bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial and antifungal two phenolic sesquiterpenes from Dysoxylum densiflorum
Authors: Dharmayani Ni Komang T. , Yoshimura Tsuyoshi , Hermawati Elvira , Juliawaty Lia D. , Syah Yana M. 
Published: October 2019

Abstract
A new phenolic sesquiterpene, dysoxyphenol (1), and the known sesquiterpene, 7R,10S-2-hydroxycalamenene (2), were isolated from the acetone extract of Dysoxylum densiflorum seeds. The structures of these compounds were determined based on physical, Nuclear Magnetic Resonance, and mass spectral data. Both compounds were evaluated for their antibacterial and antifungal properties against seven pathogenic bacteria and two wood-rotting fungi, respectively. The results showed that both compounds have significant antibacterial properties only against Bacillus subtilis (Minimum Inhibitory Concentration 28 μM), while in the antifungal evaluation compound 1 was found to be more active than compound 2. Therefore, compound 1 has promising antifungal properties that can be developed further for finding new antifungal agents.
Inference of Selection from Genetic Time Series Using Various Parametric Approximations to the Wright-Fisher Model
Authors: Paris Cyriel , Servin Bertrand , Boitard Simon 
Published: October 2019

Abstract
Detecting genomic regions under selection is an important objective of population genetics. Typical analyses for this goal are based on exploiting genetic diversity patterns in present time data but rapid advances in DNA sequencing have increased the availability of time series genomic data. A common approach to analyze such data is to model the temporal evolution of an allele frequency as a Markov chain. Based on this principle, several methods have been proposed to infer selection intensity. One of their differences lies in how they model the transition probabilities of the Markov chain. Using the Wright-Fisher model is a natural choice but its computational cost is prohibitive for large population sizes so approximations to this model based on parametric distributions have been proposed. Here, we compared the performance of some of these approximations with respect to their power to detect selection and their estimation of the selection coefficient. We developped a new generic Hidden Markov Model likelihood calculator and applied it on genetic time series simulated under various evolutionary scenarios. The Beta with spikes approximation, which combines discrete fixation probabilities with a continuous Beta distribution, was found to perform consistently better than the others. This distribution provides an almost perfect fit to the Wright-Fisher model in terms of selection inference, for a computational cost that does not increase with population size. We further evaluated this model for population sizes not accessible to the Wright-Fisher model and illustrated its performance on a dataset of two divergently selected chicken populations.
Felipe Gómez Gutiérrez y María del Carmen Saldarriaga (Eds.). <em>Evelio Rosero y los ciclos de la creación literaria</em>. Bogotá: Pontificia Universidad Javeriana, Opera Eximia, 2017, 272 páginas
Authors: García Argüelles Elsa Leticia 
Published: October 2019

Felipe Gómez Gutiérrez y María del Carmen Saldarriaga (Eds.). Evelio Rosero y los ciclos de la creación literaria . Bogotá: Pontificia Universidad Javeriana, Opera Eximia, 2017, 272 páginas
Importância do conhecimento sobre saúde bucal dos cuidadores de pacientes com necessidades especiais
Authors: Pereira Claudio Maranhão , Da Rocha Gislaine Ribeiro De Oliveira Margon , Castro César Emmanuel Borges , De Sá Paula Frassineti Guimarães 
Published: October 2019

Objetivos: Analisar o conhecimento de mães e/ou cuidadores de PNE em relação à higienização e aos cuidados relacionados a saúde oral de seu(s) filho(s) e determinar as principais dificuldades apontadas pelos entrevistados em relação à sua manutenção.Métodos: Os participantes foram avaliados por meio de um questionário constituído por 10 perguntas, de múltipla escolha, entregue aos cuidadores e/ou mães de PNEs, matriculadas no Centro de Ensino Especial 01, em Brasília-DF.Resultados: Apesar dos resultados positivos em relação ao conhecimento de mães e/ou cuidadores em relação às rotinas de higienização e cuidados com a saúde oral do PNE, o nosso estudo aponta que ainda existem algumas lacunas a serem consideradas, no âmbito da prevenção e da promoção da saúde bucal. Na amostra analisada, houve aqueles que não levaram o seu(ua) filho(a) a nenhuma consulta odontológica no ano anterior e aqueles que nunca participaram de nenhuma atividade educativa ou treino para auxiliar o PNE com a higienização oral. Conclusão: A demanda por atendimento odontológico é crescente no grupo de PNE, cabendo aqui ressaltar que a saúde bucal permeia um dos direitos fundamentais garantidos pela nossa constituição. Assim, a real implantação do Plano Nacional dos Direitos da Pessoas com Deficiência na rede de assistência pode contribuir significativamente para que equipes de Atenção Primária e os Centros de Especialidade Odontológicas possam atuar com os cuidadores, além de atender adequadamente a PNE.
Relación entre la estructura financiera y rentabilidad de las empresas que cotizan en la Bolsa de Valores de Lima, 2014
Authors: Díaz Correa Edith Damaris , Contreras Salluca Noelia Patricia , Vallejos Angulo Christian Daniel , Álvarez Manrique Víctor Daniel 
Published: October 2019

El objetivo del presente trabajo de investigación es determinar la relación entre la estruc-tura financiera y la rentabilidad de las empresas que cotizan en la Bolsa de Valores de Lima (BVL), durante el periodo, 2014. El tipo de estudio utilizado es correlacional con un diseño no experimental, transversal retrospectivo. La población está constituida por un total de 151 empresas. Los datos fueron recolectados de los estados financieros comparados de la memoria anual de estados financieros declarados. El análisis de los datos tuvo los siguientes resultados: 1) el 66,2% de las empresas presentan una estructura financiera conservadora y el 33,8%, una estructura financiera agresiva, 2) la rentabilidad financiera y la rentabilidad económica presenta un nivel medio en ambos casos con un 49,0%, 3) mediante la prueba de X2 se obtuvo un coeficiente de 9.228 y p-valor 0.01, aceptándose la hipótesis alternativa: existe relación entre la estructura fianciera agresiva y la renta-bilidad financiera; así mismo se obtuvo un coeficiente de 1,063 con un p-valor de 0.588, aceptándose la hipótesis nula: no existe relación entre la estructura financiera y la ren-tabilidad económica. Se concluye que la mayoría de las empresa incluidas en el estudio presenta una estructura financiera conservadora. Además en cuanto a las empresa que asumen una estructura financiera agresiva experimentan mayor índices de rentabilidad financiera, no así con la rentabilidad económica.
Comparison of the safety and efficacy of the new method of en-bloc and conventional monopolar transurethral resection in the management of primary non-muscle-invasive bladder cancer
Authors: Krasny S. A. , Masanskiy I. L. 
Published: October 2019

Objective: to comparе the safety and efficacy of the new method of en-bloc transurethral resection (TUR) and conventional TUR in management of primary non-muscle-invasive bladder cancer, and investigate long-term effects on tumour recurrence and progression.Materials and methods. A total of 914 patients with primary non-muscle-invasive bladder cancer were treated using TUR of bladder at the Minsk City Clinical Oncologic Dispensary in 2005 to 2016. For final analysis the data was underwent many-stage random sampling. Randomization was stratified according to sex and age, category T, tumour grade, EORTC risk groups. In total, 273 patients were selected: 136 in the new method of en-bloc TUR group (a study group) and 137 in the conventional TUR group (a control group). The new method of en-bloc TUR is based on using impulses of high-frequency current applied to the active electrode of the resectoscope. The impulse sequence and individual impulse duration within the interval from 0.1 to 1 second are controlled in the course of the operation. Five-year follow-up data of operative management were analyzed.Results. In event of the new method of en-bloc TUR there were no perioperative complications and no cases of conversion to conventional TUR. Postoperative complications were less frequently observed in the new method group compared with conventional TUR group. There were significant differences with major priority to the new method of en-bloc TUR in median time to recurrence (р = 0.032) and progression (р = 0.001), 5-year survival to recurrence (р = 0.0001) and progression (р = 0.001), 5-year cancer-specific survival (р = 0.033) and overall survival (р = 0.045) of patients.Conclusion. The new method of en-bloc TUR of non-muscle-invasive bladder cancer was more effective than conventional TUR in reducing rates of intraand postoperative complications, and at the same time was applicable in all clinical cases, regardless of the tumor location in the bladder lumen, its size, vascularization, and growth pattern. The new method of en-bloc TUR also significantly improved the long-term cancer treatment results in patients with primary non-muscle-invasive bladder cancer.
Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm
Authors: Potapov A. L. , Kaprin A. D. , Ivanov S. A. , Boiarkina A. V. , Novikov N. Yu. , Gevorkyan R. R. , Kostyuk I. P. 
Published: October 2019

Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of μ1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm.
A cross-sectional study to evaluate the effect of subjective sleep quality on autonomic functions in different age groups of adults
Authors: Jasrotia Rajani Bala , Kanchan Arvind , John Nitin Ashok , Verma Manish Kumar , Gangwar Vibha 
Published: October 2019

Background: Poor sleep quality adversely affects the person’s homeostasis via combination of impairments to multiple physiological-mechanisms. Autonomic functions are important for different aspects of health and disease. Objective of study was to analyze the impact of subjective sleep quality on autonomic functions in different age groups of adults.Methods: A total of 375 apparently healthy adults from community were randomly selected for this cross-sectional observational study. They were divided into three groups based on the age distributions: Group 1: 18-30 years (n = 146); Group 2: 31-45 years (n = 112); and Group 3: 46-60 years (n = 117). Following assessments were done in all the participants in three groups: Anthropometric measurements, Pittsburgh Sleep-quality Index (PSQI), Electrocardiography (ECG), Autonomic functions based on frequency domain heart rate variability (HRV). Two-way analysis of variance followed by post hoc analysis was done for intergroup comparisons of all assessment characteristics. Spearman’s correlation was done to find the correlation coefficients between PSQI scoring and all other parameters mentioned above.Results: BMI, GPSQIS, SSQS, SDS and SMS were observed more in group2 and 3 as compared to group1, whereas SD and SE were more in group1 as compared to group 2 and 3. HF, Total Power and RR were more in group 1 as compared to group 3, whereas VLF and HR were less in group 1 as compared to group 3. LF/HF ratio and HR were more in group 3 as compared to group 2, whereas HF was more in group 2 as compared to group 3. There was statistically significant negative correlation between GPSQI and Total power, SMS and HF, SIT and HF, SD and LF/HF ratio, whereas statistically significant positive correlation between SMS and LF, SMS and LF/HF ratio, SIT and LF, SIT and LF/HF ratio, SD and total power as well as SE and total power.Conclusions: Ageing in adults affects the sleep-quality, reduces the sleep duration and decreases the sleep efficiency; these contribute to autonomic dysfunction as increased sympathetic activity and decreased parasympathetic activity in older adults as compared to younger adults.
Influence of immobilized form of sodium hypochlorite on the functional condition of internal organs, systemic inflammatory response, oxidative stress, antioxidant protection and dysfunction of endothelium in experimental infected pancreonecrosis
Authors: Sukhovatih Boris Semyonovich , Elenskaya Elena Alexandrovna , Blinkov Yuriy Yurievich , Alimenko Oleg Vladimirovich 
Published: October 2019

Importance of the topic. Mortality in infected pancreonecrosis varies from 40% to 60%.
Purpose is to study the influence of immobilized form of sodium hypochlorite on the functional condition of internal organs, systemic inflammatory response, oxidative stress, antioxidant protection and endothelium dysfunction in experimental infected pancreonecrosis.
Materials and methods. Experimental studies were conducted on 60 male rats of Wistar line, which were divided into 3 similar groups with 20 animals in each group: control, comparison and experimental ones. Animals did not receive any treatment in control group, Levomekol ointment was applied to the infected area rats from comparison group, and the immobilized form of sodium hypochlorite was used in experimental group. The modeling of the infected pancreonecrosis was conducted by destruction of the pancreas by the liquid nitrogen and contamination with the microbial suspension of the Staphylococcus aureus. Indicators of the pancreas function, renal function, liver function, vessels’ endothelium, systemic inflammatory response, oxidative stress, antioxidant protection were studied by laboratory methods on the 3rd, 5th, 7th and 10th days of the experiment.
Results and their discussion. Immobilized form of sodium hypochlorite surpassed Levomekol ointment in its positive influence on oxidative stress in 3.8 times, on antioxidant activity – in 1.6 times, on endothelium dysfunction – in 1.5 times, pancreas dysfunction – in 1.3 times, renal dysfunction – in 1.7 times, liver dysfunction – in 1.32 times, in severity of inflammatory response – in 1.5 times by the end of the experiment (p<0.05).
Conclusion. Application of the immobilized form of sodium hypochlorite in infected experimental pancreonecrosis is effective and justified by pathogenesis.
Electrical function of the abdominal muscles after combined plastic of extensive median hernias in the context of connective tissue dysplasia
Authors: Railianu Radu 
Published: October 2019

Relevance. Improving the electrical function of abdominal muscles in patients with extensive median hernias of the anterior abdominal wall can be facilitated by optimizing the choice of methods for combined hernioplasty, taking into account the clinical severity of connective tissue dysplasia among the hernia carriers.
Objective. Study the electrical function of abdominal muscles after the methods of combined hernioplasty of extensive median hernias, taking into account the severity of connective tissue dysplasia among the hernia carriers.
Results. The average numbers of electromyogram frequencies of the abdominal muscles of patients with extensive median hernias from the group without clinical signs of connective tissue dysplasia were almost the same after all the applied methods of combined hernioplasty. The predominance of the rectus muscles electric function over the lateral abdominal muscles among the patients of this group was 33,5 %.
Electrofunctional rehabilitation of the abdominal muscles of patients in the second group of examinations depended on the method of combined hernioplasty and changed in the event of an increase or decrease in the severity of connective tissue dysplasia. The recovery of electroactivity of abdominal muscles in the postoperative period in patients from the second group was more significant with an increase in the number of abdominal muscles applied to aponeuroses and vagina of relaxing sections, which contributed to an increase in mobility and contractility of the musculoaponeurotic layers of the anterior abdominal wall.
Conclusions. Thus, with an increase in the severity of connective tissue dysplasia in patients with extensive median abdominal hernias, the method of combined hernioplasty with the most pronounced relaxing effect in relation to the anterior abdominal wall promoted optimal rehabilitation of abdominal muscles.
COMPLIANCE ASSESSMENT OF AQUACULTURE DEVELOPMENT TRENDS IN THE RUSSIAN FEDERATION TO UNIVERSAL TRENDS
Authors: A. Gurkovskaya Elena , A. Larionova Anna , A. Zaitseva Natalia , A. Purtskhvanidze Violeta , R. Maksyutov Ruslan , V. Sharoiko Fedor , V. Ivanov Mikhail 
Published: October 2019

Purpose of the study: The relevance of the research topic is due to the fact that the development of aquaculture is one of the key tools to ensure the necessary level of food security both in Russia in particular and on a global scale in general. The purpose of the article is to assess the development of aquaculture in Russia, in the context of global trends.
Methodology: To analyze the existing problem, theoretical and empirical methods, data aggregation methods, expert evaluation, classification and structuring of information, reference and statistical data, and a comparison method were used.
Results: The paper summarized the scientific and theoretical foundations of the definition’s essence of the “aquaculture” concept, as a result of which this concept was clarified, a classification of the main sub-complexes of aquaculture was given. The main vectors for the implementation of a systemic approach to the development of aquaculture, which have their relevance both nationally and globally, are highlighted. The article analyzes the current state and development trends of world aquaculture and fisheries, as well as the development of domestic aquaculture. The authors share the position of most scientists that in the medium term, aquaculture will occupy a dominant position compared to fishing, not only for environmental but also for economic reasons. According to the results of the study, it was concluded that in Russia, despite the presence of huge resource potential for the development of aquaculture, the main indicators for the functioning of this industry are significantly lagging behind global trends.
Applications of this study: Measures aimed at the formation of the growing trends of aquaculture development in Russia were proposed.
Novelty/Originality of this study: It can be noted that the implementation of the presented set of measures will contribute to the formation of growing trends in the development of aquaculture in Russia, which will correspond to the main global trends in this field.
The Methodological Convergences between Symbolic Interactionism and Constructivist Grounded Theory
Authors: Salvini Andrea 
Published: October 2019

This article explores the connection between Constructivist Grounded Theory (CGT) and Symbolic Interactionism (SI) in the light of the methodological position presented in Herbert Blumer’s Symbolic Interactionism: Perspective and Method. The examination of this connection will take place in three steps: firstly, I will offer some preliminary considerations with regard to ‘variant forms’ in Grounded Theory (GT) as well as cite the present debates about the differences and similarities between different approaches within it; then, I will describe the essential characteristics of the ‘methodological position’ of SI and build some lines of continuity between these elements and the main tenets of constructionist GT; finally, I will present ten conceptual expressions and methodological practices in which it is possible to verify the methodological convergence between the two perspectives. This analysis makes it possible to consider the Constructivist Grounded Theory as a set of coherent principles, methods, and research practices from the point of view of a scholar inspired by the SI’s perspective. However, the peculiar reference to the methodological position of SI does not exhaust the set of possible epistemological and methodological sources, from which the perspective of GT derives. Instead, it represents a controversial point, with regard to which the debate still appears to be particularly heated.
Ege ve Akdeniz Bölgesinde Pamuk Çökerten Hastalığının Kontrolünde Tohuma Uygulanan Bazı Fungisitlerin Etkililiklerinin Belirlenmesi
Authors: TOSUN Necip , YILMAZ Önder 
Published: October 2019

Amaç: Bu
araştırmanın amacı 2008-2009 yılları arasında pamuk üretiminin yoğun yapıldığı
Akdeniz (Hatay) ve Ege (Söke/Aydın) Bölgelerindeki fide kök çürüklüğü
(çökerten) hastalık etmenlerinin yaygınlık oranlarını saptamak ve bu hastalığa
karşı denenen 4 farklı kimyasal preparatın hastalık üzerindeki etki oranlarını
belirlemektir.

Materyal ve Metot: Araştırmanın materyalini
Bayer firmasının Hatay ve Söke/Aydın’da saptadığı Rhizoctonia,
Alternaria, Fusarium ile bulaşık
fidelerin bulunduğu alanlar, Carboxin+thiram (Vitavax 200 FF),
Azoxystrobin+Metalaxyl – M+Fludioxonil FS (Dynasty CST 125 FS) 75+37,5+12,5
g/l, Metalaxyl – M+Fludioxonil (Maxim XL
035 FS) aktif maddeli ilaçlar ve Fiber Max
çeşitlerine ait pamuk tohumları oluşturmaktadır. Çalışma tesadüf blokları
deneme desenine göre dört tekerrürlü olarak gerçekleştirilmiştir.

Bulgular:
Çalışma bulgularına baktığımızda tarla
denemelerinde fide kök çürüklüğü hastalığına karşı etkinlik açısından Hatay’da
en iyi sonuç Abbott’a göre % 84.37 ile
MAXIM XL FS 035 ile ilaçlanan tohumlardan oluşturulan parsellerde ve
Söke/Aydın’da en iyi sonuç Abbott’a göre % 61.02 ile VITAVAX 200 FF 600 ile
ilaçlanmış tohumlardan oluşturulan parsellerde olduğu saptanmıştır. Ayrıca en
fazla sağlıklı bitki çıkışı yine bu ilaçların kullanıldığı parsellerde
gözlemlenmiştir.

Sonuç: Bu çalışma ile denemede kullanılan MAXIM
XL FS 035 ve VITAVAX 200 FF 600 ile hastalıkla mücadele açısından ümitvar
sonuçlar elde edilmiştir.
THE RELATIONSHIP BETWEEN FAMILY HISTORY, CONSUMPTION OF FRUITS AND VEGETABLES, AND PHYSICAL ACTIVITY AND HYPERTENSION
Authors: Syamsi Farida 
Published: October 2019

Background: The prevalence of hypertension in 2018 in Indonesia in people aged ≥ 18 years was 34.11%, an increasing trend compared to 2013, when it was 25.80%. Malang Region increased the prevalence of hypertension from 7.32% in 2016 to 9% in 2017. Purpose: This study aims to analyse the relationship between hypertension and the variables of family history, consumption of fruit and vegetables, and physical activity in Integrated Guidance Post Wajak District, Malang Region. Methods: This study is an observational study with a cross-sectional design. It used 2018 secondary data from P2PTM section of Provincial Health Agency of East Java. The total sample was 250 respondents in Integrated Guidance Post, Wajak District, Malang Regency. The independent variables were family history, consumption of fruit and vegetables, and physical activity, while the dependent variable was hypertension. Data were analysed using a chi-square test. Results: A significant relationship was found between the independent variables family history (p = 0.01; PR = 2.01; 95% CI = 1.21 < PR <3.34), consumption of fruit and vegetables (p = 0.02; PR = 1.89; 95% CI = 1.13 < PR <3.14), and physical activity (p = 0.00; PR = 2.85; 95% CI = 1.70 < PR < 4.77) and the dependent variable of hypertension. Conclusion: There was a relationship between the independent variables of family history, lack of consumption of fruit and vegetables, and lack of physical activity and the dependent variable of hypertension.