bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy and offspring outcomes after artificial insemination with donor sperm
Authors: Zhang Aiping , Ma Xiaoling , Zhang Lili , Zhang Xuehong , Wang Weihua 
Published: April 2019

Abstract
Artificial insemination with donor sperm (AID) is a widely used procedure, but its success rate in China remains uncharacterized. This study investigated the factors associated with occurrence of clinical pregnancy and live birth and evaluated the birth outcomes in the offspring after AID in Northwest China.
We retrospectively reviewed the results of 1805 AID courses in 1046 couples during 2006–2015. We analyzed whether the number of AID cycles, age of the female patient, and number of sperm with progressive motility were associated with the occurrence of clinical pregnancy and live birth. We also evaluated the birth outcomes in the offspring.
Among the 1805 cycles, 447 (24.8%) resulted in clinical pregnancy and 384 (21.3%) resulted in a live birth. Miscarriage occurred in 57 of the 447 cases of clinical pregnancy (12.8%). The proportion of cycles resulting in a live birth decreased significantly with age (P < .001). The proportion of clinical pregnancies that resulted in miscarriage increased with age (P < .001). Cumulative pregnancy rate (the proportion of patients achieving a clinical pregnancy) increased progressively from 23.0% after 1 cycle to 42.7% after ≥5 cycles. The proportion of cycles resulting in clinical pregnancy did not vary with the total number of sperm with progressive motility administered per cycle. Multivariate logistic regression analysis revealed that superovulation treatment and number of cycles were factors associated with clinical pregnancy, while superovulation treatment, number of cycles, and patient age were factors associated with live birth. Among the 384 live births, only one case (0.3%) of birth defect (hexadactyly) was observed.
In patients undergoing AID, clinical pregnancy is associated with superovulation treatment and number of cycles, and live birth is associated with superovulation treatment, number of cycles, and patient age. The risk of birth defects in the offspring after AID is low.
Variant angina induced by carbon monoxide poisoning
Authors: Song Lisha , Bian Ge , Yang Weimin , Li Hai-Feng 
Published: April 2019

Abstract

Rationale:
Carbon monoxide (CO) poisoning can cause severe damage to the nervous system, and can also cause serious damage to organs, such as the heart, kidneys, and lungs. CO damage to myocardial cells has been previously reported. This can lead to serious complications, such as myocardial infarction.

Patient concerns:
A 47-year-old female patient complained of sudden chest pain for 30 minutes. Before admission, the patient had non-radiating burning chest pain after inhalation of soot.

Diagnosis:
An electrocardiogram showed that myocardial ischemia was progressively aggravated, manifested by progressive ST-segment elevation, and accompanied by T wave inversion and other changes. No obvious coronary stenosis was observed in a coronary angiographic examination. Therefore, the patient was considered to have developed variant angina resulting from CO poisoning-induced coronary artery spasm.

Interventions:
The patient was treated with drugs for improving blood circulation and preventing thrombosis, and underwent hyperbaric oxygen therapy.

Outcomes:
Clinical symptoms relieved after the treatment.

Lessons:
Findings from this case suggest that CO can cause coronary artery spasm and it is one of the predisposing factors of variant angina. For these patients, hyperbaric oxygen therapy can improve blood circulation and prevent formation of thrombus and encephalopathy.
Prognostic significance of nuclear Yes-associated protein 1 in patients with nonsmall cell lung cancer
Authors: Zhu Lingling , Ma Guangzhi , Liu Jiewei , Deng Yunfu , Wu Qiang , Chen Wenjie , Zhou Qinghua 
Published: April 2019

Abstract

Background:
Nuclear Yes-associated protein 1 (YAP1) has often been regarded as an adverse prognostic indicator in various tumors. Recent studies have associated YAP1 with unfavorable prognosis in nonsmall cell lung cancer (NSCLC). However, due to small sample sizes, the prognostic value of nuclear YAP1 in NSCLC patients is not well understood. In the present study, we evaluated the prognostic role of nuclear YAP1 in NSCLC patients via a systematic review and meta-analysis.

Methods:
We searched the PubMed, EMBASE, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Databases for papers investigating the prognostic significance of nuclear YAP1 expression in NSCLC patients. Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were calculated with reference to overall survival (OS) and progression-free survival (PFS) of NSCLC patients to provide synthesized estimates of the effects of nuclear YAP1 expression.

Results:
Among 414 cases, higher nuclear YAP1 expression presented as a predictive factor of poorer OS (HR = 1.52; 95% CI: 1.11–2.08; P = .01; I
2 = 0.0%) and decreased PFS (HR = 2.11; 95% CI: 1.52–2.93; P < .001; I
2 = 44.2%) in NSCLC patients. Subgroup analysis revealed shortened OS (HR = 1.63; 95% CI: 1.14–2.34; P = .007; I
2 = 0.0%) and worse PFS (HR = 2.25; 95% CI: 1.53–3.30; P < .001; I
2 = 0.0%) in patients from Asia with higher nuclear YAP1 expression. Prognosis was also worse in patients with III–IV stage cancer (PFSHR = 2.09; 95% CI: 1.45–3.01; P < .001; I
2 = 58.1%) and in patients treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) (OS HR = 1.59; 95% CI: 1.00–2.51; P = .048; I
2 = 15.5%, and PFS HR = 2.35, 95% CI: 1.62–3.42; P < .001; I
2 = 0.0%).

Conclusion:
High expression of nuclear YAP1 was associated with shorter survival outcome in patients with NSCLC.
The frequency and determinants of blood pressure measurement by a health professional in Germany
Authors: Diederichs Claudia , Neuhauser Hannelore 
Published: April 2019

Abstract
Strong evidence exists for the benefits of screening for hypertension to reduce the risk of cardiovascular disease and death. The aim of this study was to analyze the frequency and determinants of blood pressure (BP) measurement by a health professional in the general population and in individuals without hypertension in Germany.
Data from 17,431 participants 15+ years from the cross-sectional GEDA2014/2015-EHIS survey were used to calculate the percentage of the population who had no BP measurement within the last year and the last 3 years. In multivariate models, the determinants of no BP measurement were analyzed. The frequency of BP measurement was compared between 30 European countries.
In Germany, 27.5% of men and 16.6% of women had no BP measurement by a health professional within the last year and 10.9%, respectively 5.4% not within the last 3 years. In individuals without known hypertension, 34.1% of men and 23.6% of women aged 15 to 19 years had no BP measurement in the last 3 years compared to 5.2% of men and 4.8% of women 70+ years. Independent predictors of not receiving a BP measurement in the last 3 years besides age were male sex, good self-rated health, low health awareness, and no medical consultations but not educational level. Germany has low proportions of no BP measurement compared to other European countries.
Hypertension screening needs improvement in all age groups, especially in the young who have the lowest screening proportions but also in the elderly who have the highest hypertension risk.
Condyloma acuminata on the nipple and coronary sulcus of the penis
Authors: Wu Yan , Song Ge , Li Man , Lun Wenhui 
Published: April 2019

Abstract

Rationale:
Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital and perianal squamous mucosa and skin. CA outside the genitals is not common.

Patient concerns:
A 29-year-old male presented with lesions on the left nipple and coronary sulcus after heterosexual contact.

Diagnoses:
Histopathological examination and HPV detection made a definite diagnosis of CA.

Intervention:
The patient was treated with microwave and topical imiquimod cream.

Outcomes:
After 6 months follow-up, there was no sign of recurrence.

Lessons:
This case shows that we should pay more attention to CA outside the genitals in the process of diagnosis and treatment.
Association between heart rate on admission and in-hospital mortality among general inpatients
Authors: Yamamoto Marumi , Ohta Yoshinori , Sakuma Mio , Takeuchi Jiro , Matsumoto Chisa , Morimoto Takeshi 
Published: April 2019

Abstract
Association between heart rate (HR) and in-hospital mortality in general patients irrespective of underlying diseases were not well scrutinized. We assessed the relationship between HR on admission and in-hospital mortality among general inpatients.
We used data from Japan Adverse Drug Events (JADE) study, a prospective cohort study. One tertiary care hospital in Japan with 13 medical and 12 surgical wards, and an intensive care unit (ICU). Patients (n = 2360) were ≥12 years old and admitted to this hospital within 3 months; and pregnant women were excluded. We assessed the relationship between HR and mortality in five (<60, 60–79, 80–99, 100–119, ≥120 beats per minutes [bpm]) groups. We also compared the five HR groups according to the age (<70 years; ≥70 years) and wards (medical; surgical; ICU).
We enrolled 2360 patients (median age, 71 [interquartile range (IQR) 58–81] years) including 1147, 1068, and 145 patients in the medical and surgical wards, and the ICU, respectively. The median (IQR) HR on admission was 78 (68–91) bpm. Ninety-five patients died during hospitalization. Mortalities in the <60, 60–79, 80–99, 100–119, and ≥120 bpm groups were 2.9% (5/175), 2.7% (28/1047), 3.4% (26/762), 8.2% (24/291), and 14.3% (12/84), respectively (P < .001). The adjusted odds ratios of in-hospital mortality was 3.64 (95% CI 1.88–7.05, P < .001) when HR was ≥100 bpm in the medical ward; and 5.69 (95% CI 1.72–18.82, P = .004) when HR ≥120 bpm in the surgical ward. There was no statistically significant relationship with the ICU.
In conclusion, higher HR should be associated with in-hospital mortality among patients with general diseases. Even with less severe condition or outside ICU, HR should be directed attention to and patients with high HR on admission should be taken additional therapy to reduce the further risk of deterioration.
Impact of full field digital mammography diagnosis for female patients with breast cancer
Authors: Wang Tuan , Shuai Jian-jun , Li Xing , Wen Zhi 
Published: April 2019

Abstract

Background:
Previous clinical studies have reported that full field digital mammography (FFDM) can be used for diagnosis on breast cancer (BC) with promising outcome results. However, no study systematically investigates its diagnostic impact on female patients with BC. Thus, this systematic review will assess the accurate of FFDM diagnosis on BC.

Methods:
In this study, we will perform a comprehensive search strategy in the databases as follows: Cochrane Library, EMBASE, MEDILINE, PSYCINFO, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Information, and Wanfang Data from inception to February 28, 2019. All case-controlled studies exploring the impacts of FFDM diagnosis for patients BC will be fully considered for inclusion in this study. Two authors will independently scan the title and abstracts for relevance, and assess full texts for inclusion. They will also independently extract data and will assess methodological qualify for each included study by using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. RevMan V.5.3 software (London, UK) and Stata V.12.0 software (Texas, USA) will be used to pool the data and to conduct the meta-analysis.

Results:
The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of FFDM will be used to determine the diagnostic accuracy of FFDM for the diagnosis of patients with BC.

Conclusion:
Its findings will provide latest evidence for the diagnostic accuracy of FFDM in female patients with BC.

Systematic review registration:
PROSPERO CRD42019125338.
Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer
Authors: Deng Shi , Ren Zheng Ju , Jin Tao , Yang Bo , Dong Qiang 
Published: April 2019

Abstract

Objective:
Number of studies have been performed to evaluate the relationship between prostate stem cell antigen (PSCA) variation rs2294008 and bladder cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association.

Methods:
Pubmed, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), Wan Fang and Weipu databases were searched before June 30, 2018. The strength of associations was assessed using odds ratios (ORs) and 95% confidence intervals (CIs). All of the statistical analyses were conducted using Review Manager 5.3 and Stata 14.0.

Results:
Ten studies involved 14,021 cases and 26,871 controls. Overall, significant association was observed between the PSCA gene variant rs2294008 polymorphism and bladder cancer (T vs C: OR = 1.16, 95%CI = 1.12−1.20; TT vs CC: OR = 1.32, 95%CI = 1.24−1.41; TT vs CT+CC: OR = 1.15, 95%CI = 1.09−1.22; TT+CT vs CC: OR = 1.27, 95%CI = 1.21−1.34). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (T vs C: OR = 1.23, 95%CI = 1.15−1.31) and Caucasians (T vs C: OR = 1.14, 95%CI = 1.10−1.18). The sensitivity analysis confirmed the reliability and stability of the meta-analysis.

Conclusion:
Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer.
Tension pneumothorax-induced Takotsubo syndrome
Authors: Chen Wei-Siang , Hung Ming-Jui 
Published: April 2019

AbstractRationale:Takotsubo syndrome (TTS) is a form of acute and usually reversible heart failure syndrome. Transient left ventricular dysfunction and electrocardiographic changes could mimic acute coronary syndrome but there are actually no obstructive coronary lesions.Patient concerns:A 76-year-old woman with chronic lung disease developed spontaneous tension pneumothorax with the presentation of severe dyspnea, respiratory failure, left ventricular dysfunction, and anterior wall ST-segment elevation on 12-lead electrocardiogram. Acute coronary syndrome was excluded by normal coronary angiograms.Diagnosis:The patient was diagnosed as tension pneumothorax complicated by TTS.Interventions:The woman underwent tubal thoracostomy for tension pneumothorax-induced obstructive shock. However, the patient further underwent ligation bullectomy for persistent air leakage 2 weeks later.Outcomes:The left ventricular dysfunction recovered 1 week after resolution of tension pneumothorax. Anterior wall ST-segment elevation resolved 25 days after admission.Lessons:Concurrent electrocardiograms and echocardiographic serial evaluations should be performed to provide more comprehensive information when dealing with tension pneumothorax patients.
Platelet and peripheral white blood cell counts at diagnosis predict the response of adult immune thrombocytopenia to recombinant human interleukin-11
Authors: Jin Chenghao , Wang Yulu , Cheng Hongbo , Liu Haiyun , Liu Tingting , Ke Bo , Li Anna , Yang Liu , Zhu Qingxiu , Ding Weirong , Luo Minzhi , Wei Yujing , Kong Chunfang 
Published: April 2019

AbstractThis study evaluated the effectiveness of recombinant human interleukin-11 (rhIL-11) in the treatment of immune thrombocytopenia (ITP) and determined whether clinical and laboratory findings predicted the treatment response.This retrospective, single-center, case–control study included 103 adult patients with ITP treated between July 2010 and April 2014 at Jiangxi Province People's Hospital. About 49 patients in the pred+IL group received prednisone (conventional dose) combined with an rhIL-11 regimen, and 54 patients in the pred alone group received prednisone (conventional dose) alone. Demographic data, initial and follow-up platelet counts, proportions of patients achieving platelet counts ≥30 × 109/L (response) and ≥100 × 109/L (complete response) at different time points, and adverse reactions were compared between groups.Complete response rates were similar between groups overall but higher in the pred+IL group than in the pred alone group for newly diagnosed patients and those with severe ITP (P < .05). Proportions of patients achieving response or complete response at different time points were similar between groups overall but higher in the pred+IL group than in the pred alone group for newly diagnosed patients and those with severe ITP (P < .05). Posttreatment platelet count correlated negatively with platelet count at diagnosis and white blood cell (WBC) count at diagnosis in patients with newly diagnosed ITP (r = −0.337,P = .073 andr = −0.367,P = .050, respectively) or ITP with bleeding-related episodes (r = −0.357,P = .020 andr = −0.434,P = .004, respectively). No immediate or postinfusion severe adverse reactions were observed.rhIL-11 increased CR and improved hemostasis in patients with newly diagnosed or severe ITP. Platelet and WBC counts at diagnosis can predict the response to rhIL-11.
Upregulation of lncRNA SNHG1 is associated with metastasis and poor prognosis in cancers
Authors: Yu Jing , Yan Yunmeng , Hua Chunlan , Ming Liang 
Published: April 2019

Abstract

Background:
Accumulating evidence suggested that the expression level of long noncoding RNA small nucleolar RNA host gene 1 (lncRNA SNHG1) was upregulated in various cancers, and high expression of SNHG1 was associated with metastasis and prognosis in patients with cancer.
The relationship between SNHG1 expression and metastasis or prognosis in malignant tumors was investigated in this meta-analysis.

Methods:
A systematic search was performed in PubMed, Web of Science, and Cochrane Library from inception until May 31, 2018. Hazard ratio (HR) or odds ratio (OR) with 95% confidence intervals (95% CIs) were calculated to demonstrate prognostic value of SNHG1 using Stata 12.0 software.

Results:
A total of 10 studies including 1129 patients were finally enrolled in the meta-analysis based on the inclusion and exclusion criteria. Increased SNHG1 expression was significantly associated with lymph node metastasis (OR = 3.28, 95% CI = 2.02–5.33) and advanced TNM stage (OR = 0.26, 95% CI = 0.16–0.43). Moreover, high expression of SNHG1 could predict poor overall survival (HR = 2.32, 95% CI = 1.90–2.83), event-free survival (HR = 1.58, 95% CI = 1.06–2.35), recurrence-free survival (HR = 2.15, 95% CI = 1.23–3.77), progression-free survival (HR = 2.75, 95% CI = 1.70–4.46), and disease-free survival (HR = 1.93, 95% CI = 1.10–3.40) in patients with cancer.

Conclusion:
The present meta-analysis demonstrated that upregulation of lncRNA SNHG1 might serve as a useful prognostic biomarker in various cancers.
Role of programmed cell death ligand-1 expression on prognostic and overall survival of breast cancer
Authors: Li Shichao , Chen Li , Jiang Jun 
Published: April 2019

Abstract

Background:
Recently, the correlation of immunological checkpoint marker programmed cell death ligand-1 (PD-L1) and the prognosis of various cancers has been a research hotspot. The aim of this study is to examine the prognostic effect of PD-L1 in breast cancer.

Methods:
PubMed, EMBASE, Web of Science, the Cochrane Library database were searched for eligible studies and additional hand-searching were reviewed as an augmentation. Pooled hazard ratios (HR) and 95% confidence interval (CI) for overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS)/recurrence-free survival (RFS), and metastasis-free survival (MFS) were estimated using fixed- or random-effect models.

Results:
Data from 19 studies involving 12,505 patients were collected. Study quality was assessed according to guidelines for assessing quality in prognostic studies. PD-L1 expression was significantly associated with lymph node metastasis (P < .001), high tumor grade (P < .001), negative hormone receptor (P < .001), human epidermal growth factor receptor 2 (HER2) positivity (P < .001), high Ki67 (P < .001), and high tumor-infiltrating lymphocytes (TILs) (P < .001). PD-L1 expression had no significant impact on CSS (pooled HR 0.83, 95% CI = 0.64–1.09, P = .19) or MFS (pooled HR 1.11, 95% CI = 0.62–1.97, P = .72), but significantly correlated with shortened OS (pooled HR 1.52, 95% CI = 1.14–2.03, P = .004) and DFS (pooled HR 1.31, 95% CI = 1.14–1.51, P < .000). Subgroup analysis showed that not PD-L1 RNA expression, but protein expression was associated with shorter survival, in addition, the adverse prognostic effect of PD-L1 expression remained in luminal A, luminal B, and HER2 subtype, not in basal-like or triple-negative subtype.

Conclusions:
An elevated PD-L1 expression significantly correlates with high-risk prognostic indicators and decreased survival in patients with breast cancer.
Role of tranexamic acid in nasal surgery
Authors: Ping Wei-dong , Zhao Qi-ming , Sun Hua-feng , Lu Hai-shan , Li Fei 
Published: April 2019

Abstract

Objective:
Nasal surgeries (such as Functional Endoscopic Sinus Surgery, Rhinoplasty, and Septorhinoplasty) are popular procedures. But perioperative bleeding, eyelid edema, and periorbital ecchymosis remain problems. Tranexamic acid (TXA) is an antifibrinolytic, and it was used to reduce the perioperative bleeding. However, there is no enough evidence judging its safety and efficiency. Therefore, a meta-analysis is conducted by us to evaluate the role of TXA in patients undergoing nasal surgeries.

Method:
A search of the literature was performed until June 2018; the PubMed, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases were searched for related articles using search strategy. Two authors independently assessed the methodological quality of the included studies and extracted data. Surgical information and postoperative outcomes were analyzed. Only randomized controlled trial (RCT) articles were included, and subgroup analysis was established to deal with heterogeneity. RevMan 5.3 software was selected to conduct the meta-analysis.

Result:
Eleven RCTs were included in our meta-analysis. There were significant differences in blood loss (P < .001), surgical field quality (P < .001), edema rating of upper (P < .001) and lower (P < .001) eyelid, ecchymosis rating of upper (P < .001) and lower eyelid (P < .001) when comparing the TXA group to the placebo group. However, the difference in operation time (P = .57) was not significant between the two groups.

Conclusion:
Perioperative TXA could reduce the blood loss and improve the quality of surgery field during nasal surgery, and it was helpful for reducing the edema and ecchymosis after nasal surgeries, but it has little influence in reducing the operation time.