bluuebunny/crossref_metadata_2025_split huggingface dataset:
Third Party Tariff: A Key Input to NOV Projects Decision Analysis & Decision Quality
Authors: Obeahon P. P. , Ikpera C. N. , Laoye A. O. 
Published: July 2019

Abstract
The paper seeks to find the optimum solution on how to develop some portion of a unitized field. The case study involves two fields straddling across four oil mining leases (OMLs), in Niger Delta, Nigeria. Each field were operated independently by JV-A and JV-B until mid-2016 when the operatorship of the straddling reservoirs (SRs) in the unit was granted to JV-B by the regulators, as it is a law in Nigeria that all straddling reservoirs should be developed as a unit under a single operator.
The decision on whether JV-A should grant JV-B the right to also operate the non-straddling reservoirs (NSRs) in the unit will depend on the amount of tariff imposed. JV-A will be required to pay hydrocarbon transportation and processing tariffs if it flows its share of the produced hydrocarbon through JV-B's existing facility. The exact amount of tariff is unknown and will be negotiated. Additionally, four feasible evacuation routes exist and will be considered for this evaluation to decide the most profitable and capital efficient investment option.
The result shows that the opportunity is very sensitive to hydrocarbon handling tariff; necessitating JV-A choice of evacuation route. In addition, the paper demonstrates how using appropriate project framing and considerations of who will operate the JV-A's non-straddling reservoirs, relied heavily on different hydrocarbon transportation and processing tariffs. It is hoped that this paper having highlighted the importance of tariff charges and the role of proper framing on decision quality will encourage decision makers to adopt this approach during decision analysis and ultimately improve the quality of investment decisions particularly for Non-operated venture (NOV) projects.
Effective Barrier Risk Management in Process Safety Utilizing the Bow Tie Methodology
Authors: Abia D. , Iwegbu M. , Onofeghara C. , Anozie I. 
Published: July 2019

Abstract
The outcome of the Technological Risk Assessment is the major risk register that contains all the major incident scenarios including the top ten scenarios and their corresponding barriers towards prevention, control & mitigation of potential consequences. The expected result of an effective Barrier Risk Management is to reduce and or minimize the possibility of a major process safety incident happening due to weaknesses developed in these barriers and ensuring that all the necessary mitigation and mechanisms are robust enough and in place should an incident happen. Are our Barrier risk assessment for process safety accidents properly assessed with adequate barriers defined to prevent the occurrence of major incidents?
This means that, the assurance of Process Safety is defined on the basics that all our Safety Critical Barriers (SCBs) are clearly understood, by knowing what our critical controls are, assessing and monitoring their health status in our day-to-day operations towards ensuring that they are functionally available on demand to prevent, mitigate and control process safety incidents.
This Paper in detail, will describe the operationalization of the Bow Tie Barrier Risk management, beginning with the Identification of Safety Critical Barriers for operating plants in an integrated approach, defining potential threats from major accident scenarios, its effects and their barriers in one holistic view with the BowTie, act as a line of sight for individual barrier performance management, action plans and improvement. Converting the BowTie from a static to a dynamic barrier management tool by identifying any missing or possible degraded barriers and manage corrective actions implementation, plug in other operational elements such as incidents, audits, inspections, change management and safety and inspections information to create relationship between the barriers and any operational disturbances.
Best Practices in Evaluating Production Performance: A Niger Delta Case Study with Inter-Reservoir Communication
Authors: Mogbolu Emmanuel , Awa Chukwunweike , Ekwealor Jude , Jaja Victor , Okereke Onyedikachi 
Published: July 2019

Abstract
Uncertainty management for resource volume of a brown field is relevant. An analytical approach via dynamic model was used to evaluate this impact on a developed gas reservoir (brown) by two other reservoirs. One of them is a green oil-rim reservoir, while the other is a developed oil reservoir. This is due to sand-to-sand juxtaposition with the two reservoirs. Integration of available data over time, while considering all the reservoir uncertainties was adopted. This was buttressed by the continuous production from the gas reservoir, that had already gone past the initially evaluated Gas Initially in Place (GIIP).
The brown reservoir is a highly faulted gas reservoir with twenty-seven (27) years production history, by seven wells. The reservoir's GIIP re-evaluation had been done twice over the years. This was because it had fully developed its ultimate recovery, with three wells still producing. This GIIP re-evaluation approach could no longer be utilized, as it had very good well coverage.
Fault seal analysis, pressure, PVT sample and log data taken over time reveal the likelihood of communication across the stacked reservoirs. A multi-tank material balance model (MBAL) was built via a multidisciplinary approach. The model was history matched using an experimental design approach that saved time and contacts were calibrated. The result showed the quantity of hydrocarbon in both reservoirs that have flowed into the developed gas reservoir. This provides a snapshot on the resource volume impact of the reservoirs with respect to their development and uncertainty management. Revised development plans and resource booking for the reservoirs are also study outcomes. This is relevant for business decisions on resource volume booking and reservoir management.
This approach is a quick win within the Well, Reservoir and Facility Management (WRFM) workspace. Further work by building a 3D simulation model and pressure data acquisition is required for robust benchmarking.
Development of a New High-Pressure High-Temperature Technology for Advanced Screening of Biosurfactants and Injection of Microbes in Porous Rocks during Low-Salinity EOR Processes
Authors: Onyemara Chibuzo C. , Akanji Lateef T. , Ebel Rainer 
Published: July 2019

Abstract
A new high-pressure high temperature (HP-HT) lab-scale rig involving microbial cultivation of pure bacteria strain under reservoir conditions of up to 200 bar and 200°C has been developed. This was accompanied by an extensive laboratory investigation to establish the mechanisms associated with the production and screening of Lipopeptide from pure Bacillus mojavensis NCIMB 13391 strain for the purpose of enhanced oil recovery (EOR) processes. We report for the first time, thermodynamic standard Gibbs free energy required for the Lipopeptide environment friendly biosurfactant (EFBS) formation (ΔGf°) as -2135.1 J.mol−1, and very low brine salinity water (VLBSW) molarity of 0.5096 mg.l− 1. The produced Lipopeptide biomaterial under anaerobic batch cultivation technique generated CMC values of 2.8 mg.l−1 and 2.7 mg.l−1 in deionised water and VLBSW respectively. The dimensionless molecular weight of the produced Lipopeptide biomaterial is 1423.69 and high spontaneity nature of the biomaterial resulting from a more negative ΔGf° value aided the interfacial tension (IFT) reduction of the heavy crude oil and VLBSW system from 15.71 mN.m−1 to 0.04 mN.m−1 at critical micellisation concentration (CMC) of 2.7 mg.l−1 and 65°C under reservoir confined environment, and 1.76 mN.m−1 at 25°C temperature and 55 bar pressure conditions. However, 2.7 mg.l−1 solution molarity, 65°C temperature and 55 bar pressure are recommended as the optimum recovery pilot molarity, temperature and pressure of the screened heavy crude oil material in low-salinity EOR processes.
The protocol to remove high abundant proteins from HIV-1 infected human plasma
Authors: Barik Sushanta Kumar , Mohanty Keshar Kunja , Bisht Deepa , Mohanty Partha Sarathi , Patil Shripad , Singh Rananjaya , Joshi Beenu , Tripathy Srikanth Prasad , Singh Tej Pal , Tandon Rekha , Tomar Sheetal , Jena Srikanta 
Published: July 2019

Abstract
Removal of high abundance protein from human plasma is an advantage during the analysis of protein in SDS-Poly acrylamide gel electrophoresis. We have adopted a protocol for removal of high abundance protein from human plasma by following several previous protocols. The 50% TCA-Acetone is most suitable method for removal of high abundance proteins like albumin and globulin from HIV-1 infected human plasma samples. We have developed this protocol in our laboratory for carrying out the protein work from HIV-1 infected human plasma samples. This protocol is suitable to run the purified human plasma protein for sodium dodecyl sulfate polyacrylamide gel electrophoresis.
Long-term fluoxetine administration induces changes in microtubule plasticity mediated by CRMP2 in differentiated PC12 cells
Authors: Wu Zuotian , Wang Gaohua , Xiao Ling , Wei Yanyan , Wang Huiling , Yang Can 
Published: July 2019

Abstract
Backgroud
Depression is a neuropsychiatric disease with a high risk of relapse. Clinical guidelines advocate whole course of antidepressant treatment, but the relapse rate of MDD is still high.

Methods
We intended to study the changes in microtubule scaffold plasticity induced by long-term antidepressant administration in PC12 cell to explore the possible mechanism of depression relapse.

Results
The cell activity of NC group decreased after 3 days of culture. The results of immunofluorescence showed the extension of processes was obvious on the first day in Flu group and NC group, but neurite connections were inhibited on the third day in Flu group.CRMP2 and Tubulin were co-located by IF, and Co-IP confirmed the interaction between CRMP2 and Tubulin. RT-PCR showed the mRNA expression of CRMP2 and Tubulin increased on the first and second day in Flu group, but decreased on the third day. Similarly, Western Blotting showed the contents of CRMP2 and Tubulin protein in Flu group increased on the first day, but decreased on the third day. The expression of CRMP2 and Tubulin was affected by changes in the activity of CRMP2.

Conclusions
The long-term fluoxetine administration can affect the microtubule scaffold plasticity in PC12 cell, and CRMP2 is involved in this process. This may be one of the biological bases of the high risk for depression relapse induced by long-term antidepressant administration.
Composition and density of soil seed bank in Afar Region, Northeast Ethiopia
Authors: Gemeda Wakshum Shiferaw , Woodmata Sesebe Demissew , M Tamrat Bekele , Betemariam Ermias Aynekulu , mm Wolfgang Pitroff 
Published: July 2019

Abstract
Background: The changeover from seed to plant is a fundamental scheme shaping plant community structure and dynamics. Persistent soil seed banks are significant as it distributes regeneration and succession throughout the year in the vegetation ecosystems following disturbances.
Objectives: The aims of our study were to analyze status of composition and density of soil seed banks (SBs) in West Afar Region, Ethiopia, and effects of Prosopis juliflora (Prosopis) on spatial distribution and densities of SBs.
Methodology: Soil samples were collected under the Prosopis canopies and non-invaded open grazing lands from area of 15cm x 15cm and soil layers of 0-3cm, 3-6cm and 6-9cm.
Findings: It was found that SBs had shown significant variations by districts (χ2 = 5.5, P =0.02) and soil layers (χ2 = 10.5, P =0.01). But, habitats did not show significant effects on SBs (χ2 = 2.3, P =0.13). Higher density of SBs 7065, 8978, and 8444seeds/m2, respectively were recovered from the soil depths of 0-3, 3-6, and 6-9cm at Teru district. On the other hand, lower densities of 311, 0, and 44seeds/m2, respectively SBs were recovered from the soil depths of 0-3, 3-6, and 6-9cm were at Yalo district. Furthermore, SBs under the canopy of Prosopis were less by 93.5% than non-invaded open grazing lands in 0-3cm soil depth. Meanwhile, SBs in 3-6cm soil depth were higher by 79% in non-invaded Prosopis than invaded areas at Teru district.
Conclusions: The overall low density of the SBs in the study areas had implications of poor range land quality for animals to feed on and consequently affects the livelihood incomes obtained from livestock of pastoralists. Thus, conservation of grazing lands, re-seeding of grazing lands, and management of the invasion of the Prosopis are vital measure to sustain the grazing areas in the region.
Comparison of Machine Learning Models and Framingham Risk Score for the prediction of the presence and severity of Coronary Artery Diseases by using Gensini Score
Authors: Wang Yao , Zhu Kangjun , Li Ya , Zhao Liding , Lv Qingbo , Fu Guosheng , Zhang Wenbin 
Published: July 2019

Abstract
Background: The risk prediction model for cardiovascular conditions based on the routine information isn’t established. Machine Learning (ML) models offered opportunities to build a promising and accurate prediction system for the presence and severity of Coronary Artery Diseases (CAD).
Methods: In order to compare the validation of ML models to Framingham Risk Score (FRS), a total of 2608 inpatients (1669 men, 939 women; mean age 63.16 ± 10.72 years) at our hospital from January 2015 to July 2017 were extracted from electronic medical system with 29 attributes. Four different ML algorithms (Logistic Regression (LR), Random Forest (RF), k-Nearest Neighbors (KNN), Artificial Neural Networks (ANN)) were acted to build models, based on eight core risk factors and all factors respectively. The Area Under Curve (AUC) of receiver operating characteristic curve was the significant value to show the prediction power for different models.
Results: According to the AUC, all of ML algorithms had a better prediction validation than FRS for the presence of CAD, specifically, FRS
ERRα promotes gallbladder cancer development via activating PI3K/AKT signaling pathway mediated by Nectin-4
Authors: Wang Lei , Yang Mengmeng , Guo Xingmei , Yang Ziyi , Ji Yuan , Jin Huihan 
Published: July 2019

Abstract
Background: Gallbladder cancer (GBC) is the most common malignant tumour of the bile duct with a poor prognosis. The estrogen-related receptor alpha (ERRα) is a nuclear receptor that has been associated with metabolic processes and cancer progression. Increased ERRα has been shown in endocrine-related cancer and non-endocrine-related cancer. Nevertheless, its role in GBC remains unknown.
Methods: ERRα expression was analyzed by immunohistochemistry in 59 GBC samples. Its association with clinicopathologic characteristics was evaluated. The effect of ERRα on GBC cell proliferation and invasion was evaluated by loss- or gain-of-function assays in vitro and in vivo. The influence of ERRα on EMT biomarkers, Nectin-4 and PI3K/AKT signaling pathway was detected by western blotting. Inhibition of Nectin-4 was conducted to explore the potential mechanism of ERRα in GBC.
Results: Our study reveals increased ERRα expression in GBC tissues vs. non-tumour adjacent tissues. ERRα expression is significantly positively correlated with high TNM stage, high invasion depth and lymph node metastasis, while negatively associated with prognosis. Targeted depletion of ERRα by lentivirus-mediated shRNA decreased cell proliferation in vitro and in vivo. ERRα promoted cancer cell migration and epithelial-mesenchymal transition by regulating the expression of EMT relevant genes. Ectopic expression of ERRα promoted GBC cell growth and invasion in vitro, while inhibiton of Nectin-4 attenuated cell growth and invasion induced by ERRα. Moreover, ERRα overexpression activated the PI3K/AKT signaling pathway while this effect can be blocked by Nectin-4 depletion. Nectin-4 was involved in the oncogenic function of ERRα to activate PI3K/AKT signaling pathway in GBC.
Conclusions: ERRα promotes GBC progression via activating PI3K/AKT signaling pathway mediated by Nectin-4. ERRα may be a potential prognostic factor and molecular therapeutic target for GBC.
A Protocol for the Development of Core Outcome Sets in Pelvic Organ Prolapse Research
Authors: Doumouchtsis Stergios , Rada Maria Patricia , Pergialiotis Vasilios , Falconi Gabriele , Haddad Jorge Milhem , Betschart Cornelia 
Published: July 2019

Abstract
Background
The high prevalence of symptomatic pelvic organ prolapse (POP) and the women's lifetime risk of requiring surgery, as well as the significant impact of POP on women’s health related quality of life has resulted in a variety of studies on POP interventions. A wide variety of outcomes have been reported across randomized trials evaluating interventions for POP and various outcome measures have been used. Such variation leads to a limited value of research to provide reliable evidence-based data for clinical practice guidance. The development and use of a core outcome set (COS) would help to address these issues ensuring outcomes important to all stakeholders, primarily women with POP. We aim to produce, disseminate and implement a COS for POP.
Methods
A steering group within the CHORUS, an International Collaboration for Harmonising Outcomes, Research and Standards in Urogynaecology and Women’s Health will guide the development of this COS. Systematic reviews of trials that reported outcomes and outcome measures on interventions for POP will form the basis for the creation of an outcome inventory. Core outcome selection process will be performed using an international, multi-perspective, online Delphi survey. The modified Delphi method encourages stakeholder group agreement towards consensus core outcomes through repeated reflection and rescoring of items.
Discussion
Dissemination and implementation of the resulting COS within an international context will be promoted. An embedded COS for POP within future studies will most likely be reflected by an increased value of research that provides guidance for clinical practice. The paradigm of the COS development could further inform research priorities in POP treatments, and support clinical guidelines development and better patient care.
KEYWORDS: core outcome sets, outcome measures, pelvic organ prolapse, Delphi survey, randomized trials.
Utilization and associated factors of antenatal care among women who gave birth within the last two years, in Teda Kebele,Gondar town, northwest Ethiopia
Authors: Beyene Fentahun Yenealem , Gubay Amanu 
Published: July 2019

Abstract
Objective

The purpose of this study was to assess utilization and associated factors of antenatal care among women who gave birth within the last two years. Three hundred fifty two participants were selected by simple random sampling technique from April 1-May -27, 2015. Bivariate and multivariate data analysis was performed using SPSS for Windows version 23.

Result

The study identified that 84.4% of respondents were utilized antenatal care.
Comparison of hospital complications and mortality for stroke patients treated by male vs female physicians: a propensity-score matched study
Authors: Lam Fai , Chen Ta-Liang , Lin Chao-Shun , Shih Chun-Chuan , Yeh Chun-Chieh , Hu Chaur-Jong , Chiou Hung-Yi , Liao Chien-Chang 
Published: July 2019

Abstract
Background: The association between physician gender and the outcomes of stroke patients is not yet fully understood. The aim of this study was to evaluate outcomes after stroke hospitalization between patients who received female physicians’ care (FPC) vs male physicians’ care (MPC).
Methods: We used Taiwan’s National Health Insurance Research Database 2000-2009 claims data to conduct a stroke cohort study that included 493,223 hospitalized stroke patients. Using a matching procedure by propensity score, we selected 25,160 stroke patients with FPC and 25,160 stroke patients with MPC for comparison. Logistic regression was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of poststroke complications and in-hospital mortality between patients with FPC and MPC.
Results: Compared with patients with MPC, stroke patients with FPC had significantly lower risks of poststroke pneumonia (OR 0.87, 95% CI 0.81-0.94), septicemia (0.79, 95% CI 0.70-0.88), acute renal failure (OR 0.78, 95% CI 0.65-0.95), admission to the intensive care unit (OR 0.73, 95% CI 0.69-0.77), and 30-day in-hospital mortality (OR 0.64, 95% CI 0.55-0.75). However, the risk of urinary tract infection (OR 1.16, 95% 1.09-1.23) was higher in patients with FPC than in those with MPC. Lower rates of poststroke adverse events in patients with FPC were noted in further analysis, including different morbidities and various types of stroke.
Conclusions: Stroke patients with FPC showed reduced complications and mortality compared with MPC patients. Our findings warrant randomized control trials in the future to validate the influence of physician gender on stroke outcomes.
Evaluation of different immunoassays for the quantitative detection of Epstein–Barr virus capsid antigen immunoglobulin A using a candidate reference
Authors: Chen Hao , Zhong Qiaohua , Wu Xiaobin , Ding Yanling , Chen Qi , Xue Ning , Chen Weizhong , xing shan , xu yiwei 
Published: July 2019

Abstract
Background

As Epstein–Barr capsid antigen (VCA) immunoglobulin A (IgA) detection is widely used for nasopharyngeal carcinoma (NPC),many immunoassays are available for VCA- IgA detection.

Methods

We evaluated the performance of different immunoassays for the quantitative detection of VCA-IgA. Twenty NPC patients were detected VCA-IgA by four ELISA kits and twochemiluminescent immunoassays(CLIA) kits using the reference as a calibration curve. The performance of six kits were evaluated, and the quantitative results were compared.

Results

Our results shown the reference has good linearity in different kits. Without reference, the difference of total CV (from 3.98% to 43.11%) and Within-run CV(from 2.47% to 19.66%) was large in 6 kits. The positive and negative coincidence rate between 6 kits and IFA for NPC diagnosis was 75% overall agreement, but there was a difference among the six kits ranged from 55%-90%. Concentration of samplesdivided into three categories was shown significant difference in certain subgroup of 6 kits. Almost all assays gave a correlation coefficient lower than 0.80, except for Antu and Beier kit and Tarcine kit and New Industries kit.

Conclusions

The reference serum may be used as a reference standard and better compared results from different methods/laboratories.Despite the use of our reference, the quantitative results of each kit are still quite different.We should try to unify the diversity between different antigens to promote the development of VCA-related research in the further.