bluuebunny/crossref_metadata_2025_split huggingface dataset:
VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1
Authors: Jung Oisun , Beauvais DeannaLee M. , Adams Kristin M. , Rapraeger Alan C. 
Published: September 2019

ABSTRACT
When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2 activates VLA-4-mediated motility has remained unknown. We now report that VEGFR2 causes PKA-mediated phosphorylation of VLA-4 on S988, an event known to stimulate tumor metastasis while suppressing cytotoxic immune cells. A key partner in this mechanism is the chemokine receptor CXCR4, a well-known mediator of cell motility in response to gradients of the chemokine SDF-1 (also known as CXCL12). The entire machinery necessary to phosphorylate VLA-4, consisting of CXCR4, AC7 (also known as ADCY7) and PKA, is constitutively associated with VEGFR2 and is localized to the integrin by Sdc1. VEGFR2 carries out the novel phosphorylation of Y135 within the DRY microswitch of CXCR4, sequentially activating Gαiβγ, AC7 and PKA, which phosphorylates S988 on the integrin. This mechanism is blocked by a syndecan-mimetic peptide (SSTNVEGFR2), which, by preventing VEGFR2 linkage to VLA-4, arrests tumor cell migration that depends on VLA-4 phosphorylation and stimulates the LFA-1-mediated migration of cytotoxic leukocytes.
Хемотаксономическое изучение Spiraea aemiliana в сравнении с близкородственными видами S. betulifolia и S. beauverdiana
Authors: Kostikova V.A. , Kuznetsov A.A. , Tishchenko E.D. , Fayzylkhakova A.N. 
Published: September 2019

Методом ВЭЖХ изучены состав и содержание фенольных соединений в листьях Spiraea aemiliana Schneid. из 2 природных популяций, произрастающих на острове Кунашир. Проведено сравнение хроматографических профилей S. aemiliana и близкородственных видов S. betulifolia Pall. и S. beauverdiana Schneid. В 40 % водно-этанольных экстрактах из листьев S. aemiliana выявлено 19 соединений. Из них идентифицированы хлорогеновая, n-кумаровая и коричная кислоты, кверцетин, кемпферол, гиперозид, изокверцитрин, рутин, авикулярин, астрагалин и дигидрокверцетин. Специфичным соединением в листьях S. aemiliana является изокверцитрин, не идентифицированный у других близких видов. Хроматографические профили S. aemiliana и S. betulifolia в целом очень сходны. Это является дополнительным доказательством мнения учёных о таксономическом ранге S. aemiliana как подвида, вариации или формы S. betulifolia. По количественному содержанию фенольных соединений S. aemiliana (сумма фенольных соединений варьирует от 16,4 до 23,88 мг/г) более сходна с S. beauverdiana. Листья S. aemiliana содержат много гиперозида (до 9,50 мг/г), что практически в два раза больше, чем у S. beauverdiana (до 4,3 мг/г) и в 6 раз у S. betulifolia (до 1,55 мг/г). Выявленная разница в содержании гиперозида между тремя таксонами Spiraea статистически достоверна.
Биометрические параметры некоторых млекопитающих Кочкорской долины
Authors: Imanaliev T.I. 
Published: September 2019

Изучению животных Кочкорской долины, также как и территории Кыргызстана, положили начало такие видные зоологи, как Н. А. Северцов (1877 г), Д. Н. Кашкаров (1923-1926 гг), В. Н. Шнитников (1936 г), Д. П. Дементьев (1938-1955 гг). В результате проведенных ими исследований выявлен видовой состав, распространение и биологические особенности некоторых видов животных. Основываясь на вышеизложенном была признана актуальность изучения биоты Кочкорской долины и целью данного исследования было: уточнение фауны млекопитающих; определение биометрических параметров некоторых индикаторных видов млекопитающих.
Polyphonic Theology of the Fathers/polyphone Theologie der Kirchenväter. Bemerkungen zu einem Konzept und seiner Brauchbarkeit
Authors: Markschies Christoph 
Published: September 2019

Abstract
The contribution is presenting a new focus on the development of Christian theology in Antiquity: the idea of a polyphonic theology of the Fathers. This idea uses the term ›polyphony‹, well established in music theory and in certain forms of Literary criticism and Biblical theology, to describe a certain structured plurality in the concepts of certain individual ancient theologians and in the overall design of Christian theology in Antiquity. The first part gives certain details about the term ›polyphony‹ used to describe forms of thinking, like polyphony in music consists of two or more lines of melody of certain independence (opposed to homophony), the second part asks which new insights one can get using the new idea to analyze ancient Christian literature and the third part deals with certain problems of the approach.
Theodoret of Cyrus. An Access to the polyphonic context of Antiochia
Authors: Bergjan Silke-Petra 
Published: September 2019

Abstract
Polyphonie im Fall Theodorets lässt sich beziehen auf den vielstimmigen Kontext, den wir in seiner Wirkungsstätte Antiochia im 5. Jahrhundert antreffen. Polyphonie kann aber auch das Zusammenspiel der verschiedenen dogmatischen Themen bei Theodoret meinen. Im Folgenden sollen seine Äußerungen zur Providenz Gottes einen Einblick in seine Person geben und eine breitere Perspektive ermöglichen, die aus der Engführung auf cyrillische Themen herausführt. Die Christologie ist für Theodoret Teil der Providenz Gottes. Theodoret äussert sich in drei Schriften zur Providenz Gottes: Graecarum affectionum curatio, De providentia orationes decem und Haereticarum fabularum compendium. Die Texte zeigen, dass es in Antiochia eine Diskussion um die Rede vom Fleisch Christi als Hülle der Gottheit gegeben hat, dass Theodoret hiervon Distanz nimmt und sich ganz auf die Menschwerdung als Annahme der ganzen menschlichen Natur konzentriert.
Impulse aus der Augustinforschung
Authors: Henning Drecoll Volker 
Published: September 2019

Abstract
Research in Augustine is manifold. Recent scholarship in Germany focused upon Augustine‘s heresiology (esp. against Manichaeism, but also Pelagianism, Donatism, Priscillianism), the controversy with Neoplatonism, his exegesis (esp. in sermons and in de Genesi ad litteram), emotions (esp. for the description of sin and grace), and his widespread correspondence. As important impulses for modern theology, his concept of God may be of special interest. God establishes his will in time and history and cannot be urged against his will. This is the presupposition not only for Augustine’s christology and pneumatology, but also for his understanding of history and his doctrine of grace. The latter takes into consideration the social context of human beings, the emotional character of voluntary decisions and the ongoing development of individual identity. Furthermore, good and evil are not equal options, but the good is only possible if God enables the individual to act according to his insights and exerts a direct influence upon one's will. Insights or knowledge are not salvific by themselves, but belong to one’s development that leads to a better understanding of creation and revelation exactly when it is orientated towards God’s salvific operations.
Revista Claudia: a discursivização da mulher e do casamento durante a segunda metade do século xx
Authors: Carneiro Ceres Ferreira 
Published: September 2019

Trazemos uma reflexão sobre como a imprensa feminina brasileira contribuiu para a homogeneização de sentidos sobre o feminino e sobre o casamento, durante o século XX, com destaque para as respostas dadas por Carmen da Silva às cartas enviadas ao “consultório sentimental” da revista feminina Claudia.
Palavras-chave: Revista feminina. Análise do Discurso. Casamento.

ABSTRACT
We bring a reflection on how the Brazilian women's press contributed to the homogenization of meanings over the feminine as well marriage during the twentieth century, especially the answers given by Carmen da Silva to the letters sent to the "sentimental consulting room" of the women's magazine Claudia.
Keywords: Women’s press. Discourse Analysis. Marriage.
SIMULASI PERUBAHAN PENGGUNAAN LAHAN DENGAN KONSEP CELLULER AUTOMATA DI KOTA MATARAM
Authors: Putra Muhammad Rusdin Rangga , Rudiarto Iwan 
Published: September 2019

Dinamika perubahan penggunaan lahan dapat dipahami secara spasial dengan memanfaatkan data penginderaan jauh dan sistem informasi geografis. Penelitian ini bertujuan membangun model perubahan penggunaan lahan di Kota Mataram untuk memprediksi penggunaan lahan di Kota Mataram pada tahun2031. Model yang dibangun adalah hasil analisis spasial dari pola perubahan penggunaan lahan dari kurun waktu tahun 2008 sampai tahun 2017 dengan menggunakan konsep cellular automata. Penentuan aturan transisi dan faktor-faktor pendorong perubahan lahan serta nilai pengaruh (bobot) masing-masing faktor tersebut merupakan hal yang penting untuk membangun model prediksi perubahan lahan. Hasil perhitungan validitas model menujukkan tingkat akurasi model sebesar 84,18%. Dari tahun 2017 sampai tahun 2031 terjadi peningkatan secara signifikan luasan penggunaan lahan industri dan pergudangan, perdagangan dan jasa, dan permukiman di Kota Mataram berturut-turut sebesar 9,861 hektar, 355,354 hektar, dan 482,697 hektar. Pemanfaatan simulasi perubahan penggunaan lahan dengan konsep Cellular Automata ini dapat diterapkan untuk mengevaluasi Rencana Tata Ruang dan Wilayah Kota.
Fast and simple dataset selection for machine learning
Authors: Peter Timm J. , Nelles Oliver 
Published: September 2019

Abstract
The task of data reduction is discussed and a novel selection approach which allows to control the optimal point distribution of the selected data subset is proposed. The proposed approach utilizes the estimation of probability density functions (pdfs). Due to its structure, the new method is capable of selecting a subset either by approximating the pdf of the original dataset or by approximating an arbitrary, desired target pdf. The new strategy evaluates the estimated pdfs solely on the selected data points, resulting in a simple and efficient algorithm with low computational and memory demand. The performance of the new approach is investigated for two different scenarios. For representative subset selection of a dataset, the new approach is compared to a recently proposed, more complex method and shows comparable results. For the demonstration of the capability of matching a target pdf, a uniform distribution is chosen as an example. Here the new method is compared to strategies for space-filling design of experiments and shows convincing results.
Nonlinear dynamic behaviors of outer shell and upper deck structures subjected to impact loading in maritime environment
Authors: Prabowo Aditya Rio , Sohn Jung Min 
Published: September 2019

Abstract
Ship collision appears as the most threatening loading accounting for structural casualties and numbers of casualties after impact on the target ship. In order to avoid such losses against collision, better safety during activities in maritime environment is demanded. Therefore, assessment of ship structure is needed to understand dynamic effect of the impact and quantify nonlinear behavior of local members. This study is conducted to achieve those aims by deploying nonlinear finite element analysis (NLFEA) to idealized ship collision event. Validation of the numerical method is performed by comparing results of a modeled collision case with various empirical calculations. Design for impact loading in main analysis considers side collision to main hull structure, which single side skin (SSS) and double side skin (DSS) types are modeled. Investigation is also directed to influence of the target members on the main hull to capacity of absorbed energy and characteristic of structural resistance. Analysis results indicate that good understanding is successfully obtained in terms of structural damage-energy relation. Confirmation of the current calculation using numerical calculation is also confirmed considering the modeled cases and empirical results agree well. Tendency of hull responses concluded that the longitudinal members contribute more to structural resistance against side collision.
Experimental and simulation investigation on spring-in deformation for L-shape component
Authors: Gajjar Tushar , Shah Dhaval B. , Joshi S. J. , Patel K. M. 
Published: September 2019

Abstract
The angular deformation is key parameter in composite manufacturing for curvature surfaces. Process Induced Distortions (PID’s) are a major problem while manufacturing a composite part using autoclave process. Spring-back or spring-in is one of the PID in autoclave process. Spring-in effect either increase or decrease at angled section during curing of composite laminates. In this paper, L-shaped composite part has been manufactured using autoclave process. The material properties like glass transition temperature, heat reaction, crystallization temperature, Coefficient of Thermal Expansion have been measured for the cured component by using various testing techniques. Spring-in angle has been found for various number of layers and layup orientation. The simulation has been performed in ABAQUS software along with the COMPRO plug-in for each component. The variation of spring-in angle has been observed with changing material properties. The experimental results have been compared with simulation results. The percentage variation of spring-in deformation for experimental and simulation results has been found in the range of 5-7%.
An Investigation into the Underpinning Factors of Plagiarism among Universities in Iran
Authors: Shaghaghi Mahdi , Vasfi Mohammad-Reza 
Published: September 2019

AbstractWe are living in a time where plagiarism is a highly critical issue in the publish-or-perish stage of academic life. There have been many efforts to address this issue by holistic socio-cognitive variables but they do not seem explanatory enough in context-specific areas. Therefore, we aimed to investigate the root causes of plagiarism in a specific context, i. e. Iranian universities, by offering a structural model to reveal the building blocks of this phenomenon. Setting the goal, we chose Corbin and Strauss’s (2008) Grounded Theory (GT) approach, avoiding its paradigmatic cliché that a theoretical model emerges only from data without any pre-assumption. The research population included faculty members, PhD candidates and master’s students selected from universities in Tehran, Iran. Open theoretical sampling and, then, discriminative sampling were used. Fifty-one interviews, two newspaper interviews, and three focus groups were conducted. The interviewees were accessed through universities’ library and information centers. Taken together, 56 interviews were transcribed and codified. Lincoln and Guba’s (2008) criteria were used to control the quality of the research process. “Indifference” to plagiarism is the central phenomenon and “cultural depositories” plus “governmental capitalism” were found to be the root factors. These two factors may lead to “Bureaucratic university” (Moodie 2006) as a context for the emergence of “research formalism”, “uncritical education” and “scholastic habitus”. All these factors, together with direct reflexive elements including bad exemplars, the irresponsibility of professors, immoral trade-off, unscientific evaluation, insignificant differentiation, and vindications, lead to “indifference”. One of the research’s implications is that plagiarism in Iran seems not to result from individual-psychological factors but from cultural, economic, legal and organizational factors. Another implication is that in the investigation of social or organizational problems we should take a look at the concept of normality. We explored the factors tending to make a problem a normal phenomenon. We also pinpointed the things making people indifferent to a problem, factors pushing abnormal phenomenon to the realm of normality, and elements constituting the origins of the current order of things which are mysteriously silenced and practically behaved.
Promoting Equal Access to Public Digital Cultural Services in China: Efforts and Challenges
Authors: Wanyan Dengdeng , Dai Yanqing 
Published: September 2019

Abstract
With the development of information technology and the advent of the digital era, the digitization of cultural heritage and the internet-based equal access to the digitized heritage have received worldwide attention. Taking China as a case study, this paper reviews its efforts and challenges to promote equal access to public digital cultural services (PDCS). It starts by introducing the efforts, including PDCS-related legislations, policies and standards issued by the government, and major government-initiated PDCS projects. They are followed by an analysis of its challenges, including deficiencies in government funding, internet penetration, broadband access rates in the Central and Western regions and rural areas, and the limited digital literacy, cultural knowledge, and income levels of certain population groups. This study concludes with the suggestion that promoting equal access to PDCS in less developed regions, rural areas, and vulnerable groups is still an important task in China, and the government needs to work with private sector partners to overcome the challenges.
Changes in Scholarly Reading in Finland Over a Decade: Influences of E-Journals and Social Media
Authors: Tenopir Carol , Late Elina , Talja Sanna , Christian Lisa 
Published: September 2019

Abstract
Nationwide surveys of researchers in Finland in 2007 and 2016 distributed with the assistance of FinELib, the Finnish national consortium, show that researchers use a growing range of sources to find and access scholarly articles and that some reading patterns are changing. The percentage of articles found by searching and browsing are decreasing, while researchers are using more social ways to locate articles. Research social networking sites are rated as important to their work. They read more on-screen, although still print some material out for final reading. Reading patterns for books are different, as researchers still rely more on printed books than e-books, in spite of an increase in e-book collections through their libraries. This study shows a continuous process of incremental change, enabled by changes in scholarly publishing, social networking, and library collection decisions. More changes can be expected, as researchers adopt systems and patterns that fit with their work patterns and make the finding, locating, and reading of scholarly materials easier. Libraries must both lead and adapt to these new reading patterns by providing links and access to a variety of journal services and by maintaining a balance of print and e-book collections.
Crystal structure of 12-(2-hydroxybenzoyl)benzo[f]pyrido[1,2-a]indole-6,11-dione, C23H13NO4
Authors: Luo Peng , Chittiboyina Amar G. , Wang Mei , Khan Ikhlas A. , Pan Wei-Gao , Wei Wan-Xing 
Published: September 2019

Abstract
C23H13NO4, monoclinic, P21/n (no. 14), a = 11.6537(6) Å, b = 5.1315(2) Å, c = 26.8047(13) Å, β = 96.266(3)°, V = 1593.4(13) Å3, Z = 4, R
gt(F) = 0.0531, wR
ref(F
2) = 0.1432, T = 90.0(5) K.
Towards Computer Simulations of Virtue Ethics
Authors: Lasquety-Reyes Jeremiah A. 
Published: September 2019

Abstract
This article presents two approaches for computer simulations of virtue ethics in the context of agent-based modeling, a simple way and a complex way. The simple way represents virtues as numeric variables that are invoked in specific events or situations. This way can easily be implemented and included in social simulations. On the other hand, the complex way requires a PECS framework: physical, cognitive, emotional, and social components need to be implemented in agents. Virtue is the result of the interaction of these internal components rather than a single variable. I argue that the complex way using the PECS framework is more suitable for simulating virtue ethics theory because it can capture the internal struggle and conflict sometimes involved in the practice of virtue. To show how the complex way could function, I present a sample computer simulation for the cardinal virtue of temperance, the virtue that moderates physical desires such as food, drink, and sex. This computer simulation is programmed in Python and builds upon the well-known Sugarscape simulation.1
Indikatorensystem zur Förderung der Ergebnisqualität in der stationären Langzeitpflege
Authors: Kelleter Heidemarie 
Published: September 2019

Zusammenfassung
Durch eine Neuregelung in der Pflegeversicherung soll die Qualität in der stationären Langzeitpflege durch Indikatoren vergleichbar werden. Anhand der Umsetzung des webbasierten Lernkonzepts zur indikatorengestützen Qualitätsförderung (inQS) kann dieser Effekt der Vergleichbarkeit bereits aufgezeigt werden. Wirkungen sind dabei in der digitalisierten Einführung der Indikatoren, dem Umgang mit Routinedaten sowie der Interpretation von Qualitätskennzahlen ersichtlich.
Neue Konzeption für Qualitätsbeurteilungen und die öffentliche Qualitätsdarstellung in der Langzeitpflege
Authors: Wingenfeld Klaus 
Published: September 2019

Zusammenfassung
Ab Herbst 2019 erfolgt in Deutschland eine grundlegende Umstellung des Systems der Qualitätsbeurteilung und der öffentlichen Qualitätsberichterstattung im Bereich der pflegerischen Versorgung. Zunächst in der stationären Versorgung, später auch in der ambulanten Pflege werden neue Inhalte und Methoden der Qualitätsbewertung eingeführt. Der Beitrag skizziert die wichtigsten Änderungen, die mit diesem Prozess eingeleitet werden.
Qualitätsmanagement in der Gesundheitsförderung – Das Gute besser machen
Authors: Hillenbrand Ann-Katrin , Walentzak Bettina , Heyn Martin 
Published: September 2019

Zusammenfassung
Qualität bezieht sich darauf, wie Standards, Anforderungen und Kriterien, die zuvor definiert wurden, erfüllt werden. Qualität ist damit auch immer eine Frage der Perspektive, denn Kriterien können unterschiedlich gewichtet werden [Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit (LGL) Herausgeber. Qualität in Gesundheitsförderung und Prävention. Dokumentation der Workshopreihe 2017 mit Prof. Dr. Petra Kolip. Band 7 der Schriftenreihe des ZPG. 2018]. Der vorliegende Beitrag beleuchtet das Verständnis von Qualitätskriterien insbesondere aus Landeszentrumsperspektive – hier mit Bezug zum Aufgabenspektrum und zu den Tätigkeitsfeldern des Bayerischen Zentrums für Prävention und Gesundheitsförderung (ZPG).
Unzureichende Qualität an Klinikstandorten? Erste Ergebnisse des Verfahrens Planungsrelevante Qualitätsindikatoren
Authors: Zander-Jentsch Britta , Klein Silvia 
Published: September 2019

Zusammenfassung
Das Verfahren der vom G-BA im Dezember 2016 beschlossenen planungsrelevanten Qualitätsindikatoren soll die Krankenhausplanung durch Qualitätsdaten der Krankenhäuser unterstützen. Die Ergebnisse des ersten Jahres zeigen, dass an 71 dt. Krankenhäusern insgesamt 73 als „unzureichende Qualität“ bewertete Versorgungsaspekte in drei Leistungsbereichen identifiziert wurden. Das Verfahren wird derzeit weiterentwickelt, um zukünftig die Versorgungsqualität ganzer Fachabteilungen planungsrelevant abzubilden.
Patientensicherheit im Spannungsfeld von Risiko- und Qualitätsmanagement – Versuch einer Verortung
Authors: Rosentreter Michael 
Published: September 2019

Zusammenfassung
Der Versuch, die Patientensicherheit im Verhältnis zum Risiko- und Qualitätsmanagement zu verorten, führt zur Sicherheitskultur. Die Umsetzung einer solchen Kultur der Transparenz und des Lernens erfordert ein neues Verständnis von Management, damit die Sicherheitsbedürfnisse aller Menschen in einer Organisation befriedigt werden: Von einem Klima skeptischer Kontrolle hin zu vertrauensvollem Umgang mit Fehlern und Kritik.