bluuebunny/crossref_metadata_2025_split huggingface dataset:
A data set of inland lake catchment boundaries for the Qiangtang Plateau
Authors: Yan Denghua , Li Meng , Bi Wuxia , Weng Baisha , Qin Tianling , Wang Jianwei , Do Pierre 
Published: May 2019

AbstractA catchment is the basic unit for studying hydrologic cycle processes and associated climate change impacts. Accurate catchment delineation is essential in the field of hydrology, environment, and meteorology. Traditionally, catchment delineation is most easily carried out where the outflow area can be easily determined because of a well-defined outlet. The obstacle of the current study is to determine accurately the catchment boundary of lakes that are internally draining and, therefore, lack a well-defined outflow (i.e. inland lakes). This study describes a catchment delineation method which demarcated all the catchments of the lakes in the Qiangtang Plateau, especially for the inland lakes and their closed catchments. Lake catchment boundaries determined for the Qiangtang Plateau provide a significant advancement for water resource and climate change evaluation and agriculture production in the area.
A tumor targeting oncolytic adenovirus can improve therapeutic outcomes in chemotherapy resistant metastatic human breast carcinoma
Authors: Sakhawat Ali , Ma Ling , Muhammad Tahir , Khan Aamir Ali , Chen Xuechai , Huang Yinghui 
Published: May 2019

AbstractBreast cancer is the most prevalent malignancy in women, which remains untreatable once metastatic. The treatment of advanced breast cancer is restricted due to chemotherapy resistance. We previously investigated anti-cancer potential of a tumor selective oncolytic adenovirus along with cisplatin in three lung cancer cells; A549, H292, and H661, and found it very efficient. To our surprise, this virotherapy showed remarkable cytotoxicity to chemo-resistant cancer cells. Here, we extended our investigation by using two breast cancer cells and their resistant sublines to further validate CRAd’s anti-resistance properties. Results of in vitro and in vivo analyses recapitulated the similar anti-tumor potential of CRAd. Based on the molecular analysis through qPCR and western blotting, we suggest upregulation of coxsackievirus-adenovirus receptor (CAR) as a selective vulnerability of chemotherapy-resistant tumors. CAR knockdown and overexpression experiments established its important involvement in the success of CRAd-induced tumor inhibition. Additionally, through transwell migration assay we demonstrate that CRAd might have anti-metastatic properties. Mechanistic analysis show that CRAd pre-treatment could reverse epithelial to mesenchymal transition in breast cancer cells, which needs further verification. These insights may prove to be a timely opportunity for the application of CRAd in recurrent drug-resistant cancers.
Compact terahertz detector based on lightweight 3D‐printed lens packaging
Authors: Qiao Haidong , Liu Hao , Mou Jinchao , Liu Songzhuo , Wang Bing , Guo Dalu , Lv Xin 
Published: May 2019

This Letter presents a compact and lightweight terahertz detector with a 3D‐printed lens packaging, exhibiting a high responsivity between 1100 and 2190 V/W from 210 to 230 GHz. The detector is comprised of an antenna‐coupled detector, a 3D‐printed lens and a read‐out circuit. The antenna‐coupled detector with a GaAs Schottky diode is printed on a dielectric laminate. To extract the detected signal more efficiently within a smaller footprint, a pair of folded lines with high impedance are designed. Moreover, a 3D‐printed nylon lens together with a back‐shorting reflector is proposed for radiation gain enhancement and mechanical robustness. A maximum voltage responsivity Rv of 2190 V/W and a minimum noise equivalent power of 2.6 pW/√Hz are achieved at 223 GHz. The measured radiation patterns agree well with the simulated results.
Fortgeschrittenes Plattenepithelkarzinom: Komplettremission unter PD-1-Antikörper-Therapie
Authors: Gellrich F. , Beissert S. , Meier F. 
Published: May 2019

ZusammenfassungFür lokal fortgeschrittene oder metastasierte Plattenepithelkarzinome waren die Behandlungsmöglichkeiten bisher begrenzt. Mit Cemiplimab steht ein monoklonaler Antikörper gegen den programmed death-1-Rezeptor (PD-1) zur Verfügung, welcher in Amerika zur Behandlung des lokal fortgeschrittenen oder metastasierten Plattenepithelkarzinoms zugelassen ist. In der vorgestellten Kasuistik wurde ein 74-jähriger Patient aufgrund eines fortgeschrittenen Plattenepithelkarzinoms mit multiplen, teils inoperablen Tumorrezidiven mit Cemiplimab behandelt. Unter der Therapie trat eine Komplettremission ein. Nach Beginn der Therapie wurde der Patient mit Fieber unklarer Genese, epileptischen Anfällen und neurologischen Ausfällen stationär aufgenommen. Eine immunvermittelte Meningoezephalitis wurde diagnostiziert. Unter zeitnaher hochdosierter systemischer Kortikoidtherapie bildeten sich die neurologischen Defizite vollständig zurück.Unter der Therapie mit PD-1-Antikörpern kann auch bei fortgeschrittenen oder metastasierten Plattenepithelkarzinomen eine anhaltende Komplettremission erreicht werden. Unter der Therapie mit Immun-Checkpoint-Inhibitoren können schwere immunvermittelte Nebenwirkungen auftreten. Zeitnahes interdisziplinäres Management mit frühzeitiger Diagnosestellung und Therapieeinleitung sind essenziell, um bleibende Schäden zu verhindern.
Therapie der schweren Psoriasis vulgaris et arthropathica in der Schwangerschaft
Authors: Berndt K. , Schneiderat S. , Heyne S. , Beissert S. , Abraham S. 
Published: May 2019

ZusammenfassungDie Psoriasis vulgaris stellt eine häufige, chronisch entzündliche Hauterkrankung dar. Bis zu einem Drittel der Betroffenen leiden zusätzlich unter Psoriasis-Arthritis, einhergehend mit schmerzhaften Gelenkentzündungen, die unbehandelt zur Gelenksdestruktion führen können 1. Trotz eines enormen Fortschritts in den Möglichkeiten der Systemtherapie stellen schwere Verläufe, insbesondere in der Schwangerschaft, immer noch eine Herausforderung dar. Wir berichten über den Fall einer 32-jährigen schwangeren Patientin mit seit dem Jugendalter bestehender, schwerer Psoriasis vulgaris et arthropathica. Unter kombinierter Lokal-, UV- sowie Systemtherapie mit Certolizumab pegol (Cimzia®) konnte eine stabile Krankheitskontrolle erreicht und in der 40. Schwangerschaftswoche ein gesundes Mädchen entbunden werden.
The Terroir of Cannabis: Terpene Metabolomics as a Tool to Understand Cannabis sativa Selections
Authors: Mudge Elizabeth M. , Brown Paula N. , Murch Susan J. 
Published: May 2019

AbstractThe phytochemical diversity of Cannabis chemovars is not well understood, and many chemovars were created in informal breeding programs without records of parentage or the criteria for selection. Key criteria for selection sometimes included aroma notes and visual cues, which some breeders associated with pharmacological activity. We hypothesized that the process of selection for scents believed to be related to specific tetrahydrocannabinol levels has resulted in modified terpene biosynthesis in these chemovars. Thirty-two cannabinoids, 29 monoterpenes and 38 sesquiterpenes were measured in 33 chemovars from 5 licensed producers. A classification system based on cannabinoid content was used with targeted metabolomic tools to determine relationships in the phytochemistry. Three monoterpenes, limonene, β-myrcene, and α-pinene, and two sesquiterpenes, caryophyllene and humulene, were abundant in the majority of chemovars. Nine terpenes were present in tetrahydrocannabinol-dominant chemovars. Three monoterpenes and four sesquiterpenes were predominantly found in cannabidiol-containing chemovars. Low abundance terpenes may have been the aromatic cues identified by breeders. The medicinal activity of some of the terpenes is likely to contribute to the pharmacological effect of specific chemovars. Together, these data demonstrate the synergy of compounds in Cannabis chemovars and point to the need for additional research to understand the phytochemical complexity.
Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis
Authors: Rondon Araci M. R. , Kroone Chantal , Kapteijn Maaike Y. , Versteeg Henri H. , Buijs Jeroen T. 
Published: May 2019

AbstractIt has been long-established that cancer and thrombosis are linked, but the exact underlying pathological mechanism remains to be unraveled. As the initiator of the coagulation cascade, the transmembrane glycoprotein tissue factor (TF) has been intensely investigated for its role in cancer-associated thrombosis and cancer progression. TF expression is regulated by both specific oncogenes and environmental factors, and it is shown to regulate primary growth and metastasis formation in a variety of cancer models. In clinical studies, TF has been shown to be overexpressed in most cancer types and is strongly associated with disease progression. While TF clearly associates with cancer progression, a prominent role for TF in the development of cancer-associated thrombosis is less clear. The current concept is that cancer-associated thrombosis is associated with the secretion of tumor-derived TF-positive extracellular vesicles in certain tumor types. To date, many therapeutic strategies to target TF—both in preclinical and clinical phase—are being pursued, including targeting TF or the TF:FVIIa complex by itself or by exploiting TF as a docking molecule to deliver cytotoxic compounds to the tumor. In this review, the authors summarize the current understanding of the role of TF in both cancer progression and cancer-associated thrombosis, and discuss novel insights on TF as a therapeutic target as well as a biomarker for cancer progression and VTE.
Convergence of formal Dulac series satisfying an algebraic ordinary differential equation
Authors: Gontsov R. R. , Goryuchkina I. V. 
Published: May 2019

Abstract
A sufficient condition is proposed which ensures that a Dulac series that formally satisfies an algebraic ordinary differential equation (ODE) is convergent. Such formal solutions of algebraic ODEs are quite common: in particular, the Painlevé III, V and VI equations have formal solutions given by Dulac series; they are convergent in view of the sufficient condition presented.
Bibliography: 13 titles.
Full squat produces greater neuromuscular and functional adaptations and lower pain than partial squats after prolonged resistance training
Authors: Pallarés Jesús G. , Cava Alejandro M. , Courel‐Ibáñez Javier , González‐Badillo Juan José , Morán‐Navarro Ricardo 
Published: May 2019

AbstractThe choice of the optimal squatting depth for resistance training (RT) has been a matter of debate for decades and is still controversial. In this study, fifty‐three resistance‐trained men were randomly assigned to one of four training groups: full squat (F‐SQ), parallel squat (P‐SQ), half squat (H‐SQ), and Control (training cessation). Experimental groups completed a 10‐week velocity‐based RT programme using the same relative load (linear periodization from 60% to 80% 1RM), only differing in the depth of the squat trained. The individual range of motion and spinal curvatures for each squat variation were determined in the familiarization and subsequently replicated in every lift during the training and testing sessions. Neuromuscular adaptations were evaluated by one‐repetition maximum strength (1RM) and mean propulsive velocity (MPV) at each squatting depth. Functional performance was assessed by countermovement jump, 20‐m sprint and Wingate tests. Physical functional disability included pain and stiffness records. F‐SQ was the only group that increased 1RM and MPV in the three squat variations (ES = 0.77–2.36), and achieved the highest functional performance (ES = 0.35–0.85). P‐SQ group obtained the second best results (ES = 0.15–0.56). H‐SQ produced no increments in neuromuscular and functional performance (ES = −0.11–0.28) and was the only group reporting significant increases in pain, stiffness and physical functional disability (ES = 1.21–0.87). Controls declined on all tests (ES = 0.02–1.32). We recommend using F‐SQ or P‐SQ exercises to improve strength and functional performance in well‐trained athletes. In turn, the use of H‐SQ is inadvisable due to the limited performance improvements and the increments in pain and discomfort after continued training.
Selective probing of magnetic order on Tb and Ir sites in stuffed Tb2Ir2O7  using resonant x-ray scattering
Authors: Donnerer C , Rahn M C , Schierle E , Perry R S , Veiga L S I , Nisbet G , Collins S P , Prabhakaran D , Boothroyd A T , McMorrow D F 
Published: May 2019

Abstract
We study the magnetic structure of the ‘stuffed’ (Tb-rich) pyrochlore iridate Tb2+x
Ir2−x
O7−y
(x ∼ 0.18), using resonant elastic x-ray scattering (REXS). In order to disentangle contributions from Tb and Ir magnetic sublattices, experiments were performed at the Ir L
3 and Tb M
5 edges, which provide selective sensitivity to Ir 5d and Tb 4f  magnetic moments, respectively. At the Ir L
3 edge, we found the onset of long-range

magnetic order below

K, consistent with the expected signal of all-in all-out (AIAO) magnetic order. Using a single-ion model to calculate REXS cross-sections, we estimate an ordered magnetic moment of

at 5 K. At the Tb M
5 edge, long-range

magnetic order appeared below  ∼

K, also consistent with an AIAO magnetic structure on the Tb site. Additional insight into the magnetism of the Tb sublattice is gleaned from measurements at the M
5 edge in applied magnetic fields up to 6 T, which is found to completely suppress the Tb AIAO magnetic order. In zero applied field, the observed gradual onset of the Tb sublattice magnetisation with temperature suggests that it is induced by the magnetic order on the Ir site. The persistence of AIAO magnetic order, despite the greatly reduced ordering temperature and moment size compared to stoichiometric Tb2Ir2O7, for which

K and

, indicates that stuffing could be a viable means of tuning the strength of electronic correlations, thereby potentially offering a new strategy to achieve topologically non-trivial band crossings in pyrochlore iridates.
Regional connectivity and spatial densities of drifting fish aggregating devices, simulated from fishing events in the Western and Central Pacific Ocean
Authors: Scutt Phillips J , Escalle L , Pilling G , Sen Gupta A , van Sebille E 
Published: May 2019

Abstract
The increased use of drifting Fish Aggregating Devices (dFADs) by tuna purse seine fleets in recent years has supported considerable catches of these species. A greater understanding of the spatiotemporal dynamics of these objects as they drift with ocean currents is critical for understanding historical changes in fishing power, spatial management, and examining the effect of ambient dFAD density on catch and effort. Here, dFAD dynamics were estimated for all floating object sets made by purse seiners in the Western and Central Pacific Ocean during 2016 and 2017. The drift trajectories of these floating objects prior to the observed fishing events were estimated by seeding virtual Lagrangian particles within a state-of-the-art hydrodynamics model, and simulating their movements backwards in time. Resulting trajectory distributions are similar to observed dFAD trajectories from the same period. The approach provides spatial density estimates in areas where observed dFAD data are incomplete, particularly in the exclusive economic zone (EEZ) of Howland and Baker Islands, and certain high seas areas. We provide estimates of inter-EEZ connectivity of dFADs, which highlight the fact that dFADs set upon in small EEZs such as Nauru and Howland and Baker Islands are likely to have drifted from neighbouring EEZs less than one month prior to fishing. dFADs typically transited multiple EEZs, with a median of 4 and a maximum of 14, when assuming a drift-time of six months. Moreover, between 4 and 22% of dFAD sets made in the WCPO were estimated to have originated from the Eastern Pacific Ocean, depending on drift-time. We examine our results in the context of the improved management and assessment of dFAD fisheries, providing a methodology to estimated relative dFAD density over historical periods to support analyses of catch and effort. The sensitivity of these estimates to hydrodynamic models, including the proposed SKIM doppler radar altimetry method, is discussed.
The Gender Pay Gap in Academia: Evidence from the Ohio State University
Authors: Chen Joyce J. , Crown Daniel 
Published: May 2019

AbstractWe utilize human resources data from The Ohio State University to assess the gender wage gap. We find a persistent gap of 11% among regular, tenure‐track faculty after accounting for fiscal year, race, clinical appointments, experience, and department. While the presence of a statistically significant gender wage gap is robust, the magnitude of the gap varies substantially depending on how the sample of interest is defined. In assessing gender wage gaps, researchers and universities must be attentive to issues of attrition and classification. Transparency regarding how estimates are affected by sample exclusions and variable definitions will yield insight into possible sources of gender bias.
How Plastic Surgeons Value Professionalism: Using Q Methodology to Explore the Prioritization of Professionalism
Authors: Chiu Chiung-hsuan , Pan Su-chin , Lin Yi-chieh 
Published: May 2019

Abstract

Background
Medicine is no longer limited to the treatment of diseases—the use of plastic surgical techniques as a commodity to improve the appearance of healthy people has become a trend, and plastic surgeons who invest in the market of cosmetic medicine have quickly gained considerable benefits. Will the transformation of the role of plastic surgeons from aesthetic restoration to commercial embellishment damage the creation and maintenance of their sense of professionalism?

Objectives
The purpose of this study was to determine, by utilizing Q methodology, which aspects of professionalism plastic surgeons value.

Methods
Q methodology is a mixed research method employed to study subjectivity through factor analysis. This study analyzes a rank-ordering of participants’ level of agreement with a set of subjective statements related to a given topic. Q statements were developed on the basis of a literature review, expert panels, and medical organizations’ codes of conduct. After face and construct validity checks, as well as a pilot test, we interviewed 31 attending plastic surgeons. Data were collected from April to May 2017.

Results
This study concluded that the main types of medical professionalism held by the respondents can be represented in 4 factors: (1) mastery of clinical skills, (2) leadership and management, (3) knowledge sharing, and (4) multifaceted.

Conclusions
Respondents in this study highly emphasized surgical skill and sought to maintain good relationships with their patients based on their settings. Although they were reluctant to place community service as a top priority, our respondents tended to emphasize the healer aspect over commercialization.
Efficient haplotype matching between a query and a panel for genealogical search
Authors: Naseri Ardalan , Holzhauser Erwin , Zhi Degui , Zhang Shaojie 
Published: May 2019

Abstract

Motivation
With the wide availability of whole-genome genotype data, there is an increasing need for conducting genetic genealogical searches efficiently. Computationally, this task amounts to identifying shared DNA segments between a query individual and a very large panel containing millions of haplotypes. The celebrated Positional Burrows-Wheeler Transform (PBWT) data structure is a pre-computed index of the panel that enables constant time matching at each position between one haplotype and an arbitrarily large panel. However, the existing algorithm (Durbin’s Algorithm 5) can only identify set-maximal matches, the longest matches ending at any location in a panel, while in real genealogical search scenarios, multiple ‘good enough’ matches are desired.

Results
In this work, we developed two algorithmic extensions of Durbin’s Algorithm 5, that can find all L-long matches, matches longer than or equal to a given length L, between a query and a panel. In the first algorithm, PBWT-Query, we introduce ‘virtual insertion’ of the query into the PBWT matrix of the panel, and then scanning up and down for the PBWT match blocks with length greater than L. In our second algorithm, L-PBWT-Query, we further speed up PBWT-Query by introducing additional data structures that allow us to avoid iterating through blocks of incomplete matches. The efficiency of PBWT-Query and L-PBWT-Query is demonstrated using the simulated data and the UK Biobank data. Our results show that our proposed algorithms can detect related individuals for a given query efficiently in very large cohorts which enables a fast on-line query search.

Availability and implementation
genome.ucf.edu/pbwt-query

Supplementary information
Supplementary data are available at Bioinformatics online.
PathFXweb: a web application for identifying drug safety and efficacy phenotypes
Authors: Wilson Jennifer L , Wong Mike , Chalke Ajinkya , Stepanov Nicholas , Petkovic Dragutin , Altman Russ B 
Published: May 2019

Abstract

Summary
Limited efficacy and intolerable safety limit therapeutic development and identification of potential liabilities earlier in development could significantly improve this process. Computational approaches which aggregate data from multiple sources and consider the drug’s pathways effects could add to identification of these liabilities earlier. Such computational methods must be accessible to a variety of users beyond computational scientists, especially regulators and industry scientists, in order to impact the therapeutic development process. We have previously developed and published PathFX, an algorithm for identifying drug networks and phenotypes for understanding drug associations to safety and efficacy. Here we present a streamlined and easy-to-use PathFX web application that allows users to search for drug networks and associated phenotypes. We have also added visualization, and phenotype clustering to improve functionality and interpretability of PathFXweb.

Availability and implementation
https://www.pathfxweb.net/.

Supplementary information
Supplementary data are available at Bioinformatics online.
‘It’s My Secret Space’: The Benefits of Mindfulness for Social Workers
Authors: Kinman Gail , Grant Louise , Kelly Susan 
Published: May 2019

Abstract
Social workers are at high risk of job-related stress that can impair their well-being and professional practice. Although organisational support is a fundamental requirement, it has been argued that social workers need to develop emotional resilience to help them manage the demands of the job. This mixed method study examines the effects of an eight-week mindfulness training course on several resources previously found to underpin resilience in social workers (emotional self-efficacy, psychological flexibility, reflective ability and self-compassion) together with aspects of well-being relevant to the role (compassion fatigue, compassion satisfaction and perceived stress). Participants’ perceptions of the benefits of mindfulness for their well-being and professional practice are further explored via the content analysis of open-ended questions and semi-structured interviews. Emotional self-efficacy, psychological flexibility and compassion satisfaction increased following the intervention and compassion fatigue and perceived stress were reduced. No significant changes were found in reflective ability and self-compassion. The qualitative data provided greater insight into the potential benefits of mindfulness for the well-being and job performance of social workers and factors that might encourage and discourage its use.