bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kualitas Keberagamaan Orang Tua Terhadap Motivasi Belajar PAI Siswa
Authors: Isnawati Iis 
Published: July 2019

Upaya untuk meningkatkan motivasi belajar siswa dalam Pendidikan Agama Islam, pihak madrasah beserta para guru sudah melakukan upaya untuk meningkatkan motivasi belajar siswa, terutama dalam meningkatkan motivasi belajar Agama Islam. Guru telah melakukan upaya dari mulai memotivasi siswa secara verbal yaitu melalui bimbingan dan nasihat, serta melalui bentuk nilai tertulis. Selain itu, pihak sekolah juga mengadakan fasilitas berupa boarding school untuk memotivasi siswa. Akan tetapi, hal tersebut tidak memperlihatkan hasil yang cukup baik. Bertolak dari pernyataan di atas, maka muncul suatu persoalan bagaimana pengaruh kualitas keberagamaan orang terhadap motivasi belajar Pendidikan Agama Islam pada siswa. Adapun tujuan dari penelitian ini adalah untuk mengetahui: 1)Kualitas keberagamaan orang tua, 2)Motivasi belajar siswa, dan 3)Pengaruh kualitas keberagamaan orang tua terhadap motivasi belajar Pendidikan Agama Islam pada siswa kelas X Madrasah Aliyah Negeri 1 Majalengka. Penelitian ini bertolak dari suatu pemikiran bahwa buah jatuh tidak jauh dari pohonnya, maksudnya secara asumsi ketika kualitas keberagamaan orang tua baik maka keberagamaan termasuk motivasi belajar PAI anakpun baik, begitupun sebaliknya. Dari asumsi tersebut dapat di tarik hipotesis bahwa semakin tinggi kualitas keberagamaan orang tua, maka semakin tinggi pula motivasi belajar PAI siswa. Dan semakin rendah kualitas keberagamaan orang tua, maka semakin rendah pula motivasi belajar PAI siswa. Untuk membuktikan hipotesis tersebut diadakan penelitian dengan menggunakan metode deskriptif korelasional, sedangkan teknik pengumpulan datanya dengan observasi, wawancara, dan angket. Alat analisis yang digunakan adalah pendekatan analisis parsial yang menghasilkan variabel X berdistribusi normal, indikator pengetahuan variabel X berdisribusi tidak normal dan variabel Y berdistribusi normal, maka korelasi ini menggunakan rumus korelasi product moment dan korelasi rank. Hasil penelitian diperoleh kesimpulan: 1) Realitas variabel X rata-rata sebesar 3,45 yang ditafsirkan kepada kategori cukup dengan data berdistribusi normal, terbukti karena harga x² hitung 2,74 < x² tabel 9,488. 2) Realitas variabel Y rata-rata sebesar 2,69 yang ditafsirkan kepada kategori cukup dengan data berdistribusi normal, yang terbukti karena harga x² hitung 4,19 < x² tabel 9,488. 3) Pengaruh antara variabel X dengan variabel Y diperoleh Rxy = 0,38 yaitu kategori korelasi rendah. Dan taraf signifikasi diperoleh thitung sebesar 2,47 dan ttabel sebesar 2,024 dengan taraf signifikasi 5%, sehingga thitung > ttabel, yakni terdapat pengaruh yang signifikan antara variabel X dan variabel Y. Oleh karena itu hipotesis yang diajukan dinyatakan: Ha diterima dan Ho ditolak. Kemudian besarnya pengaruh diperoleh 8% hal ini menunjukkan masih ada 92% faktor lain yang mempengaruhi motivasi belajar PAI siswa.
PENANAMAN NILAI-NILAI KEARIFAN LOKAL DALAM MENINGKATKAN PERILAKU KEBERAGAMAAN PESERTA DIDIK
Authors: Affandy Sulpi 
Published: July 2019

Lokal genius, indigenious knowledge atau local wisdom dapat digali secara ilmiah dari produk kultural dengan interpretasi yang mendalam. Sebagai produk kultural, tradisi budaya mengandung berbagai hal yang menyangkut hidup dan kehidupan komunitas pemiliknya, misalnya sistem nilai, kepercayaan dan agama. Kaidah-kaidah sosial dan etos kerja, bahkan cara bagaimana dinamika sosial itu berlangsung, dengan kata lain, tradisi budaya sebagai warisan leluhur mengandung kearifan lokal (local wisdom) yang dapat dimanfaatkan dalam pemberdayaan masyarakat untuk membentuk kedamaian dan meningkatkan kesejahteraan. Dalam kaitannya dengan kearifan lokal, setiap bangsa atau suku bangsa memiliki sumber yang berbeda dalam pembentukan karakter (character building) generasi penerus bangsanya.Kearifan lokal budaya Sunda yang kaya dengan nilai-nilai positif perlu ditransformasi pada generasi muda melalui pendidikan secara kontinyu dan terus mengalami proses reflektif agar kearifan lokal budaya sunda bisa mendorong karakter sunda yang unggul sehingga pada akhirnya setiap siswa memiliki kecakapan hidup (life skill) yang dibutuhkan dalam kehidupan mereka pada jamannya.Keberagamaan atau religiusitas merupakan tingkat pengetahuan, keyakinan, pelaksanaan dan penghayatan seseorang atas ajaran agama yang diyakininya, atau suatu sikap penyerahan diri kepada suatu kekuatan yang ada di luar dirinya yang diwujudkan dalam aktivitas dan perilaku individu sehari-hari. Dalam pendapat lain Keberagamaan (religiusity) adalah perilaku yang bersumber langsung atau tidak langsung kepada nas. Di pihak lain, keberagamaan menunjuk pada rangkaian perbuatan, perilaku dan kegiatan orang beriman yang telah melaksanakan ajaran tersebut, di dalam kehidupan konkret mereka.Perilaku keberagamaan merupakan respon dari realitas mutlak sesuai dengan konsep Joachim Wach atau imam Abu al-Hasan al-Asy’ary. Untuk mewujudkan satuan perilaku beragama diperlukan suatu proses panjang ynag menyangkut dimensi kemanusiaan baik pada aspek kejiwaan, perorangan maupun kehidupan kelompok. Unsur ini disimpulkan dari sifat ajaran agama yang menjangkau keseluruhan hidup manusia, karena manusia memiliki dimensi kejiwaan perorangan atua kelompok.Untuk meningkatkan keberagamaan peserta didik perlu didukung dengan kaitan wawasan, sikap keberagamaan peserta didik dan juga pembiasaan program yang menanamkan nilai-nilai keberagamaan tersebut. Sehingga nantinya diketahui apakah wawasan peserta didik yang luas akan ilmu agama memastikannya untuk bersikap dan berprilaku yang menunjukkan keberagamaan yang baik.
POLYMORPHISMS OF EXTRACELLULAR CONNECTIVE TISSUE REMODELING PROTEINASES AND <i>MMP2, MMP3, MMP9</i> GENES, AND NEOANGIGENESIS <i>VEGF</i> GENE IN RETINAL MICROANGIOPATHY IN THE PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Shevchenko A. V. , Prokofiev V. F. , Konenkov V. I. , Klimontov V. V. , Tyan N. V. , Chernykh D. V. , Trunov A. N. , Chernykh V. V. 
Published: July 2019

The aim of our study was to perform an association analysis betweenMMP2,MMP3,MMP9,VEGFgene polymorphisms and development of non-proliferative diabetic retinopathy (DR) in the type 2 diabetic patients (DM).201 DM patients: 90 cases of DR and 111 subjects without DR features were included into the study. Polymorphic variants ofMMP2(rs2438650),MMP3(rs3025058),MMP9(rs3918242), andVEGF(rs699947andrs3025039) genes were assayed. The genetic typing was carried out by restriction fragment length polymorphism and TaqMan methods.The analysis of complex genotypes at the five polymorphic positions has revealed some significant findings in positive and negatively incorporated complexes. Increased frequencies ofMMP2-1306 CCgenotype in the group of patients with “early” development of complication, and more frequent combination of high-level HbA1c withMMP2-1306CCandMMP9-1562CTgenotypes were shown in DR patients. Computerassisted modelling with visual reconstruction of network interactions between the genotypes involved into the destruction events and angiogenesis, as well as altered HbA1с levels (an integral parameter of glycemia), has revealed some differences in structural and functional organization of gene-gene and gene- protein interactions between the groups of patients with DRversusthose without this disorder. Сonclusion. A design of interactome biological networks based on transcription regulation and metabolic pathways, as well as their topological analysis allows to build and study interactions of genes and proteins, with reference to pathogenetic studies of DM2 complications aiming for development of approaches to personalized prevention and therapy in future times.
CD20<sup>+</sup>B LYMPHOCYTES, A HIGHLY INFORMATIVE BIOMARKER FOR EARLY DIAGNOSIS OF CHRONIC ENDOMETRITIS
Authors: Ellinidi V. N. , Khromov-Borisov N. N. , Feoktistov A. A. , Lyamina A. V. , Kalinina N. M. 
Published: July 2019

Plasma cells are often considered to be among important criteria in histological diagnosis of chronic endometritis (CE). Low plasma cell numbers in endometrial stroma, uneven distribution and similarity to the cells of cytogenic endometrial stroma represent difficulties with their identification by routine histological methods of study, and their absence prevents distinct diagnosis of CE. The paper presents data on comparative ROC-analysis of two immunohistochemical parameters of chronic endometritis: CD20+B lymphocytes and CD138+ plasma cells (PC). The study group included 937 women with CE, who were examined for infertility and failed IVF attempts. The control group consisted of 103 women without signs of CE who were studied for male infertility factor.The sensitivity of CD20+B cell assays for the diagnosis of CE was 98% (Se = 0.98), thus being 1.44 times higher compared to the sensitivity of CD138+PC, that was, respectively, 68% (Se = 0.68). The specificity of both indicators for the diagnosis of the absence of CE was high, i.e., 98% (Sp = 0.98), and 99% (Sp = 0.99), respectively. The threshold quantitative values for the two endometrial parameters (cutoff point) for the CE diagnosis were also determined when using CD138+PC-1 cell/5mm2 and CD20+B lymphocytes-5cell/5mm2. Analysis of linear regression showed a highly significant (p = 0.00053) relationship of CD138+ PC from CD20+B lymphocytes: With increased numbers of CD20+B lymphocytes, there is a trend for higher CD138+PC numbers which confirms their direct pathogenetic relationship. The topographic and quantitative features of CD20 B lymphocytes in the endometrium determined during immunohistochemical examination allow us to recommend this approach as a highly sensitive and significant early diagnostic indicator of chronic endometritis.
CD39<sup>+</sup> EXPRESSION BY REGULATORY T CELLS IN PULMONARY SARCOIDOSIS AND LOFGREN’S SYNDROME
Authors: Kudryavtsev I. V. , Lazareva N. M. , Baranova O. P. , Golovkin A. S. , Isakov D. V. , Serebriakova M. K. , Ses’ T. P. , Ilkovich M. M. , Totolian Areg A. 
Published: July 2019

Sarcoidosis is a disorder of unknown etiology characterized by development of necrosis-free epithelioid cell granulomas in various tissues. There are two main phenotypes of pulmonary sarcoidosis (PS): Lofgren’s syndrome (LS) is an acute form with favorable outcome, while non-Lofgren’s syndrome (nLS) is a chronic type of disease that can lead to pulmonary fibrosis in 20% of cases.Our study was aimed at investigating changes in the main cell-surface differentiation antigens on peripheral blood regulatory T cells (Tregs) from the patients with first diagnosed PS without treatment (LS, n = 11) and nLS (n = 46) compared to healthy volunteers (HC, n = 26).These indexes might be used as immunological markers for predicting severity of this disorder. Flow cytometry analysis of peripheral blood cell samples demonstrated that the nLS patients had decreased relative numbers of CD3+ cells vs healthy controls, as well as diminished CD3+CD4+ cells vs HC and LS patients. Furthermore, the relative and absolute Treg numbers were also decreased in nLS group vs HC (2.83% (2.47; 3.36) vs 3.33% (2.79; 3.84), p = 0.021), and 37 (29; 52) cells vs 50 (42; 65), p = 0.004, respectively) per one microliter of peripheral blood. Relative number of CD39-positive Тregs in chronic vs acute sarcoidosis patients was associated with 51.02% (38.20; 61.62) vs 48.64% (41.46; 63.72) that was significantly (p < 0.001 and p = 0.007, respectively) higher than in HC (39.52% (11.55; 46.34). We have found that “naïve” (CD45R0-CD62L+) Тregs did not significantly differ in percentage of CD39- and CD73-positive cells in all the groups tested. Moreover, CD45R0+CD62L+ Тregs in LS and nLS patients contained significantly more CD39-positive cells (69.66% (61.92; 79.34) and 67.62% (61.92; 79.34), respectively, compared to 47.55% (15.74; 65.32) in HC (p < 0.001 and p = 0.004, respectively). In case of CD45R0 + CD62LTregs able to exit from the circulation and migrate to the site of inflammation, an increased percentage of CD39-positive subset was noted only in patients with chronic sarcoidosis and HC (61.79% (55.12; 73.09) and 57.27% (16.03; 66.98), p = 0.006). Enhanced CD39 expression on Tregs seems to be related to chronic immune response, so that antigen elimination becomes impossible due to Treg overactivation, as shown in patients with sarcoidosis and some other chronic autoimmune and infectious disorders.
IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
Authors: Vitkina T. I. , Novgorodtseva T. P. , Kalinina E. P. , Lobanova E. G. , Antonyuk M. V. 
Published: July 2019

Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.
A NEW METHOD BASED ON THE USE OF IMMOBILIZED SINGLE-DOMAIN ANTIBODIES TO REMOVE CERTAIN MAJOR PROTEINS FROM BLOOD PLASMA HELPS TO REDUCE NONSPECIFIC SIGNAL IN AN IMMUNOASSAY
Authors: Goryainova O. S. , Khan E. O. , Ivanova T. I. , Tillib S. V. 
Published: July 2019

A generally underestimated problem of immunoassays is its susceptibility to various interferences, being the Achilles heel of these assays (interventions in the analysis). The presence of interfering substances in the patient’s specimen can cause erroneous test sample result, which may lead to incorrect diagnosis and catastrophic consequences for the patient. Hence, one should pay particular attention to identifying possible interferences in the test systems used and, when possible, develop and apply methods to overcome them. The issue of avoiding interference is particularly important for immunoassays of biomarkers in human plasma or serum. In order to reduce possible interferences, it would be desirable to have an opportunity of specific and adaptable pretreatment of blood samples for a specifically assayed marker protein, as applied to a specific test system. We assume that such pretreatment may be done by combining the immunosorbents based on the use of special single-domain antibodies (nanobodies).The nanobodies are recombinant proteins, derivatives of single-domain antigen-recognizing variable fragments of specific antibodies, consisting of a dimer of truncated heavy chains in the complete absence of light chains. Such specific antibodies are detectable in the normal samples taken from members of the Camelidae family (Camelids), and in some species of cartilaginous fishes, along with the common antibodies. The special properties of nanobodies can provide certain advantages in their use, compared with antibodies of traditional structure and their derivatives.In this paper, we have shown for the first time, that the immunosorbents based on certain combination of single-domain antibodies used as ligands able for specifically binding and removal of specific high-abundance human blood proteins, may be selected for a given marker blood antigen in such a way that they will be an effective tool for blood pretreatment, aiming to reduce possible effects of interference and increased sensitivity in the diagnostic “sandwich” enzyme immunoassay. A new method of plasma pretreatment is demonstrated with human plasma samples (at a dilution of 1:40) of two patients. A previously developed model system for detection of lactoferrin protein was used to analyze plasma samples. It is shown that a significantly increased ratio of total detected signal to the nonspecific background signal could be obtained after drastic reduction of this background by affinity removal of 3 major protein fractions, i.e., fibrinogen, IgG alpha-2-macroglobulin from blood plasma samples, using appropriate immobilized single domain antibodies.
Niños y niñas en relación: amistades, enemistades y grupos en clave de género
Authors: Muñoz- Tinoco V. , García Bacete F.J , Jiménez Lagares I , Marande G 
Published: July 2019

Para este trabajo se han analizado las relaciones y grupos de interacción de 774 niños y niñas de 1º de Educación Primaria, una edad apenas contemplada en los estudios de redes sociales, prestando atención a las diferencias relacionadas con el sexo. Maccoby (1998) hacía referencia a niños y niñas como “dos mundos separados”. El estudio de las redes sociales infantiles en las últimas décadas muestra evidencias diversas de que la estructura relacional difiere sustancialmente con el género. Niños y niñas interactúan entre sí con poca frecuencia como amigos o miembros de un mismo grupo. Así, las díadas de amistad más frecuentes son del mismo sexo, igual que ocurre con los grupos de juego. Por otra parte, las niñas suelen interactuar en grupos de menor tamaño y los niños en grupos más numerosos. (Rose y Rudolph, 2006). Los resultados que se presentan en esta comunicación confirman estas diferencias en las afiliaciones de niños y niñas desde temprana edad, resaltándose la relevancia de seguir explorando las características propias de las afiliaciones entre niñas, entre niños y, aunque menos prevalentes, las afiliaciones mixtas. ¿Y qué ocurre con las relaciones conflictivas? El análisis de las díadas de enemistad muestra un patrón distinto para las díadas de aversión mutua, siendo las enemistades mixtas más frecuentes que las amistades entre niños y niñas. Otros estudios encuentran interacciones más negativas entre niños y niñas y sesgos perceptivos negativos hacia compañeros de juego de otro sexo (Rodkin, Pearl, Farmer y Van Acker, 2003; Underwood, Schockner y Hurley, 2001). Estos resultados sugieren que la baja prevalencia de amistades y grupos mixtos no implica necesariamente una ausencia de mirada hacia ese otro mundo del que habla Maccoby, sino interacciones menos satisfactorias. Se concluye que las enemistades pueden constituir un buen escenario para comprender las relaciones intergénero en la infancia, complementando el análisis de las relaciones e interacciones positivas entre niños y niñas.
Meta-percepción social en primer curso de educación primaria. Diferencias de género
Authors: Marande G , García Bacete F.J , Muñoz-Tinoco V. , Jiménez Lagares I. 
Published: July 2019

Ser consciente de las atracciones y rechazos que uno suscita en los compañeros-as de clase es esencial para poder ajustar el propio comportamiento durante las interacciones con los iguales. El objetivo de este estudio es conocer los errores de subestimación y sobreestimación que cometen los niños y niñas al identificar los iguales que los aceptan o los rechazan. Los errores pueden ser de cuatro tipos: subestimación positiva y negativa, sobreestimación positiva y negativa. La subestimación consiste en omitir mencionar que un determinado compañero nos ha nominado, positivamente o negativamente. A la inversa, la sobreestimación consiste en creer que un determinado compañero- a nos ha nominado, positivamente o negativamente, cuando en realidad no lo ha hecho. La muestra estudiada se compone de 809 niños-as (51.3% chicas), que respondieron a un cuestionario de nominaciones sociométricas al inicio de primer curso de educación primaria (Edad media: 6.4 años). Los niños y niñas fueron clasificados sociométricamente en promedios-as, preferidos- as, rechazados-as, controvertidos-as e ignorados-as.Los resultados indican altos porcentajes de errores de metapercepciones sociales, tanto en los chicos como en las chicas. Sin embargo, se observan diferencias de género: las niñas tienen menos subestimación negativa que los niños. Además, las frecuencias de errores cometidos por chicos y chicas varían en función del tipo sociométrico. En general, en los cuatro tipos de errores, los porcentajes de errores cometidos por las chicas son más bajos que en los chicos, independientemente de su tipo sociométrico. A esta corta edad, parece que las chicas perciben más, o saben interpretar mejor, las pistassociales que los chicos. Más concretamente, parece que las chicas son más sensibles a las muestras de rechazo de los compañeros-as, lo que hace que fallan menos que los chicos en omisión de rechazadores.
Prevalence and pattern of anaemia and correlation with booking status in a new Medical College in Haryana, India
Authors: Kashyap Anshika , Bano Tabassum , Babar Nadia 
Published: July 2019

Background: Anaemia is the commonest medical disorder in pregnancy. It is a leading cause of maternal morbidity and mortality. This study analyses the prevalence and pattern of anaemia and correlates it with booking status in a new medical college in rural Haryana.Methods: This retrospective study was conducted to analyze prevalence, severity and morphology of anaemia in hospitalized pregnant patients at the time of labour in a new medical college in rural Haryana. Antenatal booking status was correlated with haemoglobin levels and severity. The study was conducted over a period of six months from Nov ’18 to April’19.Results: 390 singleton labour patients at or near term with no other known medical complications were evaluated. Prevalence of anaemia in the centre serving as a referral with onsite blood bank facilities was as high as 79.7 %. 47.9% of patients did not have even a single antenatal visit. 50.8% had microcytic hypochromic anaemia followed by 32.3% who had normal morphological picture; dimorphic was 14% and macrocytic 2.8%. The prevalence in booked patients was 78.91% compared to 80.1% in unbooked.Conclusions: Anaemia continues to be a major challenge to the obstetric services despite targeted efforts by the government and various organizations to provide free prophylaxis. Iron deficiency or nutritional anaemia is the commonest. However, booking visits, counselling and free distribution of iron tablets doesn’t ensure that the patient is protected from anaemia. This raises concerns about compliance and hence effectiveness of oral iron therapy. An aggressive strategy for diagnosis, prophylaxis and treatment of anaemia as well as a method to ensure compliance must be developed.