bluuebunny/crossref_metadata_2025_split huggingface dataset:
Running Performance and Position is Not Related to Decision-Making Accuracy in Referees
Authors: Riiser Amund , Andersen Vidar , Sæterbakken Atle , Ylvisaker Einar , Moe Vegard Fusche 
Published: August 2019

AbstractWe aimed to assess if running performance is related to decision-making accuracy in referees. We also investigated the relationships between movement, position, decision-making and time of infringement. The study included 347 free kicks and penalties awarded during all 15 home field matches for one team in the Norwegian top league. Movement and position were measured by a radio-based positioning system, and two external experts analysed the video clips. The referees made the correct decision in 98% of the assessed foul situations. There were no associations between the correctness and running speed at the time of the infringements or total distance accumulated during the 30 s prior to the infringement (p>0.08). Decision-making accuracy was not associated with the referees’ position in relation to the infringements (p=0.82) or the area where the infringements occurred (p=0.28). Most foul play incidents were sanctioned in the central area of the field (84%) where the distance to the infringements was shorter (13.4 m, 95% CI 12.8–14.0) than in the lateral areas (21.9 m, 95% CI 20.4–23.4). Norwegian top referees were practically always right when they interfered, possess the necessary fitness to avoid fatigue that would influence decision-making accuracy, and maintain adequate positional ability throughout the matches.
Multiple Sklerose und Fettsäuren – historischer und aktueller Studienstand
Authors: Schmiedel Volker 
Published: August 2019

ZusammenfassungSchon in den 1950er-Jahren gab es Hinweise auf Zusammenhänge zwischen Fettsäuren in der Ernährung und Multipler Sklerose (MS). In den kommenden Jahrzehnten
konnte dann aufgedeckt werden, über welche Mechanismen bestimmte Fettsäuren pro- oder anti-inflammatorisch wirken. Weitere Studien konnten belegen, dass die
Omega-3-Fettsäuren EPA/DHA Entzündungsmediatoren senken können. Weitere Symptome wie Depression, Schübe oder Stoffwechselparameter konnten laut Studien
ebenfalls gebessert werden.
Den Flow erleben: Therapeutisches Klettern bei Multipler Sklerose
Authors: Kern Claudia 
Published: August 2019

ZusammenfassungEs ist immer noch ein ungewöhnliches Bild, wenn die Teilnehmer der Klettergruppe „MS on the Rocks“ im Rollstuhl oder mit Gehhilfen in der Kletterhalle der TU
München ankommen. Am Campus im Olympiapark wird seit fast 15 Jahren gezeigt, wie Menschen, die an Multipler Sklerose (MS) erkrankt sind, durch das Klettern
nachhaltig körperlich aktiv werden und neuen Lebensmut bekommen.Der Beitrag fasst anhand des Forschungsstandes die Effekte des Therapeutischen Kletterns bei MS zusammen. Ein Fallbeispiel zeigt exemplarisch die positiven
Einflüsse auf psychischer, sozialer und körperlicher Ebene.
Clinical Information Systems and Artificial Intelligence: Recent Research Trends
Authors: Combi Carlo , Pozzi Giuseppe 
Published: August 2019

Objectives: This survey aims at reviewing the literature related to Clinical Information Systems (CIS), Hospital Information Systems (HIS), Electronic Health Record (EHR) systems, and how collected data can be analyzed by Artificial Intelligence (AI) techniques.
Methods: We selected the major journals (11 journals) collecting papers (more than 7,000) over the last five years from the top members of the research community, and read and analyzed the papers (more than 200) covering the topics. Then, we completed the analysis using search engines to also include papers from major conferences over the same five years.
Results: We defined a taxonomy of major features and research areas of CIS, HIS, EHR systems. We also defined a taxonomy for the use of Artificial Intelligence (AI) techniques on healthcare data. In the light of these taxonomies, we report on the most relevant papers from the literature.
Conclusions: We highlighted some major research directions and issues which seem to be promising and to need further investigations over a medium- or long-term period.
Managing Complexity. From Documentation to Knowledge Integration and Informed Decision Findings from the Clinical Information Systems Perspective for 2018
Authors: Hackl Werner O. , Hoerbst Alexander ,   Section Editors for the IMIA Yearbook Section on Clinical Information Systems
Published: August 2019

Objective: To summarize recent research and to propose a selection of best papers published in 2018 in the field of Clinical Information Systems (CIS).
Method: Each year a systematic process is carried out to retrieve articles for the CIS section of the IMIA Yearbook of Medical Informatics and to select a set of pest papers for the section. The same query as in the last five years was used. The retrieved articles were categorized in a multi-pass review carried out by the two section editors. The final selection of candidate papers was then peer-reviewed by Yearbook editors and external reviewers. Based on the review results the best papers were then chosen at the selection meeting with the IMIA Yearbook editorial board. Text mining, and term co-occurrence mapping techniques were again used to get an overview of the content of the retrieved articles.
Results: The query was carried out in mid-January 2019, yielding a consolidated, deduplicated result set of 2,264 articles which had been published in 957 different journals. This year, we nominated twelve papers as candidates and three of them were finally selected as best papers in the CIS section. Again, the content analysis of the articles revealed the broad spectrum of topics which is covered by CIS research.
Conclusions: We could observe ongoing trends from our 2017 analysis. The patient increasingly moves in the focus of the research activities and trans-institutional aggregation of data is still an important field of work. The move to use patient and other clinical data directly for the patient and to support data driven process management, the move away from clinical documentation to patient-focused knowledge generation and support of informed decision, is gaining momentum by the application of new or already known but, due to technological advances, now applicable methodological approaches.
Artificial Intelligence in Health in 2018: New Opportunities, Challenges, and Practical Implications
Authors: Jackson Gretchen , Hu Jianying ,   Section Editors for the IMIA Yearbook Section on Artificial Intelligence in Health
Published: August 2019

Objective: To summarize significant research contributions to the field of artificial intelligence (AI) in health in 2018.
Methods: Ovid MEDLINE® and Web of Science® databases were searched to identify original research articles that were published in the English language during 2018 and presented advances in the science of AI applied in health. Queries employed Medical Subject Heading (MeSH®) terms and keywords representing AI methodologies and limited results to health applications. Section editors selected 15 best paper candidates that underwent peer review by internationally renowned domain experts. Final best papers were selected by the editorial board of the 2018 International Medical Informatics Association (IMIA) Yearbook.
Results: Database searches returned 1,480 unique publications. Best papers employed innovative AI techniques that incorporated domain knowledge or explored approaches to support distributed or federated learning. All top-ranked papers incorporated novel approaches to advance the science of AI in health and included rigorous evaluations of their methodologies.
Conclusions: Performance of state-of-the-art AI machine learning algorithms can be enhanced by approaches that employ a multidisciplinary biomedical informatics pipeline to incorporate domain knowledge and can overcome challenges such as sparse, missing, or inconsistent data. Innovative training heuristics and encryption techniques may support distributed learning with preservation of privacy.
A Year of Papers Using Biomedical Texts: Findings from the Section on Natural Language Processing of the IMIA Yearbook
Authors: Grabar Natalia , Grouin Cyril ,   Section Editors for the IMIA Yearbook Section on Natural Language Processing
Published: August 2019

Objectives: To analyze the content of publications within the medical Natural Language Processing (NLP) domain in 2018.
Methods: Automatic and manual pre-selection of publications to be reviewed, and selection of the best NLP papers of the year. Analysis of the important issues.
Results: Two best papers have been selected this year. One dedicated to the generation of multi- documents summaries and another dedicated to the generation of imaging reports. We also proposed an analysis of the content of main research trends of NLP publications in 2018.
Conclusions: The year 2018 is very rich with regard to NLP issues and topics addressed. It shows the will of researchers to go towards robust and reproducible results. Researchers also prove to be creative for original issues and approaches.
Advancing Artificial Intelligence in Sensors, Signals, and Imaging Informatics
Authors: Hsu William , Baumgartner Christian , Deserno Thomas ,   Section Editors for the IMIA Yearbook Section on Sensors, Signals, and Imaging Informatics
Published: August 2019

Objective: To identify research works that exemplify recent developments in the field of sensors, signals, and imaging informatics.
Method: A broad literature search was conducted using PubMed and Web of Science, supplemented with individual papers that were nominated by section editors. A predefined query made from a combination of Medical Subject Heading (MeSH) terms and keywords were used to search both sources. Section editors then filtered the entire set of retrieved papers with each paper having been reviewed by two section editors. Papers were assessed on a three-point Likert scale by two section editors, rated from 0 (do not include) to 2 (should be included). Only papers with a combined score of 2 or above were considered.
Results: A search for papers was executed at the start of January 2019, resulting in a combined set of 1,459 records published in 2018 in 119 unique journals. Section editors jointly filtered the list of candidates down to 14 nominations. The 14 candidate best papers were then ranked by a group of eight external reviewers. Four papers, representing different international groups and journals, were selected as the best papers by consensus of the International Medical Informatics Association (IMIA) Yearbook editorial board.
Conclusions: The fields of sensors, signals, and imaging informatics have rapidly evolved with the application of novel artificial intelligence/machine learning techniques. Studies have been able to discover hidden patterns and integrate different types of data towards improving diagnostic accuracy and patient outcomes. However, the quality of papers varied widely without clear reporting standards for these types of models. Nevertheless, a number of papers have demonstrated useful techniques to improve the generalizability, interpretability, and reproducibility of increasingly sophisticated models.
Utility of Regional Anesthesia in Extremity Reconstruction
Authors: Weisberger Joseph S. , Oleck Nicholas C. , Ayyala Haripriya S. , Dalena Margaret M. , Lee Edward S. 
Published: August 2019

Background Regional anesthesia (RA) may help to circumvent the well-documented risks associated with general anesthesia, increase patient comfort and satisfaction, and mitigate costs. This study aims to investigate the utility of RA in extremity reconstruction.
Methods The American College of Surgeons National Surgical Quality Improvement Program database was queried for all cases of extremity reconstruction including muscle, myocutaneous, or fasciocutaneous flaps from 2005 to 2016. Two groups were created based on anesthesia technique, regional/epidural and general. Postoperative complications included reoperation, readmission, and wound complications. Propensity score matching was utilized to control for variation in sample size, significant comorbidities, and demographics in the analysis of complications.
Results A total of 2,874 cases were identified with general anesthesia utilized in 2,820 cases and RA in the remaining 54. After propensity score matching, 53 cases were identified in each group. In both unmatched and matched cohorts, there was no statistically significant difference in the rates of reoperation, readmission, or wound complication rates. In the matched cohort, mean operative time in the RA cohort was significantly shorter, 157.64 (±112.36) minutes compared with 293.06 minutes (±201.35 minutes) in the general anesthesia group (p < 0.001). While no statistically significant difference was detected in mean length of stay (LOS) between the two groups, the RA group experienced a clinically significant shorter LOS of 5.77 days (±5.87 days) compared with 7.02 (±5.61) days in the general anesthesia group (p = 0.269).
Conclusion RA may be a safe, reasonable alternative to general anesthesia in extremity reconstruction without increase in postoperative complications. Additionally, RA use is associated with a significant reduction in operative time, potentially leading to shorter and safer procedures without compromising outcomes.
CPEB3 inhibits translation of mRNA targets by localizing them to P bodies
Authors: Ford Lenzie , Ling Emi , Kandel Eric R. , Fioriti Luana 
Published: August 2019

Significance
Deciphering how cells regulate compartmentalization is critical for our understanding of local protein synthesis-dependent mechanisms, such as learning and memory. One way to achieve compartmentalization is by means of liquid–liquid phase separation, which results in the formation of membraneless organelles such as P bodies. In this study, we investigated how the cell regulates the inhibitory effect of the translation regulator cytoplasmic polyadenylation element-binding protein 3 (CPEB3), by means of small ubiquitin-like modifier (SUMO)ylation and localization to P bodies. Our findings on the role of SUMO as a critical mediator of CPEB3 phase separation might be relevant also in the context of the aberrant phase separation that characterizes other RNA-binding proteins implicated in neurodegenerative diseases, such as FUS (fused in sarcoma) and TDP-43 (TAR DNA binding protein 43) in ALS (amyotrophic lateral sclerosis).
Nucleosome positions alone can be used to predict domains in yeast chromosomes
Authors: Wiese Oliver , Marenduzzo Davide , Brackley Chris A. 
Published: August 2019

Significance
DNA is packaged into chromosomes, which are further organized into domains: Regions of the genome which are more likely to self-interact. Domains have been observed in species ranging from bacteria to humans and are thought to play an important role in gene regulation. Yet the mechanisms of domain formation are not fully understood. Here we use computer simulations to investigate domain formation in yeast. Our model reproduces the experimentally observed domains using only nucleosome positioning information as an input, implying that (unlike in higher eukaryotes) domain boundary locations are largely determined at this level. Our results reveal how irregular nucleosome spacing impacts the 3D chromosome organization, pointing to a direct link between nucleosome positioning and genome regulation at the large scale.
Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction
Authors: Totaro Antonio , Zhuang Qiuyu , Panciera Tito , Battilana Giusy , Azzolin Luca , Brumana Giulia , Gandin Alessandro , Brusatin Giovanna , Cordenonsi Michelangelo , Piccolo Stefano 
Published: August 2019

Significance
We describe the convergence of autophagy with YAP/TAZ, 2 highly related transcriptional regulators playing essential roles in cell plasticity for tissue regeneration and cancer. We show that a key event in autophagy, the fusion of autophagosomal vesicles with lysosomes, is transcriptionally regulated by YAP/TAZ. At least in part, this is mediated by the YAP/TAZ target Armus, a protein of the RAB-GAP family. Consistently with YAP/TAZ being patterned by mechanical signals, we found that cellular mechanics, dictated by the physical properties of the ECM, potently regulate autophagy efficiency. The connection described here is crucial for YAP-mediated reprogramming of normal cells into stem-like cells and of benign tumor cells in cancer stem cells. Thus, nuclear reprogramming must go hand in hand with autophagy-mediated cytoplasmic restructuring.
Rapid weight loss influences the physical, psychological and biological responses during a simulated competition in national judo athletes
Authors: Isacco Laurie , Degoutte Fabrice , Ennequin Gaël , Pereira Bruno , Thivel David , Filaire Edith 
Published: August 2019

AbstractThe effect of rapid energy restriction‐induced weight loss on judo‐related performance remains unclear, and there is a paucity of information regarding the influence of the fight successions during competition. Thus, the aim of this study was to compare the cumulative effect of judo fights on physical performance, biological and psychological profiles, of national judo competitors with vs without rapid weight loss. After one month of weight maintenance (Baseline), 20 subjects were randomly divided into two groups the week before a simulated competition: (i) a Weight Loss group (WL; weight loss ≥ 3% of body mass); (ii) a Weight Stable group (WS). The simulated competition was composed of five fights (F1 to F5) separated by 30 min rest. Anthropometric assessments were performed at baseline and on the morning of the simulated competition (T0). Psychological, biological and physical assessments (maximal handgrip strength, upper limb anaerobic capacity) were performed at T0 and after each fight. The variation of body mass between baseline and T0 was significantly different between groups (+1.2% vs −3%; p < .01). The dimensions of the Profile of Mood State questionnaire, the rate of perceived exertion, ammonia, urea and free fatty acid concentrations, maximal strength and time sustained at maximal strength showed a significant group x time interaction at F4 and F5. The study shows that cumulative fights lead to uncoupled responses in physical, psychological and biological parameters in judo competitors who underwent or not rapid weight loss. Specific recovery strategies in terms of nutrition and active recovery should be considered.
50 years change in urban land use and ecological planning globally in the era of design with nature
Authors: Douglas Ian 
Published: August 2019

ABSTRACT

Ian McHarg’s 1969 book,
Design with Nature
, was grounded in earlier good practice, especially the European vision of fitting cities into the regional landscape and carrying thorough surveys before planning commenced. The book emerged in the wake of publications that worried about the ability of the earth to support expanding populations and their growing impact on the environment. McHarg argued that ecological design should follow planning based on detailed site information. Although McHarg advised many urban authorities in the USA and other countries, especially in Africa, Asia and Europe, and his ideas had influenced some British new towns, they had little attention in the planning of Milton Keynes, England’s largest new urban settlement, where the initial geological surveys were inadequate, but a successful large tree-planting program has created a “city in the forest.” McHarg was however closely involved in planning the Nigerian Capital city, Abuja, but his sound master plan was ill-equipped to provide for a nation undergoing post-conflict rebuilding and a local population more concerned with access to land than ecological planning. Nonetheless, McHarg helped us to promote, protect, and preserve urban green spaces. Although teams from different disciplines now work well together, the integrated thinking advocated by McHarg remains sometimes in short supply in local practice.
Advances in new generation diluted magnetic semiconductors with independent spin and charge doping
Authors: Zhao Guoqiang , Deng Zheng , Jin Changqing 
Published: August 2019

Abstract
As one branch of spintronics, diluted magnetic semiconductors (DMSs) are extensively investigated due to their fundamental significance and potential application in modern information society. The classical materials (Ga,Mn)As of III–V group based DMSs has been well studied for its high compatibility with the high-mobility semiconductor GaAs. But the Curie temperature in (Ga,Mn)As film is still far below room temperature because the spin & charge doping is bundled to the same element that makes the fabrication very difficult. Alternatively, the discovery of a new generation DMSs with independent spin and charge doping, such as (Ba,K)(Zn,Mn) 2As2 (briefly named BZA), attracted considerable attention due to their unique advantages in physical properties and heterojunction fabrication. In this review we focus on this series of new DMSs including (I) materials in terms of three types of new DMSs, i.e. the " 111”, " 122” and " 1111” system; (II) the physical properties of BZA; (III) single crystals & prototype device based on BZA. The prospective of new type of DMSs with independent spin and charge doping is briefly discussed.
Amorphous magnetic semiconductors with Curie temperatures above room temperature
Authors: Chen Na , Fang Kaixuan , Zhang Hongxia , Zhang Yingqi , Liu Wenjian , Yao Kefu , Zhang Zhengjun 
Published: August 2019

Abstract
Recently, amorphous magnetic semiconductors as a new family of magnetic semiconductors have been developed by oxidizing ferromagnetic amorphous metals/alloys. Intriguingly, tuning the relative atomic ratios of Co and Fe in a Co-Fe-Ta-B-O system leads to the formation of an intrinsic magnetic semiconductor. Starting from high Curie-temperature amorphous ferromagnets, these amorphous magnetic semiconductors show Curie temperatures well above room temperature. Among them, one typical example is a p-type Co28.6Fe12.4Ta4.3B8.7O46 magnetic semiconductor, which has an optical bandgap of ~2.4 eV, room-temperature saturation magnetization of ~433 emu/cm3, and the Curie temperature above 600 K. The amorphous Co28.6Fe12.4Ta4.3B8.7O46 magnetic semiconductor can be integrated with n-type Si to form p–n heterojunctions with a threshold voltage of ~1.6 V, validating its p-type semiconducting character. Furthermore, the demonstration of electric field control of its room-temperature ferromagnetism reflects the interplay between the electricity and ferromagnetism in this material. It is suggested that the carrier density, ferromagnetism and conduction type of an intrinsic magnetic semiconductor are controllable by means of an electric field effect. These findings may pave a new way to realize magnetic semiconductor-based spintronic devices that work at room temperature.