bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning for low-frequency extrapolation from multioffset seismic data
Authors: Ovcharenko Oleg , Kazei Vladimir , Kalita Mahesh , Peter Daniel , Alkhalifah Tariq 
Published: September 2019

Low-frequency seismic data are crucial for convergence of full-waveform inversion (FWI) to reliable subsurface properties. However, it is challenging to acquire field data with an appropriate signal-to-noise ratio in the low-frequency part of the spectrum. We have extrapolated low-frequency data from the respective higher frequency components of the seismic wavefield by using deep learning. Through wavenumber analysis, we find that extrapolation per shot gather has broader applicability than per-trace extrapolation. We numerically simulate marine seismic surveys for random subsurface models and train a deep convolutional neural network to derive a mapping between high and low frequencies. The trained network is then tested on sections from the BP and SEAM Phase I benchmark models. Our results indicate that we are able to recover 0.25 Hz data from the 2 to 4.5 Hz frequencies. We also determine that the extrapolated data are accurate enough for FWI application.
Long-term outcomes of trials in the National Institute for Health and Care Excellence depression guideline
Authors: McPherson Susan , Hengartner Michael P. 
Published: September 2019

Summary
The forthcoming National Institute for Health and Care Excellence depression guideline reviews short-term outcomes for long-term depression. We present effect sizes for long-term outcomes in trials that report these data. Psychological therapies become more effective, whereas antidepressants become less effective over the long term. We review other forms of longitudinal research that support these findings.
Effect of Different Concentrations of Propofol Used as a Sole Anesthetic on Pupillary Diameter: A Randomized Trial
Authors: Sabourdin Nada , Meniolle Fleur , Chemam Sarah , Rigouzzo Agnes , Hamza Jamil , Louvet Nicolas , Constant Isabelle 
Published: September 2019

BACKGROUND:
Pupillometry monitoring under general anesthesia is based on the assumption that pupillary diameter variations reflect the adequacy of the provided analgesia to the intensity of the nociceptive surgical stimulus. The accurate interpretation of pupillometric data requires establishing clearly what the expected baseline unstimulated pupillary diameter at each specific level of hypnosis is. Opioids decrease pupillary diameter in a dose-dependent fashion. In contrast, the effects of hypnotic drugs on pupillary diameter are not well known. Our aim was to describe the potential relationship between propofol predicted effect-site concentrations (Cets) ranging from 1 to 3 µg/mL and pupillary diameter.

METHODS:
Patients were randomized to receive propofol by target-controlled infusion at a predicted Cet of 1, 2, or 3 µg/mL (groups P1, P2, and P3, respectively). Pupillary diameter measurements were performed after 10 minutes of steady-state propofol infusion at the randomized Cet. No stimulation was performed during the study. Heart rate and bispectral index (BIS) were continuously recorded.

RESULTS:
Forty patients were included: (13, 14, and 13 in groups P1, P2, and P3, respectively). Mean pupillary diameter was 5.7 mm (1 mm) in group P1, 4.8 mm (1.3 mm) in group P2, and 3.3 mm (0.8 mm) in group P3. Propofol had a dose-dependent effect on pupillary diameter (linear regression R
2 = 0.45, P < .001). Pupillary diameter was positively correlated with the BIS (Spearman r = 0.75 [95% confidence interval (CI), 0.54 to −0.87] P < .001).

CONCLUSIONS:
From 1 to 3 µg/mL of predicted Cet, propofol has a dose-dependent effect on pupillary diameter. Within this concentrations range, there is a positive correlation between BIS and pupillary diameter. The subcortical effect of propofol on pupillary diameter is correlated to its effect on the cortex. Studies assessing pupillary diameter as a marker of the nociception–antinociception balance should be performed in patients with a standardized depth of hypnosis.
Whole Blood Point-of-Care Testing for Incomplete Reversal With Idarucizumab in Supratherapeutic Dabigatran
Authors: Takeshita Shusuke , Tanaka Kenichi A. , Sawa Teiji , Sanda Masashi , Mizobe Toshiki , Ogawa Satoru 
Published: September 2019

BACKGROUND:
Incomplete reversal with a recommended 5-g dose of idarucizumab has been reported in patients with excessively high dabigatran concentrations. A timely detection of reversal failure after idarucizumab using whole blood (WB) coagulation testing is clinically useful. The aims of this study were to determine residual dabigatran activity after idarucizumab on thrombin generation (TG) using in vitro supratherapeutic dabigatran models and to compare 4 WB point-of-care tests (activated partial thromboplastin time [aPTT], prothrombin time [PT], and 2 thromboelastometry tests) with the TG results.

METHODS:
Blood samples from 12 healthy volunteers were spiked in vitro with 0–5000 ng/mL of dabigatran. Dabigatran reversal was evaluated by adding 1000 μg/mL of idarucizumab (Praxbind) to dabigatran-spiked samples, which reflect the administration of 5-g idarucizumab to a 70-kg patient. Residual dabigatran activity was assessed using the calibrated automated TG (Thrombinoscope) in platelet-poor plasma samples. The TG results were compared with WB aPTT (DRIHEMATO APTT-S) and PT (DRIHEMATO PT-S) using CG02N analyzer, thromboelastometry (ROTEM) triggered by ellagic acid (INTEM) and tissue factor (EXTEM).

RESULTS:
At a therapeutic concentration of dabigatran (200 ng/mL), the lag time was prolonged, and peak TG was decreased. The effects of dabigatran on TG were increased up to 1000 ng/mL, and TG was obliterated at higher supratherapeutic dabigatran levels (P < .001 versus control, respectively). TG was fully restored with idarucizumab when dabigatran was ≤2000 ng/mL, but residual anticoagulant activity was observed at higher dabigatran levels. Dabigatran prolonged WB aPTT and PT concentration dependently, and residual prolongations were observed when idarucizumab was added to 3000 or 5000 ng/mL of dabigatran (P < .001 versus control, respectively). In contrast, both INTEM and EXTEM clotting times were reversed toward reference ranges at all dabigatran concentrations when idarucizumab was added.

CONCLUSIONS:
Our data indicate that the recommended dose of idarucizumab may not restore TG completely with excessively elevated concentrations of dabigatran. All WB measurements with aPTT, PT, and thromboelastometry predicted supratherapeutic dabigatran concentrations, whereas those tests varied in sensitivity to residual anticoagulant activity after reversal. WB aPTT corresponded well with plasma TG changes among those measurements, but the use of thromboelastometry may overestimate the effect of idarucizumab. Caution should be exercised before extrapolating in vitro point-of-care data to the clinical monitoring of dabigatran reversal.
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair
Authors: Khouj Ebtissal M. , Prosser Suzanna L. , Tada Haruto , Chong Weng Man , Liao Jung-Chi , Sugasawa Kaoru , Morrison Ciaran G. 
Published: September 2019

ABSTRACT
Centrin 2 is a small conserved calcium-binding protein that localizes to the centriolar distal lumen in human cells. It is required for efficient primary ciliogenesis and nucleotide excision repair (NER). Centrin 2 forms part of the xeroderma pigmentosum group C protein complex. To explore how centrin 2 contributes to these distinct processes, we mutated the four calcium-binding EF-hand domains of human centrin 2. Centrin 2 in which all four EF-hands had been mutated to ablate calcium binding (4DA mutant) was capable of supporting in vitro NER and was as effective as the wild-type protein in rescuing the UV sensitivity of centrin 2-null cells. However, we found that mutation of any of the EF-hand domains impaired primary ciliogenesis in human TERT-RPE1 cells to the same extent as deletion of centrin 2. Phenotypic analysis of the 4DA mutant revealed defects in centrosome localization, centriole satellite assembly, ciliary assembly and function and in interactions with POC5 and SFI1. These observations indicate that centrin 2 requires calcium-binding capacity for its primary ciliogenesis functions, but not for NER, and suggest that these functions require centrin 2 to be capable of forming complexes with partner proteins.
This article has an associated First Person interview with the first author of the paper.
Postnatal debriefing: women's need to talk after birth
Authors: Baxter Jackie 
Published: September 2019

Background There is a lack of evidence of the clinical benefit of postnatal debriefing, but qualitative studies show that women value talking to a midwife after birth. However, a very small proportion of women accepted a postnatal discussion meeting at the district general hospital where the author worked. Aim To determine why some women need to talk to a professional after giving birth. Method A postal survey was sent to a sample of 447 women who gave birth during one calendar month at an NHS Trust in England. This instrument also included the impact of events scale (IES), which assessed women's feelings in relation to their recent experience of giving birth. A total of 170 women (38%) returned the completed form. Findings Some women need to talk about their birth experience after they have left the hospital. Women with symptoms of post-traumatic stress (PTS), measured by a high IES, were more likely to want to talk after giving birth and more likely to rate their experience of birth negatively, compared with those with a low IES. Approximately one-third of women who responded experienced high PTS symptoms. Conclusions Maternity providers should consider offering a postnatal listening service to meet women's needs in relation to understanding their experience of giving birth. This will also serve to identify women with PTS symptoms and offer further support.
The influence of poverty on children’s school experiences: pupils’ perspectives
Authors: Naven Lynn , Egan James , Sosu Edward M. , Spencer Sara 
Published: September 2019

This study examined the potential influence of policies and practices on the ability of children from low-income families to participate fully in the school day. Pupils from six schools participated in 71 focus groups and revealed a range of barriers affecting their school experience: transport costs and limited support; clothing costs, stigma and enforcement of school dress codes; material barriers to learning at school and home; concerns about free school meals; missing out on school trips, clubs and events.
Findings on school uniform were an important catalyst towards a recent policy change in Scotland in increasing the school clothing grant.
Methodologies for Plasmopara halstedii Research
Authors: Martínez Ana Laura , Anderson Freda , Quiroz Facundo , Garayalde Antonio , Erreguerena Ignacio , Armando Lorena , Huguet Norma , Carrera Alicia 
Published: September 2019

Abstract
The objective of this work was to find practical procedures to overcome methodological drawbacks encountered during studies on sunflower downy mildew. Techniques for recovering living isolates of Plasmopara halstedii from the field and for the preservation of infected leaf samples for further molecular analysis were developed. A Polymerase Chain Reaction (PCR)-based test for the detection of P. halstedii in sunflower leaves and a method to remove azoxystrobin from fungicide-treated seeds are proposed. In situ-inoculations of pre-germinated seeds allowed the recovery of living isolates from the field. Three sample-preservation methods were evaluated (silica, heating and lyophilization) resulting in high yield and quality of the DNA extract. It was detected the presence of the pathogen in symptomless leaves through PCR using molecular markers based on expressed sequence tags. A treatment using sodium hypochlorite is recommended for the removal of azoxystrobin from fungicide treated seeds.
Comparison of the effect of self-care education in a disaster with two student-centered and family-centered approaches to self-care in students
Authors: Eskandari Ali , Motaghi Minoo 
Published: September 2019

Abstract

Objectives
The purpose of this research was to compare the effect of self-care education in disasters with two student-centered and family-centered approaches to self-care in students of the Red Crescent Societies in the city of Lenjan in 2017.

Methods
One hundred and fifty individuals were selected by random sampling from 270 people. The research instrument was a questionnaire. The questionnaire was approved by the opinion of supervisors and other experts. The present research is a quasi-experimental study. The covariance analysis was used to determine the difference between the two groups in the experimental and control groups and the effect of educational intervention. All of the above steps were performed using the SPSS 23 statistical program.

Results
The results indicate that there is a significant difference between the two groups in self-care through the student-centered approach. The mean of the self-care group with a family-centered approach (21.72) was more than the mean of the control group in this variable (16.61). Moreover, the mean of the self-care group’s education with family-centered approaches (42.61) was more than the mean of self-care education h in a disaster with a student-centered approach (31.23).

Conclusion
According to the results of this study, it can be concluded that there is a significant difference between self-care education with two student-centered and family-based approaches to self-care in students, and a family-centered approach has better outcomes.
Preserving Artworks Digitally: The Case of Andy Warhol’s Polaroid Photographs
Authors: Botticelli Peter 
Published: September 2019

AbstractAs museum objects are digitized, curators will need to examine closely the potential for digital objects to represent, and possibly distort, the authentic information contained in material objects. This work examines the complex preservation issues facing Polaroid photographs by Andy Warhol, as a case example of a distributed collection of relatively fragile, non-reproducible photographs which have recently been digitized, but with uncertain consequences for how audiences might experience the Polaroids in digital form. With the potential for digital objects to outlast the Polaroids, this work highlights the need for rich documentation to ensure that digital representations might be able to serve as a practicable preservation medium for material objects.
Simulation of dynamic mold compression and resin flow for force-controlled compression resin transfer molding
Authors: Chang Chih-Yuan 
Published: September 2019

Abstract
In the present study, an improved consolidation model, with mold inertia included, is proposed to completely predict how the upper mold rapidly moves from rest to maximal velocity and then decelerates to a steady value for a constant force-controlled compression resin transfer molding (CRTM). Simulation results show that all preform compaction cases cannot apply to quasi-static consolidation theory in CRTM. For cases with a massy mold, inadequate preform resistance, and low resin viscosity, the mold inertia has a short, remarkable influence on the resin counter-force and causes a slightly slow resin progression in the early compression stage. Contrarily, the compaction of the rigid preform is applicable to the quasi-static consolidation theory. Additionally, a reasonable time increment is discussed for using the quasi steady-state approximation.
Aromatase (CYP19) inhibition by biflavonoids obtained from the branches of Garcinia gardneriana (Clusiaceae)
Authors: Recalde-Gil Angelica Maria , Klein-Júnior Luiz , Salton Juliana , Bordignon Sérgio , Cechinel-Filho Valdir , Matté Cristiane , Henriques Amélia 
Published: September 2019

Abstract
Overexpression of aromatase in breast cancer cells may substantially influence its progression and maintenance. In this sense, the inhibition of aromatase is a key target for the treatment of breast cancer in postmenopausal women. Although several flavonoids had already demonstrated the capacity of inhibiting aromatase activity, the role of biflavonoids as aromatase inhibitors is poorly studied. In this work, the biflavonoids isolated from Garcinia gardneriana, morelloflavone (1), Gb-2a (2) and Gb-2a-7-O-glucose (3) were submitted to in vitro assay to evaluate the aromatase modulatory effect. As results, it was demonstrated that all biflavonoids were able to inhibit the enzyme, with IC50 values ranging from 1.35 to 7.67 μM. This demonstrates that biflavonoids are an important source of scaffolds for the development of new aromatase inhibitors, focusing on the development of new anticancer agents.
FORMULATION OF MINERBA LAW ENFORCEMENT POLICY AGAINST UNCONVENTIONAL MINE FLOATING CATEGORY (STUDY OF SOCIO LEGAL IN BANGKA DISTRICT)
Authors: Rahayu Derita Prapti , YOKOTANI YOKOTANI , Toni Toni 
Published: September 2019

The floating TI problem will also have an impact on policies on environmental conservation, fisheries and cultural change. Subjectivity of policy issues. This research approach is socio-legal. Research with such an approach, views the law in its complex face, not only stops at the norm, but also targets how the process of formation is up to its implementation. TI floating problems must be identified related to issues of authority, economic and environmental issues. With this concept, this research was carried out by conducting a step review of norms for the first stage. In the next stage, a search for certain norms related to floating TI is carried out the act of number 4 ‘ 2009 on Minerals and Coal. It was only analyzed by offering how floating law enforcement related to IT in the Bangka Regency area. Policy problems are only possible when humans make judgments about the desire to change some problem situations. The policy problem is the result / product of human subjective assessment, the policy problem can also be accepted as legitimate definitions of objective social conditions and hence policy problems are understood, maintained and changed socially; and there are many solutions to a problem as there are many definitions of the problem. Problems and solutions are in constant changes.
BUILDING DIMENSIONAL DEVELOPMENT IN MANAGING COMPLETION OF FREEDOM OF RELEGIOUS AND BELEIF CONFLICT IN INDONESIA
Authors: Fidiyani Rini 
Published: September 2019

Rini FidiyaniFakultas Hukum Universitas Negeri SemarangEmail fidiyani.rini@gmail.comErni Wulandari, S.H., M.HumMahasiswa Program Doktor Ilmu HukumUniversitas Sebelas Maret – SoloEmail erniwulandari.006@gmail.com Abstrak Pendidikan tinggi hukum memiliki sejarah panjang di Indonesia dari masa colonial Hindia Belanda sampai masa sekarang. Peletakan dasar pendidikan tinggi hukum berawal dari pendidikan menengah hukum – Rechtscholl - bagi tenaga kerja Bumi Putera yang dijadikan pegawai ambtenaar yang dibayar murah. Tugas lulusan Rechtscholl membantu pekerjaan aparat hukum dari golongan penduduk Eropa, khususnya Belanda. Atas tuntutan politik etis dan menggema konsep negara nasionalis merdeka dari segala bentuk kolonialisme, pemerintah Kolonial Hindia Belanda membuka pendidikan tinggi hukum yang berlanjut hingga sekarang. Sekarang kita telah memasuki pendidikan tinggi hukum yang bersinggungan dengan kompleksitas globalisasi menyangkut beraneka kebutuhan dan masyarakat serta area. Tuntutan pendidikan tinggi hukum masa sekarang bukan sekedar mencetak sarjana hukum yang mahir menyusun berdokumen hukum sebagai kemahiran hardskill bahkan meluas sampai pada softskill dalam mengelola penyelesaian konflik menyangkut kepekaan social, rasa empati, sikap disiplin dan kesetaraan berkomunikasi dengan pihak yang berkonflik. Konflik Kebebasan Beragama dan Berkeyakinan di negara Indonesia rentan terjadi sehubungan masyarakat kita merupakan heterogen dan kasus konflik sudah terbukti menyebar di Indonesia. Seperti konflik Gerakan Aceh Merdeka, Papua, Poso. Profil memiliki kemahiran berdialog merupakan kemahiran softskill yang wajib dikuasi bagi lulusan pendidikan tinggi hukum dalam mengelola penyeleaian sengketa hukum dan atau konflik yang sekarang mudah muncul dalam berbagai sector kehidupan salah satunya kebebasan beragama dan berkeyakinan. Kemahiran personal dialogonal membutuhkan modal dan latihan khusus yang terarah dan berkesinambungan dalam membangun kemahiran tersebut. Salah satunya dalam pengelolaan penyelesaian konflik kebebasan beragama berkeyakinan di Indonesia sekaligus peluang baru dalam profesi bagi lulusan pendidikan tinggi hukum.Kata Kunci: konflik, kebebasan beragama berkeyakinan, personal dialogonal
Venture Capital Regulation Reform: Revitalization of Venture Capital as an Alternatives Financing Mentorship and Partnership Based
Authors: Abubakar Lastuti , Handayani Tri 
Published: September 2019

The growth of Venture Capital Company (PMV) in Indonesia is progressive although not significant. The Characteristics of Venture Capital, which is temporary in equity participation, caused venture capital financing is being highly risky financing. To anticipate this risk, PMVseeks the Investee Company (PPU) as a partner who is obliged to return capital. This is to secure this investment by using the concept of financing by venture capital. In addition, a guarantee agreement can be executed if Investee Company did not carry out obligations. This research aims to examine and analyze the essence of venture capital as an alternative financing mentorship and partnership based. In addition, it examines the position of collateral in financing venture capital. This study uses a normative juridical approach with descriptive analytical research specifications and qualitative juridical analysis. The initial concept financing of venture capital as equity participation that using mentorship and partnership turns into loan based financing with collateral. The regulations reform of venture capital through OJK Regulation is aim to expand the objectives of Venture Capital as an effort to anticipate the development of technology based and start up business. In addition, regulation reform of on Venture Capital aims to strengthen venture Capital through the authority of PMV/PMVSto manage Venture Fund. Legal reform of Venture Capital must be interpreted and implemented in line with the purposes of venture Capital as an alternative financing that prioritizes mentorship and partnership between PMV/PMVSand PPU. Beside the supervision by the OJK, the Venture Capital Agreement is an instrument to empower Venture Capital for MSMEs financing optimally. Keywords: revitalization of venture capital; law reform of venture capital; financing mentorship based