bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division
Authors: Iswahyudi  , Mukamolova Galina V. , Straatman-Iwanowska Anna A. , Allcock Natalie , Ajuh Paul , Turapov Obolbek , O’Hare Helen M. 
Published: June 2019

AbstractProtein phosphatase PstP is conserved throughout the Actinobacteria in a genetic locus related to cell wall synthesis and cell division. In many Actinobacteria it is the sole annotated serine threonine protein phosphatase to counter the activity of multiple serine threonine protein kinases. We used transcriptional knockdown, electron microscopy and comparative phosphoproteomics to investigate the putative dual functions of PstP as a specific regulator of cell division and as a global regulator of protein phosphorylation. Comparative phosphoproteomics in the early stages of PstP depletion showed hyperphosphorylation of protein kinases and their substrates, confirming PstP as a negative regulator of kinase activity and global serine and threonine phosphorylation. Analysis of the 838 phosphorylation sites that changed significantly, suggested that PstP may regulate diverse phosphoproteins, preferentially at phosphothreonine near acidic residues, near the protein termini, and within membrane associated proteins. Increased phosphorylation of the activation loop of protein kinase B (PknB) and of the essential PknB substrate CwlM offer possible explanations for the requirement for pstP for growth and for cell wall defects when PstP was depleted.
A systematic review of feasibility studies promoting the use of mobile technologies in clinical research
Authors: Bakker Jessie P. , Goldsack Jennifer C. , Clarke Michael , Coravos Andrea , Geoghegan Cynthia , Godfrey Alan , Heasley Matthew G. , Karlin Daniel R. , Manta Christine , Peterson Barry , Ramirez Ernesto , Sheth Nirav , Bruno Antonia , Bullis Emilia , Wareham Kirsten , Zimmerman Noah , Forrest Annemarie , Wood William A. 
Published: June 2019

AbstractMobile technologies, such as smart phone applications, wearables, ingestibles, and implantables, are increasingly used in clinical research to capture study endpoints. On behalf of the Clinical Trials Transformation Initiative, we aimed to conduct a systematic scoping review and compile a database summarizing pilot studies addressing mobile technology sensor performance, algorithm development, software performance, and/or operational feasibility, in order to provide a resource for guiding decisions about which technology is most suitable for a particular trial. Our systematic search identified 275 publications meeting inclusion criteria. From these papers, we extracted data including the medical condition, concept of interest captured by the mobile technology, outcomes captured by the digital measurement, and details regarding the sensors, algorithms, and study sample. Sixty-seven percent of the technologies identified were wearable sensors, with the remainder including tablets, smartphones, implanted sensors, and cameras. We noted substantial variability in terms of reporting completeness and terminology used. The data have been compiled into an online database maintained by the Clinical Trials Transformation Initiative that can be filtered and searched electronically, enabling a user to find information most relevant to their work. Our long-term goal is to maintain and update the online database, in order to promote standardization of methods and reporting, encourage collaboration, and avoid redundant studies, thereby contributing to the design and implementation of efficient, high-quality trials.
Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts
Authors: Yoshida Keisuke , Uchikoshi Eriko , Hara Satoshi , Hisabori Toru 
Published: June 2019

Abstract
Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol modulation by using hydrogen peroxide (H2O2) as an oxidizing force. This system plays a key role in switching chloroplast metabolism (e.g. Calvin–Benson cycle) during light to dark transitions; however, information on its function is still limited. In this study, we report a novel protein-activation mechanism based on the TrxL2/2CP redox cascade. Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative pentose phosphate pathway (OPPP). Biochemical studies, including redox state determination and measurement of enzyme activity, suggested that the TrxL2/2CP pathway is involved in the oxidative activation of G6PDH. It is thus likely that the TrxL2/2CP redox cascade shifts chloroplast metabolism to night mode by playing a dual role, namely, down-regulation of the Calvin–Benson cycle and up-regulation of OPPP. G6PDH was also directly oxidized and activated by H2O2, particularly when H2O2 concentration was elevated. Therefore, G6PDH is thought to be finely tuned by H2O2 levels in both direct and indirect manners.
The Speech-Language Pathologists' Role in Mild Traumatic Brain Injury for Early Childhood–, Preschool–, and Elementary School–Age Children: Viewpoints on Guidelines From the Centers for Disease Control and Prevention
Authors: Lundine Jennifer P. , Ciccia Angela H. , Brown Jessica 
Published: June 2019

Purpose
Traumatic brain injury (TBI) impacts millions of children each year, with those between birth and 4 years of age being 1 of the highest incidence groups. To address gaps in service provision specifically for children with mild TBI (mTBI), the Centers for Disease Control and Prevention (CDC) recently released guidelines for providers.

Method
The goal of this commentary is to deliver viewpoints on the application of the CDC guidelines directly to speech-language pathology clinical practice, with special attention paid to assessment, symptom monitoring, and intervention using a family-centered approach to care for infants, toddlers, preschoolers, and early elementary students with mTBI.

Results
In all pediatric practice settings, speech-language pathologists (SLPs) are a critical component of the care team for children who experience mTBI and should participate in symptom monitoring, assessment, intervention, education, and advocacy for this population.

Conclusions
SLPs can use the CDC guidelines to advocate for their role in the care of young children with mTBI. In addition, SLPs can use the guidelines to create a framework for clinical care provision when working with young children with mTBI. Much work is needed to advance evidence-based practices for this population, and dissemination of current clinical practices could help to close this gap.
Wideband compact planar balun for applications in outphasing and push–pull amplifiers
Authors: Bogusz A. , Lees J. , Quaglia R. , Watkins G.T. , Cripps S.C. 
Published: June 2019

This Letter presents a novel approach to realising and fabricating a planar balun structure, where conventional bond wires are replaced by conductor bridges supported on polyimide blocks. Three different prototype structures were fabricated on 10 mil thick alumina substrate (ɛr = 9.8, tan δ = 0.0001) using thin film fabrication technology. More than double octave bandwidths are reported, from 1.25 to 4.7 GHz with losses lower than 1 dB, an amplitude imbalance (trace separation) below 0.75 dB and phase imbalance within ±5°. Measurements show good agreement with simplified 2D EM simulations. The performance of the balun is assessed for suitability in applications where amplitude and phase balance are of critical importance, such as push–pull or outphasing amplifier topologies.
Matched NGD circuit with resistor‐connected coupled lines
Authors: Xiao Jian‐Kang , Wang Qiu‐Fen , Ma Jian‐Guo 
Published: June 2019

A negative group delay (NGD) circuit with simple structure has been proposed by using an open‐circuited resonator and a pair of short‐circuited coupled lines which are connected with two shunt resistors. The centre frequency of the NGD circuit is dominantly controlled by the open‐circuited resonator, while the shunt resistors connected coupled lines are utilised for port matching, which greatly attenuates S11 of the circuit. The proposed NGD circuit has been fabricated and measured, and the experiment shows an NGD time of − 4.6 ns, an NGD bandwidth of 120 MHz, and an S11 attenuation of >33 dB. The experimental results approach to the prediction.
Investigation of background noise in active distribution network and its impacts on synchrophasor estimation
Authors: Zhang Yong , Shi Zhixiong , Xue Jingrun 
Published: June 2019

The next‐future extensive diffusion of distributed generation and the increasing energy demands due to new components (e.g. electrical vehicles, energy storages) are changing the characteristics of the power grid at the distribution level, which makes it inevitable to introduce the synchrophasor measurement technology into the distribution network. This study analyses the power spectrum for the background noise of the field measured voltage signal of 0.4 kV in one electrical vehicle charging station. The coloured filter model is established using the autoregressive moving average process, which leads to the conclusion that the coloured noise spectrum is generally concave. The impact of background noise for the phasor estimation is evaluated in the steady state and dynamic state referring to IEEE Std C37.118.1™‐2011.
Characterizing maser polarization: effects of saturation, anisotropic pumping, and hyperfine structure
Authors: Lankhaar Boy , Vlemmings Wouter 
Published: June 2019

Context. The polarization of masers contains information on the magnetic field strength and direction of the regions they occur in. Many maser polarization observations have been performed over the last 30 years. However, versatile maser polarization models that can aide in the interpretation of these observations are not available.Aims. We developed a program suite that can compute the polarization by a magnetic field of any non-paramagnetic maser species at arbitrarily high maser saturation. Furthermore, we investigated the polarization of masers by non-Zeeman polarizing effects. We present a general interpretive structure for maser polarization observations.Methods. We expanded existing maser polarization theories of non-paramagnetic molecules and incorporated them in a numerical modeling program suite.Results. We present a modeling program called CHAracterizes Maser Polarization (CHAMP) that can examine the polarization of masers of arbitrarily high maser saturation and high angular momentum. Hyperfine multiplicity of the maser-transition can also be incorporated. The user is able to investigate non-Zeeman polarizing mechanisms such as anisotropic pumping and polarized incident seed radiation. We present an analysis of the polarization ofv = 1 SiO masers and the 22 GHz water maser. We comment on the underlying polarization mechanisms, and also investigate non-Zeeman effects.Conclusions. We identify the regimes where different polarizing mechanisms will be dominant and present the polarization characteristics of the SiO and water masers. From the results of our calculations, we identify markers to recognize alternative polarization mechanisms. We show that comparing randomly generated linear versus circular polarization (pL − pV) scatter-plots at fixed magnetic field strength to the observationally obtainedpL − pVscatter can be a promising method of ascertaining the average magnetic field strength of a large number of masers.
Ability to Propose Optimal Prosthetic Rehabilitation can be Improved by Discussion between the Dentist and Radiation Oncologist Regarding Upstream Dosimetry
Authors: Rouers Mélanie , Bornert Fabien , Truntzer Pierre , Dubourg Sarah , Bourrier Cyrielle , Antoni Delphine , Noël Georges 
Published: June 2019

Abstract
Objective Improvement of dental rehabilitation for patients who have undergone radiation therapy requires knowledge of the dose in the maxillary and mandible bones.
Materials and Methods Forty-three patients with head and neck cancers underwent evaluation for dental rehabilitation before radiation treatment dosimetry. The delivered dose to the maxilla and mandible was determined. From the dose data in the literature, three levels of risk of implant failure were defined. According to the delivered doses, the authors calculated the percentage of patients who could be fully rehabilitated with an implant, as proposed by the dentist before radiation planning.
Results Before dosimetry calculation, all of the completely edentulous arches and 94 partially edentulous (PESs) sextants could be optimally rehabilitated. After dose calculation, among the 14 arches of 7 patients who were completely edentulous, according to the mean and maximal delivered doses, 11 arches (78.6%) and 7 arches (50%) could receive an optimal prosthesis, respectively. For the three patients, who were PESs but with one arch that was completely edentulous, according to the mean and maximal delivered doses, one arch for each dose condition could receive an optimal prosthesis. Among the 94 PESs sextants, according to the mean and maximal delivered doses, 41 (43.6%) and 24 (25.5%) sextants could receive an optimal prosthesis, respectively.
Conclusion By determining the sites of implantation before dosimetry, the radiation oncologist could shield specified areas, potentially improving the possibilities for dental rehabilitation. The dialogue between the dentist and the radiation oncologist can improve the possibilities for implants and decrease the risk of unsafe implantation.
The Role of Low-Intensity Biostimulation Laser Therapy in Transforming Growth Factor β1, Bone Alkaline Phosphatase and Osteocalcin Expression during Orthodontic Tooth Movement in Cavia porcellus
Authors: Narmada Ida Bagus , Rubianto Muhammad , Putra Suhartono Taat 
Published: June 2019

Abstract
Objective The aim of this study is to analyze the low-intensity laser therapy (LILT) biostimulation mechanism as adjuvant therapy within orthodontic treatment as a means of accelerating bone remodeling by transforming growth factor β1 (TGF-β1), bone alkaline phosphatase (BALP), and osteocalcin (OSC) expression.
Materials and Methods An analytical experimental method incorporating a posttest only randomized the control group design. The sample consisted of 24 3- to 4-month-old male Cavia porcellus weighing between 300 and 500 g divided into three groups (group 1: control, group 2: received orthodontic treatment, and group 3: received orthodontic treatment with irradiation LILT). LILT biostimulation at a dose of 4 joule/cm2 was performed daily for 3 min on the mesial-distal labial-palatal of the first dextra and sinistra incisor for 2 weeks. The TGF-β1, BALP, and OSC expression was subjected to immunohistochemical analysis. An analysis of variance with multiple comparison, a Tukey's honestly significant difference test, a Kruskal–Wallis test, and a Wilcoxon–Mann–Whitney test were all performed (p < 0.05).
Results TGF-β1 expression was significantly different (p = 0.047; p < 0.05) in the tension area, but not in the compression side (p = 0.154; p > 0.05). BALP expression was significantly different in both the tension (p = 0.009) and compression areas (p = 0.005; p < 0.05). OSC expression was significantly different (p = 0.034; p < 0.05) in the tension side, but not in the compression area (p = 1.194; p > 0.05).
Conclusion LILT biostimulation can increase TGF-β1, BALP, and OSC expression during orthodontic tooth movement.
Top-Ten Tips for Imaging the Triangular Fibrocartilaginous Complex
Authors: Ng Alex W.H. , Tong Cina S.L. , Hung Esther H.Y. , Griffith James F. , Tse W.L , Wong Clara W.Y. , Mak Michael C.K. , Ho P.C 
Published: June 2019

AbstractThe triangular fibrocartilage complex (TFCC) is a crucial structure for both maintaining the stability of the distal radioulnar joint (DRUJ) and acting as a cushion for axial loading of the ulnocarpal joint. Injury to the TFCC can lead to early degeneration of the DRUJ and ulnocarpal joint, with resultant chronic wrist pain and weakness. The TFCC is a moderately complex structure with several attachments to the adjacent bony and cartilaginous structures. Familiarity with the anatomy of the TFCC is a prerequisite for identification of TFCC tears. Several pitfalls can occur while assessing the TFCC on magnetic resonance imaging (MRI) if one is not familiar with the MRI appearances. This article illustrates key tips for diagnosing TFCC tears on MRI.
Preference of Suture Specifications in a Selected Periodontal and Implant Surgeries in Turkey
Authors: Koyuncuoglu Cenker Zeki , Yaman Duygu , Kasnak Gokhan , Demirel Korkud 
Published: June 2019

Abstract
Objective Various suture materials and needles are now available for use in the dental surgery. The aim of this study was to determine the preference of suture materials among Turkish dentists by a dental survey.
Materials and Methods The survey was prepared and sent electronically to Turkish dentists through e-mail and/or Facebook. Dentists were asked to report their graduation year from dental school and their specialty if they have one. In addition, the type periodontal/implant operations and the frequency of those operations applied by them were questioned. The participants were to indicate their suture preferences for these procedures in a multiple-choice questionnaire.
Results Fifty-seven regular dentists, 49 periodontists, 22 oral surgeons, and 8 other specialists completed a self-administered survey. The majority of clinicians worked in private practice (77.9%). Nonabsorbable sutures were the most preferred for all procedures except periodontal plastic surgery. In regenerative surgeries, monofilament, 5–0 diameter suture material on a reverse cutting, 3/8 circle needle was preferred. In addition, for mucogingival surgery, 5–0 diameter suture material on a reverse cutting and 3/8 circle needle was favored. For dental implants, 4–0 diameter suture material on a reverse cutting and 3/8 circle needle was preferred. Monofilament and braided sutures were selected almost equally for implant operations.
Conclusions In periodontal and implant surgeries, dentists highly preferred the use of nonabsorbable sutures. In addition, the shape and diameter of needle had an important role in the selection of suture material. The present study's results may serve as a guide for the future studies.
Sedation During Neurocritical Care
Authors: Vanaclocha Nieves , Chisbert Vicente , Quilis Vicent , Bilotta Federico , Badenes Rafael 
Published: June 2019

AbstractSedation is an essential therapeutic strategy in the care of neurocritical patients. Intravenous sedative agents are the most widely used, with promising alternatives (dexmedetomidine, ketamine, and volatile agents) to propofol and midazolam arising. Studies designed to evaluate superiority and avoid biases are required. A neurological awakening test is safe in most patients. Potential risks and benefits of limiting deep sedation and daily interruption of sedation in these patients remain unclear. The aim of this review was to report recent clinical evidence on sedation in this subgroup of patients, focusing on its effects on clinical prognosis.
Repeated Peripheral Embolisms associated with Chronic Aortic Dissection
Authors: Aoyagi Shigeaki , Amako Mau , Wada Kumiko , Kosuga Tomokazu , Yasunaga Hiroshi 
Published: June 2019

AbstractA male patient developed acute type B aortic dissection (AD) extending to the right external iliac artery (EIA) and left common femoral artery at the age of 56 years. Two months after the diagnosis of AD, he developed right renal infarction suggesting embolism, as the right renal artery arose from a false lumen containing a mural thrombus. Seven years later, at the age of 63 years, the patient was readmitted for acute onset of intermittent claudication in the right leg. On admission, arterial pulses distal to the right femoral artery were absent. The right ankle-brachial pressure index (ABI) was 0.66, while the left ABI was 1.06. Computed tomography (CT) confirmed chronic type B AD and revealed a localized occlusion of the right EIA and disappearance of a small protruding thrombus in the false lumen that was found on the previous CT, suggesting a second embolism. Since recovery of antegrade blood flow was insufficient after catheter embolectomy, femorofemoral bypass was performed with resolution of ischemic symptoms. Postoperatively, the ABI recovered to 0.99 in the right and 1.12 in the left, and CT showed a patent bypass graft and restoration of blood flow to the right leg. This case indicates that embolism should be recognized as one of the possible causes of acute organ ischemia in patients with AD, even in patients with chronic AD.
Physician Burnout among Members of the Society for Maternal-Fetal Medicine
Authors: Hughes Francine , Francis Antonia P. , Sciscione Anthony C. 
Published: June 2019

AbstractObjective This study aimed to determine the rate of physician burnout among maternal-fetal medicine subspecialists and identify associated factors.Study Design Noninternational members of the Society for Maternal-Fetal Medicine (SMFM) were surveyed regarding burnout using a validated tool specifically designed for health professionals (Maslach Burnout Inventory—Human Services Survey). Burnout was defined as exceeding established cutoffs for emotional exhaustion or depersonalization. Demographic information and potential contributors associated with the presence of burnout were also examined.Results The survey was sent to 1,220 members and 44.1% of members completed the entire survey. The physician burnout rate was 56.5%. Factors associated with burnout included female gender, being 5 to 20 years in practice, self-perceived burnout, being somewhat or very dissatisfied with career or supervisor and charting for more than 4 hours per day. Factors associated with less burnout were being male, having some protected time for education and regular exercise. Women scored higher on emotional exhaustion and depersonalization and lower personal accomplishment compared with men.Conclusion Physician burnout among the SMFM members is higher than has been reported in other specialties. While some of these factors are modifiable, further study into why women have higher rates of burnout needs to be performed.
Anal Sphincter Injury Associated with Vaginal Twin Delivery
Authors: O'Leary Bobby D. , Bholah Tariq , Kalisse Tamara , Hehir Mark P. , Geary Michael P. 
Published: June 2019

Abstract
Objective Obstetric anal sphincter injury remains the most common cause of fecal incontinence in women, and research in twin pregnancies is sparse. This study aimed to examine risk factors for sphincter injury in twin deliveries over a 10-year period.
Study Design This was a retrospective study of twin vaginal deliveries in a tertiary-level hospital over 10 years. We examined the demographics of women who had a vaginal delivery of at least one twin. Logistic regression analysis was used to examine risk factors.
Results There were 1,783 (2.1%) twin pregnancies, of which 556 (31%) had a vaginal delivery of at least one twin. Sphincter injury occurred in 1.1% (6/556) women with twins compared with 2.9% (1720/59,944) singleton vaginal deliveries. Women with sphincter injury had more instrumental deliveries (83.3 vs. 27.6%; p = 0.008). On univariate analysis, only instrumental delivery was a significant risk factor (odds ratio: 2.93; p = 0.019).
Conclusion Sphincter injury occurs at a lower rate in vaginal twin pregnancies than in singletons. No twin-specific risk factors were identified. Discussion of the risk of sphincter injury should form part of patient counseling with regard to the mode of delivery.