bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Orthodontic Treatment With Straight-Wire Appliance on the Incidence of Temporomandibular Disorders—A 3-Year Cohort Study
Authors: Jeelani Waqar , Habib Amna , Ali Batool , Ahmed Maheen 
Published: September 2019

Introduction: A change in occlusion during orthodontic treatment can affect muscles and joints surrounding the jaw, resulting in temporomandibular disorders (TMD). The aim of this study was to determine the effect of orthodontic treatment with straight-wire appliance on the incidence of TMD in young adults. Materials and Methods: A cohort study was carried out involving 177 adult patients (91 in the treatment group and 86 in the control group). Fonseca’s questionnaire was used for TMD evaluation for all patients at the time of obtaining orthodontic pretreatment records (T0). TMD assessment was repeated after an average of 3 years of initial assessment for both the treatment and control groups (T1). Results: The number of patients with TMD changed significantly ( P < .001) from T0 to T1 in both groups. The prevalence of TMD increased from 36.3% to 41.8% in the treatment group and decreased from 46.5% to 38.4% in the control group after 3 years. The relative risk of developing TMD after orthodontic treatment was 1.16, whereas the odds of TMD resolution after orthodontic treatment was 0.73, both of which were statistically nonsignificant ( P > .05). Conclusion: Orthodontic treatment with noncustomized straight-wire appliance has nonsignificant effects on the incidence of TMD in young adults.
A Retrospective Review of Angiotensin II Use in Adult Patients With Refractory Distributive Shock
Authors: Wong Adrian , Alkazemi Afrah , Eche I. Mary , Petri Camille R. , Sarge Todd , Cocchi Michael N. 
Published: September 2019

Purpose: Catecholamines are first-line vasopressors for hemodynamic support in distributive shock but are associated with adverse effects, which may be mitigated with noncatecholamine vasopressors. Angiotensin II (ATII) is a noncatecholamine vasopressor recently approved for the management of distributive shock, but limited data support its clinical utility. The purpose of this study was to describe our institution’s usage of ATII including patient outcomes (eg, response to therapy, safety profile). Materials and Methods: Patients who received ATII at our institution were included. Patient demographics, degree of concordance with institutional ATII use guidelines, safety profile of ATII, and response to therapy (1 and 3 hours after ATII initiation) were collected. Results: A total of 16 patients received ATII for distributive shock. The median Sequential Organ Failure Assessment score at the time of ATII initiation was 16.5 (interquartile range: 15.8-20.0). Fourteen (87.5%) patients met institutional guidelines for ATII use; 10 (62.5%) and 8 (50.0%) patients met our definition for response at 1 and 3 hours, respectively. No patients developed thrombotic or infectious complications after receiving ATII. Conclusions: In this cohort, ATII appears to be well tolerated in patients with a high predicted mortality. Future studies evaluating the clinical efficacy of ATII are needed to determine its role in the management of distributive shock.
Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study
Authors: Liang Yan , Chen Yang-Kun , Liu Yong-Lin , Mok Vincent C. T. , Ungvari Gabor S. , Chu Winnie C. W. , Seo Sang Won , Tang Wai-Kwong 
Published: September 2019

Objective: This study investigated the association between small vessel disease (SVD) burden, a combination of multiple SVD markers and cognitive dysfunction after stroke. Methods: The study sample comprised 451 patients with first-ever acute ischemic stroke. Cognitive functions were assessed with the Mini-Mental State Examination (MMSE) at 3, 9, and 15 months after the index stroke. Cognitive impairment was defined as an MMSE score of ≤26. A total SVD score, indicating SVD burden, was constructed by summing the scores of the 4 SVD markers (white matter hyperintensities [WMHs], lacunes, cerebral microbleeds, and perivascular spaces) ascertained by magnetic resonance imaging (range: 0-4). The association between SVD burden and cognitive dysfunction was assessed with linear mixed models or generalized estimating equation models, as appropriate. Results: The majority of patients had mild-to-moderate stroke and at least one identifiable SVD marker. Cognitive impairment was found in about one-third of patients. After adjusting for confounding factors, the SVD burden was associated with MMSE scores (β = −0.37, P = .003) and cognitive impairment (odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.02-1.42). SVD burden was specifically associated with the performance of MMSE subscores including orientation to place and time, calculation, and word recall. Of the SVD markers, WMHs was the most robust predictor of decrease in MMSE scores (β = −0.25, P = .01) and cognitive impairment (OR = 1.14, 95% CI = 1.01-1.29). Conclusion: Cerebral SVD burden is associated with decreased MMSE scores, suggesting cognitive dysfunction during the first year after mild-to-moderate acute ischemic stroke.
Asiasiga: a Samoan intervention to address the immediate mental health needs of Samoan communities after a tsunami
Authors: Tamasese Taimalieutu Kiwi , Parsons Tafaoimalo Loudeen , Waldegrave Charles , Sawrey Richard , Bush Allister 
Published: September 2019

Objective: To describe an Indigenous Samoan psychosocial intervention developed to address the mental health needs of affected communities in Samoa following a tsunami. Method: A partnership was established between Samoan therapists, Samoan Catholic pastoral workers and non-Samoan mental health clinicians, informed by Samoan concepts of self and wellbeing. The format developed for visits to significantly affected households was based on a Samoan cultural practice known as asiasiga and was carried out by pastoral workers, with daily group supervision and access to mental health professionals. Results: Household visits were offered to affected families in villages throughout southern and eastern Upolu and the island of Manono. There was a high degree of acceptance of the programme by Pulenu’u (village governance leaders) and family leaders and members. Conclusions: Mental health responses to the needs of Indigenous Pacific communities following a disaster need to be embedded in the values of those communities. The Samoan practice of asiasiga contributed to the high degree of acceptability of this programme. Partnerships with churches, schools and other local organisations are likely to enhance acceptability and participation. More research is required on Indigenous Pacific post-disaster mental health programmes.
Comparison of signalment, clinical, laboratory and radiographic parameters in cats with feline asthma and chronic bronchitis
Authors: Grotheer Maike , Hirschberger Johannes , Hartmann Katrin , Castelletti Noemi , Schulz Bianka 
Published: September 2019

Objectives Feline asthma (FA) and feline chronic bronchitis (CB) are common respiratory conditions in cats, frequently referred to as ‘feline lower airway disease’. However, the aetiologies of both inflammatory airway diseases are probably different. Little is known about the differences in signalment, clinical signs, laboratory abnormalities and radiographic features between cats with these two airway diseases. The aim of the study was to investigate whether certain parameters can help in differentiating between both diseases, as distinguished by airway cytology. Methods Seventy-three cats with FA and 24 cats with CB were included in the retrospective study. Inclusion criteria were compatible clinical signs and a cytological evaluation of bronchoalveolar lavage fluid indicating either FA (eosinophilic inflammation) or CB (neutrophilic inflammation) without cytological or microbiological evidence of bacterial infection. Parameters of signalment, physical examination, haematology and thoracic radiographs of both disease groups were compared statistically ( P <0.05). Results The median age of cats with FA was 6 years, and was 7.5 years in cats with CB ( P = 0.640). The most commonly reported clinical signs in both groups were a cough (95% FA/96% CB; P = 1.000), pathological pulmonary auscultatory sounds (82% FA/79% CB; P = 0.766) and dyspnoea (73% FA/79% CB; P = 0.601). Abnormal radiographic lung patterns were detected in 94% of cats with FA and 91% with CB ( P = 0.629), respectively. Blood eosinophilia was significantly more common in cats with FA (40%) compared with CB (27%) ( P = 0.026). Conclusions and relevance The study indicates that a differentiation of FA and CB by means of signalment, a single clinical sign, and haematological and radiographic findings is not possible.
Smartphone-assisted technique in total hip arthroplasty can improve the precision of acetabular cup placement: a randomised controlled trial
Authors: Pongkunakorn Anuwat , Diewwattanawiwat Kittipong , Chatmaitri Swist 
Published: September 2019

Background: Malposition of the acetabular component mainly results from intraoperative pelvic motion and manual errors during cup placement. We investigated the outcomes of a device that uses a level indicator application of a smartphone to function as a pelvic tilt goniometer to assess intraoperative motion. The cup positions outside Lewinnek’s safe zone were compared between the smartphone-assisted technique and the conventional method that uses a mechanical alignment guide. Methods: A randomised controlled trial was conducted among 64 patients receiving primary cementless total hip arthroplasties (THAs) via a posterolateral approach from June 2015 to February 2017. Acetabular components were implanted either by conventional technique ( n = 32) or using smartphone technique ( n = 32). Inclination and anteversion angles were measured in supine pelvic radiographs. Results: The inclination angle in the smartphone group was not significantly different from the conventional group (41.2° ± 3.9° vs. 40.3° ± 7.9°, p = 0.567). The anteversion angle was also similar (19.3 ± 3.8° vs 19.1° ± 5.9°, p = 0.856). However, the standard deviation of the angle in the smartphone group was significantly lower for inclination ( p < 0.001) and anteversion ( p = 0.016). There were 3 outliers (9.4%) in the smartphone group, but 13 (40.6%) in the conventional group ( p = 0.008). The risk ratio was 0.23 (95% CI, 0.07–0.73). The risk difference was −0.31 (95% CI, –0.51– –0.11). Conclusion: The smartphone-assisted technique in THA improves the precision of cup placement and decreases the percentage of safe zone outliers. Thai Clinical Trials Registry (ID: TCTR20151123002).
Head injury alert: A new level of trauma activation?
Authors: Ricaurte Daniel , Slack Daniel , Gilson Aaron , Nowicki Michael , Nelson Monika , Feinn Richard , Zdankiewicz Peter 
Published: September 2019

Introduction Trauma activation requires mobilization of significant resources to be available at short notice. In 2014, the American College of Surgeons Committee on Trauma issued its latest recommendations for care of the injured patient. Amongst trauma activation criteria, elderly patients that fell from any height on anticoagulation were included. We hypothesized that a reduced trauma team could preserve patient safety while reducing time and cost spent. Method A ‘Head Injury Alert’ was created to denote anti-coagulated patients with a GCS > 14 who fell from a height of <20 feet. An ED attending, surgical resident and one nurse evaluate the patient with the goal of obtaining a head CT within 30 min of presentation. Data were prospectively acquired from June 2017 to August 2018, which included age, anticoagulation, injury severity score (ISS), time-to-CT, outcomes, missed injuries, disposition and activations requiring escalation of care. Results Two hundred and seventy-seven head injury activations occurred; 55% of patients were female, while 45% were male. Average age was 78 years old. The most common anticoagulant was Warfarin (31%). 50% of patients were discharged, 47% were admitted, 2% died before disposition and 1% were transferred to a tertiary care center; 7% required admission to the ICU. The average time-to-CT was 25 min and ISS ranged from 0 to 26. Twenty-two patients (7%) presented with positive head CT. Of the five deaths, three patients had intracranial hemorrhage, one pneumonia present on admission and one cardiac arrest. Conclusion This level III evidence, prospective study suggests head injury alert can be safely applied as a new level of trauma activation at community hospitals. It helps identify a specific patient population and injury mechanism that can be safely triaged using limited resources. With this, community hospitals can maximize their resources and minimize cost, while maintaining patient safety.
The effects of a standardized nursing intervention model on immobile patients with stroke: a multicenter study in China
Authors: Liu Hongpeng , Zhu Dawei , Cao Jing , Jiao Jing , Song Baoyun , Jin Jingfen , Liu Yilan , Wen Xianxiu , Cheng Shouzhen , Nicholas Stephen , Wu Xinjuan 
Published: September 2019

Background: Immobility complications, including pressure injuries (PIs), deep vein thrombosis (DVT), pneumonia, and urinary tract infections (UTIs), affect the clinical outcomes of stroke patients. A standardized nursing intervention model (SNIM) was constructed and implemented to improve the quality of care and clinical outcomes among immobile patients with stroke. Aims: To assess the benefit of SNIM for immobility complication rates, including PIs, DVT, pneumonia, and UTIs, and mortalities in immobile patients with stroke. Methods: A before and after study design was used. Patients were divided into a pre- and post-SNIM training original cohort and matched for socioeconomic, demographic, and disease characteristics using propensity score. We fitted logistic regression models to examine the effect of SNIM, and whether the benefit differed between tertiary and non-tertiary hospitals. Results: In the original cohort, the rate of pneumonia, UTIs, and mortality was lower after SNIM training. Furthermore, in the matched cohort, the difference in PI rates was significant. Logistic regression analysis revealed that the probability of PIs, pneumonia, UTIs, and mortality were significantly reduced after SNIM training in the original cohort and this estimated value changed little in the matched cohort. Our results show that the decreased rates of pneumonia, UTIs, and mortality were mainly among non-tertiary hospitals. Conclusions: A structured and systematic SNIM benefited immobile stroke patients’ clinical outcomes, but mainly in non-tertiary hospitals in China. Standardized nursing training is needed in non-tertiary hospitals.
The Spectrinome: The Interactome of a Scaffold Protein Creating Nuclear and Cytoplasmic Connectivity and Function
Authors: Goodman Steven R. , Johnson Daniel , Youngentob Steven L. , Kakhniashvili David 
Published: September 2019

We provide a review of Spectrin isoform function in the cytoplasm, the nucleus, the cell surface, and in intracellular signaling. We then discuss the importance of Spectrin’s E2/E3 chimeric ubiquitin conjugating and ligating activity in maintaining cellular homeostasis. Finally we present spectrin isoform subunit specific human diseases. We have created the Spectrinome, from the Human Proteome, Human Reactome and Human Atlas data and demonstrated how it can be a useful tool in visualizing and understanding spectrins myriad of cellular functions.Impact statementSpectrin was for the first 12 years after its discovery thought to be found only in erythrocytes. In 1981, Goodman and colleagues1found that spectrin-like molecules were ubiquitously found in non-erythroid cells leading to a great multitude of publications over the next thirty eight years. The discovery of multiple spectrin isoforms found associated with every cellular compartment, and representing 2-3% of cellular protein, has brought us to today’s understanding that spectrin is a scaffolding protein, with its own E2/E3 chimeric ubiquitin conjugating ligating activity that is involved in virtually every cellular function. We cover the history, localized functions of spectrin isoforms, human diseases caused by mutations, and provide the spectrinome: a useful tool for understanding the myriad of functions for one of the most important proteins in all eukaryotic cells.
Containing a measles outbreak in Minnesota, 2017: methods and challenges
Authors: Banerjee E , Griffith J , Kenyon C , Christianson B , Strain A , Martin K , McMahon M , Bagstad E , Laine E , Hardy K , Grilli G , Walters J , Dunn D , Roddy M , Ehresmann K 
Published: September 2019

Aims: We report on a measles outbreak largely occurring in Minnesota’s under-vaccinated Somali community in the spring of 2017. The outbreak was already into its third generation when the first two cases were confirmed, and rapid public health actions were needed. The aim of our response was to quickly end transmission and contain the outbreak. Methods: The state public health department performed laboratory testing on suspect cases and activated an Incident Command staffed by subject matter experts that was operational within 2 h of case confirmation. Epidemiologic interviews identified exposures in settings where risk of transmission was high, that is, healthcare, childcare, and school settings. Vaccination status of exposed persons was assessed, and postexposure prophylaxis (PEP) was offered, if applicable. Exposed persons who did not receive PEP were excluded from childcare centers or schools for 21 days. An accelerated statewide measles, mumps, and rubella (MMR) recommendation was made for Somali Minnesota children and children in affected outbreak counties. Partnerships with the Somali Minnesota community were deepened, building off outreach work done with the community since 2008. Results: Public health identified 75 measles cases from 30 March to 25 August 2017: 43% were female, 81% Somali Minnesotan, 91% unvaccinated, and 28% hospitalized. The median age of cases was 2 years (range: 3 months–57 years). Most transmission (78%) occurred in childcare centers and households. A secondary attack rate of 91% was calculated for unvaccinated household contacts. Over 51,000 doses of MMR were administered during the outbreak above expected baseline. At least 8490 individuals were exposed to measles; 155 individuals received PEP; and over 500 persons were excluded from childcare and school. State and key public health partners spent an estimated $2.3 million on response. Conclusion: This outbreak demonstrates the necessity of immediate, targeted disease control actions and strong public health, healthcare, and community partnerships to end a measles outbreak.
Microwave Ablation for the Removal of Benign Lesion of Nasal Cavity: “How I Do It”
Authors: Lou Zheng-cai 
Published: September 2019

Background Isolated benign lesions of the nasal cavity are commonly seen in the rhinology clinic; their treatment using various therapies has been explored in several studies. Methods In this retrospective study, isolated lesions of the nasal cavity were removed from 47 patients using microwave ablation (MWA) with a 2450-MHz cooled MWA antenna and sent for histological examination. Results The most commonly involved site was the nasal septum (n = 21, 44.7%), followed by the inferior turbinate (n = 12, 25.5%), bulla ethmoidalis (n = 9, 19.1%), and uncinate process (n = 5, 10.6%). The most common pathology was hemangioma (n = 36, 76.6%), followed by nasal polyp (n = 9, 19.1%) and squamous papilloma (n = 2, 4.3%). All lesions were removed endoscopically using MWA in patients administered local anesthesia. The total duration of ablation was 5 to 10 minutes, with an average duration of 7.3 ± 2.6 minutes. Follow-up at 6 months revealed no severe complications, including no cases of recurrent epistaxis, septal perforation, or synechiae of the nasal cavity. Conclusions The advantages of MWA are its short ablation time and minimal complications. This was demonstrated in our study in which a single session of MWA was sufficient to excise the isolated lesion while providing hemostasis. Most of the patients well tolerated the procedure, which could be performed using local anesthesia in the outpatient setting.
Transvaginal uterine evisceration during labor in a Bengal queen
Authors: Freire Mila , Diaw Mouhamadou 
Published: September 2019

Case summary A 2.5-year-old Bengal queen was admitted with a 12-h history of a mass protruding from the vulva during labor. At that time, three healthy kittens had already been delivered. Physical examination identified the mass as a portion of the uterus that was eviscerated without eversion of the mucosa. Exploratory laparotomy revealed a vaginal vault rupture with a large portion of the uterus herniated through the tear and eviscerated through the vulva. Ovariohysterectomy was performed, and a dead fetus was removed with the uterus. Reconstruction of the vaginal rupture required careful dissection and urethral catheterization. The queen recovered without complications. Relevance and novel information Uterine evisceration through a vaginal tear is a very rare condition that sometimes is erroneously referred to as ‘prolapse’. Uterine prolapse and uterine evisceration may have similar presenting signs; however, proper identification and surgical correction is key when the uterus is eviscerated. This case highlights the importance of differentiating these two conditions and of rapid identification and surgical intervention for successful patient survival.
Cilioretinal Artery Occlusion Associated With Optic Disc Edema
Authors: Weinlander Eric , Wubben Thomas J. , Thomas Merina , Cornblath Wayne , Johnson Mark W. 
Published: September 2019

Purpose: This work investigates the clinical features of cilioretinal artery occlusion (CLRAO) in the setting of optic disc edema. Methods: A retrospective chart review of 3 patients with concomitant CLRAO and optic disc edema was performed. All patients underwent multimodal imaging and systemic workup. Results: The patients were female, had a median age of 32 years, and were otherwise healthy. Presenting visual acuities were hand motion, 20/1000, and 20/70. One patient had optic nerve enhancement on magnetic resonance imaging. Systemic workups were noncontributory. All patients had ischemic retinal whitening and inner-retinal thinning in the cilioretinal artery (CLRA) distribution. Fluorescein angiography showed no signs of capillary nonperfusion, vascular inflammation, or frank vein occlusion. One patient was lost to follow-up and 2 were treated with high-dose corticosteroids with improvement in visual acuity. Conclusions: CLRAO can be associated with optic disc edema in the absence of outright central retinal vein occlusion, giant-cell arteritis, or known systemic disease.
Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma
Authors: Rosiñol Laura , Oriol Albert , Rios Rafael , Sureda Anna , Blanchard María Jesús , Hernández Miguel Teodoro , Martínez-Martínez Rafael , Moraleda Jose M. , Jarque Isidro , Bargay Juan , Gironella Mercedes , de Arriba Felipe , Palomera Luis , González-Montes Yolanda , Martí Josep M. , Krsnik Isabel , Arguiñano Jose M. , González Maria Esther , González Ana Pilar , Casado Luis Felipe , López-Anglada Lucia , Paiva Bruno , Mateos Maria-Victoria , San Miguel Jesus F. , Lahuerta Juan-José , Bladé Joan 
Published: September 2019

Key PointsVRD was effective and well tolerated before ASCT; 33.4% complete response/28.8% minimal residual disease–negative after 6 induction cycles. Responses deepened with VRD throughout induction and over the course of treatment with few discontinuations due to toxicity.