bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perﬁl dos pacientes diagnosticados com displasia do desenvolvimento do quadril
Authors: Barbosa Renan de Oliveira , Albernaz Elaine Pinto 
Published: April 2018

Resumo
Objetivo Descrever o perﬁl dos pacientes com displasia do desenvolvimento do quadril (DDQ), diagnosticados por meio de exame físico e ultrassonográﬁco, com a implantação do protocolo de atenção e rastreio de DDQ.
Métodos Estudo transversal que incluiu os portadores de DDQ nascidos de janeiro de 2014 a dezembro de 2016, na cidade de Pelotas, Sul do Brasil, que considerou os fatores etnia, sexo, peso ao nascer, posição fetal, lado de ocorrência, idade gestacional, idade materna e histórico familiar. Os dados de prontuário foram comparados com as características da população geral por meio do Sistema de Informação sobre Nascidos Vivos (Sinasc).
Resultados Foram identiﬁcados 33 portadores de DDQ, a maioria do sexo feminino, que mostrou uma probabilidade quatro vezes maior de apresentar a patologia (p < 0,001), e o lado mais acometido foi o esquerdo. Os recém-nascidos com apresentação pélvica tiveram uma probabilidade 15 vezes maior de ter DDQ (p < 0,001). Não foi encontrada associação estatisticamente signiﬁcativa com os seguintes fatores avaliados: peso ao nascer, idade gestacional, etnia e idade materna. Um total de 21 recém-nascidos necessitaram de tratamento imediato do quadril; a ecograﬁa demonstrou classiﬁcação IIb ou maior, pelo método de Graf, ou a radiograﬁa mostrou luxação nos portadores de DDQ com mais de seis meses de idade.
Conclusão O rastreio de DDQ é essencial em todos os recém-nascidos, e o exame físico, quando alterado, deve ser complementado com o ultrassonográﬁco para evitar o diagnóstico tardio da doença.
Absence of Saharan dust influence on the strontium isotope ratios on modern trees from the Bahamas and Turks and Caicos Islands
Authors: Schulting Rick , Richards Mike , Pouncett John , Manco Bryan Naqqi , Freid Ethan , Ostapkowicz Joanna 
Published: April 2018

AbstractWe report on strontium (87Sr/86Sr) isotope results from 91 modern trees growing on the Bahamas and Turks and Caicos Islands. The average87Sr/86Sr ratio of 0.709169±0.000010 is consistent with the late Quaternary limestone of the islands and with the modern ocean value. The absence of any detectable influence of87Sr-enriched Saharan dust is notable, given the known contribution of this material to both past and recent soils of the Caribbean. Our results indicate that the impact of Saharan dust to the modern biosphere of the Bahamian archipelago is at least an order of magnitude less than modeled in currently available strontium isoscapes for the circum-Caribbean. We suggest that the bioavailability of Sr in Saharan dust may be considerably less than previously thought. Nevertheless, further work could usefully be carried out in the Bahamian archipelago on plants with different rooting depths, growing on different soil types and on limestone of different ages. Our results have particular relevance for the refinement of existing strontium isoscapes and the archaeological provenience of artifacts, animals, and people in the circum-Caribbean.
Increased frequency of torrential rainstorms during a regional late Holocene eastern Mediterranean drought
Authors: Ahlborn Marieke , Armon Moshe , Ben Dor Yoav , Neugebauer Ina , Schwab Markus J. , Tjallingii Rik , Shoqeir Jawad Hasan , Morin Efrat , Enzel Yehouda , Brauer Achim 
Published: April 2018

AbstractIdentifying climates favoring extreme weather phenomena is a primary aim of paleoclimate and paleohydrological research. Here, we present a well-dated, late Holocene Dead Sea sediment record of debris flows covering 3.3 to 1.9 cal ka BP. Twenty-three graded layers deposited in shallow waters near the western Dead Sea shore were identified by microfacies analysis. These layers represent distal subaquatic deposits of debris flows triggered by torrential rainstorms over the adjacent western Dead Sea escarpment. Modern debris flows on this escarpment are induced by rare rainstorms with intensities exceeding >30 mm h−1for at least one hour and originate primarily from the Active Red Sea Trough synoptic pattern. The observed late Holocene clustering of such debris flows during a regional drought indicates an increased influence of Active Red Sea Troughs resulting from a shift in synoptic atmospheric circulation patterns. This shift likely decreased the passages of eastern Mediterranean cyclones, leading to drier conditions, but favored rainstorms triggered by the Active Red Sea Trough. This is in accord with present-day meteorological data showing an increased frequency of torrential rainstorms in regions of drier climate. Hence, this study provides conclusive evidence for a shift in synoptic atmospheric circulation patterns during a late Holocene drought.
THE ORIGINS OF TRADESCANT’S ‘INDIA OCCIDENTALI’ WOODEN CLUBS:14C DATING, MATERIAL IDENTIFICATION AND STRONTIUM ISOTOPE STUDIES
Authors: Ostapkowicz Joanna , Roberts Alison , Thistlewood Jevon , Brock Fiona , Wiedenhoeft Alex C , Snoeck Christophe , Schulting Rick , Bray Warwick 
Published: April 2018

This paper focuses on the material study (radiocarbon dating, wood identification and strontium isotope analyses) of four large ‘India occidentali’ clubs, part of the founding collections of the Ashmolean Museum, in Oxford, and originally part of John Tradescant’s ‘Ark’, in Lambeth (1656). During the seventeenth century, the term ‘India occidentali/occidentales’ referred not only to the ‘West Indies’ (its literal translation), but to the Americas as a whole; hence, the Ashmolean clubs and, indeed, thecforty examples of similarly large, decorated clubs known in international museum collections had no firm provenance and lacked even the most basic information. Previous attempts at attribution, based on stylistic comparisons with nineteenth- to twentieth-century Brazilian and Guyanese clubs, have proved inconclusive given the unique features of this club style, raising the intriguing possibility that these may be exceptionally rare examples of ‘Island Carib’ (Kalinago) material culture, particularly as images of such clubs appear in seventeenth-century ethnographic accounts from the Lesser Antilles. This paper provides new data for these poorly known objects from early collections, revealing not only the type of wood from which they were carved (Platymisciumsp. andBrosimumcfguianense) and their probable dates of manufacture (c AD1300–1640), but also their possible provenance (strontium results are consistent with a possible range from Trinidad south to French Guiana).
Grounding responsibility in something (more) solid
Authors: Hirstein William , Sifferd Katrina 
Published: April 2018

AbstractThe cases that Doris chronicles of confabulation are similar to perceptual illusions in that, while they show the interstices of our perceptual or cognitive system, they fail to establish that our everyday perception or cognition is not for the most part correct. Doris's account in general lacks the resources to make synchronic assessments of responsibility, partially because it fails to make use of knowledge now available to us about what is happening in the brains of agents.
Collaborating agents: Values, sociality, and moral responsibility
Authors: Doris John M. 
Published: April 2018

AbstractI respond to the Behavioral and Brain Sciences commentaries on my book, Talking to Our Selves: Reflection, Ignorance, and Agency. I defend and amend both the skeptical challenge to morally responsible agency, that is, the book's impetus, and the anti-skeptical theory I develop to address that challenge. Regarding the skeptical challenge, I argue that it must be taken more seriously than some of my sanguine commentators assert, and consider some ways its impact might be blunted, such as by appeal to individual differences and the practical efficacy of human behavior. Regarding my positive theory, I defend the role of values in morally responsible agency against numerous criticisms, and consider various suggestions for elaborating my social, “collaborativist” account of morally responsible agency. In closing, I comment on the appropriate aspirations for theorizing about moral responsibility and agency.
Segmentation of design protocol using EEG
Authors: Nguyen Philon , Nguyen Thanh An , Zeng Yong 
Published: April 2018

AbstractDesign protocol data analysis methods form a well-known set of techniques used by design researchers to further understand the conceptual design process. Verbal protocols are a popular technique used to analyze design activities. However, verbal protocols are known to have some limitations. A recurring problem in design protocol analysis is to segment and code protocol data into logical and semantic units. This is usually a manual step and little work has been done on fully automated segmentation techniques. Physiological signals such as electroencephalograms (EEG) can provide assistance in solving this problem. Such problems are typical inverse problems that occur in the line of research. A thought process needs to be reconstructed from its output, an EEG signal. We propose an EEG-based method for design protocol coding and segmentation. We provide experimental validation of our methods and compare manual segmentation by domain experts to algorithmic segmentation using EEG. The best performing automated segmentation method (when manual segmentation is the baseline) is found to have an average deviation from manual segmentations of 2 s. Furthermore, EEG-based segmentation can identify cognitive structures that simple observation of design protocols cannot. EEG-based segmentation does not replace complex domain expert segmentation but rather complements it. Techniques such as verbal protocols are known to fail in some circumstances. EEG-based segmentation has the added feature that it is fully automated and can be readily integrated in engineering systems and subsystems. It is effectively a window into the mind.
A highly selective UWB bandpass filter using stepped impedance stubs
Authors: Jung Minjae , Min Byung-Wook 
Published: April 2018

AbstractWe present a new ultra-wideband (UWB) band-pass filter (BPF) configuration with a stepped impedance short-circuited stub (SISS)-loaded triple-mode resonator (TMR) and stepped impedance radial stub (SIRS). The novel SISS-loaded TMR and SIRS improve the roll-off ratio at both ends. Even though this UWB BPF is based on a single resonator, the measured results show excellent in-band performance with a small insertion loss less than 0.6 dB and return loss greater than −16 dB. The proposed UWB BPF has sharp roll-off ratio of 96 and 43 dB/GHz, respectively, at the lower and upper edges of the pass-band, and a wide stop-band from 10.8 to 15.6 GHz with the rejection greater than 20 dB.
Analysis of multipath and DOA detection using a fully polarimetric automotive radar
Authors: Visentin Tristan , Hasch Jürgen , Zwick Thomas 
Published: April 2018

AbstractMultipath propagation occurs in many situations of radar measurements in complex environments. The unwanted effects range from interference over the radar channels, which causes amplitude fading and a corrupted direction of arrival (DOA) estimation, to the detection of ghost targets in an angle of arrival of the multipath direction. Due to the different number of reflections, polarimetric radars are capable to separate certain multipaths from direct paths if the target is known in advance. Furthermore, it is possible to separate objects with different polarimetric features in DOA that are located in the same radial distance to the radar. In this paper, a new approach to DOA detection based on the coherent Pauli decomposition is presented. With this approach, important multipath and DOA effects are analyzed and measurement results at 77 GHz on canonical objects in an anechoic chamber are presented. The results prove the feasibility of the approach and demonstrate the occurring effects.
A metamaterial absorber based high gain directional dipole antenna
Authors: Pushpakaran Sarin Valiyaveettil , Purushothama Jayakrishnan M. , Mani Manoj , Chandroth Aanandan , Pezholil Mohanan , Kesavath Vasudevan 
Published: April 2018

AbstractA novel idea for generating directional electromagnetic beam using a metamaterial absorber for enhancing radiation from a microwave antenna in the S-band is presented herewith. The metamaterial structure constitutes the well-known stacked dogbone doublet working in the absorption mode. The reflection property of the dogbone metamaterial absorber, for the non-propagating reactive near-field, is utilized for achieving highly enhanced and directional radiation characteristics. The metamaterial absorber converts the high-spatial reactive spectrum in the near-field into propagating low-spatial spectrum resulting in enhanced radiation efficiency and gain. The gain of a printed standard half-wave dipole is enhanced to 10 dBi from 2.3 dBi with highly directional radiation characteristics at resonance.
Herztransplantation und „Destination“-Therapie – Update 2018
Authors: Saeed Diyar , Westenfeld Ralf 
Published: April 2018

Was ist neu?
Zurückhaltung bei der Organspende Der auch im vergangenen Jahr deutliche Rückgang der Bereitschaft zur Organspende hat Auswirkungen auf die Therapie der terminalen Herzinsuffizienz. Wenn auch die Herztransplantation weiterhin den Goldstandard darstellt, kann infolge des Organmangels nur ein geringer und zumeist schwersterkrankter Anteil der Wartelistenpatienten, sogenannte „high-urgent“-Kandidaten mit einem Spenderorgan versorgt werden.
Listung zur Herztransplantation und Kunstherzversorgung Für die Indikationsstellung zur Listung wie zur Kunstherzversorgung gelten ähnliche Kriterien. Aktuelle Leitlinien betonen die valide Aussagekraft von Überlebens-Scores wie dem Heart Failure Survival Score oder dem Seattle Heart Failure Model als Indikator einer kritisch verkürzten Überlebenszeit im Vergleich zu den aufwendiger zu erhebenden etablierten Grenzwerten einer reduzierten spiroergometrischen Belastbarkeit.
Lebenserwartung nach Herztransplantation Im Eurotransplant-Raum liegt die Lebenserwartung nach Herztransplantation seit Jahren stabil im Mittel bei 11 Jahren (1-Jahresüberleben: 80 %). Das durchschnittliche Spenderalter liegt bei 45 Jahren im Vergleich zu deutlich jüngeren 25 Jahren in den USA.
Überleben nach LVAD-Implantation Das Überleben hat sich mit dem Umstieg von pulsatilen auf kontinuierliche Pumpensysteme und parallel zu technischen Innovationen verbessert, sodass das aktuelle 1-Jahresüberleben mit 80 % dem der Herztransplantation ebenbürtig ist. Komplikationen im Langzeitverlauf sind Blutungskomplikationen und Driveline-Infekte. Schlaganfälle (ischämisch und hämorrhagisch) sind mit den aktuellen Systemen auf etwa 3 Fälle in 100 Patientenmonaten reduziert.
Indikationsstellung zur dauerhaften LVAD-Versorgung Besondere Gesichtspunkte beinhalten die Charakterisierung der Rechtsherzfunktion und einer möglichen Aorteninsuffizienz, die bei der Technik der Implantation zu berücksichtigen sind (transiente Rechtsherzunterstützung, bzw. Bioaortenklappenersatz).
Ausblick In der Zukunft werden die begrenzten Organe wahrscheinlich nicht nur nach der Dringlichkeit (berechnet nach der kalkulierten Wartelistensterblichkeit) sondern auch unter Berücksichtigung des zu erwartenden Transplantationserfolges vergeben, die beide im sogenannten Cardiac Allocation Score (CAS) verknüpft sind und mit dessen Implementation ab Mitte 2018 wieder vermehrt elektive Wartelistenpatienten auf ein Spenderherz hoffen könnten.
Neues zur Labordiagnostik bei ANCA-assoziierten Vaskulitiden
Authors: Csernok Elena 
Published: April 2018

Was ist neu?
Relevanz der Detektionsmethoden Als Standard zum Nachweis von antineutrophilen zytoplasmatischen Antikörpern (ANCA) galt bis dato die indirekte Immunfluoreszenz (IIF) gefolgt von PR3- und/oder MPO-ANCA-Immunoassay. Neuere Studien haben allerdings gezeigt, dass die Verwendung von antigenspezifischen Immunoassays als einzigem Diagnoseschritt eine bessere Option darstellt.
Aktuelle Entwicklungen in der ANCA-Methodik Neben ELISA sind heute neue Festphasentechnologien (ALBIA, CLIA, FEIA, LIA/DIA) und automatisierte IIF-Assays verfügbar. Derzeit erhältliche Immunoassays für PR3- und MPO-ANCA sind hoch sensitiv und hochspezifisch für die Diagnose einer GPA und MPA.
EUVAS-Studie zur Evaluation von ANCA IIF und antigen-spezifischer Immunoassays In einer aktuellen multizentrischen Studie der European Vasculitis Study Group (EUVAS) wurde die Bedeutung der IIF-Methode im Vergleich zu antigenspezifischen Immunoassays für den ANCA-Nachweis untersucht. Die Ergebnisse bestätigen, dass die diagnostische Wertigkeit der PR3- und MPO-ANCA-Immunoassays der IIF überlegen ist. Auf Basis dieser Daten wurden jüngst neue Leitlinien zur ANCA-Testung erarbeitet.
Neue Konsensus zur ANCA-Diagnostik Die neue internationale Konsensus-Empfehlung wurde 2017 erarbeitet. Sie beinhaltet, dass PR3- und MPO-ANCA-Immunoassays für die korrekte Diagnosestellung bei AAV ohne die Notwendigkeit einer zusätzlichen IIF eingesetzt werden können.
Rationaler Einsatz der ANCA-Testung Wegen der ausgesprochenen Seltenheit der AAV spielt die Vortestwahrscheinlichkeit bei der ANCA-Diagnostik eine besonders große Rolle. ANCA sollten demnach nur bei einer mindestens mittleren Vortestwahrscheinlichkeit eingesetzt werden, d. h. wenn ein klinisch begründeter Verdacht auf das Vorliegen einer Vaskulitis besteht.
Identification of Non-Zinc Binding Inhibitors of MMP-2 Through Virtual Screening and Subsequent Rescoring
Authors: Shamsara Jamal 
Published: April 2018

AbstractMMP-2 belongs to a large family of proteases called matrix metalloproteinases (MMPs) that degrades type IV collagen, the main structural component of basement membranes and gelatin. The main pathologic role of MMP-2 overexpression is to contribute to the development of cancer through the progression of metastasis and angiogenesis. A structure-based virtual screening was employed to find new inhibitors with possible selectivity for MMP-2. The inhibitory activities of 3 inhibitors (one was not a suitable drug-like hit) among 19 purchased compounds were approved by enzyme inhibition assay. 5 hits were non-zinc-binding inhibitors of MMP-2. The results demonstrated that a computer-aided drug design could be successfully applied for discovering new MMP-2 inhibitors. We found inhibitors with new scaffolds for the inhibition of MMP-2 with some selectivity features that could be used for future lead optimization processes. According to the docked pose and MD simulation, compound 13 was expected to interact with the S1′ specificity loop of MMP-2 and had 2 π–π interactions and a stable hydrogen bond with the MMP-2 active site. The key feature of compound 13 could be used to guide the design of new non-zinc-binding inhibitors of MMP-2.
Prediction of Post-Discharge Bleeding in Elderly Patients with Acute Coronary Syndromes: Insights from the BleeMACS Registry
Authors: Garay Alberto , Formiga Francesc , Raposeiras-Roubín Sergio , Abu-Assi Emad , Sánchez-Salado José , Lorente Victòria , Alegre Oriol , Henriques Jose , D'Ascenzo Fabrizio , Saucedo Jorge , González-Juanatey José , Wilton Stephen , Kikkert Wouter , Nuñez-Gil Iván , Song Xiantao , Alexopoulos Dimitrios , Liebetrau Christoph , Kawaji Tetsuma , Moretti Claudio , Huczek Zenon , Nie Shao-Ping , Fujii Toshiharu , Correia Luis , Kawashiri Masa-aki , García-Acuña José , Southern Danielle , Alfonso Emilio , Terol Belén , Zhang Dongfeng , Chen Yalei , Xanthopoulou Ioanna , Osman Neriman , Möllmann Helge , Shiomi Hiroki , Giordana Francesca , Gaita Fiorenzo , Kowara Michal , Filipiak Krzysztof , Wang Xiao , Yan Yan , Fan Jing-Yao , Ikari Yuji , Nakahashi Takuya , Sakata Kenji , Yamagishi Masakazu , Kalpak Oliver , Kedev Sasko , Cequier Angel , Ariza-Solé Albert 
Published: April 2018

Background A poor ability of recommended risk scores for predicting in-hospital bleeding has been reported in elderly patients with acute coronary syndromes (ACS). No study assessed the prediction of post-discharge bleeding in the elderly. The new BleeMACS score (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome), was designed to predict post-discharge bleeding in ACS patients. We aimed to assess the predictive ability of the BleeMACS score in elderly patients.
Methods We assessed the incidence and characteristics of severe bleeding after discharge in ACS patients aged ≥ 75 years. Bleeding was defined as any intracranial bleeding or bleeding leading to hospitalization and/or red blood transfusion, occurring within the first year after discharge. We assessed the predictive ability of the BleeMACS score according to age by Fine–Gray proportional hazards regression analysis, calculating receiver-operating characteristic (ROC) curves and the area under the ROC curves (AUC).
Results The BleeMACS registry included 15,401 patients of whom 3,376/15,401 (21.9%) were aged ≥ 75 years. Elderly patients were more commonly treated with clopidogrel and less often treated with ticagrelor or prasugrel. Of 3,376 elderly patients, 190 (5.6%) experienced post-discharge bleeding. The incidence of bleeding was moderately higher in elderly patients (hazard ratio [HR], 2.31, 95% confidence interval [CI], 1.92–2.77). The predictive ability of the BleeMACS score was moderately lower in elderly patients (AUC, 0.652 vs. 0.691, p = 0.001).
Conclusion Elderly patients with ACS had a significantly higher incidence of post-discharge bleeding. Despite a lower predictive ability in older patients, the BleeMACS score exhibited an acceptable performance in these patients.
Type of Combined Contraceptives, Factor V Leiden Mutation and Risk of Venous Thromboembolism
Authors: Hugon-Rodin Justine , Horellou Marie-Hélène , Conard Jacqueline , Gompel Anne , Plu-Bureau Geneviève 
Published: April 2018

Objective This article estimates the interaction between types of combined hormonal contraception (CHC) and factor V Leiden (FVL) mutation on the risk of venous thrombosis event (VTE).
Subjects and Methods All premenopausal women with first incident VTE who were referred to our unit (Paris, France) between 2000 and 2009 were included in this case-only study. Differences in interactions by progestin type were assessed on a multiplicative scale, assuming the independence of genotype and prescription of type of CHC.
Results Among 2,613 women with VTE, 15.9% had a FVL and 69% used CHC. The interaction between CHC use and presence of FVL on VTE risk was statistically significant (1.37, 1.06–1.77 95% confidence interval [CI]). This interaction appeared higher for drospirenone 1.99 (1.18–3.38 95% CI) (n = 98) or cyproterone acetate users 1.71 (1.20–2.45 95% CI) (n = 326), but not significant for 1st or 2nd or norgestimate CHC users. The results were similar when excluding women with a family history of VTE or with provoked VTE. In this sub-group of women, these interactions appeared higher for third generation, cyproterone acetate and drospirenone CHC users as compared with 1st or 2nd or norgestimate CHC users (odds ratio [OR], 1.68 [1.04–2.70; 95% CI], 2.91 [1.71–4.95 95% CI], 3.22 [1.54–6.73 95% CI], respectively).
Conclusion Our results show that the interaction between FVL and CHC use differ by progestin type, which is higher in CHC containing third-generation progestin, drospirenone or cyproterone acetate, compared with second generation. Further studies are needed to assess the cost-effectiveness of biological thrombophilia screening (FVL) when such prescription of CHC is planned.