bluuebunny/crossref_metadata_2025_split huggingface dataset:
HELP: modelling the spectral energy distributions ofHerscheldetected galaxies in the ELAIS N1 field
Authors: Małek K. , Buat V. , Roehlly Y. , Burgarella D. , Hurley P. D. , Shirley R. , Duncan K. , Efstathiou A. , Papadopoulos A. , Vaccari M. , Farrah D. , Marchetti L. , Oliver S. 
Published: September 2018

Aims.TheHerschelExtragalactic Legacy Project (HELP) focuses on the data from ESA’sHerschelmission, which covered over 1300 deg2and is preparing to publish a multi-wavelength catalogue of millions of objects. Our main goal is to find the best approach to simultaneously fitting spectral energy distributions (SEDs) of millions of galaxies across a wide redshift range to obtain homogeneous estimates of the main physical parameters of detected infrared (IR) galaxies.Methods.We perform SED fitting on the ultraviolet(UV)/near-infrared(NIR) to far-infrared(FIR) emission of 42 047 galaxies from the pilot HELP field: ELAIS N1. To do this we use the latest release of CIGALE, a galaxy SED fitting code relying on energy balance, to deliver the main physical parameters such as stellar mass, star formation rate, and dust luminosity. We implement additional quality criteria to the fits by calculatingχ2values for the stellar and dust part of the spectra independently. These criteria allow us to identify the best fits and to identify peculiar galaxies. We perform the SED fitting of ELAIS N1 galaxies by assuming three different dust attenuation laws separately allowing us to test the impact of the assumed law on estimated physical parameters.Results.We implemented two additional quality value checks for the SED fitting method based on stellar mass estimation and energy budget. This method allows us to identify possible objects with incorrect matching in the catalogue and peculiar galaxies; we found 351 possible candidates of lensed galaxies using two complementaryχ2s criteria (stellar and infraredχ2s) and photometric redshifts calculated for the IR part of the spectrum only. We find that the attenuation law has an important impact on the stellar mass estimate (on average leading to disparities of a factor of two). We derive the relation between stellar mass estimates obtained by three different attenuation laws and we find the best recipe for our sample. We also make independent estimates of the total dust luminosity parameter from stellar emission by fitting the galaxies with and without IR data separately.
Knowledge and Practices Regarding Polycystic Ovary Syndrome among Physicians in Europe, North America, and Internationally: An Online Questionnaire-Based Study
Authors: Gibson-Helm Melanie , Dokras Anuja , Karro Helle , Piltonen Terhi , Teede Helena 
Published: September 2018

Background To inform knowledge translation by identifying evidence–practice gaps in polycystic ovary syndrome (PCOS) care and variations between disciplines and across world regions via an online, anonymous, devised questionnaire distributed via professional societies and completed by 1,495 physicians (2015–2016).
Methods Multivariable logistic regression analyses generated adjusted odds ratios (OR) and 95% confidence intervals (CI) for associations between outcome measures and world region, specialty, annual patients with PCOS, age, and sex.
Results Features corresponding to Rotterdam diagnostic criteria were well recognized (e.g., irregular menstrual cycles by 99% of physicians), but psychological implications were recognized only by 29 to 64%. Reproductive endocrinologists were more likely to use Rotterdam diagnostic criteria (OR: 3.1; 95% CI: 2.3–4.3; p < 0.007) than obstetrician-gynecologists. Reproductive (OR: 2.0; 95% CI: 1.5–2.8; p < 0.007) and medical endocrinologists (OR: 3.1; 95% CI: 1.7–5.7; p < 0.007) were more likely to recommend lifestyle management than obstetrician-gynecologists. Physicians in Europe (OR: 4.7; 95% CI: 3.5–6.1; p < 0.007) and other regions (OR: 4.0; 95% CI: 2.8–5.9; p < 0.007) were more likely to use Rotterdam diagnostic criteria than physicians in North America.
Conclusion Knowledge gaps in PCOS care to be addressed internationally include physician awareness of the breadth of PCOS features, application of diagnostic criteria, and recommending lifestyle management effectively.
What Can You Find about Polycystic Ovary Syndrome (PCOS) Online? Assessing Online Information on PCOS: Quality, Content, and User-Friendliness
Authors: Chiu Wei-Ling , Kuczynska-Burggraf Millicent , Gibson-Helm Melanie , Teede Helena , Vincent Amanda , Boyle Jacqueline 
Published: September 2018

Background Polycystic ovary syndrome (PCOS) is a common yet complex condition, where education is vital. It predominantly affects reproductive-aged women, the age group with peak use of the Internet, now a major source of health information. Women with PCOS are dissatisfied with care, and the lack of useful online information is a key concern.
Methods Using a rigorous and systematic methodology, we examined the quality, information content, and user-friendliness of online information about PCOS. Internet searches were conducted in Australia and the United Kingdom in December 2015 using Google, Bing, and Yahoo with different browsers, operating systems, and domain names. A total of 75 Web sites were evaluated and categorized.
Results The majority of Web sites were commercial (41%) and not-for-profit (76%) and were aimed at women only. Less than a third of the Web sites were externally accredited. Commercial Web sites and Web sites targeting only women had the lowest quality scores, while professional-society Web sites and Web sites targeting only HPs scored the highest in quality. Accredited Web sites had higher quality and user-friendliness scores than nonaccredited Web sites.
Conclusion The majority of PCOS Web sites were commercially derived, targeted women, and were not accredited. There is a significant lack of quality, easy-to-read, evidence-based information online for women with PCOS.
Informing Translation: The Accuracy of Information on Websites for Lifestyle Management of Polycystic Ovary Syndrome
Authors: Htet Thaw , Cassar S. , Kuczynska-Burggraf Millicent , Gibson-Helm Melanie , Chiu Wei-Ling , Stepto N. , Moran Lisa , Boyle Jacqueline 
Published: September 2018

Abstract Lifestyle (diet, physical activity [PA], and/or behavioral) interventions are recommended for all women with polycystic ovary syndrome (PCOS) in international guidelines. The internet is a widely used health information resource. However, the accuracy of lifestyle information on PCOS websites is unknown and is reviewed here to inform translation of the international guideline on PCOS. An internet search was conducted with three search engines across different web browsers and countries. Accuracy was assessed through a checklist of 29 questions based on international guidelines for diet, PA, or weight management for the general population and for PCOS with higher scores indicating greater accuracy. Fifteen websites were eligible out of 72 (20%). The total accuracy score was 56 ± 13 (mean ± standard deviation; potential range: −29 to 87) comprising 23 ± 6 for diet (−11 to 33), 15 ± 5 for PA (−9 to 27), and 14 ± 3 for weight management (−8 to 24). A moderate proportion of websites provided general information on appropriate diet (40–80%) or weight management strategies (47–60%), but only 10 to 40% of websites provided information on core foods, discretionary foods, exercise quantity/intensity, energy deficits, or behavioral strategies. Limited websites on PCOS contain information on lifestyle management. The majority provided information on general diet, PA, and weight recommendations but less information on practical implementation of lifestyle change as an identified translation gap for the international guideline on PCOS.
Large-Scale Evidence-Based Guideline Development Engaging the International PCOS Community
Authors: Misso Marie , Tassone Eliza , Costello Michael , Dokras Anuja , Laven Joop , Moran Lisa , Teede Helena ,   on behalf of the International PCOS Network
Published: September 2018

AbstractThe evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) integrates the best available evidence with international, multidisciplinary clinical expertise and consumer preferences to provide health professionals, consumers, and policy makers with high-quality, comprehensive guidance about diagnosing and managing PCOS. Here, we outline the rigorous and systematic process, defined a priori and documented to be reproducible, to minimize bias and maintain transparency, in alignment with the Appraisal of Guidelines for Research and Evaluation (AGREE II) criteria and incorporating the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework that render this PCOS evidence-based guideline credible, trustworthy, reliable, and useable.
Value of Ki-67 Labeling Index in Predicting Recurrence of WHO Grade I Cranial Base Meningiomas
Authors: Matias Jose Gabrielle , Jusue-Torres Ignacio , Martin Brendan , Bajaj Ankush , Borys Ewa , Melian Edward , Barton Kevin , Anderson Douglas E. , Prabhu Vikram C. 
Published: September 2018

Objectives Assess impact of Ki-67 labeling index (LI; Ki-67 LI) on risk of recurrence or progression of WHO grade I meningiomas.
Study Design Retrospective study of adult patients who underwent resection of cranial base meningioma between 2004 and 2016.
Results 272 patients fulfilled criteria for inclusion in the study. Average age was 61.8 years; 196 (72%) were females. Simpson's grade 1 resection was noted in 77 patients (32%), grade 2 in 39 (16%), grade 3 in 36 (15%), and grade 4 in 88 (37%). The Ki-67 LI was low (1–4%) in 214 (78.7%), intermediate (5–9%) in 44 (16.2%), and high (>10%) in 14 (5.2%). Median follow-up was 39 months (IQR: 16–71 months); 221 (87.1%) tumors remained stable or did not recur, 19 (7.4%) recurred, and 14 (5.5%) progressed. Compared with tumors with low Ki-67 LI, those with intermediate Ki-67 LI had 2.47 times (2.47 [1.09–5.59], p = 0.03), and those with high Ki-67 LI had 3.38 times (3.38 [1.16–9.89], p = 0.03) higher risk of recurrence or progression. Tumors with Ki-67 LI > 4% had a shorter time to recurrence or progression (p = 0.01). Recurrence or progression-free survival rates at 3, 5, and 10 years for tumors with low Ki-67 LI were 95%, 89%, and 75%, respectively; tumors with intermediate Ki-67 LI, 87%, 69%, and 52%, respectively; tumors with high Ki-67 LI, 78%, 49%, and 49%, respectively.
Conclusions Following surgical resection of a WHO grade I cranial base meningioma, Ki-67 LI > 4% may predict an increased risk of recurrence or progression of residual tumor.
Transplante de microbiota fecal no tratamento da infecção por Clostridium difficile recorrente—uma revisão
Authors: Meneses Rômulo , Filardi Kaique , Bagano Patricia , Machado Rafaela , Fernandes Sandra 
Published: September 2018

ResumoA infecção por Clostridium difficile (ICD) tem se tornado uma das maiores complicações associadas ao uso de antibióticos sistêmicos. Os antimicrobianos quebram o equilíbrio da flora intestinal colônica, predispondo o indivíduo a infecção por cepas oportunistas, como a ICD, que pode ocasionar, caracteristicamente, um quadro de diarreia e colite. O tratamento padrão para estes casos consiste no uso de metronidazol ou vancomicina por um período de 10 a 14 dias. Porém, estima-se que cerca de 5 a 35% destes pacientes apresentarão falha terapêutica, com novos quadros de ICD. As opções de tratamento para a ICD recorrente permanecem limitadas, mas com terapias promissoras sendo constantemente pesquisadas. O uso de fezes obtidas de um doador saudável para a realização de transplante de microbiota fecal (TMF) vem ganhando espaço nos diversos centros de saúde, com taxas de sucesso reportadas entre 80 e 100%. No entanto, a experiência acerca do assunto ainda permanece limitada, com necessidade de estudos que permitam a criação de um protocolo específico para a realização do TMF.
Cochlear Implantation: An Overview
Authors: Deep Nicholas , Dowling Eric , Jethanamest Daniel , Carlson Matthew 
Published: September 2018

AbstractA cochlear implant (CI) is a surgically implanted device for the treatment of severe to profound sensorineural hearing loss in children and adults. It works by transducing acoustic energy into an electrical signal, which is used to stimulate surviving spiral ganglion cells of the auditory nerve. The past 2 decades have witnessed an exponential rise in the number of CI surgeries performed. Continual developments in programming strategies, device design, and minimally traumatic surgical technique have demonstrated the safety and efficacy of CI surgery. As a result, candidacy guidelines have expanded to include both pre and postlingually deaf children as young as 1 year of age, and those with greater degrees of residual hearing. A growing proportion of patients are undergoing CI for off-label or nontraditional indications including single-sided deafness, retrocochlear hearing loss, asymmetrical sensorineural hearing loss (SNHL) in adults and children with at least 1 ear that is better than performance cut-off for age, and children less than 12 months of age. Herein, we review CI design, clinical evaluation, indications, operative technique, and outcomes. We also discuss the expanding indications for CI surgery as it relates to lateral skull base pathology, comparing CI to auditory brainstem implants, and address the concerns with obtaining magnetic resonance imaging (MRI) in CI recipients.
Economic crisis and mental health – findings from Greece
Authors: Christodoulou N. 
Published: September 2018

Summary
Background: The direct and indirect effects of the economic crisis in Greece have resulted in inequalities, poverty and unemployment. Public health services, social care and welfare have been both severely curtailed and overstretched by increased demand due to higher private care costs and the refugee crisis. For society’s most vulnerable this is beyond an economic crisis, it is a humanitarian crisis. Method: In this narrative review we report a continued rise in suicides, persistent mental health problems in the population, and continued systemic problems despite some successful reforms and slowing of the economic deterioration. Synergistic effects are identified between pre-existing systemic weaknesses, the effects of the crisis, and the effects of austerity. Outlook: Psychiatrists should promote evidence- based interventions, for example preventing mental illness by supporting vulnerable groups and by reducing inequalities. Evidence-based heurism is advocated for, in the interest of outcome. Psychiatrists also have a political role in tackling stigma towards mental illness, refugees and other vulnerable groups, and in promoting resilience and solidarity.
Die Begriffe der Depression und Melancholie im Werk von Johann Christian August Heinroth (1773-1843)
Authors: Steinberg H. 
Published: September 2018

ZusammenfassungDer Leipziger Psychiater Johann Christian August Heinroth definierte den Inhalt des Begriffes Depression neu zur rein symptomatischen Beschreibung einer allgemein traurigen, niedergedrückten Stimmung und damit als recht klar umrissenes psychopathologisches Phänomen. Dieser so vor allem in seinem Lehrbuch von 1818 eingeführte Terminus blieb im Fortgang der Geschichte der Psychiatrie mit dieser Bedeutung erhalten. Davon zu unterscheiden nutzte er zur Bezeichnung der depressiven Erkrankung des Gemüts, das er entsprechend der Vermögenspsychologie neben dem Geist und dem Willen als eine der Grundkräfte der Seele auffasste, innerhalb seiner eigenen, in der Reflexion entstandenen kategorialen Krankheitsklassifikation indes den vorhandenen Begriff der Melancholie.
Biomechanical Evaluation of Suture Anchor versus Transosseous Tunnel Patellar Tendon Repair Techniques
Authors: Sherman Seth L. , Black Brandee , Mooberry Matthew A. , Freeman Katie L. , Gulbrandsen Trevor R. , Milles Jeffrey L. , Evans Laura , Flood David , Pfeiffer Ferris 
Published: September 2018

AbstractThe objective of this study is to compare the cyclic loading strength and ultimate failure load in suture anchor repair versus transosseous tunnel repair of patellar tendons using a cadaver model. Twelve cadaveric patella specimens were used (six matched pairs). Dual-energy X-ray absorptiometry (DXA) measurements were performed to ensure equal bone quality among groups. All right knees were assigned to the suture anchor repair group (n = 6), whereas all left knees were assigned to the transosseous bone tunnel group (n = 6). Suture type and repair configuration were equivalent. After the respective procedures were performed, each patella was mounted into a gripping jig. Tensile load was applied at a rate of 1 Hz between magnitudes of 50 and 150 N, 50 and 200 N, 50 and 250 N, and tensile load at a rate of 0.1 mm/s until failure. Failure was defined as a sharp deviation in the linear load versus displacement curve, and failure mode was recorded. DXA measurements demonstrated equivalence of bone quality between the two groups (p > 0.05). During cyclic load testing, there was only a statistically significant difference between the groups with regard to cyclic loading at the 50 to 200 N loading cycle (p = 0.010). There was no statistically significant difference between the groups with regard to ultimate load to failure (p = 0.43). Failure mode within the suture anchor cohort occurred through anchor pullout except for one, which failed through the tendon. All specimens within the transosseous cohort failed through the midsubstance of the tendon except for one, which failed through suture breakage. Suture anchor repair demonstrated a similar biomechanical profile regarding cyclic loading and ultimate load to failure when compared with “gold standard” transosseous tunnel patellar tendon repair with a trend toward less gapping in the suture anchor group. Using suture anchors for repair of the patella tendon has similar biomechanical properties to transpatellar tunnels but may provide other clinical advantages.
Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders
Authors: Li He , Lu Lu , Li Xuejin , Buffet Pierre A. , Dao Ming , Karniadakis George E. , Suresh Subra 
Published: September 2018

SignificanceThe interendothelial slit (IES) is the narrowest circulatory pathway in the human spleen where aged and diseased red blood cells (RBCs) are filtered. We use a two-component RBC model to probe the dynamics of healthy and diseased RBCs traversing IES. Our simulations reveal that the spleen not only senses and clears RBCs with abnormal shapes and deformability but also alters the geometries of RBCs that contain protein defects arising from hereditary blood disorders. The framework presented here is sufficiently general to be extended to elucidate the pathophysiological roles of the spleen in other blood diseases.
Citrus peel polymethoxyflavones, sudachitin and nobiletin, induce distinct cellular responses in human keratinocyte HaCaT cells
Authors: Abe Shogo , Hirose Saki , Nishitani Mami , Yoshida Ichiro , Tsukayama Masao , Tsuji Akihiko , Yuasa Keizo 
Published: September 2018

ABSTRACT
A variety of polyphenols have been isolated from plants, and their biological activities have been examined. Sudachitin (5,7,4′-trihydroxy-6,8,3′-trimethoxyflavone) is a polymethoxyflavone that is isolated from the peel of Citrus sudachi. Although we previously reported that sudachitin possesses an anti-inflammatory activity, its other biological activities are not yet understood. In this study, we report a novel biological activity of sudachitin, which selectively induced apoptosis in human keratinocyte HaCaT cells. Another polymethoxyflavone, nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone), promoted autophagy but not apoptosis in HaCaT cells. On the other hand, 3′-demethoxysudachitin (5,7,4′-trihydroxy-6,8-dimethoxyflavone) failed to induce apoptosis and autophagy. These results show that three polymethoxyflavones have different effects on apoptosis and autophagy in HaCaT cells. Understanding the structure and biological activity of polymethoxyflavones may lead to the discovery of potential candidates for cancer drug development without significant toxic side effects.
Abbreviations: ROS: reactive oxygen species; DMSO: dimethyl sulfoxide; MTT: 3-(4, 5-dimethylthiazol-2yl)-2, 5-diphenyltetrazolium bromide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; PARP: poly(ADP-ribose) polymerase; PI: propidium iodide; MAPK: mitogen-activated protein kinase.
Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation
Authors: Liang Ying , Sasaki Ikumi , Takeda Yuki , Zhu Beiwei , Munemasa Shintaro , Nakamura Toshiyuki , Murata Yoshiyuki , Nakamura Yoshimasa 
Published: September 2018

ABSTRACT
Benzyl isothiocyanate (BITC) is an organosulfur compound derived from cruciferous vegetables and papaya seeds. In this study, we investigated the effect of BITC on the lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation. The treatment of BITC during the differentiation-inducing stage significantly ameliorated the lipid accumulation, whereas it had no inhibitory effect during the differentiation-maintaining stage. BITC also significantly suppressed the mRNA expression of the adipocyte-specific markers, such as CCAAT/enhancer-binding protein α (C/EBPα), C/EBPβ, C/EBPδ and peroxisome proliferator-activated receptor γ. BITC significantly inhibited the phosphorylation of extracellular signal-regulated kinase phosphorylation, whereas it enhanced that of AMP-activated protein kinase. Furthermore, BITC significantly suppressed the intracellular 2-deoxyglucose uptake as well as glucose transporter 4 expression. These results suggest that inhibition of the adipocyte differentiation and glucose uptake may mainly contribute to the inhibitory effect of BITC on the lipid accumulation in 3T3-L1 preadipocytes.
Abbreviations: PPARγ: peroxisome proliferator-activated receptor γ; CEBP: CCAAT/enhancer-binding protein; GLUT4: glucose transporter 4; AMPK: AMP-activated protein kinase; ERK1/2: extracellular signal-regulated kinase 1/2; MAPK: a mitogen-activated protein kinase; ITCs: isothiocyanates; BITC: benzyl isothiocyanate; FBS: fetal bovine serum; CS: calf serum; AITC: allyl ITC; IBMX: 3-isobutyl-1-methylxanthine; LDH: lactate dehydrogenase; KRH: Krebs-Ringer-Hepes-bicarbonate; 2-DG: 2-deoxy-d-glucose
Vesicular trafficking plays a role in centriole disengagement and duplication
Authors: Xie Shuwei , Reinecke James B. , Farmer Trey , Bahl Kriti , Yeow Ivana , Nichols Benjamin J. , McLamarrah Tiffany A. , Naslavsky Naava , Rogers Gregory C. , Caplan Steve 
Published: September 2018

Centrosomes are the major microtubule-nucleating and microtubule-organizing centers of cells and play crucial roles in microtubule anchoring, organelle positioning, and ciliogenesis. At the centrosome core lies a tightly associated or “engaged” mother–daughter centriole pair. During mitotic exit, removal of centrosomal proteins pericentrin and Cep215 promotes “disengagement” by the dissolution of intercentriolar linkers, ensuring a single centriole duplication event per cell cycle. Herein, we explore a new mechanism involving vesicular trafficking for the removal of centrosomal Cep215. Using small interfering RNA and CRISPR/Cas9 gene-edited cells, we show that the endocytic protein EHD1 regulates Cep215 transport from centrosomes to the spindle midbody, thus facilitating disengagement and duplication. We demonstrate that EHD1 and Cep215 interact and show that Cep215 displays increased localization to vesicles containing EHD1 during mitosis. Moreover, Cep215-containing vesicles are positive for internalized transferrin, demonstrating their endocytic origin. Thus, we describe a novel relationship between endocytic trafficking and the centrosome cycle, whereby vesicles of endocytic origin are used to remove key regulatory proteins from centrosomes to control centriole duplication.