bluuebunny/crossref_metadata_2025_split huggingface dataset:
The advanced glycation end‐product Nϵ‐carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes‐associated risk and its prevention
Authors: Menini Stefano , Iacobini Carla , de Latouliere Luisa , Manni Isabella , Ionta Vittoria , Blasetti Fantauzzi Claudia , Pesce Carlo , Cappello Paola , Novelli Francesco , Piaggio Giulia , Pugliese Giuseppe 
Published: March 2018

AbstractDiabetes is an established risk factor for pancreatic cancer (PaC), together with obesity, a Western diet, and tobacco smoking. The common mechanistic link might be the accumulation of advanced glycation end‐products (AGEs), which characterizes all of the above disease conditions and unhealthy habits. Surprisingly, however, the role of AGEs in PaC has not been examined yet, despite the evidence of a tumour‐promoting role of receptor for advanced glycation end‐products (RAGE), the receptor for AGEs. Here, we tested the hypothesis that AGEs promote PaC through RAGE activation. To this end, we investigated the effects of the AGE Nϵ‐carboxymethyllysine (CML) in human pancreatic ductal adenocarcinoma (PDA) cell lines and in a mouse model of Kras‐driven PaC interbred with a bioluminescent model of proliferation. Tumour growth was monitored in vivo by bioluminescence imaging and confirmed by histology. CML promoted PDA cell growth and RAGE expression, in a concentration‐dependent and time‐dependent manner, and activated downstream tumourigenic signalling pathways. These effects were counteracted by RAGE antagonist peptide (RAP). Exogenous AGE administration to PaC‐prone mice induced RAGE upregulation in pancreatic intraepithelial neoplasias (PanINs) and markedly accelerated progression to invasive PaC. At 11 weeks of age (6 weeks of CML treatment), PaC was observed in eight of 11 (72.7%) CML‐treated versus one of 11 (9.1%) vehicle‐treated [control (Ctr)] mice. RAP delayed PanIN development in Ctr mice but failed to prevent PaC promotion in CML‐treated mice, probably because of competition with soluble RAGE for binding to AGEs and/or compensatory upregulation of the RAGE homologue CD166/ activated leukocyte cell adhesion molecule, which also favoured tumour spread. These findings indicate that AGEs modulate the development and progression of PaC through receptor‐mediated mechanisms, and might be responsible for the additional risk conferred by diabetes and other conditions characterized by increased AGE accumulation. Finally, our data suggest that an AGE reduction strategy, instead of RAGE inhibition, might be suitable for the risk management and prevention of PaC. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Polydrug epidemiology: Benzodiazepine prescribing and the drug overdose epidemic in the United States
Authors: Zoorob Michael James 
Published: March 2018

AbstractBackgroundAlthough polydrug incidents comprise a substantial proportion of overdose deaths, scholarly and popular focus has centered on prescription opiates. This study examines the role of benzodiazepine and opioid prescriptions on overdose—both individually and synergistically—using data from Medicare Part D, a source of prescription drug claims for about 35 million Americans.MethodsPrescribing data from the Medicare Part D Public Use Files for 2013, 2014, and 2015 (approximately 3.5 billion prescription drug claims) are geolocated using the prescriber's national provider identifier to calculate the proportion of claims for opioids and benzodiazepines in each county. These rates are matched with overdose data and controls to compile an analytic dataset of 9105 county‐years. Multinomial logistic regression is used to estimate the probability that a county experiences higher rates of overdose fatalities.ResultsA 1% increase in the benzodiazepine proportion of claims is associated with 1.2 odds of high, versus low, overdose (P < .1) and 1.4 odds of very high overdose (P < .05). Moreover, there was a substantial interaction between opioids and benzodiazepines (P < .001). A county with 6% benzodiazepine prescriptions and 12% opioid prescriptions has a .58 predicted probability of very high overdose, significantly higher (P < .001) than the .33 probability for a county with 12% opioid prescriptions but 3% benzodiazepine prescriptions.ConclusionThese findings shed light on the polydrug epidemiology of the overdose epidemic. Overdose deaths are highest where elevated opioid and benzodiazepine claims coexist. Overdose levels may reflect polydrug use and misuse, requiring clinical and policy responses beyond reducing opioid prescriptions.
Functional dendrimer–gold nanoparticle hybrids for biomedical applications
Authors: Li Xiaojie , Kono Kenji 
Published: March 2018

AbstractDendrimers are a class of nano‐sized synthetic polymers with a well‐defined composition and regularly branched tree‐like structure produced by stepwise growth. The uniform size, globular shape and tunable surface chemistry make dendrimers versatile nanoscaffolds to encapsulate or stabilize various inorganic (metal, metal oxide, semiconductor) nanoparticles. In the past decade, research interest in dendrimer–inorganic nanoparticle hybrids has evolved from the development of interesting properties to the exploitation of advanced and useful functions. In particular, because gold nanoparticles with controlled morphology and optical properties have been demonstrated to be promising and versatile candidates for a diverse field of biomedical applications including sensing, in vitro and in vivo imaging, drug delivery, diagnostics and therapies, dendrimer–gold nanoparticle hybrids with biocompatibility have recently been intensively investigated for promising biomedical applications due to their controllable structures and dimensions, as well as their desirable internal and/or external functionalities. In this review, we discuss the recent progress regarding the development of functional dendrimer–gold nanoparticle hybrids for biomedical applications. The strategies for the fabrication of various structures of dendrimer–gold nanoparticle hybrids will first be summarized, followed by their biomedical applications in drug and gene delivery, photothermal therapy and combined therapies. © 2018 Society of Chemical Industry
Anionic ring‐opening polymerization of N‐glycidylphthalimide: Combination of phosphazene base and activated monomer mechanism
Authors: Rassou Somasoudrame , Illy Nicolas , Tezgel Ozgul , Guégan Philippe 
Published: March 2018

ABSTRACTAnionic ring‐opening polymerization of glycidyl phthalimide, initiated with alcohol–phosphazene base systems and based on monomer activation with a Lewis acid (iBu3Al), has been studied. No propagation occurred for initiator: iBu3Al ratios less or equal to 1:3. For larger Lewis acid amounts, the first anionic ring‐opening polymerizations of glycidyl phthalimide were observed. Polymers were carefully characterized by NMR, MALDI‐TOF mass spectrometry, and size exclusion chromatography and particular attention was given to the detection of eventual transfer or side‐reactions. However, polymer precipitation and transfer reaction to aluminum derivative were detrimental to monomer conversion, polymerization control, and limited polymer chain molar masses. The influence of reaction temperature and solvent on polymer precipitation and transfer reactions was studied and reaction conditions have been optimized leading to afford end‐capped poly(glycidyl phthalimide) with narrow molar mass distributions. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1091–1099
Sustainable, fire‐resistant phthalonitrile‐based glass fiber composites
Authors: Laskoski Matthew , Shepherd Arica R. , Mahzabeen Wadia , Clarke Jadah S. , Keller Teddy M. , Sorathia Usman 
Published: March 2018

ABSTRACTThe sustainable resveratrol‐based phthalonitrile was used in the preparation of E‐glass fiber‐reinforced phthalonitrile composite panels fabricated by hot pressed prepreg consolidation with bis[4‐(3‐aminophenoxy)phenyl]sulfone (m‐BAPS) as the curing additive. This amorphous monomer exhibited excellent viscosities at temperatures below 200 °C, which is applicable to standard processing conditions. Rheometric measurements were used to evaluate the cure of the composite as a function of the postcure conditions. The composite retains >95% of its room temperature storage modulus up to 450 °C based on these postcuring parameters. More importantly, flammability performance of the composite—which was determined in terms of ignitability, heat release, and mass loss rate—excels over other state‐of‐the‐art polymer/glass composites. Even under the most extreme heat fluxes (e.g., 100 kW⋅m−2), the composite performs exceptionally well suggesting that resveratrol‐based phthalonitrile composites can be used in fire‐resistant applications. Published 2018.† J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1128–1132
D‐π‐a‐type oxime sulfonate photoacid generators for cationic polymerization under UV–visible LED irradiation
Authors: Jin Ming , Zhou Ruchun , Yu Man , Pan Haiyan , Wan Decheng 
Published: March 2018

ABSTRACTFour D‐π‐A‐type nonionic oxime sulfonate photoacid generators (PAGs) have been designed and synthesized for use in light‐emitting diode (LED) excitable cationic photoinitiators, in which N,N‐diphenylamino was used as electron donor with trifluoroacetophenone‐based oxime sulfonates (trifluoromethanoesulfonate and p‐toluenesulfonate) as electron acceptor and substituted fluorene and biphenyl groups as the π‐conjugated systems. PAG‐Ben‐Tol (with biphenyl and p‐toluenesulfonate) and PAG‐Flu‐Tol (with fluorene and p‐toluenesulfonate) showed high quantum yields of photoacid generation (0.33–0.50) and very good thermal stability (over 250 °C). The absorbance spectra of these PAGs were consistent with the emission spectra of commercially gained UV–visible LED light sources. The potential of these PAGs for cationic photoinitiators was tested in two cationic monomer systems. These PAGs needed low light intensity and low concentration for photopolymerization with high conversions of monomer, for example, over 80%, gained at 3.0 mW cm−2 from 365 to 470 nm LEDs. The photochemical mechanisms of these PAGs are comprehensively investigated and discussed in detail. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1146–1154
Ozone disinfection of home nebulizers effectively kills common cystic fibrosis bacterial pathogens
Authors: Towle Dana , Baker Vanisha , Schramm Craig , O'Brien Matthew , Collins Melanie S. , Feinn Richard , Murray Thomas S. 
Published: March 2018

AbstractObjectiveThe Cystic Fibrosis Foundation (CFF) recommends routine nebulizer disinfection for patients but compliance is challenging due to the heavy burden of home care. SoClean® is a user friendly ozone based home disinfection device currently for home respiratory equipment. The objective of this study was to determine whether SoClean® has potential as a disinfection device for families with CF by killing CF associated bacteria without altering nebulizer output.HypothesisOzone based disinfection effectively kills bacterial pathogens inoculated to home nebulizer equipment without gross changes in nebulizer function.Study DesignCommon bacterial pathogens associated with CF were inoculated onto the PariLC® jet nebulizer and bacterial recovery compared with or without varied ozone exposure. In separate experiments, nebulizer output was estimated after repeated ozone exposure by weighing the nebulizer.ResultsOzone disinfection was time dependent with a 5 min infusion time and 120 min dwell time effectively killing >99.99% bacteria tested including Pseudomonas aeruginosa and Staphylococcus aureus. Over 250 h of repeat ozone exposure did not alter nebulizer output. This suggests SoClean® has potential as a user‐friendly disinfection technique for home respiratory equipment.
MiR‐206 inhibits proliferation and migration of prostate cancer cells by targeting CXCL11
Authors: Wang Yao , Xu Haitao , Si Lihui , Li Qiuju , Zhu Xiujie , Yu Tong , Gang Xiaokun 
Published: March 2018

BackgroundOur study was aimed at detecting the expression levels of miR‐206 in prostate cancer (PCa) tissues and PCa cell lines, and exploring the potential functions of miR‐206 by targeting chemokine ligand 11 (CXCL11).MethodsRT‐qPCR was applied to detect the expressions of miR‐206 and CXCL11 in PCa tissues and in PCa cell lines. Expression of the CXCL11 protein was detected using Western blot. After manipulating the expression of miR‐206 and CXCL11 in PC‐3 and DU‐145 cells, the changes of cell proliferation and cell cycle were observed through cell counting kit‐8 (CCK‐8) and flow cytometry. Wound healing and transwell assay were conducted for cell migration and invasion examination in vitro. The luciferase reporter assay was applied to validate the association between miR‐206 and CXCL11.ResultsMiR‐206 was significantly under‐expressed in PCa tissues and in PCa cell lines. Up‐regulation of miR‐206 could inhibit proliferation, migration, invasion and induced G1/G0 arrest of PCa cells, and vice versa. MiR‐206 bound to the 3′‐UTR of CXCL11 and significantly repressed the luciferase activity. Overexpression of miR‐206 decreased the expression level of CXCL11 significantly. CXCL11 mRNA and protein levels were significantly decreased in PCa cells. Downregulation of CXCL11 presented tumor‐suppressing effects on PCa cells as miR‐206 mimics did. And co‐transfection miR‐206 attenuated the tumor‐promoting effects induced by CXCL11 overexpression.ConclusionOur current finding demonstrated that miR‐206 negatively regulated PCa cell proliferation and migration, and arrested cell cycle by targeting CXCL11 as a tumor suppressor in prostate cancer.
Spray droplet size and carrier volume effect on dicamba and glufosinate efficacy
Authors: Butts Thomas R , Samples Chase A , Franca Lucas X , Dodds Darrin M , Reynolds Daniel B , Adams Jason W , Zollinger Richard K , Howatt Kirk A , Fritz Bradley K , Clint Hoffmann Wesley , Kruger Greg R 
Published: March 2018

AbstractBACKGROUNDPesticide applications using a specific droplet size and carrier volume could maximize herbicide efficacy while mitigating particle drift in a precise and efficient manner. The objectives of this study were to investigate the influence of spray droplet size and carrier volume on dicamba and glufosinate efficacy, and to determine the plausibility of droplet‐size based site‐specific weed management strategies.RESULTSGenerally, across herbicides and carrier volumes, as droplet size increased, weed control decreased. Increased carrier volume (187 L ha−1) buffered this droplet size effect, thus greater droplet sizes could be used to mitigate drift potential while maintaining sufficient levels of weed control. To mitigate drift potential and achieve satisfactory weed control (≥ 90% of maximum observed control), a 900 µm (Ultra Coarse) droplet size paired with 187 L ha−1 carrier volume is recommended for dicamba applications and a 605 µm (Extremely Coarse) droplet size across carrier volumes is recommended for glufosinate applications. Although general droplet size recommendations were created, optimum droplet sizes for weed control varied significantly across site‐years.CONCLUSIONConvoluted interactions occur between droplet size, carrier volume, and other application parameters. Recommendations for optimizing herbicide applications based on droplet size should be based on a site‐specific management approach to better account for these interactions. © 2018 Society of Chemical Industry
Induction of keratinocyte migration by ECa 233 is mediated through FAK/Akt, ERK, and p38 MAPK signaling
Authors: Singkhorn Sawana , Tantisira Mayuree H. , Tanasawet Supita , Hutamekalin Pilaiwanwadee , Wongtawatchai Tulaporn , Sukketsiri Wanida 
Published: March 2018

Centella asiatica is widely considered the most important medicinal plant for treating and relieving skin diseases. Recently developed standardized extract of Centella asiatica ECa 233 has demonstrated positive effects on wound healing of incision and burn wound in rats. However, knowledge associated with wound healing mechanism of ECa 233 was scare. Therefore, this study aimed to investigate the effect and underlying molecular mechanisms of ECa 233 on the migration of a human keratinocyte cell line (HaCaT) using scratch wound healing assay. Formation of filopodia, a key protein in cell migration as well as signaling pathways possibly involved were subsequently assessed. It was found that HaCaT cell migration was significantly enhanced by ECa 233 in a concentration‐ and time‐dependent manner. The filopodia formations were accordingly increased in exposure to ECa 233 at concentrations of 0.1–100 μg/ml. Furthermore, ECa 233 was found to significantly upregulate the expression of Rac1 and RhoA and to induce phosphorylation of FAK and Akt as well as ERK and p38 MAPK. Taken all together, it is suggestive that ECa 233 induces cell migration and subsequently promotes wound healing activity, through the activation of FAK, Akt, and MAPK signaling pathways thereby supporting the role of ECa 233 to be further developed for the clinical treatment of wound.
Composite hierarchical antidisturbance control for a class of discrete‐time stochastic systems
Authors: Wei Xinjiang , Zhang Huifeng , Sun Shixiang , Karimi Hamid Reza 
Published: March 2018

SummaryIn this paper, antidisturbance control and estimation problem are discussed for a class of discrete‐time stochastic systems with nonlinearity and multiple disturbances, which include the disturbance with partially known information and a sequence of random vectors. A disturbance observer is constructed to estimate the disturbance with partially known information. A composite hierarchical antidisturbance control scheme is proposed by combining disturbance observer and H∞ control. It is proved that the 2 different disturbances can be rejected and attenuated, and the corresponding desired performances can be guaranteed for discrete‐time stochastic systems with known and unknown nonlinear dynamics, respectively. Simulation examples are given to demonstrate the effectiveness of the proposed scheme.
Reaction Tailoring for Synthesis of Phase‐Pure Nanocrystals of AgInSe2, Cu3SbSe3 and CuSbSe2
Authors: Kshirsagar Anuraj S. , Khanna Pawan. K. 
Published: March 2018

AbstractPresent article highlights synthesis of phase pure I, III, VI2 and I, V, VI2 ternary selenides nanocrystals (NCs) using oleic acid and oleyl amine capping agents. The synthesis of AgInSe2 (AISe), Cu3SbSe3 and CuSbSe2 (CSSe) NCs was executed by employing cyclohexeno‐1,2,3‐selenadiazole (SDZ) as Se precursor. The current study is the first report describing use of thermally labile organoselenium compound for the synthesis of such technologically important ternary selenide NCs. Systematic study of the formation of AISe and CSSe NCs at different reaction time is carried out in order to confirm phase purity and stoichiometry. The spherical, stoichiometric and NIR active semiconductors showed formation of orthorhombic crystal structure as confirmed from XRD analysis. It was observed that formation of phase pure AISe NCs requires 5 hours (h) of constant heating at about 220οC irrespective of the capping agents however, CuSbSe2 was obtained within an hour in presence of oleyl amine at same reaction temperature. Nanocrystals were characterized by different analytical tools such as UV‐Visible spectroscopy, FTIR, XRD, SEM/EDS, TEM, particle size and XPS analysis. Based on the results, possible chemical reaction pathway for ternary chalcogenide is presented.
Multicomponent‐Reaction‐ (MCR‐) Assisted Synthesis of a Coumarin‐Based Deep Blue Emitter for OLEDs and Related Applications
Authors: Puthumana Shyam Shankar Eramangalam , Damodaran Bahulayan 
Published: March 2018

AbstractThe lighting and display solutions of the future are Organic Light Emitting Diodes (OLEDs). For the electron transportation, hole transportation and light emission, sequential layers of specially designed organic molecules and materials are used in OLEDs. The perfect blue‐emitters showing CIE (Commission Internationale de l′Eclairage) coordinates with a y‐component smaller than 0.1 are highly desired for OLED technology. Herein we report an efficient step economic protocol for the synthesis of a deep blue emitting fluorescent molecule named as “Ugi EML BLUE” (λems 443 nm; C.I.E. X=0.162, Y=0.012; HOMO/LUMO=‐5.94 eV/‐1.60 eV) suitable for the emissive layers (EML) of OLEDs and related applications.
Evaluation of Anticancer Activity of Water‐Soluble Curcumin through the Induction of Apoptosis by p53 and p21 Modulation
Authors: Banuppriya Govindharasu , Shakambari Ganeshan , Sribalan Rajendran , Varalakshmi Perumal , Padmini Vediappen 
Published: March 2018

AbstractAmide containing water soluble curcumin derivatives were synthesized and studied for their anti‐cancer activity. The synthesized water soluble compounds were cytotoxic when tested in vitro on HeLa cell and induced a p53 mediated apoptosis as evidenced by immunoblot analysis. Further DNA binding studies were also carried out to investigate the interaction between these synthesized curcumin compounds and HS‐DNA. The binding constant values (0.8167X104 M−1of 5a, 0.5443 X103 M−1 of 5b) suggested a good binding propensity to DNA. Physical properties such as stability, solubility, and log p values were investigated for the synthesized compounds.
Selective Synthesis of Ni(II) and Pd(II) Complexes with either ‘Normal’ or ‘Abnormal’ N‐Heterocyclic Carbene Coordination Modes
Authors: Tan Kel Vin , Li Zili , Karmis Rebecca E. , Barnard Peter J. 
Published: March 2018

AbstractA family of Ni(II) and Pd(II) complexes of one bidentate and three tetradentate, N‐heterocyclic carbene (NHC) / amidate ligands have been prepared. The imidazolium salt pro‐ligands used in the synthesis of these complexes were designed to facilitate the ‘abnormal’ NHC coordination mode, through the introduction of either (1) methyl blocking group at the C2 position of the imidazolium units or (2) sterically demanding tert‐butyl imidazolium wingtip substituents or (3) the ligand was macrocyclic in nature. In all cases, the desired complexes were uncharged, with square‐planar coordination geometries about the metal centres. These studies showed that in the case of Ni(II), abnormal NHC complexes could be formed for the C2‐blocked tetradentate ligands only. In contrast for Pd(II), ‘abnormal’ NHC complexes could be prepared from C2‐blocked bidentate and tetradentate ligands with sterically demanding tert‐butyl NHC wingtip substituents. For the macrocyclic tetradentate ligand, Ni(II) and Pd(II) complexes displaying the ‘normal’ NHC coordination mode were obtained.
Building the tower without climbing it: Progress in engineering systems
Authors: Broniatowski David A. 
Published: March 2018

AbstractThe Engineering Systems (ES) movement set a research agenda that transformed the field of systems engineering. By focusing on complex sociotechnical systems, the ES movement dramatically expanded the scope of the problems that could be addressed by systems engineers, drawing young scholars into the field. ES succeeded in focusing the scholarly community around the concepts of the “ilities”—nontraditional system lifecycle properties—sociotechnical complexity, and system architecture. In this article, I review some of the progress made by scholars in the field, outline directions for future work, and identify challenges facing future progress in systems engineering. Specific attention is given to approaches that emphasize the roles of abstraction hierarchies, contextual interpretation, knowledge sharing, and expertise. I also briefly address the perceived trade‐off between academic rigor and practical utility—a perennial concern in the field. In each case, a review of the literature is performed documenting the progress made by the ES community and other scholarly communities whose findings may be synergistic with ours. Finally, I conclude with a proposal for preserving the momentum started by the ES movement by suggesting a forum for diverse scholarly discourse in systems engineering.