bluuebunny/crossref_metadata_2025_split huggingface dataset:
Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial
Authors: del Campo Josep M. , Matulonis Ursula A. , Malander Susanne , Provencher Diane , Mahner Sven , Follana Philippe , Waters Justin , Berek Jonathan S. , Woie Kathrine , Oza Amit M. , Canzler Ulrich , Gil-Martin Marta , Lesoin Anne , Monk Bradley J. , Lund Bente , Gilbert Lucy , Wenham Robert M. , Benigno Benedict , Arora Sujata , Hazard Sebastien J. , Mirza Mansoor R. 
Published: June 2019

PURPOSE In the ENGOT-OV16/NOVA trial (ClinicalTrials.gov identifier: NCT01847274 ), maintenance therapy with niraparib, a poly(ADP-ribose) polymerase inhibitor, prolonged progression-free survival in patients with platinum-sensitive, recurrent ovarian cancer who had a response to their last platinum-based chemotherapy. The objective of the study was to assess the clinical benefit and patient-reported outcomes in patients who had a partial response (PR) and complete response (CR) to their last platinum-based therapy. PATIENTS AND METHODS A total of 553 patients were enrolled in the trial. Of 203 patients with a germline BRCA mutation (g BRCAmut), 99 had a PR and 104 had a CR to their last platinum-based therapy; of 350 patients without a confirmed g BRCAmut (non–g BRCAmut), 173 had a PR and 177 had a CR. Post hoc analyses were carried out to evaluate safety and the risk of progression in these patients according to g BRCAmut status and response to their last platinum-based therapy. Ovarian cancer–specific symptoms and quality of life were assessed using the Functional Assessment of Cancer Therapy–Ovarian Symptom Index. RESULTS Progression-free survival was improved in patients treated with niraparib compared with placebo in both the g BRCAmut cohort (PR: hazard ratio [HR], 0.24; 95% CI, 0.131 to 0.441; P < .0001; CR: HR, 0.30; 95% CI, 0.160 to 0.546; P < .0001) and the non–g BRCAmut cohort (PR: HR, 0.35; 95% CI, 0.230 to 0.532; P < .0001; CR: HR, 0.58; 95% CI, 0.383 to 0.868; P = .0082). The incidence of any-grade and grade 3 or greater adverse events was manageable. No meaningful differences were observed between niraparib and placebo in PR and CR subgroups with respect to patient-reported outcomes. CONCLUSION Patients achieved clinical benefit from maintenance treatment with niraparib regardless of response to the last platinum-based therapy.
Percepção do estresse e estressores de enfermeiros de um hospital universitário
Authors: Silva Jéssica Martins da , Malagris Lucia Emmanoel Novaes 
Published: June 2019

Este estudo avaliou a percepção de estresse e estressores de enfermeiros de um hospital universitário e coletou sugestões de ações para amenizar o estresse. O estudo, descritivo, transversal, qualitativo e quantitativo foi realizado com 70 enfermeiros de diversas unidades de um hospital. Utilizou-se a Escala de Estresse de Bianchi e uma pergunta aberta. Os dados quantitativos foram analisados pelo programa SPSS e foram feitas análises descritivas e inferenciais. Para os dados qualitativos, utilizou-se a técnica de análise de conteúdo de Bardin. Resultados indicaram que a maior parte (67%) dos sujeitos apresentou nível médio de estresse. O domínio B (atividades relacionadas ao funcionamento adequado da unidade) teve a média de escore de estresse mais alta (5,2) em todas as unidades estudadas. A média de estresse dos enfermeiros que exercem função de chefia foi significantemente maior do que a média dos que não exercem (p=0,002). A área temática "Melhores condições para o trabalho" foi a mais citada como sugestão para amenizar o estresse. Os dados obtidos indicaram que a situação atual de precarização do hospital está relacionada com o estresse dos enfermeiros. Considera-se que o estudo permitiu ampla compreensão sobre o estresse e estressores em enfermeiros do hospital e subsídios para estudos posteriores.
Diagnosis of Cancer Using Hybrid Clustering and Convolution Neural Network from Breast Thermal Image
Authors: Lakshminarayanan Aarthy Seshadri , Radhakrishnan Sujatha , Pandiasankar Gopinath Masila , Ramu Swarnapriya 
Published: June 2019

Abstract
Breast cancer is a tumor caused by the excessive growth of cells in the breast tissue or near the region of the breast. Breast cancer is most commonly found among women, and it starts developing when the cell tissues from lump of the breast become abnormal or when there is a calcium deposit in the breast. These affected cells form a large lump that consequently becomes a tumor. Digital infrared images are obtained based on the metabolism of the breast and vascular circulation of the blood flow in and around the breast region, which has more visibility than the normal breast region. In this article, we diagnose breast cancer by processing a thermal image that is acquired from thermal cameras. By analyzing the information, we can implement image processing steps to predict quantitative and qualitative information. In this work, we propose a hybrid clustering algorithm with distance measurements. The clustering step includes adaptive fuzzy k-means clustering with Chebyshev distance with improved classifiers, which include neural networks. The article discusses the experimental results along with the comparison using various metrics, such as accuracy, time, and error rates.
FORMAS DE ORGANIZAÇÃO DA DEMANDA DE FIRMAS DE TI NO MERCADO DE TRABALHO
Authors: Rodrigues Azambuja Lucas 
Published: June 2019

Este artigo propõe compreender o comportamento das firmas no mercado de trabalho, através da análise de redes sociotécnicas. Evidenciamos que algumas características dessas redes dependem de aspectos organizacionais das empresas que, por sua vez, estão relacionados ao contexto mais amplo da chamada nova economia. Foi analisada a inter-relação entre redes sociotécnicas e características organizacionais na nova economia, com o objetivo de compreender o processo de construção social sobre o qual assenta a ida das empresas como demandantes no mercado de trabalho. Procedeu-se à realização de quatro estudos de casos em empresas de tecnologias da informação, situadas em Porto Alegre (RS) e Região Metropolitana. Com base na análise dos dados levantados através de entrevistas, observação e coleta de documentos, constatou-se que quanto mais uma firma apresenta características organizacionais típicas da nova economia, maior é o número de agentes integrados em sua rede sociotécnica e mais intensas serão as relações entre eles. Palavras-chave: Sociologia Econômica; Sociologia dos Mercados; Sociologia das Organizações
Programa de Integração e Inclusão étnico-racial e cotas para negros na Universidade do Estado de Mato Grosso: uma breve análise sobre a primeira década (2005-2015)
Authors: Teixeira Laudiceia Fagundes , Vieira Paulo Alberto Dos Santos 
Published: June 2019

Em setembro de 2015, em reunião ordinária, o Conselho de Ensino, Pesquisa e Extensão da Universidade do Estado de Mato Grosso prorrogou por mais dez anos o Programa de Integração e Inclusão Étnico-racial (Piier/Unemat), que se traduz nas cotas para negros desta universidade. Nesta reunião chamou a atenção algumas situações, dentre as quais merecem destaque: a. posição da maioria do pleno, amplamente favorável à prorrogação; b mudança de posição em relação às cotas, na medida em que alguns atores que eram contrários em 2005 discursaram em prol da continuidade do programa; e c. absoluta ausência de qualquer tipo de dado e/ou informação oficial referente ao Programa. Neste artigo, pretende-se desenvolver argumentação que demonstre que a aprovação da prorrogação do Piier/Unemat não significou que as políticas de ação afirmativa, com recorte étnico-racial, sejam apoiadas. Buscar-se-á demonstrar que, paradoxalmente, a prorrogação pode ter por base a consolidação de práticas acadêmicas que tendem a dificultar, e no limite impedir, a presença negra no interior da universidade. Para tanto o texto possui uma introdução, uma sessão acerca do conceito e histórico, outra relativa à Unemat e observações à guisa de conclusões.Palavras-Chave: Cotas para negros; Unemat; Mato Grosso.
Genomic Selection with Allele Dosage in Panicum maximum Jacq.
Authors: de C. Lara Letícia A , Santos Mateus F , Jank Liana , Chiari Lucimara , Vilela Mariane de M , Amadeu Rodrigo R , dos Santos Jhonathan P R , Pereira Guilherme da S , Zeng Zhao-Bang , Garcia Antonio Augusto F 
Published: June 2019

Abstract
Genomic selection is an efficient approach to get shorter breeding cycles in recurrent selection programs and greater genetic gains with selection of superior individuals. Despite advances in genotyping techniques, genetic studies for polyploid species have been limited to a rough approximation of studies in diploid species. The major challenge is to distinguish the different types of heterozygotes present in polyploid populations. In this work, we evaluated different genomic prediction models applied to a recurrent selection population of 530 genotypes of Panicum maximum, an autotetraploid forage grass. We also investigated the effect of the allele dosage in the prediction, i.e., considering tetraploid (GS-TD) or diploid (GS-DD) allele dosage. A longitudinal linear mixed model was fitted for each one of the six phenotypic traits, considering different covariance matrices for genetic and residual effects. A total of 41,424 genotyping-by-sequencing markers were obtained using 96-plex and Pst1 restriction enzyme, and quantitative genotype calling was performed. Six predictive models were generalized to tetraploid species and predictive ability was estimated by a replicated fivefold cross-validation process. GS-TD and GS-DD models were performed considering 1,223 informative markers. Overall, GS-TD data yielded higher predictive abilities than with GS-DD data. However, different predictive models had similar predictive ability performance. In this work, we provide bioinformatic and modeling guidelines to consider tetraploid dosage and observed that genomic selection may lead to additional gains in recurrent selection program of P. maximum.
Instability formation in epitaxial SiGe lines under hydrogen annealing
Authors: Seiss Birgit , Brémond Georges , Dutartre Didier 
Published: June 2019

ABSTRACTThe influence of film thickness and line width on the morphology of epitaxial SiGe was studied after an annealing step. The morphology of 5 nm and 19 nm thick SiGe was characterized in 60-490 nm wide lines which were oriented along <100> on Si (001) substrates. We have shown that the annealed SiGe morphology changed significantly as a function of line width and film thickness. Wide lines of 19 nm thick SiGe showed ridge formation; as the line width was decreased the morphology stabilized and then became unstable with the formation of bulges. The morphology of 5 nm thick SiGe consisted of ridges in wide lines, changed to faceted islands in narrower lines and was stable in the narrowest lines.
In situ X-ray Studies of (La,Sr)MnO3_δ, (La,Sr)CoO3_δ, and La0.6Sr0.4Co0.2Fe0.8O3-δ Thin Film SOFC Cathodes Grown by Pulse Laser Deposition
Authors: Chang Kee-Chul , Ingram Brian , Salvador Paul , Yildiz Bilge , You Hoydoo 
Published: June 2019

ABSTRACTWe will briefly review in situ synchrotron x-ray investigation of model thin film cathode systems for solid oxide fuel cells. The film cathodes examined in this study are (La,Sr)MnO3_δ (LSM), (La,Sr)CoO3_δ (LSC), and La0.6Sr0.4Co0.2Fe0.8O3-δ (LSCF) thin films epitaxially grown on YSZ single crystal substrates by the pulse laser deposition technique. We find in all cases that Sr is enriched or segregated to the surface of the film cathodes. We concluded that the Sr enrichments or segregations are mainly the results of annealing because they do not depend on whether the cathodes are electrochemically biased or not during annealing. However, at least in the case of LSCF, we find that B-site Co segregates rather uniformly to the surface and the segregation responds sensitively and reversibly to the electrochemical bias.
Ab initio Simulation of 1D Pattern Formation of Adsorbates on the Ge(100)-2 × 1 Surface
Authors: Shong Bonggeun , Bent Stacey F. 
Published: June 2019

ABSTRACTIt is known that methanol and ethylene form distinct one-dimensional patterns along the dimer row on the Ge(100)-2 × 1 surface. A unified explanation for the pattern formation is attempted in this study through theoretical methods. Kinetic parameters of the precursor-mediated adsorption of the two molecules are calculated using density functional theory methods. The potential energy surface along the reaction channel was found to vary according to nearest-neighbor occupation. Monte Carlo simulations were performed with calculated kinetic coefficients and assumptions of a one-dimensional lattice with nearest neighbor interactions. The simulation results effectively reproduce the coverage-dependent evolution of longer-range adsorption patterns.
Modeling and Fabrication of Quantum Dot Channel Field Effect Transistors Incorporating Quantum Dot Gate
Authors: Kondo Jun , Lingalugari Murali , Chan Pik-Yiu , Heller Evan , Jain Faquir 
Published: June 2019

ABSTRACTQuantum dot gate (QDG) field-effect transistors (FET) have shown three-state transfer characteristics. Quantum dot channel (QDC) field-effect transistors (FET) have exhibited fourstate ID-VG characteristics. This project aims at studying the effect of incorporating cladded quantum dot layers in the gate region of QDC-FET. Four-state characteristics are explained by carrier transport in narrow energy mini-bands which are manifested in a quantum dot superlattice (QDSL) channel. QDSL is formed by an array of cladded quantum dots (such as SiOx-Si and GeOx-Ge). Multi-state FETs are needed in multi-valued logic (MVL) that can reduce the number of gates and transistors in digital circuits. The fabricated device showed the four-state characteristic (OFF, ‘I1’, ‘I2’, ON).
Thermoelectric Properties of Some Cobalt Phosphide-Arsenide Compounds
Authors: Watcharapasorn Anucha , DeMattei Robert C. , Feigelson Robert S. , Caillat Thierry , Borshchevsky Alexander , Jeffrey Snyder G. , Fleurial Jean-Pierre 
Published: June 2019

ABSTRACTSamples of CoP3, CoAs3 and CoP1.5As1.5 have been synthesized and their thermoelectric properties measured. All three samples show semiconducting behavior. The Seebeck coefficients of CoP3 and CoAs3 are weakly dependent on temperature and are relatively small with maximum values of about 40 and 50 μV/K, respectively. The Seebeck coefficient of the solid solution gradually decreases with increasing temperature and the values are larger than those of CoP3 and CoAs3 in the temperature range investigated, with a maximum value of about 89 μV/K near room temperature. The thermal conductivity of CoP3 and CoAs3 are higher than that of CoSb3, as can be expected from the effect of anionic size on lattice vibration. A substantial reduction in thermal conductivity was observed for the solid solution compared to the constituent binary compounds due to additional phonon scattering from lattice disorder and other possible point defects such as vacancies. Other compositions in the CoP3-xAsx system have also been synthesized and their thermoelectric properties are currently being investigated to provide essential information about lattice thermal conductivity reduction by point defect scattering and to further develop strategies for optimizing the thermoelectric properties of skutterudite materials.
Bulk Synthesis of Completely and Partially Sn filled CoSb3 Using the Multilayer Repeat Method
Authors: Sellinschegg Heike , Johnson David C. , Kaeser Michael , Tritt Terry M. , Nolas George S. , Nelson E. 
Published: June 2019

ABSTRACTFilled skutterudite compounds possess very low thermal conductivities due to the scattering of a wide range of phonon modes caused by a loosely bound cation incorporated in a cavity of the structure. The inclusion of such a filler cation causes several synthetic difficulties since the desired compounds are thermodynamically unstable with respect to disproportionation. Modulated elemental reactants were used in this study to circumvent these difficulties. SnxCo4Sb12 samples with x=0.5 and nearly 1.0 were synthesized using this method. To prevent nucleation of unwanted binary compounds, the repeat unit made up of elemental layers was less than 20 angstroms 500mg of each sample were produced, allowing for the samples to be hot pressed into a pellet. Structural analysis as well as measurements of the physical properties are presented.
Thermal Conductiviy of type I and II Clathrate Compounds
Authors: Nolas G.S. , Cohn J.L. , Kaeser M. , Tritt T.M. 
Published: June 2019

ABSTRACTCompounds with clathrate-hydrate type crystal lattice structures are currently of interest in thermoelectric materials research. This is due to the fact that semiconducting compounds can be synthesized with varying doping levels while possessing low, even ‘glass-like’, thermal conductivity. Up to now most of the work has focused on type I Si and Ge clathrates. Sn-clathrates however are viewed as having the greatest potential for thermoelectric cooling applications due to the larger mass of Sn and the expected small band-gap, as compared to Si and Ge clathrates. Transport properties on type I Sn-clathrates has only recently been reported [1–3]. In this report we present ongoing experimental research on both type I and II clathrates with an emphasis on the thermal transport of these novel materials. We present thermal conductivity data Si-Ge and Ge-Sn alloys as well as on a type II Ge clathrate for the first time, and compare these data to that of other clathrate compounds.
Epitaxial Growth and Thermoelectric Properties of Bi2Te3 Based Low Dimensional Structures
Authors: Nurnus Joachim , Beyer Harald , Lambrecht Armin , Böttner Harald 
Published: June 2019

ABSTRACTBi2Te3 based low dimensional structures are interesting material systems to increase the thermoelectric figure of merit ZT by either the expected reduction of the thermal conductivity or by a possible power factor enhancement due to quantum confinement. Due to low lattice mismatch Bi2(Te1-xSex)3, PbSe1-xTex, as well as Pb1-xSrxTe, and BaF2 are suitable for Bi2Te3 based low dimensional structures. Especially due to their significantly enhanced band gap lead chalcogenide compounds like Pb1-xSrxTe (Pb0.87Sr0.13Te: 0.6 eV) are well-suited barrier materials in MQW structures. Alternatively the insulator BaF2 can be used for that purpose.Here we report mainly on results of different superlattice structures mentioned above grown by molecular beam epitaxy (MBE) on BaF2(111). The structural properties of these layers were investigated by X-ray diffractometry (XRD), scanning electron microscopy (SEM) and secondary ion mass spectroscopy (SIMS). Structural performance and thermoelectric properties of different Bi2Te3 based superlattices were reported and compared with regard to their superlattice parameters.
Enhancement Of Power Factor In A Thermoelectric Composite With A Periodic Microstructure
Authors: Fel Leonid G. , Strelniker Yakov M. , Bergman David J. 
Published: June 2019

ABSTRACTThe thermoelectric power factor has been calculated for a two-constituent composite medium, where one constituent is a “high quality thermoelectric” while the other constituent is a “benign metal”, with large electrical and thermal conductivities but poor thermoelectric properties. It was recently discovered that, in such a mixture, the power factor could be greatly enhanced by an appropriate choice of microstructure. Here we report on a study of three periodic microstructures with cubic point symmetry under rotations: simple cubic (SC), body centered cubic (BCC), and face centered cubic (FCC) arrays of identical spheres of the benign metal embedded in the high quality thermoelectric host. We show detailed results for these microstructures in the case where the benign metal constituent is Copper, while the high quality thermoelectric constituent is the thermoelectric alloy (Bi2Te3)0.2 (Sb2Te3)0.8.
Doping Studies of n-Type CsBi4Te6 Thermoelectric Materials
Authors: Lane Melissa A. , Ireland John R. , Brazis Paul W. , Kyratsi Theodora , Chung Duck-Young , Kanatzidis Mercouri G. , Kannewurf Carl R. 
Published: June 2019

ABSTRACTWe have previously reported the successful p-type doping of CsBi4Te6 which had a high figure of merit at temperatures below 300 K. In this study, several dopants were explored to make n-type CsBi4Te6. A program of measurements was performed to identify the optimum doping concentration for several series of dopants. The highest power factors occurred around 125 K for the 0.5% Sn doped CsBi4Te6 sample which had a power factor of 21.9 μW/cm•K2 and 1.0% Te doped CsBi4Te6 which had a power factor of 21.7 μW/cm•K2.
A Simple Description of Thick Avalanches at the Surface of a Granular Material
Authors: Aradian Achod , Raphaël Elie , de Gennes Pierre-Gilles 
Published: June 2019

ABSTRACTSome years ago, Bouchaud et al. introduced a phenomenological model to describe surface flows of granular materials [J. Phys. Fr. I 4, 1383 (1994)]. According to this model, one can distinguish between a static phase and a rolling phase that are able to exchange grains through an erosion/accretion mechanism. Later, Boutreux et al. [Phys. Rev. E 58, 4692 (1998)] proposed a modification of the exchange term in order to describe thicker flows where saturation effects are present. However, these two approaches assumed that the downhill convection velocity of the grains is constant inside the rolling phase, a hypothesis that is not verified experimentally. We have recently modified the above models by introducing a velocity profile in the flow, and analyzed the physical consequences of this modification in the simple situation of an avalanche in an open cell. We here emphasize the physical predictions of our model, and show, in particular, that the thickness of the avalanche depends strongly on the velocity profile.
Impulse acoustics based ejection of ferrofluid grains from a ferrofluid: the blueprint of a concept for a nozzle-free inkjet printer
Authors: Manciu Felicia S. , Manciu Marian , Sen Surajit 
Published: June 2019

ABSTRACTWe present numerical simulations to demonstrate that it may be possible to eject ferrofluid grains from a ferrofluid using non-linear acoustic impulses. The study considers a container with some dilute ferrofluid that is placed in a strong, vertical, homogeneous magnetic field. The field induces the formation of magnetic dipoles into vertical chains that approximately span the region between the base and the surface of the container. We use particle dynamical simulations to show that an impulse generated at the base of any chain, will typically travel as a weakly dispersive bundle of energy. When the impulse magnitudes are appropriate (typically ∼60 m/s or more) the ferrofluid grain nearest to the surface of the liquid may be ejected by the impulse. Since all ferrofluid grains possess a coating of the liquid host, the ejected grain can be used as an ink-drop, with typical diameter of 15 or so nanometers. The velocities of the ejecting grains can be controlled and hence the method, if experimentally feasible, may have wide ranging applications. One of these applications is likely to be in designing special-purpose nozzle-free inkjet printers of unprecedented resolution.