bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone diagenesis study of the burials from the Pedra do Alexandre archaeological site, Carnaúba dos Dantas, RN
Authors: Lavalle Sullasi Henry Socrates , Santos André Luiz Campelo , Da Silva Sérgio Francisco Serafim Monteiro 
Published: November 2018

The Pedra do Alexandre archaeological site was a target of several archaeological campaigns, the bone remains from at least 36 human individuals, and charcoal fragments associated to these burials were among the archaeological findings of the campaigns. The radiocarbon dating provided values between 9400±90 BP and 2620±60 BP. However, attempts to dating the bone remain proved fruitless due to the loss of collagen caused by taphonomic processes. From that finding, this research was initiated to assess the degree of diagenetic alteration of the bone remains from the Pedra do Alexandre archaeological site. FTIR and XRD analyses conducted on 6 random human bone samples from the Site and pH measurements in correlated sediments has enabled us to conclude that all the analyzed bone remains were extensively degraded by microbial activity, although in different degrees of alteration.
Estudo da mobilidade logística a partir da caracterização química da cerâmica do sítio Capim em Araripina, Pernambuco, BR.
Authors: Sepúlveda Munita Casimiro , Ramos Carvalho Patrícia , Alves de Oliveira Cláudia , De Miranda Amaral Alencar , Lavalle Sullasi Henry Socrates 
Published: November 2018

Neste trabalho interdisciplinar, foi utilizada a análise de ativação de nêutrons (INAA) como o objetivo de determinar a composição química elementar de 57 fragmentos de cerâmica proveniente de cinco manchas de concentração do sítio arqueológico "Sitio do Capim" no estado de Pernambuco, no Brasil. O conjunto de dados foi analisado usando através de dendogramas e análise discriminante para a definição de grupos químicos. Os resultados mostraram três grupos químicos distintos, as diferenças, podem ser entendidas em termos de mobilidade desses grupos humanos devido à disponibilidade de matérias-primas.

Abstract: In this interdisciplinary work, we apply the neutron activation analysis (INAA) to determine the elementary chemical composition of 57 ceramic fragments from five areas of concentration from the archaeological site "Sitio do Capim" in Pernambuco state, in Brazil. The data set was analyzed by cluster dendogram and discriminant analysis for defining chemical groups. The results showed three distinct chemical groups and the differences can be understood in terms the mobility these human groups due the availability of raw materials.
Patrimônio pétreo paulistano: análise sob a ótica de propagação de ondas ultrassônicas
Authors: Del Lama Eliane Aparecida , Gimenez Alexander Martin Silveira , Grossi Danielle , Machado Diego Ferreira Ramos , Kuzmickas Luciane , Rodrigues Natália Mendonça 
Published: November 2018

A medição da velocidade de propagação de ondas ultrassônicas, método de análise não destrutivo, é uma técnica eficiente para avaliar o estado de conservação da rocha e a profundidade de penetração de consolidantes em monumentos. Este trabalho objetiva analisar monumentos pétreos da cidade de São Paulo com base nesta técnica. A superfície de acabamento é um ponto chave na obtenção dos dados, uma vez que superfícies polidas permitem o perfeito acoplamento dos transdutores, favorecendo a execução do ensaio de forma adequada. Os dados apontam rochas não alteradas ou ausência de fraturamento nos monumentos analisados. Abstract: Ultrasound pulse velocity, a non-destructive analytical method, is an efficient technique to evaluate the state of conservation of the rock and the depth of penetration of consolidants in monuments. This work aims to analyze stone monuments of the city of São Paulo based on this method. The finishing surface is a key point in obtaining the data, since polished surfaces allow the perfect coupling of the transducers, favoring the performance of the test in an appropriate manner. The data indicate unweathered rocks or absence of fractures in the analyzed monuments.
Um urbano pra lá de rural: as particularidades políticas, históricas e culturais que transformaram Campo Grande de arraial a capital
Authors: Attianesi Daniel , Passamani Guilherme Rodrigues 
Published: November 2018

A ideia do artigo proposto aqui está no questionamento sobre a possibilidade da cidade de Campo Grande se adequar aos moldes clássicos do pensado pela antropologia urbana. Ao pensar sobre a cidade de Campo Grande, estamos pensando em nexos constitutivos da própria realidade de diversas cidades brasileiras e do próprio Estado do Mato Grosso do Sul, cuja capital política e administrativa possui como sede o município de Campo Grande. Município esse que possuía uma população de 49.629 mil habitantes em 1940, que em 1970 já possuía 140.233 mil habitantes e nos últimos anos conta com uma população de 863.982 mil residentes, um crescimento de aproximadamente 1640% em 75 anos. Este artigo realizará uma análise da história de Campo Grande de forma a pensar a questão da relação entre rural e urbano. Para isso focaremos a partir da visão dos primeiros pensadores sociais, que pensavam a relação entra a vida na cidade e a vida no campo, autores como Weber, Simmel, Park, Wirth. Dessa forma, buscamos três momentos específicos dessa história: o primeiro sendo a formação de uma identidade cultural sul-mato-grossense entre os anos de 1932 a 1934, o segundo será pensar o momento de urbanização da cidade nos anos de 1960-1970 e o último iremos pensar a relação que a cidade possui atualmente com seus habitantes. Abstract: The idea of the proposed article is in questioning the possibility that the City of Campo Grande fits the classic models proposed by urban anthropology. When thinking about the City of Campo Grande, we are thinking in constitutive links with the reality of many Brazilian cities and with the very State of Mato Grosso do Sul, whose political and administrative capital is based in the City of Campo Grande. This city had a population of 49,629 in 1940, which in 1970 was already 140,233 and recent years count showed a population of 863,982 -- an increase of approximately 1640% in 75 years. This paper will analyze the history of Campo Grande in order to think about the relationship between rural and urban. For this, we will focus on the vision of the first social thinkers, who sought to think the relationship between life in the city and life in the countryside, authors like Weber, Simmel, Park, and Wirth. In this way, we look for three specific moments of this history: the first one being the formation of a cultural identity of the people of Mato Grosso do Sul from 1932 to 1934, the second is to think about the moment of the city’s urbanization in the years 1960-1970 and the latter we’ll think about the relationship that the city currently has with its inhabitants.
Arqueometria aplicada à conservação do patrimônio arqueológico metálico: Um estudo de caso do sítio funerário de São Gonçalo Garcia, Rio de Janeiro
Authors: Campos Guadalupe do Nascimento , Granato Marcus , Middea Antonieta , Lopes Ricardo Tadeu 
Published: November 2018

O presente trabalho apresenta alguns dos resultados obtidos no âmbito do projeto de pesquisa Conservação e Caracterização Microanalítica de Objetos Arqueológicos Metálicos, desenvolvido no Museu de Astronomia e Ciências Afins - MAST. O projeto tem como objetivo principal estabelecer metodologias de caracterização e conservação do patrimônio arqueológico metálico. Os artefatos selecionados para o estudo de caso são provenientes do Sítio Funerário da Igreja São Gonçalo Garcia (região central do Rio de Janeiro), relacionados aos séculos XVIII e XIX. Para os exames arqueométricos, foram empregadas as seguintes técnicas de caracterização: radiografia digital e microtomografia computadorizada de raios X, microscopias estereoscópica e eletrônica de varredura, espectroscopia de energia dispersiva (MEV/EDS) e difratometria de raios X. Foram obtidas informações sobre a composição dos artefatos (fase metálica e alguns produtos de corrosão), detalhes da morfologia em 3D não visíveis a olho nu, extensão da mineralização, dentre outros aspectos.

Abstract: This paper presents some of the achieved results in the "Microanalytical Conservation and Characterization of Metallic Archaeological Objects" research project, developed at the Museum of Astronomy and Related Sciences - MAST. The project's main goal is to establish methodologies for characterization and conservation of the metallic archaeological heritage. The artifacts selected for the case study are from the Funeral Site at São Gonçalo Garcia's Church (Rio de Janeiro's central region), related to the 18th and 19th centuries. For the archaeometric examinations, the following characterization techniques were employed: digital radiography and X ray microtomography, stereoscopic and scanning electron microscopy, energy-dispersive X ray spectroscopy (SEM / EDS) and X ray diffraction. Results were obtained about the artifacts's composition (metallic phase and some corrosion products), 3D morphology details invisible to the naked eye, and the extent of the mineralization, among other aspects.
Métodos de análise espacial para sítios arqueológicos: um modelo preditivo para o Estado de São Paulo
Authors: Constantino Perez Glauco , Coutinho Afonso Marisa , Mota Lúcio Tadeu 
Published: November 2018

Neste artigo, pretende-se apresentar um panorama dos métodos recentes de modelamento virtual para estimar a ocupação dos grupos ceramistas pela paisagem do estado de São Paulo. Para isso, utilizaram-se os métodos conhecidos como Método Kernel, Modelação IDW, Krigagem e Modelagem Simples Preditiva. Tais métodos podem corroborar a compreensão da dispersão dos grupos filiados às Tradições Itararé-Taquara e Tupiguarani nas paisagens oeste e sul paulista, permitindo a sua diferenciação não só a partir da caracterização cerâmica, mas também pelo seu posicionamento na paisagem. Ressalta-se, igualmente, a importância dos modelamentos preditivos virtuais para orientar os estudos futuros de arqueologia no estado de São Paulo. Abstract: In this article we intend to present an overview of the recent virtual modeling methods to estimate the occupation of ceramics groups in the landscape in the São Paulo state. For this we used the methods known as Kernel Method, IDW Modeling, Kriging and Simple Predictive Modeling. Such methods can corroborate to understand the dispersion of Itararé-Taquara and Tupiguarani Tradition in the western and southern regions in São Paulo, allowing their differentiation from, and not only, a ceramic characterization but also by their location in the landscape. We stress the importance of virtual predictive models to guide future archeological studies in the São Paulo state.
Arqueometria aplicada à conservação de sítios de arte rupestre
Authors: Lage Maria Conceição Soares Meneses , Farias Filho Benedito Batista 
Published: November 2018

A Arqueometria tem auxiliado muito a pesquisa arqueológica. No Piauí tem sido relevante também para auxiliar na conservação de sítios de arte rupestre. Os problemas de conservação existentes nestes sítios são numerosos e variados, de origem natural ou antrópica. É necessário conhecer a constituição química dos pigmentos, do suporte rochoso e de diferentes depósitos de alteração para se realizar diagnósticos e guiar as intervenções. Neste sentido tem-se utilizado principalmente aparelhos portáteis de análise ou aqueles que exigem um mínimo de amostras e não as destruam durante os estudos. As principais técnicas de exames e análises utilizados pelo grupo de pesquisa de Arqueometria da UFPI são microscopia portátil, espectroscopia Mössbauer portátil (MIMOS II), Espectrofotometria de Fluorescência X portátil e de bancada utiliza-se Espectrofotômetro Raman e Microscopia Eletrônica de Varredura. Exemplos de estudos são apresentados.

Abstract: Archaeometry has greatly aided archaeological research. In Piauí it has also been relevant to assist in the conservation of rock art sites. The conservation problems existing in these sites are numerous and varied, of natural or anthropic origin. It is necessary to know the chemical constitution of the pigments, the rocky support, and different alteration deposits to make diagnoses and guide the interventions. In this sense, we have mainly used portable analysis devices or those that require a minimum of samples and do not destroy them during the studies. The main techniques of examination and analysis used by the Archaeometry research group of the UFPI are portable microscopy, portable Mossbauer spectroscopy (MIMOS II), portable X-ray Fluorescence and bench-mounted Raman Spectrophotometer and Scanning Electron Microscopy. Examples of studies are presented.
The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis inDrosophilaand Preserves the Glial Fate
Authors: Trébuchet Guillaume , Cattenoz Pierre B. , Zsámboki János , Mazaud David , Siekhaus Daria E. , Fanto Manolis , Giangrande Angela 
Published: November 2018

Despite their different origins,Drosophilaglia and hemocytes are related cell populations that provide an immune function.Drosophilahemocytes patrol the body cavity and act as macrophages outside the nervous system, whereas glia originate from the neuroepithelium and provide the scavenger population of the nervous system.Drosophilaglia are hence the functional orthologs of vertebrate microglia, even though the latter are cells of immune origin that subsequently move into the brain during development. Interestingly, theDrosophilaimmune cells within (glia) and outside (hemocytes) the nervous system require the same transcription factor glial cells deficient/glial cells missing (Glide/Gcm) for their development. This raises the issue of how do glia specifically differentiate in the nervous system, and hemocytes in the procephalic mesoderm. The Repo homeodomain transcription factor and panglial direct target of Glide/Gcm is known to ensure glial terminal differentiation. Here we show that Repo also takes center stage in the process that discriminates between glia and hemocytes. First, Repo expression is repressed in the hemocyte anlagen by mesoderm-specific factors. Second, Repo ectopic activation in the procephalic mesoderm is sufficient to repress the expression of hemocyte-specific genes. Third, the lack of Repo triggers the expression of hemocyte markers in glia. Thus, a complex network of tissue-specific cues biases the potential of Glide/Gcm. These data allow us to revise the concept of fate determinants and help us to understand the bases of cell specification. Both sexes were analyzed.SIGNIFICANCE STATEMENTDistinct cell types often require the same pioneer transcription factor, raising the issue of how one factor triggers different fates. InDrosophila, glia and hemocytes provide a scavenger activity within and outside the nervous system, respectively. While they both require the glial cells deficient/glial cells missing (Glide/Gcm) transcription factor, glia originate from the ectoderm, and hemocytes from the mesoderm. Here we show that tissue-specific factors inhibit the gliogenic potential of Glide/Gcm in the mesoderm by repressing the expression of the homeodomain protein Repo, a major glial-specific target of Glide/Gcm. Repo expression in turn inhibits the expression of hemocyte-specific genes in the nervous system. These cell-specific networks secure the establishment of the glial fate only in the nervous system and allow cell diversification.
Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins
Authors: Sartor Gregory C. , Malvezzi Andrea M. , Kumar Ashok , Andrade Nadja S. , Wiedner Hannah J. , Vilca Samara J. , Janczura Karolina J. , Bagheri Amir , Al-Ali Hassan , Powell Samuel K. , Brown Peyton T. , Volmar Claude H. , Foster Thomas C. , Zeier Zane , Wahlestedt Claes 
Published: November 2018

Histone deacetylase (HDAC) inhibitors may have therapeutic utility in multiple neurological and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify BRD4, a BET bromodomain reader of acetyl-lysine histones, as an essential component involved in potentiated expression of brain-derived neurotrophic factor (BDNF) and memory following HDAC inhibition. Inin vitrostudies, we reveal that pharmacological inhibition of BRD4 reversed the increase inBDNFmRNA induced by the class I/IIb HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Knock-down of HDAC2 and HDAC3, but not other HDACs, increasedBDNFmRNA expression, whereas knock-down of BRD4 blocked these effects. Using dCas9-BRD4, locus-specific targeting of BRD4 to theBDNFpromoter increasedBDNFmRNA. In additional studies, RGFP966, a pharmacological inhibitor of HDAC3, elevatedBDNFexpression and BRD4 binding to the BDNF promoter, effects that were abrogated by JQ1 (an inhibitor of BRD4). Examining known epigenetic targets of BRD4 and HDAC3, we show that H4K5ac and H4K8ac modifications and H4K5ac enrichment at theBDNFpromoter were elevated following RGFP966 treatment. In electrophysiological studies, JQ1 reversed RGFP966-induced enhancement of LTP in hippocampal slice preparations. Last, in behavioral studies, RGFP966 increased subthreshold novel object recognition memory and cocaine place preference in male C57BL/6 mice, effects that were reversed by cotreatment with JQ1. Together, these data reveal that BRD4 plays a key role in HDAC3 inhibitor-induced potentiation ofBDNFexpression, neuroplasticity, and memory.SIGNIFICANCE STATEMENTSome histone deacetylase (HDAC) inhibitors are known to have neuroprotective and cognition-enhancing properties, but the underlying mechanisms have yet to be fully elucidated. In the current study, we reveal that BRD4, an epigenetic reader of histone acetylation marks, is necessary for enhancing brain-derived neurotrophic factor (BDNF) expression and improved memory following HDAC inhibition. Therefore, by identifying novel epigenetic regulators of BDNF expression, these data may lead to new therapeutic targets for the treatment of neuropsychiatric disorders.
Keberadaan Jentik Aedes aegypti di Kelurahan Karangjati
Authors: Raharjanti Noviyani Dwi , Pawenang Eram Tunggul 
Published: November 2018

Abstrak
Kasus DBD di Kecamatan Bergas cenderung meningkat, tahun 2016 Kelurahan Karangjati memiliki kasus DBD terbanyak yaitu sebesar 19 kasus. Dari studi pendahuluan pada 10 rumah, sebanyak 70% rumah positif terdapat jentik. Tujuan penelitian ini untuk mengetahui faktor yang berhubungan dengan keberadaan jentik Aedes aegypti. Jenis penelitian ini observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 93 rumah yang diambil dengan teknik proportional random sampling. Data dianalisis menggunakan uji chi square (α=0,05). Penelitian dilakukan pada bulan Mei 2018. Hasil menunjukkan bahwa kepadatan jentik termasuk dalam kategori tinggi. Hasil uji statistik menunjukan jumlah kontainer (p=0,006), jenis kontainer (p=0,017), volume kontainer (p=0,018), bahan kontainer (p=0,001), keberadaan tanaman pekarangan (p=0,001), praktik PSN (p=0,0001) berhubungan dengan keberadaan jentik Aedes aegypti. Sedangkan jumlah penghuni (p=0,436) dan status pekerjaan (p=0,347) tidak berhubungan dengan keberadaan jentik Aedes aegypti. Penelitian ini menyimpulkan bahwa variabel praktik PSN menjadi faktor paling dominan yang mempengaruhi keberadaan jentik Aedes aegypti..

Abstract
Trend of DHF in Bergas subdistricts has increased, in 2016 Karangjati village has the most cases of DHF with 19 cases. The preliminary survey on 10 homes, 70% have larvae. The purpose of this study to determine the factors associated with the presence of Aedes aegypti larvae. This was an explanatory research with cross sectional approach. The total amount of 93 houses sample was taken with propotional random sampling technique. Data were analyzed by chi-square test (α=0,05). The results showed that density figure on high level. This study was done on May 2018. Results of statistical test showed the number of containers (p=0,006), container type (p=0,0001), container volume (p=0,0001), container material (p=0,0001), gardens plant (p=0,001), practice PSN (p=0,0001) associated with the presence of Aedes aegypti larvae. While the number of occupants (p=0.436) and occupation (p=0.347) not related with presence of Aedes aegypti larvae. This study concludes that practice PSN becomes the dominant factor that affecting the presence of Aedes aegypti larvae.
Program Pelayanan Voluntary Counseling And Testing (VCT) di Puskesmas
Authors: Risqi Nisrina Dwi , Wahyono Bambang 
Published: November 2018

Abstrak
Data Puskesmas Duren menunjukkan jumlah kunjungan Voluntary Counseling and Testing (VCT) mengalami penurunan dalam tiga tahun dari 2015 hingga 2017. Pada tahun 2017 adanya kesenjangan antara jumlah kelompok wanita pekerja seksual dan lelaki suka lelaki yang ada di Kecamatan Bandungan dengan jumlah kunjungan VCT pada populasi kunci tersebut serta belum mencapai target yang ditetapkan oleh Dinas Kesehatan Kabupaten Semarang. Tujuan penelitian ini untuk mengetahui gambaran program pelayanan VCT di Puskesmas Duren. Penelitian ini dilakukan pada bulan Mei 2018. Jenis penelitian ini adalah deskriptif kualitatif. Informan penelitian terdiri dari 11 dipilih dengan teknik purposive sampling. Teknik pengumpulan data menggunakan wawancara dan observasi. Hasil penelitian menunjukkan kurangnya ketersediaan sarana dan prasarana serta sumber daya manusia di Puskesmas Duren. Sudah tersedianya dana dan standar operasional prosedur pelayanan VCT. Kegiatan sosialisasi layanan VCT sudah dilakukan. Pelaksanaan VCT belum sesuai dengan pedoman serta jumlah kunjungan VCT mengalami penurunan dalam tiga tahun terakhir dan belum mencapai target yang telah ditetapkan. Simpulan penelitian ini adalah gambaran program pelayanan VCT di Puskesmas Duren belum berjalan baik.

Abstract
Data from Duren Primary Health Center showed for the number of VCT visited decreased in three years from 2015 to year 2017. In 2017 there was gap between the number of women sex worker groups and men who were in Bandungan with their number of VCT visited. The purpose of this research was to know the description of VCT program in Duren Public Health Center. This research was conducted in May 2018. This type of research was descriptive qualitative. Research informants consisted of 11 selected by purposive sampling technique. Data collection techniques using interviews and observation. The results showed the lack of availability of facilities and infrastructure and human resources. Availability of funds and standard operational procedures were sufficiented. Socialization of VCT have been carried out. VCT implementation has not been in accordance with guidelines, the number of VCT visited has decreased in the last three years, and has not reached the targets. The conclusions of this study was the description of the VCT program have not gone well.
Synthesis, Spectral, Anticancer Studies on Cu (II) Complex of 2,4,5-Triphenyl-1H-Imidazole
Authors: Martak Fahimah , Candrawati Iin , Widyasari Ayu 
Published: November 2018

Schiff bases of 2,4,5-triphenyl-1H­-imidazole ligand and Cu(II) complex has been synthesized and characterized by 1H and 13C NMR, elemental analyses, molar conductance, thermal analysis (TGA), magnetic moment measurement, IR and UV-Vis. On the basis spectral studied and analytical data, it is evident that the Schiff base acts as monodentat ligand coordinating via nitrogen atom. The result showed that Cu(II) complex has octrahedral geometry. The studied complex was tested for anticancer activity. The anticancer activity of Cu(II) complex is evaluated against liver Carninoma (HEPG2) cell lines. These compound exhibites a moderate and weak activity against HCT 116 cell line with IC50 19.8 mM. DOI: http://dx.doi.org/10.15408/jkv.v0i0.3328