bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Was So New about the New Story? Modernist Realism in the Hindi Nayī Kahānī
Authors: Mani Preetha 
Published: August 2019

AbstractThis essay examines the Hindi Nayī Kahānī, or New Story, Movement of the 1950s and 1960s, which was influential for the short stories, criticism, and literary history that its writers produced. Incorporating a view toward the larger “metaliterary” corpus in relation to which properly “literary” nayī kahānī texts were written, the essay shows how the movement inaugurated a modernist realism characterized by attention to genre, rhetoric, and style on one hand, and commitment to social reality on the other. Combining rhetorical strategies—such as shifting narrative voice, allegorical descriptions of landscape, and implicit reference to authorship and the condition of postcolonial literary production—with structural and thematic tensions between form and content, this mode developed an interchangeability between author, reader, and character, which did not previously exist in Hindi literature and which reconfigured the category of the middle class in the universally recognizable terms of alienation. Using the case of the nayī kahānī, the essay offers a new literary historical approach that moves beyond sweeping accounts of a single postcolonial mode to attend to regional realisms and modernisms.
Seuss and the Swerve of Singularity
Authors: Peterson Christopher 
Published: August 2019

AbstractThis article explores the unstable distinction between “who” and “what” in Seuss’s Horton Hears a Who! The story’s moral that “a person’s a person no matter how small” has often been read as atoning for the racist cartoons that Geisel drew of the Japanese during World War II. Seussian pedagogy teaches us to hear all persons as whos rather than whats or things. Yet this essay argues that all persons are also things. While this thingliness remains unequally distributed thanks to persistent sociopolitical hierarchies, it also calls on us to think about ethics and politics differently. Diverging from the person/who equation, Jacques Derrida conceives the who as an absolute singularity that resists its subjection to the what, and by extension, its reduction to particularity and identity. Expanding beyond Horton’s racial context, the final section of the essay considers how the contemporary “Black Lives Matter” movement reckons with the problem of particularity and identity while also gesturing toward an incalculable singularity—infinitely deferred yet always “present.”
Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal
Authors: Kim-Yip Rebecca P. , Nystul Todd G. 
Published: August 2019

ABSTRACT
Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the Drosophila ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. We found that Wingless produced by inner germarial sheath (IGS) cells acts over a short distance to activate Wnt signaling in FSCs, and that movement across the FSC niche boundary is limited. In addition, we show that Wnt signaling functions genetically upstream of EGFR signaling by activating the expression of the EGFR ligand, Spitz, and that constitutive activation of EGFR partially rescues the self-renewal defect caused by loss of Wnt signaling. Collectively, our findings support a model in which the Wnt and EGFR pathways operate in a signaling hierarchy to promote FSC self-renewal.
MEIS transcription factors in development and disease
Authors: Schulte Dorothea , Geerts Dirk 
Published: August 2019

ABSTRACT
MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.
Intramembrane proteolysis at a glance: from signalling to protein degradation
Authors: Kühnle Nathalie , Dederer Verena , Lemberg Marius K. 
Published: August 2019

ABSTRACT
Over the last two decades, a group of unusual proteases, so-called intramembrane proteases, have become increasingly recognized for their unique ability to cleave peptide bonds within cellular membranes. They are found in all kingdoms of life and fulfil versatile functions ranging from protein maturation, to activation of signalling molecules, to protein degradation. In this Cell Science at a Glance article and the accompanying poster, we focus on intramembrane proteases in mammalian cells. By comparing intramembrane proteases in different cellular organelles, we set out to review their functions within the context of the roles of individual cellular compartments. Additionally, we exemplify their mode of action in relation to known substrates by distinguishing cleavage events that promote degradation of substrate from those that release active domains from the membrane bilayer.
Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0
Authors: Mosesso Niccolò , Nagel Marie-Kristin , Isono Erika 
Published: August 2019

ABSTRACT
The ability to sense and adapt to the constantly changing environment is important for all organisms. Cell surface receptors and transporters are key for the fast response to extracellular stimuli and, thus, their abundance on the plasma membrane has to be strictly controlled. Heteromeric endosomal sorting complexes required for transport (ESCRTs) are responsible for mediating the post-translational degradation of endocytosed plasma membrane proteins in eukaryotes and are essential both in animals and plants. ESCRTs bind and sort ubiquitylated cargoes for vacuolar degradation. Although many components that comprise the multi-subunit ESCRT-0, ESCRT-I, ESCRT-II and ESCRT-III complexes are conserved in eukaryotes, plant and animal ESCRTs have diverged during the course of evolution. Homologues of ESCRT-0, which recognises ubiquitylated cargo, have emerged in metazoan and fungi but are not found in plants. Instead, the Arabidopsis genome encodes plant-specific ubiquitin adaptors and a greater number of target of Myb protein 1 (TOM1) homologues than in mammals. In this Review, we summarise and discuss recent findings on ubiquitin-binding proteins in Arabidopsis that could have equivalent functions to ESCRT-0. We further hypothesise that SH3 domain-containing proteins might serve as membrane curvature-sensing endophilin and amphiphysin homologues during plant endocytosis.
A Mobile Application for Exercise Intervention in People Living with HIV
Authors: BONATO MATTEO , TURRINI FILIPPO , DE ZAN VALENTINA , MELONI ANDREA , PLEBANI MARTA , BRAMBILLA ELENA , GIORDANI ALESSANDRA , VITOBELLO CHIARA , CACCIA ROBERTA , PIACENTINI MARIA FRANCESCA , LA TORRE ANTONIO , LAZZARIN ADRIANO , MERATI GIAMPIERO , GALLI LAURA , CINQUE PAOLA 
Published: August 2019

ABSTRACT

Purpose
This study aimed to assess 16-wk improvements of physical fitness, metabolic, and psychological parameters in people living with HIV (PLWH) exercising with the support of a smartphone application, as compared with a control group exercising without application.

Methods
This was a randomized, open-label, pilot study enrolling PLWH in a 16-wk protocol consisting of moderate physical activity three times per week, which included an initial coach-supervised period of 4 wk, followed by 12 wk where participants trained independently. Participants were allocated to either an experimental group that trained using a smartphone application (APP) or a control group that practiced following a hard copy training program (No-APP). At baseline (BL) and after 16 wk (W16), patients were assessed for cardiorespiratory fitness, body composition, blood lipid profile, and POMS.

Results
Forty-eight PLWH were screened and 38 were eligible: 20 were allocated to the APP group and 18 to the No-APP group. Two APP and two No-APP participants were lost to follow-up. Intention-to-treat analysis showed a W16 improvement from BL of ≥15% V˙ O2peak in 13 (72%) of 18 in APP, but only in 3 (19%) of 16 in No-APP participants (P = 0.025). Significant W16 improvements were observed in APP, but not in No-APP participants, in V˙O2peak; fat mass and fat-free mass percent; total cholesterol, LDL cholesterol, and triglycerides; vigor; and total mood by POMS. Accordingly, significant percent change differences between the APP and the No-APP groups were observed in V˙O2peak; fat and fat-free mass percent; total cholesterol, LDL cholesterol, and triglycerides; and depression, vigor, anger, and total mood by POMS.

Conclusions
Exercising using a smartphone application improved cardiorespiratory fitness, body composition, cholesterol profiles, and psychological outcomes in PLWH.
Study protocol for a randomised controlled trial of haloperidol plus promethazine plus chlorpromazine versus haloperidol plus promethazine for rapid tranquilisation for agitated psychiatric patients in the emergency setting (TREC-Lebanon)
Authors: Dib Joseph E. , Adams Clive E. , Ikdais Werner Henry , Atallah Elie , Yaacoub Hiba Edward , Merheb Tony Jean , Kazour Francois , Tahan Fouad , Haddad Georges , Zoghbi Marouan , Azar Jocelyn , Haddad Chadia , Hallit Souheil 
Published: August 2019

Background: Agitated and aggressive behaviours are common in the psychiatric setting and rapid tranquilisation is sometimes unavoidable. A survey of Lebanese practice has shown that an intramuscular haloperidol, promethazine and chlorpromazine combination is a preferred form of treatment but there are no randomised trials of this triple therapy. Methods: This is a pragmatic randomised trial. Setting - the psychiatric wards of the Psychiatric Hospital of the Cross, Jal Eddib, Lebanon. Participants - any adult patient in the hospital who displays an aggressive episode for whom rapid tranquilisation is unavoidable, who has not been randomised before, for whom there are no known contraindications. Randomisation – stratified (by ward) randomisation and concealed in closed opaque envelope by independent parties. Procedure – if the clinical situation arises requiring rapid tranquilisation, medical residents overseeing the patient will open a TREC-Lebanon envelope in which will be notification of which group of treatments should be preferred [Haloperidol + Promethazine + Chlorpromazine (HPC) or Haloperidol + Promethazine (HP)], along with forms for primary, secondary and serious adverse effects. Treatment is not given blindly. Outcome - primary outcome is calm or tranquil at 20 minutes post intervention. Secondary outcomes are calm/tranquil at 40, 60 and 120 minutes post intervention, asleep, adverse effects, use of straitjacket and leaving the ward. Follow-up will be up to two weeks post randomisation. Discussion: Findings from this study will compare the HPC versus HP combination used in Lebanon’s psychiatry emergency routine practice. Trial registration: ClinicalTrials.gov NCT03639558. Registration date, August 21, 2018.
Transhiatal Herniation as the Cause of Acute Pancreatitis After Toupet Fundoplication
Authors: Zackria Rasiq , Popa Alina 
Published: August 2019

ABSTRACT
Hiatal translocation of the pancreas is rare because of its retroperitoneal location. Acute pancreatitis as a complication of hiatal hernia is uncommon. A 33-year-old man presented for 2 days of worsening epigastric abdominal pain and substernal chest pain. Laboratory studies were essentially unremarkable; however, computed tomography demonstrated a large right-sided hiatal hernia containing the entire stomach and the body of the pancreas, with peripancreatic edema consistent with pancreatitis. Most cases can be managed conservatively; however, elective surgical repair is suggested in severe cases or patients with low surgical risk.
Liquid biopsy of cerebrospinal fluid identifies neuronal pentraxin receptor (NPTXR) as a biomarker of progression of Alzheimer’s disease
Authors: Lim Bryant , Tsolaki Magda , Soosaipillai Antoninus , Brown Marshall , Zilakaki Maria , Tagaraki Fani , Fotiou Dimitrios , Koutsouraki Effrosyni , Grosi Effrosyni , Prassas Ioannis , Diamandis Eleftherios P. 
Published: August 2019

Abstract

Background
Alzheimer’s disease (AD) is the most prevalent form of dementia. Currently, the most studied biomarkers of AD are cerebrospinal fluid (CSF) amyloid β 1-42, total tau and phosphorylated tau. However, misdiagnosis can exceed 20%. Recently, we found that CSF amyloid β precursor-like protein-1 (APLP1) and neuronal pentraxin receptor (NPTXR) are promising biomarkers of AD. The aim of the present study is to validate CSF APLP1 and NPTXR as biomarkers of AD severity.

Methods
APLP1 and NPTXR concentrations were measured in the CSF of patients with mild cognitive impairment (MCI) (n = 14), mild AD (n = 21), moderate AD (n = 43) and severe AD (n = 30) using enzyme-linked immunosorbent assays (ELISAs).

Results
CSF APLP1 and NPTXR were not associated with age or sex. CSF APLP1 was not different between any of the AD severity groups (p = 0.31). CSF NPTXR was significantly different between MCI and mild AD (p = 0.006), mild and moderate AD (p = 0.016), but not between moderate and severe AD (p = 0.36). NPTXR concentration progressively declined from MCI to mild, to moderate and to severe AD patients (p < 0.0001, Kruskal-Wallis test). CSF NPTXR positively correlated with the Mini-Mental Status Examination (MMSE) score (p < 0.001).

Conclusions
NPTXR concentration in CSF is a promising biomarker of AD severity and could inform treatment success and disease progression in clinical settings.
Babylon Berlin: Pastiching Weimar cinema
Authors: Hall Sara F. 
Published: August 2019

AbstractCentered on Richard Dyer’s model of pastiche, this essay posits that the German television series Babylon Berlin engages in a unique and timely practice of cultural reproduction shaped by a specific combination of historical subject matter and the present media-historical moment. Through digital effects, narrational layering, and multivalent location choices, Babylon Berlin pastiches Weimar cinema, and self-consciously invites comparisons between the so-called golden age of German cinema and the present. It activates cinephilic recall, establishes an intermedial dialogue between analog and digital forms, and affectively engenders a historically oriented conversation about the fragility of modern democracy in the Brexit/Trump era. The cultural work of pastiche it performs warrants the series’ inclusion in the conversation around the European remake.
A new classification scheme for teaching reaction types in general chemistry
Authors: Wang Bin 
Published: August 2019

Abstract
General chemistry is a freshman-level class required for most science majors and pre-professional undergraduates. A variety of concepts are introduced in this course; among them, chemical reactions are fundamental, but remain a central topic. The author compared 10 textbooks widely used for college-level general chemistry courses. They all cover the three major classes of chemical reactions: precipitation reactions, acid-base reactions, and oxidation-reduction (redox) reactions. However, significant differences in the way these textbooks present the material may cause confusion and misunderstanding for students, including when they move to upper-level courses. The author suggests a modified reaction classification scheme for general chemistry courses, which will provide students a more complete and nuanced understanding of chemical reactions.
Company Law, Connecting Factors and the Digital Age – A New Outlook
Authors: Kurcz Bartlomiej , Paizis Athanasios 
Published: August 2019

Usually connecting factors in company law play a decisive role with regard to the corporate governance model of a company and with regard to the level of protection of stakeholders. Their importance generated a long-lasting debate on which connecting factor is “better” and which one is compatible with internal market rules. However, technological developments and digitalisation shed a different light on this discussion.
In order to understand how the current developments impact the discussion on company law connecting factors, it should first be clear what is really understood by connecting factors in the jurisprudence of the Court of Justice. It is important to understand the relationship between substantive company law rules and those on conflict of laws.
The outcome of the above analysis allows to add the digitalisation/new technologies factor into the equation. In this context, a closer look is given at the use of artificial intelligence applications in company law and the operation of a decentralised autonomous organisation within a blockchain network. It allows to question the effectiveness and usefulness of traditional connecting factors.
Assessment of Genetic Diversity of Cultivated Sunflower in Terms of Oil Content, Fatty Acid Compositions and Seed Traits
Authors: Ahmadian Soolmaz , Tahmasebi Enferadi Sattar , Alemzadeh Abbas 
Published: August 2019

Abstract
Sunflower (Helianthus annuus L.) cultivated accessions contains useful genes encoding different phenotypic characteristic through which the origin of sunflower oil could be hypothesized. Those genes could be later used for future breeding programs for providing better quality sunflower oil.
The objective of the current study is to discriminate genetic diversity of cultivated sunflower seeds collection through the statistical methods such as PCA (principal component analysis) and Pearson correlation analysis for two characters; seed oil content and fatty acid composition.
Materials and methods: In the present study, the genetic diversity of 107 cultivated accessions of Helianthus annuus L. was studied for fatty acid composition and oil content. Pearson correlation and Principal Component Analysis (PCA) were used to determine the correlation between the studied parameters. A dendrogram using Ward’s method and the squared Euclidean distance coefficient was produced.
The results showed that the average seed oil content in the accessions was 29.51 % with a profile of 7.23 % palmitic acid (PAL), 5.04 % stearic acid (STE), 36.85 % oleic acid (OLE) and 50.85 % linoleic acid (LIN). The highest oil content was found in accession Hopi Dye (43.66 %). High levels of OLE were observed in the Csehszlovakiai “B” (60.14 %) and Vk-47 (55.73 %) accessions. On the other hand, Fuksinka 10 and Georgia accessions had the lowest mean PAL values (4.98 %) and STE (1.81 %), respectively. Palmitoleic acid (PALM) was identified in 29 accessions and linolenic acid (LIL) in 32 accessions, the highest in Gonondu (0.86 %) and Oleisty Borovskil (0.76 %), respectively. A significant negative relationship between OLE, STE and saturated fatty acids (SFA) with oil content was observed. The Pearson correlation of unsaturated fatty acids to saturated fatty acids ratio (UFA/SFA ratio) with oil content was positive and significant. In the PCA analysis, four major principal components (PCs) were identified, accounting for 87.19 % of the total variations. In PC1, PAL and STE (with positive coefficients) and UFA/SFA ratio (with negative coefficients), had the highest loadings, which determined 41.33 % of the total variations. In PC 2, OLE (with negative coefficient) and LIN (with positive coefficient), had the highest values. According to the dendrogram of the accessions, they were grouped into seven distinct clusters and the accessions in clusters 4 and 7 contained high UFA and low SFA values.
The findings of this study showed that there is a significant genetic diversity among the accessions, which can be used to maximize heterosis in sunflower breeding programs.
Genetic Resources of the Sunflower Crop Wild Relatives for Resistance to Sunflower Broomrape
Authors: Seiler Gerald J. 
Published: August 2019

Abstract
One of the most threatening holoparasitic plant species is Orobanche cumana Wallr. (sunflower broomrape), mainly distributed in the Mediterranean region and Western Asia where it exclusively parasitizes sunflowers. Sunflower broomrape (BR) is a very destructive parasitic weed causing significant yield losses under high infestations that can easily spread and is vulnerable to mutations. Broomrape is highly variable, controlled by vertical single dominant resistance genes leading to the rapid and frequent breakdown of resistance. This subsequently leads to the continuing need for new unique genes from multiple sources for controlling new emerging virulent races. The USDA-ARS, National Plant Germplasm System crop wild relatives (CWR) collection contains 2,519 accessions of 53 species with 14 annual species (1641 accessions) and 39 perennial species (878 accessions). This CWR collection provides a vast genetic resource for new BR resistance genes, especially in Europe and the Middle East. Sunflower CWR evaluations for new resistance genes for BR races have demonstrated that they are a substantial reservoir for existing and new emerging virulent races. Resistance to sunflower broomrape, including immunity, has been reported in seven annual and 32 perennial species. These sources discovered in the sunflower CWR confer resistance to new virulent broomrape races F, G, and H, and others that have not been assigned a race designation. Since several of the resistant CWR sources are annual and have the same chromosome number as cultivated sunflower, broomrape resistance genes can be incorporated into hybrid sunflower through interspecific hybridization. The diverse sources of resistance from the CWR provide breeders with the prospect for durable broomrape control through exploiting genetic resistance for existing and newly emerging races.
Polarity Analysis of Customer Reviews Based on Part-of-Speech Subcategory
Authors: Ghabayen Ayman S. , Ahmed Basem H. 
Published: August 2019

Abstract
Nowadays, sentiment analysis is a method used to analyze the sentiment of the feedback given by a user in an online document, such as a blog, comment, and review, and classifies it as negative, positive, or neutral. The classification process relies upon the analysis of the polarity features of the natural language text given by users. Polarity analysis has been an important subtask in sentiment analysis; however, detecting correct polarity has been a major issue. Different researchers have utilized different polarity features, such as standard part-of-speech (POS) tags such as adjectives, adverbs, verbs, and nouns. However, there seems to be a lack of research focusing on the subcategories of these tags. The aim of this research was to propose a method that better recognizes the polarity of natural language text by utilizing different polarity features using the standard POS category and the subcategory combinations in order to explore the specific polarity of text. Several experiments were conducted to examine and compare the efficacies of the proposed method in terms of F-measure, recall, and precision using an Amazon dataset. The results showed that JJ + NN + VB + RB + VBP + RP, which is a POS subcategory combination, obtained better accuracy compared to the baseline approaches by 4.4% in terms of F-measure.