bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Knowledge-Enriched Computational Model to Support Lifecycle Activities of Computational Models in Smart Manufacturing
Authors: Zhang Heng , Roy Utpal 
Published: November 2018

Abstract
Because of the needs in developing industrial community modeling and simulation platforms for smart manufacturing, a Knowledge-Enriched Computational Model (KECM) is proposed in this article to formally capture domain knowledge and integrate that knowledge with standardized computational models. To support model development in a distributed environment, the KECM can be used as the medium for formal information sharing between model developers. A case study has been developed to demonstrate the utilization of the KECM in supporting the construction of a Bayesian Network model between a domain expert and data analyst. To support model deployment, a general method to support the integration of computational models into a manufacturing data system has been presented. A case study has been developed to show the data integration of an optimization model into a Business To Manufacturing Markup Language-based manufacturing system. Finally, a general model to support the combination of computational models have been presented. A case study has been developed to show the combination of an Agent-based model and a Decision Tree model using the KECM.
INTERVENÇÃO SOCIAL DO EMPRESARIADO E A REFORMA DO ESTADO BRASILEIRO
Authors: Noronha Jardim Tânia Horsth 
Published: November 2018

O presente artigo pretende levantar o debate sobre a intervenção social do empresariado, através da entrada em cena do fenômeno da responsabilidade social no terreno empresarial, destacando três acontecimentos emblemáticos que marcam a emergência do fenômeno no Brasil: o Prêmio ECO[1] (1982), a fundação do Pensamento Nacional das Bases Empresariais (PNBE), em 1987, e do Grupo de Institutos e Fundações Empresariais (GIFE), em 1995. Partimos do pressuposto que estes programas abarcam uma proposta de ação social empresarial direcionada para um projeto hegemônico de sociedade, centrada no mercado, e que decorre da Reforma do Estado Brasileiro implementada na década de 1990.

[1] Assim denominado pelo significado da palavra: ressonância, repetição de um som emitido, propagação ou disseminação de uma ideia.
Factors of Loss to Follow-up Antiretroviral Therapy in Islanded Area
Authors: Boro Thomas Laga , Paun Rafael , Pellokila Marthen R 
Published: November 2018

ABSTRACT
Loss to follow-up of antiretroviral therapy is when PLWHA (People Living with HIV/AIDS) do not come for antiretroviral therapy for more than 3 months. This study aimed to determine the factors of loss to follow-up antiretroviral therapy for PLWHA at Prof. Dr. W. Z. Johannes Kupang Public Hospital where PLWHA with land, water and air transportation are served. This was a case control study with 66 samples of PLWHA. The samples underwent antiretroviral therapy in Prof. Dr.W.Z. Johannes Kupang Public Hospital from 2006 to 2016. Saturated sampling technique was done for cases group and simple random sampling was done for control group. Univariate and bivariate data analysis were done in this study. The result of bivariate analysis showed that there were association between intention (p = 0.004, OR = 4.667), self efficacy (p = 0.0001, OR = 7.875), action (p = 0.0001, OR = 45.000), transportation mode (p = 0.046, OR = 0.200), and transport costs (p = 0.0001, OR 19.333) and loss to follow-up antiretroviral therapy. It could be concluded that transportation and behavior were the major problems for the loss to follow up antiretroviral therapy in the islanded area.

Keywords: HIV/AIDS, antiretroviral therapy, loss to follow-up, islanded area

ABSTRAK
Gagal follow-up antiretroviral therapy adalah jika ODHA (Orang dengan HIV/AIDS) tidak menjalani terapi antireroviral lebih dari 3 bulan terakhir. Penelitian ini bertujuan untuk mengetahui faktor-faktor gagal follow-up antiretroviral therapy pada ODHA di RSUD Prof. Dr. W. Z. Johannes Kupang yang melayani para ODHA dengan moda transportasi darat, air, dan udara. Desain penelitian ini adalah case control. Sampel sebanyak 66 ODHA yang menjalani antiretroviral therapy di RSUD Prof. Dr.W.Z. Johannes Kupang sejak tahun 2006 sampai 2016. Teknik pengambilan sampel yang digunakan adalah sampel jenuh untuk kelompok kasus dan simple random sampling untuk kelompok kontrol. Analisis data menggunakan prosentase untuk univariat dan bivariat. Hasil analisis bivariat menunjukkan ada pengaruh niat (p = 0,004, OR = 4,667), self efficacy (p = 0,0001, OR = 7,875), tindakan (p = 0,0001, OR = 45,000), moda transportasi (p = 0,046, OR = 0,200), dan biaya transportasi (p = 0,0001, OR 19,333) terhadap gagal follow up terapi antiretroviral. Dapat disimpulkan bahwa masalah utama gagal follow up terapi antiretroviral di wilayah berkepulauan ini adalah transportasi dan perilaku.

Kata Kunci: HIV/AIDS, terapi antiretroviral, gagal follow up, wilayah berkepulauan.
OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices
Authors: Xiong Zhi , Zhang Qingrun , Platt Alexander , Liao Wenyuan , Shi Xinghua , de los Campos Gustavo , Long Quan 
Published: November 2018

AbstractMatrices representing genetic relatedness among individuals (i.e., Genomic Relationship Matrices, GRMs) play a central role in genetic analysis. The eigen-decomposition of GRMs (or its alternative that generates fewer top singular values using genotype matrices) is a necessary step for many analyses including estimation of SNP-heritability, Principal Component Analysis (PCA), and genomic prediction. However, the GRMs and genotype matrices provided by modern biobanks are too large to be stored in active memory. To accommodate the current and future “bigger-data”, we develop a disk-based tool, Out-of-Core Matrices Analyzer (OCMA), using state-of-the-art computational techniques that can nimbly perform eigen and Singular Value Decomposition (SVD) analyses. By integrating memory mapping (mmap) and the latest matrix factorization libraries, our tool is fast and memory-efficient. To demonstrate the impressive performance of OCMA, we test it on a personal computer. For full eigen-decomposition, it solves an ordinary GRM (N = 10,000) in 55 sec. For SVD, a commonly used faster alternative of full eigen-decomposition in genomic analyses, OCMA solves the top 200 singular values (SVs) in half an hour, top 2,000 SVs in 0.95 hr, and all 5,000 SVs in 1.77 hr based on a very large genotype matrix (N = 1,000,000, M = 5,000) on the same personal computer. OCMA also supports multi-threading when running in a desktop or HPC cluster. Our OCMA tool can thus alleviate the computing bottleneck of classical analyses on large genomic matrices, and make it possible to scale up current and emerging analytical methods to big genomics data using lightweight computing resources.
O movimento feminista no Brasil sob a ótica do Behaviorismo radical
Authors: Sousa dos Santos Luana , Valverde Mirella Hoschette Dearo , Rubio Adriana Regina 
Published: November 2018

O presente estudo teve por objetivo analisar o movimento feminista no Brasil sob a ótica do Behaviorismo Radical. Observa-se que contingências de reforço mantidas por um grupo podem ser denominadas contingências culturais e caracterizam-se num nível de seleção pelas consequências - o nível de seleção cultural que fora proposto por F.Skinner a fim de compreender melhor o ser humano, completando as indagações que não podiam ser respondidas adequadamente pela seleção natural (ou filogenia) e a seleção operante (ontogenia). Assim, é possível compreender que o movimento feminista é uma prática cultural composta de metacontingências, em que há contingências entrelaçadas com recorrência envolvidas. Com estas concepções foi é possível analisar que o movimento feminista possibilitou mudanças nas práticas culturais do Brasil. Mudanças que envolvem diversas áreas de atuação da mulher: seja na esfera familiar, política e do mercado de trabalho.
Filling the Frame: Photography of May Day Crowds during the Early Nazi Era
Authors: Conze Linda 
Published: November 2018

Filling the Frame: Photography of May Day Crowds during the Early Nazi Era When one thinks of festive crowds under National Socialism, the state-orchestrated events at Berlin's Tempelhofer Feld, the Bückeberg or at the Reichsparteitagsgelände in Nuremberg are what first come to mind. But apart from the huge festival grounds, festive crowds also came together on sports fields and town squares all over Germany. They were certainly smaller in number, yet the presence of the many was clearly also of great ritual importance in small towns and rural communities. Whenever they came together, a camera was there to document. It is especially in forms of representation that the crowd becomes negotiable. Stories of crowds unfold along images. The article examines the role of photographs of crowd scenes in the process of community-formation during the early Nazi era when the idea of a racially defined Volksgemeinschaft was ubiquitous throughout the German Reich. It focuses primarily on the particular importance of photography as a means of negotiating, adapting and transforming social affiliation. Also addressed is the overall relationship between photography and the masses. Inspired by Elias Canetti's typology of crowds, a comparison of state-controlled and local depictions of May Day festivities reveals a variety and ambivalence of photographic representations of crowds during the early 1930s, which has been overlooked by historic research so far. A surprising visual openness made the crowd images adaptable to traditional ideas of community as well as able to respond to the need to position oneself in the new social framework.
National in Front of the Camera, Soviet Behind It: Central Asia in Press Photography, 1925–1937
Authors: Holzberger Helena 
Published: November 2018

National in front of the Camera, Soviet behind it: Central Asia in Press Photography, 1925–1937 While photography in early Soviet Union is a well-researched field, researchers addressed hitherto mostly Soviet Russia. The history of photography in the Central Asian Soviet Republics, though, lacks research. This article focuses on the means of production and distribution of photographs taken in Uzbekistan 1926–1937. With Roland Barthes theory of «connotation», it interprets the visual invention of the Soviet Orient. Photographs by Georgij Zel'ma and Maks Penson of Uzbekistan that were published in Soviet mass media are analyzed, determining style, content and function. Through additional textual analysis, I discuss the network of photographers on the periphery and image agents on the centre. Socialist connotations are derived from appropriations of pre-revolutionary photographs accompanied by false textual framing, innovative compositions of ethnographic images and combinations of local cultural symbols with Soviet modernity. As photographers, primarily from Moscow, travelled to Central Asia, they greatly dominated its visual depiction. Although they emphasized Soviet modernity, they also reproduced older stereotypes about the Orient. Besides offering a history on photography, this article also discusses the establishment of Soviet cultural structures between the centre and the periphery as well as the subordinated agency of local actors at the periphery.
The Dictator's Photo Albums: Photography under the Metaxas Dictatorship
Authors: Soursos Nathalie Patricia 
Published: November 2018

The Dictator's Photo Albums: Private and Public Photographs in the Metaxas-Dictatorship The Greek authoritarian «Fourth of August Regime» (1936–1941) focussed in its propaganda on promoting the dictator Ioannis Metaxas as father, grandfather and «First peasant» and while in foreign policy the close ties to the Balkan Entente was advertised, the transfer of ideas from the European fascist regimes was negated. By examining 57 photo albums preserved today in the Hellenic Parliament Archives the article discusses photo albums as a source for the interpretation of the Metaxas dictatorship and as a source for the history of photography in Greece. It examines the private photo album aesthetics and its use in three official brochures with an exceptional high amount of photographs: Fourth of August 1936–1938, Fourth of August 1938–1939 and Four Years of Government by I. Metaxas, 1936–1940. The article's main argument is, that due to their photo album aesthetic the propaganda brochures were invoking the intimacy of a family album.
Re-Reading the Photographic Archive: The Propagandistic Staging of the Portuguese Estado Novo in the Braga District
Authors: Ferreira Fatima Moura , Leal Patricia 
Published: November 2018

Re-reading the Photographic Archive: The Propagandistic Staging of the Portuguese Estado Novo in the Braga District The article focuses on visual representations of political propaganda in a local context in the early years of the Estado Novo. Braga, the city of the military coup of 28 May 1926, became nationally famous because of its symbolic value, profusely exploited by the government and the local elites. By means of thick description of iconographic material, this study analyses the use of photography in terms of symbolic materialisation, within the processes of circulation and reception of aesthetic and artistic codes fostered and spread by the «politics of spirit».
ERİTROSİT DAĞILIM HACMİ ACİL SERVİSTE BURUN KANAMASININ CİDDİYETİNİ ÖN GÖREBİLİR Mİ?
Authors: KARAMAN Kivanç , ENHOŞ Şerafettin , OSKAY Alten , ARMAĞAN Hamit Hakan 
Published: November 2018

Amaç:
Bu çalışmada burun kanaması için risk faktörlerinin sıklıkları ortaya konulmaya
çalışılırken aynı zamanda bu risk faktörlerinin acil serviste burun kanaması yönetimi
üzerine etkisi olup olmadığı sorgulandı.Gereç
ve Yöntem: Erişkin acil servisde 01/01/2017-01/01/2018 tarihleri arasında burun
kanaması (R04.0) tanı kodu girilen hastaların dosyaları tarandı ve hastaların
isim, yaş, cinsiyet, başvuru tarihi, tıbbi özgeçmiş, kullandığı ilaç, vital
bulguları, konsultasyon bilgileri ve laboratuar bulguları kaydedildi. Travma
hastaları ve 18 yaş altı hastalar çalışma dışı bırakıldı. Konsultasyon istenen
hastalar ciddi burun kanaması olarak değerlendirildi.Bulgular:
Çalışmaya 68 erkek, 40 kadın olmak üzere toplam 108 hasta dahil edildi.
%70.4 (n:76) hasta 50 yaş üzeri olduğu
en sık başvurunun sırasıyla %30.6 (n:33) ve %29.6 (n:32) ile kış ve ilkbahar
aylarında olduğu görüldü. %46.3 (n:50) hastada hipertansiyon, %31.5 (n:34)
hastada ilaçlara bağlı kanama saptandı. %19.4 (n:21) hastaya konsultasyon
istendiği görüldü. Konsultasyon istenen ve istenmeyen hastaların birbiri ile
karşılaştırılması sonucunda erkek cinsiyet ve yüksek Eritrosit Dağılım Genişliği
(RDW) açısından anlamlı farklılık saptandı (P değerleri sırasıyla 0.016 ve
0.029).

Sonuç: Acil servise başvuran burun kanamalı hastalarda
yüksek RDW ve erkek cinsiyet kanamanın ciddiyetini gösteren parametreler olarak
ortaya çıkmaktadır. Acil serviste burun kanamalı hasta yaklaşımında bu
parametreler de göz önünde bulundurulmalıdır.
Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment
Authors: Vorontsova M. S. , Karmakova T. A. , Plotnikova E. A. , Morozova N. B. , Abakumov M. A. , Yakubovskaya R. I. , Alexeev B. Ya. 
Published: November 2018

Introduction.Approaches based on the principles of a targeted therapy are considered a promising strategy that is capable to improve the effectiveness of treatment for bladder cancer (BC) patients.The purposeof the study was to establish an orthotopic xenograft model of human BC in mice and to prove its suitability for experimental examination of drugs targeting the epidermal growth factor receptor (EGFR).Materials and methods.The objects of the study were ectopic subcutaneous and orthotopic human BC xenografts established using EJ and 5637 human BC cell lines. The growth of orthotopic xenografts in vivo was assessed by magnetic resonance imaging. Tumor tissues were investigated using histological and immunohistochemical techniques.Results.It was shown that EJ and 5637 xenografts exhibit a good reproducibility, a sufficient blood supply of the tumor tissues, a high level of EGFR expression, and different pattern of a subcellular receptor localization. Implantation and subsequent proliferation of human EJ or 5637 cells in the murine bladder mucosa presumably results in muscle-non-invasive tumor formation.Conclusions.The EJ and 5637 xenograft models can be useful for investigation of the efficacy of EGFR-targeted biotherapeutic treatments.
Recombinant human PRAME immunization reducesPRAME-expressing tumor growth in mice
Authors: Finashutina Yu. P. , Lyzhko N. A. , Kasatkina N. N. , Kesaeva L. A. , Tikhonova V. V. , Misyurin V. A. , Baryshnikova M. A. , Misyurin A. V. 
Published: November 2018

Intrоduction.Human antigen PRAME is preferentially expressed in a number of different tumor types and may be a potent target for anti-tumor immunotherapy.Purpose.To study anti-tumor action of immunogenic mix recombinant PRAME protein and adjuvant in mice with innate immunity.Materials and methods.C57BL/6 female mice were used for immunization with purified human recombinant protein PRAME. Human PRAME gene coding sequence was cloned in mammalian expressing vector pCEP4 and resulting plasmid was introduced in mouse melanoma B16F10 cells by transfection followed by RQ-PCR, Western blot and flow-cytometry analysis. Then stably PRAME-transfected melanoma cells were injected in mice.Results.The mouse melanoma B16F10 cells stably expressing human PRAME protein were obtained. We demonstrate the 10-fold decreased tumor volume in mice with melanoma B16F10 expressing human PRAME after preventive immunization series with recombinant PRAME protein. The tumor volume reducing was correlated with high titer (6.14 × 10 5) of anti-PRAME antibodies in mice sera.Conclusion.These data indicate that recombinant protein PRAME is immunogenic and may be a potent antigen for immunotherapuetics studies.
Preclinical trial of Bacteriosens used for the photodynamic therapyof malignant tumors, including prostate cancer
Authors: Morozova N. B. , Plotnikova E. A. , Plyutinskaya A. D. , Stramova V. O. , Vorontsova M. S. , Pankratov A. A. , Yakubovskaya R. I. , Makarova E. A. , Lukyanets E. A. , Kaprin A. D. 
Published: November 2018

Introduction.Bacteriochlorins are the most promising photosensitizers absorbing in the near-infrared spectral region. Their use can enhance the efficiency of photodynamic therapy due to the deeper penetration of radiation into the tumor.Objectiveto conduct a preclinical study of the photoinduced antitumor activity and biodistribution of Bacteriosens.Materials and methods.Bacteriosens is a preparation based on meso-tetra(3-pyridyl)bacteriochlorin absorbing at 747 nm. Photoinduced cytotoxicity was investigated in vitro using human tumor cells: A549, Hep 2, BT-474, MCF-7, SK-BR-3, PC3, and EJ and murine tumor cells: S37, C26, and LLC. In vivo studies were performed in mice with large and small tumors (S37, LLC, and C26).Results.In vitro investigation show that bacteriosens during optical irradiation led to the effective suppression of tumor cell growth in culture (the IC50 value varied from 0,08μМ to 1,21 μМ) and had no toxicity without exposure to light. The effective photodynamic therapy regimen using Bacteriosens in mice with inoculated small and large tumors of different genesis resulted in regression of a primary tumor node on 90–100 % of the animals in the absence of tumor recurrence within 90 days after treatment.Conclusion.Bacteriosens is a promising agent for the photodynamic therapy of small and large tumors; it can be successfully used as an alternative, organ-sparing minimally invasive treatment for malignant tumors, including prostate cancer.
Equitoxicity Cisplatin-RONC® and Cisplatin-Teva at a single injection to mice and rats
Authors: Bukhman V. M. , Ermakova N. P. , Konyaeva O. I. , Kulbachevskaya N. Yu. , Sergeev A. A. , Chaley V. A. 
Published: November 2018

Introduction.The development of high-quality domestic reproduced dosage form of сisplatin is necessary to improve the treatment conditions of cancer patients.Purpose of research.Comparative preclinical study of acute toxicity of newly developed in SIC Oncology reproduced dosage form Cisplatin-RONC® with commercial preparation Cisplatin-Teva.Materials and methods.The standard methods of estimation of acute toxicity of preparations on small laboratory rodents are used.Results.Acute toxicity of the compared forms of cisplatin is not significantly different from the effect on the survival and body weight of experimental animals.Summary.Compared generic and commercial formulations cisplatin almost equitoxic after a single intravenous administration to mice and rats.
Redes sociales y estudiantes: motivos de uso y gratificaciones. Evidencias para el aprendizaje
Authors: García-Ruiz Rosa , Tirado Morueta Ramón , Hernando Gómez Angel 
Published: November 2018

Aunque las nuevas generaciones utilizan las redes sociales como un medio de comunicación habitual, en el ámbito educativo aún no se han utilizado de manera generalizada por los docentes como recurso didáctico. Conocer las gratificaciones que encuentran las nuevas generaciones al usar las redes sociales, permitirá al profesorado hacer un uso estimulante de estos medios en la educación secundaria y universitaria. El objetivo de este trabajo es conocer cuáles son las gratificaciones que encuentran los estudiantes de educación secundaria y universitaria al utilizar intensamente las redes sociales Facebook, Instagram y YouTube. Utilizando la teoría de Usos y Gratificaciones, se recogen datos a través de un cuestionario de estudiantes españoles de educación secundaria (N=260) y universitarios (N=315). Los resultados muestran que los estudiantes de secundaria buscan una mayor presencia social y velan por su propia imagen, mientras que los estudiantes universitarios buscan entretenimiento. Finalmente, se discuten los resultados y las implicaciones para un uso estimulante y didáctico de las redes sociales en contexto de enseñanza-aprendizaje.