bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Rehabilitation of Patients with Atypical Anatomical and Functional States after Radical Organ-Preserving Operations for Non-Tumour Colon Diseases
Authors: Melnyk V. M. , Poida O. I. , Kadir Abdulrakhman Abdul 
Published: November 2018

The aim of the work: to demonstrate modern possibilities and ways of providing rehabilitation of patients after radical surgical treatment of non-tumour colon diseases with available non-typical anatomical and functional states.
Materials and Methods. The system of surgical rehabilitation measures was developed, which was used in 32 patients with available atypical anatomical and functional states after radical organ-preserving operations in non-tumour colon diseases. They are aimed at implementing sufficiently radical, reconstruction and restoration operations, forecasting and preventing postoperative complications, improving functional results, reducing the incidence and severity of severe forms of diarrhea and postcolectomy syndromes.
Results and Discussion. In 2 (6.3 %) patients there were complications due to the implementation of reconstruction and restoration stage of surgical intervention. They led to the necessity of extirpation of the anal canal fistula, removal of ileoendoanal anastomosis, and the formation of a lifelong ileostomy. In 30 (93.7 %) patients, favourable functional results were obtained, and a significant level of surgical and social work rehabilitation was achieved. A significant level of rehabilitation of operated patients was achieved through the implementation of sufficiently radical and developed reconstruction and restoration operations that prevented the relapse of the disease, the emergence of pathological conditions caused by the removal of the large intestine; prognostication and purposeful prevention of severe postoperative complications, stage monitoring of the condition of operated patients.
Conclusions. 1. Surgical rehabilitation of patients operated for serious non-tumour colon diseases is a complex of organizational and therapeutic and prophylactic means aimed at returning to a society of a citizen sufficiently adapted to the conditions of modern society.

Surgical rehabilitation of patients with atypical anatomical and functional states in the radical surgical treatment of non-tumour colon diseases requires further improvement of surgical treatment methods and lifelong monitoring of the condition of operated patients.

3. Performing sufficiently radical surgical operations, developing new reconstruction and rehabilitation operations for existing non-typical anatomical and functional states contributed to the provision of favourable functional results, a significant level of surgical and social and labour rehabilitation in 93.7% of patients.
Морфометрична характеристика структурної перебудови м′язової оболонки дванадцятипалої кишки при пострезекційній портальній гіпертензії
Authors: Shulgai A. H. , Tatarchuk L. V. , Hnatjuk M. S. 
Published: November 2018

Мета роботи: морфометричними методами вивчити особливості структурної перебудови м′язової оболонки дванадцятипалої кишки при пострезекційній портальній гіпертензії.
Матеріали і методи. Комплексом морфологічних методів досліджено дванадцятипалу кишку 45 статевозрілих білих щурів-самців, які були розділені на 3-и групи. Перша група нараховувала 15 інтактних тварин, 2-а – 15 щурів, у яких було видалено 31,5 % паренхіми печінки, 3-я – 15 тварин після резекції 58, 1 % паренхіми печінки. Евтаназію щурів здійснювали кровопусканням в умовах тіопенталового наркозу через один місяць від початку експерименту. Із дванадцятипалої кишки виготовляли гістологічні мікропрепарати. Вимірювали товщини колового та поздовжнього шарів м′язової оболонки, діаметри гладких міоцитів та їх ядер, ядерно-цитоплазматичні відношення у цих клітинах, стромально-міоцитарні відношення, відносні об′єми пошкоджених міоцитів.
Результати досліджень та їх обговорення. Встановлено, що через місяць після резекції 31,5 % паренхіми печінки досліджувані морфометричні показники змінювалися незначно. Видалення 58,1 % паренхіми печінки призводило до розвитку пострезекційної портальної гіпертензії. Виражено зміненими при цьому виявилися морфометричні параметри структур колового та поздовжнього шарів м’язової оболонки дванадцятипалої кишки. Товщина колового шару м’язової оболонки через місяць після резекції 58,1 % паренхіми печінки статистично достовірно зменшилася на 5,0 %, діаметр міоцитів – на 8,7 %, ядерно-цитоплазматичні відношення у них зросли на 42,8 %, cтромально-міоцитарні відношення –на 21 %, відносний об’єм пошкоджених міоцитів – у 15,9 раза. Кількісні морфологічні показники структур поздовжнього шару м’язової оболонки дванадцятипалої кишки через місяць після резекції 58,1 % паренхіми печінки змінювалися аналогічно, але ступінь їх вираження був меншим порівняно із структурами колового шару. Так, діаметр міоцитів у даних експериментальних умовах виявився зменшеним всього на 0,92 %, діаметр ядер зріс на 7,1 % (р<0,05), ядерно-цитоплазматичні відношення – на 16,8 % (р<0,001), стромально-міоцитарні відношення – на 14,7 %, відносний об’єм пошкоджених міоцитів – у 9,3 раза. Результати проведеного дослідження стверджують, що видалення великих об’ємів паренхіми печінки призводить до пострезеційної портальної гіпертензії та вираженої морфологічної перебудови (ремоделювання) структур колового та поздовжнього шарів м’язової оболонки дванадцятипалої кишки, яке характеризується диспропорційними нерівномірними змінами морфометричних параметрів гладких міоцитів, їх ядер, порушеннями ядерно-цитолазматичних відношень у цих клітинах, атрофією, зростанням стромальних структур та відносних об’ємів пошкоджених міоцитів у м′язовій оболонці, що може ускладнюватися дисфункцією ушкодженого органа.
Лікування бойової травми в цивільного населення
Authors: Vrublevskyi O. 
Published: November 2018

Дана праця спирається на особистий досвід автора під час гуманітарних місій та є спробою узагальнення результатів понад 1800 операцій, виконаних за останні три роки в “гарячих точках” світу.
Динаміка показників гепатодепресивного синдрому у хворих з механічною жовтяницею пухлинного ґенезу після ендоскопічної і лапароскопічної паліативної декомпресії загальної жовчної протоки
Authors: Nychitaylo M. Y. , Kondratiuk A. P. , Khilko Yu. A. , Ogorodnyk P. V. , Deinychenko A. G. , Kondratiuk V. A. , Yermak N. A. , Yusupov T. A. 
Published: November 2018

Мета роботи з’ясувати динаміку показників гепатодепресивного синдрому у хворих із механічною жовтяницею пухлинного генезу після ендоскопічної і лапароскопічної паліативної декомпресії загальної жовчної протоки.
Матеріали і методи. Під спостереженням в період з 2011 до 2017 р. перебували 48 пацієнтів, в яких внаслідок комплексного обстеження виявили інкурабельні пухлини на тлі вираженої механічної жовтяниці. Усім хворим виконано паліативну декомпресію загальної жовчної протоки: 30 пацієнтів – із застосуванням ендоскопічних методів; 18 пацієнтів – із використанням лапароскопічної гепатикоєюностомії. Кожну підгрупу рандомізували за віком, статтю, тривалістю жовтяничного періоду та основними біохімічними показниками, визначеними до операції. Пацієнти перебували під спостереженням протягом 6 міс. після декомпресії. До операції, через 1, 7 і 14 діб, а також 3 і 6 міс. у пацієнтів визначали маркери гепатодепресивного синдрому: протромбіновий час, вміст загального білка й альбумінів у сироватці крові за загальновідомими методами.
Результати досліджень та їх обговорення. Лапароскопічна декомпресія загальної жовчної протоки шляхом формування гепатикоєюноанастомозу порівняно з ендоскопічними методами супроводжується швидшим відновленням функціонального стану печінки, що проявляється сталим зниженням протромбінового часу індексу INR і збільшенням вмісту в сироватці крові загального білка та альбумінів через 3–6 міс. після декомпресії. На тлі ендоскопічної декомпресії в цей період протромбіновий час і індекс INR статистично вірогідно більші, вміст у сироватці крові загального білка і альбумінів – менший, порівняно з лапароскопічною декомпресією. Через 3-6 міс. після втручання за умов ендоскопічної декомпресії показники гепатодепресивного синдрому суттєво погіршуються, що пов’язано з розвитком у 30 % пацієнтів ускладнень.
A new species of Tricholosporum (Agaricales, Tricholomataceae) from Liaoning Province of China
Authors: XU JIZE , ZHANG CHUNLAN , KASUYA TAIGA , MOODLEY ODESHNEE , LIU BAO , GONG LEI , LI YU 
Published: November 2018

Tricholosporum haitangshanum sp. nov. is described as a new species from China, based on morphological and molecular data. It is morphologically characterized by a yellowish ochre pileus, cruciate basidiospores and ampullaceous cystidia. Phylogenetic analyses based on the nuc rDNA internal transcribed spacer (ITS) region supports that it belongs to Tricholosporum. Comparing it with phenotypically similar and molecular phylogenetically allied taxa concluded that it is a new species in Tricholosporum.
Leisure and the Production Possibility Frontier: A Two-Step Pedagogy
Authors: Galles Gary M. , Graves Philip E. , Sexton Robert L. 
Published: November 2018

The production possibility frontier (PPF) is a workhorse of economics principles texts, providing useful insights. However, its assumption of a given amount of labor can confuse students, who know that their willingness to supply labor is a variable, not given. That is, some will realize that there are actually many potential guns-butter trade-offs, one for each level of leisure chosen. That unexamined issue can undermine student buy-in to the concepts, and with it, the usefulness of the PPF and economic tools related to it and its “fixed amount of resources” assumption, such as the supply curves of microeconomics and the long-run aggregate supply curve of macroeconomics. However, that difficulty can be addressed using a two-step PPF presentation, which considers the simultaneous goods-leisure decision and the guns-butter possibilities consistent with it. It clarifies the analysis, as well as offering several benefits for economic instruction. JEL Classifications: A20, A22
Case-Based PowerPoint to Improve Knowledge and Comfort of Having Code Status Discussions by Physician Assistant and Nurse Practitioner Students
Authors: Schoonover Kimberly , Herber Andrew , Heusinkvelt Sally , Yadav Hemang , Burton M. Caroline 
Published: November 2018

Background: Little is known about how certain educational interventions may improve informed code status discussions by physician assistant (PA) and nurse practitioner students. Methods: This is a prospective, prospective, single academic center pilot study utilizing a short case-based PowerPoint that reviewed the differences between code status choices and the likelihood of survival to hospital discharge of attempted resuscitation after a cardiac arrest. Training occurred between September 1, 2017, and May 31, 2018. The study population included PA and adult gerontology acute care nurse practitioner (AGACNP) students during their inpatient internal medicine rotation (n = 9) and preclinical PA students (n = 5). Results: After training, there was a significant increase in knowledge in the likelihood of survival to hospital discharge ( P = .01) and comfort level in having an informed code status discussion (3.36 ± 0.81 vs 4.10 ± 0.80, P = .02). For questions related to identification of the correct code status, there were no significant differences before and after the intervention. Conclusion: A short case-based PowerPoint viewed by PA and AGACNP students increased the knowledge about the likelihood of survival to hospital discharge of attempted resuscitation after a cardiac arrest and increased the comfort level of having code status discussions with patients by PA and AGACNP students.
Using the SGDA Framework to Design and Evaluate Research Games
Authors: Geerts David , Nouwen Marije , van Beek Evert , Slegers Karin , Chocron Miranda Fernanda , Bleumers Lizzy 
Published: November 2018

Background. Several HCI researchers have started to use game design elements in their research to create playful methods for involving end-users in design. Similar to serious games, such research games serve a dual purpose: 1) to create an enjoyable experience for research participants, and 2) to collect user insights to inform the design process. Aim. We propose that the Serious Game Design Assessment (SGDA) Framework, that evaluates both a game’s enjoyable purposes and its serious purposes, may be a valuable tool in assessing and developing research games. In this article, we apply the SGDA Framework to three existing research games, one involving train passengers in assessing potential future user experiences, one involving hospital staff in ideation for wearable technology, and one involving TV viewers in ideation for future video watching scenarios. Conclusion. The assessment of the three research games suggests that the framework is indeed applicable to research games and may, as such, provide HCI researchers with clear guidance when creating new research games.
MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7
Authors: He Huiping , Liao Xianghui , Yang Qingmei , Liu Yuan , Peng Yan , Zhong Hongzhen , Yang Jun , Zhang Huiqing , Yu Zhonghua , Zuo Yufang , Guan Chengnong , Xu Zumin 
Published: November 2018

Background: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharyngeal carcinoma. However, little is known about the function and mechanism of miR-494-3p in nasopharyngeal carcinoma. In the present study, we aimed to investigate the effects of miR-494-3p on the migration and invasion of nasopharyngeal carcinoma and to further explore the underlying mechanisms of these processes. Methods: The expression levels of miR-494-3p and Sox7 in nasopharyngeal carcinoma specimens and nasopharyngeal carcinoma cell lines were measured using quantitative reverse transcription polymerase chain reaction. Luciferase reporter assay, quantitative reverse transcription polymerase chain reaction, and Western blotting were used to confirm whether Sox7 was a direct target of miR-494-3p. Additionally, the roles of miR-494-3p and Sox7 on cell proliferation, migration, and invasion of nasopharyngeal carcinoma were analyzed by Cell Counting Kit-8 (CCK-8) assay, wound healing assay, and Boyden chamber assay, respectively. Results: Our study demonstrated that miR-494-3p was commonly upregulated in nasopharyngeal carcinoma specimens and nasopharyngeal carcinoma cell lines compared with nontumor nasopharyngeal epithelial tissue or nasopharyngeal cells (NP69). Moreover, miR-494-3p negatively regulated Sox7 at the posttranscriptional level by binding to a specific site in the Sox7 3′-untranslated region. In addition, synthetic miR-494-3p mimics significantly promoted proliferation, migration, and invasion of S18 and S26 nasopharyngeal carcinoma cells, while a synthetic miR-494-3p inhibitor resulted in suppressed nasopharyngeal carcinoma cell migration and invasion. Conclusion: miR-494-3p promotes nasopharyngeal carcinoma cell growth, migration, and invasion by directly targeting Sox7. Our results suggest that miR-494-3p might be a potential therapeutic target for nasopharyngeal carcinoma.
Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex
Authors: Fan Yong-fei , Guan Shao-yu , Luo Li , Li Yan-jiao , Yang Le , Zhou Xuan-xuan , Guo Guo-dong , Zhao Ming-gao , Yang Qi , Liu Gang 
Published: November 2018

Tetrahydroxystilbene glucoside (THSG) is one of the active ingredients of Polygonum multiflorum. It has been shown to exert a variety of pharmacological effects, including antioxidant, anti-aging, and anti-atherosclerosis. Because of its prominent anti-inflammatory effect, we explored whether THSG had analgesic effect. In this study, we used a model of chronic inflammatory pain caused by injecting complete Freund’s adjuvant into the hind paw of mice. We found THSG relieved swelling and pain in the hind paw of mice on a dose-dependent manner. In the anterior cingulate cortex, THSG suppressed the upregulation of GluN2B-containing N-methyl-D-aspartate receptors and the downregulation of GluN2A-containing N-methyl-D-aspartate receptors caused by chronic inflammation. In addition, THSG increased Bcl-2 and decreased Bax and Caspase-3 expression by protecting neuronal survival. Furthermore, THSG inhibited the phosphorylation of p38 and the increase of nuclear factor κB (NF-κB) and tumor necrosis factor α (TNF-α). Immunohistochemical staining revealed that THSG blocked the activation of microglia and reduced the release of proinflammatory cytokines TNF-α, interleukin 1β (IL-1β), and interleukin 6 (IL-6). In conclusion, this study demonstrated that THSG had a certain effect on alleviating complete Freund’s adjuvant-induced chronic inflammatory pain.
Association Between Room Location and Adverse Outcomes in Hospitalized Patients
Authors: Mayampurath Anoop , Ward Christopher , Fahrenbach John , LaFond Cynthia , Howell Michael , Churpek Matthew M. 
Published: November 2018

Objective: To investigate whether a patient’s proximity to the nurse’s station or ward entrance at time of admission was associated with increased risk of adverse outcomes. Method: We conducted a retrospective cohort study of consecutive adult inpatients to 13 medical–surgical wards at an academic hospital from 2009 to 2013. Proximity of admission room to the nurse’s station and to the ward entrance was measured using Euclidean distances. Outcomes of interest include development of critical illness (defined as cardiac arrests or transfer to an intensive care unit), inhospital mortality, and increase in length of stay (LOS). Results: Of the 83,635 admissions, 4,129 developed critical illness and 1,316 died. The median LOS was 3 days. After adjusting for admission severity of illness, ward, shift, and year, we found no relationship between proximity at admission to nurse’s station our outcomes. However, patients admitted to end of the ward had higher risk of developing critical illness (odds ratio [ OR] = 1.15, 95% confidence interval [CI] = [1.08, 1.23]), mortality ( OR = 1.16, 95% CI [1.03, 1.33]), and a higher LOS (13-hr increase, 95% CI [10, 15] hours) compared to patients admitted closer to the ward entrance. Similar results were observed in sensitivity analyses adjusting for isolation room patients and considering patients without room transfers in the first 48 hr. Conclusions: Our study suggests that being away from the nurse’s station did not increase the risk of these adverse events in ward patients, but being farther from the ward entrance was associated with increase in risk of adverse outcomes. Patient safety can be improved by recognizing this additional risk factor.
Functional redundancy between RAP1 isoforms in murine platelet production and function
Authors: Stefanini Lucia , Lee Robert H. , Paul David S. , O'Shaughnessy Ellen C. , Ghalloussi Dorsaf , Jones Christopher I. , Boulaftali Yacine , Poe Kathryn O. , Piatt Raymond , Kechele Dan O. , Caron Kathleen M. , Hahn Klaus M. , Gibbins Jonathan M. , Bergmeier Wolfgang 
Published: November 2018

Key Points
Deletion of both Rap1a and Rap1b impairs platelet production and abolishes platelet adhesion at sites of mechanical trauma. Platelet RAP1 signaling is dispensable for vascular integrity during development and at sites of inflammation.
Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu
Authors: Chen Xuejie , Jin Da-Yun , Stafford Darrel W. , Tie Jian-Ke 
Published: November 2018

Key PointsAcenocoumarol is the most efficient oral anticoagulant with the least variation of resistance among naturally occurring VKOR mutations. Warfarin and fluindione are equipotent for anticoagulation control but have different mechanisms of action on VKOR inactivation.
Reducing gravity data for the influence of water storage variations beneath observatory buildings
Authors: Reich Marvin , Mikolaj Michal , Blume Theresa , Güntner Andreas 
Published: November 2018

Ground-based gravimetry is increasingly used to study mass distributions and mass transport below the earth surface. The gravity effect of local water storage variations can be large and should be accounted for in the interpretation of these data. However, the effect of hydrologic mass changes in the immediate vicinity of the gravimeter is not considered in standard routines for separating unwanted signal components. This applies in particular to the effect of the buildings in which gravimeters are installed. The building shields the underlying soil from precipitation and evapotranspiration and thus directly affects the water storage dynamics in the near-field of the gravimeter. A combined approach of in situ soil moisture observations and hydrologic modeling was used to quantify the altered water storage variations below observatory buildings. Subsequently, the errors caused by different estimation approaches for this umbrella effect in hydrogravitational computations were assessed. Depending on the site characteristics, the errors range from 4.1 to [Formula: see text] for the intra-annual amplitude when natural soil moisture data are considered for modeling the umbrella effect, and they range from 4.1 to [Formula: see text] when assuming no gravity change within 5 m below the building. These results were condensed to general recommendations, leading to a new simple and broadly applicable method to reduce observed gravity data for building effects, given basic information about the gravimeter location, building dimensions, climatic regime, and soil type of the observation site. This new reduction approach indicates errors of the intra-annual amplitude from 1.9 to [Formula: see text].
Dynamic mechanisms of lamina-induced fracture propagation in tight oil-sand formations
Authors: Liu Dan , Li Yaohua , Luo Qun , Wang Qianyou , Meng Xiangzhen , Ge Yunjin , Luo Jiaguo , Feng Hairu , Li Yang , Zhang Xin 
Published: November 2018

Lamina-induced fractures (LFs) are abundant in lacustrine formations, playing an important role in tight oil resource exploration. There is a lack of research on the dynamic mechanisms of LF propagation in heterogeneous formations characterized by complex combinations of lamina and surrounding rock. For this reason, we conducted triaxial compressive tests of 28 long column samples and Brazil split tests of 37 short column samples using six core samples with different lithologies, including nine column samples tested using a CT scanner and an acoustic emission apparatus. We designed this experiment to study the LF propagation process and its dynamic mechanisms within different lithologies. Our results show that (1) we classified three mechanical LF types based on the relationship between stress state and lamina angle: tensile LF (T-LF), shear LF (S-LF), and hybrid LF (H-LF); (2) H-LF only propagated in the middle lamina angle range (approximately 11°–64°); T-LF was inclined to propagate in the low lamina angles; and S-LF was inclined to propagate in the high lamina angles; and (3) in the Ordos Basin, T-LF, TF, and SF propagated mutually in outcrops with low confining pressures. T-LF, H-LF, and SF propagated mutually in the Yanchang Formation, an outcrop that greatly contributes to tight oil sweet spot exploration. Furthermore, unlike the in situ accumulation theory, we find that it is possible for hydrocarbon migration to occur in tight reservoir formations, in which the LF acts as a hydrocarbon migration pathway during the tectonic phase.