bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Prognostic Role of Immune System Activation Marker Neopterin in Patients with Type 2 Diabetes
Authors: Ünüvar Songül , Tanrıverdi Zübeyde , Aslanhan Hamza 
Published: May 2018

Summary
Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-γ) activation. These include viral and bacterial infections, auto immune diseases, metabolic diseases, psychiatric disorders, tissue and organ rejections, and different malignancies. The aim of this study was to evaluate the role of neopterin as a prognostic biomarker in type 2 diabetes, which is a metabolic disease with a high worldwide prevalence.
Methods: The study included a total of one hundred thirtynine individuals including one hundred and six patients admitted to a family medicine outpatient clinic and diagnosed with type 2 diabetes and thirty-three healthy volunteers. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay.
Results: Serum neopterin levels significantly increased in type 2 diabetes patients, compared to the control group (p<0.001).
Conclusions: Early diagnosis of diabetes and determination of the appropriate therapeutic options are of utmost importance, as diabetes is also associated with other systemic diseases. The risk of developing secondary diseases is high in untreated patients. Our study results suggest that serum neopterin may be a useful biomarker in patients with type 2 diabetes.
Profiles of Circulating miRNAs Following Metformin Treatment in Patients with Type 2 Diabetes
Authors: Demirsoy İbrahim Halil , Ertural Duygu Yolal , Balci Şenay , Çınkır Ümit , Sezer Kerem , Tamer Lülüfer , Aras Nurcan 
Published: May 2018

Summary
Background: Metformin, a widely used biguanide class of anti-diabetic drug, has potential to increase insulin sensitivity and reduce blood glucose to treat type 2 diabetes (T2D). It has been reported that metformin has an activity on regulation of miRNAs by targeting several downstream genes in metabolic pathways. However, molecular mechanism underlying the process is still not fully known. In this study, it was aimed to identify differential expression profiles of plasma derived miRNAs following 3 months metformin treatment in patients with T2D.
Methods: The plasma samples of 47 patients with T2D (received no anti-diabetic treatments) and plasma samples of same 47 patients received 3 months metformin treatment was recruited to the study. Total RNAs were isolated from plasma and reverse transcribed into cDNA. Profiles of differential expressions of miRNAs in plasma were assessed by using of micro-fluidic based multiplex quantitative real time -PCR (BioMarkTM 96.96 Dynamic Array).
Results: Our results showed that expression profiles of 13 candidate miRNAs; hsa-let-7e-5p, hsa-let-7f-5p, hsa-miR- 21-5p, hsa-miR-24-3p, hsa-miR-26b-5p, hsa-miR-126-5p, hsa-miR-129-5p, hsa-miR-130b-3p, hsa-miR-146a-5p, hsamiR- 148a-3p, hsa-miR-152-3p, hsa-miR-194-5p, hsa-miR- 99a-5p were found significantly downregulated following metformin treatments in patients with T2D (p<0.05).
Conclusions: In conclusion, our finding could provide development of better and more effective miRNAs based therapeutic strategies against T2D.
Novel Mutations in Serbian MEN1 Patients: Genotype-Phenotype Correlation
Authors: Isailovic Tatjana , Milicevic Ivana , Macut Djuro , Petakov Milan , Ognjanovic Sanja , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Kovacevic Valentina Elezovic , Ilic Dusan , Damjanovic Svetozar 
Published: May 2018

Summary
Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome characterized by the occurrence of primary hyperparathyroidism (PHPT), pituitary adenoma (PA) and pancreatic neuroendocrine tumor (pNET). Whether the underlying mutations in MEN1 gene predict clinical presentation of affected heterozygotes or not, is still a matter of a debate.
Methods: Clinical and genetic analysis of 90 consecutive MEN1 patients was performed in a retrospective, single – center study.
Results: MEN1 mutation was found in 67 (74.4%) patients belonging to 31 different families. Twenty nine different heteozygous mutations were found, including 6 novel point mutations (W220G, 941delG, 1088del7, 1184insA, 1473del10, 1602del17) and one large deletion of exon 8. Truncating mutations predicted development of pNETs (OR=5.8, 95% CI 1.7 – 19.7%) and PHPT (OR=4.3, 95% CI 1.5 – 12.4%).
Conclusions: Large number of novel mutations among MEN1 patients confirmed previously reported data. PNETs and PHPT were more frequent in patients with truncating mutations.
Significance of UGT1A1*28 Genotype in Patients with Advanced Liver Injury Caused by Chronic Hepatitis C
Authors: Jordovic Jelena , Bojovic Ksenija , Simonovic-Babic Jasmina , Gasic Vladimir , Kotur Nikola , Zukic Branka , Vukovic Marija , Pavlovic Sonja , Lazarevic Ivana , Bekic Ivana , Nikolic Natasa , Uroševic Aleksandar , Mitrovic Nikola , Delic Dragan 
Published: May 2018

SummaryBackground:Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations inUGT1A1gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association ofUGT1A1TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse.Methods:Genetic testing ofUGT1A1TA repeats promoter genotypes was performed in 42 CHC patients with advanced fibrosis and cirrhosis who achieved sustained virological response and 42 healthy blood donors. CHC patients were evaluated for clinical findings, laboratory tests and imaging.Results:UGT1A1*28 genotype (7/7 TA repeats) was observed in 23.8% CHC patients and 16.7% healthy controls with no significant difference in genotype frequencies (p=0.49). Pretreatment levels of ferritin and bilirubin were associated with the presence ofUGT1A1*28genotype, indicating its potential as a predictive marker. However, in our study, there was no correlation ofUGT1A1*28genotype with the degree of fibrosis or viremia. During antiviral treatment, dose reductions and treatment interruptions, as well as treatment success and occurrence of late virological relapse were not related to the presence ofUGT1A1*28genotype in CHC patients with severe liver injury.Conclusions:Frequencies ofUGT1A1*28genotype are high in both Serbian CHC patients and healthy subjects. The presence ofUGT1A1*28genotype was not associated with ribavirin-related adverse effects and had no effect on long term outcome in CHC patients.
Status of the eastern imperial eagle (Aquila heliaca) in the Czech Republic – 2013 update, ringing results and new findings
Authors: Horal David 
Published: May 2018

Abstract
Although unconfirmed reports on the breeding of the eastern imperial eagle exist from as early as in 1 920s, the first confirmed breeding only took place in 1 998. Since then, 1-5 pairs have bred annually, chiefly in the South Moravia region (the Breclav, Znojmo and the Brno-venkov districts). Out of 37 breeding attempts, 26 (i.e. 70%) were successful, with 48 young reared. The paper summarizes some characteristics of the breeding biology (productivity, breeding losses, nesting tree species, nest height, nest turnover, minimum convex polygon of the nests [nesting trees] built by individual pairs) as well as ringing recoveries. Out of 42 ringed chicks, 39 fledged successfully and produced 3 recoveries (Slovakia - 2, Austria - 1 ). Three foreign ringed birds were also sighted in the Czech Republic. The most interesting case is the breeding of a 1 9-year-old female born in eastern Slovakia (distance 336 km), found via a photo of the ring (V. Gahura, 201 3).
PENERAPAN MODEL PROJECT BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN MENULIS SISWA
Authors: Anggara Syamfa Agny 
Published: May 2018

The learning process has a close relationship with the influential elements that such as approaches, methods, and techniques. The purpose of this study is to describe objectively, (a) the application of writing learning using project-based learning model in the learning of Arabic in grade VII Madrasah Tsanawiyah Nurul Huda Malang, (b) the result of improving the writing ability of Arabic language by applying project based learning model to the students class VII Madrasah Tsanawiyah Nurul Huda Malang. This study used a classroom action plan. The results showed that the application of Arabic language learning with project-based learning model can improve the writing skills of grade VII of Madrasah Tsanawiyah Nurul Huda Malang.
Penerapan Algoritma Fuzzy C Means untuk Analisis Permasalahan Simpanan Wajib Anggota Koperasi
Authors: Rustiyan Risma , Mustakim Mustakim 
Published: May 2018

Koperasi mempunyai peranan penting bagi perekonomian Indonesia. Perkembangan koperasi di Indonesia saat ini cukup pesat, pada data Badan Pusat Stastitik 3 tahun terakhir yang di-update pada tanggal 20 Juni 2016 sementara menyebutkan jumlah koperasi aktif di Indonesia pada tahun 2015 sebanyak 150.223. Pusat Koperasi Unit Desa (PUSKUD) Provinsi Riau merupakan salah satu jenis koperasi sekunder dalam bidang pertanian. Koperasi ini menjadi salah satu penunjang perekonomian rakyat. Proses yang berjalan antara PUSKUD dan anggota adalah pengelolaan sisa hasil usaha (SHU) dan dalam permodalan. Permasalahan yang terjadi adalah partisipasi aktif dari anggota koperasi untuk menunaikan kewajiban masih kurang dari yang diharapkan. Untuk membantu mengatasi permasalahan tersebut, perlu dibentuk suatu pengelompokan Anggota PUSKUD berdasarkan Kabupaten/ Kota domisili dalam pembayaran Simpanan Wajib. Metode yang digunakan adalah Data Mining Clustering dengan algoritma Fuzzy C Means. Dari hasil pengklusteran, pada tahap akhir analisis diketahui, Terdapat 75 anggota yang tersebar pada wilayah Kabupaten/ Kota Rokan Hulu, Kampar, Indragiri Hulu dan Indragiri Hilir serta terdaftar pada tahun 80-an yang perlu untuk ditinjau kembali. Hasil Pengujian Nilai Validitas PC, didapatkan sebesar 0,323732, dengan demikian kualitas Cluster masih jauh untuk mencapai kata optimal. Kata kunci: Clustering, Data Mining, Fuzzy C Means, Koperasi, Simpanan Wajib, Partition Coefficient Abstract Cooperatives have an important role for the Indonesian economy. The development of cooperatives in Indonesia is currently quite rapid, On the data from Badan Pusat Statistik (BPS) of the last 3 years updated on June 20, 2016 While mentioning the number of active cooperatives in Indonesia in 2015 as much as 150,223. Pusat Koperasi Unit Desa (PUSKUD) Provinsi Riau is one of the secondary cooperative in agriculture. This cooperative became one of the supporting people's economy. The process that runs between PUSKUD dan members is the management of the remaining results of the business and the capital. The problem that occurs is the use of members of the cooperative to fulfill the obligations is still less than expected. To help overcome these problems, it is necessary to form a grouping of PUSKUD Members by Regency / City domicile in the payment of Mandatory Deposits. The method used is Data Mining Clustering with Fuzzy C Means algorithm. From the results of the clustering, at the final stage of the analysis is known, There are 75 members scattered in the District / City of Rokan Hulu, Kampar, Indragiri Hulu dan Indragiri Hilir dan registered in the 80s that need to be reviewed. Test Result Validity Value of Partition Coefficient, obtained for 0,323732, thus the quality of Cluster is still far to achieve optimal. Keywords: Clustering, Cooperative, Data Mining, Fuzzy C Means, Mandatory Deposit, Partition Coefficient
Perancangan Sistem Pendukung Keputusan Untuk Prediksi Penerima Beasiswa Menggunakan Metode Neural Network Backpropagation
Authors: Pujianto Ade , Kusrini Kusrini , Sunyoto Andi 
Published: May 2018

Seleksi di Amikom masih mengalami kendala pada proses pengambilan keputusan, banyaknya data menyebabkan pengambil keputusan membutuhkan tools yang dapat membantu dalam menentukan penerima beasiswa, salah satu metode yang sering digunakan adalah artificial neural network (ANN). Metode ini meniru jaringan pemodelan saraf otak manusia berupa neuron-neuron untuk menyelesaikan suatu permasalahan. Salah satu penerapan neural network adalah untuk melakukan prediksi atau peramalan terhadap suatu peristiwa tertentu serta dianggap mampu menyelesaikan masalah yang komplek seperti penalaran otak manusia. Untuk menyelesaiakn masalah yang komplek neural network memerlukan banyak neuron atau yang biasa disebut layer (lapis). Salah satu metode neural network multi lapis adalah backpropagation yang mampu mengoptimalisasi bobot pada neuron dan menyelesaikan masalah yang komplek. Hasil dari penelitian ini adalah sebuah perancangan sistem prediksi dengan menggunakan metode neural network backpropagation untuk melakukan peramalan terhadap mahasiswa yang mendaftar beasiswa. hasil akhir penelitian ini adalah nilai akurasi sebesar 90% dan nilai error terkecil sebesar 0,000101 pada epoch ke 329 dengan jumlah 3000 data dengan pembagian data training 2.250 dan 750 data testing serta konfigurasi learning rate sebesar 0,2 dan momentum 0,2. Kata kunci: Artificial Neural netwok, Backpropagarion, Prediksi, beasiswa, Pengambilan Keputusan. AbstractSelection in Amikom is still constrained in the decision-making process, the number of data causing decision makers need tools that can assist in determining scholarship recipients, one of the most commonly used method is artificial neural network (ANN). This method mimics the neural network modeling of the human brain in the form of neurons to solve a problem. One application of neural network is to make predictions or forecasting of a particular event and is considered capable of solving complex problems such as human brain reasoning. To solve the problem the complex neural network requires many neurons or so-called layers. One method of multi layer neural network is backpropagation that is able to optimize the weight of neurons and solve complex problems. The result of this research is a prediction system design using neural network backpropagation method to forecast the students who apply for scholarship. the final result of this research is the accuracy value of 90% and the smallest error value of 0.000101 on epoch to 329 with the amount of 3000 data with sharing training 2,250 and 750 data testing and learning rate configuration of 0.2 and momentum 0.2.Keywords: Artificial Neural Netwok, Backpropagarion, Prediction, Scholarship, Decision Making.
ANALISIS KINERJA KEUANGAN KEMENTERIAN KELAUTAN DAN PERIKANAN REPUBLIK INDONESIA TAHUN 2014 – 2016
Authors: Indriyani Indriyani , Pandansari Tiara 
Published: May 2018

Penelitian ini bertujuan untuk menganalisis kinerja keuangan Kementerian Kelautan dan Perikanan Republik Indonesia.Periode pengamatan dalam penelitian ini adalah 2014-2016.Data yang digunakan dalam penelitian ini berupa data sekunder yaitu laporan keuangan Kementerian Kelautan dan Perikanan Republik Indonesia.Metode penelitian yang dilakukan adalah metode deskriptif kuantitatif.Hasil penelitian ini menunjukkan bahwa pada Kementerian Kelautan dan Perikanan terjadi fluktuasi kinerja keuangan dilihat dari rasio likuiditas, solvabilitas, efisiensi, dan pertumbuhan.Jika disorot dari keseluruhan rasio, dapat disimpulkan bahwa Kementerian Kelautan dan Perikanan secara kelancaran keuangan dan kemandirian keuangn dapat dikatakan baik, akan tetapi, jika dilihat dari tingkat pengelolaan keuangan yang dilihat dari rasio pertumbuhan pendapatan dan belanja serta efisiensi dapat dikatakan kurang baik
Implications of global peak population for Canada’s future: Northern, rural, and remote communities
Authors: Cooke Martin 
Published: May 2018

The broad demographic changes that are affecting the Canadian population, including population aging and changes to immigration, will not have the same impact or implications in all places across the country. For communities in the North and rural and remote communities in the South, the patterns of demographic change might be quite different from those faced by cities. There is also considerable diversity among these non-urban areas. Non-urban hinterlands that are within commuting distance of cities (high Metropolitan Influence) have been growing, with some being reclassified as parts of urban agglomerations. Population change in rural areas that are outside of urban influence is more closely related to employment dynamics in particular sectors, especially agriculture and resource extraction. Populations of many of those communities have been declining and aging due to out-migration of young adults and a lack of immigration. In the North, where populations are younger, resource development has meant rapid change to Northern communities and cultures. Current challenges for Northern, rural and remote communities include potential labour force skills shortages and adapting infrastructure to a changing population, in the context of difficult geography. Future issues related to population change have implications for social cohesion. In the North, there is a risk of widening socioeconomic inequality, particularly between Indigenous and non-Indigenous populations. In the South, disparities in lifestyles and labour force experiences between rural and urban populations might also grow. Recommendations for knowledge development include more research on the effective recruitment and retention of professionals, including immigrants, in these areas, as well as better sources of data on Northern populations.
The well-being of families in Canada’s future
Authors: Laplante Benoît 
Published: May 2018

The author argues that the well-being of families in Canada’s future is uncertain because families are losing the central position that was traditionally theirs. Most of the changes that occurred in and around families over the last third of the 20th century came from changes in values (from survival to personal development, from collectivity-oriented to individual-oriented), in gender relations (rising education, labour force participation, and economic independence of women), and in the legal framework that deals with family life. Such changes are still having an impact on families and this impact will likely not diminish. But more than anything else, Canadian society is moving towards a model in which immigration rather than reproduction is the main source of population growth, thus reducing the importance of the family for the development of policies. This, and the increasing political importance given to environmental issues, might further displace the family as a priority for policymaking and the allocation of public resources, and thus impair the future well-being of families.L’auteur soutient que le bien-être des familles canadiennes des familles est loin d’être assuré à long terme parce que la famille, en tant qu’institution, perd aujourd’hui la position centrale qui était traditionnellement la sienne. La plupart des changements survenus dans et autour des familles au cours du dernier tiers du XX e siècle ont été la conséquence de changements dans les valeurs (de la primauté de la survie à celle du développement personnel, de la collectivité à l’individu), dans les rapports entre les sexes (l’éducation des femmes, leur activité et leur indépendance économique) et dans l’encadrement juridique de la vie familiale. Ces transformations se poursuivent et leur impact sur les familles ne diminuera probablement pas. À ceci s’ajoute le fait que la société canadienne a adopté un modèle où l’immigration remplace la reproduction comme source principale de la croissance démographique, réduisant encore plus l’importance de la famille pour l’élaboration des politiques. Ce changement, et l’importance croissante accordée aux questions environnementales, pourrait encore réduire la place de la famille en tant que priorité pour l’élaboration des politiques et l’allocation des ressources publiques, et ainsi compromettre le bien-être futur des familles.
Kejadian Menggigil Pasien Pasca Seksio Sesarea dengan Anestesi Spinal yang Ditambahkan Klonidin 30 mcg Intratekal di RSUD Arifin Achmad Pekanbaru, Indonesia
Authors: Irawan Dino 
Published: May 2018

Menggigil pasca anestesia merupakan mekanisme kompensasi tubuh yang dapat menimbulkan efek samping antara lain pasien merasa tidak nyaman bahkan nyeri hingga dapat meningkatkan kebutuhan oksigen karena adanya peningkatan aktifitas otot. Menggigil pasca anestesi pada pasien yang menjalani seksio sesarea yang dilaporkan berkisar antara 37-57%. Kejadian tersebut dapat diatasi dengan beberapa cara salah satunya dengan pendekatan farmakologis. Klonidin merupakan parsial agonis α2adrenergik yang secara ekstensif dievaluasi sebagai adjuvan anestesi spinal dan memiliki efek anti menggigil. Penelitian ini bertujuan untuk mengetahui prevalensi kejadian menggigil, karakteristik menggigil, dan perubahan tanda vital pasien seksio sesarea pasca anestesi spinal yang diberikan klonidin 30 mcg intratekal. Penelitian ini bersifat deskriptif. Observasi dilakukan di ruang pemulihan RSUD Arifin Achmad Pekanbaru dengan jumlah sampel sebanyak 30 pasien. Hasil penelitian menunjukkan 5 dari 30 pasien (16,7%) mengalami kejadian menggigil. Berdasarkan derajat menggigil, 25 pasien (83,3%) derajat 0, dan 5 pasien derajat 1 (16,7%). Pada penelitian ini perubahan suhu tubuh, tekanan darah, dan denyut nadi hanya terjadi sedikit perubahan.
Analisis Kinerja Keuangan Perusahaan dengan Metode Economic Value Added (EVA) (Studi Kasus Perusahaan Otomotif Go Publik)
Authors: Mubarok Rahman , Dewi Farida Ratna 
Published: May 2018

Global economics crisis causes the fall of world stock. This is causes weakens it share in BEI, including sector otomotif. BEI has some stock indexes as movement indicator of stock price, one of them is index Kompas 100. This Index represents of about 70-80 percent market capitalization value total of share in BEI. However, that can be different with other index, so that be necessary to measure of each corporate performance with using Economic Value Added (EVA) method. EVA is used to measure of corporate performance based of the value. value added will be create, if the retained earning more than cost of capital. From two company analized during the 2007 to 2008 period, there is only one of corporate have a performance increase at 2008, that is PT Multistrada Arah Sarana Tbk, this is mean the corporate has been investor expectation filled. Differ from PT Multistrada, PT Gajah Tunggal at 2008 have a performance decrease. At 2007 it have positive value of EVA, but at 2008 value of EVA get down to negative. This is happen cause of dead loss in consequence of global economics crisis. For the companies that give the negative value, it better find out more strategies so it can make their profit rise and also to push the capital cost with choosing the lowest capital structure. Beside that, the companies also should erase the activities that can caused the value of the company becoming less.