bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcendentalism Without Escape
Authors: Mastroianni Dominic 
Published: June 2019

AbstractThis essay-review asks what transcendentalism can contribute to our sense of the present moment and our capacity to imagine more just and livable futures. In doing so, it suggests an alternative to the view that transcendentalism embraces escapism and isolating individualism. I focus on Ralph Waldo Emerson and Henry David Thoreau, presuming that the present value of an idea of transcendentalism is to be discovered in their writings or nowhere. The two are centrally concerned with describing the conditions under which experience is acquired; their writing, then, evinces a wish to get closer to the world, not to escape it. What they do seek to transcend is not the world but our illusions about it, particularly those that feed egotism. The irony of calling Emerson in particular an escapist is that his writing makes escape so difficult to achieve. The process of reading Emerson—of finding a sentence suddenly captivating, just where it had been hopelessly dull—models and perhaps prompts a process of similar discovery about the mundane world. I conclude by linking transcendentalism to ideas of critical humility and naïveté suggested by Stanley Cavell, Toril Moi, Jane Bennett, and Theodor Adorno. Some form of naïveté, I speculate, might help us confront our inability to change in the midst of anthropogenic climate change and mass extinction.
Critique, Tweaked
Authors: Perrin Tom 
Published: June 2019

Abstract
Four recent monographs argue, in various ways, that the paradigm of critique is still a useful one for scholars to inhabit. Taken as a group, these authors broadly address the issues of how, and with what results, popular culture upholds hegemonic ideologies, and, by extension, whether the consumption of popular culture ought still to count as a guilty pleasure. Such questions are clearly related to the scholarly practice of studying popular culture by critiquing its ideological axioms. While these books all engage the problems with critique that have given rise to a contemporary postcritique movement, all ultimately conclude that key elements of critique remain useful as keystones of the study of literature and culture.
Nest illumination and the evolution of egg rejection in hosts of brood parasites
Authors: Medina Iliana , Langmore Naomi E 
Published: June 2019

ABSTRACT
Hosts of avian brood parasites, such as cuckoos, are duped into taking care of a foreign chick and this has led to the evolution of host defenses, such as egg rejection. However, many host species are not egg rejecters and it has been suggested that poor illumination inside closed nests may constrain the evolution of this defense. In this study, we experimentally increased the light inside the dome nests of Yellow-Rumped Thornbills, the main host of the Shining Bronze-Cuckoo. Our results show that rejection events did not increase significantly when nests were brighter, although there is a possibility that rejection mistakes could decrease. Moreover, we found that natural light levels inside dome nests were highly variable, and in many cases as high as those in cup-nesting species with high rejection rates. This evidence suggests that rapid changes in nest illumination do not alter rejection behavior.
Duetting correlates with territory quality and reproductive success in a suboscine bird with low extra-pair paternity
Authors: Diniz Pedro , Macedo Regina H , Webster Michael S 
Published: June 2019

AbstractDuetting has been intensively studied, but we still have little consensus about its fitness consequences. Some studies suggest that duetting functions in acoustic mate guarding to prevent cuckoldry (acoustic paternity guarding hypothesis), whereas other studies argue that duetting is a cooperative behavior to defend common resources (territory defense hypothesis). We tested these 2 hypotheses by investigating the relationships among song traits, extra-pair paternity, territory quality and reproductive success in the Rufous Hornero (Furnarius rufus), a Neotropical, socially monogamous bird. We found a low rate of extra-pair paternity (3.33% of 120 offspring and 6.52% of 46 broods), which suggests that acoustic paternity guarding is probably not a primary function of duetting behavior in this species. Female song output was positively correlated with territory quality, measured as the availability of territory foraging patches. The number of young that survived post-fledging was positively correlated with duet duration, but not with territory features. Our results support the territory defense hypothesis, suggesting that female song in duets might be used in the defense of food resources within territories. Our study provides the first evidence that song traits correlate with both territory features and reproductive success in a duetting species.
Are commonly used metrics of bird song complexity concordant?
Authors: Benedict Lauryn , Najar Nadje A 
Published: June 2019

AbstractResearchers studying the evolution of animal communication often ask what generates and maintains signal complexity, but they define and measure complexity in different ways. If different metrics are not concordant, then studies using them are probably not comparable. In this study, we asked whether 7 metrics of bird song complexity vary in tandem among individuals of a single species, the Rock Wren (Salpinctes obsoletus). The included metrics were chosen because they are regularly used by researchers in the field to test hypotheses within the literature. Results indicated that none of the metrics positively correlated with any others, suggesting that bird songs are not under general selective pressures favoring increased complexity across multiple features. If metrics of signal complexity are not correlated, then care should be taken when designing analyses and comparing results. Researchers should always clearly define the “complexity” under investigation and verify that it has significance to the study species. Contradictory outcomes among existing research into signal “complexity” may result from the fact that this single word is used to represent multiple independent traits.
Investigation of the geographic origin of burrowing owl fleas with implications for the ecology of plague
Authors: Navock Kara A , Johnson David H , Evans Samantha , Kohn Matthew J , Belthoff James R 
Published: June 2019

ABSTRACTHost-parasite relationships between Western Burrowing Owls (Athene cunicularia hypugaea) and the fleas (Pulex irritans, Siphonaptera:Pulicidae) they harbor were studied to understand the extent to which migratory Burrowing Owls translocated fleas from wintering grounds to breeding grounds. This has implications for host-parasite relationships in Burrowing Owls and also potentially for the dynamics of plague, as Burrowing Owl distributions overlap plague foci, owls inhabit fossorial mammal colonies where epizootic outbreaks of plague occur, and owls may harbor species of flea that are competent plague vectors. We used hydrogen stable isotope analysis to help elucidate geographic origins of fleas collected from adults and nestlings in 2 migratory populations of Burrowing Owls in Idaho and Oregon, USA. For adults, we posited that bird-mediated dispersal would impart flea isotopic compositions representative of southern latitudes and be similar to owl toenail tissue recently grown on wintering grounds, but they would differ from contour feathers presumably grown on breeding grounds the previous year. We assumed nestling feathers and toenails would have isotopic compositions representative of the breeding grounds. We analyzed contour feathers and toenails from adults collected shortly after they arrived in breeding grounds following spring migration and from nestlings later in the breeding season, to which we compared isotopic compositions in fleas collected from individuals of both age classes. Fleas on nestlings in both populations had isotopic compositions that did not differ from nestling feathers and toenails, suggesting that nestling fleas had breeding ground origins. Fleas on adults in one population (Oregon) had breeding ground isotopic signatures, as flea compositions did not differ from nestling feathers or toenails. Adult owls in Idaho had fleas that similarly did not express a wintering ground signature, but they were enriched in the heavy isotope (deuterium) relative to nestling feathers and toenails. Therefore, we discuss the possibility that adult owls in Idaho acquired fleas at migratory stopover sites. While the latter indicates that Burrowing Owls have the potential to disperse fleas, there was no evidence of continent-wide movement of fleas by owls from wintering grounds to breeding grounds.
Rabbits and Bergmann’s rule: how cold was Portugal during the last glaciation?
Authors: Davis Simon J M 
Published: June 2019

Abstract
Osteometric data from > 450 modern wild rabbits, mostly from Portugal, Spain and France, show an inverse correlation between their size and the temperature of the environment, in accordance with Bergmann’s rule. Similar measurements made on some 1660 rabbit bones from 14 Portuguese late Pleistocene and Holocene archaeological sites indicate that rabbits became considerably smaller at the Pleistocene–Holocene boundary. Thus, rabbit size varies or varied with temperature both today and in the past. A direct temperature–size relationship was assumed, and the regression of modern rabbit bone size on temperature was then used to calibrate the temperature equivalent for the change of size of rabbit bones in the past. The result indicates a Last Glacial Maximum to present-day difference, Δt°, of 7 or 8 °C. An alternative interpretation that does not assume a direct temperature–size relationship would indicate that the environment in Portugal 15 000–30 000 years ago was similar to that in northern France today.
Aligning Perspectives?—Comparison of Top and Middle-Level Managers’ Views on How Organization Influences Implementation of evidence-based practice
Authors: Bäck Annika , von Thiele Schwarz Ulrica , Hasson Henna , Richter Anne 
Published: June 2019

Abstract
A supportive organizational context is important for successfully implementing evidence-based practice (EBP). Managers have an important role in creating organizational prerequisites for EBP. The present study compared how top- and middle-level managers describe the process of implementing EBP and the factors influencing this process. Data were collected through interviews with twenty-two managers in social services, and analysed with thematic deductive analysis based on the Theoretical Domains Framework (TDF) and the COM-B model. Findings showed that top-level managers focused more on strategic- and system-level issues, e.g. external comparisons, dialogue with authorities and creating support systems, while the middle managers focused on the operative implementation at staff level, i.e. motivating and involving staff. Furthermore, the two groups had different understandings of EBP. To conclude, there needs to be an alignment in the understanding of, and support for, EBP between the different levels of managers. To create a mutual understanding of what EBP entails and to clearly communicate how the organization applies the different steps of the EBP process could be crucial steps in enabling the implementation of EBP, and needs to be done in dialogue between middle- and top-level managers.
Screening and identification of potential tyrosinase inhibitors from Semen Oroxyli extract by ultrafiltration LC-MS and in silico molecular docking
Authors: Yin Xing-shuo , Zhang Xue-qin , Yin Jin-tuo , Kong De-zhi , Li De-qiang 
Published: June 2019

AbstractThere is an increasing interest in screening and developing natural tyrosinase inhibitors widely applied in medicinal and cosmetic products, as well as in the food industry. In this study, an approach by ultrafiltration LC-MS and molecular docking was used to screen and identify tyrosinase inhibitors from Semen Oroxyli extract. The samples were first incubated with the tyrosinase to select the optimal binding conditions including tyrosinase concentration, incubation time and the molecular weight of ultrafiltration membrane. By comparison of the chromatographic profiles of the extracts after ultrafiltration with activated and inactivated tyrosinase, the potential inhibitors were obtained and then identified by LC-MS. The relative binding affinities of the potential inhibitors were also calculated based on the decrease of peak areas of those. As a result, seven compounds were fished out as tyrosinase inhibitors by this assay. Among them, oroxin A and baicalein showed higher tyrosinase inhibitory than resveratrol as positive drug, and their binding mode with enzyme was further verified via the molecular docking analysis. The test results showed that the proposed method was a simple, rapid, effective, and reliable method for the discovery of natural bioactive compounds, and it can be extended to screen other bioactive compounds from traditional Chinese medicines.
Invariant Natural Killer T-cell Dynamics in Human Immunodeficiency Virus–associated Tuberculosis
Authors: Walker Naomi F , Opondo Charles , Meintjes Graeme , Jhilmeet Nishtha , Friedland Jon S , Elkington Paul T , Wilkinson Robert J , Wilkinson Katalin A 
Published: June 2019

Abstract

Background
Tuberculosis (TB) is the leading cause of mortality and morbidity in people living with human immunodeficiency virus (HIV) infection (PLWH). PLWH with TB disease are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) when they commence antiretroviral therapy. However, the pathophysiology is incompletely understood and specific therapy is lacking. We investigated the hypothesis that invariant natural killer T (iNKT) cells contribute to innate immune dysfunction associated with TB-IRIS.

Methods
In a cross-sectional study of 101 PLWH and HIV-uninfected South African patients with active TB and controls, iNKT cells were enumerated using α-galactosylceramide-loaded CD1d tetramers and subsequently functionally characterized by flow cytometry. In a second study of 49 people with HIV type 1 (HIV-1) and active TB commencing antiretroviral therapy, iNKT cells in TB-IRIS patients and non-IRIS controls were compared longitudinally.

Results
Circulating iNKT cells were reduced in HIV-1 infection, most significantly the CD4+ subset, which was inversely associated with HIV-1 viral load. iNKT cells in HIV-associated TB had increased surface CD107a expression, indicating cytotoxic degranulation. Relatively increased iNKT cell frequency in patients with HIV-1 infection and active TB was associated with development of TB-IRIS following antiretroviral therapy initiation. iNKT cells in TB-IRIS were CD4+CD8– subset depleted and degranulated around the time of TB-IRIS onset.

Conclusions
Reduced iNKT cell CD4+ subsets as a result of HIV-1 infection may skew iNKT cell functionality toward cytotoxicity. Increased CD4– cytotoxic iNKT cells may contribute to immunopathology in TB-IRIS.
PICEAdatabase: a web database for Picea omics and phenotypic information
Authors: Lu Nan , Zhu Tianqing , Ouyang Fangqun , Xia Yan , Li Qingfen , Jia Zirui , Hu Jiwen , Ling Juanjuan , Ma Wenjun , Yang Guijuan , Zhang Hanguo , Kong Lisheng , Wang Junhui 
Published: June 2019

Abstract
Picea belongs to the Pinaceae family and is a famous commercial tree species because of its straight trunk and excellent timber traits. Recently, omics have been widely used for fundamental and mechanism studies on Picea plants. To improve the accessibility to omics and phenotypic data and facilitate further studies, we compiled the sequences of 2 chloroplast genomes (Picea crassifolia and Picea asperata) and 32 complete omics data sets, including 20 transcriptomes, 4 proteomes, 2 degradomes and 6 microRNAs from P. crassifolia, P. asperata, Picea balfouriana and Picea abies tissues under different treatments, in PICEAdatabase. In addition, phenotypic data on plant growth and wood property traits were collected from two field trials of P. crassifolia. PICEAdatabase also includes useful analysis tools, such as BLAST, DESeq2 and JBrowse, to assist with analyses.
High-resolution computational modeling of immune responses in the gut
Authors: Verma Meghna , Bassaganya-Riera Josep , Leber Andrew , Tubau-Juni Nuria , Hoops Stefan , Abedi Vida , Chen Xi , Hontecillas Raquel 
Published: June 2019

Abstract

Background
Helicobacter pylori causes gastric cancer in 1–2% of cases but is also beneficial for protection against allergies and gastroesophageal diseases. An estimated 85% of H. pylori–colonized individuals experience no detrimental effects. To study the mechanisms promoting host tolerance to the bacterium in the gastrointestinal mucosa and systemic regulatory effects, we investigated the dynamics of immunoregulatory mechanisms triggered by H. pylori using a high-performance computing–driven ENteric Immunity SImulator multiscale model. Immune responses were simulated by integrating an agent-based model, ordinary, and partial differential equations.

Results
The outputs were analyzed using 2 sequential stages: the first used a partial rank correlation coefficient regression–based and the second a metamodel-based global sensitivity analysis. The influential parameters screened from the first stage were selected to be varied for the second stage. The outputs from both stages were combined as a training dataset to build a spatiotemporal metamodel. The Sobol indices measured time-varying impact of input parameters during initiation, peak, and chronic phases of infection. The study identified epithelial cell proliferation and epithelial cell death as key parameters that control infection outcomes. In silico validation showed that colonization with H. pylori decreased with a decrease in epithelial cell proliferation, which was linked to regulatory macrophages and tolerogenic dendritic cells.

Conclusions
The hybrid model of H. pylori infection identified epithelial cell proliferation as a key factor for successful colonization of the gastric niche and highlighted the role of tolerogenic dendritic cells and regulatory macrophages in modulating the host responses and shaping infection outcomes.
Feeding the Australian family: challenges for mothers, nutrition and equity
Authors: Mehta Kaye , Booth Sue , Coveney John , Strazdins Lyndall 
Published: June 2019

Abstract
Australian women shoulder the bulk of household duties including family food provisioning, despite increasing participation in the workforce. This research aimed to understand employed mothers’ daily-lived experience of family food provisioning, in particular, the intersection between family food provisioning, gender inequality and nutritional guidelines as they impact women’s time and health. Semi-structured interviews were conducted with 22 employed mothers in South Australia. Participants had at least one child aged less than 13 years. Qualitative data was analysed using a thematic content approach. Time-scarcity was common and associated with stress in relation to family food provisioning; this relationship was particularly apparent among employed mothers who were also studying. Most mothers valued nutrition and strove to provide nutritious meals, although they tended to work from their own nutritional understandings, not the national nutrition guidelines; they saw the nutrition guidelines as unhelpful because of the time demands that were implied. The study invites policy makers, practitioners and researchers to consider time for family food provisioning as a social determinant of family as well as women’s health, and structural strategies to address this health inequity for women.
Extending the Geometric Approach for Studying Biomechanical Motions
Authors: Martinez C M , Wainwright P C 
Published: June 2019

AbstractWhether it is swimming, walking, eating, or jumping, motions are a fundamental way in which organisms interact with their environment. Understanding how morphology contributes to motion is a primary focus of kinematic research and is necessary for gaining insights into the evolution of functional systems. However, an element that is largely missing from traditional analyses of motion is the spatial context in which they occur. We explore an application of geometric morphometrics (GM) for analyzing and comparing motions to evaluate the outputs of biomechanical linkage models. We focus on a common model for oral jaw mechanics of perciform fishes, the fourbar linkage, using GM to summarize motion as a trajectory of shape change. Two traits derived from trajectories capture the total kinesis generated by a linkage (trajectory length) and the kinematic asynchrony (KA) of its mobile components (trajectory nonlinearity). Oral jaw fourbar data from two subfamilies of Malagasy cichlids were used to generate form–function landscapes, describing broad features of kinematic diversity. Our results suggest that kinesis and KA have complex relationships with fourbar morphology, each displaying a pattern in which different shapes possess equivalent kinematic trait values, known as many-to-one mapping of form-to-function. Additionally, we highlight the observation that KA captures temporal differences in the activation of motion components, a feature of kinesis that has long been appreciated but was difficult to measure. The methods used here to study fourbar linkages can also be applied to more complex biomechanical models and broadly to motions of live organisms. We suggest that they provide a suitable alternative to traditional approaches for evaluating linkage function and kinematics.
Health systems’ use of enterprise health information exchange vs single electronic health record vendor environments and unplanned readmissions
Authors: Vest Joshua R , Unruh Mark Aaron , Freedman Seth , Simon Kosali 
Published: June 2019

Abstract

Objective
Enterprise health information exchange (HIE) and a single electronic health record (EHR) vendor solution are 2 information exchange approaches to improve performance and increase the quality of care. This study sought to determine the association between adoption of enterprise HIE vs a single vendor environment and changes in unplanned readmissions.

Materials and Methods
The association between unplanned 30-day readmissions among adult patients and adoption of enterprise HIE or a single vendor environment was measured in a panel of 211 system-member hospitals from 2010 through 2014 using fixed-effects regression models. Sample hospitals were members of health systems in 7 states. Enterprise HIE was defined as self-reported ability to exchange information with other members of the same health system who used different EHR vendors. A single EHR vendor environment reported exchanging information with other health system members, but all using the same EHR vendor.

Results
Enterprise HIE adoption was more common among the study sample than EHR (75% vs 24%). However, adoption of a single EHR vendor environment was associated with a 0.8% reduction in the probability of a readmission within 30 days of discharge. The estimated impact of adopting an enterprise HIE strategy on readmissions was smaller and not statically significant.

Conclusion
Reductions in the probability of an unplanned readmission after a hospital adopts a single vendor environment suggests that HIE technologies can better support the aim of higher quality care. Additionally, health systems may benefit more from a single vendor environment approach than attempting to foster exchange across multiple EHR vendors.