bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervention of Orai1 Influences the Response of Nuocytes From Allergic Rhinitis Mice to IL-33
Authors: Lin Lin , Wei Jinjin , Chen Zheng , Tang Xinyue , Dai Fei , Sun Guangbin 
Published: May 2019

Objective: Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of allergic rhinitis (AR). This study aimed to evaluate the intervention of Orai1 on the response of nuocytes from AR mice to interleukin (IL)-33. Methods: We established a murine model of AR. Nuocytes were obtained from the mouse nasal-associated lymphoid tissue. Then, we assessed expressions of Orai1, Ca2+ mean fluorescence intensity (MFI) in nuocytes, and their cellular response to mouse recombinant (rm) IL-33. After that, we administered rmlentivirus vectors (lenti) that encoded small hairpin RNA (shRNA) against ORAI1 (lenti-ORAI1) into nuocytes cultures and again evaluated Orai1 and Ca2+ MFI in nuocytes and their response to rmIL-33. Finally, we adoptively transferred nuocytes alone or nuocytes transfected by lenti or lenti-ORAI1 to AR models to investigate their roles during allergic inflammation. Results: We showed that Orai1 and Ca2+ MFI were upregulated in AR mice nuocytes. These cells were induced to produce more IL-5 and IL-13 by rmIL-33. However, the intervention of Orai1 by lenti-ORAI1 in nuocytes decreased Orai1 and Ca2+ MFI and reduced productions of aforementioned cytokines even after the administration of rmIL-33. Numbers of sneezing, nasal rubbing, and counts of eosinophils were all enhanced after the adoptive transfer of nuocytes. Concentrations of IL-5, IL-13, and IL-33 in the nasal lavage fluid (NLF) of allergic mice were also increased. However, the adoptive transfer of nuocytes transfected by lenti-ORAI1 decreased aforementioned parameters. Conclusion: These findings show that the intervention of Orai1 in nuocytes influences the response of nuocytes to rmIL-33.
Complete Traumatic Spinal Cord Injury: Current Insights Regarding Timing of Surgery and Level of Injury
Authors: Wengel Paula Valerie ter , De Haan Yvette , Feller Ricardo E. , Oner F. Cumhur , Vandertop William Peter 
Published: May 2019

Study Design: A narrative literature review. Objectives: To review the neurological recovery patterns in traumatic spinal cord injury (tSCI) patients with a complete lack of motor and sensory function below the level of injury (ie, ASIA A [American Spinal Injury Association scale]), as well as the impact of level of injury and timing of surgical intervention. Results: Spontaneous neurological recovery in patients with complete tSCI differs per level of injury: patients with cervical and thoracolumbar tSCI recover ≥1 ASIA grade in 17.3% to 34.0% 1 year after injury, compared with 10.7% to 18.6% in thoracic tSCI. Surgical decompression within 24 hours has a beneficial effect on neurological recovery in patients with complete cervical tSCI, whereas this effect is less clear for thoracic and thoracolumbar tSCI. A 1- or 2-grade improvement in the ASIA scale does not necessarily result in functional recovery. Conclusion: In complete tSCI, the level of injury as well as surgical timing affect neurological recovery. There appears to be a beneficial effect of early surgical decompression in patients with complete cervical tSCI, more so than for thoracic and thoracolumbar tSCI. Frequently, the effect of surgical intervention is evaluated by an improvement in ASIA grade, but it is unclear whether this scale is sensitive enough to evaluate meaningful effectiveness of the intervention and desired outcome for patients with tSCI.
Distribution of High-Volume Ankle Arthroplasty Surgeons in United States Metropolitan Areas: Data from the 2012-15 Medicare Provider Utilization and Payment Release
Authors: Stein Brandon , Somerson Jeremy , Janney Cory , Panchbhavi Vinod 
Published: May 2019

Category: Total Ankle Arthroplasty Introduction/Purpose: Although demand for total ankle arthroplasty (TAA) is increasing, access to high-volume TAA surgeons may vary in different geographic regions. Given that low-volume TAA surgeons have demonstrated higher revision rates compared to higher-volume surgeons, access to these high-volume centers is a matter of patient and public health interest. The recent public release of the Medicare Provider Utilization and Payment Public Use File (MPUP-PUF) now allows for identification of individual providers who perform specific procedures. This study analyzed surgeon prevalence, distribution and factors that correlate with higher or lower high-volume surgeon population in metropolitan areas. Methods: The MPUP-PUF was reviewed for the 2012-2015 calendar years and data were extracted for all physicians who performed a minimum of eleven TAA procedures among traditional Medicare patients. These physicians were grouped into major metropolitan areas (population of one million or more). Average reimbursement, number of high-volume TAA surgeons and number of total procedures were calculated per major metropolitan area. The presence of an American Orthopaedic Foot and Ankle Society (AOFAS) fellowship and mean geographic reimbursement were analyzed for correlation with number of high- volume TAA surgeons. Results: The MPUP-PUF for 2012 to 2015 included 58 unique surgeons who performed a minimum of 11 TAA procedures in any of those calendar years, with a combined total 2,281 Medicare TAA procedures. Of these surgeons, 81% practice within major metropolitan areas with population greater than one million. Distribution among major metropolitan areas is highly unequal and higher numbers of surgeons are present in cities with an AOFAS fellowship. Conclusion: Access to high-volume ankle replacement surgeons among the Medicare population is lacking in multiple major metropolitan areas in the United States due to the uneven distribution of these surgeons. This method of analysis allows for opportunities to target training programs as well as placement of physicians to ensure access to high-volume ankle arthroplasty surgeons.
Asthma progression and mortality: the role of inhaled corticosteroids
Authors: O'Byrne Paul , Fabbri Leonardo M. , Pavord Ian D. , Papi Alberto , Petruzzelli Stefano , Lange Peter 
Published: May 2019

Overall, asthma mortality rates have declined dramatically in the last 30 years, due to improved diagnosis and to better treatment, particularly in the 1990s following the more widespread use of inhaled corticosteroids (ICSs). The impact of ICS on other long-term outcomes, such as lung function decline, is less certain, in part because the factors associated with these outcomes are incompletely understood. The purpose of this review is to evaluate the effect of pharmacological interventions, particularly ICS, on asthma progression and mortality. Furthermore, we review the potential mechanisms of action of pharmacotherapy on asthma progression and mortality, the effects of ICS on long-term changes in lung function, and the role of ICS in various asthma phenotypes.Overall, there is compelling evidence of the value of ICS in improving asthma control, as measured by improved symptoms, pulmonary function and reduced exacerbations. There is, however, less convincing evidence that ICS prevents the decline in pulmonary function that occurs in some, although not all, patients with asthma. Severe exacerbations are associated with a more rapid decline in pulmonary function, and by reducing the risk of severe exacerbations, it is likely that ICS will, at least partially, prevent this decline. Studies using administrative databases also support an important role for ICS in reducing asthma mortality, but the fact that asthma mortality is, fortunately, an uncommon event makes it highly improbable that this will be demonstrated in prospective trials.
National Trends in End-of-Life Care for Veterans With Advanced Cancer in the Veterans Health Administration: 2009 to 2016
Authors: Smith Claire E.P. , Kamal Arif H. , Kluger Monica , Coke Patty , Kelley Michael J. 
Published: May 2019

PURPOSE: It is imperative to provide quality end-of-life (EOL) care for patients with cancer. Although rates of hospice use within the Veterans Health Administration have improved, antineoplastic administration and intensive care unit (ICU) admission at the EOL, indicators of aggressive care, have not clearly declined over recent years. METHODS: We identified 32,665 veterans diagnosed with stage IV lung, colorectal, or pancreatic cancer who died between 2009 and 2016 using a novel EOL Dashboard Tool created from Veterans Administration Cancer Registry data. This EOL tool reports the incidence of antineoplastic drug use in the last 14 days of life, ICU admission in the last 30 days of life, and hospice admission or consult. Change from 2009 to 2016 was assessed using a repeated measures one-way analysis of variance with post hoc test for linear trend of time for individual cancers and two-way analysis of variance for all cancers combined. RESULTS: Antineoplastic use in the last 14 days of life declined from 6.8% in 2009 to 4.4% in 2016 ( P = .03). ICU admission in the last 30 days did not change significantly, from 13.3% in 2009 to 14.7% in 2016. The exception was patients with stage IV lung cancer, in whom ICU admissions increased from 12.9% to 16.2% ( P = .01). Patients using hospice services increased from 32.4% to 52.6% ( P < .01). CONCLUSION: Although antineoplastic administration at the EOL is declining for veterans with stage IV cancer, ICU admissions are unchanged and becoming more common in stage IV lung cancer despite increasing hospice use.
Undesirable Britons: South Asian Migration and the Making of a White Argentina
Authors: Bryce Benjamin 
Published: May 2019

AbstractThis article examines the history of South Asian immigration to Argentina before the First World War. The arrival of a relatively small group of Sikh laborers in 1912, alongside other Japanese and Chinese immigrants in the preceding decade, sparked a huge reaction from Argentine politicians and immigration bureaucrats. They restricted entry, pushed for labor market exclusion, and engaged in diplomatic exchanges with British imperial authorities. In their view, mass migration not only had the power to make a white, European nation but also threatened to undermine that same project. This article argues that the dominant vision of Argentina as a white nation was built on not only transatlantic immigration but also Asian exclusion. Drawing on archival research in Buenos Aires and London, it casts new light on both Argentine nationalism and the language of racial hierarchies mobilized in discussions of immigration.
Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing
Authors: Butt Muhammad , Alyami Sabra , Nageeti Tahani , Saeed Muhammad , AlQuthami Khalid , Bouazzaoui Abdellatif , Athar Mohammad , Abduljaleel Zainularifeen , Al-Allaf Faisal , Taher Mohiuddin 
Published: May 2019

Background: Ependymomas are glial tumors derived from differentiated ependymal cells. In contrast to other types of brain tumors, histological grading is not a good prognostic marker for these tumors. In order to determine genomic changes in an anaplastic ependymoma, we analyzed its mutation patterns by next generation sequencing (NGS). Methods: Tumor DNA was sequenced using an Ion PI v3 chip on Ion Proton instrument and the data were analyzed by Ion Reporter 5.6. Results: NGS analysis identified 19 variants, of which four were previously reported missense variants; c.395G>A in IDH1, c.1173A>G in PIK3CA, c.1416A>T in KDR and c.215C>G in TP53. The frequencies of the three missense mutations (PIK3CA c.1173A>G, KDR c.1416A>T, TP53, c.215C>G) were high, suggesting that these are germline variants, whereas the IDH1 variant frequency was low (4.81%). However, based on its FATHMM score of 0.94, only the IDH1 variant is pathogenic; other variants TP53, PIK3CA and KDR had FATHMM scores of 0.22, 0.56 and 0.07, respectively. Eight synonymous mutations were found in FGFR3, PDGFRA, EGFR, RET, HRAS, FLT3, APC and SMAD4 genes. The mutation in FLT3 p.(Val592Val) was the only novel variant found. Additionally, two known intronic variants in KDR were found and intronic variants were also found in ERBB4 and PIK3CA. A known splice site mutation at an acceptor site in FLT3, a 3’-UTR variant in the CSF1R gene and a 5’_UTR variant in the SMARCB1 gene were also identified. The p-values were below 0.00001 for all variants and the average coverage for all variants was around 2000x. Conclusions: In this grade III ependymoma, one novel synonymous mutation and one deleterious missense mutation is reported. Many of the variants reported here have not been detected in ependymal tumors by NGS analysis previously and we therefore report these variants in brain tissue for the first time.
Sexual health advice for MSM and WSW in general practice
Authors: Kelsey Sally 
Published: May 2019

Men who have sex with men and women who have sex with women need specialised health considerations regarding their sexual health. Sally Kelsey describes what these health needs are and what practice nurses can do to ensure health inequalities are reduced People who identify as lesbian, gay or bisexual (LGB) make up a minority of the population, but carry a large burden of sexually transmitted infections (STIs). Some behaviours among men who have sex with men lead to an increased risk of some STIs and women who have sex with women have specific health needs. While specialist sexual health services are well placed to provide services for these patients, many people choose not to or are not able to access these services. Therefore, primary care has a prime opportunity to offer advice and screening for asymptomatic individuals, and to offer opportunistic advice. Health professionals should be educated in these specific health needs, develop awareness of patient risks and discuss sexual behaviours and risks in an open and non-judgmental way.
A obra de arte musical: uma pergunta para Heidegger
Authors: Drucker Claudia 
Published: May 2019

O pensamento de Heidegger sobre as artes considerou a poesia, em primeiro lugar, e depois as artes plásticas. A música quase não é citada. De obras e compositores afirma‑se que não alcançaram relevância histórica (no sentido fundacional que o pensador dá aos termos). Ao mesmo tempo, o pensamento de Heidegger sobre a obra de arte não poderia deixar de abarcar a música e influenciar abordagens posteriores, mesmo que maneira negativa, desconstruindo certezas sedimentadas. No presente artigo, tento expor a dupla direção que caracteriza as linhas principais do pensamento heideggeriano sobre a música, bem como algumas de suas implicações.
GRYNFELTT HERNIA INITIALLY DIAGNOSED AS LIPOMA: A CASE REPORT
Authors: Machado Raniery Soares Sobreira , Brito Raquel Carlos de , Frutuosos Jairo Fernandes , Sant'Anna André Luís , Magalhães Francisco Anselmo , Machado Vital Maria dos Santos Sobreira , Batista Hermes Melo Teixeira 
Published: May 2019

Abstract: Lumbar hernia is a disease that presents unsual and difficult diagnosis. It is most prevalent in males and the elderly. It is presented the case of a 70-year-old male patient with previous trauma in the lumbar region 30 years ago and since then presented as a tumor in that region. He asked for a medical help and, initially, his case was diagnosed as a lipoma, but then Grynfeltt's hernia was identified and properly repaired. Keywords: Lumbar hernia; Grynfeltt hernia; superior lumbar hernia
Of Horses and Jockeys: Perceptions by Academic Entrepreneurs
Authors: Blair Carrie A. , Shaver Kelly G. 
Published: May 2019

AbstractAlthough there has been increasing recent interest in universities as ecosystems for the encouragement of academic entrepreneurship, almost none of that work has dealt with the specific personal motives that might lead academic scientists to start companies. Metaphorically, there has been a substantial body of work describing how to create a better racetrack, some study of what sort of horses best perform in the track, but essentially no examination of the jockeys. We address this gap in the literature in two ways – first by “importing” a variety of psychological characteristics that have been shown to be predictive in the larger entrepreneurship literature, and second by developing a series of context-specific motives. Our study of 50 biomedical scientists in an academic medical center showed, unsurprisingly, that patents matter. More importantly, although the results for the imported psychological characteristics were disappointing, the findings for context-specific motives suggest that founders are distinguished from non-founders primarily by their interest in doing something positive for humanity.
Patrimônio Cultural da Saúde: uma década de reflexão e atuação sobre o campo
Authors: Sanglard Gisele , Costa Renato Da Gama-Rosa 
Published: May 2019

Este artigo se propõe a fazer um balanço dos dez anos em que o patrimônio cultural da saúde se estabeleceu como tema de pesquisa em diversas instituições de ensino e pesquisa no Brasil. Para tal, será dividido em três partes: a primeira, reflete sobre a transformação da área do patrimônio no país; a segunda, pretende fazer um breve balanço historiográfico acerca dos estudos sobre o patrimônio cultural da saúde no Brasil; e a terceira e última parte, procurará analisar o papel dos cursos de pós-graduação e os caminhos que teses e dissertações estão apontando para a temática. Longe de pretender ser um estudo exaustivo, este artigo pretende apresentar uma breve reflexão sobre o tema.
Arqueólogos (s)em fronteiras: o Projecto ANA-lise e o estudo do povoamento do Baixo Guadiana (Portugal e Espanha)entre os séculos VIII a.C. e I d.C.
Authors: Albuquerque Pedro , García Fernández Francisco José 
Published: May 2019

O estudo das fronteiras e dos territórios fronteiriços é um tema de investigação com repercussões evidentes no mundo actual, bem como uma oportunidade para desenvolver estratégias de turismo cultural e protecção do património cultural. Apresentam-se, neste trabalho, algumas questões sobre um projecto de investigação transfronteiriço (ANA-lise/ ANA-lisis) que estuda o povoamento humano ao longo da bacia do Guadiana entre os séculos VIII a.C. e I d.C., bem como o papel do projecto no contexto de outras iniciativas na União Europeia. Apresentam-se, igualmente, alguns resultados preliminares de duas campanhas de prospecção que contribuíram para a elaboração de um tentame de síntese dos processos prévios à construção da fronteira política entre os países ibéricos com o Tratado de Alcañices (1297) e para uma reflexão sobre a necessidade de desenvolver estudos e estratégias de protecção e difusão do património cultural transfronteiriço.
Patrimônio Cultural da Saúde: a preservação do Hospital Frei Antônio (1976-1985)
Authors: Bastos Tarcísio Pereira 
Published: May 2019

O presente trabalho é resultado de uma dissertação de mestrado em que se analisou a trajetória de tombamento do Hospital Frei Antônio, antigo Hospital dos Lázaros do Rio de Janeiro, localizado no bairro de São Cristóvão, e sua relação com as políticas de preservação cultural desenvolvidas pela Prefeitura da Cidade do Rio de Janeiro entre 1975 e 1985. A partir da análise do processo de tombamento, pretendeu-se entender a importância histórica da assistência oferecida aos leprosos no Lazareto de São Cristóvão, que justificou o ato de salvaguarda da edificação como patrimônio cultural carioca na década de 1980. Pretendeu-se, igualmente, assinalar os resquícios materiais da saúde ainda existentes no local. Almeja-se colaborar para os estudos no âmbito da arquitetura hospitalar, história da saúde, história do Rio de Janeiro, patrimônio cultural da saúde, políticas culturais e profilaxia da lepra.
Clinico-pathologic and dynamic prognostic factors in sporadic and familial medullary thyroid carcinoma: an Israeli multi-center study
Authors: Twito Orit , Grozinsky-Glasberg Simona , Levy Sigal , Bachar Gideon , Gross David J , Benbassat Carlos , Rozental Alon , Hirsch Dania 
Published: May 2019

ObjectiveMultiple clinical, pathological and biochemical variables, including the response to initial treatment, are associated with medullary thyroid carcinoma (MTC) prognosis. Studies that include separate analyses of familial and sporadic MTC patients followed for long period are scarce. This study evaluated the association between baseline clinico-pathologic variables and response to initial treatment and short- and long-term disease outcomes in sporadic and familial MTC.MethodsPatients treated for MTC at four tertiary medical centers were retrospectively analyzed. Clinical and pathological data were collected. The outcomes measured included disease persistence 1 year after diagnosis, disease persistence at last follow-up, disease-related mortality (DRM) and all-cause mortality.ResultsThe study enrolled 193 patients (mean age: 48.9 ± 18.7, 44.7% males), of whom 18.1% were familial cases. The mean follow-up period was 10.1 ± 9.4 years (8.5 ± 8.1 in sporadic and 16.9 ± 11.6 in familial MTC). Disease persistence 1-year after diagnosis and at last follow-up was detected in 56.1 and 60.4% patients, respectively. All-cause and DRM were 28.5 and 12.6%, respectively. Extra-thyroidal extension (ETE) and distant metastases (DM) were associated with disease persistence at last follow-up. ETE and DM were also significantly associated with DRM. Complete remission 1 year after diagnosis had high correlation with no evidence of disease at last follow-up (Cramer’s V measure of association 0.884,P < 0.001) and with 100% disease-specific survival (Cramer’s V measure of association 0.38,P < 0.001).ConclusionsApart from clinico-pathologic parameters, close correlation was found between 1-year status and long-term prognosis. These results underscore the importance of combining classical and dynamic factors for both sporadic and familial MTC prognostication and treatment decision making.
Descifrando el clima espacial: ciclos solares y ondas magnéticas de Rossby
Authors: Márquez-Artavia Xiomara 
Published: May 2019

El objetivo de esta investigación es explorar si existe una relación entre las ondas magnéticas de Rossby rápidas o lentas y ciertas observaciones de la actividad solar de largo y muy largo plazo (meses, años, décadas…). El artículo intenta mostrar si los periodos de esas ondas y sus características corresponden a los valores de duración los ciclos de Rieger, Haly, o bien cuasiperiodos de llamaradas y eyecciones de masa coronal. Se inicia con una revisión bibliográfica y un resumen de los resultados de una tesis doctoral que resuelve completamente el modelo matemático en cuestión, con las ecuaciones derivadas de ese trabajo previo, se calcula los periodos de las ondas que serán comparados con las observaciones. Estos resultados teóricos sugieren que cierta actividad solar podría deberse a las ondas magnéticas de Rossby, originadas en el interior del Sol, específicamente en la tacoclina. Las ondas lentas se proponen ligadas a las periodicidades de largo y muy largo plazo y las ondas rápidas de Rossby se asocian con periodicidades de unos años a meses. El estudio de estas perturbaciones de Rossby y sus propiedades, sin duda, va a ayudar a comprender el origen y las características del campo magnético del Sol.