bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic removal of rare variant of leiomyoma in the female inguinal canal: a report of two cases
Authors: Byun Geon Young , Koo Bum Hwan , Lee Seung Geun , Kim Myoung Jin , Lee Sung Ryul 
Published: July 2019

Abstract
Angioleiomyoma and lipoleiomyoma are rarely found tumors in the inguinal canal. We present two cases of laparoscopic removal of angioleiomyoma and lipoleiomyoma in the female inguinal canal. In Case 1, a 35-year-old woman was admitted to our hospital with left inguinal swelling and intermittent pain. A hypoechoic well-marginated mass was observed on ultrasonography. Laparoscopic complete tumor excision and posterior wall repair were performed, and a diagnosis of angioleiomyoma was confirmed on histopathological evaluation. In Case 2, a 55-year-old woman was admitted with a painful right inguinal swelling. A hypoechoic well-marginated ovoid mass was observed on ultrasonography. Laparoscopic complete tumor excision and posterior wall repair were performed, and a diagnosis of lipoleiomyoma was confirmed on histopathological evaluation. Laparoscopic tumor excision and posterior wall repair are effective treatments of leiomyomas in the inguinal canal.
Chalutzim—Zionist Photography in Germany and Palestine in the 1930s: A Comparative Analysis of Images
Authors: Pilarczyk Ulrike 
Published: July 2019

Abstract
This article reconstructs and compares photographic perspectives on the historical phenomenon of preparing German-Jewish youth for emigration from Germany, and their subsequent training in Palestinian kibbutzim in the framework of the hachshara and the youth aliyah. It considers the photographers’ status, differentiating between professional photography and the work of amateurs, and investigates the use and addressees of these images. The image analysis that underlies this study examines facets of the photographic and pictorial conception of chalutzian youth, including motifs, style, and atmospheres. In the process, photography is classified as a unique historical image source, in which the conditions of the time inscribe themselves even beyond personal and political intentions, interests, and contexts of usage. The image analysis also aims to reconstruct the specific, visually represented individual and collective experiences of the producers and addressees of photographic images in Germany and Mandatory Palestine.
The elephant in the room: the importance of the details of massive star formation in molecular clouds
Authors: Grudić Michael Y , Hopkins Philip F 
Published: July 2019

Abstract
Most simulations of galaxies and massive giant molecular clouds (GMCs) cannot explicitly resolve the formation (or predict the main-sequence masses) of individual stars. So they must use some prescription for the amount of feedback from an assumed population of massive stars (e.g. sampling the initial mass function, IMF). We perform a methods study of simulations of a star-forming GMC with stellar feedback from UV radiation, varying only the prescription for determining the luminosity of each stellar mass element formed (according to different IMF sampling schemes). We show that different prescriptions can lead to widely varying (factor of ∼3) star formation efficiencies (on GMC scales) even though the average mass-to-light ratios agree. Discreteness of sources is important: radiative feedback from fewer, more-luminous sources has a greater effect for a given total luminosity. These differences can dominate over other, more widely recognized differences between similar literature GMC-scale studies (e.g. numerical methods, cloud initial conditions, presence of magnetic fields). Moreover the differences in these methods are not purely numerical: some make different implicit assumptions about the nature of massive star formation, and this remains deeply uncertain in star formation theory.
Joint estimation of the Epoch of Reionization power spectrum and foregrounds
Authors: Sims Peter H , Pober Jonathan C 
Published: July 2019

ABSTRACTThe power spectrum of redshifted 21 cm emission brightness temperature fluctuations is a powerful probe of the Epoch of Reionization (EoR). However, bright foreground emission presents a significant impediment to its unbiased recovery from interferometric data. We estimate the power spectrum within a Bayesian framework and demonstrate that incorporating a priori knowledge of the spectral structure of foregrounds in the large spectral scale component of the data model enables significantly improved modelling of the foregrounds without increasing the model complexity. We explore two astrophysically motivated parametrizations of the large spectral scale model: (i) a constant plus power-law model of the form $q_{0}+q_{1}(\nu /\nu _{0})^{b_{1}}$ for two values of b1: b1 = 〈β〉GDSE and b1 = 〈β〉EGS, the mean spectral indices of the Galactic diffuse synchrotron emission and extragalactic source foreground emission, respectively; and (ii) a constant plus double power-law model of the form $q_{0}+q_{1}(\nu /\nu _{0})^{b_{1}}+q_{2}(\nu /\nu _{0})^{b_{2}}$ with b1 = 〈β〉GDSE and b2 = 〈β〉EGS. We estimate the EoR power spectrum from simulated interferometric data consisting of an EoR signal, Galactic diffuse synchrotron emission, extragalactic sources, and diffuse free–free emission from the Galaxy. We show that, by jointly estimating a model of the EoR signal with the constant plus double power-law parametrization of the large spectral scale model, unbiased estimates of the EoR power spectrum are recoverable on all spatial scales accessible in the data set, including on the large spatial scales that were found to be contaminated in earlier work.
A stable finite-volume method for scalar field dark matter
Authors: Hopkins Philip F 
Published: July 2019

ABSTRACT
We describe and test a family of new numerical methods to solve the Schrödinger equation in self-gravitating systems, e.g. Bose–Einstein condensates or ‘fuzzy’/ultra-light scalar field dark matter. The methods are finite-volume Godunov schemes with stable, higher order accurate gradient estimation, based on a generalization of recent mesh-free finite-mass Godunov methods. They couple easily to particle-based N-body gravity solvers (with or without other fluids, e.g. baryons), are numerically stable, and computationally efficient. Different sub-methods allow for manifest conservation of mass, momentum, and energy. We consider a variety of test problems and demonstrate that these can accurately recover solutions and remain stable even in noisy, poorly resolved systems, with dramatically reduced noise compared to some other proposed implementations (though certain types of discontinuities remain challenging). This is non-trivial because the ‘quantum pressure’ is neither isotropic nor positive definite and depends on higher order gradients of the density field. We implement and test the method in the code gizmo.
On the ultra-compact nature of the neutron star system 1RXS J170854.4−321857: insights from X-ray spectroscopy
Authors: Armas Padilla M , López-Navas E 
Published: July 2019

ABSTRACT
The relatively small family of ultra-compact X-ray binary systems is of great interest for many areas of astrophysics. We report on a detailed X-ray spectral study of the persistent neutron star low-mass X-ray binary 1RXS J170854.4−321857. We analysed two XMM–Newton observations obtained in late 2004 and early 2005 when, in agreement with previous studies, the system displayed an X-ray luminosity (0.5–10 keV) of ${\sim} 1\times 10^{36}\, \mathrm{erg~s}^{-1}$. The spectrum can be described by a Comptonized emission component with Γ ∼ 1.9 and a distribution of seed photons with a temperature of ∼0.23 keV. A prominent residual feature is present at soft energies, which is reproduced by the absorption model if overabundances of Ne and Fe are allowed. We discuss how similar observables, which might be attributed to the peculiar (non-solar) composition of the plasma donated by the companion star, are a common feature in confirmed and candidate ultra-compact systems. Although this interpretation is still under debate, we conclude that the detection of these features along with the persistent nature of the source at such low luminosity and the intermediate–long burst that it displayed in the past confirms 1RXS J170854.4−321857 as a solid ultra-compact X-ray binary candidate.
Cosmic ray acceleration of cool clouds in the circumgalactic medium
Authors: Wiener Joshua , Zweibel Ellen G , Ruszkowski Mateusz 
Published: July 2019

ABSTRACT
We investigate a mechanism for accelerating cool (104 K) clouds in the circumgalactic medium (CGM) with cosmic rays (CRs), possibly explaining some characteristics of observed high-velocity clouds (HVCs). Enforcing CRs to stream down their pressure gradient into a region of slow streaming speed results in significant build-up of CR pressure which can accelerate the CGM. We present the results of the first two-dimensional magnetohydrodynamic (MHD) simulations of such ‘CR bottlenecks,’ expanding on simpler simulations in 1D. Although much more investigation is required, we find two main results. First, radiative cooling in the interfaces of these clouds is sufficient to keep the cloud intact to CR wave heating. Secondly, cloud acceleration depends almost linearly with the injected CR flux at low values (comparable to that expected from a Milky Way-like star formation rate), but scales sublinearly at higher CR fluxes in 1D simulations. 2D simulations show hints of sublinear dependence at high CR fluxes but are consistent with pure linear dependence up to the CR fluxes tested. It may therefore be plausible to accelerate cool clouds in the CGM to speeds of hundreds of km s−1.
Mean field solar surface dynamo in the presence of partially ionized plasmas and sub-surface shear layer
Authors: Paradkar B S , Chitre S M , Krishan V 
Published: July 2019

AbstractA non-linear α − Ω dynamo in the partially ionized turbulent plasma in the presence of sub-surface velocity shear is studied with mean-field electrodynamics. Such a dynamo is probably operational in the near-surface region of the Sun, where the presence of both neutrals and the velocity shear (due to sub-surface shear layer in the rotation profile) is observationally well established. In particular, we show that the inclusion of ambipolar diffusion leads to a saturation of magnetic field amplitudes in the α − Ω dynamo. We also demonstrate that the temporal evolution of large-scale global magnetic fields follows the well-known pattern similar to the ‘butterfly’ diagram displayed by sunspots. As usual the velocity shear converts part of the poloidal into the toroidal magnetic field which in turn is regenerated largely by the combined kinetic plus Hall helicity, thus closing the dynamo loop. In addition, by allowing temporal variation in the helicity and ambipolar diffusion coefficient we are able to reproduce the grand-minimum type behaviour of the solar dynamo. Details of theoretical model along with numerical computations of dynamo equations in the partially ionized plasma are outlined. The solar surface dynamo model envisaged in this work could operate in conjunction with the global dynamo present in the bulk of the convection zone.
Angular momentum transport in massive stars and natal neutron star rotation rates
Authors: Ma Linhao , Fuller Jim 
Published: July 2019

Abstract
The internal rotational dynamics of massive stars are poorly understood. If angular momentum (AM) transport between the core and the envelope is inefficient, the large core AM upon core-collapse will produce rapidly rotating neutron stars (NSs). However, observations of low-mass stars suggest an efficient AM transport mechanism is at work, which could drastically reduce NS spin rates. Here, we study the effects of the baroclinic instability and the magnetic Tayler instability in differentially rotating radiative zones. Although the baroclinic instability may occur, the Tayler instability is likely to be more effective for AM transport. We implement Tayler torques as prescribed by Fuller, Piro, and Jermyn into models of massive stars, finding they remove the vast majority of the core’s AM as it contracts between the main-sequence and helium-burning phases of evolution. If core AM is conserved during core-collapse, we predict natal NS rotation periods of $P_{\rm NS} \approx 50\!-\!200 \, {\rm ms}$, suggesting these torques help explain the relatively slow rotation rates of most young NSs, and the rarity of rapidly rotating engine-driven supernovae. Stochastic spin-up via waves just before core-collapse, asymmetric explosions, and various binary evolution scenarios may increase the initial rotation rates of many NSs.
Vertical shear-induced resonant triads in Keplerian discs
Authors: Shtemler Yuri , Mond Michael 
Published: July 2019

ABSTRACT
The vertical-shear instability (VSI) is studied through weakly non-linear analysis of unmagnetized vertically isothermal thin Keplerian discs under small radial temperature gradients. Vertically global and radially local axisymmetric compressible perturbations are considered. The VSI excites three classes of quasi-resonant triads of non-linearly interacting modes characterized by distinct temporal evolution. Most of the triads belong to the two-mode regime of non-linear interaction. Such triads are comprised of one unstable non-linear mode that grows quasi-exponentially, and two other modes that practically decoupled from the former. The latter two modes perform non-linear oscillations around their either linear prototypes (class I) or respective initial values (class II). The rest of the resonant triads belong to class III where all three modes exhibit non-linear oscillations. The proposed model describes an intermediate non-linear stage of the VSI prior to its saturation.
Multiple Plasticity Regulators Reveal Targets Specifying an Induced Predatory Form in Nematodes
Authors: Bui Linh T , Ragsdale Erik J 
Published: July 2019

AbstractThe ability to translate a single genome into multiple phenotypes, or developmental plasticity, defines how phenotype derives from more than just genes. However, to study the evolutionary targets of plasticity and their evolutionary fates, we need to understand how genetic regulators of plasticity control downstream gene expression. Here, we have identified a transcriptional response specific to polyphenism (i.e., discrete plasticity) in the nematode Pristionchus pacificus. This species produces alternative resource-use morphs—microbivorous and predatory forms, differing in the form of their teeth, a morphological novelty—as influenced by resource availability. Transcriptional profiles common to multiple polyphenism-controlling genes in P. pacificus reveal a suite of environmentally sensitive loci, or ultimate target genes, that make up an induced developmental response. Additionally, in vitro assays show that one polyphenism regulator, the nuclear receptor NHR-40, physically binds to promoters with putative HNF4α (the nuclear receptor class including NHR-40) binding sites, suggesting this receptor may directly regulate genes that describe alternative morphs. Among differentially expressed genes were morph-limited genes, highlighting factors with putative “on–off” function in plasticity regulation. Further, predatory morph-biased genes included candidates—namely, all four P. pacificus homologs of Hsp70, which have HNF4α motifs—whose natural variation in expression matches phenotypic differences among P. pacificus wild isolates. In summary, our study links polyphenism regulatory loci to the transcription producing alternative forms of a morphological novelty. Consequently, our findings establish a platform for determining how specific regulators of morph-biased genes may influence selection on plastic phenotypes.
From Root to Tips: Sporulation Evolution and Specialization inBacillus subtilisand the Intestinal PathogenClostridioides difficile
Authors: Ramos-Silva Paula , Serrano Mónica , Henriques Adriano O 
Published: July 2019

AbstractBacteria of the Firmicutes phylum are able to enter a developmental pathway that culminates with the formation of highly resistant, dormant endospores. Endospores allow environmental persistence, dissemination and for pathogens, are also infection vehicles. In both the model Bacillus subtilis, an aerobic organism, and in the intestinal pathogen Clostridioides difficile, an obligate anaerobe, sporulation mobilizes hundreds of genes. Their expression is coordinated between the forespore and the mother cell, the two cells that participate in the process, and is kept in close register with the course of morphogenesis. The evolutionary mechanisms by which sporulation emerged and evolved in these two species, and more broadly across Firmicutes, remain largely unknown. Here, we trace the origin and evolution of sporulation using the genes known to be involved in the process in B. subtilis and C. difficile, and estimating their gain-loss dynamics in a comprehensive bacterial macroevolutionary framework. We show that sporulation evolution was driven by two major gene gain events, the first at the base of the Firmicutes and the second at the base of the B. subtilis group and within the Peptostreptococcaceae family, which includes C. difficile. We also show that early and late sporulation regulons have been coevolving and that sporulation genes entail greater innovation in B. subtilis with many Bacilli lineage-restricted genes. In contrast, C. difficile more often recruits new sporulation genes by horizontal gene transfer, which reflects both its highly mobile genome, the complexity of the gut microbiota, and an adjustment of sporulation to the gut ecosystem.
CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5
Authors: Zhang Shuai , Liao Keman , Miao Zengli , Wang Qing , Miao Yifeng , Guo Zhongye , Qiu Yun , Chen Binghong , Ren Li , Wei Zilong , Lin Yingying , Lu Xiaojie , Qiu Yongming 
Published: July 2019

AbstractBackgroundCircular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNA, have been proposed to mediate the progression of diverse types of tumors. Systematic studies of circRNAs have just begun, and the physiological roles of circRNAs remain largely unknown. Here, we focused on elucidating the potential role and molecular mechanism of circular forkhead box O3 (circFOXO3) in glioblastoma (GBM) progression.MethodsFirst, we analyzed circFOXO3 alterations in GBM and noncancerous tissues through real-time quantitative reverse transcription PCR (qRT-PCR). Next, we used loss- and gain-of-function approaches to evaluate the effect of circFOXO3 on GBM cell proliferation and invasion. Mechanistically, fluorescent in situ hybridization, RNA pull-down, dual luciferase reporter, and RNA immunoprecipitation assays were performed to confirm the interaction between circFOXO3 and miR-138-5p/miR-432-5p in GBM. An animal model was used to verify the in vitro experimental findings.ResultsCircFOXO3 expression was significantly higher in GBM tissues than in noncancerous tissues. GBM cell proliferation and invasion were reduced by circFOXO3 knockdown and enhanced by circFOXO3 overexpression. Further biochemical analysis showed that circFOXO3 exerted its pro-tumorigenic activity by acting as a competing endogenous RNA (ceRNA) to increase expression of nuclear factor of activated T cells 5 (NFAT5) via sponging both miR-138-5p and miR-432-5p. Notably, tumor inhibition by circFOXO3 downregulation could be reversed by miR-138-5p/miR-432-5p inhibitors in GBM cells. Moreover, GBM cells with lower circFOXO3 expression developed less aggressive tumors in vivo.ConclusionsOur data demonstrate that circFOXO3 can exert regulatory functions in GBM and that ceRNA-mediated microRNA sequestration might be a potential strategy for GBM therapy.
Recruit fitness and police academy performance: a prospective validation study
Authors: Korre M , Loh K , Eshleman E J , Lessa F S , Porto L G , Christophi C A , Kales S N 
Published: July 2019

AbstractBackgroundPolice academies need fit recruits to successfully engage in training activities. In a previous retrospective study, we documented that recruits with poor fitness at entry to the academy had significantly lower graduation rates, and we also suggested evidence-based entry-level fitness recommendations.AimsTo validate our findings in a prospective cohort of police recruits.MethodsRecruits entering Massachusetts municipal police academies during 2015–16 were followed prospectively until they dropped out, failed or successfully graduated their academy classes. Entry-level fitness was quantified at the start of each training class using: body composition, push-ups, sit-ups, sit-and-reach and 1.5-mile run time. The primary outcome of interest was the odds of failure (not successfully graduating from an academy). We used logistic regression to assess the probability of not graduating, based on entry-level fitness.ResultsOn average, successful graduates were leaner and possessed better overall entry-level fitness. After adjusting for age, gender and body mass index, several fitness measures were strongly associated with academy failure: fewer sit-ups completed (OR 9.6 (95% CI 3.5–26.3) (≤15 versus 41–60)); fewer push-ups completed (OR 6.7 (95% CI 2.5–17.5) (≤20 versus 41–60)); and slower run times (OR 18.4 (95% CI 6.8–50.2) (1.5 miles in > 15 min 20 s versus 10 min 37 s to 12 min 33 s)). The prospective study results supported previously suggested minimum entry-level fitness (95% graduation rate) and target (98% graduation rate) recommendations.ConclusionsPush-ups completed and 1.5-mile run time at police academy entry were successfully validated as predictors of successful academy graduation, while sit-ups were also a strong independent predictor in the prospective study.
Evolution of Lineage-Specific Gene Networks Underlying the Considerable Fruit Shape Diversity in Persimmon
Authors: Maeda Haruka , Akagi Takashi , Onoue Noriyuki , Kono Atsushi , Tao Ryutaro 
Published: July 2019

AbstractThe shapes of plant organs reflect the evolution of each lineage and have been diversified according to lineage-specific adaptations to environment. Research on the molecular pathways responsible for organ shapes has traditionally been focused mainly on leaves or flowers. Thus, little is known about the pathways controlling fruit shapes, despite their diversity in some plant species. In this study, we analyzed oriental persimmon (Diospyros kaki), which exhibits considerable diversity in fruit shapes among cultivars, to elucidate the underlying molecular mechanism using transcriptomic data and quantitative evaluation. First, to filter the candidate genes associated with persimmon fruit shapes, the whole gene expression patterns obtained using mRNA-Seq analysis from 100 individuals, including a segregated population and various cultivars, were assessed to detect correlations with principal component scores for fruit shapes characterized with elliptic Fourier descriptors. Next, a gene co-expression network analysis with weighted gene co-expression network analysis (WGCNA) package revealed that class 1 KNOX family genes and SEEDSTICK function as integrators along with some phytohormone-related genes, to regulate the fruit shape diversity. On the other hand, the OVATE family genes also contribute to fruit shape diversity, of which pathway would be potentially shared with other plant species. Evolutionary aspects suggest that acquisition of a high lineage-specific and variable expression of class 1 KNOX gene, knotted-like homeobox of Arabidopsis thaliana 1 (KNAT1), in young fruit is important for establishing the persimmon-specific mechanism that determines fruit shape diversity.