bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kollagenosen und Psychoneuroimmunologie – Beispiel systemischer Lupus erythematodes
Authors: Schubert Christian 
Published: October 2019

ZusammenfassungDie Kollagenosen einschließlich des systemischen Lupus erythematodes (SLE) sind chronische Autoimmunkrankheiten, für deren Pathogenese die derzeitige Biomedizin keine Erklärung und damit auch keine kausale Therapie bereithält. Die Psychoneuroimmunologie (PNI) als empirische Realisierung des biopsychosozialen Modells ermöglicht durch die Hereinnahme nichtstofflicher, insbesondere psychischer und psychosozialer Entitäten in die wissenschaftliche Auseinandersetzung mit diesen chronischen, teils lebensbedrohlichen Entzündungserkrankungen einen neuen Zugang zu Diagnostik und Therapie. Dies wird in der vorliegenden Arbeit mithilfe von Ergebnissen aus integrativen Einzelfallstudien, einem speziell zur Erfassung psychoneuroimmunologischer Komplexität entwickelten Forschungsdesign, an Patientinnen mit SLE dargelegt.
Prädiktoren der Inanspruchnahme von kardiovaskulären und respiratorischen Notfallaufnahmen – welchen Einfluss hat die Umwelt?
Authors: Krefis Anne Caroline , Fischereit Jana , Hoffmann Peter , Sorbe Christina , Pinnschmidt Hans , Augustin Matthias , Augustin Jobst 
Published: October 2019

Zusammenfassung
Ziel der Studie In den letzten Jahren ist eine zunehmende Anzahl von Notfallaufnahmen zu beobachten. Unklar ist, ob neben einer Leistungsverlagerung vom ambulanten in den stationären Sektor auch andere Ursachen, wie sich verändernde Umweltfaktoren, relevant sind. Ziel der Arbeit war, Zusammenhänge der Anzahl kardiovaskulärer und respiratorischer Notfallaufnahmen mit Umweltvariablen zu untersuchen.
Methodik Hochkorrelierte Umweltdaten wurden in eine Faktorenanalyse einbezogen. Durch Kreuzkorrelationsfunktionen wurden die Umweltvariablen mit Zeitverzögerungen, die die höchste Korrelation mit der Anzahl der Notfallaufnahmen zeigten, in Modellanalysen u. a. zusammen mit Wochentag und Interaktionen berücksichtigt.
Ergebnisse Das finale Regressionsmodell erklärte 47% der Variation der respiratorischen Notfallaufnahmen, die Haupteffekte mit den höchsten Notfallaufnahmen am Montag zeigten (B=10,69; p<0,001). Für die Jahreszeit zeigten sich signifikante Einflüsse mit höchsten Notfallaufnahmen im Herbst. Die Daten zeigten keine direkten Zusammenhänge zwischen Umweltvariablen und Anzahl der respiratorischen Notfallaufnahmen. Ergebnisse der kardiovaskulären Analysen waren weniger aussagekräftig (R2=0,20). Ein signifikanter Zusammenhang zwischen Wochentag und Anzahl kardiovaskulärer Notfallaufnahmen wurde identifiziert (p<0,001).
Schlussfolgerung Die Ergebnisse deuten darauf hin, dass der Wochentag den größten Einfluss auf kardiovaskuläre und respiratorische Notfallaufnahmen in Hamburg hat. Künftig sollen Umweltdaten auf Mikroebene erhoben und für weitere Analysen genutzt werden, um eine höhere Modellgüte und bessere Interpretierbarkeit zu erreichen.
Renale Denervation: Die Zeit ist noch nicht reif für den kommerziellen Einsatz
Authors: Menne Jan 
Published: October 2019

ZusammenfassungEine blutdrucksenkende Wirkung der renalen Denervation ist bisher nur in Studien mit kurzer Nachbeobachtungsdauer (6 Monate) gesichert. Der placebokorrigierte Blutdruckeffekt ist gering und beträgt systolisch 4 – 8 mmHg. Den gleichen Effekt erreicht man mit einer antihypertensiven medikamentösen Therapie, die nur einen Bruchteil kostet und wofür ein kardiovaskulärer Vorteil belegt ist. Auch ist derzeit unklar, wie lange der Effekt einer renalen Denervation anhält. Im Tiermodell ist eine rasche Re-Innervation dokumentiert. Daher kann zum jetzigen Zeitpunkt der Einsatz einer renalen Denervation nicht empfohlen werden. Mehrere Fragen müssen in randomisierten, geblindeten Studien zuvor beantwortet sein: 1) Wie umfangreich muss die Ablation sein und wie sind die Langzeitergebnisse nach 3 – 5 Jahren? 2) Führen unterschiedliche Ablationstechniken zu unterschiedlichen Kurz- und Langzeitergebnissen? 3) Gibt es Patientenkollektive, die besonders profitieren? 4) Werden die kardiovaskuläre Morbidität und Letalität gesenkt? Bis diese Ergebnisse vorliegen, bleibt die medikamentöse Therapie mit Fixkombinationen das Mittel der Wahl.
Reduced Expression of Chl1 gene
Impairs Insulin Secretion by Down-Regulating the
Expression of Key Molecules of β-cell
Function
Authors: Taneera Jalal , Dhaiban Sarah , Hachim Mahmood , Mohammed Abdul Khader , Mukhopadhyay Debasmita , Bajbouj Khuloud , Hamoudi Rifat , Salehi Albert , Hamad Mawieh 
Published: October 2019

AbstractSilencing of Chl1 gene expression has been
previously reported to reduce insulin secretion.
Nevertheless, the mechanism underlying this effect
remains unclear. In this study, we performed a
serial of studies to investigate how Chl1
affects insulin secretion in INS-1 cells.
RNA-sequencing was used to investigate the
expression of CHL1 in human adipose, liver,
muscle, and human islets. Silencing of Chl1
in INS-1 cells was done to assess its impact on
the insulin secretion, content, cell viability,
and apoptosis. In addition, gene set enrichment
analysis (GSEA) was performed to identify possible
molecular signatures that associate with
Chl1 expression silencing.RNA sequencing data revealed a high expression of
CHL1 in pancreatic islets and adipose
tissues compared to liver and muscles tissues.
Diabetic islets exhibited a lower expression of
CHL1 as compared to non-diabetic islets.
CHL1 expression was found to correlate
positively with insulin secretory index,
GLP1R but inversely with HbA1c
and BMI. Silencing of Chl1 in INS-1 cells
markedly reduced insulin content and secretion.
The expression of key molecules of β-cell function
including Insulin, Pdx1, Gck, Glut2,
and Insrβ was down-regulated in
Chl1-silenced cells at transcriptional and
translational levels. Cell viability, apoptosis,
and proliferation rate were not affected. GSEA
showed that the insulin-signaling pathway was
influenced in Chl1-silenced cells.
Silencing of Chl1 impairs β-cell function by
disrupting the activity of key signaling pathways
of importance for insulin biosynthesis and
secretion.
Targeting Nanotechnologies for the Treatment of Thrombosis and Cardiovascular Disease
Authors: Palazzolo Jason Sam , Westein Erik , Hagemeyer Christoph Eugen , Wang Ting-Yi 
Published: October 2019

AbstractThrombosis is characterized by the formation of in vivo blood clots that are localized within arterial or venous blood vessels. These thrombi form beyond the need for physiologically healthy hemostatic responses and can lead to significant medical issues for affected individuals. Unfortunately, the existing standard-of-care therapies for treating thrombosis are systemic in their therapeutic design; therefore, they interfere with the patient's physiological hemostasis. Examples of the severe clinical side effects commonly associated with currently available therapies include, but are not limited to, bleeding complications. Therefore, there is a profound demand for novel therapeutic interventions that can circumvent these debilitating complications, while offering improved therapeutic efficacy. Recent advancements in nanotechnology present an opportunity to develop novel and improved drug delivery systems to meet this clinical demand. Preclinical investigations have begun to uncover the potential of nanotechnology, particularly in the treatment of thrombosis and also in nonhemostatic cardiovascular diseases. This article reviews recent preclinical studies aimed at developing a diverse array of different nanotechnologies for treating thrombosis as well as heart diseases. This review will also outline the limitations with current nanotechnologies and what challenges need to be overcome to translate these novel therapies to the clinic.
Effect of etch-and-rinse and self-etching adhesive systems on hardness uniformity of resin cements after glass fiber post cementation
Authors: da Cruz Fernanda Zander Grande , Grande Christiana Zander , Roderjan Douglas Augusto , Arrais César Augusto Galvão , Samra Adriana Postiglione Bührer , Calixto Abraham Lincoln 
Published: October 2019

ABSTRACTObjectives: To evaluate the effects of etch-and-rinse and self-etching adhesive systems on Vickers hardness (VHN) uniformity of dual-cured resin cements after fiber post cementation.Methods: Fifty glass fiber posts were cemented into bovine roots using the following cementing systems: Prime&Bond 2.1 Dual Cure and Enforce with light-activation (PBDC-LCEN); Prime&Bond 2.1 and Enforce with light-activation (PB-CLEN); Prime&Bond 2.1 Dual Cure and Enforce without light exposure (PBDC-SCEN); ED Primer and Panavia 21 (ED-SCPN); and Clearfil SE Bond and Panavia 21 (CF-SCPN). The roots were stored in distilled water for 72 h and transversely sectioned into thirds (coronal, medium, and apical). The VHN values of the resin cement layers were measured close to the post and to the dentin wall on the transversely sectioned flat surfaces. The results were analyzed by three-way repeated measures analysis of variance (ANOVA) and Tukey’s post-hoc test (pre-set alpha of 5%).Results: Most resin cements presented higher VHN values near the post than near the dentin
wall. The ED-SCPN group showed the highest VHN values regardless of the root third, while the selfcured
group PBDC-SCEN exhibited the lowest values. The resin cements from the light-activated
groups PBDC-LCEN and PB-LCEN showed lower VHN values at the apical third than at the coronal
third. The VHN values were not influenced by the root third in self-cured groups PBDC-SCEN, EDSCPN,
and ED-SCPN.Conclusions: Depending on the product, bonding agents might promote changes in hardness uniformity of resin cements after post cementation. (Eur J Dent 2012;6:248-254)
Comparative analysis of rural poverty and inequality in the UK and the US
Authors: McAreavey Ruth , Brown David L. 
Published: October 2019

AbstractScholars on both sides of the Atlantic have grappled with the difficulties of conducting comparative research on rural issues in general, and on rural poverty and inequality in particular. Shortall and Warner have observed that “The UK-US dialog is highly illustrative of how seemingly similar situations turn out to be full of complexity and difference.” That complexity and difference can serve to turn researchers away from comparative collaborations. We begin our paper with an overview of some of the general differences (and similarities) between how rural scholars in the UK and US have examined poverty and inequality in rural areas. Analysis of the two welfare regimes in these countries provides the backdrop for examining specific aspects of deprivation for rural people and communities. Our paper draws on our experience as members of a trans-Atlantic research group to illustrate the type of organisational infrastructure that can support international, interdisciplinary collaboration. We conclude by offering suggestions for future comparative research. Our paper progresses earlier debates in rural studies on the challenges of doing comparative US-UK analysis.
Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities
Authors: Tahir Salahaldin A. , Gao Jianjun , Miura Yuji , Blando Jorge , Tidwell Rebecca S. S. , Zhao Hao , Subudhi Sumit K. , Tawbi Hussein , Keung Emily , Wargo Jennifer , Allison James P. , Sharma Padmanee 
Published: October 2019

Significance
A substantial portion of cancer patients treated by immune checkpoint (IC) therapy develop immune-related adverse events (irAEs), which result in significant morbidity and mortality. We sought to understand the mechanisms of these irAEs and to identify biomarkers to predict irAEs to maximize the clinical benefits of IC therapy. We screened plasma samples from patients who developed IC therapy-induced hypophysitis or pneumonitis against a cDNA expression library of the brain or lungs and directly identified autoimmune antibodies correlating with hypophysitis or pneumonitis. Our data suggest that these autoantibodies correlate with hypophysitis or pneumonitis and should be tested as the first predictive biomarkers for early detection, timely treatment, and close monitoring of these 2 potentially fatal irAEs.
A Survey Paper on Smart Parking System
Authors: Baron Sam B. , Lokesh Reddy A. , Prabhakar A. 
Published: October 2019

Abstract
Start your abstract here… As there is a development in surge hour gridlock especially in the midst of the apex hours of the day, it is difficult to stop the vehicle in the halting opening. To handle this issue we are proposing sagacious halting system. So we are proposing a Shrewd ceasing system which enables the customer to find the nearest halting domain and gives openness of halting spaces in that individual ceasing zone. It prevalently revolve around diminishing the time in finding the halting openings and moreover it keeps up a vital separation from the unnecessary voyaging. Along these lines it decreases the fuel use. This system uses Cloud Computing and Internet of things
Smart Irrigation and Tank Monitoring System
Authors: Kunal Kumar , Azhar Hussain Md. , Srinivasan N , Albert Mayan J. 
Published: October 2019

AbstractWater, which is regarded to be one of the mostimportant part for the growth of plants in agriculture should be utilized properly. The paper is focused on the smart irrigation of farms as well as monitoring the tank automatically so as to make better irrigation system and tank monitoring which will be beneficial in conserving water and irrigating fields in a smart way. For this project purpose we are integrating different sensors like DHT11, Soil Moisture sensor Ultra sonic sensor, etc. These sensors communicate with the micro controller. Micro-controller perform its action as per its instructions. The proposed framework may prompt upgrade the cultivating rehearses, overcoming the water crises and developingan upgraded agricultural system for the country.
Li-Fi BASED REAL TIME VIDEO TRANSMISSON FOR PATIENT MONITORING SYSTEM
Authors: Hashwanth Saikumar K. , Akshay Teja K. , Ravi T. , Karthikeyan S. 
Published: October 2019

Abstract
The aim of this work is to achieve live surveillance of the patient using LI-FI (light fidelity). Lifi is an advanced and promising technology can be used in many medical applications. In this paper, a prototype of live video broadcast using LEDs is proposed. The prototype presented transfers the data with single LED, and is capable of illumination as well as data broadcast. Whole process is kick started by converting analog signal into digital form in transmitter section. LM359 IC amplifies video signal with two inverting amplifiers which possess high gain bandwidth and allows high frequencies and it is coupled to LED which accelerates the transmission process and it’s geared at high speed by receiving the high frequency video signal in digital form by a photo detector. The output from the receiver circuit is analog output given to television module using a RCA cable.
An Advanced Attendance Marking system using facial Recognition
Authors: Vamsikrishna Jarugula , Anudeep Kollipara , Jegan Antony Marcilin L. , Balamurugan V. 
Published: October 2019

Abstract
With advancement in computing and telecommunications technologies, digital images and videos are playing main role in the current information era. Human face is an important bio-metric object in image and video database of surveillance systems. Detecting and location of human faces and facial features in an image sequence is an important task in dynamic environments, such as videos where noise conditions, illuminations, locations of subjects and pose can vary significantly from frame to frame. An automated attendance system is used for marking human face recognition in real time for college to mark the attendance for their staff and students. Smart automated attendance marking using real time face recognition is a real world solution which comes with day to day activities of handling employees. Here multiple user faces are detected and recognized with the data base trained multiple texture based notability.
Incremental Frequent Mining Human Activity Patterns for Health Care Applications
Authors: Vignesh Krishna Sai G. , Sai Kumar Pavan , Viji Amutha Mary A. 
Published: October 2019

Abstract
Nowadays, there is a consistently expanding relocation of individuals to urban territories. Human services administrations is a Standout amongst the most difficult perspectives that is extraordinarily influenced by the immense deluge of individuals to downtown areas. In such change a great many homes are being with brilliant gadgets which create huge volume s of indexical information that can be dissected to help savvy city administrations. In this paper, we propose a model that uses savvy home huge information as a methods for learning and finding human movement designs for wellbeing applicati ons.for this we utilize visit design mining, bunch investigation and forecast to gauge and dissect vitality utilization changes the tenants behaviour. Since, individuals propensities are generally disti nguished by ordinary schedules, demonstrates in dividuals’ troubles in taking tend to themselves, for example, not planning nourishment or not utilizing shower/bath.our places of business the need to break down transient vitality utilization at mach ine level, which is straightforwardly identified with human exercises. This exploration utilizes the UK Domestic Appliance Level Electricity dataset(UK-Dale) time arrangement information of energy utilization gathered from 2012-2015 with time determ ination of six seconds for five houses with 109 app aratus from SouthernEngland.The information from shrewd meters are mined in the quantum/information cut of 24hrs, and the outcomes are kept up cro-sswise over progressive mining exercises.the after effect of distinguishing human movement desig-ns from machine use are displayed in points of interest.
Performance Analysis of Belief Propagation Polar Code Decoder
Authors: Karthick C , Vino T , Babji T , Naveen P 
Published: October 2019

Abstract
Attributable to their ability accomplishing execution and low encoding and interpreting intricacy, polar codes have gotten noteworthy consideration as of late. Successive cancellation decoding (SCD) and belief propagation decoding (BPD) are two mainstream approaches for disentangling polar codes. SCD, in spite of having less computational intricacy when contrasted and BPD, experiences long inertness because of the serial idea of the SC calculation. BPD, then again, is parallel in nature and is more alluring for low-dormancy applications. Nonetheless, because of the iterative idea of BPD, the required inertness and vitality dispersal increment straightly with the quantity of emphasis. In this paper, we propose a novel plan in light of sub-factor diagram solidifying to lessen the normal number addition the normal number of cycles required by BPD, which specifically converts into bring down inactivity and vitality dissemination. Besides, the equipment design for the proposed plot is created and contrasted and the best in class BPD executions for (1024,512) polar codes.
IOT Based Omni Directional Robot Control by Using ARM-Series
Authors: Hitesh K.N. , Kumar Reddy Juturu Manoj , Ilayarajaa KT , Joany RM , Vijayakumar V 
Published: October 2019

Abstract
On this research, controlling the omni directional mobile robot is divided by two controls, high level control which covers positioning and path tracking, also the low-level control which covers omnidirectional kinematic, speed control, heading lock and communication. This also covers thread management, priority fixation and stack memory fixation. Program is divided into several main threads, i.e., IMU, speed controller, communication and motion thread (kinematic). Stack memory configuration for the above threads can be allotted as IMU thread with 1024 bytes of stack memory, speed control with 512 bytes, motion management with 512 bytes, communication with 128 bytes. IMU execution time lapses for 5.6uS, speed control elapses for 19.7uS, whereas motion elapses for 11uS and communication elapses for 1.2mS. Robot’s low-level control which includes robot movement kinematic (e.g., heading lock, speed control etc) is required to support the predefined system and enhance the robot sensor’s response in navigation.
A Octa- Rectangular Slot Array based Patch Antenna for Multiband Applications
Authors: Karthikeyan V. , Raveendra Muddineni , Hemasri Challa , Praneetha Reddy Male , Harshitha B. 
Published: October 2019

Abstract
In this paper, a octa rectangular-slot array based patch antenna for multiband applications has been proposed. The operating frequency range of proposed antenna is 11-21.817 GHz in the X, Ku and K bands. This antenna designed with octa rectangular shaped slots on rectangular patch antenna. The FR4 (Flame Retardant)substrate material is used in this antenna, which has relative permittivity 3.66, relative permeability 1, loss tangent 0.0018 and thickness of 2mm.The design has been stimulated by using HFSS software. The performance of the antenna is analysed with the help of characteristics of return loss, VSWR, bandwidth, gain and directivity at each band. It gives resonance frequencies at 11.1GHz, 14.3GHz, 16.1GHz, 17.5GHz, 19.3 GHz and 20.3GHz.
Interaction between damage and time-dependent deformation of mortar in concrete: 3D FE study at meso-scale
Authors: Gambarelli S , Ožbolt J 
Published: October 2019

Abstract
Creep of concrete can be partly attributed to the time-dependent deformation of cement paste and partly to the interaction between load-induced damage of mortar (hardened cement paste) and its non-elastic deformations [1]. The heterogeneity of concrete and related interaction between load-induced damage and non-elastic deformation of mortar can have significant influence on the long-term response of concrete. Some aspects of the problem have been investigated in [1] through 3D finite element (FE) analysis of a concrete cylinder at meso-scale. The concrete is treated as a bi-phase composite material, consisting of coarse aggregate and mortar matrix. The constitutive law for mortar is based on the microplane theory, while the aggregate is assumed to be linear elastic. The results obtained for basic creep and shrinkage, at different levels of applied uniaxial compressive load (both separate and combined action) are reported in [1]. This paper mainly focuses on the effect of cyclic variation of environmental temperature and its interaction with the load-induced damage, basic creep and shrinkage of mortar. It is shown that with higher loading level the increase of time deformation of concrete becomes progressive and the variation of environmental temperature strongly influences time-dependent concrete response.