bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Two Thrombin Generation Methods, CAT and ST-Genesia, in Liver Transplant Patients
Authors: Roullet Stéphanie , Labrouche Sylvie , Freyburger Geneviève 
Published: April 2019

Background During liver transplantation (LT), thrombin generation (TG) is altered. The most frequently used assay for TG is the Calibrated Automated Thrombogram (CAT). It is designed for series of plasmas and is semi-automated. Complete automation has led to a new device, the ST-Genesia, enabling quantitative standardized TG evaluation.
Objective The aim of this observational study was to compare the TG results of the CAT and the ST-Genesia on frozen-thawed plasma samples prepared from the blood of LT patients.
Patients and Methods Poor platelet plasma aliquots were prepared from blood samples from six LT patients selected to get the whole range of TG and were assessed with CAT (recombinant human tissue factor [TF] concentration 5 pm) and with ST-Genesia Bleedscreen assay (BS, using ‘low’ recombinant human TF concentration) and Thromboscreen assay (TS, using ‘medium’ recombinant human TF concentration). The TG parameters studied were: lag time, peak, time to peak, endogenous thrombin potential, velocity index and start tail.
Results BS and TS did not differ significantly from each other whatever the parameter studied, whereas most of the CAT parameters were significantly different from those obtained with BS and TS. Hierarchical clustering analysis of the different parameters of TG showed three homogeneous groups. One cluster gathered TG quantitative parameters from ST-Genesia. A second cluster gathered all the kinetic parameters. The last cluster isolated the quantitative parameters of CAT.
Conclusion In patients undergoing LT, TG performed with CAT and with ST-Genesia provided different results, for unknown reasons.
Phenotypic Variation between Monochorionic Diamniotic Twins with Coffin–Siris Syndrome
Authors: LaBrecque Brett , Contreras Marioxy , Giordano Jessica , Parravicini Elvira 
Published: April 2019

AbstractThe first known documented case of monochorionic–diamniotic twins with Coffin–Siris syndrome is described in this study. This case is notable because of the phenotypic differences between infants despite having identical genomes and causative variants. Also unique to this case is the clinical influence of early diagnosis using precision medicine techniques.
Excessive Seizure Clusters in an Otherwise Well-Controlled Epilepsy as a Possible Hallmark of Untreated Vitamin B6-Responsive Epilepsy due to a Homozygous PLPBP Missense Variant
Authors: Johannsen Jessika , Bierhals Tatjana , Deindl Philipp , Hecher Laura , Hermann Katharina , Hempel Maja , Kloth Katja , Denecke Jonas 
Published: April 2019

AbstractRecently, mutations in the PLPBP gene were described as a novel cause for vitamin B6-responsive epilepsy. We report the outcome in case of a male adolescent with a novel homozygous missense variant in PLPBP who was never treated with pyridoxine until the age of 16 years. He presented with only mild cognitive impairment and an early-onset, well-controlled epilepsy. In our patient, excessive seizure clusters and anxiety states occurred intermittently, suggesting that the combination might be a hallmark in untreated patients. Thus, mutations in PLPBP should be addressed even in adolescent patients with only mild learning disabilities and relatively good seizure control over the years.
Signatures of slip in dewetting polymer films
Authors: Peschka Dirk , Haefner Sabrina , Marquant Ludovic , Jacobs Karin , Münch Andreas , Wagner Barbara 
Published: April 2019

Significance
Dewetting is the hydrodynamic process where a uniform layer of liquid destabilizes and decays into distinct patterns of stationary droplets by virtue of interfacial and intermolecular energies. These patterns can now be predicted theoretically, and their evolution can be followed numerically in striking similarity to experimental results. The droplet arrays observed during the quasistatic evolution are generated by two distinct types of instabilities: droplet shedding of moving liquid rims and satellite droplet pinch-off during the decay of stationary ridges. The mechanism causing the emergence of different droplet patterns is the dissipation at the liquid–solid interface modeled by an effective Navier slip.
Our Everyday Aesthetic Evaluations of Architecture
Authors: Franco Abel B 
Published: April 2019

Abstract
I argue that our everyday evaluations of architecture are primarily evaluations of spaces and, in particular, of their inhabitability— that is, whether they serve or can serve to the realization of our individual ideal of life. Inhabitability is not only a functional criterion but an aesthetic one as well. It is aesthetic insofar as the evaluations about inhabitability include evaluations about the quality of the experience of actually doing something in —or simply occupying—a particular space. This aesthetic aspect of our everyday evaluations explains, on one hand, the distinctive features of our everyday preferences for some architectonic spaces over others—namely, (a) their very personal nature; (b) their noticeable value in our daily lives; (c) their inseparability from the activities we plan to realize in those spaces; and (d) the importance of the spaces which are contiguous to the one we are evaluating. And on the other, it both reveals architecture’s significance for the quality of our daily life and serves as a guide for us to choose spaces that improve that quality.
Optimal Target Blood Pressure and Risk of Cardiovascular Disease in Low-Risk Younger Hypertensive Patients
Authors: Kwon Chang Hee , Kang Jeonggyu , Cho Ara , Chang Yoosoo , Ryu Seungho , Sung Ki-Chul 
Published: April 2019

Abstract

BACKGROUND
This study aimed to examine longitudinal associations between blood pressure (BP) categories and incident cardiovascular disease (CVD) in treated hypertensive patients without CVD.

METHODS
A cohort study was performed in Korean adults who underwent a comprehensive health examination from 1 January 2011 to 31 December 2016 and was followed for incident CVD via linkage to the Health Insurance and Review Agency database until the end of 2016, with a median follow-up of 4.3 years.

RESULTS
Among 263,532 participants, 8,418 treated hypertensive patients free of CVD at baseline were included. The incident CVD end point was defined as new hospitalization for CVD, including ischemic heart disease, stroke, and transient ischemic attack. During 32,975.6 person-years of follow-up, 200 participants developed new-onset CVD (incidence rate of 60.6 per 104 person-years). The multivariable-adjusted hazard ratio (HR; 95% confidence intervals [CI]) for CVD according to systolic blood pressure (SBP) levels (comparing SBP < 110, SBP = 120–129, SBP = 130–139, SBP = 140–149, SBP = 150–159, and SBP ≥160 to SBP 110–119 mm Hg [reference]) were 0.83 (0.53–1.30), 1.31 (0.91–1.89), 1.18 (0.74–1.87), 1.46 (0.79–2.72), 3.19 (1.25–8.12), and 5.60 (2.00–15.70), respectively. In multivariable analysis for CVD according to diastolic blood pressure (DBP) levels, HR (95% CI) of DBP < 60, DBP = 70–79, DBP = 80–89, DBP = 90–99, and DBP ≥100 compared to DBP = 60–69 mm Hg [reference]) were 0.51 (0.12–2.14), 1.13 (0.76–1.67), 1.26 (0.83–1.92), 1.62 (0.89–2.97), and 1.68 (0.51–5.55), respectively.

CONCLUSIONS
In this large cohort of middle-aged treated hypertensive patients, SBP < 120 mm Hg and/or DBP < 70 mm Hg were acceptable and showed a trend of protection of incident CVD.
Convergence to the tiniest detail: vocal sac structure in torrent-dwelling frogs
Authors: Elias-Costa Agustín J , Faivovich Julián 
Published: April 2019

Abstract
Cascades and fast-flowing streams impose severe restrictions on acoustic communication, with loud broadband background noise hampering signal detection and recognition. In this context, diverse behavioural features, such as ultrasound production and visual displays, have arisen in the evolutionary history of torrent-dwelling amphibians. The importance of the vocal sac in multimodal communication is being increasingly recognized, and recently a new vocal sac visual display has been discovered: unilateral inflation of paired vocal sacs. In the diurnal stream-breeding Hylodidae from the Atlantic forest, where it was first described, this behaviour is likely to be enabled by a unique anatomical configuration of the vocal sacs. To assess whether other taxa share this exceptional structure, we surveyed torrent-dwelling species with paired vocal sacs across the anuran tree of life and examined the vocal sac anatomy of exemplar species across 18 families. We found striking anatomical convergence among hylodids and species of the distantly related basal ranid genera Staurois, Huia, Meristogenys and Amolops. Ancestral character state reconstruction identified three new synapomorphies for Ranidae. Furthermore, we surveyed the vocal sac configuration of other anuran species that perform visual displays and report observations on what appears to be unilateral inflation of paired vocal sacs, in Staurois guttatus – an extremely rare behaviour in anurans.
Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice†
Authors: Mu Yang , Yin Tai-lang , Huang Xiao-xuan , Hu Xue , Yin Lu , Yang Jing 
Published: April 2019

Abstract
Sulforaphane (SFN), a dietary isothiocyanate that is mainly found in cruciferous vegetables, possesses anti-oxidative and anticancer activity and modulates inflammation. However, little is known about the role of SFN in obesity-related male reproductive defects. The present study aimed to investigate the effects of SFN on high-fat diet (HFD)-induced male spermatogenic impairment and further clarify the possible underlying mechanisms. In this study, 8-week-old mice were randomly divided into four groups. Mice were fed a normal diet or an HFD with or without SFN supplementation. Sulforaphane was subcutaneously injected at a dose of 0.5 mg/kg 5 days/week for 4 weeks beginning 8 weeks after initiation of the HFD. The results demonstrated that SFN could protect against HFD-induced reproductive dysfunction in male mice. Moreover, SFN also improved reproductive ability, as demonstrated by an increased pregnancy rate and decreased embryo resorption rate in comparison to the corresponding HFD group. We also observed a decrease in apoptosis and an attenuation of endoplasmic reticulum (ER) stress after SFN treatment. In vitro studies of mouse and human sperm samples also revealed that SFN protects against the palmitic acid-induced reduction in sperm viability and motility by inhibiting ER stress in an AMP-activated protein kinase (AMPK)-dependent manner. AMPK-dependent ER stress attenuation by SFN was further confirmed using AMPK knockout mice. Taken together, these data show that SFN protects against HFD-induced male reproductive dysfunction by inhibiting ER stress and apoptosis. These findings may be helpful for identifying new therapeutic methods to treat male infertility.
Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study
Authors: Hsu Raymond K , Hsu Chi-yuan , McCulloch Charles E , Yang Jingrong , Anderson Amanda H , Chen Jing , Feldman Harold I , He Jiang , Liu Kathleen D , Navaneethan Sankar D , Porter Anna C , Rahman Mahboob , Tan Thida C , Wilson F Perry , Xie Dawei , Zhang Xiaoming , Go Alan S ,   Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Appel Lawrence J , Kusek John W , Lash James P , Rao Panduranga S , Townsend Raymond R 
Published: April 2019

AbstractBackgroundObservational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI.MethodsWe studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. Models were adjusted for demographic characteristics, diabetes status and albuminuria.ResultsDuring median follow-up of 8.5 years, mean rate of eGFR loss was −0.31 mL/min/1.73 m2/year overall, and 73 individuals experienced AKI (55% Stage 1). A significant interaction existed between AKI and source of serum creatinine for acute absolute change in eGFR level after discharge; in contrast, AKI was independently associated with a faster rate of eGFR decline (mean additional loss of −0.67 mL/min/1.73 m2/year), which was not impacted by source of serum creatinine.ConclusionsAKI is independently associated with subsequent steeper eGFR decline regardless of the serum creatinine source used, but the strength of association is smaller than observed in prior studies after taking into account key confounders such as pre-AKI eGFR slope and albuminuria.
Psychological Distress in Bullied Deaf and Hard of Hearing Adolescents
Authors: Cheng An-Wen , Chou Yu-Ching , Lin Fu-Gong 
Published: April 2019

AbstractBullying victimization at school is an important concern in terms of mental health, in particular, for deaf and hard of hearing (DHH) adolescents who may be more vulnerable than hearing peers. This study determined the prevalence of bullying victimization among DHH adolescents in Taiwan and ascertained the relation of bullying victimization experiences and family and school variables with their psychological well-being. Data were collected from the 2011 Special Needs Education Longitudinal Study database. Multivariate regression analysis was performed on variables comprising seven items measuring psychological distress; four types of bullying victimizations; and family-, school-, and peer-related factors. Approximately 65% of DHH adolescents experienced at least one type of bullying victimization. Factors such as exclusion bullying, female gender, delayed bedtime, conflicts with parents, unfavorable relationship with parents, inability to get along with friends, dislike for school, and bullying victimization experiences increased psychological distress in the DHH adolescents. Bullying victimization of DHH adolescents is a risk factor for poor mental health. However, a good relationship of these adolescents with their parents and peers could be protective for their psychological well-being. Therefore, parents and teachers should understand the needs of DHH adolescents and establish antibullying strategies to diminish their mental health problems.
Pioneering International Women’s Rights? The US National Woman’s Party and the 1933 Montevideo Equal Rights Treaties
Authors: Amorosa Paolo 
Published: April 2019

Abstract
Histories of equal rights for women in international law normally begin with post-World War II initiatives. Such an approach leaves out two treaties signed at the 1933 Montevideo Pan-American Conference, the Equal Nationality Treaty and the Equal Rights Treaty, which remain forgotten among international lawyers. By reconstructing their inception and intellectual background, this article aims to raise awareness about debates on international law among feminist activists in the interwar years. In turn, the focus on activist work allows for the recovery of the contribution of women to the development of the discipline in that seminal period, a contribution usually obfuscated by men’s predominance in diplomatic and academic roles. By outlining the contribution of two key promoters of the Montevideo treaties – Doris Stevens and Alice Paul of the National Woman’s Party – the article takes a step towards the re-inclusion of women’s rights activists within the shared heritage of international law and its history.
Why Do the Affluent Find Inequality Increasingly Unjust? Changing Inequality and Justice Perceptions in Germany, 1994–2014
Authors: Sachweh Patrick , Sthamer Evelyn 
Published: April 2019

AbstractIn the wake of rising inequality in Germany during the last 20 years, we document a corresponding increase in perceptions of injustice among the population. Based on data from the cumulated German General Social Survey (ALLBUS), we show that this increase in perceived injustice is driven mainly by a rising share of affluent respondents who find society unjust, resulting in a convergence across income groups towards more critical attitudes. We try to explain this puzzling development based on outcome-related justice assessments and perceptions of procedural justice. We find that outcome-related justice assessments cannot explain the trend over time, but affect the overall level of injustice perceptions. The influence of perceptions of procedural justice, however, is more pronounced among affluent respondents and partly explains the increase in injustice perceptions within this group. These results are robust for different operationalizations as well as model specifications and are not due to compositional effects. Since we cannot account entirely for the rise in injustice perceptions among the affluent, explanatory factors not covered by our data are likely to exist. We conclude with a discussion of potential explanations that future research should address.
Surgical obesity treatment and the risk of heart failure
Authors: Jamaly Shabbar , Carlsson Lena , Peltonen Markku , Jacobson Peter , Karason Kristjan 
Published: April 2019

Abstract

Aims
Obesity is associated with increased risk for heart failure. We analysed data from the Swedish Obese Subjects (SOS) study, a prospective matched cohort study, to investigate whether bariatric surgery reduces this risk.

Methods and results
From the total SOS population (n = 4047), we identified 4033 obese individuals with no history of heart failure at baseline, of whom 2003 underwent bariatric surgery (surgery group) and 2030 received usual care (control group). First-time principal diagnoses of heart failure were identified by crosschecking the SOS database with the Swedish National Patient Register and the Swedish Cause of Death Register using diagnosis codes. During a median follow-up of 22 years, first-time heart failure occurred in 188 of the participants treated with surgery and in 266 of those receiving usual care. The risk of developing heart failure was lower in the surgery group than in the control group [sub-hazard ratio 0.65, 95% confidence interval (CI) 0.54–0.79; P &lt; 0.001]. After pooling data from the two study groups, the quartile of subjects with the largest weight loss after 1 year (mean −41 kg) displayed the greatest risk reduction (sub-hazard ratio 0.51, 95% CI 0.30–0.70; P &lt; 0.001). This association remained statistically significant after adjustment for surgical intervention and potential baseline confounders (sub-hazard ratio 0.60, 95% CI 0.36–0.97; P = 0.038).

Conclusion
Compared with usual care, bariatric surgery was associated with reduced risk of heart failure among persons being treated for obesity. The risk of heart failure appeared to decline in parallel with a greater degree of weight loss.

ClinicalTrials.gov Identifier
NCT01479452.
The endometrial immune environment of women with endometriosis
Authors: Vallvé-Juanico Júlia , Houshdaran Sahar , Giudice Linda C 
Published: April 2019

AbstractBACKGROUNDEndometriosis, a common oestrogen-dependent inflammatory disorder in women of reproductive age, is characterized by endometrial-like tissue outside its normal location in the uterus, which causes pelvic scarring, pain and infertility. While its pathogenesis is poorly understood, the immune system (systemically and locally in endometrium, pelvic endometriotic lesions and peritoneal fluid) is believed to play a central role in its aetiology, pathophysiology and associated morbidities of pain, infertility and poor pregnancy outcomes. However, immune cell populations within the endometrium of women with the disease have had incomplete phenotyping, thereby limiting insight into their roles in this disorder.OBJECTIVE AND RATIONALEThe objective herein was to determine reproducible and consistent findings regarding specific immune cell populations and their abundance, steroid hormone responsiveness, functionality, activation states, and markers, locally and systemically in women with and without endometriosis.SEARCH METHODSA comprehensive English language PubMed, Medline and Google Scholar search was conducted with key search terms that included endometriosis, inflammation, human eutopic/ectopic endometrium, immune cells, immune population, immune system, macrophages, dendritic cells (DC), natural killer cells, mast cells, eosinophils, neutrophils, B cells and T cells.OUTCOMESIn women with endometriosis compared to those without endometriosis, some endometrial immune cells display similar cycle-phase variation, whereas macrophages (Mø), immature DC and regulatory T cells behave differently. A pro-inflammatory Mø1 phenotype versus anti-inflammatory Mø2 phenotype predominates and natural killer cells display abnormal activity in endometrium of women with the disease. Conflicting data largely derive from small studies, variably defined hormonal milieu and different experimental approaches and technologies.WIDER IMPLICATIONSPhenotyping immune cell subtypes is essential to determine the role of the endometrial immune niche in pregnancy and endometrial homeostasis normally and in women with poor reproductive history and can facilitate development of innovative diagnostics and therapeutics for associated symptoms and compromised reproductive outcomes.
Getting more from heterogeneous HIV-1 surveillance data in a high immigration country: estimation of incidence and undiagnosed population size using multiple biomarkers
Authors: Giardina Federica , Romero-Severson Ethan O , Axelsson Maria , Svedhem Veronica , Leitner Thomas , Britton Tom , Albert Jan 
Published: April 2019

AbstractBackgroundMost HIV infections originate from individuals who are undiagnosed and unaware of their infection. Estimation of this quantity from surveillance data is hard because there is incomplete knowledge about (i) the time between infection and diagnosis (TI) for the general population, and (ii) the time between immigration and diagnosis for foreign-born persons.MethodsWe developed a new statistical method for estimating the incidence of HIV-1 and the number of undiagnosed people living with HIV (PLHIV), based on dynamic modelling of heterogeneous HIV-1 surveillance data. The methods consist of a Bayesian non-linear mixed effects model using multiple biomarkers to estimate TI of HIV-1-positive individuals, and a novel incidence estimator which distinguishes between endogenous and exogenous infections by modelling explicitly the probability that a foreign-born person was infected either before or after immigration. The incidence estimator allows for direct calculation of the number of undiagnosed persons. The new methodology is illustrated combining heterogeneous surveillance data from Sweden between 2003 and 2015.ResultsA leave-one-out cross-validation study showed that the multiple-biomarker model was more accurate than single biomarkers (mean absolute error 1.01 vs ≥1.95). We estimate that 816 [95% credible interval (CI) 775-865] PLHIV were undiagnosed in 2015, representing a proportion of 10.8% (95% CI 10.3-11.4%) of all PLHIV.ConclusionsThe proposed methodology will enhance the utility of standard surveillance data streams and will be useful to monitor progress towards and compliance with the 90–90-90 UNAIDS target.