bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between METS-IR Index and Obstructive Sleep Apnea-Hypopnea Syndrome: A Cross-Sectional Study Based on the National Health and Nutrition Examination Survey from 2015 to 2018
Authors: Hou Yisen , Li Rui , Xu Zhen , Chen Wenhao , Li Zhiwen , Jiang Weirong , Meng Yong , Han Jianli 
Published: November 2024

Abstract

Background
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder closely associated with metabolic syndrome. The metabolic score for insulin resistance (METS-IR) is a new indicator used to assess insulin resistance. However, evidence on the association between METS-IR and OSAHS remains limited.
Objective
This study aimed to analyze the association between METS-IR and OSAHS in American adults.
Methods
This study utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2018. We analyzed METS-IR and the prevalence of OSAHS in adult participants. Individuals aged 20 years and older were included, while those without available BMI, fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) data were excluded. Logistic regression analysis, subgroup analysis, and restricted cubic spline analysis were employed to evaluate the association between METS-IR and OSAHS, adjusting for potential confounders including sex, age, race/ethnicity, education level, income, smoking status, alcohol consumption, diabetes status, and lipid levels.
Results:
A total of 4274 adult participants were included in the study. Participants were categorized into quartiles based on METS-IR levels, with ranges of 19.98–33.94, 33.94–41.60, 41.60-51.15, and 51.15-124.47, respectively. After adjusting for age, sex, race/ethnicity, education level, smoking status, alcohol consumption status, hypertension status, diabetes status, and dyslipidemia status, METS-IR was positively associated with the risk of OSAHS (OR = 1.05, 95% CI: 1.03, 1.07). Specifically, each one-unit increase in METS-IR was associated with a 5% increase in the risk of OSAHS. Subgroup analysis revealed a significant positive correlation between METS-IR and the incidence of OSAHS in the highest METS-IR quartile. This association was particularly pronounced among Mexican Americans (OR = 6.33, 95% CI: 2.13, 23.67) and non-Hispanic Black individuals (OR = 12.22, 95% CI: 5.89, 26.62). Additionally, after controlling for potential confounders, the association between METS-IR and OSAHS remained significant. Notably, individuals with diabetes, hypertension, and hypertriglyceridemia were at a greater risk of OSAHS.
Conclusion:
The results of this study demonstrated a significant positive association between METS-IR and the incidence of OSAHS, which persisted after adjusting for various confounders. This suggests that METS-IR may be a potential risk factor for OSAHS. In clinical practice, the management of metabolic syndrome should be emphasized to prevent the occurrence of OSAHS.
Evaluation of two low-level laser techniques as an adjunct to basic periodontal therapy: a randomized clinical trial
Authors: Silva Régia Carla Medeiros da , Silva Lucas Gabriel Cunha da , Cruz Natália Teixeira Silva , Barbosa Adylla Rominne Lima , Maia Paulo Raphael Leite , Martins Ana Rafaela Luz de Aquino 
Published: November 2024

Abstract

Aim: To assess and compare two techniques of low-level laser application—transgingival (TLLLT) and intrasulcular (ILLLT)—used in photobiomodulation as an adjunct to basic periodontal therapy (BPT) in patients with periodontitis.
Methods: A randomized, split-mouth, double-blind clinical trial was conducted, selecting three diseased periodontal sites from different quadrants in each patient. These sites were assigned to one of three treatment groups: SRP (control), SRP + TLLLT (test 1), and SRP + ILLLT (test 2). Low-level laser therapy in the test groups was applied at 48 hours, 7 days, and 14 days after full-mouth SRP. Clinical parameters such as probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were assessed at baseline (T0), 3 months (T1), and 6 months (T2). Standardized periapical radiographs were used to assess radiographic bone density (RBD) 6 months post-treatment. Statistical analyses included repeated measures ANOVA for continuous variables and chi-square tests for categorical variables, with significance set at p < 0.05 and a 95% confidence interval.
Results: Significant reductions in PD (p < 0.001) and CAL (p < 0.001) were observed across all groups at 3 and 6 months, with no significant differences between groups. There were also no significant changes in BOP and RBD between groups at the follow-up intervals.
Conclusion: Adjunctive photobiomodulation did not provide additional clinical or radiographic benefits over SRP alone, regardless of the laser application technique employed.
NET-related genes predict prognosis and are correlated with the immune microenvironment in osteosarcoma
Authors: Chu Dawei , Huang Rui , Shi Jian dang , Xu Ruiqing , Wei Daihao 
Published: November 2024

Abstract

Background
Osteosarcoma is the most common primary bone tumor. It has a high rate of early metastasis, and its treatment is one of the most challenging topics in the bone tumor field. Recent studies have shown that neutrophil extracellular traps play an important role in tumor metastasis and may provide new horizons for exploring metastasis in osteosarcoma.
Methods
OS data were downloaded from the TARGET database and Gene Expression Omnibus datasets. Univariate Cox regression was conducted to assess NETRGs. Patients were subsequently categorized into high- and low-risk groups on the basis of risk score values derived from multivariate Cox analysis, and prognostic models were established. The immune infiltration of relevant genes and drug sensitivity of key genes were also analyzed.
Results
A total of 15 NET-related genes associated with osteosarcoma metastases were identified. Among them, a total of 4 genes were related to prognosis, namely, MAPK1, CFH, ATG7 and DDIT4, and a prognostic model based on these 4 genes was established. The prognosis was worse in the high-risk group, whose areas under the ROC curves (AUCs) were 0.857, 0.779, and 0.689 at 1, 3, and 5 years, respectively. The key genes were subsequently found to be associated with the infiltration of 20 types of immune cells. Finally, the small-molecule drug toxin c 10, an approximately 6700 mw protein, may target key genes. Finally, ATG7 was validated at the histological level by combining the results of the validation group dataset analysis.
Conclusions
A risk model based on 4 NETRDEGs is a reliable prognostic predictor for OS patients, and ATG7 may serve as a new diagnostic and therapeutic target.
Effects of Different Physical Activity Interventions on Symptoms of Anxiety and Depression in Children and Adolescents ：A Network Meta-Analysis of Randomized Controlled Trials
Authors: Zhang Zhaoxu , Li Lan , Dong Kuan , Li Dong , Guo Ke-Lei 
Published: November 2024

Abstract

Background: Anxiety and depression are widespread mental health conditions worldwide, with significant negative impacts on patients. These conditions are especially prevalent among adolescents. Recently, exercise therapy has gained popularity as a supplementary approach to managing anxiety and depression. Numerous studies have started investigating the relationship between physical activity and anxiety and depressive symptoms in adolescents. Nonetheless, systematic evidence to guide the optimal choice of physical activities remains insufficient. This study aims to compare and rank various physical activity interventions to determine the most effective ones for treating adolescent anxiety and depression, ultimately providing valuable insights for clinical practice.
Methods: A thorough search was performed in PubMed, Embase, Web of Science, and the Cochrane Library to identify randomized controlled trials evaluating the impact of physical activity interventions on children with anxiety and depression. The search encompassed all available records from the inception of each database up to April 2024. Literature screening, data extraction, and quality evaluation were managed independently by two reviewers. Subsequently, Stata version 15.1 was employed to conduct a network meta-analysis.
Results: A total of 25 studies were included in the analysis. The findings demonstrate that High-intensity interval training is the most effective intervention for preventing and reducing depression and anxiety in children(SUCRA = 85.4%), followed by REC (SUCRA = 82.2%). Additionally, Mind-body exercise and Moderate-to-vigorous exercise were identified as relatively effective strategies, with SUCRA scores of 70.9% and 67.1%, respectively.
Conclusions: Our study shows that High-intensity interval training and Resistance training are the most effective interventions overall. Selecting the optimal exercise type should be individualized based on each child’s unique needs while encouraging consistent participation in physical activity.
PROSPERO: CRD42024563543 DATE: July 10, 2024 retrospectively registered
Prevalence, incidence and impact of cancer in atrial fibrillation: a systematic review and meta-analysis of 6,600,000 patients
Authors: Mao Shaobin , Wang Leigang , Fan Hongxuan , Yang Ling , Yang Zhuoxuan , Zhang Wenjing , Wang Miao , Hao Liuyi , Liang Bin 
Published: November 2024

Abstract

Aims
Contemporary studies have indicated that atrial fibrillation (AF) is common among cancer patients, and affects the prognosis of cancer patients. The other hand, AF and cancer share the same risk factors, while the prevalence, incidence and impact of cancer in AF patients is unclear. Our aim was to estimate the prevalence and incidence of cancer, and focus on the impact of cancer on clinical outcome.
Methods and Results
We searched the PubMed, Web of science, Embase and Cochrane Library databases, and conducted according to international guidelines to perform a system review and meta-analysis. All studies reporting the prevalence and incidence of cancer were included. We extracted the data from these studies and used the random effect model to pool the result. The prevalence and incidence of cancer overall were 1153.31 (95%CI: 959.19-1380.72) per 10000 patients, 173.28 (95%CI: 131.89-227.66) per 10000 person-years, respectively. Otherwise, cancer prevalence and incidence had been shown to vary by cancer type, the incidence also varies gender and comorbidities. And cancer is associated with higher risk of all-death (OR: 1.78, 95%CI: 1.51–2.08) and bleeding (OR: 1.44, 95%CI: 1.26–1.65), no significant differences in cardiovascular death and stroke/system embolism.
Conclusions
Cancer is common in AF patients, affecting 11% of patients. The incidence of cancer cannot be ignored. Cancer is associated with the worse outcome in AF patients, with more than 1.7-flod higher risk of all-death and increased the risk of bleeding.
Use of CRISP modifiers for adults undergoing cardiac catheterization procedures: A single center experience
Authors: Reynolds Kathryn P , Mejia Ernesto , Soszyn Natalie , Morgan Gareth , Zablah Jenny E. 
Published: November 2024

Abstract

Background The Catheterization RISk Score for Pediatrics (CRISP) has been validated and widely adopted as a model to predict adverse outcomes. We sought to determine if the addition of three modifiers (NYHA Class > 2, prior sternotomies > 2, and BMI > 30) to the CRISP score would better predict adverse events (AE) in adults undergoing cardiac catheterization at our institution.Methods All adults (> 18 years) who underwent cardiac catheterization at the Children’s Hospital Colorado from November 2016 to November 2021 were included. Baseline and modified CRISP scores with adult modifiers and AEs were analyzed.Results Of a total of 401 cases, there were 27 AEs (6.7%). A higher CRISP score was associated with an increased risk of AEs (p = 0.004). A ROC analysis of the CRISP score gave a AUC of 66% with a cut-off point of 5.5 giving a sensitivity of 74% and specificity of 52%. The modifiers individually did not significantly correlate with AEs. Higher modified CRISP score was similarly associated with an increased risk of AEs (p = 0.01). ROC analysis for the modified CRISP score gave an AUC of 64%. A cut-off point of 6.5 gave the best result with a sensitivity of 59% and specificity of 61%.Conclusion A modified CRISP score which included adult modifiers similarly predicts AEs in adults with congenital heart disease. These adult modifiers are easy to incorporate into the CRISP score. The CRISP score also predicted AEs in adults with congenital heart disease.
Differential prognostic significance of tumor size and lymph node in invasive lobular carcinoma of breast
Authors: Kang Eunhye , Shin Ik Beom , Jung Ji-Jung , Byeon Jinyoung , Choi Yunhee , Cheun Jong-Ho , Lee Han-Byoel , Han Wonshik , Kim Hong-Kyu , Moon Hyeong-Gon 
Published: November 2024

Abstract

Despite invasive lobular carcinoma (ILC) having distinct clinical and pathological characteristics, it shares the same prognostication system and adjuvant treatment strategies with invasive ductal carcinoma (IDC). We analyzed data from 16,410 IDC and ILC patients treated at Seoul National University Hospital (2005–2022), along with 247,290 cases from the Surveillance, Epidemiology, and End Results (SEER) database (2010–2015). ILC patients were characterized by older age at diagnosis, larger tumors, and predominantly HR-positive/HER2-negative status. ILC showed unique prognostic implications, particularly in anatomic features. Unlike IDC, tumor size and nodal status had differential prognostic impact on survival in ILC. While T stages showed no significant survival difference in ILC patients, nodal involvement had a more pronounced prognostic impact in both SNUH and SEER datasets. These findings suggest that in ILC, tumor size may not be as strong a survival predictor as in IDC, while advanced nodal involvement indicates higher breast cancer-specific mortality risk.
Factors Associated with the Pricing and Reimbursement System of Orphan Drugs in South Korea
Authors: Lee Se Hee , Lee Sung Kyung , Bang Joon Seok , Lee Jong Hyuk 
Published: November 2024

Abstract

Background Orphan drug pricing in South Korea, including its workings and determinants, is a complicated aspect of the country’s health care system. Therefore, this study identified the factors associated with the pricing and reimbursement system of orphan drugs in South Korea.Methods The study screened a total of 66 orphan drugs out of the whole set of newly reimbursed drugs from 2012 to 2022. The analyses presented the characteristics of the orphan drugs and accounted for correlations between treatment cost and other seemingly related variables. Formal multivariate regression analyses pointed out associated factors in multivariate settings.Results Annual treatment cost per patient displayed a weakly negative correlation with the number of patients. Meanwhile, treatment cost exhibited a strongly positive correlation with the average of adjusted prices in seven advanced countries, reaching an adjusted R-squared value of 0.99. Treatment cost also showed a positive correlation with budget impact.Conclusions The pricing of orphan drugs in South Korea is predominantly influenced by external reference pricing. Drugs targeting smaller patient populations tend to be priced higher. Thus, the study highlights the interplay between drug pricing and external reference prices, drug characteristics, and pricing and reimbursement pathways. The findings can guide policymakers, pharmaceutical companies, and health care providers in their efforts to balance patient accessibility with orphan drug development and the financial sustainability of public health insurance.
A Comparative Study of X-ray and 3D CT in the Evaluation of Pauwels Classification for Femoral Neck Fractures
Authors: Sun Ming , Liang Hairui , Bai Tong , Zhang Tianyu , Xu Rongda , Duan siyu , Cai Zhencun 
Published: November 2024

Abstract

Background
To compare the accuracy of X-ray and 3D CT in measuring the Pauwels angle of femoral neck fractures and the reliability of these methods in guiding Pauwels classification.
Methods
X-ray and CT images of 40 femoral neck fracture patients from our hospital were collected. Three physicians measured the Pauwels angle on both X-ray and CT images using the PACS Workstation system, performing the measurements twice and classifying the fractures based on the Pauwels classification. Consistency and reproducibility analyses were conducted to evaluate the performance of the two methods.
Results
The Pauwels angles and classification results obtained by the chief physician, attending physician, and resident physician using both X-ray and CT methods showed statistically significant differences, with P values all < 0.05. For the consistency analysis, the interclass correlation coefficients (ICC) for two measurements were: for the X-ray method, ICCs of 0.712, 0.882, and 0.578 for 1vs2, 1vs3, and 2vs3, respectively, and ICCs of 0.357, 0.631, and 0.596 for the same pairs; for the CT method, ICCs of 0.935, 0.966, and 0.960 for 1vs2, 1vs3, and 2vs3, and ICCs of 0.896, 0.952, and 0.872 for the same pairs. The reproducibility analysis for the three physicians showed that the ICCs for the X-ray method were 0.767, 0.720, and 0.754, while for the CT method, the ICCs were 0.945, 0.918, and 0.964. The CT method demonstrated superior consistency and reproducibility compared to the X-ray method.
Conclusions
Compared to X-rays, 3D CT scanning is more accurate in measuring the Pauwels angle of femoral neck fractures and provides more reliable guidance for Pauwels classification, with higher clinical reproducibility. Therefore, it is recommended to use CT scanning instead of X-ray for preoperative evaluation of fracture stability in femoral neck fracture patients.
Comparative analysis of the efficacy and safety of complete da Vinci robot versus laparoscopy in total gastrectomy and delayed detached gastric modified Overlap esophagojejunostomy for gastric cancer: a retrospective cohort study
Authors: Huang Xiaodong , Li Weidong , Han Xiaowen , Zhang Jiayi , Chen Hao 
Published: November 2024

Abstract

Objective：To investigate the feasibility and safety of fluorescence laparoscopic intraoperative positioning combined with complete da Vinci robotic total gastrectomy for gastric cancer and delayed detachment of the stomach in modified Overlap oesophagojejunostomy.
Methods：The clinical data of 22 gastric cancer patients treated with fluorescent laparoscopic intraoperative localization combined with complete da Vinci robotic total gastrectomy or fluorescent laparoscopic total gastrectomy at the Department of Oncology, the Second Hospital of Lanzhou University, were retrospectively analyzed and relevant literature was searched and reviewed.
Results：The clinical data of 22 patients were included for analysis, including 11 in the laparoscopic group and 11 in the robotic group. All surgeries were successfully completed. In terms of baseline data, there was no statistically significant difference between the two groups. Robotic group was higher than laparoscopic group in terms of operative time and hospitalisation costs (P<0.05); the neutrophil ratio on the third postoperative day was lower in the robotic group than in the laparoscopic group (P <0.05); the comparison between the first five cases and the last six cases in the robotic group showed that the intraoperative blood loss in the last six cases was lower than that in the first five cases (P<0.05).
Conclusions：Intraoperative localization with fluorescence laparoscopy combined with total robotic gastrectomy for gastric cancer and modified Overlap esophagojejunostomy with delayed gastric transection has equivalent efficacy to fluorescence laparoscopy total gastrectomy, and is safe and feasible. With the increase of surgical proficiency, intraoperative blood loss can be better controlled, which is worthy of clinical promotion and application.
Comparative analysis of 3D-culture techniques for multicellular colorectal tumour spheroids and development of a novel SW48 3D model
Authors: Mateos-Sánchez Carlos , González Beatriz , de Miguel-García Gisela , Marcote-Corral Iris , Alonso Sergio 
Published: November 2024

Abstract

Background
Colorectal cancer (CRC) remains a significant global health challenge, with nearly 2 million diagnosed cases and over 900,000 deaths annually despite therapeutic advancements. The high morbidity and mortality rates underscore the need for more efficient therapies. Three-dimensional (3D) cell culture models have emerged as more physiologically relevant alternatives to traditional two-dimensional (2D) models for drug screening and mechanistic studies. However, generating consistent spheroids across different CRC cell lines presents technical challenges, and protocols remain inconsistent.
Methods
This study evaluated different 3D culture methodologies, i.e. overlay on agarose, hanging drop, and U-bottom plates without matrix or with methylcellulose, Matrigel or collagen type I hydrogels, across eight CRC cell lines. Tumorsphere morphology and cell viability were analysed. Co-cultures with immortalised colonic fibroblasts were explored to improve the physiological relevance of the tumour models.
Results
The study provided insights into the morphological and viability characteristics of 3D cultures across multiple CRC cell lines. A novel compact spheroid model using the SW48 cell line was successfully developed. Co-culture experiments with fibroblasts offered additional insights into tumour-stroma interactions in a 3D setting.
Conclusions
This study contributes to the advancement of more physiologically relevant in vitro CRC models, potentially enhancing the accuracy of preclinical studies and drug screening processes. The successful 3D model of SW48 expands the repertoire of CRC cell lines available for 3D culture studies. These findings may lead to improved preclinical models for CRC research and drug development.