bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biholomorphic Mappings on Banach Spaces
Authors: Carrión H. , Galindo P. , Lourenço M. L. 
Published: February 2019

AbstractWe present an infinite-dimensional version of Cartan's theorem concerning the existence of a holomorphic inverse of a given holomorphic self-map of a bounded convex open subset of a dual Banach space. No separability is assumed, contrary to previous analogous results. The main assumption is that the derivative operator is power bounded, and which we, in turn, show to be diagonalizable in some cases, like the separable Hilbert space.
Miocene Glacial Dynamics Recorded by Variations in Magnetic Properties in the ANDRILL‐2A Drill Core
Authors: Jovane Luigi , Florindo Fabio , Acton Gary , Ohneiser Christian , Sagnotti Leonardo , Strada Eleonora , Verosub Kenneth L. , Wilson Gary S. , Iacoviello Francesco , Levy Richard H. , Passchier Sandra 
Published: February 2019

AbstractDuring the 2007 ANtarctic geological DRILLing (ANDRILL) campaign in the Ross Sea, Antarctica, the AND‐2A core was recovered through a stratigraphic succession spanning 1,138.54 m of Neogene sedimentary rocks that include an expanded early to middle Miocene sequence. The study reported here focuses on the magnetic properties of the interval from 778.63 m below sea floor (mbsf) to 1,138.54 mbsf, which comprises a time interval spanning 1.5 Myr, from ~18.7 to ~20.2 Ma. We recognize three main pulses of increased input of magnetic materials to the drill site between 778.34–903.06, 950.55–995.78, and 1,040–1,103.96 mbsf. Trends in the magnetic mineral concentration dependent parameters mirror changes in the proportion of sediments derived from McMurdo Volcanic Group rocks. We suggest that these pulses in magnetic mineral concentration reflect changes in sediment transport processes associated with changing glacial conditions at the drill site that included (1) subglacial and grounding zone proximal settings, (2) hemipelagic and neritic conditions with abundant sediment‐rich icebergs, and (3) grounding zone‐distal environment that was covered by land‐fast multiyear sea ice or a fringing ice shelf. The magnetic minerals record preserved in the AND‐2A core supports other data that indicate a highly dynamic and variable coastal environment during the early Miocene, where glaciers retreated inland under warm climatic conditions and advanced beyond the drill site across the continental shelf when cold climate prevailed.
Fluidized Appearing Ejecta on Ceres: Implications for the Mechanical Properties, Frictional Properties, and Composition of its Shallow Subsurface
Authors: Hughson Kynan H. G. , Russell C. T. , Schmidt B. E. , Chilton H. T. , Sizemore H. G. , Schenk P. M. , Raymond C. A. 
Published: February 2019

AbstractSeveral ejecta deposits on Ceres display morphological characteristics not commonly associated with dry ballistic emplacement. We characterized 30 examples of fluidized appearing ejecta (FAE) on Ceres and identified two distinct morphological populations: cuspate/lobate FAE and channelized FAE. The cuspate/lobate FAE typically display one or more of the following characteristics: well‐defined margins, a sheeted or layered appearance, arcuate or cuspate terminal lobes, and occasional mass concentrations at their distal margins. The channelized FAE typically display a morphology dominated by topographically focused channelized flows and arcuate terminal lobes but lack the well‐defined margins common among their cuspate/lobate counterparts. Although Cerean FAE are holistically distinct from rampart/layered ejecta craters on Mars, Ganymede, and other icy solar system objects, many of their aforementioned morphological characteristics are commonly found among these other examples of fluidized ejecta. The formation of Martian and icy satellite fluidized ejecta has been widely attributed to the mobilization of near‐surface volatiles, namely, water ice. The documented Cerean FAE are observed between absolute latitudes of 70°, with a slight enrichment in the midlatitudes of the southern hemisphere. We test the hypothesis that the morphologies and mobilities of Cerean FAE can be explained via impacting into a low‐cohesion ice‐silicate target material, followed by material sliding on a low‐friction partially icy substrate. We do this by comparing the observed Cerean FAE to a kinematic‐dynamic sliding ejecta emplacement model. We find that a mechanically weak, H2O‐rich near‐surface layer is consistent with the range of ejecta mobilities and morphologies observed in this investigation.
RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4
Authors: Hui Bingqing , Ji Hao , Xu Yetao , Wang Juan , Ma Zhonghua , Zhang Chongguo , Wang Keming , Zhou Yan 
Published: February 2019

AbstractLong noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2-AS1 as a relatively overexpressed lncRNA in PC tissues. qRT-PCR assays were performed to examine expression levels of AGAP2-AS1. MTT assays, colony formation assays, and EdU assays were used to determine the proliferative capacity of cells. Flow cytometry and TUNEL assays were used to study the regulation of AGAP2-AS1 in the cell cycle and apoptosis. Transwell experiments were used to study changes in cell invasion and metastasis, and a nude mouse model was established to assess the effects of AGAP2-AS1 on tumorigenesis in vivo. RNA sequencing was performed to probe AGAP2-AS1-related pathways. Subcellular fractionation and FISH assays were used to determine the distribution of AGAP2-AS1 in PC cells, and RIP and ChIP were used to determine the molecular mechanism of AGAP2-AS1-mediated regulation of potential target genes. Increased expression of AGAP2-AS1 was associated with tumor size and pathological stage progression in patients with PC. RREB1 was found to activate transcription of AGAP2-AS1 in PC cells. AGAP2-AS1 affected proliferation, apoptosis, cycle arrest, invasion, and metastasis of PC cells in vitro, and AGAP2-AS1 regulated PC proliferation in vivo. Furthermore, AGAP2-AS1 epigenetically inhibited the expression of ANKRD1 and ANGPTL4 by recruiting zeste homolog 2 (EZH2), thereby promoting PC proliferation and metastasis. In summary, our data show that RREB1-induced upregulation of AGAP2-AS1 regulates cell proliferation and migration in PC partly through suppressing ANKRD1 and ANGPTL4 by recruiting EZH2. AGAP2-AS1 represents a potential target for the diagnosis and treatment of PC in the future.
EMT is associated with an epigenetic signature of ECM remodeling genes
Authors: Peixoto Paul , Etcheverry Amandine , Aubry Marc , Missey Anaïs , Lachat Camille , Perrard Jérôme , Hendrick Elodie , Delage-Mourroux Régis , Mosser Jean , Borg Christophe , Feugeas Jean-Paul , Herfs Michaël , Boyer-Guittaut Michaël , Hervouet Eric 
Published: February 2019

AbstractType III epithelial–mesenchymal transition (EMT) has been previously associated with increased cell migration, invasion, metastasis, and therefore cancer aggressiveness. This reversible process is associated with an important gene expression reprogramming mainly due to epigenetic plasticity. Nevertheless, most of the studies describing the central role of epigenetic modifications during EMT were performed in a single-cell model and using only one mode of EMT induction. In our study, we studied the overall modulations of gene expression and epigenetic modifications in four different EMT-induced cell models issued from different tissues and using different inducers of EMT. Pangenomic analysis (transcriptome and ChIP–sequencing) validated our hypothesis that gene expression reprogramming during EMT is largely regulated by epigenetic modifications of a wide range of genes. Indeed, our results confirmed that each EMT model is unique and can be associated with a specific transcriptome profile and epigenetic program. However, we could select some genes or pathways that are similarly regulated in the different models and that could therefore be used as a common signature of all EMT models and become new biomarkers of the EMT phenotype. As an example, we can cite the regulation of gene-coding proteins involved in the degradation of the extracellular matrix (ECM), which are highly induced in all EMT models. Based on our investigations and results, we identified ADAM19 as a new biomarker of in vitro and in vivo EMT and we validated this biological new marker in a cohort of non-small lung carcinomas.
miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1
Authors: Han Jihua , Zhang Meiyin , Nie Chunlei , Jia Jinliang , Wang Fengyue , Yu Jiawei , Bi Wen , Liu Bo , Sheng Ruinan , He Guoqing , Kong Lingyu , Zheng Lingling , Pang Rui , Ding Zhaoming , Chen Lili , Guan Qiang , Pan Shangha , Meng Xianzhi , Xu Jin , Liu Lianxin , Zhang Jiewu 
Published: February 2019

AbstractThe incidence of papillary thyroid cancer (PTC) has been rapidly increasing in recent years. PTC is prone to lymph node metastasization, which further increases the recurrence rate and mortality of thyroid cancer. However, the underlying mechanisms of this process remain elusive. Several reports have shown that the microRNA miR-215 plays an important role in cancer metastasis. Here, we investigated, for the first time, the potential association between miR-215 and metastasis in PTC. The results of qPCR analysis demonstrated that miR-215 was downregulated in PTC cell lines and tissues, and lower levels of miR-215 correlated with lymph node metastasis of PTC. In vitro and in vivo assays revealed that restoration of miR-215 dramatically inhibited PTC cell proliferation and metastasis. We identified ADP ribosylation factor guanine nucleotide-exchange factor 1 (ARFGEF1) as the target, which mediated the function of miR-215. The expression of ARFGEF1 was inhibited by miR-215, and the effects of miR-215 were abrogated by re-expression of ARFGEF1. Moreover, we found that miR-215 suppressed PTC metastasis by modulating the epithelial–mesenchymal transition via the AKT/GSK-3β/Snail signaling. In summary, our study proves that miR-215 inhibits PTC proliferation and metastasis by targeting ARFGEF1 and indicates miR-215 as a biomarker for PTC prognosis.
Rice Blast Disease Recognition Using a Deep Convolutional Neural Network
Authors: Liang Wan-jie , Zhang Hong , Zhang Gu-feng , Cao Hong-xin 
Published: February 2019

AbstractRice disease recognition is crucial in automated rice disease diagnosis systems. At present, deep convolutional neural network (CNN) is generally considered the state-of-the-art solution in image recognition. In this paper, we propose a novel rice blast recognition method based on CNN. A dataset of 2906 positive samples and 2902 negative samples is established for training and testing the CNN model. In addition, we conduct comparative experiments for qualitative and quantitatively analysis in our evaluation of the effectiveness of the proposed method. The evaluation results show that the high-level features extracted by CNN are more discriminative and effective than traditional hand-crafted features including local binary patterns histograms (LBPH) and Haar-WT (Wavelet Transform). Moreover, quantitative evaluation results indicate that CNN with Softmax and CNN with support vector machine (SVM) have similar performances, with higher accuracy, larger area under curve (AUC), and better receiver operating characteristic (ROC) curves than both LBPH plus an SVM as the classifier and Haar-WT plus an SVM as the classifier. Therefore, our CNN model is a top performing method for rice blast disease recognition and can be potentially employed in practical applications.
Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair
Authors: Yang Wenting , Zhao Xinyuan , Tao Yuandong , Wu Yan , He Fuchu , Tang Li 
Published: February 2019

AbstractMacrophages are a heterogeneous population of immune cells that play central roles in a broad range of biological processes, including the resolution of inflammation. Although diverse macrophage subpopulations have been identified, the characterization and functional specialization of certain macrophage subsets in inflamed tissues remain unclear. Here we uncovered a key role of specific macrophage subsets in tissue repair using proteomics, bioinformatics and functional analysis. We isolated two hepatic monocyte-derived macrophage subpopulations: Ly6ChiCX3CR1lo macrophages and Ly6CloCX3CR1hi macrophages during distinct phases of acute liver injury and employed label-free proteomics approach to profile the proteome of these cells. We found that the endocytosis- and apoptotic cell clearance-related proteins were specifically enriched in Ly6CloCX3CR1hi macrophages at the resolution phase. Intriguingly, 12/15-lipoxygenase (Alox15), the most strongly up-regulated protein in Ly6CloCX3CR1hi macrophages, was identified as a specific marker for these macrophages. In co-culture systems, Ly6CloCX3CR1hi macrophages specifically induced hepatocyte proliferation. Furthermore, selective depletion of this population in CD11b-diphtheria toxin receptor mice significantly delayed liver repair. Overall, our studies shed light on the functional specialization of distinct macrophage subsets from different phases in the resolution of inflammation.
Cytoprotective effects of Avenathramide C against oxidative and inflammatory stress in normal human dermal fibroblasts
Authors: Wang Chenxuan , Eskiw Christopher H. 
Published: February 2019

AbstractNatural polyphenols are promising anti-aging compounds not only for their antioxidant activity, but also their ability to activate specific cellular pathways mediating the aging process. Avenanthramide C (Avn C), found exclusively in oats, is a natural antioxidant associated with free radical scavenging; however, it is how this compound elicits other protective effects. We investigated the intracellular antioxidant activity of Avn C and other cytoprotective potential in normal human skin fibroblasts exposed to extracellular stress. Avn C reduced H2O2-induced oxidative stress by reducing intracellular free radical levels and antioxidant gene transcripts. Avn C also resulted in decreased levels of gene transcripts encoding pro-inflammatory cytokines in response to H2O2 or tumor necrosis factor-α (TNF-α). This reduction in cytokine gene transcription occurred concomitantly with reduced phosphorylated nuclear factor-κB (NF-κB) p65, and decreased NF-κB DNA binding. Avn C further induced heme oxygense-1 (HO-1) expression through increased Nrf2 DNA binding activity, demonstrating a second mechanism by which Avn C attenuates cellular stress. Collectively, our findings indicate that Avn C protects normal human skin fibroblasts against oxidative stress and inflammatory response through NF-κB inhibition and Nrf2/HO-1 activation.
Metabolomic and transcriptomic changes underlying cold and anaerobic stresses after storage of table grapes
Authors: Maoz Itay , De Rosso Mirko , Kaplunov Tatiana , Vedova Antonio Dalla , Sela Noa , Flamini Riccardo , Lewinsohn Efraim , Lichter Amnon 
Published: February 2019

AbstractThe currently accepted paradigm is that fruits and vegetables should be consumed fresh and that their quality deteriorates during storage; however, there are indications that some metabolic properties can, in fact, be improved. We examined the effects of low temperature and high-CO2conditions on table grapes,Vitis viniferaL. cv. ‘Superior Seedless’. Berries were sampled at harvest (T0) and after low-temperature storage for 6 weeks under either normal atmosphere conditions (TC) or under an O2level of 5 kPa and elevated CO2levels of 5, 10 or 15 kPa (T5, T10, T15). Accumulation of 10 stilbenes, includingE-ε-viniferin,E-miyabenol C and piceatannol, significantly increased under TC treatment as compared to T0 or T15. Sensory analysis demonstrated that elevated CO2elicited dose-dependent off-flavor accumulation. These changes were accompanied by an accumulation of 12 volatile metabolites, e.g., ethyl acetate and diacetyl, that imparted disagreeable flavors to fresh fruit. Transcriptome analysis revealed enrichment of genes involved in pyruvate metabolism and the phenylpropanoid pathway. One of the transcription factors induced at low temperature but not under high CO2wasVvMYB14, which regulates stilbene biosynthesis. Our findings reveal the potential to alter the levels of targeted metabolites in stored produce through understanding the effects of postharvest treatments.
Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia
Authors: Chen Pinhong , Ye Enmao , Jin Xiao , Zhu Yuyang , Wang Lubin 
Published: February 2019

AbstractCognitive deficits are considered a core component of schizophrenia and may predict functional outcome. However, the neural underpinnings of neuropsychological impairment remain to be fully elucidated. Data of 59 schizophrenia patients and 72 healthy controls from a public resting-state fMRI database was employed in our study. Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery was used to measure deficits of cognitive abilities in schizophrenia. Neural correlates of cognitive deficits in schizophrenia were examined by linear regression analysis of the thalamocortical network activity with scores of seven cognitive domains. We confirmed the combination of reduced prefrontal-thalamic connectivity and increased sensorimotor-thalamic connectivity in patients with schizophrenia. Correlation analysis with cognition revealed that in schizophrenia (1) the thalamic functional connectivity in the bilateral pre- and postcentral gyri was negatively correlated with attention/vigilance and speed of processing (Pearson’s r ≤ −0.443, p ≤ 0.042, FWE corrected), and positively correlated with patients’ negative symptoms (Pearson’s r ≥ 0.375, p ≤ 0.003, FWE corrected); (2) the thalamic functional connectivity in the right cerebellum was positively correlated with speed of processing (Pearson’s r = 0.388, p = 0.01, FWE corrected). Our study demonstrates that thalamic hyperconnectivity with sensorimotor areas is related to the severity of cognitive deficits and clinical symptoms, and extends our understanding of the neural underpinnings of “cognitive dysmetria” in schizophrenia.
Standardized assay for assessment of minimal residual disease in blood, bone marrow and apheresis from patients with plasma cell myeloma
Authors: Blum Agnieszka , Haussmann Katy , Streitz Mathias , Schlickeiser Stephan , Tietze-Buerger Carola , Blau Igor Wolfgang , Uharek Lutz 
Published: February 2019

AbstractThe recent advances in myeloma treatment result in significantly better outcomes, defined as increased progression free survival (PFS) and overall survival (OS). Since there is a proven correlation between the extend of response and prolonged survival, there is an urgent need for highly sensitive assays for the detection of minimal residual disease (MRD). Next generation flow cytometry has become a valuable approach for sensitive evaluation of the depth of complete response (CR). Here, we report the diagnostic performance and validation results of a single-tube 9-color panel assay. The validation design included intra-assay analysis measuring accuracy, inter-assay analysis estimating method’s linearity and precision and inter-assay analysis evaluating repeatability. Furthermore, in inter-operator analysis assessed the comparability of the result analysis of different operators. Staining stability was evaluated in age-of-stain experiments. Our validation results show that a reliable detection of residual myeloma cells is feasible to a detection level of 10−5with a single-tube assay for a variety of materials (peripheral blood, bone marrow and stem cell apheresis). This study establishes highly sensitive, fully standardized approach for MRD detection in myeloma that is ready for implementation in routine diagnostic laboratories.
Testing a Cognitive Control Model of Human Intelligence
Authors: Chen Yu , Spagna Alfredo , Wu Tingting , Kim Tae Hyeong , Wu Qiong , Chen Caiqi , Wu Yanhong , Fan Jin 
Published: February 2019

AbstractThe definition of human intelligence and its underlying psychological constructs have long been debated. Although previous studies have investigated the fundamental cognitive functions determining intellectual abilities, such as the broadly defined executive functions including working memory, the core process has yet to be identified. A potential candidate for such a role might be cognitive control, a psychological construct for the coordination of thoughts and actions under conditions of uncertainty. In this study, we tested a cognitive control model of intellectual ability by examining the association between cognitive control, measured by a perceptual decision-making task and by the attention network test, and general intelligence including components of fluid intelligence (Gf, concerning the ability to solve problems by abstraction) and crystalized intelligence (Gc, related to learning from prior knowledge and experience) measured by the Wechsler Adult Intelligence Scale. We also examined the potential role of cognitive control as a core process involved in another determinant of intellectual abilities, the working memory, measured by the N-back tasks and the working memory complex span tasks. The relationship among intelligence, cognitive control, and working memory was examined using structural equation modeling. Results showed that cognitive control shared a large amount of variance with working memory and both measures were strongly associated with Gf and Gc, with a stronger association with Gf than Gc. These findings suggest that cognitive control, serving as a core construct of executive functions, contributes substantially to general intellectual ability, especially fluid intelligence.
Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis
Authors: Shi J. , Li J. , Su W. , Zhao S. , Li H. , Lei L. 
Published: February 2019

AbstractPeriodontal homeostasis is maintained by the dynamic equilibrium between cell death, differentiation and proliferation of resident cells in the periodontal microenvironment. Loss of resident periodontal ligament fibroblasts (PDLFs) has been a major challenge in the periodontal treatment. This study aimed to investigate the exact role of necroptotic cell death in periodontal diseases. Elevated levels of receptor-interacting protein serine-threonine kinases -1 (RIPK1), phosphorylated RIPK3, mixed lineage kinase domain-like protein (MLKL), phosphorylated MLKL and FLIPL were observed in gingival tissues collected from patients with untreated chronic periodontitis; whereas no difference in caspase 8 was observed between the periodontitis and healthy control group. In contrast to the high incidence of necroptotic cell death in monocytes during live P. gingivalis infection with a low multiplicity of infection (MOI), necroptosis was only observed in PDLFs with a high MOI. Priming PDLFs with frozen thawed monocytes enhanced proinflammatory responses to P. gingivalis infection; moreover, frozen thawed monocytes stimulation triggered RIPK1, RIPK3 and MLKL-mediated-necroptotic cell death in PDLFs. These results indicated that RIPK3 and MLKL-mediated-necroptotic cell death participated in the pathogenesis of periodontitis, and DAMPs released from monocytes after P. gingivalis stimulation by necroptosis triggered not only inflammatory responses, but also necroptosis of PDLFs.