bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the MMP7 –181A>G promoter polymorphism with early onset of chronic obstructive pulmonary disease
Authors: Tacheva T , Dimov D , Anastasov A , Zhelyazkova Y , Kurzawski M , Gulubova M , Drozdzik M , Vlaykova T 
Published: May 2018

Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by decreased air flow and is associated with abnormal chronic inflammation in the airways and extensive tissue remodeling. Matrix metalloproteinase-7 (MMP7) is produced primarily by the epithelium of many organs, including the lungs. A functional MMP7 –181A>G (rs11568818) promoter polymorphism influences the binding of nuclear regulatory proteins modulating the transcription of the gene. In this study, we genotyped 191 patients with COPD for MMP7 –181A>G single nucleotide polymorphism (SNP) and 215 control subjects using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and explored the role of that polymorphism as a risk factor for COPD. There were no differences in the genotype and allele distribution of the MMP7 –181A>G SNP between the COPD patients and control groups (p = 0.341 and p = 0.214). However, the carries of the G allele (AG and GG genotypes), appeared to develop COPD significantly earlier than those with the AA genotype (61.01 ± 10.11 vs. 64.87 ± 9.00 years, p = 0.032). When the genotype distribution was studied only in the groups of patients (n = 76) and controls (n = 106) younger than 60 years, we found significantly higher frequency of the carriers of the G allele in COPD patients than in the controls, determining about a 3-fold higher risk for COPD [odds ratio (OR) –3.33, 1.36-8.14, p = 0.008 for GG, and OR = 2.91, 1.38-6.13, p = 0.005 for AG+GG]. Based on our results, the MMP7 –181A>G promoter variant may influence early development of COPD. This effect could be attributed to the increased production of the enzyme resulting in enhanced airway wall protein degradation and injury.
Detection of allelic variants of the POLE and POLD1 genes in colorectal cancer patients
Authors: Pätzold LA , Bērziņa D , Daneberga Z , Gardovskis J , Miklaševičs E 
Published: May 2018

Abstract
Incidence of colorectal cancer is high worldwide and it mostly occurs as an accumulation of environmental factors and genetic alterations. Hereditary colorectal cancer can develop as a part of a hereditary syndrome. There is a suspected correlation between colorectal cancer and allelic variants of the POLE and POLD1 genes. The aim of the present study was to look for associations between the allelic variants in the POLE and POLD1 genes and colorectal cancer. One thousand, seven hundred and forty-nine DNA samples from colorectal cancer patients were collected from 2002 to 2013. Samples were divided in three groups: hereditary colorectal cancer patients, patients with different hereditary cancer syndromes in their families and patients with no cancer history in their families. The DNA samples were screened for allelic variants of POLE rs483352909 and POLD1 rs39751463 using denaturing high performance liquid chromatography (DHPLC). All patients were negative for allelic variants rs483352909 of the POLE gene and rs397514632 of the POLD1 gene. One allelic variant rs373243003 in the POLE gene and one novel duplication of four nucleotides at the excision site between intron and exon (c.1384-5dupCCTA) in the POLD1 gene, was found. We could not detect or confirm the connection between the genetic variants in the POLD1 and POLE genes and colorectal cancer patients, but we detected a novel genetic variant with an unknown significance.
Galactosialidosis in a newborn with a novel mutation in the CTSA gene presenting with transient hyperparathyroidism
Authors: Okulu E , Tunc G , Eminoglu T , Erdeve O , Atasay B , Arsan S 
Published: May 2018

Abstract
Galactosialidosis is a lysosomal storage disease caused by deficiency of protective protein that is encoded by the cathepsin A (CTSA) gene localized on chromosome 20q13.1. Mutations of this gene are the cause of galactosialidosis that result in loss of function of protective protein. Galactosialidosis is an autosomal recessive inherited disease and has been divided into three subtypes based on age of onset and the severity of clinical manifestations. We report an early infantile form of galactosialidosis in a newborn with a novel mutation on the CTSA gene.
Polymorphism of the ADRB2 rs1042713 gene is not associated with spontaneous preterm birth: Analyses in a Slovenian sample and meta analysis
Authors: Peterlin A , Maver A , Jan Z , Lovrecic L , Tul N , Peterlin B 
Published: May 2018

Abstract
The β-2-adrenergic receptor (ADRB2) gene has an important impact on smooth muscle relaxation, including the smooth muscles of the uterus. The results of previously published studies of the association between the ADRB2 rs1042713 polymorphism and spontaneous preterm birth (SPTB) were inconsistent. We evaluated the association between ADRB2 and SPTB in a case-control association study in a Slovenian sample population and performed a meta analysis of previously published studies. No association was found between the polymorphism in the ADRB2 gene and SPTB in the Slovenian sample of 98 SPTB patients and 135 controls under dominant [χ2 = 0.01, p = 0.92, odds ratio (OR) = 1.03, 95% confidence interval (95% CI) = 0.52-2.04), recessive (χ2 = 0.01, p = 0.92, OR = 0.98, 95% CI = 0.57-1.70) and codominant genetic models (χ2 = 0.01, p = 0.92, OR = 0.99, 95% CI = 0.59-1.68). The meta analysis of a pooled sample of 404 SPTB patients and 878 controls suggested no association of ADRB2 polymorphism and SPTB under dominant (OR = 1.12, 95% CI = 0.81-1.54) and recessive genetic models (OR = 0.84, 95% CI = 0.64-1.12). These findings suggest no association between the ADRB2 rs1042713 gene polymorphism and SPTB. Further association studies with larger sample sizes are needed.
Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients
Authors: Tuna A , Ozturk G , Gerceker TB , Karaca E , Onay H , Guvenc SM , Cogulu O 
Published: May 2018

Abstract
Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients.
Przepowiadanie słowa w kontekście przemian religijności młodych Niemców i Polaków
Authors: Wilkosz Michał 
Published: May 2018

Badania nad warunkami życia i religijnością młodzieży niemieckiej i polskiej wskazują na postępujące przemiany, jakie w obszarze życia religijnego dokonują się wśród współczesnego pokolenia młodych Niemców i Polaków. Zasadniczo można je uporządkować w dwóch grupach: 1) odnoszące się jednocześnie do młodzieży polskiej i niemieckiej, 2) traktujące osobno każdą z grup młodzieży.W obliczu przemian zachodzących w religijności młodych Polaków i młodych Niemców należy uwzględniać propozycje takich form ewangelizacyjnych, które odpowiadają mentalności i duchowym potrzebom młodej generacji. Przede wszystkim należy zmienić podejście do sposobu przepowiadania, a mianowicie nie tylko dbać o merytorczną stronę przekazu ale także uwzględnić nowe formy i konteksty głoszenia.
Capacidades institucionales para la vinculación científico-tecnologica en una universidad de gestión estatal
Authors: Fernanda Di Meglio 
Published: May 2018

Desde una perspectiva teórica proveniente de la ciencia política, en este artículo se identifican y analizan las distintas capacidades institucionales universitarias implicadas en el desarrollo de la política de vinculación científico-tecnológica en una universidad argentina de gestión estatal. Los datos empíricos en los que se basa esta investigación se generaron a través de análisis documental proveniente de la universidad objeto de estudio y se complementó con entrevistas semi-estructuradas aplicadas a distintos funcionarios vinculados a la temática. Los resultados obtenidos muestran que la universidad estudiada desarrolló capacidades institucionales vinculadas a la creación de una estructura de interacción ad hoc que cumple la función de enlace entre el entorno y la universidad, a la implementación de una política de incentivos para promover la participación de la comunidad
Rancang Bangun Alat Penerjemah ASL (American Sign Language) dengan Sensor Flex Berbasis Mikrokontroler ATmega2560
Authors: Prasetijo Agung Budi , Dias Muhamad Y. , Eridani Dania 
Published: May 2018

Deaf or hard-of-hearing people have been using The American Sign Language (ASL) to communicate with others. Unfortunately, most of the people having normal hearing do not learn such a sign language; therefore, they do not understand persons with such disability. However, the rapid development of science and technology can facilitate people to translate body or part of the body formation more easily. This research is preceded with literature study surveying the need of sensors embedded in a glove. This research employs five flex sensors as well as accelerator and gyroscope to recognize ASL language having similar fingers formation. An Arduino Mega 2560 board as the central controller is employed to read the flex sensors’ output and process the information. With 1Sheeld module, the output of the interpreter is presented on a smartphone both in text and voice. The result of this research is a flex glove system capable of translating the ASL from the hand formation that can be seen and be heard. Limitations were found when translating sign for letter N and M as the accuracy reached only 60%; therefore, the total performance of this system to recognize letter A to Z is 96.9%.
Aktivitas Antioksidan Sirup Buah Karamunting (Rhodomyrtus Tomentosa) dengan Variasi Penambahan Asam Sitrat
Authors: Rifkowaty Encik Eko , Wardanu Adha Panca , Hastuti Ningrum Dwi 
Published: May 2018

Karamunting (Rhodomyrtus Tomentosa)merupakan salah satu tanaman yang tumbuh liar di daerah kabupaten Ketapang Kalimatan Barat. Tanaman ini memiliki buah yang terasa manis dan mengandung antioksidan tinggi karena memiliki warna buah masak merah hingga kehitam-hitaman. Buah karamunting belum termanfaatkan secara optimal, sehingga dengan diolah menjadi produk sirup dapat meningkatkan nilai ekonomis secara kualitas maupun secara kuantitas. Pada penelitian ini dilakukan pembuatan sirup dari buah karamunting dengan variasi penambahan asam sitrat 0, 0,05, 0,1%. Asam sitrat diharapkan mampu meningkatkan ekstraksi kandungan antioksidan sirup buah karamunting. Sirup yang dihasilkan kemudian dilakukan analisa gula reduksi dan antioksidan menggunakan DDPH. Persentase antioksidan tertinggi dilakukan uji lanjutan menggunakan GC-MS. Kandungan antioksidan buah, sirup karamunting variasi penambahan asam sitrat 0%, 0,05%, dan 0,1% dengan pengujian menggunakan DPPH berturut-turut 98,84%, 43,87%, 81,99%, dan 86,47%, sedangkan gula reduksi 0,21%, 3,62%, 4,11%, dan 11,90%. Berdasarkan GC-MS senyawa yang paling dominan dari bahan baku buah karamunting adalah hydroxy methyl furfurole (41,14%), dan senyawa-senyawa yang dihasilkan dari sirup karamunting dengan konsentrasi asam sitrat 0,1% adalah acetil acid 4,5% dan hydroxy methyl furfurole 3,5%.
Diagnósticos de enfermagem em portadores de hipertensão arterial na atenção primária
Authors: Mendes Fabrizio Do Amaral , Silva Marlucilena Pinheiro da , Ferreira Cecília Rafaela Salles 
Published: May 2018

<p><strong>RESUMO: Objetivo</strong>: Identificar diagnósticos de enfermagem (DEs) em portadores de hipertensão arterial atendidos na Unidade Básica de Saúde/UNIFAP. <strong>Metodologia:</strong> Estudo descritivo de abordagem quantitativa, realizado em uma unidade básica de saúde com portadores de Hipertensão Arterial Sistêmica cadastrados e acompanhados pelo programa de Doenças Crônicas do Ministério da Saúde, no período de janeiro à maio de 2017. <strong>Resultados</strong>: 25 hipertensos passaram por consulta de enfermagem, a maioria era do sexo feminino (56%), faixa etária que variava de 50 a 69 anos, média de idade 60,4 (±14) anos, casados (44%), não alfabetizados (40%) e de renda familiar de 1 a 2 salários mínimos (100%). Os diagnósticos de enfermagem mais frequentes foram : Risco de Função Cardiovascular Prejudicada-100%; Estilo de Vida Sedentário-68%; Falta de Adesão-60%; Conhecimento deficiente-60% e Sobrepeso-48% <strong>Conclusão:</strong> A identificação dos diagnósticos de enfermagem, colabora para o avanço científico desta área e melhora o atendimento para o usuário hipertenso, pois promove um cuidado planejado, facilitando sua implementação e favorecendo a avaliação do mesmo, contribuindo para redução da morbimortalidade advinda de complicações da HAS, provenientes da falta de adesão pelos hipertensos na Atenção Primária.</p>
Koroner Bypass Operasyonlarında Safen Ven Grefti Hazırlama Tekniklerinin Karşılaştırılması
Authors: Şen Onur , Kadiroğulları Ersin 
Published: May 2018

Amaç: Bu çalışmada koroner bypass cerrahisi (CABG) sırasında safen ven grefti
hazırlanırken tek ya da iki bacaktan safen ven grefti çıkartmanın bacak ağrısı,
sellülit ve ödem açılarından aralarında
fark olup olmadığı araştırıldı.Gereç ve Yöntemler: CABG yapılacak ardışık 80 hasta çalışmaya alındı. Kırkar
hastadan oluşan iki grup oluşturuldu. Gurup-1 de safen ven grefti tek bir bacaktan ve diz eklemini
geçecek bir insizyonla hazırlandı. Gurup-2 de ise safen ven grefti hazırlanırken her iki
bacaktan birer tane greft alınacak şekilde, diz eklemini geçmeyen insizyonlar
yapıldı. Olguların insizyon yapılan bacak çevreleri,
preoperatif evrede, postoperatif 1. hafta ve 1. aylarda, insizyonun 15. cm’den
ölçüldü. Hastalar postoperatif üçüncü
günde, mobilize olduklarında, bacak ağrısı sorgulandı. Bulgular: Her iki grupta da bacak çevresi ölçüm değerleri ve
sellülit tablosu görülmesi benzer bulundu ve istatistiksel fark saptanmadı (p &gt; 0.05). Ancak bacak ağrısı yönünden birinci
gruptaki hastaların şikayetlerinin diğer gruba göre daha fazla olduğu saptandı
(p &lt; 0.05).

Sonuç: Koroner bypass operasyonu için safen ven grefti hazırlanırken cerrahi
insizyon seviyesinin diz eklem seviyesi üzerine çıkmaması, hastaların olası bacak
ağrısı şikayetinin daha az olmasını sağlayacaktır.
Los cien años del Hospital Víctor Larco Herrera
Authors: Stucchi-Portocarrero Santiago 
Published: May 2018

El actual Hospital Víctor Larco Herrera fue inaugurado el 1 de enero de 1918, como Asilo Colonia de la Magdalena, en un contexto de transición entre el alienismo del siglo XIX y una psiquiatría que reclamaba su lugar entre las especialidades médicas, a la vez que el liderazgo en la conducción de los hospitales, como representante de la ciencia positiva. La fundación del nuevo establecimiento fue considerada “la segunda revolución psiquiátrica” en el Perú, y generó muchas expectativas, inspirándose en la terapia por el trabajo y en los principios de no restricción y puertas abiertas.
An Experimental Configuration to Probe for Lorentz Symmetry Violation in Electrons Using Trapped Yb+ Ions
Authors: Schlossberger Noah Kurt , Richerme Phil 
Published: May 2018

Since extensions of the standard model have been developed that predict violations of local Lorentz invariance (LLI), precision measurement groups have been working to reduce experimental bounds of the associated matrix element. Using an analogue of the Michelson-Morley test with trapped Ca+ ions, the current bound has been set at one part in 1018. However, by instead using Yb+ ions, which have highly stable electronic states for storing quantum information compared to their counterparts and exhibit enhanced effects of LLI breaking asymmetries, we can push the bounds to one part in 1023. In this article, we outline a configuration for such an experiment and offer solutions to experimental concerns. We develop an algorithm for state creation, manipulation, and measurement that minimizes measurement time and transition uncertainty. We also discuss necessary hardware for trapping and manipulating ions including a vacuum system, a Paul trap and the associated electrode voltage supplies, and an optics system for generating and applying transition pulses. The experiment is specifically designed to utilize the existing ion trap hardware in place at the Richerme lab at Indiana University Bloomington.
Endocrine Disruption: Why Is It So Complicated?
Authors: Lister Andrea L. , Van Der Kraak Glen J. 
Published: May 2018

Abstract
The intricate nature of the vertebrate endocrine system creates several challenges that impede the understanding of the threats that endocrine disrupting substances (EDS) may pose to both humans and wildlife. While there are many similarities in the organization of endocrine communication across vertebrate classes, there are differences in hormonal activities and regulated events which makes generalizing EDS effects across species difficult. Aspects of endocrine functioning that may be affected by EDS include the biosynthesis, transport or availability, and metabolism of hormones. Also, EDS may interact with hormone receptors, which is a feature exploited by researchers as a screening method to identify potential EDS. There are many factors to consider in regards to the effects of potential EDS on endocrine functioning, including the timing of exposure, species-specific differences, and a multitude of other factors, which may impinge directly on the physiological endpoints used to determine if endocrine disruption has occurred. It is important to understand the status of the endocrine system before attempting to interpret reproductive status or the general health of the population. This paper provides an overview of the endocrine physiology of vertebrates and a description of the mechanisms by which EDS may affect endocrine function. As well, some of the factors that complicate our understanding of the relationship between exposure to EDS and compromised health in different vertebrate species are included.
Endocrine Disrupting Substances and Ecological Risk Assessment of Commercial Chemicals in Canada
Authors: Sutcliffe Roger 
Published: May 2018

Abstract
The ecological risk assessment of commercial chemicals in Canada by the regulatory programs of the Commercial Chemicals Evaluation Branch, Environment Canada, are based on results from traditional toxicity data (e.g., lethality, effects to growth or reproduction). Some of the chemicals under consideration are known to alter endocrine systems in exposed organisms; however, effects to the endocrine system are used only as additional supporting information. Presently, there are no internationally accepted methodologies or tests for endocrine disrupting substances that can be used by these regulatory programs. The need for research with respect to hormone disrupting substances has been recognized in the revised Canadian Environmental Protection Act, 1999 (CEPA 1999). This paper describes the framework for the ecological risk assessment of new and existing substances and identifies issues and research needs in both screening level and in-depth ecological risk assessments with respect to the identification and assessment of potentially endocrine disrupting substances.
A Canadian Perspective on Endocrine Disrupting Substances in the Environment
Authors: Servos Mark , Delorme Peter , Fox Glen , Sutciffe Roger , Wade Michael 
Published: May 2018

Abstract
Although reproduction and development are major endpoints for environmental and human health assessments in many federal government programs, growing concern about risks posed by endocrine disrupting substances (EDS) has highlighted the need to detect subtle effects mediated through endocrine systems. Internationally, screening and testing programs in the United States, Japan and Europe, and the activities of international agencies such as the OECD, will have a profound influence on how Canada will address this issue in the future. It is critical that Canada be proactive, identify knowledge gaps from a Canadian perspective, and anticipate international developments that may influence Canadian policy. The complexity and urgency of the EDS question spurred the Five Natural Resource Departments Endocrine Disrupting Substances (5-NR EDS) Working Group to hold a multi-departmental, multi-stakeholder, workshop to address key issues in assessing risks of EDS to Canadians and the Canadian environment. The following is a summary of the major conclusions, research priorities and recommendations from the workshop held at the Grandview Inn, in Huntsville, Ontario, February 13–17, 2000.
Short-Term Effects of Low pH on the Microfauna of an Activated Sludge Wastewater Treatment System
Authors: Baldwin Damian D. , Campbell Christine E. 
Published: May 2018

Abstract
Optimum pH for biological (e.g., activated sludge) wastewater treatment is stated to lie between pH 6.5 and 8.0; however, the pH of processed effluent from thermomechanical pulp mills is closer to 4.5 and 5.5. Consequently, pH adjustment of effluent is required with associated costs. The ability of the microfaunal community (protozoa and metazoa) of activated sludge to survive at pH levels below 6.5 was evaluated with samples collected from Corner Brook Pulp and Paper Ltd. (Newfoundland, Canada). Effect of pH was examined at “high pH” (4.5, 5.5 and 6.5 control) and “low pH” (2.5, 3.5 and 6.5 control) under “summer” temperatures of 30°C and “winter” temperatures of 15°C, with impacts assessed after 1 h and 24 h exposure. Effect of pH was found to be temperature-dependent: pH levels down to 4.5 appeared to have little impact on microfaunal abundances at 30°C , but a number of microfauna were negatively affected at 15°C. Low pH levels of 2.5 and 3.5 were detrimental to the population densities of most microfauna. Adverse pH effects were more marked with increased exposure in some cases. An acid-neutralizing ability may be inherent in the activated sludge, as treatment pH increased over 24 h.