bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombocytosis and thrombocytopenia are markers of poor outcome in pediatric patients with community-acquired pneumonia
Authors: Sun Huiming , Li Shuxiang , Zhu Canhong , Yan Yongdong , Wang Yuqing , Hao Chuangli , Chen Zhengrong , Ji Wei 
Published: May 2019

Abstract
Abstract
Background: This study aimed to investigate the prevalence of thrombocytopenia and thrombocytosis in hospitalized pediatric patients with community-acquired pneumonia (CAP), and determine whether thrombocytopenia and thrombocytosis are associated with patient outcome.
Methods: A total of 9,372 consecutive patients, who were 1-168 months old, diagnosed with CAP and admitted in the Children’s Hospital of Soochow University, were enrolled in the present retrospective observational study. Their clinical and laboratory data were collected. According to the platelet count on admission, these patients were divided into three groups: thrombocytopenia, normal platelet count, and thrombocytosis groups. The clinical characteristics and etiologic pathogens were compared among these groups. The multivariate logistic regression model was applied to identify risk factors for severe CAP, length of hospitalization ≥10 days and respiratory complications. The correlations between platelet count and clinical features were determined by Spearman’s correlation.
Results: Thrombocytosis and thrombocytopenia were found in 3,376 (36.0%) and 43 (0.5%) patients, respectively. Normal platelet count was observed in 5,953 (63.5%) patients. Thrombocytopenia was an independent risk factor of severe CAP (OR, 6.206; 95% CI, 2.209-17.436; P=0.001), while thrombocytosis was associated with length of hospitalization of ≥10 days (OR, 1.315; 95% CI, 1.177-1.470; P<0.001). In addition, thrombocytosis was associated with respiratory complications (OR, 1.658; 95% CI, 1.171-2.346; P=0.004). Platelet count (median 350.0 [IQR 270.2-447.0] × 109/L) was positively correlated with length of hospitalization (median 7.0 [IQR 6.0-9.0] days) (r = 0.101, P<0.001), but negatively correlated with age (median 12.0 [IQR 3.0-36.0] months) (r = -0.401, P<0.001) and C-reactive protein (median 2.0 [IQR 0.3-10.7] mg/dl) (r = -0.191, P<0.001).
Conclusion: Thrombocytosis is highly prevalent, while thrombocytopenia has low prevalence in pediatric CAP patients. Both thrombocytosis and thrombocytopenia are associated with clinical outcomes in pediatric CAP patients.
Genome-wide Sequence Analysis of Human Splice Acceptor Regions for Motif Discovery
Authors: Bahçe Gülşah Karaduman , SON YEŞİM AYDIN 
Published: May 2019

Abstract
Background
Splicing mechanism in eukaryotic cells, drives the protein diversity. This important mechanism is orchestrated by regulatory factors controlled through various splicing signals. 3’ and 5’ splice sites, and common branch point sequences are known as initiating signals of splicing, and changes in these signals can be the underlying cause of diseases. Nevertheless, an extensive genome-wide analysis of the sequences around these signals is lacking. In this study, we focused on the genome-wide motif analysis of splice acceptor region and analyzed 400 nucleotides long sequences (300 nucleotides upstream and 100 nucleotides downstream of 3’) to identify candidate motifs with functional importance.

Results
207,583 sequences retrieved from Ensembl Biomart are analyzed with MEME ChIP resulting in 518 significant splice acceptor region motifs. Besides 457 known motifs, 227 of which are observed on various mammalians other than Homo sapiens, 61 novel mammalian motifs are identified. Furthermore, proteins binding to the known motifs, are mainly annotated for homeobox, homeodomain, DNA binding region, and transcription regulation function. Additionally, 4 novel motifs, supported with experimental evidence from DNA binding studies, are identified as potential branch-site motifs.

Conclusions
Genome-wide computational motif analysis around the human acceptor region sequences identified significant splice acceptor region motifs. The known mammalian motifs, among the computationally significant acceptor region motifs, had known biological roles with prior experimental support. The novel acceptor region motifs identified for the first time in this study are proposed as candidate motifs, and studying their biological roles in functional studies will further increase our understanding of the splicing mechanisms.
Farmers as Researchers: In‐depth Interviews to Discern Participant Motivation and Impact
Authors: Thompson Laura J. , Glewen Keith L. , Elmore Roger W. , Rees Jennifer , Pokal Sayli , Hitt Brianna D. 
Published: May 2019

On‐farm research is a method for transferring technology to farmers, validating small plot research, generating new discovery, and evaluating field‐scale, site‐specific management techniques. Little has been done to understand what motivates farmers to participate in on‐farm research and what the impact of their participation is on their decision making and farm profitability. This study evaluated the University of Nebraska‐Lincoln's over 25 yr‐old on‐farm research program using a semi‐structured, in‐depth interview tool to complete interviews with a stratified sample of 40 of the 140 past‐participants. The focus of this qualitative study was obtaining rich descriptions of farmer participants to better understand motivation for involvement in an on‐farm research program, participant research experiences, and the economic impacts of an on‐farm research program. Quantitative statistical analyses of the qualitative data are included for informational purposes; however, our conclusions focus on the qualitative analysis. Farmers participated in an on‐farm research program for a variety of reasons, most commonly for economic gain. Positive experiences were largely credited to the interactions with university faculty and other farmers. The participating farmers’ perception regarding whether or not the project took too much time was unrelated to whether weigh wagons or yield monitors were used. Farmers were interested in many aspects of research, including project ideation, experimental design, and statistical analysis. Participating farmers’ satisfaction in their experience and implementation of research results was not dependent on the farmers independently generating their research topic. The most impassioned suggestion from the farmer research participants was to develop innovative research projects.Core Ideas

In‐depth interviews with participants in an on‐farm research program generated insights into motivation for participation and program impact.
Farmers participated in the program for a variety of reasons including economic gain, seeking answers to a specific questions, general curiosity, and a desire for reliable and unbiased research results.
Positive experiences in the on‐farm research program were largely credited to interactions with university faculty and other farmers.
The origin of the research topic or idea did not influence participant satisfaction in their experience or implementation of the results.
Seventy‐five percent of interviewees had put their research results into practice in their farm operation, either by making a change based on results or by not making a change as the research confirmed their current practice.
Demonstrating process robustness of potable reuse trains during challenge testing with elevated levels of acetone, formaldehyde, NDMA, and 1,4-dioxane
Authors: Tackaert Rodrigo A. , Pisarenko Aleksey N. , Chen Elise C. , Kolakovsky Aviv , Pecson Brian M. , Drewes Jörg E. , Rhodes Trussell R. , Shane Trussell R. 
Published: May 2019

Abstract
Robustness of a demonstration potable reuse facility was evaluated through a series of system-wide chemical challenge tests spiking neutral low-molecular weight compounds (acetone, formaldehyde, N-nitrosodimethylamine (NDMA), and 1,4-dioxane) which are known to be challenging for removal through advanced treatment. Two advanced treatment train arrangements were compared: O3/BAC-MF/UF-RO-AOP and RO-AOP. Ozone and biological activated carbon (O3/BAC) offered significant attenuation of the smallest and most biologically degradable compounds tested: acetone and formaldehyde. These two compounds had limited reduction across the reverse osmosis (RO) membrane barrier and the different advanced oxidation process (AOP) setups used. 1,4-Dioxane was partially reduced across the oxidation barriers: 62% across ozonation and up to 95% across AOP depending on oxidant used and oxidant dose. Both a hydrogen peroxide (H2O2) based AOP (UV/H2O2) and a sodium hypochlorite (as HOCl) based AOP (UV/HOCl) demonstrated sufficient oxidation, providing no less than 0.5-log (68%) 1,4-dioxane attenuation required by regulators in the USA. NDMA was reduced across both UV/H2O2 and UV/HOCl from 157 to 267 ng/L to below the 10 ng/L established notification level for drinking water in California. Overall, addition of O3/BAC enhanced cumulative removal of all the spiked trace organic chemicals, providing greater protection against the spiked contaminants than RO-AOP alone. In addition, online total organic carbon (TOC) monitoring successfully captured the presence of the spiked chemicals.
Case study of sulfide generation and emission in sanitary sewer with drop structures and pump station
Authors: Yang Zhi , Zhu David Z. , Yu Tong , Edwini-Bonsu Stephen , Liu Yanchen 
Published: May 2019

Abstract
Field work was carried out to identify sewer odor hotspots and corresponding causes in a sanitary sewer trunk with drop structures and pump station in Steinhauer area, Edmonton, Canada. Relatively high concentrations of H2S were detected at the beginning and the end of the trunk with odor complaints. At the beginning of the trunk, sulfide emission was mainly caused by the increased stripping effect of the drop structures. The pump operation at the end of the trunk causes the long retention time of the sewage and the subsequent sulfide generation. The sulfide generation was modeled and calibrated using field measurements. The model was applied to assess mitigation strategies, and optimized pump operation was found to be able to reduce sulfide generation in the study trunk sewer.
5-Hydroxymethylfurfural (HMF) in Organic Synthesis: A Review of its Recent Applications Towards Fine Chemicals
Authors: Fan Weigang , Verrier Charlie , Queneau Yves , Popowycz Florence 
Published: May 2019

Background:5-Hydroxymethylfurfural (5-HMF) is a biomass-derived platform chemical, which can be produced from carbohydrates. In the past decades, 5- HMF has received tremendous attention because of its wide applications in the production of various value-added chemicals, materials and biofuels. The manufacture and the catalytic conversion of 5-HMF to simple industrially-important bulk chemicals have been well reviewed. However, employing 5-HMF as a building block in organic synthesis has never been summarized exclusively, despite the rapid development in this area.Objective:The aim of this review is to bring a fresh perspective on the use of 5-HMF in organic synthesis, to the exclusion of already well documented conversion of 5-HMF towards relatively simple molecules such as 2,5-furandicarboxylic acid, 2,5-dimethylfuran and so on notably used as monomers or biofuels.Conclusion:As it has been shown throughout this review, 5-HMF has been the object of numerous studies on its use in fine chemical synthesis. Thanks to the presence of different functional groups on this platform chemical, it proved to be an excellent starting material for the preparation of various fine chemicals. The use of this C-6 synthon in novel synthetic routes is appealing, as it allows the incorporation of renewable carbonsources into the final targets.
Primary Cardiac Tumors: A Retrospective Study
Authors: Mlika Mona , Daoud Nouha , Braham Emna , Marghli Adel , El Mezni Faouzi 
Published: May 2019

Objectives:Primary cardiac tumors are rare and account for 0.001 to 0.03% of cardiac lesions. The authors aim to describe the clinical, the microscopic and the therapeutic characteristics of these tumors through a 13-year-experience in order to highlight the diagnostic challenges faced.Methods:We report 10 primary cardiac tumors diagnosed in the Departments of Pathology and Thoracic Surgery of the same hospital through a 13-year-period.Results:Our study was conducted on 7 women and 3 men. The mean age of the patients was 54.22 years (average, 12 to 79 years). Dyspnea represented the most frequent symptom. Physical examination was normal in all patients. Trans-thoracic ultra-sound examination was performed in all patients. Cardiac MRI allowed localizing the tumors in 2 patients. They were located into the left auricle (6 cases), the right auricle (1 case) and the pericardium (3 cases). The microscopic examination was concluded to myxoma (7 cases), haemangioma (2 cases) and hemangioendothelioma (1 case). Surgical resection was possible in 9 patients. It was impossible in the case of hemangioendothelioma because of the adherence. One death was recorded secondary to postoperative arrhythmia. The other patients presented no complications after a follow-up period ranging from 2 months to 5 years.Conclusion:Cardiac tumors are challenging in their diagnosis and management. A positive diagnosis is based on microscopic examination. Surgical treatment plays a key role and is possible in the majority of benign tumors. The prognosis of malignant tumors remains poor even if a complete surgical resection is possible.
Fuzzy Control Algorithm for Estimation and Interaction of Dynamic Arm Motion
Authors: Al-Sharqi Mais A. , Hasan Haitham S. 
Published: May 2019

Background:
Significant work has been conducted in the direction of an intelligent interface
development through Human-Computer Interaction (HCI). Various forms of information, such
as video, audio, or in the written form, have been proposed either separately or in combination.

Methods:
This paper proposes an interactive contact solution based on the distinct characteristics of
contract distribution and the spatial and temporal consistency to establish a multiple display system.

Results:
The correspondence between the user’s arm position information and the virtual scene was
established by utilizing a virtual 3D interactive rectangular parallelepiped. An estimation technique
of the arm motion was designed, in conjunction with the employment of the Fuzzy Predictive Control
Mamdani Algorithm (FPCMA) using Robust Tracking (RT) for the user’s arm position and for
validating the efficiency and accuracy, Kalman filter algorithm (VEA) was used to test the stability.

Conclusion:
For RT, using FPCMA is 1.21 for 17fps while 0.83 for 35fps. For the output, the VEA
accuracy rate is 0.97.
Using Computer Games to Support Mental Health Interventions: Naturalistic Deployment Study
Authors: van der Meulen Hidde , McCashin Darragh , O'Reilly Gary , Coyle David 
Published: May 2019

Background
Recent research has highlighted naturalistic uptake as a key barrier to maximizing the impact of mental health technologies. Although there is increasing evidence regarding the efficacy of digital interventions for mental health, as demonstrated through randomized controlled trials, there is also evidence that technologies do not succeed as expected when deployed in real-world settings.

Objective
This paper describes the naturalistic deployment of Pesky gNATs, a computer game designed to support cognitive behavioral therapy (CBT) for children experiencing anxiety or low mood. The objective of this deployment study was to identify how therapists use Pesky gNATs in real-world settings and to discover positive and negative factors. On the basis of this, we aimed to derive generalizable recommendations for the development of mental health technologies that can have greater impact in real-world settings.

Methods
Pesky gNATs has been made available through a not-for-profit organization. After 18 months of use, we collected usage and user experience data from therapists who used the game. Data were collected through an online survey and semistructured interviews addressing the expectations and experiences of both therapists and young people. Thematic analysis was used to identify key themes in the interview and survey data.

Results
A total of 21 therapists, who used Pesky gNATs with 95 young people, completed the online survey. Furthermore, 5 therapists participated in the follow-up interview. Confirming previous assessments, data suggest that the game can be helpful in delivering therapy and that young people generally liked the approach. Therapists shared diverse opinions regarding the young people for whom they deemed the game appropriate. The following 3 themes were identified: (1) stages of use, (2) impact on the delivery of therapy, and (3) customization. We discuss therapists’ reflections on the game with regard to their work practices and consider the question of customization, including the delicate balance of adaptable interaction versus the need for fidelity to a therapeutic model.

Conclusions
This study provides further evidence that therapeutic games can support the delivery of CBT for young people in real-world settings. It also shows that deployment studies can provide a valuable means of understanding how technologies integrate with the overall mental health ecosystem and become a part of therapists' toolbox. Variability in use should be expected in real-world settings. Effective training, support for therapist autonomy, careful consideration of different approaches to customization, the reporting of deployment data, and support for communities of practice can play an important role in supporting variable, but effective, use.
Colonial Corporate Social Responsibility: Company Healthcare in Java, East Sumatra and Belitung, 1910-1940
Authors: Ochsendorf Frank 
Published: May 2019

This article discusses the impact of investments by foreign firms in healthcare and hygienic measures on indigenous society in late-colonial Indonesia (1910-1940), focusing on three principal centers of foreign investment activity: Java, East Sumatra and the island of Belitung. Such facilities, although primarily intended for workers and their families, were sometimes accessible for members of indigenous society without contractual or family connection to the private company furnishing them. In rare cases, private companies invested directly in the welfare of local communities. The article concludes that the impact of the social investments on the state of health of indigenous communities was generally positive and a much-needed addition to scarcely available public healthcare. While such social investments can be regarded as examples of proto-corporate social responsibility strategies, the improvement of welfare was always a means through which the ultimate goal could be achieved: survival of the company and maximization of profits.
Real-world effectiveness of palonosetron-based antiemetic regimens: preventing chemotherapy-induced nausea and vomiting
Authors: Schwartzberg Lee S , Marks Stanley M , Gabrail Nashat Y , Geller Robert B , Kish Jonathan 
Published: May 2019

Aim:
To evaluate real-world effectiveness of guideline-recommended palonosetron-containing antiemetic regimens in patients receiving highly (HEC) or moderately emetogenic (MEC) chemotherapy.
Patients & methods:
This retrospective analysis used records of adults receiving first-line chemotherapy and a three-drug palonosetron-containing antiemetic regimen for HEC or palonosetron-containing antiemetic regimen for MEC (carboplatin).
Results:
A total of 1587 records were evaluated. For HEC and MEC, respectively, chemotherapy-induced nausea and vomiting (CINV) occurred in 40 versus 44% of patient cycles (p = 0.01), and unscheduled iv. antiemetics in 41 versus 35% (p < 0.05). A total of 48% of HEC patients versus 42% of MEC patients had CINV-related clinic visits (p = 0.05).
Conclusion:
Palonosetron-containing antiemetic regimens may provide insufficient CINV control. Alternative regimens may improve patient quality of life and reduce healthcare resource utilization.
THE CORRELATION BETWEEN STRESSOR AND WORK ACHIEVEMENT THROUGH WORK STRESS ON THE EMPLOYEES IN THE MARKETING DIVISION OF SINAR JAYA MULTIPURPOSE COOPERATIVE MALANG
Authors: Wibowo Heri 
Published: May 2019

This study aimed at investigating the correlation between stressor and work stress, stressor and work achiavement, work stress and work achievement, and stressor and work achievement through work stress on the employees in the marketing division of Sinar Jaya cooperative, Malang. This descriptive-quantitative study employed mathemathical methods in describing the phenomena, while scale analysis method was used to describe the levels of the employees’ stressor, work stress, and work achiavement. Inaddition, the path analysis was used in testing the coutribution that was indicated by the path coefficient between the employees’ stressor, work stress, and work achievement variables. The average result of the scale analysis revealed that the stressor, work stress, and work achievement variables were considered high. Furthermore, the result of the path analysis also showed a significant correlation between stressor and work achievement through work stress. Keyword : Marketing Employees, Stressor, Work Stress, Work Achivement
PENGARUH PRODUK, HARGA, PROMOSI, SALURAN DISTRIBUSI, DAN PROSES TERHADAP KEPUTUSAN BRAND SWITCHING PADA KARTU TELEPON SELULER
Authors: Adzim Faudzul 
Published: May 2019

The research purposes are to analyses the effect of product, price, promotion, place, and process on brand switching decisions, and to determine dominant effect of those on brand switching decisions. Logistic regression of analysis was used as statistical analyses. The result showed that product, price, promotion, place, and process have a positive effect on brand switching decisions. Variable process has a dominant effect on brand switching decisions. The suggestions from this resesarch that the company should have many efforts to provide guarantee to satisfied customers by offering qualified product, giving gift or bonuses and decreasing the mobile card price. Keyword: Product, Price, Promotion, Place, Process, Brand Switching, Mobile Card.
PENGARUH FAKTOR-FAKTOR FUNDAMENTAL KE UANGAN TERHADAP HARGA SAHAM PERUSAHAAN PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BEI
Authors: Husnia Firda Silviyatul 
Published: May 2019

This study was conducted to determine the effect of factors such as financial fundamentals Earning Per Share (EPS), Return On Assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR) of the company and real property estate listed in Indonesia Stock Exchange during the period 2008-2013. The sampling technique used purposive sampling with a sample of five companies. Variables include the Earning Per Share (EPS), return on assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR) as the independent variable and stock price as dependent variables. Data were analyzed using descriptive statistical analysis and multiple linear regression analysis. The results of this study indicate that the simultaneous regression test (Test F), shows that the Earning Per Share (EPS), return on assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR ) simultaneously influence the stock prices of five companies that were visited. While partial regression test (t test) showed that the variable EPS, ROA, NPM and CR partial effect, whereas the variable DER has no partial effect on stock prices.