bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human embryoid bodies model basal lamina assembly and muscular dystrophy
Authors: Nickolls Alec R. , Lee Michelle M. , Zukosky Kristen , Mallon Barbara S. , Bönnemann Carsten G. 
Published: September 2019

AbstractThe basal lamina is a specialized sheet of dense extracellular matrix (ECM), linked to the plasma membrane of specific cell types in their tissue context, that serves as a structural scaffold for organ genesis and maintenance. Disruption of the basal lamina and its functions is central to many disease processes, including cancer metastasis, kidney disease, eye disease, muscular dystrophies, and specific types of brain malformation. The latter three pathologies occur in the dystroglycanopathies, which are caused by dysfunction of the ECM receptor dystroglycan. However, opportunities to study the basal lamina in various human disease tissues are restricted due to its limited accessibility. Here, we report the generation of embryoid bodies from human induced pluripotent stem cells to model basal lamina formation. Embryoid bodies cultured via this protocol mimic pre-gastrulation embryonic development, consisting of an epithelial core surrounded by a basal lamina and a peripheral layer of ECM-secreting endoderm. In dystroglycanopathy patient embryoid bodies, electron and fluorescence microscopy revealed ultrastructural basal lamina defects and reduced ECM assembly. By starting from patient-derived cells, these results establish a method for the in vitro synthesis of patient-specific basal lamina and recapitulate disease-relevant ECM defects seen in muscular dystrophies. Finally, we applied this system to evaluate an experimental ribitol supplement therapy on genetically diverse dystroglycanopathy patient samples.
Pencil-on-paper flexible electronics for daily sensing applications
Authors: Liu Yan , Wang Hai , Zhao Wei , Zhang Min , Qin Hongbo 
Published: September 2019

PurposeInspired by the development of eco-friendly flexible electronics, this paper aims to present a series of paper-based electronics drawn by pencils, which can be used as favorable sensing elements in daily life.Design/methodology/approachPencil traces are deposited on the porous surface of Xerox paper by the mechanical exfoliation during writing process, which can be used as basic components to construct functional electronics for daily sensing applications. By changing pencil grade, the obtained traces can work as conductive wires, electrodes, resistors and piezoresistive gauges.FindingsThe experimental results confirm their practical applications in sensing several daily activities, including finger motion, touching and the temperature of water in paper cup. Moreover, the used electronics can be easily handled and recycled.Research limitations/implicationsThe shortage in functionality, reliability and performance consistency induced by manual operation is an evident challenge, which makes the pencil-on-paper devices more suitable to work as a temporary solution to satisfying the demands from emergency circumstances.Originality/valueThe pencil-on-paper devices, motivated by the electroconductibility and piezoresistivity of pencil trace, can be explored as sensing prototypes in detecting daily activities. Meantime, their advances in easy accessibility, rapid fabrication, low cost and eco-fitness endow them excellent capacity of meeting the “on-site, real-time” demands.
Ethics of blockchain
Authors: Tang Yong , Xiong Jason , Becerril-Arreola Rafael , Iyer Lakshmi 
Published: September 2019

Purpose
The purpose of this paper is fourfold: first, to provide the first systematic study on the ethics of blockchain, mapping its main socio-technical challenges in technology and applications; second, to identify ethical issues of blockchain; third, to propose a conceptual framework of blockchain ethics study; fourth, to discuss ethical issues for stakeholders.

Design/methodology/approach
The paper employs literature research, research agenda and framework development.

Findings
Ethics of blockchain and its applications is essential for technology adoption. There is a void of research on blockchain ethics. The authors propose a first theoretical framework of blockchain ethics. Research agenda is proposed for future search. Finally, the authors recommend measures for stakeholders to facilitate the ethical adequacy of blockchain implementations and future Information Systems (IS) research directions. This research raises timely awareness and stimulates further debate on the ethics of blockchain in the IS community.

Originality/value
First, this work provides timely systematic research on blockchain ethics. Second, the authors propose the first research framework of blockchain ethics. Third, the authors identify key research questions of blockchain ethics. Fourth, this study contributes to the understanding of blockchain technology and its societal impacts.
Cross-cultural perspective of situated learning and coping: understanding psychological closeness as mediator
Authors: Bose Mousumi , Ye Lei 
Published: September 2019

Purpose
Extant consumer behavior research has alluded to consumer learning; however, little research exists regarding situated learning and its relation to coping with respect to stressful consumption experiences. The purpose of this research is to study situated or in situ learning in two cultural contexts – that of the USA and China.

Design/methodology/approach
Online data were collected from non-students in both the USA and China, and structural equations modeling was used to analyze data.

Findings
Results demonstrated that situated learning helped cope better with stressful episodes for both cultures. Psychological closeness to the problem mediated the relationship between the antecedents and situated learning for US consumers more than for Chinese consumers.

Research limitations/implications
Since US consumers tend to be psychologically close to the stressor during the consumption process, firms should preemptively inform and educate them about potential stressors to help them learn and cope. However, as Chinese consumers tend not to be psychologically close to the problem, they need to be dealt differently.

Originality/value
This research provides a holistic view of situated learning and coping as a process involving consumers, firms and situations and examines their underlying factors in stressful consumption encounters. It establishes the mediating role of psychological closeness between antecedents and consumers’ situated learning and explores the differences of psychological closeness in two different cultures, that of the USA and China.
The relationship between preference for privacy and social media usage
Authors: Hunter Gary L. , Taylor Steven A. 
Published: September 2019

Purpose
This paper aims to investigate whether preferences for certain types of privacy predict the frequency and duration of social media usage as well as the moderating role of gender on these relationships.

Design/methodology/approach
An e-mail-based survey among the faculty, staff and students of a medium-sized mid-western university is used to gather data regarding preferences for privacy and social media usage. Using 530 respondents, structural equation modeling explores the relationship between the various privacy types, gender and social media usage.

Findings
Evidence supports a relationship between four types of privacy preferences and social media usage. A positive relationship exists between frequency of social media usage and a preference for not neighboring. Duration of social media usage shows a negative relationship with preferences for seclusion and reserve, and surprisingly, a positive relationship with a preference for anonymity. Gender moderates the relationship between preference for privacy and social media usage, offering evidence that intimacy, seclusion and reserve predict social media usage for males, while not neighboring and anonymity predict usage for females.

Originality/value
The study extends the privacy literature through investigating differential impacts of privacy preferences. The marketing literature examines privacy as a general concept, without allowing for differences in consumers' preferences for types of privacy. Additionally, the study shows that gender moderates the relationship between preferences for privacy and social media usage. A second contribution is investigating the relevance of a scale, developed in an age without social media, to an era permeated in social media.
Focal fields in literature on the information divide
Authors: Yang Feng , Zhang Xiaoqian 
Published: September 2019

PurposeThe purpose of this paper is to identify key countries and their focal research fields on the information divide.Design/methodology/approachLiterature was retrieved to identify key countries and their primary focus. The literature research method was adopted to identify aspects of the primary focus in each key country.FindingsThe key countries with literature on the information divide are the USA, China, the UK and India. The problem of health is prominent in the USA, and solutions include providing information, distinguishing users’ profiles and improving eHealth literacy. Economic and political factors led to the urban–rural information divide in China, and policy is the most powerful solution. Under the influence of humanism, research on the information divide in the UK focuses on all age groups, and solutions differ according to age. Deep-rooted patriarchal concepts and traditional marriage customs make the gender information divide prominent in India, and increasing women’s information consciousness is a feasible way to reduce this divide.Originality/valueThis paper is an extensive review study on the information divide, which clarifies the key countries and their focal fields in research on this topic. More important, the paper innovatively analyzes and summarizes existing literature from a country perspective.
Supporting successful data sharing practices in earthquake engineering
Authors: Wu Shuheng , Worrall Adam 
Published: September 2019

Purpose
Prior studies identified a need for further comparison of data-sharing practices across different disciplines and communities. Toward addressing this need, the purpose of this paper is to examine the data-sharing practices of the earthquake engineering (EE) community, which could help inform data-sharing policies in EE and provide different stakeholders of the EE community with suggestions regarding data management and curation.

Design/methodology/approach
This study conducted qualitative semi-structured interviews with 16 EE researchers to gain an understanding of which data might be shared, with whom, under what conditions and why; and their perceptions of data ownership.

Findings
This study identified 29 data-sharing factors categorized into five groups. Requirements from funding agencies and academic genealogy were frequent impacts on EE researchers’ data-sharing practices. EE researchers were uncertain of data ownership and their perceptions varied.

Originality/value
Based on the findings, this study provides funding agencies, research institutions, data repositories and other stakeholders of the EE community with suggestions, such as allowing researchers to adjust the timeframe they can withhold data based on project size and the amount of experimental data generated; expanding the types and states of data required to share; defining data ownership in grant requirements; integrating data sharing and curation into curriculum; and collaborating with library and information schools for curriculum development.
Wireless Emergency Alert messages: Influences on protective action behaviour
Authors: Kim Grace , Martel Andrea , Eisenman David , Prelip Michael , Arevian Armen , Johnson Kerri L. , Glik Deborah 
Published: September 2019

AbstractThe Wireless Emergency Alert (WEA) system delivers text‐based alert and warning messages to notify citizens of imminent, local disaster threats and recommended actions. Although this is a promising new practice in emergency communication, research about how people respond immediately after receiving these messages in real time is sparse. Using a mixed‐methods approach, this study addresses this gap by assessing people's reactivity to WEA messages using experimental simulations of an active shooter and an explosion on a college campus. Only about one in five message recipients took immediate protective action. Quantitative analyses and qualitative interviews suggest individual, message, and situational factors influenced protective action behaviour. These findings inform recommendations to create effective WEA and other text‐based alert and warning messages.
Faecalibacterium prausnitzii‐derived microbial anti‐inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression
Authors: Xu Jihao , Liang Rongrong , Zhang Wang , Tian Kuangyi , Li Jieyao , Chen Xianming , Yu Tao , Chen Qikui 
Published: September 2019

AbstractBackgroundImpaired intestinal barrier structure and function have been validated as an important pathogenic process in type 2 diabetes mellitus (T2DM). Gut dysbiosis is thought to be the critical factor in diabetic intestinal pathogenesis. As the most abundant commensal bacteria, Faecalibacterium prausnitzii (F. prausnitzii) play important roles in gut homeostasis. The microbial anti‐inflammatory molecule (MAM), an F. prausnitzii metabolite, has anti‐inflammatory potential in inflammatory bowel disease (IBD). Thus, we aimed to explore the function and mechanism of MAM on the diabetic intestinal epithelium.Methods16S high‐throughput sequencing was used to analyze the gut microbiota of db/db mice (T2DM mouse model). We transfected a FLAG‐tagged MAM plasmid into human colonic cells to explore the protein‐protein interactions and observe cell monolayer permeability. For in vivo experiments, db/db mice were supplemented with recombinant His‐tagged MAM protein from E. coli BL21 (DE3).ResultsThe abundance of F. prausnitzii was downregulated in the gut microbiota of db/db mice. Immunoprecipitation (IP) and mass spectroscopy (MS) analyses revealed that MAM potentially interacts with proteins in the tight junction pathway, including zona occludens 1 (ZO‐1). FLAG‐tagged MAM plasmid transfection stabilized the cell permeability and increased ZO‐1 expression in NCM460, Caco2, and HT‐29 cells. The db/db mice supplemented with recombinant His‐tagged MAM protein showed restored intestinal barrier function and elevated ZO‐1 expression.ConclusionsOur study shows that MAM from F. prausnitzii can restore the intestinal barrier structure and function in DM conditions via the regulation of the tight junction pathway and ZO‐1 expression.
Increases in methamphetamine use among heroin treatment admissions in the United States, 2008–17
Authors: Jones Christopher M. , Underwood Natasha , Compton Wilson M. 
Published: September 2019

AbstractBackground and AimsDue to their small sample sizes, geographic specificity and limited examination of socio‐demographic characteristics, recent studies of methamphetamine use among people using heroin in the United States are limited in their ability to identify national and regional trends and to characterize populations at risk for using heroin and methamphetamine. This study aimed to examine trends and correlates of methamphetamine use among heroin treatment admissions in the United States.DesignLongitudinal analysis of data from the 2008 to 2017 Treatment Episode Data Set. Descriptive statistics, trend analyses and multivariable logistic regression were used to examine characteristics associated with methamphetamine use among heroin treatment admissions.SettingUnited States.ParticipantsTreatment admissions of people aged ≥ 12 years whose primary substance of use is heroin.MeasurementsPrimary measurement was heroin treatment admissions involving methamphetamine. Secondary measurements were demographics of sex, age, race/ethnicity, US census region, living arrangement and employment status.FindingsThe percentage of primary heroin treatment admissions reporting methamphetamine use increased each year from 2.1% in 2008 to 12.4% in 2017, a relative percentage increase of 490% and an annual percentage change (APC) of 23.4% (P < 0.001). During the study period, increases were seen among males and females and among all demographic and geographic groups examined. Among primary heroin treatment admissions reporting methamphetamine use in 2017, 47.1% reported injecting, 46.0% reported smoking, 5.1% reporting snorting and 1.8% reported oral/other as their usual route of methamphetamine use.ConclusionsMethamphetamine use among heroin treatment admissions in the United States increased from one in 50 primary heroin treatment admissions in 2008 to one in 8 admissions in 2017.
Life‐course trajectories of cannabis use: a latent class analysis of a New Zealand birth cohort
Authors: Boden Joseph M. , Dhakal Bhubaneswor , Foulds James A. , Horwood L. John 
Published: September 2019

AbstractBackground and aimsLittle is known about how cannabis use over the life‐course relates to harms in adulthood. The present study aimed to identify trajectories of cannabis use from adolescence to adulthood and examine both the predictors of these trajectories and adverse adult outcomes associated with those trajectories.DesignA latent trajectory analysis of a longitudinal birth cohort (from birth to age 35 years).Setting and participantsGeneral community sample (n = 1065) from New Zealand.MeasurementAnnual frequency of cannabis use (ages 15–35 years); childhood family and individual characteristics (birth to age 16 years); measures of adult outcomes (substance use disorders, ages 30–35 years; mental health disorders, ages 30–35 years; socio‐economic outcomes at age 35 years; social/family outcomes at age 35 years).FindingsA six‐class solution was the best fit to the data. Individuals assigned to trajectories with higher levels of cannabis use were more likely to have experienced adverse childhood family and individual circumstances. Membership of trajectories with higher levels of use was associated with increased risk of adverse outcomes at ages 30–35 years. Adjustment of these associations for the childhood family and individual predictors largely did not reduce the magnitude of the associations.ConclusionsIn New Zealand, long‐term frequent cannabis use, or transition to such use, appears to be robustly associated with diverse harms in adulthood.
Accuracies of genomic prediction for twenty economically important traits in Chinese Simmental beef cattle
Authors: Zhu B. , Guo P. , Wang Z. , Zhang W. , Chen Y. , Zhang L. , Gao H. , Wang Z. , Gao X. , Xu L. , Li J. 
Published: September 2019

SummaryGenomic prediction has been widely utilized to estimate genomic breeding values (GEBVs) in farm animals. In this study, we conducted genomic prediction for 20 economically important traits including growth, carcass and meat quality traits in Chinese Simmental beef cattle. Five approaches (GBLUP, BayesA, BayesB, BayesCπ and BayesR) were used to estimate the genomic breeding values. The predictive accuracies ranged from 0.159 (lean meat percentage estimated by BayesCπ) to 0.518 (striploin weight estimated by BayesR). Moreover, we found that the average predictive accuracies across 20 traits were 0.361, 0.361, 0.367, 0.367 and 0.378, and the averaged regression coefficients were 0.89, 0.86, 0.89, 0.94 and 0.95 for GBLUP, BayesA, BayesB, BayesCπ and BayesR respectively. The genomic prediction accuracies were mostly moderate and high for growth and carcass traits, whereas meat quality traits showed relatively low accuracies. We concluded that Bayesian regression approaches, especially for BayesR and BayesCπ, were slightly superior to GBLUP for most traits. Increasing with the sizes of reference population, these two approaches are feasible for future application of genomic selection in Chinese beef cattle.
Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia
Authors: Hellström William , Forssell Linnéa , Morsing Eva , Sävman Karin , Ley David 
Published: September 2019

AbstractAimStudies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling‐related blood loss and adult blood transfusions administered during postnatal days 1‐14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation.MethodsThe medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated.ResultsBlood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1‐14 (median 40.4 mL/kg, interquartile range 23.9‐53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume (rS = 0.870, P < .001). Sampling‐related blood loss on postnatal days 1‐7, adjusted for gestational age at birth and birth weight standard deviation score, was associated with the development of bronchopulmonary dysplasia (BPD) (odds ratio by a 10‐unit increase 2.4, 95% confidence interval 1.1‐5.4) (P = .03). No associations were found between blood sampling and intraventricular haemorrhage or necrotising enterocolitis in the full statistical model. The largest proportion of sampling‐related blood was used for blood gas analyses (48.7%).ConclusionDiagnostic blood sampling led to major endogenous blood loss replaced with adult blood components and was associated with the development of BPD.
Review article: impact of exercise on physical frailty in patients with chronic liver disease
Authors: Williams Felicity R. , Berzigotti Annalisa , Lord Janet M. , Lai Jennifer C. , Armstrong Matthew J. 
Published: September 2019

SummaryBackgroundPhysical frailty is common in chronic liver disease and the setting of liver transplantation. It is associated with poor quality of life, increased hospitalisation and mortality. Despite this, the impact of exercise in these patients remains poorly understood.AimTo summarise the impact of physical exercise on physical frailty in patients with chronic liver disease until after liver transplantation.MethodsA MEDLINE and PubMed search was undertaken using the terms; “physical activity”, “functional capacity”, “exercise”, “prehabilitation”, “frailty”, “liver cirrhosis”, “liver failure”, “liver transplantation” “chronic liver disease” and “end‐stage liver disease” from January 1990 to June 2019.ResultsEleven studies (five randomised controlled, five observational, one case study) demonstrated that exercise improves VO2 peak, anaerobic threshold, 6‐minute walk distance, muscle mass/function and quality of life in patients with compensated and decompensated cirrhosis. Improvements were most significant with a combination of aerobic and resistance exercises at moderate‐high intensity. The studies were small (n = 1‐50) and mainly focused on supervised, hospital‐based exercises, excluding patients with significant liver failure (MELD > 12). Seven studies (four randomised controlled and three observational) demonstrated that predominantly supervised (only one home‐based) aerobic exercise after liver transplantation improves aerobic capacity, muscle mass/strength and quality of life. There was marked heterogeneity in timing, intensity and type of exercises.ConclusionExercise improves key components of physical frailty (functional/aerobic capacity, sarcopenia) and quality of life in chronic liver disease and after liver transplantation. Understanding the type, compliance, intensity and duration of exercise and its impact on hard clinical outcomes should be the focus of future large controlled clinical trials.