bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Muscle Fatigue Progression during Dynamic Exercise
Authors: RANNOU FABRICE , NYBO LARS , ANDERSEN JANNI ENGHAVE , NORDSBORG NIKOLAI B. 
Published: February 2019

ABSTRACT

Purpose
To develop and validate a novel model for assessment of peripheral fatigue progression during dynamic exercise.

Methods
Seven males and four females (24 ± 3 yr) completed one-legged knee-extensor exercise at 40% of peak power output (PPO) for 12 min (40% PPO). Additionally, an exhaustive bout lasting approximately 6 min (84% ± 2% PPO; 59 ± 10 W) was contrasted to two bouts completed at ±5% of the target workload. Trials were completed in randomized order. Percutaneous electrical stimulation of m. vastus lateralis during the passive knee-flexion phase allowed quantification of maximal twitch force every 30 s in parallel with RPE.

Results
Elicited twitch force remained unchanged during the 40% PPO trial. During the three exhaustive bouts, exercise differed in duration (561 ± 154 s, 366 ± 64 s, 245 ± 61 s; P < 0.001) and amplitude of elicited twitch force showed a curvilinear decline across time. Elicited twitch force at exhaustion was approximately 60% reduced and similar between the exhaustive trials (intraclass correlation coefficient, 0.76; 95% confidence interval, 0.48–0.92). The increase in RPE during exercise was strongly correlated to the gradually reduced evoked twitch force (repeated-measures correlation, 0.89; 95% confidence interval, 0.62–0.97).

Conclusions
The developed model permits quantification of muscle fatigue progression during continuous dynamic one-legged knee-extension and a biphasic fatigue pattern is demonstrated during intense exercise. The model is sensitive to small changes in intensity, and it provides a novel approach for studying muscular mechanisms and their temporal relation to fatigue progression in vivo.
Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.
Authors: Devkota Kiran , He Maio , Liu Meng Yi , Li Yan , Zhang You Wei 
Published: February 2019

The Epstein-Barr virus (EBV) is a common virus in humans and the most common causative agent of Infectious Mononucleosis. EBV primary infection has recently risen in some countries and children below 2 years of age are highly susceptible. The clinical manifestations in children with EB virus infection involve multiple systems, causing severe illness, meaning attention should be paid during diagnosis and treatment. Objective: This single institution based retrospective study was carried out with the aim of estimating the overall prevalence of EBV infection and identifying high-risk age group among children. Methods: This study include total 253 patients under 15 years of age found to be positive for EBV DNA by serum PCR who were admitted to the Pediatrics Department of Renmin Hospital,(Shiyan, China) during a 4-year period from 2014 to 2017. Patients were divided into three groups; 0-<4years, 4-<6years and 6-<15years. We then calculated the percentage and prevalence of EBV DNA-positive cases. Results: The yearly EBV prevalence rate was 4.99 per 1000 admissions in 2014, 6.97 per 1000 admissions in 2015, 10.42 per 1000 admissions in 2016, and 12.16 per 1000 admissions in 2017. Out of 253 EBV-positive cases, those under 4 years had the highest rate of EBV infection (74.7%). The rate drops to 11.06% in the 4-6 years group, and was 14.22% in the 6-15 years group. Those between 6 months and 1 year are those at the highest risk. Conclusion: The rate of hospital admission of children due to EBV infection is increasing day by day. Children under 4 years of age are highly susceptible to infection and children of age between 6 months and 1 year are the high-risk group for EBV infection.
A physiological examination of perceived incorporation during trance
Authors: Wahbeh Helané , Cannard Cedric , Okonsky Jennifer , Delorme Arnaud 
Published: February 2019

Background:Numerous world cultures believe channeling provides genuine information, and channeling rituals in various forms are regularly conducted in both religious and non-religious contexts. Little is known about the physiological correlates of the subjective experience of channeling.Methods:We conducted a prospective within-subject design study with 13 healthy adult trance channels. Participants alternated between 5-minute blocks of channeling and no-channeling three times while electroencephalography (EEG), electrocardiography (ECG), galvanic skin response (GSR), and respiration were collected on two separate days. Voice recordings of the same story read in channeling and no-channeling states were also analyzed. Results:The pre-laboratory survey data about demographics, perception of the source, purpose and utility of channeled information reflected previous reports. Most participants were aware of their experience (rather than in a full trance) and had varying levels of perceived incorporation (i.e. control of their body). Voice analysis showed an increase in voice arousal and power (dB/Hz) differences in the 125 Hz bins between 0 and 625 Hz, and 3625 and 3875 Hz when reading during the channeling state versus control. Despite subjective perceptions of distinctly different states, no substantive differences were seen in EEG frequency power, ECG measures, GSR and respiration.Conclusions:Voice parameters were different between channeling and no-channeling states using rigorous controlled methods, but other physiology measure collected were not. Considering the subjective and phenomenological differences observed, future studies should include other measures such as EEG connectivity analyses, fMRI and biomarkers.
Effects of a topical botanically-enriched salve on cutaneous oxygenation
Authors: Corroon Jamie , Erlandsen Andrew , Taylor Jan , Hanes Doug , Bradley Ryan 
Published: February 2019

Objective: There is a medical need to evaluate new treatments that may improve wound healing. This study aimed to determine if Original Healing Salve (OHS, Puremedy, Inc.) a topical, botanically-enriched salve (BES), changes distal leg tissue oxygenation in people with type 2 diabetes. Method: A randomised, controlled, crossover, double-blinded clinical trial comparing changes in cutaneous oxygen delivery (mean TcPO2) on multiple sites of the lower extremity following application of a botanically-enriched topical salve, as compared with application of the salve's base in patients with type 2 diabetes. Subjects were recruited from the general population as a convenience sample. Results: A total of 16 participants were recruited. Analysis of the primary outcome demonstrated no statistically significant difference in TcPO2 at 30 minutes postapplication when comparing the BES to the base salve (BS) on the leg (–0.39±8.54mmHg; p=0.86). Analyses of secondary outcomes at 30 minutes postapplication indicated that mean TcPO2 was significantly higher than preapplication levels among subjects receiving both the BES (3.70±6.62mmHg; p=0.04) and BS on the leg (4.08±5.21mmHg; p=0.007). On the foot, mean TcPO2 at 30 minutes postapplication was higher in the BES compared with the BS, this difference was not significant (0.98±8.59mmHg; p=0.66). Mean TcPO2 was higher than preapplication levels among subjects receiving both the BES (1.21±7.70mmHg; p=0.54) and BS on the foot (2.19±7.27mmHg; p=0.25). These differences were non-significant. Conclusion: These findings support consideration of topical treatments containing botanical ingredients to increase cutaneous oxygen delivery in the lower extremity in patients with type 2 diabetes.
Pilot study to assess the use of a fluorescence imaging system for assessment of amputation healing
Authors: Hutchison Dylan , Cuff Robert , Liao Tim , Korepta Lindsey , Simmons Justin , Rudy Monica , Holen Jeanine , Hiller Jill Ann , Brock Taylor Ten , Rozwadowski Michael 
Published: February 2019

Objective: The purpose of this study was to use a fluorescence imaging system (FIS) (SPYElite, NOVADAQ, US) during lower extremity amputations and develop parameters to predict amputation healing, for which there are no proven, objective tests. We hypothesised that the FIS may identify areas of poor perfusion at the time of amputation and predict potential healing complications. There are no studies involving the FIS used in this study in lower extremity amputation. Method: This prospective cohort study involved patients requiring either below- or above-knee-amputation at one, mid-western medical centre. The FIS was used as per manufacturer's instructions after wound closure and before dressing. Procedure and operative management was unchanged. Through the FIS, perfusion values were plotted along the amputation site to visualise and quantify intraoperative perfusion and to compare with 30-day postoperative amputation healing. Results: Surgeons determined that all of the 18 participants had adequate perfusion at surgical wound closure. At 30 days, two subjects had wound dehiscence or infection; these correlated with low perfusion values on the FIS imaging. A further six subjects had marginal or low perfusion values, but did not develop wound failure. Conclusion: It is feasible to use the FIS during amputation, however it did not perfectly predict healing course based on vascular perfusion. There were interesting patterns of poor perfusion that correlated with areas of dehiscence or infection but other patients had reduced perfusion that healed well. Due to the small sample size, no discernible perfusion value differences existed between patients who healed and patients with healing complications. A future, larger study may show that the FIS can be predictive of patient healing and aid decisions for intraoperative revision.
Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer
Authors: Sans Marta , Zhang Jialing , Lin John Q , Feider Clara L , Giese Noah , Breen Michael T , Sebastian Katherine , Liu Jinsong , Sood Anil K , Eberlin Livia S 
Published: February 2019

AbstractBACKGROUNDAccurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems.METHODSMasSpec Pen analyses were performed on 192 ovarian, fallopian tube, and peritoneum tissue samples. Samples were evaluated by expert pathologists to confirm diagnosis. Performance using an Orbitrap and a linear ion trap mass spectrometer was tested. Statistical models were generated using machine learning and evaluated using validation and test sets.RESULTSHigh performance for high-grade serous carcinoma (n = 131; clinical sensitivity, 96.7%; specificity, 95.7%) and overall cancer (n = 138; clinical sensitivity, 94.0%; specificity, 94.4%) diagnoses was achieved using Orbitrap data. Variations in the mass spectra from normal tissue, low-grade, and high-grade serous ovarian cancers were observed. Discrimination between cancer and fallopian tube or peritoneum tissues was also achieved with accuracies of 92.6% and 87.9%, respectively, and 100% clinical specificity for both. Using ion trap data, excellent results for high-grade serous cancer vs normal ovarian differentiation (n = 40; clinical sensitivity, 100%; specificity, 100%) were obtained.CONCLUSIONSThe MasSpec Pen, together with machine learning, provides robust molecular models for ovarian serous cancer prediction and thus has potential for clinical use for rapid and accurate ovarian cancer diagnosis.
Influence of Body Mass Index on Outcomes of Patients Undergoing Surgery for Acute Aortic Dissection: A Propensity-Matched Analysis
Authors: Lio Antonio , Bovio Emanuele , Nicolò Francesca , Saitto Guglielmo , Scafuri Antonio , Bassano Carlo , Chiariello Luigi , Ruvolo Giovanni 
Published: February 2019

To determine whether body mass index ≥30 kg/m2 affects morbidity and mortality rates in patients undergoing surgery for type A acute aortic dissection, we conducted a retrospective study of 201 patients with type A dissection. Patients were divided into 2 groups according to body mass index (BMI): nonobese (BMI, <30 kg/m2; 158 patients) and obese (BMI, ≥30 kg/m2; 43 patients). Propensity score matching was used to reduce selection bias.
The overall mortality rate was 19% (38/201 patients). The perioperative mortality rate was higher in the obese group, both in the overall cohort (33% vs 15%; P=0.01) and in the propensity-matched cohort (32% vs 12%; P=0.039). In the propensity-matched cohort, patients with obesity had higher rates of low cardiac output syndrome (26% vs 6%; P=0.045) and pulmonary complications (32% vs 9%; P=0.033) than those without obesity. The overall 5-year survival rates were 52.5% ± 7.8% in the obese group and 70.3% ± 4.4% in the nonobese group (P=0.036). In the propensity-matched cohort, the 5-year survival rates were 54.3% ± 8.9% in the obese group and 81.6% ± 6.8% in the nonobese group (P=0.018).
Patients with obesity (BMI, ≥30 kg/m2) who underwent surgery for type A acute aortic dissection had higher operative mortality rates and an increased risk of low cardiac output syndrome, pulmonary complications, and other postoperative morbidities than did patients without obesity. Additional extensive studies are needed to confirm our findings.
Spontaneous Resolution of Residual Shunting in 2 Compromised Patients after Amplatzer Occlusion of Postinfarction Ventricular Septal Defects
Authors: Yanagiuchi Takashi , Tada Norio , Suchi Taro , Mizutani Yukiko , Matsumoto Takashi , Sakurai Mie , Ootomo Tatsushi 
Published: February 2019

Ventricular septal defect (VSD) is a rare, potentially fatal complication of acute myocardial infarction. When surgical closure is contraindicated, transcatheter closure may be an alternative. Residual shunting after transcatheter closure of postinfarction VSDs has been reported; however, we found few cases of this in patients who also had severe heart failure or hemolysis.
We report 2 closures of postinfarction VSDs with use of the Amplatzer Septal Occluder. Both elderly patients—one with severe heart failure, one with persistent hemolysis, and neither a surgical candidate—had high-velocity residual shunting through the occluders. We intensively managed the patients' conditions and used angiography and transthoracic echocardiography to record the gradual disappearance of each shunt over 4 months—the first such serial monitoring of which we are aware. We think that even substantial shunting in the presence of severe heart failure or hemolysis can eventually resolve spontaneously, assuming effective management of the concomitant medical conditions.
Multi-dimensional periodic problems for higher-order linear hyperbolic equations
Authors: Kiguradze Tariel , Al Jaber Noha 
Published: February 2019

Abstract
For higher-order linear hyperbolic equations the problem on periodic solutions is investigated. The concepts of associated problems, and α-well-posedness are introduced.
Necessary and sufficient conditions of well-posedness in the two-dimensional case, as well as unimprovable sufficient conditions of well-posedness and α-well-posedness in the multi-dimensional case are established.
Construction of Green’s functional for a third order ordinary differential equation with general nonlocal conditions and variable principal coefficient
Authors: Özen Kemal 
Published: February 2019

Abstract
In this work, the solvability of a generally nonlocal problem is investigated for a third order linear ordinary differential equation with variable principal coefficient. A novel adjoint problem and Green’s functional are constructed for a completely nonhomogeneous problem. Several illustrative applications for the theoretical results are provided.
L2L^{2} boundedness for commutators of fractional differential type Marcinkiewicz integral with rough variable kernel and BMO Sobolev spaces
Authors: Chen Yanping , Ding Yong , Zhu Kai 
Published: February 2019

Abstract
In this paper, for

0
<
γ
<
1

{0<\gamma<1}

and

b
∈

I
γ

⁢

(
BMO
)

{b\in I_{\gamma}(\mathrm{BMO})}

, the authors give the

L
2

⁢

(

ℝ
n

)

{L^{2}({\mathbb{R}}^{n})}

boundedness of

μ

γ
;
b

{\mu_{\gamma;b}}

, the commutator of a fractional
differential type Marcinkiewicz integral with rough variable kernel,
which is an extension of some known results.
The probabilities of winning a racquetball doubles match motivate a fairer side-out scoring scheme for singles and team events
Authors: Peters James E. , Peters Christopher J. 
Published: February 2019

Abstract
We explore the probabilities of winning a best-of-three doubles racquetball match given the probabilities that each of the participants wins a point while serving. We restrict our attention to the cases where these probabilities are between 0.4 and 0.6 for all participants; in other words, the cases where all of the players are moderately evenly matched. In doing so, we find it sensible to suggest changes to the side-out scoring schemes in singles and in team events. These changes would cause each game played to be more fair while preserving the fairness of a match, for which there seems to be adequate impetus.
Population trends of Peregrine Falcon in Northern Spain – Results of a long-term monitoring project
Authors: Zuberogoitia Iñigo , Morant Jon , Castillo Iñaki , Martínez Jose Enrique , Burgos Gorka , Zuberogoitia Julen , Azkona Ainara , Guijarro Julio Ruíz , González-Oreja Jose Antonio 
Published: February 2019

AbstractWe monitored Peregrine Falcon(Falco peregrinus)population in Bizkaia, Northern Spain, during two decades (1998–2017). Our population increased from 34 to 47 territorial pairs, as did other European populations until the first years of the 21stcentury, and then declined until 34 territorial pairs in 2017. The combination of catastrophic events (Prestige oil spill), increasing rain in winter and spring, and direct and indirect mortality factors significantly affected incubation onset, productivity and population stability, which in turn could impact on the floater population. Rain in February significantly affected incubation onset, which showed a slight positive trend during the last decade. Juvenile females laid 12 days later than adults, and each adult female started incubation in the same dates every year. However, the proportion of juvenile females did not significantly increase as might have been expected. Moreover, productivity was inversely related to incubation onset dates. Rain in April and May also affected productivity, and combined with short term extreme weather events determined a decreasing productivity during the last decade. Moreover, apart from human persecution (which caused 40.30% of the known deaths of Peregrines), we found 18 cases of breeders affected by infectious diseases, also related to weather. The combined effects of these factors, and the low availability of adequate nesting sites, negatively affected (i) territorial populations, (ii) productivity, and (iii) floater population, which in turn also determined territorial population and productivity.
Onset of natal dispersal in Peregrine Falcon from Mediterranean islands (Italy)
Authors: Bond Salvatore , Guzzo Enrico , Mascara Rosario , Sarà Maurizio 
Published: February 2019

Abstract
Basic information on natal dispersal of Peregrine Falcons is virtually lacking in Europe, despite increased attention on this species, and the sensitivity of this stage in the Peregrines’ life history. In this study, we collected satellite telemetry data during the onset of natal dispersal of 19 Peregrine Falcons tagged in Sicily and the Aeolian archipelago (Italy). We divided the onset of dispersal into the following 3 periods: post-fledging dependence period (PFDP), wandering, and wintering. PFDP lasted on average 47±16 days, during which young peregrines moved very little (0.167 km), and explored small areas (0.226 km2) far from the nest cliff, and showed no sex differences. The wandering phase was highly individualistic, with median net displacements of 23.97 km. Both PFDP and wandering bearings were oriented towards NNE-ESE. Only five individuals went sporadically outside the island borders. During their first winter, Peregrines had a mean home range of 135.65±82.31 km2 spatially scattered across Sicily and mainly composed of open habitats, like cereal steppes, arboreal crops and agri-mosaics. Individuals had a dissimilar assortment in habitat composition, however the urban habitat was the most selected and the woodland the least. At night, during both wandering and wintering phases Peregrines used rocks, cliffs and electricity pylons in frequencies not statistically different between sex, phase and type of roost. Only two individuals had significant use of pylons and one of rocks. The multifaceted framework of Peregrine Falcon’s natal dispersal was described here for the first time in a Mediterranean population.
Dynamic Correspondence of Resistance Training to Sport: A Brief Review
Authors: Suarez Dylan G. , Wagle John P. , Cunanan Aaron J. , Sausaman Robert W. , Stone Michael H. 
Published: February 2019

ABSTRACTTHE PROPER APPLICATION OF THE PRINCIPLE OF SPECIFICITY IS ESSENTIAL TO ANY STRENGTH AND CONDITIONING PROGRAM. HOWEVER, THE TRANSFER OF RESISTANCE TRAINING TO SPORT IS HIGHLY COMPLEX, DIFFICULT TO PREDICT, AND CHALLENGING TO ASSESS. THIS BRIEF REVIEW EXAMINES THE PRINCIPLE OF DYNAMIC CORRESPONDENCE AS AN AID TOWARD BETTER UNDERSTANDING AND PREDICTING AN EXERCISE OR TRAINING METHOD'S POTENTIAL TRANSFER TO SPORT. PRACTICAL TRAINING RECOMMENDATIONS ARE GIVEN BASED ON THE RESEARCH REVIEWED.
Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele
Authors: Korecki Andrea J , Hickmott Jack W , Lam Siu Ling , Dreolini Lisa , Mathelier Anthony , Baker Oliver , Kuehne Claudia , Bonaguro Russell J , Smith Jillian , Tan Chin-Vern , Zhou Michelle , Goldowitz Daniel , Deussing Jan M , Stewart A Francis , Wasserman Wyeth W , Holt Robert A , Simpson Elizabeth M 
Published: February 2019

Abstract
To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To address these problems, a high-throughput method for large-scale production that produces high-quality results is necessary. Further, endogenous promoters need to be chosen that drive cell type specific expression, or we need to further focus the expression by manipulating the promoter. Here we test the suitability of using knock-ins at the docking site 5′ of Hprt for rapid development of numerous cre-driver strains focused on expression in adulthood, using an improved cre tamoxifen inducible allele (icre/ERT2), and testing a novel inducible-first, constitutive-ready allele (icre/f3/ERT2/f3). In addition, we test two types of promoters either to capture an endogenous expression pattern (MaxiPromoters), or to restrict expression further using minimal promoter element(s) designed for expression in restricted cell types (MiniPromoters). We provide new cre-driver mouse strains with applicability for brain and eye research. In addition, we demonstrate the feasibility and applicability of using the locus 5′ of Hprt for the rapid generation of substantial numbers of cre-driver strains. We also provide a new inducible-first constitutive-ready allele to further speed cre-driver generation. Finally, all these strains are available to the research community through The Jackson Laboratory.