bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participatory development of evidence-based patient narrative videos for patients with eating disorders: a methodological approach and pilot data
Authors: Daugelat Melissa-Claire , Gregg Bettina , Adam Sophia Helen , Schag Kathrin , Kimmerle Joachim , Giel Katrin Elisabeth 
Published: November 2024

Abstract
Background
Patient narratives can best be defined as personal stories of persons previously or currently affected by a physical or mental health disorder. The collaborative development and implementation of such narratives reflects a participatory approach between researchers, patients, and members of the public towards the development of new interventions. Patient narratives can foster feelings of support and belonging, as well as increase hope and motivation towards recovery. Aims of this pilot study were (a) the collaborative development of a series of evidence-based patient narrative videos about eating disorders, (b) their initial evaluation with a group of participants without (current) eating disorders, and (c) to provide a reproducible documentation of this methodological approach.

Method
A multi-stage participatory process was used including a) a systematic review, b) focus groups with affected persons, c) the participatory narrative development, and d) an initial pilot study with participants without (current) eating disorders. A former and currently recovered patient was recruited as a lived experience representative, while a psychotherapist provided the same information from a professional perspective. Control group videos featured the lived experience representative discussing a somatic condition unrelated to eating disorders (i.e., torn knee ligament). Two videos were created for each perspective with varying degrees of emotionality of the content.

Results
Nineteen female participants without (current) eating disorders were recruited for the pilot study. All videos received positive ratings, however, participants rated videos in which the lived experience representative discussed her eating disorder as significantly more authentic than the control group videos, as well as significantly more empathic, useful, and better overall than the psychotherapist and control group videos. Participants further indicated a clear preference for videos with higher emotionality, regardless of which perspective or disorder was being presented.

Discussion
The use of patient narratives for eating disorders is a relatively new methodological approach. This paper provides one example of how evidence-based patient narratives can be constructed. The patient narratives created in this study received positive feedback from participants without (current) eating disorders and are currently being tested in a 4-arm randomised controlled pilot study with patients affected by eating disorders.
Regionally extensive ejecta layer of the Australasian tektite strewn field: the MIS 20/19 large meteorite impact in mainland South-East Asia
Authors: Carling Paul A. , Tada Toshihiro , Tada Ryuji , Songtham Wickanet , Cresswell Alan J. , Sanderson David C. W. , Porat Naomi , Duangkrayom Jaroon , Darby Stephen E. , Chansom Praphas 
Published: November 2024

AbstractAspects of the Quaternary sedimentary geology of South-East Asia have proven problematic in terms of interpretation as to the origins and relationships of the surface sediment layers. The MIS 20 large meteorite impact (c., 788 to 785 ka) occurred within mainland South-East Asia, evident from the well-researched ‘Australasian Tektite Strewn Field’ which extends over at least one tenth of the surface of the Earth. Key questions include: 1) whether the sedimentary impact signature is preserved in the Quaternary sediment cover of the region and 2) whether stratigraphic indicators and dating methods can discriminate meteorite impact-related associations of sedimentary strata, despite subsequent reworking and diagenesis. The importance of the questions raised relate to the search for the impact site, which has not been located conclusively. Moreover, the sedimentary signatures of meteorite impacts are not well known and the descriptions in this study should aid the recognition of impact signatures elsewhere in the world. An hypothesis was developed: Surface Quaternary sediments across a wide area of mainland South-East Asia represent the effects of a regionally significant meteorite impact. Over one hundred sedimentary sections were logged across five countries in mainland South-East Asia. Methods used, defining the stratigraphy and sedimentology, include computed tomography and X-ray scanning, geochemistry, magnetic susceptibility, and environmental luminescence as well as conventional grain size analyses. Luminescence analyses were applied to samples from key strata to provide age constraints and indications of reworking through dose distributional analysis of quartz fractions. The results of the investigation explain the nature of the stratigraphy and relate it specifically to the meteorite impact. In this manner, the strata and sedimentary signatures of the ejecta from a large cosmic impact are defined across a broad region, rather than being described at singular and isolated sections. The novelty is the spatial scale of the investigation which nevertheless remains detailed. A summary model of impact stratigraphy is presented that applies to the regional ejecta blanket covering at least 300,000 km2. Tektites were co-deposited with the ejecta and not introduced by surface processes reworking the deposits. Similar models may be applicable outside of mainland South-East Asia, wherever other large impacts are suspected to have occurred.
Epidemiological description of fire blight introduction patterns to Central Asia and the Caucasus region based on CRISPR spacer typing and genome analysis
Authors: Rezzonico Fabio , Bobushova Saykal , Gaganidze Dali , Konurbaeva Mahabat , Mukhanov Sergey , Jordan Sara , Sadunishvili Tinatin , Drenova Nataliya , Smits Theo H. M. , Doolotkeldieva Tinatin 
Published: November 2024

AbstractIn the last two decades, fire blight has progressively spread eastward from Europe and the Mediterranean area to several pome-fruit producing regions of Asia. Its causative agent, the bacterial pathogen Erwinia amylovora, was detected in several new countries, including Georgia, Kyrgyzstan, and Kazakhstan. In the latter two states, the disease creates a threat not only to the commercial apple and pear production, but also to the wild Malus and Pyrus species that constitute the basis of the local forest ecosystems. In this study, we investigated the genetic diversity of the pathogen in Central Asia and the Caucasus region utilizing CRISPR Repeat Regions (CRRs) genotyping and genome sequencing, with the aim to understand its dissemination patterns across the continent. Genome sequence analysis revealed that all strains from these two regions exclusively derived from the archetypal CRR1 genotype A. Our analysis revealed three main E. amylovora clades in Central Asia, with distinct yet partial overlapping geographical distributions. Genomic relationships among isolates indicate that Central Asian strains are genetically closest to those from the Persian region and the Middle East, while the Georgian population is genetically more distant and can align with strains from the Volga District in southern Russia and the Eastern Mediterranean area. Notably, this study also includes strains from the first confirmed occurrences of fire blight in Uzbekistan, Tajikistan, and China. Our findings highlight the importance of phylogenetic analysis and genome sequencing in understanding the phytopathogen epidemics and protecting key agricultural species and the genetic resources of their wild counterparts in the forest.
A comprehensive review of cellulose nanomaterials for adsorption of wastewater pollutants: focus on dye and heavy metal Cr adsorption and oil/water separation
Authors: Yang Yadong , Li Xuanze , Wan Caichao , Zhang Zhe , Cao Wenzhe , Wang Guanyu , Wu Yiqiang 
Published: November 2024

AbstractCellulose is widely distributed in higher plants and constitutes the most abundant natural biopolymer on Earth. Nanocellulose is a cellulose material with nanoscale dimensions, obtained through special processing and treatment. Up to now, nanocellulose has been widely investigated as a biosorbent to absorb various types of pollutants in wastewater due to its excellent properties, such as large specific surface area, antifouling behaviour, high aspect ratio, high heat resistance, excellent mechanical properties, biodegradability and biocompatibility. In addition, nanocellulose can be rationally structured by different recombination techniques such as membranes, sponges, aerogels, hydrogels and microspheres and provide specialised functionality for the adsorption of various types of pollutants from wastewater. This review introduces the basic properties, classification and modification methods of nanocellulose; discusses the preparation strategies of nanocellulose-based recombinant materials (including vacuum/pressurised filtration, sol–gel and electrospinning); reviews research progress in the adsorption of organic dyes and heavy metal Cr, as well as the separation of oil/water using nanocellulose-based recombinant materials; and explores the potential of nanocellulose in treating tannery wastewater. Finally, the problems faced by nanocellulose-based recombinant materials and future prospects are presented.
Graphical Abstract
Liver and spleen stiffness measurement using the new FibroScan module for prediction of esophageal varices and monitoring response to beta blockers in portal hypertension
Authors: Elshimy Ahmed , Abouelhoda Ahmed Mohamed , Al-Banna Wael M. , Farouk Omar 
Published: November 2024

Abstract
Background
This study aimed to assess the clinical use of the new FibroScan module for measurement of liver and spleen stiffness (LS and SS), comparing their usefulness in prediction of esophageal varices (EV) in patients with portal hypertension (PH) and their clinical value for monitoring response to non-selective beta blockers (NSBB) treatment in these cases. The study included 120 patients with compensated cirrhosis and PH, in addition to 30 healthy comparable controls. Based on gastrointestinal endoscopy, patients were classified into three groups: 48 without EV, 42 with small EV, and 30 with large varices needing treatment. Then, abdominal ultrasound and assessment of LS and SS using new FibroScan 630 Expert module were done for both patients and controls. Group 3 patients were then initiated on NSBB (propranolol), and follow-up of these parameters was done after 3 months.

Results
LS and SS were significantly increased in cirrhotic patients compared to controls and were positively correlated with ultrasonography parameters (spleen length and portal vein diameter). Moreover, they were significantly higher in patients with varices than in those without varices (compared to other noninvasive parameters), correlating with varices severity, and significantly decreased with NSBB treatment, especially SS.

Conclusion
Screening of cirrhotic patients for development of EV by elastography (LS and especially SS) using the new FibroScan machine seems to be an optimal method in clinical practice and superior to other noninvasive tests in the diagnosis, assessment of severity, and follow-up of response to treatment in these patients.
Phasor estimation using micro-phasor measurement unit (μPMU) in distribution network for situational awareness
Authors: Deepa B. , Hampannavar Santoshkumar , Mansani Swapna 
Published: November 2024

AbstractPhasor estimation plays a critical role in island detection, fault detection, voltage stability monitoring, and state estimation within power systems. This paper proposes a phasor estimation method using micro-Phasor Measurement Units (µPMUs) in a Smart Distribution Network. A µPMU model is developed utilizing a recursive Discrete Fourier Transform (DFT) algorithm combined with high-precision filters to enhance accuracy. The optimal placement of µPMUs in the distribution network is determined using a Mixed-Integer Linear Programming (MILP) approach for the IEEE 33 bus test system. The model is tested on the IEEE 33 bus system with Electric Vehicle Charging Stations (EVCS) and Distributed Generators (DGs) under both nominal and off-nominal frequencies. The results comply with the IEEE C37.118.1 standard, achieving phasor magnitude errors as low as + 0.01% and frequency accuracy of 1 mHz with minimal ripple. This study demonstrates the robustness and precision of the µPMU model, highlighting its potential for enhancing real-time monitoring and control in smart grid applications.
Horizontal transfer of plasmid-like extrachromosomal circular DNAs across graft junctions in Solanaceae
Authors: Zhang Aijun , Wang Tingjin , Yuan Lu , Shen Yuxin , Liu Ke , Liu Bin , Xu Kexin , Elsadek Mohamed A. , Wang Yiting , Wu Liang , Qi Zhenyu , Yu Jingquan , Zhang Mingfang , Chen Liping 
Published: November 2024

AbstractThe transfer of genetic material between stocks and scions of grafted plants has been extensively studied; however, the nature and frequency of the transferred material remain elusive. Here, we report a grafting system involving woody goji as the stock and herbaceous tomato as the scion, which was developed using in vitro and in vivo approaches; the results confirmed horizontal transfer of multiple nuclear DNA fragments from donor goji cells to recipient tomato cells. Tomato tissues containing goji donor DNA fragments at or near the grafting junctions had a perennial-biased anatomical structure, from which roots or shoots were regenerated. Most of the fragments were plasmid-like extrachromosomal circular DNAs (eccDNAs) present in the regenerants derived from the cells and in their asexual offspring. Plants with transferred eccDNAs in regenerated roots or shoots (designated “Go-tomato”) were grown perennially and showed excellent agronomic performance. The present study provides new insights into the replication, expression, and potential function of eccDNAs in the pleiotropic traits of Go-tomato. Mobile eccDNAs offer evidence of stock-to-scion horizontal DNA transfer beyond chromosomes and organelles, thereby contributing to the molecular understanding of graft-induced genetic variation, evolution, and breeding.
Waiting to Exhale: The Feasibility and Appropriateness of Home Blood Oxygen Monitoring in Oncology Patients Post–Hospital Discharge
Authors: Liu Si-Yang , Doshi Sahil D. , Ebstein AnnMarie Mazzella , Holland Jessie , Sapir Ayelet , Leung Michael , Huang Jennie , Fahy Rosanna , Salvaggio Rori , Begue Aaron , Kuperman Gilad , Polubriaginof Fernanda G.C. , Stetson Peter D. , Mao Jun J. , Panageas Katherine , Li Bob , Daly Bobby 
Published: November 2024

PURPOSE
Pulse oximetry remote patient monitoring (RPM) post–hospital discharge increased during the COVID-19 pandemic as patients and providers sought to limit in-person encounters and provide more care in the home. However, there is limited evidence on the feasibility and appropriateness of pulse oximetry RPM in patients with cancer after hospital discharge.

METHODS AND MATERIALS

This feasibility study enrolled oncology patients discharged after an unexpected admission at the Memorial Sloan Kettering Cancer Center from October 2020 to July 2021. Patients were asked to measure their blood oxygen (O
2
) level daily during the hours of 9
am
-5
pm
during a 10-day monitoring period posthospitalization. An automated system alerted clinicians to blood O
2
levels below 93.0%. We evaluated the feasibility (>50.0% of patients providing at least one measurement from home) and appropriateness (>50.0% of alerts leading to a clinically meaningful patient interaction) of pulse oximetry RPM.

RESULTS

Sixty-two patients were enrolled in the study, with 53.2% female patients and a median age of 68 years. The most prevalent malignancy was thoracic (62.9%). The feasibility metric was met, with 45 patients (72.6%, 45 of 62) providing blood O
2
levels at least once during the 10-day monitoring program. The appropriateness threshold was not met; of the 121 alerts, only 39.7% (48 alerts) was linked to a clinically meaningful interaction.

CONCLUSION

This feasibility study showed that while patients with cancer were willing to measure blood O
2
levels at home, most alerts did not result in meaningful clinical interactions. There is a need for improved patient support systems and logistical infrastructure to support appropriate use of RPM at home.
Development of a Composite Score Based on Carbohydrate Antigen 19-9 Dynamics to Predict Survival in Carbohydrate Antigen 19-9–Producing Patients With Pancreatic Ductal Adenocarcinoma After Neoadjuvant Treatment
Authors: Rompen Ingmar F. , Sereni Elisabetta , Habib Joseph R. , Garnier Jonathan , Galimberti Veronica , Perez Rivera Lucas R. , Vatti Deepa , Lafaro Kelly J. , Hewitt D. Brock , Sacks Greg D. , Burns William R. , Cohen Steven , Kaplan Brian , Burkhart Richard A. , Turrini Olivier , Wolfgang Christopher L. , He Jin , Javed Ammar A. 
Published: November 2024

PURPOSE
Dynamics of carbohydrate antigen 19-9 (CA19-9) often inform treatment decisions during and after neoadjuvant chemotherapy (NAT) of patients with pancreatic ductal adenocarcinoma (PDAC). However, considerable dispute persists regarding the clinical relevance of specific CA19-9 thresholds and dynamics. Therefore, we aimed to define optimal thresholds for CA19-9 values and create a biochemically driven composite score to predict survival in CA19-9-producing patients with PDAC after NAT.

METHODS
Patients with PDAC who underwent NAT and surgical resection from 2012 to 2022 were retrospectively identified from three high-volume centers. CA19-9 nonproducers and patients with 90-day mortality, and macroscopically incomplete resections were excluded. A composite score was created on the basis of relative CA19-9 change and newly defined optimal thresholds of pre- and postneoadjuvant values for overall survival (OS) using patients from two centers and validated using data from the third center.

RESULTS

A total of 492 patients met inclusion criteria in the development cohort. Optimal CA19-9 cutoff values for predicting a difference in OS were 202 U/mL for preneoadjuvant and 78 U/mL for postneoadjuvant levels. Furthermore, increase in CA19-9 during neoadjuvant treatment was associated with worse OS (median-OS, 17.5 months
v
26.0 months;
P
= .008). Not surpassing any or only one of these thresholds (composite score of 0-1) was associated with improved OS compared with patients with 2-3 points (median-OS, 29.9 months
v
15.8 months;
P
< .001). Major serological response (90% decrease of CA19-9) had a positive and negative predictive value of 32% and 88%, respectively.

CONCLUSION
The composite score consisting of CA19-9 levels at diagnosis, after neoadjuvant treatment, and its dynamics demonstrates prognostic discrimination between low and high scores. However, better predictive biomarkers are needed to facilitate treatment decisions during neoadjuvant treatment.
Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission
Authors: Schoeb Manuela , Sintenie Paula J C , Bakker Leontine E H , Biermasz Nienke R , van Haalen Femke M , Nijhoff Michiel F , de Vries Friso , Winter Elizabeth M , Pereira Alberto M , Appelman-Dijkstra Natasha M 
Published: November 2024

Abstract

Objective
Hypercortisolism in endogenous Cushing's syndrome (CS) results in decreased bone mineral density (BMD) and increased fracture risk. Although after remission BMD improves, the fracture rate remains elevated, suggesting that BMD may not adequately reflect fracture risk in this group. The aim was to evaluate bone material properties, another component of bone quality, using impact microindentation in patients with CS in remission.

Methods
Cross-sectional study in 60 CS patients and 60 age-, sex-, and BMD-matched controls at a tertiary referral center between 2019 and 2021. Bone material strength index (BMSi) was measured by impact microindentation using the OsteoProbe® device at the tibia. In addition, laboratory investigation, BMD, and vertebral fracture assessment were performed.

Results
By design, patients and controls were comparable for age (median age 56.5 years), sex (48 women), and BMD at the lumbar spine and femoral neck. They were also comparable regarding the number of fragility fractures (21 vs 27, P = .22). The median time of remission in patients was 6 years (range 1 to 41). Despite comparable BMD, BMSi was significantly lower in CS patients compared to controls (76.2 ± 6.7 vs 80.5 ± 4.9, P &lt; .001). In CS patients, BMSi was negatively correlated with body mass index (r = −0.354, P = .01) but not related to the presence of fracture, physiological hydrocortisone replacement use, other pituitary insufficiencies, or time since remission.

Conclusion
Bone material properties remain altered in patients with endogenous CS, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.
Development of Chronic Thyroiditis During Cyclosporin A Treatment
Authors: Hataya Yuji , Nomura Takumi , Fujishima Yuko , Fujimoto Kanta , Iwakura Toshio , Matsuoka Naoki 
Published: November 2024

Abstract
Cyclosporin A (CsA) is a calcineurin inhibitor used as an immunosuppressant. Although CsA effectively suppresses T cells, excessive suppression of regulatory T cells may exacerbate autoimmune diseases. Here, we report a case of chronic thyroiditis developing during CsA treatment. A 64-year-old woman, on CsA for 2 years for aplastic anemia, presented with a nodule in the right thyroid lobe, raising concern for malignant lymphoma. Right hemithyroidectomy confirmed mucosa-associated lymphoid tissue lymphoma without chronic thyroiditis in the adjacent normal tissue. Owing to the localized lesion, the patient was monitored with a reduced dose of CsA. Initial thyroid ultrasonography showed a normal left lobe; however, hypoechoic areas appeared 1-year postsurgery, followed by diffuse thyroid enlargement and further expansion of these hypoechoic areas. Postoperative fluorodeoxyglucose positron emission tomography showed progressive uptake in the left lobe, and thyroid autoantibodies, initially negative, became positive. Five years later, suspected lymphoma recurrence prompted a residual thyroidectomy, which confirmed mucosa-associated lymphoid tissue lymphoma with chronic thyroiditis. This case suggests that excessive suppression of regulatory T cells by CsA may induce chronic thyroiditis. Further studies on chronic thyroiditis in patients treated with CsA may enhance our understanding of its pathogenesis.
Impact of atmospheric turbulence on the signal intensity of the laser ranging echo of space debris
Authors: Wang Jie , Zhao Yongzhi , Geng Baocun 
Published: November 2024

Based on the research of laser atmospheric transmission theory, this paper derives the laser radar ranging equation under the influence of turbulence under the condition of slant path transmission, and simulates and analyzes the changes in the number of debris laser ranging (DLR) echo photons under different parameters. The results show that the number of echo photons is inversely proportional to the intensity of atmospheric turbulence and proportional to the relative angular spread. The greater the elevation angle, the more echo photons; among them, under strong, weak atmospheric turbulence, and no turbulence conditions, the ratio of the number of echo photons is approximately between 1/500 and 4/5. The success rate of the DLR system detecting effective echo signals under different turbulence intensities is comparatively analyzed. Finally, based on the comparison of the experimental results of the 700 mm DLR system and the simulation results of the corrected model, the average relative error is found to be 13.43%.