bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Genome-Wide Association Study of Sprint Performance in Elite Youth Football Players
Authors: Pickering Craig , Suraci Bruce , Semenova Ekaterina A. , Boulygina Eugenia A. , Kostryukova Elena S. , Kulemin Nickolay A. , Borisov Oleg V. , Khabibova Sofya A. , Larin Andrey K. , Pavlenko Alexander V. , Lyubaeva Ekaterina V. , Popov Daniil V. , Lysenko Evgeny A. , Vepkhvadze Tatiana F. , Lednev Egor M. , Leońska-Duniec Agata , Pająk Beata , Chycki Jakub , Moska Waldemar , Lulińska-Kuklik Ewelina , Dornowski Marcin , Maszczyk Adam , Bradley Ben , Kana-ah Adam , Cięszczyk Pawel , Generozov Edward V. , Ahmetov Ildus I. 
Published: July 2019

Abstract
Pickering, C, Suraci, B, Semenova, EA, Boulygina, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Leońska-Duniec, A, Pająk, B, Chycki, J, Moska, W, Lulińska-Kuklik, E, Dornowski, M, Maszczyk, A, Bradley, B, Kana-ah, A, Cięszczyk, P, Generozov, EV, and Ahmetov, II. A genome-wide association study of sprint performance in elite youth football players. J Strength Cond Res 33(9): 2344–2351, 2019—Sprint speed is an important component of football performance, with teams often placing a high value on sprint and acceleration ability. The aim of this study was to undertake the first genome-wide association study to identify genetic variants associated with sprint test performance in elite youth football players and to further validate the obtained results in additional studies. Using micro-array data (600 K–1.14 M single nucleotide polymorphisms [SNPs]) of 1,206 subjects, we identified 12 SNPs with suggestive significance after passing replication criteria. The polymorphism rs55743914 located in the PTPRK gene was found as the most significant for 5-m sprint test (p = 7.7 × 10−7). Seven of the discovered SNPs were also associated with sprint test performance in a cohort of 126 Polish women, and 4 were associated with power athlete status in a cohort of 399 elite Russian athletes. Six SNPs were associated with muscle fiber type in a cohort of 96 Russian subjects. We also examined genotype distributions and possible associations for 16 SNPs previously linked with sprint performance. Four SNPs (AGT rs699, HSD17B14 rs7247312, IGF2 rs680, and IL6 rs1800795) were associated with sprint test performance in this cohort. In addition, the G alleles of 2 SNPs in ADRB2 (rs1042713 & rs1042714) were significantly over-represented in these players compared with British and European controls. These results suggest that there is a genetic influence on sprint test performance in footballers, and identifies some of the genetic variants that help explain this influence.
Physiological Responses During Female Judo Combats: Impact of Combat Area Size and Effort to Pause Ratio Variations
Authors: Ouergui Ibrahim , Kamzi Sana , Houcine Nizar , Abedelmalek Salma , Bouassida Anissa , Bouhlel Ezdine , Franchini Emerson 
Published: July 2019

Abstract
Ouergui, I, Kamzi, S, Houcine, N, Abedelmalek, S, Bouassida, A, Bouhlel, E, and Franchini, E. Physiological responses during female judo combats: impact of combat area size and effort to pause ratio variations. J Strength Cond Res 35(7): 1987–1991, 2021—This study investigated the effect of area size (4 × 4, 6 × 6, and 8 × 8 m) and effort-pause ratio (free combat, 2:1 and 3:1) on the physiological and perceptive responses during female judo combats. Twelve female judo athletes (mean ± SD: age: 17.1 ± 0.4 years; height: 160 ± 7 cm; body mass: 59.8 ± 11.5 kg; body fat: 25.7 ± 5.5%; and judo experience: 8.4 ± 0.5 years) volunteered to perform nine 4-minute randoris randomly determined. Blood lactate [La] before and after combats, heart rate before combat (HRpre), mean HR (HRmean), peak HR (HRpeak), and rating of perceived exertion (RPE) immediately after the combats were assessed for each condition. Results showed that [La] pre and HR values did not differ according to time structure and area sizes (p > 0.05). However, [La] post was higher on free randori compared with 3:1 ratio (p = 0.006) and in the 4 × 4-m area compared with 6 × 6-m (p < 0.001) and 8 × 8-m (p = 0.036) areas. Moreover, RPE was higher in the 4 × 4 m compared with 8 × 8 m (p = 0.038). In conclusion, combining time structure and area sizes may alter physiological and perceptual responses during female judo randori. Moreover, combat-based exercises may be effective in preparing athletes to cope with physiological and technical demands of the combat by stressing properly the energy systems solicited during official competitions.
Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays
Authors: Kremling Karl A G , Diepenbrock Christine H , Gore Michael A , Buckler Edward S , Bandillo Nonoy B 
Published: July 2019

Abstract
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers. The recent advent of new technologies allows assaying and quantifying biological intermediates (hereafter endophenotypes) which are now readily measurable at a large scale across diverse individuals. The usefulness of endophenotypes for delineating the regulatory landscape of the genome and genetic dissection of complex trait variation remains underexplored in plants. The work presented here illustrated the utility of a large-scale (299-genotype and seven-tissue) gene expression resource to dissect traits across multiple levels of biological organization. Using single-tissue- and multi-tissue-based transcriptome-wide association studies (TWAS), we revealed that about half of the functional variation acts through altered transcript abundance for maize kernel traits, including 30 grain carotenoid abundance traits, 20 grain tocochromanol abundance traits, and 22 field-measured agronomic traits. Comparing the efficacy of TWAS with genome-wide association studies (GWAS) and an ensemble approach that combines both GWAS and TWAS, we demonstrated that results of TWAS in combination with GWAS increase the power to detect known genes and aid in prioritizing likely causal genes. Using a variance partitioning approach in the largely independent maize Nested Association Mapping (NAM) population, we also showed that the most strongly associated genes identified by combining GWAS and TWAS explain more heritable variance for a majority of traits than the heritability captured by the random genes and the genes identified by GWAS or TWAS alone. This not only improves the ability to link genes to phenotypes, but also highlights the phenotypic consequences of regulatory variation in plants.
Asociación entre embarazo adolescente e hiperbilirrubinemia y bajo peso al nacer: cohorte retrospectiva en un hospital en Perú, 2015-2016
Authors: Hernández Maldonado Cindy , Rosales Rimache Jaime 
Published: July 2019

Introducción. El embarazo adolescente en Perú es un problema de salud pública que presenta alta prevalencia en regiones como Ica, y se considera como una causa de ciertos desenlaces adversos a la salud del recién nacido como bajo peso e hiperbilirrubinemia. Métodos. Se diseñó una cohorte retrospectiva constituida por gestantes adolescentes entre 13 y 19 años, las cuales fueron divididas en dos grupos: grupo 1 (<18 años de edad) y grupo 2 (≥18 años de edad). Resultados. Se evaluaron 481 gestantes adolescentes, de las cuales el grupo 1 representó el 65,3%. Se encontró recién nacidos con bajo peso e hiperbilirrubinemia en el 3,3% y 18.9%, respectivamente. El análisis bivariado evidenció diferencias significativas (p<0,001) entre la mediana de edad gestacional entre madres con recién nacidos con peso normal y bajo peso, así como en relación al tipo de parto (cesárea y normal). En cuanto a la hiperbilirrubinemia, tanto el análisis bivariado como el multivariado no evidenciaron diferencias significativas. La regresión de Cox permitió evidenciar que las gestantes adolescentes del grupo 1 tuvieron casi 8 veces más riesgo (HR: 7,95, p<0,05) de tener un recién nacido con bajo peso en comparación a las gestantes del grupo 2. Conclusión. El embarazo adolescente está asociado al bajo peso al nacer, más no a la hiperbilirrubinemia neonatal.
Prácticas maternas de alimentación en niños de 6 a 24 meses atendidos en establecimientos de salud de Lima e Iquitos
Authors: Rojas-Guerrero Nady , Spinoza-Bernardo Sissy 
Published: July 2019

Introducción. Las prácticas de alimentación complementaria deficientes tienen un efecto negativo sobre el crecimiento y desarrollo de niños en la infancia. El Perú tiene una amplia diversidad cultural y variada idiosincrasia acerca de la alimentación y nutrición de los niños; sin embargo, existen escasas publicaciones sobre las prácticas de alimentación complementaria según región de residencia. Objetivo. Determinar las prácticas maternas de alimentación de niños de 6 a 24 meses atendidos en establecimientos de salud de Lima e Iquitos. Métodos. La unidad de análisis fue la madre de niño de 6 a 24 meses de edad. Se consideró un total de 151 madres en Lima y 168 en Iquitos. Para establecer la relación entre las prácticas de alimentación complementaria y la residencia, se utilizó la prueba Chi cuadrado con un nivel de significancia de 0,05. Resultados. 174 (54,55%) fueron mujeres, 191(59,87%) de los niños tenían entre 12 y 24 meses. Las madres tuvieron una edad mediana de 25 años. Hubo diferencia significativa en el cumplimiento de prácticas de alimentación complementaria entre los niños de ambas comunidades en: lactancia materna exclusiva antes de los 6 meses (p=0,007), dieta mínima aceptable (p=0,000) y en el consumo de multimicronutrientes (p=0,000). Conclusiones. Las diferencias entre las prácticas maternas de alimentación complementaria se evidencian en el incumplimiento de lactancia materna exclusiva y el consumo de multimicronutrientes para niños de Lima, y una mayor frecuencia de incumplimiento de una dieta mínima aceptable para niños de Iquitos.
Percepción del envejecimiento exitoso en docentes de una facultad de medicina
Authors: Martina Martha , Amemiya Isabel , Piscoya Julia , Pereyra Héctor , Moreno Zoila 
Published: July 2019

Introducción. En las últimas décadas, en nuestro país se están produciendo cambios en la estructura poblacional por edad, uno de los más importantes es el incremento de la población adulta mayor. Objetivos. Determinar la percepción de vivir un envejecimiento exitoso e identificar algunas variables asociadas con dicha percepción en los docentes adultos mayores de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Métodos. Estudio transversal y correlacional. Muestra de 106 docentes adultos mayores seleccionados por conveniencia, entre septiembre a noviembre 2017. Se utilizó el Inventario de Envejecimiento Exitoso de Meredith Troutman proporcionada por la propia autora. Resultados. La edad media fue de 67,38 ± 5,77 con un rango de 60 a 87 años. El 67% estaban casados; 47,7% vivía con su pareja y familiares, sólo cuatro docentes (3,8%) vivían solos sin ningún apoyo. El 70,1%(74) labora en la universidad 26 o más años; el 46,7%(50) son asociados; el 64,2%(68) es a tiempo parcial; el 46,7%(49) tiene maestría y el 26,4%(28) pertenecen a la ONP Ley 20530. El 76,3% de los docentes adultos mayores declararon que perciben un envejecimiento exitoso. Las dimensiones que más aportan al envejecimiento exitoso fueron mecanismos funcionales de rendimiento (88,7%) seguido de satisfacción con la vida (71,7%) y de los factores intrapsíquicos (69,5%). Conclusiones. El envejecimiento exitoso es mayoritario en los docentes adultos mayores de la facultad de medicina probablemente como consecuencia de un proceso de adaptación a los cambios propios del envejecimiento y a una intensa actividad intelectual previa a esta etapa.
Tumores del estroma gastrointestinal
Authors: Soriano-Lorenzo Jorge , Lima-Pérez Mayte , Soriano-García Jorge , Zaldívar-Blanco Karla , Fleites-Calvo Vilma 
Published: July 2019

Los tumores del estroma gastrointestinal (GIST) son neoplasias mesenquimales originadas en el tracto gastrointestinal. Su localización más frecuente es en estómago e intestino delgado. Pueden originarse a cualquier edad, pero más del 80% de los casos son mayores de 50 años sin predilección de sexo, aunque puede observarse en pacientes más jóvenes asociados a síndromes que predisponen el desarrollo de estos tumores. Presentan sintomatología inespecífica. La tomografía axial computarizada está recomendada para realizar el estudio de extensión y seguimiento de estos pacientes. Los marcadores inmunohistoquímicos más sensibles y específicos son el KIT y DOG1. El tratamiento en caso de lesiones primarias localizadas es la resección quirúrgica, con o sin terapia adyuvante con imatinib durante 3 años en dependencia del riesgo de recidiva. En los casos avanzados o metastásicos se recomienda terapia neoadyuvante con imatinib por tiempo indefinido; el tratamiento en casos de progresión o intolerancia a imatinib es el sunitinib.
50° Aniversario del fallecimiento del Prof. Dr. Hugo Pesce Pescetto (1969-2019)
Authors: Burstein Alva Zuño 
Published: July 2019

El 26 de julio del presente año 2019, se cumplirán 50 años de la lamentable desaparición fisica, a los 69 años de vida, de uno de los más destacados médicos del Perú, salubrista, leprólogo, intelectual vanguardista y humanista, el Prof. Dr. Hugo Pesce Pescetto (1900-1969). En el presente artículo se presenta una nota recordatoria sobre su destacada trayectoria y los homenajes póstumos que recibió.
Predictive Validity of the CRAFFT for Substance Use Disorder
Authors: Shenoi Rohit P. , Linakis James G. , Bromberg Julie R. , Casper T. Charles , Richards Rachel , Mello Michael J. , Chun Thomas H. , Spirito Anthony ,   PEDIATRIC EMERGENCY CARE APPLIED RESEARCH NETWORK
Published: July 2019

BACKGROUND
The utility of CRAFFT (Car, Relax, Alone, Forget, Friends, Trouble) in identifying current and future problematic substance use and substance use disorders (SUDs) in pediatric emergency department (PED) patients is unknown. We conducted a secondary analysis of a study in 16 PEDs to determine the concurrent and predictive validity of CRAFFT with respect to SUD.

METHODS:
At baseline, 4753 participants aged 12 to 17 years completed an assessment battery (CRAFFT and other measures of alcohol, drug use, and risk behaviors). A subsample was readministered the battery at 1-, 2-, and 3-year follow-up to investigate future SUDs.

RESULTS:
Of 2175 participants assigned to follow-up, 1493 (68.6%) completed 1-year, 1451 (66.7%) completed 2-year, and 1265 (58.1%) completed the 3-year follow-up. A baseline CRAFFT value of ≥2 was significantly associated with problematic substance use or mild or moderate to severe SUD diagnosis on the Diagnostic Interview Schedule for Children at baseline (P &lt; .001). The results persisted after 1, 2, and 3 years (P &lt; .001). The best combined sensitivity and specificity was achieved with a baseline CRAFFT value of ≥1 as a cutoff for predicting problematic substance use and a Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of mild SUD at 1, 2, and 3 years. The baseline CRAFFT score that best predicted a moderate to severe SUD at 1 year was ≥2; but at 2 and 3 years, the cutoff score was ≥1.

CONCLUSIONS:
CRAFFT has good concurrent validity for problematic substance use and SUD in PED patients and is useful in predicting SUDs at up to 3 years follow-up but with limited sensitivity.
Medan Makna Morfosemantik kata Auliya dalam Al-Qur’an: Kajian Semantik dengan Pendekatan Analisis Komponensial
Authors: Maksum Maksum , Tafiati Tafiati 
Published: July 2019

This research aims to observethe terrain of morpho-semantic meaning of the word auliya’ in the Qur'an; what words are included in the morpho-semantic field of the word auliya’, and how the features are useful. This study aims to gather words that are in the morpho-semantic field of the auliya’ word 'in the Qur'an, find their meaning features, common components of the meaning and components of differentiating meaning (diagnostic communication) so that the meaning can be obtained representative of the word auliya'. The study found 234 words incorporated into the auliya’ 'morpho-semantic field' in 69 forms, spread over 55 letters in 208 verses. All these words come from six basic forms which are classified into three classes of words. The analysis reveals root meanings (general meaning components), i.e., ASSEMBLING, REDUCING, GOVERNING (action), NEAR / NO DISTANCE, HELP, FULL OF LOVE, RESPONSIBLE, ALWAYS SUPERVISING (characters) and distinguishing components, consisting of the meaning of the basic form, namely, GOD, KING / AUTHORITY / MASTER, RELIGION, HERITAGE OF HERITAGE, CULTURE (perpetrator), TIME AND INSTITUTION (etc.) and grammatical meaning, namely, Al-Syakhsh (pronoun), Al-'Adad (numeral) , Al-Ta'yin (definite) and Al-Nau '(gender), besides the meaning of' ‘time'specifically for the class of verb.
A produção do Ensino Médio como um direito fundamental dos jovens brasileiros a partir das problematizações da juventude
Authors: Goulart Marcos Vinicius da Silva , Traversini Clarice Salete 
Published: July 2019

O texto objetiva analisar como as problematizações da juventude constituíram o Ensino Médio como direito fundamental dos jovens brasileiros desde o início da década de 2000. Utilizamos o conceito foucaultiano de problematização e optamos pela análise documental. O estudo permitiu referir que as problematizações desenvolveram: a) uma visão positiva dos jovens brasileiros; b) a institucionalização a nível governamental das discussões sobre juventude; c) a noção de que os jovens brasileiros são um grupo heterogêneo, que não pode ser enquadrado em um modelo único e ideal. Em síntese, os ditos sobre os jovens, além de instituir uma visão de juventude, também marcam uma disputa política em torno da melhor forma de educá-los.
Creating an Online Video Course for Computational Wave Propagation
Authors: Igel Heiner , Nies Maika , Joshi Rakshit , Perez Andrea , Vilacis Berta , Anger Sebastian , Igel Jonas K. H. , Keller Erik , Rubner Armin 
Published: July 2019

ABSTRACT
Teaching and training using online video material in science is on the rise. Science students entering universities today are of a “YouTube generation,” most likely already having a history of accessing educational videos for learning at school. Here, we report on our experiences with preparing a Massive Open Online Course (MOOC) for the COURSERA platform in the area of computational wave propagation. We describe the complexity of the process but also highlight the opportunities that this form of training offers on state‐of‐the‐art e‐learning platforms. It is foreseeable that in the future universities will promote combinations of direct and supervised online course learning, allowing for more flexibility and variability of training content. We propose that Earth‐Science‐specific databases with links to online courses should be developed, making such courses more accessible to the research community.
Pemanfaatan tanaman Tagetes erecta Linn. dalam kesehatan
Authors: Edy Hosea Jaya , Parwanto ML Edy 
Published: July 2019

Untuk mengembangkan obat baru, dewasa ini para peneliti berusaha untuk meneliti kandungan bahan alam, diantaranya kandungan zat dalam T. erecta Linn. Ekstrak etanol daun T.erecta Linn. diperoleh 17 senyawa dengan kandungan terbesar adalah senyawa neophytadiene diikuti 9,12,15-oktadecadienoic acid-methyl ester, hexadecanoic acid-methyl ester, palmitic acid, 9,12-oktadecadienoic acid, linolenic acid­-metil ester dan heptadecanoic acid. Tanaman T.erecta Linn. atau yang biasa dikenal dengan sebutan bunga tahi kotok memiliki kandungan kimia yang sangat bermanfaat untuk kesehatan. Bagian dari tanaman T.erecta Linn. yang telah diekstrak dengan berbagai macam pelarut juga telah terbukti memiliki sifat antioksidan, efek antibakteri dan mampu menyembuhkan luka. Ekstrak dari bagian tanaman T.erecta Linn. juga telah berhasil diformulasikan menjadi berbagai bentuk sedian farmasi seperti gel, krim, lotion antinyamuk dan juga pewarna rambut. Sedian farmasi dengan zat aktif ekstrak T.erecta Linn. tersebut terbukti memiliki efek yang baik dan tidak merugikan subyek uji.
An evaluation of the effectiveness of a community-based parenting empowerment program to improve nurturing care of young children in Kenya and Zambia
Authors: Wekulo Patricia K. , Murage Elizabeth K. , Donfouet Hermann P. , Onyango Silas O. , Okelo Kenneth O. , Wanjohi Milka N. , Murdock Dawn , Nyamor George , Munsongo Kelvin 
Published: July 2019

<p class="abstract"><strong>Background:</strong> Investing in parents and children during the critical period between birth and five years of a child’s life can have long-lasting benefits in the life of the child. Recently, the 2016 Lancet Series estimated that 250 million children aged less than five years in low- and middle-income countries (LMICs) are at risk of not reaching their developmental potential. Over 66 % of these, who live in sub-Saharan Africa and are at risk due to poor nutrition, exposure to poverty, high HIV prevalence as well as under stimulation in the home environment.</p><p class="abstract"><strong>Methods:</strong> The study will employ a cluster-randomized control trial design and will use a mixed-methods approach combining quantitative and qualitative methodologies <strong>(</strong>Concurrent Triangulation Design).<strong> </strong>This will be a two-arm study, where the first arm will participate in the parenting empowerment program implemented by the faith-based organizations, while the second (control) will not receive the parenting interventions. A total of 510 mother/primary caregiver-child dyads will be recruited into this study. We will estimate the causal effect of the intervention using mixed linear models and the Difference-in-Differences (DID) estimator.</p><p class="abstract"><strong>Conclusions: </strong> This implementation research will provide greater scientific rigor and a deeper process and outcome evaluation including measurement of child development outcomes. The findings will be useful for early childhood practitioners, multilateral stakeholders and funders as they provide information on the factors to consider in the implementation of high quality ECD interventions.</p><p class="abstract"><strong>Trial Registration: </strong>Ethical approval: ESRC P467/2018 and IRB No.00005948).</p>