bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicted Effectiveness of Daily and Nondaily Preexposure Prophylaxis for Men Who Have Sex With Men Based on Sex and Pill-taking Patterns From the Human Immuno Virus Prevention Trials Network 067/ADAPT Study
Authors: Dimitrov Dobromir , Moore James R , Wood Daniel , Mitchell Kate M , Li Maoji , Hughes James P , Donnell Deborah J , Mannheimer Sharon , Holtz Timothy H , Grant Robert M , Boily Marie-Claude 
Published: August 2019

Abstract

Background
The HIV Prevention Trials Network (HPTN) 067/Alternative Dosing to Augment PrEP Pill Taking (ADAPT) Study evaluated the feasibility of daily and nondaily human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) regimens among high-risk populations, including men who have sex with men (MSM) and transgender women, in Bangkok, Thailand and Harlem, New York. We used a mathematical model to predict the efficacy and effectiveness of different dosing regimens.

Methods
An individual-based mathematical model was used to simulate annual HIV incidence among MSM cohorts. PrEP efficacy for covered sex acts, as defined in the HPTN 067/ADAPT protocol, was estimated using subgroup efficacy estimates from the preexposure prophylaxis initiative (iPrEx) trial. Effectiveness was estimated by comparison of the HIV incidence with and without PrEP use.

Results
We estimated that PrEP was highly protective (85%–96% efficacy across regimens and sites) for fully covered acts. PrEP was more protective for partially covered acts in Bangkok (71%–88% efficacy) than in Harlem (62%–81% efficacy). Our model projects 80%, 62%, and 68% effectiveness of daily, time-driven, and event-driven PrEP for MSM in Harlem compared with 90%, 85%, and 79% for MSM in Bangkok. Halving the efficacy for partially covered acts decreases effectiveness by 8–9 percentage points in Harlem and by 5–9 percentage points in Bangkok across regimens.

Conclusions
Our analysis suggests that PrEP was more effective among MSM in Thailand than in the United States as a result of more fully covered sex acts and more pills taken around partially covered acts. Overall, nondaily PrEP was less effective than daily PrEP, especially in the United States where the sex act coverage associated with daily use was substantially higher.
Lessons From Influenza Pandemics of the Last 100 Years
Authors: Monto Arnold S , Fukuda Keiji 
Published: August 2019

Abstract
Seasonal influenza is an annual occurrence, but it is the threat of pandemics that produces universal concern. Recurring reports of avian influenza viruses severely affecting humans have served as constant reminders of the potential for another pandemic. Review of features of the 1918 influenza pandemic and subsequent ones helps in identifying areas where attention in planning is critical. Key among such issues are likely risk groups and which interventions to employ. Past pandemics have repeatedly underscored, for example, the vulnerability of groups such as pregnant women and taught other lessons valuable for future preparedness. While a fundamental difficulty in planning for the next pandemic remains their unpredictability and infrequency, this uncertainty can be mitigated, in part, by optimizing the handling of the much more predictable occurrence of seasonal influenza. Improvements in antivirals and novel vaccine formulations are critical in lessening the impact of both pandemic and seasonal influenza.
Information Propagation and Public Opinion Evolution Model Based on Artificial Neural Network in Online Social Network
Authors: Liu Xiaoyang , He Daobing 
Published: August 2019

Abstract
This paper proposes a new information dissemination and opinion evolution IPNN (Information Propagation Neural Network) model based on artificial neural network. The feedforward network, feedback network and dynamic evolution algorithms are designed and implemented. Firstly, according to the ‘six degrees separation’ theory of information dissemination, a seven-layer neural network underlying framework with input layer, propagation layer and termination layer is constructed; secondly, the information sharing and information interaction evolution process between nodes are described by using the event information forward propagation algorithm, opinion difference reverse propagation algorithm; finally, the external factors of online social network information dissemination is considered, the impact of external behavior patterns is measured by media public opinion guidance and network structure dynamic update operations. Simulation results show that the proposed new mathematical model reveals the relationship between the state of micro-network nodes and the evolution of macro-network public opinion. It accurately depicts the internal information interaction mechanism and diffusion mechanism in online social network. Furthermore, it reveals the process of network public opinion formation and the nature of public opinion explosion in online social network. It provides a new scientific method and research approach for the study of social network public opinion evolution.
The Transformation of Communicative Power Into Political Power
Authors: Reunanen Esa , Kunelius Risto 
Published: August 2019

AbstractThis article examines Jürgen Habermas’ concept of communicative power and describes how it transforms into political power in actual decision-making. For this purpose, the article develops the use of Habermas’ typology of validity claims in communicative action as a framework for analysis. This means analyzing how public performances invoking these validity claims affect actors’ authority, which is then capitalized in policymaking. The article thus integrates Habermas’ procedural view on deliberative politics with the more culturally oriented view on political performances. It also contributes to the discussion about the “mediatization of politics” by introducing a communicative perspective to complement the more common institutional and systems perspectives. This theoretical and analytical approach is illustrated by examples drawn from evidence in 16 semi-structured interviews conducted with participants in the policy networks involved in the 2015 Finnish labor market negotiations.
Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy
Authors: Huang Yiyuan , Lu Haisong , Ren Xianfeng , Li Fazhao , Bu Weiming , Liu Wenjie , Dailey William P , Saeki Harumi , Gabrielson Kathleen , Abraham Roselle , Eckenhoff Roderic , Gao Wei Dong 
Published: August 2019

Abstract

Aims
Increased myofilament contractility is recognized as a crucial factor in the pathogenesis of hypertrophic cardiomyopathy (HCM). Direct myofilament desensitization might be beneficial in preventing HCM disease progression. Here, we tested whether the small molecule fropofol prevents HCM phenotype expression and disease progression by directly depressing myofilament force development.

Methods and results
Force, intracellular Ca2+, and steady-state activation were determined in isolated trabecular muscles from wild-type (WT) and transgenic HCM mice with heterozygous human α-myosin heavy chain R403Q mutation (αMHC 403/+). αMHC 403/+ HCM mice were treated continuously with fropofol by intraperitoneal infusion for 12 weeks. Heart tissue was analysed with histology and real-time PCR of prohypertrophic and profibrotic genes. Fropofol decreased force in a concentration-dependent manner without significantly altering [Ca2+]i in isolated muscles from both WT and αMHC 403/+ HCM mouse hearts. Fropofol also depressed maximal Ca2+-activated force and increased the [Ca2+]i required for 50% activation during steady-state activation. In whole-animal studies, chronic intra-abdominal administration of fropofol prevented hypertrophy development and diastolic dysfunction. Chronic fropofol treatment also led to attenuation of prohypertrophic and profibrotic gene expression, reductions in cell size, and decreases in tissue fibrosis.

Conclusions
Direct inhibition of myofilament contraction by fropofol prevents HCM disease phenotypic expression and progression, suggesting that increased myofilament contractile force is the primary trigger for hypertrophy development and HCM disease progression.
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: dental anomalies in 8-year olds
Authors: Rizell Sara , Bellardie Haydn , Karsten Agneta , Sæle Paul , Mooney Jeanette , Heliövaara Arja , Küseler Annelise , Brinck Eli , Skaare Pål , Mølsted Kirsten , Chalien Midia Najar , Marcusson Agneta , Eyres Phil , Shaw W , Semb Gunvor 
Published: August 2019

Summary

Background
Children born with unilateral cleft lip and palate (UCLP) are reported to display several dental anomalies including agenesis, supernumeraries, as well as variations in dental size, shape, and path of eruption. The extensive sample of individuals with UCLP included in the Scandcleft randomized control trials offers the opportunity to study more rare conditions, which is seldom possible with limited samples.

Objectives
The aim was to study dental anomalies at 8 years of age in children born with UCLP included in the Scandcleft randomized control trials.

Methods
Panoramic and intraoral radiographs from 425 individuals (279 males and 146 females) with a mean age of 8.1 years were assessed by four orthodontists regarding dental anomalies.

Results
Agenesis was found in 52.5 per cent and supernumerary teeth in 16.9 per cent of the participants. The cleft lateral was missing in 43.8 per cent and was found peg shaped in 44.7 per cent. The distribution of ectopic eruption was 14.6 per cent, mainly affecting maxillary first molars, while transposition was found in 3.4 per cent of the individuals. In addition, infraocclusion of one or several primary molars was registered in 7.2 per cent of the participants.

Conclusion
We conclude that 8-year-old children born with UCLP display multiple dental anomalies. The Scandcleft sample allowed rarely studied conditions such as infraocclusion of primary molars and transposition to be studied in children born with UCLP.

Trial registration
ISRCTN29932826.
Night sleep duration and sleep initiation time with hypertension in Chinese rural population: the Henan Rural Cohort
Authors: Zhang Haiqing , Zhao Xinyu , Li Yuqian , Mao Zhenxing , Huo Wenqian , Jiang Jingjing , Wang Yan , Liu Xiaotian , Abdulai Tanko , Tian Zhongyan , Tu Runqi , Qian Xinling , Liu Xue , Li Ruiying , Zhang Xia , Bie Ronghai , Wang Chongjian 
Published: August 2019

AbstractBackgroundThe study was conducted to evaluate the independent dose-response of the night sleep duration and sleep initiation time on hypertension, and to explore their combined effect with hypertension.MethodsParticipants from the Henan Rural Cohort were enrolled in this study. Information on sleep was collected using the Pittsburgh Sleep Quality Index. Hypertension was defined as systolic blood pressure/diastolic blood pressure ≥140/90 mmHg or self-reported hypertension and current use of anti-hypertensive medicines. Logistic regression and restricted cubic spline were conducted to evaluate the association of night sleep duration and sleep initiation time with hypertension.ResultsOf the 37 317 included participants, 12 333 suffered from hypertension. 14 474 (38.79%) were men and 22 843 (61.21%) were women, the mean age were 57.18 ± 12.10 and 55.24 ± 11.98 in men and women. Compared to reference (7–h), fully adjusted odd ratios (ORs) and 95% confidence interval (CI) of hypertension were 0.91 (0.66–1.25) in <5 h group and 1.74 (1.41–2.16) in ≥10 h among men, respectively. Fully adjusted ORs (95% CIs) for hypertension compared with reference (21:00–22:00) were 1.05 (95% CI 0.78–1.41) in the <20:00 group, 1.52 (1.25–1.85) in ≥24:00 in men. The combined effect of sleep duration and sleep initiation time on hypertension were statistically significant in the category of (≥8 h)/night and ≥24:00 (OR 1.87, 95% CI 1.07–3.25) compared to reference in fully adjusted model among men.ConclusionsLong night sleep duration and late sleep initiation time were associated with the higher odds of hypertension, and the sleep duration and sleep initiation time might cumulatively increase the prevalence of hypertension in men.Clinical trial registrationThe Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx? proj=11375.
Turkey and Cyprus: A Poliheuristic Analysis of Decisions during the Crises of 1964, 1967, and 1974
Authors: Özdamar Özgür , Ercİyas Okhan 
Published: August 2019

AbstractThe Cyprus problem is one of the most protracted and complex conflicts in the world. This article uses poliheuristic (PH) theory to analyze Turkey's decision-making during the Cyprus crises of 1964, 1967, and 1974. We utilize the PH model (Mintz 1993, 2004) and its method to systematically examine the decision-making process and outcomes during the three crises. We present primary evidence from governmental archives and secondary from media sources. The two hypotheses derived from the PH literature are supported by evidence. Results confirm Turkish decision-makers employed two-stage decision-making during each crisis. In the first stage, Turkish leaders followed the noncompensatory rule and eliminated options that could incur losses. In the second stage, their calculations were more in line with expected utility maximization. Implications of the case study in terms of PH model, foreign policy analysis, and international relations theory are discussed in the conclusion.
Volvulus of the ileal pouch–anal anastomosis: a meta-narrative systematic review of frequency, diagnosis, and treatment outcomes
Authors: Jawoosh Muhammad , Haffar Samir , Deepak Parakkal , Meyers Alyssa , Lightner Amy L , Larson David W , Raffals Laura H , Murad M Hassan , Buttar Navtej , Bazerbachi Fateh 
Published: August 2019

Abstract

Background
Proctocolectomy with ileal pouch–anal anastomosis (IPAA) is the surgical procedure of choice for medically refractory ulcerative colitis and familial adenomatous polyposis. While rare, a pouch volvulus can occur. We aimed to determine the frequency, presentation, and management approach of pouch volvulus in patients with IPAA.

Methods
A systematic search of published literature was performed by a medical reference librarian on 10 August 2018 and two independent reviewers identified relevant publications, extracted data, and assessed the methodological quality based on a validated tool. A retrospective review of the Mayo Clinic electronic medical records identified one case of pouch volvulus between January 2008 and August 2018.

Results
The frequency of pouch volvulus from one large published study reporting long-term outcomes of IPAA was 0.18% (3/1,700). A total of 22 patients (18 ulcerative colitis) were included (median age 32 years, 73% females). Median time to volvulus after IPAA was 36 months while median interval to volvulus diagnosis from symptom onset was 24 hours. Abdominal pain was the most commonly reported symptom (76%). The diagnosis was made primarily by abdominal computed tomography (13/17 patients, 76%). Endoscopic treatment was successful in 1 of 11 patients (9%). Surgery was performed in 20 patients and pouch-pexy and pouch excision were the most frequent surgical operations. A redo IPAA was performed in five patients (25%).

Conclusion
Pouch volvulus is a rare but serious complication of IPAA and should be suspected even in the absence of obstruction symptoms. Endoscopic treatment often fails and surgery is effective when performed early.
A new compositionally based thermal conductivity model for plutonic rocks
Authors: Jennings S , Hasterok D , Payne J 
Published: August 2019

SUMMARY
Thermal conductivity is a physical parameter crucial to accurately estimating temperature and modelling thermally related processes within the lithosphere. Direct measurements are often impractical due to the high cost of comprehensive sampling or inaccessibility and thereby require indirect estimates. In this study, we report 340 new thermal conductivity measurements on igneous rocks spanning a wide range of compositions using an optical thermal conductivity scanning device. These are supplemented by a further 122 measurements from the literature. Using major element geochemistry and modal mineralogy, we produce broadly applicable empirical relationships between composition and thermal conductivity. Predictive models for thermal conductivity are developed using (in order of decreasing accuracy) major oxide composition, CIPW normative mineralogy and estimated modal mineralogy.
Four common mixing relationships (arithmetic, geometric, square-root and harmonic) are tested and, while results are similar, the geometric model consistently produces the best fit. For our preferred model, $k_{\text{eff}} = \exp ( 1.72 \, C_{\text{SiO}_2} + 1.018 \, C_{\text{MgO}} - 3.652 \, C_{\text{Na}_2\text{O}} - 1.791 \, C_{\text{K}_2\text{O}})$, we find that SiO2 is the primary control on thermal conductivity with an RMS of 0.28 W m−1 K−1or ∼10 per cent. Estimates from normative mineralogy work to a similar degree but require a greater number of parameters, while forward and inverse modelling using estimated modal mineralogy produces less than satisfactory results owing to a number of complications. Using our model, we relate thermal conductivity to both P-wave velocity and density, revealing systematic trends across the compositional range. We determine that thermal conductivity can be calculated from P-wave velocity in the range 6–8 km s−1 to within 0.31 W m−1 K−1 using $k({V_p}) = 0.5822 \, V_p^2 - 8.263 \, V_p + 31.62$. This empirical model can be used to estimate thermal conductivity within the crust where direct sampling is impractical or simply not possible (e.g. at great depths). Our model represents an improved method for estimating lithospheric conductivity than present formulas which exist only for a limited range of compositions or are limited by infrequently measured parameters.
Predicting fluid pressure in sedimentary basins from seismic tomography
Authors: O’Reilly Brian M , Prada Manel , Lavoué François , Lebedev Sergei 
Published: August 2019

SUMMARY
Gravitational compaction of thick (2–10 km) sediment accumulations in sedimentary basins is controlled by the interplay of mechanical and chemical processes that operate over many orders of magnitude in spatial scale. The compaction of sediments into rock typically involves a density increase of ≈500 to 1000 kg m−3, occurring over a depth-scale of several kilometres. The volume decrease in the compacting sediments releases vast volumes of water, which plays an important part in the global hydrological cycle and also in tectonic and geochemical processes; including the formation of hydrocarbon and mineral deposits. This study utilizes recently developed tomographic seismic images from the Porcupine Basin, which lies in the deep-water North Atlantic Ocean. A generic method for predicting fluid pressure variations that are driven by gravitational compaction is developed over the scale of the entire sedimentary basin. The methodology is grounded upon both observational evidence and empirically based theories, relying on geophysical measurements and relationships between sediment porosities and densities. The method is based upon physical concepts that are widely used in the petroleum industry and applied extensively in models of overpressure development in sedimentary basins. Geological and geophysical data from exploration wells are used to test the predictions of the method at two locations within the basin and are found to be in good agreement with the theory.
Strengthening prevention in communities through systems change: lessons from the evaluation of Healthy Families NZ
Authors: Matheson Anna , Walton Mat , Gray Rebecca , Wehipeihana Nan , Wistow Jonathon 
Published: August 2019

Abstract
This article presents the findings from the first 3 years of the evaluation of Healthy Families NZ, a systems-change intervention to prevent chronic diseases in 10 communities. The initiative, which builds on existing prevention activities, aims to strengthen the health prevention system through evidence-driven action to enable people to make good food choices, be physically active, smoke-free and free from alcohol-related harm. Key investment areas are a dedicated systems thinking and acting health promotion workforce, and activating leaders who can influence transformational change. The evaluation to date has found the initiative is being implemented with integrity. Evidence indicates a shift towards greater action on prevention, and the prevention system being strengthened. Māori ownership has been enabled, and prioritizing equity has led teams to utilize methods that amplify diverse local perspectives. There is progress on developing a flexible workforce through adaptive learning, flexible resources, professional development and a responsive National team. There is also progress in activating local leadership and empowering local teams. The initiative design has explicitly taken into account the context of complexity within which it is being implemented. It has evolved to focus on action that can accelerate sharing information and practices within communities, and between policy and decision-makers. Healthy Families NZ and its evaluation have been refunded to 2022. This provides an important opportunity to gather further insight into effective ways to strengthen the community agency and trust needed to promote and deliver evidence-based action on prevention.
Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function
Authors: Cartwright James H , Aziz Qadeer , Harmer Stephen C , Thayyil Sudhin , Tinker Andrew , Munroe Patricia B 
Published: August 2019

Abstract
Stillbirth is the loss of a fetus after 22 weeks of gestation, of which almost half go completely unexplained despite post-mortem. We recently sequenced 35 arrhythmia-associated genes from 70 unexplained stillbirth cases. Our hypothesis was that deleterious mutations in channelopathy genes may have a functional effect in utero that may be pro-arrhythmic in the developing fetus. We observed four heterozygous, nonsynonymous variants in transient receptor potential melastatin 7 (TRPM7), a ubiquitously expressed ion channel known to regulate cardiac development and repolarization in mice.
We used site-directed mutagenesis and single-cell patch-clamp to analyze the functional effect of the four stillbirth mutants on TRPM7 ion channel function in heterologous cells. We also used cardiomyocytes derived from human pluripotent stem cells to model the contribution of TRPM7 to action potential morphology.
Our results show that two TRPM7 variants, p.G179V and p.T860M, lead to a marked reduction in ion channel conductance. This observation was underpinned by a lack of measurable TRPM7 protein expression, which in the case of p.T860M was due to rapid proteasomal degradation. We also report that human hiPSC-derived cardiomyocytes possess measurable TRPM7 currents; however, siRNA knockdown did not directly affect action potential morphology.
TRPM7 variants found in the unexplained stillbirth population adversely affect ion channel function and this may precipitate fatal arrhythmia in utero.