bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy success and outcomes after uterine fibroid embolization: updated review of published literature
Authors: Ludwig Parker E , Huff Trevor J , Shanahan Meaghan M , Stavas Joseph M 
Published: October 2019

Females with symptomatic leiomyomas (fibroids) wishing to maintain fertility are faced with difficult treatment choices. These include uterine fibroid embolization (UFE), myomectomy, hormonal therapy, MRI high intensity focused ultrasound, and myolysis. This review focuses on UFE, one of the most commonly accepted minimally invasive procedural choices among patients with symptomatic fibroids wishing to retain the option of becoming pregnant in the future, and makes comparisons to myomectomy which has historically been the surgical choice for fertility-preserving fibroid treatment. Pubmed and Google Scholar searches using keywords such as: uterine artery embolization, uterine fibroid embolization, pregnancy, complications, infertility were performed between Jan 1, 2019 and May 10, 2019. Publications were chosen based on their inclusion of information pertaining to fertility or pregnancy after UFE without being limited to single case reports.
Randomized controlled trials comparing myomectomy and UFE are limited due to study size and confounding variables, but through registry data and familiarity with referring clinicians, UFE has gained wide acceptance. Healthy pregnancies following UFE have been sporadically reported but the actual fertility rate after UFE remains uncertain. Conversely, low birth weight, miscarriage and prematurity have been associated with UFE. Despite inherent risks of possible fertility issues after UFE, the procedure remains an option for females with clinically symptomatic fibroids who desire pregnancy. However, additional research regarding rates of conception and obstetrical risks of infertility following UFE is necessary.
In silico analysis of a major allergen from Rattus norvegicus, Rat n 1, and cross-reactivity with domestic pets
Authors: Munera Marlon , Contreras Neyder , Sánchez Andres , Sánchez Jorge , Emiliani Yuliana 
Published: October 2019

Background: Lipocalins play a role in the cellular trafficking of pheromones and are involved in allergic responses to domestic pets. However, the cross-reactivity among allergens of this group has been poorly explored, and the pheromone linking capacity is not well characterized. The aim of this study was to explore cross-reactive epitopes and pheromone linking capacity among Rat n 1 and homologues in domestic pets through an in silico approach. Methods: ElliPro and BepiPred in silico tools were used to predict B cell linear and cross-reactive epitopes. The pheromone linking capacity was explored by docking virtual screening with 2-ethylhexanol, 2,5-dimethylpyrazine, 2-sec-butyl-4,5-dihydrothiazole, and 2-heptanone ligands. Results: According to the analysis, Rat n 1 shares 52% identity with Equ c 1, Can f 6, Fel d 4, and Mus m 1 allergens. The overlapping structures assay revealed high structural homology (root mean square deviation < 1). Four lineal and three discontinuous epitopes were predicted on Ra t n 1. A lineal epitope located between amino acids residues 24 and 36 was highly conserved on all allergens explored. A cross-reactive discontinuous epitope (T142, K143, D144, L145, S146, S147, D148, K152, L170, T171, T173, D174) was also found. Docking molecular simulations revealed the active site, and we identified the properties of the binding of four pheromones and the binding potential of Rat n 1. Critical residues for interactions are reported in this study. Conclusions: We identified some possible allergens from Rattus norvegicus, and those allergens could have cross-reactivity with allergens from some animals. The results need to be confirmed with in vitro studies and could be utilized to contribute to immunotherapy and reduce allergic diseases related to lipocalins.
5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes
Authors: Yang Ying , Zeng Chang , Lu Xingyu , Song Yanqun , Nie Ji , Ran Ruoxi , Zhang Zhou , He Chuan , Zhang Wei , Liu Song-Mei 
Published: October 2019

AbstractBACKGROUNDLong-term complications of type 2 diabetes (T2D), such as macrovascular and microvascular events, are the major causes for T2D-related disability and mortality. A clinically convenient, noninvasive approach for monitoring the development of these complications would improve the overall life quality of patients with T2D and help reduce healthcare burden through preventive interventions.METHODSA selective chemical labeling strategy for 5-hydroxymethylcytosines (5hmC-Seal) was used to profile genome-wide 5hmCs, an emerging class of epigenetic markers implicated in complex diseases including diabetes, in circulating cell-free DNA (cfDNA) from a collection of Chinese patients (n = 62). Differentially modified 5hmC markers between patients with T2D with and without macrovascular/microvascular complications were analyzed under a case–control design.RESULTSStatistically significant changes in 5hmC markers were associated with T2D-related macrovascular/microvascular complications, involving genes and pathways relevant to vascular biology and diabetes, including insulin resistance and inflammation. A 16-gene 5hmC marker panel accurately distinguished patients with vascular complications from those without [testing set: area under the curve (AUC) = 0.85; 95% CI, 0.73–0.96], outperforming conventional clinical variables such as urinary albumin. In addition, a separate 13-gene 5hmC marker panel could distinguish patients with single complications from those with multiple complications (testing set: AUC = 0.84; 95% CI, 0.68–0.99), showing superiority over conventional clinical variables.CONCLUSIONSThe 5hmC markers in cfDNA reflected the epigenetic changes in patients with T2D who developed macrovascular/microvascular complications. The 5hmC-Seal assay has the potential to be a clinically convenient, noninvasive approach that can be applied in the clinic to monitor the presence and severity of diabetic vascular complications.
Lactobacillus plantarum B7 attenuates Salmonella typhimurium infection in mice: preclinical study in vitro and in vivo
Authors: Wongsen Siwaporn , Werawatganon Duangporn , Tumwasorn Somying 
Published: October 2019

Abstract

Background

Salmonella typhimurium is a cause of gastroenteritis including diarrhea. Lactobacillus plantarum is a probiotic widely used to prevent and treat diarrhea.

Objectives
To determine the protective effects of L. plantarum B7 on diarrhea in mice induced by S. typhimurium.

Methods
Inhibition of S. typhimurium growth by L. plantarum B7 was determined using an agar spot method. Mice were divided into 3 groups (n = 8 each): a control group, an S group administered 3 × 109 CFU/mL S. typhimurium, and an S + LP group administered 1 × 109 CFU/mL L. plantarum B7 and 3 × 109 CFU/mL S. typhimurium daily for 3 days. Counts of S. typhimurium and percentage of fecal moisture content (%FMC) were determined from stool samples. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and CXCL1 were determined.

Results

L. plantarum B7 produced a clear zone on S. typhimurium. There were significantly less S. typhimurium in the feces from mice in the S+LP group than in the S group. Serum levels of TNF-α, IL-6, and CXCL1 in mice from the S group were significantly higher than levels in the S+LP and control groups. Feces from mice in the S group were soft and loose, whereas in the S+LP group they were hard and rod shaped. The %FMC in the S+LP group was significantly less than in the S group.

Conclusions

L. plantarum B7 can inhibit growth of S. typhimurium, decrease levels of proinflammatory cytokines, and attenuate symptoms of diarrhea induced in mice by S. typhimurium.
Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats
Authors: Likitnukul Sutharinee , Kalandakanond-Thongsong Sarinee , Thammacharoen Sumpun 
Published: October 2019

Abstract

Background
Plasma leptin is regulated by several factors, including growth hormone (GH), which influences the pathophysiology of obesity.

Objective
To demonstrate the short-term effect of GH on plasma leptin levels in 3 conditions in vivo with the different amount of body fat mass.

Methods
Adult male Wistar rats were fed with standard chow or hypercaloric diet (HC). The HC rats were demonstrated as HC-feeding obese (HC-O) and HC-feeding resistant (HC-R) rats. Then, they were treated with GH or saline for 3 days. Basal plasma leptin levels were measured at 24 and 32 h. For meal-induced condition, all rats were fed for 2 hand plasma leptin was measured. Further 16-h fasting period, plasma leptin, insulin, and insulin sensitivity indexes were determined.

Results
The short-term GH treatment decreased basal plasma leptin at 32 h after the first GH injection in HC-O rats. However, GH treatment had no effect on meal-induced plasma leptin in all rats. Furthermore, GH treatment attenuated fasting effect on plasma leptin in control and HC-R rats. The insulin resistance (IR) induced by the short-term GH treatment was demonstrated by higher fasting plasma insulin and the increased homeostasis model of IR in HC-R rats.

Conclusions
The study demonstrates the important role of greater fat mass in HC-O rats, which results in decreased basal plasma leptin after short-term GH treatment. For meal-induced condition, GH had no effect on plasma leptin in all rats. Interestingly, GH could attenuate fasting effect on plasma leptin in rats that have lower fat mass.
Generalized implicit viscosity approximation method for multivalued mappings in CAT(0) spaces
Authors: Abbas Mujahid , Iqbal Hira , de la Sen Manuel 
Published: October 2019

Abstract
We prove strong convergence of the sequence generated by implicit viscosity approximation method involving a multivalued nonexpansive mapping in framework of CAT(0) space. Under certain appropriate conditions on parameters, we show that such a sequence converges strongly to a fixed point of the mapping which solves a variational inequality. We also present some convergence results for the implicit viscosity approximation method in complete ℝ-trees without the endpoint condition.
Evaluation of Electrocoagulation and Activated Carbon Adsorption Techniques Used Separately or Coupled to Treat Wastewater from Industrial Dairy
Authors: Eulmi Amina , Hazourli Sabir , Abrane Rahma , Bendaia Marwa , Aitbara Adel , Touahria Soraya , Chérifi Mouna 
Published: October 2019

AbstractThis present study focuses on the evaluation of the effectiveness and the feasibility of a combined treatment between the electrocoagulation (EC) and the adsorption on an activated carbon in grains (GAC) in a continuous mode. The peculiarity of this work is that the experiments are conducted with real wastewater from an industrial dairy. This combined treatment first required an optimization of the EC followed by an adsorption. For each of these techniques, different influential operating parameters such as the current density, the reaction time, the GAC dose, the initial turbidity of water … etc., have been studied. The Turbidity and the COD have been continuously analyzed, while the phosphorus, the BOD5, TSS, nitrogen and the grease have been punctually analyzed, and this happened before and after the water treatment. The EC adsorption coupling results have shown that the addition of an appropriate dose of GAC (2 gL−1) in a separate column, increases the effectiveness of treatment; more than 98 % of reduction for the COD, the BOD5, the turbidity and the greases. A mechanism explaining the phenomena which are involved in this combined treatment is proposed. On the basis of these results of efficiency, speed, low operational cost (~ 3 $m−3of the treated water), and in comparison with the EC used alone, the EC coupling/the adsorption GAC, could be recommended as a treatment of separation for waters at a high load in organic pollutants.
Optimal Power Flow Management and Control of Grid Connected Photovoltaic-Battery System
Authors: Bhende Chandrashekhar N , Panda Swasti , Mishra Sukumar , Narayanan Arun , Kaipia Tero , Partanen Jarmo 
Published: October 2019

Abstract
This paper presents optimal power flow management in real time for grid connected photovoltaic (PV)–battery system. The objective is the real time, dynamic and optimal scheduling of battery storage which reduces grid power consumption and achieves the peak load shaving. For this purpose, two strategies are developed; one is rule-based and other is optimization algorithm based. Two strategies are compared, pros and cons of those strategies are established. Though rule-based technique is simple & easy to implement, the optimization technique provides more optimal regulation of battery which provides the lesser electricity cost. Forecasted PV/load powers are used to get optimal value of battery power. In order to handle uncertainties due to forecasted data, fuzzy-based corrective strategy is developed to modify the reference battery power as per the present values of PV/load powers. The proposed analysis is carried out for over one exemplary day. The simulations are presented using typical load/PV data of India and Finland as a part of research collaboration. Experimental results are also carried out using proposed scheme.
Language and creativity: a Construction Grammar approach to linguistic creativity
Authors: Hoffmann Thomas 
Published: October 2019

Abstract
Creativity is an important evolutionary adaptation that allows humans to think original thoughts, to find solutions to problems that have never been encountered before and to fundamentally change the way we live. One particular domain of human cognition that has received considerable attention is linguistic creativity. The present paper discusses how the leading cognitive linguistic theory, Construction Grammar, can provide an explanatory account of creativity that goes beyond the issue of linguistic productivity. At the same time, it also outlines how Construction Grammar can benefit from insights from Conceptual Blending.
Thermodynamic parameters for the complexation of Tc(IV) with bromide under aqueous conditions
Authors: Eiroa-Lledo Cecilia , Wall Donald E. , Wall Nathalie A. 
Published: October 2019

Abstract
Technetium-99 is a long-lived fission product present in nuclear wastes, found mainly as Tc(VII) and Tc(IV) in the environment. The quantification of the equilibrium constants for the formation of Tc(IV) aqueous complexes has been limited to carboxylate ligands and interactions with the halides is mostly unknown. This work reports equilibrium constants of the formation of the TcO(OH)+ complexes with Br−, in a 3 M NaClO4 solution of pcH 2 and varied temperature, using a liquid-liquid extraction system. Neutron activation confirmed the suitability of the extraction technique for this work. Under the working conditions, Br− forms a weak exothermic TcO(OH)Br complex, with a Gibbs free energy (ΔGr) of 3 ± 3 kJ · mol−1 at a temperature of 273.15 K. The values for ΔHr (−32 ± 3 kJ · mol−1) and ΔSr (106 ± 9 J · mol−1 · K−1) of the complexation reaction were quantified using a van’t Hoff analysis. This work also showed that bromide addition does not displace the hydroxide from TcO(OH)+, as the equilibrium constant of bromide addition is much weaker than the first hydrolysis constant of the metal.
Investigation of porosity effect on flexural analysis of doubly curved FGM conoids
Authors: Ansari Md Irfan , Kumar Ajay , Barnat-Hunek Danuta , Suchorab Zbigniew , Kwiatkowski Bartłomiej 
Published: October 2019

Abstract
The flexural analysis of doubly curved functionally graded porous conoids was performed in the present paper. The porosities inside functionally graded materials (FGMs) can occur during the fabrication and lead to the occurrence of micro-voids in the materials. The mathematical model includes expansion of Taylor’s series up to the third degree in thickness coordinate and normal curvatures in in-plane displacement fields. Since there is a parabolic variation in transverse shear strain deformation across the thickness coordinate, the shear correction factor is not necessary. The condition of zero-transverse shear strain at upper and lower surface of conoidal shell is implemented in the present model. The improvement in the 2D mathematical model enables to solve problems of moderately thick FGM porous conoids. The distinguishing feature of the present shell from the other shells is that maximum transverse deflection does not occur at its centre. The improved mathematical model was implemented in finite element code written in FORTRAN. The obtained numerical results were compared with the results available in the literature. Once validated, the current model was employed to study the effect of porosity, boundary condition, volume fraction index, loading pattern and others geometric parameters.
Absence of material exponence
Authors: Stolz Thomas , Levkovych Nataliya 
Published: October 2019

AbstractThe paper argues in favor of considering the absence of material exponence (AOME) of grammatical category a morphological mismatch on a par with established categories such as suppletion and syncretism. It is shown that the phenomenon under review can be integrated into the taxonomy of deviations from canonical inflection as proposed within the framework of Canonical Morphology. Empirical evidence from eleven languages of different genetic, geographic and typological background is presented and discussed. Different kinds of AOME are identified. Their interaction with other non-canonical phenomena is discussed additionally.
A Comparison of the Responsiveness of the Postural Assessment Scale for Stroke and the Berg Balance Scale in Patients With Severe Balance Deficits After Stroke
Authors: Huang Yi-Jing , Lin Gong-Hong , Lee Shih-Chieh , Hsieh Ching-Lin 
Published: October 2019

Background and Purpose:
Previous evidence that the Postural Assessment Scale for Stroke (PASS) and the Berg Balance Scale (BBS) have similar responsiveness is doubtful. Compared with the BBS, the PASS has more items assessing basic balance abilities (such as postural transition during lying and sitting), so it should be more likely to detect changes in patients with severe balance deficits. We aimed to compare the responsiveness of the PASS and the BBS in patients with stroke who have severe balance deficits.

Methods:
The PASS and BBS scores of 49 patients with severe balance deficits at 14 and 30 days after stroke were retrieved. The group-level responsiveness was examined with the standardized response mean (SRM). The individual-level responsiveness was examined by the proportion of patients who achieved clinically significant improvements (ie, their pre-post change scores in the PASS/BBS exceeded the minimal detectable change with 95% confidence of each measure). The responsiveness of the 2 measures was compared using the bootstrap approach.

Results and Discussion:
The comparisons of responsiveness showed significant differences between the PASS and the BBS at both the group and individual levels. At the group level, the PASS indicated moderate changes in balance function (SRM = 0.79), but the BBS indicated only small changes (SRM = 0.39). At the individual level, the PASS showed that 42.9% of patients had clinically significant improvements, while the BBS showed that only 6.1% of patients had clinically significant improvements.

Conclusions:
Compared with the BBS, the PASS was better able to detect balance improvements in patients having severe balance deficits. The PASS is recommended as an outcome measure to detect change in balance in patients with stroke who have severe balance deficits.
Anaplastic thyroid carcinoma diagnosed after treatment of lenvatinib for papillary thyroid carcinoma
Authors: Yamazaki Haruhiko , Iwasaki Hiroyuki , Suganuma Nobuyasu , Toda Soji , Masudo Katsuhiko , Nakayama Hirotaka , Rino Yasushi , Masuda Munetaka 
Published: October 2019

Summary
Anaplastic transformation of a primary thyroid tumor whose process can be followed is rare. The objective this study is to report a case of anaplastic transformation of locally advanced papillary thyroid carcinoma after treatment with lenvatinib. A 74-year-old woman consulted a local physician because of cough and bloody sputum. Thyroid cancer with tracheal invasion was suspected on computed tomography (CT) imaging, and she visited our hospital for treatment. We suspected anaplastic thyroid cancer (ATC) and core needle biopsy was performed. Histologic sections of the core needle biopsy showed that the tumor formed a papillary structure, and we diagnosed papillary thyroid carcinoma. Surgery would have been difficult, and we initiated lenvatinib at a low dose of 8 mg/day. CT on day 40 of lenvatinib treatment revealed that the thyroid tumor had shrunk remarkably. CT on day 111 revealed that tumor regrowth and tracheal invasion had been exacerbated. Core needle biopsy was performed, and histologic sections of the core needle biopsy that was performed after regrowth of the tumor showed that individual cancer cells had large, irregular nuclei, and necrosis was also observed. The immunohistochemical findings were negative for thyroglobulin, and only a few cells were positive for thyroid transcription factor 1, and we diagnosed ATC. Anaplastic transformation of the target lesion may be one of the causes of lenvatinib treatment failure in differentiated thyroid carcinoma.

Learning points:

Anaplastic transformation of a primary thyroid tumor whose process can be followed is rare.

The resistance mechanism of lenvatinib in treatment for differentiated thyroid carcinoma has not been clarified.

Anaplastic transformation of the target lesion may be one of the causes of lenvatinib treatment failure in differentiated thyroid carcinoma.
Natural Genetic Variation Screen inDrosophilaIdentifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis
Authors: Palu Rebecca A S , Ong Elaine , Stevens Kaitlyn , Chung Shani , Owings Katie G , Goodman Alan G , Chow Clement Y 
Published: October 2019

AbstractApoptosis is the primary cause of degeneration in a number of neuronal, muscular, and metabolic disorders. These diseases are subject to a great deal of phenotypic heterogeneity in patient populations, primarily due to differences in genetic variation between individuals. This creates a barrier to effective diagnosis and treatment. Understanding how genetic variation influences apoptosis could lead to the development of new therapeutics and better personalized treatment approaches. In this study, we examine the impact of the natural genetic variation in the Drosophila Genetic Reference Panel (DGRP) on two models of apoptosis-induced retinal degeneration: overexpression of p53 or reaper (rpr). We identify a number of known apoptotic, neural, and developmental genes as candidate modifiers of degeneration. We also use Gene Set Enrichment Analysis (GSEA) to identify pathways that harbor genetic variation that impact these apoptosis models, including Wnt signaling, mitochondrial metabolism, and redox homeostasis. Finally, we demonstrate that many of these candidates have a functional effect on apoptosis and degeneration. These studies provide a number of avenues for modifying genes and pathways of apoptosis-related disease.
¿La caries dental afecta la economía en el hogar?
Authors: Munayco Pantoja Evelyn Del Rosario , Cadillo Ibarra Marleny Marianela 
Published: October 2019

Sr. Editor.
La caries dental es la enfermedad más prevalente entre la población infantil y es la principal causa de consulta en los establecimientos del Ministerio de Salud 1. Los costos de tratamiento pueden ser altos, especialmente para los casos más graves, que pueden requerir un tratamiento extenso bajo anestesia general. En el Instituto Nacional de Salud del Niño (INSN), el Seguro Integral de Salud (SIS) solo cubre el 59,89% de los costos de sala de operaciones por tratamiento dental, el restante es cubierto por las familias.