bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Treffer im Kopf“ – Stigma psychischer Erkrankungen als Einflussfaktor auf die Inanspruchnahme von Hilfsangeboten durch VeteranInnen der Bundeswehr
Authors: Schuy Katrin , Brants Loni M. , Dors Simone , Ströhle Andreas , Zimmermann Peter Lutz , Willmund Gerd Dieter , Rau Heinrich , Siegel Stefan 
Published: May 2018

Zusammenfassung
Theoretischer Hintergrund und Ziel der Studie Stigmatisierung psychischer Erkrankungen ist ein Faktor, der die Inanspruchnahme von Hilfe behindern kann. Für die hier untersuchte Gruppe der VeteranInnen der Bundeswehr gibt es zum gegenwärtigen Zeitpunkt keine Studienergebnisse bezüglich des Zusammenhangs zwischen Stigma und Inanspruchnahme gesundheitlicher Hilfe. Ziel dieser Studie ist es, einen Überblick über das Stigmaerleben in einer Stichprobe von VeteranInnen der Bundeswehr zu erhalten.
Methodik Es wurden 43 narrative Interviews mit VeteranInnen der Bundeswehr geführt. Die daraus gewonnenen Daten wurden in mehreren Codierungsschritten analysiert. Es wurde untersucht, ob das Stigmaerleben von VeteranInnen der Bundeswehr sich gut durch das theoretisch begründete Stigmamodell von Link und Phelan abbilden lässt. Erste Hypothesen zu Stigma und Inanspruchnahme von Hilfe in dieser Stichprobe wurden aus dem Datenmaterial entwickelt.
Ergebnisse Die Stigmamodell nach Link und Phelan bildet das Stigmaerleben in der untersuchten Stichprobe gut ab. Wahrgenommenes und internalisiertes Stigma, berufliche Benachteiligung und sozialer Ausschluss, aber auch befürchtetes Unverständnis für die militärische Vergangenheit auf dem zivilen Sektor wurden als stigmarelevante Hauptbarrieren bei der Inanspruchnahme von Hilfe berichtet.
Schlussfolgerungen Es wurden Empfehlungen für Interventionen zum besseren Umgang mit den bestehenden Stigmata gegeben.
Approach to Reconstruction of Cheek Defects
Authors: Başağaoğlu Berkay , Bhadkamkar Mohin , Hollier Pierce , Reece Edward 
Published: May 2018

AbstractThe cheek is the largest facial unit with a prominent position on the face. Trauma, burns, and the resection of skin cancers constitute common sources of injury, potentially resulting in defects that, through natural healing, produce noticeable scarring. Surgical repair focuses on the reformation of three-dimensional geometries, proper establishment of symmetry, and the minimization of color and texture discrepancies to the surrounding. Defects located in this region may extend to the orbital, nasal, or buccal units and cause unique structural and functional disturbances. Furthermore, without appropriate repair, full-thickness defects involving the buccal mucosa may result in oral dysfunction. In this article, the authors provide a framework to approach various cheek defects and provide a review of the host of ideologies and techniques.
Early Pulmonary Interstitial Emphysema in Preterm Neonates—Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins
Authors: Gronbach Judith , Ehrhardt Harald , Zimmer Klaus-Peter , Waitz Markus 
Published: May 2018

AbstractEarly pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during noninvasive respiratory support. We further review the current evidence from the literature, specifically addressing on possible preventive measures and the respiratory management options of this acute pulmonary disease in high-risk neonates.
C1C2 Distraction and Compression Technique for Craniovertebral Junction Anomalies with Basilar Invagination and Irreducible Atlantoaxial Dislocation
Authors: Yerramneni Vamsi , Kotha Vamshi , Reddy Ramanadha 
Published: May 2018

AbstractThe authors describe four cases of basilar invagination (BI) with irreducible atlantoaxial dislocation (AAD) by distraction and compression technique. The article describes the technique in detail and the principles of the reduction achieved in all the planes by C1C2 screw placement, the cage insertion in the C1C2 joint, and manipulation of the joint. They described in the literature well-discussed various modifications and their application for treatment of BI with irreducible AAD.
Lipomyelomeningocele—Controversies in Management
Authors: Singh Abhishek , Ghosh Samarendranath , Chaudhuri Anup , Sadique Shahid , Chaudhuri Subhamitra 
Published: May 2018

AbstractManagement of lipomyelomeningocele is one of the most discussed and controversial topics in recent years. Till date, there is no consensus on the most appropriate mode of management for lipomyelomeningocele, particularly in asymptomatic patients. This article tries to sort out controversies associated with lipomyelomeningocele based on various literatures and also takes into account patient profile of a developing country.
Social Media in Shoulder & Elbow Surgery: An Analysis of Twitter and Instagram
Authors: Ramkumar Prem , Navarro Sergio , Cornaghie Margaret , Haeberle Heather , Hameed Hafsah , Schickendantz Mark , Ricchetti Eric , Iannotti Joseph 
Published: May 2018

AbstractSocial media provide a unique method of analyzing outcomes and quality in medicine. The purpose of this observational study was to investigate the nature of social media content related to shoulder and elbow (S&E) surgery posted by patients, surgeons, and hospitals. A public search of Instagram for a two-year period yielded 1,177 patient-related posts. A categorical system assessed the perspective, timing, tone, and content of each post. Twitter accounts of 77 S&E specialists from the top five ranked U.S. News & World Report institutions were analyzed for activity and content. 5,246 Twitter and Instagram posts for the institutions were analyzed for frequency and content. Most patient-related posts were by patients (68%), postoperative (82%), positive (87%), and centered on return-to-play for Tommy John (34%), surgical site for shoulder arthroplasty (52%), and activities of daily living for rotator cuff repair (22%). 37% of surgeons had active accounts averaging 46 posts, 87% of which were practice advertisements. Hospitals averaged 273 posts over the 2-year period, focusing on education (38%) and community (18%). S&E patients share outcomes on social media in a positive tone with procedure-dependent emphases. Surgeons on social media use sites for practice augmentation. Hospitals often focused posts towards educating the community.
Selection and environmental adaptation along a path to speciation in the Tibetan frogNanorana parkeri
Authors: Wang Guo-Dong , Zhang Bao-Lin , Zhou Wei-Wei , Li Yong-Xin , Jin Jie-Qiong , Shao Yong , Yang He-chuan , Liu Yan-Hu , Yan Fang , Chen Hong-Man , Jin Li , Gao Feng , Zhang Yaoguang , Li Haipeng , Mao Bingyu , Murphy Robert W. , Wake David B. , Zhang Ya-Ping , Che Jing 
Published: May 2018

SignificanceCentral topics in evolutionary biology include uncovering the processes and genetic bases of speciation and documenting environmental adaptations and processes responsible for them. The challenging environment of the Qinghai-Tibetan Plateau (QTP) facilitates such investigations, and the Tibetan frog,Nanorana parkeri, offers a unique opportunity to investigate these processes. A cohort of whole-genome sequences of 63 individuals from across its entire range opens avenues for incorporating population genomics into studies of speciation. Natural selection plays an important role in maintaining and driving the continuing divergence and reproductive isolation of populations of the species. The QTP is a natural laboratory for studying how selection drives adaptation, how environments influence evolutionary history, and how these factors can interact to provide insight into speciation.
Estrogen receptor β controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage
Authors: D’Errico F. , Goverse G. , Dai Y. , Wu W. , Stakenborg M. , Labeeuw E. , De Simone V. , Verstockt B. , Gomez-Pinilla P. J. , Warner M. , Di Leo A. , Matteoli G. , Gustafsson J. A. 
Published: May 2018

Significance
The selective estrogen receptor β (ERβ) agonist, LY3201, acts on enteric neuronal stem/progenitor cells, enhancing their capacity to generate enteric glial cells and neurons in vitro. Using two murine models of enteric nervous system damage, we showed that in vivo an ERβ agonist elicited accelerated reconstitution of the enteric neuron pool in the myenteric plexus. Our study suggests that selective ERβ agonists might be useful to promote neurogenesis in the damaged enteric nervous system.
The rich, the poor, the obvious
Authors: Günther Christine 
Published: May 2018

Abstract
This paper deals with nominal constructions such as the rich, the poor, the impossible, i.e. noun phrases that have a more or less fixed form and meaning ([+human] or [+abstract]). The focus is on the question of headedness and internal structure – the paper presents new data and ideas against the view that the adjective undergoes a conversion/nominalisation process. Drawing on parallels with elliptical noun phrases, it is argued that the adjective in the noun phrases under consideration remains an adjective which modifies a silent noun. This receives further support from a contrastive perspective – a comparison with German demonstrates that restrictions on the form and function of the construction derive from the rather impoverished inflectional system in English, as argued by Olsen (1988). The analysis proposed here addresses hitherto unaccounted-for aspects such as the use of an overt head noun (lexical or one) and non-adjectival elements in prenominal position (quantifiers, determiners other than the definite article) in nounless noun phrases.
Variable article usage with institutional nouns
Authors: Hundt Marianne 
Published: May 2018

Abstract
In English, singular institutional nouns like church or hospital are variably used with or without a definite article following verb-preposition collocations like go to and be at. British English has been reported to prefer the bare NP use whereas American English allegedly tends towards the variant with the definite article. Corpus data from the British National Corpus and the Corpus of Contemporary American English are used to test this hypothesis. In addition to regional variation, language-internal factors (choice and form of head noun, modification, semantics of the construction, collocational effects) are investigated. A variable rule analysis shows that regional variation is, in fact, not the most important factor and that choice of head noun and modification play a more important part. The results confirm that grammar often has a strong lexical base. Theoretical background to the study is provided by construction grammar, on the one hand, and previous work on category gradience.
Significance of an Increase in Diastolic Blood Pressure During a Stress Test in Terms of Comorbidities and Long-Term Total and CV Mortality
Authors: Sydó Nóra , Sydó Tibor , Gonzalez Carta Karina A , Hussain Nasir , Merkely Béla , Murphy Joseph G , Squires Ray W , Lopez-Jimenez Francisco , Allison Thomas G 
Published: May 2018

Abstract

BACKGROUND
A decrease in diastolic blood pressure (DBP) with exercise is considered normal, but the significance of an increase in DBP has not been validated. Our aim was to determine the relationship of DBP increasing on a stress test regarding comorbidities and mortality.

METHODS
Our database was reviewed from 1993 to 2010 using the first stress test of a patient. Non-Minnesota residence, baseline cardiovascular (CV) disease, rest DBP &lt;60 or &gt;100 mm Hg, and age &lt;30 or ≥80 were exclusion criteria. DBP response was classified: normal if peak DBP–rest DBP &lt; 0, borderline 0–9, and abnormal ≥10 mm Hg. Mortality was determined from Mayo Clinic records and Minnesota Death Index. Logistic regression was used to determine the relationship of DBP response to the presence of comorbidities. Cox regression was used to determine total and CV mortality risk by DBP response. All analyses were adjusted for age, sex, and resting DBP.

RESULTS
Twenty thousand seven hundred sixty patients were included (51 ± 11 years, female n = 7,314). Rest/peak averaged DBP 82 ± 8/69 ± 15 mm Hg in normal vs. 79 ± 9/82 ± 9 mm Hg in borderline vs. 76 ± 9/92 ± 11 mm Hg in abnormal DBP response. There were 1,582 deaths (8%) with 557 (3%) CV deaths over 12 ± 5 years of follow-up. In patients with borderline and abnormal DBP response, odds ratios for obesity, hypertension, diabetes, and current smoking were significant, while hazard ratios for total and CV death were not significant compared with patients with normal DBP response.

CONCLUSIONS
DBP response to exercise is significantly associated with important comorbidities at the time of the stress test but does not add to the prognostic yield of stress test.
Evaluating the consistency of large-scale pharmacogenomic studies
Authors: Rahman Raziur , Dhruba Saugato Rahman , Matlock Kevin , De-Niz Carlos , Ghosh Souparno , Pal Ranadip 
Published: May 2018

AbstractRecent years have seen an increase in the availability of pharmacogenomic databases such as Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) that provide genomic and functional characterization information for multiple cell lines. Studies have alluded to the fact that specific characterizations may be inconsistent between different databases. Analysis of the potential discrepancies in the different databases is highly significant, as these sources are frequently used to analyze and validate methodologies for personalized cancer therapies. In this article, we review the recent developments in investigating the correspondence between different pharmacogenomics databases and discuss the potential factors that require attention when incorporating these sources in any modeling analysis. Furthermore, we explored the consistency among these databases using copulas that can capture nonlinear dependencies between two sets of data.
Single cell clustering based on cell-pair differentiability correlation and variance analysis
Authors: Jiang Hao , Sohn Lydia L , Huang Haiyan , Chen Luonan 
Published: May 2018

Abstract

Motivation
The rapid advancement of single cell technologies has shed new light on the complex mechanisms of cellular heterogeneity. Identification of intercellular transcriptomic heterogeneity is one of the most critical tasks in single-cell RNA-sequencing studies.

Results
We propose a new cell similarity measure based on cell-pair differentiability correlation, which is derived from gene differential pattern among all cell pairs. Through plugging into the framework of hierarchical clustering with this new measure, we further develop a variance analysis based clustering algorithm ‘Corr’ that can determine cluster number automatically and identify cell types accurately. The robustness and superiority of the proposed algorithm are compared with representative algorithms: shared nearest neighbor (SNN)-Cliq and several other state-of-the-art clustering methods, on many benchmark or real single cell RNA-sequencing datasets in terms of both internal criteria (clustering number and accuracy) and external criteria (purity, adjusted rand index, F1-measure). Moreover, differentiability vector with our new measure provides a new means in identifying potential biomarkers from cancer related single cell datasets even with strong noise. Prognosis analyses from independent datasets of cancers confirmed the effectiveness of our ‘Corr’ method.

Availability and implementation
The source code (Matlab) is available at http://sysbio.sibcb.ac.cn/cb/chenlab/soft/Corr--SourceCodes.zip

Supplementary information
Supplementary data are available at Bioinformatics online.
EBIC: an evolutionary-based parallel biclustering algorithm for pattern discovery
Authors: Orzechowski Patryk , Sipper Moshe , Huang Xiuzhen , Moore Jason H 
Published: May 2018

AbstractMotivationBiclustering algorithms are commonly used for gene expression data analysis. However, accurate identification of meaningful structures is very challenging and state-of-the-art methods are incapable of discovering with high accuracy different patterns of high biological relevance.ResultsIn this paper, a novel biclustering algorithm based on evolutionary computation, a sub-field of artificial intelligence, is introduced. The method called EBIC aims to detect order-preserving patterns in complex data. EBIC is capable of discovering multiple complex patterns with unprecedented accuracy in real gene expression datasets. It is also one of the very few biclustering methods designed for parallel environments with multiple graphics processing units. We demonstrate that EBIC greatly outperforms state-of-the-art biclustering methods, in terms of recovery and relevance, on both synthetic and genetic datasets. EBIC also yields results over 12 times faster than the most accurate reference algorithms.Availability and implementationEBIC source code is available on GitHub at https://github.com/EpistasisLab/ebic.Supplementary informationSupplementary data are available at Bioinformatics online.
Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults
Authors: Knight Jamie E , Bennett David A , Piccinin Andrea M 
Published: May 2018

Abstract

Objectives
To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.

Methods
Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.

Results
Individuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.

Discussion
BSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.
Laser Interstitial Thermal Therapy as a Primary Treatment for Deep Inaccessible Gliomas
Authors: Shah Ashish H , Burks Joshua D , Buttrick Simon S , Debs Luca , Ivan Michael E , Komotar Ricardo J 
Published: May 2018

Abstract

BACKGROUND
Treatment strategies for deep intracranial gliomas remain limited to stereotactic biopsy in many cases due to the morbidity of aggressive surgical resection. Since no cytoreductive therapy is offered, outcomes have been demonstrably poor compared to patients who are able to undergo primary surgical resection.

OBJECTIVE
To present our practice, in an effort to reduce morbidity and still offer cytoreductive treatment, of offering the possibility of laser interstitial thermal therapy (LITT) for the primary treatment of intracranial deep gliomas that would be otherwise unamenable for resection.

METHODS
From 2010 to 2017, 74 patients were identified from a single surgeon at a single tertiary care referral center who had been treated with LITT. We conducted an exploratory cohort study on patients (n = 6) who have undergone contemporaneous biopsy and laser ablation for the treatment of deep gliomas with a mean tumor volume of 10.9 cc (range 4.2-52 cc).

RESULTS
In our cohort, mean extent of ablation (EOA) was 98.5% on postoperative MRI; mean progression-free survival was 14.3 mo, and 5 patients (83%) remained alive at mean follow-up time of 19.7 mo without any complications. Additionally, there was a negative linear relationship between preoperative lesion size and EOA (P < .04) when analyzed with previously reported series.

CONCLUSION
Although our series is small, we suggest that LITT can be a safe alternative cytoreductive therapy for deep surgically inaccessible gliomas. Given the known benefit of near gross total resection for high-grade gliomas, we believe LITT may improve survival for these patients and complement adjuvant treatments if patients are appropriately selected.
Study Protocol for a Randomized Controlled Trial Evaluating the Efficacy of an Evidence-Based iPad-App for Cognitive Rehabilitation in Patients with Primary Brain Tumors
Authors: van der Linden Sophie Dorothee , Sitskoorn Margriet Maria , Rutten Geert-Jan Maria , Gehring Karin 
Published: May 2018

Abstract

BACKGROUND
Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.

OBJECTIVE
To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.

METHODS
Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation, compensation training, and retraining. Patients are advised to spend 3 h per week on the program for 10 wk. Immediately after completion of the program and a half-year thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.

EXPECTED OUTCOMES
We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.

DISCUSSION
The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.
In Situ Left Azygous Anterior Cerebral Artery to Right Pericallosal Artery Bypass for Treatment of a Giant Right A1/2 Aneurysm: 2-Dimensional Operative Video
Authors: Rajah Gary , Hoeprich Mark , Narayanan Sandra , Guthikonda Murali , Mittal Sandeep 
Published: May 2018

Abstract
Here we present a 46-yr-old man with recurrent syncopal episodes thought to be of cardiac origin. He was eventually found to harbor a giant, partially thrombosed, saccular aneurysm arising from the A1/A2 segment of the right anterior cerebral artery with foramen of Monro obstruction and a trapped left-sided ventricular system. An azygous left A2 artery segment supplied both callosomarginal arteries. We performed an in situ side-to-side anastomosis between the distal left azygous anterior cerebral artery and the right pericallosal artery, which was previously supplied by the right A1. The right A1 was clip ligated, and the aneurysm evacuated with an ultrasonic aspirator. Postoperatively, the patient did well with no recurrence of the aneurysm and resolution of his preoperative obstructive hydrocephalus. He continues to be independent >7 yr post surgery. His 6-mo follow-up angiogram revealed a patent bypass.