bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor
Authors: Ortiz Michael V. , Ahmed Saima , Burns Melissa , Henssen Anton G. , Hollmann Travis J. , MacArthur Ian , Gunasekera Shehana , Gaewsky Lyvia , Bradwin Gary , Ryan Jeremy , Letai Anthony , He Ying , Naranjo Arlene , Chi Yueh-Yun , LaQuaglia Michael , Heaton Todd , Cifani Paolo , Dome Jeffrey S. , Gadd Samantha , Perlman Elizabeth , Mullen Elizabeth , Steen Hanno , Kentsis Alex 
Published: December 2018

AbstractWilms tumor (WT) is the most common childhood kidney cancer. To improve risk stratification and identify novel therapeutic targets for patients with WT, we used high-resolution mass spectrometry proteomics to identify urine tumor markers associated with WT relapse. We determined urine proteomes at diagnosis of 49 patients with WT, non-WT renal tumors, and age-matched controls, leading to the quantitation of 6,520 urine proteins. Supervised analysis revealed specific urine markers of renal rhabdoid tumors, kidney clear cell sarcomas, renal cell carcinomas, as well as those detected in cured and relapsed WT. In particular, urine prohibitin was significantly elevated at diagnosis in patients with relapsed as compared to cured WT. In a validation cohort of 139 patients, a specific urine prohibitin enzyme-linked immunosorbent assay demonstrated that prohibitin concentrations greater than 998 ng/mL at diagnosis were significantly associated with ultimate WT relapse. Immunohistochemical analysis revealed that prohibitin was highly expressed in primary WT specimens and associated with disease stage. Using functional genetic experiments, we found that prohibitin was required for the growth and survival of WT cells. Overexpression of prohibitin was sufficient to block intrinsic mitochondrial apoptosis and to cause resistance to diverse chemotherapy drugs, at least in part by dysregulating factors that control apoptotic cytochrome c release from mitochondrial cristae. Thus, urine prohibitin may improve therapy stratification, non-invasive monitoring of treatment response and early disease detection. In addition, therapeutic targeting of chemotherapy resistance induced by prohibitin dysregulation may offer improved therapies for patients with Wilms and other relapsed or refractory tumors.
HOOK3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein and KIF1C
Authors: Kendrick Agnieszka A. , Redwine William B. , Tran Phuoc Tien , Vaites Laura Pontano , Dzieciatkowska Monika , Harper J. Wade , Reck-Peterson Samara L. 
Published: December 2018

AbstractThe unidirectional and opposite-polarity microtubule-based motors, dynein and kinesin, drive long-distance intracellular cargo transport. Cellular observations support the existence of mechanisms to couple opposite polarity motors: in cells some cargos rapidly switch directions and kinesin motors can be used to localize dynein. We recently identified an interaction between the cytoplasmic dynein-1 activating adaptor HOOK3 and the kinesin-3 KIF1C. Here we show that KIF1C and dynein/dynactin can exist in a single complex scaffolded by HOOK3. Full-length HOOK3 binds to and activates dynein/dynactin motility. HOOK3 also binds to a short region in the “tail” of KIF1C, but unlike dynein/dynactin, this interaction does not affect the processive motility of KIF1C. HOOK3 scaffolding allows dynein to transport KIF1C towards the microtubule minus end, and KIF1C to transport dynein towards the microtubule plus end. We propose that linking dynein and kinesin motors by dynein activating adaptors may be a general mechanism to regulate bidirectional motility.
The effects of entrepreneurial orientation on the performance of the Malaysian manufacturing sector
Authors: Loong Lee Wee , Chong Aik Lee , T. Ramayah 
Published: December 2018

PurposeThe purpose of this paper is to examine the effects of entrepreneur orientation (EO) on firm performance of the Malaysian manufacturing sector.Design/methodology/approachData for the study were collected through a survey of 321 companies registered with the Federation of Malaysian Manufacturers. Responses were analyzed using PLS-SEM to assess the relationships between transformational leadership and firm performance.FindingsThe findings show that amongst Malaysian manufacturers, transformational leadership has a strong direct effect on firm performance.Practical implicationsThese findings provide useful insights for organizations, particularly in the Malaysian manufacturing sector, seeking to be competitive and responsive to environmental changes by successfully introducing EO.Originality/valueEO has been studied in detail in the recent literature. Many new researchers have explored various composition factors of EO, and how this will have an effect on firm performance. However, there are few research studies in the area of transformational leadership amongst Malaysian manufacturing companies. This research makes an important contribution to the existing literature by empirically examining the relationship between EO and firm performance, particularly in the Malaysian manufacturing sector. Conclusion emphasizes that mechanisms to encourage and foster EO mainly autonomy, competitive aggressiveness and proactiveness are likely to result in the achievement of superior firm performance.
Technology forecasting (TF) and technology assessment (TA) methodologies: a conceptual review
Authors: Haleem Abid , Mannan Bisma , Luthra Sunil , Kumar Sanjay , Khurana Sonal 
Published: December 2018

Purpose
Technology forecasting (TF) and assessment (TA), all in all, apply to any intentional and deliberate endeavours to forecast and view the potential heading, rate, attributes and impacts of technological change, especially for development, advancement, selection and utilisation of resources, which ultimately helps in the benchmarking. A vast variety of methods are available for TF and TA. Till now, practically, no exertion has been made to choose proper, satisfactory innovation methods or technology. The paper aims to discuss this issue.

Design/methodology/approach
In this paper, there is an endeavour to summarise the vast field of TF and TA, through its evolution, functions, applications and techniques. This paper provides the in-depth review of the utilisation of TF and TA methodologies and its improvement, which helps the users in selecting the appropriate method of TF and TA for a specific situation.

Findings
This study concludes that the quest for a single strategy for doing forecast and assessment is a misconception. This neglects to perceive that forecast and assessment oblige a suitable blend of strategies and methods drawn from a variety of fields. Researchers and practitioners must be innovative, imperative and specialised in choosing TF and TA methodologies, and cannot be programmed.

Practical implications
The technology seems to be the most significant driver of the present day global developments. Some technologies have far-reaching implications, and the authors need to understand these issues regarding its’ forecasting and its assessment.

Originality/value
The decision of proper worthy procedure amid a circumstance may have an impact on the exactness and reliability of the forecast and assessment. Significant observations regarding learning, action/s, actor/s and expected outcomes are discussed.
Does experience stimulate or stifle creativity?
Authors: Tien Han-Kuang , Chang Bang-Lee , Kuo Yen-Ku 
Published: December 2018

PurposeThe purpose of this paper is to explore if experience stimulates or stifles creativity. It shows that accumulation of work experience improves an individual’s judgment and reduces divergent thinking of creativity.Design/methodology/approachThis study examines the factors influencing individual creativity, including the impact of work experience, using 509 responses to questionnaires from 500 top construction companies. The research hypothesis is evaluated using structural equation modeling.FindingsThe main factors affecting individual creativity are a positive mind-set, self-directed learning, and low self-monitoring. Self-directed learning has the greatest influence on the creativity of individuals with accumulated work experience, while low self-monitoring influences the creativity of people with less work experience.Research limitations/implicationsA better way to study individual creativity is longitudinal research, which involves long-time observation of the life cycle of creativity among organizational members, who are like products with a life cycle. Further study is necessary to show why some members are creative only for a short time (short life cycle) while some are creative for a longer (very long life cycle) period.Originality/valueThis study finds that employee creativity derives from the self-directed learning process as it helps to accumulate experience. This result indicates that construction firms can train employees to improve their self-directed learning and boost creativity. Experienced workers need more attention because they are trapped in their previous experience and it is difficult to train them.
Idea selection using innovators and early adopters
Authors: Sääksjärvi Maria , Hellén Katarina 
Published: December 2018

Purpose
Development of new products is important for firm success; however, firms often struggle to identify the best ideas from multiple options. The purpose of this paper is to study how innovators and early adopters can be used for identifying the best ideas, i.e. the ideas that appeal to mass-market customers.

Design/methodology/approach
Two empirical studies were conducted. Study 1 concerned the development of a symbolic innovation, whereas Study 2 focused on a functional innovation. Each study consisted of two parts: idea generation and idea evaluation. In Study 1 there were 124 idea generators and 248 idea evaluators. In Study 2 there were 104 idea generators and 108 evaluators.

Findings
Both studies demonstrate that innovators and early adopters are able to predict the ideas that appeal to mass-market customers. Yet, it was also shown that this prediction depends on the nature of the idea. In the case of ideas for products that are predominantly symbolic in nature (Study 1), innovators and early adopters predict the buying intentions of mass-market consumers via the perceived novelty of the idea. In turn, for ideas that are predominantly functional in nature, innovators and early adopters predict the buying intentions of mass-market consumers directly via buying intentions.

Originality/value
These findings show that innovators and early adopters can be used for selecting the best ideas from a plethora of available options. This is the first time that innovators and early adopters have been empirically demonstrated to hold such a role.
Are information quality and source credibility really important for shared content on social media?
Authors: Dedeoglu Bekir Bora 
Published: December 2018

PurposeThis paper aims to first examine tourists’ perceptions of the source credibility and information quality of social media content to see whether they would have an impact on their perceptions of the importance of shared content on social media. The moderating role of gender in this relationship was then examined.Design/methodology/approachThe research sample was composed of domestic and foreign tourists in Alanya, an important tourist destination in Turkey. The data in the current study were collected by the questionnaire method. The structural relationships in the research were examined using the partial least squares structural equation modeling, and the moderating effect of gender was examined via the partial least squares multiple group analysis.FindingsAccording to the research findings, tourists’ perceptions of source credibility regarding social media content had a positive impact on the importance attached to non-participant shared content, whereas their perceptions of information quality had a positive impact on the importance attached to participant shared content. Furthermore, it was also observed that gender had a moderating effect on the relationship between information quality and source credibility perceptions and the importance of shared content on social media.Originality/valueTwo important predictive variables have been examined in the current research in term of customer-generated contents. It has been demonstrated that the effects of these predictive variables on different customer-generated types could be different. Furthermore, it has been determined that the effects of these influences differ according to the gender of the individuals following the content. Thus, the current study provides significant findings to understand the impacts of these variables on the basis of gender.
Addressing mass-customization trade-offs in bottom of the pyramid markets
Authors: Ahrens Fred , Dobrzykowski David , Sawaya William 
Published: December 2018

Purpose
Manufacturers find bottom of the pyramid (BOP) markets challenging to serve due to low margins and highly localized needs. As such, residents in BOP markets often go without products commonly available in developed countries. Going without medical equipment may negatively affect healthcare services. This study develops a supply chain design strategy that supports the production of medical equipment by preserving variety flexibility at low volumes that stands to create new market opportunities for manufacturers and improve healthcare for residents in BOP markets.

Design/methodology/approach
The authors introduce a mass-customization model called options-based planning (OBP) which offers a framework to both leverage the efficiencies of high volume production models and provide products that are customized to local market needs. An empirical simulation, grounded in data collected from a large international manufacturer of magnetic resonance imaging (MRI) equipment, illustrates how an OBP production strategy will likely perform under BOP conditions and facilitate the delivery of healthcare equipment to BOP markets.

Findings
OBP provides a means for manufacturers to provide the customization necessary to serve fragmented BOP markets, while enabling higher production volume to make serving these markets more feasible. The empirical simulation reveals the relative benefits of OBP under conditions of forecast uncertainty, product complexity (number of design parameters) and different levels of responsiveness.

Social implications
Increased access to modern medical equipment should improve healthcare outcomes for consumers in BOP markets.

Originality/value
The MRI context in BOP markets serves to illustrate the value of the OBP model for manufacturers.
A dyadic perspective of socially responsible mechanisms for retailer-manufacturer relationship in an apparel industry
Authors: Yadlapalli Aswini , Rahman Shams , Rogers Helen 
Published: December 2018

Purpose
The purpose of this paper is to identify and prioritise social responsible mechanisms in apparel supply chains to extend social responsibility from large retailers in developed countries to producers in developing nations.

Design/methodology/approach
A framework that consists of supplier qualification and supplier relational mechanisms as two socially responsible mechanisms, with five factors and 18 dimensions is proposed. To prioritise the dimensions, analytic hierarchy process is employed by using a case study methodology of a major Australian retailer sourcing from Bangladesh manufacturers.

Findings
Results indicate that at the mechanism level, both retailer and manufacturers perceive qualification of manufacturer as by far the most critical element compared to the relational mechanism. However, substantial differences exist at the factor level; namely, that the social factor is critical for the retailer, whereas the economic factor is critical for the manufacturer. Within the relational mechanism, evaluation helps retailers to enforce social responsibility, while manufacturers believe collaboration helps.

Research limitations/implications
The major limitation of this study is the generalisation of the findings. The results obtained by focusing on a particular context in the Australian retail sector importing from Bangladesh, may not be applicable to other nations.

Practical implications
By highlighting the difference of opinion, this study assists managers in developing guidelines to better understand the socially responsible mechanisms in the retailer-manufacturer dyadic relationship and to propose strategies to address the differences.

Originality/value
This study advances the literature on inter-organisational relationship to retailer-manufacturer dyad for the implementation of social responsibility by including supplier qualification along with supplier relational mechanism.
Logistics and distribution innovation in China
Authors: Amling Alan , Daugherty Patricia J. 
Published: December 2018

Purpose
The purpose of this paper is to explore how two mega-trends, e-commerce and urbanization, have the potential to reshape logistics practices around the world. Primary focus is on how Chinese business practices and logistics innovations are increasingly relevant to the USA and other western countries.

Design/methodology/approach
Experience-based thought piece focusing on specific Chinese logistics innovations centering on speed, adaptability and new business models.

Findings
The Chinese economy has played a key role in providing support and enabling logistics innovations in China. Key enablers include the ubiquitous connectivity and applications availability, the dynamic low-cost labor environment and government support for the Chinese logistics industry.

Research limitations/implications
This study suggests new areas for research.

Practical implications
This study provides insights into the potential value associated with adopting innovative Chinese logistics practices.

Social implications
This study provides suggested areas of attention to help focus on logistics operations on key societal trends.

Originality/value
Our paper provides insights into the potential value associated with adopting innovative Chinese logistics practices. We believe this represents a significant contribution as little coverage of the topics have been noted to date in leading logistics/supply chain journals.
An approach to quantify integration quality using feedback on mapping results
Authors: Serrano Fernando R.S. , Fernandes Alvaro A.A. , Christodoulou Klitos 
Published: December 2018

Purpose
The pay-as-you-go approach to data integration aims to reduce the time and effort required by proposing a bootstrap phase in which algorithms, rather than experts, identify semantic correspondences and generate the mappings. This highly automated bootstrap phase is likely to be of low quality, thus pay-as-you-go approaches postulate a subsequent continuous improvement phase based on user feedback assimilation to improve the quality of the integration. The purpose of this paper is to quantify the quality of a speculative integration, using one particular type of feedback, mapping results, whilst taking into account the uncertainty of user feedback provided.

Design/methodology/approach
The authors propose a systematic approach to quantify the quality of an integration as a conditional probability given the trustworthiness of the workers. Given a set of mappings and a set of workers of unknown trustworthiness, feedback instances are collected in the extents of the mappings that characterize the integration. Taking into account the available evidence obtained from worker feedback, the technique provides a quality quantification of the speculative integration.

Findings
Experimental results on both synthetic and real-world scenarios provide valuable empirical evidence that the technique produces a cost-effective quantification of integration quality that faithfully reflects the judgement of the workers whilst taking into account the inherent uncertainty of user feedback.

Originality/value
Current pay-as-you-go techniques provide a limited view of the integration quality as the result of feedback assimilation. To the best of the authors’ knowledge, this is the first proposal for quantifying integration quality in a systematic and principled manner using mapping results as a piece of evidence while at the same time considering the uncertainty inherited from user feedback.
Giving from the heart: exploring how ethics of care emerges in corporate social responsibility
Authors: Formentin Melanie , Bortree Denise 
Published: December 2018

PurposeThe purpose of this paper is to examine philanthropic partnerships between donor organizations and nonprofits and how ethics of care may play an important role in the quality of relationship between the partners.Design/methodology/approachIn total, 29 in-depth interviews were conducted with communications professionals at nonprofit organizations to understand how their partnerships with national sport organizations benefited their organizations and how characteristics of the sport organizations’ communication and behavior have consequence for their partners.FindingsThe four dimensions of ethics of care (building trust, showing mutual concern, promoting human flourishing and responsiveness to needs) clearly emerged as the most beneficial ways sport organizations engage with their nonprofit partners.Research limitations/implicationsThis study introduces the concept of ethic of care into the CSR literature and suggests that ethics of care may play an important role in relationship management with key publics.Practical implicationsPractically, this study offers insights for corporate partners about the way their communication and behavior influence nonprofits, and it suggests ways that corporations can improve their work with partners to create a more productive relationship.Originality/valueThis is one of the first studies to use ethics of care to examine the relationship of CSR partnerships and the first to conduct a study with sport organizations.
A bibliometric analysis of research on Big Data analytics for business and management
Authors: Ardito Lorenzo , Scuotto Veronica , Del Giudice Manlio , Petruzzelli Antonio Messeni 
Published: December 2018

Purpose
The purpose of this paper is to scrutinize and classify the literature linking Big Data analytics and management phenomena.

Design/methodology/approach
An objective bibliometric analysis is conducted, supported by subjective assessments based on the studies focused on the intertwining of Big Data analytics and management fields. Specifically, deeper descriptive statistics and document co-citation analysis are provided.

Findings
From the document co-citation analysis and its evaluation, four clusters depicting literature linking Big Data analytics and management phenomena are revealed: theoretical development of Big Data analytics; management transition to Big Data analytics; Big Data analytics and firm resources, capabilities and performance; and Big Data analytics for supply chain management.

Originality/value
To the best of the authors’ knowledge, this is one of the first attempts to comprehend the research streams which, over time, have paved the way to the intersection between Big Data analytics and management fields.