bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gone in 60 seconds: Sub-lethal Effects of Metofluthrin Vapors on Behavior and Fitness of Resistant and Field Strains of Aedes aegypti (Diptera: Culicidae)
Authors: Bibbs Christopher S , Bloomquist Jeffrey R , Hahn Daniel A , Kaufman Phillip E , Xue Rui-De 
Published: April 2019

Abstract
Spatial repellents can reduce fecundity and interrupt oviposition behavior in Aedes aegypti. Yet, it is unclear if short exposure times, resistant phenotypes, and other aspects of spatial repellents can impact these effects on mosquito reproduction. To address these issues, pyrethroid susceptible, pyrethroid resistant, and field strains of Ae. aegypti were used to evaluate the extent to which fecundity and oviposition behavior are affected following metofluthrin exposure. Mosquitoes were exposed for 60 s to a sub-lethal dose (LC30) of metofluthrin before blood feeding and allowed 72 h to become gravid before evaluation in an oviposition bioassay for an additional 72 h. Metofluthrin-exposed susceptible, field, and to a lesser extent resistant strain Ae. aegypti showed oviposition across fewer containers, less egg yield, less egg viability, and reduced larval survivorship in hatched eggs compared to unexposed cohorts. Susceptible mosquitoes retained some eggs at dissection following bioassays, and in one case, melanized eggs retained in the female. Treated resistant and field strain F1 larvae hatched significantly earlier than unexposed cohorts and resulted in increased larval mortality in the first 3 d after oviposition. Upon laying, the treated field strain had incompletely melanized eggs mixed in with viable eggs. The treated field strain also had the lowest survivorship of larvae reared from bioassay eggs. These results indicate that metofluthrin could succeed in reducing mosquito populations via multiple mechanisms besides acute lethality. With the available safety data, pre-existing spatial repellent registration, and possibilities for other outdoor delivery methods, metofluthrin is a strong candidate for transition into broader mosquito abatement operations.
Establishment of mixed plantations of Pinus sylvestris var. mongolica and Populus × xiaozhuanica may not be appropriate: evidence from litter decomposition
Authors: Song Huan-Huan , Yan Tao , Zeng De-Hui 
Published: April 2019

Abstract

Aims
Mongolian pine (Pinus sylvestris var. mongolica) and Xiaozhuan poplar (Populus × xiaozhuanica) are two predominant afforestation tree species in the semi-arid sandy lands of northeast China, which are characterized by poor soil nutrients. Plant litter decomposition plays a critical role in regulating nutrient cycling in terrestrial ecosystems. Admixture of broadleaf litter to conifer litter is expected to improve litter decomposition and soil fertility, and thus productivity. However, the effects on the decomposition of litter mixture of the above two tree species are not well understood. Therefore, it is essential to assess the decomposition performance of litter mixture with the aim of improving forest nutrient management and the establishment of mixed plantation. Appropriate forest management practice is critical for the sustainability of site productivity in plantation forests.

Methods
We conducted a field litterbag decomposition transplant experiment for single pine litter, single poplar litter and their mixture in a pine stand, a poplar stand and an adjacent grassland for 16 months in the Keerqin Sandy Lands, northeast China.

Important Findings
After 16 months of incubation, there remained significantly more litter mass of pine (73.8%) than of poplar (67.2%). The mass remaining was positively correlated with litter carbon (C):nitrogen (N), C:phosphorus (P) and lignin:N ratios, and negatively with litter N and P concentrations, which suggests that initial litter chemical properties were an important factor affecting litter decay. Generally, net N and P immobilizations were observed during decomposition. This indicates that litter decomposition in this area was N-limited as N was progressively immobilized, and then tended to induce P limitation. Thus, we strongly recommend prohibiting litter harvesting by local residents to maintain soil fertility in this nutrient-poor area. Our results do not support the home-field advantage hypothesis, as illustrated by the fact that, in most cases, mass loss of litter from native habitat was comparable to that in transplanted habitats during decomposition. Furthermore, a dominant additive effect was detected, indicating that the establishment of mixed plantation may not be appropriate for these two species.
Misreporting Among Reluctant Respondents
Authors: Bach Ruben L , Eckman Stephanie , Daikeler Jessica 
Published: April 2019

AbstractMany surveys aim to achieve high response rates to keep bias due to nonresponse low. However, research has shown that the relationship between the nonresponse rate and nonresponse bias is small. In fact, high response rates may lead to measurement error, if respondents with low response propensities provide survey responses of low quality. In this paper, we explore the relationship between response propensity and measurement error, specifically, motivated misreporting, the tendency to give inaccurate answers to speed through an interview. Using data from four surveys conducted in several countries and modes, we analyze whether motivated misreporting is worse among those respondents who were the least likely to respond to the survey. Contrary to the prediction of our theoretical model, we find only limited evidence that reluctant respondents are more likely to misreport.
Tiny grains shining bright in the gaps of Herbig Ae transitional discs
Authors: Birchall Eloise K , Ireland Michael J , Federrath Christoph , Monnier John D , Kraus Stefan , Willson Matthew , Kraus Adam L , Rizzuto Aaron , Agnew Matthew T , Maddison Sarah T 
Published: April 2019

ABSTRACT
This work presents a study of two Herbig Ae transitional discs, Oph IRS 48 and HD 169142; which both have reported rings in their dust density distributions. We use Keck-II/NIRC2 adaptive optics imaging observations in the L′ filter (3.8 $\mu$m) to probe the regions of these discs inwards of ${\sim }20\, \mathrm{au}$ from the star. We introduce our method for investigating these transitional discs, which takes a forward modelling approach: making a model of the disc (using the Monte Carlo radiative transfer code radmc3d), convolving it with point spread functions of calibrator stars, and comparing the convolved models with the observational data. The disc surface density parameters are explored with a Monte Carlo Markov Chain technique. Our analysis recovers emission from both of the discs interior to the well-known optically thick walls, modelled as a ring of emission at ${\sim }15\, \mathrm{au}$ in Oph IRS 48, and ${\sim }7\, \mathrm{au}$ for HD 169142, and identifies asymmetries in both discs. Given the brightness of the near-symmetric rings compared to the reported companion candidates, we suggest that the reported companion candidates can be interpreted as slightly asymmetric disc emission or illumination.
Predictably missing satellites: subhalo abundances in Milky Way-like haloes
Authors: Fielder Catherine E , Mao Yao-Yuan , Newman Jeffrey A , Zentner Andrew R , Licquia Timothy C 
Published: April 2019

ABSTRACT
On small scales there have been a number of claims of discrepancies between the standard cold dark matter (CDM) model and observations. The ‘missing satellites problem’ infamously describes the overabundance of subhaloes from CDM simulations compared to the number of satellites observed in the Milky Way. A variety of solutions to this discrepancy have been proposed; however, the impact of the specific properties of the Milky Way halo relative to the typical halo of its mass has yet to be explored. Motivated by recent studies that identified ways in which the Milky Way is atypical, we investigate how the properties of dark matter haloes with mass comparable to our Galaxy’s – including concentration, spin, shape, and scale factor of the last major merger – correlate with the subhalo abundance. Using zoom-in simulations of Milky Way-like haloes, we build two models of subhalo abundance as functions of host halo properties. From these models we conclude that the Milky Way most likely has fewer subhaloes than the average halo of the same mass. We expect up to 30 per cent fewer subhaloes with low maximum rotation velocities ($V_{\rm max}^{\rm sat} \sim 10$ km s−1) at the 68 per cent confidence level and up to 52 per cent fewer than average subhaloes with high rotation velocities ($V_{\rm max}^{\rm sat} \gtrsim 30$ km s−1, comparable to the Magellanic Clouds) than would be expected for a typical halo of the Milky Way’s mass. Concentration is the most informative single parameter for predicting subhalo abundance. Our results imply that models tuned to explain the missing satellites problem assuming typical subhalo abundances for our Galaxy may be overcorrecting.
The footprint of cometary dust analogues – II. Morphology as a tracer of tensile strength and application to dust collection by the Rosetta spacecraft
Authors: Ellerbroek L E , Gundlach B , Landeck A , Dominik C , Blum J , Merouane S , Hilchenbach M , John H , van Veen H A 
Published: April 2019

ABSTRACT
The structure of cometary dust is a tracer of growth processes in the formation of planetesimals. Instrumentation on board the Rosetta mission to comet 67P/Churyumov–Gerasimenko captured dust particles and analysed them in situ. However, these deposits are a product of a collision within the instrument. We conducted laboratory experiments with cometary dust analogues, simulating the collection process by Rosetta instruments (specifically COSIMA, MIDAS). In Paper I, we reported that velocity is a key driver in determining the appearance of deposits. Here in Paper II, we use materials with different monomer sizes, and study the effect of tensile strength on the appearance of deposits. We find that mass transfer efficiency increases from ∼1 up to ∼10 per cent with increasing monomer diameter from 0.3 to 1.5 $\mu\mathrm{ m}$ (i.e. tensile strength decreasing from ∼12 to ∼3 kPa), and velocities increasing from 0.5 to 6 m s−1. Also, the relative abundance of small fragments after impact is higher for material with higher tensile strength. The degeneracy between the effects of velocity and material strength may be lifted by performing a closer study of the deposits. This experimental method makes it possible to estimate the mass transfer efficiency in the COSIMA instrument. Extrapolating these results implies that more than half of the dust collected during the Rosetta mission has not been imaged. We analysed two COSIMA targets containing deposits from single collisions. The collision that occurred closest to perihelion passage led to more small fragments on the target.
TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA
Authors: Li You , Wang Li , Rivera-Serrano Efraín E , Chen Xian , Lemon Stanley M 
Published: April 2019

AbstractThe liver-specific microRNA, miR-122, is an essential host factor for replication of the hepatitis C virus (HCV). miR-122 stabilizes the positive-strand HCV RNA genome and promotes its synthesis by binding two sites (S1 and S2) near its 5′ end in association with Ago2. Ago2 is essential for both host factor activities, but whether other host proteins are involved is unknown. Using an unbiased quantitative proteomics screen, we identified the TNRC6 protein paralogs, TNRC6B and TNRC6C, as functionally important but redundant components of the miR-122/Ago2 host factor complex. Doubly depleting TNRC6B and TNRC6C proteins reduced HCV replication in human hepatoma cells, dampening miR-122 stimulation of viral RNA synthesis without reducing the stability or translational activity of the viral RNA. TNRC6B/C were required for optimal miR-122 host factor activity only when S1 was able to bind miR-122, and restricted replication when S1 was mutated and only S2 bound by miR-122. TNRC6B/C preferentially associated with S1, and TNRC6B/C depletion enhanced Ago2 association at S2. Collectively, these data suggest a model in which TNRC6B/C regulate the assembly of miR-122/Ago complexes on HCV RNA, preferentially directing miR-122/Ago2 to S1 while restricting its association with S2, thereby fine-tuning the spatial organization of miR-122/Ago2 complexes on the viral genome.
Bacterial genome architecture shapes global transcriptional regulation by DNA supercoiling
Authors: El Houdaigui Bilal , Forquet Raphaël , Hindré Thomas , Schneider Dominique , Nasser William , Reverchon Sylvie , Meyer Sam 
Published: April 2019

Abstract
DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an important role in adapting their expression programme to environmental changes, but for which no quantitative or even qualitative regulatory model is available. Here, we focus on spatial supercoiling heterogeneities caused by the transcription process itself, which strongly contribute to this regulation mode. We propose a new mechanistic modeling of the transcription-supercoiling dynamical coupling along a genome, which allows simulating and quantitatively reproducing in vitro and in vivo transcription assays, and highlights the role of genes’ local orientation in their supercoiling sensitivity. Consistently with predictions, we show that chromosomal relaxation artificially induced by gyrase inhibitors selectively activates convergent genes in several enterobacteria, while conversely, an increase in DNA supercoiling naturally selected in a long-term evolution experiment with Escherichia coli favours divergent genes. Simulations show that these global expression responses to changes in DNA supercoiling result from fundamental mechanical constraints imposed by transcription, independently from more specific regulation of each promoter. These constraints underpin a significant and predictable contribution to the complex rules by which bacteria use DNA supercoiling as a global but fine-tuned transcriptional regulator.
Research on Youth and Young Adult Tobacco Use, 2013–2018, From the Food and Drug Administration–National Institutes of Health Tobacco Centers of Regulatory Science
Authors: Perry Cheryl L , Creamer MeLisa R , Chaffee Benjamin W , Unger Jennifer B , Sutfin Erin L , Kong Grace , Shang Ce , Clendennen Stephanie L , Krishnan-Sarin Suchitra , Pentz Mary Ann 
Published: April 2019

Abstract

The Tobacco Regulatory Science Program is a collaborative research effort between the National Institutes of Health (NIH) and the Food and Drug Administration (FDA). In 2013, the NIH funded 14 Tobacco Centers of Regulatory Science (TCORS), which serve as partners in establishing research, training, and professional development programs to guide FDA. Each of the fourteen TCORS, and two other NIH-funded research programs, the Center for the Evaluation of Nicotine in Cigarettes (CENIC) and the Consortium on Methods Evaluating Tobacco (COMET), pursued specific research themes relevant to FDA’s priorities. A key mandate for FDA is to reduce tobacco use among young people. This article is a review of the peer-reviewed research, including published and in-press manuscripts, from the TCORS, CENIC, and COMET, which provides specific data or other findings on youth (ages 10–18 years) and/or young adults (ages 18–34 years), from 2013 to 2018. Citations of all TCORS, CENIC, and COMET articles from September 2013 to December 2017 were collected by the TCORS coordinating center, the Center for Evaluation and Coordination of Training and Research. Additional citations up to April 30, 2018 were requested from the principal investigators. A scoring rubric was developed and implemented to assess study type, primary theme, and FDA priority area addressed by each article. The major subareas and findings from each priority area are presented. There were 766 articles in total, with 258 (34%) focusing on youth and/or young adults. Findings relevant to FDA from this review concern impact analysis, toxicity, health effects, addiction, marketing influences, communications, and behavior.

Implications
The Tobacco Centers of Regulatory Science, CENIC, and COMET have had a high output of scientific articles since 2013. These Centers are unique in that the FDA supports science specifically to guide future regulatory actions. The 258 articles that have focused on youth and/or young adults are providing data for regulatory actions by the FDA related to the key priority areas such as the addictiveness of non-cigarette products, the effects of exposure to electronic cigarette marketing on initiation and cessation, and the impact of flavored products on youth and young adult tobacco use. Future regulations to reduce tobacco use will be guided by the cumulative evidence. These Centers are one innovative mechanism to promote important outcomes to advance tobacco regulatory science.
In situ and experimental evidence for effects of elevated pH on protistan and metazoan grazers
Authors: Hansen Benni W , Andersen Christian M B , Hansen Per J , Nielsen Torkel G , Vismann Bent , Tiselius Peter 
Published: April 2019

AbstractPlankton succession was studied in a hyper-eutrophic stratified estuary, Mariager Fjord, Denmark. Above the pycnocline (15 m) pH increased from 8.5 to 9.2 and the oxygen increased to super saturation after 5 d of sunny weather due to high primary production. The protistan grazers were dominated by heterotrophic dinoflagellates and mixotrophic and heterotrophic ciliates. Metazooplankton was dominated by meroplankton, rotifers and the copepod, Acartia tonsa, all with a relatively low biomass. Cirriped nauplii occupied the upper strata while polychaete larvae populated the whole water column. Bivalve larvae occurred occasionally above the pycnocline even at very high pH. In pH challenge experiments, the mixotrophic ciliate Mesodinium rubrum was the least pH tolerant species, followed by Strombidium spp., which did not cope well with seawater pH > 8.5. Some heterotrophic dinoflagellates were more tolerant with net growth at pH > 9. The predominant rotifer Synchaeta sp. tolerated up to pH 9.5 and the copepod survived pH 10 but stopped producing eggs at pH 9.5 with unaffected egg hatching success. The polychaete and cirriped larvae tolerated pH 9.5, but bivalve larvae showed decreased survival already at pH 8.5. In situ distribution patterns and pH challenge experiments suggest that pH indeed contribute to structuring zooplankton distribution.
EVALUATION AND STATISTICAL ANALYSIS OF THE USE OF INFOGRAPHICS IN RADIOLOGY EDUCATION
Authors: Takashima Ryuta , Ito Mari , Chida Takanori , Watanabe Toshiyuki , Toyama Takahiko , Yaginuma Taira , Anzai Takahiro , Hiyama Toru , Iimoto Takeshi , Fujii Hirofumi 
Published: April 2019

Abstract
Interest in the need for systematic radiology education has increased since the Fukushima Daiichi nuclear disaster. Practice and attitude surveys on radiology education have been previously undertaken and indicate that there is currently limited quantitative knowledge on the use of radiation and radiological consequences. Although maintenance of an education system and measurements of its effects on knowledge levels have been conducted, no novel developments have been made in the methods of measurement. In this study, we measured the effect of the infographics to develop more effective educational materials and lecture methods in radiology education. In addition, we quantitatively evaluated the effects of using infographics on changes in knowledge levels using statistical analysis.
Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia
Authors: Openshaw Rebecca L , Thomson David M , Thompson Rhiannon , Penninger Josef M , Pratt Judith A , Morris Brian J , Dawson Neil 
Published: April 2019

Abstractc-Jun N-terminal kinase (JNK) signaling contributes to functional plasticity in the brain and cognition. Accumulating evidence implicates a role for MAP kinase kinase 7 (MAP2K7), a JNK activator encoded by the Map2k7 gene, and other JNK pathway components in schizophrenia (ScZ). Mice haploinsufficient for Map2k7 (Map2k7+/− mice) display ScZ-relevant cognitive deficits, although the mechanisms are unclear. Here we show that Map2k7+/− mice display translationally relevant alterations in brain function, including hippocampal and mesolimbic system hypermetabolism with a contrasting prefrontal cortex (PFC) hypometabolism, reminiscent of patients with ScZ. In addition Map2k7+/− mice show alterations in functional brain network connectivity paralleling those reported in early ScZ, including PFC and hippocampal hyperconnectivity and compromised mesolimbic system functional connectivity. We also show that although the cerebral metabolic response to ketamine is preserved, the response to dextroamphetamine (d-amphetamine) is significantly attenuated in Map2k7+/− mice, supporting monoamine neurotransmitter system dysfunction but not glutamate/NMDA receptor (NMDA-R) dysfunction as a consequence of Map2k7 haploinsufficiency. These effects are mirrored behaviorally with an attenuated impact of d-amphetamine on sensorimotor gating and locomotion, whereas similar deficits produced by ketamine are preserved, in Map2k7+/− mice. In addition, Map2k7+/− mice show a basal hyperactivity and sensorimotor gating deficit. Overall, these data suggest that Map2k7 modifies brain and monoamine neurotransmitter system function in a manner relevant to the positive and cognitive symptoms of ScZ.
Suspicious Mothering: Maternal Labor and Marriage Migration in South Korea
Authors: Yi Sohoon 
Published: April 2019

Abstract
Inspired by theories of marginalized women’s maternal labor, this article contributes to the literature on the relationship between borders and parenting in Asia. After marital breakdown, marriage migrants in South Korea can extend their stay if they have South Korean children and can present evidence of mothering to the immigration authorities. This article presents a socio-legal analysis of cross-border mothering through in-depth interviews with migrants and relevant stakeholders. Taking cross-border mothering as a site where state intervention encounters migrant subjectivity, I examine maternal norms and scrutiny imposed by immigration authorities and performative maternal labor of migrant mothers.