bluuebunny/crossref_metadata_2025_split huggingface dataset:
The study of long-term fluctuations in the dates of ice formation and ice destruction in the rivers of the Votkinsk reservoir catchment
Authors: Kalinin V G , Chichagov V V 
Published: September 2019

Abstract
A statistical analysis of the dates of ice formation and ice destruction in the rivers of the Votkinsk reservoir catchment was carried out, including testing the hypothesis of randomness for both the full series of observations and their parts; autocorrelation diagnostics of the time series; verification of the homogeneity hypothesis of the series of observations and the aggregate index. The results indicate that there are statistically significant changes in the ice formation and ice destruction dates occurring in recent years in the rivers of the Votkinsk reservoir catchment.
Mathematical modelling of water turbidity in the water body
Authors: Rakhuba A V , Shmakova M V 
Published: September 2019

Abstract
Suspended solids spreading in water reservoir is pre-defined by morphometry of the latter, inflow and outflow location, solids ingress with inflow and meteorological conditions. Configuration particulars of Kuybyshev water reservoir and its large elongation over longitude lead to irregular turbidity spreading and irregular unit flow of sediment. Represented spreading map of max. water turbidity values in Kuybyshev water reservoir is built at hypothetic initiation of bed solid stirring processes in water area. The acquired spreading map of max. water turbidity enables assessing of water areas with the most adverse hydrodynamic conditions that can form the basis to issue further recommendation on actions connected to dredging or damping.
Shallow zones and their role in the ecosystem of the Sheksna Reach of the Rybinsk Reservoir
Authors: Zakonnov V V , Chuiko G M , Zakonnova A V , Tsvetkov A I 
Published: September 2019

Abstract
Based on the materials of monitoring of bottom sediments and a special voyage of the RV Akademik Topchiev in 2016–2018 in the Sheksna Reach of the Rybinsk Reservoir which is a recipient of semi-purified waste waters from chemical and metallurgical enterprises of the city of Cherepovets, the role of the littoral zone in dilution of pollutants in water and their accumulation in bottom sediments in the profundal zone of the flooded channel of the Sheksna River to the settlement of Gayutino has been estimated. The results indicate that runoff and wind-induced currents promote intensive horizontal transfer and dilution of sewages in a shallow zone, and hydrodynamic conditions in a deep-water zone promote vertical sedimentation and irretrievable deposition of pollutants in bottom sediments at depths of more than 6 m. Chemical and biological processes leading to self-purification of industrial and domestic wastewaters and contributing to the maintenance of optimal water quality take place along with the physical processes.
Evaluation of dissolved Fe and Mn fluxes at the water/bottom border for various soil types
Authors: Lomova D V , Kremenetskaya E R , Efimova L E , Terskaya E V , Serenkaya E P 
Published: September 2019

Abstract
On the basis of field experiments the Fe and Mn fluxes for various types of soils were evaluated. It was found that dissolved Fe and Mn fluxes in hydrogen sulphide black silts are significantly lower in the presence of gas bubbles than in their absence.
Scope and structure of diffuse pollution of the Kama reservoir
Authors: Lepikhin A P , Wozniak A A , Lyakhin Yu S , Bogomolov A V 
Published: September 2019

Abstract
The natural hydrochemical regime and technogenic pollution of the upper part of the Kama reservoir are considered. It is shown that the composition of pollutants in industrial pollution is determined by the nature of the activities of enterprises engaged in the discharge of wastewater. The volume and chemical composition of discharged wastewater is taken into account through the reporting form 2-TP (water management). However, the increase in the pollutant volume in the reservoir site turns out to be ten times more than the volume of pollutant discharges from the declared sources. This discrepancy is due to diffuse pollution. The article presents a method for calculating the volume of diffuse pollution of a water body. The uneven distribution of pollution across the width and depth of the water body is shown.
Possible sources of pollution by oil products of water body in karst area
Authors: Buzmakov S A , Andreev D N , Zaytsev A A , Khotyanovskaya Y V , Voronov G A 
Published: September 2019

Abstract
This article is devoted to the study of the content of petroleum products in surface and groundwater in the karst area. The hydrological and hydrochemical features of the Yasyl river, the dynamics of oil content in three hydrological phases in the period from 2016 to 2018 are considered. The time and spatial features of the distribution of petroleum products along the length of the water stream are revealed. The hypotheses of the origin of oil products in a water body were put forward.
Down-regulation of CCR7 via AKT pathway and GATA2 inactivation suppressed trophoblast migration and invasion in recurrent spontaneous abortion†
Authors: Luan Xiaorui , Li Shang , Zhao Jun , Zhai Junyu , Liu Xiaojing , Chen Zi-Jiang , Li Weiping , Du Yanzhi 
Published: September 2019

AbstractThe underlying mechanism of the chemokine-C receptor 7 (CCR7) that leads to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. CCR7 is considered crucial for migration and invasion and has been associated with the risk of miscarriage. However, the functional role of CCR7 in RSA is not fully understood. Our study found that CCR7 mRNA and protein abundance were significantly decreased in the villous from RSA patients compared with healthy controls. Knockdown of CCR7 caused a significant reduction of migration and invasion in JAR and JEG-3 cells. Meanwhile, CCR7 functioned as a positive upstream factor of the AKT pathway contributing to the expression of GATA2, promoting trophoblast migration, and invasion via MMP2. Notably, a decreased abundance of CCR7 was positively correlated with the phosphorylation of AKT and with an abundance of GATA2 and MMP2 in human villous specimens of RSA compared with the control group. CCL19, a ligand of CCR7, could promote trophoblast migration and invasion by activating the deregulation of the CCR7-mediated pathway in RSA. We are convinced that CCR7 and its downstream factors may be possible mechanisms for the pathogenesis of RSA.
Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows†
Authors: Costermans N G J , Teerds K J , Middelkoop A , Roelen B A J , Schoevers E J , van Tol H T A , Laurenssen B , Koopmanschap R E , Zhao Y , Blokland M , van Tricht F , Zak L , Keijer J , Kemp B , Soede N M 
Published: September 2019

AbstractMetabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (−26%) and cumulus–oocyte complexes showed less expansion after 22 h in vitro maturation (−26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (−56%) and steroid levels (e.g., β-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence.
Estrous cycle impacts microRNA content in extracellular vesicles that modulate bovine cumulus cell transcripts during in vitro maturation†
Authors: de Ávila Ana Clara Faquineli Cavalcante Mendes , Bridi Alessandra , Andrade Gabriella Mamede , del Collado Maite , Sangalli Juliano Rodrigues , Nociti Ricardo Perecin , da Silva Junior Wilson Araújo , Bastien Alexandre , Robert Claude , Meirelles Flávio Vieira , Perecin Felipe , da Silveira Juliano Coelho 
Published: September 2019

AbstractExtracellular vesicles (EVs) are nanoparticles secreted by ovarian follicle cells. Extracellular vesicles are an important form of intercellular communication, since they carry bioactive contents, such as microRNAs (miRNAs), mRNAs, and proteins. MicroRNAs are small noncoding RNA capable of modulating mRNA translation. Thus, EVs can play a role in follicle and oocyte development. However, it is not clear if EV contents vary with the estrous cycle stage. The aim of this study was to investigate the bovine miRNA content in EVs obtained from follicles at different estrous cycle stages, which are associated with different progesterone (P4) levels in the follicular fluid (FF). We collected FF from 3 to 6 mm follicles and evaluated the miRNA profile of the EVs and their effects on cumulus-oocyte complexes during in vitro maturation. We observed that EVs from low P4 group have a higher abundance of miRNAs predicted to modulate pathways, such as MAPK, RNA transport, Hippo, Cell cycle, FoxO, oocyte meiosis, and TGF-beta. Additionally, EVs were taken up by cumulus cells and, thus, affected the RNA global profile 9 h after EV supplementation. Cumulus cells supplemented with EVs from low P4 presented upregulated genes that could modulate biological processes, such as oocyte development, immune responses, and Notch signaling compared with genes of cumulus cells in the EV free media or with EVs from high P4 follicles. In conclusion, our results demonstrate that EV miRNA contents are distinct in follicles exposed to different estrous cycle stage. Supplementation with EVs impacts gene expression and biological processes in cumulus cells.
Inference on finite-population treatment effects under limited
overlap
Authors: Hong Han , Leung Michael P , Li Jessie 
Published: September 2019

Summary
This paper studies inference on finite-population average and local average treatment effects under limited overlap, meaning that some strata have a small proportion of treated or untreated units. We model limited overlap in an asymptotic framework, sending the propensity score to zero (or one) with the sample size. We derive the asymptotic distribution of analogue estimators of the treatment effects under two common randomization schemes: conditionally independent and stratified block randomization. Under either scheme, the limit distribution is the same and conventional standard error formulas remain asymptotically valid, but the rate of convergence is slower the faster the propensity score degenerates. The practical import of these results is two-fold. When overlap is limited, standard methods can perform poorly in smaller samples, as asymptotic approximations are inadequate owing to the slower rate of convergence. However, in larger samples, standard methods can work quite well even when the propensity score is small.
Early-life exposure to traffic-related air pollution and child anthropometry
Authors: Sears Clara G. , Mueller-Leonhard Catrina , Wellenius Gregory A. , Chen Aimin , Ryan Patrick , Lanphear Bruce P. , Braun Joseph M. 
Published: September 2019

Background:Early-life exposure to traffic-related air pollution may decrease fetal growth and increase childhood obesity risk. Our objective was to evaluate the relationship of early-life exposure to traffic-related air pollution with birthweight in term newborns and obesity at age 7–8 years in two prospective birth cohorts in Cincinnati, OH (the Health Outcomes and Measures of the Environment [HOME] Study and Cincinnati Childhood Allergy and Air Pollution Study [CCAAPS]).Methods:We estimated elemental carbon attributable to traffic (ECAT) exposure at residential addresses during pregnancy with a validated land use regression model. We assessed birthweight among term infants using birth records or parent report (HOME Study n = 333 and CCAAPS n = 590). We measured children’s weight and height at 7–8 years and calculated age- and sex-specific body mass index (BMI) z-scores (HOME Study n = 198 and CCAAPS n = 459). Using multivariable linear regression, we estimated the difference in term birthweight and BMI z-score per interquartile range (IQR) increase in ECAT concentrations in each cohort separately and in the pooled sample.Results:In adjusted models, ECAT exposure was not associated with lower birthweight (pooled sample β: 30 g; 95% CI = −6, 66) or with higher BMI z-score (pooled sample β: −0.04; 95% CI = −0.15, 0.08). Infant sex modified the association between ECAT and birthweight (P= 0.05). Among male newborns, higher ECAT concentrations were associated with higher birthweight (β: 61 g; 95% CI = 9, 113), but we observed no association among female newborns (β: −9 g; 95% CI = −58, 41).Conclusions:In contrast to some prior studies, early-life traffic-related air pollution exposure was not associated with lower birthweight or increased childhood adiposity in these two cohorts.
Tacrolimus Area Under the Concentration Versus Time Curve Monitoring, Using Home-Based Volumetric Absorptive Capillary Microsampling
Authors: Gustavsen Marte T. , Midtvedt Karsten , Vethe Nils T. , Robertsen Ida , Bergan Stein , Åsberg Anders 
Published: September 2019

Background:Therapeutic drug monitoring (TDM) of tacrolimus (Tac) is mandatory in renal transplant recipients (RTxR). Area under the concentration versus time curve (AUC) is the preferred measure for Tac exposure; however, for practical purposes, most centers use trough concentrations as a clinical surrogate. Limited sampling strategies in combination with population pharmacokinetic model–derived Bayesian estimators (popPK-BE) may accurately predict individual AUC. The use of self-collected capillary microsamples could simplify this strategy. This study aimed to investigate the potential of AUC-targeted Tac TDM using capillary microsamples in combination with popPK-BE.Methods:A single-center prospective pharmacokinetic study was conducted in standard-risk RTxR (n = 27) receiving Tac twice daily. Both venous and capillary microsamples (Mitra; Neoteryx, Torrance, CA) were obtained across 2 separate 12-hour Tac dosing intervals (n = 13 samples/AUC). Using popPK-BE, reference AUC (AUCref) was determined for each patient using all venous samples. Different limited sampling strategies were tested for AUC predictions: (1) the empiric sampling scheme; 0, 1, and 3 hours after dose and (2) 3 sampling times determined by the multiple model optimal sampling time function in Pmetrics. Agreement between the predicted AUCs and AUCrefwere evaluated using C-statistics. Accepted agreement was defined as a total deviation index ≤±15%.Results:The AUC from capillary microsamples revealed high accuracy and precision compared with venous AUCref, and 85% of the AUCs had an error within ±11.9%. Applying microsamples at 0, 1, and 3 hours after dose predicted venous AUCrefwith acceptable agreement. Patients performed self-sampling with acceptable accuracy.Conclusions:Capillary microsampling is patient-centered, making AUC-targeted TDM of Tac feasible without extended hospital stays. Samples obtained 0, 1, and 3 hours after dose, combined with popPK-BE, accurately predict venous Tac AUC.
Comparative effects of high-intensity interval training with combined training on physical function markers in obese postmenopausal women: a randomized controlled trial
Authors: Nunes Paulo R. P. , Martins Fernanda M. , Souza Aletéia P. , Carneiro Marcelo A. S. , Nomelini Rosekeila S. , Michelin Márcia A. , Murta Eddie F. C. , de Oliveira Erick P. , Orsatti Fábio L. 
Published: September 2019

Abstract

Objectives:
This study compared the effects of high-intensity interval training (HIIT) with effects of combined training (CT) on physical function, body composition, and muscle strength in obese postmenopausal women (PW) (trial registration: NCT03200639).

Methods:
PW were randomized to CT (n = 12) and HIIT (n = 12). The CT group performed 30 minutes of moderate walking at 70% of maximum heart rate (MHR) and five resistance exercises at 70% of one repetition maximum (1RM) for 12 weeks. The HIIT group performed 10 sets of vigorous exercises (30 seconds (s) of stair climbing and 30 s of body weight squats) at >80% MHR interspersed by a light walk (recovery period at 60% MHR).

Results:
Both groups reduced body fat percentage (0.5%), chair stand (3 s) and increased leg lean mass (0.3 kg). Only the CT, however, increased muscle strength (29%) and fast walking speed (5%) compared with HIIT. The fast walking speed changes were partially explained by the muscle strength changes (36%, r = 0.60, P = 0.027) in the CT group.

Conclusions:
These results suggest that HIIT is an alternative time-efficient protocol for improving chair stand and body composition when compared with CT, whereas only CT is an efficient protocol for improving muscular strength and fast walking speed in obese PW. Thus, CT must be prioritized when the increase of muscular strength and fast walking speed are the goals of training.

Video Summary:
Supplemental Digital Content 1, http://links.lww.com/MENO/A443.
Effect of Preexisting and Co-Occurring Comorbid Conditions on Recovery in the 5 Years After Rehabilitation for Traumatic Brain Injury
Authors: Corrigan John D. , Zheng Tianyu , Pinto Shanti M. , Bogner Jennifer , Kean Jacob , Niemeier Janet P. , Guerrier Tami P. , Haaland Benjamin , Horn Susan D. 
Published: September 2019

Objective:
To determine the relationship between comorbid health conditions and the trajectory of functional recovery 5 years following traumatic brain injury (TBI) rehabilitation.

Setting:
Two acute rehabilitation facilities.

Participants:
A total of 407 patients with primary diagnosis of TBI.

Design:
Prospective, observational.

Main Measures:
Functional Independence Measure Cognitive and Motor scores.

Results:
Female gender was negatively associated with the trajectory of motor recovery (P < .001). TBI severity was negatively associated with both motor and cognitive recovery and interacted with time after injury (both Ps < .0001). Hypertension was negatively associated with both motor (P < .0001) and cognitive (P = .0121) recovery, although this relationship diminished over time for motor function (P = .0447). Cardiac conditions were negatively associated with motor recovery (P = .0204), and rate of cognitive recovery was more rapid for patients with cardiac conditions (P = .0088). Depressed patients recovered cognitive function more quickly than those who were not depressed (P = .0196). Diabetes was negatively associated with motor function (P = .0088). Drug/alcohol use was positively associated with motor function (P = .0036).

Conclusions:
Injury severity remains an important predictor of long-term recovery; however, certain comorbid medical conditions are negatively associated with functional abilities over the first 5 years after injury. Patients being discharged from TBI rehabilitation with comorbid cardiac, hypertensive, diabetic, and/or depressive conditions may benefit from early and ongoing clinical surveillance.
Self-Reported Lifetime Concussion Among Adults: Comparison of 3 Different Survey Questions
Authors: Daugherty Jill , DePadilla Lara , Sarmiento Kelly , Breiding Matthew J. 
Published: September 2019

Objective:
Because of limitations in current national data sets, respondent self-report may be critical to obtaining concussion prevalence estimates. We examined whether self-report of lifetime concussion among adults varies with the provision of a concussion definition and by the content of that definition.

Setting and Participants:
A convenience sample of 6427 American adults who participated in the 2018 Porter Novelli SpringStyles survey.

Design:
Cross-sectional.

Main Measures:
Frequency of self-reported concussion by variation in concussion definition.

Results:
A quarter of respondents (28.9%) reported experiencing a concussion in their lifetime. While concussion prevalence varied by demographic characteristics, it did not vary significantly by concussion definition. Variation in concussion definition did not result in differences related to recency of last concussion, mechanism of injury, or respondent activity engaged in during which they sustained their most recent concussion.

Conclusion:
The current study suggested that in this sample of adults, the percentage reporting a concussion did not significantly vary by whether a concussion definition was provided or by the content of the definition. However, research suggests that prompting about mechanism of injury, listing symptoms individually, and considering only athletic populations may affect estimates and these factors should be included in future question comparisons.
Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors
Authors: Brierley Stuart M. , Goh Kelvin G.K. , Sullivan Matthew J. , Moore Kate H. , Ulett Glen C. , Grundy Luke 
Published: September 2019

Abstract
The bladder is innervated by primary afferent nerve fibres that detect bladder distension and, through projections into the spinal cord, provide sensory input to the central nervous system circuits regulating bladder sensation and function. Uropathogenic E. coli (UPEC) bacteria are the primary cause of urinary tract infection (UTI) in adults, inducing clinical symptoms characterised by exaggerated bladder sensation, including urgency, frequency, and pelvic pain. However, the mechanisms underlying UTI-induced modulation of bladder afferent function are yet to be explored. Here, we isolated supernatants from the bladders of female mice acutely infected with UPEC (strain CFT073), or those sham-treated with phosphate buffered saline. Supernatants were then applied into the bladder lumen of healthy donor mice, and multiunit bladder afferent nerve responses to distension measured ex-vivo. Supernatant constituents from UPEC or sham-treated mice were analysed using a mouse cytokine multiplex assay. Supernatants from UPEC-infected mice significantly enhanced bladder afferent firing to distension in the absence of changes in muscle compliance. Further evaluation revealed that UPEC supernatants exclusively sensitised high-threshold bladder mechanoreceptors to graded bladder distension and also recruited a population of “silent nociceptors” to become mechanosensitive, thereby amplifying bladder afferent responses to physiological stimuli. UPEC supernatants contained significantly elevated concentrations of a range of cytokines released from innate immune cells, including but not limited to TNF-α, IL-1β, IL-6, IL-17, IFN-gamma, and MCP-1. These data provide novel mechanistic insight into how UPEC-mediated UTI induces bladder hypersensitivity and the symptoms of frequency, urgency, and pelvic pain.