bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive in-silico prediction of damage associated SNPs in Human Prolidase gene
Authors: Bhatnager Richa , Dang Amita S. 
Published: June 2018

AbstractProlidase is cytosolic manganese dependent exopeptidase responsible for the catabolism of imido di and tripeptides. Prolidase levels have been associated with a number of diseases such as bipolar disorder, erectile dysfunction and varied cancers. Single nucleotide polymorphism present in coding region of proteins (nsSNPs) has the potential to alter the primary structure as well as function of the protein. Hence, it becomes necessary to differentiate the potential harmful nsSNPs from the neutral ones. 19 nsSNPs were predicted as damaging by in-silico analysis of 298 nsSNPs retrieved from dbSNP database. Consurf analysis showed 18 out of 19 substitutions were present in the conserved regions. 4 substitutions (D276N, D287N, E412K, and G448R) that observed to have damaging effect are present in catalytic pocket. Four SNPs listed in splice site region were found to affect splicing of mRNA by altering acceptor site. On 3′UTR scan of 77 SNPs listed in SNP database, 9 SNPs were lead to alter miRNA target sites. These results provide a filtered data to explore the effect of uncharacterized nsSNP and SNP related to UTRs and splice site of prolidase to find their association with the disease susceptibility and to design the target dependent drugs for therapeutics.
The dynamic change of neutrophil to lymphocyte ratio can predict clinical outcome in stage I-III colon cancer
Authors: Li Zhigui , Zhao Rui , Cui Yaping , Zhou Yong , Wu Xiaoting 
Published: June 2018

AbstractWhether the dynamic change of neutrophil to lymphocyte ratio (delta-NLR) can predict the outcome in various malignancies remained controversial. The delta-NLR has not been evaluated in colon cancer. Thus, we conducted the study to evaluate the predictive value of the delta-NLR in patients with colon cancer who underwent curative resection. Three-hundred and fifty-four patients with stage I-III colon cancer were retrospectively analysed. Clinicopathological features, preoperative NLR and postoperative NLR were collected. Prognostic factors were evaluated by univariate and multivariate analysis. The one, three and five-year overall survival rate in the delta-NLR < 0 group was 98.2%, 90.7% and 83.6%, respectively; and in the delta-NLR ≥ 0 group was 98.4%, 96.9% and 95.3%, respectively (log-rank test, P = 0.002). Univariate and multivariate analysis showed that there was a strong relationship between delta-NLR and overall survival. In conclusion, the delta-NLR was an independent prognostic factor for overall survival in early stage colon cancer. Patients with increased delta-NLR had an favourable clinical outcome.
Migration of planets in circumbinary discs
Authors: Thun Daniel , Kley Wilhelm 
Published: June 2018

Aims. The discovery of planets in close orbits around binary stars raises questions about their formation. It is believed that these planets formed in the outer regions of the disc and then migrated through planet-disc interaction to their current location. Considering five different systems (Kepler-16, -34, -35, -38, and -413) we model planet migration through the disc, with special focus on the final orbital elements of the planets. We investigate how the final orbital parameters are influenced by the disc and planet masses.
Methods. Using two-dimensional, locally isothermal, and viscous hydrodynamical simulations, we first model the disc dynamics for all five systems, followed by a study of the migration properties of embedded planets with different masses. To strengthen our results, we apply two grid-based hydrodynamical codes using different numerics (PLUTO and FARGO3D).
Results. For all systems, we find that the discs become eccentric and precess slowly. We confirm the bifurcation feature in the precession period – gap-size diagram for different binary mass ratios. The Kepler-16, -35, -38, and -413 systems lie on the lower branch and Kepler-34 on the upper one. For systems with small binary eccentricity, we find a new non-monotonic, loop-like feature.
In all systems, the planets migrate to the inner edge of the disc cavity. Depending on the planet-disc mass ratio, we observe one of two different regimes. Massive planets can significantly alter the disc structure by compressing and circularising the inner cavity and they remain on nearly circular orbits. Lower-mass planets are strongly influenced by the disc, their eccentricity is excited to high values, and their orbits are aligned with the inner disc in a state of apsidal corotation.
In our simulations, the final locations of the planets are typically too large with respect to the observations because of the large inner gaps of the discs. The migrating planets in the most eccentric discs (around Kepler-34 and -413) show the largest final eccentricity in agreement with the observations.
CO envelope of the symbiotic star R Aquarii seen by ALMA
Authors: Ramstedt S. , Mohamed S. , Olander T. , Vlemmings W. H. T. , Khouri T. , Liljegren S. 
Published: June 2018

The symbiotic star R Aqr is part of a small sample of binary AGB stars observed with the Atacama Large Millimeter/submillimeter Array (ALMA). The sample stars are: R Aqr, Mira, W Aql, and π1 Gru. The sample covers a range in binary separation and wind properties, where R Aqr is the source with the smallest separation. The R Aqr binary pair consists of an M-type AGB star and a white dwarf at a separation of 45 mas, equivalent to about 10 AU at 218 pc. The aim of the ALMA study is to investigate the dependence of the wind shaping on the binary separation and to provide constraints for hydrodynamical binary interaction models. R Aqr is particularly interesting as the source with the smallest separation and a complex circumstellar environment that is strongly affected by the interaction between the two stars and by the high-energy radiation resulting from this interaction and from the hot white dwarf companion.
The CO(J = 3 →2) line emission has been observed with ALMA at ~0.5′′ spatial resolution. The CO envelope around the binary pair is marginally resolved, showing what appears to be a rather complex distribution. The outer radius of the CO emitting region is estimated from the data and found to be about a factor of 10 larger than previously thought. This implies an average mass-loss rate during the past ~100 yr of Ṁ ≈ 2×10−7 M⊙ yr−1, a factor of 45 less than previous estimates. The channel maps are presented and the molecular gas distribution is discussed and set into the context of what was previously known about the system from multiwavelength observations. Additional molecular line emission detected within the bandwidth covered by the ALMA observations is also presented.
Because of the limited extent of the emission, firm conclusions about the dynamical evolution of the system will have to wait for higher spatial resolution observations. However, the data presented here support the assumption that the mass-loss rate from the Mira star strongly varies and is focused on the orbital plane.
Disruptive Hearing Technologies and Mild Sensorineural Hearing Loss II: Current Research on Affordable Hearing Technologies and Direct-to-Consumer Models
Authors: Johnson Carole , Danhauer Jeffrey , Jilla Anna 
Published: June 2018

AbstractRecently, President Trump signed into law the Food and Drug Administration (FDA) Reauthorization Act of 2017, which included the Over-the-Counter Hearing Aid Act designed to provide greater public accessibility to and affordability of amplification for individuals with self-identified mild and moderate hearing loss through the provision of over-the-counter (OTC) hearing aids (HAs) with a direct-to-consumer (DTC) delivery model. American Speech-Language-Hearing Association and American Academy of Audiology Position Statements on OTC HAs state that these devices should only be used for adults with mild hearing losses. DTC amplification and service delivery has been available to consumers in a variety of forms for a significant period of time. However, FDA-regulated OTC HAs will not be available as described in the new law until the FDA publishes the required guidance related to the technology, safety, and labeling of such devices. With the clear similarities in mind between present and future amplification options, a literature search was conducted to review studies assessing outcomes for low-cost and DTC HAs and service-delivery models to inform what we may expect as OTC HAs enter the market. Nine studies were identified which assessed: (1) electroacoustic capabilities of low-cost and DTC HAs, (2) use of these devices in field trials, or (3) efficacy of DTC models. None of the studies reported outcomes specifically for participants with mild hearing loss. The studies had poor external validity because none included all factors that would exist in realistic uses of OTC HAs within a DTC model. Additional research will be needed as OTC HAs become available and different delivery models are proposed.
Healthcare consumers’ sensitivity to costs: a reflection on behavioural economics from an emerging market
Authors: Vuong Quan-Hoang , Ho Tung-Manh , Nguyen Hong-Kong , Vuong Thu-Trang 
Published: June 2018

AbstractDecision-making regarding healthcare expenditure hinges heavily on an individual's health status and the certainty about the future. This study uses data on propensity of general health exam (GHE) spending to show that despite the debate on the necessity of GHE, its objective is clear—to obtain more information and certainty about one’s health so as to minimise future risks. Most studies on this topic, however, focus only on factors associated with GHE uptake and overlook the shifts in behaviours and attitudes regarding different levels of cost. To fill the gap, this study analyses a dataset of 2068 subjects collected from Hanoi (Vietnam) and its vicinities using the baseline-category logit method. We evaluate the sensitivity of Vietnamese healthcare consumers against two groups of factors (demographic and socioeconomic-cognitive) regarding payment for periodic GHE, which is not covered by insurance. Our study shows that uninsured, married and employed individuals are less sensitive to cost than their counterparts because they value the information in reducing future health uncertainty. The empirical results challenge the objections to periodic health screening by highlighting its utility. The relevance of behavioural economics is further highlighted through a look at the bounded rationality of healthcare consumers and private insurance companies in using and providing the service, respectively.
Squeezing and stick–slip friction behaviors of lubricants in boundary lubrication
Authors: Xu Rong-Guang , Leng Yongsheng 
Published: June 2018

SignificanceLubricant films under extreme confinement at nanometer scales play a crucial role in lubrication engineering. Improved understanding of squeezing and friction behaviors of such ultrathin films can lead to strategies for preventing surface failure and efficient national energy usage. Through computer simulations we show that lubricant films under compression can solidify below some critical monolayers distance. Under sliding friction these solidified films exhibit stick–slip friction in which the slip occurs at solid–lubricant interfaces. However, dilation of the lubricant during slips (a signature of shear melting) is never observed, which is consistent with other experimental findings. These insights, with strong support from surface force balance experiments, may open the way to improved lubricant design.
Healing tourists with religion: Saint Rita's cult in Poland.
Authors: Kuźma I. B. 
Published: June 2018

Abstract

This chapter examines the emergence of the cult of St Rita of Cascia in Poland, in Krakow in particular, where the post-communist era has seen the development, especially in Catholic areas, of new processional routes associated with transnational cults. An examination of the Polish petitions of the faithful directed to St Rita has shown that most requests concern physical and mental health.
Saint Rita of Cascia: an evolving devotion in Dublin's inner city.
Authors: Kiely T. 
Published: June 2018

Abstract

This chapter explores the evolution and anatomy of the devotional practice among a predominantly female congregation, who attend a weekly novena mass in Dublin, Ireland, to seek favours and support from a saint (St Rita of Cascia) who is simultaneously a figure from medieval Italy and an ordinary woman like them, who understands their ongoing practical worries.
Deep convolutional networks for quality assessment of protein folds
Authors: Derevyanko Georgy , Grudinin Sergei , Bengio Yoshua , Lamoureux Guillaume 
Published: June 2018

AbstractMotivationThe computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined as complex functions of the atomic coordinates. However, very few methods have attempted to learn these features directly from the data.ResultsWe show that deep convolutional networks can be used to predict the ranking of model structures solely on the basis of their raw three-dimensional atomic densities, without any feature tuning. We develop a deep neural network that performs on par with state-of-the-art algorithms from the literature. The network is trained on decoys from the CASP7 to CASP10 datasets and its performance is tested on the CASP11 dataset. Additional testing on decoys from the CASP12, CAMEO and 3DRobot datasets confirms that the network performs consistently well across a variety of protein structures. While the network learns to assess structural decoys globally and does not rely on any predefined features, it can be analyzed to show that it implicitly identifies regions that deviate from the native structure.Availability and implementationThe code and the datasets are available at https://github.com/lamoureux-lab/3DCNN_MQA.Supplementary informationSupplementary data are available at Bioinformatics online.
PTPN11 Gain-of-Function Mutations Affect the Developing Human Brain, Memory, and Attention
Authors: Johnson Emily M , Ishak Alexandra D , Naylor Paige E , Stevenson David A , Reiss Allan L , Green Tamar 
Published: June 2018

AbstractThe Ras-MAPK pathway has an established role in neural development and synaptic signaling. Mutations in this pathway are associated with a collection of neurodevelopmental syndromes, Rasopathies; among these, Noonan syndrome (NS) is the most common (1:2000). Prior research has focused on identifying genetic mutations and cellular mechanisms of the disorder, however, effects of NS on the human brain remain unknown. Here, imaging and cognitive data were collected from 12 children with PTPN11-related NS, ages 4.0–11.0 years (8.98 ± 2.33) and 12 age- and sex-matched typically developing controls (8.79 ± 2.17). We observe reduced gray matter volume in bilateral corpus striatum (Cohen’s d = −1.0:−1.3), reduced surface area in temporal regions (d = −1.8:−2.2), increased cortical thickness in frontal regions (d = 1.2–1.3), and reduced cortical thickness in limbic regions (d = −1.6), including limbic structures integral to the circuitry of the hippocampus. Further, we find high levels of inattention, hyperactivity, and memory deficits in children with NS. Taken together, these results identify effects of NS on specific brain regions associated with ADHD and learning in children. While our research lays the groundwork for elucidating the neural and behavioral mechanisms of NS, it also adds an essential tier to understanding the Ras-MAPK pathway’s role in human brain development.
TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress
Authors: Jones John L , Peana Deborah , Veteto Adam B , Lambert Michelle D , Nourian Zahra , Karasseva Natalia G , Hill Michael A , Lindman Brian R , Baines Christopher P , Krenz Maike , Domeier Timothy L 
Published: June 2018

AbstractAimsCardiomyocyte Ca2+ homeostasis is altered with aging via poorly-understood mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an osmotically-activated Ca2+ channel, and there is limited information on the role of TRPV4 in cardiomyocytes. Our data show that TRPV4 protein expression increases in cardiomyocytes of the aged heart. The objective of this study was to examine the role of TRPV4 in cardiomyocyte Ca2+ homeostasis following hypoosmotic stress and to assess the contribution of TRPV4 to cardiac contractility and tissue damage following ischaemia–reperfusion (I/R), a pathological condition associated with cardiomyocyte osmotic stress.Methods and resultsTRPV4 protein expression increased in cardiomyocytes of Aged (24–27 months) mice compared with Young (3–6 months) mice. Immunohistochemistry revealed TRPV4 localization to microtubules and the t-tubule network of cardiomyocytes of Aged mice, as well as in left ventricular myocardium of elderly patients undergoing surgical aortic valve replacement for aortic stenosis. Following hypoosmotic stress, cardiomyocytes of Aged, but not Young exhibited an increase in action-potential induced Ca2+ transients. This effect was mediated via increased sarcoplasmic reticulum Ca2+ content and facilitation of Ryanodine Receptor Ca2+ release and was prevented by TRPV4 antagonism (1 μmol/L HC067047). A similar hypoosmotic stress-induced facilitation of Ca2+ transients was observed in Young transgenic mice with inducible TRPV4 expression in cardiomyocytes. Following I/R, isolated hearts of Young mice with transgenic TRPV4 expression exhibited enhanced contractility vs. hearts of Young control mice. Similarly, hearts of Aged mice exhibited enhanced contractility vs. hearts of Aged TRPV4 knock-out (TRPV4−/−) mice. In Aged, pharmacological inhibition of TRPV4 (1 μmol/L, HC067047) prevented hypoosmotic stress-induced cardiomyocyte death and I/R-induced cardiac damage.ConclusionsOur findings provide a new mechanism for hypoosmotic stress-induced cardiomyocyte Ca2+ entry and cell damage in the aged heart. These finding have potential implications in treatment of elderly populations at increased risk of myocardial infarction and I/R injury.
Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation
Authors: Graves Scott S , Parker Maura H , Storb Rainer 
Published: June 2018

Abstract
Since its inception in the 1950s, hematopoietic cell transplantation (HCT) has become a highly effective clinical treatment for malignant and nonmalignant hematological disorders. This milestone in cancer therapy was only possible through decades of intensive research using murine and canine animal models that overcame what appeared in the early days to be insurmountable obstacles. Conditioning protocols for tumor ablation and immunosuppression of the recipient using irradiation and chemotherapeutic drugs were developed in mouse and dog models as well as postgrafting immunosuppression methods essential for dependable donor cell engraftment. The random-bred canine was particularly important in defining the role of histocompatibility barriers and the development of the nonmyeloablative transplantation procedure, making HCT available to elderly patients with comorbidities. Two complications limit the success of HCT: disease relapse and graft versus host disease. Studies in both mice and dogs have made significant progress toward reducing and to some degree eliminating patient morbidity and mortality associated with both disease relapse and graft versus host disease. However, more investigation is needed to make HCT more effective, safer, and available as a treatment modality for other non-life-threatening diseases such as autoimmune disorders. Here, we focus our review on the contributions made by both the murine and canine models for the successful past and future development of HCT.
An ultraspherical spectral method for linear Fredholm and Volterra integro-differential equations of convolution type
Authors: Hale Nicholas 
Published: June 2018

Abstract
The Legendre-based ultraspherical spectral method for ordinary differential equations (Olver, S. & Townsend, A. (2013) A fast and well-conditioned spectral method. SIAM Rev., 55, 462–489.) is combined with a formula for the convolution of two Legendre series (Hale, N. & Townsend, A. (2014a) An algorithm for the convolution of Legendre series. SIAM J. Sci. Comput., 36, A1207–A1220.) to produce a new technique for solving linear Fredholm and Volterra integro-differential equations with convolution-type kernels. When the kernel and coefficient functions are sufficiently smooth, then the method is spectrally accurate and the resulting almost-banded linear systems can be solved with linear complexity.
Basic knowledge
Authors: Cascarini Luke , Schilling Clare , Gurney Ben , Brennan Peter 
Published: June 2018

Abstract
This chapter discusses basic knowledge in oral and maxillofacial surgery, including Anatomy of the teeth, Dental occlusion, Anatomy of the oral cavity, Anatomy of the facial skeleton, Anatomy of the orofacial muscles, nerves, and glands, Anatomy of the neck, Medical clerking: history and full body examination, Examination of the oral cavity and Examination of the face and neck
Living the spectre of forced return: negotiating deportability in British immigration detention
Authors: Turnbull Sarah 
Published: June 2018

Abstract
Immigration detention and deportation are being increasingly utilised in many countries as key state responses to irregular migration. These practices work together to force migrants to their countries of origin or third countries, offering limited choice about whether to stay or leave. Drawing on a multi-sited ethnographic study of British immigration detention, this paper explores how detainees negotiate deportability and their accounts of the spectre of departing the United Kingdom, often against their wishes and occasionally by force. It analyses how deportability and the institutional structures and logics of immigration detention coalesce to shape detainees’ understandings of their positions and options as deportable subjects. The paper highlights the materiality of return from immigration detention and the complexities and multiplicities of how detainees account for their possible departures in relation to the themes of identity, belonging, and home. British immigration removal centres can be understood as ‘sites of struggle’ in which those subject to detention and deportation negotiate these interconnected practices, acting as best they can within coercive and isolating carceral institutions.
Observability of planet–disc interactions in CO kinematics
Authors: Pérez Sebastián , Casassus S , Benítez-Llambay P 
Published: June 2018

ABSTRACT
Empirical evidence of planets in gas-rich circumstellar discs is required to constrain giant planet formation theories. Here we study the kinematic patterns which arise from planet–disc interactions and their observability in CO rotational emission lines. We perform 3D hydrodynamical simulations of single giant planets and predict the emergent intensity field with radiative transfer. Pressure gradients at planet-carved gaps, spiral wakes, and vortices bear strong kinematic counterparts. The isovelocity contours in the CO(2-1) line centroids $v$○ reveal large-scale perturbations, corresponding to abrupt transitions from below sub-Keplerian to super-Keplerian rotation along with radial and vertical flows. The increase in line optical depth at the edge of the gap also modulates $v$○, but this is a mild effect compared to the dynamical imprint of the planet–disc interaction. The large-scale deviations from the Keplerian rotation thus allow the planets to be indirectly detected via the first moment maps of molecular gas tracers, at Atacama Large Millimetre/submillimetre Array angular resolutions. The strength of these deviations depends on the mass of the perturber. This initial study paves the way to eventually determine the mass of the planet by comparison with more detailed models.