bluuebunny/crossref_metadata_2025_split huggingface dataset:
Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer
Authors: Yu Haibo , Song Hongliang , Ma Zhongwu , Ji Wu 
Published: January 2019

AbstractIt has been demonstrated that miR-539 plays an important role in the development and progression of tumors. The purpose of this study was to analyze the correlation between the expression level of miR-539 and the clinicopathological features and prognosis of patients with pancreatic cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the expression level of miR-539 in 60 patients with pancreatic cancer. It was found that miR-539 gene expression was down-regulated in pancreatic cancer compared with that in paracancerous tissues. In addition, the expression level of miR-539 was inversely correlated with tumor differentiation (poorly to moderately differentiated vs. well differentiated, P=0.006), lymph node metastasis (positive vs. negative, P=0.006), clinical stage (III-IV vs. I-II, P=0.002), CA199 (≥200 vs. <200, P=0.019) and distant metastasis (positive vs. negative, P=0.035). The survival time of pancreatic cancer patients with low expression of miR-539 was significantly shorter than that of patients with high expression of miR-539. Multivariate analysis suggested that miR-539 expression level was an independent prognostic indicator for patients with pancreatic cancer (P=0.025). Down-regulation of miR-539 may be a potentially unfavorable prognostic factor for patients with pancreatic cancer, and further studies are needed to confirm our conclusion in the future.
Criteria for New Element Discovery: Providing Assurance in a Field of Allure and Romance
Authors: Hofmann Sigurd 
Published: January 2019

Abstract
Allure and romance are rarely expected in an article presented under the bulky headline “Criteria that must be satisfied for the discovery of a new chemical element to be recognized.” However, the members of the Transfermium Working Group (TWG) worked out a most fascinating publication on a difficult subject during the years from 1988 to 1991 [1].
Looking Backwards and Forwards at the Development of the Periodic Table
Authors: Scerri Eric 
Published: January 2019

Abstract
Since the periodic table has reached the ripe old age of 150 years it may be an appropriate time to look back at the development of this unique scientific icon. It is also an opportunity to look forwards to any changes that the periodic table may undergo in view of the ever-growing list of new elements that continue to be synthesized. The way that the past and future will be examined in this article will be to follow a main thread that focuses on the number of columns in the periodic table at various stages in its development.
Isotopic Abundances and Atomic Weights: IUPAC Commission II.1 Today
Authors: Meija Juris 
Published: January 2019

Abstract
It is hard to imagine IUPAC without the Periodic Table, and in turn, without atomic weights. As IUPAC celebrates its centennial, its oldest body, the Commission on Isotopic Abundances and Atomic Weights (CIAAW) turns 120. The parent Commission was formed in March 1899 and its inaugural task was to decide the atomic weight standard: should it be based on hydrogen or oxygen? Although the issue was settled in favor of oxygen, when the CIAAW formally joined the IUPAC in 1919, the question of the atomic weight scale was back for debate suggesting that many issues before this Commission transcend their scientific merit. In fact, many view the Periodic Table and changes therein as a part of larger cultural fabric of science so any changes are likely to be debated for a long time.
Combining Data Analytics with Team Feedback to Improve the Estimation Process in Agile Software Development
Authors: Vetrò Antonio , Dürre Rupert , Conoscenti Marco , Fernández Daniel Méndez , Jørgensen Magne 
Published: January 2019

Abstract
We apply a mixed research method to improve the user stories estimation process in a German company following agile software development. We combine software project data analytics with elicitation of teams’ feedback, identify root causes for wrong estimates and propose an improved version of the estimation process. Three major changes are adopted in the new process: a shorter non numerical scale for story points, an analogy-based estimation process, and retrospectives analyses on the accuracy of previous sprints estimates. The new estimation process is applied on a new project, and an improvement of estimates accuracy from 10% to 45% is observed.
Strong Reachability of Reactions with Reversible Steps
Authors: Virágh Eszter , Kiss Bálint 
Published: January 2019

Abstract
The controllability of reactions is an important issue in the chemical industry. The control of reactions is of great practical interest in order to ensure the energy- and time-efficient production of compounds. This paper studies the dynamical models of some chemical reactions in order to verify their controllability with regard to a candidate input signal, namely the change in the ambient temperature of a reaction.
Production of A Biolubricant by Enzymatic Esterification: Possible Synergism Between Ionic Liquid and Enzyme
Authors: Bedő Zsófia , Bélafi-Bakó Katalin , Nemestóthy Nándor , Gubicza László 
Published: January 2019

Abstract
The possible replacement of lubricants with fossil-fuel sources and the manufacture of biolubricants with more beneficial features were studied. Oleic acid and isoamyl alcohol were reacted with an enzyme in an ionic liquid. During the reaction conventional as well as microwave heating was applied. After the experimental determination of the optimal reaction parameters, it was unexpectedly found that a synergistic effect occurred by applying ionic-liquid and microwave-heat treatment simultaneously. The enzyme exhibited a much higher level of activity than the value expected based on the measurements carried out separately by using an ionic liquid instead of an organic solvent and microwave-heat treatment or a conventional method. In the experiments with recycled enzyme it was found that ionic liquid maintained the enzyme more effectively, as if it was immobilized by it: the enzyme managed to maintain its activity and recycling ability.
The Initial Magnetic Susceptibility of Dense Aggregated Dipolar Fluids
Authors: Nagy Sándor 
Published: January 2019

Abstract
To correlate the dipole moment and density dependence of the initial magnetic susceptibility on the basis of the former related theories and the probability analysis of chain formation, physically based analytical correlation equation was derived. After the local magnetic field strength and the chaining probability between two particle have been determined the chain and particle distributions came from the geometric distribution. The initial magnetic susceptibility was resulted from the summation of Langevin initial susceptibility of k-length chains. Two particles were considered in a chain if the interaction energy between them was below a certain limit. By varying slightly this energy limit around 70–75 % good agreement has been obtained between the simulation and theoretical data. Monte Carlo simulations were used to calculate the initial magnetic susceptibility of dipolar hard sphere system at different dipole moments and densities.
Effects of Different Heat Treatments on The Chemical and Microbiological Characteristics of Egg-Free and Quail Egg Dried Pasta
Authors: Szedljak Ildikó , Tóth Viktória , Tormási Judit , Kovács Anikó , Somogyi László , Sipos László , Kiskó Gabriella 
Published: January 2019

Abstract
In Hungary, dried pasta products are very popular amongst all groups of society. In recent years the demand for not only dried pasta made from hen eggs (Gallus gallus domesticus) but from alternative types of ingredients has increased. However, according to the literature the chemical and microbiological characteristics of this type of pasta have yet to be studied in depth. The effects of the use of quail eggs and heat treatments at different temperatures were studied by chemical and microbiological measurements. The activity of oxidative enzymes and nutritional characteristics (water-soluble total polyphenol content, water-soluble antioxidant capacity, peroxidase enzymatic activity, water-soluble protein content and yellow pigment content) was tested during our experiments. The data were evaluated by relevant statistical methods. Significant differences were found both between heat treatments and between the egg content of the dried pasta samples. The peroxidase enzymatic activity and yellow pigment content increased with temperature. However, the usage of quail eggs provides a higher water-soluble protein content and water-soluble antioxidant capacity. The presence of microorganisms is decreased by increasing the drying temperature. The number of all the examined microorganisms was within limits.
Optimal Design and Operation of Buffer Tanks Under Stochastic Conditions
Authors: Tarcsay Bálint Levente , Mihálykó-Orbán Éva , Mihálykó Csaba 
Published: January 2019

Abstract
Safety regulations demand the elimination of random mistakes and the reliable operation of production units. However, the control and maintenance of batch and semi-continuous processes haalways been difficult. In this paper, a way of preventing malfunctions in batch and semi-continuous processes is presented by using appropriately designed buffer tanks. A stochastic model was investigated in which batch and continuous subsystems were linked by an intermediate storage tank. The main concern was the reliability of the system. Reliable operation was defined as neither the exhaustion of raw materials nor the excessive accumulation of them. The counting processes that describe the random batch-input and random batch-output processes are supposed to be independent homogeneous Poisson processes with different rates. By introducing a function that describes the material in storage, reliable operation is defined as when this function satisfies two inequalities for a time interval of any duration. By applying probabilistic methods, an integral equation is set up for the the reliability. Nevertheless, its analytical solution cannot be determined, hence the values according to a Monte Carlo simulation are approximated. By applying this method, a link could be identified between the necessary initial buffer and tank capacities that belong to a reliability level. Economic investigations were conducted to help determine the optimal initial buffer and tank capacities that satisfy the appointed reliability level.
Analyzing a generalized pest-natural enemy model with nonlinear impulsive control
Authors: Li Changtong , Tang Sanyi 
Published: January 2019

AbstractDue to resource limitation, nonlinear impulsive control tactics related to integrated pest management have been proposed in a generalized pest-natural enemy model, which allows us to address the effects of nonlinear pulse control on the dynamics and successful pest control. The threshold conditions for the existence and global stability of pest-free periodic solution are provided by Floquet theorem and analytic methods. The existence of a nontrivial periodic solution is confirmed by showing the existence of nontrivial fixed point of the stroboscopic mapping determined by time snapshot, which equals to the common impulsive period. In order to address the applications of generalized results and to reveal how the nonlinear impulses affect the successful pest control, as an example the model with Holling II functional response function is investigated carefully. The main results reveal that the pest free periodic solution and a stable interior positive periodic solution can coexist for a wide range of parameters, which indicates that the local stability does not imply the global stability of the pest free periodic solution when nonlinear impulsive control is considered, and consequently the resource limitation (i.e. nonlinear control) may result in difficulties for successful pest control.
On further refinements for Young inequalities
Authors: Furuichi Shigeru , Moradi Hamid Reza 
Published: January 2019

AbstractIn this paper sharp results on operator Young’s inequality are obtained. We first obtain sharp multiplicative refinements and reverses for the operator Young’s inequality. Secondly, we give an additive result, which improves a well-known inequality due to Tominaga. We also provide some estimates for the difference A1/2(A−1/2BA−1/2)vA1/2-{(1-v)A + vB} for v∉[ 0,1].
Global stability of a distributed delayed viral model with general incidence rate
Authors: Ávila-Vales Eric , Canul-Pech Abraham , Rivero-Esquivel Erika 
Published: January 2019

AbstractIn this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria. By using the Lyapunov functional and LaSalle invariance principle, we obtained the conditions of global stabilities of the infection-free equilibrium, the immune-exhausted equilibrium and the endemic equilibrium. Numerical simulations are given to verify the analytical results.
Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis
Authors: Crown Anthony M , Roberts Brittany L , Crosby Keith , Brown Hilda , Ayers Jacob I , Hart P John , Borchelt David R 
Published: January 2019

AbstractMutations in more than 80 different positions in superoxide dismutase 1 (SOD1) have been associated with amyotrophic lateral sclerosis (fALS). There is substantial evidence that a common consequence of these mutations is to induce the protein to misfold and aggregate. How these mutations perturb native structure to heighten the propensity to misfold and aggregate is unclear. In the present study, we have mutagenized Glu residues at positions 40 and 133 that are involved in stabilizing the β-barrel structure of the native protein and a critical Zn binding domain, respectively, to examine how specific mutations may cause SOD1 misfolding and aggregation. Mutations associated with ALS as well as experimental mutations were introduced into these positions. We used an assay in which mutant SOD1 was fused to yellow fluorescent protein (SOD1:YFP) to visualize the formation of cytosolic inclusions by mutant SOD1. We then used existing structural data on SOD1, to predict how different mutations might alter local 3D conformation. Our findings reveal an association between mutant SOD1 aggregation and amino acid substitutions that are predicted to introduce steric strain, sometimes subtly, in the 3D conformation of the peptide backbone.
Improved Genome Sequence of Wild Emmer Wheat Zavitan with the Aid of Optical Maps
Authors: Zhu Tingting , Wang Le , Rodriguez Juan C , Deal Karin R , Avni Raz , Distelfeld Assaf , McGuire Patrick E , Dvorak Jan , Luo Ming-Cheng 
Published: January 2019

Abstract
Wild emmer (Triticum turgidum ssp. dicoccoides) is the progenitor of all modern cultivated tetraploid wheat. Its genome is large (&gt; 10 Gb) and contains over 80% repeated sequences. The successful whole-genome-shotgun assembly of the wild emmer (accession Zavitan) genome sequence (WEW_v1.0) was an important milestone for wheat genomics. In an effort to improve this assembly, an optical map of accession Zavitan was constructed using Bionano Direct Label and Stain (DLS) technology. The map spanned 10.4 Gb. This map and another map produced earlier by us with the Bionano’s Nick Label Repair and Stain (NLRS) technology were used to improve the current wild emmer assembly. The WEW_v1.0 assembly consisted of 151,912 scaffolds. Of them, 3,102 could be confidently aligned on the optical maps. Forty-seven were chimeric. They were disjoined and new scaffolds were assembled with the aid of the optical maps. The total number of scaffolds was reduced from 151,912 to 149,252 and N50 increased from 6.96 Mb to 72.63 Mb. Of the 149,252 scaffolds, 485 scaffolds, which accounted for 97% of the total genome length, were aligned and oriented on genetic maps, and new WEW_v2.0 pseudomolecules were constructed. The new pseudomolecules included 333 scaffolds (68.51 Mb) which were originally unassigned, 226 scaffolds (554.84 Mb) were placed into new locations, and 332 scaffolds (394.83 Mb) were re-oriented. The improved wild emmer genome assembly is an important resource for understanding genomic modification that occurred by domestication.
Mitotic Cell Division in Caenorhabditis elegans
Authors: Pintard Lionel , Bowerman Bruce 
Published: January 2019

Abstract
Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans. The C. elegans pathways tend to be streamlined, facilitating dissection of the more redundant human pathways. Here, we summarize the virtues of C. elegans as a model system and review our current understanding of centriole duplication, the acquisition of pericentriolar material by centrioles to form centrosomes, the assembly of kinetochores and the mitotic spindle, chromosome segregation, and cytokinesis.
PELUANG PENERAPAN KONSEP BLUE ECONOMY PADA USAHA PERIKANAN DI KABUPATEN LOMBOK TIMUR
Authors: Zamroni Achmad , Nurlaili Nurlaili , Witomo Cornelia Mirwantini 
Published: January 2019

Tantangan pengembangan ekonomi biru di Lombok adalah menurunnya habitat terutama rumput laut, terumbu karang dan bakau, karena tingginya tekanan ekonomi yang menyebabkan orang terlibat dalam eksploitasi sumber daya perikanan. Tujuan riset adalah mereview penerapan konsep “Ekonomi Biru” pada usaha perikanan budidaya di Kabupaten Lombok Timur. Data dan informasi dikumpulkan melalui penelusuran dokumen, laporan riset dan publikasi ilmiah terkait topik kajian. Dokumen-dokumen tersebut dianalisis secara konten (content analysis) dan direview dari aspek sosial dan ekonomiyang dijelaskan secara kualitatif. Hasil review menunjukkan bahwa 6 (enam) usaha perikanan dapat memberikan efek berganda yaitu budidaya lobster, budi daya rumput laut, pengolahan kepiting, pengolahan limbah kepala ikan, dan tambak garam mempunyai peluang menciptakan efek berganda, artinya keenam usaha tersebut dapat menciptakan alternatif mata pencaharian yang bisa berdampak pada peningkatan ekonomi rumah tanggaTitle: Prospects of the Implementation of Blue Economy Concept on An opportunity Fisheries Bussiness in East Lombok DistrictThe challenge of developing a blue economy in Lombok is the decline of habitats, especially seaweed, coral reefs and mangroves, due to the high economic pressure that causes people to be involved in exploitation of fisheries resources. The aim of the research is to review the application of the concept of “Blue Economy” in aquaculture businesses in East Lombok District. Data and information were collected through documents investigation, research reports and scientific publications related to the topic of the study. These documents were analyzed using content analysis and reviewed from the social and economic aspects qualitatively described. The result shows that the review indicates that 6 (six) fisheries businesses can provide multiple effects namely lobster aquaculture, seaweed farming, crab processing, fish head waste treatment, and salt farming have the opportunity to create multiple effects, meaning that the six businesses can create alternative livelihoods that can has an impact on improving the household economy
Celebración de San Alberto Magno 2011/ Congresos reuniones y otras actividades
Authors: Ciencias Biológicas y Ambientales Facultad 
Published: January 2019

Con motivo de la festividad de San Alberto Magno, patrono de la Facultad de Ciencias Biológicas y Ambientales (FCCBA), se desarrollaron entre los días 10 y 18 de noviembre diversas actividades y conferencias. Además en el presente artículo se desarrollan otras actividades entre las que destacan: las primeras "Jornadas de Biología Forense", jornadas "Y después ¿qué?", taller monográgico "Técnicas de bísqueda de empleo", "II Jornadas de orientación profesional", "Jornadas de Puertas Abiertas", "Jornadas de Biología Marina" así como la celebración del primer "Día Internacional de Fascinación por las Plantas".
Сompatibility of Systemic Drugs and Local Antihypertensive Therapy in Patients with Primary Open-Angle Glaucoma (Analytical Review)
Authors: Erichev V. P. , Makarova A. S. 
Published: January 2019

The review presents data of the most common comorbid diseases in patients with primary open-angle glaucoma, the features of local and general influence of antiglaucoma drugs, as well as information about the possible drug interactions of local antihypertensive and systemic medicines. Local antihypertensive drugs are often embedded in the daily patients regimen of systemic drugs use. Up to80 % of the active substances in ophthalmic drugs are absorbed systemically, while not subject to the primary stages of metabolism. Anti-glaucoma drugs can cause serious side effects: symptomatic bradycardia, various conduction disturbances in the heart muscle, orthostatic hypotension, syncope, dyspeptic symptoms, exacerbation of chronic diseases of the liver and kidneys, etc. In clinical studies, it was shown that the level of timolol in blood plasma correlates with the development of side effects from the cardiovascular system. In everyday ophthalmic practice, β-blockers are considered as drugs with a minimal number of adverse events, they are the most widely used in hypotensive glaucoma therapy. But another thing is also known: receptors for β-adrenergic blockers are present in almost all organs and tissues of the body. This circumstance determines the frequency, prevalence and nature of adverse events associated with β-blockers intake. with simultaneous systemic and topical application of β-blockers, mutual enhancement of effects is possible (additional IOP decrease and enhancement of β-adrenergic blocking effect on the cardiovascular system). If β₁-, β₂-adrenergic blockers and adrenergic psychotropic drugs should be used together with caution: the latter affect peripheral innervation, the α-adrenoblocking effect is most pronounced, resulting in a decrease in the strength of heart contractions, a drop in blood pressure until orthostatic hypotension develops. All mentioned above must be considered for choosing and prescribing antiglaucoma drugs. It increases compliance, patient’s quality of life and allows to stabilize the glaucomatous process.