bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portfolio choice with small temporary and transient price impact
Authors: Ekren Ibrahim , Muhle‐Karbe Johannes 
Published: March 2019

AbstractWe study portfolio selection in a model with both temporary and transient price impact introduced by Garleanu and Pedersen. In the large‐liquidity limit where both frictions are small, we derive explicit formulas for the asymptotically optimal trading rate and the corresponding minimal leading‐order performance loss. We find that the losses are governed by the volatility of the frictionless target strategy, like in models with only temporary price impact. In contrast, the corresponding optimal portfolio not only tracks the frictionless optimizer, but also exploits the displacement of the market price from its unaffected level.
Neuromyths and Their Origin Among Teachers in Quebec
Authors: Blanchette Sarrasin Jérémie , Riopel Martin , Masson Steve 
Published: March 2019

ABSTRACTPrevious studies have revealed that “neuromyths,” which are misconceptions about the brain, show a high prevalence among teachers in different countries. However, little is known about the origin of these ideas; that is to say, the sources that may influence their presence among teachers. This research aims to identify the prevalence of five frequent neuromyths among teachers in Quebec (belief in neuromyths and reported practices) and the reported sources of these beliefs (e.g., reading popular science texts). A total of 972 teachers from Quebec responded to an online questionnaire. Results show a lower prevalence than previous studies (although it remains high), and that the main sources cited by participants are related to cognitive biases and university training. To our knowledge, this study is the first to report data supporting the idea that cognitive biases are related to the prevalence of neuromyths.
Normatively Speaking: Do Cultural Norms Influence Negotiation, Conflict Management, and Communication?
Authors: Ramirez Marin Jimena , Olekalns Mara , Adair Wendi 
Published: March 2019

AbstractThis paper elaborates a research agenda on cultural norms in communication, negotiation, and conflict management. Our agenda is organized around five questions on negotiation and conflict management, for example: How do culture and norms relate to an individual's propensity to negotiate? Or How do tightness‐looseness norms explain negotiators’ reactions to norm conformity and norm violation? And three questions on communication, for example: What individual and cultural factors lead negotiators to use miscommunication as an opportunity rather than an obstacle? Or Are there cultural differences in whether and what forms of schmoozing are normative? The present paper is based on three pillars: (a) ideas provided by the think tank participants (full list on website), (b) state of the art research and (c) the authors’ perspectives. Our goal is to inspire young, as well as, established researchers to purse these research streams and increase our understanding about the influence of cultural norms.
Induced pluripotent stem cell‐derived melanocyte precursor cells undergoing differentiation into melanocytes
Authors: Hosaka Chieko , Kunisada Makoto , Koyanagi‐Aoi Michiyo , Masaki Taro , Takemori Chihiro , Taniguchi‐Ikeda Mariko , Aoi Takashi , Nishigori Chikako 
Published: March 2019

AbstractInduced pluripotent stem cell (iPSC) technology offers a novel approach for conversion of human primary fibroblasts into melanocytes. During attempts to explore various protocols for differentiation of iPSCs into melanocytes, we found a distinct and self‐renewing cell lineage that could differentiate into melanocytes, named as melanocyte precursor cells (MPCs). The MPCs exhibited a morphology distinctive from that of melanocytes, in lacking either the melanosomal structure or the melanocyte‐specific marker genes MITF, TYR, and SOX10. In addition, gene expression studies in the MPCs showed high‐level expression of WNT5A, ROR2, which are non‐canonical WNT pathway markers, and its related receptor TGFβR2. In contrast, MPC differentiation into melanocytes was achieved by activating the canonical WNT pathway using the GSK3β inhibitor. Our data demonstrated the distinct characteristic of MPCs' ability to differentiate into melanocytes, and the underlying mechanism of interfacing between canonical WNT signaling pathway and non‐canonical WNT signaling pathway.
Pediatric post‐transplant hepatic kaposi sarcoma due to donor‐derived human herpesvirus 8
Authors: Ocwieja Karen E. , Vargas Sara O. , Elisofon Scott A. , Shulman David S. , Lee Christine K. , Fawaz Rima , Collins Natalie , Vakili Khashayar , Sharma Tanvi S. 
Published: March 2019

AbstractIn areas of the world where human herpesvirus 8 (HHV‐8) is endemic, Kaposi sarcoma (KS) is a common SOT‐associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. The donor was a male with no known history of KS, originally from an HHV‐8‐endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor‐derived. HHV‐8 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV‐8 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV‐8‐endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.
Geological controls on the geometry of incised‐valley fills: Insights from a global dataset of late‐Quaternary examples
Authors: Wang Ru , Colombera Luca , Mountney Nigel P. 
Published: March 2019

AbstractIncised valleys that develop due to relative sea‐level change are common features of continental shelves and coastal plains. Assessment of the factors that control the geometry of incised‐valley fills has hitherto largely relied on conceptual, experimental or numerical models, else has been grounded on case studies of individual depositional systems. Here, a database‐driven statistical analysis of 151 late‐Quaternary incised‐valley fills has been performed, the aim being to investigate the geological controls on their geometry. Results of this analysis have been interpreted with consideration of the role of different processes in determining the geometry of incised‐valley fills through their effect on the degree and rate of river incision, and on river size and mobility. The studied incised‐valley fills developed along active margins are thicker and wider, on average, than those along passive margins, suggesting that tectonic setting exerts a control on the geometry of incised‐valley fills, probably through effects on relative sea‐level change and river behaviour, and in relation to distinct characteristics of basin physiography, water discharge and modes of sediment delivery. Valley‐fill geometry is positively correlated with the associated drainage‐basin size, confirming the dominant role of water discharge. Climate is also inferred to exert a potential control on valley‐fill dimensions, possibly through modulations of temperature, peak precipitation, vegetation and permafrost, which would in turn affect water discharge, rates of sediment supply and valley‐margin stability. Shelves with slope breaks that are currently deeper than 120 m contain incised‐valley fills that are thicker and wider, on average, than those hosted on shelves with breaks shallower than 120 m. No correlation exists between valley‐fill thickness and present‐day coastal‐prism convexity, which is measured as the difference in gradient between lower coastal plains and inner shelves. These findings challenge some concepts embedded in sequence stratigraphic thinking, and have significant implications for analysis and improved understanding of ‘source to sink’ sediment route‐ways, and for attempting predictions of the occurrence and characteristics of hydrocarbon reservoirs.
Sharenting: Pride, affect and the day‐to‐day politics of digital mothering
Authors: Lazard Lisa , Capdevila Rose , Dann Charlotte , Locke Abigail , Roper Sandra 
Published: March 2019

AbstractThe coming together of parenting and routine posting on social networking sites has become a visible and recognisable theme, and the term “sharenting” has found a place in everyday talk to describe some forms of parental digital sharing practices. However, while social media has undoubtedly provided a space for parents to share experiences and receive support around parenting, sharenting remains a contestable issue. Thus, one reading of sharenting would be as a display of good parenting as mothers “show off” their children as a marker of success. However, the term also can be used pejoratively to describe parental oversharing of child‐focused images and content. In this paper, we explore the practice of sharenting in terms of pride, affect and the politics of digital mothering in a neoliberal context to conclude that sharenting can be best understood as a complex affective and intersectional accomplishment that produces motherhood and family as communicative activities within digital social practices.
Perceptions and attitudes of swine exhibitors towards recommendations for reducing zoonotic transmission of influenza A viruses
Authors: Nolting Jacqueline M. , Scheer Scott D. , Bowman Andrew S. 
Published: March 2019

AbstractSince 2011, there have been 468 cases of variant influenza A virus (IAV) reported in the United States, many of which were associated with youth swine exhibition. In an effort to mitigate risk associated with exposure to IAV in swine, the “Measures to Minimize Influenza Transmission at Swine Exhibitions” (MtM) was developed for show organizers, volunteers and exhibitors. These recommendations are updated annually; however, it is not clear if youth swine exhibitors are aware of the recommendations; support the recommendations; and would be willing to practise recommended behaviours. Therefore, a cross‐sectional survey method was used to assess swine exhibitor perceptions and their adoption of swine production practices aimed at reducing the transmission of IAV at the human–animal interface. In addition, the survey asked participants their state of residence and the number of shows they would attend in 2017. In all, 155 participants who showed swine on a regular basis (x̅ = 11 shows per year), from at least 18 states within the US, completed the survey. At least, 67% of participants believed each statement was a good recommendation, with 6 of 11 recommendations being supported by >90% of participants. When asked if recommendations could be implemented, 65%–94% of respondents agreed, and 21%–89% of participants had already implemented each recommendation, respectively. Although significant efforts have been made to increase signage at swine exhibitions (warning of risks associated with eating/drinking in animal areas), a majority of respondents report eating/drinking in the barn and are unwilling to change their behaviours. This study provides evidence that developing and disseminating static recommendations to reduce zoonotic disease transmission is not enough to change human behaviour to prevent future variant IAV infections associated with swine exhibitions.
Morphologic and genetic variability in the Barbus fishes (Teleostei, Cyprinidae) of Central Italy
Authors: Zaccara Serena , Quadroni Silvia , Vanetti Isabella , Carosi Antonella , La Porta Gianandrea , Crosa Giuseppe , Britton Robert , Lorenzoni Massimo 
Published: March 2019

AbstractItalian freshwaters are highly biodiverse, with species present including the native fishes Barbus plebejus and Barbus tyberinus that are threatened by habitat alteration, fish stocking and invasive fishes, especially European barbel Barbus barbus. In central Italy, native fluvio‐lacustrine barbels are mainly allopatric and so provide an excellent natural system to evaluate the permeability of the Apennine Mountains. Here, the morphologic and genetic distinctiveness was determined for 611 Barbus fishes collected along the Padany–Venetian (Adriatic basins; PV) and Tuscany–Latium (Tyrrhenian basins; TL) districts. Analyses of morphological traits and mitochondrial DNA sequence data explored the natural and anthropogenic factors that have shaped their distribution ranges. Over 100 alien B. barbus were recorded in the Tiber basin (TL district) and Metauro basin (PV district). Comparisons of genetic and morphometric data revealed that morphometric data could identify alien B. barbus from native Barbus, but could not differentiate between B. tyberinus and B. plebejus. Genetic analyses revealed ~50 D‐loop mtDNA haplotypes and identified a distinct Barbus lineage present only in the Vomano River at the southern boundary of PV district. Demographic expansion and molecular variance analyses revealed a lack of geographic structuring across the sampling regions. While the contemporary B. plebejus distribution has been driven primarily by anthropogenic fish translocations, the dispersal of B. tyberinus has been via natural dispersion, including their crossing of the Apennine Mountains via temporary river connectivity. The results also revealed that the Barbus fishes of the mid‐Adriatic region of Europe have a complex pattern of local endemism. To conserve these patterns of genetic uniqueness, especially in the mid‐Adriatic basins, Barbus fishes should be managed by treating them as unique evolutionary units and ceasing translocations of all Barbus fishes between river basins.
Interval running training improves age‐related skeletal muscle wasting and bone loss: Experiments with ovariectomized rats
Authors: Kim Jeong‐Seok , Jeon Jin , An Jin‐Jeong , Yi Ho‐Keun 
Published: March 2019

New Findings
What is the central question of this study?
What is the effect and mechanism of interval running training on age‐related muscle wasting and bone loss in an ovariectomized rat model?

What is the main finding and its importance?
Interval running training improved muscle growth and osteogenic differentiation by enhancing the expression of bone morphogenic proteins and sirtuins in ageing‐induced ovariectomized rats. Therefore, the repetition of low and high intensities within a single exercise bout, such as interval running training, may be recommended as a practical intervention to prevent skeletal muscle wasting and bone loss in the elderly.

AbstractEffective prophylactic strategies are needed for the suppression of age‐related muscle wasting and bone loss after menopause. Exercise training is attractive due to its potential for improving energy metabolism, as well as age‐related muscle wasting and bone loss. In particular, interval running (IR) training involves a repetition of low and high intensities within a single exercise bout. Therefore, this study elucidated the effect of interval training on muscle and bone health, as well as anti‐ageing, in ovariectomized (OVX) rats. The anti‐ageing effect of IR on muscle and bone was tested using western blotting and micro‐computed tomography analysis, tartrate‐resistant acid phosphatase and immunohistochemical staining. IR significantly inhibited the expression of inflammatory molecules, and improved antioxidant activity via down‐regulation of mitogen‐activated protein kinases (MAPKs) in the ageing‐induced OVX rats skeletal muscle. IR compared with continuous running (CR) improved muscle mass and growth in OVX rats by the promotion of muscle growth‐related factors including MyoD, myogenin, phospho‐mechanistic target of rapamycin (p‐mTOR), sirtuins (SIRTs), and bone morphogenic proteins (BMPs). IR also effectively recovered OVX‐induced bone loss via the down‐regulation of bone resorption and osteoclast formation in receptor activator of nuclear factor κB ligand (RANKL)‐treated bone marrowmacrophages (BMMs). In particular, IR led to high expression of SIRT1 and 6, which promoted osteogenic differentiation and bone formation via modulating the BMP signalling pathway compared with CR training. The in vivo effect of IR was confirmed by immunohistochemical staining with the improvement of bone formation molecules such as BMPs and SIRTs. These results suggested that IR training affected myogenic and osteogenic formation. So, IR training may be considered for prevention of muscle wasting and bone loss for the elderly.
Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study
Authors: Savolainen-Peltonen Hanna , Rahkola-Soisalo Päivi , Hoti Fabian , Vattulainen Pia , Gissler Mika , Ylikorkala Olavi , Mikkola Tomi S 
Published: March 2019

Abstract

Objectives
To compare the use of hormone therapy between Finnish postmenopausal women with and without a diagnosis for Alzheimer’s disease.

Design
Nationwide case-control study.

Setting
Finnish national population and drug register, between 1999 and 2013.

Participants
All postmenopausal women (n=84 739) in Finland who, between 1999 and 2013, received a diagnosis of Alzheimer’s disease from a neurologist or geriatrician, and who were identified from a national drug register. Control women without a diagnosis (n=84 739), matched by age and hospital district, were traced from the Finnish national population register.

Interventions
Data on hormone therapy use were obtained from the Finnish national drug reimbursement register.

Main outcome measures
Odds ratios and 95% confidence intervals for Alzheimer’s disease, calculated with conditional logistic regression analysis.

Results
In 83 688 (98.8%) women, a diagnosis for Alzheimer’s disease was made at the age of 60 years or older, and 47 239 (55.7%) women had been over 80 years of age at diagnosis. Use of systemic hormone therapy was associated with a 9-17% increased risk of Alzheimer’s disease. The risk of the disease did not differ significantly between users of estradiol only (odds ratio 1.09, 95% confidence interval 1.05 to 1.14) and those of oestrogen-progestogen (1.17, 1.13 to 1.21). The risk increases in users of oestrogen-progestogen therapy were not related to different progestogens (norethisterone acetate, medroxyprogesterone acetate, or other progestogens); but in women younger than 60 at hormone therapy initiation, these risk increases were associated with hormone therapy exposure over 10 years. Furthermore, the age at initiation of systemic hormone therapy was not a decisive determinant for the increase in risk of Alzheimer’s disease. The exclusive use of vaginal estradiol did not affect the risk of the disease (0.99, 0.96 to 1.01).

Conclusions
Long term use of systemic hormone therapy might be accompanied with an overall increased risk of Alzheimer’s disease, which is not related to the type of progestogen or the age at initiation of systemic hormone therapy. By contrast, use of vaginal estradiol shows no such risk. Even though the absolute risk increase for Alzheimer’s disease is small, our data should be implemented into information for present and future users of hormone therapy.
Upper Ordovician bryozoans of Morocco
Authors: Ernst Andrej 
Published: March 2019

Abstract
The majority of Upper Ordovician bryozoan occurrences in Morocco are known from the Anti-Atlas. These faunas are abundant and diverse; however, many of them still remain unstudied. The few explored bryozoan faunas of the Katian age exhibit high abundance and diversity of erect branched and massive trepostomes accompanied by few esthonioporines, cryptostomes and fenestrates, whereas cystoporate bryozoans are not known here. They occupied various biotopes within inner- and outer-ramp settings. Bryozoan faunas from the Upper Ordovician of Morocco are rather related to faunas from other parts of the Mediterranean Province (France, Carnic Alps, Sardinia) containing few species of Laurentian and Baltic origin. Trepostome bryozoans from Moroccan occurrences often display signs of gigantism explained by undisturbed growth in cold and quiet environmental conditions.
Assessing the Nationwide Impact of a Registry-Based Randomized Clinical Trial on Cardiovascular Practice
Authors: Buccheri Sergio , Sarno Giovanna , Fröbert Ole , Gudnason Thorarinn , Lagerqvist Bo , Lindholm Daniel , Maeng Michael , Olivecrona Göran , James Stefan 
Published: March 2019

Background:
Registry-based randomized clinical trials have emerged as useful tools to provide evidence on the comparative efficacy and safety of different therapeutic strategies. However, it remains unknown whether the results of registry-based randomized clinical trials have a sizable impact on daily clinical practice. We sought, therefore, to describe the temporal trends in thrombus aspiration (TA) use in Sweden before, during, and after dissemination of the TASTE trial (Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia) results.

Methods and Results:

From January 1, 2006, to December 31, 2017, we included all consecutive patients with ST-segment–elevation myocardial infarction undergoing percutaneous revascularization in Sweden. All patients were registered in the Swedish Coronary Angiography and Angioplasty Registry. A total of 55 809 ST-segment–elevation myocardial infarction patients were included. TA use in Sweden substantially decreased after dissemination of TASTE results (from 39.8% to 11.8% during and after TASTE, respectively). Substantial variability in TA use across treating centers was observed before TASTE (TA use ranging from 0% to 70%), but after TASTE both the interhospital variability and the frequency of TA use were markedly reduced. A constant shift in medical practice was seen about 4 months after dissemination of the TASTE trial results. Time trends for all-cause mortality and definite stent thrombosis at 30 days were not associated with variations in TA use (
P
values >0.05 using the Granger test).

Conclusions:
In Sweden, the results of the TASTE trial were impactful in daily clinical practice and led to a relevant decrease in TA use in ST-segment–elevation myocardial infarction patients undergoing percutaneous revascularization.