bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Characterization of Mobile Health Apps' Features by Extracting Information From the Web: An Exploratory Study
Authors: Paglialonga Alessia , Schiavo Massimo , Caiani Enrico Gianluca 
Published: November 2018

Purpose
The aim of this study was to test the viability of a novel method for automated characterization of mobile health apps.

Method
In this exploratory study, we developed the basic modules of an automated method, based on text analytics, able to characterize the apps' medical specialties by extracting information from the web. We analyzed apps in the Medical and Health & Fitness categories on the U.S. iTunes store.

Results
We automatically crawled 42,007 Medical and 79,557 Health & Fitness apps' webpages. After removing duplicates and non-English apps, the database included 80,490 apps. We tested the accuracy of the automated method on a subset of 400 apps. We observed 91% accuracy for the identification of apps related to health or medicine, 95% accuracy for sensory systems apps, and an average of 82% accuracy for classification into medical specialties.

Conclusions
These preliminary results suggested the viability of automated characterization of apps based on text analytics and highlighted directions for improvement in terms of classification rules and vocabularies, analysis of semantic types, and extraction of key features (promoters, services, and users). The availability of automated tools for app characterization is important as it may support health care professionals in informed, aware selection of health apps to recommend to their patients.
User-Innovated eHealth Solutions for Service Delivery to Older Persons With Hearing Impairment
Authors: Nielsen Annette Cleveland , Rotger-Griful Sergi , Kanstrup Anne Marie , Laplante-Lévesque Ariane 
Published: November 2018

Purpose
The successful design and innovation of eHealth solutions directly involve end users in the process to seek a better understanding of their needs. This article presents user-innovated eHealth solutions targeting older persons with hearing impairment. Our research question was: What are the key users' needs, expectations, and visions within future hearing rehabilitation service delivery?

Method

We applied a participatory design approach to facilitate the design of future eHealth solutions via focus groups. We involved older persons with hearing impairment (
n
= 36), significant others (
n
= 10), and audiologists (
n
= 8) following 2 methods: (a) human-centered design for interactive systems and (b) user innovation management. Through 3 rounds of focus groups, we facilitated a process progressing from insights and visions for requirements (Phase 1), to app such as paper version wireframes (Phase 2), and to digital prototypes envisioning future eHealth solutions (Phase 3). Each focus group was video-recorded and photographed, resulting in a rich data set that was analyzed through inductive thematic analysis.

Results
The results are presented via (a) a storyboard envisioning future client journeys, (b) 3 key themes for future eHealth solutions, (c) 4 levels of interest and willingness to invest time and effort in digital solutions, and (d) 2 technical savviness types and their different preferences for rehabilitation strategies.

Conclusions
Future eHealth solutions must offer personalized rehabilitation strategies that are appropriate for every person with hearing impairment and their level of technical savviness. Thus, a central requirement is anchoring of digital support in the clients' everyday life situations by facilitating easy access to personalized information, communication, and learning milieus. Moreover, the participants' visions for eHealth solutions call for providing both traditional analogue and digital services.

Supplemental Material

https://doi.org/10.23641/asha.7310729
Intraneural ganglion cysts of the lower limb
Authors: Fricke Tobias , Schmitt Anne Dorothée , Jansen Olav 
Published: November 2018

Background Intraneural ganglion cysts are rare. They affect the peripheral nerves. According to the most widely accepted theory (articular/synovial theory), the cysts are formed from a capsular defect of an adjacent joint, so that synovial fluid spreads along the epineurium of a nerve branch. This leads to diverse neurological symptoms. We will illustrate this disease based on three of our own cases.
Methods Patients were examined between 2011 and 2018 using lower limb MRI. MRI scans were also performed for the follow-up examinations.
Case studies and Discussion The patients had many symptoms. We were able to accurately detect the intraneural ganglion cysts on MRI and provide the treating surgeons with the basis for the operation to be performed. The success of surgical therapy depends on the resection of the nerve endings supplying the joint as the only way to treat the origin of the disease and prevent recurrence. Based on our case studies, we can support the commonly favored articular/synovial theory.
Key Points:

Citation Format
The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans
Authors: Tunjungputri Rahajeng , Li Yang , de Groot Philip , Dinarello Charles , Smeekens Sanne , Jaeger Martin , Doppenberg-Oosting Marije , Cruijsen Milou , Lemmers Heidi , Toenhake-Dijkstra Helga , Aguirre-Gamboa Raul , Kumar Vinod , Wijmenga Cisca , Joosten Leo , Netea Mihai , van der Ven Andre , de Mast Quirijn 
Published: November 2018

Background Inflammation and coagulation are key processes in cardiovascular diseases (CVDs). The Canakinumab Anti-inflammatory Thrombosis Outcome Study trial affirmed the importance of inflammation in CVD by showing that inhibition of the interleukin (IL)-1β pathway prevents recurrent CVD. A bi-directional relationship exists between inflammation and coagulation, but the precise interaction of platelets and IL-1β-mediated inflammation is incompletely understood. We aimed to determine the inter-relationship between platelets and inflammation—and especially IL-1β—in a cohort of healthy volunteers.
Methods We used data from the 500-Human Functional Genomics cohort, which consists of approximately 500 Caucasian, healthy individuals. We determined associations of plasma levels of IL-1β and other inflammatory proteins with platelet number and reactivity, the association of platelet reactivity with ex vivo cytokine production as well as the impact of genetic variations through a genome-wide association study (GWAS).
Results Platelets were associated with IL-1β on different levels. First, platelet number was positively associated with plasma IL-1β concentrations (p = 8.9 × 10−9) and inversely with concentrations of α-1-anti-trypsin (p = 1.04 × 10−18), which is a known antagonist of IL-1β. Second, platelet degranulation capacity, as determined by agonist-induced P-selectin expression, was associated with ex vivo IL-1β and IL-6 production. Third, several platelet single-nucleotide polymorphisms (SNPs) were associated with cytokine production and there was a significant platelet SNP enrichment in specific biological important pathways. Finally, platelet SNPs were enriched among SNPs earlier identified in GWAS studies in blood-related diseases and immune-mediated diseases.
Conclusion This comprehensive assessment of factors associated with platelet number and reactivity reinforces the important inter-relationship of platelets and IL-1β-mediated inflammation.
Fusion of Factor IX to Factor XIII-B Sub-Unit Improves the Pharmacokinetic Profile of Factor IX
Authors: Le Quellec Sandra , Enjolras Nathalie , Perot Eloïse , Girard Jonathan , Negrier Claude , Dargaud Yesim 
Published: November 2018

AbstractProphylaxis is currently considered the optimal care for severe haemophilia. For patients and their families one of the major difficulties with prophylaxis is the need for frequent venipunctures. The half-life of standard factor IX (FIX) concentrates is approximately 18 hours, which requires 2 or 3 intravenous infusions per week to achieve bleeding prevention in patients with severe haemophilia B. Prolonging the half-life of FIX can therefore reduce the frequency of infusions. Recently, extended half-life recombinant FIX (rFIX) concentrates have been developed. We designed a new rFIX molecule fused to coagulation FXIII-B sub-unit. This sub-unit is responsible for the long half-life of the FXIII molecule (10–12 days). The rFIX-LXa-FXIIIB fusion protein contains a short linker sequence cleavable by activated FX (FXa), to separate rFIX from the carrier protein as soon as traces of FXa are generated, leaving rFIX free to perform its enzymatic role in the tenase complex. The rFIX-LXa-FXIIIB fusion protein was expressed in human hepatic Huh-7 cells and Chinese hamster ovary cells, and both wild-type rFIX (rFIX-WT) and rFIX-LXa-FXIIIB showed similar clotting activity and thrombin generation capacity in vivo after injection in haemophilia B mice compared with rFIX-WT. The half-life of the rFIX-LXa-FXIIIB molecule in WT mice and rats was 3.9- and 2.2-fold longer, respectively, compared with rFIX-WT. A potential advantage of this new molecule is its capacity to bind to fibrinogen via FXIII-B, which might accelerate fibrin clot formation and thus improve haemostatic capacity of the molecule.
Abdominal Total Hysterectomy: The Modified Aldridge's Procedure with Noda's Method
Authors: Watanabe Yoh 
Published: November 2018

AbstractAlthough laparoscopic surgery or robotic surgery has recently been the main procedure adopted for managing benign uterine tumors, abdominal total hysterectomy must still be learned as a basic surgical skill for obstetricians and gynecologists. Total hysterectomy is divided into two types: the extrafascial and intrafascial approaches. Intrafascial hysterectomy, represented by the Aldridge's method, is a useful and safe procedure for treatment when the patient has no cervical malignancy, including cervical intraepithelial neoplasia. Furthermore, the intrafascial approach is safely performed even in patients with firm adhesion in the Douglas's pouch and/or around the uterine cervix due to endometriosis, pelvic inflammatory diseases, or a history of intrapelvic surgery. The intrafascial approach can also effectively prevent descent of the vaginal stump after hysterectomy via the partial preservation of the uterine retinaculum. Although the Aldridge's method was originally reported to start via an intrafascial approach at the position of the internal cervical os using scissors, Dr. Kiichiro Noda created a modified version of the procedure that increases its ease and safety by changing the position and management of the parametrial tissue including the uterine artery. The details of this modified Aldridge's procedure using Noda's method are explained below.
Structure Zone Identification as a Geothermal Fluid Path using Gravity Euler Deconvolution-Case Study on Geothermal Area AA
Authors: Armando A. , Daud Y. , Atmojo Jatmiko Prio 
Published: November 2018

Abstract
An Euler deconvolution technique is one of geophysical method for rapidly making depth of anomaly estimated from gravity. Preliminary results from Euler deconvolution of gravity survey (300 meter spacing station) which analyzing on geothermal prospect area, provide confirmation of a structure zone as a geothermal fluid path, such as fault and fracture. In addition, the data allow identification of the location and trend of contact fault that has not been recognized at the surface (satellite mapping). Contact faults can be interpreted from the Euler deconvolution gravity by using SI of 0.0, while dyke use SI of 1.0 and is represented as the boundary of negatif anomaly and positif anomaly on Gravity modelling. The experimental results show that the structure zone distribution of euler deconvolution is localized at a depth of 374 to 579 meters below the surface with a percentage of 59%. Especially, structural zones where are localized near upflow manifestations are at a depth of 374 to 783 meters below the surface, while structural zones where are near outflow manifestations are at a depth of 150 to 570 meters below the surface. This euler deconvolution structures zone are also inline with geology structure
Application of machine learning techniques to tuberculosis drug resistance analysis
Authors: Kouchaki Samaneh , Yang Yang , Walker Timothy M , Sarah Walker A , Wilson Daniel J , Peto Timothy E A , Crook Derrick W ,   CRyPTIC Consortium, Clifton David A 
Published: November 2018

Abstract

Motivation
Timely identification of Mycobacterium tuberculosis (MTB) resistance to existing drugs is vital to decrease mortality and prevent the amplification of existing antibiotic resistance. Machine learning methods have been widely applied for timely predicting resistance of MTB given a specific drug and identifying resistance markers. However, they have been not validated on a large cohort of MTB samples from multi-centers across the world in terms of resistance prediction and resistance marker identification. Several machine learning classifiers and linear dimension reduction techniques were developed and compared for a cohort of 13 402 isolates collected from 16 countries across 6 continents and tested 11 drugs.

Results
Compared to conventional molecular diagnostic test, area under curve of the best machine learning classifier increased for all drugs especially by 23.11%, 15.22% and 10.14% for pyrazinamide, ciprofloxacin and ofloxacin, respectively (P &lt; 0.01). Logistic regression and gradient tree boosting found to perform better than other techniques. Moreover, logistic regression/gradient tree boosting with a sparse principal component analysis/non-negative matrix factorization step compared with the classifier alone enhanced the best performance in terms of F1-score by 12.54%, 4.61%, 7.45% and 9.58% for amikacin, moxifloxacin, ofloxacin and capreomycin, respectively, as well increasing area under curve for amikacin and capreomycin. Results provided a comprehensive comparison of various techniques and confirmed the application of machine learning for better prediction of the large diverse tuberculosis data. Furthermore, mutation ranking showed the possibility of finding new resistance/susceptible markers.

Availability and implementation
The source code can be found at http://www.robots.ox.ac.uk/ davidc/code.php

Supplementary information
Supplementary data are available at Bioinformatics online.
Causes and risk factors for acute dialysis initiation among patients with end-stage kidney disease—a large retrospective observational cohort study
Authors: Arulkumaran Nish , Navaratnarajah Arunraj , Pillay Camilla , Brown Wendy , Duncan Neill , McLean Adam , Taube David , Brown Edwina A 
Published: November 2018

AbstractBackgroundPatients who require acute initiation of dialysis have higher mortality rates when compared with patients with planned starts. Our primary objective was to explore the reasons and risk factors for acute initiation of renal replacement therapy (RRT) among patients with end-stage kidney disease (ESKD). Our secondary objective was to determine the difference in glomerular filtration rate (GFR) change in the year preceding RRT between elective and acute dialysis starts.MethodsWe conducted a single-centre retrospective observational study. ESKD patients either started dialysis electively (planned starters) or acutely and were known to renal services for >90 (unplanned starters) or <90 days (urgent starters).ResultsIn all, 825 consecutive patients initiated dialysis between January 2013 and December 2015. Of these, 410 (49.7%) patients had a planned start. A total of 415 (50.3%) patients had an acute start on dialysis: 244 (58.8%) unplanned and 171 (41.2%) urgent. The reasons for acute dialysis initiation included acute illness (58%) and unexplained decline to ESKD (33%). Cardiovascular disease [n = 30 (22%)] and sepsis [n = 65 (48%)] accounted for the majority of acute systemic illness. Age and premorbid cardiovascular disease were independent risk factors for acute systemic illness among unplanned starts, whereas autoimmune disease accounted for the majority of urgent starts. The rate of decline in GFR was greater in the month preceding RRT among acute dialysis starters compared with planned starters (P < 0.001).ConclusionsCardiovascular disease and advancing age were independent risk factors for emergency dialysis initiation among patients known to renal services for >3 months. The rapid and often unpredictable loss of renal function in the context of acute systemic illness poses a challenge to averting emergency dialysis start.
Relatedness and spatial distance modulate intergroup interactions: experimental evidence from a social rodent
Authors: Deng Ke , Liu Wei , Wang De-Hua 
Published: November 2018

AbstractKin selection theory predicts that individuals should generally behave less aggressively or more amicably towards relatives than nonkin. However, how individuals treat conspecifics depends on genetic relatedness but also on the ecological context, which influences the benefits and costs of their interactions. In this study, we used microsatellite DNA markers and behavioral tests to examine the influence of kinship and proximity on the social behavior of Mongolian gerbils Meriones unguiculatus living in different social groups, and whether these effects varied with sex and season. We recorded the duration of 4 behavioral categories (investigative, neutral, amicable, and agonistic) during a 10-min pairwise test. We found that genetic relatedness had significant effects on the duration of investigative, neutral, and amicable behavior, but not on agonistic behavior. We also found significant interaction effects of relatedness and distance between burrow systems (i.e., spatial distance) on investigative, neutral, and amicable behavior, which suggests that the effects of kinship on social behavior were restricted by spatial proximity. The interaction effect between sex and relatedness on amicable behavior showed that male gerbils became more intimate with individuals of the same sex that had higher pairwise relatedness than females. Furthermore, both male and female gerbils enhanced their aggression during the food-hoarding season, but the intensity of these changes was significantly higher in females. Overall, our results suggest that the effects of kinship and spatial proximity on social behavior exhibit sexual or seasonal patterns, thereby implying ecological context-dependent responses to out-group individuals in Mongolian gerbils.
Educational Note: Paradoxical collider effect in the analysis of non-communicable disease epidemiological data: a reproducible illustration and web application
Authors: Luque-Fernandez Miguel Angel , Schomaker Michael , Redondo-Sanchez Daniel , Jose Sanchez Perez Maria , Vaidya Anand , Schnitzer Mireille E 
Published: November 2018

Abstract
Classical epidemiology has focused on the control of confounding, but it is only recently that epidemiologists have started to focus on the bias produced by colliders. A collider for a certain pair of variables (e.g. an outcome Y and an exposure A) is a third variable (C) that is caused by both. In a directed acyclic graph (DAG), a collider is the variable in the middle of an inverted fork (i.e. the variable C in A → C ← Y). Controlling for, or conditioning an analysis on a collider (i.e. through stratification or regression) can introduce a spurious association between its causes. This potentially explains many paradoxical findings in the medical literature, where established risk factors for a particular outcome appear protective. We use an example from non-communicable disease epidemiology to contextualize and explain the effect of conditioning on a collider. We generate a dataset with 1000 observations, and run Monte-Carlo simulations to estimate the effect of 24-h dietary sodium intake on systolic blood pressure, controlling for age, which acts as a confounder, and 24-h urinary protein excretion, which acts as a collider. We illustrate how adding a collider to a regression model introduces bias. Thus, to prevent paradoxical associations, epidemiologists estimating causal effects should be wary of conditioning on colliders. We provide R code in easy-to-read boxes throughout the manuscript, and a GitHub repository [https://github.com/migariane/ColliderApp] for the reader to reproduce our example. We also provide an educational web application allowing real-time interaction to visualize the paradoxical effect of conditioning on a collider [http://watzilei.com/shiny/collider/].
Highland Romance or Viking Saga?
Authors: Pedersen Sarah , Peach Andrea 
Published: November 2018

Abstract
Few have heard of Orkney tweed today, but in the mid-twentieth century it was as well known as Harris Tweed, and praised for its soft and light characteristics. This article investigates the rise and fall of Orkney tweed and suggests that its decline in the 1960s can be attributed to a variety of factors, including the advent of synthetic, ready-to-wear clothing, but also problems inherent in the mixed marketing messages around the textile. While the main producers of Orkney tweed emphasized the Viking connections of the Orkney islands and their product, the fashion media and overseas customers were more comfortable with positioning Orkney tweed within a stereotypic context of Scottish romanticism, in which Orkney tweed became interchangeable—and replaceable—with all Scottish tweeds. Contemporary attempts to re-establish tweed production on the Orkney Islands have rejected both approaches, focusing instead on the ‘natural’ properties of the fabric and the production of easily portable souvenirs.
‘Covetable pictures’
Authors: Busciglio-Ritter Thomas 
Published: November 2018

Abstract
Born in 1820, John Taylor Johnston is a pivotal figure in the history of American collecting. A pioneer in transatlantic art collecting, his numerous visits to Europe helped him develop his taste, enrich his possessions, and build a reliable network of artists and dealers. He then re-injected this experience into a rising New York art market, becoming the first collector to enjoy success through the weekly public opening of a domestic art gallery. Here he displayed his highly-praised collection of European and American paintings, comprising works by Vernet, Gérôme, Meissonier, Homer and Church. Along with his brother James, Johnston also founded the very first edifice in the United States devoted entirely to housing artists – the Tenth Street Studio Building, designed by architect Richard Morris Hunt. His reputation as a collector eventually led to his appointment as first president of the newly formed Metropolitan Museum in 1871.