bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis of global publications in medication adherence (1900–2017)
Authors: Sweileh Waleed M , Al-Jabi Samah W , Zyoud Sa’ed H , Shraim Nasr Y , Anayah Fathi M A , Sawalha Ansam F , AbuTaha Adham S 
Published: July 2018

Abstract

Objectives
Medication non-adherence is a worldwide problem. The aim of this study was to assess the global research output, research trends and topics that shaped medication adherence research.

Methods
A bibliometric methodology was applied. Keywords related to ‘medication adherence’ were searched in Scopus database for all times up to 31 December 2017. Retrieved data were analyzsd, and bibliometric indicators and maps were presented.

Key findings
In total, 16 133 documents were retrieved. Most frequently encountered author keywords, other than adherence/compliance, were HIV, hypertension, diabetes mellitus, schizophrenia, depression, osteoporosis, asthma and quality of life. The number of documents published from 2008 to 2017 represented 62.0% (n = 10 005) of the total retrieved documents. The h-index of the retrieved documents was 223. The USA ranked first (43.1%; n = 6959), followed by the UK (8.6%; n = 1384) and Canada (4.5%; n = 796). The USA dominated the lists of active authors and institutions. Top active journals in publishing research on medication adherence were mainly in the field of AIDS. Top-cited articles in the field focused on adherence to anti-HIV medications, the impact of depression on medication adherence and barriers to adherence.

Conclusion
Adherence among HIV patients dominated the field of medication adherence. Research on medication adherence needs to be strengthened in all countries and in different types of chronic diseases. Research collaboration should also be encouraged to increase research activity on medication adherence in developing countries.
Magnetic resonance imaging 3T and total fibrotic volume in autosomal dominant polycystic kidney disease
Authors: Lai Silvia , Mastroluca Daniela , Letizia Claudio , Petramala Luigi , Perrotta Adolfo M. , DiGaeta Alessandro , Ferrigno Luigina , Ciccariello Mauro , D'Angelo Anna R. , Panebianco Valeria 
Published: July 2018

AbstractBackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD.AimTo identify and quantify ADPKD, through a novel magnetic resonance imaging protocol with 3 Tesla (MRI 3Tesla), the presence of parenchymal fibrotic tissue at early stage of disease, able to correlate the glomerular filtrate and to predict the loss of the renal function.MethodsA total of 15 ADPKD patients had undergone renal testing on MRI 3Tesla at T0 and were revaluated after follow up (T1) of 5 years. We have evaluated renal function, plasma aldosterone concentration (PAC), insulin resistance and surrogate markers of atherosclerosis (carotid intima‐media thickness, ankle/brachial index (ABI) and left ventricular mass index (LVMI).ResultsOur study showed a significant negative correlation between total kidney volume (TKV) and estimated glomerular filtration rate (eGFR) during observation (P < 0.02). We showed a negative correlation between eGFR with total fibrotic volume (TFV) (P < 0.04) and total perfusion volume/TKV (P < 0.02). Moreover TFV was correlated positively with PAC (P < 0.05), insulin values (P < 0.05), ABI (P < 0.05) and LVMI (P < 0.01).ConclusionThe MRI 3Tesla, despite the high costs, could be considered as a useful and non‐invasive method in the evaluation of fibrotic tissue and progression of the disease in ADPKD patients. Further clinical trials on larger groups are due to confirm the results of this pilot study, suggesting that MRI 3Tesla can be useful to evaluate the effectiveness of new therapeutic strategies.
Advance care planning documentation strategies; goals‐of‐care as an alternative to not‐for‐resuscitation in medical and oncology patients. A pre–post controlled study on quantifiable outcomes
Authors: Morgan David J. R. , Eng Derek , Higgs Dominic , Beilin Maria , Bulsara Caroline , Wong Milly , Angus Louise , Waldron Nicholas 
Published: July 2018

AbstractBackgroundHealth services in Tasmania, Victoria and now Western Australia are changing to goals‐of‐care (GOC) advance care planning (ACP) documentation strategies.AimTo compare the clinical impact of two different health department‐sanctioned ACP documentation strategies.MethodsA non‐blinded, pre–post, controlled study over two corresponding 6‐month periods in 2016 and 2017 comparing the current discretional not‐for‐resuscitation (NFR) with a new, inclusive GOC strategy in two medical/oncology wards at a large private hospital. Main outcomes were the uptake of ACP forms per hospitalisation and the timing between hospital admission, ACP form completion and in‐patient death. Secondary outcomes included utilisation of the rapid response team (RRT), palliative and critical care services.ResultsIn total, 650 NFR and 653 GOC patients underwent 1885 admissions (mean Charlson Comorbidity Index = 3.7). GOC patients had a higher uptake of ACP documentation (346 vs 150 ACP forms per 1000 admissions, P < 0.0001) and a higher proportion of ACP forms completed within the first 48 h of admission (58 vs 39%, P = 0.0002) but a higher incidence of altering the initial ACP level of care (P = 0.003). All other measures, including ACP documentation within 48 h of death (P = 0.50), activation of RRT (P = 0.73) and admission to critical (P = 0.62) or palliative (P = 0.81) care services, remained similar. GOC documentation was often incomplete, with most sub‐sections left blank between 74 and 87% of occasions.ConclusionDespite an increased uptake of the GOC form, overall use remained low, written completion was poor, and most quantitative outcomes remained statistically unchanged. Further research is required before a wider GOC implementation can be supported in Australia's healthcare systems.
Nonannual seasonality of influenza‐like illness in a tropical urban setting
Authors: Lam Ha Minh , Wesolowski Amy , Hung Nguyen Thanh , Nguyen Tran Dang , Nhat Nguyen Thi Duy , Todd Stacy , Vinh Dao Nguyen , Vy Nguyen Ha Thao , Thao Tran Thi Nhu , Thanh Nguyen Thi Le , Tin Phan Tri , Minh Ngo Ngoc Quang , Bryant Juliet E. , Buckee Caroline O. , Ngoc Tran Van , Chau Nguyen Van Vinh , Thwaites Guy E. , Farrar Jeremy , Tam Dong Thi Hoai , Vinh Ha , Boni Maciej F. 
Published: July 2018

AbstractBackgroundIn temperate and subtropical climates, respiratory diseases exhibit seasonal peaks in winter. In the tropics, with no winter, peak timings are irregular.MethodsTo obtain a detailed picture of influenza‐like illness (ILI) patterns in the tropics, we established an mHealth study in community clinics in Ho Chi Minh City (HCMC). During 2009‐2015, clinics reported daily case numbers via SMS, with a subset performing molecular diagnostics for influenza virus. This real‐time epidemiology network absorbs 6000 ILI reports annually, one or two orders of magnitude more than typical surveillance systems. A real‐time online ILI indicator was developed to inform clinicians of the daily ILI activity in HCMC.ResultsFrom August 2009 to December 2015, 63 clinics were enrolled and 36 920 SMS reports were received, covering approximately 1.7M outpatient visits. Approximately 10.6% of outpatients met the ILI case definition. ILI activity in HCMC exhibited strong nonannual dynamics with a dominant periodicity of 206 days. This was confirmed by time series decomposition, stepwise regression, and a forecasting exercise showing that median forecasting errors are 30%‐40% lower when using a 206‐day cycle. In ILI patients from whom nasopharyngeal swabs were taken, 31.2% were positive for influenza. There was no correlation between the ILI time series and the time series of influenza, influenza A, or influenza B (all P > 0.15).ConclusionThis suggests, for the first time, that a nonannual cycle may be an essential driver of respiratory disease dynamics in the tropics. An immunological interference hypothesis is discussed as a potential underlying mechanism.
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression
Authors: Qin Dan‐dan , Yang Ying‐feng , Pu Ze‐qing , Liu Dong , Yu Cong , Gao Peng , Chen Ji‐cui , Zong Chen , Zhang Yu‐chao , Li Xia , Wang Xiang‐dong , Liu Yuan‐tao 
Published: July 2018

AbstractNuclear receptor subfamily 4 group A member 1 (NR4A1) is an orphan nuclear receptor with diverse functions. It has been reported that NR4A1, as a transcriptional activator, is implicated in glucose and lipid metabolism. The aim of this study was to investigate the regulatory role of NR4A1 in adipogenesis and explore the underlying mechanisms. Quantitative real‐time PCR and Western blotting were used to analyse the expression of genes involved in synthesis and mobilization of fats in vivo and in vitro. Dual‐luciferase reporter assay was conducted to study the regulatory mechanisms of NR4A1. Our data from in vivo study confirmed that NR4A1 knockout (KO) mice fed with high‐fat diet were more prone to obesity, and gene expression levels of PPARγ and FAS were increased in KO mice compared to controls; our data from in vitro study showed that NR4A1 overexpression in 3T3‐L1 pre‐adipocytes inhibited adipogenesis. Moreover, NR4A1 enhanced GATA binding protein 2 (GATA2) expression, which in turn inhibited peroxisome proliferator‐activated receptor γ (PPARγ); NR4A1 inhibited sterol regulatory element binding transcription factor 1 (SREBP1) and its downstream gene fatty acid synthase (FAS) by up‐regulating p53. NR4A1 inhibits the differentiation and lipid accumulation of adipocytes by enhancing the expression of GATA2 and p53.
A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs
Authors: Jiang Wen‐yan , Xing Chun , Wang Hong‐wei , Wang Wei , Chen Su‐zhen , Ning Liu‐fang , Xu Xu , Tang Qi‐qun , Huang Hai‐yan 
Published: July 2018

AbstractAccelerated marrow adipogenesis has been associated with ageing and osteoporosis and is thought to be because of an imbalance between adipogenic and osteogenic differentiation of mesenchymal stem cell (MSCs). We have previously found that lysyl oxidase (Lox) inhibition disrupts BMP4‐induced adipocytic lineage commitment and differentiation of MSCs. In this study, we found that lox inhibition dramatically up‐regulates BMP4‐induced expression of CCAAT/enhancer binding protein (C/EBP) homologous protein 10 (CHOP‐10), which then promotes BMP4‐induced osteogenesis of MSCs both in vitro and in vivo. Specifically, Lox inhibition or CHOP‐10 up‐regulation activated Wnt/β‐catenin signalling to enhance BMP4‐induced osteogenesis, with pro‐adipogenic p38 MAPK and Smad signalling suppressed. Together, we demonstrate that Lox/CHOP‐10 crosstalk regulates BMP4‐induced osteogenic and adipogenic fate determination of MSCs, presenting a promising therapeutic target for osteoporosis and other bone diseases.
Type 2 diabetes mellitus and neighborhood deprivation index: A spatial analysis in Zhejiang, China
Authors: Zhang Xin , Chen Xiaoxiao , Gong Weiwei 
Published: July 2018

AbstractAims/IntroductionMany studies have reported that socioeconomically disadvantaged people or people who live in deprived areas are more vulnerable to diabetes complications. However, few such studies were carried out in China. The present study examined the spatial association between the incidence of type 2 diabetes mellitus and neighborhood deprivation in Zhejiang, China, from a spatial epidemiology perspective.Materials and MethodsType 2 diabetes mellitus data (2012–2016) in the present study were derived from a population‐based diabetes registry system maintained by Zhejiang Provincial Center for Disease Control and Prevention. Principal components analysis was used to combine different socioeconomic variables together into a composited Neighborhood Deprivation Index. We applied the global Moran's I and Anselin's local Moran's I statistics to explore the spatial patterns of type 2 diabetes mellitus incidence and Neighborhood Deprivation Index.ResultsType 2 diabetes mellitus incidence (Moran's I: 0.531, P < 0.001) and Neighborhood Deprivation Index (Moran's I: 0.772, P < 0.001) showed positive statistically significant global Moran's I index values, showing a tendency towards clustering. The local Moran's I analyses showed that type 2 diabetes mellitus incidence hot spots were mainly located in urban centers, and type 2 diabetes mellitus incidence cold spots appeared in the provincial capital area (Hangzhou city) and western and south‐western regions of Zhejiang; the hot spots of the less deprived areas were concentrated in urban centers (except Lishui city), and the cold spots of the most deprived areas were clustered in western and south‐western regions of Zhejiang.ConclusionsThe study showed that the incidence of type 2 diabetes mellitus was higher in affluent areas than the deprived areas across the study period. It will be significant to focus preventive efforts on the least deprived areas.
Mortgage Default during the U.S. Mortgage Crisis
Authors: SCHELKLE THOMAS 
Published: July 2018

AbstractWhich theory can quantitatively explain the rise in mortgage defaults during the U.S. mortgage crisis? This paper finds that the double‐trigger hypothesis, which attributes mortgage default to the joint occurrence of negative equity and a life event such as unemployment, is consistent with the evidence. By contrast, a traditional frictionless default model strongly overpredicts the increase in default rates. This paper provides microfoundations for double‐trigger behavior in a model where unemployment causes liquidity problems for the borrower. This framework implies that mortgage crises may be mitigated at a lower cost by bailing out borrowers instead of lenders.
Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology
Authors: Michno Wojciech , Wehrli Patrick M. , Blennow Kaj , Zetterberg Henrik , Hanrieder Jörg 
Published: July 2018

AbstractRecent advances in the understanding of basic pathological mechanisms in various neurological diseases depend directly on the development of novel bioanalytical technologies that allow sensitive and specific chemical imaging at high resolution in cells and tissues. Mass spectrometry‐based molecular imaging (IMS) has gained increasing popularity in biomedical research for mapping the spatial distribution of molecular species in situ. The technology allows for comprehensive, untargeted delineation of in situ distribution profiles of metabolites, lipids, peptides and proteins. A major advantage of IMS over conventional histochemical techniques is its superior molecular specificity. Imaging mass spectrometry has therefore great potential for probing molecular regulations in CNS‐derived tissues and cells for understanding neurodegenerative disease mechanism. The goal of this review is to familiarize the reader with the experimental workflow, instrumental developments and methodological challenges as well as to give a concise overview of the major advances and recent developments and applications of IMS‐based protein and peptide profiling with particular focus on neurodegenerative diseases.This article is part of the Special Issue “Proteomics”.
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Occurrence of Christella (Thelypteridaceae) in Southwest China and its indications of the paleoenvironment of the Qinghai–Tibetan Plateau and adjacent areas
Authors: Xu Cong‐Li , Su Tao , Huang Jian , Huang Yong‐Jiang , Li Shu‐Feng , Zhao Yi‐Shan , Zhou Zhe‐Kun 
Published: July 2018

AbstractThe uplift of the Qinghai–Tibetan Plateau dramatically changed the regional topography and climate, profoundly impacting the distribution of many plant lineages. Plant responses to environmental changes are particularly prominent in lineages that require ecological factors differentiated from those present before the uplift of the QTP. Two fossil occurrences of Christella H. Lév., Fl. Kouy–Tchéou (Thelypteridaceae), a fern genus now distributed mainly at low elevations of the pantropics with warm and moist habitats, are described based on fossilized Cenozoic leaf fronds recovered from SW China: late Paleocene Christella nervosa (J. R. Tao) C. L. Xu, T. Su & Z. K. Zhou comb. nov. found in Liuqu, southern Tibet and middle Miocene Christella sp. recovered from the Jinggu Basin in western Yunnan. The frond fossils from both sites share key morphological characteristics that diagnose these fossils as Christella. After detailed comparisons, we further clarified Christella papilio (C. Hope) Holttum, a species distributed in warm, humid habitats at altitudes no more than 1300 m, as the nearest living relative of C. nervosa. This finding suggested that southern Tibet had not reached its present elevation during the late Paleocene (ca. 56 Ma). We propose that the uplift, accompanied by severe cooling and aridification after the late Paleocene, caused the disappearance of Christella in southern Tibet, whereas paleoenvironmental conditions enabled the genus to survive in Yunnan. Our study provides the first example of distributional constraints of ferns in SW China in response to paleoenvironmental changes in the Qinghai–Tibetan Plateau and nearby areas.
Effects of the removal or reduction in density of the malaria mosquito, Anopheles gambiae s.l., on interacting predators and competitors in local ecosystems
Authors: Collins C. M. , Bonds J. A. S. , Quinlan M. M. , Mumford J. D. 
Published: July 2018

AbstractNew genetic control methods for mosquitoes may reduce vector species without direct effects on other species or the physical environment common with insecticides or drainage. Effects on predators and competitors could, however, be a concern as Anopheles gambiae s.l. is preyed upon in all life stages. We overview the literature and assess the strength of the ecological interactions identified. Most predators identified consume many other insect species and there is no evidence that any species preys exclusively on any anopheline mosquito. There is one predatory species with a specialisation on blood‐fed mosquitoes including An. gambiae s.l.. Evarcha culicivora is a jumping spider, known as the vampire spider, found around Lake Victoria. There is no evidence that these salticids require Anopheles mosquitoes and will readily consume blood‐fed Culex. Interspecific competition studies focus on other mosquitoes of larval habitats. Many of these take place in artificial cosms and give contrasting results to semi‐field studies. This may limit their extrapolation regarding the potential impact of reduced An. gambiae numbers. Previous mosquito control interventions are informative and identify competitive release and niche opportunism; so while the identity and relative abundance of the species present may change, the biomass available to predators may not.
Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets
Authors: Werth Emily G. , McConnell Evan W. , Couso Lianez Inmaculada , Perrine Zoee , Crespo Jose L. , Umen James G. , Hicks Leslie M. 
Published: July 2018

Summary

Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress. Key proteins involved in the pathway are conserved in the model photosynthetic microalga Chlamydomonas reinhardtii, but the substrates of TOR kinase and downstream signaling network have not been elucidated. Our study provides a new resource for investigating the phosphorylation networks governed by the TOR kinase pathway in Chlamydomonas.

We used quantitative phosphoproteomics to investigate the effects of inhibiting Chlamydomonas TOR kinase on dynamic protein phosphorylation. Wild‐type and AZD‐insensitive Chlamydomonas strains were treated with TOR‐specific chemical inhibitors (rapamycin, AZD8055 and Torin1), after which differentially affected phosphosites were identified.

Our quantitative phosphoproteomic dataset comprised 2547 unique phosphosites from 1432 different proteins. Inhibition of TOR kinase caused significant quantitative changes in phosphorylation at 258 phosphosites, from 219 unique phosphopeptides.

Our results include Chlamydomonas homologs of TOR signaling‐related proteins, including a site on RPS6 with a decrease in phosphorylation. Additionally, phosphosites on proteins involved in translation and carotenoid biosynthesis were identified. Follow‐up experiments guided by these phosphoproteomic findings in lycopene beta/epsilon cyclase showed that carotenoid levels are affected by TORC1 inhibition and carotenoid production is under TOR control in algae.
Sediment‐encased maturation: a novel method for simulating diagenesis in organic fossil preservation
Authors: Saitta Evan T. , Kaye Thomas G. , Vinther Jakob 
Published: July 2018

AbstractExceptional fossils can preserve diagenetically‐altered biomolecules. Understanding the pathways that lead to such preservation is vital to utilizing fossil information in evolutionary and palaeoecological studies. Experimental taphonomy explores the stability of tissues during microbial/autolytic decay or their molecular stability through maturation under high pressure and temperature. Maturation experiments often take place inside sealed containers, preventing the loss of labile, mobile or volatile molecules. However, wrapping tissues inside aluminium foil, for example, can create too open a system, leading to loss of both labile and recalcitrant materials. We present a novel experimental procedure for maturing tissues under elevated pressure/temperature inside compacted sediment. In this procedure, porous sediment allows maturation breakdown products to escape into the sediment and maturation chamber, while recalcitrant, immobile components are contained, more closely mimicking the natural conditions of fossilization. To test the efficacy of this procedure in simulating fossil diagenesis, we investigate the differential survival of melanosomes relative to proteinaceous tissues through maturation of fresh lizard body parts and feathers. Macro‐ and ultrastructures are then compared to fossils. Similar to many carbonaceous exceptional fossils, the resulting organic components are thin, dark films composed mainly of exposed melanosomes resting on the sediment in association with darkened bones. Keratinous, muscle, collagenous and adipose tissues appear to be lost. Such results are consistent with predictions derived from non‐sediment‐encased maturation experiments and our understanding of biomolecular stability. These experiments also suggest that organic preservation is largely driven by the original molecular composition of the tissue and the diagenetic stability of those molecules, rather than the tissue's decay resistance alone; this should be experimentally explored in the future.