bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of oral propranolol and topical timolol in the treatment of infantile hemangioma: a meta-analysis and systematic review
Authors: Huang Xiaoye , Si Wenyue , Zou Zhili , Li Binyao , Mu Yide , Zhong Wei , Yang Kaiying 
Published: December 2024

BackgroundPropranolol, a nonselective β-blocker, is the first-line treatment for infantile hemangioma (IH). Topical timolol has recently been proposed as a novel IH treatment with fewer adverse effects. This study was conducted to compare the efficacy and safety of oral propranolol and topical timolol for treating IH.MethodsStudies were included after searching PubMed, Embase, Web of Science, and the Cochrane Library via the keywords of “propranolol”, “timolol”, “infantile hemangioma” and their synonyms. A meta-analysis with pooled odds ratios was performed using the fixed-effect model.ResultsSeven articles with 2071 patients were included in this meta-analysis. Compared with topical timolol, oral propranolol had a greater response rate (OR = 2.12, P &lt; 0.001), but it was also associated with a greater risk of adverse events (OR = 2.31, P &lt; 0.001). For superficial IH, timolol demonstrated similar efficacy to propranolol (OR = 1.28, P = 0.34) but with fewer adverse events (OR = 2.30, P = 0.001). Additionally, compared with topical timolol, propranolol at a dosage of 2 mg/kg/d had a better response rate (OR = 2.62, P &lt; 0.001), whereas the 1.0∼1.5 mg/kg/d propranolol group showed no significant difference (OR = 1.34, P = 0.38).ConclusionOral propranolol presents superior therapeutic efficacy in the treatment of IH compared to topical timolol. However, topical timolol can serve as an alternative to oral propranolol for treating superficial IH, providing similar efficacy with fewer adverse effects. Additionally, propranolol at a dosage of 2 mg/kg/d offers greater efficacy with a comparable safety profile, whereas the 1.0∼1.5 mg/kg/d propranolol dosage shows no significant difference in efficacy compared to timolol but is associated with more adverse events.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024603724, identifier CRD42024603724.
A comparative study of the quality differences and seasonal dynamics of flavonoids between the aerial parts and roots of Scutellaria barbata
Authors: Cheng Yijie , Cao Wenxin , Guo Ru , Chen Ruihuan , Li Xiaofan , Qian Da , Xu Jingyuan 
Published: December 2024

IntroductionScutellaria barbata D. Don is a widely cultivated Chinese herbal medicine known for its medicinal properties. However, differences in the spatial distribution of metabolites, accumulation patterns of flavonoids, and pharmacological activities between the aerial parts and roots of S. barbata still remain unclear, posing challenges for its standardized cultivation and quality control. This study aimed to elucidate the quality differences between these plant parts and clarify their seasonal variations.MethodsThe chemical profiles were qualitatively analyzed by UPLC-QTOF-MS/MS. The accumulation patterns of total flavonoids, scutellarin and baicalin in different parts of S. barbata were quantitatively analyzed by UV and HPLC respectively. The differences of pharmacological efficacy were evaluated by antioxidant assays and CCK-8 assay.ResultsIn this research, there were 46 compounds identified in S. barbata that included 44 flavonoids. The aerial parts primarily accumulate flavonoids with 4′-hydroxyl group, while the root mainly accumulate flavonoids without this group. Additionally, the accumulation and variation of flavonoid components were seasonally dependent, with the aerial parts reaching peak content in spring during vigorous vegetative growth and the roots accumulating most flavonoids in autumn. The extracts from both parts exhibited antioxidant activity and inhibitory effects on cancer cell proliferation, with notable differences between them.DiscussionThis study provides valuable insights into the quality differences and seasonal dynamics of the different parts of S. barbata, offering a reference for standardized harvesting and quality control.
Key role played by mesophyll conductance in limiting carbon assimilation and transpiration of potato under soil water stress
Authors: Beauclaire Quentin , Vanden Brande Florian , Longdoz Bernard 
Published: December 2024

IntroductionThe identification of the physiological processes limiting carbon assimilation under water stress is crucial for improving model predictions and selecting drought-tolerant varieties. However, the influence of soil water availability on photosynthesis-limiting processes is still not fully understood. This study aimed to investigate the origins of photosynthesis limitations on potato (Solanum tuberosum) during a field drought experiment.MethodsGas exchange and chlorophyll fluorescence measurements were performed at the leaf level to determine the response of photosynthesis-limiting factors to the decrease in the relative extractable water (REW) in the soil.ResultsDrought induced a two-stage response with first a restriction of CO2 diffusion to chloroplasts induced by stomatal closure and a decrease in mesophyll conductance, followed by a decrease in photosynthetic capacities under severe soil water restrictions. Limitation analysis equations were revisited and showed that mesophyll conductance was the most important constraint on carbon and water exchanges regardless of soil water conditions.DiscussionWe provide a calibration of the response of stomatal and non-stomatal factors to REW to improve the representation of drought effects in models. These results emphasize the need to revisit the partitioning methods to unravel the physiological controls on photosynthesis and stomatal conductance under water stress.
Stress, physical activity, and mindfulness practices among youth amidst COVID-19
Authors: El Hajj A. , Noulhiane M. , Andrieu B. , Heutte Natacha , Sirost O. 
Published: December 2024

IntroductionThe COVID-19 pandemic has exacerbated stress and anxiety among young people, particularly university students, impacting their mental well-being and daily life. Given the rise in social isolation and economic uncertainty, the adoption of mindfulness practices such as sophrology, meditation, and yoga becomes essential for improving their mental health. This study aims to evaluate the impact of these practices on stress levels and their effect on engagement in physical activities among youths.MethodThis study employed a mixed methods design to assess the impact of different wellness and mindfulness practices on stress levels and physical activity (PA) engagement among university students. Quantitative data were gathered electronically from 218 students at the University of Rouen and the university of Paris-Cité through validated questionnaires, including custom tools on sports and mindfulness practices and the Perceived Stress Scale (PSS). The sample consisted mainly of young adults aged 18 to 35, with a majority of 170 female and 48 male participants. Qualitative insights were gathered through semi-structured interviews with three directors of the university's sports and physical activities department (SUAPS), as well as four wellness program instructors. Data analysis involved statistical techniques using Statistical Analysis System (SAS) software for quantitative data, while qualitative data were analyzed thematically using Sphinx software, a tool for textual analysis. Ethical approval for the study was obtained, and confidentiality of all participants was maintained throughout the research.Results and conclusionThe COVID-19 pandemic had significant effects on French university students’ PA, mental health, and stress levels. Lockdowns led to a decline in sports practices for many, while others adapted by increasing their engagement in fitness and wellness practices. The majority of participants (64.68%) reported moderate levels of stress. A significant correlation was found between motivations for mental health support and stress management, and higher levels of stress (p = 0.0000 and p = 0.0024, respectively). Regular participation in wellness activities was associated with lower stress (p = 0.0193). The findings reinforce the idea that incorporating wellness practices into educational environments can strengthen students’ mental resilience and overall well-being, equipping them with essential tools to effectively cope with future stressors.
UV Sensitivities of Two Littoral and Two Deep-Freshwater Amphipods (Amphipoda, Crustacea) Reflect Their Preferred Depths in the Ancient Lake Baikal
Authors: Kondrateva Elizaveta , Gurkov Anton , Rzhechitskiy Yaroslav , Saranchina Alexandra , Diagileva Anastasiia , Drozdova Polina , Vereshchagina Kseniya , Shatilina Zhanna , Sokolova Inna , Timofeyev Maxim 
Published: December 2024

Solar ultraviolet (UV) is among the most important ecological factors shaping the composition of biota on the planet’s surface, including the upper layers of waterbodies. Inhabitants of dark environments recently evolving from surface organisms provide natural opportunities to study the evolutionary losses of UV adaptation mechanisms and better understand how those mechanisms function at the biochemical level. The ancient Lake Baikal is the only freshwater reservoir where deep-water fauna emerged, and its diverse endemic amphipods (Amphipoda, Crustacea) now inhabit the whole range from highly transparent littoral to dark depths of over 1600 m, which makes them a convenient model to study UV adaptation. With 10-day-long laboratory exposures, we show that adults of deep-water Baikal amphipods Ommatogammarus flavus and O. albinus indeed have high sensitivity to environmentally relevant UV levels in contrast to littoral species Eulimnogammarus cyaneus and E. verrucosus. The UV intolerance was more pronounced in deeper-dwelling O. albinus and was partially explainable by lower levels of carotenoids and carotenoid-binding proteins. Signs of oxidative stress were not found but UV-B specifically seemingly led to the accumulation of toxic compounds. Overall, the obtained results demonstrate that UV is an important factor limiting the distribution of deep-water amphipods into the littoral zone of Lake Baikal.
Screening and Genomic Profiling of Antimicrobial Bacteria Sourced from Poultry Slaughterhouse Effluents: Bacteriocin Production and Safety Evaluation
Authors: Peña Nuria , Lafuente Irene , Sevillano Ester , Feito Javier , Contente Diogo , Muñoz-Atienza Estefanía , Cintas Luis M. , Hernández Pablo E. , Borrero Juan 
Published: December 2024

Background/Objectives: Antimicrobial-resistant (AMR) pathogens represent a serious threat to public health, particularly in food production systems where antibiotic use remains widespread. As a result, alternative antimicrobial treatments to antibiotics are essential for effectively managing bacterial infections. This study aimed to identify and characterize novel antimicrobial peptides produced by bacteria, known as bacteriocins, as well as to recognize safe bacteriocin-producing strains, sourced from poultry slaughterhouse effluents. Methods: A total of 864 bacterial isolates were collected across eight stages of a poultry slaughter line and screened for antimicrobial activity against Gram-positive and Gram-negative indicator strains. Whole-genome sequencing (WGS) was performed on 12 selected strains, including Enterococcus faecium (6 isolates), Lactococcus lactis (1 isolate), Lactococcus garvieae (1 isolate) and Escherichia coli (4 isolates). The presence of bacteriocin gene clusters (BGC), antibiotic resistance genes (ARG), and virulence factors (VF) was analyzed. The antimicrobial activity of a novel bacteriocin was further evaluated using in vitro cell-free protein synthesis (IV-CFPS). Results: WGS revealed multiple BGCs, including a novel class IId bacteriocin, lactococcin P1A (LcnP1A), in L. lactis SWD9. LcnP1A showed antimicrobial activity against various indicator strains, including Listeria monocytogenes. While most bacteriocin-encoding strains harbored ARGs and VFs, E. faecium SWG6 was notable for its absence of ARGs and minimal VFs, highlighting its potential as a probiotic. Conclusions: These findings underscore the importance of discovering novel bacteriocins and safer bacteriocin producing strains to address antimicrobial resistance in the food chain. Further research would validate the efficacy of both the novel lactococcin P1A bacteriocin and the E. faecium SWG6 isolate for application in processed food and animal production systems.
The Phenomenon of Loan Words That Often Used in Social Media
Authors: Helmita Helmita 
Published: December 2024

This study uses Sociolinguistics theory, especially regarding the phenomenon of loan words in social media. The purpose of writing is to determine adoption, adaptation and levy from social media. Absorbed words serve to enrich vocabulary and provide more knowledge about foreign languages to Indonesian language users. Because it comes from a foreign language, of course there are some letters that are transliterated into Latin letters in accordance with the rules that apply in Indonesian. This research is descriptive qualitative research, using observation method. This research is what is often confusing when we are going to use absorbing words that are often mistaken in a writing. From this reasearch, the writer found that many words from english that aborbing and people used in social media.
Effect of Core Stability Exercise on Decreasing Angle of Trunk Rotation Degree in Idiophatic Scoliosis in Junior High School Student
Authors: Lathifa Windy , Sukadarwanto Sukadarwanto , Ghufroni Afif 
Published: December 2024

Background : Scoliosis is a group of conditions consisting of changes in the shape and position of the spine on the lateral side that may be accompanied by rotation caused by various etiologies. Core stability exercise is a form of exercise that can be used to reduce the degree of scoliosis curve
Objective : This study aims to determine the effect of core stability exercise on junior high school student (JHS).
Methods : This study used a one group pre and post test with control design involving 32 students of SMP 2 Wonosari Klaten who were divided into 2 groups, using the blind randomized control trial method. into 2 groups, namely a treatment group and a control group with a treatment group of 16 subjects as intervention group given treatment of core stability exercise and a control group of 16 subjects as control group without any treatment. The intervention was carried out for 5 weeks with a frequency of 3 times a week. Measuring the degree of the scoliosis curve using a scoliometer. The pre-test trunk rotation angle (ATR) value for the treatment group was found to be an average of 5.06º and a post-test ATR value of 4.75º. Meanwhile, in the control group, there was no change in the ATR value during the pre-test or post-test, which was 5.43º.
Result : Statistical test of differences in pre-post test of treatment groups using the Wilcoxon test obtained a value of p = 0.025 (p < 0.05).
Conculsion : From this study it was concluded that There is an effect of core stability exercise on reducing the scoliosis curve in junior high school student.
Platelet to Lymphocyte Ratio (PLR) Value in Normotency, Preeclampsia and Severe Preeclampsia
Authors: Sibagariang Rony Falty , Wibowo Bambang 
Published: December 2024

BACKGROUND : Hyperactivation of the inflammatory response in preeclampsia causes a significant increase in the number of leukocytes. Platelet to Lymphocyte Ratio (PLR) has been known as a marker of systemic inflammatory response. In preeclampsia, the role of PLR markers is still uncertain regarding the ability of clinical evaluation, differential diagnosis and evaluation of patient prognosis.
AIMS : To analyze differences in platelet to lymphocyte ratio (PLR) values in normotensive, preeclampsia, and severe preeclampsia pregnancies
METHOD : Analytical observational study with cross sectional design with 90 samples consisting of 30 normotensive pregnancies, 30 preeclampsia and 30 severe preeclampsia. Evaluation is carried out on the platelet to lymphocyte ratio (PLR) value. Analysis was carried out using the SPSS 32 edition application. Results are significant if p<0.05.
RESULT : Comparison between the normotensive group versus preeclampsia versus severe preeclampsia showed that platelet levels decreased but not significantly (p=0.081), lymphocyte levels increased significantly (p<0.001) and PLR values decreased significantly (p<0.001) as the degree of severity increased preeclampsia. In the severe preeclampsia group, the lowest platelet levels, the highest lymphocyte levels and the lowest PLR values were obtained. Patients with a PLR value < 104.62 have an 8.43x (OR 8.43; CI95% 3.12-22.78) higher risk of experiencing severe preeclampsia compared to subjects with a PLR value > 104.62.
CONCLUSION : The PLR value was significantly lowest in the severe preeclampsia group.
FACTORS AFFECTING THE UTILIZATION OF HEALTH SERVICES AMONG DIABETICS IN INDONESIA
Authors: Idris Haerawati , Mursyid Raja Salsabila 
Published: December 2024

Deaths in Indonesia are mostly caused by diabetes mellitus, a non-communicable disease due to a person's unhealthy lifestyle. The number of health facilities increases annually with the high prevalence of diabetes cases in Indonesia. This study aims to analyze factors affecting the utilization of health services among diabetic people in Indonesia. It was a quantitative study with a cross sectional design, using secondary data of IFLS-5. The theory used was the Andersen's health service utilization model. A multistage random sampling was used to obtain 534 user data that matched the inclusion and exclusion criteria. Data were analyzed using the chi-square analysis and logistic regression. The results showed that the number of respondents who used inpatient services was 16.9%, and that who used outpatient was 44.4%. The variables that were significantly related to the utilization of inpatient and outpatient health services in diabetic people were socio demographic caracteristic, ownership of health insurance, perception of health status, suffering from chronic diseases and daily activities. It is important for policymakers in the health sector must improve financial or economic access to health services, as well as health service equity in all regions.
Personalised Surgical Site Infection Prophylaxis Based on Bile Cultures in Patients Undergoing Pancreaticoduodenectomy: A Clinical Trial Protocol
Authors: Курсенко Роман Вадимович , Трушин Антон Александрович , Вервекин Илья Валерьевич , Купенская Татьяна Владимировна , Тен Олег Андреевич , Захаренко Александр Анатольевич , Удоратин Олег Александрович 
Published: December 2024

Введение. Частота инфекционных осложнений области хирургического вмешательства (ИОХВ) после панкреатодуоденальных резекций (ПДР) остаётся высокой. Микробная обсеменённость желчи: бактериобилия, возникающая на фоне предоперационного билиарного дренирования (ПБД), у данной когорты пациентов встречается с высокой частотой. Несмотря на многофакторность причин, влияющих на развитие ИОХВ после ПДР, бактериобилия, представляется одним из наиболее значимых факторов развития ИООВ. Бактериальная культура итраоперационного посева желчи и микробиом ИОХВ представлены, в большинстве случаев, патогенами, резистентными к стандартной периоперационной антибиотикопрофилактике. С целью снижения частоты ИОХВ после ПДР необходим дальнейший поиск методов воздействия на бактериобилию, в том числе пересмотр подходов в периоперационном назначении антибактериальных средств.
Материалы и методы. Планируется одноцентровое когортное сравнительное клиническое исследование с ретроспективной и проспективной группами. Будут проанализированы группы пациентов с опухолями периампулярной зоны, которым выполнялось предоперационное билиарное дренирование с последующей ПДР. В обеих группах будет производиться анализ микробиома желчи из билиарного дренажа. В контрольной ретроспективной группе будет применяться стандартная периоперационная антибиотикопрофилактика (ПАП), в то время как в исследуемой проспективной группе будет применяться персонализированная ПАП на основе данных посева желчи из билиарного дренажа, полученных перед ПДР. В обеих группах как первичная конечная точка будет произведена оценка частоты ИОХВ после ПДР. Ожидаемая частота инфекционных послеоперационных осложнений в основной группе — 15 %, в контрольной группе — 40 %. При вероятности ошибке первого рода (α) = 0,05, ошибки второго рода (β) = 0,2, мощность исследования составит (1-β) = 0,8. Исходя из расчета по формуле Лера, объем каждой группы должен составить не менее n = 49.
Выводы. На основании результатов исследования будет произведена оценка необходимости применения персонализированной ПАП у пациентов с ПБД, которым планируется ПДР по поводу периампулярных опухолей.
D2 Gastrectomy in Combination with Simultaneous Pressurized Intraperitoneal Chemotherapy (PIPAC) for Gastric Cancer: Immediate Results of the GASPACCO Clinical Trial Protocol. Safety Analysis
Authors: Захаренко Александр Анатольевич , Беляев Михаил Алексеевич , Свечкова Анна Алексеевна , Вервекин Илья Валерьевич , Хамид Абдо Херреддин , Палтышев Илья Александрович , Багненко Сергей Федорович , Вовин Кирилл Николаевич , Купенская Татьяна Владимировна 
Published: December 2024

Введение. Внутрибрюшинная аэрозольная химиотерапия под давлением (PIPAC) — новый метод регионарной химиотерапии. До настоящего времени нет единого мнения о безопасности применения PIPAC в сочетании с резекционными и реконструктивными вмешательствами в хирургическом лечении рака желудка.
Материалы и методы. В данный анализ безопасности включены 52 пациента, прошедшие лечение по протоколу клинического исследования GASPACCO (ClinicalTrials.gov № NCT04595929). Больные рандомизированы на 2 равные группы: контрольная (24 пациента) — периоперационная химиотерапии с последующей гастрэктомией и лимфодиссекцией D2; группа PIPAC (28 пациентов) — периоперационная химиотерапия, гастрэктомия с лимфодиссекцией D2 и интраоперационной аэрозольной химиотерапией (PIPAC) препаратами: Цисплатин — в дозе 7,5 мг/м² и Доксорубицин — 1,5 мг/м².
Результаты. Значимой статистической разницы по интраоперационным показателям не наблюдалось (кровопотеря, длительность операции). При оценке гематологической, почечной, печеночной и гастроинтестинальной токсичности на 3 и 7 сутки послеоперационного периода по критериям CTCAE ver 5.0, статистически значимой разницы не выявлено. Обнаружена статистически значимая разница по уровню болевого синдрома на I сутки у пациентов группы PIPAC интенсивность болевого синдрома была выше, чем у больных контрольной группы. В обеих группах больных наблюдалось равное количество осложнений.
Выводы. Проведение методики PIPAC симультанно с радикальным вмешательством является безопасной, выполнимой и может использоваться у больных с местно-распространённым раком желудка. Исследование зарегистрировано на ClinicalTrials.gov № NCT04595929.