bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Abacus: Instruction by Teachers of Students with Visual Impairments
Authors: Amato Sheila , Hong Sunggye , Rosenblum L. Penny 
Published: January 2019

Introduction This article, based on a study of 196 teachers of students with visual impairments, reports on the experiences with and opinions related to their decisions about instructing their students who are blind or have low vision in the abacus. Methods The participants completed an online survey on how they decide which students should be taught abacus computation skills and which skills they teach. Data were also gathered on those who reported that they did not teach computation with the abacus. Results The participants resided in the United States and Canada and had various numbers of years of teaching experience. More than two-thirds of those who reported that they taught abacus computation skills indicated that they began instruction when their students were between preschool and the second grade. When students were provided with instruction in abacus computation, the most frequently taught skills were the operations of addition and subtraction. More than two-thirds of the participants reported that students were allowed to use an abacus on high-stakes tests in their state or province. Discussion Teachers of students with visual impairments are teaching students to compute using the Cranmer abacus. A small number of participants reported they did not teach computation with an abacus to their students because of their own lack of knowledge. Implications for practitioners The abacus has a role in the toolbox of today's students with visual impairments. Among other implications for educational practice, further studies are needed to examine more closely how teachers of students with visual impairments are instructing their students in computation with an abacus. Topics to examine include the frequency of instruction, the age at which instruction begins, how instruction is provided to children with multiple disabilities, whether instruction is provided in the general education classroom or via pullouts, the role of math teachers and paraeducators in instruction, and how the abacus could be used collaboratively with technology.
Could Audio-Described Films Benefit from Audio Introductions? An Audience Response Study
Authors: Romero-Fresco Pablo , Fryer Louise 
Published: January 2019

Introduction Time constraints limit the quantity and type of information conveyed in audio description (AD) for films, in particular the cinematic aspects. Inspired by introductory notes for theatre AD, this study developed audio introductions (AIs) for Slumdog Millionaire and Man on Wire. Each AI comprised 10 minutes of continuous description incorporating information about the film's visual style, fuller descriptions of characters and settings, a brief synopsis, and cast and production details. The AIs were tested with participants who are blind and have low vision. Method Twenty-four visually impaired volunteers listened to the AIs before or after watching the films with AD, and gave feedback about their experience, either at sessions organized at the University of Roehampton, United Kingdom, or at home. Results This was a small-scale, exploratory study that showed a positive response to the concept of AIs for film. Most participants felt the AIs helped bring the films to life and made them easier to follow. The majority of participants wanted AIs for other films. Discussion AD guidelines discourage describers from mentioning camera work, yet most participants reported that this information in the AI was not too technical, and that the proportion of the AI devoted to visual style was about right (14 of 20 for Slumdog Millionaire, 14 of 16 for Man on Wire). Only a minority felt that the AIs “told me things I could find out for myself.” This suggests that access to screen media for people with a visual impairment can be enhanced by additional cinematic and other visual information. Implications for practitioners Given the limited time available for description during the film itself, AD providers should consider the use of AIs as a complement to standard film AD. These audio introductions could be stand-alone or accessed from a website.
Balance and Self-efficacy of Balance in Children with CHARGE Syndrome
Authors: Haibach Pamela S. , Lieberman Lauren J. 
Published: January 2019

Introduction Balance is a critical component of daily living, because it affects all movements and the ability to function independently. Children with CHARGE syndrome have sensory and motor impairments that could negatively affect their balance and postural control. The purpose of the study presented in this article was to assess the balance and self-efficacy of balance of these children. Methods Twenty-one children with CHARGE syndrome aged 6-12 and 31 age- and gender-matched sighted control participants without CHARGE syndrome completed the study. Each participant completed the Pediatric Balance Scale (PBS) and a self-efficacy of balance survey, the Activities-Specific Balance Confidence Scale (ABC). Results The PBS results revealed that the participants in the control group performed significantly better than did those with CHARGE syndrome (p < .05), with 57% of those with CHARGE syndrome at a medium to high risk of falls but all those in the control group at a low risk. Most children with CHARGE syndrome also had low ABC scores, and these scores were moderately correlated with the PBS scores (r = 0.56), but were not significantly associated with gender (r = 0.065) or age (r = −0.169). Discussion A relationship was found between the balance self-efficacy of the children with CHARGE syndrome and their objectively measured balance. Self-efficacy of balance has been correlated with an increased risk of falls and with decreased participation in physical activities. Increased physical activity with a focus on balance and movement would likely improve these children's balance and self-efficacy of balance. Implications for practitioners Practitioners should understand that children with CHARGE syndrome will likely have poorer balance and lower confidence in their balance. Balance confidence and capabilities have implications for the development of motor milestones, such as walking, and the ability to perform functional activities. Future research should examine interventions to improve both balance and confidence in balance in these children.
Working with Visual Impairment in Nigeria: A Qualitative Look at Employment Status
Authors: Wolffe Karen E. , Ajuwon Paul M. , Kelly Stacy M. 
Published: January 2019

Introduction This study presents the perceptions of employed individuals with visual impairments living in one of the world's most populous developing nations, Nigeria. Methods The researchers developed a questionnaire that assessed personal and professional experiences among a sample of 172 adults with visual impairments living and working in Nigeria. Qualitative analyses of all the participants’ responses to open-ended questions on the questionnaire were performed; as well as an analysis of responses from a subset of the participants who engaged in face-to-face interviews. Results Participants identified out-of-date or inaccessible equipment and materials, coupled with inadequate assistance, transportation issues and environmental barriers, poor remuneration, weak job status, discrimination, lack of funds or time, inaccessible housing, and limited training opportunities as work challenges. The majority felt that further education was the key to improving their work situations. Discussion This study validated the findings of the quantitative study with which it was aligned, underscoring the importance of education and access to employment for people with visual impairments. The participants in this study conveyed their thoughts about what worked and what did not work for them in employment. They also shared their ideas about how parental support had enabled them to achieve employment, and stressed the importance of disability-specific skills such as using assistive technology, mobility techniques, and independent living skills. Implications for practitioners Practitioners are reminded of the importance of working closely with families to help them help their children acquire skills and the belief that they can work. They also need to remember the critical need for their students and clients to master disability-specific skills.
Social Skills for Youths with Visual Impairments: A Meta-Analysis
Authors: Botsford Kathryn D. 
Published: January 2019

Introduction This meta-analysis reviewed correlational research on youths (ages 13–21) with visual impairments (that is, blindness or low vision) conducted using the National Longitudinal Transition Study-2 (NLTS2). Methods After a systematic literature review, six studies (four peer-reviewed articles, one dissertation, and one conference presentation) met inclusionary criteria and provided sufficient findings for meta-analysis. Three studies were selected to represent NLTS2 Waves 1, 3, and 4 without violating assumptions of independence. The fixed-effect meta-analysis tested the summary effect of social skills variables. Results Social skills had a moderate summary effect (r2 = .373), with high precision for an aggregated sample of 1,229 youths. The test for heterogeneity (I2 = 94.25) indicated that social skills explained 6% of the between-study findings. Cumulative analysis suggested a small amount of publication bias. Discussion Although differences other than social skills accounted for most between-study variances, trends in the research imply relationships between social skills and the Expanded Core Curriculum (ECC). Implications for practitioners Given the limited time available for specialized instruction, identifying ECC areas with measurable positive impacts empowers teachers to design effective programs. The moderate positive overall effect for social skills variables reported in this study supports the continued emphasis on social competence in the educational programs for youths with visual impairments. Given the challenges with conducting research using small samples in the field of visual impairment, meta-analysis offers opportunities to test the overall effect of interventions by combining the findings of multiple smaller studies. This study demonstrated that meta-analytic research is applicable to the field of visual impairment. Future meta-analytic studies of any ECC variables would benefit from the inclusion of additional sources of quantitative research (that is, intervention studies and different large-scale datasets). New research from a variety of data sources would allow the field to more clearly describe trends and relationships among ECC variables and transition outcomes for this population.
Risk of readmission in patients with schizophrenia and schizoaffective disorder newly prescribed clozapine
Authors: Kesserwani Jad , Kadra Giouliana , Downs Johnny , Shetty Hitesh , MacCabe James H , Taylor David , Stewart Robert , Chang Chin-Kuo , Hayes Richard D 
Published: January 2019

Background: Insight into the effect of clozapine is limited by a lack of controlling for confounding variables in current research. Our objective was to investigate the association between clozapine prescribed at discharge, following an inpatient episode, and risk of readmission into secondary mental health services in patients with schizophrenia and schizoaffective disorder, controlling extensively for confounding variables. Methods: Clinical records from 3651 patients were analysed in a retrospective observational cohort study. Cox proportional-hazards regression models were used to assess the risk of hospital readmission. A series of sensitivity analyses were also conducted. Propensity score methods were used to address confounding-by-indication. Results: Patients on clozapine ( n=202) had a reduced risk of readmission compared with patients on other antipsychotics (adjusted hazard ratio=0.79; 95% confidence interval: 0.64–0.99; p=0.043). Clozapine also had a protective effect on risk of readmission when compared with olanzapine (adjusted hazard ratio 0.76; 95% confidence interval: 0.60–0.96; p=0.021). The effect size remained consistent after adjusting for an array of possible confounders, as well as using propensity scores to address confounding-by-indication. A statistically significant result was also noted in all but two sensitivity analyses. Conclusion: Our findings suggest that clozapine is associated with a reduced risk of readmission into secondary mental health services.
Expression and clinical significance of miR-139-5p in non-small cell lung cancer
Authors: Yong-hao You , Xian-guo Wang , Ming Xu , Jin-ping Zhao 
Published: January 2019

Objective MiR-139-5p is a common tumor-associated microRNA (miRNA), which inhibits the occurrence and development of malignant tumors from various tissue sources. We detected miR-139-5p expression levels in tissues from patients with non-small cell lung cancer (NSCLC) to explore the relationship between miR-139-5p expression and clinicopathological parameters. Methods MiR-139-5p expression levels were detected in cancerous and normal tissues from 60 NSCLC patients by fluorescence quantitative polymerase chain reaction, using normal paracancerous tissue as a control. The relationships between miR-139-5p and clinicopathological parameters of NSCLC, including survival, were analyzed by t-tests and univariate analysis. Results MiR-139-5p expression levels were significantly reduced in NSCLC tissues compared with normal adjacent tissue. MiR-139-5p expression was not significantly associated with age, sex, or smoking history, but was related to clinical stage, pathological type, tumor size, and lymph node metastasis. Furthermore, low expression of miR-139-5p, clinical stage (II/III), adenocarcinoma, tumor ≥3 cm, and lymph node metastasis were all related to overall survival. Conclusion MiR-139-5p expression levels are down-regulated in NSCLC tissues, and low expression is associated with clinical stage, pathological type, tumor size, and lymph node metastasis in NSCLC patients. MiR-139-5p may act as a tumor suppressor gene in the occurrence and development of NSCLC.
Liver abscesses after transcatheter arterial embolization
Authors: Arslan Muhammet , Degirmencioglu Serkan 
Published: January 2019

Objective This study aimed to evaluate the clinical features, radiological findings, risk factors, and management of liver abscesses following transcatheter arterial chemoembolization (TACE) therapy in patients with primary and metastatic liver cancer. Methods The medical records of 163 patients who were treated with TACE in our hospital for a total of 313 times between January 2012 and January 2018 were reviewed. The incidence rate of patients who developed liver abscesses after undergoing treatment, the computed tomography findings of the abscesses, predisposing risk factors, and the method of treatment were evaluated. Results Formation of liver abscesses was observed after treatment in four of the 163 (2.4%) patients and in four (1.3%) of the 313 chemoembolization procedures. Additionally, bilioenteric anastomosis was found in two patients and diabetes mellitus in two patients. Conclusion Formation of liver abscesses after TACE is a rare, but serious, complication. Physicians should be aware of the predisposing risk factors of TACE because of the possibility of death.
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Authors: Grande Bruno M. , Gerhard Daniela S. , Jiang Aixiang , Griner Nicholas B. , Abramson Jeremy S. , Alexander Thomas B. , Allen Hilary , Ayers Leona W. , Bethony Jeffrey M. , Bhatia Kishor , Bowen Jay , Casper Corey , Choi John Kim , Culibrk Luka , Davidsen Tanja M. , Dyer Maureen A. , Gastier-Foster Julie M. , Gesuwan Patee , Greiner Timothy C. , Gross Thomas G. , Hanf Benjamin , Harris Nancy Lee , He Yiwen , Irvin John D. , Jaffe Elaine S. , Jones Steven J. M. , Kerchan Patrick , Knoetze Nicole , Leal Fabio E. , Lichtenberg Tara M. , Ma Yussanne , Martin Jean Paul , Martin Marie-Reine , Mbulaiteye Sam M. , Mullighan Charles G. , Mungall Andrew J. , Namirembe Constance , Novik Karen , Noy Ariela , Ogwang Martin D. , Omoding Abraham , Orem Jackson , Reynolds Steven J. , Rushton Christopher K. , Sandlund John T. , Schmitz Roland , Taylor Cynthia , Wilson Wyndham H. , Wright George W. , Zhao Eric Y. , Marra Marco A. , Morin Ryan D. , Staudt Louis M. 
Published: January 2019

AbstractAlthough generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in more than 90% of cases in malaria-endemic regions, and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Through an integrative analysis of whole-genome and transcriptome data, we show a striking genome-wide increase in aberrant somatic hypermutation in EBV-positive tumors, supporting a link between EBV and activation-induced cytidine deaminase (AICDA) activity. In addition to identifying novel candidate BL genes such as SIN3A, USP7, and CHD8, we demonstrate that EBV-positive tumors had significantly fewer driver mutations, especially among genes with roles in apoptosis. We also found immunoglobulin variable region genes that were disproportionally used to encode clonal B-cell receptors (BCRs) in the tumors. These include IGHV4-34, known to produce autoreactive antibodies, and IGKV3-20, a feature described in other B-cell malignancies but not yet in BL. Our results suggest that tumor EBV status defines a specific BL phenotype irrespective of geographic origin, with particular molecular properties and distinct pathogenic mechanisms. The novel mutation patterns identified here imply rational use of DNA-damaging chemotherapy in some patients with BL and targeted agents such as the CDK4/6 inhibitor palbociclib in others, whereas the importance of BCR signaling in BL strengthens the potential benefit of inhibitors for PI3K, Syk, and Src family kinases among these patients.
A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data
Authors: Knapp David J. H. F. , Hammond Colin A. , Wang Fangwu , Aghaeepour Nima , Miller Paul H. , Beer Philip A. , Pellacani Davide , VanInsberghe Michael , Hansen Carl , Bendall Sean C. , Nolan Garry P. , Eaves Connie J. 
Published: January 2019

Abstract
Recent advances in single-cell molecular analytical methods and clonal growth assays are enabling more refined models of human hematopoietic lineage restriction processes to be conceptualized. Here, we report the results of integrating single-cell proteome measurements with clonally determined lymphoid, neutrophilic/monocytic, and/or erythroid progeny outputs from &gt;1000 index-sorted CD34+ human cord blood cells in short-term cultures with and without stromal cells. Surface phenotypes of functionally examined cells were individually mapped onto a molecular landscape of the entire CD34+ compartment constructed from single-cell mass cytometric measurements of 14 cell surface markers, 20 signaling/cell cycle proteins, and 6 transcription factors in ∼300 000 cells. This analysis showed that conventionally defined subsets of CD34+ cord blood cells are heterogeneous in their functional properties, transcription factor content, and signaling activities. Importantly, this molecular heterogeneity was reduced but not eliminated in phenotypes that were found to display highly restricted lineage outputs. Integration of the complete proteomic and functional data sets obtained revealed a continuous probabilistic topology of change that includes a multiplicity of lineage restriction trajectories. Each of these reflects progressive but variable changes in the levels of specific signaling intermediates and transcription factors but shared features of decreasing quiescence. Taken together, our results suggest a model in which increasingly narrowed hematopoietic output capabilities in neonatal CD34+ cord blood cells are determined by a history of external stimulation in combination with innately programmed cell state changes.
RETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression
Authors: Yang Rui , Xing Lei , Zheng Xiaying , Sun Yan , Wang Xiaosong , Chen Junxia 
Published: January 2019

Abstract
Background
In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanisms of circRNAs in triple-negative breast cancer (TNBC) still remain largely unknown.

Methods
Here, the expression profile of circRNAs in 4 pairs of TNBC tissues and adjacent non-tumor tissues was analyzed by RNA-sequencing. Quantitative real-time PCR and in situ hybridization were used to determine the level and prognostic values of circAGFG1 in two TNBC cohorts. Then, functional experiments in vitro and in vivo were performed to investigate the effects of circAGFG1 on tumor growth and metastasis in TNBC. Mechanistically, fluorescent in situ hybridization, dual luciferase reporter assay, RNA pull-down and RNA immunoprecipitation experiments were performed to confirm the interaction between circAGFG1 and miR-195-5p in TNBC.

Results
We found that circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinical stage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 could promote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo. Mechanistic analysis showed that circAGFG1 may act as a ceRNA (competing endogenous RNA) of miR-195-5p to relieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).

Conclusions
Our findings suggest that circAGFG1 promotes TNBC progression through circAGFG1/miR-195-5p/CCNE1 axis and it may serve as a new diagnostic marker or target for treatment of TNBC patients.
Determination of formation shear attenuation from dipole sonic log data
Authors: Qi Qiaomu , Cheng Arthur C. H. , Li Yunyue Elita 
Published: January 2019

ABSTRACT Formation S-wave attenuation, when combined with compressional attenuation, serves as a potential hydrocarbon indicator for seismic reservoir characterization. Sonic flexural wave measurements provide a direct means for obtaining the in situ S-wave attenuation at log scale. The key characteristic of the flexural wave is that it propagates at the formation shear slowness and experiences shear attenuation at low frequency. However, in a fast formation, the dipole log consists of refracted P- and S-waves in addition to the flexural wave. The refracted P-wave arrives early and can be removed from the dipole waveforms through time windowing. However, the refracted S-wave, which is often embedded in the flexural wave packet, is difficult to separate from the dipole waveforms. The additional energy loss associated with the refracted S-wave results in the estimated dipole attenuation being higher than the shear attenuation at low frequency. To address this issue, we have developed a new method for accurately determining the formation shear attenuation from the dipole sonic log data. The method uses a multifrequency inversion of the frequency-dependent flexural wave attenuation based on energy partitioning. We first developed our method using synthetic data. Application to field data results in a shear attenuation log that is consistent with lithologic interpretation of other available logs.