bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sixty Years of Widespread Warming in the Southern Middle and High Latitudes (1957–2016)
Authors: Jones Megan E. , Bromwich David H. , Nicolas Julien P. , Carrasco Jorge , Plavcová Eva , Zou Xun , Wang Sheng-Hung 
Published: July 2019

AbstractTemperature trends across Antarctica over the last few decades reveal strong and statistically significant warming in West Antarctica and the Antarctic Peninsula (AP) contrasting with no significant change overall in East Antarctica. However, recent studies have documented cooling in the AP since the late 1990s. This study aims to place temperature changes in the AP and West Antarctica into a larger spatial and temporal perspective by analyzing monthly station-based surface temperature observations since 1957 across the extratropical Southern Hemisphere, along with sea surface temperature (SST) data and mean sea level pressure reanalysis data. The results confirm statistically significant cooling in station observations and SST trends throughout the AP region since 1999. However, the full 60-yr period shows statistically significant, widespread warming across most of the Southern Hemisphere middle and high latitudes. Positive SST trends broadly reflect these warming trends, especially in the midlatitudes. After confirming the importance of the southern annular mode (SAM) on southern high-latitude climate variability, the influence is removed from the station temperature records, revealing statistically significant background warming across all of the extratropical Southern Hemisphere. Antarctic temperature trends in a suite of climate models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) are then investigated. Consistent with previous work the CMIP5 models warm Antarctica at the background temperature rate that is 2 times faster than that observed. However, removing the SAM influence from both CMIP5 and observed temperatures results in Antarctic trends that differ only modestly, perhaps due to natural multidecadal variability remaining in the observations.
On the Westward Turning of Hurricane Sandy (2012): Effect of Atmospheric Intraseasonal Oscillations
Authors: Ding Liudan , Li Tim , Xiang Baoqiang , Peng Melinda 
Published: July 2019

Abstract
Hurricane Sandy (2012) experienced an unusual westward turning and made landfall in New Jersey after its northward movement over the Atlantic Ocean. The landfall caused severe casualties and great economic losses. The westward turning took place in the midlatitude Atlantic where the climatological mean wind is eastward. The cause of this unusual westward track is investigated through both observational analysis and model simulations. The observational analysis indicates that the hurricane steering flow was primarily controlled by atmospheric intraseasonal oscillation (ISO), which was characterized by a pair of anticyclonic and cyclonic circulation systems. The anticyclone to the north was part of a global wave train forced by convection over the tropical Indian Ocean through Rossby wave energy dispersion, and the cyclone to the south originated from the tropical Atlantic through northward propagation. Hindcast experiments using a global coupled model show that the model is able to predict the observed circulation pattern as well as the westward steering flow 6 days prior to Sandy’s landfall. Sensitivity experiments with different initial dates confirm the important role of the ISO in establishing the westward steering flow in the midlatitude Atlantic. Thus the successful numerical model experiments suggest a potential for extended-range dynamical tropical cyclone track predictions.
Real-World Outcomes of an Automated Physician Support System for Genome-Driven Oncology
Authors: Tao Jessica J. , Eubank Michael H. , Schram Alison M. , Cangemi Nicholas , Pamer Erika , Rosen Ezra Y. , Schultz Nikolaus , Chakravarty Debyani , Philip John , Hechtman Jaclyn F. , Harding James J. , Smyth Lillian M. , Jhaveri Komal L. , Drilon Alexander , Ladanyi Marc , Solit David B. , Zehir Ahmet , Berger Michael F. , Stetson Peter D. , Gardos Stuart M. , Hyman David M. 
Published: July 2019

PURPOSE Matching patients to investigational therapies requires new tools to support physician decision making. We designed and implemented Precision Insight Support Engine (PRECISE), an automated, just-in-time, clinical-grade informatics platform to identify and dynamically track patients on the basis of molecular and clinical criteria. Real-world use of this tool was analyzed to determine whether PRECISE facilitated enrollment to early-phase, genome-driven trials. MATERIALS AND METHODS We analyzed patients who were enrolled in genome-driven, early-phase trials using PRECISE at Memorial Sloan Kettering Cancer Center between April 2014 and January 2018. Primary end point was the proportion of enrolled patients who were successfully identified using PRECISE before enrollment. Secondary end points included time from sequencing and PRECISE identification to enrollment. Reasons for a failure to identify genomically matched patients were also explored. RESULTS Data were analyzed from 41 therapeutic trials led by 19 principal investigators. In total, 755 patients were accrued to these studies during the period that PRECISE was used. PRECISE successfully identified 327 patients (43%) before enrollment. Patients were diagnosed with 29 tumor types and harbored alterations in 43 oncogenes, most commonly ERBB2 (21.3%), PIK3CA (14.1%), and BRAF (8.7%). Median time from sequencing to enrollment was 163 days (interquartile range, 66 to 357 days), and from PRECISE identification to enrollment 87 days (interquartile range, 37 to 180 days). Common reasons for failing to identify patients before enrollment included accrual on the basis of molecular alterations that did not match pre-established PRECISE genomic eligibility (140 [33%] of 428) and external sequencing not available for parsing (127 [30%] of 428). CONCLUSION PRECISE identified 43% of all patients accrued to a diverse cohort of early-phase, genome-matched studies. Purpose-built informatics platforms represent a novel and potentially effective method for matching patients to molecularly selected studies.
Islam, Puritanism, and Secular Time
Authors: Trigg Christopher 
Published: July 2019

Abstract
This article reconsiders the legacy of American Puritanism in the context of the current controversy around “radical Islam.” The rise of Salafi jihadism has emboldened those who maintain that Islam is incompatible with Western secularity. Liberal responses to this claim frequently appeal to the United States’ allegedly Puritan past, suggesting that the United States is particularly well placed to deal with both radical Islamism and anti-Islamic prejudice because of the ecumenical pluralism that emerged from the colonial crucible of competing denominations. I interrogate this claim by reading liberal and conservative statements about Muslims in the contemporary United States alongside the writings of Roger Williams, whom many consider to be the father of American pluralism. I argue that the modern rhetoric of religious diversity mirrors the eschatological structure of Williams’s tenet of toleration, wherein Muslims are offered only temporary acceptance. In each case, the pluralism of the present is set off against an anticipated cultural homogeneity.
Father, Where Art Thou? Catholic Priests and Mexico's 1929Relación de Sacerdotes
Authors: Butler Matthew , Powell Kevin D. 
Published: July 2019

AbstractThis article studies an ecclesiastical census, the Relación de sacerdotes, that was compiled by the Secretariat of the Interior during Mexico's Cristero War in 1929. We propose that this statistical device ultimately helped the Catholic Church and the Portes Gil government to plot a way out of the religious crisis. It did so by providing a mutually acceptable means for priests to register with the postrevolutionary state and by providing a discursive mechanism for the Catholic clergy to present itself to the regime as a national, less Rome-oriented body. The Relación can therefore give historians insights into the contingent and bureaucratic ways that revolutionary and ecclesiastical elites renegotiated the contours of Mexico's secular order. The second half of the article contains an analysis of the Relación. There we argue that the Relación offers a kind of prosopographical and political snapshot of the Mexican clergy during the Cristero Rebellion.
Allegory of the Global Anglophone: Interconnectedness and Sublimity inCloud Atlas
Authors: Tsang Philip 
Published: July 2019

AbstractThe article situates David Mitchell's imagination of planetary interconnectedness in the historical development of global English. It argues that Cloud Atlas projects a denationalized, centrifugal vision of the world, only to entrench it in a cohesive, centripetal anglophone network through fictionalized scenes of reading. The novel assigns the English text a privileged position in fostering global connections and renders its cultural other unrepresentable in order to maintain a coherent representational system over a heterolingual world. Mitchell's imagination of a textually embedded connectivity descends from an older ideology of literature-as-mediation that originated from colonial literary education.
Proust's Genies: In Search of Lost Time and Population Biology
Authors: Walser Hannah 
Published: July 2019

Abstract
Whether identified as “genies,” “little men,” or simply “les moi,” a vast horde of personified mental faculties populates In Search of Lost Time, responsible for behaviors too instantaneous or too ingrained to come under conscious control. Representing automatic neural subroutines as self-interested beings allows Proust to apply the principles of biological selection to these psychological entities, imagining the mind as an ecosystem in which great personal upheavals—for instance, Marcel's loss of Albertine—figure as extinction events that wipe out large populations of narrowly specialized, slow-to-adapt “genies.” Since genies are optimized for highly specific micro-environments, the same “species” of genie may form in any two individuals who share such a micro-environment, with this indifference to the boundaries of the person making it possible for a shared genie-type to define an ad hoc social category: homosexuals, snobs, members of the Guermantes set. In this essay, I unpack Search's model of the mind as a population of simple homunculi and explore its effect on Proust's understanding of interpersonal collectives, from intellectual coteries to social classes. The construct of the genie, I suggest, not only allows Proust to suture together sub-individual and supra-individual scales of analysis but also enables a model of change—both psychological and historical—that is neither simply agentic nor simply deterministic. Rather, the shifting demographics of mental homunculi constitute a quantitative, probabilistic, and nonsychronous form of change, creating new adaptive niches while permitting the partial survival of prior forms of life.
Working the Kodak Zone
Authors: De Leon Adrian 
Published: July 2019

AbstractThis article traces a labor history of colonial photography and the visual production of race in the Philippine Cordilleras, as well as its diasporic performances abroad. It argues that the ethnological visuality of Spanish and American imperialisms in the mountains of Northern Luzon, which produced discourses of race and indigeneity for the purposes of colonial occupation and imperial politics, amounted to various labor relations between Cordillerans in front of the camera, Americans behind and around the camera, and global audiences in European and North American fair midways. What became known variously as the “industrious savage” or the “dog-eating Igorrote” at the turn of the twentieth century crystallized in part out of workers’ assertions to fair wages, good working conditions, and collective dignity. This essay seeks to provide new labor history frameworks through critical readings of photographs, their subjects, and their larger economies of production and circulation.
Imagining Racial Equality
Authors: Quirke Carol 
Published: July 2019

Abstract
Local 65 United Warehouse Workers Union (1933–1987), which became District 65 United Auto Workers, promoted photography with a camera club, and a member-edited newspaper New Voices, featuring photographs taken by members. This left-led, New York City distributive industry union began in 1933 on the Lower East Side, and it became the city’s second largest local. The union utilized photography to normalize the role of African American members within the union and to advance a civil rights and anti-racism agenda. This article includes photographs taken by member-photographers, and photo-reproductions of New Voices. New Voices’ photographs included African Americans in the everyday life of the union, challenged race-based labor segmentation, supported community struggles, and defied racial norms in midcentury America.
Dostoevsky's Timely Castration
Authors: Wilson Jennifer 
Published: July 2019

Abstract
This article is a profile of “the skoptsy,” a Christian sect that emerged in tsarist Russia whose followers, in an effort to divest themselves from the organs of sin, practiced castration as a form of religious piety. The skoptsy believed that before the fall of Adam and Eve, men and women did not have sexual organs; that its—they did not conceive of the original man and woman as being differentiated by their genitalia. The skoptsy were also millenarians, and as such they imagined the world would be transformed following an apocalyptic reckoning. In exploring how the temporal register of the skoptsy was depicted in the novels of Dostoevsky, the author proposes that the apocalyptic religious and political movements that were developing across imperial Russia can deepen contemporary discussions about queer temporality, in that they offer a counterpoint to arguments that the future is the realm of the normative reproducing subject.
99mTc-Hydroxydiphosphonate quantification of extracellular matrix mineralization in 3D human mesenchymal stem cell cultures
Authors: Grossner Tobias L. , Haberkorn Uwe , Gotterbarm Tobias 
Published: July 2019

ObjectivesBone tissue engineering is one of the fastest growing branches in modern bioscience. New methods are being developed to achieve higher grades of mineral deposition by osteogenically inducted mesenchymal stem cells. In addition to well established monolayer cell culture models, 3D cell cultures for stem cell-based osteogenic differentiation have become increasingly attractive to promote in vivo bone formation. One of the main problems of scaffold-based osteogenic cell cultures is the difficulty in quantifying the amount of newly produced extracellular mineral deposition, as a marker for new bone formation, without destroying the scaffold. In recent studies, we were able to show that99mTc-methylene diphosphonate (99mTc-MDP), a gamma radiation-emitting radionuclide, can successfully be applied as a reliable quantitative marker for mineral deposition as this tracer binds with high affinity to newly produced hydroxyapatite (HA).MethodsWithin the present study, we evaluated whether this promising new method, using99mTc-hydroxydiphosphonate (99mTc-HDP), can be used to quantify the amount of newly formed extracellular HA in a 3D cell culture model. Highly porous collagen type II scaffolds were seeded with 1 × 106 human mesenchymal stem cells (hMSCs; n = 6) and cultured for 21 days in osteogenic media (group A – osteogenic (OSM) group) and in parallel in standard media (group B – negative control (CNTRL) group). After incubation with99mTc-HDP, the tracer uptake, reflected by the amount of emitted gamma counts, was measured.ResultsWe saw a higher uptake (up to 15-fold) of the tracer in the OSM group A compared with the CNTRL group B. Statistical analysis of the results (Student`s t-test) revealed a significantly higher amount of emitted gamma counts in the OSM group (p = 0.048). Qualitative and semi-quantitative analysis by Alizarin Red staining confirmed the presence of extracellular HA deposition in the OSM group.ConclusionOur data indicate that99mTc-HDP labelling is a promising tool to track and quantify non-destructive local HA deposition in 3D stem cell cultures. Cite this article: T. L. Grossner, U. Haberkorn, T. Gotterbarm.99mTc-Hydroxydiphosphonate quantification of extracellular matrix mineralization in 3D human mesenchymal stem cell cultures. Bone Joint Res 2019;8:333–341. doi: 10.1302/2046-3758.87.BJR-2017-0248.R1.
Overweight, hypertension and microalbuminuria in urban and rural Bangladeshi schoolchildren
Authors: Islam Mohammad Majharul Islam , Benzamin Mohammad , Roy Ranjit Ranjan , Mamun Abdullah Al , Ahmed Muhammad Tanvir , Islam Mohammad Tariqul , Ashraf Rezwana , Karim Rezaul , Hossen Kamal , Biswas Susmita , Khatun Sufia 
Published: July 2019

Background The prevalence of childhood overweight and obesity has increased over the last two decades due to high caloric intake and decreased physical activity. The dramatic increase in the prevalence of overweight children occurred in conjunction with increasing prevalence of hypertension. Microalbuminuria is an early sign of damage to the kidney and cardiovascular system. Hypertensive, overweight children have an increased chance of microalbuminuria.
Objectives To assess the prevalence of overweight, hypertension, and microalbuminuria in urban and rural school going children and contributing risk factors and associations.
Methods This cross-sectional study was done in schoolchildren aged 6 to 16 years, from urban and rural areas, in Bangladesh, from September 2015 untill August 2016. Subjects’ weights, heights, and blood pressures (BP) were measured. Overweight and hypertension (HTN) statuses were determined with age-appropriate standardized charts. Subjects were divided into overweight and normoweight groups to evaluate risk factors for overweight such as family history (F/H) of obesity, F/H of HTN, daily physical outdoor activities, and monthly family income by comparative analysis. All overweight children were divided into hypertensive and normotensive groups in order to compare their fasting lipid profiles, urine microalbumin, serum creatinine, and random blood sugar.
Results A total of 976 schoolchildren from urban (471, 48.3%) and rural (505, 51.7%) areas were included. Overweight was observed in 22.3% of the urban group and in 8.1% of the rural group (P<0.001). Hypertension was observed in 24.7% of overweight children and in 2.5% of normal weight children (P<0.001). Contributing risk factors for overweight were less physical outdoor activities, F/H of obesity, F/H of HTN, and higher family income (P<0.001). Microalbuminuria and random blood sugar were significantly increased in the overweight with hypertension group compared to the normotensive group (P <0.005).
Conclusion Overweight is a health problem, noted especially in urban areas. Hypertension is also significantly increased in overweight children. Factors like F/H of hypertension, obesity, sedentary lifestyle, and higher socioeconomic status are significantly associated with overweight. Microalbuminuria and increased random blood sugar are also significantly higher observed in hypertensive overweight children compared to normotensive overweight children.
Risk factors for delayed speech in children aged 1-2 years
Authors: Tan Sabrina , Mangunatmadja Irawan , Wiguna Tjhin 
Published: July 2019

Background Speech delay is one of the most common developmental delays in children. To minimize the negative outcomes of speech delay, risk factors should be explored to help in early patient diagnosis.
Objectives To assess for associations between delayed speech in children aged 1 to 2 years and possible risk factors including gender, gestational age, birth weight, asphyxia during birth, head circumference, anterior fontanelle closure, gross motor development, duration of breastfeeding, caregiver identity, number of siblings, exposure to gadgets and television, and social interaction.
Methods Parents of children aged 1 to 2 years who were treated at Dr. Cipto Mangunkusumo Hospital, and Klinik Anakku, Pondok Pinang in Jakarta from January 2018 to March 2018 were interviewed. Data were processed with SPSS Statistics for Mac and analyzed by Chi-square test and logistic regression method.
Results Of 126 subjects, 63 children had speech delay and 63 children had normal speech development. Multivariate analysis revealed that the significant risk factors for delayed speech were delayed gross motor development (OR 9.607; 95%CI 3.403 to 27.122; P<0.001), exclusive breastfeeding for less than 6 months (OR 3.278; 95%CI 1.244 to 8.637; P=0.016), and exposure to gadgets and television for more than 2 hours daily (OR 8.286; 95%CI 2.555 to 26.871; P<0.001).
Conclusion Delayed gross motor development, exclusive breastfeeding for less than 6 months, media exposure for more than 2 hours daily, and poor social interaction are risk factors for delayed speech development in children.
Esophageal Actinomycosis Presenting as an Obstructive Esophageal Mass
Authors: Alshati Ali , Appleton Leslie , Maddux Jacob T. , Almohammedawi Mays , Dangerfield Benjamin 
Published: July 2019

ABSTRACT
Esophageal actinomycosis is a rare type of esophageal infection, with only approximately 24 cases previously reported in the United States. Most of these cases were described as erosions or ulcers when examined endoscopically. We present a 47-year-old woman who presented with dysphagia. Endoscopy showed a lower esophageal fungating mass, mimicking a malignant mass. Although there was a high suspicion of esophageal carcinoma, biopsy results showed esophageal actinomyces infection.
Pengklasteran Kabupaten/Kota di Jawa Tengah berdasarkan Tenaga Kesehatan dengan Menggunakan Metode Ward dan K-Means
Authors: Lestari Sri Puji , Supandi Epha Diana , Rahayu Pipit Pratiwi 
Published: July 2019

Analisis klaster merupakan suatu metode yang digunakan untuk mengelompokkan objek (kasus) ke dalam klaster (kelompok) yang relatif sama. Tujuan penelitian ini untuk mengklasterkan Kabupaten/Kota di Provinsi Jawa Tengah berdasarkan tenaga kesehatan tahun 2015 seperti tenaga medis, tenaga keperawatan, tenaga kebidanan, tenaga kefarmasian dan tenaga kesehatan lainnya dengan menggunakan metode Ward dan K-Means. Hasil penelitian menunjukkan ada tiga klaster terbentuk dimana metode Ward menghasilkan nilai rasio simpangan baku sebesar 0,3019% lebih besar jika dibandingkan dengan nilai rasio simpangan baku pada metode K-Means yaitu 0,2974%. Pada kasus ini, metode K-Means merupakan metode yang lebih baik dibandingkan metode Ward.
[Cluster analysis is a method used to group objects (cases) into clusters (groups) that are relatively the same. The purpose of this study is to classify districts/cities in Central Java Province based on health worker in 2015 such as medical personnel, nursing staff, midwifery staff, pharmacy personnel and health workers using the Ward and K-Means methods. The results show that there are three clusters formed where the Ward method produce a standard deviation ratio of 0.3019% greater than the standard deviation ratio in the K-Means method, which is 0.2974%. In this case, the K-Means method is a better method than the Ward method.]