bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient‐Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa
Authors: Chernyshov P.V. , Zouboulis C.C. , Tomas‐Aragones L. , Jemec G.B. , Svensson A. , Manolache L. , Tzellos T. , Sampogna F. , Pustisek N. , van der Zee H.H. , Marron S.E. , Spillekom‐van Koulil S. , Bewley A. , Linder D. , Abeni D. , Szepietowski J.C. , Augustin M. , Finlay A.Y. 
Published: May 2019

AbstractThis paper is organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Quality of Life (QoL) and Patient‐Oriented Outcomes and the EADV TF on acne, rosacea and hidradenitis suppurativa (ARHS). The purpose of this paper was to present current knowledge about QoL assessment in HS, including data on HS‐specific health‐related (HR) QoL instruments and HRQoL changes in clinical trials, and to make practical recommendations concerning the assessment of QoL in people with HS. HS results in significant quimp that is higher than in most other chronic skin diseases. HS impact in published studies was assessed predominantly (84% of studies) by the Dermatology Life Quality Index (DLQI). There is a lack of high‐quality clinical trials in HS patients where HRQoL instruments have been used as outcome measures. One double‐blind randomized placebo‐controlled trial on infliximab with low number of participants reported significantly better HRQoL improvement in the treatment group than in the placebo group. Well‐designed clinical studies in HS patients to compare different treatment methods, including surgical methods and assessing long‐term effects, are needed. Because of lack of sufficient validation, the Task Forces are not at present able to recommend existing HS‐specific HRQoL instruments for use in clinical studies. The EADV TFs recommend the dermatology‐specific DLQI questionnaire for use in HS patients. The EADV TFs encourage the further development, validation and use of other HS‐specific, dermatology‐specific and generic instruments but such use should be based on the principles presented in the previous publications of the EADV TF on QoL and Patient‐Oriented Outcomes.
Unprecedented widespread occurrence of Pink Salmon Oncorhynchus gorbuscha in Ireland in 2017
Authors: Millane Michael , Walsh Laura , Roche William K. , Gargan Patrick G. 
Published: May 2019

AbstractThe occurrence of non‐native pink salmon Oncorhynchus gorbuscha in multiple river systems in Ireland in 2017 was unprecedented and reflected similar concurrent events observed in other countries in the North Atlantic region. Thirty‐six fish were captured in a total of 11 river systems located in the south‐west, west and north‐west of Ireland in the period June to September 2017. The biological characteristics of sampled specimens are described and the potential for establishment in Ireland are considered.
REVISITING BOOKBUILDING VERSUS AUCTION IPOS: A PERSPECTIVE OF INFORMATIONALLY EFFICIENT PRICES IN THE AFTERMARKET
Authors: Shim Hyeongsop , Lee Junyoup , Yi Ha‐Chin 
Published: May 2019

AbstractWe compare price efficiency between auction and bookbuilding initial public offerings (IPOs). Our empirical results fail to support the prevailing conjecture that bookbuilding IPOs are more price efficient than auction IPOs. We find statistical insignificance between two IPO samples or weak evidence for the opposite hypothesis. We add to the evidence that auctions yield aftermarket price efficiency equal to that of bookbuilding or are statistically indifferent when measured by market microstructure and Center for Research in Security Prices (CRSP) data. We also examine whether underlying price efficiency forces reflect the relative presence of informed institutional and retail investors, aftermarket price support, and divergence of investor expectations.
Mass modeling of kinnow mandarin based on some physical attributes
Authors: Mahawar Manoj K. , Bibwe Bhushan , Jalgaonkar Kirti , Ghodki Bhupendra M. 
Published: May 2019

AbstractThe correlation between the physical properties of fruits such as their dimensions, projected areas, volume, and mass may assist in predicting fruit quality along with the development of post‐harvest machinery. Thus, the present study aims to predict the mass of kinnow mandarin (Citrus reticulata L.) fruit as a function of its axial dimensions, projected areas, and volume using linear and nonlinear mathematical models (quadratic, power, and s‐curve). Further, the mass models were presented under three different classifications: dimension based, projected area based, and volume based. The effect of size grading was also evaluated and compared with the data of ungraded fruits. Results showed that mass modeling based on dimensions and volume of ungraded fruits was more appropriate compared to individual grades. The quadratic model based on geometric mean diameter (R2 = 0.956) and ellipsoid volume (R2 = 0.955) are recommended for predicting the mass of ungraded fruits with maximal accuracy.Practical applicationMass based fruit grading is one of the important aspects of packaging as it not only reduces the wastage of handling and transportation resources by optimizing packaging formations but also enhances the marketability of commodity. Consumers generally prefer the fruits of uniform size, weight, and shape. Grading of horticultural produce is usually based on its appearance, size, and weight. The automatic fruit grading techniques generally use mass as a grading parameter due to its accuracy and effectiveness of the operation. The available kinnow grading systems primarily grade the fruits based on their dimensional attributes. Hence, the study was aimed at mass modeling of kinnow mandarin based on the selected engineering attributes such that results might be helpful to develop an accurate automatic grading system for grading based on the combined approach of size and mass. This study provides information about relationships between fruit mass and axial dimensions, projected areas, and volume, which are useful for the development of mass, and size based kinnow grading systems.
Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction
Authors: Zhang Cheng , Ge Shuang , Wang Jun , Jing Xiaotong , Li Hailing , Mei Shuyu , Zhang Juan , Liang Ke , Xu Hui , Zhang Xiaoying , Zhang Cuijuan 
Published: May 2019

AbstractBackground and AimDNA hypermethylation has emerged as a novel molecular biomarker for the diagnosis and prognosis prediction of many cancers. We aimed to identify clinically useful biomarkers regulated by DNA methylation in hepatocellular carcinoma (HCC).MethodsGenome‐wide methylation analysis in HCCs and paired noncancerous tissues was performed using an Illumina Infinium HumanMethylation 450K BeadChip array. Methylation‐specific polymerase chain reaction and pyrosequencing were used to validate the methylation status of selected genes in 100 paired HCCs and noncancerous samples.ResultsA total of 97 027 (20.0%) out of 485 577 CpG sites significantly were differed between HCC and noncancerous tissues. Among all the significant CpG sites, 48.8% are hypermethylated and 51.2% are hypomethylated in HCCs. Multiple signaling pathways (AMP‐activated protein kinase, estrogen, and adipocytokine) involved in gene methylation were identified in HCC. FES was selected for further analysis based on its high level of methylation confirmed by polymerase chain reaction and pyrosequencing. The result showed that FES hypermethylation was correlated with tumor size (0.001), serum alpha fetoprotein (0.023), and tumor differentiation (0.006). FES protein was significantly downregulated in 51/100 (51%) HCCs, and 94.12% (48/51) of them were due to promoter hypermethylation. Both FES hypermethylation and protein downregulation were associated with the progression‐free survival and overall survival of HCC patients. Overexpressed and knockdown of FES confirmed its inhibitory effect on the proliferation and migration of HCC cells.ConclusionsWe identified many new differentially methylated CpGs in HCCs and demonstrate that FES functions as a tumor suppressor gene in HCC and its methylation status could be used as an indicator for prognosis of HCC.
Integrating Oral Health Curricula into Midwifery Graduate Programs: Results of a US Survey
Authors: Haber Judith , Dolce Maria C. , Hartnett Erin , Savageau Judith A. , Altman Susan , Lange‐Kessler Julia , Silk Hugh 
Published: May 2019

IntroductionMidwives are a significant segment of the US maternal and primary health care workforce and play a pivotal role in addressing women's oral health care needs during pregnancy and throughout their life span. The purpose of this research was to assess oral health curricular integration in midwifery programs and examine factors that influence integration and satisfaction with graduates’ level of oral health competence.MethodsA cross‐sectional, national survey of midwifery programs was conducted using an electronically distributed 19‐item, self‐administered questionnaire completed by the Directors of Midwifery Education. Data analysis included univariate and bivariate statistics.ResultsAll of the responding midwifery programs (N = 33) were educating their graduates about oral health; however, less than a quarter (22.6%) of program directors were satisfied with their graduates’ competency. Significant factors promoting integration were routine teaching by a dental professional and a formal relationship with a dental school, dental residency, or dental hygiene program. Programs with 4 or more hours of oral health curriculum were more likely to have a faculty oral health champion, use simulation in evaluation of their learners, and include interprofessional oral health education.DiscussionWith adequate oral health education, midwives are ideally positioned to integrate oral health in pregnancy care as well as well woman care throughout the life span, thereby expanding access to oral health care.
It takes two! Exploring sex differences in parenting neurobiology and behaviour
Authors: Rajhans Purva , Goin‐Kochel Robin P. , Strathearn Lane , Kim Sohye 
Published: May 2019

AbstractParents lay the foundation for their children's socio‐emotional experiences by sensitively responding to their needs. The hormonal and neurobiological changes that occur during the transition to parenthood importantly contribute to the parents’ caregiving behaviour toward their children. Much research has emphasised the relationship between the mother, who is most often the primary caregiver, and her infant, with less focus on the role of fathers in child development. However, recent accounts have suggested that fathers also play an important role in promoting the health, development and psychosocial wellbeing of their children. Evidence from the behavioural literature has indicated that there are significant differences between typical mother‐infant versus father‐infant interactions. The current review aims to outline differences between maternal and paternal caregiving by discussing the differences in their biological mechanisms. First, we focus on the different hormones that are correlated with sensitive parenting behaviours in mothers and fathers. Next, we discuss the differences between neural bases of motherhood and fatherhood. Lastly, we discuss ways in which parental hormones, parental brain and parental exposure to infant cues interact to shape parental caregiving behaviour. In summary, this review highlights the distinct but complementary nature of maternal and paternal caregiving.
Characterisation and origins of melanin‐concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long‐Evans rat
Authors: Costa Helder C. , Da‐Silva Joelcimar M. , Diniz Giovanne B. , Motta‐Teixeira Livia C. , Da‐Silva Renata J. , Battagello Daniella S. , Sita Luciane V. , de‐Moraes Machado Carla , Horta‐Júnior José A. C. , Bittencourt Jackson C. 
Published: May 2019

AbstractAlthough the melanin‐concentrating hormone (MCH) and its coding mRNA are predominantly found in the tuberal hypothalamus, there is detectable synthesis of MCH in the preoptic hypothalamus exclusively in lactating dams, suggesting a participation of MCH in the alterations that take place after parturition. Also implicated in the dam physiology is oxytocin, a neurohormone released from the posterior pituitary that is necessary for milk ejection. Because the projection fields from oxytocin‐immunoreactive (‐IR) neurones and the mediobasal preoptic hypothalamus overlap and MCH‐IR neurones are found in proximity to oxytocin neurones, we investigated the spatial relationship between MCH and oxytocin fibres. Accordingly, we employed multiple immunohistochemistry labelling for MCH and oxytocin for light and electron microscopy techniques, in addition to i.v. tracer injection combined with in situ hybridisation to identify MCH neurones that project to neurosecretory areas. As described for other strains, lactating Long‐Evans dams also display immunoreactivity for MCH in the preoptic hypothalamus on days 12 and 19 of lactation. The appearance of these neurones is contemporaneous with an increase in MCH‐IR fibres in both the internal layer of the median eminence and the posterior pituitary. In both regions, MCH‐ and oxytocin‐IR fibres were found in great proximity, although there was no evidence for synaptic interaction between these two populations at the ultrastructural level. The tracer injection revealed that only mediobasal preoptic MCH neurones project to the posterior pituitary, suggesting a neuroendocrine‐modulatory role for this population. When taken together, the results obtained in the present study indicate that neuroplasticity events at the mediobasal preoptic hypothalamus that occur during late lactation may be part of a neuroendocrinology control loop involving both MCH and oxytocin.
Associations between tooth wear and dental sleep disorders: A narrative overview
Authors: Wetselaar Peter , Manfredini Daniele , Ahlberg Jari , Johansson Anders , Aarab Ghizlane , Papagianni Chryssa E. , Reyes Sevilla Marisol , Koutris Michail , Lobbezoo Frank 
Published: May 2019

AbstractObjectivesTooth wear is a common finding in adult patients with dental sleep disorders. The aim of this paper was to review the literature on the possible associations between tooth wear and the following dental sleep disorders: sleep‐related oro‐facial pain, oral moistening disorders, gastroesophageal reflux disease (GERD), obstructive sleep apnoea syndrome (OSAS) and sleep bruxism.MethodsA PubMed search was performed on 1 June 2018 using MeSH terms in the following query: Tooth Wear AND (Facial Pain OR Temporomandibular Joint Disorders OR Xerostomia OR Sialorrhea OR Gastroesophageal Reflux OR Sleep Apnea Syndrome OR Sleep Bruxism).ResultsThe query yielded 706 reports on tooth wear and the mentioned dental sleep disorders. Several associations between tooth wear and the dental sleep disorders were suggested in the literature. It could be concluded that: (a) tooth wear is associated with dental pain and/or hypersensitivity; (b) oral dryness is associated with tooth wear, oro‐facial pain and sleep bruxism; (c) GERD is associated with tooth wear, oro‐facial pain, oral dryness, OSAS and sleep bruxism; (d) OSAS is associated with oral dryness, GERD and sleep bruxism; and (e) sleep bruxism is associated with tooth wear.ConclusionsTooth wear is associated with the dental sleep disorders oro‐facial pain, oral dryness, GERD and sleep bruxism. The dental sleep disorders are interlinked with each other, which leads to indirect associations as well, and makes the consequences of each single condition difficult to disentangle. Knowledge of these associations is clinically relevant, but more research is needed to confirm their validity.
Recession‐proof skills, cities, and resilience in economic downturns
Authors: Weinstein Amanda , Patrick Carlianne 
Published: May 2019

AbstractWe provide evidence, by combining Occupational Information Network (O*NET) data with monthly Current Population Survey data from 1990 to 2015, that occupations characterized by high cognitive and people skill requirements are less sensitive to recessions, conditional on educational attainment, industry, and individual characteristics. These results are driven by urban areas, particularly noncollege educated people in urban areas, and vary with city size. Finally, we provide the first evidence that metropolitan areas’ recovery from economic downturns depends upon initial skill composition of occupations in the area.
Pediatric Farm Injuries Presenting to United States Emergency Departments, 2001‐2014
Authors: Zagel Alicia L. , Kreykes Nathaniel S. , Handt Erica A. 
Published: May 2019

AbstractPurposeWhile it is well‐known that injuries are a common cause of morbidity among children, limited information is available on injuries that occur in agricultural settings. This study characterizes pediatric farm injuries that present to United States emergency departments and compares them to injuries that occur in the normal course of childhood, at homes and residences.MethodsA retrospective analysis of the National Electronic Injury Surveillance System‐All Injury Program, 2001‐2014, compared injuries occurring on farms to those at homes in youth ages <20 years. Linear regression models assessed injuries over the time period among demographic subgroups.FindingsBetween 2001 and 2014, there were an estimated 279,279 injuries that occurred on farms in youth <20 years. Farm injuries most commonly occurred among youth ages from 15 to 19 years (44%, 95% confidence interval [CI]: 39%‐49%), whereas home injuries were often among children <5 years (42%, 95% CI: 39%‐45%). After adjusting for confounders, farm injuries were 60 times more likely to be caused by machinery and 4 times more likely to result in hospitalization than home injuries. Overall, the number of farm injuries decreased by 44% between 2001 and 2014.ConclusionsCharacteristics of youth farm injuries are much different from injuries occurring at homes. Although the overall number of farm injuries among youth has decreased substantially over time, injury prevention initiatives targeted toward these particular injuries are important to continue due to the significant morbidity of these injuries.
Worldwide long‐distance dispersal favored by epizoochorous traits in the biogeographic history of Omphalodeae (Boraginaceae)
Authors: Otero Ana , Jiménez‐Mejías Pedro , Valcárcel Virginia , Vargas Pablo 
Published: May 2019

AbstractBiogeographic dispersal is supported by numerous phylogenetic results. In particular, transoceanic dispersal, rather than vicariance, is suggested for some plant lineages despite current long distances between America and Europe. However, few studies on the biogeographic history of plants have also studied the role of diaspore syndromes in long‐distance dispersal (LDD). Species of the tribe Omphalodeae (Boraginaceae) offer a suitable study system because the species have a wide variety of diaspore traits related to LDD and different lineages conform to patched worldwide distributions on three distant continents (Europe, America and New Zealand). Our aim is to reconstruct the biogeographical history of the Omphalodeae and to investigate the role of diaspore traits favoring LDD and current geographic distributions. To this end, a time‐calibrated phylogeny with 29 of 32 species described for Omphalodeae was reconstructed using biogeographical analyses (BioGeoBEARS, Lagrange) and models (DEC and DIVA) under different scenarios of land connectivity. Character‐state reconstruction (SIMMAP) and diversification rate estimations of the main lineages were also performed. The main result is that epizoochorous traits have been the ancestral state of LDD syndromes in most clades. An early diversification age of the tribe is inferred in the Western Mediterranean during late Oligocene. Colonization of the New World by Omphalodeae, followed by fast lineage differentiation, took place sometime in the Oligocene‐Miocene boundary, as already inferred for other angiosperm genera. In contrast, colonization of remote islands (New Zealand, Juan Fernández) occurred considerably later in the Miocene‐Pliocene boundary.
Extinct genus Lagokarpos reveals a biogeographic connection between Tibet and other regions in the Northern Hemisphere during the Paleogene
Authors: Tang He , Liu Jia , Wu Fei‐Xiang , Spicer Teresa , Spicer Robert A. , Deng Wei‐Yu‐Dong , Xu Cong‐Li , Zhao Fan , Huang Jian , Li Shu‐Feng , Su Tao , Zhou Zhe‐Kun 
Published: May 2019

AbstractThe biodiversity history on the Qinghai–Tibetan Plateau (QTP) has remained unclear for a long time. Recent paleobotanical investigations provide opportunities for revealing the phytogeographic history on the QTP in deep time and for testing phylogeographic hypotheses. Lagokarpos is an extinct genus with unknown modern affinities. It is easily distinguished by its fruits, which have two long wings and an elliptical fruit body. Previously, Lagokarpos fossils have only been found from North America and Germany, ranging from the latest Paleogene to early middle Eocene. Recently, we found fossil fruits of this genus from the Niubao Formation, near Bangoin County in the central QTP. A new species, namely Lagokarpos tibetensis H. Tang, T. Su & Z. K. Zhou sp. nov., is described. This is the first fossil record of the genus in Asia. The occurrence of L. tibetensis indicates a close floristic linkage between the QTP and other floras in the Northern Hemisphere during the Paleogene. According to the floristic assemblages, we suggest the central QTP experienced a tropical or subtropical humid climate during that period.
Effects of Second Language Pronunciation Teaching Revisited: A Proposed Measurement Framework and Meta‐Analysis
Authors: Saito Kazuya , Plonsky Luke 
Published: May 2019

We propose a new framework for conceptualizing measures of instructed second language (L2) pronunciation performance according to three sets of parameters: (a) the constructs (focused on global vs. specific aspects of pronunciation), (b) the scoring method (human raters vs. acoustic analyses), and (c) the type of knowledge elicited (controlled vs. spontaneous). Adopting this model (Framework for L2 Pronunciation Measurement) as a synthetic tool, we coded the instruments found in 77 studies of L2 pronunciation teaching published between 1982 and 2017. We calculated the frequency of each measurement type and reexamined the interaction of instructional effectiveness and measurement within the sample. According to the results, instruction is most effective when it targets learners’ monitored production of specific segmental or suprasegmental features. The efficacy of instruction remains relatively unclear when gains are measured globally via subjective, human judgments, especially at a spontaneous level.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible via the IRIS database at https://www.iris-database.org. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.