bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinan Cakupan Imunisasi Dasar Lengkap pada Penerima Program Keluarga Harapan
Authors: Sari Wulan , Nadjib Mardiati 
Published: September 2019

Abstrak Kemiskinan merupakan permasalahan sosial bersifat multidimensi dan berhubungan dengan permasalahan kesehatan, pendidikan dan kesejahteraan sosial lainnya. Cakupan Imunisasi Dasar Lengkap (IDL) secara nasional mencapai 57,9%, 32,9% tidak lengkap dan sebanyak 9,2% tidak diimunisasi, sementara indikator cakupan secara nasional minimal 90% Penelitian ini bertujuan untuk mengetahui determinan apakah yang mempengaruhi cakupan imunisasi dasar lengkap pada bayi penerima Program Keluarga Harapan (PKH). Desain studi yang digunakan adalah cross sectional. Lokasi penelitian berada di 34 provinsi. Jumlah populasi sebanyak 9.205 responden dengan menggunakan data sekunder Survei Sosial Ekonomi Nasional (Susenas) tahun 2017. Hasil penelitian menunjukkan capaian imunisasi dasar lengkap sebesar 97,34% dan 2,66% tidak lengkap. Hasil penelitian menunjukkan variebel umur dan status perkawinan berhubungan positif serta berpengaruh secara signifikan, Variabel pendidikan dan pekerjaan berhubungan secara signifikan namun berhubungan negatif dalam cakupan imunisasi dasar. PKH telah memberikan kesempatan dan akses kepada rumah tangga miskin untuk melaksanakan program imunisasi dasar lengkap. Oleh karena itu diperlukannya penguatan supervisi terhadap ibu muda, ibu dengan status cerai, serta ibu yang bekerja guna meningkatkan pengetahuan, membangun kesadaran, menjaga serta memperkuat perubahan perilaku terkait, pengasuhan dan kesehatan untuk meningkatkan cakupan imunisasi dasar pada bayi. Abstract Poverty is a multidimensional social problem and related to the problems of health, education and other social welfare. National Basic Immunization Coverage (IDL) reached 57.9%, with 32.9% was incomplete and 9.2% were not immunized, while national coverage indicators were at least 90%. This study aims to determine the determinants that affects basic complete immunization coverage for babies receiving the Family Hope Program (PKH). The study design used was cross sectional. The research was located in 34 provinces. The total population is 9,205 respondents using secondary data from the National Socio-Economic Survey (Susenas) in 2017. The research shows that the achievement of complete basic immunization is 97.34% and 2.66% is incomplete. The results shows that age and marital status are positively related and significantly influence the basic immunization coverage, while education and employment variables are significantly associated but negatively related to basic immunization coverage. PKH has provided opportunities and access to poor households in implementing a complete basic immunization program. So it is necessary to intensify the supervision of young mothers, divorced mothers and working mothers to boost knowledge, build awareness, maintain and strengthen related behav­ioral changes, health and care to increase the coverage of basic immunization in infants.
Cell‐Tailored Multi‐Chamber Cd5(PO4)3Cl/CdO Mesocrystals Hetero‐Superstructure Toward Promoting Charge Transfer for Enhanced Photocatalytic H2 Evolution
Authors: Song Penghui , Zhang Tianqi , Chang Yi , Ma Guanglei , Tang Lingxue , Yu Heng , Ren Xueqing , Bai Zhengyu , Guo Yuming , Ma Xiaoming 
Published: December 2024

AbstractElaborate mesocrystal superstructures assembled by nanocrystals enable the photocatalysts to effectively transfer photo‐generated charges over long‐distance. Especially, the hetero superstructure can facilely adjust the bandgaps to promote the separation of electron–hole pairs and enhance photocatalytic activity. Herein, a unique bio‐derived mesocrystal superstructures with multi‐chamber network is developed tactfully using the yeast cells with multi‐ascopore as templates obtained by sexual reproduction way. Specifically, the natural phosphorus and oxygen species derived from the yeast are tactfully exploited during the synthetic process of Cd5(PO4)3Cl/CdO hetero‐superstructure. The transient surface photovoltage and the time‐resolved transient photoluminescence (PL) result indicate that the well‐defined orientation of the mesocrystal contributes to enhancing photogenerated carriers transfer efficiency and reducing the recombination of electron–hole pairs. The hetero‐superstructures exhibit an excellent solar H2 releasing activity (18.71 mmol·g−1·h−1) and a high quantum yield of 28.27% at wavelength of 380 nm. The design of hetero‐superstructure with multi‐chamber by means of the inner interlaced network and microelements of the organisms introduces a new clue to construct functional materials with hierarchical structures for solar fuel conversion.
Synergistic Multimodal Energy Dissipation Enhances Certified Efficiency of Flexible Organic Photovoltaics beyond 19%
Authors: Li Haojie , Le Jinglin , Tan Hao , Hu Lin , Li Xin , Zhang Kai , Zeng Shumin , Liu Qianjin , Zhang Meng , Shi Linfeng , Cai Zheren , Liu Siqi , Li Hongxiang , Ye Long , Hu Xiaotian , Chen Yiwang 
Published: December 2024

AbstractAll‐polymer organic solar cells (OSCs) have shown unparalleled application potential in the field of flexible wearable electronics in recent years due to the excellent mechanical and photovoltaic properties. However, the small molecule acceptors after polymerization in still retain some mechanical and aggregation properties of the small molecule, falling short of the ductility requirements for flexible devices. Here, based on the multimodal energy dissipation theory, the mechanical and photovoltaic properties of flexible devices are co‐enhanced by adding the thermoplastic elastomer material (polyurethane, PU) to the PM6:PBQx‐TF:PY‐IT‐based active layer films. The construction of multi‐fiber network structure and the decrease of films’ residual stresses contribute to the enhancement of carrier transport properties and the decrease of defect state density. Eventually, the PCE (power conversion efficiency) of 19.40% is achieved on the flexible devices with an effective area of 0.102 cm2, and the third‐party certified PCE reaches 19.07%, which is the highest PCE for flexible OSCs currently available. To further validate the potential of this strategy for large‐area module applications, the 25‐cm2‐based flexible and super‐flexible modules are prepared with the PCEs of 15.48% and 14.61%, respectively, and demonstration applications are implemented.
High‐Performance Green and Blue Light‐Emitting Diodes Enabled by CdZnSe/ZnS Core/Shell Colloidal Quantum Wells
Authors: Zhu Yunke , Lu Xiuyuan , Qiu Jingjing , Bai Peng , Hu An , Yao Yige , Liu Qinyun , Li Yang , Yu Wenjin , Li Yaolong , Jin Wangxiao , Zhu Xitong , Deng Yunzhou , Liu Zhetong , Gao Peng , Zhao XiaoFei , Zhu Youqin , Zhou Li , Jin Yizheng , Gao Yunan 
Published: December 2024

AbstractThe unique anisotropic properties of colloidal quantum wells (CQWs) make them highly promising as components in nanocrystal‐based devices. However, the limited performance of green and blue light‐emitting diodes (LEDs) based on CQWs has impeded their practical applications. In this study, alloy CdZnSe core CQWs with precise compositions are tailored via direct cation exchange (CE) from CdSe CQWs with specific size, shape, and crystal structure and utilized hot‐injection shell (HIS) growth to synthesize CdZnSe/ZnS core/shell CQWs exhibiting exceptional optoelectronic characteristics. This approach enabled the successful fabrication green and blue LEDs manifesting superior performance compared to previously reported solution‐processed CQW‐LEDs. The devices demonstrated a remarkable peak external quantum efficiency (20.4% for green and 10.6% for blue), accompanied by a maximum brightness 347,683 cd m−2 for green and 38,063 cd m−2 for blue. The high‐performance represents a significant advancement for nanocrystal‐based light‐emitting diodes (Nc‐LEDs) incorporating anisotropic nanocrystals. This work provides a comprehensive synthesis strategy for enhancing the efficiency of Nc‐LEDs utilizing anisotropic nanocrystals.
Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts
Authors: Xing Mengmeng , Wang Fei , Chu Ruowen , Wang He , Sun Yuyao , Qian Meng , Jiang Huan , Midgley Adam C. , Dai Guohao , Zhao Qiang 
Published: December 2024

AbstractDecellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. Recent advances in vascular biology highlight the pivotal role of COUP‐TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification. Here, plasmid DNA (pDNA) encoding COUP‐TFII is incorporated into decellularized allografts to realize localized delivery. Comprehensive in vitro investigation complemented by a bone marrow transplantation model on genetic‐lineage‐tracing mouse revealed the underlying mechanisms of COUP‐TFII in regulating vascular regeneration and remodeling. COUP‐TFII augmented endothelialization and inhibited calcification in decellularized allografts by modulating the Ang1/Tie2/PI3K/AKT signaling pathway that dictates the fate of Sca‐1+ stem/progenitor cells. Heparin‐polyethyleneimine nanoparticles (HEPI) are prepared as COUP‐TFII pDNA nanocarriers (COUP‐TFII@HPEI) and used to modify decellularized allografts, achieving long‐term and stable overexpression of COUP‐TFII. Functionalized grafts are evaluated in rat abdominal artery replacement models, demonstrating enhanced neo‐artery regeneration without calcification. The study provides an effective strategy to enhance the applicability of decellularized allograft and illustrates their translational prospects for vascular bypass grafting.
Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment
Authors: Shi Tingwang , Wu Qiong , Ruan Zesong , Luo Zhiyuan , Wang Wenbo , Guo Zhao , Ma Yihong , Wang Xin , Chu Guangyu , Lin Han , Ge Min , Chen Yunfeng 
Published: December 2024

AbstractSmall colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms. In this study, phenotypically stable SCV strains are successfully recovered from clinical specimens, characterized by elevated drug resistance and reduced immunogenicity. Multi‐omics analysis revealed that the acquired high drug resistance is associated with altered flux in the purine metabolism pathway, attributable to mutations in the hypoxanthine phosphoribosyltransferase (hpt) gene. Furthermore, this study innovatively discovered that lonidamine, an inhibitor of cellular energy metabolism, can effectively mitigate SCV resistance to β‐lactam antibiotics, thereby facilitating its eradication. The underlying mechanism involves the reprogramming of purine metabolism. Therefore, a co‐delivery system for lonidamine and oxacillin is constructed with amino‐modified dendritic mesoporous silica as a carrier, which showed high efficacy and safety in combating SCV both in vitro and in vivo experiments. Overall, this study elucidated the pathogenic mechanisms of a class of clinically isolated SCV isolates with hpt mutations and provided a paradigm for treating SCV‐associated osteomyelitis by reprogramming purine metabolism.
A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
Authors: Xia Xiancheng , Li Yang , Huang Rongkang , Wang Yuanbin , Xiong Wenxuan , Zhou Hui , Li Min , Lin Xidong , Tang Youchen , Zhang Bo 
Published: December 2024

AbstractTransarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin‐loaded lipiodol emulsion (denoted as ICN‐LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron‐doped carbon nanozymes (ICN) to mitigate the issue of lipiodol‐water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE.
Spontaneous Emergence of Lipid Vesicles in a Coacervate‐Based Compartmentalized System
Authors: Yin Chengying , Yu Xinran , Wu Baohu , Tian Liangfei 
Published: December 2024

AbstractThe spontaneous emergence of lipid vesicles in the absence of evolved biological machinery represents a major challenge for bottom‐up synthetic biology. We show that coacervate microdroplets could create a compartmentalized environment that enriches lipid molecules and facilitates their spontaneous assembly into lipid vesicles. These vesicles can escape from the coacervate microdroplets in a continuous process under non‐equilibrium conditions, resembling a constant production process akin to a “primitive enzyme” factory assembly line. These findings significantly extend our understanding of the intricate interaction between lipid molecules and coacervate microdroplets, shedding light on the emergence of cellular systems and offering a new perspective on the conditions necessary for the development of life on Earth.
A BOIMPY Dye Enables Multi‐Photoinduced Electron Transfer Catalysis: Reaching Super‐Reducing Properties
Authors: Biswas Amit , Kolb Simon , Röttger Sebastian H. , Das Arpan , Patalag Lukas J. , Dey Partha P. , Sil Swagata , Maji Subir , Chakraborty Soumi , Wenger Oliver S. , Bhunia Anup , Werz Daniel B. , Mandal Swadhin K. 
Published: December 2024

AbstractAn established concept to create radical intermediates is photoexcitation of a catalyst to a higher energy intermediate, subsequently leading to a photoinduced electron transfer (PET) with a reaction partner. The known concept of consecutive photoinduced electron transfer (con‐PET) leads to catalytically active species even higher in energy by the uptake of two photons. Generally speaking, increased photon uptake leads to a more potent reductant. Here, we report the concept of multi‐photoinduced electron transfer catalysis (>2 photons), termed multi‐PET, which is enabled by photoinduced one‐electron reductions of an organic dye. Further irradiation of the doubly reduced species leads to a photoexcited dianionic super‐reductant, which is more potent than Li metal – one of the strongest chemical reductants known. This multi‐photon process which is enabled by 390 nm LEDs allows the cleavage of strong carbon‐fluorine bonds and reduction of other halides even in very electron‐rich substrates. The resulting radicals are quenched by hydrogen atoms or engaged in carbon‐carbon and carbon‐phosphorus bond formations, highlighting the utility of multi‐PET for organic chemistry. In addition, multi‐PET enabled Birch‐type reductions. Spectroscopic, chemical and computational investigations are presented to gain mechanistic insights.
Metal‐Bridging Cyclic Bilatriene Analogue Affords Stable π‐Radicaloid Dyes with Near‐Infrared II Absorption
Authors: Ghosh Aninda , Mori Shigeki , Ide Yuki , Song Jun Tae , Yamaoka Yoshihisa , Ishihara Tatsumi , Ikeue Takahisa , Furuta Hiroyuki , Ishida Masatoshi 
Published: December 2024

AbstractStable neutral metal radicaloid complexes have been synthesized from a modified tetrapyrrolic pigment, bilatriene, with iridium(I) and rhodium(I) cyclooctadiene (COD) synthons. The bilatriene skeleton contains α‐linked conjugated pyrrole units, whereas an N‐confused analogue used in this work possesses β‐linked pyrrole moieties at the terminal, demonstrating a unique metal binding capability. Unprecedentedly, the metal‐COD cations are accommodated at the outer nitrogen sites, which induced the formation of open‐shell metal‐radicaloid species. The resulting compounds are highly stable under ambient conditions and demonstrated facile redox conversion to afford the corresponding cation and anion species. Furthermore, the radicaloid complexes showed a distinct second near‐infrared absorption (NIR‐II) capability extending up to 1500 nm along with high photostability. These features emphasized that the complexes can be potential NIR‐II light‐responsible photothermal and photoacoustic imaging contrast agents based on the metal‐radicaloid dye platform.
Polystyrene‐MOF‐Derived 3D Hierarchical Porous Carbon for High‐Performance Supercapacitors
Authors: Kumar Nitish , Kumar Pathak Prakash , Bansal Neetu , Ahamad Tansir , Park Changyong , Ahn Heejoon , Salunkhe Rahul R. 
Published: December 2024

AbstractThe ability to tailor surface area, porosity, and morphologies has driven extensive research into the synthesis of metal‐organic frameworks derived carbons and their applications in energy storage. This study presents the development of three‐dimensional hierarchically porous carbon derived from polystyrene and small‐sized zeolitic imidazolate framework‐8 (ZIF‐8) particles. Incorporating nanometer‐sized ZIF‐8 particles forms a core‐shell structure in the pre‐carbonization stage, transforming into a porous carbon material with a range of pores from micro to macropores after carbonization. The carbonized material's electrode demonstrates a high capacitance of 428.8 F g−1 at 1 mV s−1 in the three‐electrode setup and a very high specific energy of 48.75 Wh kg−1 at 50 mA g−1 in the packed flat cell configuration. This exceptional electrochemical performance is attributed to the composite carbon material's high surface area, well‐developed pore structure, and self‐doped nitrogen content.
Combination of Phenylsilsesquioxane and Acetate Ligands as an Approach to a Record High Nuclear Cu13Na2‐Cage. Synthesis, Unique Structure, and Catalytic Activity
Authors: Bilyachenko Alexey N. , Khrustalev Victor N. , Huang Zhibin , Dorovatovskii Pavel V. , Shubina Elena S. , Lobanov Nikolai N. , Wang Zhi , Ragimov Karim , Reis Conceição Nuno , Mahmoud Abdallah G. , Pombeiro Armando J. L. 
Published: December 2024

AbstractSelf‐assembly synthesis of mixed‐ligand (silsesquioxane/acetate) complex allows to isolate record high nuclear copper(II) Cu13‐cage (1). In the presence of two additional sodium ions, a unique molecular architecture, with triple combination of ligands (cyclic and acyclic silsesquioxanes as well as acetates), has been formed. The structure was established by single‐crystal X‐ray diffraction based on the use of synchrotron radiation. Complex 1 was evaluated as precatalyst in the Baeyer–Villiger oxidation of cyclohexanone towards ϵ‐caprolactone, employing hydrogen peroxide, tert‐butyl hydroperoxide (TBHP) or m‐chloroperoxybenzoic acid (mCPBA) as oxidants, in an aqueous acidic acetonitrile medium. The direct formation of the lactone from cyclohexane via a tandem peroxidative oxidation/Baeyer–Villiger oxidation was also studied. For both substrates, the best results (ϵ‐caprolactone yields up to 100 % or 26 %, from cyclohexanone or cyclohexane, respectively) were achieved with mCPBA under considerably mild conditions, i. e., conventional heating at 50 °C for 4 h or microwave (MW) irradiation at 80 °C for only 30 minutes.
Hydroxamate‐Based Metal‐Organic Frameworks
Authors: Sugamata Koh 
Published: December 2024

AbstractThis mini‐review focuses on recent developments in hydroxamate‐based metal–organic frameworks (MOFs), which exhibit unique structures and properties distinct from those of carboxylate‐based MOFs. Hydroxamates (RCONHO−) form MOFs with novel structural motifs and functionalities. In this review, synthetic strategies, structural characteristics, and functional applications of key examples of hydroxamate‐based MOFs are described, providing insights into the influence of the hydroxamate ligand on the MOF properties compared to that of the carboxylate‐based analogues.
General Acetal‐Protected Aldehyde Strategy for Facile Synthesis of Covalent Organic Frameworks with Splendid Crystallinity and Uniform Morphology
Authors: Song Wen , Ren Xitong , Bai Feng , Tian Yajie , Li Yusen 
Published: December 2024

AbstractCrystallinity and morphology are critical factors that closely related to the properties and applications of covalent organic frameworks (COFs). However, the controlled synthesis of COFs with both high crystallinity and uniform morphology remains a significant challenge due to uncontrollable polymerization and complex reaction conditions. In this work, we present a general acetal‐protected aldehyde protocol for the facile synthesis of imine‐linked COFs, which enables the simultaneous optimization of crystallinity and morphology. Of the acetal‐protected aldehydes explored, ethanediol‐protected terephthalaldehyde (Tp‐E) emerged as the most effective, balancing stability and reactivity to yield highly crystalline Py‐COF‐E with a well‐defined hollow spherical morphology and a significantly enhanced BET surface area compared to its aldehyde‐based counterpart Py‐COF. This synthetic approach demonstrates broad adaptability across various framework topologies, precursor species, and synthetic solvent systems, simplifying the typically laborious solvent screening process in COF synthesis. Furthermore, Py‐DBT‐COF‐E showed superior photocatalytic H2 evolution performance relative to Py‐DBT‐COF, despite their identical chemical compositions, emphasizing the critical role of crystallinity and morphology in determining functional performance. Overall, this study provides a versatile methodology for the controlled synthesis of COFs and offers valuable insights into the interconnected roles of morphology, crystallinity, and material performance.
A pilot study of the value of micronucleus count in urinary cytology samples in the follow‐up of patients with urothelial carcinoma: Implications for diagnosis and prognosis
Authors: Kökenek Ünal Tuba Dilay , Aksoy Altınboğa Ayşegül 
Published: December 2024

AbstractBackgroundNuclear protrusions such as micronuclei (MNs) and nuclear budding (NB) are morphological findings of chromosomal instability and indicators of genotoxic damage. They are increased in malignancies, and their high frequency may be used in the diagnosis of cancers and the follow‐up of patients. Urothelial carcinomas are common tumors that cause morbidity and mortality, and cytology is a commonly used method for the monitoring and screening of urothelial carcinoma. Although the cytological evaluation of urinary samples is mainly based on nuclear features, there is limited research focusing on MN frequency in urinary cytology. This study aimed to investigate MN and NB counts in various diagnostic categories of urinary samples.MethodsThis study included 117 urinary cytology samples categorized according to The Paris System for Reporting of Urinary Cytology. Two observers, blinded to the diagnosis, counted the frequency of MNs and NB per 1000 cells on May‐Grünwald‐Giemsa– and Papanicolaou‐stained slides.ResultsMN and NB counts significantly differed among the groups (p < .001 for each) with a large effect (Ɛ2 = 0.509). MN and NB counts were significantly higher in cases with high‐grade urothelial carcinoma (HGUC) than in control cases and in cases that were negative for HGUC or with atypical urothelial cells (p < .001 for each). Any MN count greater than 2.5 per 1000 cells indicated HGUC with a 55% sensitivity and 92.4% specificity.ConclusionsBecause increased MN and NB frequencies are closely associated with an increased risk of malignancy, these could be integrated into The Paris System for Reporting of Urinary Cytology.