bluuebunny/crossref_metadata_2025_split huggingface dataset:
BCR Algorithm for Solving Quadratic Inverse Eigenvalue Problems for Partially Bisymmetric Matrices
Authors: Hajarian Masoud 
Published: December 2018

AbstractThe inverse eigenvalue problem appears repeatedly in a variety of applications. The aim of this paper is to study a quadratic inverse eigenvalue problem of the form AXΛ2 + BXΛ + CX = 0 where A, B and C should be partially bisymmetric under a prescribed submatrix constraint. We derive an efficient matrix method based on the Hestenes‐Stiefel (HS) version of biconjugate residual (BCR) algorithm for solving this constrained quadratic inverse eigenvalue problem. The theoretical results demonstrate that the matrix method solves the constrained quadratic inverse eigenvalue problem within a finite number of iterations in the absence of round‐off errors. Finally we validate the accuracy and efficiency of the matrix method through the numerical results.
Improved recurrent neural networks for online solution of Moore‐Penrose inverse applied to redundant manipulator kinematic control
Authors: Lv Xuanjiao , Tan Zhiguo , Chen Ke , Yang Zhi 
Published: December 2018

AbstractIn this paper, two novel neural networks (NNNs), namely NNN‐L and NNN‐R neural models, are proposed to online left and right Moore‐Penrose inversion. As compared to GNN (gradient neural network) and the recently proposed ZNN (Zhang neural network) for the left or right Moore‐Penrose inverse solving, our models are theoretically proven to possess superior global convergence performance. More importantly, the proposed NNN‐R model is successfully applied to path‐tracking control of a three‐link planar robot manipulator. Illustrative examples well validate the theoretical analyses as well as demonstrate the feasibility of the proposed models, which are adopted and verified their effectiveness in kinematic control of a redundant manipulator, for real‐time Moore‐Penrose inverse solving.
Baubetriebliche und bauwirtschaftliche Potenziale durch Echtzeitmessung der Betonfestigkeit
Authors: Gschösser Florian , Baldauf Phillipp , Tautschnig Arnold , Reinisch Alexander 
Published: December 2018

AbstractDiese Studie untersucht die baubetrieblichen und bauwirtschaftlichen Potenziale der Echtzeitmessung der Festigkeitsentwicklung von Beton für die Herstellung von Stahlbetondecken. Als Modellprojekt wird ein zehnstöckiges Hochhaus untersucht. Im ersten Schritt wird die Anwendung der Echtzeitmessmethodik für eine Ausführungsvariante des Projekts in Scheibenbauweise untersucht. Der starke Einfluss des Verhältnisses der Deckenausschalfristen zur Herstellungsdauer der vertikalen Stahlbetonrohbauelemente auf die Bauzeit veranlasst eine darauffolgende Analyse des Projekts in Skelettbauweise. Die Messung der Betonfestigkeiten bietet für die Scheibenbauweise die Möglichkeit, die Festigkeitsentwicklung über die Betongüte im Verhältnis zur Herstellungsdauer der Wände zu steuern sowie die Vorhaltemenge an Deckenschalungselementen zu halbieren und somit Kosten einzusparen. Sie bietet für die ausgeführte Scheibenbauweise aber nicht die Möglichkeit einer Reduktion der Bauzeit, weil die Deckenausschalfristen den kritischen Weg des Bauablaufs nicht beeinflussen. Jedoch ermöglicht eine Miteinbeziehung der Echtzeitmessung der Betoneigenschaften in den Entwurf der Rohbaustruktur eine Abstimmung der Deckenausschalfristen mit der Herstellungsdauer der vertikalen Tragkonstruktion im Sinne einer Bauzeitverkürzung. Somit kann für die Skelettbauweise zusätzlich zur Reduktion der Vorhaltemengen an Deckenschalelementen eine Reduktion der Gesamtbauzeit erzielt werden.
Demonstration‐scale protein recovery by lactic acid fermentation from grass clover – a single case of the production of protein concentrate and press cake silage for animal feeding trials
Authors: Santamaria‐Fernandez Maria , Ambye‐Jensen Morten , Damborg Vinni K. , Lübeck Mette 
Published: December 2018

AbstractThere is an increasing interest in green biorefineries for the utilization of green biomass to provide a variety of valuable products. Proteins can be extracted from green biomasses such as alfalfa, clover, or grass and separated into protein‐rich concentrates suitable for feeding to monogastric animals. Press cake suitable for feeding ruminant animals is also produced. Full implementation of such a green biorefinery requires knowledge and experience of production at demonstration scale. Moreover, product evaluation in animal‐feeding trials requires a large amount of product. There has been collaboration in Denmark between several partners from industry and academia to assess the practicality and scalability of a green biorefining plant producing protein concentrate and press cake silage from organic grass clover at the scale of ca. 10 tons per hour fresh biomass input. Lactic acid fermentation of the pressed green juice was successfully performed to precipitate proteins and stabilize the juice. Despite minor difficulties, the demonstration‐scale biorefining plant was operative for four days, processed 444 tons of grass clover, and resulted in the overall production of 1 ton of dried protein concentrate, 7 tons of protein paste, and 223 tons of press cake silage. The protein concentrate was rich in essential amino acids and was tested in feeding trials with poultry; the press cake silage, rich in processed fibers and fiber‐associated proteins, was tested in feeding trials with dairy cows. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Maximum likelihood estimation of generalized linear models for adaptive designs: Applications and asymptotics
Authors: Selvaratnam Selvakkadunko , Yi Yanqing , Oyet Alwell 
Published: December 2018

AbstractDue to increasing discoveries of biomarkers and observed diversity among patients, there is growing interest in personalized medicine for the purpose of increasing the well‐being of patients (ethics) and extending human life. In fact, these biomarkers and observed heterogeneity among patients are useful covariates that can be used to achieve the ethical goals of clinical trials and improving the efficiency of statistical inference. Covariate‐adjusted response‐adaptive (CARA) design was developed to use information in such covariates in randomization to maximize the well‐being of participating patients as well as increase the efficiency of statistical inference at the end of a clinical trial. In this paper, we establish conditions for consistency and asymptotic normality of maximum likelihood (ML) estimators of generalized linear models (GLM) for a general class of adaptive designs. We prove that the ML estimators are consistent and asymptotically follow a multivariate Gaussian distribution. The efficiency of the estimators and the performance of response‐adaptive (RA), CARA, and completely randomized (CR) designs are examined based on the well‐being of patients under a logit model with categorical covariates. Results from our simulation studies and application to data from a clinical trial on stroke prevention in atrial fibrillation (SPAF) show that RA designs lead to ethically desirable outcomes as well as higher statistical efficiency compared to CARA designs if there is no treatment by covariate interaction in an ideal model. CARA designs were however more ethical than RA designs when there was significant interaction.
Development of a high‐performance liquid chromatography method with fluorescence detection for the routine quantification of tamoxifen, endoxifen and 4‐hydroxytamoxifen in plasma from breast cancer patients
Authors: Rangel‐Méndez Jorge‐Aarón , Graniel‐Sabido Manlio‐Joaquin , Sánchez‐Cruz Juan‐Francisco , Moo‐Puc Rosa 
Published: December 2018

AbstractTo date, several methods for the quantification of tamoxifen and its metabolites have been developed, most of which employ liquid chromatography tandem–mass spectrometry (LC–MS/MS). These methods are highly sensitive and reproducible, but are also time‐consuming and require expensive equipment; one of their main disadvantages is matrix ionization effects. A more viable option, particularly in developing countries, is high‐performance liquid chromatography coupled with UV or fluorescence detection. We developed and validated a method for simultaneous quantification of tamoxifen, endoxifen and 4‐hydroxytamoxifen based on high‐performance liquid chromatography with fluorescence detection in a reverse‐phase column. The method is rapid (16 min plus 5 min of column re‐equilibrium), accurate (80–100%) and precise (0.23–6.00%), and does not require any additional irradiation process. Sample pretreatment consists of protein precipitation with acetonitrile under alkaline conditions, employing only 200 μL plasma. The validated method's wide range allowed quantification of steady‐state levels in patients under standard tamoxifen treatment (20 mg/day). This assay is ready for application in clinical studies and routine quantification of tamoxifen, endoxifen and 4‐hydroxytamoxifen in healthcare institutions.
Study of pancreatic lipase inhibition kinetics and LC–QTOF–MS‐based identification of bioactive constituents of Momordica charantia fruits
Authors: Chanda Joydeb , Mukherjee Pulok K. , Biswas Rajarshi , Malakar Dipankar , Pillai Manoj 
Published: December 2018

AbstractThe different parts of Momordica charantia have been reported to have several therapeutic applications against hyperglycemia and hypercholesterolemia associated with pancreatic lipase (PL). Inhibition of this enzyme prevents the absorption of dietary triglyceride in the intestine, and thus exerts an anti‐obesity effect. This study aimed to investigate the bioactive constituents of the fruits of M. charantia (MCF) extract and fractions against pancreatic PL followed by study of their inhibition kinetics. The PL inhibitory assay was performed spectrophotometrically by measuring the change in absorbance of the products at 405 nm, using p‐nitrophenylcaprylate as substrate. The results indicated that the ethyl acetate fraction of MCF (EFMC) offered significant, dose‐dependent inhibition against PL, compared with the positive control, Orlistat. The enzyme kinetics study revealed the inhibition to be a mixed type in nature. Additionally, the total phenol and flavonoid content of the fractions was estimated. A positive correlation between phenolic content of EFMC and its PL inhibitory activity was established statistically, which implied that higher inhibition potential was contributed by the phenolic compounds. The identification of the bioactive constituents was further confirmed by LC–QTOF–MS study. This finding suggested that phenolic compounds of MCF can serve as functional food components to address obesity‐related disorders linked with PL.
Synthesis and Biological Evaluation of Substituted Indole and Its Analogs as Influenza A Virus Inhibitors
Authors: Zhang Xuandi , Zhang Guo‐Ning , Wang Yujia , Zhu Mei , Wang Juxian , Li Ziqiang , Li Donghui , Cen Shan , Wang Yucheng 
Published: December 2018

AbstractInfluenza A virus (IAV), a highly pathogenic virus to human beings, is most susceptible to mutation and thus causes rapid, severe global pandemics resulting in millions of fatalities worldwide. Since resistance to the existing anti‐influenza drugs is developing, innovative inhibitors with a different mode of action are urgently needed. The lead compound 6092B‐E5 has proven to be an effective antiviral reagent in our previous work. Using the principles of substitution and bioisosterism of the indole ring, six series of novel anti‐IAV target products were designed, synthesized and evaluated for their antiviral effect in this work. Compounds D1, D3, D9, G1, G3, G12 and G23 were identified as promising anti‐IAV candidates with excellent anti‐IAV efficacy (IC50 values of 3.06–5.77 μm) and low cytotoxicity (CC50 values up to and beyond 100 μm). This work represents a successful application of the substitution and bioisosteric replacement strategy for the discovery of novel antiviral molecules that can be used for further structural optimization.
Early outcome of magnesium bioresorbable scaffold implantation in acute coronary syndrome—the initial report from the Magmaris‐ACS registry
Authors: Wlodarczak Adrian , Lanocha Magdalena , Jastrzebski Artur , Pecherzewski Maciej , Szudrowicz Marek , Jastrzebski Waldemar , Nawrot Joanna , Lesiak Maciej 
Published: December 2018

AbstractObjectivesThe Magmaris‐ACS Registry is the first assessment of the Magmaris implantation in the acute coronary syndrome (ACS) population.BackgroundBioresorbable vascular scaffolds (BRS), the newest coronary stent technology, was developed to overcome the limitations of the metallic drug‐eluting stents (DES). Current promising data of the Magmaris in patients with stable angina have encouraged to validate the second generation BRS in ACS indications.MethodsThe study population consisted of the consecutive patients who underwent PCI with the Magmaris BRS in the settings of ACS. Patients with ST‐segment elevation myocardial infarction were excluded from enrolment. Baseline demographic and angiographic characteristics, as well as 30‐day and 6‐month clinical, follow up were prospectively analyzed.ResultsFifty patients were enrolled at mean age 62.9 ± 8.4 years (unstable angina—52% and non‐ST‐segment myocardial infarction [NSTEMI]—48%). Treated fifty‐one de novo lesions were located in LAD (37%), LCx (14%), and RCA (49%), respectively. Angiographic success in the target lesion was 100%. One case of recurrent ischemia was observed a day after the index procedure, due to the significant distal edge dissection a regular metallic DES overlapping Magmaris was implanted. No other in‐hospital events occurred (procedural success 98%). Six‐Month follow up showed none device‐oriented endpoints such as cardiac mortality, target vessel myocardial infarction or target vessel revascularization. None early scaffold thrombosis was reported.ConclusionThe use of the Magmaris BRS in non‐ST elevation ACS patient is associated with a procedural safety and promising early angiographic and clinical outcomes. Long‐term follow‐up and further evaluation in large prospective randomized controlled trials are needed.
Entwicklung eines Modellansatzes zur Abbildung der Phasendistribution in gepackten Kolonnen
Authors: van Holt Felix , Hapke Mark , Grünewald Marcus 
Published: December 2018

AbstractDie lokale Beschreibung der Phasenverteilung in gepackten Kolonnen bietet einen vielversprechenden Ansatz, um das Scale‐up und die Bestimmung des Kolonnendesigns zu verbessern. Bisherige Ansätze konnten keine technischen Maßstäbe bei gleichzeitig hohen Detaillierungsgraden abbilden. In diesem Beitrag wird ein neuartiges Zellenmodell vorgestellt. Mittels rigoroserer Betrachtung der verteilungsbestimmenden Phänomene und dem Einsatz eines Gittersensors zur Messung der Phasendistribution wird eine verbesserte Extrapolationsfähigkeit des Modells erwartet.
Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries
Authors: Si Yubing , Xu David , Bum‐Erdene Khuchtumur , Ghozayel Mona K. , Yang Baocheng , Clemons Paul A. , Meroueh Samy O. 
Published: December 2018

AbstractThere is growing interest in the use of structure‐based virtual screening to identify small molecules that inhibit challenging protein–protein interactions (PPIs). In this study, we investigated how effectively chemical library members docked at the PPI interface mimic the position of critical side‐chain residues known as “hot spots”. Three compound collections were considered, a commercially available screening collection (ChemDiv), a collection of diversity‐oriented synthesis (DOS) compounds that contains natural‐product‐like small molecules, and a library constructed using established reactions (the “screenable chemical universe based on intuitive data organization”, SCUBIDOO). Three different tight PPIs for which hot‐spot residues have been identified were selected for analysis: uPAR⋅uPA, TEAD4⋅Yap1, and CaVα⋅CaVβ. Analysis of library physicochemical properties was followed by docking to the PPI receptors. A pharmacophore method was used to measure overlap between small‐molecule substituents and hot‐spot side chains. Fragment‐like conformationally restricted small molecules showed better hot‐spot overlap for interfaces with well‐defined pockets such as uPAR⋅uPA, whereas better overlap was observed for more complex DOS compounds in interfaces lacking a well‐defined binding site such as TEAD4⋅Yap1. Virtual screening of conformationally restricted compounds targeting uPAR⋅uPA and TEAD4⋅Yap1 followed by experimental validation reinforce these findings, as the best hits were fragment‐like and had few rotatable bonds for the former, while no hits were identified for the latter. Overall, such studies provide a framework for understanding PPIs in the context of additional chemical matter and new PPI definitions.
Low‐Dimensional Hybrid Perovskites Containing an Organic Cation with an Extended Conjugated System: Tuning the Excitonic Absorption Features
Authors: Van Gompel Wouter T. M. , Herckens Roald , Van Hecke Kristof , Ruttens Bart , D'Haen Jan , Lutsen Laurence , Vanderzande Dirk 
Published: December 2018

AbstractLow‐dimensional hybrid perovskites are receiving increased attention. One of the advantages of the low‐dimensional hybrids over their 3D counterparts is their greater structural flexibility towards the incorporation of bigger, more complex, organic cations. In this communication, we introduce a pyrene derivative as an organic cation containing an extended π‐system for use in a variety of low‐dimensional hybrids. We show that materials with different excitonic absorption features can be obtained by tuning the iodide/lead ratio in the precursor solutions, using the same pyrene cation. In this way, hybrids with optical characteristics corresponding to 2D, 1D and 0D hybrid perovskites are obtained. The formation and thermal stability of the different hybrids is analysed and compared.
Product color emotional design considering color layout
Authors: Ding Man , Dong Wei 
Published: December 2018

AbstractEmotional experience and demand for product colors are important factors in users' decisions to buy and use a product. Therefore, accurately characterizing users' emotional responses of the product's color has become a significant consideration for product color design. However, a product color design problem exists in which it is challenging to accurately and efficiently position users' color image space because consumers have completely different image perceptions when encountering a large number of color schemes generated by different color spatial distributions. For this reason, this article proposes a product color emotional design method that considers the color layout. A table is built of an elemental composition for product color design, which contains color layout forms. This article also establishes a mapping model based on the semantic difference and back propagation neural network between the users' color image perceptions and the elements of the product's color design. The system recommends a color layout form that matches the users' emotional image goal through the k‐nearest neighbor algorithm, and then the form is initialized using a genetic algorithm. The system can realize the solution to the optimal product color scheme by optimizing and evaluating the population. Designers can make intuitive choices and decisions through the product color recommendation system. Through an example of color design for industrial vacuum cleaners, this article shows that the method has satisfactory feasibility and applicability for solving the problem of the optimization of product color design with color layout forms.
Spin‐Crossover Assisted Spin‐Switching and Rectification Action in Half‐Metallic Graphitic Carbon Nitride(g‐C4N3)
Authors: Bhowmick Rinki , Sen Sabyasachi 
Published: December 2018

AbstractHerein, we report on the potential multifunctional spintronic action of half‐metallic graphitic carbon nitride (g‐C4N3). We observed electrostatic spin‐crossover action at an applied electric field of −0.77 V nm−1, which eventually leads to spin‐switching action and change in sign of bias dependent spin injection coefficient. The system also acts as a spin polarized charge current rectifier with rectification ratio of 65.41 in spin‐up channel only. This electric field‐controlled spin switching action and simultaneous existence of rectification action makes graphitic carbon nitride a perfect multifunctional spintronic system‐an ideal material for quantum logic gate design. Results obtained have been substantiated through transmission spectra and transmission pathways analyses. An analysis of projected device density of states of the system and molecular projected self consistent Hamiltonian states analysis reveals that the electron flow of the system is mainly facilitated by 2p orbitals of C and N atoms.
Bimetallic Metal Organic Frameworks as Magnetically Separable Heterogeneous Catalysts and Photocatalytic Dye Degradation
Authors: Tiwari Ashish , Sagara Prateep Singh , Varma Vicky , Randhawa Jaspreet Kaur 
Published: December 2018

AbstractA new bimetallic MOF (BMOF) has been synthesized using iron and zinc as inorganic metal nodes and 1,4‐benzenedicarboxylic acid (BDC) as the organic linker molecule. BMOF was confirmed by single‐crystal X‐ray diffraction (SCXRD), X‐ray photoelectron spectroscopy (XPS), transmission electron microscopy high‐angle annular dark‐field imaging (TEM‐HAADF), field emission scanning electron microscopy energy‐dispersive X‐ray analysis (FESEM‐EDX), vibrating sample magnetometry (VSM) and inductively coupled plasma mass spectrometry (ICP‐MS) analysis. The synthesized BMOF shows excellent optical and magnetic properties. BMOF acts as a heterogeneous catalyst and shows high catalytic activity towards bis(indolyl)methane synthesis and photocatalytic degradation of methylene blue (MB) under visible‐light illumination.
Differential regulation of intestinal and hepatic CYP3A by 1α,25‐dihydroxyvitamin D3: Effects on in vivo oral absorption and disposition of buspirone in rats
Authors: Maeng Han‐Joo , Doan Trang Nguyen Kieu , Yoon In‐Soo 
Published: December 2018

Abstract1α,25‐Dihydroxyvitamin D3 (also called 1,25(OH)2D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH)2D3‐mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH)2D3 treatment on CYP3A‐mediated drug metabolism and pharmacokinetics. Here, we report the effects of 1,25(OH)2D3 on CYP3A activity and in vivo pharmacokinetics of buspirone in Sprague–Dawley rats. CYP3A mRNA expression and CYP3A‐mediated testosterone metabolism were enhanced in the intestine but were unaffected in the livers of rats treated with 1,25(OH)2D3. Notably, the oral pharmacokinetic profile of buspirone (CYP3A substrate drug) and 6′‐hydroxybuspirone (major active metabolite of buspirone formed via CYP3A‐mediated metabolism) was significantly altered, while its intravenous pharmacokinetic profile was not affected by 1,25(OH)2D3 treatment. To the best of our knowledge, this study provides the first reported data regarding the effects of 1,25(OH)2D3 treatment on the in vivo pharmacokinetics of intravenous and oral buspirone in rats, by the differential modulation of hepatic and intestinal CYP3A activity. Our present results could lead to further studies in clinically significant CYP3A‐mediated drug–nutrient interactions with 1,25(OH)2D3, including 1,25(OH)2D3–buspirone interaction.

Preclinical Research & Development