bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of haystacks by wolves may facilitate the transmission of sarcoptic mange
Authors: Bojarska Katarzyna , Orłowska Blanka , Sobociński Wojciech , Karczewska Małgorzata , Kołodziej-Sobocińska Marta 
Published: November 2024

AbstractWildlife that use anthropogenic resources often come into conflict with humans, e.g. due to damaged property, habituation or transmission of pathogens, amongst them Sarcoptes scabiei, the aetiological agent of sarcoptic mange, an emerging panzootic skin disease. This study examines the use of haystacks intended for supplementary feeding of European bison (Bison bonasus) by wolves (Canis lupus) with sarcoptic mange and the potential role of this behaviour in skin parasite transmission and human-wolf conflict. Hay samples from the beds used by wolves were found to harbour S. scabiei mites, even several days after the last use. Our data demonstrate an unforeseen link between wild ungulate supplementary feeding and wolf behaviour that may lead to conflict, namely approaching human settlements. However, no negative interactions were observed between wolves and humans or domestic animals. The presence of S. scabiei mites in haystacks provides a potential for its human-facilitated environmental transmission among wildlife and to domestic animals.
Comparison of retinol binding protein 1 with cone specific G-protein as putative effector molecules in cryptochrome signalling
Authors: Yee Chad , Bartölke Rabea , Görtemaker Katharina , Schmidt Jessica , Leberecht Bo , Mouritsen Henrik , Koch Karl-Wilhelm 
Published: November 2024

AbstractVision and magnetoreception in navigating songbirds are strongly connected as recent findings link a light dependent radical-pair mechanism in cryptochrome proteins to signalling pathways in cone photoreceptor cells. A previous yeast-two-hybrid screening approach identified six putative candidate proteins showing binding to cryptochrome type 4a. So far, only the interaction of the cone specific G-protein transducin α-subunit was investigated in more detail. In the present study, we compare the binding features of the G-protein α-subunit with those of another candidate from the yeast-two-hybrid screen, cellular retinol binding protein. Purified recombinant European robin retinol binding protein bound retinol with high affinity, displaying an EC50 of less than 5 nM, thereby demonstrating its functional state. We applied surface plasmon resonance and a Förster resonance transfer analysis to test for interactions between retinol binding protein and cryptochrome 4a. In the absence of retinol, we observed no robust binding events, which contrasts the strong interaction we observed between cryptochrome 4a and the G-protein α-subunit. We conclude that retinol binding protein is unlikely to be involved in the primary magnetosensory signalling cascade.
A redox-related lncRNA signature in bladder cancer
Authors: Zhao Fuguang , Xie Hui , Guan Yawei , Teng Jingfei , Li Zhihui , Gao Feng , Luo Xiao , Ma Chong , Ai Xing 
Published: November 2024

AbstractThe redox status is intricately linked to the development and progression of cancer, a process that can be modulated by long non-coding RNAs (lncRNAs). Previous studies have demonstrated that redox regulation can be considered a potential therapeutic approach for cancer. However, the redox-related lncRNA predictive signature specific to bladder cancer (BCa) has yet to be fully elucidated. The purpose of our study is to establish a redox-related lncRNA signature to improve the prognostic prediction for BCa patients. To achieve this, we downloaded transcriptome and clinical data from the Cancer Genome Atlas (TCGA) database. Prognostic redox-related lncRNAs were identified through univariate Cox regression, least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression analysis, resulting in the establishment of two risk groups. A comprehensive analysis corresponding to clinical features between high-risk and low-risk groups was conducted. Eight redox-related lncRNAs (AC018653.3, AC090229.1, AL357033.4, AL662844.4, AP003352.1, LINC00649, LINC01138, and MAFG-DT) were selected to construct the risk model. The overall survival (OS) in the high-risk group was worse than that in the low-risk group (p < 0.001). The redox-related lncRNA signature exhibits superior predictive accuracy compared to traditional clinicopathological characteristics. Gene Set Enrichment Analysis (GSEA) showed that the MAPK signaling pathway and Wnt signaling pathway were enriched in the high-risk group. Compared with the low-risk group, patients in the high-risk group demonstrated increased sensitivity to cisplatin, docetaxel, and paclitaxel. Furthermore, IGF2BP2, a potential target gene of MAFG-DT, was found to be overexpressed in tumor tissues and correlated with overall survival (OS). Our study demonstrated that the predictive signature based on eight redox-related lncRNAs can independently and accurately predict the prognosis of BCa patients.
An MPPT method using phasor particle swarm optimization for PV‐based generation system under varying irradiance conditions
Authors: Sajid Injila , Sarwar Adil , Tariq Mohd , Ahmad Shafiq , Bakhsh Farhad Ilahi , Mohamed Adamali Shah Noor , Islam Md. Rasidul 
Published: November 2024

AbstractThe dependency of photovoltaic (PV) systems‐based generation systems on constantly varying temperatures and incident sunlight affect the non‐linear behaviour of PV panels. Therefore, tracking the maximum power output of the PV panels for efficient utilization becomes a challenge, resulting in power losses and the creation of intense heating spots in the shaded areas of the PV modules when the PV modules receive varying degrees of insolation, that is, under partial shading conditions (PSCs). The inclusion of bypass diodes in parallel to each PV module mitigates this problem to an extent but leads to the formation of several peaks in the P‐V characteristics. As a result, maximum power point tracking (MPPT) to deliver maximum power at the load becomes a limitation for conventional optimization algorithms as they are normally based on hill climbing algorithm and get stuck at local maxima of the P‐V curve. Therefore, metaheuristic algorithms are used thereby eliminating the possibility of getting trapped at the local optima. However, particle swarm optimization (PSO) suffers from delayed convergence, more iterations to reach the optimal point, and random parameter selection. Hence, this study employs an improved version of PSO called Phasor‐PSO (P‐PSO) in an MPPT controller. The proposed algorithm is parameter‐less which results in reduced computational complexity and thus provides quick decision in achieving the maximum power point (MPP). The hardware‐in‐loop real‐time analysis demonstrates the supremacy of P‐PSO over PSO in faster convergence, higher efficiency, and reduced power losses during tracking under various PSCs. The P‐PSO based MPPT method will find application in grid connected and stand‐alone solar PV system with better efficiency of power transfer.
Early Treatment-Resistance in First Episode Psychosis
Authors: Fernando Piyumi , Strauss Johanna , Wagner Elias , Löhrs Lisa , Campana Mattia , Falkai Peter , Hasan Alkomiet , Papazova Irina 
Published: November 2024

Abstract
Introduction Approximately 30% of individuals with schizophrenia
experience treatment resistance (TR), with 70% exhibiting it from the onset.
Most research fails to distinguish between acquired and innate resistance, with
limited data on TR in first episode psychosis (FEP). However, FEP patients with
TR experience progressively worse outcomes compared to those with initial
response. To further understand these findings, clinical and demographic data of
FEP patients with and without TR were compared in this naturalistic study.
Methods Information was extracted on FEP patients who were
antipsychotic-naive at the time of admission from a retrospective database on
F2x diagnosed patients admitted to the LMU psychiatric clinic between 2008 and
2018. Clozapine was used at discharge as a marker of TR in the FEP cohort. A
similarly antipsychotic-naïve FEP control group without clozapine at discharge,
was generated by matching for gender and age. Thirty clinical and demographic
variables were analyzed to identify differences.
Results Two-hundred forty antipsychotic-naive FEPs were included: 33 with
clozapine at discharge (TRC group), and 207 in the control group (non-TRC).
Significant differences were observed in inpatient stay duration,
chlorpromazine-equivalent dosage, number of antipsychotics, and anticholinergic
medication at discharge.
Discussion The findings indicate that longer inpatient stay, an increased
number of antipsychotics, and possibly a more extended prodrome may serve as
markers for non-clozapine TR in FEP. Further research is necessary to establish
the robustness of these variables as early-stage TR markers.
Endovascular Repair of Zone 0 Ascending Aortic Aneurysm: A Review of Current Knowledge and Developing Technology
Authors: Halbert Sarah , Kucera John , Antevil Jared , Nagy Christian , Sarin Shawn , Trachiotis Gregory 
Published: November 2024

AbstractAortic aneurysms represent the 15th leading cause of death in men and women over 55 years of age. Where historically these lesions were all addressed via an open approach, endovascular aortic repair has entirely altered the way that surgeons approach aortic lesions. Although it was initially employed for patients who were poor surgical candidates, endovascular repair is now standard for abdominal aortic aneurysms and aneurysms in the descending thoracic aorta. Open surgery remains the gold standard for management of ascending aneurysms, in part due to the limitations portended by the anatomy of the ascending aorta, although increasing evidence suggests that endovascular approaches are feasible and may sometimes be optimal for patient outcomes. Here, we present some of the anatomical and technical challenges of the endovascular approach to these “Zone 0” aneurysms, the associated complications, and the current state of device development.
Diagnostic Value of lncRNA FGD5-AS1 Sponge miR-223-3p in Infantile Pneumonia and Its Prognostic Effect on Rehabilitation
Authors: Ren Hong-Ping , Wen Hong-Lin , Liu Ya-Nan , Cai Lin 
Published: November 2024

Abstract
Objective This study aimed to uncover the value of long noncoding RNA FGD5-AS1 (lncRNA FGD5-AS1) in the diagnosis of infantile pneumonia and explore its pathological mechanism in lung fibroblasts. This research may provide a potential biomarker for diagnosing patients and predicting their rehabilitation outcomes.
Methods This study included 92 children with infantile pneumonia as the research object, and an equal number of healthy children were introduced as controls. The FGD5-AS1 content was detected using real-time quantitative polymerase chain reaction (RT-qPCR) assay. The diagnostic value of FGD5-AS1 was evaluated by receiver operating characteristic (ROC) and logistic analysis. The molecular mechanism of FGD5-AS1 and miR-223-3p was studied by luciferase activity assays. The impact of abnormal FGD5-AS1 expression on the proliferation and apoptosis of lung fibroblasts was analyzed using the cell counting kit-8 (CCK-8) and flow cytometry.
Results FGD5-AS1 expression was decreased in the serum of infantile pneumonia patients, which may be a diagnostic marker for children with pneumonia. Furthermore, FGD5-AS1 has the ability to predict patient outcomes. FGD5-AS1 levels in lung fibroblasts (WI-38) decreased when induced by lipopolysaccharide (LPS). This decline resulted in reduced cell proliferation ability, increased apoptosis rate, and elevated inflammatory factor content. However, upregulated FGD5-AS1 counteracted the effects of LPS on WI-38 cells activity and inflammatory factors.
Conclusion FGD5-AS1 may act as a potential marker in infantile pneumonia, and regulate the biological activity and inflammation level of lung fibroblasts by targeting miR-223-3p.
Absolute Reference for Microwave Polarization Experiments. The COSMOCal Project and its Proof of Concept
Authors: Ritacco A. , Bizzarri L. , Savorgnano S. , Boulanger F. , Pérault M. , Treuttel J. , Morfin P. , Catalano A. , Darson D. , Ponthieu N. , Feret A. , Maffei B. , Chahadih A. , Pisano G. , Zannoni M. , Nati F. , Macías-Pérez J. F. , Cuttaia F. , Terenzi L. , Monfardini A. , Calvo M. , Murgia M. , Ortu P. , Pisanu T. , Aumont J. , Errard J. , Leclercq S. , Migliaccio M. 
Published: November 2024

Abstract

Context. The cosmic microwave background (CMB), a remnant of the Big Bang, provides unparalleled insights into the primordial universe, its energy content, and the origin of cosmic structures. The success of forthcoming terrestrial and space experiments hinges on meticulously calibrated data. Specifically, the ability to achieve an absolute calibration of the polarization angles with a precision of <0.°1 is crucial to identify the signatures of primordial gravitational waves and cosmic birefringence within the CMB polarization. Aims. We introduce the COSmological Microwave Observations Calibrator project, designed to deploy a polarized source in space for calibrating microwave frequency observations. The project aims to integrate microwave polarization observations from small and large telescopes, ground-based and in space, into a unified scale, enhancing the effectiveness of each observatory and allowing robust combination of data. Methods. To demonstrate the feasibility and confirm the observational approach of our project, we developed a prototype instrument that operates in the atmospheric window centered at 260 GHz, specifically tailored for use with the NIKA2 camera at the IRAM 30 m telescope. Results. We present the instrument components and their laboratory characterization. The results of tests performed with the fully assembled prototype using a Kinetic Inductance Detectors-based instrument, similar concept of NIKA2, are also reported. Conclusions. This study paves the way for an observing campaign using the IRAM 30 m telescope and contributes to the development of a space-based instrument.
Trade and Domestic Policies under Monopolistic Competition
Authors: Campolmi Alessia , Fadinger Harald , Forlati Chiara 
Published: November 2024

Abstract
Should trade agreements constrain domestic policies? We analyse this question using a model with monopolistic competition and constant-elasticity-of-substitution demand. We develop a welfare decomposition to show that welfare changes induced by trade and domestic policies can be decomposed into consumption and production efficiencies and terms-of-trade effects. We analyse the reasons to sign trade agreements and compare shallow and deep trade agreements, modelled according to GATT-WTO rules. Under monopolistic competition, unlike deep trade agreements, shallow agreements with market access commitments may not achieve efficiency because terms of trade can be improved without reducing market access by increasing the set of foreign firms selling domestically.
Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
Authors: Hernández-Lozano Irene , Aranzana-Climent Vincent , Cao Sha , Matias Carina , Ulf Hansen Jon , Liepinsh Edgars , Hughes Diarmaid , Hobbie Sven N , Vingsbo Lundberg Carina , Friberg Lena E 
Published: November 2024

Abstract

Objectives
The use of mouse models of complicated urinary tract infection (cUTI) has usually been limited to a single timepoint assessment of bacterial burden. Based on longitudinal in vitro and in vivo data, we developed a pharmacokinetic-pharmacodynamic (PKPD) model to assess the efficacy of apramycin, a broad-spectrum aminoglycoside antibiotic, in mouse models of cUTI.

Methods
Two Escherichia coli strains were studied (EN591 and ATCC 700336). Apramycin exposure–effect relationships were established with in vitro time–kill data at pH 6 and pH 7.4 and in mice with cUTI. Immunocompetent mice were treated with apramycin (1.5–30 mg/kg) starting 24 h post-infection. Kidney and bladder tissue were collected 6–96 h post-infection for cfu determination. A PKPD model integrating all data was developed and simulations were performed to predict bacterial burden in humans.

Results
Treatment with apramycin reduced the bacterial load in kidneys and bladder tissue up to 4.3-log compared with vehicle control. In vitro and in vivo tissue time-course efficacy data were integrated into the PKPD model, showing 76%–98% reduction of bacterial net growth and 3- to 145-fold increase in apramycin potency in vivo compared with in vitro. Simulations suggested that an 11 mg/kg daily dose would be sufficient to achieve bacterial stasis in kidneys and bladder in humans.

Conclusions
PKPD modelling with in vitro and in vivo PK and PD data enabled simultaneous evaluation of the different components that influence drug effect, an approach that had not yet been evaluated for antibiotics in the cUTI model and that has potential to enhance model-informed drug development of antibiotics.
Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: A Review Article
Authors: Edger-Lacoursière Zoë , Zhu Mengyue , Jean Stéphanie , Marois-Pagé Elisabeth , Nedelec Bernadette 
Published: November 2024

Abstract
Conservative management for hypertrophic scars (HSc) and scar contractures is of utmost importance to optimally reintegrate burn survivors into society. Many conservative treatment interventions have been described in the literature for the management of HSc. Recent advancements in the literature pertaining to postburn scarring and HSc formation have advanced our understanding of the mechanisms that support or refute the use of common rehabilitation treatment modalities after burn injury. This is particularly relevant for recent advancements in the fields of mechanotransduction and neurogenic inflammation, resulting in the need for rehabilitation clinicians to reflect upon commonly employed treatment interventions.
The aim of this review article is to summarize and clinically apply the evidence that supports or refutes the use of common conservative treatment interventions for scar management employed after burn injury. The following treatments are discussed, and mechanotransduction and neurogenic inflammation concepts are highlighted: (1) edema management (compression, positioning/elevation, pumping exercises, retrograde massage, and manual edema mobilization); (2) pressure therapy (including custom fabricated pressure garments, inserts, face masks, and other low-load long-duration orthotic devices); (3) gels or gel sheets; (4) combined pressure therapy and gels; (5) serial casting; (6) scar massage; and (7) passive stretching.
This review supports the following statements: (1) Compression for edema reduction should be initiated 48–72 hours postinjury and continued for wounds that require longer than 21 days to heal until scar maturation; (2) Elevation, pumping exercises, and retrograde massage/MEM should be used in combination with other edema management techniques; (3) Custom-fabricated pressure garments should be applied once the edema is stabilized and adequate healing has occurred. Garments should be monitored on a regular basis to ensure that optional pressure, &gt;15 mm Hg, is maintained, adding inserts when necessary. The wearing time should be &gt;16 hours/day; (4) Gels for postburn scar management should extend beyond the scar; (5) Serial casting should be applied when contractures interfere with function; (6) Forceful scar massage should be avoided early in the wound healing process or when the scar is inflamed or breaks down; and (7) Other treatment modalities should be prioritized over passive stretching for scar management.
The Limits of Formalism in the Separation of Powers
Authors: Roisman Shalev Gad 
Published: November 2024

Abstract
Formalism is the dominant mode of separation of powers analysis on the Supreme Court and one of two paradigmatic approaches in the academy. It seeks to resolve disputes between Congress and the President by asking which branch has exclusive power over the relevant matter. This method is thought to work because, if one branch has exclusive power over the matter, then, by definition, the other branch does not. Although this method is coherent and workable in some relatively straightforward cases, it is of no use in areas where both branches’ “exclusive” powers overlap—as formalists routinely concede is possible. This is a major problem because almost all the disputes that actually arise today involve areas of overlapping power. In such cases, both branches have relevant power to act and come into conflict. This Article argues that separation of powers formalism has never built—and can never build—a coherent method that tells us which branch to prioritize in such instances. These are the limits of formalism in the separation of powers. Formalism might help us understand some uncontroversial separation of powers questions, but it cannot resolve the disputes that actually matter today.
Factors related to acceptance of COVID-19 vaccine booster doses among patients with autoimmune and rheumatic diseases in Japan: A single-centre cross-sectional survey
Authors: Kurokawa Riki , Ohde Sachiko , Kawaai Satoshi , Tamaki Hiromichi 
Published: November 2024

ABSTRACT

Objectives
We studied the current state and factors associated with the acceptance or hesitancy of booster doses of the coronavirus disease 2019 (COVID-19) vaccine among patients with autoimmune and rheumatic diseases (ARDs) in Japan.

Methods
A single-centre cross-sectional survey was conducted among outpatients with ARDs who visited the Immuno-Rheumatology Center at St. Luke’s International Hospital from 1 October 2023 to 30 November 2023. We investigated patient characteristics, COVID-19 vaccination–related status, decision-making preferences, health-related status, and independent factors associated with the acceptance or hesitancy of booster doses of the COVID-19 vaccine.

Results
A total of 241 patients were included in the analyses, and 198 patients (82.2%) received booster doses, while 43 (17.8%) did not. Older age [adjusted odds ratio (aOR) = 0.43, 95% confidence interval (CI): 0.19, 0.95, P = .037], having rheumatoid arthritis (aOR = 0.41, 95% CI: 0.19, 0.92, P = .030), and having a physician recommend receiving the vaccine (aOR = 0.47, 95% CI: 0.23, 0.95, P = .035) were independently associated with receiving booster doses. The main reasons for hesitancy regarding booster doses were concerns about adverse reactions and long-term safety.

Conclusions
Our findings could help physicians counsel patients with ARDs regarding their acceptance of COVID-19 vaccine booster doses to promote appropriate decision-making.