bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHITOSAN NANOPARTICLES AS DRUG DELIVERY SYSTEM FOR CEPHALEXIN AND ITS ANTIMICROBIAL ACTIVITY AGAINST MULTIIDRUG RESISTENT BACTERIA
Authors: Elassal Mona , El-Manofy Nagwan 
Published: July 2019

Objective: The evolution of antimicrobial resistance is a universal obstacle that necessities the innovation of more effective and safe antimicrobial alternatives with synergistic properties. The purpose of this study was to investigate the possible improvement of cephalexin antimicrobial treatments by loading into chitosan-based nanoparticles, then evaluate their antibacterial and antibiofilm activities as well as determination of its cytotoxicity.
Methods: Chitosan nanoparticles (CSNPs) were prepared by ionic gelation method. Parameters were studied to optimize the particle size of CSNPs including pH, stirring rate, homogenization and ultra-sonication time. Size was measured by transmission electron microscope (TEM) and Zeta sizer, morphology seen by scanning electron microscope (SEM). Entrapment efficiency, drug loading and drug content were calculated. Stability of both plain and loaded chitosan Nano-carriers, Drug release and Kinetics also compatibilities were studied. Antimicrobial activity of CSNPs and cephalexin loaded CSNPs were evaluated against 4 Gram-positive and 4 Gram-negative standard and clinical isolates by microdilution method, also assessment of antibiofilm activity of both formulas was investigated against two biofilm producers clinical isolates by tube assay in addition to determination of their cytotoxicity by MTT(3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
Results: Chitosan nanoparticles and its loaded antibiotics proved compatible combination with small Zeta size, suitable Zeta potential, maximum EE% and drug-loading capacity, sustained controlled release properties followed diffusion kinetic model and six month stability studies. Cephalexin loaded CSNPs showed better antimicrobial activity than plain CSNPs. Synergistic effects were found against S. aureus (ATCC 25923), B. subtilis (ATCC 9372), S. epidermidis, E. faecalis, P. aeruginosa (ATCC 29853) in addition to two carbapenem resistant isolates k. pneumoniae and E. coli. Also cephalexin loaded CSNPs exhibited antibiofilm activity against E. faecalis clinical isolate. Even though, cephalexin loaded CSNPs exhibited significant antibacterial activity, it showed less toxicity against mammalian cells, it had IC50 equal to 231.893 and did not exhibit any cytotoxicity against the WI-38 fibroblast cells at concentration 23.4 µg/ml.
Conclusion: Cephalexin loaded CSNPs possessed good stability and sustained release effect in addition to its antimicrobial, antibiofilm activities and reduced cytotoxicity.
Percepción de profesionales en administración sobre algunas variables organizacionales como potenciales generadores de estrés laboral
Authors: Quirós Morales Diego José 
Published: July 2019

La incapacidad de respuesta ante demandas organizacionales producto de su ejercicio puede derivar en factores de riesgo psicosocialtales como el estrés. El presente estudio tuvo como objetivo la valoración de la percepción de profesionales de la administración y los negocios sobre algunas variables organizacionales como potenciales generadores de estrés laboral. Se diseñó y aplicó el Cuestionario para la Valoración de Factores Generadores de Estrés en las Organizaciones (CUVEO). El instrumento fue aplicado en una muestra de 784 sujetos masculinos y femeninos entre los 19 y los 70 años de edad, la mayoría con universidad completa. Los datos fueron analizados mediante el software SPSS. En términos generales, la valoración de la percepción de los participantes sobre las variables indagadas como potenciales generadores de estrés ha resultado en un nivel medio, por lo que refiere a la importancia de la atención de su alcance.
Marco metodológico para aplicar un modelo de gestión de riesgos financieros en la UNED
Authors: Arce Solano Jorge Luis 
Published: July 2019

Este artículo expone resultados de una investigación realizada en el 2013. Propone el Marco Técnico de Referencia para la construcción de un Modelo de Gestión de Riesgos Financieros aplicado a una institución pública universitaria. Se analizan aspectos teóricos de la Gestión de Riesgos, muestra la propuesta del Estándar Australiano de Administración del Riesgo AS/NZS4360:1999, que revela una serie de definiciones para comprender su aplicación en las organizaciones. La etapa metodológica consta de un objetivo central y tres objetivos específicos que exponen la ruta a seguir para construir el modelo de gestión. Se analizaron las características utilizadas para gestionar el riesgo en las empresas; dentro del análisis planteado, las acciones para determinar probabilidades (grado de ocurrencia del riesgo) e impactos (consecuencias que pueden generar el riesgo), el tratamiento que identifica técnicas y alternativas para la mitigación del riesgo y finalmente su seguimiento y monitoreo durante toda la gestión del riesgo. A partir de ahí, se propone el modelo a implementar.
Risk factors for development of myocardial infarction in women with preserved reproductive function
Authors: Seliverstova Daria V. 
Published: July 2019

Aim. Identification of risk factors (RF) for myocardial infarction (MI) among women with preserved menstrual function.
Material and Methods. 121 Female patients under 55 years of age, who were hospitalized with MI in the cardiology departments of Ryazan in the period 2010-2016, were studied. All patients were divided into 2 groups. The first group included women with a regular menstrual cycle without menopausal symptoms (n=60, mean age 48.0±6.1 years). The second group consisted of postmenopausal women (n=61, mean age 49.8±4.3 years). Of a cohort of studied women a group of women was isolated (n=18 from group 1 and n=15 from group 2) who, during hospitalization with MI in 2015-2016, filled in questionnaires on nutrition and physical activity.
Results. In women of group 1 such risk factors as burdened heredity for cardiovascular diseases (58.3%, p=0.02) and smoking (46.7%, p=0.03) were more common than in women of group 2. Only women of group 1 took oral contraceptives before the onset of MI (15%, p=0.005). The most common RFs were: arterial hypertension (˃80% of patients in both groups; overweight and obesity (78.3% of women from group 1 and 83.6% from group 2); type 2 diabetes mellitus (23.3% in group 1 and 24.6% in group 2). According to the results of the questionnaire on food habits, insufficient use of fruit and vegetables was detected among all patients of both groups. In analysis of the results of the International Physical Activity Questionnaire (IPAQ), 72.2% of patients in group 1 experienced insufficient physical activity, and 53.3% of patients in group 2 showed pronounced hypodynamia. Biochemical analysis of blood revealed increased average levels of total cholesterol, low-density lipoproteins and triglycerides, with high-density lipoproteins within the normal range in both groups.
Conclusion. The most common risk factors for myocardial infarction in women with preserved menstrual function in comparison with postmenopausal women were: positive heredity for cardiovascular diseases, smoking and taking oral contraceptives. Besides, a wide spread of arterial hypertension, dyslipidemia and diabetes mellitus, overweight and obesity, low physical activity and lack of fruit and vegetables in the diet of women in both groups should be noted.
Computer model for identification of groups of risk for malignant neoplasms of fe-male sex sphere using questionnaire
Authors: Malashenkо Viktor N. , Ershov Alexey M. , Ershova Yulia V. 
Published: July 2019

Aim. To identify predictors of malignant neoplasms (MN) of female sex sphere, to evaluate their sensitivity and specificity, to calculate prognostic coefficient (PC) and to create a computer program on its basis for automated processing of questionnaire data for arrangement of groups of risk for regular medical check-ups through the Internet (without participation of a physician) or on computers of women’s health clinics.
Materials and Methods. The work was performed in two steps. The 1st step was an open questioning survey of 226 women, divided into 2 groups: the 1st group included women with MN of the sex sphere (n=125); the 2nd group included conventionally healthy women. The questionnaire included 82 positions: 19 open questions and 63 questions with a choice of an answer. The second stage consisted in a «blind» questioning of 120 women who visited a women’s health clinic. The questionnaire included 18 earlier identified predictors. A multifactor model was developed on the basis of questionnaire data and also using the material of medical histories and of histological examinations.
Results. Using ROC-analysis of the questionnaire data, 18 significant predictors of MN of female sex sphere were identified. On their basis a formula was derived for calculation of PC for the risk of development of MN of female sex sphere with 72.8% sensitivity and 95% specificity, which was used for creation of a computer model for automated processing of questionnaire data with the aim of identification of groups of risks and for medical check-ups without participation of physicians through Internet sites of hospitals. Then, in result of closed questioning of women (n=120) by 18 predictors, 70 women got into a group of risk, in 47 of them (67%) MN of sex sphere were identified, 50 fell into a group of conventionally healthy women, of them 45 (90%) were healthy, and 5 (10%) had MN.
Conclusions. 1) Multifactor statistical ROC-analysis of 82 questions and answers permitted to identify 18 predictors of MN of female sex sphere which can be used to scientifically substantiate identification of groups of risk for organization of regular prophylactic measures. 2) The conducted work permitted to create a computer program for automated processing of questionnaires for formation of groups of risk and for regular medical check-ups. We believe that introduction of questionnaire screening through the Internet with subsequent computer processing of the results without participation of physicians with permit to increase the coverage of women’s population of the Russian Federation with prophylactic measures against MN of the female sex sphere and to provide more time for receipt of primary patients, to simplify the work for creation of data base, and to increase the oncological alertness of women’s population.
PENGEMBANGAN VIDEO PEMBELAJARAN TEKNIK MENJAHIT BUSANA PADA MATA KULIAH BUSANA DASAR DI IKK FPP UNP
Authors: Fitria Reni , Nazar Ernawati , Nelmira Weni , Sahara Nita 
Published: July 2019

AbstrakArtikel ini membahas Pengembangan Video Pembelajaran Teknik Menjahit Busana Pada Mata Kuliah Busana Dasar yang bersifat valid dan praktis. Pelaksanaan perkuliahan ini sangat memerlukan penalaran yang cukup tinggi dalam memahami setiap langkah pada proses menjahit pakaian, sehingga dibutuhkan metode khusus untuk dapat mendeskripsikan proses menjahit secara nyata kepada mahasiswa, maka perlu dikembangkan suatu video yang dapat memvisualisasikan teknik jahit busana. Metoda Research and Development (R&D) dengan model 4D (four-D) yang dikembangkan oleh Thiagarajan 1974 digunakan pada penelitian ini. Penelitian ini terdiri dari empat tahapan, yaitu define (tahap pendefinisian), design (tahap perancangan), develop (tahap pengembangan), disseminate (penyebaran). Video pembelajaran teknik menjahit busana didesain menggunakan Macromedia Flash 8. Hasil yang diperoleh dari penelitian ini adalah video pembelajaran yang valid dan praktis. Berdasarkan temuan itu diharapkan bisa menjadi desain pembelajaran yang dapat meningkatkan proses pembelajaran pada mata kuliah Busana Dasar secara signifikan di IKK FPP UNP. Kata Kunci: video, teknik menjahit, busana dasar.AbstractThis article discusses about Development of Instructional Videos for Clothing Sewing Techniques in Basic Fashion Courses that are valid and practical. The implementation of this lecture really requires quite high reasoning in understanding each step in the process of sewing clothes, so that a special method is needed to be able to describe sewing processes in real terms to students, so a video that can visualize fashion sewing techniques is needed. The Research and Development (R & D) method with a 4D model (four-D) developed by Thiagarajan 1974 was used in this study. This research consists of four stages, namely define, design, develop and disseminate. Learning videos of fashion sewing techniques are designed using Macromedia Flash 8. The results obtained from this study are valid and practical learning videos. Based on the findings, it is expected to be able to be a learning design that can improve the learning process in Basic Clothing courses significantly in IKK FPP UNP. Keywords: video, sewing techniques, basic fashion.
PENGEMBANGAN BAHAN AJAR PEMBUATAN SULAMAN TIMBUL PADA MATA KULIAH SULAMAN UNIVERSITAS NEGERI PADANG
Authors: Syafrina Ira , Nelmira Weni 
Published: July 2019

AbstrakPenelitian ini dilatar belakangi untuk mengatasi permasalahan mahasiswa dalam perkuliahan Sulaman pada materi membuat sulaman timbul, dimana masih terbatasnya referensi mengenai materi Membuat Sulaman Timbul. Tujuan dari penelitian ini untuk menghasilkan media pembelajaran berupa bahan ajar yang valid dan praktis. Penelitian ini merupakan penelitian Research and Development (R&D). Prosedur penelitian menggunakan model 4-D yang terdiri dari tahap pendefenisian (Define), tahap perancangan (Design), tahap pengembangan (Develop) dan tahap (Disseminate). Namun dalam penelitian ini desseminate tidak digunakan karena mengingat keterbatasan peneliti. Data diperoleh dari uji validitas, uji praktikalitas dosen pembina mata kuliah, uji praktikalitas kelompok kecil dan uji praktikalitas kelompok besar. Validator terdiri atas validasi media dan validasi materi yang berjumlah 4 orang. Berdasarkan hasil uji validitas bahan ajar Sulaman diperoleh skor rata-rata 4,35 dengan kategori sangat valid. Selanjutnya dari hasil uji praktikalitas diperoleh skor 85% dengan kategori sangat praktis. Maka dapat disimpulkan bahwa bahan ajar ini layak digunakan sebagai media pembelajaran sulaman timbul. Kata Kunci: bahan, ajar, sulaman, timbul.AbstractThis research aims to solve the problems of students lectures of embroidery on embroidered embroidery material. There are still limited references to the material of Making Embossed Embroideries. The purpose of this study is to produce learning media that contain valid and practical teaching materials. This research is a Research and Development (R & D) research. The research procedure uses a 4-D model consisting of defining (definition), per-design, development design, and development (dissemination). But in this study, it was not used as a consideration for research. Data were obtained from validity tests, practicality tests of lecturer advisors, small group practicality tests and large group practicality tests. The validator consists of media validation and material validation collected by 4 people. Based on the results of the validity test of Sulaman teaching materials obtained an average score of 4.35 with a very valid category. Furthermore, from the practicality test results obtained a score of 85% with a very practical category. It can be concluded that teaching materials are suitable to be used as embroidery learning media arise.Keywords: teaching, materials, embossed, embroideries.
PERBEDAAN HASIL PENCELUPAN BAHAN LINEN DAN KATUN PADA ZAT WARNA ALAM EKSTRAK KULIT BUAH KAKAO (Theobroma Cacao L.) DENGAN MORDAN AIR KELAPA
Authors: Fitriana Lusi , Adriani Adriani 
Published: July 2019

AbstrakPenelitian ini bertujuan untuk mengungkapkan nama warna, gelap terang warna dan kerataan warna pada bahan linen dan katun menggunakan ekstrak kulit buah kakao dengan mordan air kelapa. Penelitian ini penelitian eksperimen. Hasil nama warna pada pencelupan bahan linen tanpa mordan menghasilkan nama warna Amaranth Pink , warna sangat terang dan kerataaan kategori rata, nama warna pada pencelupan bahan katun tanpa mordan menghasilkan nama warna Salmon Pink Darke, warna cukup terang dan kerataaan kategori cukup rata, nama warna pada pencelupan bahan linen menggunakan mordan air kelapa menghasilkan nama Clam Shell Pink, warna kategori terang dan kerataaan kategori rata, nama warna pada pencelupan bahan katun menggunakan mordan air kelapa menghasilkan nama Warm Brown warna kategori cukup terang dan kerataaan warna kategori cukup rata. Kata Kunci: kulit buah kakao, air kelapa.AbstractThis study aim of this research is to reveal the color, dark color of the color and color of the linen and cotton materials using cocoa fruit extract with coconut water mordan. This research is experimental research. The name of the color name on dyeing of mordant linen makes the color name of Amaranth Pink , a very bright color and a flat category, the color name of dyeing cotton without mordant yields the color name of Salmon Pink Darke, fairly bright colors and fairly flat category, the color name of the dyeing of linen material using mordan coconut water produces the name Clam Shell Pink, the category of bright category and flat category, the name of the color on the dyeing of cotton using mordan coconut water categories are quite bright and the color category is fairly flat. Keywords: cocoa fruit skin, coconut water.
PERANCANGAN ILUSTRASI CERITA RAKYAT ANGGUN NAN TONGGA MELALUI MEDIA E-BOOK
Authors: Husna Assaidatul , Sudiani Yoni , Ariesta Olvyanda 
Published: July 2019

AbstrakPerancangan ini bertujuan untuk menyajikan kembali cerita rakyat Anggun Nan Tongga sehingga dapat memperkenalkan dan meningkatkan daya tarik remaja terhadap cerita rakyat Indonesia tersebut. Anggun Nan Tongga merupakan seorang pemuda yang berupaya menjaga harga diri keluarganya, namun dalam upayanya tersebut Anggun Nan Tongga hehilangan kepercayaan dari kekasihnya Putri Gondan Gandoriah. Proses perancangan diawali dengan pengumpulan data melalui observasi, studi pustaka, wawancara, dan kuesioner selanjutnya menentukan konsep visual, perancangan karakter, sinopsis, premis, plot, storyline, storyboard, pewarnaan digital, me-layout dan pengaplikasian. Hasil yang dicapai adalah menghadirkan ilustrasi dalam bentuk karya visual ilustrasi dengan target audiens remaja berusia 13-18 tahun. Dengan adanya e-book ilustrasi Anggun Nan Tongga diharapkan cerita rakyat ini mudah dijangkau oleh remaja yang saat ini dekat dengan penggunaan internet. Serta elemen-elemen grafis seperti ilustrasi, layout, warna, tipografi/teks menjadi unsur penting dalam merancang ilustrasi cerita rakyat ini sehingga dapat menarik perhatian remaja.Kata Kunci: anggun dan tongga, e-book, ilustrasi.AbstractThis design aims to present back Anggun Nan Tongga folklore so that it can introduce and enhance the appeal of adolescent to the story of the people of Indonesia. Anggun Nan Tongga is a young man who seeks to maintain the dignity of his family, but in the effort Anggun Nan Tongga losing the trust of Princess Gondan Gandoriah lover. The design process begins with data collection through observation, interview, literature study, and further questionnaire determines visual concepts, character design, synopsis, premise, plot, storyline, storyboard, digital coloring, layout and application. The result is illustration in visual illustration with target audience of 13-18 year old teenager. With the e-book illustration Anggun Nan Tongga expected this folklore easy to reach by adolescents who are currently close to the use of the internet. As well as graphic elements such like illustrations, layouts, colors, typography / text become an important element in designing this folklore illustration so as to attract the attention of adolescents. Keywords: anggun dan tongga, e-book, ilustrasi.
KERAJINAN SULAMAN KRUISTIK DI NAGARI EMBUNPAGI KECAMATAN MATUR KABUPATEN AGAM SUMATERA BARAT
Authors: Cahyani Diah , Nelmira Weni 
Published: July 2019

AbstrakPermasalahan dalam penelitian ini adalah untuk mengetahui kerajinan sulaman kruistik di nagari Embunpagi Kabupaten Agam. Kerajinan sulaman kruistik merupakan salah satu kerajinan di Nagari Embunpagi yang mempunyai nilai keindahan tersendiri yang banyak diminati. Sulaman kruistik adalah sulaman yang memakai jahitan benang yang bersilangan membentuk huruf x diatas kain tenunan sejajar.Penelitian ini bertujuan untuk mendeskripsikan bentuk kerajinan sulaman kruistik dilihat dari segi desain dan motif di Nagari Embunpagi. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Jenis data yaitu berupa data primer yaitu data yang diperoleh dari pimpinan dan karyawan usaha dan data sekunder yang diperoleh dari dokumentasi. Teknik pengumpulan data dengan cara melalui wawancara, observasi dan dokumentasi. Teknik analisa data yang dilakukan bersifat induktif berdasarkan fakta- fakta yang ditemukan dan penarikan kesimpulan. Hasil penelitian yang diperoleh adalah bentuk desain motif berupa naturalis dengan bentuk bunga dan daun, dan bentuk geometris berupa garis- garis yang disusun.. Kata Kunci: sulaman, kruistik embunpagi.AbstractThe problem in this study was to find out about the crusical embroidery craft in the Embunpagi village of Agam Regency. Crystalline embroidery is one of the handicrafts in Nagari Embunpagi that has its own beauty value that is in great demand. Crewistic embroidery is embroidery that uses cross stitches forming letters x on parallel woven fabrics. The aim of this study is to describe the shape of the crew embroidery craft in terms of design and motif in Nagari Embunagi. The method used in this research is qualitative method. The type of data is in the form of primary data, namely data obtained from business leaders and employees and secondary data obtained from documentation. Data collection techniques by means of interviews, observation and documentation. Data analysis techniques performed are inductive based on facts found and conclusions drawn. The results of the research obtained are the form of motif design in the form of naturalists with flower and leaf shapes, and geometric shapes in the form of lines arranged. Keywords: needlepoint, embunpagi.
Primary amebic meningoencephalomyelitis caused by Naegleria fowleri in a south-central black rhinoceros (Diceros bicornis minor)
Authors: Yaw Taylor J. , O'Neil Pat , Gary Joy M. , Ali Ibne K. , Cowart Jerry R. , Wallace Roberta S. , Estep J. Scot 
Published: July 2019

Abstract
CASE DESCRIPTION A 20-year-old female south-central black rhinoceros (Diceros bicornis minor) was evaluated because of an acute onset of CNS deficits.
CLINICAL FINDINGS The rhinoceros had no history of illness. Clinical signs included acute lethargy, ataxia, and decreased appetite. Hematologic abnormalities included leukocytosis with neutrophilia and a profound left shift. Results of serum biochemical analysis revealed hypophosphatemia but no other abnormalities. Results of a quantitative PCR assay for West Nile virus and an assay for anti–Neosporum caninum antibodies in serum were negative; the patient was seropositive for multiple Leptospira serovars.
TREATMENT AND OUTCOME Antimicrobials and anti-inflammatory agents were administered, but the condition of the rhinoceros worsened overnight; despite treatment with additional anti-inflammatory and antimicrobial agents, IV fluids, and thiamine, it became obtunded and died of respiratory arrest ≤ 24 hours later. Necropsy revealed severe, diffuse, suppurative, and histiocytic meningo-encephalomyelitis involving the cerebrum, cerebellum, and spinal cord. Amebic trophozoites were observed on histologic examination of affected tissue. Infection with Naegleria fowleri was confirmed by results of immuno-histochemical analysis and a multiplex real-time PCR assay.
CLINICAL RELEVANCE Findings suggested that south-central black rhinoceros are susceptible to the free-living ameba N fowleri. Ameba-induced meningoencephalomyelitis should be considered as a differential diagnosis for rhinoceros that have an acute onset of neurologic signs. Diagnosis of N fowleri infection in an animal has a profound public health impact because of potential human exposure from the environment and the high fatality rate in people with N fowleri infection.