bluuebunny/crossref_metadata_2025_split huggingface dataset:
High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments
Authors: Hu Jiliang , Li Yiwei , Hao Yukun , Zheng Tianqi , Gupta Satish K. , Parada German Alberto , Wu Huayin , Lin Shaoting , Wang Shida , Zhao Xuanhe , Goldman Robert D. , Cai Shengqiang , Guo Ming 
Published: August 2019

Significance
Intermediate filaments (IFs) remain the least understood with respect to their functions in mammalian cells even though they have been related to many devastating human diseases. Here we use optical tweezers to perform micromechanical measurements in living cells and in IF enriched cytoskeletons devoid of actin and microtubules. We identify that cytoskeletal vimentin IFs (VIFs) provide cells with a hyperelastic rubber-like network that regulates the essential mechanical properties of mammalian cells including stretchability, strength, resilience, and toughness. We show that VIFs maintain cell integrity and viability under conditions involving extreme deformations. We further show that the stretchy VIF network can effectively disperse locally induced mechanical stress to larger regions within individual cells, enabling the dissipation of energy throughout a cell.
Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage
Authors: Vulliamy Paul , Gillespie Scarlett , Armstrong Paul C. , Allan Harriet E. , Warner Timothy D. , Brohi Karim 
Published: August 2019

Significance
Membrane ballooning is a fundamental mechanism by which platelets contribute to thrombin generation. However, this process has not previously been described in human disease. In this study, we demonstrated the presence of ballooning procoagulant platelets free in the circulation of critically injured humans, a phenomenon which results in systemic generation of thrombin and contributes to an acute coagulopathy. The surfaces of ballooning platelets were decorated with the damage-associated molecular pattern histone H4, and exposure of healthy platelets to histone caused membrane disruption and recapitulated the phenotypic changes in injured patients. These findings provide a description of platelet ballooning contributing to human disease and identify histone release from injured tissues as a driver of the procoagulant ballooning process.
Mapping the effects of drought on child stunting
Authors: Cooper Matthew W. , Brown Molly E. , Hochrainer-Stigler Stefan , Pflug Georg , McCallum Ian , Fritz Steffen , Silva Julie , Zvoleff Alexander 
Published: August 2019

Significance
We use geolocated child nutrition data from 53 developing countries to show that minor to severe droughts as well as severe periods of extreme rainfall are related to child stunting. We then explore how various geographic factors mitigate or amplify the effect of drought on child heights. Finally, we combine global data on these factors to map where child stunting is currently vulnerable to drought, finding that arid low-income countries with poor governance and political instability are where drought could have the largest effect on child stunting.
Complex dynamics under tension in a high-efficiency frameshift stimulatory structure
Authors: Halma Matthew T. J. , Ritchie Dustin B. , Cappellano Tonia R. , Neupane Krishna , Woodside Michael T. 
Published: August 2019

Significance
Programmed ribosomal frameshifting (PRF) is important to many viruses, but how structures in mRNA stimulate PRF remains uncertain. By studying a frameshift signal stimulating very high PRF in West Nile virus (WNV), we identify features that differ from other structures stimulating more modest PRF levels. Using single-molecule force spectroscopy to mimic the effects of tension applied to the RNA by the ribosome during translation, we find that the WNV frameshift signal exhibits exceptionally heterogeneous conformational dynamics, forming several different pseudoknots and multiple combinations of hairpins, all connected on 2 mutually exclusive pathways. This work supports a role for conformational heterogeneity in PRF, suggesting that dynamic fluctuations rather than static properties play a key role in stimulating PRF efficiently.
Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha
Authors: Alam Camille , Aufreiter Susanne , Georgiou Constantine J. , Hoque Md. Tozammel , Finnell Richard H. , O’Connor Deborah L. , Goldman I. David , Bendayan Reina 
Published: August 2019

SignificanceFolates are critical for brain development and function. Abnormalities in brain folate transport have been implicated in a number of childhood neurodevelopmental disorders, including cerebral folate deficiency syndrome, hereditary folate malabsorption, and autism spectrum disorders. These disorders have devastating effects in young children, and current therapeutic approaches are not sufficiently effective. In this study, we demonstrate that functional expression of the folate transporter, reduced folate carrier, at the blood–brain barrier and its upregulation by the vitamin D nuclear receptor can remarkably increase folate transport to the brain. These findings provide a strategy for enhancing brain folate delivery for the treatment of neurometabolic disorders caused by folate transport defects.
Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity
Authors: Pant Vinod , Xiong Shunbin , Wasylishen Amanda R. , Larsson Connie A. , Aryal Neeraj K. , Chau Gilda , Tailor Ramesh C. , Lozano Guillermina 
Published: August 2019

Significance
Gastrointestinal (GI) failure is a serious dose-limiting side effect observed in patients undergoing lower-abdominal radiotherapy with no approved protective measure/cure. Here, we show that increased p53-induced p21 activity protects against radiation-induced GI toxicity in a genetically engineered mouse model. This radioprotection can be recapitulated in wild-type mice by pretreating them with RG7112, a pharmacological compound that enhances p53 activity by disrupting p53–Mdm2 interaction. These results signify that transient enhancement of wild-type p53 activity by pharmacological means could be exploited as a potential prophylactic strategy to alleviate GI toxicity issues in patients undergoing radiotherapy in the clinic.
Learning active sensing strategies using a sensory brain–machine interface
Authors: Richardson Andrew G. , Ghenbot Yohannes , Liu Xilin , Hao Han , Rinehart Cole , DeLuccia Sam , Torres Maldonado Solymar , Boyek Gregory , Zhang Milin , Aflatouni Firooz , Van der Spiegel Jan , Lucas Timothy H. 
Published: August 2019

Significance
Our sensory experience is governed by sensor properties (e.g., eye photoreceptors) and corresponding motor strategies to sample the environment (e.g., eye movements). With injury, aging, or new task constraints, existing strategies can become incompatible with perceptual demands. Using a brain–machine interface paradigm in rats, we studied how motor strategies are adapted to new sensory inputs to accomplish a difficult searching task. We show that the strategies can be dynamically regulated through experience to optimally extract task-relevant sensory information.
Generalised versions of separable decompositions applicable to bipartite entangled quantum states
Authors: Anwar Hussain , Jevtic Sania , Rudolph Oliver , Virmani Shashank 
Published: August 2019

Abstract
The investigation of separable states in quantum theory has been driven by the notion that they are highly classical, in that they do not demonstrate nonlocality, and are in some contexts unable to support non-classical computation. The converse question, the extent to which entangled states do or do not support non-classical information processing, is less well understood. Motivated by this question we extend the notion of quantum separability into the entangled quantum states, by constructing separable decompositions that describe them with the ‘smallest’ possible sets of non-physical local operators. We consider a few ways to define the word ‘smallest’ and present techniques for obtaining them. The methods involve calculating certain forms of cross norm. The results generalise significantly the results obtained in our previous work on this topic (2015 New J. Phys. 17 093047), and can be be used to construct classical simulation methods and local hidden variable models for subsets of local measurements on entangled quantum states.
Anisotropy in condensed matter — liquid crystals, glass, and phase coexistence
Authors: Aoki K M 
Published: August 2019

Abstract
Molecular dynamics (MD) methods suitable for treating anisotropic fluctuations in condensed matter are discussed. Barostats with two anisotropic factors to control the simulation cell dynamics are introduced in three MD simulation methods; constant pressure, constant surface tension, and canonical hydrostatic. To demonstrate the possibilities of these methods, calculations of two systems, one consisting of anisotropic particles and other consisting of isotropic particles, are presented.
Thermodynamic analysis of semiflexible helical polymers
Authors: Williams Matthew J. , Bachmann Michael 
Published: August 2019

Abstract
Tertiary structure formation underlies the folding mechanics of many classes of polymers. A simplified model of helical polymers is a useful system in which to begin studying the formation and properties of compact conformations known from biomolecules. Hyper-phase diagrams and structural transitions are presented for polymers of length 40 and 50 over an array of model parameters.
Ab initio density-functional studies of 13-atom Cu and Ag clusters
Authors: Limbu Dil K. , Madueke Michael U. , Atta-Fynn Raymond , Drabold David A. , Biswas Parthapratim 
Published: August 2019

Abstract
The putative ground-state structures of 13-atom Cu and Ag clusters have been studied using ab initio molecular-dynamics (AIMD) based on density-functional theory (DFT). An ensemble of low-energy configurations, collected along the AIMD trajectory and optimized to nearest local minimum-energy configurations, were studied. An analysis of the results suggests the existence of low-symmetric bilayer structures as strong candidates for the putative ground-state structure of Cu13 and Ag13 clusters. These bilayer structures are markedly different from a buckled bi-planar (BBP) configuration and energetically favorable, by about 0.4–0.5 eV, than the latter proposed earlier by others. Our study reveals that the structure of the resulting putative global-minimum configuration is essentially independent of the nature of basis functions (i.e., plane waves vs. pseudoatomic orbitals) employed in the calculations, for a given exchange-correlation functional. The structural configurations obtained from plane-wave-based DFT calculations show a noticeably tighter or dense first-shell of Cu and Ag atoms. A comparison of our results with recent full-potential DFT simulations is presented.
On properties of the Wang–Landau algorithm
Authors: Shchur L. N. 
Published: August 2019

Abstract
We review recent advances in the analysis of the Wang–Landau algorithm, which is designed for the direct Monte Carlo estimation of the density of states (DOS). In the case of a discrete energy spectrum, we present an approach based on introducing the transition matrix in the energy space (TMES). The TMES fully describes a random walk in the energy space biased with the Wang–Landau probability. Properties of the TMES can explain some features of the Wang–Landau algorithm, for example, the flatness of the histogram. We show that the Wang–Landau probability with the true DOS generates a Markov process in the energy space and the inverse spectral gap of the TMES can estimate the mixing time of this Markov process. We argue that an efficient implementation of the Wang–Landau algorithm consists of two simulation stages: the original Wang-Landau procedure for the first stage and a 1/t modification for the second stage. The mixing time determines the characteristic time for convergence to the true DOS in the second simulation stage. The parameter of the convergence of the estimated DOS to the true DOS is the difference of the largest TMES eigenvalue from unity. The characteristic time of the first stage is the tunneling time, i.e., the time needed for the system to visit all energy levels.
Effect of the cooling rate in the thermally driven differential mutation method
Authors: Biswas Katja 
Published: August 2019

Abstract
The thermally driven differential mutation algorithm is an evolutionary algorithm dealing with the structural optimization of large amorphous systems represented by empirical potentials. It is a hybrid algorithm that combines a differential mutation evolutionary algorithm with a metropolis selection criterion and a cooling schedule inspired by simulated annealing. In this manuscript, the influence of the cooling rate on the quality of obtained amorphous graphene structures is discussed.
Optimization production and distribution using production routing problem with perishable inventory (PRPPI) models
Authors: Dewi Novi Rustiana , Susanti Eka , Roflin Eddy , Octalia Tiara Bella , Novita Rika 
Published: August 2019

Abstract
This paper discussed about optimization production and distribution problem of tempe using Production Routing problem with Perishable Inventory (PRPPI) models with First Produce, First Deliver (FPFD) and First Produce First Selling (FPFS) inventory management policy. Tempe is a food made from soy fermentation and distributed from the depot to retailers. There are three retailers, namely Perumnas market, Sekip market and Kebon Semai market respectively as retailer 1, 2 and 3, and Ana depot is defined as retailer 0. An exact Branch and Bound algorithm was developed and solved by Lingo 17.0 Software. The results of minimum cost production and distribution retailer 0 was 69,174 rupiah, optimal amount of tempe production 34 pieces. The shipping routes starting from retailer 0 to retailer 1, proceed to retailer 2 and then to retailer 3 finally return to retailer 0.
Set covering models in optimizing the emergency unit location of health facility in Palembang
Authors: Sitepu Robinson , Puspita Fitri Maya , Romelda Setia , Fikri Ahmad , Susanto Beta , Kaban Hadir 
Published: August 2019

Abstract
Palembang comprises 16 districts, but in this research, the focus area is limited to 8 districts namely Sukarami, Sako, Sematang Borang, Kalidoni, Kemuning, Ilir Timur II, Seberang Ulu II, and Plaju. There are currently only 7 districts that have emergency installations. This research is designed to optimize the number and location of emergency installation in Palembang. Optimization of emergency installation location is required to improve health services in Palembang. This optimization uses covering-based models that include location set covering problem and maximal covering location problem. The solutions are obtained by using branch and bound solver on Lingo 13.0. The results of the computation with the best time of 15 minutes are 6 locations of emergency installations in order to serve the existing 8 districts.
Support vector machines for classification of low birth weight in Indonesia
Authors: Eliyati Ning , Faruk Alfensi , Kresnawati Endang Sri , Arifieni Ika 
Published: August 2019

Abstract
This paper proposes support vector machines (SVMs), which is currently one of the most popular algorithms in machine learning (ML), in order to classify the low birth weight (LBW) data. The main objectives of this study are to predict the classification of LBW data in Indonesia based on the SVMs andto compare the performance of the proposed SVMs with the binary logistic regression as the most common model for classification of LBW data. The obtained samples were based on the results of Indonesian Demographic and Health Survey in 2012. The results showed that SVMs with four kernel functions (linear, radial, polynomial and hyperbolic tangent) were fit well to the LBW data in Indonesia. Furthermore, the constructed SVMs based on linear kernel function had the best performance among the SVMs with the other proposed kernel functions. This research also concluded that the SVMs based on linear kernel competed well with thebinary logistic regression forclassification LBW data in Indonesia.
Timetable creation of BRT Trans Musi Palembang on AAL Ampera route
Authors: Irmeilyana  , Indrawati  , Amran Ali , Tomy Reyfaldo 
Published: August 2019

Abstract
Timetable creation is an integer linear programming in transportation scheduling. In this study, we used primary and secondary data of BRT Trans Musi Kota Palembang on AAL-Ampera route for bus operation time in each of the 2 periods in the morning (i. e. at 6 to 8 am) and afternoon (i.e. at 4 to 6 pm). The aim of this timetable creation is to find the optimal departure time of the bus in minimizing the density of passengers in the bus and in a halte (or tranfer node). We solved the problem by Branch and Bound method. Based on the results, headway in the morning is higher than afternoon time, especially for Ampera - AAL route. This means that passengers are transported on the route AAL - Ampera in the morning more than the afternoon. Conversely passengers for the route Ampera - AAL in the afternoon more than the morning. In the morning, the required number of buses for AAL - Ampera route is more than the Ampera - AAL route. By contrast, in the afternoon, the required number of buses for Ampera - AAL route is more numerous. The start time of operation on both routes in each period is relatively the same.
Analyzing characteristics of Songket Palembang weavers productivity using path analysis
Authors: Irmeilyana  , Desiani Anita , Ngudiantoro  , Alfarisy Salman , Andreani Putri Asia 
Published: August 2019

Abstract
Most of women in Desa Limbang Jaya work as songket weavers. Their products have good quality, but their level productivity is low, so it causes the income for them is low. There are characteristics that influence the level productivity of weaver. Path analysis is method that can be used to look for the characteristics that influence the productivity. In this paper, we use path analysis to find exogenous variables that effect directly and indirectly on endogenous variables. Exogenous variables in this paper consist of: age, education, work period, work motivation, work culture and business motivation. Endogenous variables consist of productivity and income. The obtained data by purposive sampling method consist of 104 songket weaver respondents. Characters that have a significant influence on the productivity of songket weavers in Limbang Jaya is education and business motivation. In the craftsman’s income, either with alpha 5% or 10%, no variable has a direct and indirectly significant effect.
The effect of oil palm shell ash to asphalt characteristics
Authors: Ritonga Winsyahputra , Ritonga Nila Yosefa , Rangkuti Muhammad Aswin , Eddiyanto  , Prawijaya Septian 
Published: August 2019

Abstract
This study aims to determine the effect of the addition of oil palm shell ash on the characteristics of asphalt and its mixtures. Palm shell is chosen as a filler material due to its content of silicon dioxide (SiO2) so that it is used as a suitable binder. This study consisted of several stages: (1) making modified bitumen; (2) testing modified bitumen with asphalt physical requirements method; (3) making and testing specimens; (4) Marshall testing. The results showed that the addition of oil palm shell ash resulted in increased asphalt stability values with the highest stability of 1553 kg from sample 4. Furthermore, the addition of oil palm shell ash resulted in increased asphalt flow values with the highest flow of 3,85 mm from sample 5. Based on the results of the research and discussion, it was concluded that there was an effect of the addition of oil palm shell ash on the characteristics of asphalt and its mixture.
Analysis crystal structure of magnetic materials Co1-xZnxFe2O4
Authors: Johan Akmal , Adi Wisnu Ari , Arsyad Fitri Suryani , Setiabudidaya Dedi 
Published: August 2019

Abstract
Modification of zinc substitution cobalt ferrite material is expected to be one of the microwave absorbing material candidates because it has single phase permittivity and permeability. Permitivity and permeability are engineered from the inter-substitution of atoms in the crystal lattice as a function of composition. Substitution of zinc into cobalt ferrite (Co1- xZnxFe2O4) for Zn2+ (x = 0 – 1) has been synthesized using the solid reaction method through mechanical deformation techniques. The results of refinement of X-ray diffraction patterns indicates that a single phase is obtained for all x compositions. Cubic structure formation with Fd3m space group, where the lattice parameter, lattice strain, cell unit volume, and atomic density change as a composition function. Morphological observations of particles using a scanning electron microscope showed that the particle size distribution was evenly distributed for all compositions with particle sizes ranging from 100-500 nm, whereas in each particle the average size of crystallite also changed as a function of composition. It was concluded that the effect of Zn substitution on Co1-xZnxFe2O4 resulted in changes in the crystal structure parameters as a function of composition with a uniform particle size distribution in all compositions.
Waste as fastest cycle of renewable energy sources through TOSS Model
Authors: Legino Supriadi , Hidayawanti Ranti , Wirantika Irma 
Published: August 2019

Abstract
Natural fossil formation takes several million years while coal consumption trends to be higher from time to time. Such unbalance condition leads to the faster decreasing reserve of oil, gas, and coal that will create various impacts for people in the future since they will have no fossil energy anymore. Therefore, many countries in the world make an effort to use various biomass as renewable energy sources alternatives. Unlike intermitten sources such as solar, wind, or tidal energy that cannot be storaged, biomass can be renewed and storage as similar to fossil fuel. However, it takes million decades to create fossil fuel like coal, gas, and oil, while biomass can be renewed in much shorter cycle. For examples, wooden biomass from natural forest or jungle will take around ten years cycle to grow, forest woods from cultivated plantation will take around five years cycle, and some kind of biomass take less than a year renewable cycle such as rice husk, straw, vetiver grass, and other cultivated plantation. Waste as a focal point of this study is a biomass with a shortest renewable cycle because human, animal, and plant produced waste continuously and its population is always increasing. STT PLN school of technology Jakarta has conducted study and pilot project to convert waste into pellet or briquette that can be used to replace coal, gas, or oil. This waste to energy model that takes only less than ten days to produce pellet from fresh waste is named TOSS, stand for tempat olah sampah stempat, means localized waste treatment. Therefore it can be stated that renewable cycle of waste, particularly municipal waste is only ten 10 days cycle. By using this renewable cycle approach, any kind of biomass value can be compared to the value of coal over certain period of time. For instance, 1000 ton of waste can be converted into at least 100 kg with 3000 kcal/kg equivalent pellet in 10 days. It means that 1000 ton of waste in only 100 days is equivalent to 1000 ton of low rank coal that takes million years to formed.