bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Long-Term Impact of Single Intraoperative Instillation of Pirarubicin after Radical Nephroureterectomy on Local and Systemic Cancer Control: A Prospective, Multicenter, Randomized Trial
Authors: Suzuki Toru , Kanematsu Akihiro , Tanaka Shiro , Kanamaru Sojun , Yamasaki Toshinari , Kawakita Mutsushi , Yamamoto Shingo 
Published: December 2024

Abstract

Purpose: Although the preventive effect against intravesical recurrence (IVR) has been established for single instillation of chemotherapy during or after radical surgery of upper urinary tract urothelial carcinoma (UTUC), there has been no research on the long-term outcome. This study aims to investigate the IVR and long-term survival outcome of a single intraoperative instillation of pirarubicin during radical nephroureterectomy (RNU).
Methods: In this prospective, multicenter, randomized trial, 97 patients undergoing RNU between August 2012 and January 2019 were randomly assigned either to receive a single intraoperative pirarubicin instillation or to serve as the controls.
Results: A total of 80 patients were analyzed, including 42 in the pirarubicin group and 38 in the control group. The median follow-up period was 58.5 months and 62 months in the pirarubicin and the control groups, respectively. In patients who did not experience IVR, the median follow-up period was 59 months and 61 months in the pirarubicin and the control groups, respectively. There was no significant difference in OS between the two groups, although the IVR rate was significantly lower in pirarubicin group (p = 0.044). Multivariable analyses revealed that the pirarubicin instillation was the only independent factor for IVR.
Conclusions: The present trial demonstrated that a single intraoperative instillation of pirarubicin resulted in a significant and long-term reduction of IVR, although there was no significant difference in OS.
Use of a portable anthropometer to assess body weight, body movement, and crying frequency in newborns: An observational study
Authors: Suzuki Tomoo , Saito Kotoko , Ono Masanori , Nishibukuro Maria , Nara Shonosuke , Suganami Yusuke , Yamanaka Gaku , Oshima Kumi , Yachi Kaoru , Nemoto Tetsu , Sakai Yosuke , Kojima Junya , Kuji Naoaki , Nishi Hirotaka , Shimada Keiko 
Published: December 2024

Abstract

Background
Developmental support for newborns is a global public health concern. Neonatal body movements serve as key indicators of overall health, playing a pivotal role in neurodevelopment. Conventional methods of assessing newborn body movements are subjective, with limited accuracy and reliability. In this study we investigated the correlation between body weight and movements using an originally developed, portable, and battery-powered device. We also explored the relationship between the frequency of newborn cries and their body weight.
Methods
This observational study enrolled newborns collected from two university hospitals from August 2022 to November 2023. Movement was measured using a body movement measuring device equipped with piezoelectric sensors, a foot switch, and acceleration inputs. Body movements were represented as piezoelectric peaks. Correlation and regression analyses explored the relationships among neonatal body weight (at the time of the study), body movement, crying frequency, and crying duration.
Results
A positive correlation was identified between body weight and number of body movements (R2 = 0.2884). The regression analysis revealed a linear relationship between body weight and body movements per minute, and body weight and the number of cries per hour. Crying time also increased with increasing body weight (R2 = 0.5079).
Conclusions
Overall, these results indicate that the body movement measuring system allowed the non-invasive detection of neonatal body movements, establishing a robust positive correlation between body weight and the number of body movements. This method may offer an accurate and objective means to assess newborn body movements and crying frequency to identify at-risk infants who require early intervention.
Impact of supplementing Lactobacillus fermentum MN–LF23 on the eradication of Helicobacter pylori with 14–day standard quadruple therapy: A randomized, double–blind, placebo–controlled trial
Authors: Zhao Yuyang , Niu Xiaokang , Zhang Yong , Zhao Liang , Zhang Liwei , He Jingjing , Zhang Qi , Mao Yuejian , Wang Fuqing , Zhao Xiaohui , Wang Ran 
Published: December 2024

Abstract

Background: The effect of probiotics onHelicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role of Lactobacillus fermentum MN–LF23 (MN–LF23) in Hp–infected populations.
Methods: A total of 94 adult patients with confirmed Hp infection were enrolled in this study and randomly allocated to the placebo or MN–LF23 group. Patients initially received either placebo or probiotics along with standard quadruple therapy for 2 weeks, followed by continued administration of either placebo or probiotics for an additional 4 weeks. The eradication of Hp, serum levels of inflammatory factors, and alterations in gastrointestinal symptoms were assessed at weeks 0, 2, and 6, while fecal samples were collected for metagenomic sequencing.
Results: The results showed no significant difference (P = 1) in the eradication rate between the placebo group (85.11%) and the probiotic group (82.98%). Following treatment, the incidence of constipation, dyspepsia, and Gastrointestinal Symptom Rating Scale (GSRS) scores in the probiotic group were markedly lower (P < 0.05) compared to those observed in the placebo group. Throughout the treatment process, there were no significant differences in TNF–α and IL–1β levels between the two groups. Compared to the placebo group, the probiotic group exhibited a significant increase in beneficial bacteria such as Lactobacillus fermentum, Lactobacillus plantarum, Bifidobacterium longum, Coprococcus caltus, and Clostridium butyricum.
Conclusion: MN–LF23 supplementation did not improve the eradication rate of standard quadruple therapy. However, it significantly reduced the overall GSRS score, improved digestive and constipation symptoms, and promoted the proliferation of beneficial bacteria in the intestine.
Identification of Two Biological Subgroups of Complex Regional Pain Syndrome Type 1 by Transcriptomic Profiling of Skin and Blood
Authors: Valdés Melina Pérez Vertti , Jüngel Astrid , Bitterli Pamela , Devan Jan , Rehrauer Hubert , Opitz Lennart , Sirucek Laura , Schweinhardt Petra , Catanzaro Sabrina , Distler Oliver , Brunner Florian , Dudli Stefan 
Published: December 2024

Abstract

Background
Patients with Complex Regional Pain Syndrome (CRPS) present prolonged, debilitating pain and functional impairment. Treatments are not disease-modifying due to the poorly understood underlying pathomechanisms. This study aimed to identify the molecular signatures of potential CRPS type 1 subgroups.
Methods
Twelve women with CRPS type 1 were included. Demographics and pain questionnaires were recorded. Skin biopsies of the affected and non-affected limbs (n = 6 + 6) and peripheral blood (n = 11) were collected. RNA sequencing was performed on skin and peripheral blood mononuclear cells (PBMCs). Twenty cytokines were quantified in blood plasma (n = 12).
Results
Cluster analysis of the affected skin identified two CRPS subgroups (SG). SG1 exhibited increased gene expression related to epidermal development, metabolic processes, and a greater abundance of keratinocytes. SG2 showed enhanced transcriptomic changes in inflammatory, immune, and fibrotic processes, along with higher abundance of fibroblasts, macrophages, and endothelial cells. PBMCs transcriptomics revealed the same SG1/SG2 clusters and highlighted a stronger inflammatory response in the blood of SG1, suggesting distinct tissue-specific immune responses for the subgroups. Interleukin-1 receptor antagonist (IL-1RA) levels were higher in the blood plasma of SG1 (FDR = 0.01), consistent with its encoding gene IL1RN expression in PBMCs (log2 FC = 1.10, P < 0.001) and affected skin (log2 FC = 0.88, P = 0.006). Subgroups did not differ in demographic or clinical parameters but correlations among clinical factors varied between them.
Conclusions
This study identified two biological subgroups of CRPS type 1 through skin and blood transcriptomic profiling, advancing the understanding of this condition. This could facilitate the development of targeted treatments for CRPS type 1.
Determination of the Relationship between Hyperemesis Gravidarum and Systemic Inflammation Markers: A Case-Control Study
Authors: Adıgüzel Fikriye Işıl , Altınkaya Serhat , Kükrer Sadık , Nessar Ahmet Zeki , Uysal Gülsüm , Adıgüzel Cevdet 
Published: December 2024

Abstract

Background
We planned our study to investigate the relationship between HEG and inflammation markers like NLR, PLR and MLR.
Materials ant method:
A total of 150 pregnant women diagnosed with HEG and 150 controls were included in our study. Data were analyzed for demographic variables, complete blood count results, and urinary ketonuria levels.
Results
We found NLR, PLR and MLR to be significantly higher in HEG patients than controls (p < 0.05), indicating a potential role of systemic inflammation in HEG pathophysiology. ROC analysis revealed moderate discrimination powers for these markers, suggesting their utility as adjunctive diagnostic tools in clinical settings. However, no correlation was found between inflammatory markers and the severity of ketonuria.
Conclusions
NLR, PLR and MLR values ​​can be used as indicator for HEG as a result of the inflammatory process in HEG group.
Metabolism of Cannabidiol in Respiratory Associated Cells and HepG2- derived cells and Molecular Docking of Cannabidiol and its Metabolites with CYP Enzymes and Cannabinoid-2 Receptor
Authors: Tongkanarak Krittawan , Paul Pijush Kumar , Bintang Muhammad A. Khumaini Mudhar , Suedee Roongnapa , Sawatdee Somchai , Srich Teerapol 
Published: December 2024

Abstract

Cannabidiol (CBD) has been reported in medical applications for various indications. The enzymatic metabolism of CBD is not fully understood in the different routes of administration. This research aimed to identify the CBD metabolites after incubation of CBD with derived hepatocyte cells (HepG2), bronchial epithelial cells (NCI-H358), alveolar cells (A549), and alveolar macrophage cells (NR8383). The LC-MS/MS method was developed to quantify the CBD and its metabolites. Molecular docking was employed to evaluate the binding affinity of CBD with different cytochrome P-450 (CYP) enzymes and further predict the implication of drug-drug interactions. CBD and major metabolites of CBD were also docked with CB2 receptors. The results revealed that only HepG2 cells metabolized CBD to 7-hydroxy-CBD (7-OH-CBD) and 7-carboxy-CBD (7-COOH-CBD), whereas other respiratory cell lines and alveolar macrophages were found to have mainly CBD in the incubated samples without any major metabolites. The CYP2C19 and CYP3A4 enzymes were responsible for CBD conversion to hydroxylated CBD metabolites. The 7-OH-CBD and 7-COOH-CBD metabolites were found to bind to CB2 receptors with different affinities. The relative abundance of CBD and major metabolites may indicate the potential route of CBD administration.
Greater effort, greater pain: Givers’ feelings of social exclusion in gift failures across close and distant relationships
Authors: Lyu Dong , Wang Zhongfeng , Song Rongrong , Jin Jia 
Published: December 2024

Abstract

In gift-giving, it violates social norms for recipients to explicitly deliver negative evaluations of gifts, potentially causing emotional or psychological harm to givers, which raises ethical concerns. However, recent research indicates that this behavior is surprisingly common among young adults. While substantial research has focused on instances where recipients are dissatisfied with gifts, little attention has been given to the unique emotional harm experienced by givers and the underlying psychological processes involved. This study addresses this gap from the perspective of social exclusion and examines how givers’ feelings of social exclusion differ between close and distant relationships. We argue that givers tend to devote more effort to selecting gifts for close (vs. distant) recipients, leading them to hold higher expectations of gifting success in close relationships. Instead, when givers get negative feedback from close recipients, they perceive a higher level of expectancy violation, which, in turn, backfires on their perceived threats to the relationship and arouses stronger feelings of social exclusion than in distant relationships. Results from three experiments substantiate our theoretical claims based on the expectancy-violation theory. Further, we apply neuroscience technology (event-related potentials, ERPs) to capture the cognitive characteristics of givers’ emotional experiences, offering additional evidence and insights into givers’ feelings of social exclusion. This research contributes to a deeper understanding of the emotional harm givers experience when their gifts are unappreciated, highlighting the ethical aspect of gift-giving.
The Association between Social Media Use and Age, Sex, Self-esteem and Self-consciousness in University Students
Authors: Adams Sherifdeen , Alhassan Salisu 
Published: December 2024

Abstract

Introduction:
Over the last decade, social media usage has become a progressively common leisure activity. Even though social media use is not problematic to most people, some users seem to be involved in it addictively and/or compulsively.
Aims
The study sought to examine the association between social media use and age, sex, self-esteem and self-consciousness in university students.
Methods
The study adopted a correlational design. Forty-six (N = 46) students of different nationalities in the United Kingdom university population completed the Bergen Social Media Addiction Scale (BSMAS), Rosenberg Self-Esteem Scale (RSES) and Self-consciousness Scale-Revised (SCSR) through an online questionnaire. Data were analyzed using SPSS, with results presented through frequencies, percentages, mean, standard deviation and multiply regression model. Statistical significance was set at 0.05, with 95% confidence intervals assessed.
Results
The study found that variables such as Self-Esteem (p < .02) and Self-Consciousness (p < .01) had a significant association with Social Media Use. The other covariates were not statistically significant.
Conclusion
Spending a lot of time on social media can impact university students’ self-esteem and self-consciousness.
Precise modulation of electron spin states in metal-organic framework towards exceptional oxygen evolution reaction
Authors: Huang Minghua , Hou Xianbiao , Ni Tengjia , Zhang Zhaozheng , Zhou Jian , Zhang Shucong , Dai Shuixing , Chu Lei , Wang Huanlei , Huang Bolong 
Published: December 2024

Abstract

Spin configuration and coordination environment changes have emerged as promising strategies to boost the oxygen evolution reaction (OER) activity. However, achieving the precise and gradual regulation of both spin states and coordination environment to elucidate the structure-activity relationship remains a key priority and is rarely reported. In this work, we successfully induce the gradual transition of spin states of Fe sites from low spin state to a medium spin state and ultimately to high spin state by meticulously adjusting coordination environment within NiFe-MOF, while the Ni sites still keep a low spin state. Experimental and theoretical calculations confirm the precise regulation of spin polarization and electrons migration from the Fe-t2g to the Fe-eg orbitals with a reduced coordination saturation, which optimizes the spin orbital exchange interactions between Fe and Ni ions and facilitates adsorption of reaction intermediates. The NiFe-MOF-D3 with unique NiO6-FeO4 geometric structure exhibits low overpotential of 328 mV@1 A cm-2 and 365 mV@1.5 A cm-2 in alkaline medium. Furthermore, the assembled alkaline electrolyzer also presents remarkable activity (1.77 V@500 mA cm-2) and lower cost ($ 0.94) than the target of U.S. Department of Energy ($ 2.00).
The First Non-Pyrophoric Precursor for the Low Temperature Deposition of Metallic Aluminium
Authors: Knapp Caroline , de Faria Erica Neves , Douglas Samuel , Mrig Shreya , Santoni Leonardo , Clancy Adam , Wilson Daniel 
Published: December 2024

Abstract

The development of microelectronics prompts a search for precursors that can deposit conductive features. There is scarce research focusing on Al as it is normally deposited using pyrophoric and highly air- and moisture-sensitive AlH3 etherates or aminates. By careful consideration, ligands can impart increased stability while maintaining the ability to deposit the target materials. To this end, we have engineered an aluminium complex that can undergo reductant-free conversion to Al(0) at 100°C. Our strategy utilized multi-step synthetic design featuring β‑ketoiminate (acnac) bidentate ligands, [Al(R-acnac)2Cl] (R = Me, Et, iPr, Ph and Mes, 1-5) that were used as starting materials to obtain aluminium hydride complexes: the polymeric amidoalane Li[AlH2(iPr‑Hacnac)AlH3]n (6) and the imidoalane cluster [AlH2AlH2(N‑Mes)3(AlH2 ּ Li(Et2O)2)2] (8). When heated under vacuum at 100°C, 8 decomposes into aluminium metal, confirmed by XRD, TEM, XPS. This represents the first instance of a route to metallic aluminium involving non-pyrophoric precursors at low temperature.
Pathogenetic significance of IL-6 in children with vitamin D deficiency in COVID-19
Authors: Huseynova Ilhama , Qazanfar Hasanov Alakbar , Makhmud Mammadova Fakhriya , Adil Gafarov Ismayil 
Published: December 2024

Abstract

Scientific studies on the relationship between vitamin D levels and inflammatory markers in children are scarce today. The aim of this study is to compare the relationship of vitamin D level with inflammatory marker - IL-6 in children with COVID-19 (PCR positive) and its role in the clinical development of the disease. The examination included 90 children aged 1 to 17 years. The test for SARS-CoV-2 virus RNA was positive in the pathological material from the nasopharynx in 75 patients. The control group consisted of 15 healthy children. Examination methods included anamnestic, clinical, instrumental and laboratory studies. During the study, the level of vitamin D was assessed according to two parameters: the degree of vitamin D and the diagnosis of COVID-19. In both groups, the level of the inflammatory marker IL-6 was assessed. As a result, COVID-19 disease in children, as well as vitamin D levels were considered as factors that play an important role in the change of IL-6 level.
Proteomic profiling of the serological response to a chemically-inactivated nodavirus vaccine in European sea bass Dicentrarchus labrax
Authors: Chérif Nadia , Ghedira Kais , Agrebi Houda , Najahi Semah , Mejri Hiba , Azouz Saifeddine , Kielbasa Mélodie , Armengaud Jean , Kangethe Richard Thiga , Wijewardana Viskam , Bouhaouala-Zahar Balkiss , Sghaier Haitham 
Published: December 2024

Abstract

Analysing animal responses to immunization is pivotal in vaccine development by evaluating immune response, assessing vaccine safety and efficacy, and providing crucial insights into immune protection mechanisms. These insights are indispensable for advancing vaccines through trial stages and regulatory approval processes, as well as deciphering the molecular signatures of approved vaccines, which not only enhances our understanding of existing vaccines but also informs the rational design of new ones. This study aims to elucidate alterations in protein abundance patterns in the sera of European sea bass, Dicentrarchus labrax, following immunization with a chemically-inactivated nodavirus vaccine. The shotgun proteome comparison revealed that in vaccinated animals, compared to controls, there is a modulation of the redox balance favouring reactive oxygen species, an intricate interplay between coagulation and the immune system resulting in the under-abundance of hematopoiesis-related FLT3, and indications of functional adaptive immunity demonstrated by the under-abundance of pentraxin fusion protein-like and the over-abundance of myosins. To the best of our knowledge, this study represents the inaugural investigation of the immune response in fish using a proteomics approach, employing D. labrax as the host and nodavirus as the pathogen used for vaccination and challenge.
Space-based Reflectors for Night-time Illumination and Enhancing Solar Power Generation over India
Authors: Sakuru Sai Krishna V. S. , Ramana M. V. 
Published: December 2024

Abstract

Climate change agreements to contain global warming caused by greenhouse gas (GHG) emissions from fossil fuel-based sources necessitate a shift to renewables for energy generation. India's growing population drives her energy consumption and is predicted to peak by 2060. However, India’s per capita consumption of primary energy (7,129 kWh/yr in 2022) and electricity (1,311 kWh/yr) is much lower than for developed countries. Parity in per capita consumption by 2060 implies an increase in primary energy consumption by 56,277 TWh and the installed capacity for power generation by 2,482 GW from 2022 levels, and requires innovative carbon-neutral/low-carbon solutions. Sunlight reflected from space-based orbiting satellite reflectors (OSRs) can provide night-time illumination and enhance power generation from Solar Power Parks (SPPs) during dawn/dusk when natural sunlight is minimal. A constellation of 9 (34) pairs of OSRs with a mirror diameter of 1 km can provide continuous illumination ≥ 2 lux (≥ 8 lux) over New Delhi and illuminate other significant cities. OSRs in sun-synchronous dawn/dusk orbit at 1000 km altitude can increase power generation from SPPs by about 72.8 kWh/km2 during overhead passes. Our results indicate the potential for OSRs to meet future energy demand and reduce GHG emissions from the power sector.
The Nexus of Video Gaming Experiences: The Associations Among Basic Needs in Games, Real-Life Basic Needs, Well-Being Indicators, and Problematic Online Gaming
Authors: Subasi Mustafa , Gürkan Emre , Karaman Hakan , Bulut Sefa , Osin Evgeny N. 
Published: December 2024

Abstract

Recent research highlights the vital roles of basic needs in video gaming experiences. Both need-supportive and need-frustrating video gaming experiences have theoretical and practical implications for real-life need satisfaction and frustration, and well-being outcomes. This study aimed to adapt the Basic Needs in Games Scale (BANGS) into Turkish, tested the psychometric properties of “gaming in general” and “gaming in a particular game” versions of the Turkish BANGS, and investigated the associations among the BANGS, problematic online gaming, life satisfaction, meaning in life (i.e., coherence, purpose, significance), and real-life basic psychological needs. This study recruited a sample of 247 Turkish-speaking participants who played at least a video game over the past two weeks. The results provided evidence for the structural validity of the Turkish BANGS versions, and demonstrated good reliability for the BANGS subscales. The findings indicated that indicators of need satisfaction and frustration in games were primarily associated with their real-life counterparts, and showed complex associations with life satisfaction, meaning in life, and problematic online gaming. The implications for further research on basic needs in video games are discussed.