Masoud 
Published: August 2019

Purpose: To evaluate the effect of eyelid scrubbing with eye shampoo containing tea tree oil on dry eye disease following phacoemulsification cataract surgery. Methods: This prospective triple-blinded randomized clinical trial was performed on 62 eyes of 62 patients. Patients were randomly assigned to two groups—(1) treatment group: for 33 patients in the treatment group, artificial tears, topical steroid drops, and eye shampoos with tea tree oil and (2) for 29 patients in the control group, artificial tears, topical steroids, and eye shampoos without tea tree oil were used. In the first and second (after 1 month) follow-up visits, microscopic Demodex examination, refraction, corrected distance visual acuity, the ocular surface disease index score (by the questionnaire), Schirmer test, tear break-up time test, and osmolarity of tears (by TearLab) were recorded in treatment and control groups. Results: The mean age of patients was 66.37 ± 8.83 (range: 37–82) years, of which 49 (79%) were female and 13 (21%) were male. The results showed a significant improvement in tear break-up time test, corrected distance visual acuity, osmolarity, and ocular surface disease index score in both groups ( p < 0.05). However, the number of Demodex decreases significantly only in the treatment group after treatment ( p <0.001). Tear break-up time, osmolarity, and ocular surface disease index scores in the treatment group were significantly better than the control group ( p < 0.05). However, there was no significant difference between the two groups in the pre- and post-Schirmer test results ( p > 0.05). Conclusion: Eyelid scrubbing with eye shampoo containing tea tree oil is recommended for dry eye treatment after cataract surgery, especially decrease in the number of Demodex.
HLA-B*58:01 Genotyping to Prevent Cases of DRESS and SJS/TEN in East Asians Treated with Allopurinol—A Canadian Missed Opportunity
Authors: Ponzo Marisa Grace , Miliszewski Monica , Kirchhof Mark G. , Keown Paul A. , Dutz Jan P. 
Published: August 2019

Background and objective East Asians exposed to the urate-lowering drug allopurinol have a predilection for severe cutaneous drug reactions such as drug-induced hypersensitivity syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Screening is recommended in patients of East Asian descent for the presence of HLA-B*58:01 prior to allopurinol initiation to avoid these complications. Utilization rates of the HLA-B*58:01 predictive screening test within the Greater Vancouver area, which has a population composed of 40.1% people of East Asian descent, are unknown. Measures We identified cases of DRESS or SJS/TEN due to allopurinol using the Vancouver General Hospital dermatology consult service database. We next compared the frequency in which the HLA-B*58:01 screening test was ordered since 2012 to the estimated frequency of new prescriptions for allopurinol prescribed for the management of gout among the East Asians. Results We report 5 cases of East Asian patients exposed to allopurinol for management of gout between 2012 and 2016, who developed DRESS (4 patients) or SJS/TEN (1 patient). All were of HLA-B*58:01 genotype, representing preventable cases. The HLA-B*58:01 test was ordered 6 times in 2012, whereas the estimated number of new cases of allopurinol-prescribed gout among patients of East Asian descent during that time period was 13. For 2012, testing was ordered for only 46% of at-risk patients. Conclusion We continue to observe cases of severe cutaneous drug reactions among high-risk individuals due to allopurinol exposure. The HLA-B*58:01 screening test for allopurinol hypersensitivity is underutilized in our geographic area.
Pharmaceutical Care Practice in Community and Institutional Drug Retail Outlets of Gondar Town, North West Ethiopia
Authors: Ayalew Mohammed B , Solomon Lidiya , Abay Solomon 
Published: August 2019

Background Pharmaceutical care (PC) practice in Ethiopia is not well developed and is at its infant stage. As a result, very little is known about the level of involvement of pharmacy professionals in PC activities. Objective The aim of this study was to assess PC practice at drug retail outlets (DROs) of Gondar town and to identify factors associated with it. Method A cross-sectional study was conducted on 150 pharmacy professionals working in 55 DROs located in Gondar town, Northwest Ethiopia. Data on sociodemographic characteristics of respondents, their involvement in PC activities, handling of drug-related problems (DRPs), and consultation with colleagues and other health-care providers were collected and analyzed using statistical package for social sciences (SPSS) version 21. Results Majority of study participants were degree holders in pharmacy (68.7%) and work in community DROs (78%). Over half of the respondents (56.5%) were found to practice good PC, asking at least 3 of their last 5 patients what the goal of their drug therapy was. Nearly a quarter (24%) of pharmacy professionals did not document the desired therapeutic objectives for all the 5 patients they served. Handling of DRPs is poor for majority (76%) of the pharmacy professionals. Respondents working in the community DROs and diploma holders are poorly involved in PC activities. Age < 30 years, male sex, and working in the community DROs are significantly associated with poorer relation with colleague and other health-care providers. Conclusions Pharmacy professionals working in DROs of Gondar town have little involvement in the provision of PC. Especially, their handling of DRPs is very poor. The level of involvement of pharmacy professionals on some types of PC services was significantly associated with their sex, age, working site, and level of education.