bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of contrast water therapy on blood lactate concentration after high-intensity interval training in elite futsal players
Authors: Pelana Ramdan , Maulana Arman , Winata Bagus , Widiastuti Widiastuti , Sukur Abdul , Kuswahyudi Kuswahyudi , Juriana Juriana , Hermawan Rahmat 
Published: September 2019

IntroductionIn the process of improving an athlete’s performance, the recovery methods must be optimized. Recovery is required to maximize training and competition performance; fatigue should be minimized by recovering as fast as possible. This study aimed to assess effects of contrast water therapy on blood lactate concentration after high-intensity interval training (HIIT) in elite futsal players.MethodsA total of 30 male futsal athletes volunteered to be subjects in this study. The test session consisted of repeated sprints at the distance of 25 m (3 series of two 1-min repetitions at 90% of maximum heart rate). After HIIT, the participants were randomized into 2 groups; 15 received contrast water therapy (CWT), and 15 were given slow jogging recovery (SJR). The recovery for the CWT group consisted of periodic immersions in cold water (18°C) for 1 min and then in hot water (37°C) for 2 min, with accumulating 15 min in the water. The recovery for the SJR group included 8 min of slow jogging (6.8 km · h−1) around a field.ResultsAfter 30-min recovery, lactate concentration was significantly greater (<i>p</i> = 0.001) in the SJR group (7.67 mmol/l) than in the CWT group (6.82 mmol/l) and remained significantly different 60 min after recovery (<i>p</i> = 0.0001; 6.80 mmol/l and 5.01 mmol/l, respectively).ConclusionsWe demonstrated that CWT after HIIT had an effect on the recovery of elite futsal players by decreasing the lactate concentration and rapid recovery of heart rate.
Defining a prognostic criterion of orthopaedic complications development in patients with an injury of anterior cruciate ligament of knee joint
Authors: Rusanov Andrey , Roy Irina , Rusanova Olga 
Published: September 2019

IntroductionPrognostic indices of orthopaedic implications development were investigated among patients with anterior cruciate ligament (ACL) injuries on the basis of stabilography research during the functional period of rehabilitation.MethodsThe study included 52 randomly selected individuals with a complete ACL tear qualified for surgical reconstruction. The patients’ age was 18–59 (average: 37.8 ± 2.0) years. All participants underwent rehabilitation treatment in the Institute of Traumatology and Orthopaedics, National Academy of Medical Sciences of Ukraine, and had surgeries in the Institute’s clinics. The crural part of the graft was fixed with the assistance of either the RigidFix system or the Cross-Pin system, and the Biointrafix or Biosure Sync system was applied for the tibial part.Results and conclusionsOn the basis of the performed analysis of indices that characterize the functional condition of the injured limb of patients with an injury of ACL of knee joint at the functional stage of rehabilitation treatment, it is possible to identify a high and medium level of loading asymmetry in the lower extremities, decrease of electrobiological activity and muscle resistance ability during bending, stretching, adduction, and abduction, as the main prognostic criterion of orthopaedic complications development.
General practitioner databases in Australia
Authors: Saltman Deborah C , Mant Andrea 
Published: September 2019

ObjectiveGeneral practitioner‐based research has been hampered by the poorly defined database and the cost of continuous updating of lists of practitioners. Little is known about the general practitioner workforce. Fresh awareness by health planners of the serious maldistribution of general practitioners has heightened the need for workforce planning. Integral to this is the availability of an accurate listing of general practitioners.Data sourcesA CD‐ROM Medline review of all surveys involving general practitioners which were conducted in Australia in the period 1983‐1990 was performed. All general practitioner listings still existing at the end of the decade were identified.Study selectionNine listings considered for use as general practitioner databases.Data extractionEach listing was assessed in six ways — quality of information provided, availability for research purposes, cost, potential to provide the correct postal address, ability to identify general practitioners in active practice and comparative advantage over other lists.Data synthesisEach listing has limitations and advantages, with individual peculiarities and variable information relating to identifying characteristics of general practitioners. None was specifically created for research or workforce planning purposes. The Medical Provider File (formerly called the Central Register of Medical Practitioners) was the most used list.ConclusionsWe propose a framework for the ideal database and avenues for its development.
Sex steroid hormones and breast cancer: is there a link with oral contraceptives and hormone replacement therapy?
Authors: Khoo Soo Keat , Chick Pamela 
Published: September 2019

ObjectiveTo determine whether use of sex steroid hormones for contraception and hormone replacement therapy alters the risk of breast cancer, and whether the risk varies with their composition, duration of use, the period of a woman's life when the hormones are Used, and after successful treatment for breast cancer.Data sourcesThe results of important epidemiological reports, readily available from the English literature and published since 1981, were evaluated, using reports of basic scientific work as a background to the problem.Study selectionAn attempt was made to obtain most of the relevant reports. Twenty case‐control and seven cohort studies were available on the oral contraceptive pill (OCP) and eleven case‐control and five cohort studies on hormone replacement therapy (HRT).Data extractionThe relative risk estimates for breast cancer (and their 95% confidence intervals) determined by each report were tabulated according to the specific conditions of analysis, for example users under age 25, duration of use. Results by meta‐analysis from previous studies were also used to determine risk. A significant positive association was present when the risk estimate exceeded 1.0 and the 95% confidence interval did not cross 1.0.Data synthesisAmong OCP users, the vast majority of reports showed no significant risk of breast cancer — overall, longest duration of use, and use before first full‐term pregnancy. However, a positive association between breast cancer and users under age 25 was found in three of eight reports. Similarly, the majority of reports showed no significant risk of breast cancer among HRT users, overall as well as in relation to duration of use and interval since first use. There was no increased risk with additional progestogen; it may be protective. An improved prognosis was found in users who developed breast cancer. On the limited data, use of hormones for postmenopausal symptoms did not appear to be harmful to women who had been successfully treated for breast cancer.ConclusionsThe review revealed good evidence that use of sex steroid hormones had no significant effect on the risk of breast cancer, whether given for contraception or hormone replacement. There was some concern about increased risk with prolonged use of the OCP, especially in younger women. At present, use of these hormones is a matter of informed choice, with individual considerations of the risk‐benefit ratio.
La valutazione medico-legale delle ipoacusie in ambito assistenziale (invalidità civile e sordità civile) e previdenziale INPS
Authors: Sammicheli Michele , Scaglione Marcella 
Published: September 2019

The authors address the issue of hearing loss assessment for civil incapacity and INPS social security disability benefits.The purpose of this work is to compile an easy-to-use handbook for the public and for doctors unfamiliar with legal medicine who need to address the complex issue of performing a medical-legal assessment of hearing loss for INPS social security disability and civil incapacity.General practitioners often incorrectly fill out INPS online application forms to obtain subsidies from Local Health Authorities (ASL / ASP) for the purchase of hearing aids for entitled citizens recognised as legally disabled due to loss of hearing.Frequently, instead of «civil incapacity», doctors select the term «legal deafness», introduced in 2006 as the legislative definition for deaf-mute individuals, i.e. persons with congenital deafness or hearing impairments acquired during childhood that have affected the normal learning of speech.
Cellular accumulation and cytotoxic effects of zinc oxide nanoparticles in microalga Haematococcus pluvialis
Authors: Djearamane Sinouvassane , Lim Yang Mooi , Wong Ling Shing , Lee Poh Foong 
Published: September 2019

Background
Zinc oxide nanoparticles (ZnO NPs) are widely used in household and cosmetic products which imply an increased releasing of these particles into the environment, especially aquatic ecosystems, resulting in the need of assessing the potential toxic effects of ZnO NPS on the aquatic organisms, particularly on microalgae which form the base for food chain of aquatic biota. The present study has investigated the dose- and time-dependent cellular accumulation and the corresponding cytotoxic effects of increasing concentrations of ZnO NPs from 10–200 μg/mL on microalga Haematococcus pluvialis at an interval of 24 h for 96 h.

Methods
The scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) was used to qualitatively detect the cellular accumulation of ZnO NPs in algal cells, while inductively coupled plasma optical emission spectrometry (ICP OES) was performed to quantify the cell associated-zinc in algal cells. The percentage of cell death, reduction in algal biomass, and loss in photosynthetic pigments were measured to investigate the cytotoxic effects of ZnO NPs on H. pluvialis. Extracellular and intracellular changes in algal cells resulted from the treatment of ZnO NPs were demonstrated through optical, scanning, and transmission electron microscopic studies.

Results
SEM-EDX spectrum evidenced the accumulation of ZnO NPs in algal biomass and ICP OES results reported a significant (p < 0.05) dose- and time-dependent accumulation of zinc in algal cells from 24 h for all the tested concentrations of ZnO NPs (10–200 μg/mL). Further, the study showed a significant (p < 0.05) dose- and time-dependent growth inhibition of H. pluvialis from 72 h at 10–200 μg/mL of ZnO NPs. The morphological examinations revealed substantial surface and intracellular damages in algal cells due to the treatment of ZnO NPs.

Discussion
The present study reported the significant cellular accumulation of ZnO NPs in algal cells and the corresponding cytotoxic effects of ZnO NPs on H. pluvialis through the considerable reduction in algal cell viability, biomass, and photosynthetic pigments together with surface and intracellular damages.
Agent-Based Model of Combined Community- and Jail-Based Take-Home Naloxone Distribution
Authors: Tatara Eric , Ozik Jonathan , Pollack Harold A. , Schneider John A. , Friedman Samuel R. , Harawa Nina T. , Boodram Basmattee , Salisbury-Afshar Elizabeth , Hotton Anna , Ouellet Larry , Mackesy-Amiti Mary Ellen , Collier Nicholson , Macal Charles M. 
Published: December 2024

ImportanceOpioid-related overdose accounts for almost 80 000 deaths annually across the US. People who use drugs leaving jails are at particularly high risk for opioid-related overdose and may benefit from take-home naloxone (THN) distribution.ObjectiveTo estimate the population impact of THN distribution at jail release to reverse opioid-related overdose among people with opioid use disorders.Design, Setting, and ParticipantsThis study developed the agent-based Justice-Community Circulation Model (JCCM) to model a synthetic population of individuals with and without a history of opioid use. Epidemiological data from 2014 to 2020 for Cook County, Illinois, were used to identify parameters pertinent to the synthetic population. Twenty-seven experimental scenarios were examined to capture diverse strategies of THN distribution and use. Sensitivity analysis was performed to identify critical mediating and moderating variables associated with population impact and a proxy metric for cost-effectiveness (ie, the direct costs of THN kits distributed per death averted). Data were analyzed between February 2022 and March 2024.InterventionModeled interventions included 3 THN distribution channels: community facilities and practitioners; jail, at release; and social network or peers of persons released from jail. Main Outcomes and MeasuresThe primary outcome was the percentage of opioid-related overdose deaths averted with THN in the modeled population relative to a baseline scenario with no intervention.ResultsTake-home naloxone distribution at jail release had the highest median (IQR) percentage of averted deaths at 11.70% (6.57%-15.75%). The probability of bystander presence at an opioid overdose showed the greatest proportional contribution (27.15%) to the variance in deaths averted in persons released from jail. The estimated costs of distributed THN kits were less than $15 000 per averted death in all 27 scenarios.Conclusions and RelevanceThis study found that THN distribution at jail release is an economical and feasible approach to substantially reducing opioid-related overdose mortality. Training and preparation of proficient and willing bystanders are central factors in reaching the full potential of this intervention.
Comparative Analysis of Indices for Social Determinants of Health in Pediatric Surgical Populations
Authors: Stephens Caroline Q. , Yap Ava , Vu Lan , Saito Jacqueline M. , Barry Dwight , Shui Amy M. , Cockrell Hannah , Cairo Sarah , Wakeman Derek , Berman Loren , Greenberg Sarah , Linden Allison F. , Kohler Jonathan , Tsao KuoJen , Wilson Nicole A. 
Published: December 2024

ImportanceConclusions vary substantially among studies examining associations between area-based social determinants of health (SDOH) and pediatric health disparities based on the selected patient population and SDOH index. Most national studies use zip codes, which encompass a wide distribution of communities, limiting the generalizability of findings.ObjectivesTo characterize the distributions of composite SDOH indices for pediatric surgical patients within a national sample of academic children’s hospitals and to assess SDOH index precision in classifying patients at similar levels of disadvantage.Design, Setting, and ParticipantsThis multicenter retrospective cohort study included patients younger than 18 years who underwent surgery from January 1, 2016, to December 31, 2021, at 8 American College of Surgeons National Surgical Quality Improvement Program Pediatric children’s hospitals. Data were analyzed November 15, 2023, to September 25, 2024.ExposuresExposures included the Social Vulnerability Index (SVI), Area Deprivation Index (ADI), and Child Opportunity Index (COI), which are composite scores of SDOH factors within a geographic area. A standardized, high-fidelity process was developed to link individual patients to SDOH indices at the US census tract and census block group level.Main Outcomes and MeasuresThe primary outcome was composite SDOH index distribution, which was assessed using interrater reliability scores. Substantial agreement was defined as a Cohen κ statistic higher than 0.60.ResultsOf 55 865 included patients, 54.6% were male; 34.8% were infants and toddlers (0-3 years of age), 39.0% were school age (4-12 years), and 26.2% were adolescents (13-17 years). A total of 3468 patients (6.2%) could not be matched to either an SVI, ADI, or COI. Patients with missing geocodes were more likely to be Hispanic (20.1% vs 17.1%; P &amp;lt; .001) and have Medicaid insurance (48.1% vs 44.6%; P &amp;lt; .001) compared with patients with addresses that could be geocoded. With all institutions grouped, SDOH indices showed only minor variations. However, within each institution and among institutions, indices varied considerably, especially the ADI. Indices had low-to-fair interrater reliability within institutions (κ range, 0.15-0.33), indicating that each index classified individual patients differently according to disadvantage.Conclusions and RelevanceIn this multicenter retrospective cohort study of 55 865 pediatric surgical patients, 3 different composite measures of SDOH classified disadvantage for individual patients differently. The SDOH index components should be understood and carefully considered prior to inclusion of a composite measure in the analysis of children’s surgical outcomes.
Transition Metal Dichalcogenide‐Based Composites in Powder Bed Additive Manufacturing for Electrochemical Applications—A Review
Authors: Alinejadian Navid , Odnevall Inger , Meisnar Martina , Jafari Davoud 
Published: December 2024

AbstractRobust electrochemical sustainability of tailored high‐performance nanocomposites is integral to advanced electrochemical energy conversion and storage (EECS) systems. Functions, such as nanoscale ionic‐diffusion distance, electrocatalytic reactions, electrical conductivity, and fluid distribution, of transition metal dichalcogenide (TMD)‐based nanostructures have been extensively designed and studied. However, challenges in materials selection, operational scalability, and design flexibility of TMD‐incorporated metal‐matrix composites (MMCs) consisting of non‐noble metallic nanostructures and their originating TMD materials have scarcely been studied. Highlighting the effectiveness of emerging additive manufacturing techniques in sustainable energy supply and storage, laser powder bed fusion (L‐PBF) can offer a directly added dual‐functionality to fabricated complex multimaterial and TMD‐incorporated MMC electrocatalytic electrodes. In this review, the characteristics of composite powder feedstock and optimizing process parameters are critically emphasized from another perspective to maintain a balance between mechanical robustness and enhanced electrochemical response. It is demonstrated how factors such as surface roughness, particle shape, and rheological characteristics of TMDs can influence the flowability of composite powder feedstock and the electrochemical performance of L‐PBF‐processed electrodes. The review further aims to contribute compiled information for use in the rapidly growing global market for advanced energy storage systems, underscoring the transformative potential of L‐PBF and TMD‐incorporated MMCs in modernizing the EECS components.
The Spiral of Attention, Arousal, and Release: A Comparative Phenomenology of Jhāna Meditation and Speaking in Tongues
Authors: Brahinsky Josh , Mago Jonas , Miller Mark , Catherine Shaila , Lifshitz Michael 
Published: December 2024

ABSTRACTBuddhist Jhāna meditation and the Christian practice of speaking in tongues appear wildly distinct. These spiritual techniques differ in their ethical, theological, and historical frames and seem, from the outside, to produce markedly different states of consciousness—one a state of utter calm and the other of high emotional arousal. Yet, our phenomenological interviews with experienced practitioners in the USA found significant points of convergence. Practitioners in both traditions describe a dynamic relationship between focused attention, aroused joy, and a sense of letting go or release that they describe as crucial to their practice. This paper highlights these shared phenomenological features and theorizes possible underlying mechanisms. Analyzing our phenomenological data through the lens of various theories of brain function, including sensory gating and predictive processing, we propose that these practices both engage an autonomic field built through a spiral between attention, arousal, and release (AAR).
Harnessing Nanomaterials for Enhanced DNA‐Based Biosensing and Therapeutic Performance
Authors: Pan Xumin , Zhao Xiaoman , Lu Yanhong , Xie Ping , Liu Lan , Chu Xia 
Published: December 2024

AbstractThe integration of nanomaterials with DNA‐based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features of DNA, like its programmability and specificity, complement the diverse functions of nanomaterials, leading to the creation of advanced systems for detecting biomarkers and delivering treatments. Here, we review the developments in DNA‐nanomaterial conjugates, emphasizing their enhanced functionalities and potential across various biomedical applications. We first discuss the methodologies for synthesizing these conjugates, distinguishing between covalent and non‐covalent interactions. We then categorize DNA‐nanomaterials conjugates based on the properties of the DNA and nanomaterials involved, respectively. DNA probes are classified by their application into biosensing or therapeutic uses, and, several nanomaterials are highlighted by their recent progress in living biological. Finally, we discuss the current challenges and future prospects in this field, anticipating that significant progress in DNA‐nanomaterial conjugates will greatly enhance precision medicine.
Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review
Authors: Stanton Jacob , Gionfriddo Michael R. , Rattinger Gail B. , Fang Yuan , Lussier Mia E. 
Published: December 2024

AbstractCognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management. Multiple tools exist to help pharmacists and other practitioners identify these medications, yet a comprehensive description of these tools has not been undertaken. We searched EBSCO MEDLINE, PubMed, EMBASE, CINAHL, and PsycInfo from inception to August 4, 2023, using search terms relative to medications and cognition. Studies were included if they detailed a tool to assess the cognitive burden of a medication regimen. Abstracts and full texts were screened independently and in duplicate. Any disagreements at the level of full‐text screening were resolved by consensus. Eligible studies underwent data extraction by two authors independently and in duplicate using a data extraction form. Our search identified 13 126 articles of which only four tools were initially included. Additionally, we identified seven articles from the reference lists of excluded review articles for a final inclusion count of 11 tools. Articles were published between 2001 and 2017. Nine of 11 tools (82%) were focused solely on anticholinergic medications, while only one tool indicated a clinically relevant cutoff value and alternative medication recommendations. While there are many tools to assess the cognitive burden from medications, many are limited by the development date, focus on anticholinergic medications, or lack clinically useful information. Further research is needed to develop more comprehensive, up‐to‐date, and readily implementable tools that clinical pharmacists can utilize to assess medication‐induced cognitive risks. Such as tool could be applied by pharmacists in many settings to optimize medication use and improve patient outcomes.