bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for circulating miR-208a and -b in different cardiac arrhythmias of dogs
Authors: Noszczyk-Nowak Agnieszka , Zacharski Maciej , Michałek Marcin 
Published: October 2018

Abstract

Introduction
In recent years, the high sensitivity and specificity of novel miRNA biomarkers have been utilised for early diagnosis and treatment monitoring of various diseases. Previous reports showed that abnormal expression of miR-208 in mice resulted in the development of an aberrant cardiac conduction system and consecutive arrhythmias. On the other hand, a study on infarcted human heart tissue showed upregulation of miR-208a in subjects with ventricular tachyarrhythmias compared to healthy controls. We prospectively investigated the expression of miR-208a and -208b in the serum of dogs presenting different cardiac arrhythmias.

Material and Methods
A total of 28 dogs with atrial fibrillation (n = 8), ventricular premature contractions (n=6), conduction system disturbances (n = 7), and free of heart conditions (as controls) (n = 7) were enrolled in the study. Total RNA was extracted from serum samples and miR-208a and -b, miR-16 as well as a cel-miR-39-5p spike-in were analysed with qPCR and ddPCR.

Results
miR-208a and miR-208b were not expressed in any of the samples. The calculated ddPCR miR-16 relative expression (normalised with cel-miR-39 spike-in) showed a good correlation (r = 0.82; P < 0.001) with the qPCR results.

Conclusion
This outcome warrants further investigation, possibly focusing on tissue expression of miR-208 in the canine heart.
Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats
Authors: Onoja Samuel Okwudili , Udem Samuel Chukwuneke , Anaga Aruh Ottah 
Published: October 2018

Abstract

Introduction
The study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.

Material and Methods
The cold maceration method with 80% methanol was used in the preparation of H. annuus extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A–E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, per os once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.

Results
The extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.

Conclusion

H. annuus extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.
Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing
Authors: Eftekhari Hadi , Jahandideh Alireza , Asghari Ahmad , Akbarzadeh Abolfazl , Hesaraki Saeed 
Published: October 2018

Abstract

Introduction
In recent years, the use of bone scaffolds as bone tissue substitutes, especially the use of such as hydroxyapatite and tricalcium phosphate, has been very popular. Today, the use of modern engineering techniques and advances in nanotechnology have expanded the use of nanomaterials as bone scaffolds for bone tissue applications.

Material and Methods
This study was performed on 60 adult male New Zealand rabbits divided into four experimental groups: the control group without any treatment, the second group receiving hydroxyapatite, the third group treated with β-tricalcium phosphate, and the fourth group receiving nanocomposite polycaprolactone (PCL) scaffold. In a surgical procedure, a defect 6 mm in diameter was made in a hind limb femur. Four indexes were used to assess histopathology, which were union index, spongiosa index, cortex index, and bone marrow.

Results
The results showed that nanocomposite PCL and control groups always had the respective highest and lowest values among all the groups at all time intervals. The histopathological assessment demonstrated that the quantity of newly formed lamellar bone in the nanocomposite PCL group was higher than in other groups.

Conclusion
All these data suggest that PCL had positive effects on the bone healing process, which could have great potential in tissue engineering and clinical applications.
The Impact of Radar Distance Measurement Accuracy on the Accuracy of Position Fixing in VTS Systems
Authors: Czaplewski Krzysztof , Guze Sambor , Świerczyński Sławomir 
Published: October 2018

Abstract
The main source of information on the situation across the sea basins used by operators of shipping monitoring systems is a network of coastal radar stations. Presently, it is possible to gather navigational information from many individual radar stations simultaneously, which may be used for improving the accuracy of vessel position fixing. However, without making other estimates, we obtain an inconsistent image comprising multiple echoes of the same ship, and as such it is impossible to say which echo presents the vessel on the move. Another problem is the method of performing radar observations, which significantly affects the accuracy of position fixing. The estimated radar distance is encumbered with a gross error in the case of large vessels, as the position of a large vessel is not the same as the position of the edge of the radar echo to which the estimation is made. In this paper, the authors present a method to adjust the measured radar distance. The proposed method may be automated easily, which would significantly enhance VTS positioning processes.
Ship Trajectory Tracking Control System Design Based on Sliding Mode Control Algorithm
Authors: Liu Yong , Bu Renxiang , Gao Xiaori 
Published: October 2018

Abstract
The paper reports the design and tests of the planar autopilot navigation system in the three-degree-of-freedom (3-DOF) plane (surge, sway and yaw) for a ship. The aim of the tests was to check the improved maneuverability of the ship in open waters using the improved nonlinear control algorithm, developed based on the sliding mode control theory for the ship-trajectory tracking problem of under-actuated ships with static constraints, actuator saturation, and parametric uncertainties. With the integration of the simple increment feedback control law, the dynamic control strategy was developed to fulfill the under-actuated tracking and stabilization objectives. In addition, the LOS (line of sight) guidance system was applied to control the motion path, whereas the sliding mode controller was used to emulate the rudder angle and propeller rotational speed control. Firstly, simulation tests were performed to verify the validity of the basic model and the tracking control algorithm. Subsequently, full scale maneuverability tests were done with a novel container ship, equipped with trajectory tracking control and sliding mode controller algorithm, to check the dynamic stability performance of the ship. The results of the theoretical and numerical simulation on a training ship verify the invariability and excellent robustness of the proposed controller, which: effectively eliminates system chattering, solves the problem of lateral drift of the ship, and maintains the following of the trajectory while simultaneously achieving global stability and robustness.
Economical and Safe Method of Granular Material Storage in Silos in Offshore Port Terminals
Authors: Sondej Mateusz , Ratnayake Chandana , Wójcik Michał 
Published: October 2018

Abstract
The article discusses issues related with storage of granular materials in silos made of corrugated sheets and reinforced with vertical ribs. Advantages and disadvantages of these structures are named, and typical technological solutions used by largest silo producers are presented. Moreover, basic assumptions of Eurocode 3 are discussed in the context of determining the buckling load capacity of a ribbed jacket. Alternative methods are indicated to determine the silo stability using analytical and FEM based methods. General conclusions are formulated with respect to designing of silos made of corrugated sheets.
Determination of Shear Modulus of Soil in the RC/TS Apparatus for Designing Offshore Wind Power Plant Foundations
Authors: Srokosz Piotr , Dyka Ireneusz , Bujko Marcin 
Published: October 2018

Abstract
The paper presents a selected aspect of the determining the initial soil shear modulus value on the research example in resonant column – torsional shear apparatus (RC / TS). There are presented the significance of the initial value of shear modulus in design of offshore wind power plant foundations and the importance of its variability in the function of cyclical shear strains of soil related to the impact of sea and atmosphere on the designed structures. Based on the conducted analyses, a new methodology for interpreting the TS test results of soil has been proposed. It allows estimating the values of the shear modulus in the full range of shear strains occurring in issues closely related to the design and construction work of offshore wind power plant foundations.
FEM Calculations in Analysis of Steel Subsea Water Injection Flowlines Designing Process
Authors: Wodtke Michał , Olszewski Artur , Wójcikowski Artur 
Published: October 2018

Abstract
The article describes the result of theoretical research aimed at assessing the loads and operating conditions of a Coiled Tubing pipeline injecting water, suspended to the mining platform of Lotos Petrobaltic. For this purpose, appropriate calculation models have been developed using the Finite Element Method (FEM), taking into account the nature of the analyzed object and its loads. The analyzes were carried out for two pipes (previously operated and newly proposed) differing in geometrical and strength parameters. The research was carried out for selected directions of load on the pipeline (originating from sea waves) and various variants of attaching the suspended pipeline to the mining platform.
Cold Cracking of S460N Steel Welded in Water Environment
Authors: Tomków Jacek , Łabanowski Jerzy , Fydrych Dariusz , Rogalski Grzegorz 
Published: October 2018

Abstract
This paper shows results of weldability testing of fine-grained high-strength low-alloy S460N steel welded in water environment by covered electrodes. The tests were carried out by using the CTS test specimens with fillet welds. Four specimens were welded under water and one specimen in air. Welded joints were subjected to non-destructive visual and penetration tests. The accepted joints were then subjected to macroscopic and microscopic inspection and Vickers hardness measurements as well. The experiments showed that S460N steel welded in water environment is characterized by a high susceptibility to cold cracking.
The Interpretation of the Authorial Creation of Vladimir Vysotsky on Contemporary Moscow Stages
Authors: Spodniaková Zuzana 
Published: October 2018

Abstract
The study presents an overview and analysis of contemporary Moscow productions inspired by the personality and work of the legendary Russian actor and poet of the latter half of the 20th century, singer and songwriter Vladimir Semyonovich Vysotsky (1938 – 1980). The authoress covers both the older productions which have been on the repertoires of theatres for several years and more recent productions staged this year on the occasion of the artist’s unlived 80th birthday. Researching on the productions by different theatre makers, staged by various theatres and drama ensembles, points at the importance and up-to-dateness of the creative legacy of Vladimir Vysotsky and at the significance of him as a personality that has become a legend and a component part of the cultural history of Soviet and post-Soviet eras. The productions constitute a significant part of the unwavering cult of his personality.
Sticker Emoticons Used in LINE Messenger; A Semantic Study
Authors: Nilasari Ni Luh , Sudipa I Nengah , Sukarini Ni Wayan 
Published: October 2018

This paper is entitled Sticker Emoticons Used in LINE Messenger; A Semantic Study. This study aims to identify and discuss visual, verbal signs and analyze the meaning and relationship between verbal and visual signs applied of sticker emoticon in the LINE messenger. The reason for choosing sticker emoticons is that they have great visualization that can present the human feelings in sending instant message as a media of communication. The data source was sticker emoticon from LINE group namely “SEVEN’ICHI”. In collecting the data, the method used is documentation. The data were taken from the screenshots of the messages using sticker emoticon. The collected data were qualitative analyzed based on the theories applied in this study, namely the theory of semiotics proposed by Saussure, and theory of sign proposed by Peirce. The data were presented in the form of table and description. The result of the analysis shows that there are two types of sticker emoticons found in Line messenger, big and small sizes. The difference of those could be seen from the size in which the big ones are created in the full body size while the small ones are only in the form of the heads.The signs consist of signifier and signified on verbal and visual sign. There were 21 verbal and visual signs found in this study, as well as Representamen, Object and Interpretant. In this study the sticker emoticons in LINE Messenger mean carry, happiness, sadness, satire, mental activities and physical activity. A sign cannot have a totally meaningless signifier or a completely formless signified and it cannot stand alone (Saussure 1983, 101; Saussure 1974, 102-103).
The Translation of English Figures of Speech Found in the Novel Temperatures Rising into Indonesian
Authors: Pebri Pranata I Putu , Isnu Maharani Sang Ayu , Netra I Made 
Published: October 2018

This study is entitled The Translation of English Figures of Speech Found in the novel Temperatures Rising into Indonesian. It was formulated two problems; types of figures of speech found in the novel entitled Temperatures Rising and the translation strategies implemented by translator to translate English figures of speech. It is aimed to find the types of figures speech in the novel and analyze the translation strategies implemented by the translator in the translation of the English figures of speech. The data which were used for this study were taken from an English romantic novel entitled Temperatures Rising in 1989 and its translation Hasrat Membara published by PT Gramedia Pustaka Utama in 2104. Documentation method was used in this study by reading attentivelt and doing note-taking. Qualitative method was used to analyze the data. Besides, the result of analysis is explained descriptively. Two theories proposed by Larson were applied in this study. The first theory that mentions the type of figures of speech was used to discuss the first problem. The second theory that explains the translation strategy was used to discuss the second problem. The study showed that there were six types of English figures of speech found in the novel. Based on the second formulated problem in this study, it showed that there were only two strategies implememted by the translator to translate the English figures of speech.
Calidad de la educación, formación y evaluación de docentes
Authors: Bernal de Rojas Aura Elena 
Published: October 2018

Los retos de la educación y la calidad.
La educación es la mejor herramienta para construir la sociedad. Ella es la vía social que articula a las colectividades con la cultura, el medio por la cual se recrea esta y avanzan las civilizaciones. Por ello, la educación ha sido tema de interés en todos los tiempos y resulta ser un elemento indispensable cuando se trata de perfilar el futuro.
Hoy a nivel mundial la educación tiene un carácter estratégico en la antesala del nuevo milenio caracterizado por la revolución del conocimiento, las comunicaciones y los espacios que ha desplegado la dinámica social, hechos que están afectando hondamente a nuestra nación.
La pedagogía como saber fundante de la formación del maestro. Algunas precisiones
Authors: Garcés Gómez Juan Felipe 
Published: October 2018

Preguntarse por el papel de la pedagogía como saber fundante de la formación del maestro, presupone ya la aceptación de algunos asuntos sumamente discutibles. En primer lugar, se presupone que sabemos qué es aquello que llamamos ‘pedagogía’ o que, al menos, hay algunos consensos sobre ella. Una rápida mirada a las recientes publicaciones en el país prueba que estamos muy lejos de lo que presuponemos, mientras algunos se aferran a la historia, otros se lanzan a conquistar los terrenos de la neurociencia o de la experiencia humana más íntima.
Postmodernismo: ¿Una posibilidad de desarrollar propuestas creativas en artes visuales?
Authors: Ruíz Solórzano Jaime 
Published: October 2018

Si bien hasta la década de los 60’s se tenía más o menos claro a que escuela o tendencia artística pertenecían los distintos objetos bi o tridimensionales creados, hoy tales referentes son difusos, las lecturas son disímiles y la crítica, mediadora entre el creador, la obra y el público, se encuentra cargada de metáforas y giros del lenguaje incomprensibles para el grueso de la población; es decir, el arte cada vez se hace más críptico, aún para los mismos comprometidos en el circuito de creación - valoración - difusión - consumo que asiste al arte.
En consecuencia, en nuestro medio, el estereotipo al cual se recurre con mucha frecuencia para dilucidar las creaciones visuales de las dos últimas décadas se fundamenta en el marco del postmodernismo, acatado sin la más mínima reflexión o posición crítica como si todo el mundo tuviese la certeza de lo que se explícita, acto propio de nuestra cultura simuladora.
Implicaciones de la ley general de cultura en el desarrollo educativo y cultural del la región
Authors: Sanchez Fierro Guillermo 
Published: October 2018

Quiero en la presente intervención abordar de manera breve cuatro aspectos: En primer lugar, una ilustración sobre nuestras raíces e identidad cultural. En segundo lugar, una reflexión sobre implicación de la identidad y el compromiso personal e institucional en el desarrollo educativo y cultural. En tercer lugar, algunos aspectos generales sobre la ley de cultura y en cuarto lugar, plantear unos requerimientos y compromisos institucionales mínimos para lograr la operatividad de la ley.
Propuesta de justificación del programa de licenciatura en matemáticas
Authors: Gutiérrez Hoyos Hernando 
Published: October 2018

La obligatoria necesidad, como condición de supervivencia, que tiene nuestro país de asumir los diferentes procesos de globalización característicos del mundo actual exige una “toma colectiva de conciencia” que comprometa tanto a gobernantes, dirigentes políticos y líderes empresariales como a todos los ciudadanos del común.
No se trata, únicamente, de preparamos para “aprender” a “manipular” u “operar” la múltiple, y cada vez más compleja, variedad de implementos producidos por la tecnología moderna que nos llegan a través de las multinacionales en busca de nuestros mercados, materias primas y mano de obra barata.
Los hijos de los conversos
Authors: Serrano Enrique 
Published: October 2018

Leyendo “De los judíos en la historia de Colombia’ de Daniel Mesa Bernal, pueden sacarse muchas, y muy impresionantes, conclusiones sobre el origen de nuestra idiosincrasia, y sobre la voluntad de acallado todo, que parece haber por debajo de la mentalidad que llevamos a cuestas. Por ejemplo, que la vida colombiana, y latinoamericana en general, carece de una historia que cuente quiénes fuimos, por qué vinimos y vivimos aquí, y qué nos ha movido a creer ya no en nuestras pobres naciones, en el sentido político y restringido, sino en lo que somos, es decir en estos muchos seres que amamos y odiamos.
Modelo matemático en el currículo del área agrícola en colegios agropecuarios
Authors: López Toledo Serafin , Rodríguez Gladys Aurora , Montealegre Mauro 
Published: October 2018

Este trabajo contiene un modelo matemático aplicable a la producción agrícola que relaciona los conceptos de las áreas agrícolas y matemáticas, de tal manera que se complementan y se sirven de apoyo para el desarrollo de la planeación del cultivo, proceso de investigación en producción y mercadeo de los productos. Se fundamenta en la concepción sistèmica de la educación y en la necesidad de evolución del campo teniendo como foco de proyección la Institución educativa de carácter técnico de la región.
La Matemática en los Colegios Agropecuarios sirve como herramienta para el desarrollo técnico y científico del campo, a la vez aporta modelos para ser analizados en el aula de clase y extrapolados como resultados para su aplicación en el proceso productivo.
El modelo expuesto es una construcción que coordina los conceptos de: Aritmética, Contabilidad, Estadística, Trigonometría, Análisis Matemático y los procesos de planeación, producción, mercadeo e investigación de plagas.
La pedagogía que yo quiero
Authors: Avendaño R. Álvaro E. 
Published: October 2018

Repasando los recientes acontecimientos universitarios, recuerdo, no sin nostalgia, estos versos que nos acompañan en los 70. Y es que el Estado, con la ilusión de los padres de antaño, nos trae las medidas de una novia perfecta, pero sus índices detallados y costosos informes sólo desnudan los "huesos y defectos" que afean a sus ojos nuestra universidad. Pues no; ella no necesita bañarse en esa agua bendita.
El Estado, en su paternal vanidadNcree que todo debe ser a su imagen y semejanza. Ya es hora de que sus hijos, como dicen las señoras: "inmaduros y todo", escojamos nuestro destino.
Lo sé porque lo he sufrido,'y es a este punto al que quiero referirme. Universidad Surcolombiana. Diciembre de 1,999. Gran presentación de iniciativas de postgrado. Ansioso, un grupo de desprevenidos profesores esperaba al evaluador del Consejo Nacional de Acreditación (CNA). Con anterioridad había presentado una propuesta de especialización en el área de la informática para los maestros de la región.
Universidad y Paz
Authors: Gutiérrez Hoyos Hernando 
Published: October 2018

Antes de iniciar con la temática escogida para disertar en este foro, deseo resaltar la presencia en el auditorio de los jóvenes estudiantes tanto de la universidad como de la escuela secundaria. A ellos, especialmente, va dirigido el mensaje que he preparado para esta audiencia ya que si vamos a hablar de construir y edificar procesos de Paz es con la juventud, básica y fundamentalmente, con quien debemos dialogar.
Lo anterior no quiere decir que los adultos deban retirarse del auditorio. Todo lo contrario; deben quedarse para que interactuemos dialógicamente con la juventud alrededor de este tema tan complejo, y últimamente tan manipulado, que es la Paz.
"La de-construcción curricular" de Nelson López Jiménez
Authors: Amaya de Ochoa Graciela 
Published: October 2018

No es por casualidad que en nuestro país, en los diferentes escenarios y eventos donde se hable sobre currículo, donde se piense su transformación, o donde se discutan alternativas pedagógicas y de formación, aparezcan los nombres de Nelson López y de Mario Díaz. Podríamos decir que se ha vuelto común, o más bien necesaria, la presencia de estos profesores, bien sea física o a través de sus escritos.
Tampoco es casual que cuando preguntamos acerca de qué alternativas proponer para superar el carácter fragmentado, jerárquico, insular, teorizante, memorístico, y descontextualizado de la mayoría de nuestros currículos, aparezca el Programa de Acción Curricular Alternativa -PACA-, que en el lenguaje cotidiano de educadores e investigadores, se le nombra como el modelo de los núcleos temáticos y problemáticos.