bluuebunny/crossref_metadata_2025_split huggingface dataset:
High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia
Authors: Hermida Alexis , Fressart Véronique , Hidden‐Lucet Francoise , Donal Erwan , Probst Vincent , Deharo Jean‐Claude , Chevalier Philippe , Klug Didier , Mansencal Nicolas , Delacretaz Etienne , Cosnay Pierre , Scanu Patrice , Extramiana Fabrice , Keller Dagmar I. , Rouanet Stephanie , Charron Philippe , Gandjbakhch Estelle 
Published: February 2019

BackgroundPrevious studies suggested that genetic status affects the clinical course of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) patients. The aim of this study was to compare the outcome of desmoglein‐2 (DSG2) mutation carriers to those who carry the plakophilin‐2 (PKP2) mutation, the most common ARVC/D‐associated gene.Methods and resultsConsecutive ARVC/D patients carrying a pathogenic mutation in PKP2 or DSG2 were selected from a national ARVC/D registry. The cumulative freedom from sustained ventricular arrhythmia and cardiac transplantation/death from heart failure (HF) during follow‐up was assessed, compared between PKP2 and DSG2, and predictors for ventricular arrhythmia and HF events determined. Overall, 118 patients from 78 families were included: 27 (23%) carried a DSG2 mutation and 91 (77%) a PKP2 mutation. There were no significant differences between DSG2 and PKP2 mutation carriers concerning gender, proband status, age at diagnosis, T‐wave inversion, or right ventricular dysfunction at baseline. DSG2 patients displayed more frequent epsilon wave (37% vs. 17%, P = 0.048) and left ventricular dysfunction at diagnosis (54% vs. 10%, P < 0.001). During a median follow‐up of 5.6 years (2.5–16), DSG2 and PKP2 mutation carriers displayed a similar risk of sustained ventricular arrhythmia (log‐rank P = 0.20), but DSG2 mutation carriers were at higher risk of transplantation/HF‐related death (log‐rank P < 0.001). The presence of a DSG2 mutation vs. PKP2 mutation was a predictor of transplantation/HF‐related death in univariate Cox analysis (P = 0.0005).ConclusionsIn this multicentre cohort, DSG2 mutation carriers were found to be at high risk of end‐stage HF compared to PKP2 mutation carriers, supporting careful haemodynamic monitoring of these patients. The benefit of early HF treatment needs to be assessed in DSG2 carriers.
Can Tenax Extraction Be Used as a Surrogate Exposure Metric for Laboratory-Based Bioaccumulation Tests Using Marine Sediments?
Authors: Sinche Federico L. , Lotufo Guilherme R. , Landrum Peter , Lydy Michael J. 
Published: February 2019

Abstract
The Tenax technique was used as an alternative exposure metric to assess the bioavailability of polychlorinated biphenyls (PCBs) from contaminated marine sediments. The sediments used were collected from 2 Superfund sites, New Bedford Harbor (MA, USA) and Gould Island (RI, USA). No sieving was conducted for either sediment after arrival, and sediments were stored in stainless steel drums at 2.8 to 4.0 °C in the dark until use. Exhaustive chemical extractions, single-point 24-h Tenax extractions, and 14-d bioaccumulation tests using the amphipod Leptocheirus plumulosus were conducted for both sediments. The sum of 119 PCB congeners from total exhaustive chemical extraction in the New Bedford Harbor and Gould Island sediments were 1084 and 188.2 µg/g organic carbon, respectively. The PCB concentrations from the bioaccumulation tests and Tenax extractions showed that both exposure metrics followed a similar trend in amount and distribution of PCB congeners. The results from both exposure metrics were fit into a log–log linear regression, and then compared with a previously developed log–log linear model for freshwater organisms. The results showed that although the marine data fell within the prediction intervals of the freshwater linear model, the marine regression followed a lower trajectory due to the differences in both the slopes and intercepts between the marine and freshwater regressions. The present study showed a strong relationship between Tenax and marine invertebrate PCB concentrations. Environ Toxicol Chem 2019;38:1188–1197. © 2019 SETAC
Catch and Release: The Effectiveness of an Educational Class for Anglers Caught with Fishing Citations
Authors: Saul Steven , Capielo Rosario Cristalís 
Published: February 2019

Abstract
Formal regulatory structures, such as government-imposed size limits or bag limits, are standard tools used by managers to achieve fisheries management in most countries. Regulations are most effective if followed by the angling community, which is predicated upon anglers understanding and accepting the regulations. To enhance compliance with fishing regulations and improve the management of fisheries resources, Biscayne and Everglades National Parks established a Fisheries Education Class program that was open to the community and available to anglers cited with a fishing violation in exchange for a reduced or waived fine. Here, we describe this program and quantitatively evaluate its effectiveness by measuring and comparing the self-efficacy and attitudes of participants before and after the class using generalized linear models with repeated measures. Results showed that the Fisheries Education Class was effective at improving the self-efficacy of anglers toward understanding and applying the regulations and improved the attitudes of the participants toward fishing regulations.
Frequentist and Bayesian meta‐regression of health state utilities for multiple myeloma incorporating systematic review and analysis of individual patient data
Authors: Hatswell Anthony J. , Burns Darren , Baio Gianluca , Wadelin Frances 
Published: February 2019

AbstractThis analysis presents the results of a systematic review for health state utilities in multiple myeloma, as well as analysis of over 9,000 observations taken from registry and trial data. The 27 values identified from 13 papers are then synthesised in a frequentist nonparametric bootstrap model and a Bayesian meta‐regression. Results were similar between the frequentist and Bayesian models with low utility on disease diagnosis (approximately 0.55), raising to approximately 0.65 on first line treatment and declining slightly with each subsequent line. Stem cell transplant was also found to be a significant predictor of health‐related quality of life in both individual patient data and meta‐regression, with an increased utility of approximately 0.06 across different models. The work presented demonstrates the feasibility of Bayesian methods for utility meta‐regression, whilst also presenting an internally consistent set of data from the analysis of registry data. To facilitate easy updating of the data and model, data extraction tables and model code are provided as Data S1. The main limitations of the model relate to the low number of studies available, particularly in highly pretreated patients.
National Cancer Database Analysis of the effect of brachytherapy on overall survival in patients with base of tongue cancer
Authors: Silva Scott R. , Martin Brendan , Choi Mehee , Emami Bahman , Hurst Newton J. 
Published: February 2019

AbstractBackgroundWe performed an analysis of the National Cancer Database (NCDB) to evaluate overall survival (OS) in patients with base of tongue (BOT) cancer treated with external beam radiation therapy (EBRT) combined with brachytherapy (BT).MethodsThe tongue NCDB Participant User File was used to obtain demographic and clinical patient data. The Kaplan–Meier method was used to determine OS. Significance was determined using univariable and multivariable Cox proportional hazards models.ResultsAt 3 years, OS was 69.6%, 77.1%, and 63.7% for patients treated with EBRT (n = 27 954), EBRT + BT (n = 209), or BT alone (n = 154), respectively (P = .01). On multivariable analysis, the instantaneous hazard of death for patients receiving EBRT + BT was 25% (Hazard ratio [HR] = 0.75, 95% CI: 0.58‐0.98) lower than patients receiving only EBRT (P = .03).ConclusionsThe addition of BT to EBRT in BOT cancer has an OS benefit.
LOC152742 as a biomarker in the diagnosis of pulmonary tuberculosis infection
Authors: Wang LiMin , Xie BaoQuan , Zhang PanPan , Ge Yanlei , Wang Yuan , Zhang Dan 
Published: February 2019

AbstractAimLong intergenic noncoding RNAs are long noncoding transcripts from the intergenic regions of annotated protein‐coding genes. The elevated expression of long noncoding RNA (lnRNA) LOC152742 has been found in tuberculosis infection yet its roles in antimycobacterial responses remain to be elucidated.Patients and methodsIn this study, the expression levels of LOC152742 in sputum, plasma of normal individuals, active tuberculosis patients, obsolete tuberculosis patients, and individuals affected with bacillus Calmette‐Guerin (BCG) were analyzed by quantitative reverse transcriptase polymerase chain reaction (qRT‐PCR), and the sensitivity and specificity of the candidate biomarker LOC152742 were obtained. At the same time, the expression levels of LOC152742 in pulmonary epithelial and macrophages cells infected with H37Ra or H37Rv were detected by qRT‐PCR.ResultsLOC152742 in sputum and plasma had a higher specificity in active tuberculosis compared with that in obsolete tuberculosis and BCG patients. Additionally, LOC152742 in pulmonary epithelial cells macrophages infected with H37Ra or H37Rv was increased significantly compared with uninfected groups indicating that LOC152742 may potentially act as a novel biomarker for diagnosis and therapy of active tuberculosis.
Bone marrow stromal cells transplantation promotes the resolution and recanalization of deep vein thrombosis in rabbits through regulating macrophage infiltration and angiogenesis
Authors: Zhang Jingyong , Kong Xiangqian , Jin Xing , Gao Peixian , Wang Maohua , Yang Le 
Published: February 2019

AbstractThis study aims to validate whether bone marrow stromal cells (BMSCs) transplantation could promote the resolution and recanalization of deep vein thrombosis (DVT) and to explore the underlying mechanism. The right hind femoral vein was embolized to establish the DVT rabbit model. BMSCs from New Zealand white rabbits were isolated and identified, and then injected into DVT rabbits. After that, the extent of angiogenesis was determined by the amount of capillaries that were positive for antibody against vWF. Macrophage infiltration was measured by immunohistochemistry with F4/80 antibody. M1 or M2 macrophages were identified as F4/80 + CD11c
+ or F4/80 + CD206
+ cells by using flow cytometry analysis, respectively. BMSCs were successfully isolated and identified. BMSCs transplantation promotes macrophage infiltration and angiogenesis in DVT rabbits. BMSCs transplantation causes M1/M2 polarization, altered cytokine production and increased monocyte chemotactic protein 1 (MCP‐1) protein expression in DVT rabbits. However, injection of MCP‐1 protein not only reversed the effects of BMSCs transplantation on macrophage infiltration and angiogenesis, but also reversed the effects of BMSCs transplantation on M1/M2 polarization and cytokine production in DVT rabbits. BMSCs transplantation promotes the resolution and recanalization of DVT in rabbits through regulating macrophage infiltration and angiogenesis, the underlying mechanism is associated with MCP‐1 expression.
A review on coronary artery disease, its risk factors, and therapeutics
Authors: Malakar Arup Kr. , Choudhury Debashree , Halder Binata , Paul Prosenjit , Uddin Arif , Chakraborty Supriyo 
Published: February 2019

AbstractCoronary artery disease (CAD) is one of the major cardiovascular diseases affecting the global human population. This disease has been proved to be the major cause of death in both the developed and developing countries. Lifestyle, environmental factors, and genetic factors pose as risk factors for the development of cardiovascular disease. The prevalence of risk factors among healthy individuals elucidates the probable occurrence of CAD in near future. Genome‐wide association studies have suggested the association of chromosome 9p21.3 in the premature onset of CAD. The risk factors of CAD include diabetes mellitus, hypertension, smoking, hyperlipidemia, obesity, homocystinuria, and psychosocial stress. The eradication and management of CAD has been established through extensive studies and trials. Antiplatelet agents, nitrates, β‐blockers, calcium antagonists, and ranolazine are some of the few therapeutic agents used for the relief of symptomatic angina associated with CAD.
Identification of 8‐miRNAs as biomarkers for nonalcoholic fatty liver disease
Authors: Yu Yuanjie , Zhu Jie , Liu Juan , Huang Mengjun , Wan Jin‐Xiang 
Published: February 2019

AbstractNonalcoholic fatty liver disease (NAFLD) poses serious threats to humans. Several studies have studied the biomarkers associated with NAFLD; however, the results vary because of the differences in the sequencing platform, sample selection, and filter conditions. This study aimed to explore the key microRNAs (miRNAs) of NAFLD by a systematic bioinformatics analysis. A total of 10 qualified NAFLD miRNA data sets were selected through a literature review. Signature miRNAs were identified by overlap comparison. The target genes of miRNAs were predicted by TargetScan software and functional enrichment, and transcription factor (TF) binding analysis of target genes was carried out by the database for annotation, visualization, and integrated discovery and Tfacts database, respectively. A total of three upregulated miRNAs and five downregulated miRNAs were identified in the NAFLD tissue. The target genes of upregulated miRNAs mainly enriched in the RNA polymerase II promoter transcriptional regulation, chromatin remodeling process, and O‐glycan synthesis, circadian rhythm, and endocytosis; the target genes of downregulated miRNAs mainly enriched in the transcriptional regulation of DNA as a template, negative regulation process of protein phosphorylation, and Fc epsilon RI signaling pathways, Ras signaling pathways and the interaction between cytokines and cytokines. Besides, 136 interactions were formed between 62 TFs and 45 target genes of upregulated miRNA, whereas 157 interactions were formed between 72 TFs and 45 target genes of downregulated miRNA. Both contained 102 TFs, and 32 TFs were present in both target genes. To summarize, we identified an eight‐miRNA set as a signature for NAFLD, which will benefit the clinical treatment of NAFLD.
Diagnostic thresholds and performance of noninvasive fibrosis scores are limited by age in patients with chronic hepatitis B
Authors: Wang Wentao , Zhao Xueqi , Li Guiping , Wang Lin , Chen Yizhi , Ma Ke , Chen Guang , Chen Tao , Han Meifang , Ning Qin , Zhao Xiping 
Published: February 2019

AbstractAimWe aimed at investigating the effects of age on the predictive performances of noninvasive fibrosis scores for significant fibrosis in patients with chronic hepatitis B (CHB).MethodsA total of 496 CHB patients who underwent liver biopsy were stratified into four age groups: ≤30, 31 to 40, 41 to 50, and ≥51 years. Receiver operating characteristic curves were used to evaluate the diagnostic performance of aspartate aminotransferase to platelet ratio index (APRI), fibrosis score‐4 (Fib‐4) and γ‐glutamyl transpeptidase to platelet ratio (GPR) in different age groups.ResultsThe extent of fibrosis significantly increased with age, and the percentage of significant fibrosis (≥F2) was 21.3%, 29.0%, 38.5%, and 46.1%, respectively. All three scores displayed a moderate accuracy to diagnose significant fibrosis in overall patients. However, for patients with age ≤30 years, APRI, Fib‐4, and GPR performed poorly with the AUROC of 0.567, 0.627 and 0.596, respectively. Furthermore, using the established cut‐off values—1.45 for Fib‐4, the sensitivity for significant fibrosis increased with age, from 14.8%, 38.1%, 74.5% to 97.87% in above age groups, respectively. To improve the diagnostic accuracy for significant fibrosis, the proposed low and high cut‐off points for Fib‐4 were 0.41 and 1.15 in ≤30 years, 0.8 and 1.59 in 31 to 40 years, 1.17 and 1.94 in 41 to 50 years, 1.76 and 3.10 in ≥ 51 years, respectively.ConclusionsAge may influence the diagnostic thresholds and performance of APRI, Fib‐4, and GPR for significant fibrosis in patients with CHB. In particular, these scores performed poorly for identifying significant fibrosis in younger patients (≤30 years).
A novel SIW based dual‐band power divider using double‐circular complementary split ring resonators
Authors: Duraisamy Tharani , Barik Rusan Kumar , Sholampettai Subramanian Karthikeyan , Kamatchi Selvajyothi 
Published: February 2019

AbstractThis article presents a novel design of substrate integrated waveguide (SIW) dual‐band power divider loaded with double‐circular complementary split‐ring resonators (CSRRs). The double‐circular CSRRs are etched on the top layer of the proposed structure to obtain the dual‐band characteristic. The proposed geometry provides a passband frequency below the cut‐off frequency of the SIW due to the electric dipole nature of the CSRRs. By changing the dimensions of the CSRRs, various passband characteristics are studied. To validate the design idea, a compact dual band power divider with equal power division operating at 8.4 and 11.7 GHz is designed, fabricated, and tested. A good steadiness is found between simulated and tested results. The proposed idea provides features of compact size, dual‐band operation, and good isolation. The size of the fabricated prototype excluding microstrip transition is 0.473λ
g × 0.284λ
g, where λ
g is the guided wave length at the center frequency of first band.
Turnover intention and job fit among nurses in Ghana: Does psychological climate matter?
Authors: Atitsogbui Julius , Amponsah‐Tawiah Kwesi 
Published: February 2019

AbstractAimThe study examined the relationship between turnover intention and job fit among Registered Nurses in Ghana. Further analysis was done to explore how nurses' psychological climate has an impact on the relationship between job fit and turnover intention.DesignThe study adopted the quantitative research approach and the cross‐sectional survey design in collecting data on the variables of interest.MethodsPurposive sampling was used to select the eight hospitals from both the public and the private sectors. In all, 322 Registered Nurses participated in the study and the data were analysed using simple and hierarchical multiple regression.ResultsThe results of the study showed no statistically significant relationship between nurses' turnover intention and job fit. However, psychological climate was found to fully mediate the relationship between turnover intention and job fit among the participants studied. Finally, the finding adds to theory by proposing a review and an extension of the Attraction‐Selection‐Attrition theory by Schneider (Personnel Psychology, 40, 1987, 437)
Experiences of specially trained personnel of group education for patients with type 2 diabetes—A lifeworld approach
Authors: Andersson Susanne , Berglund Mia , Vestman Caroline , Kjellsdotter Anna 
Published: February 2019

AbstractAimTo describe how the group education process for people with type 2 diabetes is experienced by diabetes nurses and dietitians who support the patients’ learning, in a primary care setting.DesignThe project took place at two primary care settings in the south of Sweden.MethodsData collected from focus‐group interviews and reflection notes were subjected to phenomenological analysis.ResultsThe specially trained personnel experienced that group education made it possible for the patients to learn through reflection concerning their own and others’ experiences. Furthermore, group education entailed increased knowledge for the trained personnel. When the patients were challenged to make changes in their lives with the illness, the personnel experienced that both patients and personnel supported each other. The study concludes that the trained personnel person‐centred approach, with help of the didactic model, get tools to support patients learning.
Building a framework for the evaluation of knowledge translation for the Canadian Network for Observational Drug Effect Studies
Authors: Sketris Ingrid S. , Carter Nancy , Traynor Robyn L. , Watts Dorian , Kelly Kim ,   On behalf of the following contributing members of the CNODES Knowledge Translation Team: Pierre Ernst, JM Gamble, Brenda Hemmelgarn, Colleen Metge, Michael Paterson, Robert Platt W. and Gary Teare
Published: February 2019

AbstractPurposeThe Canadian Network for Observational Drug Effect Studies (CNODES), a network of pharmacoepidemiologists and other researchers from seven provincial sites, provides evidence on the benefits and risks of drugs used by Canadians. The Knowledge Translation Team, one of CNODES' four main teams, evaluates the impact of its efforts using an iterative and emergent approach. This article shares key lessons from early evaluation phases, including identifying stakeholders and their evaluation needs, choosing evaluation theories and approaches, and developing evaluation questions, designs, and methods appropriate for the CNODES context.MethodsStakeholder analysis was conducted using documentary analysis to determine key contextual factors and research evidence needs of decision maker partners and other stakeholders. Selected theories and frameworks from the evaluation and knowledge translation literature informed decisions about evaluation design and implementation. A developmental approach to evaluation was deemed appropriate due to the innovative, complex, and ever‐changing context.ResultsA theory of change, logic model, and potential evaluation questions were developed, informed by the stakeholder analysis. Early indicators of program impact (citation metrics, alternative metrics) have been documented; efforts to collect data on additional indicators are ongoing.ConclusionA flexible, iterative, and emergent evaluation approach allows the Knowledge Translation Team to apply lessons learned from completed projects to ongoing research projects, adapt its approaches based on stakeholder needs, document successes, and be accountable to funders/stakeholders. This evaluation approach may be useful for other international pharmacoepidemiology research networks planning and implementing evaluations of similarly complex, multistakeholder initiatives that are subject to constant change.