bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Metabolic Screening Necessary in Children with Autism Spectrum Disorder? A Mini Review
Authors: Gogou Maria , Evangeliou Athanasios 
Published: December 2018

AbstractAutism spectrum disorder is a clinically heterogeneous entity with no known specific cause. A variety of inborn errors of metabolism include autistic-like phenotypes in their clinical manifestations. As targeted therapies for many of these errors exist, a question arises whether a routine metabolic screening in all children with autism should be performed. According to current literature, a metabolic workup should not be considered in children with nonsyndromic autism as a first-line investigation. However, detailed cost–benefit analyses are needed to investigate the benefit of a targeted screening of treatable metabolic errors compared with the total financial burden of autism.
Islamic customer relationship marketing (ICRM) and inspirations for religious tourism.
Authors: Kawsar M. J. , Rashid T. 
Published: December 2018

Abstract

The aim of this chapter is to explain and expand the understanding of Islamic customer relationship marketing (ICRM) and its factors for the purpose of religious tourism business. An extensive literature review of various business disciplines, including marketing, relationship marketing, customer relationship marketing, Islamic marketing, religious marketing and religious tourism, is presented in this chapter.
The impact of Umrah quality attributes on religious tourist loyalty in Saudi Arabia.
Authors: Ibrahim Alsini Ibrahim Alsini , Erdogan Ekiz Erdogan Ekiz , Kashif Hussain Kashif Hussain 
Published: December 2018

Abstract

The purpose of this chapter is to elaborate on how quality attributes for tourism activities are linked with tourist loyalty for a religious destination. The chapter reports findings of a research study that assessed Umrah quality attributes as presented in four dimensions (Islamic life and belief, Umrah package services, Umrah destination quality and religious tourist loyalty). These attributes are frequently used by researchers when investigating the quality of experience and loyalty and this chapter utilizes them to gauge religious tourists' perceptions after performing Umrah in Makkah, Saudi Arabia.
Religious tourism in the Sultanate of Oman: the potential for mosque tourism to thrive.
Authors: Kessler K. , Raj R. 
Published: December 2018

Abstract

The purpose of this chapter is to present religious tourism in the Sultanate of Oman and to determine the potential of mosque tourism as a means to contribute towards visitors' cultural experience enrichment. The chapter presents and discusses a classification of Oman's religious sites, including places of worship, tombs or graves of leading religious figures, sites where significant religious personalities lived or died, and sites commemorating specific religious events.
Battlefield tourism: the potential of Badr, Uhud and the Trench (Khandaq) battles for Islamic tourism.
Authors: Akbulut O. , Ekİn Y. 
Published: December 2018

Abstract

This chapter discusses the role of battlefield tourism within the context of Islamic tourism. Drawing insights from dark and heritage tourism literature, the chapter discusses why people are interested in visiting historical sites associated with famous battles. It then introduces three key battles in Saudi Arabia that have very high significance within the religion of Islam. The chapter finally discusses implications for Islamic tourism.
Tablighi Jamaat: a multidimensional movement of religious travellers.
Authors: Abbasi A. S. 
Published: December 2018

Abstract

Tablighi Jamaat is a voluntary mass movement that preaches Islamic teachings, mainly of the Deobandi school of thought, in the Indian subcontinent. This chapter aims to contribute to the religious tourism literature by discussing the transformative nature and role of Tablighi Jamaat within the context of Islamic tourism. To achieve this aim, the chapter provides a brief introduction to Tablighi Jamaat, briefly highlighting its history. It then provides an opportunity to the reader to understand the structure of this mass mobilization of human and other resources through religious travelling, the underlying principles and activities, mechanism of training and development of devotees, and the monitoring of performance and roles of both genders during practical involvements in activities of Tablighi Jamaat. In doing so, the chapter points to the significant transformative experiences that followers experience over an extended period of time. The implications of the movement for the Islamic tourism industry are also discussed, including its economic impact.
Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice
Authors: Watanabe Nana , Suzuki Takuya , Yamazaki Yuya , Sugiyama Kozue , Koike Seiji , Nishimukai Megumi 
Published: December 2018

ABSTRACT
Plasmalogen (Pls) is a glycerophospholipid derived from alkyl phospholipid (Alk) with antioxidant functions in vivo. The present study investigated the effects of ether phospholipids, such as Pls and Alk, on intercellular lipid barriers in the skin of NC/Nga mice, a model of atopic dermatitis (AD). NC/Nga mice fed Alk showed increased plasma levels of Alk and Pls. The AD-related changes in ceramide composition in the skin were abrogated by oral administration of Alk. Moreover, Alk suppressed skin inflammation in AD mice. These results indicate that Alk partially fortifies the stratum corneum lipid barrier and may be an effective treatment for AD.
Abbreviations: Pls: plasmalogen; PlsCho: choline plasmalogen; PlsEtn: ethanolamine plasmalogen; Alk: alkyl phospholipid; TJ: tight junction; FA: fatty acid; AD: atopic dermatitis; SO: soybean oil; FO: fish oil; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; TG: triglyceride; PL: phospholipid; RF: retention factor; AlkCho: choline-type alkyl phospholipid; AlkEtn: ethanolamine-type alkyl phospholipid; LC-MS/MS: liquid chromatography-tandem mass spectrometry; FAR1: fatty acyl-coenzyme (Co)A reductase 1
Attenuation and reflection measurements for coaxials at 100 MHz, 1 GHz and 10 GHz - Type N Connector (AFRIMETS.EM.RF-S1)
Authors: Magagula L , Mallat A , Fezai N , Sallam A R 
Published: December 2018

A supplementary comparison of two fixed attenuators (3 dB HP 8491B and 20 dB HP 8491B) for RF attenuation and two mismatched loads (Maury 2562C and Maury 2561A) for voltage reflection coefficient was carried out between three AFRIMETS members namely NMISA (South Africa, the pilot laboratory), DEFNAT (Tunisia) and NIS (Egypt). The motivation for the comparison was to verify the consistency and equivalence of RF attenuation and reflection measurements between the participants. The agreement between the participants' measurements was good as evidenced by the normalised error, which was less than unity for all the specified frequency points for both the attenuation measurements and voltage reflection coefficient measurements.
KEY WORDS FOR SEARCH
attenuation; measurement methods; reference value; reflection

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
How Did The American Recovery and Reinvestment Act Affect the Material Well‐Being of SNAP Participants? A Distributional Approach
Authors: Valizadeh Pourya , Smith Travis A 
Published: December 2018

AbstractMoney‐metric welfare, or material well‐being, can be defined by household expenditure. We find that the 2009 ARRA benefit increase improved material well‐being at all expenditure levels, which is interpreted as a first‐order policy improvement. The adverse effects of the 2013 benefit cuts, however, were concentrated among the most disadvantaged SNAP subpopulations. These effects are almost entirely driven by changes in food rather than nonfood spending. The asymmetric shift in the distribution of well‐being speaks to the resource management skills and coping strategies among the low‐income households, especially the most disadvantaged, and calls for improved education on budgeting skills.
Changes in physical and mental health are associated with cardiovascular disease incidence in postmenopausal women
Authors: Saquib Nazmus , Brunner Robert , Desai Manisha , Kroenke Candyce , Martin Lisa W , Daviglus Martha , Allen Norrina B , Robinson Jennifer , Tindle Hilary , Stefanick Marcia L 
Published: December 2018

Abstract

Background
physical and mental health are important risk factors for cardiovascular disease (CVD) incidence and death among postmenopausal women. The objective of this study was to assess whether changes in physical and mental health were associated with CVD incidence and death.

Methods
in the Women’s Health Initiative Observational Study, 48,906 women (50–79 years) had complete data at baseline on physical and mental health (assessed with Short Form-36) and key covariates. Changes in self-reported physical and mental health were calculated between baseline and year 3. Incident CVD and death between year 3 and end of the study were verified with medical records.

Results
over a median 8.2-year follow-up, 2,319 women developed CVD, and 1,571 women died, including 361 CVD deaths. Women with continued poor health and those with worsened health had significantly increased risk of CVD incidence, CVD-specific death and all-cause death relative to women with continued good health. Both major and minor declines in physical health were associated with an increased risk of these outcomes relative to women with no change in physical health. Only major declines in mental health were associated with poor prognosis.

Conclusions
changes in physical and mental health over 3 years were independently associated with subsequent CVD events.
Systematic characterization and prediction of post-translational modification cross-talk between proteins
Authors: Huang Rongting , Huang Yuanhua , Guo Yubin , Ji Shangwei , Lu Ming , Li Tingting 
Published: December 2018

Abstract

Motivation
Protein post-translational modifications (PTMs) regulate a wide range of cellular protein functions. Many PTM sites from the same (intra) or different (inter) proteins often cooperate with each other to perform a function, which is defined as PTM cross-talk. PTM cross-talk within proteins attracted great attentions in the past a few years. However, the inter-protein PTM cross-talk is largely under studied due to its large protein pair space and lack of a gold standard dataset, even though the PTM interplay between proteins is a key element in cell signaling and regulatory networks.

Results
In this study, 199 inter-protein PTM cross-talk pairs in 82 pairs of human proteins were collected from literature, which to our knowledge is the first effort in compiling such dataset. By comparing with background PTM pairs from the same protein pairs, we found that inter-protein cross-talk PTM pairs have higher sequence co-evolution at both PTM residue and motif levels. Also, we found that cross-talk PTMs have higher co-modification across multiple species and 88 human tissues or conditions. Furthermore, we showed that these features are predictive for PTM cross-talk between proteins, and applied a random forest model to integrate these features with achieving an area under the receiver operating characteristic curve of 0.81 in 10-fold cross-validation, prevailing over using any single feature alone. Therefore, this method would be a valuable tool to identify inter-protein PTM cross-talk at proteome-wide scale.

Availability and implementation
A web server for prioritization of both intra- and inter-protein PTM cross-talk candidates is at http://bioinfo.bjmu.edu.cn/ptm-x/. Python code for local computer is also freely available at https://github.com/huangyh09/PTM-X.

Supplementary information
Supplementary data are available at Bioinformatics online.
Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences
Authors: Rosenberg Noah A , Edge Michael D , Pritchard Jonathan K , Feldman Marcus W 
Published: December 2018

Abstract
Recent analyses of polygenic scores have opened new discussions concerning the genetic basis and evolutionary significance of differences among populations in distributions of phenotypes. Here, we highlight limitations in research on polygenic scores, polygenic adaptation and population differences. We show how genetic contributions to traits, as estimated by polygenic scores, combine with environmental contributions so that differences among populations in trait distributions need not reflect corresponding differences in genetic propensity. Under a null model in which phenotypes are selectively neutral, genetic propensity differences contributing to phenotypic differences among populations are predicted to be small. We illustrate this null hypothesis in relation to health disparities between African Americans and European Americans, discussing alternative hypotheses with selective and environmental effects. Close attention to the limitations of research on polygenic phenomena is important for the interpretation of their relationship to human population differences.
The Changing Relationship Between Partnership Status and Loneliness: Effects Related to Aging and Historical Time
Authors: Böger Anne , Huxhold Oliver 
Published: December 2018

Abstract

Objectives
Partnership status is a central predictor of loneliness. The strength of this predictive relationship, however, may decrease in the course of aging and over historical time. Moreover, there may be aging-related and historical changes in the satisfaction with partnership and singlehood.

Method
Longitudinal data from the German Ageing Survey (DEAS) assessed in 2008 and 2014 (N = 6,188, age range: 40–85 years) was analyzed with multigroup structural equation models to disentangle aging-related and historical changes in the relationship of partnership status and loneliness and in the average level of satisfaction with partnership and singlehood.

Results
With advancing age, partnership status became less predictive of loneliness and the satisfaction with being single increased. Among later-born cohorts, the association between partnership status and loneliness was less strong than among earlier-born cohorts. Later-born single people were more satisfied with being single than their earlier-born counterparts. There was no indication for an aging-related or historical decrease in partnership satisfaction.

Discussion
The relevance of partnership status as a predictor of social well-being is neither universal nor stable but appears to change in the course of aging and across historical time.
Sharing-Dominant Logic? Quantifying the Association between Consumer Intelligence and Choice of Social Access Modes
Authors: Aspara Jaakko , Wittkowski Kristina 
Published: December 2018

Abstract
With sharing economy and access-based consumption, consumers increasingly access goods through social access modes other than private ownership—such as co-ownership, leasing, or borrowing. Prior research focuses on consumers’ attitudinal motivations and consumption-cultural use experiences pertaining to such social exchange–based access modes. In so doing, prior research has overlooked the influence that consumers’ fundamental, even biologically shaped, cognitive traits may have on their choice of access modes. To fill this research gap, this study analyzes a data set of more than 30,000 new car registrations by male consumers in Finland, including cognitive test data from the Finnish Defense Forces and covariates from other governmental sources. The field data suggests that consumers’ intelligence scores and their choice to co-own and lease their cars are positively associated. Econometric evidence further suggests that the association between intelligence and choice of social exchange–based access modes can be explained by intelligent consumers’ higher social trust in people and institutions, as well as two circumstantial mechanisms: their financial standing and tendency to seek savings. The findings from the field data are supported by an additional survey study (n = 460). Implications for the evolution of markets and consumption, as well as human intelligence and cooperation, are discussed.
DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor
Authors: Schabla N Max , Mondal Koushik , Swanson Patrick C 
Published: December 2018

AbstractCullin-RING ligases (CRLs) comprise a large group of modular eukaryotic E3 ubiquitin ligases. Within this family, the CRL4 ligase (consisting of the Cullin4 [CUL4] scaffold protein, the Rbx1 RING finger domain protein, the DNA damage-binding protein 1 [DDB1], and one of many DDB1-associated substrate receptor proteins) has been intensively studied in recent years due to its involvement in regulating various cellular processes, its role in cancer development and progression, and its subversion by viral accessory proteins. Initially discovered as a target for hijacking by the human immunodeficiency virus accessory protein r, the normal targets and function of the CRL4 substrate receptor protein DDB1–Cul4-associated factor 1 (DCAF1; also known as VprBP) had remained elusive, but newer studies have begun to shed light on these questions. Here, we review recent progress in understanding the diverse physiological roles of this DCAF1 in supporting various general and cell type-specific cellular processes in its context with the CRL4 E3 ligase, as well as another HECT-type E3 ligase with which DCAF1 also associates, called EDD/UBR5. We also discuss emerging questions and areas of future study to uncover the dynamic roles of DCAF1 in normal physiology.
The Utility and Construct Validity of Four Measures of Pain Intensity: Results from a University-Based Study in Spain
Authors: Jensen Mark P , Castarlenas Elena , Roy Rubén , Tomé Pires Catarina , Racine Mélanie , Pathak Anupa , Miró Jordi 
Published: December 2018

Abstract

Objective
Pain intensity is the most commonly assessed domain in pain research and clinical settings. To facilitate cross-cultural research, knowledge regarding the psychometric properties of pain intensity measures in individuals from different countries is needed. However, the majority of this research has been conducted in English-speaking countries.

Design
Survey study.

Setting
University.

Subjects
Four hundred nineteen college students.

Methods
Participants were asked to complete four measures assessing average pain intensity: 1) the 0–10 numerical rating scale (NRS-11), 2) the 100-mm visual analog scale (VAS), 3) the four-point verbal rating scale (VRS-4), and 4) the Faces Pain Scale–Revised (FPS-R).

Results
The rates of incorrect completion of the four scales were uniformly low (range = 1–2%). The NRS-11 had the highest preference rate (31%), although a substantial number of participants also preferred each of the other three scales (range = 22–24%). The findings support the utility and construct validity of all four pain intensity scales in this Spanish-speaking sample.

Conclusions
When considered in light of research from other non-English-speaking samples indicating significant psychometric weaknesses for the NRS-11 and VAS and relative strengths of the FPS-R in some groups, the findings suggest that the FPS-R might be the most appropriate pain intensity scale to use when comparisons across populations from different countries is a goal. More research is needed to determine the extent to which demographic (i.e., age, education levels, socioeconomic status) vs cultural factors (i.e., country of origin) influence the reliability, validity, and utility of different pain measures.
Developmental Trajectories and Reference Percentiles for Range of Motion, Endurance, and Muscle Strength of Children With Cerebral Palsy
Authors: Jeffries Lynn M , LaForme Fiss Alyssa , Westcott McCoy Sarah , Bartlett Doreen , Avery Lisa , Hanna Steven ,   On Track Study Team
Published: December 2018

AbstractBackgroundChildren with cerebral palsy (CP) frequently present with secondary impairments in spinal alignment and extremity range of motion, endurance for activity, and muscle strength. Creation of developmental trajectories for these impairments will help guide clinical decision-making.ObjectiveFor children in each level of the Gross Motor Function Classification System (GMFCS) this study aimed to: (1) create longitudinal developmental trajectories for range of motion (Spinal Alignment and Range of Motion Measures [SAROMM]), endurance (Early Activity Scale for Endurance [EASE]), and functional strength (Functional Strength Assessment [FSA]); and (2) develop age-specific reference percentiles and amount of change typical over 1 year for these outcomes.DesignThis study used a longitudinal cohort design.MethodsParticipants comprised 708 children with CP across GMFCS levels, aged 18 months up to the 12th birthday, and their families. In 2 to 5 assessments every 6 months over 2 years, trained therapists performed the SAROMM and FSA, and parents completed the EASE questionnaire. For children in each GMFCS level, longitudinal trajectories using linear and nonlinear mixed-effects models from all visits, and reference percentiles using quantile regression from the first, 12-month, and 24-month visits were created for each measure.ResultsLongitudinal trajectories and percentile graphs for SAROMM, FSA, and EASE were primarily linear, with different performance scores among GMFCS levels. There was much variability in both longitudinal trajectories and percentiles within GMFCS levels.LimitationsLimitations included a convenience sample and varying numbers of participants assessed at each visit.ConclusionsThe longitudinal trajectories and percentile graphs have application for monitoring how children with CP are performing and changing over time compared with other children with CP. The resources presented allow therapists and families to collaboratively make decisions about intervention activities targeted to children's unique needs.
Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II)
Authors: Chinchilla Sandra P , Doherty Michael , Abhishek Abhishek 
Published: December 2018

Abstract

Objectives
To examine the predictive validity of the Gout Activity Score (GAS), its correlation with the Gout Impact Scale (GIS) and their sensitivity to change.

Methods
Data from a clinical trial in which participants with one or more gout flares in the previous year were recruited from primary care and randomized to nurse-led or continuing usual care were used in this study. GAS and GIS were calculated as described, with higher scores indicating worse disease activity and quality of life, respectively. The correlation between GAS and GIS was examined using Spearman’s correlation. Standardized response means (SRMs) were calculated to assess sensitivity to change. The association between GAS at baseline and the number of flares in the next 12 months was evaluated using Poisson regression. Data analyses were performed using STATA version 14, with P-values <0.05 being statistically significant.

Results
There was low positive correlation between GAS and gout concern overall and unmet treatment need subscales of GIS (r = 0.34–0.45). Female sex associated independently with fewer gout flares, while increasing GAS, BMI and age associated independently with frequent flares. Of all the outcome measures examined, GAS was the most responsive to change (SRM 0.89 to −0.53). Of the GIS domains, the gout concern overall domain had the best sensitivity to change (SRM 1.06–0.01).

Conclusion
GAS is sensitive to change, has predictive validity and correlates with relevant domains of GIS such as gout concern overall. Additional independent validation of GAS is required before it can be adopted in clinical practice.