bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction
Authors: Chi Ani , Yang Chao , Liu Jie , Zhai Zhichen , Shi Xuetao 
Published: November 2024

AbstractTherapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging males. However, the outcomes of these therapies are not satisfactory. In this study, it is demonstrated that the aging microenvironment of the testicular interstitium impairs the function of SLCs, leading to poor regeneration of LCs and, consequently, inefficient functional restoration. The study develops a decellularized testicular extracellular matrix (dTECM) hydrogel from young pigs and evaluates its safety and feasibility as a supportive niche for the expansion and differentiation of SLCs. dTECM hydrogel facilitates the steroidogenic differentiation of SLCs into LCs, the primary producers of testosterone. The combination of SLCs with a dTECM hydrogel leads to a significant and sustained increase in testosterone levels, which promotes the restoration of spermatogenesis and fertility in an LC‐deficient and aged mouse model. Mechanistically, collagen 1 within the dTECM is identified as a key factor contributing to these effects. Notably, symptoms associated with testosterone deficiency syndrome are significantly alleviated in aged mice. These findings may aid the design of therapeutic interventions for patients with testosterone deficiency in the clinic.
Isolated Rhodium Atoms Activate Porous TiO2 for Enhanced Electrocatalytic Conversion of Nitrate to Ammonia
Authors: Zhao Zhi Liang , Yang Shaoxuan , Wang Shensong , Zhang Zhe , Zhao Liang , Wang Qi , Zhang Xinyi 
Published: November 2024

AbstractThe direct electrochemical reduction of nitrate to ammonia is an efficient and environmentally friendly technology, however, developing electrocatalysts with high activity and selectivity remains a great challenge. Single‐atom catalysts demonstrate unique properties and exceptional performance across a range of catalytic reactions, especially those that encompass multi‐step processes. Herein, a straightforward and cost‐effective approach is introduced for synthesizing single‐atom dispersed Rh on porous TiO2 spheres (Rh1‐TiO2), which functions as an efficient electrocatalyst for the electroreduction of NO3− to NH3. The synthesized Rh1‐TiO2 catalyst achieve a maximum NH3 Faradaic efficiency (FE) of 94.7% and an NH3 yield rate of 29.98 mg h−1 mgcat−1 at −0.5 V versus RHE in a 0.1 M KOH+0.1 M KNO3 electrolyte, significantly outperforming not only undoped TiO2 but also Ru, Pd, and Ir single‐atom doped titania catalysts. Density functional theory calculations reveal that the incorporation of Rh single atom significantly enhances charge transfer between adsorbed NO3− and the active site. The Rh atoms not only serve as the highly active site for electrochemical nitrate reduction reaction (NO3RR), but also activates the adjacent Ti sites through optimizating the electronic structure, thereby reducing the energy barrier of the rate‐limiting step. Consequently, this results in a substantial enhancement in electrochemical NO3RR performance. Furthermore, this synthetic method has the potential to be extended to other single‐atom catalysts and scaled up for commercial applications.
Optimizing Reversible Phase‐Transformation of FeS2 Anode via Atomic‐Interface Engineering Toward Fast‐Charging Sodium Storage: Theoretical Predication and Experimental Validation
Authors: Zhao Wenxi , Zhou Yanbing , Zhou Hao , Wang Xinqin , Sun Shengjun , He Xun , Luo Yongsong , Ying Binwu , Yao Yongchao , Ma Xiaoqing , Sun Xuping 
Published: November 2024

AbstractSodium‐storage performance of pyrite FeS2 is greatly improved by constructing various FeS2‐based nanostructures to optimize its ion‐transport kinetics and structural stability. However, less attention has been paid to rapid capacity degradation and electrode failure caused by the irreversible phase‐transition of intermediate NaxFeS2 to FeS2 and polysulfides dissolution upon cycling. Under the guidance of theoretical calculations, coupling FeS2 nanoparticles with honeycomb‐like nitrogen‐doped carbon (NC) nanosheet supported single‐atom manganese (SAs Mn) catalyst (FeS2/SAs Mn@NC) via atomic‐interface engineering is proposed to address above challenge. Systematic electrochemical analyses and theoretical results unveil that the functional integration of such two type components can significantly enhance ionic conductivity, accelerate charge transfer efficiency, and improve Na+‐adsorption capability. Particularly, SAs Mn@NC with Mn‐Nx coordination center can reduce the decomposition barrier of Na2S and NaxFeS2 to further accelerate reversible phase transformation of Fe/Na2S→NaFeS2→FeS2 and polysulfides decomposition. As predicted, such FeS2/SAs Mn@NC showcases outstanding rate capability and fascinating cyclic durability. A sequence of kinetic studies and ex situ characterizations provide the comprehensive understanding for ion‐transport kinetics and phase‐transformation process. Its practical use is further demonstrated in sodium‐ion full cell and capacitor with impressive electrochemical capability and excellent energy‐density output.
Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays
Authors: Zhang Guannan , Li Zehao , Sun Menlin , Lu Ying , Song Jianbo , Duan Wangping , Huang Xiaobo , Hang Ruiqiang , Yao Xiaohong , Chu Paul K , Zhang Xiangyu 
Published: November 2024

AbstractThe physical killing of bacteria based on surface topography has attracted much attention due to the sustainable and safe prevention of biofilm formation. However, the antibacterial efficiency of biomedical implants derived solely from nanostructures or microstructures is insufficient to combat bacteria against common infections, such as methicillin‐resistant Staphylococcus aureus with thick cell walls. Herein, photothermal therapy is carried out in the presence of nanorod arrays to mitigate infection of biomedical implants. Different from traditional photothermal therapy relying on a photosensitizer, the photothermal effect is mediated by light traps rendered by the nanorod arrays, and consequently, the photosensitizer is not needed. Finite element simulations and experiments are performed to elucidate the light‐to‐thermal conversion mechanism. This photothermal platform, in conjunction with thermosensitive nitric oxide therapy, is applied to treat titanium implant infection. The nanostructure‐mediated photothermal effect destroys bacterial cell walls by inhibiting peptidoglycan synthesis and increasing the membrane permeability by affecting fatty acid synthesis. Furthermore, the nanorods synergistically puncture the bacterial membrane easily as demonstrated by experiments and transcriptome analysis. The results provide insights into the development of efficient antibacterial treatment of implants by combining nanostructures and photothermal therapy.
Manganese(I)‐Catalyzed Access to Enantioenriched Chiral Aziridine Phosphines
Authors: Ni Chuang , Ramspoth Tizian‐Frank , Reis Marta Castiñeira , Harutyunyan Syuzanna R. 
Published: November 2024

AbstractHerein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2H‐azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core – a structural motif recognized for its antitumor and antibacterial properties – but also introduces a phosphine moiety alongside the generation of an NH moiety within a strained three‐membered ring. The discovery of this new Mn(I) complex that both enables the reaction and induces stereoselectivity is pivotal, as it underscores the significant potential of this earth‐abundant metal in advancing asymmetric catalysis.
Metal‐Phthalocyanine‐Based Two‐Dimensional Conjugated Metal‐Organic Frameworks for Electrochemical Glycerol Oxidation Reaction
Authors: Huang Xing , Wang Mingchao , Zhong Haixia , Li Xiaodong , Wang Huaping , Lu Yang , Zhang Geping , Liu Yannan , Zhang Panpan , Zou Ruqiang , Feng Xinliang , Dong Renhao 
Published: November 2024

AbstractElectrochemical glycerol oxidation reaction (GOR) is a promising candidate to couple with cathodic reaction, like hydrogen evolution reaction, to produce high‐value product with less energy consumption. Two dimensional conjugated metal–organic frameworks (2D c‐MOFs), comprising square‐planar metal‐coordination motifs (e.g., MO4, M(NH)4, MS4), are notable for their programable active sites, intrinsic charge transport, and excellent stability, making them promising catalyst candidates for GOR. In this study, we introduce a novel class of 2D c‐MOFs electrocatalysts, M2[NiPcS8] (M=Co/Ni/Cu), which are synthesized via coordination of octathiolphthalocyaninato nickel (NiPc(SH)8) with various metal centers. Due to a fast kinetic and high activity of CoS4 sites for GOR, the electrocatalytic tests demonstrate that Co2[NiPcS8] supported on carbon paper displays a low GOR potential of 1.35 V vs. RHE at 10 mA cm−2, significantly reducing the overall water‐electrolysis‐voltage reduction by 0.27 V from oxygen evolution reaction to GOR, thereby outperforming Ni2[NiPcS8] and Cu2[NiPcS8]. Additionally, we have determined that the GOR activity of CoX4 linkage sites varies with different heteroatoms, following an experimentally and theoretically confirmed activity order of CoS4>CoO4>Co(NH)4. The GOR performance of Co2[NiPcS8] not only demonstrate superior performance among non‐noble metal complex, but also provides critical insights on designing high‐performance MOF electrocatalysts upon optimizing the electronic environment of active sites.
Freestanding Phosphonium Covalent Organic Frameworks with Efficient Hydroxide Conduction for Zinc–Air Batteries
Authors: Tian Ye , Hui Xiaobin , Wang Kaiyu , Yuan Yufei , Chen Huanhuan , Bang Ki‐Taek , Tao Ran , Wang Rui , Shin Dong‐Myeong , Lan Yaozhong , Xu Zheng‐Long , Kim Yoonseob 
Published: November 2024

AbstractOwing to their well‐defined crystalline pore structures and ordered functional ionic groups along the skeleton, ionic covalent organic frameworks (iCOFs) exhibit excellent performance and have significant potential for use in energy storage and conversion devices. Herein, we for the first time developed cationic phosphonium COFs with high hydroxide conduction even with low ion exchange capacity (IEC). Specifically, we synthesized COFs containing quaternary phosphonium groups as excellent ion transport moieties. Then, we fabricated freestanding phosphonium membranes through a vapor‐assisted method, which exhibited high hydroxide conductivity of 126 mS cm−1 at 80 °C from a minimal IEC of 1.17 mmol g−1. The resulting film was successfully applied to zinc–air batteries, demonstrating energy density of 96.1 mW cm−2, specific capacity of 95.0 mAh cm−2, and stable operation over 2,300 min. Overall, in addition to investigating a novel cationic functional group, we demonstrated a freestanding film formation method of COF‐based materials. The findings can provide a solid foundation for advancing the field of iCOFs to ion transport and promoting electrochemical applications.
Copper(I)‐Catalyzed Asymmetric 1,4‐Hydroarsination of α,β‐Unsaturated Compounds
Authors: Xiao Jun‐Zhao , Cai Zhen‐Xi , Pan Zhi‐Zhou , Wang Ye , Jiang Nan , Yin Liang 
Published: November 2024

AbstractHerein, a copper(I)‐catalyzed asymmetric 1,4‐hydroarsination of β‐substituted α,β‐unsaturated esters is achieved in moderate to excellent yields with high to excellent enantioselectivity, based on the proposed nucleophilic [Cu]−AsPh2 species. As for α‐substituted α,β‐unsaturated esters, a 1,4‐hydroarsination/enantioselective protonation event occurs smoothly in satisfying results. Furthermore, β‐substituted α,β‐unsaturated ketone, α,β‐unsaturated amide, and α,β‐unsaturated phosphine sulfide are well applied in the present catalytic system. Finally, some control experiments show that HAsPh2 is activated through coordination with the copper(I) catalyst and HAsPh2 exhibits inferior soft Lewis basicity to HPPh2 in the presence of a copper(I)‐bisphosphine complex.
Efficient Removal of Antibiotics From Water via a Novel Magnetic Hypercrosslinked Polymer
Authors: Liu Yin , Chen Shanhu , Shen Liang , Zhang Qiuyu 
Published: November 2024

ABSTRACTThe removal of antibiotic residues from environmental media is a significant challenge in the field of chemistry. In this work, we presented a simple and efficient method for eliminating tetracycline hydrochloride (TC) and chloramphenicol (CAP) from water. Initially, 1,4‐dichlorobenzene and ferrocene were employed as starting materials for the synthesis of hypercrosslinked polymers (HFDs) via Friedel–Crafts alkylation facilitated by a cross‐linking agent. Subsequent to this, an efficient magnetic adsorbent material (MHFD) was developed by the in situ oxidation of the iron source incorporated within the polymer matrix of HFDs. The resulting MHFDs demonstrated an impressive maximum Brunauer–Emmett–Teller (BET)–specific surface area of 1190 m2/g and exhibited a peak saturation magnetization of 11.8 emu/g. This work investigated the effects of four factors on the adsorption performance of MHFD‐10, including contact time, solution pH, dosage of MHFD‐10, and initial antibiotic concentration. The results revealed a remarkable conformity of the adsorption kinetics with the pseudo‐second‐order model and the adsorption isotherms with the Langmuir model. Thermodynamic analysis revealed that the adsorption process is spontaneous and exothermic. Specifically, at a temperature of 20°C, MHFD‐10 achieved maximum adsorption capacities of 193.95 mg/g for CAP and 268.60 mg/g for TC. Furthermore, these materials exhibited exceptional reusability, maintaining high adsorption capacities even after undergoing five consecutive reuse cycles.
Smartphone Application‐Based Addiction Scale: Psychometric Evidence Across Nine Asian Regions Using Advanced Analytic Methods
Authors: Chen I‐Hua , Pramukti Iqbal , Gan Wan Ying , Ruckwongpatr Kamolthip , Pham Le An , Huang Po‐Ching , Mamun Mohammed A. , Ullah Irfan , Jahrami Haitham A. , Lin Chung‐Ying , Pakpour Amir H. 
Published: November 2024

ABSTRACTIntroductionA smartphone is a device with various functions, including wifi, application functions, mobile networks, ease of mobility, and the capability of using mobile data. Because of the aforementioned functions, people may use smartphones frequently. The Smartphone Application‐Based Addiction Scale (SABAS) is a six‐item questionnaire assessing smartphone addiction with promising psychometric properties. However, it is unclear if the SABAS possesses the strong psychometric properties across Asian regions. The present study aimed to examine the factor structure of the SABAS across nine Asian regions.MethodsUsing datasets collected from Asian regions of Bangladesh, China, Indonesia, Iran, Malaysia, Pakistan, Taiwan, Thailand, and Vietnam, data from 10,397 participants (mean age = 22.40 years; 44.8% men) were used for analyses. All participants completed the SABAS using an online survey or paper‐and‐pencil mode.ResultsFindings from confirmatory factor analysis, Rasch analysis, and network analysis all indicate a one‐factor structure for the SABAS. Moreover, the one‐factor structure of the SABAS was measurement invariant across age (21 years or less vs. above 21 years) and gender (men vs. women) in metric, scalar, and strict invariance. The one‐factor structure was invariant across regions in metric but not scalar or strict invariance.ConclusionThe present study findings showed that the SABAS possesses a one‐factor structure across nine Asian regions; however, noninvariant findings in scalar and strict levels indicate that people in the nine Asian regions may interpret the importance of each SABAS item differently. Age group and gender group comparisons are comparable because of the invariance evidence for the SABAS found in the present study. However, cautions should be made when comparing SABAS scores across Asian regions.
Behavioral Analyses in Dark Agouti Rats Following Repeated Systemic Treatment With Fingolimod (FTY720)
Authors: Jakobs Marie , Trautmann Lisa , Hadamitzky Martin , Bihorac Julia , Jacquet Lucie , Christians Uwe , Schniedewind Björn , Lückemann Laura , Schedlowski Manfred 
Published: November 2024

ABSTRACTBackgroundStudies in experimental animals revealed that acute and chronic treatment with small‐molecule immunosuppressive drugs lead to neurobehavioral alterations in rodents.MethodsAgainst this background, this study investigated behavioral alterations in rats after repeated administration of FTY720, an immunosuppressive drug used for the treatment of multiple sclerosis, employing the open field, elevated plus maze, and dark/light tests.ResultsCompared to controls, repeated FTY720 treatment affected behavior in rats, reflected by a reduction in distance traveled as well as increased time engaged in freezing in the open field and elevated plus maze. Furthermore, the time spent freezing in the elevated plus maze test positively correlated with FTY720 concentrations in the amygdala and insular cortex, two brain regions involved in regulation of emotionality. Since no changes in plasma corticosterone levels were observed, stress effects due to treatment, behavioral testing, or handling can be ruled out.ConclusionThe present findings indicate that treatment with FTY720 did not induce typical anxiety‐like behavioral patterns in otherwise healthy rats as seen following treatment with other immunosuppressive drugs. Nevertheless, it remains of great importance to evaluate behavioral effects in clinical practice to shed more light onto possible detrimental side effects emerging during treatment with small‐molecule immunosuppressive drugs.
Diabetes Mellitus and Risk of Future Stroke: Evidence From CHARLS and Mendelian Randomization Analyses
Authors: Bai Zetai , Wang Zheyi , Li Mei , Kong Deyuan , Wu Guanzhao 
Published: November 2024

AbstractObjectives: This study leveraged the China Health and Retirement Longitudinal Study (CHARLS) to explore the association between diabetes and stroke in middle‐aged and older adults in East Asia and assess the causality of this relationship using Mendelian randomization.Methods: Data from the 2011–2020 CHARLS cohort identified individuals with diabetes at baseline. Stroke incidence was self‐reported through standardized questionnaires. Logistic regression and restricted cubic spline analysis examined the relationship between diabetes and stroke risk alongside nonlinear correlations between glucose levels and stroke. Mendelian randomization clarified the causal link and analyzed the mediating effect between diabetes and stroke using genetic methods.Results: In the study population aged 45 and above, stroke incidence was 5.99% in normoglycemic, 6.82% in prediabetic, and 9.93% in diabetic individuals. Over 7 years, 473 strokes occurred. Diabetes was associated with a 1.35‐fold increased stroke risk compared to normoglycemia (OR = 1.35; 95% CI: 1.03–1.79). Subgroup analyses highlighted higher stroke risks in middle‐aged women, nonsmokers, and nondrinkers. Mendelian randomization supports a genetic causal relationship between diabetes and stroke. Diabetes may indirectly lead to stroke through the mediating effects of hypertension and high cholesterol.Conclusion: The findings confirm a significant association and causal link between diabetes and stroke risk in an East Asian population. In addition, the results indicate that controlling blood glucose in prediabetic individuals reduces stroke risk, with no similar benefits in diabetes.
Neurofilament Light Chain Is Associated With Acute Mountain Sickness
Authors: Berek Klaus , Lindner Anna , Pauli Franziska Di , Bsteh Gabriel , Treml Benedikt , Ponleitner Markus , Engler Clemens , Kleinsasser Axel , Berger Thomas , Wille Maria , Burtscher Martin , Deisenhammer Florian , Hegen Harald 
Published: November 2024

ABSTRACTBackgroundNeurological symptoms are common in acute mountain sickness (AMS); however, the extent of neuroaxonal damage remains unclear. Neurofilament light chain (NfL) is an established blood biomarker for neuroaxonal damage.ObjectiveTo investigate whether plasma (p) NfL levels increase after simulated altitude exposure, correlate with the occurrence of AMS, and might be mitigated by preacclimatization.MethodsHealthy subjects were exposed to simulated high altitude (4500 m) by the use of a normobaric hypoxic chamber at the University of Innsbruck two times, that is, within Cycle 1 (C1) over 12 h, and within Cycle 2 (C2) for another 12 h but with a random assignment to prior acclimatization or sham acclimatization. Before each cycle (measurement [M] 1 and 3) and after each cycle (M2 and M4), clinical data (arterial oxygen saturation [SaO2], heart rate, and Lake Louise AMS score [LLS]) and plasma samples were collected. pNfL was measured using single‐molecule array (Simoa) technique.ResultspNfL levels did not significantly change within each study cycle, but increased over the total study period (M1: 4.57 [3.34–6.39], M2: 4.58 [3.74–6.0], M3: 5.64, and M4: 6.53 [4.65–7.92] pg/mL, p < 0.001). Subjects suffering from AMS during the study procedures showed higher pNfL levels at M4 (6.80 [6.19–8.13] vs. 5.75 [4.17–7.35], p = 0.048), a higher total pNfL increase (2.88 [1.21–3.48] vs. 0.91 [0.53–1.48], p = 0.022) compared to subjects without AMS. An effect of preacclimatization on pNfL levels could not be observed.ConclusionspNfL increases alongside exposure to simulated altitude and is associated with AMS.
The role of online information sources in enhancing circular consumption behaviour: Fostering sustainable consumption patterns in the digital age
Authors: Talukder Md. Shamim , Biswas Mohammad Islam , Azad Nasreen 
Published: November 2024

AbstractCircular consumption is an element of the circular economy that is vital for fostering economic progress whilst addressing environmental degradation and resource scarcity. The majority of the existing studies on the circular economy focus on its organisational aspects and examine circular business models, including approaches to enhance circular value propositions and their advantages. However, the link amongst responsible consumption, digital technologies, consumer behaviour and the circular economy model has received limited attention. We aim to fill this gap by employing behavioural reasoning theory to investigate the intentions of consumers to engage in circular consumption behaviour. We enhance the theoretical robustness of our findings by integrating the theory of consumption values as ‘reason for’ and status quo bias theory as ‘reason against’. We conducted a questionnaire survey in two phases to validate our model and test our hypotheses. We collected our survey data from 305 respondents in Bangladesh and used partial least squares–structural equation modelling to validate our model. Results show that exposure to online information sources significantly influences the ‘reasons for’ and ‘reasons against’ factors. These two factors also demonstrate positive and negative associations with circular consumption behaviour, respectively. These findings offer important insights for service providers, policymakers and government entities.