bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglia-Mediated Synapse Loss in Alzheimer's Disease
Authors: Rajendran Lawrence , Paolicelli Rosa C. 
Published: March 2018

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's disease (AD). Thus far, microglia have rather been known as modulator of neurodegeneration with functions limited to neuroinflammation and release of neurotoxic molecules. However, several recent studies have demonstrated a direct role of microglia in “neuro” degeneration observed in AD by promoting phagocytosis of neuronal, in particular, synaptic structures. While some of the studies address the involvement of the β-amyloid peptides in the process, studies also indicate that this could occur independent of amyloid, further elevating the importance of microglia in AD. Here we review these recent studies and also speculate about the possible cellular mechanisms, and how they could be regulated by risk genes and sleep. Finally, we deliberate on possible avenues for targeting microglia-mediated synapse loss for therapy and prevention.Dual Perspectives Companion Paper:Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models by William M. Vanderheyden, Miranda M. Lim, Erik S. Musiek, and Jason R. Gerstner
Site-Specific Fat-1 Knock-In Enables Significant Decrease of n-6PUFAs/n-3PUFAs Ratio in Pigs
Authors: Li Mengjing , Ouyang Hongsheng , Yuan Hongming , Li Jianing , Xie Zicong , Wang Kankan , Yu Tingting , Liu Minghao , Chen Xue , Tang Xiaochun , Jiao Huping , Pang Daxin 
Published: March 2018

Abstract
The fat-1 gene from Caenorhabditis elegans encodes a fatty acid desaturase which was widely studied due to its beneficial function of converting n-6 polyunsaturated fatty acids (n-6PUFAs) to n-3 polyunsaturated fatty acids (n-3PUFAs). To date, many fat-1 transgenic animals have been generated to study disease pathogenesis or improve meat quality. However, all of them were generated using a random integration method with variable transgene expression levels and the introduction of selectable marker genes often raise biosafety concern. To this end, we aimed to generate marker-free fat-1 transgenic pigs in a site-specific manner. The Rosa26 locus, first found in mouse embryonic stem cells, has become one of the most common sites for inserting transgenes due to its safe and ubiquitous expression. In our study, the fat-1 gene was inserted into porcine Rosa 26 (pRosa26) locus via Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated 9 (Cas9) system. The Southern blot analysis of our knock-in pigs indicated a single copy of the fat-1 gene at the pRosa26 locus. Furthermore, this single-copy fat-1 gene supported satisfactory expression in a variety of tissues in F1 generation pigs. Importantly, the gas chromatography analysis indicated that these fat-1 knock-in pigs exhibited a significant increase in the level of n-3PUFAs, leading to an obvious decrease in the n-6PUFAs/n-3PUFAs ratio from 9.36 to 2.12 (***P &lt; 0.0001). Altogether, our fat-1 knock-in pigs hold great promise for improving the nutritional value of pork and serving as an animal model to investigate therapeutic effects of n-3PUFAs on various diseases.
Parental Adverse Childhood Experiences and Offspring Development at 2 Years of Age
Authors: Folger Alonzo T. , Eismann Emily A. , Stephenson Nicole B. , Shapiro Robert A. , Macaluso Maurizio , Brownrigg Maggie E. , Gillespie Robert J. 
Published: March 2018

OBJECTIVES:
The study objective was to determine if maternal and paternal exposure to adverse childhood experiences (ACEs) have a significant association with negative offspring development at 24 months of age in a suburban pediatric primary care population.

METHODS:
A retrospective cohort study was conducted of 311 mother-child and 122 father-child dyads who attended a large pediatric primary care practice. Children were born from October 2012 to June 2014, and data were collected at the 2-, 4-, and 24-month well-child visits. Multivariable Poisson regression with robust error variance was used to model the relationship between self-reported parental ACEs and the outcomes of suspected developmental delay at 24 months and eligibility for early intervention services.

RESULTS:
For each additional maternal ACE, there was an 18% increase in the risk for a suspected developmental delay (relative risk: 1.18, 95% confidence interval: 1.08–1.29). A similar trend was observed for paternal ACEs (relative risk: 1.34, 95% confidence interval: 1.07–1.67). Three or more maternal ACEs (versus &lt;3 ACEs) was associated with a significantly increased risk for a suspected developmental delay that affected multiple domains. Similar effects were observed for early intervention services.

CONCLUSIONS:
Parental ACE exposures can negatively impact child development in multiple domains, including problem solving, communication, personal-social, and motor skills. Research is needed to elucidate the psychosocial and biological mechanisms of intergenerational risk. This research has implications for the value of parental ACE screening in the context of pediatric primary care.
LAMOST DR1 ve WASP'ta ki düşük metal bolluklu zonklayan yıldızlar
Authors: Kahraman Aliçavuş Filiz 
Published: March 2018

Bu çalışmada “LAMOST Data Release 1 (DR1)” tayfsal veri
tabanında yer alan düşük metal bolluklu zonklayan yıldızların incelemesi
sunulmuştur. Çalışmada kullanılan sistemler LAMOST DR1 katalogunda yer alan ve
metal bolluğu -2.4 ile -0.5 dex, etkin sıcaklığı 6500 ile 8600 K ve yüzey çekim
ivmesi log g = 3.8 – 4.5 aralığında
bulunan yıldızlardan seçilmiştir. Seçilen yıldızların fotometrik verileri ise
WASP katalogundan alınmıştır. Fotometrik veriler kullanılarak ışık değişimi
gösteren yıldızlar belirlenmiş ve değişim frekansları elde edilmiştir. Sonuç
olarak analiz edilen sistemlerden beşi kesin, ikisi aday RR Lyrae ve üçü de
aday SX Phoenix yıldızı olarak tanımlanmıştır.
Ayrıca, yıldızların tayf türleri, etkin sıcaklık değerleri ve dönme hızlarıda
tayfsal verilerin analizi ile elde edilmiştir.
60-72 Aylık Çocukların Prososyal Davranışları ile Anne-Babalarının Prososyal Davranışları Arasındaki İlişkinin İncelenmesi
Authors: BAĞCI ÇETİN Burcu , ÖZTÜRK SAMUR Ayşe 
Published: March 2018

Bu
araştırmada, okul öncesi eğitim kurumuna devam eden 60-72 aylık çocukların
prososyal davranışları ile anne-babalarının prososyal davranışları arasındaki
ilişkinin incelenmesi, çocukların prososyal davranışlarının çeşitli
değişkenlere göre (cinsiyet, kardeş sayısı, okul öncesi eğitim kurumuna devam
etme süreleri) farklılaşıp farklılaşmadığının belirlenmesi amaçlanmıştır.
Araştırmanın örneklemini tesadüfî örnekleme yöntemi ile belirlenmiş 200 çocuk
ve anne-babaları oluşturmuştur. Veri toplama aracı olarak Bağcı (2015) tarafından Türkçe’ ye
uyarlanarak geçerlik güvenirlik çalışması yapılan “Çocuk Prososyallik Ölçeği”
ve “Yetişkin Prososyallik Ölçeği”
kullanılmıştır.
Veriler
SPSS 20 ve Lisrel paket programı ile analiz edilmiştir.

Araştırma
sonucunda, anne-baba prososyallik puanı ile çocuk prososyallik puanları
arasında pozitif yönlü anlamlı bir ilişki gözlenmiştir. ÇPÖ öğretmen formu puanlarının kızlar lehine, ÇPÖ anne formu puanlarının
kardeş sayısı değişkenine göre anlamlı bir farklılık gösterdiği tespit
edilmiştir.
Evaluation of recurrence and postoperative pain in laparoscopic inguinal hernia repair with mesh fixation verses without mesh fixation
Authors: Prasad Dinesh , Khedkar Indira , Modi Mitesh 
Published: March 2018

Background: Inguinal hernia affects both men and women but is much more common in men who comprise over 90% of operated patients. The purpose of this study was to determine whether elimination of tacking the mesh during endoscopic inguinal hernia repair results in decreased postoperative pain or complications, or both, without increasing the incidence of hernia recurrence.Methods: Patients age between 18 to 70 yrs, willing for laparoscopic surgery, suitable for elective laparoscopic surgery were included in the study. TEP or TAPP endoscopic inguinal hernia repairs would be performed with the patient under general anesthesia. Data collection have done by using a structured pre-prepared case performa. The patient evaluated both by radiological and laboratory investigations both pre-operatively and post-operatively.Results: There is no major significant difference in pain at 1 month after operation in both the group. Recurrence was higher among patient having mesh fixation and it was not statistically significant. Wound infection was occurring more among without fixation group and it was not statistically significant. Urinary retention was reported more among without fixation group and it was not statistically significant. Conclusions: Thus, it was concluded that there is no significant difference in recurrence rate in the both study group either with fixation or without fixation. There is no significant difference in pain at one month in the both study group either with fixation or without fixation. There is more pain (visual analogue scale more than two) at three months after operation in fixation group as compared to without fixation group. There is also high cost in fixation group as compared to without fixation group.
The effect body mass index on varicocele
Authors: Mohammad Ehab Jasim , Abbas Kanaan Mahdi , Abd Ali Hussein , Abdulrazaq Alaa Abdulqader 
Published: March 2018

Background: Varicocele, is the most common abnormal finding among men presenting with infertility, yet controversy exist regarding their etiology. Anecdotal experience suggests that varicoceles are more prevalent in lean men, supporting the “nutcracker” effect of the superior mesenteric artery compressing the left renal vein over the aorta. The aim of this study was to determine the association between Body Mass Index (BMI) and occurrence of varicocele.Methods: A total of 100 males with varicocele attending the urological outpatient clinic were evaluated from their physical screening examinations. All subjects underwent history taking and physical examinations to evaluate for the presence and severity of varicocele, height, weight, and BMI, those compared with 100 men without varicocele (control group) were selected randomly from general population.Results: The mean BMI of the 100 patients with varicocele was 26.1620 while that of the control group was 29.7330 (P= 0.0001) which is clinically significant. Varicocele grade decreased with increasing BMI category (P= 0.0001).Conclusions: The results of this study indicate that there is a decreasing incidence of varicocele and varicocele grade with increasing BMI, Supporting the possibility that obesity results in a decreased nutcracker effect in which the adipose tissue prevents compression of the renal vein.
A Simulation Model for Pricing the Spread in a Credit Default Swap: Application and Analysis<sup>#</sup>
Authors: Sethi Madhvi , Thakkar Parthiv , Jamal Zahid M. 
Published: March 2018

This paper explores pricing the contract of a Credit Default Swap (CDS) using a simulation model. It attempts to determine the spread value which is a periodic payment to be made by the protection buyer. It also helps in identifying the factors that should be taken into account to determine the true value of the payment which would hedge the risk in case of a credit event by the issuer of the underlying asset. The paper uses the Hull and White pricing model for creating the simulation model. This model is then applied to analyse CDSs of countries having different credit ratings. The paper using the model analyses the actual and estimated spread of the different countries and discusses the possible reasons for the same.<ins cite="mailto:Windows%20User" datetime="2018-01-07T00:55"> </ins>
The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases
Authors: Tomczyńska Małgorzata , Saluk-Bijak Joanna 
Published: March 2018

Autoimmune thyroid diseases include several distinct clinical entities and mainly concern Graves` disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body’s own tissues and the production of antibodies against specific cell antigens, accompanied by chronic inflammation occur in autoimmune thyroid diseases. The autoimmune process is induced by difficult to identify genetic and environmental factors, and generates the development of concomitant diseases of other systems. The inflammatory mediators, high level of thyroid hormones, lymphocyte activation and other immune cells play an important role in the chronic course of these diseases. Autoimmune thyroid diseases are caused by disruptions of T-cells and other cells functions. The autoantibodies react with target antigens in different kinds of cells, including blood platelets. The autoimmune processes can cause the increased activity different kinds of cells including blood platelets and lymphocytes. The activity of blood platelets and lymphocytes is reciprocally regulated. It is suggested that blood platelets can influence lymphocyte function by direct contact through the receptors and via soluble mediators. The platelet–immune cell interactions represent a hallmark of immunity, as they can potently enhance immune cell functions.
An Action Research Approach helps Develop GIS Programs in Humanities and Social Sciences
Authors: Costello Laura 
Published: March 2018

A Review of:
Kong, N., Fosmire, M., & Branch, B. D. (2017). Developing library GIS services for humanities and social science: An action research approach. College & Research Libraries, 78(4), 413-427. http://dx.doi.org/10.5860/crl.78.4.413
Abstract
Objective – To develop and improve on geographic information systems (GIS) services for humanities and social sciences using an action research model.
Design – Case study.
Setting – A public research university serving an annual enrollment of over 41,500 students in the Midwestern United States.
Subjects – Faculty members and students in the humanities and social sciences that expressed interest in GIS services.
Methods – An action research approach was used which included data collection, analysis, service design, and observation. Interviews with 8 individuals and groups were conducted including 4 faculty members, 3 graduate students, and one research group of faculty and graduate students. Data from interviews and other data including emails and notes from previous GIS meetings were analyzed and coded into thematic areas. This analysis was used to develop an action plan for the library, then the results of the activity were assessed.
Main Results – The interviews revealed three thematic areas for library GIS service: research, learning, and outreach. The action plan developed by the authors resulted in increased engagement including active participation in an annual GIS day, attendance at workshops, course-integrated GIS sessions, around 40 consultations on GIS subjects over a two-year period, and increased hits on the Library’s GIS page. Surveys from pre- and post-tests in the workshops increased participants’ spatial awareness skills. Conclusion – Using an action research approach, the authors were able to identify needs and develop a successful model of GIS service for the humanities and social sciences.
A Text Recognizing Device For Visually Impaired
Authors: Tejaswani G. , B Afroz. , S Sunitha. 
Published: March 2018

In the present world visually impaired people use Braille lipi language to read the books, but those books are available only in particular places like library etc. It has become very difficult for the visually impaired peoples to come out into the real world. Braille cannot be used in every place like in the mobiles, supermarket, and news papers. Due to this it has become difficult for the visually impaired people to read the text. To overcome this difficulties faced by the visually impaired, finger reader with speech assistance is used to read any printed text from the mobiles, news papers etc. we are using the assistive technology in this device to provide the assistance for the visually impaired people
Military Based Security System Using Raspberry Pi
Authors: Kavitha S. , Varshini S.R.Kamali , Vijayalakshmi Mrs.P. 
Published: March 2018

In today’s world Indian border military force is facing a huge destruction. Hence, most of the military organizations take the help of military robots to carry out risky jobs which cannot be handled by humans. In this proposal, we design and implement in such a way that the robotic vehicle can enter into an area of higher risks, move and place wherever the object wants to go and captures intruder’s image. It has human detection Pi camera and temperature and gas detecting sensor that can provide precaution to potential crimes, fire and leakage of any gases. The credit card sized Raspberry Pi with Open Source Computer Vision (OpenCV) software controls the face detection algorithm and sends captured pictures to the user’s email via WI-FI. The pi-camera serves as the eye of the robot and provides us live video streaming. The biggest advantage of the system is that the user can get the picture of the intruder from anywhere in the world and can respond according to the risks in the situations.

The prime objectives of this paper are:

To find the presence of an intruder - if detects, captures images and sends it to the given email address.
Enables control of the robotic vehicle –i.e. The robot can be moved in any directions from the user present in any location.
To find the presence of any gases present in the surrounding other than the normal air and warns the nearby person with its buzzing.
Can monitor the location at any remote distance via live surveillance.
To find the temperature of the environment
Survey of new attack models on Cloud Infrastructure
Authors: Singh Har Preet 
Published: March 2018

Cloud Computing is currently most useful technol- ogy around the globe which offers an innovative business models for infrastructure to the enterprise , software services to the end users and the easy to deploy platform to the developer on Internet using virtual machine , for the quick and easy accessibility. It is Internet driven technology, which gives pool of resources such as Storage , Network , Application on demand basis. As the technology is driven over the Internet and virtual machine and allow resource pooling their are various kind of security problem arise relate to the model architecture, multi-tenancy, elasticity, data confidentiality, authentication and authorization. Various kind of attack could happen in cloud infrastructure ,as there is no exact definition about the attack and attack model but here we try to group into a various levels eg. Network level, host level and application level and few other attacks and the solution to prevent the attacks. In this paper we will discuss about the different kind of attacks and solution on cloud services
Implementation Of Teacher And Lecturer Policy At Vocation Education System Of The Indonesian Navy
Authors: Sutristyanto Isworo , . Sumartono , S. Haryono Bambang , Mindarti Lely I. 
Published: March 2018

Nowadays, the policy of national higher education has an influence on higher education in the Indonesian Navy in patterns and structures, types of education, educational outcomes or graduates of each educational strata. The human resources of the Navy were built by an using expert system with the field of each assignment being scholar soldier, with the development domain is Cognitive, Affective and Psychomotor Domains Granding. The equalization of graduates between academic and vocational education influences on the quantity and quality of standardized military lecturers as educators in the Navy education system which is harmonized with the prevailing national policy. Based on the existing gap due to the implementation of lecturer policy, the efforts that have been done, the purposes of this study are : 1) Describe and analyze the implementation of teacher and lecturer policy on Higher Education Vocation of the Indonesian Navy service vocation; 2) Finds the implementation model of policy of teacher and lecturer in higher education of vocation of the Indonesian Navy. In this research, the paper used Merilee S. Grindle model approach. It model uses to describe the implementation of policy of teachers and lecturers in higher education vocational service of the Indonesian Navy. The result of the policy implementation on vocation system of teacher and lecturer in higher education system of the Indonesian Navy has not given any significant result change, because there are still many obstacles in the process. The model of policy implementation of teacher and lecturer in higher education vocation of the Indonesian Navy officially started by synchronizing policy between the Higher Education Institution and the Indonesian Navy then it is passed down to specific socialization program to support of lecturer policy objectives.
Effect of Leadership, Personality and Job Satisfaction On Job Performance of Diplomat
Authors: Hadiningrat June Kuncoro , R. Luddin Muchlis , Suyatno Thomas 
Published: March 2018

This research aims to study the effect of leadership, personality and job satisfaction on diplomat performance in the Ministry of Foreign Affairs of the Republic of Indonesia. The research methodology was a survey with path analysis applied in testing hypothesis. It was conducted among 158 diplomats selected by simple random sampling from 657 young diplomat population. Data analysis and interpretation indicate that (1) leadership has a positive direct effect on job performance of diplomat/diplomat performance, (2) personality has a positive direct effect on diplomat performance, (3) job satisfaction has a positive direct effect on diplomat performance, (4) leadership has a positive direct effect on job satisfaction, (5) personality has a positive direct effect on job satisfaction.
Occurrence of post-endodontic pain after single-visit RCT using Balanced Force technique and two reciprocating system when apical patency is maintained
Authors: Paredes Vieyra Dr. Jorge , Ocampo Acosta Fabian , Jiménez Enriquez Francisco Javier , Rojas Alvarado Rosendo Andres 
Published: March 2018

Aim. The goal of this research was to relate the occurrence of post-endodontic pain after single-visit RCT using Balanced Force technique and two reciprocating system when AP is conserved.
Methodology: Two hundred and sixteen of 245 patients aged 18-65 years were incorporated in this research. All patients had teeth selected for conventional RCT for prosthetic reasons detected with only vital pulps. For hand instrumentation, Balanced Force were used. All canals were clean and shaped with hand Flex-R files. For mechanical shaping, all instruments were prepared with Protaper Next and Reciproc instruments in continuous brushing and reciprocating mode respectively. Final irrigation with cold (8oC) 17% EDTA served as a lubricant.
Results: The average age of the 216 participants registered in this research was 54 years. No statistically significant difference (p > .05) among the groups were found regarding degree or duration of pain. There was no statistically significant difference (p> .05) among the Balanced Force technique, PTN and R techniques in relation to the occurrence of post/endodontic ache at any of the three time points measured (Table 3, 4).
Conclusions. The incidence of post-endodontic pain is lower when AP is maintained and presence/absence of pre-operative pain has to be consider. When previous symptoms are present, occurrence and period of pain is longer in teeth with this condition that when AP is maintained. It can be established that conserving AP with a thin K-file can help to prevent post-endodontic pain in some specific cases.