bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alerta Rosa: Novel Alert and Navigation Breast Cancer Program in Nuevo Leon, Mexico, for Reducing Health System Interval Delays
Authors: Mireles-Aguilar Teresa , Tamez-Salazar Jaime , Muñoz-Lozano Jose F. , Lopez-Martinez Edna A. , Romero Cristina , Platas Alejandra , Villarreal-Garza Cynthia 
Published: August 2018

Abstract

Background
In Mexico, the median time between breast cancer (BC) symptom detection and treatment initiation is approximately 7 months. Alerta Rosa is a program that was developed with the intent of breaking down medical care barriers and reduce delays.

Patients and Methods
Through several media campaigns, we reached out to patients with breast symptoms or abnormal imaging studies. Patients contacted our call center or Facebook page. A navigator recorded their main complaint and scheduled a medical consultation with a specialist. We prioritized patients according to clinical risk. Those diagnosed with BC were referred to their health affiliation unit for care.

Results
To date, 656 patients have contacted our program. Median age was 44 years (range, 7–82). Patients reported becoming aware of Alerta Rosa mainly by word of mouth and TV. A total of 446 medical consultations were scheduled, and 309 patients attended their appointments. A biopsy procedure was solicited for 39 patients, and 22 were diagnosed with BC. Most patients had stage II (45%) or stage III (32%) disease. The median time from alert activation to treatment initiation was 33 days (range, 19–56) and from first medical evaluation to treatment initiation was 28 days (range, 16–48).

Conclusion
In low- or middle-income countries, where BC screening programs do not effectively reach the target population, it is crucial to focus efforts in identifying and prioritizing symptomatic patients or those with abnormal imaging studies to ultimately downstage BC. Alerta Rosa proved to be successful in reducing health system intervals and could be replicated and adapted for other limited resource settings.

Implications for Practice
In countries such as Mexico, infrastructure and financial drawbacks limit the implementation of effective screening mammography programs. This article presents a novel and effective alternative to optimize resources and reduce health system intervals, so that patients in limited-resource settings can have access to prompt quality care. This strategy for early breast cancer detection focused efforts in prioritizing symptomatic women and those with abnormal breast imaging studies. This article presents novel information that will be useful for the development of effective early breast cancer detection with a focus on opportunistic rather than population-screening mammography in low-resource settings.
Osimertinib for EGFR-Mutant Lung Cancer with Brain Metastases: Results from a Single-Center Retrospective Study
Authors: Xie Lijia , Nagpal Seema , Wakelee Heather A. , Li Gordon , Soltys Scott G. , Neal Joel W. 
Published: August 2018

Abstract

Introduction
Osimertinib is a third-generation tyrosine kinase inhibitor, initially approved for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) with T790M acquired resistance, and now approved in the first-line setting. However, data supporting the use of osimertinib in untreated brain metastases are limited, although it has established central nervous system (CNS) activity. Our study compares the clinical outcomes of patients experiencing progressing brain metastases treated with cranial irradiation and osimertinib with those treated with osimertinib alone.

Methods
Forty patients who were treated with osimertinib at the Stanford Cancer Center from November 2015 to December 2016 were identified by searching an electronic medical record database. Eleven patients had progressing brain metastases and did not receive radiation (group A), 9 patients had progressing brain metastases and received radiation when starting osimertinib (group B), and 20 patients had stable brain metastases at the time of initiating osimertinib (group C). Patient and disease characteristics, radiographic responses, and survival outcomes were evaluated retrospectively for the three groups.

Results
The CNS response rate was 32.3%. Median time to treatment failure (TTF), overall progression-free survival (PFS), and overall survival (OS) were 10.0 months (95% confidence interval [CI], 4.5–11.8), 8.8 months (95% CI, 6.2–12.1), and 16.2 months, respectively. Median TTF was 15.1 months for group A (95% CI, 1.7–28.5), 7.7 months for group B (95% CI, 0–15.5), and 10.7 months for group C (95% CI, 9.0–12.5). The median PFS was 8.8 months for group A (95% CI, 4.3–13.4), not reached for group B, and 8.4 months for group C (95% CI, 5.6–11.1). The median OS was not reached for group A and C, and was 16.2 months for group B. There was no apparent difference in TTF, PFS, or OS between the three groups.

Conclusion
Receiving radiation prior to starting osimertinib for patients with progressing brain metastases did not prolong TTF, PFS, or OS in our series. To minimize the risks of radiation-related toxicity, delaying radiation could be considered for some patients with EGFR-mutant NSCLC with brain metastases who initially respond to osimertinib in the second-line setting.
Adubação orgânica em um plantio de citronela de Java (Cymbopogon winterianus L.), para orientações de manejo em hortas escolares
Authors: Barros Rubens Pessoa de , Barros Glauber Feitosa Xavier de , Gonçalves Henrique Barbosa , Neves Jhonatan David Santos das 
Published: August 2018

Hortas escolares são instrumentos que, a depender do enfoque dado pelo educador, podem ser abordados diferentes conteúdos de forma significativa e contextualizada e promover vivências e resgatar valores. O objetivo deste trabalho foi avaliar o desenvolvimento morfo-fisiológico da espécie Citronela de Java (Cymbopogon winterianus L.), utilizando substrato natural (esterco bovino) em cinco tratamentos com solo + areia lavada + esterco bovino em diferentes concentrações, plantadas em estacas em garrafas tipo PET, para orientações pedagógicas de manejo em hortas escolares para o cultivo e auxílio no combate ao mosquito da dengue (Aedes aegypti). O capim-limão é uma planta da família Poaceae cultivada em quase todos os países tropicais, inclusive no Brasil, tanto para fins industriais como para uso na medicina tradicional. Em virtude da crescente demanda no consumo de plantas medicinais, práticas agronômicas têm sido estudadas para aumentar a sua produtividade e dentre elas, destacam-se a adubação orgânica. Estudos indicam que esta espécie de capim (C. winterianus L.) se propaga através da divisão de touceiras e pode ser cultivada na maioria dos solos sendo mais bem adaptado em solos areno-argilosos, porosos e férteis e em climas tropicais. Os estudos em pesquisa científica e a importância do capim-citronela (C.winterianus L.) têm crescido nos últimos anos principalmente na área de produtos naturais, a grande procura pelo seu óleo essencial, tem levado pesquisadores a fazer plantio deste capim para conhecer o manejo e suas potencialidades medicinais e de repelência contra insetos. A pesquisa foi desenvolvida por alunos do Curso de Licenciatura em Ciências Biológicas e Química. Foram utilizados estacas com raízes de plantas cultivadas na Estufa de experimentos da Uneal – Universidade Estadual de Alagoas – Campus I, o experimento foi delineado em cinco tratamentos e cinco repetições. A pesquisa foi acompanhada a cada semana durante os meses de março a maio de 2009, num total de nove semanas sendo observados e tabulados os dados referentes à altura, número de folhas, de perfilhos por touceira e na coleta das plantas, a biomassa (matéria seca). Foram avaliados tamanhos e quantidade das folhas e seu peso. As análises de variância revelaram que houve diferença significativa nos tratamentos para as variáveis altura, número de folhas e de perfilhos por touceira e de biomassa, a 1 e 5% de probabilidade, as médias de tukey revelaram diferença significativa entre os tratamentos.
Apresentação
Authors: Morato Edwiges Maria , Bentes Anna Christina , Lima Maria Luiza Cunha 
Published: August 2018

É uma alegria para nós trazer a público este número dos Cadernos de Estudos Lingüísticos homenageando Ingedore Grünfeld Villaça Koch, professora, pesquisadora, uma das mais importantes representantes da Lingüística brasileira e que, como ninguém, consegue associar disciplina acadêmica com um olhar transversal sobre a ciência da linguagem e sobre o próprio objeto de estudo.
Hipertexto e intertextualidade
Authors: Xavier Antônio Carlos 
Published: August 2018

This paper aims at reflecting on the presence of intertextuality in hypertexts on-line. Digital hyperlinks are fundamental instruments of reading on the Web. They achieve a complex process of interconnection of hypertexts. Then, intertextuality seems to me the essential characteristic of the hypertexts. They offers to the browsers more access and fast connectivety to some hypertexts on the digital network.
Labirinto de colonialidades e transformações ambientais em terras indígenas em Mato Grosso do Sul
Authors: Guimarães Verônica Maria Bezerra 
Published: August 2018

A partir de análises da história, da sociologia e da antropologia ambiental, o presente trabalho busca compreender os processos de degradação ambiental das terras indígenas no sul do Mato Grosso do Sul, através de um estudo de caso realizado na terra indígena Te’ýkue, localizada no município de Caarapó, Mato Grosso do Sul. Para o estudo de caso, foi realizado trabalho de campo com adoção de técnicas de observação direta, conversas, depoimentos gravados e transcritos, diários de campo, caminhadas, registro de fotografia e participação em encontros de professores indígenas. A população de estudo está caracterizada através de grupos representativos de: idosos, rezadores, professores e lideranças. Os processos de degradação ambiental da terra ou da natureza devido às atividades econômicas hegemônicas que geraram o “desenvolvimento” regional não foram capazes de apagar os saberes sobre a terra, e esta junto com os povos resistem na sua diversidade, muitas vezes “ilhados” face às paisagens e mentalidades monoculturais. Mesmo diante de séculos de colonização com suas atividades econômicas degradadoras, as terras indígenas Guarani-Kaiowá guardam respostas inspiradoras para a ideia de sustentabilidade.
Снижение порога генерации с помощью легирования в лазерах среднего инфракрасного диапазона на основе HgCdTe с квантовыми ямами HgTe
Authors: Дубинов А.А. , Алешкин В.Я. , Морозов С.В. 
Published: August 2018

AbstractThe possibility of significant lowering of the interband lasing threshold in laser structures of the mid-infrared region based on HgCdTe with HgTe quantum wells by doping with donors, which introduce δ layers near quantum wells, is proposed and analyzed. It is shown that at an optimum surface donor concentration in the δ layer of 4 × 10^10 cm^–2 and an operating temperature of >40 K, the lasing threshold at a wavelength of 20 μm can be lowered more than twofold.
El déficit en cuenta corriente, la crisis de divisas y el programa de ajuste económico
Authors: Bouchain Galicia Rafael 
Published: August 2018

El artículo tiene por objeto analizar las causas y desenvolvimiento de la crisis de divisas, que propició la macrodevaluación de diciembre de 1994. La hipótesis central postula que la causa fundamental del quiebre de la estrategia financiera neoliberal se debió al crecimiento explosivo del déficit en cuenta corriente producido durante el salinismo, mismo que fue financiado por masivas entradas de capital vía inversiones en cartera, las cuales reaccionaron de manera volátil ante los acontecimientos violentos de orden político producidos durante 1994.
¿Se puede pensar en una periodización del pensamiento económico?
Authors: Gérard De Bernis 
Published: August 2018

A partir de la constatación de que la historia del pensamiento económico lejos de ser lineal encuentra de periodo en periodo las mismas cuestiones, acumulando experiencias más que conocimientos que conducirían a un saber cada vez más completo, el autor pone a debate tres puntos; a) la evolución del pensamiento económico podría no ser independiente de la alternancia de periodos de estabilidad e inestabilidad; b) el pensamiento evoluciona fuertemente en el curso de cada periodo de inestabilidad, el liberalismo imponiéndose en su inicio para dar lugar progresivamente a una reflexión más constructiva; y, c) ¿puede deducirse que esos periodos de inestabilidad han, hasta ahora, desembocado en un nuevo orden del capitalismo, lo que sería válido de la crisis actual? La cuestión a despejar es, si se puede -sin riesgo de error- afirmar que el pasado se reproducirá invariablemente, y creer entonces en la continuidad o en la eternidad del capitalismo
De la planeación regional del desarrollo a la administración del ajuste en México
Authors: Palomares León Humberto 
Published: August 2018

El trabajo muestra el proceso de abandono y despreocupación de que ha sido objeto la política regional de desarrollo, entendida como la contribución a la integración regional del mercado nacional y a la proyección de las múltiples regiones del país con el exterior. Se ha optado por asumir pasivamente las pautas que son dadas por el modelo imperante actual. Así, los criterios de Estado para la promoción del desarrollo regional están siendo basados sólo en la lógica de la integración hacia el exterior, la recepción de capitales foráneos el fomento a los corredores económicos. Esta reflexión se divide en tres apartados; el primero tiene como meta discutir el carácter estratégico de la planeación del desarrollo regional, el segundo apartado hace un recuento de los cambios en los instrumentos y criterios que han sido utilizados en la planeación, y por último, esquematizar y discutir las bases actuales de la planeación en México.
La flexibilidad laboral como retorno a una concepción liberal de las relaciones de trabajo
Authors: Cos Egea Manrique 
Published: August 2018

El objeto del presente estudio es analizar de qué manera la idea de flexibilidad laboral que informa la conformación del actual Derecho del Trabajo supone un retorno a la concepción liberal de las relaciones laborales. Para ello, el trabajo se estructurará en tres apartados. En el primero de ellos, se recuerda que el principio de libertad igual en el que se basaba el liberalismo decimonónico se tradujo, en el ámbito de las relaciones de trabajo, en la estipulación jurídica de situaciones de explotación entre empresarios burgueses y trabajadores por cuenta ajena.
En el segundo apartado se analiza el surgimiento del Estado Social y de la legislación laboral como instrumento de limitación del poder de dirección del empresario.
En el tercer y último apartado del trabajo constataremos como la flexibilidad laboral, que se presenta por el neoliberalismo como la mejor forma de articular la relación del mercado con el factor trabajo, supone el retorno a una concepción liberal de las relaciones de trabajo en tanto se produce un reforzamiento de los poderes empresariales que introduce la precariedad en el seno de estas relaciones.
Evolución de la inserción de titulados del Grado en Relaciones Laborales y Recursos Humanos de la Universidade da Coruña
Authors: Del Hoyo Ruiz Blanca 
Published: August 2018

La adaptación de los estudios universitarios al Espacio Europeo de Educación Superior (EEES) conlleva el análisis y evaluación de determinados criterios en orden a establecer la validez y adaptación de los nuevos sistemas de aprendizaje al entorno socioeconómico y laboral.
El objetivo del trabajo es analizar los indicadores de inserción laboral que determinen la correspondencia del perfil de egreso esperado respecto del perfil de egreso real de los titulados del Grado.
Se han revisado los datos disponibles sobre egresados entrevistados telefónicamente por la Axencia para a Calidade do Sistema Universitario Galego (ACSUG) (235 entrevistados), a través de cuestionarios por el Observatorio Ocupacional de la Universidade da Coruña (UDC) (288 egresados) y mediante encuestas de satisfacción de los centros en los que se imparte el grado en la UDC (207 titulados).
Los principales resultados se refieren a la percepción de los titulados sobre la formación recibida en la titulación, las características de acceso al empleo y las condiciones del trabajo que desempeñan, siendo la conclusión principal que el perfil de egreso real es acorde al perfil esperado, el cual mantiene su validez respecto del ámbito académico y sociolaboral del entorno.
INFLUENCE OF LEADERSHIP, HAPPINESS, INTERPERSONAL COMMUNICATION TO NORMATIVE COMMITMENT OF PUBLIC JUNIOR HIGH SCHOOL TEACHERS IN KAMPAR REGENCY OF RIAU PROVINCE
Authors: Sispurwanto Yedi , Luddin Muchlis R. , Fitri Rugaiyah 
Published: August 2018

The purpose of this study is to study the influence of leadership, happiness, interpersonal communication to normative commitment of public Junior High School teachers in Kampar Regency of Riau Province. This research uses a quantitative approach with the survey method. The sample of this research is 148 lecturers of civil servant status (PNS) at public Junior High Schools (SMP Negeri) located in Kampar Regency, which is collected from 4 schools, selected based on schools that get the highest National Examination (UN) and National Examination Integrity Index (IIUN) value at 4 sub-districts. The results of this study indicate that (1) leadership has a direct effect on the teacher's normative commitment, (2) happiness directly affects teacher's normative commitment, (3) interpersonal communication has a direct effect on teachers' normative commitment; (4) direct influence toward teacher interpersonal communication (5) happiness directly affects teacher's interpersonal communication, (6) leadership has a direct effect on teacher's happiness, so teacher's normative commitment can be improved if there is a good leadership behavior, happiness in workplace and intimacy in interpersonal communication.
Especially for Kampar Regency of Riau Province, the region which is nicknamed “Riau Province' Veranda of Mecca”, to increase teachers' normative commitment is to facilitate the needs related to facilities and infrastructure, programs, activities that can improve science and practice values ​​to muslim teachers because based on the questionnaire results, the majority of teachers responded to the point that: "I pursue the teaching profession as worship to Allah Subhanahu Wata'ala", with a total score of 707. The statements of the teachers are in line with the Vision of RPJPD (Regional Long Term Development Plan) of Kampar Regency Year 2005-2025, namely: "Kampar Regency a County of Culture, Empowerment, within the Religious Society in the year of 2025", and explained to the explanation of the meaning contained in the vision, in point three, : "All components of Kampar regency are determined to make the religious society, where all aspects of life that are run are always based on religious values, in accordance with Kampar community motto to create Kampar district as “Riau Province' Veranda of Mecca”.
Keywords: leadership, happiness, interpersonal communication, normative commitment
Türkiye Bitkisel ve Hayvansal Üretim Değerlerinin Bölgesel Düzeyde Panel Endeks ile Karşılaştırmalı Analizi
Authors: KARAMAN Süleyman 
Published: August 2018

Bu çalışmada, Türkiye’de
son 12 yılda Düzey bölgelerinin bitkisel üretim ve hayvancılık
faaliyeti üretim değeri performansı ve çiftçilerin tarımsal desteklerden
yararlanma düzeyleri bölgesel düzeyde hesaplanan Panel Veri Endeksi ile
karşılaştırılmaktadır. Türkiye’de tarımsal üretim değeri en fazla TR3 bölgesinde
gerçekleşmiştir. Bu durumun gerçekleşmesinde tarım sektörüne tarımsal politika
araçlarıyla sağlanan desteklerin önemli katkısı olduğu söylenebilir. Çünkü TR3
bölgesi, TRC bölgesinden sonra en fazla tarımsal destek alan bölgedir. TR3
bölgesini, tarımsal üretim değeri açısından sırasıyla, TR7, TR5 ve TRC
bölgeleri izlemektedir. TR9 ve TRC bölgelerinde bitkisel üretim faaliyetinde
kullanılan desteğin üretim değerine yansıması bazı yıllarda belirgin olarak
görülmektedir. TR9 bölgesinde fındık ve
çay, TRC bölgesinde stratejik bir ürün olan pamuk üretildiği için desteklemenin
etkisi doğrudan görülebilmektedir. Hayvancılık faaliyeti yapan çiftçilere
verilen destek 2013 yılına kadar artarak maksimum düzeye ulaşmıştır. Daha
sonraki dönemde desteklemenin azalmasıyla birlikte hayvansal üretim değerinin
de düştüğü görülmektedir. Hayvancılık faaliyeti bölgesel üretim değeri
performanslarına göre TRC bölgesi, son dönemde hayvansal üretim değeri
açısından 2013 yılında 128, 2014 yılında 125 panel endeks değeri ile diğer bölgeler
ve yıllara göre en iyi performansı göstermiştir. Diğer ifadeyle, son yılda
diğer bölgelere göre %25 daha fazla hayvansal üretim değeri gerçekleşmiştir.
TR5, TR6, TRA, TRC ve TR7 bölgelerinde, son dönemde, hayvansal üretim değerinin
panel endeks değeri 100’ün üzerindedir.
ANALISIS ETIKA BISNIS DAN MARKETING NABI MUHAMMAD SAW
Authors: Adzkiya’ Ubbadul 
Published: August 2018

AbstrakEtika bisnis yang dilakukan oleh Nabi Muhammad menjadi menarik untuk dikaji, beliau yang hidup dalam masyarakat Arab bercorak ke-jahiliyyah-an berhasil menerapkan nilai-nilai etika, sebuah kesuksesan luar biasa. Melihat latar belakang kesuksesan Nabi Muhammad dalam berbisnis, sehingga kita patut meneliti, pertama, etika bisnis yang dijalankan Nabi Muhammad. Kedua, serta dalam sektor marketing yang beliau lakukan, karena marketing merupakan ini dari sebuah bisnis. Penulis menggunakan metodologi kualitatif dengan pendekatan sejarah. Penulis mencoba menguak fakta sejarah dibalik kesuksesan Nabi Muhammad dalam berbisnis. Melalui pendekatan sejarah diharapkan dapat memberi gambaran tentang etika bisnis dan marketing yang dipraktekkan oleh Nabi Muhammad. Dengan menggunakan pendekatan sejarah telah membuktikan bahwa; pertama, Nabi Muhammad adalah pedagang sukses, proses panjang yang telah beliau jalani menjadi tuntunan bagi umat manusia untuk meneladani etika bisnis beliau dalam kehidupan sehari-harinya. Pengalamannya sebagai seorang pedagang Nabi Muhammad dapatkan jauh sebelum beliau diutus oleh Allah swt menjadi Nabi dan Rasul. Dan kemudian dari beberapa pengalaman Nabi Muhammad dilegislasikan dalam bentuk sabda setelah beliau diutus. Kedua, Dalam praktek-prakteknya beliau selalu menjunjung tinggi kemanusiaan dan tidak hanya duniawi oriented. Beliau selalu menjaga sifat jujur, ikhlas, profesional, silaturrahim dan murah hati dalam semua aktifitasnya terutama dalam bisnisnya.Keywords: etika, bisnis, dan Muhammad Abstract Business ethics conducted by the Prophet Muhammad became interesting to be studied, he was living in Arab society patterned the jahiliyyah-an successfully applied ethical values. So it can reap a tremendous success. By looking at the background of the Prophet Muhammad's success in business, we should examine, firstly, the business ethics of Prophet Muhammad carried. Secondly, in the marketing sector that he did, because marketing is this form a business. The author uses a qualitative methodology with a historical approach. The author tries to uncover the historical facts behind the success of the Prophet Muhammad in business. Using the historical approach is expected to give an overview of business ethics and marketing practiced by the Prophet Muhammad. Using the historical approach has proved that; first, the Prophet Muhammad is a successful trader, the long process he has undergone as a guide for mankind to emulate his business ethics in his daily life. His experience as a trader of the Prophet Muhammad got long before he was sent by Allah swt to be Prophet and Messenger. And then from some experiences the Prophet Muhammad was legislated in the form of the word after he was sent. Secondly, In his practices he always upholds humanity and is not only worldly oriented. He always maintain the nature of honest, sincere, professional, silaturrahim and generous in all his activities, especially in business.Keyword: etic, business and Muhammad