bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic Detailing to Reduce Sedative-Hypnotic Prescribing in Older Veterans
Authors: Ragan Addison P. , Aikens Garrett B. , Bounthavong Mark , Brittain Kevin , Mirk Anna 
Published: August 2019

Background: Sedative-hypnotics, including benzodiazepines (BZDs) and benzodiazepine receptor agonists (BZD-RA), are considered potentially inappropriate medications (PIMs) in older adults. Academic detailing, an educational outreach delivered by trained clinicians to other clinicians to encourage evidence-based care, can promote deprescribing of PIMs. Objective: To evaluate the impact of academic detailing on sedative-hypnotic prescribing to older veterans. Methods: A retrospective analysis was performed to evaluate the impact of academic detailing on BZD and BZD-RA prescribing to veterans aged 75 years and older. Prescribing trends for primary care and mental health prescribers in the Veterans Health Administration (VA) Southeast Network were calculated for the 18 months before and after an initial academic detailing session for each prescriber. Pre–post interrupted time series analyses (ITSAs) were conducted, and period prevalence was calculated as the number of prescriptions per 1000 older veterans. Results: A total of 155 prescribers were followed for 36 months. BZD prevalence declined by 23% (69.08-53.33 per 1000 population; P < .001) and by 15% for BZD-RA (18.07-15.38 per 1000 population; P < .001). New starts on BZD declined by 54% (2.36-1.09 per 1000 population; P < .001) and new starts on BZD-RA declined by 53% (1.02-0.48 per 1000 population; P < .001). Alternative medications for insomnia increased by 23% (39.98-49.27 per 1000 population; P < .001). Findings from the ITSA confirmed those of the pre–post analysis with sustained effects in the postintervention period. Conclusions: Academic detailing was associated with reduced sedative-hypnotic prescribing in the primary care and mental health setting.
Hospital Building and Departmental Area Calculation: Comparison of 36 Recent North American Projects
Authors: Lavy Sarel , Hamilton D. Kirk , Jiang Yin , Kircher Amy , Dixit M. K. , Lee Jin-Ting 
Published: August 2019

Background: Hospital trustees, administrators, and their consultants must base important budget decisions upon a projection of the size of proposed construction projects. The anticipated functions and an estimate of the space required are generally provided in a project program or project brief. The programming consultant, often part of the architect’s team, will calculate the physical area (square feet or square meters) required to perform the desired functions based on an understanding of demographics in the service area, services offered, the volumes of service required, and a historical understanding of space required to perform those services. Hospitals and hospital designs in North America have been changing. Plans must now address far higher percentages of outpatient care, accommodate new equipment modalities, and provide space to account for family presence in patient rooms. Aim: A study was undertaken to better understand whether the allocation of space in recently constructed hospital projects is different from the amounts of area devoted to various departments and functions in older projects. Method: In order to assure measurement consistency, a measurement methodology was developed and is reported elsewhere. Thirty-six recently constructed hospitals were measured. Results: The results provide new information about the allocation of space for nondepartmental functions within the overall building gross calculation. Many of the departmental space allocations fell within an expected range. Ultimately, significant detailed information about hospital area calculations is made available to the public because of this study.
Serial treatment of relapsed/refractory multiple myeloma with different BCMA-targeting therapies
Authors: Cohen Adam D. , Garfall Alfred L. , Dogan Ahmet , Lacey Simon F. , Martin Chris , Lendvai Nikoletta , Vogl Dan T. , Spear Matthew , Lesokhin Alexander M. 
Published: August 2019

Key Points
Myeloma patients progressing on BCMA-targeted therapy can maintain BCMA expression and still respond to different BCMA-targeted therapy. These observations suggest this patient population could be included in ongoing BCMA-targeted therapy trials.
Adolescents’ Contraceptive Use with School‐Discordant Partners: Exploring Individual‐ and Relationship‐Level Characteristics
Authors: Strully Kate , Kennedy David 
Published: August 2019

CONTEXTHeterosexual adolescents are less likely to use contraceptives when their partners are of different backgrounds or social circles. It is unclear why risky behaviors are more common within these relationships, and characteristics associated with school‐discordant partners—that is, partners who do not attend the adolescent's school—are particularly understudied.METHODSCharacteristics of romantic relationships and contraceptive use were examined among 1,043 female and 961 male respondents in Waves 1 (1994–1995) and 2 (1996) of the National Longitudinal Study of Adolescent to Adult Health. Generalized linear regression and structural equation models identified individual‐ and relationship‐level characteristics that were associated with school‐discordant relationships and contraceptive use.RESULTSFor females, the likelihood of ever having used a condom with a partner was reduced when that partner had not attended her school at the start of the relationship (odds ratio, 0.5) or when he was two or more years older (0.6). Notably, however, having a school‐ or age‐discordant partner was not associated with ever having used hormonal or dual methods for females, or with any contraceptive measures for males. For females, lower emotional intimacy with school‐discordant partners was positively associated with ever having used condoms with such partners (1.2).CONCLUSIONSCharacteristics of school‐discordant relationships are correlated with condom use in varying and sometimes countervailing ways. Future research examining the mechanisms linking school discordance to decreased condom use, particularly for females, would deepen understanding of the emotional and psychosocial processes involved in adolescents’ sexual and contraceptive behavior.
Ethiopian Categories, British Definitions: British Discovery of Ethiopian Identities from the Nineteenth Century to the First Decade of the Twentieth Century
Authors: Yates Brian J. 
Published: August 2019

Abstract
This essay examines correspondence in the British Foreign Office Archive to explore British views of Ethiopian identities during the nineteenth and early twentieth centuries. The premise of the paper is that during this time, British officials used group identities to help determine which Ethiopian leaders might make the best allies in furtherance of British strategic and economic interests. In essence, the British correspondents created and continually redefined ethnic categories as a reflection of the provincial leaders’ willingness to serve British economic interests. In the mid nineteenth century, after freeing British subjects imprisoned by emperor Tewodros (ruled 1855–1868), British diplomats sought to identify another legitimate ruler of Ethiopia; in the process, they attributed characteristics to various Ethiopian groups which marked those groups as more or less “civilized.” By the late nineteenth century, this recasting of identities contributed to the racializing of Ethiopian territories. In defining and redefining the qualities of Ethiopian notables and groups according to their own economic, colonial or political needs, British sources created categories of actors which did not necessarily correspond to identities as understood and asserted by the populations of what would become the Ethiopian Empire.
A Roadmap to Applied Digital Heritage
Authors: Harrison Laura K 
Published: August 2019

The recent “digital turn” in archaeology has driven methodological advances and opened new research avenues, with wide ranging impacts at multiple scales. The proliferation of methods such as 3D imaging, remote sensing, laser scanning and photogrammetry has led to the datafication of archaeology [Caraher 2016: 467, Mayer-Schönberger et al. 2013: 73]. This process is most evident in research on digital surveying, data visualization, digital archiving, mapping, and image processing, which prioritize the creation and manipulation of large digital datasets. These research avenues often generate more intellectual traffic than “slow archaeology” routes [Caraher 2016], which adopt a reflexive approach to knowledge production, embrace the inherent complexity of digital datasets, emphasize craft modes of archaeological documentation [Perry 2015], and “highlight the value of small and properly contextualized data” [Kansa 2016: 466]. Confronting the growing tension between big data and slow archaeology will be an iterative process. It will evolve as researchers and other stakeholder groups assess the value of digital approaches to preserving, communicating, and interpreting the past as it relates to the present. This special issue of Studies in Digital Heritage is the outcome of a symposium at the 2018 Society for American Archaeology (SAA) conference in Washington, D.C., entitled “Digital Heritage Technologies, Applications, and Impacts.” The articles within contribute to this dialogue by critically assessing the challenges and successes of recent digital heritage projects in museums, teaching and fieldwork contexts.
Green Mussels (Perna viridis L.) Culture in Mangrove Area Potentially Impacted by Heavy Metal
Authors: Suyono Suyono , Shapawi Rossita , Narto Narto 
Published: August 2019

The purposes of this study are to investigate the types of different collectors and their most effective height of installation in the green mussels cultivation (Perna viridis L.) impacted by heavy metal pollution in mangrove and non-mangrove waters; and to determine the content of heavy metals, especially Pb, Cu, Cd, and Hg in green mussels cultivation. This research was conducted from April to September 2018 in the coastal area of Karangdempel, Losari Sub District, Brebes Regency. The method used in this research was experimental. The results showed that the growth of green mussels after 6 months period of maintenance reached 7-9 cm long, weighing 10-13 grams per head and yielded 23-30 heads per collector. The most effective mussel collector was net sacks installed at a height of 30 cm from the bottom of the water. The number of mussels per collector was more in mangrove location compared to those in the non-mangrove location, while their growth in length and weight were relatively the same. Heavy metal content in seawater and in the mussel meat are still within the permissible limits of the Indonesian National Standard, except for the Cu content in the mussel exceeding the allowable limit; but it was relatively still safe accoring to the Decree of the Director General of Drug Control and Food, Indonesian Ministry of Health, No. 03725/B/SK/1989. Pb content in sediments in both location of green mussels cultivation and the Cisanggarung River basin is still within the safe limits. The content of Cd, Cu, and Hg in sediments tends to be high. Heavy metal content both in mangrove and non-mangrove areas was not different as a result of mangrove reforestation dominated by seedlings and saplings with little influence on the quality of the water ecologically and economically.
Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve
Authors: Schultz Heidrun , Tibon Roni , LaRocque Karen F. , Gagnon Stephanie A. , Wagner Anthony D. , Staresina Bernhard P. 
Published: August 2019

AbstractHow do we recall vivid details from our past based only on sparse cues? Research suggests that the phenomenological reinstatement of past experiences is accompanied by neural reinstatement of the original percept. This process critically depends on the medial temporal lobe (MTL). Within the MTL, perirhinal cortex (PRC) and parahippocampal cortex (PHC) are thought to support encoding and recall of objects and scenes, respectively, with the hippocampus (HC) serving as a content-independent hub. If the fidelity of recall indeed arises from neural reinstatement of perceptual activity, then successful recall should preferentially draw upon those neural populations within content-sensitive MTL cortex that are tuned to the same content during perception. We tested this hypothesis by having eighteen human participants undergo functional MRI (fMRI) while they encoded and recalled objects and scenes paired with words. Critically, recall was cued with the words only. While HC distinguished successful from unsuccessful recall of both objects and scenes, PRC and PHC were preferentially engaged during successful versus unsuccessful object and scene recall, respectively. Importantly, within PRC and PHC, this content-sensitive recall was predicted by content tuning during perception: Across PRC voxels, we observed a positive relationship between object tuning during perception and successful object recall, while across PHC voxels, we observed a positive relationship between scene tuning during perception and successful scene recall. Our results thus highlight content-based roles of MTL cortical regions for episodic memory and reveal a direct mapping between content-specific tuning during perception and successful recall.
Apparent Genetic Rescue of AdultShank3Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments
Authors: Speed Haley E. , Kouser Mehreen , Xuan Zhong , Liu Shunan , Duong Anne , Powell Craig M. 
Published: August 2019

AbstractSHANK3(ProSAP2) is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan–McDermid syndrome (PMS). We performed genetic rescue ofShank3mutant phenotypes in adult mice expressing aShank3exon 21 insertion mutation (Shank3G). We used a tamoxifen-inducible Cre/loxP system (CreTam) to revertShank3Gto wild-type (WT)Shank3+/+. We found that tamoxifen treatment in adultShank3GCreTam+mice resulted in complete rescue of SHANK3 protein expression in the brain and appeared to rescue synaptic transmission and some behavioral differences compared toShank3+/+CreTam+controls. However, follow-up comparisons between vehicle-treated, WT Cre-negative mice (Shank3+/+CreTam−andShank3+/+CreTam+) demonstrated clear effects ofCreTamon baseline synaptic transmission and some behaviors, making apparently positive genetic reversal effects difficult to interpret. Thus, while theCreTamtamoxifen-inducible system is a powerful tool that successfully rescuesShank3expression in ourShank3G/Greversible mutants, one must exercise caution and use appropriate control comparisons to ensure sound interpretation.
Tonic Suppression of the Mesolimbic Dopaminergic System by Enhanced Corticotropin-Releasing Factor Signaling Within the Bed Nucleus of the Stria Terminalis in Chronic Pain Model Rats
Authors: Takahashi Daiki , Asaoka Yuta , Kimura Keisuke , Hara Ryuto , Arakaki Saya , Sakasai Keisuke , Suzuki Hiroe , Yamauchi Naoki , Nomura Hiroshi , Amano Taiju , Minami Masabumi 
Published: August 2019

Although dysfunction of the mesolimbic dopaminergic system has been implicated in chronic pain, the underlying mechanisms remain to be elucidated. We hypothesized that increased inhibitory inputs to the neuronal pathway from the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) during chronic pain may induce tonic suppression of the mesolimbic dopaminergic system. To test this hypothesis, male Sprague Dawley rats were subjected to spinal nerve ligation to induce neuropathic pain and then spontaneous IPSCs (sIPSCs) were measured in this neuronal pathway. Whole-cell patch-clamp electrophysiology of brain slices containing the dlBNST revealed that the frequency of sIPSCs significantly increased in VTA-projecting dlBNST neurons 4 weeks after surgery. Next, the role of corticotropin-releasing factor (CRF) signaling within the dlBNST in the increased sIPSCs was examined. CRF increased the frequency of sIPSCs in VTA-projecting dlBNST neurons in sham-operated controls, but not in chronic pain rats. By contrast, NBI27914, a CRF type 1 receptor antagonist, decreased the frequency of sIPSCs in VTA-projecting dlBNST neurons in the chronic pain rats, but not in the control animals. In addition, histological analyses revealed the increased expression of CRF mRNA in the dlBNST. Finally, bilateral injections of NBI27914 into the dlBNST of chronic pain rats activated mesolimbic dopaminergic neurons and induced conditioned place preference. Together, these results suggest that the mesolimbic dopaminergic system is tonically suppressed during chronic pain by enhanced CRF signaling within the dlBNST via increased inhibitory inputs to VTA-projecting dlBNST neurons.SIGNIFICANCE STATEMENTThe comorbidity of chronic pain and depression has long been recognized. Although dysfunction of the mesolimbic dopaminergic system has been implicated in both chronic pain and depression, the underlying mechanisms remain to be elucidated. Here, we show that the inhibitory inputs to the neuronal pathway from the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area increase during chronic pain. This neuroplastic change is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST that leads to tonic suppression of the mesolimbic dopaminergic system, which may be involved in the depressive mood and anhedonia under the chronic pain condition.
Cannabis Concentrate Use in Adolescents
Authors: Meier Madeline H. , Docherty Meagan , Leischow Scott J. , Grimm Kevin J. , Pardini Dustin 
Published: August 2019

BACKGROUND:
Cannabis concentrates, which are cannabis plant extracts that contain high concentrations of Δ-9-tetrahydrocannbinol (THC), have become increasingly popular among adults in the United States. However, no studies have reported on the prevalence or correlates of cannabis concentrate use in adolescents, who, as a group, are thought to be particularly vulnerable to the harms of THC.

METHODS:
Participants are a racially and ethnically diverse group of 47 142 8th-, 10th-, and 12th-grade students recruited from 245 schools across Arizona in 2018. Participants reported on their lifetime and past-month marijuana and cannabis concentrate use, other substance use, and risk and protective factors for substance use problems spanning multiple life domains (ie, individual, peer, family, school, and community).

RESULTS:
Thirty-three percent of all 8th-, 10th-, and 12th-graders reported lifetime cannabis use, and 24% reported lifetime concentrate use. Seventy-two percent of all lifetime cannabis users had used concentrates. Relative to adolescent cannabis users who had not used concentrates, adolescent concentrate users were more likely to use other substances and to experience more risk factors, and fewer protective factors, for substance use problems across numerous life domains.

CONCLUSIONS:
Most adolescent cannabis users have used concentrates. Based on their risk and protective factor profile, adolescent concentrate users are at higher risk for substance use problems than adolescent cannabis users who do not use concentrates. Findings raise concerns about high-risk adolescents’ exposure to high-THC cannabis.
A new genus of augochlorine bees from northern Venezuela (Hymenoptera: Halictidae)
Authors: Engel Michael S. 
Published: August 2019

A new genus and species of the bee tribe Augochlorini (Halictinae) is described and figured from northern Venezuela. Trichommation osculans Engel, new genus and species, is a member of the Megaloptidia-group of genera as evidenced by the narrow and elongate mouthparts and sharply pointed galeal apex. The genus is most similar to Megommation Moure and Megaloptidia Cockerell, particularly in the enlarged ocelli present only in these genera among those in the group. Aside from intermingling traits of both of these genera, Trichommation is further distinct from both owing to the presence of ocular setae, a pectinate inner metatibial spur, and basal rugae on the basal area of the propodeum. Emendations to the key to genera of the Megaloptidia group are provided to allow for the identification of Trichommation.
Analysis of the effectiveness of selection of women for coronarography in real clinical practice
Authors: Izmozherova N. V. , Popov A. A. , Sherstobitov V. E. 
Published: August 2019

Objective: evaluation of the effectiveness of selection for coronary angiography of women who have applied to a cardiologist for thoracalgia and dorsalgia and regarded primarily as having a clinic of stable angina.Materials and methods. 108 women (median age 59.5) applying to cardiologist due to chest pain were included in a cross-sectional study and underwent coronary angiography. Subjects with identified clinically significant atherosclerotic coronary lesions were compared to persons with intact coronary arteries.Results. One-, two- and three-vessel lesions were diagnosed in accordingly 16; 21 and 26 % of patients. Intact coronary arteries were detected in 37 % subjects. In 17 of 40 persons with intact structure of the coronary arteries spasm of the coronary arteries was diagnosed. Odds ratio for atherosclerotic coronary arteries lesions in type 2 diabetic persons were 7.91 (1.74–36.00), for hypertension odds ratio 4.79 (1.52–15.01). Severe angina (3 and 4 functional class) was significantly more often diagnosed in women with identified coronary atherosclerosis. Severe coronary atherosclerosis was associated with absence of negative or doubtful results, whereas intact coronary vessels, negative and questionable results revealed more than half of the women. The obtained data reflect the relevance of the development of more effective algorithms for diagnosis of coronary artery disease in women, since the gender peculiarities of the formation of coronary atherosclerosis have been clearly confirmed in a number of large studies.Conclusion. Medical history, physical load tests results, and subject’s emotional status should be evaluated to assess the feasibility of coronary angiography.
Bir Parametreli Eliptik Homotetik Düzlemsel Hareketler
Authors: AZAK Yrd. Doç. Dr. Ayşe Zeynep 
Published: August 2019

Bu
makalede bir parametreli eliptik homotetik düzlemsel hareket için türev
formülleri elde edildi. Daha sonra bu hareketin mutlak, izafe, sürüklenme hız
vektörleri ve bu vektörler arasındaki ilişkiyi ifade eden teorem verildi.
Ayrıca bir parametreli eliptik homotetik hareket için pol noktaları ve kanonik
izafe sistem tanımlandı. Son olarakta a1,a2 ve homotetik sabitin 1
olması durumlarında bazı önemli sonuçlar bulundu.
The Effect Of Fatigue And Sleepiness Upon Driver Behaviors
Authors: BAŞ Fatih İrfan , GÖKDAĞ Mahir 
Published: August 2019

Human factor has appeared as the most important factor in traffic
accidents. It has statistically been
revealed that the rate of defect in death and injuries of drivers, passengers
and pedestrians has reached up to 99%. This has necessitated the analysis of
human behaviors in traffic accidents as driver, pedestrian and passengers.

In this study, the effect
of fatigue and sleeplessness upon behaviors of drivers was investigated. Even
driving and resting periods’ being determined with legal regulations could not
provide drivers to display adequate level of sensitivity. And this caused
drivers to drive until service points or their destination, and therefore the
possibility of their being involved in an accident due to sleeplessness and
fatigue increased. Suggestions were offered to prevent and decrease these
considering the fatal results of traffic accidents.