bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of antenatal care on low birth weight prevention in Lao PDR: A case control study
Authors: Oulay Latsamy , Laohasiriwong Wongsa , Phajan Teerasak , Assana Supat , Suwannaphant Kritkantorn 
Published: July 2018

Background: Low Birth Weight (LBW) is a worldwide public health problem, which subsequently may affect the health status of the child. Lao PDR has high incidence of LBW. Antenatal care (ANC) is provided to improve maternal and child health outcomes. The aim of this study was to identify the effect ANC on LBW prevention in Lao PDR. Methods: This case control study was conducted in tertiary hospitals of Lao PDR. The ratio of case: control was 1:3, of which there were 52 cases and 156 controls that passed the inclusion criteria included in the study. In our analysis information on pregnancy and ANC including height of mother, maternal weight gain during pregnancy, maternal gestational age at delivery, type of delivery, supplementary vitamins, and other covariates including age, marital status, educational attainment, occupation, family income, health insurance, family size and living condition were described and determine their association with LBW using multiple logistic regression analysis. Results: There were only 32.69 % of complete ANC among cases and 57.69% in control. Incomplete ANC (<4 times) were significant increased the odds of having LBW (adj. OR=2.97; 95%CI: 1.48 to 5.93; p-value =0.002). Other covariates which also influenced LBW were having maternal weight gain during pregnancy less than 10 kg. (adj.OR=2.28; 95%CI: 1.16 to 4.49; p-value = 0.017), maternal gestation age at delivery less than 40 weeks (adj. OR=3.33; 95%CI: 1.52 to 7.32; p-value =0.003). Conclusion: Complete ANC could help both mother and child in term of weight gain and full term delivery which may effect on LBW reduction.
Osteogenic potential of gingival stromal progenitor cells cultured in platelet rich fibrin is predicted by core-binding factor subunit-α1/Sox9 expression ratio (in vitro)
Authors: Nugraha Alexander Patera , Narmada Ida Bagus , Ernawati Diah Savitri , Dinaryanti Aristika , Hendrianto Eryk , Ihsan Igo Syaiful , Riawan Wibi , Rantam Fedik Abdul 
Published: July 2018

Background:Alveolar bone defect regeneration has long been problematic in the field of dentistry. Gingival stromal progenitor cells (GSPCs) offer a promising solution for alveolar bone regeneration. In order to optimally differentiate and proliferate progenitor cells, growth factors (GFs) are required. Platelet rich fibrin (PRF) has many GFs and can be easily manufactured. Core-binding factor subunit-α1 (CBF-α1) constitutes a well-known osteogenic differentiation transcription factor in SPCs. Sox9, as a chondrogenic transcription factor, interacts and inhibits CBF-α1, but its precise role in directin vitroosteogenesis remains unknown. GSPCs culturedin vitroin PRF to optimally stimulate osteogenic differentiation has been largely overlooked. The aim of this study was to analyze GSPCs cultured in PRF osteogenic differentiation predicted by CBF-α1/Sox9.Methods: This study used a true experimental with post-test only control group design and random sampling. GPSCs isolated from the lower gingiva of four healthy, 250-gram, 1-month old, male Wistar rats (Rattus Novergicus) were cultured for two weeks, passaged every 4-5 days. GSPCs in passage 3-5 were cultured in five M24 plates (N=108; n=6/group) for Day 7, Day 14, and Day 21 in three different mediums (control negative group: αModified Eagle Medium; control positive group: High Glucose-Dulbecco’s Modified Eagle Medium (DMEM-HG) + osteogenic medium; Treatment group: DMEM-HG + osteogenic medium + PRF). CBF-α1 and Sox9 were examined with ICC monoclonal antibody. A one-way ANOVA continued with Tukey HSD test (p<0.05) based on Kolmogorov–Smirnov and Levene's tests (p>0.05) was performed.Results:The treatment group showed the highest CBF-α1/Sox9 ratio (16.00±3.000/14.33±2.517) on Day 7, while the lowest CBF-α1/Sox9 ratio (3.33±1.528/3.67±1.155) occurred in the control negative group on Day 21, with significant difference between the groups (p<0.05).Conclusion:GSPCs cultured in PRF had potential osteogenic differentiation ability predicted by the CBF-α1/sox9 ratio.
Technical Note—Optimal Pricing with Sequential Consumption in Networks
Authors: Zhou Junjie , Chen Ying-Ju 
Published: July 2018

In this paper, we consider a model with a monopoly firm who sells social goods sequentially to a group of customers in a network. We show that, with symmetric social interactions, the optimal pricing under arbitrary launch sequence is independent of customers’ network positions, the launch sequence, and the underlying social interaction relations among customers. This generalizes the previous network-independent prices in the simultaneous-launch case. Therefore, for any given sequence, the firm can obtain a higher profit by offering sequentially to some groups of simultaneous-move customers. As a consequence, the optimal sequence turns out to be a chain structure. Moreover, we establish the pecking order by which the firm shall approach customers following the sequence of descending valuation-cost margins, and with homogeneous margins any chain attains the optimal revenue. The sequence independence of the optimal pricing does not hold when either the social interaction is asymmetric or the firm is restricted to use uniform pricing. Nevertheless, the profit optimality of the chain structure extends to both variants of the basic model. The e-companion is available at https://doi.org/10.1287/opre.2018.1726 .
Dignity therapy interventions for young people in palliative care: a rapid structured evidence review
Authors: Rodriguez Alison , Smith Joanna , McDermid Kirstine 
Published: July 2018

Background: Dignity therapy is becoming established in adult settings, with research supporting its effectiveness. Aims: This article aims to summarise and synthesise the research that has explored dignity therapy and related meaning-making interventions in palliative care with young people. Methods: A rapid structured review was undertaken. Quality appraisal was based on the randomised control trial or cohort study Critical Appraisals Skills Programme (CASP) tool. Results: Four studies met the inclusion criteria; one focused on young people (7–17 years), the other three included young people but mean ages were 50–70 years. Dignity therapy was found to improve aspects of wellbeing for the patient and was perceived as helpful for the family. Conclusions: Dignity therapy is well received, with improvements in measures of wellbeing. However, few studies have included young people (24 years and below). This highlights a clear gap in the literature, suggesting the need to develop and evaluate a dignity therapy or related meaning-making intervention to support young people.
A retrieval analysis of the Precice intramedullary limb lengthening system
Authors: Panagiotopoulou V. C. , Davda K. , Hothi H. S. , Henckel J. , Cerquiglini A. , Goodier W. D. , Skinner J. , Hart A. , Calder P. R. 
Published: July 2018

ObjectivesThe Precice nail is the latest intramedullary lengthening nail with excellent early outcomes. Implant complications have led to modification of the nail design. The aim of this study was to perform a retrieval study of Precice nails following lower-limb lengthening and to assess macroscopical and microscopical changes to the implants and evaluate differences following design modification, with the aim of identifying potential surgical, implant, and patient risk factors.MethodsA total of 15 nails were retrieved from 13 patients following lower-limb lengthening. Macroscopical and microscopical surface damage to the nails were identified. Further analysis included radiology and micro-CT prior to sectioning. The internal mechanism was then analyzed with scanning electron microscopy and energy dispersive x-ray spectroscopy to identify corrosion.ResultsSeven male and three female patients underwent 12 femoral lengthenings. Three female patients underwent tibial lengthening. All patients obtained the desired length with no implant failure. Surface degradation was noted on the telescopic part of every nail design, less on the latest implants. Microscopical analysis confirmed fretting and pitting corrosion. Following sectioning, black debris was noted in all implants. The early designs were found to have fractured actuator pins and the pin and bearings showed evidence of corrosive debris. The latest designs showed evidence of biological deposits suggestive of fluid ingress within the nail but no corrosion.ConclusionThis study confirms less internal corrosion following modification, but evidence of titanium debris remains. We recommend no change to current clinical practice. However, potential reuse of the Precice nail, for secondary limb lengthening in the same patient, should be undertaken with caution. Cite this article: V. C. Panagiotopoulou, K. Davda, H. S. Hothi, J. Henckel, A. Cerquiglini, W. D. Goodier, J. Skinner, A. Hart, P. R. Calder. A retrieval analysis of the Precice intramedullary limb lengthening system. Bone Joint Res 2018;7:476–484. DOI: 10.1302/2046-3758.77.BJR-2017-0359.R1.
Personalization 2.0? – Testing the personalization hypothesis in citizens’, journalists’, and politicians’ campaign Twitter communication
Authors: Otto Lukas P. , Glogger Isabella , Maier Michaela 
Published: July 2018

Abstract
This paper advances the research on personalization of political communication by investigating whether this process of focusing on politicians instead of political issues plays a role on Twitter. Results of a content analysis of 5,530 tweets posted in the run-up to the German federal election provide evidence that Twitter communication refers more often to politicians than to issues. However, tweets containing personal characteristics about political leaders play only a marginal role. When distinguishing among different groups of actors on Twitter (journalists, politicians, citizens), we find that citizens focus more on candidates than do journalists or politicians. Investigating the impact of a televised debate on Twitter communication, we observe that this person-centered event puts the focus on individual politicians instead of issues.
Stochastic comparisons and bounds for conditional distributions by using copula properties
Authors: Navarro Jorge , Sordo Miguel A. 
Published: July 2018

Abstract We prove that different conditional distributions can be represented as distorted distributions. These representations are used to obtain stochastic comparisons and bounds for them based on properties of the underlying copula. These properties can be used to explain the meaning of mathematical properties of copulas connecting them with dependence concepts. Some applications and illustrative examples are provided as well.
Biological and medical applications of plasma-activated media, water and solutions
Authors: Kaushik Nagendra Kumar , Ghimire Bhagirath , Li Ying , Adhikari Manish , Veerana Mayura , Kaushik Neha , Jha Nayansi , Adhikari Bhawana , Lee Su-Jae , Masur Kai , von Woedtke Thomas , Weltmann Klaus-Dieter , Choi Eun Ha 
Published: July 2018

Abstract
Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) – the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications. Here, we reviewed promising reports demonstrating plasma-liquid interaction chemistry and the application of PAM or PAW as an anti-cancer, anti-metastatic, antimicrobial, regenerative medicine for blood coagulation and even as a dental treatment agent. We also discuss the role of PAM on cancer initiation cells (spheroids or cancer stem cells), on the epithelial mesenchymal transition (EMT), and when used for metastasis inhibition considering its anticancer effects. The roles of PAW in controlling plant disease, seed decontamination, seed germination and plant growth are also considered in this review. Finally, we emphasize the future prospects of PAM, PAW or plasma-activated solutions in biomedical applications with a discussion of the mechanisms and the stability and safety issues in relation to humans.
Inhibition of JAK2/STAT3 signaling suppresses bone marrow stromal cells proliferation and osteogenic differentiation, and impairs bone defect healing
Authors: Yu Xin , Li Zhi , Wan Qilong , Cheng Xin , Zhang Jing , Pathak Janak L. , Li Zubing 
Published: July 2018

Abstract
Mesenchymal stem cells (MSCs) undergo osteogenic differentiation during bone defect healing. However, the role of JAK2/STAT3 in the osteogenic differentiation of MSCs and bone defect healing is still not fully understood. In this study, we aimed to analyze the effect of AG490, a JAK2-specific inhibitor, on MSCs proliferation and osteogenic differentiation as well as in bone defect healing. We used AG490 to inhibit the JAK2/STAT3 signaling in a mice bone marrow stromal cells (BMSCs) culture. AG490 inhibited BMSCs proliferation and osteogenic differentiation markers, i.e. Col1α, Alp and Ocn expression in mRNA and protein levels. Inhibition of JAK2 reduced ALP activity and matrix mineralization in BMSCs culture. Inhibition of JAK2 reduced phosphorylation of STAT3, AKT, P38, and JNK phosphorylation. Immunohistochemistry showed high numbers of pJAK2, pSTAT3 and ALP positive cells and AG490 reduced this effect in vivo. Histology and μ-computed tomography (CT) data showed that AG490 treatment inhibits bone regeneration and bone defect healing. Our results clearly showed the inhibitory effect of AG490 on proliferation and osteogenic differentiation of BMSCs, bone regeneration and bone defect healing. Moreover, AG490 inhibited phosphorylation of STAT3, P38, JNK and AKT. This suggests the possible role of JAK2/STAT3 signaling in hypoxia-induced osteogenic differentiation of MSCs and bone defect healing.
Red blood cell counts and indices in the elderly German population
Authors: Röhrig Gabriele , Becker Ingrid , Gutensohn Kai , Nebe Thomas 
Published: July 2018

AbstractBackgroundData on peripheral blood cell values in older subjects are rare. While hemoglobin (Hb) values are supposed to change with rising age, little is known about reference values for other erythrocytic blood cell counts. This cross-sectional study was initiated to analyze hematologic laboratory parameters among subjects aged ≥60 years.MethodsThis was a retrospective cross-sectional study of outpatient laboratory data between January 1stand December 31st, 2015 originating from a German countrywide laboratory group; inclusion criteria: age ≥60 years, normal C-reactive protein (CRP), transferrin saturation, reticulocytes, lactate dehydrogenase, haptoglobin and soluble transferrin receptor; exclusion criteria: glomerular filtration rate (GFR)<60 mL/min, lack of inclusion criteria; primary objective: assessment of the mean Hb value; secondary objective: assessment of mean values of red blood cell (RBC) counts.ResultsOf 30,611 subjects ≥60 years, 4641 met the inclusion criteria and were thus considered hematologically healthy; the following age groups were formed: 60–69 years (2094), 70–79 years (2171), 80–89 years (360), >90 years (16); median values for male/female subjects were: Hb 15.2/14.0 g/dL, RBC 5.0/4.6/μL, mean cellular volume (MCV) 89/89/fl, mean corpuscular hemoglobin (MCH) 31/30 pg/RBC, mean corpuscular hemoglobin concentration (MCHC) 34/34 g/dL, hematocrit (hct) 44/41%. Statistical evaluation revealed a slight but significant decrease in values over age decades for all parameters except for MCH. However, all values remained within the recommended German Society of Hematology and Oncology (DGHO) reference ranges. Hb values remained above the recommended World Health Organization (WHO) cut-offs for definition of anemia.ConclusionsThe results confirm the WHO reference values and are in accordance with the recommended DGHO reference values and previous results of other study cohorts outside Germany. There seems to be no need for establishing age-specific RBC or erythrocytic reference ranges for subjects >60 years.
Repetitive transcranial magnetic stimulation in patients with late life depression influences phenylalanine metabolism
Authors: Leblhuber F , Steiner K , Gostner Jm , Fuchs D 
Published: July 2018

Abstract
Repetitive transcranial magnetic stimulation (rTMS) is used to treat different neuropsychiatric conditions like Parkinson’s disease, essential tremor, stroke, cognitive decline, dementia and depression. rTMS may exert its therapeutic effects by influencing the biochemistry of neurotransmitters. In this exploratory study, safety symptom improvement and changes in the availability of neurotransmitter precursor amino acids were studied following prefrontal cortex (PFC) stimulation using repetitive transcranial stimulation with TheraCell apparatus R (Guth Meditec, Salach, Germany) as an additional treatment in ten patients with late life depression. Treatment was well tolerated with no serious adverse effects being observed. rTMS induced a significant improvement in the symptoms of depression and a significant decrease in the HAMD-7 (p <0.03). At the same time, the serum phenylalanine to tyrosine ratio declined significantly (p <0.04). No significant influence of rTMS on tryptophan breakdown and serum neopterin concentrations was observed. These preliminary findings indicate that rTMS may influence the activity of the enzyme phenylalanine hydroxylase (PAH) which plays a key role in the biosynthesis of neurotransmitter precursors related to neuropsychiatric symptoms in late life depression. However, results were obtained from only 10 patients. Larger studies are therefore required to support these conclusions
Planning, Evaluation and Financing of Transport Infrastructures: Rethinking the Basics
Authors: de Rus Ginés , Socorro M. Pilar 
Published: July 2018

AbstractThis paper revises some of the common views on transport infrastructure investment and proposes alternative ways to achieve a more efficient planning, evaluation and financing of transport infrastructures in a world where planners may pursue their own interests, there exist different levels of government, and budget constraints are pervasive. We focus on the need for public planning and independent economic evaluation, and the importance of deciding the pricing scheme in the planning phase. We also discuss the institutional design and its effect on investment decisions, particularly, the financing of projects under different levels of government and its perverse consequences on infrastructure capacity choices. We use as an example the development of the HSR to serve medium-distance trips in corridors where air transport is a very close substitute.
Improvement of delta-endotoxin production from local Bacillus thuringiensis Se13 using Taguchi’s orthogonal array methodology
Authors: Eski Ardahan , Demirbağ Zihni , Demir İsmail 
Published: July 2018

Abstract

Objective
The insecticidal activity of Bacillus thuringiensis directly depends on the yield of delta-endotoxins. In this study, various nutritional and cultural parameters influencing delta-endotoxin synthesis by a local isolate of B. thuringiensis Se13 were investigated using Taguchi methods.

Methods
In the first experiment, four factors, incubation period, incubation temperature, initial pH and medium, each at four levels, were selected and an orthogonal array layout of L16 was carried out. In the second experiment, Taguchi’s orthogonal array method of L27 was used to evaluate the effects of the different concentration of medium components. Taguchi’s signal–noise ratio and variance analysis were applied to determine the effect of the factors. After each experiment, verification studies were carried out using determined optimum conditions.

Results
The optimum conditions for incubation period, incubation temperature, initial pH, and medium determined as 72 h, 30°C, pH 9, and M4 medium, respectively. In the second experiment, soybean flour (5%), glucose (5%), KH2PO4 (0.3%), K2HPO4 (0.1%), MgSO4 (0.4%) were determined as the optimum conditions. The delta-endotoxin yield was elevated to 1559.25 μg mL−1 when the factors were adjusted to optimum level.

Conclusion
Optimization using the Taguchi method appeared to be a good choice for the overproduction of delta-endotoxin.
Pengaruh Loneliness, Self-Control, Dan Self Esteem Terhadap Perilaku Cyberbullying Pada Mahasiswa
Authors: Anwarsyah Fadhli , Gazi Gazi 
Published: July 2018

This research aims to determine the effect of loneliness, self-control, self-esteem against cyberbullying to UIN Syarif Hidayatullah Jakarta student. Researchers used quantitative approach with multiple regression analysis techniques. Population and sample of this research was a UIN Syarif Hidayatullah Jakarta student. The sampling used non-probability technique that involved 261 students. The measuring instrument was adapted from a scale of cyberbullying as a theory Williard, UCLA Loneliness Scale (UCLA-LS), a measuring instrument was adapted from the scale of self-control as a theory Averill, The Rosenberg Self-esteem Scale. The results of this research showed that loneliness of self-control and self-esteem significantly affect cyberbullying with contribution 23%. There are four variables that significantly affect the cyberbullying that trait loneliness, depression, loneliness, cognitive control, and decisional control. While social desirability variable loneliness, behavioral control and self-esteem were not significant. DOI: 10.15408/tazkiya.v22i2.8401
The Effect Of Attachment Style And Religiousity Toward Dating Violence Among Adolescent
Authors: Purnomo Farah Hanifa , Suryadi Bambang , Suryadi Bambang 
Published: July 2018

On adolescence, there are some changes that occur. One of them is emotionally changes that causing the interest feeling with opposite sex emerge. In this era, dating on adolescent is not a new thing. However, the impacts of dating become more serious. One of them is dating violence amongst adolescent couples. The objective of this study is to examine the effect of attachment style, religiousity and gender toward dating violence among adolescent. Samples are 209 students which were taken with convenience technique. The three scales that used in this study are dating violence scale, religiousity scale, and attachment style scale. Their validities are examined by confirmatory factor analysis (CFA). Meanwhile, the method that used is multiple regression. Findings were consistent with previous research. The findings show that religiousity, attachment style and gender has significant effect toward dating violence among adolescent. All of the independent variabels have implication about 10,5%, and the others were affected by variables outside the research. After the proportion variance were analyzed, the results show that fearful avoidant, which is dimension of attachment style, and gender are the biggest predictors toward dating violence. For better result, we suggest to use bigger sample size. DOI: 10.15408/tazkiya.v22i2.8404