bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Prehospital Thrombolysis in Stroke Patients With Prestroke Dependency
Authors: Nolte Christian H. , Ebinger Martin , Scheitz Jan F. , Kunz Alexander , Erdur Hebun , Geisler Frederik , Braemswig Tim Bastian , Rozanski Michal , Weber Joachim E. , Wendt Matthias , Zieschang Katja , Fiebach Jochen B. , Villringer Kersten , Grittner Ulrike , Kaczmarek Sabina , Endres Matthias , Audebert Heinrich J. 
Published: February 2018

Background and Purpose—
Data on effects of intravenous thrombolysis on outcome of patients with ischemic stroke who are dependent on assistance in activities of daily living prestroke are scarce. Recent registry based analyses in activities of daily –independent patients suggest that earlier start of intravenous thrombolysis in the prehospital setting leads to better outcomes when compared with the treatment start in hospital. We evaluated whether these observations can be corroborated in patients with prestroke dependency.

Methods—
This observational, retrospective analysis included all patients with acute ischemic stroke depending on assistance before stroke who received intravenous thrombolysis either on the Stroke Emergency Mobile (STEMO) or through conventional in-hospital care (CC) in a tertiary stroke center (Charité, Campus Benjamin Franklin, Berlin) during routine care. Prespecified outcomes were modified Rankin Scale scores of 0 to 3 and survival at 3 months, as well as symptomatic intracranial hemorrhage. Outcomes were adjusted in multivariable logistic regression.

Results—

Between February 2011 and March 2015, 122 of 427 patients (28%) treated on STEMO and 142 of 505 patients (28%) treated via CC needed assistance before stroke. Median onset-to-treatment times were 97 (interquartile range, 69–159; STEMO) and 135 (interquartile range, 98–184; CC;
P
<0.001) minutes. After 3 months, modified Rankin Scale scores of 0 to 3 was observed in 48 STEMO patients (39%) versus 35 CC patients (25%;
P
=0.01) and 86 (70%, STEMO) versus 85 (60%, CC) patients were alive (
P
=0.07). After adjustment, STEMO care was favorable with respect to modified Rankin Scale scores of 0 to 3 (odds ratio, 1.99; 95% confidence interval, 1.02–3.87;
P
=0.042) with a nonsignificant result for survival (odds ratio, 1.73; 95% confidence interval, 0.95–3.16;
P
=0.07). Symptomatic intracranial hemorrhage occurred in 5 STEMO versus 12 CC patients (4.2% versus 8.5%;
P
=0.167).

Conclusions—
The results of this study suggest that earlier, prehospital (as compared with in-hospital) start of intravenous thrombolysis in acute ischemic stroke may translate into better clinical outcome in patients with prestroke dependency.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02358772.
Hyperintense Vessels, Collateralization, and Functional Outcome in Patients With Stroke Receiving Endovascular Treatment
Authors: Nave Alexander H. , Kufner Anna , Bücke Philipp , Siebert Eberhard , Kliesch Stefan , Grittner Ulrike , Bäzner Hansjörg , Liebig Thomas , Endres Matthias , Fiebach Jochen B. , Nolte Christian H. , Ebinger Martin , Henkes Hans 
Published: February 2018

Background and Purpose—
Fluid-attenuated inversion recovery hyperintense vessels (FHV) are frequently observed on magnetic resonance imaging in acute stroke patients with proximal vessel occlusion. Whether FHV can serve as a surrogate for the collateral status and predict functional outcome of patients is still a matter of debate.

Methods—
Acute ischemic stroke patients with M1-middle cerebral artery occlusion who received magnetic resonance imaging before endovascular treatment in 3 hospitals in Germany between January 2007 and June 2016 were eligible. Quantification of FHV was performed using an FHV–Alberta Stroke Program Early CT Score (ASPECTS) rating system. Functional outcome was evaluated with the modified Rankin Scale 3 months after stroke. Collateral status of patients was graded on baseline angiography using the American Society of Interventional and Therapeutic Neuroradiology grading system. Odds for good outcome (modified Rankin Scale score, 0–2) were determined using logistic regression analyses.

Results—

Overall, 116 patients were analyzed (median age, 74; interquartile range [IQR], 64–79; median National Institutes of Health Stroke Scale, 14; IQR, 10–19). The median FHV-ASPECTS was 2 (IQR, 1–3). Good collateral status (American Society of Interventional and Therapeutic Neuroradiology grade 3–4) on angiography was more frequently observed in patients with FHV-ASPECTS ≤2 (83% versus 57%;
P
=0.025). Patients with an FHV-ASPECTS ≤2 had a better functional outcome after 3 months (median modified Rankin Scale score, 2; IQR, 0–5), compared with patients with an FHV-ASPECTS >2 (median modified Rankin Scale score, 4; IQR, 3–6;
P
=0.015). In multiple regression analyses, FHV-ASPECTS ≤2 was independently associated with good functional outcome (adjusted odds ratio, 5.3; 95% confidence interval, 1.5–18.2).

Conclusions—
Low FHV-ASPECTS is associated with both better collateral status and better 3-month functional outcome in acute stroke patients with M1 vessel occlusion.
Nomenclatural studies toward a World List of Diptera genus-group names. Part VI: Daniel William Coquillett
Authors: EVENHUIS NEAL L. 
Published: February 2018

The Diptera genus-group names of Daniel William Coquillett are reviewed and annotated. A total of 136 available genus-group names in 53 families of Diptera are listed alphabetically, and for each name giving author, year and page of original publication, originally included species, type species and method of fixation, current status of the name, family placement, and a list of any emendations of it that have been found in the literature. Remarks are given to clarify nomenclatural or taxonomic information. In addition, an index to all the species-group names of Diptera proposed by Coquillett (1,218, of which 1,214 are available names) is given with bibliographic reference (year and page) to each original citation. Appended to this study is a full bibliography of Coquillett’s published works. Name found to be unavailable: Philhelius Coquillett, 1910. Name found not to be preoccupied: Petia Coquillett, 1910 [Tachinidae]. Corrections to and clarifications of type species designations are made for the following: Isostomyia Coquillett, 1906 [Culicidae]; Micraedes Coquillett, 1906 [Culicidae]; Roederiodes Coquillett, 1901 [Empididae]; Stilbometopa Coquillett, 1899 [Hippoboscidae]; Tinolestes Coquillett, 1906 [Culicidae]. Previous First Reviser actions for multiple original spellings missed by previous workers include: Ateloglossa Coquillett, 1899 [Tachinidae]; Boreodromia Coquillett, 1903 [Brachystomatidae]; Mythicomyia Coquillett, 1893 [Mythicomyiidae]. The following are new synonymies of their respective senior synonyms: Acemyia Coquillett, 1897b under Acemya Robineau-Desvoidy, 1830, n. syn. [Tachinidae]; Clytiomyia Coquillett, 1897b under Clytiomya Rondani, 1861, n. syn. [Tachinidae]; Linnaemyia Coquillett, 1897b under Linnaemya Robineau-Desvoidy, 1830, n. syn. [Tachinidae]; Xanthogramma Schiner, 1860 under Philhelius Stephens, 1841, n. syn. [Syrphidae]. Using Reversal of Precedence (ICZN Code Art. 23.9), Scriptotricha Cockerell, 1889 [Tephritidae] is declared a nomen oblitum and Paracantha Coquillett, 1899f [Tephritidae] is declared a nomen protectum.
Climate Variability, Volcanic Forcing, and Last Millennium Hydroclimate Extremes
Authors: Stevenson Samantha , Overpeck Jonathan T. , Fasullo John , Coats Sloan , Parsons Luke , Otto-Bliesner Bette , Ault Toby , Loope Garrison , Cole Julia 
Published: February 2018

Abstract
Multidecadal hydroclimate variability has been expressed as “megadroughts” (dry periods more severe and prolonged than observed over the twentieth century) and corresponding “megapluvial” wet periods in many regions around the world. The risk of such events is strongly affected by modes of coupled atmosphere–ocean variability and by external impacts on climate. Accurately assessing the mechanisms for these interactions is difficult, since it requires large ensembles of millennial simulations as well as long proxy time series. Here, the Community Earth System Model (CESM) Last Millennium Ensemble is used to examine statistical associations among megaevents, coupled climate modes, and forcing from major volcanic eruptions. El Niño–Southern Oscillation (ENSO) strongly affects hydroclimate extremes: larger ENSO amplitude reduces megadrought risk and persistence in the southwestern United States, the Sahel, monsoon Asia, and Australia, with corresponding increases in Mexico and the Amazon. The Atlantic multidecadal oscillation (AMO) also alters megadrought risk, primarily in the Caribbean and the Amazon. Volcanic influences are felt primarily through enhancing AMO amplitude, as well as alterations in the structure of both ENSO and AMO teleconnections, which lead to differing manifestations of megadrought. These results indicate that characterizing hydroclimate variability requires an improved understanding of both volcanic climate impacts and variations in ENSO/AMO teleconnections.
An Assessment of High-Resolution Gridded Temperature Datasets over California
Authors: Walton Daniel , Hall Alex 
Published: February 2018

Abstract
High-resolution gridded datasets are in high demand because they are spatially complete and include important finescale details. Previous assessments have been limited to two to three gridded datasets or analyzed the datasets only at the station locations. Here, eight high-resolution gridded temperature datasets are assessed two ways: at the stations, by comparing with Global Historical Climatology Network–Daily data; and away from the stations, using physical principles. This assessment includes six station-based datasets, one interpolated reanalysis, and one dynamically downscaled reanalysis. California is used as a test domain because of its complex terrain and coastlines, features known to differentiate gridded datasets. As expected, climatologies of station-based datasets agree closely with station data. However, away from stations, spread in climatologies can exceed 6°C. Some station-based datasets are very likely biased near the coast and in complex terrain, due to inaccurate lapse rates. Many station-based datasets have large unphysical trends (&gt;1°C decade−1) due to unhomogenized or missing station data—an issue that has been fixed in some datasets by using homogenization algorithms. Meanwhile, reanalysis-based gridded datasets have systematic biases relative to station data. Dynamically downscaled reanalysis has smaller biases than interpolated reanalysis, and has more realistic variability and trends. Dynamical downscaling also captures snow–albedo feedback, which station-based datasets miss. Overall, these results indicate that 1) gridded dataset choice can be a substantial source of uncertainty, and 2) some datasets are better suited for certain applications.
Development of an operational manual for a consultation–liaison psychiatry service
Authors: Wand Anne PF , Sharma Swapnil , Carpenter Lindsay J , Gatsi Mike 
Published: February 2018

Objectives: Consultation–liaison psychiatry (CLP) services sit between mental health and the general hospital, and risk being poorly understood by both systems. The aim of this study was to develop an operational manual for a CLP service, which defined functions and governance. Methods: The CLP literature was reviewed with a focus on descriptions of CLP roles, organisational processes, quality measures and service development. The CLP team held service planning meetings and met with members of the mental health and hospital executives. Site visits and collaboration with other CLP services occurred in defining the roles of the CLP service and organisational governance. Results: A CLP operational document was developed, including a description of the service, its functions, staff roles and governance. Procedural information such as the CLP timetable, referral process, triage and assessment, documentation, activity recording, quality assurance and relevant policies were outlined. Conclusions: The development of a dedicated operational manual for CLP clarified the roles, functions and governance of CLP within the general hospital and mental health systems. The development process facilitated the engagement of key clinicians and administrators of these systems, the determination of quality improvement targets and greater transparency and accountability.
Civil forensic psychiatry – Part 2: specific issues
Authors: Samuels Anthony H 
Published: February 2018

Objectives: This paper describes the main areas of civil forensic psychiatry (FP) and the skills required by psychiatric experts. Some specific areas of civil FP are discussed, including tort law reform, reliability of psychiatric evidence, contentious psychiatric disorders, and the many domains of civil FP. Conclusions: Civil FP is an important sub-specialty component of forensic psychiatry that requires greater emphasis in the training and continuing education of psychiatrists. A process of accrediting psychiatrists as having competency in advanced civil FP may be of value.
Evaluation of a Community Development Program in Nepal
Authors: Hong Ijin , Roh Kyung-hoo 
Published: February 2018

Objective: This study aims to evaluate the impact of a community development program meant to improve living standards of poor rural families through income generating activities (IGAs) based on conditional cash transfers (CCTs) in Doti, Nepal. Method: We use cross-sectional field data from a sample of 392 families representative of the village development committees of Pokhari, Ladagada, and Gajari. After running a propensity score analysis to increase comparability between the treatment and comparison groups, we compare mean scores on a series of chosen outcome variables via t-test analyses. Results: Results suggest that, although improvements in family income and living standards are felt subjectively, crop production might have worsened as a result of IGAs, suggesting the possibility of a trade-off and of long-term effects. Discussion and Implications: This article has implications for research and practice in community development programs and data collection and evaluation of such programs.
Sensitivity of the Saline Load Test for Traumatic Arthrotomy of the Ankle With Ankle Arthroscopy Simulation
Authors: Bohl Daniel D. , Frank Rachel M. , Lee Simon , Hamid Kamran S. , Holmes George B. , Lin Johnny , Lee Simon 
Published: February 2018

Background: The saline load test has been used to evaluate for traumatic arthrotomy in orthopedics. The purpose of this study was to determine the volume of saline required to detect traumatic arthrotomy of the ankle. Methods: Forty-two patients undergoing elective ankle arthroscopy were prospectively enrolled. For each patient, a standard 4-mm anteromedial portal was established. Next, an 18-gauge needle was inserted at the site of the anterolateral portal. Sterile saline was slowly injected through the needle until saline extravasated from the anteromedial portal. Saline volumes at the time of extravasation were recorded and analyzed. Results: The saline volume required to achieve extravasation ranged from 0.2 to 60.0 mL. The median saline volume required to achieve extravasation was 9.7 mL (interquartile range, 3.8–29.6 mL); however, 5 of 42 patients required volumes between 50.0 and 60.0 mL. A total of 50.0 mL was required to achieve 90% sensitivity, 55.0 mL to achieve 95% sensitivity, and 60.0 mL to achieve 99% sensitivity. Conclusions: The previously recommended 30 mL of saline required to reliably detect traumatic arthrotomy of the ankle may be too small a volume. Clinical Relevance: The present study suggests that clinicians should attempt to inject 60 mL of saline to effectively rule out a traumatic arthrotomy injury. Because of the study’s methods involving an anteromedial arthrotomy with anterolateral saline injection, these findings may be most valid for arthrotomies on the medial side of the ankle.
Predicting 30-day mortality in patients with sepsis: An exploratory analysis of process of care and patient characteristics
Authors: Sanderson Miriam , Chikhani Marc , Blyth Esme , Wood Sally , Moppett Iain K , McKeever Tricia , Simmonds Mark JR 
Published: February 2018

Background Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients with sepsis in Nottingham. Methods Data were collected prospectively from adult patients with sepsis in Nottingham University Hospitals NHS Trust as part of an on-going quality improvement project between November 2011 and March 2014. Patients admitted to critical care with the diagnosis of sepsis were included in the study. In all, 97 separate variables were investigated for their association with 30-day mortality. Variables included patient demographics, symptoms of systemic inflammatory response syndrome, organ dysfunction or tissue hypoperfusion, locations of early care, source of sepsis and time to interventions. Results A total of 455 patients were included in the study. Increased age (adjOR = 1.05 95%CI = 1.03–1.07 p < 0.001), thrombocytopenia (adjOR = 3.10 95%CI = 1.23–7.82 p = 0.016), hospital-acquired sepsis (adjOR = 3.34 95%CI = 1.78–6.27 p < 0.001), increased lactate concentration (adjOR = 1.16 95%CI = 1.06–1.27 p = 0.001), remaining hypotensive after vasopressors (adjOR = 3.89 95%CI = 1.26–11.95 p = 0.02) and mottling (adjOR = 3.80 95%CI = 1.06–13.55 p = 0.04) increased 30-day mortality odds. Conversely, fever (adjOR = 0.46 95%CI = 0.28-0.75 p = 0.002), fluid refractory hypotension (adjOR = 0.29 95%CI = 0.10–0.87 p = 0.027) and being diagnosed in surgical wards (adjOR = 0.35 95%CI = 0.15–0.81 p = 0.015) were protective. Treatment timeliness were not significant factors. Conclusion Several important predictors of 30-day mortality were found by this research. Retrospective analysis of our sepsis data has revealed mortality predictors that appear to be more patient-related than intervention-specific. With this information, care can be improved for those identified most at risk of death.
Extranodal non-B, non-T-cell lymphoma with bilateral tympanic bulla involvement in a cat
Authors: Kerns Austin T , Brakel Kelsey A , Premanandan Christopher , Saffire Ashlie , Moore Sarah A 
Published: February 2018

Case summary A 9-year-old spayed female domestic shorthair cat with clinical signs suggestive of chronic recurrent otitis media and recent seizures was presented with multifocal nervous system disease, including bilateral central and/or peripheral vestibular, cerebellar and forebrain deficits. Prior to presentation, there was inadequate improvement after 6 weeks of treatment for bilateral middle ear effusion from which a highly susceptible Staphylococcus species was cultured. This was followed by the development of seizures. Results of a complete blood count and serum chemistry were unremarkable, and a previous feline leukemia virus/feline immunodeficiency virus ELISA was negative. The cat was hospitalized overnight and had multiple seizures. The following morning the cat’s mentation worsened, and the cat lost ventilatory drive after induction for anesthesia in preparation for MRI. A brain herniation event was suspected, and the cat was euthanized prior to further diagnostics. On post-mortem examination both tympanic bullae were filled with a soft, tan-colored material. Histologically, this material was composed of neoplastic lymphocytes. In addition, neoplastic lymphocytes were found in the leptomeninges, brain parenchyma, submandibular lymph nodes and pancreas. The neoplastic lymphocytes were negative for both B- and T-lymphocyte immunohistochemical markers and PCR for antigen receptor rearrangements failed to amplify target DNA, indicating non-B, non-T-cell lymphoma. Relevance and novel information To our knowledge, this is the first report of lymphoma with confirmed bilateral tympanic bulla involvement in the human and veterinary literature. Neoplasia should be considered in cases of middle-ear effusion that do not improve adequately with appropriate antimicrobial therapy.
Functional outcome of open surgical A1 pulley release in diabetic and nondiabetic patients
Authors: Ashour A , Alfattni A , Hamdi A 
Published: February 2018

Purpose: Trigger finger, also referred to as stenotic flexor tenosynovitis, is a common condition affecting the digits, with a lifetime incidence of 2.6% among the healthy population and up to 16.5% in diabetic patients. Diabetes mellitus is associated with multiple musculoskeletal conditions including trigger finger. In this study, we aimed to compare the functional outcome of trigger finger release in diabetic and nondiabetic patients to evaluate whether the management of trigger finger in diabetic patients should be the same as that in nondiabetic patients, or whether diabetic patients would benefit from a more tailored management plan to optimize results. Methods: A retrospective case–control study was performed at a single center among patients who underwent A1 pulley release from January 2013 to February 2017. Patients were diagnosed with trigger finger grades I to IV according to the Quinnell classification and assessed using the The Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire (Arabic version). Results: Sixty-nine patients, including 21 male (30.4%) and 48 female (69.6%), underwent A1 pulley release surgery. More than half of the participants included in this study were diabetic (n = 40, 58%) and 29 were nondiabetic (42%). The mean postoperative QuickDASH scores were 19.93 among diabetic patients and 17.15 among nondiabetic patients. There was no significant difference in the functional outcome between diabetic and nondiabetic ( p = 0.6) patients. Conclusions: The postoperative functional outcomes are similar in diabetic and nondiabetic patients. Therefore, the management of trigger finger should be the same in both groups.
Hydrothermal Synthesis of Hollow Al2O3 Microfibers for Thermal Insulation Materials
Authors: Yamashita Hiroki , Ogami Takaaki , Kanamura Kiyoshi 
Published: February 2018

Abstract
Hollow Al2O3 microfibers were successfully synthesized via a novel hydrothermal method using cotton fiber as a template followed by annealing. The hollow Al2O3 microfibers annealed at 1200 °C for 5 h contained no impurity phases, and the Al2O3 composing the microfibers was confirmed to exhibit the trigonal unit cell of α-Al2O3 with R$\bar{3}$c space-group symmetry. The synthesized hollow Al2O3 microfibers were 5–15 µm in diameter, with walls 500–800 nm thick; the walls were composed of Al2O3 primary particles 100–200 nm in diameter. The specific heat capacity of the synthesized hollow Al2O3 microfibers was approximately the same as that reported in the literature for α-Al2O3. In addition, the annealing temperature of the hollow Al2O3 microfibers was studied to elucidate their mechanism of formation. The chemical and physical properties of the synthesized hollow Al2O3 microfibers indicate that they can be used as a thermal insulation material.