bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of physical activity and sedentary time with psychological distress among Japan self-defense forces personnel dispatched overseas: a prospective cohort study
Authors: Noguchi Norihito , Shoji Kotaro , Sasai Hiroyuki , Kitano Masato , Waki Fumiko , Edo Naoki , Saito Taku , Sawamura Takehito , Nagamine Masanori 
Published: November 2024

Abstract

Objectives
Physical inactivity and sedentary time can worsen mental health; however, their relationship remains elusive, and related evidence among workers with overseas assignments is limited. Therefore, this study aimed to investigate the relationship between changes in physical activity and sedentary time and explored the subsequent risk of psychological distress among Japan Self-Defense Forces personnel.

Methods
This prospective study enrolled male Japan Self-Defense Forces personnel dispatched to the Republic of Djibouti from May 2018 to June 2019. Psychological distress data were collected before and after overseas deployment. Physical activity and sedentary time data were obtained using the Global Physical Activity Questionnaire. Psychological distress was assessed using the General Health Questionnaire 30. Mixed-effects modeling was performed to test associations between psychological distress and changes in sedentary time and physical activity.

Results
The cohort comprised 334 male Japan Self-Defense Forces personnel. The prevalence of psychological distress after deployment was 12.6%. The interaction of sedentary time and time was significantly associated with a greater psychological distress risk. Psychological distress was greater when sedentary time showed a large increase than when sedentary time showed less change during deployment. A greater increase in work-related physical activity from before to during deployment was associated with decreased psychological distress.

Conclusions
These findings suggest that a greater increase in sedentary time from before deployment to during deployment is associated with increased psychological distress after deployment. Healthcare professionals should recommend reducing sedentary time to improve mental health, especially after overseas deployments.
Surgical approach to management of oroantral communications. Case report
Authors: Salas Edgar , Ladino Luis Gabriel 
Published: November 2024

Abstract
One of the most frequent post-extraction complications of posterior maxillary teeth is oroantral communication, which consists of direct communication between the maxillary sinus and the oral cavity. The recommendation is to make an immediate closure within the first 48 hours to avoid possible complications that may include an oroantral fistula or chronic sinus disease. Currently, different techniques have been described for closing communication, including various types of materials. Some of the techniques are exclusively oriented toward closure, while others seek to achieve bone regeneration by using bone substitutes for the subsequent placement of dental implants. The aim of this study is to describe a simple surgical technique for managing oroantral communication using a collagen sponge with hydroxyapatite and ribose and covering it with overlapping double layers of ribose cross-linked collagen membrane without fixation.
European Banks and Multilevel Institutional Governance
Authors: Lo Schiavo Gianni 
Published: November 2024

Abstract
This chapter discusses the multilevel institutional governance of banks in the European Union (EU). It begins by looking at the theories behind institutional governance of banks in the EU. The chapter then presents the different levels of EU institutional governance, examining the main actors of EU decision-making and their internal bodies and rules of functioning. The European Banking Union is the most important framework, in which the European Central Bank and the Single Resolution Board play a key role. Meanwhile, there are mainly three institutional actors at the international level: the G-20, the Financial Stability Board, and the Bank of International Settlement, where the Basel Committee on Banking Supervision has the most relevant role for banking regulation. There are also other EU institutions, agencies, and bodies that play a key role in EU banking regulation and supervision, having certain tasks and powers impacting the supranational framework.
New Frontiers in EU Banking Regulation
Authors: Lo Schiavo Gianni 
Published: November 2024

Abstract
This chapter explores some critical areas of banking regulation that can be considered new frontiers, where the supranational EU banking framework shows relevant reform prospects and areas of challenges and opportunities. It begins by discussing the evolution of digital innovation and Fintech as a new form of banking service provision and functioning. The chapter then considers the impact of the ESG (environmental, social, and governance) and the Green Deal EU agenda on banking regulation. It also looks at the main challenges of Brexit from a European banking law and policy perspective and the need to understand the implications of the UK departure for European banks in Europe. Finally, the chapter examines the intersection between EU banking regulation and central banking tasks.
Introduction
Authors: Wood Michael , Sender Omri 
Published: November 2024

Abstract
This introductory chapter recalls that even though the international legal system remains heavily dependent on customary international law, determining the existence and content of customary rules is not always straightforward. It then explains the aim of the present book, which seeks to complement the work of the International Law Commission on ‘Identification of customary international law’ by offering greater detail and analysis for those with the time or need to dig deeper, including in respect of several matters not covered by the Commission’s work. The chapter also explains why there is a need for a rigorous approach to identifying customary international law, and the importance of using accurate terminology. customary international law
Acceptance as Law (Opinio Juris)
Authors: Wood Michael , Sender Omri 
Published: November 2024

Abstract
This chapter considers in detail the constituent element of acceptance as law (opinio juris), discussing its meaning and role in the development and determination of customary international law. The chapter highlights the distinction between acceptance as law and other motives that may underlie a practice. It explains whose acceptance as law is to be ascertained for a practice to be considered a right or obligation under customary international law. It also elaborates on the variety of ways in which acceptance as law may be evidenced, in relation to both States and, where relevant, international organizations. customary international law
The Significance of Treaties for the Identification of Customary International Law
Authors: Wood Michael , Sender Omri 
Published: November 2024

Abstract
This chapter examines the significance of treaties for the identification of customary international law, demonstrating that these two primary sources of international law do not exist in sealed compartments. It explains that a rule set forth in a treaty may sometimes codify, crystallize, or generate a corresponding rule of customary international law, and points to several considerations that need to guide an inquiry into whether this had occurred in any particular case. The chapter also considers the potential significance of a series of similar treaty provisions as evidence of customary international law.customary international law
UniProt: the Universal Protein Knowledgebase in 2025
Authors:   The UniProt Consortium, Bateman Alex , Martin Maria-Jesus , Orchard Sandra , Magrane Michele , Adesina Aduragbemi , Ahmad Shadab , Bowler-Barnett Emily H , Bye-A-Jee Hema , Carpentier David , Denny Paul , Fan Jun , Garmiri Penelope , Gonzales Leonardo Jose da Costa , Hussein Abdulrahman , Ignatchenko Alexandr , Insana Giuseppe , Ishtiaq Rizwan , Joshi Vishal , Jyothi Dushyanth , Kandasaamy Swaathi , Lock Antonia , Luciani Aurelien , Luo Jie , Lussi Yvonne , Marin Juan Sebastian Martinez , Raposo Pedro , Rice Daniel L , Santos Rafael , Speretta Elena , Stephenson James , Totoo Prabhat , Tyagi Nidhi , Urakova Nadya , Vasudev Preethi , Warner Kate , Wijerathne Supun , Yu Conny Wing-Heng , Zaru Rossana , Bridge Alan J , Aimo Lucila , Argoud-Puy Ghislaine , Auchincloss Andrea H , Axelsen Kristian B , Bansal Parit , Baratin Delphine , Batista Neto Teresa M , Blatter Marie-Claude , Bolleman Jerven T , Boutet Emmanuel , Breuza Lionel , Gil Blanca Cabrera , Casals-Casas Cristina , Echioukh Kamal Chikh , Coudert Elisabeth , Cuche Beatrice , de Castro Edouard , Estreicher Anne , Famiglietti Maria L , Feuermann Marc , Gasteiger Elisabeth , Gaudet Pascale , Gehant Sebastien , Gerritsen Vivienne , Gos Arnaud , Gruaz Nadine , Hulo Chantal , Hyka-Nouspikel Nevila , Jungo Florence , Kerhornou Arnaud , Mercier Philippe Le , Lieberherr Damien , Masson Patrick , Morgat Anne , Paesano Salvo , Pedruzzi Ivo , Pilbout Sandrine , Pourcel Lucille , Poux Sylvain , Pozzato Monica , Pruess Manuela , Redaschi Nicole , Rivoire Catherine , Sigrist Christian J A , Sonesson Karin , Sundaram Shyamala , Sveshnikova Anastasia , Wu Cathy H , Arighi Cecilia N , Chen Chuming , Chen Yongxing , Huang Hongzhan , Laiho Kati , Lehvaslaiho Minna , McGarvey Peter , Natale Darren A , Ross Karen , Vinayaka C R , Wang Yuqi , Zhang Jian 
Published: November 2024

Abstract
The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication, we describe ongoing changes to our production pipeline to limit the sequences available in UniProtKB to high-quality, non-redundant reference proteomes. We continue to manually curate the scientific literature to add the latest functional data and use machine learning techniques. We also encourage community curation to ensure key publications are not missed. We provide an update on the automatic annotation methods used by UniProtKB to predict information for unreviewed entries describing unstudied proteins. Finally, updates to the UniProt website are described, including a new tab linking protein to genomic information. In recognition of its value to the scientific community, the UniProt database has been awarded Global Core Biodata Resource status.
Watch-and-wait approach versus adjuvant treatment after radical awake resection in selected adult-type grade 3 gliomas, isocitrate dehydrogenase mutant: A case-matched cohort
Authors: Elia Angela , Roux Alexandre , Trancart Bénédicte , Moiraghi Alessandro , Seneca Maimiti , Dezamis Edouard , Varlet Pascale , Chretien Fabrice , Oppenheim Catherine , Zanello Marc , Pallud Johan 
Published: November 2024

Abstract

Background
Following large resection, proposing a watch-and-wait strategy in selected grade 3 glioma, isocitrate dehydrogenase (IDH)-mutant patients is an emerging practice. We compared the watch-and-wait approach to the standard postoperative adjuvant oncological treatment for grade 3 gliomas, IDH-mutant.

Methods
Observational, retrospective, single-institution cohort (2011–2023) of 106 consecutive adult patients harboring supratentorial grade 3 gliomas, IDH-mutant treated by maximal awake resection and who received a watch-and-wait approach (surgery group) or an adjuvant oncological treatment (oncological group) postoperatively. Case-matched analysis (1:1) criteria between the surgery group and oncological group: extent of resection, tumor volume, Karnofsky Performance Status (KPS) score, tumor location and size, and age.

Results
Patients of the surgery group (n = 26) had significantly better KPS scores, less preoperative neurological and/or neurocognitive deficits, less hyperperfusion, less corpus callosum infiltration, smaller tumor volume, higher rate of total resection, and smaller residual tumor than patients of the oncological group (n = 80). The 5-year progression-free survival (66.2 vs. 77.9 months, P = .713) and the 5-year overall survival (88.9 vs. 83.9 months, P = .291) did not differ between surgery and oncological groups. In the whole series, a preoperative KPS score &gt;70, a total resection, and the oligodendroglioma subtype were independent predictors of longer progression-free survival and overall survival. After case matching, no difference in survival was observed between watch-and-wait and oncological treatment both in astrocytomas (n = 14 per group) and oligodendrogliomas (n = 12 per group).

Conclusions
Watch-and-wait following radical resection appears to be feasible in highly selected grade 3 gliomas, IDH-mutant patients without impairing survival both in astrocytoma and in oligodendroglioma subgroups.
Time-Dependent Evolution And Source Heterogeneities of Ocean Island Basalts From a Weak Plume, São Jorge, Azores
Authors: Marzoli Andrea , Madeira José , Mata João , De Min Angelo , da Silveira Antònio Brum , Youbi Nasrrddine , Silva Pedro , Bertrand Hervé , Chiaradia Massimo , Jourdan Fred , Meyzen Christine M , Callegaro Sara 
Published: November 2024

Abstract
The geochemical composition of ocean island basalts (OIBs) from the Azores (AZ) reflects the spatial distribution, shape and temporal evolution of small-scale geochemical heterogeneities within their mantle plume source. Here, we investigate the time-related evolution of volcanism at São Jorge Island, Central AZ. New field observations, a magnetic survey, 40Ar/39Ar and 14C ages and geochemical data indicate that the fissural volcanic activity at São Jorge produced at least four main mafic volcanic complexes (V. C.). The oldest V. C., São João, produced the thickest lava piles at ca. 1.3 Ma in the eastern part of the island. After a period of quiescence, the Serra do Topo V. C. was produced at ca. 0.8–0.5 Ma in the central part of the island. The Rosais V. C. was emplaced between ca. 0.4 and 0.1 Ma on the entire island. Finally, the Holocene Manadas V.C. volcanism became active in the western part of the island and includes three historic eruptions (1580, 1808 and 1964 CE).
Magmas were formed at low melting degrees from a peridotitic mantle with possible minor contributions of recycled components. Olivine compositions and whole-rock trace element ratios discard a significant contribution from pyroxenitic source rocks. Melting temperatures (ca. 1420–1480 °C) were slightly higher than those of the ambient upper mantle. The four V.C. are characterized by distinct geochemical compositions in terms of incompatible trace elements and Sr-Nd-Pb isotopic ratios. The oldest V.C., São João, is characterized by Pb isotopic compositions (e.g. markedly negative Δ7/4 and 8/4 values) plotting well below the Northern Hemisphere Reference Line (NHRL). The Upper Pleistocene (Rosais V.C.) lavas from the north-western cliffs have compositions similar to enriched mantle (EM) end-member basalts (e.g. high 207Pb/204Pb at moderate 206Pb/204Pb; high Ba/Nb), which are rare among northern hemisphere OIBs. Finally, high 206Pb/204Pb (up to 20), reflecting contribution from a HIMU-type component characterizes the Holocene Manadas lavas and is occasionally found in lavas from other VCs from 1.3 to 0.1 Ma. These findings indicate that magmas from São Jorge and the nearby Central AZ islands were sourced from a strongly heterogeneous mantle plume, which displayed localized filaments of heterogeneous material that were rapidly exhausted (in ca. 0.2 Ma). The dominant component at São Jorge and in the Central AZ in general appears to be the HIMU-type end-member, which instead is not significant in the Eastern AZ. Possibly, the Central and Eastern AZ were produced by distinct branches of the AZ mantle plume, as would also be consistent with previous tomographic studies.
Does domination require unequal power?
Authors: MacRae Callum Zavos 
Published: November 2024

Abstract
Until recently, many theorists defined domination such that it requires unequal power, and most others held that even if domination were not defined as requiring unequal power, a requirement of unequal power would nevertheless follow from the definition of what domination is. On these views, unless there is an imbalance of power between the two parties, there can be no relation of domination. However, two prominent theorists have recently broken from this consensus, on the grounds that people can depend on one another's arbitrary or uncontrolled wills even in contexts where there is no inequality of power. In this paper, I argue that this is a mistake: domination theorists have a powerful reason to hold that domination cannot take place without a power imbalance. Consequently, we should only accept definitions of the concept on which domination requires unequal power.
The Unidroit Principles of International Commercial Contracts: potential for greater use in the Middle East and North Africa
Authors: Wehling Philine , Mahasneh Nisreen 
Published: November 2024

Abstract
The International Institute for the Unification of Private Law’s (Unidroit) Principles of International Commercial Contracts (UPICC) provide a uniform international instrument setting out general rules for international commercial contracts as an alternative to the State law-centred approach to contracting and dispute resolution. While the UPICC are well known among academics and frequently referred to in practice in many regions of the world including Europe, Latin America, and Asia, they are applied far less often in the Middle East and North Africa (MENA). This is in spite of the fact that their use appears to be widely permissible under MENA States’ domestic legislation, and international trade involvement provides opportunities for them to be applied productively. The reasons for less usage in the MENA region are manifold and include, among others, a judicial tendency to apply domestic law, the hierarchy between the Islamic Sharia and lex mercatoria, the limited involvement of experts from the MENA region in the elaboration of the UPICC and their subsequent promotion, and limited linguistic accessibility. Potential advantages of greater usage include the promotion of fair and harmonized contract practices and facilitating the resolution of cross-border private legal conflicts as well as the UPICC’s use as a model and reference for modernization and harmonization of contract law across the region and beyond. This article examines the use of the UPICC in MENA and the potential for facilitating their future impact in the region, focusing on Arab jurisdictions influenced by Islamic law.
Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes
Authors: Lawrence Ben M. , O'Donnell Liza , Gannon Anne‐Louise , Smith Sarah , Curley Michael K. , Darbey Annalucia , Mackay Rosa , O'Shaughnessy Peter J. , Smith Lee B. , Rebourcet Diane 
Published: November 2024

AbstractTestosterone and dihydrotestosterone (DHT) are essential for male development and fertility. In the canonical androgen production pathway, testosterone is produced in the testis by HSD17B3; however, adult male Hsd17b3 knockout (KO) mice continue to produce androgens and are fertile, indicating compensatory mechanisms exist. A second, alternate pathway produces DHT from precursors other than testosterone via 5α‐reductase (SRD5A) activity. We hypothesized that the alternate pathway contributes to androgen bioactivity in Hsd17b3 KO mice. To investigate contributions arising from and interactions between the canonical and alternate pathways, we pharmacologically inhibited SRD5A and ablated Srd5a1 (the predominant SRD5A in the testis) on the background of Hsd17b3 KO mice. Mice with perturbation of either the canonical or both pathways exhibited increased LH, testicular steroidogenic enzyme expression, and normal reproductive tracts and fertility. In the circulation, alternate pathway steroids were increased in the absence of HSD17B3 but were reduced by co‐inhibition of SRD5A1. Mice with perturbations of both pathways produced normal basal levels of intratesticular testosterone, suggesting the action of other unidentified hydroxysteroid dehydrogenase(s). Strikingly, testicular expression of another SRD5A enzyme, Srd5a2, was markedly increased in the absence of Hsd17b3, suggesting a compensatory increase in SRD5A2 to maintain androgen bioactivity during HSD17B3 deficiency. Finally, we observed elevated circulating concentrations of the 11‐keto‐derivative of DHT, suggesting compensatory extra‐gonadal induction of bioactive 11‐keto androgen production. Taken together, we conclude that, in the absence of the canonical pathway of androgen production, multiple intra‐ and extra‐gonadal mechanisms cooperate to maintain testosterone and DHT production, supporting male development and fertility.
Biomarkers in the diagnosis of mast cell activation
Authors: Voelker Dayne , Pongdee Thanai 
Published: November 2024

Purpose of review
Mast cell activation is defined by activation of mast cells by varying stimuli with release of chemical mediators either through degranulation or release of de novo synthesized proteins or lipid mediators. Currently, tryptase measurement increase during symptomatic episodes is the most accepted biomarker measurement for mast cell activation. However, newer diagnostic tools including clinically available urinary mast cell mediators are noninvasive and can be more readily obtained compared to serum tryptase levels. This review will highlight biomarker measurement in the diagnosis of mast cell activation.

Recent findings
This review will highlight biomarker measurement in mast cell activation including serum tryptase and urinary mast cell mediators including N-methylhistamine, leukotriene E4, and 2,3-dinor-11beta-prostaglandin F2 alpha.

Summary
Urine mast cell mediators obtained at baseline and during symptom exacerbation are emerging biomarkers in the diagnosis of mast cell activation. Tryptase measurement and urinary mast cell mediator measurement are currently the most accepted biomarkers for mast cell activation. Further research is needed to establish new biomarkers for mast cell activation.