bluuebunny/crossref_metadata_2025_split huggingface dataset:
HAMPT, A Novel Quadruple Drug Combination Designed for Cancer Metastatic Chemoprevention: From Hypothesis to Proof-of-concept
Authors: Xu Huo , Wan Liyuan , Xu Jianguo , Liu Jian , Zheng Ning , Jia Lee 
Published: March 2019

Background:Highly Active Metastasis Preventing Therapy (HAMPT) is a quardruple drug combination consisting of mifepristone, aspirin, lysine and doxycycline.Objective:Based on our previous study, here, we further proved that HAMPT could effectively and safely prevent colon cancer metastasis.Methods:It was specifically designed for synergistically controlling key cancer metastatic pathways. The dose of HAMPT was designed at lower than the pharmaceutically-recommended dose, and thus the sub-healthy cancer survivors may take HAMPT safely and for a long time for metastasis chemoprevention.Results:HAMPT within its effective concentration range (1-50 &#181;g/mL) showed no cytotoxicity to colon cancer cells HT-29 and CT-26, but significantly inhibited adhesion and invasion of these colon cancer cell lines to human umbilical vascular endothelial cells (HUVECs), and to Matrigel. HAMPT exhibits a good adhesion inhibited ratio, suggesting that it functions primarily by inhibiting adhesion of the cancer cells to HUVECs, rather than killing the cancer cells. At low concentrations, HAMPT also inhibited cancer cell migration. Flow cytometry analysis revealed that HAMPT had no significant effect on cell cycle, but inhibited IL-1&#946;-induced expression of both E-selectin of HUVECs and Sialyl-Lewis X of HT-29. The in vivo experiment showed that HAMPT suppressed metastasis of CT-26 cells to mouse lungs in a dose-dependent manner. In the mouse model, HAMPT showed advantages in preventing metastasis over other combinations.Conclusion:The present study demonstrated that HAMPT is a novel quadruple drug combination that can safely and effectively prevent cancer metastasis.
FORMULATION ANDEVALUATION OF TRANSDERMAL DRUG DELIVERY OF TORASEMIDE
Authors: Yadav Sanjay Kumar , Gupta Ravikant , Malipatil S M , Gupta S K 
Published: March 2019

A skin patch uses a special membrane to control the rate at which the liquid drug contained in the reservoir within the patch can pass through the skin and into the bloodstream. The basic components of any transdermal delivery system include the drug(s) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing film of paper, plastic, or foil; and a pressure-sensitive adhesive that anchors the patch to the skin. The adhesive is covered by a release liner, which needs to be peeled off before applying the patch to the skin. Drugs administered via skin patches include scopolamine, nicotine, estrogen, nitroglycerin, and lidocaine.
Non-medicated patch markets include thermal and cold patches, nutrient patches, skin care patches (a category that consists of two major sub-categories-therapeutic and cosmetic), aroma patches, weight loss patches and patches that measure sunlight exposure.
Science Rewritten to Accommodate its Origin
Authors: Deans Michael T 
Published: March 2019

A ferroelectric phase transition in ice at ~72 K releases latent energy as λ ~ 4 μ infrared laser light, ‘ice light’, energizing selected targets. Polarized by multiple reflection[22], it photophosphorylated deoxynucleotides, turning tropical waters into a noodle soup of chiral DNA. tRNA analogues ‘transport DNAs’, tDNAs embedded in Alexander Oparin’s lightning-charged coacervates[23] formed H-bond lined pores. Absorbed ice light created an electric field, driving a ratchet mechanism which actively imported charged carrier-substrate complexes.
All life descends from the first cell to replicate a tDNA and depends on the trace element requirements of 64 tDNA variants. They constitute life’s atomic alphabet, their substrate complexes its molecular vocabulary. The inviolable rules of active transport predate protein synthesis and enzyme catalysis. Medical, veterinary and pharmaceutical data are consistent with nine independent metabolic pathways. My account of water transport contradicts Peter Mitchell’s chemiosmotic hypothesis.[24] Trace element deficiencies disabling active transport cause most mental and physical maladies, supplements could prevent them.
‘Differentiation DNAs’, dDNAs selecting tDNAs control cells’ substrate uptake, c.f. mRNAs encode protein synthesis by selecting tRNAs. Barrels of α-helices[25] supplement tDNAs and tDNA genetics governs familial inheritance of metabolic disorders, a minion-based data base would facilitate their diagnosis. Trace element supplements would prevent heart attacks, strokes, cancers, diabetes, Alzheimer’s dementia and rarer conditions, improve health and reduce NHS expenditure.
The 189*18 arrays of proton ordered H-bonds connecting amino acid ω-amines to DNA phosphates on ‘minions’ control metabolism, serve as biological clocks, memory stores and personality biased brain chips and are basis for reinterpreting scientific dogma. Nine parallel metabolic pathways reflecting their 9-fold symmetry control metabolism. Oscillating H-bonds accelerate protons along minion tunnels, driving molecular scale nuclear fusion. Trapping the γ-rays released at source could solve current energy and pollution crises. Computers and data-bases modelled on minions promise human-friendly artificial intelligence satisfying Turing’s criteria.[26]
Comparing cybernetics, psychology and traditional wisdom suggested ‘minions’, the name connotes subservience. They comprise 189 anti-parallel β-sheet hairpins[27] with alternate neutral and basic amino acid residues and proline forming an asymmetric U-bend. They hold nine DNA base pairs flat, forming a nine-coil abacus. Evolved to pack DNA on chromosomes for efficient replication, they underpin philosophy and science, account for human intelligence and resolve many questions. My mutually consistent arguments contradict accepted dogma.
The Effect of Incisional and/or Intraperitoneal Local Anesthetic Application on Postoperative Pain during Laparoscopic Cholecystectomy
Authors: Aydin Oguz Ugur , Aydin Eda Uysal , Dandin Ozgur , Ozer Etik Diğdem , Cekmen Nedım , Gogus Nermin 
Published: March 2019

Objective - In this study, we aimed to determine the effect of levobupivacaine (LB) application by intraperitoneal, incisional, and both together on postoperative pain after laparoscopic cholecystectomy.
Materials and Methods - One hundred ASA (American Society of Anesthesiologists) I-II patients undergoing laparoscopic cholecystectomy were recruited in the study. The patients were randomized into four groups: placebo group (P), incisional group (I), intraperitoneal group (IP), and the combined (incisional+intraperitoneal) group (C). In the postoperative period, pain in the patients during resting and coughing was evaluated after 30 min, 2, 4, 8, 12, and 24 hours by employing visual analogue scale (VAS) for pain. Applied analgesic quantity, shoulder pain, and the existence of nausea-vomiting were also recorded.
Results - Pain scores during resting and coughing were significantly lower in the combined group compared with others. Pain scores were similar in the incision and intraperitoneal groups, whereas in the placebo group were significantly lower. The analgesic need was lowest in the combined group and highest in the placebo group. There was no shoulder pain either in the combined or intraperitoneal groups. Nausea-vomiting rates were similar in all groups.
Conclusions - We conclude that combined application of 0.25 % levobupivacaine can be used as an effective and safe method for postoperative pain control after laparoscopic cholecystectomy.
How Using Technology Enhanced Learning Could Help Modernise Traditional Large Group Teaching or Lecturing
Authors: McMullan Mrs. Johanna 
Published: March 2019

The efficiency of lecturing or large group teaching has been called into question for many years. An abundance of literature details the components of effective teaching which are not provided in the traditional lecture setting, with many alternative methods of teaching recommended. However, with continued constraints on resources large group teaching is here to stay and student’s expect and are familiar with this method.
Technology Enhanced Learning may be the way forward, to prevent educators from “throwing out the baby with the bath water”. TEL could help Educator’s especially in the area of life sciences which is often taught by lectures to engage and involve students in their learning, provide feedback and incorporate the “quality” of small group teaching, case studies and Enquiry Based Learning into the large group setting thus promoting effective and deep learning.
The Progressive Study of Various Risk Factors on Insulin Resistance in Type 2 Diabetic Mellitus
Authors: Ashish Shukla Yogesh Kumar Rai, 
Published: March 2019

Objective - The current study have undertaken to explore the effect of various factors like non vegetarian diet, alcohol consumption, smoking and lack of physical activates which will going to an increased risk of insulin resistance
Material and Method - The study were conducted 78 subjects of type 2 diabeties in urban and rural area of meerut city. Fasting plasma glucose, fasting plasma insulin and HOMA- IR were analyzed. Three groups of subjects were made according to no of risk factor associated with insulin resistance.
Results - The study showed that Maximum HOMA-IR value were find in group c (Non- Vegetarian, Alcoholic, smoker with less physical work activates subjects) as compared to group a (Non- Vegetarian) and group b (Non- Vegetarian with Alcoholic). It is also found there were significant correlation between HOMA-IR value and no of risk factors p < 0.001.
Conclusion - There is convincing evidence that non vegetarian diet, alcohol consumption, smoking and less physical activates are related to an increased risk factors for insulin resistance in type 2 diabetes. The study concluded a significant progressive relationship between number of risk factor with respect to HOMA-IR levels which is an indices of insulin resistance.
“Filling the Void in the Web Space”- Microbiological Perspective of Toe Web Space Infections in a Tertiary Care Hospital
Authors: Gopi Dr. Anjana , Samreen Dr. Faiza , Jain Dr. Swati , C.K. Dr. Madhulatha 
Published: March 2019

Toe web space infections are the most common superficial dermatoses of the feet. They are often unnoticed and progress to cause discomfort. There is lack of enough evidence on the microbiological profile and antifungal susceptibility pattern.
Settings and Design: A prospective study was conducted between August 2015 to February 2017 in the Department of Microbiology at a tertiary care hospital.
Methods and Material: 200 samples were collected from interdigital spaces of Dermatology outpatients and inpatients. Bacterial and fungal pathogens were isolated and identified using conventional laboratory techniques. Antifungal susceptibility testing was done to determine the Minimum inhibitory concentration (MIC) by E-test. A small representative sample of Fusarium isolates were subjected to speciation by PCR and their MIC was determined by broth microdilution method for comparison.
Statistical analysis used: p value was determined by Chi square test using SPSS software.
Results: Our study demonstrated a male preponderance of 59 %, mostly between 41 to 50 years. Both the feet were affected in 43/48 (89.5 %) of the diabetic patients, the fourth web space being commonly involved. 198/200 (99%) of the samples were positive for either bacterial or fungal growth. There were a total of 156 fungal and 204 bacterial isolates. Out of 156 fungal isolates, Candida spp 62 (39.7 %) and Fusarium spp 50 (32 %) were the most common isolated yeast and mould respectively and 38 (24.3 %) dermatophyte species were isolated. Results of E-test and broth microdilution were comparable. Voriconazole and amphotericin B had lower MIC. Out of 204 bacterial isolates, Staphylococcus aureus 56 (27.4 %) and Pseudomonas aeruginosa 44 (21.5 %) were the most common isolates.
Conclusions: A good microbiological diagnosis would assist in the better alleviation of the symptoms and provide accurate treatment of web space infections.
Evaluation of Lipid Profile in Premature, Near-term and Term Newborn Infants
Authors: Kurrey Dr. Ram Manohar , J. Lall Dr. Kavita , Chandrakar Dr. Karan Singh 
Published: March 2019

In this study we evaluate the activity of lipid profile in premature, near term and term neonates. A total number of 68 newborn infants were selected for this study. They were delivered normally, or by caesarean section, and their gestational age was included. The infants with congenital anomalies or those, whose mothers had medical problems, were excluded from the study. The gestational age was determined according to the date of the last menstrual period, or the early ultrasound in 20 weeks of gestation. All the information related to the newborns and their mothers were recorded in the prepared forms. Following the delivery, blood samples were taken from the umbilical cord immediately, and were separated after clotting, for at least 30 min at room temperature. Serum was stored at 4°C to -80C for a maximum of 2 days, prior to the analysis. Total cholesterol, triglycerides and HDL were analyzed by enzymatic method using auto-analyzer. Serum Total Cholesterol estimated by enzymatic kit method, Triglyceride estimated by bioluminescent assay method and HDL-cholesterol estimated by phasphotungstate precipitation method manufactured by ERBS Transasia. LDL-C and VLDL-C calculated by Friedewald formula.
The three groups were significantly different, regarding the means of age, weight and cholesterol and LDL-C level, whereas no significant difference was observed concerning the level of triglyceride and HDL-C,. Gender has no effect on the level of cholesterol, triglyceride, HDL-C and LDL-C in the total population and in all subgroups (P value more than 0.05). On the basis of present study we assume that the cholesterol level was higher in those with prematurity and pre-term delivery, and is also inversely correlated with the infant’s birth weight. Therefore, we believe that monitoring, observation and early-lifestyle modifications may decrease the severity of atherosclerosis in the vessels in adulthood. This study says, it is evident that the total cholesterol and LDL cholesterol in premature and near term neonates was higher than a term neonates ; triglyceride and VLDL were higher in term neonates as compared to near term neonates. Fall in HDL was significantly observed in premature neonates than term neonates and near term neonates but no significance found in term and near term neonates.
Nihilism and Nothingness in The Play Entitled The Birthday Party (1957) With Special Reference To The Existential Philosophy
Authors: Ahashan Mohammad , Tiwari Dr. Sapna 
Published: March 2019

The two world-wars and its massive destruction and horror had a great impact on human mind. Inevitably complete cynicism , pessimism , alienation , nothingness , existentialism reflected in the literature of that time. Pinter's play The Birthday Party (1957) is based on the philosophy of existentialism which later on became the source for the " Theatre of the Absurd ". Albert Camus and Jean-Paul Sartre gave the philosophy of existentialism according to which the universe and man's experience in it are meaningless. All attempts by human mind to understand the world are futile . All philosophical systems and religion which claim that they can enable man to make sense of the world are delusive and useless. Albert Camus in The Myth of Sisyphus (1942) wrote :-
" In a universe that is suddenly deprived of illusions and of light , man feels a stranger. ... This divorce between man and his life, the actor and his setting constitutes the feeling of Absurdity. "
Perbaikan Sensitivitas Insulin Diabetes Melitus Tipe 2 oleh Media Terkondisi Sel Punca Mesensimal
Authors: Branitamahisi Bernadia 
Published: March 2019

Abstract: Type 2 diabetes mellitus is the highest prevalence among diabetes types, but there is no treatment that overcome obstacle in the process of surgery, rejection reactions, and increased complications that occur. The aim of this study was to investigate the insulin sensitivity improvement by Mesenchymal Stem Cell-Conditioned Medium(MSC-CM) through increased IRS-1 tyrosine phosphorylation (IRS-1tyr612) on the type 2 diabetic rat with and without treatment. This experimental study is purely laboratory Posttest Control Group using male Sprague Dawley rat, 7 weeks old and 150-200gram weight. Rat is divided into 3 research groups, K(-): normal control; K(+): diabetic control; P:treatment, type 2 DM rat+MSC-CM 0,1ml/200gBW ip. Giving MSC-CM is done every 3 days 10 times. On day 30 after therapy, an IRS-1tyr612 expression analysis was performed with skeletal muscle immunohistochemistry (IHC). Data analysis was performed by Kruskal-Wallis and Independent Sample T-test at 95% significance. Percentage of positive score of IRS-1tyr612 expression K(-)(75%)> P(62,5%)> K(+)(12,5%). Average expression of IRS-1tyr612 P(45,46±9,15)> K(-)(44,41±4,61)> K(+)(21,29±3,49) with significant difference of K(-)-K(+) and P-K(+). Giving MSC-CM may increase the expression of IRS-1tyr612 on type 2 diabetic animal model rat.
Keywords: MSC-CM, insulin sensitivity, IRS-1tyr612, type 2 DM

Abstrak: Diabetes melitus tipe 2 merupakan tipe diabetes dengan prevalensi tertinggi, namun belum ada pengobatan yang dapat mengatasi hambatan dalam proses operasi, reaksi rejeksi, dan banyaknya komplikasi yang terjadi. Penelitian ini bertujuan untuk mengetahui perbaikan sensitivitas insulin oleh Media Terkondisi Sel Punca Mesensimal (MT-SPM) melalui peningkatan fosforilasi tirosin 612 IRS-1(IRS-1tyr612) pada tikus model DM tipe 2 dengan dan tanpa terapi. Penelitian ini eksperimental murni laboratorium Posttest Control Group menggunakan hewan uji tikus Sprague Dawley jantan usia 7 minggu dan berat badan 150-200gram. Tikus dibagi menjadi 3 kelompok penelitian, yaitu K(-): kontrol normal; K(+): kontrol diabetik; P: perlakuan, tikus DM tipe 2 + MT-SPM 0,1ml/200g bb ip. Pemberian MT-SPM dilakukan setiap 3 hari sebanyak 10 kali. Pada hari ke-30 setelah terapi, dilakukan analisis ekspresi IRS-1tyr612 dengan IHC otot skelet. Analisis data dilakukan dengan Independent Sample T-test dan Kruskal Wallis pada signifikansi 95%. Prosentase skor positif ekspresi IRS-1tyr612 K(-)(75%) > P(62,5%) > K(+)(12,5%). Rerata ekspresi IRS-1tyr612 P(45,46±9,15) > K(-)(44,41±4,61) > K(+)(21,29±3,49) dengan perbedaan yang bermakna secara statistik pada K(-)–K(+) dan P–K(+). Pemberian MTSPM dapat meningkatkan ekspresi IRS-1tyr612 pada tikus model DM tipe 2.
Kata kunci: MT-SPM, sensitivitas insulin, IRS-1tyr612,DM tipe 2
Sistem Pengaturan Penggunaan Perangkat Listrik Rumah Tangga Menggunakan Komputer Mini Hemat Daya
Authors: Leong Hironimus , E.A. Suyanto 
Published: March 2019

Abstract: The use of household electrical appliances can be controlled automatically by utilizing computer that can control when the device is switched on or off according to the schedules and conditions provided by the user.
Provisions and schedules can be determined by the user through software management that regulates the date and time regularly or specifically.
By utilixing "Rasberry Pi" energy saving mini computer that that is equipped with special software, electrical control center can be connected to the mini computer and the user can use integrated software to control the use of household electrical appliances according to the need on determined schedules.
The final goal of this research is to produce computer based system to manage the electric use that results in the efficiency of the use of electricity in the household and to create smart house that environmentally friendly
Keywords: electrical devices, management, setting, rasberry pi, saving power

Abstrak: Penggunaan perangkat listrik rumah tangga dapat dikendalikan secara automatis dengan memanfaatkan kemampuan komputer yang mampu mengontrol kapan perangkat tersebut dinyalakan atau dimatikan sesuai dengan jadwal dan ketentuan yang diberikan oleh pengguna.
Ketentuan dan jadwal dapat ditentukan oleh pengguna melalui software manajemen yang mengatur waktu tanggal dan jam baik secara regular maupun jadwal dan jam yang berlaku secara khusus atau spesifik.
Dengan memanfaatkan komputer mini hemat “Raspberry Pi” dan dilengkapi dengan software khusus, maka pusat kontrol listrik dapat dihubungkan ke komputer mini tersebut dan pengguna dapat memanfaatkan software terintegrasi untuk mengatur penggunaan perangkat listrik rumah tangga sesuai dengan kebutuhan pada jadwal-jadwal yang sudah ditentukan.
Tujuan akhir dari penelitian ini adalah menghasilkan sistem berbasis komputer untuk mengatur penggunaan listrik yang berdampak pada efisiensi penggunaan listrik dalam rumah tangga serta menciptakan rumah pintar yang ramah lingkungan.
Kata kunci: perangkat listrik, manajemen, pengaturan, raspberry pi, hemat daya
Analisis Kritis Atas Kebijakan Revaluasi Aset Kementerian Keuangan Tahun 2015
Authors: Butar Butar Sansaloni 
Published: March 2019

Abstract
The objectives of the paper is to analyze critically the new regulation that was introduced in 22 October 2015. Indonesian government issued Regulation No. 191 / PMK.010 / 2015 aimed at getting companies to revalue their fixed asset. Under the new regulation, firms may take advantage of lower tax rate imposed on revaluation surplus.Minister of Finance believes that firm future performance will increasas the value of asset rises.The arguments go further by stating thatfirmthat has intention to offerstocks publicly for the first time would also find it beneficial. At the surface the arguments put forward by the government is quiet understandable. However, a deeper analysis shows these arguments are not based on a sound understanding of financial reporting proceduresgoverned by Indonesian Financial Accounting Statement. In summary, there are at least three fundamental weaknesses contained in the arguments: First, the government tends to forget the differences in the calculation of earnings (revenue) for tax purposes versus external reporting purposes, especially for investors and creditors. Second, equating the responsibility of private and public companies in terms of adhering to rules and standards. Third, Presuming that asset value alone determines the firms’future performance.
Keywords: Asset revaluation, operating performance, taxable income,
financial reporting.

Abstrak
Tulisan ini bertujuan untuk menganalisis secara kritis regulasi revaluasi aset yang dikeluarkan pemerintah tanggal 22 Oktober 2015. Pemerintah menerbitkan PMK No. 191/PMK.010/2015 yang diarahkan untuk mendorong perusahaan melakukan revaluasi aset. Regulasi yang baru ini menawarkan insentif pajak atas selisih nilai aset tercatat dan harga pasarnya pasca revaluasi. Menteri keuangan percaya bahwa dengan menaikkan nilai aset sesuai harga pasarnya akan meningkatkan kinerja perusahaan. Alasannya, dengan nilai aset yang tinggi, kemampuan perusahaan untuk mendapatkan kredit akan meningkat dan akan mendorong kinerja perusahaan di masa mendatang. Selain itu, perusahaan yang sedang mempertimbangkan untuk melakukan IPO akan diuntungkan karena memiliki nilai aset yang lebih tinggi. Sepintas argumen-argumen yang dikemukakan oleh pemerintah memang dapat dimengerti. Namun analisis yang lebih mendalam menunjukkan argumen-argumen itu tidak didasari pemahaman yang benar tentang prosedur pelaporan keuangan yang diatur dalam PSAK. Argumen yang dikemukakan juga cenderung menyederhanakan faktor-faktor yang mempengaruhi kinerja operasi di masa mendatang. Setidaknya ada tiga kelemaham mendasar: pertama, pemerintah cenderung melupakan perbedaan perhitungan pendapatan (laba) untuk tujuan pajak dan untuk pelaporan keuangan eksternal, khususnya ditujukan bagi investor dan kreditor. Kedua, menyamakan tanggung jawab perusahan privat dan publik dalam ketaatan terhadap peraturan. Ketiga, anggapan bahwa aset menentukan kinerja perusahaan.
Kata Kunci: revaluasi aset, kinerja operasi, laba kena pajak, pelaporan keuangan