bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of the DSM-5-based criteria for Internet addiction: A factor analytical examination of three samples
Authors: Besser Bettina , Loerbroks Lotta , Bischof Gallus , Bischof Anja , Rumpf Hans-Jürgen 
Published: May 2019

Background and aims
The diagnosis “Internet Gaming Disorder” (IGD) has been included in the fifth edition of Diagnostic and Statistical Manual of Mental Disorders. However, the nine criteria have not been sufficiently reviewed for their diagnostic value. This study focuses on a broader approach of Internet addiction (IA) including other Internet activities. It is not yet clear what the construct of IA is in terms of dimensionality and homogeneity and how the individual criteria contribute to explained variance.

Methods
Three separate exploratory factor analyses and multinomial logistic regression analyses were carried out based on information collected from a general population-based sample (n = 196), a sample of people recruited at job centers (n = 138), and a student sample (n = 188).

Results
Both of the adult samples show a distinct single-factor solution. The analysis of the student sample suggests a two-factor solution. Only one item (criterion 8: escape from a negative mood) can be assigned to the second factor. Altogether, high endorsement rates of the eighth criterion in all three samples indicate low discriminatory power.

Discussion and conclusions
Overall, the analysis shows that the construct of IA is represented one dimensionally by the diagnostic criteria of the IGD. However, the student sample indicates evidence of age-specific performance of the criteria. The criterion “Escape from a negative mood” might be insufficient in discriminating between problematic and non-problematic Internet use. The findings deserve further examination, in particular with respect to the performance of the criteria in different age groups as well as in non-preselected samples.
ASSOCIATION OF HLA HAPLOTYPES WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN CONDITIONS OF ORGANIC- SILICON MANUFACTURE
Authors: Karzakova L. M. , Muchukova O. M. , Borisova L. V. , Kudryashov S. I. 
Published: May 2019

One of the urgent problems of modern medicine is the search for genetic markers of chronic obstructive pulmonary disease (COPD).The aim of the study was to investigate the relationship between HLA haplotypes and COPD in individuals whose illness developed during the professional work in the workshop of organic-silicon production of PJSC "Khimprom" (Novocheboksarsk, Russia).The study included patients with COPD in remission, belonging to the Chuvash ethnic group of Russia - 36 women and 26 men (mean age 45.4±2.3 years). The work experience averaged 15.2±2.4 years, the duration of COPD - 12.3±2.4 years. Smokers made up 22.0±5.8% of the total number of patients. The comparison group was a group of non-patients with COPD workers of organic-silicon manufacture. This group was positioned as "stable" to the development of COPD. Class I HLA antigens were typed in the standard microlymphocytotoxic test using histotyping anti-HLA sera to 8 HLA-A antigens of the locus A1, A2, A3, A9, A10, A11, A19, A28 and to 18 HLA-B antigens of the locus В5, В7, В8, В12, В13, В14, В15, В16, В17, В18, В21, В22, В27, В35, В40, В41, В42, В53) (CJSC “Interregional Center of Immunogenetics and Histotyping Reagents “Gisans”, St. Petersburg). HLA genotyping of class II alleles was carried out by the multi-primer polymerase chain reaction method in DNA, obtained from nuclear cells of peripheral blood, using reagent sets of the firm “DNA-Technology” (Moscow), according to the reagent manufacturer's method. They were typified by 14 alleles of the DRB1 locus, 8 to the DQA1 alleles and 11 to the DQB1 alleles. The frequencies of two-locus haplotypes were calculated using the computer program "Arlequin v. 3.01 ". The association strength of HLA with COPD was determined by the relative risk (RR) of the formula J. Haldane. The statistical reliability of the difference between RR and 1 was determined by the exact two-sided Fisher test. As a result of the study, the positive association of COPD with haplotypes was established: HLA-A9-DQA1*0501, A10-DQA1*0103, A28-DQA1*0102, B7-DQA1* 0103. These haplotypes can be attributed to genetic markers of predisposition to the development of COPD. The negative association with the disease was established for haplotypic combinations of the alleles HLA-A2-B8, A19-DQB1*0502-04, B12-DQB1*0502-04, B27-DQA1*0103, DRB1*01-DQA1*0101, DRB1*07-DQA1*0201, DRB1*13-DQA1 * 0102. This series of haplotypes can be attributed to the category of protective genetic markers of COPD in conditions of organic-silicon manufacture. In continuation of our studies, further research is needed to identify "marker" HLA haplotypes in COPD in other ethnic populations, as well as under the influence of other aggressive air pollutants. The results of the study indicate the association of COPD with a number of specific HLA-haplotypes.
FAMILIAL MEDITERRANEAN FEVER AMONG KURDISH CHILDREN; A SINGLE CENTER STUDY
Authors: Khurshid Bakhtyar , Rashid Jamal , Salih Khalid , Muhamad Dlnya 
Published: May 2019

Background
Familial Mediterranean Fever is recessively inherited auto inflammatory disease. It shows an obvious ethnic distribution, which is mainly prevalence among Eastern Mediterranean people.
Objectives
The aim of the present study is an accurate diagnosis of FMF in Kurdish children by detection of genetic mutations in addition to clinical features.
Patients and Methods
In the current study, clinical data for 20 patients, aged 18 years or younger, affected by FMF was analyzed and discussed. Those diagnosed as FMF, according to Tel-Hashomer criteria and sent for genetic confirmation were included in the study. The cases were collected from different hospital and Pediatric clinics in Sulaimani, Kurdistan Region, Iraq between December 2017 to May 2018.
Results
Among 20 patients who were diagnosed with FMF, (60%, n=12) of them were male and (40%, n=8) were female, leading to a male to female ratio of 1.5:1. The mean age of onset of symptoms was 3 ± 2.6 years, and the mean delay in diagnosis was 3.17 ± 2.02 years. The main clinical features were as follows: fever which counted for (95%), followed by abdominal pain (75%), joint pain (45%), and skin rash (15%). Family history of FMF was presented in 10% of the cases. Regarding Genetic analysis, the most common type of mutation was found to be M694V (36.8%), followed by M680I (23.7%), M694I (18.4%), V726A (15.8%), E148Q (2.6%) and A744S (2.6%). Only 5% of the cases had undergone an appendectomy before diagnosis. Regarding using of colchicine, it has been noticed that 5.3% of the cases were non-responder. None of the patients was found to have renal amyloidosis.
Conclusion
Clinical criteria with genetic study are the most preferred methods in diagnosis of FMF cases. Genotype results were found to be similar to the FMF patients of ethnic Arabs and, to a degree, to those of Turkish patients.
STAGE DISTRIBUTION AND PATIENT RESPONSE POST NEO-ADJUVANT SHORT COURSE RADIOTHERAPY IN RECTAL CANCER, SINGLE CENTER STUDY
Authors: Mohammed Kamaran , Ghalib Hawar 
Published: May 2019

Background
Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide, accounting for approximately 1,400,000 new cases and about 700,000 deaths worldwide.
Objectives
The objective of this study is to assess patients’ response and developments of complication, after the use of neo-adjuvant short course radiotherapy in addition to the effect of this treatment modality on pathological response, local control and distant metastasis.
Methods
Forty six patients, who were histopathologically proven to have colorectal carcinoma, were randomly assigned to receive 25 Gy of radiation, in a short period of time prior to surgical resection of tumor. Local control, distance metastasis and post operative signs and symptoms measured over a period of 5 years (2013-2018). The treatment period ranged between 3-327 days.
Results
The overall survival of patients and their experience with post operative toxicity was improved; there was statistically significant correlation between spread of the tumor and duration of radiotherapy, p value was less than 0.05.In addition 84% of cases had no recurrence. Overall survival was about 76% of cases at the end of this research. The rate of post operative complication decreased. But the duration of radiotherapy had no significant effect on the mortality. (p value=0.2)
Conclusion
Preoperative short-course radiotherapy before colorectal surgical intervention favors better local control and distant metastasis in addition to less complication, more comfort for patients and favorable survival rate.
Cost comparisons of five leading brands of the antihypertensive drug, Telmisartan, available in an Indian city
Authors: Rajadnya Vikram A. , Bedi Sheena R. 
Published: May 2019

Background: Antihypertensive drugs have to be taken lifelong, after initiation of the treatment. Price variation can lead to huge economic burden on the patients of hypertension, especially when cost considerations are not undertaken by the prescribing physician . This study was undertaken to compare the annual cost , to the patient , of five different most commonly prescribed brands of Telmisartan 40 mg, in Kolhapur city.Methods: Authors purchased a strip of 10 tablets each of the five leading brands in one city, Kolhapur, India, of Telmisartan 40 milligram. The prices of the strip of 10 tablets of each of the five selected brands were compared. In turn the annual cost of each of these five, was compared directly as well as using percentages. The data was collected, analysed and presented.Results: The data of the cost of the preparations of five different brands of a single antihypertensive drug, Temisartan 40 milligram shows that the annual cost of the costliest among the three brands of this drug is almost three times , that of the cheapest brand, or in other words almost 300 percent that of the cheapest brand.Conclusions: the cost variation amongst the five brands was considerable. India being a country with a major chunk of the population being very price sensitive, the prescribing physician must select the brand carefully. The most costly preparation of Temisartan can significantly add to the burden on the patient’s annual budget. Thus, Pharmacoeconomics must take an important place while prescribing medicines, especially in a country like India.
ПРОГНОЗНО-ПОИСКОВАЯ МОДЕЛЬ ЭПИТЕРМАЛЬНЫХ Au-Ag МЕСТОРОЖДЕНИЙ КИСЛОТНО7СУЛЬФАТНОГО ТИПА ПО ДАННЫМ ДЕШИФРИРОВАНИЯ СОВРЕМЕННЫХ КОСМИЧЕСКИХ СНИМКОВ (НА ПРИМЕРЕ РУДНОГО ПОЛЯ СВЕТЛОЕ, ХАБАРОВСКИЙ КРАЙ)
Authors: Ананьев Юрий Сергеевич , Житков Владимир Георгиевич , Поцелуев Анатолий Алексеевич 
Published: May 2019

Актуальность. Расширение минерально-сырьевой базы действующих горнодобывающих предприятий требует современных подходов в изучении сопредельных площадей. Одним из таких современных методов в изучении площадей является использование современных спектрозональных космических снимков в целях выделения потенциально рудоносных площадей на основе структурно-вещественного дешифрирования. Основная цель исследования заключалась в разработке критериев эпитермального золото-серебряного оруденения в пределах Охотско-Чукотского вулканического пояса на основе материалов дистанционных съемок. Объектами исследования послужили известные рудные таксоны юго-восточного фланга Ульинской минерагенической зоны Охотско-Чукотского вулканического пояса. Методы: обработка, спектральный анализ и дешифрирование современных спектрозональных космических снимков Landsat, Aster и снимков высокого пространственного разрешения Ikonos, WorldView, QuickBird. Результаты. Разработаны региональные, локальные и детальные критерии Au-Ag оруденения на примере одного из участков Ульинской минерагенической зоны. Структурными критериями регионального уровня являются участки пересечения разнонаправленных разрывных нарушений во вложенных соподчиненных кольцевых структурах диаметром от 20 до 90 км. Структурно-вещественные критерии локального уровня – области сопряжения систем вложенных соподчиненных кольцевых структур размером от 1 до 10 км с зонами развития Fe-окисных индексов. К структурно-вещественным критериям детального уровня отнесены малые кольцевые структуры, выполненные телами вторичных кварцитов различных минеральных ассоциаций, сопряженные с зонами развития Fe-окисных индексов, внутри участков пропилитового типа изменений. На основе выявленных особенностей строения рудного поля Светлое, дан прогноз о перспективности южного и юго-восточного фланга на выявление золото-серебряного эпитермального оруденения. Предложена иерархическая дистанционная прогнозно-поисковая модель эпитермальных Au-Ag месторождений.
ВЛИЯНИЕ АЦЕТАТ- И ЦИТРАТ-ИОНОВ НА ПРОТЕКАНИЕ ПРОЦЕССА КАТОДНОГО ВОССТАНОВЛЕНИЯ Yb(III) НА РТУТНЫХ ЭЛЕКТРОДАХ
Authors: Коршунов Андрей Владимирович , Ковалева Светлана Владимировна , Абрамова Полина Владимировна , Горлушко Дмитрий Александрович 
Published: May 2019

Актуальность. Иттербий, его сплавы и соединения характеризуются особыми термоэлектрическими, магнитными и оптическими свойствами; иттербийсодержащие материалы находят применение в военной и атомной промышленности. Вследствие высокой химической активности, а также сходства с другими редкоземельными элементами технологии выделения иттербия включают большое количество операций, в их числе осаждение, электролиз, цементация, адсорбция и др. Особенностью иттербия (а также европия и самария) по сравнению с другими редкоземельными элементами является возможность катодного осаждения на ртутном электроде и образования амальгамы при сравнительно невысоких отрицательных потенциалах. В связи с этим исследование закономерностей протекания электродных процессов с участием иттербия является актуальной задачей как с фундаментальной, так и с технологической точки зрения. Цель: определить особенности влияния комплексообразователей (ацетат- и цитрат-ионов) на протекание процесса катодного восстановления Yb(III) на ртутных электродах. Объекты: оксид иттербия, хлорная и уксусная кислоты, растворы солей (NaClO4, LiCl, N(C2H5)4Cl, ацетата и цитрата натрия) и щелочей (NaOH). Методы: полярография постоянного и переменного тока, циклическая вольтамперометрия. Результаты. Уточнена область потенциалов протекания катодного процесса Yb(III)®Yb(II) (1×10–4…1×10–3 М) на ртутных электродах (капающем, стационарном) в некомплексообразующих и комплексообразующих (ацетатном, цитратном) фоновых электролитах в широком интервале рН=2…9. Установлено влияние комплексообразования Yb(III) на соотношение токов восстановления ионов иттербия и водорода и на устойчивость промежуточного продукта Yb(II) катодного процесса в среде раствора. Показан каталитический характер химической реакции окисления Yb(II) ионами водорода в прикатодном слое раствора на протекание процесса Yb(III)®Yb(II) в области потенциалов –1,3…–1,5 В (нас. х.с.э.). Интерпретация результатов электрохимических исследований проведена с использованием расчётных диаграмм Е-рН для систем Yb–H2O–CH3COO– и Yb–H2O–Cit3– в сравнении с системой без комплексообразователя. Показана важность учёта состояния Yb(III) в растворе и условий электролиза при протекании катодного процесса.
The Relationship Between Patients' Safety-Related Behaviors and Safety Events and Patient Experiences in Korean Hospitals
Authors: Hwang Jee-In , Kim Sung Wan , Chin Ho Jun 
Published: May 2019

Background and PurposeThere is increasing interest in patient participation in healthcare aimed at enhancing safety. The purposes of this study were to examine levels of patients' safety-related behaviors and to determine their relationships with safety events and care experiences.MethodsA cross-sectional survey was conducted with 360 patients in two tertiary general hospitals in Korea. The final dataset consisted of 341 patient responses. A questionnaire was developed to collect information concerning patients' safety-related behaviors, care experiences, and the occurrence of safety events. Univariate and multivariate analyses were performed.ResultsOn average, patients participated in 10.0 (SD 5.4) safety-related behaviors. Sixty-five (19.1%) patients reported experiencing at least one adverse event related to medical management. The mean problem score for care experience was 39.4 (SD 27.8) out of 100.0. Multiple logistic analysis showed that patients with adequate health literacy and higher activation levels were more likely to have high safety-related behavior participation levels. High participation in safety-related behaviors was negatively associated with the occurrence of safety events. However, no significant relationship was found between patient participation and the total problem scores for care experience.Implications for PracticeThese findings suggest that efforts to support patients with limited health literacy and low activation levels are needed to facilitate patient participation. Active participation in safety-related behaviors can contribute to improving patient safety.
Pulmonary nodules volumetry. Variability in Results After Manual Correction of Contours
Authors: Rozengauz E. V. , Nesterov D. V. , Al’derov Z. A. , Korablin N. M. 
Published: May 2019

Objective. To study variability of volumetric of the pulmonary nodules volumetry after manual correction of their contours.Material and methods. Twenty-seven nodules uncircumscribed from the vascular structures and pleura were selected. A linear regression model was used to investigate the impact of the size of a nodule, the area of its contact with the adjacent structures on variability in results.Results. The linear regression model based on contact area and nodule size can correctly predict volumetry variability.Conclusion. Even after manual segmentation volumetry remain suitable method for size assessment of lung nodules. Segmentation should be made with the same person because of significant difference of interobserver and intraobserver variabilities.
Looking for Fracturing Sand That is Cheap and Local
Authors: Rassenfoss Stephen 
Published: May 2019

Proppant buyers insist on the “lowest cost for an appropriate sand.” That assessment was offered by Hayden Gillespie, president and chief operating officer of Black Mountain Sand, one of the mining companies that has driven down sand prices by building sand mines within a couple of hours’ drive from where it is used.
Cheap sand is easy to find in the Permian Basin, where regional sand mines have glutted the market. Nearby suppliers have an unbeatable price advantage over distant mines, which not long ago produced most of the sand used for propping fractures.
Appropriate is harder to define. The rules are changing as customers try new mixes of sand size and find that production data does not support many of the old standards.
In the Eagle Ford, oil companies are using sand size ranges that stretch the traditional API size specifications beyond recognition (Fig. 1). Rather than using old standards such as 40/70 mesh—the biggest grains must fit through a screen of 40 wires per inch, and the smallest cannot go through a screen of 70 wires per inch—they are using 40/140, where minimal sifting is required. Fracturing sand buyers still have needs, but they vary.
“I believe until all the companies are merged into one there will be different ideas” about how to get the most out of the local geology, said Mike Fleet, executive vice president for mining operations for Vista Proppant and Logistics.
The challenge for proppant suppliers is matching customer desires with the sand they mine.
“Vista has a hand-in-hand relationship with our customers,” Fleet said. The goal is to give them what they need, but “we can only do what mother nature puts in the ground,” he said.
Vista’s biggest mine, which is near Fort Worth, Texas, delivers grains ranging from mid-sized (40/70) to unusually small grains that it calls 200 mesh, via its logistics network to customers in Texas and Oklahoma. Vista also has in-basin mines in the Permian Basin, it is building its first mine in Oklahoma, and it is looking for a location for a mine in the Eagle Ford, said Chris Favors, vice president for business relations at Vista.
In the South Texas play, the competition includes mines selling low-cost options. such as 40/140. This product contains most of the finer grain sand dug up from local pits, with processing to remove clay and fine dirt.
The approach is more like the original river sand mined for the first fractures rather than products sold with grains within the strict size limits set by API standards. Gillespie describes his sand as a “coarse 100 mesh.” It mixes some larger grains with 100-mesh sand.
ConocoPhillips has long experience in the Eagle Ford and has done extensive testing there to evaluate completions, including one of the only research projects that collected core samples of fractured rock around a well (URTeC 2670034). Based on its well performance analysis, it is open to offers on new proppant specifications.
Technology Focus: Intelligent Operations (May 2019)
Authors: Hudson John 
Published: May 2019

Technology Focus
When I was a chemical engineering student, my cohort joked about the relative merits of McCabe-Thiele and Ponchon-Savarit (graphical distillation design methods) and which of these they liked better. Perhaps as a petroleum engineering student, you did the same with Horner and Blasingame. While still useful for understanding the basic physics behind design, by the 1990s, actual equipment design and performance assessments already were being performed typically by increasingly sophisticated computer programs. These programs would eventually invert problems such as these, from one in which the performance of a design is demonstrated to one in which an optimization problem is specified and then iterated to find the best design. The movement away from graphical design methods to physics-based modeling was an inflection point with profound effects—for example, pilot plants mostly disappeared while confidence in engineering outcomes dramatically improved.
We are approaching a similarly profound inflection point. Many of the advances that will drive this transition have already happened, such as bandwidth and computing costs dropping to almost nothing with access becoming nearly universal, sensors becoming plentiful and the information they provide increasingly rich, and business models changing from a buy/own/use approach to an everything-as-a-service model. Business opportunities now no longer wait for needed technology, but they may be limited by the rate at which we adapt our processes and culture.
In recent years, we have seen that the papers highlighted in this section have detailed corporate aspirations, science projects that pointed to the potential of coming technologies, and early proofs of concepts and case studies highlighting learnings. As you read the examples in this section, you will see that a change is already under way in that the methods that are being used are increasingly not oil-and-gas-specific but instead follow patterns that are being used in other industries that are perhaps a bit further into the transformation.
It is my hope that these examples will challenge and inspire. If you are an academic, will your students be ready to practice the transformed work flows that are coming? If you are a provider, are you anticipating how your services will evolve and take advantage of other emerging services? For the operator, are you evolving your capabilities, developing your staff, and working closely with the right partners to position your future success?
Recommended additional reading at OnePetro: www.onepetro.org .
SPE 192627 Digitalization of a Giant Field—The Rumaila Story by Yaser Salman, Rumaila Operating Organisation, et al.
SPE 190827 Field-Scale Production Optimization With Intelligent Wells by Osho Ilamah, Nexen, et al.
SPE 189808 Data-Based Smart Model for Real-Time Liquid-Loading Diagnostics in Marcellus Shale Through Machine Learning by Amir Ansari, West Virginia University, et al.