bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats
Authors: Maldonado Octavio , Ramos Angel , Guapillo Mario , Rivera Jose , Palma Icela , Rubio-Gayosso Ivan , Ramirez-Sanchez Israel , Najera Nayelli , Ceballos Guillermo , Mendez-Bolaina Enrique 
Published: May 2019

ABSTRACT
The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.
The Longitudinal Associations of Fitness and Motor Skills with Academic Achievement
Authors: SYVÄOJA HEIDI J. , KANKAANPÄÄ ANNA , JOENSUU LAURA , KALLIO JOUNI , HAKONEN HARTO , HILLMAN CHARLES H. , TAMMELIN TUIJA H. 
Published: May 2019

ABSTRACT

Purpose
This study aimed to examine both independent and dependent longitudinal associations of physical fitness (PF) components with academic achievement.

Methods
A total of 954 fourth to seventh graders (9–15 yr [M
age = 12.5 yr], 52% girls) from nine schools throughout Finland participated in a 2-yr follow-up study. Register-based academic achievement scores (grade point average [GPA]) and PF were assessed in the spring of 2013–2015. Aerobic fitness was measured with a maximal 20-m shuttle run test, muscular fitness with curl-up and push-up tests, and motor skills with a 5-leaps test and a throwing–catching combination test. Structural equation modeling was applied to examine the longitudinal associations adjusting for age, gender, pubertal stage, body fat percentage, learning difficulties, and mother’s education.

Results
The changes in aerobic and muscular fitness were positively associated with the changes in GPA (B = 0.27, 99% confidence interval [CI] = 0.06–0.48; B = 0.36, 99% CI = 0.11–0.63, respectively), whereas the changes in motor skills were not associated with the changes in GPA. Better motor skills in year 2 predicted better GPA a year later (B = 0.06, 99% CI = 0.00–0.11; B = 0.06, 99% CI = 0.01–0.11), whereas aerobic and muscular fitness did not predict GPA. GPA in year 1 predicted both aerobic (B = 0.08, 99% CI = 0.01–0.15) and muscular (B = 0.08, 99% CI = 0.02–0.15) fitness, and motor skills (B = 0.08, 99% CI = 0.02–0.15) a year later.

Conclusion
The changes in both aerobic and muscular fitness were positively associated with the changes in academic achievement during adolescence, whereas the changes in motor skills had only borderline significant association. However, better motor skills, although not systematically, independently predicted better academic achievement 1 yr later, whereas aerobic or muscular fitness did not. Better academic achievement predicted better motor skills, aerobic fitness, and muscular fitness. Developmental changes in adolescence may induce parallel and simultaneous changes in academic achievement and PF.
Estimating Tibial Stress throughout the Duration of a Treadmill Run
Authors: RICE HANNAH , WEIR GILLIAN , TRUDEAU MATTHIEU B. , MEARDON STACEY , DERRICK TIMOTHY , HAMILL JOSEPH 
Published: May 2019

ABSTRACT

Introduction
Stress fractures of the tibia are a problematic injury among runners of all levels. Quantifying tibial stress using a modeling approach provides an alternative to invasive assessments that may be used to detect changes in tibial stress during running. This study aimed to assess the repeatability of a tibial stress model and to use this model to quantify changes in tibial stress that occur throughout the course of a 40-min prolonged treadmill run.

Methods
Synchronized force and kinematic data were collected during prolonged treadmill running from 14 recreational male rearfoot runners on two separate occasions. During each session, participants ran at their preferred speed for two consecutive 20-min runs, separated by a 2-min pause. The tibia was modeled as a hollow ellipse and bending moments and stresses at the distal third of the tibia were estimated using beam theory combined with inverse dynamics and musculoskeletal modeling.

Results
Intraclass correlation coefficients indicated good-to-excellent repeatability for peak stress values between sessions. Peak anterior and posterior stresses increased after 20 min of prolonged treadmill running and were 15% and 12% greater, respectively, after 40 min of running compared with the start of the run.

Conclusion
The hollow elliptical tibial model presented is a repeatable tool that can be utilized to assess within-participant changes in peak tibial stress during running. The increased stresses observed during a prolonged treadmill run may have implications for the development of tibial stress fracture.
Patient-centered benefit-risk analysis of transcatheter aortic valve replacement
Authors: Marsh Kevin , Hawken Natalia , Brookes Ella , Kuehn Carrie , Liden Barry 
Published: May 2019

Background: Aortic stenosis (AS) treatments include surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). Choosing between SAVR and TAVR requires patients to trade-off benefits and risks. The objective of this research was to determine which TAVR and SAVR outcomes patients consider important, collect quantitative data about how patients weigh benefits and risks, and evaluate patients’ preferences for SAVR or TAVR. Methods: Patients were recruited from advocacy organization databases. Patients self-reported as being diagnosed with AS, and as either having received AS treatment or as experiencing AS-related physical activity limitations. An online adapted swing weighting (ASW) method – a pairwise comparison of attributes – was used to elicit attribute tradeoffs from 93 patients. Survey data were used to estimate patients’ weights for AS treatment attributes, which were incorporated into a quantitative benefit-risk analysis (BRA) to evaluate patients’ preferences for TAVR and SAVR. Results: On average, patients put greater value on attributes that favored TAVR than SAVR. Patients’ valuation of the lower mortality rate, reduced procedural invasiveness, and quicker time to return to normal quality of life associated with TAVR, offset their valuation ofthe time over which SAVR has been proven to work. There was substantial heterogeneity in patients’ preferences. This was partly explained by age, with differences in preference observed between patients <60 years to those ≥60 years. A Monte Carlo Simulation found that 75.1% of patients prefer TAVR. Conclusions: Most AS patients are willing to tolerate sizable increases in clinical risk in exchange for the benefits of TAVR, resulting in a large proportion of patients preferring TAVR to SAVR. Further work should be undertaken to characterize the heterogeneity in preferences for AS treatment attributes. Shared decision-making tools based on attributes important to patients can support patients’ selection of the procedure that best meets their needs.
Faktor yang Berhubungan dengan Keberhasilan ASI Eksklusif
Authors: Suliasih Rokhmah Ayu , Puspitasari Dwiyanti , Dwi Pawestri Dhasih Afiat 
Published: May 2019

Latar belakang. Pemberian ASI eksklusif (AE) merupakan intervensi yang efektif untuk mencegah penyakit metabolik dan permasalahan kesehatan anak. Data Survey Demografi dan Kesehatan Indonesia (SDKI) tahun 2012 dan 2016 menunjukkan angka ASI eksklusif di Jawa Timur cenderung turun. Faktor yang memengaruhi pemberian AE meliputi faktor pemudah, pendukung, dan pendorong.Tujuan. Mengetahui hubungan antara faktor pemudah (pengetahuan tentang tanda kecukupan ASI, karakteristik sosiodemografi), pendukung (cara persalinan, Inisiasi menyusu dini, paritas ibu), dan pendorong (tenaga kesehatan, keluarga, dan media) dengan keberhasilan AE.Metode. Penelitian potong lintang analitik melalui pengisian kuesioner oleh ibu yang memiliki anak berusia 6-11 bulan yang datang ke Posyandu atau Puskesmas Simomulyo dan Manukan Kulon, Surabaya pada bulan Maret-April 2018. Data hasil pengisian kuesioner dianalisis statistik menggunakan uji Kai kuadrat dan regresi logistik, dengan confidence interval (CI) 95%.Hasil. Didapatkan proporsi AE 61% dari sejumlah 82 ibu, semua ibu pernah melihat iklan formula, dan alasan terbesar (53,1%) ibu tidak memberikan AE karena khawatir ASI tidak cukup. Usia ibu (p=0,020), pekerjaan (p=0,003), pendidikan terakhir (p=0,030), dan riwayat keberhasilan pemberian AE pada anak yang sebelumnya (p=0,032) berhubungan dengan AE.Kesimpulan. Ibu yang berusia 25-30 tahun, berpendidikan tinggi, memiliki riwayat keberhasilan AE, dan tidak bekerja dapat memengaruhi keberhasilan pemberian AE.
Protein-Losing Enteropathy as the Initial Presentation of Gastrointestinal Kaposi's Sarcoma in Previously Undiagnosed HIV Disease
Authors: Curras-Martin Diana , Campbell Natasha , Copca-Alvarez Albino , Casey Kathleen , Lerner William A. , Hossain Mohammad A. 
Published: May 2019

ABSTRACT
Occult Kaposi's sarcoma (KS) presenting as a protein-losing gastroenteropathy is a rare occurrence. We report the case of a 23-year-old male presenting with leg bilateral swelling and epigastric discomfort. A workup revealed human immunodeficiency virus seropositivity, hypoalbuminemia, and small bowel wall thickening on computed tomography scan. Initially there were no mucosal or cutaneous lesions visible. An upper endoscopy demonstrated subepithelial lesions with a reddish appearance involving the palate, cardia, duodenum, and jejunum, consistent with KS. Gastrointestinal involvement is the most common extracutaneous site of KS and is found in about half of the acquired immune deficiency syndrome (AIDS)-related cases. However, only one out of 5 patients are symptomatic in the absence of skin lesions. Antiretroviral therapy along with anthracycline chemotherapy must be promptly initiated to improve chances of survival.
Comparative evaluation of denosumab efficacy of in patients with rheumatoid arthritis and postmenopausal osteoporosis: results of 1-year study in clinical practice
Authors: Dobrovolskaya O. V. , Kovalenko P. S. , Toroptsova N. V. , Dydykina I. S. , Nikitinskaya O. A. , Nasonov E. L. 
Published: May 2019

Objective: to assess bone mineral density (BMD) changes in rheumatoid arthritis (RA) patients with osteoporosis (OP) and in women with postmenopausal OP during therapy with denosumab (DSB) for 1 yearSubjects and methods. 121 women were included: the main group – 69 patients with RA (mean age – 60±7 years), 34 (49.3%) from them received glucocorticoids (GC). Comparison group comprised 52 women with primary OP (mean age – 62±10 years). Measurement of BMD using dual-energy X-ray absorptiometry (DXA) was performed in the lumbar spine (LI–IV), femoral neck (FN), proximal femur as a whole (PF) and distal forearm (DF). DSB was administered subcutaneously at a dose of 60 mg 1 time in 6 months.Results and discussion. In patients with RA, the average increase of BMD for 12 months of treatment was: in LI–IV – 4.6%, in FN-2.8%, in PF-3.0% and in DF-0.7%, and in the comparison group – 5.2; 2.1; 2.9 and 0.9%, respectively. There were no significant differences of BMD changes between the groups. Efficacy of DSB therapy in RA patients with OP did not depend on RA activity, duration of GC therapy and cumulative dose of GC. Adverse events that did not lead to the withdrawal of the drug were noted in 3% of the study participants. There were no fractures during the observation.Conclusion. The efficacy treatment with DSB for 1 year in RA patients with OP and in women with postmenopausal OP is comparable. The use of GC did not have a negative impact on DSB effect.
ASAS criteria for inflammatory back pain: diagnostic significance in patients with inflammatory bowel disease
Authors: Belousova E. N. , Odintsova A. Kh. , Protopopov M. S. , Abdulganieva D. I. 
Published: May 2019

Damage of peripheral joints and spine is a frequent manifestation of spondyloarthritis associated with inflammatory bowel diseases (IBD). One of the most frequent and typical manifestations of axial spondyloarthritis (axSpA) is inflammatory back pain (IBP), which is determined according to the IBP criteria of the International society for the study of spondyloarthritis (The Assessment of SpondyloArthritis international Society – ASAS) 2009. The diagnosis of axSpA is based on the identification of combination of typical changes in the sacroiliac joints (presence of sacroiliitis according to MRI or radiography) with a characteristic clinical picture. However, the diagnostic significance of these criteria and the possibility of use in patients with IBD and chronic back pain have not been studied.Subjects and methods. The study included 84 patients with IBD and back pain. The mean age of patients was 40.5±11.9 years, the duration of IBD symptoms – 8.11±7.67 years.Results and discussion. In our study, the sensitivity of the ASAS criteria for IBD was 76.9% and specificity – 67.2%, positive predictive value was 0.51, a negative predictive value – 0.87. The likelihood ratio of a positive result is 2.3, the likelihood ratio of a negative result is 0.3.Conclusion. The main diagnostic characteristics of ASAS IBD criteria (2009) for patients with IBD were comparable with those in the population of patients with chronic back pain (sensitivity – 79.6% and specificity – 72.4%).
Spectrometric Determination of Content of Methyl Palmitate in Methyl Esters of Waste Cooking Oils
Authors: Marcinkowski Damian , Czechlowski Mirosław , Grzelak Tomasz 
Published: May 2019

Abstract
The second-generation liquid biofuels are fuels derived from non-food raw materials, i.e. waste cooking oils and animal fats. They are waste raw materials from the agri-food industry, hence their quantity is limited, and their quality depends, inter alia, on the place of their acquisition. Considering the fact that rheological properties of liquid biofuels are closely correlated with the quality of raw materials from which they are obtained, the industrial production of biofuels from waste fats requires development of new analytical methods, allowing for a quick assessment of the quality of the obtained products. The aim of the study was to confirm the possibility of using near infrared spectrometry to assess the content of methyl palmitate in biofuels produced from waste cooking oil. The calibration models were based on 41 absorbance spectra recorded in the range of 400-2170 nm for samples containing from 0 to 5 % of methyl palmitate. The obtained results confirmed that there is a possibility of effective detection of the concentration of this ester in biofuel using the spectrum in the range of 1644-1778 nm. The developed PLS calibration models are characterized by a determination co-efficient (R2) exceeding the value of 0.99.
Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry
Authors: Kurajoh Masafumi , Fukumoto Shinya , Emoto Masanori , Murase Takayo , Nakamura Takashi , Ishihara Takuma , Go Hirofumi , Yamamoto Kouji , Nakatani Shinya , Tsuda Akihiro , Yamada Shinsuke , Morioka Tomoaki , Mori Katsuhito , Imanishi Yasuo , Inaba Masaaki 
Published: May 2019

Abstract

Background
We developed a novel high-sensitive assay for plasma xanthine oxidoreductase (XOR) activity that is not affected by the original serum uric acid level. However, the association of plasma XOR activity with that level has not been fully examined.

Methods
This cross-sectional study included 191 subjects (91 males, 100 females) registered in the MedCity21 health examination registry. Plasma XOR activity was determined using our assay for plasma XOR activity with [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Serum levels of uric acid and adiponectin, and visceral fat area (VFA) obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index.

Results
The median values for uric acid and plasma XOR activity were 333 μmol/L and 26.1 pmol/h/mL, respectively. Multivariable linear regression analysis showed a significant and positive association of serum uric acid level (coefficient: 26.503; 95% confidence interval: 2.06, 50.945; p = 0.035) with plasma XOR activity independent of VFA and HOMA-IR, and also age, gender, alcohol drinking habit, systolic blood pressure, estimated glomerular filtration rate (eGFR), glycated hemoglobin A1c, triglyceride, and adiponectin levels. The “gender*XOR activity” interaction was not significant (p = 0.91), providing no evidence that gender modifies the relationship between plasma XOR activity and serum uric acid level.

Conclusions
Plasma XOR activity was found to be positively associated with serum uric acid level independent of other known confounding factors affecting that level, including gender difference, eGFR, adiponectin level, VFA, and HOMA-IR.
Pre-analytical practices for routine coagulation tests in European laboratories. A collaborative study from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM)
Authors: Kristoffersen Ann Helen , Stavelin Anne V. , Ajzner Eva , Kristensen Gunn B.B. , Sandberg Sverre , Van Blerk Marjan , Kitchen Steve , Kesseler Dagmar , Woods Timothy A.L. , Meijer Piet 
Published: May 2019

Abstract

Background
Correct handling and storage of blood samples for coagulation tests are important to assure correct diagnosis and monitoring. The aim of this study was to assess the pre-analytical practices for routine coagulation testing in European laboratories.

Methods
In 2013–2014, European laboratories were invited to fill in a questionnaire addressing pre-analytical requirements regarding tube fill volume, citrate concentration, sample stability, centrifugation and storage conditions for routine coagulation testing (activated partial thromboplastin time [APTT], prothrombin time in seconds [PT-sec] and as international normalised ratio [PT-INR] and fibrinogen).

Results
A total of 662 laboratories from 28 different countries responded. The recommended 3.2% (105–109 mmol/L) citrate tubes are used by 74% of the laboratories. Tube fill volumes ≥90% were required by 73%–76% of the laboratories, depending upon the coagulation test and tube size. The variation in centrifugation force and duration was large (median 2500 g [10- and 90-percentiles 1500 and 4000] and 10 min [5 and 15], respectively). Large variations were also seen in the accepted storage time for different tests and sample materials, for example, for citrated blood at room temperature the accepted storage time ranged from 0.5–72 h and 0.5–189 h for PT-INR and fibrinogen, respectively. If the storage time or the tube fill requirements are not fulfilled, 72% and 84% of the respondents, respectively, would reject the samples.

Conclusions
There was a large variation in pre-analytical practices for routine coagulation testing in European laboratories, especially for centrifugation conditions and storage time requirements.
Masters (and Mistresses) of Menace
Authors: Saunders Graham 
Published: May 2019

AbstractIn Harold Pinter’s last completed project before his death, a screen adaptation of Anthony Shaffer’s playSleuth(1970), a large publicity poster dominates the study of crime novelist Andrew Wyke, describing him as ‘the master of menace.’ This is also a self-referential joke directed at Pinter’s association with ‘comedies of menace,’ such asA Slight Ache(1957) andThe Birthday Party(1958), that succeeded in creating feelings of unease and discomfort in ways that had not been seen in the theatre before.As a repertory actor before he became a dramatist, Pinter was likely to have encountered the fears and insecurities that theatre can create, and these perhaps return in the sinister environments that we find in his early plays. In turn, the queasiness and growing unease we encounter in Pinter’s drama has been appropriated by other ‘childe Harolds’ including Philip Ridley, Anthony Neilson, Martin Crimp, and Jez Butterworth, whose work follows variations of the Pinteresque. This article looks at some of the ways these dramatists have developed on from Pinter’s template of creating a sense of unease, yet at the same time these dramatists show an awareness of how the nature of fear has radically altered since the turn of the millennium. Signs of this change can also be found in Pinter’s work from the 1980 s: whereas previously fear had been vague in its aetiology, now it came out of the shadows to be named: Pinter’s ‘comedies of menace’ gave way to plays about torture by repressive political regimes inParty Time(1991) and memories of the Holocaust inAshes to Ashes(1997).Since then the depiction of states of fear have forked off on two separate paths: latter day ‘childe Harolds’ such as Philip Ridley continue to promote what he has called ‘theatre as a ghost train,’ a place of disorientation designed to induce fear for its own sake, while a larger contingent that include Simon Stephens, Duncan Macmillan, Mike Bartlett, Martin Crimp, and Mark Ravenhill also make fears manifest: these include terrorism and the ensuing War on Terror, the Anthropocene and climate change and the precarity and repression of neo-liberal economies and the alienation of self-hood through technology.
The Aeneas Argument: Personality and Immortality in Kant’s Third Paralogism
Authors: Dyck Corey W. 
Published: May 2019

Abstract
In this paper, I challenge the assumption that Kant’s Third Paralogism has to do, first and foremost, with the question of personal identity. Beginning with a consideration of the treatments of the soul’s personality in Christian Wolff’s rational psychology, I show that, despite being influenced by Locke’s novel account of personhood and confessing a dissatisfaction with the Scholastic definition of the term, Wolff maintained the agreement between his account of personality and the traditional conception. Moreover, Wolff did not put this concept to a forensic use but considered its primary application to be in the context of the demonstration of the soul’s immortality which, according to him, required that after the death of the body the human soul retained its status personalitatis, understood as its distinct capacity to be conscious of its identity over time. Wolff’s account of the soul’s personality, and the use to which he put it, proved rather influential for metaphysicians like G. F. Meier and Moses Mendelssohn, and Kant’s lectures in the 1770’s also betray this influence. Considering the Third Paralogism in light of this context I claim that, rather than taking up the question of whether the numerical identity of the soul can be inferred from the meagre resources of the I think, what is at issue is the rational psychologist’s account of how we are conscious of our numerical identity in different times. Despite disagreeing with the rational psychologist on this score, Kant nonetheless contends that the way in which we are, in fact, conscious of our numerical identity in all times qualifies us as persons and suffices for that concept’s use in the proof of the soul’s immortality. This reading thus makes sense of Kant’s claim that the soul’s personality, even with its transcendental grounding, is “necessary and sufficient for practical use,” and provides a charitable alternative to the recent allegation of a paralogism of pure practical reason on Kant’s part.