bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between Framingham risk score and degree of asymptomatic intracranial artery stenosis on stroke prone person
Authors: Junaidi Achmad , Marisdina Selly , Masita  , Indrajaya Taufik , Bahar Erial 
Published: July 2019

Abstract
Intracranial artery stenosis is the most frequent cause of ischemic stroke. Yet there is no recommendation for population-based screening with the goal of primary stroke prevention strategies. Framingham risk score D’Agostino’s modification has been shown as highly accurate screening to assess the risk of intracranial artery stenosis that lead to stroke. The aims of study to determine the correlation between Framingham risk score and degree of asymptomatic intracranial artery stenosis among stroke prone person. In the study, 32 patients were included. Intracranial stenosis was assessed by transcranial Doppler (TCD). Stenosis defined if the mean flow velocity (MFV) value was abnormal. Artery stenosis was most common in the left middle cerebral artery (MCA) (34.4%). After multiple linear regression analysis was done, only MFV of right carotid siphon artery (CSA) (p = 0.060; r = - 0.493), MFV of left anterior cerebral artery (ACA) (p = 0.073; r = 0.332), MFV of left MCA (p = 0.065; r = 0.341), had significant correlation. The conclusion appears that the stroke risk score has moderate correlation with the degree of asymptomatic intracranial artery stenosis, especially with MFV of right CSA, left ACA and left MCA.
Correlation of serum lipid profile with leptin levels of skin tags patients
Authors: Kurniawati Yuli , Devi Mutia , Yakub Kemas , Affandi Khairani , Marlina Allin 
Published: July 2019

Abstract
Skin tags may be associated with increased adipose deposition. Mechanism of skin tags formation is through the activation of leptin receptor in the dermis and epidermis. Recent study suggested that the presence of skin tags is associated with obesity, abnormal lipid profile and elevated serum leptin levels. Researcher are interested to analyse the correlation betwen serum lipid profile and leptin levels of patients with skin tags. This is a cross sectional study, conducted from October 2017 to February 2018 at Tumor and Dermatosurgery Divison-Dermatology and Venereology Department outpatient clinic in Dr. Mohammad Hoesin General Hospital Palembang. Sample study was obtained with consecutive sampling. There were 40 patients with skin tags that met the inclusion criteria included in the study. Serum lipid profile and serum leptin were measured. Statistic significant correlation between triglycerides and leptin levels was found (p=0.04; r=0.327), however there was no significant correlation between total cholesterol, LDL, HDL cholesterol with leptin levels (p=0.273; r=0.177, p=0.288; r=0.172, p=0.794; r=0.043). Triglyceride levels was found to have significant correlation with leptin levels.
Multidrug-resistant organisms (MDRO) patterns of GICU patients in Dr Mohammad Hoesin Hospital Palembang
Authors: Liana Phey , Patricia Venny , Agatha Cornellia 
Published: July 2019

Abstract

Multidrug-Resistant Organisms (MDRO) are organisms (bacteria) that are resistant to at least one antimicrobial of ≥3 antimicrobial classes. MDRO transmission most recorded in General intensive care unit (|GICU), which is also the high risk units of nosocomial infection. A total of 549 from 611 samples (89.8%) was identified as MDRO in 2015 and as many as 490 of the 552 samples (88.7%) in 2016. The most gram-negative bacteria in 2015 and 2016 were Acinetobacter baumannii (33% vs 30.4%), followed by Pseudomonas aeruginosa (24% vs 29.3%) and Klebsiella pneumoniae (11% vs 13.2%). In 2015, gram-positive bacteria had the highest level of resistance to antibiotics norfloxacin and ceftazidime, while in 2016 gram-positive bacteria had the high levels of resistance to antibiotics cotrimoxazole and ceftazidime. Gram-negative bacteria in 2015 had resistance to the antibiotic ampicillin, cefazolin, and tigecycline, whereas, in 2016, Gram-negative bacteria had resistance to the antibiotic imipenem, cefazolin, and tigecycline. The incidence of MDRO in 2016 decreased compared to 2015. In 2015 and 2016, a bacterial infection of GICU patient more often caused by gram-negative bacteria.
A successfull treatment of a rare case of dermatitis herpetiformis
Authors: Nopriyati  , Diba Sarah , Kartika Ika , Salfitri Noviana 
Published: July 2019

Abstract
Dermatitis herpetiformis (DH) is a rare autoimmune bullous disease characterized by intensely pruritic, chronic, and recurrent vesicles on extensor surfaces such as the elbows, knees, and buttocks. There is a genotype relationship with HLA-DR3, HLA DQw2, discovered about 80-90% of cases. Immunoflorescence is the gold standard for diagnosis, but serologic testing can help if immunofluorescence result is negative. On histopathological examination, at the tips of papillary dermis, a collection of neutrophils are found and granular immunoglobulins A. Dermatitis herpetiformis associated with gluten intolerance (celiac disease), although the mechanism is not fully understood. Patients with gluten free diet will reduce of this disease both in the skin and intestinal tract, thereby reducing risk of lymphoma progression. Dapsone is the main therapy, but it require monitoring side effects.
Effect of vitamin D3 supplementation towards vitamin D serum levels and Myasthenia Gravis Composite Score (MGCS)
Authors: Okparasta Andika , Iman Indrasyah Muhammad , Haddani Hasnawi , Bahar Erial 
Published: July 2019

Abstract
Myasthenia gravis (MG) is due to the functional impairment Treg cell that is as important as controlling the activation of T cells and inhibit the autoimmune response. Vitamin D3 is known to have an effect on increasing the quantity of Treg cells in the peripheral blood circulation and also functional so that it can suppress T cell activation. This study used a double-blind randomized controlled trial of 20 patients MG during the period from April to July 2017. The bivariate analysis using independent t-test and paired T-test. Multivariate analysis using linear regression. The mean change MGCS after vitamin D3 treatment group and placebo were not statistically significant (p = 0531). On the addition of vitamin D3 MGCS 1:19 ± 0.1 (p = 0798). There is a significant change (p = 0.041) in the mean levels of vitamin D after treatment between vitamin D3 and placebo groups. A significant increase (p = 0.005) vitamin D levels after administration of vitamin D3 in the amount of 17.88 ± 29.5 Ng/ml. Multivariate analysis showed that the initial MGCS and IMT values that most influence on the final MGCS value, and levels of vitamin D beginning the most influence on the final vitamin D levels. Vitamin D3 is 800 IU / day had no effect on the value of MGCS but the effect on changes in levels of vitamin D in the blood.
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis
Authors: Umi Partan Radiyati , Hidayat Rachmat 
Published: July 2019

Abstract
Tumour necrosis factor alpha (TNF-α) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-α gene at position 308 have been identified. We investigated whether these polymorphisms and circulating TNF-a levels were related to BMD in osteoporosis caused by COPD. We conducted this study to analyse the relationship between genetic polymorphism of tumour necrosis factor (TNF)-a -308 G/A and levels of pro-inflammatory cytokines, bone turnover marker levels, and the incidence of osteoporosis in COPD patients. This study was conducted on 70 COPD patients. BMD and bone area of the femoral neck and lumbar spines were measured using dual energy X-ray absorptiometry (Stratos ®). Blood cytokines (TNF-a, interleukin (IL)-6, IL-17, IL-1b) and Ctelopeptide (CTX), receptor activator of nuclear factor kB (RANKL), and osteoprotegerin (OPG) were analysed using ELISA. Polymorphism of the TNF-α gene -308 G/A was assayed by PCR-RFLP. The levels of cytokines were significantly increased in the osteoporosis group compared to those without. Polymorphism was significantly different between COPD with osteoporosis and COPD without. The frequency of the GA and AA genotypes was significantly increased in patients with osteoporosis. To conclude, there is a relationship between the TNF-a -308 G/A polymorphism and high levels of TNF-a, IL-1β, IL-6, IL-17, CTX, and the incidence of osteoporosis in patients with COPD.
Comparison between clot waveform analysis (CWA) of normal and abnormal aPTT of sepsis patients in Dr. Hasan Sadikin Hospital Bandung
Authors: Rahmawati Eny , Zamalek Dalimoenthe Nadjwa , Prihatni Delita 
Published: July 2019

Abstract
Sepsis is a clinical syndrome caused by the entry of harmful pathogens toxins into the blood vessels, which will cause the immune system response and ultimately will also interfere with hemostasis system including coagulation system which can end up with DIC. Therefore, monitoring of coagulation in sepsis becomes very important. The examination of coagulation such as PT and aPTT by mechanical methods only provide information about the timing of the coagulation and completely unknown how the coagulation process occurs. The Currently available coagulometer tool that checks the coagulation system with photo optical method to visualize the waveforms clot (Clot Waveform Analysis). This study was to determine the difference between CWA of normal and abnormal aPTT in sepsis patients. It was conducted at the Laboratory of Clinical Pathology, RSUP Dr. Hasan Sadikin Bandung. The subjects were all patients diagnosed with sepsis based on SOFA sepsis criteria, in the period of May 1, 2016, until August 31, 2016, were examined aPTT by CS2100i. The CWA were obtained from the examination of aPTT with the tool. Waveform of aPTT in sepsis was a biphasic waveform if the value of slope_ 1> -0.25% T / sec. The waveform were found in normal aPTT (83.33%) and prolonged aPTT group (100%). It were occured in the most normal aPTT groups and in all subjects with prolonged aPTT.This finding was useful for the treatment of sepsis patients when aPTT is normal because it proved that in sepsis patients with normal aPTT shows a biphasic waveform.
Biocoagulant of blood based on chitosan nanoparticle from crustacea
Authors: Sari Eka , Herawati  , Anshori Ulil , Nurmayulis  
Published: July 2019

Abstract
Chitosan is a chitin derivative natural polymer compound isolated from aquaculture waste, such as a crab shell that is the most chitosan source. Nanocitosan as a drug delivery offers delivery with non-harmful routes such as oral, nose, eye, and absorption. Nanokitosan can be absorbed by human organs that have nano-sized membrane penetration capabilities such as the kidneys, liver, and lungs where nanoparticles are 1-1,000 nm in size. Chitosan nanoparticles are prepared by ionic gelation techniques. The mechanism of this method is the formation of chitosan nanoparticles based on the electrostatic interaction between the positive amine groups on chitosan (-NH2) with the negative charge group of polyanion tripolyphospate (TPP). The first step is the preparation of chitosan, crab shell waste which is smoothed to 60 mesh, after subsequent smrubination to be smoothed to remove the protein content by dissolved in 3 N NaOH, then crude chitin demineralized to eliminate the mineral content contained in the crab shell with the addition of HCl 1 N and the presence of heating and stirring. The chitin obtained then enters the deacetylation stage to remove the acetyl group present in the crab shell by adding 50% NaOH and carried out by heating and stirring. The chitosan obtained was then dissolved in 3% lactic acid to obtain liquid chitosan, then added NaTPP to reduce the chitosan particle size to nano size. The obtained nitrocitosan size is 688 nm distribution with variation of NaTPP addition of 0.1% concentration and stirring 60 minutes. The resulting nitocytosan is tested to increase the rate of blood clotting that has been shown to shorten blood clotting time by up to 30 seconds.
The effect of pindang patin intake on serum cholesterol and LDL levels of male mice (Mus Musculus L.)
Authors: Sinulingga Sadakata , Okba Vekos Putri Humairoh , Haryadi Kusumo , Subandrate  
Published: July 2019

Abstract
High blood cholesterol level can cause atherosclerosis which is potentially cause coronary heart disease. Pindang patin is one of the favourite foods in Palembang which contain omega 3 fatty acids that can decrease blood cholesterol level. The aim of this study was to see the effect of pindang patin intake on total cholesterol and LDL. The type of this study was laboratory experimental using a pre-post-test randomized design with a control group in male mice (Mus musculus L.). The mice were given the high-fat diet by using egg yolk as much as 20% of body weight. The samples were divided into 5 groups: Negative Control, Positive Control, Dose I (0.26 ml/20 grams of body weight), Dose II (0.52 ml/20 grams of body weight) and Dose III (1.04 ml/20 grams of body weight). Blood samples were examined by using a spectrophotometer. Dose II and Dose III give the effect in decreasing the blood level of cholesterol in male mice, and Dose III give the effect in decreasing the blood level of LDL of male mice. Pindang patin can decrease the blood total cholesterol and LDL levels of male mice, and the best dose is in 1.04 ml/20 grams of body weight.
Comparison of videomicroscope and dermoscopy examination in detecting Sarcoptes scabiei
Authors: Farida Yahya Yulia , Astri Aryani Inda , Juhendy Merlina , Marina Octyvani Tiar 
Published: July 2019

Abstract
A non-invasive method of examination, dermoscopy (DS) can be used to detect Sarcoptes scabiei, but needs special training and expensive. Videomicroscope (VM) is able to visualize burrow, mites and eggs, so prompt treatment can be given. The aim of the study is to compare VM and DS, confirmed by skin scraping microscopic examination as standard diagnostic. The method was analytic observational study comparing VM and DS in 210 presumptive scabies patients in Palembang municipal orphanage. By consecutive sampling, 139 patients were included, 73 (52.5%) were men, 66 (47.5%) were women. Majority age were 11-20 years: 85 (61.2%) and 5-11 years: 44 (31.7%). The most common locations were interdigital manus/pedis 125 (89.9%), dorsum manus/pedis 106 (76.6%), wrist joint 102 (73.4%). VM’s sensitivity 92%, specificity 88%, accuracy 91%, positive predictive value (PPV) 96%, negative predictive value (NPV) 79%, area under curve (AUC) 90.3%. DS’ sensitivity 85%, specificity 71%, accuracy 81%, PPV 90%, NPV 60%, AUC 77.7%. There is a significant difference in specificity, accuracy and AUC, specificity of VM 88% and DS 71%, p 0.0007 < 0.05, accuracy value of VM 91%, DS 81%, with p 0.0257 < p 0.05; AUC of VM examination 90.3%, DS 77.7%, p 0.0069 < p 0.05. There was a significant difference between VM and DS examination with Z=2.23 p 0.0257 (Z>1.96). VM is better than DS, VM can be used as a diagnostic method especially at primary health service, a rapid mass screening and for evaluation of post-therapeutic follow up of scabies in epidemic area.
Optimization of The FDM Parameters to Improve The Compressive Strength of The PLA-copper Based Products
Authors: Huu N H , Phuoc D P , Huu T N , Thu H T T 
Published: July 2019

Abstract
Nowadays, Fused Deposition Modeling (FDM) has accomplished huge proficiency in modelling and wide variety in products shape and size in the industry. Alongside with its development, many problems came up, one of which is to ensure the technical requirements of the parts such as: compressive strength, tensile strength, dimensional accuracy, etc. To solve this problem, new composite materials has been developing and at the same time correlative process parameters has been optimized to achieve the most optimal technical requirements of that material. In this paper, we focus on researching the effect of process parameters consist of: raster angle; build direction and layer thickness on the part’s compressive strength made by one of the newest composite material which is the PLA-Copper filament. Central composite design (CCD) methodology is used to lower the experimental runs, the analysis of variance (ANOVA) method is employed to investigate the process parameters in order to achieve optimal compressive strength.
Effects of Multi-stack Ball Grid Array on Multi-stack Printed Circuit Board
Authors: Mukhtar M A F M , Abas A , W S Bahri W M E I 
Published: July 2019

Abstract
In the customary underfill (CUF) epitome process, there are couple of downsides experienced for instance, extended filling time, divided filling and voids improvement. Test and FVM reenactments have been directed to examine CUF dispensing systems for different types of ball grid array (BGA) tendencies out of a solitary layered PCB. In this task, the principle point is to enhance the stream of under filling mold crosswise over multi-stacks BGA. Package on Package (PoP), a strategy for coordinated circuit bundling, is utilized to consolidate BGA bundles vertically to permit higher segment thickness in devices. The L-type liquid stream in multi-stack BGA with edge introduction is contemplated and parameters of CUP exemplification, for example, void development and filling time were examined. The results demonstrated that the BGA sizes with the little weld balls put at the base layer, trailed by the medium size bind balls in the center stack and the biggest patch balls at the top layer has appeared to enhance the stream rate of the encapsulant ideally. Other arrangement in which the medium size solders placed are at the base layer, small solders at the center layer and largest solders on top of it, requires longest total filling time. The result also shows that the racing effect is present at central region and at the side of the layer. Because of the perimeter orientation design, the void formation is minimal and the race effect is not affecting much according experimental and computational result. This investigation additionally uncovers the capability of air gaps in improving velocity and pressure distribution near inlet and outlet to achieve faster total filling time at all layers of the BGA.
Optimisation of Flame Holder Design for Micro Gas Turbine
Authors: Enagi I I , Al-attab K A , Zainal Z A 
Published: July 2019

Abstract
Micro gas turbine (MGT) is an efficient alternative to costly generation and transmission of electricity especially in combined heat and power (CHP) for remote areas applications. In this study, an optimum geometry of a flame holder of MGT combustion chamber was determined in terms of height and diameter using solid works and ANSYS fluent. To determine and optimise the flame holder geometry, species transport and non-premix with radiation models were used in ANSYS fluent. Optimisation process was performed to select the best geometry of flame holder that produces lowest CO emission. The flame holder was divided in to three zones namely; pre-mix, combustion and dilution zones respectively. The test parameters applied during simulation include: the diameter of holes, number of rows per zone, heat flux through convective heat transfer, percentage excess air and location of dead zone. Optimum diameter of holes for the zones was found out to be 6, 8 and 10 mm with each having four rows of holes. In addition, 60 cm height and 2 inches diameter of flame holder showed a well distributed flame contours. The application of heat flux under radiation model reveals an acceptable CO emission of 102 ppm and average temperature of 1218 °C for the diesel fuel used.
Fuzzy Control of a Low Cost Mobile Robot Based on Vertical Lines in An Edge Detected Image
Authors: Seng N H , Samad Z , Nor N M 
Published: July 2019

Abstract
Edge detection is a computationally efficient and economical image processing technique as this method retains only the edges of surrounding objects for guiding the navigation and localization of a mobile robot. However, present edge detection based methods are heavily dependent on fusion with odometrical data which gradually accumulates localization errors. Moreover, they lack descriptive capabilities. In this paper, a fuzzy view descriptor which fused the information of the detected adjacent primary colours of the vertical lines in the mobile robot’s view with the fuzzified digital compass readings was used to ascertain the actual view. This fusion provided a sense of direction in addition to recognizing the frontal view. The fuzzified distance of the base pixel coordinates of the vertical line of interest determined the attraction of the mobile robot towards it or the repulsion from it. A fuzzy control rule base guided the mobile robot towards the vertical line of interest by constantly reducing its deviation in the edge image. The mobile robot managed to execute its consecutive movements in an intuitive manner without a precise mathematical model. The deviations of the vertical lines were kept small and the detection of the correct views was constantly reliable.
Production and Verification of RFID MM2 Microchip with Bump and On-Chip Antenna
Authors: Hassan A B , Ali I S A 
Published: July 2019

Abstract
This paper describes the special steps taken for the mass production of the Radio Frequency Identification (RFID) MM2 microchip. Since the MM2 is the unique semiconductor product with special on-chip antenna, it requires special production steps that might be quite different from ordinary electronics processes. In order to start the volume production, several preparation steps have to be taken in advance. These tasks are usually not included in the research and development stage. At the initial stage of the production, the production scheduling and quality management are the most important works. Since the availability of the production line varies by the demands, the production sometimes becomes very tight and it will cause the delivery shortage that is critical for customers. In this paper, the steps for the production preparation and production process are described. In order to confirm the proper operation against the process variation by lot, at least three lots (equivalent to 1 million microchips) of the wafers were produced. Very limited number of the microchips were used for the reliability test and the rest were used as the pre-production sample purposes. The uniqueness of the production steps compare to other chip production is the on-chip antenna (OCA) process i.e. build-up very small antenna coil with specified carrier frequency on top of the chips.
General Process Change Qualification framework for Wafer Fabrication
Authors: Nair D S , Chin J F 
Published: July 2019

Abstract
Wafer fabrication is the most value-added processes of semiconductor and electronics industries. The involved processes are state-of-the-art, most expensive, most complicated and highly sensitive. Any process changes require qualification dictated by different industry standards and also internal production performance specifications. The way a semiconductor industry performs qualification is often little known outside the industry and in contemporary literature. The paper offers insights into qualification process for wafer fabrication. Literature is reviewed on qualification in terms of reasons, stages and considerations. A general qualification framework currently employed in a foundry is shared as a valuable example.