bluuebunny/crossref_metadata_2025_split huggingface dataset:
An advanced c-MET-amplified NSCLC patient that was treated with crizotinib
Authors: Yilmaz Mesut , Mese Sermin Guven , Cil Ibrahim , Zirtiloglu Alisan 
Published: June 2019

Introduction c-MET is a tyrosine kinase receptor, which is encoded in part by mesenchymal-epidermal transition (MET) exon 14. Mutations in the MET gene can cause increased c-MET signaling and oncogenic stimulation. Although c-MET mutation is rare, it is a targetable driver mutation. Although the guidelines do not recommend routine screening before treatment decision, there are drugs that can be used in patients who have c-MET mutation or amplification. Case report We present a metastatic c-MET-amplified non-small cell lung cancer (NSCLC) patient who was treated with crizotinib. He was not eligible for chemotherapy because of poor performance score; c-MET amplification was investigated after the other common driver mutations were negative. Management and outcome After c-MET amplification was shown, crizotinib 250 mg BID was started. A partial response was achieved with the initiation of crizotinib, and his performance score improved after treatment. Discussion We presented a metastatic c-MET-amplified NSCLC patient, who was not eligible for standard platin doublet chemotherapy, to emphasize the importance of investigating all driver mutations, including c-MET amplification especially in patients who cannot tolerate cytotoxic chemotherapy.
Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials
Authors: Seidu Samuel , Kunutsor Setor K. , Sesso Howard D. , Gaziano J. M. , Buring J. E. , Roncaglioni Maria Carla , Khunti Kamlesh 
Published: June 2019

Abstract
Background
The clinical benefit of aspirin for the primary prevention of cardiovascular disease (CVD) in diabetes remains uncertain. To evaluate the efficacy and safety of aspirin for the primary prevention of cardiovascular outcomes and all-cause mortality events in people with diabetes, we conducted an updated meta-analysis of published randomised controlled trials (RCTs) and a pooled analysis of individual participant data (IPD) from three trials.

Methods
Randomised controlled trials of aspirin compared with placebo (or no treatment) in participants with diabetes with no known CVD were identified from MEDLINE, Embase, Cochrane Library, and manual search of bibliographies to January 2019. Relative risks with 95% confidence intervals were used as the summary measures of associations.

Results
We included 12 RCTs based on 34,227 participants with a median treatment duration of 5.0 years. Comparing aspirin use with no aspirin, there was a significant reduction in risk of major adverse cardiovascular events (MACE)0.89 (0.83–0.95), with a number needed to treat (NNT)of 95 (95% CI 61 to 208) to prevent one MACE over 5 years average follow-up. Evidence was lacking of heterogeneity and publication bias among contributing trials for MACE. Aspirin use had no effect on other endpoints including all-cause mortality; however, there was a significant reduction in stroke for aspirin dosage ≤ 100 mg/day 0.75 (0.59–0.95). There were no significant effects of aspirin use on major bleeding and other bleeding events, though some of the estimates were imprecise. Pooled IPD from the three trials (2306 participants) showed no significant evidence of an effect of aspirin on any of the outcomes evaluated; however, aspirin reduced the risk of MACE in non-smokers 0.70 (0.51–0.96) with a NNT of 33 (95% CI 20 to 246) to prevent one MACE.

Conclusions
Aspirin has potential benefits in cardiovascular primary prevention in diabetes. The use of low dose aspirin may need to be individualised and based on each individual’s baseline CVD and bleeding risk.
Systematic review registration PROSPERO: CRD42019122326
Pediatric Central Nervous System Demyelinating Diseases
Authors: Chitnis Tanuja 
Published: June 2019

ABSTRACT

PURPOSE OF REVIEW
This article provides an up-to-date summary of the categories, diagnosis, and management of pediatric demyelinating disorders.

Recent Findings
Understanding of the diverse spectrum of pediatric demyelinating disorders, including monophasic and multiphasic forms, has improved. Pediatric multiple sclerosis (MS) is the most common demyelinating disorder in children, and recent genetic and environmental risk research has clarified that pediatric MS is on the same continuum of disease as adult MS. Recent advances in the treatment of pediatric MS include clinical trials leading to regulatory agency–approved treatments. The identification of myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies in children has been a major advance, allowing for appropriate treatment and management of these syndromes.

Summary
Antibody testing is now helping to define subtypes of pediatric demyelinating disorders, including myelin oligodendrocyte glycoprotein–seropositive and aquaporin-4–seropositive cases that are distinct from pediatric MS. Treatments for pediatric MS are being evaluated in clinical trials.
Management of Multiple Sclerosis Relapses
Authors: Repovic Pavle 
Published: June 2019

ABSTRACT

PURPOSE OF REVIEW
This article provides an overview of the clinical and pathologic features of multiple sclerosis (MS) relapses and reviews evidence-based approaches to their treatment.

RECENT FINDINGS
Despite the increasing number and potency of MS treatments, relapses remain one of the more unpredictable and disconcerting disease aspects for many patients with MS, making their accurate recognition and treatment an essential component of good clinical care. The expanding range of relapse treatments now includes oral corticosteroids, comparable in efficacy to IV methylprednisolone at a fraction of the cost. While this development improves access to prompt treatment, it also underscores the importance of recognizing mimics of MS relapses to reduce corticosteroid overuse and its attendant risks.

SUMMARY
Like MS itself, MS relapse remains primarily a clinical diagnosis. The treatment options for MS relapse include corticosteroids, adrenocorticotropic hormone (ACTH), plasma exchange, and rehabilitation, used singly or sequentially, with the goal of limiting the duration and impact of associated disability. Even when treated promptly and effectively, clinical or subclinical sequelae of MS relapses frequently remain.
Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis
Authors: Bastidas-Ponce Aimée , Tritschler Sophie , Dony Leander , Scheibner Katharina , Tarquis-Medina Marta , Salinno Ciro , Schirge Silvia , Burtscher Ingo , Böttcher Anika , Theis Fabian J. , Lickert Heiko , Bakhti Mostafa 
Published: June 2019

ABSTRACT
Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in vivo will provide valuable insights into how the islets of Langerhans are generated. Currently, it is ill defined how endocrine progenitors segregate into different endocrine subtypes during development. Here, we generated a novel neurogenin 3 (Ngn3)-Venus fusion (NVF) reporter mouse line, that closely mirrors the transient endogenous Ngn3 protein expression. To define an in vivo roadmap of endocrinogenesis, we performed single cell RNA sequencing of 36,351 pancreatic epithelial and NVF+ cells during secondary transition. This allowed Ngn3low endocrine progenitors, Ngn3high endocrine precursors, Fev+ endocrine lineage and hormone+ endocrine subtypes to be distinguished and time-resolved, and molecular programs during the step-wise lineage restriction steps to be delineated. Strikingly, we identified 58 novel signature genes that show the same transient expression dynamics as Ngn3 in the 7260 profiled Ngn3-expressing cells. The differential expression of these genes in endocrine precursors associated with their cell-fate allocation towards distinct endocrine cell types. Thus, the generation of an accurately regulated NVF reporter allowed us to temporally resolve endocrine lineage development to provide a fine-grained single cell molecular profile of endocrinogenesis in vivo.
Registry stakeholders
Authors: Lübbeke Anne , Carr Andrew J , Hoffmeyer Pierre 
Published: June 2019

Clinical registries are health information systems, which have the mission to collect multidimensional real-world data over the long term, and to generate relevant information and actionable knowledge to address current serious healthcare problems. This article provides an overview of clinical registries and their relevant stakeholders, focussing on registry structure and functioning, each stakeholder’s specific interests, and on their involvement in the registry’s information input and output. Stakeholders of clinical registries include the patients, healthcare providers (professionals and facilities), financiers (government, insurance companies), public health and regulatory agencies, industry, the research community and the media. The article discusses (1) challenges in stakeholder interaction and how to strengthen the central role of the patient, (2) the importance of adding cost reporting to enable informed value choices, and (3) the need for proof of clinical and public health utility of registries. In its best form, a registry is a mission-driven, independent stakeholder–registry team collaboration that enables rapid, transparent and open-access knowledge generation and dissemination.Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180077
Resection of heterotopic ossification around the hip after trauma
Authors: de l’Escalopier Nicolas , Salga Marjorie , Gatin Laure , Genêt François , Denormandie Philippe 
Published: June 2019

Traumatic neurological lesions may lead to development of heterotopic ossification. These cases are classified as ‘neurogenic heterotopic ossifications’ (NHOs). The associated neurological lesions can be caused by cranial trauma or spinal cord injury and may sometimes include a local trauma. NHOs that form around the hip joints are of particular interest because they often cause the patient to avoid the sitting position or the resumption of walking. Whilst NHO can involve the knee, shoulder and elbow joints, hip-involving NHOs are more numerous, and sometimes develop in close contact with vascular or neurological structures. Multi-disciplinary clinical examination is fundamental to evaluate patients for surgical intervention and to define the objectives of the surgery. The best investigation to define an NHO mass is a computerized tomography (CT) scan. Resection is performed to liberate a fused joint to provide functionality, and this need not be exhaustive if it is not necessary to increase the range of motion. While recurrence does occur post-surgery, a partial resection does not pose a greater risk of recurrence and there are no adjuvant treatments available to reduce this risk. The greatest risks associated with NHO surgical resection are infection and haematoma; these risks are very high and must be considered when evaluating patients for surgery. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180098
Lean Work and Gender Inequalities: Manufacturing Consent at a Multinational Car Plant in Provincial Russia
Authors: Krzywdzinski Martin , Lechowski Grzegorz , Mählmeyer Valentina 
Published: June 2019

How do local labour market structures, in tandem with workforce dispositions and attitudes, influence the way multinational companies localise their standardised work and production systems? This article investigates the conflict-ridden factory regime of a lean automotive plant in provincial Russia at which the management was able to secure a relatively high level of consent among its female workers but not among male workers. In order to explain this gendered pattern of worker consent, the plant-internal gender division of labour and two societal factors proved crucial: the gendered segmentation of the local labour market and the workers’ cultural dispositions. At the same time, the analysis points to the transformative effect that the company’s work and production system had on the local labour regime. The case study relies on a combination of quantitative survey data and qualitative interviews. It emphasises the need to reconnect the analysis of branch-plant factory regimes to a nuanced understanding of their embeddedness within local labour markets – also in the case of highly standardised work and production systems.
KEY WORDS: labour control regime; labour process; labour market; lean production; gender relations
Safety Interventions and Liquid Laundry Detergent Packet Exposures
Authors: Gaw Christopher E. , Spiller Henry A. , Casavant Marcel J. , Chounthirath Thitphalak , Smith Gary A. 
Published: June 2019

OBJECTIVES:To investigate exposures to liquid laundry detergent packets among children &lt;6 years old in the United States and to evaluate the impact of the American Society for Testing and Materials voluntary product safety standard.METHODS:Data from the National Poison Data System involving exposures to liquid laundry detergent packets from 2012 to 2017 were analyzed.RESULTS:From January 2012 to December 2017, there were 72 947 single and polysubstance exposures to liquid laundry detergent packets. Most exposures (91.7%) were documented among children &lt;6 years old. The annual number and rate of exposures for children &lt;6 years old increased by 110.4% and 111.9%, respectively, from 2012 to 2015. From 2015 to 2017, the number and rate of exposures in this age group decreased by 18.0%. Among individuals ≥6 years old, the annual number and rate of exposures increased by 292.7% and 276.7%, respectively, from 2012 to 2017. Annual hospital admissions among children &lt;6 years old increased by 63.4% from 2012 to 2015 and declined by 55.5% from 2015 to 2017. Serious outcomes among children &lt;6 years old increased by 78.5% from 2012 to 2015 and declined by 32.9% from 2015 to 2017.CONCLUSIONS:The number, rate, and severity of liquid laundry detergent packet exposures have decreased modestly in recent years among children &lt;6 years old, likely attributable, in part, to the voluntary product safety standard and public awareness efforts. Exposures among older children and adults are increasing. Opportunities exist to strengthen the current product safety standard to further reduce exposures.
An Investigation of Students’ Interactivity in the Classroom and within Learning Management System to Improve Learning Outcomes / Istraživanje o interaktivnosti studenata u učionici i interaktivnosti studenata u sustavu za upravljanje učenjem s ciljem pob
Authors: Oluwajana Dokun , Nat Muesser , Fadiya Samson 
Published: June 2019

AbstractThis study developed a conceptual framework on interactivity in the classroom, interactivity within Learning Management System (LMS), student engagement and satisfaction as four key underlying factors that will enhance learning outcomes. Furthermore, the study investigates interactivity in the classroom and within LMS with respect to student engagement, student satisfaction and its impact on educational learning outcome. Data were collected using a structured questionnaire. Based on the survey data from 178 respondents, SEM was employed to assess the model. We also experimentally assessed the relationship between the variables of the model by employing SEM method. However, the findings indicate that high interactivity in the classroom has a positive influence on student engagement and student satisfaction towards improving student learning outcomes. Also, the study shed more light on the moderate level of interactivity within the LMS by the student and pointed out which areas should be improved. The result further indicates the importance of interactivity in the educational environment and points to the need for more interactivity in the learning space of educational institutions.Key words: classroom; interactivity; learning outcomes; Learning Management System; university.---SažetakU ovom istraživanju izrađen je konceptualni okvir o interaktivnosti studenata u učionici, interaktivnosti studenata u sustavu za upravljanje učenjem, sudjelovanju studenata u nastavi i njihovu zadovoljstvu nastavom. To su bila četiri ključna čimbenika koja vode boljim ishodima učenja. Nadalje, istraživanjem se ispitala i interaktivnost u učionici i interaktivnost u sustavu za upravljanje učenjem s obzirom na sudjelovanje studenata u nastavi, njihovo zadovoljstvo nastavom i utjecaju koji sve navedeno ima na obrazovne ishode. Podaci su prikupljeni s pomoću strukturiranog upitnika i utemeljeni na obradi podataka dobivenih od 178 ispitanika. Za procjenu modela primijenjena je SEM metoda. Također smo eksperimentalno procijenili i vezu među varijablama unutar modela s pomoću SEM metode. Međutim, rezultati pokazuju da velika količina interaktivnosti u učionici ima pozitivan utjecaj na sudjelovanje studenata u nastavi i na njihovo zadovoljstvo, a da to sve vodi boljim ishodima učenja. Istraživanje je također razjasnilo i umjerenu interaktivnost među studentima u sustavu za upravljanje učenjem te istaknulo područja koja je potrebno doraditi. Taj rezultat pokazuje i važnost interaktivnosti u obrazovnom okruženju i ističe potrebu za većim stupnjem interaktivnosti u okruženju za učenje u obrazovnim institucijama. Ključne riječi: učionica, interaktivnost, ishodi učenja, sustav za upravljanje učenjem, sveučilište
A Critical Analysis of the PISA Mathematics Tasks/Kritički prikaz matematičkih zadataka PISA testa
Authors: Marković Olivera , Pikula Milenko , Zubac Marina 
Published: June 2019

AbstractIn this paper, the authors deal with a critical analysis of some of the problems associated with PISA testing in mathematics. First of all, the social, economic and political circumstances of the launch of the PISA project are pointed out. This is followed by an analysis of what the authors consider as very important concepts for understanding PISA philosophy, such as applicable knowledge and problem solving in a real-life situation. We compared two different ways of defining these concepts and showed what the consequences of learning and teaching mathematics are in each of the cases. The authors present the results of the research that was conducted with mathematics teachers, as well as teachers of other subjects. The research dealt with the determination of the importance and role of the mathematical tasks of the PISA test for students’ further mathematical education. The results of the research have shown that there is a significant statistical difference between the assessment provided by the teachers who do and those who do not teach mathematics. The paper also analysed some specific tasks that the students were solving in PISA tests. The authors point out some deficiencies and inaccuracies observed in the mathematics tasks on PISA tests, as well as the weaknesses of PISA testing itself.Key words: functional knowledge; mathematical literacy; real-life situation; teaching mathematics. --- Sažetak U ovom radu autori se bave kritičkom analizom nekih problema vezanih uz PISA testiranje iz matematike. Prije svega ukazano je na društvene, ekonomske i političke okolnosti pokretanja PISA projekta. Zatim su analizirani, po mišljenju autora, vrlo važni pojmovi za razumijevanje PISA filozofije, a to su primjenjivo znanje i rješavanje problema u stvarnoj životnoj situaciji. Usporedili smo dva različita načina definiranja ovih pojmova i pokazali koje su posljedice po učenje i nastavu matematike u oba slučaja. Izložili smo rezultate istraživanja koje smo proveli s nastavnicima matematike, ali i nastavnicima drugih predmeta. Istraživanje se odnosilo na utvrđivanje značaja i uloge matematičkih zadataka PISA testa za daljnje matematičko obrazovanje učenika. Rezultati istraživanja su pokazali da postoji statistički značajna razlika između procjena nastavnika koji predaju i nastavnika koji ne predaju matematiku. U radu smo analizirali i konkretne zadatke koje su učenici rješavali na PISA testiranju. Ukazali smo na izvjesne nedostatke i nepreciznosti matematičkih zadataka PISA testova, kao i na slabosti samog PISA testiranja. Ključne riječi: funkcionalno znanje; matematička pismenost; nastava matematike; stvarna životna situacija.
Classroom Quality in Final Grades of Lower Secondary Education: Demographic Differences and Relationship with Target Learning Orientations / Kvaliteta nastave u završnim razredima nižeg sekundarnog obrazovanja: demografske razlike i povezanost s ciljnim
Authors: Đuranović Marina 
Published: June 2019

AbstractThe goal of the research was to examine the features of classroom quality concerning gender, grade and general academic record, and the connection with target orientations in learning among students in the final grades of primary school (lower secondary education, ISED level 2). Seventh- and eighth-grade students (N=512) from Split-Dalmatia County and the City of Zagreb participated in the research. The questionnaire was used to collect demographic data (gender, grade and final academic record). For data regarding self-assessment of classroom quality, we used the Student Perception of Classroom Quality Questionnaire – SPOCQ. Data about target orientations was collected through the Components of Self-Regulated Learning Questionnaire – CRSL. The given results show that students, regardless of age, gender or general academic record, mostly perceive classes as average on all quality dimensions and are inclined to all three learning orientations somewhat above average. Furthermore, aspects of classroom quality were shown as the most significant predictors of all individual target orientations in learning, considering the fact that almost one third of the learning orientation is explained with classroom quality, but very little is directed to performance or avoiding effort. Key words: classroom quality; primary school; students; target orientations. ---SažetakCilj istraživanja bio je ispitati obilježja kvalitete nastave s obzirom na spol, razred i opći školski uspjeh te povezanost s ciljnim orijentacijama u učenju kod učenika završnih razreda osnovne škole (niže sekundarno obrazovanje, ISCED razina 2). U istraživanju su sudjelovali učenici sedmih i osmih razreda (N = 512) osnovnih škola Splitsko-dalmatinske županije i Grada Zagreba. Upitnikom su prikupljeni demografski podatci (spol, razred i završni uspjeh), a za podatke o samoprocjeni kvalitete nastave koristio se Upitnik učeničke percepcije kvalitete nastave (engl. Student perception of classroom quality - SPOCQ). Podaci o ciljnim orijentacijama u učenju prikupljeni su Upitnikom ciljnih orijentacija (Components of Self-regulated Learning – CSRL). Dobiveni rezultati ukazuju na to da učenici, bez obzira na dob, spol i opći uspjeh, uglavnom percipiraju nastavu prosječnom prema svim dimenzija kvalitete te da su blago iznadprosječno skloni svim trima orijentacijama učenja. Nadalje, kao najznačajniji prediktori sve pojedine ciljne orijentacije u učenju pokazali su se aspekti kvalitete nastave, s time da se kvalitetom nastave objašnjava gotovo trećina orijentacije na učenje, ali veoma malo orijentacije usmjerene na izvedbu i izbjegavanje truda. Ključne riječi: ciljne orijentacije; kvaliteta nastave; osnovna škola; učenici