bluuebunny/crossref_metadata_2025_split huggingface dataset:
perfectphyloR: An R package for reconstructing perfect phylogenies
Authors: Karunarathna Charith Bhagya , Graham Jinko 
Published: June 2019

AbstractBackgroundA perfect phylogeny is a rooted binary tree that recursively partitions sequences. The nested partitions of a perfect phylogeny provide insight into the pattern of ancestry of genetic sequence data. For example, sequences may cluster together in a partition indicating that they arise from a common ancestral haplotype.ResultsWe present an R packageperfectphyloRto reconstruct the local perfect phylogenies underlying a sample of binary sequences. The package enables users to associate the reconstructed partitions with a user-defined partition. We describe and demonstrate the major functionality of the package.ConclusionTheperfectphyloRpackage should be of use to researchers seeking insight into the ancestral structure of their sequence data. The reconstructed partitions have many applications, including the mapping of trait-influencing variants.
Non-Genetic Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype
Authors: Wofford Kathryn L. , Singh Bhavani S. , Cullen D. Kacy , Spiller Kara L. 
Published: June 2019

ABSTRACTMonocyte-derived macrophages orchestrate tissue regeneration by homing to sites of injury, phagocytosing pathological debris, and stimulating other cell types to repair the tissue. Accordingly, monocytes have been investigated as a translational and potent source for cell therapy, but their utility has been hampered by their rapid acquisition of a pro-inflammatory phenotype in response to the inflammatory injury microenvironment. To overcome this problem, we designed a cell therapy strategy where we collect and exogenously reprogram monocytes by intracellularly loading the cells with biodegradable microparticles containing an anti-inflammatory drug in order to modulate and maintain an anti-inflammatory phenotype over time. To test this concept, poly(lactic-co-glycolic) acid microparticles were loaded with the anti-inflammatory drug dexamethasone (Dex) and administered to primary human monocytes for four hours to facilitate phagocytic uptake. After removal of non-phagocytosed microparticles, microparticle-loaded monocytes differentiated into macrophages and stored the microparticles intracellularly for several weeksin vitro, releasing drug into the extracellular environment over time. Cells loaded with intracellular Dex microparticles showed decreased expression and secretion of inflammatory factors even in the presence of pro-inflammatory stimuli up to 7 days after microparticle uptake compared to untreated cells or cells loaded with blank microparticles. This study represents a new strategy for long-term maintenance of anti-inflammatory macrophage phenotype using a translational monocyte-based cell therapy strategy without the use of genetic modification. Because of the ubiquitous nature of monocyte-derived macrophage involvement in pathology and regeneration, this strategy holds potential as a treatment for a vast number of diseases and disorders.
Critical role for P53 in regulating the cell cycle of ground state embryonic stem cells
Authors: ter Huurne Menno , Peng Tianran , Yi Guoqiang , van Mierlo Guido , Marks Hendrik , Stunnenberg Hendrik G. 
Published: June 2019

AbstractMouse Embryonic Stem Cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1-phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs. Here we provide evidence that P53 is activated upon transition of serum ESCs to their pluripotent ground state using serum-free 2i conditions and modulates G1-phase progression. Our data shows that the elongated G1-phase characteristic of ground state ESCs is dependent on P53. RNA-seq and ChIP-seq analyses reveal that P53 directly regulates the expression of the Retinoblastoma (RB) protein and that the hypo-phosphorylated, active RB protein plays a key role in G1-phase control. Our findings suggest that the P53-P21 pathway is active in ground state 2i ESCs and that its role in the G1-checkpoint is abolished in serum ESCs. Taken together, the data reveals a mechanism by which inactivation of P53 can lead to loss of RB and uncontrolled cell proliferation.
Social capital and export performance of SMEs in Ghana: the role of firm capabilities
Authors: Easmon Roseline Barbara , Kastner Adelaide Naa Amerley , Blankson Charles , Mahmoud Mahmoud Abdulai 
Published: June 2019

PurposeThe purpose of this paper is to understand the direct impact of social capital and the influence of market-based capabilities as intervening variables on the export performance of small and medium-sized enterprises (SMEs) in Ghana.Design/methodology/approachQuestionnaire-based survey was used to collect data from top executives and senior managers of exporting companies in Ghana. Data obtained were analysed using the structural equation modelling.FindingsThe findings revealed that social capital of SMEs exert the greatest influence on their export performance. Innovation and marketing capabilities are also key drivers of export performance among SMEs as they fully mediate the social capital–export performance relationship. Notwithstanding, marketing capabilities appear to exert a greater influence than innovation capabilities on the export performance of SMEs.Research limitations/implicationsThe study used perceptual measures of international performance by managers of SMEs in the Ghanaian exporting sector making it difficult to determine respondent bias.Practical implicationsManagers of exporting firms should build stronger relationships with their customers and suppliers who contribute significantly to their export performance. SMEs would also have to hone their innovation and marketing skills as strategic components in enhancing their export performance.Social implicationsMarket-based resources such as marketing and innovation should not be taken for granted by SMEs in the export business.Originality/valueThe study offers some lessons on how small firms can sharpen their marketing and innovation capabilities to derive export performance benefits from social capital. Theoretically, while the findings offer strong evidence reinforcing the DC theory, an exploration of the nexus of the theories brings to the fore the need to reassess the resource-based view and SC theories.
Exploring adaptive information sharing from the perspective of cognitive switching
Authors: Zha Xianjin , Yang Haijuan , Yan Yalan , Yan Guanxiang , Huang Chengsong , Liu Kunfeng 
Published: June 2019

PurposeMicroblogging as one kind of social media application provides an important information sharing platform. Adaptive information sharing is the combination of adaptive information technologies (IT) use behavior and information sharing behavior and subsequently refers to adaptive use of IT oriented to information sharing. The purpose of this paper is to understand adaptive information sharing in the context of microblogging from the perspective of cognitive switching.Design/methodology/approachA research model was developed and survey data were collected. The partial least squares structural equation modeling was employed to verify the research model.FindingsAdaptive information sharing is positively impacted by other people’s use, discrepancies and deliberate initiatives among which other people’s use is the key determinant. Meanwhile, task self-efficacy positively moderates the effect of other people’s use on adaptive information sharing.Practical implicationsDevelopers of microblogging should as far as possible create learning atmosphere and learning culture. With learning atmosphere and culture, more and more users could keep on learning from observing other people. Consequently, more and more users would be willing to try new features of microblogging to share information.Originality/valueThis study examines adaptive information sharing by extending adaptive IT use behavior from the levels of technology, system and feature to the information level, presenting a new lens for adaptive IT use and information sharing alike.
Modeling the interplay of information seeking and information sharing
Authors: Savolainen Reijo 
Published: June 2019

Purpose
The purpose of this paper is to contribute to the creation of a holistic picture of information behavior by examining the connections between information seeking and sharing.

Design/methodology/approach
Conceptual analysis is used to focus on the ways in which the researchers have modeled the interplay of information seeking and sharing. The study draws on conceptual analysis of 27 key studies examining the above issue, with a focus on the scrutiny of six major models for information behavior.

Findings
Researchers have employed three main approaches to model the relationships between information seeking and sharing. The indirect approach conceptualizes information seeking and sharing as discrete activities connected by an intermediating factor, for example, information need. The sequential approach assumes that information seeking precedes information sharing. From the viewpoint of the interactive approach, information seeking and sharing appear as mutually related activities shaping each other iteratively or in a cyclical manner. The interactive approach provides the most sophisticated research perspective on the relationships of information seeking and sharing and contributes to holistic understanding of human information behavior.

Research limitations/implications
As the study focuses on information seeking and sharing, no attention is devoted to other activities constitutive of information behavior, for example, information use.

Originality/value
The study pioneers by providing an in-depth analysis of the connections of information seeking and information sharing.
Development of an alcohol withdrawal risk stratification tool based on patients referred to an addiction liaison nursing service in Glasgow
Authors: Benson George , McPherson Andrew , McCallum Jacqueline , Roberts Nicola 
Published: June 2019

PurposeThe purpose of this paper is to develop an alcohol withdrawal syndrome risk stratification tool that could support the safe discharge of low risk patients from the emergency department.Design/methodology/approachA retrospective cohort study that included all patients referred to the acute addiction liaison nursing service over one calendar month (n=400, 1–30 April 2016) was undertaken. Bivariate and multivariate modelling identified the significant variables that supported the prediction of severe alcohol withdrawal syndrome (SAWS) in the cohort population.FindingsThe Glasgow Modified Alcohol Withdrawal Scale (GMAWS), hours since last drink, fast alcohol screening test (FAST) and systolic blood pressure correctly identified 89 per cent of patients who developed SAWS and 84 per cent of patients that did not. Increasing each component by a score of one is associated with an increase in the odds of SAWS by a factor of 2.76 (95% CI 2.21, 3.45), 1.31 (95% CI 1.24, 1.37), 1.30 (95% CI 1.08, 1.57) and 1.22 (95% CI 1.10, 1.34), respectively.Research limitations/implicationsThe research was conducted in a single healthcare system that had a high prevalence of alcohol dependence syndrome (ADS). Second, the developed risk stratification tool was unable to guarantee no risk and lastly, the FAST score previously aligned to severe ADS may have influenced the patients highest GMAWS score.Practical implicationsThe tool could help redesign the care pathway for patients who attend the emergency department at risk of SAWS and link low risk patients with community alcohol services better equipped to deal with their physical and psychological needs short and long term supporting engagement, abstinence and prolongation of life.Originality/valueThe tool could help redesign the care pathway for emergency department patients at low risk of SAWS and link them with community alcohol services better equipped to deal with their physical and psychological needs, short and long term, supporting engagement, abstinence and prolongation of life.
Learning from defects in the UK housing sector using action research
Authors: Hopkin Tony , Lu Shu-Ling , Sexton Martin , Rogers Phil 
Published: June 2019

Purpose
Maximising the benefit of learning from defects is regarded by UK housing associations (HAs) as a key opportunity to meet their challenges of building more homes with reduced government funding and rent incomes. Despite learning from defects being a frequent recommendation to reduce defects in the construction literature, there is scarce empirical evidence into how HAs actually learn from defects. The purpose of this paper is to better understand how HAs learn from past defects and induce change to reduce defects.

Design/methodology/approach
Guided by organisational learning (OL) as the theoretical lens, a 21-month action research (AR) project explored one HA’s defects management and learning processes.

Findings
OL has the potential to reduce defects in new homes but is a secondary task which is reliant on a defects management team analysing defect data to identify priority areas. As such, learning from defects can be reduced due to peaks in workload if data analysis is a manual process. Furthermore, a dual learning approach plays a significant role for HA’s learning consisting of designing out defects (codification) supported by networking (personalisation) to tackle issues of workmanship on site and those defects that cannot be designed out.

Originality/value
This study demonstrates OL has the potential to reduce defects in new homes but is a secondary task in HA’s practice; and highlights the practical challenges of academia and industry co-production in AR in construction.
Genetic algorithm for determining the construction logistics of precast components
Authors: Fang Yuan , Ng S. Thomas 
Published: June 2019

Purpose
Precast construction has become increasingly popular in the construction industry. Nonetheless, the logistics of construction materials has been a neglected topic, and this neglect has resulted in delays and cost overruns. Careful planning that considers all of the factors affecting construction logistics can ensure project success. The purpose of this paper is to examine the potential for using genetic algorithms (GAs) to derive logistics plans for materials production, supply and consumption.

Design/methodology/approach
The proposed GA model is based on the logistics of precast components from the supplier’s production yard, to the intermediate warehouse and then to the construction site. Using an activity-based costing (ABC) approach, the model not only considers the project schedule, but also takes into account the production and delivery schedule and storage of materials.

Findings
The results show that GAs are suitable for solving time-cost trade-off problems. The optimization process helps to identify the activity start time during construction and the delivery frequency that will result in the minimal cost. What-if scenarios can be introduced to examine the effects of changes in construction logistics on project outcomes.

Originality/value
This paper presents a method for using GAs and an ABC approach to support construction logistics planning decisions. It will help construction planners and materials suppliers to establish material consumption and delivery schedules, rather than relying on subjective judgment.
Integrating resilience engineering and UAS technology into construction safety planning and control
Authors: Rodrigues Santos de Melo Roseneia , Bastos Costa Dayana 
Published: June 2019

Purpose
The purpose of this paper is to present an exploratory study in order to understand the contributions of the resilience engineering (RE) concept and the use of unmanned aerial systems (UASs) technology to support the safety planning and control (SPC) process.

Design/methodology/approach
A case study on a construction project was conducted and involved the following steps: diagnosis of the SPC process; development of a safety monitoring protocol using UASs; and field tests to monitor safety performance using UASs and data analysis.

Findings
In terms of its theoretical contribution, this work presents a conceptual framework explaining how the RE and the UASs can contribute to the SPC process. Also, this paper provides, as a practical contribution, a protocol for safety monitoring with UASs integrated into the safety routine, highlighting the tasks that can be checked and unsafe conditions and safety/production conflicts identified through monitoring.

Practical implications
This study can be used to support and stimulate the construction managers who wish to adopt the RE concepts and UAS technology to improve safety management.

Social implications
An efficient SPC process can improve the work conditions at construction sites, contributing with the reduction of accidents rates.

Originality/value
The paper highlights the need to adopt new approaches, as RE concepts and UAS technology to support the SPC process, in order to improve safety conditions at construction sites.
How corporate governance and ownership affect banks’ risk-taking in the MENA countries?
Authors: Otero Luis , Alaraj Rafat , Lado-Sestayo Ruben 
Published: June 2019

Purpose
The purpose of this paper is to explore the relationship between corporate governance and risk-taking behaviour of banks operating in the Middle East and North African (MENA) countries.

Design/methodology/approach
In doing so, the authors use a data set covering 165 banks located in 13 MENA countries over the period 2005–2012 and apply dynamic panel data methodology.

Findings
The results show that good governance acting in the interests of shareholders could lead to excessive risk taking; in this sense, a conflict of interest between the stakeholders, interested in the solvency of the financial system, and shareholders, trying to maximise their benefit, may occur. The greater risk can be reinforced by the governance of the country and a strong macro governance framework can incentivise a higher risk exposure in banks, showing the influence of bank regulation and law enforcement on the risks taken by banks.

Originality/value
To the best of the authors’ knowledge, this is the first paper showing that corporate governance is relevant for explaining risk taking at the country and bank levels in MENA countries.
Investigating the determinants of firm performance
Authors: Kourtzidis Stavros , Tzeremes Nickolaos G. 
Published: June 2019

PurposeThe purpose of this paper is to use tenets of the complexity theory in order to study the effect of various determinants of firm’s performance, such as CEO’s compensation and age, for the case of 72 insurance companies.Design/methodology/approachThe authors identify the asymmetries in the data set by creating quantiles and using contrarian analysis. Instead of ignoring this information and use a main effects approach, all the available information in the data set is taken into account. For this purpose, the authors use qualitative comparative analysis to find alternative equifinal routes toward high firm performance.FindingsFive configurations are found which lead to high performance. Every one of the five configurations is found to be sufficient but not necessary for high firm performance.Originality/valueThe research findings contribute to a better understanding of the determinants of firm’s performance taking into account the asymmetries in the data set. The authors identify alternative paths toward high firm performance, which could be vital information for the decision maker inside a firm.
A qualitative study on motivators and barriers affecting entrepreneurship among Latinas
Authors: Cho Eunjoo , Moon Zola K. , Bounkhong Tiffany 
Published: June 2019

PurposeThe study aims to explore motivators and barriers in business venture creation among potential Latina entrepreneurs.Design/methodology/approachFocus group interviews collected data using Latinas between the ages of 20-30 who expressed interest in starting their own businesses in the near future. Interview participants were primarily first-generation college students.FindingsFindings revealed major themes based around four dimensions of cultural heritage, motivators, barriers and preferred resources. Cultural heritage and gender are both enablers and obstacles for Latinas. Frequently mentioned motivators were parental business ownership, autonomy, flexible income and self-fulfillment. The barriers include fear, lack of financial management knowledge, business location selection and discrimination. The preferred resources were informal education, a checklist, a toolkit, free online resources and networking with business owners and mentors.Research limitations/implicationsThe findings of this study highlight pull factors (i.e. family business background and self-fulfillment) increasing entrepreneurial motivations among Latinas. The present study illustrates the nuanced but substantive interactions of gender and ethnicity in Latinas’ perceptions and attitudes toward new business formation.Originality/valueThe present study contributes to the literature by exploring the motivators and barriers that affect business formation among emerging Latina entrepreneurs. Moreover, past research has not explored both motivators and barriers perceived by nascent Latina entrepreneurs. Findings from this study will assist future researchers in developing materials and programs to aid female and ethnic entrepreneurship.
Understanding customer-customer rapport in a senior group package context
Authors: Hwang Jinsoo , Lee JungHoon (Jay) 
Published: June 2019

Purpose
As the elderly population in Korea grows, sales of travel packages for elderly people are also increasing. Senior tourists should spend much time with other tourists because of the nature of package travel. Thus, the purpose of this paper is to investigate the significance of rapport with other tourists in the elderly tourist context. Specifically, the current study examined the relationship between other customer perceptions and rapport with other tourists. In addition, this study investigated the influences of rapport with other tourists on tour quality, tour satisfaction and word-of-mouth.

Design/methodology/approach
This paper collected data from 411 elderly tourists in Korea and conducted a structural equation modeling analysis to test nine hypotheses.

Findings
Physical appearance and suitable behavior positively affect rapport with other tourists and thus aid in increasing tour quality, tour satisfaction and word-of-mouth.

Originality/value
In service marketing, there is a general consensus that customers are influenced by other customers who use the same service facility because they recognize other customers as the environment of the service facility. The concept of other customer perceptions was applied to tourism marketing in this study in combination with another understudied concept, rapport. This study is one of the first, as per the authors’ knowledge, to apply those important concepts to the tourism industry in particular, although there has been a considerable body of research in the service marketing field. Consequently, the findings of this paper would be meaningful and useful for travel agencies when developing a marketing strategy to enhance rapport between tourists.