bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad Temperature Plateau for High Piezoelectric Coefficient by Embedding PNRs in Singe‐Phase KNN‐Based Ceramics
Authors: Hua Yin , Qian Jin , Yang Yuxuan , Wang Simin , Ge Guanglong , Zhang Yang , Lin Jimin , Lin Jinfeng , Wu Haijun , Li Fei , Zhai Jiwei 
Published: October 2024

AbstractTo date, the enormous potential of lead‐free piezoceramics in ultrasonic transducers and micro‐actuators has driven extensive research and development. Although the piezoelectric coefficient (d33) of lead‐free ceramics is improved unprecedentedly, the breakthrough in comprehensive performance is still a key issue, one of which is the inverse relationship between d33 and Curie temperature (TC), and the other is the temperature stability of piezoelectricity. Here, based on the synergistic optimization of the chemical component modulation and texture technology, the high Curie temperature (≈365 °C), high piezoelectric properties (d33 ≈331 pC/N, d33* ≈561 pm V−1) and advanced piezoelectric temperature stability are realized by embedded PNRs in the conceived and prepared lead‐free single phase 0.96((K0.5Na0.5)(Nb0.98Ta0.02)O3)‐0.01(Bi(Ni0.67Nb0.33)O3)‐0.03(Bi0.5K0.5)HfO3 texture ceramics. The d33 changes by only 2.0% when the temperature is increased from 25 to 100 °C (≈10.0% to 200 °C), while the electrical strain (d33*) changes by only 4.2% when the temperature is increased from 25 to 175 °C (≈9.8% to 200 °C), which is comparable to the commercial lead‐based materials (i.e., PZT‐4). This work demonstrates significant progress in the comprehensive piezoelectric performance (especially the piezoelectric temperature stability) of lead‐free ceramics and inspires further attempts to achieve high‐temperature piezoelectric properties.
MHz High Performance of Soft Magnetic Composite with Ordered Domain Structure for Efficient Conversion of Electrical Energy
Authors: Jin Xiaowei , Li Tong , Yao Yuping , Wang Chaojie , Shi Huigang , Chai Guozhi , Gao Daqiang , Jia Chenglong , Xi Li , Xue Desheng 
Published: October 2024

AbstractSoft magnetic materials are a core element of power electronics and electrical machines. However, none of the soft magnetic materials is able to exploit the full potential of wide bandgap semiconductors, which operate above MHz frequency for efficient energy conversion in power electronic systems. Here, a high‐performance Fe–Si soft magnetic composites with a 2D ordered domain structure are reported, enabling efficient energy conversion at MHz frequencies. By transforming spherical particles into flakes and arranging them in layers, 2D magnetic domains are created within the composite. This leads to a 90% increase in permeability and a tenfold decrease in loss at 3 MHz compared to composite made with spherical particles. The significantly increased cut‐off frequency indicates that the ordered flaky particles are suitable for MHz applications, unlike the disordered spherical particles. These findings provide an effective approach for fabricating high performance soft magnetic composites from traditional spherical particles and miniaturizing magnetic devices for efficient power electronics operation.
Prussian Blue‐Derived Atomic Fe/Fe3C@N‐Doped C Catalysts Supported by Carbon Cloth as Integrated Air Cathode for Flexible Zn‐Air Batteries
Authors: Wang Zihan , Ren Jing , Ling Guoqiang , Guo Junjie , Lv Yongkang , Ren Rui‐Peng 
Published: October 2024

AbstractThe development of an integrated air cathode with superior oxygen reduction reaction (ORR) performance is fundamental to flexible zinc‐air batteries (ZABs) for wearable electronics. Herein, a self‐assembled metal‐organic framework (MOF)‐derived strategy is proposed to prepare a atomic Fe/Fe3C@N‐doped C catalysts supported by carbon cloth (CC) catalyst for use as an air cathode of flexible ZABs. The Prussian Blue precursor, which self‐assembles on the surface of the carbon cloth due to electrostatic attraction, is critical in achieving the uniform dispersion of catalysts with high density loading on carbon cloth substrates. The hollow cubic structure, N‐doped carbon layer coating, and the integrated electrode design can provide more accessible active sites and facilitate a rapid electron transfer and mass transport. Density functional theory (DFT) calculation reveals that the electronic interactions between the Fe‐N4 and Fe3C dual active sites can optimize the adsorption‐desorption behavior of oxygen intermediates formed during the ORR. Consequently, the Fe/Fe3C@N‐doped C/CC exhibits an excellent half wave potential (E1/2 = 0.903 V) and superior long‐term cycling stability in alkaline environments. With excellent ORR performance, ZABs and flexible ZABs based on Fe/Fe3C@N‐doped C/CC air cathode demonstrate excellent overall electrochemical performance in terms of open circuit voltage, maximum power density, flexibility, and cycling stability.
From Lab to Life: Self‐Powered Sweat Sensors and Their Future in Personal Health Monitoring
Authors: Gao Nan , Xu Guodong , Chang Gang , Wu Yuxiang 
Published: October 2024

AbstractThe rapid development of wearable sweat sensors has demonstrated their potential for continuous, non‐invasive disease diagnosis and health monitoring. Emerging energy harvesters capable of converting various environmental energy sources—biomechanical, thermal, biochemical, and solar—into electrical energy are revolutionizing power solutions for wearable devices. Based on self‐powered technology, the integration of the energy harvesters with wearable sweat sensors can drive the device for biosensing, signal processing, and data transmission. As a result, self‐powered sweat sensors are able to operate continuously without external power or charging, greatly facilitating the development of wearable electronics and personalized healthcare. This review focuses on the recent advances in self‐powered sweat sensors for personalized healthcare, covering sweat sensors, energy harvesters, energy management, and applications. The review begins with the foundations of wearable sweat sensors, providing an overview of their detection methods, materials, and wearable devices. Then, the working mechanism, structure, and a characteristic of different types of energy harvesters are discussed. The features and challenges of different energy harvesters in energy supply and energy management of sweat sensors are emphasized. The review concludes with a look at the future prospects of self‐powered sweat sensors, outlining the trajectory of the field and its potential to flourish.
Rh(III)‐Catalyzed Annulation of (Het)aryl Amides with α‐Allenyl‐Containing α‐Amino Acid Derivatives
Authors: Vorobyeva Daria V. , Bubnova Alexandra S. , Godovikov Ivan A. , Smol'yakov Alexander F. , Osipov Sergey N. 
Published: October 2024

AbstractAn efficient pathway to a new series of CF3‐substituted α‐amino acid derivatives decorated with pharmacophore isoquinolone and pyrimido[1,6‐a]indolone cores has been developed. The method includes Rh(III)‐catalyzed C−H activation/[4+2]‐annulation of N‐(pivaloyloxy)‐substituted aryl hydroxamates and indole‐1‐carboxamides with readily available allenyl‐containing α‐amino carboxylates and their phosphorus analogues. It was established that the reactions occur via Rh‐σ‐alkenyl intermediates to provide new C−C bond forming process with the participation of terminal carbon atom of allene moiety.
Clinical Issues — November 2024
Authors: Swartz Zach 
Published: October 2024

THIS MONTH
Reducing the perioperative carbon footprint
Key words: sustainability, carbon footprint, greenhouse gas (GHG), energy, consumption.
Exsanguination before tourniquet use
Key words: elastic wrap, exsanguination, gravity, pneumatic tourniquet, limb.
Using augmented reality technology in the OR
Key words: augmented reality (AR), virtual reality (VR), extended reality (XR), headset, navigation.
Patients wearing contact lenses during a procedure
Key words: contact lens, corneal abrasion, patient positioning, eye injury, risk factors.
A cadaveric study showing the OLIF corridor dimensions after retraction of the abdominal great arteries and psoas major
Authors: Deng Donghai , Liao Xuqiang , Wu Ruihui , Zhou Yunfei , Huang Xingqiu , Shi Chenglong , Min Shaoxiong , Shi Benchao 
Published: October 2024

AbstractThe aim of this study is to assess the oblique lateral interbody fusion (OLIF) corridor dimensions when the abdominal great arteries (the abdominal aorta or common iliac arteries) and psoas major are retracted. Twenty embalmed cadaveric specimens were dissected. The widths of the OLIF operative corridor at L1‐2, L2‐3, L3‐4, and L4‐5 were measured with the psoas major and abdominal great arteries in static state, with psoas retraction, and with mild retraction of the abdominal great arteries. The retractable distances of the psoas major and the abdominal great arteries at each lumbar segment were compared. In the static state, the operative corridor gradually narrowed from L1‐2 to L4‐5, but there was no significant difference in its width between segments (p > 0.05). There was no significant difference in the corridor width between segments after retraction of the psoas major or the abdominal great arteries (p > 0.05). However, retraction of either the psoas major or the abdominal great arteries made the corridor at the L1‐5 segments significantly wider than those in the static state (p < 0.05), particularly at L4‐5, and the retractable distance of the psoas major was significantly greater (p < 0.05). The cadaveric model demonstrated the use of abdominal great arteries retraction in principle. The OLIF operative corridor could be widened to some extent by retracting the abdominal great arteries, and widened further by retracting the psoas major.
Immunotherapy Vaccines for Prostate Cancer Treatment
Authors: He Jide , Wu Jialong , Li Ziang , Zhao Zhenkun , Qiu Lei , Zhu Xuehua , Liu Zenan , Xia Haizhui , Hong Peng , Yang Jianling , Ni Ling , Lu Jian 
Published: October 2024

ABSTRACTBackgroundTherapeutic tumor vaccines have emerged as a compelling avenue for treating patients afflicted with advanced prostate cancer (PCa), particularly those experiencing biochemical relapse or ineligible for surgical intervention. This study serves to consolidate recent research findings on therapeutic vaccines targeting prostate tumors while delineating prevalent challenges within vaccine research and development.MethodsWe searched electronic databases, including PubMed, Web of Science, Embase, and Scopus, up to August 31, 2024, using keywords such as 'vaccine', 'prostate cancer', 'immunotherapy', and others. We reviewed studies on various therapeutic vaccines, including dendritic cell‐based, antigen, nucleic acid, and tumor cell vaccines.ResultsStudies consistently showed that therapeutic vaccines, notably DC vaccines, had favorable safety profiles with few adverse effects. These vaccines, with varied antigenic formulations, demonstrated strong clinical outcomes, as indicated by metrics such as PSA response rates (9.5%‐58%), extended PSA doubling times (52.9%–89.7%), overall survival durations (17.7–33.8 months), two‐year mortality rates (0%–12.5%), biochemical relapse rates (42%–73%), and antigen‐specific immune responses (33.3%–71.4% in responsive groups).ConclusionWhile clinical data for tumor vaccines have illuminated robust evidence of tumoricidal activity, the processes of their formulation and deployment are riddled with complexities. Combining vaccines with other therapies may enhance outcomes, and future research should focus on early interventions and deciphering the immune system's role in oncogenesis.
School staff perceptions of the impact of school counselling on young people, the school and integration into the school system
Authors: O'Donnell Jennifer , Sumner Amy Louise , Smith Stephanie , Eilenberg Jon , Duncan Charlie , Cooper Mick 
Published: October 2024

AbstractIntroductionThis research explored the views of staff in secondary schools on school counselling for young people. Data were drawn from the Effectiveness and Cost Effectiveness Trial of Humanistic Counselling in Schools (ETHOS) study, an RCT of school counselling across 18 state‐funded secondary schools in London.MethodsQualitative semi‐structured interviews were held with school staff (n = 16) from a sub‐sample of 10 participating schools from the RCT. The interviews explored the perceived impact of school counselling on the school and students. Thematic analysis was conducted using the NVivo qualitative data analysis software.ResultsThree key themes were identified: (1) school context: rising mental health need and varying provision for mental health; (2) school staff perspectives on the impact of counselling: increased openness and improvements in mood, dedicated space to open up, putting skills into practice, one size does not fit all, and role of personal connection; and (3) long‐term impact of counselling in schools: integration as central to success and counselling as a stepping stone for further support.ConclusionThis research provides insights into school staff views of secondary school counselling in the context of delivery through a research trial. Effective ways of integrating counselling services into schools are identified.
Dynamic pH‐Responsive Release and Biological Impact of In Situ Quercetin‐Modified MIL‐101(Fe)‐NH2
Authors: Alya Nabilah Ghina , Adi Nugroho Roshid , Dendy Dendy , Handayani Murni , Sukowati Caecilia , Tiribelli Claudio , Lory Crocè Saveria , Wahyu Lestari Witri 
Published: October 2024

AbstractA successful investigation was conducted on the in situ modification of MIL‐101(Fe)‐NH2 with quercetin and its controlled release under various pH conditions. MIL‐101(Fe)‐NH2 was synthesized using an electrochemical method at room temperature (15 volts, 30 min). The formation of the material was confirmed through comprehensive analyses, including PXRD, FTIR, and TGA. Nitrogen sorption isotherm measurements revealed that Qu@MIL‐101(Fe)‐NH2 exhibited a smaller surface area compared to MIL‐101(Fe)‐NH2, with both materials classified as mesoporous. Transmission electron microscopy (TEM) clearly depicted the materials’ octahedral microspindle morphology. The cumulative percent release (CPR) of quercetin from Qu@MIL‐101(Fe)‐NH2 over 72 h was determined to be 53.45 % at pH 1.2, 19.48 % at pH 4.8, and 5.87 % at pH 7.4. Notably, quercetin release in the acidic microenvironment representative of cancer cells (pH 4.8) was nearly four times higher than under physiological conditions (pH 7.4). Kinetic release studies indicated that quercetin release from Qu@MIL‐101(Fe)‐NH2 followed the Ritger‐Peppas kinetic model, suggesting non‐Fickian diffusion. The MIL‐101(Fe)‐NH2 nanocarriers, with in situ‐loaded quercetin, demonstrated promising potential for pH‐triggered drug release. Additionally, the safety of MIL‐101(Fe)‐NH2 in biological models and the anticancer efficacy of quercetin were evaluated in vitro using two liver cancer cell lines.
Assessing the Concordance of Clinical and Pathological Diagnoses in Basal Cell Carcinoma Among the Iranian Population: A Cross‐Sectional Analysis of 229 Cases
Authors: Farshad Fatemeh , Behrangi Elham , Jafarzadeh Alireza , Roohaninasab Masoumeh , Shayanfar Nasrin , Aryanian Zeinab , Hatami Parvaneh , Goodarzi Azadeh 
Published: October 2024

ABSTRACTBackgroundNonmelanoma skin cancer (NMSC) is the most prevalent malignancy globally, with basal cell carcinoma (BCC) being the most common type.AimsThis study aims to evaluate the concordance between clinical and pathological diagnoses of BCC, emphasizing the importance of early detection.Methods and ResultsIn this cross‐sectional study, we conducted a retrospective review of clinical and pathological records for 229 patients diagnosed with BCC between 2020 and 2024. The analysis focused on gender, age, lesion location, and diagnostic accuracy. Among the 229 patients, 193 were men (84.3%), and 131 (57.2%) had recorded clinical diagnoses. The mean age of diagnosed patients was 67.72 years. Lesions were primarily located on the scalp (29.5%), face (26.4%), and nose (13.9%). Of the pathological evaluations, 184 cases (80.3%) confirmed BCC, while 45 cases had alternative diagnoses. Notably, 94.6% of clinically diagnosed patients were suspected to have BCC by their physicians. A significant portion of cases (42%) lacked prior clinical diagnoses, reflecting a potential gap in education among nondermatologists regarding BCC recognition.ConclusionThe study found high concordance between clinical and pathological diagnoses of BCC, underscoring the need for improved clinical assessment skills among healthcare providers. Collaboration with dermatologists is essential for accurate diagnosis and improved patient outcomes. Enhanced training in recognizing BCC symptoms is recommended to address the identified gaps in clinical suspicion.
Potential Blind Spots and Hot Spots for Nutrient Loss
Authors: Korzekwa Kaine 
Published: October 2024

AbstractThe application and fate of nutrients are two of the biggest questions agriculture faces today, affecting everything from profit margins to water quality. Researchers work to examine the issue from all angles, such as the kinds of fertilizers widely used in the United States to how the topography of a field can impact the distribution and runoff of nutrients. In this article, we look at two recent research articles that approach these questions from different angles. One sees the nitrogen content of ammonium phosphate fertilizers as a “blind spot” in nitrogen budgets. The other sees farmed prairie potholes as potential “hot spots” for nutrient runoff downstream. Earn 1 CEU in Nutrient Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
OMIP‐109: 45‐color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment
Authors: Park Lily M. , Lannigan Joanne , Low Quentin , Jaimes Maria C. , Bonilla Diana L. 
Published: October 2024

AbstractThe need for more in‐depth exploration of the human immune system has moved the flow cytometry field forward with advances in instrumentation, reagent development and availability, and user‐friendly implementation of data analysis methods. We developed a high‐quality human 45‐color panel, for comprehensive characterization of major cell lineages present in circulation including T cells, γδ T cells, NKT‐like cells, B cells, NK cells, monocytes, basophils, dendritic cells, and ILCs. Assay optimization steps are described in detail to ensure that each marker in the panel was optimally resolved. In addition, we highlight the outstanding discernment of cell activation, exhaustion, memory, and differentiation states of CD4+ and CD8+ T cells using this 45‐color panel. The panel enabled an in‐depth description of very distinct phenotypes associated with the complexity of the T cell memory response. Furthermore, we present how this panel can be effectively used for cell sorting on instruments with a similar optical layout to achieve the same level of resolution. Functional evaluation of sorted specific rare cell subsets demonstrated significantly different patterns of immunological responses to stimulation, supporting functional and phenotypic differences within the T cell memory subsets. In summary, the combination of full spectrum profiling technology and careful assay design and optimization results in a high resolution multiparametric 45‐color assay. This panel offers the opportunity to fully characterize immunological profiles present in peripheral blood in the context of infectious diseases, autoimmunity, neurodegeneration, immunotherapy, and biomarker discovery.
Trends in heart failure mortality in Sweden between 1997 and 2022
Authors: Lindberg Felix , Benson Lina , Dahlström Ulf , Lund Lars H. , Savarese Gianluigi 
Published: October 2024

AbstractAimsData from US have shown a reversal in the improvement of heart failure (HF)‐related mortality over the last ~10 years. It is unknown whether these trends generalize to European universal healthcare systems. We assessed temporal trends in (i) HF‐related mortality in the overall national population; and (ii) all‐cause mortality following an incident HF diagnosis, overall and stratified by ejection fraction (EF), in Sweden between 1997 and 2022.Methods and resultsAnnual mortality rates with a HF diagnosis as underlying cause were extracted from the Cause of Death Register. All‐cause mortality following incident HF was assessed in two HF cohorts derived from the National Patient Register (NPR) and the Swedish HF Registry (SwedeHF). Temporal trends were presented as average annual percentage change (AAPC). Between 1997 and 2022, age‐adjusted HF‐related mortality in the general population declined from 33.4 to 23.8 per 100 000 individuals (AAPC −2.15%, p < 0.001). In the HF cohort from NPR (n = 423 092), all‐cause mortality at 1, 3, and 5 years following a first diagnosis of HF was 25%, 46%, and 58%, respectively, in 2022; 1‐year mortality declined (AAPC −1.10%, p < 0.001) over time regardless of age or sex. In SwedeHF (n = 63 753), the decline in 1‐year mortality was less steep with increasing EF (AAPC −2.64%, p < 0.001; −2.30%, p = 0.062; and −2.16%, p = 0.032 in EF <40%, 40–49%, and ≥50%, respectively).ConclusionsHeart failure‐related mortality has declined over the last ~25 years in Sweden. All‐cause mortality in patients with HF has also declined, more in HF with reduced than preserved EF, mirroring the different availability of life‐saving treatments across the EF spectrum.
The Influence of Anthropometric Factors on Renal mpMRI: Insights From Regional Analysis
Authors: Sanmiguel Serpa Luis Carlos , de Visschere Pieter , Speeckaert Marijn , Pullens Pim 
Published: October 2024

BackgroundMultiparametric MRI (mpMRI) provides detailed insights into renal function, but the impact of anthropometric factors on renal imaging is not fully understood.PurposeTo investigate regional correlations between mpMRI parameters and age, body mass index (BMI), and body surface area (BSA).Study TypeProspective, cross‐sectional observational study.PopulationTwenty‐nine healthy volunteers (44.5 ± 18.3 years, 18 females) without a history of renal disease.Field Strength/Sequence3‐T, pseudo‐continuous arterial spin labeling, multi‐echo gradient‐recalled echo, diffusion‐weighted imaging, T1 and T2 mapping.AssessmentBilateral kidneys were segmented into nine concentric layers (outer cortex to inner regions) and nine equiangular sections (lower to upper pole). Key parameters (renal blood flow [RBF], , apparent diffusion coefficient [ADC], T1 and T2 maps) were correlated with age, BMI, and BSA. Differences in parameters between age and BMI groups were also evaluated.Statistical TestsSpearman correlation, Mann–Whitney U test, and rank‐biserial correlation coefficient for effect size. A P‐value <0.05 was considered statistically significant.ResultsRBF correlated negatively with age in all regions and BMI in inner layers and lower pole. ADC negatively correlated with BMI (significance was not reached in layers 2, 7, 8; P‐value = 0.06–0.12) and BSA in layers 1–7. T1 negatively correlated with age in inner regions and lower medial pole. Significant positive correlations were found between age and (outermost layer, upper pole), age and T2 (inner and cranial‐caudal regions), as well as BMI and T2 (except upper pole; P‐value = 0.06). Significant differences between age groups were observed for RBF (all regions), (outermost and second innermost layers, central lateral region), T1 (innermost layer), and T2 (upper medial pole). Between BMI groups, ADC (middle layers, upper medial pole) and T2 (outermost and inner layers, lower pole to lateral region) differed significantly.Data ConclusionIntrarenal variance of mpMRI parameters correlated with age, BMI, and BSA.Evidence Level4Technical EfficacyStage 1