bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis
Authors: Esparza‐Villalpando Vicente , Ortiz‐Barroso Gladys , Masuoka‐Ito David 
Published: November 2024

AbstractThe primary objective of the present review was to report the safety profile of oral ketorolac in adults using the systematic review and meta‐analysis methodology based on clinical trials. The present study is a PRISMA‐based systematic review and risk ratio (RR) meta‐analysis of the adverse events reported in clinical trials that used oral ketorolac; the review includes 50 clinical trials. The RR for the comparison of a single intake of oral ketorolac versus placebo, including all types of adverse events, was RR = 2.59, IC95% (1.5102; 4.4360) with p = 0.02, the RR for the comparison of a multiple intakes of oral ketorolac versus placebo for all types of adverse events was RR = 1.39, IC95% (0.95; 2.05) with p = 0.093, the RR for the comparison of a single intake of oral ketorolac versus active drugs for all types of adverse events was RR = 0.61, IC95% (0.49; 0.77) with p < 0.0001, the RR for the comparison of multiple intakes of oral ketorolac versus active drugs for all types of adverse events was RR = 0.78, IC95%(0.65; 0.93) with p = 0.006. Multiple intakes of 5, 10, or 20 mg of oral ketorolac, in treatment over 1–10 days, do not increase the risk of adverse events compared to placebo and show a tendency to reduce the risk of adverse events compared to active drugs. When a single intake of ketorolac (5, 10, 20, or 30 mg) is compared to a placebo, the risk increases only for trivial and mild adverse events.
Exploring key safety terminology through simulation: Definitions and practical insights
Authors: Badrnoebashar Helaleh , Klose Anselm , Lorenz Julius , Urbas Leon 
Published: November 2024

AbstractDesigning the process control of a system is a complex task that often involves different people. A uniform understanding of the terminology is necessary for the successful, resource‐saving implementation of the design. Therefore, this research aims at the definition and clarification of the key safety‐related concepts, including robustness, flexibility, sensitivity, fault tolerance, resilience, and nonfragile control. We first examine the definitions in academic literature and then analyze their differences. We utilize process engineering simulation examples to provide an in‐depth understanding of these distinctions. The significance of identifying and understanding the differences between these terms stems from their capacity to facilitate professional communication. Moreover, it makes it easier to deal with potential problems that might arise in real‐world scenarios.
Bayesian reliability acceptance sampling plan with optional warranty under hybrid censoring
Authors: Das Rathin , Pradhan Biswabrata 
Published: November 2024

AbstractThis work considers the design of a Bayesian reliability acceptance sampling plan (RASP) under a hybrid censored life test for the products sold under an optional warranty. The consumer and manufacturer agree on a common lifetime distribution of the product. However, they differ in the assessment of the prior distributions because of the adversarial nature of the consumer and manufacturer. The consumer takes a decision based on his/her utility and prior belief without a warranty offer by the manufacturer. If the decision is rejection, the manufacturer provides warranty offer to the consumer. If the consumer rejects the lot with a warranty, the manufacturer conducts a life test under the hybrid censoring scheme (HCS) and provides lifetime information to the consumer. The consumer updates his/her belief based on lifetime information provided by the manufacturer. The consumer then takes a decision of acceptance or rejection of the lot based on updated beliefs. The task of the manufacturer is to determine the optimal life testing plan.
Multi‐Objective Safety‐Enhanced Path Planning for the Anterior Part of a Flexible Ureteroscope in Robot‐Assisted Surgery
Authors: Zhang Chongan , Fu Zuoming , Liu Xiaoyue , Ding Guoqing , Qin Liping , Wang Peng , Zhang Hong , Ye Xuesong 
Published: November 2024

ABSTRACTBackgroundIn robot‐assisted flexible ureteroscopy, planning a safety‐enhanced path facilitates ureteroscope reaching the target safely and quickly. However, current methods rarely consider the safety impact caused by body motion of the anterior part, such as impingement on the lumen wall and sweeping motion risk, or the method can only be used in collision‐free situations.MethodsThe kinematic model of the anterior part under C‐shaped and S‐shaped collision bending is first analysed. Considering the newly defined impingement cost and sweeping area, the differential evolution algorithm is adopted to optimise the path in the configuration space. Experiments were performed to verify the effectiveness of the method.ResultsCompared with the competing algorithm, the proposed algorithm reduced impingement cost and sweeping area by an average of 31.0% and 8.64%. Force measurement experiments verified the rationality of the impingement cost expression.ConclusionThe experimental results proved the feasibility of the proposed path planning algorithm.
Industry peers stock liquidity and M&A
Authors: Dunham Lee M. , Obonyo Tirimba 
Published: November 2024

AbstractThis study examines the impact of mergers and acquisitions on the liquidity of shares of industry peers of the target firm. The results document, on average, an improvement in the liquidity of industry peer firms' shares: bid‐ask spreads of industry peers decline, the Amihud illiquidity measure declines, and their trading volumes increase around the merger announcement relative to a control sample. Industry peers of the target firm experience significant cumulative abnormal returns (CARs) that are increasing with the improvement in liquidity of the firms' shares. Our findings are consistent with the notion that the publicity and attention around the announcement of an acquisition involving a close industry peer results in benefits arising from increased liquidity of shares and offers a possible explanation for the positive CARs experienced by industry peers of the target firm around merger announcements.
Fluorescent “Switch‐off” Sensor for the Detection of Uric acid Using Europium‐2,6 Pyridine Dicarboxylic Acid Lanthanide Complex
Authors: Abraham Merin K. , Rajesh Amritha M. , Madanan Anju S. , Varghese Susan , Shkhair Ali Ibrahim , Indongo Geneva , Rajeevan Greeshma , K Arathy B. , George Sony 
Published: November 2024

AbstractIn this study, we have developed a europium‐DPA lanthanide complex for the sensitive detection of uric acid. Since, uric acid plays a major role as a biomarker for kidney related diseases and metabolic diseases. Its detection is of high clinical significance. Our probe exhibits a bright red fluorescence with an emission at 613 nm, which is subsequently quenched by the addition of uric acid in a linear range of 0–16.39 µM with a low LOD of 7.54 µM. The probe shows good selectivity and sensitivity towards the detection of uric acid in the presence of coexisting biomarkers and ions present in body fluid. The clinical significance is evaluated in biological samples such as human serum and urine with satisfactory recovery percentage in the range of 86%–104%, respectively. Moreover, the practical applicability is studied in a paper strip model.
Incredible Indolinedione Derivatives Nucleus in the Development of Anti‐Diabetic Drugs: Exploring the Mechanistic Studies, Design, and Structure‐Activity Relationship
Authors: Khanna Aanchal , Jyoti  , Kumar Nitish , Singh Karanvir , Sharma Anchal , Rana Rupali , Kaur Rubaldeep , Singh Jatindervir , Gulati Harmandeep Kaur , Bedi Preet Mohinder Singh 
Published: November 2024

AbstractDiabetes mellitus, a prevalent metabolic disorder, necessitates continuous exploration for innovative therapeutic agents. Indolinedione has garnered attention for its potential as an antidiabetic scaffold for its structurally diverse nucleus. The search for novel and effective antidiabetic agents has led to the exploration of natural compounds and synthetic derivatives. The review commences with an in‐depth exploration of the biochemical underpinnings of diabetes mellitus, emphasizing rational design strategies employed for modifying the indolinedione nucleus, encompassing various synthetic methodologies aimed at enhancing its pharmacological properties and docking studies. The multifaceted pharmacological properties and diverse synthetic derivatives of indolinedione offer a fertile ground for further exploration in preclinical and clinical studies. As research in this field progresses, indolinedione may emerge as a valuable addition to the arsenal of antidiabetic therapeutics, providing new avenues for the effective management of diabetes mellitus.
Urban Environmental Threat Moderates the Relationship Between Depression and Insulin Resistance Among Latinxs With Type 2 Diabetes
Authors: Matlock Kevin A. , Albright‐Pierce Maggie R. , Bermúdez‐Millán Angela , Pérez‐Escamilla Rafael , Segura‐Pérez Sofia , Wagner Julie 
Published: November 2024

ABSTRACTAs the largest minoritised ethnic group in the United States, Latinxs face a greater risk for type 2 diabetes and depression. The aim of the present study was to explore whether the relationship between depressive symptoms and insulin resistance among Latinxs with type 2 diabetes was moderated by toxic stressors arising from urban environmental threat (i.e., uncomfortable or unsafe aspects of city life). A community sample of Latinx adults with type 2 diabetes (n = 121) was recruited from Hartford, Connecticut. Participants self‐reported depressive symptoms and exposure to urban environmental threat using items from the Patient Health Questionnaire and Urban Hassles Index, respectively. Insulin and glucose levels assessed via fasting blood draw were used to calculate insulin resistance using the HOMA‐IR formula. After controlling for demographic, financial and health‐related factors, results from a regression analysis revealed a significant interaction between depressive symptoms and urban environmental threat; more severe symptoms of depression predicted greater insulin resistance, but only amongst those with frequent exposure to urban environmental threats. Findings from the current study suggest that improving urban living conditions may offer an alternate avenue for attenuating the deleterious impacts of depression on type 2 diabetes progression in Latinxs.
Confined Magnetization at the Sublattice‐Matched Ruthenium Oxide Heterointerface
Authors: Fan Yiyan , Zhang Qinghua , Lin Ting , Bai He , Huo Chuanrui , Jin Qiao , Deng Tielong , Choi Songhee , Chen Shengru , Hong Haitao , Cui Ting , Wang Qianying , Rong Dongke , Liu Chen , Ge Chen , Zhu Tao , Gu Lin , Jin Kuijuan , Chen Jun , Guo Er‐Jia 
Published: November 2024

AbstractCreating a heterostructure by combining two magnetically and structurally distinct ruthenium oxides is a crucial approach for investigating their emergent magnetic states and interactions. Previously, research has predominantly concentrated on the intrinsic properties of the ferromagnet SrRuO3 and recently discovered altermagnet RuO2 solely. Here, the study engineers an ultrasharp sublattice‐matched heterointerface using pseudo‐cubic SrRuO3 and rutile RuO2, conducting an in‐depth analysis of their spin interactions. Structurally, to accommodate the lattice symmetry mismatch, the inverted RuO2 layer undergoes an in‐plane rotation of 18 degrees during epitaxial growth on SrRuO3 layer, resulting in an interesting and rotational interface with perfect crystallinity and negligible chemical intermixing. Performance‐wise, the interfacial layer of 6 nm in RuO2 adjacent to SrRuO3 exhibits a nonzero magnetic moment, contributing to an enhanced anomalous Hall effect (AHE) at low temperatures. Furthermore, the observations indicate that in contrast to SrRuO3 single layers, the AHE of [(RuO2)15/(SrRuO3)n] heterostructures show nonlinear behavior and reaches its maximum when the SrRuO3 thickness reaches tens of nm. These results suggest that the interfacial magnetic interaction surpasses that of all‐perovskite oxides (≈5‐unit cells). This study underscores the significance and potential applications of magnetic interactions based on the crystallographic asymmetric interfaces in the design of spintronic devices.
Nanostructure and Photovoltaic Potential of Plasmonic Nanofibrous Active Layers
Authors: Schofield Ryan M. , Maciejewska Barbara M. , Elmestekawy Karim A. , Woolley Jack M. , Tebbutt George. T. , Danaie Mohsen , Allen Christopher S. , Herz Laura M. , Assender Hazel E. , Grobert Nicole 
Published: November 2024

AbstractNanofibrous active layers offer hierarchical control over molecular structure, and the size and distribution of electron donor:acceptor domains, beyond conventional organic photovoltaic architectures. This structure is created by forming donor pathways via electrospinning nanofibers of semiconducting polymer, then infiltrating with an electron acceptor. Electrospinning induces chain and crystallite alignment, resulting in enhanced light‐harvesting and charge transport. Here, the charge transport capabilities are predicted, and charge separation and dynamics are evaluated in these active layers, to assess their photovoltaic potential. Through X‐ray and electron diffraction, the fiber nanostructure is elucidated, with uniaxial elongation of the electrospinning jet aligning the polymer backbones within crystallites orthogonal to the fiber axis, and amorphous chains parallel. It is revealed that this structure forms when anisotropic crystallites, pre‐assembled in solution, become oriented along the fiber– a configuration with high charge transport potential. Competitive dissociation of excitons formed in the photoactive nanofibers is recorded, with 95%+ photoluminescence quenching upon electron acceptor introduction. Transient absorption studies reveal that silver nanoparticle addition to the fibers improves charge generation and/or lifetimes. 1 ns post‐excitation, the plasmonic architecture contains 45% more polarons, per exciton formed, than the bulk heterojunction. Therefore, enhanced exciton populations may be successfully translated into additional charge carriers.
Oxygen Vacancy Engineering of TiNb2O7 Modified PE Separator Toward Dendrite‐Free Lithium Metal Battery
Authors: Tang Wenhao , Deng Yirui , Xing Zhiwei , Zhang Xin , Zhou Taotao , Hou Lianlong , Zhao Dalei , Liu Ruiping 
Published: November 2024

AbstractLithium metal battery with high specific energy and high safety is crucial for the next‐generation energy storage technologies. However, the poor thermal stability, lower mechanical performance, and poor electrochemical performance of the commercially available polyethylene (PE) separator hinders the development of high‐specific lithium metal batteries. Herein, a functional PE separator is prepared by innovative coating the TiNb2O7 microspheres with oxygen vacancies on the surface of PE (denoted as TNO−x‐PE). The porosity, contact angle, electrolyte uptake rate, thermal shrinkage rate, mechanical properties, conductivity as well as lithium ions transference number of the TNO−x modified PE separator are all improved. The favorable TNO−x is beneficial for facilitating fast Li+ migration and impeding anions transfer, guiding the uniform distribution of lithium‐ion flux. Consequently, the lithium symmetric cells with TNO−x‐PE separator can be stably cycled more than 1600 h at 1 mA cm−2, and the initial capacity of the LFP/Li cells with TNO−x‐PE separator is as high as 139.8 mAh g−1, and after 500 cycles, the capacity retention rate is still 99.5%. This work may provide a new idea to construct a multi‐functional separator with high safety and superior electrochemical performance and promote the development of LMBs.
Recent Advances in Selenium‐Mediated Redox Functional Group Interconversions
Authors: Capperucci Antonella , Tanini Damiano 
Published: November 2024

AbstractThe conversion of a functional group into another represents the core of organic synthesis. Within the arena of functional group interconversions, oxidative and reductive transformations occupy a privileged position and the development of new sustainable, selective, and general methodologies continue to attract significant interest. Owing to the versatility of their chemistry, selenium compounds offer significant opportunities to achieve both oxidation and reduction of a wide range of functional groups. Additionally, the possibility to generate in situ the active oxidant or reducing selenium species from suitable inert precursors enables the development of catalytic processes. In this review, recent advances in selenium‐mediated oxidative and reductive functional group interconversions, with particular emphasis on cutting‐edge researches bringing about new insights into the comprehension of their mechanistic aspects, will be discussed.
Assessment of disease impact through health‐related quality of life measurement in primary progressive aphasia
Authors: Hopkins Thomas , Kwon Eunbi , Lapins Allison , Gill Nathan , Roberts Angela , Rogalski Emily 
Published: November 2024

AbstractINTRODUCTIONMeasurements of health‐related quality of life (HRQoL) are important for capturing disease impact beyond physical health and relative to other diseases but have rarely been assessed in primary progressive aphasia (PPA).METHODSHRQoL was characterized overall, by sex and subtype in PPA (n = 118) using the Health Utilities Index‐2/3 (HUI2/3). Multiple linear regression assessed associations between HRQoL and language severity.RESULTSMulti‐attribute HUI2/3 summary scores indicated moderate to severe impairment. Scores did not differ by sex and were more severe for semantic than non‐semantic PPA. Language severity scores showed significant associations with HUI multi‐attribute scores and select single‐attribute measures (hearing, sensation, cognition, and speech) with less language impairment associated with better functional capacity related to HRQoL.DISCUSSIONThis study identified poor HRQoL in a relatively large PPA cohort. HRQoL measures aid in determining patient perspective, policy decision making, and resource allocation. Results may be used to advocate for PPA support.Highlights
Primary progressive aphasia (PPA) negatively impacts health‐related quality of life.
Health utilities index scores are associated with Western Aphasia Battery performance in PPA.
Severity of language impairment in PPA is associated with poorer quality of life.
Good functional outcome following open‐chest cardiopulmonary resuscitation in a dog with pleural space disease
Authors: Escande Etienne , Lejoncq Myriam , Graziano Nicolas , Giansetto Thomas , Kennedy Christopher R. 
Published: November 2024

AbstractA 5‐year‐old neutered male German Hound was referred for management of pyothorax. After needle thoracocentesis and intubation for a computed tomography scan, a paraesophageal abscess and lung consolidation were identified. The dog experienced cardiopulmonary arrest (CPA), likely from tension pneumothorax. Sinus bradycardia led to asystole within 60 s. Open‐chest cardiopulmonary resuscitation (OCCPR) was immediately performed through a right‐sided thoracotomy, with direct cardiac compressions, manual ventilation and administration of atropine and adrenaline per RECOVER guidelines. Spontaneous circulation returned within 6 min. The paraesophageal abscess was addressed surgically through a sternotomy, with lavage of the thoracic cavity, chest tube placement and closure of both thoracic entry points. Postoperative care included oxygen therapies, transfusions and fluids. The dog was discharged 6 days post‐CPA and remained healthy 6 months later. This case indicates that OCCPR can be effective for CPA in dogs with pleural space disease when performed via a right‐sided thoracotomy, in conjunction with intensive post‐arrest care.
Interactional Aerodynamics Analysis of a Multirotor Energy Kite
Authors: Mehr Judd , Alvarez Eduardo J. , Ning Andrew 
Published: November 2024

ABSTRACTAirborne wind energy (AWE) technology aspires to provide increased options for wind energy harvesting at a lower cost than conventional turbines. As AWE technology is still in its infancy, there is relatively little published information concerning its aerodynamic details. In this study, we apply the FLOWUnsteady suite of aerodynamic analysis tools—including a vortex particle method for wakes and actuator line methods for rotors and wings—to the analysis of a fixed‐wing, on‐board generation, wind harvesting aircraft (or windcraft for short). Specifically, we explore variations in the rotation directions and vertical and horizontal (front to back) spacing of the rotors to understand the complex interactional aerodynamics of a multirotor windcraft design. Our results indicate that for the configurations presented herein, the rotor‐on‐rotor and wing‐on‐rotor interactions induce maximum total variations on cumulative rotor performance of less than 3% relative to baseline, with most configurations varying from baseline by 2% or less. In addition, rotor‐on‐wing interactions cause decreases in wing lift coefficient of up to roughly 7% (for the configurations simulated) relative to the isolated wing. Furthermore, through selecting specific rotor rotation directions, it is possible to prescribe a portion of the shape of the wing lift distribution. Further exploration, perhaps with the assistance of optimization techniques, may yield greater insights into this uncharted space of windcraft interactional aerodynamics.
Provision of inguinal hernia surgery in first‐referral hospitals across low‐ and middle‐income countries: Secondary analysis of an international cohort study
Authors: Picciochi Maria , Alexander Philip Vareed , Anyomih T. , Boumas N. , Crawford R. , Enoch Gyamfi F. , Hopane N. , Isiagi M. , Kamarajah S. K. , Ledda V. , Matei A. , Mulliez A. , Nepogodiev D. , Roy N. , Okereke C. E. , Tubasiime R. , Steinruecke M. , Bhangu A. ,   NIHR Global Health Research Unit on Global Surgery
Published: November 2024

AbstractIntroductionSurgical care in first‐referral hospitals (FRHs) in low‐ and middle‐income countries (LMICs) is poorly characterized. Inguinal hernia repair can act as a good tracer condition. This study aimed to evaluate the variation in hernia repair across different hospital types in LMICs.MethodsWe conducted a secondary analysis of an international prospective cohort study of hernia surgery. Data was collected from consecutive patients undergoing primary inguinal hernia repair between 30 January and May 21, 2023. We characterized patients from LMICs, comparing first‐referral, secondary, and tertiary hospitals. Emergency surgery, financing methods, mesh use, and complications were defined as key performance measures relevant for FRHs. A multilevel logistic regression model was used to test associations between complications and hospital type.ResultsThis analysis included 8155 patients undergoing hernia repair across 328 hospitals in 55 LMICs. Most patients were male (89.8%, 7324/8155), of working age (mean age 41.6, SD 25.3). Emergency surgery rates were similar across first‐referral, secondary and tertiary hospitals (11.1%, 10.9%, and 9.6%, respectively). Patients in FRHs were most likely to experience out‐of‐pocket payments (31.4%, 9.4%, and 17.4%). They also had lower rates of mesh use (71.9%, 82.1%, and 84.1%) and higher postoperative complication rates (19.1%, 12.5%, and 14.0%), although complications were similar after adjustment (adjusted odds ratio 1.71, 95% CI 0.83–3.54, p = 0.148).DiscussionThis sample of FRHs is capable of delivering simple elective surgery, reducing the burden on subsequent referral hospitals. To scale these surgical pathways, FRHs need support to increase the use of mesh and ensure cost protection for patients.