bluuebunny/crossref_metadata_2025_split huggingface dataset:
A musealização de um passado ambíguo: O caso dos lugares de isolamento compulsório, entre afetos privados e a transmissão de uma memória heroica da saúde
Authors: Bezerra Daniele Borges , Serres Juliane Conceição Primon 
Published: May 2019

A transmissão do passado está condicionada à criação de dispositivos memoriais que estruturam as memórias na forma de narrativas. Assim, quando as memórias são investidas de valor patrimonial, migram do universo individual para o espaço público. Entretanto, devido ao aspecto delicado de algumas memórias, defrontamo-nos com um dilema situado entre o compromisso ético de seu reconhecimento e as formas de transmissão do passado, que pode ser incômodo. Discutiremos o reconhecimento patrimonial de lugares marcados por memórias difíceis: as antigas colônias de isolamento sanitário, criadas para o isolamento da lepra. Para isso, tomaremos como estudo de caso o Hospital-Colônia Itapuã (RS). Analisaremos o modo como as memórias do lugar são acionadas pelo dispositivo de memória criado no hospital e qual a opinião dos antigos moradores sobre esses dispositivos.
Uma espécie asiática invade a paisagem do sul do Brasil
Authors: Carvalho Aline Beatriz Pacheco , Bem Judite Sansonde , Almerão Maurício Pereira , Cademartori Cristina Vargas 
Published: May 2019

Este ensaio visual versa sobre a temática da invasão biológica como consequência da ação antrópicae seus impactosnegativos ao patrimônio natural. Os registros fotográficos foram obtidos entre março e abril de 2018 no município de Itati, Rio Grande do Sul, organizados através de legendas explicativas e discutidos a partir de fontes orais e bibliográficas. As fotografias evidenciam a presença da espécie exótica invasora Hoveniadulcis (uva-do-japão) na unidade de conservação Reserva Biológica Estadual Mata Paludosa e em áreas limítrofes,revelando a situação de fragilidade dos últimos remanescentes de Mata Paludosa no Rio Grande do Sul.
Pathologic Changes in the Liver During Acute Exposure to Clozapine and Its Combination with Ethanol (Experimental Study)
Authors: Romanova O. L. , Sudukov D. V. , Golubev M. A. , Blagonravov M. L. , Goshkoev V. V. , Churilov A. A. 
Published: May 2019

Purpose: identification of pathological changes in the liver at early stages of the effect of clozapine and clozapine combined with ethanol to improve the diagnosis of this acute exposure.Materials and methods. The experiments were carried out on outbred male rats (n=15). The animals were split into 3 groups, 5 animals in each: 1) control (intact rats); 2) clozapine, 3) clozapine and ethanol. Clozapine at a dose of 150 mg/kg of the animal’s body weight was administered orally under anesthesia (chloralose), clozapine (150 mg/kg) with ethanol at a dose of 5 ml/kg — orally. Rats were removed from the experiment after 3 hours by decapitation. Samples of liver tissue were studied using light microscopy. During histological examination, the following morphological signs were evaluated: blood circulation disorder (presence of venous, capillary, and arterial congestion, appearance of venous hemorrhage), absence of nuclei staining, cytoplasm lumpiness, cytoplasm vacuolation, presence of necrosis foci, appearance of cellular response (a large quantity of leukocytes per power field). The assessment was done using the F-test. Forensic chemical analysis was carried out using a high-performance liquid chromatograph equipped with a mass detector. The content of clozapine, norclozapine, and clozapine-N-oxide in blood serum and liver homogenate of rats was evaluated.Results. In the control group, no pathological changes in liver tissue were observed. 3 hours after clozapine administration, venous congestion was detected. 3 hours after administration of clozapine and ethanol combination, venous congestion and absence hepatocyte nuclei staining were observed. It was found that after combined administration of clozapine and ethanol, the blood serum clozapine was 1.94-fold and clozapine-N-oxide was 2.3-fold lower than when clozapine was administered as a single drug while the content of norclozapine showed no difference.Conclusion. Changes detected in the liver, together with changes in other organs and findings of the forensic chemical analysis, allow establishing the fact of clozapine poisoning. Understanding of the processes going on in the body during such intoxications helps rendering medical assistance to victims more effectively.
Anesthetic Management of Patients with a Type A Aortic Dissection
Authors: Silvay G. , Khromava M. , Weiner M. , Augoustides J. G. , Castillo J. G. 
Published: May 2019

«It is type of surgery that is not for the lone operator… Team is of course essential in the operating theater, where in addition to the surgical and nursing assistants, the anesthesiologist plays a part of fundamental importance which deserves a special tribute.» Russel C. Brock, 1949 Deep hypothermic circulatory arrest (DHCA) for the adult aortic arch repair is still associated with significant mortality and morbidity. Furthermore, there is significant variation in the conduct of this complex perioperative technique. The variation in the practice of DHCA has not been adequately characterized and may offer multiple therapeutic opportunities for outcome enhancement and reduction of procedural risk. The International Aortic Arch Study Group (IAASSG) was recently organized to investigate an optimal neuroprotection during the thoracic aortic reconstruction.
University students´ perception of exposure to various English accents and their production
Authors: Charpentier-Jiménez William 
Published: May 2019

This article presents students’ perception of English accent varieties in a BA in English and a BA in English Teaching. The purpose of this study was to find out higher education students’ opinions on the incorporation of further English accents in their major. Until now, this topic has not been deeply studied in the Costa Rican context. Results were obtained from a 16-point survey answered by 77 participants. Based on these results, the writer explains that a need to include a variety of native and non-native English accents exists and that a language program would benefit from it. The results demonstrate that 76.6% of students consider being able to imitate several types of English accents important, while 93.5% believe that what is important is being able to recognize and understand several accents. Data show that the majority of students consider the incorporation of various types of accents in their major essential. In practical terms, these results should promote a curricular change where several types of English accents should be incorporated.
Las tecnologías computacionales y su repercusión en el proceso de formación matemática en la República de Angola
Authors: Faustino Arnaldo , Wongo Gungula Eurico , Arrocha Rodríguez Olaysi 
Published: May 2019

Las Tecnologías de la Información y las Comunicaciones (TIC), promueven el desarrollo económico, socio-cultural y educacional. Asimismo, cualquier adelanto científico vinculado con ellos, impone cambios significativos en los ámbitos sociales, tanto en las exigencias derivadas de las innovaciones en los entornos laborales como también para hacer frente a las transformaciones que se producen actualmente en la dinámica del proceso de enseñanza-aprendizaje de la Matemática. Sin embargo, las insuficiencias metodologicas en la formación matemática desde 2011 hasta 2016 en las Instutuciones Superiores Pedagógicas Angoleñas, limitan la apropiación de los conocimientos tecnológicos de los estudiantes del perfil pedagógico en el proceso de solución de problemas. Por consiguiente, el presente artículo tiene como objetivo; diagnosticar la situación actual del proceso de enseñanza-aprendizaje de la Matemática, en la utilización de las tecnologías computacionales en su desempeño investigativo, a fin de minimizar las inconsistencias en la contextualización de los problemas en su proceso formativo y promover eficazmente la utilización de las TIC en las investigaciones que demandan las necesidades sociales. Para la instrumentación de los resultados alcanzados en la pesquisa, se aplicó la metodología cuali-cuantitativa en su implementación y el software IBM SPSS Statistics 20, al procesamiento de la información.
Filling gaps in flower fly distributions: first record of Aneriophora aureorufa (Philippi, 1865) (Diptera, Syrphidae) from Argentina
Authors: López-García Guillermo , Barahona-Segovia Rodrigo Moisés , Maza Noelia , Domínguez Martha Cecilia , Mengual Ximo 
Published: May 2019

The genus Aneriophora Stuardo & Cortés 1952, previously considered endemic to Chile, is recorded for the first time from Argentina. Specimens of Aneriophora aureorufa (Philippi, 1865) were collected in Neuquén Province and deposited in the entomological collection of the Instituto Argentino de Zonas Áridas, Mendoza, Argentina. A diagnosis, distribution map, and photographs of A. aureorufa are provided.
A Phase I/II Open-Label Study of Nivolumab in Previously Treated Advanced or Recurrent Nasopharyngeal Carcinoma and Other Solid Tumors
Authors: Ma Yuxiang , Fang Wenfeng , Zhang Yang , Yang Yunpeng , Hong Shaodong , Zhao Yuanyuan , Tendolkar Amol , Chen Lu , Xu Dong , Sheng Jennifer , Zhao Hongyun , Zhang Li 
Published: May 2019

AbstractLessons LearnedNivolumab treatment at doses of 3 mg/kg once every 2 weeks (Q2W), 240 mg Q2W, and 360 mg once every 3 weeks was well tolerated in the Chinese population, with no new safety signals identified. Comparison of intensive pharmacokinetic profiles of nivolumab at 3 mg/kg Q2W in Chinese versus global populations revealed no ethnic differences of nivolumab treatment. Nivolumab shows promising preliminary antitumor activity in nasopharyngeal carcinoma.BackgroundThis phase I/II study investigated the safety and pharmacokinetics (PK) of nivolumab (anti-programmed cell death-1 monoclonal antibody) in Chinese patients with nasopharyngeal carcinoma (NPC) and other solid tumors.MethodsA dose evaluation phase (3 mg/kg once every 2 weeks [Q2W]) was followed by a cohort expansion phase (3 mg/kg Q2W or flat doses of 240 mg Q2W or 360 mg once every 3 weeks).ResultsIn the dose evaluation phase, 8/8 patients completed one cycle with no dose-limiting toxicities. At data cutoff, 46/51 patients were evaluable for safety (all cohorts). Treatment-related adverse events (TRAEs) occurred in 35 (76%) patients and were primarily grade 1–2; one patient (3 mg/kg Q2W) discontinued because of study drug toxicity. Intensive PK profiles at 3 mg/kg, 240 mg, and 360 mg were well characterized at single and multiple doses of nivolumab. An objective response was determined in six (6/46) patients, four (4/32) of whom had NPC tumors.ConclusionNivolumab monotherapy at 3 mg/kg and flat doses of 240 mg and 360 mg were well tolerated in this Chinese patient population, with PK profiles at 3 mg/kg being similar to those of global patients. Preliminary efficacy results showed promising antitumor activity of nivolumab in advanced NPC.
Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes
Authors: Sugahara Sho , Kume Shinji , Chin-Kanasaki Masami , Tomita Issei , Yasuda-Yamahara Mako , Yamahara Kosuke , Takeda Naoko , Osawa Norihisa , Yanagita Motoko , Araki Shin-ichi , Maegawa Hiroshi 
Published: May 2019

Significance Statement
Lipolysis is of particular importance for energy homeostasis in proximal tubular epithelial cells (PTECs), and it is dysregulated during the pathogenesis of diabetic kidney disease. In knockout mice lacking O-GlcNAc transferase specifically in PTECs, the authors demonstrated that protein O-GlcNAcylation, an intracellular nutrient sensing system, is essential for renal lipolysis and ATP production during prolonged fasting. They also found evidence that this novel regulatory mechanism of renal lipolysis involves farnesoid X receptor–dependent upregulation of carboxylesterase-1 and that deficiency of renal protein O-GlcNAcylation exacerbates tubulopathy in diabetic kidney disease. These findings suggest that manipulation of the renal lipolytic mechanism to overcome the effects of prolonged fasting might represent a novel therapeutic approach for diabetic kidney disease.

Background
Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis of diabetic tubulopathy. Emerging evidence suggests that protein O-GlcNAcylation, an intracellular nutrient-sensing system, may regulate a number of metabolic pathways according to changes in nutritional status. Although O-GlcNAcylation in PTECs has been demonstrated experimentally, its precise role in lipolysis in PTECs is unclear.

Methods
To investigate the mechanism of renal lipolysis in PTECs—specifically, the role played by protein O-GlcNAcylation—we generated mice with PTECs deficient in O-GlcNAc transferase (Ogt). We analyzed their renal phenotypes during ad libitum feeding, after prolonged fasting, and after mice were fed a high-fat diet for 16 weeks to induce obesity and diabetes.

Results
Although PTEC-specific Ogt-deficient mice lacked a marked renal phenotype during ad libitum feeding, after fasting 48 hours, they developed Fanconi syndrome–like abnormalities, PTEC apoptosis, and lower rates of renal lipolysis and ATP production. Proteomic analysis suggested that farnesoid X receptor–dependent upregulation of carboxylesterase-1 is involved in O-GlcNAcylation’s regulation of lipolysis in fasted PTECs. PTEC-specific Ogt-deficient mice with diabetes induced by a high-fat diet developed severe tubular cell damage and enhanced lipotoxicity.

Conclusions
Protein O-GlcNAcylation is essential for renal lipolysis during prolonged fasting and offers PTECs significant protection against lipotoxicity in diabetes.
Effect of heat treatment of quartzite on the mechanism of destruction of the lining of induction furnaces
Authors: Zavertkin A. S. 
Published: May 2019

The mechanism of wear of quartzite lining of induction crucible furnaces during the smelting of iron and steel is presented. It has been established that the main cause of lining wear is a decrease in its strength caused by the transition of the tridimite joint into cristobalite, which is much easier to wash off the walls of the crucible with moving metal and slag. The second important factor of wear is the choice of quartzite raw materials, its material and granulometric compositions, the firing mode and the technology of melting during operation of the furnace. Silicon recovery from silica of carbonization lining by carburizer and cast iron, which is part of, is a secondary factor of crucible lining wear. Ill. 4. Ref. 5. Tab. 1.
Tecnologia para uma prática pedagógica inclusiva: o uso do aplicativo Open Office Writer
Authors: Belo Angeluci Alan Cesar , Mota Ferreira Baena Priscila 
Published: May 2019

O Transtorno do Espectro Autista (TEA) é caracterizado pelo comprometimento nas áreas de interação social, comunicação e comportamentos restritos e repetitivos. A cada dia mais crianças são matriculadas com este transtorno neurobiológico nas escolas regulares, porém pesquisas apontam que crianças com TEA apresentam mais dificuldade em aprender por métodos tradicionais. Com base nessas pesquisas este artigo apresenta possibilidades do uso de um aplicativo aberto e gratuito Open Office Writer, propondo melhorias na comunicação e atenção dessas crianças, promovendo assim a inclusão digital.
Novas maneiras de ressignificar, de participar e de colaborar na era da mobilidade informacional
Authors: Moura Vagner Aparecido de 
Published: May 2019

RESUMO: As cidades desplugadas, na era da supermodernidade, impelem-nos a discutir, no presente artigo, o termo mobilidade informacional, com a finalidade de desnaturatizá-lo e trazer, à baila, as adversidades subjacentes a essa nova forma de subjetivação, de individuação e de mobilidade. Para lograr êxito nesse processo hermenêutico e investigativo, será utilizado como procedimento metodológico a revisão de literatura, embasada nos seguintes autores: Lemos (2007a, 2007b, 2008, 2009), Rivière (2006) e Tuan (2003). A intenção é de não só discutir as implicações entre mobilidade versus comunicação de massa, o processo de configuração e a reconfiguração do território informacional, mas também empoderar o coenunciador a tornar-se um “bricoleur” da transmodernidade, com o intuito de discutir o conceito de identidade na contemporaneidade e, assim, ressignificar o seu olhar no momento em que participa, colabora no processo de construção de novas maneiras de estabelecer vínculos e laços de pertencimento.
PALAVRAS-CHAVE: mobilidade informacional; cidades desplugadas; individuação; subjetivação.

ABSTRACT:
The unplugged cities, in the age of Supermodernity, lead us to discuss the term informational mobility in this article, aiming at denaturalizing it and bringing up underlying adversities to this new manner of subjectivation, individuation and mobility. In order to succeed in this hermeneutic and investigative process, the literature review will be used as methodological procedure, based on the following authors: Lemos (2007a, 2007b, 2008, 2009), Rivière (2006) and Tuan (2003). The intention is not only to discuss the implications between mobility and mass communication, the configuration process and informational territory’s reconfiguration, but also to empower the co-enunciator to become a “bricoleur” of the transmodernity, make possible to discuss the concept of identity in the contemporary society and, thus, to resignify his look at the time he is part of, collaborating in the building process of new ways of establishing links and the belonging feeling.
KEYWORDS: informational mobility; unplugged cities; individuation; subjectivation.
Mídia pós-massiva: um levantamento de podcast especializado em meio ambiente como instrumento de conscientização ambiental
Authors: Santos Arantxa Carla da Silva , Paes Renata da Cruz , Pontes Altem Nascimento 
Published: May 2019

RESUMO: O intuito deste artigo é realizar um mapeamento dos podcasts existentes no Brasil e que são utilizados como ferramenta para disseminação de temas voltados ao meio ambiente. Para tanto, foi analisado o uso desse modelo de mídia de comunicação e o seu fator de conscientização ambiental. Em termos metodológicos, a pesquisa foi qualiquantitativa e exploratória, consistindo no levantamento de 20 podcasts de acesso gratuito e disponíveis na web. Foram contabilizados 1.189 episódios divididos desigualmente entre 20 podcasts. A partir da Análise de Conteúdo (AC), identificou-se que a maioria dos podcasts é produzido em São Paulo e surgiu no ano de 2018. Eles são publicados semanalmente e a maioria em formato de entrevista. Notou-se ainda que o tema ambiental de maior ocorrência é sustentabilidade. Apesar de esta mídia ser relativamente recente, especialmente no Brasil, os podcasts têm se disseminado e instigado debates sobre o meio ambiente, inclusive no que se refere à Amazônia, que é, entretanto, temática ainda pouco discutida nessa plataforma digital.
PALAVRAS-CHAVE: comunicação; internet; áudio; cibercultura.

ABSTRACT: The purpose of this article is to map the podcasts that exist in Brazil and are used as a tool to disseminate themes focused on the environment. For this, the use of this communication media model and its environmental awareness factor was analyzed. In methodological terms, the research was qualitative and exploratory, consisting of the survey of 20 podcasts of free access and available on the web. There were 1,189 episodes divided unequally between 20 podcasts. Anchored in the Content Analysis, it was identified that most podcasts are produced in São Paulo and emerged in the year 2018. They are published weekly, and most of them have the content based on interviews. It was also noted that the environmental theme of greatest occurrence is sustainability. Although this media is relatively recent, especially in Brazil, podcasts have disseminated and instigated debates about the environment, including about the Amazon, but it is still little discussed in this digital platform.
KEYWORDS: communication; internet; audio; cyberculture.
Diseño y uso de una aplicación web para el campo de la estadística considerando el modelo ASSURE y la ciencia de datos
Authors: Salas-Rueda Ricardo-Adán , Salas-Rueda Érika-Patricia , Salas-Rueda Rodrigo-David 
Published: May 2019

RESUMEN: Esta investigación mixta tiene como objetivo analizar el impacto de laAplicación web para el Proceso Educativo sobre la Prueba de Hipótesis (APEPH)en la asignatura Instrumentación estadística para los negocios durante el ciclo escolar 2018. El modelo instruccional ASSURE permite la organización, construcción e implementación de la aplicación APEPH. Los resultados del aprendizaje automático (regresión lineal) con 60%, 70% y 80% de entrenamiento indican que el contenido, el diseño web y la simulación de datos en la aplicación APEPH influyen positivamente en el aprendizaje y la motivación del estudiante. Asimismo, la ciencia de datos permite la construcción de 6 modelos predictivos sobre el uso de la aplicación APEPH en el proceso educativo por medio de la técnica árbol de decisión. Por último, la aplicación APEPH facilita el proceso de enseñanza-aprendizaje sobre la estadística por medio del contenido, el diseño web y la simulación de datos.
PALABRAS CLAVE: tecnología educativa; modelo ASSURE; enseñanza superior; ciencia de datos; aprendizaje automático.

ABSTRACT:
This mixed research aims at analyzing the impact of the Web Application for the Educational Process on the Hypothesis Test (APEPH) in the Statistical Instrumentation for Business subject during the 2018 school year. ASSURE model allows the organization, construction and implementation of the APEPH application. The results of machine learning (linear regression) with 60%, 70% and 80% of training indicate that the content, web design and simulation of data in the APEPH application have a positive influence on the student's learning and motivation. Likewise, data science allows the construction of 6 predictive models on the use of the APEPH application in the educational process by means of the decision tree technique. Finally, the APEPH application facilitates the teaching-learning process on statistics through the content, web design and data simulation.
KEYWORDS: educational technology; ASSURE model; higher education; data science; machine learning.