bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of the Smart Glucose Manager Mobile Application on Diabetes Management
Authors: Gunawardena Kasun C. , Jackson Renee , Robinett Iva , Dhaniska Lahiru , Jayamanne Shaluka , Kalpani Sumedha , Muthukuda Dimuthu 
Published: September 2018

Background: Smartphone use is rapidly growing in developing countries, providing opportunity for development of new health-based mobile applications. The present study investigated the efficacy of a newly designed mobile application, Smart Glucose Manager (SGM), in Sri Lankan patients with diabetes. Methods: A total of 67 patients with access to Android smartphones were randomized into an SGM (n = 27) and a control group (n = 25). Glycosylated hemoglobin (A1c) levels were measured at baseline and every 3 months afterward. The SGM group utilized the application daily, while control-group patients were instructed to continue their standard methods of diabetes management. Independent t-tests were utilized to assess A1c differences at 3 and 6 months postrandomization. A1c improvement, defined as A1c at 6 months minus baseline, was compared with SGM usage to assess effectiveness of diabetic management. Results: At the 6-month follow up, the SGM group had significant lower A1c levels than the control group (7.2% vs 8.17%, P < .0001). For both groups, A1c values decreased from baseline to the 3 months (SGM: 9.52% to 8.16%, P < .0001; control: 9.44% to 8.31%, P < .0001). From 3 months to 6 months, the SGM group showed further improvement of A1c (−0.96% P < .0001), whereas the control group did not ( P = 0.19). A1c improvement was positively correlated with SGM usage ( R = .81, P < .001). Conclusion: The SGM, a mobile application specifically designed to support self-management of diabetes, appeared to show long-term improvement of A1c levels in patients with diabetes residing in Sri Lanka.
On the Relationship between the Nominal Exchange Rate and Export Demand in India
Authors: Bhattacharyya Ranajoy , Rit Bipradas 
Published: September 2018

This article attempts to determine the effect of nominal exchange rates on Indian exports between 1996 and 2014. We begin by assuming that the nominal exchange rate can affect export directly as well as indirectly via its pass through on domestic prices. The analysis is conducted with quarterly data after controlling for the effect of exchange rate volatility on exports. The main results that we get are the following: There is no direct evidence that the nominal exchange rate or its volatility influences exports. However, there is a significant relationship between the relative price ratio (domestic to foreign) and export. Further, we find strong evidence of pass through of the nominal exchange rate on prices (about 54%) in the long run. We interpret this result as an evidence of the nominal exchange rate affecting exports indirectly through domestic prices. The results suggest that the debate on the influence of exchange rates on Indian export is still an open one. JEL Classification: F14, E31, G15
咏歌之不足——谈古文字中的舞蹈
Authors: 周碧香  
Published: September 2018

摘要 语言影响着思维模式, 以及人类看待世界的视角。文字是语言的纪录, 透过文字重新解读先民的思维与文化, 是当前汉字教学的着力点和文化传承的接力棒。传统儒家教育, 讲究温柔敦厚, 视 “舞” 为诗、歌之后的行动。舞蹈透由手足动作、节奏旋律表达情感, 其间敬神畏神、求雨祈福的情感, 已然不是言语、嗟叹、咏歌得以准确传达的, 故手舞之、足蹈之, 故是情感表达的极致手段。本文尝试梳理与 “舞蹈” 有关的古文字, 了解古代舞蹈的动作、物品及场域；运用文化语言学的观点, 解读其意义与文化底蕴。
ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1
Authors: Rohatgi Nidhi , Zou Wei , Collins Patrick L. , Brestoff Jonathan R. , Chen Timothy H. , Abu-Amer Yousef , Teitelbaum Steven L. 
Published: September 2018

AbstractAdditional sex comb-like 1 (ASXL1) mutations are commonly associated with myeloid malignancies and are markers of aggressive disease. The fact that ASXL1 is necessary for myeloid differentiation raises the possibility it also regulates osteoclasts. We find deletion of ASXL1 in myeloid cells results in bone loss with increased abundance of osteoclasts. Because ASXL1 is an enhancer of trithorax and polycomb (ETP) protein, we asked if it modulates osteoclast differentiation by maintaining balance between positive and negative epigenetic regulators. In fact, loss of ASXL1 induces concordant loss of inhibitory H3K27me3 with gain of H3K4me3 at key osteoclast differentiation genes, including nuclear factor for activated T cells 1 (NFATc1) and itgb3. In the setting of ASXL1 deficiency, increased NFATc1 binds to the Blimp1 (Prdm1) promoter thereby enhancing expression of this pro-osteoclastogenic gene. The global reduction of K27 trimethylation in ASXL1-deficient osteoclasts is also attended by a 40-fold increase in expression of the histone demethylase Jumonji domain-containing 3 (Jmjd3). Jmjd3 knockdown in ASXL1-deficient osteoclast precursors increases H3K27me3 on the NFATc1 promoter and impairs osteoclast formation. Thus, in addition to promoting myeloid malignancies, ASXL1 controls epigenetic reprogramming of osteoclasts to regulate bone resorption and mass.
Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia
Authors: Gaillard Coline , Surianarayanan Sangeetha , Bentley Trevor , Warr Matthew R. , Fitch Briana , Geng Huimin , Passegué Emmanuelle , de Thé Hugues , Kogan Scott C. 
Published: September 2018

AbstractAlthough the role of promyelocytic leukemia/retinoic acid receptor α (PML/RARA) fusion protein is well recognized in acute promyelocytic leukemia (APL), its contribution to initiation and maintenance of leukemogenesis is not completely understood. Transcriptome analysis in the murine MRP8-PML/RARA APL model has demonstrated modest alterations in gene expression accompanied by expansion of the promyelocyte compartment. Of particular interest, mice expressing PML/RARA showed downregulation of the transcription factor Irf8 mRNA. Interferon regulatory factor 8 (IRF8) is a known regulator of hematopoiesis. Previous research had implicated IRF8 as a tumor suppressor for myeloid neoplasia, and mice lacking IRF8 develop a well-differentiated myeloproliferative neoplasm characterized by expansion of neutrophilic lineage cells. We hypothesized that PML/RARA-mediated downregulation of Irf8 transcript levels contributes to the initiation of APL. We observed significant downregulation of IRF8 protein levels in highly purified promyelocyte populations of PML/RARA transgenic mice. We also found that loss of IRF8 results in expansion of promyelocytes in vivo, partially phenocopying the impact of PML/RARA expression. Moreover, survival experiments showed that complete loss of IRF8 leads to acceleration of APL onset in our PML/RARA mice. Collectively, these data identify IRF8 downregulation as an important factor in APL initiation and highlight a tumor-suppressor role for IRF8 in this acute leukemia.
Global Impact of Tyrosine Kinase Inhibitors on Chronic Myeloid Leukemia Epidemiology Over the Next Ten Years
Authors: Tadwalkar S. , Hughes M. 
Published: September 2018

Background: The advent of tyrosine kinase inhibitors (TKIs) has transformed the prognosis of CML. Prolonged survival has already been achieved in most patients with access to these drugs, and as access improves in more resource-constrained settings, it should be expected that this improvement will become more common, thus increasing the prevalence of CML. Aim: Through this analysis, we aim to understand the global impact of targeted therapy on CML prevalence over the next ten years. Methods: Using a critically appraised set of country-specific cancer registries, CML incidence was estimated for 45 countries, representing approximately 90% of the world population in 2018. An assumptions-based 10-year forecast model was used to incorporate the effects of improving access to TKIs in developing countries using an observed correlation between gross domestic product per capita, CML risk, and survival ( Fig 1 ). To represent the continuing optimization of TKI-based treatments, survival was further trended based on an attenuated historical trend. Prevalence was estimated as cumulative incidence over 20 years from diagnosis, with deductions for all-cause mortality. To estimate prevalent CML globally, countries were grouped into economically- and geographically-defined regions. Regional totals were projected upwards to account for the countries for whom direct estimates were not made. A control forecast was also developed where no improved survival attributed to improved access to TKIs in resource-constrained settings was assumed. The results between the two models were then compared with measure the difference attributable to the effects of improved TKI access. Results: In 2018, there will be an estimated 503,000 prevalent cases of CML globally with 267,000 of these estimated to be living in resource-constrained settings. When assuming no improvements in survival across developing countries due to TKI access, we expect this number would have been 221,000 cases. That is, 46,000 people are living with CML in resource-constrained settings now who would not be alive had it not been for access to TKIs. Conclusion: The prevalence of CML is expected to rise globally which can be primarily attributed to prolonged survival and improved access to TKIs. [Figure: see text]
Pathogenic and non-pathogenic Escherichia coli colonization and host inflammatory response in a defined microbiota mouse model
Authors: Stromberg Zachary R. , Van Goor Angelica , Redweik Graham A. J. , Wymore Brand Meghan J. , Wannemuehler Michael J. , Mellata Melha 
Published: September 2018

ABSTRACT
Most Escherichia coli strains in the human intestine are harmless. However, enterohemorrhagic E. coli (EHEC) is a foodborne pathogen that causes intestinal disease in humans. Conventionally reared (CONV) mice are inconsistent models for human infections with EHEC because they are often resistant to E. coli colonization, in part due to their gastrointestinal (GI) microbiota. Although antibiotic manipulation of the mouse microbiota has been a common means to overcome colonization resistance, these models have limitations. Currently, there are no licensed treatments for clinical EHEC infections and, thus, new tools to study EHEC colonization need to be developed. Here, we used a defined microbiota mouse model, consisting of the altered Schaedler flora (ASF), to characterize intestinal colonization and compare host responses following colonization with EHEC strain 278F2 or non-pathogenic E. coli strain MG1655. Significantly higher (P&lt;0.05) levels of both strains were found in feces and cecal and colonic contents of C3H/HeN ASF compared to C3H/HeN CONV mice. GI inflammation was significantly elevated (P&lt;0.05) in the cecum of EHEC 278F2-colonized compared to E. coli MG1655-colonized C3H/HeN ASF mice. In addition, EHEC 278F2 differentially modulated inflammatory-associated genes in colonic tissue of C3H/HeN ASF mice compared to E. coli MG1655-colonized mice. This approach allowed for prolonged colonization of the murine GI tract by pathogenic and non-pathogenic E. coli strains, and for evaluation of host inflammatory processes. Overall, this system can be used as a powerful tool for future studies to assess therapeutics, microbe-microbe interactions, and strategies for preventing EHEC infections.
Burden of cytomegalovirus reactivation post kidney transplant with antithymocyte globulin use in Thailand: A retrospective cohort study
Authors: Chitasombat Maria N. , Watcharananan Siriorn P. 
Published: September 2018

Background: Cytomegalovirus (CMV) is an important cause of infectious complications after kidney transplantation (KT), especially among patients receiving antithymocyte globulin (ATG). CMV infection can result in organ dysfunction and indirect effects such as graft rejection, graft failure, and opportunistic infections. Prevention of CMV reactivation includes pre-emptive or prophylactic approaches. Access to valganciclovir prophylaxis is limited by high cost. Our objective is to determine the burden and cost of treatment for CMV reactivation/disease among KT recipients who received ATG in Thailand since its first use in our center. Methods: We conducted a single-center retrospective cohort study of KT patients who received ATG during 2010-2013. We reviewed patients’ characteristics, type of CMV prophylaxis, incidence of CMV reactivation, and outcome (co-infections, graft function and death). We compared the treatment cost between patients with and without CMV reactivation. Results: Thirty patients included in the study had CMV serostatus D+/R+. Twenty-nine patients received intravenous ganciclovir early after KT as inpatients. Only three received outpatient valganciclovir prophylaxis. Incidence of CMV reactivation was 43%, with a median onset of 91 (range 23-1007) days after KT. Three patients had CMV end-organ disease; enterocolitis or retinitis. Infectious complication rate among ATG-treated KT patients was up to 83%, with a trend toward a higher rate among those with CMV reactivation (P = 0.087). Patients with CMV reactivation/disease required longer duration of hospitalization (P = 0.018). The rate of graft loss was 17%. The survival rate was 97%. The cost of treatment among patients with CMV reactivation was significantly higher for both inpatient setting (P = 0.021) and total cost (P = 0.035) than in those without CMV reactivation. Conclusions: Burden of infectious complications among ATG-treated KT patients was high. CMV reactivation is common and associated with longer duration of hospitalization and higher cost.
Initiative prioritization for innovation in the Brazilian pharmaceutical industry: a proposal using multicriteria
Authors: Cruz Eduardo Picanço , Antunes Adelaide Maria De Souza , Borschiver Suzana 
Published: September 2018

The structure of the pharmaceutical industry requires special attention on the part of developing countries, whose populations remain dependent both on the distribution of drugs and on a policy of significant reduction in established prices. It is essential that governments, businesses and universities work together in order to plan future strategies for this sector. This article reflects on the Forum’s technological innovation initiatives, financed with more than R$200 million in resources from Sectoral Funds. Given this industry’s dependence on innovation, the present work presents a decision-making methodology for determining investment priorities to be applied by the working group of the above-mentioned Forum. It also aims to offer support mechanisms for a better distribution of financial resources by creating a hierarchy of the already functioning programs of the government agencies.
A importância da estratégia organizacional para a Confederação Brasileira de Voleibol
Authors: Souza Sávio Lourenço 
Published: September 2018

O objetivo geral deste trabalho é analisar a estratégia organizacional desenvolvida por uma organização brasileira de administração esportiva, a Confederação Brasileira de Voleibol (CBV) nos últimos 30 anos, a partir da metodologia das “5 forças de Porter”. Ficou estabelecido a análise da Confederação Brasileira de Voleibol como estudo de caso. Ao abordarmos o case da CBV foi possível detectar os ganhos que uma instituição de administração esportiva pôde obter a partir da definição de uma estratégia organizacional e, na seqüência, do desenvolvimento de um planejamento estratégico estruturado. Planejamento este que teve início há 30 anos baseado em uma estratégia inovadora que tinha como alicerce o entendimento do esporte como um negócio. Entretanto, os resultados alcançados não estão condicionados apenas ao fato de possuir um plano estratégico, tão importante quanto ter é saber executá-lo.
APOIO GERENCIAL NA INCUBAÇÃO DE EMPRESAS DE BASE TECNOLÓGICA: O CASO DA INCUBADORA CISE
Authors: Costa Larissa Florêncio Silva da , França Mariana Carla Lima , Teixeira Rivanda Meira 
Published: September 2018

O presente estudo tem como objetivo geral analisar o apoio gerencial oferecido pela incubadora CISE aos empreendimentos de base tecnológica em fase de incubação. Adotou-se a estratégia de pesquisa de estudo de caso único e as evidências foram coletadas através de entrevistas e de fontes documentais. Com base nas evidências encontradas observou-se que a incubadora CISE considera que vem cumprindo seu papel de apoiadora no desenvolvimento gerencial dos seus empreendimentos incubados, no que concerne à estrutura física, assessoria/consultoria e treinamento. No entanto, foram constatadas diferentes percepções por parte dos incubados. Para eles a incubadora vem atendendo parcialmente suas necessidades, especialmente com relação a falta de consultoria/assessoria. Para as estas empresas o apoio na gestão de seus negócios permitiria que o projeto inicial de ingresso fosse desenvolvido e aprimorado e assim seria possível enfocar o aspecto estratégico do negócio e não o operacional.
RESPONSABILIDADE SOCIAL: A PARTICIPAÇÃO DAS MULHERES NAS ORGANIZAÇÕES DE BLUMENAU (SC)
Authors: Dreher Marialva Tomio , Dal Moro Renata 
Published: September 2018

Este estudo objetiva analisar a participação das mulheres na gestão da responsabilidade social (RS) das Organizações de Blumenau (SC). O método de pesquisa foi à qualitativa e as técnicas exploratórias e descritivas. A população foi de 21 gestoras de RS das organizações vinculadas ao Núcleo de Responsabilidade Social da Associação Comercial e Industrial de Blumenau (NÚCLEO RS/ACIB). Os resultados confirmam que o índice de 21 mulheres gestoras de RS é elevado considerando que há 24 organizações no Núcleo. O perfil demonstra que a maioria é casada e possui filhos, estes motivos não limitam as gestoras a ingressar no mercado de trabalho e a assumir uma gestão de RS, pelo contrário representa uma conquista profissional. Todavia, afirmam que devido ao acúmulo de atividades, doméstica e profissional, ocorrem exigências demasiadas pelo excesso de compromissos. Quanto à gestão da RS, observou-se que há uma identificação pessoal das gestoras com a temática.
DIFERENÇAS DE PERCEPÇÃO DE ADOTANTES E NÃO-ADOTANTES QUANTO AO USO DE SERVIÇOS DE MOBILE BANKING E SUA RELAÇÃO COM AS CARACTERÍSTICAS INDIVIDUAIS DE INOVATIVIDADE
Authors: Martins Ramos Anatalia Saraiva , Pimenta Iris Linhares , Barbosa Rodrigues Paula Agusta 
Published: September 2018

O presente trabalho buscou analisar as percepções dos consumidores quanto à adoção de novas tecnologias de serviços bancários baseados na mobilidade - o Mobile Banking. Tendo como base a clássica Teoria de Difusão de Inovações (TDI) proposta por Rogers (1995), foi empreendida uma investigação quantitativa do tipo exploratória com 96 adotantes ou potenciais adotantes do mobile banking escolhidos de forma não-probabilística por conveniência. A análise estatística ocorreu em três etapas: análise descritiva, teste de variância e correlação. Constatou-se que os não adotantes têm uma visão mais negativa dos atributos da inovação (vantagem relativa, observabilidade, compatibilidade e complexibilidade). Confirmou-se que as características típicas de inovatividade influenciam a percepção acerca dos serviços de Mobile Banking na maior parte das variáveis. O artigo finaliza com as implicações teóricas e gerenciais decorrentes dos resultados.
Receiving antenna electrodynamic model in terms of waveguide representation of HF field
Authors: Хахинов Виталий , Khakhinov Vitaliy 
Published: September 2018

The receiving antenna is an important part of a radio channel that requires electrodynamic approach in mathematical simulation of its characteristics. Since the invention of radio, and due to further theoretical studies of radio signal transmission, the following situation has arisen: researchers’ attention to receiving antennas is inversely proportional to the factor by which their number exceeds the number of transmitting antennas. We address the problem of building a receiving antenna electrodynamic model in terms of a waveguide representation of HF field. Structurally, the antenna is considered as metal wires of a finite length and arbitrary configuration. Current distribution in antenna is calculated using the long-line theory and normal-mode approach. The mathematical representation of the receiving antenna electrodynamic model is calculation expressions for receiving coefficients of normal modes. They reflect the effects of receiving antenna characteristics, including its directional pattern, on effectiveness of the incident HF field energy conversion into the energy of the driven current waves and final distribution of net current in antenna. These expressions are used to derive the expression to calculate the effective length of the receiving antenna.
The obtained mathematical expressions of the receiving antenna electrodynamic model do not contradict the principle of antenna reciprocity.
We present calculation formulas for the receiving coefficients and excitation of the isotropic antenna electromagnetic model.
The Secret Self: ‘Literary’ women-only short story anthologies and the modernist paradigm
Authors: Tura Vecino Aleix 
Published: September 2018

Abstract
Identity-themed short story anthologies are a technology that has been particularly impactful in the development and transmission of short stories since the 1980s. By associating the short form to critical discourses of identity formation, these often overlooked publications have been, and continue to be, key in granting commercial success and academic consideration to the genre. One of the most fruitful relationships these anthologies have exploited is the one between short stories and female identity, grounded on a theoretical tradition connecting ‘minor’ forms with women writers. This article explores how a certain kind of gender-themed short story anthologies perform this association. Through focus on the exemplary case of Hermione Lee’s three-volume anthology The Secret Self, it argues that so-called ‘literary’ or ‘general’ anthologies typically establish a connection between the notion of ‘woman’ and the short form through the undeclared lens of modernism. Realizing this, it proposes and opens up a space for re-evaluating the cultural role that these texts play in our society.
‘We are cyborgs’: Technology in Hari Kunzru’s short fiction
Authors: Jansen Bettina 
Published: September 2018

Abstract
This article argues that a concern with technology and the social transformations initiated by the cyborgization of contemporary life permeates the semantics and aesthetics of several short stories by Hari Kunzru. Not only do the ‘cyborg stories’ address the increasingly tangled interface between human being and machine as a subject matter, but they also use the flexibility of the short story form to explore the ways in which technology, social media and the Digital Revolution alter human communication and modes of narration. By analyzing Kunzru’s stories through the lens of Donna Haraway’s cyborg theory and deconstructive philosophies of community, I will show that these short stories are ultimately concerned with the construction of community or, as Haraway says, ‘relationality’ in the Cyborg Age.
Intertextuality and intermediality in Janice Galloway’s ‘Scenes from the Life’ (Blood 1991)
Authors: Sacido-Romero Jorge 
Published: September 2018

Abstract
Janice Galloway’s ‘Scenes from the Life’ are a set of five pieces collected in Blood (1991), her first book of stories. As in the case of the rest of her production, these stories are highly experimental texts that convey the author’s criticism of dominant patriarchal ideology by rehearsing different combinations of narrative, intertextual and intermedial elements, which entail different modalities of intratextual witnesses of the action and potential surrogates of the reader. Resorting to Irina O. Rajewsky’s concepts of ‘intertextual reference’ and ‘intermedial reference’ as analytical tools, this article reorders the otherwise random appearance and numbering of the five pieces by establishing a logical line of progression derived from the different proportions of intertextual and intermedial referencing that each of the text contains. Though they remain stories, ‘Scenes from the Life’ are good examples of the author’s poetics of liminality, which, according to recent commentators, the short story comes closer to than any other literary genre.