bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical profile of ACS patients and their outcome at tertiary centre in north-eastern Uttar Pradesh, India
Authors: Sarkari M. , Singh Ajeet P. 
Published: March 2018

Background: Coronary artery disease (CAD) is a major cause of death in India. This study determined the characteristics, treatment and outcomes of acute coronary syndrome (ACS) at tertiary centre in north eastern Uttar Pradesh in India.Methods: We carried out observational study with 60-days follow-up of 80 ACS patients. Data are collected on different variables including Blood pressure, pulserate, BNP, TROP I, CKMB, patient’s demography, risk factors, laboratory values at admission and repeated as and when required. Results: T In our study most common presentation was chest pain, majority of patients presented after 12 hour of onset of symptoms, elevation of TROP I was higher in STEMI than NSTEMI, most common complication in NSTEMI was recurrent angina and in STEMI patients was heart failure, total 15 patients expired during study 11 during hospitalization and 4 patients within 60days of follow up, thrombolysed patients has less chances of regional wall motion abnormality.Conclusions: In our study elevation of TROP I was more in STEMI and there was less chances of RWMA in thrombolysed patients.
Chemical Castration Using Iron (III) Chloride Hexahydrate (KEBIRI KIMIAWI MENGGUNAKAN FERIKLORIDA HEKSAHIDRAT)
Authors: Ulum Mokhamad Fakhrul , Paramitha Devi , Sariningrum Arlita , Maharani Anizza Dyah Kartika , Tumbelaka Ligaya ITA , Noviana Deni 
Published: March 2018

Chemical castration is a method that can be applied easily without any surgical intervention in animals. This study utilized iron (III) chloride hexahydrate (FeCl3.6H2O) as a new material for chemical castration in mice. Twenty seven adult male mice were divided into five groups: FeCl3 20% (n = 6), FeCl3 10% (n = 6), FeCl3 5.0% (n = 6), FeCl3 2.5% (n = 6), and control NaCl 0.9% (n = 3). A 0.2 mL of NaCl 0.9% or FeCl3 in various concentrations was injected intra-testicularly on each testis of the mice. Post-castration survival rate with LD50 values was obtained at the concentrations between 2.5-5.0% of FeCl3 groups, and 100% mice survived in the control group. The size of testis and concentration of spermatozoa decreased, in contrast with the increased concentration of FeCl3 solution used seven days post-injection compared to the control group.
ABSTRAK
Kebiri/kastrasi kimiawi secara injeksi intra-testis merupakan metode pengebiriam yang dapat dilakukan dengan mudah tanpa prosedur bedah pada hewan. Penelitian ini memanfaatkan larutan besi (ferri/III) klorida (FeCl3) sebagai bahan baru untuk tindakan kebiri kimiawi pada mencit. Mencit jantan dewasa umur lima bulan sebanyak 27 ekor dibagi dalam lima kelompok yaitu FeCl3 20% (n=6), FeCl3 10% (n=6), FeCl3 5,0% (n=6), FeCl3 2,5% (n=6) dan kontrol NaCl 0,9% (n=3). Larutan FeCl3 sebanyak 0,2 mL diinjeksikan secara intra-testikel pada setiap organ testis. Daya hidup pascakebiri injeksi nilai LD 50 diperoleh pada kelompok FeCl3 konsentrasi di antara 2,5-5,0 % dan kelompok kontrol 100 % hidup. Organ testis dalam skrotum mengalami pengecilan ukuran dan konsentrasi spermatozoa mengalami penurunan seiring dengan peningkatan konsentrasi larutan FeCl3 yang digunakan setelah tujuh hari pasca injeksi dibandingkan dengan kontrol.
Dissolved Organic Carbon in Leachate after Application of Granular and Liquid N–P–K Fertilizers to a Sugarcane Soil
Authors: Pittaway P. A. , Melland A. R. , Antille D. L. , Marchuk S. 
Published: March 2018

The progressive decline of soil organic matter (SOM) threatens the sustainability of arable cropping worldwide. Residue removal and burning, destruction of protected microsites, and the acceleration of microbial decomposition are key factors. Desorption of SOM by ammonia‐based fertilizers from organomineral complexes in soil may also play a role. A urea‐ and molasses‐based liquid fertilizer formulation and a urea‐based granular formulation were applied at recommended and district practice rates, respectively, to soil leaching columns, with unfertilized columns used as controls. The chemistry of leachate collected from the columns, filled with two sandy soils differing in recent cropping history, was monitored over eight successive wet–dry drainage events. The pH, electrical conductivity, and concentration and species of N in leachate was compared with the concentration and aromaticity of dissolved organic C (DOC) to indicate if salt solutions derived from the two fertilizers extracted SOM from clay mineral sites. Cation exchange capacity and exchangeable cations in the soil were monitored at the start and end of the trial. Fertilizer application increased DOC in leachate up to 40 times above the control, but reduced aromaticity (specific ultraviolet light absorbance at 253.7 nm). Dissolved organic C was linearly proportional to leachate NH4–N concentration. Exchangeable Ca and Mg in soil from fertilized columns at the end of both trials were significantly lower than in unfertilized soil, indicating that ammonium salt solutions derived from the fertilizers extracted cations and variably charged organic matter from soil mineral exchange sites. Desorption of organic matter and divalent cations from organomineral sites by ammonia‐based fertilizers may be implicated in soil acidification.Core Ideas
Ammonium N displaces DOC from organomineral complexes.
Fertilizers formulated with molasses stimulate N immobilization.
Displaced DOM is less aromatic than unfertilized DOM.
Displacement of DOM contributes to acidification.
DOM leaching with nitrate may increase N2O emissions.
Lysimeters in Vadose Zone Research
Authors: Pütz Thomas , Fank Johann , Flury Markus 
Published: March 2018

Core Ideas
Lysimeters bridge the gap between laboratory and field experiments.
Lysimeters allow the measurement of a complete water balance.
Lysimeters provide a complete mass balance for a representative ecosystem segment.
Lysimeters are methodological experimental tools to study the water and matter fluxes in the vadose zone, as well as the environmental fate of chemicals. Lysimeters are available in various types. The most sophisticated lysimeters are filled monolithically, are equipped with a pressure‐controlled lower boundary, and are weighable, allowing the measurement of hydraulic fluxes, i.e., rainfall, drainage, evapotranspiration, dew, and hoar frost with high precision. This special section of Vadose Zone Journal reports on current lysimeter research.
Assessment of drinking water suitability in low income rural areas: a case study in Sixaola, Costa Rica
Authors: Mena-Rivera Leonardo , Quirós-Vega José 
Published: March 2018

Abstract
Vegas-Las Palmas is a rural settlement located in the southern Caribbean region of Costa Rica on the border with Panama. Its population does not have access to potable water, and inhabitants depend on water from wells at the water table level to meet their needs. These wells lack basic infrastructure to protect this water from contamination. In this study, water quality was evaluated at 12 wells from 2014 to 2016 (n = 72). The results revealed high concentrations of faecal coliforms and Escherichia coli with maximum values of 4.6 × 104 MPN/100 mL and 1.1 × 104 MPN/100 mL, respectively. In addition, maximum values of pH, conductivity, turbidity, Ca, Mg, K, Fe, Mn, Cd and Pb were found to be outside the standard limits (nationally and internationally) for potable water. Possible sources of water contamination are associated with the geomorphological characteristics of the area, as well as with hydrometeorological and anthropogenic factors such as the lack of sewerage, the presence of latrines, animals near the wells and the use of agrochemicals. The water quality was heterogeneous among wells, and all of them were found to have conditions that caused water to be unfit for human consumption.
Ligand and Structure-based Modeling of Passive Diffusion through the Blood-Brain Barrier
Authors: Vilar Santiago , Sobarzo-Sanchez Eduardo , Santana Lourdes , Uriarte Eugenio 
Published: March 2018

Background:
Blood-brain barrier transport is an important process to be considered in drug
candidates. The blood-brain barrier protects the brain from toxicological agents and, therefore, also
establishes a restrictive mechanism for the delivery of drugs into the brain. Although there are different
and complex mechanisms implicated in drug transport, in this review we focused on the prediction of
passive diffusion through the blood-brain barrier.

Methods:
We elaborated on ligand-based and structure-based models that have been described to predict
the blood-brain barrier permeability.

Results:
Multiple 2D and 3D QSPR/QSAR models and integrative approaches have been published to
establish quantitative and qualitative relationships with the blood-brain barrier permeability. We explained
different types of descriptors that correlate with passive diffusion along with data analysis
methods. Moreover, we discussed the applicability of other types of molecular structure-based simulations,
such as molecular dynamics, and their implications in the prediction of passive diffusion. Challenges
and limitations of experimental measurements of permeability and in silico predictive methods
were also described.

Conclusion:
Improvements in the prediction of blood-brain barrier permeability from different types
of in silico models are crucial to optimize the process of Central Nervous System drug discovery and
development.
Functionalized Multi Walled Carbon Nanotubes-Reinforced Hollow Fiber Solid/Liquid Phase Microextraction and HPLC-DAD for Determination of Phenazopyridine in Urine
Authors: Al-Hashimi Nabil N. , Awwad Anas I. , Al-Hashimi Aqeel N. , Mansi Iman A. , Shahin Rand O. , Hamed Saja H. 
Published: March 2018

Introduction:A sensitive analytical method based on functionalized multi walled carbon nanotubes reinforced hollow fiber solid/liquid phase microextraction (F-MWCNTs-HF-SLPME) forwarded with HPLC-DAD for analyzing phenazopyridine from urine is presented.Materials and Methods:The extraction of phenazopyridine is performed using specially designed FMWCNTs- HF-SLPME device constructed as follows: the functionalized multi walled carbon nanotubes (F-MWCNTs) were immobilized into the pores of 2.5 cm hollow fiber micro-tube using capillary forces and ultrasonication, then, the lumen of the micro-tube was filled with 1-octanol with two ends sealed. Subsequently, the device was placed into 10-mL of urine sample containing the analyte with agitation. After ending extraction, the device was removed, rinsed, sonicated in 250 µL of organic solvent and analyzed directly by the separation system.Results and Conclusion:Different parameters affecting the performance of the developed method were optimized. The method showed good linearity with (R2) 0.999 and good repeatability with (RSDs) from 3.7 to 0.9% at analyte concentration ranged from 0.01 to 10 µg L-1 of spiked urine samples. The limit of detection/ quantitation, LODs/LOQs was 0.02/0.09 µg L-1. In comparison with reference methods, the developed method is considered as a promising microextraction technique for determination of trace phenazopyridine in human urine using a common HPLC without further cleanup procedures.
Teachers’ Effectiveness in Developing Constructive Learning in Civic Education
Authors: Dewi Dinie Anggraeni , Nuraeni Nani 
Published: March 2018

The background of this study is the importance of teachers’ pedagogical competence in developing their professional duties by developing the learning activities as many as it could to achieve the learning outcomes from the learners. This is only possible if the teachers involve the thinking construct of learners in the learning process effectively by considering the available time aspect to gain optimal achievements in learning outcomes. This paper is the result of an in-depth research of the civic teachers who effectively develop constructive learning and show positive results in the learning quality of their students in the primary education level of junior high school. In order to obtain the meaning of the research objective, the researcher employs an integrated qualitative and quantitative approaches. The result of the study found that teachers’ effectiveness in developing constructive learning is showed by an attempt to create a productive learning atmosphere in the process of learning and to in-volve various learning interaction patterns to explore learners’ thinking skill in a high level.
Keywords: teachers’ effectiveness, constructive learning, quality of learning outcomes
ABSTRAK
Penelitian ini dilatarbelakangi dengan pentingnya kompetensi pedagogik guru dalam mengembangkan tugas profesinya yakni mengembangkan pembelajaran untuk sebesar-besarnya mencapai hasil belajar peserta didik. Hal ini hanya mungkin dapat dicapai apabila guru efektif melibatkan konstruk berfikir peserta didik dalam proses pembelajarannya, yakni mempertimbangkan aspek waktu yang tersedia untuk memperoleh capaian hasil belajar optimal. Tulisan ini merupakan hasil penelitian mendalam terhadap guru Pendidikan Pancasila dan Kewarganegaraan yang efektif mengembangkan pembelajaran konstruktif dan menunjukkan hasil positif terhadap kualitas belajar peserta didiknya pada jenjang pendidikan dasar Sekolah Menengah Pertama. Untuk memperoleh makna tujuan penelitian, digunakan pendekatan kualitatif dan kuantitatif secara terpadu. Hasil penelitian efektifitas guru dalam mengembangkan pembelajaran konstruktif ditunjukkan dengan upayanya untuk menciptakan suasana yang produktif dalam proses belajar dan melibatkan pola interaksi pembelajaran variatif untuk menggali keterampilan berfikir peserta didik pada tingkat tinggi.
Kata kunci: efektifitas guru, pembelajaran konstruktif, kualitas hasil belajar
Rabies surveillance in the United States during 2016
Authors: Ma Xiaoyue , Monroe Benjamin P. , Cleaton Julie M. , Orciari Lillian A. , Yager Pamela , Li Yu , Kirby Jordona D. , Blanton Jesse D. , Petersen Brett W. , Wallace Ryan M. 
Published: March 2018

Abstract
OBJECTIVE To describe rabies and rabies-related events occurring during 2016 in the United States.
DESIGN Observational study based on passive surveillance data.
ANIMALS All animals submitted for rabies testing in the United States during 2016.
PROCEDURES State and territorial public health programs provided data on animals submitted for rabies testing in 2016. Data were analyzed temporally and geographically to assess trends in domestic and sylvatic animal rabies cases.
RESULTS During 2016, 50 states and Puerto Rico reported 4,910 rabid animals to the CDC, representing a 10.9% decrease from the 5,508 rabid animals reported in 2015. Of the 4,910 cases of animal rabies, 4,487 (91.4%) involved wildlife. Relative contributions by the major animal groups were as follows: 1,646 (33.5%) bats, 1,403 (28.6%) raccoons, 1,031 (21.0%) skunks, 313 (6.4%) foxes, 257 (5.2%) cats, 70 (1.4%) cattle, and 58 (1.2%) dogs. There was a 4.6% decrease in the number of samples submitted for testing in 2016, compared with the number submitted in 2015. No human rabies deaths were reported in 2016.
CONCLUSIONS AND CLINICAL RELEVANCE Laboratory testing of animals suspected to be rabid remains a critical public health function and continues to be a cost-effective method to directly influence human rabies postexposure prophylaxis recommendations.
Comparison of thoracic duct ligation plus subphrenic pericardiectomy with or without cisterna chyli ablation for treatment of idiopathic chylothorax in cats
Authors: Stockdale Stephen L. , Gazzola Krista M. , Strouse Jennifer B. , Stanley Bryden J. , Hauptman Joe G. , Mison Michael B. 
Published: March 2018

Abstract
OBJECTIVE To compare duration of surgery, recurrence rate, and survival time between cats with idiopathic chylothorax treated with thoracic duct ligation (TDL) plus subphrenic pericardiectomy (SPC) and those treated with TDL, SPC, and cisterna chyli ablation (CCA).
DESIGN Retrospective case series with nested cohort study.
ANIMALS 22 client-owned cats surgically treated for idiopathic chylothorax from 2009 through 2014.
PROCEDURES Patient and surgery data were collected from the medical records. Recurrence of chylothorax and survival time were assessed by medical record review and client interview. Comparisons were made between cats treated with TDL plus SPC (TDL-SPC group) and those treated with TDL, SPC, and CCA (TDL-SPC-CCA group).
RESULTS 15 cats were treated with TDL plus SPC, and 7 were treated with TDL, SPC, and CCA. Median duration of surgery was significantly briefer for the TDL-SPC group (80 minutes; range, 55 to 175 minutes) than for the TDL-SPC-CCA group (125 minutes; range, 105 to 205 minutes). Five cats (2 in the TDL-SPC group and 3 in the TDL-SPC-CCA group) had persistent pleural effusion 4 weeks after surgery. Chylothorax recurred in 2 cats (1/group). Median survival time in the TDL-SPC group was 774 days (range, 3 to 2,844 days) and in the TDL-SPC-CCA group was 380 days (range, 11 to 815 days); these values did not differ significantly.
CONCLUSIONS AND CLINICAL RELEVANCE Addition of CCA to the surgical treatment approach for cats with idiopathic chylothorax was associated with a significantly longer duration of surgery with no better outcome than achieved with TDL plus SPC alone.
Modelling of Graph Databases
Authors: Pokorny Jaroslav 
Published: March 2018

Comparing graph databases with traditional,e.g., relational databases, some important database features are often missing there. Particularly, a graph database schema including integrity constraints is mostly not explicitly defined, also a conceptual modelling is not used. It is hard to check a consistency of the graph database, because almost no integrity constraints are defined or only their very simple representatives can be specified. In the paper, we discuss these issues and present current possibilities and challenges in graph database modelling. We focus also on integrity constraints modelling and propose functional dependencies between entity types, which reminds modelling functional dependencies known from relational databases. We show a number of examples of often cited GDBMSs and their approach to database schemas and ICs specification. Also a conceptual level of a graph database design is considered. We propose a sufficient conceptual model based on a binary variant of the ER model and show its relationship to a graph database model, i.e. a mapping conceptual schemas to database schemas. An alternative based on the conceptual functions called attributes is presented. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fusing Detected Humans in Multiple Perception Sensors Network
Authors: Tran Hoang Quang Minh , Le Anh Vu 
Published: March 2018

A fusion method is proposed to keep a correct number of humans from all humans detected by the robot operating system based perception sensor network (PSN) which includes multiple partially overlapped field of view (FOV) Kinects. To this end, the fusion rules are based on the parallel and orthogonal configurations of Kinects in PSN system. For the parallel configuration, the system will decide whether the detected humans staying in FOV of single Kinect or in overlapped FOV of multiple Kinects by evaluating the angles formed between their locations and Kinect original point on top view (x, z plane) of 3D coordination. Then, basing on the angles, the PSN system will keep the person stay in only one FOV or keep the one with biggest ROI if they stay in overlapped FOV of Kinects. In the case of Kinects with orthogonal configuration, 3D Euclidian distances between detected humans are used to determine the group of humans supported to be same human but detected by different Kinects. Then the system, keep the human with a bigger region of interest (ROI) among this group. The experimental results demonstrate the outperforming of the proposed method in various scenarios. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Malware Detection Based on Multiple PE Headers Identification and Optimization for Specific Types of Files
Authors: Zatloukal Filip , Znoj Jiri 
Published: March 2018

This paper follows our previous research in which we made a basic experiment to find out if it is possible to detect malware by multiple PE header detection. The previous results show us that there is a considerable amount of malwares that connect themselves to another file. This paper summarizes our previous results, updates the results and also expands them by adding an optimization method and also by including the scan of another (specific) types of data. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Efsiensi Kinerja Rantai Pasok Gula Semut CV. Menoreh Politan Di Kabupaten Kulon Progo (Efficiency of CV Menoreh Politan Supply Chain Performance Of Coconut Sugar , Kulon Progo Regency)
Authors: Fadhilah Annisa Fajar 
Published: March 2018

CV Menoreh Politan is one of sugar coconut companies in Kalibuko, Kokap, Kulon Progo Regency Yogyakarta. Some of its coconut sugar products are sent to various regions in Indonesia, and some others are occasionally exported. The company, however, had encountered some constraints both in supply and product fulfillment. This research was, therefore, aimed at studying the efficiency of performance at CV Menoreh Politan. The input variables used were order fulfillment cycle, supply chain flexibility, total supply chain cost, cash to cash cycle time, and daily inventory, while input variables for output of supply chain performance were delivery performance, order fulfillment, and conformity with standard. The efficiency of coconut sugar supply chain performance is analyzed by Data Envelopment Analysis (DEA) method with constant return to scale (CRS) assumption. Analysis of farmer efficiency by using Data Envelopment Analysis (DEA) resulted in farmer efficiency level. CV Menoreh Politan has operated efficiently with its 14 partners (24.14 percent), while the remaining 44 farmers of CV Menoreh Politan (75.86 percent) have not reached the maximum efficiency level. The inefficiency of farmers was largely due to the cost of supply chains and long-term enterprise turnover. Overall, the collectors have been fully operational. Similarly, the company has been technically efficient, meaning that in terms of input and output, it has been good.