bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative methods in philosophy of language
Authors: Ventura Rafael 
Published: July 2019

AbstractIn this paper, I survey and defend the use of quantitative methods in philosophy of language. Quantitative methods in philosophy of language include a wide variety of methods, ranging from model‐based techniques (computer simulations and mathematical models) to data‐driven approaches (experimental philosophy and corpus‐based studies). After offering a few case studies of these methodologies in action, I single out some debates in philosophy of language that are especially well served by their use. These are cases in which quantitative methods increase precision, improve the accuracy and reliability of results, and allow philosophers of language to borrow from other fields the best epistemic practices available. I conclude with some far‐reaching considerations about the role of qualitative and quantitative methods in debates about philosophical methodology.
Relation of Photochemical Internalization to Heat, pH and Ca2+ Ions
Authors: Soe Tet Htut , Nanjo Tomotaka , Watanabe Kazunori , Ohtsuki Takashi 
Published: July 2019

AbstractThe inefficient endosomal escape of drugs or macromolecules is a major obstacle to achieving successful delivery to therapeutic targets. An efficient approach to circumvent this barrier is photochemical internalization (PCI), which uses light and photosensitizers for endosomal escape of the delivered macromolecules. The PCI mechanism is related to photogenerated singlet oxygen, but the mechanism is still unclear. In this study, we examined the relation of PCI to heat, pH and Ca2+ ions using cell penetrating peptide (CPP)‐cargo‐photosensitizer (Alexa546 or Alexa633) conjugates. A cell temperature changing experiment demonstrated that heat (thermal mechanism) does not significantly contribute to the photoinduced endosomal escape. Inhibition of V‐ATPase proton pump activity and endosomal pH upregulation indicated that PCI‐mediated endosomal escape needs endosomal acidification prior to photoirradiation. Imaging of the CPP‐cargo‐photosensitizer and Ca2+ ions during photostimulation showed that intracellular calcium increase is not the cause of the endosomal escape of the complex. The increment is mainly due to Ca2+ influx. These findings show the importance of extra‐ and intracellular milieu conditions in the PCI mechanism and enrich our understanding of PCI‐related changes in cell.
Biochemical characteristics support the recently described species Karlodinium zhouanum (Gymnodiniales, Dinophyceae)
Authors: Zhu Xiaojuan , Zhou Chengxu , Meng Ran , Li Shuang , Fang Keyi , Luo Zhaohe , Xu Jilin , He Shan , Luo Qijun , Yan Xiaojun 
Published: July 2019

SUMMARYThe small athecate dinoflagellate Karlodinium zhouanum is a species recently described in the coastal waters of China. K. zhouanum is morphologically similar to Karlodinium veneficum, a typical ichthyotoxic blooming karlotoxin‐producing species, and it is impossible to distinguish between these two species based on light microscopy. In this study, strains of K. zhouanum isolated from the East China Sea were studied. By analyzing toxins, toxicity, lipid characteristics and typical molecular and physiological traits of this species, K. zhouanum was shown to be nontoxic to brine shrimp and widely spread over the coastal waters of China. No karlotoxin‐like toxin was detected by liquid chromatography‐mass spectrometry (LC–MS). Instead of gymnodinosterol, the critical sterol in toxic K. veneficum, 27(nor)‐24S‐4α‐Methyl‐5α‐ergosta‐8(14)‐en‐3β‐ol (NEE) was dominant in K. zhouanum, while gymnodinosterol was absent. These sterol characteristics may provide not only support for the species separation between toxic and nontoxic species of Karlodinium but also environmental survey tools to differentiate the contribution of nontoxic Karlodinium strains, which has been unclear until now.
Patterns of protein glycosylation in bovine placentomes as a function of gestational age and in retained versus non‐retained placenta
Authors: Wawrzykowski Jacek , Franczyk Monika , Kankofer Marta 
Published: July 2019

AbstractThe formation of placenta at the beginning of pregnancy and its separation at parturition require not only deep remodelling of extracellular matrix, which mainly consists of proteins conjugated with sugar moieties, but also the cooperation with cells from both maternal and foetal parts of placenta. The aim of the study was to compare the patterns of selected conjugated proteins with sugar moieties between pregnant and term placenta as well as between released and retained placenta in cows. Placental samples from healthy pregnant cows (3–5 months of pregnancy) were collected at a slaughterhouse (n = 6), and parturient samples were collected during caesarean section at term and retrospectively divided into retained (n = 6) and released (n = 6). The pattern of selected sugar moieties conjugated with proteins was detected by use of lectin blotting with Phaseolus Vulgaris leucoagglutinin, Maackia Amurensis and Sambucus Nigra (Elderberry). The comparison and analysis of obtained band patterns showed differences between their number, molecular weight and abundance related to the intensity of staining. Samples from 3 to 4 months showed similarities, while at the 5th month, clear differences were visible in all 3 lectins, which were used in this study. Samples from retained/released placenta expressed significant differences in PHA‐L and SNA pattern in the foetal part. Obtained results indicate that the development of placenta related to extracellular matrix and accompanying cells from both sides of placenta shows dynamic changes during pregnancy. Moreover, in the case of animals with the retention of foetal membranes the patterns of proteins conjugated with sugar moieties are altered, suggesting that the changes in extracellular matrix metabolism can be involved in the attachment and detachment of the placenta in cows.
Loss/Gain Framing, Dose, and Reactance: A Message Experiment
Authors: Ratcliff Chelsea L. , Jensen Jakob D. , Scherr Courtney L. , Krakow Melinda , Crossley Kaylee 
Published: July 2019

AbstractWhether a loss or gain frame has a persuasive advantage in communicating health risks is a matter of ongoing debate. Findings reported in the literature are mixed, suggesting that framing effects are likely complex and may be influenced by a combination of factors. This study examined reactance as a mediator and dose as a moderator of loss/gain framing effects. Adults (N = 1,039) read framed messages about the health consequences of physical (in)activity in varying message doses (i.e., number of framed statements). Compared to loss frames, gain frames generated more threat to freedom and reactance. Dosage exerted significant influence at the extremes; the one‐dose messages invoked less intentions to exercise compared to the four‐dose messages. Planned contrasts revealed significant frame × dose interactions. Notably, the one‐dose gain‐framed messages triggered significantly more freedom threat and less intentions to engage in physical activity—a situation that changed when the information was loss‐framed or when the dosage was increased.
Group life shapes the psychology and biology of health: The case for a sociopsychobio model
Authors: Haslam S. Alexander , Haslam Catherine , Jetten Jolanda , Cruwys Tegan , Bentley Sarah 
Published: July 2019

AbstractEngel presented a compelling case for a biopsychosocial model of health. This challenged a biomedical model that he saw as reductionistic, physicalistic, and exclusionist. Yet despite its laudable goals and popularity, the biopsychosocial model can be faulted for being incremental, imprecise, and individualistic. Ultimately, this means it is no less reductionist than the biomedical model which it sought to supplant. In this paper, we present a reformulation of this model that foregrounds the capacity for social groups—and the social contexts in which those groups are embedded—to structure psychology and, through this, biology and health. This sociopsychobio model argues that the three elements of Engel's framework are not fixed and immutable but rather dynamic and interdependent. The model is consistent with a range of recent approaches to health that have focused on the important role that social class, social inequality, social structure, and social networks play in shaping health outcomes. In this paper, though, the concrete value of this reformulation is illustrated through a discussion of recent research that focuses on the role of group memberships and associated social identities in shaping the psychology and biology of stress. This review underlines two key points that are central to the general case for a sociopsychobio model of health. First, that groups are a force in the world that shape the psychology and biology of their members (as well as members of other groups) in ways that cannot be reduced to those group members' functioning as individuals. Second, that groups provide their members with a basis for seeking to change the world rather than simply accepting it. In this, group life is not merely an appendage to psychology and biology but is instead a basis for collective experiences that have the potential to unleash new expressions of both.
Resolving subcellular plant metabolism
Authors: Fürtauer Lisa , Küstner Lisa , Weckwerth Wolfram , Heyer Arnd G. , Nägele Thomas 
Published: July 2019

SummaryPlant cells are characterized by a high degree of compartmentalization and a diverse proteome and metabolome. Only a very limited number of studies has addressed combined subcellular proteomics and metabolomics which strongly limits biochemical and physiological interpretation of large‐scale ’omics data. Our study presents a methodological combination of nonaqueous fractionation, shotgun proteomics, enzyme activities and metabolomics to reveal subcellular diurnal dynamics of plant metabolism. Subcellular marker protein sets were identified and enzymatically validated to resolve metabolism in a four‐compartment model comprising chloroplasts, cytosol, vacuole and mitochondria. These marker sets are now available for future studies that aim to monitor subcellular metabolome and proteome dynamics. Comparing subcellular dynamics in wild type plants and HXK1‐deficient gin2‐1 mutants revealed a strong impact of HXK1 activity on metabolome dynamics in multiple compartments. Glucose accumulation in the cytosol of gin2‐1 was accompanied by diminished vacuolar glucose levels. Subcellular dynamics of pyruvate, succinate and fumarate amounts were significantly affected in gin2‐1 and coincided with differential mitochondrial proteome dynamics. Lowered mitochondrial glycine and serine amounts in gin2‐1 together with reduced abundance of photorespiratory proteins indicated an effect of the gin2‐1 mutation on photorespiratory capacity. Our findings highlight the necessity to resolve plant metabolism to a subcellular level to provide a causal relationship between metabolites, proteins and metabolic pathway regulation.
Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses
Authors: Morgan Rhiannon E. , Fiske‐Jackson Andrew R. , Hellige Maren , Gerhauser Ingo , Wohlsein Peter , Biggi Marianna 
Published: July 2019

AbstractOdontogenic tumors present as locally invasive, slow growing, firm swellings on the face. They are rare in all species and are characterized histologically by the degree of differentiation and dental tissue of origin. Radiographic appearance is not pathognomonic for these lesions. Computed tomographic (CT) examination allows exact determination of tumor extension and aggressiveness. The objectives of this retrospective, case series study were to describe the clinical presentation, CT characteristics, and outcome in horses with histologically confirmed odontogenic tumors, and to identify imaging features suggestive of individual types of tumors. Four ameloblastomas, two ameloblastic carcinomas, three ameloblastic fibromas, and two complex odontomas were included. All but one complex odontoma presented as a single mass. All tumors were associated with maxillary or mandibular bone expansion, alveolar and cortical bone lysis, and cortical bone thinning. The majority also had cortical bone thickening and periosteal proliferation. All tumors contained some degree of mineral attenuation, although only the complex odontomas contained enamel attenuation allowing differentiation from other types of odontogenic tumors in this study. Ameloblastomas were found to have variable CT characteristics likely due to the sub‐groups of ameloblastomas. Both ameloblastic carcinomas contained a mixture of mineralized and soft tissue attenuating material whereas ameloblastic fibromas were mainly composed of soft tissue attenuating material. Computed tomographic characteristics of odontogenic tumors generally indicate that they are expansile, aggressive tumors and can occur in a wide range of ages. Further investigation is needed to elucidate differences between each type of equine odontogenic tumor.
Automorphisms of graph products of groups from a geometric perspective
Authors: Genevois Anthony , Martin Alexandre 
Published: July 2019

AbstractThis article studies the structure of the automorphism groups of general graph products of groups. We give a complete characterisation of the automorphisms that preserve the set of conjugacy classes of vertex groups for arbitrary graph products. Under mild conditions on the underlying graph, this allows us to provide a simple set of generators for the automorphism groups of graph products of arbitrary groups. We also obtain information about the geometry of the automorphism groups of such graph products: lack of property (T) and acylindrical hyperbolicity.The approach in this article is geometric and relies on the action of graph products of groups on certain complexes with a particularly rich combinatorial geometry. The first such complex is a particular Cayley graph of the graph product that has a quasi‐median geometry, a combinatorial geometry reminiscent of (but more general than) CAT(0) cube complexes. The second (strongly related) complex used is the Davis complex of the graph product, a CAT(0) cube complex that also has a structure of right‐angled building.
Surface Quality and Contamination on Si Wafer Surfaces Sliced Using Wire-Electrical Discharge Machining
Authors: Joshi Kamlesh , Padhamnath Pradeep , Bhandarkar Upendra , Joshi Suhas S. 
Published: July 2019

Abstract
In the past, studies on wire-electrical discharge machining (EDM) of Si wafers have often focused on the effect of energy-related parameters on various wafer characteristics. However, comprehensive treatment on analyzing the effect of non-energy parameters of the Si wafer slicing process is not available thus far. This work, therefore, presents an extensive experimental work considering the parameters like wire tension (WT), wire feed rate (WF), and dielectric flushing pressure (WaP) on crucial wafer characteristics such as wafer-thickness and its uniformity, thermal damage, wire material contamination on wafer surfaces, and surface quality. A total of 72 experiments were performed at low and high servo voltage (SV) conditions. The sliced wafers were characterized by SEM, EDAX, and ICP-AES techniques. Ultrathin wafers with a uniform thickness of ∼107 µm were sliced at high SV conditions, while a lower thermal damage (∼10 µm) with low wire contamination was observed during low SV conditions. The percentage of contamination was further found to decrease with an increase in WT, WF, and WaP during low SV conditions. The wafer surface etching showed the diffusion of contaminates like Cu/Zn up to a depth of 25–30 µm. The wafer surface roughness in the middle section has always been observed to be poor due to short-circuiting and arcing within that zone.
Soft-Elastohydrodynamic Lubrication Line Contact Analysis on a Strip of Bio-Materials
Authors: Chen Qie-Da , Li Wang-Long 
Published: July 2019

Abstract
The characteristics of anisotropic material, finite deformation, and lubrication in biological system diminish the friction and wear between soft tissues with relative motion. In this research, the lubrication between pleura surfaces in relative motion is analyzed by soft elastohydrodynamic lubrication (soft-EHL) line contact with an equivalent model. The model is a soft, transversely isotropic (TI) elastic strip with finite thickness sliding under a rigid sinusoidal surface, which is used to simulate the surface irregularities, with lubricant in between. The material nonlinearity and the curvature effects due to finite deformation, which are significant in soft-EHL, are considered in the present study. The pressure distribution, film thickness, von Mises stress, and material deformation are analyzed and discussed under various combinations of elastic moduli and Poisson's ratios for the transversely isotropic models. The simulation results reveal that the soft-EHL modeling fit actual result better than the traditional EHL (t-EHL) modeling. The Poisson's ratio νp = 0.1 and νpz = 0.49 situation will have more gentle stress distribution. The present soft-EHL solver can be used to realize some desired stress distributions and to identify the mechanical properties bio-materials under the aids of experiments.
ACOUSTICAL STANDARDS NEWS
Authors: Mennigke Caryn , Struck Christopher J. 
Published: July 2019

American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To receive a copy of the latest Standards catalog, please contact Neil Stremmel.
Comments are welcomed on all material in Acoustical Standards News.
This Acoustical Standards News section in JASA, as well as the national catalog of Acoustical Standards and other information on the Standards Program of the Acoustical Society of America, are available via the ASA home page: http://acousticalsociety.org.
Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia
Authors: Leang Rithea , Khim Nimol , Chea Huch , Huy Rekol , Mairet-Khedim Melissa , Mey Bouth Denis , Dorina Bustos Maria , Ringwald Pascal , Witkowski Benoit 
Published: July 2019

This single-arm trial (
n
= 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in
Plasmodium falciparum
malaria.
Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis
Authors: Matsuura Masato , Murata Hiroshi , Fujino Yuri , Yanagisawa Mieko , Nakao Yoshitaka , Tokumo Kana , Nakakura Shunsuke , Kiuchi Yoshiaki , Asaoka Ryo 
Published: July 2019

AimsCorvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).MethodsA total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.ResultsIOPg, IOPcc and GAT IOP were significantly associated with CCT (p<0.001), whereas bIOP was not significantly associated with CCT (p=0.19). IOPg, bIOP and GAT IOP were significantly associated with CH (IOPg: p<0.001; bIOP: p<0.001; GAT IOP: p=0.0054), whereas IOPcc was not significantly associated with CH (p=0.18). All of IOP records were associated with CRF (p<0.001).ConclusionThe bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.
Protocol for a prospective observational study on the association of variables obtained by contrast-enhanced ultrasonography and sepsis-associated acute kidney injury
Authors: Liu Ning , Zhang Zhongheng , Hong Yucai , Li Bing , Cai Huabo , Zhao Hui , Dai Junru , Liu Lian , Qian Xin , Jin Qicheng 
Published: July 2019

IntroductionSepsis commonly results in acute kidney injury (AKI), whereas about 50% of AKI cases are due to sepsis. Sepsis-associated acute kidney injury (SA-AKI) increases morbidity and mortality especially among critically ill patients. This study aims to monitor renal microcirculation perfusion during sepsis using contrast-enhanced ultrasonography (CEUS), and to explore whether CEUS is useful for predicting the development of SA-AKI.Methods and analysisThis prospective observational study will enrol patients who were diagnosed with sepsis-3 definition. The total of septic or septic shock patients were stratified into AKI (including stages 1, 2 and 3) and non-AKI groups according to Kidney Disease Improving Global Outcomes criteria on days 0, 1, 2 and 7 after admission to the emergency intensive care unit, meanwhile, the CEUS technique will be performed to monitor renal microcirculation perfusion. A multivariable model including all CEUS variables were expected to create for predicting the development of AKI during sepsis. Ultrasonography results, demographic information, therapeutic interventions, survival outcomes, laboratory and other clinical datas will also be collected for further analysis.Ethics and disseminationThe study protocol was approved on 2 August 2017 by the Ethics Committee of Sir Run Run Shaw Hospital (Zhejiang University Medical College) (approval number: 2016C91401). The results will be published in a peer-reviewed journal and shared with the worldwide medical community within 2 years after the start of the recruitment.Trial registration numberISRCTN14728986
Is there a relationship between female genital mutilation/cutting and fistula? A statistical analysis using cross-sectional data from Demographic and Health Surveys in 10 sub-Saharan Africa countries
Authors: Matanda Dennis Juma , Sripad Pooja , Ndwiga Charity 
Published: July 2019

ObjectivesLiterature on associations between female genital mutilation/cutting (FGM/C) and fistula points to a common belief that FGM/C predisposes women to developing fistula. This study explores this association using nationally representative survey data.DesignA secondary statistical analysis of cross-sectional data from Demographic and Health Surveys was conducted to explore the association between FGM/C and fistula.SettingSub-Saharan Africa.ParticipantsWomen aged 15–49 years in Burkina Faso (n=17 087), Chad (n=17 719), Côte d’Ivoire (n=10 060), Ethiopia (n=14 070), Guinea (n=9142), Kenya (n=31 079), Mali (n=10 424), Nigeria (n=33 385), Senegal (n=15 688) and Sierra Leone (n=16 658).Main outcome measuresFistula symptoms.ResultsMultivariate logit modelling using pooled data from 10 countries showed that the odds of reporting fistula symptoms were 1.5 times (CI 1.06 to 2.21) higher for women whose genitals were cut and sewn closed than those who had undergone other types of FGM/C. Women who attended antenatal care (ANC) (adjusted odds ratio (AOR) 0.51, CI 0.36 to 0.71) and those who lived in urban areas (AOR 0.62, CI 0.44 to 0.89) were less likely to report fistula symptoms than those who did not attend ANC or lived in rural areas.ConclusionsSevere forms of FGM/C (infibulation) may predispose women to fistula. Contextual and socioeconomic factors may increase the likelihood of fistula. Multisectoral interventions that concurrently address harmful traditional practices such as FGM/C and other contextual factors that drive the occurrence of fistula are warranted. Promotion of ANC utilisation could be a starting point in the prevention of fistulas.