bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin tissue dielectric constant in women with high body fat content
Authors: Mayrovitz Harvey N. , Forbes Jessica , Vemuri Adithi , Krolick Katelyn , Rubin Samantha 
Published: September 2019

AbstractBackgroundSkin tissue dielectric constant (TDC) measurements at a frequency of 300 MHz are used to assess skin properties in many conditions. Impacts of patient obesity on these values are unknown, and its quantitative assessment was the goal of this research.Materials and MethodsWomen in a weight loss program (N = 32) had TDC measured on forearm, biceps, neck, jowl, and submental regions along with measurements of total body fat (TBF), water (TBW), intracellular water (ICW), and extracellular water (ECW) via multi‐frequency bioimpedance. Group age (mean ± SD) was 40.0 ± 11.6 years (20‐70 years) with body mass index (BMI) of 31.8 ± 6.7 Kg/m2 (23.0‐49.9 Kg/m2). For analysis, subjects were divided into those with BMI < 30 Kg/m2 (subgroup A, n = 16) vs ≥30 Kg/m2 (subgroup B, n = 16).ResultsTissue dielectric constant at forearm and biceps decreased significantly (P < .001) with increasing depth from 0.5 to 1.5 to 2.5 mm but TDC values and their inter‐side ratios did not differ between subgroups A and B at any measured site. Although correlations between TBW, ECW, and ICW were significant (P < .001), there was no dependence of TDC values on any of these parameters.ConclusionsPreviously unknown TDC values for obese persons are provided and based on subgroup analyses suggest that skin TDC values in overweight and obese persons are not confounded by variables such as TBW and TBF. Further, since inter‐side ratios and their SD’s yielded thresholds for forearm and biceps similar to those established for women with normal BMI, use of these clinical inter‐arm TDC ratios now is extended to include a wider BMI range.
Overview and considerations for the reporting of clinical pathology interpretations in nonclinical toxicology studies
Authors: Aulbach Adam , Vitsky Allison , Arndt Tara , Ramaiah Lila , Logan Michael , Siska William , Cregar Laura , Tripathi Niraj , Adedeji Adeyemi , Provencher Anne , Gupta Ara , Jordan Holly , Bounous Denise , Boone Laura 
Published: September 2019

AbstractClinical pathology reporting practices are diverse among individuals and organizations involved in nonclinical toxicology studies. Clear, informative, and consistent reporting of clinical pathology results increases their value and avoids misinterpretation, resulting in decreased drug development costs. In recent years, certain common practices in clinical pathology reporting have been embraced by industry leaders and more consistently utilized across the pharmaceutical industry. The purpose of this manuscript is to review current clinical pathology reporting practices and to provide nonbinding suggestions to improve consistency, quality, and value of clinical pathology reports generated in support of nonclinical toxicology studies.
Characterization of Additive Layer Manufacturing Swirl Burner Surface Roughness and Its Effects on Flame Stability Using High-Speed Diagnostics
Authors: Runyon Jon , Giles Anthony , Marsh Richard , Pugh Daniel , Goktepe Burak , Bowen Philip , Morris Steve 
Published: September 2019

Abstract
In this study, two Inconel 625 swirl nozzle inserts with identical bulk geometry were constructed via additive layer manufacturing (ALM) for use in a generic gas turbine swirl burner. Further postprocessing by grit blasting of one swirl nozzle insert results in a quantifiable change to the surface roughness characteristics when compared with the unprocessed ALM swirl nozzle insert or a third nozzle insert which has been manufactured using traditional machining methods. An evaluation of the influence of variable surface roughness effects from these swirl nozzle inserts is therefore performed under preheated isothermal and combustion conditions for premixed methane-air flames at thermal power of 25 kW. High-speed velocimetry at the swirler exit under isothermal conditions gives evidence of the change in near-wall boundary layer thickness and turbulent fluctuations resulting from the change in nozzle surface roughness. Under atmospheric combustion conditions, this influence is further quantified using a combination of dynamic pressure, high-speed OH* chemiluminescence, and exhaust gas emissions measurements to evaluate the flame stabilization mechanisms at the lean blowoff and rich stability limits. Notable differences in flame stabilization are evident as the surface roughness is varied, and changes in rich stability limit were investigated in relation to changes in the near-wall turbulence intensity. Results show that precise control of in-process or postprocess surface roughness of wetted surfaces can positively influence burner stability limits and NOx emissions and must, therefore, be carefully considered in the ALM burner design process as well as computational fluid dynamics (CFD) models.
Power Improvement and NOx Reduction Strategies for a Hydrogen-Fueled Multicylinder Internal Combustion Engine
Authors: Krishnanunni Jayakrishnan , Bhatia Divesh , Dutta Viresh , Das Lalit Mohan 
Published: September 2019

Abstract
The conventional operation of a hydrogen internal combustion engine (ICE) under lean conditions results in low NOx emissions, however, at the cost of power generated. In this study, the power output of a hydrogen-fueled ICE was increased while maintaining the NOx emissions at low levels. The power output was increased by turbocharging, relatively richer operation, and spark timing optimization, whereas a combination of exhaust gas recirculation (EGR) and H2-selective catalytic reduction (H2-SCR) aftertreatment was used to reduce NOx emissions. Turbocharging resulted in a maximum torque output of 168 N·m at 3200 rpm as compared to 70 N·m at 1600 rpm for the naturally aspirated operation. However, the turbocharger could not generate enough boost at low speeds and the equivalence ratio was increased to obtain a high power output which resulted in a substantial increase in the NOx emissions. The use of EGR resulted in an average reduction of 72% in the NOx emissions. Retarding of spark timing significantly reduced the NOx emissions too, but was limited by the adverse impact on the torque. Since hydrogen would be available onboard a hydrogen-fueled vehicle, we for the first time report external injection of H2 for use as a reductant in the selective catalytic reduction unit. Even under extremely oxidizing conditions, the efficiency of aftertreatment was found to be 35.4% averaged over various speeds. A maximum of 83.7% overall reduction in NOx emissions was achieved by using the combined EGR and H2-SCR strategies.
Air-Assisted Atomization at Constant Mass and Momentum Flow Rate: Investigation into the Ambient Pressure Influence With the Smoothed Particle Hydrodynamics Method
Authors: Chaussonnet Geoffroy , Joshi Shreyas , Wachter Simon , Koch Rainer , Jakobs Tobias , Kolb Thomas , Bauer Hans-Jörg 
Published: September 2019

Abstract
A twin-fluid atomizer configuration is simulated by means of the two-dimensional (2D) weakly compressible smoothed particle hydrodynamics (SPH) method and compared to experiments. The gas-to-liquid ratio (GLR), the momentum flux ratio, and the velocity ratio are set constant for different ambient pressures, which lead to different gaseous flow sections. The objectives of this study are (i) to investigate the effect of ambient pressure at constant global parameters and (ii) to verify the capability of 2D SPH to qualitatively predict the proper disintegration mechanism and to recover the correct evolution of the spray characteristics. The setup consists of an axial liquid jet of water fragmented by a coflowing high-speed air stream (Ug = 80 m/s) in a pressurized atmosphere up to 16 bar. The results are compared to the experiment and presented in terms of (i) mean velocity profiles, (ii) drop size distributions, and (iii) Sauter mean diameter (SMD) of the spray. It is found that there exists an optimal pressure to minimize the mean size of the spray droplets. Finally, two new quantities related to atomization are presented: (i) the breakup activity that quantifies the number of breakup events per time and volume unit and (ii) the fragmentation spectrum of the whole breakup chain, which characterize the cascade phenomenon in terms of probability. The breakup activity confirms the presence of the optimal pressure, and the fragmentation spectrum gives information on the type of breakup, depending on the ambient pressure.
Enhancing the Performance of Solar Photovoltaic Water Pumping System by Water Cooling Over and Below the Photovoltaic Array
Authors: Tiwari Arunendra K. , Sontake Vimal C. , Kalamkar Vilas R. 
Published: September 2019

Abstract
Lower operating temperatures of the photovoltaic (PV) cells increase the performance and efficiency of any PV installation. The efficiency of solar photovoltaic water pumping system (SPVWPS) decreases considerably with the increase in the PV cell temperature. In this paper, the performance of a 2 hp SPVWPS has been investigated experimentally, for the influence of panel cooling, using water. The experimental observations have been made under climatic conditions of Visvesvaraya National Institute of Technology, Nagpur campus, India, during the year 2018. The performance was evaluated under four different cases: (a) without panel cooling, (b) with water cooling on the top of the panel surface, (c) with water cooling on beneath the surface of the panel, and (d) with water cooling beneath the surface of the panel using jute. The effect of different cooling cases on the various performance parameters such as discharge, power output, pump efficiency, and system efficiency has been analyzed and discussed. The results showed that the water cooling on the top of the panel and beneath the surface of the panel with jute has considerable influence on performance enhancement when compared with other cases.
Nonlinear Evolution of a Steep, Focusing Wave Group in Deep Water Simulated With oceanwave3d
Authors: Barratt Dylan , Bingham Harry B. , Adcock Thomas A. A. 
Published: September 2019

Abstract
Steep, focusing waves can experience fast and local nonlinear evolution of the spectrum due to wave–wave interactions resulting in energy transfer to both higher and lower wavenumber components. The shape and kinematics of a steep wave may, thus, differ substantially from the predictions of linear theory. We have investigated the role of nonlinear interactions on group shape for a steep, narrow-banded, directionally spread wave group focusing in deep water using the fully nonlinear potential flow solver, oceanwave3d. Exact second-order correction of the initial conditions has been implemented together with a novel third-order approximate correction based on a Stokes-type formulation for surface elevation combined with a scaling argument for the third-order velocity potential. Four-phase separation reveals that the third-order scheme provides a good estimate for the third-order superharmonics. A quantitative assessment of numerical error has also been performed for the spatial and temporal discretization, including energy conservation, a reversibility check, and validation against previous simulations performed with a higher-order spectral (HOS) code. The initially narrow-banded amplitude spectrum exhibits the formation of “sidelobes” at angles of approximately ±35deg to the spectral peak during the simulated extreme wave event, occurring in approximately ten wave periods, with a preferential energy transfer to high-wavenumber components. The directional energy transfer is attributed to resonant third-order interactions with a discussion of the engineering implications.
Effects of Surface Roughness Parameters on Tribological Performance for Micro-textured Eutectic Aluminum–Silicon Alloy
Authors: Chen Luanxia , Liu Zhanqiang , Wang Xin , Wang Qingqing , Liang Xiaoliang 
Published: September 2019

Abstract
Micro-textured samples with different depths exhibit various contact surface morphology parameters including Sa, Sq, Ssk, and Sku, and material ratio curves. In this paper, the relationship between micro-textures and roughness parameters was investigated. The effect mechanism of micro-textures on the friction and wear through the height and functional roughness parameters was elucidated. Micro-textured samples presented more negative Ssk, higher Sku, and larger Svk with the increasing dimple depth. The pin-on-disc reciprocating tribological test results indicated that the more negative Ssk, higher Sku, and larger Svk presented lower friction coefficient under the constant Sa and Sq. The wear topographies for the flat and micro-textured specimens with various dimple depths were examined by laser scanning confocal microscope. X-ray photoelectron spectroscopy was employed to describe the formation of absorbed film and tribofilm on the worn surface of flat and micro-textured samples. It was confirmed that more negative Ssk, higher Sku, and material ratio curves with their relative parameters (smaller value of Spk, Sk, Smr1, and larger value of Svk) could be used for predicting the tribological performance of micro-textured samples.
Identifying and measuring the severity of somatic symptom disorder using the Self-reported Somatic Symptom Scale-China (SSS-CN): a research protocol for a diagnostic study
Authors: Jiang Meng , Zhang Weituo , Su Xuan , Gao Chuang , Chen Bingxu , Feng Zehao , Mao Jialiang , Pu Jun 
Published: September 2019

IntroductionThe detection rate of somatic symptom disorder (SSD) in general hospitals is unsatisfactory. Self-report questionnaires that assess both somatic symptoms and psychological characteristics will improve the process of screening for SSD. The Somatic Symptom Scale-China (SSS-CN) questionnaire has been developed to meet this urgent clinical demand. The aim of this research is to validate the self-reported SSS-CN as a timely and practical instrument that can be used to identify SSD and to assess the severity of this disorder.Methods and analysisAt least 852 patients without organic disease but presenting physical discomfort will be recruited at a general hospital. Each patient will undergo aDiagnostic and Statistical Manual of Mental Disorders, 5th Edition(DSM-5)-guided physician diagnosis, including disease identification and severity assessment, as the reference standard. This research will compare the diagnostic performance of the SSS-CN for SSD, the Patient Health Questionnaire-15 (PHQ-15) and other SSD-related questionnaires. Statistical tests to measure the area under the curve (AUC) and volume under the surface of the receiver operating curve will be used to assess the accuracy of the SSD identification and the severity assessment, respectively. In addition to this standard diagnostic study, we will conduct follow-up investigations to explore the effectiveness of the SSS-CN in monitoring treatment effects.Ethics and disseminationEthical approval was obtained from the Renji Hospital Human Research Ethics Committee, approval number 2 015 016. The findings of this study will be disseminated via peer-reviewed journals and presented at international conferences.Trial registration numberNCT03513185.
Effectiveness of combined eccentric and concentric exercise over traditional cardiac exercise rehabilitation programme in patients with chronic heart failure: protocol for a randomised controlled study
Authors: Plaquevent-Hostache Guillaume , Touron Julianne , Costes Frédéric , Perrault Hélène , Clerfond Guillaume , Cuenin Christine , Moisa Andreea , Pereira Bruno , Boiteux Marie-Claire , Eschalier Romain , Richard Ruddy 
Published: September 2019

IntroductionExercise-based rehabilitation is a standard feature of chronic heart failure management. The effectiveness of eccentric exercise could offer new opportunities for better tailoring rehabilitation programme to patients’ limitations. The goal of the study is to contrast the impact of a mixed eccentric and concentric cycling training programme, to that of conventional concentric cycling rehabilitation in patients with chronic heart failure (peak oxygen consumption (VO2Peak) < 15 mL⋅kg-1⋅min-1, ejection fraction <40%).Methods and analysisIt is a prospective, open, controlled and randomised study (2×25 subjects) carried out in a single centre. Subjects will perform five exercise sessions per week per the randomisation outcome, with the intervention group performing eccentric in three of the five weekly sessions while the control group will perform the five sessions of concentric exercise. Cycling intensity will be the same in both groups and fixed to the power associated with the first ventilatory threshold. Self-management education programme, callisthenics sessions and muscle strength trainings will also be carried out as for any heart failure patient normally included in the rehabilitation programme. The primary outcome will be the change in distance covered during the 6 min walk test. Secondary outcomes will include other physical mobility parameters, functional exercise capacities, quality of life and body composition as well as skeletal muscle properties including mitochondrial function parameters.Ethics and disseminationThe study has been approved by the institutional ethics review board (17.079) and the French regulatory authority for research (2017-A00969-44). Adverse events that could occur during the protocol will be reported to the principal investigator. The results will be published in an international peer-reviewed journal.Trial registration numberNCT03716778.
Emergent $$\alpha $$-like fermionic vacuum structure and entanglement in the hyperbolic de Sitter spacetime
Authors: Bhattacharya Sourav , Chakrabortty Shankhadeep , Goyal Shivang 
Published: September 2019

AbstractWe report a non-trivial feature of the vacuum structure of free massive or massless Dirac fields in the hyperbolic de Sitter spacetime. Here we have two causally disconnected regions, sayRandLseparated by another region,C. We are interested in the field theory in$$R\cup L$$R∪Lto understand the long range quantum correlations betweenRandL. There are local modes of the Dirac field having supports individually either inRorL, as well as global modes found via analytically continuing theRmodes toLand vice versa. However, we show that unlike the case of a scalar field, the analytic continuation does not preserve the orthogonality of the resulting global modes. Accordingly, we need to orthonormalise them following the Gram–Schmidt prescription, prior to the field quantisation in order to preserve the canonical anti-commutation relations. We observe that this prescription naturally incorporates a spacetime independent continuous parameter,$$\theta _{\mathrm{RL}}$$θRL, into the picture. Thus interestingly, we obtain a naturally emerging one-parameter family of$$\alpha $$α-like de Sitter vacua. The values of$$\theta _{\mathrm{RL}}$$θRLyielding the usual thermal spectra of massless created particles are pointed out. Next, using these vacua, we investigate both entanglement and Rényi entropies of either of the regions and demonstrate their dependence on$$\theta _{\mathrm{RL}}$$θRL.
Exercise training upregulates Nrf2 protein in the rostral ventrolateral medulla of mice with heart failure
Authors: Wafi Ahmed M. , Yu Li , Gao Lie , Zucker Irving H. 
Published: September 2019

Chronic heart failure (CHF) is associated with global oxidative stress, which contributes to sympathoexcitation. Increased reactive oxygen species in the brain accumulate within neurons and lead to enhanced neuronal excitability. Exercise training (ExT) is associated with a reduction of oxidative stress by upregulation of antioxidant enzymes. The link between ExT and antioxidant enzyme expression in the brain of animals with CHF is not clear. We hypothesized that ExT enhances transcription and translation of the nuclear factor erythroid 2-related factor 2 (Nrf2) gene, a master transcription factor that modulates antioxidant enzyme gene expression, in the rostral ventrolateral medulla (RVLM) of mice with CHF. Mice were divided into the following groups: Sham sedentary (Sham-Sed), Sham-ExT, CHF-Sed, and CHF-ExT. After 8 wk of ExT, we measured Nrf2 and NAD(P)H dehydrogenase [quinone] 1 (NQO-1) message and protein expression along with maximal exercise tolerance and urinary norepinephrine (NE) excretion. We found that Nrf2 and NQO-1 mRNA and protein expression in the RVLM were lower in CHF-Sed mice compared with Sham-Sed. ExT attenuated the CHF-induced reduction of Nrf2 and NQO-1 mRNA and protein expression in the RVLM. NE excretion was higher in CHF-Sed mice compared with Sham-Sed (666.8 ± 79.3 ng/24 h, n = 6 vs. 397.8 ± 43.7 ng/24 h, P = 0.04). CHF-ExT mice exhibited reduced urinary NE excretion compared with CHF-Sed (360.7 ± 41.7 ng, n = 4 vs. 666.8 ± 79.3 ng, n = 6; P = 0.03). We conclude that ExT-induced upregulation of Nrf2 in the RVLM contributes to the beneficial effects of ExT on sympathetic function in the heart failure state. NEW & NOTEWORTHY This study provide evidence for an important role for exercise training in the modulation of antioxidant enzyme production in the rostral ventrolateral medulla (RVLM) in the heart failure state. We show here a correlation between exercise training and the expression of the antioxidant transcription factor Nrf2 in the RVLM. Exercise training reduced sympathetic function (norepinephrine excretion) and upregulated both Nrf2 and the antioxidant enzyme NQO-1. We conclude that Nrf2 in the RVLM may be an important target for controlling sympathetic outflow in heart failure.
A ceRNA Circuitry Involving the Long Noncoding RNA Klhl14-AS, Pax8, and Bcl2 Drives Thyroid Carcinogenesis
Authors: Credendino Sara C. , Bellone Maria L. , Lewin Nicole , Amendola Elena , Sanges Remo , Basu Swaraj , Sepe Romina , Decaussin-Petrucci Myriam , Tinto Nadia , Fusco Alfredo , De Felice Mario , De Vita Gabriella 
Published: September 2019

Abstract

Klhl14-AS is a long noncoding RNA expressed since early specification of thyroid bud and is the most enriched gene in the mouse thyroid primordium at E10.5. Here, we studied its involvement in thyroid carcinogenesis by analyzing its expression in cancer tissues and different models of neoplastic transformation. Compared with normal thyroid tissue and cells, Klhl14-AS was significantly downregulated in human thyroid carcinoma tissue specimens, particularly the anaplastic histotype, thyroid cancer cell lines, and rodent models of thyroid cancer. Downregulating the expression of Klhl14-AS in normal thyroid cells decreased the expression of thyroid differentiation markers and cell death and increased cell viability. These effects were mediated by the binding of Klhl14-AS to two miRNAs, Mir182-5p and Mir20a-5p, which silenced Pax8 and Bcl2, both essential players of thyroid differentiation. MIR182-5p and MIR20a-5p were upregulated in human thyroid cancer and thyroid cancer experimental models and their effects on Pax8 and Bcl2 were rescued by Klhl14-AS overexpression, confirming Klhl14-AS as a ceRNA for both Pax8 and Bcl2. This work connects deregulation of differentiation with increased proliferation and survival in thyroid neoplastic cells and highlights a novel ceRNA circuitry involving key regulators of thyroid physiology.

Significance:
This study describes a new ceRNA with potential tumor suppression activity and helps us better understand the regulatory mechanisms during thyroid differentiation and carcinogenesis.