bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nahrung als Entzündungsmotor
Authors: Koch Simone 
Published: July 2019

SummaryAutoimmunerkrankungen stehen in engem Zusammenhang mit einer proinflammatorischen Ernährung, unter anderem durch zunehmende Durchlässigkeit des Darms und Aktivierung seines Immunsystems. Alkohol, Gluten, Histamin und Omega-6-Fettsäuren zählen zu den wichtigsten Entzündungstriggern und verursachen neben körperlichen auch psychische Symptome bis hin zu Depression und Angstzuständen. Mit achtwöchiger Restriktionsdiät, gefolgt von einer stufenweisen Wiedereinführung von Nahrungsmitteln können Verursacher identifiziert und bei unklaren immunologischen und psychischen Geschehen überraschende Verbesserungen erzielt werden, wie ein Fallbeispiel verdeutlicht.
Metabolomics in the Diagnosis of Pheochromocytoma and Paraganglioma
Authors: Dwight Trisha , Kim Edward , Novos Talia , Clifton-Bligh Roderick J. 
Published: July 2019

AbstractMetabolomics refers to the detection and measurement of small molecules (metabolites) within biological systems, and is therefore a powerful tool for identifying dysfunctional cellular physiologies. For pheochromocytomas and paragangliomas (PPGLs), metabolomics has the potential to become a routine addition to histology and genomics for precise diagnostic evaluation. Initial metabolomic studies of ex vivo tumors confirmed, as expected, succinate accumulation in PPGLs associated with pathogenic variants in genes encoding succinate dehydrogenase subunits or their assembly factors (SDHx). Metabolomics has now shown utility in clarifying SDHx variants of uncertain significance, as well as the accurate diagnosis of PPGLs associated with fumarate hydratase (FH), isocitrate dehydrogenase (IDH), malate dehydrogenase (MDH2) and aspartate transaminase (GOT2). The emergence of metabolomics resembles the advent of genetic testing in this field, which began with single-gene discoveries in research laboratories but is now done by standardized massively parallel sequencing (targeted panel/exome/genome testing) in pathology laboratories governed by strict credentialing and governance requirements. In this setting, metabolomics is poised for rapid translation as it can utilize existing infrastructure, namely liquid chromatography-tandem mass spectrometry (LC-MS/MS), for the measurement of catecholamine metabolites. Metabolomics has also proven tractable to in vivo diagnosis of SDH-deficient PPGLs using magnetic resonance spectroscopy (MRS). The future of metabolomics – embedded as a diagnostic tool – will require adoption by pathologists to shepherd development of standardized assays and sample preparation, reference ranges, gold standards, and credentialing.
Synthesis of Phosphaproline Derivatives: A Short Overview
Authors: Gazizov Almir S. , Smolobochkin Andrey V. , Turmanov Rahimjan A. , Pudovik Michail A. , Burilov Alexander R. , Sinyashin Oleg G. 
Published: July 2019

Pyrrolidine-based phosphonates, analogues of the natural amino acid proline, possess a diverse set of biological activity. The goal of this short review is to summarize the major developments in the synthesis of phosphaproline derivatives reported since 2004 with special emphasis on the mechanisms and limitations of the methods presented.1	Introduction2	Phosphorylation of Pyrrolidine Derivatives2.1	Syntheses via Pudovik Reaction2.2	Syntheses via Arbuzov Reaction2.3	Decarboxylative Phosphorylation of Proline2.4	Direct C–H Bond Phosphorylation2.5	Other Reactions2.6	Overview of Phosphorylation Methods3	Synthesis of 2-Phosphorylpyrrolidines from Acyclic Precursors3.1	Cyclization of 4-Substituted Butylamine Derivatives3.2	[3+2]-Dipolar Cycloaddition of α-Iminophosphonates3.3	Cyclization of Aminoalkynes and 4-Aminocarbonyl Compounds4	Conclusions
Massive Thymic Hyperplasia Mimicking Anterior Mediastinal Neoplasia in Occult Graves' Disease
Authors: Kennedy Christopher James , Paton David James William 
Published: July 2019

Background Thymic hyperplasia is a recognized complication of Graves' disease that can present radiologically as an anterior mediastinal mass.
Case Description We present a unique case of massive thymic hyperplasia occurring in a 24-year-old female without a known history of thyroid or other systemic disease in whom Graves' disease first manifested intraoperatively during thymectomy for presumed neoplasia.
Conclusion We suggest that the work-up of all anterior mediastinal masses should include a comprehensive search for medical causes of reversible thymic enlargement.
Effect of Injectable Platelet-Rich Fibrin on Diced Cartilage's Viability in Rhinoplasty
Authors: Gode Sercan , Ozturk Arin , Berber Veysel , Kısmalı Erkan 
Published: July 2019

AbstractDiced cartilage is one of the most widely used camouflage technique in rhinoplasty. Its variable resorption rate creates issues in postoperative time period. Platelet-rich fibrin is an autologous concentrated blood derivative containing growth factors that accelerate tissue healing. The authors evaluate the effect of injectable platelet-rich fibrin (I-PRF) on the viability of diced cartilage, which has been used for dorsum camouflage in rhinoplasty. Forty patients were randomly divided into two groups based on dorsal camouflage grafts: diced cartilage with I-PRF (study group) and diced cartilage without I-PRF (control group). Cartilage graft thickness was measured by linear superficial tissue ultrasound at the postoperative first week and the third month in both groups. The mean cartilage graft thickness loss between the first-week and third-month ultrasound measurements was 0.58 ± 0.21 mm in the study group and 0.82 ± 0.35 mm in the control group. There was significant volume loss in the control group. I-PRF was successful in reducing the resorption rate of diced cartilage on nasal dorsum by either increasing the viability or keeping its form. Sticky cartilage is an easily applicable and reliable technique that may be used to camouflage dorsal irregularities in rhinoplasty.
The Effect of Platelet-Rich Fibrin on Nasal Skin Thickness in Rhinoplasty
Authors: Gode Sercan , Ozturk Arin , Kısmalı Erkan , Berber Veysel , Turhal Goksel 
Published: July 2019

AbstractThe study hypothesized the potential positive effects of platelet-rich fibrin (PRF) in postoperative rhinoplasty patients, such as better wound healing, less dead space, and less edema. The authors assessed PRF for nasal dorsum camouflage and studied its potential effects on nasal dorsal skin in rhinoplasty. Thirty-eight patients who underwent open approach primary rhinoplasty were categorized into two groups: nasal dorsal PRF group and control group. PRF membrane was used for nasal dorsum camouflage and laid over the bony dorsum and cartilage framework of the supratip area. Skin and subcutaneous soft tissue thickness were measured by linear superficial tissue ultrasound at the pre- and postoperative first week and the third month in both groups. Mean skin thickness over the supratip area was significantly higher in the control group in the first-week control. There were no significant differences in both first-week and third-month controls' nasal dorsum mean skin thickness measurements between the two groups. Regarding PRF complications, we encountered no complications in either group, including scarring, hematoma, infection, skin discoloration, and acne. The authors present the application of PRF membrane over the bony dorsum and cartilage framework of the supratip area. They observed its positive effect on postoperative edema, especially in the early postoperative period. Long-term investigations have to be performed to evaluate its potential effect on the rhinoplasty procedure. This was a level of evidence 3 study.
Enhancement of the sensitivity of the light-induced drift effect to interatomic interaction potentials using a mixture of two buffer gases
Authors: Parkhomenko A.I. , Shalagin A.M. 
Published: July 2019

Abstract
Based on five different nonempirical (calculated ab initio) interaction potentials for pairs of colliding Li – Ne particles and three different interaction potentials for pairs of colliding Li – Ar particles, we have theoretically investigated the spectral features of the light-induced drift (LID) rate of Li atoms in the buffer Ne gas in a mixture of buffer Ne + Ar gases. The calculations of LID of Li atoms in the buffer Ne gas for two interaction potentials predict anomalous LID and, as a result, strong sensitivity of the spectral shape of the LID lines to the differences in these potentials. For three other potentials (out of the five in question), the shape of the LID line of Li atoms in Ne is insensitive to the shape of the potential, since calculations with these potentials predict a normal LID effect. In this case, as it turned out, by adding a small fraction (approximately 10 %) of Ar to Ne, one can go from normal LID to anomalous LID and thereby radically increase the sensitivity of the LID line shape of Li atoms to the difference in these interaction potentials. The results obtained enable high-precision testing of the interatomic interaction potentials in experiments on anomalous LID.
Analysis of the use of the LCR circuit model for evaluating the resonant response of thin rectangular nanoantennas
Authors: Venediktov V.Yu. , Efremova E.A. , Krylov I.R. , Prokhorova U.V. 
Published: July 2019

Abstract
We demonstrate the possibility of estimating in a simple way the expected frequency of the resonant response to an external electromagnetic field in a thin golden nanoantenna having a rectangular cross section. The paper considers nanoantennas with a thickness smaller than the thickness of the skin layer or comparable with it. Analytical expressions for estimating the resonance response are presented, and full-wave simulation is performed. The algorithm for obtaining such estimates is important, in particular, for planning experiments without using full-wave simulation, which is often rather resource consuming. To obtain analytical expressions, a refined LCR circuit model is used. The analytical estimates obtained for the characteristics of the resonant response are in good agreement with the results of the full-wave simulation.
Symmetric nanostructuring and plasmonic excitation of gold nanostructures by femtosecond Laguerre – Gaussian laser beams
Authors: Busleev N.I. , Kudryashov S.I. , Danilov P.A. , Porfir’ev A.P. , Saraeva I.N. , Rudenko A.A. , Umanskaya S.F. , Zayarnyi D.A. , Ionin A.A. , Khonina S.N. 
Published: July 2019

Abstract
Femtosecond low-energy Laguerre – Gaussian pulses of tightly focused visible laser radiation were employed for single-pulse ablative nanostructuring of a 50-nm thick gold film. Similar pulses of lower energy were employed for the efficient plasmonic photoluminescence excitation of a rhodamine 6G dye monolayer in the fabricated nanostructures. The consistency between the shape and polarisation symmetries of the low-energy laser beam, on the one hand, and the gold nanostructures produced by the same beam at a high radiation energy, on the other hand, opens the way to consistent nanostructuring and surface-enhanced analytical spectroscopy with the use of nanostructures.
Spontaneous phase symmetry breaking in a gas coupled-cavity ring laser
Authors: Zolotoverkh I.I. , Lariontsev E.G. 
Published: July 2019

Abstract
A theoretical model is proposed that describes the lasing dynamics in a gas ring laser (GRL) with coupled cavities. The conditions are found under which spontaneous phase symmetry of counterpropagating waves is broken in the GRL with an antiphase optical coupling of the cavities. It is shown that in the case of spontaneous phase symmetry breaking, two branches appear on the GRL frequency characteristic. In some region of frequency nonreciprocity of a ring cavity, both branches can exist under the same conditions. In this case, radiation bistability appears in the GRL, and hysteresis phenomena can be observed.
Laser detection of nuclear spin isomers of ethylene molecules
Authors: Chapovsky P.L. 
Published: July 2019

Abstract
We report the making of a double-beam laser spectrometer to measure absorption spectra in the ν
5 + ν
9 combination vibrational band of ethylene in the region of λ = 1.6 μm. The spectrometer is used to find a portion of the spectrum that has well-resolved absorption lines of all four nuclear spin isomers of ethylene molecules. The rotational quantum numbers of these absorption lines and the nuclear spin isomers of ethylene molecules responsible for them are identified.
Evaluation of oxygenation in the surface layers of biological tissues based on diffuse optical spectroscopy with automated calibration of measurements
Authors: Kleshnin M.S. , Turchin I.V. 
Published: July 2019

Abstract
To assess the oxygen saturation (oxygenation) in the surface layers of biological tissues (at a depth of 4 mm), a compact system based on diffuse optical spectroscopy (DOS) with reflective measurement geometry in the wavelength range of 520 – 590 nm is proposed. The experimental DOS device is based on a broadband LED source of probe radiation and a spectrometer using a fibre-optic radiation delivery system. To calculate the oxygenation, an original method is proposed based on measuring the intensity of scattered light at four different locations of the source and receiver on the surface of the object under study (four-measurement method). The developed method allows for the device hardware parameters (optical contact with the tissue, transient characteristics of the radiation delivery system) and does not require any additional calibration measurements. The results of testing the DOS system using the four-measurement method for monitoring the oxygen saturation of tissues during the artificial occlusion of the blood vessels agree with the published data of other research teams.
Study on harmonic generation regimes of Raman dissipative solitons in an external fibre cavity in a spectral region of 1.3 μm
Authors: Kharenko D.S. , Efremov V.D. , Babin S.A. 
Published: July 2019

Abstract
We have studied the harmonic generation regimes in a pulsed SRS laser with synchronous pumping. The use of phosphosilicate polarisation-maintaining fibre made it possible to obtain stable generation of Raman dissipative solitons (RDS’s) with a wavelength of 1.3 μm, and a fold increase in the length of the external cavity relative to that of the pump laser cavity by a dispersion-shifted fibre allowed us to raise the threshold for the transition to noise-like pulses and to increase the RDS energy up to 2.5 nJ with an estimated duration of a transform-limited pulse of about 200 fs.
Temporal patterns in multi-modal social interaction between elderly users and service robot
Authors: Wang Ning , Di Nuovo Alessandro , Cangelosi Angelo , Jones Ray 
Published: July 2019

Abstract
Social interaction, especially for older people living alone is a challenge currently facing human-robot interaction (HRI). There has been little research on user preference towards HRI interfaces. In this paper, we took both objective observations and participants’ opinions into account in studying older users with a robot partner. The developed dual-modal robot interface offered older users options of speech or touch screen to perform tasks. Fifteen people aged from 70 to 89 years old, participated. We analyzed the spontaneous actions of the participants, including their attentional activities and conversational activities, the temporal characteristics of these social behaviours, as well as questionnaires. It has been revealed that social engagement with the robot demonstrated by older people was no different from what might be expected towards a human partner. This study is an early attempt to reveal the social connections between human beings and a personal robot in real life.
Opioid use Patterns and Risk Characteristics among Injured Patients
Authors: Cochran Gerald , Pacella Maria L. , Ringwald Whitney , Repine Melissa , Hruschak Valerie , Beaugard Corinne , Sewall Craig , Rosen Danny , Alarcon Louis H. , Tarkin Ivan S. , Moloney Gele B. , Corcos Alain 
Published: July 2019

Background Injured patients are at risk for prolonged opioid use after discharge from care. Limited evidence exists regarding how continued opioid use may be related to opioid medication misuse and opioid use disorder (OUD) following injury. This pilot study characterized opioid consumption patterns, health characteristics, and substance use among patients with active prescriptions for opioid medications following injury care. Methods This study was a cross-sectional screening survey combined with medical record review from February 2017 to March 2018 conducted among outpatient trauma and orthopedic surgery clinic patients. Eligible patients were 18–64 years of age, admitted/discharged for an injury or trauma-related orthopedic surgery, returning for clinic follow-up ≤6 months post hospital discharge after the index injury, prescribed opioid pain medication at discharge, and currently taking an opioid medication (from discharge or a separate prescription post discharge). Data collected included demographic, substance use, mental health, and physical health information. Descriptive and univariate statistics were calculated to characterize the population and opioid-related risks. Results Seventy-one participants completed the survey (92% response). Most individuals (≥75%) who screened positive for misuse or OUD reported no nonmedical/illicit opioid use in the year before the index injury. A positive depression screen was associated with a 3.88 times increased likelihood for misuse or OUD (95% confidence interval [CI] = 1.1–13.5). Nonopioid illicit drug use (odds ratio [OR] = 1.89, 95% CI = 1.1–3.4) and opioid craving (OR = 1.29, 95% CI = 1.1–1.5) were also associated with increased likelihood for misuse or OUD. Number of emergency department visits in the 3 years previous to the index injury was associated with a 22% likelihood of being misuse or OUD positive (95% CI = 1.0–1.5). Conclusions Patients with behavioral health concerns and greater emergency department utilization may have heightened risk for experiencing adverse opioid-related outcomes. Future research must further establish these findings and possibly develop protocols to identify patients at risk prior to pain management planning.
Search for power-efficient wide-range reversible resistance modulation of VO2 single crystals
Authors: Fisher Bertina , Patlagan Larisa , Kornblum Lior 
Published: July 2019

Abstract
The abrupt metal insulator transition in VO2 is attracting considerable interest from both fundamental and applicative angles. We report on DC I–V characteristics measured on VO2 single crystals in the two-probe configuration at several ambient temperatures below the insulator–metal (I–M) transition. The insulator-mixed-metal-insulator transition is induced by Joule heating above ambient temperature in the range of negative differential resistivity (NDR). In this range the stability of I(V) is governed by the load resistance RL. Steady state I(V) is obtained for R
L  >  |dV/dI|max in the NDR regime. For R
L  <  |dV/dI|max there is switching between initial and final steady states associated with peaks in the Joule power, that are higher the lower R
L is. The peaks caused by steep switching are superfluous and damaging the samples. On the other hand, the large R
L needed for steady state is the main power consumer in the circuit at high currents. The present work is motivated by the need to avoid damaging switching in the NDR regime while reducing the power consumption in the circuit. Large resistance modulation can be obtained under steady state conditions with reduced power consumption by increasing the ambient temperature of the device above room temperature. Under steady state conditions, the transition to the mixed metal-insulator state is smooth and is followed closely by appearance of sliding domains.
Space charge-limited current transport in thin films of alkyl-functionalized silicon nanocrystals
Authors: Pfaehler Simon , Angı Arzu , Chryssikos Domenikos , Cattani-Scholz Anna , Rieger Bernhard , Tornow Marc 
Published: July 2019

Abstract
We describe the fabrication and electrical characterization of all-silicon electrode devices to study the electronic properties of thin films of silicon nanocrystals (SiNCs). Planar, highly doped Si electrodes with contact separation of 200 nm were fabricated from silicon-on-insulator substrates, by combination of electron beam lithography and reactive ion etching. The gaps between the electrodes of height 110 nm were filled with thin-films of hexyl functionalized SiNCs (diameter 3 nm) from colloidal dispersions, via a pressure-transducing PDMS (polydimethylsiloxane) membrane. This novel approach allowed the formation of homogeneous SiNC films with precise control of their thickness in the range of 15–90 nm, practically without any voids or cracks. The measured conductance of the highly resistive SiNC films at high bias voltages up to 60 V scaled approximately linearly with gap width (5–50 μm) and gap filling height, with little device-to-device variance. We attribute the observed, pronounced hysteretic current–voltage (I–V) characteristics to space-charge-limited current transport, which—after about twenty cycles—eventually blocks the current almost completely. We propose our all-silicon device scheme and gap filling methodology as a platform to investigate charge transport in novel hybrid materials at the nanoscale, in particular in the high resistivity regime.
The relationship between ACTN3 gene polymorphism with VO2 max and flexibility
Authors: Candrawati Susiana , Gumilas Nur S A , Rujito Lantjip , Ardiansyah Irfani R 
Published: July 2019

Abstract
Maximum oxygen consumption (VO2 max) and flexibility are essential biomotoric components for football athletes. The influence of genetics on the biomotoric element has not been widely studied. The ACTN3 gene probably affects VO2 max and flexibility. This study aims to determine the relationship between ACTN3 gene polymorphism to VO2 max and flexibility in students of UKM Olahraga Jenderal Soedirman University. This was an observational analytic study with a cross-sectional approach. Seventy-eight subjects chosen by consecutive sampling underwent the protocol study. Venous blood samples were taken for ACTN3 gene polymorphism examination. The respondents were also tested for VO2 max with the multi-stage fitness test and flexibility tests using sit and reach method. Data were analyzed by a one way ANOVA test with a significance level of p=0.05.The results of this study showed that there was no significant relationship between ACTN3 gene polymorphism with VO2 max (p=0.763) and flexibility (p=0.912). The highest mean VO2 max was in the RR genotype (35.25±7.15 ml/kg.min), while the highest mean of flexibility was in the XX genotype (37.02±7.89 cm). There was no relationship between ACTN3 gene polymorphism with VO2 max and flexibility, in students of Jenderal Soedirman University.
Hepatitis B as hepatocellular carcinoma (HCC) risk factor in the south region of Java, Indonesia
Authors: Gumilas Nur Signa A , Harini Ika M , Sylviningrum Thianty , Djatmiko Wahyu , Rujito Lantip 
Published: July 2019

Abstract
Hepatocellular carcinoma (HCC) is a liver cancer caused by uncontrolled growth of hepatocytes. Many factors relate to the incidence of hepatocellular carcinoma whether it is internal or external factors. This study aimed to determine the risk factors of HCC South Region of Central Java, Indonesia. The study design used a case-control approach using the population of HCC patients from Margono Soekarjo Banyumas Hospital as a referring hospital in a Southern part of Central Java. Samples were considered as total sampling criteria using patient’s database from the hospital. Statistical analysis was Chi-square and Fisher test. The study found that the age and hepatitis B infection have an association with the prevalence of HCC. Individuals infected with hepatitis B were at higher risk of HCC, compared with individuals not infected with hepatitis B. Younger age was a protective factor against HCC. As a conclusion, there was a significant relationship between age and hepatitis B infection with HCC.