bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Re)conceptualising Good Care in Hospital Settings From the Perspectives of Older Persons: A Concept Analysis Using Pragmatic Utility
Authors: Millar Nick Anthony , Hoben Matthias , Dahlke Sherry , Hunter Kathleen F. 
Published: November 2024

ABSTRACTPurposeTo understand good care from the perspective of hospitalised older persons.BackgroundOlder persons are the largest group of hospital users, and numbers will increase in the next decades. Hospital organisations are attempting to transform traditional care models to meet the specialised needs of hospitalised older persons. To achieve this, healthcare providers including nurses and administrators need to understand the perspectives of hospitalised older persons on what constitutes good care. This knowledge is critical to nursing to ensure that care aligns with the perceived needs of hospitalised older persons. However, good care from the viewpoints of hospitalised older persons remains ambiguous and poorly delineated in the literature.MethodsWe conducted a concept analysis using the pragmatic utility method. To identify peer‐reviewed articles, we searched CINAHL, MedLine, PsycINFO, Scopus and Embase databases for related literature using the keywords and related terms to ‘good care’, ‘hospital or acute care’ and ‘older persons’.ResultsTwenty‐two peer‐reviewed articles out of 2144 search results were included. The heterogeneity of older persons' perspectives and limitations in the literature on good care led to a tentative understanding. Good care, a partially mature concept, is the provision of person‐centred, culturally sensitive, holistic and integrated care that fosters autonomy, control and participation, resulting in a sense of belonging, smooth transitions, optimal management of clinical conditions, satisfaction in care and informed older persons and family caregivers.ConclusionOlder persons are a heterogeneous group with diverse perceptions of good care. Instead of seeking a common understanding of good care, efforts should be focused on identifying individual preferences, values and goals of hospitalised older persons.Implications for PracticeThe components of good care are important for many hospitalised older persons and can serve as a starting point for improvements in practice settings. However, this understanding is tentative and may overlook critical aspects of care at an individual level. Hospital organisations, healthcare providers and nurses should be cognizant of this limitation and cultivate adaptability for an individualised approach to care.
The unmet need for certification of vision impairment for people accessing a national primary care‐based low vision rehabilitation service
Authors: John Rebecca , Williams Gwyn , Morgan Tim , George Michael R. , Reynolds Rhianon , Acton Jennifer H. 
Published: November 2024

AbstractBackgroundThe certificate of vision impairment has an important role in enabling access to support for people with vision impairment (VI) and the provision of epidemiological data regarding sight loss. However, the rates of certification may not accurately reflect the number of people living with certifiable VI.MethodsObservational data from a national primary care low vision rehabilitation service between 1 April 2021 and 31 March 2022 were analysed. Descriptive statistics were used to describe the certification status of patients with certifiable VI. For patients with age‐related macular degeneration (AMD) and best‐corrected visual acuity of 6/60 or worse, logistic regression was undertaken to assess the effects of patient characteristics on certification status.ResultsFor patients with AMD and certifiable levels of visual acuity, 41.00% (n = 426) were not certified. The reported certification was 60.09% (n = 256) and 58.24% (n = 357) for neovascular AMD and atrophic AMD, respectively. Existing patients of the service were 3.87 times more likely to be certified than new patients (OR 3.87, 95% CI 2.7–5.4). Increasing age (OR 1.02, 95% CI 1.004–1.038) and decreasing visual acuity (OR 0.62, 95% CI 0.50–0.78) were associated with an increased likelihood of certification.ConclusionA significant number of patients live with certifiable vision impairment but do not access certification. Policy changes in Wales now enable patients with bilateral atrophic AMD to access certification within the primary care setting. Given the unmet need, consideration should be given to primary care certification in the rest of the UK, and in Wales, the potential to expand the scope of conditions.
CRISPR/Cas knockout of the NADPH oxidase gene OsRbohB reduces ROS overaccumulation and enhances heat stress tolerance in rice
Authors: Liu Xiaolong , Ji Ping , Liao Jingpeng , Duan Ximiao , Luo Zhiyang , Yu Xin , Jiang Chang‐Jie , Xu Chen , Yang Hongtao , Peng Bo , Jiang Kai 
Published: November 2024

SummaryHeat stress (HS) has become a major factor limiting crop yields worldwide. HS inhibits plant growth by ROS accumulation, and NADPH oxidases (Rbohs) are major ROS producers in plants. Here, we show that CRISPR/Cas knockout of the OsRbohB (OsRbohB‐KO) significantly increased rice tolerance to HS imposed at various different growth stages. We produced OsRbohB‐KO and OsRbohB‐overexpression (OsRbohB‐OE) lines in a japonica cultivar, Nipponbare. Compared with nontransgenic wild‐type (WT) plants, the OsRbohB‐KO lines showed a significant increase in chlorophyll contents (5.2%–58.0%), plant growth (48.2%–65.6%) and grain yield (8.9%–20.5%), while reducing HS‐induced ROS accumulation in seeds (21.3%–33.0%), seedlings (13.0%–30.4%), anthers (13.1%–20.3%) and grains (9.7%–22.1%), under HS conditions. Analysis of yield components revealed that the increased yield of OsRbohB‐KO plants was due to increased starch synthetase activity, spikelets per panicle (2.0%–9.3%), filled spikelets (4.8%–15.5%), percentage of filled spikelets (2.4%–6.8%) and 1000‐grain weight (2.9%–7.4%) under HS conditions during the reproductive stage. Grain milling and appearance quality, and starch content were also significantly increased in OsRbohB‐KO plants under HS conditions during the mature stage. Furthermore, OsRbohB‐KO significantly upregulated the expression levels of heat shock‐related genes, OsHSP23.7, OsHSP17.7, OsHSF7 and OsHsfA2a, in rice seedlings and grains under long‐term HS conditions. Conversely, OsRbohB‐OE resulted in phenotypes that were opposite to OsRbohB‐KO in most cases. Our results suggest that suppression of OsRbohB provides an effective approach for alleviating heat damage and improving grain yield and quality of rice under long‐term HS conditions.
Xylem and Phloem in Petioles Are Coordinated With Leaf Gas Exchange in Oaks With Contrasting Anatomical Strategies Depending on Leaf Habit
Authors: Martín‐Sánchez Rubén , Sancho‐Knapik Domingo , Ferrio Juan Pedro , Alonso‐Forn David , Losada Juan Manuel , Peguero‐Pina José Javier , Mencuccini Maurizio , Gil‐Pelegrín Eustaquio 
Published: November 2024

ABSTRACTAs the single link between leaves and the rest of the plant, petioles must develop conductive tissues according to the water influx and sugar outflow of the leaf lamina. A scaling relationship between leaf area and anatomical traits of xylem and phloem is expected to improve the efficiency of these tissues. However, the different constraints compromising the functionality of both tissues (e.g., risk of cavitation) must not be disregarded. Additionally, deciduous and evergreen plants may have different strategies to produce and package their petiole conduits to cope with environmental restrictions. We explored in 33 oak species the relationships between petiole anatomical traits, leaf area, stomatal conductance, and photosynthesis rate. Results showed allometric scaling between anatomical structure of xylem and phloem with leaf area. We also found correlations between photosynthesis rate, stomatal conductance, and anatomical traits in the petiole. The main novelty is how oaks present a different strategy depending on the leaf habit. Deciduous species tend to increase their diameters to achieve greater leaf‐specific conductivity. By contrast, evergreen oaks develop larger xylem conductive areas for a given leaf area than deciduous ones. This trade‐off between safety‐efficiency in petioles has never been attributed to the leaf habit of the species.
Homocysteine S‐Methyltransferase 3 Positively Regulates Cadmium Tolerance in Maize
Authors: Lin Kaina , Xu Kewen , Chen Yiqing , Lu Yifan , Zhou Meixue , Cao Fangbin 
Published: November 2024

ABSTRACTThe increasing contamination of agricultural soils with cadmium (Cd) poses a significant threat to human health and global food security. Plants initiate a series of mechanisms to reduce Cd toxicity. However, the response of maize to Cd toxicity remains poorly understood. In this study, we identified that ZmHMT3, which encodes a homocysteine S‐methyltransferases family protein, acted as a regulator of Cd tolerance in maize. Subcellular localization and in situ PCR exhibited that ZmHMT3 was localized in the cytoplasm and predominantly expressed in the phloem. Overexpression of ZmHMT3 enhanced Cd tolerance and reduced Cd concentration in both shoots and roots. In contrast, ZmHMT3 mutants attenuated Cd tolerance but did not change shoot Cd concentration. Heterologous overexpression of ZmHMT3 in rice enhanced Cd tolerance and reduced grain Cd concentration. Transcriptome analysis revealed that ZmHMT3 upregulated the expression of stress‐responsive genes, especially glutathione S‐transferases (GSTs) and transcription factors, including MYBs, NACs and WRKYs, and modulates the expression of different ATP‐binding cassette (ABC) transporters, thereby enhancing Cd tolerance. Collectively, these findings highlight the pivotal role of ZmHMT3 in Cd tolerance and as a candidate gene for improving Cd tolerance in elite maize varieties.
Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan
Authors: Huang Mao‐Hsuan , Cheng Chih‐Ming , Hsu Ju‐Wei , Bai Ya‐Mei , Su Tung‐Ping , Li Cheng‐Ta , Tsai Shih‐Jen , Chan Yee‐Lam E , Chen Mu‐Hong 
Published: November 2024

AimBipolar disorder (BD) and major depression have been associated with an increased risk of developing Parkinson's disease (PD); however, few studies have directly compared the risk of PD development between patients with BD and major depression while considering relevant risk factors and psychotropic medications.MethodsUsing the Taiwan National Health Insurance Research Database, 21,186 patients with BD, 21,188 patients with major depression, and 42,374 controls were enrolled between 2001 and 2009, and followed until the end of 2011. Individuals who developed PD during the follow‐up period were identified. Cox regression models were used to analyze the hazard ratio (HR) of developing PD, adjusting for demographic factors, comorbidities, and psychotropic medication usage.ResultsBoth patients with BD [HR 8.63, 95% confidence interval (CI) 6.35–11.72] and those with major depression (HR 5.68, 95% CI 4.15–7.78) had an elevated risk of subsequent PD compared to the controls. Patients with BD were associated with a 51% increased risk of subsequent PD compared with patients with major depression. Long‐term treatment with antiepileptic mood stabilizers was associated with increased PD risk among patients with late‐onset BD and high Charlson comorbidity index scores. Lithium was not associated with an increased PD risk.ConclusionsThe study highlights an elevated PD risk in patients with BD and major depression compared to the controls, with BD patients at highest risk. Further research is needed to elucidate the complex interplay between psychotropic medications and neurodegenerative processes in BD, aiming to optimize therapeutic strategies and improve patient outcomes.
Comparison and evaluation of feature matching methods for multisource planetary remote sensing imagery
Authors: Ye Zhen , Zhou Yingying , Xu Yusheng , Huang Rong , Wan Genyi , Qian Jia , Xie Huan , Tong Xiaohua 
Published: November 2024

AbstractFeature‐based image matching is a critical technique in photogrammetry and computer vision. Recently, various advanced image matching methods have been proposed. The effectiveness of these methods is significantly challenged in the case of multisource planetary images which often have to deal with unique surface morphologies, observed by different sensors and under different illumination and viewing conditions. This study investigates and evaluates the performances of 13 feature detectors across diverse images from Moon and Mars, captured by different sensor systems under different radiometric and geometric conditions. Also, the performances of 12 feature descriptors are assessed. A ranking for combinations of detectors and descriptors is determined. The results reveal that phase congruency‐based algorithms achieve favourable performance in both feature detection and description. On the other hand methods based on deep learning may obtain better results if training data of high quality were available. Finally, we summarise the capabilities and limitations of multisource remote sensing image matching methods and provide discussions and prospects for future research.
T. Muris Infection Dynamics of a Fresh, Wild Isolate: Is the Established E Isolate Still Relevant?
Authors: Mair Iris , Bennett Alexander R. , Forman Ruth , Othman Abdulrazzag A. , Logunova Larisa , Smith Hannah , Lowe Ann E. , Bradley Janette E. , Thornton David J. , Else Kathryn J. 
Published: October 2024

ABSTRACTFor decades, parasitic worms such as Trichuris muris have been maintained in laboratory animals, providing insights into host–parasite interactions and host immune responses. The most used T. muris isolate is the E isolate, established in the laboratory in 1954. However, one concern with these model systems is the potential for laboratory‐induced selection and therefore changes in host–parasite interactions. To address these concerns, we compare the E isolate with a recently isolated T. muris isolate (M isolate), established from wild house mice (Mus musculus domesticus, Isle of May, UK), in their capacity to infect laboratory mice. High dose infection of C57BL/6 mice revealed that significantly more parasites of the M isolate survived to the adult stage compared to the E isolate. Worm persistence was associated with heightened TNF‐α and IL‐10 secretion upon parasite‐specific re‐stimulation, and higher serum IgG1 and IgG2c levels, concomitant with an increase in T‐bet+ and ICOS+ CD4+ T effector‐memory cells. Differences in host response to the isolates were not as pronounced during low dose infection. Our study highlights the need for regular evaluation of lab‐maintained parasite isolates against freshly isolated parasites to understand whether the established lab strains remain relevant model systems for our understanding of parasitic infections.
The concealed information test with a continuously moving stimulus
Authors: Wolsink Lianne N. , Meijer Ewout H. , Smulders Fren T. Y. , Orthey Robin 
Published: November 2024

AbstractThe Concealed Information Test (CIT) aims to extract concealed crime‐related knowledge using physiological measures. In the present study, we propose a new variant of the CIT that contains a continuously moving stimulus. A total of 81 participants were either informed or not about the specific location of an upcoming terrorist attack. The CIT consisted of a map with a superimposed moving dot, combined with measurements of respiration and electrodermal activity. The results revealed both respiratory suppression and an increase in skin conductance when the moving dot passed the target location only in informed participants. These findings showed that this new variant of the CIT can differentiate between groups of informed and uninformed individuals and an exploratory analysis revealed it can help narrow down a search area.
Supplementing the Beltsville Extender With Mitoquinol Improves the Quality and Fertility Potential of the Rooster's Cooled Sperm
Authors: Nateghi Reihaneh , Masoudi Reza , Asadzadeh Nader 
Published: November 2024

ABSTRACTSupplementing freeze diluents with certain antioxidants can maintain the quality of chilled sperm. The present study was an attempt to investigate the effect of Beltsville extender supplementation with the mitochondrial‐targeted antioxidant ‘Mitoquinol’ on the quality parameters and fertility potential of rooster sperm during the cooling process. Semen samples were diluted in Beltsville extender, divided into five groups, and supplemented with 0, 1, 10, 100 and 1000 nM Mitoquinol. Samples were stored at 5°C for up to 50 h and then assayed for sperm motility, viability, mitochondrial function, membrane integrity and malondialdehyde concentration after 0, 25 and 50 h of cooling. To assess reproductive performance, artificial insemination was performed using sperm cooled for 25 h. The results showed no differences between groups at the beginning time. Extender supplementation with 10 and 100 nM Mitoquinol resulted in an improvement in total motility, progressive motility, membrane integrity, mitochondrial function and viability (p ≤ 0.05), as well as a lower malondialdehyde concentration (p ≤ 0.05) in comparison to the other groups during 25 and 50 h storage. Fertility rates were higher when roosters were inseminated with semen samples supplemented with 10 and 100 nM Mitoquinol, compared to the control group. Therefore, supplementing Beltsville extender with Mitoquinol (10 and 100 nM) effective in improving the quality and fertility potential of cooled rooster sperm.
Fast and simple fluorometric measurement of phloem loading exposes auxin‐dependent regulation of Arabidopsis sucrose transporter AtSUC2
Authors: Ren Yunjuan , Zhang Ziyu , Zhanakhmetova Diana , Li Wenhui , Chen Shaolin , Werner Tomáš , Liesche Johannes 
Published: November 2024

SUMMARYThe rate of sucrose export from leaves is a major factor in balancing whole‐plant carbon and energy partitioning. A comprehensive study of its dynamics and relationship to photosynthesis, sink demand, and other relevant processes is hampered by the shortcomings of current methods for measuring sucrose phloem loading. We utilize the ability of sucrose transporter proteins, known as SUCs or SUTs, to specifically transport the fluorescent molecule esculin in a novel assay to measure phloem loading rates. Esculin was administered to source leaves and its fluorescence in the leaf extract was measured after 1 or 2 h. Dicot plants with an active phloem loading strategy showed an export‐dependent reduction of esculin fluorescence. Relative leaf esculin export rates correlated with leaf export rates of isotopic carbon and phloem exudate sucrose levels. We used esculin experiments to examine the effects of phytohormones on phloem loading in Arabidopsis, showing, for example, that auxin induces phloem loading while cytokinin reduces it. Transcriptional regulation of AtSUC2 by AUXIN RESPONSE FACTOR1 (ARF1) corroborated the link between auxin signaling and phloem loading. Unlike established methods, the esculin assay is rapid and does not require specialized equipment. Potential applications and limitations of the esculin assay are discussed.
Estimated Plasmodium18S ribosomal RNA prevalence in asymptomatic blood donors from three African countries
Authors: Tonnetti Laura , Groves Jamel A. , Self Deanna , Yadav Manisha C. , Tayou Tagny Claude , Rakoto Alson Olivat A. , Livezey Kristin , Linnen Jeffery M. , Stramer Susan L. 
Published: October 2024

AbstractBackground and ObjectivesThe World Health Organization (WHO) African Region accounts for 94% of malaria cases globally, with variability recognized within endemic regions. To determine the detection rate of Plasmodium RNA in blood donors resident in malaria‐endemic areas, samples from three African countries were tested using a Plasmodium nucleic acid test.Materials and MethodsWhole blood (WB) samples collected from routine donors in Cameroon, Madagascar and Mali were shipped frozen to the United States. Samples were tested individually from WB lysates with the Procleix Plasmodium assay (transcription‐mediated amplification [TMA]). Reactive samples were considered either repeat reactive or initial reactive only, depending on TMA‐retest results. When available, matching plasma samples were tested for Plasmodium antibodies by enzyme immunoassay (EIA).ResultsPlasmodium repeat reactivity ranged from 41% (91/223 tested) in Cameroon to 12% (26/216) in Mali and 1% (3/249) in Madagascar. Initially reactive samples, where reactivity did not repeat, were identified from Cameroon (5/223; 2%) and Mali (2/216; 1%). The matched‐plasma subgroup had EIA reactivity ranging from 86% (113/131 tested) in Cameroon to 59% (10/17) in Mali and 27% (68/248) in Madagascar.ConclusionPlasmodium ribosomal RNA (rRNA) detection and antibody rates varied greatly in the three countries studied. Detection of Plasmodium rRNA can provide an additional tool to address malaria risk in blood donors.
Bi-Level Interturn Short-Circuit Fault Monitoring for Wind Turbine Generators With Benchmark Dataset Development
Authors: Yan Jingyi , Senemmar Soroush , Zhang Jie 
Published: November 2024

Abstract
Flourished wind energy market pushes the latest wind turbines (WTs) to further and harsher inland and offshore environment. Increased operation and maintenance cost calls for more reliable and cost effective condition monitoring systems. In this article, a bi-level condition monitoring framework for interturn short-circuit faults (ITSCFs) in WT generators is proposed. A benchmark dataset, consisting of 75 ITSCF scenarios and generator current signals of a specific WT, has been created and made publicly available on Zenodo. The data are simulated at a rate of 4 kHz. Based on the time and frequency features extracted from data processing, machine learning-based severity estimation and faulty phase identification modules can provide valuable diagnostic information for wind farm operators. Specifically, the performance of long short-term memory (LSTM) networks, gated recurrent unit (GRU) networks, and convolutional neural networks (CNNs) are analyzed and compared for severity estimation and faulty phase identification. For test-bed experimental reference, various numbers of scenarios for training the models are analyzed. Numerical experiments demonstrate the computational efficiency and robust denoising capability of the CNN algorithm. The GRU network, however, achieves the highest accuracy. The overall system performance improves significantly, from 87.76% with 16 training scenarios to 99.95% with 52 training scenarios, when tested on a set containing all 76 scenarios from an unforeseen period.
Analytical Modeling of Bistable Beam With Double-Ring-Shaped Deformation Element
Authors: Patel Sandip T. , Dave Harshit K. 
Published: November 2024

Abstract
The field of negative stiffness structures has recently seen an increase in attention as a result of advancements in additive manufacturing (AM) technology. These advancements have made it possible to produce materials in a more expedient manner. The purpose of this research is to demonstrate a highly tunable and reusable bistable beam design that is based on a double-ring-shaped deformation element that undergoes pure bending, unlike traditional bistable mechanisms with buckling-based deformation elements. Further, an analytical model is developed and then validated by means of experimental and numerical results to precisely predict the snap-through behavior of a beam. It has been shown that the analytical model that was proposed has accuracy in terms of foreseeing the snap-through transition. A detailed study is conducted to explore the influence of geometric parameters on the snap-through characteristics. By carefully modifying these geometric properties, the required mechanical behavior of negative stiffness metamaterial (NSM) may be achieved for specific applications.