bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory dominance and multisensory integration as screening tools in aging
Authors: Murray Micah M. , Eardley Alison F. , Edginton Trudi , Oyekan Rebecca , Smyth Emily , Matusz Pawel J. 
Published: June 2018

AbstractMultisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals’ learning and memory impairments. First, we provide much-needed clarification regarding the presence of enhanced multisensory benefits in both healthily and abnormally aging individuals. The pattern of sensory dominance shifted with healthy and abnormal aging to favour a propensity of auditory-dominant behaviour (i.e., detecting sounds faster than flashes). Notably, multisensory benefits were larger only in healthy older than younger individuals who were also visually-dominant. Second, we demonstrate that the multisensory detection task offers benefits as a time- and resource-economic MCI screening tool. Receiver operating characteristic (ROC) analysis demonstrated that MCI diagnosis could be reliably achieved based on the combination of indices of multisensory integration together with indices of sensory dominance. Our findings showcase the importance of sensory profiles in determining multisensory benefits in healthy and abnormal aging. Crucially, our findings open an exciting possibility for multisensory detection tasks to be used as a cost-effective screening tool. These findings clarify relationships between multisensory and memory functions in aging, while offering new avenues for improved dementia diagnostics.
In vitro and in vivo evaluation of electrophoresis-aided casein phosphopeptide-amorphous calcium phosphate remineralisation system on pH-cycling and acid-etching demineralised enamel
Authors: Zhang Yu Yuan , Wong Hai Ming , McGrath Colman P. J. , Li Quan Li 
Published: June 2018

AbstractCasein phosphate-amorphous calcium phosphate (CPP-ACP), as a remineralisation agent, is extensively used in managing demineralised enamel; however, its remineralisation kinetics is low. This study aimed to improve remineralisation kinetics of CPP-ACP by introducing a rapid remineralisation method with electrophoresis. In vitro, a pH-cycling enamel model was used to test remineralisation potentials of electrophoresis-aided CPP-ACP. For verifying remineralisation potentials of electrophoresis-aided CPP-ACP in vivo in a rabbit model, acid-etched enamel surface on rabbit maxillary incisors was remineralised by electrophoresis-aided CPP-ACP with 1.0 mA (group A) or 0.5 mA (group B). Both in vitro and in vivo, it was observed that electrophoresis was benefit to improve remineralisation kinetics of CPP-ACP, and the demineralised enamel was completely remineralised after 5 h. The Ca/P ratio in remineralised enamel consisted with that of hydroxyapatite, the microstructure in native enamel. Meanwhile, in vivo the micro-hardness of acid-etched enamel in group A (322.55 ± 31.90) and group B (322.55 ± 31.90) recovered up to the value of native enamel after 5 h remineralisation (p > 0.05). The Hematoxylin-eosin stain demonstrated that the electric field used in this study was safe on rabbit dental pulp. Therefore, this efficient and safe method has the potential to be applied in treating enamel deminerlisation.
A seven-lncRNA signature predicts overall survival in esophageal squamous cell carcinoma
Authors: Mao Yu , Fu Zhanzhao , Zhang Yunjie , Dong Lixin , Zhang Yanqiu , Zhang Qiang , Li Xin , Liu Jia 
Published: June 2018

AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer and the leading causes of cancer-related mortality worldwide, especially in Eastern Asia. Here, we downloaded the microarray data of lncRNA expression profiles of ESCC patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data sets and divided into training, validation and test set. The random survival forest (RSF) algorithm and Cox regression analysis were applied to identify a seven-lncRNA signature. Then the predictive ability of the seven-lncRNA signature was evaluated in the validation and test set using Kaplan-Meier test, time-dependent receiver operating characteristic (ROC) curves and dynamic area under curve (AUC). Stratified analysis and multivariate Cox regression also demonstrated the independence of the signature in prognosis prediction from other clinical factors. Besides, the predict accuracy of lncRNA signature was much better than that of tumor-node-metastasis (TNM) stage in all the three sets. LncRNA combined with TNM displayed better prognostic predict ability than either alone. The role of LINC00173 from the signature in modulating the proliferation and cell cycle of ESCC cells was also observed. These results indicated that this seven-lncRNA signature could be used as an independent prognostic biomarker for prognosis prediction of patients with ESCC.
PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma
Authors: Valanejad Leila , Cast Ashley , Wright Mary , Bissig Karl-Dimiter , Karns Rebekah , Weirauch Matthew T. , Timchenko Nikolai 
Published: June 2018

AbstractHepatoblastoma (HBL) is a pediatric liver cancer that affects children under the age of three. Reduction of tumor suppressor proteins (TSPs) is commonly seen in liver cancer. However, in our studies we find that aggressive, chemo-resistant HBLs exhibit an elevation of TSPs. HBL patients with a classic phenotype have reduced TSP levels, but patients with aggressive HBL express elevated TSPs that undergo posttranslational modifications, eliminating their tumor suppression activities. Here we identify unique aggressive liver cancer domains (ALCDs) that are activated in aggressive HBL by PARP1-mediated chromatin remodeling leading to elevation of modified TSPs and activation of additional cancer pathways: WNT signaling and β-catenin. Inhibition of PARP1 blocks activation of ALCDs and normalizes expression of corresponding genes, therefore reducing cell proliferation. Our studies reveal PARP1 activation as a mechanism for the development of aggressive HBL, further suggesting FDA-approved PARP1 inhibitors might be used for treatment of patients with aggressive HBL.
Global gene expression profiling for fruit organs and pathogen infections in the pepper, Capsicum annuum L.
Authors: Kim Myung-Shin , Kim Seungill , Jeon Jongbum , Kim Ki-Tae , Lee Hyun-Ah , Lee Hye-Young , Park Jieun , Seo Eunyoung , Kim Saet-Byul , Yeom Seon-In , Lee Yong-Hwan , Choi Doil 
Published: June 2018

AbstractHot pepper (Capsicum annuum) is one of the most consumed vegetable crops in the world and useful to human as it has many nutritional and medicinal values. Genomic resources of pepper are publically available since the pepper genomes have been completed and massive data such as transcriptomes have been deposited. Nevertheless, global transcriptome profiling is needed to identify molecular mechanisms related to agronomic traits in pepper, but limited analyses are published. Here, we report the comprehensive analysis of pepper transcriptomes during fruit ripening and pathogen infection. For the ripening, transcriptome data were obtained from placenta and pericarp at seven developmental stages. To reveal global transcriptomic landscapes during infection, leaves at six time points post-infection by one of three pathogens (Phytophthora infestans, Pepper mottle virus, and Tobacco mosaic virus P0 strain) were profiled. The massive parallel transcriptome profiling in this study will serve as a valuable resource for detection of molecular networks of fruit development and disease resistance in Capsicum annuum.
Mutual coupling reduction in multilayer patch antennas via meander line parasites
Authors: Maddio S. , Pelosi G. , Righini M. , Selleri S. , Vecchi I. 
Published: June 2018

A method to reduce the mutual coupling in wide‐band multilayer patch array operating in C band is presented. The proposed device use conveniently sized meander line parasites printed on the same substrate of the upper patch. Measurements on a prototype shows a measured bandwidth of about 19.6% centred at 5.1 GHz, therefore adequate to cover the whole WLAN frequency range. The meander lines allow to reduce the patch mutual coupling by about 2.4 dB.
Numerical analysis of film‐loaded silicon nanowire optical rectangular waveguide: an effective optical sensing
Authors: Singh Ritu Raj , Priye Vishnu 
Published: June 2018

Subwavelength waveguide using silicon nanowires is investigated for its compatibility with silicon‐on‐insulator platform. A layer of silicon film over SiO2 substrate is employed to construct silicon nanowire waveguides that complies with standard 220 nm silicon height technology. The proposed structure is further investigated for its utility as an optical sensing element in photonic integrated circuits. Film‐loaded silicon nanowire optical rectangular waveguide (SNORW) allows light to be guided inside low refractive indexed gapping region with optimised dimension. Fully numerical analysis is performed using finite‐element method as evidence to support the guiding phenomena of this waveguide. Eventually, confinement factor and waveguide sensitivity is found to be linear with measurand refractive index. As a result, the purpose of this SNORW leads to an effective sensing in the new era of photonics.
Temporal enhanced sentence‐level attention model for hashtag recommendation
Authors: Ma Jun , Feng Chong , Shi Ge , Shi Xuewen , Huang Heyang 
Published: June 2018

Hashtags of microblogs can provide valuable information for many natural language processing tasks. How to recommend reliable hashtags automatically has attracted considerable attention. However, existing studies assumed that all the training corpus crawled from social networks are labelled correctly, while large sample statistics on real social media shows that there are 8.9% of microblogs with hashtags having wrong labels. The notable influence of noisy data to the classifier is ignored before. Meanwhile, recency also plays an important role in microblog hashtag, but the information is not used in the existing studies. Some temporal hashtags such as World Cup will ignite at a particular time, but at other times, the number of people talking about it will sharply decrease. To address the twofold shortcomings above, the authors propose an long short‐term memory‐based model, which uses temporal enhanced selective sentence‐level attention to reduce the influence of wrong labelled microblogs to the classifier. Experimental results using a dataset of 1.7 million microblogs collected from SINA Weibo microblogs demonstrated that the proposed method could achieve significantly better performance than the state‐of‐the‐art methods.
Are all RR Lyrae stars modulated?
Authors: Kovacs Geza 
Published: June 2018

We analyzed 151 variables previously classified as fundamental mode RR Lyrae stars from Campaigns 01–04 of the Kepler two-wheel (K2) archive. By employing a method based on the application of systematics filtering with the aid of co-trending light curves in the presence of a large amplitude signal component, we searched for additional Fourier signals in the close neighborhood of the fundamental period. We found only 13 stars without such components, yielding the highest rate of modulated (Blazhko) stars detected so far (91 %). A detection efficiency test suggests that this occurrence rate likely implies a 100 % underlying rate. Furthermore, the same test performed on a subset of the Large Magellanic Cloud RR Lyrae stars from the MACHO archive shows that the conjecture of high true occurrence rate fits well to the low observed rate derived from this database.
Economic model of an innovative enterprise in the digital economy
Authors: Demidenko Daniil , Dubolazova Julia , Malevskaya-Malevich Ekaterina 
Published: June 2018

Currently, the innovation vector is a necessary condition for development of high-tech and high-efficiency industries, a competitiveness factor of enterprise products in market conditions in any economic activity forms. In conditions of transfer to the digital economy, the innovation process – as an incentive for technological modernization of production, increasing of its efficiency and development of new competitive products – allows generating relatively high value added that in terms of corporate finance is a key factor in increasing the company market value that in turn is a generally accepted criterion of the economic efficiency of the enterprise activity as a whole.
The article specifies the concept of the economic model of the enterprise that performs innovative activities in conditions of the digital economy. A comparative analysis of the economic model of the enterprise that does not implement innovation and the innovative enterprise is carried out. The economic model of the innovative enterprise proposes a gradual transition from the production of simple goods to science-intensive and high-technology products by increasing in the level of production development, technologies and skills of employees. The process for formation of the economic model of the enterprise is a mechanism that is a set of elements unified by the system of direct and back links between them and intended to create value added. Based on the performed analysis, it was detected that the innovation enterprise has a number of preferences that compensates for the innovative risk and increases the value added. The model of the value added of the enterprise that performs innovative activity is formulated.
Antegrade pancreatoscopy via EUS-guided pancreaticogastrostomy allows removal of obstructive pancreatic duct stones
Authors: James Theodore , Baron Todd 
Published: June 2018

Abstract
Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) is an effective treatment for pancreaticolithiasis, including use of pancreatoscopy for intraductal electrohydraulic lithotripsy (IEHL). Pancreatoscopy is often limited by a small-caliber downstream pancreatic duct as well as an unstable pancreatoscope position within the pancreatic head. Endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PG) has been developed as a method to relieve ductal obstruction when retrograde access fails. The current study describes pancreatoscopy via EUS-PG, a novel method for managing obstructing pancreaticolithiasis.
Patients and methods From September 2017 to January 2018, patients who underwent EUS-PG followed by antegrade pancreatoscopy via PG were identified. Endoscopy reports, medical charts and relevant laboratory data were reviewed and recorded.
Results Five patients underwent EUS-PG and antegrade pancreatoscopy via PG during the study period; clinical success rate was 100 %. There were no significant adverse events during the procedure or follow up period.
Conclusions Pancreatoscopy via PG for IEHL is safe and effective for treating obstructing pancreaticolithiasis in patients who have previously failed ERCP or in clinical scenarios were ERCP is not possible.
Isolated Avulsion of the Tendon of Insertion of the Infraspinatus and Supraspinatus Muscles in Five Juvenile Labrador Retrievers
Authors: Piras Alessandro , Hakala Laura , Mikola Karoliina 
Published: June 2018

Case History Five juvenile Labrador Retrievers between the ages of 6 and 8 months were presented to our referral centres with a history of intermittent forelimb lameness.
Clinical Examination The clinical examination revealed the presence of bilateral orthopaedic problems in four out of five cases.
Diagnostic Imaging Findings Radiographic and computed tomography examinations showed the presence of a radiolucent defect corresponding to the area of insertion of the infraspinatus or supraspinatus tendons on the proximal humerus. Three dogs were concurrently affected by elbow disease on the contralateral forelimb and one dog with bilateral infraspinatus avulsion also had osteochondritis dissecans affecting both shoulder joints.
Diagnosis Avulsion of the insertion of the infraspinatus tendon in four dogs and of the supraspinatus tendon in one dog.
Clinical Relevance According to the current literature, the incidence of infraspinatus and supraspinatus tendinopathies in adult Labrador Retrievers is higher than in other breeds. In our five cases, the patients were juvenile and the nature of the injury was an avulsion of the tendinous insertion. Avulsion of the tendon of insertion of the infraspinatus or supraspinatus has been poorly described in the veterinary literature, and this would represent the first series of cases affecting juvenile Labrador Retrievers.
Response to Individualized Homeopathic Treatment for Depression in Climacteric Women with History of Domestic Violence, Marital Dissatisfaction or Sexual Abuse: Results from the HOMDEP-MENOP Study
Authors: Llanes-González Lidia , Aguilar-Faisal Leopoldo , Asbun-Bojalil Juan , Macías-Cortés Emma 
Published: June 2018

Background Although individualized homeopathic treatment is effective for depression in climacteric women, there is a lack of well-designed studies of its efficacy for depression in battered women or in post-traumatic stress disorder. The aim of this study was to assess the association between individualized homeopathic treatment or fluoxetine and response to depression treatment in climacteric women with high levels of domestic violence, sexual abuse or marital dissatisfaction.
Materials and Methods One hundred and thirty-three Mexican climacteric women with moderate-to-severe depression enrolled in the HOMDEP-MENOP Study (a randomized, placebo-controlled, double-blind, double-dummy, three-arm trial, with a 6-week follow-up study) were evaluated. Domestic violence, marital dissatisfaction and sexual abuse were assessed at baseline. Response to depression treatment was defined by a decrease of 50% or more from baseline score of Hamilton scale. Association between domestic violence, sexual abuse, and marital dissatisfaction and response to depression treatment was analyzed with bivariate analysis in the three groups. Odds ratio (OR) and 95% confidence interval (CI) were calculated.
Results Homeopathy versus placebo had a statistically significant association with response to depression treatment after adjusting for sexual abuse (OR [95% CI]: 11.07 [3.22 to 37.96]), domestic violence (OR [95% CI]: 10.30 [3.24 to 32.76]) and marital dissatisfaction (OR [95% CI]: 8.61 [2.85 to 25.99]).
Conclusions Individualized homeopathic treatment is associated with response to depression treatment in climacteric women with high levels of domestic violence, sexual abuse or marital dissatisfaction. Further studies should be conducted to evaluate its efficacy specifically for post-traumatic stress disorder in battered women.
ClinicalTrials.gov Identifier: NCT01635218, URL: http://clinicaltrials.gov/ct2/show/NCT01635218?term=depression+homeopathy&rank=1
Verschiedene Formen der Hämophilie
Authors: Deutsch E 
Published: June 2018

ZusammenfassungDie verschiedenen, durch Mangel eines für die Bildung der Plasmathrombokinase erforderlichen Faktors bedingten hämorrhagischen Diathesen — die Hypo-prothromboplastinämien — können nicht auf Grund ihrer klinischen Symptomatologie, sondern nur durch genaue Untersuchung der Gerinnungsstörung voneinander differenziert werden. Die Bezeichnung Hämophilie mit den Suffixen A und B sollte nur für jene geschlechtsgebunden-rezessiv vererbbaren hämorrhagischen Diathesen verwendet werden, die ausschließlich durch einen Mangel an Faktor VIII bzw. IX bedingt sind. Das Ausmaß der Verminderung dieser Faktoren ist innerhalb einer Familie konstant und erbmäßig bedingt, wodurch familiäre Krankheitstypen entstehen. Ein Mangel an Faktor VIII kann sich auch bei Patienten mit Faktor V-Mangel als Begleithämophilie und bei Patienten beiderlei Geschlechtes in Verbindung mit einer verlängerten Blutungszeit als Hämophilia vascularis finden. Die Kombination einer Verminderung von Faktor IX und VII sowie ihre mögliche Beziehung zur Verminderung des Stuart-Faktors wird diskutiert. Die physikalisch-chemischen Eigenschaften der für die Blutthrombokinasebildung erforderlichen Plasmafaktoren (mit Ausnahme von Faktor V) werden miteinander verglichen und die differentialdiagnostischen Möglichkeiten in Tabellen zusammengestellt. Das Fehlen eines Gerinnungsfaktors kann auch durch Blockierung durch einen Hemmstoff vorgetäuscht werden. Das Auftreten immunologisch bedingter Hemmstoffe bzw. die Vermehrung von Antikephalin ist für die Therapieresistenz hämophiler Patienten verantwortlich zu machen. Die Erkenntnisse über das Verhalten der Gerinnungsfaktoren der Vorphase ermöglichen eine differenzierte, planmäßige Therapie der Hypo-prothromboplastinämien.
Deficiency of the Hageman Factor Demonstrated by the Thrombin Generation Test
Authors: Sjølin Knud-Erik 
Published: June 2018

SummaryA coagulation defect in the plasma from a 37 year old man with no bleeding symptoms is described. The defect was revealed by the thrombin generation test and seemed to be caused by lack of the Hageman factor. The coagulation defect could be corrected by freezing of the plasma.
Kombinierte Untersuchungen hämorrhagischer Diathesen (II))
Authors: Gross Rudolf , Illig Leonhard , Macher Egon 
Published: June 2018

ZusammenfassungBei 22 Kranken mit hämorrhagischen Diathesen verschiedener Ätiologie wurden untersucht und auf ihre wechselseitigen Beziehungen geprüft:1. Blutgerinnung (Globaltests, Einzelfaktoren, spezielle Funktionsprüfungen) und Blutungszeit;2. Kapillarfragilität (Stauversuch nach Rumpel-Leede, Saugglockentests an verschiedenen Körperregionen) ;3. kapillarmikroskopischer und4. histologischer Befund im Bereich spontaner und mechanisch provozierter Petechien.Die Fragilitätstests wechseln von Hautabschnitt zu Hautabschnitt und sogar innerhalb gleicher Hautbezirke erheblich. In Hautabschnitten mit Spontanblutungen können sie normal und gleichzeitig in nicht betroffenen Hautbezirken pathologisch ausfallen.Die Kapillarmikroskopie ermöglicht eine Charakterisierung der Blutaustritte nach Art, Lokalisation und Größe; daneben läßt sie die klinisch nicht immer unterscheidbaren angiektatischen „Pseudopetechien” sicher von echten Blutaustritten abgrenzen. Spontane Blutungen können an allen sichtbaren Abschnitten der Endstrombahn auftreten; im Gegensatz zu den mechanisch provozierten Blutungen weisen sie bei vielen Patienten gewisse Eigentümlichkeiten hinsichtlich Form, Größe und Austrittsort auf. Im Gegensatz zu den bisher üblichen Vorstellungen scheinen Strömungsveidangsamung und Gefäßerweiterung für den spontanen Blutaustritt keine unbedingt notwendigen Voraussetzungen darzustellen. Umschriebene Erweiterungen stellen auch keinen ins Auge fallenden Lokalisations-faktor dar.Gefäßerweiterung, Strömungsverlangsamung und Blutung werden als voneinander unabhängige Folgen einer übergeordneten, zur Zeit morphologisch noch nicht faßbaren Gefäßwandschädigung aufgefaßt.Die histologische Untersuchung ermöglicht eine Unterscheidung von Blutungen mit und ohne entzündliche Infiltration, ferner die zytologische Differenzierung etwaiger Infiltrate und gegebenenfalls den Nachweis von Fibrin und Haemosiderin im Gewebe. Sie gibt einen Einblick in die Beteiligung auch tiefer gelegener Gefäßbezirke.