bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Adjusting the One‐Sided Hodrick–Prescott Filter
Authors: WOLF ELIAS , MOKINSKI FRIEDER , SCHÜLER YVES 
Published: November 2024

AbstractWe show that one should not use the one‐sided Hodrick–Prescott (HP‐1s) filter as the real‐time version of the two‐sided HP (HP‐2s) filter: First, in terms of the extracted cyclical component, HP‐1s fails to remove low‐frequency fluctuations to the same extent as HP‐2s. Second, HP‐1s dampens fluctuations at all frequencies—even those it is meant to extract. As a remedy, we propose two small adjustments to HP‐1s, aligning its properties closely with those of HP‐2s: (i) a lower value for the smoothing parameter and (ii) a multiplicative rescaling of the extracted cyclical component. For example, for HP‐2s with (value of smoothing parameter), the adjusted one‐sided HP filter uses and rescales the extracted cyclical component by a factor of 1.1513. Using simulated and empirical data, we illustrate the relevance of these adjustments. For instance, financial cycles may appear to be 72% more volatile than business cycles, where, in fact, volatilities differ only marginally.
Telehealth delivery of GenerationPMTO in the public mental health system: A pragmatic, noninferiority study
Authors: Holtrop Kendal , Piehler Timothy F. , Gray Luann J. 
Published: November 2024

AbstractTelehealth is a promising means for expanding access to mental health treatment. Yet, more research is needed to ensure that telehealth service delivery is no less effective than in‐person treatment in real‐world service delivery contexts. In the current study, we compared telehealth delivery of the GenerationPMTO parenting intervention to in‐person delivery in the context of the public mental health system. Using a noninferiority approach with a sample of n = 1452 caregivers, we found telehealth delivery to be noninferior to in‐person delivery on all caregiver outcomes: parenting practices, parenting confidence, and caregiver depressive symptoms. We were unable to conclude that telehealth delivery was noninferior to in‐person delivery for child behavior problems. Our findings add to the literature suggesting the utility of using telehealth to provide services to families—particularly for delivering evidence‐based parenting interventions to enhance caregiver outcomes. Implications for couple and family therapy are discussed.
Physical exercise halts further functional decline in an animal model for Charcot–Marie–Tooth disease 1X at an advanced disease stage
Authors: Klein Dennis , Yépez Maria Grijalva , Martini Rudolf 
Published: November 2024

AbstractBackground and AimsCharcot–Marie–Tooth (CMT) type 1 neuropathies are the most common inherited diseases of the peripheral nervous system. Although more than 100 causative genes have been identified so far, therapeutic options are still missing. We could previously identify that early‐onset physical exercise (voluntary wheel running, VWR) dampens peripheral nerve inflammation, improves neuropathological alterations, and clinical outcome in Cx32def mice, a model for CMT1X. We here investigate the clinical and histopathological effect of late‐onset exercise in Cx32def mice at an advanced disease stage.MethodsNine‐month‐old Cx32def mice were allowed to run for 4 days/week on a commercially available running wheel for 3 months, with timely limited access to running wheels, representing a running distance of ~2000 m. Control mutants had no access to running wheels. Afterward, mice were investigated by distinct functional tests and by immunohistochemical and electron microscopical techniques.ResultsWe found that late‐onset physical exercise (late VWRlim) prevented the robust functional decline in 12‐month‐old Cx32def mice. This was accompanied by improved neuromuscular innervation of distal muscles and axonal preservation in femoral quadriceps nerves. In contrast to a “pre‐symptomatic” start of physical exercise in Cx32def mice, late‐onset VWR did not alter nerve inflammation and myelin thickness at 12 months of age.InterpretationWe conclude that VWR has robust beneficial effects on nerve function in Cx32def mice, even when applied at a progressed disease stage. These results have important translational implications, suggesting that physical exercise might be an effective treatment option for CMT1 patients, even when disease symptoms have already progressed.
Long‐term safety and tolerability of hyaluronidase‐facilitated subcutaneous immunoglobulin 10% as maintenance therapy for chronic inflammatory demyelinating polyradiculoneuropathy: Results from the ADVANCE‐CIDP 3 trial
Authors: Hadden Robert D. M. , Andersen Henning , Bril Vera , Basta Ivana , Rejdak Konrad , Duff Kim , Greco Erin , Hasan Shabbir , Anderson‐Smits Colin , Ay Hakan 
Published: November 2024

AbstractBackground and AimsHyaluronidase‐facilitated subcutaneous immunoglobulin (fSCIG) consists of subcutaneous human immunoglobulin G (IgG) 10% with recombinant human hyaluronidase (rHuPH20) and can be administered at the same dose and interval as intravenous IgG (IVIG). fSCIG recently received US approval as maintenance therapy for adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and European approval for adults and children with CIDP after stabilization with IVIG.MethodsADVANCE‐CIDP 3 (NCT02955355) was an open‐label long‐term extension of the Phase 3 double‐blind randomized placebo‐controlled ADVANCE‐CIDP 1 study (NCT02549170) that examined fSCIG safety and efficacy as maintenance CIDP therapy. Primary outcomes were safety, tolerability, and immunogenicity. Efficacy was an exploratory outcome.ResultsThe study provided 220 patient‐years of follow‐up data from 85 patients. Median (range) exposure was 33 (0–77) months. Patients received fSCIG every 4 weeks (88.2%) or every 3 weeks (11.8%). Median (range) 4‐weekly IgG dose equivalent was 64.0 (28.0–200.0) g. Mean (standard deviation) infusion duration was 135.5 (62.8) minutes. Most adverse events (AEs) were mild or moderate and self‐limiting. Of the 1406 AEs, only 48 were severe and 30 were serious. fSCIG‐related AEs (n = 798) included infusion site reactions such as pain, redness, and pruritus. Three infusions (0.1%) were reduced in rate, interrupted, or stopped due to intolerability. Relapse occurred in 10 of 77 patients (13.0%); annual relapse rate was 4.5%. An anti‐rHuPH20 antibody titer ≥1:160 was detected in 14 of 84 patients (16.7%); patients who tested positive (≥1:160) had similar relapse rates versus those who tested negative (16.7% vs. 12.3%, respectively).InterpretationADVANCE‐CIDP 3 demonstrated favorable fSCIG long‐term safety and tolerability consistent with its established safety profile, and a low relapse rate, supporting use as maintenance CIDP treatment.
Health literacy profiles in kidney transplanted patients: A cluster analysis
Authors: Vidnes Tone Karine , Wahl Astrid Klopstad , Larsen Marie Hamilton , Meyer Käthe Birgitte , Hermansen Åsmund , Andersen Marit Helen 
Published: November 2024

AbstractBackgroundHealth literacy is important in chronic conditions, such as kidney transplantation. Understanding patients' health literacy profiles can assist tailoring follow‐up and educational programmes to the health literacy needs of vulnerable kidney transplant recipients. This approach enabled us to cluster patients according to their profiles of challenges and strengths in different health literacy domains.ObjectivesThis study aimed to identify different health literacy profiles within kidney transplant recipients and what characterized the different profiles.DesignCross‐sectional study.ParticipantsOne hundred ninety‐five kidney transplanted recipients were included.MeasurementsWe used the self‐reported Health Literacy Questionnaire and analyzed using Ward's method (hierarchical cluster approach). We also collected background characteristics and clinical variables, including psychological distress (Hopkins Symptoms Checklist) and perceived health status (visual analogue scale, EuroQol‐5D).ResultsThe analysis revealed four clusters with substantial differences in health literacy profiles. One cluster's patients had the most challenges in all health literacy domains constituting 24% of the sample. Compared to the other three clusters, this cluster was associated with shorter duration of kidney disease, higher number of patients in dialysis before transplantation, higher percentage of male patients, lower number of kidneys from living donors, higher number of patients not working and higher representation of psychological distress. All four clusters reported the most challenges in the same domain: the ability to critically appraise health information.ConclusionIn kidney transplant recipients, profiling clusters with the Health Literacy Questionnaire and Ward's method aids in identifying health literacy needs in vulnerable groups, enabling transplant professionals to offer tailored health literacy support.
Changes to human sleep architecture during long‐duration spaceflight
Authors: Piltch Oliver , Flynn‐Evans Erin E. , Young Millennia , Stickgold Robert 
Published: November 2024

SummaryBoth rapid eye movement and non‐rapid eye movement sleep are important for cognitive function and well‐being, yet few studies have examined whether human sleep architecture is affected by long‐duration spaceflight. We recorded 256 nights of sleep from five crew members before (n = 112 nights), during (n = 83 nights) and after (n = 61 nights) ~6‐month missions aboard the Mir space station, using the Nightcap sleep monitor. We compared sleep outcomes (including total sleep time, efficiency, latency, rapid eye movement and non‐rapid eye movement) during spaceflight with those on Earth. We also evaluated longitudinal changes over time in space. We found that wakefulness increased by 1 hr in space compared with on Earth. Over time in space, rapid eye movement was initially reduced and then recovered to near preflight levels at the expense of non‐rapid eye movement sleep. Upon return to Earth, sleep architecture returned to preflight distribution. Our findings suggest that spaceflight may alter sleep architecture and should be explored further.
Disruptions and adaptations of an urban nutrition intervention delivering essential services for women and children during a major health system crisis in Dhaka, Bangladesh
Authors: Escobar‐DeMarco Jessica , Nguyen Phuong , Kundu Gourob , Kabir Rowshan , Ali Mohsin , Ireen Santhia , Ash Deborah , Mahmud Zeba , Sununtnasuk Celeste , Menon Purnima , Frongillo Edward A. 
Published: November 2024

AbstractSystematic crises may disrupt well‐designed nutrition interventions. Continuing services requires understanding the intervention paths that have been disrupted and adapting as crises permit. Alive & Thrive developed an intervention to integrate nutrition services into urban antenatal care services in Dhaka, which started at the onset of COVID‐19 and encountered extraordinary disruption of services. We investigated the disruptions and adaptations that occurred to continue the delivery of services for women and children and elucidated how the intervention team made those adaptations. We examined the intervention components planned and those implemented annotating the disruptions and adaptations. Subsequently, we detailed the intervention paths (capacity building, supportive supervision, demand generation, counselling services, and reporting, data management and performance review). We sorted out processes at the system, organizational, service delivery and individual levels on how the intervention team made the adaptations. Disruptions included decreased client load and demand for services, attrition of providers and intervention staff, key intervention activities becoming unfeasible and clients and providers facing challenges affecting utilization and provision of services. Adaptations included incorporating new guidance for the continuity of services, managing workforce turnover and incorporating remote modalities for all intervention components. The intervention adapted to continue by incorporating hybrid modalities including both original activities that were feasible and adapted activities. Amidst health system crises, the adapted intervention was successfully delivered. This knowledge of how to identify disruptions and adapt interventions during major crises is critical as Bangladesh and other countries face new threats (conflict, climate, economic downturns, inequities and epidemics).
Field Reduction of Ectomycorrhizal Fungi Has Cascading Effects on Soil Microbial Communities and Reduces the Abundance of Ectomycorrhizal Symbiotic Bacteria
Authors: Berrios Louis , Peay Kabir G. 
Published: November 2024

ABSTRACTSpecific interactions between bacteria and ectomycorrhizal fungi (EcMF) can benefit plant health, and saprotrophic soil fungi represent a potentially antagonistic guild to these mutualisms. Yet there is little field‐derived experimental evidence showing how the relationship among these three organismal groups manifests across time. To bridge this knowledge gap, we experimentally reduced EcMF in forest soils and monitored both bacterial and fungal soil communities over the course of a year. Our analyses demonstrate that soil trenching shifts the community composition of fungal communities towards a greater abundance of taxa with saprotrophic traits, and this shift is linked to a decrease in both EcMF and a common ectomycorrhizal helper bacterial genus, Burkholderia, in a time‐dependent manner. These results not only reveal the temporal nature of a widespread tripartite symbiosis between bacteria, EcMF and a shared host tree, but they also refine our understanding of the commonly referenced ‘Gadgil effect’ by illustrating the cascading effects of EcMF suppression and implicating soil saprotrophic fungi as potential antagonists on bacterial‐EcMF interactions.
Why Is It Too Cold? Towards a Mechanistic Understanding of Cold‐Water Pollution Effects on Recruitment of an Imperiled Warmwater Fish
Authors: Gilbert Eliza I. , Diver Tracy A. , Mussmann Steven M. , Saltzgiver Melody J. , Knight William K. , Durst Scott L. , Farrington Michael A. , Clark Barkalow Stephani L. , Tobler Michael , Franssen Nathan R. 
Published: November 2024

ABSTRACTEnvironmental temperature shapes the ontogeny of ectotherms by influencing rates of growth and development which can be key determinants of survival. Whereas the escalating impacts of water management on freshwater ecosystems is well documented, the effects of cold‐water releases from dams—which can alter downstream temperatures—remains relatively underexplored but may present novel challenges to endemic ectotherms. Specifically, little is known about how thermal depressions reshape phenotypic and genetic patterns during larval metamorphosis for fishes that evolved in warmwater systems. We assessed the effects of thermal shifts on larval ontogeny of the endangered razorback sucker (Xyrauchen texanus), which evolved in the warm waters of the Colorado River Basin, USA. We hypothesised that development is more sensitive to cold‐water influences than growth and that temperature would influence patterns in gene expression related to development. Our results supported these hypotheses and showed that both wild and laboratory‐reared larvae in slightly cooler temperatures exhibited delayed development, but similar growth compared to larvae reared in warmer conditions. These findings suggest growth and development in early ectotherm life stages can be decoupled, which follows patterns more like the temperature‐size rule than allometric scaling of development by size. We also observed transcriptional differences related to genes associated with stress responses and development in our laboratory‐reared fish; here, gene expression of fish from the coldest conditions at the end of the experiment was more similar to fish reared in warmer temperatures at the midpoint. Our findings suggest that modest temperature reductions can delay ontogeny and alter the transcriptional landscape while not necessarily limiting growth. This finding highlights the need for conservation practitioners to consider cascading impacts that even small temperature reductions can cause in riverine ecosystems.
The MYC Gene RrbHLH105 Contributes to Salt Stress–Induced Geraniol in Rose by Regulating Trehalose‐6‐Phosphate Signalling
Authors: Bao Mingyue , Xu Yong , Wei Guo , Bai Mengjuan , Wang Jianwen , Feng Liguo 
Published: November 2024

ABSTRACTRose (Rosa rugosa) is an important perfume plant, but its cultivation is significantly constrained by salt stress. Terpenes represent the most abundant volatile aromatic compounds in roses, yet little is known about how terpene metabolism responds to salt stress. In this study, salt‐treated rose petals presented significant accumulation of monoterpenes, including geraniol, due to the disruption of jasmonic acid (JA) biosynthesis and signalling. Overexpression and silencing analyses revealed a MYC transcription factor involved in JA signalling (RrbHLH105) as a repressor of geraniol biosynthesis. RrbHLH105 was shown to activate the trehalose‐6‐phosphate synthase genes RrTPS5 and RrTPS8 by binding to the E‐box (5′‐CANNTG‐3′). The increased trehalose‐6‐phosphate content and decreased geraniol content in rose petals overexpressing TPS5 or RrTPS8, along with the high accumulation of geraniol in petals where both RrbHLH105 and TPSs were cosilenced, indicate that trehalose signalling plays a role in the negative regulation of geraniol accumulation via the RrbHLH105‐TPS module. In summary, the suppression of RrbHLH105 by salt stress leads to excessive geraniol accumulation through the inhibition of both RrbHLH105‐mediated JA signalling and RrTPS‐mediated trehalose signalling in rose petals. Additionally, this study highlights the emerging role of RrbHLH105 as a critical integrator of JA and trehalose signalling crosstalk.
Outcomes of Pediatric Hepatocellular Carcinoma: A Single‐Center Experience With Resection Versus Transplantation
Authors: Medio Paula , Matesanz Sofía , Margareto María , Ostos Paula , Palomo Claudia , Hernández Oliveros Francisco , Moreno Ane Andrés 
Published: November 2024

ABSTRACTBackgroundPediatric hepatocellular carcinoma (HCC) presents significant challenges due to its aggressive nature, with survival depending on complete resection. We aimed to assess outcomes between liver resection (LR) and liver transplantation (LT).MethodsA total of 25 patients were retrieved, four of whom were classified as palliative at diagnosis. A subanalysis comparing cirrhotic liver (n = 14) versus de novo (n = 11) HCC was performed to identify confounding variables. Further evaluation focused on the 21 children with histologically confirmed HCC who underwent LR (n = 7) versus LT (n = 14). Kaplan–Meier survival curves were constructed.ResultsThe mean age was 7.8 ± 6.1 years for patients with cirrhotic liver and 12.1 ± 3.5 years for de novo HCC. Our group observed overall total survival rates of 100%, 85%, and 77% at 12, 36, and 60 months, respectively. De novo tumors had a higher recurrence rate and a poorer prognosis (p = 0.039 and p = 0.045). The disease‐free survival at 60 months in our cohort was significantly lower among the LR group compared to the LT group (14% vs. 82%; p = 0.0081). Recurrence after initial management (n = 8) showed location differences between LR and LT. Preoperative alpha‐fetoprotein (AFP) was elevated in 71% of children, but did not correlate with recurrence or compromised survival. Elevated AFP 3 months post‐operation affected the course negatively (p = 0.044). Tumor number and diameter exhibited a trend towards poorer outcomes.ConclusionsThese findings emphasize the need for comprehensive pediatric surgical guidelines for HCC. We recommend LT over LR in pediatric cases. Extrahepatic disease post‐neoadjuvant chemotherapy remains the only absolute contraindication.
Living‐Donor Liver Transplantation in a Carbamoyl Phosphate Synthetase I Deficiency Recipient With Scoliosis: A Case Report
Authors: Ninomiya Aoi , Uchida Hajime , Sakamoto Seisuke , Kodama Tasuku , Komine Ryuji , Shimizu Seiichi , Yanagi Yusuke , Fukuda Akinari , Miyazaki Osamu , Nosaka Shunsuke , Kasahara Mureo 
Published: November 2024

ABSTRACTBackgroundNeuromuscular scoliosis is associated with cerebral palsy caused by metabolic diseases. Patients with scoliosis require meticulous consideration in abdominal surgery, as scoliosis can reduce the abdominal cavity volume, compress abdominal organs, and cause abdominal complications. Special attention should be paid to the graft position, especially in the setting of liver transplantation (LT). We herein describe a pediatric case of LT for carbamoyl phosphate synthetase I (CPS1) deficiency with severe scoliosis.Case PresentationA 13‐year‐old girl with CPS1 deficiency was transferred to our department as a candidate for liver transplantation. She underwent living donor liver transplantation with a left lobe from her mother. Following LT, portal vein (PV) complications occurred due to the kinking anastomosis, requiring several rounds of graft repositioning, PV reconstruction, thrombectomy, and finally stent placement due to severe scoliosis. Technical efforts were made to ensure PV blood flow with stent placement via the umbilical vein. Three months after LT, she was discharged from our hospital with sufficient PV flow.ConclusionsThis report suggests the need for a careful surgical approach in patients with skeletal abnormalities, such as the management of complications arising from anatomical abnormalities and selection of the appropriate graft size. Preoperative assessment and surgical planning of both donors and recipients according to patient characteristics should be carefully conducted.
Bifurcation Near a Transcritical Singularity in Planar Singularly Perturbed Systems
Authors: Shen Jianhe , Zhang Xiang , Zhu Kun 
Published: November 2024

ABSTRACTWe classify all bifurcation phenomena of the flow near a transcritical singularity in planar singularly perturbed differential systems that do not have a breaking parameter via qualitative analysis and blow‐up technique. Here, the directional blown up vector fields can have several singularities and no first integral that are different from those in the literatures. The obtained local bifurcations are also illustrated by numerical simulations through a modified Leslie–Gower model, whose global dynamics is thereby obtained.
Dentistry and Sturge–Weber syndrome: Case report and narrative review
Authors: Abed Hassan , Alqarni Ali , Abuljadayel Jameel , Alosaimi Abdulaziz , Muhaymidan Nawaf , Althobaiti Abdullah , Aladwani Fahad , Alshammari Abdullah 
Published: November 2024

AbstractSturge–Weber syndrome (SWS) or encephalotrigeminal angiomatosis is a rare congenital disorder that affects the skin, brain, and eye. It is characterized by facial port‐wine stains, leptomeningeal angiomas, and glaucoma. SWS can also cause neurological complications, such as seizures, headaches, cognitive impairment, and stroke. Antiepileptic drugs that are used to treat seizures associated with SWS lead to the development of gingival hyperplasia which requires non‐surgical and/or surgical dental treatment. The purpose of this case report and narrative review is to provide an overview of the etiology, pathophysiology, clinical features, diagnosis, and treatment of SWS. This paper will also discuss the oral manifestations and dental considerations of SWS.
Trump, China, and the Republicans
Authors: Li Ben G. , Lu Yi , Sgro Pasquale , Xu Xing 
Published: November 2024

AbstractThe Republican Party has been the party most supportive of free trade in US politics for half a century. Donald Trump, the 45th US president, held a different stance from his party on free trade. We assess how Trump's China tariffs in mid‐2018 affected the performance of his party in its midterm House elections later that year. We construct a measure of each county's exposure to Trump's China tariffs and merge that with the Republican share of votes in the county. We find that the counties heavily exposed to the tariffs were more supportive of their Republican House candidates.