bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Post-Ischemic Increase in GluA2 Ser880 Phosphorylation Involves NADPH Oxidase
Authors: Jackson Darrell A. , Astruc-Diaz Fanny , Byrnes Nicole M. , Beske Phillip H. 
Published: March 2019

Most 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid receptors (AMPARs) expressed on adult hippocampal pyramidal neurons contain the edited form of GluA2 (Q607R) and are thus impermeable to Ca2+/Zn2+ entry. Following ischemic injury, these receptors undergo a subunit composition change, switching from a GluA2-containing Ca2+/Zn2+-impermeable AMPAR to a GluA2-lacking Ca2+/Zn2+-permeable AMPAR. Recent studies indicate that an oxidative stress signaling pathway is responsible for the I/R-induced changes in AMPAR subunit composition. Studies suggest that nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase), a superoxide generator, is the source that initiates the oxidative stress-signaling cascade during post-ischemic reperfusion. The objective of the present study was to determine if suppression of NADPH oxidase activity prevents the increase in phosphorylation and subsequent internalization of the GluA2 AMPAR subunit during reperfusion of post-ischemic hippocampal slices. In this study, we demonstrated that exposure of adult rat hippocampal slices to oxygen glucose deprivation/reperfusion (OGD/R) results in an increase in Ser880 phosphorylation of the GluA2 subunit. The increase in Ser880 phosphorylation resulted in the dissociation of GluA2 from the scaffolding proteins Glutamate receptor-interacting protein 1 (GRIP1) and AMPAR binding protein (ABP), thus enabling the association of GluA2 with protein interacting with C kinase 1 (PICK1). OGD/R also resulted in an increase in the association of activated protein kinase C ? (PKC?) with PICK1. We have found that pharmacological inhibition of NADPH oxidase with apocynin diminishes the OGD/R-induced increase in activated PKC? association with PICK1 and subsequent Ser880 phosphorylation of GluA2. Suppression of NADPH oxidase activity also blunted OGD/R-induced decreased association of GluA2 with the scaffolding proteins GRIP1 and ABP. Protein phosphatase 2A (PP2A), which regulates PKC? activity by dephosphorylating the kinase, was inactivated by OGD/R-induced increase in tyrosine phosphorylation of the phosphatase (Y307). Inhibition of NADPH oxidase activity ameliorated OGD/R-induced PP2A phosphorylation and inactivation. Our findings are consistent with a model of OGD/R-induced Ser880 phosphorylation of GluA2 that implicates NADPH oxidase mediated inactivation of PP2A and sustained PKC? phosphorylation of GluA2.
Intraocular Pressure Control for Patients Undergoing Combination Intravitreal Anti-VEGF and Dexamethasone Therapy for Macular Edema from Retinal Vein Occlusion
Authors: Singer Michael , Bell Darren , Singer Joshua , Woods Paul , Jergensen Tyson R. , Yanev Petar G. , Iltis Joshua M. , Tyler Lyndon D. , Beck Kinley D. 
Published: March 2019

Background and Objective: Sustained-release dexamethasone intravitreal implant is an effective treatment for macular edema secondary to retinal vein occlusion (RVO) but ocular hypertension is a side effect. This study evaluated whether the addition of a single combination IOP-lowering medication will reliably control intraocular pressure (IOP) for those patients. Study Design/Patients and Methods: Retrospective chart review of 62 patients that underwent multiple injections of combination anti-VEGF and sustained-release dexamethasone intravitreal implant for macular edema secondary to RVO. IOP spikes were treated with brimonidine 0.2% - timolol 0.5%. IRB approval was obtained. Results: The average elevated IOP requiring treatment was 28.6 mmHg. The average IOP after adding brimonidine 0.2% - timolol 0.5% was 16.7 mmHg. 100 percent of treatment cycles had an IOP< 30 mmHg after starting treatment. Conclusions: Using one combination IOP-lowering drop can reliably control the ocular hypertension that occurs secondary to combination therapy for macular edema in RVO.
Curadoria Digital de dados e Web de Dados: mantendo Dados Abertos Conectados para estudos bibliométricos e cientométricos
Authors: Rautenberg Sandro , Hild Tony Alexander , De Souza Lucélia 
Published: March 2019

Discorre sobre os primeiros passos em direção à Curadoria Digital de índices cientométricos como Dados Abertos Conectados na Web de Dados. Por se tratar de um relato de experiência, com sua base constitutiva permeando a interdisciplinaridade, o procedimento metodológico é baseado nos ciclos de vida da Curadoria Digital proposto pelo Digital Curation Centre e do Linked Data Lifecycle proposto pelo grupo de pesquisa Agile Knowledge Engineering and Semantic. Como resultado, implementa-se o endpoint <http://lod.unicentro.br>, custodiando os recursos de dados do histórico de três índices cientométricos (Qualis, SJR e SNIP, no período 2005-2016). Diante disso, os referidos índices estão disponibilizados na Web de Dados, privilegiando o acesso, o reuso, a interoperabilidade e a processabilidade de seus recursos para com outras pesquisas bibliométricas/cientométricas. Conclui-se que, ao custodiar três conjuntos de índices cientométricos como Dados Abertos Conectados, o endpoint <http://lod.unicentro.br> permite: i) a encontrabilidade dos recursos na Web de Dados; ii) a navegabilidade entre os elementos distribuídos na web; iii) a exploração informacional do relacionamento entre os recursos disponibilizados; e iv) a replicação de resultados em estudos científicos ao longo do tempo.
STUDENTS’ PERCEPTION ON THE IMPLEMENTATION OF ISLAMIC SCIENCE INTEGRATION IN ENGLISH TEACHING MATERIALS
Authors: Uswatun Hasanah, Mufidatunnisa 
Published: March 2019

Integration of Islamic science in English language learning for Muslim students is a necessity that should be realized by every teacher, especially in developing teaching materials that are applied in the classroom. This study aims at finding out the perception of STAIN Watampone students particularly Islamic Education program that have taught English by using integrated Islamic science material. Using interviews, it was revealed that the students give positive attitudes toward the implementation of Islamic science into teaching English material. The result shows that the use of integrated English and Islamic material can produce a lot of interest and a make learning activities more effective and efficient. This gives an indication that the teacher or the stake holder can formulate the integrated teaching materials to suit the needs and interests of students.

Keywords: Integration, Islamic science, Teaching material
Finite volume method for a coupled Stokes-Darcy problem
Authors: Rhoudaf M. , StaÃrli Naoufal 
Published: March 2019

In this paper we propose a finite volume method to solve the coupled Stokes-Darcy problem using steady Stokes equations for the fluid region and Darcy equations for the porous region.
At the contact interface between the fluid region and the porous media we imposed two conditions. The first one is the normal continuity of the velocity, while the second one is the continuity of the pressure. Furthermore, due to the lack of information about both the velocity and the pressure on the interface, we will use schwarz domain decomposition method. In Darcy equations, the tensor of permeability will be considered as variable, since it depends on both the prop- erties of the porous medium and the viscosity of the fluid. Numerical examples are presented to demonstrate the efficiency of the proposed method
Randomised controlled trial of the short-term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention-deficit/hyperactivity disorder (CIAO-II)
Authors: Asherson Philip , Johansson Lena , Holland Rachel , Fahy Thomas , Forester Andrew , Howitt Sheila , Lawrie Stephen , Young Susan , Landau Sabine , Thomson Lindsay 
Published: March 2019

Abstract
Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalence disorder, seen in 20-30% of young adult prisoners. Pharmacoepidemiological studies, a small randomised controlled, and open trial data suggest clinically significant reductions in ADHD symptoms, emotional dysregulation, disruptive behaviour and engagement with educational activities. Yet, routine treatment of ADHD in offenders with ADHD is not yet established clinical practice. There is continued uncertainty about the clinical response to methylphenidate, a first line treatment for ADHD, in offenders who often present with an array of complex mental health problems that may better explain states of inattentive, overactive restless and impulsive behaviours. To address this problem we conduct an efficacy trial to establish the short term effects of OROS-methylphenidate (Concerta XL), an extended release formulation of MPH, on ADHD symptoms, emotional dysregulation and behaviour.
Methods: Parallel arm randomised placebo-controlled trial of OROS-MPH on ADHD symptoms, behaviour and functional outcomes in young male prisoners aged 16-25, meeting DSM-5 criteria for ADHD. Participants are randomised to 8-weeks treatment with OROS-MPH or placebo, titrated over 5 weeks to balance ADHD symptom improvement against side effects. 200 participants will be recruited with 1:1 ratio of drug to placebo. The primary outcome is change in level of ADHD symptoms after 8-weeks of trial medication.
Discussion: Potential benefits include improvement in ADHD symptoms, emotional dysregulation, attitudes towards violence, critical incidents and engagement with educational and rehabilitation programs. Demonstrating efficacy and safety of MPH on ADHD symptoms and associated impairments may provide the data needed to develop effective healthcare pathways for a significant group of young offenders. Establishing efficacy of MPH in this population will provide the foundation needed to establish long term effectiveness studies with the potential for demonstrating significant reductions in criminal behaviour and improved health-economic outcomes.
Trial Registration: ISRCTN16827947l; EudraCT Number: 2015-004271-78.
Protocol version: v2.0 30.08.2018
The Nature stroke study; NASTRU - A randomised controlled trial of nature-based post-stroke fatigue rehabilitation
Authors: Pálsdóttir Anna María , Stigmar Kjerstin , Norrving Bo , Grahn Patrik , Petersson Ingemar F , Åström Mikael , Pessah-Rasmussen Hélène 
Published: March 2019

Abstract
Fatigue is common after stroke and contributes to disability and impaired quality of life. Currently, there is insufficient evidence on the efficacy of any intervention for post-stroke fatigue.
The aim of the study was to examine whether 10 weeks Nature-based rehabilitation (NRB) as add-on to standard care may improve post-stroke fatigue, perceived value of everyday occupations, function, activity and participation compared to standard care only (Clinical Trial.gov Identifier: NCT02435043, 2012/352, 05-06-2015).
The study was carried out as a single blinded two-armed randomised controlled trial. Stroke survivors identified through routine 3-month follow-up visit (sub-acute) or medical records (chronic stroke > 1 year earlier) were randomised to Standard care + NBR or Standard care only. Blinded evaluations were conducted at follow-up 8 and 14 months after randomisation.
The primary outcomes were post-stroke fatigue (Mental Fatigue Scale, total score) and perceived value of everyday occupations (Oval-pd) 8 months after randomisation. About a quarter of the screened patients were eligible; half accepted to participate and 101 were randomised, mean age 67 years, 60% female. The patients with sub-acute stroke were highly compliant with the intervention. Fatigue decreased to a value below the suggested cut-off for mental fatigue (<10.5) in the intervention group but not in the control group; no statistically significant differences were found though between the groups.
Conclusion: NASTRU is the first randomised study on NBR for patients with post stroke fatigue. NBR was feasible and well tolerated. The study was underpowered due to difficulties in recruiting participants. No significant differences were detected between intervention and control group. A larger RCT is warranted.

Keywords: clinical trial, enriched environment, everyday occupations, horticulture therapy, quality of life.
Późne działania niepożądane uzupełniającego leczenia systemowego u chorych z rozpoznaniem raka piersi.
Authors: Myśliwiec Paulina 
Published: March 2019

W ostatnich latach znacząco poprawiły się wyniki leczenia raka piersi. W dużej mierze związane jest to ze stosowaniem uzupełniającego leczenia systemowego.Optymalna chemioterapia i immunoterapia oraz kompleksowa hormonoterapia przyczyniły się do wydłużenia czasu przeżycia całkowitego i czasu wolnego od choroby, jednak leczenie nieuchronnie wiąże się z występowaniem działań niepożądanych, które mogą wpływać na jakość życia chorych. Wczesne działania niepożądane leczenia systemowego ustępują maksymalnie do 6 miesięcy od zakończenia terapii. Późne objawy uboczne mogą utrzymywać się do końca życia pacjentów, a metody ich leczenia są często niesatysfakcjonujące.
Pomiary rozkładów dawek poza obszarem terapeutycznym na wybranych głębokościach i odległościach od osi wiązki.
Authors: Kowalik Anna 
Published: March 2019

Celem pracy było zbadanie dawek poza obszarem terapeutycznym na wybranych głębokościach i odległościach od osi wiązki (CAX). Na potrzeby badania zaprojektowano i skonstruowano fantom wodny o wymiarach 45cm x 35cm x 90cm, w którym umieszczone zostały detektory termoluminescencyjne (TLD 100). Detektory umieszczone zostały na czterech głębokościach : 2cm, 5cm, 8cm, i 15 cm oraz czterech odległościach (dla każdej głębkości) od osi wiązki: 10, 20, 30 i 40 cm. W osi wiązki zadano dawkę 76 Gy, co odpowiadało 7503 jednostkom monitorowym (MU). Dawka w odległości 10 cm od osi wiązki i 2 cm głębokości była bliska dawce na głębokości 15 cm i wynosiła średnio 2,3 Gy. Pomiary dawek pokazały silną zależność dawki w zależności od odległości od osi wiązki. Dla dystansu 40 cm od CAX na głębokości 2 cm, zmierzono dawkę równą 0,27 Gy (SD= 0,025), na 15cm od CAX 0,116 (SD=0,066). W odległości 30 cm od osi wiązki zależność dawki wraz z głębokością była znacząca na głębokości 2 cm – 0.524 Gy (SD=0,251) oraz na głębokości 15 cm – 0.242 Gy (SD=0,564). 20 cm od osi wiązki na 2 cm głębokości wynosiła 0,925 Gy (SD=0,483) i głębokości 15 cm 0,517 (SD=0,160)
Detoxification of Heterocyclic Aromatic Amines by Probiotic to Inhibit Medical Hazards
Authors: Khosravi-Darani Kianoush , Barzegar F. , Baghdadi M. 
Published: March 2019

:
Cancer is the second leading factor of human death in the world. Long-term consumption of
cooked red meat brings about various types of cancers like colorectal cancer due to the formation of
Heterocyclic Aromatic Amines (HAAs) during the heating process of meat. There are various solutions
for the reduction of these toxicants. The aim of this article is to describe probiotic as one of the possible
strategies for bioremoval of these carcinogenic and mutagenic substances and change food to functional
one as well. The mechanism of biodetoxification is binding by probiotics, which depends on
some variables including the probiotic characteristics, kind and content of the mutagens, as well as
some properties of media. In this article, after introducing detoxification ability of probiotics and listing
of all reported probiotics in this field, the influencing variables are surveyed and finally, opportunities
and problems of HAA bioremoval by probiotics are described.
Dietary Adherence, Self-Efficacy, and Health Behavior Change of WASHOKU-Modified DASH Diet: A Sub-analysis of the DASH-JUMP Study
Authors: Kawamura Atsuko , Inagaki Junko , Umemoto Seiji , Kajiya Katsuko , Kishi Hiroko , Mitarai Makoto , Oda Hiroshi , Kobayashi Sei 
Published: March 2019

Background:
We previously reported the nutritional characteristics and effects of the
DASH-JUMP diet, which is a WASHOKU-modified DASH diet, in Japanese participants with
untreated high-normal blood pressure or stage 1 hypertension. The dietary adherence of the DASH
diet in Japanese participants has never been evaluated before.

Objective:
We aimed to assess the relationships between dietary adherence, self-efficacy, and health
behavior change among study participants who received the DASH-JUMP diet by home delivery.

Methods:
Participants were treated with the DASH-JUMP diet for 2 months and consumed their
usual diets for the next 4 months. We conducted surveys using the stage of behavior change model
questionnaire and the modified perceived health competence scale Japanese version questionnaire at
baseline and 1, 2, 3, and 6 months to assess dietary adherence.

Results:
Forty-three participants (25 men, 18 women; mean age 53.6 ± 8.2 years) returned completed
questionnaires, which we analyzed. Health behavior change was motivated by previous behavioral
changes and improved biomarkers. The improvement and maintenance of self-efficacy
were deeply related to health behavior change and previous self-efficacy. The experience of the
DASH-JUMP study for participants included three processes to improve lifestyle habits: Phase 1,
reflecting on previous lifestyle habits; Phase 2, learning through new experiences and the acquisition
of knowledge; and Phase 3, desiring to maintain their own health.

Conclusion:
It indicated that the DASH-JUMP diet significantly increased self-efficacy and promoted
health behavior change.
Modification in the Natural Bioactive Molecule: Piperine; A Continuing Source for the Drug Development
Authors: Chopra Bhawna , Dhingra Ashwani K. , Prasad Deo N. 
Published: March 2019

Background:
Piperine, a bioactive alkaloid was a well-known component which was used
traditionally to treat a variety of disorders.

Objective:
The present review is to discuss the modified piperine or piperic acid analogs or its derivatives
to explore the potential of piperine. Piperine or piperic acid had potentials as antibacterial, antitumor,
antioxidant, anti-inflammatory, antifungal, immunomodulatory and many more for drug development.
So modification in natural molecule piperine generates numerous derivatives or analogues which
may be found beneficial in drug development.

Methods:
A literature survey has been carried out to determine the real potential of piperine and its
modified analogs.

Results:
It has been scrutinized that piperine and its derivatives possess valuable components with good
therapeutic potential.

Conclusion:
Thus, this review aims to provide knowledge as well as to explore the excellent potential
of piperine, piperic acid, piperine derived compounds/ analogs which may further, after performing
toxicity studies, and other parameters, be helpful in the design and development of novel drug candidates
against numerous disease conditions and thus it paves way for further work in exploring the potential
to treat the patients with obesity and skin related disorders.
Design, Synthesis, Anti-Proliferative, Anti-microbial, Anti-Angiogenic Activity and In Silico Analysis of Novel Hydrazone Derivatives
Authors: Ünver Hakan , Berber Burak , Demirel Rasime , Koparal Ayşe T. 
Published: March 2019

Background:
Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives
have high activity, and for this reason, these compound are greatly used by researchers to synthesize new
anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents.

Methods:
New hydrazone derivatives were synthesized via a reaction between 3-formylphenyl methyl carbonate
and benzhydrazide, 4-methylbenzoic hydrazide, 4-tert-butylbenzoic hydrazide, 4-nitrobenzoic hydrazide and 3-
methoxybenzoic hydrazide, and were successfully characterized using elemental analysis, 1H-NMR, 13C-NMR,
FT-IR and LC-MS techniques. The synthesized compounds were evaluated for their antimicrobial (some grampositive
and -negative bacteria, filamentous fungi and yeasts), anti-proliferative (T47D and HCC1428-breast
cancer cells) and anti-angiogenic (HUVEC-endothelial cells) activities. The anti-proliferative activities of the
hydrazone compounds R1-R5 were studied on these cell lines by MTT assay. The anti-angiogenic potential of
the compounds was determined by the endothelial tube formation assay. To identify structural features related to
the anti-proliferative activity of these compounds, 2D-QSAR was performed.

Results:
The results indicated that compound R3 exhibited strong anti-angiogenic and anti-proliferative activity
on breast cancer cell lines and healthy cell lines. Also, this compound; possessing a tertiary butyl moiety on the
hydrazine, exhibited the highest inhibitory effect against all tested microorganisms; in particular, it inhibited
Candida albicans at a lower concentration than ketoconazole. Among the investigated compounds, those bearing
methyl, tertiary butyl (compound R2, R3) and methoxy (compound R5) moiety were found to be more
successful anticandidal derivatives than standard antifungal antibiotics. The QSAR analysis suggested that the
tumor specificity of the hydrazone correlated with their molecular weight, lipophilicity, molar refractivity, water
solubility, DipolHybrid:(MOPAC) and ExchangeEnergy:(MOPAC). Absorption, Distribution, Metabolism and
Elimination (ADME) analysis of the hydrazone compounds showed that they have favorable pharmacokinetic
and drug-likeness properties. The ADME results clarify that R3 is the best compound in terms of pharmacokinetic
properties. In contrast to other compounds; target prediction analysis of the compound R3 showed inhibitory
activity on estrogen-related receptor alpha transcription factor (ESRRA). The target prediction analysis was
supported by molinspiration bioactivity score.

Conclusion:
The R3 compound is considered to be an important candidate for future studies with its suitability
for the Lipinski’s rule of five for drug-likeness, and effective in vitro and in silico results.
Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools
Authors: Gano Lurdes , Pinheiro Teresa , Matos António P. , Tortosa Francisco , Jorge Tiago F. , Gonçalves Maria S. , Martins Marta , Morais Tânia S. , Valente Andreia , Tomaz Ana I. , Garcia Maria H. , Marques Fernanda 
Published: March 2019

Background:Ruthenium complexes have been extensively investigated for their prospective value as alternatives to cisplatin. Recently, we reported the in vitro anticancer properties of a family of organometallic ruthenium( II)-cyclopentadienyl complexes and have explored their mechanism of action.Objective:The purpose of this study was to evaluate the in vivo antitumour efficacy and toxicity of one of these Ru(II) compounds, [RuCp(mTPPMSNa)(2,2′-bipy)][CF3SO2] (TM85) which displayed an interesting spectrum of activity against several cancer cells.Methods:Studies to assess the antitumour activity and toxicity were performed in a metastatic prostate (PC3) mice model using ICP-MS, nuclear microscopy, elemental analysis and Transmission Electron Microscopy (TEM).Results:TM85 showed low systemic toxicity but no significant tumour reduction, when administered at tolerated dose (20mg/kg) over 10 days. Ru was mainly retained in the liver and less in kidneys, with low accumulation in tumour. Increased bilirubin levels, anomalous Ca and Fe concentrations in liver and mitochondria alterations were indicative of liver injury. The hepatotoxicity observed was less severe than that of cisplatin and no nephrotoxicity was found.Conclusion:Under the experimental conditions of this study, TM85 is less toxic than cisplatin, induces similar tumour reduction and avoids the formation of metastatic foci. No renal toxicity was observed by the analysis of creatinine levels and the effective renal plasma flow by 99mTc-MAG3 clearance. Hence, it can be considered a valuable compound for further studies in the field of Ru-based anticancer drugs.