bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Radiocarbon Dating Results from the Upper Paleolithic–Mesolithic Levels in Grotta Romanelli (Apulia, Southern Italy)
Authors: Calcagnile Lucio , Sardella Raffaele , Mazzini Ilaria , Giustini Francesca , Brilli Mauro , D’Elia Marisa , Braione Eugenia , Conti Jacopo , Mecozzi Beniamino , Bona Fabio , Iurino Dawid Adam , Lembo Giuseppe , Muttillo Brunella , Quarta Gianluca 
Published: May 2019

ABSTRACTIn this paper, we present the results of the accelerator mass spectrometry radiocarbon (AMS14C) dating campaign performed on samples selected from different levels in Grotta Romanelli (Castro, Italy). Grotta Romanelli is one of the key sites for the chronology of Middle Pleistocene–Holocene in Mediterranean region. After the first excavation campaigns carried out in the first decades of the 1900s, the cave has been systematically re-excavated only since 2015. During the last excavation campaigns different faunal remains were selected and submitted for 14C dating in order to confirm the chronology of the cave with a higher resolution. Isotopic ratio mass spectrometry (IRMS) measurements were also carried out on faunal remains.
EU AGENCIFICATION AND THE RISE OF ESMA: ARE ITS GOVERNANCE ARRANGEMENTS FIT FOR PURPOSE?
Authors: Howell Elizabeth 
Published: May 2019

AbstractEU agencies have mushroomed in recent years and new agencies, such as those in the financial arena, can have far-reaching quasi-regulatory and supervisory powers. These developments raise fundamental questions as to their constitutional standing, the delegation of powers and how to wrestle the challenges of independence and accountability. This paper considers ESMA, the most ambitious new financial sector agency. It examines ESMA's governance and accountability mechanisms and makes normative proposals to better balance the competing supranational and national interests within it. Such refinements should also be implemented in conjunction with additional accountability requirements, particularly a greater role for the European Parliament. This reshaping is vital to guarantee ESMA's autonomy and legitimacy.
Active and recent deformation at the Southern Alps – Ligurian basin junction
Authors: Larroque C. , Béthoux N. , Calais E. , Courboulex F. , Deschamps A. , Déverchère J. , Stéphan J.-F. , Ritz J.-F. , Gilli E. 
Published: May 2019

AbstractThe Southern Alps – Ligurian basin junction is one of the most active seismic areas in Western Europe countries. The topographic and the structural setting of this region is complex because of (i) its position between the high topography of the Southern Alps and the deep, narrow Ligurian oceanic basin, and (ii) the large number of structures inherited from the Alpine orogeny. Historical seismicity reveals about twenty moderate-size earthquakes (up to M=6.0), mostly distributed along the Ligurian coast and the Vésubie valley. A recent geodetic experiment shows a significant strain rate during the last 50 years in the area between the Argentera massif and the Mediterranean coastline. Results of this experiment suggest a N-S shortening of about 2-4 mm/yr over the network, this shortening direction is consistent with the seismological (P-axes of earthquakes) and the microtectonic data. The Pennic front (E-NE of the Argentera massif) and the northern Ligurian margin are the most seismically active areas. In the Nice arc and in the Argentera massif, some seismic lineaments correspond to faults identified in the field (such as theTaggia-Saorge fault or the Monaco-Sospel fault). In the western part of the Alpes Maritimes, no seismic activity is recorded in the Castellane arc. In the field, geological evidence, such as offsets of recent alluvial sediments, recent fault breccia, speleothem deformations, radon anomalies and others indicates recent deformation along these faults. Nevertheless, to this date active fault scarps have not been identified: this probably results from a relatively high erosion rate versus deformation rate and from the lack of Quaternary markers. We also suspect the presence of two hidden active faults, one in the lower Var valley (Nice city area) and the other one at the base of the Argentera crustal thrust-sheet. Offshore, along the northern Ligurian margin, the seismic reflection data shows traces of Quaternary extensional deformation, but the accuracy of the data does not yet allow the construction of a structural map nor does it allow the determination of the continuity between the offshore and onshore structures. From these data set we propose a preliminary map of 11 active faults and we discuss the questions which remain unsolved in the perspective of seismic hazard evaluations.
Modelling of speleothems failure in the Hotton cave (Belgium). Is the failure earthquake induced?
Authors: Cadorin J.F. , Jongmans D. , Plumier A. , Camelbeeck T. , Delaby S. , Quinif Y. 
Published: May 2019

AbstractTo provide quantitative information on the ground acceleration necessary to break speleothems, laboratory measurements on samples of stalagmite have been performed to study their failure in bending. Due to their high natural frequencies, speleothems can be considered as rigid bodies to seismic strong ground motion. Using this simple hypothesis and the determined mechanical properties (a minimum value of 0.4 MPa for the tensile failure stress has been considered), modelling indicates that horizontal acceleration ranging from 0.3 m/s2 to 100 m/s2 (0.03 to 10g) are necessary to break 35 broken speleothems of the Hotton cave for which the geometrical parameters have been determined. Thus, at the present time, a strong discrepancy exists between the peak accelerations observed during earthquakes and most of the calculated values necessary to break speleothems. One of the future research efforts will be to understand the reasons of the defined behaviour. It appears fundamental to perform measurements on in situ speleothems.
Palaeoseismic investigations in Belgian eaves
Authors: Delaby S. 
Published: May 2019

AbstractIn some karstic caves, the observation of numerous broken stalagmites may provide potential secondary evidence for intense palaeoearthquakes during recent past times. We have named these morpho-sedimentologic features seismothems. A methodology has been developed to discriminate broken speleothems due to earthquake-induced effects or caused by other mechanisms. A study has been carried out in the Belgian karst areas. In the Vesdre Valley, it seems difficult to find evidence of the well-known Verviers earthquake, probably the most destructive historical earthquake known in Belgium which occurred in 1692 AD. The most important concentration of broken stalagmites was discovered in the caves between Hotton and Han-sur-Lesse. The observations in the cave of Hotton suggest a seismic origin, the other origins can not be the cause of the speleothem break. This result implies a strong earthquake situated close to the cave. A preliminary AMS14C age suggests a minimum age of 10100 ±1200 cal14C yr BR for one stalagmite rupture in the Hotton cave.
Letters from the Malay Sultanates of the 17th and 18th Centuries: An Unknown Collection in St. Petersburg
Authors: Katkova Irina R. 
Published: May 2019

AbstractThis article deals with Malay letters and documents from the archives of the Dutch East India Company (Vereenigde Oostindische Compagnie—VOC), dating to the seventeenth and eighteenth centuries. The collection of “golden” Malay letters, which belonged to the governor- general of the VOC in Java (1704–1709) Joan van Hoorn, made a long voyage on the shipSandenburgfrom Batavia to Cape Town and Amsterdam in 1710. Its cultural and historical value was firstly estimated by the outstanding Russian scholar and antiquarian N. P. Likhachev, who purchased it for the Paleographical Museum in Petrograd (St. Petersburg) in 1910. The pages of the fifty-seven diplomatic letters cover one of the most controversial periods of VOC history on the Archipelago, 1683 to 1710, the establishment of its relationships with local nobility and states. The collection represents the original letters of the sultans of Palembang, Gowa, Buton, Bone, Tallo, Banten, and Cirebon, and of prominent historical figures of Malay states as well as the famous Indian merchant from Surat, Abdul Ghafur. They are written in Malay (in Arabic graphic: Jawi and Pegon), Arabic, Javanese (in two scripts: Pegon and Carakan), Dutch, Spanish, Persian, and Chinese. Their investigation will contribute to the academic scholarship on the famous records, reconstructing the history of the Dutch East India Company (VOC) on the Malay Archipelago, and on the peculiarities of Malay letter writing in different languages, scripts, and regions.
The Ordeals of Colonial Contracting: Reactions to and Repercussions of Two Failed State-Private Ventures in Habsburg Portugal (1622–1628)
Authors: Pereira Edgar 
Published: May 2019

AbstractAmong the solutions devised by early modern Western European states to engage with the private sector in the governance of their overseas empires, the adjudication of revenue farms and colonial monopolies was often dismissed by historians on the grounds of being coercive, inefficient, and risk-exempt for the contractors. In reality, however, the threat of financial hardship and insolvency was very real, and not infrequently led to contractual removal, the seizure of collateralized assets, and even the imprisonment of the concessionaires.This article approaches the neglected topic of failure in big business in early seventeenth-century Portugal, an overlooked case of a contractor state that relied extensively on the adjudication of government contracts to finance and rule its overseas empire. By looking into the downward trajectories of two tax-farmers and the collapse of their contractual dealings, light will be shed on how the Crown and private entrepreneurs reacted to the repercussions of failure in these early modern public-private partnerships. It will also be shown how the road leading to termination was very much shaped by the political relationships between the Crown and its contractors and can only be understood in the context of wider relationships of brokerage, credit, and service between the two.
Post partum suboestrus in dairy cows : comparison of treatment with prostaglandin F2α or GnRH + prostaglandin F2α + GnRH
Authors: Grimard B. , Laumonnier G. , Ponsart C. , Fauxpoint H. , Barassin E. , Ponter A.A. , Deletang F. , Mialot J.P. 
Published: May 2019

AbstractTwo studies (expt. 1, 185 cows in 1996/97; expt. 2, 168 cows in 1997/98) were conducted with Prim ‘Holstein dairy cows in the Mayenne region (France) to investigate suboestrus. Cows which had not been observed in oestrus since calving were allocated alternately to treatment groups between 60 and 90 days post partum. Expt. 1. Group 1: GnRH (Day 0, 100 μg im), PGF2α (Day 7, 25 mg im), GnRH (Day 9, 100 μg im) with artificial insemination (AI) Day 10. Group 2 : PGF2α (Day 0, 25 mg im), AI at oestrus or if oestrus not observed a second PGF2α injection was given (Day 13) with AI on Day 16 and Day 17. Expt. 2. Group 1 : GnRH (Day 0, 100 /μg im), PGF2α (Day 7, 25 mg im), GnRH (Day 9, 100 μg im) with AI at observed oestrus after Day 0 or at Day 10 if oestrus not observed. Group 2 : PGF2α (Day 0, 25 mg im), AI at oestrus, or if oestrus was not observed a second PGF2α injection was given (Day 13) and AI at observed oestrus. Progesterone was measured in serum at Day 0 and in milk at AI. Pregnancy diagnosis was performed by measuring bovine Pregnancy Specific Protein B (bPSPB) (Day 50 + 3) and confirmed by ultrasonography when the result was doubtful.In expt. 1, farmers observed 47/101 (46.9 %) of group 1 cows in oestrus, 33/91 on Day 10 and 10 before Day 10. The progesterone concentrations were compatible with oestrus in 69/86 (80%) of cows on Day 10. In group 2, 36/83 (43.4 %) of cows were inseminated after the first PGF2α injection. After the second PGF2 α, only 29/43 (67 %) of cows had a low progesterone concentration at AI. The pregnancy rates were 36.1% and 32.5 % for groups 1 and 2, respectively. In expt. 2, oestrus was observed in 31/93 (33.7 %) of group 1 cows. In group 2, 51/75 (66 %) of cows were inseminated after the first injection of PGF2α, 13/75 (17.3 %) after the second and 11/75 (14.7 %) were not seen in oestrus. Pregnancy rates were 53.7% and 53.3% in groups 1 and 2, respectively. In conclusion, it is recommended that suboestrus be treated with PGF2α followed by AI at observed oestrus when oestrus detection is good while, the use of GnRH + PGF2α + GnRH is recommended when oestrus detection is poor.
The effect of changes in feed intake around the time of insemination on systemic progesterone and embryo development and survival in cattle.
Authors: Dunne L.D. , Diskin M.G. , Boland M.P. , O'Farrell K.J. , Sreenan J.M. 
Published: May 2019

AbstractEarly embryo loss is the major cause of reproductive failure in cattle. The objective of this study was to investigate the effect of changes in feed intake around the time of insemination on systemic progesterone and on embryo development and survival and in cattle. Nutrition treatments were designed to provide 0.8 times (Low, L) or twice (High, H) maintenance energy requirements. Oestrus was synchronised in heifers (n=314) using two injections of prostaglandin (PG; 50 μg Cloprostenol, Estrumate) administered 10 days apart. On the day of oestrus following the first PG injection, heifers were randomly allocated to L or H (pre-AI). At the oestrus following the second PG injection, heifers were inseminated with semen from the same Limousin bull and on the following day were randomly allocated to either L or H until embryo recovery at day 8 (n=25), 14 (n=57) or 16 (n=71) or pregnancy diagnosis at day 30 (n=161). Hence there were four nutrition treatments; L-L, L-H, H-H and H-L. There was no significant difference in embryo survival rate determined at day 14, 16 or 30 and so the data were combined for analysis. Overall embryo survival rate was significantly lower (P<0.001) in H-L (0.37) than L-L (0.70), L-H (0.71; P<0.001) or H-H (0.68; P<0.01) treatment groups. Nutrition treatment did not affect systemic progesterone measured on days 4, 5, 6 or 7 of the pre- or post-AI oestrous cycle. The total cell number of 8-day-old blastocysts was not significantly affected by nutrition treatment neither was the length, diameter or estimated total protein content of 14-day-old embryos. Reducing energy intake immediately after AI reduced embryo survival rate but there was no evidence that this effect was mediated through changes in systemic progesterone.
Early embryo development in nuclear transfer clones derived from somatic cells of a high genetic merit dairy cow
Authors: McMillan W.H. , Wells D.N. , Peterson AJ. , Donnison M.J. 
Published: May 2019

AbstractThe reported post transfer survival rate to term of cloned embryos derived from both undifferentiated blastomeres and differentiated foetal and adult cells is very low (typically less than 20%). Furthermore, it is acknowledged that there are many technical issues that remain to be resolved to improve the efficiency of nuclear transfer before the technique will find widespread, practical and cost-effective use in multiplying valuable livestock in agriculture. The purpose of this study was to compare early embryo morphology following embryo transfer of nuclear transfer blastocysts derived from somatic cells of an adult Friesian cow with that of standard in vitro-produced embryos. In the present study, 150 embryos were transferred in bulk (i.e., 15, 20 or 25 per recipient) to the ipsilateral uterine horn of 8 recipients using standard non-surgical embryo transfer procedures. Embryos were then recovered following necropsy on either Day 14 or Day 23 of pregnancy and developmental traits described. Embryo recovery and elongation rates were similar on Day 14 of pregnancy (Table 1), although cloned conceptuses were longer and narrower (P<0.05). Embryo recovery and viability rates by Day 23 were similar, although many of the developmental traits appeared more advanced in cloned conceptuses. (Table 1). Allantois development was different because of greater widths and the presence of ‘spurs’ that were not observed with in vitro-produced embryos. We conclude that apparently abnormal conceptus development occurs by about 3 weeks of pregnancy following nuclear transfer, but that embryo survival is not compromised at this early stage of development.
Investigation of infertility problems in dairy herds
Authors: McCaughey W.J. , McCoy M. , Mayne C.S. , Verner M. , Lennox S.D. , Catney D.C. , Wylie A.R.G. , Kennedy B , Gordon F.J. 
Published: May 2019

Abstract.Ten dairy herds reporting acute fertility problems were investigated by analysing records and cows, metabolic profiles, tests for infectious agents and milk hormone assays. The main problems were : heat detection (2), endometritis (3) and inadequate nutrition (5). In one herd no cause has yet been identified. On all farms the problem had been present from the start of the breeding period. Management changes, delayed analysis of herd records and over-estimation of forage nutritive value were underlying problems. A diagnostic analysis/decision process to highlight problems early is essential to minimise loss.
Reproduction, mastitis, and body condition scores among spring and fall calving dairy cows in pasture or confinement feeding systems
Authors: Washburn S. P. , White S. L. , Green J. T. , Benson G. A. 
Published: May 2019

AbstractDairy cows in confinement and pasture-based feeding systems were compared across 4 spring-calving and 3 fall-calving replicates for differences in reproduction, mastitis, and body condition scores. Each feeding system and replicate included both Jersey and Holstein cows. Cows in confinement were fed a total mixed ration with maize silage as the base forage along with a variety of concentrates. Cows on pasture were routinely supplemented with concentrates and were provided baled grass and/or legume silage when pastures were limiting. Breeding periods were for 75 days in spring or fall. Reproductive performance did not differ significantly due to feeding system but Jerseys had higher conception rates (59.6 vs. 49.5%) and overall pregnancy rates (78.0 vs. 57.9%) than Holsteins. Cows in confinement had significantly higher rates of clinical mastitis and culling for mastitis than cows on pasture. Within both feeding systems, Jerseys had less mastitis than Holsteins. Average body condition scores were higher for confinement cows than pasture cows except for one replicate. Jerseys maintained higher average body condition scores than Holsteins in all but one replicate. In summary, pastured cows produced less milk and had less mastitis but lower body condition scores than confinement cows. Holsteins produced more milk but were less likely to rebreed, had more mastitis, higher culling rates, and maintained lower body condition scores than Jerseys.
Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis
Authors: Venditti Massimo , Aniello Francesco , Santillo Alessandra , Minucci Sergio 
Published: May 2019

SummaryProlyl endopeptidase (PREP) is a post-proline cleaving enzyme. It is involved in the regulation of multiple inositol polyphosphate phosphatase activity implicated in the pathway of inositol 1,4,5-trisphosphate, resulting in the modulation of cytosolic Ca2+ levels. Besides its peptidase activity, PREP was identified as a binding partner of tubulin, suggesting that it may participate in microtubule-associate processes. In this paper, we evaluated the expression of PREP mRNA and protein by polymerase chain reaction and western blot analyses and its co-localization with tubulin by immunofluorescence in adult mouse seminal vesicles. We showed that both proteins are cytoplasmic: tubulin is localized at the apical half part of the cell, while PREP has a more diffuse localization, showing a prominent distribution at the apical cytoplasm. These findings support our hypothesis of a specific role for PREP in cytoskeletal rearrangement that occurs during the exocytosis of secretory vesicles, and in particular its association with tubulin filaments. Moreover, it may regulate Ca2+ levels, and promote the final step of vesicular exocytosis, namely the fusion of the vesicles with the plasma membrane. These results strongly suggest that there is a pivotal role for PREP in vesicle exocytosis, as well as in the physiology of mouse seminal vesicles.
Cognitive Reserve Capacity: Exploring and Validating a Theoretical Model in Healthy Ageing
Authors: McGarrigle Lisa , Irving Kate , van Boxtel Martin P.J. , Boran Lorraine 
Published: May 2019

AbstractObjective:Cognitive reserve (CR) capacity can be viewed as the maximum processing potential of neural systems that support adaptive cognitive performance in age-related cognitive decline. CR is a complex construct that can only be measured indirectly. Proxy measures (e.g., psychosocial/lifestyle variables) are traditionally used to reflect CR. However, strong relationships have been observed between these measures and cognitive functions (e.g., executive function [EF], processing resources [PR], fluid/crystallized abilities); therefore, the organizational structure of indicators implicated in CR remains unclear. The objective of this study was to test a hypothetical, theoretical model of CR capacity that includes both traditional CR proxy indicators and measures of cognitive function [Satz et al. (2011).Journal of Clinical and Experimental Neuropsychology,33(1), 121–130], which remain, as yet, untested.Method:Construct validity of the model was investigated in healthy older adults through exploratory and confirmatory factor analysis (EFA and CFA) using data from the Maastricht Ageing Study (MAAS). A secondary CFA was conducted to validate the model using data from the Irish Longitudinal Study on Ageing (TILDA).Results:EFA and CFA in MAAS established a two-factor model comprising EF/PR and cumulative cognitive enrichment (CCE), which was further validated in a secondary analysis in TILDA. Convergent and discriminant validity was supported in MAAS (range ofR2= .228–.635; factor correlation confidence interval (CI) = .622, .740) and TILDA (range ofR2= .172–.899; factor correlation CI = .559, .624).Conclusions:A dual model of CR elucidated the relationships between hypothesized indicators of CR capacity and revealed a two-factor structure suggesting that both control (EF/PR) and representational processes (CCE) are involved in CR capacity.