bluuebunny/crossref_metadata_2025_split huggingface dataset:
2793 Primary Biliary Cholangitis (PBC): Any Differences Between Males and Females?
Authors: Zakharia Kais , Robles Julian , Rasor Madalyn , He Xiaoping , Altamimi Barakat Aburajab , Murali Arvind , Sanchez Antonio J. 
Published: October 2019

INTRODUCTION:
PBC (primary biliary cholangitis) is a cholestatic autoimmune liver disease characterized by destruction of small intrahepatic bile ducts. PBC predominantly affects females but has also been reported in males. Characteristics of PBC in males have not been well described. We aimed to determine the incidence, characteristics, and prognosis of male patients with PBC as compared to females.

METHODS:
We performed a retrospective chart review of all patients with biopsy proven PBC seen at our large tertiary care hospital. We collected data on demographics, clinical and laboratory variables, mortality, and liver transplantation if any. Kaplan-Meier analysis was used to determine time to development of hepatic decompensation in patients with PBC, stratified by gender.

RESULTS:
We included 290 patients with biopsy-proven PBC, 254 (88%) were females and 36 (12%) were males. Mean age at diagnosis of PBC in males versus females was 50 ± 17 vs 54 ± 12 years, respectively (P = 0.09). Body mass index (P = 0.3) and presence of Diabetes (P = 0.06) were comparable between males and females. Mean alkaline phosphatase was similar between both groups at diagnosis, 334 U/L vs 320 U/L (P = 0.61). At the time of diagnosis, 31% of Males had advanced hepatic fibrosis (F3-F4) as compared to 16% of females (P = 0.09) (Table). AMA negative PBC was noted in 16% of females versus 0% of males. Disease progression was higher in males; portal hypertension developed in 42% of males vs 16% in females (P < 0.001), and decompensated cirrhosis was noted in 33% of males versus 10% of females (P < 0.001). Kaplan Meier time to hepatic decompensation showed increased risk of development of hepatic decompensation in males as compared to females (P < 0.001) (see figure). Bone disease was higher in females (osteopenia 22.5% and 6% osteoporosis) than males (12.5% and 3%, respectively).

CONCLUSION:
Male patients with PBC may have advanced fibrosis at diagnosis as compared to females. Additionally, male PBC patients seem to have a more aggressive course as they are more likely to develop portal hypertension and hepatic decompensation as compared to female patients with PBC, despite comparable age, and alkaline phosphatase level at the time of diagnosis. Bone disease was more common in the females as compared to males.
3002 Several Endoscopies Later, Hemosuccus Pancreaticus Comes to Light
Authors: Amin Harshesh , Thomas Mathew , Chand Gaurav , Mishoe Matthew 
Published: October 2019

INTRODUCTION:
Hemosuccus pancreaticus (HP) is an extremely rare cause of upper gastrointestinal bleeding occurring in an estimated one in 1,500 cases. HP is believed to occur through a vascular malformation within the splenic artery leading to intermittent bleeding within the pancreatic duct. The most common causes of HP are due to chronic inflammatory changes from pancreatitis, pseudocysts, or pancreatic malignancy. HP is a challenging diagnosis due to intermittent bleeding, difficulty in localizing anatomical structures, and vague clinical symptoms. Clinically, patients present with vague abdominal pain and intermittent gastrointestinal bleeding not often visualized on EGD, which make diagnosis extremely challenging. Upper GI bleeding can have different etiologies, including but not limited to, peptic ulcer disease, varices, Mallory-Weiss tears, and angioectasis. A rare form of upper GI bleeding can be caused by HP, which is described as bleeding from the pancreatic duct via the Ampulla of Vater. Here we present a case of Hemosuccus Pancreaticus after ruling out common causes.

CASE DESCRIPTION/METHODS:
45-year-old male with medical history significant for chronic pancreatitis complicated by enlarging pancreatic cysts and alcoholic cirrhosis, who presented with melena, left upper quadrant pain, and significant acute blood loss anemia. Patient had several admissions to our facility and underwent several endoscopic procedures without an obvious etiology. During endoscopy on his most recent admission, blood was seen oozing from the ampulla concerning for HP. Patient then had diagnostic angiography by IR notable for distal aneurysm formation communicating with the distal pancreatic duct. Once patient had been discharged, patient had another episode of syncope and was transferred to another facility where he had ultrasound-guided right common femoral artery arteriogram with subsequent coiling of a large pseudoaneurysm arising from the inferior pancreatic artery.

DISCUSSION:
Hemosuccus Pancreaticus is a rare entity but can be seen in patients with chronic pancreatitis, pancreatic pseudocysts, and pancreatic tumors. HP occurs when a direct communication is formed between the pancreatic duct and a vessel after a pancreatic cyst or malignancy erodes into an arterial pseudoaneurysm. Given the fact that this diagnosis is rare and can be potential life-threatening with the rupture of the pseudoaneurysm, it is imperative for physicians to be familiar with the pathology, presentation, and appropriate management of HP.
3208 Small Bowel Obstruction Due to Tuberculous Lymphadenopathy
Authors: Fang Hongfei , Tsai Franklin , Huang Connie Y. , Konijeti Gauree G. 
Published: October 2019

INTRODUCTION:
Mycobacterium tuberculosis is estimated to infect 1.7 billion people worldwide. When untreated, disseminated tuberculosis can occur through hematogenous seeding from primary infection or reactivation of latent disease. Abdominal tuberculosis can be seen in 5% cases of tuberculosis worldwide, with complications such as bowel obstruction resulting from localized infection or tuberculous lymphadenopathy. We present a patient with a history of latent tuberculosis who presented with bowel obstruction secondary to calcified mesenteric lymphadenopathy.

CASE DESCRIPTION/METHODS:
An 82-year old woman was initially seen in Pulmonology clinic regarding latent tuberculosis. Testing was notable for a positive interferon gamma release assay and a chest CT showed calcified lymphadenopathy in the neck and chest. She was started on isoniazid but was unable to tolerate the medication due to dizziness, headaches, and gastrointestinal upset. Over the next year, she developed intermittent abdominal discomfort and was eventually hospitalized for severe abdominal pain, nausea and vomiting. Physical examination revealed stable vital signs and a mildly distended abdomen. Laboratories were notable for a sodium of 129 mmol/L and hemoglobin 11.3 g/dL. An abdominal CT revealed a dilated stomach and duodenum with a transition point in the distal duodenum. There were multiple new calcified mesenteric and retroperitoneal lymph nodes compressing the distal duodenum, causing partial small bowel obstruction (Figure A). Subsequent esophagogastroduodenoscopy demonstrated white plaques in the distal esophagus, consistent with candida esophagitis (Figure B). The stomach and duodenal mucosa appeared endoscopically normal, with exception of narrowing at the second portion of the duodenum. This was suggestive of extrinsic compression and correlated with the area seen on the CT scan (Figure C). Duodenal biopsies were unremarkable. Her presentation was attributed to progressive calcific tuberculous lymphadenopathy and she improved with conservative management. Due to her other comorbidities and intolerance of prior therapy, anti-tubercular treatment was not pursued.

DISCUSSION:
Bowel obstruction is a common complication of abdominal tuberculous. Calcified tuberculous lymphadenopathy should be considered in the differential as a cause for bowel obstruction in patients with a history of untreated latent tuberculosis. Most cases clinically improve with medical therapy; however, in some cases, surgical management is needed.
A modalidade volitiva no discurso de posse de Jair Bolsonaro
Authors: Oliveira André Silva 
Published: October 2019

O presente trabalho se pro-põe a descrever e analisar a modalidade volitiva, que se refere, segundo a Gramática Discursivo-Funcional (GDF) de Hengeveld e Mackenzie (2008), ao que é (in)desejável, tendo por base dois parâmetros: o domínio semântico e a orientação modal. Para isso, foi escolhido o discurso de posse de Jair Bolsonaro, que foi proferido no dia 1º de janeiro de 2019 e disponibilizado on-line. A partir da descrição e da análise qualitativa empreendida, verificamos que a modalidade volitiva se manifesta, no discurso de posse, com orientação para o participante, haja vista que o falante (presidente empossado) tende a expressar suas pretensões em termos de ações políticas em seu mandato que se inicia, envolvendo-se com a performatização do evento sobre o qual incide a volição. Além disso, a modalidade volitiva tende a estar rela-cionada com a não controlabilidade [- controle] do estado-de-coisas, tendo um sujeito animado [+ humano] como fonte da atitude modal, podendo este ser espe-cificado ou não no discurso [± determinado]. Em relação ao tempo e ao modo, o presidente eleito prefere empregar o presente do modo indicativo, situando, desse modo, a volição no momento da enunciação, ainda que o evento esteja localizado em um momento posterior (futuridade).
Effects of cassava flour on the stickiness properties of wheat bread dough: unleavened, leavened and frozen dough
Authors: CHISENGA Shadrack Mubanga , WORKNEH Tilahun Seyoum , BULTOSA Geremew , ALIMI Buliyaminu Adegbemiro 
Published: October 2019

Cassava utilization in the form of cassava-wheat bread is increasing in Africa. However, information on stickiness properties of dough handling under normal and frozen conditions is limited. In view of this the gluten contents and water absorption of doughs, and stickiness of unleavened, leavened and leavened-frozen doughs processed from 0 to 30 % cassava flour substitution level (CFSL) as compared to wheat flour were determined. The gluten contents of flour blends (6.88–13.00 %) decreased significantly (p < 0.05) with increasing CFSL. Water absorption capacity (WAC) was ranged from 59.57–61.70 % and showed positive correlation with gluten contents (r = 0.595, p < 0.05). Cassava variety (CV) and CFSL had significant p < 0.05) influence on stickiness of unleavened (34.14–122.17 g), leavened (13.53–83.94 g) and leavened frozen (126.88–146.82 g) dough. Irrespective of CV and CFSL, frozen dough had the highest stickiness. Gluten content and WAC had significant (p < 0.01) negative influence on stickiness in unleavened (r = -0.445 and -0.437, respectively) and leavened (r = -0.457 and -0.434, respectively) doughs. The variation in stickiness was influenced by gluten contents and CFSL. The unfrozen dough and frozen dough exhibited higher stickiness in lower and higher gluten content flour blends, respectively.
Association studies between grain yield and agronomic traits of a MARS maize (Zea mays L.) population under drought and non-stress condition
Authors: BANKOLE Folusho A , MENKIR Abebe , OLAOYE Gbadebo , OLAKOJO Oloruntoba , MELAKU Gedil 
Published: October 2019

The study aimed at examining the associations between yield and other traits under drought stress and non-stress conditions. A total of 150 MARS testcrosses were evaluated under both conditions at the International Institute of Tropical Agriculture substation for two years under during the dry season. Genotypic and phenotypic correlation, multiple stepwise regression and path co-efficient analyses were carried out to examine the relationship among the traits under both environments. Results showed anthesis-silking interval, days to silking, husk cover and plant aspect were significantly associated with yield under drought condition at both genotypic and phenotypic levels. Yield was positively correlated with plant and ear height but had a negative correlation with plant and ear aspect at both levels under well-watered condition. Regression analysis showed that ears per plant, plant aspect, ear aspect, days to silking, leaf death and plant height had a direct effect on yield, contributing a total of 71.1 % of observed variation under drought, while ears per plant, ear aspect, plant aspect, days to pollen shed, days to silking and plant height contributed about 31.42 % to yield under well-watered conditions. The study concluded that these traits be used as selection criteria as it will aid improvement of maize yield.
F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe
Authors: Hercyk Brian S , Das Maitreyi E 
Published: October 2019

Abstract
Cdc42, a Rho-family GTPase, is a master regulator of cell polarity. Recently, it has been shown that Cdc42 also facilitates proper cytokinesis in the fission yeast Schizosaccharomyces pombe. Cdc42 is activated by two partially redundant GEFs, Gef1 and Scd1. Although both GEFs activate Cdc42, their deletion mutants display distinct phenotypes, indicating that they are differentially regulated by an unknown mechanism. During cytokinesis, Gef1 localizes to the division site and activates Cdc42 to initiate ring constriction and septum ingression. Here, we report that the F-BAR protein Cdc15 promotes Gef1 localization to its functional sites. We show that cdc15 promotes Gef1 association with cortical puncta at the incipient division site to activate Cdc42 during ring assembly. Moreover, cdc15 phospho-mutants phenocopy the polarity phenotypes of gef1 mutants. In a hypermorphic cdc15 mutant, Gef1 localizes precociously to the division site and is readily detected at the cortical patches and the cell cortex. Correspondingly, the hypermorphic cdc15 mutant shows increased bipolarity during interphase and precocious Cdc42 activation at the division site during cytokinesis. Finally, loss of gef1 in hypermorphic cdc15 mutants abrogates the increased bipolarity and precocious Cdc42 activation phenotype. We did not see any change in the localization of the other GEF Scd1 in a Cdc15-dependent manner. Our data indicate that Cdc15 facilitates Cdc42 activation at the division site during cytokinesis at the cell cortex to promote bipolarity and this is mediated by promoting Gef1 localization to these sites.
Screening of nutritional factors through a Plackett-Burman experimental design during the solubilization of tricalcium phosphate by Penicillium hispanicum
Authors: Chan Cupul Wilberth , Jiménez Barrera Dulce Guadalupe , Lezama Gutiérrez Roberto , Ruiz Sánchez Esaú , Pérez Zamora Octavio , Buenrostro Nava Marco Tulio , Manzo-Sánchez Gilberto 
Published: October 2019

Phosphorus plays a fundamental role in plant metabolic processes. Lack of phosphorus in agricultural soils is compensated with chemical fertilizers, which increase the cost of production and contaminate the environment. One approach to avoid this situation is the use of P-solubilizing fungi as biofertilizers. In this study, the solubilization of Ca3(PO4)2 by five native soil-borne micromycetes (SBM) isolated from the rhizosphere of Carica papaya plants was evaluated. The significant nutritional factors involved in the solubilization of Ca3(PO4)2 by Penicillium hispanicum were determined through a Plackett-Burman experimental design (PBED). Both Penicillium SP1 (108.5 mg/L) and P. hispanicum (106.5 mg/L) solubilized 100% of Ca3(PO4)2 at six days of culture. All studied SBM decreased the pH of the culture mediumfrom 4.15 (control) to <2.45. The PBED revealed that the solubilization of Ca3(PO4)2 by P. hispanicum was significantly influenced (P < 0.05) by low values of MnSO4 (0.002 g/L), (NH4)2SO4 (0.25 g/L) and pH (4.0) and a high amount of Ca3(PO4)2 (0.75 g/L). Total protein content was influenced significantly (P <0.05) by low amounts of glucose (5.0 g/L), yeast extract (0.25 g/L), inoculum (1×105 conidia/mL) and pH (4.0) and high amounts of MgSO4 (0.15 g/L), FeSO4 (0.003 g/L) and Ca3(PO4)2 (0.75 g/L). Meanwhile, biomass production was significantly (P < 0.05) influenced by a high level of glucose (15.0 g/L) and inoculum amount (1×107 conidia/mL). In conclusion, P. hispanicum is a good candidate for further field experiments to test Ca3(PO4)2 solubilization in poor soils that lack Cand N sources.
Violência contra mulheres idosas segundo o modelo ecológico da violência
Authors: Rodrigues Rosalina Aparecida Partezani , Giacomini Suelen Borelli Lima , Silva Luípa Michele , Fhon Jack Roberto Silva , Almeida Vanessa Costa , Seredynskyj Fernanda Laporti 
Published: October 2019

Objetivo: compreender os significados e os possíveis fatores de violência segundo o modelo ecológico da violência para idosos que vivem no domicílio.Metodologia: estudo descritivo-exploratório e qualitativo, realizado com 19 idosas. Os dados foram coletados por meio da realização de grupos focais e as falas analisadas baseados em análise temática indutiva, com auxílio do softwareIramuteq.Resultados: o modelo teórico e o conceito sobre a violência possibilitaram a construção de quatro categorias: Os fatores socioeconômicos e a violência contra o idoso; Violência e os fatores individuais; Violência e os fatores sociaise Violência e as relações do idoso com a comunidade.Conclusão: para os idosos, a violência está relacionada aos significados construídos acerca do problema, sobretudo na sociedade atual onde não se sentem respeitados como cidadãos plenos de direitos, mas sim excluídos socialmente.
Fatores de risco associados à exposição de adolescentes à violência sexual
Authors: Souza Valesca Patriota de , Gusmão Tarcila Lima de Alcântara , Neto Waldemar Brandão , Guedes Tatiane Gomes , Monteiro Estela Maria Leite Meirelles 
Published: October 2019

Objetivo: analisar as evidências científicas sobre os fatores de risco associados à exposição de adolescentes à violência sexual.Síntese de conteúdo: revisão integrativa da literatura, realizada em quatro bases de dados e duas bibliotecas virtuais, sem limites do ano de publicação, utilizando-seos descritores: “delitos sexuais”, “adolescentes” e “fatores de risco”. Utilizou-se, também, a palavra-chave “violência sexual” e equivalentes, no idioma inglês. Na análise dos 22 artigos incluídos, os fatores associados à exposição dos adolescentes à violência sexual foram classificados em “abuso sexual” e “exploração sexual”. O consumo de álcool e/ou drogas foi o fator mais evidente, seguido do sexo casual, dabaixa escolaridade, da baixa renda, da violência familiar, dos relacionamentos em ambientes virtuais, da estigmatização do trabalho sexual e falta de moradia.Conclusão: os fatores apresentados devem ser considerados pela enfermagem para o reconhecimento de adolescentes vítimas de violência sexual, além de contribuir na prevenção de novos casos e na minimização dos efeitos que tal ato pode causar na vida desse público.
Sentido de coherencia y estilo de vida promotor de salud en estudiantes del noroeste de México
Authors: Escobar-Castellanos Blanca , Cid-Henríquez Patricia , Sáez Carrillo Katia , Buelna-Barrueta Valerie Raquel , Contreras-Murrieta Dania Judith , Godínez-Morales Brian Jesús , Franco-García Francisco 
Published: October 2019

Objetivo: analizar el sentido de coherencia y su relación con el estilo de vida promotor de salud en estudiantes de una universidad pública en Sonora, México.Metodología: estudio descriptivo y correlacional, participaron 44 estudiantes de las carreras de ciencias de la computación, física y geología. Se empleó una cédula de datos sociodemográficos, la Escala Sentido de Coherencia 13 y el Cuestionario Estilo de Vida II. Se efectuó análisis de datos con medidas de tendencia central y de dispersión, se utilizó el test chi-cuadrado y coeficiente de correlación de Spearman, con un nivel de significancia de alfa 0.05.Resultados: la edad promedio de los estudiantes fue de 20 años, 70,5% eran hombres y solteros, un 52,3% mostró sentido de coherencia global bajo predominando en hombres (54,8%). Un 56,8% obtuvo un estilo de vida promotor de salud insuficiente, mayormente en mujeres (69,2%). El sentido de coherencia tuvo correlación positiva significativa con el estilo de vida promotor de salud (p < 0,05).Conclusiones: la etapa de transición a la vida universitaria es un período importante y crítico para los estudiantes, es prioritario establecer programas de promoción y educación para la salud con enfoque salutogénico, con el propósito de fortalecer el uso de los recursos disponibles y desarrollar un sentido de coherencia más fuerte en los estudiantes, fomentando un estilo de vida promotor de salud permanente.
Success and reliability of extrafemoral Exoseal vascular closure device: “Off-label” usage
Authors: Caymaz Ismail , Nurili Fuad , Kolcak Ozlem , Aras Omer , Gumus Burcak 
Published: October 2019

Aim
The aim of this study is to present the reliability and efficacy of Exoseal vascular closure device (EVCD) for closure of extrafemoral punctures.

Materials and methods
All patients who were treated with EVCD following arterial endovascular treatment involving an extrafemoral puncture between April 2013 and January 2014 were examined retrospectively. This study included 11 patients (4 women and 7 men between the ages of 48 and 87 years; average age = 65 years). A total of 13 procedures were performed in 11 patients involving the following access routes: brachial artery (n = 5), popliteal artery (n = 4), and polytetrafluoroethylene graft (n = 4).

Results
Twelve out of 13 EVCD procedures achieved technical success and procedural success. One minor and one major complications occurred. Both complications were revealed to be pseudoaneurysms, both in the brachial artery. Pseudoaneurysm of the minor complication was treated by Fibrin Sealant (Tisseel) injection guided by ultrasonography and the other pseudoaneurysm was treated by covered stent placement.

Conclusions
The femoral artery is an essential access route of arterial endovascular procedures; however, in some cases, the extrafemoral arterial route is necessary. In this study, EVCD was found to be useful for closing extrafemoral arterial routes. This study had a limited number of cases and more large-scale studies are needed.
A HEDGE ALGEBRAS BASED REASONING METHOD FOR FUZZY RULE BASED CLASSIFIER
Authors: Phong Phạm Đình , Dư Nguyễn Đức , Thông Hoàng Văn 
Published: October 2019

The fuzzy rule based classifier (FRBC) design methods have intensively been being studied during last years. The ones designed by utilizing hedge algebras as a formalism to generate the optimal linguistic values along with their (triangular and trapezoidal) fuzzy sets based semantics for the FRBCs have been proposed. Those design methods generate the fuzzy sets based semantics because the classification reasoning method still bases on the fuzzy set theory. One question which has been arisen is whether there is a pure hedge algebras classification reasoning method so that the fuzzy sets based semantic of the linguistic values in the fuzzy rule bases can be replaced with the hedge algebras based semantic. This paper answers that question by presenting a fuzzy rule based classifier design method based on hedge algebras with a pure hedge algebras classification reasoning method. The experimental results over 17 real world datasets are compared to the existing methods based on hedge algebras and fuzzy sets theory showing that the proposed method is effective and produces good results.