bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syphilis Self-testing: A Nationwide Pragmatic Study Among Men Who Have Sex With Men in China
Authors: Wang Cheng , Cheng Weibin , Li Changchang , Tang Weiming , Ong Jason J , Smith M Kumi , Fu Hongyun , Marks Michael , Nie Juan , Zheng Heping , Tucker Joseph D , Yang Bin 
Published: June 2019

AbstractBackgroundSyphilis self-testing may help expand syphilis testing among men who have sex with men (MSM). China has rapidly scaled up human immunodeficiency virus (HIV) self-testing, creating an opportunity for integrated syphilis self-testing. However, there is a limited literature on implementing syphilis self-testing.MethodsA cross-sectional online survey was conducted among Chinese MSM in 2018. Participants completed a survey instrument including sociodemographic characteristics, sexual behaviors, syphilis self-testing, and HIV self-testing history. Multivariable logistic regression was conducted to identify correlates of syphilis self-testing. We also recorded potential harms associated with syphilis self-testing.ResultsSix hundred ninety-nine MSM from 89 cities in 21 provinces in China completed the study. A total of 361/699 (51.7%) men tested for syphilis, of whom 174/699 (24.9%) men used syphilis self-testing. Among 174 who had self-tested, 90 (51.7%) reported that the self-test was their first syphilis test and 161 (92.5%) reported that they undertook syphilis self-testing together with HIV self-testing. After adjusting for covariates, syphilis self-testing was correlated with disclosure of sexual orientation to family or friends (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.32–2.73), reporting 2–5 male sexual partners (aOR, 1.81; 95% CI, 1.04–3.16), HIV self-testing (aOR, 39.90; 95% CI, 17.00–93.61), and never tested for syphilis in the hospital (aOR, 2.96; 95% CI, 1.86–4.72). Self-reported harms associated with syphilis self-testing were minimal.ConclusionsScaling up syphilis self-testing could complement facility-based testing in China among MSM. Self-testing may increase first-time testing and has limited harms. Our findings suggest that syphilis self-testing could be integrated into HIV self-testing services.
Nuclear disarmament and the end of the chemical weapons ‘system of restraint’
Authors: Wirtz James J. 
Published: June 2019

Abstract
With the Cold War as a starting point, it was possible for decades to offer an optimistic assessment of a general trend towards disarmament when it came to describing the future of chemical and nuclear weapons. Recent developments, however, make it difficult to continue to advance this assessment. Equally disturbing is the fact that the greatest disarmament setbacks occurred in the realm of chemical weapons, the realm that enjoyed the greatest success. The article thus begins by making the case that developments in nuclear policies were actually on the side of the angels. Indeed, one could even have made the case that the international community was coming closer to treating nuclear weapons in the same manner as they treated chemical weapons, which had largely vanished from world politics by the turn of the century. The article then explores why the chemical weapons success story ended, and what its end might portend for the role of nuclear weapons in world politics.
Mortality from extrathymic malignancy after thymic tumour resections: incidences and risk factors
Authors: Hamaji Masatsugu , Sozu Takashi , Machida Ryunosuke , Watanabe Shun-Ichi , Yoshida Kazuo , Toyooka Shinichi , Tanahashi Masayuki , Kondo Kazuya , Horio Hirotoshi , Okumura Meinoshin , Date Hiroshi 
Published: June 2019

Abstract

OBJECTIVES
To identify risk factors associated with extrathymic malignancy-related mortality after thymic epithelial tumour resection.

METHODS
The Japanese Association for Research on the Thymus database registered the records of 2835 patients collected from 32 Japanese institutions from 1991 to 2010. The cumulative incidence function of death due to extrathymic malignancies or recurrence was calculated, with other causes of death as competing risks. Relevant risk factors associated with extrathymic malignancy-related deaths in patients with thymoma were evaluated using the Fine and Gray model.

RESULTS
In total, 2701 patients were eligible for the analysis (thymoma, 2374; thymic carcinoma, 273; thymic neuroendocrine tumour, 54). The median follow-up period was 4.6 years. The cumulative incidence function of death due to extrathymic malignancies at 10 years was 2.2% (3.2% due to recurrence) in patients with thymoma, 1.6% (38.6% due to recurrence) in patients with thymic carcinoma and 0% (36.6% due to recurrence) in patients with thymic neuroendocrine tumour. In the multivariable analysis, age (every 10 years) at thymectomy [hazard ratio (HR) 2.19, 95% confidence interval (CI) 1.53–3.14; P < 0.001], male gender (HR 2.62, 95% CI 1.19–5.77; P = 0.017) and previous malignancies (HR 3.09, 95% CI 1.18–8.11; P = 0.022) were significant factors for death due to extrathymic malignancies after thymectomy.

CONCLUSIONS
Continued management and early detection of extrathymic malignancies may improve survival of patients with thymoma who are male, of advanced age, or have previous malignancies. Prospective studies are required to further investigate the management of extrathymic malignancies.
Perverse Coherent Sheaves on Blow-ups at Codimension 2 Loci
Authors: Koseki Naoki 
Published: June 2019

Abstract
Let $f \colon X \to Y$ be the blow-up of a smooth projective variety $Y$ along its codimension two smooth closed subvariety. In this paper, we show that the moduli space of stable sheaves on $X$ and $Y$ are connected by a sequence of flip-like diagrams. The result is a higher dimensional generalization of the result of Nakajima and Yoshioka, which is the case of $\dim Y=2$. As an application of our general result, we study the birational geometry of the Hilbert scheme of two points.
3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress
Authors: Velez Daniel O , Ranamukhaarachchi Sural K , Kumar Aditya , Modi Rishi N , Lim Esther W , Engler Adam J , Metallo Christian M , Fraley Stephanie I 
Published: June 2019

AbstractThe collagen-rich tumor microenvironment plays a critical role in directing the migration behavior of cancer cells. 3D collagen architectures with small pores have been shown to confine cells and induce aggressive collective migration, irrespective of matrix stiffness and density. However, it remains unclear how cells sense collagen architecture and transduce this information to initiate collective migration. Here, we tune collagen architecture and analyze its effect on four core cell-ECM interactions: cytoskeletal polymerization, adhesion, contractility, and matrix degradation. From this comprehensive analysis, we deduce that matrix architecture initially modulates cancer cell adhesion strength, and that this results from architecture-induced changes to matrix degradability. That is, architectures with smaller pores are less degradable, and degradability is required for cancer cell adhesion to 3D fibrilar collagen. The biochemical consequences of this 3D low-attachment state are similar to those induced by suspension culture, including metabolic and oxidative stress. One distinction from suspension culture is the induction of collagen catabolism that occurs in 3D low-attachment conditions. Cells also upregulate Snail1 and Notch signaling in response to 3D low-attachment, which suggests a mechanism for the emergence of collective behaviors.
Clinical experience with new formulation SUBA®-itraconazole for prophylaxis in patients undergoing stem cell transplantation or treatment for haematological malignancies
Authors: Nield Blake , Larsen Stephen R , van Hal Sebastiaan J 
Published: June 2019

AbstractBackgroundSUper BioAvailability-itraconazole (SUBA®-itraconazole) was introduced into Australia in April 2014 as a substitute for standard itraconazole on the basis of improved bioavailability, tolerance and interpatient variability. Shortly after its introduction, our centre converted to the novel formulation for mould prophylaxis in patients undergoing allogeneic HSCT, autologous HSCT or treatment for haematological malignancies with an intermediate/high risk of invasive fungal infection (IFI).MethodsA single-institution, investigator-initiated retrospective cohort study was conducted between June 2016 and April 2018 to assess therapeutic drug concentrations, safety and tolerability of a standard prophylactic dose of SUBA®-itraconazole.ResultsA total of 74 patients were assessed across 98 admissions with 178 measured itraconazole trough concentrations. The median duration of prophylaxis was 15.5 (1–59) days. No significant correlation was identified between trough concentrations and patient demographics including gender and weight. Drug concentrations were reduced by gastric acid suppression and diarrhoea. Therapeutic itraconazole trough concentrations (≥0.5 mg/L) were achieved at a median of 7 (95% CI = 6–8) days, with 87% of patients achieving therapeutic concentrations at day 14 (expected steady-state). One (1%) proven/probable IFI and 5 (5%) possible breakthrough IFIs were identified. Although adverse events were experienced by 42% of the cohort, only a single event was directly attributable to SUBA®-itraconazole, resulting in change of prophylactic agent.ConclusionsSUBA®-itraconazole achieved rapid therapeutic trough concentrations, was associated with low rates of IFI and was well tolerated in the study population. This formulation should be considered a realistic and safe first-line agent for the prevention of IFIs in those undergoing HSCT and intermediate/high-risk therapy for haematological malignancies.
Emotional, cognitive and social factors of antimicrobial prescribing: can antimicrobial stewardship intervention be effective without addressing psycho-social factors?
Authors: Donisi V , Sibani M , Carrara E , Del Piccolo L , Rimondini M , Mazzaferri F , Bovo C , Tacconelli E 
Published: June 2019

Abstract
There is increasing evidence that psycho-social factors can influence antimicrobial prescribing practice in hospitals and the community, and represent potential barriers to antimicrobial stewardship interventions. Clinicians are conditioned both by emotional and cognitive factors based on fear, uncertainty, a set of beliefs, risk perception and cognitive bias, and by interpersonal factors established through social norms and peer and doctor–patient communication. However, a gap is emerging between research and practice, and no stewardship recommendation addresses the most appropriate human resource allocation or modalities to account for psycho-social determinants of prescribing. There is a need for translation of the evidence available from human behaviour studies to the design and implementation of stewardship interventions and policies at hospital and community levels. The integration of behaviour experts into multidisciplinary stewardship teams seems essential to positively impact on prescribers’ communication and decision-making competencies, and reduce inappropriate antibiotic prescribing.
Predicting 72-hour and 9-day return to the emergency department using machine learning
Authors: Hong Woo Suk , Haimovich Adrian Daniel , Taylor Richard Andrew 
Published: July 2019

AbstractObjectivesTo predict 72-h and 9-day emergency department (ED) return by using gradient boosting on an expansive set of clinical variables from the electronic health record.MethodsThis retrospective study included all adult discharges from a level 1 trauma center ED and a community hospital ED covering the period of March 2013 to July 2017. A total of 1500 variables were extracted for each visit, and samples split randomly into training, validation, and test sets (80%, 10%, and 10%). Gradient boosting models were fit on 3 selections of the data: administrative data (demographics, prior hospital usage, and comorbidity categories), data available at triage, and the full set of data available at discharge. A logistic regression (LR) model built on administrative data was used for baseline comparison. Finally, the top 20 most informative variables identified from the full gradient boosting models were used to build a reduced model for each outcome.ResultsA total of 330 631 discharges were available for analysis, with 29 058 discharges (8.8%) resulting in 72-h return and 52 748 discharges (16.0%) resulting in 9-day return to either ED. LR models using administrative data yielded test AUCs of 0.69 (95% confidence interval [CI] 0.68–0.70) and 0.71(95% CI 0.70–0.72), while gradient boosting models using administrative data yielded test AUCs of 0.73 (95% CI 0.72–0.74) and 0.74 (95% CI 0.73–0.74) for 72-h and 9-day return, respectively. Gradient boosting models using variables available at triage yielded test AUCs of 0.75 (95% CI 0.74–0.76) and 0.75 (95% CI 0.74–0.75), while those using the full set of variables yielded test AUCs of 0.76 (95% CI 0.75–0.77) and 0.75 (95% CI 0.75–0.76). Reduced models using the top 20 variables yielded test AUCs of 0.73 (95% CI 0.71–0.74) and 0.73 (95% CI 0.72–0.74).Discussion and ConclusionGradient boosting models leveraging clinical data are superior to LR models built on administrative data at predicting 72-h and 9-day returns.
Replicated Landscape Genomics Identifies Evidence of Local Adaptation to Urbanization in Wood Frogs
Authors: Homola Jared J , Loftin Cynthia S , Cammen Kristina M , Helbing Caren C , Birol Inanc , Schultz Thomas F , Kinnison Michael T 
Published: June 2019

AbstractNative species that persist in urban environments may benefit from local adaptation to novel selection factors. We used double-digest restriction-side associated DNA (RAD) sequencing to evaluate shifts in genome-wide genetic diversity and investigate the presence of parallel evolution associated with urban-specific selection factors in wood frogs (Lithobates sylvaticus). Our replicated paired study design involved 12 individuals from each of 4 rural and urban populations to improve our confidence that detected signals of selection are indeed associated with urbanization. Genetic diversity measures were less for urban populations; however, the effect size was small, suggesting little biological consequence. Using an FST outlier approach, we identified 37 of 8344 genotyped single nucleotide polymorphisms with consistent evidence of directional selection across replicates. A genome-wide association study analysis detected modest support for an association between environment type and 12 of the 37 FST outlier loci. Discriminant analysis of principal components using the 37 FST outlier loci produced correct reassignment for 87.5% of rural samples and 93.8% of urban samples. Eighteen of the 37 FST outlier loci mapped to the American bullfrog (Rana [Lithobates] catesbeiana) genome, although none were in coding regions. This evidence of parallel evolution to urban environments provides a powerful example of the ability of urban landscapes to direct evolutionary processes.
Methods to quantify primary plant cell wall mechanics
Authors: Bidhendi Amir J , Geitmann Anja 
Published: June 2019

AbstractThe primary plant cell wall is a dynamically regulated composite material of multiple biopolymers that forms a scaffold enclosing the plant cells. The mechanochemical make-up of this polymer network regulates growth, morphogenesis, and stability at the cell and tissue scales. To understand the dynamics of cell wall mechanics, and how it correlates with cellular activities, several experimental frameworks have been deployed in recent years to quantify the mechanical properties of plant cells and tissues. Here we critically review the application of biomechanical tool sets pertinent to plant cell mechanics and outline some of their findings, relevance, and limitations. We also discuss methods that are less explored but hold great potential for the field, including multiscale in silico mechanical modeling that will enable a unified understanding of the mechanical behavior across the scales. Our overview reveals significant differences between the results of different mechanical testing techniques on plant material. Specifically, indentation techniques seem to consistently report lower values compared with tensile tests. Such differences may in part be due to inherent differences among the technical approaches and consequently the wall properties that they measure, and partly due to differences between experimental conditions.
Principles of Therapeutic Change
Authors: Papiasvili Eva D. 
Published: June 2019

Abstract
This chapter describes how the author would implement each of the empirically based principles of change identified in Chapter 2, as they specific related to the three cases of social anxiety presented in Chapter 8. The chapter begins with the author’s initial reaction to the list of principles, as well as to the task of describing their implementation in her day-to-day clinical work. Also included in the chapter are the author’s case formulation and treatment for each case, which serve as the general context for the author’s detailed explanation of why and how she would apply the principles in ways that are best attuned to the needs of particular clients. The chapter ends with the description of the author’s thoughts and experience about writing this chapter.
Genetic variation in dopamine availability modulates the self-reported level of action control in a sex-dependent manner
Authors: Schlüter Caroline , Arning Larissa , Fraenz Christoph , Friedrich Patrick , Pinnow Marlies , Güntürkün Onur , Beste Christian , Ocklenburg Sebastian , Genc Erhan 
Published: July 2019

Abstract
Although procrastination is a widespread phenomenon with significant influence on our personal and professional life, its genetic foundation is somewhat unknown. An important factor that influences our ability to tackle specific goals directly instead of putting them off is our ability to initiate cognitive, motivational and emotional control mechanisms, so-called metacontrol. These metacontrol mechanisms have been frequently related to dopaminergic signaling. To gain deeper insight into the genetic components of procrastination, we examined whether genetically induced differences in the dopaminergic system are associated with interindividual differences in trait-like procrastination, measured as decision-related action control (AOD). Analyzing the data of 278 healthy adults, we found a sex-dependent effect of TH genotype on AOD. Interestingly, only in women, T-allele carriers showed lower AOD values and were therefore more likely to procrastinate. Additionally, we investigated whether differences in the morphology and functional connectivity of the amygdala that were previously associated with AOD happen to be related to differences in the TH genotype and thus to differences in the dopaminergic system. However, there was no significant amygdala volume or connectivity difference between the TH genotype groups. Therefore, this study is the first to suggest that genetic, anatomical and functional differences affect trait-like procrastination independently.
Creating crony capitalism: neoliberal globalization and the fueling of corruption
Authors: Reinsberg Bernhard , Kentikelenis Alexander , Stubbs Thomas 
Published: June 2019

Abstract
This article examines how neoliberal policies mandated by the International Monetary Fund (IMF) impact on corruption in developing countries. Combining domestic political analysis with world systems and dependency theories, we hypothesize that these reforms concentrate losses on influential social groups such as businesses and civil servants, who then engage in corrupt practices to maintain their privileged positions. Using an original dataset of IMF policy reforms from 1980 to 2014, we find robust empirical support for our argument. Results of regression-based analysis demonstrate an effect of IMF policy reforms that hold across multiple samples and measure of corruption: 141 countries using a corruption control measure from the International Country Risk Guide; 70 countries on the Business Environment and Enterprise Performance Survey; and 19 countries from the International Crime Victims Survey. Our findings elucidate the link between neoliberal globalization and political capitalism, while offering important policy lessons regarding the design of IMF policy reforms.
Effect of Adding Dexmedetomidine to Local Anesthetic Agents for Transversus Abdominis Plane Block
Authors: Bansal Prannal , Garg Shashank 
Published: June 2019

Background:
Dexmedetomidine (Dex) has been used as an adjuvant in transversus abdominis plane (TAP) blocks. This meta-analysis was aimed at evaluating the effect of Dex in TAP blocks.

Objectives:
Outcome measures were total opiate consumption in 24 hours after surgery, time to systemic rescue analgesia, pain scores after surgery, and adverse events (AEs).

Materials and Methods:
Randomized controlled trials comparing Dex with local anesthetics to local anesthetics alone for analgesia after abdominal surgeries were included. Standardized mean difference (SMD) and mean difference (MD) were used for continuous variables and odds ratio for frequency data.

Results:
Analysis of data from 9 randomized controlled trials (598 patients) showed that the addition of Dex to LAs decreased opiate use in 24 hours after surgery (SMD, −3.07; 95% confidence interval [CI], −4.78 to −1.35), increased time to rescue analgesia (171.8 min; 95% CI, 112.34-231.26), and decreased pain scores (scale of 0 to 10) at 4 hours (MD, −0.36; 95% CI, −0.65 to −0.07) and 8 hours (MD, −0.17; 95% CI, −0.29 to −0.04) after surgery. Frequency of adverse events was similar between the 2 groups (odds ratio, 1; 95% CI, 0.61-1.63). The estimates for pain scores were prone to sensitivity analysis. The estimates for postoperative opiate use, time to rescue analgesia, and pain scores at 8 hours had significant heterogeneity.

Conclusions:
The addition of Dex to LAs in the TAP block for analgesia after abdominal surgeries decreased 24-hour opiate use and increased the overall time to rescue analgesia including certain subgroups without increasing adverse events. Its effect on postoperative pain scores was not as definitive.