bluuebunny/crossref_metadata_2025_split huggingface dataset:
Über einen neuartigen kongenitalen Gerinnungsdefekt (Mangel an Stuart-Faktor)
Authors: Bachmann F , Duckert F , Flückiger P , Hitzig W , Koller F 
Published: June 2018

ZusammenfassungBei einem Säugling mit ungewöhnlich schwerer hämorrhagischer Diathese wurde ein Gerinnungsdefekt festgestellt, der folgende Charakteristika aufweist: Quicksche Prothrombinzeit stark verlängert, Gerinnungszeit mit Russel Vipers Venom stark verlängert, Prothrombin-Verbrauchstest pathologisch, Faktor-VII-Bestimmung mit bovinem Seitzplasma (einstufig) 1 bis 3%. Faktor IX (einstufig) 30%, Thromboplastingeneration mit Patientenserum stark pathologisch, wird durch Mischung mit Hämophilie-B-Serum völlig, mit Marcoumarserum (Beginn der Marcoumartherapie) ebenfalls normalisiert. Plasma und Serum des Patienten „Stuart” (Graham) und unseres Patienten zeigten in allen Tests dasselbe Verhalten.
L’Accolement des plaquettes à une surface étrangère
Authors: Bounameaux Y 
Published: June 2018

Résumé1. L’accolement des plaquettes dans le rotator de H. P. Wright dépend de la formation de thrombine agissant en présence de cofacteurs.2. Les plaquettes ne s’accolent à des levures que si celles-ci ont été “opsonisées”. Cette opsonisation ne fait apparemment intervenir aucun des facteurs de coagulation.3. Les plaquettes adhèrent instantanément à certaines surfaces, telles celles de grains de BaSO4 ou de kaolin.4. L’auteur discute l’importance de ces constatations et des conclusions qu’on en peut tirer quant à l’accolement des plaquettes au niveau de l’endothélium lésé.
Über eine neue Familie mit Angiohämophilie A (vaskuläre Hämophilie)
Authors: Klesper Robert , Achenbach Walter 
Published: June 2018

ZusammenfassungDie Kasuistik einer von der echten Hämophilie abzugrenzenden hämorrhagischen Diathese mit verlängerter Blutungszeit und kongenitalem Mangel an Anti-hämophilem Globulin wird um eine Familie erweitert, bei der sich das Leiden über 3 Generationen in dominantem Erbgang verfolgen läßt. Die Krankheit wird als Angiohämophilie” (vaskuläre Hämophilie [16]) bezeichnet und gehört zur Gruppe der hämorrhagischen Diathesen mit hämophilieähnlichem Blutungstyp und verlängerter Blutungszeit bei normaler Thrombozytenzahl. Diese Gruppe der Blutungskrankheiten tritt bei Männern und Frauen auf, wird also nicht wie die Hämophilie rezessiv-geschlechtsgebunden vererbt. Mit Hilfe moderner Gerinnungsteste, welche die Analyse eines Blutthromboplastinmangels gestatten, lassen sich die „Angiohämophilie A” (mit AHG-Mangel) und „B” (mit Faktor-IX-Mangel) von der „Thrombopathie von Willebrand-Jürgens “ (Plättchenfaktor-3-Mangel) und der „Pseudohämophilie ohne nachweisbaren Gerinnungsdefekt” abtrennen. Klinisches Bild, Differentialdiagnose, Prognose und Therapie des Blutungsleidens werden besprochen.
Lack of Antibodies to Clotting Factors in the Blood of Hemophiliacs Refractory to Transfusions)
Authors: Penalver Jorge A , Holburn R. R , Carroll R. T , Tocantins L. M 
Published: June 2018

Summary1. The blood of 11 Hemophilia “A” patients refractory to transfusions has been studied for the presence of precipitins against certain clot-accelerating fractions. The tests were invariably negative. Identical results were observed in 10 Hemophilia “A” patients non-refractory to transfusions, in 2 cases of Hemophilia B, in 5 patients with miscellaneous conditions and in 11 normal individuals.2. When unheated Fraction I of Cohn is used as antigen, false positive results due to formation of fibrin clots were observed with all human sera tested. This may be a source of error in the interpretation of the tests, especially in the blood of refractory Hemophilia “A” patients with an unusually long clotting time and slow prothrombin conversion.3. These observations do not support the hypothesis that the refractory state to blood transfusions observed in some Hemophilia “A” patients is due to the presence of antibodies against certain clot-accelerating fractions of normal plasma.
Über das Vorkommen eines Antiheparinfaktors in Thrombozyten und Geweben
Authors: Deutsch E , Wawersich E , Franke G 
Published: June 2018

ZusammenfassungAuch in wäßrigen Hirnextrakten konnte eine Antiheparinaktivität nachgewiesen werden, die von der Thrombokinase-Aktivität abgetrennt werden kann. Es wird vorgeschlagen, in Analogie zum Thrombozytenfaktor 4 von einer Hirn-faktor-4-Aktivität zu sprechen. Beide zeigen eine weitgehende Übereinstimmung ihrer Eigenschaften bezüglich Thermolabilität, Lagerungsstabilität, Löslichkeit und Fällbarkeit. Die Wirkung der Hirnextrakte bedarf jedoch zu ihrer vollen Entwicklung einer Inkubation, die bei den Thrombozytenextrakten nicht erforderlich ist. Allerdings verschwindet dieser Unterschied nach Alkoholfraktio-nierung der Hirnextrakte.
Untersuchungen über clie Aktivierung von Serum-Proteasen durch Antigen-Antikörper-Reaktionen
Authors: Kaiser E 
Published: June 2018

ZusammenfassungEs wurde an Hand von Versuchen in vivo und in vitro gezeigt, daß Zusätze von Antigen zum Serum sensibilisierter Kaninchen zu einer Aktivierung der Serumprotease führen, wodurch verschiedene ältere Untersuchungen, insbeson dere aber die Befunde von Ungar zumindest teilweise bestätigt wurden. Für die erwähnte Antigenaktivierung der Serumprotease ist das Komplementsystem von ausschlaggebender Bedeutung; komplementfreies oder C’3-freies Serum läßt sich durch Antigenzusatz nicht aktivieren. Die Antigenaktivierung läßt sich durch Heparin aufheben.Die mutmaßliche Bedeutung der Versuche als Modell für das anaphylaktische Geschehen wird diskutiert und an Hand von Versuchen mit dem Arthus-Phäno-men (lokalisierte anaphylaktische Reaktion) erläutert.
Use of Different Tissue Thromboplastins in the Control of Anticoagulant-Therapy
Authors: Verstraete Marc , Clark Patricia A. , Wright Irving S. 
Published: June 2018

SummaryAn analysis of the results of prothrombin time tests with different types of thromboplastins sheds some light on the problem why the administration of coumarin is difficult to standardize in different centers. Our present ideas on the subject, based on experimental data may be summarized as follows.Several factors of the clotting mechanism are influenced by coumarin derivatives. The action of some of these factors is by-passed in the 1-stage prothrombin time test. The decrease of the prothrombin and factor VII levels may be evaluated in the 1-stage prothrombin time determination (Quick-test). The prolongation of the prothrombin times are, however, predominantly due to the decrease of factor VII activity, the prothrombin content remaining around 50 per cent of normal during an adequate anticoagulant therapy. It is unlikely that this degree of depression of prothrombin is of major significance in interfering with the coagulation mechanism in the protection against thromboembolism. It may, however, play a minor role, which has yet to be evaluated quantitatively. An exact evaluation of factor VII is, therefore, important for the guidance of anticoagulant therapy and the method of choice is the one which is most sensitive to changes in factor VII concentration. The 1-stage prothrombin time test with a rabbit lung thromboplastin seems the most suitable method because rabbit brain preparations exhibit a factor VII-like activity that is not present in rabbit lung preparations.
Organization of the ,,Thrombosis Service” in the Netherlands
Authors: Jordan F. L. J 
Published: June 2018

SummaryThe working schedule of the Thrombosis Service at Utrecht, which was founded in 1949, is discussed.In the Netherlands the Red Cross stimulates the organization of thrombosis services in the towns of some importance. At this moment there are about 9 of such services at work, not all of which are organized by the Red Cross. Some statistical results of the Utrecht Service, calculated over 7 years, are presented.It appears that it is indeed possible to lower the mortality in myocardial infarction considerably by the application of long-term treatment.
Management of Hepatic Trauma: An Update
Authors: Dahan Isaac , Ho Vanessa , Kapoor Baljendra , Lang Min 
Published: June 2018

AbstractBeing the largest solid abdominal organ, the liver is the second most commonly injured organ after abdominal trauma. In this review, we discuss the American Association for the Surgery of Trauma's (AAST) liver injury grading system and World Society of Emergency Surgery's triage grading system. Furthermore, we discuss the role of imaging in hepatic trauma, as well as the indications, techniques, and roles of nonoperative and operative management.
Effectiveness of Homeopathic Medicines as Add-on to Institutional Management Protocol for Acute Encephalitis Syndrome in Children: An Open-Label Randomized Placebo-Controlled Trial
Authors: Oberai Praveen , Padmanabhan Maya , Upadhyaya Alok , Singh Supriya , Singh Samarendra , Vikram Deepika , Khan Tariq , Prasad Ramesh , Gupta A. , Singh J. , Manchanda Raj , Varanasi Roja 
Published: June 2018

Background Acute encephalitis syndrome (AES) is endemic to certain parts of India, with limited treatment options. In our initial exploratory comparative observational study of 151 patients with AES, there was significantly reduced mortality with adjunctive homeopathy compared to institutional management protocol (IMP). The present randomized placebo-controlled trial brings more statistical rigor to this research program.
Methods This study was conducted at a pediatric unit from 2013 to 2015. Children aged > 6 months and ≤ 18 years and receiving IMP were randomized to receive adjunctive homeopathy (n = 325) or placebo as control (n = 323). The primary effectiveness analysis was based on Glasgow Outcome Scale (GOS). Morbidity was assessed using the Liverpool Outcome Score for Assessing Children at Follow-up. Analysis was by intention to treat.
Results A total of 612 children were analyzed (Homeopathy [H] = 304; Control [C] = 308). The primary outcome, GOS, differed significantly between H and C groups. There was 14.8% death/neuro-vegetative state in the H group compared to 29.8% in the C group. Relative risk was 0.49 (95% confidence interval [CI]: 0.36 to 0.68), with absolute risk reduction of 15.0% (95% CI: 8.6 to 21.6%). Number needed to treat to prevent one additional death/neuro-vegetative state was 6.6 (95% CI: 4.6 to 11.6). Proportional-odds analysis also revealed a greater effect in the H group: odds ratio, 0.40 (95% CI: 0.27 to 0.60). The most frequently used medicines were Belladonna (n = 116), Stramonium (n = 33), Arsenicum album (n = 25), Sulfur (n = 18), Opium (n = 17), and Nux vomica (n = 10).
Conclusion Adjunctive homeopathic medicines may improve clinical outcomes associated with AES. Further randomized and controlled studies, using double-blinded trial design, are recommended to discover if the current findings may be corroborated.
Age-Related Changes and Reference Values of Bicaudate Ratio and Sagittal Brainstem Diameters on MRI
Authors: Garbade Sven , Boy Nikolas , Heringer Jana , Kölker Stefan , Harting Inga 
Published: June 2018

AbstractCranial magnetic resonance imaging (MRI) plays an important role in the diagnosis of neurometabolic diseases, and, in addition, temporal patterns of signal and volume changes allow insight into the underlying pathogenesis. While assessment of volume changes by visual inspection is subjective, volumetric approaches are often not feasible with rare neurometabolic diseases, where MRIs are often acquired with different scanners and protocols. Linear surrogate parameters of brain volume, for example, the bicaudate ratio, present a robust alternative that can be derived from standard imaging sequences. Due to the continuing postnatal brain and skull development and later brain involution, it is, however, necessary to compare patient values with age age-adapted normal values.In this article, we present age-dependent normal values derived from 993 standard scans of patients with normal MRI findings (age range: 0–80 years; mean = 19.9; median = 12.8 years) for bicaudate ratio as a measure of global supratentorial volume, as well as the maximal anteroposterior diameters of mesencephalon, pons, and medulla oblongata as parameters of brainstem volume. The provided data allow quantitative, objective assessment of brain volume changes instead of the usually performed visual and therefore subjective assessment.
Veränderungen der Papilla nervi optici im Kindesalter
Authors: Tegetmeyer H. 
Published: June 2018

ZusammenfassungDie Papilla nervi optici ist mithilfe der ophthalmoskopischen Untersuchung der visuellen Inspektion zugänglich. Dadurch ist es möglich, bereits im Säuglings- und frühen Kindesalter Papillenveränderungen zu erkennen, die mit angeborenen Fehlbildungen des Gehirns einhergehen können oder durch Tumoren, akute Erkrankungen des Sehnerven oder des Zentralnervensystems verursacht werden. Zur Dokumentation, Quantifizierung und Verlaufsbeobachtung der Papillenveränderungen stehen verschiedene bildgebende Verfahren zur Verfügung. Die Einteilung der Papillenveränderungen in angeborene Anomalien, in Papillenveränderungen mit Papillenprominenz und in atrophische Veränderungen im Rahmen einer Optikusatrophie hat sich für die Differenzialdiagnose möglicher Ursachen bewährt. Daraus lassen sich in Kooperation zwischen Pädiatern und Ophthalmologen gezielt weiterführende diagnostische und therapeutische Maßnahmen ableiten.
Internal endoscopic drainage as first line or second line treatment in case of postsleeve gastrectomy fistulas
Authors: Gonzalez J. , Lorenzo D. , Guilbaud T. , Bège T. , Barthet M. 
Published: June 2018

Abstract
Background and study aims Management of post-sleeve gastrectomy fistulas (PSGF) recently has evolved, resulting in prioritization of internal endoscopic drainage (IED). We report our experience with the technique in a tertiary center.
Patients and methods This was a single-center, retrospective study of 44 patients whose PSGF was managed with IED, comparing two periods: after 2013 (Group 1; n = 22) when IED was used in first line and before 2013 (Group 2; n = 22) when IED was applied in second line. Demographic data, pre-endoscopic management, characteristics of fistulas, therapeutic modalities and outcomes were recorded and compared between the two groups. The primary endpoint was IED efficacy; the secondary endpoint was a comparison of outcomes depending on the timing of IED in the management strategy.
Results The groups were matched in gender (16 female, 16 male), mean age (43 years old), severity of fistula, delay before treatment, and exposure to previous endoscopic or surgical treatments. The overall efficacy rate was 84 % (37/44): 86 % in Group 1 and 82 % in Group 2 (NS). There was one death and one patient who underwent surgery. The median time to healing was 226 ± 750 days (Group 1) vs. 305 ± 300 days (Group 2) (NS), with a median number of endoscopies of 3 ± 6 vs. 4.5 ± 2.4 (NS). There were no differences in number of nasocavity drains and double pigtail stents (DPS), but significantly more metallic stents, complications, and secondary strictures were seen in Group 2.
Conclusion IED for management of PSGF is effective in more than 80 % of cases whenever it is used during the therapeutic strategy. This approach should be favored when possible.
A corpus-based study of the human impersonal pronoun ('n) mens in Afrikaans
Authors: Van Olmen Daniël , Breed Adri , Verhoeven Ben 
Published: June 2018

Abstract
This article compares the grammaticalizing human impersonal pronoun ('n) mens in Afrikaans to fully grammaticalized men and non-grammaticalized een mens in Dutch. It is shown that 'n mens and een mens can still be used lexically, unlike mens and men, and that ('n) mens and een mens are restricted to non-referential indefinite, universal-internal uses while men exhibits the whole range of (non-) referential indefinite ones. Despite the latter’s presence in the earliest Afrikaans data, it is argued not to have influenced the development of ('n) mens. This pronoun and Dutch een mens are also found to have syntactic functions other than subjecthood, unlike men. The contrast is attributed to their different degrees of grammaticalization. Lastly, the Afrikaans ‘man’-pronoun is shown to differ from its Dutch counterparts in relying on the second person singular for suppletion, though forms of ('n) mens are found to occasionally occur instead.
What kind of evaluative states are emotions? The attitudinal theory vs. the perceptual theory of emotions
Authors: Rossi Mauro , Tappolet Christine 
Published: June 2018

AbstractThis paper argues that Deonna and Teroni's attitudinal theory of emotions faces two serious problems. The first is that their master argument fails to establish the central tenet of the theory, namely, that the formal objects of emotions do not feature in the content of emotions. The second is that the attitudinal theory itself is vulnerable to a dilemma. By pointing out these problems, our paper provides indirect support to the main competitor of the attitudinal theory, namely, the perceptual theory of emotions.
Mindfulness mediates the relationship between mental toughness and pain catastrophizing in cyclists
Authors: Jones Martin I. , Parker John K. 
Published: June 2018

AbstractThe purpose of this study was to examine the direction and magnitude of the relationship between mental toughness and pain catastrophizing and to explore whether mindfulness mediated this relationship. The design of the study was cross‐sectional using self‐report data. We recruited 142 recreational cyclists (female = 32) via online cycling forums. We asked participants to complete measures of mental toughness, dispositional mindfulness, and pain catastrophizing. Following the initial screening of data and the identification of non‐normality and outliers, we calculated robust correlations and regressions to examine the size and direction of effects. Results revealed that mindfulness partially mediated a moderate negative relationship between mental toughness and pain catastrophizing. These results are consistent with prior theory regarding positive traits and their negative association with pain catastrophizing. Unique contributions included showing that mental toughness and mindfulness are positively associated and that mindfulness is negatively associated with pain catastrophizing in this sample of cyclists.
Creatine kinase, neuromuscular fatigue, and the contact codes of football: A systematic review and meta‐analysis of pre‐ and post‐match differences
Authors: Hagstrom Amanda D. , Shorter Kathleen A. 
Published: June 2018

AbstractPhysiological or performance tests are routinely utilised to assess athletes’ recovery. At present, the ideal tool to assess recovery remains unknown. Therefore, the aim of this systematic review was to examine the change in creatine kinase (CK) and neuromuscular function as measured via a countermovement jump (CMJ) following a match in the contact codes of football. A comprehensive search of databases was undertaken with RevMan (V 5.3) used for statistical analysis. Our results demonstrated that CK pre‐ versus post‐match (standardised mean difference (SMD) = 0.90, 95% CI = 0.50 to 1.31, p < .0001), CK pre‐ versus 24 h post‐match (SMD = 1.50, 95% CI = 1.12 to 1.88, p < .00001), and CK pre‐ versus 48 h post‐match all increased significantly (SMD = 0.90, 95% CI = 0.50 to 1.31, p < .0001), while CMJ peak power (PP) pre‐ versus post‐match (SMD = −0.59, 95% CI = −1.12 to −0.06, p = .03), and pre‐ versus 24 h post‐match (SMD = −0.80, 95% CI = −1.31 to −0.28, p = .002) decreased significantly. There was a significant relationship between the change in CK and the change in CMJ PP from immediately pre to immediately post (r = −0.924, p = .025), and between CMJ immediately following a match and 24 h CK change (r = −0.983, p = .017). In conclusion, CK levels increase and performance in the CMJ decreases following a match of a contact code of football. The identification of this relationship may allow coaching staff to implement a standalone measure of recovery.
The social policy agendas of populist radical right parties in comparative perspective
Authors: Fenger Menno 
Published: June 2018

AbstractIn many European countries and in the US, populist right-wing parties are gaining ground. The political agenda of these parties is dominated by their reluctant or even out-right hostile position against migration and foreigners and a strong emphasis on nationalist values in combination with an anti-globalisation economic agenda. In most cases, the social agenda of the radical right parties and politicians are more ambiguous and less clearly explicated. These parties rely on working class ‘insiders’ and therefore may be expected to oppose austerity measures, but at that same time have firm opinions about deservingness and conditionality that may sometimes harm the interests of their voters. This article sets out to explore the social policy agenda of radical right parties in six different countries: the US, Sweden, the Netherlands, Belgium, Germany and France. The article uses content analysis of speeches and party manifestos as its main method of data analysis.
Two planetary systems with transiting Earth-sized and super-Earth planets orbiting late-type dwarf stars
Authors: Díez Alonso E , González Hernández J I , Suárez Gómez S L , Aguado D S , González Gutiérrez C , Suárez Mascareño A , Cabrera-Lavers A , González-Nuevo J , Toledo–Padrón B , Gracia J , de Cos Juez F J , Rebolo R 
Published: June 2018

ABSTRACTWe present two new planetary systems found around cool dwarf stars with data from the K2 mission. The first system was found in K2-239 (EPIC 248545986), characterized in this work as M3.0V and observed in the 14th campaign of K2. It consists of three Earth-sized transiting planets with radii of 1.1, 1.0, and 1.1 R⊕, showing a compact configuration with orbital periods of 5.24, 7.78, and 10.1 d, close to 2:3:4 resonances. The second was found in K2-240 (EPIC 249801827), characterized in this work as M0.5V and observed in the 15th campaign. It consists of two transiting super-Earths with radii 2.0 and 1.8 R⊕ and orbital periods of 6.03 and 20.5 d. The equilibrium temperatures of the atmospheres of these planets are estimated to be in the range of 380–600 K and the amplitudes of signals in transmission spectroscopy are estimated at ∼10 ppm.