bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Hydration of Thermally Activated Water-Washed Kaolins in Cement Mortar
Authors: Wang Guiming , Ge Keyu , Sun Tao , Shui Zhonghe , Hu Teng , Jiang He , Wang Ziyan 
Published: August 2019

Abstract
This article investigated the hydration process, mechanical properties, and pore distribution of two kinds of thermally activated water-washed kaolin in cement-based materials. The metakaolin was obtained through the calcination process at 600°C–700°C for 3 h, and its pozzolanic activity was evaluated using the X-ray diffraction analysis of metakaolin-lime blends. The results indicated that the well-crystallized kaolinite in Maoming, China, had a higher pozzolanic activity than the poorly crystallized kaolinite from Beihai, China, when calcined at the same temperature. The highest pozzolanic activity was observed during the calcination at 650°C, which also indicated a turning point for the specific surface area and the particle size distribution of both kaolins. Furthermore, when mixed at a replacement level of 10 wt%, the metakaolin in Maoming showed the promotion of the hydration of cement to a greater extent, an effective reduction in harmful voids (&gt;20 nm), and a higher compressive strength (i.e., an increase by 120–140 %).
Study on Workability and Skid Resistance of Bio-Oil–Modified Fog Seal with Sand
Authors: Feng Ponan , Wang Hainian , Zhang Xiang , Mohd Hasan Mohd Rosli , You Zhanping , Gao Junfeng 
Published: August 2019

Abstract
The objective of this study is to evaluate different fog seal materials, including Tianjin BEST - micro-seal bonding reductant (BEST-MBR), American MasterSeal, and a newly designed bio-oil–modified fog seal with sand (BFSS) using various sand contents. The workability of all materials was tested based on the fluidity test, seepage performance test, and the indoor skid resistance test. A new method to evaluate the surface texture of solidified fog seal with sand (FSS) material was performed based on the aggregate image measurement system II. The test results show that when the seepage flow evaluation index is set to a 1.5-mm seepage width, the seepage flow value should not be less than 0.2, whereas when the width is 2 mm, the flow value should not be less than 0.7. In addition, the surface texture evaluation indicates that some smaller grooves are formed around the sand particles after the BFSS is solidified and the structural depth of the material surface is increased. The BFSS material with 20 % sand content is slightly better than the BEST-MBR in terms of skid resistance, whereas it is still lower than MasterSeal. The addition of bio-oil lowers the need for asphalt binder, leading to energy savings. Thus, BFSS is a relatively desirable FSS material.
Clinical presentation and management of primary ovarian neuroendocrine tumor in multiple endocrine neoplasia type 1
Authors: Jhawar Sakshi , Lakhotia Rahul , Suzuki Mari , Welch James , Agarwal Sunita K , Sharretts John , Merino Maria , Ahlman Mark , Blau Jenny E , Simonds William F , Del Rivero Jaydira 
Published: August 2019

Summary
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by parathyroid, anterior pituitary and enteropancreatic endocrine cell tumors. Neuroendocrine tumors occur in approximately in 5–15% of MEN1 patients. Very few cases of ovarian NETs have been reported in association with clinical MEN1 and without genetic testing confirmation. Thirty-three-year-old woman with MEN1 was found to have right adnexal mass on computed tomography (CT). Attempt at laparoscopic removal was unsuccessful, and mass was removed via a minilaparotomy in piecemeal fashion. Pathology showed ovarian NET arising from a teratoma. Four years later, patient presented with recurrence involving the pelvis and anterior abdominal wall. She was treated with debulking surgery and somatostatin analogs (SSAs). Targeted DNA sequencing analysis on the primary adnexal mass as well as the recurrent abdominal wall tumor confirmed loss of heterozygosity (LOH) at the MEN1 gene locus. This case represents to our knowledge, the first genetically confirmed case of ovarian NET arising by a MEN1 mechanism in a patient with MEN1. Extreme caution should be exercised during surgery as failure to remove an ovarian NET en masse can result in peritoneal seeding and recurrence. For patients with advanced ovarian NETs, systemic therapy options include SSAs, peptide receptor radioligand therapy (PRRT) and novel agents targeting mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF).

Learning points:

Ovarian NET can arise from a MEN1 mechanism, and any adnexal mass in a MEN1 patient can be considered as a possible malignant NET.

Given the rarity of this disease, limited data are available on prognostication and treatment. Management strategies are extrapolated from evidence available in NETs from primaries of other origins.

Care should be exercised to remove ovarian NETs en bloc as failure to do so may result in peritoneal seeding and recurrence.

Treatment options for advanced disease include debulking surgery, SSAs, TKIs, mTOR inhibitors, PRRT and chemotherapy.
Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity
Authors: Lake J E , Debroy P , Ng D , Erlandson K M , Kingsley L A , Palella F J , Budoff M J , Post W S , Brown T T 
Published: August 2019

Objectives
Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV.

Design
Cross-sectional analysis of men enrolled in the Multicenter AIDS Cohort Study.

Methods
Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density (Hounsfield units, HU; less negative = more dense) were quantified from computed tomography (CT) scans. Multivariate linear regression models described relationships between abdominal AT density and circulating biomarker concentrations.

Results
HIV+ men had denser SAT (−95 vs −98 HU HIV−, P < 0.001), whereas VAT density was equivalent by HIV serostatus men (382 HIV−, 462 HIV+). Historical thymidine analog nucleoside reverse transcriptase inhibitor (tNRTI) use was associated with denser SAT but not VAT. In adjusted models, a 1 s.d. greater SAT or VAT density was associated with higher levels of adiponectin, leptin, HOMA-IR and triglyceride:HDL cholesterol ratio and lower hs-CRP concentrations in HIV− men. Conversely, in HIV+ men, each s.d. greater SAT density was not associated with metabolic parameter improvements and was significantly (P < 0.05) associated with higher systemic inflammation. Trends toward higher inflammatory biomarker concentrations per 1 s.d. greater VAT density were also observed among HIV+ men.

Conclusions
Among men living with HIV, greater SAT density was associated with greater systemic inflammation independent of SAT area. AT density measurement provides additional insight into AT density beyond measurement of AT quantity alone, and may have implications for metabolic disease risk.
A Bayesian Genomic Multi-output Regressor Stacking Model for Predicting Multi-trait Multi-environment Plant Breeding Data
Authors: Montesinos-López Osval A , Montesinos-López Abelardo , Crossa José , Cuevas Jaime , Montesinos-López José C , Gutiérrez Zitlalli Salas , Lillemo Morten , Philomin Juliana , Singh Ravi 
Published: August 2019

Abstract
In this paper we propose a Bayesian multi-output regressor stacking (BMORS) model that is a generalization of the multi-trait regressor stacking method. The proposed BMORS model consists of two stages: in the first stage, a univariate genomic best linear unbiased prediction (GBLUP including genotype × environment interaction GE) model is implemented for each of the L traits under study; then the predictions of all traits are included as covariates in the second stage, by implementing a Ridge regression model. The main objectives of this research were to study alternative models to the existing multi-trait multi-environment (BMTME) model with respect to (1) genomic-enabled prediction accuracy, and (2) potential advantages in terms of computing resources and implementation. We compared the predictions of the BMORS model to those of the univariate GBLUP model using 7 maize and wheat datasets. We found that the proposed BMORS produced similar predictions to the univariate GBLUP model and to the BMTME model in terms of prediction accuracy; however, the best predictions were obtained under the BMTME model. In terms of computing resources, we found that the BMORS is at least 9 times faster than the BMTME method. Based on our empirical findings, the proposed BMORS model is an alternative for predicting multi-trait and multi-environment data, which are very common in genomic-enabled prediction in plant and animal breeding programs.
THE DETERMINANTS OF OUTWARD FOREIGN DIRECT INVESTMENT FROM ASEAN
Authors: Ibrahim Alisa , Driffield Nigel , Glaister Keith 
Published: August 2019

Purpose of Study: This study investigates the determinants of ASEAN outward foreign direct investment (OFDI) and the extent to which the four general motives of OFDI (market seeking, efficiency-seeking, resource-seeking, strategic-assets-seeking) can explain the phenomenon in the four chosen ASEAN countries (Malaysia, Singapore, Thailand and Indonesia). Methodology: We used panel data from 2001 – 2016 and the Tobit regression model to ascertain the results. We found that each country possibly has slightly different motives between each other although market seeking is seen as the general motive. As most of the previous studies focused on other developing countries such as BRICS, this study contributes to the small but growing literature of ASEAN economies. Furthermore, the usage of the Tobit regression Model helps us in explaining the variables with zero value, hence yielding a more informative result. Results: We found that, in general, some determinants were consistent with findings in the literature, while others need further investigation. Lastly, based on the findings, we can conclude that the mainstream theory of outward FDI applies to ASEAN.
Posisi Guru sebagai Orang Tua dan Murid sebagai Anak Menurut Perspektif Al-Qur’an
Authors: Malik Muhammad Abdul 
Published: August 2019

Penelitian ini bertujuan untuk menggambarkan bagaimana hubungan antara guru dan murid yang seharusnya, berdasarkan ayat-ayat yang membicarakan hubungan orang tua dengan anak dan ayat-ayat yang membicarakan tentang adab terhadap nabi. Penelitian ini merupakan penelitian kualitatif dengan menggunakan analisis deskriptif dengan landasan utama menggunakan beberapa literatur tafsir Alquran dan sebagai sumber sekunder dari literatur lain yang berhubungan dengan topik pembahasan. Adapun sikap yang harus dilakukan guru terhadap murid adalah (1) memanggil murid denan panggilan kasih sayang, panggilan yang disenangi oleh murid (2) aktif memberikan nasihat yang positif dengan lemah lembut, dengan cara yang baik. Sedangkan bagaimana seorang murid bersikap terhadap gurunya adalah (1) menghormati gurunya dengan sebenar-benarnya karena guru juga membawa peran kenabian, yaitu sebagai muallim (2) jangan meninggikan suara di depan guru (3) banyak berterimakasih kepada guru atas jasa dan ilmu yang telah diberikan (4) tidak berkata yang tidak pantas atau membentak guru (5) bergaul dan memanggil guru dengan lembut. Diharapkan penelitian ini bisa membantu mewujudkan dunia pendidikan yang lebih baik, yang membuat guru dan murid saling menghormati demi tercapainya tujuan pendidikan nasional.
In vivo and ex vivo impact of nutritional xenobiotics – acrylamide and sodium nitrates – on plasma antioxidant properties
Authors: Rorbach-Dolata Anna , Żurawska-Płaksej Ewa , Marchewka Zofia , Piwowar Agnieszka 
Published: August 2019

WstępGrupy tiolowe (SH) obecne w osoczu krwi odgrywają ważną rolę w oksydacyjno-antyoksydacyjnej homeostazie organizmu. Są one podatne na niekorzystne działanie różnych czynników egzo- i endogennych. Szczególnie istotnym problemem jest długotrwałe narażenie na różne ksenobiotyki, np. związki zawierające azot, powszechnie występujące w żywności. Celem naszych badań była ocena wpływu akrylamidu (<i>acrylamide</i> – ACR) i azotanu sodu (<i>sodium nitrate</i> – SN) – (V) i (III) – na właściwości przeciwutleniające osocza poprzez pomiar stężenia grup SH.Materiał i metodyStężenie grup SH w osoczu uzyskanym od 62 młodych osób (model in vivo; czas t<sub>0</sub>) oraz w próbkach poddanych godzinnej inkubacji z odpowiednim stężeniem ACR i SN (III) (model ex vivo; czas t<sub>1</sub>) mierzono metodą Ellmana. Stężenia ACR i SN (III) w modelu ex vivo odpowiadały ich dziennemu spożyciu (odpowiednio DIA – <i>daily intake of acrylamide</i> – i DIN – <i>daily intake of sodium nitrates</i> (V) i (III)), oszacowanemu na podstawie kwestionariusza żywieniowego.WynikiW obu modelach akrylamid i azotany spowodowały znaczny spadek stężenia grup SH, ale ACR spowodował silniejsze zmiany. Kobiety spożywały większą ilość związków zawierających azot w porównaniu z mężczyznami, prawdopodobnie z powodu odmiennych nawyków żywieniowych.WnioskiUzyskane wyniki wskazują, że ksenobiotyki zawierające azot są ważnymi czynnikami obniżającymi potencjał antyoksydacyjny osocza, a ich spożycie powinno być kontrolowane.
PENGARUH METODE PEMBELAJARAN BRAINSTORMING TERHADAP KETERAMPILAN BERPIKIR KREATIF PADA MATERI VIRUS KELAS X DI SMA NEGERI 1 PLAKAT TINGGI
Authors: Riswanda Jhon , Nawawi Sulton , Setiawan Dadang 
Published: August 2019

This study aims to determine the effect of Brainstorming learning method influence on creative thinking skills on Class X Virus material in SMA N 1 Plakat Tinggi MUBA Regency. This research uses the design of Nonequivalent Control Group Design research with Quasi Experiment method. The sample of this research is 78 students. Based on the results of data analysis students' creative thinking skills show that the implementation of learning using Brainstorming learning method is better than conventional methods. This can be seen from the calculation of t-test sig titung 0.000 < 0.005, then Ha accepted and Ho rejected. The result of analysis of the average increase of mastery of experimental creative thinking skill is 87.4% while the students 'thinking skill in the control class is 77.4% meaning that the students' creative thinking skill is higher than the creative thinking skill of the control class. So, it can be concluded that the method of Brainstorming influence the creative thinking skills of students class X MIPA SMA N1 Plakat Tinggi MUBA regency.
Pengembangan Multimedia Interaktif Pengenalan Salat untuk Meningkatkan Aspek Perkembangan Anak Usia Dini
Authors: Marlisa Lusi , Purnama Sigit 
Published: August 2019

<p>The aims of the reaserch was: (1) to know how the development of interactive multimedia in praying introduction; (2) to know the effectiveness of the use of interactive multimedia the introduction of prayer for aspects of child development in integrated isamic kindergarten Mutiara Banguntapan, Bantul Yogyakarta. The method that used in this research was Research and Development (R&amp;D) R&amp;D used for measuring the feasibility of interactive multimedia product by refering to development style of Borg &amp; Gall through 6 stages of development, namely: (1) potential and problem; (2) data collection; (3) design product; (4) validation product; (5) revision product; (6) trials product. The result of the research showed that: (1) interactive multimedia of prayer introduction was developed based on the development prosedure Borg and Gall. The appropriateness of product based on the validation of media experts and material experts with an overall rating of 3.83 in the good category. So that, can be concluded that multimedia developed was suitable to use in the learning media of prayer introduction, then; (2) Application of multimedia interactive prayer performed on 15 child in the class A2 abu sufyan bin harist, by conducting experimental trials by looking at the effectiveness of the use of interactive multimedia introduction of pre and post prayers on aspects of child development. Average effectiveness before use interactive multimedia introduction prayer on aspects child development 36,54% and Average effectiveness after use interactive multimedia introduction prayer on aspects child development 76,66% with motoric physical development 73,33%, language 80%, cognitive 80%, social emotional 73,33%. So it can be concluded that by using interactive multimedia the introduction of prayer to aspects of development is more effective than not using interactive multimedia recognition of prayer on aspects of development.</p>
Pneumococcal serotypes in children and relationship with clinical presentation and antimicrobial susceptibility in the PCV13 era
Authors: Izquierdo Conchita , Ciruela Pilar , Hernandez Sergi , García Juan Jose , Esteve Cristina , Moraga Fernando , Diaz Alvaro , Osorio Johanna Martínez - , Solé-Ribalta Anna , Sevilla Mariona Fernandez de , Gonzàlez-Peris Sebastian , Codina Gemma , Planes Anna Maria , Uriona Sonia , Campins Magda , Muñoz Carmen , Salleras Lluis , Domínguez Angela 
Published: August 2019

Abstract
Background: The aim of this study was to analyse the serotypes causing invasive pneumococcal disease (IPD) according to the clinical presentation, and antimicrobial susceptibility in children aged ≤17 years before the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in the official paediatric schedule.
Methods: We conducted a prospective study in children ≤17 years with IPD attended in three Catalan hospitals between January 2012 and June 2016. IPD cases were diagnosed by culture or RT-PCR. Demographic, microbiological, and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI).
Results: Of the 253 cases included, 34.4% were aged < 2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% of cases were PCV13 serotypes. Cases with PCV13 serotypes were associated with overall pneumonia (OR:7.47[4.0-13.96]) and complicated pneumonia (OR:7.2[4.04-12.75]), overall and in each age group (p<0.05). Serotypes 3 and 1 were associated with complicated pneumonia (p<0.05). Non-PCV13 serotypes were associated with meningitis (OR:7.32[2.33-22. 99]) and occult bacteremia (OR:3.6[1.56-8.76]). Serotype 19A was more frequent in children aged <2 years and serotype 3 and 1 in those aged 2-4 years and >4 years, respectively. Forty-four cases (36.1%) were non-susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. There were no significant differences between PCV13 and non-PCV13 cases with non-susceptible penicillin strains (36.1% and 36.0%, respectively), while PCV13 cases showed more frequently non-susceptible cefotaxime strains (23.6%; p=0.010). Serotypes 19A and 14 were associated with non-susceptibility to both penicillin and cefotaxime strains (p=0.003 and p<0.001, respectively) and serotype 19A with resistant to penicillin (p=0.002)
Conclusions: PCV13 serotypes were the most frequent serotypes in children aged ≤17years, mainly serotype 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia while PCV13 serotypes with pneumonia. PCV13 and non-PCV13 cases presented high frequency of non-susceptibility to penicillin. Serotypes 19A, and 14 were associated with non-susceptibility to both penicillin and cefotaxime, and serotype19A with penicillin resistance.
Transcriptome analysis provides insights into the non-methylated lignin synthesis in Paphiopedilum armeniacum seed
Authors: fang lin , Xu Xin , Li Ji , Zheng Feng , Li Mingzhi , Yan Jingwei , Li Yuan , Zhang Xinhua , Li Lin , Ma Guohua , Zhang Aying , Lv Fubin , Wu Kunlin , Zeng Songjun 
Published: August 2019

Abstract
Abstract

Backgrounds
Paphiopedilum is an important genus of orchid family (Orchidaceae) with high horticultural value. The wild populations are under the threat of extinction because of over collection and habitat destruction. Mature seeds of most Paphiopedilum species are difficult to germinate, which severely restricts the germplasm resources protection and commercial production. The germination inhibition factors are largely unknown.
Results
In this study, we found large amounts of non-methylated lignin were accumulated during seed maturation of Paphiopedilum armeniacum (P. armeniacum), which negatively correlates with the germination rate. We then further compared the transcriptome profiles of P. armeniacum seed at different development stages to explore molecular clues for the non-methylated lignin synthesis. KEGG enrichment analysis showed that a large number of genes associated with phenylpropanoid biosynthesis and phenylalanine metabolism as the seed maturation were differentially expressed. Several key genes in the lignin biosynthetic pathways displayed different expression patterns during the lignification process. PAL, 4CL, HCT and CSE were up-regulated to accelerate the C and H lignin accumulation. The expression of CCoAOMT, F5H and COMT were maintained at a low level or down-regulated to inhibit the conversion to the typical G and S lignin. Quantitative real-time RT-PCR analysis confirmed the altered expression levels of these genes among seeds and vegetative tissues.
Conclusions
This work demonstrated the plasticity of natural lignin polymer assembly in seed, and provided a better understanding of the molecular mechanism of seed-specific lignification process.
Investigation and Analysis of Standardized Training for Residents of General Practitioners of Gansu Province in China
Authors: Cai Hui , Wang Hongjing , He Jin , Zhang Dongzhi , Wu Yue , Wang Peidong 
Published: August 2019

Abstract
Background: China’s standardized training for residents of general practitioners (GPs) is aimed at providing the postgraduate training to family physicians who will serve the primary medicine units. The aim of this paper is to investigate the standardized training situation, satisfaction of standardized training, work situation and intention, satisfaction of work and attitude for GPs who have finished standardized training.
Methods: This study was undertaken among 6 training hospitals of Gansu province. The survey included a questionnaire with 73 queries.
Results: Approximately 275 residents of GPs were approached. In total, 263 residents participated (95.64% response rate). The average age of the participants was 28 years (standard deviation, 1.93 years; range, 25-36 years). The gender distribution was 50.57% women and 49.43% men. Marital status was 56.65% single and 43.35% married. In the results, 92.40% residents had obtained certification of the standardized training for residents of GPs. Only 39.54% residents were satisfied for monthly income during the training. And among 171 rural medical oriented graduates, only 42.69% residents wanted to continue to work at the grass-roots level when the serve time 6 years was finished. 86.31% residents of GPs who had finished the standardized training had jobs. More than half of medical institutions were belong to the primary medical and health institutions. Only 29.96% residents were registered as GPs. And the main reason for not been registered as GPs was that the medical institutions and sanitary bureau did not know the general medicine policy and did not agree. Among the residents who were assigned in general practice department, 68.42% of the work was diagnosis and treatment of common disease and frequently-occurring diseases and the referral of patients. The percentage of residents who were satisfied for the job and income were 30.40% and 14.98% respectively.
Conclusion: China’s standardized training for residents of GPs is under gradual improvement and development. In order to cultivate more GPs and let more GPs be willing to serve the grass-roots level, formulating and executing more good policy for GPs and increasing the publicity of general medicine and GPs are necessary.