bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvements in Back and Leg Pain after Minimally Invasive Lumbar Decompression
Authors: Massel Dustin H. , Mayo Benjamin C. , Patel Dil V. , Bohl Daniel D. , Louie Philip K. , Lopez Gregory D. , Singh Kern 
Published: February 2019

Background Few studies have quantified clinical improvement following minimally invasive lumbar decompression based on predominant back pain or leg pain. Purpose To quantify improvement in patient-reported outcomes following minimally invasive lumbar decompression and determine the degree of improvement in back pain, leg pain, and disability in patients who present with predominant back pain or predominant leg pain. Methods Patients who underwent primary, one-level minimally invasive lumbar decompression for degenerative pathology were retrospectively reviewed. Comparisons of visual analog scale (VAS) back and leg pain scores, Oswestry Disability Index (ODI) scores, and Short Form-12 (SF-12) mental and physical component scores from pre-operative to 6-week, 12-week, 6-month, and 1-year follow-up. Subgroup analyses were performed for patients with predominant back pain or predominant leg pain. Results A total of 102 patients were identified. Scores on VAS back and leg pain, ODI, and SF-12 physical component improved from pre-operative to all post-operative time points. After 1 year, patients reported a 2.8-point (47%) reduction in back pain and a 4-point (61.1%) reduction in leg pain scores; 52 patients with predominant back pain and 50 patients with predominant leg pain reported reductions in pain throughout the year following surgery. In both the back and leg pain cohorts, patients experienced reductions in ODI during the first 6 months and throughout 1-year follow-up, respectively. The majority of patients achieved minimum clinically important difference, regardless of predominant symptom. Conclusions Patients reported improvements in back and leg pain following minimally invasive lumbar decompression regardless of predominant presenting symptom; however, patients with predominant leg pain may experience greater improvement than those with predominant back pain.
Using analytics-driven automation to target the biggest vulnerabilities
Authors: Keef Sean 
Published: February 2019

In 2017, the National Vulnerability Database published 14,000 new Common Vulnerabilities and Exposures (CVEs) – more than double the amount published the previous year. 1 According to mid-year analysis, 2018 is on track to surpass even that record-shattering figure. 2 Organisations using traditional methods to deal with their own massive volumes of vulnerability occurrences will only see problems compound. To deal with vulnerabilities on a scale never seen before, organisations will have to shift to a better, threat-centric approach to vulnerability management. To deal with vulnerabilities on a scale never seen before, organisations need to shift to a better, threat-centric approach to vulnerability management. Threat-centric vulnerability management focuses heavily on intelligently prioritising vulnerabilities by risk rather than severity, analysing vulnerabilities in the context of exposure within the network, potential business impacts and the activity of exploits in the wild. And to do this effectively, especially with the current security skills gap, means automating, argues Sean Keef of Skybox Security.
The Conjugacy Ratio of Groups
Authors: Ciobanu Laura , Cox Charles Garnet , Martino Armando 
Published: February 2019

AbstractIn this paper we introduce and study the conjugacy ratio of a finitely generated group, which is the limit at infinity of the quotient of the conjugacy and standard growth functions. We conjecture that the conjugacy ratio is 0 for all groups except the virtually abelian ones, and confirm this conjecture for certain residually finite groups of subexponential growth, hyperbolic groups, right-angled Artin groups and the lamplighter group.
First evidence of endemic Murinae (Rodentia, Mammalia) in the early Pliocene of the Balearic Islands (western Mediterranean)
Authors: Torres-Roig Enric , Piñero Pedro , Agustí Jordi , Bover Pere , Alcover Josep Antoni 
Published: February 2019

AbstractA new insular species of Paraethomys (Muridae, Rodentia) with medium-sized hypsodont teeth is described from the Zanclean of Mallorca (Balearic Islands, western Mediterranean). The m1 displays the most distinctive traits: hypsodonty, a high occurrence of an unusual anterior cingulum, a well-developed labial cingulum, high accessory labial cuspids resembling the Apodemus pattern and a funnel between c1 and the hypoconid. Paraethomys balearicus sp. nov. preserves traits close to those present in the earliest populations of Paraethomys meini from the upper Turolian, such as a developed posterior spur on t3 in the M1, a connection between t4 and t8 in the M1, a narrow connection between t6 and t9 in the M1 and the occasional presence of an individualized t9 and a t12 in some M2s. The relationship between the new taxon and its direct mainland ancestor gives additional support to a Messinian origin for the so-called Myotragus fauna, which became isolated after the refilling of the Mediterranean Sea 5.33 Ma ago. The absence of Paraethomys in other known younger Mallorcan sites suggests that its extinction most probably occurred at an indeterminate time during the Pliocene Epoch.
The pre-eminent good argument
Authors: BOZZO ALEXANDER 
Published: February 2019

AbstractAccording to J. L. Schellenberg, a perfectly loving God wouldn't permit the occurrence of non-resistant non-believers – that is, non-believers who are both capable of believing in and relating to God, but who fail to believe through no fault of their own. Since non-resistant non-believers exist, says Schellenberg, it follows that God doesn't. A popular response to this argument is some version or other of the greater good defence. God, it's argued, is justified in hiding himself when done for the sake of some greater good. But proponents of this defence have overlooked or neglected an important sub-argument in Schellenberg's case – what I call the ‘pre-eminent good argument’. In this article, I identify the nature of the argument and offer a solution to it.
Complaints about technology as a resource for identity-work
Authors: Robles Jessica S. , Parks Elizabeth S. 
Published: February 2019

AbstractThis article examines how people complain about technology. Using discourse analysis, we inspect sixteen hours of video-recorded focus-group interviews and focused one-on-one discussions where technology was topicalized. We investigate these conversations paying attention to (i) features of language and its situated delivery, including emphasis, word choice, metaphor, and categorizations; and (ii) how these accomplish social actions. We show how interactants use narratives of complaint-like activities about hypothetical categories of people and confessions of their own complainable participation to accomplish a ‘bemoaning’ speech act that manages competing affiliations, demands, and disagreements to construct reasonable moral identities in the situated interaction. By engaging in specific micro-level discursive practices in interaction, participants produce and reproduce what new technologies ‘mean’ to them and for contemporary society. This shows how important it is to examine opinions as situated actions rather than as simple facts about what people believe. (Complaints, accounts, stance, technology, discourse analysis, identity)*
Healthcare: between a human and a conventional right
Authors: Pavel Carmen E. 
Published: February 2019

AbstractOne of the most prevalent rationales for public healthcare policies is a human right to healthcare. Governments are the typical duty-bearers, but they differ vastly in their capacity to help those vulnerable to serious health problems and those with severe disabilities. A right to healthcare is out of the reach of many developing economies that struggle to provide the most basic services to their citizens. If human rights to provision of such goods exist, then governments would be violating rights without doing anything wrong. I argue that such variable ability to provide healthcare depends not only on financial resources, but on institutional capacity, and that the latter represents a more fundamental challenge to the existence of a human right to healthcare than previously recognized. This challenge does not imply that government has no obligations to protect and improve the health of their citizens, but that it is best to think of such obligations as generated by conventional rights, namely rights arising from local legal and social conventions, which require governments to pursue health-related moral goals such as reducing suffering, closing opportunity gaps for the disadvantaged, and preventing the spread of contagious diseases. We need not think of such moral goals in terms of human rights.
High prevalence of selected viruses and parasites and their predictors in Malawian children
Authors: Fan Y.-M. , Oikarinen S. , Lehto K.-M. , Nurminen N. , Juuti R. , Mangani C. , Maleta K. , Hyöty H. , Ashorn P. 
Published: February 2019

AbstractEnteric pathogens have been related to child undernutrition. Whereas there are lots of data on enteric bacterial microbiota and infections, much less is known about the incidence of prevalence of intestinal colonisation with viruses or important parasitic species. This study assessed the presence of selected viruses and parasites in stools of 469, 354, 468 Malawian children at 6, 12 and 18 months. We also assessed environmental predictors of the presence of viruses and parasites among 6-month infants. Microbial presence was documented using real-time polymerase chain reaction (PCR). Enteroviruses were identified in 68%, 80% and 81% of the stool samples at 6, 12 and 18 months children, rhinovirus in 28%, 18% and 31%, norovirus in 24%, 22% and 16%, parechovirus in 23%, 17% and 17%, rotavirus in 3%, 1% and 0.6%,Giardia lambliain 9.6%, 23.5% and 26%, andCryptosporidium(spp.) in 6%, 8% and 2% of the 6, 12 and 18 months stool samples. Dry season (May–October) was associated with a low infection rate of enterovirus, norovirus andCryptosporidium(spp.). Higher father's education level, less number of person in the household and higher sanitation were associated with a low infection rate of enterovirus, norovirus and rotavirus, respectively. The results suggest that the prevalence of asymptomatic viral and parasitic infections is high among Malawian children and that the family's living conditions and seasonality influence the rate of infections.
Nipah virus infection: A review
Authors: Aditi  , Shariff M. 
Published: February 2019

AbstractNipah virus (NiV) is an emerging bat-borne pathogen. It was first identified 20 years ago in Malaysia and has since caused outbreaks in other parts of South and Southeast Asia. It causes severe neurological and respiratory disease which is highly lethal. It is highly infectious and spreads in the community through infected animals or other infected people. Different strains of the virus show differing clinical and epidemiological features. Rapid diagnosis and implementation of infection control measures are essential to contain outbreaks. A number of serological and molecular diagnostic techniques have been developed for diagnosis and surveillance. Difficulties in diagnosis and management arise when a new area is affected. The high mortality associated with infection and the possibility of spread to new areas has underscored the need for effective management and control. However, no effective treatment or prophylaxis is readily available, though several approaches show promise. Given the common chains of transmission from bats to humans, a One Health approach is necessary for the prevention and control of NiV infection.
Characterizing the Transition From Balanced to Unbalanced Motions in the Southern California Current
Authors: Chereskin Teresa K. , Rocha Cesar B. , Gille Sarah T. , Menemenlis Dimitris , Passaro Marcello 
Published: February 2019

AbstractAs observations and models improve their resolution of oceanic motions at ever finer horizontal scales, interest has grown in characterizing the transition from the geostrophically balanced flows that dominate at large‐scale to submesoscale turbulence and waves that dominate at small scales. In this study we examine the mesoscale‐to‐submesoscale (100 to 10 km) transition in an eastern boundary current, the southern California Current System (CCS), using repeated acoustic Doppler current profiler transects, sea surface height from high‐resolution nadir altimetry and output from a (1/48)° global model simulation. In the CCS, the submesoscale is as energetic as in western boundary current regions, but the mesoscale is much weaker, and as a result the transition lacks the change in kinetic energy (KE) spectral slope observed for western boundary currents. Helmholtz and vortex‐wave decompositions of the KE spectra are used to identify balanced and unbalanced contributions. At horizontal scales greater than 70 km, we find that observed KE is dominated by balanced geostrophic motions. At scales from 40 to 10 km, unbalanced contributions such as inertia‐gravity waves contribute as much as balanced motions. The model KE transition occurs at longer scales, around 125 km. The altimeter spectra are consistent with acoustic Doppler current profiler/model spectra at scales longer than 70/125 km, respectively. Observed seasonality is weak. Taken together, our results suggest that geostrophic velocities can be diagnosed from sea surface height on scales larger than about 70 km in the southern CCS.
Representation of Model Error in Convective‐Scale Data Assimilation: Additive Noise Based on Model Truncation Error
Authors: Zeng Yuefei , Janjić Tijana , Sommer Matthias , de Lozar Alberto , Blahak Ulrich , Seifert Axel 
Published: February 2019

AbstractTo account for model error on multiple scales in convective‐scale data assimilation, we incorporate the small‐scale additive noise based on random samples of model truncation error and combine it with the large‐scale additive noise based on random samples from global climatological atmospheric background error covariance. A series of experiments have been executed in the framework of the operational Kilometre‐scale ENsemble Data Assimilation system of the Deutscher Wetterdienst for a 2‐week period with different types of synoptic forcing of convection (i.e., strong or weak forcing). It is shown that the combination of large‐ and small‐scale additive noise is better than the application of large‐scale noise only. The specific increase in the background ensemble spread during data assimilation enhances the quality of short‐term 6‐hr precipitation forecasts. The improvement is especially significant during the weak forcing period, since the small‐scale additive noise increases the small‐scale variability which may favor occurrence of convection. It is also shown that additional perturbation of vertical velocity can further advance the performance of combination.
Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion
Authors: Li Bin , Song Tie-Niu , Wang Fu-Rong , Yin Ci , Li Zheng , Lin Jun-Ping , Meng Yu-Qi , Feng Hai-Ming , Jing Tao 
Published: February 2019

AbstractMacrophages constitute one of the most common components of immune cells, which penetrate tumors and they have a key role in tumor prognosis. Here, we identified an unrecognized macrophage subpopulation, which favors tumorigenesis. These macrophages express programmed cell death protein 1 (PD1) in a constitutive manner and accumulates in esophageal squamous cell carcinoma (ESCC) in advanced stage of the disease and is negatively associated with the survival of ESCC patients. The PD1+ tumor-associated macrophages (PD1+ TAMs) displayed surface pattern and function akin to M2: a substantial enhancement in CD206 and IL-10 expression; a specific reduction in HLA-DR, CD64, and IL-12 expression; and a significant increase in the ability to inhibit CD8+ T-cell proliferation. Triggering of PD1 signal is effective in increasing PD1+ TAM function. Moreover, exosomal HMGB1 obtained from tumors are efficient in triggering differentiation of monocytes into PD1+ TAMs, which display phenotypic and functional properties of M2. Overall, our work is the first finding to confirm that exosomal HMGB1 obtained from ESCC can successfully trigger clonal expansion of PD1+ TAM. Further, as the macrophages exhibit an M2-like surface profile and function, thereby creating conditions for development of ESCC. Thus, effective methods of treatment include combining immunotherapy with targeting PD1+ TAMs and tumor-derived exosomal HMGB1 to resuscitate immune function in individuals suffering from ESCC.
Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy
Authors: Li Chang , Huang Lihong , Sun Wei , Chen Ying , He Ming-Liang , Yue Jianbo , Ballard Heather 
Published: February 2019

AbstractThe dysregulation of autophagy, an evolutionarily conserved lysosomal degradation process, has been implicated in a wide variety of human diseases, and thus, small chemicals that modulate autophagy have therapeutic potential. Here, we assessed the ability of active components isolated from Bupleurum falcatum, a popular Chinese herb, to modulate autophagy. We found that saikosaponin D (SsD) and A (SsA) but not C (SsC) potently and reversibly inhibited the fusion of autophagosomes and lysosomes, resulting in the accumulation of autophagosomes, an increased lysosomal pH, and TFEB nuclear translocation. RAB5A knockdown or the expression of a dominant-negative RAB5 mutant significantly reduced the ability of SsD or SsA to block autophagy. Enterovirus A71 (EV-A71), the cause of hand-foot-mouth disease, has been shown to induce autophagy. We found that SsD potently inhibited EV-A71 RNA replication and subsequent viral protein synthesis, thereby preventing EV-A71-induced cell death. ATG5 knockdown inhibited EV-A71 viral protein synthesis, whereas autophagy induction by rapamycin promoted synthesis. Taken together, our data indicate that SsD and SsA are potent late-stage autophagy inhibitors that can be used to prevent EV-A71 infection.
Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
Authors: Seo Min Ji , Lee Dong Min , Kim In Young , Lee Dongjoo , Choi Min-Koo , Lee Joo-Youn , Park Seok Soon , Jeong Seong-Yun , Choi Eun Kyung , Choi Kyeong Sook 
Published: February 2019

AbstractGambogic acid (GA), a xanthonoid extracted from the resin of the tree,Garcinia hanburyi, was recently shown to exert anticancer activity in multiple studies, but the underlying action mechanism remains unclear. Here, we show that GA induces cancer cell death accompanied by vacuolation in vitro and in vivo. This GA-induced vacuolation in various cancer cells was derived from dilation of the endoplasmic reticulum (ER) and mitochondria, and was blocked by cycloheximide. These findings suggest that GA kills cancer cells by inducing paraptosis, a vacuolization-associated cell death. We found that megamitochondria formation, which arose from the fusion of swollen mitochondria, preceded the fusion of ER-derived vacuoles. GA-induced proteasomal inhibition was found to contribute to the ER dilation and ER stress seen in treated cancer cells, and megamitochondria formation was followed by mitochondrial membrane depolarization. Interestingly, GA-induced paraptosis was effectively blocked by various thiol-containing antioxidants, and this effect was independent of ROS generation. We observed that GA can react with cysteinyl thiol to form Michael adducts, suggesting that the ability of GA to covalently modify the nucleophilic cysteinyl groups of proteins may cause protein misfolding and subsequent accumulation of misfolded proteins within the ER and mitochondria. Collectively, our findings show that disruption of thiol proteostasis and subsequent paraptosis may critically contribute to the anti-cancer effects of GA.
MiR-15b and miR-322 inhibit SETD3 expression to repress muscle cell differentiation
Authors: Zhao Meng-Jie , Xie Jun , Shu Wen-Jie , Wang Hong-Yan , Bi Jianping , Jiang Wei , Du Hai-Ning 
Published: February 2019

AbstractSETD3 is a member of SET-domain containing methyltransferase family, which plays critical roles in various biological events. It has been shown that SETD3 could regulate the transcription of myogenic regulatory genes in C2C12 differentiation and promote myoblast determination. However, how SETD3 is regulated during myoblast differentiation is still unknown. Here, we report that two important microRNAs (miRNAs) could repress SETD3 and negatively contribute to myoblast differentiation. Using microRNA (miRNA) prediction engines, we identify and characterize miR-15b and miR-322 as the primary miRNAs that repress the expression of SETD3 through directly targeting the 3’-untranslated region of SETD3 gene. Functionally, overexpression of miR-15b or miR-322 leads to the repression of endogenous SETD3 expression and the inhibition of myoblast differentiation, whereas inhibition of miR-15b or miR-322 derepresses endogenous SETD3 expression and facilitates myoblast differentiation. In addition, knockdown SETD3 in miR-15b or miR-322 repressed myoblasts is able to rescue the facilitated differentiation phenotype. More interestingly, we revealed that transcription factor E2F1 or FAM3B positively or negatively regulates miR-15b or miR-322 expression, respectively, during muscle cell differentiation, which in turn affects SETD3 expression. Therefore, our results establish two parallel cascade regulatory pathways, in which transcription factors regulate microRNAs fates, thereby controlling SETD3 expression and eventually determining skeletal muscle differentiation.
Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression
Authors: Cai Xiaoyan , Zhao Zheng , Dong Jiangnan , Lv Qiang , Yun Bei , Liu Jiangqi , Shen Yan , Kang Jie , Li Jun 
Published: February 2019

AbstractCircular RNAs (circRNAs) are a class of non-coding RNAs that are broadly expressed in various biological cells and function in regulating gene expression. They are structurally stable and tissue-specific. However, the function of human circRNAs and the role of circRNAs in papillary thyroid carcinoma (PTC) remain to be determined. Herein, the function of circRNA circBACH2 was investigated in human PTC cells. First, we detected the expression of circBACH2 in PTC tissues and PTC cell lines by RT-PCR. FISH was used to confirm the subcellular localization of circBACH2. A luciferase reporter assay and AGO2-RIP was used to confirm the relationship between circBACH2 and miR-139-5p. PTC cells were stably transfected with siRNA against circBACH2 and cell proliferation, migration and invasion were detected to evaluate the effect of circBACH2 in PTC, while tumorigenesis was assayed in nude mice. We found that circBACH2 was highly expressed in PTC tissues and PTC cell lines. Mechanistically, we confirmed that circBACH2 could directly bind to miR-139-5p and relieve suppression of the target LMO4. Functionally, we found that inhibiting circBACH2 expression decreased cell proliferation, migration, and invasion. Finally, down-regulating circBACH2 suppressed the growth of PTC xenografts in nude mice. Our findings indicate that circBACH2 acts as a novel oncogenic RNA that sponges miR-139-5p and can be used as a tumor biomarker of PTC. What’s more, these results revealed that the circBACH2/miR-139-5p/LMO4 axis could be targeted as a potential treatment strategy for PTC.