bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique Role of Arginine in Positively‐Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities
Authors: Zhang Wei , Liu Jun , Yang Kun , Qu Wei , Liu Ke , Liu Na , Gu Bin , Hu Nan , Ji Junhui , Chu Paul K. , Wang Huaiyu 
Published: October 2019

AbstractOrthopedic implants made of titanium and titanium alloys are vulnerable to invasion of pathogenic bacteria and hence, it is desirable to endow implants with the antibacterial capability to mitigate postsurgical infection and other undesirable side‐effects. In this study, arginine is combined with polyhexamethylene biguaidine hydrochloride (PHMB) to fabricate an antibacterial coating on titanium samples. As arginine with the guanidinium form is similar to PHMB, the coating is positively‐charged and delivers excellent antibacterial performance due to the high surface potential. Furthermore, arginine is a natural α‐amino acid being friendlier to tissues than PHMB and the coating delivers good osteogenetic performance in vitro and in vivo in addition to a low level of inflammatory response. The combination of cationic arginine and PHMB enhances the antibacterial and osteogenetic functions simultaneously and suggests clinical potential.
Ethyl acetate as a bio‐based solvent to reduce energy intensity and CO2 emissions of in situ bitumen recovery
Authors: Zirahi Ali , Sadeghi Yamchi Hassan , Haddadnia Ali , Zirrahi Mohsen , Hassanzadeh Hassan , Abedi Jalal 
Published: October 2019

AbstractWe introduce ethyl acetate (EA), a bio‐based chemical, as a potential solvent for bitumen recovery through comprehensive phase behavior and numerical simulation studies. Phase behavior and thermophysical properties of EA/live bitumen are measured at temperatures and pressures up to 190°C and 4 MPa, respectively. Experimental studies suggested that coinjection of EA with steam can reduce the bitumen viscosity by several orders of magnitude. Our numerical simulations show that coinjection of 2–8 mol% EA with steam can significantly reduce the steam‐oil‐ratio (SOR) by almost 0.9 units while increasing the bitumen production rate. This reduction in SOR can be translated to significant energy saving of ~2.2 GJ, emission reduction of ~120 kg of CO2, and wastewater reduction of ~120 m3 per ton of the produced bitumen, which are almost 20–25% lower than the steam‐assisted gravity drainage (SAGD) process.
Enhanced modification technique for polyacrylonitrile UF membranes by direct hydrolysis in the immersion bath
Authors: Cheraghali Reihaneh , Maghsoud Zahra 
Published: October 2019

ABSTRACTConventional hydrolysis modification of polyacrylonitrile (PAN) membranes is usually carried out in a post‐treatment step during which hydrophilic groups are created on the membrane surface. In this article, however, direct hydrolysis in the immersion bath is proposed as a new and simple approach for simultaneous membrane preparation and modification. The main advantages of this method include lower alkali concentrations, promptness, and the lack of need for elevating temperature compared to other studies. The cast films were immersed in the coagulation bath containing aqueous NaOH solutions of various concentrations (0.003, 0.0125, 0.025, 0.05, and 0.1 M) for 1, 3, 5, and 10 min, which were then transferred to a bath of pure water. Membranes were characterized by pure water flux, porosity, average pore diameter, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle, mechanical properties, rejection, and flux recovery ratio (FRR) measurements. At all treatment times, the pure water flux of modified membranes reached its maximum at low NaOH concentrations with a substantial increase (210%) in the membrane treated with 0.0125 M NaOH for 1 min. Furthermore, the kinetics of the hydrolysis reaction was considered to provide deeper insights into morphological changes occurring during the hydrolysis. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48583.
Study on the performance of syntactic foam reinforced by hybrid functionalized carbon nanotubes
Authors: Ya Bin , Wang Yaosheng , Meng Linggang , Zhou Bingwen , Zhang Xingguo 
Published: October 2019

ABSTRACTHollow glass microspheres (HGMs)/epoxy syntactic foam were reinforced by hybrid functionalized carbon nanotubes that were synthesized by simultaneous covalent and noncovalent functionalization of carbon nanotubes. The effect of hybrid functionalized carbon nanotubes on density, mechanical properties, and water absorption of HGMs/epoxy syntactic foam was studied. The study indicated that the dispersion of carbon nanotubes in epoxy resin can be improved by hybrid functionalization. The compression strength of syntactic foam reinforced by hybrid functionalized carbon nanotubes was significantly enhanced. The maximum compressive strength of syntactic foam corresponding to chitosan modified carbon nanotubes approached 60 MPa. Hybrid functionalized carbon nanotubes had little effect on the water absorption ability of syntactic foam, and was less than 1%. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48586.
Tidal disruption events as a site of an evolving relativistic spectral line
Authors: Štolc Marcel , Karas Vladimír 
Published: October 2019

AbstractIn nuclei of galaxies, strong tidal forces can destroy stars passing within a critical distance from the central supermassive black hole (SMBH). Observational signatures of tidal disruption events (TDEs) depend on the environment around the SBMH horizon and the level of its accretion activity. Evidence for optical and ultraviolet spectral features has been reported in TDE flares; nevertheless, to test the effects of general relativity in the immediate vicinity of SMBH, the relativistically broadened and skewed X‐ray line would tell us significantly more useful information. This will require to proceed beyond inactive nuclei. To this end, we consider a system where the material from a disrupted star forms a gaseous ring that circularizes near the tidal radius around SMBH, it gradually spreads in radius by viscous processes and resides embedded within a hot corona. In our test calculation, the remnant trail is assumed to be fully circularized and embedded in a hot environment and illuminated by X‐rays from a surrounding corona or a jet base of (mild) active galactic nucleus activity. We show the expected effects on the observed profile and the centroid energy. In the future, the evolving spectral features can enhance the diagnostic capability and provide a novel way to reveal the parameters of TDEs in such sources; the distance of the remnant gas from the SMBH, the radial extent of the gaseous trail, and the spin of the SMBH could be measured.
Methods for identifying high‐redshift galaxy cluster candidates
Authors: Pinter Sandor , Balázs Lajos G. , Bagoly Zsolt , Horvath Istvan , Rácz István I. , Tóth Viktor L. 
Published: October 2019

AbstractRecent theories linked long gamma ray bursts (GRBs) to galaxies with rapid star formation or starburst; thus, we expect that long GRBs (LGRBs) are more frequent in midcluster galaxies where mergers and tidal interactions between gas‐rich galaxies are more likely to occur. Yet there is no galaxy cluster known to be associated with LGRBs. We demonstrate that, based on deep, single‐band Subaru Hyper Suprime‐Cam observations, we may provide constraints on photometric redshifts of groups of galaxies. We compare three methods: cosmological approach, pseudoinverse matrix, and random forests to estimate galaxy and quasar redshifts. Comparing our results to spectroscopic redshifts of Sloan Digital Sky Survey's‐detected extragalactic sources, random forests may provide the highest accuracy with as low as 17 percentage error. This is a powerful method to find clusters to place GRB host galaxies in their local environment.
The Tissue‐Supported Sling Suture: Technique and Clinical Applications
Authors: McGary Ryan T. , Johnson Thomas M. , Berridge Joshua P. , Wilson James P. , Baron Dmitry 
Published: October 2019

IntroductionContinuous and interrupted sling sutures (ISSs) are used around teeth in contemporary periodontics. However, conventional ISSs depend upon favorable tooth morphology for stability through the early healing period. The purpose of this report is to present a variation of the classic ISS that does not rely on favorable tooth morphology.Case SeriesTissue‐supported sling sutures (TSSs) were used for six patients undergoing root coverage, gingival augmentation, or pontic site development (guided bone regeneration) procedures.ConclusionsAlthough techniques such as vertical mattress suturing may support greater coronal flap advancement, the TSS technique does maintain coronal flap position while minimizing trauma to papillae. TSS stability is independent of tooth morphology and may offer clinicians flexibility in achieving reliable closure over hard and soft tissue implants. Like mattress sutures, TSSs reduce tension at the crestal incision line in tissue grafting procedures.
Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy
Authors: Dauner Martin , Skerra Arne 
Published: October 2019

AbstractIron acquisition mediated by siderophores, high‐affinity chelators for which bacteria have evolved specific synthesis and uptake mechanisms, plays a crucial role in microbiology and in host–pathogen interactions. In the ongoing fight against bacterial infections, this area has attracted biomedical interest. Beyond several approaches to interfere with siderophore‐mediated iron uptake from medicinal and immunochemistry, the development of high‐affinity protein scavengers that tightly complex the siderophores produced by pathogenic bacteria has appeared as a novel strategy. Such binding proteins have been engineered based on siderocalin—also known as lipocalin 2—an endogenous human scavenger of enterobactin and bacillibactin that controls the systemic spreading of commensal bacteria such as Escherichia coli. By using combinatorial protein design, siderocalin was reshaped to bind several siderophores from Pseudomonas aeruginosa and, in particular, petrobactin from Bacillus anthracis, none of which is recognized by the natural protein. Such engineered versions of siderocalin effectively suppress the growth of corresponding pathogenic bacteria by depriving them of their iron supply and offer the potential to complement antibiotic therapy in situations of acute or persistent infection.
Towards Stable and Conductive Titanium Oxynitride High‐Surface‐Area Support for Iridium Nanoparticles as Oxygen Evolution Reaction Electrocatalyst
Authors: Bele Marjan , Stojanovski Kevin , Jovanovič Primoz , Moriau Leonard , Koderman Podboršek Gorazd , Moškon Jože , Umek Polona , Sluban Melita , Dražič Goran , Hodnik Nejc , Gaberšček Miran 
Published: October 2019

AbstractThe front cover artwork for Issue 20/2019 is a collaboration between the National Institute of Chemistry (Slovenia) and the Jožef Stefan Institute (Slovenia). The image shows titanium oxynitride nanoribbons with finely dispersed iridium nanoparticles as an oxygen evolution reaction electrocatalyst. See the Full Paper itself at https://doi.org/10.1002/cctc.201901487.
PV‐betriebene Umkehrosmoseanlage zur Meerwasserentsalzung – Modellierung und Analyse verschiedener Energieversorgungsvarianten
Authors: Sanna Anas , Kaltschmitt Martin , Ernst Mathias 
Published: October 2019

AbstractDie Umkehrosmose ist eine sehr energieeffiziente Option zur Meerwasserentsalzung. Da sie nur elektrische Energie nachfragt, bietet sich aus Klimaschutzgründen eine Kombination von Umkehrosmose‐ und Photovoltaik(PV)‐Anlagen an. Deshalb wird hier eine PV‐basierte Umkehrosmose‐Anlage zur Meerwasserentsalzung für einen Standort in Saudi‐Arabien ausgelegt und modelliert. Ausgehend davon werden verschiedene Varianten einer PV‐versorgten Meerwasserentsalzungsanlage untersucht und daraus Schlussfolgerungen für den Bau derartiger Anlagen abgeleitet.
Entrapment, positive psychological functioning and suicide ideation: A moderation analysis
Authors: Teismann Tobias , Brailovskaia Julia 
Published: October 2019

AbstractThe Integrated Motivational–Volitional (IMV) Model of suicide posits that the association between perceptions of entrapment and suicide ideation is buffered by so‐called motivational moderators. The present study investigated, whether positive mental health as well as different facets of psychological well‐being qualify as motivational moderators. Possible moderator effects were investigated in an online sample (N = 301). Results demonstrated that positive mental health and psychological well‐being moderate the association between entrapment and suicide ideation. These findings underscore the importance of entrapment and positive psychological functioning in understanding pathways to suicide ideation.
Experimental research on leaf vein geometric characteristics of multibranch horizontal well for coalbed methane recovery
Authors: Guo Xiaoyang , Deng Cunbao , Fan Yongpeng , Mu Yongliang , Fan Nan 
Published: October 2019

AbstractThe similarity in the structure and function between leaf veins and multibranch wells provided the inspiration for a novel design of multibranch coalbed methane (CBM) well. The leaf vein structure of leaves was analyzed by leaf specimen scanning and microstructure measurements. Fluorescence labeling experiments were used to study the influence of leaf vein structure on moisture transport, and the geometric characteristics were obtained. A CBM extraction physical simulation experiment was carried out in a custom‐made experimental system. The temporal and spatial evolution of seepage‐temperature fields in reservoir during CBM recovery were studied, and the influence of leaf vein geometric characteristics and how they affected was analyzed. The results indicated that in experimental gas extraction, asymmetrically distributed branch wells improved the CBM recovery 4.02% higher than symmetric structure after 1000 seconds. The reduction in branch well angle leads to the decrease in gas pressure relief. If the branch well angle is reduced by 20°, it reduced by 11.34% after 4000 seconds. When the branch well length increased by 50%, it increased by 28.37%. Coalbed methane recovery effect can be improved by 6.81%, when the distance between branch wells increased by 50%. In the early extraction stage, the reduction in methane pressure and reservoir temperature was positively correlated with the initial methane pressure, but they were less affected in the later stage.
Effect-Directed Analysis of Progestogens and Glucocorticoids at Trace Concentrations in River Water
Authors: Hashmi Muhammad Arslan Kamal , Krauss Martin , Escher Beate I. , Teodorovic Ivana , Brack Werner 
Published: October 2019

Abstract
Effect-based monitoring is increasingly applied to detect and—in conjunction with chemical analysis—to identify endocrine-disrupting compounds (EDCs) in the environment. Although this approach of effect-directed analysis has been successfully demonstrated for estrogenicity and androgenicity, data on progestogens and glucocorticoids driving endocrine disruption are quite limited. We investigated progestogenic and glucocorticoid activities in Danube River water receiving untreated wastewater from Novi Sad, Serbia. After a 2-step fractionation, all fractions were tested with reporter gene bioassays for agonistic and antagonistic hormonal responses at progestogenic and glucocorticoid hormone receptors as well as with target and nontarget analytical screening of active fractions by liquid chromatography–high-resolution mass spectrometry. Due to masking by cytotoxic mixture components, the effects could not be detected in the raw water extract but were unraveled only after fractionation. Target chemical screening of the fraction that was active in the progesterone receptor (PR) assay revealed that progesterone and megestrol acetate were predominant drivers of PR-mediated activity along with medroxyprogesterone, dihydrotestosterone, androsterone, and epiandrosterone. Hydrocortisone was detected at sub-ng/L concentration in the active fraction in the glucocorticoid receptor (GR) assay but could not explain a significant fraction of the observed GR activity. The present study indicates that effect-based monitoring is a powerful tool to detect EDCs in the aquatic environment but that fractionation may be required to avoid masking effects of mixture components. Future effect-directed analysis studies are required to better understand the occurrence of EDCs and masking compounds in different lipophilicity windows, to finally reduce fractionation requirements for monitoring to a smart clean-up. Environ Toxicol Chem 2019;39:189–199. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
Abstract
Summary of the work flow of effect-directed analysis of wastewater-impacted Danube River water and the results specifying the main drivers of progestogenic effects.
Integrating thermal‐concentration smoothed profile with lattice Boltzmann methods for simulating sedimentation of nonisothermal circular particles
Authors: Safa Raziyeh , Soltani Goharrizi Ataallah , Jahanshahi Javaran Ebrahim , Jafari Saeed 
Published: October 2019

SummaryA thermal‐concentration smoothed profile‐lattice Boltzmann method is proposed to study the effect of the concentration field on the dynamic behavior of nonisothermal cylindrical particles during the sedimentation process. The velocity, temperature, and concentration equations are solved using the lattice Boltzmann method. Moreover, the smoothed profile method is employed to enforce the nonslip boundary condition as well as constant temperature and constant concentration boundary conditions at the particles surfaces. Moreover, the Boussinesq approximation is used to couple the velocities, temperatures, and concentrations fields. The proposed combined method is validated by comparing the present numerical results with those found in the literature, showing good consistency. Then, the effect of the concentration buoyancy on the behavior of nonisothermal particles is discussed. In addition, the effect of Prandtl, Schmidt, and thermal Grashof numbers on the settling process is investigated. The results show that, by adding the effect of concentration, the maximum settling velocity of hot particles is reduced more relative to the cold ones; accordingly, the cold particles are settled faster than the hot ones. Finally, the sedimentation of two particles in a container at high thermal Grashof is investigated. It is shown that, at high thermal Grashof, there is an intense competition between the buoyancy force and gravity for the hot particles. The buoyancy flow generated leads to the reversal of the drafting‐kissing‐tumbling motion of the hot particles, making the particles move upward.
Method of detection of thyroid nodules: correlation with frequency of fine‐needle aspiration and malignancy rate
Authors: Rothberger Gary D. , Cohen Melissa , Sahay Priya , Szczepanczyk Paula T. , Islam Shahidul 
Published: October 2019

AbstractBackgroundThyroid nodules are commonly found by screening, and the clinical implications are unclear.MethodsWe retrospectively studied 460 patients who were evaluated for thyroid nodules. Medical records were queried to determine how the nodules were detected. We compared the rates of fine needle aspiration (FNA) and malignancy between nodules detected clinically, incidentally on imaging, or by screening.ResultsNodules were detected clinically in 184 patients (40%), incidentally in 121 patients (26%), and by screening in 155 patients (34%). The rates of FNA and malignancy were lower for patients with nodules detected by screening (28% and 1%, respectively), compared to patients with clinically apparent nodules (75% and 15%) and patients with incidental nodules (69% and 8% [P < .001]).ConclusionThyroid nodules detected via screening has a lower rate of FNA and is less likely to be diagnosed as a malignancy compared to nodules detected clinically or incidentally on imaging. Thyroid ultrasound examinations should be reserved for nodules that are clinically apparent or to evaluate nodules found incidentally on imaging.
Overexpressed microRNA‐103a‐3p inhibits acute lower‐extremity deep venous thrombosis via inhibition of CXCL12
Authors: Sun Shaoliang , Chai Shanyi , Zhang Feng , Lu Lu 
Published: October 2019

AbstractStudies have shown that microRNAs (miRNAs) participate in almost all pathological and physiological processes including acute lower‐extremity deep venous thrombosis (LEDVT). Here, this study was designed to elucidate the possible function of miR‐103a‐3p in acute LEDVT. Expression of miR‐103a‐3p and chemokine C‐X‐C motif ligand 12 (CXCL12) was initially quantified in plasma collected from 81 LEDVT patients. Then LEDVT mouse models were established by injection with 3% sodium pentobarbital. The interaction between miR‐103a‐3p and CXCL12 was identified by dual‐luciferase reporter gene assay. After gain‐ and loss‐of‐function studies, interleukin‐6 (IL‐6) and IL‐8 and tissue factor (TF) levels, and expression of plasminogen activator inhibitors (PAIs), von Willebrand factor (vWF), thromboxane A2 (TH‐A2), F4/80, IL‐12, Arginase‐1 (Arg‐1) and CD206 were determined using enzyme‐linked immunosorbent assay (ELISA), reverse transcription quantitative polymerase chain reaction (RT‐qPCR) and western blot analysis, respectively. miR‐103a‐3p was downregulated, while CXCL12 was upregulated in patients and mice with LEDVT. miR‐103a‐3p targets CXCL12 and inhibited its expression. Overexpressed miR‐103a‐3p or downregulated CXCL12 decreased expression of IL‐6, IL‐8, TF, PAIs, vWF, TH‐A2, M1 markers (IL‐6 and IL‐12), yet increased expression of M2 markers (Arg‐1 and CD206) in LEDVT mice. Additionally, upregulated miR‐103a‐3p or silencing CXCL12 suppressed thrombosis in LEDVT mice. However, overexpression of CXCL12 reversed the tendency mentioned above. Altogether, miR‐103a‐3p can potentially downregulate CXCL12 expression to disrupt inflammatory response and thrombosis, ultimately preventing the development of LEDVT. Our findings underscore a possible alternative therapeutic strategy to limit LEDVT.
Resolvin D1 reduces mitochondrial damage to photoreceptors of primary retinal cells exposed to high glucose
Authors: Trotta Maria Consiglia , Pieretti Gorizio , Petrillo Francesco , Alessio Nicola , Hermenean Anca , Maisto Rosa , D'Amico Michele 
Published: October 2019

AbstractNo study has investigated the interaction of Resolvin D1 (RvD1) with mitochondrial damage of retinal cells caused by diabetes. This study aims to investigate the effects of RvD1 (50 nM) on morphological and biochemical indicators of mitochondrial damage in primary retinal cells exposed to 30 mM d‐glucose high glucose (HG). HG‐cells exhibited photoreceptor damage characterized by short and small mitochondria with prevalent mitochondrial disruption, fragmentation, and aggregation. The cells had low mitochondrial transporters TIMM44 and TOMM40, Connexin 43, NAD/NADH ratio, and ATP levels, whereas increased cytosolic cytochrome c. Moreover, they expressed high cytosolic metalloproteinase matrix metallopeptidase 9 (MMP‐9) and MMP‐2 activity. HG‐cells treated with RvD1 (50 nM) showed reduced reactive oxygen species levels, improved mitochondrial morphology and function, promoted mitochondrial DNA repair by OGG1, and reduced cell apoptosis and metalloproteinase activity. Therefore, RvD1 induces protection from high glucose‐load to the retinal cell and promotes their survival by decreasing cytosolic MMP and mitochondrial damage.