bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dialectical Relationship Between Burnout and Work Engagement: A Network Approach
Authors: Hafstad Marius D. , Ebrahimi Omid V. , Fostervold Knut Inge 
Published: December 2024

ABSTRACTBased on previous empirical evidence, scholars have argued for a dialectical relationship between burnout and work engagement. However, these conclusions largely rely on latent variable models, which have inherent limitations due to strong hierarchical assumptions about data. As a result, previous findings should be considered preliminary indications rather than conclusive evidence. In this study, we introduce network analysis to investigate the relationship between burnout and work engagement. We demonstrate its utility by comparing the fit indices of the network model and three factor models in a cross‐national sample with 2469 employees from Norway and 879 employees from the US and UK. Based on theory and fit indices, we conclude that the network model was preferred in both samples. Using this model, we uncovered positive relationships between two work engagement variables and the exhaustion component of burnout. Theoretically, this study broadens our understanding and show support for the dialectical relationship between burnout and work engagement. Furthermore, by introducing the network model to empirical research, we provide a novel approach that contribute to nuance and ideas for research on burnout and work engagement. Practically, our results offer insightful data on possible points for intervention between burnout and work engagement variables.
ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization
Authors: He Yu , Peng Ejun , Ba Xiaozhuo , Wu Jian , Deng Wen , Huang Qiu , Tong Yonghua , Shang Haojie , Zhong Zichen , Liu Xiao , Zhang Yanlong , Ye Tao , Yang Xiaoqi , Wang Kangyang , Xie Yabin , Jiang Kehua , Xia Ding , Chen Zhiqiang , Tang Kun 
Published: December 2024

AbstractEmerging studies have demonstrated that M1 macrophage polarization and oxidative stress play important roles in calcium oxalate (CaOx) induced kidney injury, which leads to increased crystals deposition. ROS scavenging nanozymes and kidney‐targeted nanoparticles for antioxidant drugs delivery have emerged as an arisen methodology for kidney injury therapy. However, cell membrane biomimetic‐modified nanozymes as anti‐inflammatory drug delivery systems for the treatment of kidney injury is rarely reported. Herein, the ROS responsive red blood cell‐membrane‐coated resatorvid‐loaded cerium oxide nanoparticles (RBCM@CeO2/TAK‐242) are constructed to suppress CaOx induced kidney injury and crystals deposition. In vitro, RBCM@CeO2/TAK‐242 shows effective internalization by renal tubular epithelial cells, along with demonstrated antioxidative, anti‐inflammatory, and macrophage reprogramming effects. Glyoxalate(Gly)‐induced renal CaOx crystals mouse model is established, RBCM@CeO2/TAK‐242 shows excellent injured kidney targeting and biosafety, and could effectively suppress CaOx induced kidney injury and crystals deposition. RBCM@CeO2/TAK‐242 has a dual protective effect by both inhibiting oxidative stress and modulating macrophage polarization in vivo. In addition, RNA seq analysis reveals that RBCM@CeO2/TAK‐242 protects against CaOx induced kidney injury via suppressing the TLR4/NF‐κB pathway. This study provides an innovative strategy for RBCM@CeO2/TAK‐242 as injured kidney targeting and dual protective effects for the treatment of CaOx induced kidney injury and crystals deposition.
Chloride Engineering for Boosting Perovskite Photovoltaics: Impact on Precursor Coordination, Crystallization, and Film Quality
Authors: Li Bo , Pu Wei , Zhang Meng , Liu Yang , Li Mengjie 
Published: December 2024

AbstractPerovskite solar cells (PSCs) have seen rapid advancements over the past decade, driven by their exceptional optoelectronic properties and high power conversion efficiencies. Cl‐based additives strategy has significantly contributed to these advancements by enhancing crystallinity, improving preferred orientation, and optimizing the surface morphology of perovskite films. This review provides a comprehensive summary of recent advancements and insights into the critical role of Cl‐based additives in perovskite photovoltaics, focusing on the mechanisms behind Cl incorporation and its effects on film and device performance. First, the impact of Cl on precursor solution coordination and colloidal characteristics is discussed. Then, how Cl‐based additives influence the phase transitions of perovskites, including methylammonium lead iodide (MAPbI3), formamidinium lead iodide (FAPbI3), and 2D perovskites is examined. Furthermore, the impact of Cl‐based interfacial treatments on perovskite film quality is explored. Based on these insights, the overall impact of Cl treatments is also reviewed on the properties of perovskite films. Finally, a brief overview of the remaining challenges and future perspectives are provided to guide ongoing research efforts toward optimizing Cl additive engineering for high‐performance PSCs.
Unveiling Covalent Triazine Frameworks for Lithium Metal Anodes: Recent Developments and Prospective Advances
Authors: Aslam Junaid , Waseem Muhammad Ahsan , Lu Xiao‐Meng , Wu Songling , Sun Weiwei , Wang Yong 
Published: December 2024

AbstractLithium metal batteries (LMBs) are distinguished by their elevated energy densities which represent themselves as the formidable contenders for the forthcoming generation of energy storage technologies. Nonetheless, their cycling efficiency is hindered owing to unregulated growth of lithium dendrites and unstable solid electrolyte interphase (SEI). This raises serious safety concerns while rendering LMBs unfeasible for real‐world implementation. Covalent Triazine Frameworks (CTFs) have emerged as a promising class of 2D nanomaterials due to their unique properties such as high surface area, chemical stability, tailorable properties, porosity and high N‐containing groups. These groups serve as an efficient acceptor for Li. Consequently, the problem of lithium dendrite formation is significantly reduced. This review offers an extensive examination of CTF based anode materials utilized to address the challenges associated with lithium dendrites in LMBs. It is outline future prospects and provide recommendations for the design and engineering of lithium metal anodes (LMAs) and architectures that can make LMBs viable for practical use. This review also highlights promising strategies for surmounting challenges to ensure the safety and efficiency of LMBs.
Regulating Mitochondrial Aging via Targeting the Gut‐Bone Axis in BMSCs With Oral Hydrogel Microspheres to Inhibit Bone Loss
Authors: Qu Xiao , xie Zhou , Zhang Jun , Huang Yanran , Zhao Runhan , Li Ningdao , Wang Juan , Chen Liang , Cui Wenguo , Luo Xiaoji 
Published: December 2024

AbstractThe gut‐bone axis is a promising target for osteoporosis treatment, yet existing delivery systems lack precise targeting. Herein, an oral hydrogel microsphere system (E7‐Lipo@Alg/Cs) is developed using gas microfluidic and ionic crosslinking technologies to deliver drugs to bone marrow mesenchymal stem cells (BMSCs) via the gut‐bone axis, regulating mitochondrial aging. A BMSC‐affine peptide is conjugated onto liposomes encapsulating Fisetin, followed by incorporation into alginate‐calcium hydrogel microspheres. Chitosan is electrostatically adsorbed onto the microsphere surface, creating a core‐shell structure that adheres to intestinal epithelial cells, withstands gastric acid, and facilitates targeted delivery to BMSCs through the intestinal‐bone axis. In vitro, the system effectively enhances mitochondrial function and reverses BMSC aging, while in vivo studies demonstrate prolonged drug activity, restored osteogenic differentiation, and bone regeneration. RNA‐seq indicates activation of the AMPK‐SIRT1 pathway, reversing mitochondrial aging in BMSCs and promoting aged bone tissue regeneration. This oral hydrogel microsphere system provides a targeted and efficient strategy for regulating mitochondrial function and preventing bone loss, offering significant clinical potential for osteoporosis treatment.
Visible light‐responsive azo‐based smart materials: Design, performance, and applications in energy storage
Authors: Lv Shurui , Zhang Yuang , Wang Wentao , Zhang Shufen , Tang Bingtao 
Published: December 2024

AbstractAzobenzene and its derivatives are the most extensively investigated and applied molecular photoswitches, which can undergo reversible transformation between trans and cis isomers upon irradiation with light at specific wavelengths. Through structural geometry transformation, the property alterations can be integrated into smart materials to meet diverse application requirements. Most azo‐based photoswitches require UV light for activation. However, complete activation within the visible or even near‐infrared light range could offer several benefits for photoswitch applications, including improved biocompatibility, better light penetration, and enhanced solar light utilization efficiency. This review presents an overview of the development of visible‐light responsive azo‐based materials, covering molecular design strategies and their applications in energy storage. Recent efforts aimed at enhancing the performance of azo‐based energy storage materials are highlighted. According to the different strategies for improving energy storage properties, these materials are categorized as those that directly increase isomerization energy and those that introduce phase transition energy. Furthermore, we discuss the challenges and opportunities in this field with a view to inspire further exploration.
Seismic Performance of Shaped Steel Reinforced High‐Strength Concrete Walls: Cyclic Loading Test and Analytical Modeling
Authors: Zhang Qiang , Ma Linyuan , Zhao Bin , Ding Kun , Ni Xiangyong 
Published: December 2024

ABSTRACTThe thickness of the bottom shear walls in tall and super‐tall structures is often designed too large to meet the limit requirements of axial compression ratios, which increases the weight and cost of the structure. To address this issue, high‐strength concrete (HSC) and shaped steel are combined to form composite shear wall members. This paper focuses on seismic performance and analytical hysteresis model of steel reinforced HSC shear walls (SRHCW) under high axial compressive load. Firstly, the reversed cyclic test was conducted to investigate the influence of concrete strength and the steel ratio on the seismic performance of SRHCWs by comparing the failure mechanism, hysteretic curves, stiffness degradation, ductility, energy dissipation, and steel bar strain variation of each specimen. Then, a hysteresis model for SRHCWs was established, and the model can be used for the nonlinear analysis and seismic performance evaluation of SRHCWs. Finally, the accuracy of the proposed hysteresis model was evaluated by the experimental data. The experimental results show that under high axial compression ratio, the interstory drift ratio capacity of SRHCWs can reach 3.03% showing excellent deformation performance. The wall specimens built with different strength concrete and shaped steel ratios exhibited similar strength, deformation, and initial stiffness, indicating that the steel ratio of the wall can be effectively reduced by upgrading the concrete strength of the wall specimens while ensuring its seismic performance. The analytical model can well predict the hysteresis force–deformation curves of SRHCWs under high axial load ratios.
Ampelopsis japonica enhances the effect of radiotherapy in non-small cell lung cancer
Authors: Liu Zhaohua , Cui Peixia , Wu Qian , Ji Xiao 
Published: December 2024

Abstract
Background
Radiotherapy is widely used in the clinical treatment of non-small cell lung cancer (NSCLC); however, its effectiveness often proves unsatisfactory. Ampelopsis japonica (AJ) is a traditional Chinese herb with anti-inflammatory and anticancer activities. However, whether AJ could enhance the effect of radiotherapy in NSCLC needs to be further explored.

Methods
In vivo, BALB/c nude mice were used for a xenograft tumor model to explore whether AJ could enhance the effect of radiation therapy (RT) in NSCLC. In vitro, human NSCLC cell lines HCC827 and H1299 were used to explore the effect of AJ on the cell proliferation and apoptosis of RT-treated NSCLC. Moreover, bioinformatic analysis was performed to analyze the signaling pathways regulated by AJ.

Results
Ampelopsis japonica enhanced the inhibitory effect of RT on NSCLC tumor growth in vivo. Simultaneously, AJ further enhanced the inhibitory effect of RT on NSCLC proliferation and the promoting effect of RT on NSCLC apoptosis. Bioinformatic analysis showed that AJ regulated the PI3K-Akt signaling pathway. We confirmed that AJ decreased the protein levels of the PI3K-Akt signaling pathway. Furthermore, the combination of AJ and RT suppressed activation of the PI3K-Akt signaling pathway.

Conclusion
Ampelopsis japonica augmented the inhibitory impact of RT on NSCLC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Todesursachenstatistik – wie Fehlinterpretationen von Mortalitätsdaten vermieden werden
Authors: Stolpe Susanne , Kowall Bernd 
Published: December 2024

Zusammenfassung
Nationale Mortalitätsregister sind eine wichtige Datenquelle für das Monitoring der Bevölkerungsgesundheit. Aus Analysen insbesondere der kardiovaskulären Mortalität und speziell der Mortalität an koronarer Herzkrankheit werden Rückschlüsse auf die Qualität der Gesundheitsversorgung und Prävention gezogen. Um krankheitsspezifische Mortalitätsunterschiede zwischen Ländern und Veränderungen über die Zeit interpretieren zu können, ist es jedoch notwendig, die Grundlagen der unikausalen Todesursachenstatistik und die damit verbundenen Einschränkungen bei vergleichenden Aussagen zu kennen.
Schlussfolgerungen aus krankheitsspezifischen Mortalitätsdaten können wegen der sehr subjektiven Auswahl von Erkrankungen, die nach einer Leichenschau im Totenschein erfasst werden, problematisch sein. Unkenntnis der Leichenschauenden darüber, welche verschiedenen „Rollen“ einzelne, zum Zeitpunkt des Todes bekannte Erkrankungen innerhalb der zum Tode führenden Kausalkette einnehmen, kann zu unzureichend ausgefüllten Totenscheinen als Datengrundlage der Mortalitätsstatistik führen. Vergleiche krankheitsspezifischer Mortalitätsraten werden so durch verschiedene Anteile nichtinformativer, u. a. auch unbekannter Todesursachen und landesspezifische Präferenzen bei der Eintragung von Erkrankungen im Totenschein erschwert – insbesondere bei Multimorbidität. Die Morbidität einer Bevölkerung wird daher durch Mortalitätsraten nur eingeschränkt widergespiegelt. Begriffliche Unklarheiten in Bezug auf die Konzepte Letalität und Mortalität bei der Beschreibung von Mortalitätsraten können ebenfalls zu fehlerhaften Schlussfolgerungen führen.
Schulungen des ärztlichen Personals zum Ausfüllen eines Totenscheins und die geplante elektronische Todesbescheinigung könnten die Datengrundlage verbessern. Unabhängig davon verbessert die Kenntnis möglicher Fallstricke bei der Nutzung von Mortalitätsdaten die Qualität der Gesundheitsberichterstattung.
3-D-Druck in der Chirurgie: Relevanz der Bewertung der Technologiereife in Forschungsstudien zum Bioprinting
Authors: Laubach Markus , Hartmann Hanna , Holzapfel Boris M. , Mayer-Wagner Susanne , Schenke-Layland Katja , Hutmacher Dietmar W. 
Published: December 2024

ZusammenfassungBiologische 3‑D-Druckverfahren (sog. Bioprinting) sind eine Erweiterung dessen, was in den American Society for Testing and Materials(ASTM)- und International Organization for Standardization(ISO)-Normen als additive Fertigung definiert ist, und basieren auf dem automatisierten Druck von lebenden Zellen und Biomaterialien. Forschende und Expertinnen und Experten im Bereich der Biomaterialwissenschaften, der Gewebezüchtung und regenerativen Medizin („tissue engineering and regenerative medicine“, TE&RM) verweisen stets auf das Potenzial biologischer 3‑D-Druckverfahren und in Fachartikeln wird regelmäßig dessen baldige klinische Anwendung angekündigt. Wir argumentieren in dieser Arbeit, dass diese Ankündigungen regelhaft verfrüht und kontraproduktiv sind, da sie sich stark auf den technologischen Fortschritt konzentrieren, jedoch in der Regel die kritischen Phasen ignorieren, die durchlaufen werden müssen, um erfolgreich die Translation einer Technologie auf den Gesundheitsmarkt zu erzielen. Die Technologiereifegradskala („technology readiness level“, TRL) ist ein potenziell nützliches Instrument zur Messung der relativen Reife einer Technologie in Bezug auf die Überwindung einer Reihe kritischer Meilensteine. Wir schlagen eine Adaptierung der TRL-Skala vor und nutzen diese, um den aktuellen Stand der Forschung zu biologischen 3‑D-Druckverfahren zu diskutieren. Abschließend geben wir konkrete Empfehlungen zur Optimierung zukünftiger Forschungsprojekte, um den Weg für klinische Anwendungen des biologischen 3‑D-Drucks zu ebnen und damit einen direkten positiven Einfluss auf die chirurgische Patientenversorgung zu erzielen.
On Building Fine-Grained One-Way Functions from Strong Average-Case Hardness
Authors: Brzuska Chris , Couteau Geoffroy 
Published: December 2024

Abstract
Constructing one-way functions from average-case hardness is a long-standing open problem. A positive result would exclude Pessiland (Impagliazzo ’95) and establish a highly desirable win–win situation: either (symmetric) cryptography exists unconditionally, or all

$$\textsf{NP} $$

NP

problems can be solved efficiently on the average. Motivated by the lack of progress on this seemingly very hard question, we initiate the investigation of weaker yet meaningful candidate win–win results of the following type: either there are fine-grained one-way functions (FGOWF), or non-trivial speedups can be obtained for all

$$\textsf{NP} $$

NP

problems on the average. FGOWFs only require a fixed polynomial gap (as opposed to superpolynomial) between the running time of the function and the running time of an inverter. We obtain three main results: Construction. We show that if there is an

$$\textsf{NP} $$

NP

language having a very strong form of average-case hardness, which we call block finding hardness, then FGOWF exist. We provide heuristic support for this very strong average-case hardness notion by showing that it holds for a random language. Then, we study whether weaker (and more natural) forms of average-case hardness could already suffice to obtain FGOWF and obtain two negative results: Separation I. We provide a strong oracle separation for the implication (

$$\exists $$

∃

exponentially average-case hard

$$\textsf{NP} $$

NP

language

$$\implies $$

⇒

$$\exists $$

∃

FGOWF). Separation II. We provide a second strong negative result for an even weaker candidate win–win result. Namely, we rule out a relativizing proof for the implication (

$$\exists $$

∃

exponentially average-case

$$\textsf{NP} $$

NP

hard language whose hardness amplifies optimally through parallel repetitions

$$\implies $$

⇒

$$\exists $$

∃

FGOWF). This separation forms the core technical contribution of our work.
Common Grounds Forum – junge Menschen bekommen eine Stimme in der Digitalpolitik
Authors: Arlinghaus Clarissa Sabrina , Damm Birte , Heuer Kathleen , Elbracht Sébastien , Förster Florens , Sabrautzky Lea , Scharsich Julia 
Published: December 2024

ZusammenfassungIm Oktober 2023 diskutierten 83 Teilnehmende im Alter von 16 bis 35 Jahren auf dem Common Grounds Forum (CGF) in Berlin digital-politische Ideen, die in die Bereiche „ökologische Nachhaltigkeit“, „soziale Nachhaltigkeit“ und „Bildung in der digitalen Welt“ unterteilt wurden. Gemeinsam wurden in allen drei Bereichen Positionen samt Forderungen erarbeitet, die von zehn gewählten Vertreter*innen auf dem Digital-Gipfel 2023 in Jena vertreten wurden. In diesem Beitrag wird das CGF vorgestellt. Dabei wird auf das Format, die Ziele, die Durchführung, die Themen und die Reaktionen eingegangen. Das CGF setzt als Vorbild in der Digitalpolitik einen wichtigen Impuls, junge Menschen in die Digitalpolitik mit einzubeziehen. Wir hoffen, dass das CGF zu weiteren Formaten anregt, in denen jungen Menschen eine Stimme in der Digitalpolitik gegeben wird. Ebenso wünschen wir uns, dass die CGF-Forderungen nicht nur unter jungen Menschen diskutiert werden, sondern auch in anderen Altersgruppen weitergetragen und weiterentwickelt werden.
Etiology and therapy of pharyngeal perforations
Authors: Magradze Givi , Knopf Andreas , Becker Christoph , Ketterer Manuel Christoph 
Published: December 2024

Abstract
Objective
The primary aim of this study is to evaluate the impact of diagnostic procedures and treatment interventions performed at our medical institution on the final outcomes and survival rates of patients with iatrogenic and traumatic pharyngeal perforation (PP).

Materials and methods
We reviewed the medical records of 36 patients with iatrogenic and trauma-induced PP who were treated at the Quaternary Medical Center of Otorhinolaryngology between 2010 and 2020. Comorbidities were classified according to the Age-adjusted Charlson Comorbidity Index (ACCI) scoring system, and postoperative complications were classified according to the Clavien and Dindo scoring system.

Results
Of the 36 patients, 15 (41.7%) were male and 21 (58.3%) were female. The median age was 73 years, and PP was typically diagnosed within one day. Notably, the perforation site was identified in the hypopharynx in 29 (80.5%) patients. The median ACCI score was 4, with the most frequent ACCI score observed being 5. During the treatment course, 17 patients (47.2%) experienced complications, with 9 of these patients experiencing grade IV complications according to the Clavien and Dindo classification.

Conclusion
Our study showed that patients with hypopharyngeal perforations have an almost 42-fold higher risk of mortality during hospitalization compared to those with epipharyngeal or oropharyngeal perforations, though results are limited by the small sample size and the variable dates. Additionally, neurosurgery of the cervical spine, transesophageal echocardiography, and diverticular surgery emerged as procedures carrying the highest risk for pharyngeal perforations. Within our patient cohort, 4 patients (11.11%, all female) died during the treatment course.