bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum level of endostatin and digital ulcers in systemic sclerosis patients
Authors: Gigante Antonietta , Margiotta Domenico , Navarini Luca , Barbano Biagio , Gasperini Maria L. , D'Agostino Claudia , Amoroso Antonio , Afeltra Antonella , Rosato Edoardo 
Published: March 2018

AbstractPatients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < .05) higher in SSc patients with new DUs than in SSc patients without new DUs (127 ± 31.1 ng/mL vs 116.3 ± 39.7 ng/mL). The Receiver Operating Characteristic (ROC) curves demonstrated good accuracy of new DU prediction for the serum level of endostatin (0.70, P < .01 [95% confidence interval (CI) 0.59‐0.81]). Using a cut‐off value of 116 ng/mL, the odds ratio was 2.609 (CI 1.075‐6.330, P < .05). The serum levels of endostatin are significantly (P < .01) higher in SSc patients with infected DUs than in SSc patients without infected DUs (139.2 [114.6‐340.91] ng/mL vs 117.5 [64.3‐163.9] ng/mL). Serum levels of endostatin are higher in patients with DUs, especially in those with infected DUs.
Effects of uniconazole or gibberellic acid application on the lignin metabolism in relation to lodging resistance of culm in common buckwheat (Fagopyrum esculentum M.)
Authors: Fang X. , Liu X. , Zhang Y. , Huang K. , Zhang Y. , Li Y. , Nie J. , She H. , Ruan R. , Yuan X. , Yi Z. 
Published: March 2018

AbstractLignin plays an important role in increasing the mechanical intensity of culm and improving lodging resistance of culm. In this study, three common buckwheat, Youqiao2 (lodging‐tolerant cultivar; YQ2), Ningqiao1 (middle lodging‐tolerant cultivar; NQ1) and Ukraine daliqiao (lodging‐susceptible cultivar; UD), were used to investigate the effects of spraying exogenous hormones uniconazole (S‐3307) or gibberellic acid (GA3) on lignin metabolism and its relation to lodging resistance in the three common buckwheat cultivars. Results showed that application of S‐3307 significantly increased lignin content and its related enzymes activities of phenylalanine ammonia‐lyase (PAL), 4‐hydroxy cinnamoyl CoA ligase (4CL), cinnamyl alcohol dehydrogenase (CAD) and peroxidase (POD). The major genes involved in lignin synthesis, PAL, CCR (cinnamyl CoA reductase), C4H (cinnamate4‐hydroxylase), 4CL and CCoAOMT (caffeoyl CoA O‐methyltransferase), were all upregulated expression, and COMT (catechol‐O‐methyltransferase) was downregulated. What is more, application of S‐3307 significantly improved the resistance of common buckwheat stem to lodging and increased yield. Whereas, spraying with GA3 caused opposite effect on those characteristics. These results suggested that application of exogenous S‐3307 or GA3 significantly changed the risk of lodging occurred by regulating the lignin metabolism in culms of common buckwheat.
Instant precipitation of KMgF3:Ni2+ nanocrystals with broad emission (1.3‐2.2 μm) for potential combustion gas sensors
Authors: Cao Jiangkun , Guo Hai , Hu Fangfang , Li Liyi , Xu Shanhui , Peng Mingying 
Published: March 2018

AbstractOptical gas sensors present fundamental and industrial importance considering their broad applications. Challenges remain to obtain new photonic materials with broadband emission covering the absorption spectrum of typical combustion gases. Here, broadband near‐infrared (NIR) photoluminescence (PL) spanning the wide absorption spectrum of typical combustion products is realized through instant precipitation of stable cubic perovskite KMgF3:Ni2+ nanocrystals inside an aluminosilicate glass matrix after melt‐quenching. Excited by an 808 nm laser diode, NIR luminescence with a peak centered at ~1624 nm and a bandwidth (FWHM) greater than 315 nm is observed, originating from 3T2g(3F) → 3A2g(3F) electronic transition of octahedral coordinated Ni2+ in KMgF3 GC. Controlled precipitation of these perovskite crystals from a supercooled aluminosilicate melt enables immediate encapsulation and, hence, stabilization in an inorganic glass phase. While the precipitation temperature has only a small effect on crystallite size, it controls the redox state of the melt and the degree of dopant incorporation into the crystalline phase so that PL performance can be optimized. Spontaneous crystallization of perovskite nanocrystals inside glass may offer a new way to stabilize these novel nanocrystals. Moreover, spontaneous crystallization can be attractive in the control of activator partitioning and in the fabrication of composite fiber devices with high transparency and emission gain. In the present case, this offers a potential platform for broadly tunable gain media, for example, for combustion gas sensing.
Pushing the future back: The impact of policy uncertainty on the market pricing of future earnings
Authors: Drake Michael S. , Mayberry Michael A. , Wilde Jaron H. 
Published: March 2018

AbstractWe examine whether policy uncertainty triggered by presidential elections pushes the future back by reducing the extent to which current prices reflect information about future earnings. We estimate future earnings response coefficients (FERCs) for the years 1975–2013, a period that covers ten presidential elections. We find that FERCs are significantly lower (by 11.8%) during presidential election years compared to other years. Additional analyses using pseudo election years, ex‐ante polls, contract prices from the Iowa Electronic Political Market, and cross‐sectional firm characteristics provide corroborating evidence that the lower FERCs during election years are related to policy uncertainty. We also investigate potential explanations for the lower FERCs during election years. We find that the lower FERCs relate to forecasting difficulty rather than to changes in the discount rate or in the amount of noise trading. Finally, we find that market prices move toward future earnings to a greater degree during presidential election years compared with other years once the policy uncertainty is resolved. A trading strategy based on this drift yields significant abnormal returns. Overall, we contribute to the literature by providing the first empirical evidence that shocks to policy uncertainty influence the pricing of earnings information.
Multiple shifts to open habitats in Melastomateae (Melastomataceae) congruent with the increase of African Neogene climatic aridity
Authors: Veranso‐Libalah Marie Claire , Kadereit Gudrun , Stone Robert Douglas , Couvreur Thomas L. P. 
Published: March 2018

AbstractAimAfrican Melastomateae (Melastomataceae) comprise c. 185 species occurring in closed or open habitats throughout sub‐Saharan Africa. We sought to reconstruct biogeographical and habitat history, and shifts in diversification rates of African Melastomateae using a well‐sampled, dated molecular phylogeny.LocationAmericas, sub‐Saharan Africa, Madagascar, SE Asia.TaxonAngiosperms, Melastomataceae, African Melastomateae.MethodsPhylogenetic relationships were estimated based on an extensive sampling of New and Old World Melastomateae, using two nuclear and three plastid markers. Divergence times were estimated in BEAST based on three calibration priors under Bayesian uncorrelated lognormal relaxed clock and birth–death speciation process. The dated phylogeny was used to infer the biogeographical history under a dispersal–extinction–cladogenesis model in “BioGeoBEARS”. The ancestral habitat of African Melastomateae was estimated using maximum likelihood and stochastic character mapping in “Phytools” and “ape” respectively. Finally, shifts in diversification rates were tested using BAMM.ResultsMelastomateae dispersed from South America to Africa during the Oligocene with subsequent dispersals to Madagascar and SE Asia during the Middle Miocene. Ancestral African Melastomateae were adapted to closed habitats with at least 12 shifts to open habitats occurring during the Middle Miocene or Pliocene. Speciation rates steadily increased since the Neogene, and none of the habitat shifts led to a significant increase in diversification rates.Main conclusionsLong‐distance dispersal from South America during the Early Miocene explains the origin of African Melastomateae. The inferred adaptation to open habitats from an ancestrally closed habitat is congruent with the Neogene increase of aridity across Africa. The adaptation to open habitats during the Neogene is an important driver of African plant diversity, but is not always followed by increased diversification rates.
Recognizing spatial patterns of biodiversity during the nineteenth century: The roots of contemporary biogeography
Authors: Juárez‐Barrera Fabiola , Bueno‐Hernández Alfredo , Morrone Juan J. , Barahona‐Echeverría Ana , Espinosa David 
Published: March 2018

AbstractAimWe review the works of three pre‐Darwinian authors—Alexander von Humboldt, Augustin de Candolle and Alphonse de Candolle. Contrary to what other historiographers have claimed, we think that their works were not merely descriptive, nor did they adhere strictly to the inductivist model. Furthermore, the patterns described by these authors are still being studied extensively in biogeography.MethodWe analyse the main concepts provided by these authors on the spatial patterns of biodiversity, and discuss how they served to construct the conceptual framework of contemporary biogeography.ResultsIn the early 19th century, secular naturalists began postulating explanations supported by empirical evidence and based on physical causes. The studied authors were extremely cautious when proposing hypotheses, considering that any statement not based on empirical evidence was mere conjecture. When we analyse the way they developed explanations, it seems evident that they were rather closer to deductive thought than to the orthodox inductivist model. With the rise of Darwinian evolutionism, naturalists lost interest in the spatial patterns of life and began constructing dynamic models where dispersal of individual lineages from northern centres of origin was proposed to explain their current distribution. Paradoxically, even though the evolutionary paradigm soon proved its great explanatory power, it simultaneously promoted a large number of studies in which speculation prevailed.Main conclusionsEven though the practices and methods of current biogeography have changed substantially, the studied patterns are still the same: (1) geographical gradients of richness and biotic replacement, (2) spatial gradients of functional groups, (3) geographical variation of the phenotype, (4) geographical patterns of expansion‐differentiation of single lineages and (5) biogeographical homology. The studied authors not only described rigorously biogeographical patterns, but also proposed explanations about them and even sometimes tested them based on empirical evidence, going beyond the prevalent inductivist canon.
The Rocky Mountains as a dispersal barrier between barn owl (Tyto alba) populations in North America
Authors: Machado Ana Paula , Clément Laura , Uva Vera , Goudet Jérôme , Roulin Alexandre 
Published: March 2018

AbstractAimGeological barriers within a species range play a key role in shaping patterns of genetic variation by restricting gene flow. Mountain ranges are particularly imposing barriers responsible for creating genetic differentiation across multiple taxa, from small amphibians to large mammals and birds. Here, we examined the population structure of North American barn owls (Tyto alba) and investigated whether the Rocky Mountains influence gene flow and dispersal at the continental scale.LocationContinental North America.MethodsWe collected 292 museum samples covering the species range, genotyped them at 20 microsatellite markers and sequenced 410 bp of the mitochondrial gene ND6. Population and landscape genetics tools were used to study range‐wide patterns of structure and identify gene flow barriers. Ring recapture data were also analysed to investigate individual movement patterns and frequency of exchanges between both sides of the Rocky Mountains.ResultsWe found faint overall genetic structure, which is consistent with barn owl's high mobility across its continuous range. Nonetheless, we identified two distinct genetic groups on the western and eastern regions of the Rocky Mountains with a likely contact point through the narrow southern pass between them and the Sierra Madre Occidental in Mexico. Accordingly, most recaptured barn owls remain on the same side of the mountains. The Rockies appear to significantly isolate the populations in the west, which, as a consequence, display lower genetic diversity than their counterparts to the east.Main conclusionsThe Rocky Mountains appear to constrain barn owl dispersal and gene flow. Our study supports the hypothesis that regional landscape barriers can shape gene flow and population structure even in highly mobile organisms.
Inflammatory factor receptor Toll‐like receptor 4 controls telomeres through heterochromatin protein 1 isoforms in liver cancer stem cell
Authors: Zheng Qidi , Xu Jie , Lin Zhuojia , Lu Yanan , Xin Xiaoru , Li Xiaonan , Yang Yuxin , Meng Qiuyu , Wang Chen , Xiong Wujun , Lu Dongdong 
Published: March 2018

AbstractToll‐like receptor 4 (TLR4) which acts as a receptor for lipopolysaccharide (LPS) has been reported to be involved in carcinogenesis. However, the regulatory mechanism of it has not been elucidated. Herein, we demonstrate that TLR4 promotes the malignant growth of liver cancer stem cells. Mechanistically, TLR4 promotes the expression of histone‐lysine N‐methyltransferase (SUV39 h2) and increases the formation of trimethyl histone H3 lysine 9‐heterochromatin protein 1‐telomere repeat binding factor 2 (H3K9me3‐HP1‐TRF2) complex at the telomeric locus under mediation by long non coding RNA urothelial cancer‐associated 1 (CUDR). At the telomeric locus, this complex promotes binding of POT1, pPOT1, Exo1, pExo1, SNM1B and pSNM1B but prevents binding of CST/AAF to telomere, thus controlling telomere and maintaining telomere length. Furthermore, TLR4 enhances interaction between HP1α and DNA methyltransferase (DNMT3b), which limits RNA polymerase II deposition on the telomeric repeat‐containing RNA (TERRA) promoter region and its elongation, thus inhibiting transcription of TERRA. Ultimately, TLR4 enhances the telomerase activity by reducing the interplay between telomerase reverse transcriptase catalytic subunit (TERT) and TERRA. More importantly, our results reveal that tri‐complexes of HP1 isoforms (α, β and γ) are required for the oncogenic action of TLR4. This study elucidates a novel protection mechanism of TLR4 in liver cancer stem cells and suggests that TLR4 can be used as a novel therapeutic target for liver cancer.
On the determinants and consequences of informal contracting
Authors: Gil Ricard , Zanarone Giorgio 
Published: March 2018

AbstractAs documented by Macauley and others, informal contracts are pervasive in modern economies. Yet, systematic empirical evidence on them is still limited. In this paper, we provide a framework to investigate the determinants and consequences of informal contracting. First, we present an illustrative model that organizes key predictions from the theoretical literature. Next, we discuss selected empirical works that shed light on the model's relevance and testability. Overall, we find combined support for most theoretical predictions from the model, and we observe that significant progress has been made over time at measuring key determinants of informal contracting such as the parties’ discount factor and fallback option. We conclude by discussing strategies for testing theoretical predictions for which conclusive evidence is still missing.
Peer‐to‐peer sharing in the lodging market: Evaluating implications for social welfare and profitability
Authors: Gal‐Or Esther 
Published: March 2018

AbstractWith a focus on the lodging market, we investigate the nature of competition between a peer‐to‐peer platform and a traditional lodging provider (hotel), in an environment where both possess the market power to affect the final lodging price established in the market. To understand such an environment, we investigate the strategy choices of the three types of players active in this market: the platform, the hotel, and individuals in the population who consider supplying or demanding lodging capacity. We use our analysis to predict how the emergence of the peer‐to‐peer platform affects the profits of the hotel and the welfare of consumers. We characterize two types of equilibria: Partial Coverage and Full Coverage. The former type arises if each individual's demand for lodging while on vacation is relatively low in comparison to her supply. In this case, the level of demand originating from vacationers is insufficient to make it worthwhile for the platform to lower its service fee in order to attract capacity from every individual in the population. In contrast, when the demand for lodging while on vacation is relatively high, it may become profitable for the platform to implement the Full Coverage equilibrium, in which case every individual supplies lodging capacity to the platform. We demonstrate that the entry of the platform to the market will definitely increase the consumer surplus if the platform chooses to implement the Full Coverage equilibrium. At the Partial Coverage equilibrium, the consumer surplus might actually decline upon the entry of the platform. This might happen because the entry of the platform can sometimes lead to higher lodging prices, and as a result, can hurt individuals when vacationing. Because the entry of the platform raises the income of individuals in the economy, their willingness to pay for lodging while on vacation may rise. Such higher prices may also sometimes lead to higher profits for the hotel, in spite of the competition with the platform. In the special case that individuals experience no disutility when offering a portion of their housing space to the platform because this space has no alternative use for the individual, the entry of the platform will always lead to higher consumer welfare and lower profits for the hotel, irrespective of whether Full or Partial Coverage arises as equilibrium.
Prevalence of spinal abnormalities in Chinook salmon smolt and influence of early rearing temperature and growth rates
Authors: Munday J S , Perrott M R , Symonds J E , Walker S P , Preece M A , Davie P S 
Published: March 2018

AbstractSpinal abnormalities can be detected at harvest in around 40% of farmed Chinook salmon in New Zealand. However, whether these abnormalities are present in smolt is unknown. Radiographs of 3,736 smolt were taken immediately prior to transfer to sea water and evaluated for fusions, compressions, vertical shifts, and lordosis, kyphosis and/or scoliosis (LKS). The survey included smolt from two different chilling strategies that had been graded into slow‐ or fast‐growing fish. Overall, 4.34% of Chinook salmon smolt had at least one spinal abnormality, similar to the rates of reported in Atlantic salmon smolt. The rate of abnormality was significantly higher in faster‐growing fish. Fusions were most common with 2.68% of smolt affected. Smolt subjected to longer chilling times had lower rates of fusions. Compressions and vertical shifts were both observed in 1.31% of smolt. Although LKS is the most common abnormality of harvested fish, LKS was detected in just five smolt. The results suggest that some fusions in harvest fish have developed at the time of seawater transfer while LKS develops late in the production cycle. Overall, spinal abnormalities are uncommon in Chinook salmon smolt and may be influenced by chilling times and growth rates.
Analysis of Episodes of Care in Medicare Beneficiaries Newly Diagnosed with Alzheimer's Disease
Authors: Khandker Rezaul K. , Black Christopher M. , Xie Lin , Kariburyo M. Furaha , Ambegaonkar Baishali M. , Baser Onur , Yuce Huseyin , Fillit Howard 
Published: March 2018

ObjectivesTo study transitions between healthcare settings and quantify the cost burdens associated with different combinations of transitions during a 6‐month period before initial Alzheimer's disease (AD) diagnosis so as to investigate how using an episode‐of‐care approach to payment for specific disease states might apply in AD.DesignA retrospective observational cohort study.SettingUnited States.ParticipantsA random sample of 8,995 individuals aged 65 to 100 with a diagnosis of AD (International Classification of Diseases, Ninth Revision, Clinical Modification code 331.0) were identified from the Medicare database between January 1, 2011, and June 30, 2014. This analysis identified individuals with AD diagnosed in inpatient (18%), skilled nursing facility (SNF) (1%), hospice (4%), and home and outpatient (77%) settings and analyzed episodes that began in the index setting (defined as the care setting in which the individual was first diagnosed with AD).MeasurementsStudy outcomes included number of transitions between settings, primary discharge diagnoses, and total all‐cause healthcare costs during the 6 months after the AD diagnosis.ResultsThe average numbers of transitions between care settings were 2.8 originating from an inpatient setting, 2.4 from a SNF, 0.3 from a hospice setting and 0.7 from a home or outpatient setting during 6 months post‐AD diagnosis. The overall cost burden during the 6 months after AD diagnosis (including costs incurred at the index setting) was high for individuals diagnosed in a nonambulatory setting (mean $41,468). Individuals diagnosed in an ambulatory setting incurred only $12,597 in costs during the same period.ConclusionEpisodes of care can be defined and studied in individuals with AD. An episode‐of‐care approach to payment could encourage providers to use the continuum of care needed for quality medical management in AD more efficiently.
Record of plate boundary metamorphism during Gondwana breakup from Lu–Hf garnet geochronology of the Alpine Schist, New Zealand
Authors: Briggs Sophie I. , Cottle John M. , Smit Matthijs A. 
Published: March 2018

AbstractThe Zealandia portion of the Pacific–Gondwana margin underwent widespread extension, fragmentation, separation and subsidence during the final stages in the breakup of Gondwana. Although these processes shaped the geology of New Zealand, their timing and the timing of subduction cessation in the region remain unclear. To investigate the timing of these processes, we used Lu–Hf garnet geochronology to date six samples of the Alpine Schist, which represents the metamorphic section of the former Zealandia margin. The garnet dates range from 97.3 ± 0.3 to 75.4 ± 1.3 Ma. Compositional zoning in garnet indicates that the spread in ages results from diachronous metamorphism in the upper plate at the Pacific–Gondwana margin, occurring concurrently with rifting of Zealandia from East Gondwana via opening of the Tasman Sea. Clear spatial trends in the timing of garnet growth throughout the Alpine Schist are absent, indicating that either regional age trends were offset by post‐metamorphic deformation, or that metamorphism did not result from a single regional heat source, and was instead driven by short‐duration, spatially dispersed processes such as episodic fluid‐fluxing or mechanical heating. Diachronous metamorphism of the Alpine Schist can be attributed to heat conduction from the rising upper mantle during widespread extension, progressive burial and heating of accretionary wedge sediments during ongoing horizontal shortening, or fluid‐fluxing sourced from a subducting and dehydrating Hikurangi Plateau. These results indicate that during separation of Zealandia from East Gondwana in the late Cretaceous, the crust at the Pacific–Gondwana margin remained hot, potentially facilitating the extensive thinning of the Zealandia lithosphere during this time.