bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of metacognitive factors among patients with cancer and the control group
Authors: Mutlu Hasan Huseyin , Bilican F. Isil , Mutlu Hacer Hicran , Gumus Mahmut 
Published: February 2018

AbstractObjectiveResearch examining the relationship between metacognitions and cancer has only recently begun to emerge. This study attempted to compare the metacognitions of the patients with and without cancer. The effects of stage of cancer, type of cancer, and treatment modality (chemotherapy, radiotherapy, operation) on metacognitions were investigated. Patients with cancer were hypothesized to have higher levels of negative metacognitions.MethodsParticipants were patients with cancer (N = 279) and patients without cancer (control group, N = 212). The Metacognition Questionnaire‐30 was administered to all participants. Results were analyzed according to demographic and histopathological characteristics of the patients.ResultsThe results showed that patients with different cancer diagnoses scored higher than the controls on all subscales of the MCQ‐30. Those who received chemotherapy scored the highest on the MCQ‐30. The patients who were in early stages of cancer had higher levels of negative metacognitions. Patients who did not have operation but had chemotherapy had the highest levels of negative metacognitions. Patients who were in locally advanced stage, did not have operation but had received or was receiving chemotherapy had the highest levels of negative metacognitions.ConclusionsPatients who were in early stages of cancer appeared to be in greater need for psychological help and access to services. Findings indicated a need for psychological support for patients who undergo chemotherapy.
Serum vitamin D profile of Nigerian children with asthma: Association with asthma severity and control
Authors: Omole Kehinde O. , Kuti Bankole P. , Oyelami Oyeku A. , Adegbola Adebanjo J. , Omole John O. 
Published: February 2018

ObjectiveChildhood asthma is a chronic inflammatory airway disorder with increasing prevalence even in Africa. Vitamin D, with anti‐inflammatory and immune‐modulatory properties, may have effects on the severity and level of symptoms control in childhood asthma. We aimed to assess the serum vitamin D levels in children with asthma as related to disease severity and control in a tropical region.MethodsA hospital based comparative cross sectional study was conducted in western Nigeria. Serum vitamin D (25‐OH‐D) levels of all the children, assayed using high‐performance liquid chromatography (HPLC), were compared to the various disease severity and levels of asthma control as well as between the asthmatic and non‐asthmatic children.ResultsA total of 206 children (103 asthmatics and 103 non‐asthmatics) were recruited with a mean (SD) age of 6.6 (3.7) years. The majority (82.5%) of the children with asthma had mild intermittent form, 63.1% had well controlled symptoms while 33.0% and 3.9% had partly controlled and uncontrolled symptoms, respectively. None of the children were deficient in vitamin D. The mean (SD) serum vitamin D levels of the children with asthma (49.2 [7.2] ng/mL) was significantly lower than those without asthma (51.2 [6.9] ng/mL, P = 0.043). Varying degrees of asthma severity and levels of symptoms control were not affected by serum vitamin D levels.ConclusionChildren with asthma in Nigeria had marginally but significantly lower mean serum vitamin D levels when compared with their counterparts without asthma. However, serum vitamin D level does not seem to be associated with childhood asthma severity and control in these children with normal serum vitamin D levels.
A Novel Method for Assessment of the Velocity of Detonation for Primary Explosives
Authors: Jafari Mohammad , Keshavarz Mohammad Hossein , Zamani Ahmad , Zakinejad Sajjad , Alekaram Iman 
Published: February 2018

AbstractPrimary explosives are hazardous energetic materials with considerable sensitivities to external stimuli such as impact, friction, flame, heat, electric spark, and shock. A novel correlation has been introduced for prediction of detonation velocities of different hazardous primary explosives. The needed data for the new model are the loading density, the heat of detonation, the sum of the moles of gaseous products per gram of explosive and the average molecular weight of gaseous products. Decomposition products were specified based on the oxygen balance of primary explosives. Cross‐validation of the model and the statistical parameters were used for evaluating the goodness‐of‐fit, goodness‐of‐prediction, accuracy, and precision of the new model. The statistical parameters of the new model, as compared to the outputs of one of the best available thermochemical computer codes, confirm the higher reliability of the new correlation.
Time‐dependent effect of phytocannabinoid treatments in fat cells
Authors: Ramlugon S. , Levendal R.‐A. , Frost C.L. 
Published: February 2018

The objectives of this paper is to investigate, demonstrate, and compare the mechanism of action of phytocannabinoids as antidiabetic and anti‐obesity agents in preadipocytes and adipocytes, relative to rosiglitazone and metformin. Briefly, cannabis extract, Δ9‐tetrahydrocannabinol and cannabidiol (in very low dosages) were shown to promote glucose uptake higher or to equivalent levels, reduce fat accumulation, and reverse the insulin‐resistant state of 3T3‐L1 cells more effectively, relative to rosiglitazone and metformin. The phytocannabinoids had a more pronounced effect in preadipocytes undifferentiated model rather than the differentiated model. They induced a protective effect at the mitochondrial level by preventing overactivity of the succinate dehydrogenase pathway (p < .01), unlike rosiglitazone, through activation of the glycerol‐3‐phosphate dehydrogenase shuttling system. An increase in oxygen consumption and an increased expression of beta to alpha adrenoceptors (p < .05) in treated cells were noted. These findings contribute toward understanding the mechanism of action of phytocannabinoids in fat cells and highlight the antidiabetic and anti‐obesity properties of various phytocannabinoids that could potentially support the treatment of obesity‐related insulin resistance.
Comparative study of obstetric and neonatal outcomes of live births between poor‐ and good‐quality embryo transfers
Authors: Akamine Kozue , Mekaru Keiko , Gibo Keiya , Nagata Chinatsu , Oishi Sugiko , Miyagi Maho , Heshiki Chiaki , Kinjo Tadatugu , Masamoto Hitoshi , Aoki Yoichi 
Published: February 2018

AbstractPurposeTo evaluate the effect of embryo quality on pregnancy outcomes.MethodsThis retrospective analysis included 80 live singleton births, resulting from morphologically good‐quality embryo transfers, and 25 live singleton births that resulted from morphologically poor‐quality embryo transfers between January, 2008 and December, 2014. Cleavage embryos that were graded as ≥2, according to the Veeck classification system, and blastocysts that were graded as ≥3BB, according to the Gardner classification system, were defined as good quality. The obstetric and neonatal outcomes were compared between the poor‐ and good‐quality embryo transfer groups.ResultsThe mean maternal age between the groups was similar. The blastocyst transfer rate was higher in the good‐quality, than in the poor‐quality, embryo transfer group. Other characteristics, including parity, infertility duration, the intracytoplasmic sperm injection rate, frozen‐thawed embryo transfer rate, endometrial thickness, and hormone values before the embryo transfer, were similar between the groups. The obstetric and neonatal outcomes of live births between the two groups were not different in terms of preterm delivery, birthweight, small or large size for gestational age, malformation, umbilical artery cord pH of <7.20, hypertensive disorders of pregnancy, gestational diabetes mellitus, chorioamnionitis, placenta previa, and placental abruption.ConclusionThe obstetric and neonatal outcomes of live births between the poor‐ and good‐quality embryo transfers were equivalent.
Flume simulations of salmon bioturbation effects on critical shear stress and bedload transport in rivers
Authors: Buxton T.H. 
Published: February 2018

AbstractNest (redd) construction by female salmonids involves sequences of pit excavation and filling that winnow fines, loosen grains, and moves sediment downstream into a tailspill mound shaped like a dune. Prior research suggests that such bioturbation may destabilize streambeds by reducing friction between grains and converging flow that elevates shear stress on tailspills. Bed stability may alternatively be enhanced by form drag from redds that lowers basal shear stress, an effect that varies with the proportion of the bed that is occupied by redds (P). I used simulated redds and water‐worked (“unspawned”) beds in a laboratory flume to evaluate these competing influences on critical conditions and bedload transport in experiments with P = 0.11 (1 redd), 0.29 (2 redds), and 0.38 (3 redds). Results from competence (largest grain) and reference transport rate estimates of Shields stress indicate that particle entrainment inversely related to P. Bedload transport rates also increased as exponential functions of P and the boundary shear stress that exceeded critical conditions. Therefore, redd form drag did not overcome the destabilizing effects of redd construction. Instead, grain mobility and bedload transport increased with P because larger bed areas were composed of relatively loose grains and redd topography that experiences elevated shear stresses, as suggested in prior research. By winnowing fines and increasing bed surface mobility that exposes small particles in subsurface areas to flow, bioturbation by salmon can mitigate fine sedimentation of streambeds, which suggests an active role for salmon in restoring fish habitat in streams.
Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
Authors: Tang Jun-Nan , Cores Jhon , Huang Ke , Cui Xiao-Lin , Luo Lan , Zhang Jin-Ying , Li Tao-Sheng , Qian Li , Cheng Ke 
Published: February 2018

Abstract
Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using them to target disease.
Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment‐Independent 3D QSAR Models
Authors: Božić Aleksandra R. , Bjelogrlić Snežana K. , Novaković Irena T. , Filipović Nenad R. , Petrović Predrag M. , Marinković Aleksandar D. , Todorović Tamara R. , Cvijetić Ilija N. 
Published: February 2018

AbstractDue to the rise of microbial strains resistant to conventional therapies, there is an urgent need for finding the new antimicrobial chemotypes. Heterocyclic compounds such as thiocarbohydrazones (TCHs) are able to interact with many metalloenzymes essential for microbes, while sulfur atom increases lipophilicity which is generally positively correlated with potency. In this paper, we report antibacterial and antifungal activity of twenty‐two TCHs toward eight bacterial and three fungal strains. Furthermore, three alignment independent 3D QSAR models based on descriptors derived from molecular interaction fields (MIFs) are developed in order to rationalize structure‐activity relationships for activities of TCHs toward S. aureus, P. aeruginosa and C. albicans. Several structural fragments important for biological activity are recognized in each model, and structural modifications which could lead to increased potency are suggested. Designed structures will be synthesized accordingly and tested toward the same microbial strains in order to obtain more potent derivatives.
Experimental Speciation of Plutonium(IV) in Natural Seawater
Authors: Dumas Thomas , Guigue Mireille , Moisy Philippe , Colina‐Ruiz Roberto , Mustre de Leon Jose , Matara‐Aho Minja , Solari Pier Lorenzo , Monfort Marguerite , Moulin Christophe , Beccia Maria Rosa , Auwer Christophe Den 
Published: February 2018

AbstractSolubility, migration, and bioavailability of plutonium is lacunar because experimental evidences are missing. We report here on X‐ray Absorption Spectroscopy of plutonium in natural seawater. The observed valence state is +IV and its speciation corresponds to PuO2 type colloids. Furthermore, aging of the solution shows a gradient of ordering from hydroxide colloidal species to more crystalline PuO2 colloids.
Ascorbic Acid as a Highly Efficient Organocatalyst for ipso‐Hydroxylation of Arylboronic Acid
Authors: Das Sameeran Kumar , Bhattacharjee Prantika , Bora Utpal 
Published: February 2018

AbstractAn effective organocatalyst, ascorbic acid has been successfully applied for the ipso‐hydroxylation of arylboronic acid using 30% aqueous H2O2 as oxidant in water at ambient temperature. The methodology proceeds without using any metal catalyst or base and avoids harsh reaction conditions. The protocol is applicable to various electronically diverse arylboronic acid moieties with good to excellent yield.
Exploring the Effect of Introducing a π‐Bridge on The Efficiency of a Perylene‐Brazilein Based D‐D‐π‐A System: A Theoretical Perspective
Authors: Manzoor Taniya , Pandith Altaf Hussain 
Published: February 2018

AbstractWe report theoretical studies on some perylene based dyes for their electron transfer properties in solar cell applications. The study involves modeling of Donor‐π‐Donor‐π‐Acceptor (D‐π‐D‐π‐A) systems with perylene and brazilein as the two donors, cyanoacrylic acid group as acceptor, thiophene as the π‐bridge between the brazilein and acceptor and a varying π‐Bridge between the two donors . The effect of introducing a π‐bridge as well as varying the π‐bridges on the efficiency of a perylene‐brazilein based D‐D‐π‐A framework was evaluated in terms of various opto‐electronic and photovoltaic parameters affecting cell efficiency. All quantum computations were carried out using Density functional theory (DFT) using 6‐311G(d, p) / LanL2DZ (for I and Ti atoms) as the basis sets and B3LYP as the functional, both in the gas phase as well as solvent phase, with Gaussian 03 set of codes. We found that the sensitizers show good optical as well as photovoltaic response. The dye molecules with benzene (PB2), pyrimidine (PB7), pyrazine (PB8) and aniline (PB9) as π‐bridges exhibit better electron injection efficiencies and are hence, expected to be better sensitizers. The overall opto‐electronic and transport parameters of the TiO2 ‐ dye adsorbed systems after anchoring the dyes on the model TiO2 cluster was also studied which revealed that the dye molecules are expected to be good sensitizers.
Aqueous Chloroplatinic Acid: A Green, Chemoselective and Reusable Catalyst for the Deprotection of Acetals, Ketals, Dioxolanes and Oxathiolanes
Authors: Anil Seegehalli M , Vinayaka Ajjampura C , Rajeev Narasimhamurthy , Swaroop Toreshettahally R , Mallesha Ningegowda , Rangappa Kanchugarakoppal S , Sadashiva Maralinganadoddi P 
Published: February 2018

AbstractAqueous chloroplatinic acid (H2PtCl6) as an effective catalyst for the deprotection of acetals, ketals, 1,3‐dioxolanes and 1,3‐oxathiolanes to the corresponding carbonyl compounds in 56–99% yield has been reported. In addition, the catalyst has high‐selectivity in cleaving vicinol diol protection, yielding mono‐protected diols from di‐protected diols as a product. The present deprotection method is novel, chemoselective and offers broad functional group tolerance with short reaction time. Besides, the reaction protocol can be accomplished at ambient temperature and the catalyst is reusable.
Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy
Authors: Miao Zhao‐Hua , Lv Lan‐Xiang , Li Kai , Liu Pei‐Ying , Li Zhenglin , Yang Huanjie , Zhao Qingliang , Chang Manli , Zhen Liang , Xu Cheng‐Yan 
Published: February 2018

AbstractNear‐infrared light‐mediated theranostic agents with superior tissue penetration and minimal invasion have captivated researchers in cancer research in the past decade. Herein, a probe sonication‐assisted liquid exfoliation approach for scalable and continual synthesis of colloidal rhenium disulfide nanosheets, which is further explored as theranostic agents for cancer diagnosis and therapy, is reported. Due to high‐Z element of Re (Z = 75) and significant photoacoustic effect, the obtained PVP‐capped ReS2 nanosheets are evaluated as bimodality contrast agents for computed tomography and photoacoustic imaging. In addition, utilizing the strong near‐infrared absorption and ultrahigh photothermal conversion efficiency (79.2%), ReS2 nanosheets could also serve as therapeutic agents for photothermal ablation of tumors with a tumor elimination rate up to 100%. Importantly, ReS2 nanosheets show no obvious toxicity based on the cytotoxicity assay, serum biochemistry, and histological analysis. This work highlights the potentials of ReS2 nanosheets as a single‐component theranostic nanoplatform for bioimaging and antitumor therapy.
Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness
Authors: Xiang Shengnan , Sarem Melika , Shah Samveg , Shastri V. Prasad 
Published: February 2018

AbstractNanomedicines can be taken up by cells via nonspecific and dynamin‐dependent (energy‐dependent) clathrin and caveolae‐mediated endocytosis. While significant effort has focused on targeting pathway‐specific transporters, the role of nanobiophysics in the cell lipid bilayer nanoparticle uptake pathway remains largely unexplored. In this study, it is demonstrated that stiffness of lipid bilayer is a key determinant of uptake of liposomes by mammalian cells. Dynamin‐mediated endocytosis (DME) of liposomes is found to correlate with its phase behavior, with transition toward solid phase promoting DME, and transition toward fluidic phase resulting in dynamin‐independent endocytosis. Since liposomes can transfer lipids to cell membrane, it is sought to engineer the biophysical properties of the membrane of breast epithelial tumor cells (MD‐MBA‐231) by treatment with phosphatidylcholine liposomes, and elucidate its effect on the uptake of polymeric nanoparticles. Analysis of the giant plasma membrane vesicles derived from treated cells using flicker spectroscopy reveals that liposome treatment alters membrane stiffness and DME of nanoparticles. Since liposomes have a history of use in drug delivery, localized priming of tumors with liposomes may present a hitherto unexploited means of targeting tumors based on biophysical interactions.
Security policy monitoring of BPMN‐based service compositions
Authors: Asim Muhammad , Yautsiukhin Artsiom , Brucker Achim D. , Baker Thar , Shi Qi , Lempereur Brett 
Published: February 2018

AbstractService composition is a key concept of Service‐Oriented Architecture that allows for combining loosely coupled services that are offered and operated by different service providers. Such environments are expected to dynamically respond to changes that may occur at runtime, including changes in the environment and individual services themselves. Therefore, it is crucial to monitor these loosely coupled services throughout their lifetime. In this paper, we present a novel framework for monitoring services at runtime and ensuring that services behave as they have promised. In particular, we focus on monitoring non‐functional properties that are specified within an agreed security contract. The novelty of our work is based on the way in which monitoring information can be combined from multiple dynamic services to automate the monitoring of business processes and proactively report compliance violations. The framework enables monitoring of both atomic and composite services and provides a user friendly interface for specifying the monitoring policy. We provide an information service case study using a real composite service to demonstrate how we achieve compliance monitoring. The transformation of security policy into monitoring rules, which is done automatically, makes our framework more flexible and accurate than existing techniques.
Understanding the Selection Mechanism of the Polymer Wrapping Technique toward Semiconducting Carbon Nanotubes
Authors: Salazar‐Rios Jorge Mario , Talsma Wytse , Derenskyi Vladimir , Gomulya Widianta , Keller Tina , Fritsch Martin , Kowalski Sebastian , Preis Eduard , Wang Ming , Allard Sybille , Bazan Guillermo Carlos , Scherf Ullrich , dos Santos Maria Cristina , Loi Maria Antonietta 
Published: February 2018

AbstractNoncovalent functionalization of single‐walled carbon nanotubes (SWNTs) using π‐conjugated polymers has become one of the most effective techniques to select semiconducting SWNTs (s‐SWNTs). Several conjugated polymers are used, but their ability to sort metallic and semiconducting species, as well as the dispersions yields, varies as a function of their chemical structure. Here, three polymers are compared, namely, poly[2,6‐(4,4‐bis‐(2‐dodecyl)‐4H‐cyclopenta[2,1‐b;3,4b′]dithiophene)‐alt‐4,7(2,1,3‐benzothiadiazole)] (P12CPDTBT), poly(9,9‐di‐n‐dodecylfluorenyl‐2,7‐diyl) (PF12), and poly(3‐dodecylthiophene‐2,5‐diyl) (P3DDT) in their ability to select two types of carbon nanotubes comprising small (≈1 nm) and large (≈1.5 nm) diameters. P12CPDTBT is a better dispersant than PF12 for small diameter nanotubes, while both polymers are good dispersants of large diameter nanotubes. However, these dispersions contain metallic species. P3DDT, instead presents the best overall performance regarding the selectivity toward semiconducting species, with a dispersion yield for s‐SWNTs of 15% for small and 21% for large diameter nanotubes. These results are rationalized in terms of electronic and chemical structure showing that: (i) the binding energy is stronger when more alkyl lateral chains adsorb on the nanotube surface; (ii) the binding energy is stronger when the polymer backbone is more flexible; (iii) the purity of the dispersions seems to depend on a strong polymer–nanotube interaction.
Effects of Temperature and Spatial Scale on Rio Grande Cutthroat Trout Growth and Abundance
Authors: Huntsman Brock M. , Martin Roy W. , Patten Kirk A. 
Published: February 2018

AbstractPopulation persistence across broad spatial scales (e.g., watersheds) can depend on asynchronous dynamics among populations at finer scales (e.g., streams or habitats). We applied a von Bertalanffy growth model and closedN‐mixture abundance model in a hierarchical Bayesian framework to examine effects of fine‐scale variability in temperature and density dependence on growth and abundance as well as within‐ versus among‐stream variability in growth and abundance of Rio Grande Cutthroat TroutOncorhynchus clarkii virginalis(RGCT) in northern New Mexico streams. An accumulation of degree‐days positively influenced instantaneous growth rates and, to a lesser extent, negatively affected asymptotic body length. A nonlinear response of abundance to temperature was also observed, suggesting thatRGCTproductivity along the temperature continuum was affected by physiological limitations (e.g., optimal growth temperatures). Variability inRGCTabundance and the asymptotic size parameter could not be distinguished with certainty between spatial scales but was greatest at the stream level for the rate at which asymptotic size was reached. In total, our results suggested thatRGCTproductivity in our study streams was influenced by mechanisms operating at multiple spatial scales. Management actions should consider processes not only at the stream scale but within streams for improving the likelihood of future population persistence.