bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycemic index and glycemic load of brief sugary sweets: randomized controlled trials of eight Thai desserts
Authors: Namjud Nuttaphat , Senaprom Sayamon , Ondee Thunnicha , Bumrungpert Akkarach , Heath Julia , Pongpirul Krit 
Published: October 2024

BackgroundThai desserts, celebrated for their exquisite sweetness, are widely enjoyed for personal indulgence and as cherished souvenirs. However, their high sugar content raises concerns regarding health impacts. This study aimed to quantify the glycemic index (GI) and glycemic load (GL) in healthy volunteers following consumption of various Thai desserts, out of 10 renowned desserts from across Thailand, identified by the Tourism Authority of Thailand, characterized by differing sugar levels.MethodEight were selected based on the absence of preservatives and microbial or chemical contaminations. Each participant consumed a 50-g serving of available carbohydrate (50avCHO) from these desserts. Ninety-six healthy volunteers, with a mean age of 31.8 ± 5.7 years, a mean body weight of 57.2 ± 7.3 kg, and 63.5% women, were randomized into eight groups, with each group comprising 12 participants. Blood samples were collected pre-and post-consumption to assess GI and GL values following established protocols.ResultsThe findings revealed that Phetchaburi’s Custard Cake exhibited the lowest GI and GL values (53.4 and 26.7, respectively), with progressively higher values observed in Saraburi’s Curry Puff (61.8 and 30.9), Nakhon Sawan’s Mochi (68.9 and 34.4), Suphan Buri’s Sponge Cake (75.9 and 38.0), Ayutthaya’s Cotton Candy (81.4 and 40.7), Prachuap Khiri Khan’s Pineapple Cheese Cake Biscuit (87.4 and 43.7), Chon Buri’s Bamboo Sticky Rice (109.3 and 54.7), and Lampang’s Crispy Rice Cracker (149.3 and 74.7), respectively.ConclusionThe study demonstrates that while Thai desserts exhibit a range of GI values, their GL values are uniformly high. It underscores the importance of disseminating GI and GL information to consumers, enabling them to make informed dietary choices and moderate their intake of these sugary delicacies.
Patient-reported gastrointestinal symptoms in gastric cancer after laparoscopic distal gastrectomy
Authors: Xiao Shuomeng , Ding Zhi , Zhao Fazhi , Yang Chao , Zhao Ping , Chen Xiaodong , Zhou Xiang , Zhou Huali , Xu Rui 
Published: October 2024

PurposeThis study aimed to compare postoperative gastrointestinal symptoms between patients who underwent laparoscopic distal gastrectomy with Roux-en-Y (R-Y) and Billroth-II with Braun (B-II B) reconstruction.MethodsThis observational study retrospectively analyzed 151 patients (110 in R-Y group and 41 in B-II B group) who underwent laparoscopic distal gastrectomy from January 2020 to December 2021. A comparison was made regarding surgical outcomes, perioperative nutritional and inflammatory markers, postoperative dietary patterns, and gastrointestinal symptoms between the two groups.ResultsThe operation time was longer in the R-Y group than the B-II B group (261.00 ± 56.17 min versus 239.88 ± 57.78 min, p = 0.046). However, there were no significant differences in the length of hospital stay, ASA classification, complications, nutritional and inflammatory indexes, or recovery of postoperative diet between the two groups. Additionally, there were no significant differences in the occurrence of postoperative gastrointestinal symptoms in the post-discharge week (PDW) 1 and postoperative month (POM) 1 between the B-II B and R-Y groups.ConclusionsAbdominal distention emerged as the main gastrointestinal symptom burden in patients with gastric cancer undergoing laparoscopic distal gastrectomy. Both Billroth-II with Braun and R-Y reconstructions exhibited a high and similar incidence of gastrointestinal symptoms in the short term. Therefore, medical staff should pay attention to the management of gastrointestinal symptoms in these patients postoperatively.
Efficacy and safety of ephedra-containing oral medications: a systematic review, meta-analysis, and exploratory dose–response analysis for weight reduction
Authors: Cho Hyeongyu , Oh Jeewoo , Chu Hongmin , Jin Hanbit , Leem Jungtae 
Published: October 2024

IntroductionDespite the widespread use of ephedra in various forms, including food supplements and herbal prescriptions, comprehensive studies reviewing its efficacy and safety across different countries are lacking.MethodsWe systematically searched 5 electronic databases and conducted a meta-analysis of 16 randomized controlled trials (RCTs) on ephedra-containing oral medications (EOMs), performing a dose–response analysis for weight loss.ResultsThe meta-analysis results revealed a statistically significant reduction in the body mass index (BMI) (MD: 1.5 kg/m2; 95% CI: −2.46 to −0.54) and secondary outcomes like body weight (BW) and waist circumference (WC). The dose–response analysis indicated a correlation between ephedra and weight reduction. The safety analysis showed no significant difference in adverse effects between the treatment and control groups (RR = 0.99, 95% CI = 0.80 ∼ 1.21, and p = 0.90).DiscussionIn conclusion, EOMs demonstrated effectiveness in promoting weight loss, and the dose–response analysis indicated a correlation between ephedra and weight reduction. However, additional research is necessary due to the limited number of studies and inconsistent results among the assessment criteria. Moreover, if prescribed by traditional medicine physicians within the permissible daily ephedrine dosage range of 150 mg set by the Food and Drug Administration (FDA) and monitored by healthcare professionals, the risk of severe adverse events is likely to be minimal.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=387895, identifier CRD42023387895.
Bibliometric and visual analysis of SGLT2 inhibitors in cardiovascular diseases
Authors: Pan Runfang , He Yuqing , Melisandre Wan , Zhang Yunyi , Su Wenyuan , Feng Jiaming , Jia Chengyao , Li Shaoling , Liu Baonian 
Published: October 2024

BackgroundCardiovascular diseases (CVD) pose a significant threat to human health due to their high mortality and morbidity rates. Despite advances in treatments, the prevalence and impact of cardiovascular disease continue to increase. Sodium-glucose transporter 2 inhibitors (SGLT2i), initially approved for the treatment of type 2 diabetes, have important research value and promising applications in reducing CVD risk, especially in heart failure (HF) and atherosclerosis patients with cardiovascular disease (ASCVD). This study aims to comprehensively review the latest progress, research trends, cutting-edge hot spots, and future development directions of SGLT2i in the field of CVD through bibliometric analysis.MethodsArticles related to MSCs in cardiovascular diseases were sourced from the Web of Science. The bibliometric analysis was conducted using CiteSpace and VOSviewer, and a knowledge map was created based on the data obtained from the retrieved articles.ResultsIn this article, we screened 3,476 relevant studies, including 2,293 articles and 1,183 reviews. The analysis found that the number of papers related to the application of SGLT2i in CVD has generally increased, peaking in 2022. The United States and China contributed the largest number of papers, with the United States accounting for 36.97% of the total and also ranking first in terms of the number of citations. However, China’s high-quality papers are slightly lacking and need further improvement. Keyword analysis showed that empagliflozin, dapagliflozin, diabetes, and heart failure were the most common terms, reflecting the main research interests in currently published papers in this field.ConclusionBibliometric analysis showed a robust and growing interest in the application of SGLT2i for treating CVD. By summarizing the latest progress of SGLT2i in the field of CVD, exploring research hotspots, and looking forward to future research development trends, this article provides valuable insights for thinking about research prospects.
Antidiabetic potential of Lavandula stoechas aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects
Authors: Elrherabi Amal , Abdnim Rhizlan , Loukili El Hassania , Laftouhi Abdelouahid , Lafdil Fatima Zahra , Bouhrim Mohamed , Mothana Ramzi A. , Noman Omar M. , Eto Bruno , Ziyyat Abderrahim , Mekhfi Hassane , Legssyer Abdelkhaleq , Bnouham Mohamed 
Published: October 2024

BackgroundWith the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. Lavandula stoechas, a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabetes. This study aims to evaluate the pharmacological potential of L. stoechas aqueous extract (AqLs) by assessing its lipase inhibition antioxidant and anti-inflammatory activities, identifying phenolic compounds, and examining its efficacy in reducing diabetic complications.MethodsThe pharmacological potential of L. stoechas aqueous extract was investigated using in vitro assays. The inhibitory effect on pancreatic lipase, antioxidant power (FRAP), and anti-inflammatory activity (albumin denaturation method) was assessed. High-performance liquid chromatography (HPLC) analysis identified phenolic compounds. Additionally, albumin glycation was evaluated by estimating fructosamine, carbonyl groups, and amyloid β-structures to assess efficacy in mitigating diabetic complications.ResultsThe extract demonstrated concentration-dependent inhibition of pancreatic lipase (IC50 = 0.132 ± 0.006 mg/mL), potent antioxidant activity (IC50 = 604.99 ± 1.01 μg/mL), and dose-dependent anti-inflammatory effects (IC50 = 207.01 ± 34.94 mg/mL). HPLC analysis revealed phenolic compounds: naringin (38.28%), syringic acid (25.72%), and cinnamic acid (15.88%) were the most abundant, with 4-hydroxybenzoic acid, hydrated catechin, and catechin ranging from 9.60% to 5.24%, and p-coumaric acid (1.73%). Furthermore, the extract inhibited albumin glycation and fructosamine production, suggesting efficacy in mitigating diabetic complications.ConclusionThese findings highlight the multifaceted pharmacological potential of L. stoechas aqueous extract in T2D management, suggesting that this plant can be highly beneficial for diabetic individuals.
Rehmannia glutinosa DC.-Lilium lancifolium Thunb. in the treatment of depression: a comprehensive review and perspectives
Authors: Wang ZongHao , Wang Xiaoyu , Mou Xiangyu , Wang ChangLin , Sun Ya , Wang JieQiong 
Published: October 2024

BackgroundIn recent years, the incidence of depression, recognized as a serious psychological disorder, has escalated rapidly. Rehmannia glutinosa DC. (Scrophulariaceae; Rehmanniae Radix, Crude drug) and Lilium lancifolium Thunb. (Liliaceae; Lilii bulbus, Crude drug) constitute a classic anti-depressant combination, exhibiting pharmacological effects that include anti-depressive, anti-anxiety, and anti-inflammatory properties. Current clinical studies have demonstrated that Baihe Dihuang Decoction, a traditional Chinese herbal compound, is effective in treating depression. However, the majority of scholars have predominantly examined Rehmannia glutinosa and Lilium in isolation, and a comprehensive elucidation of their principal active metabolites and pharmacological mechanisms remains lacking.MethodsA comprehensive literature search was conducted as of 29 September 2024, utilizing databases such as PubMed, CNKI, Wanfang Data, Baidu Scholar, and Google Scholar. Additionally, classical texts on Chinese herbal medicine, the Chinese Pharmacopoeia, as well as doctoral and master’s theses, were included in the collected materials. The search employed specific terms including “R. glutinosa,” “Lilium,” “Baihe Dihuang decoction,” “application of Baihe Dihuang decoction,” “pathogenesis of depression,” and “pharmacological action and mechanism of depression.ResultsThis paper reviewed the traditional applications and dosages of the R. glutinosa-Lilium as documented in Chinese medical classics, thereby establishing a foundation for the contemporary development and clinical application of the classical formula Baihe Dihuang Decoction. Additionally, recent years have seen a comprehensive review of the pharmacological effects and mechanisms of R. glutinosa-Lilium and its principal metabolites in the context of depression.ConclusionThis paper has reviewed the active metabolites of R. glutinosa-Lilium and demonstrated its efficacy in the treatment of depression, as well as its role in modulating the underlying mechanisms of the disorder. The findings aim to serve as a reference for further research into the mechanisms of depression, its clinical applications, and the development of novel therapeutic agents.
Analysis of the mechanical properties and micro-reinforcement mechanisms of loose accumulated sandy soil improved with polyvinyl alcohol and sisal fiber
Authors: Sang Ding , Wang Peiqing , Chen Liang , Zhang Wengang , Liu Zhen , Wang Qi 
Published: October 2024

As one of the world’s most fragile and sensitive ecological regions, Xizang risks significant environmental damage from using traditional materials, including cement and lime, to improve and reinforce loose accumulated sandy soil slopes. To address this issue, this study utilized a low-concentration biodegradable polyvinyl alcohol (PVA) solution combined with sisal fibers (SFs) to stabilize loose accumulated sand in southeastern Xizang. A series of physical, mechanical, and microscopic analyses was conducted to evaluate the properties of the treated sand. The results indicated the following. 1) The stress-strain curves of the improved samples exhibited an elastic-plastic relationship. Failure was observed in two stages. At a strain of 3% or less, the samples demonstrated elastic deformation with a linear increase in stress, whereas the deviator stress increased rapidly and linearly with an increase in axial strain. Once the strain exceeded 3%, the deformation became plastic with a nonlinear increase in the stress-strain relationship, and the growth rate of the deviator stress gradually decreased and leveled off. 2) Under varying confining pressure conditions, the relationship curve between the maximum (σ1-σ3)max∼σ3 for both untreated loose accumulated sandy soil and soil improved with the PVA solution, and the sisal fiber was approximately linear. 3) The SFs created a skeletal-like network that encased the soil particles, and the hydroxyl functional groups in the PVA molecules bonded with both the soil particles and the fiber surface, thereby enhancing the interfacial properties. This interaction resulted in a tighter connection between the soil particles and SFs, which improved the stability of the structure. 4) The incorporation of a PVA solution and SFs significantly enhanced the mechanical strength and deformation resistance of the loose accumulated sandy soil. The optimal ratio for the improved soil was SP = 3% and SL = 15 mm, which increased the cohesion from 24.54 kPa in untreated loose accumulated sandy soil to 196.03 kPa. These findings could be applied in engineering practices to improve and reinforce loose accumulated sandy soil slopes in southeastern Xizang and provide a theoretical basis for such applications.
Depression and associated factors among patients with type 2 diabetic mellitus in Ethiopia: a cross sectional study
Authors: Dukato Amanuel , Beyamo Abera , Habte Hailegebireal Aklilu , Teklehaimanot Wegayehu Zeneb , Ayfokru Abatwoy , Alemnew Metages , Birhanu Abate Daniel , Abemie Worku , Mengistu Bethlehem Taye , Ayehu Dessie Yihenew , Mengstie Leweyehu Alemaw , Girma Bekahegn 
Published: October 2024

BackgroundDepression is a significant public health concern in both developed and developing countries. The burden of depression is particularly high among patients with chronic illnesses in developing countries, creating a dual challenge for both patients and the community. However, depression goes undiagnosed in 50%-75% of patients with chronic conditions such as diabetes mellitus. Additionally, there is limited information about the prevalence of depression among diabetic patients in Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of depression among type 2 diabetic patients in Ethiopia.MethodAn institution-based cross-sectional study was conducted on 376 randomly selected type 2 diabetic patients. Data were collected through face-to-face interviews and from patients’ follow-up records. The data were entered into EpiData version 4.6 and analyzed using STATA 14. Bivariable and multivariate logistic regression analyses were employed to identify associated factors. Variables with a p-value of less than 0.25 in the bivariable analysis were selected for multivariate logistic regression. Model fitness was assessed using Hosmer-Lemeshow’s test, and associations were reported using adjusted odds ratios with 95% confidence intervalsResultsIn this study, the prevalence of depression among type 2 diabetic patients was found to be 69.72% (95% CI: 64.75, 74.27). Three factors were significantly associated with depression in these patients: the duration of diabetes mellitus since diagnosis [AOR: 1.17; 95% CI (1.02, 1.34)], glycaemic control [AOR: 1.8; 95% CI (1.09, 3.01)] and cigarette smoking [AOR: 2.18; 95% CI (1.07, 4.46)].ConclusionThe prevalence of depression among type 2 diabetic patients was high. The Federal Ministry of Health, stakeholders, and the Ethiopian Diabetes Association should collaborate to reduce this burden. Mental health assessment and treatment should be integrated into chronic care follow-up services. Additionally, healthcare providers should closely monitor and counsel patients who smoke and those with poor glycemic control.
Incivility, bullying, and poor health and well-being among students: a Swedish national study in higher education institutions
Authors: Mensah Aziz , Toivanen Susanna , Björklund Christina 
Published: October 2024

ObjectiveExposure to incivility and bullying among students in higher education institutions may have detrimental health and well-being outcomes. Nevertheless, the mechanism and interconnected pathways through which incivility and bullying are linked with poor health and well-being remain largely unexplored. The aim of this study is to investigate the relationships between incivility, bullying, and poor health and well-being among students in higher education institutions in Sweden, and whether gender influences these relationships. Furthermore, we examine whether bullying plays a mediating role in the relationship between incivility and poor health and well-being.MethodsWe analyzed a cross-sectional dataset of students drawn from 38 universities that are members of the association of Swedish higher education institutions. The data were collected from May to July 2021, covering 11,162 women and 6,496 men. Confirmatory factor analysis and structural equation modeling (SEM) were utilized to estimate the relationships between incivility, bullying, and poor health and well-being. Additionally, multigroup analysis was applied to estimate the interactive effect of gender in these relationships.ResultsReports of both incivility and bullying were more prevalent among women than men. The results showed that incivility had direct relationships with both bullying β=0.578,p<0.01 and poor health and well-being β=0.301,p<0.01. However, the relationship between bullying and poor health and well-being was not significant. There were statistically significant gender differences in the relationships between incivility, bullying, and poor health and well-being (Δχ223=179.18,p<0.01). Nevertheless, bullying did not significantly mediate the relationship between incivility and poor health and well-being.ConclusionThe current study demonstrates that governments, university authorities, and policymakers must consider gender differences in incivility and bullying when developing policies and interventions intended to reduce these kinds of behaviors in organizations.
Associations between Recession hardships and subjective and objective sleep measures in the midlife in the United States study: race and gender differences
Authors: Bhat Aarti C. , Diaz Jose A. , Lee Sun Ah , Almeida David M. , Lee Soomi 
Published: October 2024

ObjectivesThis study investigates the associations of retrospective reports of Recession hardships with 10-year changes in subjective and objective indicators of sleep, and whether these associations differ by race and gender.MethodsFive hundred and one adults (14.57% Black; 54.49% female) from the Midlife in the United States (MIDUS) study reported on the subjective Pittsburgh Sleep Quality Index (PSQI) across two waves (pre-Recession, collected 2004–2009; post-Recession, collected 2017–2022), as well as Recession hardships since 2008. A sub-sample of 201 adults (25.37% Black; 58.21% female) provided objective actigraphy-measured sleep data (total sleep time, sleep onset latency, and sleep efficiency) across the two waves.ResultsDescriptive analyses revealed Black participants had higher average Recession hardships, poorer post-Recession PSQI scores, and poorer post-Recession actigraphy sleep quantity and quality compared to white participants. Females had higher average Recession hardships compared to males; and reported poorer post-Recession PSQI, but had better objective post-Recession sleep quantity and quality compared to males. Regression models showed Recession hardships (across overall events, and sub-domains of financial and housing hardships) were associated with poorer PSQI and actigraphy-measured sleep efficiency following the Recession, adjusting for sociodemographic covariates, corresponding pre-Recession sleep variables, and pre-Recession chronic conditions. There was no evidence for significant moderation by race on sleep outcomes. However, gender moderation indicated associations between housing hardships and poorer actigraphy-measured sleep efficiency were more apparent for females than for males.ConclusionsFindings indicate that Recession hardships (particularly in financial and housing domains) may be manifested in poor sleep. Racial and gender groups may have differential exposure and sleep-related reactivity to Recession hardships.
Molecular Cloning, Characterization, and Application of a Novel Multifunctional Isoamylase (MIsA) from Myxococcus sp. Strain V11
Authors: Feng Siting , Zhang Weiqi , Liu Jun , Hu Yusen , Wu Jialei , Ni Guorong , Wang Fei 
Published: October 2024

A novel multifunctional isoamylase, MIsA from Myxococcus sp. strain V11, was expressed in Escherichia coli BL21(DE3). Sequence alignment revealed that MIsA is a typical isoamylase that belongs to glycoside hydrolase family 13 (GH 13). MIsA can hydrolyze the α-1,6-branches of amylopectin and pullulan, as well as the α-1,4-glucosidic bond in amylose. Additionally, MIsA demonstrates 4-α-D-glucan transferase activity, enabling the transfer of α-1,4-glucan oligosaccharides between molecules, particularly with linear maltooligosaccharides. The Km, Kcat, and Vmax values of the MIsA for amylopectin were 1.22 mM, 40.42 µmol·min–1·mg–1, and 4046.31 mM·min–1. The yields of amylopectin and amylose hydrolyzed into oligosaccharides were 10.16% and 11.70%, respectively. The hydrolysis efficiencies were 55%, 35%, and 30% for amylopectin, soluble starch, and amylose, respectively. In the composite enzyme hydrolysis of amylose, the yield of maltotetraose increased by 1.81-fold and 2.73-fold compared with that of MIsA and MTHase (MCK8499120) alone, respectively.