bluuebunny/crossref_metadata_2025_split huggingface dataset:
Institutional drivers for corporate philanthropic activities in China: Mediating roles of top management participation
Authors: Ouyang Zhe , Cheng Peng , Liu Yang , Yang Ruiju 
Published: July 2019

AbstractOn the basis of institutional theory and upper echelon perspective, this study develops and tests an integrative model that links institutional pressures to corporate philanthropy through the top management. Specifically, the mediating influences of top management participation and the moderating roles of resource availability and regulatory control in these relationships are investigated. Results of a survey of 207 Chinese firms suggest that coercive, mimetic, and normative pressures are significantly related to top management participation. Top management participation has a significant mediating effect on the relationship among coercive, normative, and corporate philanthropic activities. Furthermore, results indicate that resource availability positively moderates the relationships between institutional pressures and corporate philanthropic activities, whereas regulatory control negatively moderates these relationships. The theoretical and managerial implications of this study are discussed.
Efficient Electrocatalytic CO2Reduction Driven by Ionic Liquid Buffer‐Like Solutions
Authors: Gonçalves Wellington D. G. , Zanatta Marcileia , Simon Nathalia M. , Rutzen Luciane M. , Walsh Darren A. , Dupont Jairton 
Published: July 2019

AbstractElectrocatalysis of CO2reduction in aqueous electrolytes containing the ionic liquid (IL) 1‐n‐butyl‐2,3‐dimethylimidazolium acetate ([BMMIm][OAc]) and DMSO proceeded at low overpotentials (−0.9 V vs. Ag/AgCl) at commercially‐available Au electrodes, with high selectivity for CO production (58 % faradaic efficiency at −1.6 V vs. Ag/AgCl). 0.43 mol CO2per mol IL could be absorbed into the electrolyte at atmospheric pressure, forming bicarbonate and providing a constant supply of dissolved CO2to the surface of the electrode. Electrocatalysis of CO2reduction in the electrolyte was facilitated by stabilization of CO2radical anions by the imidazolium cations of the IL and buffer‐like effects with bicarbonate.
Superior Selectivity and Tolerance towards Metal‐Ion Impurities of a Fe/N/C Catalyst for CO2 Reduction
Authors: Yang Hui‐Juan , Zhang Xue , Hong Yu‐Hao , Sari Hirbod Maleki Kheimeh , Zhou Zhi‐You , Sun Shi‐Gang , Li Xi‐Fei 
Published: July 2019

AbstractThe electrochemical CO2 reduction reaction (CO2RR) in aqueous solution inevitably competes with the hydrogen evolution reaction (HER), which results in a difficult separation of the complex products. In this study, a Fe/N/C catalyst derived from Fe(SCN)3 (labelled SMFeSCN) revealed a high CO Faradaic efficiency (FE) of 99 % at a moderate overpotential of 0.44 V. CO2RR and HER competed with each other for active sites on Fe/N/C. The high FE for CO production originated from the high content of micropores on the catalyst, which could suppress the side reactions by increasing CO2 uptake. More importantly, excellent tolerance towards metal‐ion impurities was demonstrated in Fe/N/C, which was primarily owing to the high specific surface area with scattered active sites. Thus, the Fe/N/C catalyst showed good activity for CO2RR without influencing the electrolyte purity, thus raising the possibility of its practical application.
Holey Assembly of Two‐Dimensional Iron‐Doped Nickel‐Cobalt Layered Double Hydroxide Nanosheets for Energy Conversion Application
Authors: Septiani Ni Luh Wulan , Kaneti Yusuf Valentino , Guo Yanna , Yuliarto Brian , Jiang Xuchuan , Ide Yusuke , Nugraha Nugraha , Dipojono Hermawan Kresno , Yu Aibing , Sugahara Yoshiyuki , Golberg Dmitri , Yamauchi Yusuke 
Published: July 2019

AbstractLayered double hydroxides (LDHs) containing first‐row transition metals such as Fe, Co, and Ni have attracted significant interest for electrocatalysis owing to their abundance and excellent performance for the oxygen evolution reaction (OER) in alkaline media. Herein, the assembly of holey iron‐doped nickel‐cobalt layered double hydroxide (NiCo‐LDH) nanosheets (‘holey nanosheets’) is demonstrated by employing uniform Ni–Co glycerate spheres as self‐templates. Iron doping was found to increase the rate of hydrolysis of Ni–Co glycerate spheres and induce the formation of a holey interconnected sheet‐like structure with small pores (1–10 nm) and a high specific surface area (279 m2 g−1). The optimum Fe‐doped NiCo‐LDH OER catalyst showed a low overpotential of 285 mV at a current density of 10 mA cm−2 and a low Tafel slope of 62 mV dec−1. The enhanced OER activity was attributed to (i) the high specific surface area of the holey nanosheets, which increases the number of active sites, and (ii) the improved kinetics and enhanced ion transport arising from the iron doping and synergistic effects.
Retinal microvascular dysfunction in patients with coronary artery disease with and without heart failure: a continuum?
Authors: Barthelmes Jens , Nägele Matthias P. , Cantatore Silviya , Novruzov Etibar , Ludovici Valeria , von Eckardstein Arnold , Frank Michelle , Ruschitzka Frank , Sudano Isabella , Flammer Andreas J. 
Published: July 2019

AbstractAimsDynamic retinal vessel analysis is a novel, non‐invasive method to assess microvascular function. The primary aim of this study was to investigate whether retinal microcirculation is impaired in patients with stable coronary artery disease (CAD) compared to patients with heart failure due to CAD (ischaemic heart failure, IHF).Methods and resultsA total of 150 adults were enrolled to prospectively assess micro‐ and macrovasculature. The pre‐defined primary outcome was flicker‐induced arterial dilatation (FIDa) in patients with CAD [n = 40; median age 63 years, interquartile range (IQR) 53–70] and IHF (n = 40; median age 63 years, IQR 59–71) compared to healthy controls (HC, n = 70; median age 57 years, IQR 41–69). Secondary outcomes included arterial stiffness, flow‐mediated dilatation, biomarkers, and ergospirometry parameters. Patients with CAD demonstrated impairment in FIDa that was even more pronounced in patients with IHF (CAD: 1.93 ± 0.28% vs. IHF: 0.41 ± 0.28%, P < 0.001; FIDa in HC: 3.69 ± 0.21%, both P < 0.001) adjusting for age, sex, concomitant medication, and co‐morbidities. While pulse wave velocity was increased and flow‐mediated dilatation reduced in CAD and IHF patients (both P < 0.001 compared to HC), neither differed between CAD and IHF patients. N‐terminal pro‐B‐type natriuretic peptide (r = −0.49, P < 0.001,) and high‐sensitivity troponin T (r = −0.28, P = 0.003) correlated with FIDa. Intriguingly, mean metabolic equivalents (5.3 ± 2.3 kcal/kg/h, n = 39) showed a positive correlation with FIDa (r = 0.58, P < 0.001).ConclusionThis study demonstrates a decline of retinal arterial function in CAD patients that is significantly more pronounced in the presence of reduced left ventricular ejection fraction, suggesting a continuum of microvascular damage.
Reasons for longer LOS at the emergency departments: Practical, patient‐centred, medical, or cultural?
Authors: Khorram‐Manesh Amir , Wennman Ingela , Andersson Björn , Dahlén Holmqvist Lina , Carlson Tobias , Carlström Eric 
Published: July 2019

SummaryEmergency department (ED) overcrowding is caused by external and/or internal factors. One critical internal factor, leading to longer length of stay (LOS) at ED (eg, frequent ED users), is the physician's uncertainty in management of patients with unclear diagnosis and or complex medical history. The aim of this study was to identify whether the causes of physicians' uncertainty was practical, patient‐centred, medical, or cultural.Using earlier published dimensions of uncertainty, 18 physicians were asked to reply to a template by choosing a relevant dimension that causes a delay in assessment of a known complex patient. This stage was completed by interviews through which participants had an opportunity to express their concerns and critical thoughts, if any. The data obtained from the template were collected and analysed. The interviews were recorded and transcribed verbatim. The results of the template indicated medical dimension as the main factor in delayed assessment of a complex patient. However, this finding was challenged by the results of the interviews, which indicated higher impact of personal/routines/cultural dimension (eg, being afraid of criticism, reprimand, and gossip or feelings of guilt).Although medical, patient‐centred, and practical issues are important causes of longer LOS at ED, physicians' working and professional environment may have a higher impact than previously perceived. The uncertainty caused by interpersonal, organisational, and cultural issues within a clinic/hospital seems to influence the physician's ability to make decisions and thus a patient's medical outcome.
Case of atypical femoral fractures that mimicked the typical imaging findings of prostate cancer‐induced bone metastasis
Authors: Nezu Kunihisa , Endo Yuji , Katayama Hiromichi , Nozawa Yoshihiro , Kyan Atsushi 
Published: July 2019

IntroductionAtypical femoral fractures are atraumatic or minimally traumatic fractures and rare side effects of bone resorption inhibitors. Bone resorption inhibitors are frequently used in the treatment of prostate cancer.Case presentationA 62‐year‐old man complained of difficulty in walking and left lower limb pain. Androgen deprivation and denosumab therapy for prostate cancer‐induced bone metastasis was initiated 27 months ago. Even though the prostate‐specific antigen level did not increase, imaging studies indicated the possibility of bone metastasis. The patient underwent bone biopsy; however, no malignancy was detected. Afterward, he had a fall, causing a complete fracture in his left femur.ConclusionAtypical femoral fractures occasionally mimic typical imaging findings and outcomes of bone metastasis. This case is important for recognizing such cases.
Recent advances and prospects toward blue perovskite materials and light‐emitting diodes
Authors: Fang Tao , Zhang Fengjuan , Yuan Shichen , Zeng Haibo , Song Jizhong 
Published: July 2019

AbstractPerovskite based light‐emitting diodes (PeLEDs) have become a powerful candidate for next‐generation solid‐state lightings and high‐definition displays due to their high photoluminescence quantum yield (PLQY), tunable emission wavelength over the visible spectrum, and narrow emission linewidths. Over the past few years, the development of red‐ and green‐emissive PeLEDs has rapidly increased, and the corresponding external quantum efficiencies (EQE) have exceeded 20%. However, the research progress of blue‐emitting PeLEDs is limited by its poor material quality and inappropriate device structure. Currently, the maximum EQE of blue PeLED is only 6.2%, which is far from the industrialization requirements. In order to promote the development of blue PeLEDs, we summarize the recent research progress of blue perovskite materials and LEDs and discuss several fatal challenges, mainly embodied in low efficiency and poor stability. In order to overcome these challenges, detailed analysis and strategies are put forward in terms of the materials and devices. For the former, we summarize the feasible strategy for the preparation of efficient and stable blue‐emissive perovskites using component engineering. For the latter, we analyze the advantages and limitations of the different strategies for blue‐emissive perovskite in LEDs. At the end of the review, a comprehensive outlook is detailed, including future development directions and several technical problems to be solved. Thus, we aim to highlight the significance and promote the industrialization of PeLEDs.
Investigation of role of urea in morphologically controlled synthesis of calcium‐bismuth bimetallic nanoparticles from chicken egg shells and its catalytic and fuel additive applications
Authors: Khan Shanza Rauf , Jamil Saba , Zahid Muhammad , Shahid Muhammad 
Published: July 2019

AbstractA comparative study on the role of urea in controlling the morphology of calcium‐bismuth (Ca5Bi3) bimetallic nanoparticles is carried out. Calcium‐bismuth bimetallic nanoparticles are synthesized in the presence and absence of urea using the solvothermal method. The morphology of the synthesized products is analyzed by scanning electron microscopy. The composition of the product is analyzed by energy‐dispersive X‐ray spectroscopic and X‐ray diffraction (XRD) analyses. Reitveld refinements are performed on the XRD data, and lattice parameters are optimized. Reitveld‐refined parameters are used to construct the structural model of the calcium‐bismuth product. The formation mechanism of needle like particles from an orthorhombic unit cell is also proposed. The degradation of Congo red dye is catalyzed by synthesized Ca5Bi3 bimetallic nanoneedles in an aqueous medium. The effect of catalyst dose on the apparent rate constant (kapp) of degradation is studied and compared with literature. Ca5Bi3 bimetallic nanoneedles are also used as an additive in commercial diesel obtained from Pakistan State Oil, Limited. The effect of an additive dose on the calorific value of diesel is studied. How the Ca5Bi3 additive influenced other fuel quality parameters such as flash point, fire point, pour point, cloud point, kinematic viscosity, and specific gravity is also studied.
A time‐dependent density functional theory study on the excited state behavior of a novel T2(OH)B molecule
Authors: Jia Min , Song Xiaoyan , Yang Xiaohui , Yang Dapeng 
Published: July 2019

AbstractA novel pH‐sensitive fluorescent probe T2(OH)B was selected to theoretically investigate its excited state hydrogen bonding effects and excited state intramolecular proton transfer (ESIPT) process. First, it was verified that one intramolecular hydrogen bond is formed spontaneously in T2(OH)B itself. Given the geometrical changes, we further confirm that the hydrogen bond should be strengthened in the first excited state. When it comes to the photoexcitation process, we present the charge redistribution around hydrogen bonding moieties facilitate the ESIPT tendency. The increased electronic densities around acceptor promote the attraction of hydrogen protons. The potential energy barrier in the constructed potential energy curves reveals that the ESIPT process of the T2(OH)B system should be ultrafast. And comparing several nonpolar solvents, we deem solvent polarity plays little role in the ESIPT reaction. Furthermore, we also search the S1‐state transition state structure along with the ESIPT path, based on which we simulate the intrinsic reaction coordinate path. We not only confirm the ESIPT mechanism presented in this work but also clarify the ultrafast excited state process and explain previous experiment. We sincerely hope that our theoretical work could guide novel applications based on the T2(OH)B system in future.
Immunoregulatory role of melatonin in cancer
Authors: Moradkhani Fatemeh , Moloudizargari Milad , Fallah Marjan , Asghari Narjes , Heidari Khoei Heidar , Asghari Mohammad Hossein 
Published: July 2019

AbstractMelatonin is a ubiquitous indole amine that plays a fundamental role in the regulation of the biological rhythm. Disrupted circadian rhythm alters the expression of clock genes and deregulates oncogenes, which finally promote tumor development and progression. An evidence supporting this notion is the higher risk of developing malignancies among night shift workers. Circadian secretion of the pineal hormone also synchronizes the immune system via a reciprocal association that exists between the immune system and melatonin. Immune cells are capable of melatonin biosynthesis in addition to the expression of its receptors. Melatonin induces big changes in different immune cell proportions, enhances their viability and improves immune cell metabolism in the tumor microenvironment. These effects might be directly mediated by melatonin receptors or indirectly through alterations in hormonal and cytokine release. Moreover, melatonin induces apoptosis in tumor cells via the intrinsic and extrinsic pathways of apoptosis, while it protectsthe immune cells. In general, melatonin has a profound impact on immune cell trafficking, cytokine production and apoptosis induction in malignant cells. On such a basis, using melatonin and resynchronization of sleep cycle may have potential implications in immune function enhancement against malignancies, which will be the focus of the present paper.
Soluble guanylate cyclase isoenzymes: The expression of α1, α2, β1, and β2 subunits in the benign and malignant breast tumors
Authors: Mohammadoo‐Khorasani Milad , Karami Tehrani Fatemeh , Atri Morteza 
Published: July 2019

AbstractSoluble guanylate cyclase (sGC) encompasses α and β subunits. This study examined the expression of α1, α2, β1, and β2 subunits in the malignant and benign breast tumors using the Western blot  analysis. Both benign and malignant tumors showed a significantly higher expression of the α1 subunit in comparison with normal tissues (p < 0.0001). In contrast, the expression of α2 and β2 sGC were significantly lower in these tumors than normal tissues (p < .0015 and p < .001, p < .007 and p < .0001, respectively). The expression level of α1 sGC was significantly correlated with ER + PR+ (p < .0001). A significant correlation was also detected for sGC‐α1 and ‐α2 expression with c‐erbB2‐negative status (p < .01). However, the expression level of sGC was not associated with tumor stage, tumor grade, or other clinicopathological features. In conclusion, as the expression of α1 sGC is upregulated and α2 and β2 sGC are downregulated in malignant breast tumors. Variations in the expression of sGC isoenzymes may be suggested as an indicator to confirm the enzyme antitumor activity.
Transient severe conduction disturbances associated with ankylosing spondylitis
Authors: Ikeoka Kuniyasu , Nishikawa Nagahiro , Sakakibara Masayuki , Kawamoto Keisuke , Hoshida Shiro 
Published: July 2019

AbstractA 46‐year‐old man presented with advanced and complete atrioventricular block. He was diagnosed with human leukocyte antigen‐B27‐positive ankylosing spondylitis (AS) and treated with nonsteroidal anti‐inflammatory drugs for AS. The severe atrioventricular block spontaneously improved and resolved after 3 months of therapy. Sequential cardiac magnetic resonance imaging demonstrated transient myocardial high‐intensity signals in the basal septum close to the membranous portion of the septum. A pacemaker was not needed because of the reversible atrioventricular block.
Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells
Authors: Shen Er‐Dong , Zeng Qiang 
Published: July 2019

AbstractRadiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells. NPC tissues and normal nasopharyngeal tissues were collected. To evaluate the regulatory effects of the Numb/Notch signaling pathway, NPC cells were subjected to radiotherapy and various doses of the Numb/Notch signaling pathway inhibitor gamma secretase inhibitor (GSI). Next, the expression of Notch and Numb proteins was determined in NPC tissues and normal nasopharyngeal tissues, and the correlation of Notch and Numb protein expression with the clinicopathological features of NPC tissues was analyzed. Then, the effect of radiotherapy on NPC cell survival rate, survival fraction, apoptosis rate, proliferation, migration, and invasion as well as Numb/Notch signaling pathway‐related molecules was detected. The results demonstrated that the Numb/Notch signaling pathway was activated in NPC tissues. Following treatment with radiotherapy and GSI, the Numb/Notch signaling pathway was inhibited. In addition, the NPC cell survival rate, survival fraction, cell proliferation, migration, and invasion were decreased, whereas the colony number and apoptosis rate were increased. Following radiotherapy and GSI treatment, Numb expression was increased, whereas Notch1, Hes1, Jagged1, and c‐Myc expression was decreased. However, the greatest difference was noted upon treatment with radiotherapy +15 μM GSI. The results reported in this study suggest that a high dose of the inhibitor of the Numb/Notch signaling pathway GSI increased the radiation sensitivity in human NPC cells.
miR‐522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B
Authors: Zhang Hong‐Chang , Han Yan‐Yan , Zhang Xin‐Min , Xiao Nan , Jiang Tao , Zhu Shuang , Wang En‐Peng , Chen Chang‐Bao 
Published: July 2019

AbstractIt is well known that microRNAs (miRNAs) are crucial regulatory factors in tumorigenesis, as tumor suppressors or cancer‐promoting factors. However, the study of endometrial carcinoma relevance in miR‐522 is rare, indicating an undefined molecular mechanism for its role. Therefore, we performed this study to examine the role of miR‐522 on the biological behaviors of endometrial carcinoma. In this work, we found that miR‐522 was highly expressed in endometrial carcinoma and negatively regulated monoamine oxidase B (MAOB) expression. They also have the opposite effect on prognosis of endometrial carcinoma patients. More importantly, miR‐522 could decreased MAOB expression by binding to MAOB with a putative site, thereby promoting cell proliferation, migration, and invasion through in vitro functional analyses, including MTT assay, wound‐healing and transwell invasion experiments. Upregulation of MAOB rescued the impacts of miR‐522 mimic on cell behaviors. In conclusion, our observations demonstrated that miR‐522 accelerated the progression of endometrial carcinoma by inhibiting MAOB, which might lead to a novel therapeutic therapy for endometrial carcinoma.
Outcomes of head and neck surgery in patients with a history of solid organ transplantation
Authors: Al‐Qurayshi Zaid , Walsh Jarrett , Owen Scott , Randolph Gregory , Kandil Emad 
Published: July 2019

Objectives/HypothesisExamine the prevalence and outcomes of head and neck surgeries in patients with a history of organ transplantation.Study DesignA retrospective cross‐sectional analysis utilizing the Nationwide Readmissions Database, 2010 to 2014.MethodsThe study population included adults patients who underwent head and neck surgeries. Patients with a reported history of solid organ transplantation were compared to patients with no such history.ResultsThe study population included 322 transplant patients (76.4% kidney, 8.7% liver, 8.4% heart, 3.0% kidney/pancreas, 2.3% lung, 0.9% kidney/liver, 0.4% pancreas) and 120,401 controls who underwent comparable procedures. Main surgeries that were performed in cases included 37.8% parathyroid, 17.7% thyroid, 11.2% major salivary gland, 10.6% major mouth/tonsil, and 9.6% major nose/paranasal sinuses. Encountering transplant patients in otolaryngology practice has been increasing annually by three patients for every 10,000 procedures performed in the United States. There was no difference in the overall postoperative complications risk (12.5% vs. 10.1%, P = .26); however, cases had a higher risk of acute renal failure (5.4% vs. 1.1%, P < .001) and shock state (0.3% vs. 0.02%, P < .001). Readmission risk was higher for cases (6.8% vs. 3.4%, P = .003). There was no reported in‐hospital mortality among cases.ConclusionsTransplant patients are increasingly encountered in otolaryngology practices. The most common transplanted organ is kidney, and the most commonly performed procedure is parathyroidectomy.Level of EvidenceNALaryngoscope, 130:E89–E97, 2020