bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathology of inflammatory diseases of the nervous system: Human disease versus animal models
Authors: Lassmann Hans 
Published: October 2019

AbstractNumerous recent studies have been performed to elucidate the function of microglia, macrophages, and astrocytes in inflammatory diseases of the central nervous system. Regarding myeloid cells a core pattern of activation has been identified, starting with the activation of resident homeostatic microglia followed by recruitment of blood borne myeloid cells. An initial state of proinflammatory activation is at later stages followed by a shift toward an‐anti‐inflammatory and repair promoting phenotype. Although this core pattern is similar between experimental models and inflammatory conditions in the human brain, there are important differences. Even in the normal human brain a preactivated microglia phenotype is evident, and there are disease specific and lesion stage specific differences in the contribution between resident and recruited myeloid cells and their lesion state specific activation profiles. Reasons for these findings reside in species related differences and in differential exposure to different environmental cues. Most importantly, however, experimental rodent studies on brain inflammation are mainly focused on autoimmune encephalomyelitis, while there is a very broad spectrum of human inflammatory diseases of the central nervous system, triggered and propagated by a variety of different immune mechanisms.
Association of GWAS‐supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population
Authors: Liang Si‐Qiao , Deng Jing‐Min , Wei Xuan , Chen Zhang‐Rong , Yang Mei‐Ling , Qin Hua‐jiao , Zhang Jian‐quan , He Zhi‐yi 
Published: October 2019

AbstractBackgroundAsthma is a complicated and polygenic inheritance disease, and its prevalence increases worldwide. Recent genome‐wide association studies (GWASs) identified a significant association of single nucleotide polymorphism with asthma in the Japanese population. This study aimed to examine the association of GWAS‐supported noncoding area loci, namely rs404860, rs3117098, and rs7775228, with asthma in Chinese Zhuang population.MethodsA case‐control study involving 223 individuals, comprising 123 patients with asthma and 100 healthy controls, was conducted. Genotypes were determined by polymerase chain reaction (PCR)/ligase detection reaction assay. The association between gene polymorphisms and asthma risk was calculated by logistic regression analysis using different genetic models through comparisons of alleles (A vs a), homozygote genotypes (AA vs aa), heterozygote genotypes (Aa vs aa), dominant models (AA+Aa vs aa), and recessive models (AA vs. Aa+aa).ResultsThe distribution of the genotype frequency of rs3117098 was statistically different between the case and control groups. For rs3117098, significant associations were observed through comparisons of alleles (OR: 1.832, 95% CI: 1.048‐3.204, P = .034) and dominant models (OR: 2.065, 95% CI: 1.001‐4.260, P = .050). The statistical analysis showed no significant difference for loci rs404860 and rs7775228 between patients with asthma and controls.Conclusionrs3117098 may be the risk factor for asthma in Chinese Zhuang population.
Extensor hallucis longus tendon and soft‐tissue reconstruction with palmaris longus tendon included in a radial forearm free flap: A case report
Authors: Lucattelli Elena , Bastoni Stefano , Bartoli Maria S. , Menichini Giulio , Innocenti Marco , Daolio Primo A. 
Published: October 2019

AbstractReconstruction of foot structures is challenging because of the need to restore both anatomy and function. Extensor hallucis longus (EHL) excision without reconstruction could result in a flexion deformity of the toe at the interphalangeal joint. In this report, we present a case of the use of a palmaris longus tendon included in a fasciocutaneous radial forearm free flap to reconstruct EHL tendon and soft tissues of the distal foot dorsum. A 41‐year‐old woman presented with a recurrence of myxoinflammatory fibroblastic sarcoma on the medial part of the left foot dorsum. The EHL tendon was sacrificed, leaving a soft‐tissue defect of 14 × 5 cm and 14‐cm tendon gap. A 14 × 5 cm radial forearm flap with a 16‐cm section of palmaris longus tendon was harvested from the left forearm. Radial artery and its comitant vein were anastomosed with dorsalis pedis artery and vein. EHL tendon repair was performed from the composite mass to the proximal and distal stumps. No complication in the postoperative period occurred. At latest follow‐up, 12 months postoperatively, the patient showed a normal joint function and was satisfied with the treatment. Palmaris longus tendon included in a radial forearm free flap could be recommended for combined soft tissue and tendon defects, particularly on the foot dorsum.
Fabrication of microfiltration membranes from polyisobutylene/polymethylpentene blends
Authors: Ignatenko Viktoria Y , Anokhina Tatyana S , Ilyin Sergey O , Kostyuk Anna V , Bakhtin Danila S , Antonov Sergey V , Volkov Alexey V 
Published: October 2019

AbstractAn approach for fabrication of microfiltration membranes by solvent extraction of one of the immiscible components from a polymer blend was developed. Poly(4‐methyl‐1‐pentene) (PMP) was the membrane material, and poly(isobutylene) (PIB) was the extractable component. The PIB content varied in the wide range 0–45 wt%, and all blends could be melted and processed at a temperature of 240 °C. A rheological study demonstrated a pronounced non‐Newtonian behavior of PMP/PIB blends and their very low viscosity due to interlayer slip. With a PMP content of 55 and 60 wt%, it was possible to fabricate microfiltration membranes with a water permeability of 31 and 3.7 m3 m−2 h–1 bar–1, respectively. The microfiltration membranes based on both compositions demonstrated good rejection performance at the level of 93%–98% for submicron particles of phthalocyanine dye with a size of 240 nm. These results indicate that the PMP/PIB system can be utilized for fabrication of filtration membranes by means of 3D printing followed by solvent extraction. © 2019 Society of Chemical Industry
Preconception resveratrol intake against infertility: Friend or foe?
Authors: Ochiai Asako , Kuroda Keiji 
Published: October 2019

AbstractBackgroundResveratrol is an antiaging, antioxidant, anti‐inflammatory, and insulin‐sensitizing natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian function, polycystic ovary syndrome (PCOS), or endometriosis. However, only one clinical trial in women undergoing in vitro fertilization (IVF) cycles using resveratrol has ever been reported. This review focuses on the potential therapeutic effects of resveratrol on pregnancy and on its advantages and disadvantages in pregnancy outcomes during infertility treatment.MethodsWe performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium.ResultsResveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2‐RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual‐related genes.ConclusionsResveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti‐deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.
A new tusked cistecephalid dicynodont (Therapsida, Anomodontia) from the upper Permian upper Madumabisa Mudstone Formation, Luangwa Basin, Zambia
Authors: Angielczyk Kenneth D. , Benoit Julien , Rubidge Bruce S. 
Published: October 2019

AbstractCistecephalids are among the most distinctive Permian dicynodonts because of their highly derived skulls and postcrania, which indicate a fossorial ecology. Four cistecephalid species have been described from India, South Africa, and Tanzania; a fifth putative species has been reported from the Luangwa Basin of Zambia but never formally described. Here we present a detailed description of the Luangwa Basin cistecephalid, which we nameKembawacela kitchingigen. et. sp. nov. The most obvious diagnostic character ofK. kitchingiis the presence of caniniform tusks in most specimens. Other important characters include a pineal foramen located at the posterior end of the skull roof; an interparietal that has a pair of anterior processes that extend onto the dorsal surface of the skull, flanking the pineal foramen (but otherwise is restricted to the occipital surface); an undivided nuchal crest; and a trough on the ventral surface of the mid‐ventral vomerine plate. Phylogenetic analysis reconstructsKembawacelaas a basal cistecephalid and confirms that Cistecephalidae is a well‐supported clade. However, relationships within the clade received low branch support. Increased knowledge of cistecephalid diversity shows that they vary in functionally relevant characters, such as degree of inflation of the bony vestibule and the morphology of the scapula and humerus, indicating the need for a more nuanced approach to the relationship between form, function and ecology in the clade. The highly allopatric distribution of cistecephalid species suggests that they experienced strong interspecific competition for limited resources and had limited dispersal ability, similar to extant subterranean mammals.
Bulk-Boundary Correspondence for Disordered Free-Fermion Topological Phases
Authors: Alldridge Alexander , Max Christopher , Zirnbauer Martin R. 
Published: October 2019

Abstract
Guided by the many-particle quantum theory of interacting systems, we develop a uniform classification scheme for topological phases of disordered gapped free fermions, encompassing all symmetry classes of the Tenfold Way. We apply this scheme to give a mathematically rigorous proof of bulk-boundary correspondence. To that end, we construct real C$$^*$$

∗

-algebras harbouring the bulk and boundary data of disordered free-fermion ground states. These we connect by a natural bulk-to-boundary short exact sequence, realising the bulk system as a quotient of the half-space theory modulo boundary contributions. To every ground state, we attach two classes in different pictures of real operator $$K$$
K
-theory (or $$KR$$

KR

-theory): a bulk class, using Van Daele’s picture, along with a boundary class, using Kasparov’s Fredholm picture. We then show that the connecting map for the bulk-to-boundary sequence maps these $$KR$$

KR

-theory classes to each other. This implies bulk-boundary correspondence, in the presence of disorder, for both the “strong” and the “weak” invariants.
Thermoelectric properties of CeNi2Al3 compound: an experimental and theoretical study
Authors: Szajek A. , Kowalczyk A. 
Published: October 2019

Abstract
We present thermoelectric properties of the CeNi2Al3 compound in the temperature range from 4 to 300 K. The electrical resistance (ρ) exhibits a metallic-like character reaching approximately 50 μΩ cm at room temperature. The temperature dependence of the Seebeck coefficient (S) is typical for mixed valence compounds having positive values with a broad maximum (~ 46 μV/K) over a wide temperature range from 200 to 300 K. The thermal conductivity (κ) value reaches 15 W/(m K) at T = 300 K. The power factor (PF = S2/ρ) at 150 K is high (~ 70 μW/cm K2), larger than for conventional thermoelectric materials based on Bi2Te3. The dimensionless figure of merit (ZT) has a broad maximum over a wide temperature range, which reaches the value of 0.1 around 220 K. The experimental results are supported by calculations within the density functional theory (DFT) performed on the basis of the full-potential local-orbital minimum-basis scheme (FPLO). The coherent potential approximation (CPA) is used to simulate the chemical disorder. The calculations are focused on the site preference of Ni and Al atoms. Investigations of the energetic stability have shown that in CeNi2Al3 the aluminum atoms prefer the 3g sites and the nickel ones the 2c sites.
Characterisation and laser performance of a Yb:LuAG double-clad planar waveguide grown by pulsed laser deposition
Authors: Kurilchik Sergey V. , Prentice Jake J. , Eason Robert W. , Mackenzie Jacob I. 
Published: October 2019

Abstract
We report on the fabrication of a crystalline multi-layer lutetium aluminium garnet planar waveguide, with a ytterbium-doped core, via hetero-epitaxial pulsed laser deposition on an undoped yttrium aluminium garnet substrate. Physical and optical characterization of the device revealed good crystallinity of the grown films and mode propagation investigations confirmed waveguiding properties. The measured fluorescence lifetime and calculated absorption and stimulated emission cross section spectra are found to be comparable with those reported for Yb:LuAG crystals grown by traditional methods. When end-pumped by a diode-laser bar, the crystalline double-clad Yb:LuAG planar waveguide lased using a quasi-monolithic cavity configuration. An output power of > 3 W with a 20% slope efficiency was obtained, limited by a waveguide propagation loss of 1.2 dB cm−1. This first demonstration of a multi-layer LuAG double-clad planar waveguide laser shows great potential for realising compact high-power waveguide lasers and amplifiers.
A study on the effects and visibility of low-order aberrations on laser beams with orbital angular momentum
Authors: Ohland Jonas B. , Eisenbarth Udo , Roth Markus , Bagnoud Vincent 
Published: October 2019

Abstract
Laguerre–Gaussian-like laser beams have been proposed for driving experiments with high-intensity lasers. They carry orbital angular momentum and exhibit a ring-shaped intensity distribution in the far field which make them particularly attractive for various applications. We show experimentally and numerically that this donut-like shape is extremely sensitive to off-axis wavefront deformations. To support our claim, we generate a Laguerre–Gaussian-like laser beam and apply a selection of common low-order wavefront aberrations. We investigate the visibility of those wavefront deformations in the far field. Under use of established tolerance criteria, we determine the thresholds for the applied aberration and compare the findings with simulations for verification.
111In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis
Authors: Fujiwara Kentaro , Tsuji Atsushi B. , Sudo Hitomi , Sugyo Aya , Akiba Hiroki , Iwanari Hiroko , Kusano-Arai Osamu , Tsumoto Kouhei , Momose Toshimitsu , Hamakubo Takao , Higashi Tatsuya 
Published: October 2019

Abstract

Objective
Cadherin-17 (CDH17) is a transmembrane protein that mediates cell–cell adhesion and is frequently expressed in adenocarcinomas, including gastric cancer. CDH17 may be an effective diagnostic marker for the staging of gastric cancer. Here, we developed an 111In-labeled anti-CDH17 monoclonal antibody (Mab) as an imaging tracer and performed biodistribution and single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging studies using mice with CDH17-positive gastric cancer xenografts. CDH17 expression in gastric cancer specimens was also analyzed.

Methods
The cross-reactivity and affinity of our anti-CDH17 Mab D2101 was evaluated by surface plasmon resonance analysis and cell enzyme-linked immunosorbent assay, respectively. Biodistribution and SPECT/CT studies of 111In-labeled D2101 (111In-D2101) were performed. CDH17 expression in gastric cancer specimens was evaluated by immunohistochemistry.

Results
Surface plasmon resonance analysis revealed that D2101 specifically recognizes human CDH17, but not murine CDH17. The affinity of D2101 slightly decreased as a result of the radiolabeling procedures. The biodistribution study revealed high uptake of 111In-D2101 in tumors (maximum, 39.2 ± 9.5% ID/g at 96 h postinjection), but low uptake in normal organs, including the stomach. Temporal SPECT/CT imaging with 111In-D2101 visualized tumors with a high degree of tumor-to-nontumor contrast. Immunohistochemical analysis revealed that, compared with HER2, which is a potential marker of N-stage, CDH17 had a higher frequency of positivity in specimens of primary and metastatic gastric cancer.

Conclusion
Our 111In-anti-CDH17 Mab D2101 depicted CDH17-positive gastric cancer xenografts in vivo and has the potential to be an imaging probe for the diagnosis of primary lesions and lymph-node metastasis in gastric cancer.
Manual on the proper use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials
Authors: Hosono Makoto , Ikebuchi Hideharu , Kinuya Seigo , Yanagida Sachiko , Nakamura Yoshihide , Yamada Takahiro , Sakaguchi Kenta , Sugano Hiroyasu , Kojima Kiyotaka , Hatazawa Jun 
Published: October 2019

Abstract
We present the guideline for use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine. Treatment using yttrium-90-labeled anti-P-cadherin antibody injection in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown here are considered internationally useful as well. Only the original Japanese version is the formal document.
Comparative effectiveness of busulfan/cyclophosphamide versus busulfan/fludarabine myeloablative conditioning for allogeneic hematopoietic cell transplantation in acute myeloid leukemia and myelodysplastic syndrome
Authors: Patel Sagar S. , Rybicki Lisa , Pohlman Brad , Bolwell Brian , Gerds Aaron T. , Hamilton Betty K. , Hanna Rabi , Kalaycio Matt , Majhail Navneet S. , Sobecks Ronald 
Published: October 2019

Objective/Background:
Busulfan/cyclophosphamide (Bu/Cy) and busulfan/fludarabine (Bu/Flu) are both standard myeloablative conditioning (MAC) regimens for allogeneic hematopoietic cell transplantation (alloHCT). We compared the effectiveness of these regimens with a focus on quality of life (QOL).

Methods:
This was a single center, retrospective analysis of adult acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients who underwent a first T-cell replete HLA-8/8 matched related or unrelated donor alloHCT. Patients received a myeloablative regimen of either parenteral Bu/Cy or Bu/Flu. Outcomes assessed included infections, graft-versus-host-disease (GVHD), relapse, relapse mortality (RM), relapse-free survival (RFS), nonrelapse mortality (NRM), overall survival (OS), and QOL.

Results:
From 2008 to 2017, 126 AML and 84 MDS adult patients age ≥18 years were identified meeting inclusion criteria. In terms of QOL, there were no significant differences between Bu/Cy and Bu/Flu cohorts in the Functional Assessment of Cancer Therapy-Bone Marrow Transplant Scale (FACT-BMT) scores or mucositis severity for either AML or MDS patients. Amongst AML patients, those receiving Bu/Flu had more rapid neutrophil and platelet recovery and a shorter length of hospital stay (LOS); there were no differences in the other posttransplant outcomes. Similarly, amongst MDS patients, those receiving Bu/Flu had more rapid platelet recovery and a shorter LOS as well as more CMV infections, but less NRM and no differences in other outcomes.

Conclusion:
We confirmed that myeloablative Bu/Flu conditioning has comparable clinical and QOL outcomes to Bu/Cy.
Can Reconnection be Triggered as a Solar Wind Directional Discontinuity Crosses the Bow Shock? A Case of Asymmetric Reconnection
Authors: Hamrin M. , Gunell H. , Goncharov O. , De Spiegeleer A. , Fuselier S. , Mukherjee J. , Vaivads A. , Pitkänen T. , Torbert R. B. , Giles B. 
Published: October 2019

AbstractHere we present some unique observations of reconnection at a quasi‐perpendicular bow shock as an interplanetary directional discontinuity (DD) is crossing it simultaneously with the Magnetospheric Multiscale (MMS) mission. There are no burst data, but available data show indications of ongoing reconnection at the shock southward of MMS: a bifurcated current sheet with signatures of Hall magnetic and electric fields, normal magnetic fields indicating a magnetic connection between the two reconnecting regions, field‐aligned currents and electric fields, E·J>0 indicating a conversion of magnetic to kinetic energy, and subspin resolution ion energy‐time spectrograms indicating ions being accelerated away from the X‐line. The DD is also observed by four upstream spacecraft (ACE, WIND, Geotail, and ARTEMIS P1) and one downstream in the magnetosheath (Cluster 4), but none of them resolve signatures of ongoing reconnection. We therefore suggest that reconnection was temporarily triggered as the DD was compressed by the shock. Reconnection at the bow shock is inevitably asymmetric with both the density and magnetic field strength being higher on one side of the X‐line (magnetosheath side) than on the other side where the plasma flow also is supersonic (solar wind side). This is different from the asymmetry exhibited at the more commonly studied case of asymmetric reconnection at the magnetopause. Asymmetric reconnection of the bow shock type has never been studied before, and the data discussed here present some first indications of the properties of the reconnection region for this type of reconnection.
Introduction of Water‐Vapor Broadening Parameters and Their Temperature‐Dependent Exponents Into the HITRAN Database: Part I—CO2, N2O, CO, CH4, O2, NH3, and H2S
Authors: Tan Y. , Kochanov R. V. , Rothman L. S. , Gordon I. E. 
Published: October 2019

AbstractThe amount of water vapor in the terrestrial atmosphere is highly variable both spatially and temporally. In the tropics it sometimes constitutes 4–5% of the atmosphere. At the same time collisional broadening of spectral lines by water vapor is much larger than that by nitrogen and oxygen. Therefore, in order to accurately characterize and model spectra of the atmospheres with significant amounts of water vapor, the line‐shape parameters for spectral lines broadened by water vapor are required. In this work, the pressure‐broadening parameters (and their temperature‐dependent exponents) due to the pressure of water vapor for spectral lines of CO2, N2O, CO, CH4, O2, NH3, and H2S from both experimental and theoretical studies were collected and carefully reviewed. A set of semiempirical models based on these collected data was proposed and then used to estimate water broadening and its temperature dependence for all transitions of selected molecules in the HITRAN2016 database.