bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profil Minyak Biji dari Empat Varietas Rosela Herbal (Hisbiscus sabdariffa var. sabdariffa) Indonesia
Authors: Nurnasari Elda , Anggraeni Tantri Dyah Ayu , Nurindah Nurindah 
Published: September 2019

<p>Rosela herbal dibudidayakan untuk diambil kalik (kelopak bunga) sebagai bahan baku minuman herbal. Produk samping dari budidaya rosela herbal salah satunya adalah biji rosela. Penelitian ini dilakukan untuk mengevaluasi komposisi senyawa asam lemak dan kadar minyak biji rosella dari empat varietas unggul rosella herbal (Roselindo 1, Roselindo 2, Roselindo 3, dan Roselindo 4 dan membahas potensinya sebagai bahan pangan). Minyak biji rosella herbal diekstrak dengan cara pengepresan dan analisa profil asam lemak dengan metode GCMS. Biji rosela herbal mempunyai kadar minyak yang cukup tinggi, yaitu antara 23,25 – 27,31%. Asam linoleat, asam oleat, asam palmitat dan asam nonadekanoat adalah asam lemak utama pada empat varietas rosela herbal. Pengelompokan varietas rosela berdasarkan persentase kemiripan kandungan minyak dan asam lemak menunjukkan bahwa Roselindo 1 berada dalam satu kelompok dengan Roselindo 3 dan Roselindo 2 dengan Roselindo 4. Senyawa asam lemak dari Roselindo 1 dan Roselindo 3 asam adalah dari kelompok asam lemak tak jenuh (UFA) yakni asam linoleat pada Roselindo 1 dan asam oleat pada Roselindo 3. Senyawa asam lemak utama varietas Roselindo 2 dan Roselindo 4 adalah asam nonadekanoat. Berdasarkan jenis asam lemak tersebut maka minyak biji rosella termasuk dalam kategori minyak yang aman dikonsumsi (<em>edible oil</em>) dan juga berkhasiat bagi kesehatan.</p><div><hr align="left" size="1" width="33%" /><div><p align="center"><strong>Profile of Four <strong>Varieties of </strong>Indonesian Herbal Roselle (<em>Hisbiscus sabdariffa</em> var. <em>sabdariffa</em>) </strong></p><p>Herbal roselle is cultivated for calices production as raw material for herbal drinks. One of the by products from herbal roselle cultivation is roselle seeds. This study was conducted to evaluate the composition of fatty acid compounds and roselle seed oil content of four herbal roselle superior varieties (Roselindo 1, Roselindo 2, Roselindo 3, and Roselindo and discuss their potency as a foodstuff 4). Herbal roselle seed oil is extracted using pressing method and analyzing fatty acid profiles using GC-MS method. Herbal roselle seeds have high oil content, i.e., 23.25 - 27.31%. Linoleic acid, oleic acid, palmitic acid and nonadecanoic acid are the main fatty acids in four herbal rosela varieties. The grouping of rosela varieties based on the percentage similarity of oil content and fatty acids shows that Roselindo 1 is in one group with Roselindo 3 and Roselindo 2 with Roselindo 4. The main fatty acids of Roselindo 1 and Roselindo 3 are from a group of unsaturated fatty acids (UFA), namely linoleic acid on Roselindo 1, and oleic acid in Roselindo 3 The main fatty acid compounds of Roselindo 2 and Roselindo 4 are nonadecanoic acid. Based on these types of fatty acids, rosella seed oil of Roselindo varieties is in the category of edible oil and is also beneficial for health.</p></div></div>
Akar Teologis Etos Kerja Jamaah Tabligh Studi Kasus Komunitas Jamaah Tabligh Desa Temboro Kecamatan Karas Magetan
Authors: Munir Ahmad 
Published: August 2019

Salah satu janji agama adalah kebahagiaan bagi pengikutnya. Janji tersebut diterjemahkan sesuai dengan mindstreem masing-masing. Salah satunya adalah Jamaah Tabligh. Jamaah Tabligh menyatakan dirinya sebagai komunitas yang netral dalam bermadzhab, ber-ormas, dan berpolitik, tetapi dalam bingkai ahl al-sunnah wa aljamâ’ah. Mereka lebih menonjolkan aktivitas keberagamaannya secara riil melalui praktik dakwah dengan mengedepankan akhlaq. Menurut Jamaah Tabligh tujuan hidup adalah untuk beribadah, sebagai khalifah, dan untuk berdakwah. Realitas di lapangan menunjukkan bahwa Jamaah Tabligh memiliki etos kerja yang kuat dan ulet. Berdasarkan hal tersebut dirumuskan pertanyaan, bagaimana pandangan mereka terhadap kerja, ikhtiyar, dan tawakkal serta faktor-faktor yang melingkupinya. Pertanyaan tersebut dijawab dengan menggunakan logika induktif dengan menggunakan pendekatan kualitatif melalui analisis dan pemaknaan data lapangan yang telah diorganisir dengan sistematis untuk menemukan makna yang terdalam (deep-meaning) di balik realitas yang ada. Hasil penelitian menunjukkan bahwa pola hidup Jamaah Tabligh didasarkan pada pemahaman konsep keagamaan yang dipegangi, yaitu enam sifat shahabat. Dari pemahaman tersebut, mereka berkeyakinan bahwa rizki dan keperluan hidup telah ditentukan Allah. Tetapi manusia wajib untuk mencari dan mengupayakan. Mereka memandang materi sebagai bagian yang tak terpisahkan dalam kehidupan, tetapi bukan menjadi tujuan hidup. Dari konsep pemahaman tersebut sekaligus menjadi dasar dalam berinteraksi dan berakulturasi dengan suasana yang baru. Akhirnya proses yang dilakukan dapat dimanfaatkan dan membentuk iklim kompetisi yang sehat dan berakhir dengan kemakmuran dan keharmonian kehidupan.
The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010-2013: A multicity study
Authors: Xu Zece , Hu Wenqi , Jiao Kedi , Ren Ci , Jiang Baofa , Ma Wei 
Published: August 2019

Abstract
Background Hand, foot and mouth disease (HFMD) is a serious infectious disease, which has become a public health problem. Previous studies have shown that temperature may influence the incidence of HFMD, but most only focus on single city and the results are highly heterogeneous. Therefore, a multicity study was conducted to explore the association between temperature and HFMD in different cities and search for modifiers that influence the heterogeneity. Methods We collected daily cases of childhood HFMD (aged 0-5 years) and meteorological factors of 21 cities in Guangdong Province in the period of 2010-2013. Distributed lag non-linear model (DLNM) with quasi-Poisson was adopted to quantify the effects of temperature on HFMD in 21 cities. Then the effects of each city were pooled by multivariate meta-analysis to obtain the heterogeneity among 21 cities. Potential city-level factors were included in meta-regression to explore effect modifiers. Results A total of 1,048,574 childhood cases were included in this study. There was a great correlation between daily childhood HFMD cases and temperature in each city, which was non-linear and lagged. High heterogeneity was showed in the associations between temperature and HFMD in 21 cities. The pooled temperature-HFMD association was peaking at the 79th percentile of temperature with relative risk (RR) of 2.474(95%CI: 2.065-2.965) as compared to the median temperature. Latitude was the main modifier for reducing the heterogeneity to 69.28% revealed by meta-analysis. Conclusions There was a strong non-linear and lagged correlation between temperature and HFMD. Latitude was strongly associated with the relationship between temperature and HFMD. Meanwhile, it had an effect on modifying the relationship. These findings can conducive to local governments developing corresponding preventive measures.
Current states of prevention of drug-induced gastroduodenal ulcer in clinical real practice
Authors: Iwamoto Junichi , Monma Tadakuni , Ueda Hajime , Tamamushi Makoto , Konishi Naoki , Yara Shoichiro , Murakami Masashi , Hirayama Takeshi , Honda Akira , Ikegami Tadashi , Mizokami Yuji 
Published: August 2019

Abstract
Background and Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) are the most common causes of drug-induced gastroduodenal ulcer. We investigated preventive treatment with use of concomitant anti-ulcer drugs and the clinical features of gastroduodenal ulcer in cases treated with these drugs.Method: A total of 2,332 patients with gastroduodenal ulcer and 241 patients with bleeding gastroduodenal ulcer were classified into 3 groups: those taking LDA, those taking non-aspirin NSAIDs (hereinafter referred to as NSAIDs), and those taking neither aspirin nor NSAIDs. Chronological changes in the percentage of each group and the change over the past 15 years were investigated. The status of prevention of ulcer and clinical features were examined in 264 patients with gastroduodenal ulcer taking NSAIDs or LDA, including 107 bleeding cases, in the past 8 years.Results: From January 2002 to December 2017, the percentage of all patients taking LDA increased until 2013, but from 2014, the percentage of patients taking LDA decreased in those with a bleeding ulcer. The percentage of patients taking NSAIDs decreased from 2002 in those with a bleeding ulcer. Among the 264 patients with gastroduodenal ulcer and the 107 patients with a bleeding ulcer taking NSAIDs and LDA, 16 (6%) and 9 (8%), respectively, were receiving preventive treatment with concomitant anti-ulcer drugs. The percentages of patients taking LDA and other antiplatelet drugs in patients with bleeding gastroduodenal ulcer were significantly higher than those in patients with non-bleeding. Conclusion: Although the percentages of patients with gastroduodenal ulcer taking NSAIDs or LDA have not recently increased in real-world practice, preventive treatment in these patients is still low. This low rate of prevention in cases of non-bleeding and bleeding gastroduodenal ulcer suggests the need to enlighten physicians about preventive treatment because drug withdrawal of LDA has a high risk of cardiovascular and cerebrovascular events
Differences in results and related factors between Hospital-at-Home modalities in Catalonia: a cross sectional study
Authors: Torre Jorge Arias de la , Zioga Evangelia Anna María , Macorigh Lizza , Muñoz Laura , Estrada Oriol , Mias Montse , Estrada Maria-Dolors , Puigdomenech Elisa , Valderas Jose M , Martín Vicente , Molina Antonio J , Espallargues Mireia 
Published: August 2019

Abstract
Background

Hospital-at-home (HaH) is a healthcare modality that provides active treatment by healthcare staff in the patient’s home for a condition that would otherwise require hospitalization. Previous studies have described two basic types of HaH: hospital admission avoidance and early discharge The aims of this study were: To describe the characteristics of different types of hospital-at-home (HaH) contacts; to assess readmission, mortality, and mean length of stay for each HaH modality; and to examine which factors could be related to these results.

Methods

A cross-sectional study based on data from all 2014 HaH contacts from Catalonia was designed. The following HaH modalities were considered: admission avoidance (n=7,214; 75.1%) and early discharge (n=2,387; 24.9%). The main outcome indicators were readmission, mortality, and mean length of stay (days). Contact characteristics were compared at bivariable level and indicators were calculated for each HaH modality. Multivariable General linear models were fitted to assess the association between explanatory factors and outcomes.

Results

Differences in contact characteristics between HaH modalities were observed at bivariable level. In the hospital avoidance modality there were 8.3% readmissions, 0.9% mortality, and a mean length of stay (SD) of 9.6 (10.6) days. In the early discharge one, these figures were 7.9%, 0.5%, and 9.8 (11.1), respectively. In both modalities, readmission and mean length of stay were related to comorbidity and type of hospital, and mortality with age.

Conclusions

The results show that the HaH results in Catalonia are acceptable and similar to those observed in other contexts. The factors related to these results could help improve the effectiveness and efficiency of the different HaH modalities.
The Cost-effectiveness of screening tools used in the diagnosis of fetal alcohol spectrum disorder: A modeled analysis
Authors: berrigan patrick , Andrew Gail , Reynolds James N , Zwicker Jennifer D 
Published: August 2019

Abstract
Background Fetal Alcohol Spectrum Disorder (FASD) is characterized by physical and neurological abnormalities resulting from prenatal alcohol exposure. Though diagnosis may help improve patient outcomes, the diagnostic process can be costly. Subsequently, screening children suspected of FASD prior to diagnostic testing has been suggested, to avoid administering testing to children who are unlikely to receive a diagnosis. The present study set out to assess the cost-effectiveness of currently recommended FASD screening tools.Methods The screenings tools evaluated were chosen from Children’s Healthcare Canada’s National Screening Toolkit for Children and Youth Identified and Potentially Affected by FASD and include meconium testing of fatty acid ethyl esters (meconium testing) and the neurobehavioral screening tool (NST). An economic model was constructed to assess cost-effectiveness. One-way and probabilistic sensitivity analyses were conducted to assess the robustness of findings. Costs reflect 2017 Canadian dollars and the perspective is the public healthcare system. Results Both screening tools evaluated resulted in reduced costs and fewer diagnosed years of life than a no screening strategy in which all children suspected of FASD receive diagnostic testing. The model predicts that screening newborns with meconium testing results in a reduced cost of $89,186 per 100 individuals screened and 38 fewer diagnosed years of life by age 18, corresponding to an incremental cost-effectiveness ratio (ICER) of $2,359. Screening children with the NST resulted in a reduced cost of $183,895 per 100 individuals screened and 77 fewer diagnosed years of life by age 18, corresponding to an ICER of $2,390. Conclusion Findings suggest that screening is associated with less use of healthcare recourses but also fewer years of life with an FASD diagnosis over a no screening strategy. Since diagnosis can be key to children receiving timely and appropriate health and educational services, cost-savings must be weighed against the fewer years of life with a diagnosis associated with screening.
Identification of Newcastle disease virus (NDV) genotype VIIi in wild birds in Turkey
Authors: Turan Nuri , Ozsemir Cemal , Yilmaz Aysun , Cizmecigil Utku Y , Aydin Ozge , Bamac Ozge Erdogan , Gurel Aydin , Kutukcu Ahmet , Ozsemir Kubra , Tali Emre , Tali Besim , Yilmaz Semaha , Yaramanoglu Mehmetcan , Tekelioglu Kaan , Ozsoy Serhat , Richt Juergen , Iqbal Munir , Yilmaz Huseyin 
Published: August 2019

Abstract
Background: Newcastle disease viruses (NDVs) can spread across continents via migratory birds. Hence, we investigated the frequency of NDV in both nonmigratory and birds migrating on the South East European flyway, in Istanbul, Turkey. Birds were trapped using nets placed around the Kucukcekmece lake Avcilar, Istanbul, in spring seasons of 2016 and 2018. In total, 297 birds belonging to 42 different species were trapped, categorised according to species and sex, and oropharyngeal swabs were collected. Swabs from 115 mallards caught by hunters in Edirne and from 207 birds belonging to 31 species which had been treated in the Veterinary Faculty of Istanbul were also collected. Tissue samples were taken from dead wild birds brought by public to Veterinary Faculty of Istanbul. A total of 619 oropharyngeal swabs were pooled into 206 samples. RNA was extracted from the swabs and tissue samples. Real-time RT-PCR prob assay was used to detect NDV-RNA in samples.
Results: There was no amplification in real time RT-PCR in samples taken from wild birds caught by traps. However, amplification of NDV-F gene was observed in oropharyngeal swabs taken from 2 waterfowls, and in tissue samples taken from 2 little owls and 1 common kestrel. Sequencing and phylogenetic analyses of these 5 samples for NDV-F gene showed great similarity with NDV lineage VIIi viruses. One (waterfowl) of the five NDV-F gene sequences obtained in this study was slightly different than previously isolated Turkish NDVs and NDVs from Bulgaria and Georgia. Remaining four NDV-F gene sequences were similar to NDVs that were previously isolated in Turkey, Bulgaria and Georgia. Although the strains found in this study are closely related, there is a relatively small degree of molecular divergence within F gene of the Turkish NDVs and strains from Iran Pakistan, Israel and Belgium.
Conclusions: Our findings show that first time in Turkey, genotype VIIi of NDVs is predomiant in wild birds in the Eurasia region and some degree of molecular evolution when compared to the earlier NDV-VIIi isolates in Turkey. Also, NDV viruses prevailing in the migratory birds pose a serious risk to poultry in Turkey and other countries.
Second-line chemotherapy using taxane in patients with advanced gastric cancer who presented with severe peritoneal metastasis: A multicenter retrospective study
Authors: Arai Hiroyuki , Kawahira Masahiro , Yasui Hirofumi , Masuishi Toshiki , Muro Kei , Nakajima Takako Eguchi 
Published: August 2019

Abstract
Background

Individuals with advanced gastric cancer (AGC) who present with severe peritoneal metastasis (SPM) have poor prognosis, and the need to improve treatment for such condition and survival time is not met. Moreover, there are only few data about the second-line treatment for patients with such condition.

Methods

This retrospective study included patients receiving taxane-based second-line chemotherapy at three institutions in Japan between 2010 and 2016. Patients with AGC who present with SPM were included if they had massive ascites and/or inadequate oral intake requiring intravenous nutritional support. The efficacy and safety of the treatment were evaluated.

Results

In the present study, 43 (40%) of 108 patients had an Eastern Cooperative Oncology Group Performance Status score > 2, and the median serum albumin level of the patients was 3.3 g/mL. Ramucirumab was used in combination with paclitaxel in 21 patients. The median overall survival (OS) and progression-free survival (PFS) were 5.1 and 2.8 months, respectively. Inadequate oral intake was considered a negative prognostic factor of both OS and PFS in the multivariate analysis. Three treatment-related deaths were observed, which include those attributed to febrile neutropenia, gastrointestinal perforation, and pneumonitis. Common grade > 3 adverse events were neutropenia (35%), leukopenia (30%), anemia (24%), and anorexia (16%). We observed febrile neutropenia in 8% and gastrointestinal perforation in 4% of patients, and such conditions were primarily observed in patients with inadequate oral intake.

Conclusions

Taxane-based second-line chemotherapy was effective and safe for patients with AGC who present with SPM. Attention must be provided when treating patients with inadequate oral intake as they are likely to have short prognosis and serious toxicities.
Latent Dirichlet Allocation in Predicting Clinical Trial Failures
Authors: Geletta Simon , Follett Lendie , Laugerman Marcia R 
Published: August 2019

Abstract
Background : This study used natural language processing (NLP) and machine learning (ML) techniques to identify reliable patterns from within research narrative documents to distinguish studies that complete successfully, from the ones that terminate. Recent research findings have reported that at least ten percent of all studies that are funded by major research funding agencies terminate without yielding useful results. Since it is well-known that scientific studies that receive funding from major funding agencies are carefully planned, and rigorously vetted through the peer-review process, it was somewhat daunting to us that study-terminations are this prevalent. Moreover, our review of the literature about study terminations suggested that the reasons for study terminations are not well understood. We therefore aimed to address that knowledge gap, by seeking to identify the factors that contribute to study failures.
Method : We used data from the clinicialTrials.gov repository, from which we extracted both structured data (study characteristics), and unstructured data (the narrative description of the studies). We applied natural language processing techniques to the unstructured data to quantify the risk of termination by identifying distinctive topics that are more frequently associated with trials that are terminated and trials that are completed. We used the Latent Dirichlet Allocation (LDA) technique to derived 25 “topics” with corresponding sets of probabilities, which we then used to predict study-termination by utilizing random forest modeling. We fit two distinct models – one using only structured data as predictors and another model with both structured data and the 25 text topics derived from the unstructured data.
Results : In this paper, we demonstrate the interpretive and predictive value of LDA as it relates to predicting clinical trial failure. The results also demonstrate that the combined modeling approach yields robust predictive probabilities in terms of both sensitivity and specificity, relative to a model that utilizes the structured data alone.
Conclusions : Our study demonstrated that the use of topic modeling using LDA significantly raises the utility of unstructured data in better predicating the completion vs. termination of studies.
The olfactory secretome varies according to season in female sheep and goat
Authors: CANN Paul , CHABI Malika , DELSART Aliénor , DANVIC Chrystelle LE , SALIOU Jean-Michel , CHASLES Manon , KELLER Matthieu , MEILLOUR Patricia NAGNAN-LE 
Published: August 2019

Abstract
Background: Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulation of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results: In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O-GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O-GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion: Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their sensory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.