bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of self‐transcendence traits with in vivo dopamine D2/3 receptor availability and functional connectivity: An [18F]fallypride PET and fMRI study
Authors: Kim Jeong‐Hee , Choe Yi‐Seul , Cumming Paul , Son Young‐Don , Kim Hang‐Keun , Joo Yo‐Han , Kim Jong‐Hoon 
Published: June 2019

AbstractGenetic research has implicated dopamine neurotransmission in the expression of the self‐transcendence trait in humans. However, molecular imaging of dopaminergic markers is undocumented in relation to this personality trait. In this multimodal imaging study, we first investigated the relationship between the self‐transcendence trait and in vivo dopamine D2/3 receptor availability using [18F]fallypride positron emission tomography (PET). We next conducted seed‐based functional connectivity analyses using resting‐state functional magnetic resonance imaging (rs‐fMRI) data with regions derived from the PET analysis as seeds to explore the functional significance of D2/3 receptor availability foci associated with the self‐transcendence trait. Twenty‐one healthy subjects underwent high‐resolution PET with [18F]fallypride and a subset of 18 subjects also completed 3‐Tesla rs‐fMRI. The Temperament and Character Inventory was used to measure the self‐transcendence trait. A voxel‐based whole brain analysis revealed that the [18F]fallypride binding potential (BPND) within the cluster of the left insula was significantly positively correlated with self‐transcendence trait scores. A region‐of‐interest analysis also showed a significant positive correlation between self‐transcendence and [18F]fallypride BPND in the left insula. The exploratory [18F]fallypride BPND seed‐based rs‐fMRI analysis showed that the functional connectivity from the left insula seed to the prefrontal cortices (including the inferior frontal region) was negatively associated with self‐transcendence trait scores. The results of the present study suggest that D2/3 receptor‐mediated neurotransmission in the left insula may constitute a significant neurobiological factor in the self‐transcendence trait. The negative associations between BPND seed‐based functional connectivity and self‐transcendence trait scores may suggest reduced prefrontal control in this personality trait.
Generalized screw dislocations interacting with interfacial secondary crack in magneto‐electro‐elastic solid
Authors: Zeng Xin , Li Jia , Liu Feng , Wen Pihua 
Published: June 2019

AbstractThe interaction between generalized screw dislocation and two asymmetrical interfacial secondary cracks emanating from an elliptic blunt crack tip in magneto‐electro‐elastic solid is investigated. Utilizing the complex potential method, the closed‐form solutions for complex potentials and generalized stress fields are derived. In some limiting cases, the present solutions can reduce to the well‐known results. Moreover, many new solutions for special cases are discussed. The energy release rate at the right interfacial secondary crack tip and the image force acting on dislocation are also calculated. Numerical calculations are given for analyzing the effects of variable parameters, such as location of the dislocation, materials constants and geometrical parameters of interfacial secondary crack. The results show that the long left interfacial secondary crack or the blunt crack with the high passivation rate enhances the influence of the dislocation on the energy release rate at the right interfacial secondary crack tip. In addition, the energy release rate increases with the increment of elastic coefficient of the other half‐plane, but decreases with the increment of dielectric coefficient or magnetic permeability coefficient.
The Relationship Between Supply Constraints and House Price Dynamics in the Netherlands
Authors: Öztürk Bahar , van Dijk Dorinth , van Hoenselaar Frank , Burgers Sander 
Published: June 2019

AbstractWe analyze the effect of supply constraints on the dynamics of house prices in the Netherlands. In particular, we look at whether income shocks lead to stronger house price increases in regions characterized with higher supply constraints. We use a panel dataset that contains 316 municipalities over the years 1987–2016. Municipalities are divided in three equally sized groups according to the extent of supply constraints present in each municipality. Our results suggest that income shocks lead to significantly larger increases in house prices in municipalities that are relatively more supply constrained. This holds both in the short- and the long-term. The degree of mean reversion and persistence, however, do not seem to significantly differ between the three groups of municipalities.
Discussing Sexual Health in the Medical Oncologist’s Practice: Exploring Current Practice and Challenges
Authors: Krouwel E. M. , Albers L. F. , Nicolai M. P. J. , Putter H. , Osanto S. , Pelger R. C. M. , Elzevier H. W. 
Published: June 2019

AbstractSexuality is a significant quality-of-life concern for many cancer patients. Patients may be disadvantaged if they are not informed and not offered sexual health care. We sought to reveal oncologists’ current practice and opinions concerning sexual counselling. The aim of this study was to explore the knowledge, attitude and practice patterns of Dutch medical oncologists regarding treatment-related sexual dysfunction. Questionnaires were sent to 433 members of the Dutch Society of Medical Oncology. The majority (81.5%) of the 120 responding medical oncologists (response rate 30.6%) stated they discussed sexual function with fewer than half of their patients. At the same time, 75.8% of the participating oncologists agreed that addressing sexual function is their responsibility. Sexual function was discussed more often with younger patients and patients with a curative treatment intent. Barriers for avoiding discussing sexual function were lack of time (56.1%), training (49.5%) and advanced age of the patient (50.4%). More than half (64.6%) stated they had little knowledge about the subject and the majority (72.9%) wanted to acquire additional training in sexual function counselling. Medical oncologists accept that sexual function counselling falls within their profession, yet they admit to not counselling patients routinely concerning sexual function. Only in a minority of cases do medical oncologists inform their patients about sexual side effects of treatment. Whether they counsel patients is related to how they view patient’s prognosis, patient’s age, and self-reported knowledge. Findings indicate there is a role for developing education and practical training.
Epinephrine in cardiac arrest: The PARAMEDIC2 trial
Authors: Moore Jarrett , Sanderson Mark , Abu-Laban Riyad B. 
Published: June 2019

Abstract Link:http://www.nejm.org/doi/10.1056/NEJMoa1806842Full citation: Perkins GD, Ji C, Deakin CD, et al. A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med 2018; epub, NEJMoa1806842.Article type: TherapyRatings: Methods – 4/5 Usefulness – 3.5/5
Economic Vulnerability and Partisanship in Latin America
Authors: Altamirano Melina 
Published: June 2019

ABSTRACTA significant proportion of the population in Latin America depends on the informal economy and lacks adequate protection against a variety of economic risks. This article suggests that economic vulnerability affects the way individuals relate to political parties. Given the truncated structure of welfare states in the region, citizens in the informal sector receive lower levels of social security benefits and face higher economic uncertainty. This vulnerability makes it difficult for voters to establish strong programmatic linkages with political parties because partisan platforms and policies do not necessarily represent their interests and needs. Using cross-national microlevel data, this study shows that individuals living in informality are skeptical about state social policy efforts and exhibit weaker partisan attachments. The findings suggest that effective political representation of disadvantaged groups remains a challenge in Latin American democracies.
Whaling intelligence: news, facts and US-American exploration in the Pacific
Authors: LÜTTGE FELIX 
Published: June 2019

AbstractThis paper investigates the history of a discursive figure that one could call the intelligent whaler. I argue that this figure's success was made possible by the construal and public distribution of whaling intelligence in an important currency of science – facts – in the preparatory phase for the United States Exploring Expedition (1838–1842). The strongest case for the necessity of the enterprise was New England whalers who were said to cruise uncharted parts of the oceans and whose discoveries of uncharted islands were reported in the local press. The document that stood at the core of the lobbying for an expedition was a table that newspaperman and public lecturer Jeremiah Reynolds had compiled after interviewing whaling captains in the country's principal whaling ports. Presenting whalers’ experience in tabular and synoptic form, Reynolds's table helped forge the figure of the ‘intelligent whaler’, a mariner who had better geographical knowledge than other seafarers. By investigating the paper technologies that produced the ‘intelligent whaler’, this paper shows how Reynolds's translation of ‘whaling intelligence’ from news into facts marks the beginning of the intelligent whaler's long career in US-American debates about expansionism, exploration and science.
Effects of nut and seed consumption on markers of glucose metabolism in adults with prediabetes: a systematic review of randomised controlled trials
Authors: Ntzouvani Agathi , Antonopoulou Smaragdi , Nomikos Tzortzis 
Published: June 2019

AbstractThe primary aim was to investigate the effects of nut and seed consumption on markers of glucose metabolism in adults with prediabetes. Studies with a randomised controlled trial (RCT) design, comparing the effects of a diet containing nuts or seeds against a diet without nuts or seeds in adults with prediabetes, were considered eligible. Primary outcome measures included fasting plasma glucose (FPG), 2-h plasma glucose during oral glucose tolerance test and glycated Hb (HbA1c) concentrations. Studies were identified by searching PubMed and Scopus electronic databases and by checking full texts and reference lists of relevant records. Risk of bias was assessed using the Cochrane Collaboration’s tool. We included five RCT involving 371 adults with prediabetes or at risk of diabetes; three RCT investigated the effects of whole nut consumption and two the effects of ground flaxseed consumption. Consumption of 57 g/d pistachios or mean intake of 60 g/d almonds for 4 months improved FPG and fasting plasma insulin (FPI) concentrations, insulin resistance, cellular glucose uptake in lymphocytes andβ-cell function. Consumption of 56 g/d walnuts for 6 months was not found to affect FPG or HbA1c concentrations. Consumption of 13 g/d flaxseed for 3 months improved FPG and FPI concentrations and insulin resistance. In a second study, however, flaxseed consumption was not found to affect markers of glucose metabolism. The risk of bias was generally low, thus the reported results could be reliable. Further investigation of nut and seed consumption effects in the field of prediabetes is warranted.
The troublesome genus Thamnolia (lichenized Ascomycota)
Authors: JØRGENSEN Per M. 
Published: June 2019

AbstractA new neotypus is designated for Thamnolia vermicularis in accordance with the protologue. The taxonomy is best reflected by molecular evidence which recognizes three subspecies: the widespread subsp. vermicularis, and the geographically more restricted subsp. taurica (in the eastern Alps) and subsp. tundrae (in the Arctic region). The nomenclatural consequences resulting from these changes require that two new combinations are made.
Novel polymorphic microsatellite loci inAnisakis pegreffiiandA. simplex(s. s.) (Nematoda: Anisakidae): implications for species recognition and population genetic analysis
Authors: Mattiucci Simonetta , Bello Eleonora , Paoletti Michela , Webb Steve C. , Timi Juan T. , Levsen Arne , Cipriani Paolo , Nascetti Giuseppe 
Published: June 2019

AbstractThe species ofAnisakisconstitute one of the most widespread groups of ascaridoid nematodes in the marine ecosystem. Three closely related taxa are recognised in theA. simplex(s. l.) complex, i.e.A. pegreffii,A. simplex(s. s.) andA. berlandi.They are distributed in populations of their intermediate/paratenic (fish and squids) and definitive (cetaceans) hosts. A panel of seven microsatellite loci (Anisl 05784,Anisl 08059,Anisl 00875,Anisl 07132, Anisl 00314, Anisl 10535andAnisl 00185), were developed and validated on a total ofN= 943 specimens ofA. pegreffiiandA. simplex(s. s.), collected in fish and cetacean hosts from allopatric areas within the range of distribution of these parasite species. In addition, the locusAnisl 7, previously detected in thoseAnisakisspp., was investigated. The parasites were first identified by sequence analysis of the EF1α-1 nDNA. The panel of the microsatellites loci here developed have allowed to: (i) detect diagnostic microsatellite loci between the two species; (ii) identify specimens of the two speciesA. pegreffii, A. simplex(s. s.) in a multi-marker nuclear genotyping approach; (iii) discover two sex-linked loci in bothAnisakisspecies and (iv) estimate levels of genetic differentiation at both the inter- and intra-specific level.
Articular Geometry Reconstruction for Knee Joint with a Wearable Compliant Device
Authors: Guo Jiajie , Wang Zihang , Fu Jianyong , Lee Kok-Meng 
Published: June 2019

SummaryNonlinear articular geometries of biological joints have contributed to highly agile and adaptable human-body motions. However, human–machine interaction could potentially distort natural human motions if the artificial mechanisms overload the articular surfaces and constrain biological joint kinematics. It is desired to better understand the deformable articular geometries of biological joints in vivo during movements for design and control of wearable robotics. An articular geometry reconstruction method is proposed to measure the effective articular profile with a wearable compliant device and illustrated with its application to knee-joint kinematic analysis. Regarding the joint articulation as boundary constraints for the compliant mechanism, the equivalent articular geometry is constructed from the beam deformations driven by knee motions, where the continuous deformations are estimated with strain data from the embedded sensors. Both simulated analysis and experimental validation are presented to justify the proposed method.
Genetic aetiologies should be considered in paediatric cases of acute heart failure presumed to be myocarditis
Authors: Brown Emily E. , McMilllan Kristen Nelson , Halushka Marc K. , Ravekes William J. , Knight Margaret , Crosson Jane E. , Judge Daniel P. , Murphy Anne M. 
Published: June 2019

AbstractThere are a variety of causes of acute heart failure in children including myocarditis, genetic/metabolic conditions, and congenital heart defects. In cases with a structurally normal heart and a negative personal and family history, myocarditis is often presumed to be the cause, but we hypothesise that genetic disorders contribute to a significant portion of these cases. We reviewed our cases of children who presented with acute heart failure and underwent genetic testing from 2008 to 2017. Eighty-seven percent of these individuals were found to have either a genetic syndrome or pathogenic or likely pathogenic variant in a cardiac-related gene. None of these individuals had a personal or family history of cardiomyopathy that was suggestive of a genetic aetiology prior to presentation. All of these individuals either passed away or were listed for cardiac transplantation indicating genetic testing may provide important information regarding prognosis in addition to providing information critical to assessment of family members.
Lessons learned in the use of clinical registry data in a multi-centre prospective study: the Pediatric Heart Network Residual Lesion Score Study
Authors: Prospero Carol J. , Trachtenberg Felicia L. , Pemberton Victoria L. , Pasquali Sara K. , Anderson Brett R. , Ash Kathleen E. , Bainton Jessica , Dunbar-Masterson Carolyn , Graham Eric M. , Hamstra Michelle S. , Hollenbeck-Pringle Danielle , Jacobs Jeffrey P. , Jacobs Marshall L. , John Rija , Lambert Linda M. , Oster Matthew E. , Swan Elizabeth , Waldron Abigail , Nathan Meena ,   for the Pediatric Heart Network Investigators
Published: June 2019

AbstractBackground:Using existing data from clinical registries to support clinical trials and other prospective studies has the potential to improve research efficiency. However, little has been reported about staff experiences and lessons learned from implementation of this method in pediatric cardiology.Objectives:We describe the process of using existing registry data in the Pediatric Heart Network Residual Lesion Score Study, report stakeholders’ perspectives, and provide recommendations to guide future studies using this methodology.Methods:The Residual Lesion Score Study, a 17-site prospective, observational study, piloted the use of existing local surgical registry data (collected for submission to the Society of Thoracic Surgeons-Congenital Heart Surgery Database) to supplement manual data collection. A survey regarding processes and perceptions was administered to study site and data coordinating center staff.Results:Survey response rate was 98% (54/55). Overall, 57% perceived that using registry data saved research staff time in the current study, and 74% perceived that it would save time in future studies; 55% noted significant upfront time in developing a methodology for extracting registry data. Survey recommendations included simplifying data extraction processes and tailoring to the needs of the study, understanding registry characteristics to maximise data quality and security, and involving all stakeholders in design and implementation processes.Conclusions:Use of existing registry data was perceived to save time and promote efficiency. Consideration must be given to the upfront investment of time and resources needed. Ongoing efforts focussed on automating and centralising data management may aid in further optimising this methodology for future studies.
Lessons in Post-Disaster Self-Care From 9/11 Paramedics and Emergency Medical Technicians
Authors: Smith Erin , Walker Tony , Burkle Frederick M. 
Published: June 2019

AbstractObjective:The objective of this study was to explore preferred self-care practices among paramedics and emergency medical technicians (EMTs) who responded to the September 11, 2001 terrorist attack (9/11) in New York City (New York USA).Design, Setting, and Participants:Qualitative research methodology with convenience and subsequent snowball sampling was utilized. Participants were adult (at least 18 years of age) paramedics or EMTs who self-reported as responding to the 9/11 terrorist attack in New York City.Main Outcome Measures:Preferred self-care practices; participant characteristics; indications and patterns of self-care use; perceived benefits and harms; and views on appropriate availability of support and self-care services were the main outcome measures.Results:The 9/11 paramedic and EMT participants reported a delay in recognizing the need for self-care. Preferred physical self-care practices included exercise, good nutrition, getting enough sleep, and sticking to routine. Preferred psychosocial self-care practices included spending time with family and friends, participating in peer-support programs and online support forums, and routinely seeing a mental health professional. Self-care was important for younger paramedics and EMTs who reported having less-developed supportive infrastructure around them, as well as for retiring paramedics and EMTs who often felt left behind by a system they had dedicated their lives to. Access to cooking classes and subsidized gym memberships were viewed as favorable, as was the ability to include family members in self-care practices.Conclusion(s):A range of physical and psychosocial self-care practices should be encouraged among paramedic students and implemented by Australian ambulance services to ensure the health and well-being of paramedics throughout their career and into retirement.
Suicidal ideation and behavior in adults with major depressive disorder treated with vortioxetine: post hoc pooled analyses of randomized, placebo-controlled, short-term and open-label, long-term extension trials
Authors: Mahableshwarkar Atul R. , Affinito John , Reines Elin Heldbo , Xu Judith , Nomikos George , Jacobsen Paula L. 
Published: June 2019

ObjectivesThis study aimed to evaluate the risk of suicidal ideation and behavior associated with vortioxetine treatment in adults with major depressive disorder (MDD).MethodsSuicide-related events were evaluated post hoc using 2 study pools: one short-term pool of 10 randomized, placebo-controlled studies (6–8 weeks) and another long-term pool that included 3 open-label extension studies (52 weeks). Evaluation of suicide-related events was performed using Columbia-Suicide Severity Rating Scale (C-SSRS) scores and treatment-emergent adverse events (TEAEs) data.ResultsAt baseline, the percentage of patients reporting any C-SSRS ideation or behavior events in short-term studies was similar between placebo (14.7%), vortioxetine (19.8%, 13.0%, 11.2%, and 13.7% for 5-, 10-, 15-, and 20-mg groups, respectively), and duloxetine active reference (13.2%) and did not change throughout the 6- to 8-week treatment period for placebo (17.0%), vortioxetine (19.3%, 13.5%, 12.6%, and 15% for 5-, 10-, 15-, and 20-mg groups, respectively), or duloxetine (11.3%). The incidence of suicide-related events for TEAEs in the short-term pool was 0.4% for placebo, 0.2% or 1.0% for vortioxetine 5 mg or 10 mg, and 0.7% each for vortioxetine 15 mg and 20 mg, as well as duloxetine. After 52-week treatment with vortioxetine, suicidal ideation based on C-SSRS was 9.8%, C-SSRS suicidal behavior was 0.2%, and the incidence of suicide-related events based on TEAEs was <1%. There were no completed suicides in any study.ConclusionsVortioxetine is not associated with increased risk of suicidal ideation or behavior in MDD patients.
VGAM: Compact and Low‐Power Mass Spectrometer‐Based Instrumentation for Volcanic Gas Monitoring
Authors: McMurtry Gary M. , Dasilveira Luis A. , Falinski Kim A. , Fischer Tobias P. 
Published: June 2019

AbstractCompact mass spectrometers (MSs) can provide simultaneous multispecies analysis with high sensitivity and precision. For volcanic gas monitoring in situ, instrumental mass spectrometry requires reliability and ruggedness combined with low power usage and portability. The Volcanic Gas Analytical Monitor (VGAM) is capable of quantitative molecular analysis of a variety of atmospheric and volcanic gases in a single sensor by ion trap mass spectrometry. These gases include H2, He, H2O, N2, O2, Ar, NO, N2O, CO, CO2, H2S, SO, SO2, and CH4. Unlike previous field instruments using magnetic sector and quadrupole MSs with vacuums backed by compact turbomolecular pumps, the VGAM uses a low‐power autoresonant ion trap MS and nonevaporable getter‐ion pumped vacuum that operates at only 25‐W total power, which is often the power requirement for just the MS. Ratiometric mass spectral response is combined with total pressure measurements to report absolute partial pressures. Data are generated in real time and are recorded to internal flash memory. Relatively low power (<1 W) data telemetry to remote sites is possible. Analysis of volcanic plumes, fumaroles, and solfatara fields is accomplished by direct inlet of gases, after trapping as much excess water vapor in both the external and internal foreline as possible. We report herein on the VGAM autorun and postprocessing procedures, initial calibration results for CO2, and the results of a brief field deployment at Sulfur Banks solfatara field, Kilauea Volcano, Hawaii.