bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application of 3D technology for tooth autotransplantation: A case report
Authors: Kim Keunhee , Choi Hee‐Seung , Pang Nan‐Sim 
Published: February 2018

AbstractThis report presents two cases of tooth autotransplantation using cone‐beam computed tomography (CBCT), the three‐dimensional (3D) simulation dental planning software and a computer‐aided rapid prototyping (CARP) model. Two hopeless teeth of adult patients were replaced as their third molar teeth. Before deciding the autotransplantation, diagnostic CBCT images were acquired and imported to SimPlant software. The SimPlant dental program was used for surgical simulation prior to autotransplantation, which created 3D images of the available donor teeth and recipient site tooth and superimposed the images to display their morphological similarity. Efficient modification of the recipient socket was designed preoperatively. The CARP model of the donor tooth was prepared as a substitute for the donor tooth that would be fit into the new recipient socket during bone preparation. Autotransplantation was favourably performed in 5–6 min. Transplanted teeth healed up without clinical abnormality. The postoperative follow‐up time was up to 6 years.
Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study
Authors: Petousis Stamatios , Prapas Yannis , Margioula‐Siarkou Chrysoula , Ravanos Konstantinos , Milias Stefanos , Mavromatidis George , Kalogiannidis Ioannis , Haitoglou Costas , Athanasiadis Apostolos , Prapas Nikolaos , Rousso David 
Published: February 2018

ProblemΤo assess the endometrial expression of progesterone receptors in various subgroups of infertile women during implantation window.ΜethodsA prospective observational study was performed during March 2013‐February 2017. Infertile women were categorized to those with tubal factor, ovarian failure, endometriosis or unexplained infertility. Endometrial biopsy was obtained on 7th‐8th postovulatory day. Total progesterone receptors’ PR(A + B) and type‐B receptors’ (PR‐B) expression were compared between all categories of infertile and fruitful controls.ResultsThere were overall 30 patients with tubal factor infertility (group 1), 30 with ovarian failure (group 2), 20 with endometriosis (group 3) and 20 with unexplained infertility (group 4). The control group consisted of 30 fertile patients. Patients with unexplained infertility presented the lowest levels of epithelial endometrial expression both regarding PR(A + B) and PR‐B receptors. PgR(A + B) h‐score in luminal epithelial cells was 106.4 ± 14.7 for cases with unexplained infertility vs 219.7 ± 15.8 for controls (P < .001). Similarly, PgR(A + B) h‐score in glandular epithelial cells was 109.7 ± 13.9 vs 220.1 ± 17.2 (P < .001). Relative remarks were made for type‐B progesterone receptors.ConclusionΕndometrial expression of progesterone receptors is impaired in women with unexplained infertility. Therapeutic strategies targeting on improving progesterone receptors’ expression may significantly affect final reproductive outcome.
Is sonographically measured cervical length at 37 weeks of gestation associated with intrapartum cesarean section? A prospective cohort study
Authors: de Vries Bradley , Narayan Rajit , McGeechan Kevin , Santiagu Stanley , Vairavan Ramesh , Burke Minke , Phipps Hala , Hyett Jon 
Published: February 2018

AbstractIntroductionCesarean section rates continue to increase globally. Prediction of intrapartum cesarean section could lead to preventive measures. Our aim was to assess the association between sonographically measured cervical length at 37 weeks of gestation and cesarean section among women planning a vaginal birth. The population was women with a low‐risk pregnancy or with gestational diabetes.Material and methodsThis was a prospective cohort study conducted in a tertiary referral hospital in Sydney, Australia. In all, 212 women with a low‐risk pregnancy or with gestational diabetes were recruited including 158 nulliparous and 54 parous women. Maternal demographic, clinical and ultrasound characteristics were collected at 37 weeks of gestation. Semi‐Bayesian logistic regression and Markov chain Monte Carlo simulation were used to assess the relation between cervical length and cesarean section in labor.ResultsRates of cesarean section were 5% (2/55) for cervical length ≤20 mm, 17% (17/101) for cervical length 20–32 mm, and 27% (13/56) for cervical length >32 mm. These rates were 4, 22 and 33%, respectively, in nulliparous women. In the semi‐Bayesian analysis, the odds ratio for cesarean section was 6.2 (95% confidence interval 2.2–43) for cervical length 20–32 mm and 10 (95% confidence interval 4.8–74) for cervical length >32 mm compared with the lowest quartile of cervical length, after adjusting for maternal age, parity, height, prepregnancy body mass index, gestational diabetes, induction of labor, neonatal sex and birthweight centile.ConclusionsCervical length at 37 weeks of gestation is associated with intrapartum cesarean section.
Extended physical education in children aged 6–15 years was associated with improved academic achievement in boys
Authors: Cöster ME , Fritz J , Karlsson C , Rosengren BE , Karlsson MK 
Published: February 2018

AbstractAimPhysical activity (PA) has been associated with enhanced cognition, brain development and concentration. This study evaluated whether increased physical education (PE) improved academic achievement.MethodsWe recruited 304 children (55% boys) from a Swedish school in Skane County in 1998–2002 when they were six to seven years of age and followed them through all nine mandatory school years. Their PE level was increased from 60 to 200 minutes per week, and their results were compared with 73 885 control children (51% boys) in the county who graduated in the same years and did the standard 60 minutes of PE per week. Their academic achievements were measured as their final grade scores and the proportion of students eligible for upper secondary school.ResultsThe eligibility for further education increased in the intervention boys by 6.8 percentage points and the mean grade score by 12.1 points, while in the control group as a whole, the eligibility rate decreased by 0.7 percentage points and the mean grade score increased by 1.7 points. No changes in eligibility rates or mean grade scores were seen in the intervention girls.ConclusionIncreasing weekly PE over nine years was associated with improved academic achievement in boys.
Initiation and long‐term use of benzodiazepines and Z‐drugs in bipolar disorder
Authors: Wingård Louise , Taipale Heidi , Reutfors Johan , Westerlund Anna , Bodén Robert , Tiihonen Jari , Tanskanen Antti , Andersen Morten 
Published: February 2018

ObjectivesIncreasing evidence points to the harmful effects of long‐term benzodiazepine treatment. Our objective was to study the incidence of, and predictors for, long‐term use of benzodiazepines and Z‐drugs in bipolar disorder.MethodsWe conducted a population‐based cohort study, using data from Swedish national registers. Swedish residents aged 18‐75 years with a recorded diagnosis of bipolar disorder or mania between July 2006 and December 2012, and no history of benzodiazepine/Z‐drug use in the past year, were included. Patients were followed for 1 year with regard to prescription fills of benzodiazepines/Z‐drugs. Initiators were followed for another year during which continuous use for >6 months was defined as “long‐term”. Patient and prescription characteristics were investigated as potential predictors for long‐term use in multivariate logistic regression models.ResultsOut of the 21 883 patients included, 29% started benzodiazepine/Z‐drug treatment, of whom one in five became long‐term users. Patients who were prescribed clonazepam or alprazolam had high odds for subsequent long‐term use (adjusted odds ratios [aORs] 3.78 [95% confidence interval (CI) 2.24‐6.38] and 2.03 [95% CI 1.30‐3.18], respectively), compared to those prescribed diazepam. Polytherapy with benzodiazepines/Z‐drugs also predicted long‐term use (aOR 2.46, 95% CI 1.79‐3.38), as did age ≥60 years (aOR 1.93, 95% CI 1.46‐2.53, compared to age <30 years), and concomitant treatment with psychostimulants (aOR 1.78, 95% CI 1.33‐2.39).ConclusionsThe incidence of subsequent long‐term use among bipolar benzodiazepine initiators is high. Patients on clonazepam, alprazolam or benzodiazepine/Z‐drug polytherapy have the highest risk of becoming long‐term users, suggesting that these treatments should be used restrictively.
A Wild Bootstrap Approach for the Aalen–Johansen Estimator
Authors: Bluhmki Tobias , Schmoor Claudia , Dobler Dennis , Pauly Markus , Finke Juergen , Schumacher Martin , Beyersmann Jan 
Published: February 2018

Summary
We suggest a wild bootstrap resampling technique for nonparametric inference on transition probabilities in a general time-inhomogeneous Markov multistate model. We first approximate the limiting distribution of the Nelson–Aalen estimator by repeatedly generating standard normal wild bootstrap variates, while the data is kept fixed. Next, a transformation using a functional delta method argument is applied. The approach is conceptually easier than direct resampling for the transition probabilities. It is used to investigate a non-standard time-to-event outcome, currently being alive without immunosuppressive treatment, with data from a recent study of prophylactic treatment in allogeneic transplanted leukemia patients. Due to non-monotonic outcome probabilities in time, neither standard survival nor competing risks techniques apply, which highlights the need for the present methodology. Finite sample performance of time-simultaneous confidence bands for the outcome probabilities is assessed in an extensive simulation study motivated by the clinical trial data. Example code is provided in the web-based Supplementary Materials.
Evaluation of factors contributing to the decline in exclusive breastfeeding at 6 months postpartum: The 2011‐2016 National Surveys in Taiwan
Authors: Waits Alexander , Guo Chao‐Yu , Chien Li‐Yin 
Published: February 2018

AbstractBackgroundSince 1992, breastfeeding promotion in Taiwan considerably raised the breastfeeding rates; however, more recent surveillance showed that breastfeeding indicators stagnated or even decreased.MethodsWe analyzed 6 cross‐sectional national surveys of 69 159 postpartum women to examine the breastfeeding trends at 6 months postpartum during 2011‐2016 in Taiwan and the contributing role of maternal and environmental factors. Data were collected through telephone interviews, using structured questionnaires with randomly selected mothers, who gave birth in those years. A multinomial logistic regression was used to analyze the data.ResultsPartial breastfeeding rates at 6 months postpartum increased from 2011 to 2016 (25.4%‐45.1%, crude odds ratio [OR] = 1.14 per year of study); however, the rates of exclusive breastfeeding at 6 months postpartum declined (24.5%‐14.8%, crude OR = 0.91 per year of study). During this period, increases in maternal age and educational level, employment outside the house, and prepregnancy obesity were observed. Despite a growing number of births at certified baby‐friendly hospitals, fewer mothers experienced early skin‐to‐skin contact and rooming‐in in 2016 than in 2011. Adjustment for breastfeeding‐related factors did not appreciably change the odds ratio for year of birth. Prenatal intention to breastfeed was most strongly associated with breastfeeding at 6 months postpartum (OR > 5).ConclusionsMaternal and environmental factors in the study could not explain the decline in exclusive breastfeeding. The decline in exclusive breastfeeding, accompanying the increase in partial breastfeeding, suggests that more support is needed for mothers who intend to breastfeed exclusively.
Poaching and Firm‐Sponsored Training
Authors: Mohrenweiser Jens , Zwick Thomas , Backes‐Gellner Uschi 
Published: February 2018

AbstractA series of seminal papers argues that poaching hampers company‐sponsored general training. Empirically, however, the existence and extent of poaching remain open questions. We provide a novel empirical strategy to identify poaching. We find that only few apprenticeship training firms in Germany are ‘poaching victims’ or ‘poaching raiders’. Victims are more likely to be in a temporary downturn and raiders are more likely to be growing. Victims hardly change their training strategy after poaching and poaching seems be a transitory event. This is an important result for countries that intend to introduce apprenticeship‐type training and need to convince firms to participate in training.
KIAA0247 inhibits growth, migration, invasion of non‐small‐cell lung cancer through regulating the Notch pathway
Authors: Xu Yitong , Ren Hongjiu , Jiang Jun , Wang Qiongzi , Wudu Muli , Zhang Qingfu , Su Hongbo , Wang Chenglong , Jiang Lihong , Qiu Xueshan 
Published: February 2018

Lung cancer remains the leading cause of cancer‐related death worldwide. Previous studies have shown that the novel KIAA0247 gene potentially targeted by the tumor suppressor p53 may inhibit the development of several cancers. However, the exact function of KIAA0247 in non‐small‐cell lung cancer (NSCLC) is unknown. The purpose of the present study was to clarify the role of KIAA0247 in NSCLC. KIAA0247 expression was evaluated in tumors and adjacent normal tissues of 197 NSCLC patients by immunohistochemistry and real‐time PCR and analyzed for association with clinicopathological parameters. Results indicated that KIAA0247 levels positively correlated with cell differentiation (P < .001) and patient survival (P < .0001) and negatively correlated with lymph node metastasis (P < .001) and advanced p‐TNM stage (P < .001). In cultured NSCLC cell lines, KIAA0247 overexpression inhibited cell migration, invasion, and proliferation and downregulated the expression of Jagged1, Notch1 intracellular domain (NICD), Snail, cyclin D1, RhoA, RhoC, and MMP9, while upregulating that of E‐cadherin and p21. The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling. Our results indicate that KIAA0247 inhibits NSCLC progression by reducing the metastatic potential of cancer cells through downregulation of the Notch pathway, which may underlie the association of KIAA0247 expression with favorable clinicopathological characteristics of NSCLC patients. These findings suggest that KIAA0247 is a candidate prognostic biomarker and potential therapeutic target in NSCLC.
Computational studies on horseshoe shape pocket of human orexin receptor type 2 and boat conformation of suvorexant by molecular dynamics simulations
Authors: Bai Qifeng , Pérez‐Sánchez Horacio , Shi Zhuoyu , Li Lanlan , Shi Danfeng , Liu Huanxiang , Yao Xiaojun 
Published: February 2018

The FDA approved drug suvorexant binds to the horseshoe shape pocket of OX2R with the boat conformation. The horseshoe shape pocket plays an important role on the biological activity of OX2R in the cell membrane. To study the binding mechanism between the horseshoe shape pocket of OX2R and boat conformation of suvorexant, the crystal structures of wild type and N324A mutant of OX2R in complex with antagonist suvorexant are chosen to perform molecular dynamics (MD) simulations, QM/MM, and MMGBSA calculations. By comparison with the wild type of OX2R, the results show the 1,2,3‐triazole and p‐toluamide groups of suvorexant are changed in the N324A mutant of OX2R during 200 ns MD simulations. The QM/MM and weak interaction analysis are employed to calculate the non‐covalent bonds interaction between suvorexant and key residues in the wild type and N324A mutant of OX2R. The MMGBSA calculations indicate the entropy energy is an important influence factor for suvorexant affinity in the distorted horseshoe shape pocket of OX2R. Our results not only show the horseshoe shape pocket of OX2R is the necessary conformation for the binding of antagonist suvorexant, but also give the important sites and structural features for antagonist design of OX2R.
Adolescents’ Friendships, Academic Achievement, and Risk Behaviors: Same‐Behavior and Cross‐Behavior Selection and Influence Processes
Authors: Gremmen Mariola C. , Berger Christian , Ryan Allison M. , Steglich Christian E.G. , Veenstra René , Dijkstra Jan K. 
Published: February 2018

This study examined to what extent adolescents’ and their friends’ risk behaviors (i.e., delinquency and alcohol use) hinder or promote their academic achievement (grade point average [GPA]), and vice versa. Longitudinal data were used (N = 1,219 seventh‐ to ninth‐grade adolescents; Mage = 13.69). Results showed that risk behaviors negatively affected adolescents’ GPA, whereas GPA protected against engaging in risk behaviors. Moreover, adolescents tended to select friends who have similar behaviors and friends’ behaviors became more similar over time (same‐behavior selection and influence). Furthermore, although same‐behavior effects seemed to dominate, evidence was found for some cross‐behavior selection effects and a tendency in seventh grade for cross‐behavior influence effects. Concluding, it is important to investigate the interplay between different behaviors with longitudinal social network analysis.
Eosinophil‐derived exosomes contribute to asthma remodelling by activating structural lung cells
Authors: Cañas J. A. , Sastre B. , Rodrigo‐Muñoz J. M. , Fernández‐Nieto M. , Barranco P. , Quirce S. , Sastre J. , del Pozo V. 
Published: February 2018

SummaryBackgroundEosinophils, a central factor in asthma pathogenesis, have the ability to secrete exosomes. However, the precise role played by exosomes in the biological processes leading up to asthma has not been fully defined.ObjectiveWe hypothesized that exosomes released by eosinophils contribute to asthma pathogenesis by activating structural lung cells.MethodsEosinophils from asthmatic patients and healthy volunteers were purified from peripheral blood, and exosomes were isolated from eosinophils of asthmatic and healthy individuals. All experiments were performed with eosinophil‐derived exosomes from healthy and asthmatic subjects. Epithelial damage was evaluated using primary small airway epithelial cell lines through 2 types of apoptosis assays, that is, flow cytometry and TUNEL assay with confocal microscopy. Additionally, the epithelial repair was analysed by performing wound healing assays with epithelial cells. Functional studies such as proliferation and inhibition‐proliferation assays were carried out in primary bronchial smooth muscle cell lines. Also, gene expression analysis of pro‐inflammatory molecules was evaluated by real‐time PCR on epithelial and muscle cells. Lastly, protein expression of epithelial and muscle cell signalling factors was estimated by Western blot.ResultsAsthmatic eosinophil‐derived exosomes induced an increase in epithelial cell apoptosis at 24 hour and 48 hour, impeding wound closure. In addition, muscle cell proliferation was increased at 72 hours after exosome addition and was linked with higher phosphorylation of ERK1/2. We also found higher expression of several genes when both cell types were cultured in the presence of exosomes from asthmatics: CCR3 and VEGFA in muscle cells, and CCL26, TNF and POSTN in epithelial cells. Healthy eosinophil‐derived exosomes did not exert any effect over these cell types.Conclusions and Clinical RelevanceEosinophil‐derived exosomes from asthmatic patients participate actively in the development of the pathological features of asthma via structural lung cells.
Evaluation of an abutment‐level superpower sound processor for bone‐anchored hearing
Authors: Bosman A.J. , Kruyt I.J. , Mylanus E.A.M. , Hol M.K.S. , Snik A.F.M. 
Published: February 2018

ObjectivesPerformance of an abutment‐level superpower sound processor for bone‐anchored hearing, the Ponto 3 SuperPower from Oticon Medical (BCD2), was compared to an earlier model from Oticon Medical (BCD1).DesignA comparative study in which each patient serves as its own control.SettingTertiary clinic.ParticipantsEighteen experienced BCD1 users with profound mixed hearing loss.Main outcome measuresSpeech reception thresholds in noise; APHAB and SSQ questionnaires.ResultsIn a group of 18 patients with severe mixed hearing loss, the performance of a recently introduced bone conduction device (BCD2) is evaluated relative to that of an earlier model (BCD1). Speech reception thresholds for the sentence‐in‐noise test in the speech and noise frontal condition are not significantly different (P > .05) for BCD1 and BCD2. Speech reception thresholds for frontal speech and three identical noise sources are 1.7 dB lower for BCD2 than for BCD1 (P < .05). With the APHAB questionnaire, the score for background noise is significantly lower (P < .01), that is more favourable, for BCD2 than for BCD1 with an effect size of 0.91. The APHAB domain scores for ease‐of‐communication, reverberation and aversiveness of loud sounds are not significantly different for both devices (P > .05). Scores for the speech, spatial and quality of hearing domains of the SSQ questionnaire are significantly higher (P < .01), that is more favourable, for BCD2 than for BCD1 with effect sizes of 1.22, 0.71 and 1.05, respectively. Scores for the SSQ‐factors “speech understanding,” “spatial,” “clarity, separation and identification” and “listening effort and concentration” were all significantly higher (P < .05) for BCD2 than for BCD1, with effect sizes of 1.28, 0.64, 0.98 and 0.78, respectively. On a proprietary questionnaire, 16 patients indicate a preference for BCD2 over BCD1 for conversations in a small group and two patients have no preference for either device. In a large group, one patient prefers BCD1, six patients have no preference, and eleven patients prefer BCD2. When listening to music, all patients prefer BCD2 over BCD1, with a strong preference for BCD2 for seven patients. When asked for an overall preference, all patients prefer BCD2 over BCD1, with nine patients strongly preferring BCD2.ConclusionsThe lower speech reception thresholds in noise with BCD2 relative to BCD1 can be attributed to the “speech omni” directionality mode of BCD2. The combination of an improved directionality for primarily low‐level inputs and a higher maximum force output, relevant for mid‐ and high‐level inputs, results in a clear preference for BCD2 over BCD1.