bluuebunny/crossref_metadata_2025_split huggingface dataset:
A recent history of nitroxyl chemistry, pharmacology and therapeutic potential
Authors: Fukuto Jon M 
Published: June 2018

Due to the excitement surrounding the discovery of NO as an endogenously generated signalling molecule, a number of other nitrogen oxides were also investigated as possible physiological mediators. Among these was nitroxyl (HNO). Over the past 25 years or so, a significant amount of work by this laboratory and many others has disclosed that HNO possesses unique chemical properties and important pharmacological utility. Indeed, the pharmacological potential for HNO as a treatment for heart failure, among other uses, has garnered this curious molecule a considerable amount of recent attention. This review summarizes the events that led to this recent attention as well as poses important questions that are still to be answered with regards to understanding the chemistry and biology of HNO.Linked ArticlesThis article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc
Effects of acute exercise on drug craving, self‐esteem, mood and affect in adults with poly‐substance dependence: Feasibility and preliminary findings
Authors: Ellingsen Maren Mikkelsen , Johannesen Sunniva Launes , Martinsen Egil W. , Hallgren Mats 
Published: June 2018

AbstractIntroduction and AimsNovel treatments for substance use disorders are needed. Acute bouts of exercise can improve mood states in non‐clinical populations, but effects in those with poly‐substance dependence are understudied. We examined the feasibility and short‐term effects of three types of exercise on drug cravings, self‐esteem, mood and positive/negative affect in nine poly‐drug‐dependent inpatients.Design and MethodsUsing a cross‐over design, changes in the four study outcomes were assessed immediately before exercise and on four separate occasions post‐exercise (immediately after, then at 1, 2 and 4 h post‐exercise) enabling patterns of change over time (analysis of covariance) to be observed.ResultsParticipants were willing and able to engage in different non‐laboratory based exercises. Football was associated with non‐significant short‐term reductions in drug cravings. A similar trend was seen for circuit‐training, but not walking. Football and circuit‐training were associated with brief improvements in mood and positive/negative affect. No adverse events were reported.Discussion and ConclusionsFootball, circuit training and walking are feasible therapeutic activities for inpatients with poly‐substance dependence. Controlled trials are needed to determine the long‐term effects of these activities.
Dulaglutide decreases plasma aminotransferases in people with Type 2 diabetes in a pattern consistent with liver fat reduction: a post hoc analysis of the AWARD programme
Authors: Cusi K. , Sattar N. , García‐Pérez L.‐E. , Pavo I. , Yu M. , Robertson K. E. , Karanikas C. A. , Haupt A. 
Published: June 2018

AbstractAimsTo evaluate the effects of dulaglutide vs placebo on liver and glycaemic/metabolic measurements in a population with Type 2 diabetes and in a subgroup with non‐alcoholic fatty liver/non‐alcoholic steatohepatitis.MethodsA total of 1499 participants from AWARD‐1, AWARD‐5, AWARD‐8 and AWARD‐9 clinical trials were included in this analysis (dulaglutide 1.5 mg, n=971 and placebo, n=528). Thresholds of alanine aminotransferase levels ≥30 IU/l in men and ≥19 IU/l in women were used to determine the subgroup who had non‐alcoholic fatty liver/non‐alcoholic steatohepatitis. Objectives included changes from baseline to 6 months in: (1) alanine aminotransferase, aspartate transaminase and gamma‐glutamyl transpeptidase levels in the overall population and (2) alanine aminotransferase, aspartate transaminase, gamma‐glutamyl transpeptidase and glycaemic/metabolic measurements (e.g. HbA1c, fasting serum glucose, body weight, lipids and homeostatic model assessment) in the non‐alcoholic fatty liver/non‐alcoholic steatohepatitis subgroup.ResultsIn the overall population at 6 months, dulaglutide significantly reduced alanine aminotransferase, aspartate transaminase and gamma‐glutamyl transpeptidase levels vs placebo [least squares mean treatment differences: –1.7 IU/l (95% CI –2.8, –0.6), P=0.003; –1.1 IU/l (95% CI –2.1, –0.1), P=0.037; –6.6 IU/l (95% CI –12.4, –0.8), P=0.025, respectively]. In the subgroup with non‐alcoholic fatty liver/non‐alcoholic steatohepatitis (alanine aminotransferase levels greater than or equal to the upper limit of normal), mean baseline liver enzyme values were 38.0 IU/l, 27.8 IU/l and 43.9 IU/l for alanine aminotransferase, aspartate transaminase and gamma‐glutamyl transpeptidase, respectively. In this population, more pronounced reductions from baseline in alanine aminotransferase were observed with dulaglutide vs placebo (–8.8 IU/l vs –6.7 IU/l). In the subgroup of people with alanine aminotransferase levels less than the upper limit of normal, changes from baseline in alanine aminotransferase did not significantly differ between treatment groups (0.0 IU/l vs 0.7 IU/l).ConclusionsOnce‐weekly dulaglutide improved alanine aminotransferase, aspartate transaminase and gamma‐glutamyl transpeptidase levels compared with placebo in a pattern consistent with liver fat reductions. Our results add further weight to the notion that glucagon‐like peptide‐1 receptor agonists may provide benefit in lowering liver fat in addition to their other metabolic actions.
Morbidity of teeth in mandibular fracture lines—A retrospective study
Authors: Kheirallah Mouetaz , Ozzo Sameer 
Published: June 2018

AbstractBackground/AimTeeth in mandibular fracture lines are common in maxillofacial trauma, but their retention or extraction is a matter of controversy. The aim of this study was to determine the factors related to retaining or extracting teeth situated in mandibular fracture lines and to decide the best treatment option.MethodsThe study included 115 patients with a single mandibular fracture that had a tooth in the line of fracture. All patients were evaluated for complications and pulp status. Patient distribution was analysed according to the complications that occurred. Statistical analysis was performed using SPSS 13.0 software.ResultsThere were significant effects of tooth type and tooth location on the occurrence of complications. There were no significant differences in the occurrence of complications between the retained teeth group and the extracted teeth group irrespective of age and gender in adult patients. There were significant differences in treatment procedures between the retained teeth group and the extracted teeth group.ConclusionMandibular anterior teeth involved in the fracture line should be retained, while in the mandibular angle area, they should be extracted because retaining teeth in this region increases the predictability of complications. There is no role of pulp testing in the assessment of pulp status, but root canal treatment of retained teeth helps to reduce the occurrence of complications.
Quality of life in survivors of hematological malignancies stratified by cancer type, time since diagnosis and stem cell transplantation
Authors: Esser Peter , Kuba Katharina , Mehnert Anja , Johansen Christoffer , Hinz Andreas , Lordick Florian , Götze Heide 
Published: June 2018

AbstractObjectivesQuality of life (QoL) has become an important tool to guide decision making in oncology. Given the heterogeneity among hematological cancer survivors, however, clinicians need comparative data across different subsets.MethodsThis study recruited survivors of hematological malignancies (≥2.5 years after diagnosis) from 2 German cancer registries. QoL was assessed with the EORTC QLQ‐C30. The sample was stratified by cancer type, time since diagnosis, treatment with stem cell transplantation (SCT) and type of SCT. First, levels of QoL were compared across subsamples when controlling for several covariates. Second, we contrasted subsamples with gender‐ and age‐matched population controls obtained from the general population.ResultsOf 2001 survivors contacted by mail, 922 (46%) participated in the study. QoL did not significantly differ between the subsamples. All subsamples scored significantly lower in functioning and significantly higher in symptom burden compared to population controls (all P < .001). Almost all of these group effects reached clinically meaningful sizes (Cohen′s d ≥ .5). Group differences in global health/QoL were mostly non‐significant.ConclusionsHematological cancer survivors are associated with practically relevant impairments irrespective of differences in central medical characteristics. Nevertheless, survivors seem to evaluate their overall situation as relatively well.
Biodiversity effects on ecosystem functioning respond unimodally to environmental stress
Authors: Baert Jan M. , Eisenhauer Nico , Janssen Colin R. , De Laender Frederik 
Published: June 2018

AbstractUnderstanding how biodiversity (B) affects ecosystem functioning (EF) is essential for assessing the consequences of ongoing biodiversity changes. An increasing number of studies, however, show that environmental conditions affect the shape of BEF relationships. Here, we first use a game‐theoretic community model to reveal that a unimodal response of the BEF slope can be expected along environmental stress gradients, but also how the ecological mechanisms underlying this response may vary depending on how stress affects species interactions. Next, we analysed a global dataset of 44 experiments that crossed biodiversity with environmental conditions. Confirming our main model prediction, the effect of biodiversity on ecosystem functioning tends to be greater at intermediate levels of environmental stress, but varies among studies corresponding to differences in stress‐effects on species interactions. Together, these results suggest that increases in stress from ongoing global environmental changes may amplify the consequences of biodiversity changes.
Rapid evolution of generalized resistance mechanisms can constrain the efficacy of phage–antibiotic treatments
Authors: Moulton‐Brown Claire E. , Friman Ville‐Petri 
Published: June 2018

AbstractAntimicrobial resistance has been estimated to be responsible for over 700,000 deaths per year; therefore, new antimicrobial therapies are urgently needed. One way to increase the efficiency of antibiotics is to use them in combination with bacteria‐specific parasitic viruses, phages, which have been shown to exert additive or synergistic effects in controlling bacteria. However, it is still unclear to what extent these combinatory effects are limited by rapid evolution of resistance, especially when the pathogen grows as biofilm on surfaces typical for many persistent and chronic infections. To study this, we used a microcosm system, where genetically isogenic populations of Pseudomonas aeruginosa PAO1 bacterial pathogen were exposed to a phage 14/1, gentamycin or a combination of them both in a spatially structured environment. We found that even though antibiotic and phage–antibiotic treatments were equally effective at controlling bacteria in the beginning of the experiment, combination treatment rapidly lost its efficacy in both planktonic and biofilm populations. In a mechanistic manner, this was due to rapid resistance evolution: While both antibiotic and phage selected for increased resistance on their own, phage selection correlated positively with increase in antibiotic resistance, while biofilm growth, which provided generalized resistance mechanism, was favoured most in the combination treatment. Only relatively small cost of resistance and weak evidence for coevolutionary dynamics were observed. Together, these results suggest that spatial heterogeneity can promote rapid evolution of generalized resistance mechanisms without corresponding increase in phage infectivity, which could potentially limit the effectiveness of phage–antibiotic treatments in the evolutionary timescale.
Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis
Authors: Nguyen Quang Huy , Contamin Lucie , Nguyen Thi Van Anh , Bañuls Anne‐Laure 
Published: June 2018

AbstractAt present, the successful transmission of drug‐resistant Mycobacterium tuberculosis, including multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberculosis drug resistance is acquired mainly through mutations in specific drug resistance‐associated genes. The panel of mutations is highly diverse, but depends on the affected gene and M. tuberculosis genetic background. The variety of genetic profiles observed in drug‐resistant clinical isolates underlines different evolutionary trajectories towards multiple drug resistance, although some mutation patterns are prominent. This review discusses the intrinsic processes that may influence drug resistance evolution in M. tuberculosis, such as mutation rate, drug resistance‐associated mutations, fitness cost, compensatory mutations and epistasis. This knowledge should help to better predict the risk of emergence of highly resistant M. tuberculosis strains and to develop new tools and strategies to limit the development and spread of MDR and XDR strains.
Pathological risk factors for higher clinical stage in testicular seminomas
Authors: Trevino Karen E , Esmaeili‐Shandiz Alaleh , Saeed Omer , Xu Huiping , Ulbright Thomas M , Idrees Muhammad T 
Published: June 2018

SummaryAimsTesticular seminomas require accurate staging for effective management. Twenty per cent are metastatic at presentation, while 80% are clinical stage I, requiring only orchiectomy and surveillance. Tumour size, rete testis invasion, hilar soft tissue invasion and lymphovascular invasion have been shown to incur a higher risk of metastasis and recurrence in clinical stage I seminomas, with little congruence between studies.Methods and resultsWe reviewed 211 cases of testicular seminomas and recorded patient age, tumour size, lymphovascular invasion and rete testis, hilar soft tissue, epididymis, spermatic cord, tunica albuginea and tunica vaginalis involvement. A univariate and multivariate analysis was performed comparing clinical stage I to advanced clinical stage patients (stages II and III) in reference to these factors. We found that tumour size (P = 0.02), vascular invasion (P = 0.02) and invasion of rete testis stroma (P = 0.01), epididymis (P = 0.02), spermatic cord (P = 0.047) and hilar soft tissue (P = 0.04) were predictors of higher clinical stage at the univariate level. However, multivariate analysis showed that only tumour size and vascular invasion remained significant (P = 0.008 and 0.032, respectively). A tumour size of 4 cm was the cut‐off size found to be significant.ConclusionsTumour size and vascular invasion are the strongest predictors of higher clinical stage in testicular seminomas. Our univariate data suggest that rete testis and hilar soft tissue invasion relate to higher clinical stage. However, neither of these factors were found to be independent risk factors at multivariate analysis. Therefore, this study supports tumour upstaging based only upon size and vascular invasion.
PHILOSOPHICAL REFLECTIONS ON THE WAYS OF MEMORY AND HISTORY
Authors: Hutton Patrick H. 
Published: June 2018

ABSTRACTPhilosopher Jeffrey Barash seeks to clarify the concept of collective memory, which has taken on wide‐ranging meanings in contemporary scholarship. Returning to the original insight of sociologist Maurice Halbwachs during the 1920s, he grounds the concept in the living social memory of the present, whose sphere is widened by its capacity to draw upon a past beyond its ken through the symbolization of its remembrance. He offers two preliminary propositions: first, there is a history to the way philosophers have contextualized collective memory through the ages; second, there is a politics in the transmission of collective memory, highly visible in the uses of memory by mass media in the contemporary age. He builds his argument around four interrelated interpretations concerning: the ever more circumscribed role attributed to collective memory in the passage from antiquity into modernity; the dependence of collective memory upon living memory; the rising power of media to mold collective memory to present purposes; and historical understanding vis‐à‐vis evocation of collective memory as oppositional ways of accessing the past. I close with commentary that places Barash's philosophical interpretation within the context of contemporary historiographical practice, with particular attention to the scholarship of French historian Pierre Nora on the French national memory, and that of German scholars Jan and Aleida Assmann on the preservation and transmission of memorable cultural legacies.
HISTORY TO THE MAX
Authors: Carr David 
Published: June 2018

ABSTRACTSteven G. Smith advocates a maximal approach to history by both historians and theorists of history, maintaining that a commitment to fullness or totality should always serve as an ideal. In my review, I try to explain what the author means by this ideal, and consider how practical such an ideal can be. He further maintains that history is mostly about shared action, and is itself an instance of shared action. I have certain reservations about this notion, though I think Smith's book deserves credit for calling attention to it.
Cinnamic acid derivatives in cosmetics: current use and future prospects
Authors: Gunia‐Krzyżak A. , Słoczyńska K. , Popiół J. , Koczurkiewicz P. , Marona H. , Pękala E. 
Published: June 2018

AbstractCinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring and synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. A perfuming function is typical of many derivatives of cinnamaldehyde, cinnamyl alcohol, dihydrocinnamyl alcohol and cinnamic acid itself; these substances are commonly used in cosmetics all over the world. Some of them show allergic and photoallergic potential, resulting in restrictions in maximum concentrations and/or a requirement to indicate the presence of some substances in the list of ingredients when their concentrations exceed certain fixed values in a cosmetic product. Another important function of cinnamic acid derivatives in cosmetics is UV protection. Ester derivatives such as ethylhexyl methoxycinnamate (octinoxate), isoamyl p‐methoxycinnamte (amiloxiate), octocrylene and cinoxate are used in cosmetics all over the world as UV filters. However, their maximum concentrations in cosmetic products are restricted due to their adverse effects, which include contact and a photocontact allergies, phototoxic contact dermatitis, contact dermatitis, estrogenic modulation and generation of reactive oxygen species. Other rarely utilized functions of cinnamic acid derivatives are as an antioxidant, in skin conditioning, hair conditioning, as a tonic and in antimicrobial activities. Moreover, some currently investigated natural and synthetic derivatives of cinnamic acid have shown skin lightening and anti‐ageing properties. Some of them may become new cosmetic ingredients in the future. In particular, 4‐hydroxycinnamic acid, which is currently indexed as a skin‐conditioning cosmetics ingredient, has been widely tested in vitro and in vivo as a new drug candidate for the treatment of hyperpigmentation.
Shaping ability of BioRace, ProTaper NEXT and Genius nickel‐titanium instruments in curved canals of mandibular molars: a MicroCT study
Authors: Drukteinis S. , Peciuliene V. , Dummer P. M. H. , Hupp J. 
Published: June 2018

AbstractAimTo evaluate and compare the canal shaping ability of BioRace, ProTaper NEXT and Genius engine‐driven nickel‐titanium (NiTi) file systems in extracted mandibular first molars using micro‐computed tomography (MCT).MethodologySixty mesial root canals of mandibular first molars were randomly divided into three equal groups, according to the instrument system used for root canal preparation (n = 20): BioRace (BR), ProTaper NEXT (PTN) or Genius (GN). Root canals were prepared to the full WL using a crown‐down technique up to size 35, .04 taper instruments for BR and GN groups and size 30, .07 taper instruments for the PTN group. MCT was used to scan the specimens before and after canal instrumentation. Changes in dentine volume, the percentage of uninstrumented canal surface and degree of canal transportation were evaluated in the coronal, middle and apical thirds of canals. Data were analysed statistically using one‐way analysis of variance and Tuckey's post hoc tests with the significance level set at 5%.ResultsThere were no significant differences between the three groups in the terms of dentine removed after preparation and determination of the root canal volume, or percentage of uninstrumented canal surface (P > 0.05). No significant differences were found between the systems for canal transportation in any canal third (P > 0.05).ConclusionsThe shaping ability of the BR, PTN and GN NiTi file systems was equally effective. All instrumentation systems prepared curved root canal systems with no evidence of undesirable changes in 3D parameters or significant shaping errors.
THE DYNAMICS OF BERTRAND PRICE COMPETITION WITH COST‐REDUCING INVESTMENTS
Authors: Iskhakov Fedor , Rust John , Schjerning Bertel 
Published: June 2018

AbstractWe extend the classic Bertrand duopoly model of price competition to a dynamic setting where competing duopolists invest in a stochastically improving production technology to “leapfrog” their rival and attain temporary low‐cost leadership. We find a huge multiplicity of Markov‐perfect equilibria (MPE) and show that when firms move simultaneously the set of all MPE payoffs is a triangle that includes monopoly payoffs and a symmetric zero mixed strategy payoff. When firms move asynchronously, the set of MPE payoffs is strictly within this triangle, but there still is a vast multiplicity of MPE, most of which involve leapfrogging.
MULTILATERAL TRADE BARGAINING AND DOMINANT STRATEGIES
Authors: Bagwell Kyle , Staiger Robert W. 
Published: June 2018

AbstractMotivated by General Agreement on Tariffs and Trade bargaining behavior and renegotiation rules, we construct a three‐country, two‐good general‐equilibrium model of trade and examine multilateral tariff bargaining under the constraints of nondiscrimination and multilateral reciprocity. For a general representation of government preferences, we identify the bargaining outcomes that can be achieved using dominant strategy proposals for all countries. In our analysis, dominant strategy outcomes emerge when tariff proposals are followed by multilateral rebalancing. The resulting bargaining outcome is efficient relative to government preferences if and only if the initial tariff vector positions the initial world price at its “politically optimal” level.
ECONOMIC ANALYSIS OF SOCIAL SECURITY SURVIVORS INSURANCE
Authors: Li Yue 
Published: June 2018

AbstractThis article develops a heterogeneous agents model to analyze the effects of Social Security survivors insurance. The model features a negative mortality–income gradient, asymmetric information of individual mortality rates, and a warm‐glow bequest motive that varies by age and family structure. The model matches life‐cycle changes in life insurance coverage and generates advantageous selection in the insurance market. For male agents, reducing survivors benefits for dependent children generates welfare losses, whereas reducing survivors benefits for aged spouses produces welfare gains. The opposing welfare results are explained by differences in the timing of benefits and in the funding cost.