bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doppler Ultrasonography on Small Joints of Hands and Feet to Assess Subclinical Affection in Patients with Psoriasis
Authors: Mohamed Maha Shokry , Mohamed Dalia Fayez , Abdelaziz Amina Badr Eldin , El-Azizi Noran Osama Ahmed , Mohamed Elham Shabaan , Ali Hussein Safaa AbdelSalam 
Published: November 2024

Abstract

Background
Psoriasis, a systemic inflammatory disease, often manifests as plaque psoriasis, affecting 80-90% of patients. Psoriatic arthritis (PsA) diagnosis relies on CASPAR criteria, with ultrasound, especially power Doppler, proving valuable in assessing severity and treatment response. PsA causes deformity, dysfunction, and significantly impairs patients' quality of life.

Aim of the Work
To asses subclinical affection of peripheral joints in psoriatic patients without symptoms of arthropathy.

Patients and Methods
A cross-sectional study conducted at Ain Shams University Hospital involved 70 psoriasis patients recruited from dermatology clinics. The study, adhering to ethical standards, utilized comprehensive methods, including medical history, clinical examinations, routine laboratory tests, and musculoskeletal ultrasound with power Doppler. The cross-sectional design allowed assessment of various aspects of psoriasis and its associated conditions.

Results
This cross-sectional study of 70 psoriatic patients revealed that musculoskeletal involvement was more prevalent in females (57.7%) and those with a BMI &gt;24 (kg/m2). Higher PASI scores (&gt;5) correlated with increased risk. Treatment with topical steroids and methotrexate showed positive associations. In multivariate analysis, female gender and PASI score &gt;5 remained significant predictors of musculoskeletal affection in psoriatic patients (p &lt; 0.05).

Conclusion
The study underscores the significance of evaluating musculoskeletal issues in psoriatic patients. Female gender, higher BMI, smoking, and elevated PASI scores were linked to musculoskeletal involvement. Treatment with topical steroids and methotrexate correlated with such issues. Female gender and higher PASI scores were independent predictors of musculoskeletal concerns.
Assessment of Vitamin D Level in Patients with Acute Coronary Syndrome in CCU Patients
Authors: Shoukry Nihad Shoeib , Abdelsalam Mona Mohamed , Abdelsalam Ahmed Mohamed , Ali Hanan Mahmoud , Aoud Mahmoud Said 
Published: November 2024

Abstract

Background
Vitamin D is a steroid hormone that plays a crucial role in mineral homeostasis and bone metabolism. Recent studies have revealed its diverse role in the immune system, vascular and myocardial cells. Vitamin D deficiency and insufficiency are frequently observed in children and adolescents worldwide, particularly in the Middle East. Cardiovascular disease (CVD) is a leading cause of mortality, and ischemic heart disease (IHD) is a major contributor to the global disease burden. The current study aimed to assess the role of vitamin D in IHD patients.

Aim of the Work
Assessment of vitamin D level in patients with acute coronary syndrome.

Patients and Methods
A cross-sectional study was conducted on 90 male patients aged between 40- 60 years old. Patients were divided into two groups based on the presence of diabetes mellitus (DM). Group A comprised of 45 diabetic patients, and Group B included 45 non-diabetic patients. The patients were further divided into four groups based on the presence of acute coronary syndrome (ACS). Group 1 comprised of 23 patients with acute ST-elevation myocardial infarction (STEMI), Group 2 included 22 patients with non-ST elevation acute myocardial infarction (NSTEMI), Group 3 had 23 patients with unstable angina, and Group 4 consisted of 22 patients with stable angina. All patients included in the study provided informed written consent.

Results
The study found that vitamin D insufficiency was prevalent in all ACS and stable angina groups, with the highest vitamin D level observed in Group 4 (stable angina), followed by Group 3 (unstable angina), Group 1 (STEMI), and Group 2 (NSTEMI). A negative correlation was observed between serum vitamin D level and cardiac enzymes CK-MB and troponin. A significant negative correlation was found between serum vitamin D level and age, BMI, and glycemic profile of the studied patients.

Conclusion
In conclusion, the study suggests that vitamin D deficiency and insufficiency are common among Egyptian patients with acute coronary syndrome (ACS) and stable angina, which may increase the risk of developing coronary artery disease (CAD), especially NSTEMI and STEMI. Therefore, vitamin D should be considered as an atypical risk factor for CAD. The incidence of IHD can be controlled by controlling its risk factors such as BMI, age, uncontrolled diabetes, hypertension, and dyslipidemia, which are also associated with low vitamin D levels.
Relationship between Serum Zinc Level and Retinopathy in Type 1 Diabetic Patients
Authors: Eid Yara Mohamed , Ibrahim Wessam Ahmed , Abushady Manal Mohammed , Aly Elhalawany Salah Hussein , Hakim Akhnokh Mary Fayez 
Published: November 2024

Abstract

Background
Diabetes mellitus is one of the common chronic metabolic diseases associated with various micro- and macro-vascular complications. Diabetic retinopathy (DR) is a microvascular disorder with various grades which leads to visual problems or even blindness. Nearly all patients with type 1 diabetes and more than 60% of those with type 2 have some degree of retinopathy after 20 years. Zinc is one of the micro-nutrients abundant in the human body and possess an important role in various metabolic reactions. Previous studies reported that decreased serum zinc levels was associated with certain diabetic microvascular complications. Zinc depletion has a major impact on the pathogenesis of diabetic complications. However, the correlation between zinc level and diabetic retinopathy needed more studies and especially in type 1diabetic patients which has not been studied at all.

AIM/ Objectives
Assess the correlation between serum zinc and diabetic retinopathy in type 1 diabetic patient.

Subjects and Methods
This observational study was conducted on 60 subjects with their ages ranging from 18-60, selected from diabetes outpatient clinics of Ain Shams University Hospitals for 7 months in a period from June 2022 to January 2023; 40 patients and 20 non diabetic as control divided into three groups: 20 Patients with Type 1 diabetes without diabetic retinopathy, 20 Patients with Type 1 diabetes with diabetic retinopathy and 20 apparently healthy individuals. All patients included in the study will be screened for diabetic retinopathy using fundus photography camera. Photos were assessed and graded by an expert ophthalmologist. Assessment of zinc level by automated chemistry analyzer will be done.

Results
The study shows that there was statistically significant negative correlation found between zinc level and duration of diabetes, HbA1c, LDL, TC, FPS, 2PP and serum creatinine level in all diabetic type 1 group. And in groups of patients with and without retinopathy. There was no statistically significant difference found between control group and DM type1 with and without retinopathy group regarding zinc level although there was numerical differences.

Conclusion
Positive relationship between decreased zinc level and diabetic retinopathy suggesting the contribution of this factors in the pathogenesis of DR through acting in a same pathway Further studies using larger numbers of patients are recommended to get benefit of giving zinc supplements to these patients
Role of Serum IGFBP-7 for Diagnosis of Cardiomyopathy in Diabetic Patients vs Healthy Individuals
Authors: El-Shayeb Mohammed Abdelrahman , Ahmed Hoda Mohammed Al-Sayed , Zeyada Omneya Mohamed , Awad Mohammed Rashad , Mahmoud Nassar Mennatullah Nabil Shafik 
Published: November 2024

Abstract

Background
Among the general adult population, it has been estimated that the prevalence of heart failure in diabetic patients ranges from 19% to 26%.

Aim of the Work
This study aims to assess the role of the serum level of IGFBP-7 as a potential biomarker for diagnosis of Diabetic Cardiomyopathy and cardiac fibrosis.

Patients and Methods
Our study was a case control study, conducted on 75 patients of matched age and sex attending Diabetes, Internal Medicine and Cardiology outpatient clinics at Ain Shams university hospital during the period from March 2023 to July 2023. 25 were medically free individuals and they made the control group. As regards the cases group it was divided into further 2 groups where 25 were diabetic patients with normal echo and the remaining 25 patients were diabetic patients with cardiomyopathy.

Results
Our study strongly supports that IGFBP-7 as a biomarker is sensitive enough to detect diabetic cardiomyopathy. BMI was highly significant when compared between diabetic cardiomyopathy and normal Echo and diabetic cardiomyopathy and control group. Linking the correlation between IGFBP-7 and metabolic syndrome. In our study HbA1c was found non-significant between diabetic cardiomyopathy and diabetic normal Echo. Raising the suspicion of correlation between glycemic control and development of Heart Failure. In this study, certain lab parameters such as serum Cr and lipid profile were associated with positive statistical significance in patients with diabetic cardiomyopathy linking the association of diabetic cardiomyopathy with other chronic illnesses such as chronic kidney disease and atherosclerotic diseases.

Conclusion
Our study focused on IGFBP-7 levels to detect the diabetes-induced changes in cardiac structure and function existing at the early stage of DCM, and progression of DCM from subclinical diastolic dysfunction to overt HF. With specificity 100% and sensitivity 68% between diabetic cardiomyopathy and diabetic normal echo. Moreover; with sensitivity 100% and specificity 84% between diabetic normal echo and controls.
Thrombophilia Gene Screen Most Incriminated Factor in Portal Vein Thrombosis in Chronic Liver Disease Patients before Liver Transplantation with Protein C & S Deficiency
Authors: Makhlouf Mohammed Marey , Abd El Aal Amr Ahmad , Abdelrahman Ghada , Raafat Khaled Mohammed , Elsayed Eldemnawy Mennatullah Yasser Elsayed 
Published: November 2024

Abstract

Background
Portal vein thrombosis whether due to inherited or acquired thrombophilia is a major problem prior to liver transplantation & during surgery & post- operative requiruiring prompt diagnosis & management & thrombophilia gene screen is important to identify any inherited cause for thrombophilia as a cause for portal vein thrombosis prior or during or post-surgery or as a cause of any venous thromboembolism in liver transplantation candidate to start proper anti-coagulation when needed.

Aim of the Work
The aim of this study was to determine which factor in thrombophilia gene screen most incriminated in causing portal vein thrombosis in cirrhotic patients prior to liver transplantation.

Patients and Methods
This retrospective study included 40 chronic liver disease patient prior to liver transplantation with protein c &s deficiency,& divided into two groups where group (A) 20 patients have PVT, protein c&s deficiency & mutation in thrombophilia gene screen. And a control group (B) of 20 patients haven’t PVT & have protein c&s deficiency.& patients were collected from Ain Shams University Hospitals.

Results
The results of this study showed that there’s no factor in thrombophilia gene screen shown to be more incriminated in portal vein thrombosis prior to liver transplantation than the other.

Conclusion
It’s not settled yet which factor in thrombophilia gene screen most incriminated in portal vein thrombosis or venous thromboembolism in general, where inherited factors are considered to be low risk factors for thrombosis, yet further studies are needed with larger sample size to determine which factor is most incriminated in portal vein thrombosis prior to liver transplantation.
Study of Leaky Gut syndrome and its Correlation to Hashimoto’s Thyroid Disease with Respect to Antibodies Titre
Authors: Halawa Mohamed Reda , Ahmed Iman Zaky , Eid Yara Mohamed , Youssef Ashour Zeinab Ahmed , Anwar Maha Ahmed , Nesim Mina Michael 
Published: November 2024

Abstract

Background
Hashimoto's thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating auto antibodies against thyroid peroxidase and thyroglobulin. Alterations in the gut microbiota are associated with autoimmune diseases development. There is increasing evidence that gut microbiota is an important environmental factor directly or indirectly influencing the progression of thyroid diseases and that thyroid diseases can exacerbate disturbances in the microbiota

Objective
To evaluate serum zonulin levels and stool lactobacillus acidophilus growth as markers of leaky gut syndrome in patients with Hashimoto's thyroiditis.

Methods
This was a case control study that was conducted on 80 Egyptian subjects age (20 – 60 years old) & were divided into 60 patients with Hashimoto's thyroiditis and 20 control, the patient group was further divided into 3 equal groups according to the thyroid functions state (Euthyroid, sub clinical hypothyroid and overt hypothyroidism), evaluation of serum zonulin and stool lactobacillus acidophilus growth and correlation with TPO antibody titer was done.

Results
Our study showed statistically significant increase in serum zonulin level which was positively correlated to TPO level in Hashimoto's thyroiditis patients implicating a possible presence of leaky gut syndrome, this was present in the hypothyroid group significantly than the Euthyroid Hashimoto's group, as it was also associated with lactobacillus acidophilus stool culture positivity which may reflect a bacterial dysbiosis.

Conclusion
This data may reflect the interaction between the gut microbiota and possible leaky gut syndrome association with Hashimoto’s thyroiditis. However, whether this data is a result from Hashimoto's disease or a cause, this need a further evaluation.
Endoscopic versus Histopathological Diagnosis of Pan-gastritis in Patients with Chronic Gastric Dyspepsia
Authors: Abdelghany Mohamed Mohamed , Elsaid Kadry , Elkhadr Enas , Galal Salah Shaarawy 
Published: November 2024

Abstract

Background
One of the most prevalent, severe, and sneaky chronic disorders in people is chronic gastritis. Numerous hundreds of millions of individuals worldwide may have chronic gastritis in one way or another, according to estimates that more than half of the world's population has this disease to some degree or extent. Despite the clear role of gastritis in the etiology of common peptic ulcers and stomach malignancies, the relevance of chronic gastritis as a dangerous disease is vastly overestimated in clinical practice.

Aim of the Work
to compare the endoscopic diagnosis and histopathologic diagnosis of pan gastritis in patients presented with chronic gastric dyspepsia.

Patients and Methods
This study is a Randomized study conducted at Gastroenterology Medicine outpatient clinic and endoscopy unit in Air Force General Hospital and Benha teaching hospital included 100 patients presented by dyspepsia for more than 8 weeks

Results
In this study we demonstrated that RBCs ranged from 3.8 to 5.9 x1012/L with a mean ± SD of 4.86 ± 0.64 x1012/L. WBCs ranged from 4 to 9.5 x109/L with a mean ± SD of 6.62 ± 1.55 x109/L. Platelets ranged from 120 to 348 x103/µL with a mean ± SD of 224.71 ± 63.94 x103/µL. Hb ranged from 9.5 to 14.5 g/dL with a mean ± SD of 11.83 ± 1.55 g/dL. ALT ranged from 5.9 to 45 U/L with a mean ± SD of 24.34 ± 11.46 U/L. AST ranged from 10.7 to 49 U/L with a mean ± SD of 29.28 ± 10.33 U/L. Urea ranged from 6.5 to 44.7 mg/dL with a mean ± SD of 24.77 ± 10.39 mg/dL. Creatinine ranged from 0.2 to 2.1 mg/dL with a mean ± SD of 1.1 ± 0.6 mg/dL. In this study we illustrated that regarding endoscopic results, 25 (25%) patients were normal, 56 (56%) had gastritis and 19 (19%) had other lesions. regarding patients with gastritis, 7 (12.5%) of them had atrophy, 8 (14.29%) had mucosal nodularity, 24 (42.86%) had edema and 17 (30.36%) had erythema while the location of gastritis varied as 41 (73.21%) patients had pan-gastritis, 9 (16.07%) had antrum predominant gastritis and 6 (10.71%) had corpus predominant gastritis. regarding patients with other lesions, 7 (36.84%) of them had esophagitis, 9 (47.37%) had duodenal ulcer and 3 (15.79%) had hiatal hernia. In this study we illustrated that there was a statistically significant difference among endoscopic and histopathological findings of the studied patients (P value &lt;0.001).

Conclusion
Pan-gastritis is a common finding in early dyspeptic patients and endoscopy has high sensitivity in diagnosis of pangastritis and normal endoscopic appearance did not rule it out, and the histopathology was still the gold standard method.
Role of Soluble Transferrin Receptor and Transferrin Receptor-Ferritin Index to Detect Iron Deficiency Anemia in Regular Hemodialysis Patients
Authors: Abd Elmageed Khaled Hamdy , Allam Ahmed Samir , Abdo Samy Mahmoud , Elshony Mustafa Salah Mustafa 
Published: November 2024

Abstract

Introduction
Several iron indicators can be used to detect iron deficiency anaemia (IDA) where confounding comorbidities occurred such as patients with regular hemodialysis.

Aim of the Study
to determine the diagnostic value of sTfR and TfR-F and to combine these two markers in detecting IDA in HD anemic patients.

Patients and Methods
This is observational prospective case–control study carried on 30 cases &30 controls. IDA was diagnosed based on TS &lt; 20% and ferritin level &lt; 200 ng/L and functional iron deficiency when TS &lt; 20% and ferritin &gt; 200 ng/L. TfR-F index calculated as sTfR/log ferritin. All participants were subjected to full clinical examination& routine laboratory investigations (CBC, RBCs indices, iron profile, serum electrolytes blood urea and creatinine) specific investigations (Serum sTfR was measured with ELISA technique)

Results
There is statistically significant difference between the two groups as regard sTfR. There were strong significant correlations between TfR-F index and T.SAT, CRP, TIBC and sTfR. In Univariate correlation regression, there were strong significant positive correlations between TfR-F index and T.SAT, CRP, TIBC and sTfR. In Multivariate correlation regression, there were strong significant positive correlations between TfR-F index and T.SAT, CRP, TIBC and sTfR. Sensitivity of sTfR and TfR-F index was 83.5% and 85% respectively. Specificity of sTfR and TfR-F index was 70.1% and 75% respectively.

Conclusion
When sTfR and the TfR-F index used in combination to detect IDA, we found that sensitivity of sTfR and TfR-F index was 83.5% and 85% respectively. Specificity of sTfR and TfR- F index was 70.1% and 75% respectively.
Impaired Intestinal Barrier Function in Immune Thrombocytopenic Purpura Patients Measured by Serum Zonulin
Authors: Nour Melek Nermine Abd-El , Kamal Tanagho Sylvia Talaat , Mehriz Ali Salem Lamyaa Elsayed , Mettias Tacla Nermine Moheb , El-Mekawey Mohamed Nada Ragab 
Published: November 2024

Abstract

Background
Besides its involvement in the digestion and resorption of nutrients, one task of the intestine is to act as a barrier regulating the passage of antigens and macromolecules from the environment into the organism. This barrier is to a major extent formed by the intestinal epithelia and its lateral tight junctions whichclose off the paracellular interstices. The tight junctions consist of transmembrane barrier proteins such as occludin and claudins, which are bound via proteins of the intracellular cytoskeleton with actin and microtubular structures. The function of the intestinal barrier (IB) can be modulated by a variety of stimuli. These include nutrients such as gluten, toxins or bacteria or their respective metabolic products ab- sorbed with the nutrition which induce a raised secretion of zonulin through the cells of the lamina propria.

Objective
To evaluate serum Zonulin level, as a marker of increased intestinal permeability, in ITP patient compared to healthy subjects.

Methods
This Study was conducted between October 2022 and June 2023 on 60 patients diagnosed with ITP divided in to 2 sub-groups 30 patients on steroid therapy for a duration longer than 3 months and 30 steroid naïve patients togetherwith 30 apparently healthy individuals as a control group. Patients were recruitedfrom Hematology department and outpatient clinic, Ain Shams University Hospitals.

Results
There was highly statistically significant difference between chronic patients and newly diagnosed patients regarding PLT and Serum Zonulin p &lt; 0.001. There was highly statistically significant difference between recently diagnosed patients and healthy controls regarding PLT p &lt; 0.001, there was statistically significant difference regarding ALT and Serum Zonulin, (p value were 0.03 and 0.01) respectively. There was a statistically significant correlation among all study participants between Serum Zonulin and Creatinine, p value = .004. There was no statistically significant correlation among all study participants between Serum Zonulin and TLC, HB, PLT and ALT, (p value were 0.736, 0.227, 070 and 0.619) respectively. There was highly statistically significant correlation between serum zonulin level and PLT in chronic patients, p value &lt;0.001.

Conclusion
There was highly statistically significant difference between three study groups regarding PLT and Serum Zonulin. There was a statistically significant correlation among all study participants between Serum Zonulin and Creatinine. There was highly statistically significant correlation between serum zonulin level and PLT in chronic patients.