bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perimeter-Minimizing Triple Bubbles in the Plane and the 2-Sphere
Authors: Lawlor Gary R. 
Published: July 2019

Abstract
We use continuous and discrete unification to prove that standard triple bubbles in ℝ2 and 𝕊2 are the minimizers of perimeter, among all clusters (Definition 2.3) enclosing the same triple of areas.
Unification defines a unified measurement that allows all configurations, regardless of areas, to compete together. Continuous unification proves that if a unified minimizer were better than expected, it would have to have at least one interior bubble component. Discrete unification proves there can only be one interior bubble and that it must be connected. This leaves only the “daisy” configurations: one interior bubble surrounded by an even number of “petals.” A more careful analysis also eliminates these, leaving only the standard triple bubbles as minimizers.
The result on the sphere is new; the result in the plane is due to Wichiramala [11]. The double bubble in the sphere was done by Masters [6].
A new indirect estimation of reference intervals: truncated minimum chi-square (TMC) approach
Authors: Wosniok Werner , Haeckel Rainer 
Published: July 2019

Abstract
All known direct and indirect approaches for the estimation of reference intervals (RIs) have difficulties in processing very skewed data with a high percentage of values at or below the detection limit. A new model for the indirect estimation of RIs is proposed, which can be applied even to extremely skewed data distributions with a relatively high percentage of data at or below the detection limit. Furthermore, it fits better to some simulated data files than other indirect methods. The approach starts with a quantile-quantile plot providing preliminary estimates for the parameters (λ, μ, σ) of the assumed power normal distribution. These are iteratively refined by a truncated minimum chi-square (TMC) estimation. The finally estimated parameters are used to calculate the 95% reference interval. Confidence intervals for the interval limits are calculated by the asymptotic formula for quantiles, and tolerance limits are determined via bootstrapping. If age intervals are given, the procedure is applied per age interval and a spline function describes the age dependency of the reference limits by a continuous function. The approach can be performed in the statistical package R and on the Excel platform.
Competencies for improving diagnosis: an interprofessional framework for education and training in health care
Authors: Olson Andrew , Rencic Joseph , Cosby Karen , Rusz Diana , Papa Frank , Croskerry Pat , Zierler Brenda , Harkless Gene , Giuliano Michael A. , Schoenbaum Stephen , Colford Cristin , Cahill Maureen , Gerstner Laura , Grice Gloria R. , Graber Mark L. 
Published: July 2019

Abstract

Background
Given an unacceptably high incidence of diagnostic errors, we sought to identify the key competencies that should be considered for inclusion in health professions education programs to improve the quality and safety of diagnosis in clinical practice.

Methods
An interprofessional group reviewed existing competency expectations for multiple health professions, and conducted a search that explored quality, safety, and competency in diagnosis. An iterative series of group discussions and concept prioritization was used to derive a final set of competencies.

Results
Twelve competencies were identified: Six of these are individual competencies: The first four (#1–#4) focus on acquiring the key information needed for diagnosis and formulating an appropriate, prioritized differential diagnosis; individual competency #5 is taking advantage of second opinions, decision support, and checklists; and #6 is using reflection and critical thinking to improve diagnostic performance. Three competencies focus on teamwork: Involving the patient and family (#1) and all relevant health professionals (#2) in the diagnostic process; and (#3) ensuring safe transitions of care and handoffs, and “closing the loop” on test result communication. The final three competencies emphasize system-related aspects of care: (#1) Understanding how human-factor elements influence the diagnostic process; (#2) developing a supportive culture; and (#3) reporting and disclosing diagnostic errors that are recognized, and learning from both successful diagnosis and from diagnostic errors.

Conclusions
These newly defined competencies are relevant to all health professions education programs and should be incorporated into educational programs.
Skeletal myopathies as a non-cardiac cause of elevations of cardiac troponin concentrations
Authors: Giannitsis Evangelos , Mueller Christian , Katus Hugo A. 
Published: July 2019

Abstract
Skeletal myopathies have been suggested as a non-cardiac cause of elevations of cardiac troponin (cTn), particularly cardiac troponin T (cTnT). This is of major clinical relevance and concern as cTn plays a major role in the early diagnosis of myocardial infarction (MI). While both the incidence as well as the true pathophysiology (cardiac versus non-cardiac) underlying elevations in cTn in skeletal myopathies remain largely unknown, re-expression of cTnT in regenerating adult skeletal muscle has been suggested as a possible contributor. However, unequivocal protein characterization in skeletal muscle and quantification of the relative amounts of this possible signal versus the cTn signal derived from true cardiomyocyte injury remains elusive. Alternatively, minor cross-reactivity of the cTnT (and possibly at times also cTnI) detection and capture antibodies used in current monoclonal immunoassays with the skeletal troponin T or I isoform may be considered. Both would represent “false positive” elevations from a clinical perspective and would need to be reliably differentiated from “true positive elevations” from subclinical cardiomyocyte injury not detectable by currently available imaging techniques such as echocardiography and contrast enhanced magnetic resonance imaging (MRI), which have at least a 5 times lower sensitivity for cardiomyocyte injury. This review aims to explore the currently available data, its methodological limitations and provide guidance to clinicians to avoid misinterpretation of cTn concentrations.
Contractor’s bid pricing strategy: a model with correlation among competitors’ prices
Authors: Jaśkowski Piotr , Czarnigowska Agata 
Published: July 2019

Abstract
The approach used by construction companies to determine bid prices is an element of their strategy used to win jobs in competitive tenders. Such strategies build upon an analysis of the contactor’s potential and capabilities (am I able to deliver? am I eligible to participate in the tender?), and the analysis of the economic environment, including the expected behavior of competitors. The tender strategy sets out both the guidelines and the procedure in deciding whether or not to bid as well as the rules for determining the price. The price, on the one hand, should be high enough to cover expected direct and indirect costs as well as risk-adjusted profit. On the other hand, it needs to be low enough to be considered most attractive (typically: the lowest) among the prices offered by the competitors. The paper focuses on the price definition component of the bidding strategy. It provides a brief overview of the existing methods that support bidding decisions by comparing their demand for input and limitations in practical applications and presents a simulation-based method supporting the determination of the profit ratio. This probabilistic method assumes the existence of a positive correlation between the prices offered by the competitors. Its application is illustrated by means of a numerical example. The outcomes of the simulation prompt the amount of the profit margin that maximizes the expected value of the contractor’s profit.
Metapragmatic comments in web-based intercultural peer evaluation
Authors: Liu Ping , You Xiaoye 
Published: July 2019

AbstractPeer evaluation (PE) of student writings is increasingly conducted online these days, creating unique opportunities for intercultural communication. Adopting a socio-cognitive approach and drawing on data from an online exchange program between Chinese and American university students, the study examines how revision-oriented metapragmatic comments (MPCs) are used to adjust the salience of specific contextual factors in three dimensions: information (including socio-cultural, language, and writing knowledge), situational context, and interpersonal relations. The MPCs are found to have substantiated a host of pragmatic strategies, such as patterned moves, foregrounding or backgrounding information, evidentiality markers, dispreferred second turns, and highlighting group identity. Enhancing or degrading the salience of contextual factors, the MPCs facilitate the construction of a common ground between the Chinese and American students in terms of knowledge and personal affiliation. The use of revision-oriented MPCs in PE manifests the collaborative, mutually supportive nature of web-based intercultural communication.
The Impact of the Minimum Wage on Working Hours
Authors: Burauel Patrick , Caliendo Marco , Grabka Markus M. , Obst Cosima , Preuss Malte , Schröder Carsten 
Published: July 2019

AbstractThe present paper analyzes how the statutory minimum wage introduced on January 1, 2015, has affected working hours in Germany up to 2016. The data used come from the Socio-Economic Panel (SOEP), which provides not only contractual working hours but also actual hours worked. Using a difference-in-differences estimation approach, we find a significant and robust reduction incontractualworking hours among employees who are subject to social security contributions and earned less than the minimum wage before the introduction. The effect in 2015 is about −5 % and corresponds to a 1.7 hours reduction in average weekly working hours. The effect on actual hours is smaller and estimated less precisely. Extending the analysis until 2016 does not yield significant effects on contractual or actual working hours, while some specifications reject the common trend assumption.
International Trade or Technology? Who is Left Behind and What to do about it
Authors: Harrison Ann 
Published: July 2019

Abstract
We examine globalization’s effects on those left behind in both industrial and emerging markets. While access to global markets has lifted billions out of poverty in emerging markets, the benefits have not been equally shared. Increased competition through globalization as well as skill-biased technical change have hurt less educated workers in rich and poor countries. While much of the rising inequality is often attributed to globalization alone, a brief review of the literature suggests that labor-saving technology has likely played an even more important role. The backlash has focused on the negative consequences of globalization in developed countries, and now threatens the global trading system and access to that system for emerging markets. We conclude by proposing some solutions to compensate losers from the twin forces of technical change and globalization.
Effect of supplementation with omega-3 fatty acids on hypertriglyceridemia in pediatric patients with obesity
Authors: Del-Río-Navarro Blanca E. , Miranda-Lora América L. , Huang Fengyang , Hall-Mondragon Margareth S. , Leija-Martínez José J. 
Published: July 2019

Abstract

Background
The beneficial effects of treating hypertriglyceridemic adults with omega-3 fatty acids have been reported. However, information regarding omega-3 treatment of pediatric patients is limited. To evaluate the efficacy and safety of administering omega-3 fatty acids (3 g/day for 12 weeks) to children/adolescents with obesity and hypertriglyceridemia.

Methods
A randomized, double-blind, placebo-controlled, parallel study involving pediatric patients (10–16 years old) with obesity and hypertriglyceridemia was conducted. The National Center for Health Statistics (CDC) defines obesity as a body mass index (BMI) ≥95th percentile. Subjects with triglyceride concentrations ranging from 150 to 1000 mg/dL were randomized into two groups: those receiving omega-3 fatty acids (eicosapentaenoic and docosahexaenoic acids) (n = 65) and those receiving a placebo (n = 65) for 12 weeks. Serum triglyceride concentrations were always measured from 8 to 9 am after a 12-h fast.

Results
By the end of treatment, triglyceride concentrations had decreased by 39.1% in the omega-3 group and 14.6% in the placebo group (p < 0.01). The incidence of adverse gastrointestinal events (e.g. flatulence, belching) was 41.2% and 6.2% in the omega-3 and placebo groups, respectively (p < 0.01). There were no serious drug-related adverse events.

Conclusions
Supplementation with 3 g/day of omega-3 fatty acids is a safe and effective option for treating hypertriglyceridemia in children and adolescents with obesity.
A novel GATA6 variant in a boy with neonatal diabetes and diaphragmatic hernia: a familial case with a review of the literature
Authors: Gaisl Odile , Konrad Daniel , Joset Pascal , Lang-Muritano Mariarosaria 
Published: July 2019

AbstractGATA6gene variants come along with possible features such as pancreas agenesis/hypoplasia, neonatal diabetes and congenital heart defect. Congenital hypothyroidism, and hepatobiliary and gut abnormalities are also detectable. Children with congenital heart defects and neonatal diabetes were already described in 1970. GATA6 variants can be due tode novovariants or due to inherited variants. To date, 11 cases due to an inherited variant have been described. Herein we present a novel heterozygous GATA6 variant (c.1291C > T p.[Gln431*]) in a boy with transient neonatal diabetes, diaphragmatic hernia, congenital heart defect and early-onset scoliosis. The same variant was also present in the mother. At the age of 3 years, a random evaluation revealed a hemoglobin A1c(HbA1c) level of 7.8% (62 mmol/mol) without any diabetes-related symptoms. He was started on insulin therapy and HbA1cnormalized. A short review of the literature of hereditary cases of the GATA6 variant revealed the variable phenotypic spectrum and showed that patients with a mild phenotype are likely to have children with a more severe phenotype.
Chronic musculoskeletal pain, phantom sensation, phantom and stump pain in veterans with unilateral below-knee amputation
Authors: Allami Mostafa , Faraji Elahe , Mohammadzadeh Fatemeh , Soroush Mohammad Reza 
Published: July 2019

Abstract

Background and aims
Many individuals with lower limb loss report concerns about other musculoskeletal symptoms resulting from amputation. The objective of this study was to assess chronic musculoskeletal pain in Iranian veterans with unilateral below-knee amputation.

Methods
The participants agreed to take part in a health needs assessment and were interviewed face-to-face by trained interviewers. The assessment consisted of demographic information, wearing a prosthesis, pain locations in extremities, stump complications, severity of pains related to amputation and low back pain.

Results
Of 247 unilateral below knee amputees, 97.9% wore a prosthetic limb and times walking or standing with the prosthesis were 12.47 ± 3.84 and 4.22 ± 3.53 h a day, respectively. Low soft tissue coverage of the stump (15.4%) and symptomatic osteoarthritis in the contralateral lower extremity (40.1%) were the most common complications. The prevalence of stump pain, phantom sensations, phantom pain, low back pain, and knee pain was 84.2%, 77.3%, 73.7%, 78.1%, and 54.7% respectively. The odds ratio of stump pain in amputees with phantom pain was 2.22 times higher than those who did not experience phantom pain [OR = 2.22 (CI: 1.19–4.17); p = 0.012] and the odds ratio of low back pain was higher in amputees with stump pain [OR = 3.06 (CI: 1.50–6.21); p = 0.002].

Conclusions
This research enhances our understanding of comorbid musculoskeletal problems in below-knee amputees which can help health providers to identify rehabilitation needs and emphasizes the importance of regular assessments.

Implications
These findings underline the importance of paying closer attention to different dimensions and aspects of musculoskeletal complications in veterans with unilateral below-knee amputation.
Plasma Membrane Integrity During Cell–Cell Fusion and in Response to Pore-Forming Drugs Is Promoted by the Penta-EF-Hand Protein PEF1 inNeurospora crassa
Authors: Schumann Marcel René , Brandt Ulrike , Adis Christian , Hartung Lisa , Fleißner André 
Published: July 2019

AbstractIn this study, Schumann et al. identify the penta-EF-hand protein PEF1 of the genetic model fungus Neurospora crassa as part of the cellular response to different types of membrane injury...Plasma membrane damage commonly occurs during cellular growth and development. To counteract these potentially lethal injuries, membrane repair mechanisms have evolved, which promote the integrity of the lipid bilayer. Although the membrane of fungi is the target of important clinical drugs and agricultural fungicides, the molecular mechanisms which mediate membrane repair in these organisms remain elusive. Here we identify the penta-EF-hand protein PEF1 of the genetic model fungus Neurospora crassa as part of a cellular response mechanism against different types of membrane injury. Deletion of the pef1 gene in the wild type and different lysis-prone gene knockout mutants revealed a function of the protein in maintaining cell integrity during cell–cell fusion and in the presence of pore-forming drugs, such as the plant defense compound tomatine. By fluorescence and live-cell imaging we show that green fluorescent protein (GFP)-tagged PEF1 accumulates at the sites of membrane injury in a Ca2+-dependent manner. Site-directed mutagenesis identified Ca2+-binding domains essential for the spatial dynamics and function of the protein. In addition, the subcellular localization of PEF1 revealed that the syncytial fungal colony undergoes compartmentation in response to antifungal treatment. We propose that plasma membrane repair in fungi constitutes an additional line of defense against membrane-disturbing drugs, thereby expanding the current model of fungal drug resistance mechanisms.
ARAH DAN KEBIJAKAN PERATURAN OTORITAS JASA KEUANGAN NOMOR 15/POJK.04/2015 TENTANG PENERAPAN PRINSIP SYARIAH DI PASAR MODAL
Authors: Suhendar Heris 
Published: July 2019

AbstrakSejak tahun 1997, pasar modal syariah Indonesia terus tumbuh dan berkembang yang ditandai dengan semakin banyaknya produk syariah, terbitnya regulasi terkait pasar modal syariah, dan semakin bertambah­nya masyarakat yang mengenal dan peduli pasar modal syariah. Peraturan terkait pasar modal syariah diterbitkan pertama kali pada tahun 2006, yaitu Peraturan No. IX.A.13 tentang Penerbitan Efek Syariah dan Peraturan No. IX.A.14 tentang Akad-akad yang Digunakan dalam Penerbitan Efek. Selanjutnya pada tahun 2007 diterbitkan Peraturan No. II.K.1 tentang Kriteria dan Penerbitan Daftar Efek Syariah. Seluruh peraturan tersebut memuat ketentuan khusus terkait dengan peme­nuhan prinsip syariah di pasar modal yang diadopsi dari fatwa Dewan Syariah Nasional (DSN). Kemudian pada tahun 2015, Otoritas Jasa Keuangan mengeluarkan Peraturan Nomor 15/POJK.04/2015 terkait dengan Penerapan Prinsip Syariah di Pasar Modal. Peraturan OJK tersebut mengarah kepada: 1) penguatan kerangka hukum untuk penerbitan efek syariah; 2) mengupayakan insentif untuk produk syariah; 3) memperkuat peran pelaku pasar di pasar modal syariah; dan 4) memperkuat landasan hukum bagi transaksi efek syariah. Pada saat Peraturan Otoritas Jasa Keuangan ini mulai berlaku, angka 1 Peraturan Nomor IX.A.13 tentang Penerbitan Efek Syariah, Lampiran Keputusan Ketua Badan Pengawas Pasar Modal dan Lembaga Keuangan Nomor: Kep-181/BL/2009 tanggal 30 Juni 2009 tentang Penerbitan Efek Syariah dicabut dan dinyatakan tidak berlaku.
PENGARUH CAR, NPF, DAN FDR TERHADAP ROA BANK MEGA SYARI’AH PERIODE MARET 2007 – DESEMBER 2014
Authors: Mudzakir Ahmad 
Published: July 2019

AbstrakPenelitian ini ditujukan untuk mengetahui pengaruh Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), dan Financing to Defosit Ratio (FDR) terhadap Return On Asset (ROA) baik secara parsial maupun simultan pada Bank Mega Syariah. Populasi dalam penelitian ini adalah rasio keuangan Bank Mega Syariah. Data sampel adalah rasio CAR, NPF, FDR, dan ROA yang diambil dari laporan keuangan triwulanan yang dipublikasikan pada situs resmi Otoritas Jasa Keuangan periode Maret 2007 sampai Desember 2014. Penelitian ini menggunakan metode deskriptif dan verifikatif. Teknik analisis menggunakan regresi linear berganda dengan terlebih dahulu melakukan uji asumsi klasik seperti uji normalitas, heteroskedastisitas, multikolinearitas dan autokorelasi. Hasil penelitian menunjukan bahwa secara parsial CAR berpengaruh negatif dan signifikan terhadap ROA, NPF berpengaruh negatif tapi tidak signifikan terhadap ROA, sementara FDR berpengaruh positif tapi tidak signifikan terhadap ROA. Secara simultan CAR, NPF dan FDR ber­pengaruh signifikan terhadap ROA.
Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness
Authors: Wang Chun-I , Kao Huang-Kai , Chen Ting-Wen , Huang Yenlin , Cheng Hsing-Wen , Yi Jui-Shan , Hung Shao-Yu , Wu Chi-Sheng , Lee Yun-Shien , Chang Kai-Ping 
Published: July 2019

AbstractBackgroundDNA copy number variations (CNVs) are a hallmark of cancer, and the current study aimed to demonstrate the profile of the CNVs for oral cavity squamous cell carcinoma (OSCC) and elucidate the clinicopathological associations and molecular mechanisms of a potential marker derived from CNVs, mixed-lineage leukemia translocated to chromosome 3 protein (MLLT3), in OSCC carcinogenesis.Materials and MethodsCNVs in 37 OSCC tissue specimens were analyzed using a high-resolution microarray, the OncoScan array. Gene expression was analyzed by real-time polymerase chain reaction in 127 OSCC and normal tissue samples. Cell function assays included cell cycle, migration, invasion and chromatin immunoprecipitation assays.ResultsWe found a novel copy number amplified region, chromosome 9p, encompassing MLLT3 via the comparison of our data set with six other OSCC genome-wide CNV data sets. MLLT3 overexpression was associated with poorer overall survival in patients with OSCC (p = .048). MLLT3 knockdown reduced cell migration and invasion. The reduced invasion ability in MLLT3-knockdown cells was rescued with double knockdown of MLLT3 and CBP/p300-interacting transactivator with ED rich carboxy-terminal domain 4 (CITED4; 21.0% vs. 61.5%). Knockdown of MLLT3 impaired disruptor of telomeric silencing-1-like (Dot1L)-associated hypermethylation in the promoter of the tumor suppressor, CITED4 (p &lt; .001), and hence dysregulated HIF-1α-mediated genes (TWIST, MMP1, MMP2, VIM, and CDH1) in OSCC cells.ConclusionWe identified unique CNVs in tumors of Taiwanese patients with OSCC. Notably, MLLT3 overexpression is related to the poorer prognosis of patients with OSCC and is required for Dot1L-mediated transcriptional repression of CITED4, leading to dysregulation of HIF-1α-mediated genes.Implications for PracticeThis article reports unique copy number variations in oral cavity squamous cell carcinoma (OSCC) tumors of Taiwanese patients. Notably, MLLT3 overexpression is related to the poorer prognosis of patients with OSCC and is required for Dot1L-mediated transcriptional repression of CITED4, leading to dysregulation of HIF-1α-mediated genes.