bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping long term with active suicide in adolescents: Results from a pilot randomized controlled trial
Authors: Yen Shirley , Spirito Anthony , Weinstock Lauren M , Tezanos Katherine , Kolobaric Antonija , Miller Ivan 
Published: May 2019

Background: To adapt the Coping Long Term with Active Suicide Program (CLASP) for use with adolescents (CLASP-A) and to assess its feasibility and acceptability on an inpatient psychiatric unit. CLASP-A entailed three individual sessions and one family session, followed by a series of outpatient phone calls to adolescent and a designated parent/guardian over 6 months of follow-up. Methods: The open trial phase involved 17 adolescent/parent pairs, followed by a pilot randomized controlled trial (RCT) in which adolescent/parent pairs were randomized to CLASP-A ( n = 25) or enhanced treatment as usual (ETAU; n = 25). Assessments were completed at baseline, 3- and 6-month follow-ups. Results: In the open trial, average in-person session attendance was 67%, and study treatment satisfaction was high. To enhance feasibility, we adapted CLASP-A to be completed in three individual sessions for the RCT; 77% of the sessions were completed and study satisfaction remained high in adolescents (3.32/4.0) and parents (3.62/4.0). There were no significant differences between groups in number of suicide attempts or readmissions during follow-up. Conclusion: Data indicate feasibility and acceptability of CLASP-A. However, the absence of treatment effects between groups raises questions regarding CLASP’s potential efficacy with adolescents or the need for more extensive adaptations for adolescents.
Proposed classification of endoleaks after endovascular treatment of Stanford type-B aortic dissections
Authors: Sharafuddin Mel J , Reece T Brett , Papia Giuseppe , Pozeg Zlatko I , Peterson Brian G , Shafi Bilal , Man Jeanette , Milner Ross 
Published: May 2019

Objectives Despite two decades of experience, no dedicated classification system exists to document and prognosticate patterns of endoleak encountered after endovascular therapy of type-B aortic dissection. This nomenclature gap has led to inconsistent management and underreporting of significant findings associated with adverse outcomes after endovascular treatment of type-B aortic dissection. Our goal was to propose a reproducible and prognostically relevant classification. Methods A multidisciplinary team of seven experienced open and endovascular aortic surgeons was assembled to provide consensus opinion. Extensive literature review was conducted. Deficiencies in the current classification approach of the various patterns of persistent filling of false lumen after endovascular therapy were identified. Results Our focus was to categorize high-risk and low-risk subgroups within endoleaks after endovascular treatment of type-B aortic dissection. In this classification, type-Ia endoleak refers to persistent filling of the false lumen in an antegrade manner. Causes include failure to cover the primary entry tear and sizing or technical related proximal seal failure. False lumen filling via distal entry tears is classified as type Ib endoleak, which is further sub-classified into b1 (major branch-related tears), and b2 (multiple small branches related tears). Retrograde ascending aortic dissection and stent graft-induced new entry were classified as type-I endoleaks (type-Ir and type-Is, respectively). Another focus was reclassification type-II endoleaks, with type-IIa endoleak referring to conventional retroleak from one or more posterior branches and type-IIx referring to retroleak from major branches (visceral or left subclavian arteries). Conclusions The majority of endoleaks after endovascular treatment of type-B aortic dissection are related to persistent or new filling of the false lumen. We propose a new false lumen-based classification schema for endoleaks occurring after endovascular therapy of type-B aortic dissection.
Cotargeting Plk1 and androgen receptor enhances the therapeutic sensitivity of paclitaxel-resistant prostate cancer
Authors: Shin Sol-Bi , Woo Sang-Uk , Yim Hyungshin 
Published: May 2019

Backgrounds: Despite the clinical success of taxanes, they still have limitations, such as chemoresistance. To overcome the limitations of paclitaxel, genetic alterations and targeting effects of altered genes were observed in paclitaxel-resistant cancer. Because paclitaxel-resistant cancer shows high levels of Plk1, a promising target in chemotherapy, the effectiveness of Plk1 inhibitors in paclitaxel-resistant cancer cells has been investigated. Methods: Paclitaxel-resistant cancer cells were developed by exposure of stepwise escalating levels of paclitaxel. Genetic alterations were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunoblotting. Using a cell viability assay, combined targeting effects for Plk1 and androgen receptor (AR) were determined. Clinical data were analyzed to understand the relationship between Plk1 and AR in prostate cancer patients. Results: Treatment with Plk1 inhibitors markedly reduced the expression of MDR1, MRP1, and Plk1 in the paclitaxel-resistant cancer. Among Plk1 inhibitors, genistein, recently found as a direct Plk1 inhibitor, tended to be more effective in the paclitaxel-resistant prostate cancer than the parental cancer cells, which was related to the suppression of the AR, as well as inhibition of Plk1 activity. A combination of Plk1 inhibitors and AR antagonist bicalutamide exhibited a synergistic effect in LNCaPTXR, as well as LNCaP cells, by inhibiting Plk1 and AR. Analysis of clinical data provides evidence for the relevance between Plk1 and AR in prostate cancer patients, showing that Plk1 and AR are strong predictors of poor survival rates. Conclusions: We suggest that cotargeting Plk1 and AR would be effective in advanced chemoresistant prostate cancer cells to overcome the limitations associated with paclitaxel.
Responding to Intraoperative Neuromonitoring Changes During Pediatric Coronal Spinal Deformity Surgery
Authors: Lewis Stephen J. , Wong Ian H. Y. , Strantzas Samuel , Holmes Laura M. , Vreugdenhil Ian , Bensky Hailey , Nielsen Christopher J. , Zeller Reinhard , Lebel David E. , de Kleuver Marinus , Germscheid Niccole , Alanay Ahmet , Berven Sigurd , Cheung Kenneth M. C. , Ito Manabu , Polly David W. , Shaffrey Christopher I. , Qiu Yong , Lenke Lawrence G. 
Published: May 2019

Study Design: Retrospective case study on prospectively collected data. Objectives: The purpose of this explorative study was: 1) to determine if patterns of spinal cord injury could be detected through intra-operative neuromonitoring (IONM) changes in pediatric patients undergoing spinal deformity corrections, 2) to identify if perfusion based or direct trauma causes of IONM changes could be distinguished, 3) to observe the effects of the interventions performed in response to these events, and 4) to attempt to identify different treatment algorithms for the different causes of IONM alerts. Methods: Prospectively collected neuromonitoring data in pre-established forms on consecutive pediatric patients undergoing coronal spinal deformity surgery at a single center was reviewed. Real-time data was collected on IONM alerts with >50% loss in signal. Patients with alerts were divided into 2 groups: unilateral changes (direct cord trauma), and bilateral MEP changes (cord perfusion deficits). Results: A total of 97 pediatric patients involving 71 females and 26 males with a mean age of 14.9 (11-18) years were included in this study. There were 39 alerts in 27 patients (27.8% overall incidence). All bilateral changes responded to a combination of transfusion, increasing blood pressure, and rod removal. Unilateral changes as a result of direct trauma, mainly during laminotomies for osteotomies, improved with removal of the causative agent. Following corrective actions in response to the alerts, all cases were completed as planned. Signal returned to near baseline in 20/27 patients at closure, with no new neurological deficits in this series. Conclusion: A high incidence of alerts occurred in this series of cases. Dividing IONM changes into perfusion-based vs direct trauma directed treatment to the offending cause, allowing for safe corrections of the deformities. Patients did not need to recover IONM signal to baseline to have a normal neurological examination.
The story of one diamond: the heterogeneous distribution of the optical centres within a diamond crystal from the Ichetju placer, northern Urals
Authors: Vasilev Evgeny , Petrovsky Vitaly , Kozlov Alexander , Antonov Anton , Kudryavtsev Andrey , Orekhova Ksenia 
Published: May 2019

AbstractWe have investigated a diamond crystal that consists of several misorientated subgrains. The main feature of the crystal is the dark areas in the cathodoluminescent core that has ‘estuary-like’ boundaries extending along the subgrain interfaces. The core has >3100 ppm of nitrogen, and the share of the B form is >95%; the absorbance of the centre N3VH at 3107 cm–1 reaches 75 cm–1. The N3 centre absorbance, as well as N3 luminescence, is absent in the core. In the outer part of the crystal, bright blue luminescence of the N3 centre is apparent, and the N3 absorbance reaches 5.3 cm–1. These observations could be explained by the conversion of N3 centres to N3VH after attaching a hydrogen atom. After the full conversion of the N3 centres, the diamond becomes darker under CL. We hypothesise the dark core has a specific shape due to the post-growth diffusion of the hydrogen.
Numerical study of the effect of cement defects on flexural-wave logging
Authors: Song Ruolong , Dong Hefeng , Bao Xueshan 
Published: May 2019

Cement-bond evaluation is needed for new wells and plug and abandonment activities. The ultrasonic leaky Lamb-wave (also called the flexural-wave) technique, in combination with the pulse-echo technique, has been widely used for cement-quality evaluation. Using a 2D time-domain staggered-grid stress-velocity finite-difference methodology, we have numerically investigated the attenuation and group velocity of flexural waves, and the scattering from defects, in the presence of a water-filled void in the cement annulus. The position, length, thickness, and burial depth of a defect are considered. The numerical study suggests that the combination of the attenuation and group velocity of the flexural wave allows for a discrimination between solids and liquids. The scattering from voids can be used to indicate the existence of a hidden defect, which cannot be detected by using the attenuation and group velocity if it is located larger than 5 mm away from the casing. The void signatures can even be used to characterize the geometry of the defect for neat cement. The numerical results provide improved understanding of flexural-wave logging results.
Inclusive Innovation: Product Innovation in Technology Supply Chains
Authors: Vish Krishnan Viswanathan , Lee Junghee , Mnyshenko Oleksiy , Shin Hyoduk 
Published: May 2019

Problem definition: Managers introducing new innovative technological products frequently face the dual task of managing both revenues and profits. This task is made challenging in part because of the tendency of new technologies to traverse a sequentially downward path of gradually lowering costs and prices, which limits their initial availability and affordability, crimping market coverage and revenues. Academic/practical relevance: We focus on the product management challenge of juggling revenues and profits, show how it is amplified in a supply chain, and propose a new degree of freedom in a supply chain, namely innovation investment anchoring, that offers product managers and their firms the ability to expand market coverage and improve both revenues and profits. Methodology: We adopt a sequential game theory approach to analyze the investment anchor decision for various objectives from investments in innovation to market coverage to profit. Results: We find that the investment anchoring approach can lead to greater investments in innovation, revenues, and profits. We also compare the investment anchoring for two types of innovation, product quality improvement and cost reduction, and show that the investment anchoring is more effective for product quality improvement. Managerial implications: Our findings have subtle but important implications for firms launching innovative products and aspiring to expand product sales and profits. Specifically, innovating firms in a supply chain by broadening the quest for an investment anchor and offering them incentives to invest as well as fine tuning the level of innovation investment with the market context can make innovation more inclusive, alleviate supply chain distortions, and streamline revenues and profits. The online appendix is available at https://doi.org/10.1287/msom.2018.0746 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Value Chain Innovations in Developing Economies.
Antibacterial activity of Pakistani Beri honey compared with silver sulfadiazine on infected wounds: a clinical trial
Authors: Yousaf Iram , Ishaq Irfan , Hussain Muhammad Barkaat , Inaam Saima , Saleem Sidrah , Qamar Muhammad Usman 
Published: May 2019

Objective: To determine the antibacterial activity of Pakistani Beri honey in patients with infected wounds in comparison with silver sulfadiazine. Method: Inpatients with infected wounds at a tertiary care hospital were divided in to three equal-sized treatment groups. In Group A, patients were treated with non-Gamma irradiated Beri honey. In Group B, Gamma irradiated Beri honey was used, and in Group C silver sulfadiazine was used. Treatment was for a period of four weeks. Pus swabs were taken at day zero and weeks one and four of treatment. Bacteria were identified using the analytical profile index system API 20E, 20NE and API Staph and antimicrobial susceptibility was done as per the Clinical and Laboratory Standards Institute 2010 guidelines. Results: A total of 90 patients with wounds (n=90) took part in the trial. Out of 90 wounds, 47% were post-traumatic and 37% were postoperative. Overall, average length, width and depth of Group A patients' wounds were significantly reduced (p<0.0001). Out of 144 pus swabs; 99 and 45 were Gram-negative rods and Gram-positive cocci, respectively. Among these Pseudomonas aeruginosa (n=25) and Staphylococcus aureus (n=38) were the major pathogens. Interestingly, bacterial load gradually decreased from baseline to week four due to non-Gamma irradiated Beri honey. Moreover, both the Gram-negative rods and Gram-positive cocci displayed 100% resistance to commonly used antibiotics; the most effective drugs were carbapenem and vancomycin. Conclusion: Pakistani Beri honey could be used as an alternative therapeutic option for the management of infected wounds.
Tillage Effects on Drainage Fluxes and Nitrate Leaching through Unsaturated Zone under Irrigated Corn-Soybean Rotation
Authors: Jabro J. D. , Iversen W. M. , Stevens W. B. , Sainju U. M. , Allen B. L. 
Published: May 2019

Abstract. High levels of nitrate-nitrogen (NO3-N) in the nation’s groundwater are a significant environmental concern. To date no studies have yet evaluated the effects of various tillage practices on percolated drainage and NO3-N fluxes below the rootzone of cropping systems in the northern Great Plains. A field study was conducted to examine and compare the effect of no-tillage (NT) and conventional tillage (CT) practices on seasonal drainage fluxes and NO3-N leaching losses below the rootzone in irrigated corn ( L.) and soybean ( L.) on a Lihen sandy loam soil. Sixteen passive capillary lysimeters, PCAPs (75 cm long polyvinyl chloride pipe with a collecting surface area of 0.1 m2) were placed 90 cm below the soil surface to quantify percolated drainage water below the rootzone of corn-soybean rotation under NT and CT practices. The study was designed as a randomized complete block with four replications. Drainage and NO3-N fluxes were not significantly affected by the tillage in 2014, 2015, 2016, and 2017 due to substantial spatial variations among lysimeters within each treatment. Average cumulative seasonal drainage depths across 4 years were 22.26 and 34.46 mm for corn and 24.95 and 28.16 mm for soybean under NT and CT, respectively. Averaged 4-yr cumulative NO3-N losses were 17.61 and 26.74 kg ha-1 for corn and 25.47 and 23.56 kg ha-1 for soybean under NT and CT, respectively. Flow-weighted NO3-N concentrations over 4 years were 57.9 and 65.7 mg L-1 for corn while those for soybean were 74.8 and 67.0 mg L-1 under NT and CT, respectively. Nitrate-nitrogen concentrations generally exceed the safe drinking water standard of 10 mg L-1. Reducing N inputs in well-drained soils and using site specific N and irrigation management practices are required to lower input expenses, reduce N leaching losses and sustain environmental quality. Keywords: Drainage, Fluxes, Leaching, Lysimeter, Nitrate-nitrogen, Rootzone, Tillage.
Karakteristik sampah mikroplastik di Muara Sungai DKI Jakarta
Authors: Rahmat Sapta L.J , Purba Noir P , Agung Mochamad U.K. , Yuliadi Lintang P.S. 
Published: May 2019

Abstract. Marine debris is one of the global issues and becomes a challenge for Indonesia as a maritime country. This research focuses on the characteristics of the one the estuaries in DKI Jakarta. The method used in this research by sampling the water at the mouth of the river by using the manta net at different depths and in tidal conditions. The results showed that the number of microplastic consists of 93 microplastic particles originating from the seven stations. The number of microplastic particles at low tide conditions is 112 particles. The results of microplastic counting obtained weight of 45.7 mg from the seven stations with high tide conditions on the surface. The maximum particle weight value of 16.2 mg found at station 1 in Muara Tiram. Based on the observations at each station, the size of the microplastic obtained range between 1mm to 5mm. The results of observing the characteristics of the forms in the research study have results including fragments, filaments, films, foams, and granules. The microplastics at the estuary come from the ocean and also from the river.Keywords: marine debris, estuary, microplastics, rivers, trash education Abstrak. Sampah laut merupakan isu global dan merupakan tantangan bagi Indonesia sebagai negara maritim. Penelitian ini dilakukan untuk mengetahui bagaimana karakteristik sampah yang keluar dari muara sungai di DKI Jakarta. Metode yang digunakan adalah dengan melakukan sampling di muara sungai dengan menggunakan manta net pada kedalaman yang berbeda dan pada kondisi pasang dan surut. Hasil penelitian menunjukkan bahwa jumlah mikroplastik sebanyak 93 partikel mikroplastik yang berasal dari tujuh stasiun. Hasil yang berbeda terlihat pada kondisi surut di permukaan terdapat jumlah sebanyak 112 partikel mikroplastik. Hasil pencacahan mikroplastik didapatkan berat sebesar 45,7 mg yang berasal dari ketujuh stasiun dengan kondisi pasang yang berada di permukaan. Nilai berat partikel maksimum sebesar 16,2 mg yang terdapat pada stasiun 1 di Muara Tiram. Berdasarkan pengamatan yang dilakukan di setiap stasiun, menunjukkan bahwa pengukuran partikel mikroplastik memiliki karakterisasi ukuran sampah yaitu antara 1mm hingga 5 mm. Hasil pengamatan karakteristik bentuk pada kajian penelitian memiliki hasil diantaranya yaitu fragments, filaments, films, foams, dan granules. Sampah yang ada di estuary dapat berasal dari laut dan juga dari sungai.Kata Kunci: sampah laut, estuarin, mikroplastik, sungai, edukasi sampah
Performa pertumbuhan bawal bintang Trachinotus blochii yang dibudidaya dengan sistem monokultur dan polikultur bersama kerang hijau Perna viridis
Authors: Hidayat Kurnopriawan , Yulianto Herman , Ali Mahrus , Noor Nuning Mahmudah , Putri Berta 
Published: May 2019

Abstract. The snubnose pompano Trachinotus blochii is one of the important commercial fishery commodity in the Indonesian market. The increasing of the market demand has led some efforts to increase the production of this fish. So do the increasing need for green mussels Perna viridis meat. Therefore it is necessary to evaluate the performance of both species in the polyculture system by using raft culture. This study aims to compare the growth performance of snubnose pompano cultivated on a monoculture system and polyculture within green mussels in a raft system. The parameter observed was the differences in the growth performance of both species and the increase in total weight and survival (SR) of the fish. The results showed that the growth of snubnose pompano did not provide a significant difference in the growth of both cultivating systems whether in monoculture or polyculture system, likewise the shell length and width of the green mussels. We conclude that it is profitable to cultivate both organisms on a polyculture system because it can harvest both green mussels and snubnose pompano together in a period.Keywords: Snubnose pompano, green mussel, monoculture, polyculture, raft, growth Abstrak. Permintaan pasar terhadap daging ikan bawal bintang semakin meningkat begitupun dengan daging kerang hijau sehingga diperlukan suatu upaya rekayasa teknologi budidaya. Salah satunya adalah dengan menerapkan sistem polikultur dalam keramba jaring apung. Penelitian ini bertujuan membandingkan faktor pertumbuhan ikan bawal bintang dan kerang hijau yang dibudidayakan dengan sistem monokultur dan polikultur. Pengamatan dilakukan pada perbedaan pertumbuhan ikan dan kerang hijau, juga pada mutlak serta survival rate (SR). Hasil penelitian menunjukkan bahwa pertumbuhan panjang dan lebar bawal bintang tidak memberikan perbedaan pertumbuhan secara nyata baik pada perlakuan monokultur dan polikultur. Begitupun dengan pertumbuhan kerang hijau sehingga sistem polikultur lebih menguntungkan untuk dilakukan karena bisa memanen kerang hijau dan ikan bawal bintang sekaligus.Kata Kunci: kerang hijau, ikan bawal bintang, monokutur, polikultur, pertumbuhan, KJA.