bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 is a Novel Post-Transcriptional Regulator of Ewing Sarcoma Malignancy
Authors: Mancarella Caterina , Pasello Michela , Ventura Selena , Grilli Andrea , Calzolari Linda , Toracchio Lisa , Lollini Pier-Luigi , Donati Davide Maria , Picci Piero , Ferrari Stefano , Scotlandi Katia 
Published: April 2018

Abstract
Purpose: Large-scale sequencing studies have indicated that besides genomic alterations, the posttranscriptional regulation of gene expression or epigenetic mechanisms largely influences the clinical behavior of Ewing sarcoma. We investigated the significance of the RNA-binding protein IGF2BP3 in the regulation of Ewing sarcoma aggressiveness.
Experimental Design: Explorative study was performed in 14 patients with localized Ewing sarcoma using RNA sequencing. Next, 128 patients with localized Ewing sarcoma were divided into two cohorts. In the training set, 29 Ewing sarcoma samples were analyzed using Affymetrix GeneChip arrays. In the validation set, 99 Ewing sarcoma samples were examined using qRT-PCR. Patient-derived cell lines and experimental models were used for functional studies.
Results:Univariate and multivariate analyses indicated IGF2BP3 as a potent indicator of poor prognosis. Furthermore, ABCF1 mRNA was identified as a novel partner of IGF2BP3. Functional studies indicated IGF2BP3 as an oncogenic driver and ABCF1 mRNA as a sponge that by binding IGF2BP3, partly repressed its functions. The combined evaluation of IGF2BP3 and ABCF1 could identify different patient outcomes—high IGF2BP3 and low ABCF1 levels indicated poor survival (25%), whereas low IGF2BP3 and high ABCF1 levels indicated favorable survival (85.5%). The bromodomain and extraterminal domain inhibitor (BETi) JQ1 decreased IGF2BP3 expression, modified the expression of its validated targets and inhibited the capability of Ewing sarcoma cells to grow under anchorage-independent conditions.
Conclusions: The combined assessment of IGF2BP3 and ABCF1 predicts recurrence in Ewing sarcoma patients. Thus, for patients with high expression of IGF2BP3 and poor probability of survival, the use of BETis should be clinically evaluated. Clin Cancer Res; 24(15); 3704–16. ©2018 AACR.
Targeting the Proteasome-Associated Deubiquitinating Enzyme USP14 Impairs Melanoma Cell Survival and Overcomes Resistance to MAPK-Targeting Therapies
Authors: Didier Robin , Mallavialle Aude , Ben Jouira Rania , Domdom Marie Angela , Tichet Mélanie , Auberger Patrick , Luciano Frédéric , Ohanna Mickael , Tartare-Deckert Sophie , Deckert Marcel 
Published: April 2018

Abstract
Advanced cutaneous melanoma is one of the most challenging cancers to treat because of its high plasticity, metastatic potential, and resistance to treatment. New targeted therapies and immunotherapies have shown remarkable clinical efficacy. However, such treatments are limited to a subset of patients and relapses often occur, warranting validation of novel targeted therapies. Posttranslational modification of proteins by ubiquitin coordinates essential cellular functions, including ubiquitin-proteasome system (UPS) function and protein homeostasis. Deubiquitinating enzymes (DUB) have been associated to multiple diseases, including cancer. However, their exact involvement in melanoma development and therapeutic resistance remains poorly understood. Using a DUB trap assay to label cellular active DUBs, we have observed an increased activity of the proteasome-associated DUB, USP14 (Ubiquitin-specific peptidase 14) in melanoma cells compared with melanocytes. Our survey of public gene expression databases indicates that high expression of USP14 correlates with melanoma progression and with a poorer survival rate in metastatic melanoma patients. Knockdown or pharmacologic inhibition of USP14 dramatically impairs viability of melanoma cells irrespective of the mutational status of BRAF, NRAS, or TP53 and their transcriptional cell state, and overcomes resistance to MAPK-targeting therapies both in vitro and in human melanoma xenografted mice. At the molecular level, we find that inhibition of USP14 rapidly triggers accumulation of poly-ubiquitinated proteins and chaperones, mitochondrial dysfunction, ER stress, and a ROS production leading to a caspase-independent cell death. Our results provide a rationale for targeting the proteasome-associated DUB USP14 to treat and combat melanomas. Mol Cancer Ther; 17(7); 1416–29. ©2018 AACR.
Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine
Authors: Velez Juan Carlos Q. , Obadan Ndidiamaka O. , Kaushal Amit , Alzubaidi Mohammed , Bhasin Bhavna , Sachdev Sachin H. , Karakala Nithin , Arthur John M. , Nesbit Ross M. , Phadke Gautam M. 
Published: April 2018

<b><i>Background:</i></b> Vancomycin-associated (VA) acute kidney injury (AKI) is being increasingly recognized. A distinct pattern of rapid rise in serum creatinine (sCr) during VA-AKI has occasionally been observed. However, such scenarios remain underreported. <b><i>Methods:</i></b> We conducted an online survey at the American Society of Nephrology Communities forum and reviewed publications of VA-AKI via PubMed or Google searching for cases of precipitous AKI (those with rise in sCr ≥1.5 mg/dL/day) attributable to vancomycin. <b><i>Results:</i></b> We identified 12 original cases compiled from 6 different hospitals and 4 published cases (<i>n</i> = 16; 38% women, age 43.5 ± 16 years, weight 108 ± 23 kg, body mass index 35 ± 7 kg/m<sup>2</sup>) of precipitous AKI observed shortly after large cumulative doses of VA (8.8 ± 5 g). The median steepest 24-h rise in sCr was 2.6 mg/dL (range 1.5–3.5 mg/dL) and the slope of the initial 48-h sCr rise was greater than that of a control AKI (non-VA, <i>n</i> = 48) group (2.03 ± 0.1 vs. 0.62 ± 0.0 mg/dL/day; <i>p</i> &#x3c; 0.0001). The steep rise in sCr in the VA-AKI was not accompanied by anuria. Overt rhabdomyolysis was absent in all cases. Further, in 3 precipitous VA-AKI cases, simultaneous serum cystatin C values did not rise precipitously, suggesting that the reductions in glomerular filtration rate were overestimated by the sCr increase. <b><i>Conclusions:</i></b> VA-AKI can manifest with a precipitous rise in sCr shortly after a high cumulative dose of vancomycin. True toxic tubular injury overrepresented by the sCr rise is postulated.
CMOS Temperature Sensor with Programmable Temperature Range for Biomedical Applications
Authors: Setiabudi Agung , Tamura Hiroki , Tanno Koichi 
Published: April 2018

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p class="p1"><span class="s1">A CMOS temperature sensor circuit with programmable temperature range is proposed for biomedical applications. The proposed circuit consists of temperature sensor core circuit and programmable temperature range digital interface circuit. Both circuits are able to be operated at 1.0 V. The proposed temperature sensor circuit is operated in weak inversion region of MOSFETs. The proposed digital interface circuit converts current into time using Current-to-Time Converter (ITC) and converts time to digital data using counter. Temperature range can be programmed by adjusting pulse width of the trigger and clock frequency of counter. The proposed circuit was simulated using HSPICE with 1P, 5M, 3-wells, 0.18-μm CMOS process (BSIM3v3.2, LEVEL53). From the simulation of proposed circuit, temperature range is programmed to be 0 °C to 100 °C, it is obtained that resolution of the proposed circuit is 0.392 °C with -0.89/+0.29 °C inaccuracy and the total power consumption is 22.3 μW in 25 °C.<span class="Apple-converted-space"> </span></span></p></div></div></div>
Apresentação do dossiê – Cosmopolitropicália: diplomacia animista em São Paulo
Authors: Skafish Peter 
Published: April 2018

Em meados do outono passado em São Paulo, mais de 200 estudantes e pesquisadores desafiaram o retrocesso político e econômico de uma forma particularmente audaciosa: eles se deixaram conduzir por uma famosa bruxa em uma dança ritual e canto invocatório realizados em espiral, com o intuito de regenerar a terra em que a cidade foi construída. Starhawk, uma americana ecofeminista, ativista antiglobalização e wicca, foi convidada ao lado do líder indígena Ailton Krenak e de antropólogos estrangeiros e brasileiros para a universidade de São Paulo para a sexta conferência bianual da ReACT (Reunião de Antropologia da Ciência e da Tecnologia). O objetivo de todos era tratar do tema da conferência, o entreviver – um neologismo que se refere ao problema apontado por grupos indígenas latino-americanos sobre como podem (e se podem) os modernos cosmopolitanos e os seres não humanos coexistir de forma bem-sucedida dentro e através de seus respectivos e com frequência bastante divergentes meios político-ecológicos.
Relationship Between Emergency Medical Services Response Time and Bystander Intervention in Patients With Out‐of‐Hospital Cardiac Arrest
Authors: Goto Yoshikazu , Funada Akira , Goto Yumiko 
Published: April 2018

Background

The response time of emergency medical services (
EMS
) is an important determinant of survival after out‐of‐hospital cardiac arrest. We sought to identify upper limits of
EMS
response times and bystander interventions associated with neurologically intact survival.

Methods and Results

We analyzed the records of 553 426 patients with out‐of‐hospital cardiac arrest in a Japanese registry between 2010 and 2014. The primary study end point was 1‐month neurologically intact survival (Cerebral Performance Category scale 1 or 2). Increased
EMS
response time was associated with significantly decreased adjusted odds of 1‐month neurologically intact survival (adjusted odds ratio [
aOR
] for each 1‐minute increase, 0.89; 95% confidence interval [
CI
], 0.89–0.90), although this relationship was modified by bystander interventions. The bystander interventions and the ranges of
EMS
response times that were associated with increased adjusted 1‐month neurologically intact survival were as follows: bystander defibrillation, from ≤2 minutes (
aOR
, 3.10 [95%
CI
, 1.25–7.31]) to 13 minutes (
aOR
, 5.55 [95%
CI
, 2.66–11.2]); bystander conventional cardiopulmonary resuscitation, from 3 minutes (
aOR
1.48 [95%
CI
, 1.02–2.12]) to 11 minutes (
aOR
2.41 [95%
CI
, 1.61–3.56]); and bystander chest‐compression‐only cardiopulmonary resuscitation, from ≤2 minutes (
aOR
1.57 [95%
CI
, 1.01–2.25]) to 11 minutes (
aOR
1.92 [95%
CI
, 1.45–2.56]). However, the increase in neurologically intact survival of those receiving bystander interventions became statistically insignificant compared with no bystander interventions when the
EMS
response time was outside these ranges.

Conclusions

The upper limits of the
EMS
response times associated with improved 1‐month neurologically intact survival were 13 minutes when bystanders provided defibrillation (typically with cardiopulmonary resuscitation) and 11 minutes when bystanders provided cardiopulmonary resuscitation without defibrillation.
Field Observations and Modeling of Surfzone Sensible Heat Flux
Authors: MacMahan Jamie , Thornton Ed , Koscinski Jessica , Wang Qing 
Published: April 2018

AbstractSurfzone sensible heat flux (HS,SZ) obtained through direct eddy-covariance estimates was measured at four different sandy beach sites along Monterey Bay, California. The HS,SZ source region is estimated from a footprint probability distribution function (pdf) model and is only considered when at least 70% of the footprint pdf occupies the surfzone. The measured HS,SZ is 2 times the modeled interfacial sensible heat (HS,int) using COARE3.5. A formulation for estimating sensible heat flux from spray droplets (HS,spray) generated during depth-limited wave breaking is developed. The sea-spray generation function for droplet radii ranging over 0.1 < ro < 1000 μm is based on self-similar spectra of spray droplets measured from the surfzone forced by the average depth-limited breaking wave dissipation across the surfzone. However, it is shown that the size of the spume droplets that contribute to HS,spray is limited owing to the relatively short residence time in air as the droplets fall to the sea surface during wave breaking. The addition of the surfzone-modeled HS,spray to the COARE3.5 HS,int gives values similar to the observed surfzone HS,SZ, highlighting the importance of depth-limited wave-breaking processes to sensible heat flux. Measured HS,SZ values are an order of magnitude larger than simultaneous open ocean observations.
Assessing Hurricane Rainfall Mechanisms Using a Physics-Based Model: Hurricanes Isabel (2003) and Irene (2011)
Authors: Lu Ping , Lin Ning , Emanuel Kerry , Chavas Daniel , Smith James 
Published: April 2018

Abstract
We examine a recently developed physics-based tropical cyclone rainfall (TCR) model and apply it to assess the mechanisms that dominate the magnitude and spatial distribution of TC rainfall, with Hurricanes Isabel (2003) and Irene (2011) as study cases. We evaluate the TCR model using Weather and Research Forecasting (WRF) Model simulations. TCR-generated rainfall fields for the two storms compare well with WRF estimates in terms of both azimuthal mean and spatial distributions. When coupled with a hydrologic model, TCR generates flood peaks over the Delaware River basin for Irene as accurately as WRF. TCR accounts for four major rainfall mechanisms: surface frictional convergence, vortex stretching, interaction of the storm with topography, and interaction of the storm with large-scale baroclinity. We show that these rainfall mechanisms affected the rainfall pattern differently for Isabel and Irene. Frictional convergence is the dominant factor, while other mechanisms are also significant. The frictional convergence depends on the boundary layer formulation, which is relatively simple in TCR and may require calibration of boundary layer parameters. Furthermore, we find that the TC rainfall distribution is strongly dependent on the temporal and spatial variation of the TC wind field, mediated by the physical mechanisms represented by TCR. When coupled with various analytical wind models, TCR generally captures the rainfall distribution, with the Holland wind model performing the best. Given its high computational efficiency, TCR can be coupled with an analytical wind model, a hydrological model, and a TC climatology model to generate large numbers of synthetic events to assess the risk associated with TC rainfall and inland flooding.
Development and Validation of a Long-Term, Global, Terrestrial Sensible Heat Flux Dataset
Authors: Siemann Amanda L. , Chaney Nathaniel , Wood Eric F. 
Published: April 2018

AbstractSensible heat flux is a turbulent flux driving interactions between the Earth’s surface and the atmosphere, propelling local and regional climate. While turbulent fluxes are measured in situ, global scales require estimates at larger spatial scales, which can be made using remotely sensed satellite data. This study uses a first-order approximation to calculate the unconstrained hourly, terrestrial, 0.5°-resolution sensible heat flux using a land surface temperature consistent with the High Resolution Infrared Radiation Sounder (HIRS) retrievals, six reanalysis-based air temperature products, and a dataset of Zilitinkevich empirical constant Czil values. This sensible heat flux dataset is constrained using the daily Bowen ratio and available energy, to produce nine constrained, daily products. All resulting global, terrestrial averages are within the uncertainty range of ±6.3 W m−2 from the 38.8 W m−2 global annual average previously reported in the literature. The product constrained with the net radiation using the Moderate Resolution Infrared Spectroradiometer (MODIS) albedo and air temperature from the National Centers for Environmental Protection (NCEP) Climate Forecast System Reanalysis (CFSR) performs closest to the FLUXNET ground observations in the monthly analysis. These sensible heat flux estimates should be used for benchmarking global climate models at monthly or annual scales, and improvements should be made to the accuracy of input variables, particularly the temperature gradient, Czil estimates, and the roughness length.
Using Multitrait-Multimethod (MTMM) Techniques to Examine the Convergent and Discriminant Validity of Social Disorder
Authors: Yang Sue-Ming , Hinkle Joshua C. , Wyckoff Laura A. 
Published: April 2018

Objectives: Disorder has been measured by various data sources; however, little attention has been given to comparing the construct validity of different measures obtained through various methods in capturing social disorder and related phenomena. Methods: The multitrait-multimethod approach was used to triangulate the consistency between social disorder, prostitution and drug activity across resident surveys, systematic social observations, and police calls for service data. Results: Prostitution and drug activity showed convergent validity, while there was little evidence that social disorder was consistently measured across the three methods. None of the three social problem measures showed high discriminant validity. Drug activity seems to have highest trait-specific discriminant validity across measures, and prostitution is the most identifiable measure across data sources. Social disorder was found to have low discriminant validity. However, the agreement between databases varies across the type of social problems. Conclusions: Social disorder appears to the most difficult concept to define and measure consistently. The lack of correspondence across data sources cautions against the use of a single source of information in studying disorder. Future studies should explore the factors that shape perceptions of disorder and how to best measure disorder to test the broken windows thesis and related concepts.
Are Financial Incentives for Lifestyle Behavior Change Informed or Inspired by Behavioral Economics? A Mapping Review
Authors: McGill Bronwyn , O’Hara Blythe J. , Bauman Adrian , Grunseit Anne C. , Phongsavan Philayrath 
Published: April 2018

Objective: To identify the behavioral economics (BE) conceptual underpinnings of lifestyle financial incentive (FI) interventions. Data Source: A mapping review of peer-reviewed literature was conducted by searching electronic databases. Study Inclusion and Exclusion Criteria: Inclusion criteria were real-world FI interventions explicitly mentioning BE, targeting individuals, or populations with lifestyle-related behavioral outcomes. Exclusion criteria were hypothetical studies, health professional focus, clinically oriented interventions. Data Extraction: Study characteristics were tabulated according to purpose, categorization of BE concepts and FI types, design, outcome measures, study quality, and findings. Data Synthesis and Analysis: Financial incentives were categorized according to type and payment structure. Behavioral economics concepts explicitly used in the intervention design were grouped based on common patterns of thinking. The interplay between FI types, BE concepts, and outcome was assessed. Results: Seventeen studies were identified from 1452 unique records. Analysis showed 76.5% (n = 13) of studies explicitly incorporated BE concepts. Six studies provided clear theoretical justification for the inclusion of BE. No pattern in the type of FI and BE concepts used was apparent. Conclusions: Not all FI interventions claiming BE inclusion did so. For interventions that explicitly included BE, the degree to which this was portrayed and woven into the design varied. This review identified BE concepts common to FI interventions, a first step in providing emergent and pragmatic information to public health and health promotion program planners.
Availability and Use of Workplace Supports for Health Promotion Among Employees of Small and Large Businesses
Authors: Dale Ann Marie , Enke Chris , Buckner-Petty Skye , Hipp James Aaron , Marx Christine , Strickland Jaime , Evanoff Bradley 
Published: April 2018

Purpose: To explore the availability and utilization of workplace health supports by employees of small and large-sized employers. Design: Cross-sectional, telephone-based interviews collected on 16 workplace health supports for physical activity and diet. Setting: Participants selected by random-digit-dialing from 4 metropolitan areas of Missouri employees from 2012 to 2013. Participants: Two thousand fifteen working adults. Methods: We explored the availability and use of supports by employer size (<100 employees vs ≥100 employees), accounting for industry and personal factors. Analysis: We examined distributions and Poisson regression models of availability for supports by employer size and by industry and use of supports by employer size and personal factors. Results: One-fifth of the 1796 employees were employed by small-sized employers. Large employers offered more supports than small (mean: 6 vs 3), but a higher proportion of employees of small-sized employers used supports when available (59% vs 47%). The differences in offered supports between industries were not due to size alone. In regard to the determinants of participation, the personal factors of gender, age, weight, and income were associated with participation in 10 of the supports. Employer size was also associated with participation in 10 supports. No associations were found between personal factors or workplace size and participation for 3 supports. Conclusion: A higher proportion of employees working for smaller businesses use available supports than employees of larger businesses. Supports offered by employers should target the needs and interests of the workforce, particularly for the higher risk low-income employees.
Factors affecting conscience-based nursing practices: A qualitative study
Authors: Jasemi Madineh , Aazami Sanaz , Hemmati maslak pak Masumeh , Habibzadeh Hosein , Esmaeili Zabihi Roghayeh 
Published: April 2018

Background: Conscience is a guiding factor in nursing practice for delivering the ultimate care. In order to expand the concept of conscience-based care, factors affecting conscience in nursing practice need to be identified. Objectives: The current study assessed nurses’ experiences to explore factors affecting conscience in nursing practice. Research design: This qualitative content analysis study employed purposive sampling to reach 14 nurses working at educational hospitals in Tabriz and Urmia, Iran. Data were analyzed using inductive and conventional analysis. Ethical considerations: This research was approved by the Ethics Committee of Urmia University of Medical Science. Voluntary participation, anonymity, and confidentiality were considered. Finding: Two themes emerged from our analysis for enhancing conscience in nursing practices, including environment of professional performance and personal factors. Discussion: The two important factors for enhancing conscience in nursing practice are environment and personal factors. Conclusion: It is necessary to emphasize on religious beliefs, professional commitment, and communication skills in educational training structure. Also, establishing appropriate management systems will help nurses to provide moral care.