bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mogroside V Inhibits Hyperglycemia-induced Lung Cancer Cells Metastasis through Reversing EMT and Damaging Cytoskeleton
Authors: Chen Jun , Jiao Demin , Li Yu , Jiang Chunyan , Tang Xiali , Song Jia , Chen Qingyong 
Published: June 2019

Background:
Diabetes Mellitus (DM) accelerates progress of lung cancer. Hyperglycemia,
a critical feature of DM, promotes lung cancer metastasis. Mogroside V is a triterpenoid glycoside
from Siraitia grosvenorii. Interestingly, mogroside V not only plays an anti-diabetic role, but
also has anti-tumor effects.

Objective:
In this study, we investigated the metastatic efficiency of mogroside V in lung cancer
cells cultured in hyperglycemia.

Methods:
Two lung cancer cell lines-A549 and H1299 were cultured in normoglycemia (5.5mM
glucose) and hyperglycemia (25mM glucose). Cellular proliferation was tested by MTT, invasion
was examined by transwell assay, migration was measured by wound healing assay, cytoskeleton
was stained by Phalloidin-TRITC and the expressions of EMT markers and Rho-GTPase family protein
were detected by western blot.

Results:
Hyperglycemia promoted the invasion and migration of A549 and H1299 cells compared
with normoglycemia. Mogroside V inhibited the hyperglycemia-induced invasion and migration.
Hyperglycemia promoted epithelial-mesenchymal transition (EMT), while mogroside V could reverse
this process through up-regulating E-Cadherin expression and down-regulating N-Cadherin,
Vimentin, Snail expressions. Furthermore, mogroside V fractured microfilaments and reduced Rho
A, Rac1, Cdc42 and p-PAK1 expressions under hyperglycemic conditions.

Conclusion:
These results suggest that mogroside V inhibits hyperglycemia-induced lung cancer
cells migration and invasion through reversing EMT and damaging cytoskeleton.
Recent Advances on Ankle Rehabilitation Device
Authors: Tang Dedong , Xiao Limei 
Published: June 2019

Background:
Ankle joint, as one of the important joints supporting the weight of human
body, is vulnerable to injury in daily physical exercise and sports because of its special growth location
and anatomical composition. The rehabilitation period of traumatic ankle is relatively long,
especially in the later period of recovery. In order to relieve the clinical symptoms such as swelling
and pain caused by ankle trauma, the rehabilitation of the ankle should be actively carried out by
means of rehabilitation equipment. Thus, the ankle rehabilitation cycle can be minimized largely
and the rehabilitation efficiency can be improved greatly.

Objective:
Through the summary of the latest literature on ankle rehabilitation devices, readers will
be familiar with the research progress and difficulties in this field, and the reference for the followup
study in this direction is provided.

Methods:
The structural characteristics and applications of the ankle rehabilitation devices are introduced
in the paper. The latest patents and articles related to ankle rehabilitation device are compared
and analyzed.

Results:
The ankle rehabilitation devices are classified according to the structure characteristics,
driving mode and training function. The advantages and disadvantages of various devices are
pointed out, and the future development direction of this research field is predicted.

Conclusion:
Studies show that remarkable improvements have been achieved on the ankle rehabilitation
equipment. In the future, the structural optimization, new materials, control strategy, new type
actuators, and rehabilitation evaluation of ankle rehabilitation devices should be further studied.
Pyridoxine Decreases Oxidative Stress on Human Erythrocyte Membrane Protein in vitro
Authors: Velásquez Margarita , Méndez Darío , Moneriz Carlos 
Published: June 2019

Background:
Pyridoxine has reduction and prevention against the levels of reactive oxygen species in in vitro studies. However, the biochemical mechanism that explains this behavior has not yet been fully clarified.

Objective:

To evaluate the effect of pyridoxine against oxidative damage on the membrane of human erythrocytes.

Methods:
Cumene hydroperoxide was used to induce oxidative stress in protein and lipid. Human erythrocytes were incubated with pyridoxine and cumene hydroperoxide, either alone or together for 8 h. Oxidative damage was determined by measuring lipid peroxidation and membrane protein carbonylation.

Results:
The results indicate that the malondialdehyde concentration decreased with increasing concentration of pyridoxine. The membrane protein content also decreased with increasing concentration of vitamin B6, which was confirmed by the decreased signal intensity in the western blot when compared to control without pyridoxine. Results demonstrate that pyridoxine can significantly decrease lipid peroxidation and protein carbonylation in red cell membrane exposed to high concentrations of oxidant agent.

Conclusion:
Pyridoxine showed a protective effect against the oxidative stress in human erythrocytes in vitro, inhibiting the carbonylation and the oxidative damage of erythrocyte membrane proteins. To date, such an effect has not yet been reported in terms of protein oxidation.
Creating a Gain Improvement Technique for a Horn Antenna using a Metamaterial Structure Inserted with a Thin Dielectric Sheet
Authors: Kamphikul Paowphattra , Mankong Ukrit , Wongsan Rangsan 
Published: June 2019

Objective:
This paper proposed a new technique for the metamaterial on the structure of the curved-woodpile Electromagnetic Band Gap (EBG) inserted with a dielectric slab for gain improvement in a conventional rectangular horn antenna.

Methods:
We described a method to enhance gain by transferring the electromagnetic fields from the aperture of a horn through the EBG structure. Furthermore, we present the design procedures for inserting a dielectric slab into two layers of the EBG structure for the reduction of distance between the horn and proposed EBG structure.

Results and Conclusions:
Such a proposed technique not only has the advantage of decreasing the total length of the antenna system but also providing higher gain with a low profile structure.
This idea has been verified by both simulation and experimental results. The fabricated antenna can achieve 23.9 dBi of gain or higher than the gain, which is obtained using a conventional rectangular horn antenna at around 7 dBi at an operating frequency of 10 GHz. It is apparent that a good qualitative agreement between the measurements and simulations was achieved.
Antioxidant Activity and Phenolic Content of Campomanesia Phaea Extracts Obtained by Pressurized Liquid Extraction
Authors: Firmiano Daniele Martins , Bittencourt Gabriela Marques , Lopes de Oliveira Alessandra 
Published: June 2019

Objective:This research used the Pressurized Liquid Extraction process (PLE) to obtain cambuci extracts rich in phenolic compounds and, consequently, with high antioxidant activity.Methods:We determined the centesimal composition and the mean particle size of the dried and crushed sample for characterization of the fixed bed extractor. Extractions with pressurized ethanol were performed following a Central Composite Design (CCD) with temperature (60 °C at the center point with ± 10 °C amplitude) and the contact time between the solvent and the matrix (6 min at the center point with ± 2 min amplitude) as independent variables in the process. The Total Phenolic Content (TPC) of compounds and antioxidant activity were determined.Results:The mean particle size of the cambuci in the PLE was 263.4 μm with apparent and real densities of 32.42 g/cm3and 1.62 g/cm3, respectively, resulting in a fixed bed porosity of 0.43. The centesimal composition of the comminuted and dried sample was 12.5 ± 0.1% moisture, 3.2 ± 0.2% ash, 3.35 ± 0.07% crude protein, 10.32 ± 0.08% crude fiber and 0.35 ± 0.04% ethereal extract. The highest extraction yield (41.7%) was obtained by using the binomial 70 ºC with 8 min of solvent contact in three batches. Extracts with the highest TPC (6501.10 mg AGE/100 g sample) were obtained by the binomial 74 °C with 6 min of contact; the binomial 50 °C with 4 min of contact gave rise to the extract with the highest antioxidant activity. The CCD showed high yield extracts with high antioxidant activity and a high total phenolic compound content.Conclusion:With the use of the proposed experimental design, it was possible to optimize the extraction of total phenolic compounds from the sample.
Phytochemical Investigation and Antimutagenic Potential of Ethanolic Extracts of Emblica officinalis, Terminalia chebula and Terminalia bellirica
Authors: Singamaneni Venugopal , Dokuparthi Sudheer Kumar , Banerjee Nilanjana , Kumar Ashish , Chakrabarti Tulika 
Published: June 2019

Background:
Emblica officinalis Gaertn. which belongs to the family Euphorbiaceae,
Terminalia chebula Retz. and Terminalia bellerica Roxb. belong to the family Combretaceae. These
are well known medicinal plants with phytochemical reservoir of great medicinal values and possess
a vast ethnomedical history.

Objective:
The aim of the present study is to isolation of major compounds and to evaluate antimutagenic
potential of the ethanol extracts of these plants.

Methods:
The dried fruits of E. officinalis, T. bellirica and T. chebula were powdered and extracted
with 95% ethanol. The ethyl acetate portions were chromatographed over silica gel to isolate major
compounds. Antimutagenic activity was determined by Ames test using TA98 and TA100 strains of
Salmonella typhimurium.

Results:
Two major known compounds, gallic acid and ellagic acid were isolated from the dried
fruits of Emblica officinalis, Terminalia chebula and T. bellirica. All the three extracts counteracted
the mutagenicity induced by different genotoxic compounds in a dose dependent manner.

Conclusion:
This study showed that ethyl acetate portion of three extracts contain two major compounds,
gallic acid and ellagic acid which might be responsible for potent antimutagenic activity of
these extracts.
Collaborative Packet Dropping Intrusion Detection in MANETs
Authors: Ginnela Gopichand , Saravanaguru Ramaiah Kannan 
Published: June 2019

Background:
Wireless Networks treat Mobile Ad hoc Network as a network that requires no preexisting
infrastructure for setting up the network and is self-organized dynamically, which is made on impermanent
basis. Before transmitting the packets from the source to the destination node, route is searched to
the destination node from the source node. Due to the absence of special routers in this network, the nodes
themselves act as routers and co-operates in performing the routing mechanism. During the packet dispatch
to the destination from the source, there might be a critical attack which leads to the dropping of the packet.
This dropping of packets is the most popular risks in mobile ad hoc networks.

Objective:
To find a detection mechanism for collaborative packet dropping in Mobile Ad hoc network.

Methods:
The proposed work refers to the diverse properties of collective packet dropping intrusions and
scrutinizes the classes of proposed protocols with specific topographies warehoused in wireless ad hoc networks.

Results:
The results of End-to-End delay shows that Mobile Ad hoc Network beneath supportive black hole
intrusion had a minor decrease and are more efficient in terms of performance.

Conclusion:
In this paper, we mainly engrossed on the special routing protocols existing in MANET like
AODV, DSR, and DSDV in detecting the packet dropping attack in a MANET. Hence we refer to the diverse
stuffs in collaborative packet dropping attacks and scrutinize classifications of proposed protocols with
certain configurations warehoused in mobile ad hoc networks.
Mobile Apps for the Care Management of Chronic Kidney and End-Stage Renal Diseases: Systematic Search in App Stores and Evaluation
Authors: Siddique Abu Bakkar , Krebs Mary , Alvarez Sarai , Greenspan Iris , Patel Amit , Kinsolving Julianna , Koizumi Naoru 
Published: June 2019

Background
Numerous free and low-cost mobile apps for the care management of kidney disease have become available in recent years. Although these appear to be promising tools, they have not been evaluated comparatively based on standard mobile app metrics, and thus, limited evidence is available regarding their efficacy. This study systematically cataloged and assessed mobile apps designed to assist medication compliance and nutrition tracking that are useful to the chronic kidney disease (CKD) and the end-stage renal disease (ESRD) patients who are on dialysis.

Objective
The objective of this study was to comprehensively evaluate mobile apps used for medication compliance and nutrition tracking for possible use by CKD and ESRD patients.

Methods
A systematic review framework was applied to the search, screening, and assessment of apps identified and downloaded from the iOS and Android app stores. We selected apps using 13 relevant search terms, narrowed down based on a set of inclusion and exclusion criteria, and then used the Mobile App Rating Scale (MARS), a widely adopted app evaluation tool to assess the effectiveness of apps. The internal consistency and interrater reliability were tested using Cronbach alpha and interclass correlation coefficients (ICCs), respectively.

Results
The MARS total score had excellent internal consistency (Cronbach alpha=.90) and a moderate level of interrater reliability (2-way mixed ICC 0.65). Overall, 11 out of the 12 reviewed apps met the minimum acceptable score of 3.0 in MARS rating. The 3 apps with the highest combined scores were My Kidneys, My Health Handbook (MARS=4.68); My Food Coach (MARS=4.48); and National Kidney Foundation Malaysia (MARS=4.20). The study identified 2 general weaknesses in the existing apps: the apps fell short of accommodating advanced interactive features such as providing motivational feedback and promoting family member and caregiver participations in the app utilization.

Conclusions
The MARS rating system performed well in the app evaluation. The 3 highest ranked apps scored consistently high across the 5 dimensions specified in MARS. These apps were developed in collaboration with reputable organizations and field experts, demonstrating the importance of expert guidance in developing medical apps.
Multimodal Human and Environmental Sensing for Longitudinal Behavioral Studies in Naturalistic Settings: Framework for Sensor Selection, Deployment, and Management
Authors: Booth Brandon M , Mundnich Karel , Feng Tiantian , Nadarajan Amrutha , Falk Tiago H , Villatte Jennifer L , Ferrara Emilio , Narayanan Shrikanth 
Published: June 2019

BackgroundRecent advances in mobile technologies for sensing human biosignals are empowering researchers to collect real-world data outside of the laboratory, in natural settings where participants can perform their daily activities with minimal disruption. These new sensing opportunities usher a host of challenges and constraints for both researchers and participants.ObjectiveThis viewpoint paper aims to provide a comprehensive guide to aid research teams in the selection and management of sensors before beginning and while conducting human behavior studies in the wild. The guide aims to help researchers achieve satisfactory participant compliance and minimize the number of unexpected procedural outcomes.MethodsThis paper presents a collection of challenges, consideration criteria, and potential solutions for enabling researchers to select and manage appropriate sensors for their research studies. It explains a general data collection framework suitable for use with modern consumer sensors, enabling researchers to address many of the described challenges. In addition, it provides a description of the criteria affecting sensor selection, management, and integration that researchers should consider before beginning human behavior studies involving sensors. On the basis of a survey conducted in mid-2018, this paper further illustrates an organized snapshot of consumer-grade human sensing technologies that can be used for human behavior research in natural settings.ResultsThe research team applied the collection of methods and criteria to a case study aimed at predicting the well-being of nurses and other staff in a hospital. Average daily compliance for sensor usage measured by the presence of data exceeding half the total possible hours each day was about 65%, yielding over 355,000 hours of usable sensor data across 212 participants. A total of 6 notable unexpected events occurred during the data collection period, all of which had minimal impact on the research project.ConclusionsThe satisfactory compliance rates and minimal impact of unexpected events during the case study suggest that the challenges, criteria, methods, and mitigation strategies presented as a guide for researchers are helpful for sensor selection and management in longitudinal human behavior studies in the wild.
Exploring the Patterns of Use and Acceptability of Mobile Phones Among People Living With HIV to Improve Care and Treatment: Cross-Sectional Study in Three Francophone West African Countries
Authors: Lepère Phillipe , Touré Yélamikan , Bitty-Anderson Alexandra M , Boni Simon P , Anago Gildas , Tchounga Boris , Touré Pendadiago , Minga Albert , Messou Eugène , Kanga Guillaume , Koule Serge , Poda Armel , Calmy Alexandra , Ekouevi Didier K , Coffie Patrick A 
Published: June 2019

Background
The use of mobile technology in health care (mobile health [mHealth]) could be an innovative way to improve health care, especially for increasing retention in HIV care and adherence to treatment. However, there is a scarcity of studies on mHealth among people living with HIV (PLHIV) in West and Central Africa.

Objective
The aim of this study was to assess the acceptability of an mHealth intervention among PLHIV in three countries of West Africa.

Methods
A cross-sectional study among PLHIV was conducted in 2017 in three francophone West African countries: Côte d’Ivoire, Burkina Faso, and Togo. PLHIV followed in the six preselected HIV treatment and care centers, completed a standardized questionnaire on mobile phone possession, acceptability of mobile phone for HIV care and treatment, preference of mobile phone services, and phone sharing. Descriptive statistics and logistic regression were used to describe variables and assess factors associated with mHealth acceptability.

Results
A total of 1131 PLHIV—643 from Côte d’Ivoire, 239 from Togo, and 249 from Burkina Faso—participated in the study. Median age was 44 years, and 76.1% were women (n=861). Almost all participants owned a mobile phone (n=1107, 97.9%), and 12.6% (n=140) shared phones with a third party. Acceptability of mHealth was 98.8%, with the majority indicating their preference for both phone calls and text messages. Factors associated with mHealth acceptability were having a primary school education or no education (adjusted odds ratio=7.15, 95% CI 5.05-10.12; P<.001) and waiting over one hour before meeting a medical doctor on appointment day (adjusted odds ratio=1.84, 95% CI 1.30-2.62; P=.01).

Conclusions
The use of mHealth in HIV treatment and care is highly acceptable among PLHIV and should be considered a viable tool to allow West and Central African countries to achieve the Joint United Nations Programme on HIV/AIDS 90-90-90 goals.
Relationship between alexithymia and career decision -making self-efficacy among Tenth and Eleventh grade students in Muscat governorate
Authors: Hammoud Mohammad Sheikh , Bakkar Bakkar S. , Shendi Yousef Abdulqader Abu , Al Rujaibi Yousuf Saif 
Published: June 2019

The purpose of this study was to examine the relationship between alexithymia and career decision -making self-efficacy among Tenth and Eleventh grade students in Muscat governorate. To achieve this purpose, Alexithymia Scale (AS),and CDMSE Short Form were administered to a total sample of 556 students of Tenth and Eleventh grades ( (n = 278) males and (n = 278) females . Findings revealed that the level of alexithymia was less than the mean of items, while the level of CDMSE was more than the mean of items, as well as there was no significant correlational relationship between alexithymia and CDMSE. The findings also indicated that there were significant gender differences in alexithymia, while there were no significant gender differences in CDMSE. With regard to GPA, the findings revealed that there were no significant differences in alexithymia, while there were significant differences in CDMSE. Conclusion: It concludes that although there was no significant correlational relationship between alexithymia and career decision-making self-efficacy, alexithymia negatively affects individual’s decisions in life.
Ensimmäinen kielitieteellinen väitöskirja Kalle Päätalon tuotannosta
Authors: Lappalainen Hanna 
Published: June 2019

Arvioitu teos:
Sari Keskimaa: Kalle Päätalon Iijoki-sarja kielielämäkertana. Acta Universitatis Ouluensis B Humaniora 165. Oulu: Oulun yliopisto 2018. Johdanto 101 s., artikkelit 121 s. isbn 978-952-62-2053-6.
Toiminnan keskeytymisen ja toimintaan palaamisen multimodaaliset käytänteet englannin- ja suomenkielisessä vuorovaikutuksessa
Authors: Helisten Marika 
Published: June 2019

Marika Helistenin englantilaisen filologian alaan kuuluva väitös tarkastettiin Oulun yliopistossa 2. marraskuuta 2018. Vastaväittäjä toimi professori Mathias Broth Linköpingin yliopistosta ja kustoksena professori Tiina Keisanen.
Marika Helisten: Participants’ multimodal practices for managing activity suspensions and resumptions in English and Finnish interaction. Acta Universitatis Ouluensis. Series B Humaniora 167. Oulu: Oulun yliopisto 2018. Kirja on luettavissa osoitteessa http://urn.fi/urn:isbn:9789526220901.
STRATEGI CALEG DALAM MERAIH DUKUNGAN POLITIK DI KOTA METRO TAHUN 2014
Authors: Hawari Nadirsah 
Published: June 2019

Pada pemilu 2014 silam, sejumlah calon anggota dewan (caleg) mengadu nasib dalam proses politik di tingkat kecamatan di Kota Metro melalui jalur partai politik. Sesuai dengan aturan pemilu yang ada bahwa semua anggota diberikan waktu dan kesempatan untuk bersosialisasi dengan calon pemilih sesuai dengan cara dan pendekatan masing- masing selama tidak melanggar aturan pemilu yang ada. Berbagai bentuk komunikasi politik dan pendekatan dilakukan oleh semua kandidat untuk meraih suara. Diantara strategi yang digunakan oleh para kandidat diantaranya adalah dengan melakukan pendekatan politik identitas, kesukuan, etnis, keagamaan dan pendewasaan politik serta pendekatan pragmatis terutama dengan pemberian, janji, hadiah dan yang lainnya. Hasil olah data didapati bahwa mayoritas pemilih terlibat dengan politik pragmatis alias money politic dan kebanyakan dari mereka terpilih menjadi anggota dewan pada. Dan jika ditelisik sebab utama dari maraknya praktek money politik pada pemilu legislatif di kota Metro disebabkan oleh kecilnya jumlah DPT dan batas minimal suara untuk mendapatkan kursi pada setiap DAPIL sehingga seorang politikus bisa mengkalkulasikannya secara pragmatis.
Book Review: Re-Membering the Black Atlantic: on the Poetics and Politics of Literary Memory by Lars Eckstein (2006)
Authors: Nefnouf Ahmed Seif Eddine 
Published: June 2019

Eckstein (2006) notes that the Atlantic slave trade has continuously haunted the cultural memories of Europe, Africa, and America. In fact, everyone wishes to forget about it. Many of the victims of the African origin tried to run away from the sites that they got traumatized, while those who were enlightened especially, the Westerners preferred to remain unconscious to these upsetting complicity between slavery and enlightenment. In the last few years, many fiction writers have made a decision to venture in re-membering the Black Atlantic.