bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzyltriethylammonium Chloride Electrolyte for High‐Performance Al‐Ion Batteries
Authors: Xu Cheng , Li Jialin , Chen Haixia , Zhang Jianxin 
Published: September 2019

AbstractAluminum ion batteries have attached more attention because of inherent advantages such as abundant Al source, low flammability, three‐electron‐redox property and high theoretical capacity. However, many problems exist in the electrolyte system of aluminum ion battery, such as high price, low capacity. We prepare a novel AlCl3/Benzyltriethylammonium chloride electrolyte for aluminum ion battery. The battery displays a good performance at high current densities: 102 mA h g−1 at 5 A g−1 with a coulombic efficiency of ∼98% and 91 mA h g−1 at 10 A g−1 after 1500 cycles. It only takes 13 seconds to be fully charged/discharged at the current density of 25 A g−1. The mechanism of intercalation/de‐intercalation of chloroaluminate anions is confirmed by characterization and we believe AlCl3/Benzyltriethylammonium chloride will be a promising electrolyte for aluminum ion batteries.
Field and numerical investigations of gateroad system failure under an irregular residual coal pillar in close‐distance coal seams
Authors: Shang Hefu , Ning Jianguo , Hu Shanchao , Yang Shang , Qiu Pengqi 
Published: September 2019

AbstractThe Gaojialiang Coal Mine in Inner Mongolia in China was used as an example to investigate the process of chain pillar and gateroad failure in the lower coal seam under the effect of an irregular residual coal pillar in the upper close‐distance coal seam. The results indicated that after the longwall face in the lower coal seam retreated through the area under the large irregular residual coal pillar in the upper coal seam, the bearing area of the residual coal pillar decreased and the roof pressure continuously concentrated in the elastic core area of the residual coal pillar. Isolated triangular slab rock was formed above the triangular residual coal pillar, and the weight of the overlying strata was transferred downward through the triangular slab rock. When the chain pillar under the residual coal pillar was destroyed due to loading that exceeded its carrying capacity, the upper triangular slab rock rotated and sank, which resulted in the intensification of the concentrated stress in the solid rib of the gateroad in the lower coal seam. Based on the analysis, it is suggested that in the design of a longwall system, a gateroad under an isolated residual coal pillar in the upper coal seam should be avoided when mining in close‐distance coal seams.
Trigonometric transforms and precoding strategies for OFDM‐based uplink hybrid multi‐carrier nonorthogonal multiple access
Authors: Trivedi Vinay Kumar , Ramadan Khaled , Kumar Preetam , Dessouky Moawad Ibrahim , Abd El‐Samie Fathi E. 
Published: September 2019

AbstractAn uplink hybrid nonorthogonal multiple access (h‐NOMA) scheme utilizing power domain multiplexing is adopted in this paper for orthogonal frequency–division multiplexing (OFDM)–based systems. The OFDM‐based NOMA systems can achieve high spectral efficiency with resilience to wireless multipath fading. The h‐NOMA maintains a low interference level per resource block or low complexity of multiuser detection (MUD) implementation at the receiver and also achieves consistent fairness performance by restricting the maximum number of users per resource block. An improved user clustering algorithm for OFDM‐based h‐NOMA system under the assumption of user's distinct data rate requirement is presented here. The proposed algorithm takes into consideration both the channel gain of all activated users and the different data rate requirements of weak channel gain users. High peak‐to‐average power ratio (PAPR) and performance degradation due to strict frequency synchronization requirements are the main drawbacks of such an OFDM‐based uplink h‐NOMA system. High PAPR of multicarrier NOMA is addressed here with precoding techniques. An enhanced minimum mean square error (MMSE) receiver performing joint equalization and carrier frequency offset (CFO) compensation using low‐complexity banded‐matrix implementation is proposed to cancel interference in the frequency domain. The MUD is implemented with low‐complexity successive interference cancellation (SIC) using bandedmatrix approximation of the interference matrix in the presence of CFO. Moreover, the possibility of utilizing efficient trigonometric transforms to implement OFDM‐based NOMA is studied with CFO and estimation errors. For OFDM‐based h‐NOMA system, an efficient combination of different trigonometric transform configurations to constitute the multicarrier basis for OFDM with a suitable precoding strategy for PAPR reduction is studied.
LightCert: On designing a lighter certificate for resource‐limited Internet‐of‐Things devices
Authors: Kwon Hyuksang , Ahn Jeongseob , Ko JeongGil 
Published: September 2019

AbstractInternet‐of‐Things (IoT) devices are typically resource constrained in terms of computing capabilities and battery power. Despite the efforts from the Internet Engineering Task Force (IETF) to established standards for IoT such as IPv6 over low‐power wireless personal area networks (6LoWPAN), routing protocol for low‐power lossy networks (RPL), and constrained application protocol (CoAP), certificate‐based Internet security protocols have not been fully addressed yet.We see the main cause of this being the size of the X.509‐based Internet certificates. Typically being 1 to 2 kB, the large size of these certificates can cause IEEE 802.15.4‐based IoT nodes to fragment the certificate into many smaller packet‐size chunks, which causes many packet transmissions to occur in the network. This work presents LightCert, a lightweight scheme to compress the size of the security certificates using the similarity of contents in X.509 certificates. Specifically, LightCert identifies common fields in a certificate and suppresses the transmission of these contents within the IoT subnet scope. This allows LightCert nodes to minimize the packet transmission overhead for supporting certificate‐based security mechanisms such as datagram transport layer security (DTLS), by as much as ∼37%. The added overhead of exchanging certificates when using LightCert is kept low to as much as ∼5 mJ of energy and ∼0.48 seconds of latency.
Clonal evolution of acute myeloid leukemia from diagnosis to relapse
Authors: Vosberg Sebastian , Greif Philipp A. 
Published: September 2019

AbstractBased on the individual genetic profile, acute myeloid leukemia (AML) patients are classified into clinically meaningful molecular subtypes. However, the mutational profile within these groups is highly heterogeneous and multiple AML subclones may exist in a single patient in parallel. Distinct alterations of single cells may be key factors in providing the fitness to survive in this highly competitive environment. Although the majority of AML patients initially respond to induction chemotherapy and achieve a complete remission, most patients will eventually relapse. These points toward an evolutionary process transforming treatment‐sensitive cells into treatment‐resistant cells. As described by Charles Darwin, evolution by natural selection is the selection of individuals that are optimally adapted to their environment, based on the random acquisition of heritable changes. By changing their mutational profile, AML cell populations are able to adapt to the new environment defined by chemotherapy treatment, ultimately leading to cell survival and regrowth. In this review, we will summarize the current knowledge about clonal evolution in AML, describe different models of clonal evolution, and provide the methodological background that allows the detection of clonal evolution in individual AML patients. During the last years, numerous studies have focused on delineating the molecular patterns that are associated with AML relapse, each focusing on a particular genetic subgroup of AML. Finally, we will review the results of these studies in the light of Darwinian evolution and discuss open questions regarding the molecular background of relapse development.
Comprehensive analysis of lncRNA‐TF crosstalks and identification of prognostic regulatory feedback loops of glioblastoma using lncRNA/TF‐mediated ceRNA network
Authors: Ji Yang , Gu Yaqin , Hong Shuai , Yu Bo , Zhang Jian‐Hua , Liu Jin‐Na 
Published: September 2019

AbstractGlioblastoma (GBM) has become the most aggressive primary brain tumor in the world. Patients with GBM usually have a poor prognosis. The median survival times of GBM patients retain less than 2 years. Thus, it is urgent to investigate the molecular mechanism of GBM. Recently, studies have demonstrated that transcription factors (TFs) participate in cancer pathology by regulating long noncoding RNAs (lncRNAs). However, the functional and regulatory roles of TF‐lncRNA crosstalks are still unclear. In this study, we constructed a global lncRNA‐TF network (GLTN) based on competing endogenous RNA. As a result, some topological features of GLTN were identified. A known GBM lncRNA MCM3AP‐AS1 showed multiple central topological features in GLTN. Furthermore, we identified hub genes and extracted the hub‐hub pairs from GLTN to form a hub associated lncRNA‐TF network (HALTN). Results showed that a risk model combined with multiple hubs had a significant effect on prognosis. Additionally, we performed module searching and two functional modules from HALTN were identified, which were confirmed as risk factors of GBM. More importantly, we also identified some core lncRNA‐TF crosstalks that might form feedback loops to control the biological processes in GBM. Our results demonstrated that the synergistic, competitive lncRNA‐TF crosstalks played an important role in pathological processes of GBM, and had strong effect on prognosis. All these results can help us to uncover the molecular mechanism and provide a new therapeutic target for GBM.
New sights on the associations between the XRCC1 gene polymorphisms and hepatocellular carcinoma susceptibility
Authors: Cai Wenjuan , Liu Xinhua , Li Yan , Bi Bowen , Liu Lei , Wang Zhenglu 
Published: September 2019

AbstractStudies investigating the relationships between the polymorphisms in the X‐ray repair cross complementing 1 (XRCC1) gene and the susceptibility of hepatocellular carcinoma (HCC) remained controversial, therefore, we assessed this associations by metaanalysis and trial sequential analysis (TSA). PubMed, Embase, Google Scholar, Chinese National Knowledge Infrastructure and Baidu Scholar were comprehensively screened to retrieve relevant studies up to May 20, 2019. A total of 32 studies was included. Significant associations were discovered in the overall and subgroup analysis in these three polymorphisms. Interestingly, the decreased risk of HCC was detected in the Indians for the rs24587 polymorphism. TSA indicated the required information size for the rs25487 polymorphism were reached, but for the rs25489 and rs1799782 polymorphisms, more well‐designed trials were required. Sensitivity analysis implied our results were stable; no publication bias was observed in the rs25487 and rs1799782 polymorphisms. The bioinformatic analysis indicate that the rs1799782 polymorphism is probably damaging and has an influence on the XRCC1 protein function. Our study indicated that the XRCC1 rs25487 was a risk factor for the susceptibility of HCC, which was verified by the TSA. In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC. In the subgroup analysis, increased risks were detected in some subgroups (in accordance with Hardy‐Weinberg equilibrium, Chinese groups, Mongoloid subgroup, polymerase chain reaction‐restriction fragment length polymorphisms and more than 300 subgroups), moreover, decreased HCC risk of the rs25487 polymorphism was firstly observed, which required further studies to verify.
TAZ promotes the proliferation and osteogenic differentiation of human periodontal ligament stem cells via the p‐SMAD3
Authors: Gu Ke , Fu Xucheng , Tian Hui , Zhang Yafei , Li Aonan , Wang Ying , Wen Yong , Gu Weiting 
Published: September 2019

AbstractObjectiveThis study aims to offer insights about the biological influence of TAZ, which is a transcriptional coactivator containing a PDZ‐binding motif, upon the apoptosis, proliferation, and osteogenic differentiation of human periodontal ligament stem cells (h‐PDLSCs).MethodsWe used the green fluorescence protein lentivirus infection system to knockdown or overexpress TAZ in h‐PDLSCs. 5‐ethynyl‐2’‐deoxyuridine (EdU) staining detected the proliferative activity, and h‐PDLSC apoptosis was analyzed by Annexin V‐APC staining. TAZ knockdown or overexpression was performed to determine the osteogenic differentiation function of TAZ during the osteogenic induction of h‐PDLSCs. The molecular mechanism of TAZ in the promotion of h‐PDLSC osteogenesis was also explored. The chemical inhibitor of SMAD2/3 SIS3 HCL was used to identify the effects in vitro osteogenic differentiation and bone formation in h‐PDLSCs overexpressing TAZ.ResultsTAZ overexpression resulted in enhanced cell rapid multiplication, which increased the expression of messenger RNA in stemness‐related genes. By comparison, TAZ knockdown reduced proliferative activity and increased the apoptosis of h‐PDLSCs. After the 7‐day osteogenic induction period, alkaline phosphatase activity in the TAZ‐overexpression group was significantly increased, and mineralized nodules increased significantly after osteogenic induction for 21 days. Similarly, osteoblast differentiation of h‐PDLSCs was impaired after TAZ knockdown. However, the osteogenic potential of the group exposed to the p‐SMAD3 inhibitor was restored to its original level.ConclusionHippo/TAZ plays a positive role inside the proliferation, stemness maintenance, and osteogenic specialization of h‐PDLSCs, and the specific downstream factor of osteogenic differentiation is SMAD3.
Serine peptidase inhibitor Kazal type III (SPINK3) promotes BRL‐3A cell proliferation by targeting the PI3K–AKT signaling pathway
Authors: Chang Cuifang , Xie Junjie , Yang Qingdan , Yang Jing , Luo Yaru , Xi Lingling , Guo Jianlin , Yang Ganggang , Jin Wei , Wang Gaiping 
Published: September 2019

AbstractThe serine protease inhibitor, Kazal type III (SPINK3), is a trypsin inhibitor associated with liver disease, which highly overexpresses in a variety of cancers. In one of our previous studies of our laboratory, Spink3 was observed to be significantly upregulated in rat liver regeneration (LR) via a gene expression profile. For the current study, rat hepatocyte BRL‐3A cells were treated by gene addition/interference, and the addition of the exogenous rat recombinant protein SPINK3. It was revealed that both the overexpression of endogenous Spink3 and addition of exogenous rat recombinant SPINK3 (rrSPINK3) significantly promoted the cell proliferation of BRL‐3A cells, whereas cell proliferation was inhibited when Spink3 was interfered. Furthermore, quantitative reverse transcription polymerase chain reaction and western blot results revealed that three signaling pathways, including extracellular‐signal‐regulated kinase 1/2 (ERK1/2), Janus kinase (JAK)–signal transducer and activator of transcription (STAT), and phosphatidylinositol‐3‐kinase (PI3K)–protein kinase B (AKT), as well as their related genes, were altered following endogenous Spink3 addition/interference. Also, the PI3K–AKT and SRC‐p38 pathways and their related genes were modified following exogenous SPINK3 treatment. Among them, the common signaling pathway was PI3K–AKT pathway. We concluded that SPINK3 could activate the PI3K–AKT pathway by enhancing the expression of AKT1 to regulate the proliferation of BRL‐3A cells. This study may contribute to shedding light on the potential mechanisms of SPINK3 that regulate the proliferation of BRL‐3A cells.
Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs
Authors: Podolska Malgorzata J , Mahajan Aparna , Hahn Jonas , Knopf Jasmin , Maueröder Christian , Petru Lenka , Ullmann Marc , Schett Georg , Leppkes Moritz , Herrmann Martin , Muñoz Luis E , Schauer Christine 
Published: September 2019

Abstract
The release of neutrophil extracellular traps (NETs) is one of the weapons neutrophils have in their armory. NETs consist of extracellular chromatin fibers decorated with a plethora of cytoplasmic and granular proteins, such as the antimicrobial serine protease neutrophil elastase (NE). Because the first description of NETs as beneficial to the host, reports on their double-faced role in health and disease have considerably increased recently. On one hand, NETs reportedly trap and kill bacteria and also participate in the resolution of the acute inflammation associated with infection and with tissue damage. On the other hand, numerous negative aspects of NETs contribute to the etiopathogenesis of autoimmune disorders. Employing soluble and solid fluorescent substrates, we demonstrate the interaction of NE with aggregated NETs (aggNETs), the limitation of its enzymatic activity and the containment of the enzyme from surrounding tissues. These events prevent the spread of inflammation and tissue damage. The detection of DNase 1-dependent elevation of NE activity attests the continuous presence of patrolling neutrophils forming NETs and aggNETs even under conditions physiologic conditions.
Parametric Presburger arithmetic: complexity of counting and quantifier elimination
Authors: Bogart Tristram , Goodrick John , Nguyen Danny , Woods Kevin 
Published: September 2019

AbstractWe consider an expansion of Presburger arithmetic which allows multiplication by k parameters . A formula in this language defines a parametric set as varies in , and we examine the counting function as a function of t. For a single parameter, it is known that can be expressed as an eventual quasi‐polynomial (there is a period m such that, for sufficiently large t, the function is polynomial on each of the residue classes mod m). We show that such a nice expression is impossible with 2 or more parameters. Indeed (assuming ) we construct a parametric set such that is not even polynomial‐time computable on input . In contrast, for parametric sets with arbitrarily many parameters, defined in a similar language without the ordering relation, we show that is always polynomial‐time computable in the size of t, and in fact can be represented using the gcd and similar functions.
Employment in refractory myasthenia gravis: A Myasthenia Gravis Foundation of America Registry analysis
Authors: Harris Linda , Aban Inmaculada B. , Xin Haichang , Cutter Gary 
Published: September 2019

AbstractIntroductionLabor‐market participation is potentially very difficult for patients with refractory myasthenia gravis (MG). In this study, employment status and work absences are compared between refractory and nonrefractory MG.MethodsAdults (aged 18–64 years, all diagnosed ≥2 years previously) were included if enrolled in the Myasthenia Gravis Foundation of America Patient Registry during July 2013 to February 2018.ResultsSeventy‐six patients (9.2%) had refractory and 749 (90.8%) had nonrefractory disease; demographic data did not differ between groups. Relative to the nonrefractory group, the refractory group patients were more than twice as likely to work fewer hours per week (odds ratio [95% confidence interval]: currently employed, 2.777 [1.640–4.704]; employed over previous 6 months, 2.643 [1.595–4.380]), but those employed were not more likely to be absent from work.DiscussionBecause absence from the labor market adversely affects quality of life and personal finances, these findings reaffirm the considerable disease burden associated with refractory MG.
Multiple scales analysis of the undular hydraulic jump over horizontal surfaces
Authors: Murschenhofer Dominik , Schneider Wilhelm 
Published: September 2019

AbstractThe basic equations for near‐critical stationary turbulent open‐channel flow over horizontal surfaces are solved by means of a multiple scales analysis. The multiple scales solution describing the first‐order perturbation of the free‐surface elevation is compared with the numerical solution of an extended steady‐state version of the Korteweg–de Vries (KdV) equation, confirming the uniform validity of this non‐linear third‐order ODE. In comparison with experimental data the numerical solution of the extended KdV equation shows strong dependence on the initial curvature in terms of wavelength and amplitude.
Does sperm DNA fragmentation correlate with semen parameters?
Authors: Le Minh Tam , Nguyen Tam An Thi , Nguyen Hiep Tuyet Thi , Nguyen Thai Thanh Thi , Nguyen Van Trung , Le Dinh Duong , Nguyen Vu Quoc Huy , Cao Ngoc Thanh 
Published: September 2019

AbstractPurposeThis study aimed to investigate the association between sperm quality assessed by routine semen analysis and sperm DNA integrity assay.MethodsIn our cross‐sectional study, a total of 318 men from the infertile couples were enrolled from December 2017 to March 2019 at the Hue Center for Reproductive Endocrinology and Infertility, Vietnam. General characteristics and semen parameters were detected. The sperm DNA fragmentation index (DFI) was estimated by the sperm chromatin dispersion (SCD) assay. A threshold of DFI 30% was applied to classify normal (DFI < 30%) or abnormal (DFI ≥ 30%) groups. The correlations between DFI and semen parameters were analyzed by Spearman's rank correlation coefficient.ResultsIn the correlation analysis, DFI was significantly correlated with abnormal head and progressive motility, with a positive correlation with abnormal head (ρ = .202, P = .0003) and a weak negative correlation with progressive motility (ρ = −.168, P = .0027), respectively. In the bivariate analysis, DFI was associated with male age, smoking, and alcohol consumption with P < .05.ConclusionsThe sperm DFI was not strongly correlated with conventional semen parameters. Therefore, a sperm DNA fragmentation assay should be performed as an additional step in the investigation of male fertility.