bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Edukasi Pendekatan Spiritual Berbasis Video terhadap Kepatuhan Pembatasan Cairan Klien ESRD yang Menjalani Hemodialisa
Authors: Wijaya Andri Kusuma , Busjra Busjra , Azzam Rohman 
Published: June 2018

The purpose of this research to know effect of health education with spiritual approach based video toward adherence fluid restriction or interdialysis weight gain of patients undergoing hemodialysis. This is a pre experimental onegroup pretest post test. Using total sampling method 22 patients. The mean of samples interdialysis weight gain total score after education was significantly decrease than before education p value 0.011. While proved there was significantly between the adherence fluid restriction patients undergoing hemodialysis will be increas after health education spiritual approach with video based controlled by family support p value 0, 047 while proved was no significantly between the ages of p value 0.364, education level alue 0.949 to interdialysis weight gain of patients undergoing hemodialysis. Health education with spiritual approach to improve adherence fluid restriction in patients undergoing hemodialysis, which is expected to implemented in order clinic especially patients who undergoing hemodialysis therapy who experienced non-compliance restrictions fluid.
Keywords : Spiritual Based Video, End Stage Renal Disease
Optimasi Multirespon Proses Wire-EDM Menggunakan Metode Taguchi Logika Fuzzy
Authors: R Pathya 
Published: June 2018

Abstrak Penelitian ini membahas optimasi proses pemesinan wire-EDM multirespon karakteristik menggunakan metode Taguchi dan logika fuzzy. Multirespon yang digunakan pada penelitian ini adalah recast layer dan surface roughness dimana masing-masing mempunyai karakteristik kualitas semakin kecil semakin baik. Pada percobaan ini dilakukan dengan memvariasikan enam parameter proses, yaitu on time, open voltage, off time, servo voltage, wire feed, dan water flow. Karena setiap parameter proses tersebut memiliki tiga level, maka rancangan percobaan yang digunakan adalah matriks orthogonal array L27. Untuk mengoptimasi kedua karakteristik dari kedua respon digunakan logika fuzzy. Hasil penelitian menunjukkan bahwa karakteristik dari kedua respon tersebut mengalami peningkatan secara efektif dengan metode ini. Parameter proses pemesinan yang secaara signifikan mempengaruhi recast layer dan surface roughness adalah on time, open voltage dan wire feed.Kata kunci: wire-EDM, Taguchi, logika fuzzy, recast layer, surface roughness
Analisa Bentuk Penampang Batang Engkol Menggunakan Metode Elemen Hingga
Authors: Rasyid Mohammad Kurniadi 
Published: June 2018

Penelitian ini memfokuskan pada disain batang engkol (connecting rod) yang digunakan pada mesin kendaraan baik roda dua mapun roda empat. Latar belakang masalah adalah karena banyak batang engkolyang mengalami kerusakan setelah beberapa waktu penggunaannya. Tujuan dari makalah ini adalah untuk mencari bentuk batang engkolyang lebih tahan terhadap beban yang terjadi selama proses pembakaran dalam ruang bakar mesin. Tiga konsep disain dibuat dan pemilihan konsep terbaik dianalisa menggunakan simulasi numerik. Computer Aided Design (CAD) perangkat lunak digunakan dalam merancang model ini. Kemudian model CAD dianalisis melalui perangkat lunak rekayasa Solidwork. Analisis elemen hingga dilakukan oleh perangkat lunak ini. Analisis dilakukan pada dua jenis bahan yang dipakai, yaitu aluminium dan baja tempa. Beban yang sama diaplikasikan pada ketiga model. Lendutan dan tegangan yang terjadi kemudian di evaluasi. Hasilnya menunjukkan bahwa model nomor satu dengaan pengurangan material di bagian tengah penampang adalah model terbaik bila digunakan sebagai batang engkol. Bahan baja tempa lebih tahan terhadap beban yang terjadi pada batang engkol dibanding alumunium.
S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies
Authors: Leinonen Ville , Rauramaa Tuomas , Johansson Jarkko , Bottelbergs Astrid , Tesseur Ina , van der Ark Peter , Pemberton Darrel , Koivisto Anne M. , Jääskeläinen Juha E. , Hiltunen Mikko , Herukka Sanna-Kaisa , Blennow Kaj , Zetterberg Henrik , Jokinen Pekka , Rokka Johanna , Helin Semi , Haaparanta-Solin Merja , Solin Olof , Okamura Nobuyuki , Kolb Hartmuth C. , Rinne Juha O. 
Published: June 2018

Background: Detection of pathological tau aggregates could facilitate clinical diagnosis of Alzheimer’s disease (AD) and monitor drug effects in clinical trials. S-[18F]THK-5117 could be a potential tracer to detect pathological tau deposits in brain. However, no previous study have correlated S-[18F]THK-5117 uptake in PET with brain biopsy verified tau pathology in vivo. Objective: Here we aim to evaluate the association between cerebrospinal fluid (CSF) AD biomarkers, S-[18F]THK-5117, and [11C]PIB PET against tau and amyloid lesions in brain biopsy. Methods: Fourteen patients with idiopathic normal pressure hydrocephalus (iNPH) with previous shunt surgery including right frontal cortical brain biopsy and CSF Aβ1 - 42, total tau, and P-tau181 measures, underwent brain MRI, [11C]PIB PET, and S-[18F]THK-5117 PET imaging. Results: Seven patients had amyloid-β (Aβ, 4G8) plaques, two both Aβ and phosphorylated tau (P τ, AT8) and one only P τ in biopsy. As expected, increased brain biopsy Aβ was well associated with higher [11C]PIB uptake in PET. However, S-[18F]THK-5117 uptake did not show any statistically significant correlation with either brain biopsy P τ or CSF P-tau181 or total tau. Conclusions: S-[18F]THK-5117 lacked clear association with neuropathologically verified tau pathology in brain biopsy probably, at least partially, due to off-target binding. Further studies with larger samples of patients with different tau tracers are urgently needed. The detection of simultaneous Aβ and tau pathology in iNPH is important since that may indicate poorer and especially shorter response for CSF shunt surgery compared with no pathology.
Effectiveness, Complications, and Costs of Rheumatoid Arthritis Treatment with Biologics in Alberta: Experience of Indigenous and Non-indigenous Patients
Authors: Barnabe Cheryl , Zheng Yufei , Ohinmaa Arto , Crane Louise , White Tyler , Hemmelgarn Brenda , Kaplan Gilaad G. , Martin Liam , Maksymowych Walter P. 
Published: June 2018

Objective.To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous and non-indigenous Albertans with rheumatoid arthritis (RA) participating in the Alberta Biologics Pharmacosurveillance program.Methods.Patients initiating biologic therapy in Alberta (2004–2012) were characterized for disease severity and treatment response. Provincial hospitalization separations, physician claims, outpatient department data, and emergency department data were used to estimate treatment complication event rates and healthcare costs.Results.Indigenous patients (n = 90) presented with higher disease activity [mean 28-joint count Disease Activity Score (DAS28) 6.11] than non-indigenous patients (n = 1400, mean DAS28 5.19, p < 0.0001). Improvements in DAS28, function, swollen joint count, CRP, and patient and physician global evaluation scores were comparable to non-indigenous patients, but indigenous patients did not have a significant improvement in erythrocyte sedimentation rate (−0.31 per month, 95% CI −0.79 to 0.16, p = 0.199). At the end of study followup, 13% (12/90) of indigenous and 33% (455/1400) of non-indigenous patients were in DAS28 remission (p < 0.001). Indigenous patients had a 40% increased risk of all-cause hospitalization [adjusted incidence rate ratio (IRR) 1.4, 95% CI 1.1–1.8, p = 0.01] and a 4-fold increase in serious infection rate (adjusted IRR 4.0, 95% CI 2.3–7.0, p < 0.001). Non-indigenous patients incurred higher costs for RA-related hospitalizations (difference $896, 95% CI 520–1273, p < 0.001), and outpatient department visits (difference $128, 95% CI 2–255, p = 0.047).Conclusion.We identified disparities in treatment outcomes, safety profiles, and patient-experienced effects of RA for the indigenous population in Alberta. These disparities are critical to address to facilitate and achieve desired RA outcomes from individual and population perspectives.
Low-cost diagnostic test for susceptible and drug-resistant tuberculosis in rural Malawi
Authors: Zhang Annie , Jumbe Enoch , Krysiak Robert , Sidiki Sabeen , Kelley Holden V. , Chemey Elly K. , Kamba Chancy , Mwapasa Victor , García Juan I. , Norris Alison , Pan Xueliang J. , Evans Carlton , Wang Shu-Hua , Kwiek Jesse J. , Torrelles Jordi B. 
Published: June 2018

Background: Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most common and often only tuberculosis diagnosis test performed in rural settings, it is labour intensive, has less-than-ideal sensitivity, and cannot assess tuberculosis drug susceptibility patterns. Objective: The objective of this study was to determine the feasibility of a multidrug-resistant (MDR) or extensively drug-resistant (XDR)-tuberculosis coloured agar-based culture test (tuberculosis CX-test), which can detect Mycobacterium tuberculosis growth and evaluate for drug susceptibility to isoniazid, rifampicin and a fluoroquinolone (i.e. ciprofloxacin) in approximately 14 days. Method: In this study, 101 participants were enrolled who presented to a rural health clinic in central Malawi. They were suspected of having active pulmonary tuberculosis. Participants provided demographic and clinical data and submitted sputum samples for tuberculosis testing using the AFB smear and tuberculosis CX-test. Results: The results showed a high level of concordance between the AFB smear (12 positive) and tuberculosis CX-test (13 positive); only one sample presented discordant results, with the molecular GeneXpert MTB/RIF® test confirming the tuberculosis CX-test results. The average time to a positive tuberculosis CX-test was 10 days. Of the positive samples, the tuberculosis CX-test detected no cases of drug resistance, which was later confirmed by the GeneXpert MTB/RIF®. Conclusion: These findings demonstrate that the tuberculosis CX-test could be a reliable low-cost diagnostic method for active pulmonary tuberculosis in high tuberculosis burden rural areas.
Barriers to evidence-based physiotherapy practice for stroke survivors in Ghana
Authors: Quartey Jonathan , Kwakye Samuel 
Published: June 2018

Background: Physiotherapy has evolved over the years, and this has led to an increasing demand in using evidence as a basis for making clinical decisions because evidence-based interventions for stroke have been shown to be effective. However, the inability to carry out any of the evidence-based practice (EBP) processes may constitute a barrier to its application in practice.Aim: To determine the barriers to EBP of physiotherapy services for stroke survivors in Ghana.Methods: A cross-sectional study that involved 121 physiotherapists of the Ghana Physiotherapy Association providing services to stroke survivors. Physiotherapists completed a self-administered questionnaire. Logistic regressions were used to examine relationships between socio-demographic and practice characteristics of respondents and each practitioner factor. A logistic regression was used to identify the association between organisational characteristics and each organisational factor that facilitates EBP.Results: Self-efficacy ratings for performing EBP were below 50% for critical appraisal of the literature and interpretation of statistics. All the participants stated that they had organisational challenges, which tend to affect the implementation of evidence-based physiotherapy practice for stroke. The five most reported barriers to updating knowledge on EBP included lack of organisational mandate (56.2%), insufficient time (46.3%), lack of information resources (43%), lack of understanding of statistics (35.5%) and lack of interest (33.1%).Conclusion: Lack of adequate resources, lack of organisational support and low self-efficacy to perform EBP activities constitute barriers to implementing EBP for stroke survivors.Clinical implications: Findings of the study reinforce the need to develop a supportive organisational infrastructure to increase research integration in physiotherapy practice.
The impact of QTL allele frequency distribution on the accuracy of genomic prediction
Authors: Davoudi Pourya , Abdollahi-Arpanahi Rostam , Nejati-Javaremi Ardeshir 
Published: June 2018

Abstract. The accuracy of genomic prediction of quantitative traits based on single nucleotide polymorphism (SNP) markers depends among other factors on the allele frequency distribution of quantitative trait loci (QTL). Therefore, the aim of this study was to investigate different QTL allele frequency distributions and their effect on the accuracy of genomic estimated breeding values (GEBVs) using best linear unbiased genomic prediction (GBLUP) in simulated data. A population of 1000 individuals composed of 500 males and 500 females as well as a genome of 1000 cM consisting of 10 chromosomes and with a mutation rate of 2.5 × 10−5 per locus was simulated. QTL frequencies were derived from five distributions of allele frequency including constant, uniform, U-shaped, L-shaped and minor allele frequency (MAF) less than 0.01 (lowMAF). QTL effects were generated from a standard normal distribution. The number of QTL was assumed to be 500, and the simulation was done in 10 replications. The genomic prediction accuracy in the first-validation generation in constant, and the uniform allele frequency distribution was 0.59 and 0.57, respectively. Results showed that the highest accuracy of GEBVs was obtained with constant and uniform distributions followed by L-shaped, U-shaped and lowMAF QTL allele frequency distribution. The regression of true breeding values on predicted breeding values in the first-validation generation was 0.94, 0.92, 0.88, 0.85 and 0.75 for constant, uniform, L-shaped, U-shaped and lowMAF distributions, respectively. Depite different values of regression coefficients, in all scenarios GEBVs are biased downward. Overall, results showed that when QTL had a lower MAF relative to SNP markers, a low linkage disequilibrium (LD) was observed, which had a negative effect on the accuracy of GEBVs. Hence, the effect of the QTL allele frequency distribution on prediction accuracy can be alleviated through using a genomic relationship weighted by MAF or an LD-adjusted relationship matrix.
Assessing the impact of the Kuroshio Current on vertical cloud structure using CloudSat data
Authors: Yamauchi Akira , Kawamoto Kazuaki , Manda Atsuyoshi , Li Jiming 
Published: June 2018

Abstract. This study analyzed CloudSat satellite data to determine how the warm ocean Kuroshio Current affects the vertical
structure of clouds. Rainfall intensity around the middle troposphere (6 km in height) over the Kuroshio was
greater than that over surrounding areas. The drizzle clouds over the Kuroshio have a higher frequency of occurrence of
geometrically thin (0.5–3 km) clouds and thicker (7–10 km) clouds compared to those around the
Kuroshio. Moreover, the frequency of occurrence of precipitating clouds with a geometric thickness of 7 to 10 km
increased over the Kuroshio. Stronger updrafts over the Kuroshio maintain large droplets higher in the upper part of the
cloud layer, and the maximum radar reflectivity within a cloud layer in non-precipitating and drizzle clouds over the
Kuroshio is higher than that around the Kuroshio.
Pharmacists’ and patients’ views and feedback on Italian Medicines Use Review (I-MUR)
Authors: Manfrin Andrea , Krska Janet 
Published: June 2018

Rationale, aims and objectives: Although medicine review services are offered by community pharmacists in many countries, they are non-existent in Italy. A novel intervention, I-MUR, was developed for patients with asthma aiming to improve medicines use. The aim of this study was to obtain pharmacists’ and patients’ views on the acceptability of the I-MUR service provided by community pharmacists to asthma patients in 4 Italian regions. Methods: Pharmacists’ expectations, experiences and attitudes to delivering the I-MUR were obtained through questionnaires distributed before and after delivering the I-MUR, plus focus groups. Patients’ views were obtained via questionnaires, distributed by the pharmacists and returned anonymously.Results: Seventy-four pharmacists provided the I-MUR service to 895 asthma patients; 49 pharmacists completed both questionnaires, 53 participated in focus groups and 246 patients returned questionnaires. Barriers anticipated most frequently by pharmacists before the I-MUR were lack of time (53%) and lack of co-ordination with other health professionals (61%), while lack of financial compensation was identified by 37%. Lack of co-ordination proved the most common actual barrier (88%), with lack of financial compensation being cited less frequently after providing the intervention (8%). Ninety-six percent of pharmacists anticipated providing both education on inhaler technique and medication counselling, but in practice slightly fewer had provided these (90% and 86% respectively). Focus groups highlighted a lack of relevant undergraduate education to support medication review and structural barriers within some pharmacies, but described positive patient feedback and a desire to extend the I-MUR. Patient respondents were positive; 62% indicated the reason for having an I-MUR as making sure that they were using medication correctly, 75% considered they benefited from it and 86% would recommend it to others.Conclusions: The I-MUR service was perceived positively by both pharmacists and patients, supporting the extension of medicine review services to community pharmacists in Italy in an enhancement of the person-centeredness of care.
Newbery Medal Novels: What They Reveal about Class Differences and the American Dream
Authors: Lathey Jonathan 
Published: June 2018

Robert Putnam observed that social class differences, now more than ever, determine the life outcomes of American children. Putnam reported evidence that the American Dream is in crisis for children born into lower-class families—these children have far fewer opportunities for success. This might suggest a loss of a survival narrative for these children.
Recent Advances in Materials, Devices, and Systems for Neural Interfaces
Authors: Won Sang Min , Song Enming , Zhao Jianing , Li Jinghua , Rivnay Jonathan , Rogers John A. 
Published: June 2018

AbstractTechnologies capable of establishing intimate, long‐lived optical/electrical interfaces to neural systems will play critical roles in neuroscience research and in the development of nonpharmacological treatments for neurological disorders. The development of high‐density interfaces to 3D populations of neurons across entire tissue systems in living animals, including human subjects, represents a grand challenge for the field, where advanced biocompatible materials and engineered structures for electrodes and light emitters will be essential. This review summarizes recent progress in these directions, with an emphasis on the most promising demonstrated concepts, materials, devices, and systems. The article begins with an overview of electrode materials with enhanced electrical and/or mechanical performance, in forms ranging from planar films, to micro/nanostructured surfaces, to 3D porous frameworks and soft composites. Subsequent sections highlight integration with active materials and components for multiplexed addressing, local amplification, wireless data transmission, and power harvesting, with multimodal operation in soft, shape‐conformal systems. These advances establish the foundations for scalable architectures in optical/electrical neural interfaces of the future, where a blurring of the lines between biotic and abiotic systems will catalyze profound progress in neuroscience research and in human health/well‐being.
Extremely Flexible Indium‐Gallium‐Zinc Oxide (IGZO) Based Electronic Devices Placed on an Ultrathin Poly(Methyl Methacrylate) (PMMA) Substrate
Authors: Kumaresan Yogeenth , Lee Ryeri , Lim Namsoo , Pak Yusin , Kim Hyeonghun , Kim Woochul , Jung Gun‐Young 
Published: June 2018

AbstractThe flexibility of metal oxide‐based electronic devices is severely limited by the thickness of their substrate. To enhance the flexibility of semiconducting metal oxide‐based electronic devices, a new and simple way to fabricate indium‐gallium‐zinc oxide (IGZO)‐based electronic devices on an ultrathin (1.9 µm) poly(methyl methacrylate) (PMMA) substrate is introduced. The PMMA layer spin‐coated on an unmodified glass slide has no chemical interactions at the interface, resulting in weak adhesion. Therefore, the PMMA layer with the devices is readily peeled off the underlying glass slide without using any sacrificial layer. Thin film transistors (TFTs) and gas sensors are fabricated on a 1.9 µm thick PMMA substrate. The fabricated bottom‐gated IGZO TFTs exhibits excellent transistor performances with a mobility of 10.7 cm2 V−1 s−1, a threshold voltage of 8.4 V and an on/off current ratio of 5 × 105. The PMMA substrate having palladium (Pd)‐decorated IGZO H2 sensors is attached to the nonplanar substrates such as wrinkled hand glove and poly(vinyl chloride) (PVC) gas tubes, and the sensors demonstrate an excellent sensitivity of ≈106% at 5% H2 concentration at room temperature. Furthermore, both electronic devices show superior flexibility without any performance degradation even at a bending radius down to <1 mm.
High‐Performance Non‐doped OLEDs with Nearly 100 % Exciton Use and Negligible Efficiency Roll‐Off
Authors: Liu Huijun , Zeng Jiajie , Guo Jingjing , Nie Han , Zhao Zujin , Tang Ben Zhong 
Published: June 2018

AbstractNon‐doped organic light‐emitting diodes (OLEDs) possess merits of higher stability and easier fabrication than doped devices. However, luminescent materials with high exciton use are generally unsuitable for non‐doped OLEDs because of severe emission quenching and exciton annihilation in neat films. Herein, we wish to report a novel molecular design of integrating aggregation‐induced delayed fluorescence (AIDF) moiety within host materials to explore efficient luminogens for non‐doped OLEDs. By grafting 4‐(phenoxazin‐10‐yl)benzoyl to common host materials, we develop a series of new luminescent materials with prominent AIDF property. Their neat films fluoresce strongly and can fully harvest both singlet and triplet excitons with suppressed exciton annihilation. Non‐doped OLEDs of these AIDF luminogens exhibit excellent luminance (ca. 100000 cd m−2), outstanding external quantum efficiencies (21.4–22.6 %), negligible efficiency roll‐off and improved operational stability. To the best of our knowledge, these are the most efficient non‐doped OLEDs reported so far. This convenient and versatile molecular design is of high significance for the advance of non‐doped OLEDs.