bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the Roles of New Antiepileptic Drugs and Serum BDNF Levels in Efficacy and Safety Monitoring and Quality of Life: A Clinical Research
Authors: Demir Meral , Akarsu Emel O. , Dede Hava O. , Bebek Nerses , Yıldız Sevda O. , Baykan Betül , Akkan Ahmet G. 
Published: March 2019

Objective:
We aimed to determine the therapeutic drug monitoring (TDM) features and
the relation to Brain-Derived Neurotrophic Factor (BDNF) of frequently used new antiepileptic
drugs (NADs) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide
(LCM). Moreover, we investigated their effect on the quality of life (QoL).

Methods:
Eighty epileptic patients who had been using the NADs, and thirteen healthy participants
were included in this cross-sectional study. The participants were randomized into groups. The
QOLIE-31 test was used for the assessment of QoL. We also prepared and applied "Safety Test".
HPLC method for TDM, and ELISA method for BDNF measurements were used consecutively.

Results:
In comparison to healthy participants, epileptic participants had lower marriage rate
(p=0.049), education level (p˂0.001), alcohol use (p=0.002). BDNF levels were higher in patients
with focal epilepsy (p=0.013) and in those with higher education level (p=0.016). There were negative
correlations between serum BDNF levels and serum ZNS levels (p=0.042) with LTGpolytherapy,
serum MHD levels (a 10-monohydroxy derivative of OXC, p=0.041) with OXCmonotherapy.
There was no difference in BDNF according to monotherapy-polytherapy, drugresistant
groups, regarding seizure frequency. There was a positive correlation between total health
status and QoL (p˂0.001). QOLIE-31 overall score (OS) was higher in those with OXCmonotherapy
(76.5±14.5). OS (p˂0.001), seizure worry (SW, p=0.004), cognition (C, p˂0.001),
social function (SF, p˂0.001) were different in the main groups. Forgetfulness was the most common
unwanted effect.

Conclusion:
While TDM helps the clinician to use more effective and safe NADs, BDNF may assist
in TDM for reaching the therapeutic target in epilepsy.
Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period
Authors: Fedakâr Atiye 
Published: March 2019

Objective:Maternal vitamin D deficiency is an important risk factor that causes infantile rickets in the neonatal and infantile period. The aim of this study was to review the prevalence, clinical characteristics, and treatment of vitamin D deficiency and the follow-ups with infants and their mothers by the neonatal intensive care unit of Afiyet Hospital in Turkey.Methods:Calcium (Ca), phosphorus (P) and 25 (OH) vitamin D were studied and prospectively recorded in infants and their mothers detected to have hypocalcemia during routine biochemistry tests performed on the third postnatal day of the patients follow up and treated with different diagnoses.Results:A total of 2,460 infants were admitted into the neonatal intensive care unit between August 2014 and January 2018. Of the infants included in the study, 324 (66.1%) were male and 166 (33.8%) were female, and 366 (74.6%) of them had been delivered by cesarean section (C/S), 124 (25.3%) of them had been delivered by Normal Spontaneous Delivery (NSD). Hypocalcemia was detected in 490 (19.9%) of the infants. In a total of 190 (38.7%) infants and 86 mothers (17.5%), the levels of 25 (OH) vitamin D were found to be below the laboratory detection limit of <3 ng/ml. When vitamin D deficiency + insufficiency is assessed by season, 151 of them were found to be in summer (30.99%), 118 in spring (24.18%), 117 in the winter season(23.87%), and 93 in autumn(18.97%), respectively. There was a statistically significant positive correlation of 78.7% between the vitamins D values of the mothers and the infants (p: 0.000, p<0.05).Conclusion:This study conducted that a positive correlation of between the vitamin D values of the mothers and the infants. In order to prevent maternal vitamin D deficiency, the appropriate dose of prophylaxis providing optimal levels of vitamin D and should be given by according to the levels of 25 (OH) D vitamin during pregnancy.
A Study on Effect of Sol Aging Time on Optical Properties of ZnO Thin Films: Spectroscopic Ellipsometry Method
Authors: Aghkonbad Ehsan Motallebi , Aghgonbad Maryam Motallebi , Sedghi Hassan 
Published: March 2019

Background:
Due to wide band gap and large excitonic binding energy, being inexpensive,
abundance in nature and easy synthesis ZnO is a promising candidate in many applications such as solar
cells.

Experimental:
In the current work a series of ZnO thin films were deposited on glass substrates using
sol-gel method to investigate the change in optical behavior of the film with sol aging time (asprepared,
8, 16, 24 and 32 hours) and the annealing temperature (300ᵒC and 500ᵒC). The optical properties
of thin films were explored using spectroscopic ellipsometry method including the real and imaginary
part of refractive index, real and imaginary part of dielectric function and band gap energy of
the layers in the 300-900 nanometer wavelength range.

Results:
It can be deduced from the results that sol aging time and annealing temperature, affect the optical
properties of the samples. Using single oscillator energy model of Wemple and Di Domenico parameters
such as free charge carrier concentration ratio to effective mass, and plasma frequency, were calculated.

Conclusion:
The films prepared using 24 h aged solution, had the highest transmittance and the largest
band gap energy.
Burrows Wheeler Transform and Wavelet Tree Based Retrieval of Genome Sequence in an Indexed Genome Database
Authors: Kumar Sanjeev , Agarwal Suneeta , Ranvijay  
Published: March 2019

Background:
New generation sequencing machinery such as Illumina and Solexa can
generate millions of reads from given genome sequence on a single run. There is a need for suitable
data structure, efficient with respect to memory as well as time to align these enormous reads into
reference genome. There are a number of existing techniques of indexing and reads alignment, such
as MAQ, Bowtie, BWA, BWBBLE and Kart. Memory efficient versions of these techniques are 10-
20% slower than their respective normal versions.

Objective:
A new approach for efficient indexing and retrieval of large genomic data.

Methods:
In this paper, we propose an efficient method based on Burrows Wheeler Transform and
Wavelet Tree (BWIT) for genome sequence indexing and reads alignment. Both types of alignments
(exact and approximate) are possible by the proposed approach (BWIT).

Results:
The performance of BWIT is experimentally found to be better than existing ones with respect
to both memory and speed. Experimental work shows that proposed approach performs best in
case of protein sequence indexing. All the existing read alignment approaches depend upon the size
of index used. In general, time required increases with reduction in index size used. Experiments
have been done with Bowtie, BWA & Kart by taking index size as 1.25N, 1.05N, .98N, where N is
the size of the text (reference genome). In our approach BWIT index size is .6N which is lesser than
index size used in all other approaches. It is observed that even using smallest index size alignment
time in our approach is least.

Conclusion:
An innovative indexing technique is presented to address the problem of storage,
transmission and retrieval of large DNA/Protein Sequence data.
Codeine Addiction and Internet Forum Use and Support: Qualitative Netnographic Study
Authors: Lee Eleanor , Cooper Richard J 
Published: March 2019

Background
The use of codeine as an analgesic is well-recognized, but there are increasing concerns that for some individuals continued use may lead to misuse, dependence, and fatalities. Research suggests that those affected may represent a hard-to-reach group who do not engage with formal treatment services.

Objective
This study sought to explore the experiences of people with self-reported addiction to codeine and, specifically, how a social media forum is used to communicate with others about this issue.

Methods
Using a qualitative netnographic methodology, the social media forum Mumsnet was used, with permission, and searches were undertaken in 2016 of any posts that related to codeine and addiction. A total of 95 relevant posts were identified; a purposive sample of 25 posts was selected to undertake subsequent six-stage thematic analysis and development of emerging themes. These 25 posts were posted between 2003 and 2016 and comprised 757 individual posts.

Results
Individuals created posts to actively request help in relation to usually their own, but occasionally their partner’s or relative’s, problems relating to codeine use and self-reported “addiction.” Varying levels of detail were provided in narratives of problematic codeine use. There were both positive and negative descriptions of side effects emerging, problems experiencing withdrawal, and failed attempts to discontinue codeine use. Mainly positive and supportive responses to posts were identified from those with either self-reported health profession experience or lay respondents, who often drew on their own experiences of similar problems. Treatment advice emerged in two main ways, either as signposting to formal health services or to informal approaches and often anecdotal advice about how to taper or use cold turkey techniques. Some posts were more critical of the original poster, and arguments and challenges to advice were not uncommon. Shame and stigma were often associated with users’ posts and, while there was a desire to receive support and treatment advice in this forum, users often wanted to keep their codeine use hidden in other aspects of their lives. Distinctly different views emerged as to whether responsibility lay with prescribers or patients. Some users expressed anger toward doctors and their prescribing practices.

Conclusions
This study provides a unique insight into how a public internet forum is used by individuals to confirm and seek support about problematic codeine use and of the ways others respond. The pseudonymous use of internet forums for such information and variation in treatment options suggested by often lay respondents suggest that increased formal support and awareness about codeine addiction are needed. There may be opportunities for providing further support directly on such online forums. Improvements in prescribing codeine and in the over-the-counter supply of codeine are required to prevent problematic use from occurring.
Pelatihan “Action” untuk Meningkatkan Keterampilan Stimulasi Literasi pada Guru TK
Authors: Utari Zahra Santika , Martani Wisjnu 
Published: March 2019

Abstract. This study aims at examining the influence of “ACTION” training on improvement of kindergarten teachers’ skills of literacy stimulation. “ACTION” training is a training provided for teachers as scaffolder by using activities of sociodrama to improve literacy stimulation skills. The design employed in this study is untreated group control design with dependent pretest and posttest samples. The subjects of the research are 18 kindergarten teachers (9 teachers in experimental group and 9 teachers in control group). The research instruments used are “ACTION” training module, observation guide for literacy stimulation skills, knowledge test of literacy stimulation, and knowledge test sociodrama activity. The statistical test uses Mann-Whitney U Test. The results of the study show that stimulation literacy skills are significantly higher in experimental group than in control group (U = 0,000; p < 0,05). This study concludes that “ACTION” training can improve kindergarten teachers’ skills of literacy stimulation. Keywords: kindergarten teacher; literacy stimulation; sociodramatic play
“Kepedulian terhadap Sahabat” untuk Meningkatkan Perilaku Prososial Saksi Bullying di Tingkat Sekolah Menengah Pertama
Authors: Apriliawati Reni , Purnamaningsih Esti Hayu 
Published: March 2019

Abstract. This study aimed to test the effect of training module “Kepedulian terhadap sahabat” in improving prosocial behavior of peer bystanders in middle school. This research used quasi experiment method with the untreated control group design with dependent pretest and posttest samples which separated subjects into two groups, experimental group and control group (N: 48). The subjects were bullying bystanders grade 7-8 middle school students. Instrument used in this research were knowledge test as manipulation check, prosocial scale, and a module of “Kepedulian terhadap Sahabat”. T-test was used to analyze the difference between experimental group and control group. The result shows of that “Kepedulian terhadap Sahabat” has an effect bystanders’s prosocial behavior (z=-3.799, p=0.01) on middle schoolstudents. Keywords: bullying bystanders; prosocial behavior; social-emotional learning
¿De quién es la diplomacia pública? El rol del Departamento Autónomo de Prensa y Publicidad (DAPP) en la propaganda exterior cardenista
Authors: Dümmer Scheel Sylvia 
Published: March 2019

<p>El artículo explora el rol que tuvo el Departamento Autónomo de Prensa y Publicidad, creado por Lázaro Cárdenas para unificar todas las labores de propaganda estatal bajo un solo organismo centralizado, sobre la diplomacia pública de México entre 1937 y 1939. Debido a que su creación vino a interrumpir la larga labor que, en ese ámbito, realizaba la Secretaría de Relaciones Exteriores, el análisis se centra en la interrogante de sobre cuál organismo debiera recaer la propaganda exterior de la nación, ¿sobre aquél que se encarga de las comunicaciones del gobierno, o sobre la dependencia responsable de las relacionas internacionales del país? Para ello, se profundiza especialmente en el desafío que representó para el DAPP considerar la mediación cultural que requiere la diplomacia pública, y en los esfuerzos de la SRE por mantener cierto control sobre dicha labor. </p>
Pemodelan Direct Quadrate (D-Q) Pada Kendali Kecepatan Motor Induksi Tiga Phasa dengan Field Oriented Control (FOC) Berbasis Kendali P-I
Authors: Fauzi Rizana , Khair Jumaddil 
Published: March 2019

The utilization of a 3 phase induction motor is increasingly developing, so research on speed regulation in 3 phase induction motors is also increasingly widely studied. This is because the use of 3 phase induction motors in the industry and especially hybrid vehicles are increasingly being developed. But there are some disadvantages of induction motors, one of which is the characteristics of non-linear parameters, especially rotor resistance which has varying values for different operating conditions, so it cannot maintain its speed constantly if there is a change in load. This, of course, can affect the performance of an induction motor. To get a constant speed and better system performance on load changes a controller is needed. This study aims to model direct-quadrate parameters (D-Q) using the Field Oriented Control (FOC) method based on the Proportional-Integral (PI) controller. With the d-q parameter controlled, the induction motor will be more stable, because the d-q parameter determines the stability of the change in torque and flux in the induction motor. Proportional-Integral (PI) control used is a classic control system that is easy because it does not need to look for a mathematical model of the system, but it remains effective because it has a fairly stable system response, by setting the best combination of proportional (Kp) constants and Integrator constants ( Ki). In the results of the implementation, it can be seen that the use of FOC can be used as an approach in terms of setting the speed of the induction motor, and with the use of the PI control can help the output response get better with a shorter response time to reach the reference value.
The Moderating Role of Internal Control in Tax Avoidance: Evidence from a COSO-Based Internal Control Index in China
Authors: Chen Hanwen , Yang Daoguang , Zhang Xinmin , Zhou Nan 
Published: March 2019

ABSTRACT
We study the role of internal control in tax avoidance by evaluating the efficacy of the COSO framework in tax risk management. First, we use a comprehensive COSO-based index in China that covers a firm's internal control over not only financial reporting, but also operations and compliance. Second, we perform quantile regressions to account for the entire tax avoidance distribution. These two key features enable us to find a nonlinear relation between internal control and tax avoidance, with the former having a moderating effect on the latter. Specifically, we show that internal control quality enhances tax avoidance for under-sheltered firms but curbs tax avoidance for over-sheltered firms. This nonlinear pattern continues to hold when we decompose internal control into its five COSO components. Moreover, the moderating role of internal control in tax avoidance alleviates tax volatility, supporting the accounting firms' recommendation to use COSO-based internal control in tax risk management.
JEL Classifications: H26; G32; M42.
Membangun Quality Function Deployment Untuk Meningkatkan Kepuasan Pasien Pada Rumah Sakit Di Kota Tegal
Authors: Sujarwo Makmur , Subekti Subekti 
Published: March 2019

Abstract: This study aims to find out how far the Quality Function Deployment (QFD) strategy is built in hospitals in the city of Tegal so that it can improve patient satisfaction. This study uses a questionnaire distribution method with a sample of 120 hospital patients in the city of Tegal as respondents. Respondents' answers to closed questions about the variables examined in this study were then analyzed using Multiple Regression Tests with IBM SPSS Statistics 22 analysis. The results of this study indicate variebel tangibles and emphaty which have a positive and significant effect on increasing patient satisfaction with successive regression values according to 0.340 and 0.559. For that reason, it has become a necessity for the hospital to further increase the tangible and empathetic of its patients in order to increase patient satisfaction. In the Quality Function Deployment (QFD) application, it shows that most of the requirements of patients (consumers) get value is very important and only a few who get important ratings, among others; rapid patient handling, the availability of sophisticated and modern hospital equipment technology; employees, nurses and doctors who are experts competent in their fields and friendly in serving patients, and others. Keywords : Quality Function Deployment, tangibles, reliability, responsiveness, assurance dan emphathy.. Abstraksi:Penelitian ini bertujuan untuk mengetahui sejauh mana strategi Quality Function Deployment (QFD) dibangun di rumah sakit di kota Tegal sehingga dapat meningkatkan kepuasan pasien. Penelitian ini menggunakan metode distribusi kuesioner dengan sampel 120 pasien rumah sakit di kota Tegal sebagai responden. Responden terhadap pertanyaan tertutup tentang variabel dianalisis menggunakan Uji Regresi Berganda dengan analisis IBM SPSS Statistics 22. Hasil penelitian ini menunjukkan variableness dan empati yang memiliki pengaruh positif dan signifikan terhadap peningkatan kepuasan pasien dengan nilai regresi berturut-turut sesuai 0,340 dan 0,559. Oleh karena itu, menjadi lebih penting bagi pasien untuk meningkatkan kepuasan pasien. Dalam aplikasi Quality Function Deployment (QFD), itu menunjukkan kondisi yang paling penting bagi pasien (konsumen), antara lain; penanganan pasien yang cepat, ketersediaan teknologi peralatan rumah sakit yang canggih dan modern; karyawan, perawat dan dokter yang ahli dalam bidangnya dan ramah dalam melayani pasien, dan lainnya.Kata kunci : Quality Function Deployment, tangibles, reliability, responsiveness, assurance dan emphathy.
POLA REHABILITASI ISLAMI BAGI PECANDU NARKOBA DI BADAN NARKOTIKA NASIONNAL PROVINSI RIAU: PERSPEKTIF KONSELING ISLAM
Authors: Zulamri Zulamri 
Published: March 2019

Kesesuaian pola rehabilitasi dan teknik yang diberikan pada pasien harus memiliki kesesuaian dengan kondisi pasien yang diantaranya adalah faktor kultur tempat individu berkembang, namun dalam konteks penerapannya di Indonesia yang mayoritas penduduknya Islam. Pada dasarnya proses dan teknik rehabilitasi Islam ada tiga tahap yaitu tahap pembersihan diri, pengembangan diri, dan penyempurnaan diri, ketrampilan dan keahlian tidak akan datang dan bertambah dengan sendirinya tanpa adanya suatu latihan-latihan. Napza, yang merupakan singkatan dari Narkotika,Psikotropika dan Zat Adiktif merupakan jenis bendayang menjadikan orang yang mengkonsumsunya mabuk, sehingga merusak akal dan psikis serta organ-organ tubuh lain. Penelitian ini dilakukan di Badan Narkotika Nasional (BNNP) Provinsi Riau yang responden penelitian ini adalah pengelola dan konselor dengan cara memperoleh langsung data dari responden melalui informasi dari wawancara dan kuesioner yang dilakukan serta dokumentasi. Analisis data menggunakan metode deskriptif, yaitu menguraikan fakta yang diperoleh kemudian dihubungkan dengan teori yang ada dan diinterpretasikan untuk memperoleh makna dan implikasi hubungan yang ada. Hasil dari penelitian ini yaitu pola rehabilitasi islam pencandu narkoba di BNNP Provinsi Riau perspektif islam merupakan bagian integral dalam program pemulihan bagi residen di BNNP Provinsi Riau. Dalam proses pola rehabilitasi kebanyakan residen tidak bisa diharapkan untuk menyelesaikan masalahnya sendiri. Sehingga diperlukan suatu upaya bantuan guna membantu residen dalam proses pemulihannya, yaitu salah satunya dengan menanamkan nilai-nilai islami di dalam diri pecandu narkoba.
MANAJEMEN PELAYANAN SOSIAL DI LEMBAGA PANTI ASUHAN HASANA PEKANBARU
Authors: Kodarni Kodarni 
Published: March 2019

Penelitian ini bertujuan untuk berusaha memahami arti peristiwa dan kaitan-kaitannya dalam situasi tertentu dari perilaku seseorang atau penyelenggara manajemen pelayanan sosial di lembaga Panti Asuhan hasana, serta melakukan kegiatan manajemen tersebut dengan menggunakan metode penelitian kualitatif Fenomenologi.Panti Asuhan Hasana merupakan salah satu panti asuhan hasana secara manajemen sangat baik, tertata dan terkelola sehingga menjadi panti asuhan hasana yang dapat dicontoh di kota pekanbaru. hasil penelitian sebagai berikut:pertama, Perencanaan dilakukan sebelum pelaksanaan kegiatan pelayanan sosial kepada anak di panti, sedangkan seluruh civitas akademika. Keterlibatan seluruh unsur dalam perencanaan menjadi hal yang sangat penting baik yang dibuat diawal tahun ajaran baru, pemberian bimbingan dan arahan kepada anak asuh, pertengahan semester, mingguan bahkan harian. Selalu diawasi baik oleh pengurus panti maupun oleh guru yang mengajar. Kedua, Pengorganisasian yang dilakukan antar unit yang ada atau antar lintas kelas sesuai dengan prosedur pelayanan sosial, mulai dari identifikasi sampai pada intervensi dan tindak lanjut. .Ketiga, Pelaksanaan yang dilakukan dalam berbagai aktivitas rutin di lembaga baik di kelas proses pembelajaran, di luar lembaga pada event tertentu, penggunaan metode sampai keadministrasian berjalan dengan baik. Sesuai prosedur pelayanan sosial yang dilakukan. Keempat, Pengawasan dilembaga Panti Hasanah dalam hal evaluasi berbagai kegiatan sesuai dengan pelaksanaan yang dilakukan dan rencana yang telah dilakukan seperti persiapan dan pelaksanaan proses pembelajaran di kelas maupun antar lembaga melibatkan seluruh civitas akademika yayasan, baik yayasan, kepala sekolah, guru orang tua wali murid bahkan keterlibatan anggota masyarakat.