bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTERNALISASI NILAI PENDIDIKAN MELALUI AKTIVITAS MASYARAKAT SEBAGAI SUMBER BELAJAR ILMU PENGETAHUAN SOSIAL
Authors: Subiyakto Bambang , Mutiani Mutiani 
Published: August 2019

The research purposes are to describe what educational value is in the lives of the Banjar community in Sungai Rangas Ulu village, Kabupaten Banjar; and to describe the contribution of the educational values of the life of the Banjar community in the Sungai Rangas Ulu village, Kabupaten Banjar, as a source of social sciences learning at junior high school. A qualitative approach is used in this research. The technique of collecting the data are interview, observation and documentation. Data analysis starts from the reduction, presentation, and verification of data. The results shows that the dominance of parents in rural communities seems so clear that makes people feel dependent on the presence of parents or elders in the community. Parents are used as role models for community life. Moreover, educational values that arise from life, namely; religious, ethical and social. The form is in the form of; Religious; dominant religious activity, Ethics; inheritance of cultural values from generation to generation, and Social; manifestation of harmonious relations between owners and cultivators of agricultural land. The contribution of educational values and social cciences learning resources is an integrated form of educational value and Social Sciences learning. The resources of Social Sciences learning must be seen as a unified whole in a learning process. Thus, they are practical and effective in the soul and human actions and objectively institutionalize in society.Tujuan penelitian ini adalah mendeskripsikan nilai pendidikan dalam kehidupan masyarakat Banjar di Desa Sungai Rangas Ulu Kabupaten Banjar, dan menggambarkan kontribusi nilai-nilai pendidikan dari kehidupan masyarakat Banjar di Desa Sungai Rangas Ulu Banjar sebagai sumber belajar IPS di SMP. Pendekatan kualitatif digunakan dalam penelitian. Teknik pengumpulan data meliputi; wawancara, observasi dan dokumentasi. Analisis data dimulai dari reduksi, presentasi, dan verifikasi data. Hasil penelitian menggambarkan dominasi orang tua di masyarakat pedesaan tampak begitu jelas sehingga membuat orang merasa tergantung pada kehadiran orang tua atau orang tua di masyarakat. Orang tua digunakan sebagai panutan bagi kehidupan masyarakat. Nilai-nilai pendidikan yang muncul dari kehidupan, yaitu; agama, etis, dan sosial. Bentuknya dalam bentuk; Agama; aktivitas keagamaan yang dominan, Etika; pewarisan nilai-nilai budaya dari generasi ke generasi, dan Sosial; manifestasi hubungan yang harmonis antara pemilik dan penggarap lahan pertanian. Kontribusi nilai-nilai pendidikan dan sumber belajar pembelajaran sosial adalah suatu bentuk integrasi nilai pendidikan dalam pembelajaran sosial. Sumber belajar pembelajaran sosial harus dilihat sebagai kesatuan yang utuh dalam proses pembelajaran. Sebagai kesimpulan, sumber belajar pembelajaran sosial praktis dan efektif dalam jiwa dan tindakan manusia dan secara objektif dilembagakan dalam masyarakat.
Comparative Efficacy of Seven Exercise interventions for Symptoms of depression in college students: a network of meta-analysis
Authors: Guo Shengyu , Li Fuying , Yang Yan , Chen Ling 
Published: August 2019

Abstract
Background Depression among college students is common, exercise interventions are valued as one of the most widely prescribed interventions for depressed college students, however, it is especially difficult for university administrators to determine which exercise intervention is most effective, and efficacy of exercise interventions among depressed college students have not been evaluated. Objectives To systematically review and compare the efficacy of Seven Exercise interventions for Symptoms of depression in college students. Method A network of meta-analysis was conducted to fill the objectives. PubMed, Embase databases, and two Chinese language electronic databases WANFANG and CNKI were searched for the related articles. Eligibility criteria Randomized controlled trials comparing the efficacy of Seven Exercise interventions with usual care of college students with depression were included in the review. Main outcomes The Primary outcome of the present study were standardized mean difference(SMD) and the mean change of depressive symptoms. Results 14 trials were identified, including 2010 depressed college students. The result of direct meta-analysis of this review indicated exercise interventions overall had a significantly lower mean depression scores (SMD=-1.13) when compared with usual care. The result of NMA indicated when comparing with badminton intervention, yoga(SMD=-7.7, 95%CI -14 to -0.93) and tai chi (SMD=-9.4, 95%CI -16 to -2.7) can significantly decrease depression scores of the depressed college students. The rank of seven exercise interventions with respect to efficiently decrease symptom of depressed undergraduates was Tai chi > Yoga > Volleyball > Dance > Run> Basketball> Badminton, respectively. Conclusions Tai chi exhibited the highest probability that became the most efficacy intervention among the comparions, and Yoga showed the second most effectiveness to alleviate depressive symptoms of depressed college students, and dance ranks the third, followed by run, volleyball, basketball, badminton respectively.
Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus
Authors: Gao Meng , Yin Dechun , Chen Jugang , Qu Xiufen 
Published: August 2019

Abstract
Background: Malignant ventricular arrhythmia is one of the main reason of death in acute myocardial infarction. In recent years, more and more attention has been paid to the mechanism of its pathogenesis. In this study we investigated the changes of inflammatory factors in the paraventricular nucleus during acute myocardial infarction and its effect on ventricular stability.
Methods : The rats were divided into control group, myocardial infarction group and drug-administered group to observe how interleukin-6 and its downstream GP130-STAT3 pathway in paraventricular nucleus effect the ventricular stability . All data are expressed as the mean ± SEM. One-way ANOVA was used for comparison between groups, and the LSD test was used for comparison between two groups. p<0.05 was considered statistically significant.
Results : After myocardial infarction (MI), the concentration of inflammatory factor interleukin-6 and the downstream Gp130-STAT3 pathway increased in the PVN. After anti-interleukin-6 antibody and Gp130 inhibitor (SC144) injection into the PVN in MI rats, glutamate increased and GABA decreased in the PVN. We also observed a higher plasma norepinephrine concentration, which increased the vulnerability to ventricular arrhythmias.
Conclusions : Interleukin-6 in PVN plays as protective way in MI .and the Gp130-STAT3 pathway plays a key role in this process. We anticipate that our findings will provide new ideas for the prevention and treatment of arrhythmia after MI.
Husbands’ Experience and Perception of support during labour and childbirth in Tanzania
Authors: Kashaija Denis Kampayana , Mselle Lilian Teddy , Mkoka Dickson Ally 
Published: August 2019

Abstract
Background: A key strategy for reducing the number of women dying from delivery complications is birth preparedness and prevention of maternal complications such as haemorrhages and infections. Involving husbands who are decision makers in the house holds may play role in reducing maternal mortality which is still unacceptably high despite the targeted goal to reduce this mortality up to three quarters as targeted in the MDGs by 2015.This is still addressed in the Sustainable Development Goals (SDGs) of 2015/30
Methodology: Qualitative descriptive study design was employed; involving men aged between 24-63years. Participants under this study were selected purposefully at the clinic and in labour ward of SRRH. The in-depth interview, guided by semi structured interview guide was used to collect the audio recorded and hand written information. Data were analyzed using qualitative content analysis
Results; Nine (9) semi-structured interviews conducted with husbands of women attended for antenatal care and those came for deliveries. Four themes emerged; Demonstrating love and affection, Men’s adoption with modern life style, Observing women’s right and Meeting social economic difficulties. Husbands’ support to their partners a good behavior practiced during matrimonial lives. Husbands who support their partners during pregnancy and delivery consider themselves as being modern men as they take home duties beside their usual tasks to let their partners rest during pregnancy. Men are constrained by poor infrastructures of roads that makes difficult with transport from home to the hospital especially when labour is imminent. Ward infrastructures are not supportive to men when they come with their partners.
Conclusion and Recommendations; Men have a significant role in safe deliveries and in maternal health at large. Our health care settings should be made to accommodate men during the routine antenatal and prenatal care for the positive outcome of labour and delivery.
More education to males is needed, either in groups or through media on the importance of male involvement in reproductive and child health issues. Further research is recommended to focus on exploring on how educations, urbanization and globalization variations affect male involvement in maternal and child health specifically in urban communities.
Neuronal migration genes and a familial translocation t(3;17): which genes are implicated in the phenotype?
Authors: AMOR Meriam HADJ , Dimassi Sarra , Hannachi Hanen , Taj Amel , Mlika Adnene , Helal Khaled Ben , Saad Ali , Mougou-Zerelli Soumaya 
Published: August 2019

Abstract
Background: While Miller-Dieker syndrome critical region deletions are well known delineated anomalies, submicroscopic duplications in this region have recently emerged as a new distinctive syndrome. So far, only few cases have been described overlapping 17p13.3 duplications.
Methods: In this study, we report on clinical and cytogenetic characterization of two new cases involving 17p13.3 and 3p26 chromosomal regions in two sisters with familial history of lissencephaly. Fluorescent In Situ Hybridization and array Comparative Genomic Hybridization were performed.
Results: A deletion including the critical region of the Miller-Dieker syndrome of at least 2,9 Mb and a duplication of at least 3,6 Mb on the short arm of chromosome 3 were highlighted in one case. The opposite rearrangements, duplication 17p13.3 and deletion 3p were seen in the second case. This double chromosome aberration is the result of an adjacent 1:1 meiotic segregation of a maternal reciprocal translocation t(3;17)(p26.2;p13.3).
Conclusions: 17p13.3 and 3p26 deletions have a clear range of phenotypic features while duplications still have uncertain clinical significance. However, we could suggest that regardless of the type of the rearrangement, the gene dosage and interactions of CNTN4, CNTN6 and CHL1 in the 3p26 and PAFAH1B1, YWHAE in 17p13.3 could result in different clinical spectrums.
Serum proteomics analysis reveals the thermal fitness of dairy buffalo to chronic heat stress
Authors: Ping Liu , Lulu Guo , Huaming Mao , Zhaobing Gu 
Published: August 2019

Abstract
Background: Chronic heat stress (CHS), aggravated by global warming, reduces the production efficiency of the buffalo dairy industry. CHS changes protein abundance, and low-abundant proteins take important roles in biological processes.

Results: The objective of the study was to assess differences in low-abundant serum proteins in dairy buffaloes at thermoneutral (TN) or under chronic heat stress (CHS) conditions with proteomic approaches. Six dairy buffaloes as reference animal raised in TN season, and another six dairy buffaloes raised in CHS to discover the molecular mechanism of thermal fitness in hot season with serum proteomics. After the removal of multiple high-abundant proteins in serum, 344 low-abundant proteins were identified in serum with label-free quantification. Of these, 17 low-abundant differentially expressed serum proteins with known functions were detected, and five of these differentially expressed proteins were validated with parallel reaction monitoring. These five proteins were associated with various aspects of heat stress, including decreased heat production, increased blood oxygen delivery, and enhanced natural disease resistance.

Conclusions: Lipase (LPL), glutathione peroxidase 3 (GPX3), cathelicidin-2 (CATHL2), ceruloplasmin (CP), and hemoglobin subunit alpha 1 (HBA1) were shown to play cooperative roles in CHS fitness in dairy buffalo. Dairy buffaloes adapt to CHS and hypoxia with high levels of RBCs, HBA1 and CP increased blood oxygen delivery capacity and thermal fitness.
Awareness of ADHD in primary care: stakeholder perspectives
Authors: French Blandine , Perez-Vallejos Elvira , Sayal Kapil , Daley David 
Published: August 2019

Abstract
Background

Attention Deficit Hyperactivity Disorder (ADHD) is underdiagnosed in many European countries and the process of accessing care and diagnosis is complex and variable. In many countries, general practitioners (GPs) refer on to secondary care where individuals receive an assessment and, if appropriate, a diagnosis and access to care. It is therefore essential that GPs have a clear understanding of the disorder and its care pathways. While previous studies have highlighted potential barriers in GPs’ ADHD awareness, this qualitative study aims to further explore individual stakeholders’ experiences.

Methods

Semi-structured interviews explored the views of multiple stakeholders- GPs (n=5), healthcare specialists (n=5) and patients (adults with ADHD n=5), (parents n=5) and with experience of the presentation and management of ADHD in primary care. These interviews were analysed using thematic analyses and following principles of grounded theory.

Results

Stakeholders described ADHD assessment, diagnosis and treatment as an intricate process. Many factors affected this process such as complex pathways, lack of services, limited GP recognition and knowledge, and communicative difficulties between and within multiple stakeholders.

Conclusion

This analysis underlines the significant impact that receiving (or not) a diagnosis can have, and further explores muddled ADHD care pathways, highlighting key issues around GP identification and the shortage of adult services. Implications for practice and future research are discussed, suggesting a strong need for more commissioned pathways and GP specific educational programs.
Impact of NPS MedicineWise General Practitioner education programs and Choosing Wisely Australia recommendations on prescribing of Proton Pump Inhibitors in Australia
Authors: Wu Jianyun , Dickinson Scott , Elgebaly Zain , Blogg Suzanne Gaye , Heaney Aine , Soo Yien , Daniels Benjamin , Weekes Lynn 
Published: August 2019

Abstract
Background

This study evaluated the impact of multifaceted NPS MedicineWise programs conducted in 2009 and 2015 that targeted general practitioners (GPs) to reduce unnecessary prescribing of proton pump inhibitors (PPIs).

Methods

Time series analyses of the dispensing rates of concessional PPI scripts between January 2006 and June 2016 using the Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) databases in Australia. Participants were GPs with dispensed PPI prescriptions to concessional patients between January 2006 and June 2016. The interventions were National NPS MedicineWise PPI educational programs in 2009 and 2015 delivered to all practising GPs in Australia. The 2015 intervention coincided with the release of Choosing Wisely Australia recommendations from the RACGP. Outcome measures included monthly dispensing rates of standard and low strength PPIs prescribed by GPs among concessional patients in Australia.

Results

Following the 2009 NPS MedicineWise program we observed a 6.7% reduction in the expected dispensing rate of standard strength PPIs among concessional patients between January 2006 and March 2015, and a total 8.6% reduction by June 2016 following the launch of the 2015 program. We observed a significant increase of 5.6% in the expected dispensing rate of low strength PPIs among concessional patients between April 2009 and March 2015, and no significant change in trend following the 2015 program.

Conclusions

The NPS MedicineWise programs were associated with reductions in the dispensing rate of standard strength PPIs, and with an increase in the dispensing rate of low-strength PPIs by June 2016. Although the rate of high-strength PPI prescribing is declining, these formulations still constitute the majority of PPI use in Australia. Regular interventions to sustain and improve PPI management by GPs may be warranted.
Quality of life and project of cancer patients in Colombia, a strategy for the creation of a public policy
Authors: Romero-Prada Martin , Chaves Rafael , Ocampo Maria Victoria Victoria , Gallo Duvan , Huerfano Lina Maria 
Published: August 2019

Abstract
Background: The quality of life related to health and the outcomes perceived by cancer patients, is a concept that allows knowing the patient's perception of their health situation and the conditions associated with these. This study is part of the PROCAN strategy, originally devised as response to deficiencies in state policies aimed to assess the health condition of cancer patients and the difficulties which arise while posing multidimensional interventions designed to better a patient’s quality of life. Methods: A cross-sectional study was developed in a representative sample of cancer patients in Colombia, in which the standardized generalized instrument EQ5D3L and a specific instrument called EORTC QLQ-C30 were applied. The characterization data of the population were analyzed by descriptive statistics. Results: The defined scales were applied to 360 patients. The global health state of the EORTC QLQ-C30 was of 66.05, which compared with the control scale EQ5D3L was of 0.70 and with the analog visual scale of 69.79. EORTC QLQ-C30 were applied The emotional and social functions were the most affected. And from a symptoms’ perspective, financial difficulties created the greatest impact (52.8), followed by insomnia and fatigue, all of which were above pain. Conclusions: Therefore, what this study intents to achieve is the promotion of the use of measurements of a cancer patient’s quality of life with the purpose of, in the first place, developing process that would mitigate the damage to the most affected dimensions with the focused pathology, and the development of follow-up actions within the Colombian social security services that would aid the evaluation of proposed strategies after the original assessment of a cancer patient’s quality of life.
Effect of Clinical Use and Sterilization Process on the Transition Temperature Range of Thermally NiTi Alloys
Authors: da Silva Vieira Bruno , Cançado Rodrigo H. , Freitas Karina M.S. , Valarelli Fabrício P. , Gobbi Renata C. , de Oliveira Ricardo C. Gobbi 
Published: August 2019

Background:
Thermally activated nickel-titanium wires have been widely used by orthodontists due to more constant forces, generation over longer activation spans, greater resistance to permanent deformation, superelasticity characteristics when cyclically loaded, better spring-back and less hysteresis.

Objective:
The purpose of this study was to evaluate the influence of clinical use and sterilization process on the Transition Temperature Range (TTR) of thermoset nickel-titanium wires using Differential Scanning Calorimetry (DSC).

Methods:
Sections from four nickel-titanium wires (0.019 × 0.025-inch) belonging to four different brands were assessed in four different states. Two of the wires were assessed in the “as received” state, one after 60 days of clinical use, and one after 60 days of clinical use and subjected to a sterilization process (autoclaving). The segments of each archwire were tested using DSC at temperatures ranging from −80°C to 150°C at a rate of 10°C/min.

Results:
All the nickel-titanium memory thermoset wires presented with desirable property for clinical use. The shape memory property was not influenced by clinical use and sterilization process.

Conclusion:
There was no change in TTR of the nickel-titanium wires after clinical use and sterilization.
M-Type Phospholipase A2 Receptor Staining in Children with Idiopathic Membranous Nephropathy: PLA2R Staining in Children with IMN
Authors: Inaguma Yosuke , Shiratori Atsutoshi , Nakagawa Taku , Kanda Kyoko , Yoshida Makiko , Hara Shigeo , Kaito Hiroshi , Nozu Kandai , Iijima Kazumoto , Yoshikawa Norishige , Tanaka Ryojiro 
Published: August 2019

Background:
Membranous Nephropathy (MN) is a common cause of nephrotic syndrome in adults that can also occur in children, albeit less frequently. Recently, the M-type phospholipase A2 receptor (PLA2R) was identified as the target antigen in idiopathic membranous nephropathy (IMN), making it a useful marker for diagnosis. However, there are few studies describing the potential role of PLA2R in children with IMN. The aim of this study was to clarify the involvement of PLA2R in childhood IMN.

Methods:
We enrolled 11 patients diagnosed with IMN from January 1998 to March 2017. We performed PLA2R staining in paraffin-embedded renal biopsy sections. The clinical data were collected from the patients’ medical records.

Results:
The median age at biopsy was 6 years (range, 4 to 14 years). A single 6-year-old boy among all pediatric patients with IMN had granular PLA2R staining along his glomerular capillary loops and the prevalence of PLA2R-positivity was 9%. He also showed IgG4 co-dominant staining in terms of IgG subclass. There were no apparent differences in his clinical features such as clinical data at the time of renal biopsy, the time from the treatment initiation to remission, and relapse or renal dysfunction during the follow-up period.

Conclusion:
We suggest that PLA2R staining can be a diagnostic tool for patients with IMN of any age, though pediatric patients with IMN have lower prevalence of PLA2R-positive staining than adult patients.
Pharmacokinetics and Systems Pharmacology of Anti-CD47 Macrophage Immune Checkpoint Inhibitor Hu5F9-G4
Authors: Mishra Adarsh , Kataria Ishant , Nair Sujit 
Published: August 2019

Background:
Hu5F9-G4, a human immunoglobulin G4 (IgG4) monoclonal antibody
(mAb) has recently been granted fast-track designation by the FDA for the treatment
of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and follicular
lymphoma. Hu5F9-G4 has the ability to block CD47-SIRPα signaling along with anti-
EGFR and anti-PD-L1 immune checkpoint activity that is involved in a variety of cancers
like solid tumors, Non-Hodgkin’s Lymphoma (NHL), colorectal cancer (CRC), breast,
ovarian and bladder cancers, and hematological malignancies. Thus, Hu5F9-G4 is an important
biologic that has increasing clinical relevance in cancer care.

Methods:
We queried PubMed, Web of Science, Google Scholar, Science Direct and Scopus
databases with keywords pertaining to Hu5F9-G4. In addition, we have included the
Hu5F9-G4 data presented at the 60th American Society of Hematology (ASH) Annual
Meeting, the American Society of Clinical Oncology (ASCO) Annual Meeting and 23rd
Congress of the European Hematology Association (EHA).

Results:
We discuss the mechanistic basis and preclinical evidence for the anticancer activity
of Hu5F9-G4. Further, we delineate clinical studies, alone and in combination with
anti-CD20 mAb rituximab, anti-EGFR mAb cetuximab, PD-L1 checkpoint inhibitors avelumab
and atezolizumab, and anti-HER2 mAb trastuzumab. Moreover, the potential adverse
effects, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 with emphasis on
the role of CD47-SIRPα signaling in phagocytosis are presented.

Conclusions:
Taken together, we review the pharmacokinetics and systems pharmacology
of Hu5F9-G4 which appears to hold great promise for the future of cancer care.