bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of a highly fluorescent N,N‐dimethyl benzylamine–palladium(II) curcuminate complex and its application for determination of trace amounts of water in organic solvents
Authors: Zargoosh Kiomars , Reisi Oshtorjani Reihane , Karami Kazem , Hashemi Sara 
Published: August 2019

AbstractIn this work a new highly fluorescent N,N‐dimethyl benzylamine–palladium(II) yu complex was synthesized by the reaction of [Pd2{(C,N–C6H4CH2N(CH3)2}2(μ‐OAc)]2] with curcumin. The structure of the synthesized complex was characterized using Fourier transform infra‐red (FT‐IR) spectroscopy, 1H nuclear magnetic resonance spectroscopy, and elemental analysis. Fluorescence quantum yield (ΦF) values of the synthesized complex in dimethyl sulfoxide (DMSO), acetonitrile, ethanol, and methanol were 0.160, 0.104, 0.068, and 0.061, respectively. The fluorescence signal of the complex in the organic solvents was very sensitive to the water content of the organic solvent. The quenching effect of water was used to determine trace amounts of water in the heteroatom‐containing organic solvents (ethanol, methanol, acetonitrile) and redox‐active solvents (DMSO). The linear ranges for determination of water (v/v %) in ethanol, DMSO and acetonitrile were found to be 0.03–14.5, 0.08–13.8, and 0.07–18.8, respectively. Two linear ranges were found for determination of water (v/v %) in methanol (0.1–1.2 and 4.7–25.0). Detection limit (DL) values were calculated to be 0.001, 0.05, 0.004, and 0.01 (v/v %) in ethanol, methanol, acetonitrile, and DMSO, respectively. The proposed method overcomes the problems of the standard Karl Fischer method for determination of water in DMSO. In addition, it gave the best DL value for determination of water in ethanol compared with all published papers to date.
Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells
Authors: Ietta Francesca , Valacchi Giuseppe , Benincasa Linda , Pecorelli Alessandra , Cresti Laura , Maioli Emanuela 
Published: August 2019

AbstractRottlerin is a cytostatic and cytotoxic drug in a variety of cancer cells. Our previous experience demonstrated that depending upon the genetic/biochemical background of cancer cells, rottlerin is able to induce both apoptotic and autophagic cell death, or dramatically disturb protein homeostasis leading to lethal cellular atrophy. In the current study, we investigated the cytotoxic effects and mechanisms of rottlerin against human amelanotic A375 melanoma cells. In this cell line, rottlerin exhibits its main and newest cytotoxic properties, that is, growth arrest, apoptosis induction, and translation shutoff. In fact, the drug, time‐, and dose‐dependently, markedly inhibited cell proliferation through cyclin D1 downregulation and induced apoptotic cell death as early as after 18 h treatment. Mechanistically, rottlerin triggered apoptosis by both intrinsic and extrinsic pathways. Both pathways are likely activated by the downregulation of the antiapoptotic B‐cell lymphoma 2 (Bcl‐2) protein, which simultaneously affects mitochondrial and endoplasmic reticulum (ER) membranes stability. Concomitantly to extrinsic apoptosis induction, the rottlerin‐activated ER stress/eukaryotic initiation factor 2 (eIF2) α axis blocked the translational apparatus. The altered proteostasis precluded the complete cells' rescue from death in the presence of apoptosis inhibitors.
Risk stratification for lung adenocarcinoma on EGFR and TP53 mutation status, chemotherapy, and PD‐L1 immunotherapy
Authors: Wu Chih‐Hsun , Hwang Ming‐Jing 
Published: August 2019

AbstractThe overall survival rates for lung cancer remain unsatisfactorily low, even for patients with biomarkers for which target therapies or immunotherapies are recommended. Better identification of at‐risk patients is needed to achieve more effective personalized treatment. Here, we derived a risk‐stratifying gene signature consisting of five genes that had the greatest differential expression by stage from lung adenocarcinoma (LUAD) transcriptomes. The new gene signature enabled survival prognosis for multiple LUAD datasets from different platforms of transcriptomics and risk stratification for patients with and without a mutation in TP53 or EGFR, with high and low levels of PD‐L1, and with and without adjuvant chemotherapy treatment. Using these evaluations, it was also shown to be more robust compared to several other gene signatures. Functional analysis of the five genes and their protein‐protein interaction partners indicated that they are functionally enriched in cell cycle, endocytosis, and EGFR regulation, which are biological processes associated with lung cancer and drug resistance. Extensive discussions on related experimental studies suggest that the five genes are novel and sensible targets for developing new drugs and/or tackling drug resistance problems for LUAD.
Lithium–Bromide Exchange versus Nucleophilic Addition of Schiff's Base: Unprecedented Tandem Cyclisation Pathways
Authors: Orr Samantha A. , Border Emily C. , Andrews Philip C. , Blair Victoria L. 
Published: August 2019

AbstractInvited for the cover of this issue is the group of Philip C. Andrews and Victoria L. Blair at Monash University, Melbourne. The image depicts the La Trobe reading room in Melbourne's State Library as a way of illustrating the manuscript′s discussion of textbook techniques. Read the full text of the article at 10.1002/chem.201902140.
Enantioseparation of chiral perfluorooctane sulfonate (PFOS) by supercritical fluid chromatography (SFC): Effects of the chromatographic conditions and separation mechanism
Authors: Zhao Lu , Chen Fangfang , Guo Fangjie , Liu Weiping , Liu Kai 
Published: August 2019

AbstractPerfluorooctane sulfonate (PFOS) is one of the most frequently detected perfluoroalkyl substances in environmental and human samples. Previous studies have shown that nonracemic PFOS in biological samples can be used as a marker of PFOS exposure sources. In recent years, supercritical fluid chromatography (SFC) has emerged as a powerful method to separate chiral compounds. In this study, a method of perfluoro‐1‐methylheptane sulfonate (1 m‐PFOS) enantioseparation by SFC was established. The optimal separation was obtained using a Chiralpak QN‐AX column with CO2/2‐propanol (70/30, v/v) as the mobile phase with a flow rate of 1 mL/min, column temperature was 32°C, and BPR pressure was 1800 psi. The resolution (Rs) and retention time were 0.88 and 130 minutes, respectively. This method is more economic and greener than HPLC. Modifier pH and column temperature were determined to be significant factors of SFC chiral separation. Modifier pH is negatively correlated with the retention factors and Rs. Adsorption thermodynamics were used to explain the influence of temperature change, and it was concluded that the transfer of two enantiomers from the mobile phase to the stationary phase is enthalpy‐driven. Enantioseparation of 1 m‐PFOS by SFC follows the same rules of ion exchange as those for the chiral separation by HPLC.
Indication‐specific event rates among hospitalized patients undergoing continuous cardiac monitoring
Authors: Cantillon Daniel J. , Burkle Alicia , Kirkwood Desiree , Loy Molly , Amuthan Ram , Pengel Shannon , Tote John , Morris William , Houghtaling Penny L. , Hamilton Aaron C. , Petre Marc , Khot Umesh N. , Lindsay Bruce D. 
Published: August 2019

AbstractBackgroundCardiac telemetry monitoring is widely utilized for a variety of clinical indications, yet indication‐specific event rates for monitored patients are seldomly reported.HypothesisHigh‐risk hospitalized patients for clinical deterioration can be identified using standardized telemetry monitoring indications.MethodsAdjudicated data from events triggering emergency response team (ERT) activation were systematically characterized at the Cleveland Clinic from among standardized telemetry indications ordered over a 13‐month period.ResultsAmong 72 199 orders created for telemetry monitored patients, ERT activation occurred in 2677 patients (3.7%), of which 1326 (49.5%) were cardiac‐related. Patients with deep venous thrombosis or pulmonary embolism (DVT/PE) demonstrated the highest overall event rate (ERT: n = 41 of 593 pts [6.9%]; 25/41 cardiac related [61%]). Cardiac‐related events were proportionally highest among patients with coronary disease awaiting revascularization (ERT: n = 19 of 847 patients [2.2%]; 13/19 cardiac‐related [68.4%]). Arrhythmia‐specific events were highest among patients who underwent cardiac surgery (n = 78 of 193 cardiac‐related ERT [40.4%]), and patients with known or suspected tachyarrhythmias (n = 318 of 788 cardiac‐related ERT [40.4%]). Bubble plot analysis identified patients hospitalized with DVT/PE, drug or alcohol exposures, and acute coronary syndrome as among the highest overall and cardiac‐related events while identifying patients with respiratory disorder monitoring indications as carrying the highest noncardiac event rate.ConclusionHigh‐risk hospitalized patients can be identified by telemetry indication and prioritized according to concerns for cardiac, arrhythmia‐specific and noncardiac clinical deterioration. This is particularly useful when monitored bed resources are constrained.
Intratelencephalic projections of the avian visual dorsal ventricular ridge: Laminarly segregated, reciprocally and topographically organized
Authors: Fernández Máximo , Ahumada‐Galleguillos Patricio , Sentis Elisa , Marín Gonzalo , Mpodozis Jorge 
Published: August 2019

AbstractRecent reports have shown that the avian visual dorsal ventricular ridge (DVR) is organized as a trilayered complex, in which the forming layers—the thalamo‐recipient entopallium (E), an overlaying nidopallial stripe called intermediate nidopallium (NI), and the dorsally adjacent mesopallium ventrale—appear to be extensively interconnected by topographically organized columns of reciprocal axonal processes running perpendicular to the layers, an arrangement highly reminiscent to that of the sensory cortices of mammals. In the present report, we implemented in vivo anterograde and retrograde tracing techniques aiming to elucidate the organization of the connections of this complex with other pallial areas. Previous studies have shown that the efferent projections of the visual DVR originate mainly from the NI and E, reaching several distinct associative and premotor nidopallial areas. We found that the efferents from the visual DVR originated solely from the NI, and confirmed that the targets of these projections were the pallial areas described by previous studies. We also found novel projections from the NI to the visual hyperpallium, and to the lateral striatum. Moreover, we found that these projections were reciprocal, topographically organized, and originated from different cell populations within the NI. We conclude that the NI constitutes a specialized layer of the visual DVR that form the core of a dense network of highly specific connections between this region and other higher order areas of the avian pallium. Finally, we discuss to what extent these hodological properties resemble those of the mammalian cortical layers II/III.
trans‐Platinum(II) Thionate Complexes: Synthesis, Structural Characterization, and in vitro Biological Assessment as Potent Anticancer Agents
Authors: Sakamaki Yoshie , Ahmadi Mirsadeghi Hasti , Fereidoonnezhad Masood , Mirzaei Faezeh , Moghimi Dehkordi Zahra , Chamyani Samira , Alshami Mia , Abedanzadeh Sedigheh , Shahsavari Hamid R. , Beyzavi M. Hassan 
Published: August 2019

AbstractA series of Pt(II) complexes trans‐[Pt(PPh2allyl)2(κ1‐S‐SR)2], 1, PPh2allyl=allyldiphenylphosphine, SR=pyridine‐2‐thiol (Spy, 1 a), 5‐(trifluoromethyl)‐pyridine‐2‐thiol (SpyCF3‐5, 1 b), pyrimidine‐2‐thiol (SpyN, 1 c), benzothiazole‐2‐thiol (Sbt, 1 d), benzimidazole‐2‐thiol (Sbi, 1 e), were synthesized. They were characterized by NMR, HR ESI‐MS, and X‐ray crystallography. Treatment of human cancer cell lines (A549, SKOV3, MCF‐7) with these complexes resulted in promising antitumor effects in comparison with cisplatin. These compounds showed suitable selectivity between tumorigenic and non‐tumorigenic (MCF‐10 A) cell lines. Analyses of cell cycle progression and apoptosis were conducted for 1 a, the most cytotoxic compound, to screen dose/time response and to study the antiproliferative mechanism. An electrophoresis mobility shift assay was performed to assess the direct interaction of 1 a with DNA and the strong genotoxic ability was indicated through the comet assay method.
Design and analysis of 0.9 and 2.3‐GHz concurrent dual‐band CMOS LNA for mobile communication
Authors: Roobert A. Andrew , Rani D. Gracia Nirmala 
Published: August 2019

SummaryA complementary metal‐oxide‐semiconductor (CMOS) dual‐band low‐noise amplifier (LNA) for 2G/3G/4G mobile communications is presented. It operates at 0.9 and 2.3 GHz of frequencies. The dual‐band operation is achieved by adding a modified notch‐filtering path in the wideband LNA. The modified notch‐filtering path does not require additional power to cancel the signals of the stop band frequency. The impact of the filtering path in the proposed LNA is analyzed. Improved results are observed in dual bands of frequency. Sustainability of the LNA under process corner variation and temperature variation are examined, and it is found to be suitable for the application. The proposed LNA is designed at 90‐nm technology in Cadence Virtuoso with 0.5 and 0.6‐V supply. The post‐layout simulation shows 22 dB of gain (S21), 2 dB of Noise Figure (NF), and −5.5 dBm of IIP3 at the high band. In the low band, 24 dB of S21, 2.7 dB of NF, and −6.65 dBm of IIP3 are reached. The circuit consumes 5.2 mW of power and 0.0918 mm2 of area. The efficiency of the LNA is estimated by the figure of merit, and comparable results are secured in the proposed work.
Expression of IL‐34 correlates with macrophage infiltration and prognosis of diffuse large B‐cell lymphoma
Authors: Noyori Osamu , Komohara Yoshihiro , Nasser Hesham , Hiyoshi Masateru , Ma Chaoya , Pan Cheng , Carreras Joaquim , Nakamura Naoya , Sato Ai , Ando Kiyoshi , Okuno Yutaka , Nosaka Kisato , Matsuoka Masao , Suzu Shinya 
Published: August 2019

AbstractObjectivesInfiltration of macrophages through the tyrosine kinase receptor CSF1R is a poor prognosis factor in various solid tumors. Indeed, these tumors produce CSF1R ligand, macrophage colony‐stimulating factor (M‐CSF) or interleukin‐34 (IL‐34). However, the significance of these cytokines, particularly, the newly discovered IL‐34 in haematological malignancies, is not fully understood. We therefore analysed the role of IL‐34 in diffuse large B‐cell lymphoma (DLBCL), the most common subtype of malignant lymphoma.MethodsWe analysed formalin‐fixed paraffin‐embedded lymphoma tissues of 135 DLBCL patients for the expression of IL‐34 and the number of macrophages, and the survival of these patients. The expression of IL‐34 in DLBCL cell lines and the activity of IL‐34 to induce the migration of monocytic cells were also characterised.ResultsSeveral lymphoma tissues showed a clear IL‐34 signal, and such signal was detectable in 36% of patients. DLBCL cell lines also expressed IL‐34. Interestingly, the percentage of IL‐34+ patients in the activated B‐cell subtype was significantly higher than that in the germinal centre B‐cell subtype. More interestingly, IL‐34+ patients showed shorter survival periods and higher number of macrophages in lymphoma tissues. The recruitment of monocytes is likely the first step for the higher macrophage density in the IL‐34+ lymphoma tissues. Indeed, IL‐34 induced the migration of monocytic cells.ConclusionOur results raise the possibility that IL‐34 in lymphoma tissues of DLBCL patients recruits monocytes, leading to the higher number of macrophages in the tissues and poor prognosis of patients. IL‐34 may be an additional therapeutic target of DLBCL.
Obliquely propagating quantum solitary waves in quantum‐magnetized plasma with ultra‐relativistic degenerate electrons and positrons
Authors: Soltani H. , Mohsenpour T. , Sohbatzadeh F. 
Published: August 2019

AbstractThe oblique propagation of the quantum electrostatic solitary waves in magnetized relativistic quantum plasma is investigated using the quantum hydrodynamic equations. The plasma consists of dynamic relativistic degenerate electrons and positrons and a weakly relativistic ion beam. The Zakharov‐Kuznetsov equation is derived using the standard reductive perturbation technique that admits an obliquely propagating soliton solution. It is found that two types of quantum acoustic modes, that is, a slow acoustic mode and fast acoustic mode, could be propagated in our plasma model. The parameter that determines the nature of soliton, that is, compressive or rarefactive soliton, for slow mode is investigated. Our numerical results show that for the slow mode, the determining parameter is ion beam velocity in the case of relativistic degenerate electrons. We also have examined the effects of plasma parameters (like the beam velocity, the density ratio of positron to electron, the relativistic factor, and the propagation angle) on the characteristics of solitary waves.
Energy‐delay‐aware caching strategy in green CCN using markov approximation
Authors: Dehghani Fereshte , Movahhedinia Naser 
Published: August 2019

SummaryOne of the basic challenges in content‐centric networking (CCN) is how to optimize the overall energy consumption of content transmission and caching. Furthermore, designing an appropriate caching policy that considers both energy consumption and quality of service (QoS) is a major goal in green CCN. In this paper, the problem of minimizing the total CCN energy consumption while being aware of the end‐to‐end delay is formulated as an integer linear programming model. Since it is an Non‐deterministic Polynomial‐time (NP)‐hard problem, the Markov approximation method for an energy‐delay aware caching strategy (MAEDC) is proposed through a log‐sum‐exp function to find a near‐optimal solution in a distributed manner. The numerical results show that the MAEDC achieves near‐optimal energy consumption with better delay profile compared with the optimal solution. Moreover, due to the possibility of distributed and parallel processing, the proposed method is proper for the online situation where the delay is a crucial issue.
Dissecting the presence of malignant squamous cells in pancreatic cytopathology: A case series
Authors: Sydney Guy I. , Ioakim Kalliopi J. , Sergentanis Theodoros N. , Tsiotos Gregory G. , Kyriakidou Vasiliki , Sepsa Athanasia , Theocharis Stamatios , Salla Charitini , Nikas Ilias 
Published: August 2019

AbstractThe presence of malignant squamous cells in pancreatic cytopathology is a rare phenomenon that results either from a primary or a metastatic process. Pancreatic adenosquamous carcinoma (PASC) represents the most common variant of pancreatic ductal adenocarcinoma and is associated with a dismal prognosis. Within the period of 2013‐2018, the archives of “Hygeia and Mitera Hospital” were searched for pancreatic cytopathology‐related diagnoses that included the interpretation of “malignant squamous cells present.” All fine needle aspirations (FNAs) of pancreatic lesions, including liver metastases in patients with known pancreatic primaries, were retrieved along with their relevant clinical information. Five pancreatic and two liver FNAs acquired from a total of six patients were reexamined. None of these patients had any documented history of primary squamous malignancy elsewhere. All pancreatic and one of the two liver FNAs showed malignant squamous cells, identified based on either morphology or immunochemistry. The other liver FNA represented a metastatic deposit which comprised of only a glandular component, whereas the associated pancreatic FNA exhibited both squamous and glandular counterparts. Most cases characteristically showed necrosis and keratinization. Of interest, two cases revealed the presence of tumor‐associated giant cells. In conclusion, the presence of malignant squamous cells in pancreatic FNAs could mean the presence of PASC, especially when there is no documented history of a primary malignancy and a complete clinical and imaging workup has been performed. Immunochemistry on cell block material could help to confirm squamous differentiation in the absence of overt keratinization.
A naturalistic comparison of two inpatient treatment protocols for adults with anorexia nervosa: Does reducing duration of treatment and external controls compromise outcome?
Authors: Paquin Hodge Chloé , Gauvin Lise , St‐Hilaire Annie , Israel Mimi , Azzi Michelle , Kahan Esther , Thaler Lea , Dansereau Eve , Steiger Howard 
Published: August 2019

AbstractObjectiveAlthough hospitalization is sometimes necessary when treating individuals with anorexia nervosa, the available literature provides limited guidance to inform decisions surrounding optimal components or duration of inpatient treatments. We report observational data comparing outcomes of two inpatient treatments. The first was longer and more strictly structured around a Contingency Management Protocol (CMP) emphasizing external incentives for achieving weight‐restoration goals; the second was a shorter Autonomy Support Protocol (ASP) that progressively increased patient autonomy around meal management without external incentives.MethodWe compared data from 41 patients who participated in the ASP to a historical sample of 41 patients treated using the CMP. At admission, discharge, and post‐treatment follow‐up, participants completed the Eating Disorder Examination Questionnaire and the Behavior and Symptom Identification Scale‐32, and we measured height and weight to compute body mass index.ResultsMultilevel modeling analyses that controlled for time in treatment and time in follow‐up indicated the two protocols yielded equivalent in‐treatment gains and post‐treatment loss of gains.DiscussionOur results indicate that shorter inpatient stays emphasizing autonomous control over eating behavior may yield outcomes that are equivalent to those of lengthier, more stringent, and more costly approaches implicating external incentives and controls.