bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Part Consolidation for Minimum Production Costs and Time Using Additive Manufacturing
Authors: Nie Zhenguo , Jung Sangjin , Kara Levent Burak , Whitefoot Kate S. 
Published: October 2019

AbstractThis research presents a method of optimizing the consolidation of parts in an assembly using metal additive manufacturing (MAM). The method generates candidates for consolidation, filters them for feasibility and structural redundancy, finds the optimal build layout of the parts, and optimizes which parts to consolidate using a genetic algorithm. Results are presented for both minimal production time and minimal production costs, respectively. The production time and cost models consider each step of the manufacturing process, including MAM build, post-processing steps such as support structure removal, and assembly. It accounts for costs affected by part consolidation, including machine costs, material, scrap, energy consumption, and labor requirements. We find that developing a closed-loop filter that excludes consolidation candidates that are structurally redundant with others dramatically reduces the number of candidates, thereby significantly reducing convergence time. Results show that when increasing the number of parts that are consolidated, the production cost and time at first decrease due to reduced assembly steps, and then increase due to additional support structures needed to uphold the larger, consolidated parts. We present a rationale and evidence justifying that this is an important tradeoff of part consolidation that generalizes to many types of assemblies. Subsystems that are smaller, or can be oriented with very little support structures or have low material costs or fast deposition rates can have an optimum at full consolidation; for other subsystems, the optimum is less than 100%. The presented method offers a promising pathway to minimize production time and cost by consolidating parts using MAM. In our test-bed results for an aircraft fairing produced with powder-bed electron beam melting, the solution for minimizing production cost (time) is to consolidate 17 components into four (two) discrete parts, which leads to a 20% (25%) reduction in unit production cost (time).
Modeling Physiological Flow in Fontan Models With Four-Dimensional Flow Magnetic Resonance Imaging, Particle Image Velocimetry, and Arterial Spin Labeling
Authors: Rutkowski David R. , Medero Rafael , Ruesink Timothy A. , Roldán-Alzate Alejandro 
Published: October 2019

Abstract
The Fontan procedure is a successful palliation for single ventricle defect. Yet, a number of complications still occur in Fontan patients due to abnormal blood flow dynamics, necessitating improved flow analysis and treatment methods. Phase-contrast magnetic resonance imaging (MRI) has emerged as a suitable method for such flow analysis. However, limitations on altering physiological blood flow conditions in the patient while in the MRI bore inhibit experimental investigation of a variety of factors that contribute to impaired cardiovascular health in these patients. Furthermore, resolution and flow regime limitations in phase contrast (PC) MRI pose a challenge for accurate and consistent flow characterization. In this study, patient-specific physical models were created based on nine Fontan geometries and MRI experiments mimicking low- and high-flow conditions, as well as steady and pulsatile flow, were conducted. Additionally, a particle image velocimetry (PIV)-compatible Fontan model was created and flow was analyzed with PIV, arterial spin labeling (ASL), and four-dimensional (4D) flow MRI. Differences, though nonstatistically significant, were observed between flow conditions and between patient-specific models. Large between-model variation supported the need for further improvement for patient-specific modeling on each unique Fontan anatomical configuration. Furthermore, high-resolution PIV and flow-tracking ASL data provided flow information that was not obtainable with 4D flow MRI alone.
Machine Learning-Based Design Concept Evaluation
Authors: Camburn Bradley , He Yuejun , Raviselvam Sujithra , Luo Jianxi , Wood Kristin 
Published: October 2019

AbstractIn order to develop novel solutions for complex systems and in increasingly competitive markets, it may be advantageous to generate large numbers of design concepts and then to identify the most novel and valuable ideas. However, it can be difficult to process, review, and assess thousands of design concepts. Based on this need, we develop and demonstrate an automated method for design concept assessment. In the method, machine learning technologies are first applied to extract ontological data from design concepts. Then, a filtering strategy and quantitative metrics are introduced that enable creativity rating based on the ontological data. This method is tested empirically. Design concepts are crowd-generated for a variety of actual industry design problems/opportunities. Over 4000 design concepts were generated by humans for assessment. Empirical evaluation assesses: (1) correspondence of the automated ratings with human creativity ratings; (2) whether concepts selected using the method are highly scored by another set of crowd raters; and finally (3) if high scoring designs have a positive correlation or relationship to industrial technology development. The method provides a possible avenue to rate design concepts deterministically. A highlight is that a subset of designs selected automatically out of a large set of candidates was scored higher than a subset selected by humans when evaluated by a set of third-party raters. The results hint at bias in human design concept selection and encourage further study in this topic.
Universal Feedback Controllers and Inverse Optimality for Nonlinear Stochastic Systems
Authors: Haddad Wassim M. , Jin Xu 
Published: October 2019

Abstract
In this paper, we develop a constructive finite time stabilizing feedback control law for stochastic dynamical systems driven by Wiener processes based on the existence of a stochastic control Lyapunov function. In addition, we present necessary and sufficient conditions for continuity of such controllers. Moreover, using stochastic control Lyapunov functions, we construct a universal inverse optimal feedback control law for nonlinear stochastic dynamical systems that possess guaranteed gain and sector margins. An illustrative numerical example involving the control of thermoacoustic instabilities in combustion processes is presented to demonstrate the efficacy of the proposed framework.
Measurement of the Thermal Performance of a Custom-Build Single-Phase Immersion Cooled Server at Various High and Low Temperatures for Prolonged Time
Authors: Bansode Pratik V. , Shah Jimil M. , Gupta Gautam , Agonafer Dereje , Patel Harsh , Roe David , Tufty Rick 
Published: October 2019

Abstract
The next radical change in the thermal management of data centers is to shift from conventional cooling methods like air-cooling to direct liquid cooling to enable high thermal mass and corresponding superior cooling. There has been in the past few years a limited adoption of direct liquid cooling in data centers because of its simplicity and high heat dissipation capacity. Single-phase engineered fluid immersion cooling has several other benefits like better server performance, even temperature profile, and higher rack densities and the ability to cool all components in a server without the need for electrical isolation. The reliability aspect of such cooling technology has not been well addressed in the open literature. This paper presents the performance of a fully single-phase dielectric fluid immersed server over wide temperature ranges in an environmental chamber. The server was placed in an environmental chamber and applied extreme temperatures ranging from −20 °C to 10 °C at 100% relative humidity and from 20 to 55 °C at constant 50% relative humidity for extended durations. This work is a first attempt of measuring the performance of a server and other components like pump including flow rate drop, starting trouble, and other potential issues under extreme climatic conditions for a completely liquid-submerged system. Pumping power consumption is directly proportional to the operating cost of a data center. The experiment was carried out until the core temperature reached the maximum junction temperature. This experiment helps to determine the threshold capacity and the robustness of the server for its applications in extreme climatic conditions.
Impact of Aging on Mechanical Properties of Thermally Conductive Gap Fillers
Authors: Misrak Abel , Chauhan Tushar , Rajmane Pavan , Bhandari Rabin , Agonafer Dereje 
Published: October 2019

Abstract
Thermal interface materials (TIMs) are an important component in electronic packaging, and there is a concerted effort to understand their reliability when used under various environmental load conditions. Previous researchers have investigated gap fillers and other types of TIMs to understand their performance degradation under loading conditions such as thermal cycling and thermal aging. Most of the study in the literature focuses on studying the changes in thermal properties, and there is a lack of understanding when it comes to studying the mechanical behavior of TIMs. Degradation of mechanical properties is the cause for the loss in thermal performance and is critical during TIM selection process. Moreover, mechanical properties such as modulus and coefficient of thermal expansion (CTE) are critical to assess performance of TIMs using finite element analysis (FEA) and potentially save time and money in the evaluation and selection process. Due to the very soft nature of TIMs, sample preparation is a challenging part of material characterization. In this paper, commercially available TIMs are studied using testing methods such as thermomechanical analyzer (TMA), dynamic mechanical analyzer (DMA), and Fourier infrared spectroscopy (FTIR). These methods are used to characterize the material properties and study the changes in properties due to aging. In this work, the followings are presented: impact of filler content on the mechanical properties, sample preparation method for curable TIM materials with specified thicknesses, and impact of thermal aging on mechanical properties.
Supervising the supervisors: What support do first-line supervisors need to be more effective in their supervisory role?
Authors: Patterson Frances 
Published: October 2019

INTRODUCTION: Stepping into a supervisory role in social work involves a shift of status, perspective and identity. New supervisors bring skills and experience which can be both asset and hindrance as they make the transition. Frequently they encounter gaps in training, support and supervision as well as dissonance between espoused policy and their own experience. This article identifies ways in which supervisors can be resourced to meet the challenge of their role and, as a result, be better placed to support others. It explores what is involved in supervising the supervisors, drawing on the experience of teaching managers on post-qualifying courses in professional supervision in Scotland.APPROACH: Themes commonly applied to the supervision of practitioners are explored in relation to those who are one or more steps removed from direct practice; seeking to identify what has shared relevance and what may be distinctive to those in a supervisory role.CONCLUSION: A congruent approach to support and supervision across all levels of an organisation helps foster a reflective culture which can engage with emotions and with complexity.
Registered social workers who are supervisors: A national survey
Authors: O’Donoghue Kieran B. 
Published: October 2019

INTRODUCTION: Aotearoa New Zealand registered social workers who supervise are expected to provide supervision in accordance with the Social Workers Registration Board standards. This article aims to establish baseline about supervisors and their supervision.METHODS: A national postal survey of 278 registered social workers supervision gathered data about the background, experiences and views of 138 supervisors. The quantitative data were analysed using IBM SPSS 24. One-way ANOVA and post hoc tests were applied to explore variances in means for the independent variables of type of registration, area of practice, gender, age, ethnic identity, sexual orientation, recognised qualifications, experience as social worker, experience as a supervisor, and supervisory training and education across six scales concerned with the respondents’ provision of supervision.FINDINGS: The findings provide baseline demographic information about the supervisors, as well as descriptions of their supervisory practice. This includes information regarding the forms, logistics, types of contact, the approaches and models used, session processes and their overall satisfaction and evaluation of the supervision they provide.CONCLUSIONS: The article concludes that most supervisors provided supervision that is typical of individual, clinical or professional supervision and was aligned with professional standards. Questions were raised concerning the predominance of non-Māori supervisors and the cultural relevancy, safety and responsiveness of supervisors to Māori. Suggestions are made regarding the development of the supervisory workforce. Areas for further research are identified regarding the differences in supervisory practice related to fields of practice, ethnicity, experience, qualifications and training.
A systematic review of non-trunk basilar perforator aneurysms: is it worth chasing the small fish?
Authors: Granja Manuel F , Monteiro Andre , Agnoletto Guilherme Jose , Jamal Sara , Sauvageau Eric , Aghaebrahim Amin , Hanel Ricardo 
Published: October 2019

Background and purposeNon-trunk basilar artery perforator aneurysms (BAPAs) are rare intracranial vascular pathologies that have long been underdiagnosed, under-reported, and under-analyzed. We performed a systematic review of the efficacy and safety endpoints between conservative and active treatment approaches for non-trunk BAPAs.MethodsMajor databases were analyzed for relevant publications between 1995 and 2019. Studies comparing the outcomes between conservative and active treatment approaches such as coiling, stenting, clipping, liquid embolization, and flow diversion were included. Mortality rate, rate of permanent neurological deficit as determined by the modified Rankin Score (mRS), rate of second treatment occurrence, and perioperative complication rate were also assessed.ResultsA total of 24 studies, including 54 patients with 56 non-trunk BAPAs, were included. The mean maximum aneurysm diameter was 2.70 mm (range 1–10). A diagnosis was achieved with the initial DSA in 50.0% (27/54) of the patients. A conservative approach was used in 16 patients while active treatment was used in the other 38. Thirteen of 15 (86.7%) patients in the conservative group and 27/34 (79.4%) in the active treatment group had an mRS score 0–2. A non-significant higher odds of a positive outcome was observed in the conservative group (OR 1.51, 95% CI 0.50 to 4.54). The event-related mortality rate was 3.55% (3/54) with one procedure-related death in the active treatment group.ConclusionsIn patients with non-trunk BAPAs unamenable to active treatment, conservative approaches may result in acceptable functional outcomes and low morbidity. Small sample sizes and under-reporting of outcomes warrant further study.
Exponential Separations in the Energy Complexity of Leader Election
Authors: Chang Yi-Jun , Kopelowitz Tsvi , Pettie Seth , Wang Ruosong , Zhan Wei 
Published: October 2019

Energy
is often the most constrained resource for battery-powered wireless devices, and most of the energy is often spent on
transceiver usage
(i.e., transmitting and receiving packets) rather than computation. In this article, we study the
energy complexity
of fundamental problems in several models of wireless radio networks. It turns out that energy complexity is very sensitive to whether the devices can generate random bits and their ability to
detect collisions
. We consider four collision detection models: Strong-CD (in which transmitters and listeners detect collisions), Sender-CD (in which only transmitters detect collisions), Receiver-CD (in which only listeners detect collisions), and No-CD (in which no one detects collisions).

The take-away message of our results is quite surprising. For randomized algorithms, there is an exponential gap between the energy complexity of Sender-CD and Receiver-CD:
Randomized: No-CD = Sender-CD > Receiver-CD = Strong-CD

and for deterministic algorithms, there is another exponential gap in energy complexity,
but in the reverse direction
:

Deterministic: No-CD = Receiver-CD > Sender-CD = Strong-CD

Precisely, the randomized energy complexity of Leader Election is Θ(log
*
n
) in Sender-CD but Θ(log(log
*
n
)) in Receiver-CD, where
n
is the number of devices, which is unknown to the devices at the beginning; the deterministic complexity of Leader Election is Θ(log
N
) in Receiver-CD but Θ(log log
N
) in Sender-CD, where
N
is the size of the ID space.

There is a tradeoff between time and energy. We provide a new upper bound on the time-energy tradeoff curve for randomized algorithms. A critical component of this algorithm is a new deterministic Leader Election algorithm for
dense
instances, when
n
= Θ(
N
), with inverse Ackermann energy complexity.
Heavy Hitters and the Structure of Local Privacy
Authors: Bun Mark , Nelson Jelani , Stemmer Uri 
Published: October 2019

We present a new locally differentially private algorithm for the heavy hitters problem that achieves optimal worst-case error as a function of all standardly considered parameters. Prior work obtained error rates that depend optimally on the number of users, the size of the domain, and the privacy parameter but depend sub-optimally on the failure probability.
We strengthen existing lower bounds on the error to incorporate the failure probability and show that our new upper bound is tight with respect to this parameter as well. Our lower bound is based on a new understanding of the structure of locally private protocols. We further develop these ideas to obtain the following general results beyond heavy hitters.

•
Advanced Grouposition
: In the local model, group privacy for
k
users degrades proportionally to ≈√
k
instead of linearly in
k
as in the central model. Stronger group privacy yields improved max-information guarantees, as well as stronger lower bounds (via “packing arguments”), over the central model.

• Building on a transformation of Bassily and Smith (STOC 2015), we give a generic transformation from any non-interactive approximate-private local protocol into a pure-private local protocol. Again in contrast with the central model, this shows that we cannot obtain more accurate algorithms by moving from pure to approximate local privacy.
Metformin Abrogates Age-Associated Ovarian Fibrosis
Authors: McCloskey Curtis W. , Cook David P. , Kelly Brendan S. , Azzi Feryel , Allen Christian H. , Forsyth Amanda , Upham Jeremy , Rayner Katey J. , Gray Douglas A. , Boyd Robert W. , Murugkar Sangeeta , Lo Bryan , Trudel Dominique , Senterman Mary K. , Vanderhyden Barbara C. 
Published: October 2019

AbstractPurpose:The ovarian cancer risk factors of age and ovulation are curious because ovarian cancer incidence increases in postmenopausal women, long after ovulations have ceased. To determine how age and ovulation underlie ovarian cancer risk, we assessed the effects of these risk factors on the ovarian microenvironment.Experimental Design:Aged C57/lcrfa mice (0–33 months old) were generated to assess the aged ovarian microenvironment. To expand our findings into human aging, we assembled a cohort of normal human ovaries (n = 18, 21–71 years old). To validate our findings, an independent cohort of normal human ovaries was assembled (n = 9, 41–82 years old).Results:We first validated the presence of age-associated murine ovarian fibrosis. Using interdisciplinary methodologies, we provide novel evidence that ovarian fibrosis also develops in human postmenopausal ovaries across two independent cohorts (n = 27). Fibrotic ovaries have an increased CD206+:CD68+ cell ratio, CD8+ T-cell infiltration, and profibrotic DPP4+αSMA+ fibroblasts. Metformin use was associated with attenuated CD8+ T-cell infiltration and reduced CD206+:CD68+ cell ratio.Conclusions:These data support a novel hypothesis that unifies the primary nonhereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a premetastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis.See related commentary by Madariaga et al., p. 523
Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models
Authors: Kamoun Walid S. , Dugast Anne-Sophie , Suchy James J. , Grabow Stephanie , Fulton Ross B. , Sampson James F. , Luus Lia , Santiago Michael , Koshkaryev Alexander , Sun Gang , Askoxylakis Vasileios , Tam Eric , Huang Zhaohua Richard , Drummond Daryl C. , Sawyer Andrew J. 
Published: October 2019

Abstract
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here, we present a study on the combination activity and mechanistic rationale of a novel EphA2-targeted liposomal taxane (EphA2-ILs-DTXp) and anti–PD-1. This combination was highly active in mouse syngeneic tumor models, with complete responses observed in 3 of 5 models. In the EMT-6 tumor model, combination of EphA2-ILs-DTXp with anti–PD-1 resulted in a 60% complete response rate, with durable responses that were resistant to rechallenge. These responses were not observed in the absence of CD8+ T cells. Characterization of the immune infiltrates in EMT-6 tumors reveals increased CD8+ T cells, increased CD8+ IFNγ+ CTLs, and an increased CD8/regulatory T-cell (Treg) ratio. These immunomodulatory effects were not observed in mice treated with a combination of docetaxel and anti–PD-1. Pharmacokinetic analysis revealed that the AUC of docetaxel was increased 15 times, from 52.1 to 785 ng/mL/hour, when delivered by EphA2-ILs-DTXp. A dose reduction study of EphA2-ILs-DTXp showed a dose–response relationship for both tumor growth inhibition and the CD8/Treg ratio. Our data indicate that synergism between docetaxel and anti–PD-1 is achievable with nanoliposomal delivery.