bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal and dental effects of skeletally anchored forsus fatigue resistant devices during class II malocclusion treatment: A meta-analysis and systematic review
Authors: Eissa Osama , Diar-Bakirly Samira , Saltaji Humam , El-Bialy Tarek 
Published: November 2024

OBJECTIVE:
To evaluate and compare the skeletal and dental treatment effects of Class II malocclusion cases using skeletally anchored Forsus (miniscrew-anchored FRD or miniplate-anchored FRD), with conventional Forsus FRD.

MATERIALS AND METHODS:
Unrestricted electronic search of six databases and additional manual searches were performed up to July 2023. Randomized controlled trials having one treatment arm with skeletal anchored Forsus FRD in treatment of Class II malocclusion and another matched treatment group treated with conventional Forsus FRD were included in this review. Risk of bias assessment was performed using Cochrane’s Risk of Bias Tool. No restrictions were set concerning treatment duration, or the cephalometric analysis used. Skeletal and dentoalveolar outcomes data were extracted by two authors independently.

RESULTS:
Three studies using miniscrews as means of skeletal anchorage were evaluated and qualified for the final review and meta-analysis. Three other studies using miniplates were considered in the systematic review but were not qualified for a meta-analysis. The data gathered from the miniscrews anchored FRD papers included a total of 93 Class II patients (46 treated with miniscrew-anchored Forsus FRD, 47 treated with conventional Forsus FRD). The meta-analysis showed a statistically significant reduction in the SNA angle in favor of miniscrew-anchored Forsus FRD (mean difference: −0.26, CI: −0.50 to −0.02), a nonsignificant difference in the SNB (mean difference: 0.17, CI: -0.06 to 0.39), a statistically significant increase in the SN–MP angle in favor of miniscrew-anchored Forsus FRD (mean difference: 0.53, CI: 0.06–1.00)—a statistically significant reduction in the L1-MP angle in favor of miniscrew-anchored Forsus FRD (mean difference: −2.12, CI: −4.96 to −2.12). Data from miniplate-anchored FRD included 31 Class II patients treated with mini plate anchored FRD. Although meta-analysis was not applicable to these studies, lower incisor inclination was observed to be less.

CONCLUSIONS:
Based on the existing evidence, the use of skeletal anchorage could not enhance forward mandibular growth. However, miniscrew-anchored Forsus FRD could minimize mandibular incisor protrusion while miniplates could even retract the mandibular incisor position with a headgear effect on the maxilla.
Exploring the association between orthodontic treatment and temporomandibular disorders in pediatric patient: A retrospective study
Authors: Pattanaik Snigdha , Veeraraghavan Vishnu P. , Dasari Arun K. , Sahoo Subhrajeet Narayan , Aileni Kaladhar Reddy , Suryawanshi Hema , Patil Santosh R. 
Published: November 2024

OBJECTIVE:
This retrospective study aimed to investigate the association between orthodontic treatment and development of temporomandibular disorders (TMDs) in pediatric patients.

METHODS:
This study analyzed 122 pediatric patients (age 10–18 years) who underwent orthodontic treatment. The inclusion criteria included comprehensive orthodontic records and substantial clinical documentation, while the exclusion criteria targeted preexisting TMDs or syndromes affecting the temporomandibular joint. Demographic details, treatment characteristics, and radiographic analyses, including standardized cephalometric measurements, were recorded. Clinical records were systematically reviewed for signs and symptoms of TMD, with categorization based on TMD severity using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD).

RESULTS:
Demographic characteristics revealed a mean age of 14.2 years, with a sex distribution of 36.9% males and 63.1% females. Pain, clicking/popping sounds, and limited jaw movement were reported by 23.0%, 16.4%, and 12.3% of the patients, respectively. TMD severity classification showed that 73.8% had no symptoms, 20.5% had mild symptoms, 4.1% had moderate symptoms, and 1.6% had severe symptoms. Statistical analyses revealed a significant association between TMD symptoms and sex (P = 0.023). Correlations among TMD severity, treatment duration (P = 0.036), and cephalometric changes were observed. Radiographic findings showed a moderate correlation with the gonial angle (r = 0.42) and a strong correlation with the condylar position (r = 0.58).

CONCLUSION:
This study provides insights into the complex relationship between orthodontic treatment and TMD development in pediatric patients. These findings suggest potential associations between treatment characteristics, cephalometric changes, and TMD symptoms.
A cross-sectional study to correlate nasal profile and chin position with cephalometric lip profile
Authors: Siddiqui Tania A. , Sukhia Rashna H. , Irfan Sarah , Hasan Ahmad , Fida Mubassar 
Published: November 2024

OBJECTIVE:
To determine the effect of the nose and chin on the cephalometric lip profile.

METHODS AND MATERIAL:
The pre-treatment lateral cephalograms of 177 adult patients with no history of orthodontic treatment were manually traced. The sample size was divided into three vertical and horizontal groups using angle ANB and MMA to assess the difference in nose and chin forms. The horizontal and vertical groups were analyzed using One-way ANOVA and Kruskal–Wallis. The Independent sample t-test and Mann–Whitney U were used for comparison between the two genders. The correlation of nose and chin with E, S line, and nasolabial angle was done using the Spearman correlation coefficient while the effect was assessed using linear regression analysis.

RESULTS:
Among the nasal variables, columellar length inversely affects the linear position of the upper lip and this was statistically significant. The nasolabial angle is also affected by the inclination of the nasal base and this was statistically significant. The linear distance of the soft tissue chin in relation to the maxilla has the most effect on the position of the upper lip. It is notable that all hard and soft tissue chin variables inversely affected the linear position of the upper and lower lips.

CONCLUSIONS:
The quantitative measure of the effect of the nose and chin on lips is important as it allows clinicians to determine the overall effect of adjunctive procedures at pretreatment levels. Thus, corrective procedures such as rhinoplasty or genioplasty can be done at pre-orthodontic treatment stages to create a better treatment plan for patients.
Investigating the Effectiveness of Enhanced Recovery after Surgery (ERAS) Protocols in Improving Postoperative Outcomes and Reducing Hospital Readmission Rates in Patients Undergoing abdominal Surgery
Authors: Shah Ali Akbar , Alnajib Alfatih Mohamed Ahmed , Baldaniya Lalji , Hassan Halijah , Kaur Parjinder , Sharma Rajesh , Ramzan Hafiza Sobia , Sami Waqas 
Published: November 2024

ABSTRACT

Objectives:
The main objective of the study is to determine the effectiveness of enhanced recovery after surgery (ERAS) protocols in improving postoperative outcomes and reducing hospital readmission rates in patients undergoing abdominal surgery.

Materials and Methods:
This study involves a total of 650 patients who were divided into two groups: the intervention group, which received care according to ERAS protocols, and the control group, which received standard postoperative care. Patients aged >18 years and scheduled for elective abdominal surgery were included in the study.

Results:
The mean age of patients in ERAS group were 56.4 ± 12.3 years, while in the standard care group 57.1 ± 11.8 years. Out of 650 patients, there were 339 male and 311 female. Patients were selected from different surgery departments. The ERAS group had lower 30-day readmission rates (6.2% vs. 15.4%), quicker mobilization (12.5 vs. 24.8 hours), and faster resumption of oral intake (8.6 vs. 18.2 hours). Pain levels were lower (VAS 3.1 vs. 5.8), and patient satisfaction was higher (89% vs. 74%) in the ERAS group, with all differences being statistically significant.

Conclusion:
It is concluded that ERAS protocols significantly improve postoperative outcomes, including reducing complications, shortening hospital stays, and lowering readmission rates for patients undergoing elective abdominal surgery.
Poncelet’s closure theorem and the embedded topology of conic-line arrangements
Authors: Bannai Shinzo , Masuya Ryosuke , Shirane Taketo , Tokunaga Hiro-o , Yorisaki Emiko 
Published: November 2024

AbstractIn the study of plane curves, one of the problems is to classify the embedded topology of plane curves in the complex projective plane that have a given fixed combinatorial type, where the combinatorial type of a plane curve is data equivalent to the embedded topology in its tubular neighborhood. A pair of plane curves with the same combinatorial type but distinct embedded topology is called a Zariski pair. In this paper, we consider Zariski pairs consisting of conic-line arrangements that arise from Poncelet’s closure theorem. We study unramified double covers of the union of two conics that are induced by a
$2m$
-sided Poncelet transverse. As an application, we show the existence of families of Zariski pairs of degree
$2m+6$
for
$m\geq 2$
that consist of reducible curves having two conics and
$2m+2$
lines as irreducible components.
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
Authors: Zhang Wan-Yu , Wang Han-Bi , Deng Cheng-Yan 
Published: November 2024

BACKGROUND
Thin endometrium seriously affects endometrial receptivity, resulting in a significant reduction in embryo implantation, and clinical pregnancy and live birth rates, and there is no gold standard for treatment. The main pathophysiological characteristics of thin endometrium are increased uterine arterial blood flow resistance, angiodysplasia, slow growth of the glandular epithelium, and low expression of vascular endothelial growth factor, resulting in endometrial epithelial cell (EEC) hypoxia and endometrial tissue aplasia. Human umbilical cord mesenchymal stem cells (HucMSCs) promote repair and regeneration of damaged endometrium by secreting microRNA (miRNA)-carrying exosomes. However, the initiation mechanism of HucMSCs to repair thin endometrium has not yet been clarified.
AIM
To determine the role of hypoxic-EEC-derived exosomes in function of HucMSCs and explore the potential mechanism.
METHODS
Exosomes were isolated from normal EECs (EEC-exs) and hypoxia-damaged EECs (EECD-exs), before characterization using Western blotting, nanoparticle-tracking analysis, and transmission electron microscopy. HucMSCs were cocultured with EEC-exs or EECD-exs and differentially expressed miRNAs were determined using sequencing. MiR-21-5p or miR-214-5p inhibitors or miR-21-3p or miR-214-5p mimics were transfected into HucMSCs and treated with a signal transducer and activator of transcription 3 (STAT3) activator or STAT3 inhibitor. HucMSC migration was assessed by Transwell and wound healing assays. Differentiation of HucMSCs into EECs was assessed by detecting markers of stromal lineage (Vimentin and CD13) and epithelial cell lineage (CK19 and CD9) using Western blotting and immunofluorescence. The binding of the miRNAs to potential targets was validated by dual-luciferase reporter assay.
RESULTS
MiR-21-5p and miR-214-5p were lowly expressed in EECD-ex-pretreated HucMSCs. MiR-214-5p and miR-21-5p inhibitors facilitated the migratory and differentiative potentials of HucMSCs. MiR-21-5p and miR-214-5p targeted STAT3 and protein inhibitor of activated STAT3, respectively, and negatively regulated phospho-STAT3. MiR-21-5p- and miR-214-5p-inhibitor-induced promotive effects on HucMSC function were reversed by STAT3 inhibition. MiR-21-5p and miR-214-5p overexpression repressed HucMSC migration and differentiation, while STAT3 activation reversed these effects.
CONCLUSION
Low expression of miR-21-5p/miR-214-5p in hypoxic-EEC-derived exosomes promotes migration and differentiation of HucMSCs into EECs via STAT3 signaling. Exosomal miR-214-5p/miR-21-5p may function as valuable targets for thin endometrium.
Genetic Characterization of Sumatran Mirah Chicken Based on Mitochondrial D-loop Region Sequence
Authors: Silalahi Parsaoran , Sitorus Tunggul Ferry , Putra Widya Pintaka Bayu 
Published: November 2024

Mirah chickens are Indonesian indigenous chickens that originate from Simalungun Regency, North Sumatera Province of Indonesia. The study aimed to determine the genetic characterization of Mirah chicken based on the mitochondrial D-loop region (838 bp). Twenty Mirah cocks from Simalungun Regency of Indonesia were used in the present study. The results showed that fourteen haplotypes were found in the studies of birds based on sixteen mutation sites. Therefore, these haplotype and nucleotide diversities in the partial D-loop region of the Mirah chicken were classified as high. The Median-joining tree revealed that the Mirah chickens were classified in a similar cluster with the Red jungle fowl (Gallus gallus). Ten haplotypes of birds were close to G. g. bankiva, and four haplotypes of birds were close to G. g. gallus. In conclusion, Mirah chickens had the genetic introgression from two sub-species of Red junglefowl, i.e., G.g. gallus and G.g. bankiva. Hence, the pure breeding program for Mirah chickens is important to conserve their genetic resources from extinction.
Right ventricular diverticulum following a pulmonary valve placement for correction of tetralogy of Fallot: A case report
Authors: Martinez Juarez David , Gomez Monterrosas Omar , Tlecuitl Mendoza Alonso , Zamora Rosales Francisco , Álvarez Calderón Rodrigo , Cepeda Ortiz Daniel A , Espinosa Solis Erick E 
Published: November 2024

BACKGROUND
Ventricular diverticula are a rare congenital cardiac disorder presenting with an extremely low incidence. The presence of an apical diverticulum of the right ventricle has been associated with other congenital heart diseases such as tetralogy of Fallot. An important defining characteristic of ventricular diverticula that separates them from aneurysms through imaging techniques, is that they possess myocardial contraction synchronous to the adjacent walls, contributing to the ventricular stroke volume, so they do not usually require surgical treatment.
CASE SUMMARY
A 15-year-old male, currently asymptomatic, in follow up due to a pulmonary valve prosthesis placement and a history of corrected tetralogy of Fallot at 18 months old, underwent a cardiac magnetic resonance imaging in February 2024. A diverticulum was detected in the apical inferolateral wall of the right ventricle, which was not documented in the cardiac magnetic resonance imaging prior to valve prosthesis placement.
CONCLUSION
Right ventricular diverticula are a rare entity. To this date we could not find another case of a pulmonary valve placement, followed by a right ventricular diverticulum appearance.
Improvement of financial results budgeting in the CSR contents
Authors: Khachatryan Qnarik 
Published: November 2024

Budgeting for financial results has traditionally been considered the preparation of cost and revenue estimates with responsibility centers in an organization. However, currently it covers a wider range, taking into account not only the internal but also the external value chain of the business. Currently, the value of organizations is not only evaluated by financial indicators, but also takes into account the responsibility of business from the point of view of ensuring public interests. The article makes recommendations for budgeting improvement of financial results, based on the requirements of companies corporate social obligations.
Assessment of the shadow economy and tax evasion in RA
Authors: Khalatyan Ani , Hakobyan Grigor 
Published: November 2024

This article aimed to assess the shadow economy and tax evasion in Armenia based on the indirect method of Currency Demand Approach (CDA). As the macroeconomic indicators in our analysis are not stationary at the same degree, we have used the autoregressive distributed lag (ARDL) models and the results of the co-integration test showed that there is a co-integration between the model variables, therefore it is possible to use the CDA.
In the model have been used monthly data during the 2013-2023 period. We can conclude that the CDA method can be considered to be an appropriate method for measuring the shadow economy and tax evasion in the RA’s economy. The results of the research show that during the observed years the level of the shadow economy and tax evasion are decreasing, which means that government is increasingly recognizes the importance to constrain the shadow economy given its connection to issues such as loss of tax revenues.
ՀԵՏԱԶՈՏԵԼՈՎ ԺԱՌԱՆԳՈՒԹՅՈՒՆԸ. ԱՐԱԲԵՐԵՆ ՀԻՄՆԱԲԱՂԱԴՐԻՉՈՎ ԵՎ ԱՐՀԵՍՏ, ՄԱՍՆԱԳԻՏՈՒԹՅՈՒՆ, ԶԲԱՂՄՈՒՆՔ ՆՇԱՆԱԿՈՂ ՀԱՅԿԱԿԱՆ ԱԶԳԱՆՈՒՆՆԵՐԻ ՎԵՐԼՈՒԾՈՒԹՅԱՆ ՓՈՐՁ
Authors: Տոնիկյան Սոնա , Քամալյան Արևիկ 
Published: November 2024

Ազգանունների ծագման ուսումնասիրությունը կարևոր նշանակություն ունի ցանկացած ազգի համար, քանի որ ազգանուններում արտացոլվում են տվյալ ազգի պատմությունն ու մշակույթը, կենցաղը։ Հայկական ազգանունների մեջ բավականին շատ են օտարալեզու բաղադրիչով ազգանունները, քանի որ հայ ժողովուրդը դարերով շփվել է տարբեր ազգերի հետ, գտնվել նրանց մշակութային, քաղաքական ու տնտեսական ազդեցության տակ, փոխառել բազմաթիվ բառեր։ Հոդվածում քննության են ենթարկվել արաբերեն հիմնաբաղադրիչով հայկական ազգանունները, որոնք նշանակում են արհեստ, մասնագիտություն և զբաղմունք։ Այդ բառերը հայերենը փոխառել է և՛ անմիջապես արաբերենից, և՛ միջնորդ լեզուներից՝ թուրքերենից ու պարսկերենից, այդ պատճառով հաճախ հայտնվել են ազգանվան տարբերակներ։ Այս հոդվածում փորձել ենք վեր հանել դրանց ծագումնաբանության հետ կապված խնդիրները՝ երբեմն առաջարկելով սեփական տարբերակները։ Մեր նպատակն է եղել հարստացնել գիտական խոսույթը՝ անդրադառնալով հայկական ազգանունների ստուգաբանության որոշ բացերին։
ԹՈՒՐՔ-ՀՈՒՆԱԿԱՆ «ԲԱՑ ԳԱՂՏՆԻՔ»․ ԲՆԱԿՉՈՒԹՅԱՆ ՓՈԽԱՆԱԿՄԱՆՆԵՐԿԱՅԱՑՈՒՄԸ Ջ․ ԹԱՆԻ «ԿԱՐՈՏ» ՎԵՊՈՒՄ
Authors: Պողոսյան Նաիրա Հ. 
Published: November 2024

20-րդ դարի վերջին 21-րդ դարի սկզբին թուրք գրականության մեջ տեղի ունեցող կարևորագույն փոփոխություններից էին՝ մի կողմից կին-գրողների աննախադեպ ակտիվությունը, մյուս կողմից էլ՝ բարձր գրականության և զանգվածային գրականության (վարդագույն վեպեր, դետեկտիվներ) միջև սահմանի յուրօրինակ լզոզումն ու բևեռայանացման նվազումը, յուրօրինակ միջին դասի գրականության ի հայտ գալը: Նմանատիպ վեպերում սյուժետաին ստանդարտ զարգացումներին զուգահեռ բարձրաձայնվում են բավական անսպասելի թեմաներ, այդ թվում անդրադարձներ թուրքական պատմության մինչ օրս քիչ լուսաբանված էջերին, ինչպիսին է թուրք-հունական բնակչության փոխանակումը։ Սույն հոդվածում անդրադարձ է կատարվում ժամանակակից կին-գրող Ջանան Թանի «Կարոտ» վեպում բնակչության փոխանակման ներկայացման առանձնահատկություններին։
Teknologi dan Komunikasi Antar Budaya: Peluang dan Tantangan di Dunia Digital
Authors: Widiyanarti Tantry , Rullah Agnini Dana , Fitriyani Devi , Silfa Finka Rayani , Nurfajri Ilham , Ayuningtyas Wulan Diah 
Published: November 2024

Penelitian kali ini membahas mengenai perkembangan teknologi digital telah mengubah cara masyarakat berkomunikasi melintasi batas geografis dan budaya. Teknologi informasi dan komunikasi (TIK) memungkinkan orang-orang dari latar belakang budaya yang berbeda untuk berinteraksi dengan lebih mudah dan cepat. Artikel ini membahas tentang peluang dan tantangan yang muncul dalam komunikasi antarbudaya di era digital. Di satu sisi, teknologi menciptakan peluang untuk memperluas pemahaman lintas budaya, meningkatkan kerja sama global, dan mendorong integrasi sosial. Namun, terdapat juga tantangan seperti perbedaan persepsi, stereotip budaya, dan risiko kesalahpahaman, yang dapat memperburuk ketegangan antar kelompok. Artikel ini juga menyoroti pentingnya literasi digital dan kompetensi antar budaya untuk memaksimalkan manfaat teknologi dalam menciptakan komunikasi yang efektif dan harmonis di dunia yang semakin terhubung.
Commentary on prescribing ethics and conflict of interest
Authors: Amna Rehana Siddiqui  , Mishal Sameer Khan  
Published: November 2024

The medical profession is inherently built on the pillars of trust, integrity and ethical conduct. Patients entrust their health, and often their lives, to medical practitioners, expecting that the care they receive is solely guided by the patient’s best interest. However, with the complexities of modern healthcare, these ethical standards are increasingly difficult to maintain. Conflict of interest in healthcare arises when the professional judgment of a healthcare provider is compromised such that they are at risk of not acting in the best interest of the patient because of the potential for personal gain.1-3 The theme of this supplement issue being conflict of interest (COI) affecting medical practice is a challenge particularly in the settings where regulatory systems are underresourced. Conflict of interest in health care provision not only occurs in physicians, but also among pharmacists and laboratory workforce. The healthcare provider-patient relationship is one of trust and confidence that the healthcare provider will act to maximize better health outcomes for the patient; therefore, the challenge of conflict of interest and unethical medical practices need to be addressed improving the quality of care and maintain trust in health systems.2-3
Continued...
ОБЗОР МИРОВЫХ ПРАКТИК ОЦЕНКИ СТОИМОСТИ ВЕНЧУРНЫХ КОМПАНИЙ-СТАРТАПОВ
Authors: А.Ю. Виноградов 
Published: November 2024

Оценка рыночной стоимости стартапов является одной из ключевых задач для инвесторов, предпринимателей и аналитиков. Правильное определение стоимости таких компаний на каждом этапе развития позволяет принимать обоснованные стратегические решения. Однако процесс оценки стартапов существенно отличается от оценки зрелых компаний, так как они часто обладают ограниченной финансовой историей, неопределенными перспективами роста и значительными рисками. Существует множество методик и подходов к оценке рыночной стоимости стартапов, каждая из которых имеет свои преимущества и ограничения. Одни методы основываются на анализе финансовых показателей, другие – на оценке потенциала рынка и уникальности продукта, третьи – на экспертных оценках и аналогиях с уже состоявшимися проектами. В данной статье рассмотрены наиболее распространенные мировые практики оценки стартапов.
Market valuation of startups is one of the key tasks for investors, entrepreneurs, and analysts. Properly determining the value of such companies at each development stage allows for making well-founded strategic decisions. However, the process of evaluating startups significantly differs from that of mature companies, as they often have limited financial history, uncertain growth prospects, and considerable risks. There are many methods and approaches to valuation the market value of startups worldwide, each with its own advantages and limitations. Some methods are based on the analysis of financial indicators, others on the assessment of market potential and product uniqueness, and still others on expert evaluations and analogies with already successful projects. This article examines the most common global practices for startups valuation.
Una Bibliografía de las formas
Authors: Irene Ortega López  
Published: November 2024

El presente artículo recorre una serie de prácticas de escritura que plantean un nuevo uso del texto dentro del contexto de la investigación artística en el ámbito académico y que conformaría la denominada “bibliografía de las formas”. Una aproximación que, lejos de atender a los textos como portadores de un conocimiento reproducible e iterable, rescata lo sensible y particular de cada uno de ellos. Atender a lo que el texto comunica desde su forma, así́ como los modos en los que se produce la escritura y la lectura. Un ensayo visual compuesto de imágenes-texto, que supone un cruce entre prácticas artísticas y prácticas de escritura.