bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shifts in the habitat suitability for large hammerhead sharks under climate change
Authors: Santos Catarina Pereira , Borges Francisco Oliveira , Guerreiro Miguel , Pissarra Vasco , Varela Jaquelino , Frazão-Santos Catarina , Rosa Rui 
Published: November 2024

AbstractOne of the chief consequences of climate change is the worldwide redistribution of species in the pursuit of physiologically and ecologically favourable conditions. As part of one of the most threatened groups of vertebrates, assessing how climate change may affect the distribution patterns of key shark species is essential for their long-term conservation and management. The present study aims to assess how climate change projections (based on the representative concentration pathways 2.6, 4.5, 6.0, and 8.5) for the middle and end of the century may affect the global patterns of habitat suitability (HS) for large hammerhead sharks – a unique and particularly threatened group of elasmobranchs. Here, a decline in the global average HS is projected for both Sphyrna lewini and Sphyrna zygaena, with the scale of HS decline generally increasing with time and RCP severity, while a global increase in HS is generally projected for Sphyrna mokarran, albeit reduced over the long-term and overturned under long-term RCP8.5. Meanwhile, poleward shifts are projected for all three species, with considerable tropical declines for both S. lewini and S. zygaena. Additionally, regional shifts in suitability have the potential to affect population connectivity, the access to key habitats, and levels of exposure to other anthropogenic pressures, along with the effectiveness of conservation and management efforts. Taken together, these results showcase the importance of climate change for species’ extinction risk assessments and the urgency of the consideration of climate change within the design and implementation of conservation measures.
High-efficiency 5-watt wavelength-tunable UV output from an Alexandrite laser
Authors: Xiao Huaifeng , Damzen Michael J. 
Published: November 2024

AbstractWe investigate the performance of continuous-wave wavelength-tunable ultraviolet output from a diode-pumped Alexandrite laser by intra-cavity second harmonic generation. At 385 nm, ultraviolet output power of 5.05 W is achieved which is the highest continuous-wave ultraviolet power to date for intra-cavity frequency doubled diode-pumped Alexandrite lasers and highest optical-to-optical efficiency of 16.2% is achieved with respect to absorbed red pump power. An excellent ultraviolet wavelength tunable range, 38 nm, is achieved from 364 nm to 402 nm. Cavity mode analysis is performed for design of the resonator including cavity analysis and the modelling of output power from this wavelength tunable ultraviolet laser.
Does the timing of postprandial glucose monitoring affect the obstetric and neonatal outcomes in patients with gestational diabetes? A prospective study comparing 1 and 2-h postprandial monitoring
Authors: Ben Shoshan Noa , Mizrachi Yossi , Tamayev Liliya , Ben-Ari Tal , Weiner Eran , Barda Giulia 
Published: November 2024

Abstract
Objective
The aim of this study was to examine the obstetrical and neonatal outcomes in patients with gestational diabetes mellitus (GDM) who had postprandial glucose monitoring 1 vs. 2 h following meals.

Study design
In this prospective cohort study, we included patients with GDM who were referred to our medical center between July 2019 and June 2021. Patients chose the timing of postprandial glucose monitoring based on their own preferences. Obstetrical and neonatal outcomes, as well as patient satisfaction, were compared between patients who performed postprandial glucose monitoring 1 and 2 h after meals (PPG1 vs. PPG2). The primary outcome was birth weight. The study was powered to detect a 250 g increase in birth weight.

Results
Overall, 99 patients were included: 50 in the PPG1 group and 49 in the PPG2 group. Baseline characteristics were comparable between the groups. Neonates in the PPG1 and PPG2 groups had similar birth weights (3319 ± 355 vs. 3319 ± 520 g, respectively, p = 0.99). Glycemic control, mode of delivery, gestational age at delivery, and satisfaction rates were also similar between the study groups.

Conclusion
In patients with GDM, performing1 vs. 2 h following meals resulted in similar obstetrical and neonatal outcomes and similar satisfaction rates. We therefore recommend counseling patients to choose either strategy based on their personal preference.
Evaluation of a novel forward-looking optical coherence tomography probe for endoscopic applications: an ex vivo feasibility study
Authors: Jacobs Femke J. C. , Groenhuis Vincent , de Jong Ibeltje M. , Nagtegaal Iris D. , Rovers Maroeska M. , Bulte Geert J. , Fütterer Jurgen J. 
Published: November 2024

Abstract
Background
As a result of recent advances in the development of small microelectromechanical system mirrors, a novel forward-looking optical coherence tomography (OCT) probe with a uniquely large field of view is being commercially developed. The aim of this study is to prospectively assess the feasibility of this advanced OCT probe in interpreting ex vivo images of colorectal polyp tissue and to identify necessary steps for further development.

Methods
A total of 13 colorectal lesions from 9 patients, removed during endoscopic resection, were imaged ex vivo with the OCT device and compared with histopathological images that served as the gold standard for diagnostics. Normal tissue from one patient, removed during the endoscopic procedure, was imaged as a negative control. We assessed the presence of features indicative for polyp type and degree of dysplasia, by comparing OCT images to histopathological images and by evaluating the presence of OCT-specific features identified by previous studies, such as effacement (loss of layered tissue structure), a hyperreflective epithelial layer, and irregularity of the surface.

Results
As verified by corresponding histological images, tissue structures such as blood vessels and tissue layers could be distinguished in OCT images of the normal tissue sample. Detailed structures on histological images such as crypts and cell nuclei could not be identified in the OCT images. However, we did identify OCT features specific for colorectal lesions, such as effacement and a hyperreflective epithelial layer. In general, the imaging depth was about 1 mm.

Conclusion
Some relevant tissue structures could be observed in OCT images of the novel device. However, some adaptations, such as increasing imaging depth using a laser with a longer central wavelength, are required to improve its clinical value for the imaging of colorectal lesions.

Graphical abstract
Polynomial approximation of discounted moments
Authors: Zhao Chenyu , van Beek Misha , Spreij Peter , Ba Makhtar 
Published: November 2024

AbstractWe introduce an approximation strategy for the discounted moments of a stochastic process that can approximate the true moments for a large class of problems. These moments appear in pricing formulas of financial products such as bonds and credit derivatives. The approximation relies on a high-order power series expansion of the infinitesimal generator and draws parallels with the theory of polynomial processes. We demonstrate applications to bond pricing and credit derivatives. In the special cases that allow an analytical solution, the approximation error decreases to around 10 to 100 times machine precision for higher orders. When no analytical solution exists, we numerically compare the approximation with existing numerical techniques.
Antidiabetic, anti-inflammatory, antioxidant, and cytotoxicity potentials of green-synthesized zinc oxide nanoparticles using the aqueous extract of Helichrysum cymosum
Authors: Nkemzi Achasih Q. , Okaiyeto Kunle , Oyenihi Omolola , Opuwari Chinyerum S. , Ekpo Okobi E. , Oguntibeju Oluwafemi O. 
Published: November 2024

AbstractThe current research involved the synthesis of zinc oxide nanoparticles (ZnO-NPs) using an aqueous extract of Helichrysum cymosum shoots, and subsequent characterization via different analytical methods, such as UV–Vis spectroscopy, Scanning electron microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Transmission electron microscope (TEM), and zeta potential. The biological effects of the ZnO-NPs were then tested against C3A hepatocyte cells and L6 myocyte cell lines via series of analysis, including cytotoxicity, antioxidant, anti-inflammatory, and antidiabetic effect via enzymatic inhibition. The UV–Vis analysis showed a maximum absorption spectrum at 360, and the TEM analysis reveals a spherical and hexagonal structures, with an average dimension of 28.05–58.3 nm, and the XRD reveals a crystalline hexagonal structure. The zeta potential evaluation indicated that the ZnO-NPs are relatively stable at − 20 mV, and the FTIR analysis identified some important functional group associated with phenolics, carboxylic acid, and amides that are responsible for reducing and stabilizing the ZnO-NPs. The synthesized ZnO-NPs demonstrated cytotoxic effects on the cell lines at higher concentrations (125 µg/mL and 250 µg/mL), complicating the interpretation of the results of the inflammatory and antioxidant assays. However, there was a significant (p < 0.05) increase in the inhibitions of pancreatic lipase, alpha-glucosidase, and alpha-amylase, indicating beneficial antidiabetic effects.
Development and validation of a tumor size-stratified prognostic nomogram for patients with gastric signet ring cell carcinoma
Authors: Hui Xin , Zhou Guangbo , Zheng Ya , Wang Yuping , Guo Qinghong 
Published: November 2024

AbstractGastric signet ring cell carcinoma (GSRC) is a rare malignancy without a commonly acknowledged prognostic assessment and treatment system. This study aimed to determine the optimal cut-off value of tumor size (TS), and construct a prognostic nomogram in combination with other independent prognostic factors (PFs) to predict 3 year and 5 year overall survival (OS) in GSRC patients. From the Surveillance, Epidemiology, and End Results (SEER) database, this study collected 4744 patients diagnosed with GSRC. These patients were randomized into a training cohort (n = 2320,) and a validation cohort (n = 1142). A restricted cubic spline (RCS) was used to determine the cut-off value for TS, and univariate and multivariate Cox regression analyses were performed in the training cohort to identified significant predictors. A prognostic nomogram was constructed to predict OS at 3 and 5 years. Concordance index (C index), receiver operating characteristics curve (ROC curve), area under curve (AUC), and calibration curve were used to test the predictive accuracy of the model. A non-linear relationship was observed between TS and the risk of OS in GSRC, with TS thresholds at 4.4 cm and 9.6 cm. Survival was significantly lower in GSRC patients with TS > 4.4 cm. Age, marriage, chemotherapy, surgery, TS, SEER stage, regional lymph node status, and total number were independent predictors of OS. The C index in the training cohort was 0.748, and the AUC values for both 3- and 5-year OS were higher than 0.80. Similar results were observed in the validation cohort. In addition, the calibration curves showed good agreement between the predicted 3 year and 5 year OS and the actual OS. TS is a key prognostic factor for patients with GSRC, and patients with a TS of 4.4–9.6 cm and > 9.6 cm may have a poorer prognosis than those with a TS of < 4.4 cm. The TS-stratified nomogram we constructed and validated has favorable accuracy and calibration precision, and may be helpful in predicting the survival rate of patients.
Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile
Authors: Campos Jonas , Sampaio-Marques Belém , Santos Diogo , Barata-Antunes Sandra , Ribeiro Miguel , Serra Sofia C. , Pinho Tiffany S. , Canto-Gomes João , Marote Ana , Cortez Margarida , Silva Nuno A. , Michael-Titus Adina T. , Salgado António J. 
Published: November 2024

Abstract
Background:
Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation of MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming MSCs to produce higher levels of trophic factors may be instrumental to facilitate translation of current MSC therapies. We developed and tested a novel molecular priming paradigm using docosahexaenoic acid (DHA) to prime adipose tissue-derived mesenchymal stromal cells (ASCs) to enhance the secretome neuroregulatory potential.

Methods:
Comprehensive dose–response and time-course assays were carried to determine an optimal priming protocol. Secretome total protein measurements were taken in association with cell viability, density and morphometric assessments. Cell identity and differentiation capacity were studied by flow cytometry and lineage-specific markers. Cell growth was assessed by trypan-blue exclusion and senescence was probed over time using SA-β-gal, morphometry and gene expression. Secretomes were tested for their ability to support differentiation and neurite outgrowth of human neural progenitor cells (hNPCs). Neuroregulatory proteins in the secretome were identified using multiplex membrane arrays.

Results:
Priming with 40 µM DHA for 72 h significantly enhanced the biosynthetic capacity of ASCs, producing a secretome with higher protein levels and increased metabolic viability. DHA priming enhanced ASCs adipogenic differentiation and adapted their responses to replicative senescence induction. Furthermore, priming increased concentrations of neurotrophic factors in the secretome promoting neurite outgrowth and modulating the differentiation of hNPCs.

Conclusions:
These results provide proof-of-concept evidence that DHA priming is a viable strategy to improve the neuroregulatory profile of ASCs.
Hybrid heating in the fused filament fabrication process
Authors: Savu Ionel Danut , Savu Sorin Vasile , Sirbu Nicusor-Alin 
Published: November 2024

AbstractAltering the heating regime of the polymer during the fused filament fabrication (FFF) process can lead to changes in both the behaviour of the polymer and the characteristics of the printed product. This study proposes replacing the traditional resistive heating system with two hybrid systems that introduce an additional temperature of 120–160 °C: one combining resistive and hot air jet heating, and the other combining resistive and infrared radiation heating. The samples printed using these hybrid systems were analysed using differential scanning calorimetry (DSC) and visually inspected. Commercial ABS and PLA filaments were used in the experimental programme. A model to evaluate the polymer’s melting during the printing process was proposed and experimentally validated. Visual testing revealed that the printed lattice structure had smaller voids, characterised by depositions that were flattened rather than circular in cross-section due to the extended time in a viscous/partially molten state. The elongation viscosity and storage modulus decreased by approximately 10%, with a slightly smaller decrease observed for the infrared radiation heat source. The glass transition temperature remained unchanged, and the molecular mobility was not affected by the additional heat. Similarly, the energy required for crystal formation was unaffected by the supplementary heat. The mechanical behaviour of the printed pieces during compression tests was also influenced by the addition of a second heat source. For both materials, a decrease in deformability was observed as the temperature of the hot air jet increased.
Defect Engineering with Rational Dopants Modulation for High-Temperature Energy Harvesting in Lead-Free Piezoceramics
Authors: Xi Kaibiao , Guo Jianzhe , Zheng Mupeng , Zhu Mankang , Hou Yudong 
Published: November 2024

AbstractHigh temperature piezoelectric energy harvester (HT-PEH) is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors. However, simultaneously excellent performances, including high figure of merit (FOM), insulation resistivity (ρ) and depolarization temperature (Td) are indispensable but hard to achieve in lead-free piezoceramics, especially operating at 250 °C has not been reported before. Herein, well-balanced performances are achieved in BiFeO3–BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese doping. Due to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization, regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole, comprehensive excellent electrical performances (Td = 340 °C, ρ250 °C > 107 Ω cm and FOM250 °C = 4905 × 10–15 m2 N−1) are realized at the solid solubility limit of manganese ions. The HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250 °C with high energy conversion efficiency (η = 11.43%). These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements, paving a new way in developing self-powered wireless sensors working in HT environments.
Rechtsradikale Literaturpolitik als metapolitische Praxis in den 1950er und 1960er Jahren
Authors: Müller Yves , Müller-Zetzsche Marie 
Published: November 2024

Zusammenfassung
Das Konzept der Metapolitik, das den Handlungsspielraum der radikalen Rechten erweitern soll, wird der Neuen Rechten zugeschrieben. Metapolitische Strategien entwickelten Akteure wie Hans Grimm, Arthur Ehrhardt und Herbert Böhme allerdings schon in den 1950er und 1960er Jahren. Sie schufen eine alternative Publikationslandschaft und förderten rechtsradikale Netzwerke, die mehrere Generationen prägten.
Productivity Loss Associated with Disability from Migraine: A Canada-Wide Cross-Sectional Study
Authors: Naik Hiten , Tam Alexander C.T. , Trenaman Logan , Lynd Larry , Zhang Wei 
Published: November 2024

ABSTRACT

Background:
Migraine can affect adults during their most productive years, yet few studies in Canada have examined the relationship between migraine-related disability and productivity loss. In particular, the impact of migraine on unpaid productivity loss has not been quantified.

Methods:
In this cross-sectional study, employed adults living with migraine were recruited from across Canada to complete a web-based questionnaire. Migraine-related disability was assessed using the Migraine Disability Assessment questionnaire, and productivity loss was evaluated using the Valuation of Lost Productivity questionnaire. Multiple regression models were used to quantify the association between migraine-related disability level and productivity loss after adjusting for relevant clinical, occupational and sociodemographic covariates.

Results:
There were 441 participants, of which 60.1% were female, and the mean (SD) age was 37.7 (10.9). Compared to participants with little to no migraine-related disability, hours of total productivity loss were higher among those with moderate disability (54.1 [95% CI: 10.2–98.1] adjusted hours per 3 months) and severe disability (110.5 [95% CI: 65.5–155.6] adjusted hours per 3 months); paid productivity loss was higher among participants with moderate disability (32.4 [95% CI: 3.1–61.8] adjusted hours per 3 months) and severe disability (61.6 [95% CI: 31.5–91.7] adjusted hours per 3 months); and unpaid productivity loss was greater in those with severe disability (43.5 [95% CI: 12.7–74.3] adjusted hours per 3 months).

Conclusions:
Greater migraine-related disability was associated with more total, paid and unpaid productivity loss among employed adults. These data will be valuable when evaluating the cost-effectiveness of emerging migraine therapies.
A multi-task deep reinforcement learning-based recommender system for co-optimizing energy, comfort, and air quality in commercial buildings with humans-in-the-loop
Authors: Xia Stephen , Wei Peter , Liu Yanchen , Sonta Andrew , Jiang Xiaofan 
Published: November 2024

Abstract
We introduce a novel human-centric deep reinforcement learning recommender system designed to co-optimize energy consumption, thermal comfort, and air quality in commercial buildings. Existing approaches typically optimize these objectives separately or focus solely on controlling energy-consuming building resources without directly engaging occupants. We develop a deep reinforcement learning architecture based on multitask learning with humans-in-the-loop and demonstrate how it can jointly learn energy savings, comfort, and air quality improvements for different building and occupant actions. In addition to controlling typical building resources (e.g., thermostat setpoint), our system provides real-time actionable recommendations that occupants can take (e.g., move to a new location) to co-optimize energy, comfort, and air quality. Through real deployments across multiple commercial buildings, we show that our multitask deep reinforcement learning recommender system has the potential to reduce energy consumption by up to 8% in energy-focused optimization, improve all objectives by 5–10% in joint optimization, and improve thermal comfort by up to 21% in comfort and air quality-focused optimization compared to existing solutions.
Evaluation of Nurses’ Competency, Motivation, and Stress Levels in Disaster Management
Authors: Kula Şahin Sennur , Aydin Zehra 
Published: November 2024

Abstract

Objectives
This study was conducted to determine the relationships between nurses’ competency, motivation, and stress levels in disaster management, as well as to shed light on the establishment of effective disaster management programs.

Methods
In our research we used a correlational, descriptive, cross-sectional design. The sample of the study was composed of 498 nurses working in Turkey. The “Descriptive and Professional Characteristics and Disaster Experiences of Nurses” form, the “Competencies for Disaster Nursing Management Questionnaire,” the “Perceived Stress Scale,” and the “Nurses Job Motivation Scale” were used in data collection.

Results
Nurses’ disaster management competency and motivation levels were found to be adequate, and their stress levels were found to be moderate. A weak positive correlation was found between disaster management competency and motivation, but a weak negative correlation was found between stress levels. Age, education level, experience level, training in disaster nursing, and knowledge of duties and responsibilities in disasters were associated with significant differences in terms of disaster competency and its dimensions, motivation, and stress levels.

Conclusions
The study found that nurses’ disaster experiences impacted their competency, feeling of preparedness, and stress and motivation levels, and motivation was found to be a predictor of increasing competency.
All Pandemics are Local: The Importance of a Culture-Centered Approach to Risk and Crisis Communication for Laboratory Research on Zoonotic Diseases
Authors: Rascon Natasha , Myers Nathan , Johnson Malynnda 
Published: November 2024

Abstract
Continuing laboratory research into zoonotic diseases is necessary for public health preparedness. However, the COVID-19 pandemic has elevated existing concerns about the risks BSL-4 research facilities can pose to the surrounding community. This study places such concerns in the context of previous research regarding the construction of biosafety labs, as well as policy discussions related to other scientific controversies like gain of function research. Building on this prior knowledge as well as established theories in the field of communication, we propose using a Culture-Centered Approach paired with a Communication Complex approach to facilitate more meaningful and effective communication between researchers and community members, particularly those who tend to be marginalized in such conversations. The commentary concludes by outlining a risk assessment process using the CCA-Communication Complex Approach.