bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molybdenum Disulfide Surface Modification of Ultrafine-Grained Titanium for Enhanced Cellular Growth and Antibacterial Effect
Authors: Shin Myeong Hwan , Baek Seung Mi , Polyakov Alexander V. , Semenova Irina P. , Valiev Ruslan Z. , Hwang Woon-bong , Hahn Sei Kwang , Kim Hyoung Seop 
Published: June 2018

AbstractThe commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse- and ultrafine-grained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions
Authors: Yu Zhou , Ma Jing , Li Xia , Liu Yixiong , Li Mingyang , Wang Lu , Zhao Ming , He Huiying , Zhang Yifen , Rao Qiu , Zhao Danhui , Wang Yingmei , Fan Linni , Li Peifeng , Liu Yang , Liu Fang , Zhang Feng , Ye Jing , Yan Qingguo , Guo Shuangping , Wang Zhe 
Published: June 2018

AbstractThe relationship between autophagy and tumour is well studied, but tumour cell morphological changes associated with autophagy defects are rarely reported, especially in renal cell carcinoma (RCC). We collected 10 renal tumour samples with characteristic eosinophilic cytoplasmic inclusions (ECIs) and found that the ECIs were majorly composed of sequestosome 1/P62, neighbor of BRCA1 gene 1 (NBR1), PEX14, and CATALASE1 (CAT1). Further, transmission electron microscopy analysis revealed that ECIs were aggregates of proteinaceous material and peroxisomes. These results confirmed that ECIs in RCCs were the products of autophagy defects. The presence of ECIs was correlated with high Fuhrman grade components of RCCs. Whole-exome sequencing (WES) and Sanger sequencing confirmed that tumours with ECIs showed somatic mutations or high frequency of genetic variations in autophagy-related (ATG) genes, such as ATG7, ATG5, and ATG10. These results indicate that nucleotide changes in ATG genes are associated with autophagy defect, ECI formation, and even tumour grade in RCCs.
Black-headed gulls synchronise their activity with their nearest neighbours
Authors: Evans Madeleine H. R. , Lihou Katie L. , Rands Sean A. 
Published: June 2018

AbstractAnimals in groups can benefit from synchronising their behaviour, where multiple individuals conduct similar activities at the same moment in time. Previous studies have demonstrated that some species show synchronisation of vigilance behaviour, but have not explored the mechanism driving this behaviour. Synchronisation could be driven by animals copying their closest neighbours, which would mean that close proximity should lead to increased synchronisation. We simultaneously observed the behaviour of multiple individual black-headed gulls (Chroicocephalus ridibundus) within resting groups, and compared the activity of a focal individual with its two closest neighbours and a randomly selected control individual. Focal individuals were more likely to be synchronised with their closest neighbour. Synchronisation became less likely if individuals were not the closest neighbour. This suggests that synchronisation seen within groups is dependent upon the spatial positions of its members, and black-headed gulls pay more attention to their closest neighbours.
Resistance to CymMV and ORSV in artificial microRNA transgenic Nicotiana benthamiana plants
Authors: Petchthai Udomporn , Yee Celestine Shi Le , Wong Sek-Man 
Published: June 2018

AbstractTransgenic plants expressing artificial microRNAs (amiRNAs) have been shown to confer specific resistance to corresponding viruses. Here, we generated Nicotiana benthamiana transgenic lines containing Oryza sativa miR528 as backbone, expressing amiRNAs targeting RNA-dependent RNA polymerase (RdRp) gene of Cymbidium mosaic virus (CymMV) and Odontoglossum ringspot virus (ORSV). The amiRNA transgenic lines could express amiR-CymMV and confer high percentage resistance to CymMV, while lack of detectable level of amiR-ORSV expression in amiR-ORSV transgenic N. benthamiana plants led to weak resistance to ORSV infection. In this project, we provide the first report of CymMV-resistant transgenic N. benthamiana plants based on amiRNA strategy. We believe that this amiRNA approach can be extended to generate CymMV-resistant transgenic orchids.
Time-lapse imagery and volunteer classifications from the Zooniverse Penguin Watch project
Authors: Jones Fiona M. , Allen Campbell , Arteta Carlos , Arthur Joan , Black Caitlin , Emmerson Louise M. , Freeman Robin , Hines Greg , Lintott Chris J. , Macháčková Zuzana , Miller Grant , Simpson Rob , Southwell Colin , Torsey Holly R. , Zisserman Andrew , Hart Tom 
Published: June 2018

AbstractAutomated time-lapse cameras can facilitate reliable and consistent monitoring of wild animal populations. In this report, data from 73,802 images taken by 15 different Penguin Watch cameras are presented, capturing the dynamics of penguin (Spheniscidae; Pygoscelis spp.) breeding colonies across the Antarctic Peninsula, South Shetland Islands and South Georgia (03/2012 to 01/2014). Citizen science provides a means by which large and otherwise intractable photographic data sets can be processed, and here we describe the methodology associated with the Zooniverse project Penguin Watch, and provide validation of the method. We present anonymised volunteer classifications for the 73,802 images, alongside the associated metadata (including date/time and temperature information). In addition to the benefits for ecological monitoring, such as easy detection of animal attendance patterns, this type of annotated time-lapse imagery can be employed as a training tool for machine learning algorithms to automate data extraction, and we encourage the use of this data set for computer vision development.
Anticancer activity evaluation of green synthesised gold–silver alloy nanoparticles on colourectal HT‐29 and prostate DU‐145 carcinoma cell lines
Authors: Entezari Heravi Reza , Zakeri Sajad , Nazari Pardis 
Published: June 2018

Nanotechnology is an interesting way to produce and deal with fascinating features of materials. Metal nanoparticles offer a vast spectrum of potential applications in medicine and pharmaceutical sciences due to advances in nanotechnology research. This study was aimed to evaluate the anticancer properties of gold–silver (Au–Ag) alloy nanoparticles, which were synthesised using a green method by Galega officinalis ethanolic extract. The antitumour activity of biosynthesised nanoparticles has been assessed in vitro using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay on DU‐145 and HT‐29, prostate and colon cell lines, respectively. The Au–Ag alloy nanoparticles activity to inhibit the growth of cancer cell lines was recorded in terms of decrease in viable cell count in comparison with the control value. The spherical Au–Ag alloy nanoparticles with average size of 100 nm diameter were synthesised. The growth inhibition of the human prostate (DU‐145) and colon carcinoma cell line (HT‐29) has been found to be dose dependent. The calculated IC50 for the DU‐145 cell line was 95.78 μg/ml after 24 h and for the HT‐29 cell line was 70.66 µg/ml after 48 h. The results of this study suggest that Au–Ag alloy nanoparticles could be as an active substance against tumour cell lines and may be a beneficial treatment for cancer.
Molecular gas in two companion cluster galaxies at z = 1.2
Authors: Castignani G. , Combes F. , Salomé P. , Andreon S. , Pannella M. , Heywood I. , Trinchieri G. , Cicone C. , Davies L. J. M. , Owen F. N. , Raichoor A. 
Published: June 2018

Context. Probing both star formation history and evolution of distant cluster galaxies is essential to evaluate the effect of dense environment on shaping the galaxy properties we observe today.
Aims. We investigate the effect of cluster environment on the processing of the molecular gas in distant cluster galaxies. We study the molecular gas properties of two star-forming galaxies separated by 6 kpc in the projected space and belonging to a galaxy cluster selected from the Irac Shallow Cluster Survey, at a redshift z = 1.2, that is, ~ 2 Gyr after the cosmic star formation density peak. This work describes the first CO detection from 1 < z < 1.4 star-forming cluster galaxies with no clear reported evidence of active galactic nuclei.
Methods. We exploit observations taken with the NOEMA interferometer at ~3 mm to detect CO(2−1) line emission from the two selected galaxies, unresolved by our observations.
Results. Based on the CO(2−1) spectrum, we estimate a total molecular gas mass M(H2) = (2.2+0.50.4) × 1010 M⊙, where fully excited gas is assumed, and a dust mass Mdust < 4.2 × 108 M⊙ for the two blended sources. The two galaxies have similar stellar masses and Hα-based star formation rates (SFRs) found in previous work, as well as a large relative velocity of ~400 km s−1 estimated from the CO(2−1) line width. These findings tend to privilege a scenario where both sources contribute to the observed CO(2−1). Using the archival Spitzer MIPS flux at 24 μm we estimate an SFR (24μm) = (28+12−8) M⊙/yr for each of the two galaxies. Assuming that the two sources contribute equally to the observed CO(2−1), our analysis yields a depletion timescale of τdep = (3.9+1.4−1.8) × 108 yr, and a molecular gas to stellar mass ratio of 0.17 ± 0.13 for each of two sources, separately. We also provide a new, more precise measurement of an unknown weighted mean of the redshifts of the two galaxies, z = 1.163 ± 0.001.
Conclusions. Our results are in overall agreement with those of other distant cluster galaxies and with model predictions for main sequence (MS) field galaxies at similar redshifts. The two target galaxies have molecular gas mass and depletion times that are marginally compatible with, but smaller than those of MS field galaxies, suggesting that the molecular gas has not been sufficiently refueled. We speculate that the cluster environment might have played a role in preventing the refueling via environmental mechanisms such as galaxy harassment, strangulation, ram-pressure, or tidal stripping. Higher-resolution and higher-frequency observations will enable us to spatially resolve the two sources and possibly distinguish between different gas processing mechanisms.
Revised Gaia Data Release 2 passbands
Authors: Weiler Michael 
Published: June 2018

Context. The European Space Agency mission Gaia has published, with its second data release (DR2), a catalogue of photometric measurements for more than 1.3 billion astronomical objects in three passbands. The precision of the measurements in these passbands, denoted G, GBP, and GRP, reach down to the milli-magnitude level. The scientific exploitation of this data set requires precise knowledge of the response curves of the three passbands.
Aims. This work aims to improve the exploitation of the photometric data by deriving an improved set of response curves for the three passbands, allowing for an accurate computation of synthetic Gaia photometry.
Methods. This is achieved by formulating the problem of passband determination in a functional analytic formalism, and linking the photometric measurements with four observational, one empirical, and one theoretical spectral library.
Results. We present response curves for G, GBP, and GRP that differ from the previously published curves, and which provide a better agreement between synthetic Gaia photometry and Gaia observations.
Does the Degree of Acculturation Influence Breastfeeding Intention and Start or the Frequency of Early Weaning? Results of a Prospective Observational Study
Authors: Brenne Silke , Breckenkamp Jürgen , Borde Theda , David Matthias , Razum Oliver 
Published: June 2018

Abstract
Objectives Recent breastfeeding studies from immigration countries have found that acculturation factors influence breastfeeding behaviour in women with a migration background. To date, there has been no systematic investigation for Germany. Therefore, we study whether and how the degree of acculturation within a population of migrant women influences the start, time and duration of breastfeeding.
Patient Population and Methodology Pregnant women who were admitted to one of the three participating maternity clinics in Berlin for the birth of their child in the one-year study period were surveyed (including sociodemographic details, data on migration/acculturation). These women were interviewed again two or three days post partum (including start of breastfeeding, planned breastfeeding duration, reasons for not breastfeeding). In a subgroup, a telephone interview took place 6 months post partum about the actual breastfeeding duration, contraceptive behaviour post partum and availing of midwife services following delivery. Breastfeeding behaviour was analysed using multivariate regression models, among other things.
Results The prepartum survey included 7100 women, 6884 women were contacted in the postnatal wards, and the subgroup six months after delivery comprised 605 women. No acculturation-related differences were found in the start of breastfeeding. In the adjusted model, a medium and higher degree of acculturation diminished the chance of planning a long breastfeeding period. More acculturated women show a greater risk of weaning within the first six months than less acculturated women.
Conclusion The degree of acculturation has relevant significance for some aspects of breastfeeding behaviour in women with a migration background. This should be considered both in breastfeeding promotion programmes and in further national breastfeeding studies.
Wasser kontra Schmerz – Hydrotherapeutische Anwendungen in der Schmerzbehandlung
Authors: Gündling Peter W. 
Published: June 2018

ZusammenfassungObwohl hydrotherapeutische Maßnahmen etwas in Vergessenheit geraten sind, bieten sie wertvolle Optionen im Rahmen einer ganzheitlich-naturheilkundlichen Therapie. Als typische Regulationsverfahren wirken sie ausgleichend auf die Aktivität des vegetativen Nervensystems und tragen so zur Normalisierung des Muskeltonus, des Stoffwechsels und der Durchblutung bei. Damit können – mit relativ geringem Aufwand – nicht nur medikamentöse und andere nicht medikamentöse Maßnahmen ergänzt und verstärkt, sondern auch die Selbsthilfefähigkeit der Patienten wirksam unterstützt werden.
Myoreflextherapie im Sport: Fälle aus der Praxis
Authors: Mosetter Kurt 
Published: June 2018

ZusammenfassungBei der Myoreflextherapie geht es um die unmittelbare Lösung der zu hohen Grundspannung im Muskel/Muskelsystem und damit um die Entlastung von Gelenken und Weichteilstrukturen. Bereits leichte Druckerhöhungen können zu Schmerzen mit Ausstrahlung an entfernte Stellen führen.Anhand von typischen Fällen werden häufige Beschwerden aus der sportmedizinischen Praxis, deren myoreflextherapeutische Behandlung und die möglichen Erfolge gezeigt.
Influence of Training of Orthopaedic Surgeons on Clinical Outcome after Total Hip Arthroplasty in a High Volume Endoprosthetic Centre
Authors: Osmanski-Zenk Katrin , Finze Susanne , Lenz Robert , Bader Rainer , Mittelmeier Wolfram 
Published: June 2018

Zusammenfassung
Hintergrund Ziel der Studie ist die Überprüfung, ob sich die postoperative Ergebnisqualität und die Komplikationswahrscheinlichkeit hüftendoprothetischer Eingriffe signifikant bei Operateuren in Weiterbildung von denen der sog. Hauptoperateure im Rahmen der EndoCert-Struktur unterscheiden.
Material und Methoden Eingeschlossen wurden 192 Patienten, die mit einer primären Hüftendoprothese versorgt wurden. Zur Evaluierung der Ergebnisqualität wurden präoperativ und 12 Monate postoperativ der Harris-Hip-Score, WOMAC, SF-36 und der EuroQol-5D abgefragt. Zudem wurden als Komplikationen die vom EndoCert-System definierten Qualitätsindikatoren erfasst.
Ergebnisse Signifikante Verbesserungen der postoperativen Score-Werte in Abhängigkeit von der Qualifikation des verantwortlichen Operateurs konnten sowohl bei Senior-/Hauptoperateuren als auch bei Ärzten in Weiterbildung festgestellt werden. Sofern ein Operateur in Facharztweiterbildung von einem Senior-/Hauptoperateur assistiert wird, ist kein Anstieg des peri- und postoperativen Komplikationsrisikos zu verzeichnen. Dagegen ergeben sich signifikante Unterschiede hinsichtlich einer verlängerten OP-Dauer.
Schlussfolgerung Durch die Umsetzung des EndoCert-Verfahrens wird sichergestellt, dass die postoperative Ergebnisqualität und die Komplikationswahrscheinlichkeit nach künstlichem Hüftgelenkersatz nicht von der Qualifikation des Erstoperateurs abhängig sind.
Versorgung von Kindern, Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis
Authors: Minden Kirsten , Niewerth Martina , Klotsche Jens , Zink Angela 
Published: June 2018

Zusammenfassung
Hintergrund Multizentrische Beobachtungsstudien, wie die Kerndokumentation rheumakranker Kinder und Jugendlicher, und bundesweite Abrechnungsdaten vermitteln Informationen zur Versorgung von Kindern, Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis (JIA). Sie gestatten die Art der Versorgung, deren Veränderungen über die Zeit und assoziierte Outcomes sowie Defizite aufzuzeigen.
Methoden Basierend auf Daten der Kerndokumentation, der Umfrage der kinderrheumatologischen Fachgesellschaft zu Versorgungsangeboten in 2017 und Publikationen der letzten Jahre wird die Versorgungssituation bei der JIA zusammenfassend dargestellt. Zur Beurteilung der Krankheitslast wurden neben der in der Kerndokumentation erfassten Krankheitsaktivität (beurteilt anhand des klinischen JADAS-10 [juvenile arthritis disease activity score]) die patienten-berichteten Outcomes Funktionsfähigkeit (bestimmt mittels Childhood Health Assessment Questionnaire) und Schmerzen (erfasst mittels numerischer Ratingskala) herangezogen.
Ergebnisse Für die Behandlung rheumakranker Kinder und Jugendlicher stehen inzwischen bundesweit über 160 Kinder- und Jugendrheumatologen zur Verfügung. Die Versorgung der jungen Patienten erfolgt überwiegend an Krankenhausambulanzen, die Häufigkeit stationärer Behandlungen ist jedoch zurückgegangen. Die medikamentöse Therapie unterlag erheblichen Änderungen, in 2016 wurden 22% aller JIA-Patienten mit Biologika behandelt, von den Patienten mit systemischer JIA sogar fast 40%. Glukokortikoide und NSAR haben mit zunehmendem Biologikaeinsatz an Bedeutung verloren. Die Krankheitslast war bei den Kindern und Jugendlichen mit JIA in den letzten Jahren rückläufig. Sowohl die durchschnittliche Krankheitsaktivität als auch die Funktionseinschränkungen im Alltag sind zurückgegangen, die mittlere Schmerzstärke der Betroffenen änderte sich über die Zeit jedoch nicht relevant. Schätzungsweise mindestens zwei Drittel der JIA-Patienten werden im Kindes- und Jugendalter fachspezifisch versorgt. Im jungen Erwachsenenalter sind es weniger, was Konsequenzen für die medikamentöse Versorgung der Betroffenen hat.
Fazit Mit den heute vorhandenen Versorgungsangeboten und Therapiestrategien lässt sich die Krankheitslast bei den JIA-Patienten erfolgreich reduzieren. Damit Patienten von den neuen Optionen profitieren können, braucht es eine rechtzeitige Erkennung der JIA mit Überweisung und langfristigem Verbleiben in fachspezifischer Betreuung.
Effects of Modified Pyramid System on Muscular Strength and Hypertrophy in Older Women
Authors: dos Santos Leandro , Ribeiro Alex , Cavalcante Edilaine , Nabuco Hellen , Antunes Melissa , Schoenfeld Brad , Cyrino Edilson 
Published: June 2018

AbstractThis study aimed to analyze the effects of a pyramid system performed with two repetition zones on muscular strength and skeletal muscle mass (SMM) in older women. Thirty-nine physically independent older women (67.8±5.4 years) were randomly assigned into one of two of groups that performed an 8-week resistance training program in an ascending pyramid fashion. Both groups performed 3 sets: a narrow repetition zone (NPR, n=20) with 12/10/8 repetitions, and a wide repetition zone (WPR, n=19) with 15/10/5 repetitions. The program consisted of 8 whole-body exercises, performed 3 times a week. Dual-energy X-ray absorptiometry was used to measure SMM, and muscular strength was evaluated by one-repetition maximum (1RM). Both groups increased (P<0.05) SMM (NPR=+ 4.7%, effect size=+ 0.34; WPR=+ 8.4%, effect size=+ 0.77), and total strength (NPR=+ 11.3%, effect size=+ 0.80; WPR=+ 13.8%, effect size=0.84), without statistical differences between them. Results suggest that both zones of repetitions in a pyramid system are effective strategies to improve muscular strength and muscle growth in older women.
Einsparungen bei Behandlungskosten – Kenntnis der Kosten beeinflusst Implantatwahl bei Chirurgen
Authors: Ruchalla Elke 
Published: June 2018

Wasterlain AS. et al. The Effect of Price on Surgeonsʼ Choice of Implants: A Randomized Controlled Survey. J Hand Surg Am 2017; 42: 593–601.e6
Kosteneinsparungen sind heute Thema in allen medizinischen Fachgebieten, sowohl für Ärzte als auch für Kliniken und Krankenversicherer bzw. Patienten selbst.
Weniger klar ist, wie solche Einsparungen vorgenommen werden können, ohne dass die Versorgungsqualität darunter leidet. Bei Unfallchirurgen bzw.
orthopädischen Chirurgen haben das nun Wasterlain et al. untersucht.
Fibrinolytic System in Patients with Hypertensive Cardiovascular Disease
Authors: Prokopowicz J , Worowski K , Popławski A , Gabryelewicz A , Niewiarowski S 
Published: June 2018

SummaryThe fibrinolytic system has been studied in 37 patients with essential hypertension, with arterial hypertension of various etiology (renal hypertension and hypertension with atherosclerosis). It has been found that in all these patients euglobulin fibrinolysis is inhibited and fibrinogen, factor VIII, plasminogen, plasminogen proactivator and antiplasmin increase considerably.On the basis of the above findings and other literature data, the authors present a hypothesis that the fibrinolytic system is involved in the regulation of arterial blood pressure and that the impairment of plasminogen activator production in the renal tissue is one of the contributory factors in the development of arterial hypertension.