bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Choices for Continuing Education: A Statewide Survey of the Practices and Preferences of Nurse Practitioners
Authors: Charles Patricia A , Mamary Edward M 
Published: January 2019

ABSTRACT
Technological innovations in the past decade have made possible several promising new modes for delivering continuing education (CE). Offering a wide variety of educational approaches is necessary to satisfy the different learning needs and preferences of program participants. Continuing education planners need to assess the preferences and practices of Advanced Practitioners of Nursing (AFNs) when choosing the modes they will offer for delivering CE programs. A survey was conducted with the entire population of licensed APNs in Nevada to assess practices, preferences, and barriers to use of various CE delivery modes. In-person conferences and live satellite conferences were the most frequently used methods. The top three preferences/ in rank order, were in-person conference, print-based self-study, and interactive video conference. Live satellite conference was the least preferred method of earning CE credits. Computer-based modes of CE delivery, which include the Internet and CD-ROM, were among the least used. Findings from this study provide useful information for planners of CE programs for APNs. Data acquired in this study also address the dearth of information related to computer use by APNs for obtaining CE.
Characterization of Subpopulations of Chicken Mononuclear Phagocytes That Express TIM4 and CSF1R
Authors: Hu Tuanjun , Wu Zhiguang , Bush Stephen J. , Freem Lucy , Vervelde Lonneke , Summers Kim M. , Hume David A. , Balic Adam , Kaiser Pete 
Published: January 2019

Abstract
The phosphatidylserine receptor TIM4, encoded by TIMD4, mediates the phagocytic uptake of apoptotic cells. We applied anti-chicken TIM4 mAbs in combination with CSF1R reporter transgenes to dissect the function of TIM4 in the chick (Gallus gallus). During development in ovo, TIM4 was present on the large majority of macrophages, but expression became more heterogeneous posthatch. Blood monocytes expressed KUL01, class II MHC, and CSF1R-mApple uniformly. Around 50% of monocytes were positive for surface TIM4. They also expressed many other monocyte-specific transcripts at a higher level than TIM4− monocytes. In liver, highly phagocytic TIM4hi cells shared many transcripts with mammalian Kupffer cells and were associated with uptake of apoptotic cells. Although they expressed CSF1R mRNA, Kupffer cells did not express the CSF1R-mApple transgene, suggesting that additional CSF1R transcriptional regulatory elements are required by these cells. By contrast, CSF1R-mApple was detected in liver TIM4lo and TIM4− cells, which were not phagocytic and were more abundant than Kupffer cells. These cells expressed CSF1R alongside high levels of FLT3, MHCII, XCR1, and other markers associated with conventional dendritic cells in mice. In bursa, TIM4 was present on the cell surface of two populations. Like Kupffer cells, bursal TIM4hi phagocytes coexpressed many receptors involved in apoptotic cell recognition. TIM4lo cells appear to be a subpopulation of bursal B cells. In overview, TIM4 is associated with phagocytes that eliminate apoptotic cells in the chick. In the liver, TIM4 and CSF1R reporters distinguished Kupffer cells from an abundant population of dendritic cell–like cells.
Characteristics of peripheral immune cell subsets in patients with carotid atherosclerosis undergoing carotid endarterectomy
Authors: Kotfis Katarzyna , Biernawska Jowita , Zegan-Barańska Małgorzata , Gutowski Piotr , Żukowski Maciej 
Published: January 2019

IntroductionThe role of circulating immune cells in the pathophysiology of cerebrovascular accidents is currently under debate. The aim of this study was to characterize peripheral immune cell subsets in patients undergoing carotid endarterectomy (CEA).Material and methodsWe conducted a prospective observational study in a group of 124 patients with significant carotid stenosis undergoing carotid endarterectomy, both symptomatic and asymptomatic. We compared the percentages of circulating immune cells: B lymphocytes, T lymphocytes, T helper, cytotoxic T, CD4+/CD8+ ratio, T regulatory, monocytes and NK cells before CEA and 6 h after the procedure.ResultsTotal lymphocyte count and cytotoxic T lymphocyte count decreased 6 h after CEA in both subgroups. The NK cell level decrease was statistically significant only in the symptomatic subgroup (19.41 ±9.30 before CEA and 16.52 ±9.37 after CEA; p = 0.0044), but not in the asymptomatic subgroup (17.88 ±9.14 before CEA and 15.91 ±9.51 after CEA; p = 0.0886). The T lymphocyte level showed a statistically significant increase only in symptomatic patients (69.74 ±10.16 before CEA vs. 71.45 ±9.77 after CEA; p = 0.0462), and not in the asymptomatic subgroup (70.08 ±11.19 prior to CEA and 70.21 ±12.35; p = 0.9048). B lymphocyte, helper T lymphocyte and regulatory T (Treg) lymphocyte (CD4+/CD25+) levels showed a significant increase after CEA.ConclusionsThis is the first study to compare circulating immune cells in patients undergoing carotid endarterectomy. Only the symptomatic subgroup experienced a significant decrease in the NK cell level and an increase in the T lymphocyte count after CEA. This study enriches our understanding of immune cell kinetics during carotid endarterectomy.
Autogenously derived regenerative cell therapy for venous leg ulcers
Authors: Kavala Ali , Turkyilmaz Saygin 
Published: January 2019

IntroductionVenous leg ulcers (VLUs), which arise from chronic venous insufficiency in the lower limbs, are a major cause of morbidity and significantly negatively impact patients’ health-related quality of life. Treatment of venous ulcers can be either conservative or surgical. Despite appropriate treatment, VLUs can be resistant to healing. Clinical results of treatment of venous foot ulcers with adipose-derived autologous stem cells, which did not improve despite the surgical treatment of the underlying venous pathology in the following case series, are reported.Material and methodsBetween April 2015 and January 2016, a total of 31 patients who had undergone surgery for underlying venous pathology but the venous ulcer had not healed were included in the study. The mean venous ulcer size was 3.6–6.2 cm (range: 2 to 8 cm by 3 to 9 cm). All patients were treated with adipose-derived autologous stem cells prepared using the MyStem Regenerative Adipose-Derived Stem Cell Purification Kit (MyStem LLC, USA). The ulcer diameter was measured and recorded in the third, sixth and twelfth months. The follow-up time was 12 months after ulcer healing.ResultsEighteen ulcers demonstrated complete healing at the 12th month. Thirteen ulcers exhibited serious contraction and epithelialization even though the ulcer was not completely closed. At the 12th month, the ulcer size was reduced by 96.00 ±1.74% in these patients. The reduction in the ulcer area based on the month analyzed was significant (p = 0.001; p < 0.01). After the ulcers healed, the patients were followed for recurrence for one year. Recurrent ulcers were observed at the treated sites in 3 of 31 patients (9%). No adverse events, such as infection, inflammation, or tissue reactions, were observed.ConclusionsApplication of cell therapy in venous leg ulcer is currently used exclusively in patients not responding to the standard treatment. Autogenously derived regenerative cell therapy for VLUs can be considered as an additional treatment to primary surgical therapy.
The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study
Authors: Khorshied Mervat , Ibrahim Ola , Gad Alaa , El-Ghamrawy Mona 
Published: January 2019

IntroductionSickle cell disease (SCD) is a chronic inflammatory disorder characterized by altered levels of several inflammatory cytokines, which may be regulated by genetic polymorphisms and could be associated with diverse clinical presentations. Interleukin 1β (IL-1) and interleukin 6 (IL-6) have a pivotal role in the pathogenesis of many acute and chronic diseases, and their genetic alterations have been considered as molecular contributors to several inflammatory disorders. The current study aimed to define the impact of IL-1β and IL-6 genetic polymorphisms on the clinical course of the disease in a cohort of pediatric SCD patients.Material and methodsGenotyping of IL-1β +3954 C/T and IL-6 –174 G/C polymorphisms was performed by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique for 84 SCD patients and 100 age- and gender-matched unrelated healthy controls.ResultsThe polymorphic genotypes of IL-6 –174 G/C were associated with patients suffering from repeated, severe attacks of vaso-occlusion (VOC) requiring hospitalization (p = 0.023 and p = 0.03 respectively), while no significant differences were noted between SCD patients harboring the wild or the polymorphic genotypes of IL-1β +3954 C/T and their demographic, clinical or laboratory characteristics.ConclusionsIL-6 –174 G/C polymorphism could be considered as a molecular predictor for recurrent, severe attacks of vascular occlusion in Egyptian SCD patients. Considering the important roles of cytokines in SCD pathophysiology, further investigations in larger cohorts are recommended for better characterization of individual variations in immune regulatory genes and identification of novel markers for disease complications and morbidity.
Blackness and the Pitfalls of Anthropocene Ethics
Authors: Karera Axelle 
Published: January 2019

Abstract
Though to deny the geological impact of human force on nature is now essentially quasi-criminal, many theorists (mostly in the humanities) remain, nonetheless, unimpressed with what this “new era” has afforded us in terms of critical potential. This article is concerned with what Srinivas Aravamudan deems “the escapist philosophy of various dimension of the hypothesis concerning the Anthropocene.” Following Erik Swyngedouw's indictment of apocalyptic discourses' vital role in displacing social antagonisms and nurturing capitalism, this article argues that the new regimes of Anthropocenean consciousness have been powerful in disavowing racial antagonisms. It discusses the ways in which Anthropocene ethics have foreclosed proper political framings by promoting a moral philosophy unequipped to face the racial histories of our current ecological predicament. It contends that the “political Anthropocene” (if there is or ought to be one) will remain an impossibility until it is able to wrestle with the problem of black suffering.
Jewels and Ladders: Visualizing and Resisting the Racialization and Dehumanization of E/Im-migrants and Refugees
Authors: Ortiz John Kaiser 
Published: January 2019

AbstractWhile attending seminary school in Pennsylvania, Martin Luther King Jr. cultivated “the arts of pulpit oratory,” the habit of visualizing philosophical problems and other objects of criticism by invoking many-sided jewels and multi-runged ladders. This article appropriates King's jewels and ladders as tools for humanizing juridico-discursive practice toward migrants/emigrants/immigrants and refugees. By drawing attention to the process whereby persons are subordinated and become subpersons, we are able to see how the standpoint of racialized dehumanization is historically patterned and furthermore involves an overlap of legal, political, and artistic expressions. Consequently, jewels and ladders become theoretical as well as practical tools for visualizing the moral standing of migrant/refugee populations in modernity.
Computational Developmental Psychology
Authors: Shultz Thomas R. 
Published: January 2019

An overview of the emerging discipline of computational developmental psychology, emphasizing the use of constructivist neural networks.
Despite decades of scientific research, the core issues of child development remain too complex to be explained by traditional verbal theories. These issues include structure and transition, representation and processing, innate and experiential determinants of development, stages of development, the purpose and end of development, and the relation between knowledge and learning. In this book Thomas Shultz shows how computational modeling can be used to capture these complex phenomena, and in so doing he lays the foundation for a new subfield of developmental psychology, computational developmental psychology.
A principal approach in developmental thinking is the constructivist one. Constructivism is the Piagetian view that the child builds new cognitive structures by using current mental structures to understand new events. In this book Shultz features constructivist models employing networks that grow as well as learn. This allows models to implement synaptogenesis and neurogenesis in a way that allows qualitative changes in processing mechanisms. The book's appendices provide additional background on the mathematical concepts used, and a companion Web site contains easy-to-use computational packages.
Bradford Books imprint
Globalization and the Poor Periphery before 1950
Authors: Williamson Jeffrey G. 
Published: January 2019

A leading authority on economic globalization argues that industrialization in the core countries of northwest Europe and its overseas settlements combined with a worldwide revolution in transportation to produce deindustrialization and an antiglobal backlash in industrially lagging poorer countries.
In Globalization and the Poor Periphery before 1950 Jeffrey Williamson examines globalization through the lens of both the economist and the historian, analyzing its economic impact on industrially lagging poor countries in the nineteenth and early twentieth centuries. Williamson argues that industrialization in the core countries of northwest Europe and their overseas settlements, combined with a worldwide revolution in transportation, created an antiglobal backlash in the periphery, the poorer countries of eastern and southern Europe, the Middle East, Africa, Asia, and Latin America.
During the "first global century," from about 1820 to 1913, and the antiglobal autarkic interwar period from 1914 to 1940, new methods of transportation integrated world commodity markets and caused a boom in trade between the core and the periphery. Rapid productivity growth, which lowered the price of manufactured goods, led to a soaring demand in the core countries for raw materials supplied by the periphery. When the boom turned into bust, after almost a century and a half, the gap in living standards between the core and the periphery was even wider than it had been at the beginning of the cycle. The periphery, argues Williamson, obeyed the laws of motion of the international economy. Synthesizing and summarizing fifteen years of Williamson's pioneering work on globalization, the book documents these laws of motion in the periphery, assesses their distribution and growth consequences, and examines the response of trade policy in these regions.
Reconstructing the Cognitive World
Authors: Wheeler Michael 
Published: January 2019

In Reconstructing the Cognitive World, Michael Wheeler argues that we should turn away from the generically Cartesian philosophical foundations of much contemporary cognitive science research and proposes instead a Heideggerian approach. Wheeler begins with an interpretation of Descartes. He defines Cartesian psychology as a conceptual framework of explanatory principles and shows how each of these principles is part of the deep assumptions of orthodox cognitive science (both classical and connectionist). Wheeler then turns to Heidegger's radically non-Cartesian account of everyday cognition, which, he argues, can be used to articulate the philosophical foundations of a genuinely non-Cartesian cognitive science. Finding that Heidegger's critique of Cartesian thinking falls short, even when supported by Hubert Dreyfus's influential critique of orthodox artificial intelligence, Wheeler suggests a new Heideggerian approach. He points to recent research in "embodied-embedded" cognitive science and proposes a Heideggerian framework to identify, amplify, and clarify the underlying philosophical foundations of this new work. He focuses much of his investigation on recent work in artificial intelligence-oriented robotics, discussing, among other topics, the nature and status of representational explanation, and whether (and to what extent) cognition is computation rather than a noncomputational phenomenon best described in the language of dynamical systems theory.
Wheeler's argument draws on analytic philosophy, continental philosophy, and empirical work to "reconstruct" the philosophical foundations of cognitive science in a time of a fundamental shift away from a generically Cartesian approach. His analysis demonstrates that Heideggerian continental philosophy and naturalistic cognitive science need not be mutually exclusive and shows further that a Heideggerian framework can act as the "conceptual glue" for new work in cognitive science.
Bradford Books imprint
Varieties of Meaning
Authors: Millikan Ruth Garrett 
Published: January 2019

Many different things are said to have meaning: people mean to do various things; tools and other artifacts are meant for various things; people mean various things by using words and sentences; natural signs mean things; representations in people's minds also presumably mean things. In Varieties of Meaning, Ruth Garrett Millikan argues that these different kinds of meaning can be understood only in relation to each other.
What does meaning in the sense of purpose (when something is said to be meant for something) have to do with meaning in the sense of representing or signifying? Millikan argues that the explicit human purposes, explicit human intentions, are represented purposes. They do not merely represent purposes; they possess the purposes that they represent. She argues further that things that signify, intentional signs such as sentences, are distinguished from natural signs by having purpose essentially; therefore, unlike natural signs, intentional signs can misrepresent or be false.
Part I discusses "Purposes and Cross-Purposes"—what purposes are, the purposes of people, of their behaviors, of their body parts, of their artifacts, and of the signs they use. Part II then describes a previously unrecognized kind of natural sign, "locally recurrent" natural signs, and several varieties of intentional signs, and discusses the ways in which representations themselves are represented. Part III offers a novel interpretation of the way language is understood and of the relation between semantics and pragmatics. Part IV discusses perception and thought, exploring stages in the development of inner representations, from the simplest organisms whose behavior is governed by perception-action cycles to the perceptions and intentional attitudes of humans.
Bradford Books imprint
Russia
Authors: Gaidar Yegor 
Published: January 2019

An important Russian economist and politician takes a long view of economic history and Russia's development.
It is not so easy to take the long view of socioeconomic history when you are participating in a revolution. For that reason, Russian economist Yegor Gaidar put aside an early version of this work to take up a series of government positions—as Minister of Finance and as Boris Yeltsin's acting Prime Minister—in the early 1990s. In government, Gaidar shepherded Russia through its transition to a market economy after years of socialism. Once out of government, Gaidar turned again to his consideration of Russia's economic history and long-term economic and political challenges. This book, revised and updated shortly before his death in 2009, is the result.
Gaidar's account of long-term socioeconomic trends puts his country in historical context and outlines problems faced by Russia (and other developing economies) that more developed countries have already encountered: aging population, migration, evolution of the system of social protection, changes in the armed forces, and balancing stability and flexibility in democratic institutions.
This is not a memoir, but, Gaidar points out, neither is it “written from the position of a man who spent his entire life in a research institute.” Gaidar's “long view” is inevitably informed and enriched by his experience in government at a watershed moment in history.
Changes in bone density and bone quality caused by single fasting for 96 hours in rats
Authors: Hisatomi Yuko , Kugino Kenji 
Published: January 2019

Background
Young women occasionally engage in dietary restrictions accompanied by fasting for the purpose of losing weight, but such restrictions have various effects on body functions. The recent increase in the number of people suffering from osteoporosis has become a major social problem mainly in industrialized countries.Therefore, we think it is important to understand the effects of fasting on bone vulnerability, especially to bone quality.

Methods
Animals used male Wister rats weighing 130 g (6 weeks of age), and were divided into a control group (n = 5) and a fasting group (n = 6). The experimental period was 14 days, the control group had ad libitum food throughout the experimental period, the fasted group was fasted for 4 days, and than, had ad libitum food for 10 days. In this study, parameters related to bone fragility due to three-dimensional bone architecture were determined on Contrast enhanced micro-CT images of the lumbar spine and were used as a method for the evaluation of bone quality. In addition, a time-course observation of each individual was carried out during the fasting period and later upon resuming food intake. Cross-sectional images of all vertebrae were obtained from radiographic computed tomography and were analyzed by using Latheta software ver. 3.0 (Hitachi-Aloka Medical, Nagasaki, Japan). The region of interest that was misrecognized in each cross-sectional image was made consistent with the anatomical structure by carrying out corrections manually and by identifying the cortical bone areas and cancellous bone areas.

Results
Our findings showed that while single fasting for 96 h did not cause any major change in the macroscopic morphology of bone, it caused a marked decrease in bone density. In addition, the minimum cross-sectional moment, which indicated the “strength against bending” as well as the polar moment that indicated the “strength against torsion” were both lower than in non-fasted rats. Further, after resumption of feeding, bone mineral content in the fasting group recovered rapidly and starting at day 4 after resumption of feeding, there was no difference with the control group. On the other hand, the values of the minimum cross-sectional moment and polar moment did not recover, and the difference with the control group increased during the feeding period.

Discussion
On the basis of this study, the authors estimate that the fasting-induced decrease in bone minimum cross-sectional moment and polar moment may have been due to changes affecting some factors involved in bone quality, and thus could be useful as a parameter in future studies aimed at elucidating bone quality. At least, in the case where bone change accompanied with a change in macroscopic distribution of mineral components occurs, the values of minimum cross-sectional moment and polar moment are considered to be bone parameters that will provide valuable information to elucidate bone quality.