bluuebunny/crossref_metadata_2025_split huggingface dataset:
The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma
Authors: Giacomini Arianna , Taranto Sara , Gazzaroli Giorgia , Faletti Jessica , Capoferri Davide , Marcheselli Raffaella , Sciumè Margherita , Presta Marco , Sacco Antonio , Roccaro Aldo M. 
Published: November 2024

AbstractAmong blood cancers, multiple myeloma (MM) represents the second most common neoplasm and is characterized by the accumulation and proliferation of monoclonal plasma cells within the bone marrow. Despite the last few decades being characterized by the development of different therapeutic strategies against MM, at present such disease is still considered incurable. Although MM is highly heterogeneous in terms of genetic and molecular subtypes, about 67% of MM cases are associated with abnormal activity of the transcription factor c-Myc, which has so far revealed a protein extremely difficult to target. We have recently demonstrated that activation of fibroblast growth factor (FGF) signaling protects MM cells from oxidative stress-induced apoptosis by stabilizing the oncoprotein c-Myc. Accordingly, secretion of FGF ligands and autocrine activation of FGF receptors (FGFR) is observed in MM cells and FGFR3 genomic alterations represent some 15–20% MM cases and are associated with poor outcome. Thus, FGF/FGFR blockade may represent a promising strategy to indirectly target c-Myc in MM. On this basis, the present review aims at providing an overview of recently explored connections between the FGF/FGFR system and c-Myc oncoprotein, sustaining the therapeutic potential of targeting the FGF/FGFR/c-Myc axis in MM by using inhibitors targeting FGF ligands or FGF receptors. Importantly, the provided findings may represent the rationale for using FDA approved FGFR TK inhibitors (i.e. Pemigatinib, Futibatinib, Erdafitinib) for the treatment of MM patients presenting with an aberrant activation of this axis.
In vitro effectiveness of CB469, a MET tyrosine kinase inhibitor in MET-activated cancer cells
Authors: Song Ji Yeon , An Hyunsook , Kim Soojeong 
Published: November 2024

AbstractGene alterations in receptor tyrosine kinases can result in oncogenic driver mutation in non-small cell lung cancer (NSCLC) including in genes like EGFR, ALK and MET. MET amplifications and MET exon14 skipping are the primary genetic changes in MET-altered cancers. Acquired MET mutations mediate resistance to clinical MET-targeted therapy in NSCLC. MET kinase domain secondary mutations (D1228X, Y1230X) confer resistance to type I MET tyrosine kinase inhibitors (TKIs) in METexon14-altered or MET amplified NSCLC. Here, we investigated the preclinical activity of a novel MET inhibitor, CB469, with cell growth, signaling pathway and colony formation. We confirmed that CB469 inhibited the activity of MET wild and secondary mutant kinases, D1228N and Y1230H, as a type II inhibitor. CB469 also inhibited cell growth and cell signaling proteins in MET-activated or MET exon14 skipping-mutated cancer cell lines and NIH/3T3 cells expressing an engineered MET mutant. CB469 exhibited the inhibitory efficacy comparable with that of capmatinib in migration of EBC-1(METwt) and Hs746T(METΔex14) cells. Finally, CB469 showed selective and potent inhibition in MET-activated cancer cells among MET TKIs leading to enhanced selectivity for MET-mutant versus wild type MET with inhibition of cell growth in NIH/3T3 cells expressing an engineered MET mutant variant.
Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance
Authors: Sun Kai , Zhi Yuan , Ren Wenhao , Li Shaoming , Zheng Jingjing , Gao Ling , Zhi Keqian 
Published: November 2024

AbstractDeveloping resistance to cancer treatments is a major challenge, often leading to disease recurrence and metastasis. Understanding the underlying mechanisms of therapeutic resistance is critical for developing effective strategies. O-GlcNAcylation, a post-translational modification that adds GlcNAc from the donor UDP-GlcNAc to serine and threonine residues of proteins, plays a crucial role in regulating protein function and cellular signaling, which are frequently dysregulated in cancer. Similarly, ubiquitination, which involves the attachment of ubiquitin to to proteins, is crucial for protein degradation, cell cycle control, and DNA repair. The interplay between O-GlcNAcylation and ubiquitination is associated with cancer progression and resistance to treatment. This review discusses recent discoveries regarding the roles of O-GlcNAcylation and ubiquitination in cancer resistance, their interactions, and potential mechanisms. It also explores how targeting these pathways may provide new opportunities to overcome cancer treatment resistance in cancer, offering fresh insights and directions for research and therapeutic development.
Effects of teacher students’ study progress on their gaze behavior while solving of an economics knowledge test
Authors: Brückner Sebastian , Zlatkin-Troitschanskaia Olga 
Published: November 2024

AbstractPositive effects of study progress on the economic knowledge of bachelor students are evident and were often referred to as proof of the validity of tests in the context of a longitudinal analysis. However, differences between domain-specific (e.g., semester) or discipline-specific (e.g., attended courses) indicators of study progress on students’ solving the economics tasks are relevant for both diagnostic and instructional purposes, but have hardly been researched to date. In an eye tracking study, we therefore calculated the average fixation duration during 900 task-solving processes of 35 economics teacher students solving 25 single-choice economics tasks. A multi-level mediation analysis shows that both indicators (i.e., semester and attended courses) were positively correlated with economics knowledge. At the same time, the impact of semesters and courses attended on their test performance was partially mediated by average fixation duration on the attractor and distractors, respectively. This suggests that visual attention differs during the task-solving process depending on the domain- or discipline-specific indicator of study progress.
Feasibility of coaxial deep borehole heat exchangers in southern California
Authors: Chen Haohua , Tomac Ingrid 
Published: November 2024

AbstractThis paper investigates the feasibility of coaxial deep borehole heat exchanger (CDBHE) applications to the University of California San Diego (UCSD) campus. By collecting different geophysical source data for various formations and well logs around the UCSD campus, a multilayered thermophysical model for the ground on the site is established. Water circulation within a closed coaxial loop system considers the geothermal energy extraction under uncertainty consideration of the unknown deeper layers heat flow gradient as coupled with the variation of pipe insulation properties, flow rates, outer pipe diameter, grout, and depths between 1 and 4 km. A finite-element framework models the Navier–Stokes fluid flow and heat transfer in the CDBHE system, validated with a field test on CDBHE from the literature. Results show that a 4-km CDBHE could produce a thermal power of 600 kW under the optimum geological conditions at the UCSD site: the water flow rate of 2.78 L/s and a ground thermal gradient of 60 ℃/km. Thermal power shares from different layers indicate that deeper formation layers contribute more to the thermal power than the shallower layers because increasing the CDBHE length from 1 to 4 km can lead to a maximum of 900% increase in thermal power and a 50% expansion in thermal plume for a CDBHE with an insulated inner pipe between the upper and lower bound heat flow bounds. An inner pipe with an insulated depth of 2 km produces only 1–6% less power than a fully insulated inner pipe for the 4-km CDBHE, and thus, a partially insulated vacuum-insulated tube (VIT)-plastic inner pipe is suggested as the best practice. Furthermore, the CDBHE thermal power increases by 5% when the grout thermal conductivity increases from 1 to 3.65 W/(K∙m), close to the formation thermal conductivity, and then maintains almost the same, and the 4-km CDBHE with flow rates of 2.78–6.94 L/s at the UCSD site can directly supply a low-temperature heating radiator system for room heating. This study suggests practical ranges for geothermal energy extraction for southern California. A CDBHE with a well-insulated inner pipe of 0.05 W/(m∙K), the thermal power of lower and upper-bound heat flow cases can vary by 60% from the mean. Finally, water as the working fluid is more efficient than CO2, doubling CDBHE's thermal power. The effects of the investigated factors provide guidelines for future geothermal resource exploitation in southern California.
Gabapentin and pregabalin exposures reported to United States poison centers, 2012–2022
Authors: Carter Emily J.R. , Rine Natalie I. , Kistamgari Sandhya , Hays Hannah L. , Spiller Henry A. , Yang Jingzhen , Zhu Motao , Smith Gary A. 
Published: November 2024

Abstract
Background
Gabapentin and pregabalin were originally introduced as anticonvulsant medications but are now also prescribed on- and off-label for multiple medical disorders, especially for pain management. The national opioid crisis has led to increased use of non-opioid pain medications, including gabapentinoids, which has been associated with changing patterns of adverse events associated with these medications. This study investigated the characteristics and trends of gabapentin and pregabalin exposures reported to US poison centers from 2012 to 2022.

Methods
National Poison Data System data involving gabapentin and pregabalin exposures for 2012 to 2022 were analyzed.

Results
There were 124,161 exposures involving gabapentin and pregabalin as the primary substance reported to US poison centers during the study period. Most exposures involved gabapentin (85.9%), females (59.4%), single-substance exposures (62.9%), or occurred at a residence (97.2%). Suspected suicides accounted for 45.2% of exposures. Most exposures were associated with a minor effect (27.4%) or no effect (34.0%), while 22.1% experienced a serious medical outcome, including 96 fatalities. The rate of gabapentin and pregabalin exposures per one million US population increased by 236.1% from 22.7 in 2012 to 76.5 in 2019 (P < 0.001), followed by a non-significant decrease to 68.5 in 2022 (P = 0.068).

Conclusions
The rate of gabapentin and pregabalin exposures reported to US poison centers increased by more than 230% from 2012 to 2019 before plateauing from 2019 to 2022. The observed rate trend was driven primarily by gabapentin exposures and by cases associated with suspected suicide. Although most exposures were associated with a minor or no effect, 22% of individuals experienced a serious medical outcome, including 96 fatalities. These findings contribute to the discussion of rescheduling gabapentin as a federally controlled substance, which is the current status of pregabalin. Prevention of suicide associated with gabapentin and pregabalin merits special attention.
Successful laparoscopic arterial ligation of splenic artery aneurysm with a splenomesenteric trunk: a case report and literature review
Authors: Takeo Shigeya , Izumi Hideki , Yoshii Hisamichi , Fjino Rika , Mukai Masaya , Furuya Hidekazu , Yamamoto Akiyoshi , Kamei Shunsuke , Ogawa Yukihisa , Hasebe Terumitsu , Kaneko Junichi , Makuuchi Hiroyasu 
Published: November 2024

Abstract
Background
The mortality rate of splenic artery aneurysm rupture is very high, and patients with aneurysms larger than 30 mm are recommended for treatment, regardless of the presence or absence of symptoms. We herein report a case of splenic artery aneurysm with an abnormal bifurcation that was treated with laparoscopic ligation of the splenic artery.

Case presentation
A 51 year-old Japanese male was referred to our hospital because a splenic artery aneurysm was noted on abdominal echocardiography during a medical examination. The splenic artery bifurcated from the superior mesenteric artery (SMA), and a 38-mm splenic artery aneurysm was found just after the bifurcation; thus, surgery was performed. Intraoperative angiography was performed, a balloon catheter was placed before the splenic artery bifurcation, and laparoscopic splenic artery ligation was performed to prepare for sudden bleeding. After ligation of the splenic artery, angiography was performed again to confirm the absence of the splenic artery aneurysm and that the peripheral splenic artery was visible through the peripheral collateral vessels. The patient was discharged on the fourth postoperative day, with good progress. Contrast-enhanced computed tomography performed 1 month postoperatively confirmed the disappearance of the splenic artery aneurysm, and the contrast-enhanced peripheral splenic artery was visible.

Conclusion
This is the first report of a safe laparoscopic artery ligation procedure for a splenic artery aneurysm with an abnormal splenic artery bifurcation from the SMA, in which a balloon catheter was placed at the splenic artery bifurcation.
Cost-effectiveness of strengthening blood pressure classification in South Korea: comparing the 2017 ACC/AHA and KSH guidelines
Authors: Kim KyungYi , Hong Min Ji , Kim Bomgyeol , Lee Hae-Young , Kim Tae Hyun 
Published: November 2024

Abstract
Background
Hypertension is a significant risk factor for cardiovascular disease (CVD), with hypertension-related deaths increasing annually. While South Korea uses the Korean Society of Hypertension (KSH) guideline of 140/90 mmHg, the American College of Cardiology (ACC) and American Heart Association (AHA) updated their guidelines in 2017 to 130/80 mmHg. This study evaluates the cost-effectiveness of transitioning to the 2017 ACC/AHA guidelines by estimating early treatment impacts and potential CVD risk reduction.

Methods
A Markov state-transition simulation model with a 10-year horizon was used to estimate cost-effectiveness, focusing on strengthening target blood pressure. Quality-adjusted life years (QALYs) served as the measure of effectiveness. Cohorts of 10,000 individuals representing South Koreans in their 20s through 80s were compared in scenario analyses from the healthcare system perspective. A 4.5% annual discount rate was applied to costs and effectiveness. Primary outcomes were incremental cost-effectiveness ratio (ICER) and net monetary benefit (NMB). The willingness-to-pay (WTP) threshold was < KRW 30,000,000/QALY gained. Probabilistic sensitivity analyses (PSAs) addressed model input parameter uncertainties.

Results
The base-case analysis showed an ICER value of KRW 1,328,395/QALY gained across all populations. ICER values increased with age, from − KRW 3,138,071/QALY for 20-year-olds to KRW 16,613,013/QALY for individuals over 80. The 60s age group showed the greatest benefit with an incremental QALY gain of 0.46. All scenarios had ICERs below the WTP threshold, with a PSA probability of 98.0% that strengthening blood pressure classification could be cost-effective.

Conclusions
This economic evaluation found that adopting the 2017 ACC/AHA guidelines may result in early treatment, reduce the potential incidence of CVD events, and be cost-effective across all age groups. The study findings have implications for policymakers deciding whether and when to revise official guidelines regarding target blood pressure levels, considering the impacts on public health and budgetary concerns.
Bridging the gap: challenges of urban planning and policies for favelas in Salvador, Brazil
Authors: Zhang Yixuan 
Published: November 2024

AbstractSalvador, the capital of Bahia State in Brazil, has long struggled with pronounced economic and social inequality. This stratification has resulted in spatial segregation, leading to the expansion of favelas, typically near the city center, where segregation in various dimensions of social engagement intensifies tensions of inequities. The municipal government has made several attempts to address favela-related issues through urban planning policies. Notwithstanding the progress made in lowering violent crime and extreme poverty, these issues still exist. This paper explores the interaction between government-led practices and corresponding self-organized actions toward planning strategies, invoking a social justice framework and critical urban theories. It identifies mismatches between institutional objectives and residents’ expectations, highlighting that structural contradictions in the region’s social development remain unresolved. The analysis suggests that planning policies should consider key factors, such as resource redistribution, recognition of sociocultural identity, and political representation. On the basis of these findings, this paper offers insights into urban planning for favelas as examples of complex governance challenges. It also aims to contribute to the global discourse on similar urban planning issues.
Analysis of the causal relationship between immune cells and rheumatoid arthritis from the perspective of genetic variation: a bidirectional two-sample Mendelian randomization study
Authors: Cheng Feng , Zhu YingJia , Liu XiaoQian , Zhang RuiKun , Xia Fei , Ge LinPu 
Published: November 2024

Abstract
Background
Immune factors are crucial in the pathogenesis of rheumatoid arthritis (RA), and immune cells play a key role in the development of RA. However, there is still disagreement regarding the specific roles of each type of immune cell in the pathological process of RA.

Methods
This study used bidirectional two-sample Mendelian randomization (MR) analysis to determine the causal relationship between immune cell characteristics and RA. Utilizing publicly available genetic data, we initially treated immune cell characteristics as exposures to investigate their causal effects on the risk of RA. Subsequently, we performed reverse two-sample MR using the positively selected cells from the initial analysis as outcomes, aiming to identify the core immune cells involved. Finally, a comprehensive sensitivity analysis was conducted to validate the robustness, heterogeneity, and horizontal pleiotropy of the results.

Results
Using data from 731 immune cells as exposures and cell SNPs as instruments, we independently conducted two-sample MR analysis for each patient with RA. The main analytical method used was the IVW method, with a significance level set at P < 0.05 for inclusion. In total, we identified 42 immune cell phenotypes that were causally associated with the onset of RA. For the reverse MR analysis, we used RA as the exposure factor and focused on 42 immune cell phenotypes as outcomes. Our analysis revealed causal relationships between the onset of RA and 7 immune cell phenotypes. Among these, 6 showed positive causal relationships, while 1 exhibited a negative causal relationship.

Conclusions
Our study emphasized the causal relationship between immune cells and RA through bidirectional two-sample MR analysis, identifying the immune cells causally associated with RA.
A large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging
Authors: Mok Aaron T. , Wang Tianyu , Zhao Shitong , Kolkman Kristine E. , Wu Danni , Ouzounov Dimitre G. , Seo Changwoo , Wu Chunyan , Fetcho Joseph R. , Xu Chris 
Published: November 2024

AbstractIn vivo imaging of large-scale neuronal activity plays a pivotal role in unraveling the function of the brain's circuitry. Multiphoton microscopy, a powerful tool for deep-tissue imaging, has received sustained interest in advancing its speed, field of view and imaging depth. However, to avoid thermal damage in scattering biological tissue, field of view decreases exponentially as imaging depth increases. We present a suite of innovations to optimize three-photon microscopy for large field-of-view imaging at depths unreachable by two-photon microscopy. These techniques enable us to image neuronal activities of transgenic animals expressing protein calcium sensors in a ~ 3.5-mm diameter field-of-view with single-cell resolution in the deepest cortical layer of mouse brains. We further demonstrate simultaneous large field-of-view two-photon and three-photon imaging, subcortical imaging in the mouse brain, and whole-brain imaging in adult zebrafish. The demonstrated techniques can be integrated into typical multiphoton microscopes to enlarge field of view for system-level neural circuit research.
According to the Record
Authors: Wright Lisa E. 
Published: November 2024

Abstract
In this piece Lisa E. Wright analyzes the penmanship on her grandmother’s birth certificate to question whether her great-grandmother gave birth to her Grandma Rickey in 1934 with a white doctor or with a midwife who may not have had a license. She explores if her grandmother’s birth reflected changing attitudes toward Black midwives, her great-grandmother’s choice, or a luxury afforded to her great-grandmother by her great-grandfather’s status as a Black coal miner. To analyze the decisions of the next generation of women who gave birth in her family, in this piece Wright struggles with the reasons her grandmother looked outside their community of midwives for maternal care and gave birth in a Jim Crow hospital in Lynchburg, Virginia.
Consumption as Changemaking and Producers as Artists
Authors: Chakravarty Debjani , Standish Christine 
Published: November 2024

Abstract
In this article the authors perform a transnational feminist analysis of marketing strategies deployed in compassionate consumption. This strategy communicates to the consumer that consuming equals doing good. Using public-facing website data, the authors conduct a discourse analysis of alt-profit corporations, a term they coined to demonstrate yet another widespread strategy of late capitalism. Applying a transnational feminist perspective, they postulate that these alt-profits (meant to invoke “alternative” and “altruistic” actions by corporations) McDonaldize their marketing strategies to capitalize on consumer interests for sustainability, fair trade, “women’s empowerment,” and a desire to consume artisanal goods. They further argue that artisans from the Global South serving consumers in the Global North are framed as gendered and globalized in a way that helps sales. This is done purposefully using text and graphics, including digital storytelling, buzzwords, and vibrant photography. Contrary to the Marxist framework of alienation, artisans are presented as workers who find joy in their work. Alt-profits invite consumers to buy products and appreciate the unique experience of “meeting the artists.” The authors conclude that the formulaic pattern of communication used by alt-profits is both distinct to them yet also common in publicizing any compassionate consumption and ultimately negates the reality of current global markets necessitating exploitative capitalist structures such as opaque and unsustainable supply chains.