bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCREENING FOR ANTI-QUORUM SENSING AND ANTI-BIOFILM ACTIVITY IN Viscum album L. EXTRACTS AND ITS BIOCHEMICAL COMPOSITION
Authors: ERDÖNMEZ Demet , KENAR Nihal , ERKAN TÜRKMEN Kübra 
Published: October 2018

Many opportunistic pathogenic bacteria use the Quorum Sensing (QS) system to coordinate their virulence expressions. Thus, QS can likely be a new approach to control bacterial infections. The aim of this study was to evaluate the antimicrobial, anti-biofilm, and anti-quorum sensing activities of ethanol, chloroform, and dichloromethane: methanol extracts of leaf, stem, and fruits of the European mistletoe Viscum album L. on 2 Gram-positive and 7 Gram-negative pathogenic bacteria. The extracts at concentrations ranging from 50 to 250mg/ml were tested depending on the extracts of the plant parts and the test bacteria. The extract with 50mg/ml concentration, in which no antimicrobial activity was observed, was used for anti-quorum sensing and antibiofilm studies. The dichloromethane: methanol extracts were found to show the highest biological activities. QS activities of the plant extracts were also determined using the recently established Chromobacterium violaceum CV026 reporter strain and the signaling molecule N-(ß-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL) agar well diffusion assay. Biofilm was quantified using the microtiter plate test and the crystal violet assay. Anti-microbial, anti-biofilm, and anti-quorum sensing activity of leaf and stem extracts showed higher efficiency than fruit extracts. It was concluded that the extracts of V. album had the potential to treat microbial infections by biofilm inhibition or inhibition of QS.
STUDI LITERATUR : PERAN STRATIFIKASI SOSIAL MASYARAKAT DALAM PEMBENTUKAN POLA PERMUKIMAN
Authors: Rahman Boby , Selviyanti Ega 
Published: October 2018

ABSTRACTSocio and cultural system which believed as the result of relationship, communication, individual socialization in society has an effect on the form of the society’s environmental order. The effect of relationship, communication and socialization which created a social system of society that makes the society divided into layers or positions based on believes values, norms and customs in society. This study uses literature study in reviewing the effect of social stratification with taking case study in Solo, Bali and Madura. The result of this study can be concluded that social stratification has a role in the formation of society settlements. That social stratification then forms a society environmental order in both spatial and physical architecture of buildings. Keywords: social stratification, settlements formation, settlement pattern ABSTRAKSistem sosial dan budaya yang dipercayai sebagai hasil hubungan,komunikasi, sosialisasi individu dalam masyarakat mempunyai pengaruh atas bentuk tatanan lingkungan masyarakat. Akibat dari hubungan, komunikasi dan sosialisasi dalam masyarakat sehingga terciptalah sistem sosial masyarakat yang menjadikan masyarakat terbagi dalam lapisan-lapisan atau kedudukan berdasarkan kepercayaan, nilai, norma dan adat istiadat dalam masyarakat. Penelitian ini menggunakan pendekatan studi literature dalam mengkaji pengaruh stratifikasi sosial, dengan mengambil studi kasus di Solo, Bali dan Madura. Hasil dari kajian ini dapat disimpulkan bahwa stratifikasi sosial mempunyai peran pembentukan permukiman masyarakat. Stratifikasi sosial tersebut kemudian membentuk tatanan lingkungan pola lapisan permukiman masyarakat baik yang bersifat spatial maupun fisik arsitektur bangunan..Kata Kunci: Stratifikasi Sosial, Pembentukan Permukiman, Pola Permukiman
OS PRINCIPAIS FATORES DE RISCO DA PNEUMONIA ASSOCIADA À VENTILAÇÃO MECÂNICA EM UTI ADULTA.
Authors: Barbieri Costa Janice , Alessandro Lima Costa Lima Alessandro , Torres Fernanda , de Fátima Galdino da Silva Antônia , Tomaz Terra Júnior André 
Published: October 2018

A pneumonia é uma inflamação do parênquima pulmonar causada por diversos agentes etiológicos, as pneumonias hospitalares são causadas principalmente por Enterobacter, Escherichia coli, Klebsiella, Proteus, Serratia marcescens, Pseudomonas aeruginosa e Staphylococcus aureus. A pneumonia associada à ventilação mecânica (PAVM) é considerada a infecção nosocomial mais frequente em unidades de terapia intensiva (UTI) e é definida como uma inflamação do parênquima pulmonar, que aparece após 48 a 72 horas da intubação endotraqueal e do inicio da ventilação mecânica. O objetivo desse trabalho foi demonstrar os principais fatores de risco para a aquisição da PAVM. A pesquisa de revisão literária se deu através de base de dados, como PubMed e Bireme, LILACS, SciELO, o período de publicação compreenderam os anos de 1998 á 2013. A PAVM possui alguns fatores de risco, que são classificados em modificáveis ou não modificáveis. Alguns exemplos desses fatores de risco não modificáveis são: idade, gravidade da doença de base, Doença Pulmonar Obstrutiva Crônica (DPOC). E os fatores modificáveis alguns exemplos são: educação continuada dos profissionais sobre os fatores de risco, o estabelecimento de protocolos que evitem o uso indiscriminado de antibióticos. Conclui-se através dessa revisão literária que a maioria dos pacientes internados em UTI está em ventilação mecânica (VM) e que nos pacientes intubados, a incidência de pneumonia é de 7 a 21 vezes mais elevado em relação àqueles que não necessitam de ventiladores e por isso são necessárias medidas preventivas.
Desain prototipe aplikasi sistem monitoring browser ponsel anak untuk menerapkan internet sehat dengan kontrol orang tua
Authors: Hidayat Taufik , Mansur Mansur , Rahmah Rahmah 
Published: October 2018

Abstrak- Penggunaan internet dikalangan anak-anak saat ini sudah menjadi trend, bahkan banyak orang tua sudah memberikan ponsel android kepada anak-anak dalam melakukan komunikasi sehari-hari. Hal tersebut sangat berdampak kepada anak dalam pemanfaatan teknologi internet yang kurang sehat seperti mendapatkan data dan informasi melalui browsing internet tanpa pemantauan orang tua sehingga anak dengan mudah mendapatkan kata-kata atau informasi yang tidak layak dikonsumsi oleh anak tersebut. Penelitian ini bertujuan untuk mendesain aplikasi sistem monitoring browser ponsel anak untuk menerapkan internet sehat dengan kontrol orang tua menggunakan metode prototipe. Hasil penelitian tersebut berupa rancangan aplikasi monitoring broser anak yang dapat digunakan untuk memantau aktivitas browsing internet pada ponsel anak secara online pada platform android dengan otomatis mengirim pesan notifikasi kepada orang tua dan orang tua dapat memberikan respon atau balasan secara langsung ketika anak sedang mencoba melakukan aktivitas browsing internet yang tidak sehat.
Kata kunci: Kontrol orang tua, penelusuran aman, sistem monitoring, aktivitas penelusuran harian
Abstract- The use of the internet among children currently have become a trend, even many parents already gives android phones to children in doing everyday communication. It is so impacting to the child in the utilization of internet technologies that are less healthy as get data and information through browsing the internet without monitoring parents so children easily get words or information that is not feasible is consumed by the child. This research aims to design a monitoring system of the mobile browser app to implement a healthy internet parental control method using prototype. The results of such research in the form of a draft application monitoring these children which can be used to monitor the activities of internet browsing on mobile child online on the android platform with automatic notification to send a message to parents and parents can give a response or reply directly when the child was trying to do internet browsing activity that is not healthy.
Keywords: Parental Control, Safe Browsing, Monitoring System, Daily Browser Activity
Analisis dan Perancangan Situs Web Pemasaran Berbasis Intranet pada PT Radio Sonora
Authors: Wibowo Teguh Hari , Utami Viany 
Published: October 2018

PT Radio Sonora merupakan anak perusahaan dari Kompas Gramedia Group yang bergerak dalam bidang saluran radio yang sudah cukup terkenal dan memiliki berbagai unit cabang di beberapa daerah di Indonesia. Penelitian ini bertujuan untuk menganalisis dan merancang situs web untuk bagian pemasaran pada PT Radio Sonora. Perancangan situs web ini menggunakan perancangan analisis terstruktur dengan metode waterfall model dan menggunakan flowchart diagram dan entity relationship diagram untuk menggambarkan sistem dari situs web yang akan dibuat. Situs web yang dibuat ini dirancang untuk meningkatkan kemampuan bagian pemasaran dalam mengelola informasinya.
Kata kunci—analisis, perancangan, situs web, intranet, pemasaran
Pemodelan Employee Self Service Sistem Sebagai Penunjang Human Resources Department
Authors: Oktavia Tanty 
Published: October 2018

The background of this research is based on the operational needs in human resources department to organize all the data and business processes that occur in this division. The role of the Human Resources division significantly to manage labor resources that contribute to the implementation of the organization’s operations. The objectives in this research is to build a model of information system that can support the operation in employee management system, which consists of employees’ personal data, attendance report, and document about employees competence. The method of this research refers to model lifecycle database [1]. The results achieved in this study was the establishment of a model of information systems and database design that can support the operations of the Human Resources Department that can be operated and controlled directly by the relevant employees, so that the operational process can be performed effectively and efficiently.
Keywords: information system, human resources department, database lifecycle.
Sim Card Alarm for Android Smartphone
Authors: Ginanjar Rikip , Utomo Ridho 
Published: October 2018

Since the first Android smartphones were released, many applications have been developed until today. One of them is security application. Security applications consist of several types of applications such as Antivirus, SIM Card Change Alarm, and Applocker. SIM Card Changed Alarm is a security application that has capability to monitor SIM Card change in Android smartphones. Although there are many SIM Card Change Alarm applications which are available in Google Playstore, there are many people who are not satisfied with this applications. It happens due to them only sends the SMS alert to the owner without locking the phone to prevent other people using it. The outcome of this research will have the same feature as SIM Card Change Alarm but with additional features such as locking the smartphone if the SIM Card has been changed, locking and unlocking remotely using SMS, triggering loud alarm, and calling-back to owner when the smartphone has been lost or stolen. The outcome expected for the Prifone Application is a userfriendly application which could be used by many people around the world and also is able to secure Android smartphones.
Index Terms – android, sim card alarm, security application
Representaciones sociales de la democracia en estudiantes colombianos: un análisis multidimensional y cartográfico
Authors: Ruiz Pérez José Ignacio Ruiz Pérez , Pineda Silva Angélica , Ever José López Ever José López 
Published: October 2018

Este trabajo se propone conocer las representaciones sociales de la democracia presentes en estudiantes colombianos de carreras de educación superior, y la relación que estas guardan con las variables de victimización, pertenencia geográfica y sociodemográfica. Así mismo, se busca conocer la forma cómo se distribuye la valoración de la democracia a nivel geográfico puesto que las variables socioeconómicas y del conflicto armado inciden de forma diferencial en las regiones del país. Para ello, se cuenta con una muestra no aleatoria (n=3300) de carreras universitarias y técnicas-tecnológicas de 31 de los 32 departamentos del país, que respondieron un cuestionario cerrado compuesto, entre otras secciones, por una Escala de Representaciones Sociales de la Democracia y una Escala de Victimización. Entre los resultados se encontraron cuatro dimensiones de la democracia: valores, aspectos electorales, desconfianza y corrupción. El posicionamiento de los sujetos en estas dimensiones estuvo relacionado con la clase entre un indicador de valoración de la democracia con la victimización criminal. social y las experiencias de victimización de forma compleja. En esta vía, una proyección cartográfica muestra que no hay una relación lineal entre un indicador de valoración de la democracia con la victimización criminal.
Sentido del humor y empatía en maestras de primaria: reflexiones sobre su impacto en la enseñanza
Authors: Putrino Natalia Ines , Sasso Romina , Mustaca Alba 
Published: October 2018

El objetivo de este trabajo es estudiar la relación entre los estilos de humor adaptativos y desadaptativos con la empatía cognitiva y afectiva en maestras. Se trabajó con una muestra de 84 maestras argentinas, quienes respondieron a dos escalas: Test de empatía cognitiva y afectiva (TECA, López- Pérez, Fernández- Pinto & Abad, 2008), y a la versión adaptada al español y en la población argentina por Cayssials y Perez (2005) de la Escala de Estilos de Humor (Martin, 2003). Los resultados indican una relación significativa entre el tipo de humor afiliativo y las cuatro subescalas de empatía, como también entre el humor descalificación personal y el estrés empático. Por otro lado, la dimensión adopción de perspectiva predice negativamente al humor agresivo y el estrés empático predice positivamente el humor descalificación personal. Estos resultados se discutirán en función de estudios previos y de la posible importancia que tienen para la docencia.
"kapazitär" wie "autoritär" – Neue Adjektive auf "-itär"
Authors: Buchmann Franziska 
Published: October 2018

Besides some well-established forms like autoritär 'authoritarian'; humanitär 'humanitarian'; new coinages ending with -itär can be found in German. These adjectives are closely related to nouns ending with -ität. From an etymological point of view; these formations are morphologically transparent. Not only are the adjectives new; but -itär emerges as a new suffix.

Dieser Beitrag ist ursprünglich im Peter-Lang-Verlag erschienen (https://www.ingentaconnect.com/contentone/plg/jwf/2018/00000002/00000002/art00001)
Treatment at low‐volume hospitals is associated with reduced short‐term and long‐term outcomes for patients with retroperitoneal sarcoma
Authors: Keung Emily Z. , Chiang Yi‐Ju , Cormier Janice N. , Torres Keila E. , Hunt Kelly K. , Feig Barry W. , Roland Christina L. 
Published: October 2018

BackgroundRetroperitoneal sarcomas (RPS) are rare tumors for which complete surgical resection remains the mainstay of treatment. The objective of the current study was to determine the impact of hospital case volume on outcomes in patients with RPS.MethodsA total of 6950 patients with primary RPS who underwent surgical resection were identified from the National Cancer Data Base (1998‐2011). Treating hospitals were classified by annual case volume; low‐volume hospitals (LVHs) and high‐volume hospitals (HVHs) were defined as those with ≤10 cases per year and >10 cases per year, respectively. Overall survival (OS) was compared using Kaplan‐Meier curves. Cox proportional hazard models were created to compare risks.ResultsOf the 1131 reporting hospitals, the majority (1127 hospitals; 99.6%) were LVHs treating the majority of patients (6270 patients; 90.2%). Patients treated at LVHs were more likely to have lower grade and smaller tumors, receive radiotherapy, and undergo incomplete macroscopic (R2) resection. Patients treated at HVHs had lower 30‐day readmission rates (1.8% vs 3.4%; P<.001), 30‐day (1.9% vs 3.1%; P=.004) and 90‐day (3.2% vs 5.7%; P=.007) mortality, longer median OS (76.2 months vs 64.2 months; P<.001), and higher 5‐year OS rates (58% vs 52%; P<.001). After controlling for age, sex, insurance status, tumor size, tumor grade, surgical resection margin status, and radiotherapy administration, treatment at an HVH was found to be independently associated with a reduced risk of death (hazard ratio, 0.77; 95% confidence interval, 0.65‐0.91 [P=.003]).ConclusionsPrimary RPS are rare tumors, and to our knowledge few surgeons and institutions have significant experience and expertise in their multidisciplinary management and surgical resection. Although additional studies are needed, patient outcomes may be impacted by the case volume and expertise of the treating facility.
Long noncoding RNA C21orf121/bone morphogenetic protein 2/microRNA‐140‐5p gene network promotes directed differentiation of stem cells from human exfoliated deciduous teeth to neuronal cells
Authors: Liu Jun , Zhang Zeng‐Yu , Yu Hong , Yang Ai‐Ping , Hu Ping‐Fang , Liu Zhuo , Wang Min 
Published: October 2018

AbstractPrevious studies have revealed that long noncoding RNA (lncRNA) and microRNA play a crucial role in autism, which is a childhood neurodevelopmental disorder with complicated genetic origins. Hence, the study concerns whether lncRNA C21orf121/bone morphogenetic proteins 2 (BMP2)/miR‐140‐5p gene network affects directed differentiation of stem cells from human exfoliated deciduous teeth (SHED) to neuronal cells in rats with autism. Autism models were successfully established. The neuron cells that differentiated from SHED cell were identified. The expression of lncRNA C21orf121, miR‐140‐5p, BMP2, Nestin, βIII‐tubulin, and microtubule‐associated protein 2 (MAP2) and the expression of neuron‐specific enolase (NSE) were examined. Besides, the gap junction (GJ) function of SHED, the intracellular free Ca
2+ concentration, and the social behavior and repetitive stereotyped movements of rats in autism were detected. The target relationship between lncRNA C21orf121 and miR‐140‐5p and that between miR‐140‐5p and BMP2 were also verified. Firstly, we successfully isolated SHED and identified the differentiated neurons of SHED. Besides, the expression of BMP2, MAP2, Nestin, βIII‐tubulin, NSE positive rate, GJ function, and intracellular free Ca
2+ concentration were increased with the upregulation of C21orf121 and downregulation of miR‐140‐5p, and accumulated time of repetitive stereotyped movements decreased and the frequency of social behavior increased. The results indicate that lncRNA C21orf121 as a competing endogenous RNA competes with BMP2 binding to miR‐140‐5p, thereby promoting SHED to differentiate into neuronal cells via upregulating BMP2 expression.
Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells
Authors: Manuelidis Laura 
Published: October 2018

AbstractSmall circular DNAs of 1.8 and 2.4 kb were initially discovered in highly infectious Creutzfeldt‐Jakob Disease (CJD) and scrapie particles from mammalian brain and cultured cells. Surprisingly, these protected cytoplasmic "SPHINX" DNAs contained replication (REP) initiation sequences resembling those of Acinetobacter phage viruses. An antibody was generated against a REP peptide encoded by the SPHINX 1.8 open reading frame (ORF) that was not present in mammals. It bound to a 41kd “spx1” protein on Western blots. Cytologically, spx1 concentrated in spinal cord synapses and pancreatic islet, but not exocrine cells. We hypothesized that circular SPHINX DNAs are ancient symbiotic elements that can participate in functional differentiation and neurodegeneration. Cell and tissue‐specific patterns of spx1 expression shown below implicate somatic cell‐to‐cell communication and differentiation functions that would favor conservation of SPHINX 1.8 in evolution. Remarkably, primary human oocytes and spermatogonia, but not mature sperm, displayed intense cytoplasmic spx1 signals that underscore the maternal inheritance of SPHINX 1.8. These findings should encourage investigations of unexplored networks of incorporated environmental infectious agents that can be key actors in progressive neurodegeneration, immunity, and cancer.
Preoperative albumin‐to‐globulin ratio predicts survival in patients with non‐small‐cell lung cancer after surgery
Authors: Zhang Hua , Zhang Bin , Zhu Kaikai , Wu Chao , Gao Liuwei , Sun Xiaoyan , Liu Chang , Wang Changli 
Published: October 2018

AbstractThe prognostic value of the preoperative albumin‐to‐globulin ratio (AGR) has not been investigated in non‐small‐cell lung cancer (NSCLC). Therefore, we aimed to assess the clinical applicability of the preoperative AGR to predict the prognosis in patients with NSCLC. We retrospectively enrolled 545 patients with stage I/II/III NSCLC who underwent surgery at our institution. The cutoff value for preoperative AGR was calculated by using a receiver operating characteristic curve analysis. A low AGR was associated with several clinicopathological variables related to tumor progression. In the multivariate analyses, the preoperative AGR was identified as an independent prognostic factor for disease‐free survival (DFS; P = 0.003) and overall survival (OS; P = 0.005). For patients with stage II and III with a preoperative AGR ≤ 1.43, the surgery plus chemotherapy group had a significantly longer DFS and OS than the surgery alone group (P = 0.002 and P = 0.001, respectively); however, a significant difference in DFS and OS between these two groups was not observed in patients with stage II and III with an AGR > 1.43 (P = 0.808 and P = 0.842, respectively). The preoperative AGR is an independent, significant predictor of DFS and OS in patients with NSCLC. Our results also demonstrate that the preoperative AGR might be a predictive marker of the therapeutic effect of postoperative chemotherapy in patients with stage II and III NSCLC.
Exploring and comparing of the gene expression and methylation differences between lung adenocarcinoma and squamous cell carcinoma
Authors: Yang Yang , Wang Meng , Liu Bao 
Published: October 2018

AbstractLung cancer is one of the most frequently diagnosed malignant tumors and the main reason for cancer‐related death around the world, whereas nonsmall cell lung cancer that consists two subtypes: lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) is responsible for an estimated 85% of all lung cancers. The current study aimed to explore gene expression and methylation differences between LUAD and LUSC. EdgeR was used to identify differentially regulated genes between normal and cancer in the LUAD and LUSC extracted from The Cancer Genome Atlas (TCGA), respectively, whereas SAM was used to find genes with differential methylation between normal and cancer in the LUAD and LUSC, respectively. Finally, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed to analyze the function which these genes enriched in. A total of 391 genes with opposite methylation patterns in LUAD and LUSC and four functional pathways were obtained (false discovery rate (FDR) < 0.1). These pathways mainly included fat digestion and absorption, phenylalanine metabolism, bile secretion, and so on, which were related to the airframe nutrition metabolic pathway. Moreover, two genes CTSE (cathepsin E) and solute carrier family 5 member 7 (SLC5A7) were also found, among which CTSE was overexpressed and hypomethylated in LUAD corresponding to normal lung tissues, whereas SLC5A7 showed the opposite in LUAD. In conclusion, this study investigated the differences between the gene expression and methylation patterns in LUAD and LUSC, and explored their different biological characteristics. Further understanding of these differences may promote the discovery and development of new, accurate strategies for the prevention, diagnosis, and treatment of lung cancer.