bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating β1 Adrenergic Autoantibodies from Patients with Chronic Periodontitis Interact with Gingival Fibroblasts
Authors: Sterin-Borda Leonor , Furlan César , Borda Enri 
Published: September 2019

ABSTRACTObjectives: To demonstrate the presence of circulating autoantibodies (Abs) from patients with chronic periodontitis (CP) that interacted with human gingival fibroblast membranes activating β1 adrenoceptors (β1-AR).Methods: Sera and purified IgG from 25 patients with CP and 20 age-matched healthy subjects were studied by flow cytometry, ELISA and DNA synthesis. Human gingival fibroblast membranes and/or synthetic peptides with amino acid sequences identical to human β1-AR were used as antigens.Results: By flow cytometry and ELISA procedures, we proved that the serum-purified IgG fraction from patients with CP reacted with the fibroblast surface and to the β1 synthetic peptide. The corresponding affinity-purified anti-β1 peptide Abs displayed agonist-like activity associated with specific receptor activation, inhibiting the DNA synthesis of human gingival fibroblasts.Conclusions: This study demonstrates that β1-AR autoantibodies are elevated in patients with CP. These autoantibodies were targeted to the fibroblasts, and specifically to the β1-AR, and has receptor-like activity inhibiting DNA synthesis. (Eur J Dent 2009;3:191-199)
Unusual Synchronous Presentation of Maxillary Sinus Fibrosarcoma and Gemistocytic Astrocytoma with a Complication Called Leukocytoclastic Vasculitis: A Case Report
Authors: Cadir Bilge , Karahan Nermin , Nasir Serdar , Aydin M. Asim , Turkaslan S.Suha 
Published: September 2019

ABSTRACTFibrosarcoma of the paranasal sinuses is extremely rare pathology and there is limited report in the literature. We report synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma which is, to our knowledge, unique in the literature. Both tumors metastases to other organ rarely and the metastatic spread of gemistocytic astrocytoma to fibrosarcoma or vice versa have also not been reported in the literature yet. This report discusses the clinical course of the disease, outcome of the treatment approach and survival as well as an unusual occurrence of leukocytoclastic vasculitis during the course of radiotherapy in such unusual presentation. (Eur J Dent 2009;3:233-239)
A New Form of Intraoral Delivery of Antifungal Drugs for the Treatment of Denture-Induced Oral Candidosis
Authors: Amin Wala M. , Al-Ali Muna H. , Salim Nesreen A. , Al-Tarawneh Sandra K. 
Published: September 2019

ABSTRACTObjectives: To monitor the release of the antifungal drugs Fluconazole, Chlorhexidine and a combination of the two from an auto-polymerized poly (methyl methacrylate) (PMMA) denture base resin; and to investigate the effect of the released drugs upon the growth of Candida albicans.Methods: A high performance liquid chromatography-Ultra violet (HPLC-UV) method was used in the analysis of the released drugs into distilled water from PMMA discs doped with the antifungal drugs Fluconazole (10%), Chlorhexidine (10%) and a combination of the two drugs (5% each). The antifungal efficacy of the released drugs was monitored, microbiologically, employing “well” technique on a Saborauds culture medium inoculated with a resistant strain of Candida albicans.Results: It was shown that Fluconazole, Chlorhexidine and the combination of the two drugs can be successfully incorporated with PMMA. It was found that the drugs leach steadily out of the PMMA resin into distilled water at mouth temperature and that sustained drug release continued throughout the 28 days test period. It was also shown that the released drugs demonstrated an antifungal activity against the resistant Candida albicans and this was most remarkable in the combined drugs samples.Conclusions: The findings of this investigation have a clinical value in terms of their significant contribution to the treatment of fungal infections of the oral cavity. The sustained release of antifungal drugs from the PMMA resin clearly constitutes a new dosage form of these drugs via the poly (methyl methacrylate) delivery system. (Eur J Dent 2009;3:257-266)
Water Absorption and HEMA Release of Resin-Modified Glass-Ionomers
Authors: Beriat Nilufer Celebi , Nalbant Dilek 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to evaluate the water absorption and the amount of hydroxyethyl metacrylate (HEMA) level released from various resin modified glass ionomer cements.Methods: Advance, Vitremer and Protec-Cem resin modified glass ionomer cements were used to evaluate the HEMA release. Ten specimens were fabricated from each cement in 10 × 1 mm height. Thirty specimens were immersed in glass containers filled with 20 ml deionized water. 1 ml solution was taken from the container at 10 minutes, 1 hour, 24 hour and 7 days intervals from each group and analyzed with high performance liquid chromatography (HPLC) machine and the results are presented in ppm. The data were subjected to Kruskal-Wallis, Mann-Whitney and Wilcoxon tests at a 0.05 significance level.Results: At all time intervals Vitremer showed highest HEMA release (10 min: 54.2 ppm; 1 h: 86.8 ppm; 24 h: 93.4 ppm) (P=0.0001). At the end of 10 minutes and first hour, following Vitremer, HEMA release was highest for Protec-Cem (10 min: 14.8 ppm; 1 h: 23.6 ppm) and then Advance (10 min: 5.5 ppm; 1 h: 18.8 ppm) (P<.05). Water absorption tests were performed according to the specifications of ISO 4049. Water absorption was highest for Vitremer and lowest for the Protec-Cem and the difference among cement groups was significant (P<.005).Conclusions: Vitremer showed the highest HEMA release and water absorption values and Protec-Cem showed the lowest values. HEMA release by time was significant for Advance cement. This
release may be relevant both to the risk of adverse pulpal responses in patients and to the risk of allergy in patients and dental personnel. (Eur J Dent 2009;3:267-272)
Incidence of Postoperative Pain after Single- and Multi-Visit Endodontic Treatment in Teeth with Vital and Non-Vital Pulp
Authors: Ince Bayram , Ercan Ertugrul , Dalli Mehmet , Dulgergil Coruh Turksel , Zorba Yahya Orcun , Colak Hakan 
Published: September 2019

ABSTRACTObjectives: To assess the incidence of postoperative pain after single- and multi-visit endodontic treatment of teeth with vital and non-vital pulp.Methods: In total, 306 patients with teeth requiring endodontic treatment were identified and were included in this study. Two experienced clinicians treated the patients, who were randomly assigned to two groups. While the teeth of patients in group 1 were obturated, group 2 were temporarily sealed and obturated after one week. Three days after the root canal instrumentation of each tooth, the patients were asked whether they experienced any postoperative pain and to rate the level of discomfort as no, mild, moderate, or severe pain. Data were analyzed statistically using the chisquare test.Results: No significant difference in postoperative pain was found between vital and non-vital teeth (P>.01). Mild, moderate, and severe pain occurred in 31.4, 13.7, and 4.6% of vital teeth, respectively. Postoperative pain occurred in 107 (69.9%) and 106 (69.3%) teeth in the single- and multi-visit treatment groups, respectively. There was no significant difference in postoperative pain between the two groups (P>.01).Conclusions: The prevalence of postoperative pain did not differ between vital and non-vital teeth. The majority of patients in either groups reported no or only mild pain. (Eur J Dent 2009;3:273-279)
Biopure MTAD Induces DNA Damage but Not Cellular Death: An In Vitro Study
Authors: Marins Juliana Soares Roter , Sassone Luciana Moura , Ribeiro Daniel Araki 
Published: September 2019

ABSTRACTObjectives: The purpose of this study was to evaluate the capacity of BioPure MTAD to induce genetic damage in vitro. Genotoxicity was assessed by the single cell gel (comet) assay.Methods: Chinese hamster ovary (CHO) cells or murine fibroblasts cells were exposed to increasing final concentrations ranging from 0.1 a 10%. All treatments were performed for 1 hour at 37°C. The negative control group was treated with vehicle control (phosphate buffer solution - PBS) for 1 hour at 37°C and the positive control group was treated with methylmetanesulfonate (at 1 µM) for 1 hour at 37°C.Results: Present results showed that the BioPure MTAD was able to promote DNA breakage in
CHO cells only at the highest concentration tested as well as to induce significant increase in tail moment at all tested concentrations in murine fibroblasts.Conclusions: In summary, our results indicate that BioPure MTAD is a genotoxic agent as depicted by the single cell gel (comet) assay. (Eur J Dent 2009;3:285-289)
Treatment of Gingival Recessions Associated to Cervical Abrasion Lesions with Subepithelial Connective Tissue Graft: A Case Report
Authors: Deliberador Tatiana M. , Bosco Alvaro F. , Martins Thiago M. , Nagata Maria J. H. 
Published: September 2019

ABSTRACTExtensive gingival recessions associated with cervical abrasions are common among the population. Several different surgical and/or restorative therapies have been proposed to correct these lesions. This manuscript reports the treatment of multiple gingival recessions associatedto cervical abrasions. The procedure involved the utilization of subepithelial connective tissue graft (SCTG) combined with coronally advanced flap onto a previously restored root surface. At the postoperative follow-up visits, the success of the restorative/surgical approach was confirmed by the absence of bleeding to probing and periodontal pockets as well as presence of gingival tissue with normal color, texture and contouring. After 18 months of follow-up, the clinical conditions are stable with satisfactory root coverage and periodontal health. An excellent esthetical outcome was achieved and the patient is satisfied with case resolution. (Eur J Dent 2009;3:318-323)
Image Post-Processing in Dental Practice
Authors: Gormez Ozlem , Yilmaz Hasan Huseyin 
Published: September 2019

ABSTRACTImage post-processing of dental digital radiographs, a function which used commonly in dental practice is presented in this article. Digital radiography has been available in dentistry for more than 25 years and its use by dental practitioners is steadily increasing. Digital acquisition of radiographs enables computer-based image post-processing to enhance image quality and increase the accuracy of interpretation. Image post-processing applications can easily be practiced in dental office by a computer and image processing programs. In this article, image post-processing operations such as image restoration, image enhancement, image analysis, image synthesis, and image compression, and their diagnostic efficacy is described. In addition this article provides general dental practitioners with a broad overview of the benefits of the different image post-processing operations to help them understand the role of that the technology can play in their practices. (Eur J Dent 2009;3:343-347)
Obesity, Second Stage Duration, and Labor Outcomes in Nulliparous Women
Authors: Frolova Antonina I. , Raghuraman Nandini , Stout Molly J. , Tuuli Methodius G. , Macones George A. , Cahill Alison G. 
Published: September 2019

Abstract
Objective This study aimed to estimate second stage duration and its effects on labor outcomes in obese versus nonobese nulliparous women.
Study Design This was a secondary analysis of a cohort of nulliparous women who presented for labor at term and reached complete cervical dilation. Adjusted relative risks (aRR) were used to estimate the association between obesity and second stage characteristics, composite neonatal morbidity, and composite maternal morbidity. Effect modification of prolonged second stage on the association between obesity and morbidity was assessed by including an interaction term in the regression model.
Results Compared with nonobese, obese women were more likely to have a prolonged second stage (aRR: 1.48, 95% CI: 1.18–1.85 for ≥3 hours; aRR: 1.65, 95% CI: 1.18–2.30 for ≥4 hours). Obesity was associated with a higher rate of second stage cesarean (aRR: 1.78, 95% CI: 1.34–2.34) and cesarean delivery for fetal distress (aRR: 2.67, 95% CI: 1.18–3.58). Obesity was also associated with increased rates of neonatal (aRR: 1.38, 95% CI: 1.05–1.80), but not maternal morbidity (aRR: 1.06, 95% CI: 0.90–1.25). Neonatal morbidity risk was not modified by prolonged second stage.
Conclusion Obesity is associated with increased risk of neonatal morbidity, which is not modified by prolonged second stage of labor.
The Association between Maternal Race and Ethnicity and Risk Factors for Primary Cesarean Delivery in Nulliparous Women
Authors: Stark Elisabeth L. , Grobman William A. , Miller Emily S. 
Published: September 2019

Abstract
Objective To understand whether maternal, perinatal, and systems-level factors can be identified to explain racial/ethnic disparities in cesarean delivery rates.
Study Design This retrospective cohort study included nulliparous women with singleton gestations who delivered at a tertiary care center from 2015 to 2017. Maternal, perinatal, and systems-level factors were compared by race/ethnicity. Multilevel multivariable logistic regression was used to identify whether race/ethnicity was independently associated with cesarean. Effect modification was evaluated using interaction terms. Bivariable analyses and multinomial logistic regression were used to determine differences in indication for cesarean.
Results Of 9,865 eligible women, 2,126 (21.5%) delivered via cesarean. The frequency of cesarean was lowest in non-Hispanic white women (19.2%) and highest in non-Hispanic black women (28.2%; p < 0.001). Accounting for factors associated with cesarean delivery did not lessen the odds of cesarean associated with non-Hispanic black race (aOR: 1.58, 95% CI: 1.31–1.91). Compared with non-Hispanic white women, non-Hispanic black women were more likely to undergo cesarean for nonreassuring fetal status (aOR: 2.73, 95% CI: 2.06–3.61).
Conclusion Examined maternal, perinatal, and systems-level risk factors for cesarean delivery did not explain the racial/ethnic disparities observed in cesarean delivery rates. Increased cesarean delivery for nonreassuring fetal status contributed substantially to this disparity.
Risk of Stillbirth after Antepartum Hospitalization for Hypertensive Diseases of Pregnancy
Authors: Wen Timothy , Breslin Noelle , Overton Eve E. , Turitz Amy L. , D'Alton Mary E. , Attenello Frank , Mack William J. , Friedman Alexander M. 
Published: September 2019

Abstract
Objective To determine if women with an antepartum admission for hypertensive diseases of pregnancy (HDP) were at increased risk for stillbirth.
Study Design This study utilized the 2010 to 2014 Nationwide Readmissions Database. Antepartum admissions with HDP were identified and linked to subsequent delivery hospitalizations. Delivery hospitalizations with HDP without a preceding antepartum HDP admission were also identified. Risk for stillbirth, abruption, or both was compared between these two groups.
Results An estimated 382,621 deliveries with an HDP diagnosis were identified of which 14,857 (3.9%) had a preceding antepartum admission for HDP. Stillbirth occurred in 7.8 per 1,000 delivery hospitalizations complicated by HDP with risk higher with a preceding HDP antepartum admission in both unadjusted (1.1 vs. 0.8%, risk ratios [RR] 1.46, 95% confidence interval [CI] 1.24–1.70) and adjusted (adjusted risk ratios [aRR] 1.24, 95% CI 1.06, 1.46) analyses. Abruption occurred in 19.6 per 1,000 delivery hospitalizations complicated by HDP with risk higher with a preceding HDP antepartum admission in both unadjusted (2.5 vs. 1.9%, RR 1.30, 95% CI 1.17–1.44) and adjusted (aRR 1.24, 95% CI 1.11, 1.37) analyses. Risk for combined abruption and stillbirth did not differ significantly.
Conclusion In this analysis, prior antenatal hospitalization was associated with increased risk for stillbirth among women with HDP.
Drug-Induced Thrombocytopenia: Mechanisms and Laboratory Diagnostics
Authors: Danese Elisa , Montagnana Martina , Favaloro Emmanuel J. , Lippi Giuseppe 
Published: September 2019

AbstractThrombocytopenia is a condition characterized by a decreased number of platelets in peripheral blood, which can be caused by a myriad of both congenital and acquired disorders. Drug-induced thrombocytopenia (DIT) deserves a special focus since its cumulative incidence can be as high as 10 cases per million population per year, with a prevalence of approximately 25% in critically ill patients. This condition is usually suspected following identification of an acute and severe decrease in platelet count, with values usually < 50 ×109/L, thus potentially exposing patients to an increased risk of developing spontaneous hemorrhages. Conversely, however, some drug-related thrombocytopenias are instead (and perhaps counterintuitively) associated with increased thrombosis risk. Although a vast number of drugs have been implicated in DIT, the underlying pathogenetic mechanisms are essentially bifold, encompassing reduced platelet production due to bone marrow suppression (thus insufficient maturation or inefficient expansion of megakaryocytes, impaired release of platelets, or accelerated platelet apoptosis) or accelerated clearance of platelets from the circulation. This second form of DIT can be sustained by nonimmune, immune-mediated, or autoimmune mechanisms. An early and accurate diagnosis of DIT, which is crucial for reversing an otherwise unfavorable clinical outcome, is essentially based on the complete blood cell count, blood smear analysis, and performance of specific functional or immunochemical tests aimed at demonstrating the presence of antiplatelet antibodies.
Surgery in Traumatic Injury and Perioperative Considerations
Authors: Curry Nicola , Brohi Karim 
Published: September 2019

AbstractA severely injured patient presents several unique challenges to an admitting trauma team. Not only must the extent of the patient's injuries, particularly those that are life-threatening, be determined within minutes of hospital arrival, but also the trauma team needs to be able to assess whether the patient is bleeding and/or has an attendant coagulopathy. Early management of trauma patients is dictated by the presence (or absence) of significant bleeding. Standard definitive surgical procedures can be conducted in hemodynamically stable patients, but those in hemorrhagic shock should be treated according to damage control resuscitation (DCR) principles. DCR is a practice that has evolved over the last two to three decades, combining limited surgical techniques, which provide early hemorrhage control, and balanced transfusion resuscitation strategies, which mitigate (and ideally) treat trauma-induced coagulopathy (TIC). This review describes the contemporary perioperative management of trauma patients who have significant bleeding and/or TIC and sets out the evidence around the current approach for hemostatic resuscitation in these patients.
Using Artificial Intelligence to Manage Thrombosis Research, Diagnosis, and Clinical Management
Authors: Mishra Aastha , Ashraf Mohammad Zahid 
Published: September 2019

AbstractThrombosis development in either arterial or venous system remains a major cause of death and disability worldwide. This poorly controlled in vivo clotting could result in many severe complications including myocardial infarction, venous thromboembolism, stroke, and cerebral venous thrombosis, to name a few. These conditions are collectively known as thromboembolic disorders (TEDs). Appropriate understanding of TEDs is challenging, as they are multifactorial and involve several and often different risk factors. Hence, it requires a collective effort and data from numerous research studies to fully comprehend molecular mechanisms for prediction, prevention, treatment, and overall management of these conditions. To accomplish this arduous feat, a comprehensive approach is required that can compile thousands of available experimental data and transform these into more applicable and purposeful findings. Thus, large datasets could be utilized to generate models that could be predictive of how an individual would respond when subjected to any kind of additional risk factors or surgery, hospitalization, etc., or in the presence of some susceptible genetic variations. Artificial intelligence-based methods harness the capabilities of computer software to imitate human behaviors such as language translation, visual perception, and, most importantly, decision making. These emerging tools, if appropriately explored, might assist in processing of large data and tackle the complexities of identifying novel or interesting pathways that could otherwise be hidden due to their enormity. This narrative review attempts to compile the applications of various subfields of artificial intelligence and machine learning in the context of thrombosis research to date. It further reflects on the potential of artificial intelligence in transforming enormous research data into translational application in the form of predictive computational models.
The Erosive Potential of Some Flavoured Waters
Authors: Rees Jeremy , Loyn Theresa , Hunter Lindsay , Sadaghiani Leili , Gilmour Alan 
Published: September 2019

ABSTRACTObjectives: To assess the erosive potential of a number of readily available flavoured waters in the laboratory.Methods: The erosive potential was assessed by measuring the pH, neutralisable acidity and ability to erode enamel. These were compared to an orange juice positive control.Results: The pH of the flavoured waters ranged from 2.64-3.24 with their neutralisable acidity ranging from 4.16-16.30 mls of 0.1M NaOH. The amount of enamel removed following 1-hour immersion in the drinks ranged from 1.18-6.86 microns. In comparison, the orange juice control had a pH of 3.68, a neutralisable acidity of 19.68 mls of 0.1 M NaOH and removed 3.24 microns of enamel.Results: The pH of the flavoured waters ranged from 2.64-3.24 with their neutralisable acidity ranging from 4.16-16.30 mls of 0.1M NaOH. The amount of enamel removed following 1-hour immersion in the drinks ranged from 1.18-6.86 microns. In comparison, the orange juice control had a pH of 3.68, a neutralisable acidity of 19.68 mls of 0.1 M NaOH and removed 3.24 microns of enamel.
Fluoride Levels of Human Plasma and Breast Milk
Authors: Şener Yağmur , Tosun Gül , Kahvecioğlu Firdevs , Gökalp Alparslan , Koç Hasan 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to determine the fluoride levels in breast milk and plasma of lactating mothers who regularly consumed drinking water with low levels of fluoride.Methods: One hundred twenty five healthy mothers aged between 20-30 years old who had given birth within 5-7 days were included in the study. Besides being otherwise healthy, the primary selection criteria stipulated the absence of fluoride supplement consumption one month before delivery. Approximately 5 ml breast milk and 5 ml blood samples were obtained from each participating mother at a hospital setting, where the mothers were scheduled for a regular hospital diet. The blood samples were centrifuged in fluoride-free heparinized polyethylene tubes and stored at -18oC until measurements were made. Breast milk samples were directly refrigerated as with blood samples until measurements. The fluoride concentrations of milk and blood samples were assessed using an ion-selective fluoride electrode combined with an ion analyzer.Results: The fluoride levels of the plasma and breast milk samples were measured as 0.017±0.011 ppm and 0.006±0.002 ppm, respectively. The fluoride concentration of plasma was significantly higher than that of breast milk (P<.01). Correlation analysis revealed a significant relation between the groups (P<.01).Conclusion: A limited level of fluoride transmission from plasma to breast milk was detected. Nevertheless, a significant correlation between the fluoride concentrations of breast milk and plasma was evident. (Eur J Dent 2007;1:21-24)