bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhamnogalacturonan‐I is a determinant of cell–cell adhesion in poplar wood
Authors: Yang Haibing , Benatti Matheus R. , Karve Rucha A. , Fox Arizona , Meilan Richard , Carpita Nicholas C. , McCann Maureen C. 
Published: October 2019

SummaryThe molecular basis of cell–cell adhesion in woody tissues is not known. Xylem cells in wood particles of hybrid poplar (Populus tremula × P. alba cv. INRA 717‐1B4) were separated by oxidation of lignin with acidic sodium chlorite when combined with extraction of xylan and rhamnogalacturonan‐I (RG‐I) using either dilute alkali or a combination of xylanase and RG‐lyase. Acidic chlorite followed by dilute alkali treatment enables cell–cell separation by removing material from the compound middle lamellae between the primary walls. Although lignin is known to contribute to adhesion between wood cells, we found that removing lignin is a necessary but not sufficient condition to effect complete cell–cell separation in poplar lines with various ratios of syringyl:guaiacyl lignin. Transgenic poplar lines expressing an Arabidopsis thaliana gene encoding an RG‐lyase (AtRGIL6) showed enhanced cell–cell separation, increased accessibility of cellulose and xylan to hydrolytic enzyme activities, and increased fragmentation of intact wood particles into small cell clusters and single cells under mechanical stress. Our results indicate a novel function for RG‐I, and also for xylan, as determinants of cell–cell adhesion in poplar wood cell walls. Genetic control of RG‐I content provides a new strategy to increase catalyst accessibility and saccharification yields from woody biomass for biofuels and industrial chemicals.
Genetic variability and GxE interactions for total polyphenol content and antioxidant activity in white and red sorghums (Sorghum bicolor)
Authors: Aruna Chandrasekhara Reddy , Ratnavathi Chamarthy Venkata , Suguna Medicherla , Ranga Bukhya , Praveen Kumar Penugonda , Annapurna Aluri , Bahadure Dhyaneshwar Motiram , Toapi Vilas A. 
Published: October 2019

AbstractSorghum has unique advantage in terms of its climate resilience and its grain composition with beneficial bioactive compounds. It is a very good source of bioactive compounds such as polyphenols and antioxidants. Breeding efforts for end‐use identity‐specific genotypes are required for increased profitability to the farmers. In this study, total polyphenol content (TPC) and free radical scavenging activity (FRSA) were estimated in 60 genotypes, comprising of white and red sorghums, over three years each with two replications. TPC ranged from 55.6 mg/100 g to 553.1 mg/100 g with the highest value in IS 30508. The highest antioxidant activity, measured as free radical scavenging activity, was observed in IS 16151. Though in general TPC and FRSA are high in red sorghums, not all red sorghums have high TPC and scavenging activity. Significant effects of genotype and environment were observed for all the characters. Correlation studies indicated the possibility of developing a high yielding line with high antioxidant activity. The information generated aids in identifying donors to develop end‐use specific genotypes that are suitable as functional foods.
Development and validation of a 21st Century Skills Assessment: Using an iterative multimethod approach
Authors: Sondergeld Toni A. , Johnson Carla C. 
Published: October 2019

AbstractIn response to the call for more rigorously validated educational assessments, this study used an iterative multimethod validation process to develop and validate outcomes from the 21st Century Skills Assessment global rating scale. Qualitative and quantitative data sources were used to inform four types of validity evidence: content, response process, internal structure, and consequential. STEM experts and typical assessment users provided support for content, response process, and consequential validity evidence through focus group interviews and cognitive interviews. Psychometric findings suggest strong internal validity evidence for the assessment through high measures of internal consistency reliability, intra‐rater agreement, and test–retest reliability measures.
High school students' use of representations in physics problem solving
Authors: Lucas Lyrica L. , Lewis Elizabeth B. 
Published: October 2019

AbstractFindings from physics education research strongly point to the critical need for teachers’ use of multiple representations in their instructional practices such as pictures, diagrams, written explanations, and mathematical expressions to enhance students' problem‐solving ability. In this study, we explored use of problem‐solving tasks for generating multiple representations as a scaffolding strategy in a high school modeling physics class. Through problem‐solving cognitive interviews with students, we investigated how a group of students responded to the tasks and how their use of such strategies affected their problem‐solving performance and use of representations as compared to students who did not receive explicit, scaffolded guidance to generate representations in solving similar problems. Aggregated data on students' problem‐solving performance and use of representations were collected from a set of 14 mechanics problems and triangulated with cognitive interviews. A higher percentage of students from the scaffolding group constructed visual representations in their problem‐solving solutions, while their use of other representations and problem‐solving performance did not differ with that of the comparison group. In addition, interviews revealed that students did not think that writing down physics concepts was necessary despite being encouraged to do so as a support strategy.
Intermediate-term outcomes of Aurolab aqueous drainage implant in refractory paediatric glaucoma
Authors: Puthuran George Varghese , Palmberg Paul Frederic , Wijesinghe Hiruni Kaushalya , Pallamparthy Srilekha , Krishnadas SR , Robin Alan L 
Published: October 2019

AimTo report the intermediate-term outcomes of Aurolab aqueous drainage implant (AADI) surgery in paediatric eyes with refractory glaucoma.MethodsCase records of patients below 18 years, who underwent AADI surgery between 2012 and 2015 with >2 years follow-up, were analysed. The intraocular pressure (IOP), visual acuity, number of antiglaucoma medications, complications and resurgery if any were recorded at baseline, day 1and then at months 1, 3, 6, 9, 12, 18, 24 and at the last visit. Failure was defined as IOP >18 mm Hg or not reduced by at least 30% below baseline, IOP ≤5 mm Hg on two consecutive follow-up visits after 3 months, reoperation for a complication or loss of light perception vision.Results101 eyes of 101 patients were included with a mean age of 10.4±4.7 years at the time of surgery and a mean follow-up of 40.9±15.1 months. Glaucoma following cataract surgery was the most common type of glaucoma (n=31, 30%), followed by primary congenital glaucoma (n=29, 29%). The cumulative probability of failure was 15.8% (95% CI 10.1% to 24.5%) at 1 year, 22.7% (95% CI 15.7% to 32.2%) at 2 years, 42.5% (95% CI 32.6% to 53.9%) at 3 years and 62.1% (95% CI 49.5% to 74.8%) at the 4 years time point.ConclusionThe AADI showed excellent success until 2 years after surgery in paediatric eyes after which failure rates increased. Further prospective studies with longer follow-up are required to evaluate the long-term success of the AADI for paediatric glaucomas.
Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study
Authors: Skoog Ståhlgren Gunilla , Tyrstrup Mia , Edlund Charlotta , Giske Christian G , Mölstad Sigvard , Norman Christer , Rystedt Karin , Sundvall Pär-Daniel , Hedin Katarina 
Published: October 2019

Abstract

Objective
To determine whether total exposure to penicillin V can be reduced while maintaining adequate clinical efficacy when treating pharyngotonsillitis caused by group A streptococci.

Design
Open label, randomised controlled non-inferiority study.

Setting
17 primary healthcare centres in Sweden between September 2015 and February 2018.

Participants
Patients aged 6 years and over with pharyngotonsillitis caused by group A streptococci and three or four Centor criteria (fever ≥38.5°C, tender lymph nodes, coatings of the tonsils, and absence of cough).

Interventions
Penicillin V 800 mg four times daily for five days (total 16 g) compared with the current recommended dose of 1000 mg three times daily for 10 days (total 30 g).

Main outcome measures
Primary outcome was clinical cure five to seven days after the end of antibiotic treatment. The non-inferiority margin was prespecified to 10 percentage points. Secondary outcomes were bacteriological eradication, time to relief of symptoms, frequency of relapses, complications and new tonsillitis, and patterns of adverse events.

Results
Patients (n=433) were randomly allocated to the five day (n=215) or 10 day (n=218) regimen. Clinical cure in the per protocol population was 89.6% (n=181/202) in the five day group and 93.3% (n=182/195) in the 10 day group (95% confidence interval −9.7 to 2.2). Bacteriological eradication was 80.4% (n=156/194) in the five day group and 90.7% (n=165/182) in the 10 day group. Eight and seven patients had relapses, no patients and four patients had complications, and six and 13 patients had new tonsillitis in the five day and 10 day groups, respectively. Time to relief of symptoms was shorter in the five day group. Adverse events were mainly diarrhoea, nausea, and vulvovaginal disorders; the 10 day group had higher incidence and longer duration of adverse events.

Conclusions
Penicillin V four times daily for five days was non-inferior in clinical outcome to penicillin V three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci. The number of relapses and complications did not differ between the two intervention groups. Five day treatment with penicillin V four times daily might be an alternative to the currently recommended 10 day regimen.

Trial registration

EudraCT 2015-001752-30;
ClinicalTrials.gov
NCT02712307
.
Preventing depression in the community by voluntary sector providers (PERSUADE): intervention development and protocol for a parallel randomised controlled feasibility trial
Authors: Kenning Cassandra , Blakemore Amy , Bower Peter , Safari Melina , Cuijpers Pim , Brown June SL , Hann Mark , Lidbetter Nicky , Muñoz Ricardo F , Waheed Waquas 
Published: October 2019

IntroductionDepression is now the most common illness worldwide affecting more than 300 million people. Studies modelling the impact of depression interventions have shown that the burden of depression cannot be minimised by more than 35% with existing treatments. There is a need to develop better preventative interventions. The overall aim of this programme of work is to develop interventions to reduce depression symptom scores and prevent development of depression in people with subthreshold depression. The objectives are to adapt a low intensity community-based depression prevention intervention, establish the acceptability and uptake of this model and conduct a parallel randomised controlled feasibility trial to inform a full-scale trial.Methods and analysisFocus groups will be run with members of the public, voluntary sector providers and researchers to inform the adaptation of an existing depression prevention course. Sixty-four people with subthreshold depression, as represented by a score of between 5 and 9 on the Patient Health Questionnaire-9 depression measure, will be recruited to take part in the feasibility trial. Participants will be randomised equally to the intervention or usual care control groups. Participants in the intervention group will receive the new revised manual and attend a 1-day workshop delivered by voluntary sector service providers. Outcome measures will be completed 3 months after baseline. Quantitative data on recruitment, randomisation, attendance, retention, questionnaire completion rates will be collected. Primary analyses will be descriptive and a process evaluation will be conducted to assess the processes involved in implementing the intervention. Interviews will be conducted to explore acceptability and framework analysis will be used to analyse the data.Ethics and disseminationThe study has been reviewed and approved by NHS Research and Ethics Committee: NW-Greater Manchester East. The results will be actively disseminated through peer-reviewed journals, conference presentations, social media, the internet and community engagement activities.Trial registration numberISRCTN23278208;Pre-results.
Effect of dose administration aids on adherence to self-administered medications: a systematic review protocol
Authors: Chaudhri Kanika , Kearney Madeleine , Day Richard O , Rodgers Anthony , Atkins Emily 
Published: October 2019

IntroductionForgetting to take a medication is the most common reason for non-adherence to self-administered medication. Dose administration aids (DAAs) are a simple and common solution to improve unintentional non-adherence for oral tablets. DAAs can be in the form of compartmentalised pill boxes, automated medication dispensing devices, blister packs and sachets packets. This protocol aims to outline the methods that will be used in a systematic review of the current literature to assess the impact of DAAs on adherence to medications and health outcomes.Methods and analysisRandomised controlled trials will be identified through electronic searches in databases including EMBASE, MEDLINE, CINAHL and the Cochrane Library, from the beginning of each database until January 2020. Two reviewers will independently screen studies and extract data using the standardised forms. Data extracted will include general study information, characteristics of the study, participant characteristics, intervention characteristics and outcomes. Primary outcome is to assess the effects of DAAs on medication adherence. Secondary outcome is to evaluate the changes in health outcomes. The risk of bias will be ascertained by two reviewers in parallel using The Cochrane Risk of Bias Tool. A meta-analysis will be performed if data are homogenous.Ethics and disseminationEthics approval will not be required for this study. The results of the review described within this protocol will be disseminated through publication in a peer-reviewed journal and relevant conference presentations.PROSPERO registration numberCRD42018096087
Training opportunities in thoracic ultrasound for respiratory trainees: are current guidelines practical?
Authors: Stanton Andrew E , Evison Matthew , Roberts Mark , Latham Jennifer , Clive Amelia O , Batalla-Duran Elizabeth , Bhatnagar Rahul , Asciak Rachelle , Diggins Ben , Bintcliffe Oliver J , Lees Diana , Parsonage Maria , Denny Peppa , Gow Kathryn , Avram Cristina , Gautam Manish , Rahman Najib M 
Published: October 2019

IntroductionRespiratory trainees in the UK face challenges in meeting current Royal College of Radiologists (RCR) Level 1 training requirements for thoracic ultrasound (TUS) competence, specified as attending ‘at least one session per week over a period of no less than 3 months, with approximately five scans per session performed by the trainee (under supervision of an experienced practitioner)’. We aimed to clarify where TUS training opportunities currently exist for respiratory registrars.MethodsData were collected (over a 4-week period) to clarify the number of scans (and therefore volume of training opportunities) within radiology departments and respiratory services in hospitals in the South West, North West deaneries and Oxford.Results14 hospitals (including three tertiary pleural centres) provided data. Of 964 scans, 793 (82.3%) were conducted by respiratory teams who performed a mean of 17.7 scans per week, versus 3.1 TUS/week in radiology departments. There was no radiology session in any hospital with ≥5 TUS performed, whereas 8/14 (86%) of respiratory departments conducted such sessions. Almost half (6/14) of radiology departments conducted no TUS scans in the period surveyed.ConclusionsThe currently recommended exposure of regularly attending a list or session to undertake five TUS is not achievable in radiology departments. The greatest volume of training opportunities exists within respiratory departments in a variety of scheduled and unscheduled settings. Revision of the competency framework in TUS, and where this is delivered, is required.
Advantage of the second-order formalism in double space T-dualization of type II superstring
Authors: Nikolić B. , Sazdović B. 
Published: October 2019

Abstract
In this article we present bosonic T-dualization in double space of the type II superstring theory in the pure spinor formulation. We use the action with constant background fields obtained from the general case under some physically and mathematically justified assumptions. Unlike Nikolić and Sazdović (EPJ C 77:197, 2017), where we used the first-order theory, in this article fermionic momenta are integrated out. Full T-dualization in double space is represented as a permutation of the initial $$x^\mu $$xμ and T-dual coordinates $$y_\mu $$yμ. Requiring that a T-dual transformation law of the T-dual double coordinate $${}^\star Z^M=(y_\mu ,x^\mu )$$⋆ZM=(yμ,xμ) to be of the same form as for initial one $$Z^M=(x^\mu ,y_\mu )$$ZM=(xμ,yμ), we obtain the form of the T-dual background fields in terms of the initial ones. The advantage of using the action with integrated fermionic momenta is that it gives all T-dual background fields in terms of the initial ones. In the case of the first-order theory Nikolić and Sazdović (2017) a T-dual R-R field strength was obtained out of the double space formalism under additional assumptions.
Non-Abelian aether-like term in four dimensions
Authors: Carvalho A. J. G. , Granado D. R. , Nascimento J. R. , Petrov A. Yu. 
Published: October 2019

Abstract
The non-Abelian aether-like Lorentz-breaking term, involving triple and quartic self-coupling vertices, is generated from the non-Abelian generalization of the Lorentz-breaking extended QED including only a minimal spinor-vector interaction. This term is shown explicitly to be finite and non-ambiguous.
Inflation, (p)reheating and neutrino anomalies: production of sterile neutrinos with secret interactions
Authors: Paul Arnab , Ghoshal Anish , Chatterjee Arindam , Pal Supratik 
Published: October 2019

AbstractA number of experimental anomalies involving neutrinos hint towards the existence of at least an extra (a very light) sterile neutrino. However, such a species, appreciably mixing with the active neutrinos, is disfavored by different cosmological observations like Big Bang Nucleosynthesis (BBN), Cosmic Microwave Background (CMB) and Large Scale Structure (LSS). Recently, it was shown that the presence of additional interactions in the sterile neutrino sector via light bosonic mediators can make the scenario cosmologically viable by suppressing the production of the sterile neutrinos from active neutrinos via matter-like effect caused by the mediator. This mechanism works assuming the initial population of this sterile sector to be negligible with respect to that of the Standard Model (SM) particles, before the production from active neutrinos. However, there is fair chance that such bosonic mediators may couple to the inflaton and can be copiously produced during (p)reheating epoch. Consequently, they may ruin this assumption of initial small density of the sterile sector. In this article we, starting from inflation, investigate the production of such a sterile sector during (p)reheating in a large field inflationary scenario and identify the parameter region that allows for a viable early Universe cosmology.
Levity Makes the Law: Islamic Legal Riddles
Authors: Keegan Matthew L. 
Published: October 2019

Abstract
This article traces the emergence of compilations of a particular kind of legal riddle in the 8th/14th century, with special reference to the compilation of Ibn Farḥūn (d. 799/1397). Ibn Farḥūn’s riddles could be solved only by someone with detailed knowledge of Islamic positive law (furūʿ), and he argues that they are both an appropriate form of restful entertainment and a kind of competitive pedagogy. At the same time, Ibn Farḥūn derived novel legal opinions on the basis of his riddles, which demonstrates that jurists used hypothetical, imaginative situations to derive new rulings. The article also traces the origins of furūʿ-based legal riddles in the more diffuse tradition of Islamic riddling and in the adab tradition of riddling.
Long-Term Global Irradiance Calibration of Multifilter UV Radiometers
Authors: Piedehierro A. A. , Cancillo M. L. , Vilaplana J. M. , Serrano A. 
Published: October 2019

AbstractMultifilter instruments such as the Norwegian Institute for Air Research (NILU)-UV Irradiance Meter (NILU-UV) are suitable for long-term monitoring of UV radiation, as long as their irradiance scale is maintained. The sensitivity of these instruments varies with time; thus, periodic standard absolute calibrations are required. However, standard calibrations may be insufficient to characterize the short-term variations of channels sensitivity. Therefore, results from standard calibrations have to be combined with the information derived from frequent relative calibrations, leading to a stable irradiance scale. This paper focuses on the long-term application of three calibration methods, hereinafter referred to as CC, CC2, and CC2(ϕ), as applied to the NILU-UV 119 multifilter radiometer. Here a generalization is proposed, consisting of using empirical functions in order to guarantee the accurate calibration of multifilter instruments over long time periods. These function-based methods need to be updated regularly to account for changes on instrument sensitivity. The changes in sensitivity of the NILU-UV 119 were found to be channel dependent. The detected drifts range from 23% to 42% for a 4-yr period of study. Time series of calibrated irradiance are obtained by applying the proposed methods. Results suggest that calibration methods using empirical functions perform better than classic calibration approaches that use constant calibration factors. When methods CC2 and CC2(ϕ) are applied, calibrated irradiances agree with the measurements of reference within ±5% for channel 305 and within ±3% for channels 312, 320, and 340.