bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent developments in China’s biopharmaceutical industry (2012-2017)
Authors: Conlé Marcus 
Published: June 2019

Purpose
The paper aims to take stock of China’s recent biopharmaceutical industry development by analyzing product innovation and changes in the firms’ product portfolios during the five-year period between 2012 and 2017.

Design/methodology/approach
The paper introduces a classification of biopharmaceutical products. By applying the classification to the product data of China’s drug regulator, the CFDA, it becomes possible to trace the developments within the sector by looking at changes in the number of firms within each subgroup and changes in the number of subgroups in which each firm is involved. The classification allows an evaluation of the latest product innovation achievements.

Findings
The paper demonstrates a mild shakeout of firms in the relatively long-existing domestic market segments, a trend toward more specialized product portfolios and an enduring prevalence of innovation strategies aimed at exploiting relatively unpopulated domestic market niches instead of pioneering entirely new products. Especially the capability of upgrading to second-generation protein therapeutics has become a key criterion for separating the wheat and the chaff in China’s domestic sector. The paper moreover points out the relevance of acquisitions as a corporate growth strategy.

Research limitations/implications
The research does not consider complementary indicators, product pipelines in particular. Future research should compare patterns across emerging economies.

Originality/value
The paper is unique in using the CFDA database for systematic academic research on (bio)pharmaceutical innovation and in introducing a biopharmaceutical product classification to trace innovative activities and changes in corporate product portfolios over time.
Empowerment in service recovery: the role of self-regulation process of frontline employee
Authors: Zhang Mo , Geng Ruoqi 
Published: June 2019

PurposeIn accordance with the commitment–trust theory, employee attitudes and behaviours mediate the impact of empowerment on service recovery performance. The purpose of this paper is to extend the self-regulating process model and develop a structural framework that combines empowerment, self-regulation mechanisms (service recovery awareness, job engagement and emotional exhaustion) and post-recovery satisfaction. This framework explores how empowerment can lead to action of frontline employees (FLEs) in service recovery.Design/methodology/approachThe authors test the hypotheses by investigating 290 pairs of FLEs and customers, who have service failure experience in the express mail industry, using structure equation modelling.FindingsThe findings show that empowerment enhances both service recovery awareness and job engagement. On the one hand, service recovery awareness has a positive impact on emotional exhaustion, which has a negative impact on post-recovery satisfaction. On the other hand, job engagement has a positive impact on performance. These results provide the whole picture of the double-edged effects of empowerment on FLEs in service recovery.Practical implicationsThis paper indicates that managers should re-consider approaches to empowerment based on self-regulation process to enhance performance following service failure.Originality/valueThis study explores the dark side of empowerment in service recovery from a self-regulation perspective.
Phytochemicals derived from soya bean husk exert hypoglycemic and anti-adipogenic properties in cell culture models
Authors: Tan Seok-Tyug , Ismail Amin , Hamid Muhajir , Chong Pei-Pei , Sun Jian , Tan Seok-Shin 
Published: June 2019

Purpose
Literature has shown that phenolic acids and flavonoids are bearing with hypoglycemic and anti-adipogenic properties. Therefore, this study aims to evaluate the possibility of phenolic-rich soya bean husk powder extract (SHPE) in combating diabetes and obesity using in vitro models.

Design/methodology/approach
The hypoglycemic properties were evaluated by determining the ability of SHPE (25-100 µg/mL) in inhibiting a-amylase and a-glucosidase enzymes and in triggering insulin secretion in BRIN-BD11 cells. Murine 3T3-L1 adipocytes were used for evaluating the anti-adipogenic properties of SHPE through the determination of relative lipid accumulation, triglyceride content and glycerol-3-phosphate dehydrogenase (GPDH) activity.

Findings
The hypoglycemic properties of SHPE was in the dose-dependent manner, where 100 µg SHPE/mL exhibited a significant higher (p < 0.05) a-amylase inhibitory activity (56.8 ± 0.11 per cent) and insulin secretion activity (0.73 ± 0.02 µg/l) against other concentrations. In contrast to the aforementioned findings, a significant lower a-glucosidase inhibitory activity (52.0 ± 0.44 per cent) was also observed in 100 µg SHPE/mL. Nevertheless, findings revealed that all the SHPE were able to inhibit the activity of a-amylase and a-glucosidase and stimulated the insulin secretion in BRIN-BD11 cells. On the other hand, the anti-adipogenic properties of SHPE were in the reverse dose-dependent manner, where 100 µg SHPE/mL demonstrated a significant lower (p < 0.05) relative lipid accumulation (48.5 ± 0.03 per cent), intracellular triglyceride content (5.7 ± 0.07 mg/dL) and GPDH activity (1.0 ± 0.01 mU/mL). These findings reflected that 100 µg SHPE/mL was a potent anti-adipogenic agent when compared with other concentrations. In conclusion, soya husk could emerge as a potential hypoglycemic and anti-adipogenic agents in in vitro models.

Originality/value
This was the first study to explore the effectiveness of phytochemicals derived from soya bean husk in ameliorating hyperglycemia and adipogenesis. Promising findings that derived from the present study could enable the scientists to re-evaluate the potential use of agricultural wastes, especially in the formulation of nutraceuticals.
In transitional periods how does bureaucracy work steadily?
Authors: Ahmed Nahla Mahmoud , Aref Alia Abd el Hamid 
Published: June 2019

PurposeThe purpose of this paper is to explain the issues and variables that influence the bureaucracy’s role and work in the transitional period, which is known with its complexity, uncertainty, instability, ambiguity and asymmetry. This paper highlights the transition from theoretical perspective, giving examples from the Polish experience in transition.Design/methodology/approachThis paper describes the changing roles of public bureaucracies in transitional periods by highlighting their ecology with the transitional period and analyzing the determinants of bureaucracy’s role and functions in terms of participation in policy-making policies, providing consultations to executives and elected officials, working as a mediator in communication and acting as an active participant in the development process giving examples from Poland. Finally, it highlights the way the bureaucracy manages its functions and the internal and external variables that constitute various levels affecting this role in the transition.FindingsBureaucracy is supposed to function naturally and stably in an unstable environment (transition) as its success in doing these functions and helping the new regime to exceed the transition and achieve its goals depends on many variables (bureaucracy capabilities and skills, history, power, experience, the nature of politics and bureaucratic functions, political support, policy environment, knowledge, cohesion, etc.). Most of these variables were demonstrative in the case of Poland.Originality/valueThis paper will be useful for scholars and policymakers interested in public administration role in the time of transition, especially countries that recently have been experiencing the transition.
Do environmental responsibility views influence investors’ use of environmental performance and assurance information?
Authors: Dilla William , Janvrin Diane , Perkins Jon , Raschke Robyn 
Published: June 2019

PurposeThe purpose of this study is to investigate whether investor views regarding the benefits of corporate environmental responsibility moderate the influence of environmental performance and assurance information on their judgments. Specifically, the authors examine the effects of two broad views: environmental responsibility is more important than financial performance, regardless of investment returns (i.e. environmental responsibility importance) and positive environmental performance will increase investment returns (i.e. environmental performance return).Design/methodology/approachNonprofessional investors completed an online study where environmental performance (high or low) and assurance on environmental performance information (present or absent) were varied. Participants’ corporate environmental responsibility views were assessed using a series of questions adapted from Cheahet al.’s (2011) study.FindingsEnvironmental performance and assurance information had a greater influence on the investment judgments of investors with strong environmental responsibility views. In contrast, participants’ environmental performance return views did not moderate the influence of environmental performance and assurance information on their judgments. Supplemental analysis indicates that these contrasting results are due to the fact that the two investor views have differing influences on the relative importance that investors place on financial vs environmental performance information.Research limitations/implicationsThis study presented participants with summarized financial and environmental performance information to maintain scale compatibility between financial and environmental measures. However, the information was presented in a format similar to those used by online brokerages.Practical implicationsThis study suggests that financial statement preparers should consider investors’ views regarding the importance and value of environmental performance information when making decisions to disclose and obtain assurance on this information.Social implicationsStandard setters should consider individual differences among investors when developing guidance regarding the disclosure and assurance of environmental performance information.Originality/valueThere is limited prior research which examines how investors’ views of the importance of environmental performance information may influence investment judgments. This research indicates that the strength of investors’ environmental responsibility importance moderates the previously reported influence of environmental performance and assurance information on investment judgments.
Bank-based and market-based development and economic growth: an international investigation
Authors: Boadi Isaac , Osarfo Daniel , Boadi Perpetual 
Published: June 2019

PurposeThe purpose of this paper is to investigate the relative impact of bank-based and market-based financial developments on economic growth from 1984 to 2015, using 60countries.Design/methodology/approachThis study uses fixed effect and generalized method of moments (GMM) to investigate the relative impact of bank-based and market-based financial developments on economic growth from 1984 to 2015, using 60 countries. The study further controls regional effects and the Asian crisis, as well as the global economic crisis.FindingsThe empirical results of the study revealed that market-based development positively affects economic growth. Besides, market-based financial development indirectly promotes investment, which has the potential to strongly enhance growth. The findings of this study, therefore, provide more support to pro-market-based financial development policies in these regions. Interestingly, bank-based development has no direct impact on development, but indirectly encourages investment, which also promotes growth.Originality/valueThis paper is the first of its kind to empirically examine fixed effect and GMM to investigate the relative impact of bank-based and market-based financial developments on economic growth from 1984 to 2015, using 60 countries.
Development of an optical tyrosinase biosensor (TCA) for detection of “Parathion-Methyl”
Authors: Polatoğlu İlker , Cakıcıoglu Ozkan Fehime 
Published: June 2019

Purpose
This paper aims to present a novel and cost-effective optical biosensor design by simple preparation method for detection of “parathion-methyl,” which is a model pesticide pose to public health and the environment.

Design/methodology/approach
The optical enzyme biosensor (TCA) for detection of pesticide “parathion-methyl” was developed on the basis of immobilization of tyrosinase enzyme on chitosan film by adsorption technique. The analytic performance of TCA was investigated by measuring its activity with Ultraviolet (UV) visible spectrophotometer.

Findings
Uniform porous network structure and protonated groups of chitosan film provided a microenvironment for tyrosinase immobilization evident from Fourier transform infrared (FTIR) spectroscopy and Atomic Force Microscopy analysis. TCA has a wide linear detection range (0-1.03 µM) with high correlation coefficient and it can detect the parathion-methyl concentration as low as 159 nM by noncompetitive inhibition kinetics. Using the TCA sensor both for ten times and at least 45 days without a significant loss in its activity are the indicators of its good operational and storage stability. Moreover, TCA can be applicable to tap water, providing a promising tool for pesticides detection.

Originality/value
This is the first time to use the in situ analytical technique that can improve the performance of optical enzyme sensor provided to control the pesticide residue better with respect to traditional techniques. The effect of organic solvents on the performance of optical enzyme biosensor was investigated. Inhibition kinetic of the solvents rarely encountered in literature was also studied besides the pH and temperature tolerance of the optical biosensor.
A paradox of place: civic education in the rural south
Authors: Moffa Eric 
Published: June 2019

Purpose
Due to the complexities of place and the limited knowledge of citizenship education in rural contexts, the purpose of this paper is to examine civics teachers’ perceptions of place in rural schools and its influence on their decision making about the curriculum.

Design/methodology/approach
A qualitative case study design was utilized. Four 12th grade civics teachers were sampled across three rural schools in a southern state. Data came from interviews, classroom observations and teaching artifacts. A constant comparison method of data analysis led to the emergence of a major theme: the paradoxical treatment of place in civic education in rural schools.

Findings
Participants implemented place-based pedagogies while simultaneously promoting the narrative that students leave their home communities after graduation due to limited post-secondary opportunities (i.e. place-based learning for future (dis)placements). Participants reconciled leaving narratives and the displaced futures of students by emphasizing “the basics” devoid of place.

Originality/value
The paradoxical treatment of place, as influenced by teachers’ perceptions and civic sensibilities, contrasted with theoretical perspectives on place-based education that emphasize inhabiting and attending to place. Findings suggest the need to prepare rural civics teachers for place-conscious civic pedagogies to challenge paradoxical treatments of place and engender democratic investments in rural communities.
Examining preservice teachers’ thinking about teaching first grade economics through inquiry
Authors: Bauml Michelle 
Published: June 2019

Purpose
In recent years, the field of social studies education has seen renewed interest in using inquiry to teach intradisciplinary concepts and skills. However, prospective primary grade teachers may have few (if any) opportunities to observe classroom teachers modeling inquiry during field placements. Methods courses provide fitting contexts in which to introduce preservice teachers (PSTs) to inquiry as a basis for intellectually challenging, meaningful social studies instruction. The purpose of this paper is to utilize a published inquiry curriculum developed for the New York Social Studies Toolkit (NYSST) Project as a tool to explore PSTs’ thinking about teaching first grade economics.

Design/methodology/approach
This qualitative study utilized focus groups with two groups of early childhood PSTs enrolled in a social studies methods course (n=28). Secondary data sources included PSTs’ handwritten comments on hard copies of the inquiry curriculum and the researcher’s analytic memos.

Findings
In the process of critiquing curriculum during focus group interviews, PSTs concentrated on the proposed tasks, evaluated those tasks for their potential to affect children’s understanding, and suggested new activities that would promote more active student engagement. Participants recognized the significance of children’s prior knowledge and were sensitive to students’ family values, although they underestimated young children’s capacity for robust discussion and intellectually challenging content.

Originality/value
This study is unique in its use of a published NYSST Project inquiry to explore how PSTs make sense of new curriculum. Its attention to PST education for primary grades contributes to elementary social studies literature. Additionally, this study addresses a general concern in teacher education about the need for PSTs to develop skills in interpreting and adapting curriculum materials. Findings suggest that engaging PSTs in discussions about social studies curriculum can help teacher educators identify latent learning goals for their courses that may be overlooked or assumed unnecessary.
Integrative ambidexterity: one paradoxical mode of learning
Authors: Cunha Miguel Pina e , Bednarek Rebecca , Smith Wendy 
Published: June 2019

PurposeOrganizational ambidexterity brings together the paradoxical tensions between exploration and exploitation. Embracing such paradoxical tensions depends on both separating the poles to appreciate their distinct elements and integrating them to appreciate their synergies. This paper explores integrative ambidexterity that focuses on the synergies between exploration and exploitation and theorizes these as a single, paradoxical mode of learning.Design/methodology/approachThe authors provide conceptual commentary that aims to expand the attention within the ambidexterity literature from emphasizing separation to further accommodating integration.FindingsThe authors outline that attention to separating exploration and exploitation needs to be complemented with a focus on integration, hence, the notion of integrative ambidexterity.Research limitations/implicationsThe authors surface three processes that advance integrative ambidexterity – novelty via memory; agility via focus; and the potential for improvisation. Together, these dynamics enable organizations to achieve an alternative approach to learning and adaptation.Practical implicationsUnderstanding “integrative ambidexterity,” stressing the synergies between exploration and exploitation, extends the understanding of the nature and approaches to creating learning organizations. The authors three practices offer a potential blueprint to do so.Originality/valuePrevious scholarship emphasized how leaders can separate exploration and exploitation by allocating these learning modes to distinct organizational units or addressing them in different time horizons. However, extant authors have less insight about the integration and synergies between exploration and exploitation, and the organizational factors that advance such integration.
When the larger objective matters more: support workers’ epistemic and deontic authority over adult service‐users
Authors: Antaki Charles , Webb Joseph 
Published: June 2019

AbstractWe report on how support workers sometimes over‐ride the wishes of people living with cognitive impairments. This can happen when they are both involved in some project (such as an institutionally‐managed game, a physical journey, an educational activity and so on). The support worker might use their deontic authority (to propose, decide or announce future actions) to do things that advance the over‐arching project, in spite of proposals for what are cast as diversions from the person with impairments. They might also use their epistemic authority (their greater knowledge or cognitive capacity) to trump their clients’ choices and preferences in subordinate projects. Not orienting to suggested courses of actions is generally interactionally dispreferred and troublesome, but, although the providers do sometimes orient to their actions as balking their clients’ wishes, they usually do not, and encounter little resistance. We discuss how people with disabilities may resist or palliate such loss of control, and the dilemmas that support staff face in carrying out their duties.
Economic fluctuations, volatility changes and the role of government spending in China: A structural analysis
Authors: Hsu Minchung , Lee Junsang , Zhao Min 
Published: June 2019

AbstractWe study the economic fluctuations in China by using a standard neoclassical general equilibrium model to provide a structural analysis. We have carefully constructed measurements for economic variables from Chinese data to be consistent with the literature. We show that the government spending behaviour plays an important role in accounting for the changes in the pattern of both absolute and relative volatilities. Although we find that a general moderation in economic fluctuations after 1978 can be largely explained by the total factor productivity (TFP) process, TFP itself cannot explain the change in the pattern of relative volatilities. We show that policy changes in government spending can account for the relative volatility divergency. Counterfactual experiments are also provided to discover the role of each factor in explaining the economic fluctuations in China.
Evaluation of the acaricidal activity of 63 commercialized pesticides against Haemaphysalis longicornis (Acari: Ixodidae)
Authors: Park Geun‐Ho , Kim Hyun Kyung , Lee Wook‐Gyo , Cho Shin‐Hyeong , Kim Gil‐Hah 
Published: June 2019

AbstractThe acaricidal activity and residual effects of 63 commercialized pesticides against the Cheongju strain of Haemaphysalis longicornis in Korea were examined. Twenty‐two pesticides (4 carbamates, 5 organophosphates, 10 pyrethroids, 1 amitraz, 1 diamide, and 1 unclassified pesticide) caused greater than 80% mortality in H. longicornis adults under laboratory conditions using the spray method. These 22 pesticides were used to treat grassland under field conditions for investigation of the residual effects, and 100% mortality in H. longicornis adults was observed with all the carbamates (carbosulfan, benfuracarb, fenobucarb, and carbaryl) and γ‐cyhalothrin after 3 days of pesticide treatment. γ‐Cyhalothrin exhibited 56.7% mortality after 10 days of treatment, which was the longest residual effect of treated grass on H. longicornis adults. With regard to the residual effects on H. longicornis under field conditions, most of the 22 pesticides exhibited higher mortality in nymphs than in adults. In particular, benfuracarb exhibited 96.7% acaricidal activity until 10 days after treatment.These results indicate that carbamates are highly likely to be available under field conditions and, based on this preliminary data, could be used for the control of H. longicornis adults and nymphs.