bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological data analysis and diagnostics of compressible magnetohydrodynamic turbulence
Authors: Makarenko I. , Bushby P. , Fletcher A. , Henderson R. , Makarenko N. , Shukurov A. 
Published: August 2018

The predictions of mean-field electrodynamics can now be probed using direct numerical simulations of random flows and magnetic fields. When modelling astrophysical magnetohydrodynamics, it is important to verify that such simulations are in agreement with observations. One of the main challenges in this area is to identify robust quantitative measures to compare structures found in simulations with those inferred from astrophysical observations. A similar challenge is to compare quantitatively results from different simulations. Topological data analysis offers a range of techniques, including the Betti numbers and persistence diagrams, that can be used to facilitate such a comparison. After describing these tools, we first apply them to synthetic random fields and demonstrate that, when the data are standardized in a straightforward manner, some topological measures are insensitive to either large-scale trends or the resolution of the data. Focusing upon one particular astrophysical example, we apply topological data analysis to H iobservations of the turbulent interstellar medium (ISM) in the Milky Way and to recent magnetohydrodynamic simulations of the random, strongly compressible ISM. We stress that these topological techniques are generic and could be applied to any complex, multi-dimensional random field.
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
Authors: Palermo Giulia , Chen Janice S. , Ricci Clarisse G. , Rivalta Ivan , Jinek Martin , Batista Victor S. , Doudna Jennifer A. , McCammon J. Andrew 
Published: August 2018

Abstract
Ongoing measles outbreak in Greece related to the recent European-wide epidemic
Authors: Georgakopoulou T. , Horefti E. , Vernardaki A. , Pogka V. , Gkolfinopoulou K. , Triantafyllou E. , Tsiodras S. , Theodoridou M. , Mentis A. , Panagiotopoulos T. 
Published: August 2018

AbstractWe report an ongoing measles outbreak in Greece. The first cases were notified through the mandatory notification system on May 2017 in Northern Greece and concerned a cluster of three imported cases in unvaccinated Roma siblings. So far, 3150 cases have been reported in all 13 Regions. Initially, the outbreak mainly affected Greek Roma but as it progressed it spread to non-minority Greek nationals. The outbreak reached its ultimate peak on week 10/2018 but from week 15/2018 has been gradually declining. Most cases (60.6%) were Roma (especially children <10 year-old) followed by non-minority Greek nationals (29.3%; mostly young adults). The majority (80.4%) were unvaccinated. Interestingly, 129 (4.1%) cases were healthcare workers (HCWs). Genotype B3 was identified by molecular methods in all 87 cases tested. Overall, 61.3% of the cases were hospitalised. Complications were reported in 17.1% of the cases among which four deaths. The outbreak occurred after 3 years without local endemic measles transmission. Extensive vaccination implemented as the major public health measure managed to prevent the emergence of a large number of cases in refugee/migrant hosting sites. Mitigation efforts currently focus on raising awareness among HCWs and closing the immunisation gap in populations with suboptimal vaccination coverage.
Like and share: associations between social media engagement and dietary choices in children
Authors: Baldwin Heather J , Freeman Becky , Kelly Bridget 
Published: August 2018

AbstractObjectiveTo examine whether social media and online behaviours are associated with unhealthy food and beverage consumption in children.DesignA cross-sectional online survey was used to assess Internet and social media use, including engagement with food and beverage brand content, and frequency of consumption of unhealthy foods and beverages. Linear regression models were used to examine associations between online behaviours, including engagement with food and beverage brand content, and consumption of unhealthy foods and beverages, adjusting for age, sex and socio-economic status.SettingNew South Wales, Australia, in 2014.SubjectsChildren aged 10–16 years (n417).ResultsWatching food brand video content on YouTube, purchasing food online and seeing favourite food brands advertised online were significantly associated with higher frequency of consumption of unhealthy foods and drinks after adjustment for age, sex and socio-economic status.ConclusionsChildren who have higher online engagement with food brands and content, particularly through online video, are more likely to consume unhealthy foods and drinks. Our findings highlight the need to include social media in regulations and policies designed to limit children’s exposure to unhealthy food marketing. Social media companies have a greater role to play in protecting children from advertising.
22q13 deletion syndrome: communication disorder or autism? Evidence from a specific clinical and neurophysiological phenotype
Authors: Ponson Laura , Gomot Marie , Blanc Romuald , Barthelemy Catherine , Roux Sylvie , Munnich Arnold , Romana Serge , Aguillon-Hernandez Nadia , Malan Valérie , Bonnet-Brilhault Frédérique 
Published: August 2018

AbstractPhelan–McDermid syndrome is related to terminal 22q13 deletions of various sizes affecting the SHANK3 gene. In this neurodevelopmental disorder, behavioural symptoms of autism spectrum disorder (ASD) are reported in half of cases. Extensive clinical and neurophysiological characterization is lacking to understand the genotype–phenotype correlation. Eighteen patients (8 males, mean age 12.7 years, SD = 9.2) with known 22q13 deletions were fully explored with determination of deletion size, along with behavioural, language and cognitive standardized assessments. Neurophysiological indices previously reported to be altered in autism (i.e., eye tracking in a social/non-social task and auditory evoked potential mismatch) were also recorded. Thirty-nine percent met ASD clinical criteria, exceeding cut-off scores on both ADI-R (Autism Diagnosis Interview based on the period spanning 4–5 years of age) and ADOS-2 (Autism Diagnosis Observation Schedule for the current period). All patients had intellectual disability and language disability. Deletion size was significantly correlated with expressive and receptive language disability but not with ASD standardized assessment scores. Developmental Quotient tended to be lower in patients with the largest deletions. Using Eye Tracking, smaller pupil size, which is typically described in ASD, was not observed in these patients. Furthermore, atypical shortened latency of mismatch negativity response previously reported in ASD was not observed, whereas the N250 pattern, related to language, was affected. Language disability combined with cognitive deficits may lead to autistic behavioural symptoms, but with different neurophysiological networks compared to typical autism. These results highlight the indication for early speech therapy rather than intensive autism programme to treat these patients.
The urinary microbiome associated with bladder cancer
Authors: Bučević Popović Viljemka , Šitum Marijan , Chow Cheryl-Emiliane T. , Chan Luisa S. , Roje Blanka , Terzić Janoš 
Published: August 2018

AbstractRecent findings suggest that human microbiome can influence the development of cancer, but the role of microorganisms in bladder cancer pathogenesis has not been explored yet. The aim of this study was to characterize and compare the urinary microbiome of bladder cancer patients with those of healthy controls. Bacterial communities present in urine specimens collected from 12 male patients diagnosed with bladder cancer, and from 11 healthy, age-matched individuals were analysed using 16S sequencing. Our results show that the most abundant phylum in both groups was Firmicutes, followed by Actinobacteria, Bacteroidetes and Proteobacteria. While microbial diversity and overall microbiome composition were not significantly different between groups, we could identify operational taxonomic units (OTUs) that were more abundant in either group. Among those that were significantly enriched in the bladder cancer group, we identified an OTU belonging to genus Fusobacterium, a possible protumorigenic pathogen. In an independent sample of 42 bladder cancer tissues, 11 had Fusobacterium nucleatum sequences detected by PCR. Three OTUs from genera Veillonella, Streptococcus and Corynebacterium were more abundant in healthy urines. However, due to the limited number of participants additional studies are needed to determine if urinary microbiome is associated with bladder cancer.
A Swath Label-Free Proteomics insight into the Faah−/− Mouse Liver
Authors: Hamid Zeeshan , Summa Maria , Armirotti Andrea 
Published: August 2018

AbstractFatty acid amide hydrolase (FAAH) is an important enzyme for lipid metabolism and an interesting pharmacological target, given its role in anandamide breakdown. The FAAH−/− genotype is the most widely used mouse model to investigate the effects of a complete pharmacological inhibition of this enzyme. In this paper, we explore, by means of label-free SWATH proteomics, the changes in protein expression occurring in the liver of FAAH−/− knockout (KO) mice. We identified several altered biological processes and pathways, like fatty acid synthesis and glycolysis, which explain the observed phenotype of this mouse. We also observed the alteration of other proteins, like carboxylesterases and S-methyltransferases, apparently not immediately related to FAAH, but known to have important biological roles. Our study, reporting more than 3000 quantified proteins, offers an in-depth analysis of the liver proteome of this model.
Japanese beetles’ feeding on milkweed flowers may compromise efforts to restore monarch butterfly habitat
Authors: Baker Adam M. , Potter Daniel A. 
Published: August 2018

AbstractThe eastern North American migratory population of monarch butterflies (Danaus plexippus) is in serious decline. Habitat restoration, including adding millions of host plants to compensate for loss of milkweed in US cropland, is a key part of the international conservation strategy to return this iconic butterfly to sustainable status. We report here that Popillia japonica, a polyphagous, invasive beetle, aggregates and feeds on flowers of Asclepias syriaca, the monarch’s most important larval food plant, reducing fruiting and seed set by >90% and extensively damaging milkweed umbels in the field. The beetle’s ongoing incursion into the monarch’s key breeding grounds in the US Midwest is likely to limit pollination and outcrossing of wild and planted milkweeds, reducing their capacity to colonize new areas via seeds. Popillia japonica represents a previously undocumented threat to milkweeds that should be considered in models for monarch habitat restoration.
Weighing the two stellar components of the Galactic bulge
Authors: Zoccali M. , Valenti E. , Gonzalez O. A. 
Published: August 2018

Context.Recent spectroscopic surveys of the Galactic bulge have unambiguously shown that the bulge contains two main components, which are best separated by their iron content, but also differ in spatial distribution, kinematics, and abundance ratios. The so-called metal poor component peaks at [Fe/H] ∼ −0.4, while the metal rich component peaks at [Fe/H] ∼ +0.3. The total metallicity distribution function is therefore bimodal with a dip at [Fe/H] ∼ 0. The relative fraction of the two components changes significantly across the bulge area.
Aims. We provide, for the first time, the fractional contribution of the metal poor and metal rich stars to the stellar mass budget of the Galactic bulge and its variation across the bulge area.
Methods. This result follows from the combination of the stellar mass profile obtained empirically, by our group, from VISTA Variables in the Vía Láctea data, with the relative fraction of metal poor and metal rich stars, across the bulge area, derived from the GIRAFFE Inner Bulge spectroscopic Survey.
Results. We find that metal poor stars make up 48% of the total stellar mass of the bulge, within the region |l| < 10, |b| < 9.5 and that the remaining 52% are made up of metal rich stars. The latter dominate the mass budget at intermediate latitudes |b| ∼ 4, but become marginal in the outer bulge (|b| > 8). The metal poor component is more axisymmetric than the metal rich component, and it is at least comparable and possibly slightly dominant in the inner few degrees. As a result, the metal poor component, which does not follow the main bar, is not marginal in terms of the total mass budget as previously thought, and this new observational evidence must be included in bulge models. While the trend of the total radial velocity dispersion follows the total stellar mass, when we examine the velocity dispersion of each component individually, we find that metal poor stars have higher velocity dispersion where they make up a smaller fraction of the stellar mass, and vice versa. This is due to the kinematical and spatial distribution of the two metallicity components being significantly different, as already discussed in the literature.
Indocyanine Green Lymphangiography as an Adjunct for the Optimal Identification and Management of Lymphatic Leaks in the Groin
Authors: Rebecca Alanna , Mahabir Raman , Pflibsen Lacey , Hillberg Nadine , Jensen Claire , Casey William 
Published: August 2018

Background The treatment of lymphatic leaks and lymphoceles in the groin can be challenging with no optimal management determined to date. We postulate that indocyanine green (ICG) lymphangiography improves visualization of the site of a lymphatic leak and can optimize their management.
Methods A retrospective review was conducted of all cases in which ICG lymphangiography was used in the management of lymphatic leaks in the groin over an 18-month span. The inciting surgical procedure resulting in the leak was determined. Following thorough debridement, ICG was injected intradermally in the distal extremity and the site of the lymphatic leak was documented (superficial or deep) and oversewn. Outcomes were reported with regard to healing, infection, time to drain removal, and adjunctive procedures.
Results Fifteen patients underwent ICG lymphangiography during the surgical treatment of a lymphatic leak in the groin during the study period. In all cases, the site of the lymphatic leak was accurately identified and oversewn. In eight cases, the site of the lymphatic leak was in the subcutaneous tissue superficial to the femoral vessels rather than medial to the femoral vessels in the area of the lymph node basin. A local muscle flap was used in 10 cases simultaneously. All wounds healed primarily without an associated wound or infection.
Conclusion ICG lymphangiography facilitated the identification of lymphatic leaks in the groin and optimized their management in these challenging cases, many of which may have been missed if the area around the inguinal lymph node basin was treated exclusively.
Genital Sensibility in the Neophallus: Getting a Sense of the Current Literature and Techniques
Authors: Morrison Shane , Massie Jonathan , Dellon A. 
Published: August 2018

Introduction Phalloplasty attempts to achieve a functional and aesthetic phallus. Sensation is a key component for sexual pleasure. Sensation is also important for protection in the setting of penile implant insertion. Little data are available on genital sensibility outcomes after phalloplasty, and there are no standardized approaches for assessment of either sensibility or erogenous perception.
Methods A literature search of PubMed, Google Scholar, and MEDLINE databases was conducted with terms related to genital sensibility after phalloplasty. Data on patient demographics, nerves used for coaptation, and measurements of genital sensibility were collected. Pooled event rates were determined for recovered glans sensibility and recovered erogenous sensation using a Freeman–Tukey arcsine transformation.
Results A total of 341 articles were identified of which 26 met the inclusion criteria for final analysis. The dorsal cutaneous branch of the pudendal nerve and ilioinguinal were the most common donor nerves. The lateral and medial antebrachial cutaneous and lateral femoral cutaneous were the most common recipient nerves. Pooled event rates suggest that some recovered glans sensibility occurs in more than 70% of cismale patients and in more than 90% of transmale patients. Recovered “erogenous” sensation occurs in more than 75% of cismale patients and more than 95% of transmale patients. In cismale patients, outcomes of recovered glans sensibility and erogenous sensation may be better for upper extremity recipient nerves than lower extremity recipient nerves.
Conclusions Based on the limited data in current literature on genital sensibility after phalloplasty, it is difficult to draw evidence-based conclusions. Yet data support improved outcomes with innervation. A validated outcome measure of “erogenous sensation” and a standardized approach to measuring cutaneous sensibility are required.
Necrotic Lesions Following Elective Urological Surgery in an Infant
Authors: Fernández-Ibieta María 
Published: August 2018

Case Report An 11-month-old female infant presented on the first postoperative (PO) day following an elective pyeloplasty, a dark bluish erythema of her lumbotomy wound, plus a satellite lesion of the same characteristics. Fever and sepsis developed, and despite broad spectrum antibiotics (meropenem and vancomycin) were started, a diagnosis of necrotizing soft-tissue infection (NSTI or necrotizing fasciitis) was established. Surgical debridement of both lesions was performed on day 3 PO, and a surgical contamination (ring retractor blade) was suspected, due to the particular geography of the lesion. Urine and blood cultures yielded no bacteria, but tissue culture grew Pseudomonas aeruginosa. At PO 6th day, lesions still appeared exudative and poorly perfused, so vacuum-assisted therapy (VAT) treatment was started. Exudate control, perfusion, and granulation improved in consecutive days, which permitted direct closure (no graft needed) at PO day 12.
Discussion P. aeruginosa can be a fatal cause of type I NSTI. It has been reported rarely in adult series, with a prevalence of 4%, but it can be a major pathogen in pediatric NSTI. Added to an early recognition, aggressive surgery and debridement are required, in combination with antibiotic therapy, to limit the spread of the infection. In our case, despite surgical debridement being performed on day 3 PO, both wounds maintained scarce perfusion, and debris and exudate were poorly controlled with usual silver foams and daily nursery cures. VAT pediatric device was then added, which rapidly improved surgical bed, enhancing tissue perfusion and granulation in the following days.
New Artin-Schelter regular and Calabi-Yau algebras via normal extensions
Authors: Chirvasitu Alex , Kanda Ryo , Smith S. 
Published: August 2018

We introduce a new method to construct 4-dimensional Artin-Schelter regular algebras as normal extensions of (not necessarily noetherian) 3-dimensional ones. The method produces large classes of new 4-dimensional Artin-Schelter regular algebras. When applied to a 3-Calabi-Yau algebra our method produces a flat family of central extensions of it that are 4-Calabi-Yau, and all 4-Calabi-Yau central extensions having the same generating set as the original 3-Calabi-Yau algebra arise in this way. Each normal extension has the same generators as the original 3-dimensional algebra, and its relations consist of all but one of the relations for the original algebra and an equal number of new relations determined by “the missing one” and a tuple of scalars satisfying some numerical conditions. We determine the Nakayama automorphisms of the 4-dimensional algebras obtained by our method and as a consequence show that their homological determinant is 1. This supports the conjecture in [J. Algebra 446 (2016), pp. 373–399] that the homological determinant of the Nakayama automorphism is 1 for all Artin-Schelter regular connected graded algebras. Reyes-Rogalski-Zhang proved this is true in the noetherian case [Trans. Amer. Math. Soc. 369 (2017), pp. 309–340, Cor. 5.4].
Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex—Mouse Subplate Zone
Authors: Singh Mandakini B , White Jesse A , McKimm Eric J , Milosevic Milena M , Antic Srdjan D 
Published: August 2018

Abstract
Subplate (SP) neurons exhibit spontaneous plateau depolarizations mediated by connexin hemichannels. Postnatal (P1–P6) mice show identical voltage pattern and drug-sensitivity as observed in slices from human fetal cortex; indicating that the mouse is a useful model for studying the cellular physiology of the developing neocortex. In mouse SP neurons, spontaneous plateau depolarizations were insensitive to blockers of: synaptic transmission (glutamatergic, GABAergic, or glycinergic), pannexins (probenecid), or calcium channels (mibefradil, verapamil, diltiazem); while highly sensitive to blockers of gap junctions (octanol), hemichannels (La3+, lindane, Gd3+), or glial metabolism (DLFC). Application of La3+ (100 μM) does not exert its effect on electrical activity by blocking calcium channels. Intracellular application of Gd3+ determined that Gd3+-sensitive pores (putative connexin hemichannels) reside on the membrane of SP neurons. Immunostaining of cortical sections (P1–P6) detected connexins 26, and 45 in neurons, but not connexins 32 and 36. Vimentin-positive glial cells were detected in the SP zone suggesting a potential physiological interaction between SP neurons and radial glia. SP spontaneous activity was reduced by blocking glial metabolism with DFLC or by blocking purinergic receptors by PPADS. Connexin hemichannels and ATP release from vimentin-positive glial cells may underlie spontaneous plateau depolarizations in the developing mammalian cortex.
Superunitary Representations of Heisenberg Supergroups
Authors: de Goursac Axel , Michel Jean-Philippe 
Published: August 2018

Abstract
Numerous Lie supergroups do not admit superunitary representations (SURs) except the trivial one, for example, Heisenberg and orthosymplectic supergroups in mixed signature. To avoid this situation, we introduce in this paper a broader definition of SUR, relying on a new definition of Hilbert superspace. The latter is inspired by the notion of Krein space and was developed initially for noncommutative supergeometry. For Heisenberg supergroups, this new approach yields a smooth generalization, whatever the signature, of the unitary representation theory of the classical Heisenberg group. First, we obtain Schrödinger-like representations by quantizing generic coadjoint orbits. They satisfy the new definition of irreducible SURs and serve as ground to the main result of this paper: a generalized Stone–von Neumann theorem. Then, we obtain the superunitary dual and build a group Fourier transformation, satisfying Parseval theorem. We eventually show that metaplectic representations, which extend Schrödinger-like representations to metaplectic supergroups, also fit into this definition of SURs.