bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of combining dental interventions with dietary and exercise advice on waist circumference in patients with the metabolic syndrome: Protocol for a randomized controlled trial
Authors: Suzuki Hiroyuki , Komagamine Yuriko , Kanazawa Manabu , Iwaki Maiko , Doke Midori , Mizuno Tetsuya , Sema Manabu , Okayasu Kaori , Miyazaki Yasunari , Minakuchi Shunsuke 
Published: September 2019

Abstract
Background

Metabolic Syndrome (MetS) associated with cardiovascular diseases have been focused on by researchers. Although various studies have investigated its relationship with the oral environment, the effects of dental interventions for MetS remain unclear. The aim of this trial is to investigate whether prosthetic or periodontal treatment combined with dietary and exercise advice can improve waist circumference, a surrogate measure of the syndrome. The null hypothesis is that there will be no difference in waist circumference between participants who receive prosthetic or periodontal treatment combined with dietary and exercise advice and those who receive only dietary and exercise advice.

Methods

This is a single-center, single-blinded, parallel, randomized controlled trial. Participants are randomly allocated to an intervention group (dietary and exercise advice plus prosthetic or periodontal treatment) or a control group (dietary and exercise advice only). Outcome measures include waist circumference; blood pressure; serum triglyceride, serum HDL/LDL cholesterol, fasting blood glucose, and HbA1c assessment using blood tests; Anthropometric measurements using bioelectrical impedance; health-related quality of life assessment using MOS 36-Item Short-Form Health Survey; oral-health-related quality of life assessment using Oral Health Impact Profile-14 and Geriatric Oral Health Assessment Index; food and nutrient intake assessment using brief-type self-administered diet history questionnaire; periodontal assessment using probing pocket depth and bleeding on probing. Objective masticatory function assessment using a color-changeable chewing gum and a gummy jelly was conducted for the participants who received prosthetic treatment. Outcome measures are to be implemented at three time points: at baseline and at 1 and 3 months after intervention. Differences between two groups in each assessment is compared using the Student’s t-test. Within group, the change between each assessment time is compared using the Tukey’s test.

Discussion

This trial could help to establish a new preventive method for the MetS that can be delivered by dental practitioners. Moreover, the findings are expected to reinforce the contribution of dentistry to extending healthy life expectancy.
Changing face of Candida colonization pattern in pediatric patients with hematological malignancy during repeated hospitalizations, results of a prospective observational study (2016-2017) in Shiraz, Iran
Authors: Hamzavi Sedigheh , Amanati Ali , Badiee Parisa , Kadivar Mohammad Rahim , Jafarian Hadis , Ghasemi Fatemeh , Haghpanah Sezaneh , Dehghani Mansooreh , Baghani Abbas Norouzian 
Published: September 2019

Abstract
Background: Surveillance of current changes in the epidemiology of Invasive Fungal Diseases (IFDs) as an important component of the antifungal stewardship programs (ASP), requires careful regular monitoring, especially in high-risk settings such as oncology centers. This study aimed to examine Candida colonization status and corresponding current changes in children with malignancy during repeated admissions and also investigate the possible epidemiological shifts after the implementation of ASP. Methods: In this prospective observational study, all eligible patients younger than 18 years were recruited during 2016-2017 at Amir Medical Oncology Center (AMOC) in Shiraz, Iran. Totally, 136 patients were enrolled and 482 samples were collected from different sites (oral/nasal discharges, urine and stool). Weekly regular sampling was carried out during hospitalization. Candida colonization status and epidemiological changes were monitored during repeated admissions. Samples were cultivated on Sabouraud Dextrose agar medium and identified by Polymerase Chain Reaction -Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Estimated Candida colonization incidence was 59.9% (82/136) in our patients. Candida colonization was found to be higher in oral cavity and rectum than that in nasal cavity. Among those long-term follow ups and repetitive hospitalizations, a significant number of patients exhibited changes in their colonization patterns (37.7%). Candida colonization did not reveal any significant relationship with age, sex, oncologic diseases and degree of neutropenia. C. albicans (72.0%) was found as the most common Candida species in colonized patients, followed by C. krusei, C. kefyr, C. glabrata and C. parapsilosis. Conclusion: Given the high incidence of Candida infections in children with cancers, close monitoring of epidemiologic changes is essential for judicious management, based on local surveillance data and improvement of overall quality of care in high risk patients. Key Words: Candida Albicans, Fungal Colonization, Pediatric Leukemia
Burden, clinical outcomes and predictors of time to in hospital mortality among adult patients admitted to stroke unit of Jimma university medical center: a prospective cohort study
Authors: Fekadu Ginenus , Chelkeba Legese , Kebede Ayantu 
Published: September 2019

Abstract
Background: The global burden of stroke epidemiology is changing rapidly. Over the 1990–2013 periods, there was a significant increase in the absolute number of deaths and incident events of stroke. The burden of stroke varies in Ethiopia between regions and over time. Hence, this study was aimed to assess the burden, clinical outcomes and predictors of time to in hospital mortality among stroke patients.
Methods: A prospective cohort study was carried at stroke unit of Jimma University Medical Center (JUMC) from March 10- July 10, 2017. The outcome of interest was mortality and time to death. Data was analyzed using SPSS version 20. Multivariable Cox regression was used to identify the predictors of in hospital mortality and time to death from hospital arrival. Predictor variables with P< 0.05 was considered statistically significant.
Results: A total of 116 eligible stroke patients were followed over 4 months. The mean age of patients was 55.1+14.0 years and males comprised of 73 (62.9%). Stroke accounted for 16.5 % of total medical admissions. Among the 116 patients with stroke, 91 (78.4%) were discharged alive making in hospital mortality of rate of 25 (21.6%). The median time of in hospital mortality and length of hospital stay after admission of the patients were 4.38 days and 9.21 days, respectively. The prominent suspected immediate cause for in hospital mortality was increased intracranial pressure in 17 (68.0%) followed by respiratory failure secondary to aspiration pneumonia in 11 (44.0%) patients. Brain edema (AHR: 6.27, 95% CI: 2.50-15.76), urine incontinence (AHR: 3.48, 95% CI: 1.48-8.17), National Institute of Health Stroke Scale (NIHSS) >13 during hospital arrival (AHR: 22.58, 95% CI: 2.95-172.56) and diagnosis of stroke clinically alone (AHR: 4.96, 95% CI: 1.96-12.54) were the independent predictors of time to in hospital mortality.
Conclusions: The mortality rate of stroke in this setup was comparable with other low- and middle-income countries (LMICs). There is an urgent need to establish well equipped and staffed stroke units in the country in addition to strengthen the already existing on. Furthermore, future work must be designed to identify the barriers to improve stroke outcomes and recovery.
Examination of preterm babies for ROP referred to an eye department from an urban and semi-urban neonatal intensive care unit: implications for practice.
Authors: Venkatesh Ramesh , Dave Prachi Abhishek , Gurav Prachi , Agarwal Manisha , Jajoo Mamta , Gupta Vidit 
Published: September 2019

Abstract
Background: To study and analyse the factors affecting the proportion of retinopathy of prematurity (ROP) distribution between the urban and semi-urban regions in North India.
Methods: Retrospective, observational, cross-sectional study. All babies referred for ROP examination by paediatricians or other general ophthalmologists between 2013 – 2016 were included in the study. Demographic, clinical and treatment related findings were recorded.
Results: Five hundred and fifty-eight (467: urban & 91: semi urban) babies were examined for ROP. The mean birth weight in the urban and semi-urban setting was 1348.6 ± 395.21 gm and 1703.77 ± 401.76 gm respectively. The mean gestational age was 30.99 ± 2.93 weeks and 30.73 ± 2.08 weeks in the urban and semi-urban cohorts respectively. The average time for first ophthalmic examination following birth was 23.82 ± 13.69 (range: 3-77) days in the urban and 101.16 ± 238.26 (range: 13- 330) days in the semi-urban setting. 94% of the babies completed all screening examination visits. Any ROP was identified in 11.6% and 33.0% of the urban and semi-urban cohorts respectively; Type 1 was detected in 7.5% of urban babies and 23.1% of semi-urban babies
Conclusion: Differences in the proportion of babies developing any ROP and Type 1 ROP between the semi-urban and urban groups is likely due to selection bias, as a high proportion of semi-urban babies did not attend for examination or failed to complete all the examinations necessary. This was particularly true for females. More needs to be done to increase access to regular, systematic screening of preterm babies within neonatal units.
Thermoelasticity, cation exchange, and deprotonation in Fe-rich holmquistite: Toward a crystal-chemical model for the high-temperature behavior of orthorhombic amphiboles
Authors: Oberti Roberta , Boiocchi Massimo , Zema Michele 
Published: September 2019

Abstract
The thermoelastic behavior of a crystal of Fe-rich holmquistite with crystal-chemical formula A(K0.01Na0.01)B(Li1.88Mg0.10Na0.02)C(Mg1.68Fe1.422+Mn0.022+Al1.88)TSi8.00O22W[(OH)1.97F0.03] was studied by single-crystal X-ray diffraction at temperatures up to 1023 K, where isothermal annealing in air for 160 h yielded the loss of 0.85 H apfu coupled with oxidation of M1Fe. A complex pattern of cation exchanges was deciphered by comparing structure refinements done before and after annealing. Li migration from the M4 to M3 site is responsible for nonlinearity of the c parameter around 600 K during the first annealing. Cooling of the partially deprotonated crystal to room temperature (RT) showed discontinuities in trends of the b and c parameters around 820–800 K, which cannot be ascribed to a phase transition and can be explained by a rearrangement of the structural units affecting the geometry of the M4 polyhedron. Such discontinuities have never been observed in amphiboles before and must be related to dimensional constraints deriving from the peculiar composition of this amphibole, which contains the smallest possible homovalent constituents, i.e., BLi, CAl, and TSi. The calculated thermo-elastic parameters are: Fe-rich holmquistite: αa = 1.36(2)×10–5; αb = 0.55(1)×10–5; αc = 1.5(1)×10–5 – 6.7(9)×10–9; αV = 3.5(3)×10–5 – 0.8(3)×10–8 (polynomial); 2.58(6)×10–5 (linear); partially deprotonated Fe-rich holmquistite: αa = 1.324(9)×10–5 (RT-1023 K); αb = 0.60(1)×10–5 (RT-773 K); αc = 0.68(2)×10–5 (RT-773 K); αV = 2.59(2)×10–5 (RT-773 K). Fe-rich holmquistite is much stiffer than all the previously studied orthorhombic Pnma and Pnmn amphiboles. The results of this work allow progress toward a general model that may explain how the amphibole structure responds to non-ambient conditions, and allows the release of water in diverse geological environments.
Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer
Authors: Oplawski Marcin , Dziobek Konrad , Zmarzły Nikola , Grabarek Beniamin O. , Kiełbasiński Robert , Kieszkowski Przemysław , Januszyk Piotr , Talkowski Karol , Schweizer Michał , Kras Piotr , Plewka Andrzej , Boroń Dariusz 
Published: September 2019

Background:Many experimental studies have demonstrated the importance of COX-2 in the tumor angiogenesis. Inducible iNOS is responsible for a high and stable level of nitric oxide and is expressed in response to pro-inflammatory factors.Objective:The aim of this study was to evaluate the expression of COX-2 and iNOS at the protein level and to assess their potential prognostic significance in patients with endometrial cancer.Methods:The study group consisted of 45 women with endometrial cancer divided according to the degree of histological differentiation i.e. G1, 17; G2, 15; G3, 13. The control group consisted of 15 women without neoplastic changes. The expression of studied proteins was determined immunohistochemically with specific polyclonal antibodies.Results:Analysis of the COX-2 expression showed that the optical density of the reaction product in G1 reached 186% in the control group, while the values in G2 and G3 reached 243% and 293%, respectively. In the case of iNOS, the optical density of the reaction product reached the following percentages in the control group: 147% in G1, 243% in G2, and 241% in G3.Conclusions:Our findings suggest that changes in the expression of COX-2 and iNOS may be potentially useful in predicting the progression of endometrial cancer and treatment effectiveness.
Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush
Authors: Zhang Mingyuan , Chen Lifei , Xu Fan , Jiang Li , Yan Wenya , Kunwar Bibhav , Tang Fen , Yang Ke , Shen Chaolan , Huang Hui , Lv Jian , Qin Chen , Wu Xiaonian , Zeng Siming , Li Min , Zhong Shan , Chen Qi 
Published: September 2019

Purpose:
Retinal ganglion cells (RGCs) apoptosis is a common characteristic
of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known
regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into
three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determine the
physiological relevance of PIDD in RGCs apoptosis in an optic nerve crush (ONC)
model.

Methods:
All animals were evenly randomized into four groups: sham-control group,
con-siRNA group, ONC group, and PIDD-siRNA group (ONC +PIDD-siRNA).
Expressions of PIDD, caspase-2, Brn3a and tBid in ONC model were analyzed by
Western blot and immunofluorescence. Mean densities of RGCs/mm2 were calculated
with Fluoro-Gold (FG). Moreover, we tested the effect of PIDD-siRNA on ONC-induced
RGCs apoptosis using TUNEL staining.

Results:
The level of full-length PIDD was weakly present and showed no significant
differences at any time points. PIDD-CC and PIDD-C were significantly up-regulated in
the retina at 3 days after ONC. Meanwhile, the expression of PIDD was significantly
increased in Brn3a (a marker of RGCs) positive cells, indicating that the localization of
PIDD appeared to be confined to RGCs. Furthermore, inhibition of PIDD prevented
RGCs apoptosis by inhibiting caspase-2 and tBid activation.

Conclusions:
Taken together, PIDD may play a crucial role in RGCs apoptosis after
ONC, and this process may be relevant to caspase-2 and tBid.
Klora Maruz Kalan A549 Hücre Hattında Çeşitli Antioksidanların Etkileri
Authors: SEZİGEN Sermet , SARPER Meral 
Published: September 2019

Amaç: Bu çalışmanın amacı; organizmada hipokloridin toksisitesini azaltan antioksidanlar olan berberin, N-Asetil sistein (NAC) ve askorbik asidin A549 hücre hattında hücre ölümü üzerine olan etkilerinin sodyum hipoklorit varlığında in vitro olarak tespit edilmesidir. Materyal-Metot: Adenokarsinomik insan alveolar bazal epitel hücre hattı olan A549’un %5 karbon dioksit ile 37° C sıcaklığa ayarlı inkübatörde kültürlenerek yayılması ve çoğalması sağlanmıştır. Berberin; NAC ve askorbik asidin etkilerinin incelenmesi amacıyla her bir etken maddenin üç dozu (50 µM, 100 µM ve 200 µM) sodyum hipoklorit (0.5 µM) ile muamele edilerek A549 hücrelerine uygulanmıştır. İnkübasyon sürecinde hücrelerin yayılması ve çoğalması; hücre sensörü tarafından algılanan empedansın elektronik okuması işlemini gerçekleştiren xCELLigence gerçek zamanlı hücre analiz sistemi kullanılarak eş zamanlı olarak izlenmiştir. Bulgular: xCELLigence kullanılarak yapılan gerçek zamanlı hücre analizinde özellikle yüksek konsantrasyonlardaki (500 µM ve 1.000 µM) sodyum hipokloridin A549 akciğer hücre hattında sitotoksik etkili olduğu tespit edilmiştir. Ayrıca berberin, NAC ve askorbik asidin sodyum hipoklorit varlığında A549 hücre hattı üzerinde doza bağımlı olarak hücre ölümünde artışa neden olduğu da gözlemlenmiştir.Sonuç: Sodyum hipokloridin A549 hücre hattı üzerine olan etkileri gerçek zamanlı olarak görüntülenerek reaktif oksijen türlerinin toksik dozlarda akciğerler üzerindeki etkileri gösterilmiştir. Klor maruziyeti sonrasında ortaya çıkan hipokloröz asidin oksidatif etkilerinin çeşitli antioksidanların kullanılmasıyla azalttığı bilinmektedir. Bununla birlikte çeşitli dozlarda uygulanan berberin, NAC ve askorbik asit gibi antioksidanların sodyum hipoklorit varlığında A549 hücre hattında toksik etkileri azaltmadığı sonucuna varılmıştır. Klor maruziyetinde tedavi yaklaşımlarının etkinliklerin karşılaştırıldığı deneysel çalışmalarda bu üç önemli antioksidanın neden olduğu etkilerin mekanizmalarının araştırılmasına ve hücresel hasarı azaltacak antioksidan cevabı sağlayabilecek etkin dozun tespit edilmesine ihtiyaç duyulmaktadır.
A CURA INTERIOR NO CATOLICISMO CARISMÁTICO: TECNOLOGIAS DE SI E PSICOLOGIZAÇÃO DA RELIGIÃO
Authors: SILVEIRA Emerson José Sena da 
Published: September 2019

O catolicismo carismático brasileiro, ao dialogar com as contemporâneas
transformações da identidade e da sociedade, produziu uma prática
chamada cura interior ou “cura das memórias e emoções”. Como experiência
religiosa, a cura interior expande-se em três segmentos: comunidades
carismáticas de vida e aliança, grupos e “flutuantes” (praticantes desvinculados
de grupos e comunidades). Sua prática é efetivada pelos “especialistas da cura”,
indivíduos que a exercem nos grupos e a aplicam às pessoas que demandam por
cura. No ritual da cura interior, ocorre a produção de uma tecnologia de
constituição do sujeito (tecnologia de si) em que a transferência e expansão
semântica de termos e procedimentos da psicologia junguiana (e outras), da
medicina e da tradição católica instituem um “fluxo intersubjetivo”, transversal
e simétrico, de um fazer-saber simultaneamente terapêutico e religioso. A cura
interior praticada pelos “especialistas da cura” torna-se um campo no qual
tendências contraditórias (busca de si e rendição ao (o)Outro) dialogam entre
si. Um diálogo que tem como palco a trajetória, a memória e as emoções dos
praticantes, apontando para novas formas de articulação entre as pequenas
narrativas biográficas (pontuais) e as grandes narrativas da religiosidade católica
(difusas e míticas)
CULTURA, IDENTIDADE E INCLUSÃO SOCIAL: O LUGAR DA RELIGIÃO PARA SEUS ATORES E INTERLOCUTORES
Authors: Burity Joanildo A. 
Published: September 2019

Este trabalho pretende contribuir para a compreensão dos problemas envolvidos
na concepção e implementação das políticas sociais em termos de como certas demandas e
atores sociais específicos ali se inserem, com destaque para as organizações religiosas. O
marco de referência para a análise proposta é o da constituição e ativação de uma esfera
pública híbrida, formada por atores governamentais e atores da sociedade civil, articulados
em redes que operam num plano local, nacional e transnacional. Explora-se a interface
entre religião e políticas sociais, a partir da avaliação de pessoas envolvidas em ambos os
campos, ligadas a agências governamentais ou organizações da sociedade civil, laicas e
religiosas. A ordem da exposição combina uma atenção para o contexto mais amplo em
que a referência religiosa se coloca e para a percepção de atores governamentais e nãogovernamentais sobre o lugar e o papel da referência religiosa neste campo.
O FENÔMENO RELIGIOSO: IDÉIAS SOBRE CONCEITO TIPOLÓGICO DE RELIGIÃO
Authors: Costa Maria Emília Corrêa da 
Published: September 2019

Este artigo discute as relações entre a religião e as políticas sociais. Inicialmente
aborda-se um conjunto de questões ligadas à liberdade religiosa como direito fundamental e a
laicidade como separação entre o Estado e as confissões religiosas. Depois se apresentam os
principais elementos do fenômeno religioso no campo jurídico, e a partir daí um conceito
tipológico de religião que reúne características consideradas qualitativamente típicas desse
fenômeno. Este conceito tipológico do termo religião ou de sua extensão no âmbito jurídico tem
a função de, ao possibilitar a reflexão, evitar o desvirtuamento ou a distorção do seu sentido,
que muitas vezes leva à discriminação e à interferência estatal indevida em matéria religiosa.
OS “SANTOS DA CRISE” E OS SISTEMAS DE EXPIAÇÃO COLETIVA DA INSEGURANÇA SOCIAL
Authors: Lopes José Rogério 
Published: September 2019

O texto analisa os modelos de criação e recriação dos códigos imagéticos
religiosos pelos quais sujeitos devotos populares expressam percepções contemporâneas
dos sentimentos vividos nas experiências de privações sociais. A abordagem recai na
difusão dos chamados “santos da crise”, sua diversidade de figurações, exteriorizadas
desde mediações diversas que configuram as redes devocionais a esses santos,
manipuladas na esfera pública. As propriedades reconhecidas em tais santos são
intercambiáveis com as de outros, gerando uma “fabricação da santidade” marcada pela
“porosidade” com as experiências de privações sociais, que pode ser percebida nas
figurações desses santos, em diversas situações sociais, reais ou virtuais. Busca-se, com
essa análise, evidenciar a necessidade de relacionar as investigações sobre essas novas
devoções com as estratégias contemporâneas de reprodução da vida popular, na forma
de sistemas de expiação idealizados em uma condição comum sobre a qual o sentimento
de insegurança se projeta, nas condições de degradação, para constituir novos suportes
de realização pessoal e coletiva.
The Usefulness of Accounting Information Resulting from Standard-Setting Compromises: The Pension Accounting Case
Authors: Cussatt Marc , Pollard Troy J. , Stone Mary S. 
Published: September 2019

SYNOPSIS
Most U.S. employers sponsoring defined benefit pension plans use an accounting model that balances managers' preference for income smoothing with the FASB's belief in fair value measurement. This model, which we refer to as the deferral/reclassification model, requires current period gains/losses and costs of plan amendments to be closed to accumulated other comprehensive income (AOCI) and reclassified to earnings in subsequent periods (RECLASS). The usefulness of information produced by this model is questioned, especially RECLASS adjustments, which affect earnings in periods subsequent to the economic events that engendered them. This study examines the usefulness of information produced by the deferral/reclassification model. We find that AOCI and RECLASS amounts demonstrate predictive ability and exhibit value relevance. Additional analyses compare the usefulness of information produced by the deferral/reclassification and fair value models. Our results suggest that although the deferral/reclassification model is not conceptually defensible, the information it produces appears to be useful.
JEL Classifications: M40; M41.