bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential plastic changes in synthesis and binding in the mouse somatostatin system after electroconvulsive stimulation
Authors: Olesen Mikkel Vestergaard , Gøtzsche Casper René , Christiansen Søren Hofman , Woldbye David Paul Drucker 
Published: March 2018

ObjectiveElectroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects. However, little is known about how ECS might affect the SST receptor system. The present study examined effects of single and repeated ECS on the synthesis of SST receptors (SSTR1–4) and SST, and SST receptor binding ([125I]LTT-SST28) in mouse hippocampal regions and piriform/parietal cortices.ResultsA complex pattern of plastic changes was observed. In the dentate gyrus, SST and SSTR1 expression and the number of hilar SST immunoreactive cells were significantly increased at 1 week after repeated ECS while SSTR2 expression was downregulated by single ECS, and SSTR3 mRNA and SST binding were elevated 24 h after repeated ECS. In hippocampal CA1 and parietal/piriform cortices, we found elevated SST mRNA levels 1 week after repeated ECS and elevated SST binding after single ECS and 24 h after repeated ECS. In hippocampal CA3, repeated ECS increased SST expression 1 week after and SST binding 24 h after. In the parietal cortex, SSTR2 mRNA expression was downregulated after single ECS while SSTR4 mRNA expression was upregulated 24 h after repeated ECS.ConclusionConsidering the known anticonvulsant effects of SST, it is likely that these ECS-induced neuroplastic changes in the SST system could participate in modulating neuronal excitability and potentially contribute to therapeutic effects of ECT.
Spinosity, regeneration, and targeting among Paleozoic crinoids and their predators
Authors: Syverson Valerie J. P. , Brett Carlton E. , Gahn Forest J. , Baumiller Tomasz K. 
Published: March 2018

AbstractEvolving interactions between predators and prey constitute one of the major adaptive influences on marine animals during the Paleozoic. Crinoids and fish constitute a predator–prey system that may date back to at least the Silurian, as suggested by patterns of crinoid regeneration and spinosity in concert with changes in the predatory fauna. Here we present data on the frequency of breakage and regeneration in the spines of the Middle Devonian camerateGennaeocrinusand late Paleozoic cladids, as well as an expanded survey of the prevalence of spinosity and infestation by platyceratid gastropods on crinoid genera during the Paleozoic. Spine regeneration frequency in the measured populations is comparable to arm regeneration frequencies from MississippianRhodocrinitesand from modern deep-water crinoid populations. The prevalence of spinosity varies by taxon, time, and anatomy among Paleozoic crinoids; notably, spinosity in camerates increased from the Silurian through the Mississippian and decreased sharply during the Pennsylvanian, whereas spines were uncommon in cladids until their Late Mississippian diversification. Among camerates, tegmen spinosity is positively correlated with the presence of infesting platyceratid gastropods. These results allow us to evaluate several hypotheses for the effects of predation on morphological differences between early, middle, and late Paleozoic crinoid faunas. Our data corroborate the hypothesis that predators targeted epibionts on camerate crinoids and anal sacs on advanced cladids and suggest that the replacement of shearing predators by crushing predators after the Hangenberg extinction affected the locations of spines in Mississippian camerates.
The modulating role of traits on the biogeographic dynamics of chondrichthyans from the Neogene to the present
Authors: Villafaña Jaime A. , Rivadeneira Marcelo M. 
Published: March 2018

AbstractThe environmental transformations that occurred during the Neogene had profound effects on spatiotemporal biodiversity patterns, yet the modulating role of traits (i.e., physiological, ecological, and life-history traits) remains little understood. We tested this idea using the Neogene fossil record of chondrichthyans along the temperate Pacific coast of South America (TPSA). Information for georeferenced occurrences and ecological and life-history information of 38 chondrichthyan fossil genera in 42 Neogene sites was collected. Global georeferenced records were used to estimate present-day biogeographic distributions of the genera and to characterize the range of oceanographic conditions in which each genus lives as a proxy of their realized niche. Biogeographic range shifts (Neogene–present) were evaluated at regional and local scales. The role of traits as drivers of different range dynamics was evaluated using random forest models. The magnitude and direction of biogeographic range shifts were different at both spatial scales. At a regional scale, 34% of genera contracted their ranges, disappearing from the TPSA. At a local scale, a similar proportion of genera expanded and contracted their southern endpoints of distribution. The models showed a high precision at both spatial scales of analyses, but the relative importance of predictor variables differed. At a regional scale, disappearing genera tended to have a higher tolerance to salinity, lower sea surface temperature (SST) range, and smaller body sizes. At a local scale, genera contracting their ranges tended to live at greater depths, tolerate lower levels of primary productivity, and show a reduced tolerance to higher and lower SST ranges. The magnitude and direction of the changes in the range distribution were scale dependent and variable across the genera. Hence, multiple environmental exogenous factors interacted with taxon traits during the Neogene, creating a mosaic of biogeographic dynamics.
Radiocarbon Measurements of Small-Size Foraminiferal Samples with the Mini Carbon Dating System (MICADAS) at the University of Bern: Implications for Paleoclimate Reconstructions
Authors: Gottschalk Julia , Szidat Sönke , Michel Elisabeth , Mazaud Alain , Salazar Gary , Battaglia Michael , Lippold Jörg , Jaccard Samuel L 
Published: March 2018

ABSTRACTRadiocarbon (14C) measurements of foraminifera often provide the only absolute age constraints in marine sediments. However, they are often challenging as their reliability and accuracy can be compromised by reduced availability of adequate sample material. New analytical advances using the MIni CArbon DAting System (MICADAS) allow 14C dating of very small samples, circumventing size limitations inherent to conventional 14C measurements with accelerator mass spectrometry (AMS). Here we use foraminiferal samples and carbonate standard material to assess the reproducibility and precision of MICADAS 14C analyses, quantify contamination biases, and determine foraminiferal 14C blank levels. The reproducibility of conventional 14C ages for our planktic (benthic) foraminiferal samples from gas measurements is 200 (130) yr, and has good precision as illustrated by the agreement between both standards and their reference values as well as between small gas- and larger graphitized foraminiferal samples (within 100±60 yr). We observe a constant contamination bias and slightly higher 14C blanks for foraminifera than for carbonate reference materials, limiting gas (graphite) 14C age determinations for foraminifera from our study sites to ~38 (~42) kyr. Our findings underline the significance of MICADAS gas analyses for 14C on smaller-than-conventional sized foraminiferal samples for paleoclimate reconstructions and dating.
A survey of formation control and motion planning of multiple unmanned vehicles
Authors: Liu Yuanchang , Bucknall Richard 
Published: March 2018

SUMMARYThe increasing deployment of multiple unmanned vehicles systems has generated large research interest in recent decades. This paper therefore provides a detailed survey to review a range of techniques related to the operation of multi-vehicle systems in different environmental domains, including land based, aerospace and marine with the specific focuses placed on formation control and cooperative motion planning. Differing from other related papers, this paper pays a special attention to the collision avoidance problem and specifically discusses and reviews those methods that adopt flexible formation shape to achieve collision avoidance for multi-vehicle systems. In the conclusions, some open research areas with suggested technologies have been proposed to facilitate the future research development.
Overlap in avian communities produces unimodal richness peaks on Bornean mountains
Authors: Burner Ryan C. , Styring Alison R. , Boer Chandradewana , Sheldon Frederick H. 
Published: March 2018

Abstract:Altitudinal gradients provide tractable, replicated systems in which to study changes in species richness and community composition over relatively short distances. Previously, richness was often assumed to follow a monotonic decline with altitude, but recent meta-analyses show that more complex patterns, including mid-altitude richness peaks, are also prevalent in birds. In this study, we used point counts to survey birds at multiple altitudes on three mountains on the island of Borneo in Sundaland, an area for which quantitative analyses of avian altitudinal distribution are unavailable. In total we conducted 1088 point counts and collected associated habitat data at 527 locations to estimate species richness by altitude on Mt Mulu (2376 m), Mt Pueh (1550 m) and Mt Topap Oso (1450 m). On Mulu, the only mountain with an intact habitat gradient, bird species richness peaks at 600 m. Richness appeared to peak at 600 m on Totap Oso as well, but on Pueh it peaked several hundred metres higher. The richness peak on Mulu differs from that predicted by null models and is instead caused by the overlap of distinct lowland and montane avifaunas, supporting the faunal overlap hypothesis. This finding provides further evidence that a lack of coincidence between peak turnover and peak richness is not sufficient evidence to rule out faunal overlap as a causal factor.
Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture
Authors: Sugawara Junichi , Iwama Noriyuki , Hoshiai Tetsuro , Tokunaga Hideki , Nishigori Hidekazu , Metoki Hirohito , Okamura Kunihiro , Yaegashi Nobuo 
Published: March 2018

AbstractObjectivesThis study was aimed to analyze post-disaster birth outcomes in coastal and inland regions of Miyagi Prefecture, Japan.MethodsPrimary data sets were compiled from birth records of obstetric facilities and 12,808 patients were analyzed for baseline birth outcomes by region. Regional risk analysis of the low-birth-weight rate and premature birth rate were conducted using multi-level logistic regression analysis.ResultsFrom overall baseline birth outcomes, a preterm birth rate was 4.6% and low-birth-weight rate was 8.8%. Regional analysis revealed that a preterm birth rate was 3.2% (coastal) and 5.0% (inland), respectively, and the rate of low birth weight was 6.5% in the coastal and 8.5% in the inland region. In the risk analysis of low-birth-weight rate and preterm birth rate, the risk in the coastal region could not be considered any higher than in the inland region (adjusted odds ratio 0.91 [0.73-1.14] and 0.85 [0.46-1.59], respectively).ConclusionsThe incidence of preterm birth and low birth weight were not adversely affected by the disaster. Early transfer and intensive medical intervention may have led to those findings. Further survey will be necessary to determine the long-term effects in both mothers and children.SugawaraJ, IwamaN, HoshiaiT, TokunagaH, NishigoriH, MetokiH, OkamuraK, YaegashiN. Regional birth outcomes after the 2011 Great East Japan Earthquake and tsunami in Miyagi Prefecture. Prehosp Disaster Med. 2018;33(2):215–219.
Prioritization of the essentials in the spending patterns of Canadian households experiencing food insecurity
Authors: Fafard St-Germain Andrée-Anne , Tarasuk Valerie 
Published: March 2018

AbstractObjectiveFood insecurity is a potent determinant of health and indicator of material deprivation in many affluent countries. Food insecurity is associated with compromises in food and housing expenditures, but how it relates to other expenditures is unknown. The present study described households’ resource allocation over a 12-month period by food insecurity status.DesignExpenditure data from the 2010 Survey of Household Spending were aggregated into four categories (basic needs, other necessities, discretionary, investments/assets) and ten sub-categories (food, clothing, housing, transportation, household/personal care, health/education, leisure, miscellaneous, personal insurance/pension, durables/assets). A four-level food insecurity status was created using the adult-specific items of the Household Food Security Survey Module. Mean dollars spent and budget share by food insecurity status were estimated with generalized linear models adjusted first for household size and composition, and subsequently for after-tax income quartiles.SettingCanada.SubjectsPopulation-based sample of households from the ten provinces (n9050).ResultsFood-secure households had higher mean total expenditures than marginally, moderately and severely food-insecure households (P-trend <0·0001). As severity of food insecurity increased, households spent less on all categories and sub-categories, except transportation, but they allocated a larger budget share to basic needs and smaller shares to discretionary spending and investments/assets. The downward trends for dollars spent on basic needs and other necessities became non-significant after accounting for income, but the upward trend in the budget shares for basic needs persisted.ConclusionsThe spending patterns of food-insecure households suggest that they prioritized essential needs above all else.
Parental health behaviour predictors of childhood and adolescent dietary trajectories
Authors: Gasser Constantine E , Mensah Fiona K , Clifford Susan A , Kerr Jessica A , Wake Melissa 
Published: March 2018

AbstractObjectiveTo determine which parental health behaviours early in childhood most strongly predict whole-of-childhood dietary trajectories.DesignPopulation-based Longitudinal Study of Australian Children (LSAC, waves 1–6; 2004–2014). Exposures were parents’ fruit/vegetable consumption, alcohol, smoking and physical activity at child age 0–1 years (B Cohort) or 4–5 years (K Cohort). Outcomes, from repeated biennial short diet diaries, were group-based trajectories of (i) dietary scores and empirically derived patterns of (ii) healthful and (iii) unhealthful foods consumed, spanning ages 2–3 to 10–11 years (B Cohort) and 4–5 to 14–15 years (K Cohort). We investigated associations of baseline parental health behaviours with child dietary trajectories using multinomial logistic regression.SettingAustralian homes.SubjectsOf children, 4443 (87·0 %) from the B Cohort and 4620 (92·7 %) from the K Cohort were included in all trajectories. Multivariable analyses included 2719 to 2905 children and both parents.ResultsChildren whose primary caregiver reported the lowest fruit/vegetable consumption had markedly higher odds of belonging to the least healthy score and pattern trajectories (K Cohort: OR=8·7, 95 % CI 5·0, 15·1 and OR=8·4, 95 % CI 4·8, 14·7, respectively); associations were weaker (K Cohort: OR=2·3, 95 % CI 1·0, 5·2) for the unhealthiest pattern trajectory. Secondary caregiver fruit/vegetable associations were smaller and inconsistent. Parental alcohol, smoking and physical activity were not predictive in multivariable analyses. Results were largely replicated for the B Cohort.ConclusionsLow primary caregiver fruit/vegetable consumption increased nearly ninefold the odds of children being in the lowest intake of healthy, but only weakly predicted unhealthy, food trajectories. Healthy and unhealthy food intake may have different determinants.
LOVE CONQUERS ALL: CUPID, PHILIP V AND THE ALLEGORICAL ZARZUELA DURING THE WAR OF THE SPANISH SUCCESSION (1701–1714)
Authors: ACUÑA MARIA VIRGINIA 
Published: March 2018

ABSTRACTAn unprecedented shift in the portrayal of Cupid took place in the Spanish mythological zarzuela during the years surrounding the War of the Spanish Succession (1701–1714). For the first time ever, Cupid was depicted not as a god of chaste or erotic love, but as a god at war with other deities. And in every work, a female actor-singer, not a male performer, played the fiery but mournful character. In this article I first explore the cultural understanding of Cupid in early eighteenth-century Spain as articulated by Spanish mythographers of the era, and as seen in the earliest representations of Cupid in Spanish theatre. I then investigate the intersection of myth, allegory, war and music theatre in a case study – the zarzuelaLas nuevas armas de amor(Love's New Weapons, 1711)–suggesting that in this work Cupid functioned as an allegorical representation of the Spanish king, and that the deity's struggles for power mirrored the monarch's plight during a time of great political instability. Moreover, I argue that the pre-existing local theatrical practice of cross-dressing allowed for the portrayal of a defeated and sobbing Cupid in the zarzuela.
Migration and data protection: Doing no harm in an age of mass displacement, mass surveillance and “big data”
Authors: Hayes Ben 
Published: March 2018

AbstractThis article considers the key data protection challenges facing humanitarian organizations providing assistance to refugees, internally displaced persons and migrants. These challenges are particularly significant for several reasons: because data protection has come relatively late to the humanitarian sector; because humanitarian organizations are under pressure to innovate rapidly; because the global communications architecture on which many of these innovations depend is inherently vulnerable to State surveillance; and because States are deploying increasingly sophisticated and coercive means to prevent irregular forms of migration and/or subjecting humanitarian organizations to surveillance and disruption. The first part of the article outlines the fundamental rights challenges presented by contemporary data-driven migration control paradigms. The second outlines concerns about “data-driven humanitarianism” and “mass surveillance” to show how humanitarian organizations risk inadvertently exacerbating these problems. The third assesses specific data protection challenges that humanitarian organizations face and the policies and practices they have developed in response. The article concludes with some brief observations on the technical and political dynamics shaping their efforts to comply with their legal and ethical obligations, and calls for the sector to work together to extend data protection norms and outlaw cyber-attacks by State actors.
Precise techniques to detect superimposed radar pulses on ESM systems
Authors: G. Licursi de Mello Rafael , Rangel de Sousa Fernando 
Published: March 2018

The latest works on the radar pulse de‐interleaving in electronic support measures (ESM) systems have not completely solved the missing pulses problem yet. The authors present a pulse detection algorithm that aims at, if not eliminating it, diminishing the rate of pulses not detected because of the fact of being superimposed in other ones. Experiments set up on an ESM system based on software‐defined radio (SDR) showed that the algorithm detection rate was near a hundred per cent and the false alarm rate was near zero when pulse amplitudes were >3.9 mV in the SDR input. This work is suggested for the areas of digital and radar signal processing and electronic warfare.
Induction of Vasoactive Substances Differs in LPS-Induced and TF-Induced DIC Models in Rats
Authors: Okudaira Mariko , Yoshida Tomotaka , Ontachi Yasuo , Yamazaki Masahide , Morishita Eriko , Miyamoto Ken-ichi , Nakao Shinji , Asakura Hidesaku 
Published: March 2018

SummaryWe have investigated the role of two vasoactive substances, nitric oxide (NO) and endothelin (ET), in the pathophysiology of disseminated intravascular coagulation (DIC), using two types of DIC models. Experimental DIC was induced by sustained infusion of 0.1, 1, 10, or 50 mg/kg lipopolysaccharide (LPS), or 3.75 U/kg thromboplastin (TF), for 4 h via the rat tail vein. Plasma levels of both NOX (metabolites of NO) and ET were significantly increased following infusion of 0.1 mg/kg or greater of LPS in the LPS-induced DIC rat model. In contrast, although a marked increase in the plasma levels of NOX was observed, only a slight increase in plasma ET levels was seen in the TF-induced DIC rat model. No significant differences in the plasma levels of platelets or thrombin-ATIII complex were observed among the TF-induced and LPS (50 mg/dl)-induced DIC models. However, plasma NOX levels rose significantly higher in the TF-induced model, relative to the LPS-induced model (p <0.01). Conversely, plasma ET levels were significantly greater after LPS-induction, compared to TF-induction, of DIC (p <0.01). Vasoconstriction, as well as depressed fibrinolytic activity, may be additional factors leading to severe organ dysfunction in the LPS-induced DIC rat model. Moreover, vasodilatation, as well as enhanced fibrinolytic activity, may help to prevent rats from severe organ dysfunction in the TF-induced DIC model. Our results suggest that modulator of vasoactive substances should be examined in the treatment of DIC.
Antithrombotic Effects of DX-9065a, a Direct Factor Xa Inhibitor
Authors: Shimbo Daichi , Osende Julio , Chen Julie , Robbins Jonathan , Shimoto Yoshimasa , Kunitada Satoshi , Fuster Valentin , Badimon Juan 
Published: March 2018

SummaryRecent evidence suggests that TF may play a causal role in acute coronary syndromes, and may be an important therapeutic target. Several inhibitors of TF, coagulation factors VIIa and Xa are under investigation as novel antithrombotic approaches. We compared the antithrombotic effects of DX-9065a, a new FXa inhibitor, vs. enoxaparin.The protocol was an open-label crossover study. Subjects (n = 6) participated in 3 consecutive study-arms: a) enoxaparin + ASA (1 mg/Kg s. c + 162 mg/day X 3 days), b) three escalating doses of DX-9065a (1 mg bolus + 0.25 mg/h X 2 h, followed by an additional 1 mg bolus + 0.625 mg/h X 2 h and, a final 1 mg bolus + 1.25 mg/h X 2 h), and c) the same doses of DX-9065a in Arm 2 plus ASA pre-treatment. The antithrombotic effects were assessed using the Badimon perfusion chamber at each dose level.The administration of DX-9065a whether alone or combined with ASA significantly inhibited thrombus formation at high and low shear rate conditions while enoxaparin did not have a significant effect. Furthermore, these antithrombotic effects were obtained without significant prolongations of the standard coagulation parameters as those induced by enoxaparin.The direct inhibition of FXa by DX-9065a appears to be a safe and effective new approach for preventing the thrombotic complications of atherosclerotic disease. The clinical effectiveness of the direct FXa inhibitors should be further investigated.