bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Teachers' Personality Traits Predict Their Performance? A Comprehensive Review of the Empirical Literature From 1990 to 2018
Authors: Kell Harrison J. 
Published: February 2019

AbstractInterest in the relationship between teachers' personality traits and their performance is rising. It is often remarked, however, that the topic has received little research attention. This study surveys what empirical research has been conducted among U.S. K–12 teachers from 1990 to 2018. The search, conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and structured by the Big Five personality taxonomy, uncovered 13 articles. Effect sizes were statistically small, with the most consistent finding being that agreeableness was negatively related to most outcomes across most studies. Implications and future directions for research and practice are discussed.
Evaluation of the impact of different drying methods on the phenolic compounds, antioxidant activity, and in vitro digestion of green coffee beans
Authors: Cheng Ke , Dong Wenjiang , Long Yuzhou , Zhao Jianping , Hu Rongsuo , Zhang Yanjun , Zhu Kexue 
Published: February 2019

AbstractWe investigated the effects of different drying methods (room temperature drying, heat pump drying, freeze drying, microwave vacuum drying [MVD], and combined microwave power vacuum drying) on the active ingredients of green coffee beans. We specifically focused on eleven phenolic acids, total phenolic content (TPC), total flavonoid content, antioxidant activity, polyphenol oxidase (PPO), the inhibition of linoleic acid peroxidation (LPO), and enzyme activity, and the bio‐accessibility in vitro and bioavailability of phenolics and antioxidant activities were also evaluated. MVD‐treated beans had the lowest PPO activity and the highest contents of 5‐caffeoylquinic acid (1.39 g/100 g DW), 3‐feruloylquinic acid (0.25 g/100 g DW), 4‐feruloylquinic acid (0.25 g/100 g DW), 5‐feruloylquinic acid (1.52 g/100 g DW), and TPC (5.98 g GAE/100 g DW), and the highest antioxidant activity. MVD was the least time‐consuming (0.63 hr/kg) and energy‐consuming (1.88 kwh/kg) method. Moreover, the strongest inhibition of LPO and α‐glucosidase was observed in MVD‐treated beans. Thus, MVD is suggested to be the most suitable drying technique for the preservation of phenolic compounds and bioactivities of green coffee beans.
Perioperative changes in superficial pelvic organ prolapse quantification system measurements after prolapse surgery
Authors: Durnea Constantin M. , Basu Maya , Dadhwal Kiran , Gayle Yasmin V. , Gauthaman Nivedita , Khunda Azar , Doumouchtsis Stergios K. 
Published: February 2019

AbstractObjectivesTo evaluate the values of perineal body (PB) and genital hiatus (GH) before and after posterior repair. We also evaluated the introital surface area (ISA)—a sum of transverse and longitudinal GH measurements.MethodsThis secondary analysis of a prospective case series included 94 women undergoing posterior vaginal prolapse surgery at a consultant urogynecology clinic between October 3, 2011, and October 2, 2014. Patients were examined in clinic using the pelvic organ prolapse quantification system with Valsalva maneuver, and in theatre pre‐ and postoperatively with traction.ResultsImmediately postoperatively, a statistically significant change (all P<0.001) was noted for GH (mean difference −0.59 cm), PB (−0.56 cm), and ISA (−0.87 cm) compared with preoperative measurement. This effect was maintained for GH (−0.42 cm) and PB (−0.40 cm) at 2 months’ follow‐up (both P<0.001), and for PB alone (−0.43 cm; P=0.04) at 8 months. ISA had a moderate correlation with GH (r=0.55).ConclusionsPosterior repair significantly improved PB length at months 2 and 8, and GH length at month 2. ISA did not correlate with prolapse stage. Changes in GH were not maintained beyond postoperative month 2.
Mitochondrial dysfunctions in barth syndrome
Authors: Ghosh Sagnika , Iadarola Donna M. , Ball Writoban Basu , Gohil Vishal M. 
Published: February 2019

ABSTRACTBarth syndrome (BTHS) is a rare multisystemic genetic disorder caused by mutations in the TAZ gene. TAZ encodes a mitochondrial enzyme that remodels the acyl chain composition of newly synthesized cardiolipin, a phospholipid unique to mitochondrial membranes. The clinical abnormalities observed in BTHS patients are caused by perturbations in various mitochondrial functions that rely on remodeled cardiolipin. However, the contribution of different cardiolipin‐dependent mitochondrial functions to the pathology of BTHS is not fully understood. In this review, we will discuss recent findings from different genetic models of BTHS, including the yeast model of cardiolipin deficiency that has uncovered the specific in vivo roles of cardiolipin in mitochondrial respiratory chain biogenesis, bioenergetics, intermediary metabolism, mitochondrial dynamics, and quality control. We will also describe findings from higher eukaryotic models of BTHS that highlight a link between cardiolipin‐dependent mitochondrial function and its impact on tissue and organ function. © 2019 IUBMB Life, 9999(9999):1–11, 2019
Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T‐helper 2‐driven proinflammatory responses in a mouse model of allergic dermatitis
Authors: Tajima Hitoshi , Tajiki‐Nishino Risako , Watanabe Yuko , Fukuyama Tomoki 
Published: February 2019

AbstractThe aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that binds to various environmental chemicals and contributes to numerous toxicological effects. However, the direct effects of AhR on the development of allergic diseases are not fully understood. The main aim of this study was to elucidate the action of AhR in the development of cutaneous allergies. Initially, the potential for a direct relationship between AhR and the immune cells was investigated in vitro, using murine bone marrow‐derived dendritic cells, human epidermal keratinocytes, and the mixed leukocyte reaction assay. Benzo[a]pyrene (BaP) and 6‐formylindolo[3,2‐b]carbazole were used as selective ligands for the AhR. Pretreatment with BaP and/or 6‐formylindolo[3,2‐b]carbazole significantly induced cytokine release by activated keratinocytes and T‐cell proliferation, whereas interleukin‐12 production in bone marrow‐derived dendritic cells was reduced by AhR activation. To confirm the in vitro results, in vivo experiments were also performed in T‐helper (Th)2‐type hapten toluene‐2,4‐diisocyanate‐ and Th1‐type hapten dinitrochlorobenzene‐induced mouse models of allergic dermatitis. Mice were orally administered BaP at 48, 24 and 4 hours before the final allergen challenge. In the Th2 model, ear‐swelling response and scratching behavior were promoted by BaP exposure, which supported the observed significant increases in local cytokine secretion. The infiltration of helper T cells, B cells and dendritic cells into the auricular lymph node was significantly enhanced by BaP administration, although Th1‐type immune responses were not influenced by AhR activation. Our findings demonstrate that AhR activation directly activates keratinocytes and T cells, which leads to the exacerbation of Th2‐type cutaneous allergy.
Pharmacokinetics, pharmacodynamics, and safety of moss‐aGalactosidase A in patients with Fabry disease
Authors: Hennermann Julia B. , Arash‐Kaps Laila , Fekete György , Schaaf Andreas , Busch Andreas , Frischmuth Thomas 
Published: February 2019

AbstractMoss‐aGalactosidase A (moss‐aGal) is a moss‐derived version of human α‐galactosidase developed for enzyme replacement therapy in patients with Fabry disease. It exhibits a homogenous N‐glycosylation profile with >90% mannose‐terminated glycans. In contrast to mammalian cell produced α‐galactosidase, moss‐aGal does not rely on mannose‐6‐phosphate receptor mediated endocytosis but targets the mannose receptor for tissue uptake. We conducted a phase 1 clinical trial with moss‐aGal in six patients with confirmed diagnosis of Fabry disease during a 28‐day schedule. All patients received a single dose of 0.2 mg/kg moss‐aGal by i.v.‐infusion. Primary endpoints of the trial were safety and pharmacokinetics; secondary endpoints were pharmacodynamics by analyzing urine and plasma Gb3 and lyso‐Gb3 concentrations. In all patients, the administered single dose was well tolerated. No safety issues were observed. Pharmacokinetic data revealed a stable nonlinear profile with a short plasma half‐life of moss‐aGal of 14 minutes. After one single dose of moss‐aGal, urinary Gb3 concentrations decreased up to 23% 7 days and up to 60% 28 days post‐dose. Plasma concentrations of lyso‐Gb3 decreased by 3.8% and of Gb3 by 11% 28 days post‐dose. These data reveal that a single dose of moss‐aGal was safe, well tolerated, and led to a prolonged reduction of Gb3 excretion. As previously shown, moss‐aGal is taken up via the mannose receptor, which is expressed on macrophages but also on endothelial and kidney cells. Thus, these data indicate that moss‐aGal may target kidney cells. After these promising results, phase 2/3 clinical trials are in preparation.
Variation in the skull morphometry of four taxonomic units of Thrichomys (Rodentia: Echimyidae), from different Neotropical biomes
Authors: Carvalhaes Jeiel G. , Cordeiro‐Estrela Pedro , Hohl Leandro S.L. , Vilela Roberto V. , D'Andrea Paulo S. , Rocha‐Barbosa Oscar 
Published: February 2019

AbstractThe echimyid rodents of the genus Thrichomys vary considerably in their behavior and feeding ecology, reflecting their occurrence in environments as different as the Caatinga, Cerrado, Pantanal, and Chaco biomes. While the genus was originally classified as monospecific, a number of Thrichomys species have been recognized in recent decades, based on morphometric, cytogenetic, and molecular analyses. While Thrichomys is well studied, the variation found in its cranial morphology is poorly understood, given the taxonomic and ecological complexities of the genus. Using a geometric morphometric approach, we characterized the differences found in the cranial morphology of four Thrichomys taxonomic units, including three established species, Thrichomys apereoides, Thrichomys fosteri, and Thrichomys laurentius, and one operational taxonomic unit (OTU), Thrichomys aff. laurentius. No significant differences were found among these units in cranium size, but significant variation was found in skull shape. The Procrustes distances provided a quantification of the differences in the shape of the skull, with the largest distances being found between T. aff. laurentius and T. fosteri in the dorsal view, and between T. aff. laurentius and T. apereoides in the ventral view. A Discriminant Function Analysis (DFA) with cross‐validation determined that the pairings with the highest correct classification were T. aff. laurentius vs. T. apereoides and T. aff. laurentius vs. T. fosteri, in both views. The principal variation in skull shape was found in the posterior region and the zygomatic arch, which may be related to differences in diet.
Nitroxide‐Mediated Polymerization of Bio‐Based Farnesene with a Functionalized Methacrylate
Authors: Luk Sharmaine B. , Marić Milan 
Published: February 2019

AbstractFarnesene (Far) is a bio‐based terpene monomer that is similar in structure to commercially used dienes like butadiene and isoprene. Nitroxide‐mediated polymerization (NMP) is adept for the polymerization of dienes, but not particularly effective at controlling the polymerization of methacrylates using commercial nitroxides. In this study, Far is statistically copolymerized with a functional methacrylate, glycidyl methacrylate (GMA), by NMP using N‐succinimidyl modified commercial BlocBuilder (NHS‐BB) initiator. Reactivity ratios are determined to be r
Far = 0.54 ± 0.04 and r
GMA = 0.24 ± 0.02. The ability of the poly(Far‐stat‐GMA) chains to reinitiate for chain extension with styrene showed a clear shift in molecular weight and monomodal distribution. Copolymerizations using a new alkoxyamine, Dispolreg 007 (D7), is explored as it is shown to homopolymerize methacrylates, but not yet reported for statistical copolymerizations. Bimodal molecular weight distributions are observed when an equimolar ratio of Far and GMA is copolymerized with D7 due to slow decomposition of the initiator, but chain ends are active as shown by successful chain extension with styrene. Both NHS‐BB and D7 initiators are used to synthesize poly[Far‐b‐(GMA‐stat‐Far)] and poly(Far‐b‐GMA) diblock copolymers. While the NHS‐BB initiated polymer chains have lower dispersity, D7 exhibits more linear polymerization kinetics and maintains more active chain ends.
Prevalence of drug use among adults with intellectual disabilities compared with drug use in the general population
Authors: Hove Oddbjørn , Biringer Eva , Havik Odd E. , Assmus Jörg , Braatveit Kirsten J. , Holm Silje Elisabeth Hasmo , Hermann Monica 
Published: February 2019

AbstractPurposeIndividuals with intellectual disabilities (IDs) have more health problems, a poorer general health, and a shorter life expectancy than individuals in general. High rates of drug use in IDs have been reported. Despite the increasing interest in health problems in individuals with IDs, little is known about their drug use.MethodDrug use in a community sample of adults with IDs (N = 593) was compared with dispensed drugs in a time‐, age‐, and region‐matched comparison group of adults in Western Norway (N = 289 325). A logistic regression model was employed by using the main group effect to describe and analyze the differences between the ID sample and the comparison sample and by using the interaction term (group × age) to describe the rate change differences from the reference age (18‐30 years) between the two groups.ResultsTotal drug use in the ID sample was 62% compared with 50% in the reference sample (P = 0.0001). The high prevalence of drugs for the nervous system (ATC N) in the ID sample (50%) explained the difference. From age 51 and over, the increase in the drug use rate for the cardiovascular disease was significantly lower in the ID sample than in the reference sample (P value range: 0.002‐0.019).ConclusionsAdults with IDs use more drugs than adults in general. However, the findings showed lower rates of drug use in the ID sample than in the general population for drugs targeting diseases that are the leading causes of death in individuals with IDs.
Isomer Structural Transformation in Au–Cu Alloy Nanoclusters: Water Ripple‐Like Transfer of Thiol Ligands
Authors: Yu Wei , Hu Daqiao , Xiong Lin , Li Yangfeng , Kang Xi , Chen Shuang , Wang Shuxin , Pei Yong , Zhu Manzhou 
Published: February 2019

AbstractStructure isomerism is observed in noble metal nanoclusters; however, the mechanism study of this process is rarely reported. Herein, by using the biphosphine ligands instead of phosphine ligands, the high symmetry of the Au2Cu6(PPh3)2(SAdm)6 nanocluster is successfully broken and [Au4Cu4(L1)2(SAdm)5]Br (where, L1 is bis(diphenylphosphine)methane, DPPM) nanocluster is obtained with chiral arrangement. This newly obtained nanocluster contains a total of four isomers in crystal unit cell. Interestingly, these isomers undergo rapid isomorphism in solution, which is confirmed by 1H‐1H COSY spectrum. Density functional theory calculations demonstrate that the water ripple–like transfer of the thiol ligands results from the isomorphism of nanoclusters.
Coadministration of epigallocatechin‐3‐gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats
Authors: Yang Zhe , Zhu Ming‐zhi , Zhang Yang‐bo , Wen Bei‐bei , An Hui‐min , Ou Xing‐chang , Xiong Yi‐fan , Lin Hai‐yan , Liu Zhong‐hua , Huang Jian‐an 
Published: February 2019

Epigallocatechin‐3‐gallate (EGCG) and caffeine in tea exert anti‐obesity effects and induces nonalcoholic fatty liver disease (NAFLD) amelioration. However, previous studies usually performed a high‐dose EGCG administration, whereas the insecurity was arisen in recent researches. In this study, we treated obese rats with an elaborate dose—40 mg/kg EGCG, 20 mg/kg caffeine, and the coadministration of them as low dose, which were similar to the daily intake; 160 mg/kg EGCG as high dose, which was the maximum safe dose had touched the contentious edge. The results suggested that the coadministration of EGCG and caffeine exerted more remarkable function on suppressing body weight gain, reducing white adipose tissue weight and decreasing the energy intake than single use. This may be due to the variation in serum lipid profile, oxidative stress, and adipose‐derived and inflammatory cytokines. The pathological micrographs showed long‐term high‐fat diets caused severe NAFLD, but it was ameliorated at different levels by all of the administrations. In summary, low dose of EGCG or caffeine only showed a mild effect of anti‐obesity and NAFLD amelioration. The coadministration of them could exert a superior curative effect as well as high dose EGCG but no anxiety regarding safety.
Annexin A2 extracellular translocation and virus interaction: A potential target for antivirus‐drug discovery
Authors: Aliyu Isah Abubakar , Ling King‐Hwa , Md Hashim Nurfariesha , Chee Hui‐Yee 
Published: February 2019

SummaryAnnexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+‐dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid‐raft microdomain formation. However, upon cell exposure to certain stimuli, annexin A2 translocates to the external leaflets of the plasma membrane where annexin A2 was recently reported to serve as a virus receptor, play an important role in the formation of virus replication complex, or implicated in virus assembly and budding. Here, we review some of annexin A2 roles in virus infections and the potentiality of targeting annexin A2 in the design of novel and promising antivirus agent that may have a broader consequence in virus therapy.
Structural and functional similarities in bunyaviruses: Perspectives for pan‐bunya antivirals
Authors: ter Horst Sebastiaan , Conceição‐Neto Nádia , Neyts Johan , Rocha‐Pereira Joana 
Published: February 2019

SummaryThe order of Bunyavirales includes numerous (re)emerging viruses that collectively have a major impact on human and animal health worldwide. There are no vaccines for human use or antiviral drugs available to prevent or treat infections with any of these viruses. The development of efficacious and safe drugs and vaccines is a pressing matter. Ideally, such antivirals possess pan‐bunyavirus antiviral activity, allowing the containment of every bunya‐related threat. The fact that many bunyaviruses need to be handled in laboratories with biosafety level 3 or 4, the great variety of species and the frequent emergence of novel species complicate such efforts. We here examined the potential druggable targets of bunyaviruses, together with the level of conservation of their biological functions, structure, and genetic similarity by means of heatmap analysis. In the light of this, we revised the available models and tools currently available, pointing out directions for antiviral drug discovery.
ZnO Zeolite Nanocomposite for Photocatalytic Elimination of Benzophenone and Caffeine
Authors: Jagannatha Rajesha Bedre , Rani R Shwetha , Padaki Mahesh 
Published: February 2019

AbstractEmerging contaminants in the aquatic environment, including pharmaceuticals and personal care products (PPCPs) are mainly resulting from the release of municipal wastewater effluents, which are detected at surface water with lower concentration, and these compounds have an impact on aquatic life. The present research investigates the preparation of zeolite supported ZnO for degradation of pharmaceuticals and personal care products like benzophenone and caffeine. Incorporation of zeolite enhances the adsorption capacity there by results in improved degradation of PPCPs. The prepared materials were characterised by XRD, SEM, EDS, UV and ICP‐OES to confirm the impregnation of ZnO in the zeolite powder, which showed 85% caffeine degradation and 78% of BP‐3 degradation with an optimum catalyst load of 70 mg.
Direct Imaging of the Induced‐Fit Effect in Molecular Self‐Assembly
Authors: Yang Zechao , Lotze Christian , Corso Martina , Baum Sebastian , Franke Katharina J. , Pascual José I. 
Published: February 2019

AbstractMolecular recognition is a crucial driving force for molecular self‐assembly. In many cases molecules arrange in the lowest energy configuration following a lock‐and‐key principle. When molecular flexibility comes into play, the induced‐fit effect may govern the self‐assembly. Here, the self‐assembly of dicyanovinyl‐hexathiophene (DCV6T) molecules, a prototype specie for highly efficient organic solar cells, on Au(111) by using low‐temperature scanning tunneling microscopy and atomic force microscopy is investigated. DCV6T molecules assemble on the surface forming either islands or chains. In the islands the molecules are straight—the lowest energy configuration in gas phase—and expose the dicyano moieties to form hydrogen bonds with neighbor molecules. In contrast, the structure of DCV6T molecules in the chain assemblies deviates significantly from their gas‐phase analogues. The seemingly energetically unfavorable bent geometry is enforced by hydrogen‐bonding intermolecular interactions. Density functional theory calculations of molecular dimers quantitatively demonstrate that the deformation of individual molecules optimizes the intermolecular bonding structure. The intermolecular bonding energy thus drives the chain structure formation, which is an expression of the induced‐fit effect.
Seismic response of self‐centering precast concrete frames with hysteretic dampers
Authors: Li Yadong , Ding Youliang , Geng Fangfang , Wang Libin 
Published: February 2019

SummaryWith the rapid development of cities and the invasion of major natural disasters such as earthquakes, the resilience city as a new design concept has been paid more and more attention. As an important branch of self‐centering seismic resisting system, self‐centering concrete frame system has been studied by many scholars. These studies prove that self‐centering concrete frame structure has excellent self‐centering ability but poor energy dissipation capacity. Adhering to the working principle of self‐centering structure and considering the development concepts of building industrialization and modularization, this paper proposed a kind of self‐centering precast concrete frame with hysteretic damper (SCPCHD). In order to verify its energy dissipation capacity and seismic performance, elaborate finite element models were established and elastoplastic dynamic time history analyses were carried out. The results showed that the SCPCHD frame has a similar interstory displacement response to the reinforced concrete (RC) frame and the energy dissipation performance of its joint is obviously superior to the RC frame under rare earthquake because the SCPCHD frame has low damage characteristics and excellent damping device. In summary, this paper proves the feasibility and superiority of the SCPCHD frame, providing reliable support for further research.