bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging the senses
Authors: Cerreta Suzanne , Trofimovich Pavel 
Published: May 2018

Abstract
This case study examined the benefits of a sensory-based approach for teaching second language pronunciation to actors, addressing the unique learning goal of nativelike speech for nonnative professional actors. Two French Canadian actors (Marianne and Sebastian) were followed over 10 weeks of pronunciation instruction based on Knight’s (2012) theatrical voice methods and Gibson’s (1969) principles of sensory learning. Audio samples from scripted performances before and after instruction were rated for global and linguistic measures by 10 linguistically trained listeners and for performance measures by 10 advanced acting students. Listener ratings showed a significant improvement in accentedness for Marianne and greater comprehensibility for both actors, while qualitative data revealed actors’ preferences for different types of instruction. Results suggest that sensory learning appears beneficial for some learners and that pronunciation instruction could be supplemented with sensory-based activities.
Variation in hesitation
Authors: Graham Lamar A. 
Published: May 2018

Abstract
This study explored the influence of social and syntactic-pragmatic factors on a speaker’s choice between hesitation markers
este and eh in oral discourse. Data collected from San Juan (PR), Mexico City, Montevideo,
and Medellín were analyzed as a large corpus and on an individual country basis. Este was found to be the most
prevalent hesitation marker overall and within three of the four countries studied. On an overall level, the factors of city,
education level, gender, and position of the marker within the turn were found to be statistically significant to hesitation
marker choice, while age was not. On a per-city basis, education was significant everywhere, age and gender were significant
everywhere except Medellín, and turn position was significant everywhere except San Juan. The lack of uniformity in the results
suggests that speakers’ choice between este and eh is affected differently by these factors in
each area.
Análisis cognitivo-discursivo y situacional de las formas de tratamiento en función de sujeto y de objeto en español
Authors: Serrano María José 
Published: May 2018

AbstractoLas formas de sujeto y de objeto de segunda persona singulartú/ustedyte/a ti; le, lo, la/a ustedson recursos que posee la lengua española para indexar a los participantes en las distintas situaciones discursivas. Pocos estudios han profundizado en los valores cognitivos que subyacen a esta elección y, de forma general, se prefiere seguir aludiendo al eje de solidaridad-poder para su explicación. Para ello se suele recurrir a un conjunto de factores meramente descriptivos (edad, distancia social, respeto, etc.). Este trabajo pretende contribuir al desarrollo del conocimiento de estos pronombres desde una perspectiva discursivo-cognitiva y situacional, que, además presenta como novedad la distinción entre las funciones de sujeto pronominal y objeto de persona. Para ello se realizará un análisis cognitivo-discursivo basado en la prominencia de los referentes de estas formas en distintos géneros y situaciones comunicativas y entre hablantes de distintas afiliaciones socioprofesionales. Se utilizarán textos delCorpus Conversacional del Español de Canarias(CCEC).
Green tea extracts reduce leukocyte cell–Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet
Authors: Onishi Shintaro , Kitazawa Hidefumi , Meguro Shinichi , Tokimitsu Ichiro 
Published: May 2018

ABSTRACT
Epidemiological studies suggest that green tea extracts (GTEs), including catechins such as epigallocatechin gallate and epicatechin gallate, have a beneficial effect on obesity, hyperglycemia, insulin resistance, endothelial dysfunction, and inflammation. Although several studies have shown that catechins directly modulate the cellular and molecular alterations in the liver tissue, the contributions of indirect mechanisms underlying these systemic effects of catechins remain unclear. In this study, we report that, in the C57BL/6J mouse liver, GTEs reduce high-fat diet-induced increases in the levels of hepatokines, liver-derived secretary proteins such as leukocyte cell-derived chemotaxin 2 and selenoprotein P production, which have been shown to induce systemic adverse effects, including several metabolic diseases. These findings suggest that the systemic effects of GTEs involve the regulation of hepatokine production as an indirect mechanism.
1399 H&E-stained sentinel lymph node sections of breast cancer patients: the CAMELYON dataset
Authors: Litjens Geert , Bandi Peter , Ehteshami Bejnordi Babak , Geessink Oscar , Balkenhol Maschenka , Bult Peter , Halilovic Altuna , Hermsen Meyke , van de Loo Rob , Vogels Rob , Manson Quirine F , Stathonikos Nikolas , Baidoshvili Alexi , van Diest Paul , Wauters Carla , van Dijk Marcory , van der Laak Jeroen 
Published: May 2018

Abstract

Background
The presence of lymph node metastases is one of the most important factors in breast cancer prognosis. The most common way to assess regional lymph node status is the sentinel lymph node procedure. The sentinel lymph node is the most likely lymph node to contain metastasized cancer cells and is excised, histopathologically processed, and examined by a pathologist. This tedious examination process is time-consuming and can lead to small metastases being missed. However, recent advances in whole-slide imaging and machine learning have opened an avenue for analysis of digitized lymph node sections with computer algorithms. For example, convolutional neural networks, a type of machine-learning algorithm, can be used to automatically detect cancer metastases in lymph nodes with high accuracy. To train machine-learning models, large, well-curated datasets are needed.

Results
We released a dataset of 1,399 annotated whole-slide images (WSIs) of lymph nodes, both with and without metastases, in 3 terabytes of data in the context of the CAMELYON16 and CAMELYON17 Grand Challenges. Slides were collected from five medical centers to cover a broad range of image appearance and staining variations. Each WSI has a slide-level label indicating whether it contains no metastases, macro-metastases, micro-metastases, or isolated tumor cells. Furthermore, for 209 WSIs, detailed hand-drawn contours for all metastases are provided. Last, open-source software tools to visualize and interact with the data have been made available.

Conclusions
A unique dataset of annotated, whole-slide digital histopathology images has been provided with high potential for re-use.
Motivational Theories of Agenda-Setting Effects: An Information Selection and Processing Model of Attribute Agenda-Setting
Authors: Camaj Lindita 
Published: May 2018

AbstractThis study explores how agenda-setting theory works in a fragmented media environment while examining psychological motivations that drive selective exposure and information processing in an electoral context. The data suggest that regardless of motivational goals, people with a moderate active need for orientation (NFO) spent more time engaged in cross-network exposure to news media than the other groups. However, driven by directional goals, they were more apt to engage in biased information processing that increased agenda-setting outcomes on candidate attributes. Overall, this study suggests that NFO predicts information-seeking behavior, while motivated reasoning explains how people processed information. Exposure to partisan news reporting on cable television exhibited the strongest agenda-setting associations on candidate attributes.
Parenting Attitudes and Public Support for Political Authoritarianism in Latin America
Authors: Azpuru Dinorah , Malone Mary Fran T 
Published: May 2018

AbstractDespite nearly three decades of democratic rule throughout the Latin American region, public support for authoritarian norms has persisted. These “pockets of authoritarianism” can bolster support for policies and practices that weaken democratic governance, such as allowing authorities to abuse power. We examine why some Latin Americans endorse nondemocratic governance options by testing the predictive power of a psychological measure of authoritarianism, operationalized as support for particular child-rearing practices. We find that this psychological variable explains support for several nondemocratic governance options in the region: presidential limits on the opposition, iron-fist policies, torture of suspected criminals, and a military coup. Authoritarian parenting attitudes are also correlated with perceptions that political minorities threaten the country and lower support for democracy.
Anti-leukemic effects of all-trans retinoic acid in combination with Daratumumab in acute myeloid leukemia
Authors: Buteyn Nathaniel J , Fatehchand Kavin , Santhanam Ramasamy , Fang Huiqing , Dettorre Gino M , Gautam Shalini , Harrington Bonnie K , Henderson Sally E , Merchand-Reyes Giovanna , Mo Xiaokui , Benson Don M , Carson William E , Vasu Sumithira , Byrd John C , Butchar Jonathan P , Tridandapani Susheela 
Published: May 2018

Abstract
Acute myeloid leukemia (AML) remains a significant health problem, with poor outcomes despite chemotherapy and bone marrow transplants. Although one form of AML, acute promyelocytic leukemia (APL), is successfully treated with all-trans retinoic acid (ATRA), this drug is seemingly ineffective against all other forms of AML. Here, we show that ATRA up-regulates CD38 expression on AML blasts to sufficient levels that promote antibody-mediated fratricide following the addition of anti-CD38 daratumumab (DARA). The combination of ATRA plus DARA induced Fc-dependent conjugate formation and cytotoxicity among AML blasts in vitro. Combination treatment also led to reduction in tumor volume and resulted in increased overall survival in murine engraftment models of AML. These results suggest that, although ATRA does not induce differentiation of non-APL, it may be effective as a therapy in conjunction with DARA.
How to Solve the Puzzle of Dion and Theon Without Losing Your Head
Authors: Carmichael Chad 
Published: May 2018

AbstractThe ancient puzzle of Dion and Theon has given rise to a surprising array of apparently implausible views. For example, in order to solve the puzzle, several philosophers have been led to deny the existence of their own feet, others have denied that objects can gain and lose parts, and large numbers of philosophers have embraced the thesis that distinct objects can occupy the same space, having all their material parts in common. In this paper, I argue for an alternative approach: I claim that human beings have ordinary parts—hands, heads, feet, and so on—but no extraordinary parts, such as ‘foot-complements’, the existence of which is essential to the puzzle. I rebut three objections to this approach: an objection that it is unacceptably metaphysically arbitrary, an objection that the view is incompatible with versions of the puzzle involving decapitation, and an objection concerning masses of matter. If we can believe that there are such things as hands and feet without involving ourselves in paradox, and without accepting large numbers of co-located material objects that share all their material parts, then that is what we should do. My view is the only known alternative which allows this.
Constraining the geometry of AGN outflows with reflection spectroscopy
Authors: Parker M L , Buisson D J K , Jiang(姜嘉陈) J , Gallo L C , Kara E , Matzeu G A , Walton D J 
Published: May 2018

ABSTRACT
We collate active galactic nuclei (AGN) with reported detections of both relativistic reflection and ultrafast outflows. By comparing the inclination of the inner disc from reflection with the line-of-sight velocity of the outflow, we show that it is possible to meaningfully constrain the geometry of the absorbing material. We find a clear relation between the velocity and inclination, and demonstrate that it can potentially be explained either by simple wind geometries or by absorption from the disc surface. Due to systematic errors and a shortage of high-quality simultaneous measurements our conclusions are tentative, but this study represents a proof-of-concept that has a great potential.
Indian Mental Healthcare Act, 2017: CBR Matrix for Inclusive Implementation
Authors: Sethi Deepa 
Published: May 2018

Abstract
India has witnessed a major shift from the predominant seclusion in the Indian Lunacy Act, 1912, when there was no effectiveness in the treatment provided, to the Mental Health Act, 1987, when the focus was on the treatment and care of mentally ill patients along with some efforts to de-stigmatize and ensure human rights, to the recent Mental Healthcare Act, 2017, which primarily focuses on the human rights of people with mental illness.
This article analyses the Indian Healthcare Act, 2017, which was passed on April 7, 2017. The IMHA 2017 is a welcome Act after its predecessor Mental Health Act, 1987; however, it is not the ultimate solution. This article analyses the IMHA 2017, highlights the impediments in its implementation and suggests a win–win model for its implementation. A tailored version of CBR matrix is proposed for the inclusive implementation of the IMHA, 2017.
Bazex syndrome in a patient with head and neck malignancy
Authors: Adelman Megan L. , Ho Quoc-Anh , Agrawal Amit 
Published: May 2018

ABSTRACT
Bazex syndrome (acrokeratosis paraneoplastica) is an uncommon dermatologic condition associated with an underlying malignancy, most commonly squamous cell carcinomas of the head and neck. This article describes Bazex syndrome in a 56-year-old woman who presented with bilateral cervical lymphadenopathy and a mass at the base of her tongue.
An Innovative Teaching Model Using Intraprofessional Simulations
Authors: Boothby Johanna , Gropelli Theresa , Succheralli Lauren 
Published: May 2018

Abstract
Nursing programs are challenged to develop innovative approaches for admitting more students while providing a quality education that prepares them for safe practice. A clinical teaching model using simulation was developed as an innovative way to improve intraprofessional collaboration among junior- and senior-level nursing students. Students enrolled in Adult Health, Critical Care, and Management clinical courses rotate into the simulation lab throughout the semester. These experiences, with modified standardized simulations and simulations developed by faculty, have assisted students with teamwork, effective communication skills, delegation, and prioritization of care.
Framing Medicine as a Moral Practice: An Introductory Medical School Course
Authors: Allos Ban Mishu , Yakes Elizabeth Ann , Fleming Amy , Cutrer William B. , Pilla Michael , Clair Walter , Fowler Michael , Miller Bonnie 
Published: May 2018

Problem
The transition into medical school represents a time of profound professional development for medical students. Many medical schools manage this transition with brief orientations followed by abrupt moves into the anatomy laboratory. Recognizing that early introduction of key humanistic concepts could have a lasting impact on students’ attitudes, faculty at the Vanderbilt University School of Medicine created the Foundations of the Profession (FoP) course to frame medicine as a moral practice.

Approach
The FoP course, offered annually since 2012, occurs during the first week of medical school. Using coronary artery disease with a chief complaint of angina as a core example, teams of students create variations of five hypothetical patients and walk them through potential care episodes. This allows students to compare the impact of many factors on a provider’s ability to uphold fundamental professional obligations. Students engage in readings, lectures, small-group discussions, clinic visits, and research on insurance plans. Faculty engage with students in small groups and establish a safe environment for discussion of challenging moral dilemmas.

Outcomes
From 2013 to 2016, 356 (97%) of the 368 first-year medical students who took the course submitted summative course evaluations. Of the respondents, 349 (98%) indicated they believed the course contributed to their professional development and supported their learning.

Next Steps
Future iterations of this course may include increased exposure to key educational faculty to solidify the formation of a moral scaffold on which to build subsequent knowledge.
Training Pediatricians to Address Health Disparities: An Innovative Residency Track Combining Global Health With Community Pediatrics and Advocacy
Authors: Pak-Gorstein Suzinne , Batra Maneesh , Johnston Brian , Grow H. Mollie , Grant Abigail , Shugerman Richard , Lago Sylvia , Stapleton F. Bruder , McPhillips Heather 
Published: May 2018

Problem
Pediatric residency programs have been tasked to train a workforce of pediatricians with skills in community pediatrics (CP) and advocacy, and knowledge of global child health priorities.

Approach
In 2009, the University of Washington (UW) Seattle Children’s Hospital pediatric residency program developed the Resident Education in Advocacy and Child Health (REACH) program, a combined pathway for global health (GH) and CP training. After participating in a combined curriculum, residents complete a community immersion either in Kisii, Kenya (GH) or rural Washington (CP). This approach provides an efficient use of faculty and administrative resources and delivers a sustainable and ethical strategy for inspiring pediatric residents to address child health problems at a systems level.

Outcomes
Between 2009 and 2013, the percentage of graduating residents from the UW pediatric residency program who rated GH training as “outstanding/excellent/good” increased from 58.4% to 100%, and the percentage rating community and population health training as “outstanding/excellent/good” increased from 56% to 88.8%. Annual applicant surveys in the period 2011–2014 revealed that the REACH program led a significant percentage of candidates to rank the UW pediatric residency more favorably because of its GH (37%–48%) and CP (55%–74%) training.

Next Steps
A mixed-methods assessment will evaluate the impact on resident confidence in core areas of community health and advocacy including collaborating with community groups, setting professional career goals, addressing underlying determinants of health during patient encounters, communicating in cross-cultural settings, and advocating for child health. A survey will assess outcomes on graduates’ careers.
Provider Perceptions of Bubble Continuous Positive Airway Pressure and Barriers to Implementation in a Level III Neonatal Unit in South India
Authors: Atreya Mihir R. , Lorenz John M. , Narendran Vivek 
Published: May 2018

Background:
Bubble continuous positive airway pressure (bCPAP) is a simple, safe, and cost-effective strategy to provide respiratory support to newborns with respiratory distress syndrome in resource-limited settings.

Purpose:
To understand whether implementation of bCPAP, relative to other modes of respiratory support in the care of newborns with respiratory distress syndrome, increases positive attitudes about its potential for consistent and widespread use among providers in neonatal intensive care units (NICUs) of lower middle-income countries.

Methods:
Semistructured qualitative interviews with 14 healthcare providers, including 5 neonatal nurses, 2 respiratory therapists, 5 postgraduate trainees in pediatrics, and 2 attending physicians, were conducted at a level III NICU in south India where bCPAP had been in consistent use for 6 years. Interviews were transcribed and then coded and categorized using NVivo 10 Software (QSR International, Victoria, Australia).

Findings:
Categories that emerged from our data include (1) perceived indications, (2) learning curve, (3) perceived costs, (4) perceived shortages, and (5) barriers to use. Providers believed that bCPAP was easy to learn and that it helped empower neonatal nurses in decision-making process. Participants provided a nuanced perspective of cost-benefit associated with bCPAP and that it helped make optimal use of limited resources. Participants identified several barriers to the implementation of bCPAP.

Implications for Practice:
Providers of a level III NICU in a lower- to middle-income country viewed the use of bCPAP favorably. Addressing context-specific barriers will be important for the successful widespread implementation of bCPAP.

Implications for Research:
Further research will need to focus on whether bCPAP can be safely implemented at level II NICUs.
Video Abstract Available at https://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx?videoId=30&autoPlay=true.
Telephone-Based Progressive Tinnitus Management for Persons With and Without Traumatic Brain Injury: A Randomized Controlled Trial
Authors: Henry James A. , Thielman Emily J. , Zaugg Tara L. , Kaelin Christine , McMillan Garnett P. , Schmidt Caroline J. , Myers Paula J. , Carlson Kathleen F. 
Published: May 2018

Objectives:
This randomized controlled trial evaluated the efficacy of delivering coping skills education from Progressive Tinnitus Management (PTM) by telephone (Tele-PTM). The trial followed a previous pilot study that showed positive results for Tele-PTM.

Design:
Participants included individuals with bothersome tinnitus (N = 205) located anywhere within the United States. A special emphasis was given to including individuals who had experienced one or more traumatic brain injuries (TBIs). Participants were randomized to either Tele-PTM intervention or 6-month wait-list control (WLC). The Tele-PTM intervention involved five telephone appointments—two led by an audiologist (teaching how to use therapeutic sound) and three by a psychologist (teaching coping skills derived from cognitive-behavioral therapy). It was hypothesized that Tele-PTM would be more effective than WLC in reducing functional effects of tinnitus as measured with the Tinnitus Functional Index. Additional outcome measures included the Self-Efficacy for Managing Reactions to Tinnitus questionnaire and the Hospital Anxiety and Depression Scale. The effect of Tele-PTM on outcomes was estimated using linear mixed models.

Results:
Overall results showed convincingly that the Tele-PTM group had significantly better outcomes than the WLC group. These results were consistent across all outcome measures, indicating not only a reduction of tinnitus functional distress but also increased self-efficacy. Improvements in measures of anxiety and depression were also observed. Tele-PTM participants in all TBI categories showed significant improvement.

Conclusions:
Results provide strong support for use of Tele-PTM methodology for persons with bothersome tinnitus, regardless of whether the person also has TBI symptoms. The effect size for Tele-PTM was high for the primary outcome measure, the Tinnitus Functional Index, and all other outcome measures showed significant improvement. Combined with our previous pilot study, the Tele-PTM method is validated for potential nationwide provision of tinnitus services.