bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prototyping sutureless shape memory valve stent via integrated 3D printing
Authors: Yang Meng , Yuan Chao , Chen Xi , Jiang Xiaochun , Wang Tiejun 
Published: November 2024

Abstract
Transcatheter aortic valve replacement (TAVR) has increasingly emerged as a forefront option for treating aortic valve diseases. However, the currently prevalent valve prostheses used in TAVR typically involve stitching biologic leaflets onto metallic stents, which introduces challenges in the durability of leaflets and the biocompatibility of metallic stents. This work proposes an integrated additive manufacturing method for prototyping sutureless prosthetic aortic valves that combine shape memory polymer (SMP) stents and hydrogel valve leaflets. The SMP stent exhibits sufficient toughness to maintain structural integrity upon shape memory programming, while the Fe3+-treated hydrogel leaflets possess sufficient swelling resistance to ensure dimensional stability. Finally, the proof-of-concept valve stent is successfully fabricated by integrated 3D printing and validated via an in vitro hemodynamic experiment. Overall, our approach holds promise for prototyping sutureless polymeric valve stents for future generations.
Electromechanical characteristics analysis of L-shaped pipelines with enhanced active constrained damping treatment
Authors: Zhang Zihan , Li Pengfei , Wang Wenzeng , He Tong , Yu Tao , Gao Peixin 
Published: November 2024

Abstract
Fluid-conveying pipelines are widely employed in various engineering fields, such as aerospace, nuclear, and marine fields. These pipelines work in serious vibration environments, which can quickly damage the pipeline system. The vibration control of pipelines is a prominent challenge in the engineering field. This paper is aimed to investigate the electromechanical analysis characteristics of L-shaped pipelines with the enhanced active constrained layer damping (EACLD) structure. A finite element model of the L-shaped pipeline with EACLD is established. The dynamic behavior of an L-shaped pipeline with an EACLD structure was analyzed in both the time and frequency domains. The influence of the voltage and the position, the length and the elastic modulus, the thickness and the edge element parameters are all considered. Additionally, the influence of the EACLD patch orientation on static displacement and stress are considered. Simulation results indicate that reasonable selection of the parameters for the EACLD patch and edge element can enhance vibration damping effectiveness, which can provide effective design guidance for active vibration control of the pipeline system.
An image too many: the contemporary biopic, the historical body, and the documentary footage trope
Authors: Wilder Seth A 
Published: November 2024

Abstract
This article explores the inclusion of historical footage at the end of biopics. The impact of such footage, commonly appended to recent films, varies depending on the specific film. By drawing on theories of viewership, historical film, ontology, and epistemology, this investigation attempts to shed light on why this footage is sometimes, but not inevitably, troubling. Its analysis of the use of such footage in Bohemian Rhapsody and I’m Not There delves into the viewer’s relationship with images and the complexities arising from the intersection of reality and fiction. By exploring the shifting modes of engagement that influence the viewer’s experience, the analysis suggests that this choice may imply a claim to historical authenticity or truth. In questioning the reasons for the increasing prevalence of this trope in contemporary biopics, this article considers the implications of blurring the boundaries between the real and the imaginary.
Medical Risk, Patient Hope, and Hospital Chaplaincy: Cautionary Tales
Authors: Cherry Mark J 
Published: November 2024

AbstractSecular bioethics fails to grasp the central moral and spiritual realities of medicine. As the authors in this issue of Christian Bioethics argue, contemporary healthcare practice is often based on the false premise that medical science can secure the safety of human life. Yet, the standard “biopsychosocial model” of medicine fails to grasp the theological dimensions of healthcare often harming patients and their families in the process. Indeed, as the articles explore, all too often secular bioethics manipulates medicine to achieve immoral purposes, such as active euthanasia of the sick or elderly. Such spiritual decay is acutely manifested in the pressure put on patients to accept an economically efficient and medically expedient assisted death as well as in how society often treats the human body as mere res—a thing unimportant in itself apart from animation as a living person. Together the articles illustrate that without careful religiously grounded advice modern medicine is often spiritually disorienting for both patients and practitioners.
Risk factors for readmission following esophagectomy and gastrectomy for cancer
Authors: Geerts J F M , van den Berg I , van Nistelrooij A M J , Lagarde S M , Wijnhoven B P L 
Published: November 2024

Abstract

Introduction
Hospital readmission after surgery is a key quality indicator. This nationwide cohort study aimed to assess readmission rates following esophagectomy and gastrectomy for cancer and identify associated risk factors.

Methods
Data were extracted from the Dutch Upper GI Cancer Audit (DUCA) for patients with esophagogastric cancer who underwent esophagectomy or gastrectomy with curative intent between January 2011 and June 2016. Logistic regression analysis identified risk factors for 30-day readmission.

Results
In total, 5566 patients were included. Readmission within 30 days occurred in 483 of 3488 (13.8%) patients after esophagectomy and 243 of 2078 patients (11.7%) after gastrectomy. Both minor (Clavien Dindo 1–2) and major (Clavien Dindo ≥3) postoperative complications were independent predictors of readmission after esophagectomy (OR 2.99; 95%CI 2.23–4.02; p &lt; 0.001 and OR 5.20; 95%CI 3.82–7.09; p &lt; 0.001). Specific complications included pulmonary (OR 1.49; 95%CI 1.20–1.85; p &lt; 0.001), gastrointestinal (OR 2.43; 95%CI 1.94–3.05; p &lt; 0.001), and infectious (OR 2.27; 95%CI 1.60–3.22; p &lt; 0.001). Prolonged length of stay (pLOS) was associated with higher readmission rates in patients without complications following esophagectomy (OR 1.91 95% CI 1.19–3.07; p = 0.008), but lower rates in those with complications (OR 0.65 95% CI 0.51–0.83; p &lt; 0.001). For gastrectomy, postoperative complications were also linked to readmission (OR 3.18; 95%CI 2.30–4.40; p &lt; 0.001), particularly gastrointestinal (OR 2.16; 95%CI 1.40–3.32; p &lt; 0.001), and infectious (OR 3.80; 95%CI 2.53–5.71; p &lt; 0.001).

Conclusion
Readmission after esophagogastric resection is common, particularly among patients with both minor and major postoperative complications. Prolonged stay after esophagectomy impacts readmission risk differently based on the presence of complications.
Carbon capture and recycling technology of carbon resources under the target of carbon neutrality
Authors: Tao William Li Wei 
Published: November 2024

Abstract
Carbon capture and recycling (CCR) offers a promising solution to mitigate CO2 emissions. Unlike traditional carbon capture and storage, CCR uses green hydrogen and natural gas infrastructure to enhance process efficiency, capturing over 90% of CO2. By converting CO2 and hydrogen into methane, the system provides a low-carbon alternative to natural gas. CCR is cost-effective and scalable, with reduced risks of long-term CO2 storage. However, challenges like hydrogen production and economic viability remain, requiring further research. CCR could be key in achieving carbon neutrality and addressing future energy demands.
Knowledge, attitudes, and practices of community pharmacists providing over-the-counter emergency hormonal contraception: a scoping review
Authors: Nona Ruth A , Ray Robin A , Taylor Selina M , Glass Beverley D 
Published: November 2024

Abstract

Objectives
Reducing the rate and impact of unintended pregnancy through effective contraception is a public health goal. Since deregulation, globally, ease of access to community pharmacists has enabled them to play a key role in the provision of emergency hormonal contraceptive pills (ECP). The aim of this scoping review is to explore pharmacists’ overall knowledge of and attitudes and practices towards the provision of emergency contraception.

Methods
A systematic literature search for the period from 1999 to 2023 was conducted using Scopus, Medline (Ovid), CINAHL, Emcare, Web of Science, and Google Scholar. Keywords such as emergency contraception, emergency contraceptive, morning after pill, plan B, pharmacist, community pharmacist, and pharmacy were applied. Articles published only in English that described the knowledge, attitudes, and practices of community pharmacists providing emergency contraception were included in this review.

Key findings
Twenty studies met the inclusion criteria. Despite positive attitudes towards the provision of ECP, there is a clear deficit in both the knowledge and counselling practices of pharmacists, with some pharmacists lacking an open attitude towards the supply of ECP to adolescents and third parties. Usage of a private counselling area ranged from 0% to 90% highlighting privacy for patients seeking ECPs is lacking during consultations. In countries where practice guidelines are available, these are often not being optimally utilized.

Conclusions
This review has highlighted gaps in pharmacists’ knowledge and counselling practices, demonstrating shortcomings in pharmacists’ education, training, and application of professional practice guidelines. Future research on ECP guidelines is recommended to improve implementation and usability in practice.
Capitalist and anti-capitalist placemaking through street art
Authors: Kukla Quill R 
Published: November 2024

ABSTRACT
Street art can function as a tool of placemaking. It shapes how we experience, move through, and attach meaning to space, as well as how space is territorialized and bounded. Street art can be a restructuring force that changes how a space is legible or interpretable to its users, how it is used, how it is experienced, and how it forms a territory with insiders and outsiders. But how street art does this along with what kinds of impact it has varies dramatically from neighborhood to neighborhood. More specifically, the relationship between street art, placemaking, and capitalism is remarkably different in different neighborhoods. Street art can support capitalist placemarketing, or it can work toward secession from the capitalist landscape, either by preserving or by creating alternative place identities. I use three different neighborhoods in New York City—The Bowery, El Barrio, and the South Bronx—as case studies for each of the three phenomena, respectively. I end by examining a paradox that street art faces: explicitly anti-capitalist street art is easily coopted by capitalist forces that seek to commodify its aesthetic, so attempts to use street art to combat capitalist appropriations of space often (though not always) backfire.
Seasonal drought drives sugarcane borer outbreaks
Authors: Wang Leyun , Zhao Zihua 
Published: November 2024

Abstract
Sugarcane borers (SCB) pose a major threat to sugarcane production. Effective pest management requires detailed knowledge of SCB phenology and population dynamics in responses to environmental changes. This study tested the hypothesis that drought drives SCB outbreaks and identified season-specific effects by investigating large-scale field data of these pests in 4 key sugarcane-growing provinces in south subtropical and tropical China (Guangxi, Guangdong, Yunnan, and Hainan) from 1987 to 2018. The standardized precipitation evapotranspiration index was used as a drought indicator at various time scales. We found that drought during a specific month can result in significant changes in the annual SCB outbreak status, such as November in Guangxi, June in Yunnan, and September in Hainan. By summarizing seasonal effects of drought across study locations, we found a general pattern that SCB outbreaks increased with drier conditions in summer, whereas they were promoted by wetter conditions in fall. This research provides crucial knowledge for predicting SCB outbreaks under seasonal and climate changes. This information is also highly critical for increasing the efficiency and accuracy of integrated pest management strategies.
Ascorbic acid and glucose can cause significant interference on quantitative measurement of biochemistry analytes in urine
Authors: Mašković Sara , Nikolac Gabaj Nora 
Published: November 2024

Abstract

Background and aims
Preanalytical errors due to interferences can lead to inaccurate results, necessitating an understanding of potential interferences for each test. This study explores the impact of elevated concentrations of ascorbic acid and glucose on urine analysis, a pivotal diagnostic tool.

Methods
Conducted at the Clinical Institute of Chemistry, KBC Sestre milosrdnice, the research utilized a 24-hour urine sample. Parameters assessed included total proteins, albumin, amylase, sodium, potassium, chlorides, calcium, phosphates, magnesium, creatinine, urea, and uric acid. Various concentrations of added interferents were prepared for duplicate measurements using statistical analysis in Microsoft Excel.

Results
No statistically significant interferences were found in albumin, amylase, sodium, potassium, or phosphate concentrations. However, ascorbic acid interfered with chloride, calcium, and magnesium determinations. Conversely, elevated glucose affected total protein, calcium, magnesium, creatinine, urea, and uric acid determinations. Interference of ascorbic acid with chloride and interference of glucose with total proteins and uric acid displayed a linear relationship.

Conclusions
Results suggest cautious analysis interpretation from certain parameters in patients with elevated glucose and/or ascorbic acid in urine. Whereas ascorbic acid interference may go unnoticed due to its infrequent measurement, routine determination of glucose in urine is crucial, especially for diabetes patients.
Three-year survival follow-up of patients with gastrointestinal cancer treated during the COVID-19 pandemic in Spain: data from the PANDORA-TTD20 study
Authors: García-Alfonso Pilar , Jimenez-Fonseca Paula , Soto-Alsar Javier , Baraibar Iosune , Santos Cristina , La Casta Adelaida , Ghanem Ismael , Pulido Cortijo Gema , Mariño Méndez Axel , Pazo-Cid Roberto , Vera Ruth , Melián Marcos , Alcaide Julia , Graña Begoña , Páez David , Gallego Inmaculada , Lobo Miriam , Borregón Miguel , Fernández Montes Ana , Martínez de Castro Eva , Carmona-Bayonas Alberto , Aranda Enrique 
Published: November 2024

Abstract

Introduction
The initial SARS-CoV-2 pandemic wave in Spain in 2020 precipitated significant paradigm shifts in gastrointestinal oncology patient management. This study captures the “Zeitgeist” of this period by analyzing adaptive strategies, treatment modifications, and survival outcomes, leveraging a 3-year follow-up perspective to extract insights from this unprecedented experience.

Methods
We conducted a multicenter, retrospective cohort study utilizing the RETUD-TTD registry, encompassing 703 patients across 19 Spanish centers in April 2020. We evaluated alterations in clinical practice, therapeutic approaches, coronavirus disease 2019 (COVID-19)-related impacts, and patient survival. A Bayesian hierarchical model was employed to identify potential regional-specific frailties.

Results
The peak of the pandemic in April 2020 catalyzed substantial shifts in oncological care delivery. Outpatient consultations decreased by 13%, with a notable selection bias toward cases with more favorable prognostic indicators. Multidisciplinary tumor board discussions were significantly curtailed (eg, mean monthly colorectal cancer cases discussed was reduced from 40 to 23), compromising qualitative care measures. This occurred concurrently with an average of over 3 oncologists per center on medical leave. Contrary to initial concerns, the healthcare system demonstrated remarkable resilience. The majority of patients received standard-of-care therapies with regulatory approval, albeit with regimen modifications in 15% of cases. These adaptations included extended dosing intervals, dose intensity modulations, and transitions to oral formulations while maintaining unexpectedly stable long-term survival outcomes. The Bayesian frailty model detected minimal unmeasured prognostic factors related to geographic location, and the type of pandemic-induced adaptation did not significantly impact survival. The model revealed that coronavirus disease 2019’s impact was less pronounced than other core prognostic variables.

Conclusions
The decentralized Spanish healthcare system exhibited substantial robustness in managing pre-pandemic diagnosed gastrointestinal malignancies, despite asymmetrical, and occasionally severe organizational disruptions. The insights gleaned from this experience could inform future crisis preparedness strategies and optimize care provision during subsequent public health emergencies.
Real-world application of disitamab vedotin (RC48-ADC) in patients with breast cancer with different HER2 expression levels: efficacy and safety analysis
Authors: Wang Ke , Xu Ting , Wu Jing , Yuan Yuan , Guan Xiaoxiang , Zhu Chengjun 
Published: November 2024

Abstract

Background
Disitamab vedotin (RC48-ADC), an antibody-drug conjugate (ADC), combines specific antibody disitamab with cytotoxicity monomethyl auristatin E to effectively target the human epidermal growth factor receptor 2 (HER2) protein on tumor cells for precise elimination. Recent studies have demonstrated that RC48-ADC offers therapeutic benefits for patients with HER2-positive and HER2-low-expression breast cancer (BC). However, a thorough exploration of its efficacy and safety in real-world settings for patients with metastatic breast cancer (mBC) is currently lacking.

Methods
This retrospective, multicenter, real-world study included patients with mBC who received RC48-ADC from September 2021 to March 2024. These patients include HER2-positive BC and HER2-low-expression BC. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), restricted mean survival time, objective response rate (ORR), and disease control rate (DCR). Factors affecting efficacy and the occurrence of treatment-related adverse events (TRAE) were evaluated.

Results
The study included a cohort of 89 patients with mBC, with 48 of those being identified as HER2-positive. As of March 2024, 22 deaths were recorded, with an immature median OS. Total PFS varied from 1.0 to 31.2 months, with a median of 5.5 months (95% CI, 4.368-6.632). HER2-positive patients exhibited prolonged PFS compared with HER2-low-expression patients (6.6 months vs 4.1 months, P = .023). The overall ORR stood at 25.8% (95% CI, 0.178-0.358), with higher rates observed in HER2-positive patients compared with HER2-low-expression patients (31.3% vs 19.5%). Similarly, the overall DCR was 78.7% (95% CI, 0.691-0.859), with HER2-positive patients demonstrating superior DCR compared with HER2-low-expression patients (83.3% vs 73.2%). Notably, HER2 expression emerged as the primary determinant of RC48-ADC efficacy. The most prevalent TRAE among all patients included leukopenia (21.3%) and alopecia (20.2%).

Conclusion
RC48-ADC showcases promising efficacy and manageable safety in patients with both HER2-positive and HER2-low-expression mBC.
Coping Power at the REACH School Network: A pilot feasibility study
Authors: Rasiah Saisujani , Andrade Brendan F , Cohen-Silver Justine , Suri Anjali , Rasiah Shajitha , Huber Joelene , Freeman Sloane J 
Published: November 2024

Abstract

Objectives
School-based health centres (SBHCs) provide developmental and mental health care to children with socioeconomic disparities. We piloted a validated behavioural intervention called Coping Power (CP) for children with disruptive behaviour through our SBHC program. The objective of this pilot study was to examine the feasibility of CP in the SBHC setting.

Methods
All parent/caregiver and child dyads enrolled in CP from 2018 to 2019 and 2021 to 2022 were invited to participate in the study. Demographic information and behaviour rating scales were collected at baseline. Feasibility metrics included attendance and satisfaction survey responses.

Results
A total of 31 parent/caregiver-child dyads were included. Approximately 40% of families had an annual income of &lt;$49,999. Regarding attendance, 22/31 children/parent/caregiver dyads (70.9%) missed ≤2 sessions. Thirteen parents/caregivers completed the CP satisfaction survey and indicated that they were either ‘somewhat’ (n = 4) or ‘very satisfied’ (n = 9) with the program. Of the 18 children who completed the satisfaction survey, 13 (72.2%) shared that either the ‘sort of’ or ‘for sure’ group helped them cope with their anger better.

Conclusions
This pilot study found that CP delivered within the SBHCs was feasible. Improving access to CP for disadvantaged children may improve mental health outcomes.
Exploring mesenchymal stem cells homing mechanisms and improvement strategies
Authors: Sajjad Umar , Ahmed Muhammad , Iqbal M Zohaib , Riaz Mahrukh , Mustafa Muhammad , Biedermann Thomas , Klar Agnes S 
Published: November 2024

Abstract
Mesenchymal stem cells (MSCs) are multipotent cells with high self-renewal and multilineage differentiation abilities, playing an important role in tissue healing. Recent advancements in stem cell-based technologies have offered new and promising therapeutic options in regenerative medicine. Upon tissue damage, MSCs are immediately mobilized from the bone marrow and move to the injury site via blood circulation. Notably, allogenically transplanted MSCs can also home to the damaged tissue site. Therefore, MSCs hold great therapeutic potential for curing various diseases. However, one major obstacle to this approach is attracting MSCs specifically to the injury site following systemic administration. In this review, we describe the molecular pathways governing the homing mechanism of MSCs and various strategies for improving this process, including targeted stem cell administration, target tissue modification, in vitro priming, cell surface engineering, genetic modifications, and magnetic guidance. These strategies are crucial for directing MSCs precisely to the injury site and, consequently, enhancing their migration and local tissue repair properties. Specifically, our review provides a guide to improving the therapeutic efficacy of clinical applications of MSCs through optimized in vivo administration and homing capacities.