bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose‐6‐phosphate dehydrogenase mutant D306C has a higher inhibition rate for enzyme multiplied immunoassay of cholyglycine
Authors: Qi Jinxiang , Xiao Lanping , Zhang QiFei , Feng Jianxin , Wang Guili , Gong Jun 
Published: May 2019

AbstractGlucose‐6‐phosphate dehydrogenase (G6PDH) has been used in enzyme multiplied immunoassay technique (EMIT) assays for detecting small molecule metabolites such as cholyglycine (CG). A key parameter for successful EMIT CG assay development is the inhibition rate of the G6PDH–CG conjugate, measured as the decrease in enzyme activity upon CG antibody binding. Several commonly used G6PDH cysteine mutants including A45C and K55C have been labeled with CG‐maleimide derivative, but inhibition rates of are unsatisfactory. Herein, we investigated whether other mutation sites can achieve better inhibition rates. We generated eight cysteine mutants (K106C, Y155C, A201C, T258C, D306C, D375C, G426C, and D480C) of G6PDH, measured their inhibition rates, and evaluated the performance of the D306C mutant using EMIT CG assays. One of the eight mutants (D306C) displayed improved inhibition rate, whereas all others exhibited inhibition similar to or lower than that of A45C and K55C. The enhanced inhibition rate of D306C improved the EMIT CG assay calibration curve, using an Abbott c16000 automated biochemical analyzer, resulting in better repeatability, precision, and linearity than with K55C assays and a commercially available EMIT CG kit. The G6PDH mutant D306C has a higher inhibition rate in EMIT CG assays and improves assay performance.
Neuer Ansatz der thermischen Leitfähigkeit von Beton für die Brandschutzbemessung in Eurocode 2
Authors: Spille Jens , Zehfuß Jochen 
Published: May 2019

AbstractDie Brandschutzbemessung von Betonbauteilen unter Anwendung des „heißen“ Eurocode 2 mithilfe numerischer Berechnungen findet immer mehr Einzug in die Praxis. Ein wesentlicher Bestandteil einer solchen Bemessung besteht aus der Ermittlung der Querschnittstemperaturen der Bauteile unter transienter Brandbeanspruchung. Zur Ermittlung dieser Temperaturen beinhaltet die DIN EN 1992‐1‐2 temperaturabhängige Verläufe für die thermische Leitfähigkeit von Beton. Der nationale Anhang der DIN EN 1992‐1‐2 regelt für Deutschland, dass bei der Bemessung die sogenannte obere Grenzwertfunktion der thermischen Leitfähigkeit anzuwenden ist.Thermische Analysen unter Ansatz dieser Grenzwertfunktion haben jedoch gezeigt, dass bei der Bewertung des Raumabschlusskriteriums von beflammten Bauteilen zu konservative Ergebnisse erzielt werden, die nicht mit den tabellierten Mindestdicken nach Abschnitt 5 DIN EN 1992‐1‐2, für die das Raumabschlusskriterium als eingehalten gilt, übereinstimmen. In diesem Beitrag wird ein neuer Ansatz für die thermische Leitfähigkeit von Beton vorgestellt, der anhand von numerischen Vergleichsrechnungen zu ausgewählten experimentell bestimmten Temperatur‐Zeitkurven überprüft wurde. Hierzu wurden 15 Versuche an Wand‐, Decken‐ und Stützenprüfkörpern herangezogen, die am Institut für Baustoffe, Massivbau und Brandschutz (iBMB) der TU Braunschweig und im europäischen Ausland durchgeführt wurden.
Green‐Emitting Rhodamine Dyes for Vital Labeling of Cell Organelles Using STED Super‐Resolution Microscopy
Authors: Grimm Florian , Nizamov Shamil , Belov Vladimir N. 
Published: May 2019

AbstractFluorescence microscopy reveals the localization, spatial distribution, and temporal dynamics of the specifically labeled organelles in living cells. Labeling with exogenous conjugates prepared from fluorescent dyes and small molecules (ligands) is an attractive alternative to the use of fluorescent proteins, but proved to be challenging due to insufficient cell‐permeability of the probes, unspecific staining, or low dye brightness. We evaluated four green‐emitting rhodamine dyes and their conjugates intended for the specific labeling of lysosomes, mitochondria, tubulin, and actin in living cells. The imaging performance of the probes in living human fibroblasts has been studied by using confocal and stimulated emission depletion (STED) super‐resolution microscopy with a commercial 595 nm STED laser. Two bright and photostable dyes (LIVE 510 and LIVE 515) provide specific and versatile staining.
The utilization of vascularized pedicle combination epithelial‐sub epithelial tissue graft for socket preservation in the esthetic zone—A novel approach
Authors: Al Rezk Feras , Al Rezk Mania , Al Rezk Mohanad , Al Rezk Rami 
Published: May 2019

AbstractThe vascularized tunneled combine epithelialize‐subepithelialize connective tissue graft may yield biological outcomes superior to those achieved separately by rotated vascularization or combination interposition onlay tissue graft. This technique may provide clinicians with pathway to improve socket seal by improving the vascularity and the volume of the tissue seal, which would be paramount for the definitive esthetic and functional outcome for modern demand of our patients.
Catalytic Asymmetric γ‐Lactam Synthesis from Enolisable Anhydrides and Imines
Authors: Collar Aarón Gutiérrez , Trujillo Cristina , Lockett‐Walters Bruce , Twamley Brendan , Connon Stephen J. 
Published: May 2019

AbstractAn anion‐binding approach to the problem of preparing enantioenriched γ‐lactams from enolisable anhydrides and imines is reported. A simple bisurea catalyst promotes the cycloaddition between α‐aryl succinic anhydrides and either PMP‐ or benzhydryl‐protected aldimines to provide γ‐lactams with two contiguous stereocentres (one quaternary) with complete diastereocontrol and high to excellent enantioselectivity for the first time. A DFT study has provided insight into the catalyst mode of action and the origins of the observed stereocontrol.
Aus weniger mehr machen
Authors: Saulich Katja 
Published: May 2019

AbstractProzessintensivierte Verfahren in der chemischen Industrie bergen ein hohes Ressourceneffizienzpotenzial, da sie dazu beitragen, Materialien und Energie einzusparen. In den 1970er Jahren kam die Idee auf, mittels Prozessintensivierung die Entwicklung bahnbrechender Technologien anzustoßen. Was sich seit damals bis heute getan hat, hat das VDI Zentrum Ressourceneffizienz (VDI ZRE) in einer jetzt erschienenen Kurzanalyse zusammengefasst.
Schon viel bewegt ‐ noch viel zu tun
Authors: Sieß Wolfgang 
Published: May 2019

Abstract„Nicht sehr zufrieden“ ist der seit vergangenem Jahr amtierende Vorstand des Frankenthaler Pumpen‐ und Armaturenherstellers KSB mit dem Ergebnis des abgelaufenen Geschäftsjahres, denn der Gewinn sank, obwohl der Umsatz gestiegen ist. Man habe aber „bereits viel bewegt“ und damit begonnen, den „schlafenden Riesen behutsam zu wecken“, so der Geschäftsführende Direktor und Sprecher der Geschäftsleitung Dr. Stephan Timmermann bei Vorstellung der Bilanz für das Jahr 2018.
Aus Ereignissen lernen und Innovationen leben
Authors: Woppowa Ljuba 
Published: May 2019

AbstractEtwa 70 Berufseinsteiger kamen zum 4. Jahrestreffen der Young Professionals in der chemischen Industrie nach Dortmund, um sich im Rahmen des Messeduos Maintenance und Pumps&Valves auszutauschen. Das Motto der von der VDI‐Gesellschaft Verfahrenstechnik und Chemieingenieurwesen (VDI‐GVC) organisierten Veranstaltung lautete: Aus Ereignissen lernen, Wissen teilen, Innovationen leben. Neben den Vorträgen boten die geführten Messerundgänge zudem einen wichtigen Praxisbezug für die Teilnehmer. Das 5. Jahrestreffen der Young Professionals wird am 12.02.2020 erneut in Dortmund parallel zu den beiden Messen stattfinden.
Mahlsieb mit gezackten Klingen
Authors:   Kason Corporation
Published: May 2019

AbstractAgglomerate bis zu einer Größe von 250 mm kann der neue Kason Klumpenbrecher, Modell LB 550, in Partikel mit einer durchschnittlichen Größe von bis zu 2 mm reduzieren. Bei minimaler Wärmeentwicklung und Feinstaubbildung erlaubt der Klumpenbrecher einen Durchsatz von 2 bis 25 t/h.
Wärmegetriebene Motoren
Authors: Glouchenkov Maxim , Kronberg Alexander , Kenig Eugeny , Mügge Nils 
Published: May 2019

AbstractEncontech, ein Spin‐Off‐Unternehmen der Universität Twente (Enschede, Niederlande), hat in Kooperation mit der Universität Paderborn eine neuartige Wärmekraftmaschine mit vielseitigen Anwendungsbereichen entwickelt. Der Motor wandelt Wärme direkt in mechanische Arbeit um und eignet sich im besonderen Maße für den Einsatz als Kompressor oder Pumpe. Durch die Bauart lässt sich jegliche Form der zur Verfügung stehenden Wärme ab einem Temperaturniveau von 60°C nutzen. Mit diesen Eigenschaften ist der neuentwickelte Motor eine simple und ökonomische Alternative zu heutigen elektrisch angetriebenen Kompressoren und Pumpen im Megawatt‐Leistungsbereich.
Nahtlos im Gesamtverbund
Authors: Meißler Sebastian 
Published: May 2019

AbstractWenn die Kombination aus dem Standardbaukasten nicht richtig passt, dann ist der Maßanzug gefragt. Bei AERZEN sind es individuell konzipierte Druckluftlösungen, die im Mittelpunkt des Auftritss bei der Comvac standen. Ein in Hannover gezeigtes Beispiel für die Spezialisierung aus dem Produktstandard heraus sind die zweistufigen AERZEN‐Verdichter der Baureihe 2C mit ihrer hohen funktionalen Anpassungsfähigkeit auch für unterschiedliche Antriebs‐ und Steuerungskonzepte.
Trockenschrauber
Authors: Angenendt Christoph 
Published: May 2019

AbstractDie Division Industrial Vacuum von Atlas Copco bringt mit der DHS 065‐200 VSD+ eine neue Trockenschrauben‐Vakuumpumpe auf den Markt. Die Pumpe bietet Anwendern vor allem niedrigere Lebenszykluskosten, höhere Produktivität, einen geringen Energieverbrauch sowie einfache Wartungsmöglichkeiten.
Druckluftaufbereitung ohne Kompromisse
Authors: Strack Norbert 
Published: May 2019

Abstract„Druckluftaufbereitung ohne Kompromisse“ versprach Beko Technologies den Besuchern der ComVac in Hannover. Das Neusser Unternehmen legt einen Schwerpunkt auf individuelle Anforderungen und Bedürfnisse von Produzenten unterschiedlicher Branchen. „Mit flexiblen Lösungen sorgen wir dafür, dass diese immer mit der für ihren Prozess passenden Druckluftqualität arbeiten“, sagt Norbert Strack, einer der beiden Geschäftsführer.
Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams
Authors: Ellis Justin K. , Sorrells Shawn F. , Mikhailova Sasha , Chavali Manideep , Chang Sandra , Sabeur Khalida , Mcquillen Patrick , Rowitch David H. 
Published: May 2019

AbstractThe human early postnatal brain contains late migratory streams of immature interneurons that are directed to cortex and other focal brain regions. However, such migration is not observed in rodent brain, and whether other small animal models capture this aspect of human brain development is unclear. Here, we investigated whether the gyrencephalic ferret cortex possesses human‐equivalent postnatal streams of doublecortin positive (DCX+) young neurons. We mapped DCX+ cells in the brains of ferrets at P20 (analogous to human term gestation), P40, P65, and P90. In addition to the rostral migratory stream, we identified three populations of young neurons with migratory morphology at P20 oriented toward: (a) prefrontal cortex, (b) dorsal posterior sigmoid gyrus, and (c) occipital lobe. These three neuronal collections were all present at P20 and became extinguished by P90 (equivalent to human postnatal age 2 years). DCX+ cells in such collections all expressed GAD67, identifying them as interneurons, and they variously expressed the subtype markers SP8 and secretagogin (SCGN). SCGN+ interneurons appeared in thick sections to be oriented from white matter toward multiple cortical regions, and persistent SCGN‐expressing cells were observed in cortex. These findings indicate that ferret is a suitable animal model to study the human‐relevant process of late postnatal cortical interneuron integration into multiple regions of cortex.
An intelligent trust model for hybrid DDoS detection in software defined networks
Authors: Gong Changqing , Yu Delong , Zhao Liang , Li Xiguang , Li Xianwei 
Published: May 2019

SummarySoftware Defined Networks (SDNs) have been extensively studied in recent years. The centralised and programmable controller also brings many security challenges. As a conventional attack with the purpose of destruction, Distributed Denial of Service (DDoS) is still a threat for Software Defined Networks (SDNs). There is a lack of trust evaluation and management mechanism between the OpenFlow switches in SDNs. Therefore, in this paper, we propose a trust evaluation and management model, namely, the Intelligent Trust Model (ITM). In this framework, the Extreme Learning Machine (ELM) is applied to detect hybrid DDoS in Software Definition Networks (SDNs). Our model (ITM) can update the trust value of the OpenFlow switches in real time and respond quickly to different types of DDoS attacks. Compared with others, the experiment results show that our model can provide more efficient detection with high detection accuracy and low false positive rate for the hybrid DDoS attack. At last, in our proposal, OpenFlow switches with higher trust have a relatively higher priority. Therefore, we solve the flow conflict issue in the infrastructure layer.
A study on the evaluation of HPC microservices in containerized environment
Authors: Jha Devki Nandan , Garg Saurabh , Jayaraman Prem Prakash , Buyya Rajkumar , Li Zheng , Morgan Graham , Ranjan Rajiv 
Published: May 2019

SummaryContainers are gaining popularity over virtual machines as they provide the advantages of virtualization with the performance of near bare metal. The uniformity of support provided by Docker containers across different cloud providers makes them a popular choice for developers. Evolution of microservice architecture allows complex applications to be structured into independent modular components making them easier to manage. High‐performance computing (HPC) applications are one such application to be deployed as microservices, placing significant resource requirements on the container framework. However, there is a possibility of interference between different microservices hosted within the same container (intracontainer) and different containers (intercontainer) on the same physical host. In this paper, we describe an extensive experimental investigation to determine the performance evaluation of Docker containers executing heterogeneous HPC microservices. We are particularly concerned with how intracontainer and intercontainer interference influences the performance. Moreover, we investigate the performance variations in Docker containers when control groups (cgroups) are used for resource limitation. For ease of presentation and reproducibility, we use Cloud Evaluation Experiment Methodology (CEEM) to conduct our comprehensive set of experiments. We expect that the results of evaluation can be used in understanding the behavior of HPC microservices in the interfering containerized environment.
Understanding Aggregation Induced Emission in a Propeller‐Shaped Blue Emitter
Authors: Stojanović Ljiljana , Crespo‐Otero Rachel 
Published: May 2019

AbstractOrganic fluorophores with an enhanced emission in the condensed phase have great potential for the design of optoelectronic materials. Several propeller‐shaped molecules show aggregation‐induced emission (AIE), in particular, silole derivatives have attracted wide attention because of their significant quantum yields in the solid state. In this contribution, we investigate the mechanism of AIE of a propeller‐shaped blue emitter: 1,2,3,4‐tetraphenyl‐1,3‐cyclopentadiene (TPC). We explore the excited state mechanism in the light of models most commonly used to explain it: restriction of intramolecular motions (RIM) and restricted access to the conical intersection (RACI). Our interpretation is supported by excited state dynamics simulations and the analysis of Huang‐Rhys factors and reorganisation energies. We quantify the effects of intermolecular interactions and exciton couplings. The mechanism for TPC is compared with previous investigations of analogue silole compounds. Our systematic investigation highlights the role of conical intersections on the nonradiative decay mechanisms and complementary descriptions provided by the RIM and RACI models.
Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane‐1,2,5‐triol from Furfuryl Alcohol
Authors: Simeonov Svilen P. , Ravutsov Martin A. , Mihovilovic Marko D. 
Published: May 2019

AbstractA new scalable synthesis of pentane‐1,2,5‐triol from the furanics platform has been developed. Excellent yields of up to 92 % are obtained under flow conditions by using readily available catalysts from the existing pool. The strategy exploits the highly functionalized Achmatowicz product as a key intermediate, thus circumventing problems related to the low reactivity of the parent furfural and furfuryl alcohol. Besides expanding the portfolio of biomass‐derived C5 alcohols, this strategy may also be further applied for the establishment of a versatile bio‐based chemical platform.
Enhancing Visible‐Light Hydrogen Evolution Performance of Crystalline Carbon Nitride by Defect Engineering
Authors: Ren Wei , Cheng Jiajia , Ou Honghui , Huang Caijin , Titirici Maria‐Magdalena , Wang Xinchen 
Published: May 2019

AbstractCrystalline carbon nitride (CCN)‐based semiconductors have recently attracted widespread attention in solar energy conversion. However, further modifying the photocatalytic ability of CCN always results in a trade‐off between high crystallinity and good photocatalytic performance. Herein, a facile defect engineering strategy was demonstrated to modify the CCN photocatalysts. Results confirmed that the obtained D‐CCN maintained the high crystallinity; additionally, the hydrogen production rate of D‐CCN was approximately 8 times higher than that of CCN. Particularly, it could produce H2 even if the incident light wavelength extended to 610 nm. The significantly improved photocatalytic activity could be ascribed to the introduction of defects into the CCN polymer network to form the midgap states, which significantly broadened the visible‐light absorption range and accelerated the charge separation for photoredox catalysis.
Invertebrate biodiversity in cold groundwater fissures in Iceland
Authors: Ólafsdóttir Jónína H. , Þorbjörnsson Jóhann G. , Kristjánsson Bjarni K. , Ólafsson Jón S. 
Published: May 2019

AbstractIceland has an abundance of fissures that are parallel to the Mid‐Atlantic Ridge where bedrock cracks as a result of continental rifting. Some fissures penetrate the aquifer and expose the groundwater within the bedrock, becoming springs. As such, groundwater fissures have uniform and constant physical and chemical environment but they can differ greatly in morphology. In addition, there is often great variation in depth within fissures and substrate types contrast between vertical rock wall and more heterogenous horizontal bottom. The variation in morphological environment may create dissimilar habitats with unique characteristics and/or influence distribution of resources. Our objective was to study macrozoobenthos communities in cold groundwater fissures in Iceland in relation to physical habitat by comparing invertebrate diversity and density both between fissures with different morphological characteristics as well as between substrate types and depths within fissures. Samples were collected in two fissures in SW Iceland, Silfra and Flosagjá. Assemblages were similar between fissures except for higher densities of cladocerans in Flosagjá fissure. Within fissures, there was significant difference in Shannon diversity between substrate types in Flosagjá, and ostracods were found in significantly higher densities on the bottom. The distribution of all other taxa groups was homogenous in both fissures regardless of depth gradient and substrate. Invertebrates were found to be living within and around a biofilm that covered the entire substrate. These biofilm mats are made from Cyanobacteria and benthic diatoms, which are successful under low light conditions and may minimize any effect of the heterogeneous habitat creating a uniform and suitable microhabitat for invertebrates regardless of depth and substrate type.
Intra‐annual variation and landscape composition interactively affect aphid community composition
Authors: Claflin Suzi B. , Hernandez Natalie , Groves Russell , Thaler Jennifer S. , Power Alison G. 
Published: May 2019

AbstractAgricultural intensification impacts local arthropod communities. The temporal and spatial variation of agricultural environments can have a significant impact on insect pest populations, yet little work has been done to date on the effect of intra‐annual variation (within season) or spatiotemporal effects on arthropod functional community composition. The aim of this research was to evaluate the effects of intra‐annual variation and landscape composition on the aphid community. To that end, we investigated the following research question: How do intra‐annual variation and landscape composition affect aphid abundance, species richness, and functional community composition? In this study, we quantified landscape composition as percent cropland, intra‐annual variation as sampling week measured throughout the growing season, and aphid functional community composition as crop virus transmission—or vectoring—ability. We collected data in two agricultural regions: a diversified agricultural region in New York State (NY) and an agriculturally intense potato‐growing region in Wisconsin (WI). We found that the interactive effect of landscape composition and intra‐annual variation significantly affected aphid abundance and species richness in both study regions, and functional community composition in NY. These results indicate that spatiotemporal shifts in agroecosystems have significant implications for aphid functional community composition.
A study on CSI feedback schemes exploiting feedforward information in FDD cellular systems
Authors: Zhang Xiaoyu , Centenaro Marco , Tomasin Stefano , Benvenuto Nevio , Luo Xiliang , Yang Shaoshi 
Published: May 2019

AbstractIn frequency‐division duplexing systems, the downlink (DL) channel is usually estimated at the user terminal (UT) and then fed back to the base station (BS) with a limited number of bits. In this paper, we exploit the partial dependency of the uplink (UL) and DL channels to design a new channel‐state information (CSI) reporting procedure that splits the signaling overhead between UL and DL. In particular, the DL channel quantization at the UT is adapted to the UL channel estimated at the BS. The BS estimates and quantizes the UL channel, and then sends to the UT the quantization index as feedforward signaling. This index is used in turn by the UT to select the quantization codebook for the DL channel. Finally, the BS reconstructs the DL channel by either using only the feedback from the UT or merging it with its unquantized knowledge of the UL channel. The number of feedforward and feedback bits is fixed, and the proposed approach balances the signaling overhead between UL and DL. For a given average number of total signaling bits, it turns out that a variable‐length feedback signaling avoids the use of feedforward, while still providing the minimum mean‐square‐error DL channel estimate at the BS. Numerical results prove the validity of proposed fix‐rate and variable‐rate solutions in the scenario of the COST 2100 model.