bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Single-Arm, Phase II Study of Apatinib in Refractory Metastatic Colorectal Cancer
Authors: Chen Xiaofeng , Qiu Tianzhu , Zhu Yingwei , Sun Jing , Li Ping , Wang Biao , Lin Peinan , Cai Xiaomin , Han Xiao , Zhao Fengjiao , Shu Yongqian , Chang Lianpeng , Jiang Hua , Gu Yanhong 
Published: March 2019

Abstract

Lessons Learned
Patients with metastatic colorectal cancer with good performance status or no liver metastasis could benefit from apatinib. Circulating tumor DNA abundance may be a predictor in serial monitoring of tumor load.

Background
Apatinib, an oral vascular endothelial growth factor (VEGF) receptor-2 inhibitor, has been approved as third-line treatment for metastatic gastric cancer in China. The aim of this study was to evaluate the efficacy and safety of apatinib, in the treatment of patients with refractory metastatic colorectal cancer after failure of two or more lines of chemotherapy.

Methods
In this open-label, single-arm, phase II study, patients with histological documentation of adenocarcinoma of the colon or rectum were eligible if they had received at least two prior regimens of standard therapies including fluoropyrimidine, oxaliplatin, and irinotecan. These patients were treated with apatinib in a daily dose of 500 mg, p.o., in the third-line or higher setting. Capture sequencing was dynamically performed to identify somatic variants in circulating tumor DNA (ctDNA) with a panel of 1,021 cancer-related genes. The primary endpoint was progression-free survival (PFS) and the tumor response was determined according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Interim analysis was applied as predefined.

Results
From June 1, 2016 to December 31, 2017, 26 patients were enrolled. The median PFS of the whole group was 3.9 months (95% confidence interval [CI]: 2.1–5.9). The median overall survival (OS) was 7.9 months (95% CI: 4.6–10.1+). Patients with performance status (PS) 0–1 had longer PFS than those with PS 2 (4.17 months vs. 1.93 months, p = .0014). Patients without liver metastasis also had longer PFS than those who had live metastasis (5.87 months vs. 3.33 months, p = .0274). The common side effects of apatinib were hypertension, hand-foot syndrome, proteinuria, and diarrhea. The incidence of grade 3–4 hypertension, hand-foot syndrome, proteinuria, and diarrhea was 76.92%, 11.54%, 73.08%, and 23.08%, respectively. All of the patients received dose reduction because of adverse effect. Results of capture sequencing showed APC, TP53, and KRAS were most frequently mutant genes. c?tDNA abundance increased before the radiographic assessment in ten patients.

Conclusion
Apatinib monotherapy showed promising efficiency for patients with refractory colorectal cancer, especially in patients with PS 0–1 or no liver metastasis. ctDNA abundance may be a predictor in serial monitoring of tumor load.
Perilaku Elektrokimia Baja Tahan Karat SS 316 Dalam Media Nano Fluida
Authors: Hadi Prajitno Djoko , Setiawan Jan 
Published: March 2019

PERILAKU ELEKTROKIMIA BAJA TAHAN KARAT SS 316 DALAM MEDIA NANO FLUIDA. Korosi merupakan permasalahan umum yang sering terjadi pada logam dan paduannya. Metode pengujian secara elektrokimia merupakan salah satu metode yang tepat untuk mempelajari korosi logam dan paduannya dalam lingkungan tertentu. Pada penelitian ini dilakukan evaluasi baja tahan karat SS 316 dalam media air demin dan nano fluida yang mengandung partikel nano ZrO2 dengan metode elektrokimia. Potensial korosi, polarisasi Tafel, dan Electrochemical Impedance Spectroscopy (EIS) digunakan untuk mempelajari perilaku elektrokimia baja tahan karat SS 316 dalam media air demin dan nano fluida dengan variasi waktu perendaman selama 10, 60 dan 120 menit. Hasil pengukuran terhadap potensial korosi baja tahan karat SS 316 dalam media air demin dan nanofluid menunjukkan peningkatan seiring dengan bertambahnya waktu perendaman. Hasil pengukuran konstanta Tafel anodik pada baja tahan karat SS 316 dalam media air demin dan nano fluida menunjukkan bahwa nilai konstanta Tafel naik dengan dengan bertambahnya waktu perendaman. Hasil analisis polarisasi Tafel ditunjukkan bahwa laju korosi baja tahan karat SS 316 dalam media air demin dan nanofluid tidak terlihat perbedaan yang berarti dan laju korosi cenderung turun seiring dengan bertambahnya waktu perendaman. Hasil analsis dengan EIS pada baja tahan karat SS 316 menunjukkan bahwa nilai impedance yang tinggi dalam media nano fluida sehingga memiliki laju korosi yang rendah bila dibandingkan dalam media air demin. Analisis dengan difraksi sinar X (X-RD) menunjukkan bahwa fasa utama pada baja tahan karat SS 316 hasil pengujian korosi dalam media air demin dan nano fluida adalah γ-austenit. Baja tahan karat SS 316 mempunyai ketahanan korosi yang tinggi dalam media air demin dan nano fluida dengan laju korosi di bawah 1 MPY.Kata kunci: SS 316, korosi, ZrO2, nano fluida, metode EIS
KALIMAT DALAM SISINDIRAN DAN WAWANGSALAN ANYAR KARYA DÉDY WINDYAGIRI (Kajian Struktur dan Semantik)
Authors: SUMARNI HENA 
Published: March 2019

Penelitian ini bertujuan untuk mendeskripsikan kalimat dalam sisindiran dan wawangsalan anyar. Dalam penelitian ini digunakan metode deskriptif. Untuk mengumpulkan data digunakan teknik studi pustaka. Pengolahan data dilakukan dengan menggunakan metode distribusional dengan téknik analisis unsur langsung yang diikuti oleh teknik ekspansi, permutasi dan delisi. Temuan-temuan dalam penelitian ini adalah déskripsi tentang bentuk kalimat dalam sisindiran dan wawangsalan yang berupa kalimat majemuk dengan tipe dan pola kalimat yang variatif, hubungan makna antraklausa dalam kalimat majemuk serta kekhasan-kekhasan kalimat dalam sisindiran dan wawangsalan anyar, yakni (1) bentuk kalimat berupa kalimat majemuk, (2) memiliki kebebasan dalam konstruksi (struktur) kalimat, (3) kelonggaran gaya dalam menempatkan urutan kata, dan (4) subyek sering tidak dikatakan.AbtsractThis study aimed to describe the sentences in the text of sisindiran and wawangsalan anyar. The research used descriptive methods. The data collection of this study employed the techniques of literature study. The data processing was distributional method with direct elemental analysis techniques. This was followed by the techniques of expansion, permutation, and deletion. The research findings cover description of the sentence forms in sisindiran and wawangsalan. They are complex sentences containing various sentence patterns and types and meaning relations between clauses in compound sentences. It also contains peculiarities of sentence. The peculiarities are (1) the form of complex sentences, (2) the freedom in construction (structure) of sentences, (3) the flexibility of word order, and (4) the hidden subject.
RABAB PASISIA SELATAN DI MINANGKABAU DI AMBANG KEPUNAHANNYA
Authors: Rosa Silvia 
Published: March 2019

Barabab adalah suatu bentuk pertunjukan seni tradisi yang menyampaikan cerita kaba oleh seorang atau dua orang penampil dengan diiringi oleh permainan alat musik rabab (semacam alat musik gesek yang mirip biola). Pertunjukan Barabab berlangsung semalam suntuk. Biasanya pertunjukkan Barabab dihadirkan sebagai salah satu bentuk bungo alek (hiasan keramaian) dalam sebuah acara, baik perkawinan, perayaan atau peresmian peristiwa-peristiwa penting dalam masyarakat adat di Minangkabau. Permasalahannya kini adalah realitas pewarisan seni pertunjukkan Barabab, Pewarisan aktif keterampilan mempertunjukkan seni tradisi Barabab tidak berlangsung baik dan berkesinambungan dari si pewaris aktif kepada generasi berikutnya.Penampil Barabab adalah pria-pria tua yang sudah berumur di atas 55 tahun dan atau lebih. Lalu bagaimana bila pewarisan tidak berlangsung lurus secara berkesinambungan dari generasi tua kepada generasi muda berikutnya. Tentu saja seni tradisi Barabab akan tinggal kenangan dan nama saja, berganti dengan corak musik Barat yang cenderung lebih diminati oleh generasi muda kini, misalnya organ tunggal dan sejenisnya. Kerisauan akan kepunahan seni tradisi Barabab ini sudah patut direncanakan tindakan penyelamatannya. Salah satu upayanya adalah dengan mencanangkan secara aktif untuk belajar budaya, khususnya belajar seni tradisi pertunjukan Barabab yang telah menjadi ikon seni pertunjukan penting di Pesisir Selatan.Upaya ini penting dilakukan secara terorganisir antara pemerhati budaya (perguruan tinggi) dengan Pemerintah Daerah Pesisir Selatan. Kebijakan-kebijakan pemerintah untuk membangun ruang atau tempat untuk belajar budaya, terutama seni Barabab, tindakan urgen untuk dirintis dan dikembangkan ke depan, dan sejak kini.ABSTRACT Barabab is a form of traditional art performances that convey kaba story by one or two performers that are accompanied by rabab musical instrument (a kind of stringed instrument similar to a violin). The Barabab show lasted all night long. Usually Barabab shows are presented as a form of bungo alek (ornament of the crowd) in an event, whether marriage ceremony, celebration or inauguration of important events in indigenous peoples in Minangkabau. In the reality there is problem that Barabab active inheritance of Barabab's performing arts skills does not go well and sustain from the active performers to other generation. Barabab performers are old men over the age of 55. If the inheritance is not sustainable from older generation to other generation, the Barabab tradition will be extinct. One of the efforts to actively promote the learning of culture, especially learning the art of tradition of Barabab show which has become an icon of important performing arts in South Coastal of Minangkabau. The effort is important to be done in an organized manner between cultural observers (universities) and the South Coastal Government. There is a crusial needs of government decision and policies to build space or place to learn culture, especially Barabab art.
MANFAAT EKONOMIS TEKNOLOGI INFORMASI (TI) DALAM IMPLEMENTASI SISTEM RESI GUDANG (SRG) DAN PASAR LELANG KOMODITI (PLK) SEKTOR PERTANIAN
Authors: Andriariza Yan , Anandhita Vidyantina Heppy , Sirait Emyana Ruth Erita , Hernikawati Dewi , Wildana Faiq , Dunan Amri , Mustika Rieka 
Published: March 2019

AbstractThe integration of internet-based Warehouse Receipt System (SRG) and Commodity Auction Market (PLK) is expected to be an alternative to resolve the problems faced by most farmers in Indonesia, so through this research we want to identify the economic benefits obtained by stakeholders of SRG and PLK. This study uses mixed method, with primary data collection techniques through interviews with selected informants. The results of this study show some of main benefits for stakeholders, where the main benefit for farmers is increasing income because it expands market segmentation. AbstrakIntegrasi Sistem Resi Gudang (SRG) dan Sistem Pasar Lelang Komoditas (PLK) yang berbasis internet diharapkan dapat menjadi salah satu alternatif untuk menyelesaikan permasalahan yang dihadapi sebagian besar petani di Indonesia, maka melalui penelitian ini ingin mengidentifikasi manfaat ekonomis yang didapatkan oleh para stakeholders SRG dan PLK. Penelitian ini menggunakan metode penelitian mixed method, dengan teknik pengumpulan data primer dilakukan melalui wawancara dengan informan terpilih. Hasil dari penelitian ini adalah diketahuinya beberapa manfaat utama bagi para stakeholdernya, dimana manfaat utama bagi Petani sendiri adalah meningkatkan pendapatan karena memperluas segmentasi pasar.
DENİZ HUKUKUNA İLİŞKİN TEMEL EGEMENLİK ALANLARI BAĞLAMINDA ARKTİK’TEKİ İHTİLAFLI ALANLAR VE HUKUKİ DURUM
Authors: SANCAK Kadir 
Published: March 2019

Dünyada sorunların ve ihtilafların bulunduğu birçok bölge vardır
ve bunlardan biri de Arktik’tir. Coğrafi şartlarının elverişsiz olması bölgeyi
yakın dönemlere kadar küresel güçlerin hegemonik paylaşımlarından uzak
tutmuştur. Ancak teknolojik gelişmelere ilave olarak iklim değişiklikleri gibi
çevresel faktörler Arktik bölgesini küresel mücadelenin gündemine dâhil
etmiştir. Dünyada pay edilmeyen son coğrafyalardan olan Arktik, bugün özellikle
kıyıdaş beş ülkenin egemenlik iddiaları ile konuşulmaktadır. Bugün için Kuzey Kutbu’nun hukuki statüsünü
düzenleyen özel bir antlaşma ya da düzenleme bulunmamaktadır. Kıyıdaş ülkeler
bölgedeki anlaşmazlıkların çözümü için 1982 tarihli BMDHS’yi esas almaktadırlar.
Bölgedeki en önemli sorun kıyıdaş ülkelerin sahip oldukları kıta
sahanlıklarının sınırlarının belirlenmesi sorunudur. Bu bağlamda ABD dışındaki
dört ülke sahip oldukları 200 deniz millik kıta sahanlığını 350 deniz miline kadar genişletme
talebiyle Birleşmiş Milletler Kıta Sahanlığı Sınırları Komisyonu’na başvurmuş
ve başvurular henüz bir karara bağlanmamıştır. Bu çalışmada meselenin daha iyi
anlaşılabilmesi için öncelikli olarak deniz hukukuna ilişkin temel kavramlar
açıklanmıştır. Sonrasında ise meselenin esasını oluşturan bölgedeki ihtilaflı
alanlar ve bunların hukuki durumu izah edilmeye çalışılmıştır.
ФІНАНСОВО-ЕКОНОМІЧНІ АСПЕКТИ ЗАБЕЗПЕЧЕННЯ ЗРОСТАННЯ КАПІТАЛІЗАЦІЇ МАШИНОБУДІВНИХ ПІДПРИЄМСТВ УКРАЇНИ
Authors: Kryvoruchkina O. V. , Hmyria V. P. , Smirnov Ye. V. , Tepliuk M. A. 
Published: March 2019

Визначено основні наукові підходи до дослідження капіталізації (процесний, результатний, фінансовий, реляційний, ресурсний), у яких розкривається її складна економічна природа за сучасних умов функціонування та розвитку підприємства. Відповідно до авторської логіки визначення капіталізації процеси її оцінювання запропоновано здійснювати в єдності взаємозв’язку представлених підходів до її розуміння. Особливістю такого взаємозв’язку є те, що фінансовий, ресурсний, процесний і реляційні аспекти є формувальними відносно результатного. Наведено аргументацію доцільності використання фундаментальної вартості як критерію оцінювання результатних аспектів капіталізації підприємств. Обґрунтовано параметри вибору вартісної аналітичної моделі, до яких віднесено: наявність достовірної вихідної інформаційної бази, аналітичний потенціал факторної інтерпретації, рівень складності інтерпретації результатів. Представлено результати багатофакторного аналізу фундаментальної капіталізації машинобудівних підприємств України на основі моделі остаточного чистого прибутку (RE-моделі) і підтверджено дієвість, адекватність і практичну значущість обраного методичного підходу до оцінювання капіталізації як сукупного економічного результату діяльності підприємств. Найбільш інформативними факторами щодо рівня капіталізації підприємства визначено спред дохідності реалізації продукції, коефіцієнт відповідності фактичного рівня рентабельності продажу критичним значенням, продуктивність функціонування активів. Визначено причини спадних вартісних тенденцій капіталоутворення на українських машинобудівних підприємствах. Результати фундаментально-вартісного аналізу машинобудівних підприємств у ресурсному, реляційному і процесному аспектах дозволило дійти висновку щодо пріоритетного джерела забезпечення стійкості зростання капіталізації, яким визначено технологічну стратегію, що має бути реалізованою на засадах концепції «Індустрія 4.0». Представлено характеристику ймовірних ефектів від реалізації стратегії капіталоутворення відповідно до принципів концепції «Індустрія 4.0».
Women in Adult Education Program for Sustainable Development: Challenges and Implications for Library and Information Services
Authors: Osuchukwu Ngozi Perpetua , Nebolise Ndidiamaka Lucy 
Published: March 2019

Abstract
Objective – Education offers advances in human and social development. It provides knowledge and resources that hold the potential for economic empowerment, resulting in a better livelihood. Hence, women need access to education with library services, if they are to have a voice, participate in sustainable development, and take care of their own health, as well as that of their children and members of their households. This paper examines the challenges women encounter in Onitsha metropolis, Anambra State, Nigeria. This study seeks to gain insight into the resources used to enhance learning, as well as the students’ perceptions and satisfaction with their learning experience.
Methods – A descriptive survey research design was used. The study was carried out in five adult education centres in the city with a sample size of 120 women, randomly selected for collection of data. Questionnaire, interview, and observation methods were employed. The physical assessment of the centres was done for an evidence based report and to assess the real situations of the centres.
Results – The findings show the challenges faced by Nigerian women in their pursuit of ongoing adult education included: time for the classes which are usually held in the evening, poor financial status, lack of encouragement from spouses and relations, poor learning environments, and stress. The data were analyzed using percentages and frequency counts. They are presented in tables and figures.
Conclusions – It is recommended that education and library management should assess these centres for program improvements like providing more enabling environments and learning facilities. The implication of the study is that library and information services should be extended to these women to stimulate and support learning with the right attitude for active involvement in the educational activities and for enhancement of social inclusion.
El transporte fluvial: luces y sombras. Un análisis comparativo entre sistemas de transportes para cargas en la mesopotamia argentina en pos de la multimodalidad
Authors: Mateo José , Ferreyra Ana María 
Published: March 2019

RESUMENAsí como los metales son los mejores conductores del calor y de la electricidad, el agua lo es del comercio. Sin embargo, no siempre es posible utilizar este medio por razones obvias. Este no es el caso de la mesopotamia argentina que por definición se erige entre ríos. No obstante, el transporte fluvial es de los menos utilizados, aunque se encuentra en reciente crecimiento. El presente trabajo intenta una comparación entre tres sistemas de transporte (fluvial, ferroviario y automotor) en cinco indicadores: velocidad, costos operativos, seguridad, capacidad de carga y flexibilidad. Se concluye en la necesidad de un estudio exhaustivo que determine para la región el circuito multimodal más adecuado en tanto eficiencia y eficacia y qué cuota de sistema deberíarealizarse con cual modo de transporte.Palabras clave: transporte; multimodalidad; Argentina; Mesopotamia.River transport: Lights and shadows.A cross-modal analysis of freight transport systems for Argentina's Mesopotamia in the pursuit of Multimode.ABSTRACTJust as metals are the best conductors of heat and electricity, so is water from commerce. However, it is not always possible to use this medium for obvious reasons. This is not the case of the Argentine Mesopotamia which is, obviously, located between rivers. However, fluvial transport is one of the least used, although it is in recent growth. This paper attempts a comparison between three transport systems (fluvial, railway and automotive) in five indicators: speed, operating costs, safety, load capacity and flexibility. It is concluded in theneed for a thorough study that determines for the region the most suitable multimodal circuit in both efficiency and efficacy and what system quota should be made with which mode of transport.Keywords: transportation; multimodality; Argentina; MesopotamiaO transporte fluvial: luzes e sombras. Uma análise comparativa entre sistemas de transporte de cargas na mesopotâmia argentina em busca de a ultimodalidadeRESUMOAssim como os metais são os melhores condutores de calor e eletricidade, o mesmo acontece com a água e o comércio. No entanto, nem sempre é possível usar esse meio por razões óbvias. Este não é o caso da Mesopotâmia Argentina, que, por definição, fica entre os rios. Sim embargo, o transporte fluvial es uno de os menos utilizados, embora esteja em crescimento recente. Este artigo tenta uma comparação entre três sistemas de transporte (fluvial, ferroviário e automotivo) em cinco indicadores: velocidade, custos operacionais, segurança,capacidade de carga e flexibilidade. Conclui-se na necessidade de um estudo aprofundado que determine para a região o circuito multimodal mais adequado tanto na eficiência como na efetividade e a que quota de sistema deve ser feita com um modo de transporte determinado.Palavras-chave: transporte; multimodalidade; Argentina; Mesopotâmia.
Efficacy of intranasal dexmedetomidine for removal of inhaled foreign bodies in children by flexible fiberoptic bronchoscopy: a randomized, double-blind, placebo-controlled clinical trial
Authors: Wu Lan , Bi Yanmei , Ma Yushan , Ni Juan 
Published: March 2019

Abstract
Background: The traditional technique for foreign body removal is rigid bronchoscopy. However, fiberoptic bronchoscopy is becoming more popular for foreign body removal. Compared with rigid bronchoscopy, fiberoptic bronchoscopy is better suited for removing foreign bodies from the distal airways and upper lobe bronchi because of the smaller diameter and greater flexibility of the bronchoscope. Dexmedetomidine, a highly selective α2 adrenergic agonist, reduces preoperative anxiety, reduces the requirement for general anesthetics, and does not induce respiratory depression. The safety and efficacy of intravenous dexmedetomidine have been confirmed in patients undergoing fiberoptic bronchoscopy. Intranasal dexmedetomidine reportedly produce satisfactory sedation in children. We hypothesized that intranasal dexmedetomidine at 1 µg·kg−1 administered 25 minutes before anesthetic induction can reduce the incidence of adverse events during fiberoptic bronchoscopy under sevoflurane inhalation general anesthesia.
Methods: Forty preschool-aged children (6–48 months) with an American Society of Anesthesiologists physical status of I or II were randomly allocated to receive either intranasal dexmedetomidine at 1 µg·kg−1 or normal saline at 0.01 ml·kg−1 25 minutes before anesthetic induction. The primary outcome was the incidence of perioperative adverse events. The heart rate, respiratory rate, separation score, tolerance of the anesthetic mask, agitation score, anesthetic induction time, consumption of sevoflurane, and recovery time were also recorded.
Results: The incidence of laryngospasm, breath-holding, and coughing were significantly lower in patients who received intranasal dexmedetomidine than saline (15% vs. 50%, P=0.018; 10% vs. 40%, P=0.028; and 5% vs. 30%, P=0.037, respectively). Patients who received intranasal dexmedetomidine had a lower separation score (P=0.017), more satisfactory tolerance of the anesthetic mask (P=0.027), a significantly shorter anesthetic induction time (5.75±1.4 vs. 7.75±2.5 min, P=0.004), and less consumption of sevoflurane (38.18±14.95 vs. 48.03±14.45 ml, P=0.041). The recovery time was similar in both groups, and the frequency of postoperative agitation was significantly lower in patients who received intranasal dexmedetomidine (P=0.004).
Conclusions: Intranasal dexmedetomidine at 1 µg·kg−1 can reduce the incidence of laryngospasm, breath-holding, and coughing during fiberoptic bronchoscopy for foreign body removal via its sedative and analgesic effects. Moreover, intranasal dexmedetomidine can reduce postoperative agitation without a prolonged recovery time.