bluuebunny/crossref_metadata_2025_split huggingface dataset:
To sink, swim, twin, or nucleate: A critical appraisal of crystal aggregation processes
Authors: Wieser Penny E. , Vukmanovic Zoja , Kilian Rüdiger , Ringe Emilie , Holness Marian B. , Maclennan John , Edmonds Marie 
Published: August 2019

Abstract
Crystal aggregates in igneous rocks have been variously ascribed to growth processes (e.g., twinning, heterogeneous nucleation, epitaxial growth, dendritic growth), or dynamical processes (e.g., synneusis, accumulation during settling). We tested these hypotheses by quantifying the relative orientation of adjacent crystals using electron backscatter diffraction. Both olivine aggregates from Kīlauea volcano (Hawaiʻi, USA) and chromite aggregates from the Bushveld Complex (South Africa) show diverse attachment geometries inconsistent with growth processes. Near-random attachments in chromite aggregates are consistent with accumulation by settling of individual crystals. Attachment geometries and prominent geochemical differences across grain boundaries in olivine aggregates are indicative of synneusis.
End-of-life communication: a nationwide study of bereaved parents’ perceptions
Authors: Lykke Camilla , Ekholm Ola , Schmiegelow Kjeld , Olsen Marianne , Sjøgren Per 
Published: August 2019

ObjectiveTo investigate bereaved parents’ perception of end-of-life communication with healthcare professionals after losing a child due to life-limiting diagnoses.MethodsA national register identified the causes of death of 951 children aged 0–18 years during the period 2012–2014. A previously described classification of life-limiting diagnoses identified 402 children. A modified version of the self-administered questionnaire 'To Lose a Child' was distributed to the parents of these 402 children, capturing their perceptions of communication with the healthcare professionals throughout the child’s disease trajectory and imminent death.ResultsA total of 193 bereaved parents, representing 38% of the identified children, participated in the study. Overall, 98% of the parents expressed the view that physicians should immediately disclose when curatively intended treatment options were exhausted. Some 79% of parents reported that information about their child’s incurable illness was given in an appropriate manner; however, 42% said that information about the child's imminent death was given too late. Finally, 31% felt deprived of the option to say goodbye to their child in their preferred manner, and 56% said that their child’s death was “a shock”.ConclusionsParents request accurate and timely information. However, a substantial number of the parents surveyed reported that healthcare professionals communicated too late about palliative care and end-of-life issues. Even though healthcare professionals strive to communicate effectively with dying children and their parents, barriers were identified that may hinder even the best of intentions. National guidelines addressing communication issues and improved education of healthcare professionals should form part of any future agenda.
Long-term impact of plain packaging of cigarettes with larger graphic health warnings: findings from cross-sectional surveys of Australian adolescents between 2011 and 2017
Authors: White Victoria M , Guerin Nicola , Williams Tahlia , Wakefield Melanie A 
Published: August 2019

ObjectiveTo assess the long-term impact of plain packaging (PP) of cigarettes with larger graphic health warnings (HW) introduced in December 2012 on adolescents’ relevant tobacco-related perceptions.MethodsCross-sectional school-based surveys of 12 to 17 year olds in 2011 (n=4413), 2013 (n=4423), 2014 (n=4576) and 2017 (n=4266). Students rated the character of four popular cigarette brands, indicated their agreement regarding brand differences in smoking ease, quitting, addictiveness, harmfulness and pack attractiveness and positive/negative perceptions of pack image. The frequency of students reading, attending to, thinking and talking about HW was assessed. Responses of students seeing cigarette packs in the previous 6 months (2011: 63%; 2013: 67%, 2014: 56%, 2017: 56%) were examined.ResultsSmoking prevalence declined from 2011 to 2017. Among students who had recently seen packs, cigarette packs were rated less positively and more negatively in 2017 than in 2011 (p<0.001) with ratings similar between 2013 and 2017. Positive character ratings for each brand reduced between 2011 and 2013 (ps<0.05) with further reductions between 2013 and 2017 (ps<0.05). Fewer students agreed, and more were uncertain, that brands differed in their smoking ease, addictiveness, harmfulness and pack attractiveness in 2017 than 2011. The frequency of students reading, attending, talking or thinking about HW did not change between 2011 and 2017.ConclusionsPP’s initial impact in reducing adolescent’s positive perceptions of cigarette packs and brand differences continued in the following years with tobacco packaging less appealing to young people in 2017 than 2011 and students more uncertain about brand differences.
MOND and natural scales of distance and mass
Authors: Żenczykowski Piotr 
Published: August 2019

We describe a MOND-related approach to natural scales of distance and mass, viewing it as a logical step following Planck’s modification of the Stoney system of units. The MOND-induced scales are not based on the strength of any physical interaction (electromagnetic, gravitational, or otherwise). Instead, they are specified by three physical constants of a general nature that define the scales of action, speed, and acceleration, i.e. [Formula: see text] — the Planck constant, [Formula: see text] — the speed of light and [Formula: see text] — the MOND acceleration constant. When the gravitational constant [Formula: see text] is added, two further distance scales (apart from the size of the Universe) appear: the Planck scale and a nanometer scale that fits the typical borderline between the classical and the quantum descriptions.
Vitrification of Human In-Vitro Matured Oocytes: Effects on Mitochondrial Ultrastructure and Oxygen Consumption
Authors: Han Shubiao , Han Wei , Zhang Xiaodong , Liu Junxia , Huang Guoning 
Published: August 2019

Background: This study was conducted to evaluate the impact of vitrification on mitochondrial of human IVM oocytes. Methods: A total of 401 immature oocytes were obtained from ovarian stimulated cycles, which were randomly divided into fresh and vitrification groups after IVM. According to the cultured time after thawing, the vitrification groups were divided into 0 hours (0 h), 2 hours (2 h), or 4 hours (4 h) subgroups. Mitochondrial morphology and oxygen consumption were compared among the four groups. After fertilization by ICSI, normal fertilization, cleaved embryos, and blastocyst formation rate were also calculated. Results: The mean gray value of mitochondria structure was significantly decreased in 0 h and 2 h groups when compared to control group (0.48 ± 0.09, 0.50 ± 0.36 vs. 0.61 ± 0.12, respectively; P [Formula: see text] 0.05), and recovered (0.61 ± 0.24 vs. 0.61 ± 0.12, P [Formula: see text] 0.05) in 4 h group. In addition, oxygen consumption was also significantly decreased in 0 h and 2 h groups compared to fresh (2.91 ± 0.77 fmol/s, 3.26 ± 1.34 fmol/s vs. 3.96 ± 1.44 fmol/s, respectively; P [Formula: see text] 0.05), and recovered after 4 h culture (3.96 ± 1.44 fmol/s vs. 4.41 ± 1.38 fmol/s, respectively; P [Formula: see text] 0.05). The percentage of normal fertilization and cleaved embryos were no differences among the four groups, however, blastocyst development rate was significantly lower in 0 h group. Conclusion: These results indicate that during the vitrification process, the oxygen consumption and mitochondrial structure of oocytes may undergo temporary dynamic changes, but appear to recover by 4 hours.
Chemotherapy-Induced Metastasis: Molecular Mechanisms, Clinical Manifestations, Therapeutic Interventions
Authors: Karagiannis George S. , Condeelis John S. , Oktay Maja H. 
Published: August 2019

AbstractChemotherapy offers long-term clinical benefits to many patients with advanced cancer. However, recent evidence has linked the cytotoxic effects of chemotherapy with the de novo elicitation of a prometastatic tumor microenvironment. This “modified” tumor microenvironment is triggered by a chemotherapy-driven cytokine storm or through direct effects of certain chemotherapeutics on stromal and/or immune cells, the most critical being tumor-associated macrophages. These chemotherapy-educated cells act as facilitators in tumor–host cell interactions promoting the establishment of distant metastasis. Certain clinical studies now offer substantial evidence that prometastatic changes are indeed identified in the tumor microenvironment of certain patient subpopulations, especially those that do not present with any pathologic response after neoadjuvant chemotherapy. Deciphering the exact contextual prerequisites for chemotherapy-driven metastasis will be paramount for designing novel mechanism–based treatments for circumventing chemotherapy-induced metastasis.
Clinical and Imaging Parameters Associated With Hyperacute Infarction Growth in Large Vessel Occlusion Stroke
Authors: Puhr-Westerheide Daniel , Tiedt Steffen , Rotkopf Lukas T. , Herzberg Moriz , Reidler Paul , Fabritius Matthias P. , Kazmierczak Philipp M. , Kellert Lars , Feil Katharina , Thierfelder Kolja M. , Dorn Franziska , Liebig Thomas , Wollenweber Frank A. , Kunz Wolfgang G. 
Published: August 2019

Background and Purpose—
Large vessel occlusion stroke leads to highly variable hyperacute infarction growth. Our aim was to identify clinical and imaging parameters associated with hyperacute infarction growth in patients with an large vessel occlusion stroke of the anterior circulation.

Methods—
Seven hundred twenty-two consecutive patients with acute stroke were prospectively included in our monocentric stroke registry between 2009 and 2017. We selected all patients with a large vessel occlusion stroke of the anterior circulation, documented times from symptom onset, and CT perfusion on admission for our analysis (N=178). Ischemic core volume was determined with CT perfusion using automated thresholds. Hyperacute infarction growth was defined as ischemic core volume divided by times from symptom onset, assuming linear progression during times from symptom onset to imaging on admission. For collateral assessment, the regional leptomeningeal collateral score (rLMC) was used. Clinical data included the National Institutes of Health Stroke Scale score on admission and cardiovascular risk factors. Regression analysis was performed to adjust for confounders.

Results—

Median ischemic core volume was 34.4 mL, and median hyperacute infarction growth was 0.27 mL/min. In regression analysis including age, sex, National Institutes of Health Stroke Scale, clot burden score, diabetes mellitus, smoking, hypercholesteremia, hypertension, Alberta Stroke Program Early CT Score, and rLMC scores, only the rLMC score had a significant, independent association with hyperacute infarction growth (adjusted β=−0.35;
P
<0.001). Trichotomizing patients by rLMC scores yielded 65 patients with good (rLMC >15), 67 with intermediate (rLMC 11–15) and 46 with poor collaterals (rLMC <11) with an infarction growth of 0.17 mL/min, 0.26 mL/min, and 0.41 mL/min, respectively.

Conclusions—
Hyperacute infarction growth strongly depends on collaterals. In primary stroke centers, hyperacute infarction growth may be extrapolated to estimate the stroke progression during transfer times to thrombectomy centers and to support decisions on which patients to transfer.
An Implicit Algebraic Turbulence Closure Scheme for Atmospheric Boundary Layer Simulation
Authors: Shi Xiaoming , Enriquez Rica Mae , Street Robert L. , Bryan George H. , Chow Fotini Katopodes 
Published: August 2019

Abstract
Turbulence parameterization plays a critical role in the simulation of many weather regimes. For challenging cases such as the stratocumulus-capped boundary layer (SCBL), traditional schemes can produce unrealistic results even when a fine large-eddy-simulation (LES) resolution is used. Here we present an implicit generalized linear algebraic subfilter-scale model (iGLASS) to better represent unresolved turbulence in the simulation of the atmospheric boundary layer, at both standard LES and so-called terra incognita (TI) resolutions. The latter refers to a range of model resolutions where turbulent eddies are only partially resolved, and therefore the simulated processes are sensitive to the representation of unresolved turbulence. iGLASS is based on the truncated conservation equations of subfilter-scale (SFS) fluxes, but it integrates the full equations of the SFS turbulence kinetic energy and potential energy to retain “memory” of the SFS turbulence. Our evaluations suggest iGLASS can perform significantly better than traditional eddy-diffusivity models and exhibit skills comparable to the dynamic reconstruction model (DRM). For a neutral boundary layer case run at LES resolution, the simulation using iGLASS exhibits a wind profile that reasonably matches the similarity-theory solution. For an SCBL case with 5-m vertical resolution, iGLASS maintains more realistic cloud water profiles and boundary layer structure than traditional schemes. The SCBL case is also tested at TI resolution, and iGLASS also exhibits superior performance. iGLASS permits significant backscatter, whereas traditional models allow forward scatter (diffusion) only. As a physics-based approach, iGLASS appears to be a viable alternative for turbulence parameterization.
Impacts of Central Pacific El Niño on Southern China Spring Precipitation Controlled by its Longitudinal Position
Authors: Jiang Feng , Zhang Wenjun , Geng Xin , Stuecker Malte F. , Liu Chao 
Published: August 2019

ABSTRACT
Here we investigate the response of boreal spring precipitation over southern China (SPSC) to central Pacific (CP) El Niño based on observational datasets. While there is enhanced precipitation over southern China during the decaying boreal spring of eastern Pacific (EP) El Niño events, so far no clear precipitation response has been detected during the same decaying stage for CP El Niño composites. Here we show that around half of the CP El Niño events coincide with enhanced SPSC (wet CP El Niño), while the other half are accompanied by reduced SPSC (dry CP El Niño). These two types of CP El Niño events bear dramatically different evolution features in their respective tropical sea surface temperature anomaly (SSTA) patterns. Wet CP El Niño events are characterized by an SSTA longitudinal position confined to the tropical central-eastern Pacific. In contrast, dry CP El Niño events exhibit a clear westward propagation of SSTAs during their evolution, with maximum SSTAs located to the west of the date line after their mature phase. These different longitudinal positions of positive SSTAs during their decaying phase result in distinct meridional structures of the tropical Pacific convection anomalies as well as the ENSO combination mode (C-mode) response. An anomalous low-level anticyclone is evident over the western North Pacific during wet CP El Niño events during their decaying phase, while an anomalous cyclonic circulation is found for dry CP El Niño events. We emphasize that the impacts of CP El Niño on the SPSC depend crucially on the simultaneous zonal location of warm SSTAs in the tropical Pacific.
Diurnal Variations of Low-Level Winds and Precipitation Response to Large-Scale Circulations during a Heavy Rainfall Event
Authors: Zeng Wenxin , Chen Guixing , Du Yu , Wen Zhiping 
Published: August 2019

AbstractA succession of MCSs developed during the last week of October 2016 and produced extreme heavy rainfall in central China. The event underwent an evident shift from a mei-yu-like warm scenario to an autumn cold scenario. Diurnal cycles of rainfall and low-level winds may be modulated by the shifting of large-scale atmospheric conditions. We conducted observational analyses and numerical experiments to examine how large-scale circulations influenced rainfall systems through diurnally varying processes. The results show that, in the first half (warm) period of the event, intense rainfall mostly occurred in eastern-central China with an early morning peak. It was closely related to a nocturnal southwesterly low-level jet (NLLJ) on the flank of the western Pacific subtropical high. The NLLJ formed near midnight in southern China where ageostrophic wind rotated clockwise due to Blackadar’s inertial oscillation. The NLLJ extended downstream to central China during the predawn hours due to the horizontal advection of momentum. Both the formation and extension of the NLLJ were supported by an enhanced subtropical high that provided relatively warm conditions with surface heating for boundary layer inertial oscillation and strong background southwesterly winds for momentum transport. The NLLJ induced MCSs at its northern terminus where the low-level ascent, moisture flux convergence, and convective instability were enhanced during the predawn hours. In the second half period with an intrusion of cold air, the diurnal amplitude of low-level winds became small under relatively cold and cloudy conditions. Moderate rainfall tended to occur in western-central China with a peak after midnight, most likely due to frontogenetic processes, upslope lifting, and nighttime cloud-top cooling.
Diagnostic value of heat shock protein 90α and squamous cell carcinoma antigen in detection of cervical cancer
Authors: Han Songtao , Cheng Zhenzhen , Zhao Xiaoqun , Huang Yanchun 
Published: August 2019

Objective To ascertain plasma levels of heat shock protein 90α (HSP90α) and squamous cell carcinoma antigen (SCC-Ag) and their diagnostic potential in cervical cancer. Methods In a cross-sectional study, patients’ cervical tissue samples were screened for high risk (HR) human papilloma virus (HPV) DNA and underwent a thinprep-liquid based cytology test (TCT). Plasma samples were analysed by enzyme-linked immunosorbent assay (ELISA) for HSP90 α and SCC-Ag levels. Results Of the 295 women who underwent screening, 75 were healthy controls 75 (HR-HPV−ve TCT−ve), 110 were HR-HPV+ve, TCT−ve and 110 were HR-HPV+ve TCT+ve. There were significant differences between levels of HSP90α and SCC-Ag proteins across the patient groups with those positive for cervical cancer having the greatest levels of proteins compared with other groups. For patients with high grade SCC there was a significant correlation between levels of HSP90α and SCC-Ag. The area under the ROC curve for combined HSP90α*SCC-Ag was the largest compared with the single proteins. Using a cut-off value of 16.4 ng/ml to delineate cervical cancer diagnosis, the sensitivity and specificity of HSP90α*SCC-Ag were 90.3% and 95.1% respectively. Conclusion Plasma HSP90α protein levels correlated well with SCC-Ag levels in patients with cervical cancer and the combination of HSP90α*SCC-Ag may be a useful diagnostic biomarker.
Association between 24-hour diastolic blood pressure and renal function in patients receiving treatment for essential hypertension
Authors: Sveceny J , Charvat J , Hrach K , Horackova M , Schück O 
Published: August 2019

Objectives To evaluate the association between diastolic blood pressure (BP), measured by 24-hour ambulatory blood pressure monitoring (ABPM) and renal function in patients receiving treatment for essential hypertension. Methods In this cross-sectional study, ABPM, transthoracic echocardiography, estimated glomerular filtration rate (eGFR) on the basis of serum cystatin C (eGFRcyst) and the renal resistive index (RRI) were measured in patients with essential hypertension. Results The cohort consisted of 105 patients (39 men, 66 women), with a mean ± SD age of 58 ± 12 years who had been receiving treatment for 11 ± 8 years. 24-hour diastolic BP significantly positively correlated with eGFRcyst and negatively correlated with RRI. No correlation was observed with 24-hour systolic BP values. 24-hour diastolic BP values ≤70 mmHg were associated with eGFRcyst ≤60 ml/min/1.73 m2 (i.e., decreased GFR). Conclusion 24-hour diastolic BP values were significantly associated with markers of kidney function in patients receiving treatment for essential hypertension and values ≤70 mmHg may be associated with subnormal eGFRcyst.
Relationships between smoking duration, smoking intensity, hypothetical tobacco price increases, and smoking habit change intention among current smokers in Shanghai
Authors: Wang Ruiping , Jiang Yonggen , Li Xin , Zhao Qi , Zhu Meiying , Guan Ying , Zhao Genming 
Published: August 2019

Objectives We conducted a cross-sectional study to explore the effect of a hypothetical tobacco retail price increase on smoking habit change intention, and the role of smoking duration and intensity in smoking change intention. Methods In 2016 and 2017, we collected questionnaire data from 36,698 residents aged over 18 years in Songjiang district, Shanghai. Chi-square tests and weighted logistic regression were used for data analyses. Results The prevalence of current smoking was 19.78% (men: 48.36% and women: 0.22%). A total of 10.83% (men: 10.89% and women: 2.04%) and 9.39% of smokers (men: 9.42% and women: 6.12%) expressed the intention to smoke less or quit, respectively, given tobacco retail price increases. If the current tobacco retail price doubled, 75% of smokers stated that they would smoke less and 60% of smokers would consider quitting. Smokers with longer smoking duration and lower smoking intensity were more sensitive to tobacco price increases and more likely to change their smoking habits. Conclusions An increase in tobacco retail prices could induce some smokers to change their smoking behavior, particularly those with longer smoking duration and lower smoking intensity. A tobacco retail price increase is recommended, which should apply to all cigarette brands.
Exploring how therapeutic horse riding improves health outcomes using a realist framework
Authors: Martin Rachelle A , Graham Fiona P , Levack William MM , Taylor William J , Surgenor Lois J 
Published: August 2019

Introduction Evaluating how therapeutic horse riding improves health for children experiencing disability is made complex by a lack of clarity around mechanisms of treatment effect. This research develops an explanatory theory outlining how health outcomes may be optimised, by exploring what works for which riders, under what conditions and how. Method Within a realist research framework, we undertook three phases of study using a mix of qualitative and quantitative data collection and analysis approaches. Findings were then integrated into an overall evaluative account. Results Riders with a range of impairments ( n = 32; aged 5 to 17 years), caregivers ( n = 29) and therapeutic horse riding providers ( n = 16) participated. Three key mechanisms of intervention effect are proposed: (1) therapeutic horse riding facilitates development of a rider’s self-concept through opportunities for accessible, meaningful participation; (2) the context in which therapeutic horse riding is provided promotes a focus on riders’ capacities and strengths and (3) therapeutic horse riding provides opportunities for a broad range of learning experiences. Conclusion Therapeutic horse riding provides opportunities for meaningful occupational participation for children experiencing disability. Ensuring that the physical and ideological context in which therapeutic horse riding is provided focuses on a rider’s capacities and strengths will enhance self-concept development and participation outcomes.