bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning inC. elegans
Authors: Wolfe Glenn S. , Tong Vivian W. , Povse Emily , Merritt Daniel M. , Stegeman Gregory W. , Flibotte Stephane , van der Kooy Derek 
Published: August 2019

AbstractAssociative learning and sensory integration are two behavioral processes that involve the sensation and processing of stimuli followed by an altered behavioral response to these stimuli, with learning requiring memory formation and retrieval. We found that the cellular and molecular actions ofscd-2dissociate sensory integration and associative learning. This was discovered through investigation of aCaenorhabditis elegansmutation (lrn-2(mm99)) affecting both processes. After mapping and sequencing,lrn-2was found to be allelic to the gene,scd-2.scd-2-mediated associative learning and sensory integration operate in separate neurons as separate processes. We also find that memories can form from associations that are processed and stored independently from the integration of stimuli preceding an immediate behavioral decision.
Increased Severity of Neonatal Abstinence Syndrome Associated With Concomitant Antenatal Opioid and Benzodiazepine Exposure
Authors: Sanlorenzo Lauren A. , Cooper William O. , Dudley Judith A. , Stratton Shannon , Maalouf Faouzi I. , Patrick Stephen W. 
Published: August 2019

BACKGROUND:
Polysubstance use is common among opioid-using women, yet its association with pharmacotherapy for neonatal abstinence syndrome (NAS) remains unclear. We hypothesized that benzodiazepine exposure would increase risk of an infant developing pharmacologically treated NAS.

METHODS:
We conducted a retrospective cohort study of maternal-infant dyads enrolled in Tennessee Medicaid, using individual-level data linkage of vital records and administrative (ie, outpatient, inpatient, and prescription) data from 2009 to 2011. These data underwent chart review from 2013 to 2016 to obtain clinically relevant exposure data (eg, toxicology testing). The association of antenatal exposures with pharmacologically treated NAS was evaluated by using multivariable logistic regression, controlling for maternal and infant factors and clustered by hospital.

RESULTS:
Among 112 029 maternal-infant dyads, we confirmed 822 cases of NAS, of which 598 (72.7%) were cases of pharmacologically treated NAS. Infants who developed pharmacologically treated NAS were more likely to have been exposed to antenatal benzodiazepines compared with infants with confirmed NAS not treated pharmacologically (40.9% vs 30.8%; P = .008). In adjusted analyses, benzodiazepine exposure was associated with greater risk of developing pharmacologically treated NAS (odds ratio: 1.51; 95% confidence interval: 1.04–2.21). Alternatively, exposure to tobacco, marijuana, cocaine, gabapentin, and selective serotonin reuptake inhibitors were not associated with increased risk of developing pharmacologically treated NAS.

CONCLUSIONS:
Among a population of infants with intrauterine polysubstance exposure, benzodiazepine exposure was an independent predictor of an infant developing pharmacologically treated NAS. Obtaining history of antenatal benzodiazepine exposure among opioid-exposed infants may allow for risk stratification and development of personalized care plans.
Disparity in Tumor Immune Microenvironment of Breast Cancer and Prognostic Impact: Asian Versus Western Populations
Authors: Chen Ching-Hsuan , Lu Yen-Shen , Cheng Ann-Lii , Huang Chiun-Sheng , Kuo Wen-Hung , Wang Ming-Yang , Chao Ming , Chen I-Chun , Kuo Chun-Wei , Lu Tzu-Pin , Lin Ching-Hung 
Published: August 2019

Abstract

Background
The clinicopathological features and prognosis of breast cancer in Asia are different from those in the Western countries. Tumor-infiltrating immune cells can influence the outcome of patients with breast cancer, but they have not been systemically evaluated in Asian patients with breast cancer.

Methods
We compared the immune score, composition, and prognostic impact of infiltrating immune cells between Asian and Western patients with breast cancer by analyzing gene expression profiles from eight Gene Expression Omnibus data sets and The Cancer Genome Atlas data set. The Estimation of Stromal and Immune Cells in Malignant Tumours Using Expression Data (ESTIMATE) and Cell Type Identification by Estimating Relative Subsets of Known RNA Transcripts (CIBERSORT) algorithms were used to determine the immune score and composition of tumor-infiltrating immune cells, respectively.

Findings
This study included 462 Asian patients and 2,186 Western patients. Tumors of Asian patients had significantly higher immune score, particularly in the luminal B and HER2-enriched subtypes. High immune score was associated with favorable prognosis in both Asian and Western patients, and Asian race with a high ESTIMATE immune score provided additional power to predict longer disease-free survival. Activated CD4 T cells and M2 macrophages were the most strongly associated with survival in both Asian and Western patients.

Interpretation
Our study highlights the difference in tumor immune microenvironments between Asian and Western patients. The higher ESTIMATE immune score, which represents more abundant tumor-infiltrating immune cells, in tumors of Asian patients partly explains their favorable prognosis.
Discursos de Violência Contra Mulheres LBT: Invisibilidade e Silenciamento
Authors: Karpinski Mônica , Alexsandra dos Santos Kátia 
Published: August 2019

A violência contra a mulher, mesmo sendo combatida diariamente através de leis e militâncias, ainda é muito presente na sociedade brasileira, produzindo-se de diversas formas e atingindo todos os grupos de mulheres. Esta pesquisa teve como objetivo compreender os discursos sobre violência contra mulheres lésbicas, bissexuais, travestis e transexuais, entendendo que estas correm um risco particular de violência, pois, além de sofrerem pela desigualdade de gênero vigente na sociedade, escapam do padrão cis-heteronormativo. O trabalho parte da perspectiva teórico-metodológica da Análise de Discurso de Michel Pêcheux (1995). Como corpus, tomaram-se depoimentos coletados online, por meio de uma postagem em um grupo no Facebook. As violências descritas se dão no espaço público e privado, de forma mais ou menos explícita. A violência como efeito está ancorada em uma formação discursiva conservadora que toma o padrão heteronormativo como regra. A análise apontou ainda para a dificuldade de nomeação das situações de violência vividas, bem como uma política de silêncio imposta em relação à própria condição de mulher LBT.
Professor Zaynab Khabibullovna Karimova — a bright representative of Kazan school of ­microbiologists (on the 110th anniversary)
Authors: Isaeva G Sh , Khabirova G Z , Akberov A R 
Published: August 2019

The article was prepared for the 110th anniversary of the head of the department of microbiology at Kazan State Medical University, Professor Zaynab Khabibullovna Karimova. The article presents the main milestones of her biography, highlights the historical aspects of the formation of Kazan school of microbiologists, which she represented. The article was prepared using primary sources — scientific articles and monographs published during the period of her activity (20–70s of the 20th century), colleagues’ memories, archival materials of the department of microbiology named after V.M. Aristovskiy of Kazan State Medical University, as well as the family archive. The main scientific achievements of Z.H. Karimova and her scientific contribution to the development of microbiology are described, especially the study of spirochetosis. A description of experimental studies on the creation of nutrient media for the isolation of pure culture of Treponema pallidum and the search for diagnostic methods for syphilis is presented. Studies of searching for the etiological factor of jaundice of unknown origin in the Republic of Tatarstan in the 30–40s of the last century, of the detection of sources and factors of transmission of leptospirosis, the development of new methods for the diagnosis of leptospirosis and other aspects of the scientific activity of Z.H. Karimova are described.
Um caminho possível para o ensino de textos literários no ensino fundamental: oficina de contos policiais.
Authors: Souza Juliana , Garcia Roberta 
Published: August 2019

Este relato de ensino tem como objetivo demonstrar uma reflexão acerca do desafio de se ensinar a leitura de textos literários, no Ensino Fundamental, a alunos com dificuldades provenientes de um período de alfabetização deficitário, conforme constatado em entrevistas. O projeto de ensino aqui apresentado é ancorado na fundamentação teórica de Antunes (2010); Koch & Elias (2007) e Dell’Isola (2013), em relação à leitura; na perspectiva de letramento de Kleiman (1995, 2003) e na noção de gêneros de Marcuschi (2006) e Dolz e Schneuwly (2004). No ensino, o conceito de leitura como prática social deve ser relacionado aos objetivos de aprendizagem. Para tanto, é propício ao professor mediar o desenvolvimento de uma compreensão textual que exige habilidades mais complexas, para que o aluno seja capaz de relacionar aspectos textuais com conhecimento de mundo. Assim, a leitura é concebida como um fator preponderante de ampliação do letramento, favorecendo maior inserção social aos estudantes.
Sanda Reinheimer Ripeanu (dir.) (2004): Dictionnaire des emprunts latins dans les langues romanes, Bucarest, Editura Academiei Romane
Authors: Prat Sabater Marta 
Published: August 2019

Reseña de libro: Sanda Reinheimer Ripeanu (dir.) (2004): Dictionnaire des emprunts latins dans les langues romanes, Bucarest, Editura Academiei Romane.
Growth of lettuce cultivars in beds covered with differing materials
Authors: Favarato Luiz Fernando , Guarçoni Rogério Carvalho , Eutrópio Frederico Jacob , Mendes Lidiane , Piassi Mírian 
Published: August 2019

In commercial lettuce growing, the intensive cultivation of the soil results in an increase in weed populations, making it difficult to fully exploit the area and increasing production costs. Under such
circumstances, the use of soil covers can minimize this problem. Consequently, the objective of this study was to evaluate the effects of different materials as soil covers on the agronomic performance of three lettuce cultivars. The experiment was arranged in randomized blocks, with treatments set in a subdivided plot scheme. Five types of soil cover (plots) were tested: no cover, black plastic, double white faced plastic, straw mulching and kraft paper and three Lettuce cultivars (subplots): loose-crested leaf group, iceberg lettuce group, with four replicates. Number of leaves per plant, stem length and diameter, head diameter, mass of fresh and total dry matter, fresh matter mass of leaves and stem were evaluated. For the Lisa and Americana lettuce groups, bed soil cover materials were more efficient when compared to the uncovered beds. For economic and environmental reasons, kraft paper is recommended as a bedding cover material for these cultivars. Variation in growth occurred between the lettuce cultivars, independently of the use of bedding cover. This
occurred in the sequence: loose leaf > iceberg lettuce> loose-crested leaf group.
PROCENE SAVETNIKA ZA HRANITELJSTVO O POTREBI RAZVOJA DODATNIH OBUKA ZA URGENTNE HRANITELJSKE PORODICE
Authors: Marić Miljana , Mihić Ivana 
Published: August 2019

Cilј ovog rada je ispitati potrebu za revidiranjem i kreiranje novih programa obučavanja hranitelja koji realizuju urgentni porodični smeštaj, iz perspektive savetnika za hraniteljstvo. Istraživanje je realizovano kvalitativnim pristupom, fokus grupnom diskusijom koju su činili savetnici za hraniteljstvo zaposleni u Centru za porodični smeštaji usvojenje Novi Sad. Teme koje su relevantne i nalaze su u aktuelnoj obuci, iz njihove perspektive jesu: uspostavljanje odnosa sa detetom, razvojne potrebe deteta, separacija i gubitak i sistemi podrške, dok tema vaspitanja iziskuje revidiranje. Dodatne teme, koje aktuelno nisu prisutne, a potrebne su za kvalitetniju brigu jesu: navike deteta, samonega hranitelja i priprema za promenu dinamike porodice koje nastaje odlaskom deteta.
A STUDY OF MEANING IN LANGUAGE USE: LACK OF ARGUMENT IN FALLACIES
Authors: Dalilan Dalilan 
Published: August 2019

Pemakaian atau penggunaan bahasa dalam suatu kegiatan komunikasi, baik dalam bentuk lisan maupun tulisan, seringkali mengaburkan makna sejati dari informasi yang disampaikan. Dalam menyampaikan suatu pesan atau informasi sesorang seringkali mengedepankan generalisasi makna yang kadang tidak didukung oleh argumen-argumen yang logis. Bahasa politik dan iklan misalnya, syarat dngan gaya dan sikap berbahasa yang menjeneralisir fakta dengan argumen-argumen atau buah pikiran yang keliru (dalam bahasa Inggris disebut fallacies). Makalah ini mencoba mengkaji secara sederhana tentang pemakaian bahasa dalam rangka menyampaikan informasi yang mengandung makna general (bersifat umum) tetapi sejatinya memuat buah pikiran yang keliru.
SEMIOTIK TEKS ROLAND BARTHES DALAM KEHIDUPAN KONTEMPORER UMAT BERAGAMA MENGENAI FENOMENA PADU PADAN KEBAYA
Authors: Rahmawati Isnaini 
Published: August 2019

Tulisan ini mengungkap bagaimana pemikiran semiologi Roland Barthes mengenai sistem tanda dan bagaimana kebaya sebagai image clothing maupun real clothing, dapat berfungsi sebagai tanda (sign) di dalam proses produksi dengan menggunakan teori Roland tersebut serta bagaimana pandangan berbusana kebaya dalam wacana syariah islam di Indonesia. Pemikiran semiologi Roland Barthes meliputi sistem tanda, mitos, dan juga ideologi. Mengenai sistem tanda Barthes menggunakan istilah expression (ekspresi) untuk signifiant dan content (isi) untuk signifie. Dalam hal ini, teorinya bertumpu pada relasi (R) antara expression (E) dan content (C). Implementasi Semiotika Barthes dalam Fenomena Padu Padan Kebaya. Dalam penerapan semiotika Barthes, makna denotasi dan konotasi tidak dapat dipisahkan, keduanya merupakan perangkat konsep analitis yang perlu dibedakan secara ketat apabila akan dimanfaatkan untuk menganalisis dan memahami busana sebagai fenomena kultural yang bermakna. Penyingkronan dengan kehidupan beragama-pun telah teratasi, terutama dalam agama Islam, telah banyak kebaya yang sengaja dirancang untuk wanita muslimah, dan muslimah sejati bisa memilih dan memilah yang sesuai dengan tuntunan agamanya.

Kata kunci: Semiologi, Roland Barthes, Ekspresi, content, kebaya.
Pengaruh Perbedaan Gaya Belajar dan Keikutsertaan Organisasi Terhadap Pemahaman Hasil Pembelajaran Mahasiswa
Authors: Febrianti Nia Savira 
Published: August 2019

This article is made based on the diversity of different learning styles and student interest in talent, especially participation in organizational activities. This article was made with the aim to find out the different learning styles for each student and the participation of organizational activities and their influence in gaining understanding and learning outcomes. The differences in learning styles and talent interests of each student are abilities in themselves. Teachers can also play a role in helping understanding learning in each individual who has different learning styles and interests. In this article it can be seen that organizational activities have positive and negative influences in learning and learning outcomes. The writing of this article uses the literature study method, by looking at various sources or references, such as books or several other journals concerning the same material as the article I made. With this article, it can be taken as a reference in learning. Thus, learning goals can be achieved without having to put pressure on students.

Kata Kunci: learning style, interest in talent, organizational activities, understanding of learning
Peningkatan Literasi Sains Melalui Pembelajaran Berbasis Scientific Approach
Authors: Utami Arfiati Ulfa , Murti Selly Candra Citra 
Published: August 2019

Penelitian ini bertujuan untuk mengetahui hasil penerapan pembelajaran berbasis scientific approach yang digunakan untuk meningkatkan literasi sains siswa. Penelitian ini merupakan Quasi eksperimen dengan pretest-posttest control group design untuk mengetahui hasil penerapan pembelajaran berbasis scientific approach terhadap literasi sains siswa. Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMPN 1 Srono dengan sampel kelas VII.1 sebagai kelas kontrol dan kelas VII.2 sebagai kelas eksperimen. Penentuan sampel tersebut menggunakan teknik purposive sampling dengan pertimbangan tertentu. Instrumen penelitian berupa lembar wawancara dan tes literasi sains. Hasil penerapan pembelajaran berbasis scientific approach dan perangkat pembelajarannya diperoleh peningkatan literasi sains berdasarkan nilai N-gain pada kelaskontrol sebesar (kategori rendah), sedangkan pada kelas eksperimen sebesar (kategori sedang). Hasil penelitian dan pembahasan disimpulkan bahwa penerapan pembelajaran berbasis scientific approach dan perangkat pembelajaran yang diperoleh dapat digunakan untuk meningkatkan literasi sains siswa

Keywords: literasi sains, pembelajaran berbasis scientifi approach, perangkat pembelajaran
PENGARUH GAME ONLINE PUBG (Player Unknown’s Battle Ground) TERHADAP PRESTASI BELAJAR PESERTA DIDIK
Authors: Fauzi Ach 
Published: August 2019

ABSTRAK
Salah satu permainan berbasis online yang sedang populer sekarang adalah PUBG. Permainan berbasis online ini baik digunakan sebagai alternatif rekreasi pelajar namun harus disertai kontrol diri karena jika pemain sudah mulai kecanduan akan berakibat prestasi akademik menurun. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan teknik pengumpulan data berupa metode observasi, metode wawancara. Tujuan dari penelitian ini yaitu menjelaskan bagaimana pengaruh game online PUBG pada prestasi akademik Siswa. Hasil penelitian dapat disimpulkan bahwa pengaruh game online PUBG terhadap prestasi belajar siswa menyatakan bahwa salah satu permainan berbasis online ini sangat digemari karena mendapat kesenangan, mengurangi stress, bertemu dan berkenalan dengan banyak teman, gratis, meningkatkan kerjasama, meningkatkan kempampuan berbahasa inggris, terhindar dari pergaulan bebas dan narkoba, dan permainan yang dapat dimainkan dimana dan kapan saja, namun setiap permainan jika tidak diimbangi dengan kontrol diri maka akan membuat pemainnya kecanduan dan membuat prestasi belajar siswa menurun.
Kata Kunci : Game Online; PUBG; Prestasi Belajar
STUDI LITERATUR PENTINGNYA PENERAPAN PENDIDIKAN KARAKTER BAGI PENDIDIKAN FORMAL SEKOLAH MENENGAH PERTAMA
Authors: Mayshandy Muhammad Fiky 
Published: August 2019

Abstract
Character education of junior high schools in Indonesia is arguably less preferred. In fact, it only becomes limited to discourse in formal education. This article discusses the importance of character education in formal education. Starting from looking example of applications in China. Then, the business continued its application in formal junior high school education. These efforts include the establishment of character education as one of the reasons why the important of character building for student capital to mature.

Keywords: character education, design
Characteristic of Referral Patients With Severe Preeclampsia In Surabaya
Authors: Adeline Myrna Evanda , Laksana Muhammad Ardian Cahya , Atika S 
Published: August 2019

Introductions: Pre-eclampsia is a hypertensive disorder of a pregnancy that remains major maternal mortality in developing country. Severe pre-eclampsia needed an advanced medical treatment since it could cause life treathening condition for both mother and fetus. The purpose of this research was to understand and got the picture of the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclamptic mother in dr. Soetomo General Hospital during 2011.Methods: This research is a retrospective-descriptive research which observed the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclampsia mother This research used medical record then the data was recorded and analyzed descriptively.Result: The number of patients who met the inclusion criteria were 239 patients. Patient’s age were distributed unimodally with a peak at productive age. Most of patients had previous history of pregnancy. Pulmonary edema was the most common cause of maternal complication and intra uterine fetal death was the most common cause of fetal complication. Most delivery were performed in Sectio Caesaria method. Almost all cases was direct refferal cases from other medical services. Then most of cases was reaching aterm periode. Most of babies were born with body weight ≥ 2500 gram. And based on Apgar score the babies were well adapted.Conclusions: Most of the patients with severe preeclampsia referrals were referred from a health care setting, only a small percentage of women were referred to relay. Most of severe preeclampsia occured in women with their gestational age has reached 37 weeks.
Consequences of Overweight and Obesity in Adolescence against the Risk of Hypertension in Adulthood
Authors: Simbolon Demsa , Yorita Epti , Talib Ruzita ABD 
Published: August 2019

Population increase in adolescence are associated with increased overweight and obesity problems. If this problem not early intervention will have an impact on increasing hypertension prevalence and risk of death. This research aimed to explain the consequences of overweight and obesity in adolescent to hypertension in adults. The study used Indonesian Family Life Survey (IFLS) data with a retrospective cohort study. Adolescent BMI measurements on 2007 and the risk of hypertension on 2014. Population are all adolescents aged 10-20 years in 2007. Sample of 1,697 adolescent who randomly IFLS 2007 with the inclusion criteria: biological children and a single birth, children living with biological parents, children remain alive until adulthood on 2014. Multivariate analysis used logistic regression. The study found 8.1% women and 5.6% men were overweight and obes. In adulthood, there was a 45.4% incidence of hypertension. Incidence of hypertension in men (67.3%) more than women (26.8%). The multivariate model showed adolescence BMI affects the blood pressure after controlled the BMI adult, adolescence blood pressure, area of residence, and gender.Gender interacts with adolescence BMI. The risk of hypertension in adulthood based on overweight and obese in adolescent boys is 3 times and girls is 2 times.