bluuebunny/crossref_metadata_2025_split huggingface dataset:
Floristic affinities of the lowland savannahs of Belize and southern Mexico
Authors: Canché-Estrada Idalia Arely , Ortiz-Díaz Juan Javier , Tun-Garrido Juan 
Published: March 2018

Environmental heterogeneity of Belize and southern Mexico savannahs as well as their geographical location suggest that these plant communities share floristic elements, making them conducive to a phytogeographical analysis. The aim of this study was to analyse the floristic affinities of nine savannahs of Belize and southern Mexico and to explain the similarities and differences amongst them.
A binary data matrix containing 915 species was built based on the authors’ own collections and on nine floristic lists already published. A second data matrix, consisting of 113 species representing trees, was also used since most literature on neotropical savannahs has focused on this life form. In addition, the ten most species-rich families as well as the characteristic species present in more than five savannahs were analysed. Floristic similarities were calculated using the Jaccard index. Dendrograms obtained in both types of analysis showed clusters with low similarity values, corresponding to geographic locations formed by the savannahs of Belize-Tabasco and the Yucatan Peninsula.
The floristic affinities of the savannahs may be explained in terms of heterogeneity in climate and physiography. The Yucatan Peninsula and Belize-Tabasco groups have differences in climate type and the amount of rainfall. In addition, the Yucatan Peninsula savannahs are established at the bottom of karstic valleys, while the Belize and Tabasco savannahs develop on extensive flatlands. The savannahs of Oaxaca have the same climate type and amount of rainfall as those of the Yucatan Peninsula but they are distributed along peaks and the slopes of shale hills. Fabaceae and Poaceae mainly dominated the local floras with 121 and 116 species each; remarkably, Melastomataceae was absent in the Yucatan Peninsula and Oaxaca. Nine species occurred in five to seven savannahs, confirming that they are widespread in both Belize and southern Mexico, and the Neotropics. Geographic location and floristic affinities of the nine savannahs support, to some extent, three different biogeographic provinces.
MTOR Suppresses Environmental Particle-Induced Inflammatory Response in Macrophages
Authors: Li Zhouyang , Wu Yinfang , Chen Hai-Pin , Zhu Chen , Dong Lingling , Wang Yong , Liu Huiwen , Xu Xuchen , Zhou Jiesen , Wu Yanping , Li Wen , Ying Songmin , Shen Huahao , Chen Zhi-Hua 
Published: March 2018

Abstract
Increasing toxicological and epidemiological studies have demonstrated that ambient particulate matter (PM) could cause adverse health effects including inflammation in the lung. Alveolar macrophages represent a major type of innate immune responses to foreign substances. However, the detailed mechanisms of inflammatory responses induced by PM exposure in macrophages are still unclear. We observed that coarse PM treatment rapidly activated mechanistic target of rapamycin (MTOR) in mouse alveolar macrophages in vivo, and in cultured mouse bone marrow–derived macrophages, mouse peritoneal macrophages, and RAW264.7 cells. Pharmacological inhibition or genetic knockdown of MTOR in bone marrow–derived macrophages leads to an amplified cytokine production upon PM exposure, and mice with specific knockdown of MTOR or ras homolog enriched in brain in myeloid cells exhibit significantly aggregated airway inflammation. Mechanistically, PM activated MTOR through modulation of ERK, AKT serine/threonine kinase 1, and tuberous sclerosis complex signals, whereas MTOR deficiency further enhanced the PM-induced necroptosis and activation of subsequent NF κ light-chain–enhancer of activated B cells (NFKB) signaling. Inhibition of necroptosis or NFKB pathways significantly ameliorated PM-induced inflammatory response in MTOR-deficient macrophages. The present study thus demonstrates that MTOR serves as an early adaptive signal that suppresses the PM-induced necroptosis, NFKB activation, and inflammatory response in lung macrophages, and suggests that activation of MTOR or inhibition of necroptosis in macrophages may represent novel therapeutic strategies for PM-related airway disorders.
Brugbouer tussen generasies: Koos Roets se samewerkingsnetwerk in die Afrikaanse filmbedryf
Authors: Senekal Burgert A. , Geldenhuys Cornelia 
Published: March 2018

Bridge builder between generations: Koos Roets’s cooperation network in the Afrikaans film industry. Koos Roets’s contribution to the Afrikaans film industry is widely recognised. Nevertheless, very little has been published specifically about his role in the Afrikaans film industry, although many studies exist about his collaborators such as Jans Rautenbach and Katinka Heyns. This article investigates Roets’s collaboration network by means of a network analysis, and identifies the persons with whom he collaborated the most, indicating his varied roles on different films. It is also indicated that he not only is and was an important role-player in his own right in this industry, but has also collaborated with many other important role-players in the Afrikaans film industry. He has contributed to Afrikaans films in collaboration with more than a 1000 persons throughout his career of nearly six decades. The directors, producers, sound operators, actors and crew with whom he has collaborated the most are highlighted, and the films on which they worked together are mentioned.
Malignancy Associated Microangiopathic Hemolytic Anemia and Thrombocytopenia
Authors: Abdulla Mansoor C , Alungal Jemshad , Nair Lekha K , Musambil Mohthash 
Published: March 2018

AbstractDisseminated malignancy can rarely present with microangiopathic hemolytic anemia and thrombocytopenia clinically similar to thrombotic thrombocytopenic purpura (TTP), but does not respond to plasma exchange. TTP carries a grave prognosis if plasma exchange is delayed. Evaluating patients presenting with microangiopathic hemolytic anemia and thrombocytopenia is challenging for clinicians. Thrombotic thrombocytopenic purpura (TTP) should be considered in such patients and emergency plasma exchange is to be initiated. But all the clinical features seen in TTP can be caused by a disseminated malignancy. The awareness of such a rare presentation of disseminated malignancy helps clinicians to avoid unnecessary delay in appropriate treatment and the complications due to plasma exchange. We report two patients who presented with microangiopathic hemolytic anemia and thrombocytopenia due to disseminated malignancy.
Peculiarities of Yolk Sac Tumor in Head and Neck: A Case Report and Literature Review
Authors: Devaraja K , Sikka Kapil , Singh Pankaj Kumar 
Published: March 2018

AbstractYolk sac tumor (YST) is the most common malignant germ cell tumor of head and neck region, constituting around 1% of all malignant germ cells. The rarity of the tumor has led to a relatively sparse collective description of clinical and prognostic factors of such a tumor affecting head and neck region. In this case report with review of the literature, we have highlighted certain peculiar features of YSTs affecting the head and neck region. They seem to commonly affect female children. These tumors seem to fare poorly in children of <1 year of age. Multimodality of treatment consisting of combination chemotherapy with the cisplatin-based regimen and surgery and/or radiotherapy helps in achieving long-term disease-free survival in those affected.
A Rare Nonhepatocytic Primary Liver Neoplasm with an Unusual Presentation: Ossifying Malignant Mixed Epithelial and Stromal Tumor
Authors: Venus Albina , Mehta Sangita Sharma , Natarajan Sumathi 
Published: March 2018

AbstractWe present a case of a rare liver neoplasm – Ossifyimg malignant mixed epithelial and stromal tumor. This entity has well-delineated morphological and immunohistochemical features, and so can be easily diagnosed, even with core biopsy tissue. Our patient was a middle-aged male, which is unheard of in the literature of this disease. He had a bad recurrence of the disease after surgical removal of the tumor, unlike the previously reported cases with the same diagnosis, where the patients lived for almost a decade after surgery without recurrence. This neoplasticdisease can thus take a destructive course, and a change in treatment methods such as neoadjuvant or adjuvant chemotherapy should be thought of, to make it more beneficial and effective.
Elevated p63 Expression as an Indicator for Poorer Prognosis in Squamous Cell Carcinomas of the Oral Cavity: An Immunohistochemical Study
Authors: Venkatesh Arvind , Wadhwan Vijay , Aggarwal Pooja , Reddy Vandana , Sharma Preeti , Gotur Suhasini Palakshappa , Saxena Chitrapriya 
Published: March 2018

Abstract
Background: Oral cancer remains one of the most debilitating and disfiguring of all malignancies. The survival rates for oral cancer vary, depending on several factors. Although p63 is an accepted prognostic marker in various other carcinomas, no consensus has been obtained till date regarding the applicability of p63 as a prognostic marker in head and neck squamous cell carcinomas (SCC). Aim and Objectives: The present study was conducted to determine the applicability of p63 as a prognostic marker in oral squamous cell carcinomas (OSCC) using incisional biopsies. Materials and Methods: Incisional biopsies of 27 candidates who were histopathologically diagnosed with SCC (8070/3) of the oral cavity (C06.9) (OSCC) between January 2013 and June 2014 were included in the trial. Sections were subjected to immunohistochemistry with p63 as the primary antibody. The percentage p63 expression was calculated and compared based on their Broders' and Anneroth's multifactorial grading systems with the overall survival status of the patients. Results and Observations: A statistically significant increase (P = 0.0203) was found between p63 expression and the histological grading of the tumor (from Grade I OSCC to Grade III OSCC). Similarly, a statistically significant correlation (P = 0.013) was obtained between mean Anneroth score (MAS) and the Broders' grading. Log-rank (Mantel-Cox) test showed statistical significance for the survival curves when the candidates were classified based on % p63 expression (P = 0.0049) and MAS (P = 0.0003). Conclusion: We have shown expression of p63 to correlate with survival in OSCCs, where high expression was seen in tumors with poorer survival after treatment. Furthermore, the usage and importance of Anneroth's multifactorial grading system over Broders' grading system in routine histopathological reporting for incisional biopsies of OSCCs is stressed.
Bowel Lymphoma in Children: Management and Outcome
Authors: Veerabhadra R , Kumar G Krishna , Bibekanand J , Kumar N Bikash , Kumaravel S , Bhawana B , Biswajit D 
Published: March 2018

Abstract
Background: Primary bowel lymphoma is an uncommon neoplasm in children and not well documented in literature with regard to its outcome and management. Materials and Methods: A case record review of children with bowel lymphoma was undertaken in a tertiary care institute, from 2010 to 2016 and the relevant data were recorded. Results: 21 children were managed with bowel lymphoma over a period of 7 years. Pain abdomen was the most common presenting symptom (19/21). Ileum was the site of involvement in most children (17/21). Localised disease was seen in 13/21 while 8 had diffuse involvement. Predominantly (13/21) children presented at an advanced stage (III/IV). Surgical intervention was needed in 14/21 while 7/21 were managed only with chemotherapy. Majority (15/21) had Burkitt's lymphoma on histology. 13 of 21 (61.9%) have completed chemotherapy and on regular follow up. Among 8 who died, 6 were directly related to disease progression despite aggressive management. Conclusion: Bowel lymphoma in children is distinctly different in the site of presentation from that of the adults. Advanced stage at presentation portends poor prognosis. Bowel lymphoma is to be considered in case of recurrent intussusception in children.
In situ high-temperature gas sensors: continuous monitoring of the combustion quality of different wood combustion systems and optimization of combustion process
Authors: Kohler Heinz , Ojha Binayak , Illyaskutty Navas , Hartmann Ingo , Thiel Christian , Eisinger Konrad , Dambacher Markus 
Published: March 2018

Abstract. The sensing characteristics and long-term stability of different
kinds of CO ∕ HC gas sensors (non-Nernstian mixed potential type) during
in situ operation in flue gas from different types of low-power
combustion systems (wood-log- and wood-chip-fuelled) were investigated. The
sensors showed representative but individual sensing behaviour with respect to
characteristically varying flue gas composition over the combustion process.
The long-term sensor signal stability evaluated by repeated exposure to
CO ∕ H2 ∕ N2 ∕ synthetic air mixtures showed no sensitivity loss
after operation in the flue gas. Particularly for one of the sensors
(Heraeus GmbH), this high signal stability was observed in a field
test experiment even during continuous operation in the flue gas of the
wood-chip firing system over 4 months. Furthermore, it was experimentally
shown that the signals of these CO ∕ HC sensing elements yield important
additional information about the wood combustion process. This was
demonstrated by the adaptation of an advanced combustion airstream control
algorithm on a wood-log-fed fireplace and by the development of a combustion
quality monitoring system for wood-chip-fed central heaters.
Band and Orchestra Teachers’ Primary Instrument Playing Inside and Outside the Classroom
Authors: Millican J. Si , Pellegrino Kristen 
Published: March 2018

Abstract
The purpose of this descriptive survey study was to investigate trends, characteristics, beliefs, and music-making practices of band and orchestra teachers. Respondents (N = 791) indicated that they taught band (n = 525) and/or orchestra (n = 381) at the elementary (n = 306), middle school (n = 493), and/or high school (n = 401) levels. These teachers reported that they (a) played their instruments more frequently for their least-advanced students than for their most-advanced students, (b) most frequently used modeling for their least-advanced students to demonstrate technique and model tone quality, and (c) most frequently used modeling for their most-advanced students to demonstrate musicality or musical style. Directors who played string instruments were more likely than their wind and percussion counterparts to report modeling for their most-advanced students. We also found that middle school directors claimed to model most frequently compared to elementary and high school directors. Respondents valued modeling most for being an effective teaching tool but also found that modeling promoted student engagement and motivation and was a relationship-building tool. Almost all of our respondents (94.9%) reported playing their primary instruments outside of the classroom, and the most frequent reasons were that it was part of their identity, it kept their performing skills sharp in order to model for students, and it contributed to personal satisfaction and well-being. Orchestra directors were more likely to play outside the classroom than band teachers, and orchestral string players were more likely to play outside the classroom than wind, percussion, piano, or guitar principals.
Multisequent Gentzen Deduction Systems For B<sub>2</sub> <sup>2</sup>-Valued First-Order Logic
Authors: Li Wei , Sui Yuefei 
Published: March 2018

For the four-element Boolean algebra B22, a multisequent Г|Δ|∑|∏ is a generalization of sequent Г→Δ in traditional B22 valued first-order logic. By defining the truth-values of quantified formulas, a Gentzen deduction system G22 for B22-valued first-order logic will be built and its soundness and completeness theorems will be proved.
Acquired Resistance to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancers: The Role of Next-Generation Sequencing on Endobronchial Ultrasound–Guided Transbronchial Needle Aspiration Samples
Authors: Guerini-Rocco Elena , Passaro Antonio , Casadio Chiara , De Luca Valeria Midolo , Guarize Juliana , de Marinis Filippo , Vacirca Davide , Barberis Massimo 
Published: March 2018

Context.—
Molecular testing is essential for the diagnostic workup of patients with advanced non–small cell lung cancers. Cytology specimens from minimally invasive procedures, such as endobronchial ultrasound–guided transbronchial needle aspiration, are often the only available samples for these patients. The implementation of molecular diagnostic testing, and in particular next-generation sequencing–based testing, on these cytologic specimens is currently an evolving field for lung cytopathology. The application of these molecular analyses on tyrosine kinase inhibitor–resistant non–small cell lung cancers raises unique technical, biologic, and clinical challenges.

Objective.—
To provide an overview of the implementation of next-generation sequencing analysis on endobronchial ultrasound–guided transbronchial needle aspiration samples to detect the molecular aberrations underneath the phenomenon of acquired resistance in patients with non–small cell lung cancers progressing while on the EGFR/ALK tyrosine kinase inhibitor treatment.

Data Sources.—
Peer-reviewed original articles, review articles, and published guidelines and expert opinion reports were reviewed, together with our single-center experience.

Conclusions.—
Next-generation sequencing analyses and the endobronchial ultrasound–guided transbronchial needle aspiration procedure may represent a valuable strategy to address the unique requirements of molecular testing on tyrosine kinase inhibitor–resistant non–small cell lung cancers.
The Role of Next-Generation Sequencing in the Cytologic Diagnosis of Pancreatic Lesions
Authors: de Biase Dario , Visani Michela , Acquaviva Giorgia , Fornelli Adele , Masetti Michele , Fabbri Carlo , Pession Annalisa , Tallini Giovanni 
Published: March 2018

Context.—Integration of the analysis of genetic markers with endoscopic ultrasound–guided fine-needle aspiration and cytologic evaluation has increased the accuracy of the preoperative diagnosis of pancreatic lesions. The application of high-throughput gene panel analysis using next-generation sequencing platforms is now offering a great opportunity for further improvements.Objective.—To review the application of next-generation sequencing to the preoperative diagnosis of pancreatic lesions.Data Sources.—For data acquisition, a PubMed search using the terms next-generation sequencing, pancreas, pancreatic lesions, pancreatic tumors, and EUS-FNA was performed covering the years 2000–2017.Conclusions.—KRAS remains the gene most widely studied for preoperative single-gene tests. Next-generation sequencing reliably allows analysis of multiple gene markers starting from limited amounts of DNA. The study of multigene panels has become a very attractive option for the management and preoperative risk stratification of patients with pancreatic cancer.
Perspective historique de la responsabilité sociale des entreprises (RSE)
Authors: JBARA Nejla 
Published: March 2018

La responsabilité sociale des entreprises est une notion très répandue sur le plan international, aussi bien dans les pays développés que dans les pays sous-développés. Le Maroc ne fait pas exception : il adhère bel et bien à cette pratique, constituant depuis quelques années un chantier dans lequel innovation sociale et économique sont en plein développement. En bref, les entreprises qui y pratiquent sont amenées à jouer un rôle qui dépasse le cadre de leur activité économique, en participant au bien public, en luttant contre la pauvreté, l’analphabétisme, etc., ainsi qu’en promouvant le développement durable, la gouvernance, l’éthique et l’instauration d’une philosophie conforme aux droits de l’homme. Depuis la fin de la Seconde Guerre mondiale, on a pu distinguer trois vagues successives de conception de la RSE : dans les années 1950, la conception éthique aux États-Unis ; dans les années 1970-1990, la conception utilitariste aux États-Unis ; depuis 1990, la conception fondée sur la soutenabilité dans les pays européens occidentaux qui est loin d’être arrivée à maturité encore de nos jours.Dans notre article, nous essaierons de définir ces trois conceptions de la RSE en nous attardant aux différents termes qui ont vu le jour en association avec cette notion : éthique, gouvernance, développement durable, management responsable, etc. Nous exposerons en même temps le cas du Maroc, en tant que situation prometteuse d’intégration de la RSE dans les pays en développement.L’analyse de ces trois conceptions se fera dans une perspective historique, par la présentation des lieux et des dates d’apparition et de développement de cette notion, y compris de son développement historique au Maroc.
Time Attributable to Obesity in Surgery: A Multi‐specialty Report on Day‐of‐Surgery Resource Utilization from 189,264 Cases
Authors: Burneikis Dominykas , Morris‐Stiff Gareth , Chalikonda Sricharan 
Published: March 2018

AbstractBackgroundObesity presents a unique challenge in caring for surgical patients and has been shown to adversely affect outcomes for several operative procedures. However, quantitative data on surgical resource utilization attributable to obesity are scarce. The aim of this study was to quantify day‐of‐surgery resource utilization by degree of obesity.MethodsPatients undergoing one of 14 common surgical procedures at our multicenter institution between 2008 and 2017 were identified from our operating room management databank. Multiple‐variable regression analysis (MVRA) was performed to quantify the independent effect of body mass index (BMI) category on day‐of‐surgery resource utilization variables including procedure time, non‐operative OR time, PACU time, number of unique staff and number of supplies used. Trends in mean BMI were examined for each procedure studied.ResultsMVRA of the 189,264 cases in the database revealed consistently significant (p < 0.05) stepwise increase in procedure time by BMI category for all procedures studied. Non‐operative OR time was also significantly prolonged, though to a lesser degree. There was no significant impact on number of unique staff, supplies utilized or PACU time by BMI category. Procedures most impacted by BMI category in terms of resource utilization were ventral hernia repair, laminectomy and hysterectomy.ConclusionOur study quantified day‐of‐surgery resource utilization for 14 major surgical procedures by BMI category. The need for additional resources to accommodate patients in higher BMI groups was consistent across all procedures studied and was primarily reflected by lengthened operative times.