bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica
Authors: Mahjoubi Linda , Cecchi Fabiola , Massard Christophe , Calabro Fabio , Gazzah Anas , Bahleda Rastislav , Jamme Philippe , Gelli Maximiliano , Goere Diane , Lacroix Ludovic , Adam Julien , Heukamp Lukas , Trenta Patrizia , Hembrough Todd , Soria Jean-Charles , Sternberg Cora , Ducreux Michel 
Published: March 2018

Introduction: Diffuse gastric cancer is associated with poor prognosis. We report a patient with metastatic gastric linitis plastica harboring human epidermal growth factor receptor 2 ( HER2) activating mutation and HER2 amplification. Case description: The patient received 5-fluorouracil/folinic acid and oxaliplatin combined with trastuzumab/pertuzumab, resulting in disease control for 8 months. Second-line therapy with nivolumab and trastuzumab/pertuzumab was well-tolerated, with macroscopic peritoneal response. Following ovarian progression and surgical resection of ovarian metastases, immunohistochemistry of PD-L1 was negative; proteomics demonstrated normal expression of HER2 and absence of PD-L1, while genomics showed HER2 amplification, suggesting mechanisms of escape to dual HER2 blockade by downregulation of HER2 and to nivolumab by the absence of PD-L1. Based upon this and nonexpression of biomarkers of taxane resistance, therapy was changed to paclitaxel. Two and a half years after diagnosis, the patient is undergoing treatment, with excellent performance status. Conclusions: Molecular analysis and personalized therapy can help optimize treatment in difficult-to-treat cancers.
Older adults’ experiences and expectations after discharge from home-based occupational therapy
Authors: Nielsen Tove Lise , Bjerrum Merete , Nielsen Claus Vinther , Petersen Kirsten Schultz 
Published: March 2018

Introduction Home-based occupational therapy can improve older adults’ occupational performance, but maintaining improvements presents challenges, and service development is needed. In this study, older adults’ experiences and expectations concerning their occupational performance after discharge from home-based occupational therapy were examined and used to develop suggestions for improved practice. Method Semi-structured qualitative interviews were conducted with 11 older adults living alone or with a spouse. The interviews were analysed using inductive qualitative content analysis. Findings The older adults still strove to improve and maintain their occupational performance using various strategies; their desire for independence was strong, but some could accept a lesser degree of independence. Conclusion From the findings and existing literature, ideas were developed to improve home-based occupational therapy and support maintenance of occupational performance after discharge. These ideas include: (a) finding strategies to achieve satisfactory occupational performance that does not necessarily entail full independence, (b) increased focus on the use and transfer of problem-solving strategies, (c) acknowledging and addressing possible reluctance to use assistive devices, and (d) individually scheduled follow-up visits post occupational therapy. Future research should examine the effectiveness and applicability of these ideas.
Assessment and Management of Psychosocial Needs
Authors: Kaye Alison , Lybrand Sandra , Chew William L. 
Published: March 2018

Objective: To determine family-reported psychosocial stressors and social worker assessments and interventions within a comprehensive cleft team. Design: Single-institution prospective provider-completed survey. Patients: Four hundred one families seen by cleft team social worker over a 7-month period. Results: Most families (n = 331; 83%) participated in the team social work assessment. At least 1 active psychosocial stressor was reported by 238 (72%) families, with 63 (19%) families reported 3 or more stressors. There were 34 types of stressors reported. Most common were financial strain, young age of patient, new cleft diagnosis, and distance from clinic (57% of families live over an hour away). Family structure and home environment were assessed in detail for 288 (87%) families. Detailed assessments for access to care and behavioral/developmental issues also figured prominently. Social work interventions were provided in 264 (80%) of the visits, of which 91 were for families of new patients with over half who had infants less than 3 months old. Of the 643 interventions provided, the most frequent were parent mental health screens and counseling, early intervention referrals, transportation assistance, securing local hotel discounts, orthodontic referrals, and orthodontic cost coverage. Approximately 10% of encounters required follow-up contact related to the psychosocial concerns identified in clinic. Conclusions: The inclusion of a cleft team social worker is a critical component of comprehensive cleft team care as evidenced by the large proportion of families who required assistance. Ongoing social work assessments are recommended for each patient to help address the variety of psychosocial stressors families face.
Voice Quality in Adults Treated for Unilateral Cleft Lip and Palate
Authors: Morén Staffan , Lindestad Per Åke , Holmström Mats , Mani Maria 
Published: March 2018

Objectives: The aim of the current study was to assess voice quality among adults treated for unilateral cleft lip and palate (UCLP), after one- or two-stage palate closure, and compare it to a noncleft control group. Study Design: Cross-sectional study of patients with UCLP with long-term follow-up and noncleft controls. Participants: Patients with UCLP born between 1960 and 1987, treated at Uppsala University Hospital, Sweden, were examined (n = 73) at a mean of 35 years after primary surgery. Forty-seven (64%) patients had been treated with 1-stage palate closure and 26 with 2-stage closure (36%). The noncleft control group consisted of 63 age-matched volunteers. Main Outcome Measures: Ratings of perceptual voice characteristics from blinded voice recordings with Swedish Voice Evaluation Approach method. Acoustic voice analysis including pitch and spectral measures. Results: Among the patients, the mean values for the 12 evaluated variables on a visual analog scale (0 = no abnormality, 100 = maximal abnormality) ranged between 0.1 and 17, and the mean for all was 6 mm. Voice variables were similar between patients and controls, except the total mean of all the perceptual voice variables, as well as “vocal fry”; both slightly lower among patients ( P = .018 and P = .009). There was no difference in any variable between patients treated with 1-stage and 2-stage palate closure. No clear relationship was found between velopharyngeal insufficiency and dysphonia. Conclusions: The voice characteristics among adults treated for UCLP in childhood are not different from those of individuals without cleft.
Insertion site assessment of peripherally inserted central catheters: Inter-observer agreement between nurses and inpatients
Authors: Webster Joan , Northfield Sarah , Larsen Emily N , Marsh Nicole , Rickard Claire M , Chan Raymond J 
Published: March 2018

Introduction: Many patients are discharged from hospital with a peripherally inserted central catheter in place. Monitoring the peripherally inserted central catheter insertion site for clinical and research purposes is important for identifying complications, but the extent to which patients can reliably report the condition of their catheter insertion site is uncertain. The aim of this study was to assess the inter-observer agreement between nurses and patients when assessing a peripherally inserted central catheter site. Methods: The study was based on inpatients who were enrolled in a single-centre, randomised controlled trial comparing four different dressing and securement devices for peripherally inserted central catheter sites. A seven-item peripherally inserted central catheter site assessment tool, containing questions about the condition of the dressing and the insertion site, was developed. Assessment was conducted once by the research nurse and, within a few minutes, independently by the patient. Proportions of agreement and Cohen’s kappa were calculated. Results: In total, 73 patients agreed to participate. Overall, percentage agreement ranged from 83% to 100% (kappa = .65–.82). For important clinical signs (redness, swelling, ooze, pus and tracking), there were high levels of percentage agreement (99%–100%). Conclusion: The high level of agreement between nurse/patient pairs make the instrument useful for assessing peripherally inserted central catheter–associated signs of localised infection, allergic or irritant dermatitis or dressing dislodgement in a community setting.
Effect of catheter diameter on left innominate vein in breast cancer patients after totally implantable venous access port placement
Authors: Song Myung Gyu , Seo Tae-Seok , Kim Yun Hwan , Cho Sung Bum , Chung Hwan Hoon , Lee Seung Hwa , Jung Euichul 
Published: March 2018

The effect of catheter diameter on left innominate vein stenosis in breast cancer patients after totally implantable venous access port placement. Purpose: To evaluate the effect of catheter diameter on left innominate vein stenosis in breast cancer patients after placement of totally implantable venous access ports. Materials and methods: Totally implantable venous access ports were placed via the left internal jugular vein in 241 women with right breast cancer from January 2010 to December 2014 (mean age, 51.5 years; range, 19–83 years). There were 67 totally implantable venous access ports with a 6.5F catheter and 142 totally implantable venous access ports with an 8F catheter. Medical records were retrospectively reviewed. The presence of significant left innominate vein stenosis and tip location of the catheter was evaluated on chest computed tomography images. Statistical analysis was performed. Results: Left innominate vein stenosis developed in 1 (1.5%) and 13 (9.2%) patients after implantation with 6.5 and 8F catheters, respectively. Difference in the cumulative incidence of left innominate vein stenosis was statistically significant between the two groups (log rank test p-value: 0.002). In Cox regression analysis, the hazard ratio for left innominate vein stenosis was 20.766 ( p = 0.005) for an 8F catheter. Conclusion: The incidence of left innominate vein stenosis was higher after implantation of totally implantable venous access ports with 8F catheter rather than with 6.5F catheter. Considering that using 8F catheter versus 6.5F catheter has no advantage in terms of performance of the device, the results of our study suggest that ports with catheters >7F should be avoided.
Factors Protecting Male and Female Adolescents in Mexico From Human Papillomavirus Infection
Authors: Gómez Claudia Orozco , Champion Jane Dimmitt , Monsiváis María Guadalupe Moreno 
Published: March 2018

Introduction: Adolescents may be infected with human papillomavirus (HPV) during their first sexual relationship. Persistent infections in adulthood may result in associated cancers among both women and men. This study explored condom use action plans, its influence on sexual activity in adolescents, and associated HPV protective behavior. Methods: A descriptive correlational design was used. A convenience sample including adolescents ( N =313; male n = 171, female n = 142), aged 15 to 17 years, attending one of three public high schools in Mexico was recruited. Self-report structured questionnaires were used to assess sociodemographics, sexual behavior, and HPV protective behavior. Findings: Self-reported HPV knowledge among Mexican adolescents was low. Adolescents ( n = 81, 25.9%) self-reported sexual experience. Comparisons of adolescents by self-reported sexual experience identified significant differences, including higher condom use self-efficacy, sexual rights knowledge, a condom use action plan, and greater interpersonal influence on HPV protective behavior among those who had sexual experience. Significant factors predicting HPV protective behavior included self-reported number of sexual partners, condom use in past 3 months, and having a condom use action plan. Conclusion: An intervention targeting adolescents should encourage adolescents to develop their own cognitive processes, thereby facilitating the adoption or development of action plans for HPV protective behavior.
A qualitative study of health professionals’ views on using iPads to facilitate distraction during paediatric burn dressing changes
Authors: Green Elizabeth , Cadogan Julia , Harcourt Diana 
Published: March 2018

Introduction: Distraction is a non-pharmacologic pain management technique commonly used to avert a person’s attention from procedural pain and distress during stressful procedures such as treatment after a burn injury. In recent years, computer tablets (such as iPads) have been used within paediatric burns services to facilitate distraction by way of apps, games, cartoons and videos during dressing changes. However, we know very little about health professionals’ experiences of using them in this context. Methods: The current study explored health professionals’ experiences of using iPads to facilitate distraction during paediatric burn dressing changes. Fifteen health professionals from a single paediatric burns unit were interviewed. Thematic analysis revealed two key themes: (1) the iPad is a universal panacea for distraction; and (2) trials and tribulations. Discussion: Participants considered iPads to be potentially useful and effective distraction tools, suitable for use with a wide range of patients with burn injuries including young children, adolescents and young adults. However, issues including health professionals’ understandings of one another’s roles, the challenge of working in a busy burns service, and lack of experience and confidence were identified as possible barriers to their use within routine burn care. Training for staff on the use of iPads as a means of facilitating distraction, development of guidelines and a review of how they are incorporated into routine burn care are recommended.
Enrichment in critical metals (In-Ge) and Te-Se in epithermal deposits of the ‘La Carolina’ district, San Luis, Argentina
Authors: Gallard-Esquivel M. C. , Cepedal A. , Fuertes-Fuente M. , Martin-Izard A. 
Published: March 2018

ABSTRACTEpithermal Au-Ag deposits of the La Carolina district, in the San Luis metallogenetic belt (Argentina), are related spatially and genetically to Mio-Pliocene volcanism. In this district, mineralization in the Cerro Mogote and Puesto La Estancia prospects occur as disseminations, veins and fracture/cavity infillings in volcanic/pyroclastic rocks, metamorphic basement and hydrothermal breccias. The gangue assemblage is dominated by carbonates (siderite, rhodochrosite, kutnahorite, dolomite). The main sulfides are pyrite, sphalerite, galena and chalcopyrite. Pyrite and sphalerite have compositional zoning, the former with As-rich cores and Cu-rich overgrowths, the latter with Fe-rich and Fe-poor bands. Sphalerite shows variable contents of Mn, Cu, In, Ga, Ge and Ag. The In-richest sphalerite hosts up to 5940 ppm In but also contains elevated concentrations of Cu, Ag, Ga and Ge, suggesting a coupled substitution mechanism resulting in enrichments in monovalent (Ag+, Cu+) and trivalent-tetravalent cations (Ga3+, In3+, Ge4+). The main precious metal minerals are Ag-rich tetrahedrite, acanthite, argyrodite, pearceite–polybasite and Au-Ag alloy. Locally, Se and/or Te-enriched minerals include galena Pb(S0.9–1Se0.1–0), hessite Ag2(Te0.9–1Se0.1–0), Se-rich cervelleite Ag4(Te1.3–0.9S1–0.5Se0.5–0.2), and also alburnite [Ag8GeTe2S4] and benleonardite [Ag15Cu(As,Sb)2S7Te4]. Pearceite contains Te (3.6–4.3 wt.%) and Se (1–2.3 wt.%) substituting for S, which are unusually high concentrations for this mineral. The Puesto La Estancia deposit contains various tellurides including sylvanite, petzite, stutzite, altaite, tellurobismuthite and volynskite. This study shows that the chemistry of the fluids fluctuated during ore deposition suggesting different fluid pulses (system rejuvenation and/or boiling). The enrichment in Te, Se and Bi enrichment is supportive of a magmatic contribution to the ore fluid, while graphite in the metamorphic basement could be the source of germanium, although a magmatic source cannot be ruled out.
The physiological regulation of macropinocytosis during Dictyostelium growth and development
Authors: Williams Thomas D. , Kay Robert R. 
Published: March 2018

ABSTRACT
Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we developed a high-throughput flow cytometry assay to measure macropinocytosis, and used it to identify inhibitors and investigate the physiological regulation of macropinocytosis. Dictyostelium has two feeding states: phagocytic and macropinocytic. When cells are switched from phagocytic growth on bacteria to liquid media, the rate of macropinocytosis slowly increases, due to increased size and frequency of macropinosomes. Upregulation is triggered by a minimal medium containing three amino acids plus glucose and likely depends on macropinocytosis itself. The presence of bacteria suppresses macropinocytosis while their product, folate, partially suppresses upregulation of macropinocytosis. Starvation, which initiates development, does not of itself suppress macropinocytosis: this can continue in isolated cells, but is shut down by a conditioned-medium factor or activation of PKA signalling. Thus macropinocytosis is a facultative ability of Dictyostelium cells, regulated by environmental conditions that are identified here.
This article has an associated First Person interview with the first author of the paper.
Association of delivery procedure with APGAR scores among neonates born to healthy Pakistani mothers: a pilot study
Authors: Khalid Muhammad Ali , Ghani Rida , Khalid Muhammad Fahad , Malik Muhammad Saad , Waqas Ahmed 
Published: March 2018

Background: The present study explores the factors associated with poor APGAR scores among singletons born to healthy Pakistani mothers. Methods: This cross-sectional study was conducted at a Tara Urea Medical Center, Iskandarabad Colony, district Mianwali, Pakistan from April 1 to August 30, 2017. Data was collected using a preformed proforma by a gynecologist and pediatrician during the birth procedure. The questionnaire comprised of two sections including neonatal and maternal characteristics. All data were analyzed in SPSS v.20. Results: Regression analysis revealed that vaginal deliveries were associated with higher APGAR scores at five minutes than those delivered by cesarean section. However, maternal age and BMI and weight of the baby did not yield significant association with APGAR scores at five minutes. APGAR scores assessed at one minute were significantly associated with weight of the neonate. Conclusion: APGAR scores of the neonates at birth are significantly associated with birth procedures. Therefore, birth procedure should be selected and managed effectively to reduce the risk of low APGAR scores.
Mitochondrial genomes of Anopheles arabiensis, An. gambiae and An. coluzzii show no clear species division
Authors: Hanemaaijer Mark J. , Houston Parker D. , Collier Travis C. , Norris Laura C. , Fofana Abdrahamane , Lanzaro Gregory C. , Cornel Anthony J. , Lee Yoosook 
Published: March 2018

Here we report the complete mitochondrial sequences of 70 individual field collected mosquito specimens from throughout Sub-Saharan Africa. We generated this dataset to identify species specific markers for the followingAnophelesspecies and chromosomal forms:An. arabiensis,An. coluzzii(TheForestandMoptichromosomal forms) andAn. gambiae(TheBamakoandSavannahchromosomal forms). The raw Illumina sequencing reads were mapped to the NC_002084 reference mitogenome sequence. A total of 783 single nucleotide polymorphisms (SNPs) were detected on the mitochondrial genome, of which 460 are singletons (58.7%). None of these SNPs are suitable as molecular markers to distinguish amongAn. arabiensis,An. coluzziiandAn. gambiaeor any of the chromosomal forms. The lack of species or chromosomal form specific markers is also reflected in the constructed phylogenetic tree, which shows no clear division among the operational taxonomic units considered here.
ANALISIS DAYA DUKUNG EKOLOGI UNTUK PENGEMBANGAN BUDIDAYA RUMPUT LAUT DI BAGIAN UTARA TELUK BONE
Authors: Arifin Taslim , Waluyo Waluyo 
Published: March 2018

Abstract : Waters carrying capacity in seaweed (Eucheuma cottonii) cultures should be a concern for optimum seaweed culture. Carrying capacity can determine by ecological footprint (EF) analysis, which in this research use production footprint. This research on Mei 2015 (1sttransitionalseason) and September 2015 (2ndtransitionalseason) in Luwu and Palopo, South Sulawesi. Map and land use analyzed with GIS (Geographic Information Systems).The results showed that theecological footprint production (EFP)in Luwu waters is 67.88 ton/capita/year, or equivalent to 235,823.93 tons/year.Based on the analysis of the availability of water for seaweed is 59,781.79 hectares, it can produce seaweed (biocapacity) for 1,437,779.60 tons/year and the number of farmers that allows for use the waters is 21,432 capita. The ecological footprint production (EFp) in Palopo waters is 3.08 ton/capita/year, or equivalent to 4,589.99 tons/year. Water availability analysis is 1,771.41 hectares are able to produce seaweed (biocapacity) for 18,287.46 ton/year and the number of farmers that allows for use the waters is 635 farmers capita. The results comparison between biocapacity and ecological footprint, ecological status for Luwu and Palopo waters are still in sustainable use.
Articulation and Liars
Authors: Oms Sergi 
Published: March 2018

AbstractJamie Tappenden was one of the first authors to entertain the possibility of a common treatment for the Liar and the Sorites paradoxes. In order to deal with these two paradoxes he proposed using the Strong Kleene semantic scheme. This strategy left unexplained our tendency to regard as true certain sentences which, according to this semantic scheme, should lack truth value. Tappenden tried to solve this problem by using a new speech act, articulation. Unlike assertion, which implies truth, articulation only implies non-falsity. In this paper I argue that Tappenden’s strategy cannot be successfully applied to truth and the Liar.