bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the predictive ability of a commercial artificial intelligence early warning system with physician judgement for clinical deterioration in hospitalised general internal medicine patients: a prospective observational study
Authors: Arnold Jonathan , Davis Alex , Fischhoff Baruch , Yecies Emmanuelle , Grace Jon , Klobuka Andrew , Mohan Deepika , Hanmer Janel 
Published: October 2019

ObjectiveOur study compares physician judgement with an automated early warning system (EWS) for predicting clinical deterioration of hospitalised general internal medicine patients.DesignProspective observational study of clinical predictions made at the end of the daytime work-shift for an academic general internal medicine floor team compared with the risk assessment from an automated EWS collected at the same time.SettingInternal medicine teaching wards at a single tertiary care academic medical centre in the USA.ParticipantsIntern physicians working on the internal medicine wards and an automated EWS (Rothman Index by PeraHealth).OutcomeClinical deterioration within 24 hours including cardiac or pulmonary arrest, rapid response team activation or unscheduled intensive care unit transfer.ResultsWe collected predictions for 1874 patient days and saw 35 clinical deteriorations (1.9%). The area under the receiver operating curve (AUROC) for the EWS was 0.73 vs 0.70 for physicians (p=0.571). A linear regression model combining physician and EWS predictions had an AUROC of 0.75, outperforming physicians (p=0.016) and the EWS (p=0.05).ConclusionsThere is no significant difference in the performance of the EWS and physicians in predicting clinical deterioration at 24 hours on an inpatient general medicine ward. A combined model outperformed either alone. The EWS and physicians identify partially overlapping sets of at-risk patients suggesting they rely on different cues or decision rules for their predictions.Trial registration numberNCT02648828.
Acute interventions for aggression and agitation in psychosis: study protocol for a systematic review and network meta-analysis
Authors: Ostinelli Edoardo G , D’Agostino Armando , Shokraneh Farhad , Salanti Georgia , Furukawa Toshi A 
Published: October 2019

IntroductionIndividuals with psychosis may access emergency services due to aggression and agitation. When the de-escalation technique fails to achieve tranquillisation, several pharmacological options are available. However, evidence on which intervention to prefer in terms of efficacy and tolerability to achieve resolution of the acute episode (ie, rapid tranquillisation) of aggression and agitation is currently fragmentary.Methods and analysisWe will include all randomised controlled trials comparing drugs or drug combinations or placebo for aggression or agitation episodes in adult individuals with psychosis. We will include individuals with psychosis (eg, schizophrenia and related disorders, bipolar disorder with psychotic symptoms, psychotic depression) but not substance or medication-induced psychosis or psychosis due to another medical condition. Our primary outcomes are the change in aggression or agitation scores within few hours since the administration of the intervention (efficacy outcome) and the proportion of participants who dropped out due to adverse effects (tolerability outcome). We will retrieve relevant studies from the register of studies of the Cochrane Schizophrenia Group. Also, we will run additional searches on CENTRAL, Embase and PubMed to retrieve potentially eligible studies focusing on other psychiatric diagnoses than those in the schizophrenia spectrum. We will conduct a random-effects network meta-analysis (NMA) for primary and secondary outcomes. In case of rare events of dichotomous outcomes, a common-effect Mantel-Haenszel NMA will be used instead. We will use the surface under the cumulative ranking curve and the mean ranks to rank all available treatments. Local and global methods of evaluation of inconsistency will be employed. Quality of evidence contributing to network estimates of the main outcomes will also be assessed with Confidence in Network Meta-Analysis.Ethics and disseminationThis study does not require ethical approval. We will disseminate our findings by publishing results in a peer-reviewed journal.PROSPERO registration numberCRD42019137945.
Interventions for improving teamwork in intrapartum care: a systematic review of randomised controlled trials
Authors: Wu Michael , Tang Jennifer , Etherington Cole , Walker Mark , Boet Sylvain 
Published: October 2019

BackgroundThe labour and delivery environment relies heavily on interdisciplinary collaboration from anaesthesiologists, obstetricians and nurses or midwives to deliver optimal patient care. A large number of adverse events in obstetrics are associated with failure in communication and teamwork among team members, with substantive consequences. The objective of this study is to perform a systematic review of interventions aimed at improving teamwork in obstetrics.MethodsThis systematic review identified and assessed randomised controlled trials (RCTs) of interventions aimed at improving teamwork among interdisciplinary teams in obstetrical care. Medline, CENTRAL, CINAHL and Embase were searched for studies evaluating one of: patient outcomes, team performance or processes of clinical efficiency. Identified citations were reviewed in duplicate for eligibility.ResultsNine RCTs met the inclusion criteria; five of these RCTs were conducted under simulated clinical environments. Simulation-based teamwork training interventions were the most represented (n=7 studies, 3047 healthcare providers (HCPs), 107 782 births), followed by checklists (n=1 study, 136 HCPs) and an electronic-based decision support tool (n=1 study, 296 HCPs). Simulation-based teamwork training was found to improve team performance in 100% of relevant studies (3 of 3 studies assessing team performance) and patient morbidity in 75% of relevant studies (3 of 4 studies assessing patient morbidity). However, no direct mortality benefit was identified among all the studies reviewed. Studies were assessed to be of low-moderate quality and had significant limitations in their study designs.ConclusionWhile the evidence is still limited and from low to moderate quality RCTs, simulation-based teamwork interventions appear to improve team performance and patient morbidity in labour and delivery care.PROSPERO Trial registration numberCRD42018090452
Clinical effectiveness of cognitive behavioural therapy on alcohol-dependent patients: an observation with the WeChat platform
Authors: Chen Jing , Qian Mincai , Sun Conghao , Lin Min , Tang Weili 
Published: October 2019

BackgroundWith the continuous improvement of people’s material living standards, the consumption of alcoholic beverages is increasing. Alcohol dependence caused by alcohol addiction has become a widespread concern in society. As the brand-new medical and health model created by the modern biomedical technology revolution and the information technology revolution, mobile health has been used more and more widely in the field of medical health with the characteristics of convenience, rapidity and generalisability. With the general use of the social software WeChat, it is feasible to implement mobile health on the WeChat platform.AimWe aimed to explore the clinical effect of WeChat platform used in the cognitive behavioural therapy (CBT) on the maintenance period of alcohol dependence and addiction.MethodsSeventy alcohol-dependent patients in the withdrawal maintenance stage admitted into our hospital were randomly divided into the CBT on WeChat platform group (the experiment group, n=35) and the general clinical treatment using sertraline group (the control group, n=35) with block randomisation grouping. They were evaluated with the Severity of Alcohol Dependence Questionnaire (SADQ-C) before the treatment, at the end of the fourth week, at the end of the eighth week and at the end of the twelfth week of treatment. In addition, Zung’s Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were employed to evaluate the degree of anxiety and depression of the two groups.ResultsThe SADQ-C, SAS and SDS scores of the two groups after treatment decreased markedly compared with those before treatments, and the differences were statistically significant. Between-group comparison: the SADQ-C scores of the experiment group at the end of the fourth, eighth and twelfth weeks were lower than those of the control group, and the difference was statistically significant, which indicated that the score reduction in the experiment group was larger than that in the control group. The SAS and SDS scores of the experiment group at these time points were not significantly different from those of the control group, which indicated that these two treatment methods were comparable in treating patients’ anxiety and depression.ConclusionThe CBT intervention using WeChat may improve the subjectively reported severity of alcohol dependence of patients who had completed detoxification. It is conducive to prevention of relapse, and is convenient for patients. It is worthy of clinical application and further study.
Investigating the holographic complexity in Einsteinian cubic gravity
Authors: Jiang Jie , Deng Banglin 
Published: October 2019

Abstract
In this paper, we investigate the holographic complexity of a small mass AdS black hole in Einsteinian cubic gravity by using the “complexity equals action” (CA) and “complexity equals volume” (CV) conjectures. In the CA context, the late-time growth rate satisfies the Lloyd bound for the $$k=0$$k=0 and $$k=1$$k=1 cases but it violates it for the $$k=-1$$k=-1 case in the first-order approximation of the small mass parameter. However, by a full-time analysis, we find that this late-time limit is approached from above, which implies that this bound in all of these cases will be violated. In the CV context, we considered both the original and the generalized CV conjectures. Differing from the CA conjecture, the late-time rate here is non-vanishing in the zeroth-order approximation, and this shows that the Lloyd bound is exactly violated even in the late-time limit. These results show numerous differences from the neutral case of the Einstein gravity in both the CA and the CV holographic contexts where all of their late-time results saturate the Lloyd bound. These differences illustrate the influence of the higher curvature correction in Einstein gravity.
Could galactic magnetic fields be generated by charged ultra-light boson dark matter?
Authors: Hernández Maribel , Avilez Ana A. , Matos Tonatiuh 
Published: October 2019

Abstract
We study the possibility that large-scale magnetic fields observed in galaxies could be produced by a dark matter halo made of charged ultra-light bosons, that arise as excitations of a complex scalar field described by the Klein–Gordon equation with local U(1) symmetry which introduces electromagnetic fields that minimally couple to the complex scalar current and act as dark virtual photons. These virtual photons have an unknown coupling constant with real virtual photons. We constrain the final interaction using the observed magnetic fields in galaxies. We use classical solutions of the Klein–Gordon–Maxwell system to describe the density profile of dark matter and magnetic fields in galaxies. We consider two cases assuming spherical and dipolar spatial symmetries. For the LSB spherical galaxy F563-V2, we test the sensitivity of the predicted rotation curves in the charged Scalar Field Dark Matter (cSFDM) model to variations of the electromagnetic coupling and using the Fisher matrix error estimator, we set a constraint over that coupling by requiring that theoretical rotation curves lay inside the $$1\sigma $$1σ confidence region of observational data. We find that cSFDM haloes generate magnetic fields of the order of $$\mu G$$μG and reproduce the observed rotation curves of F563-V2 if the ultra-light boson has a charge $$\sim <10^{-13}e$$∼<10-13e for the monopole-like density profile and $$\sim <10^{-14}e$$∼<10-14e for the dipole-like one.
Bottomonia production and polarization in the NRQCD with $$k_T$$-factorization. I: $$\Upsilon (3S)$$ and $$\chi _b(3P)$$ mesons
Authors: Abdulov N. A. , Lipatov A. V. 
Published: October 2019

AbstractThe$$\Upsilon (3S)$$Υ(3S)production and polarization at high energies is studied in the framework of$$k_T$$kT-factorization approach. Our consideration is based on the non-relativistic QCD formalism for bound states formation and off-shell production amplitudes for hard partonic subprocesses. The transverse momentum dependent (TMD, or unintegrated) gluon densities in a proton were derived from the Ciafaloni-Catani-Fiorani-Marchesini (CCFM) evolution equation as well as from the Kimber–Martin–Ryskin (KMR) prescription. Treating the non-perturbative color octet transitions in terms of the multipole radiation theory and taking into account feed-down contributions from radiative$$\chi _b(3P)$$χb(3P)decays, we extract the corresponding non-perturbative matrix elements for$$\Upsilon (3S)$$Υ(3S)and$$\chi _b(3P)$$χb(3P)mesons from a combined fit to$$\Upsilon (3S)$$Υ(3S)transverse momenta distributions measured by the CMS and ATLAS Collaborations at the LHC energies$$\sqrt{s} = 7$$s=7and 13 TeV and central rapidities. Then we apply the extracted values to describe the CDF and LHCb data on$$\Upsilon (3S)$$Υ(3S)production and to investigate the polarization parameters$$\lambda _\theta $$λθ,$$\lambda _\phi $$λϕand$$\lambda _{\theta \phi }$$λθϕ, which determine the$$\Upsilon (3S)$$Υ(3S)spin density matrix. Our predictions have a good agreement with the currently available data within the theoretical and experimental uncertainties.
Deriving Equations from Sensor Data Using Dimensional Function Synthesis
Authors: Wang Youchao , Willis Sam , Tsoutsouras Vasileios , Stanley-Marbell Phillip 
Published: October 2019

We present a new method for deriving functions that model the relationship between multiple signals in a physical system. The method, which we call
dimensional function synthesis
, applies to data streams where the dimensions of the signals are known. The method comprises two phases: a compile-time synthesis phase and a subsequent calibration using sensor data.

We implement dimensional function synthesis and use the implementation to demonstrate efficiently summarizing multi-modal sensor data for two physical systems using 90 laboratory experiments and 10 000 synthetic idealized measurements. We evaluate the performance of the compile-time phase of dimensional function synthesis as well as the calibration phase overhead, inference latency, and accuracy of the models our method generates.
The results show that our technique can generate models in less than 300 ms on average across all the physical systems we evaluated. When calibrated with sensor data, our models outperform traditional regression and neural network models in inference accuracy in all the cases we evaluated. In addition, our models perform better in training latency (over 8660× improvement) and required arithmetic operations in inference (over 34× improvement). These significant gains are largely the result of exploiting information on the physics of signals that has hitherto been ignored.
In-exercise vascular shear rate during acute continuous and interval exercise: impact on endothelial function and miR-21
Authors: Lyall Gemma Kate , Davies Matthew John , Ferguson Carrie , Porter Karen E. , Birch Karen M. 
Published: October 2019

Endothelial cell phenotype and endothelial function are regulated by hemodynamic forces, particularly wall shear stress (WSS). During a single bout of exercise, the specific exercise protocol can affect in-exercise WSS patterns and, consequently, endothelial function. MicroRNAs might provide a biomarker of in-exercise WSS pattern to indicate whether a specific exercise bout will have a positive effect on endothelial function. We evaluated the effect of acute interval (IT) and continuous (CON) in-exercise WSS patterns upon postexercise endothelial function and circulating microRNA (miR)-21 expression. Methods and results: 13 participants performed CON and 3 different IT exercise protocols matched for duration and intensity on separate days. Oxygen uptake, heart rate, and brachial artery blood flow were recorded throughout the exercise. Brachial artery flow-mediated dilation (FMD) was performed pre-exercise and 15 min postexercise. Plasma samples were acquired pre-exercise and 6 h postexercise to determine miR-21 expression. In-exercise shear rate (SR) patterns (a surrogate of WSS) differed according to the CON or IT work-rate profile. In-exercise anterograde SR was greater in CON than IT exercise ( P < 0.05), but retrograde SR was equivalent between exercise protocols ( P > 0.05). Oscillatory shear index was higher during IT versus CON exercise ( P < 0.05). Postexercise FMD increased (pre: 7.08% ± 2.95%, post: 10.54% ± 4.24%, P < 0.05), whereas miR-21 expression was unchanged (pre: 12.0% ± 20.7% cel-miR-39, post: 11.1 ± 19.3% cel-miR-39, P > 0.05) with no effect of exercise protocol ( P > 0.05). Conclusions: CON and IT exercise induced different SR patterns but equivalent improvements in acute endothelial function. The absence of change in miR-21 expression suggests that miR-21 is not a suitable biomarker of exercise-induced SR. NEW & NOTEWORTHY Interval exercise has the potential to negatively impact vascular adaptations because of repeated oscillations in vascular shear. To our knowledge, we are the first to continuously assess exercise-induced shear throughout different acute exercise protocols and examine its relationship with acute endothelial function and a circulating biomarker of shear (miR-21). These experiments provide clear data indicating enhancement of the acute vascular response from differing interval exercise protocols, with the study also providing detailed vascular and shear responses for future reference.
Sleep disordered breathing induced by cervical spinal cord injury and effect of adenosine A1 receptors modulation in rats
Authors: Sankari Abdulghani , Minic Zeljka , Farshi Pershang , Shanidze Medea , Mansour Wafaa , Liu Fangchao , Mao Guangzhao , Goshgarian Harry G. 
Published: October 2019

Sleep-disordered breathing (SDB) is very common after spinal cord injury (SCI). The present study was designed to evaluate the therapeutic efficacy of adenosine A1 receptor blockade (8-cyclopentyl-1,3-dipropylxanthine, DPCPX) on SDB in a rodent model of SCI. We hypothesized that SCI induced via left hemisection of the second cervical segment (C2Hx) results in SDB. We further hypothesized that blockade of adenosine A1 receptors following C2Hx would reduce the severity of SDB. In the first experiment, adult male rats underwent left C2Hx or sham (laminectomy) surgery. Unrestrained whole body plethysmography (WBP) and implanted wireless electroencephalogram (EEG) were used for assessment of breathing during spontaneous sleep and for the scoring of respiratory events at the acute (~1 wk), and chronic (~6 wk) time points following C2Hx. During the second experiment, the effect of oral administration of adenosine A1 receptor antagonist (DPCPX, 3 times a day for 4 days) on SCI induced SDB was assessed. C2Hx animals exhibited a higher apnea-hypopnea index (AHI) compared with the sham group, respectively (35.5 ± 12.6 vs. 19.1 ± 2.1 events/h, P < 0.001). AHI was elevated 6 wk following C2Hx ( week 6, 32.0 ± 5.0 vs. week 1, 42.6 ± 11.8 events/h, respectively, P = 0.12). In contrast to placebo, oral administration of DPCPX significantly decreased AHI 4 days after the treatment (159.8 ± 26.7 vs. 69.5 ± 8.9%, P < 0.05). Cervical SCI is associated with the development of SDB in spontaneously breathing rats. Adenosine A1 blockade can serve as a therapeutic target for SDB induced by SCI. NEW & NOTEWORTHY The two key novel findings of our study included that 1) induced cervical spinal cord injury results in sleep-disordered breathing in adult rats, and 2) oral therapy with an adenosine A1 receptor blockade using DPCPX is sufficient to significantly reduce apnea-hypopnea index following induced cervical spinal cord injury.
HIMF (Hypoxia-Induced Mitogenic Factor) Signaling Mediates the HMGB1 (High Mobility Group Box 1)-Dependent Endothelial and Smooth Muscle Cell Crosstalk in Pulmonary Hypertension
Authors: Lin Qing , Fan Chunling , Gomez-Arroyo Jose , Van Raemdonck Katrien , Meuchel Lucas W. , Skinner John T. , Everett Allen D. , Fang Xia , Macdonald Andrew A. , Yamaji-Kegan Kazuyo , Johns Roger A. 
Published: October 2019

Objective:
HIMF (hypoxia-induced mitogenic factor; also known as FIZZ1 [found in inflammatory zone-1] or RELM [resistin-like molecule-α]) is an etiological factor of pulmonary hypertension (PH) in rodents, but its underlying mechanism is unclear. We investigated the immunomodulatory properties of HIMF signaling in PH pathogenesis.

Approach and Results:
Gene-modified mice that lacked HIMF (KO [knockout]) or overexpressed HIMF human homolog resistin (hResistin) were used for in vivo experiments. The pro-PH role of HIMF was verified in HIMF-KO mice exposed to chronic hypoxia or sugen/hypoxia. Mechanistically, HIMF/hResistin activation triggered the HMGB1 (high mobility group box 1) pathway and RAGE (receptor for advanced glycation end products) in pulmonary endothelial cells (ECs) of hypoxic mouse lungs in vivo and in human pulmonary microvascular ECs in vitro. Treatment with conditioned medium from hResistin-stimulated human pulmonary microvascular ECs induced an autophagic response, BMPR2 (bone morphogenetic protein receptor 2) defects, and subsequent apoptosis-resistant proliferation in human pulmonary artery (vascular) smooth muscle cells in an HMGB1-dependent manner. These effects were confirmed in ECs and smooth muscle cells isolated from pulmonary arteries of patients with idiopathic PH. HIMF/HMGB1/RAGE-mediated autophagy and BMPR2 impairment were also observed in pulmonary artery (vascular) smooth muscle cells of hypoxic mice, effects perhaps related to FoxO1 (forkhead box O1) dampening by HIMF. Experiments in EC-specific hResistin-overexpressing transgenic mice confirmed that EC-derived HMGB1 mediated the hResistin-driven pulmonary vascular remodeling and PH.

Conclusions:
In HIMF-induced PH, HMGB1-RAGE signaling is pivotal for mediating EC-smooth muscle cell crosstalk. The humanized mouse data further support clinical implications for the HIMF/HMGB1 signaling axis and indicate that hResistin and its downstream pathway may constitute targets for the development of novel anti-PH therapeutics in humans.