bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mut zur Komplexität – Ein Plädoyer
Authors: Kämper Siegfried , Bierbach Elvira , Corts Magga , Kämper Harald , Stern Cornelia 
Published: June 2018

SummaryDie Herausgeber der DHZ plädieren für die Verordnung von registrierten homöopathischen Komplexmitteln, gerade weil für sie keine Indikation angegeben ist.Das Fehlen von Indikationen motiviert dazu, die Mittel auf Basis diagnostischer Kenntnisse und homöopathischen Fachwissens individuell zu verordnen. Von registrierten Komplexmitteln ist aufgrund der meist umfassenderen Zusammensetzung eine breitere Wirkung mit vielschichtigerenSynergien zu erwarten.
Interpretation und Takt
Authors: Golder Werner 
Published: June 2018

ZusammenfassungDie kreative Leistung des Nuklearmediziners wird am schriftlichen Befundbericht, die Qualität der Mitteilung aber nicht ausschließlich an der Treffsicherheit der medizinischen Aussage gemessen. Ein und derselbe Befund kann auf verschiedene Weise formuliert werden. Zahlreiche habituelle und akzidentelle Faktoren nehmen Einfluss darauf, was ausgesprochen und was nicht ausgesprochen wird bzw. was wie gewertet wird und was unbewertet bleibt. Der Leser hat ein feines Gespür für derartige Varianten. Selbst Nuancen der Formulierung können die Wertschätzung für den Bericht und die Reaktion des Empfängers auf das Ergebnis der Untersuchung beeinflussen. Je weniger sicher eine Diagnose ist und je weniger vorhersehbar ihre möglichen Konsequenzen sind, desto mehr Abstufungen und Umschreibungen sind im Bericht zu erwarten. Die Entscheidung über Art und Umfang des schriftlichen Befundberichts fällt nicht erst im Moment des Diktats, sondern wird durch Kenntnisse der Vorgeschichte und Symptomatik, den persönlichen Kontakt mit dem Patienten sowie durch eine Reihe von Umständen bei der Betrachtung der Bilder gebahnt. Die Nuklearmediziner setzen Beobachtung und Fachwissen in intra- und interindividuell unterschiedlicher Art und Weise in ihre diagnostische Botschaft um. Die Intuition beim Informationstransfer in der nuklearmedizinischen Diagnostik erklärt nicht nur die Unterschiede in Umfang und Tiefe von Diagnose und Differenzialdiagnose, sondern auch die Variationsbreite diagnostischer und therapeutischer Empfehlungen.
Sequence therapy in metastatic pancreatic cancer
Authors: Waidmann Oliver , Pelzer Uwe , Boeck Stefan , Waldschmidt Dirk-Thomas 
Published: June 2018

AbstractPancreatic cancer is one of the most lethal cancer diseases. For years, gemcitabine has been the standard of care and the only therapeutic option in patients with metastatic pancreatic cancer. Within the last years, new combination therapies have been established for first-line treatment, which significantly improve overall survival in comparison to gemcitabine monotherapy. Furthermore, new second-line therapies have been identified, which significantly improve overall survival. The current manuscript summarizes briefly standard of care first- and second-line chemotherapies and discusses possible treatment sequences.
Das Plattenepithelkarzinom des Naseneingangs – Eine Literaturübersicht
Authors: Koopmann Mario , Rudack Claudia , Weiss Daniel , Stenner Markus 
Published: June 2018

Zusammenfassung
Hintergrund Das Plattenepithelkarzinom des Naseneingangs (Vestibulum nasi) ist eine sehr seltene Tumorentität. In der Konsequenz herrscht bezüglich der
Ätiologie, des Stagings und der notwendigen Therapie dieser Tumoren nach wie vor Uneinigkeit. Insbesondere die Mitbehandlung regionaler Lymphknotenstationen ist
Gegenstand wissenschaftlicher Diskussionen.
Methode Alle via Pubmed gefundenen Artikel zum Thema wurden hinsichtlich folgender Themenschwerpunkte untersucht: Lymphatische Versorgung, Metastasierung,
Inzidenz, Prognose, Risikofaktoren (Leder, Nickel, Nikotin, Humane Papillomaviren), Tumorklassifikationssystem (UICC-, AJCC-, Wang-Klassifikation), Therapie des
Primärtumors, Therapie regionaler Lymphknoten und Immunhistochemie.
Ergebnisse Im vorliegenden Übersichtsartikel wurden 55 Veröffentlichungen ausgewertet. Die Ergebnisse hinsichtlich der untersuchten Aspekte sind in sich
inhomogen.
Schlussfolgerungen Als Klassifikationssystem wird die Wang-Klassifikation empfohlen. Für die Behandlung kleinerer Tumoren (T1-T2-Wang) kommen operative
Resektionen oder Bestrahlungen in Betracht. Größere Tumoren (T3-Wang) sollten reseziert und einer adjuvanten Bestrahlung zugeführt werden. Im Falle einer
cT1-cT2cN0-Situation kann – eine dezidierte bildgebende Diagnostik vorausgesetzt – auf eine elektive Therapie der regionalen Lymphknoten verzichtet werden.
Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature
Authors: Fragkos Konstantinos , Barragry John , Fernando Charisma , Novelli Marco , Begent Joanna , Zárate-Lopez Natalia 
Published: June 2018

AbstractEosinophilic colitis is a rare clinical condition that belongs to the group of eosinophilic gastrointestinal disorders. Its occurrence can be primary or secondary to infection, medications, or autoimmune/hematological conditions. We present a case of a young female adult with severe chronic fatigue syndrome, widespread chronic pain, including functional abdominal pain, who developed severe eosinophilic colitis following successive treatments with gabapentin and pregabalin. On both occasions, symptoms manifested as abdominal pain, diarrhea, and eosinophilia and improved upon discontinuation of the medications. Magnetic resonance imaging of the small bowel demonstrated an ascending colon colitis, and endoscopic investigations confirmed florid colitis mainly in the ascending colon with biopsies demonstrating a dense eosinophilic infiltrate with micro-abscesses. Serum eosinophil counts correlated well with the timing of the agents’ administration. There was no other organ involvement. Symptoms improved upon discontinuation of the drugs and steroid administration. Eosinophilic colitis is an exceptionally rare entity and its mechanism of action is still unclear. Suspicion of eosinophilic colitis should be raised if a patient presents with abdominal pain, diarrhea, and peripheral eosinophilia following treatment with pregabalin or gabapentin.
Psychosomatik in der Gastroenterologie – Stellungnahme der Arbeitsgemeinschaft Psychosomatik in der Gastroenterologie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
Authors: Auer Peter , Enck Paul , Häuser Winfried , Stengel Andreas , Storr Martin , Langhorst Jost ,   AG Psychosomatik in der Gastroenterologie der DGVS
Published: June 2018

ZusammenfassungDie Arbeitsgemeinschaft Psychosomatik in der Gastroenterologie der DGVS hat das Anliegen, das Profil psychosomatischer Anteile in Diagnostik, Differenzialdiagnostik und Therapie gastroenterologischer Krankheitsbilder zu schärfen, vermehrt psychosomatische Aspekte in Weiterbildungsordnung und Leitlinienarbeit zu etablieren, die Zusammenarbeit mit psychosomatischen Fachgesellschaften zu vertiefen und nicht zuletzt die Arbeitszufriedenheit und psychische Gesundheit der Gastroenterologinnen und Gastroenterologen in Deutschland zu stärken.
The Effect of Metformin Therapy for Preventing Gestational Diabetes
Mellitus in Women with Polycystic Ovary Syndrome: A
Meta-Analysis
Authors: Zhao Jing , Liu Xiaoyan , Zhang Wenhua 
Published: June 2018

Abstract
Objective This study was to analyze the efficacy of metformin
intervention in preventing gestational diabetes mellitus (GDM).
Methods A systematic review and meta-analysis of clinical trials or
observational studies of metformin intervention in preventing symptoms of
GDM during pregnancy were performed. Medline, Embase, and Cochrane Library
were searched through to now. The main evaluated primary outcomes were
incident of GDM, miscarriage, preterm delivery, and neonatal mortality. The
evaluated secondary outcomes were mean difference of gestational age at
birth and birth weight between metformin group and control group.
Results We included 6 studies including 3 randomized clinical trials
(RCTs), 2 observational studies, and 1 non-RCT in our meta-analysis. A total
of 643 patients were enrolled for a follow-up study with continued metformin
therapy (n=341) or not (n=302) during pregnancy. Metformin
therapy reduced the proportion of patients developing GDM (log Odds Ratio:
-1.27; 95%CI: -2.24 to -0.30) but had no significant effect on
reducing the proportion of abortion, preterm delivery, and neonatal death in
pregnant women with polycystic ovary syndrome (PCOS). Also, it did not cause
a significant difference in gestational age at birth and birth weight in
metformin group versus control/placebo group.
Conclusions Metformin was associated with less frequent GDM
development than control diets, suggesting that it is the appropriate
intervention to be prescribed to prevent GDM in patients with PCOS.
Antientzündliches Essen
Authors: Martin Hans-Helmut , Bansner Julia , Schäfer Sylva 
Published: June 2018

SummaryViele Erkrankungen gehen mit chronischen Entzündungsreaktionen einher, z. B. Atherosklerose, viszerale Adipositas, Dislipoproteinämie oder Gicht. Die sog. Low-Grade-Inflammation entsteht u. a. als Reaktion auf Umweltbedingungen und ungesunden Lebensstil. Auch Ernährungsfaktoren spielen eine Rolle, die eine anhaltende Hyperglykämie begünstigen können und in der Folge negative Auswirkungen auf den Stoffwechsel haben. Der Grundlagenbeitrag behandelt entzündungsfördernde Ernährungsfehler und gibt Empfehlungen, welche Nahrungsmittel antioxidatives Potenzial aufweisen.
The Role of Different Molecular Markers in Papillary Thyroid Cancer Patients with Acromegaly
Authors: Keskin Fatma Ela , Ozkaya Hande Mefkure , Ferahman Sina , Haliloglu Ozlem , Karatas Adem , Aksoy Figen , Kadioglu Pinar 
Published: June 2018

Abstract
Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules.
Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues, thyroid samples of 13 patients from 19 with acromegaly related PTC (APTC), 20 normal PTC and 20 patients with multinodulary goiter (MNG) were histopathologically evaluated. Protein expressions were determined via immunohistochemical staining in ex-vivo tumor samples and benign nodules.
Results The incidence of PTC in acromegaly patients were 6% (n=19). Among patients with PTC, APTC and MNG, all the immunohistochemical protein expressions we have studied were higher in papillary thyroid cancer groups (p<0.01, for all). Between PTC group without acromegaly and APTC, galectin 3 and IGF1 expression was significantly higher in acromegalic patients (p<0.01 for all) while RAS was predominantly higher in PTC patients without acromegaly (p<0.01).
Conclusion BRAF expression was not higher in PTC with acromegaly patients compared to PTC patients without acromegaly. Galectine 3 and IGF1 were expressed more intensively in APTC. These positive protein expressions may have more influence on determining malign nodules among acromegaly patients.
Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway
Authors: Yang Huihui , Kan Quan e , Su Yong , Man Hua 
Published: June 2018

AbstractIt’s known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease. ROC curve analysis showed that serum level of CASC2 could be used to accurately predict diabetic nephropathy. Diabetes mellitus has many complications. This study also included a series of complications of diabetes, such as diabetic retinopathy, diabetic ketoacidosis, diabetic foot infections and diabetic cardiopathy, while serum level of CASC2 was specifically reduced in diabetic nephropathy. CASC2 expression level decreased, while JNK1 phosphorylation level increased in mouse podocyte cells treated with high glucose. CASC2 overexpression inhibited apoptosis of podocyte cells and reduced phosphorylation level of JNK1. We conclude that long non-coding RNA CASC2 may improve diabetic nephropathy by inhibiting JNK pathway.
Recent Advances in NMR: Aggregation, Solvation, and Dynamics of Selected Organolithium Compounds
Authors: Oulyadi Hassan 
Published: June 2018

Nuclear magnetic resonance (NMR) spectroscopy is the most widely used analytical technique to study the structure and dynamics of organolithium compounds, which are the most popular reagents in organic synthesis due to their great diversity and high reactivity. The main strength of this method is that it allows direct analysis in solution of the aggregation, dynamic, and solvation state of reactive intermediates. In this review, we present the NMR tools (nD) involving the 6Li isotope and DOSY experiments with internal references and illustrate their contribution in the structural and dynamic characterization of organolithium compounds in solution through some selected example.1	Introduction2	Advantages of the 6Li isotope3	NMR Experiments Involving the 6Li Isotope4	Diffusion Ordered NMR Experiments5	Application of NMR to the Structural Characterization of Organolithium Species6	Conclusion
Use of the Animal Trauma Triage Score, RibScore, Modified RibScore and Other Clinical Factors for Prognostication in Canine Rib Fractures
Authors: Bacek Lenore , Kim Kyoung , Miller George , Gaillard Philippe , Kuo Kendon , McCarthy Daniel 
Published: June 2018

Objectives To characterize the clinical features among dogs sustaining rib fractures and to determine if age, type and severity of injury, entry blood lactate, trauma score and rib fracture score were associated with outcome.
Methods A retrospective study was performed to include dogs that were presented with rib fractures. Risk factors evaluation included breed, age, body weight, diagnosis, presence of a flail chest, bandage use, puncture wound presence, rib fracture number, location of the fracture along the thoracic wall, hospital stay length, body weight, other fractures, pleural effusion, pulmonary contusions, pneumothorax and occurrence of an anaesthetic event. A retrospective calculation of an animal trauma triage (ATT) score, RibScore and Modified RibScore was assigned.
Results Forty-one medical records were collected. Motor vehicular trauma represented 56% of the rib fracture aetiology, 41% of patients sustained dog bites and one case was of an unknown aetiology. Significant correlations with risk factors were found only with the ATT score. All patients that died had an ATT score ≥ 5. The ATT score correlated positively with mortality (p < 0.05) with an ATT score ≥ 7 was 88% sensitive and 81% specific for predicting mortality. A 1-point increase in ATT score corresponded to 2.1 times decreased likelihood of survival. Mean hospital stay was 3 days longer for dog bite cases.
Clinical Significance There was no increased mortality rate in canine patients that presented with the suspected risk factors. The only risk factor that predicted mortality was the ATT score.
A Rare Syndrome and a Rare Association: Dandy–Walker Malformation and Cockayne Syndrome in a Child
Authors: Işıkay Sedat , Bilgin Burak , Karaer Kadri , Şirikçi Akif 
Published: June 2018

AbstractCockayne syndrome is a rare autosomal recessive, neurodegenerative disorder characterized by a broad spectrum of clinical symptoms. Herein, we will describe a patient diagnosed with Cockayne syndrome by genetic testing who was also determined to be having Dandy–Walker malformation in brain imaging. In this article, we aimed to highlight the general characteristic findings of Cockayne syndrome and to report the togetherness of these two rare entities.
Functional Reconstruction with Latissimus Dorsi Flap following Resection of an Extensive Basal Cell Carcinoma in the Shoulder Region: A Case Report
Authors: Paprottka Felix , Klimas Dalius , Hebebrand Detlev 
Published: June 2018

AbstractLarge and ulcerating skin tumors have become a rarity in the modern Western world. However, these conditions can cause serious life-threatening complications. The case of a 60-year-old male Caucasian patient is reported, who had suffered from an extensive basal cell carcinoma in the right shoulder region for several years. The patient kept the lesion secret from his friends and family and delayed presentation to health care services. After an episode of tumor-related heavy bleeding, the patient was referred to our clinic and received a radical surgical tumor resection—followed by defect coverage with a latissimus dorsi myocutaneous flap. An alternative treatment option that could be offered to the patient would have been a mutilating surgical procedure with an arm amputation. By using this plastic reconstructive surgical technique, the main function of the shoulder joint was conserved. The presented case demonstrates options for defect coverage of problematic wounds in anatomically complex body regions—like the shoulder—by using a functional reconstruction using myocutaneous flaps.
Recurrent Pituicytoma in a Pediatric Patient: A Case Report
Authors: Maldonado-Morán Miguel , Ospina Jeisson , Vega Juan , Restrepo Claudia , Rico Daniela , Zubieta Camilo , Penagos Pedro 
Published: June 2018

AbstractPituicytoma is a rare tumor that arises from the glial cells of the neurohypophysis. For a long time, it was believed that pituicytomas only appeared in adults. Currently, at least three cases of this entity occurring in children have been reported in the literature. The aim of the present report is to describe the case of a 5-year-old girl who presented to the emergency department with visual disturbances, and the diagnosis was a recurrent pituicytoma. Therefore, the clinical presentation, the radiological features of the tumor, and the corresponding surgical management are described. Additionally, a brief review of the management of this unusual entity was performed.
Diagnostik und Therapie von Clostridium-difficile-Infektionen auf deutschen Intensivstationen – eine Umfrage unter Intensivmedizinern
Authors: Bruensing Jan , Buendgens Lukas , Jochum Christoph , Herbers Ulf , Canbay Ali , Braun Georg , Trautwein Christian , Huber Wolfgang , Koch Alexander , Tacke Frank 
Published: June 2018

Zusammenfassung
Einleitung Die Clostridium-difficile-assoziierte Kolitis ist eine häufige nosokomiale Durchfallerkrankung auf Intensivstationen mit relevantem Einfluss auf die Prognose kritisch kranker Patienten. In der Intensivmedizin gibt es derzeit kaum kontrollierte Studien zum rationalen Einsatz der verfügbaren Therapieoptionen oder zur Adhärenz gegenüber Leitlinienempfehlungen.
Methode Im Auftrag der AG Gastroenterologische Intensivmedizin der DGVS haben wir eine Online-basierte Befragung von Führungskräften deutscher Intensivstationen durchgeführt, um das aktuelle Management der Clostridium-difficile-Infektion auf Intensivstationen zu erfassen.
Ergebnis Die Erhebung erzielte einen Rücklauf von 24,2 % (85/351), überwiegend von (leitenden) Oberärzten/innen aus Krankenhäusern verschiedener Versorgungsstufen. Während für die Diagnostik größtenteils (79,3 %) Standards entsprechend der Leitlinien existierten (Toxinnachweis im Stuhl, ggfs. GDH-Screening und Endoskopie), gab es unterschiedliche therapeutische Strategien. Als Erstlinienbehandlung der Clostridium-difficile-Infektion auf der Intensivstation nannten 48,3 % orales Vancomycin, 34,5 % orales Metronidazol; der Therapieerfolg der Erstlinientherapie wurde mit 67 % für primäres Ansprechen, 15 % für persistierende Kolitis, 5 % für Sepsis oder Megakolon, 10 % für Rezidiv und 3 % für Tod abgeschätzt. Krankenhäuser der Grund-/Spezial- und Maximalversorgung setzten häufiger Metronidazol ein als Universitätskliniken. Die Standardbehandlung des Rezidivs bestand überwiegend aus Vancomycin oral (40 % allein, 29,1 % plus Metronidazol), seltener aus Fidaxomicin (25,5 %). Fidaxomicin wurde von 79 % der Befragten bereits mindestens einmal auf der Intensivstation eingesetzt, meist bei schwerem Krankheitsverlauf oder Rezidiv(risiko). Der fäkale Mikrobiomtransfer („Stuhltransplantation“) wurde von 11 % der Befragten bereits auf der Intensivstation in Einzelfällen eingesetzt.
Diskussion Die Umfrage unter Führungskräften deutscher Intensivstationen zeigt damit insgesamt eine hohe Sensibilisierung für die Clostridium-difficile-assoziierte Kolitis, allerdings auch deutliche Unterschiede in den lokalen Behandlungsstandards, insbesondere in der Erstlinientherapie.
The tapestry of Chinese capital in the Global South
Authors: Hung Ho-fung 
Published: June 2018

AbstractThough China’s capital export is not as big as many journalistic and think tank reports portray, it is definitely a rising force in shaping the context of development in many developing countries. Excluding capital flight to financial centers, most Chinese outward investment to developing regions is in the extractive, infrastructure, and trade sectors. Chinese governmental foreign aid, mostly in the form of grants and loans, has been rising in the developing world too. The form and size of China’s inroad into the Global South vary from country to country, depending on individual countries’ geopolitical and geoeconomic relation with China, as well as the countries’ natural resources endowment. The existing literature on China in the Global South focuses mostly on Africa. This paper accompanies an article collection that expands our knowledge on China’s variegated impact by looking into Argentina, Pakistan, the Philippines, and Central Asia. It also looks into how China is reshaping the structure of global politics at large.
Institutional dimensions of the future of philosophy of religion
Authors: Whitney Lawrence A. 
Published: June 2018

AbstractIf there is going to be a future for the philosophy of religion, it is going to have to emerge out of and speak into a set of contested disciplinary, institutional, and ideological spaces as their boundaries are in the process of being renegotiated. In the first instance, philosophy of religion has traditionally been located somewhere among the disciplines of philosophy, theology, and religion, but each of these fields is undergoing transformation to which philosophy of religion must respond. At the same time, accreditation standards are requiring humanities disciplines to shift their pedagogical practices even as the commodification of higher education culturally and institutionally calls into question the value of humanistic formation. This paper outlines the points of tension that put pressure on philosophy of religion and suggests ways in which the subdiscipline might understand and locate itself at the heart of liberal and general education in the future.