bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression Levels of the Tyrosine Hydroxylase Gene and Histone Modifications Around its Promoter in the Locus Coeruleus and Ventral Tegmental Area of Rats during Forced Abstinence from Morphine
Authors: Jalali Mashayekhi Farideh , Rasti Mozhgan , Khoshdel Zahra , Owji Ali Akbar 
Published: December 2018

<b><i>Background:</i></b> Epigenetic mechanisms such as histone modifications may be involved in the structural and behavioral changes associated with addiction. We studied whether morphine-induced changes in mRNA levels of the catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are associated with histone modifications around the promoter of this gene in the locus coeruleus (LC) and ventral tegmental area (VTA) of rats. <b><i>Methods:</i></b> Dependence was induced in rats by intraperitoneal injections of morphine for 11 days. The animals were killed 2 h (chronic morphine), 24 h and 7 days (spontaneous withdrawal) after the last injection of morphine. <b><i>Results:</i></b> Analysis of our real-time quantitative reverse transcription PCR results by 1-way ANOVA showed significant upregulation (5.13 ± 0.39 folds) of LC levels of the TH transcript 24 h after the last injection of morphine to rats, when compared with 2 h and 7 days time points. Chronic morphine and morphine abstinence failed to cause any significant changes in the levels of TH mRNA in the VTA after cessation of morphine. Consistently, chromatin immunoprecipitation real-time quantitative PCR assays revealed that 24 h after the last injection of morphine, levels of H3 acetylation were significantly increased (4.12 ± 0.38 folds) at the promoter of the TH gene in the LC but not in the VTA. Our data also showed that histone H3 trimethylation failed to change around the TH gene promoter either in the VTA or in the LC after morphine abstinence. <b><i>Conclusions:</i></b> Results of the present study, for the first time, demonstrate the involvement of histone H3 acetylation in the regulation of TH gene expression in the LC of rats during forced abstinence from morphine.
Reconstructing the Drizzle Mode of the Raindrop Size Distribution Using Double-Moment Normalization
Authors: Raupach Timothy H. , Thurai Merhala , Bringi V. N. , Berne Alexis 
Published: December 2018

AbstractCommonly used disdrometers tend not to accurately measure concentrations of very small drops in the raindrop size distribution (DSD), either through truncation of the DSD at the small-drop end or because of large uncertainties on these measurements. Recent studies have shown that, as a result of these inaccuracies, many if not most ground-based disdrometers do not capture the “drizzle mode” of precipitation, which consists of large concentrations of small drops and is often separated from the main part of the DSD by a shoulder region. We present a technique for reconstructing the drizzle mode of the DSD from “incomplete” measurements in which the drizzle mode is not present. Two statistical moments of the DSD that are well measured by standard disdrometers are identified and used with a double-moment normalized DSD function that describes the DSD shape. A model representing the double-moment normalized DSD is trained using measurements of DSD spectra that contain the drizzle mode obtained using collocated Meteorological Particle Spectrometer and 2D video disdrometer instruments. The best-fitting model is shown to depend on temporal resolution. The result is a method to estimate, from truncated or uncertain measurements of the DSD, a more complete DSD that includes the drizzle mode. The technique reduces bias on low-order moments of the DSD that influence important bulk variables such as the total drop concentration and mass-weighted mean drop diameter. The reconstruction is flexible and often produces better rain-rate estimations than a previous DSD correction routine, particularly for light rain.
Behavioral Changes to Repeated Takeovers in Highly Automated Driving: Effects of the Takeover-Request Design and the Nondriving-Related Task Modality
Authors: Roche Fabienne , Somieski Anna , Brandenburg Stefan 
Published: December 2018

Objective: We investigated drivers’ behavior and subjective experience when repeatedly taking over their vehicles’ control depending on the design of the takeover request (TOR) and the modality of the nondriving-related task (NDRT). Background: Previous research has shown that taking over vehicle control after highly automated driving provides several problems for drivers. There is evidence that the TOR design and the NDRT modality may influence takeover behavior and that driver behavior changes with more experience. Method: Forty participants were requested to resume control of their simulated vehicle six times. The TOR design (auditory or visual-auditory) and the NDRT modality (auditory or visual) were varied. Drivers’ takeover behavior, gaze patterns, and subjective workload were recorded and analyzed. Results: Results suggest that drivers change their behavior to the repeated experience of takeover situations. An auditory TOR leads to safer takeover behavior than a visual-auditory TOR. And with an auditory TOR, the takeover behavior improves with experience. Engaging in the visually demanding NDRT leads to fewer gazes on the road than the auditory NDRT. Participants’ fixation duration on the road decreased over the three takeovers with the visually demanding NDRT. Conclusions: The results imply that (a) drivers change their behavior to repeated takeovers, (b) auditory TOR designs might be preferable over visual-auditory TOR designs, and (c) auditory demanding NDRTs allow drivers to focus more on the driving scene. Application: The results of the present study can be used to design TORs and determine allowed NDRTs in highly automated driving.
Meal frequency and vegetable intake does not predict the development of frailty in older adults
Authors: Johannesson Julie , Rothenberg Elisabet , Gustafsson Susanne , Slinde Frode 
Published: December 2018

Background: Frailty is considered highly prevalent among the aging population. Fruit and vegetable intake is associated with positive health outcomes across the life-span; however, the relationship with health benefits among older adults has received little attention. Aim: The aim was to examine if a relationship exists between meal frequency or frequency of vegetable intake and the development of frailty in a population of older adults. Methods: A total of 371 individuals, 80 years or older, from the study ‘Elderly Persons in the Risk Zone’ were included. Data was collected in the participants’ home by face-to-face interviews up to 24 months after the intervention. Baseline data were calculated using Chi2-test; statistical significance was accepted at the 5% level. Binary logistic regression was used for the relationship between meal frequency or vegetable intake and frailty. Results: Mean meal frequency was 4.2 ± 0.9 meals per day; women seem to have a somewhat higher meal frequency than men (p=0.02); 57% of the participants had vegetables with at least one meal per day. No significant relationship was found between meal frequency or vegetable intake and frailty at 12 or 24 months follow-ups. Conclusions: Among this group of older adults (80+), meal frequency was slightly higher among women than men, and just over half of the participants had vegetables with at least one meal a day. The risk of developing frailty was not associated with meal frequency or vegetable intake. The questions in this study were meant as indicators for healthy food habits.
The effect of group exercises on balance, mobility, and depressive symptoms in older adults with mild cognitive impairment: a randomized controlled trial
Authors: Langoni Chandra da Silveira , Resende Thais de Lima , Barcellos Andressa Bombardi , Cecchele Betina , da Rosa Juliana Nunes , Knob Mateus Soares , Silva Tatiane do Nascimento , Diogo Tamiris de Souza , da Silva Irenio Gomes , Schwanke Carla Helena Augustin 
Published: December 2018

Objective: To determine the effects of group exercises on balance, mobility, and depressive symptoms in community-dwelling older adults with mild cognitive impairment. Design: Single blinded, randomized, matched pairs clinical trial. Setting: Four primary healthcare units. Subjects: Fifty-two sedentary subjects with mild cognitive impairment were paired (age, sex, body mass index, and Addenbrooke’s Cognitive Examination Revised score), tested, and then randomized into an intervention group ( n = 26) and a control group ( n = 26). Intervention: The intervention group performed strength (ankle weights, elastic bands, and dumbbells) and aerobic exercises (walking) in their communities’ public spaces, twice a week (60 minutes each), during 24 weeks. The control group maintained its usual routine. Main measures: Balance (Berg Balance Scale (BBS)), mobility (Timed Up and Go Test (TUG)), and depressive symptoms (Geriatric Depression Scale-15) were assessed before and after the intervention. Results: Before the intervention, the two groups did not differ statistically. After, the intervention group showed significant improvement ( P < 0.05) in balance (before: 53 ± 3; after: 55.1 ± 1.1 points), mobility (before: 10.7 ± 2.9 seconds; after: 8.3 ± 2 seconds), and depressive symptoms (median punctuation (interquartile range) before: 4 (1.8–6); after: 2.5 (1–4)). The control group presented a significant increase in their depressive symptoms (median before: 3.5 (2–7.3); after: 4 (2–5.3)), while their balance and mobility showed no significant modification. Small effect sizes were observed in the intervention group and control group depressive symptoms, as well as in the control group’s mobility and balance. Large effect sizes were observed the intervention group’s mobility and balance. Conclusion: Group exercises improved balance, mobility, and depressive symptoms in community-dwelling older adults with mild cognitive impairment.
A qualitative study exploring therapists’ experiences of implementing a complex intervention promoting meaningful activity for residents in care homes
Authors: Smith Raymond , Wood Julia , Jones Fiona , Turner Sue , Hurley Michael 
Published: December 2018

Objectives: To explore the experiences of occupational therapists and physiotherapists and to reveal any factors that can facilitate delivering a complex care home intervention promoting meaningful activity. Design: Qualitative interview study using data from three focus groups conducted longitudinally post intervention implementation. Data were analysed thematically. Setting: Three residential care homes in South London, UK. Subjects: All therapists involved in the implementation of the intervention: three occupational therapists and three physiotherapists. Results: Three interconnected themes emerged from the analysis: (1) developing trusting relationships, (2) empowering staff and (3) remaining flexible. Therapists described how successfully implementing a complex care home intervention was dependant on developing trusting relationships with care staff. This enabled the therapists to empower care staff to take ownership of the intervention and help embed it in care home culture, facilitating long-term change. The therapists described how remaining flexible in their approach helped keep care staff engaged for the duration of implementation. Conclusion: This study has revealed several important factors that can help facilitate therapists delivering complex interventions in care homes.
Short-term effects of neuromuscular electrical stimulation and ultrasound therapies on muscle architecture and functional capacity in knee osteoarthritis: a randomized study
Authors: Devrimsel Gul , Metin Yavuz , Serdaroglu Beyazal Munevver 
Published: December 2018

Objective: To determine the effects of ultrasound therapy and neuromuscular electrical stimulation (NMES) application on the muscle architecture and functional capacity in patients with knee osteoarthritis. Design: A randomized study. Subjects: A total of 60 patients with knee osteoarthritis. Interventions: Participants were randomized into one of the following two intervention groups, five days a week, for three weeks: the combination of NMES application, hot pack, and exercise therapy was applied to the NMES group. The combination of therapeutic ultrasound, hot pack and exercise therapy was applied to the ultrasound therapy group. Main measures: Subjects were evaluated for pain and functional capacity with the use of the visual analog pain scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and 15 meter walking test. The muscle architecture (muscle thickness, pennation angle and fascicle length) was assessed from vastus lateralis and quadriceps femoris muscles bilaterally by ultrasonography. Results: Two groups presented significant improvements in all outcome measures before and after treatment ( P < 0.01). There were significant improvements in VAS rest pain ( P < 0.05), VAS activity pain ( P < 0.05), WOMAC pain ( P < 0.05), WOMAC stiffness score ( P < 0.05), and WOMAC physical function ( P < 0.05) for the ultrasound therapy group in comparison to the NMES group. NMES group exhibited more increases in the muscle thickness and fascicle length values when compared to ultrasound therapy group ( P < 0.05). Conclusion: Ultrasound therapy appears to be an effective treatment in reducing pain and improving functional capacity. NMES application has more effects on the muscle architecture.
BAG3 contributes to HGF-mediated cell proliferation, migration, and invasion via the Egr1 pathway in gastric cancer
Authors: Lee Jae Chang , Koh Sung Ae , Lee Kyung Hee , Kim Jae-Ryong 
Published: December 2018

Introduction: Bcl2-associated athanogene 3 (BAG3) is elevated in several types of cancers. However, the role of BAG3 in progression of gastric cancer is unknown. Therefore, the present study aims to find out the role of BAG3 in hepatocyte growth factor (HGF)–mediated tumor progression and the molecular mechanisms by which HGF regulates BAG3 expression. Methods: BAG3 mRNA and protein were measured using reverse transcription polymerase chain reaction and Western blot in the 2 human gastric cancer cell lines, NUGC3 and MKN28, treated with or without HGF. The effects of BAG3 knockdown on cell proliferation, cell invasion, and apoptosis were analyzed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the in vitro 2-chamber invasion assay, and flow cytometry in BAG3 short hairpin RNA (shRNA)–transfected cells and control cells. The signaling pathways involved in BAG3 that are regulated by HGF were analyzed. The chromatin immunoprecipitation assay was used to determine binding of Egr1 to the BAG3 promoter. Results: BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. Conclusion: This pathway may provide novel therapeutic targets and provide information for further identification of other targets of therapeutic significance in gastric cancer.
Breastfeeding Self-Efficacy Among Parturient Women in Shanghai: A Cross-Sectional Study
Authors: Li Tengteng , Guo Nafei , Jiang Hui , Eldadah Maher 
Published: December 2018

Background: Breastfeeding self-efficacy has been shown to be a strong predictor of breastfeeding initiation and duration; however, factors associated with breastfeeding self-efficacy in China are unclear. Research aims: The aims were (a) to describe the breastfeeding self-efficacy of parturient women in Shanghai, China and (b) to identify the sociodemographic factors associated with mothers’ breastfeeding self-efficacy. Methods: This is a cross-sectional retrospective descriptive study. Through convenience sampling, breastfeeding mothers ( N = 801) were recruited to assess breastfeeding self-efficacy before discharge from the hospital. Descriptive statistics were used to analyze the sociodemographic and perinatal characteristics, level of breastfeeding self-efficacy, and correlations between them. Results: In the process of breastfeeding, 52.2% ( n = 418) of participants encountered breastfeeding problems, 37.1% ( n = 297) perceived an insufficient milk supply, 82.4% ( n = 660) reported attending breastfeeding classes, but only 37.1% ( n = 297) chose exclusive breastfeeding. Chinese mothers reported a moderate level of breastfeeding self-efficacy, with an item mean score of 3.67 (score = 1–5). Whether or not encountering breastfeeding problems, infant feeding pattern (fully breastfeeding, partial breastfeeding, no breastfeeding) in the previous 24 hours, whether or not perceiving insufficient milk, and main caregiver’s positive attitude toward breastfeeding (ranging from 1 to10, higher score indicating more positive attitude) were correlated with participants’ breastfeeding self-efficacy score. (The correlation coefficients were −0.432, 0.377, −0.364, and 0.353, respectively.) Conclusion: The misperception of insufficient milk and main caregiver’s attitude toward breastfeeding were important factors for breastfeeding self-efficacy. Greater efforts should be made during breastfeeding education and support.
Intense regulated pulse light for the meibomian gland dysfunction
Authors: Karaca Emine Esra , Evren Kemer Özlem , Özek Dilay 
Published: December 2018

Purpose: To assess the effect of intense regulated pulse light (E-Eye; E-Swin, France) on the treatment of meibomian gland dysfunction. Setting: Health Sciences University, Ankara Numune Training and Research Hospital, Department of Ophthalmology. Methods: A total of 26 patients underwent intense pulsed light treatment (E-Eye; E-Swin), with homogeneously sequenced five light pulses delivered to one eye at 1, 15, and 45 days following baseline evaluation. At each visit, subjective clinical parameters (ocular surface disease index questionnaire and standard patient evaluation of eye dryness questionnaire) and objective clinical parameters (Schirmer I test scores, tear break-up times, Oxford grading, lid margin abnormality score, secretion quality and expressibility degree) were recorded. The subjective and objective parameters at Days 15 and 45 were compared with baseline values. Results: Patients underwent three sessions of intense pulsed light treatment. Schirmer test and tear break-up time improved significantly from baseline to Day (D) 45 (8.53 ± 4.31 mm vs 12.6 ± 3.14 mm, 4.53 ± 1.33 sn vs 11.07 ± 2.87 sn, p = 0.003 and p < 0.001). Ocular surface disease index and standard patient evaluation of eye dryness scores improved from baseline to D15 and baseline to D45 (all with p < 0.05). All the subjects reported reduced symptoms by D45. There were no cases of adverse ocular effects. There was no significant change in Oxford grading, lid margin abnormality score, secretion quality, and expressibility degree. Conclusions: Intense regulated pulse light seems a safe treatment procedure for meibomian gland dysfunction, improving tear film quality and reducing symptoms of dry eye.
Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?
Authors: Abu Baker Fadi , Mari Amir , Feldman Dan , Suki Muhammad , Gal Oren , Kopelman Yael 
Published: December 2018

Background: Melanosis coli, a brown discoloration of colonic mucosa, is considered as a benign condition mainly observed in patients under chronic anthranoid laxatives. Recent data link this condition with an increased adenoma detection rate. Moreover, its tumorigenic potential and possible association with the development of colorectal cancer remains uncertain. We conducted this study to compare the polyp detection rate and colorectal cancer diagnosis in patients with melanosis against matched control group without melanosis. Patients and methods: A retrospective single-center study. Patients diagnosed with melanosis coli on colonoscopy over a 15-year period were included. Each melanosis coli patient was matched with three controls by age, gender, setting (inpatient/outpatient), and procedure’s indication. Polyp detection rate and diagnosis of colorectal cancer were recorded and compared between the groups before and after adjustment for bowel preparation. Results: A cohort of 718 patients with melanosis and 2154 controls were included. The polyp detection rates were 33.4% and 21.8% of melanosis and control groups, respectively ( P < .001). Melanosis coli, however, was associated with less diagnosis of colorectal cancer than controls (0.3% vs 3.9%; P < .001). In multivariate analysis, melanosis diagnosis on endoscopy was significantly associated with higher polyp detection rate (odds ratio [OR] = 1.986, 95% confidence interval [CI]: 1.626-2.425; P value < .01). Conclusions: Melanosis coli is not associated with increased diagnosis of colorectal cancer. It is associated, however, with enhanced polyp detection likely due to chromo-endoscopy-like effect.
Shared core meanings and shared associations in bilingual semantic memory: Evidence from research on implicit memory
Authors: Francis Wendy S 
Published: December 2018

Aims and objectives/purpose/research questions: The degree of overlap across languages in bilingual semantic memory has been debated in the cognitive bilingual literature for decades. This paper focuses on theory and recent evidence addressing the questions of whether translation-equivalent words in a bilingual person’s two languages access common core-meaning representations and whether long-standing semantic/conceptual associations among words are language-general or language-specific. Design/methodology/approach: We explain a theoretical approach to this problem and review recent evidence that addresses it. The empirical work cited used primarily memory tasks in which the languages of the word stimuli or responses changed from encoding to test. Data and analysis: Several studies are reviewed. In most cases, data were analyzed using an analysis of variance. Findings/conclusions: Robust between-language priming was observed for concrete nouns, abstract nouns, verbs, and adjectives using a variety of specific tasks, indicating that the semantic representations of translation equivalents overlap. The reduction in priming relative to within-language conditions could be explained in some cases by repetition of language-specific processes in the within-language conditions. Results of repetition-priming and false-memory experiments that involved semantic associations showed that category–exemplar, noun–verb, antonym, and other semantic relationships are shared across languages in a common semantic system. Originality: Many of the results are interpreted with respect to questions that have not been addressed in previous work. Significance/implications: The nature of semantic system integration is important for understanding bilingual cognition. Episodic memory tasks can be a useful way to study the organization of core-meaning representations in bilinguals, and indicate that these representations are shared across languages. However, these procedures do not capture other aspects of semantic representation that may differ across languages.