bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Gel Larval Diet With Traditional Lucerne Chaff and Carrot Solid Diets for Rearing of Queensland Fruit Fly (Diptera: Tephritidae)
Authors: Mainali Bishwo P , Moadeli Tahereh , Ponton Fleur , Taylor Phillip W 
Published: May 2019

AbstractSterile insect technique (SIT) for Queensland fruit fly, Bactrocera tryoni Froggatt, Australia’s most economically damaging fruit fly species, is currently undergoing a major renewal and expansion. SIT relies on efficient and economical mass-rearing procedures that produce high-quality flies. Two solid larval diets, carrot and lucerne chaff, have traditionally been used to rear Queensland fruit fly. Recently, a gel larval diet has been developed to eliminate biological bulking agents from the mass-rearing process, but to date, there has been no direct comparison of gel larval diet with traditional solid diets. In the present study, the performance of flies reared on gel larval diet was compared with the performance of flies reared on carrot and lucerne chaff diets. In addition, to investigate whether the performance of reared flies depends on ancestral diet as well as tested diet, we sourced eggs from a colony maintained on carrot diet and from a colony maintained on a lucerne chaff diet. Overall, the gel diet was as good or better than the solid diets in all quality control parameters, including, egg–larval duration, pupal number, pupal recovery, adult emergence, percentage of fliers, and rate of fliers. Of note, larvae developed faster and pupated more synchronously on the gel diet than on either of the solid diets. At the loading densities used, gel and carrot diets produced less waste than lucerne chaff diet. Gel diets offer a rearing solution for Queensland fruit fly that eliminates biological bulking agents and yields faster and more synchronous larval development without compromising productivity or quality.
Life after public employment retrenchment: evidence from Italian municipalities
Authors: Auricchio Marta , Ciani Emanuele , Dalmazzo Alberto , de Blasio Guido 
Published: May 2019

AbstractWe investigate the interaction between public and private employment at the local level. In contrast to previous literature, which has mainly examined public sector expansions, we provide evidence about the impact of downsizing. Using data from Italian municipalities, the IV strategy we adopt here exploits the fact that the contraction in public employment observed between the last two Censuses (2001–2011) was strongly influenced by the decision made by central government, with little reference to local economic conditions. Our results suggest that exogenous reductions in public employment stimulate the growth of private jobs, mostly in tradables. The change in local prices, especially for housing services, represents a relevant channel for the interplay between the tradable and non-tradable sectors.
Contemporary Associations of Exclusive Cigarette, Cigar, Pipe, and Smokeless Tobacco Use With Overall and Cause-Specific Mortality in the United States
Authors: Inoue-Choi Maki , Shiels Meredith S , McNeel Timothy S , Graubard Barry I , Hatsukami Dorothy , Freedman Neal D 
Published: May 2019

Abstract

Background
A growing proportion of tobacco users in the United States use non-cigarette products including cigars, pipes, and smokeless tobacco. Studies examining the disease and mortality risks of these products are urgently needed.

Methods
We harmonized tobacco use data from 165 335 adults in the 1991, 1992, 1998, 2000, 2005, and 2010 National Health Interview Surveys. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall and cause-specific mortality occurring through December 31, 2015, were estimated by exclusive use of cigarettes, cigars, pipes, or smokeless tobacco using Cox proportional hazards regression with age as the underlying time metric and never tobacco users as the referent group.

Results
Current use of cigarettes (HR = 2.23, 95% CI = 2.13 to 2.33) and smokeless tobacco (HR = 1.36, 95% CI = 1.17 to 1.59) were each associated with overall mortality. Relative to never tobacco users, higher risks were observed both in daily (HR = 2.34, 95% CI = 2.24 to 2.44) and nondaily (HR = 1.69, 95% CI = 1.54 to 1.86) cigarette smokers, with associations also observed across major smoking-related causes of death. Daily use of smokeless tobacco was also associated with overall mortality (HR = 1.41, 95% CI = 1.20 to 1.66) as was daily use of cigars (HR = 1.52, 95% CI = 1.12 to 2.08). Current smokeless tobacco use was associated with a higher risk of mortality from heart disease and smoking-related cancer, with strong associations observed for cancers of the oral cavity and bladder.

Conclusions
Exclusive daily use of cigarettes, cigars, and smokeless tobacco was associated with higher mortality risk. Tobacco control efforts should include cigars and smokeless tobacco.
A Numeral Oddity
Authors: Gasparri Luca 
Published: May 2019

Abstract
Natural language appears to allow the ascription of properties of numeral symbols to the denotation of number referring phrases. The paper describes the phenomenon and presents two alternative explanations for why it obtains. One combining an intuitive semantics for number referring phrases and a predicate-shifting mechanism, the other assigning number referring phrases a structured denotation consisting of two parts: a mathematical object (the number) and a contextually determined numeral symbol. Some preliminary observations in favor of the second analysis are offered.
Analysis of Risk Factors for Posterior C1 Screw-Related Complication: A Retrospective Study of 358 Posterior C1 Screws
Authors: Yi Ho Jun , Hong Jae Taek , Lee Jong Beom , Park Jong-Hyeok , Lee Jung Jae , Kim Il Sup , Yang Seung Ho , Sung Jae Hoon 
Published: May 2019

Abstract

BACKGROUND
Although C1 screw fixation is becoming popular, only a few studies have discussed about the risk factors and the patterns of C1 screw complications.

OBJECTIVE
To investigate the incidence of C1 screw complications and analyze the risk factors of the C1 screw complications.

METHODS
A total of 358 C1 screws in 180 consecutive patients were analyzed for C1 screw complications. Screw malposition, occipital neuralgia, major complications, and total C1 screw complications were analyzed.

RESULTS
The distribution of C1 screw entry point is as follows: inferior lateral mass, 317 screws (88.5 %); posterior arch (PA), 38 screws (10.7 %); and superior lateral mass, 3 screws (0.8 %). We sacrificed the C2 root for 127 screws (35.5 %). C1 instrumentation induced 3.1 % screw malposition, 6.4 % occipital neuralgia, 0.6 % vascular injury, and 3.4 % major complications. In multivariate analysis, deformity (odds ratio [OR]: 2.10, P = .003), traumatic pathology (OR: 4.97, P = .001), and PA entry point (OR: 3.38, P = .001) are independent factors of C1 screw malposition. C2 root resection can decrease the incidence of C1 screw malposition (OR: 0.38, P = .012), but it is a risk factor of occipital neuralgia (OR: 2.62, P = .034). Advanced surgical experience (OR: 0.09, P = .020) correlated with less major complication.

CONCLUSION
The incidence of C1 screw complications might not be uncommon, and deformity or traumatic pathology and PA entry point could be the risk factors to total C1 screw complications. The PA screw induces more malposition, but less occipital neuralgia. C2 root resection can reduce screw malposition, but increases occipital neuralgia.
Collective Action and Governance Activism*
Authors: Doidge Craig , Dyck Alexander , Mahmudi Hamed , Virani Aazam 
Published: May 2019

AbstractWe examine how an investor collective action organization (ICAO) enhances activism by institutional investors. The ICAO initiated a new form of engagement—private meetings with independent directors to discuss governance proposals. Compared with a single investor acting alone, the ICAO has stronger incentives to engage in activism. Its dollar holdings and voting power are six times larger and predict direct access to the board and the firms it engages. Firms engaged by the ICAO are at least 58% more likely than non-engaged firms to adopt the ICAO’s governance proposals that include adoption of majority voting, say-on-pay, and specific compensation policies. Engaged firms also increase CEO incentive pay. An event study around the announcement of the ICAO’s formation shows a positive impact on value that increases in both dollar holdings and voting power. We conclude that institutional investors improve governance outcomes through collective action.
MONET: a toolbox integrating top-performing methods for network modularisation
Authors: Tomasoni Mattia , Gómez Sergio , Crawford Jake , Zhang Weijia , Choobdar Sarvenaz , Marbach Daniel , Bergmann Sven 
Published: May 2019

AbstractSummaryWe define a disease module as a partition of a molecular network whose components are jointly associated with one or several diseases or risk factors thereof. Identification of such modules, across different types of networks, has great potential for elucidating disease mechanisms and establishing new powerful bio-markers. To this end, we launched the “Disease Module Identification (DMI) DREAM Challenge”, a community effort to build and evaluate unsupervised molecular network modularisation algorithms (Choobdar et al., 2018). Here we present MONET, a toolbox providing easy and unified access to the three top methods from the DMI DREAM Challenge for the bioinformatics community.Availability and ImplementationMONET is a command line tool for Linux, based on Docker and Singularity containers; the core algorithms were written in R, Python, Ada and C++. It is freely available for download at https://github.com/BergmannLab/MONET.gitContactmattia.tomasoni@unil.ch (MT); sven.bergmann@unil.ch (SB)
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons
Authors: Lewis Emily M.A. , Meganathan Kesavan , Baldridge Dustin , Gontarz Paul , Zhang Bo , Bonni Azad , Constantino John N. , Kroll Kristen L. 
Published: May 2019

AbstractBackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts to model ASD in human cellular systems have principally involved rarede novomutations associated with ASD phenocopies. However, by definition, these models are not representative of polygenic liability, which accounts for the vast share of population-attributable risk.MethodsHere, we performed what is, to our knowledge, the first attempt to model multiplex autism using patient-derived induced pluripotent stem cells (iPSCs) in a family manifesting incremental degrees of phenotypic expression of inherited liability (absent, intermediate, severe). The family members share an inherited variant of unknown significance inGPD2, a gene that was previously associated with developmental disability but here is insufficient by itself to cause ASD. iPSCs from three first-degree relatives and an unrelated control were differentiated into both cortical excitatory (cExN) and cortical inhibitory (cIN) neurons, and cellular phenotyping and transcriptomic analysis were conducted.ResultscExN neurospheres from the two affected individuals were reduced in size, compared to those derived from unaffected related and unrelated individuals. This reduction was, at least in part, due to increased apoptosis of cells from affected individuals upon initiation of cExN neural induction. Likewise, cIN neural progenitor cells from affected individuals exhibited increased apoptosis, compared to both unaffected individuals. Transcriptomic analysis of both cExN and cIN neural progenitor cells revealed distinct molecular signatures associated with affectation, including misregulation of suites of genes associated with neural development, neuronal function, and behavior, as well as altered expression of ASD risk-associated genes.ConclusionsWe have provided evidence of morphological, physiological, and transcriptomic signatures of polygenic liability to ASD from an analysis of cellular models derived from a multiplex autism family. ASD is commonly inherited on the basis of additive genetic liability. Therefore, identifying convergent cellular and molecular phenotypes resulting from polygenic and monogenic susceptibility may provide a critical bridge for determining which of the disparate effects of rare highly deleterious mutations might also apply to common autistic syndromes.
Estimation of a Time-varying Apparent Infection Rate from Plant Disease Progress Curves: A Particle Filter Approach
Authors: dos S Alves Kaique , Moraes Willian B , da Silva Wellington B , Del Ponte Emerson M 
Published: May 2019

AbstractThe parameters of the simplest (two-parameter) epidemiological models that best fit plant disease progress curve (DPC) data are the surrogate for initial inoculum (y0) and the (constant) apparent infection rate (r), both being useful for understanding, predicting and comparing epidemics. The assumption thatris constant is not reasonable and fluctuations are expected due to systematic changes in factors affecting infection (e.g. weather favorability, host susceptibility, etc.), thus leading to a time-varyingr, orr(t). An arrangement of these models (e.g. logistic, monomolecular, etc.) can be used to obtainrbetween two time points, given the disease (y) data are available. We evaluated a data assimilation technique, Particle Filter (PF), as an alternative method for estimatingr(t). Synthetic DPC data for a hypothetical polycyclic epidemics were simulated using the logistic differential equation for scenarios that combined five patterns ofr(t) (constant, increasing, decreasing, random or sinusoidal); five increasing time assessment interval (Δt= 1, 3, 5, 7 or 9 time units - t.u.); and two levels of noise (α = 0.1 or 0.25) assigned toy(t). The analyses of 50 simulated 60-t.u. DPCs showed that the errors of PF-derivedwere lower (RMSE < 0.05) for Δt< 5 t.u. and least affected by the presence of noise in the measure compared with the logit-derivedr(t). The ability to more accurately estimater(t) using the novel method may be useful to increase knowledge of field epidemics and identify within-season drivers that may explainr(t) behaviour.
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation
Authors: Bhargava Pavan , Mische Leah , Smith Matthew D. , Harrington Emily , Fitzgerald Kathryn C , Martin Kyle , Kim Sol , Reyes Arthur Anthony , Gonzalez-Cardona Jaime , Volsko Christina , Singh Sonal , Varanasi Kesava , Sotirchos Elias S. , Nourbakhsh Bardia , Dutta Ranjan , Mowry Ellen M. , Waubant Emmanuelle , Calabresi Peter A. 
Published: May 2019

AbstractMultiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including the CNS and immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, we identified lower levels of circulating bile acid metabolites in multiple cohorts of adult and pediatric MS patients compared to controls. In white matter lesions from MS brain tissue, we noted the presence of bile acid receptors on immune and glial cells. To mechanistically examine the implications of lower levels of bile acids in MS, we studied the in vitro effects of an endogenous bile acid – tauroursodeoxycholic acid (TUDCA) on astrocyte and microglial polarization. TUDCA prevented neurotoxic (A1) polarization of astrocytes and pro-inflammatory polarization of microglia in a dose-dependent manner. TUDCA supplementation in experimental autoimmune encephalomyelitis reduced severity of disease, based on behavioral and pathological measures. We demonstrate that bile acid metabolism is altered in MS; bile acid supplementation prevents polarization of astrocytes and microglia to neurotoxic phenotypes and ameliorates neuropathology in an animal model of MS. These findings identify dysregulated bile acid metabolism as a potential therapeutic target in MS.
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
Authors: Zheng Jie , Haberland Valeriia , Baird Denis , Walker Venexia , Haycock Philip , Hurle Mark , Gutteridge Alex , Erola Pau , Liu Yi , Luo Shan , Robinson Jamie , Richardson Tom G. , Staley James R. , Elsworth Benjamin , Burgess Stephen , Sun Benjamin B. , Danesh John , Runz Heiko , Maranville Joseph C. , Martin Hannah M. , Yarmolinsky James , Laurin Charles , Holmes Michael V. , Liu Jimmy , Estrada Karol , Santos Rita , McCarthy Linda , Waterworth Dawn , Nelson Matthew R. , Hemani Gibran , Smith George Davey , Butterworth Adam S. , Scott Robert A. , Gaunt Tom R. 
Published: May 2019

AbstractThe human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 130 (31.5%) were not supported by results of colocalization analyses, suggesting that genetic confounding due to linkage disequilibrium (LD) is widespread in naive phenome-wide association studies of proteins. Combining MR and colocalization evidence in cis-only analyses, we identified 111 putatively causal effects between 65 proteins and 52 disease-related phenotypes (www.epigraphdb.org/pqtl/). Evaluation of data from historic drug development programmes showed that target-indication pairs with MR and colocalization support were more likely to be approved, evidencing the value of our approach in identifying and prioritising potential therapeutic targets.
Anterior corpus callosum modulates symmetric forelimb movements during spontaneous food handling behavior of rats
Authors: Igarashi Masakazu , Akamine Yumiko , Wickens Jeffery R 
Published: May 2019

AbstractBimanual motor actions, such as threading a needle, require coordination of the movements of each hand according to the state of the other hand. By connecting homologous cortical regions between the two cerebral hemispheres, the corpus callosum is thought to play a key role in such bimanual coordination. However, direct experimental evidence of the contribution of the corpus callosum to natural behaviors requiring bimanual coordination, such as feeding, is lacking. We investigated the hypothesis that the corpus callosum mediates bimanual movements during food-handling behavior. We first traced the forelimb-related components of the motor corpus callosum in Long-Evans rats, and found that the callosal fiber bundle from the forelimb motor areas passes through the anterior part of the corpus callosum. We then confirmed by electrophysiological recordings that blocking the axonal conduction of fibers in the anterior corpus callosum reduced neural transmission between cortical forelimb areas. The causal role of corpus callosum in bimanual coordination was then tested by analyzing forelimb kinematics during object manipulation, before and after blocking axonal conduction in the anterior corpus callosum. We found the frequency of occurrence of symmetric bimanual movements was reduced by inhibition of anterior corpus callosum. In contrast, asymmetric bimanual movement was increased. Our findings suggest that the anterior corpus callosum coordinates the direction of bimanual movement.
Does deliberation really need more effort than intuition? A test using event-related brain potential
Authors: Zeng Jianmin , Tang Dinglan , Yu Jia , Zhang Qinglin , Nusbaum Howard 
Published: May 2019

AbstractIntuition and deliberation are two strategies for problem-solving and decision-making. It is commonly believed that deliberation requires more effort than intuition. However, to date, neural evidence approving or disapproving this point is scarce. To explore this issue, we asked participants to play two well-matched games requiring either deliberation or intuition. Using event-related brain potential (ERP) technique, we found: (1) Deliberation elicited more deflective ERP than intuition during −1000 ~ −500 ms before the response, which is consistent with the common belief. (2) More importantly, intuition evoked more deflective ERP than deliberation during 550 ~ 650 ms after the onset of the stimulus, which suggests that intuition may need more effort than deliberation at early stage, contradicting the common belief.
A general spectral decomposition of causal influences applied to integrated information
Authors: Cohen Dror , Sasai Shuntaro , Tsuchiya Naotsugu , Oizumi Masafumi 
Published: May 2019

AbstractQuantifying causal influences between elements of a system remains a central topic in many fields of research. In neuroscience, causal influences among neurons, quantified as integrated information, have been suggested to play a critical role in supporting subjective conscious experience. Recent empirical work has shown that the spectral decomposition of causal influences can reveal frequency-specific influences that are not observed in the time-domain. To date however, a spectral decomposition of integrated information has not been put forward. In this paper, we propose a spectral decomposition of integrated information in linear autoregressive processes. Our proposal is based on a general and flexible framework for deriving the spectral decompositions of causal influences in autoregressive processes. We show that the framework can retrieve the spectral decompositions of other well-known measures such as Granger causality. In simulation, we demonstrate a complex interplay between the spectral decomposition of integrated information and other measures that is not observed in the time-domain. We propose that the spectral decomposition of integrated information will be particularly useful when the underlying frequency-specific causal influences are masked in the time-domain. The proposed method opens the door for empirically investigating the relevance of integrated information to subjective conscious experience in a frequency-specific manner.Author summaryUnderstanding how different parts of the brain influence each other is fundamental to neuroscience. Integrated information measures overall causal influences in the brain and has been theorized to directly relate to subjective consciousness experience. For example, integrated information is predicted to be high during wakefulness and low during sleep or general anesthesia. At the same time, neural activity is characterized by well-known spectral signatures. For example, there is a prominent increase in low frequency power of neural activity during sleep and general anesthesia. Taking account of the spectral characteristics of neural activity, it is important to separately quantify integrated information at each frequency. In this paper, we propose a method for decomposing integrated information in the frequency domain. The proposed framework is general and can be used to derive the spectral decomposition of other well-known measures such as Granger causality. The spectral decomposition of integrated information we propose will allow empirically investigating the relationship between neural spectral signatures, integrated information and subjective consciousness experience.