bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of CVP and Fluid Overload are Associated with Sepsis-associated Acute Kidney Injury: a case-control study
Authors: Huang Minqiang , Han Wei , Han Ming , Kuang Lei 
Published: October 2019

Abstract
Background: The relationship between central venous pressure (CVP) and sepsis-associated acute kidney injury is not extensively explored. The study aimed to investigate the association of CVP and new-onset SAKI.Methods: Septic patients with new-onset AKI (SAKI) were identified from the Medical Information Mart for Intensive Care (MIMIC)-III database. Propensity score (PS) was used to account for the baseline differences between SAKI and non-SAKIs. In order to estimate association between CVP variability and AKI, we applied the generalize estimate equation (GEE) to adjust for potential confounding such as cumulative fluid balance and in-ICU medication usage. Results: A total of 916 septic patients with new-onset AKI were enrolled in the study, including 458 in the SAKI group and 458 in non-SAKI group. After PS matching, baseline factors such as SOFA, SAOSII, APSIII and LODS score, as well as baseline diseases including hypertension, diabetes, liver and renal disease were balanced between SAKIs and non-SAKIs. SAKI groups showed higher CVP variation (SAKI vs.non-SAKI:0.83 vs.0.68, p=0.03) and accumulative fluid balance (SAKI vs. non-SAKI: Day 1:3449.8 vs.2930.3; Day 2:4801.1 vs. 3916.6; Day 3: 6018.5 vs.5005.8, p=0.007). GEE was further used to estimate the association between CVP variation and SAKI. The model showed that, increased CVP variation (OR=1.14 ,95%CI 1.01-1.28, p=0.03), higher fluid accumulation (OR=1.02 95%CI 1.00-1.05, p=0.04) were associated with increased risk of SAKI. Conclusions: We found that variability of CVP and higher fluid accumulation were associated with higher risk of new-onset SAKI in septic patients in this study. The results need to be verified in further prospective trials.
Changes of the body posture in the sagittal plane of young adults during Matthiass test
Authors: Zawadka Magdalena , Kochman Maciej , Gawda Piotr , Jablonski Miroslaw 
Published: October 2019

Abstract
Background Postural assessment is an important part of the physical examination in the physical therapy practice. One of the most commonly used clinical tests is an arm-raising Matthiass test. The aim of this study was to investigate posture changes in sagittal plane observed during Matthiass test in young adults using a rasterstereography method. Methods Fourteen young and healthy volunteers, nine female and four male aged between 21 and 25 took part in this study. Examination s performed with the rasterstereographic measuring device. Results Trunk inclination significantly decreased during Matthiass test and the pelvis inclination increased. Distance between kyphosis apex and cervical lordosis apex was significantly shorter during the test than in standing position. Distance between kyphosis apex and lumbar lordosis apex significantly increased during Matthiass test. Kyphosis angle was significantly decreased and the lumbar lordosis angle was increased during the test. Conclusion The results of this study suggest that Matthias test can cause significant deviations in posture in young participants. Changes in the sagittal plane are observed mainly right after the elevation of the arms.
Birth asphyxia and its contributing factors among the neonates delivered at Negest Eleni Mohammed memorial teaching hospital, Southern Ethiopia: A cross-sectional study
Authors: Abdo Ritbano Ahmed , Halil Hassen Mosa , Kebede Biruk Assefa , Anshebo Abebe Alemu , Gejo Negeso Gebeyehu 
Published: October 2019

Abstract
Background : Birth asphyxia is a major contributor to neonatal mortality worldwide. In Ethiopia, birth asphyxia remains a severe condition that leads to significant mortality and morbidity. This study aimed to assess the prevalence and contributing factors of birth asphyxia among the neonates delivered at the Negest Eleni Mohammed Memorial Teaching Hospital, Southern Ethiopia. Methods: A hospital based cross-sectional study design was employed from June 1- 30, 2019. Two hundred seventy nine study participants were selected using the systematic sampling method. Data were collected using a pretested structured interviewer administered questionnaire, check list and chart review . Data were entered into Epi-data version 3.1 and analyzed using statistical package for social sciences version 24. Descriptive and binary logistic regression analysis were made and P value of < 0.05 was considered significant. Result: The overall prevalence of birth asphyxia among newborns was 15.1%. Factors that were significantly associated with birth asphyxia included mothers aged ≥ 35 [AOR=6.4, 95% CI (2.0, 20.5)], primigravida [AOR=5.1, 95% CI (2.0, 13.3)], prolonged second stage of labor [AOR=4.6, 95%CI (1.6, 13.3)], preterm birth [AOR=4.7, 95% CI (1.5, 14.1)], meconium stained amniotic fluid [AOR=7.5, 95% CI (2.5, 21.4)]and tight nuchal [AOR=3.1, 95% CI (1.2, 9.3)]. Conclusion: Birth asphyxia is still prevalent in the study setting. The results of this study show the need for better maternal care, creating awareness about contributing factors of birth asphyxia to the maternity health professionals, careful monitoring of labor, and identifying and taking proper measures that could help in reducing the occurrence of birth asphyxia.
Genome wide screen for mutations mediates sensitive to sodium dodecyl sulfate in budding yeast
Authors: Cao Chunlei , Cao Zhengfeng , Yu Peibin , Zhao Yunying 
Published: October 2019

Abstract
Background: Sodium dodecyl sulfate (SDS) is one of the most widely used anionic alkyl sulfate surfactants. Toxicological information on SDS is accumulating, however, mechanisms of SDS toxicity regulation remain poorly understood. In this study, the relationship between the SDS-sensitive mutants and their intracellular ROS levels has been investigated.
Results : Through a genome-scale screen, we have identified 108 yeast single-gene deletion mutants that are sensitive to 0.03% SDS. These genes were predominantly related to the cellular processes of metabolism, cell cycle and DNA processing, cellular transport, transport facilities and transport routes, transcription and the protein with binding function or cofactor requirement (structural or catalytic). We further measured the intracellular ROS (reactive oxygen species) levels of 108 SDS-sensitive mutants treated with 0.015% SDS. The results showed that 85 SDS-sensitive mutants accumulated significantly higher intracellular ROS levels under SDS stress than the wild-type cells. Moreover, SDS could generate oxidative damage and up-regulate several antioxidant defenses genes, and some of the SDS-sensitive genes were involved in this process.
Conclusion: This study provides insight on yeast genes involved in SDS tolerance and the elevated intracellular ROS caused by SDS stress. Our findings provide a basis to understand molecular mechanisms underlying the detoxification of SDS by yeast cells.
The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial
Authors: Qin Zhaojun , Xiang Chunyan , Li Hongbo , Liu Tingting , Zhan Leyun , Xia Zhengyuan , Zhang Min , Lai Jianpin 
Published: October 2019

Abstract
Background: Intravenous dexmedetomidine is known to attenuate stress response in patients undergoing laparoscopic surgery. We investigated whether the addition of the highly selective alpha-2 adrenergic agonist dexmedetomidine into ropivacaine for ultrasound-guided transversus abdominis plane block could inhibit stress response during laparoscopic surgery, and determined the optimal dose of dexmedetomidine in it.
Methods: One hundred and twenty-five patients undergoing laparoscopic gynecological surgery were included in this prospective and randomized double-blind study. Patients received general anesthesia with or without a total of 60 ml of 0.2% ropivacaine in combination with low (0.25 µg/kg), medium (0.50 µg/kg) or high dose (1.0 µg/kg) of dexmedetomidine for the four-quadrant transversus abdominis plane block ( n = 25). The primary outcomes were stress marker levels during the operation.
Results: One hundred and twenty patients completed the study protocol. Dexmedetomidine added to ropivacaine for transversus abdominis plane block significantly reduced serum levels of cortisol, norepinephrine, epinephrine, interleukin-6, blood glucose, mean arterial pressure and heart rate in a dose-dependent manner ( P < 0.05 ), accompanied with decreased anesthetic and opioid consumption during the operation ( P < 0.05 ), but the high dose of dexmedetomidine induced higher incidences of bradycardia than low or medium dose of dexmedetomidine ( P < 0.05 ).
Conclusion: The addition of dexmedetomidine at the dose of 0.5 µg/kg into ropivacaine for ultrasound-guided transversus abdominis plane block is the optimal dose to inhibit stress response with limited impact on blood pressure and heart rate in patients undergoing laparoscopy gynecological surgery.

Trial registration : This study was registered at www.chictr.org.cn on November 6th, 2016 (ChiCTR-IOR-16009753).
Keywords: Dexmedetomidine, Nerve block, Abdominal muscles, Stress response, Laparoscopy
A pragmatic pilot randomized phase II controlled trial of Prothrombin Complex Concentrates (PCC) versus Fresh Frozen Plasma (FFP) in adult patients who are Undergoing Heart Surgery (PROPHESY)
Authors: Green Laura , Roberts Neil , Cooper Jackie , Field Jane , Gill Ravi , Klein Andrew , Agarwal Seema , Stanworth Simom , Johnston Atholl , Monk Vivienne , O’Brien Ben 
Published: October 2019

Abstract
Background Fresh Frozen Plasma (FFP) is the accepted standard treatment for clotting factor replacement in bleeding patients during, or immediately after cardiac surgery. In the United Kingdom (UK) prothrombin complex concentrate (PCC) is not licensed in this setting although it is being used in Europe, because it has a higher concentration of clotting factor levels, and it can be administered rapidly and in small volume, resulting in less volume overload during cardiac surgery. Methods PROPHESY is a pragmatic single-centre, open-label, randomized, controlled pilot trial that will assess whether it is feasible to perform a large trial in the future that will compare PCC versus FFP in patients who are bleeding (not on warfarin) and who require blood transfusion. Over a 15-month period, 50 patients will be randomized to PCC versus FFP if they develop active bleeding within 24 hours of cardiac surgery, and for whom the clinician has decided to administer FFP for treatment of bleeding. Standard laboratory and Point-of-Care assessments will be performed as per routine practice, and additional research blood samples will be taken at three time-points to assess haemostasis. Subjects will be assessed daily up to hospital discharge or 30 days or death (whichever occurs first) and will be followed up for 90 days after surgery to assess for thromboembolic complications, and hospital re-admission since discharge. Quality of life assessment will be performed pre-surgery and at 90 days. We will also perform qualitative research with clinical experts and patients to explore the understanding and experience with the interventions, and adherence to study procedures and protocol. Discussion There have been no randomized control trials that have compared the safety and efficacy of FFP versus PCC in cardiac surgery in patients who are bleeding. This pilot study will assess if individual components of a large trial are deliverable to assess the safety and efficacy of the two blood products in the future.
SOCIAL CONSTRUTIVISMO E TEORIA DO ATOR-REDE: UMA ANÁLISE COMPARATIVA DE DOIS MÉTODOS DE PESQUISA EM SOCIOLOGIA DA CIÊNCIA E DA INOVAÇÃO
Authors: Dorigon Clovis , Bonamigo Irme Salete 
Published: October 2019

Este artigo aborda a relação entre ciência, tecnologia e sociedade, a partir das abordagens teórico-metodológicas de pesquisa: Social Construtivismo e Teoria do Ator-Rede, por meio da discussão de conceitos e estudos empíricos. Analisa as diferenças e suas implicações na utilização de uma ou outra abordagem enquanto método de pesquisa. O Social Construtivismo permite perceber que não há um determinismo tecnológico, pois o desenvolvimento de distintas tecnologias passa por um intenso processo de negociação social e que não existe, a priori, um único ou o melhor caminho. Já a Teoria do Ator-Rede possibilita tangenciar a dicotomia sociedade/natureza, pois parte do princípio que o mundo social e o mundo natural devem ser tratados de forma simétrica, pela composição de redes sociotécnicas.
Ödev Etiğinin Dini Etik Açısından Değerlendirilmesi
Authors: Yıldırım Ali 
Published: September 2019

Kant, ödev etiğini insanın özgürlüğü, ruhun ölmezliği ve
Tanrı’nın varlığı postulatları üzerine inşa etmiştir. Bu postulatlar aynı
zamanda, onun etik anlayışının ilahi buyruk etiği ile benzer ve farklı
yönlerine dair fikirler vermektedir. İlahi buyruk etiği, insandan Tanrı
tarafından gönderilen ahlak yasasına tam bir teslimiyeti ister. Ödev etiğinde
ise ahlak yasasına uyma temayülü dışsal bir motivi aşar. İnsanın, bilerek,
isteyerek ve her tür dışsal etkiden, arzu ve beklentilerini tetikleyecek
etkenlerden arınmış bir duyguyla eylemini seçmesi gerekmektedir. Diğer taraftan
“ödev” kavramı, insana insan olması bakımından tabiatına uygun davranma
yükümlülüğünü hatırlatır. Kant, bir bakıma ödevin, Tanrı’nın hatırlatmasına
gerek kalmaksızın, akıl sahibi insanın, yapması gerekeni bizzat kendi aklı ile
bilinçli olarak ve arzu ederek yapması gerektiğinden bahseder. Ancak pratikte
işler Kant’ın istediği gibi gitmeyebilir ve bu nedenle de Kant’ın ödev etiği
idealist bir teori olarak değerlendirilir. Bu noktada ilahi buyruk etiğinin
fonksiyonu devreye girer ve Kant’ın idealinde de yer alan “herkesin
isteyebileceği faydayı gözeten kurallardan” bahseder. Kant’ın, ahlaki
değerlerin kaynağını Tanrı olarak gösterdiği ve Tanrı’ya dayalı değerlerin
nesnelliğine işaret ettiği birçok ifadesine rastlamaktayız. Kant,
ahlaki dine dair düşüncelerini ifade ederken, “kalplerin, Tanrı’nın emirleri gibi tüm insani
ödevleri yerine getirmeye yatkın” oluşundan söz eder. Sonunda dinin biraz
farklı bir tanımına ulaşan Kant, “din tüm ödevlerin Tanrı’nın emirleri olarak
kabul edilmesidir” der. Dolayısıyla konuya ilişkin
görüşleri diğer eserleri ile birlikte okunduğunda, Kant’ın ahlak metafiziğinin
gözden geçirilmiş bir tür ilahi buyruk etiği olduğu fark edilmektedir. Öyle ki
Kant, kalıplaşmış dini pratiklerle statik bir hal alan tanrısal buyruğun, tüm
ilintilerinden sıyrılarak insan doğasına uygun bir formunu idealize etmektedir.
Bu nedenle bu çalışma, Kant’ın ödev etiğinin nihai anlamda bir tür ilahi buyruk
etiğine dönüşmek durumunda kaldığını iddia eder.
Calcium Pattern Assessment in Patients with Severe Aortic Stenosis Via the Chou’s 5-Steps Rule
Authors: Wiktorowicz Agata , Wit Adrian , Dziewierz Artur , Rzeszutko Lukasz , Dudek Dariusz , Kleczynski Pawel 
Published: September 2019

Background:Progression of aortic valve calcifications (AVC) leads to aortic valve stenosis (AS). Importantly, the AVC degree has a great impact on AS progression, treatment selection and outcomes. Methods of AVC assessment do not provide accurate quantitative evaluation and analysis of calcium distribution and deposition in a repetitive manner.Objective:We aim to prepare a reliable tool for detailed AVC pattern analysis with quantitative parameters.Methods:We analyzed computed tomography (CT) scans of fifty patients with severe AS using a dedicated software based on MATLAB version R2017a (MathWorks, Natick, MA, USA) and ImageJ version 1.51 (NIH, USA) with the BoneJ plugin version 1.4.2 with a self-developed algorithm.Results:We listed unique parameters describing AVC and prepared 3D AVC models with color pointed calcium layer thickness in the stenotic aortic valve. These parameters were derived from CT-images in a semi-automated and repeatable manner. They were divided into morphometric, topological and textural parameters and may yield crucial information about the anatomy of the stenotic aortic valve.Conclusion:In our study, we were able to obtain and define quantitative parameters for calcium assessment of the degenerated aortic valves. Whether the defined parameters are able to predict potential long-term outcomes after treatment, requires further investigation.
A Culturally Targeted eLearning Module on Organ Donation (Promotoras de Donación): Design and Development
Authors: Alolod Gerard P , Gardiner Heather , Agu Chidera , Turner Jennie L , Kelly Patrick J , Siminoff Laura A , Gordon Elisa J , Norden Robert , Daly Theresa A , Benitez Amanda , Hernandez Ilda , Guinansaca Nancy , Winther Lori Ramos , Bergeron Caroline D , Montalvo Antonette , Gonzalez Tony 
Published: October 2019

BackgroundAs an overrepresented population on the transplant waitlist, stagnated rates of organ donation registration among Latinxs must be redressed. Promotoras (community health workers), who are effective at advocating and spearheading health promotion efforts in the Latinx community, show promise in their ability to educate about organ donation and donor registration.ObjectiveThis study aimed (1) to develop an interactive, evidence-based program to educate promotoras about organ donation, the need for organ donors in the Latinx American community, and ways to register as deceased organ donors and (2) to train promotoras to lead discussions about organ donation and to promote the act of donor registration.MethodsIn partnership with 4 promotoras organizations, the culturally targeted Promotoras de Donación eLearning module was developed based on input from 12 focus groups conducted with Latina women (n=61) and promotoras (n=37). Formative work, existing literature, the Vested Interest Theory, and the Organ Donation Model guided curriculum development. In partnership with the Gift of Life Institute and regional promotoras, the curriculum was designed, filmed, and developed in a visually appealing module interface. The module was beta-tested with promotoras before launch.ResultsPromotoras de Donación, available in Spanish with English subtitling, lasts just over an hour. The module comprised 6 sections including various activities and videos, with the curriculum divided into a skills-based communication component and a didactic educational component. Pre- and posttests assessed the module’s direct effects on promotoras’ organ donation knowledge and attitudes as well as confidence promoting the act of donor registration.ConclusionsThis novel, theoretically and empirically based intervention leveraged the existing network of promotoras to promote the act of donor registration. Future research should assess whether the module helps increase rates of donor registration within Latinx communities and reduce disparities in access to transplantation.Trial RegistrationClinicalTrials.gov NCT04007419; https://www.clinicaltrials.gov/ct2/show/NCT04007419
La refracción negativa y los metamateriales: los nuevos materiales para dispositivos ópticos
Authors: Palomino Ovando Martha A. , Cocoletzi Gregorio H. 
Published: October 2019

En este trabajo describimos el efecto novel de la refracción negativa. Esta refracción anómala puede suceder en materiales artificiales: un tipo llamado metameteriales de índice de refracción negativa, en la cual la velocidad de fase es negativa y otro tipo de material de índice de refracción positiva donde la velocidad de grupo es positiva. Describimos modelos para la construcción de los materiales y damos ejemplos ilustrativos de la refracción negativa. También mencionamos algunas posibles aplicaciones de estos nuevos materiales como la construcción de lentes con superficies planas y materiales invisibles. En la fabricación de metamateriales que funcionen con luz visible, sus componentes deben tener tamaños en la nanoescala.
Educação Ambiental No Assentamento Filhos De Sepé: Contribuições De Uma Experiência
Authors: UFRGS PET GEOGRAFIA 
Published: September 2019

Este projeto tem como objetivo o desenvolvimento de atividades ligadas a educação em um assentamento da reforma agrária. A partir do desenvolvimento de um diagnóstico sócio-cultural de percepção ambiental no local, traçamos o objetivo fundamental deste projeto seguinte, que consiste na ampliação dos conceitos de ambiente, natureza, ecologia e educação ambiental das crianças, jovens e adultos do assentamento, com especial atenção na superação da visão antropocêntrica e individualista predominante na sociedade ocidental. Ele está estruturado em três pilares fundamentais: Dimensão Histórico-Cultural, Dimensão Sócio-Econômica e Dimensão Biogeográfica. Estas dimensões nos possibilitarão um desenvolvimento mais abrangente das experiências vividas, da relação com o meio ambiente, da relação com os movimentos do campo, das dificuldades enfrentadas, etc. Para atingirmos os nossos objetivos, utilizaremos os mais diferentes recursos pedagógicos, desde os mais tradicionais, até a utilização do teatro, da música, dos mapas mentais, etc. O descaso que existe em relação à educação por parte dos governantes em nosso país, somado com a necessidade de incluir aqueles que estão à margem de nossa sociedade, motiva o PET (Programa Educação Tutorial) Geografia ao desenvolvimento desta atividade tão instigante que é a educação ambiental.
Política de Formação de Professores: o Programa Institucional de Bolsa de Iniciação a Docência (PIBID) no Curso de Geografia/UFGD. Teoria e prática
Authors: Abreu Silvana De , Souza Adáutlo De Oliveira 
Published: September 2019

Resumo:O PIBID foi proposto como uma política de formação de professores e cumpre a função de aproximar a Universidade das escolas públicas. A experiência que vivenciamos, desde 2009, no curso de Geografia/UFGD, com a implantação do PIBID, tem representado a incorporação, no âmbito das escolas de nível básico em Dourados (MS), de práticas formadoras para todos os participantes e tem envolvido os acadêmicos no cotidiano da relação ensino-aprendizagem nas escolas, permitindo trocas significativas para o desenvolvimento de atividades integradas de ensino, pesquisa e extensão contribuindo para a busca compartilhada de alternativas didáticas orientadas para práticas educativas que possibilitem articulação e dinamização do processo de ensino e aprendizagem. Palavras-chave: PIBID; formação de professores; Ensino de Geografia.