bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin Protein which Serves as a Virulence Factor
Authors: Finka Regina , Agustina Dini , Rachmawati Dwita Aryadina , Suswati Enny , Mufida Diana Chusna , Shodikin Ali 
Published: July 2019

Klebsiella pneumoniae is an infectious bacteria in various parts of the body. The presence of proteins in pili that will bind to cell surface receptors (adhesin proteins) and cell membrane sugar molecules (hemagglutinin proteins) is a very influential factor in the ability of K. pneumoniae to enter the human body. The purpose of this study was to determine the role of pili 38.6 kDa K. pneumoniae protein as a hemagglutinin and adhesin protein which functions as a virulence factor. This type of research is pure experimental research using the electrophoresis method (SDS-PAGE) to obtain protein. The protein obtained was then tested for hemagglutination and adhesion test using erythrocyte cells and enterocytes of BALB / C mice to determine their role as hemagglutinin and adhesin proteins. Conclusion of this study pili protein 38.6 kDa Klebsiella pneumoniae acts as a hemagglutinin and adhesion protein which functions as a virulence factor.
Keywords: Klebsiella pneumonia, 38,6 kDa Protein, Hemagglutinin, Adhesin
PROPERTY PRICE BUBBLE: REGIONAL ANALYSIS IN INDONESIA
Authors: Kurniawan Indra 
Published: July 2019

The aim of this study is to look at the influence of fundamental factors of demand and supply side of the property prices in five major Cities in Indonesia using data panel regression methods. In addition, this study analyzes the regional property and the price bubble in Indonesia using the Hodrick Prescott filter analysis. The results of the panel data regression method Showed that the demand-side fundamentals such as economic growth and inflation have a positive effect on property prices as well as interest rate, while the loan to value(LTV) Negatively Affect the price of the property. On the other hand, the fundamental factors of supply-side variable, that is developer’s price expectations impact positively the price of the property. HP filter analysis identifying the bubble in every city that lasted for two periods during the study.
Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling
Authors: Wanhainen Kelsey M. , Jameson Stephen C. , da Silva Henrique Borges 
Published: July 2019

AbstractFollowing activation, CD8 T cells transition from reliance on mitochondrial respiration to increasing utilization of aerobic glycolysis. After the effector phase, however, reversion to mitochondrial metabolism is pivotal generating memory CD8 T cells. We recently showed that sensing of extracellular ATP (eATP) through the receptor P2RX7 is crucial for both production and the long-term survival of memory CD8 T cells, evidently through promoting mitochondrial maintenance. Unexpectedly, these results indicated that sustained P2RX7 activation is required for memory CD8 T cell homeostasis, suggesting constant exposure to eATP, in contrast with the proposed role of eATP as an acute "danger" signal released by dying cells. Active release through transmembrane channels is another path for eATP export. Indeed, CD8 T cells express Pannexin 1 (Panx1) which has a reported eATP release functionin vitroand is itself induced by P2RX7 and/or TCR engagement. Such a role for Panx1 could potentially provide a feed-forward mechanism for cell-autonomous P2RX7 signaling. This model envisages that memory CD8 T cells maintain themselves at the cost of reduced intracellular ATP levels, which at first glance would seem to be detrimental for sustained T cell maintenance. On the other hand, the need to tightly regulate levels of intracellular ATP may be critical for the durability and adaptability of memory CD8 T cells, hence engagement of the P2RX7/Panx1 axis may allow these cells to fine tune their metabolic status to meet changing demands. In this Perspective, we discuss how this pathway may influence memory T cell maintenance.
THE EFFECTS OF SOCIAL FACTORS ON THE ADOPTION OF RICE PRODUCTION TECHNOLOGIES IN ZONE C OF BENUE STATE, NIGERIA
Authors: Ejembi S A , F Orkpe , G.O Bello 
Published: July 2019

AbstrakPenduduk Nigeria seperti pada bagian lain dunia terus melambung sehingga memerlukan peningkatan produktivitas pertanian dan ketahanan pangan. Untuk memenuhi kebutuhan pangan, perlu dilakukan peningkatan produksi melalui teknologi yang tepat. Di sebagian besar wilayah Nigeria, adopsi teknologi pertanian masih rendah. Penelitian ini bertujuan untuk menganalisa pengaruh karakteristik sosial petani terhadap keputusannya mengadopsi teknologi produksi padi. Penelitian dilakukan di Zona C dari Negara Bagian Benue yang dipilih secara purposif karena di daerah ini tersedia areal pertanian yang sesuai untuk pertanaman padi. Seratus responden dipilih melalui teknik simple random sampling. Statistik deskriptif (persentase dan frekuensi) dan statistik inferensial (Model Regresi Biner Logit) digunakan untuk analisis data. Hasil penelitian menunjukkan bahwa mayoritas reponden (55%) adalah laki-laki, 48% memiliki pengalaman bertani antara 6-20 tahun, 49% memiliki kualifikasi pendidikan tersier, 62% bukan berasal dari kelompok tani, 51% tidak memiliki kontak dengan penyuluh dan 56 % responden memperkirakan pendapatan tahunan mereka rata-rata ₦ 120, 000.00. Pada umumnya responden memperoleh informasi pertanian utama melalui radio, 93% mengungkapkan bahwa teknologi benih merupakan teknologi utama yang tersedia bagi petani. Hasil regresi logit menunjukkan bahwa pendidikan (W = 9.600), dan luas lahan (W = 2.051) secara signifikan mempengaruhi keputusan adopsi petani. Berdasarkan temuan ini, disimpulkan bahwa tingkat adopsi yang rendah karena tidak adanya teknologi baru selain benih yang lebih baik, dan juga tidak adanya penyuluhan. Oleh karena itu, direkomendasikan agar organisasi petani diperkuat agar mereka dapat mengatur layanan penyuluhan mereka sendiri. Kata Kunci: adopsi teknologi; faktor sosial; teknologi baru; penyuluhan pertanian
RESPON PETANI TERHADAP PELAKSANAAN DISPLAI PADI GOGO VUB PADA LAHAN SUB OPTIMAL DI SULAWESI SELATAN
Authors: Sunanto Sunanto , Rauf Abd Wahid 
Published: July 2019

RESPON PETANI TERHADAP PELAKSANAAN DISPLAI PADI GOGO VUB PADA LAHAN SUB OPTIMAL DI SULAWESI SELATAN Farmers Response on VUB “Gogo” Rice Display on Sub-Optimal Landin South Sulawesi Sunanto * dan Abd. Wahid Rauf Balai Pengkajian Teknologi Pertanian (BPTP) Sulawesi Selatan *Kontak penulis: sunanto_bptpsulsel@yahoo.co.id The Gogo rice is a food crop that contributes to food self-sufficiency. Food demand, especially rice continues to increase along with population growth. Because of the higher food needs and the narrowness of fertile land, due to the land conversion function. So the utilization of sub-optimal lands / landed with appropriate food crops. The potency of thesub-optimal area in South Sulawesi is 274,549 hectares. The purpose of this research is to know how sub-optimal land used and farmer appraisal to gogo rice. This research was conducted in Wajo and Jeneponto Regencies from January to December 2017. The research used survey method and display of gogo rice plant NSV of Agricultural Research Agency in the field. The number of farmers taken as a sample of 80 farmers.The technique of collecting data by interview method and observation of vegetative and generations of display gogo rice plant. The collected data are then tabulated and then analyzed descriptively and test the agreement and business feasibility. The activities of rice farming on sub-optimal land are done by farmers that have the productive age. Theapplication of rice farming technology to suboptimal land has not been intensive yet. Display gogo rice plant VUB resulted from Agricultural Research Agency appropriate to be planted with / out sub-optimal land of dry land and irrigated rice fields limited. Understanding farmers on superior gogo rice are not optimal (77.50%). Farmer's preference to superior gogo farmers. Rice farming of farmers provides income(implicative). Rp 4.575.000/ha, (explicit). Rp 7.245.000/ha and R/C (implicative ) 1.62 and (explicit ) 2.53.Keywords: upland rice; VUB; land; sub optimal.
NILAI BUDAYA PADA SISTEM USAHATANI POLA ‘DUSUN’ SUKU KANUM DI KAMPUNG YANGGANDUR KABUPATEN MERAUKE
Authors: Susanty Puji , Musa Yunus , Rahmadanih Rahmadanih , Bulkis Sitti 
Published: July 2019

­­NILAI BUDAYA PADA SISTEM USAHATANI POLA ‘DUSUN’ SUKU KANUM DI KAMPUNG YANGGANDUR KABUPATEN MERAUKE The Cultural Values on ‘Dusun’ Pattern Farming System of The “Kanum” Tribe in Yanggandur Village Merauke Regency Puji Susanty*, Yunus Musa, Rahmadanih, Sitti Bulkis *Politeknik Pertanian Yasanto, Merauke (email: pujisusanti74@gmail.com) Abstract“Dusun” is a specific area of the traditional land in Kanum Tribe, which been chosen as place for farmer to cultivated as rural areas for families or in Kanum Tribes Group Society that been inherite from generation to generation. This research aimed to describe the cultural values in managing the farming system of “dusun” pattern carried out by indigenous community of Kanum Tribe. The research was conducted in Yanggandur Village, Merauke Regency. Qualitative approach and snowball sampling method were applied to collect the data through interviews from informants. In order to analyze the data it applied data reduction techniques, presentation and conclusion as well as verification. From the research, it was indicated that the prime food crop that cultivated by Kanum Tribe in the “dusun” are ‘kumbili’. The Kanum Tribe still actively managed the farming system of “dusun” pattern because the “kumbili” farming system contained the cultural values which they had inherited from generation to generation. The cultural values contained in “kumbili” cultivation were the safety and religious value, the wisdom and mutual cooperation value, and the responsibility value.Keywords: cultural value; “dusun” pattern farming; Kanum Tribe.
Halal Food di Era Revolusi Industri 4.0: Prospek dan Tantangan
Authors: Zahrah Aminatuz , Fawaid Achmad 
Published: July 2019

Teknologi yang semakin canggih membuat beberapa teknologi kecerdasan buatan mulai bermunculan di segala aspek, termasuk dalam industri makanan halal. Tulisan ini berupaya untuk mengetahui bagaimana Industri makanan halal di era Revolusi Industri 4.0? Apa dampak Revolusi Industri 4.0 terhadap keberadaan makanan halal di Indonesia? Pada era Revolusi Industri 4.0, pebisnis sangat mudah dalam mengelola makanan halal baik proses maupun penjualanya yakni melalui mesin kompleks, laboratorium lengkap, modern halal valley, alat dan aplikasi kecerdasan buatan. Semua ini berdampak terhadap keberadaan makanan halal di Indonesia yang semakin terkenal, penjualannya yang lebih efisien dan lebih luas, proses pemesanan dan produksi yang lebih efektif, pembaruan menu yang lebih cepat, dan pasar yang lebih terbuka, sehingga industri makanan halal pun semakin dituntut untuk memiliki daya saing.
Post-operative Orthopedic Infection with Monomicrobial Leclercia adecarboxylata
Authors: Mayfield Cory K. , Haglin Jack M. , Konda Sanjit R. , Tejwani Nirmal C. , Egol Kenneth A. 
Published: July 2019

Case:An 65-year-old immunocompetent female developed aLeclercia adecarboxylatainfection following the repair of closed olecranon fracture.L. adecarboxylatais associated with polymicrobial infections, infections in immunocompromised patients and penetrating or open wounds. Following speciation, intravenous ceftriaxone was started. Two weeks later, the patient presented with leukopenia and neutropenia. Per infectious disease recommendations, the patient was switched to intravenous ertapenem with resolution of both infection and neutropenia. The olecranon fracture went on to heal fully.Conclusions:This case describes a rare postoperative monomicrobial infection withL. adecarboxylatain an immunocompetent host following musculoskeletal trauma and identifiesL. adecarboxylataas a potential emerging hospital-acquired pathogen following orthopedic surgery.
Team Approach: Modern-Day Prostheses in the Mangled Hand
Authors: Delarosa Matthew , Gaston R. Glenn , Loeffler Bryan , Monroe Brian , Rumfelt Stacy 
Published: July 2019

» Early prosthesis fitting enhances prosthesis acceptance and utilization.» Establishing a relationship early with the team can improve surgical planning and expedite postoperative care.» Targeted muscle reinnervation performed in the acute phases of care can greatly improve neuroma pain control and prosthesis functionality.» There is a high rate of mental health issues at various times during treatment. A high suspicion for these problems is paramount in effective treatment.» Peer-driven support has been instrumental in successful recovery in these devastating injuries.
Surgical Management of the Spastic Forearm, Wrist, and Hand: Evidence-Based Treatment Recommendations
Authors: Rhee Peter Charles 
Published: July 2019

» The surgical approach for the patient with a spastic upper limb must be individualized and goal-focused.» An injury to the central nervous system can lead to spinal reflex hyperexcitability with exaggerated muscle activation in response to quick stretch stimuli (i.e., spasticity).» Surgical treatment options are dependent on the potential for function in the spastic upper limb.» If volitional motor control is present, spastic motor units can be lengthened or released while preserving function.» In the absence of volitional motor control, spastic muscles can be divided, released, or denervated with selective neurectomies.
Genetic diversity and population structure of black cottonwood (Populus deltoides) revealed using simple sequence repeat markers
Authors: Chen Cun , Chu Yanguang , Ding Changjun , Su Xiaohua , Huang Qinjun 
Published: July 2019

Abstract
Background: Black cottonwood (Populus deltoides) is one of the keystone forest tree species, and has become the main breeding parents in poplar hybrid breeding. However, the genetic diversity and population structure of the introduced resources are not fully understood.
Results: In the present study, five loci containing null alleles were excluded and 15 pairs of SSR (simple sequence repeat) primers were used to analyze the genetic diversity and population structure of 384 individuals from six provenances of P. deltoides. Ultimately, 108 alleles (Na) were detected; the expected heterozygosity (He) ranged from 0.070 to 0.905, and the average locus polymorphic information content (PIC) was 0.5354. The provenance ‘Was’ had the lowest genetic diversity, while ‘Que’, ‘Lou’, and ‘Ten’ provenances had high genetic diversity, with Shannon's information index (I) above 1.0. The mean coefficient of genetic differentiation (Fst) and gene flow (Nm) were 0.129 and 1.931 respectively. Analysis of molecular variance (AMOVA) showed that 84.88% of the genetic variation originated from individuals. Based on principal coordinate analysis (PCoA) and STRUCTURE cluster analysis, clones distributed in Mississippi River Basin were roughly classified as one group, while those distributed in the St. Lawrence River Basin and Columbia River Basin were classified as another group. The cluster analysis based on the population level showed that provenance ‘Iow’ had a smaller gene flow and higher degree of genetic differentiation compared with the other provenances, and was classified into one group. There was no significant relationship between genetic distance and geographical distance.
Conclusions: P. deltoides resources have high genetic diversity and there is a moderate level of genetic differentiation among provenances. Geographical isolation and natural conditions may be the main factors causing genetic differences among individuals; however, the genetic variation among provenances has no clear correlation with their geographical locations. Clones reflecting population genetic information can be selected to build a core resource bank, which could provide effective protection and promote the scientific utilization of the P. deltoids resource, laying a solid foundation for poplar breeding.
Mortality Predicted by different Hematological Malignancy types, Bacteremia, and Lack of Chemotherapy at Kinshasa University Clinics
Authors: LONGO-MBENZA Benjamin , Nkanga Mireille Solange Nganga , Matoumona Yolande Voumbo , Mokondjimobe Etienne , Abena Ange Antoine , Silou Jacques , Ngwidiwo Jacques Bikaula 
Published: July 2019

Abstract
Objective To identify environmental, pollutant metals, epidemiological, clinical, therapeutic, and able to predict case fatality among patients with anemia and hematological malignancy (HM). Methods This was a retrospective cohort study in black patient’s ≥ 20 years managed for recurrent fever, infections, anemia, and bacteremia between 2009 and 2015 at Kinshasa University Clinics, DRC. The outcomes such as incident HM and case fatality were assessed using univariate means, standard errors, relative risk (RR) and multivariate proportional Hazard ratio (HR) by Cox regression analysis, while Log-Rank test was performed for comparisons by Kaplan Meier curves (means, 95% CI, and median survival). Results Out of 105 incident HM patients (Male: Female ratio = 1), 57.1% (n= 60) experienced case fatality, There was no association between gender, residence, ethnicity, fever and mortality. There was a significant univariate association between age ≥ 55 years, serum chromium, serum cadmium, serum iodine, serum mercury, rainy season, hemolytic anemia, HM, bone pain, elevated Erythrocyte sedimentation, splenomegaly, abdominal pain, neutropenia, El Nino years, combined local dry season + global climate variability/El Nino, thrombocytopenia, multi-transfusions, bacteremia, lack of chemotherapy, and mortality. After adjusted for confounders using Cox regression models, only incident HM (HR = 16.8; 95% CI, P< 0.0001), Lack of chemotherapy (HR = 6.9, 95% CI, P< 0.002), and Bacteremia (HR= 4.2; 95% CI, P= 0.020) were the most significant and independent predictors of mortality. A separate analysis for HM patients, the mortality rates did not vary (P> 0.05) across HM sub-types: 71.4% (n= 10/14) in multiple myeloma, 84.3% (n= 15/18) in acute myeloid leukemia, 70% (n= 7/10) in myelodysplastic syndromes, 80% (n= 8/10) in chronic myeloid leukemia, 33.3% (n= 2/6) in acute myeloid leukemia, and 80% (n= 4/5) in acute lymphoid leukemia. Conclusion HM is a major cause of morbidity and mortality with epidemic rates explained by lack of chemotherapy, and recurrent bacteremia among Bantu patients facing aging, climate change, rainy seasons, and lack of palliative care.
Imidafenacin, a novel antimuscarinic agent, is alternative to antimuscarinic agents in patients with overactive bladder syndrome:An updated systematic review and Meta-analysis of randomized controlled trials
Authors: Wu Jia-Pei , Peng Liao , Zeng Xiao , Li Hao , Shen Hong , Luo De-yi 
Published: July 2019

Abstract
Purpose

Previous study included limited number of randomized controlled trials (RCTs) and compared limited parameters post the treatment of imidafenacin and other anticholinergic drugs (ADs) for overactive bladder syndrome (OAB) and controversy about the superiority of those ADs still remains. We aim to update the evidence and provide better clinical guidance.

Methods

A systematic search in PubMed, Embase, ClinicalTrial.gov, and Cochrane Library Central Register of Controlled Trials was conducted from January 2007 to April 2019. Meta-analysis of all published RCTs comparing imidafenacin with other ADs in patients with OAB was performed. The primary outcomes were the changes in OAB symptoms and OAB Symptom Score (OABSS). Secondary outcomes included adverse events (AEs) and dropout rate related to AEs.

Results

A total of 6 studies including 7 RCTs involving 1,430 patients with mean follow-up of 23.43 weeks were included. All ADs improved OAB symptoms. In regard to efficacy, those drugs had similar efficacy in voids, urgency episodes, urgency incontinence episodes, incontinence episodes and in OABSS. However, Imidafenacin had a better performance in the reduction of nocturia episodes (MD=-0.24, 95%CI -0.44 to-0.04, P=0.02). Moreover, Imidafenacin was associated with statistically lower dry mouth rate (RR=0.87, 95%CI 0.75-1.00, P=0.04), lower constipation rate (RR=0.68, 95%CI 0.50-0.93, P=0.01) and lower AE-related withdrawal rate (RR=0.51, 95%CI 0.29-0.89, P=0.02). There was no significant difference in terms of other complications.

Conclusions

In conclusion, Imidafenacin was comparable with other ADs in the treatment of OAB. Moreover, imidafenacin presented lower dry mouth rate, lower constipation rate and higher adherence and persistence.
The effect of internal limiting membrane peeling to normal retinal function evaluated by microperimetry-3
Authors: Qi Yue , Wang Zengyi , You Qisheng , Liang Xida , Yu Yanping , Liu Wu 
Published: July 2019

Abstract
Background

To evaluate the effect of internal limiting membrane (ILM) peeling to the function of retina surrounding macular holes (MH) by microperimetry-3(MP-3).

Methods

This is a prospective, cohort study which included 44 eyes of 44 patients with MHs who were treated by 23-gauge 3-port pars plana vitrectomy and ILM peeling with air tamponade. Color fundus photography, retinal optical coherence tomography and MP-3 were used 1 week before and 1, 4 months after operation. In MP-3 examination, a customized follow-up pattern with 45 spots in the central 8° visual field was used. The spots corresponding to the retina surrounding macular holes were selected for comparison of pre- and post-operative function. Results All eyes had achieved an anatomical success at the last follow-up. BCVA (logMAR) significantly improved both in 1 and 4 months after surgery (1.06±0.40 versus 0.53±0.30 and 0.31±0.24, P<0.01). The mean retinal sensitivity (MRS) (in dB) of the retina surrounding macular hole significantly increased 1 and 4 months after ILM peeling: pre-operative 23.46±3.01 dB versus post-operative 26.25±2.31 dB (u=-4.88, P<0.01) in 1 month and 27.14±2.45 dB (t=-6.29, P<0.01) in 4 months. Patients with increased MRS are significantly younger than patients with deceased MRS (59.72±3.22 years versus 65.60±8.19 years, P<0.01). After ILM peeling, the increasing extent of MRS was significantly higher in inferior and nasal retina than that in superior and temporal retina both in 1 and 4 months (P<0.05).

Conclusion

ILM peeling in normal retina will not decrease the retinal function in a short-term after surgery.