bluuebunny/crossref_metadata_2025_split huggingface dataset:
Режисерські версії «Тригрошової опери»: до питання актуальності теорії епічного театру Бертольта Брехта в театрі ХХI століття
Authors: Миленька Галина 
Published: November 2024

Розглянуто три версії сценічного прочитання «Тригрошової опери» Бертольта Брехта, а саме виставу Е. Енгеля (Берлін,1928), Р. Вілсона (Берлін, 2007), Р. Норріса (Лондон, 2016). Мета дослідження – зіставити за допомогою порівняльного аналізу виставу в театрі Шиффбауердам, безпосередню участь у постановці якої брав Б. Брехт, та режисерські рішення на сцені Королівського національного театру і театру «Берлінер Ансамбль»; виявити межі інтерпретаційних можливостей сценічного прочитання п’єси «Тригрошова опера», у якій вперше реалізовано напрацювання Б. Брехта в галузі теорії епічного театру. Методологія дослідження. Для досягнення поставленої мети застосовано методологію театрознавчого аналізу, який передусім базується на культурно-історичному та системному підходах, методах теоретичного аналізу та синтезу, компаративістики й аналогії, абстрагування та конкретизації. Наукова новизна. Уперше здійснено аналіз вистав за п’єсою Б. Брехта «Тригрошова опера» на сцені європейського театру ХХІ століття та простежено вплив його теорії і практики на сучасне режисерське мистецтво. Висновки. Спираючись на вимоги Б. Брехта до сценічної реалізації «Тригрошової опери» та основні позиції його теорії епічного театру, виявлено, що не всі режисерські спроби вільної інтерпретації п’єси Б. Брехта стають вдалим режисерським досвідом, відкриттям нових смислів і повноцінним художнім явищем, з одного боку. З іншого – урахування базових формоутворювальних аспектів брехтівської драматургії навіть у найсміливіших режисерських інтерпретаціях, які спонукають до продукування неймовірних засобів сценічної виразності, здатні створити нову естетичну реальність та наблизити суть змісту п’єси до глядача ХХІ століття.
Віртуальна та доповнена реальність у сценічних практиках: комплексне дослідження технологічного досвіду
Authors: Совгира Тетяна , Кузнєцова Валерія , Шмегельська Юлія 
Published: November 2024

Мета дослідження – визначити потенціал використання технологій віртуальної та доповненої реальності в сценічному просторі для виявлення впливу імерсивних технологій на мистецький простір. У статті проаналізовано технологічні проблеми впровадження технологій віртуальної та доповненої реальностей у сценічному просторі та шляхи їх вирішення. Методологія дослідження являє собою поєднання кількох методів: аналітичного – для опрацювання літератури, систематизації джерел та виявлення ключових тенденцій; теоретико-концептуального – для аналізу понятійно-термінологічного апарату дослідження та виявлення специфіки впровадження VR- та AR-технологій у культурно-мистецьку практику; порівняльно-типологічного – для порівняння AR- та VR-технологій, огляду результатів попередніх досліджень і визначення загальних закономірностей; методу систематизації – для узагальнення отриманих результатів. Наукова новизна полягає у визначенні можливостей застосування технологій віртуальної та доповненої реальності, творчих методів для створення інтерактивного та захопливого досвіду з метою оптимізації досвіду практичного застосування в сценічному просторі. Висновки. Проникнення VR та AR у художнє вираження не позбавлене викликів. Потрібні дослідження для подолання апаратних обмежень, складної розробки програмного забезпечення та етичних питань. Доповнена реальність є сучасним інструментом дизайн-проєктування, що дає змогу оптимізувати різні етапи роботи в загальному процесі. Завдяки активному розвитку цифрових технологій можливості моделювання та візуалізації 3D-об’єктів постійно розширюються, технологія стає доступнішою широкому загалу. Автор наголошує на необхідності більш детального розгляду можливостей використання доповненої реальності безпосередньо в проєктній роботі дизайнера, оскільки моделювання в такому ракурсі дає змогу швидше ухвалювати рішення – розроблювати та оцінювати різні варіанти. Отже, технологія доповненої реальності має значні переваги перед віртуальною реальністю та має всі шанси на панування в просторі дизайн-проєктування інтер’єрів.
Effectiveness of a toothbrushing intervention utilizing puzzle-solving game assisted with visual aids among adolescents: A single-blind randomized controlled trial
Authors: Santhosh Varkey Nadakkavukaran , Shankkari Siva , Coutinho David , Ankola Anil V , Sankeshwari Roopali M , Hampiholi Vinuta , Varghese Anu Sara , Parimala Yuvarani Kandasamy 
Published: November 2024

BackgroundMaintaining good oral hygiene through effective toothbrushing is crucial for preventing dental issues in adolescents. Conventional oral health education (OHE) and video demonstration approach are passive means of OHE, that often fail to engage this age group. This study introduced an innovative approach to OHE by combining jigsaw puzzle and visual aids to improve oral health outcomes among adolescents.ObjectiveTo assess the effectiveness of Jigsaw Puzzle-assisted Visual Reinforcement (JPVR) technique on toothbrushing knowledge, practices, and clinical oral health parameters compared to conventional OHE and video demonstration among adolescents.Material and methodsThis single-blind randomized controlled trial involved 195 adolescents aged 12-15 years randomly allocated to three groups: conventional OHE (control), video demonstration and JPVR. Interventions were administered, and assessments were carried out at baseline, 1 month, and 3 months. Prior to the start of the study, the oral hygiene aids used were standardized. Outcomes were measured using a self-designed, validated closed-ended questionnaire to assess the toothbrushing knowledge and practices. This was followed by clinical examination carried out using gingival and plaque indices by a blinded examiner.ResultsAt baseline, groups had comparable knowledge, practices, and clinical parameters. At 3 months, the JPVR group demonstrated significantly higher knowledge, better practices, lower plaque, and reduced gingival scores compared to other groups.ConclusionsThe JPVR technique improved toothbrushing knowledge, practices, and clinical oral health parameters among adolescents. This approach fostered active learning and knowledge retention and is a cost-effective strategy for promoting positive oral health outcomes among children.
Las instituciones argentinas de educación superior, ¿impulsan la sostenibilidad?
Authors: Arias Valle María Belén , Marimon Frederic 
Published: November 2024

Este estudio aborda cómo las instituciones argentinas de educación superior integran la sostenibilidad en sus programas educativos, de modo alineado con la Agenda 2030 y la Ley 27621 de Educación Ambiental Integral. Se realizó un estudio cuantitativo descriptivo transversal que incluyó a 132 instituciones, y se evaluó su oferta educativa en sostenibilidad. Los resultados revelan que el 54 % de ellas incorpora al menos una modalidad de enseñanza relacionada con la sostenibilidad, entre las que destacan las áreas de gestión ambiental y energías renovables. Sin embargo, existe una notable disparidad entre las provincias, con Buenos Aires, Santa Fe y Mendoza liderando en la oferta educativa, mientras que otras regiones presentan una oferta limitada. Además, se observa una mayor prevalencia de programas de grado y maestría en comparación con cursos, especializaciones, diplomaturas y doctorados. Las instituciones públicas tienen una mayor participación en la enseñanza de sostenibilidad que las privadas. El estudio concluye que, aunque hay un compromiso significativo con la sostenibilidad, es necesario implementar políticas y estrategias para mejorar la equidad regional y diversificar la oferta educativa. Se recomienda desarrollar normativas, guías prácticas y programas de capacitación, así como fomentar la colaboración entre instituciones y asegurar financiamiento adecuado para apoyar estas iniciativas.
The Dual Role of Women in Employment in the Sinah Kasih Village Oil Palm Plantation
Authors: Putri Widisyah , Malik Rahman , Hidir Achmad 
Published: November 2024

Indonesia is the countries with the largest palm oil producer in the world. Oil palm plants are one of the plantation crops that produce vegetable oil, which has become Indonesia's main and superior agricultural commodity. In the division of labor on plantations, there is still an imbalance between men and women. Women spend a lot of time in the garden and have to divide their time into housework. The dual roles experienced by women are very influential in the division of labor. This study presents the division of labor according to Harvard's division of labor. Women also work like men in oil palm plantations and women also play the role of housewives who take care of their husbands, children, and home. Meanwhile, men only work in industry, do not want to contribute to taking care of children and other household work, women do not get the same salary as men.
Analisis Determinan Faktor pada Earning Per Share Perusahaan
Authors: Asteria Beta , Riauwanto Selamet 
Published: November 2024

Research aimed to analyze the effect of profitability and solvency to earnings per share. EPS describes the firm’s performance. Whether the firm’s performance is good or not, one of which is measured by its ability to generate profit per share. Also the presence of research gaps from previous research. This makes this research interesting and urgent to do. This research is used purposive sampling method. The samples criteria are included in the LQ45 Index, have positive EPS, have positive profitability and have complete data needed in this research. Research data were analyzed through the Linear Regression program. Regression analysis is carried out by conducting the t test and F test. T test is carried out to analyze the effect of each independent variable on the dependent variable and F test is carried out to analyze the effect of the independent variables simultaneously on the dependent variable. Based on the t test, the results show that Return on Equity or profitability at a significance of 0.000 <0.05 and the Solvency variable at a significance of 0.001 <0.05 proves to have a significant effect on Earnings Per Share (EPS). Based on the F test, it shows the results of profitability and solvency have simultaneous significant effect on Earnings Per Share (EPS) at a significance of 0.001 <0.05.
Pengaruh Green Finance terhadap Keputusan Investasi pada Sektor Energi Baru Terbarukan di Bursa Efek Indonesia
Authors: Sari Amilia Paramita 
Published: November 2024

The present study investigates the impact of green financing rules on investment decisions made by investors in the Indonesia Stock Exchange-listed New and Renewable Energy sector. The move toward cleaner energy is being fueled in large part by green finance due to the growing focus on sustainability and its effects on the environment. Using a census approach to gather data from the financial statements of firms in the New and Renewable Energy Sector, simple linear regression analysis is the research method employed, along with the green finance policies that are relevant in Indonesia. The study's findings demonstrate that green financing has a major and favorable impact on this industry's investment choices. Additionally, businesses that employ green financing are more likely to do financially well, which draws in additional investors. This finding highlights the significance of putting more targeted measures into place to support green finance investment in order to meet sustainability and economic growth objectives in the New and Renewable Energy Sector, which has important ramifications for investors and policymakers.
Single-cell sequencing unveils mitophagy-related prognostic model for triple-negative breast cancer
Authors: Ding Peikai , Pei Shengbin , Qu Zheng , Yang Yazhe , Liu Qiang , Kong Xiangyi , Wang Zhongzhao , Wang Jing , Fang Yi 
Published: November 2024

BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, leading to limited treatment options and poor prognosis. Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood.MethodsThis study utilized single-cell RNA sequencing data from the TCGA and GEO databases to identify mitophagy-related genes (MRGs) associated with TNBC. A prognostic model was developed using univariate Cox analysis and LASSO regression. The model was validated across multiple independent cohorts, and correlations between MRG expression, immune infiltration, and drug sensitivity were explored.ResultsNine key MRGs were identified and used to stratify TNBC patients into high-risk and low-risk groups, with the high-risk group showing significantly worse survival outcomes. The model demonstrated strong predictive accuracy across various datasets. Additionally, the study revealed a correlation between higher MRG expression levels and increased immune cell infiltration, as well as potential responsiveness to specific chemotherapeutic agents.ConclusionThe mitophagy-related prognostic model offers a novel method for predicting outcomes in TNBC patients and highlights the role of mitophagy in influencing the tumor microenvironment, with potential applications in personalized treatment strategies.
Common molecular basis for MASH and hepatitis C revealed via systems biology approach
Authors: Cheng Yongwei , Song Zihao , Liu Ye , Xu Xichao , Zhang Dali , Zou Yigui , Liu Liang , Zeng Yinzhen , Li Wenwen , Bai Daming , Dai Dongling 
Published: November 2024

BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is characterized by liver inflammation and damage caused by a buildup of fat in the liver. Hepatitis C, caused by hepatitis C virus (HCV), is a disease that can lead to liver cirrhosis, liver cancer, and liver failure. MASH and hepatitis C are the common causes of liver cirrhosis and hepatocellular carcinoma. Several studies have shown that hepatic steatosis is also a common histological feature of liver in HCV infected patients. However, the common molecular basis for MASH and hepatitis C remains poorly understood.MethodsFirstly, differentially expressed genes (DEGs) for MASH and hepatitis C were extracted from the GSE89632, GSE164760 and GSE14323 datasets. Subsequently, the common DEGs shared among these datasets were determined using the Venn diagram. Next, a protein-protein interaction (PPI) network was constructed based on the common DEGs and the hub genes were extracted. Then, gene ontology (GO) and pathway analysis of the common DEGs were performed. Furthermore, transcription factors (TFs) and miRNAs regulatory networks were constructed, and drug candidates were identified. After the MASH and hepatitis C cell model was treated with predicted drug, the expression levels of the signature genes were measured by qRT-PCR and ELISA.Results866 common DEGs were identified in MASH and hepatitis C. The GO analysis showed that the most significantly enriched biological process of the DEGs was the positive regulation of cytokine production. 10 hub genes, including STAT1, CCL2, ITGAM, PTPRC, CXCL9, IL15, SELL, VCAM1, TLR4 and CCL5, were selected from the PPI network. By constructing the TF-gene and miRNA-gene network, most prominent TFs and miRNAs were screened out. Potential drugs screening shows that Budesonide and Dinoprostone may benefit patients, and cellular experiments showed that Budesonide effectively inhibited the expression of genes related to glycolipid metabolism, fibrosis, and inflammatory factors.ConclusionWe extracted 10 hub genes between MASH and hepatitis C, and performed a series of analyses on the genes. Molecular docking and in vitro studies have revealed that Budesonide can effectively suppress the progression of MASH and hepatitis C. This study can provide novel insights into the potential drug targets and biomarkers for MASH and hepatitis C.
Wuwei Kushen Changrong capsule alleviates DSS-induced colitis in mice via inhibition of NLRP3 inflammasome and STAT3 pathway
Authors: Chen Mingjun , Feng Yang , Luo Dan , Zhang Chen , Zhou Jing , Dai Hengheng , Lin Mingxiong , Tong ZhanQi 
Published: November 2024

PurposeWuwei Kushen Changrong capsule (Composite Sophora Colon-soluble Capsule, CSCC) is a Chinese patent medicine developed to treat ulcerative colitis. Studies highlight CSCC potential efficacy for ulcerative colitis (UC) but unclear mechanism limits its widely treatment for patients. We aimed to investigate the anti-colitis efficacy of CSCC and explore the mechanism by which GPR43 inhibits the NLRP3/STAT3 signaling pathway, thereby mediating the protective effects of CSCC on the intestinal barrier.MethodsThe protective effects of CSCC were evaluated in a murine ulcerative colitis model induced by 3% DSS. Assessments included body weight, Disease Activity Index (DAI) score, colon length, and histopathological score. Colon tissue, cell function, and immune-inflammatory status were evaluated using immunohistochemistry, immunofluorescence, ELISA, and real-time fluorescence quantitative PCR (RT-PCR). Protein expression levels of relevant pathways and receptors were measured using Western blot. All experiments were repeated.ResultsCSCC protected mice from DSS-induced colitis by upregulating Gpr43, promoting the expression of ZO-1 and Occludin tight junction proteins. Mechanistically, CSCC inhibits the MEK4/JNK1/STAT3 activation pathway, consequently suppressing the STAT3/NLRP3/IL-1β pathway and inhibiting the production of inflammatory factors such as IL-17A.ConclusionThe mechanisms through which CSCC protects against DSS-induced colitis may include upregulating Gpr43, inhibiting the STAT3/NLRP3 pathway, and suppressing inflammation factors like IL-17A. These findings highlight the mechanisms underlying CSCC’s anti-colitis effects and suggest its potential as a therapeutic candidate for managing the progression of UC.
The reproductive strategy of a typical distylous Ophiorrhiza alatiflora (Rubiaceae), in fragmented habitat
Authors: Li Yu , Yao Ren-Xiu , Xu Bo , Liu Yun-Jing , Li Bai-Zhu , Tang Ming , Yi Yin , Wen Zhi-Rui , Wang Xiao-Yue , Tang Xiao-Xin 
Published: November 2024

IntroductionHeterostyly is a genetically controlled style polymorphism, that plays an important role in promoting outcrossing and improving reproductive fitness. Although distyly is often studied in plants of the Rubiaceae family, little attention has been paid to the reproductive strategies of distylous species in fragmented habitats. Here, We report for the first time the growth of Ophiorrhiza alatiflora, a type distylous species, in karst areas and evaluate its reciprocity between long styled morph and short one. We analyze the two distyly morph differences in the ancillary polymorphic of flowers and explore their reproductive strategy in fragmented habitats.MethodsIn this study, we measured the floral characteristics of different morphs and performed differential secondary metabolite analysis on different morphs and tissue organs; Different pollination treatments were carried out to observe the fruit set, pollen germination, and pollen tube elongation of O. alatiflora.Results and discussionOur research indicates that O. alatiflora is a typical distylous plant for the distyly has high reciprocity. Both morphs exhibit the highest fruit set of intermorph outcrossing; The pollen germination and pollen tube elongation experiments have also demonstrated that the affinity of pollen from intermorph outcrossing is highest, regardless of whether it is the long or short morph as the maternal parent; Meanwhile, O. alatiflora is an incompletely self-incompatible plant that exhibits a certain degree of self-pollination and intramorph outcrossing, which may be one of the important means to ensure sustainable reproduction in severely disturbed habitats. In the ancillary polymorphic of flowers, L-morphs flowers produce more pollen, and S-morph flowers produce more ovules to improve their male-female fitness and compensate for the asymmetry of pollen flow; Compared with S-morphs, L-morphs contain significantly higher levels of several kinds of terpenoids. S-morphs produce more flavonoids than L-morphs. The differences in secondary metabolites between L-morphs and S-morphs are mainly reflected in the different nutritional organs (including stems and leaves). Overall, our work has revealed the unique reproductive strategy of O. alatiflora in fragmented habitats based on the characteristics of distyly, verifying the hypothesis that the distyly of O. alatiflora promotes outcrossing and avoids male-female interference, improving male-female fitness and this is the first time in the Ophiorrhiza genus.
The mediating role of resilience in the relationship between meaning in life and attitude toward death among ICU nurses: a cross-sectional study
Authors: Wang Lifang , Li Sisi , Liu Xiaorong , Li Rong , Li Ran 
Published: November 2024

BackgroundThe majority of elderly individuals prefer to spend their final days in the Intensive Care Unit (ICU). ICU nurses are key providers in hospice care, and their attitudes toward death influence the quality of end-of-life nursing. Positive psychology emphasizes promoting positive attitudes toward death. A sense of meaning in life and resilience are critical aspects of positive psychology, which are essential for shaping ICU nurses’ attitudes toward death.ObjectiveThis study aims to investigate whether a sense of meaning in life indirectly affects attitudes toward death through the mediation of resilience.MethodA total of 212 ICU nurses from four tertiary general hospitals in Guangdong and Fujian provinces, China, participated in this study. They completed an online questionnaire, including the Death Attitude Profile-Revised, the Connor-Davidson Resilience Scale, and the China Meaning in Life Questionnaire for ICU nurses.ResultsICU nurses scored highest in natural acceptance (3.26 ± 0.53), followed by escaping acceptance (2.54 ± 0.59), and fear of death (2.53 ± 0.78). The proposed model fit the data well. Both the presence of meaning and the search for meaning were positive predictors of resilience (β = 0.313, p &lt; 0.05; β = 0.256, p &lt; 0.05). Resilience, the presence of meaning, and the search for meaning positively predicted natural acceptance (β = 0.299, p &lt; 0.05; β = 0.294, p &lt; 0.05; β = 0.177, p &lt; 0.05). Conversely, these factors negatively predicted fear of death (β = −0.179, p &lt; 0.05; β = −0.251, p &lt; 0.05; β = −0.192, p &lt; 0.05) and escaping acceptance (β = −0.208, p &lt; 0.05; β = −0.208, p &lt; 0.05; β = −0.219, p &lt; 0.05). Mediation analysis indicated that resilience had a partial mediating role.ConclusionThe presence of meaning and the search for meaning influence attitudes toward death, with resilience serving as a partial mediator. It is recommended that nursing administrators consider ICU nurses’ attitudes toward death and emphasize the importance of meaning in life and resilience in death education. This approach can help protect the psychological well-being of ICU nurses, promote a deeper understanding of life’s meaning, and develop a scientific perspective on death. Such measures are crucial for providing better humanistic care and psychological comfort to terminally ill patients and their families, thereby improving the quality of end-of-life care.