bluuebunny/crossref_metadata_2025_split huggingface dataset:
To explore the protective effect and mechanism of KLF7 overexpression on retinal ganglion cells after optic nerve crush in mice
Authors: Hua Dihao , Gu Jingsai , Xie Feijia , Xu Yishuang , Li Zongyuan , Zheng Hongmei , Chen Zhen 
Published: November 2024

Purpose To investigate the protective effect and mechanism of Krüppel-like factor 7 (KLF7) on retinal ganglion cells (RGCs) after optic nerve crush (ONC). Methods Ninety 10-week-old C57BL/6J mice were randomly assigned to five groups. The blank control group (group A), IVT (intravitreal injection) of KLF7 (group B), IVT of phosphate-buffered saline after ONC (group C), IVT of KLF7 after ONC (group D), and IVT of green fluorescent protein after ONC (group E). Retinal electroretinography and immunofluorescence staining were performed to observe the function and survival rate of RGCs on days 3 and 7 after ONC. The Western Blot determined the expressions of JNK 1, ERK, P38, NF-κB, IL-1, IL-6, and TNF-α seven days after ONC. Results After ONC, KLF7 gradually increased from day 3 to day 14, with the peak noted a peak on day 7. On day 7 after ONC, the RGC survival rate in Group D was significantly higher than in groups C ( P = 0.028) and E ( P = 0.007). The negative PhNR wave amplitude significantly decreased in groups C ( P = 0.03) and E ( P = 0.04) compared to group D. Moreover, group D also showed significantly higher ERK levels among the groups (all P < 0.01); NF-κB, IL-1, IL-6, and TNF-α expression decreased significantly in group D compared with groups C and E (all P < 0.01). Conclusions Overexpression of KLF7 improved the survival rate and function of RGCs in mice ONC models by activating the ERK pathway and inhibiting relevant inflammatory factors. KLF7 may be a promising protective factor against optic nerve damage.
Intra-Parotid Recurrent Nasopharyngeal Carcinoma Following Intensity-Modulated Radiation Therapy: A Case Report
Authors: Bourial Abderrahim , Nourallah Laraqui Othmane , Abdillahi Mahamoud Chirwa , Elhani Hiba , Elmjabber Reyzane , Taali Loubna , Anajar Said , Essaadi Mustapha , Snoussi Khalid , Dahbi Zineb , Hajjij Amal 
Published: November 2024

Introduction: Intra-parotid metastasis refers to the spread of cancerous cells from a primary tumor to the lymph nodes within the parotid gland. To our best knowledge, we report the first described case in the literature of a patient who received IMRT for nasopharyngeal carcinoma (UCNT) without sparing the parotid gland and still experienced a recurrence. Case presentation: A 57-year-old male patient of north African origin presented with a left parotid mass that had been evolving for 6 months. He was previously diagnosed with and treated for nasopharyngeal carcinoma 2 years prior to admission, with Intensity-Modulated Radiotherapy (IMRT) without sparing the parotid gland, as well as chemotherapy. Medical imaging was suggestive of recurrence of nasopharyngeal carcinoma and metastasis due to the patient’s medical history. The patient benefited from a total parotidectomy; The histopathological analysis of the surgical specimen confirmed the presence of a poorly differentiated carcinoma (UCNT) with nodal metastasis. Conclusion: Intensity-Modulated Radiation Therapy (IMRT) holds great promise as an alternative treatment option. However, it should be reserved for specific cases with minimal lymph node involvement, and always preceded by a thorough clinical and radiological examination.
The gender congruency effect in sentence context depends on gender transparency and L2 proficiency: A self-paced reading study with Polish–German bilinguals
Authors: Długosz Kamil , Olszewska Anna 
Published: November 2024

Aims and objectives: The gender congruency effect, and so the facilitated retrieval of grammatical gender for translation equivalents of the same gender, has been documented in the recognition of isolated words in L2. Our study investigates whether this effect extends to word recognition in sentence context and whether it is modulated by gender transparency and L2 proficiency. Design/methodology/approach: Sixty late unbalanced Polish–German bilinguals completed a self-paced reading task with noun phrases manipulated for lexical gender congruency with L1 (congruent, incongruent) and noun-internal gender transparency in L2 (transparent, non-transparent). L2 proficiency was assessed through the Dialang test. Data and analysis: Reading times on the noun were analysed by means of linear mixed-effects modelling. Findings/conclusion: Results showed a gender congruency effect that was limited to transparent nouns and which was greater at lower L2 proficiency levels. Originality: The study is the first to investigate the gender congruency effect in the recognition of nouns embedded in grammatical sentences. Significance/implications: The study shows that the presence of a contextualising sentence does not eliminate the cross-language effects of grammatical gender. Furthermore, it provides first evidence that individual noun-internal gender cues modulate the gender congruency effect. The findings are discussed in terms of the relationship between gender transparency at the micro-level and the degree of activation of gender values.
Diagnostic Value of Maximal Systolic Acceleration Measurements in the Follow-up of Complex Endovascular Aortic Repair: Illustration of a Concept
Authors: Willems Siem A. , Brouwers Jeroen J. W. M. , Hamming Jaap F. , Hinnen Jan Willem , van der Vorst Joost R. , van Schaik Jan 
Published: November 2024

Purpose: After complex endovascular aortic repair (cEVAR), long-term surveillance is advocated to monitor for potential (stent-related) complications. Although various imaging modalities are used, computed tomography angiography remains the standard in current clinical practice worldwide. However, radiopaque markers can cause metal artifacts and scattering, hampering assessment of patency of side branches. The maximal systolic acceleration (ACCmax) is a relatively new duplex ultrasound (DUS) parameter measured distal to a stenosis, avoiding in-stent assessment and scattering. The aim of this article is to illustrate the potential diagnostic utility of the ACCmax after cEVAR and visceral artery stenting in general. Technique: The ACCmax is measured at the maximal slope of the upstroke during the systolic phase in arterial flow. By manually connecting 2 points, a tangent line is created in which the maximal acceleration is automatically calculated and expressed in m/s2. A higher value reflects better arterial perfusion proximal to its measurement point. One measurement of a visceral artery takes about 5 minutes. Conclusion: ACCmax measurements can be a useful addition during DUS follow-up after cEVAR or visceral artery stenting, possibly decreasing radiation exposure, nephrotoxicity, and health care costs. Clinical Impact Long-term surveillance after complex endovascular aortic repair (cEVAR) is necessary to monitor for potential (stent-related) complications. Although CTA is the most common modality for imaging, metal artifacts and scattering can hamper the assessment of stent patency. The maximal systolic acceleration (ACCmax) is a duplex ultrasound based parameter that reflects arterial perfusion proximal to its measurement point. Due to its noninvasive nature, it can be a useful addition during follow-up after cEVAR or visceral artery stenting, possibly decreasing radiation exposure, nephrotoxicity and health care costs as well.
Bexotegrast in people with idiopathic pulmonary fibrosis (IPF): a plain language summary of publication of the INTEGRIS-IPF study
Authors: Lancaster Lisa , Cottin Vincent , Ramaswamy Murali , Wuyts Wim A. , Jenkins R. Gisli , Scholand Mary Beth , Kreuter Michael , Valenzuela Claudia , Ryerson Christopher J. , Goldin Jonathan , Kim Grace Hyun J. , Jurek Marzena , Decaris Martin , Clark Annie , Turner Scott M. , Barnes Chris N. , Achneck Hardean E. , Cosgrove Gregory P. , Lefebvre Éric A. , Flaherty Kevin R. 
Published: November 2024

What is this summary about? This plain language summary shares results from a clinical study called INTEGRIS-IPF that was published in the American Journal of Respiratory and Critical Care Medicine in 2024. This study looked at a medicine called bexotegrast (beck-so-teh-grast) as a possible treatment for idiopathic pulmonary fibrosis (i-dee-uh-pa-thick pul-muh-ner-ee fie-bro-sis; IPF). Bexotegrast is an investigational medicine, which means that it is being studied and has not yet been approved by the US Food and Drug Administration (FDA), for people with IPF to take as a treatment. IPF is a chronic, progressive lung disease that makes it hard to breathe and gets worse over time. There is no cure for IPF, treatment includes symptom management and consideration for the use of nintedanib or pirfenidone, which may decrease the pace of disease progression. The study compared bexotegrast to a placebo (a treatment that looks identical to the medicine but has no medicinal effect) to look at how well it works and how safe it is in treating people with IPF. Most people in the study also took one of two medicines that are already approved by the FDA for IPF, pirfenidone or nintedanib.
Factors influencing Chinese doctors to use medical large language models
Authors: Qu Shujuan , Liu Lin , Zhou Min , Zhou Chuting , Campy Kathryn S. 
Published: November 2024

Objective The integration of medical large language models (MLLMs) into healthcare has garnered global interest, however, the determinants of their adoption by medical professionals remain underexplored. This study aims to elucidate the factors influencing doctors’ intention to utilize MLLMs, encompassing both psychological determinants and demographic attributes. Methods An extended theoretical model was developed using constructs derived from the Technology Acceptance Model (TAM) and five constructs. A hybrid online and offline survey was conducted from March to December 2023, including 955 Chinese medical practitioners. Structural equation modeling was utilized to test the research hypotheses. Results The measurement model exhibited satisfactory reliability and validity, with fit indices meeting scholarly standards. Perceived ease of use emerged as a significant predictor of both perceived usefulness and satisfaction. Content quality was identified as a substantial influence on perceived satisfaction but did not significantly predict perceived usefulness. Technical support and social influence were found to significantly affect perceived usefulness without directly impacting satisfaction. Perceived usefulness positively influenced both satisfaction and usage behavior, while perceived risk had a negative effect. A significant relationship between perceived satisfaction and usage behavior was established, with gender, age, education, and professional title moderating this relationship. Conclusions The study provides empirical evidence for understanding the adoption of MLLMs by Chinese doctors, offering management implications for future technical research, development, and implementation in the medical field.
The Relationship Between Defensive Pessimism, Goal Orientation, and Self-Esteem Among Nursing Students
Authors: Atta Mohamed Hussein Ramadan , Rushdan Esraa Elsayed , Elzohairy Nadia Waheed 
Published: November 2024

IntroductionAcademic achievement in nursing students is significantly influenced by their self-esteem and goal orientation. Defensive pessimism, a strategy where students set low expectations to prepare for potential failure, helps them stay motivated and focused. While this cognitive strategy can boost effort and performance, its relationship with self-esteem and goal orientation remains underexplored among nursing students, revealing a gap in understanding how these factors interact to influence academic success.ObjectiveAssess the level and relationship between defensive pessimism, goal orientation, and self-esteem among nursing students at the Faculty of Nursing.MethodFour hundred students were included in the research using a stratified sampling method followed by a simple randomization sampling technique to select 100 students from each academic year. Tools: The Defensive Pessimism Questionnaire, the Goal Orientation Scale, and the Self-Esteem Scale were used.Results56.28% of participants had a low level of defensive pessimism, about two-thirds (62.30%) had a low level of goal orientation, and 70.0% of the students had a mild level of self-esteem. In addition, higher levels of defensive pessimism are significantly associated with stronger goal orientation ( r = .291, p < .001) but lower self-esteem ( r = −.246, p < .001). Additionally, self-esteem is significantly positively correlated with mastery-performance approach goals ( r = .335, p < .001; r = .142, p < .001) and significantly negatively correlated with mastery-performance avoidance goals ( r = −.351, p < .001; r = −.041, p < .001).ConclusionThese findings highlight the complex interplay between defensive pessimism, goal orientation, and self-esteem in nursing students. Understanding these relationships is crucial for developing targeted interventions to enhance academic achievement and psychological well-being among nursing students, potentially by fostering adaptive goal-setting strategies and addressing the impacts of defensive pessimism on self-esteem.
Dental Health Adjuncts and Care: Exploring Access Among Asylum Seekers and Refugees in London, United Kingdom
Authors: Hurry K.J. , Longley N. , Cinardo P. , Chowdhury H. , Ward A. , Eisen S. 
Published: November 2024

Aims: This work examines and describes dental health among people seeking asylum and refugees (PSAR) who are evaluated by the Respond service. This includes access to and use of oral health products, access to dental care, and experience of dental pain. Materials and Methods: The Respond service pilot offered holistic health assessments to PSAR in temporary accommodation within North Central London between July 2021 and March 2023. Relevant data were extracted from anonymized health records of individuals seen by Respond. Data were analyzed with SPSS (version 28.0.0.0; IBM) to produce descriptive statistics and regression models. Results: An overall 1,390 PSAR were included; 78.7% were male. The mean ages of adults and children were 31.6 and 6.8 y. Seventy-seven countries of birth were reported, most commonly Iran (23.1%). Over two-thirds (67.1%) of PSAR were not accompanied by family members; only 17.2% had UK family links. The mean travel duration was 769.3 days; migration reasons were multifactorial, including persecution (31.2%) and conflict (20.5%). In addition, 77.3% of PSAR reported having access to a toothbrush; only 50.8% indicated routinely brushing their teeth, with 38.9% having seen a dentist in <36 mo. Dental pain was common (28.8%). Only 45.8% of children (<16 y) had access to a toothbrush, 32.3% were brushing their teeth twice daily, and 9.7% cited dental pain. Logistic regression identified significant predictors of routine toothbrushing, access to dental care, and dental pain. Female PSAR were more likely to routinely brush their teeth (adjusted odds ratio [OR], 3.19; P < 0.001) and access dental care (adjusted OR, 0.57; P < 0.05). PSAR aged 30 to 39 y (adjusted OR, 1.97; P < 0.05) and those with informal travel modes (adjusted OR, 1.82; P < 0.001) were more likely to experience pain. Conclusion: There is variation in the dental experience of PSAR, but a significant proportion are failing to perform routine toothbrushing, are not regularly accessing dental care, and are experiencing dental pain. Knowledge Transfer Statement: The results of this analysis suggest that there is variation in the dental experience of people seeking asylum and refugees, but many are failing to perform routine toothbrushing, are not regularly accessing dental care, and are experiencing dental pain.
Long-term Outcomes After Total Ankle Arthroplasty: A Systematic Review
Authors: Lee Michael S. , Mathson Lucas , Andrews Clark , Wiese Dylan , Fritz Jessica M. , Jimenez Andrew E. , Law Brian 
Published: November 2024

Background: Total ankle arthroplasty has emerged as a treatment to successfully treat ankle arthritis. Recent studies have reported more than 40 000 total ankle arthroplasties (TAAs) being performed between 2009 and 2019 in the United States. Although recent studies have reported favorable patient-reported outcomes at short- and midterm follow-up, there is a paucity of aggregate literature reporting on long-term patient-reported outcomes (PROs) after TAA. The purpose of this review is to report an aggregate of literature on minimum 10-year patient-reported outcomes after TAA. Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) were queried in June 2024. Primary research articles were included if they reported minimum 10-year PROs or satisfaction for patients who underwent primary TAA and were written in English. Survivorship was reported based on implant failure, which was determined uniquely by each study. Results: Eight studies met the inclusion criteria. A total of 595 ankles with a range of average ages from 51 to 73.7 years were included in the study with follow-up ranging from a minimum of 10 years to a minimum of 20 years. Six of the 8 studies reported average follow-up ranging from 11.9 to 15.8 years. Two of the 8 studies reported significant improvement in PROs following surgery. Survivorship at a minimum of 10-year follow-up ranged from 66% to 94.4%. Average time to implant failure ranged from 4.6 to 13.8 years. Conclusion: Patients undergoing primary TAA were reported to have generally improved PROs at minimum 10- year follow-up. However, they demonstrated variable rates of survivorship ranging from 66% to 94.4%. Of those experiencing implant failure, average time to failure ranged from 4.6 to 13.8 years. Survivorship should be interpreted with caution because of varying definitions between studies. Further studies should seek to standardize the definition of survivorship and reporting of PROs to allow for effective analysis of heterogeneity.
Is Screening for GERD Necessary in All Asymptomatic Lung Transplant Candidates?
Authors: Balinski Aaron , Gessessew Hayalneh , El Halabi Maan , Malamood Mark 
Published: November 2024

Background: Gastroesophageal reflux disease (GERD) is a known contributor to allograft dysfunction after lung transplantation. Evaluation for GERD has been advocated for all lung transplant candidates. The aim of this study is to evaluate the outcomes of GERD testing in lung transplant patients without GERD symptoms and determine if a subset can skip/defer these tests. Methods: A retrospective chart review was conducted on lung transplant candidates who had pre- transplant GI evaluation at our institution between 2019 and 2022. Adult patients were included if they reported no GERD symptoms and completed GERD screening with Multichannel intraluminal impedance-pH testing. Demographics and results of prior testing were collected for included patients. Results were analyzed using STATA. Results: 176 patients met inclusion criteria. 88 (50%) tested positive for GERD and 88 (50%) tested negative. 68/88 (77.3%) were positive by pH alone. Only 20/176 (11%) had elevated reflux episodes and were recommended to undergo anti-reflux procedures. There were no statistically significant differences in evaluated variables differentiating GERD+ versus GERD- patients. Conclusion: Lung transplant candidates without symptoms concerning for GERD tested positive for GERD 50% of the time with no reliable pre-test characteristics to stratify patients. The large majority of positive results were from high acid exposure time alone without elevated reflux episodes—a low risk phenotype for allograft dysfunction. Only 11% had increased reflux episodes and thus were recommended for anti-reflux procedures. Thus, deferring GERD screening in asymptomatic low-risk candidates until post-transplant is unlikely to impact clinical management while benefiting patients and health systems.
Community Health Agents Dismantling Gender Norms in a Machismo Society
Authors: Allen Elizabeth M. , Van Skiba Michael J. , Frisancho Ariel , Llanten Claudia , Izarra Cecilia 
Published: November 2024

Background Community health agents (CHAs) play a crucial role in healthcare delivery and can also impact societal gender norms. This study aims to understand CHAs’ perceptions of gender roles and norms to identify long-term strategies for women’s empowerment. Methods We conducted 90-min focus group discussions (FGDs) among CHAs in Peru. FGDs illuminated women’s perceptions of gender roles and how to empower women in communities. Results In total, 53 CHAs participated across six FGDs. CHAs noted that women face significant barriers, are treated disrespectfully, and relegated to domestic roles. Ideal gender norms were described as having access to education, increasing voice, inclusion in decision-making, and independence. Changing gender norms requires that men, women, families, and communities support women’s progress in society. Conclusions CHAs are in a unique and powerful position to drive social change. Understanding CHAs perceptions can help develop effective strategies for women’s empowerment.