bluuebunny/crossref_metadata_2025_split huggingface dataset:
The IPOET matrix: measuring resource integration
Authors: Sund Kristian Johan , Barnes Stuart , Mattsson Jan 
Published: August 2018

PurposeThe recently developed resource orchestration theory studies the processes by which managers handle resources to create competitive advantages. According to this theory, it is the way that resources interact with each other that results in such advantages. Resource integration, i.e. the alignment, or fit between resources, is one important outcome of resource orchestration processes. This paper aims to develop a scale and outline approaches to measuring such resource integration.Design/methodology/approachUsing a typology of five types of resources derived from value theory, the authors develop a scale for measuring the fit between resource types, i.e. the degree of resource integration. The authors illustrate the method using a case example of an IT company and demonstrate how a variety of statistical methods including hierarchical cluster analysis, structural equation modeling, social network analysis and methods from biostatistics can provide measures of resource integration.FindingsThe authors develop a scale and associated measures that can help scholars systematically measure and identify firms with a high or low level of resource integration capability. This makes it possible to investigate further these companies and reconstruct how they support dynamic capabilities, as well as commonalities across firms with high and low levels of this capability.Originality/valueExisting studies on resource orchestration have failed to provide us with a reliable measurement instrument that can be used both in cross-sectional work, and in repeated or time-series studies, allowing us to assess the degree to which a wider range of resources in an organization are integrated. The authors develop and demonstrate such an instrument.
Workplace information literacy skills
Authors: Ali Muhammad Yousuf , Richardson Joanna 
Published: August 2018

PurposeThe purpose of this study is to investigate the level of information literacy (IL) skills competency among university library professionals in Karachi, Pakistan and to address areas of concern.Design/methodology/approachAn online survey was designed, using Google Forms, to collect data from 77 academic librarians working in 25 universities in Karachi, Pakistan. The questions covered six generic attributes: library systems, information resources, searching techniques, research support, IL and generic/personal attributes.FindingsThe results indicate that the librarians who were surveyed had good IL skills in information searching and locating information resources. However, the average of all survey responses was 54.17 per cent, with 12 of the 24 competencies receiving scores of less than 50 per cent, thus indicating a generally overall low level of IL competency in the workplace.Research limitations/implicationsAs the study was limited to universities in Karachi, it would be useful to apply the same methodology to other administrative units within the country. Further research is indicated on the potential impact of gender on aspects such as level of IL skills and motivation to enhance workplace competencies.Practical implicationsThe authors have suggested a number of strategies, which would be applicable globally to any university library wishing to improve the IL skills competencies of its staff.Originality/valueThere have been no previous published, non-discipline-specific, research studies on the IL skills competencies of academic librarians in Pakistan.
The influence of crystallographic orientation on wear characteristics during single abrasive diamond grit scratching on sapphire
Authors: Wu Haiyong , Huang Hui , Xu Xipeng 
Published: August 2018

Purpose
The wear of an abrasive single-crystal diamond (SCD) grit affects the machining quality of the sapphire wafer. This paper aims to investigate the influence of crystallographic orientation on the wear characteristics of SCD grit scratching on sapphire.

Design/methodology/approach
The wear characteristics of two SCD grits (SCD100 and SCD111) with different crystallographic orientations were systematically investigated. The wear mechanism involved in the scratching process was explored. The wear morphology, scratching forces and friction coefficient during the scratching process were measured and analyzed.

Findings
The experiment results show that the wear progress of the two SCD grits is obviously different. The wear resistance of SCD111 grit is greater than that of SCD100 grit in normal wear stage. However, the SCD100 grit could remove more sapphire material than SCD111 grit. The SCD grits mainly sustain extrusion stress and shear stress during scratching on sapphire. The crystallographic orientation of SCD grits plays a significant role in the wear progress during scratching on sapphire.

Originality/value
The results of the experimental studies could provide a theoretical foundation for improving the fabrication of abrasive diamond tools.
A comparative study of disaster management information systems
Authors: Rafi Muhammad Masood , Aziz Tariq , Lodi Sarosh Hashmat 
Published: August 2018

PurposeDisaster management information systems (DMISs) have been proposed in different parts of the world for effective response to a disaster. The purpose of this paper is to: compare design approaches of these DMISs; examine similarities in the design of databases and communication infrastructure; and draw conclusions. Based on the examination of the studies, future opportunities have been identified and discussed.Design/methodology/approachThe studies in the available literature on the designs of automated DMISs have been reviewed in the presented paper to identify similarities in design premise, conceptual design and design considerations.FindingsThe examination of the available studies indicates that the research on DMIS has increased significantly in different countries of the world since 2004. Data of baseline information and available resources are required by most of the presented studies, as these data are necessary for effective response to a disaster. The communication infrastructures suggested include local area network, wide area network and satellite communication for better coordination between the responders and different relief agencies at different locations. The connectivity to these networks is possible through Ethernet, Wi-Fi, general packet radio service or satellite.Research limitations/implicationsAlthough the research on DMIS has increased significantly over the last one decade, the studies are still few in numbers. Similarly, only few of the proposed systems have been developed and tested during a real disaster.Practical implicationsThe presented review of available studies provides a holistic view of the proposed DMISs which could be useful to the disaster management authorities.Originality/valueThe paper provides valuable information on the differences in the proposed DMISs. This can help in identifying the gaps for future improvements for increased effectiveness of a DMIS. The future opportunities have also been identified in the presented paper and are discussed.
Stroke communication partner training: a national survey of 122 clinicians on current practice patterns and perceived implementation barriers and facilitators
Authors: Chang Huey Fang , Power Emma , O'Halloran Robyn , Foster Abby 
Published: August 2018

AbstractBackgroundCommunication partners (CPs) find it challenging to communicate with people with communication disorders post‐stroke. Stroke communication partner training (CPT) can enhance CPs’ ability to support the communication and participation of people post‐stroke. While evidence for the efficacy of aphasia‐based CPT is strong, implementation in healthcare settings is unclear.AimsTo investigate Australian speech pathologists’ current stroke CPT practices, factors influencing the implementation of CPT and how reported practice compares with the research evidence.Methods & ProceduresSpeech pathologists in Australia who had worked with people post‐stroke were invited to complete a 99‐item online survey. The survey was informed by a comprehensive review of the literature review, the Template for Intervention Description and Replication (TIDieR) intervention taxonomy, and the theoretical domains framework. data were analyzed using descriptive statistics and content analysis.Outcomes & ResultsA total of 122 clinicians were surveyed. Most participants reported providing CPT to treat a range of post‐stroke communication disorders. While 98.3% reported training familiar CPs, only 66.1% reported training unfamiliar CPs. Current stroke CPT practice is characterized by one to two < 1 h sessions of informal face‐to‐face education and skills training. Only 13.3% and 10.0% of participants used evidence‐based published programmes with unfamiliar and familiar CPs respectively. The main barriers included the perceived lack of behavioural regulation, skills, reinforcement, beliefs about consequences, positive social influences and resources. The main facilitators included clinicians’ intentions to provide CPT, perception of CPT as part of their role and perceived compatibility of CPT with clinical practice.Conclusion & ImplicationsA significant evidence–practice gap exists. Research exploring the implementation of stroke CPT in healthcare settings, expanding evidence to support CPT for the range of post‐stroke communication disorders, developing freely accessible step‐by‐step CPT programmes that consider restrictions in current practice and providing explicit instructions of CPT best practice are warranted. A supportive workplace culture and freely accessible formal training opportunities are also needed.
Fee‐for‐Service Medicare‐Enrolled Elderly Veterans Are Increasingly Voting with Their Feet to Use More VA and Less Medicare, 2003–2014
Authors: Liu Chuan‐Fen , Batten Adam , Wong Edwin S. , Fihn Stephan D. , Hebert Paul L. 
Published: August 2018

ObjectiveTo examine the long‐term reliance on outpatient care at the population (i.e., system) level among fee‐for‐service Medicare‐enrolled elderly veterans in the Department of Veterans Affairs (VA) health care system and Medicare from 2003 to 2014.Data Sources/Study SettingWe analyzed a 5 percent random sample, stratified by facility, age, gender, and race, of Medicare‐enrolled veterans enrolled in a VA primary care panel using VA administrative data and Medicare claims.Study DesignWe performed a repeated cross‐sectional analysis over 48 quarters. VA reliance was defined at the system level as the proportion of total visits (VA + Medicare) that occurred in VA. We examined four visit types and seven high‐volume medical subspecialties. We applied direct standardization adjusting for age, gender, and race using the 2010 population distribution of Medicare‐enrolled veterans.Principal FindingsOver the 12‐year period, VA provided the vast majority of mental health care. Conversely, veterans received slightly more than half of their primary care and most of their specialty care, surgical care, and seven high‐volume medical subspecialties through Medicare. However, reliance on VA outpatient care steadily increased over time for all categories of care.ConclusionsDespite the controversies about VA access to care, Medicare‐enrolled veterans, who have a choice of using VA or Medicare providers, appear to increase their use of VA care prior to the Choice Act.
CD39 positive regulatory T cell frequency as a biomarker of treatment response to methotrexate in rheumatoid arthritis
Authors: Gupta Vikas , Katiyar Shobhita , Singh Ankita , Misra Ramnath , Aggarwal Amita 
Published: August 2018

AbstractAimNearly one‐third of patients with rheumatoid arthritis (RA) do not respond to Methotrexate (MTX), the first‐line therapy in RA. CD39, an ectonucleotidase highly expressed on regulatory T cells (Tregs), is responsible for production of adenosine, an important anti‐inflammatory mediator of MTX action. Higher expression of CD39 on Tregs improves their suppressive capacity. Therefore, we aimed to study the role of CD39+ Treg frequency as a biomarker for MTX treatment response in RA.MethodsPatients with active RA who were naive to disease‐modifying anti‐rheumatic drugs were enrolled. Frequencies of CD39+ Tregs (CD4+CD25+FoxP3+CD39+ cells) and CD4+CD25+CD39+ cells were determined by flow cytometry in peripheral blood before the start of therapy. After 4 months of MTX monotherapy, patients were classified into responders (European League Against Rheumatism [EULAR] good/moderate response) and non‐responders (EULAR no response). All samples were genotyped for single nucleotide polymorphisms (SNPs) rs11188513 and rs7071836 in the ENTPD1 (CD39) gene.ResultsAfter 4 months of MTX monotherapy, 54 patients were classified as responders and 16 as non‐responders. The baseline CD39+ Treg and CD4+CD25+CD39+ cell frequencies were significantly higher in the responder group as compared with the non‐responder group (P < 0.05 and P < 0.01, respectively). AA genotype at SNP rs7071836 was associated with poor response to MTX (P < 0.05; odds ratio = 5.67; 95% CI = 1.12–28.75).ConclusionHigher frequencies of CD39+ Tregs and CD4+CD25+CD39+ cells in the peripheral blood are associated with response to MTX in RA and hence, these could be considered as potential biomarkers for prediction of response to MTX treatment.
Methotrexate intoxication: Beyond the adverse events
Authors: Dalkilic Ediz , Coskun Belkıs Nihan , Yağız Burcu , Tufan Ayşe Nur , Ermurat Selime , Pehlivan Yavuz 
Published: August 2018

AbstractAimMethotrexate (MTX) is the first‐line disease‐modifying antirheumatic drug in rheumatoid arthritis (RA). However, this anchor may cause some side effects that may range from nausea to mortality. The clinical features of MTX toxicity are under‐researched. In this study, we aimed to find out the potential predisposing factors and outcomes of the MTX toxicity (n = 31).MethodsThe data were collected from 31 patients whose ages ranged from 25 to 81 years, who were suffering from immune‐mediated inflammatory diseases and major MTX‐related toxicity.ResultsOut of 31 patients, six (19.4%) used MTX every day, and 13 (41.9%) patients had renal insufficiency who were admitted to the hospital because of mucositis (90.3%) and fever (71%). While using MTX, 27 patients (87.1%) were discharged after the treatment and four patients (12.9%) died.ConclusionsAlthough MTX has high efficacy for the toxicity ratio, wrong use and dosage of MTX may be harmful to patients. Thus, patients should be informed about the proper use of MTX.
Genetic implications in the pathogenesis of systemic sclerosis
Authors: Rezaei Ramazan , Aslani Saeed , Dashti Navid , Jamshidi Ahmadreza , Gharibdoost Farhad , Mahmoudi Mahdi 
Published: August 2018

AbstractSystemic sclerosis (SSc) is a chronic autoimmune disease of the connective tissues of unknown etiology, characterized mainly by fibrosis of the skin, vascular abnormalities, and systemic involvement of other organs, such as gastrointestinal tract, kidneys, lungs, and heart. SSc has been associated with a complex etiology with the involvement of both environmental and genetic factors in the onset and outcome of the disease. Although several major histocompatibility complex (MHC) and non‐MHC genes have been associated with the disease risk, there are several questions to answer. This article's purpose was to provide an extensive overview of the identified genetic factors in the etiopathogenesis of SSc.
Targeted capture sequencing identifies novel genetic variations in Chinese patients with idiopathic inflammatory myopathies
Authors: Peng Qing‐Lin , Lin Jin‐Ming , Zhang Yong‐Biao , Zhang Xue‐Zhi , Wang Pan‐Pan , Wu Ting‐Ting , Yu Jun , Dong Xiao‐Qun , Gu Ming‐Liang , Wang Guo‐Chun 
Published: August 2018

AbstractObjectivesPrevious association studies have identified genetic variants in the human leukocyte antigen (HLA) complex as substantial risk factors for idiopathic inflammatory myopathies (IIMs). However, a great number of genes are located in the HLA region, and thus fine mapping is quite necessary.MethodsTargeted capture sequencing were performed on the whole HLA region in 42 IIM patients and 24 healthy controls. A microarray analysis was applied to analyze gene expression profiles in additional 20 newly diagnosed IIM and five healthy controls.ResultsThe HLA region was confirmed to be associated with IIMs in Chinese patients. By gene expression profiling and pathway analysis, several genes were identified as candidates for IIM risk factors, including HLA‐A, HLA‐B, HLA‐DRB5, HLA‐DRB1, HLA‐DQA1, HLA‐DQB1 and HLA‐DQB2. Interestingly, p.Y107V of the HLA‐DRB1 was predicted to be a potential causal non‐synonymous variation for IIMs that may affect the antigen‐binding groove of the HLA‐II molecule.ConclusionsOur data have revealed novel genetic variations in the HLA region of IIM patients and provide new insight into the pathogenesis and diagnosis of IIMs.
Pulmonary hypertension in Takayasu arteritis
Authors: Sari Alper , Sener Yusuf Z. , Firat Esra , Armagan Berkan , Erden Abdulsamet , Oksul Metin , Hekimsoy Vedat , Asil Serkan , Kilic Levent , Kiraz Sedat , Kaya Ergun B. , Tokgozoglu Lale , Akdogan Ali 
Published: August 2018

AbstractAimTo determine the frequency and define the causes of pulmonary hypertension (PH) in patients with Takayasu arteritis (TA).MethodSixty‐four TA patients were evaluated by transthoracic echocardiography (TTE). Having an estimated systolic pulmonary arterial pressure (sPAP) ≥40 mm Hg by echocardiography or if performed, mean PAP ≥25 mm Hg in right heart catheterization was defined as PH. Clinical, imaging and laboratory results of the TA patients were obtained from hospital files.ResultIn total, seven (10.9%) patients had PH. Four patients had PH due to left‐sided heart disease (group 2 PH), three patients due to pulmonary arterial involvement (PAI; group 4 PH) and one patient due to atrial septal defect (group 1 PH). In one patient, combination of PAI, aortic insufficiency and pulmonary venous return anomaly was present and he was considered to have both group 2 and group 4 PH. PAI was more frequent (42.9% vs 15.7%) in patients with PH but the difference was not statistically significant. The percentage of patients treated with cyclophosphamide and/or biologics was higher in the group with PH as compared to the group without PH (P = 0.015). One patient with group 4 PH had been on pulmonary arterial hypertension (PAH)‐specific agents for 8 years.ConclusionPulmonary hypertension is not infrequent in TA patients and all the potential causes of PH should be carefully evaluated. Patients with severe or treatment‐resistant disease are prone to have PH. PAH‐specific agents may be effective in patients with group 4 PH.
Elucidating the environmental risk factors for rheumatic diseases: An umbrella review of meta‐analyses
Authors: Belbasis Lazaros , Dosis Vasilios , Evangelou Evangelos 
Published: August 2018

AbstractAimsAlthough rheumatic diseases constitute a leading cause of disability, the environmental risk factors for these diseases are not clarified. In the present study, we aim to systematically appraise the epidemiological credibility of the environmental risk factors for rheumatic diseases.MethodsWe systematically searched PubMed to capture meta‐analyses of observational studies on environmental risk factors for the most prevalent rheumatic diseases. For each association, we estimated the summary effect size estimate, the 95% confidence and prediction intervals, and the I2 metric. We further examined the presence of small‐study effects and excess significance bias.ResultsOverall, we identified 30 eligible papers describing 42 associations. Thirty‐three associations were statistically significant at P < 0.05, whereas 13 of them were statistically significant at P < 1 × 10−6. Thirty‐two associations had large or very large between‐study heterogeneity. In 12 associations, evidence of small‐study effects and/or excess significance bias was found. Six risk factors (nine associations) presented convincing or highly suggestive evidence of association: smoking and pack‐years of smoking for rheumatoid arthritis; BMI (per 5 kg/m2 increase) for gout and hip osteoarthritis; alcohol consumption for gout; BMI (overweight vs lean, obese vs lean), knee injury and participation in heavy work for knee osteoarthritis.ConclusionOur umbrella review indicated that a narrow range of risk factors has been examined for rheumatic diseases. Current evidence strongly supports that smoking, obesity, alcohol consumption, knee injury, and work activities are associated with risk for at least one rheumatic disease.
Protective effects of 2,3,5,4‐tetrahydroxystilbene‐2‐o‐β‐D‐glucoside against osteoporosis: Current knowledge and proposed mechanisms
Authors: Zhang Jinkang , Li Songlin , Wei Linlan , Peng Ye , Zheng Ziyang , Xue Jing , Cao Yukun , Wang Bin , Du Junjie 
Published: August 2018

AbstractAimThe aim of this study was to explore the mechanism underlying the protective effects of 2,3,5,4‐tetrahydroxystilbene‐2‐o‐β‐D‐glucoside (TSG) against osteoporosis.MethodMC3T3‐E1 mouse osteoblast precursor cells were used to analyze the protective effects of TSG on osteoblast apoptosis and differential inhibition induced by oxidative stress to determine the gene expression of forkhead transcription factor FKHRL1 (FoxO3a), T cell factors (TCFs), and downstream genes. A mouse model was used to assess the protective effects of TSG on ovariectomy‐induced osteoporosis as well as on Cell Counting Kit‐8 (CCK) gene expression, including that of FoxO3a. The mechanism underlying the protective effects of TSG against osteoporosis was further explored using high‐throughput sequencing data.ResultsA CCK‐8 assay in MC3T3‐E1 cells and hematoxylin and eosin staining in mouse tissue indicated that cell viability and bone tissue development were inhibited by oxidative stress and ovariectomy and that TSG neutralized or attenuated this effect. The expression levels of FoxO3a, TCF, and downstream genes and the indices of oxidative stress were the same in MC3T3‐E1 cells and the bone tissues of the mouse model. Bioinformatics analysis indicated that the cardiac muscle contraction and chemokine signaling pathway were disturbed in MC3T3‐E1 cells treated with hydrogen peroxide. Gene ontology‐biological process analysis revealed the influence of TSG treatment.ConclusionOsteoporosis and cardiac diseases appear to share a common mechanism. In addition to Wnt/FoxO3a signaling, the immune system and the chemokine signaling pathway may contribute to the protective mechanism of TSG.
Microarray expression profile of long non‐coding RNAs in human lung adenocarcinoma
Authors: Yang Zhiyi , Li Hongli , Wang Zhaoyan , Yang Yuling , Niu Jie , Liu Yuanyuan , Sun Zhiliang , Yin Chonggao 
Published: August 2018

BackgroundLong non‐coding RNAs (lncRNAs) participate in many biological dynamics and play significant roles in gene regulation. LncRNA expression is altered in many cancers; however, the expressions and functions of lncRNA genes in lung adenocarcinoma (LAD) remain unknown.MethodsLncRNA and messenger RNA (mRNA) expression in LAD without lymphatic metastasis versus paired adjacent non‐tumor (ANT) lung tissues and LAD with versus without lymphatic metastasis were analyzed using Human LncRNA Arraystar V3.0. The expression levels of four downregulated and four upregulated lncRNAs were verified using quantitative real‐time PCR in cells and tissue specimens.ResultsIn this study, 949 lncRNAs and 681 mRNAs had differential expression in LAD without lymphatic metastasis compared to ANT lung tissues, while 2740 lncRNAs and 1714 mRNAs were differentially expressed in LAD with lymphatic metastasis compared to LAD without lymphatic metastasis. The expression patterns of selected lncRNAs (LINC00113, AC005009.1, ARHGAP22‐IT1, AC009411.1, SRGAP3‐AS2, EGFEM1P, FAM66E, and HLA‐F‐AS1) were consistent with microarray data. Differentially expressed mRNA genes were enriched in crucial Gene Ontology terms and pathways.ConclusionOur results revealed differentially expressed lncRNAs in LAD, suggesting lncRNAs may be potential indicators for LAD diagnosis and therapy.