bluuebunny/crossref_metadata_2025_split huggingface dataset:
Androgenic Effects on Ventricular Repolarization
Authors: Salem Joe-Elie , Yang Tao , Moslehi Javid J. , Waintraub Xavier , Gandjbakhch Estelle , Bachelot Anne , Hidden-Lucet Francoise , Hulot Jean-Sebastien , Knollmann Bjorn C. , Lebrun-Vignes Benedicte , Funck-Brentano Christian , Glazer Andrew M. , Roden Dan M. 
Published: August 2019

Background:
Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking.

Methods:
We searched the international pharmacovigilance database VigiBase for men (n=6 560 565 individual case safety reports) presenting with aLQTS, TdP, or sudden death associated with ADT. In cardiomyocytes derived from induced pluripotent stem cells from men, we studied electrophysiological effects of ADT and dihydrotestosterone.

Results:

Among subjects receiving ADT in VigiBase, we identified 184 cases of aLQTS (n=168) and/or TdP (n=68; 11% fatal), and 99 with sudden death. Of the 10 ADT drugs examined, 7 had a disproportional association (reporting odds ratio=1.4–4.7;
P
<0.05) with aLQTS, TdP, or sudden death. The minimum and median times to sudden death were 0.25 and 92 days, respectively. The androgen receptor antagonist enzalutamide was associated with more deaths (5430/31 896 [17%];
P
<0.0001) than other ADT used for prostate cancer (4208/52 089 [8.1%]). In induced pluripotent stem cells, acute and chronic enzalutamide (25 µM) significantly prolonged action potential durations (action potential duration at 90% when paced at 0.5 Hz; 429.7±27.1 (control) versus 982.4±33.2 (acute,
P
<0.001) and 1062.3±28.9 ms (chronic;
P
<0.001), and generated afterdepolarizations and/or triggered activity in drug-treated cells (11/20 acutely and 8/15 chronically). Enzalutamide acutely and chronically inhibited delayed rectifier potassium current, and chronically enhanced late sodium current. Dihydrotestosterone (30 nM) reversed enzalutamide electrophysiological effects on induced pluripotent stem cells.

Conclusions:
QT prolongation and TdP are a risk in men receiving enzalutamide and other ADTs.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03193138.
On the status of Suifunema peregrinatum (Carreno, 2017) n. comb. (Nematoda: Oxyuridomorpha: Thelastomatidae) and first record of the species for Japan
Authors: MORFFE JANS , CARRENO RAMON A. , OZAWA SOTA , SRIWATI RINA , HASEGAWA KOICHI 
Published: August 2019

Blattophila peregrinata Carreno, 2017 (Nematoda: Oxyuridomorpha: Thelastomatidae) is proposed as a junior synonym of Suifunema peregrinatum (Carreno, 2017) n. comb., based on the revision of the type material of S. caudelli Chitwood, 1932, the type and only species of the genus. The revision permitted the emendation of some features of the original descriptions, namely the position of the nerve ring at level of the corpus instead the isthmus and the female genital tract didelphic-prodelphic instead didelphic-amphidelphic. The males of S. peregrinatum n. comb. are the only ones known for the genus. Thus, an amended generic diagnosis is given, including information on the males. Both S. peregrinatum n. comb. and S. caudelli differ by having a more slender body, a longer tail, and the vulva farther from the anterior end in the former. S. peregrinatum n. comb. is recorded for the first time from Pycnoscelus indicus Fabricius, 1775 (Blattodea: Blaberidae) from Japan. The specimens from Japan are morphologically consistent with other populations of the species from the USA and the Galapagos Islands of Ecuador. Only some morphometrics vary slightly, but these are within the range of the species. The phylogenetic position of the genus among the family Thelastomatidae is discussed, including sequences of the D2-D3 LSU rDNA of specimens from both the type population (Ohio, USA) and Japan.
Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4
Authors: Huang Lu , Ding Wei , Wang Ming-Qiang , Wang Zheng-Gen , Chen Hong-Hui , Chen Wen , Yang Qiong , Lu Ting-Na , Yang Qing , He Ji-Man 
Published: August 2019

Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD). Methods Adult male Sprague Dawley rats were randomized into one of three groups: regular rat diet (CON group) for 4 months; high-fat diet (HFD group) for 4 months; HFD for 2 months followed by tanshinone IIA treatment plus HFD (TAN group) for a further 2 months. A range of physical and biochemical markers of lipid accumulation and fatty liver disease were measured and compared between the groups. Results Tanshinone IIA treatment significantly reduced fat accumulation in the liver and plasma lipid levels that had been increased by HFD. The toll-like receptor (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway was silenced by tanshinone IIA treatment. Tumour necrosis factor-α and interleukin-6 were reduced by tanshinone IIA. Hepatocyte apoptosis was inhibited by tanshinone IIA. Tanshinone IIA upregulated peroxisome proliferator-activated receptor gamma (PPAR-γ), which resulted in an improvement in the oxidative status. Conclusion Tanshinone IIA ameliorates NAFLD by targeting PPAR-γ and TLR4, resulting in decreased plasma lipids and oxidative stress, suggesting this strategy may form the basis of novel NAFLD therapies.
Double-pedicle propeller flap for reconstruction of the foot and ankle: anatomical study and clinical applications
Authors: Zheng Jianxiong , Liao Hua , Li Jie , Zhuo Lingjian , Ren Gaohong , Zhang Ping , Hu Jijie 
Published: August 2019

Objective Reconstruction of soft tissue defects in the foot and ankle remains challenging. This study was performed to investigate the technical points and clinical effects of a double-pedicle propeller flap for repair of foot and ankle soft tissue defects. Methods We used five fresh calf specimens to investigate the anatomical and operative aspects of a double-pedicle propeller flap. Eighteen patients with soft tissue defects in the foot and ankle subsequently underwent defect repair with double-pedicle propeller flaps. Results The anatomical study showed that the peroneal artery perforators and the sural nerve bundle (two blood supply systems) provided the theoretical anatomical basis for the double-pedicle propeller flap. The relative positions of the peroneal artery perforators and the sural nerve bundle differ according to the peroneal artery perforating level. Flap rotation in different directions can reduce or prevent the pedicles from compressing each other. All flaps survived, and three flaps developed local epidermal necrosis at the proximal end; these flaps healed after 1 to 2 weeks of dressing changes. The other 15 patients healed well. Conclusions The double-pedicle propeller flap can enhance the blood supply and venous return in the “big paddle” region of the flap, reducing the distal necrosis rate.
Wage–Productivity Relationship in Indian Manufacturing Industries: Evidences from State-level Panel Data
Authors: Jain Hansa 
Published: August 2019

Indian manufacturing industries have experienced the major effects of economic reforms. Since the effect of any policy is ultimately transferred to workers, this article is an attempt to determine the extent to which labour productivity and wages are inter-related in manufacturing industries. The study uses state-level panel data of manufacturing industries and empirically tests the relevance of marginal productivity theory of wages and efficiency wage theory. After confirming the stationarity of the series, various empirical tests such as cointegration, vector error correction mechanism and Granger causality are applied to check the long-run equilibrium relationship between wage growth and productivity growth. The study finds a divergence between wages and productivity in India as well as in the states. The empirical analysis confirms the existence of long-run relationship between the two variables and finds efficiency wage theory to be more appropriate as its long-term disequilibrium correcting process is quicker as compared to the marginal productivity theory. The study suggests for having a skill intensity matching with capital intensity. Appropriate level of skill and training among the workers will, on the one hand, increase their bargaining strength for more compensation, and on the other hand, will encourage them to produce more. JEL: J31, J24, O30, F66, L66
Preliminary Experience With Polyvinyl Alcohol Hydrogel Implant for Pathology of the Second Metatarsal Head
Authors: Glazebrook Mark , Morash Joel , Alhadhoud Meshal , Daniels Timothy R. 
Published: August 2019

Background: There is no consensus regarding which surgical technique is most beneficial for pathology of the second metatarsophalangeal joint. We report the use of polyvinyl alcohol hydrogel synthetic cartilage implant hemiarthroplasty for pathology of the second metatarsal head that has failed nonoperative treatment and present 5 cases with a minimum 15 months of follow-up. Methods: The technique for synthetic cartilage hemiarthroplasty of the second metatarsal head is described. The postoperative protocol included weightbearing as tolerated for 2 weeks and moderate limitations in activities of daily living to respect wound healing, followed by physiotherapy for range of motion exercises. Charts for patients who underwent this procedure between 2015 and 2017 were retrospectively reviewed. Outcome measures collected postoperatively included a pain visual analog scale, Short-Form 36 (SF-36) Physical Component Summary (PCS) and Mental Component Summary (MCS) scores, and Foot and Ankle Ability Measure (FAAM) Sports and Activities of Daily Living (ADL) current level of function percentages. Results: At 15 to 38 months of follow-up, patients reported little to no pain and good range of motion, with no complications. Mean outcome measure scores were 89 for FAAM ADL, 75 for FAAM Sports, 44.4 for SF-36 PCS, and 52.1 for SF-36 MCS. Conclusion: This preliminary study of synthetic cartilage hemiarthroplasty for treatment of joint-destructive conditions of the second metatarsal head demonstrated good outcomes and no complications in 5 cases at a mean 25 months of follow-up. Large prospective cohort studies are needed to prove the efficacy and safety of this new surgical technique for the treatment of pathology of the second metatarsal head. Level of Evidence: Level IV, retrospective case series.
Early cannulation of the Hemodialysis Reliable Outflow graft
Authors: Vowels Travis J , Mohamed Ahmed , Bennett Matthew E , Peden Eric K 
Published: August 2019

Objective: In complex dialysis patients, central venous stenosis may preclude additional upper extremity access options. The Hemodialysis Reliable Outflow graft (Merit Medical Systems, Inc.) can bypass this stenosis providing patients with an additional upper extremity long-term access option. We report our experience with early-cannulation Hemodialysis Reliable Outflow grafts and compare them to traditional Hemodialysis Reliable Outflow grafts. Methods: We retrospectively reviewed all patients undergoing Hemodialysis Reliable Outflow graft placement from 1 January 2013 through 15 August 2017 at our institution and compared those undergoing placement of traditional Hemodialysis Reliable Outflow grafts and simultaneous tunneled dialysis catheter insertion to those undergoing Hemodialysis Reliable Outflow graft placement using an early-cannulation Hemodialysis Reliable Outflow graft without a tunneled dialysis catheter. Results: A total of 88 patients had 98 Hemodialysis Reliable Outflow grafts inserted throughout this time period. Of these, 61 (62%) were early-cannulation Hemodialysis Reliable Outflow grafts, while 37 (38%) were traditional Hemodialysis Reliable Outflow grafts. Primary, primary-assisted, and secondary patency rates at 1 year were higher for the traditional Hemodialysis Reliable Outflow graft cohort (53.1% vs 25.2%, p < 0.01; 70.1% vs 30.5%, p < 0.01; and 80.4% vs 55.4%, p = 0.07, respectively). There was no difference in the rate of postoperative hematoma, seroma, pseudoaneurysm formation, steal syndrome, or overall graft thrombosis between the two cohorts. Early-cannulation Hemodialysis Reliable Outflow grafts required earlier reintervention for thrombosis and earlier reintervention for any cause when compared to traditional Hemodialysis Reliable Outflow grafts (146 ± 184 days vs 417 ± 272 days, p < 0.01, and 123 ± 169 days vs 401 ± 311 days, p < 0.01, respectively). Conclusion: In complex dialysis patients, early-cannulation Hemodialysis Reliable Outflow grafts have significantly lower 1-year primary and primary-assisted patency rates and require earlier reintervention to maintain this patency compared to traditional Hemodialysis Reliable Outflow grafts.
Results from a meta-analysis of immune checkpoint inhibitors in first-line renal cancer patients: does PD-L1 matter?
Authors: Roviello Giandomenico , Corona Silvia Paola , Nesi Gabriella , Mini Enrico 
Published: August 2019

Background: The aim of this study was to perform a literature-based meta-analysis to assess the efficacy of the novel immune checkpoint inhibitors (ICIs) in first-line metastatic renal cell carcinoma (RCC), focusing on the predictive role of PD-L1 expression. Methods: The primary outcome was overall survival, and secondary outcomes were progression-free survival (PFS) and objective response. We planned a subgroup analysis for overall survival according to PD-L1 status. Results: Five studies were included in the analysis for a total of 4063 cases. Overall survival was greater in PD-L1 positive tumours (HR = 0.49, 95% CI: 0.36–0.67; p < 0.001). The pooled analysis of the unselected cases showed a statistically significative improvement in PFS with the use of ICIs (HR = 0.85, 95% CI: 0.72–0.99; p = 0.04) and we found a greater PFS benefit (HR = 0.65, 95% CI: 0.57–0.74; p < 0.001) in patients with PD-L1 positive tumours. Conclusions: This study supports the efficacy of ICIs and, although a significant clinical benefit has been reported in PD-L1 negative patients, a greater efficacy of ICIs was observed in PD-L1 positive patients. More prospective randomized studies are needed to clarify the role of PDL-1 status in metastatic RCC treated with ICIs.
Effects of knee orthoses on kinesthetic awareness and balance in healthy individuals
Authors: Ramstrand Nerrolyn , Gjøvaag Terje , Starholm Inger Marie , Rusaw David F 
Published: August 2019

Introduction Conflicting evidence exists regarding the effects of knee orthoses on proprioception. One belief is that pressure applied by orthoses heightens kinesthetic awareness and that this affects balance. This study aimed to investigate the effects of two different orthosis designs on kinesthetic awareness and balance in healthy individuals. Methods Twenty individuals (13 women) participated in this case series study. Each was tested wearing 1/no orthosis, 2/soft elastic orthosis and 3/non-elastic jointed orthosis. Pressure under orthoses was recorded. Kinesthetic awareness was investigated by testing joint position sense and threshold to detection of passive motion. Balance was tested using a modified sensory organization test. Results Non-elastic jointed orthoses applied the greatest pressure to the knee. With non-elastic jointed orthoses, threshold to detection of passive motion was significantly poorer for pooled results ( p = 0.02) and when the start position of the knee was 70° (mean threshold = 0.6°, 0.6°, 0.7° for no-orthosis, elastic and jointed-orthoses; p = 0.03). No major differences were observed in JPS or balance and correlation between proprioception and balance was poor. Conclusions There may be a limit to the amount of pressure that should be applied to the knee joint by an orthosis. Exceeding this limit may compromise kinesthetic awareness.
Understanding the interactions between iron supplementation, infectious disease and adverse birth outcomes is essential to guide public health recommendations
Authors: Fowkes Freya J. I. , Davidson Eliza , Agius Paul A. , Beeson James G. 
Published: August 2019

AbstractPregnant women are highly susceptible to anaemia and iron deficiency due to the increased demands of pregnancy as well as other factors. Iron supplementation is recommended in pregnancy, yet the benefits on newborn outcomes are variable between populations, most likely due to the heterogeneity in the prevalence of iron deficiency, detrimental birth outcomes and infectious diseases. Furthermore, there are concerns regarding iron supplementation in malaria-endemic areas due to reports of increased risk of malaria in those receiving iron. This is compounded by limited knowledge of how iron deficiency, anaemia, malaria, and other infections may interact to influence birth outcomes. In a recent cohort study in Papua New Guinea, where there is a high burden of infections and iron deficiency, we found that iron deficiency in pregnancy was associated with a reduced risk of adverse birth outcomes. However, this effect could not be wholly explained by interactions between iron deficiency and malaria. We proposed that iron deficiency may confer a degree of protection against other infectious pathogens, which in turn caused improvements in birthweight. We argue that further studies in multiple populations are crucial to elucidate interactions between iron status, iron supplementation and birthweight as well as to understand the context-specific benefits of iron supplementation in pregnancy and inform public policy. Focus should be given to haematological studies on anaemia, haemodilution and iron absorption, as well as investigating infectious diseases and other nutritional deficiencies. This is a particular priority in resource-constrained settings where the prevalence of iron deficiency, poor nutrition, infections and poor birth outcomes are high. While current recommendations of iron supplementation and malaria prophylaxis to reduce the burden of poor pregnancy outcomes should be supported, the strength of evidence underpinning these must be improved and new insights should be garnered in order to maximise improvements in maternal and child health.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1146-z.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1375-9.
A longitudinal study of eating behaviours in childhood and later eating disorder behaviours and diagnoses
Authors: Herle Moritz , Stavola Bianca De , Hübel Christopher , Abdulkadir Mohamed , Ferreira Diana Santos , Loos Ruth J. F. , Bryant-Waugh Rachel , Bulik Cynthia M. , Micali Nadia 
Published: August 2019

BackgroundEating behaviours in childhood are considered as risk factors for eating disorder behaviours and diagnoses in adolescence. However, few longitudinal studies have examined this association.AimsWe investigated associations between childhood eating behaviours during the first ten years of life and eating disorder behaviours (binge eating, purging, fasting and excessive exercise) and diagnoses (anorexia nervosa, binge eating disorder, purging disorder and bulimia nervosa) at 16 years.MethodData on 4760 participants from the Avon Longitudinal Study of Parents and Children were included. Longitudinal trajectories of parent-rated childhood eating behaviours (8 time points, 1.3–9 years) were derived by latent class growth analyses. Eating disorder diagnoses were derived from self-reported, parent-reported and objectively measured anthropometric data at age 16 years. We estimated associations between childhood eating behaviours and eating disorder behaviours and diagnoses, using multivariable logistic regression models.ResultsChildhood overeating was associated with increased risk of adolescent binge eating (risk difference, 7%; 95% CI 2 to 12) and binge eating disorder (risk difference, 1%; 95% CI 0.2 to 3). Persistent undereating was associated with higher anorexia nervosa risk in adolescent girls only (risk difference, 6%; 95% CI, 0 to 12). Persistent fussy eating was associated with greater anorexia nervosa risk (risk difference, 2%; 95% CI 0 to 4).ConclusionsOur results suggest continuities of eating behaviours into eating disorders from early life to adolescence. It remains to be determined whether childhood eating behaviours are an early manifestation of a specific phenotype or whether the mechanisms underlying this continuity are more complex. Findings have the potential to inform preventative strategies for eating disorders.
Crafting Innovation, Weaving Sustainability
Authors: Mamidipudi Annapurna 
Published: August 2019

Abstract
Handloom weaving in India is a vibrant and dynamic craft-based technology that is more than two thousand years old. It is the second-largest provider of rural livelihoods, with a 10 percent share of the domestic textile market, unified under the cultural brand of “handloom.” Yet weavers, like other craftspeople in India, stand in the shadow of deep divisions: rich/poor, urban/rural, modern/traditional, Brahmin/Dalit, educated scientist/illiterate laborer. As a system of knowledge, handloom weaving is associated with a museumized past rather than a promising future; the weaver is seen as a laboring body rather than an innovative mind. Yet through theorizing handloom weaving as sociotechnology, this essay endeavors to explicate the sustainability and innovation in handloom weaving. Studying examples of innovation in handloom weavers, the essay explores craft livelihoods as offering the opportunity for political action: as a unifying device for cultural cohesion, as embodied knowledge that engages both mind and body, and as a tool for justice and equity.
Professions of Friendship
Authors: Tambar Kabir 
Published: August 2019

Abstract
This essay examines “professions of friendship”: efforts by populations who are targeted as enemies of the state to proclaim their historical fidelity to the state's foundation and preservation. Such declarations often reinscribe a rigid and often violently statist narrative of politics. The essay argues that the retrenchment of this narrative, when reissued in the name of friendship, does not simply close down political options. It seeks to embolden sentiments of moral obligation across instituted lines of enmity. These solicitations of friendship are burdened by a particular historical task: to envision a past and a future of social cohabitation in a present where its possibilities have been violently undermined and morally devalued. The essay centers on two instances that bookend the past century: the first was delivered in Istanbul by an organization speaking on behalf of Armenians living in territories claimed by the Turkish nationalist movement in 1922; the second was issued by a Kurdish Peace Mother in Diyarbakır, as a plea for an end to state violence in late 2015.