bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Function of Estrogen Receptor β in Endometriosis
Authors: Han Sang Jun , Lee Jiyeun E , Cho Yeon Jean , Park Mi Jin , O’Malley Bert W 
Published: September 2019

Abstract
Estrogen receptor (ER) β plays a critical role in endometriosis progression because cytoplasmic ERβ stimulates proinflammatory signaling in ectopic lesions and prevents apoptosis to promote their survival. However, the role of “nuclear ERβ” in endometriosis progression is not known. This critical knowledge gap obscures our understanding of the full molecular etiology of ERβ-mediated endometriosis progression. To fill this void, we generated an ERβ-regulated transcriptome and ERβ cistrome in ectopic lesions and the eutopic endometrium of mice with endometriosis by using a new endometrium-specific FLAG-tagged human ERβ overexpression mouse model. The integration of these omics data sets revealed that ERβ stimulated the proliferation activities of ectopic lesions and the eutopic endometrium by directly upregulating MYC and E2 transcription factor target genes and genes associated with the G2/M transition. Additionally, ERβ stimulated gene expression associated with TNFα/nuclear factor κB (NF-κB) signaling, epithelial-mesenchymal transition, reactive oxygen species signaling, IL-6/Janus kinase (JAK)/signal transducer and activator of transcription (STAT)3 signaling, and hypoxia signaling and suppressed IFNα signaling in ectopic lesions to enhance endometriosis progression. ERβ also stimulated gene expression associated with the unfolded protein response and IL-6/JAK/STAT3 inhibitory signaling and suppressed TNFα/NF-κB signaling in the eutopic endometrium to cause endometriosis-associated endometrial dysfunction. Therefore, nuclear ERβ-regulated gene networks provide critical clues to understand the molecular etiology and complexity of endometriosis and endometriosis-associated endometrial dysfunction.
Effectiveness of the Hospital Learning Center (Queen Sirikit National Institute of Child Health): Satisfaction with service and parents’ attitudes towards children’s illness
Authors: Fuengfoo Adidsuda , Leelathanaporn Sija , Mekrungcharas Thanyaporn , Sakulnoom Kim , Owjinda Sumitra , Noipong Piyanat , Srinuan Suphawan , Kumjaroen Sarunya , Phonok Natchanan 
Published: September 2019

Background: All children, whether healthy or ill, should have access to equal educational opportunities. Healthcare institutions and hospitals have been approved to work with schools to establish learning centers to provide education to sick children. This study has been conducted to develop a practical model for learning centers in hospitals across Thailand to create equality and ensure valuable human resources for the future. The main goal of this study was to evaluate the effectiveness of a hospital learning center for continuing education of child patients and to determine the factors that are most appropriate study plans, the parents’ attitude about their child’s illness, and the children’s satisfaction with the learning center. Methods: The total sample population was 400, consisting of 200 parents and 200 child patients aged 4 to 18 years. The respondents were given a questionnaire to obtain their feedback using a Likert scale. Results: The most common child patients were those with chronic illness followed by those with common illnesses, and lastly children with developmental problems. All 200 children received continuing education; 20 child patients (10%) who had been evaluated received a modified education plan. After analyzing the results of satisfaction with the learning center, the scores ranged from 4.21 to 5.00 (mean = 4.28, SD = 0.62). Conclusions: Sick children can continue their education at the hospital learning center in Queen Sirikit National Institute of Child Health. Study plans can be modified to suit children with chronic illnesses and developmental problems, children in primary and secondary school, and those requiring prolonged hospitalization. Parents in the study had appropriate attitudes about the disease and education of their children. Sick children gave the highest ratings showing extremely high satisfaction with the hospital learning center.
Trust in Procurement Interactions
Authors: Fugger Nicolas , Katok Elena , Wambach Achim 
Published: September 2019

When complex procurement projects are conducted, it is often not possible to write complete contracts. As a consequence, the relationship between buyer and supplier is important for the success of the project. In this paper we investigate the claim that auctions in procurement can be detrimental for the buyer–supplier relationship, which is in line with the observation that reverse auctions are less frequently conducted if projects are complex. A poor relationship can result in a decrease in trust on the part of the buyer during the sourcing process and an increase in the supplier’s opportunistic behavior following sourcing. We consider a setting in which the winning supplier decides on the level of quality to provide to the buyer, and we compare a standard reverse auction and a buyer-determined reverse auction, both analytically and in the laboratory. We find that the buyer-determined reverse auction can perform better than the standard reverse auction from both the buyer’s and the suppliers’ perspective. In a buyer-determined reverse auction, it may be optimal for the buyer to select the supplier who submitted a higher bid, which may in turn induce this supplier to deliver higher quality. Standard auctions, however, yield lower prices but reduce cooperation. The degree of trust, as reflected by a larger number of transactions and a higher average efficiency of trade, is significantly higher in buyer-determined reverse auctions. Theoretical reasoning based on other-regarding preferences organizes our data well. This paper was accepted by Serguei Netessine, operations management.
Prospective evaluation of parental anxiety related to newborn foot disorder
Authors: Mahan S. T. , Miller P. E. , May C. J. , Kasser J. R. 
Published: September 2019

Purpose The presence of a clubfoot is often found prenatally and some families seek counselling with a specialist. The purpose of this study was to compare the parental anxiety levels in families that: a) knew prenatally and had prenatal counselling; b) knew prenatally but did not seek prenatal counselling; and c) did not know until after delivery. Methods This prospective cohort study evaluated the anxiety of parents as they presented to the paediatric orthopaedic clinic with their newborn with a foot disorder (prior to the diagnostic confirmation of clubfoot). Each family filled out the ‘Pre-visit orthopaedic surgeon questionnaire’ and then after the initial visit with the orthopaedic surgeon (confirming the clubfoot diagnosis) the family filled out the ‘Immediately post-visit orthopaedic surgeon questionnaire’. Through these questionnaires, anxiety level was assessed prior to meeting postnatally with the paediatric orthopaedic specialist, as well as after the meeting and compared across groups. Results A total of 121 parents completed questionnaires: 71% (86/121) confirmed clubfoot; 69% of families (59/86) received prenatal counselling (Group A); 16% (14/86) knew prenatally but had no counselling (Group B); and 15% (13/86) found out at birth (Group C). There was no difference in anxiety levels across groups before (p = 0.78) or after (p = 0.57) meeting with the paediatric orthopaedic surgeon; however, overall anxiety reduced significantly (p < 0.001). Conclusion We found no difference in the anxiety levels of across the three groups. Prenatal counselling for parents of children with likely clubfoot may not decrease parental anxiety, but nonetheless is very appreciated by the families who receive it. Level of Evidence Prognostic Level II
Hypoxia-inducible factor (HIF): how to improve osseointegration in hip arthroplasty secondary to avascular necrosis in sickle cell disease
Authors: George Akintunde , Ellis Marianne , Gill Harinderjit Singh 
Published: September 2019

Many studies in the literature have been carried out to evaluate the various cellular and molecular processes involved in osteogenesis. Angiogenesis and bone formation work closely together in this group of disorders. Hypoxia-inducible factor (HIF) which is stimulated in tissue hypoxia triggers a cascade of molecular processes that helps manage this physiological deficiency. However, there still remains a paucity of knowledge with regard to how sickle cell bone pathology, in particular avascular necrosis, could be altered when it comes to osseointegration at the molecular level. Hypoxia-inducible factor has been identified as key in mediating how cells adapt to molecular oxygen levels. The aim of this review is to further elucidate the physiology of hypoxia-inducible factor with its various pathways and to establish what role this factor could play in altering the disease pathophysiology of avascular necrosis caused by sickle cell disease and in improving osseointegration. This review article also seeks to propose certain research methodology frameworks in exploring how osseointegration could be improved in sickle cell disease patients with total hip replacements and how it could eventually reduce their already increased risk of undergoing revision surgery.Cite this article: EFORT Open Rev 2019;4:567-575. DOI: 10.1302/2058-5241.4.180030
PENGARUH TERAPI TAWA TERHADAP PENURUNAN KECEMASAN PADA NARAPIDANA
Authors: Widyastuti Citra 
Published: September 2019

This study aims to examine whether there is an effect of laughter therapy on reducing anxiety in prisoners. The assumption that was built for the first time in this study was that there was an effect of laughter therapy on reducing anxiety in prisoners. Participants in this study were prisoners who had a sentence of more than one year or known as class B1 prisoners. The sampling technique in data collection used was by random sampling technique. The measuring instrument used is an anxiety scale which amounts to 25 items, taken from aspects of anxiety Jeffry Nefid (2006). The therapy module used is a modification of the module made by Madan Kataria (2004). The data analysis method carried out in this study used the SPSS version 11.05 program facility to test whether there was an effect of laughter therapy on the anxiety of inmates. The T test used shows a very significant effect of laughter therapy on reducing anxiety in prisoners, this can be seen from the value of t = 7, 102. So the research hypothesis is accepted. Penelitian ini memiliki tujuan untuk menguji apakah ada pengaruh terapi tawa terhadap penurunan kecemasan pada narapidana. Asumsi yang dibangun untuk pertama kali dalam penelitian ini adalah ada pengaruh terapi tawa terhadap penurunan kecemasan pada narapidana. Partisipan dalam penelitian ini adalah narapidana yang memiliki masa hukuman diatas satu tahun atau yang dikenal dengan narapidana golongan B1.Teknik sampling dalam pengambilan data yang digunakan adalah dengan Teknik random sampling. Adapun Alat ukur yang digunakan adalah skala kecemasan yang berjumlah 25 aitem, diambil dari aspek-aspek kecemasan Jeffry S Nefid (2006). Modul terapi yang digunakan merupakan modifikasi dari modul yang dibuat oleh Madan Kataria (2004). Metode analisis data yang dilakukan dalam penelitian ini menggunakan fasilitas program SPSS versi 11.05 untuk menguji apakah ada pengaruh terapi tawa terhadap kecemasan ada narapidana. Uji T yang digunakan menunjukkan adanya pengaruh yang sangat signifikan terapi tawa terhadap penurunan kecemasan pada narapidana, hal ini terlihat dari nilai t = 7, 102. Sehingga hipotesis penelitian diterima.
The Production Efficiency and Specific Energy Consumption During Processing of Corn Extrudates with Fresh Vegetables Addition
Authors: Lisiecka Katarzyna , Wójtowicz Agnieszka 
Published: September 2019

Abstract
The aim of the work was to determine the influence of screw speed and variable amounts of fresh vegetable additives on selected aspects of extrusion-cooking of corn-vegetable blends. Corn grit as a basic component was supplemented with a fresh pulp of beetroot, carrot, leek and onion in amounts of 2.5-10% in the recipe. The extrusion-cooking was carried out using a single-screw extruder in the temperature range 120-145°C and extrudates were formed into directly expanded snacks. Two indicators were measured: the production efficiency (Q) and the specific mechanical energy (SME) consumption. As a result of the findings it was noted that the rotational speed of the extruder’s screw showed a greater impact on both production efficiency and SME as compared to the variable amounts of applied additives. A tendency to increased efficiency and specific mechanical energy consumption was observed along with the increase of screw speed during processing. The highest production efficiency was observed if fresh leek and onion were used as additives and the highest extrusion speed screw was applied. The largest specific energy consumption was noted during the extrusion-cooking of blends containing fresh carrot and onion addition at high screw speed.
Impact of Print Speed on Strength of Samples Printed in FDM Technology
Authors: Miazio Łukasz 
Published: September 2019

Abstract
This paper presents research on the impact of printing speed on the strength of a manufactured object and is the next stage of the author's research on the impact of technological parameters of 3D printing on the strength of printed models. The tested universal specimens were printed using the FDM (Fused Deposition Modeling) method from PLA (polylactic acid, polylactide). The paper presents the maximum breaking force of the samples and the time of printing samples depending on the printing speed, which varied from 20 mm·s−1 to 100 mm·s−1. The research indicates that the strength of samples decreases with increasing speed. In the range of 50-80 mm·s−1, the strength of the specimens remined at a similar level, however, above 80 mm·s−1, it decreased significantly.
Methods for Asssessing Energy Efficiency of Grain Dryers
Authors: Nowak Janusz , Przystupa Wojciech 
Published: September 2019

Abstract
The article presents an algorithm for calculating selected energy assessment indexes for grain driers. Particular attention was paid to the conversion of the equations obtained for the operating conditions of the drying process into equations allowing the calculation of indexes for the standard drying conditions. The indexes obtained allow a proper comparison of dryers operating in varied atmospheric conditions, as well as humidity and temperature of the dried material.
Checklist of the vascular flora of Wielkopolska (Poland): casual alien species
Authors: Jackowiak Bogdan , Celka Zbigniew , Chmiel Julian , Latowski Karol , Żukowski Waldemar 
Published: September 2019

AbstractThe list of alien vascular plant species only temporarily occurring in Wielkopolska refers to the previously published list of native and permanently established plants. Together, these two lists document the vascular flora of this region at the beginning of the 21st century. The current list, like the previous one, is a result of critical analysis of both contemporary and historical data, collected since the beginning of the 19th century. All information accessible in herbarium collections, publications and unpublished materials was used. A critical analysis was conducted at the taxonomic, nomenclatural, chorological and habitat levels, based on the verification of negative information not supported by sufficient arguments. The list is presented in an alphabetical order. Information on each species includes: family affinity, life form, geographic and historic status. In cases particularly disputable, the standard characteristic of a species was supplemented with an additional commentary.
Systematic review and meta-analysis of within-subject and between-subject biological variation estimates of 20 haematological parameters
Authors: Coskun Abdurrahman , Braga Federica , Carobene Anna , Tejedor Ganduxe Xavier , Aarsand Aasne K. , Fernández-Calle Pilar , Díaz-Garzón Marco Jorge , Bartlett William , Jonker Niels , Aslan Berna , Minchinela Joana , Boned Beatriz , Gonzalez-Lao Elisabet , Marques-Garcia Fernando , Perich Carmen , Ricos Carmen , Simón Margarita , Sandberg Sverre 
Published: September 2019

AbstractBackgroundInterpretation of the complete blood count (CBC) parameters requires reliable biological variation (BV) data. The aims of this study were to appraise the quality of publications reporting BV data for CBC parameters by applying the BV Data Critical Appraisal Checklist (BIVAC) and to deliver global BV estimates based on BIVAC compliant studies.MethodsRelevant publications were identified by a systematic literature search and evaluated for their compliance with the 14 BIVAC criteria, scored as A, B, C or D, indicating decreasing compliance. Global CVIand CVGestimates with 95% CI were delivered by a meta-analysis approach using data from BIVAC compliant papers (grades A–C).ResultsIn total, 32 studies were identified; four received a BIVAC grade A, 2 B, 20 C and 6 D. Meta-analysis derived CVIand CVGestimates were generally lower or in line with those published in a historical BV database available online. Except for reticulocytes, CVIestimates of erythrocyte related parameters were below 3%, whereas platelet (except MPV and PDW) and leukocyte related parameters ranged from 5% to 15%.ConclusionsA systematic review of CBC parameters has provided updated, global estimates of CVIand CVGthat will be included in the newly published European Federation of Clinical Chemistry and Laboratory Medicine BV Database.
Variation and serial correlation of modulus of elasticity between and within European oak boards (Quercus robur and Q. petraea)
Authors: Tapia Cristóbal , Aicher Simon 
Published: September 2019

Abstract
This research aimed at describing the tensile modulus of elasticity (MOE), density and knot variability between and within oak (Quercus robur, Q. petraea) boards, which is essential for the stochastic modeling of wooden composites, such as glulam. Longitudinal deformations for 100-mm long cells were measured. The local density variation along boards revealed a very low mean coefficient of variation (COV) of 3%. The global MOE was precisely predicted from local (cell) MOEs, which span from 2.6 to 22 GPa. The mean COV of local MOE along board length was 12%, with extremes of 3% and 28%. The cell-related relationships of MOE with either density or knot area ratio showed low R-values of 0.4 and 0.3, respectively. A multivariate linear regression with both variables increased the MOE prediction to R = 0.6, which is below the literature results for beech and spruce wood. A serial correlation analysis of the local MOE was performed for board segments quasi-free of knots and for all cells, investigating different normalization approaches. Applying no MOE normalization delivered too high correlations due to pronounced inter-board MOE variations. A normalization based on an averaged maximum MOE per board delivered reasonable serial correlation results for the first four lags of the MOE knot-free variation (0.61; 0.38; 0.19 and 0.08). Considering also the knot-affected cells reduced the serial correlation roughly by a factor of 2.
Uncovering the ultrastructure of ramiform pits in the parenchyma cells of bamboo [Phyllostachys edulis (Carr.) J. Houz.]
Authors: Lian Caiping , Zhang Shuqin , Liu Xianmiao , Luo Junji , Yang Feng , Liu Rong , Fei Benhua 
Published: September 2019

Abstract
Pits are the main transverse channels of intercellular liquid transport in bamboo. Ramiform pits are a special type of simple pit with two or more branches. However, little is known about the morphology and physiological functions of ramiform pits. The anatomy of plants can provide important evidence for the role of cells. To better understand the ultrastructure and the structure-function relationship of ramiform pits, their characteristics need to be investigated. In this study, both qualitative and quantitative features of ramiform pits were studied using field-emission environmental scanning electron microscopy (FE-ESEM). The samples included the native structures and the replica structures obtained by resin castings. The results show that the ramiform pits have a diverse morphology that can be divided into main categories: type I (the primary branches) and type II (the secondary branches). The distribution of ramiform pits is different in ground parenchyma cells (GPCs) and vascular parenchyma cells (VPCs). The number, the pit aperture diameter and the pit canal length of ramiform pits in the VPCs were, respectively, greater (3-fold), larger (2–3-fold) and shorter (1.3-fold) than those in the GPCs.
Tracing local energy markets: A literature review
Authors: Mengelkamp Esther , Diesing Julius , Weinhardt Christof 
Published: September 2019

Abstract
We conduct a structured literature review on the concept of local energy markets (LEMs). LEMs have gained increasing attention in the last two decades. Yet, a holistic definition and clear demarcation of LEMs is still missing. The review shows current works to shift their focus from conceptual implementation and design to increasingly realistic applications of LEMs. Secure access to (near) real-time smart meter data is a prerequisite for LEMs. Current research gaps, e. g. the inclusion of network constraints, agent-centric LEM designs or a comparison of market mechanisms, are identified.
Comparative Analysis of Methane Concentration Near the Junction of the Longwall and Top Road
Authors: Zmarzły Marian , Trzaskalik Paweł 
Published: September 2019

Abstract
Mining of longwalls ventilated by the „U” method is willingly applied in Polish coal-mines due to low costs of workings maintenance, low costs of ventilation and a lower fire threat because of a limited flow of air through goafs. However, such a way of ventilation may pose an increased risk of methane explosion. For this reason, the “U” ventilation has been limited in longwalls with methane risk. The mining regulations in force provide that ventilation methane-bearing capacity, i.e. the intensity of methane flow into the ventilation air cannot exceed 20 m3 CH4/min. The regulations also provide that in the event the absolute methane-bearing capacity, i.e. a sum of methane released to the ventilation air and captured by the methane drainage system is higher than 25 m3 CH4/min and the “U” method of ventilation is applied, the effectiveness of methane drainage should be minimum 50% in relation to the forecast absolute methane-bearing capacity. To streamline the process of ventilation near the junction of the longwall and the gallery carrying off the used air, auxiliary ventilation means are applied, such as a ventilation partition, a ventube – which supplies air without methane or with a low concentration of methane, injectors etc. Application of these means is limited by the cross-section of the heading carrying off the air from the longwall. Deformations of the ventilating roadway, which is usually located in the one-sided vicinity of goafs, may prevent the use of a ventilation partition, which has a negative influence on the conditions of ventilating the junction of the longwall and ventilating roadway. The author of the article also refers to such conditions, presenting average values and maximum concentrations of methane concentrations recorded with four methane concentration sensors, located in the vicinity of the junction of the longwall and ventilating roadway.