bluuebunny/crossref_metadata_2025_split huggingface dataset:
A WHO 2021‐based comprehensive scheme outlining sperm parameters’ associations with IVF outcomes in PGT‐A cycles
Authors: Mazzilli Rossella , Cimadomo Danilo , Innocenti Federica , Taggi Marilena , Cermisoni Greta Chiara , Ginesi Sara , Dovere Lisa , Albricci Laura , Guido Maurizio , Campitiello Maria Rosaria , Ferrero Susanna , Capalbo Antonio , Vaiarelli Alberto , Ubaldi Filippo Maria , Ferlin Alberto , Rienzi Laura , Gennarelli Gianluca 
Published: November 2024

AbstractObjectiveTo examine the association between semen parameters, assessed according to World Health Organization (WHO)‐2021 criteria, and paternal body mass index (BMI) and age, with embryological and clinical outcomes in ICSI cycles involving preimplantation genetic testing for aneuploidy (PGT‐A).DesignRetrospective study at a private in vitro fertilization (IVF) clinic.Subjects3101 couples undergoing 4013 intracytoplasmic sperm injection (ICSI) + PGT‐A cycles with own‐oocytes (years 2013–2021).InterventionWe performed trophectoderm biopsy, and comprehensive chromosome testing to report uniform aneuploidies and vitrified‐warmed euploid single‐blastocyst‐transfers. Regression analyses adjusted for relevant confounders were conducted to outline putative associations of semen analysis and characteristics and paternal BMI and age with all embryological/clinical outcomes.ResultsMaternal age was the only significant confounding variable affecting euploidy blastocyst rate (EBR) (primary embryological outcome). When categorized, motility < 5th‐percentile (‐2.5%, 95%CI ‐4.9 to ‐0.2%, p = 0.03), concentration plus morphology < 5th‐percentile (‐2.7%,95%CI ‐4.8 to ‐0.6%, p = 0.01), concentration plus morphology plus motility < 5th‐percentile (‐4.0%,95%CI ‐5.5 to ‐2.6%, p < 0.01), obstructive‐azoospermia [OA] (‐5.5%,95%CI ‐9 to ‐2%, p = 0.02) and non‐obstructive azoospermia (NOA) (‐5.8%,95%CI ‐10.9 to ‐0.6%, p = 0.03) showed significantly lower results compared to all parameters > 5th‐percentile. Furthermore, after adjusting for maternal age and the number of metaphase‐II‐oocytes inseminated, the only significant confounding variable affecting the chance of obtaining ≥ 1 live birth among completed cycles (primary clinical outcome) was basal and post sperm processing motility. When categorized, concentration plus morphology plus motility < 5th‐percentile (multivariable‐OR: 0.73, 95%CI 0.58–0.93, p = 0.01) and OA (multivariable‐OR: 0.47, 95%CI 0.24–0.92, p = 0.03) showed significantly lower chances compared to all parameters > 5th‐percentile. Advanced paternal age (defined as > 44 years) was associated only with lower day 5‐blastocyst and Gardner's AA‐grade (i.e., top quality) blastocyst rates.ConclusionsThis comprehensive analysis provides IVF professionals with useful figures to counsel infertile couples about their chances of success, taking into account the impact of semen characteristics and paternal BMI and age. These estimates are valuable for personalized decision‐making about the most effective reproductive strategies to adopt, especially not underestimating male factor, by improving sperm concentration and motility whenever possible before assisted reproductive technologies.
‘One of the greatest injustices of our time’: The impact of social representations of modern slavery in the UK—A mixed methods approach
Authors: Haughton Melanie , Vione Katia C. , Hughes Zoe 
Published: December 2024

AbstractThis study aimed to examine how social representations of modern slavery and immigration become entangled in newspaper media. 2672 UK newspaper articles were collated from 2013 to 2022 and analysed using Content Analysis (Descendant Hierarchical Classification) and Critical Discourse Analysis (CDA). Two themes and corresponding extracts were identified from the content analysis output and analysed using CDA allowing for the exploration of the role of the hegemonic social representations to understanding how discourses of modern slavery are reproduced through the othering in relation to ethnicity and migration. The two themes that emerged were ‘Leading the way in tackling slavery’ and ‘Making claims.’ The themes combined showed how the media and political discourse positioned the UK government as leading the way in tackling modern slavery. Simultaneously, discourses criminalized migrants and constructed them as the source of social harm, and the obstacles to resolving the social injustices were those opposing anti‐immigration legislation. These two contradictory positions have implications in how modern slavery is understood by the public. More worryingly, it could lead to silence from victims due to the threat of being criminalized.
Gendered attitudes towards pro‐environmental change: The role of hegemonic masculinity endorsement, dominance and threat
Authors: Avery Robert A. T. , Kulich Clara , Thaqi Lumturie , Elbindary Aly M. A. M. K. , El Bouchrifi Hind , Favre Alexis N. J.‐L. , Gmür Simon , Hauke Sydney , Huete Chloé I. A. , Lee Si Young , Miranda Jérémy Nelson , Mizeret Zacharie , Palle Pablo , Razgallah Hédi , Theytaz Léo , Butera Fabrizio 
Published: December 2024

AbstractOne of the most robust findings in environmental psychology is that men report lower pro‐environmentalism than women. Whilst this difference is often attributed to personality or identity processes, there seems to be a lack of empirical research on potential ideological influences. We propose—and provide evidence through two correlational studies—that radical pro‐environmentalism is often akin to propositions of change that challenge tenets of patriarchal ideology such as dominance orientations. As men tend to endorse patriarchal ideologies more than women, they may perceive these challenges as more threatening, leading to greater opposition towards pro‐environmental change. In line with our hypothesis, Study 1 (N = 450, UK sample) revealed that men's (vs. women's) greater endorsement of hegemonic masculinity and threat perceptions of anticipated social change accounted for their stronger rejection of pro‐environmental policies. Study 2 (N = 254, Francophone Swiss sample) showed that men's greater endorsement of hegemonic masculinity, and higher social and ecological dominance orientation explained their higher perceptions of threat compared to women. These results highlight hegemonic masculinity as a plausible ideological framework likely to bridge previous gender gap explanations and provide policymakers with preliminary insights regarding resistance to change.
Has ChatGPT Made Economics Homework Questions Obsolete?
Authors: Faerber‐Ovaska Rachel , Ovaska Tomi , Palardy Joseph , Uppal Yogesh 
Published: November 2024

ABSTRACTWe investigate the accuracy of ChatGPT's answers to multiple‐choice and short essay questions from a widely used OER economics textbook. The questions are classified by their difficulty and cognitive level. In our tests, the bot scored a high D in multiple‐choice questions and a low A in essay questions. Most errors were found in questions of higher cognitive levels, and with calculations and graphs. While a student who has attended lectures would not gain much, if at all, from using the bot for multiple‐choice questions, the gain for a higher grade in essays is considerably larger.
A case series study on the safety of cefditoren pivoxil use during the first trimester of pregnancy in Japan
Authors: Honma Mariko , Suzuki Naoto , Goto Mikako , Obara Taku , Saito Yoshiyuki , Nakajima Ken , Yamane Ritsuko , Takahashi Kunihiko , Nakayama Takeo , Hayashi Masahiro , Murashima Atsuko , Toyama Akira 
Published: December 2024

AbstractWe evaluated the teratogenic risk associated with exposure to cefditoren pivoxil during the first trimester of pregnancy using the integrated databases of the Toranomon Hospital and the National Center for Child Health and Development. Among 13 599 registered individuals, the analysis included 285 subjects who had taken cefditoren pivoxil during the first trimester of pregnancy. The rates of stillbirth, miscarriage, and elective terminations were 0.4%, 5.6%, and 2.1%, respectively. Among 262 live births, the rates of preterm birth, low birth weight, and major congenital malformations were 4.6%, 5.7%, and 1.2%, respectively. Our results suggest that exposure to cefditoren pivoxil during the first trimester of pregnancy does not significantly increase the risk of adverse pregnancy outcomes and infant outcomes.
A 10‐Year Follow‐Up of Reconstructive Treatment of Peri‐Implantitis Using Mineralized Dehydrated Allograft and Resorbable Membrane: A Retrospective Case Series
Authors: La Monaca Gerardo , Pranno Nicola , Annibali Susanna , Polimeni Antonella , Cristalli Maria Paola 
Published: November 2024

ABSTRACTObjectivesTo evaluate the 10‐year clinical and radiographic outcomes of peri‐implantitis intrabony defects treated with mineralized dehydrated bone allograft (MDBA) and resorbable membrane in patients undergoing a regular supportive peri‐implant/periodontal therapy (STP).Materials and MethodsThe original study participants were 34 (34 defects). After mechanical debridement and chemical decontamination of implant surfaces, intrabony defects were filled with MDBA and covered by a resorbable membrane. Patients were enrolled in a maintenance program with a recall interval of 6 months. The primary outcome was the absence of additional marginal peri‐implant bone loss ≥ 1.0 mm after surgery. The composite outcome was no additional marginal peri‐implant bone loss ≥ 1.0 mm and the absence of probing depth (PD) ≥ 5 mm, bleeding on probing and suppuration.ResultsOf the original 34 implants, 20 completed the 10‐year follow‐up, and three failed. Related to the primary outcome, the mean peri‐implant marginal bone level changed from 4.78 mm (SD 1.84) at baseline to 3.10 mm (SD 1.73) after surgery and 3.71 mm (SD 1.78) at the follow‐up end point. According to the composite outcome for disease resolution, 19 of the 34 original implants were successfully treated at the 10‐year follow‐up with a statistically significant difference between 1 (31/34 implants) and 5 years (20/34 implants) (p = 0.003) and 1 and 10 years (p = 0.001) but not between 5 and 10 years (p = 1.000).ConclusionsTen years after the reconstructive treatment, followed by regular SPT, the cumulative successful treatment rate, according to the primary and the composite outcomes, was 58% (20/34 implants) and 53% (19/34) implants, respectively.
Within‐session repeatability of Doppler ultrasound leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease
Authors: Mohammad Milan , Hartmann Jacob P. 
Published: November 2024

AbstractDoppler ultrasound can be used to evaluate leg blood flow (Q̇leg), especially of interest when investigating peripheral vascular limitations in patients with chronic obstructive pulmonary disease (COPD). However, the within‐session repeatability, a subdomain of test‐retest reliability, of this method remains unknown. This study aimed to provide within‐session repeatability estimates of Doppler ultrasound‐based Q̇leg at rest and during single‐leg knee‐extensor exercise (KEE) in patients with COPD, and to compare these estimates to matched healthy controls. In this case‐controlled study, 16 participants with COPD were matched based on sex and age with 16 healthy controls. All participants underwent measurement of Q̇leg using Doppler ultrasound in a KEE setup at various intensities with the same measurement being performed again separated by 10 s. Smallest real difference (SRD) was lowest at rest in both groups and increased during exercise, reaching values ranging from 164 to 231 mL in COPD and 122–180 mL in the control group. The coefficient of variance (CV) was highest at rest and decreased during exercise to values ranging from 4.0% to 5.0% in COPD and 2.6%–3.2% in the control group. The CV was significantly lower in the control group during 0 watt and exercise at 20% of max watt, but apart from that, no reliability estimates were different between groups. To conclude, Doppler ultrasound showed nearly equal within‐session repeatability when evaluating Q̇leg in COPD patients and healthy individuals with a CV not exceeding 5% during exercise for both groups.
Influence of Acuity Circles on Hepatocellular Carcinoma and the Interaction of Gender and Race in Liver Transplantation
Authors: Manivannan Ahila , Pillai Anjana , Liapakis AnnMarie , Parikh Neehar D. , Kumar Vineeta , Verna Elizabeth C. , Salgia Reena , Wu Trueman , Lu Mei , Jesse Michelle T. 
Published: December 2024

ABSTRACTThe impact of liver transplant allocation policy using acuity circles (ACs) on interactions between race and gender on waitlist mortality or receipt of deceased donor liver transplant (DDLT) is unknown. Using data from the United Network for Organ Sharing (UNOS), we examined adults listed for DDLT from April 3, 2017, to October 4, 2022 (30 months pre‐ and post‐AC). Fine‐Gray sub‐distribution hazard model explored AC indicators by race and gender interactions and their effect on receipt of DDLT or waitlist mortality. Also explored was AC's impact on hepatocellular carcinoma (HCC) diagnosis and receipt of DDLT or waitlist mortality. 59 592 patients (30 202 pre‐AC, 29 390 post‐AC) included. For both receipt of DDLT and waitlist mortality, there were no 3‐way (AC by race by gender) interactions, indicating that the effects of race and gender on DDLT or waitlist mortality were consistent pre‐ and post‐AC. Irrespective of AC implementation, Black and Hispanic women were less likely to receive DDLT and had an increased risk of waitlist mortality compared to White women. White, Black, and Hispanic men had lower waitlist mortality risk and greater likelihood of receiving DDLT compared to their female race/ethnic counterparts. Patients with HCC had a significantly greater chance for DDLT than non‐HCC, although post‐AC this effect was attenuated. Patients with HCC were also at greater risk of waitlist mortality pre‐ and post‐AC compared to those without HCC however, the waitlist mortality post‐AC was attenuated only for those patients without HCC. To our knowledge, this is the first study to show the interaction of gender and race on waitlist mortality and access to transplantation since the implementation of AC, showing continued disparate outcomes for women both within and across racial groups.
Colloid Bodies in Cutaneous Basal Cell Carcinoma: Clinical and Histologic Correlates—An Analysis of 405 Cases
Authors: Oganesyan Ruben , Tahan Steven R. 
Published: November 2024

ABSTRACTBackgroundColloid bodies (CB), also known as Civatte bodies, are commonly seen in inflammatory dermatoses and are thought to represent cell degeneration. No studies have investigated the incidence and clinical associations of CB in cutaneous basal cell carcinoma (BCC). The aim of this study is to assess the incidence of CB in BCC lesions and analyze their clinical associations.MethodsFour hundred and five sequential cases of cutaneous BCC from 396 patients diagnosed from 1/1/2023 to 12/31/2023 in our institution were studied for the presence of CB. Only cases of BCC with a single growth pattern were included. BCC subtype, patient age, location of the lesion, history of previous BCC at other site, smoking history, and allergy history were collected. Cases with and without CB were compared for each parameter using the paired t‐test for age and the Chi‐square test for categorical data.ResultsPatients were grouped based on the presence of CB into a study group (57 cases) and control group with no CB (348 cases). CB were identified in 14% (57/405) of BCCs. 19% (54/281) of nodular, 12.5% (1/8) of infiltrative, and 1.7% (2/116) of superficial type BCCs had CB. BCC with CB were more common on the face/scalp than other sites (66.7% vs. 34.2%, p < 0.001). Patients with CB were older (median 72 vs. 68 years ±12, p = 0.04), predominantly male (63% vs. 47%, p = 0.02), more frequently had a prior BCC (0.61% vs. 0.38%, p = 0.012), and did not differ in smoking history compared to the control cohort.ConclusionsWe identified CB in 14% of BCCs studied, most commonly in nodular, followed by infiltrative, and least often superficial type. After cohort matching, significant clinical associations of CB in BCC were sun‐exposed location and personal history of one or more prior BCC at other site(s). Their pathogenesis is not known, however their presence suggests tumor regression, which may potentially be exploited for new therapies in a subset of patients.
Establishing Effective Patient Engagement Through a Terms of Reference to Foster Inclusivity and Empowerment in Research: Example From a Healthcare Transition Quality Indicators Project
Authors: Munce Sarah E. P. , John Tomisin , Luong Dorothy , Mooney Sarah , Stromquist Lisa , Chambers Kyle , Crabtree Marilyn , Diaz Sanober , Dimitropoulos Gina , Henze Megan , Higgins Amanda , Li Elaine , Severino Samadhi Mora , Penner Melanie , Pidduck Jacklynn , Wan Michelle , Williams Laura , Yates Darryl , Toulany Alene 
Published: November 2024

ABSTRACTIntroductionPatient engagement in research aims to foster meaningful partnerships, integrating patient experiences into the research process. This paper describes the development of a Terms of Reference (ToR) to support these meaningful partnerships. While engagement improves data collection and empowerment, ineffective engagement can lead to negative outcomes. A well‐developed ToR promotes a structured, inclusive, and respectful process.MethodsUsing an integrated knowledge translation (iKT) approach, we established a panel of youth, caregivers, healthcare providers, and healthcare leaders/decision‐makers. Through collaborative discussions, we incorporated key elements into the ToR, including values, roles, decision‐making processes, and recognition of contributions.ResultsTo promote effective engagement the ToR included sections to encourage open, transparent and vulnerable dialogue, evaluation, and accommodations for disabilities. The ToR draft was reviewed and refined by panel members for clarity. Regular reviews and updates will keep the ToR a living document and adaptable to the evolving engagement process.ConclusionThe implementation of our ToR is designed to foster inclusivity, mutual respect, and accountability, avoiding tokenistic partnership, enriching the experience for patients and researchers alike, and ultimately enhancing research quality.
The Impact of Technostress, Nursing Informatics Competency and Knowledge‐Sharing Behaviour on Nursing Work Performance Among Tertiary Hospital Nurses
Authors: Baek Gyuli , Lee Young Ji , Lee Eunju 
Published: November 2024

ABSTRACTAimsTo examine the impact of technostress, nursing informatics competency and knowledge‐sharing behaviour on clinical nurses' work performance.DesignA cross‐sectional study.MethodWe recruited nurses with over 6 months of experience from three tertiary hospitals in Daegu, Korea. Nurse managers and higher administrative positions were excluded. Participants completed an online questionnaire measuring technostress, nursing informatics competency, knowledge‐sharing behaviour and nursing work performance. Data were collected from December 20 to 29, 2023, and analysed using SPSS/WIN 24.0 with descriptive statistics, t‐tests, ANOVA, Pearson's correlation coefficient, multiple regression and the Scheffe test.ResultsFactors affecting nursing work performance included subfactors of nursing informatics competency— information ethics (β = 0.26, p < 0.001), problem clarification (β = 0.21, p = 0.003), information retrieval (β = 0.19, p = 0.002), information integration (β = 0.19, p = 0.003) and subfactors of technostress, namely techno‐complexity (β = −0.20, p = 0.001) and techno‐overload (β = −0.15, p = 0.007). These variables explained 62% of the variance in nursing work performance.ConclusionNursing informatics competency and technostress significantly influence nursing work performance. Despite the regional limitation, our findings underscore the need to enhance informatics competency and mitigate technostress to improve nursing performance. Future studies should broaden the population scope and validate these results. System‐level interventions, such as technology education for nurses, can reduce technostress, thereby improving nursing work performance.ImpactThis study suggests that nursing informatics competency and technostress are crucial for nursing work performance, quality of care and public health enhancement.Public ContributionNo patient or public contribution.
The Influence of Participation in an Intensive Care Trial on Health Practitioners' Knowledge of the Results—A Self‐Reported Survey
Authors: Mackle Diane M. , Nelson Katherine , Beasley Richard W. , Eathorne Allie , Young Paul J. 
Published: November 2024

ABSTRACTAimThe Intensive Care Unit Randomised Trial Comparing Two Approaches to Oxygen Therapy Trial (ICU‐ROX) compared conservative oxygen therapy with usual care in mechanically ventilated adults in Australian and New Zealand intensive care units. Dissemination focused on publication and presentation, with no targeted approach.The current study aimed to

investigate whether health practitioners from intensive care units that participated in ICU‐ROX were more likely to report they knew the trial results and had read the publication than those from intensive care units that did not participate;
explore whether there was a difference between doctors' and nurses' knowledge of the ICU‐ROX results and whether they read the publication.
DesignSurvey using a self‐administered, quantitative design, developed for this study.MethodsConvenience sample of 197 Australian and New Zealand intensive care specialist doctors and nurses.ResultsThere was no difference in the knowledge of the study results between respondents from intensive care units that participated in ICU‐ROX compared to those that did not. Nurses were significantly less likely to have knowledge of the trial results or have read the publication than doctors. The commonest way for doctors and nurses to get the results was by word of mouth at work.ConclusionsParticipation in ICU‐ROX did not make a difference to knowledge of the findings. While the dissemination of trial results was extensive, it failed to adequately reach nurses, who play an important role in administering oxygen in intensive care.ImpactThis study has provided further evidence that nurses working in intensive care were unlikely to read the research results of an important study about oxygen management.Implications for the Profession

Researchers, unit management and nurse leaders need to ensure dissemination methods that will reach nurses are used for research findings.

Reporting MethodThis study followed the STROBE reporting guidelines for observational studies.Patient or Public ContributionNo patient or public contribution.Trial RegistrationThis study is a substudy of a trial that was prospectively registered before the first participant was recruited: ACTRN12615000957594