bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and wake comparison of horizontal and vertical axis wind turbines under varying surface roughness conditions
Authors: Mendoza Victor , Chaudhari Ashvinkumar , Goude Anders 
Published: December 2018

AbstractA numerical study of both a horizontal axis wind turbine (HAWT) and a vertical axis wind turbine (VAWT) with similar size and power rating is presented. These large scale turbines have been tested when operating stand‐alone at their optimal tip speed ratio (TSR) within a neutrally stratified atmospheric boundary layer (ABL). The impact of three different surface roughness lengths on the turbine performance is studied for the both turbines. The turbines performance, the response to the variation in the surface roughness of terrain, and the most relevant phenomena involved on the resulting wake were investigated. The main goal was to evaluate the differences and similarities of these two different types of turbine when they operate under the same atmospheric flow conditions. An actuator line model (ALM) was used together with the large eddy simulation (LES) approach for predicting wake effects, and it was implemented using the open‐source computational fluid dynamics (CFD) library OpenFOAM to solve the governing equations and to compute the resulting flow fields. This model was first validated using wind tunnel measurements of power coefficients and wake of interacting HAWTs, and then employed to study the wake structure of both full scale turbines. A preliminary study test comparing the forces on a VAWT blades against measurements was also investigated. These obtained results showed a better performance and shorter wake (faster recovery) for an HAWT compared with a VAWT for the same atmospheric conditions.
Modification of isoprene synthesis to enable production of curcurbitadienol synthesis inSaccharomyces cerevisiae
Authors: Qiao Jing , Luo Zuliang , Cui Shengrong , Zhao Huan , Tang Qi , Mo Changming , Ma Xiaojun , Ding Zimian 
Published: December 2018

AbstractCucurbitane-type triterpenoids such as mogrosides and cucurbitacins that are present in the plants of Cucurbitaceae are widely used in Asian traditional medicine. Cucurbitadienol is the skeleton of cucurbitane-type triterpenoids. As an alternative production strategy, we developed baker’s yeast Saccharomyces cerevisiae as a microbial host for the eventual transformation of cucurbitadienol. The synthetic pathway of cucurbitadienol was constructed in Saccharomyces cerevisiae by introducing the cucurbitadienol synthase gene from different plants, resulting in 7.80 mg cucurbitadienol from 1 L of fermentation broth. Improving supplies of isoprenoid precursors was then investigated for increasing cucurbitadienol production. Cucurbitadienol production increased to 21.47 mg/L through the overexpression of a global regulatory factor (UPC2) gene of triterpenoid synthase. In addition, knockout of the ERG7 gene increased cucurbitadienol production from 21.47 to 61.80 mg/L. Finally, fed-batch fermentation was performed, and 63.00 mg/L cucurbitadienol was produced. This work is an important step towards the total biosynthesis of valuable cucurbitane-type triterpenoids and demonstrates the potential for developing a sustainable and secure yeast biomanufacturing platform for triterpenoids.
Interdisciplinary Mitigation of Opioid Misuse in Musculoskeletal Patients
Authors: Saigal Ammar N. , Jones Henderson M. 
Published: December 2018

Background The opioid prescribing patterns of orthopedic surgeons have been shown to play a role in exacerbating rates of opioid misuse among post-surgical patients. Demonstrable success has been appreciated by combining policy-level approaches and clinical education–based strategies to inform patients of alternative modalities of post-operative analgesia. Questions/Purposes The purpose of this review was to address two questions: What are the most substantiated measures orthopedic surgeons can take to limit opioid misuse or addiction among their patients? What advantages are gained in orthopedic surgeons’ collaborating with other healthcare professionals with influence over patients’ post-operative opioid exposure? Methods We searched two databases for articles on multidisciplinary policy–based solutions to mitigating the opioid overdose crisis among musculoskeletal patients. Articles produced from the search were searched for further evidence supporting the use of standardized clinical and administrative protocols in mitigating opioid misuse within this patient population. Successful approaches to mitigating misuse of opioids in this demographic were synthesized from recurring themes in the studies. Results Multiple articles support orthopedic surgeons being aware of the risk factors for chronic opioid use among their patients, as well as multidisciplinary strategies involving orthopedic surgeons and other healthcare/governmental professionals to address the burden of the opioid crisis on surgical patients. Conclusions Addressing the misuse of opioids among orthopedic patients requires appropriate prescribing practices and long-term support of patients. Collaboration between surgeons and policymaking entities is recognized as an effective population-wide approach to preventing opioid dependence, misuse, and addiction.
Intended, Unintended, and Unknown Consequences of Contact
Authors: Bagci Sabahat C. , Turnuklu Abbas 
Published: December 2018

Abstract. We investigated the role of positive and negative contact on outgroup attitudes, collective action tendencies, and psychological well-being among minority (Kurds) and majority (Turks) group members in a conflict area ( N = 527), testing ingroup identification, relative deprivation, and perceived discrimination as potential mediators in these associations. Contrary to recent research studies demonstrating the superiority of negative contact effects, positive contact was generally a stronger determinant of the dependent variables, directly and indirectly, in both groups, although negative contact also had some direct and indirect associations with the outcomes. Findings highlight the need to incorporate the role of positive and negative contact to provide a full understanding of the potential benefits/costs of the contact strategy in conflict settings.
No Evidence That Experiencing Physical Warmth Promotes Interpersonal	Warmth
Authors: Chabris Christopher F. , Heck Patrick R. , Mandart Jaclyn , Benjamin Daniel J. , Simons Daniel J. 
Published: December 2018

Abstract. Williams and Bargh (2008) reported that holding a hot cup of coffee caused participants to judge a person’s personality as warmer and that holding a therapeutic heat pad caused participants to choose rewards for other people rather than for themselves. These experiments featured large effects ( r = .28 and .31), small sample sizes (41 and 53 participants), and barely statistically significant results. We attempted to replicate both experiments in field settings with more than triple the sample sizes (128 and 177) and double-blind procedures, but found near-zero effects ( r = −.03 and .02). In both cases, Bayesian analyses suggest there is substantially more evidence for the null hypothesis of no effect than for the original physical warmth priming hypothesis.
The Sexual Double Standard in the Real World
Authors: Marks Michael J. , Young Tara M. , Zaikman Yuliana 
Published: December 2018

Abstract. The sexual double standard (SDS) has traditionally been studied by examining evaluations of hypothetical targets. Although much knowledge has been gained regarding the SDS by using this methodology, the literature thus far has suffered from a lack of ecological validity. The goal of the present study was to determine whether the SDS emerged in evaluations of participants’ real-life friends and acquaintances. Participants ( n = 4,455) evaluated a single, randomly assigned male or female friend or acquaintance whose sexual history they were familiar with. Women were evaluated more negatively as their number of sexual partners increased, whereas number of partners was not related to evaluations of men. The SDS was not moderated by the closeness of the relationship between the participant and the target person.
Earthquake/Tsunami‐Linked Imprints in the Equatorial F Region Zonal Plasma Drifts and Spatial Structures of Plasma Bubbles
Authors: Gurram P. , Kakad B. , Ravi Kumar M. , Bhattacharyya A. 
Published: December 2018

AbstractWe report preseismic and postseismic distinct features observed in equatorial ionospheric F region in Indian longitude during two major earthquakes that occurred on 28 March 2005 (Mw=8.6) and 26 December 2004 (Mw=9.1) with epicenters near Sumatra, Indonesia. We used spaced receiver scintillation observations on a 251‐MHz signal transmitted from a geostationary satellite and recorded at dip equatorial station Tirunelveli, which is ≈2,200 km away from the epicenter of these earthquakes. On 28 March 2005, we noticed significant enhancement (≈88.5 m/s) in F region zonal plasma drift as compared to their seasonal quiet time drifts, 20 min prior to the start of earthquake. This implies the presence of additional vertically downward electric field of approximately 3 mV/m, which is linked with the earthquake mechanism. It is unusual because so far we have not encountered such feature on either magnetically quiet or disturbed days. Spatial scales associated with equatorial spread F irregularities generated in the postsunset hours on this earthquake day are considerably smaller. It suggests that the earthquake‐linked electric field influenced the structuring and evolution of equatorial spread F irregularities on this earthquake day. Another earthquake that occurred on 26 December 2004 triggered a tsunami. We noticed that the earthquake‐ and tsunami‐linked effects in the F region plasma drifts are distinctly observed even 18.5 hr after the earthquake.
Meter‐Scale Experiments on Magma‐Water Interaction
Authors: Sonder Ingo , Harp Andrew G. , Graettinger Alison H. , Moitra Pranabendu , Valentine Greg A. , Büttner Ralf , Zimanowski Bernd 
Published: December 2018

AbstractInteraction of magma with groundwater or surface water can lead to explosive phreatomagmatic eruptions. Questions of this process center on effects of system geometry and length and time scales, and these necessitate experiments at larger scale than previously conducted in order to investigate the thermohydraulic escalation behavior of rapid heat transfer. Previous experimental work either realized melt‐water interaction at similar meter scales, using a thermite‐based magma analog in a confining vessel, or on smaller scale using ≃0.4 kg remelted volcanic rock in an open crucible, with controlled premix and a ≃5 J kinetic energy trigger event. The new setup uses 55 kg melt for interaction, and the timing and location of the magma‐water premix can be controlled on a scale up to 1 m. A trigger mechanism is a falling hammer that drives a plunger into the melt (≃28 J kinetic energy). Results show intense interaction (
) at relatively low magma/water mass ratio. A video analysis quantifies rate and amount of melt ejection and compares results with those using the same melt in the smaller scale setup. Experiments show that on the meter scale intense interaction can start spontaneously without an external trigger if the melt column above the initial mixing location is larger than 0.3 m. Experiments suggest that buoyant rise of water domains in a melt column could promote explosive interaction. We assess interaction scenarios between introduced water domains and a magma column, some of which could result in eruptions of Strombolian style, promoting brecciation and incorporation of wall rock debris into a magma column.
Surface Temperatures and Water Ice Sublimation Rate of Oxo Crater: A Comparison With Juling Crater
Authors: Formisano M. , Federico C. , Magni G. , Raponi A. , De Sanctis M.C. , Frigeri A. 
Published: December 2018

AbstractDwarf planet Ceres is characterized by several sites hosting (or have hosted) ice‐rich patches as revealed by the Dawn's Visible and InfraRed spectrometer. The study of the illumination conditions including the effects of the local topography become critical in the estimation of the ice lifetime as well as the water vapor production rate. In this work we applied a 3‐D thermophysical model in order to study the illumination conditions on the shape model, derived on the basis of the images acquired by the Dawn's Framing Camera during the Survey mission phase, and to calculate the surface temperatures and water sublimation rates. We are interested in a crater in the northern hemisphere (42°), Oxo, which hosts water ice in its southern wall. A comparison with the surface temperatures and water sublimation rates of another Ceres' crater, Juling, is carried out. Water ice sublimation rate of its ice‐rich patch suggests that the Oxo crater probably is not the source of the emission detected by Herschel, a source that could be represented instead by the Juling crater.
Sex specific effects of pre-pubertal stress on hippocampal neurogenesis and behaviour
Authors: Brydges Nichola Marie , Moon Anna , Rule Lowenna , Watkin Holly , Thomas Kerrie L. , Hall Jeremy 
Published: December 2018

AbstractExperience of traumatic events in childhood is linked to an elevated risk of developing psychiatric disorders in adulthood. The neurobiological mechanisms underlying this phenomenon are not fully understood. The limbic system, particularly the hippocampus, is significantly impacted by childhood trauma. In particular, it has been hypothesised that childhood stress may impact adult hippocampal neurogenesis (AHN) and related behaviours, conferring increased risk for later mental illness. Stress in utero can lead to impaired hippocampal synaptic plasticity, and stress in the first 2–3 weeks of life reduces AHN in animal models. Less is known about the effects of stress in the post-weaning, pre-pubertal phase, a developmental time-point more akin to human childhood. Therefore, we investigated persistent effects of pre-pubertal stress (PPS) on functional and molecular aspects of the hippocampus. AHN was altered following PPS in male rats only. Specifically males showed reduced production of new neurons following PPS, but increased survival in the ventral dentate gyrus. In adult males, but not females, pattern separation and trace fear conditioning, behaviours that rely heavily on AHN, were also impaired after PPS. PPS also increased the expression of parvalbumin-positive GABAergic interneurons in the ventral dentate gyrus and increased glutamic acid decarboxylase 67 expression in the ventral hilus, in males only. Our results demonstrate the lasting effects of PPS on the hippocampus in a sex- and time-dependent manner, provide a potential mechanistic link between PPS and later behavioural impairments, and highlight sex differences in vulnerability to neuropsychiatric conditions after early-life stress.
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas
Authors: Rosario S. R. , Long M. D. , Affronti H. C. , Rowsam A. M. , Eng K. H. , Smiraglia D. J. 
Published: December 2018

AbstractUnderstanding metabolic dysregulation in different disease settings is vital for the safe and effective incorporation of metabolism-targeted therapeutics in the clinic. Here, using transcriptomic data for 10,704 tumor and normal samples from The Cancer Genome Atlas, across 26 disease sites, we present a novel bioinformatics pipeline that distinguishes tumor from normal tissues, based on differential gene expression for 114 metabolic pathways. We confirm pathway dysregulation in separate patient populations, demonstrating the robustness of our approach. Bootstrapping simulations were then applied to assess the biological significance of these alterations. We provide distinct examples of the types of analysis that can be accomplished with this tool to understand cancer specific metabolic dysregulation, highlighting novel pathways of interest, and patterns of metabolic flux, in both common and rare disease sites. Further, we show that Master Metabolic Transcriptional Regulators explain why metabolic differences exist, can segregate patient populations, and predict responders to different metabolism-targeted therapeutics.
Neuroinspired unsupervised learning and pruning with subquantum CBRAM arrays
Authors: Shi Yuhan , Nguyen Leon , Oh Sangheon , Liu Xin , Koushan Foroozan , Jameson John R. , Kuzum Duygu 
Published: December 2018

AbstractResistive RAM crossbar arrays offer an attractive solution to minimize off-chip data transfer and parallelize on-chip computations for neural networks. Here, we report a hardware/software co-design approach based on low energy subquantum conductive bridging RAM (CBRAM®) devices and a network pruning technique to reduce network level energy consumption. First, we demonstrate low energy subquantum CBRAM devices exhibiting gradual switching characteristics important for implementing weight updates in hardware during unsupervised learning. Then we develop a network pruning algorithm that can be employed during training, different from previous network pruning approaches applied for inference only. Using a 512 kbit subquantum CBRAM array, we experimentally demonstrate high recognition accuracy on the MNIST dataset for digital implementation of unsupervised learning. Our hardware/software co-design approach can pave the way towards resistive memory based neuro-inspired systems that can autonomously learn and process information in power-limited settings.
Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures
Authors: Thanzeel F. Yushra , Balaraman Kaluvu , Wolf Christian 
Published: December 2018

AbstractClick reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chemistry, metal coordination or supramolecular assemblies, quantitative analysis of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without by-product formation or complicate equilibria often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and water. The ruggedness and practicality of this approach are demonstrated by comprehensive analysis of nonracemic monoamine samples and crude asymmetric imine hydrogenation mixtures without work-up. Click chemosensing addresses increasingly important time efficiency, cost, labor and chemical sustainability aspects and streamlines asymmetric reaction development at the mg scale.
Identifying quasi-2D and 1D electrides in yttrium and scandium chlorides via geometrical identification
Authors: Wan Biao , Lu Yangfan , Xiao Zewen , Muraba Yoshinori , Kim Junghwan , Huang Dajian , Wu Lailei , Gou Huiyang , Zhang Jingwu , Gao Faming , Mao Ho-kwang , Hosono Hideo 
Published: December 2018

AbstractDeveloping and understanding electron-rich electrides offers a promising opportunity for a variety of electronic and catalytic applications. Using a geometrical identification strategy, here we identify a new class of electride material, yttrium/scandium chlorides Y(Sc)xCly (y:x < 2). Anionic electrons are found in the metal octahedral framework topology. The diverse electronic dimensionality of these electrides is quantified explicitly by quasi-two-dimensional (2D) electrides for [YCl]+∙e− and [ScCl]+∙e− and one-dimensional (1D) electrides for [Y2Cl3]+∙e−, [Sc7Cl10]+∙e−, and [Sc5Cl8]2+∙2e− with divalent metal elements (Sc2+: 3d1 and Y2+: 4d1). The localized anionic electrons were confined within the inner-layer spaces, rather than inter-layer spaces that are observed in A2B-type 2D electrides, e.g. Ca2N. Moreover, when hydrogen atoms are introduced into the host structures to form YClH and Y2Cl3H, the generated phases transform to conventional ionic compounds but exhibited a surprising reduction of work function, arising from the increased Fermi level energy, contrary to the conventional electrides reported so far. Y2Cl3 was experimentally confirmed to be a semiconductor with a band gap of 1.14 eV. These results may help to promote the rational design and discovery of new electride materials for further technological applications.
Identification of the salusin-β receptor using proteoliposomes embedded with endogenous membrane proteins
Authors: Shichiri Masayoshi , Nonaka Daisuke , Lee Lyang-Ja , Tanaka Kenji 
Published: December 2018

AbstractAlthough orphan G protein-coupled receptors (GPCRs) have been used as targets to discover unidentified natural ligands, increasing numbers of non-GPCRs have been found to mediate important biological functions. Bioinformatics of genome and cDNA resources predict putative bioactive peptides, demanding an alternative approach to efficiently unravel cell surface targets. In silico analysis of a full-length cDNA library previously allowed us to identify salusin-β, a parasympathomimetic/pro-atherosclerotic peptide with unique physicochemical properties. Here, we show that the β-chain of ATP synthase is a cell surface receptor for salusin-β by utilizing artificial liposomes embedded with endogenous membrane proteins directly transferred from animal tissues while retaining the ligand-binding capability. Conventional techniques using detergents identified a β-actin-profilin complex as membrane-associated salusin-β-binding proteins, but failed to identify the cell surface receptor. Since the α-chain of ATP synthase is a principal cell surface target for angiostatin, a potent endogenous angiogenesis inhibitor, we investigated whether salusin-β modulates angiogenesis. Salusin-β inhibited cell surface ATP synthase activity and prevented sarcoma cell-induced angiogenesis in an in vivo mouse air sac model. Therefore, salusin-β binds to membrane-bound ATP synthase and acts as an angiogenesis inhibitor. The current methodology allows the identification of novel cell surface targets, irrespective of the receptor structure.
The novel EHEC gene asa overlaps the TEGT transporter gene in antisense and is regulated by NaCl and growth phase
Authors: Vanderhaeghen Sonja , Zehentner Barbara , Scherer Siegfried , Neuhaus Klaus , Ardern Zachary 
Published: December 2018

AbstractOnly a few overlapping gene pairs are known in the best-analyzed bacterial model organism Escherichia coli. Automatic annotation programs usually annotate only one out of six reading frames at a locus, allowing only small overlaps between protein-coding sequences. However, both RNAseq and RIBOseq show signals corresponding to non-trivially overlapping reading frames in antisense to annotated genes, which may constitute protein-coding genes. The transcription and translation of the novel 264 nt gene asa, which overlaps in antisense to a putative TEGT (Testis-Enhanced Gene Transfer) transporter gene is detected in pathogenic E. coli, but not in two apathogenic E. coli strains. The gene in E. coli O157:H7 (EHEC) was further analyzed. An overexpression phenotype was identified in two stress conditions, i.e. excess in salt or arginine. For this, EHEC overexpressing asa was grown competitively against EHEC with a translationally arrested asa mutant gene. RT-qPCR revealed conditional expression dependent on growth phase, sodium chloride, and arginine. Two potential promoters were computationally identified and experimentally verified by reporter gene expression and determination of the transcription start site. The protein Asa was verified by Western blot. Close homologues of asa have not been found in protein databases, but bioinformatic analyses showed that it may be membrane associated, having a largely disordered structure.