bluuebunny/crossref_metadata_2025_split huggingface dataset:
SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells
Authors: Kim Yong Chan , Kim Kee Kwang , Yoon Jeongheon , Scott David W. , Shevach Ethan M. 
Published: August 2018

Abstract
Clinical application of Ag-specific T regulatory cells (Tregs) offers promise for the treatment of undesirable immune diseases. To achieve this goal, long-term expansion of Tregs is required to obtain sufficient numbers of cells. However, human Tregs are not stable ex vivo. Therefore, we previously developed an innovative Treg expansion protocol using 25mer-phosphorothioated random oligonucleotides (ODNps25). The addition of ODNps25 successfully resulted in the stabilization of engineered Ag-specific Tregs; however, the mechanism is not fully characterized. We first identified sterile α motif histidine-aspartate–domain containing protein 1 (SAMHD1) as an ODNps25-binding protein using a UV–cross-linking pull-down strategy. SAMHD1 physically interacted with the 3′ untranslated region of Foxp3 mRNA and was translocated from nucleus to cytoplasm after ODNps25 treatment. Importantly, addition of ODNps25 enhanced the interaction of SAMHD1 and Foxp3 mRNA significantly, and this interaction was increased by TCR stimulation. Because ODNps25 binds to the nuclease (HD) domain of SAMHD1, we then established that overexpression of a dNTPase-deficient mutant (D137N) in Tregs significantly stabilized the expression level of the Foxp3 protein. Furthermore, we found that TCR stimulation upregulates phosphorylation of the threonine residue (Thr592), which is a regulatory site to control SAMHD1 activity, and phosphorylation of Thr592 is critical to control SAMHD1 activity to stabilize the expression of Foxp3 and Helios in Tregs. Taken together, we suggest that the interaction of ODNPs25 in HD or phosphorylation of Thr592 by TCR stimulation interferes with nuclease activity of SAMHD1, thereby stabilizing 3′ untranslated region of Foxp3 and Helios mRNAs in long-term culture.
Effect of Thiosulfate on Pitting Corrosion of Ni-Cr-Fe Alloys in Chloride Solutions
Authors: Becerra Araneda Abraham A. , Kappes Mariano A. , Rodríguez Martín A. , Carranza Ricardo M. 
Published: August 2018

Pitting corrosion of Alloys 600, 690, and 800 (UNS N06600, N06690, and N08800) was studied in 1 M NaCl solution with different concentrations of thiosulfate (). Alloys exhibited vastly different electrochemical behavior, depending on the concentration and chromium content of the alloy. Alloy 600 exhibited a breakdown and repassivation potential that decreased with decreasing concentration, in the range from 1 M to 10−4 M. Breakdown and repassivation potentials decreased about 300 mV and 600 mV, respectively, when 10−4 M was added to a 1 M NaCl solution. For Alloys 690 and 800, additions of in the range of 1 M to 0.01 M caused a decrease in the breakdown and repassivation potentials. Dilute solutions were more aggressive, and a 0.01 M addition of to a 1 M NaCl solution caused a decrease in breakdown and repassivation potentials of about 300 mV. In a solution containing 0.001 M Na2S2O3 + 1 M NaCl, Alloys 690 and 800 showed two different submodes of pitting, each one of them existing at a different range of potential. Chloride pitting corrosion was observed at high potentials and was characterized by pits with a lacy cover. The stable pit initiation potential associated with this process in both alloys was near 300 mVAg/AgCl and was preceded by frequent metastable events. Chloride plus pitting was observed at low potentials (near −225 mVAg/AgCl) and was characterized by hemispherical pits. In potentiodynamic curves, this submode of pitting showed a characteristic anodic peak of approximately 120 mV width and a maximum current density of 10 μA/cm2 for both alloys. Potentiostatic tests at potentials within this anodic peak led to stable pit growth. Those pits could be repassivated by scanning the potential either in noble or active directions. Low-potential and high-potential pitting submodes were separated by a stable passivity range, as determined by potentiodynamic curves. Upon a further decrease in concentration down to 10−4 M, only high-potential pitting corrosion was observed, with pitting and repassivation potentials similar than those in 1 M NaCl solution.
Conselho editorial
Authors: Vaz Caroline De F�tima Matiello 
Published: August 2018

Secretariado Executivo em Revist@
N� 14/2018

ISSN 1809-2802

Acesso: www.upf.br/seer

EDITORA

Josete Alzira Passamani Stocco
Universidade de Passo Fundo � UPF, Rio Grande do Sul, Brasil

EDITORA CIENT�FICA

Caroline de F�tima Matiello Vaz
Universidade de Passo Fundo � UPF, Rio Grande do Sul, Brasil

CONSELHO EDITORIAL

Aline Cantarotti, Universidade Estadual de Maring� � UEM, Paran�, Brasil
Cibele Barsalini Martins, Universidade Federal de Santa Catarina � UFSC, Santa Catarina, Brasil
Cibelle da Silva Santiago, Universidade Federal da Para�ba � UFPB, Para�ba, Brasil
Chussy Karlla Souza Antunes, Universidade Federal de Pernambuco � UFPE, Pernambuco, Brasil
Daniela Giareta Durante, Universidade Federal do Cear� - UFC, Cear�, Brasil
Eduardo C�sar Pereira Souza, Universidade Cruzeiro do Sul � UNICSUL, S�o Paulo, Brasil
Emili Barcellos Martins Santos, City University of Seattle, Seattle, Washington
Eliane Wamser, Universidade Regional de Blumenau � FURB, Santa Catarina, Brasil
Fernanda Cristina Sanches, Universidade Estadual do Oeste do Paran� � UNIOESTE, Paran�, Brasil
Keila Raquel Wenningkamp, Universidade Estadual do Oeste do Paran� � UNIOESTE, Paran�, Brasil
Maria do Carmo Assis Todorov, Universidade Nove de Julho � Uninove, S�o Paulo, Brasil
Maria Elisabete Mariano dos Santos, Universidade de Passo Fundo � UPF, Rio Grande do Sul, Brasil
Maria Luzitana Concei��o dos Santos, Universidade Federal da Para�ba � UFPB, Para�ba, Brasil
Raul Vitor Oliveira Paes, Universidade Federal do Par� � UFPA, Par�, Brasil
Rodrigo M�ller, Universidade Tecnol�gica Federal do Paran� - UFTPR, Brasil
Rosimeri Ferraz Sabino, Universidade Federal de Sergipe - UFS, Sergipe, Brasil
Phosphorus Fertilization Under Different Land Preparation Methods and Performance of Groundnut (Arachis hypogea L.) in Rainforest Zone of Southern Nigeria
Authors: Ogeh Joseph Sunday , Oyibo Rukeme Orakpogbake 
Published: August 2018

A field experiment was conducted on an Arenic paleudult in the rainforest zone of Southern Nigeria to determine the response of an improved variety of peanut (Arachis hypogea L. var. Samnut 23) to phosphorus, under different land preparation methods. Selected land preparation methods were “slash and burn” (SB) and “slash and mulch” (SM), and the phosphate fertilizer rates were 0, 30, 60, 90 and 120 kg P ha-1. The experiment was laid out as a randomized complete by block design. Each land preparation was divided into plots. Macro- and micro nutrient contents of peanut plants were determined, and the growth and yield components were also assessed. Results showed that the pre planting soil analysis for the SB management had a pH of 5.77, N (1.8 gkg-1), P (2.05 mgkg-1) and K (0.11cmol (+) kg-1), while that of the SM had a pH of 5.95, N (0.9 g kg-1), P (0.86 mg kg-1) and K (0.07cmol(+)kg-1). Plant height was not significantly different (pd” 0.05) in the land preparation methods, but leaf area was significantly different. However, plant height and leaf area responded better under the SB treatment with 90 kg P ha-1 rate of phosphorus fertilizer than the SM treatment under the same rate. Fresh pod weight of 908.6kg ha-1 and dry pod weight of 558.0kg ha-1 was obtained at 60 kg P ha-1 under the SB treatment and was significantly different from all other treatments including the SM. Significant differences were also observed in the nutrient concentrations of leaves and roots. Highest leaf phosphorus content (3.502 mg kg-1) was recorded at 90kg P ha-1 in the SM treatment while the highest nutrient content of P in the roots (0.272 mg kg-1) was recorded at 30 kg P ha-1 also in the SM treatment. However, the SB treatment recorded the highest peanut seed pods / shell at 60 kg P ha-1. Generally, phosphorus fertilization under the SB management practice gave better results than the SM management practice.Keywords: groundnut, land preparation, phosphorus fertilization, Slash and burn, slash and mulch [How to Cite: Joseph SO and RO Oyibo. 2014. Phosphorus Fertilization Under Different Land Preparation Methods and Performance of Groundnut (Arachis hypogea L.) in Rainforest Zone of Southern Nigeria. J Trop Soils 19(1): 1-7. Doi: 10.5400/jts.2014.19.1.1]
Estudos sobre poder, imaginação e historicidade dos anos 1970 e 1980: apontamentos para o debate atual
Authors: Marcelino Douglas Attila 
Published: August 2018

Este artigo analisa estudos sobre diferentes formas de historicidade publicados nos anos 1970 e 1980, indicando que o tema foi abordado, em casos importantes, como vinculado ao poder e ao imaginário. Problemas como o das ideologias, das utopias, do poder criador da imaginação e das formas do imaginário social foram abordados em obras de autores como Claude Lefort, Paul Ricoeur e Cornelius Castoriadis por meio de uma vinculação estreita com as formas de experimentação do tempo. O tratamento das distintas formas de historicidade, por Marshall Sahlins, pressupunha uma concepção holística e histórica das culturas marcadamente caracterizada pela atenção ao poder como elemento fundamental da vida em coletividade. A partir do exame dos pressupostos dessas abordagens, pretende-se estabelecer apontamentos preliminares que podem auxiliar na reflexão sobre os modos de tratamento das formas de historicidade em perspectiva histórica. São analisados, sobretudo, os pressupostos ontológicos e as concepções de sociedade ou cultura que caracterizaram esses estudos, contrapondo-os com formulações que têm importante repercussão na historiografia atualmente, como a categoria “regime de historicidade”. Palavras-chave: Temporalidade Histórica. Imaginação e Imaginário Social. Regimes de Historicidade. Ideologias e Utopias. Anos 1970 e 1980.
Doping: A Key Enabler for Organic Transistors
Authors: Xu Yong , Sun Huabin , Liu Ao , Zhu Hui‐Hui , Li Wenwu , Lin Yen‐Fu , Noh Yong‐Young 
Published: August 2018

AbstractOrganic field‐effect transistors (OFETs) are the central building blocks of organic electronics, but still suffer from low performance and manufacturing difficulties. This is due in part to the absence of doping, which is mostly excluded from OFET applications for the concern about uncontrollable dopant diffusion. Doping enabled the modern semiconductor industry to build essential components like Ohmic contacts and P–N junctions, empowering devices to function as designed. Recent breakthroughs in organic semiconductors and doping techniques demonstrated that doping can also be a key enabler for high‐performance OFETs. However, the knowledge of organic doping remains limited particularly for OFET use. Therefore, this review addresses OFET doping from a device perspective. The paper overviews doping basics and roles in advanced complementary technologies. These fundamentals help to understand why and how doping provides the desired transistor characteristics. Typical OFETs without doping are discussed, with consideration for operating principle and problems caused by the absence of doping. Achievements for channel, contact, and overall doping are also examined to clarify the corresponding doping roles. Finally, doping mechanisms, techniques, and dopants associated with OFET applications are reviewed. This paper promotes fundamental understanding of OFET doping for the development of high‐performance OFETs with doped components.
Base‐Promoted Oxidative Dearomatization of Pyrroles to 4‐Pyrrolin‐2‐ones
Authors: Huang Huabin , Hu Bing , Lai Yuanfa , Zou Zhongai , Lin Huixia , Xiao Yujuan , You Qihua , Shen Jinhai 
Published: August 2018

AbstractA base‐promoted oxidative dearomatization of substituted pyrroles for the synthesis of 3,3‐disubstituted 4‐pyrrolin‐2‐ones under mild reaction conditions is described. A cascade aerobic oxidation/semipinacol rearrangement reaction was involved, and the desired products bearing a quaternary carbon center were efficiently prepared using molecular oxygen (O2) as an ideal oxidant.magnified image
Carbon Dots as Multifunctional Phototheranostic Agents for Photoacoustic/Fluorescence Imaging and Photothermal/Photodynamic Synergistic Cancer Therapy
Authors: Lan Minhuan , Guo Liang , Zhao Shaojing , Zhang Zhenyu , Jia Qingyan , Yan Li , Xia Jing , Zhang Hongyan , Wang Pengfei , Zhang Wenjun 
Published: August 2018

AbstractPhototheranostics combines diagnosis and image‐guided therapy of disease using a single agent, which makes it a potential clinical approach for cancer treatment. However, as the core element of phototheranostics, most phototheranostic agents are activated by the UV–visible light, which falls outside of the phototherapy window and results in poor tissue penetration capability. Moreover, they are in general only capable of generating reactive oxygen species or heat. To integrate photodynamic and photothermal therapies into a single treatment modality is thus expected to broaden the applicability and improve the efficiency of this technique. In this work, carbon dots (CDs) with absorption range up to 1100 nm are synthesized by hydrothermal treatment of 1,3,6‐trinitropyrene and Na2SO3. The CDs could simultaneously present strong fluorescence and generate 1O2 through two‐photon excitation mechanism, and they also show outstanding photothermal conversion capability under irradiation by an 800 nm femtosecond pulsed laser. Moreover, the broad absorption spectrum of the CDs enable them to be used as an agent for photoacoustic (PA) imaging. The in vitro and in vivo experiments demonstrate that the CDs have good biocompatibility and can serve as multifunctional phototheranostic agents for PA/fluorescence imaging, and photodynamic/photothermal synergistic cancer therapy using a single near‐infrared laser.
Ultrasound liver imaging reporting and data system®: Considerations for routine practice
Authors: Kutaiba Numan , Archard Robyn 
Published: August 2018

AbstractHepatocellular carcinoma (HCC) is a growing problem worldwide. In Australia, both the incidence and mortality of HCC have sharply increased over the last few decades. Unless detected in its early stage, prognosis of HCC is grim. Ultrasound represents the main screening tool for surveillance programmes worldwide and is recommended in the guidelines by all relevant bodies. The American College of Radiology introduced the first edition of Ultrasound Liver Imaging Reporting and Data System (US LI‐RADS) in 2017 to propose an algorithm for reporting ultrasound studies performed in the setting of HCC screening and to provide technical recommendations. The algorithm has two components: detection scores and visualisation scores. More recently at our institution, we introduced a visualisation score to our routine work to assess visualisation of the liver. The score, which is applied by the sonographer performing the ultrasound study at the time of examination, comprises three categories that are not dissimilar to the score introduced by US LI‐RADS; adequate, adequate with limitations and inadequate. We believe that adopting a visualisation score is easy and important. It provides clinicians with information regarding the quality of the ultrasound study and the confidence in excluding HCC based on ultrasound alone. Attempts to improve ultrasound screening efficiency such as applying targeted liver ultrasounds and recording of a visualisation score are encouraged with the aim of improving patients’ outcomes.
Plasma Assisted Preparation of CoPt/SiO2 Fischer‐Tropsch Catalysts: A Comparison of the Precursor Pre‐Thermal Treated Temperatures
Authors: Liu Chen , Liu Hao , Wang Bo , Hong Jingping , Zhao Fuzhen , Sun Fenglou , Jin Shiwei , Liu Chengchao , Zhang Yuhua , Li Jinlin 
Published: August 2018

AbstractA series of amorphous silica supported Co‐based catalysts were prepared using traditional incipient wetness impregnation methods followed by thermal treatment at different temperatures. Glow discharge plasma effects on cobalt species in the forms of cobalt nitrate, mixture of cobalt nitrate and Co3O4, and pure Co3O4 were compared and investigated by various characterizations and Fischer‐Tropsch synthesis (FTS) tests. Plasma enhancing metal dispersion effect was mostly happened during the decomposition of cobalt nitrate in plasma field; when cobalt species was already in the form of Co3O4, no apparent particle size change by plasma treatment was observed. Under the promotion of Pt, all the catalysts maintained at high reduction degree, thus the cobalt dispersion was almost linearly related to the number of active sites. The CoSi‐100D+P catalyst with both high cobalt dispersion and high cobalt reducibility, had the maximum number of active sites, and presented the highest FTS activity. Meanwhile, the product selectivity could also be affected by plasma treatment, hydrocarbons were shifted to lower carbon numbers. This effect could be observed even on the CoSi‐400C+P sample, in which the precursor was pre‐thermal treated at high temperature (400 °C), and cobalt species was already all transformed into Co3O4.
Effect of soybean (Glycine max (L.) Merr.) flour inclusion on the nutritional properties and consumer preference of fritters for improved household nutrition
Authors: Alamu Emmanuel Oladeji , Popoola Ibironke , Maziya‐Dixon Busie 
Published: August 2018

AbstractDiets in populations of most developing countries are often deficient in protein, carbohydrates, and fat, leading to protein‐energy malnutrition (PEM). Diet‐based strategies are the most promising approach for a sustainable control of PEM. This study aimed to investigate the effects of soy flour inclusion on the nutritional properties, consumer preference, purchase intent, and willingness to pay for wheat‐based fritters. The proximate composition of both types of fritters was determined using standard methods, Consumer preference survey on organoleptic properties was carried out among 291 participants (93 men, 198 women) in Chipata, Katete, and Lundazi districts of Eastern Zambia. The soy‐fortified fritters had significantly higher (p < 0.05) levels of ash, fat, amylose, crude fiber, and protein than the unfortified fritters. Protein, crude fiber, amylose, and ash contents of soy‐fortified fritters were considerably increased by 55.5%, 18.9%, 98%, and 30.6%, respectively. The overall preference showed no significant difference (p > 0.05) between unfortified and soy‐fortified fritters. A larger percentage of participants in Katete (38%) and Chipata (41%) preferred the soy‐fortified fritters to the nonfortified one. In addition, no significant difference (p > 0.05) was also observed for intention to purchase between both types of fritters across the three locations. In conclusion, incorporating 20% soybean flour into fritters, which showed better nutrients quality, could be used to alleviate PEM among fritters consuming populations of developing countries, particularly in Sub‐Saharan Africa.
Methyl‐Substituted α‐Cyclodextrin as Affinity Material for Storage, Separation, and Detection of Trichlorofluoromethane
Authors: Ryvlin Dimitrij , Girschikofsky Maiko , Schollmeyer Dieter , Hellmann Ralf , Waldvogel Siegfried R. 
Published: August 2018

AbstractThe severely ozone‐depleting trichlorofluoromethane is still appearing in several recycling processes or industrial applications. A simple and selective supramolecular complex formation of per‐methylated α‐cyclodextrin (1) with the highly volatile trichlorofluoromethane (2) is reported. This interaction moreover leads to thermally stable crystals. Per‐methylated α‐cyclodextrin is successfully exploited as a reversible and selective adsorption material for liquid and airborne trichlorofluoromethane as well as an affinity material for the chemical sensing and detection of this particular volatile organic component.
Analysis of readmissions after transoral robotic surgery for oropharyngeal squamous cell carcinoma
Authors: Parhar Harman S. , Gausden Elizabeth , Patel Jayendrakumar , Prisman Eitan , Anderson Donald W. , Durham J. Scott , Rush Barret 
Published: August 2018

AbstractBackgroundAs transoral robotic surgery (TORS) is being increasingly used to treat patients with oropharyngeal squamous cell carcinoma (OPSCC), there is an interest in determining contributors to readmission.MethodsWe conducted this retrospective multivariate analysis modeling 30‐day readmission using the Nationwide Readmissions Database (2012–2014).ResultsOf 950 patients, 117 (12.3%) were readmitted. Hemorrhage and diet/aspiration accounted for 32.5% and 19.7% of readmissions, respectively. Of those readmitted, 23.1% required operative bleeding control, 11.1% required transfusion, 1.7% required tracheostomy, and 18.8% required gastrostomies. Those readmitted were older (mean 63.2 years, SD 9.5 vs 60.9 mean years, SD 10.3) and had longer hospitalizations (mean 5.7 days, SD 6.8 vs mean 4.3 days, SD 4.1) and higher rates of aspiration/pneumonia (9.4% vs 2.4%, P < .01) on index admission. Multivariate analysis demonstrated that aspiration/pneumonia on index admission was independently associated with readmission (OR 3.128, 95% CI 1.178‐8.302).ConclusionsOf the patients 12.3% were readmitted within 30 days with hemorrhage and diet complications as significant contributors.
Predictors of graft function after parathyroid autotransplantation during thyroid surgery
Authors: Zhang Deguang , Gao Li , He Gaofei , Chen Jian , Fang Liang 
Published: August 2018

AbstractBackgroundThe purpose of this study was to identify predictors associated with graft function after parathyroid autotransplantation during thyroid surgery.MethodsOne hundred fifty patients who underwent thyroid surgery with parathyroid autotransplantation were enrolled prospectively. During surgery, the misresected or devascularized parathyroid gland was autografted in the brachioradialis muscle of the forearm. Parathyroid hormone (PTH) levels in both arms were measured regularly after surgery. Patient age, sex, extent of surgery, and postoperative serum calcium levels were recorded.ResultsGraft function was documented in 115 patients (76.7%). Univariate analysis revealed that graft function had a significant association with lower serum calcium level 1 day after surgery. The cutoff point was 2.11 mmol/L, which was confirmed by a receiver‐operating characteristic (ROC) curve.ConclusionLow serum calcium levels in the early postoperative period may stimulate a functional recovery in an autografted parathyroid gland. Therefore, a moderate calcium supplement strategy was recommended for patients who underwent parathyroid autotransplantation during the early stage after total thyroidectomy.