bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectroscopy of NGC 4258 Globular Cluster Candidates: Membership Confirmation and Kinematics
Authors: González-Lópezlira Rosa A. , Mayya Y. D. , Loinard Laurent , Álamo-Martínez Karla , Heald George , Georgiev Iskren Y. , Órdenes-Briceño Yasna , Lançon Ariane , Lara-López Maritza A. , Lomelí-Núñez Luis , Bruzual Gustavo , Puzia Thomas H. 
Published: May 2019

Abstract
We present multiobject spectroscopic observations of 23 globular cluster candidates (GCCs) in the prototypical megamaser galaxy NGC 4258, carried out with the Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy instrument at the 10.4 m Gran Telescopio Canarias. The candidates have been selected based on the (u* − i′) versus (i′ − K

s
) diagram, in the first application of the u*i′K

s
method to a spiral galaxy. In the spectroscopy presented here, 70% of the candidates are confirmed as globular clusters (GCs). Our results validate the efficiency of the u*i′K

s
method in the sparser GC systems of spirals, and given the downward correction to the total number of GCs, the agreement of the galaxy with the correlations between black hole mass and the total number and mass of GCs is actually improved. We find that the GCs, mostly metal-poor, corotate with the H i disk, even at large galactocentric distances.
The Evolution of the Quenching of Star Formation in Cluster Galaxies since z ∼ 1
Authors: Pintos-Castro I. , Yee H. K. C. , Muzzin A. , Old L. , Wilson G. 
Published: May 2019

Abstract
We study the star-forming (SF) population of galaxies within a sample of 209 IR-selected galaxy clusters at 0.3 ≤ z ≤ 1.1 in the ELAIS-N1 and XMM-LSS fields, exploiting the first HSC-SSP data release. The large area and depth of these data allow us to analyze the dependence of the SF fraction, f
SF, on stellar mass and environment separately. Using R/R
200 to trace environment, we observe a decrease in f
SF from the field toward the cluster core, which strongly depends on stellar mass and redshift. The data show an accelerated growth of the quiescent population within the cluster environment: the f
SF versus stellar mass relation of the cluster core (R/R
200 ≤ 0.4) is always below that of the field (4 ≤ R/R
200 < 6). Finally, we find that environmental and mass quenching efficiencies depend on galaxy stellar mass and distance to the center of the cluster, demonstrating that the two effects are not separable in the cluster environment. We suggest that the increase of the mass quenching efficiency in the cluster core may emerge from an initial population of galaxies formed “in situ.” The dependence of the environmental quenching efficiency on stellar mass favors models in which galaxies exhaust their reservoir of gas through star formation and outflows, after new gas supply is truncated when galaxies enter the cluster.
Characterization of uropathogenic ESBL-producing Escherichia coli isolated from hospitalized patients in western Algeria
Authors: Zenati Fatima , Barguigua Abouddihaj , Nayme Kaotar , Benbelaïd Fethi , Khadir Abdelmounaïm , Bellahsene Chafika , Bendahou Mourad , Hafida Hassaïne , Timinouni Mohammed 
Published: May 2019

Introduction: The aim of this study is to assess the prevalence and molecular characterization of uropathogenic Extended spectrum β-lactamases (ESBLs) producing Escherichia coli.
Methodology: During 3 years, all hospitalized patients at the University-affiliated hospital of Tlemcen and presenting urinary tract infections caused by E. coli were considered as potential study participants. These E. coli isolates were examined phenotypically for ESBL production. ESBL strains were subjected to antimicrobial susceptibility testing and were investigated for the presence of plasmid mediated quinolone resistance genes, 16SrRNA methylase genes and virulence genes by using conventional PCR and DNA sequencing. The molecular characterization of ESBL strains was established by phylogenetic grouping method and ERIC-PCR.
Results: The overall prevalence of ESBL was 32.5%. The blaCTX-M-15 was the most frequently detected in ESBL isolates, followed by blaCTX-M-14, blaCTX-M-28, blaCTX-M-1 and blaSHV-12 respectively. The plasmid-mediated quinolone resistance genes were detected in the 15 ESBL strains with the aac(6’)-Ib-cr gene was the most detected followed by qnrB1 and qnrA1 gene respectively. Among the 22 ESBL isolates resistant to gentamicin and amikacin, the 16SrRNA methylase genes were detected in 4 isolates. The sfa and pap virulent genes were founds in 26% and 22% of isolates receptively. The genotyping analysis of all strains revealed that almost were belonged to phylogenetic groups A1 and A0 and fourteen distinct clones.
Conclusion: The emergence of uropathogenic ESBL isolates and the high rate of blaCTX-M are alarming in Algeria. Strict measure must be required to control the further spread of these strains in Algerian hospitals.
Efficiency of extraction of antioxidant compounds in by-product from red guava processing
Authors: Oliveira Silva Maira , Pastore Gláucia Maria 
Published: May 2019

Studies that investigate efficient methods for extraction of antioxidant compounds in by-products of fruits can contribute to their appreciation in human food. This study aimed comparing two methods for phenolic extraction - single extraction (single solvent) and sequential (different solvents) in by-product from Paluma guava processing, evaluating the influence of the extracts on the stabilization of radicals by DPPH and ORAC assays. Sequential extraction showed higher efficiency in obtaining phenolic (2.60 > 0.56 mg GAE g-1), allowing the extraction of free phenolic, conjugated and fat-soluble, as well as determining the highest antioxidant capacity in these extracts. Acetone was characterized to be the responsible solvent for higher extraction of phenolic in the sequential extraction, being necessary 0.90 mg mL-1 of extract to reduce 50% the action of DPPH• radicals. Thus, sequential extraction of phenolic is a potential method for better use of antioxidant compounds in the guava processing by-product.
Advancing Early Identification of Axial Spondyloarthritis: An Interobserver Comparison of Extended Role Practitioners and Rheumatologists
Authors: Passalent Laura , Hawke Christopher , Lawson Daeria O. , Omar Ahmed , Alnaqbi Khalid A. , Wallis Dinny , Steinhart Hillary , Silverberg Mark , Wolman Stephen , Derzko-Dzulynsky Larissa , Haroon Nigil , Inman Robert D. 
Published: May 2019

Objective.To compare clinical impression and confidence of extended role practitioners (ERP) with those of rheumatologists experienced in axial spondyloarthritis (axSpA) according to (1) evaluation of patients with chronic back pain assessed for axSpA; and (2) magnetic resonance imaging (MRI) recommendation for further investigation of these patients.Methods.Patients with ≥ 3 months of back pain and age of onset < 45 years were referred for axSpA evaluation. An ERP assessed consecutive patients and recorded standardized clinical information in written form. Three rheumatologists subsequently evaluated each patient based on the recorded information. Patients were classified as having axSpA or mechanical back pain based on clinical and investigative findings. Level of confidence was noted for classification and MRI indication. Agreement between assessors was evaluated using percentage agreement and κ coefficient.Results.Fifty-seven patients were assessed. Interobserver agreement of clinical impression for all raters was moderate (κ = 0.52). Agreement of clinical impression between ERP and rheumatologists ranged between 71.2% (κ = 0.41) and 79.7% (κ = 0.57). Agreement of clinical impression among rheumatologists ranged from 74.1% (κ = 0.49) to 79.7% (κ = 0.58). All rater agreement for MRI indication was fair (κ = 0.37). ERP agreement with rheumatologist for MRI recommendation ranged from 64.2% (κ = 0.32) to 75% (κ = 0.48). Agreement for MRI indication among rheumatologists ranged from 62.9% (κ = 0.27) to 74% (κ = 0.47). Confidence in clinical impression was similar among all practitioners.Conclusion.ERP with specialty training in inflammatory arthritis demonstrate clinical impressions comparable with those of rheumatologists in the assessment of axSpA. Incorporation of such roles into existing models of care may assist in early detection of axSpA.
Physical or Occupational Therapy Use in Systemic Sclerosis: A Scleroderma Patient-centered Intervention Network Cohort Study
Authors: Becetti Karima , Kwakkenbos Linda , Carrier Marie-Eve , Gordon Jessica K. , Nguyen Joseph T. , Mancuso Carol A. , Mouthon Luc , Nguyen Christelle , Rannou François , Welling Joep , Thombs Brett D. , Spiera Robert F. ,   the SPIN Investigators
Published: May 2019

Objective.Systemic sclerosis (SSc) is characterized by significant disability because of musculoskeletal involvement. Physical and occupational therapy (PT/OT) have been suggested to improve function. However, the rate of PT/OT use has been shown to be low in SSc. We aimed to identify demographic, medical, and psychological variables associated with PT/OT use in SSc.Methods.Participants were patients with SSc enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort. We determined the rate and indication of PT/OT use in the 3 months prior to enrollment. Multivariable logistic regression was used to identify variables independently associated with PT/OT use.Results.Of the 1627 patients with SSc included in the analysis, 23% used PT/OT in the preceding 3 months. PT/OT use was independently associated with higher education (OR 1.08, 95% CI 1.04–1.12), having moderately severe small joint contractures (OR 2.09, 95% CI 1.45–3.03), severe large joint contractures (OR 2.33, 95% CI 1.14–4.74), fewer digital ulcerations (OR 0.70, 95% CI 0.51–0.95), and higher disability (OR 1.54, 95% CI 1.18–2.02) and pain scores (OR 1.04, 95% CI 1.02–1.06). The highest rate of PT/OT use was reported in France (43%) and the lowest, in the United States (17%).Conclusion.Despite the potential of PT/OT interventions to improve function, < 1 in 4 patients with SSc enrolled in a large international cohort used PT/OT services in the last 3 months. Patients who used PT/OT had more severe musculoskeletal manifestations and higher pain and disability.
Are Target Urate and Remission Possible in Severe Gout? A Five-year Cohort Study
Authors: Alvarado-de la Barrera Claudia , López-López Carlos Omar , Álvarez-Hernández Everardo , Peláez-Ballestas Ingris , Gómez-Ruiz Citlallyc , Burgos-Vargas Rubén , Vázquez-Mellado Janitzia 
Published: May 2019

Objective.Determine the proportion of patients achieving target serum urate (SU), defined as < 6 mg/dl for patients with non-severe gout and < 5 mg/dl for patients with severe gout, as well as the proportion of patients achieving remission after 5 years of followup.Methods.Patients from the Gout Study Group (GRESGO) cohort were evaluated at 6-month intervals. Demographic and clinical data were obtained at baseline. Visits included assessments of serum urate, flares, tophus burden, health-related quality of life using the EQ-5D, activity limitations using the Health Assessment Questionnaire adapted for gout, and pain level and patient’s global assessment using visual analog scales. Treatment for gout and associated diseases was prescribed according to guidelines and available drugs.Results.Of 500 patients studied, 221 had severe gout (44%) and 279 had non-severe gout (56%) at baseline. No significant differences were observed across the study in percentages of severe gout versus non-severe gout patients achieving SU 6 mg/dl or 5 mg/dl. The highest proportion of patients achieving target SU (50–70%) and remission (39%) were found after 3–4 years of followup. In the fifth year, these proportions decreased and 28% of the patients were in remission, but only 40 patients remained in the study. None of the patients with severe gout achieved remission.Conclusion.In patients with severe gout, target SU was hard to achieve and remission was not possible. The main obstacles for target SU and gout remission include poor medication adherence, persistent tophi, and loss to followup.
Défaire et refaire un groupe à risque. Objectivation et prévention du sida chez les homosexuels masculins à l’ère des antirétroviraux
Authors: Trachman Mathieu , Gelly Maud , Girard Gabriel 
Published: May 2019

Au cours des années 1990, la lutte contre le VIH est devenue une cause nationale dont les actions de prévention s’adressent à l’ensemble de la population afin de prévenir toute stigmatisation. Dans les années 2000, la reconnaissance de l’existence de « groupes à risque » n’a plus posé problème et a déterminé des actions plus ciblées. Constatant la recrudescence des prises de risques, les acteurs de la prévention se sont donnés les moyens de saisir les groupes au plus près de leurs comportements. À partir du cas des homosexuels masculins, l’article analyse deux innovations récentes qui incarnent cette tendance : la démédicalisation du dépistage et la prophylaxie préexposition. Celles-ci permettent de montrer que l’évolution observée ne se résume pas à l’explicitation de ce qui devait être passé sous silence, mais suppose un travail d’objectivation renouvelé, de mobilisation d’individus appartenant à la population ciblée et d’une certaine conception de l’individu preneur de risques. Le repérage des comportements à risque permet aussi de délimiter les populations sur lesquelles il est possible d’intervenir et la mise en place d’outils pour y parvenir.
Effet d’une intervention en polarité sur l’insomnie et l’anxiété de femmes québécoises d’âge moyen
Authors: Lambert Johanne , Ouellet Nicole , Boucher Danielle 
Published: May 2019

De nombreux symptômes associés à la ménopause peuvent perturber le sommeil et occasionner de l’insomnie. Ces symptômes peuvent également s’accompagner d’anxiété et nuire à la qualité de vie des femmes. Cette étude avait pour but d’évaluer l’efficacité d’une intervention en polarité sur l’insomnie et l’anxiété des femmes âgées de 40 à 60 ans. Dans ce devis expérimental, 47 femmes ayant des symptômes d’insomnie ont été réparties aléatoirement dans un groupe expérimental (n = 25) recevant quatre séances en polarité ou dans le groupe contrôle (n = 22) recevant de l’information sur les saines habitudes de sommeil. Les données ont été recueillies avant et après l’intervention en utilisant l’Index de sévérité de l’insomnie et l’Inventaire d’anxiété situationnelle. Une différence significative a été observée entre les groupes et entre les temps de mesure en ce qui a trait aux scores d’insomnie (F = 28,66 ; p < 0,0001) et d’anxiété (F = 14,14 ; p < 0,0001). Les participantes du groupe expérimental présentent une diminution significative de la sévérité de leur insomnie et de leur niveau d’anxiété situationnelle comparativement à celles du groupe contrôle en post-intervention. Cette intervention de polarité s’est avérée efficace pour réduire l’insomnie et l’anxiété des femmes d’âge moyen.
Prise en charge des plaies chroniques par l’infirmier : état des lieux comparatif des pratiques pédagogiques dans la formation initiale au niveau national et en Lorraine
Authors: Schuster Pierre 
Published: May 2019

Introduction : la prise en charge des plaies chroniques par l’infirmier fait largement partie de son rôle propre. Cette mission complexe nécessite cependant pour les professionnels de posséder un vaste socle de connaissances. Objectif de l’étude : l’objectif est d’établir un état des lieux comparatif des pratiques pédagogiques déployées dans les Ifsi au niveau national et en Lorraine en matière de plaies chroniques. Méthode : une enquête a été réalisée à l’aide d’un questionnaire auto-administré en ligne adressé via le réseau Cefiec, entre février et avril 2018. Il comportait 21 questions. Principaux résultats : 34,8 % des Ifsi possèdent un formateur titulaire d’un diplôme universitaire en plaies et cicatrisation. Seuls 30,4 % proposent des encadrements cliniques. La préparation du lit de la plaie selon le modèle TIME et le débridement ne sont pas abordés dans respectivement 40 et 20 % des Ifsi lorrains (vs 40 et 7,5 % au plan national). Discussion : les contenus d’enseignement sont très hétérogènes et laissent entrevoir un déficit théorique et pratique, notamment pour la préparation du lit de la plaie, la détersion et la compression veineuse. La collaboration avec les infirmiers experts et l’hôpital support est fréquente. L’accès des formateurs à la formation et aux revues scientifiques est insuffisante.
Assessment of Samanea saman Whole Pod Extract as an Antimicrobial Agent and its Effect on Chicken Patties
Authors: Hagan Margaret Aba Sam , Omojola Andrews Babatunde , Donkoh Armstrong 
Published: May 2019

Purpose: Samanea saman whole pod (SSWP) has a potential to be used as an ingredient in broiler feed while its pod extract has antimicrobial properties. There is however, insufficient information on the use of Samanea saman whole pod extract (SSWPE) as antimicrobial agent in meat products. This study was aimed at assessing the antimicrobial effect of SSWPE against bacteria such as Bacillus subtilis, Staphylococcus aureus, Enterococcus feacalis, Escherichia coli, Streptococcus pyogenes, Salmonella typhi, Klebsiella pneumonia and Pseudomonas aeruginosa and assessing the potential of using SSWPE on chicken patties in order to reduce the microbial contaminants. Research Method: Agar well diffusion method and Minimum inhibition concentration (MIC) method were used to determine the antimicrobial activity in the pod extract. In order to investigate the antibacterial effect of S. saman extract in chicken patties, total plate counts and selective plate counts (to enumerate Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa) were carried out on refrigerated chicken patties stored for 1, 7 and 14 days. The data generated from the study were subjected to one-way analysis of variance (ANOVA). Results: The result of Agar well diffusion method showed that the SSWPE was active against all the tested bacteria with varying mean zones of inhibition. S. saman ethanolic whole pod extract has shown the 25 μg /ml as the minimum inhibition concentration against both Gram positive and Gram negative bacteria used in the study when compared to the standard Ciprofloxacin at 1μg /ml. The total microbial counts of the chicken patties with various treatments showed increase in total microbial counts with increment of the time of storage from day 1 to 14. Salmonella and Pseudomonas were absent in chicken patties at the day 1 and in other two sampling points (day 7 and 14) whereas Escherichia coli was present at day 1 in T4, T5 and in day 14 in T5. Original Value: Thus the extract of S. saman whole pods has a potential of serving as antimicrobial agent at the minimum inhibition concentration of 25 μg /ml.
In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis
Authors: Xu Yi , Cheng Yanmei , Baylink David J. , Wasnik Samiksha , Goel Gati , Huang Mei , Cao Huynh , Qin Xuezhong , Lau Kin-Hing William , Chan Christian , Koch Adam , Pham Linh H. , Zhang Jintao , Li Chih-Huang , Wang Xiaohua , Berumen Edmundo Carreon , Smith James , Tang Xiaolei 
Published: May 2019

Abstract
Current therapies for gut inflammation have not reached the desired specificity and are attended by unintended immune suppression. This study aimed to provide evidence for supporting a hypothesis that direct in vivo augmentation of the induction of gut-homing regulatory T (Treg) cells is a strategy of expected specificity for the treatment of chronic intestinal inflammation (e.g., inflammatory bowel disease). We showed that dendritic cells (DCs), engineered to de novo produce high concentrations of both 1,25-dihydroxyvitamin D, the active vitamin D metabolite, and retinoic acid, an active vitamin A metabolite, augmented the induction of T cells that express both the regulatory molecule Foxp3 and the gut-homing receptor CCR9 in vitro and in vivo. In vivo, the newly generated Ag-specific Foxp3+ T cells homed to intestines. Additionally, transfer of such engineered DCs robustly suppressed ongoing experimental colitis. Moreover, CD4+ T cells from spleens of the mice transferred with the engineered DCs suppressed experimental colitis in syngeneic hosts. The data suggest that the engineered DCs enhance regulatory function in CD4+ T cell population in peripheral lymphoid tissues. Finally, we showed that colitis suppression following in vivo transfer of the engineered DCs was significantly reduced when Foxp3+ Treg cells were depleted. The data indicate that maximal colitis suppression mediated by the engineered DCs requires Treg cells. Collectively, our data support that DCs de novo overproducing both 1,25-dihydroxyvitamin D and retinoic acid are a promising novel therapy for chronic intestinal inflammation.
Identification and Structure of an MHC Class I–Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells
Authors: Yamamoto Yukie , Morita Daisuke , Shima Yoko , Midorikawa Akihiro , Mizutani Tatsuaki , Suzuki Juri , Mori Naoki , Shiina Takashi , Inoko Hidetoshi , Tanaka Yoshimasa , Mikami Bunzo , Sugita Masahiko 
Published: May 2019

Abstract
Similar to host proteins, N-myristoylation occurs for viral proteins to dictate their pathological function. However, this lipid-modifying reaction creates a novel class of “lipopeptide” Ags targeted by host CTLs. The primate MHC class I–encoded protein, Mamu-B*098, was previously shown to bind N-myristoylated 5-mer peptides. Nevertheless, T cells exist that recognize even shorter lipopeptides, and much remains to be elucidated concerning the molecular mechanisms of lipopeptide presentation. We, in this study, demonstrate that the MHC class I allele, Mamu-B*05104, binds the N-myristoylated 4-mer peptide (C14-Gly-Gly-Ala-Ile) derived from the viral Nef protein for its presentation to CTLs. A phylogenetic tree analysis indicates that these classical MHC class I alleles are not closely associated; however, the high-resolution x-ray crystallographic analyses indicate that both molecules share lipid-binding structures defined by the exceptionally large, hydrophobic B pocket to accommodate the acylated glycine (G1) as an anchor. The C-terminal isoleucine (I4) of C14-Gly-Gly-Ala-Ile anchors at the F pocket, which is distinct from that of Mamu-B*098 and is virtually identical to that of the peptide-presenting MHC class I molecule, HLA-B51. The two central amino acid residues (G2 and A3) are only exposed externally for recognition by T cells, and the methyl side chain on A3 constitutes a major T cell epitope, underscoring that the epitopic diversity is highly limited for lipopeptides as compared with that for MHC class I–presented long peptides. These structural features suggest that lipopeptide-presenting MHC class I alleles comprise a distinct MHC class I subset that mediates an alternative pathway for CTL activation.
The multi-valuation Agreement Hierarchy
Authors: Shen Zheng 
Published: May 2019

This paper investigates multi-valuation, i.e. cases where one probe agrees with multiple goals thus obtaining multiple feature values. Focusing on number agreement, I look at the cross-linguistic patterns on multi-valued Ns in the nominal Right Node Raising construction (Nominal RNR) reported in Belyaev et al. (2015); Harizanov &amp; Gribanova (2015); Shen (2016) as well as multi-valued Ts in TP RNR construction reported in Yatabe (2003); Grosz (2009; 2015); Kluck (2009). I show that three types of languages are attested: languages like Serbo-Croatian that show singular marking on both multi-valued Ns and Ts, languages like Russian that show plural marking on both multi-valued Ns and Ts, and languages like English that show singular marking on multi-valued Ns and plural marking on multi-valued Ts. No language is attested that shows plural marking on multi-valued Ns and singular marking on multi-valued Ts. I use this 3/4 pattern to argue that multi-valuation shows the effect of the Agreement Hierarchy discussed by Corbett (1979; 2006) among others.