bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, 2D-QSAR Studies and Biological Evaluation of Quinazoline Derivatives as Potent Anti-Trypanosoma cruzi Agents
Authors: Bollini Mariela , Bruno Ana M. , Niño María E. , Casal Juan J. , Sasiambarrena Leandro D. , Valdez Damián A.G. , Battini Leandro , Puente Vanesa R. , Lombardo María E. 
Published: October 2018

Background:
Chagas disease affects about 7 million people worldwide. Only two drugs
are currently available for the treatment for this parasite disease, namely, benznidazol (Bzn) and
nifurtimox (Nfx). Both drugs have limited curative power in the chronic phase of the disease.
Therefore, continuous research is an urgent need so as to discover novel therapeutic alternatives.

Objective:
The development of safer and more efficient therapeutic anti-T. cruzi drugs continues to
be a major goal in trypanocidal chemotherapy.

Method:
Synthesis, 2D-QSAR and drug-like physicochemical properties of a set of quinazolinone
and quinazoline derivatives were studied as trypanocidal agents. All compounds were screened in
vitro against Trypanosoma cruzi (Tulahuen strain, Tul 2 stock) epimastigotes and bloodstream trypomastigotes.

Results:
Out of 34 compounds synthesized and tested, six compounds (5a, 5b, 9b, 9h, 13f and
13p) displayed significant activity against both epimastigotes and tripomastigotes, without exerting
toxicity on Vero cells.

Conclusion:
The antiprotozoal activity of these quinazolinone and quinazoline derivatives represents
an interesting starting point for a medicinal chemistry program aiming at the development of
novel chemotherapies for Chagas disease.
Impact of Grinding Procedure on the Yield and Quality of the Extract from Clove Buds Using Supercritical Fluid Extraction
Authors: Johner Julio C.F. , Hatami Tahmasb , Carvalho Pedro I. N. , Meireles M. Angela A. 
Published: October 2018

Introduction:
The effects of the grinding procedure on the supercritical fluid extraction (SFE) yields of eugenol, β-caryophyllene, α-humulene, and eugenyl acetate from clove are discussed in detail in this paper.

Methods:
For this purpose, five grinding procedures were employed: 1) continuous 1-min grinding, 2) continuous 2-min grinding, 3) two 1-min grinding periods with 6-min stop in between 4) continuous 4-min grinding, and 5) four 1-min grinding periods with 6-min stops in between. After that, the extractor was filled with 12 g of milled clove obtained using one of the grinding procedures while the other SFE parameters were kept constant (pressure of 150 bar, temperature of 40 °C, supercritical CO2 flow rate of 1.03×10−4 kg/s, static time of 20 min, and dynamic extraction time of 15 min). Then, the composition of the extract was evaluated by gas chromatography (GC).

Conclusion:
It was found that the grinding procedure has considerable effects on the recoveries of eugenol, β-caryophyllene, α-humulene, and eugenyl acetate from clove, and employing four 1-min grinding periods with 6-min stops in between as the grinding procedure gave the highest content of the aforementioned components in the extract.
Socio-Behavioral Risk Factors Associated with Cryptosporidiosis in HIV/AIDS Patients Visiting the HIV Referral Clinic at Cape Coast Teaching Hospital, Ghana
Authors: Opoku Yeboah K. , Boampong Johnson N. , Ayi Irene , Kwakye-Nuako Godwin , Obiri-Yeboah Dorcas , Koranteng Harriet , Ghartey-Kwansah George , Asare Kwame K. 
Published: October 2018

Objective:To identify the socio-behavioral risk factors associated with cryptosporidiosis among HIV/AIDS patients with chronic diarrhea symptoms visiting the HIV referral clinic at Cape Coast Teaching Hospital, Ghana.Methods:A cross-sectional study was conducted among 50 HIV/AIDS patients with recurrent diarrhea. Questionnaires were administered to collect social and behavioral risk factors associated withCryptosporidiumand other opportunistic protozoan parasitic infections in HIV patients. Stool samples were collected for the diagnosis of enteric protozoan pathogens using modified Ziehl-Neelsen and acid-fast staining methods. CD4+cells counts of study subjects were obtained from patients clinical records. The data obtained were analyzed using Pearson chi-square and multivariate-adjusted statistics tool on SPSS 16 for Windows.Results:Twenty-seven (54%) of the subjects were infected with enteric protozoan pathogens. The prevalences ofCryptosporidium,CyclosporaandMicrosporidiuminfections were 46%, 32% and 16%, respectively.Cryptosporidiuminfection was significantly associated with drinking water (×2=13.528, p<0.001),Cyclosporawas associated with the type of drinking water (×2=14.931, p<0.001) and toilet facilities used by the study subjects (×2=12.463, p<0.01), whilesMicrosporidiuminfection was associated with hand washing behavior (×2=12.463, p<0.01). Enteric protozoans were frequently encountered among subjects with CD4+ T-cell count <200 cells/mm3. However, coinfection ofCyclospora spp&Cryptosporidiumspp was not observed in CD4+cell count <200 and >500 cells/mm3.Multivariate analysis showed that the risk factor forCryptosporidiuminfection among HIV/AIDS patients was the source of drinking water (pipe borne water 76.2% prevalence: sachet water 25%; OR=0.10, 95%CI: 0.03-0.39, p<0.001).Conclusion:We report the risk factor for exposure ofCryptosporidiuminfection among HIV/AIDS patients for the first time in Ghana. The contamination of drinking water by protozoan parasites should be a public health concern. These results provide the stepping block to understand the transmission dynamics ofCryptosporidiumand other opportunistic pathogens in HIV/AIDS infected patients in Ghana.
Hemangioma hepático congénito gigante: síndrome de Kasabach-Merrit
Authors: Cortes Caballero Carlos , Vera Campos Silvia Nathalia , Mogollon Zehr Margarita Rosa 
Published: October 2018

Los hemangiomas son las proliferaciones más frecuentes en la edad pediátrica, y el hepático es de los más comunes entre los viscerales, su importancia radica en el diagnostico precoz para enfocar el tratamiento. Se presenta el caso de un neonato con compromiso ventilatorio secundario al efecto de una masa gigante que ecográficamente correspondió a hemangioma hepático, se realizó resección quirúrgica y posteriormente fue enviada a patología que confirmó el diagnostico.
EVALUASI NILAI CACAT DAN CITA RASA KOPI ROBUSTA (Coffea canephora L.) YANG DIPRODUKSI IKM KOPI DI KABUPATEN TANGGAMUS [Evaluation of Defect Value and Flavour Robusta Coffee (Coffea canephora L.) Produced by Small and Medium Industri Sector of Coffee in Tanggamus District]
Authors: Setyani Sri , Subeki Subeki , Grace Henrica Agustina 
Published: October 2018

The purpose of this study was to evaluate the defects, moisture content, flavor, and overall acceptance of Robusta coffee from 20 coffee producers in Tanggamus Regency. Taste testing involved some expert panelists. The data were analyzed descriptively. The results showed that as much as 70% of coffee quality was following SNI 01-2907-2008. The defect value of coffee was at the quality level of 5 until the inferior original quality (“kopi asalan”). The main percentages of the defects were broken seeds, brown beans, black seeds and then followed by hollow seeds. The water content of the coffee was varied between 5.07-7.27. The taste of coffee was dominated by green/grassy, the average taste was slightly bitter, the colors ranged from brown, black and cinnamon-like color, while, the overall acceptance was somewhat like. This results indicated that standard operating procedure is required to be implemented by coffee producers (IKM) in Tanggamus Regency to improve the quality of the coffee.
PERUBAHAN SIFAT FISIKOKIMIA PISANG AMBON CURUP (Musa sapientum cv. ‘Ambon Curup’) SELAMA PENYIMPANAN MENGGUNAKAN Ca(OH)2 - SILIKA GEL SEBAGAI BAHAN PENUNDA KEMATANGAN [Physicochemical Changes of Ambon Curup Banana (Musa sapientum c.v. Ambon Curup) During Storage Using Ca(OH)2-Silica Gel as Material for Delaying Rippening]
Authors: Efendi Zulman , Hidayat Lukman 
Published: October 2018

Ambon Curup Banana is a local banana fruit grown in Rejang Lebong Regency, Bengkulu Province which has a short shelf life due to no material addition for delaying rippening. This study was conducted to evaluate the physicochemical changes of ‘Ambon Curup’ banana during storage with absorber of Ca(OH)2 and silica gel treatments. The research was conducted in a completely randomized design of one factor namely the composition of absorber Ca(OH)2 -silica gel: 0-0, 0-4, 0-8, 1-0, 1-4, 1-8, 3-0, 3-4 and 3-8 (% w/w) based on banana weight. The results showed that Ca(OH)2 3% with silica gel 4% and 8% were able to retain harder texture, inhibit the weight loss, green degradation, total soluble solid increase, and achieve better shelf life of 24 days at room temperature compared to other treatments.
Andalucía Barroca: Congreso Internacional
Authors: Pazos Bernal Mª de los Ángeles 
Published: October 2018

Adjetivos, como rico, complejo o variado, que suelen emplearse para la caracterización del Barroco, serán válidos también para referirse al conjunto de actos programados para tener desarrollo [...] en el proyecto Andalucía Barroca 2007.
Torres Aguilar, Francisca: El cartel de la Semana Santa de Málaga (1980-2008)
Authors: Sánchez López Juan Antonio 
Published: October 2018

Para bien o para mal, la Semana Santa y todos los aspectos relacionados con ella forman parte, de manera indisoluble, de la idiosincrasia y modus vivendi de Andalucía y, singularmente, de la ciudad de Málaga.
Una posible obra del escultor José Montes de Oca (ca. 1676-1754)
Authors: Porres Benavides Jesús 
Published: October 2018

En los últimos años y especialmente tras la monografía rea- lizada por el tristemente desaparecido Antonio Torrejón, ha crecido el interés por la gura del escultor José Montes de Oca (ca. 1676-1754). Algunas publicaciones y sobre todo la restauración de sus obras han puesto de relieve su produc- ción. Por otra parte, en el ámbito histórico-artístico, podemos comentar que algunas atribuciones que se le han hecho recientemente no son del todo afortunadas.
DAMPAK KONFLIK PERAN TERHADAP STRES DAN KEPUASAN KERJA KARYAWAN PT. JOMBANG INTERMEDIA PRESS (JAWA POS RADAR JOMBANG)
Authors: Juwita Kristin , Arintika Devy 
Published: October 2018

The purpose of this research is to know the effect of role conflict on employee job satisfaction with job stress as a mediation variable at PT. Jombang Intermedia Press (Jawa Pos Radar Jombang). The research used explanatory research with a quantitative approach to explain relationship variables through hypothesis testing. This study uses questionnaires which is distributed to 30 respondents of PT. Jombang Intermedia Pers (Radar Jombang) with saturated sampling method. The analysis method uses SEM (Structural Equation Model) with PLS (Partial Least Square) 3 . The result of data analysis known has significant positive influence between role conflict on work stress. But, role conflict has a positive effect on job satisfaction, work stress positively influence to job satisfaction, while work stress is not able to mediate between role conflict to job satisfaction.
Keyword—Role Conflict, Job Stress, Job Satisfaction
Abstrak
Penelitian ini bertujuan meneliti pengaruh konflik peran terhadap kepuasan kerja karyawan yang dimediasi stres kerja pada PT. Jombang Intermedia Pers (Jawa Pos Radar Jombang). Jenis penelitian adalah penelitian penjelasan (explanatory research) dengan pendekatan kuantitatif. Pengumpulan data menggunakan kuesioner yang disebarkan kepada 30 karyawan PT.Jombang Intermedia Pers (Radar Jombang) dengan metode sampling jenuh. Metode analisis dibantu oleh SEM (Structural equation Model) dengan alat analisis Pls versi 3. Berdasarkan hasil penelitian menunjukan ada pengaruh positif dan signifikan antara konflik peran terhadap stres kerja. Namun, justru konflik peran berdampak positif terhadap kepuasan kerja, stres kerja juga berdampak positif terhadap kepuasan kerja. Adapun stres kerja tidak mampu memediasi pengaruh konflik peran terhadap kepuasan kerja.
Kata Kunci—Konflik Peran, Stres Kerja, Kepuasan Kerja
Rancang ulang mesin penyayat daging sapi untuk bahan baku membuat abon menggunakan motor listrik 1 HP
Authors: Hasrin Hasrin , Zuhaimi Zuhaimi , Sumardi Sumardi 
Published: October 2018

The high consumption of processed beef products is a separate business opportunity to be developed. The shifting consumption pattern of the people in consuming processed beef products from fresh meat to processed products ready to encourage some parties to develop technology in terms of processing beef. In making abon now it is still traditional by using hands, knives or forks to cut the meat after the boiling process until cooked to be made abon. By using such manual equipment of course the process of making abon will take a long time, greater energy, and besides also slicing meat by pounding using a fork is considered less safe for workers. The purpose of this research is to get a tool / machine penyya beef is simpler for raw materials to make abon using electric motor 1 hp. Changes in the redesigned construction consist of: cylinder casing design, inlet and outlet ducts, container tubs and placemats. The result of the test has been tested by 1 kg of beef, thus showing the measured fiber texture measurement results consist of: 0.5 mm thickness, 30 mm length; 1 mm thick, 35 mm long and 1.5 mm thick, 35 mm long. Capacity of beef cultivation yields are: 3.3 ounces / minute or 1 kg / 3 minutes. So it can be concluded the closer the gaps in the cassing, then the result of the incision the better (smoother). Keywords: Meat meat machine, inlet hopper, cylinder case
As garantias constitucionais entre utilidade e substância
Authors: Pereira Jane Reis Gonçalves 
Published: October 2018

O presente artigo discute os limites ao uso de argumentos pragmáticos em decisões que promovem restrições a direitos fundamentais em conflito com metas coletivas. O texto se divide em três partes. Na primeira, examinam-se brevemente as tendências antiformalistas na interpretação contemporânea, tentando situar a emergência do pragmatismo jurídico como escola dotada de relativa autonomia e prestígio. Em sequência, busca-se avaliar de que maneira o uso de argumentos pragmatistas pelos juízes interage com as várias concepções do Estado de Direito. Por fim, a partir do exame de algumas decisões recentes do STF, procura-se estruturar a ideia de que argumentos de ordem pragmática e consequencialista, apesar de inexpugnáveis da interpretação jurídica, não devem ser protagonistas nos cenários em que os direitos entram em conflito com bens ou metas coletivas. Defende-se que o uso da argumentação pragmatista para restringir direitos fundamentais positivados em favor de bens coletivos não apenas é incompatível com as premissas do constitucionalismo brasileiro, como corrói os próprios fundamentos que conferem legitimidade ao uso de métodos criativos pelo Poder Judiciário.
EFEKTIVITAS METODE PEMBELAJARAN SCL (STUDENT CENTERED LEARNING) DAN TCL (TEACHER CENTERED LEARNING) PADA MOTIVASI INSTRINSIK & EKSTRINSIK MAHASISWA PSIKOLOGI UNTAG SURABAYA ANGKATAN TAHUN 2014 â€“ 2015
Authors: Ramadhani Hetti Sari 
Published: October 2018

AbstractÂ Â Â Â Â Â Â Â Â Â Â Â His study aims to see the effectiveness of learning methods scl (student center learning) and tcl (teacher center learning) on intrinsic & extrinsic motivation student psychology UNTAG Surabaya Year 2014-2015. The research subjects took random sampling of 100 students from the class of 2014 and 2015. The intrinsic and extrinsic motivation scales used consisted of 21 valid and reliable items. The data were analyzed using Independent Sample T Test test which had previously tested normality and homogeneity. Based on the calculation result known Sig value. 0,946> 0,05 meaning that there is no difference of intrinsic motivation and extrinsic motivation at UNTAG student of psychology class of 2014 and 2015 which received learning method scl (student center learning) and tcl (teacher center learning).Â Keyword: intrinsic & extrinsic motivation, scl (student center learning) and tcl (teacher center learning)
Retóricas de la corporalidad en un archivo de relatos orales argentinos
Authors: Palleiro Maria Ines 
Published: October 2018

Me ocupo aquí de la retórica de la corporalidad en relatos orales que recopilé en investigaciones de campo en La Rioja, Argentina, relacionados con la mutilación corporal. Los agrupo en torno a matrices folklóricas, como modalidad de ordenamiento para identificar una poética de condensaciones metafóricas y desplazamientos metonímicos, en una tensión entre una lógica sinecdótica de fragmentación y la restauración simbólica de una completud corporal.Vinculo tal retórica de la corporalidad con la configuración de identidades sociales, en las matrices “El mundo de abajo”, “Cairé” y “La niña sin brazos”. Examino la recontextualización de estas matrices en el contexto riojano, y destaco el valor del trabajo etnográfico para detectar conexiones intertextuales con creencias locales, que remiten a un modelo cosmovisional.
DESAIN PEMBELAJARAN KOOPERATIF BERBASIS TEORI BRUNER UNTUK MENINGKATKAN KUALITAS PEMBELAJARAN MATEMATIKA
Authors: Yusri Yunarni , Arifin Sadriwati 
Published: October 2018

Jenis penelitian adalah desain research yang bertujuan untuk mendesain pembelajaran, khususnya perangkat yang digunakan dengan model pembelajaran kooperatif berbasis teori Bruner pada pokok bahasan kubus dan balok yang meliputi Rencana Pelaksanaan Pembelajaran, Buku Siswa, dan Lembar Kerja Siswa. Subjek penelitian ini adalah siswa kelas VIIISMP Negeri 1 Labakkang sebanyak 30 orang. Prosedur desain yang digunakan siklus Mc. Kenney yang dipadukan dengan model Dick & Carey yang meliputi 3 tahap, yaitu Preliminary design, Prototyping phase, dan assessment phase. Perangkat pembelajaran kooperatif berbasis teori Bruner yang telah didesain telah divalidasi dan direvisi tiga kali sehingga layak untuk digunakan. Hasil dari ujicoba terbatas menunjukkan bahwa perangkat pembelajaran kooperatif berbasis teori Bruner bersifat efektif dan praktis, yaitu (1) skor rata-rata yang diperoleh siswa pada tes hasil belajar adalah 76,87 dari skor ideal 100 dengan standar deviasi 12,43. Dimana 24 dari 30 siswa atau 80 memenuhi ketuntasan individu yang menunjukkan bahwa ketuntasan klasikal tercapai; (2) dengan menggunakan perangkat pembelajaran kooperatif berbasis teori Bruner, siswa menjadi lebih aktif dalam proses pembelajaran ; (3) pada umumnya siswa memberikan respons positif terhadap kegiatan pembelajaran. Jadi berdasarkan uraian tersebut, dapat disimpulkan bahwa hasil desain pembelajaran pembelajaran kooperatif berbasis teori Bruner di kelas VIII SMP Negeri 1 Labakkang berkualitas.
Optimization Model for Compressive Strength of Sandcrete Blocks Using Cassava Peel Ash (CPA) Blended Cement Mortar as Binder
Authors: Amartey Y. D. , Taku J. K. , Sada B. H. 
Published: October 2018

This research work applies Scheffe’s second degree simplex theory to formulate a regression model for the optimization of the compressive strength of sandcrete blocks using cassava peel ash (CPA) blended Portland cement (OPC) as binder material for different mix ratios as multivariate functions with the proportions of the sandcrete block ingredients serving as variables. The experimental values of the compressive strength were obtained by performing destructive strength tests on the blocks after curing for 28 days, with a binder-aggregate ratio of 1:8 and water binder ratio ranging from 0.45 to 0.60, the OPC being replaced with CPA at 0 – 30% for the respective water-binder ratios. The optimization model from the Scheffe’s mixture method for a (4, 2) factor space was found to be y= f(x) = 1.95x1 (2x1-1) + 1.84x2 (2x2-1) +1.81x3 (2x3-1) +1.79x4 (2x4-1) + 6.08x1x2 + 5.72 x1x3 + 1.89 x1x4 + 7.28 x2x3 + 1.80 x2x4 + 7.16 x3x4. The model was tested using the student t- test at 95% accuracy and found to be accurate. Thus, the model can be used to predict any desired compressive strength value for CPA-OPC blended sandcrete blocks given any water-cement ratio between 0.45 and 6.0 and vice versa. Kathmandu University Journal of Science, Engineering and TechnologyVol. 13, No. 2, 2017, page:1-14
Формообразующий процесс как базовая основа логики музыкального мышления.
Authors: Zavgorodnaya Galina 
Published: October 2018

Цель работы рассмотреть процесс формообразования в широком ценностно-смысловом значении как своеобразную основу системы музыкального языка и его элементов. Методология основана на использовании историко-логического метода анализа. У его истоков находится диалектика пространственно-временных координат. Она определяет закономерности существования музыкальной материи и отражает конструктивную и художественно-содержательную логику эволюции композиторского творчества. Научная новизна основана на расширении представлений об исторической роли формообразующего процесса как одного из основных аспектов развития логики музыкального мышления. Особое внимание уделено выразительному аспекту формирования пространственных координат в строении художественной композиции произведений Ю. Гомельской, что раскрывает своеобразие их конструктивной и смысловой направленности. Выводы. Пространственно-временные отношения отражают диалектику жанрово-стилевого диалога в музыке как особом виде художественного творчества.Ключевые слова: Процесс формообразования, пространство, время, композиция, музыкальное мышление, полистилистика, музыкальный язык.
Aplikasi Pendeteksi Tingkat Kesamaan Dokumen Teks: Algoritma Rabin Karp Vs. Winnowing
Authors: Sugiono Sugiono , Herwin Herwin , Hamdani Hamdani , Erlin Erlin 
Published: October 2018

Tindakan copy paste dokumen teks sering terjadi dalam penulisan karya ilmiah tanpa memberikan kredit kepada yang mempunyai dokumen teks tersebut. Tindakan melanggar kode etik ini disebabkan karena tersedianya fasilitas menyalin dan menempel teks pada aplikasi pengolah kata. Tujuan dari penelitian ini adalah untuk membangun sebuah aplikasi yang mampu mendeteksi tingkat kesamaan dokumen teks dengan terlebih dahulu membandingkan tingkat kehandalan dari dua algoritma pendeteksi kesamaan teks yaitu algoritma rabin-karp dan algoritma winnowing. Perbandingan dilakukan terhadap dua variabel yaitu tingkat kemampuan mendeteksi dan waktu pemrosesan. Hasil menunjukkan bawah algoritma winnowing lebih unggul dibandingkan algoritma rabin-karp dari sisi tingkat akurasi maupun dari sisi waktu pemrosesan.
Abstract
The behavior of copy pastes the text document often occurs in scientific writing without giving credit to those who have the text document. The behavior of this missing code of conduct due to the availability of facility to copy and paste the text in a word processing application. The purpose of this study is to build an application that can detect the index of similarity of text documents by first comparing the level of reliability of the two text similarity algorithms, i.e., Rabin-Karp and Winnowing. The comparison is measured based on two variables; the level of capability of detecting and processing time. The result shows that Winnowing algorithm outperforms Rabin-Karp in term of both accuracy and processing time.

Keywords: Rabin-Karp, Winnowing, Plagiarism Detection, Text Similarity
Écrire sa vie: relatos de uma trajetória de pesquisa
Authors: Boto Silva Jocelma 
Published: October 2018

Em Écrire sa vie: du pacte au patrimoine autobiographique, Philippe Lejeune (2015) apresenta, de maneira didática, os principais resultados obtidos ao longo de mais de quarenta anos de estudos sobre os textos autobiográficos. É nesse pequeno volume que conhecemos um pouco da trajetória acadêmica que o transformou, pouco a pouco, em referência quando tratamos das formas de escrita de si. No Brasil, o conhecimento das obras desse pesquisador cresce à medida que avançam os estudos sobre a autobiografia, por isso, consideramos a temática desta resenha fundamental, já que, nela, propomos uma breve apresentação do objetivo de cada capítulo, ao mesmo tempo em que ressaltamos sua relevância teórica. Desse modo, acreditamos poder auxiliar a leitura de pesquisadores em solo nacional.