bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voluntary disclosure of environmental performance after regulatory change
Authors: Shima Kim , Fung Scott 
Published: April 2019

PurposeThe purpose of this study is to use recent US legislative activity surrounding changes to the Environmental Protection Agency (EPA)/Clean Air Act in 2010, which changes the practice of environmental policy of a firm, and the unique setting of Utility industry to examine the relationship between a firm’s voluntary accounting disclosure and environmental performance.Design/methodology/approachThis study features hand-collected data of environmental disclosure and examines its relation with environmental performance. To address the endogeneity problem, a difference-in-differences test with propensity score matching is performed to study the impact of policy change on environmental disclosure.FindingsThe findings of this study show that measures of environmental performance have a significant and positive association with a firm’s voluntary disclosure. The results from difference-in-differences test show that adjustments in environmental performance after regulatory change have a causal and positive effect on a firm’s voluntary disclosure.Research limitations/implicationsThe findings support theories of signaling and voluntary disclosure that better-performing firms provide more information disclosure of their environmental performance.Practical implicationsThe findings show real adjustments in firm environmental performance and consistent voluntary disclosure around the enactment of environmental legislation, which may have important implications for environmental rule making bodies and management about the effectiveness of their regulations.Originality/valueThis study is among the first to examine the causal relationship between environmental performance and disclosure within the context of recent changes in US environmental regulation. This study also provides the Utility industry experiment with difference-in-differences test to tackle endogeneity in the relation between performance and disclosure.
A narrative on integrating research and theory into undergraduate accounting curriculum
Authors: Baker Ron , Wick Sara 
Published: April 2019

Purpose
This paper aims to describe an effort to integrate accounting research and theory into an undergraduate accounting education program through the development and delivery of a fourth-year course. Informing ideas for the course design and content are discussed, and feedback from the students and instructor is provided.

Design/methodology/approach
This paper takes the form of a commentary and offers the authors’ opinion based on the experience of designing and teaching the course. An in-class survey was conducted in three separate offerings of the course.

Findings
Student response to the course and material was more positive than anticipated, indicating that undergraduate accounting students are receptive to learning about research and theory, even when it is not required for entrance into a professional certification program. Also, many students often went above and beyond the course requirements in the work they submitted. This indicates that there is an appetite for engaging with material that presents accounting as a social phenomenon rather than solely as a technical activity.

Research limitations/implications
While the data were collected over multiple years, the survey was conducted at a single university. These findings have implications for the design of undergraduate accounting education programs and, potentially, for addressing the gap between accounting research and practice.

Originality/value
This review contributes to the discourse on integrating research into undergraduate accounting education as recommended by the AAA Pathways Commission. It describes one method of doing so and identifies the literature that informed the approach taken. This paper also contributes to the accounting education literature by providing evidence of student reaction to a course that uses research and theory as a subject matter rather than a pedagogical tool. This evidence may also inform the teaching –research nexus discourse.
Influence of multiple slips and chemical reaction on radiative MHD Williamson nanofluid flow in porous medium
Authors: Acharya Nilankush , Das Kalidas , Kundu Prabir Kumar 
Published: April 2019

Purpose
The purpose of this paper is to focus on the influence of multiple slips on MHD Williamson nanofluid flow embedded in porous medium towards a linearly stretching sheet that has been investigated numerically. The whole analysis has been carried out considering the presence of nth-order chemical reaction between base fluid and nanoparticles.

Design/methodology/approach
A similarity transformation technique has been adopted to convert non-linear governing partial differential equations into ordinary ones and then they are solved by using both the RK-4 method and Laplace transform homotopy perturbation method. The consequences of multiple slip parameters on dimensionless velocity, temperature and concentration and heat and mass transfer rates have been demonstrated using tabular and graphical outline.

Findings
The investigation explores that the Nusselt number reduces for escalating behaviour of velocity slip and thermal slip parameter. Fluid’s temperature rises in the presence of generative reaction parameter.

Originality/value
A fine conformity of the current results has been achieved after comparing with previous literature studies. Considering destructive chemical reaction, reduced Nusselt number is found to decrease, but reverse consequence has been noticed in the case of generative chemical reaction. Mass transport diminishes when the order of chemical reaction amplifies for both destructive and generative reactions.
Scoping review: Interventions that promote functional performance for adolescents and adults with Intellectual and Developmental Disabilities
Authors: Waldman‐Levi Amiya , Golisz Kathleen , Swierat Richard P. , Toglia Joan 
Published: April 2019

IntroductionIndividuals with Intellectual and Developmental Disabilities (IDD) experience broad impairments that affect their functional performance and consequently result in the need for supervision and assistance on a daily basis. The literature contains effectiveness studies of functional interventions provided to adolescents and adults with IDD. However, existing differences in participant characteristics, study design, and type of functional intervention limit the ability to derive clinical evidence‐based decisions. This scoping review sought to explore the breadth and depth of evidence related to interventions designed to promote everyday performance of adolescents and adults with IDD.MethodsWe conducted an electronic and hand search that yielded 1568 papers, after an extensive selection process reduced to a sample of 24 studies.ResultsA three‐step extraction process of the 24 studies revealed 16 studies used functional training and technology‐based approaches to teach individuals with IDD functional skills. Seven studies used functional training without a technology component, and two studies used functional training while comparing technology‐based to non‐technology based approaches. Overall, it appeared that functional training with the use of technology, especially Video Modelling (VM) and Prompting, were the most frequently and effectively used interventions to promote everyday performance. Gaps in research include limited studies on middle and older aged adults with moderate to severe IDD, minimal use of self‐chosen goals or activities and use of technology as a continuous support.ConclusionOur findings show a lack of studies for individuals age 30 and above with severe IDD. Additionally, this scoping review highlight that everyday functional performance of adolescents and adults with IDD can be enhanced with the usage of technology based functional interventions utilising VM and prompting methods.
Integrating genetic mutations and expression profiles for survival prediction of lung adenocarcinoma
Authors: Song Yueqiang , Chen Donglai , Zhang Xi , Luo Yuping , Li Siguang 
Published: April 2019

BackgroundLung adenocarcinoma (LUAD) is a set of heterogeneous diseases with distinct genetic and transcriptomic characteristics. Since the introduction of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society histologic classification, increasing evidence has provided insights into genomic mutations and rearrangements among individual histologic subtypes of LUAD. However, how genotypic and phenotypic features of LUAD are interconnected is not well understood.MethodsWe obtained the genomic, transcriptomic, and clinical data sets of 488 LUAD patients from The Cancer Genome Atlas database. Advanced statistical models were used to disentangle the interactions between genetic mutations and expression profiles, and to assess the alterations and changes in expression of each histologic subtype. The prognostic impacts of genetic mutations, expression profiles, and clinicopathological features were integrated to predict the outcomes of LUAD patients.ResultsFrom our data, one or more genetic mutations correlate with expression levels of 6054/18175 (33.3%) genes and explain 8–40% of observed variability in LUAD. The genetic mutations and expression profiles varied remarkably among the histologic subtypes of LUAD, which helped to explain the different prognostic impact based on subtype classification. Genomic, transcriptomic, and clinical data were all shown to have utility for predicting overall and recurrence‐free survival, with the largest contribution from the transcriptome.ConclusionOur prediction model integrating genetic mutations, expression profiles, and clinicopathological features exhibited superior accuracy over the current tumor node metastasis staging system to prognosticate outcomes of patients with LUAD (overall survival 67% vs. 55%, recurrence‐free survival 57% vs. 49%; P < 0.01).
When and how does a single ventricular premature beat initiate and terminate supraventricular tachycardia?
Authors: Cunha Guerra Magno , Lokhandwala Yash , Oyarzun Rodulfo , Vyas Aniruddha , Soares Correa Frederico , Cruz Filho Fernando Eugenio , J.Wellens Hein , Back Sternick Eduardo 
Published: April 2019

AbstractBackgroundThe differential diagnosis of a supraventricular tachycardia (SVT) is accomplished using a number of pacing maneuvers. The incidence and mechanism of a single ventricular premature beat (VPB) on initiation and termination of tachycardia were evaluated during programmed electrical stimulation (PES) of the heart in patients with the two most common regular SVTs: atrioventricular re‐entrant tachycardia (AVNRT) and orthodromic atrioventricular tachycardia (AVRT).MethodsThree hundred and thirty‐seven consecutive patients aged above 18 years with an inducible sustained AVNRT or AVRT were prospectively enrolled. Patients with more than one tachyarrhythmia mechanism were excluded. Two hundred and seventeen patients (64.4%) had typical slow/fast AVNRT and 120 (35.6%) had an orthodromic AVRT using a rapidly conducting accessory pathway for V‐A conduction. In this cross‐sectional study, we specifically report the analysis of tachycardia induction and termination by a single VPB.ResultsTachycardia induction with a single VPB during sinus rhythm was seen in 7 of 120 AVRT and in only one of the 217 patients with AVNRT, (5.8% vs. 0.3%, p < 0.05). When a single VPB was delivered during basic ventricular pacing these values were 28% versus 4%, respectively, (p < 0.001). Termination of tachycardia by a single VPB was observed in nine (4.1%) patients with AVNRT and in 57 (47.5%) with AVRT (p < 0.001).ConclusionInitiation of SVT by a single VPB during sinus rhythm was uncommon and favored AVRT. Termination of SVT by a single VPB was commonly seen in AVRT but rarely in AVNRT. These findings can be of help when interpreting a noninvasive arrhythmia event recording.
Performance assessment to investigate the domain specificity of instructional skills among pre‐service and in‐service teachers of mathematics and economics
Authors: Jeschke Colin , Kuhn Christiane , Lindmeier Anke , Zlatkin‐Troitschanskaia Olga , Saas Hannes , Heinze Aiso 
Published: April 2019

BackgroundKey elements of instructional quality include the teacher's ability to immediately react in domain‐specific classroom situations. Such skills – defined as action‐related skills – can only be validly assessed using authentic representations of real‐life teaching practice. However, research has not yet explained how teachers apply domain‐specific knowledge for teaching and to what extent action‐related skills are transferable from one domain to another.AimsOur study aims to examine (1) the relationship between action‐related skills, content knowledge, and pedagogical content knowledge, and (2) the domain specificity of action‐related skills of (prospective) teachers in the two domains of mathematics and economics.Sample(s)We examined German pre‐service and in‐service teachers of mathematics (N = 239) and economics (N = 321), including n = 96 (prospective) teachers who teach both subjects.MethodsAction‐related skills in mathematics and economics were measured using video‐based performance assessments. Content knowledge and pedagogical content knowledge were assessed using established paper–pencil tests. Correlation analyses, linear regressions, and a path model were applied.ResultsIn mathematics and economics, we find a similar pattern of moderate correlations between action‐related skills, content knowledge, and pedagogical content knowledge. Moreover, a significant correlation between action‐related skills in mathematics and economics can be explained almost entirely by underlying relations between content knowledge and pedagogical content knowledge in both domains.ConclusionsOur findings suggest that action‐related skills empirically differ from domain‐specific knowledge and should be considered as domain‐specific constructs. This indicates that teacher education should not only focus on domain‐specific teacher knowledge, but may also provide learning opportunities for action‐related skills in each domain.
Asset bubbles, labour market frictions and R&D‐based growth
Authors: Hashimoto Ken‐ichi , Im Ryonghun 
Published: April 2019

AbstractEmploying an overlapping generations model of R&D‐based growth with labour market frictions, this paper examines how employment changes induced by labour market frictions influence asset bubbles and long‐run economic growth. Asset bubbles can (cannot) exist when the employment rate is high (low), which leads to higher (lower) economic growth through labour market efficiency. We also explore the steady state and transitional dynamics of bubbles, economic growth and employment. Furthermore, we show that policy or parameter changes with a negative influence on the labour market can lead to a bubble burst.
Predictors of dental care utilization in north‐central Appalachia in the USA
Authors: Chen Mengxia , Wright Casey D. , Tokede Oluwabunmi , Yansane Alfa , Montasem Alexander , Kalenderian Elsbeth , Beaty Terri H. , Feingold Eleanor , Shaffer John R. , Crout Richard J. , Neiswanger Katherine , Weyant Robert J. , Marazita Mary L. , McNeil Daniel W. 
Published: April 2019

AbstractObjectivesDental utilization is an important determinant of oral health and well‐being. The aim of this study was to evaluate potential associations between a variety of biopsychosocial factors and dental utilization in north‐central Appalachia, USA, a region where oral health disparities are profound.MethodsThis study used household‐based data from the Center for Oral Health Research in Appalachia (COHRA1) study in north‐central Appalachia, including 449 families with 868 adults. The generalized estimating equation (GEE) approach was used to determine the best‐fitting predictor model for dental utilization among adult family members.ResultsOn average across West Virginia and Pennsylvania, having dental insurance was associated with greater dental utilization over a 3‐year time period (OR = 2.20, 95% CI = 1.54, 3.14). When stratified by state, the association held for only West Virginia (OR = 2.41, 95% CI = 1.54, 3.79) and was nonsignificant for Pennsylvania residents (OR = 1.50, 95% CI = 0.80, 2.79). Individuals from Pennsylvania were more likely to utilize dental care and participants from West Virginia less so (2.31, 95% CI = 1.57, 3.40). Females from Pennsylvania were more likely than males to regularly seek dental care (OR = 1.44, 95% CI = 1.00, 2.05), and a higher income was associated with greater frequency of regular dental visits (OR = 1.21, 95% CI = 1.09, 1.34) in West Virginia. Individuals from Pennsylvania who scored higher on the Physiological Arousal subscale of the Dental Fear Survey were more likely to attend routine care visits (OR = 1.18, 95% CI = 1.03, 1.35). Across both states, more fatalistic beliefs related to oral health care also predicted less routine care (OR = 0.87, 95% CI = 0.81, 0.94), and more investment in or more positive attitudes towards one's oral health also was associated with higher utilization (OR = 1.18, 95% CI = 1.13, 1.23).ConclusionsOverall, the findings of this study suggest state residency, sex, insurance, income, fatalistic beliefs, health values, and aspects of dental care‐related anxiety and fear predicted dental care utilization in north‐central Appalachia. These findings reinforce the need to address insurance and other economic factors affecting utilization and to consider how individual‐level fatalistic beliefs and oral health values may affect utilization of routine oral health care.
Emerging viruses and current strategies for vaccine intervention
Authors: Afrough B , Dowall S , Hewson R 
Published: April 2019

Summary
During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking concern regarding their sustained epidemic transmission in immunologically naive human populations. With each new threat comes the call for rapid vaccine development. Indeed, vaccines are considered a critical component of disease prevention for emerging viral infections because, in many cases, other medical options are limited or non-existent, or that infections result in such a rapid clinical deterioration that the effectiveness of therapeutics is limited. While classic approaches to vaccine development are still amenable to emerging viruses, the application of molecular techniques in virology has profoundly influenced our understanding of virus biology, and vaccination methods based on replicating, attenuated and non-replicating virus vector approaches have become useful vaccine platforms. Together with a growing understanding of viral disease emergence, a range of vaccine strategies and international commitment to underpin development, vaccine intervention for new and emerging viruses may become a possibility.
Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease
Authors: Toulis Konstantinos A. , Viola David , Gkoutos George , Keerthy Deepiksana , Boelaert Kristien , Nirantharakumar Krishnarajah 
Published: April 2019

AbstractContextThe incidence of differentiated thyroid cancer (DTC) is increasing, yet the prognosis is favourable and long‐term survival is expected. Exogenous TSH suppression has been used for many years to prevent DTC recurrence and may be associated with increased risks of circulatory diseases.DesignRisks of circulatory disease in patients treated for DTC were compared to randomly matched patients without DTC (controls) up to a 1:5 ratio using age, sex, body mass index (BMI) and smoking as the matching parameters in a population‐based, open cohort study using The Health Improvement Network.PatientsA total of 3009 patients treated for DTC with no pre‐existing cardiovascular disease were identified and matched to 11 303 controls, followed up to median of 5 years.ResultsA total of 1259 incident circulatory events were recorded during the observation period. No difference in the risk of ischaemic heart disease (IHD) (adjusted hazards ratio [aHR]: 1.04, 95% CI: 0.80‐1.36) or heart failure (HF) (aHR: 1.27, 95% CI: 0.89‐1.81) was detected. The risk of atrial fibrillation (AF) and stroke was significantly higher in patients with DTC (aHR: 1.71, 95% CI: 1.36‐2.15 and aHR: 1.34, 95% CI: 1.05‐1.72, respectively). In a sensitivity analysis limited to newly diagnosed patients with DTC, only the risk of AF was consistently elevated (aHR: 1.86, 95% CI: 1.33‐2.60).ConclusionsThe increased risk of AF in patients who have undergone treatment for DTC but without pre‐existing CVD may warrant periodic screening for this arrhythmia. Whereas no evidence of increased risk of IHD or HF was observed, the increased risk of stroke/TIA warrants further investigation.
Trends in phenotype in the English paediatric neurofibromatosis type 2 cohort stratified by genetic severity
Authors: Halliday Dorothy , Emmanouil Beatrice , Vassallo Grace , Lascelles Karine , Nicholson James , Chandratre Saleel , Anand Geetha , Wasik Martin , Pretorius Pieter , Evans D. Gareth , Parry Allyson ,   On behalf of the English NF2 research group
Published: April 2019

AbstractChildhood onset neurofibromatosis type 2 can be severe and genotype dependent. We present a retrospective phenotypic analysis of all ascertained children in England <age 18 (N = 87; male 61%). Mean age at last review was 13.9 years with mean follow‐up 6.5 years. Patients were stratified using a validated score (1A/1B:no NF2 pathogenic_variant in blood; 2A/2B:mild/moderate NF2 constitutional or mosaic pathogenic_variant in blood; 3: constitutional truncating exon 2‐13 pathogenic_variant. A total of 91% patients had a constitutional NF2 pathogenic_variant (44% de novo). Mean age at first manifestation was 4.3 and 8.8 years in groups 3 and 2A, respectively. Bilateral vestibular schwannoma, intracranial meningioma and spinal schwannoma occurred in 77%, 52% and 65% of group 3 patients, respectively, and 58%, 26% and 33% in 2A. A total of 43% group 3 and 18% 2A had severe unilateral visual loss (logmar >1.0). Focal cortical dysplasia occurred in 26% group 3 and 4% 2A. A total of 48% of group 3 underwent ≥1 major intervention (intracranial/spinal surgery/Bevacizumab/radiotherapy) compared to 35% of 2A; with 23% group 3 undergoing spinal surgery (schwannoma/ependymoma/meningioma resection) compared to 4% of 2A. Mean age starting Bevacizumab was 12.7 in group 3 and 14.9 years in 2A. In conclusion, group 3 phenotype manifests earlier with greater tumour load, poorer visual outcomes and more intervention.