bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort
Authors: Cramer Daniel W. , Fichorova Raina N. , Terry Kathryn L. , Yamamoto Hidemi , Vitonis Allison F. , Ardanaz Eva , Aune Dagfinn , Boeing Heiner , Brändstedt Jenny , Boutron-Ruault Marie-Christine , Chirlaque Maria-Dolores , Dorronsoro Miren , Dossus Laure , Duell Eric J. , Gram Inger T. , Gunter Marc , Hansen Louise , Idahl Annika , Johnson Theron , Khaw Kay-Tee , Krogh Vittorio , Kvaskoff Marina , Mattiello Amalia , Matullo Giuseppe , Merritt Melissa A. , Nodin Björn , Orfanos Philippos , Onland-Moret N. Charlotte , Palli Domenico , Peppa Eleni , Quirós J. Ramón , Sánchez-Perez Maria-Jose , Severi Gianluca , Tjønneland Anne , Travis Ruth C. , Trichopoulou Antonia , Tumino Rosario , Weiderpass Elisabete , Fortner Renée T. , Kaaks Rudolf 
Published: April 2018

Abstract
Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined.
Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression.
Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both.
Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types.
Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC. Cancer Epidemiol Biomarkers Prev; 27(7); 790–804. ©2018 AACR.
Immunogenomic Analyses of Advanced Serous Ovarian Cancer Reveal Immune Score is a Strong Prognostic Factor and an Indicator of Chemosensitivity
Authors: Hao Dapeng , Liu Jie , Chen Meng , Li JingJing , Wang Li , Li Xiaobo , Zhao Qi , Di Li-jun 
Published: April 2018

AbstractPurpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important for the clinical outcome. To elucidate the mechanistic relationship between immune repertoire and cancer genotype in ovarian cancer, the development of a well-defined immune score for ovarian cancer is required.Experimental Design: From a collection of 2,203 patient samples of advanced ovarian cancer from public available resources, we evaluated the prognostic values for a compendium of immune marker genes and proposed an immune score. The relationships between immune score, tumor-infiltrating immune cells, cancer genotypes, and their impact on patient outcome were characterized.Results: Loss of chemokine and IFNγ pathway genes is frequent in ovarian cancer and is significantly associated with low immune score and poor outcome. Chemotherapy can increase the immune score of tumors by inducing the expression of IFNγ inducible chemokines. High immune score is significantly associated with BRCA1/2 mutation status and the response to chemotherapy. Multivariate analysis revealed that immune score is a strong predictor of patient survival and the response to immunotherapy.Conclusions: Our results reveal the drivers of the immune repertoire of advanced ovarian cancer and demonstrate the importance of immune score as an independent prognostic signature and a potent indicator of intratumoral immune status. Clin Cancer Res; 24(15); 3560–71. ©2018 AACR.
Cigarette Smoking and Incident Heart Failure
Authors: Kamimura Daisuke , Cain Loretta R. , Mentz Robert J. , White Wendy B. , Blaha Michael J. , DeFilippis Andrew P. , Fox Ervin R. , Rodriguez Carlos J. , Keith Rachel J. , Benjamin Emelia J. , Butler Javed , Bhatnagar Aruni , Robertson Rose M. , Winniford Michael D. , Correa Adolfo , Hall Michael E. 
Published: April 2018

Background:
Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization.

Methods:
We investigated 4129 (never smoker n=2884, current smoker n=503, and former smoker n=742) black participants (mean age, 54 years; 63% women) without a history of HF or coronary heart disease at baseline in the Jackson Heart Study. We examined the relationships between cigarette smoking and LV structure and function by using cardiac magnetic resonance imaging among 1092 participants, cigarette smoking and brain natriuretic peptide levels among 3325 participants, and incident HF hospitalization among 3633 participants with complete data.

Results:

After adjustment for confounding factors, current smoking was associated with higher mean LV mass index and lower mean LV circumferential strain (
P
<0.05, for both) in comparison with never smoking. Smoking status, intensity, and burden were associated with higher mean brain natriuretic peptide levels (all
P
<0.05). Over 8.0 years (7.7–8.0) median follow-up, there were 147 incident HF hospitalizations. After adjustment for traditional risk factors and incident coronary heart disease, current smoking (hazard ratio, 2.82; 95% confidence interval, 1.71–4.64), smoking intensity among current smokers (≥20 cigarettes/d: hazard ratio, 3.48; 95% confidence interval, 1.65–7.32), and smoking burden among ever smokers (≥15 pack-years: hazard ratio, 2.06; 95% confidence interval, 1.29–3.3) were significantly associated with incident HF hospitalization in comparison with never smoking.

Conclusions:
In blacks, cigarette smoking is an important risk factor for LV hypertrophy, systolic dysfunction, and incident HF hospitalization even after adjusting for effects on coronary heart disease.
Rethinking Knowledge and Difference in Latin America’s Insurgent Moment: On de Sousa Santos and García Linera
Authors: Cavooris Robert 
Published: April 2018

AbstractThis review examines two works that address the theoretical importance of Latin American political movements over the last two decades. I argue that while Boaventura de Sousa Santos raises the important issue of the political relationship between difference and unity, his work lends itself to ambiguous conclusions regarding this relationship. In particular, de Sousa Santos underestimates Marxism’s potential role as a theory and practice of political union. Nonetheless, his work provides certain insights on epistemology and political temporality that may help Marxism amplify its political relevance today. Álvaro García Linera’s text represents a particular mode by which Marxism may engage with a politics of difference; however, I argue that García Linera’s work contains a tension between difference construed in autonomist, material terms and difference construed as identity. The latter, I suggest, has come to serve in Bolivia as the basis for an ultimately limited political project.
Atimia and Outlawry in Archaic and Classical Greece
Authors: Joyce Christopher 
Published: April 2018

Abstract
This article challenges the commonly held belief that atimia in its earliest Greek usage meant exile, arguing instead that atimia and outlawry were always two entirely distinct, though not mutually exclusive, concepts. It is often claimed that atimia originated as a penalty of death or exile, but that over time its harshness became modified so that those who suffered under its restrictions could not be killed or assaulted with impunity. A careful study of the evidence will show that atimia never meant outlawry, and moreover, its archaic cognates do not imply that in early times to lose timê was the same as losing membership in a political community. Rather, atimazesthai entailed the loss of social honour and status which was an all-encompassing value in the aristocratic societies of archaic Greece. Atimia in the Classical period is similarly a loss of rights (timai), and because penalties and conditions such as exile and outlawry can be easily described, in Greek, as involving the loss of prerogatives (timai), they are conceptually forms of atimia. However, in the legal language of democratic Athens atimia is and always was something distinct from exile, and this legal distinction went back to the very earliest times.
Wicked Angels and the Good Demon: The Origins of Alchemy According to the Physica of Hermes
Authors: Bull Christian H. 
Published: April 2018

AbstractThe alchemist Zosimus of Panopolis, writing around 300ce, is our only source for a series of treatises by Hermes called the Physica, which reportedly spoke about angels who had intercourse with women, as in 1 Enoch, and which credited the revelation of alchemy to an enigmatic figure called Chemeu. The present contribution aims to show that Zosimus has in fact harmonized the account of 1 Enoch with the Physica of Hermes, identifying the Watchers of the former treatise with wicked angels who perverted the authentic art of alchemy, originally revealed to Hermes by Chemeu, who should be identified with Agathodaimon. It is further argued that the Physica likely served as a source for the Hermetic treatises the Perfect Discourse (Ascl. =nhcvi,8) and Kore Kosmou (Stob. herm. 23). This indicates that the literary relationship between the technical and theoretical Hermetica is tighter than hitherto assumed.
The Notion of Truth in Some Hermetic Texts and Chaldaean Oracles
Authors: van den Kerchove Anna 
Published: April 2018

AbstractThe following paper is an inquiry into the notion of truth in the Hermetic fragment Stobaeus Hermetica 2aand the Chaldaean Oracles fr. 107. In both texts, the truth has an absolute status and is considered not to be present on earth. This conception has consequences for the way of evaluating sciences, divination, philosophy and ritual. In order to study how these four topics are portrayed, the article analyzes other Hermetic passages, in particular that can be found in the Asclepius. The four topics are positively evaluated only when they are related to the “primary truth.” Philosophy encompasses the four topics and is defined as piety. This impacts the attitude that the Hermetic groups might adoptvis-à-visthe civic sacrifices, especially when the Decian edict obliged the citizens to sacrifice.
A Method for Identifying Midlatitude Mesoscale Convective Systems in Radar Mosaics. Part I: Segmentation and Classification
Authors: Haberlie Alex M. , Ashley Walker S. 
Published: April 2018

AbstractThis research evaluates the ability of image-processing and select machine-learning algorithms to identify midlatitude mesoscale convective systems (MCSs) in radar-reflectivity images for the conterminous United States. The process used in this study is composed of two parts: segmentation and classification. Segmentation is performed by identifying contiguous or semicontiguous regions of deep, moist convection that are organized on a horizontal scale of at least 100 km. The second part, classification, is performed by first compiling a database of thousands of precipitation clusters and then subjectively assigning each sample one of the following labels: 1) midlatitude MCS, 2) unorganized convective cluster, 3) tropical system, 4) synoptic system, or 5) ground clutter and/or noise. The attributes of each sample, along with their assigned label, are used to train three machine-learning algorithms: random forest, gradient boosting, and “XGBoost.” Results using a testing dataset suggest that the algorithms can distinguish between MCS and non-MCS samples with a high probability of detection and low probability of false detection. Further, the trained algorithm predictions are well calibrated, allowing reliable probabilistic classification. The utility of this two-step procedure is illustrated by generating spatial frequency maps of automatically identified precipitation clusters that are stratified by using various reflectivity and probabilistic prediction thresholds. These results suggest that machine learning can add value by limiting the amount of false-positive (non-MCS) samples that are not removed by segmentation alone.
A Method for Identifying Midlatitude Mesoscale Convective Systems in Radar Mosaics. Part II: Tracking
Authors: Haberlie Alex M. , Ashley Walker S. 
Published: April 2018

AbstractThis research is Part II of a two-part study that evaluates the ability of image-processing and select machine-learning algorithms to detect, classify, and track midlatitude mesoscale convective systems (MCSs) in radar-reflectivity images for the conterminous United States. This paper focuses on the tracking portion of this framework. Tracking is completed through a two-step process using slice (snapshots of instantaneous MCS intensity) data generated in Part I. The first step is to perform spatiotemporal matching, which associates slices through temporally adjacent radar-reflectivity images to generate swaths, or storm tracks. When multiple slices are found to be matches, a difference-minimization procedure is used to associate the most similar slice with the existing swath. Once this step is completed, a second step combines swaths that are spatiotemporally close. Tracking performance is assessed by calculating select metrics for all available swath-building perturbations to determine the optimal approach in tracking. Frequency maps and time series generated from the swaths suggest that the spatiotemporal occurrence of these swaths is reasonable as determined from previous work. Further, these events exhibit a diurnal cycle that is distinct from that of overall convection for the conterminous United States. Last, machine-learning predictions are found to limit areas of high MCS frequency to the central and eastern Great Plains.
Decadal Variability of the Meridional Geostrophic Transport in the Upper Tropical North Pacific Ocean
Authors: Zhou Hui , Yuan Dongliang , Yang Lina , Li Xiang , Dewar William 
Published: April 2018

AbstractThe meridional geostrophic transport (MGT) in the interior tropical North Pacific Ocean is estimated based on global ocean heat and salt content data. The decadal variations of the zonally and vertically integrated MGT in the tropical North Pacific Ocean are found to precede the Pacific decadal oscillation (PDO) by 1–3 years. The dynamics of the MGT are analyzed based on Sverdrup theory. It is found that the total meridional transport variability (MGT plus Ekman) is dominated by the MGT variability having positive correlations with the PDO index. The Sverdrup transports differ from the total meridional transport significantly and have insignificant correlations with PDO index, suggesting that the MGT variability is not controlled by the Sverdrup dynamics. In comparison, the simulated meridional transport variability in the models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) and the Ocean General Circulation Model for the Earth Simulator are dominated by the Sverdrup transports, having insignificant correlations with the simulated PDO indices. The comparison suggests that the non-Sverdrup component in the MGT is important for the predictability of PDO and that significant deficiencies exist in these models in simulating a realistic structure of the tropical ocean gyre variability and predicting the decadal climate variations associated with it.
Endobronchial stenting on VV-ECMO in a 6-month-old girl with right lung agenesis and severe stenosis of the left main bronchus
Authors: Vobruba Vaclav , Votruba Jiri , Bělohlávek Jan , Grus Tomas , Leden Pavel , Zaoral Tomas , Hřídel Jan 
Published: April 2018

Introduction: Lung agenesis is a rare disorder with a variable, but potentially very bad clinical course. It necessitates complex clinical management, especially in life-threatening situations. Case report: We describe a case of a 6-month-old girl with right lung agenesis who required venovenous extracorporeal membrane oxygenation (VV-ECMO) due to pneumonia complicated by exacerbated previously diagnosed left main bronchus stenosis. The stenosis was resolved by endobronchial intervention and X-ray-guided stent insertion, which enabled weaning from ECMO and was aimed at preventing such a life-threatening respiratory failure in the future. Unfortunately, even with the functional stent, the baby died 2 months post-procedure due to unresolvable bronchial spasms. Discussion: Despite high endobronchial stenting-related mortality in children, in cases where no effective pharmacological or surgical alternatives exist, stenting may be safely performed during VV-ECMO support and be a viable option to overcome critical respiratory failure caused by bronchial stenosis.
A Randomized Open-Label Parallel-Group Study Comparing Ondansetron with Ondansetron plus Dexamethasone in Patients with Metastatic Breast Cancer Receiving High-Dose Epirubicin. A Hellenic Cooperative Oncology Group Study
Authors: Janinis Jim , Giannakakis Theodore , Athanasiades Athanasios , Fountzilas George , Bafaloukos Dimitrios , Kosmidis Paris , Nikolaides Kostas , Pavlidis Nicholas , Skarlos Dimosthenis 
Published: April 2018

Aims and background The purpose of this multicenter randomized, open-label, parallel-group study was to assess whether the addition of low-dose dexamethasone to ondansetron results in improved control of chemotherapy-induced emesis in patients undergoing first-line chemotherapy with high-dose epirubicin. Methods & study design Patients were randomized to receive either 24 mg of ondansetron or 24 mg of ondansetron plus 8 mg of dexamethasone administered as an intravenous infusion 30 minutes prior to administration of chemotherapy. Both groups of patients received 8 mg of ondansetron given orally from day 2 to 5 two times daily. Fifty-three patients received ondansetron and 50 received ondansetron plus dexamethasone. The patients recorded nausea and the number of vomits and retches daily on diary cards. Results Significantly more patients in the ondansetron plus dexamethasone group experienced neither vomiting nor retching during the first day of the first course of chemotherapy compared to those receiving ondansetron alone (79.6% vs 53.8%, P = 0.0062). Furthermore, there was a trend in favor of ondansetron plus dexamethasone in the control of nausea. There was no statistically significant difference between ondansetron plus dexamethasone versus ondansetron alone in protecting patients from emesis between days 2 and 5 of the first course of chemotherapy (66.7% vs 62.7%, P = 0.68). This was probably due to the small sample size. Ondansetron was well tolerated, with 15 patients (15%) reporting adverse events such as headache or constipation. Conclusions It appears that ondansetron given intravenously in combination with dexamethasone is more effective than ondansetron alone in the control of acute emesis in patients undergoing their first course of chemotherapy with high-dose epirubicin. No difference between the regimens was found with regard to nausea and delayed emesis control.
Tumor Infiltrating Lymphocytes and Continuous Infusion Interleukin-2 after Metastasectomy in 61 Patients with Melanoma, Colorectal and Renal Carcinoma
Authors: Fabbri Muller , Ridolfi Ruggero , Maltoni Roberta , Ridolfi Laura , Riccobon Angela , Flamini Emanuela , De Paola Franca , Verdecchia Giorgio Maria , Amadori Dino 
Published: April 2018

Aims and background Adoptive immunotherapy with tumor infiltrating lymphocyte (TIL) reinfusion plus continuous interleukin-2 (IL-2) infusion could represent an innovative way of treating immunogenic tumors. This study therefore recruited melanoma, colorectal and renal carcinoma patients whose metastases had been surgically removed. Study design The treatment was initially given to 22 patients with advanced disease and more recently to 39 disease-free (DF) patients after radical metastasectomy. The latter group was selected in view of a theoretically better lymphocyte/tumor cell ratio and with the aim to improve disease-free and overall survival (DFS-OS) in very high risk patients. The starting IL-2 dose was 12 MlU/day (West's schedule); doses were modulated on the bases of toxicity parameters. Even though patients received different total amounts of IL-2, all of them completed the treatment. Results The treatment was offered to 22 advanced-stage cancer patients (12 melanomas, 9 colorectal carcinomas, 1 kidney carcinoma). Few and short stabilizations were observed with a median survival of 12 months (range, 3-29). Subsequently, another 39 patients were treated in an adjuvant setting after radical metastasectomy (18 melanomas, 19 colorectal carcinomas, 2 kidney cancers). Eleven out of 17 DF melanoma patients (64.7%) are still free of disease after a median of 37+ months (range, 5+ - 69+). In the group of DF colorectal cancer patients eight (44.4%) are still DF after a median of 21+ months (range, 7+ - 67+ months). One of the two patients with kidney cancer is still DF after 28+ months. Two patients (1 melanoma and 1 colorectal cancer) had just been treated and were therefore not evaluable. Severe toxicity occurred in three cases but was rapidly resolved. There was a great diversity in IL-2 doses administered; comparison of the total IL-2 dose administered between the patients who are still DF and those who progressed revealed no difference between the two groups of colorectal cancer patients, whereas melanoma patients who progressed rebeived an average IL-2 dose of 6.5 MlU/day versus 15.8 MlU/day in DF patients. No differences were observed in any of the groups between the number of TILs reinfused and clinical response. Conclusions The study is still ongoing; it has been decided to focus on DF melanoma patients after radical metastasectomy, for whom the data seem to be encouraging. Further endpoints of the study are the role of IL-2 dosage in the adjuvant setting, and the possibility to make correlations between biological parameters and clinical results.