bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative KOOS and SF-36 Scores Are Associated With the Development of Symptomatic Knee Osteoarthritis at 7 Years After Anterior Cruciate Ligament Reconstruction
Authors: Ware J. Kristopher , Owens Brett D. , Akelman Matthew R. , Karamchedu Naga Padmini , Fadale Paul D. , Hulstyn Michael J. , Shalvoy Robert M. , Badger Gary J. , Fleming Braden C. 
Published: February 2018

Background: Anterior cruciate ligament (ACL) tears are associated with the development of knee osteoarthritis despite ACL reconstruction surgery. However, little evidence is available to determine which patients will develop symptomatic knee osteoarthritis. Purpose: To determine if preoperative outcome measures—KOOS (Knee injury and Osteoarthritis Outcome Score) and SF-36 (36-item Short Form Health Survey)—were associated with the development of a symptomatic knee 7 years after ACL reconstruction. A secondary goal was to examine the relationship between imaging evidence of knee osteoarthritis and development of knee pain. Study Design: Case-control study; Level of evidence, 3. Methods: Prospectively collected data from 72 patients were reviewed with 7-year follow-up after unilateral ACL reconstruction. Patients were divided into symptomatic and asymptomatic groups based on the previously defined KOOS pain ≤72. Demographic variables and preoperative KOOS and SF-36 scores were compared between groups. Radiographic and magnetic resonance imaging data were used to evaluate differences in joint space width, Osteoarthritis Research Society International radiographic score, and the Whole-Organ Magnetic Resonance Imaging Score between groups. Univariate and multivariate analyses were performed to identify potential predictors of pain at 7-year follow-up. Wilcoxon sum rank and t tests were used to compare imaging findings between the symptomatic and asymptomatic patients at 7 years. Results: According to KOOS pain, 7 of the 72 patients available at 7-year follow-up formed the symptomatic group. No differences were found between groups in regard to demographic variables or intraoperative findings. In multivariate analysis, lower preoperative scores for KOOS sports/recreation ( P = .005) and SF-36 mental health ( P = .025) were associated with a painful knee at 7 years, with increased odds of 82% and 68% per 10-unit decrease, respectively. The Whole-Organ Magnetic Resonance Imaging Score at 7 years showed evidence of osteoarthritic changes in the symptomatic group as compared with the asymptomatic group ( P = .047). However, there were no significant differences in the Osteoarthritis Research Society International radiographic score ( P = .051) or joint space width ( P = .488) between groups. Conclusion: Lower preoperative KOOS and SF-36 scores were associated with those patients who developed symptomatic knee osteoarthritis 7 years after ACL reconstruction.
Could stool collection devices help increase uptake in bowel cancer screening programmes?
Authors: Morling JR , Barke AN , Chapman CJ , Logan RF 
Published: February 2018

Objective To understand the usage and acceptability of a faecal collection device amongst participants in the National Health Service Bowel Cancer Screening Programme, with the aim of influencing future uptake. Setting Participants completing faecal occult blood test retests as part of the routine Bowel Cancer Screening Programme in Eastern England. Methods A faecal collection device and questionnaire were sent to all potential retest participants during a one-month period to collect information on prior stool collection methods and ease of use and usefulness of the enclosed faecal collection device. Results Out of 1087 participants invited, 679 (62.5%) returned their questionnaire. Of these, 429 (63.2%) trialled the faecal collection device at least once, 163 (38.4%) found the device made collecting their sample easier than previously, 189 (44.6%) found it made collection more difficult and 72 (17.0%) said it made no difference. Similar numbers reported finding that the faecal collection device made collecting the sample more pleasant (130, 31.5%), less pleasant (103, 25.0%) and no different (179, 43.4%) compared with previous collection without a faecal collection device. Conclusion Although a small proportion of participants found the faecal collection device helpful, a considerable majority did not or did not use it at all. Offering faecal collection devices is unlikely to produce a substantial increase in bowel cancer screening uptake.
Βιβλιοκρισία:ΑΝΑΣΤΑΣΙΑ ΚΟΝΤΟΓΙΑΝΝΟΠΟΥΛΟΥ, Τοπικά συμβούλια στις βυζαντινές πόλεις. Παράδοση και εξέλιξη (13ος-15ος αι).Ακαδημία Αθηνών. Κέντρον Ερεύνης Μεσαιωνικού και Νέου Ελληνισμού, Αθήνα 2015, 172 σελ. . ISBN 978-960-404-305-7
Authors: ΚΑΤΣΩΝΗ Πολύμνια Γ. 
Published: February 2018

Βιβλιοκρισία:ΑΝΑΣΤΑΣΙΑ ΚΟΝΤΟΓΙΑΝΝΟΠΟΥΛΟΥ, Τοπικά συμβούλια στις βυζαντινές πόλεις. Παράδοση και εξέλιξη (13ος-15ος αι).Ακαδημία Αθηνών. Κέντρον Ερεύνης Μεσαιωνικού και Νέου Ελληνισμού, Αθήνα 2015, 172 σελ. ISBN 978-960-404-305-7
Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts.
Authors: Woroń Jarosław , Siwek Marcin 
Published: February 2018

Cel pracyocena występowania niekorzystnych interakcji leków psychotropowych z preparatami ziołowymi (PZ) tj. lekami roślinnymi oraz suplementami diety , które zawierają wyciągi roślinne.MetodaAnaliza 147 przypadków wystąpienia objawów niepożądanych, o obrazie klinicznym wskazującym w stopniu prawdopodobnym lub pewnym, że były one skutkiem dołączenia PZ do stosowanej farmakoterapii, której istotną częścią były leki psychotropowe.WynikiNajczęściej spotykanym skutkiem interakcji leków przeciwdepresyjnych z grupy SSRI lub SNRI z PZ były powikłania krwotoczne, wynikające z dołączenia miłorzębu japońskiego (27,45% wszystkich powikłań w tej podgrupie). Kolejnym częstym powikłaniem był zespół serotoninowy (ZS) (11,8%), pojawiający się w trakcie stosowania żeńszenia (jeden przypadek ZS wystąpił po dołączeniu bacopa). W grupie leków przeciwpsychotycznych największą ilość interakcji stwierdzono w przypadku haloperidolu, a spośród PZ największa ilość powikłań (29.8%) wiązała się z zastosowaniem żeńszenia (w tym 6 przypadków komorowych zaburzeń rytmu w połączeniu z haloperidolem), ostropestu plamistego (w tym 7 przypadków zapalenia trzustki w połączeniu z haloperidolem lub risperidonem oraz 1 przypadek hepatotoksyczności po dołączeniu do aripiprazolu) i różańca górskiego. W grupie leków nasennych i uspokajających najczęściej notowano interakcje z żeńszeniem, głównie w postaci nasileni działania sedatywnego, zaburzeń poznawczych i świadomości. W 132 przypadkach odstawienie preparatu roślinnego spowodowało zmniejszenie nasilenia opisywanych objawów niepożądanych lub ich całkowite ustąpienie.WnioskiPZ (zwłaszcza z żeńszenia , różeńca górskiego, miłorzębu japońskiego, ostropestu) obarczone są znaczącym ryzykiem interakcji farmakokinetycznych i farmakodynamicznych z lekami psychotropowymi. Ze względu na wynikające z tego powikłania i działania niepożądane, każda decyzja dotycząca dołączenia preparatu ziołowego powinna być poprzedzona szczegółową analizą bezpieczeństwa oraz bilansu korzyści i ryzyka.
Eine komperative und kritische Analyse islamischer Stiftungen
Authors: Çizakça Murat 
Published: February 2018

Zusammenfassung
Fromme islamische Stiftungen blicken auf eine jahrhundertealte Tradition zurück, sie können alszivilgesellschaftliche Organisationen avant la lettre angesehen werden. Nachdem Kolonialpolitik und postkoloniale Modernisierungsbestrebungen zu ihrer Zurückdrängung in weiten Teilen der islamischen Welt führten, wird ihre Bedeutung für muslimische Gesellschaften wieder zunehmend wertgeschätzt. Um diese Trendwende zu unterstützen sind jedoch konkrete Gesetzesinitiativen notwendig.
Predominantly Black Institutions and Public Montessori Schools: Reclaiming the “Genius” in African American Children
Authors: Jor’dan Jamilah R. 
Published: February 2018

Abstract
There are more than 22,000 Montessori schools in over 100 countries worldwide. Beginning in the 1950s the American Montessori movement was primarily a private pre-school movement. There are more than 5,000 schools in the United States; over 500 of these are public. Montessori schools are an increasingly popular choice in the U.S. for public school districts looking to improve their educational outcomes. Predominantly Black Institutions (PBIs) can play a pivotal role by integrating Montessori education within their teacher preparation programs. As the demand for Montessori education increases there will be a need for more highly-qualified, culturally and linguistically diverse teachers who have the appropriate credentials and can implement the Montessori approach. Scientific research confirms that children who attend Montessori schools are advantaged academically, socially and emotionally. Communities such as Milwaukee and Chicago are now implementing Montessori education through public schools as part of school reform efforts making the educational approach more accessible to African American children.
The Functional Specialization of Exomer as a Cargo Adaptor During the Evolution of Fungi
Authors: Anton Carlos , Taubas Javier Valdez , Roncero Cesar 
Published: February 2018

AbstractYeast exomer is a heterotetrameric complex that is assembled at the trans-Golgi network, which is required for the delivery of a distinct set of proteins to the plasma membrane using ChAPs (Chs5-Arf1 binding proteins) Chs6 and Bch2 as dedicated cargo adaptors. However, our results show a significant functional divergence between them, suggesting an evolutionary specialization among the ChAPs. Moreover, the characterization of exomer mutants in several fungi indicates that exomer’s function as a cargo adaptor is a late evolutionary acquisition associated with several gene duplications of the fungal ChAPs ancestor. Initial gene duplication led to the formation of the two ChAPs families, Chs6 and Bch1, in the Saccaromycotina group, which have remained functionally redundant based on the characterization of Kluyveromyces lactis mutants. The whole-genome duplication that occurred within the Saccharomyces genus facilitated a further divergence, which allowed Chs6/Bch2 and Bch1/Bud7 pairs to become specialized for specific cellular functions. We also show that the behavior of S. cerevisiae Chs3 as an exomer cargo is associated with the presence of specific cytosolic domains in this protein, which favor its interaction with exomer and AP-1 complexes. However, these domains are not conserved in the Chs3 proteins of other fungi, suggesting that they arose late in the evolution of fungi associated with the specialization of ChAPs as cargo adaptors.
Management of advanced otosclerosis: experience in a tertiary care centre
Authors: Alam Mohammed Iftekharul , Natarajan Kiran , Singh Takhellambam Biram , Kumari Abha , Kameswaran Mohan 
Published: February 2018

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Advanced otosclerosis affects approximately 10% of patients with otosclerosis. Ossification of the cochlea increases with the course of the disease and may cause sensori-neural or mixed hearing loss. Hearing aids, stapedotomy and cochlear implants are management options for hearing loss associated with advanced otosclerosis. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A retrospective study of 153 patients with advanced otosclerosis was done in a tertiary ENT centre. 110 patients with advanced otosclerosis underwent stapedotomy and 43 patients with advanced otosclerosis underwent cochlear implantation (CI) from 1997 till date. Exclusion criteria included patients with profound hearing loss from causes other than otosclerosis. The aim was to study the indications, selection criteria, as well as surgical issues of stapedotomy and cochlear implantation in patients with advanced otosclerosis. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Stapedotomy followed by use of hearing aid was found to give good outcomes in advanced otosclerosis. Patients with advanced otosclerosis who had poor pre-operative speech discrimination underwent CI. Complete insertion was possible in 39 patients and partial insertion was done in 4 patients. The outcomes of cochlear implantation were found to be satisfactory. Facial nerve stimulation was seen in 5 patients who underwent CI; however this was successfully managed by reprogramming or switching off the concerned electrodes. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">In our experience, stapedotomy or CI in advanced otosclerosis has proven successful, with a low complication rate. The selection criteria for stapedotomy versus CI have to be stringent for optimal outcomes.</span></p>
Locational Analysis of the Productive Structure of the Micro-Region of Porto Nacional
Authors: De Sousa Ronildo Borges , Almeida Géssika Teixeira , De Oliveira Nilton Marques , Da Luz Rodolfo Alves 
Published: February 2018

Abstract: this paper analyzes the location pattern of productive activities in the microregion of Porto Nacional - TO, in 2005 and 2015. It was used the regional analysis method through the indicators of location, particularly, the Locational Quotient (QL), the Hirschman Herfindahl concentration index (HHI), the geographic association coefficient (CAG) and the employment multiplier. The theoretical framework was based in the concept of regional economy on the theory of location of the productive sectors. The results indicated that the QL of the 11 cities of the micro-region has diversified economic base activities and that the branch of activity that most employs is the public administration. Palmas presented the largest employment multiplier, 20.13 in 2005 and 16.02 in 2015, that is, the most representative of the microregion.Análise Locacional da Estrutura Produtiva da Microrregião de Porto NacionalResumo: o presente trabalho tem o objetivo de analisar o perfil de localização das atividades produtivas no espaço da microrregião de Porto Nacional – TO, para os anos de 2005 e 2015. Para tanto, foi utilizado o método de análise regional com o uso dos indicadores de localização, o quociente locacional (QL), o Índice de concentração de Hirschman Herfindahl (IHH), o coeficiente de associação geográfica (CAG) e o multiplicador de emprego. Para a fundamentação teórica foi usado o conceito de economia regional sobre a teoria de localização dos setores produtivos. Os resultados apontaram que o QL dos 11 municípios da microrregião possui atividades de base econômicas diversificadas e que o ramo de atividade que mais emprega é a administração pública. Palmas apresentou o maior multiplicador de emprego, 20,13 no ano de 2005 e 16,02 em 2015, ou seja, o mais representativo da microrregião.Analisis de la Localización de la Estructura Productiva de la Microregión de Porto NacionalResumen: el presente trabajo tiene el objetivo de analizar el perfil de localización de las actividades productivas en el espacio de la microrregión de Porto Nacional – TO, para los años de 2005 y 2015. Para ello, fue utilizado el método de análisis regional con el uso de los indicadores de localización, el cociente locacional (QL), el Índice de concentración de Hirschman Herfindahl (IHH), el coeficiente de asociación geográfica (CAG) y el multiplicador de empleo. Para la fundamentación teórica fue usado el concepto de economía regional sobre la teoría de localización de los sectores productivos. Los resultados señalaron que el QL de los 11 municipios de la microrregión posee actividades de base económicas diversificadas y que el ramo de actividad que más emplea es la administración pública. Palmas presentó el mayor multiplicador de empleo, 20,13 el año de 2005 y 16,02 el 2015, o sea, el más representativo de la microrregión.
Применение микрочипов для идентификации происхождения генов вирусов гриппа диких птиц
Authors: Гейдаров Р. Н. , Ломакина Н. Ф. , Боравлева Е. Ю. , Холодилов И.С. , Гамбарян А. С. , Михайлович В. М. , Фесенко Е. Е. 
Published: February 2018

В черте города Москвы из фекалий диких водоплавающих птиц изолировали 42 штамма вируса гриппа птиц и проанализировали их на микрочипах «Биогрипп», которые содержат 176 зондов к различным участкам генома вирусов гриппа. Микрочип позволяет определять: 1) субтип поверхностных белков гемагглютинина и нейраминидазы; 2) структуру С-концевой последовательности вирусного белка NS1, влияющую на степень ингибирования транскрипции клеточных хозяйских генов, в том числе ответственных за синтез интерферона; 3) наличие стоп-кодонов и мутацию N66S в рамке считывания вирусного белка PB1-F2, 4) наличие полиосновного сайта протеолитического расщепления гемагглютинина.
Среди изолятов от диких птиц идентифицированы вирусы гриппа субтипов H3N1, H3N6, H3N8, H4N6, H1N1, H5N3 и H11N9. Все они содержали последовательность ESEV на С-конце белка NS1, полноразмерную рамку считывания для белка PB1-F2. Замена N66S в PB1-F2 обнаружена у шести штаммов. Однако такие маркеры патогенности, как последовательность ESEV (лиганд PDZ-домена) в вирусном белке NS1 и замена N66S PB1-F2 в контексте генома вирусов гриппа диких уток, не делали вирус патогенным для мышей. Все изоляты были высокоурожайны в куриных эмбрионах, инфекционны и иммуногенны для мышей, но не вызывали у этих животных клинических симптомов заболевания.
Organik Kuru İncir Meyvelerinde Farklı Ambalajların Raf Ömrü Süresince Kaliteye Etkileri
Authors: KURUÇAYLI Hasan , ŞEN Fatih 
Published: February 2018

&nbsp;

Çalışma, farklı
ambalajlarla paketlenen organik kuru incir meyvelerinin raf ömrü süresince
kalite değişimlerinin belirlenmesi amacıyla yürütülmüştür. Organik olarak
üretilen kuru incir (cv. Sarılop) meyveleri natürel olarak doypack, tray,
quadro ve polietilen (PE) torba ambalajlarına yerleştirilmiştir. Bu ambalajlar
20±1ºC’de %50-65 oransal nemde 6 ay süreyle muhafaza edilmiştir. Ambalaj
tiplerinin kuru incir meyvelerinin nem miktarını etkileyerek sertlik, suda
çözünür kuru madde miktarı ve su aktivitesinde artış veya azalışlara neden
olduğu saptanmıştır. Depolama sonunda kuru incir meyvelerinin nem miktarı
doypack ambalajında en yüksek (%19.84), PE torbada ise en düşük (%18.26)
bulunmuştur. PE torbadaki kuru incirlerin sertlik değerlerinin diğer
ambalajlara göre depolama sonunda %14.8 daha yüksek olduğu saptanmıştır.
Depolama sonunda quadro ambalajındaki kuru incirlerin yüzeyindeki şekerlenme
indeksi 3.89 ile en yüksek bulunmuştur. Genel olarak ambalajların organik kuru
incir meyvelerinin rengine ve incelenen diğer kalite parametrelerine etkileri
sınırlı olmuştur. Sonuçlar, doypack ambalajının organik kuru incir için
önerilebileceğini, PE torba ambalajında ise bazı kalite parametreleri ile
ilgili sorunlar yaşanabileceğini göstermiştir.
Application of starch-based edible coating enriched with lemongrass oil as antimicrobials to improve shelf life of red-bell pepper
Authors: Widaningrum NFN , Miskiyah NFN , Winarti Christina 
Published: February 2018

<p>Red-bell peppers (<em>Capsicum annuum var. Athena</em>) is a perishable vegetable, so it is necessary to improve its shelf life. The edible coating technology can potentially be used to increase shelf life and improve microbiological quality of paprika. This study aimed to determine the effect of sago starch-based coating material with incorporation of natural antimicrobial lemongrass oil on the characteristics of red-bell pepper during storage at 20 and 8°C. The study included preparation of sago starch-based coating material with the addition of lemongrass oil as antimicrobial, their application on red-bell pepper and analysis of physical properties as well as the total microbial during storage. The research design used was factorial completely randomized design consisting of two factors (concentration of lemongrassoil as an antimicrobial and dipping time) with three replications. The results showed that the best treatment was dipping of red-bell peppers into coating formula containing lemongrass oil 0.2% for 5 minutes and storing at 8°C. This treatment provided enhancement of red-bell pepper shelf life up to 7 days with the acceptable total microbials and quite fresh conditions.</p><p> </p><p><strong>APLIKASI BAHAN PENYALUT BERBASIS PATI SAGU DAN ANTIMIKROBA MINYAK SEREH UNTUK MENINGKATKAN UMUR SIMPAN PAPRIKA (<em>Capsicum Annum Var. Athena</em>) MERAH</strong></p><p>Paprika (<em>Capsicum annuum var. Athena</em>) termasuk jenis bahan pangan yang mudah rusak, sehingga diperlukan upaya untuk meningkatkan umur simpannya. Teknologi bahan penyalut potensial digunakan untuk meningkatkan masa simpan dan memperbaiki mutu mikrobiologis paprika. Penelitian ini bertujuan mengetahui pengaruh penggunaan bahan penyalut berbasis pati sagu dengan inkorporasi antimikroba alami minyak sereh terhadap karakteristik paprika merah selama penyimpanan pada suhu 20 dan 8° C. Penelitian meliputi pembuatan bahan penyalut berbasis pati sagu dengan penambahan minyak sereh sebagai antimikroba, aplikasinya pada paprika merah, dan analisis sifat fisik serta total mikrobanya selama penyimpanan. Rancangan penelitian yang digunakan yaitu rancangan acak lengkap pola faktorial yang terdiri atas dua faktor (konsentrasi minyak sereh sebagai antimikroba dan lama pencelupan) serta dilakukan sebanyak tiga kali ulangan. Hasil penelitian menunjukkan bahwa perlakuan terbaik adalah perlakuan paprika merah dengan pencelupan selama 5 menit dalam formula bahan penyalut yang ditambah minyak sereh sebagai antimikroba pada konsentrasi 0,2% dan disimpan pada suhu 8 °C. Pada perlakuan tersebut, paprika merah mampu meningkat masa simpannya sampai 7 hari dengan jumlah total mikroba yang masih dapat diterima dan kondisi yang cukup segar.</p>
STUDI FENOMENOLOGIS: MANTAN KORBAN PERKOSAAN YANG MENJADI WOUNDED HEALER
Authors: Abimanyu C.V.R. 
Published: February 2018

Penelitian ini bertujuan untuk mengungkap dinamika makna
hidupseorang korban perkosaan hingga menjadi wounded healer. Subjek
dalam penelitian ini adalah seorang wanitayang pernah menjadi korban
perkosaan pada usia 12 tahun dan memperoleh terapi psikologis pada
usia 23 tahun, kemudian menjadi relawan untuk pendampingan anak
yang menjadi korban perkosaan. Hasil penelitian menunjukkan bahwa
Subjek melalui seangkaian proses panjang hingga pada suatu titik
menghayati bahwa ternyata luka mendalam subjek di masa lalu dapat
menjadi berguna bagi kehidupannya di masa kemudian untuk dapat
mendampingi anak yang menjadi korban perkosaan.Menjadi catatan
penting bahwa tahapan tersebut tidak mungkin dicapai tanpa
penerimaan dan dukungan dari orang-orang terdekatnya.