bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and validity of the Brief 2-Way Social Support Scale: an investigation of social support in promoting older adult well-being
Authors: Obst Patricia , Shakespeare-Finch Jane , Krosch Daniel J , Rogers Elizabeth J 
Published: March 2019

Objectives: This study aimed to explore the relationship between well-being and perceived stress, and the functional dimensions of social support in older adults. Method: Data from 306 older adults were obtained in a survey containing the two-way Social Support Scale (2-Way SSS). Also, a subset of the sample ( N = 165) was filled out with measures of well-being and perceived stress, and a follow-up survey was completed 3 months later ( N = 111). Results: Confirmatory factor analyses and reliability analyses provide evidence for a 12-item Brief 2-Way SSS as a reliable and valid measure of the four domains of Social Support. Correlations and regression analyses indicated the scale displayed good concurrent and predictive validity across time points, with receiving emotional support positively associated with well-being at Time 1 (T1) and Time 2 (T2), and Receiving Instrumental Support negatively associated with perceived stress at TI and T2. Conclusions: This study provides support for the importance of examining the influence of separable elements of social support on psychological outcomes in older adults. The Brief 2-Way SSS was found to have good psychometric properties in this sample of older adults.
FVIII expression by its native promoter sustains long-term correction avoiding immune response in hemophilic mice
Authors: Merlin Simone , Famà Rosella , Borroni Ester , Zanolini Diego , Bruscaggin Valentina , Zucchelli Silvia , Follenzi Antonia 
Published: March 2019

Abstract
Here we describe a successful gene therapy approach for hemophilia A (HA), using the natural F8 promoter (pF8) to direct gene replacement to factor VIII (FVIII)–secreting cells. The promoter sequence and the regulatory elements involved in the modulation of F8 expression are still poorly characterized and biased by the historical assumption that FVIII expression is mainly in hepatocytes. Bioinformatic analyses have highlighted an underestimated complexity in gene expression at this locus, suggesting an activation of pF8 in more cell types than those previously expected. C57Bl/6 mice injected with a lentiviral vector expressing green fluorescent protein (GFP) under the pF8 (lentiviral vector [LV].pF8.GFP) confirm the predominant GFP expression in liver sinusoidal endothelial cells, with a few positive cells detectable also in hematopoietic organs. Therapeutic gene delivery (LV.pF8.FVIII) in hemophilic C57/Bl6 and 129-Bl6 mice successfully corrected the bleeding phenotype, rescuing up to 25% FVIII activity, using a codon-optimized FVIII, with sustained activity for the duration of the experiment (1 year) without inhibitor formation. Of note, LV.pF8.FVIII delivery in FVIII-immunized HA mice resulted in the complete reversion of the inhibitor titer with the recovery of therapeutic FVIII activity. Depletion of regulatory T cells (Tregs) in LV-treated mice allowed the formation of anti-FVIII antibodies, indicating a role for Tregs in immune tolerance induction. The significant blood loss reduction observed in all LV.pF8.FVIII-treated mice 1 year after injection confirmed the achievement of a long-term phenotypic correction. Altogether, our results highlight the potency of pF8-driven transgene expression to correct the bleeding phenotype in HA, as well as potentially in other diseases in which an endothelial-specific expression is required.
Perioperatively Acquired Weakness
Authors: Lachmann Gunnar , Mörgeli Rudolf , Kuenz Sophia , Piper Sophie K. , Spies Claudia , Kurpanik Maryam , Weber-Carstens Steffen , Wollersheim Tobias 
Published: March 2019

BACKGROUND:
Skeletal muscle failure in critical illness (intensive care unit-acquired weakness) is a well-known complication developing early during intensive care unit stay. However, muscle weakness during the perioperative setting has not yet been investigated.

METHODS:
We performed a subgroup investigation of a prospective observational trial to investigate perioperative muscle weakness. Eighty-nine patients aged 65 years or older were assessed for handgrip strength preoperatively, on the first postoperative day, at intensive care unit discharge, at hospital discharge, and at 3-month follow-up. Functional status was evaluated perioperatively via Barthel index, instrumental activities of daily living, Timed Up and Go test, and functional independence measure. After exclusion of patients with intensive care unit-acquired weakness or intensive care unit stay of ≥72 hours, 59 patients were included into our analyses. Of these, 14 patients had additional pulmonary function tests preoperatively and on postoperative day 1. Blood glucose was measured intraoperatively every 20 minutes.

RESULTS:
Handgrip strength significantly decreased after surgery on postoperative day 1 by 16.4% (P < .001). Postoperative pulmonary function significantly decreased by 13.1% for vital capacity (P = .022) and 12.6% for forced expiratory volume in 1 second (P = .001) on postoperative day 1. Handgrip strength remained significantly reduced at hospital discharge (P = .016) and at the 3-month follow-up (P = .012). Perioperative glucose levels showed no statistically significant impact on muscle weakness. Instrumental activities of daily living (P < .001) and functional independence measure (P < .001) were decreased at hospital discharge, while instrumental activities of daily living remained decreased at the 3-month follow-up (P = .026) compared to preoperative assessments.

CONCLUSIONS:
Perioperatively acquired weakness occurred, indicated by a postoperatively decreased handgrip strength, decreased respiratory muscle function, and impaired functional status, which partly remained up to 3 months.
Cyberchondria and its measurement. The Polish adaptation and psychometric properties of the Cyberchondria Severity Scale CSS-PL
Authors: Bajcar Beata , Babiak Jolanta , Olchowska-Kotala Agnieszka 
Published: March 2019

Cel pracyCelem artykułu jest przedstawienie procesu adaptacji testu do pomiaru cyberchondrii (Cyberchondria Severity Scale, CSS) do warunków polskich, jak i weryfikacja wybranych miar rzetelności narzędzia i trafności teoretycznej testu.MetodaUczestnikami badania było 380 osób (203 kobiet i 177 mężczyzn) w wieku od 19 do 68 lat, (M = 26,5; SD = 11,1). Do badania wykorzystano CSS-PL do pomiaru cyberchondrii, Kwestionariusz Lęku o Zdrowie (SHAI) do pomiaru hipochondrii i Skalę Wymiarów Obsesyjno-Kompulsywnych (DOCS) do weryfikacji natężenia skłonności obsesyjno-kompulsywnych.WynikiBadanie potwierdziło czteroczynnikową strukturę cyberchondrii mierzonej skalą CSS-PL. Wskaźniki spójności wewnętrznej podskal CSS-PL uzyskały poziom: 0,87–0,95; a stabilności bezwzględnej: 0,58–0,76. Badanie wykazało trafność teoretyczną skali CSS-PL w kontekście związków cyberchondrii z lękiem o zdrowie (r = 0,31–0,56) i objawami obsesyjno-kompulsywnymi (r = 0,17–0,48).WnioskiSkala CSS-PL jest wstępną wystandaryzowaną wersją narzędzia do pomiaru cyberchondrii i spełnia kryteria psychometryczne w zakresie rzetelności i trafności testów psychologicznych. CSS-PL może być użytecznym narzędziem wykorzystywanym zarówno w badaniach diagnostycznych, jak i badaniach naukowych.
Establishing Modularized Environmental Measurements and Analyzing and Applying Environmental Information for a Windowless Broiler House in Taiwan
Authors: Li Yueh-Jung , Hsieh Kuang-Wen , Chen Suming , Lei Perng-Kwei 
Published: March 2019

Abstract. The purpose of this study was to apply wireless sensor modules to measure the environmental conditions in a windowless broiler house. An environmental index monitoring system was established that automatically estimated the temperature-humidity index (THI) and temperature-humidity-velocity index (THVI) according to the collected database. Finally, prediction of the relationships between the THI or THVI and the feed conversion rate (FCR) was studied. Nine sets of temperature, relative humidity, and wind velocity sensors were used for measuring the inside environment. An additional set was located outside the broiler house. The environmental database used this system of wireless sensors for collecting environmental information, quantifying the environmental indices, and establishing a warning system. The system automatically estimated the THI and THVI according to the database and presented the results in a user interface. Two areas of the broiler house were arranged for daily measurement of feed consumption and individual weight of the broilers for two experiments. These data were applied to calculate the daily weight gain and FCR. The first experiment was conducted from 9 September to 9 October (from summer to autumn) in 2016, and the second experiment was conducted from 3 November to 9 December (from autumn to winter) in 2016. During the experiments, there were no errors in the messages sent by the environmental database and warning system. These results serve as important references for predicting the FCR as well as the THI and THVI. The THVI of the first experiment and the THI of the second experiment predicted the FCR with a good relationship. The results show that the indoor and outdoor THI values could be higher than the standard values. In the FCR statistical analysis, the FCR of the second experiment was lower than the FCR of the first experiment, and they were both lower than the criterion FCR. This implies that opportunities exist for improving the broiler house environment in this subtropical climate. The results of this study could become an important reference for predicting the FCR with the THI and THVI. Finally, prediction of the relationships between the THI or THVI and the FCR were conducted. The results of the second experiment (R2 = 0.8327) were significantly better than the results of the first experiment (R2 = 0.5184). Keywords: Broiler, Feed conversion rate, Temperature-humidity index, Temperature-humidity-velocity index, Warning system, Wireless sensor module.
‘We’re more than just pins and dolls and seeing the future in chicken parts’: Race, magic and religion in American Horror Story: Coven
Authors: O’Reilly Jennifer 
Published: March 2019

Abstract
This article will examine intersecting representations of race, magic and religion in American Horror Story: Coven. Coven traces the presence of witchcraft and voodoo in New Orleans from the nineteenth century to the present day. The season presents two conflicting and racially divided modes of magic: the predominantly white coven who are descendants of the Salem witches and the African American voodooists, led by the most infamous voodoo queen in the United States, Marie Laveau. These two sects are sworn enemies who have competed for power in the city since the coven first arrived in New Orleans. Following a truce between the two groups, the city was divided and white and black spaces were created in which the two groups could practice their magic separately. This article will discuss the way in which Coven presents magic in the city as racially and physically segregated and will pay particular attention to the depiction of African American magical practices. This article will interrogate the ways in which Coven echoes historical accounts of Marie Laveau and how it presents the nature and function of voodoo in New Orleans. It will question in what ways Coven conforms to and deviates from established voodoo tropes, arguing that in some ways Coven perpetuates pejorative impressions of voodoo whilst disrupting others. It will argue that, through Murphy and Falchuk’s depiction of ceremonies, rituals and the voodoo deity Papa Legba, Coven sensationalizes voodoo and presents its practices as spectacle. It proposes that this contemporary image of voodoo is part of a cultural tradition established through nineteenth and twentieth century treatments of African American magic that includes depictions of black culture based on the tradition of blackface minstrelsy, Harlem Renaissance recoveries of folk traditions and popular ethnographies of the city. It will suggest that in a similar way to these historical representations, Coven draws on racialized stereotypes of the primitive and the savage to present voodoo as dark and dangerous. Yet, primarily through the figure of Marie Laveau, it will also argue that Murphy and Falchuk depict voodoo as a symbol of resistance to racialized and gendered violence and oppression, and that in many ways Coven grants agency to voodoo women. Using voodoo as a lens, this paper will address broader debates around intersecting hierarchies of race and religion, the representation of race and the visibility of black culture in America.
White coat, white alb, white mic: Institutions of truth in America in American Horror Story: Asylum
Authors: Sakal-Froese Jocelyn , Fawcett Christina 
Published: March 2019

Abstract
When Lana Winters of American Horror Story: Asylum releases footage of inhumane conditions at Briarcliff, she does so without the consent of those depicted. Her reliance on the suffering at Briarcliff to forward her own goals echoes two other key figures in Asylum: Dr Arden and Monsignor Howard. Arden’s advocacy of medical science and its potential to save humanity seem in sharp contrast to his horrific experimentation on what he sees as bare, wasted life. His position as fictional character with past experience as a Nazi doctor grounds his actions in a nexus of hyperreality and banality. Monsignor Howard believes himself a paragon of the church, whose obsessive ambitions towards Rome contrast his murderous, lustful and corrupt behaviours. He is not only complicit in Arden’s experimentation, but he takes life himself; yet, as he moves to New York as Cardinal, he looks past those abominations to focus on the greater good of the institution. In an echo of that wilful blindness, Lana is capable of looking away from the suffering of the very people she takes as an object. What makes Lana ever so slightly different from the others is her movement through the category of bare life (Agamben 1995: various) and her subsequent refusal of a ‘futurism that’s always purchased at [the] expense’ of the marginal (Edelman 2005: 4). The social institutions that the characters operate within allow and encourage their sociopathy (Asma 2009: 244–45). The danger of the institution is its capacity for creating and concealing monstrosity.
‘It’s a filthy goddamn helpless world’: Reimagining Columbine, Tate Langdon and the spectre of school shooters
Authors: McMurdo Shellie 
Published: March 2019

Abstract
You cannot watch the opening sequence of ‘Piggy Piggy’ without recalling the Columbine High School massacre of 1999, and it is these similarities that caused many media outlets to state that the series, already known for transgressive depictions of rape and murder, had ‘gone too far’. This article compares the fictional West Field High shooting with media reports of the Columbine shooting, and examines how the series reimagines the massacre – in keeping with American Horror Story’s (2011–2018) blending of the horror genre with real-life events in American history. By exploring stylistic and narrative choices made in Murder House, this article demonstrates how Tate Langdon is aligned to the perpetrators of Columbine, allowing Tate to occupy an intriguing space at the juncture between real-life trauma and fictional representation. This article details Tate Langdon’s subsequent adoption into the True Crime Community on Tumblr.com, where he often appears alongside the Columbine killers in fan products. Through an interrogation of how Tate is seen as an archetypal ‘twisted dream boy’, this article makes a connection between the depiction of Tate, the spectre of Columbine that is evoked within American Horror Story: Murder House and the under-researched area of the serial killer fandom.
Book Reviews
Authors: Burns Adam , Loranger Carol S. , Taveira Rodney , Toon Wendy 
Published: March 2019

Abstract
The History of United States Cultural Diplomacy: 1770 to the Present day, Michael L. Krenn (2017) London: Bloomsbury, 216 pp., ISBN 13 978-1-47251-001-3, p/bk, £21.99
Bitter Tastes: Literary Naturalism and Early Cinema in American Women’s Writing, Donna Campbell (2016) Athens: University of Georgia Press, xiv, 386 pp., ISBN-13 978-0-82035-468-2, h/bk, $64.95, p/bk $34.95
The Beauty of a Social Problem: Photography, Autonomy, Economy, Walter Benn Michaels (2015) Chicago: The University of Chicago Press, 240 pp., ISBN: 978-0-22642-118-6, p/bk, $24.00
The Good Occupation: American Soldiers and the Hazards of Peace, Susan L. Carruthers (2016) Cambridge, MA and London: Harvard University Press, 386 pp., ISBN 978-0-67454-570-0, h/bk, £21.95
‘Are we punks? – Yes, we drink!’: The politics of drinking in a youth subculture
Authors: Gololobov Ivan , Garifzyanova Al’bina 
Published: March 2019

Abstract
This article investigates the role of excessive drinking in a subcultural scene of Russian punk. Based on an extensive long-term field research, our work demonstrates that the loss of identity and withdrawal from the projects of social identification, usually associated with excessive consumption of alcohol, might not explain The article suggests that in certain situations drinking, disgrace, alcoholic exploits and ‘heroic incompetency’ surrounding the consumption of alcohol cause the opposite effect, through which individuals do not dissolve their identity, but rather construct alternative agency recognized and enacted within a subcultural collective. On the basis of the observations of drinking practices in three geographically defined Russian punk scenes and reflections on these practices produced by the members of the scenes, we conclude that excessive drinking can be seen as a specific response through which members of the subcultural groups construct alternative agencies and reclaim their political subjectivity.
See no colour, hear no colour, speak no colour: Problematizing colourblindness in Los Angeles punk historiography
Authors: Davila Richard Cruz 
Published: March 2019

Abstract
This article considers the collision of recent attempts to historicize punk’s complicated relationship to race with the personal investments of those ‘who were there’. In recent years, a narrative has taken hold in academic studies and museum exhibitions in which a predominantly Chicana/o punk scene coalesced in East Los Angeles, California, in the late-1970s directly in response to a supposedly closedoff Hollywood punk scene. In turn, participants in the Hollywood scene have taken umbrage at a narrative that they feel unfairly paints their scene as racist, in contrast to their own understandings of the scene as largely egalitarian. In defending their scene – and, crucially, their own legacies – against these supposedly unwarranted accusations, participants such as Brendan Mullen (1949–2009), proprietor of foundational Hollywood punk venue, the Masque, and Alice Bag, lead singer of influential band, the Bags, have employed a rhetoric of colourblindness that equates any discussion of race and racial inequality with actual racism, and that treats racism as primarily an individual character flaw rather than a systemic force. Thus, I argue, in their desire to control the history of the Hollywood punk scene, scene members such as Bag and Mullen, by attempting to discredit those whose remembrances of Los Angeles punk history clash with their own, obfuscate efforts to present a more nuanced understanding of the roles of race and racism within this history.
Diverticulosis, Symptoms and Colonic Inflammation: A Population-Based Colonoscopy Study
Authors: Järbrink-Sehgal Maria Ellionore , Rassam Loui , Jasim Aws , Walker Marjorie M. , Talley Nicholas J. , Agréus Lars , Andreasson Anna , Schmidt Peter T. 
Published: March 2019

INTRODUCTION:
Low-grade chronic inflammation has been suggested to play a role in uncomplicated asymptomatic and symptomatic diverticular disease. However, population-based studies are lacking. We investigated whether community participants with diverticulosis, with or without symptoms, would have colonic inflammation on histology and serology.

METHODS:
In a nested case–control study of 254 participants from the population-based colonoscopy (PopCol) study, colonic histological inflammatory markers and serological C-reactive protein levels were analyzed in cases with diverticulosis and controls without diverticulosis. Statistical methods included logistic and linear regression models.

RESULTS:
Background variables including age (P = 0.92), sex (P = 1.00), body mass index (P = 0.71), smoking (P = 0.34), and recent antibiotic exposure (P = 0.68) were similar between cases and controls. Cases reported more abdominal pain (P = 0.04) and diarrhea symptoms (mushy and high-frequency stools) than controls (P = 0.01 and P = 0.03, respectively) but were otherwise similar. The median C-reactive protein levels were similar among cases and controls [1.05 mg/L (0.3, 2.7) vs 0.8 (0.4, 2.2), P = 0.53]. There was a trend of increased numbers of cecal lymphoid aggregates in cases vs controls (P = 0.07), but no other associations between diverticulosis and inflammatory markers on histology were found. Similarly, no serological or mucosal inflammation was associated with symptomatic cases of diarrhea or abdominal pain vs asymptomatic controls.

CONCLUSIONS:
In a general community sample, both asymptomatic and symptomatic diverticulosis are not associated with colonic mucosal inflammation. Other explanations for symptomatic colonic diverticulosis need to be identified.
Blocked by a Ring: A Case of Gastric Linitis Plastica Presenting as Large Bowel Obstruction Secondary to Rectal Stenosis
Authors: Tariq Tooba , Turk Aijaz , Reaume Michael , Muddasani Anushareddy , Parmar Mridul 
Published: March 2019

Abstract
Metastatic gut lesions from primary gastric carcinoma occur via hematogenous, lymphatic, or peritoneal seeding. We report an unusual case of large bowel obstruction secondary to rectal stenosis due to metastatic signet ring cell gastric cancer. A 61-year-old woman with a history of 8 weeks' duration of alternation in bowel movements presented with symptoms of bowel obstruction. Computed tomography revealed rectal wall thickening, and sigmoidoscopy demonstrated edematous and fibrotic rectal mucosa. Superficial biopsies were negative for malignant disease. Because of worsening of obstructive symptoms, an emergent surgical diversion was performed. Surgical biopsies were consistent with poorly differentiated adenocarcinoma. Gastroscopy established diagnosis of gastric adenocarcinoma with signet ring type cells. Rectal stenosis on examination and demonstration of rectal wall thickening on imaging should raise suspicion for Schnitzler's metastasis, and an upper endoscopy should be performed.