bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
Authors: Pizzagalli Diego Ulisse , Farsakoglu Yagmur , Palomino-Segura Miguel , Palladino Elisa , Sintes Jordi , Marangoni Francesco , Mempel Thorsten R. , Koh Wan Hon , Murooka Thomas T. , Thelen Flavian , Stein Jens V. , Pozzi Giuseppe , Thelen Marcus , Krause Rolf , Gonzalez Santiago Fernandez 
Published: July 2018

AbstractRecent advances in intravital video microscopy have allowed the visualization of leukocyte behavior in vivo, revealing unprecedented spatiotemporal dynamics of immune cell interaction. However, state-of-the-art software and methods for automatically measuring cell migration exhibit limitations in tracking the position of leukocytes over time. Challenges arise both from the complex migration patterns of these cells and from the experimental artifacts introduced during image acquisition. Additionally, the development of novel tracking tools is hampered by the lack of a sound ground truth for algorithm validation and benchmarking. Therefore, the objective of this work was to create a database, namely LTDB, with a significant number of manually tracked leukocytes. Broad experimental conditions, sites of imaging, types of immune cells and challenging case studies were included to foster the development of robust computer vision techniques for imaging-based immunological research. Lastly, LTDB represents a step towards the unravelling of biological mechanisms by video data mining in systems biology.
Systematic, continental scale temporal monitoring of marine pelagic microbiota by the Australian Marine Microbial Biodiversity Initiative
Authors: Brown Mark V. , van de Kamp Jodie , Ostrowski Martin , Seymour Justin R. , Ingleton Tim , Messer Lauren F. , Jeffries Thomas , Siboni Nahshon , Laverock Bonnie , Bibiloni-Isaksson Jaume , Nelson Tiffanie M. , Coman Frank , Davies Claire H. , Frampton Dion , Rayner Mark , Goossen Kirianne , Robert Stan , Holmes Bronwyn , Abell Guy C.J. , Craw Pascal , Kahlke Tim , Sow Swan Li San , McAllister Kirsty , Windsor Jonathan , Skuza Michele , Crossing Ryan , Patten Nicole , Malthouse Paul , van Ruth Paul D. , Paulsen Ian , Fuhrman Jed A. , Richardson Anthony , Koval Jason , Bissett Andrew , Fitzgerald Anna , Moltmann Tim , Bodrossy Levente 
Published: July 2018

AbstractSustained observations of microbial dynamics are rare, especially in southern hemisphere waters. The Australian Marine Microbial Biodiversity Initiative (AMMBI) provides methodologically standardized, continental scale, temporal phylogenetic amplicon sequencing data describing Bacteria, Archaea and microbial Eukarya assemblages. Sequence data is linked to extensive physical, biological and chemical oceanographic contextual information. Samples are collected monthly to seasonally from multiple depths at seven sites: Darwin Harbour (Northern Territory), Yongala (Queensland), North Stradbroke Island (Queensland), Port Hacking (New South Wales), Maria Island (Tasmania), Kangaroo Island (South Australia), Rottnest Island (Western Australia). These sites span ~30° of latitude and ~38° longitude, range from tropical to cold temperate zones, and are influenced by both local and globally significant oceanographic and climatic features. All sequence datasets are provided in both raw and processed fashion. Currently 952 samples are publically available for bacteria and archaea which include 88,951,761 bacterial (72,435 unique) and 70,463,079 archaeal (24,205 unique) 16 S rRNA v1-3 gene sequences, and 388 samples are available for eukaryotes which include 39,801,050 (78,463 unique) 18 S rRNA v4 gene sequences.
A Gaia DR2 view of the open cluster population in the Milky Way
Authors: Cantat-Gaudin T. , Jordi C. , Vallenari A. , Bragaglia A. , Balaguer-Núñez L. , Soubiran C. , Bossini D. , Moitinho A. , Castro-Ginard A. , Krone-Martins A. , Casamiquela L. , Sordo R. , Carrera R. 
Published: July 2018

Context. Open clusters are convenient probes of the structure and history of the Galactic disk. They are also fundamental to stellar evolution studies. The second Gaia data release contains precise astrometry at the submilliarcsecond level and homogeneous photometry at the mmag level, that can be used to characterise a large number of clusters over the entire sky.
Aims. In this study we aim to establish a list of members and derive mean parameters, in particular distances, for as many clusters as possible, making use of Gaia data alone.
Methods. We compiled a list of thousands of known or putative clusters from the literature. We then applied an unsupervised membership assignment code, UPMASK, to the Gaia DR2 data contained within the fields of those clusters.
Results. We obtained a list of members and cluster parameters for 1229 clusters. As expected, the youngest clusters are seen to be tightly distributed near the Galactic plane and to trace the spiral arms of the Milky Way, while older objects are more uniformly distributed, deviate further from the plane, and tend to be located at larger Galactocentric distances. Thanks to the quality of Gaia DR2 astrometry, the fully homogeneous parameters derived in this study are the most precise to date. Furthermore, we report on the serendipitous discovery of 60 new open clusters in the fields analysed during this study.
Effects of movement velocity and training frequency of resistance exercise on functional performance in older adults: a randomised controlled trial
Authors: Richardson Darren L. , Duncan Michael J. , Jimenez Alfonso , Juris Paul M. , Clarke Neil D. 
Published: July 2018

AbstractObjectives: To investigate the effects that high‐velocity, low‐load (HVLL) and low‐velocity, high‐load (LVHL) resistance exercise, performed once or twice‐weekly, have on indices of functional performance (primary outcome), maximal strength, and body composition (secondary outcomes) in older adults.Methods: In a randomised, controlled, multi‐armed, parallel design, 54 moderately‐highly active, but resistance exercise naïve older adults (aged 60–79 years), attended baseline and post‐10‐week intervention assessment sessions. Physical and functional assessments were completed, and predicted one‐repetition maximums (1‐RM) were obtained for eight exercises. Participants were then randomised into one of five conditions: HVLL once‐weekly (HVLL1: n = 11) or twice‐weekly (HVLL2: n = 11), LVHL once‐weekly (LVHL1: n = 10) or twice‐weekly (LVHL2: n = 11), no‐exercise control condition (CON: n = 11). The HVLL conditions completed 3 sets of 14 repetitions at 40% 1‐RM and the LVHL conditions, 3 sets of 7 repetitions at 80% 1‐RM. In total, 50 participants completed all testing and were included in analyses.Results: Only LVHL2 improved 30‐sec chair stand performance (p = .035; g = 0.89), arm curls (p = .011; g = 1.65) and grip‐strength (p = .015; g = 0.34) compared to CON. LVHL2 improved maximal strength compared to CON for 7/8 exercises (p < .05). Whereas, LVHL1 and HVLL2 only improved seated row and chest press compared to CON (p < .05).Conclusion: Possibly due to the lower intensity nature of the HVLL conditions, LVHL, twice‐weekly was most beneficial for improving functional performance and strength in moderately‐highly active older adults. Therefore, we recommend that exercise professionals ensure resistance exercise sessions have sufficient intensity of effort and volume, in order to maximise functional performance and strength gains in older adults.
Explanatory Relevance and Contrastive Explanation
Authors: Pincock Christopher 
Published: July 2018

AbstractA pluralist about explanation posits many explanatory relevance relations, while an invariantist denies any substantial role for context in fixing genuine explanation. This article summarizes one approach to combining pluralism and invariantism that emphasizes the contrastive nature of explanation. If explanations always take contrasts as their objects and contrasts come in types, then the role for the context in which an explanation is given can be minimized. This approach is illustrated using a classic debate between natural theology and natural selection about the structure of bees’ honeycombs.
Medication-related quality of care in residential aged care: an Australian experience
Authors: Hillen Jodie B , Vitry Agnes , Caughey Gillian E 
Published: July 2018

Abstract

Objective
To describe medication-related quality of care (MRQOC) for Australian aged care residents.

Design
Retrospective cohort using an administrative healthcare claims database.

Setting
Australian residential aged care.

Participants
A total of 17 672 aged care residents who were alive at 1 January 2013 and had been a permanent resident for at least 3 months.

Main outcome measures
Overall, 23 evidence-based MRQOC indicators which assessed the use of appropriate medications in chronic disease, exposure to high-risk medications and access to collaborative health services.

Results
Key findings included underuse of recommended cardiovascular medications, such as the use of statins in cardiovascular disease (56.1%). Overuse of high-risk medications was detected for medications associated with falls (73.5%), medications with moderate to strong anticholinergic properties (46.1%), benzodiazepines (41.4%) and antipsychotics (33.2%). Collaborative health services such as medication reviews were underutilised (42.6%).

Conclusion
MRQOC activities in this population should be targeted at monitoring and reducing exposure to antipsychotics and benzodiazepines, improving the use of preventative medications for cardiovascular disease and improving access to collaborative health services. Similarity of suboptimal MRQOC between Australia and other countries (UK, USA, Canada and Belgium) presents an opportunity for an internationally collaborative approach to improving care for aged care residents.
BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages
Authors: Zhou Tong , Xie Xueying , Li Musheng , Shi Junchao , Zhou Jin J. , Knox Kenneth S. , Wang Ting , Chen Qi , Gu Wanjun 
Published: July 2018

SummaryCircular RNAs (circRNAs) are a novel class of regulatory RNAs. Here, we present a comprehensive investigation of circRNA expression profiles across 11 tissues and 4 developmental stages in rats, along with cross-species analyses in humans and mice. Although positively correlated, circRNAs exhibit higher tissue specificity than cognate mRNAs. Also, genes with higher expression levels exhibit a larger fraction of spliced circular transcripts than their linear counterparts. Intriguingly, while we observed a monotonic increase of circRNA abundance with age in the rat brain, we further discovered a dynamic, age-dependent pattern of circRNA expression in the testes that is characterized by a dramatic increase with advancing stages of sexual maturity and a decrease with aging. The age-sensitive testicular circRNAs are highly associated with spermatogenesis, independent of cognate mRNA expression. The tissue/age implications of circRNAs suggest that they present unique physiological functions rather than simply occurring as occasional by-products of gene transcription.
Sleep selectively stabilizes contextual aspects of negative memories
Authors: Cox Roy , van Bronkhorst Marthe LV , Bayda Mollie , Gomillion Herron , Cho Eileen , Parr Elaine , Manickas-Hill Olivia P , Schapiro Anna C , Stickgold Robert 
Published: July 2018

AbstractSleep and emotion are both powerful modulators of the long-term stability of episodic memories, but precisely how these factors interact remains unresolved. We assessed changes in item recognition, contextual memory, and affective tone for negative and neutral memories across a 12 h interval containing sleep or wakefulness in 71 human volunteers. Our data indicate a sleep-dependent stabilization of negative contextual memories, in a way not seen for neutral memories, item recognition, or across wakefulness. Furthermore, retention of contextual memories was positively associated with time spent in non-rapid eye movement sleep. Finally, our results offer partial support for the hypothesis that sleep attenuates emotional responses to previously memorized material.
A Comprehensive Approach Characterizing Fusion Proteins and Their Interactions Using Biomedical Literature
Authors: Tagore Somnath , Gorohovski Alessandro , Jensen Lars Juhl , Frenkel-Morgenstern Milana 
Published: July 2018

AbstractToday’s increase in scientific literature requires the efficient methods of data mining for improving the extraction of the useful information from texts. In this manuscript, we used a data and text mining method to identify fusions and their protein-protein interactions from published biomedical text. The extracted fusion proteins and their protein-protein interactions are used as a training set for a Naïve Bayes classifier that is further used for final identification of testing dataset, consisting of 1817 fusions. Our method has a literature corpus, text and annotation mappers; keywords, rule bases, negative tokens, and pattern extractor; synonym tagger, normalization, regular expression mapper; and Naïve Bayes classifier. We classified 1817 unique fusion proteins and their corresponding 2908 protein-protein interactions for 18 cancer types. Therefore, it can be used for screening literature for identifying mentions unique cases of fusions that can be further used for downstream analysis. It is available athttp://protfus.md.biu.ac.il/.
The palmitoyl acyltransferase DHHC5 mediates beta-adrenergic signaling in the heart by targeting Gα proteins and G protein-coupled receptor kinase 2
Authors: Chen Jessica J. , Marsden Autumn N. , Akimzhanov Askar M. , Boehning Darren 
Published: July 2018

AbstractS-palmitoylation is a reversible posttranslational modification that plays an important role in regulating protein localization, trafficking, and stability. Recent studies have shown that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles after cellular stimulation supporting a direct signaling role for this posttranslational modification. Here we investigated whether β-adrenergic stimulation of cardiomyocytes led to stimulus-dependent palmitoylation of downstream signaling proteins. We found that β-adrenergic stimulation led to increased Gαs and Gαi palmitoylation. The kinetics of palmitoylation was temporally consistent with the downstream production of cAMP and positive inotropic responses. Additionally, we identified for the first time that G protein-coupled receptor kinase 2 (GRK2) is a palmitoylated protein in cardiomyocytes. The kinetics of GRK2 palmitoylation were distinct from those observed with Gαs and Gαi after β-adrenergic stimulation. Knockdown of the plasma membrane-localized palmitoyl acyltransferase DHHC5 revealed that this enzyme is necessary for palmitoylation of Gαs, Gαi, and GRK2 and functional responses downstream of β-adrenergic stimulation. Our results reveal that DHHC5 activity is required for signaling downstream of β-adrenergic receptors.
Corporate food donations: altruism, strategy or cost saving?
Authors: Sert Sedef , Garrone Paola , Melacini Marco , Perego Alessandro 
Published: July 2018

PurposeThe purpose of this paper is to enhance the understanding of motives behind corporate giving and at finding out whether and when operational efficiency plays a major role in the case of surplus food donations by food supply chain companies.Design/methodology/approachA multiple case study methodology has been applied considering a sample of 16 food sector companies operating in Italy. Three cases have been analyzed in-depth to highlight the contextual factors that make cost savings possible and donations sizeable and regular.FindingsThe results show that the willingness of companies to reduce operational costs plays a relevant role in managerial decisions concerning the recovery and donation of unsold food, although to different degrees across the supply chain stages.Originality/valueThe paper shows that not only strategic and moral motives, but also economic efficiency concern plays an important role in the managerial decision-making process pertaining to surplus food donations.
Making sense of team integration practice through the “lived experience” of alliance project teams
Authors: Che Ibrahim Che Khairil Izam , Costello Seosamh B. , Wilkinson S. 
Published: July 2018

Purpose
Team integration is a concept that has been widely fostered in alliances as a way of improving collaborative relationships between diverse organisations. However, deeper insights into the practice of high levels of team integration remain elusive. The purpose of this paper is to develop a deeper understanding of team integration through the “lived experience” of practitioners in an alliance.

Design/methodology/approach
This study employed a qualitative research methodology. Using a phenomenological examination, via the lived experiences of 24 alliance practitioners, the practice of alliance team integration has been investigated based on the key indicators that foster alliance team integration: team leadership, trust and respect, single team focus on project objectives and key results areas, collective understanding, commitment from project alliance board, single and co-located alliance team, and free flow communication.

Findings
The findings highlight that alliancing gives the project teams’ flexibility to change and adapt, to advance the collaborative environment and that successful integration of multi-disciplinary project teams requires commitment to the identified indicators. These findings have led to the development of a framework of leadership for successful alliance integrated practices. It is proposed that to influence the leadership for the purpose of achieving successful integration practice, a team-centric approach is required which includes four elements: task and relationship-oriented behaviours; collaborative learning environments; cultivating cross-boundary networks; and collaborative governance.

Practical implications
As team integration is the central tenet of alliance projects, greater understanding regarding the leadership of integration practice is of value in leveraging the benefits of outstanding performance. Also, the results of the study are expected to be informative and provide insight for alliance teams to help them proactively recognise how the context of integrated teams is influenced by specific indicators, impacting on the extent of integration practice.

Originality/value
This study contributes to the current body of knowledge concerning the insights from the “lived experience” of alliance teams towards achieving a greater understanding of what contributes to the leadership of successful integration practices.
Exploring the role of intellectual capital in supply chain intelligence integration
Authors: Shou Yongyi , Hu Wenjin , Xu Yongmei 
Published: July 2018

PurposeThe purpose of this paper is to explore the role of intellectual capital (IC) in supply chain intelligence integration (SCII) and the interrelationships of the three components of IC (i.e. human capital (HC), structural capital (SC) and relational capital (RC)) in the supply chain context.Design/methodology/approachThis paper conducted an empirical study by using primary data from 389 sample firms. The authors applied structural equation modeling to test the proposed hypotheses.FindingsThe results indicate that both HC and RC have direct impact on SCII, whereas SC only influences SCII through RC.Originality/valueThis study evidences that IC is an enabler of SCII. Furthermore, this study reveals the interrelationships of human, structural and RC.
Signaling theory and the determinants of online financial disclosure
Authors: Musleh Al-Sartawi Abdalmuttaleb , Reyad Sameh 
Published: July 2018

Purpose
The purpose of this paper is to examine and report on the extent and firm characteristics that determine the practices of online financial disclosure (OFD) by the Islamic banks in the Gulf Cooperation Council (GCC) countries.

Design/methodology/approach
Data were collected using the websites of 48 Islamic banks listed on the stock markets in the GCC countries. Moreover, the study used the websites of the stock markets to get more financial information which was not found on the websites of the banks. The study covered a period of three years from 2015 to 2017. A checklist was used to compute the total level of OFD.

Findings
This study found that the overall level of OFD in the GCC by Islamic banks is 72.4 percent. The results also report a significant and positive relationship with firm size. On the other hand, the results show an insignificant relationship with profitability (ROE and ROA), leverage and age.

Practical implications
The paper provides awareness regarding OFD that might prove beneficial to the various stakeholders of the banks including investors, regulators and preparers of financial statements.

Originality/value
This paper is an important contribution to filling the gap in the literature, as there are a negligible number of studies dealing with OFD from an Islamic perspective.
The effects of an educational program on knowledge, attitudes and intentions regarding condom and emergency contraceptive pill use among Thai female university students
Authors: Thongnopakun Saowanee , Pumpaibool Tepanata , Somrongthong Ratana 
Published: July 2018

Purpose
University students who have low knowledge, attitudes and intentions regarding the prevention of unintended pregnancies may experience higher rates of unintended pregnancies. An educational program was developed based on the self-efficacy theory and peer-led education to improve unintended pregnancy problems among university students. The purpose of this paper is to examine the effect of an educational program on knowledge, attitudes and intentions regarding the use of condoms and emergency contraceptive pills among Thai university students.

Design/methodology/approach
The effectiveness of the educational program was tested by a quasi-experimental study with a pre- and post-test design. The study was conducted between September and October 2017. Multistage sampling was used to recruit 73 Thai female university students, including 36 students in the intervention group and 37 students in the comparison group. The intervention group received an eight-week educational program, while the comparison group did not. A self-administered questionnaire was used to assess the improvement of knowledge, attitudes and intention regarding condom and emergency contraceptive pill use. Descriptive statistics, paired samples t-test, Wilcoxon test and Mann–Whitney tests were used for data analysis.

Findings
Most participants in both groups had sexual intercourse. After the end of the program, the before-after mean score of the intervention group’s knowledge (8.0, 11.0), attitudes (29.4, 32.4) and intention (17.4, 20.4) were significantly increased (p-value<0.001). Post-intervention, there were statistically significant differences in knowledge scores (p-value<0.001) and intention scores (p-value=0.04) between the intervention group and the comparison group.

Originality/value
This educational program increases knowledge and intention but does not influence attitudes toward using condoms and emergency contraceptive pills.