bluuebunny/crossref_metadata_2025_split huggingface dataset:
Derlin-3 Manipulates the Endoplasmic Reticulum Stress and IgG4 Secretion of Plasma Cells in Lung Adenocarcinoma
Authors: Xu Yuan , Lin Lanlan , Chen Luyang , Lin Guofu , Chen Xiaohui , Yang Jiansheng , Chen Shaohua , Lin Ronghang , Yang Dongyong , He Fei , Qian Danwen , Zeng Yiming 
Published: November 2024

Abstract

Derlin-3 has been implicated as an essential element in the degradation of misfolded lumenal glycoproteins induced by endoplasmic reticulum (ER) stress. However, its potential biomechanisms in the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) remains to be elucidated. In the present study, we found that Derlin-3 was predominantly elevated in LUAD tissues, and could predict worse prognosis of LUAD patients. ScRNA-seq analysis indicated that Derlin-3 was mainly enriched in B lymphocytes in the TME, especially in plasma cells. Moreover, Derlin-3 may be involved in ER stress and IgG4 secretion in plasma cells by targeting p38/PRDM1 pathway. While the aberrant IgG4 production may be an essential driver of the polarization of macrophages towards the M2 phenotype. Additionally, downregulation of Derlin-3 could inhibit plasma cells infiltration and M2 macrophage polarization in vivo. Our results indicated that Derlin-3 could shape TME via ER stress to harness immune function, which might serve as a promising immunotherapeutic target in LUAD.
Delayed gastric emptying in neurocritical care patients
Authors: Sun Xiaoman , Ma Xiaojun , Zhang Liping 
Published: November 2024

Abstract

This study presents a detailed case of a 36-year-old male neurocritical patient who developed superior mesenteric artery (SMA) syndrome following severe traumatic brain injury. We believe that our study makes a significant contribution to the literature because it highlights the clinical challenges in diagnosing and managing SMA syndrome in neurocritical patients, a condition that is often underdiagnosed due to its atypical presentation. Additionally, neurocritical patients usually cannot express their symptoms, which may lead to unrecognized cases that could progress to complete obstruction and become life-threatening.
Comparative Analysis of Quality of Life in Solid Organ Transplant Recipients: The Influence of Skin Cancer
Authors: Aristizabal Miguel A. , Christiansen John , Makhtin Maya , White Launia J. , Heckman Michael G. , Barbosa Naiara S. , Degesys Catherine A. , Tolaymat Leila 
Published: November 2024

Abstract

Background
Dermatological health-related quality of life (HRQoL) among solid organ transplant recipients (SOTRs) may be adversely affected by various factors, including skin cancer. However, there has been limited assessment of dermatological HRQoL in SOTRs. This study aimed to evaluate the impact of skin cancer on quality of life (QoL) in SOTRs and to compare HRQoL measures between SOTRs with and without skin cancer.
Methods
This cross-sectional study was conducted at the Mayo Clinic Florida from June 2023 to March 2024. Adult patients who underwent solid organ transplantation between June 1995 and December 2023 were assessed using the Dermatology Life Quality Index (DLQI) and Skindex-29 questionnaires. For SOTRs with keratinocyte carcinoma (KC), the Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) questionnaire was also administered.
Results
A total of 150 adult SOTRs were included, with 82 having developed post-transplant skin cancer, including melanoma and keratinocyte carcinomas (KC). SOTRs with skin cancer were older at first transplant (Median: 61.8 vs. 57.3 years, P = 0.0073) and had a higher proportion of males (76.8% vs. 55.9%, P = 0.0086). Fitzpatrick skin type III-VI was less prevalent (8.5% vs. 38.2%, P < 0.0001). The frequency of SCC and BCC was 92.7% and 41.5%, respectively. DLQI scores were higher in SOTRs with skin cancer, however, the difference was not statistically significant (P ≥ 0.065). SOTRs with skin cancer had higher total Skindex-29 scores (P = 0.012) and “emotion” subscale scores (P = 0.0049), indicating a negative impact on QoL. BaSQoL scores showed a moderate negative effect on QoL, with a higher number of KCs correlating with lower QoL (P < 0.05). Female gender had higher DLQI total score (P = 0.0042) and BaSQoL diagnosis and treatment (P = 0.031).
Conclusions:
SOTRs with skin cancer exhibited lower overall QoL, with a greater number of skin cancers linked to more pronounced negative impacts on QoL across all assessment instruments. Female gender was also associated with lower QoL scores. Recognizing the potential for reduced QoL in SOTRs is essential for developing tailored management strategies to support this population.
Aneurysmal Subarachnoid Hemorrhage Risk Assessment Model Identifies Patients for Safe Early Discharge at Day 15 – The SAFE-SaHScore
Authors: Kennison Eric E , Murray Nick M , Collingridge Dave S , Knox Daniel , Fontaine Gabriel V 
Published: November 2024

Abstract

Background Patients with aneurysmal subarachnoid hemorrhage (aSAH) are often hospitalized for 21 days after aneurysm rupture due to the risk of complications. However, some never experience complications and are unlikely to benefit from a prolonged hospitalization.Objective The aim of this study is to derive a risk assessment model (RAM) using data from the first 14 days of hospitalization to identify low-risk patients for early discharge, at day 15 or after.Methods Patients > 18 years old with an acute aSAH at a Comprehensive Stroke Center from 2017–2024 were included. Baseline demographics, aSAH grading scales, and in-hospital complications requiring intervention were characterized. Complications included: vasospasm, delayed cerebral ischemia (DCI), cerebral salt wasting (CSW), cerebral edema, seizures, arrhythmias, respiratory failure, and hydrocephalus. Binary logistic regression with leave-one-out cross validation (LOOCV) was used to identify an optimal RAM.Results Of 165 patients, the mean Hunt Hess Score (HHS) was 2.5 (SD 1.2), modified Fisher Score (mFS) was 3.1 (SD 1), endovascular therapy was used for aneurysm securement in 73%, and 54.5% experienced complications during days 15–21. In bivariate analyses, days 0–14 variables associated with days 15 + complications were: HHS, mFS, middle cerebral artery (MCA) aneurysm, clinical or radiologic vasospasm, endovascular therapies, intraventricular hemorrhage, hydrocephalus, external ventricular drain (EVD), mechanical ventilation, vasopressors, hypertonic solutions, antiseizure medications, milrinone, and fludrocortisone (all p < 0.05). LOOCV regression for a best fit RAM included 6-variables: Sum - of vasopressors, Artery - MCA aneurysm, Fludrocortisone, EVD, Scale - modified Fisher Score and Hunt and Hess Score [SAFE-SaH], and had an AUC = 0.90 (0.85–0.95), sensitivity = 0.94, specificity = 0.69, PPV = 79%, and NPV = 91% for predicting complications on day 15+.Conclusions This is the first ever RAM to incorporate clinical data from the first 14 days of hospitalization to identify aSAH patients at low risk for complications after day 14. With 94% sensitivity, the RAM classifies patients who will not have complications and may assist in earlier disposition on day 15 or after.
Elevated Estimated Pulse Wave Velocity and the Risk of Type 2 Diabetes in Non-Obese Young Adults: A Longitudinal Cohort Study
Authors: Zhang Chunxia , Chen Li , Liu Ri 
Published: November 2024

Abstract

Background
Arterial stiffness, measured by estimated pulse wave velocity (ePWV), is associated with a higher risk of cardiovascular diseases and type 2 diabetes mellitus (T2DM) in older and obese individuals. However, the role of arterial stiffness as an early predictor of T2DM in non-obese, young adults remains underexplored. Identifying alternative predictors like arterial stiffness is crucial for detecting diabetes onset in non-obese and younger populations who may not exhibit traditional risk factors such as high Body Mass Index (BMI).This study investigates the association between elevated ePWV and the risk of T2DM in non-obese young adults, who are often overlooked in diabetes prevention efforts.
Methods
The study included 9,543 non-obese participants (BMI < 25 kg/m², age < 50 years) from the NAGALA cohort in the Gifu area. ePWV was calculated, and participants were followed for the development of diabetes. Cox proportional hazard models assessed the association between ePWV and T2DM risk, adjusting for age, sex, BMI, alcohol consumption, exercise, smoking status, and metabolic biomarkers. Subgroup analyses examined the association's consistency across sex, age, smoking, and alcohol consumption.
Results
During a median follow-up period of 6.3 years, 110 participants (1.2%) developed T2DM.In the unadjusted model, elevated ePWV was significantly linked to a higher risk of T2DM (HR 1.85, 95% CI 1.53–2.23, p < 0.001).The association remained significant after adjusting for confounders (HR 1.36, 95% CI 1.05–1.75, p = 0.018).Subgroup analysis showed no significant interactions across sex, age, alcohol consumption, or smoking status.
Conclusions
Elevated ePWV independently correlates with a higher risk of T2DM in non-obese young adults. ePWV may serve as a valuable tool for early diabetes risk identification in this population.
Mild cognitive impairment is associated with effect of uremic toxin on gray matter structural changes in end-stage kidney disease
Authors: Yuan Huijie , Luo Zhaoyao , Yang Jing , Ma Shaohui , Li Peng , Wang Xinyi , Su Hang , He Ronghua , Mu Junya , Zhang Yuchen 
Published: November 2024

Abstract

To investigate the grey matter volume (GMV) changes and uremic toxin in end-stage kidney disease (ESKD) patients with mild cognitive impairment (MCI) (ESKD-MCI) and further examine the classification and diagnostic efficacy of these features for ESKD-MCI patients. A total of 65 patients with ESKD, including 34 ESKD-MCI and 31 with non-cognitive impairment (ESKD-NCI), and 55 health controls (HCs) were enrolled. All participants underwent brain structural magnetic resonance imaging (MRI) scanning and Montreal cognitive assessment (MoCA) test. Clinical characteristics and GMV differences among these three groups were analyzed. In addition, mediation analysis was performed to determine the mediating effect of GMV changes on the association between clinical risk factors and MCI. Finally, support vector machine were employed to examine the classification and diagnostic efficacy of GMV changes and clinical features for MCI. Both patient groups exhibited widespread structural brain injury compared with the HCs. Moreover, compared with ESKD-NCI, ESKD-MCI patients demonstrated reduced GMV specifically in the left middle temporal gyrus and inferior temporal gyrus. Notably, these GMV changes completely mediates the effect of serum phosphorus levels on MCI. Furthermore, imaging features rather than serum phosphorus levels had good classification and diagnostic efficacy for ESKD-MCI. Our findings underscore the significance of the left temporal gyrus as a pivotal brain region in ESKD-MCI patients, fully mediating the link between uremic toxin and MCI. GMV alterations presents a promising avenue for effectively detecting MCI in individuals with ESKD.
Environmental salinity differentially impacts branchial and hepatic carbohydrate metabolism in tilapia
Authors: Chang Ryan J. A. , Celino-Brady Fritzie T. , Breves Jason P. , Seale Andre P. 
Published: November 2024

Abstract

In response to changes in environmental salinity, euryhaline fishes mobilize energy to support the active transport of ions across osmoregulatory epithelia. Cortisol operates as both a glucocorticoid and mineralocorticoid in fishes and supports salinity acclimation, in part, by modulating the energetic pathways that regulate glucose availability. Glycogen synthase (GS) and glycogen phosphorylase (GP) are key controllers of carbohydrate metabolism given their promotion of glycogenesis and glycogenolysis, respectively. Nonetheless, the coordinated responses of GS, GP, and glucose transporters (GLUTs) in the liver and gill to changes in salinity remain unresolved. In the current study, we initially subjected Mozambique tilapia (Oreochromis mossambicus) to unidirectional transfers, from either fresh water (FW) to seawater (SW) or from SW to FW. Then, we transferred FW- and SW-acclimated tilapia to a tidal regime (TR) where salinity alternated between FW and SW every 6 h. Whether fish were transferred from SW to FW in a unidirectional fashion or to a TR, glucose increased following transfer to FW or during the FW-phase of the TR (TF) relative to the SW-phase (TS). Conversely, hepatic glycogen was higher in SW- or TS-fish versus fish in TF. In FW and TF, branchial expression of the gill-specific isoform of GP (gpg) was downregulated, whereas gs was upregulated. Branchial gpg was upregulated in fish unidirectionally transferred from FW to SW or sampled during TS. Hepatic gp and gs expression increased following transfer from SW to FW. Moreover, while branchial glut1 was downregulated following transfer from FW to SW, glut1 was transiently upregulated in the liver. In both liver and gill, glut1 was higher in fish in TF versus TS. Gill filament explants incubated with cortisol exhibited diminished glut1 expression irrespective of media osmolality. Our collective data indicate that environmental salinity differentially modulates hepatic and branchial glycogen metabolism in euryhaline tilapia.
Exploring biomarkers in Fabry disease: GDF15, LGALS3, and oxidative stress
Authors: KUŞ Berna , terzi Menderes Yusuf , Turgut Faruk Hilmi , Arpacı Abdullah 
Published: November 2024

Abstract

Fabry disease (FD) is an X-linked rare lysosomal storage disorder. The absence of alpha-galactosidase-A enzyme activity leads to the accumulation of globotriaosylceramide in various cells, causing multi-organ damage. The aim of our study was to explore various parameters that may be clinically valuable in the pathogenesis including growth differentiation factor 15 (GDF15), leucine-rich alpha-2-glycoprotein-1 (LRG1), galectin-3 (LGALS3), and oxidative stress parameters in patients with FD. We included 25 Fabry patients along with 28 healthy volunteers. Serum levels of LGALS3, GDF15, and LRG1 were measured using enzyme-linked immunosorbent assay, while total antioxidant status (TAS) and total oxidant status (TOS) parameters were measured using a colorimetric method, and oxidative stress index (OSI) values were calculated. Additionally, routine biochemical parameters (glucose, ALT, AST, BUN, creatinine, sodium, potassium, calcium, phosphorus, uric acid) of both patient and control groups were measured. Receiver operating characteristic (ROC) analysis was employed to evaluate the discriminatory ability of certain parameters in Fabry patients. Biochemical parameters were similar between the groups. In the patient group, GDF15, LGALS3, and TAS values were significantly higher compared to the control group. The area under the curve (AUC) values obtained from the ROC analysis for LGALS3, GDF15, sodium, TAS, TOS, and OSI parameters were 0.7821, 0.6957, 0.8879, 0.6714, 0.5016, and 0.5699, respectively. Parameters LGALS3, GDF15, and TAS are considered to possess discriminatory characteristics for FD.
Postoperative adjuvant immunotherapy versus standard of care in resectable locally advanced head and neck squamous cell carcinoma with intermediate- and high-risk factors: a real-world retrospective study
Authors: Shi Xiaoqiong , Zhu Minhui , He Jianqiao , Gao Yingna , Ma Yi , Li Haopu , Yu Guoning , Zhao Lin , Zheng Hongliang , Zhang Caiyun 
Published: November 2024

Abstract

Improving the prognosis of patients with LA-HNSCC who have intermediate- and high-risk factors has long been a priority for head and neck surgeons. Immunotherapy, particularly programmed cell death protein 1 (PD-1) inhibitor, has shown promise. However, there are currently no reports on the use of PD-1 inhibitors for postoperative adjuvant treatment of these patients. This retrospective study included 59 postoperative intermediate- and high-risk patients with LA-HNSCC. These patients were divided into two groups: a standard therapy group, consisting of patients who received only postoperative risk-adapted adjuvant (chemo)radiation (n = 34), and an adjuvant immunotherapy group, consisting of patients who received adjuvant immunotherapy as a follow-up maintenance regimen after the standard of care (n = 25). Progression-free survival (PFS) and overall survival (OS) by the Response Evaluation Criteria for Solid Tumors was the main outcome. The 2-year PFS and OS rates in the adjuvant immunotherapy group were 80.0% and 95.0%, respectively, compared to 62.1% (χ2 = 2.465, P = 0.116) and 79.3% (χ2 = 2.434, P = 0.119) in the standard therapy group. Stratified analysis showed that the 2-year PFS rate for patients in the adjuvant immunotherapy group with programmed death ligand 1 (PD-L1) combined positive score (CPS) ≥ 20 significantly improved compared to the standard therapy group (92.9% vs. 62.1%, χ2 = 4.644, P = 0.031). No serious immune-related adverse events were detected in the adjuvant immunotherapy group. Our study suggests administering PD-1 inhibitor as adjuvant therapy after standard of care shows a trend towards improving 2-year PFS in postoperative intermediate- and high-risk patients with LA-HNSCC. This trend is more pronounced in patients with a CPS of 20 or higher. Future clinical trials are needed to verify these results.
Spatial Prioritization for the Implementation of Payments for Ecosystem Services Programs in the Feijão River Basin, São Carlos-Sp, Brazil
Authors: Cunha Tiago Pedro Silva da , de Sousa Matheus Natan Ferreira Alves , Ramalho José Arthur do Nascimento , Pereira Caio Víctor Macêdo , Costa Carlos Wilmer 
Published: November 2024

Abstract

Essential for maintaining life on Earth, ecosystem services also have economic value as scarce goods subject to human appropriation. However, the value of these services may be lost because landholders generally receive no compensation for the benefits their land provides for others. Payments for ecosystem services (PES) are an alternative solution to this problem, whereby the beneficiaries of ecosystem services reward the providers of these services with a view to producing positive externalities. Based on this concept, the study aimed to develop and apply a methodological approach to identify priority areas for the implementation of PES programs in the Feijão River Basin (FRB), São Carlos, São Paulo state (SP), Brazil. To that end, a soil erosion vulnerability map was developed by reinterpreting information available in thematic maps characterizing the physical, biotic, and anthropic environments of the Feijão River Basin, using the methodology of Crepani et al. (2001) in a Geographic Information Systems (GIS) environment. Additionally, economic valuation of the productive activities carried out on each property listed in the Rural Environmental Registry (CAR) was performed based on land cover mapping and the Net Present Value (NPV) and Equivalent Annual Value (EAV) methods. Finally, spatial prioritization of the watershed for PES program implementation was achieved by cross-referencing information on environmental vulnerability and economic value. This resulted in a priority area of ​​1,382.97 ha, with an EAV of $97,887.54, corresponding to the intersection between areas most vulnerable to soil erosion and pasture areas, which have the lowest opportunity cost.
Strong impact of orally administered BCR4 defensin on aphid survival, embryo development and symbiotic cells in three Acyrthosiphon pisum parthenogenetic lines
Authors: Terrasson Hugo , Gaget Karen , Lapetoule Garance , Rahioui Isabelle , Renoz François , Benhamou Sylvain , Jouve Chrystele , Sivignon Catherine , Duport Gabrielle , Aucagne Vincent , Simon Jean-Christophe , Ribeiro-Lopes Mélanie , Calevro Federica , Silva Pedro Da 
Published: November 2024

Abstract

Aphids are major crop pests capable of colonizing the main plants grown for human consumption. They have specialized cells, the bacteriocytes, which house the obligatory symbionts Buchnera aphidicola that provide them with essential nutrients missing from their diet. Bacteriocyte-specific cysteine-rich peptides (BCRs) are encoded by a defensin gene family exclusively present in aphids and specifically expressed in bacteriocyte. One BCR family member, BCR4, has been shown to have insecticidal properties against the pea aphid, Acyrthosiphon pisum(Hemiptera: Aphididae). In the present study, we exposed the pea aphid to different doses of BCR4 and examined the impact on aphid survival, mass, anatomy, fecundity, as well as on bacterial symbiosis. As different pea aphid lines with various symbiotic status may be differently affected by stress, we investigated the effect of BCR4 ingestion on three different A. pisum lines: LL01 and YR2-amp, that are mono-infected with B. aphidicola, and YR2-Ri, that is genetically identical to YR2-amp but also contains the extracellular facultative symbionts Regiella insecticola. Our results show a strong dose-response effect of BCR4 on LL01 survival and a more moderate effect on both YR2 lines, while an impact on the mass was observed in the three lines. Histological analyses revealed severe embryonic developmental defects due to the treatment. Finally, BCR4 treatment reduced symbiont quantity, with B. aphidicola being more affected than R. insecticola. This study supports the idea that BCR4 could act as a key regulator of aphid symbiosis and development, and highlights its potential as a candidate bioinsecticide for pest control.
Leveraging Large Language Models to Build a Cutting-Edge French Word Sense Disambiguation Corpus
Authors: Mehdoui Mouheb , Fraisse Amel , Zrigui Mounir 
Published: November 2024

Abstract

With the increasing amount of data circulating over the Web, there is a growing need to develop and deploy tools aimed at unraveling semantic nuances within text or sentences. The challenges in extracting precise meanings arise from the complexity of natural language, while words usually have multiple interpretations depending on the context. The challenge of precisely interpreting words within a given context is what the task of Word Sense Disambiguation meets. It is a very old domain within the area of Natural Language Processing aimed at determining a word’s meaning that it is going to carry in a particular context, hence increasing the correctness of applications processing the language. Numerous linguistic resources are accessible online, including WordNet [1], thesauri[2], and dictionaries, enabling exploration of diverse contextual meanings. However, several limitations persist. These include the scarcity of resources for certain languages, a limited number of examples within corpora, and the challenge of accurately detecting the topic or context covered by text, which significantly impacts word sense disambiguation.This paper will discuss the different approaches to WSD and review corpora available for this task. We will contrast these approaches, highlighting the limitations, which will allow us to build a corpus in French, targeted for WSD.