bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Language Influence on Second Language Offline and Online Ambiguous Pronoun Resolution
Authors: Schimke Sarah , de la Fuente Israel , Hemforth Barbara , Colonna Saveria 
Published: June 2018

AbstractThis study examined first language (L1) influence on second language (L2) ambiguous pronoun resolution by investigating (a) whether L1 influence takes place at the level of the pronominal form (form‐dependent influence) and/or at the level of the construction in which the form appears (construction‐dependent influence) and (b) whether effects differ in online compared to offline data. In Experiment 1, we replicated previously observed construction‐dependent crosslinguistic differences between French and German and provided new data for Spanish. In Experiment 2, we assessed offline and online interpretation preferences of intermediate L1 French and L1 Spanish learners of German. Our results provide evidence of form‐dependent L1 influence, in that learners transferred a generalized antecedent bias associated with overt pronouns. Moreover, our results extend previous findings by showing that L1 influence on L2 pronoun resolution can occur during online processing.Open PracticesThis article has been awarded Open Materials and Open Data badges. All materials and data are publicly accessible via the IRIS Repository at https://www.iris-database.org/iris/app/home/detail?id=york:934337. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Carbonaceous and noncarbonaceous iron meteorites: Differences in chemical, physical, and collective properties
Authors: Rubin Alan E. 
Published: June 2018

AbstractIron‐meteorite groups that appear from published isotopic data to have been derived from melted carbonaceous‐chondrite‐like precursors (CC irons) (IIC, IID, IIF, IIIF, IVB) tend to have higher median refractory siderophile element (RSE) contents, higher median Ni contents, and higher median Ir/Ni and Ir/Au ratios than magmatic noncarbonaceous (NC) iron‐meteorite groups (IC, IIAB, IIIAB, IIIE, IVA). (Group IIG is also NC.) One potential source of RSEs in magmatic CC irons is the set of refractory metal nuggets from inherited CAIs. Magmatic CC‐iron groups tend to have longer cosmic‐ray exposure (CRE) ages than magmatic NC‐iron groups, indicating long residence times as small bodies in interplanetary space. The lower membership of CC‐iron groups is probably mainly due to the high oxidation state of their precursors. Such oxidation would have produced lesser amounts of free metal; parent body differentiation of such bodies would have produced smaller cores, resulting in fewer samples available to make CC‐iron meteorites in the first place. (Ungrouped magmatic irons, most of which can be considered groups with only one member, also tend to be carbonaceous.) It is possible that a subset of the chondrule‐poor dark inclusions in many carbonaceous chondrites represent unmelted materials related to the precursors of the CC irons. The Eagle Station pallasites (also CC‐related) are analogous to CC irons in being more oxidized, richer in Ni and RSEs, and fewer in number than main‐group pallasites (PMG). However, Eagle Station has a shorter CRE age than most PMG.
Neon isotopes in individual presolar low‐density graphite grains from the Orgueil meteorite
Authors: Heck Philipp R. , Jadhav Manavi , Meier Matthias M. M. , Maruoka Teruyuki , Amari Sachiko , Zinner Ernst K. , Busemann Henner , Maden Colin , Gyngard Frank , Baur Heinrich , Wieler Rainer 
Published: June 2018

AbstractWe present He and Ne isotopes of individual presolar graphite grains from a low‐density separate from Orgueil. Two grain mounts were analyzed with the same techniques but in a different sequence: The first one was measured with NanoSIMS followed by noble gas mass spectrometry, and the second one in reverse order. No grain contained 4He and only one grain on the second mount contained 3He. On the first mount, the grains had been extensively sputtered with NanoSIMS ion beams prior to noble gas analysis; we found only one grain out of 15 with presolar 22Ne above detection limit. In contrast, we found presolar 22Ne in six out of seven grains on the second mount that was not exposed to an ion beam prior to noble gas analysis. All 22 grains on the two mounts were imaged with scanning electron microscopy (SEM) and/or Auger microscopy. We present evidence that this contrasting observation is most likely due to e‐beam–induced heating of the generally smaller grains on the first mount during SEM and Auger imaging, and not primarily due to the NanoSIMS analysis. If thermal contact of the grains to the substrate is absent, such that heat can only be dissipated via radiation, then the smaller, sputter‐eroded grains are heated to higher temperatures such that noble gases can diffuse out. We discuss possible gas loss mechanisms and suggest solutions to reduce heating during e‐beam analyses by minimizing voltages, beam currents, and dwell times. We also found small amounts of 21Ne in five grains. Using isotope data we determined that the dominant sources of most grains are core‐collapse supernovae, congruent with earlier studies of low‐density presolar graphite from Murchison. Only two of the grains are most likely from AGB stars, and two others have an ambiguous origin.
Impact‐induced chemical fractionation as inferred from hypervelocity impact experiments with silicate projectiles and metallic targets
Authors: Ganino Clément , Libourel Guy , Nakamura Akiko M. , Jacomet Suzanne , Tottereau Olivier , Michel Patrick 
Published: June 2018

AbstractHypervelocity impacts are common in the solar system, in particular during its early phases when primitive bodies of contrasted composition collided. Whether these objects are chemically modified during the impact process, and by what kind of processes, e.g., chemical mixing or gas–liquid–solid fractionation, are still pending questions. To address these issues, a set of impact experiments involving a multielemental doped phonolitic projectile and a metallic target was performed in a 3–7 km s−1 range of impact speeds which are typical of those occurring in the asteroid belt. For each run, both texture and chemistry of the crater and the ejecta population have been characterized. The results show that the melted projectiles largely cover the craters at all speeds, and that melted phonolitic materials are injected into fractures in the crater in the metallic target. Ejecta are generally quenched droplets of silicate impact melt containing metal beads. Some of these beads are extracted from the target, but we propose that some of the Fe metal beads are the result of reduction of FeO. A thin FeO‐SiO2‐rich condensate layer is found at the edge of the crater, suggesting that a limited amount of vapor formed and condensed. LA‐ICP‐MS analyses suggest, however, that within analytical uncertainties, no volatility‐controlled chemical fractionation of trace elements occurred in the ejecta. The main chemical fractionation during impact at such velocities and energies are the result of projectile‐target mixing.
Sm‐p80‐based vaccine trial in baboons: efficacy when mimicking natural conditions of chronic disease, praziquantel therapy, immunization, and Schistosoma mansoni re‐encounter
Authors: Siddiqui Arif J. , Molehin Adebayo J. , Zhang Weidong , Ganapathy Pramodh K. , Kim Eunjee , Rojo Juan U. , Redman Whitni K. , Sennoune Souad R. , Sudduth Justin , Freeborn Jasmin , Hunter Derick , Kottapalli Kameswara R. , Kottapalli Pratibha , Wettashinghe Ruwanthi , van Dam Govert J. , Corstjens Paul L.A.M. , Papin James F. , Carey David , Torben Workineh , Ahmad Gul , Siddiqui Afzal A. 
Published: June 2018

AbstractSm‐p80‐based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study was designed to replicate a human vaccine implementation scenario for endemic regions in which vaccine would be administered following drug treatment of infected individuals. In our study, the Sm‐p80‐based vaccine reduced principal pathology producing hepatic egg burdens by 38.0% and egg load in small and large intestines by 72.2% and 49.4%, respectively, in baboons. Notably, hatching rates of eggs recovered from liver and small and large intestine of vaccinated animals were significantly reduced, by 60.4%, 48.6%, and 82.3%, respectively. Observed reduction in egg maturation/hatching rates was supported by immunofluorescence and confocal microscopy showing unique differences in Sm‐p80 expression in worms of both sexes and matured eggs. Vaccinated baboons had a 64.5% reduction in urine schistosome circulating anodic antigen, a parameter that reflects worm numbers/health status in infected hosts. Preliminary analyses of RNA sequencing revealed unique genes and canonical pathways associated with establishment of chronic disease, praziquantel‐mediated parasite killing, and Sm‐p80‐mediated protection in vaccinated baboons. Overall, our study demonstrated efficacy of the Sm‐p80 vaccine and provides insight into some of the epistatic interactions associated with protection.
I am insured but how do I use my coverage: Lessons from the front lines of Medicaid reform
Authors: McCullough Kimberly , Dalstrom Matthew 
Published: June 2018

AbstractObjectiveWhen Illinois expanded Medicaid in 2014, the state also passed legislation requiring that 50% of Medicaid recipients be enrolled in a managed care plan. The purpose of this project was to identify the barriers and facilitators that Medicaid enrollees have understanding and using their managed care plans.Design and SampleIn this descriptive study, participants included Medicaid enrollees, community workers, health care navigators, and a state health insurance representative.MeasuresMethods included focus groups, interviews, and surveys.ResultsThe challenges that Medicaid enrollees had transitioning from a state administered Medicaid program to private managed care program were grouped into three general themes: Individual Barriers, Structural Barriers, and Questions about Medicaid.ConclusionThe Medicaid expansion in Illinois increased the number of people who receive health insurance. However, participants faced significant barriers using and understanding managed care because of their lack of previous experience using health insurance and the limited support provided by the state.
Men and masculinity in men's magazines: A review
Authors: Waling Andrea , Duncan Duane , Angelides Steven , Dowsett Gary W. 
Published: June 2018

AbstractThis review article provides a thematic synthesis and overview of 30 years of research into the study of men and masculinity in men's magazines. Over 100 articles, book chapters, and books were reviewed to explore how scholars have approached the study of masculinity in such magazines and identify four major areas of inquiry: the commodification of masculinity; the relationship between sexism and misogyny in men's magazines and men's attitudes towards women; the vulnerability of men to, and the role of magazines in the construction of, men's body image anxieties; and the increasing sexualisation of men's bodies. The strengths and potential limitations of these four thematic approaches are identified, including an insufficiently nuanced account of the ways in which men might actually engage with images and ideas about masculinity in such magazines; an overly singular view of male sexuality that naturalises sexist and predatory behaviour; and an overemphasis on men's bodies as sites of vulnerability, risk, or crisis at the expense of more substantive considerations of the relationship between the representation of body modification practices and technologies, and men's embodied identities. The review concludes with an overview of the present field and some suggestions for future research.
Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases
Authors: Gritsunov Artyom , Peek James , Diaz Caballero Julio , Guttman David , Christendat Dinesh 
Published: June 2018

SummaryQuinate is produced and used by many plants in the biosynthesis of chlorogenic acids (CGAs). Chlorogenic acids are astringent and serve to deter herbivory. They also function as antifungal agents and have potent antioxidant properties. Quinate is produced at a branch point of shikimate biosynthesis by the enzyme quinate dehydrogenase (QDH). However, little information exists on the identity and biochemical properties of plant QDHs. In this study, we utilized structural and bioinformatics approaches to establish a QDH‐specific primary sequence motif. Using this motif, we identified QDHs from diverse plants and confirmed their activity by recombinant protein production and kinetic assays. Through a detailed phylogenetic analysis, we show that plant QDHs arose directly from bifunctional dehydroquinate dehydratase–shikimate dehydrogenases (DHQD‐SDHs) through different convergent evolutionary events, illustrated by our findings that eudicot and conifer QDHs arose early in vascular plant evolution whereas Brassicaceae QDHs emerged later. This process of recurrent evolution of QDH is further demonstrated by the fact that this family of proteins independently evolved NAD+ and NADP+ specificity in eudicots. The acquisition of QDH activity by these proteins was accompanied by the inactivation or functional evolution of the DHQD domain, as verified by enzyme activity assays and as reflected in the loss of key DHQD active site residues. The implications of QDH activity and evolution are discussed in terms of plant growth and development.
High-Throughput Screening of Type III Secretion Determinants Reveals a Major Chaperone-Independent Pathway
Authors: Ernst Nadja Heinz , Reeves Analise Z. , Ramseyer Julia E. , Lesser Cammie F. 
Published: June 2018

ABSTRACT

Numerous Gram-negative bacterial pathogens utilize type III secretion systems (T3SSs) to inject tens of effector proteins directly into the cytosol of host cells. Through interactions with cognate chaperones, type III effectors are defined and recruited to the sorting platform, a cytoplasmic component of these membrane-embedded nanomachines. However, notably, a comprehensive review of the literature reveals that the secretion of most type III effectors has not yet been linked to a chaperone, raising questions regarding the existence of unknown chaperones as well as the universality of chaperones in effector secretion. Here, we describe the development of the first high-throughput type III secretion (T3S) assay, a semiautomated solid-plate-based assay, which enables the side-by-side comparison of secretion of over 20
Shigella
effectors under a multitude of conditions. Strikingly, we found that the majority of
Shigella
effectors are secreted at equivalent levels by wild-type and variants of
Shigella
that no longer encode one or all known
Shigella
T3S effector chaperones. In addition, we found that
Shigella
effectors are efficiently secreted from a laboratory strain of
Escherichia coli
expressing the core
Shigella
type III secretion apparatus (T3SA) but no other
Shigella
-
specific proteins. Furthermore, we observed that the sequences necessary and sufficient to define chaperone-dependent and -independent effectors are fundamentally different. Together, these findings support the existence of a major, previously unrecognized, noncanonical chaperone-independent secretion pathway that is likely common to many T3SSs.

IMPORTANCE
Many bacterial pathogens use specialized nanomachines, including type III secretion systems, to directly inject virulence proteins (effectors) into host cells. Here, we present the first extensive analysis of chaperone dependence in the process of type III effector secretion, providing strong evidence for the existence of a previously unrecognized chaperone-independent pathway. This noncanonical pathway is likely common to many bacteria, as an extensive review of the literature reveals that the secretion of multiple type III effectors has not yet been knowingly linked to a chaperone. While additional studies will be required to discern the molecular details of this pathway, its prevalence suggests that it can likely serve as a new target for the development of antimicrobial agents.
The Efficacy of Direct Mail, Patient Navigation, and Incentives for Increasing Mammography and Colonoscopy in the Medicaid Population: A Randomized Controlled Trial
Authors: Slater Jonathan S. , Parks Michael J. , Nelson Christina L. , Hughes Kelly D. 
Published: June 2018

Abstract
Background: Despite lower cancer screening rates and survival rates in the Medicaid population compared with those with private insurance, there is a dearth of population-based, evidence-based interventions targeting Medicaid clients to address this problem.
Methods: This study reports results of a population-based randomized controlled trial (RCT) among all individuals enrolled in Minnesota's Medicaid program who were overdue for breast cancer (n = 22,113) and/or colorectal cancer (n = 94,294) screening. Individuals were randomized to intervention or control groups. The intervention group received persuasive and innovative direct mail materials coupled with a $20 incentive for using their Medicaid benefit to get screened. Direct mail materials provided a phone number to a call center staffed by patient navigators who addressed barriers and scheduled appointments via three-way calls. The control group received the intervention 15 months later. Primary outcomes were completion of mammography or colonoscopy within 12 weeks of the intervention. Billing claims served as evidence of screening.
Results: Multivariate logistic regression showed significant differences for both breast cancer (P &lt; 0.001) and colorectal cancer (P &lt; 0.01). The odds of receiving a mammogram for the treatment group were significantly higher than the control group [OR = 1.30; 95% confidence interval (95% CI) = 1.16–1.46], and the treatment group was more likely to receive a colonoscopy than the control group (OR = 1.12; 95% CI = 1.04–1.21).
Conclusions: This population-based intervention increased breast cancer and colorectal cancer screening in a Medicaid population overdue for screening.
Impact: These findings may have broad application for reaching individuals who generally remain outside the health care system despite having public health insurance. Cancer Epidemiol Biomarkers Prev; 27(9); 1047–56. ©2018 AACR.
AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells
Authors: Verma Kshitij , Gupta Nehal , Zang Tianzhu , Wangtrakluldee Phumvadee , Srivastava Sanjay K. , Penning Trevor M. , Trippier Paul C. 
Published: June 2018

Abstract
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherapeutic failure. Significant upregulation of AKR1C3 is observed in CRPC patient samples and derived CRPC cell lines. As AKR1C3 is a downstream steroidogenic enzyme synthesizing intratumoral testosterone (T) and 5α-dihydrotestosterone (DHT), the enzyme represents a promising therapeutic target to manage CRPC and combat the emergence of resistance to clinically employed androgen deprivation therapy. Herein, we demonstrate the antineoplastic activity of a potent, isoform-selective and hydrolytically stable AKR1C3 inhibitor (E)-3-(4-(3-methylbut-2-en-1-yl)-3-(3-phenylpropanamido)phenyl)acrylic acid (KV-37), which reduces prostate cancer cell growth in vitro and in vivo and sensitizes CRPC cell lines (22Rv1 and LNCaP1C3) toward the antitumor effects of enzalutamide. Crucially, KV-37 does not induce toxicity in nonmalignant WPMY-1 prostate cells nor does it induce weight loss in mouse xenografts. Moreover, KV-37 reduces androgen receptor (AR) transactivation and prostate-specific antigen expression levels in CRPC cell lines indicative of a therapeutic effect in prostate cancer. Combination studies of KV-37 with enzalutamide reveal a very high degree of synergistic drug interaction that induces significant reduction in prostate cancer cell viability via apoptosis, resulting in &gt;200-fold potentiation of enzalutamide action in drug-resistant 22Rv1 cells. These results demonstrate a promising therapeutic strategy for the treatment of drug-resistant CRPC that invariably develops in prostate cancer patients following initial treatment with AR antagonists such as enzalutamide. Mol Cancer Ther; 17(9); 1833–45. ©2018 AACR.
The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression
Authors: Wallez Yann , Dunlop Charles R. , Johnson Timothy Isaac , Koh Siang-Boon , Fornari Chiara , Yates James W.T. , Bernaldo de Quirós Fernández Sandra , Lau Alan , Richards Frances M. , Jodrell Duncan I. 
Published: June 2018

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor efficacy. Ataxia telangiectasia and Rad3-related protein (ATR), the apical kinase of the intra–S-phase DNA damage response, plays a central role in safeguarding cells from replication stress and can therefore limit the efficacy of antimetabolite drug therapies. We investigated the ability of the ATR inhibitor, AZD6738, to prevent the gemcitabine-induced intra–S-phase checkpoint activation and evaluated the antitumor potential of this combination in vitro and in vivo. In PDAC cell lines, AZD6738 inhibited gemcitabine-induced Chk1 activation, prevented cell-cycle arrest, and restrained RRM2 accumulation, leading to the strong induction of replication stress markers only with the combination. Moreover, synergistic growth inhibition was identified in a panel of 5 mouse and 7 human PDAC cell lines using both Bliss Independence and Loewe models. In clonogenic assays, the combination abrogated survival at concentrations for which single agents had minor effects. In vivo, AZD6738 in combination with gemcitabine was well tolerated and induced tumor regression in a subcutaneous allograft model of a KrasG12D; Trp53R172H; Pdx-Cre (KPC) mouse cancer cell line, significantly extending survival. Remarkably, the combination also induced regression of a subgroup of KPC autochthonous tumors, which generally do not respond well to conventional chemotherapy. Altogether, our data suggest that AZD6738 in combination with gemcitabine merits evaluation in a clinical trial in patients with PDAC. Mol Cancer Ther; 17(8); 1670–82. ©2018 AACR.