bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Epstein–Barr virus‐specific adoptive T‐cell therapy in a patient with lupus nephritis
Authors: Ranganathan Dwarakanathan , Leibowitz Saskia , John George T , Neller Michelle A , Ambalathingal George R , Beagley Leone , Panikkar Archana , Best Shannon , Raju Jyothy , Reddiex Hilary , Ratanjee Sharad , Ng Monica Suet Ying , Smith Corey , Khanna Rajiv 
Published: November 2024

AbstractObjectivesDysregulation of Epstein–Barr virus (EBV)‐specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a major risk factor for overall morbidity in SLE. Immune‐based strategies directed to EBV have been proposed as potential therapeutic strategy for SLE and lupus nephritis.MethodsAutologous EBV latent antigen‐specific CD4+ and CD8+ T cells were expanded in vitro and adoptively transferred to a lupus nephritis patient.ResultsThis adoptive immunotherapy had no immediate adverse effects, and the patient was subsequently treated with the anti‐CD20 antibody, obinutuzumab. The patient showed a reduction in anti‐dsDNA antibodies and improved glomerular filtration rate but remained nephrotic. These observations were coincident with a reduction in anti‐viral and global T‐cell activation.ConclusionTo our knowledge, this is the first report of the use of EBV‐specific adoptive immunotherapy to treat a patient with lupus nephritis.
Nonlinear Interaction and Modulational Instability of Dust Acoustic Disturbances in a Magnetized Cometary Plasma
Authors: Dutta Debjit , Kolay Debaditya 
Published: November 2024

ABSTRACTThe interplay of dust acoustic waves (DAWs) and it's amplitude modulation is investigated in a magnetized five‐component cometary plasma comprising positively charged hydrogen and oxygen ions, negatively charged dust grains, along with superthermal electrons (solar and cometary). The interplay dynamics of the dust acoustic waves (DAWs) is described by the Kortweg–de Vries (KdV) equation. The appearance of multi‐soliton profiles are derived using Hirota's method. The amplitude modulation of the DAWs is investigated through nonlinear Schrodinger equation. In the numerical study, it appears that the dark‐envelope soliton may exist in such cometary plasmas, but the emergence of bright‐envelope soliton is not possible at any condition. Superthermality, magnetic field strength, ion and electron concentration, and other physical factors have all been explored for their impacts. The findings of this research may contribute to our understanding of the nonlinear characteristics and wave propagation stability of electrostatic wave excitations in cometary coma environments.
Hybrid Whale Optimization‐Based Energy‐Efficient Lightweight Internet of Things Framework
Authors: Sinha Avishek , Singh Samayveer , Verma Harsh K. 
Published: November 2024

ABSTRACTThe wireless intelligent computing paradigm has significantly provided services to various sectors in today's technology‐driven landscape. Despite its popularity, wireless intelligent computing faces challenges in addressing time‐sensitive tasks due to the physical distance between servers from users. Edge computing has been introduced for the internet of things (IoT) as an effective complement to enhance the wireless intelligent computing capacity for handling latency‐critical tasks. However, the limited resources of IoT and edge nodes can lead to suboptimal task management. In response to these challenges, we propose a lightweight approach that leverages a hybrid technique combining the whale optimization algorithm (WOA) with adaptive inertia weight and a genetic algorithm component. This method aims to enhance the efficiency of task offloading in a cloud‐edge computing environment. Experimental results demonstrate that the proposed strategy not only addresses the limitations of traditional methods but also achieves significant improvements, a 34% increase in makespan minimization, an 11% reduction in task rejection ratio, a 17% decrease in execution cost, and a 15% improvement in energy utilization compared to WOAs. The simulation results highlight the effectiveness of the proposed hybrid algorithm in enhancing quality of service (QoS) metrics for latency‐sensitive IoT applications.
Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline
Authors: Calandri Ismael L. , Ardohain Carolina A. , Elgani Sofia A. , Seminara Emiliana , Hernandez Micaela A. , Ossenkoppele Rik , Allegri Ricardo F. 
Published: November 2024

AbstractINTRODUCTIONProviding medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice can be influenced by individual's social environment. We measured that impact within a Latinamerican population.METHODSWe recruited 183 SCD individuals from a Memory Clinic, analyzed their health‐related, and provided them with medical advice. We assessed personal network composition and its healthy habits. We evaluated adherence to medical advice 6 months later.RESULTSThe proportion of heavy drinkers in the network is a risk factor to reduce alcohol consumption (odds ratio [OR] = 31.2, 95% confidence interval [CI] [3.73,301], p = 0.002), poor diets in the network hinders improving diet (p < 0.001 OR = 74.1, 95% CI [14.7,471]), and sedentary people in the network make it difficult to start exercising (OR = 4.92 95% CI [1.39,18.8], p = 0.016).DISCUSSIONPersonal networks have an inertial effect, as relationships engaged in an unhealthy habit lower the probability of individuals to quit that habit.
Strong Small‐Scale Differentiation but No Cryptic Species Within the Two Isopod Species Asellus aquaticus and Proasellus coxalis in a Restored Urban River System (Emscher, Germany)
Authors: Weiss Martina , Lorenz Armin W. , Feld Christian K. , Leese Florian 
Published: November 2024

ABSTRACTWorldwide, humans have strongly altered river networks. Key changes resulted in modified hydromorphology, poor habitat quality and availability, migration barriers, and pollution. Restoration measures aim at mitigating anthropogenic stressors and at restoring connectivity, but the biological success of these measures is not guaranteed. Analyzing genetic diversity and metapopulation structure of target species in the river network with genetic markers can help to understand recolonization processes and to identify persisting gene flow barriers. Here, we studied the population genetic structure of the two pollution‐tolerant detritivorous isopod species, Asellus aquaticus and Proasellus coxalis, in the former heavily degraded and polluted, but now mostly restored Emscher catchment in Germany. For both species, we analyzed mitochondrial cytochrome c oxidase I (COI) gene sequences and nuclear genome‐wide single nucleotide polymorphism (SNP) data. Surprisingly, we found a strong metapopulation structure for both species with several isolated populations on a small‐scale of few kilometers, but a still high genetic diversity, especially in the COI gene. For both taxa, potentially cryptic species are known, but our SNP data showed that the mitochondrial lineages represent only one species, each, in the study area. This highlights the importance of integrating high‐resolution nuclear markers into species identification because species diversity may otherwise be overestimated. While we could identify some migration barriers and find indications for passive dispersal by birds or humans, these factors could not fully explain the local metapopulation structure, suggesting that also other drivers, such as isolation by adaptation, priority effects, or biotic interactions, play a role in shaping the population genetic structure.
A Mature Tool to Address New Challenges: Harnessing Coordination Chemistry for The Sustainable Copper Recovery from Industrial and E‐Waste in The Age of Energy Transition
Authors: Ostellari Pietro , Gross Silvia 
Published: November 2024

AbstractCopper is arguably one of the most strategic metals for the energy transition, particularly in the shift from fossil fuel‐based engines to sustainable and renewable energy sources, with related and broader electrification efforts. While global copper mineral resources are far from depleted, their uneven distribution poses significant supply risks, especially in regions like Europe. In 2023, the European Union (EU) recognized this risk by designating copper as a strategic raw material (SRM), highlighting the need for innovative copper recovery processes. Copper recovery from industrial and electronic waste has been approached through various methods, primarily categorized into pyrometallurgy and solvo‐ and hydrometallurgy. The latter offers greater tunability and potential for sustainability, particularly when leveraging coordination chemistry. This review focuses on the most promising hydrometallurgical processes for copper recovery from industrial and e‐waste (i. e., electronic waste), with a special emphasis on the role of coordination chemistry in supporting these methods. We posed particular focus on the adaptability and versatility of the coordination chemistry‐based processes to the highly heterogenous composition of the copper‐containing wastes.
Exploring the reactivity of (hetero)aryl amides in the Chan‐Evans‐Lam reaction with arylalkenyl boron reagents
Authors: Ferreira Joana R. M. , Guerreiro Bruna F. L. , Santos Fábio M. F. , Guieu Samuel , Marques M. Manuel B. 
Published: November 2024

AbstractThe unique reactivity and stability of enamides make them attractive reagents in organic synthesis. Herein, we investigated the reactivity of acetanilides and pyridyl acetamides in the formation of a C−N bond through a Chan‐Evans‐Lam reaction using arylalkenyl boron‐based reagents yielding a wide scope of N‐aryl enamides with an E configuration. The products obtained have been applied in the synthesis of N‐heterocycles, an important scaffold in several biologically active compounds, via sequential Heck reaction to prove the practical utility of the prepared N‐aryl enamides.
Tandem, Catalyst‐Free C−C Synthesis of Nitriles from Aldehydes and Methyl Cyanoacetate with Sodium Hypophosphite
Authors: Korochantsev Vasily , Fatkulin Artemy , Podyacheva Evgeniya , Boldyrev Alexander , Afanasyev Oleg I. , Chusov Denis 
Published: November 2024

AbstractSaturated carbon chain elongation is a common refrain in numerous synthetic pathways. While the formation of C−C single bonds is of primary importance in organic synthesis, the simultaneous introduction of functional groups such as nitrile or ester can reasonably increase its practical utility for the preparation of multifunctional products. The Knoevenagel reaction is a powerful tool to create carbon backbones of organic molecules; however, it requires subsequent reduction and/or decarboxylation to achieve a product with a saturated carbon chain. Herein we report a convenient one‐step protocol for the reductive condensation between methyl cyanoacetate and aldehydes in the presence of stable, ecologically benign, cheap and available in bulk amounts sodium hypophosphite as a reductant. A description of both the reaction capabilities and limitations is given in this paper.
Insights from large‐scale shake table testing: Key criticisms and potential solutions
Authors: Hayashi Kazuhiro , Nakashima Masayoshi 
Published: November 2024

AbstractThis article presents the authors' experience with large‐scale shaking table tests conducted in Japan using the E‐Defense shaking table. The discussion focuses on four criticisms often addressed regarding the utilities of large‐scale shaking table tests. Potential solutions to mitigate such criticisms are discussed based on shaking table tests conducted for a pair of three‐story wooden houses. The first criticism is that the test specimen anchored rigidly to a rigid shaking table is not a reproduction of actual structures supported by soils and foundations. A model ground was developed in a large sandbox, which occupied about 85% of the total specimen weight, supported the house, and the entire soil‐structure system was shaken. Considerable sliding occurred, having lessened the earthquake forces exerted and resultant damage to the superstructure. The second criticism is that a single specimen test, regardless of its size, cannot provide sufficient information for generalizing the behavior and performance. Empirical equations between the maximum story drift and the change in the natural frequency were developed from a series of shaking table tests. Using such empirical equations might promote quick damage assessment of individual houses when suffering from actual earthquakes. The third criticism is the importance of public appeal and eventual support from the general public to secure the budget to operate large‐scale testing facilities. The example test featured two nearly identical specimens placed on the table with different support conditions. The apparent difference in response revealed the effect of support conditions on seismic performance. The fourth criticism is the importance of increasing the number of experimental projects to balance the operation budget. Most of the preparation in the example test was accomplished in an open yard adjacent to the shaking table, and the test specimens were quickly assembled on the table using indoor cranes. The table occupation was four out of 35 weeks of the entire test duration.
The Thorny Issue of Atypical Anorexia Nervosa: Clinicians' Perspectives on How It Should Be Defined
Authors: Beard Jessica , Waller Glenn 
Published: November 2024

ABSTRACTObjectiveAtypical Anorexia Nervosa (AAN) is an ill‐defined diagnosis. Little is known about how eating disorder clinicians perceive the utility of the diagnosis, and what changes they believe would add to that utility. This qualitative study aimed to explore clinicians' perspectives on refining the DSM‐5 AAN diagnosis.MethodsContent analysis of text was used to categorise 47 responses to the questions: “What changes are required to the DSM‐5 definition of AAN?”, and “How do you think significant weight loss should be defined?”.ResultsOver 27% of clinicians advocated removing the AAN diagnosis or combining it with Anorexia Nervosa, while nearly 15% reported concerns about the requirement for ‘significant weight loss’. Over 87% of clinicians suggested ways (often inconsistent across clinicians) to define ‘significant weight loss’, with emphasis on the need for a specified rate (i.e., amount of loss/time) and consideration of physical health impacts.ConclusionClinicians broadly agree that revisions are necessary to the current AAN definition. However, while some propose specific modifications (e.g., defining ‘significant weight loss’), others advocate for the complete removal of the diagnosis. The breadth of suggestions for how to define ‘significant weight loss’ highlights the ongoing lack of consensus on AAN's relevance as a diagnostic entity.
Ensemble Multitask Prediction of Air Pollutants Time Series: Based on Variational Inference, Data Projection, and Generative Adversarial Network
Authors: Wang Kang , Qu Chao , Wang Jianzhou , Li Zhiwu , Lu Haiyan 
Published: November 2024

ABSTRACTIn light of the mounting environmental pressures, especially the significant threat urban air pollution poses to public health, there arises an imperative need to develop a data‐driven model for air pollution prediction. However, contemporary deep learning techniques, such as recurrent neural networks, often struggle to effectively capture the underlying data patterns and distributions, resulting in reduced model stability. To address this gap, this study introduces an ensemble Wasserstein generative adversarial network framework (EWGF) to enhance the stability and accuracy of PM2.5 predictions by facilitating the acquisition of more informative data representations through Wasserstein generative adversarial network. The framework contains an intricate feature extraction pipeline that automatically learns features containing residual information as representations of potential features, effectively ameliorating the underutilization of feature information. We address a nonconvex multi‐objective optimization problem associated with amalgamating diverse Wasserstein generative adversarial network architectures, which enhance the inherent instability of the predictions. Furthermore, an adaptive search strategy is introduced to ascertain the optimal distribution of prediction residuals, thereby expanding the prediction interval estimation method based on residual distribution. We rigorously evaluate the proposed framework using datasets from three major Indian cities, and our experiments unequivocally show that the EWGF outperforms existing solutions in both PM2.5 point prediction and interval prediction, evidenced by an approximate 8.07% reduction in mean absolute percentage error and an approximate 19.41% improvement in prediction interval score compared to the baseline model.
Enhanced Analysis of Carcinogens and Nutritional Profile of Vitis vinifera by Employing Pulsed Electric Field
Authors: Batool Zahra , Sameen Dur e , Wen Ding , Hu Shanshan , Roobab Ume , Li Bing , Adil Rana Muhammad , Shen Bairong 
Published: November 2024

ABSTRACTSolid Phase Microextraction‐Gas Chromatography Triple Quadrupole Mass Spectrometry (SPME‐GC‐TQ/MS) was optimized and validated to specifically analyze aldehydes and furans after drying Vitis vinifera grape variety by conventional as well as modern pre‐drying technique i.e. pulsed electric field (PEF). Analytical method was validated in terms of linearity (R2), recovery (%), relative standard deviation (% RSD), limit of detection (LOD) and limit of quantification (LOQ). Sample pre‐treatment with PEF (1 kV/cm) followed by drying at 65°C produced dried product with fewer chemical changes in the composition than convective hot air drying. Meanwhile, nutritional parameters including polyphenolics, amino acids, fatty acids and sugars profiles were also extensively investigated to get deeper insights into the effect of drying treatments on the nutritional quality of dried product. Conclusively, sample pre‐treatment on relatively lower PEF voltage, followed by drying at minimum temperature with longer time duration can preserve nutritional quality of product by forming less harmful compounds.
Enhanced sintering resistance of NiFe‐based RWGS catalysts through Cu doping
Authors: Wu Jiayi , Zhang Wenhao , Chen Hecao , Yu Weifeng , Sun Bo , Zhu Minghui , Han Yi‐Fan 
Published: November 2024

AbstractThe reverse water‐gas shift (RWGS) reaction offers an effective method for mitigating CO2 emissions. Due to its affordability and physicochemical stability, iron has garnered significant attention as a potential catalyst for RWGS. The incorporation of nickel and copper promoters can enhance CO2 conversion and CO selectivity in Fe‐based catalysts. This study focuses on modifying the strength of the Strong Metal‐Support Interaction (SMSI) through particle size optimization. Doping Cu into NiFe‐based catalysts restricts particle size, which influences the curvature of the Ni0@FeOx interface. This curvature enhances the electron coupling between Ni0 and FeOx, promoting the formation of a denser and thicker Ni0 and FeOx layer. This results in a nearly 90% increase in the CO2 reaction rate during the sintering resistance test by anchoring Ni0 and facilitating electron transfer to active sites. Such morphological evolution improves high‐temperature resistance to sintering during RWGS. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
R‐Ras1 and R‐Ras2 regulate mature oligodendrocyte subpopulations
Authors: Alcover‐Sanchez Berta , Garcia‐Martin Gonzalo , Paleo‐García Víctor , Quintas Ana , Dopazo Ana , Gruart Agnès , Delgado‐García José María , de la Villa Pedro , Wandosell Francisco , Pereira Marta P. , Cubelos Beatriz 
Published: November 2024

AbstractIn the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted that MOLs are heterogeneous; however, how MOL subpopulations are specified and balanced in physiological settings is poorly understood. Previous works have demonstrated an essential role of the small GTPases R‐Ras1 and R‐Ras2 in the survival and myelination of oligodendrocytes. In this study, we aimed to determine how R‐Ras1 and R‐Ras2 contribute to the heterogeneity of MOL subpopulations. Our results evidence that R‐Ras1 and R‐Ras2 affect specification into the distinct subpopulations MOL1, MOL2, and MOL5/6, which in turn vary in their dependence of these GTPases. In R‐Ras1 and/or R‐Ras2 mutant mice, we observed an increase in the MOL1 subpopulation and a decrease in the MOL2 and MOL5/6 subpopulations. We identified R‐Ras1 and R‐Ras2 as key elements in balancing the heterogeneity of MOLs. Our results contribute to the understanding of the molecular mechanisms underlying the heterogeneity of MOLs and the myelination processes, which is crucial for innovating regenerative therapies for nervous system disorders.
Balancing Duty, Stigma, and Caregiving Needs of People With Neurodevelopmental or Neurocognitive Disorders During a Public Health Emergency in South Asia: A Qualitative Study of Carer Experiences
Authors: Tjin Anna , Goodwin Anna , Troy Carol , Yeo Selvie , Saha Sanjib , O'Sullivan Roger , Leroi Iracema , Chen Yaohua ,   the CLIC Caregiver Study Group
Published: November 2024

ABSTRACTObjectiveIndividuals with neurodevelopmental and/or neurocognitive disorders (NNDs) have complex, long‐term care needs. In Bangladesh, India, and Pakistan, informal carers shoulder the responsibility and strain of providing care for people with NNDs. Intense care demand, societal and cultural care expectations, and lack of support infrastructure often lead to psychosocial strain in this inadequately researched community, particularly during crises such as the COVID‐19 pandemic. This study explored and identified specific features of the coping styles exhibited by informal carers of people with NNDs from Bangladesh, India, and Pakistan during the COVID‐19 pandemic.Material and methodsBetween June and November 2020, 245 carers in India, Pakistan, and Bangladesh responded to open‐ended questions in the CLIC (Coping with Loneliness, Isolation, and COVID‐19) survey. A reflexive thematic analysis was conducted to uncover the underlying themes and identify coping strategies and stressors. A frequency analysis was performed to examine the associations between these themes and carer nationality. Significant tests identified coping styles.ResultsWe identified three coping styles: religiosity (Pakistan), caregiving as a natural life path (Bangladesh), and self‐care (India). The religiosity and natural life path styles reside on the fatalism/acceptance continuum and suggest an insight‐oriented therapeutic approach. Self‐care is a problem‐solving strategy that calls for a behaviorally oriented approach. Family overreliance on the carer was a concern across all three groups.ConclusionsThe findings underscore the need for accessible support pathways to sustain care standards, ensuring the well‐being of carers and care recipients.