bluuebunny/crossref_metadata_2025_split huggingface dataset:
17. Angiolymphoid hyperplasia with eosinophilia mimicking temporal arteritis
Authors: Ansari Ghazal , Pakozdi Angela , Etomi Oseme 
Published: September 2019

Abstract

Introduction
A 32-year-old man presented to rheumatology clinic with a 2-year history of progressively worsening right temporal headache, a painful hard lump on his right temple and pre-auricular tenderness not responding to conventional analgesics. Patient denied any jaw and tongue claudication. His vision was not compromised and patient denied weight loss, night sweats and arthralgia. He was fit and well otherwise.

Case description
Examination revealed a pulsatile mass with a length of 1 cm along the superficial temporal artery. Temporal artery ultrasound revealed lump corresponds to the superficial artery with thickened wall and halo formation raising the possibility of temporal arteritis. MRI head scan suggested inflammation of the superficial temporal artery.

Discussion
Because of the atypical features of young age and normal inflammatory markers, corticosteroid treatment was not commenced. A temporal artery biopsy showed no evidence of vasculitis, but revealed reactive lymphoid follicles with eosinophil infiltrates in the surrounding soft tissue. The diagnosis of angiolymphoid hyperplasia with eosinophilia (ALHE) was made. The patient’s headaches have completely resolved after the temporal biopsy. Unfortunately, three months later the lump and the headaches recurred. The symptoms improved with topical tacrolimus 0.1% ointment and he underwent for complete surgical excision of the lump. Patient is asymptomatic and remained well.

Key learning points
We present a case of angiolymphoid hyperplasia with eosinophilia which can mimic temporal arteritis presentation as in our case and has totally different approach to management. ALHE, which is a benign, locally proliferative condition with predilection to the periauricular and scalp area with no definitive treatment however, complete excision can be curative. It may recur in up to one-third of cases in the absence of complete surgical excision as in our patient.

Conflict of interest
The authors declare no conflicts of interest.
3. Dermatomyositis and underlying bilateral benign endometrioma
Authors: Parker Lucy , Soliotis Fotini 
Published: September 2019

Abstract

Introduction
The link between ovarian malignancy and paraneoplastic dermatomyositis is well established. Association with underlying benign ovarian pathology is much less certain, with only scarce case report evidence available. This represents the first case of dermatomyositis with associated bilateral ovarian chocolate cysts.

Case description
A 45-year-old female presented with classical features of dermatomyositis, with a background of hypertension and non-alcoholic fatty liver disease. She had proximal limb weakness, neck flexor weakness, dysphagia and dysphonia, accompanied by a scaly, erythematous rash over her face, chest, abdomen and lateral thighs. Serum creatine kinase (CK) at presentation was 4923 IU/L. An MRI scan of her thighs showed widespread muscle oedema affecting both legs and the pelvis, including the quadriceps, iliacus and psoas muscles. A punch biopsy of the skin on her thigh showed only post inflammatory pigmentation. Lung volumes were reduced (FEV1 69% predicted). Video fluoroscopy confirmed moderate-severe pharyngeal stage dysphagia. CT scan of the chest, abdomen and pelvis revealed enlarged, unilocular cysts in each ovary, the right cyst measuring 7 cm and the left, 5 cm in maximal diameter. Subsequent transvaginal ultrasound confirmed bilateral unilocular, thick walled cysts with a ground-glass appearance, which would be consistent with benign endometriomas. A further interval ultrasound after 1 month showed no change in their appearance or size. Serum CA125 was 104 kU/L.
The patient was treated with 3 pulses of 1g intravenous (IV) methylprednisolone, followed by 2 courses of IV immunoglobulin 2g/kg over 5 days. This was followed by a gradually reducing course of oral prednisolone, starting at 50mg OD PO alongside 15mg weekly of oral methotrexate. She has responded well to treatment, with near normalisation of her objective manual muscle testing scores and normalisation of the serum CK value. Surgery is now planned for a total abdominal hysterectomy and bilateral oophorectomy.

Discussion
Extensive investigation has not demonstrated any other underlying malignancy to account for the development of dermatomyositis. Initial limited and unsustained clinical response to IV methylprednisolone prompted further treatment with IV immunoglobulin. Surgical histology results are now awaited to confirm the suspected diagnosis. It will be very interesting to see if surgical removal of the cysts has any impact on the clinical manifestation of disease.

Key learning points
Benign ovarian pathology should not be dismissed as a potential underlying mechanism for development of dermatomyositis.

Conflicts of interest
The authors have declared no conflicts of interest.
Social jetlag is associated with an increased likelihood of having depressive symptoms among the Japanese working population: the Furukawa Nutrition and Health Study
Authors: Islam Zobida , Hu Huanhuan , Akter Shamima , Kuwahara Keisuke , Kochi Takeshi , Eguchi Masafumi , Kurotani Kayo , Nanri Akiko , Kabe Isamu , Mizoue Tetsuya 
Published: September 2019

Abstract

Study Objectives
Social jetlag, a mismatch between biological and social timing, has been reported to be associated with depressive symptoms among general population. However, evidence on this association is lacking among non-shift workers, who are under pressure to adapt themselves to a work schedule. We investigated the cross-sectional association of social jetlag with depressive symptoms among Japanese non-shift workers.

Methods
This study included 1,404 employees, aged 18–78 years, who completed a study questionnaire at a periodic health checkup. Social jetlag was calculated as the absolute value of the difference in the midpoint of sleep times between weekdays and weekends. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Multivariable logistic regression was used to estimate the odds ratio (OR) with adjustments for potential confounders including diet and chronotype.

Results
Of the study participants, 63.5%, 28.4%, and 8.1% had less than 1 hour, 1 to less than 2 hours, and at least 2 hours of social jetlag, respectively. Greater social jetlag was significantly associated with an increased likelihood of having depressive symptoms. The multivariable-adjusted OR (95% confidence interval) were 1.30 (0.95 to 1.78) and 2.14 (1.26–3.62) for 1 to less than 2 hour and at least 2 hours compared to less than 1 hour of social jetlag. The association between social jetlag and depressive symptoms appeared to be linear, according to restricted cubic spline regression.

Conclusion
Results suggest that greater social jetlag is associated with an increased likelihood of having depressive symptoms among non-shift workers.
The Automated and Electric Vehicles Act 2018 Part 1 and Beyond: A Critical Review
Authors: Marson James , Ferris Katy , Dickinson Jill 
Published: September 2019

Abstract
On 19 July 2018, the Automated and Electric Vehicles Act 2018 (AEVA) received Royal Assent. As motor vehicles are becoming increasingly technologically based, with driving aids having taken over many of the more mundane (and possibly dangerous) aspects of driving from the driver, it is imperative that legislation keeps pace to determine the responsibilities of the parties. Motor insurance provides protection for those involved with vehicles and who may suffer harm, injury, and loss due to the negligence of the actors. This is most frequently driver error, but may also include manufacturing defects, which result in deaths and less serious injuries. It is also here where the intersection between torts and insurance laws needs careful management. It would be particularly unfair to ask drivers or third-party victims of motor vehicle accidents to seek redress from a manufacturer for losses incurred during the actions of an autonomous vehicle. Consumer law has historically removed this burden from affected consumers and it is entirely sensible for the law to protect individuals in an emerging field—and perhaps even more so given the trajectory of vehicles with driver-enabled qualities and the numbers of vehicles currently featuring such innovations. Yet, the AEVA consists of aspects which are troubling in respect of the motor insurance industry’s dominance of this market, the application of compulsory insurance, and exclusions and limitations to responsibility which expose policy holders and victims to EU-breaching levels of risk.
Social Support, Quality of Services, and Job Satisfaction: Empirical Evidence from Palestinian Social Workers
Authors: Safadi Najwa Sado 
Published: September 2019

Abstract
This study examines the predictors of job satisfaction among public sector social workers in occupied Palestinian territories. Using a quantitative design, data were collected in summer of 2016 through a paper-based, self-administered questionnaire (N = 237). Using hierarchical multiple regression, the three models explained 15 percent to 32 percent of the variance in job satisfaction. In the final model, coefficient indicated that monthly income, contract work status, service orientation, and supervisory support are related to job satisfaction. Respondents with more children and lower salaries showed lower levels of job satisfaction. Respondents who are working as temporary contract workers, who have positive attitudes toward the social work profession, and who have positive attitudes toward supervisory support are more likely to be satisfied with their job. Implications for administrative practice and policy are presented.
I–2 Systemic Effect of LIPUS on B-TCP-(tri-calcium-phosphate) Ceramic Discs Subcutaneously Implanted in the Dorsal Aspect of Rat
Authors: Hidaka Kouki , Mikuni-Takagaki Yuko , Fujita Maiko , Seki Azusa , Ito Yoshihiro , Kumagai Ken , Takeuchi Ryohei 
Published: September 2019

Objective:
It is essential to have sufficient numbers of cells for bone regeneration. We previously reported that LIPUS exposure to rodent fractured femurs or sockets of extracted teeth recruited cells from sites remote to the lesion through peripheral blood vessels (Kumagai, Takeuchi et al, J Orthop Res 2012 and Hidaka et al, Int J Anal Bio-Sci 2015). In the present study, we tried to show LIPUS exerted its anabolic action systemically on tricalcium phosphate (β-TCP) discs implanted in the back of rats, which were not directly treated with LIPUS.

Materials and Methods:
Four pairs of male Sprague Dawley rats were operated on as previously described. A week later, 3 β-TCP discs were implanted in the dorsal aspect of sham operated control rats and the experimental rats. On and following the day of implantation, the 2 discs closer to the rat head only in one of the pair were exposed to LIPUS every 24 hours for 2 weeks as described.

Results and Discussion:
Except in one rat, which showed enlarged spleen and adrenal body, no abnormality was found. Body weight, histology, and transfer of injected fluorescence-conjugated protein from one to the other rat suggested the operation was successful. In the β-TCP discs of LIPUS-untreated side rats, we observed invaded cells and blood vessels present in numbers between those of the LIPUS-exposed and the control rats. Real-time PCR and immunohistochemistry analysis also showed consistent results. Given these findings, the systemic effect of LIPUS may be more influential than we used to assume.
II–1 Compliance With Treatment Using Low-Intensity Pulsed Ultrasound (LIPUS): Comparison Between Fresh Fracture and Delayed Union Groups
Authors: Nakajima Daisuke , Uchiyama Yoshiyasu , Kobayashi Yuka , Watanabe Masahiko 
Published: September 2019

Objective:
Since treatment with low-intensity pulsed ultrasound (LIPUS) is performed by patients themselves, patient's compliance with the treatment may be a problem. In this study, we investigated the differences in patients compliance to LIPUS due to differences in the timing of the introduction of LIPUS (fresh fracture group vs. delayed union group).

Subjects and Methods:
Of 367 patients who used LIPUS at 3 Tokai University Hospitals between May 2010 and November 2017, 283 patients (male: 186, female: 97) who were able to be followed until completion of the LIPUS treatment were selected as the subjects. The patients were divided into 2 groups: a fresh fracture group (159 patients) in which LIPUS was introduced within 3 months after the injury and a delayed union group (124 patients) in which LIPUS was introduced 3 months or later after the injury. The compliance rate (the number of days using LIPUS/number of days on which the device was lent × 100), duration of LIPUS use, and pseudarthrosis formation rate were evaluated as indices of the patients' compliance to LIPUS treatment. For statistical comparisons of the 2 groups, χ2 test or Mann–Whitney U-test were used and P-values < 0.05 were regarded as significant.

Results:
The LIPUS compliance rates were 67.7 ± 20.1 and 69.8 ± 21.0% in the fresh fracture and delayed union groups, respectively, showing no significant difference. The durations of LIPUS use were 130 ± 64 and 161 ± 86 days, respectively, showing that it was used for a more prolonged duration in the latter group (P = 0.004). The pseudarthrosis formation rates were 5.0% (8 cases) and 5.6% (7 cases), respectively, showing no significant difference between the 2 groups.

Discussion:
The relationships between low LIPUS compliance rate, prolongation of the duration of use and lower patient age have been reported previously. However, this study clarified that the duration of LIPUS use was also extended as the introduction of LIPUS was delayed. However, the pseudarthrosis formation rate did not increase in the delayed union group and had no major influence on compliance.
Camps for Children with Cancer and Their Families: A Systematic Review of Psychosocial and Physical Impacts
Authors: Kelada Lauren , Wakefield Claire Elizabeth , Cruz Silva Maria C. , Signorelli Christina 
Published: September 2019

ABSTRACT:Objective:Camps for children with cancer and their families aim to promote positive psychosocial and physical outcomes for attendees. However, evidence for this is inconsistent, and previous reviews have not delineated between camps for children (patient/survivors and siblings) and family camps (including parents/guardians). Such understanding is necessary to understand the evidence-based benefits of each type of camp. Our systematic review summarizes the findings and limitations of the recent literature for children's camps and family camps.Methods:We searched MEDLINE/PubMed, PsycINFO, Social Work Abstracts, and Google Scholar for relevant articles published between 2013 and 2018.Results:Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol, we included 19 articles (from 15 studies) in the review. Evidence for the impact of camps was mixed. All articles reported positive outcomes, yet 3 quantitative articles also reported nonsignificant changes. Camps for children (representing 2151 children with cancer/survivors) appeared to facilitate social skills, self-esteem, and physical activity. Family camps (representing 96 families) may provide families the opportunity to reconnect. Both types of camp provide attendees with social support and fun/respite. In 2 qualitative articles, some parents attending family camps reported tension between families of children on treatment and bereaved families. The literature is limited by small sample sizes and the lack of multisite, longitudinal, and controlled study designs.Conclusion:The recent literature provides evidence for some positive, short-term psychosocial and physical outcomes of camps. Future research should use rigorous quasiexperimental designs and should assess the long-term impact of camp attendance.
Profiles and Predictors of Infant Sleep Problems Across the First Year
Authors: Cook Fallon , Conway Laura , Gartland Deirdre , Giallo Rebecca , Keys Elizabeth , Brown Stephanie 
Published: September 2019

ABSTRACT:

Objective:
To identify profiles and predictors of maternal-reported infant sleep problems across the first postnatal year.

Methods:
Survey data examining maternal mental and physical health, intimate partner violence (IPV), and infant sleep problems and night waking were gathered from a cohort of 1,460 nulliparous women at 15 weeks' gestation and when their infants were 3, 6, 9, and 12 months old.

Results:
Latent class analysis revealed 5 profiles of infant sleep problems, including those who had few problems (24.7%), persistent moderate problems (27.3%), increased problems at 6 months (10.8%), increased problems at 9 months (17.8%), and persistent severe problems (19.4%). Persistent severe infant sleep problems were associated with prepartum and postpartum maternal depression (adjusted odds ratio [AOR] 2.13, 95% confidence interval [CI] 1.35–3.34, p < 0.01; AOR 2.52, 95% CI 1.64–3.87, p < 0.001, respectively), poorer prepartum and postpartum perception of health (adjusted mean difference [AMD] 23.48, 95% CI 24.9 to 22.1, p < 0.01; AMD 23.78, 95% CI 25.2 to 22.4, p < 0.001, respectively), increased postpartum anxiety (AOR 2.22, 95% CI 1.26–3.90, p < 0.01), and increased prevalence of IPV in the first year postpartum (AOR 1.86, 95% CI 1.20–2.87, p < 0.01).

Conclusion:
Poorer prepartum and postpartum maternal mental and physical health, and IPV, were associated with maternal report of persistent severe infant sleep problems. Women experiencing prenatal physical and mental health difficulties may benefit from advice on managing infant sleep and settling. Health professionals working with unsettled infants must be equipped to enquire about and respond appropriately to disclosures of IPV.
Simulation in Cleft Surgery
Authors: Kantar Rami S. , Alfonso Allyson R. , Ramly Elie P. , Diaz-Siso J. Rodrigo , Breugem Corstiaan C. , Flores Roberto L. 
Published: September 2019

Background:
A number of digital and haptic simulators have been developed to address challenges facing cleft surgery education. However, to date, a comprehensive review of available simulators has yet to be performed. Our goal is to appraise cleft surgery simulators that have been described to date, their role within a simulation-based educational strategy, the costs associated with their use, and data supporting or refuting their utility.

Methods:
The following PubMed literature search strategies were used: “Cleft AND Simulation,” “Cleft Surgery AND Simulation,” “Cleft Lip AND Simulation,” “Cleft Palate AND Simulation.” Only English language articles up to May 1, 2019, were included. Simulation phases of learning were classified based on our previously proposed model for simulation training.

Results:
A total of 22 articles were included in this study. Within identified articles, 11 (50%) were strictly descriptive of simulator features, whereas the remaining 11 (50%) evaluated specific outcomes pertinent to the use of cleft surgery simulators. The 22 included articles described 16 cleft surgery simulators. Out of these 16 cleft surgery simulators, 7 (43.8%) were high fidelity haptic simulators, 5 (31.2%) were low fidelity haptic simulators, and 4 (25.0%) were digital simulators. The cost to simulator user ranged from freely available up to $300.

Conclusions:
Cleft surgery simulators vary considerably in their features, purpose, cost, availability, and scientific evidence in support of their use. Future multi-institutional collaborative initiatives should focus on demonstrating the efficacy of current cleft simulators and developing standardized assessment scales.
Donor Site Morbidity in Phalloplasty Reconstructions: Outcomes of the Radial Forearm Free Flap
Authors: Kovar Alexandra , Choi Susie , Iorio Matthew L. 
Published: September 2019

Background:
The radial artery forearm free flap (RFFF) is the workhorse technique for phallus reconstruction. The RFFF provides good cosmesis and potential sensory recovery. However, the donor site is large in comparison to other applications of the RFFF which may increase the potential for donor site morbidity, such as nerve injury, delayed wound healing, and decreased hand strength. This study systematically reviewed the current literature to assess the donor site morbidity associated with RFFF phalloplasty (RFFFP).

Methods:
A systematic review utilizing Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines was completed of the current literature pertaining to donor site morbidity after RFFFP. Two investigators independently reviewed the literature to determine eligibility for inclusion. Two hundred sixty-seven studies were reviewed and 10 were included in the final analysis after application of exclusion criteria.

Results:
Nine hundred forty flap reconstructions were identified. Gender affirming surgery was the indication in 77.7% (n = 730) of patients. The overall donor site complication rate was 7.9% (n = 74). Skin graft failure occurred in 41 patients (4.5%) and was the most frequent complication. Donor site infection (n = 3, 15.8%), hematoma (n = 1, 0.8%), neuroma (n = 1, 10%), compartment syndrome (n = 1, 0.8%), decreased strength or sensation (n = 15, 4.9%), lymphedema or limb swelling (n = 10, 3.9%), and contracture (n = 2, 6.5%) were also found.

Conclusions:
The most common donor site complication after RFFFP is skin graft failure. Decreased forearm sensation and strength affected a significant proportion of patients within each reported cohort. Prospective studies should continue to evaluate donor site morbidity with objective measures, such as grip strength evaluation, and long-term follow-up for vascular changes following radial artery harvest.
A Novel Mangled Upper Extremity Injury Assessment Score
Authors: Savetsky Ira L. , Aschen Seth Z. , Salibian Ara A. , Howard Katherine , Lee Z-Hye , Frangos Spiros G. , Thanik Vishal D. 
Published: September 2019

Background:
Managing mangled upper extremity injuries is a challenging problem because multiple tissue components including soft tissue, muscle, tendon, bone, nerves, and vessels are involved. The complexity of these injuries has hindered the development of accurate scoring systems and treatment algorithms.

Methods:
Patients with mangled upper extremities presenting to a metropolitan level 1 trauma center in New York City over a 10-year period were identified. A mangled upper extremity was defined as any injury to ≥3 tissue components involving the extremity proximal to the digit.

Results:
The injuries and outcomes of 76 patients were evaluated and used to create a Mangled Upper Extremity Score (MUES). One point was assigned for each of the following injury characteristics: patient age >40, fasciotomy needed, bony fixation required, bony defect present, revascularization required, crush injury mechanism, degloving or avulsion injury present, and a soft tissue defect >50 cm2. The MUES correlated with the number of complications (P value = 1.96 × 10−7) and length of hospital stay (P value = 3.95 × 10−7). Next, a Mangled Extremity Severity Score (MESS) equivalent was calculated for each patient. There was no correlation between the MESS and the number of complications (P value = 0.92) or length of hospital stay (P value = 0.35).

Conclusions:
Existing extremity scoring systems, including the MESS, are not reliable in predicting the success of limb salvage attempts or outcomes of mangled upper extremity injuries. The MUES developed in this study correlates significantly with important outcome measures including the number of hospital complications and length of hospital stay.