bluuebunny/crossref_metadata_2025_split huggingface dataset:
From ‘Hard Rock Hallelujah’ to ‘Ukonhauta’ in Nokialand: a socionomic perspective on the mood shift in Finland's popular music from 2006 to 2009
Authors: Ketovuori Mikko , Lampert Matt 
Published: April 2018

AbstractSocial mood in Finland shifted from generally positive in the spring of 2006 to generally negative by the spring of 2009. We identify this change in mood via eight indicators, including the onset of a financial and macroeconomic crisis, a decline in measures of sentiment, a rise in radical politics and the demise of an iconic business unit of one of the country's most successful firms. From the standpoint of Prechter's socionomic theory we hypothesise that this change in social mood is also evident in a greater level of pessimism in the songs on the country's pop chart in 2009 relative to 2006. To test this hypothesis, we introduce and validate a tool to measure optimism and pessimism in popular music. We apply this tool to a random sample of songs from the Finnish pop chart from 2006 and a comparable sample from 2009. Indeed, we find that the sample from 2009 in the aggregate is substantially and significantly more pessimistic than the sample from 2006. The study serves to enrich our understanding of what makes pop songs popular and how popular music is linked psychologically to broader popular culture and other domains of social expression through a shared social mood.
Future Change to Tide‐Influenced Deltas
Authors: Nienhuis Jaap H. , Hoitink A. J. F. (Ton) , Törnqvist Torbjörn E. 
Published: April 2018

AbstractTides tend to widen deltaic channels and shape delta morphology. Here we present a predictive approach to assess a priori the effect of fluvial discharge and tides on deltaic channels. We show that downstream channel widening can be quantified by the ratio of the tide‐driven discharge and the fluvial discharge, along with a second metric representing flow velocities. A test of our new theory on a selection of 72 deltas globally shows good correspondence to a wide range of environments, including wave‐dominated deltas, river‐dominated deltas, and alluvial estuaries. By quantitatively relating tides and fluvial discharge to delta morphology, we offer a first‐order prediction of deltaic change that may be expected from altered delta hydrology. For example, we expect that reduced fluvial discharge in response to dam construction will lead to increased tidal intrusion followed by enhanced tide‐driven sediment import into deltas, with implications for navigation and other human needs.
ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA
Authors: Chen Yen-Chun , Tsai Chia-Ling , Wei Yau-Huei , Wu Yu-Ting , Hsu Wei-Ting , Lin Hung-Ching , Hsu Yi-Chao 
Published: April 2018

AbstractDegeneration or loss of inner ear hair cells (HCs) is irreversible and results in sensorineural hearing loss (SHL). Human-induced pluripotent stem cells (hiPSCs) have been employed in disease modelling and cell therapy. Here, we propose a transcription factor (TF)-driven approach using ATOH1 and regulatory factor of x-box (RFX) genes to generate HC-like cells from hiPSCs. Our results suggest that ATOH1/RFX1/RFX3 could significantly increase the differentiation capacity of iPSCs into MYO7AmCherry-positive cells, upregulate the mRNA expression levels of HC-related genes and promote the differentiation of HCs with more mature stereociliary bundles. To model the molecular and stereociliary structural changes involved in HC dysfunction in SHL, we further used ATOH1/RFX1/RFX3 to differentiate HC-like cells from the iPSCs from patients with myoclonus epilepsy associated with ragged-red fibres (MERRF) syndrome, which is caused by A8344G mutation of mitochondrial DNA (mtDNA), and characterised by myoclonus epilepsy, ataxia and SHL. Compared with isogenic iPSCs, MERRF-iPSCs possessed ~42–44% mtDNA with A8344G mutation and exhibited significantly elevated reactive oxygen species (ROS) production and CAT gene expression. Furthermore, MERRF-iPSC-differentiated HC-like cells exhibited significantly elevated ROS levels and MnSOD and CAT gene expression. These MERRF-HCs that had more single cilia with a shorter length could be observed only by using a non-TF method, but those with fewer stereociliary bundle-like protrusions than isogenic iPSCs-differentiated-HC-like cells could be further observed using ATOH1/RFX1/RFX3 TFs. We further analysed and compared the whole transcriptome of M1ctrl-HCs and M1-HCs after treatment with ATOH1 or ATOH1/RFX1/RFX3. We revealed that the HC-related gene transcripts in M1ctrl-iPSCs had a significantly higher tendency to be activated by ATOH1/RFX1/RFX3 than M1-iPSCs. The ATOH1/RFX1/RFX3 TF-driven approach for the differentiation of HC-like cells from iPSCs is an efficient and promising strategy for the disease modelling of SHL and can be employed in future therapeutic strategies to treat SHL patients.
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection
Authors: Zhao Juan , Dang Xindi , Zhang Peixin , Nguyen Lam Nhat , Cao Dechao , Wang Lin , Wu Xiaoyuan , Morrison Zheng D , Zhang Ying , Jia Zhansheng , Xie Qian , Wang Ling , Ning Shunbin , EL Gazzar Mohamed , Moorman Jonathan P , Yao Zhi Q 
Published: April 2018

AbstractT cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects with hepatitis C virus (HCV) infection. We found that naive CD4 T cells in chronically HCV-infected individuals (HCV T cells) were significantly reduced compared with age-matched healthy subjects. In addition, HCV T cells were prone to apoptosis and DNA damage, as evidenced by increased 8-oxoguanine expression and γH2AX/53BP1-formed DNA damage foci—hallmarks of DNA damage responses. Mechanistically, the activation of DNA repair enzyme ataxia telangiectasia mutated (ATM) was dampened in HCV T cells. ATM activation was also diminished in healthy T cells exposed to ATM inhibitor or to HCV (core protein) that inhibits the phosphoinositide 3 kinase pathway, mimicking the biological effects in HCV T cells. Importantly, ectopic expression of ATM was sufficient to repair the DNA damage, survival deficit, and cell dysfunctions in HCV T cells. Our results demonstrate that insufficient DNA repair enzyme ATM leads to increased DNA damage and renders HCV T cells prone to apoptotic death, which contribute to the loss of naive T cells in HCV infection. Our study reveals a novel mechanism for T-cell dysregulation and viral persistence, providing a new strategy to improve immunotherapy and vaccine responses against human viral diseases.
Stripe order from the perspective of the Hubbard model
Authors: Huang Edwin W. , Mendl Christian B. , Jiang Hong-Chen , Moritz Brian , Devereaux Thomas P. 
Published: April 2018

AbstractA microscopic understanding of the strongly correlated physics of the cuprates must account for the translational and rotational symmetry breaking that is present across all cuprate families, commonly in the form of stripes. Here we investigate emergence of stripes in the Hubbard model, a minimal model believed to be relevant to the cuprate superconductors, using determinant quantum Monte Carlo (DQMC) simulations at finite temperatures and density matrix renormalization group (DMRG) ground state calculations. By varying temperature, doping, and model parameters, we characterize the extent of stripes throughout the phase diagram of the Hubbard model. Our results show that including the often neglected next-nearest-neighbor hopping leads to the absence of spin incommensurability upon electron-doping and nearly half-filled stripes upon hole-doping. The similarities of these findings to experimental results on both electron and hole-doped cuprate families support a unified description across a large portion of the cuprate phase diagram.
Chitosan-titanium oxide fibers supported zero-valent nanoparticles: Highly efficient and easily retrievable catalyst for the removal of organic pollutants
Authors: Ali Fayaz , Khan Sher Bahadar , Kamal Tahseen , Alamry Khalid A. , Asiri Abdullah M. 
Published: April 2018

AbstractDifferent chitosan-titanium oxide (CS-TiO2-x, with x = TiO2 loadings of 1, 5, 10,15 and 20 wt%) nanocomposite fibers were prepared and kept separately in each salt solution of CuSO4, CoNO3, AgNO3 and NiSO4 to adsorb Cu2+, Co2+, Ag+, and Ni+ ions, respectively. The metal ions loaded onto CS-TiO2 fibers were reduced to their respective zero-valent metal nanoparticles (ZV-MNPs) like Cu0, Co0, Ag0 and Ni0 by treating with NaBH4. The CS-TiO2 fibers templated with various ZV-MNPs were characterized and investigated for their catalytic efficiency. Among all prepared ZV-MNPs, Cu0 nanoparticles templated on CS-TiO2-15 fibers exhibited high catalytic efficiency for the reduction of dyes (methyl orange (MO), congo red (CR), methylene blue (MB) and acridine orange (AO)) and nitrophenols (4-nitrohphenol (4-NP), 2-nitrophenol (2-NP), 3-nitrophenol (3-NP) and 2,6-dinitrophenol (2,6-DNP)). Besides the good catalytic activities of Cu/CS-TiO2-15 fibers, it could be easily recovered by simply pulling the fiber from the reaction medium.
Reconstructing the Neanderthal brain using computational anatomy
Authors: Kochiyama Takanori , Ogihara Naomichi , Tanabe Hiroki C. , Kondo Osamu , Amano Hideki , Hasegawa Kunihiro , Suzuki Hiromasa , Ponce de León Marcia S. , Zollikofer Christoph P. E. , Bastir Markus , Stringer Chris , Sadato Norihiro , Akazawa Takeru 
Published: April 2018

AbstractThe present study attempted to reconstruct 3D brain shape of Neanderthals and early Homo sapiens based on computational neuroanatomy. We found that early Homo sapiens had relatively larger cerebellar hemispheres but a smaller occipital region in the cerebrum than Neanderthals long before the time that Neanderthals disappeared. Further, using behavioural and structural imaging data of living humans, the abilities such as cognitive flexibility, attention, the language processing, episodic and working memory capacity were positively correlated with size-adjusted cerebellar volume. As the cerebellar hemispheres are structured as a large array of uniform neural modules, a larger cerebellum may possess a larger capacity for cognitive information processing. Such a neuroanatomical difference in the cerebellum may have caused important differences in cognitive and social abilities between the two species and might have contributed to the replacement of Neanderthals by early Homo sapiens.
Population Structure Promotes the Evolution of Intuitive Cooperation and Inhibits Deliberation
Authors: Mosleh Mohsen , Rand David G. 
Published: April 2018

AbstractSpatial structure is one of the most studied mechanisms in evolutionary game theory. Here, we explore the consequences of spatial structure for a question which has received considerable empirical and theoretical attention in recent years, but has not yet been studied from a network perspective: whether cooperation relies on intuitive predispositions or deliberative self-control. We examine this question using a model which integrates the “dual-process” framework from cognitive science with evolutionary game theory, and considers the evolution of agents who are embedded within a social network and only interact with their neighbors. In line with past work in well-mixed populations, we find that selection favors either the intuitive defector strategy which never deliberates, or the dual-process cooperator strategy which intuitively cooperates but uses deliberation to switch to defection when doing so is payoff-maximizing. We find that sparser networks (i.e., smaller average degree) facilitate the success of dual-process cooperators over intuitive defectors, while also reducing the level of deliberation that dual-process cooperators engage in; and that these results generalize across different kinds of networks. These observations demonstrate the important role that spatial structure can have not just on the evolution of cooperation, but on the co-evolution of cooperation and cognition.
Analysis of microRNA reveals cleistogamous and chasmogamous floret divergence in dimorphic plant
Authors: Wu Fan , Zhang Daiyu , Muvunyi Blaise Pascal , Yan Qi , Zhang Yufei , Yan Zhuanzhuan , Cao Mingshu , Wang Yanrong , Zhang Jiyu 
Published: April 2018

AbstractCleistogenes songorica, a grass species that exhibits two spatially different type of inflorescence, chastogamy (CH), flowers localized at the top, and cleistogamy (CL) flowers embedded in leaf sheath. This study aimed at dissecting reasons underlying these distinct floral development patterns at morphological and microRNA level. Phenotyping for CH and CL was conducted and four small RNA libraries were constructed from the CH and CL flowers for high-throughput sequencing to identify the differentiated miRNAs. As results, spikelet, stigma, anther, lemma and lodicule length of CH flowers were found larger than that of CL, and so was seed setting. Also, 17 flower-related differential expression miRNAs were identified which were associated with floral organ development and morphogenesis, and the flower development. Further results showed that miR159a.1-CL3996.Contig2 pair was related to anther development, miR156a-5p-CL1954.Contig2 was linked to response to high light intensity, miR408-3p/miR408d-Unigene429 was related to pollination and Unigene429 positively regulated flower development. To our knowledge, this is the first study on differential miRNA accumulation between CH and CL flowers and our study serves as a foundation to the future elucidation of regulatory mechanisms of miRNAs in the divergent development of CL and CH flowers in a single plant.
Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation
Authors: Ngo Thai Bich Van , Hongu Tsunaki , Miura Yuki , Katagiri Naohiro , Ohbayashi Norihiko , Yamashita-Kanemaru Yumi , Shibuya Akira , Funakoshi Yuji , Kanaho Yasunori 
Published: April 2018

AbstractTwo major phospholipase D (PLD) isozymes in mammals, PLD1 and PLD2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. Although their roles in cancer cells have been well studied, their functions in tumor microenvironment have not yet been clarified. Here, we demonstrate that PLD2 in cytotoxic CD8+T cells plays a crucial role in anti-tumor immunity by regulating their cell proliferation. We found that growth of tumors formed by subcutaneously transplanted cancer cells is enhanced inPld2-knockout mice. Interestingly, this phenotype was found to be at least in part attributable to the ablation ofPld2from bone marrow cells. The number of CD8+T cells, which induce cancer cell death, significantly decreased in the tumor produced inPld2-knockout mice. In addition, CD3/CD28-stimulated proliferation of primary cultured splenic CD8+T cells is markedly suppressed byPld2ablation. Finally, CD3/CD28-dependent activation of Erk1/2 and Ras is inhibited inPld2-deleted CD8+T cells. Collectively, these results indicate that PLD2 in CD8+T cells plays a key role in their proliferation through activation of the Ras/Erk signaling pathway, thereby regulating anti-tumor immunity.
Prognostic significances of overexpression MYC and/or BCL2 in R-CHOP-treated diffuse large B-cell lymphoma: A Systematic review and meta-analysis
Authors: Li Lu , Li Yanyan , Que Ximei , Gao Xue , Gao Qian , Yu Mingxing , Ma Kaili , Xi Yanfeng , Wang Tong 
Published: April 2018

AbstractNumerous studies have investigated the prognostic values of MYC and/or BCL2 protein overexpression in diffuse large B-cell lymphoma (DLBCL). However, the results still demonstrate discrepancies among different studies. We aimed to do a systematic review and meta-analysis on the relationships between overexpression MYC and/or BCL2 and DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). This study followed the guidelines of PRISMA and Cochrane handbook. The hazard ratios (HRs) for overall survival (OS) were pooled to estimate the main effect size. Twenty studies recruited a total of 5576 patients were available for this meta-analysis. The results showed that MYC (HR = 1.96, 95%CI (confidence interval) = 1.69–2.27)without heterogeneity(I2 = 17.2%, P = 0.280), BCL2 (HR = 1.65, 95%CI = 1.43–1.89, I2 = 20.7%, P = 0.234) protein overexpression, and co-overexpression (HR = 2.58, 95%CI = 2.19–3.04, I2 = 17.2%, P = 0.275) had a poor prognosis in R-CHOP treated DLBCL patients, respectively. The current analysis indicated that MYC and/or BCL2 protein overexpression, and particularly co-overexpression was related to short overall survival in R-CHOP treated DLBCL patients, showing that application of the two new biomarkers can help to better stratify DLBCL patients and guide targeted treatment.
STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells
Authors: Burnell Stephanie E. A. , Spencer-Harty Samantha , Howarth Suzie , Bodger Owen , Kynaston Howard , Morgan Claire , Doak Shareen H. 
Published: April 2018

AbstractSix-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate if its knockdown resulted in reduced invasive potential of prostate cancer cells. PC3 and LNCaP cells were transfected with STEAP2 siRNA and proliferation, migration, invasion and gene expression analyses were performed. STEAP2 immunohistochemistry was applied to assess the protein expression and localisation according to Gleason score in 164 prostate cancer patients. Invasion significantly decreased in both cell lines following STEAP2 knockdown. PC3 proliferation and migration capacity significantly reduced, while LNCaP cell morphology and growth characteristics were altered. Additionally, STEAP2 downstream targets associated with driving invasion were identified as MMP3, MMP10, MMP13, FGFR4, IL1β, KiSS1 and SERPINE1 in PC3 cells and, MMP7 in LNCaP cells, with CD82 altered in both. In patient tissues, STEAP2 expression was significantly increased in prostate cancer samples and this significantly correlated with Gleason score. These data demonstrate that STEAP2 drives aggressive prostate cancer traits by promoting proliferation, migration and invasion and significantly influencing the transcriptional profile of ten genes underlying the metastatic cascade.
Enzyme-catalyzed Ag Growth on Au Nanoparticle-assembled Structure for Highly Sensitive Colorimetric Immunoassay
Authors: Pham Xuan-Hung , Hahm Eunil , Kim Tae Han , Kim Hyung-Mo , Lee Sang Hun , Lee Yoon-Sik , Jeong Dae Hong , Jun Bong-Hyun 
Published: April 2018

AbstractWe have developed a sensitive colorimetric immunoassay with broad dynamic range using enzyme-catalyzed Ag growth on gold nanoparticle (NP)-assembled silica (SiO2@Au@Ag). To reduce Ag+ion content and promote Ag growth on the assembled Au NPs, alkaline phosphatase (AP)-based enzymatic amplification was incorporated, which considerably increased the colorimetric read-out. As a model study, sandwich enzyme-linked immunosorbent assay (ELISA) was used to quantify target IgG. The immune complexes capture the Ab-IgG-AP-labeled detection Ab and trigger the enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid to ascorbic acid in the presence of the target IgG. Ascorbic acid reduced Ag+to Ag, which formed Ag shells on the surface of SiO2@Au and enhanced the absorbance of the SiO2@Au@Ag solution. Plasmonic immunoassay showed a significant linear relationship between absorbance and the logarithm of IgG concentration in the range of ca. 7 × 10−13 M to 7 × 10−11 M. The detection limit was at 1.4 × 10−13 M, which is several hundred folds higher than that of any conventional colorimetric immunoassay. Thus, our novel approach of signal-amplification can be used for highly sensitivein vitrodiagnostics and detection of target proteins with the naked eye without using any sophisticated instrument.
Ecology determines how low antibiotic concentration impacts community composition and horizontal transfer of resistance genes
Authors: Cairns Johannes , Ruokolainen Lasse , Hultman Jenni , Tamminen Manu , Virta Marko , Hiltunen Teppo 
Published: April 2018

AbstractLow concentrations of antibiotics have numerous effects on bacteria. However, it is unknown whether ecological factors such as trophic interactions and spatial structuring influence the effects of low concentrations of antibiotics on multispecies microbial communities. Here, we address this question by investigating the effects of low antibiotic concentration on community composition and horizontal transfer of an antibiotic resistance plasmid in a 62-strain bacterial community in response to manipulation of the spatial environment and presence of predation. The strong effects of antibiotic treatment on community composition depend on the presence of predation and spatial structuring that have strong community effects on their own. Overall, we find plasmid transfer to diverse recipient taxa. Plasmid transfer is likely to occur to abundant strains, occurs to a higher number of strains in the presence of antibiotic, and also occurs to low-abundance strains in the presence of spatial structures. These results fill knowledge gaps concerning the effects of low antibiotic concentrations in complex ecological settings.
Association of FcεRIβ polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case–control studies
Authors: Guo Huanhuan , Peng Tao , Luo Ping , Li Huabin , Huang Shuo , Li Shuang , Zhao Weidong , Zhou Xuhong 
Published: April 2018

Purpose: Accumulating evidence has shown that allergic diseases are caused by a complex interaction of genetic and environmental factors, some single nucleotide polymorphisms (SNPs) existing in high-affinity IgE receptor β chain (FcεRIβ) are potential risk factors for allergic diseases. However, the results have been inconsistent and inconclusive due to the limited statistical power in individual study. Thus, we conducted a meta-analysis to systematically evaluate the association between FcεRIβ SNPs and allergic diseases risk.
Methods: Eligible studies were collected from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases. Pooled odd ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the strength of the relationships between five polymorphisms (E237G, -109 C/T, RsaI_in2, RsaI_ex7, and I181L) and the risk of allergic diseases by using five genetic models. In addition, the stability of our analysis was evaluated by publication bias, sensitivity, and heterogeneity analysis.
Results: Overall, a total of 29 case–control studies were included in this meta-analysis. We found that E237G (B vs. A: OR = 1.28, 95% CI = 1.06–1.53, P&lt;0.001, I2 = 63.1%) and -109 C/T (BB vs. AA + AB: OR = 1.58, 95%CI = 1.26–1.98, P&lt;0.001, I2 = 66.4%) were risk factors for allergic diseases.
Conclusion: Our meta-analysis suggests that polymorphisms in FcεRIβ may be associated with the development of allergic diseases.
Monitoring of dispersed smoke-plume layers by determining locations of the data-point clusters
Authors: Kovalev Vladimir , Wold Cyle , Petkov Alexander , Min Hao Wei 
Published: April 2018

A modified data-processing technique of the signals recorded by zenith-directed lidar, which operates in smoke-polluted atmosphere, is discussed. The technique is based on simple transformations of the lidar backscatter signal and the determination of the spatial location of the data point clusters.
The technique allows more reliable detection of the location of dispersed smoke layering. Examples of typical results obtained with lidar in a smokepolluted atmosphere are presented.