bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating foliar anthocyanin content of purple corn via hyperspectral model
Authors: Gu Xiaohe , Cai Wenqian , Fan Youbo , Ma Yue , Zhao Xiaoyan , Zhang Chao 
Published: February 2018

AbstractTo date, the foliar anthocyanin content was either determined via the pH differential or HPLC methods, both of which are slow and destructive. Here, a hyperspectral model was established to estimate the foliar anthocyanin content of purple corn (Zea mays L. var. Jingzi No. 1). The reflectivity (P) of the foliar hyperspectral was inverted to 1/P, lg P, 1/lg P, , , , and . The correlation coefficient between these inversions and the foliar anthocyanin content was plotted against the hyperspectral wavelength. The wavelength of inversions around 650 nm was sensitive to the foliar anthocyanin content. The hyperspectral model was fitted via linear, polynomial, power, exponential, and logarithmic functions with the sensitive band as independent variable and the anthocyanin content as function. The hyperspectral model (y = 3,000,000,000 × W6854.5896) fitted via inversion of showed the highest determination coefficients (0.768) among all models. The hyperspectral model was well validated with a determination coefficient of 0.932 and an RMSE of 0.0065. Moreover, the accuracy and stability of the hyperspectral model were further enhanced with a determination coefficient of 0.954 and RMSE of 0.0047 when the anthocyanin content of the sample was below 20 mg/g. Hence, the hyperspectral model estimated the foliar anthocyanin content of purple corn quickly and nondestructively.
Mutations in the PH Domain of DNM1 are associated with a nonepileptic phenotype characterized by developmental delay and neurobehavioral abnormalities
Authors: Brereton Emily , Fassi Emily , Araujo Gabriel C. , Dodd Jonathan , Telegrafi Aida , Pathak Sheel J. , Shinawi Marwan 
Published: February 2018

AbstractBackgroundDynamin 1 is a protein involved in the synaptic vesicle cycle, which facilitates the exocytosis of neurotransmitters necessary for normal signaling and development in the central nervous system. Pathogenic variants in DNM1 have been implicated in global developmental delay (DD), severe intellectual disability (ID), and notably, epileptic encephalopathy. All previously reported DNM1 pathogenic variants causing this severe phenotype occur in the GTPase and Middle domains of the dynamin 1 protein.MethodsWe used whole‐exome sequencing to characterize the molecular basis of DD and autistic symptoms in two identical siblings.ResultsThe twin siblings exhibit mild to moderate ID and autistic symptoms but no epileptic encephalopathy. Exome sequencing revealed a genetic variant, c.1603A>G (p.Lys535Glu), in the PH domain of dynamin 1. Previous in vitro studies showed that mutations at Lys535 inhibit endocytosis and impair PH loop binding to PIP2.ConclusionsOur data suggest a previously undescribed milder phenotype associated with a missense genetic variant in the PH domain of dynamin 1.
Genotype–phenotype investigation of 35 patients from 11 unrelated families with camptodactyly–arthropathy–coxa vara–pericarditis (CACP) syndrome
Authors: Yilmaz Saliha , Uludağ Alkaya Dilek , Kasapçopur Özgür , Barut Kenan , Akdemir Ekin S. , Celen Cemre , Youngblood Mark W. , Yasuno Katsuhito , Bilguvar Kaya , Günel Murat , Tüysüz Beyhan 
Published: February 2018

AbstractBackgroundThe camptodactyly–arthropathy–coxa vara–pericarditis syndrome (CACP) is a rare autosomal recessive condition characterized by camptodactyly, noninflammatory arthropathy, coxa vara, and pericarditis. CACP is caused by mutations in the proteoglycan 4 (PRG4) gene, which encodes a lubricating glycoprotein present in the synovial fluid and at the surface of articular cartilage.MethodsIn the present study, we compared the clinical and molecular findings of CACP syndrome in 35 patients from 11 unrelated families. In 28 patients, whole exome sequencing was used to investigate genomic variations.ResultsWe found that camptodactyly of hands was the first symptom presented by most patients. Swelling of wrists, knees, and elbows began before 4 years of age, while the age of joint involvement was variable. Patients reported an increased pain level after the age of 10, and severe hip involvement developed after 20 years old. All patients presented developmental coxa vara and seven patients (~22%) had pleural effusion, pericarditis, and/or ascites. We identified nine novel genomic alterations, including the first case of homozygous complete deletion of exon 1 in the PRG4 gene.ConclusionWith this study, we contribute to the catalog of CACP causing variants. We confirm that the skeletal component of this disease worsens with age, and presents the potential mechanisms for interfamily variability, by discussing the influence of a modifier gene and escape from nonsense‐mediated mRNA decay. We believe that this report will increase awareness of this familial arthropathic condition and the characteristic clinical and radiological findings will facilitate the differentiation from the common childhood rheumatic diseases such as juvenile idiopathic arthritis.
Patients’ experiences of the transcatheter aortic valve implantation trajectory: A grounded theory study
Authors: Olsson Karin , Näslund Ulf , Nilsson Johan , Hörnsten Åsa 
Published: February 2018

AbstractAimThe aim of this study was to explore how patients experienced the recovery process from transcatheter aortic valve implantation.DesignA qualitative approach where in‐depth interviews were used.MethodEleven men and eight women undergoing transcatheter aortic valve implantation were individually interviewed 6 months after transcatheter aortic valve implantation. Grounded theory was used for the analysis.ResultsThe analysis generated the core concept “A journey of balancing between life‐struggle and hope” connected to descriptive, bipolar categories. Before transcatheter aortic valve implantation patients not only felt threatened but also experienced hope. The rehabilitation phase was described as demanding or surprisingly simple. At the 6 months follow‐up patients were pleased to return to life, however, still struggling with limitations. To feel hope is essential for transcatheter aortic valve implantation patients’ well‐being, both before and during the recovery process. It is important that healthcare professionals not only support hopeful thinking but also take time to discuss and prepare patients, talk about concerns and build confidence. Individual plans for rehabilitation should be designed.
Using a new interrater reliability method to test the modified Oulu Patient Classification instrument in home health care
Authors: Flo Jill , Landmark Bjørg , Hatlevik Ove Edward , Fagerström Lisbeth 
Published: February 2018

AbstractAimTo test the interrater reliability of the modified Oulu Patient Classification instrument, using a multiple parallel classification method based on oral case presentations in home health care in Norway.DesignReliability study.MethodsData were collected at two municipal home healthcare units during 2013–2014. The reliability of the modified OPCq instrument was tested using a new multiple parallel classification method. The data material consisted of 2 010 parallel classifications, analysed using consensus in per cent and Cohen's kappa. Cronbach's alpha was used to measure internal consistency.ResultsFor parallel classifications, consensus varied between 64.78–77.61%. Interrater reliability varied between 0.49–0.69 (Cohen's kappa), the internal consistency between 0.81–0.94 (Cronbach's alpha). Analysis of the raw scores showed 27.2% classifications had the same points, 39.1% differed one point, 17.9% differed two points and 16.5% differed ≥3 points.
Nano‐Manufacturing Supramolecular Structures of Bio‐Inspired Naphthalene Diimide Bolaamphiphile via Solvophobic Controlled Self‐Assembly
Authors: Goskulwad Santosh P. , La Duong Duc , Bhosale Rajesh S. , Kobaisi Mohammad Al , Jones Lathe A , Bhosale Sidhanath V. , Bhosale Sheshanath V. 
Published: February 2018

AbstractWe report the synthesis of a naphthalene diimide bolaamphiphile (NDI‐1) bearing the peptide segment of Tyr‐Glu and studied self‐assembly through solvophobic control. NDI‐1 is shown to self‐assemble into a flower‐like morphology from its 4:6 THF/methylcyclohexane (MCH) (v/v) solution. Microscale broad grass‐like structures were obtained from NDI‐1 solution in 2:8 THF/H2O (v/v). The assembly formation was visualised by scanning electron microscope (SEM) imaging, furthermore, XRD used to determined mode of aggregation. This work demonstrates that complex self‐assembly can indeed be attained through hierarchical non‐covalent interactions of bio‐inspired naphthalene diimide‐peptide conjugates.
Atomic Layers of MoO2 with Exposed High‐Energy (010) Facets for Efficient Oxygen Reduction
Authors: Zhang Chao , Zou Xiaolong , Du Zhiguo , Gu Jianan , Li Songmei , Li Bin , Yang Shubin 
Published: February 2018

AbstractAlthough 2D nanocrystals with exposed high‐energy facets are highly desired in the field of catalysts due to their anticipant high catalytic activities, they are difficult to be gained. Here, atomic layers of metallic molybdenum dioxide (MoO2) with primarily exposed high‐energy (010) facet are achieved via a facile carbothermic reduction approach. The resultant MoO2 exhibits single‐crystalline, monoclinic, and ultrathin features with nearly 100% exposed (010) facet, which can significantly reduce reaction barriers toward the oxygen reduction reaction. As a consequence, the atomic layers of MoO2 exhibit high electrocatalytic activity, excellent tolerance to methanol, and good stability for the oxygen reduction reaction in alkaline electrolyte, superior to commercial Pt/C catalysts. It is believed that such new transition metal oxide catalysts with exposed high‐energy facets have broad applications in the areas of energy storage and conversions.
Parental effect of diapause in relation to photoperiod and temperature in the cabbage beetle, Colaphellus bowringi (Coleoptera: Chrysomelidae)
Authors: He H.-M. , Xiao H.-J. , Xue F.-S. 
Published: February 2018

AbstractIncreasing evidence has demonstrated that the environmental conditions experienced by parents can shape offspring phenotypes. Here, we examined the effects of the photoperiod and temperature experienced by parents on the incidence of diapause in their progeny in the cabbage beetle, Colaphellus bowringi, using three experiments. The first experiment examined parental diapause incidence under different photoperiods at 25°C and the incidence of diapause in progeny from both non-diapausing and diapausing parents under the same rearing conditions. The results revealed that the incidence of diapause among progeny was exactly opposite to that of their parents, i.e., higher parental diapause incidence led to lower progeny diapause incidence, showing a negative relationship in diapause incidence between the parental generation and the progeny generation. The incidence of diapause among progeny produced by diapausing parents was higher than that in progeny produced by non-diapausing parents. The second experiment examined parental diapause incidence at different temperatures under LD 12:12 and the incidence of diapause in progeny from both non-diapausing and diapausing parents under the same rearing conditions. Similarly, the incidence of diapause in progeny was also opposite to that of their parents. However, the incidence of diapause in progeny produced by non-diapausing parents was different from that in progeny produced by diapausing parents. In the third experiment, naturally diapausing adults were maintained at a constant temperature of 9, 28°C or the mean daily summer temperature of 27.84°C under continuous darkness for 3 months of dormancy. After dormancy, the progeny of these post-diapause parents were reared under different photoperiods at 25°C. The results showed that the incidence of diapause among progeny was higher when their parents experienced high temperatures than when they experienced low temperatures. All results demonstrate that the photoperiod and temperature experienced by parents may significantly affect the diapause incidence among progeny.
A cross-sectional pilot study of compassion fatigue, burnout, and compassion satisfaction in pediatric palliative care providers in the United States
Authors: Kase Samuel M. , Waldman Elisha D. , Weintraub Andrea S. 
Published: February 2018

AbstractObjectiveCompassion fatigue (CF) is secondary traumatic distress experienced by providers from contact with patients' suffering. Burnout (BO) is job-related distress resulting from uncontrollable workplace factors that manifest in career dissatisfaction. Compassion satisfaction (CS) is emotional fulfillment derived from caring for others. The literature on BO in healthcare providers is extensive, whereas CF and CS have not been comprehensively studied. Because of ongoing exposure to patient and family distress, pediatric palliative care (PPC) providers may be at particular risk for CF. We conducted a cross-sectional pilot study of CF, BO, and CS among PPC providers across the United States.MethodThe Compassion Fatigue and Satisfaction Self-Test for Helpers and a questionnaire of professional and personal characteristics were distributed electronically and anonymously to PPC physicians and nurses. Logistic and linear regression models for CF, BO, and CS as a function of potential risk factors were constructed.ResultsThe survey response rate was 39%, primarily consisting of female, Caucasian providers. The prevalence of CF, BO, and CS was 18%, 12%, and 25%, respectively. Distress about a “clinical situation,” physical exhaustion, and personal loss were identified as significant determinants of CF. Distress about “coworkers,” emotional depletion, social isolation, and “recent involvement in a clinical situation in which life-prolonging activities were not introduced” were significant determinants of BO. Physical exhaustion, personal history of trauma, “recent involvement in a clinical situation in which life-prolonging activities were not introduced,” and not discussing distressing issues were significant predictors of lower CS scores.Significance of resultsCF and BO directly influence the well-being and professional performance of PPC providers. To provide effective compassionate care to patients, PPC providers must be attentive to predictors of these phenomena. Further work is needed to explore additional causes of CF, BO, and CS in PPC providers as well as potential interventions.
A secondary RET mutation in the activation loop conferring resistance to vandetanib
Authors: Nakaoku Takashi , Kohno Takashi , Araki Mitsugu , Niho Seiji , Chauhan Rakhee , Knowles Phillip P. , Tsuchihara Katsuya , Matsumoto Shingo , Shimada Yoko , Mimaki Sachiyo , Ishii Genichiro , Ichikawa Hitoshi , Nagatoishi Satoru , Tsumoto Kouhei , Okuno Yasushi , Yoh Kiyotaka , McDonald Neil Q. , Goto Koichi 
Published: February 2018

AbstractResistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic lung adenocarcinoma harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant tumor acquired a secondary mutation resulting in a serine-to-phenylalanine substitution at codon 904 in the activation loop of the RET kinase domain. The S904F mutation confers resistance to vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase. A reduced interaction with the drug is also observed in vitro for the S904F mutant by thermal shift assay. A crystal structure of the S904F mutant reveals a small hydrophobic core around F904 likely to enhance basal kinase activity by stabilizing an active conformer. Our findings indicate that missense mutations in the activation loop of the kinase domain are able to increase kinase activity and confer drug resistance through allosteric effects.
Electrochemical reactor based on a polymer electrolyte fuel cell for the reduction reaction of CO2
Authors: Sone Yoshitsugu , Sato Kazutaka , Mendoza-Hernandez Omar Samuel , Shironita Sayoko , Shima Asuka , Umeda Minoru 
Published: February 2018

The Japan Aerospace Exploration Agency is now developing life support systems for closed environments in space. The reduction reaction of carbon dioxide is an important technique for the sustainable manned operation in space. Recently, Umeda et al. [J. Appl. Phys. 114, 174908 (2013)] from the Nagaoka University of Technology reported that the reduction reaction of carbon dioxide (CO2) proceeded using a fuel cell under the existence of CO2 and H2 by supplying those gases to the cathode and the anode, respectively. We observed stable reaction when Pt/Ru-C was used as a catalyst for the cathode and Pt-C for the anode. Different organic materials were obtained depending on the alternated potential and temperature. Furthermore, a fuel cell stack with 8 cells connected in series was tested to demonstrate the stable energy generation by feeding CO2 to the cathode and H2 to the anode.
Local Spectral Gap in the Group of Euclidean Isometries
Authors: Boutonnet Rémi , Ioana Adrian 
Published: February 2018

AbstractWe provide new examples of translation actions on locally compact groups with the “local spectral gap property” introduced in [5]. This property has applications to strong ergodicity, the Banach–Ruziewicz problem, orbit equivalence rigidity, and equidecomposable sets. The main group of study here is the group $\operatorname{Isom}\left (\mathbb{R}^{d}\right )$ of orientation-preserving isometries of the Euclidean space $\mathbb{R}^{d}$, for d ≥ 3. We prove that the translation action of a countable dense subgroup Γ on Isom$\left (\mathbb R^{d}\right )$ has local spectral gap, whenever the translation action of the rotation projection of Γ on SO(d) has spectral gap. Our proof relies on the amenability of $\operatorname{Isom}\left (\mathbb{R}^{d}\right )$ and on work of Lindenstrauss and Varjú [12].
Survival in elderly glioblastoma patients treated with bevacizumab-based regimens in the United States
Authors: Davies Jessica , Reyes-Rivera Irmarie , Pattipaka Thirupathi , Skirboll Stephen , Ugiliweneza Beatrice , Woo Shiao , Boakye Maxwell , Abrey Lauren , Garcia Josep , Burton Eric 
Published: February 2018

AbstractBackgroundThe efficacy of bevacizumab (BEV) in elderly patients with glioblastoma remains unclear. We evaluated the effect of BEV on survival in this patient population using the Survival, Epidemiology, and End Results (SEER)-Medicare database.MethodsThis retrospective, cohort study analyzed SEER-Medicare data for patients (aged ≥66 years) diagnosed with glioblastoma from 2006 to 2011. Two cohorts were constructed: one comprised patients who had received BEV (BEV cohort); the other comprised patients who had received any anticancer treatment other than BEV (NBEV cohort). The primary analysis used a multivariate Cox proportional hazards model to compare overall survival in the BEV and NBEV cohorts with initiation of BEV as a time-dependent variable, adjusting for potential confounders (age, gender, Charlson comorbidity index, region, race, radiotherapy after initial surgery, and diagnosis of coronary artery disease). Sensitivity analyses were conducted using landmark survival, propensity score modeling, and the impact of poor Karnofsky Performance Status.ResultsWe identified 2603 patients (BEV, n = 597; NBEV, n = 2006). In the BEV cohort, most patients were Caucasian males and were younger with fewer comorbidities and more initial resections. In the primary analysis, the BEV cohort showed a lower risk of death compared with the NBEV cohort (hazard ratio, 0.80; 95% confidence interval, 0.72–0.89; P < .01). The survival benefit of BEV appeared independent of the number of temozolomide cycles or frontline treatment with radiotherapy and temozolomide.ConclusionBEV exposure was associated with a lower risk of death, providing evidence that there might be a potential benefit of BEV in elderly patients with glioblastoma.
Improving Management of Hospitalized Adults With Uncomplicated Cellulitis or Cutaneous Abscess
Authors: Housman Erica , Livings Sarah E. , Knee Alex , Schimmel Jennifer 
Published: February 2018

Abstract
Implementation of a guideline for the management of hospitalized adults with uncomplicated skin and soft-tissue infections may decrease unnecessary antibiotic use. For cellulitis, treatment with vancomycin and broad-spectrum antibiotics decreased significantly. For cutaneous abscess, treatment with broad-spectrum antibiotics decreased significantly. There were no differences in rates of treatment failure, recurrence, or adverse events.
Combined NMDA Inhibitor Use in a Patient With Multisubstance-induced Psychotic Disorder
Authors: Caloro Matteo , Calabrò Giuseppa , de Pisa Eleonora , Rosini Enrico , Kotzalidis Georgios D. , Lonati Davide , Locatelli Carlo Alessandro , Papa Pietro , Schifano Fabrizio , Girardi Paolo 
Published: February 2018

Novel psychoactive substance use is a major social concern. Their use may elicit or uncover unpredictably as yet undescribed clinical pictures. We aimed to illustrate a multisubstance use case indistinguishable from paranoid schizophrenia, so to alert clinicians on possibly misdiagnosing substance-induced psychotic disorders.

Case report:
We describe a case of a 32-year-old man who started at 18 years with cannabinoids and ketamine, and is currently using N-methyl-d-aspartate (NMDA) antagonists. At age 23, he developed social withdrawal after being assaulted by a stranger, but did not consult psychiatrists until age 26; during this period, he was using internet-purchased methoxetamine and ketamine, and was persecutory, irritable, suspicious, and insomniac and discontinued all received medical prescriptions. He added dextromethorphan to his list of used substances. At age 31, while using phencyclidine, and, for the first time, methoxphenidine, he developed a religious delusion, involving God calling him to reach Him, and the near-death experiences ensured by NMDA antagonists backed his purpose. He received Diagnostic and Statistical Manual of Mental Disorders, 5th Edition diagnosis of multisubstance-induced psychotic disorder and was hospitalized 8 times, 6 of which after visiting the emergency room due to the development of extreme anguish, verbal and physical aggression, and paranoia. He reportedly used methoxphenidine, methoxyphencyclidine, ethylnorketamine, norketamine, and deschlorketamine, to achieve near-death experiences, and eventually to reach God in heavens.

Conclusions:
This case points to the need for better control of drugs sold on the internet. It also illustrates that people using NMDA antagonists may present clinical pictures indistinguishable from those of major psychoses and are likely to be misdiagnosed.
How does abatacept really work in rheumatoid arthritis?
Authors: Bonelli Michael , Scheinecker Clemens 
Published: February 2018

Purpose of review
The purpose of this review is to summarize the current knowledge concerning the mechanisms of action of Abatacept in patients with rheumatoid arthritis.

Recent findings
Abatacept (CTLA-4Ig) represents a soluble, recombinant, fully humanized fusion protein, comprising the extracellular domain of CTLA-4 and the Fc portion of IgG1. Abatacept binds to the costimulatory molecules CD80 and CD86 on antigen-presenting cells (APC), thereby blocking interaction with CD28 on T cells. In humans, Abatacept treatment was shown to be effective in patients with various autoinflammatory diseases including rheumatoid arthritis. Although the prevention of T-cell activation by interfering with signaling via CD28 still represents the main mechanism of action Abatacept acts on additional cell populations including regulatory T cells (Treg), monocytes/macrophages, osteoclasts, and B cells.

Summary
Effects of Abatacept on other cell populations besides T cells have to be taken into account and might represent a valuable contribution to the therapeutic success.