bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular docking, drug-likeness, and ADMET study of 1-benzyl-3-benzoylurea and its analogs against VEGFR-2
Authors: Suhud F , Tjahjono D H , Yuniarta T A , Putra G S , Setiawan J 
Published: July 2019

Abstract

In silico study was performed to predict the possibility of 1-benzyl-3-benzoylurea and 22 analogs as anticancer drug candidates, via VEGFR2 inhibition. Molecular docking studies against VEGFR2 receptor revealed that all of designed compounds have better score than the lead compound, of which three analogs (p-nitro, p-methoxy, and p-ethyl) were considered optimal among other compounds (< -90 kcal mol−1). However, this result was not comparable to lenvatinib, which acts as native ligand of the receptor (-118.62 kcal mol−1). Docking poses analysis showed that 1-benzyl-3-benzoylurea analogs failed to completely occupy VEGFR2 binding site. Therefore, it is argued that this has caused the non-optimal docking score of designed compounds. Furthermore, these compounds passed five different drug-likeness criteria successfully and were predicted to be orally bioavailable in rat. Ultimately, most of the analogs were predicted to have good ADMET characteristics, notably in terms of GI absorption and the absence of P-gp interaction, and low toxicity in rat. This study can be used as a starting point to validate this model by synthesis, in vitro and in vivo assay to validate the activity of 1-benzyl-3-benzoylurea and its analogs as potential anticancer candidate.
Coffee reduced the production of neutrophil superoxide radical in vitro
Authors: Susilawati I D A , Safaatin A , Burlakovs J 
Published: July 2019

Abstract
Stimulated neutrophil is the main source of oxidants/free radicals, that might contribute to the state of oxidative stress. Coffee has been well known to have a high antioxidant capacity, therefore it was plausible to hypothesize that coffee might reduce oxidants/radicals produced by neutrophil. This study aimed to analyze effect of coffee on superoxide radical produced by neutrophil in vitro. This study was conducted experimentally using the post test only control group design. Neutrophil was isolated from healthy human peripheral blood. Superoxide radical production was analyzed by NBT (nitro blue tetrazolium) assay. Results showed that coffee significantly (P < 0.05) reduced the number of neutrophils that produce superoxide radicals. In conclusion, coffee demonstrated antioxidant capacity against neutrophil superoxide radicals.
Potency of Fibraurea tinctora Lour. extract as anti-bacterial agents towards pathogenic bacteria
Authors: Zalizar L , Rahayu I D , Sujono  , Nor Y A 
Published: July 2019

Abstract
This research aimed to explore antibacterial activity of Fibraurea tinctora Lour. extracted by ethanol and hot water. The treatments of study consisted of six levels of F. tinctora plant extract (0 %, 0.625 %, 1.25 %, 2.50 %, 5.00 % and 10.0 %, respectively) either using ethanol or hot water, resulting in 12 experimental treatments according to 6 × 2 factorial arrangement in a completely randomized design. Each of the treatment was replicated three times. Results of this research showed that either ethanol or hot water F. tinctora extract have potency to control farm pathogenic bacteria. In the lowest concentration (0.625 %) both extract significantly inhibited bacteria growth (Minimum Inhibition Concentration). The highest antibacterial activity was in group that had the highest concentration (10 %) of extract in both of the bacteria. Staphylococcus aureus were more susceptible to the F. tinctora extract than Escherichia coli. Result from spectrophotometry UV-vis assessments showed that the total composition of tannin, alkaloid, and saponin from ethanol extract of F. tinctoria is higher than its water based extract. Meanwhile, phenol composition of water-based extract from F. tinctoria is higher than from ethanol extract.
Prospect of Fe non-heme on coffee flour made from solid coffee waste: Mini review
Authors: Setyobudi R H , Zalizar L , Wahono S K , Widodo W , Wahyudi A , Mel M , Prabowo B , Jani Y , Nugroho Y A , Liwang T , Zaebudin A 
Published: July 2019

Abstract
Coffee flour (CF) from coffee pulp or husk, solid waste of coffee processing have launched in Canada since 2015. This product is claimed as certified of gluten-free, vegan, kosher, paleo, and non-GMO. Coffe flour is stated to contain three times Fe content than fresh spinach (Spinacia oleracea L.). Several receipts of cookies, donuts, and cakes using CF has been introduced as wheat flour substitution. However, the scientific publication of CF impact for health does not appear until August 2018 yet. A review has been carried out using data on Google with a maximum publication age of 15 yr. This Fe non-heme prospect is allegedly unable to be absorbed optimally by the organism. Coffee pulp and husk contain an inhibitor, such as caffeine, polyphenol, calcium, dietary fiber, manganese, magnesium, and zinc; which detain Fe absorption. On the other hand, the promoter/enhancer of Fe absorption such as vitamin C, vitamin A, and amino acid was decreased in CF processing. Several types of research have to be conducted to tackle this problem in Faculty of Medicine and Faculty of Agriculture and Animal Husbandry University Muhammadyah of Malang, Indonesia.
Rapid reversed-phase high performance liquid chromatography assay of Tert-butylhydroquinone content in food products
Authors: Sutanto S , Purwanto M G M 
Published: July 2019

Abstract
The use of antioxidant has been widely applied in food industry to maintain the product’s condition to the end consumer. Tert-butylhydroquinone (TBHQ) is a synthetic aromatic organic compound which is often used as antioxidant in food, especially oil product and its derivatives. The use of TBHQ in food products has been limited by the government in most countries, including Indonesia. Therefore, the need for a rapid method to assay the concentration of TBHQ in products is quite high in food industry. In this article, we propose a rapid reversed-phase HPLC method to assay TBHQ content in food products. The isocratic system using 1 % acetic acid and acetonitrile in 3:2 ratio with 1 mL min−1 flow rate produces good separation of TBHQ. Target peak was eluted in 5 min and the whole procedure only need maximum of 18 min to elute all the sample component. The LOD of the method was determined at 0.2 mg L−1, while the lower limit of quantification was 0.5 mg L−1. The accuracy of the method has been proved with acceptable recovery ranging from 95 % to 105 %.
Beauty in the Neonatal Intensive Care Unit: Is Every Child a Pearl?
Authors: Thobaben James R , Rebecca Young Anna 
Published: July 2019

AbstractAll forms of beauty create appeal or enticement with moral significance. Sublime beauty draws one into a deep relationship that properly promotes the good and true. Parents tend to experience such beauty in their children, as eloquently described in works such as the 14th-century poem ‘The Pearl’, and they see this even when their children are desperately ill or dying. The experience of beauty in one’s child creates or reinforces the morality of caring. Unfortunately, at the end of modernity, the framing of beauty as only instrumental and subjective generally works against any recognition of dignity or respect for the very small pediatric patient. Practitioners who believe in the intrinsic value and dignity of persons as general concepts should recognize parental drawing toward their children as a particularization of a transcendental value.
Piss(ed): The Biopolitics of the Bathroom
Authors: Fischer Mia 
Published: July 2019

AbstractThis article analyzes two recent works by transgender performance artist Cassils, PISSED and Fountain (2017), which were created in response to the Trump administration's decision to rescind federal protections allowing transgender students to use the restroom of their choice. While Cassils primarily conceptualized PISSED/Fountain as a queering of binary, essentialist understandings of gendered embodiment, I draw on performance, queer, and critical ethnic studies to illustrate that these pieces simultaneously challenge other kinds of oppositional embodiments, particularly health versus disease and citizen versus alien and/or terrorist; conceptualizations the state frequently deploys to surveil and control marginalized populations. PISSED/Fountain offer audiences a new strategy for both exposing and contesting state violence: these pieces can be read as a politically strategic disidentification with the state's classification of certain bodies and their excretions as ``deviant'' and ``toxic'' in order to purposefully ``terrorize'' the state's bio- and necropolitical aims.
Host Plant Effects on Winter Moth (Lepidoptera: Geometridae) Larval Development and Survival
Authors: O’donnell Kaitlyn , Elkinton Joseph , Donahue Charlene , Groden Eleanor 
Published: July 2019

Abstract
The winter moth, Operophtera brumata (L.) is an invasive forest and agricultural pest in North America that causes severe defoliation to a wide range of host species. This study examines the differential larval densities, development, and survival on seven host species in midcoast Maine: red oak (Quercus rubra L., Fagales: Fagaceae), apple (Malus domestica L., Rosales: Rosaceae) and crab apple (Malus sp. L., Rosales: Rosaceae), red maple (Acer rubrum L., Sapindales: Sapindaceae), pin cherry (Prunus pensylvanica L., Rosales: Rosaceae), white birch (Betula papyrifera L., Fagales: Betulaceae), wild lowbush blueberry (Vaccinium angustiflolium L., Ericales: Ericaceae), and highbush blueberry (Vaccinium corymbosum L., Ericales: Ericaceae). We also explore the degree of synchrony between selected host plants and larval hatch and its effect on survival. We found that densities, development, and survival were significantly greater on red oak (Quercus rubra) and apple (Malus sp.) than on all other target species and were lowest on pin cherry (Prunus pennsylvanica). We found low larval densities in open, wild lowbush blueberry fields; however, larvae successfully fed and developed on wild lowbush blueberry in a laboratory setting. This suggests that winter moth is a potential pest to wild lowbush blueberry in Maine if the outbreak expands to include areas with wild lowbush blueberry production.
Ascending aorta and aortic root replacement (with or without valve sparing) in early childhood: surgical strategies and long-term outcomes
Authors: Moreau de Bellaing Anne , Pontailler Margaux , Bajolle Fanny , Gaudin Régis , Murtuza Bari , Haydar Ayman , Vouhé Pascal , Bonnet Damien , Raisky Olivier 
Published: July 2019

AbstractOBJECTIVESAortic root and ascending aorta replacements (AARs) are rarely required in the paediatric population. We report here a series of AAR performed in young children using different surgical techniques.METHODSBetween 1995 and 2017, 32 children under the age of 10 years (median age 5.4 years) underwent AAR procedures at our institution. Twenty-two (69%) had a connective tissue disease (infantile Marfan syndrome or Loeys–Dietz syndrome). We performed 11 AAR using a composite graft with a mechanical prosthesis and 21 valve-sparing procedures (10 Yacoub operations and 11 David operations). Median follow-up for operative survivors was 7.7 years (interquartile range 4.2–12.8 years).RESULTSThe cardiac-related early mortality rate was 6%. Patient survival was 91% at both 1 and 10 years. Eleven survivors (38%), all with a status of post-valve-sparing procedure, required an aortic root reintervention with an aortic valve replacement after a median interval of 4.2 years. Interestingly, only patients with infantile Marfan syndrome tended to be associated with risk of reoperation.CONCLUSIONSAortic root and AARs are safe in young children whatever the surgical procedure. Aortic valve-sparing procedures show good long-term results except in children with infantile Marfan syndrome whose ineluctable aortic annulus dilatation or aortic valve regurgitation requires reintervention after a short period.
Paralytic ileus precipitating platypnoea–orthodeoxia after right pneumonectomy
Authors: Whiteley Jennifer , Lynn Peter , Walker Niki , Butler John 
Published: July 2019

Abstract
A 78-year-old female underwent a right pneumonectomy for a neuroendocrine tumour. In the early postoperative phase, she developed a paralytic ileus and went on to develop breathlessness and orthostatic desaturation, which characterizes platypnoea–orthodeoxia. She was found to have an intra-atrial shunt on bubble echo, with equal atrial pressures. This was managed by device closure of the atrial connection, following which her condition improved.
Matthew Prior’s Alma: Affecting the Metaphysics
Authors: Loveridge Mark 
Published: July 2019

Abstract
This essay provides the first full descriptive and analytical account since 1946 of Matthew Prior’s poem Alma: or The Progress of the Mind (1719), which Alexander Pope described as a ‘master-piece’. Connections are developed between Prior’s use of effervescent figures of speech and narrative tricks, and uses of figurative metaphysical language in Isaac Newton’s Opticks, the Principia Mathematica, and the ‘Leibniz–Clarke’ controversy of 1715–1716. It emerges that the poem’s main subject is figurative language and the arguments it serves. Alma is a very unusual critique of aspects of Newtonian thought, employing techniques of ‘metaphysical’ poetry to poke fun at Newtonian metaphysics.
Improvement of laboratory skills of Chemical and Civil Engineering students using an interdisciplinary service-learning project for water quality and supply assessment in low-income homes
Authors: Piol María Natalia , Saralegui Andrea , Orero Gabriela , Boeykens Susana , Basack Silvana , Vullo Diana L 
Published: July 2019

ABSTRACT
The University of Buenos Aires (UBA) develops the UBANEX program, focused on service-learning projects for students involving social, environmental and public health concerns. One of the proposals was a collaborative project between UBA and the National University of General Sarmiento. Based on the hypothesis that students’ voluntary involvement in social concerns improves their attitudes towards themselves and learning, the aim was to focus on the development of social and professional skills by implementing an interdisciplinary work for water quality and supply assessment in low-income homes from a southern district of the Buenos Aires Metropolitan Area. Eighteen volunteers—Chemical and Civil Engineering students—were recruited during August–December 2016. Tasks were distributed according to their interests: survey making, sampling, lab analysis, infrastructure checking, etc. Volunteers were surveyed in social involvement, lab skills, data compilation and analysis, leading to a final report with recommendations for a proper water use. The survey results compiled their feedback: 72% admitted an update on water quality problems, 60% learned new lab techniques and were able to analyze results, 89% supported the University’s involvement in social concerns and 56% expanded their opinion about the professional field. The students confirmed their interest in participating in the next UBANEX project.
Molecular and Pathogenic Characteristics of Paecilomyces formosus, a New Causal Agent of Oak Tree Dieback in Iran
Authors: Sabernasab Mohammad , Jamali Samad , Marefat Alireza , Abbasi Saeed 
Published: July 2019

AbstractOak dieback is one of the most important diseases that presently affects the Kermanshah oak forests (West Iran). During the period from 2013 to 2015, oak trees exhibiting branch dieback were sampled, and fungal colonies resembling those of the Paecilomyces sp. were obtained from diseased tissues. Based on morphology, physiology, and phylogeny of the internal transcribed spacer rDNA, all isolates were identified as Paecilomyces formosus. Pathogenicity tests in vivo were made on 2-year-old seedlings, potted Q. brantii plants, and excised branch sections under controlled conditions. Inoculated seedlings produced characteristic symptoms, and subsequent pathogen recovery confirmed pathogenicity. We determined these to be thermophilic fungi, which may be related to warming and drought. This is the first report of Paecilomyces formosus as the causal agent of Q. brantii dieback in Iran and the world.
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial
Authors: Sales Lucas Peixoto , Pinto Ana Jéssica , Rodrigues Samara Ferrari , Alvarenga Jackeline Couto , Gonçalves Natalia , Sampaio-Barros Marília M , Benatti Fabiana Braga , Gualano Bruno , Rodrigues Pereira Rosa Maria 
Published: July 2019

Abstract

Background
Creatine supplementation could be a nonexpensive, safe, and effective dietary intervention to counteract bone loss. The aim of this study was to investigate whether long-term creatine supplementation can improve bone health in older, postmenopausal women.

Methods
A double-blind, placebo-controlled, parallel-group, randomized trial was conducted between November 2011 and December 2017 in Sao Paulo, Brazil. Two hundred postmenopausal women with osteopenia were randomly allocated to receive either creatine monohydrate (3 g/d) or placebo for 2 years. At baseline and after 12 and 24 months, we assessed areal bone mineral density (aBMD; primary outcome), lean and fat mass (through dual X-ray absorptiometry), volumetric BMD and bone microarchitecture parameters, biochemical bone markers, physical function and strength, and the number of falls and fractures. Possible adverse effects were self-reported.

Results
Lumbar spine (p &lt; .001), femoral neck (p &lt; .001), and total femur aBMD (p = .032) decreased across time; however, no interaction effect was observed (all p &gt; .050). Bone markers, microarchitecture parameters, and the number of falls/fractures were not changed with creatine (all p &gt; .050). Lean mass and appendicular skeletal muscle mass increased throughout the intervention (p &lt; .001), with no additive effect of creatine (p = .731 and p = .397, respectively). Creatine did not affect health-related laboratory parameters.

Conclusion
Creatine supplementation more than 2 years did not improve bone health in older, postmenopausal women with osteopenia, nor did it affect lean mass or muscle function in this population. This refutes the long-lasting notion that this dietary supplement alone has osteogenic or anabolic properties in the long run.

Clinical trial registry
Clinicaltrials.gov: NCT: 01472393.
Using the van Noordwijk and de Jong Resource Framework to Evaluate Glucocorticoid-Fitness Hypotheses
Authors: Breuner Creagh W , Berk Sara A 
Published: July 2019

Abstract
Ten years ago, two reviews clarified the need to tie glucocorticoid (GC) levels directly to survival and reproductive measures. Three primary hypotheses emerged from that work: the CORT-Fitness hypothesis, the CORT-Adaptation hypothesis, and the CORT-Tradeoff hypothesis. The two reviews have since been cited nearly 900 times, but no clear consensus has emerged supporting one hypothesis over another. We propose that resource availability may be a major confound across studies. Life-history investment is determined by both allocation and acquisition, but current literature testing among the three GC-fitness hypotheses rarely incorporate metrics of resource availability. In 1986, van Noordwijk and de Jong (vN and dJ) proposed the acquisition/allocation Y-model to explain positive versus negative correlations between reproduction and survival across individuals. Their model elevated resources as critical to evaluating individual allocation strategies (favoring reproduction vs. survival), and therefore provides the ideal framework for testing across the three CORT hypotheses. Here, we review the three hypotheses in light of the last 10 years of data, introduce the vN and dJ framework as a model for fitness/GC hypothesis testing, and discuss best practices for using this framework. We believe incorporation of resource availability will reduce unexplained variability in GC-fitness tests, clarify support among the three hypotheses, and allow for greater power in testing across other context dependencies (e.g., life-history strategy) that likely regulate differential allocation to reproduction versus survival as GCs increase.
Improving Case-Based Meningitis Surveillance in 5 Countries in the Meningitis Belt of Sub-Saharan Africa, 2015–2017
Authors: Mbaeyi Sarah A , Lingani Clement , Diallo Alpha Oumar , Bicaba Brice , Ouédraogo-Traoré Rasmata , Acyl Mahamat , Gamougame Kadidja , Coulibaly Oumou , Coulibaly Souleymane , Zaneidou Maman , Sidikou Fati , Nikiema Christelle , Sadji Adodo Yao , Aké Flavien , Tarbangdo Félix , Sakande Souleymane , Tall Haoua , Njanpop-Lafourcade Berthe-Marie , Moïsi Jennifer , N’diaye Aboubacar , Bwaka Ado , Bita Andre , Fernandez Katya , Poy Alain , Soeters Heidi M , Vuong Jeni , Novak Ryan , Ronveaux Olivier ,   MenAfriNet Consortium
Published: July 2019

Abstract

Background
The MenAfriNet consortium was established in 2014 to support implementation of case-based meningitis surveillance in 5 countries in the meningitis belt of sub-Saharan Africa: Burkina Faso, Chad, Mali, Niger, and Togo. Assessing surveillance performance is critical for interpretation of the collected data and implementation of future surveillance-strengthening initiatives.

Methods
Detailed epidemiologic and laboratory data were collected on suspected meningitis cases through case-based meningitis surveillance in participating districts in 5 countries. Performance of case-based surveillance was evaluated through sensitivity of case ascertainment in case-based versus aggregate meningitis surveillance and an analysis of surveillance indicators.

Results
From 2015 to 2017, 18 262 suspected meningitis cases were identified through case-based surveillance and 16 262 were identified through aggregate surveillance, for a case ascertainment sensitivity of 112.3%. Among suspected cases, 16 885 (92.5%) had a cerebrospinal fluid (CSF) specimen collected, 13 625 (80.7%) of which were received at a national reference laboratory. Among these, 13 439 (98.6%) underwent confirmatory testing, and, of those tested, 4371 (32.5%) were confirmed for a bacterial pathogen.

Conclusions
Overall strong performance for case ascertainment, CSF collection, and laboratory confirmation provide evidence for the quality of MenAfriNet case-based surveillance in evaluating epidemiologic trends and informing future vaccination strategies.