bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Dysfunction and Reproductive Concerns in Young Men Diagnosed With Testicular Cancer: An Observational Study
Authors: Ljungman L. , Eriksson L.E. , Flynn K.E. , Gorman J.R. , Ståhl O. , Weinfurt K. , Wiklander M. , Lampic C. , Wettergren L. 
Published: June 2019

AbstractIntroductionThe survival rates for testicular cancer are excellent; still, there is a lack of knowledge regarding important survivorship issues, such as sexual dysfunction and reproductive concerns.AimThe aim of this study was to investigate the prevalence and predictors of sexual dysfunction and reproductive concerns and the potential association between these issues in young men ∼2 years after a diagnosis of testicular cancer.MethodsData were collected from 111 men (response rate = 50%) diagnosed with testicular cancer at age 16–39. Patients were identified via the Swedish National Quality Registry for Testicular Cancer and approached with a survey, including standardized measures of sexual function, reproductive concerns, body image, and health-related quality of life. The survey was sent to participants approximately 2 years after their cancer diagnosis. Clinical variables were collected from the registry. Predictors were identified by multivariable linear regression analyses.Main Outcome MeasuresThe main outcomes were sexual function, assessed with the Patient-Reported Outcomes Measurement Information System Sexual Function and Satisfaction measure version 2.0, and reproductive concerns, assessed with the Reproductive Concerns After Cancer scale.ResultsSexual dysfunction was reported by 26% of men, and a high level of reproductive concerns was reported by 28%. Lower satisfaction with sex life was associated with older age (β = −0.41), negative body image (β = −0.42), not having a partner (β = 4.8), and dissatisfaction with sex life before cancer (β = 8.31). Negative body image was associated with reproductive concerns in the dimensions of fertility potential (β = 0.06), partner disclosure (β = 0.08), and child’s health (β = 0.07), whereas having had fertility preservation predicted higher levels of concerns with regard to personal health (β = 0.52) and achieving pregnancy (β = 0.53). Clinical variables did not predict either sexual function or reproductive concerns.Clinical ImplicationsOur results show that the majority of young men diagnosed with testicular cancer do not report sexual dysfunction or reproductive concerns 2 years after diagnosis. A sizeable minority, however, does report dysfunction or reproductive concerns, which should be recognized in the follow-up care of this population.Strengths & LimitationsA strength of the study is the use of high-quality registry data and validated instruments. The lack of Swedish norms for sexual function and reproductive concerns is a possible limitation.ConclusionA subgroup of young men treated for testicular cancer report sexual dysfunction or reproductive concerns approximately 2 years after diagnosis. Factors associated with these issues seem to mainly be psychological, rather than medical, nature.
Salvage pulmonary thromboembolectomy for massive pulmonary embolism in a child presented with syncope and subsequent cardiac arrest
Authors: Ak Koray , Birkan Yasar , Akalın Figen , Günay Deniz 
Published: June 2019

AbstractPulmonary embolism is frequently under-recognised in children and, therefore, a high index of suspicion should be exerted on patients with exertional dyspnoea, presyncope/syncope and unexplained cardiopulmonary arrest. We discuss a 10-year-old previously healthy girl who presented with syncope and subsequent cardiac arrest related to massive pulmonary embolism and was salvaged successfully by emergent pulmonary embolectomy.
Constrictive pericarditis following necrotising pneumococcal pneumonia in an immunocompetent child
Authors: Yubbu Putri , Kaur Jasvinder , Jamaluddin Johan Aref 
Published: June 2019

AbstractPurulent pericarditis leading to constrictive pericarditis is a rare but serious complication following invasive pneumococcal infection. Early recognition of this complication is crucial to prevent mortality. Here, we report a previously healthy child who developed constrictive pericarditis due to purulent pericarditis following necrotising pneumococcal pneumonia, which is not common in this current antibiotic and pneumococcal vaccine era. The child was successfully treated with pericardiectomy.
Access to primary health care among women: the role of Ghana’s community-based health planning and services policy
Authors: Braimah Joseph Asumah , Sano Yujiro , Atuoye Kilian Nasung , Luginaah Isaac 
Published: June 2019

AbstractBackground:Ghana in 1999 adopted the Community-based Health Planning and Service (CHPS) policy to enhance access to primary health care (PHC) service. After two decades of implementation, there remains a considerable proportion of the country’s population, especially women who lack access to basic health care services.Aim:The aim of this paper is to understand the contribution of Ghana’s CHPS policy to women’s access to PHC services in the Upper West Region (UWR) of Ghana.Methods:A logistic regression technique was employed to analyse cross-sectional data collected among women (805) from the UWR.Findings:We found that women who resided in CHPS zones (OR = 1.612;P ≤0.01) were more likely to have access to health care compared with their counterparts who resided in non-CHPS zones. Also, rural-urban residence, distance to health facility, household wealth status and marital status predicted access to health care among women in the region. Our findings underscore the need to expand the CHPS policy to cover many areas in the country, especially rural communities and other deprived localities in urban settings.
Field evaluation of preemergence and postemergence herbicides for control of protoporphyrinogen oxidase-resistant Palmer amaranth (Amaranthus palmeri S. Watson)
Authors: Houston Michael M , Norsworthy Jason K , Barber Tom , Brabham Chad 
Published: June 2019

AbstractPalmer amaranth accessions resistant to protoporphyrinogen oxidase (PPO), 5-enolpyruvyl-shikimate-3-phosphate synthase, and acetolactate synthase (ALS)-inhibitor herbicides are widespread in the Midsouth, making control difficult. Field experiments were conducted in Marion and Crawfordsville, AR, in 2016 and 2017 to assess PRE and POST herbicides labeled for use in corn, cotton, or soybean for control of multiresistant Palmer amaranth. Accessions at both locations were resistant to glyphosate and ALS inhibitors and segregating for both the R128 and ΔG210 PPO resistance mechanisms. Of the 15 herbicide treatments tested, only atrazine (1,120 g ai ha−1), pyroxasulfone (149 g ha−1), and flumioxazin (144 g ha−1) provided 85% or greater Palmer amaranth control 14 days after treatment (DAT). Visible control ratings at 35 DAT declined sharply, with no treatment providing more than 84% control, suggesting POST applications should be made no later than 28 DAT. Glufosinate (594 and 818 g ha−1), dicamba (560 g ae ha−1), 2,4-D plus glyphosate (784 g ae ha−1 plus 834 g ae ha−1), and paraquat (700 g ha−1) applied POST to 7- to 10-cm plants reduced Palmer amaranth density 83% or more 14 DAT. Both glyphosate (1,266 g ha−1) and pyrithiobac sodium (73 g ha−1) provided less than 7% Palmer amaranth control. Although flumioxazin alone at a labeled rate controlled Palmer amaranth 82% in the PRE experiment, PPO inhibitors by themselves applied POST provided no more than 37% control at 14 DAT. Effective foliar herbicides applied POST, including residual herbicides, should be made when Palmer amaranth are less than 10-cm tall for optimal control of these multiresistant Palmer amaranth accessions.
Theoretical Predictability Limits of Spatially Anisotropic Multifractal Processes: Implications for Weather Prediction
Authors: Ramanathan Arun , Satyanarayana A.N.V. , Mandal M. 
Published: June 2019

AbstractA correlation spectrum‐based approach is used to express the theoretical predictability limits of multifractal processes as an analytical function of their anisotropy parameters. This spatially anisotropic power law function is then used to investigate the general impact of anisotropy on the predictability of atmospheric fields in the weather regime. The investigation reveals that (i) vertical stratification of a field increases and decreases its super and subsphero‐scale predictability limits, respectively; (ii) trivial horizontal anisotropy slightly improves predictability at all scales; and (iii) horizontal anisotropy together with vertical stratification significantly enhances its predictability over almost the entire scale range. Applying these general results to the case of horizontal wind fields suggests that the interplay between spatial‐anisotropy and atmospheric predictability could account for improvements in forecast skill, commonly observed during the occurrence of rotating thunderstorms and breaks in the Indian summer monsoon.
Late Jurassic‐Early Cretaceous Deformation in the Western Yanshan Fold‐Thrust Belt: Insights From Syntectonic Sedimentation in the Chicheng Basin, North China
Authors: Lin Chengfa , Liu Shaofeng , Shi Xiaofei , Zhuang Qitian 
Published: June 2019

AbstractThe Yanshan fold‐thrust belt is a significant intraplate deformation belt along the northern margin of North China Craton and records multiple phases of deformation during the Mesozoic. However, the specific tectonic evolution of the Yanshan belt during the Mesozoic has long been debated. In particular, many arguments exit regarding whether a contractional or extensional context dominated the Yanshan belt in the Late Jurassic‐Early Cretaceous. One reason for this argument is the poor understanding of the tectono‐sedimentary relationship preserved in the sedimentary records. A lack of evidence of syntectonic sediments makes it more difficult to reconstruct this relationship. The Chicheng basin in the western Yanshan belt contains complete Upper Jurassic‐Lower Cretaceous succession and is bounded by marginal faults. New regional geological mapping, detailed sedimentary facies analysis, and recognition of two growth strata packages help reconstruct the tectono‐sedimentary relationship in the Chicheng basin. Additionally, zircon U‐Pb dating provides constraints on the timing of the deformation. Our results suggest that the dynamic sediment dispersal system in the Chicheng basin during the Late Jurassic‐Early Cretaceous were controlled by two phases of thrusting, including the activities of the Shangyi‐Pingquan fault during 162–147 Ma, and the Fengning‐Longhua fault during 140–135 Ma. Therefore, we propose that the western Yanshan belt was in a contractional context during the Late Jurassic‐Early Cretaceous. Our findings indicate that the tectonic setting of the Yanshan belt experienced a prominent transition from E‐W trending structures to NE‐SW trending structures and that this transition was probably related to subduction of the Paleo‐Pacific plate beneath the East Asian continent.
On Deriving Gravity Wave Characteristics in the Daytime Upper Atmosphere Using Radio Technique
Authors: Mandal Subir , Pallamraju Duggirala , Karan Deepak K. , Phadke Kedar A. , Singh Ravindra P. , Suryawanshi Pradip 
Published: June 2019

AbstractThe importance of neutral wave dynamics in the understanding of the upper atmospheric processes is well known. Conventionally, optical methods are used to derive information on the neutral wave dynamics by obtaining gravity wave (GW) characteristics. Optical measurement techniques use airglow emissions as tracers to obtain such information that correspond to altitudes from where the emissions emanate. However, in this paper, we describe a method using radio wave measurement technique (digisonde) to obtain information on the neutral GW behavior. It involves monitoring of variations in the heights of isoelectron densities as a function of time, and their phase shifts, if any, to derive vertical propagation speeds and scale sizes of GWs. The daytime values of GW time periods, vertical phase speeds, and vertical scale sizes obtained for the duration of 16–21 May 2015 are in the range of 1.47 ± 0.05 to 2.64 ± 0.07 hr, 30.06 ± 4.35 to 45.69 ± 11.84 m/s, and 183.21 ± 39.23 to 393.07 ± 66.38 km, respectively. Further, we have used the GW dispersion relation to make a first‐order estimation of the horizontal scale sizes. This method of deriving neutral GW characteristics through radio measurement technique is effective for the daytime conditions and opens up new possibilities of investigations of the wave dynamical behavior in the upper atmosphere during all weather conditions.
Highly Relativistic Electron Flux Enhancement During the Weak Geomagnetic Storm of April–May 2017
Authors: Katsavrias Ch. , Sandberg I. , Li W. , Podladchikova O. , Daglis I.A. , Papadimitriou C. , Tsironis C. , Aminalragia‐Giamini S. 
Published: June 2019

AbstractWe report observations of energetic electron flux and phase space density to show that a relatively weak magnetic storm with Sym‐Hmin≈−50 nT, resulted in a relativistic and ultrarelativistic electron enhancement of two orders of magnitude similar to the St. Patrick's event of 2015, an extreme storm with Sym‐Hmin≈−235 nT. This enhancement appeared at energies up to ≈10 MeV, lasted for at least 24 days, and was not recorded in geosynchronous orbit where most space weather alert data are collected. By combined analysis of phase space density radial profiles and Fokker‐Planck simulation, we show that the enhancement of relativistic and ultrarelativistic electrons is caused by different mechanisms: first, chorus waves during the intense substorm injections of 21–25 April accelerate the seed electron population to relativistic energies and redistribute them while inward diffusion driven by Pc5 Ultra‐Low Frequency (ULF) waves further accelerates them to ultrarelativistic energies.
Diagnosing Observed Stratospheric Water Vapor Relationships to the Cold Point Tropical Tropopause
Authors: Randel William , Park Mijeong 
Published: June 2019

AbstractDehydration at the tropical cold point tropopause primarily controls the entry value of water vapor to the stratosphere, with additional (uncertain) contributions from subtropical monsoonal circulations and extreme deep convection. Here we quantify the links of observed stratospheric water vapor with near‐equatorial cold point temperature (TCP), based on interannual variations of monthly zonal averages over the period 1993–2017. Water vapor observations are from combined Halogen Occultation Experiment and Aura Microwave Limb Sounder satellite measurements, and cold point temperatures are from high quality radiosondes and GPS satellite data. Interannual water vapor anomalies are highly correlated with TCP, and coherent patterns can be traced in space and time away from the tropical tropopause to quantify transport in the Brewer‐Dobson circulation, including diagnosing seasonal changes in circulation. Lagged regressions with TCP are used to reconstruct water vapor variations directly tied to the cold point, and these reconstructions account for a majority of the observed interannual water vapor variability in the lower to middle stratosphere over most of the globe. Small systematic differences from observed water vapor can identify processes not tied to zonal average TCP, and/or possible uncertainties in the satellite measurements.
A Randomized Trait Community Clustering approach to unveil consistent environmental thresholds in community assembly
Authors: Triadó-Margarit Xavier , Capitán José A , Menéndez-Serra Mateu , Ortiz-Álvarez Rüdiger , Ontiveros Vicente J , Casamayor Emilio O , Alonso David 
Published: June 2019

Abstract
Similarities and differences of phenotypes within local co-occurring species hold the key to inferring the contribution of stochastic or deterministic processes in community assembly. Developing both phylogenetic-based and trait-based quantitative methods to unravel these processes is a major aim in community ecology. We developed a trait-based approach that: (i) assesses if a community trait clustering pattern is related to increasing environmental constraints along a gradient; and (ii) determines quantitative thresholds for an environmental variable along a gradient to interpret changes in prevailing community assembly drivers. We used a regional set of natural shallow saline ponds covering a wide salinity gradient (0.1–40% w/v). We identify a consistent discrete salinity threshold (ca. 5%) for microbial community assembly drivers. Above 5% salinity a strong environmental filtering prevailed as an assembly force, whereas a combination of biotic and abiotic factors dominated at lower salinities. This method provides a conceptual approach to identify consistent environmental thresholds in community assembly and enables quantitative predictions for the ecological impact of environmental changes.
In situ transformation of ethoxylate and glycol surfactants by shale-colonizing microorganisms during hydraulic fracturing
Authors: Evans Morgan V , Getzinger Gordon , Luek Jenna L , Hanson Andrea J , McLaughlin Molly C , Blotevogel Jens , Welch Susan A , Nicora Carrie D , Purvine Samuel O , Xu Chengdong , Cole David R , Darrah Thomas H , Hoyt David W , Metz Thomas O , Lee Ferguson P , Lipton Mary S , Wilkins Michael J , Mouser Paula J 
Published: June 2019

Abstract
In the last decade, extensive application of hydraulic fracturing technologies to unconventional low-permeability hydrocarbon-rich formations has significantly increased natural-gas production in the United States and abroad. The injection of surface-sourced fluids to generate fractures in the deep subsurface introduces microbial cells and substrates to low-permeability rock. A subset of injected organic additives has been investigated for their ability to support biological growth in shale microbial community members; however, to date, little is known on how complex xenobiotic organic compounds undergo biotransformations in this deep rock ecosystem. Here, high-resolution chemical, metagenomic, and proteomic analyses reveal that widely-used surfactants are degraded by the shale-associated taxa Halanaerobium, both in situ and under laboratory conditions. These halotolerant bacteria exhibit surfactant substrate specificities, preferring polymeric propoxylated glycols (PPGs) and longer alkyl polyethoxylates (AEOs) over polyethylene glycols (PEGs) and shorter AEOs. Enzymatic transformation occurs through repeated terminal-end polyglycol chain shortening during co-metabolic growth through the methylglyoxal bypass. This work provides the first evidence that shale microorganisms can transform xenobiotic surfactants in fracture fluid formulations, potentially affecting the efficiency of hydrocarbon recovery, and demonstrating an important association between injected substrates and microbial growth in an engineered subsurface ecosystem.
A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care
Authors: Halvorsen Cecilia Pegelow , Olson Linus , Araújo Ana Catarina , Karlsson Mathias , Nguyễn Trang Thị , Khu Dung T. K. , Le Ha T. T. , Nguyễn Hoa T. B. , Winbladh Birger , Russom Aman 
Published: June 2019

AbstractThere is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson’s correlation test was 0.91 (p < 0.01) and the R2 = 0.83 between the two methods. The mean LDH (±SD) for the reference method vs. the POC-LDH was 551 (±280) U/L and 552 (±249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.
From observing to predicting single-cell structure and function with high-throughput/high-content microscopy
Authors: Chessel Anatole , Carazo Salas Rafael E. 
Published: June 2019

Abstract
In the past 15 years, cell-based microscopy has evolved its focus from observing cell function to aiming to predict it. In particular—powered by breakthroughs in computer vision, large-scale image analysis and machine learning—high-throughput and high-content microscopy imaging have enabled to uniquely harness single-cell information to systematically discover and annotate genes and regulatory pathways, uncover systems-level interactions and causal links between cellular processes, and begin to clarify and predict causal cellular behaviour and decision making. Here we review these developments, discuss emerging trends in the field, and describe how single-cell ‘omics and single-cell microscopy are imminently in an intersecting trajectory. The marriage of these two fields will make possible an unprecedented understanding of cell and tissue behaviour and function.
Gaia kinematics reveal a complex lopsided and twisted Galactic disc warp
Authors: Romero-Gómez M. , Mateu C. , Aguilar L. , Figueras F. , Castro-Ginard A. 
Published: June 2019

Context. There are few warp kinematic models of the Galaxy able to characterise both structure and kinematics, since these require high accuracy at large distances. These models are necessary to shed light on the lopsidedness of the warp and the twisting of the line-of-nodes of the stellar warp already seen in gas and dust.
Aims. We use the vertical information coming from the Gaia Data Release 2 astrometric data up to G = 20 mag to characterise the structure of the Galactic warp, the related vertical motions, and the dependency of Galactic warp on age.
Methods. We analyse two populations up to Galactocentric distances of 16 kpc: a young bright sample mainly formed by OB stars and an older one of red giant branch (RGB) stars. We use two methods (the pole count maps of great circle bands and Galactic longitude – proper motion in latitude lines) based on the Gaia observables, together with 2D projections of the positions and proper motions in the Galactic plane.
Results. This work confirms the age dependency of the Galactic warp, both in position and kinematics, the height of the Galactic warp being of the order of 0.2 kpc for the OB sample and 1.0 kpc for the RGB at a Galactocentric distance of 14 kpc. Both methods find that the onset radius of the warp is 12 ∼ 13 kpc for the OB sample and 10 ∼ 11 kpc for the RGB. From the RGB sample, we find from Galactocentric distances larger than 10 kpc that the line-of-nodes twists away from the Sun-anticentre line towards Galactic azimuths ≈180−200° increasing with radius, though possibly influenced by extinction. Also, the RGB sample reveals a slightly lopsided stellar warp with ≈250 pc difference between the up and down sides. The line of maximum of proper motions in latitude is systematically offset from the line-of-nodes estimated from the spatial data, which our warp models predict as a kinematic signature of lopsidedness. We also show a prominent wave-like pattern of a bending mode different in the OB and RGB samples. Both positions and kinematics also reveal substructures that might not be related to the large-scale Galactic warp or to the bending mode.
Conclusions. Gaia Data Release 2 data reveals a high degree of complexity in terms of both position and velocity that triggers the need for complex kinematic models flexible enough to combine both wave-like patterns and an S-shaped lopsided warp.