bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-country comparison of strategies for building consumer trust in food
Authors: Wilson Annabelle M , Tonkin Emma , Coveney John , Meyer Samantha B , McCullum Dean , Calnan Michael , Kelly Edel , O’Reilly Seamus , McCarthy Mary , McGloin Aileen , Ward Paul R 
Published: March 2019

Summary
Consumer trust in the modern food system is essential given its complexity. Contexts vary across countries with regard to food incidents, regulation and systems. It is therefore of interest to compare how key actors in different countries might approach (re)building consumer trust in the food system; and particularly relevant to understanding how food systems in different regions might learn from one another. The purpose of this paper is to explore differences between strategies for (re)building trust in food systems, as identified in two separate empirical studies, one conducted in Australia, New Zealand and the UK (Study 1) and another on the Island of Ireland (Study 2). Interviews were conducted with media, food industry and food regulatory actors across the two studies (n = 105 Study 1; n = 50 Study 2). Data were coded into strategy statements, strategies describing actions to (re)build consumer trust. Strategy statements were compared between Studies 1 and 2 and similarities and differences were noted. The strategy statements identified in Study 1 to (re)build consumer trust in the food system were shown to be applicable in Study 2, however, there were notable differences in the contextual factors that shaped the means by which strategies were implemented. As such, the transfer of such approaches across regions is not an appropriate means to addressing breaches in consumer trust. Notwithstanding, our data suggest that there is still capacity to learn between countries when considering strategies for (re)building trust in the food system but caution must be exercised in the transfer of approaches.
Non-communicable disease prevention in Mexico: policies, programs and regulations
Authors: Aceves Benjamin , Ingram Maia , Nieto Claudia , de Zapien Jill Guernsey , Rosales Cecilia 
Published: March 2019

Abstract
Non-communicable diseases (NCD), such as diabetes and cardiovascular disease, have become a leading cause of the death in Mexico. The federal government has addressed this issue through developing NCD prevention plans, regulations and policies (PRPs) that seek to address social and environmental factors, which was led by the National Institute of Public Health and Ministry of Health in concert with various non-governmental organizations. This review aims to synthesize and summarize national NCD prevention PRPs addressing social and environmental factors passed from 2010 to 2016, and to assess the extent to which these efforts successfully addressed factors contributing to the epidemic. In total nine federal NCD prevention PRPs were identified from a scan that examined executive and legislative PRPs, which identified five documents. A scoping review was conducted for evaluation studies and reports corresponding to these PRPs. The majority of PRPs focused on nutrition, specifically the access and promotion of food. Studies and reports demonstrated that taxation on energy-dense low-nutrient foods and sugar-sweetened beverages were the most effective. Other PRPs had various issues with implementation, mostly related to adherence and resources available. Overall, there lacked evidence of evaluative work on several NCD prevention PRPs, specifically assessing implementation and effectiveness. Additionally, PRPs did not sufficiently address integration of clinical, social, environmental approaches and access to physical activity. While the Mexican federal government has taken the initial steps to address the multifactorial causes of NCD, firm political commitment and investment of significant resources are still needed.
Stick or Slip: Adhesive Performance of Geckos and Gecko-Inspired Synthetics in Wet Environments
Authors: Stark Alyssa Y , Mitchell Christopher T 
Published: March 2019

AbstractThe gecko adhesive system has inspired hundreds of synthetic mimics principally focused on replicating the strong, reversible, and versatile properties of the natural system. For geckos native to the tropics, versatility includes the need to remain attached to substrates that become wet from high humidity and frequent rain. Paradoxically, van der Waals forces, the principal mechanism responsible for gecko adhesion, reduce to zero when two contacting surfaces separate even slightly by entrapped water layers. A series of laboratory studies show that instead of slipping, geckos maintain and even improve their adhesive performance in many wet conditions (i.e., on wet hydrophobic substrates, on humid substrates held at low temperatures). The mechanism for this is not fully clarified, and likely ranges in scale from the chemical and material properties of the gecko’s contact structures called setae (e.g., setae soften and change surface confirmation when exposed to water), to their locomotor biomechanics and decision-making behavior when encountering water on a substrate in their natural environment (e.g., some geckos tend to run faster and stop more frequently on misted substrates than dry). Current work has also focused on applying results from the natural system to gecko-inspired synthetic adhesives, improving their performance in wet conditions. Gecko-inspired synthetic adhesives have also provided a unique opportunity to test hypotheses about the natural system in semi-natural conditions replicated in the laboratory. Despite many detailed studies focused on the role of water and humidity on gecko and gecko-inspired synthetic adhesion, there remains several outstanding questions: (1) what, if any, role does capillary or capillary-like adhesion play on overall adhesive performance of geckos and gecko-inspired synthetics, (2) how do chemical and material changes at the surface and in the bulk of gecko setae and synthetic fibrils change when exposed to water, and what does this mean for adhesive performance, and (3) how much water do geckos encounter in their native environment, and what is their corresponding behavioral response? This review will detail what we know about gecko adhesion in wet environments, and outline the necessary next steps in biological and synthetic system investigations.
Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: a record linkage study of 1.1 million people in England
Authors: Chan Mei Sum , van den Hout Ardo , Pujades-Rodriguez Mar , Jones Melvyn Mark , Matthews Fiona E , Jagger Carol , Raine Rosalind , Bajekal Madhavi 
Published: March 2019

Abstract

Background
Age of onset of multimorbidity and its prevalence are well documented. However, its contribution to inequalities in life expectancy has yet to be quantified.

Methods
A cohort of 1.1 million English people aged 45 and older were followed up from 2001 to 2010. Multimorbidity was defined as having 2 or more of 30 major chronic diseases. Multi-state models were used to estimate years spent healthy and with multimorbidity, stratified by sex, smoking status and quintiles of small-area deprivation.

Results
Unequal rates of multimorbidity onset and subsequent survival contributed to higher life expectancy at age 65 for the least (Q1) compared with most (Q5) deprived: there was a 2-year gap in healthy life expectancy for men [Q1: 7.7 years (95% confidence interval: 6.4–8.5) vs Q5: 5.4 (4.4–6.0)] and a 3-year gap for women [Q1: 8.6 (7.5–9.4) vs Q5: 5.9 (4.8–6.4)]; a 1-year gap in life expectancy with multimorbidity for men [Q1: 10.4 (9.9–11.2) vs Q5: 9.1 (8.7–9.6)] but none for women [Q1: 11.6 (11.1–12.4) vs Q5: 11.5 (11.1–12.2)]. Inequalities were attenuated but not fully attributable to socio-economic differences in smoking prevalence: multimorbidity onset was latest for never smokers and subsequent survival was longer for never and ex smokers.

Conclusions
The association between social disadvantage and multimorbidity is complex. By quantifying socio-demographic and smoking-related contributions to multimorbidity onset and subsequent survival, we provide evidence for more equitable allocation of prevention and health-care resources to meet local needs.
Nontrivial Elements in a Knot Group That are Trivialized by Dehn Fillings
Authors: Ito Tetsuya , Motegi Kimihiko , Teragaito Masakazu 
Published: March 2019

AbstractLet $K$ be a nontrivial knot in $S^3$ with the exterior $E(K)$, and $\gamma \in G(K) = \pi _1(E(K), *)$ a slope element represented by an essential simple closed curve on $\partial E(K)$ with base point $* \in \partial E(K)$. Since the normal closure $\langle \!\langle \gamma \rangle \!\rangle $ of $\gamma $ in $G(K)$ coincides with that of $\gamma ^{-1}$, and $\gamma $ and $\gamma ^{-1}$ correspond to a slope $r \in \mathbb{Q} \cup \{ \infty \}$, we write $\langle \!\langle r \rangle \!\rangle = \langle \!\langle \gamma \rangle \!\rangle $. The normal closure $\langle \!\langle r \rangle \!\rangle $ describes elements, which are trivialized by $r$-Dehn filling of $E(K)$. In this article, we prove that $\langle \!\langle r_1 \rangle \!\rangle = \langle \!\langle r_2 \rangle \!\rangle $ if and only if $r_1 = r_2$, and for a given finite family of slopes $\mathcal{S} = \{ r_1, \dots , r_n \}$, the intersection $\langle \!\langle r_1 \rangle \!\rangle \cap \cdots \cap \langle \!\langle r_n \rangle \!\rangle $ contains infinitely many elements except when $K$ is a $(p, q)$-torus knot and $pq \in \mathcal{S}$. We also investigate inclusion relation among normal closures of slope elements.
Gender inequity as a barrier to women’s access to skilled pregnancy care in rural Nigeria: a qualitative study
Authors: Yaya Sanni , Okonofua Friday , Ntoimo Lorretta , Udenige Ogochukwu , Bishwajit Ghose 
Published: March 2019

Abstract

Background
Maternal mortality has been an issue of global importance, with continued efforts by the international development community towards its reduction. The provision of high quality maternal healthcare has been identified as a key strategy in preventing maternal mortality. Gendered intrahousehold power structures, gendered dynamics of resource allocation and women’s limited ability in decision-making can have a huge impact on maternal health-seeking behaviour and overall health status. Using a gender lens, this study explores the root causes of women’s limited access to and utilisation of maternal healthcare services in rural areas of Edo State, Nigeria.

Methods
This qualitative study involved the analysis of data collected from gender- and age-desegregated focus group discussions (FDGs) in 20 communities in Etsako East and Esan South East local government areas of Edo State, Nigeria. Focus group participants comprised women between the ages of 15–45 y who have been pregnant within the last 5 y and their male spouses and partners of varying ages. A total of 20 FGDs were conducted. Coded transcripts were reviewed and analysed using the gender framework as an analytical guide.

Results
Most responses indicated that women did not entirely have the power to make decisions regarding when to seek care during pregnancy. Women’s experiences of access to quality care showed intersecting areas of gender and social economic status (SES) and how they impact on access to health. Many of the responses suggested high levels of economic marginalisation among women with women being financially dependent on their spouses and partners for pregnancy healthcare-related costs. Furthermore, a man’s financial status determined the type of care his spouse or partner sought. Women identified a high workload as an issue during pregnancy and a barrier to accessing maternal healthcare services. The role of men within households was generally perceived as that of financial providers, therefore a husband’s support was commonly constructed to solely mean financial support.

Conclusion
This paper brings attention to the role of gender and SES in producing and sustaining limitations to women’s access to quality care. Interventions geared towards supporting women’s financial independence is an important step towards improving their access to skilled healthcare, more so are interventions that improve women’s decision-making capacities.
Intrapulmonary pharmacokinetics of cefiderocol, a novel siderophore cephalosporin, in healthy adult subjects
Authors: Katsube Takayuki , Saisho Yutaka , Shimada Jingoro , Furuie Hidetoshi 
Published: March 2019

Abstract

Background
Cefiderocol, a novel siderophore cephalosporin, has shown potent activity against Gram-negative bacteria, including MDR pathogens. Cefiderocol is under clinical investigation for the treatment of serious Gram-negative infections including nosocomial pneumonia.

Objectives
This study assessed intrapulmonary penetration after a single intravenous dose of cefiderocol (2000 mg infused over 60 min) in healthy adult males.

Materials and methods
Each subject underwent one bronchoscopy with bronchoalveolar lavage (BAL) to collect BAL fluid (BALF). Fifteen subjects were assigned to one of three collection timepoints (1, 2 or 4 h from start of infusion). Five additional subjects were assigned to a collection timepoint at 6 h, which was added based on concentration data between 1 and 4 h predicting measurable BALF cefiderocol concentrations at 6 h.

Results
Cefiderocol concentrations in plasma, epithelial lining fluid (ELF) and alveolar macrophages (AMs) were calculated for each subject. The ELF concentration of cefiderocol was 13.8, 6.69, 2.78 and 1.38 mg/L at 1, 2, 4 and 6 h after single intravenous dosing, respectively. Over 6 h, geometric mean concentration ratios ranged from 0.0927 to 0.116 for ELF to total plasma and from 0.00496 to 0.104 for AMs to total plasma. AUC ratios of ELF and AMs to plasma were 0.101 and 0.0177 based on total drug in plasma, respectively, and 0.239 and 0.0419 based on free drug in plasma, respectively. There were no major drug-related adverse events.

Conclusions
Results of this study indicate that cefiderocol penetrates into ELF, and ELF and plasma concentrations appear to be parallel.
Bridging the integration gap between patient-generated blood glucose data and electronic health records
Authors: Lewinski Allison A , Drake Connor , Shaw Ryan J , Jackson George L , Bosworth Hayden B , Oakes Megan , Gonzales Sarah , Jelesoff Nicole E , Crowley Matthew J 
Published: March 2019

Abstract
Telemedicine can facilitate population health management by extending the reach of providers to efficiently care for high-risk, high-utilization populations. However, for telemedicine to be maximally useful, data collected using telemedicine technologies must be reliable and readily available to healthcare providers. To address current gaps in integration of patient-generated health data into the electronic health record (EHR), we examined 2 patient-facing platforms, Epic MyChart and Apple HealthKit, both of which facilitated the uploading of blood glucose data into the EHR as part of a diabetes telemedicine intervention. All patients were offered use of the MyChart platform; we subsequently invited a purposive sample of patients who used the MyChart platform effectively (n = 5) to also use the Apple HealthKit platform. Patients reported both platforms helped with diabetes self-management, and providers appreciated the convenience of the processes for obtaining patient data. Providers stated that the EHR data presentation format for Apple HealthKit was challenging to interpret; however, they also valued the greater perceived accuracy the Apple HealthKit data. Our findings indicate that patient-facing platforms can feasibly facilitate transmission of patient-generated health data into the EHR and support telemedicine-based care.
Utilizing the Hub-and-Spoke Model to Deliver Quality Breast Imaging in a Large Health System
Authors: Pham Ramya , Constantinou Niki , Plecha Donna 
Published: March 2019

Abstract
Healthcare systems are constantly expanding and gaining new territories. This growth is met with challenges in the organization and delivery of quality health care services to a large geographical area. The need for provider and staff coverage at the new sites often outpaces the rate at which additional providers and staff are hired. The need for new technology, equipment, and administrative support to oversee the new sites may also lag. The overall result could compromise patient experience at these outlying locations. The breast imaging division at University Hospitals Cleveland Medical Center (UHCMC) instituted many changes to support UHCMC’s continual growth while focusing on consistent quality of care and optimal patient experience. Changes included adoption of the hub-and-spoke organization-design model and incorporation of the integrated practice unit (IPU) concept. In the hub-and-spoke organization-design model, full services are offered at a central hub, with additional limited services provided at the peripheral spoke sites. The IPU is a dedicated team of clinical and nonclinical personnel providing the full care cycle centered on a specific medical condition such as breast health. The breast imaging hubs and spokes are incorporated into the breast health IPUs to provide uniform quality care across a large health system. The purpose of this article is to describe how the breast imaging division, functioning as members of the breast care IPU, utilized the hub-and-spoke concept to provide quality breast imaging services throughout the expanding health system.
The Heterogeneity of Tort Law
Authors: Murphy John 
Published: March 2019

Abstract
This article tests the plausibility of several leading, explanatory theories of tort by reference to the fact that tort law possesses neither the juridical nor the structural unity that the relevant theories ascribe to it. It considers a wide range of tort actions that reveal a much more heterogeneous body of law than any of the targeted theorists admit exists. It concludes that, taken together, tort law’s varying liability bases, its departures from the requirement of a rights infringement, its structural variations and its remedial diversity combine to belie the various reductionist claims the theorists in question make.
Case epidemiology from the first three years of a pilot laboratory-based surveillance system for elevated blood-lead concentrations among children in England, 2014–17: implications for public health action
Authors: Roberts D J , Crabbe Helen , Owodunni Tayo , Gordon-Brown Harriet , Close Rebecca , Reshat Shanel , Sampson Barry , Ruggles Ruth , Dabrera Gavin , Busby Araceli , Leonardi Giovanni 
Published: March 2019

Abstract

Background
Children incur lead toxicity even at low blood-lead concentrations (BLCs), and testing in England is opportunistic. We described epidemiology of cases notified to a passive laboratory-based surveillance system (SS), the Lead Poisoning in Children (LPIC) SS to inform opportunities to prevent lead exposure in children in England.

Methods
Surveillance population: children &lt;16 years of age and resident in England during the reporting period September 2014–17. Case definition: children with BLC ≥0.48 μmol/l (10 μg/dl). We extracted case demographic/location data and linked it with laboratory, area-level population and socio-economic status (SES) data. We described case BLCs and calculated age-, gender- and SES-specific notification rates, and age-sex standardised regional notification rates.

Results
Between 2014 and 2017 there were 86 newly notified cases, giving an annual average notification rate of 2.76 per million children aged 0–15 years. Regionally, rates varied from 0.36 to 9.89 per million. Rates were highest in the most deprived quintile (5.38 per million), males (3.75 per million) and children aged 1–4 years (5.89 per million).

Conclusions
Males, children aged 1–4 years, and children in deprived areas may be at higher risk, and could be targeted for primary prevention. Varied regional notification rates suggest differences in clinician awareness of lead exposure and risk factors; guidelines standardising the indications for BLC-testing may assist secondary prevention.
Are the Largest Banks Valued More Highly?
Authors: Minton Bernadette A , Stulz René M , Taboada Alvaro G 
Published: March 2019

Abstract
Some argue too-big-to-fail (TBTF) status increases the value of the largest banks. In contrast, we find that the value of the largest banks is negatively related to asset size in normal times, but much less so during the crisis. Further, shareholders lose when large banks cross a TBTF threshold through acquisitions. The negative relation between bank value and bank size for the largest banks cannot be explained by differences in ROA, ROE, equity volatility, tail risk, distress risk, or equity discount rates, but it can be partly explained by the market’s discounting of trading activities.
Received December 20, 2017; editorial decision November 14, 2018 by Editor Itay Goldstein.
High-fidelity Training Model for Measurement of Dynamic Optic Nerve Sheath Diameter Using Transorbital Ultrasonography
Authors: Hajat Zakir , Dinsmore Michael , Venkatraghavan Lashmi 
Published: March 2019

Background:
Transorbital ultrasonographic measurement of optic nerve sheath diameter (ONSD) is an important technique for bedside assessment of raised intracranial pressure (ICP). However, developing competency for this clinical skill requires practice scans on both normal subjects and patients with raised ICP. The aim of this study is to develop a high-fidelity training model capable of measuring dynamic changes in ONSD and to test the reliability and reproducibility of the model at different simulated ICP values.

Materials and Methods:
We designed and developed a high-fidelity training model for dynamic ONSD measurement using a hemispherical table tennis ball, mounted on a 3.0-mm pediatric microcuffed endotracheal tube (ETT). Two independent investigators then performed a randomized blinded study to assess the reliability and reproducibility of the model. A total of 30 ONSD measurements (10 measurements each for 3 ETT cuff volumes of 0.1, 0.2, and 0.3 mL, simulating an ONSD of a normal, borderline, and raised ICP, respectively) were performed by each investigator. Intraclass correlation coefficients and Bland-Altman plots were calculated to analyze the level of agreement between the investigators.

Results:
Our model was able to provide dynamic changes in ONSD secondary to ETT cuff volume changes. Small increments of 0.1 mL cuff volume changes produced immediate changes in ONSD that are similar to those observed in patients. The median interobserver difference in ONSD was 0.3 mm (interquartile range, 0. to 0.4 mm). Intraclass correlation coefficient was 0.89, 0.89, and 0.90 for 0.1, 0.2, and 0.3 mL ETT cuff volumes, respectively.

Conclusions:
We have developed a clinically relevant model capable of simulating changes in ONSD in patients with normal and raised ICP. This model could be a valuable training tool to gain scanning experience in optic nerve ultrasonography, and improve operators’ technical abilities.