bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adeno‐associated virus‐mediated over‐expression of CREB‐regulated transcription coactivator 1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide‐induced depression‐like behaviour in mice
Authors: Ni Saiqi , Huang Hua , He Danni , Chen Hang , Wang Chuang , Zhao Xin , Chen Xiaowei , Cui Wei , Zhou Wenhua , Zhang Junfang 
Published: January 2019

AbstractDepression is a highly complex global disabling psychiatric disorder. Unfortunately, the currently available antidepressants are not effective in a significant percentage of patients. Therefore, the underlying mechanisms of depression must be explored at the molecular level to discover new candidate molecular targets for depression treatment. Behavioural and molecular depression‐like endophenotypes have been observed in cyclic AMP response element‐binding protein‐regulated transcription coactivator 1 (Crtc1) knockout mice; however, the underlying mechanism for these endophenotypes remains unclear. This work investigated the role of hippocampal CREB‐regulated transcription coactivator 1 (CRTC1) in depression using a recombinant adeno‐associated virus (AAV) system to alter Crtc1 gene expression and explore its potential mechanism. We found that shRNA‐mediated Crtc1 gene knockdown (AAV‐shCRTC1) in the dentate gyrus regions of the ventral hippocampus directly resulted in depression‐like behaviours and down‐regulation of brain‐derived neurotrophic factor and neuropeptide VGF levels. A widely used depression model induced by lipopolysaccharide administration (0.5 mg/kg, i.p.) was applied in our study and was validated by increased immobility time in the tail‐suspension and forced swim tests and decreased sucrose consumption in the sucrose preference test. Importantly, CRTC1 over‐expression mediated by AAV‐CRTC1 in the ventral dentate gyrus regions prevented lipopolysaccharide‐induced depressive‐like behaviours, the down‐regulation of brain‐derived neurotrophic factor and VGF, and the accumulation of pro‐inflammatory cytokines such as interleukin‐6, interleukin 1‐β and tumour necrosis factor α in mice. Together, our findings indicate that CRTC1 is a key factor in depression‐like behaviour and provide an important reference for finding a novel drug target in the neuroinflammatory and neurotrophic pathways for curing depressive disorders.
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Cover Image for this issue: doi: 10.1111/jnc.14500.
Venlafaxine stimulates PNN proteolysis and MMP‐9‐dependent enhancement of gamma power; relevance to antidepressant efficacy
Authors: Alaiyed Seham , Bozzelli P. Lorenzo , Caccavano Adam , Wu Jian Young , Conant Katherine 
Published: January 2019

AbstractDrugs that target monoaminergic transmission represent a first‐line treatment for major depression. Though a full understanding of the mechanisms that underlie antidepressant efficacy is lacking, evidence supports a role for enhanced excitatory transmission. This can occur through two non‐mutually exclusive mechanisms. The first involves increased function of excitatory neurons through relatively direct mechanisms such as enhanced dendritic arborization. Another mechanism involves reduced inhibitory function, which occurs with the rapid antidepressant ketamine. Consistent with this, GABAergic interneuron‐mediated cortical inhibition is linked to reduced gamma oscillatory power, a rhythm also diminished in depression. Remission of depressive symptoms correlates with restoration of gamma power. As a result of strong excitatory input, reliable GABA release, and fast firing, PV‐expressing neurons (PV neurons) represent critical pacemakers for synchronous oscillations. PV neurons also represent the predominant GABAergic population enveloped by perineuronal nets (PNNs), lattice‐like structures that localize glutamatergic input. Disruption of PNNs reduces PV excitability and enhances gamma activity. Studies suggest that monoamine reuptake inhibitors reduce integrity of the PNN. Mechanisms by which these inhibitors reduce PNN integrity, however, remain largely unexplored. A better understanding of these issues might encourage development of therapeutics that best up‐regulate PNN‐modulating proteases. We observe that the serotonin/norepinephrine reuptake inhibitor venlafaxine increases hippocampal matrix metalloproteinase (MMP)‐9 levels as determined by ELISA and concomitantly reduces PNN integrity in murine hippocampus as determined by analysis of sections following their staining with a fluorescent PNN‐binding lectin. Moreover, venlafaxine‐treated mice (30 mg/kg/day) show an increase in carbachol‐induced gamma power in ex vivo hippocampal slices as determined by local field potential recording and Matlab analyses. Studies with mice deficient in matrix metalloproteinase 9 (MMP‐9), a protease linked to PNN disruption in other settings, suggest that MMP‐9 contributes to venlafaxine‐enhanced gamma power. In conclusion, our results support the possibility that MMP‐9 activity contributes to antidepressant efficacy through effects on the PNN that may in turn enhance neuronal population dynamics involved in mood and/or memory.
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Cover Image for this issue: doi: 10.1111/jnc.14498.
Co‐existence of Juvenile dermatomyositis and psoriasis vulgaris with fungal infection: A case report and literature review
Authors: Xing Yaqiong , Xie Jun , Jiang Si , Upasana Manandhar , Song Jiquan 
Published: January 2019

SummaryIntroductionThe incidence rate of psoriasis vulgaris (PSV) coexisting with Juvenile dermatomyositis (JDM) is low. Through our thorough literature search, we found that PSV arising on JDM with superficial fungal infection of facial skin is rarely reported. So, we hereby, report a case of combination of the above three diseases. Meanwhile, we also reviewed the previous literatures aiming at the related basis, clinical manifestation, diagnosis, and treatment of the diseases. Interestingly, of all cases, this case is the only one in which the symptom of muscle weakness preceded the appearance of rash.Case PresentationA 21‐year‐old man diagnosed with JDM 6 years ago came to our inpatient department due to the appearance of new rash. Skin examination showed some sharply demarcated scaly plaques over the head, neck, torso, and bilateral upper limbs with pruritus and scaling. Histological examination and typical clinical manifestation confirmed the diagnosis of PSV for his new rash. Family history was negative for JDM and PSV. The clear erythema located on his face revealed the existence of superficial fungal infection with the help of fungal fluorescence microscopy. He had marked improvement of his symptoms with the treatment given at our department. In the past 3 months, the patient has been on regular follow‐up at our outpatient department, and his condition is stable at present.DiscussionThis paper presents a case of PSV arising on JDM coexisting with superficial fungal infection on the face hoping that this will help clinicians in the better diagnosis of the diseases during literature search.
Identification and validation of amino acid‐based mild exfoliating agents through a de novo screening method
Authors: Ahn Byungjun , Lee Seol‐Hoon , Kim Jin‐Hyun , Goh Areum , Park Sun‐Gyoo , Lee Cheon‐Koo , Kang Nae‐Gyu 
Published: January 2019

SummaryBackgroundDue to internal or external factors, the desquamation (turnover) rate of the stratum corneum slows down, resulting in skin problems. Therefore, adjusting the exfoliation rate through cosmetics is an important issue.ObjectiveThis report aimed to develop exfoliating agents with lesser adverse effects and higher efficiency through an ex vivo screening method and in vivo turnover rate analysis of human skin.MethodsVarious molecules were evaluated by the ex vivo porcine skin exfoliation method and screened for their potential as effective agents. To confirm the effect and mechanism of each agent found, the exfoliation efficiency was evaluated. Each agent was also applied to the actual human skin to determine its efficacy and side effects.ResultsDespite the pH 6, carnitine and serine, which have similar or better efficiency compared to PHA, were selected. Based on the results, it was confirmed that calcium. And it is nonirritating to the human skin and increases the turnover rate (~130%).ConclusionAmino acid‐based exfoliating agents, such as carnitine and serine, were identified and verified to enhance the rate of exfoliation of the stratum corneum. It is expected that the improvement of dullness, mild acne, fine wrinkles, and pores through skin exfoliation in the field of cosmetics can be achieved safely through these agents.
Eutrophication modelling of Amirkabir Reservoir (Iran) using an artificial neural network approach
Authors: Homayoun Aria Shiva , Asadollahfardi Gholamreza , Heidarzadeh Nima 
Published: January 2019

AbstractThe complicated non‐linear relationships between water quality and environmental parameters involved in predicting algal blooms necessitate a new approach, using data‐driven modelling. Accordingly, a multilayer perceptron (MLP) and time delay neural network (TDNN) were used to predict the eutrophication status of two monitoring stations in the Amirkabir Reservoir in Iran. Six scenarios for each monitoring station were performed to select a significant, independent input using 12 years of monthly data. The final inputs were temperature, turbidity, phosphate (PO4), nitrate (NO3), nitrite (NO2), ammonium (NH3), dissolved oxygen (DO) and electrical conductivity (EC). Applying an MLP neural network to the upstream monitoring station with 21–38 neurons in the first and second hidden layers, the minimum mean squared errors (MSE) in training, validating and testing were 0.083, 0.81 and 1.95 cells/100 ml, respectively. Further, when the TDNN network was used with the same neuron numbers in the hidden layer for the similar monitoring station, the minimum MSE values for model training, validating and testing were 0.06, 0.72 and 1.76 cells/100 ml, respectively. For the Beylaghan monitoring station, using the MLP neural network with 29–23 neurons in the first and second hidden layer, the minimum MSE values gained in training, validating and testing were 0.181, 0.58 and 0.95 cells/100 ml, respectively. Using the TDNN network with the same neurons in the hidden layers of the MLP neural network for the station, the minimum MSE values for training, validating and testing were 0.152, 0.43 and 0.84 cells/100mL, respectively. Thus, TDNN exhibited a high accuracy and workability, compared to the MLP. Sensitivity analysis of the Amirkabir Reservoir dataset indicated increasing the value of nitrate is the first factor, followed by turbidity and NH3, having the greatest impacts on eutrophication prediction.
Hard‐Core Toughie: Donald Trump’s Negotiations for the United States Presidency
Authors: Kapoutsis Ilias , Volkema Roger 
Published: January 2019

AbstractThis paper examines the negotiation tactics employed by Donald Trump in his 2016 presidential campaign. Drawing on data from multiple sources (interviews, debates, articles, books), our analysis begins with a brief overview of Trump’s personality and philosophy, which offers a basis for understanding his general negotiating approach. We then highlight six competitive tactics and four principles of persuasion that Trump employs, with specific examples of how he used them during the campaign with his primary negotiating counterparts – the other candidates, the Republican Party, the press corps, and the American electorate. Finally, we discuss some of the implications of his negotiating approach and preferred tactics in dealing with domestic and international issues as president of the United States.
Chanteurs de rue, or street singers in early modern France
Authors: McIlvenna Una 
Published: January 2019

AbstractThe impression one tends to have about the profession of the street singer in early modern France is of one voice struggling to be heard amongst a cacophony of other ambulant sellers crying their goods for sale. This vision is encouraged by the centuries‐old genre of the ‘cris de Paris’, immortalised in verse as early as the thirteenth century. This paper outlines in greater detail the figure of the chanteur de rue in the early modern period, from eye‐witness accounts (more plentiful for the eighteenth century), from pictorial evidence, and from clues within the songs themselves. There is evidence to suggest that different types of songs were performed by different types of singers, with the singer of complaintes (execution songs) adopting a costume and demeanour that distinguished him from the singer of ‘profane songs’. However, French songs in the sixteenth century were often sold in cheaply printed recueils, songbooks on a surprisingly diverse range of topics. This paper therefore examines how a street singer might have performed and sold these often heterogenous texts, and how the authorities tried in vain to control and censor these potentially subversive singers of news.
Frail echoes of singing in the streets. Tracing ballad sellers and their reputation in the Low Countries
Authors: Salman Jeroen 
Published: January 2019

AbstractThis article discusses opposing representations of the Dutch ballad singer as political rebel versus entertainer and performer. It reveals how these representations were shaped, how they interacted in cultural practices and how they changed in the Low Countries in the course of the sixteenth and seventeenth century. The underlying question is the relevancy of these street singers in the process of public opinion formation. The period under scrutiny is highly relevant in the context of Dutch history, because it covers the rise of the reformist movement, the revolt of the Northern provinces against the Spanish King, the establishment of the Dutch Republic and growing importance of the local cultural infrastructure. One of the main conclusions is that from the mid‐fifteenth century onwards and including the seventeenth century, ballads and street singing, entertaining as well as propagandistic, were generally seen as a form propaganda and subversion. Despite the often tolerated and even appreciated entertaining function of ballads, the ballad singer from the Dutch revolt onwards remained a distrusted figure.
From beggar to virtuoso: The street singer in the Netherlandish visual tradition, 1500–1600
Authors: Chriscinda Henry 
Published: January 2019

AbstractThis essay surveys the iconography of street singers and musicians in sixteenth‐century Netherlandish painting. It examines the visual and social status of itinerant performers as they move between different roles in the urban marketplace: from sympathetic beggar deserving of charity to diabolical trickster and charlatan, to successful entrepreneur operating within a new market system. The representation of this marginal type extends from grotesque and comic portrayals in late medieval manuscript illuminations and the hallucinatory Hellscapes of Hieronymous Bosch and his followers, to sympathetic depictions as objects of charity in altarpieces of The Seven Works of Mercy, to more ambivalent figurations of pedlars hawking printed wares in serial paintings of biblical narratives in the marketplace by Antwerp‐based artists Pieter Aertsen and Joachim Beuckelaer. The portrait of the street singer that emerges in the highly urbanized Low Countries reflects the burgermoraal (bourgeois morality) of patrons and artists and their attitudes on the social role of the marketplace, the status of consumer capitalism versus civic charity, and most importantly the acceptance of marginal and itinerant individuals who operate outside the norms and regulations of cities and societies.
The ‘Fascinating’ World of the Evil EyeBeware the Evil Eye: The Evil Eye in the Bible and the Ancient World. Volume 1: Introduction, Mesopotamia, and Egypt, John H.Elliott, James Clarke & Co., 2016 (ISBN 978‐0‐227‐17568‐2), xxii + 209 pp., pb £16Beware the Evil Eye: The Evil Eye in the Bible and the Ancient World. Volume 2: Greece and Rome, John H.Elliott, James Clarke & Co., 2016 (ISBN 978‐0‐227‐17613‐9), xxxvi + 334 pp., pb £27.50Beware the Evil Eye: The Evil Eye in the Bible and the Ancient World. Volume 3: The Bible and Related Sources, John H.Elliott, James Clarke & Co., 2017 (ISBN 978‐0‐227‐17667‐2), xxx + 354 pp., pb £32Beware the Evil Eye: The Evil Eye in the Bible and the Ancient World. Volume 4: Postbiblical Israel and Early Christianity through Late Antiquity, John H.Elliott, Wipf and Stock, 2017 (ISBN 978‐1‐4982‐3072‐8), xxvi + 220 pp., pb $29
Authors: Askin Lindsey A. 
Published: January 2019

AbstractThe Evil Eye is a pervasive folkloric belief in the eye as an active organ. Historically, the belief and its related protective practices have been much maligned by modern Western attitudes. Origins of the belief, as best as can be traced, are pinned to ancient Mesopotamia and Egypt. From there, the belief radiated outwards until it was pervasive throughout the ancient Near East and Mediterranean world including, as Elliott argues, ancient Judaism and early Christianity. Conceptualizations of the Evil Eye and related beliefs and protective practices have been found as far as Brazil, Tibet, and Australia and are still expressed in Western society. Elliott's four‐volume work on the Evil Eye in antiquity is a contextual reception history that draws together both textual sources and material culture of this fascinating belief across the ancient world.
Asymmetric effects of financial development on export price and quality across countries
Authors: Choi ByeongHwa , Lugovskyy Volodymyr 
Published: January 2019

AbstractWe derive two novel predictions: financial development has a more pronounced effect on quality in countries with greater labor productivity, and its effect on export prices is U‐shaped in labor productivity. We confirm our predictions empirically and show that the negative effect of financial development on export prices is greatest in middle‐productivity countries, while its positive effect on quality is strongest in the most productive countries. Our findings contribute to the literature on the poverty trap: we argue that improving the quality of financial institutions alone is unlikely to boost quality or lower prices of the poorest countries.
An integral formulation for the global error of Lie Trotter splitting scheme
Authors: Seydaoğlu Muaz 
Published: January 2019

An ordinary differential equation (ODE) can be split into simpler sub equations and each of the sub equations is solved subsequently by a numerical method. Such a procedure involves splitting error and numerical error caused by the time stepping methods applied to sub equations. The aim of the paper is to present an integral formula for the global error expansion of a splitting procedure combined with any numerical ODE solver.
Longitudinal Experience with Remote Monitoring for Automated Peritoneal Dialysis Patients
Authors: Milan Manani Sabrina , Rosner Mitchell H. , Virzì Grazia Maria , Giuliani Anna , Berti Sonia , Crepaldi Carlo , Ronco Claudio 
Published: January 2019

<b><i>Background:</i></b> Peritoneal dialysis (PD) is an ideal model for testing remote monitoring (RM). In this study, we evaluated the RM application longitudinally in stable patients undergoing automated PD (APD). <b><i>Methods:</i></b> This was an observational study, comparing outcomes in patients with (current patients) and without (historical data) exposure of RM. We analyzed cost-effectiveness of RM-APD measuring the number of night alarms, number of hospital visits, direct and indirect costs. <b><i>Results:</i></b> Changes in APD prescription were almost double in the case group (RM) compared to the control group (<i>p</i> = 0.0005). The need for in-person visits and nocturnal alarms was significantly less in RM-APD than in traditional APD (<i>p</i> = 0.01 and <i>p</i> = 0.002, respectively). The distance traveled by patients in the case of RM-APD was reduced by 1,134 km with a time saving of 1,554 min for patients. The overall cost reduction for the PD center in terms of time/nurse and time/physician was 2,647 and 3,673 min, respectively. All these advantages were obtained in the presence of an improved technique survival with a significant reduction of dropouts. All patients found that it is easy to use the RM system and were satisfied with the high level of interaction with the care team and with the possibility of timely resolving technical problems. <b><i>Conclusion:</i></b> These data confirm the long-term benefits of RM applied to APD. RM-APD is cost-effective; it allows early detection and resolution of problems, improved treatment compliance, reduction of patient’s access to hospital center for technical and clinical complications with consequent savings, and improved patient’s quality of life.
Abstract TP17: Outcomes of Large Vessel Occlusion Patients in a Multi-Hospital System With Nihss<6 Treated With Endovascular Thrombectomy vs Medical Management
Authors: Augustine Steven B , Tarpley Jason , Lucas Lindsay , Baraban Elizabeth 
Published: January 2019

With the publication of the 2018 updated acute stroke management guidelines, the American Stroke Association very publically proclaimed the safety and efficacy of endovascular thrombectomy (EVT) for the treatment of acute ischemic stroke due to proximal large vessel occlusion in individuals with NIHSS >=6. The appropriate management of individuals who present with less severe large vessel occlusion (NIHSS < 6) is less certain. Anecdotally, many individuals with low presenting NIHSS who are treated with EVT do well; conversely, about 20% of medically managed stroke patients deteriorate.
We retrospectively analyzed stroke data obtained from a multi-hospital system for large vessel occlusion patients with admission NIHSS < 6 discharged between January 2014 and May 2018, excluding those <18 years of age and those with time of onset or last known well that is unknown or >24hours. Outcomes included length of stay and percentage of patients who died in-hospital or were discharged to hospice, had a discharge other than to home or rehab, and had a discharge mRS ≥2.
A total of 144 patients were included with 45% (n=65) treated by EVT. Those who were treated were younger, had higher admit NIHSS, and were more likely to be transfers. There were no significant differences in in-hospital mortality or discharge to hospice, discharge other than to home or rehab, or discharge mRS ≥2. EVT-treated patients had longer lengths of stay after adjusting for age, admission NIHSS, and LKW-to-door time (+36% (CI: 8, 64); p=0.012). Of EVT-treated patients, 3.1% (n=2) had a sICH and 90.3% (n=56 out of 62) had a successful reperfusion.
When using medical judgment to evaluate the benefit of treating low NIHSS stroke, Interventionists are likely to select individuals who are more symptomatic or have been referred by an outside facility, a trend that achieved significance within our sample. Although the length of stay for individuals treated with EVT was on average one day longer than those who were medically managed, there was no significant difference in complications or outcomes between the two groups. Our findings are consistent with similar analyses and help argue for the safety of EVT for select individuals with presenting NIHSS < 6.