bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6
Authors: Finicle Brendan T. , Ramirez Manuel U. , Liu Gang , Selwan Elizabeth M. , McCracken Alison N. , Yu Jingwen , Joo Yoosun , Nguyen Jannett , Ou Kevin , Roy Saurabh Ghosh , Mendoza Victor D. , Corrales Dania Virginia , Edinger Aimee L. 
Published: May 2018

ABSTRACT
Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF6. Consistent with reported roles for ARF6 in maintaining the tubular recycling endosome, MICAL-L1-positive tubules were lost from sphingolipid-treated cells. We propose that ARF6 inactivation may occur downstream of PP2A activation since: (1) sphingolipids that fail to activate PP2A did not reduce ARF6-GTP levels; (2) a structurally unrelated PP2A activator disrupted tubular recycling endosome morphology and transporter localization; and (3) overexpression of a phosphomimetic mutant of the ARF6 GEF GRP1 prevented nutrient transporter loss. ARF6 inhibition alone was not toxic; however, the ARF6 inhibitors SecinH3 and NAV2729 dramatically enhanced the killing of cancer cells by SH-BC-893 without increasing toxicity to peripheral blood mononuclear cells, suggesting that ARF6 inactivation contributes to the anti-neoplastic actions of sphingolipids. Taken together, these studies provide mechanistic insight into how ceramide and sphingolipid-like molecules limit nutrient access and suppress tumor cell growth and survival.
Surviving in Global Online Labor Markets for IT Services: A Geo-Economic Analysis
Authors: Kanat Irfan , Hong Yili , Raghu T. S. 
Published: May 2018

Global online labor markets (OLMs) lower the barriers to entry and enable global competition for information technology (IT) services from providers around the world. Although the prior OLM literature predominantly found systematic advantages for IT service providers from developed countries because of their higher perceived quality, the reality is that most service providers in OLM are from developing countries. This phenomenon requires a robust analysis of how OLMs are evolving. In this study, we conduct a geo-economic analysis on IT service providers’ survival utilizing a unique longitudinal panel data set from an OLM, which comprises 40,874 IT service providers from different countries over a period of more than four years (2006 to 2010). Based on results from Survival models and a series of robustness checks, we were able to decipher how geo-economic factors (specifically the country development level) and reputation interact to determine service providers’ survival. Our findings provide a different perspective from the prior literature on OLM by showing a systematic advantage for IT service providers from developing countries in terms of survival, especially when providers from developing countries were able to signal their individual quality through reputation. We explain and discuss the mechanisms underlying these effects, and highlight implications for OLMs for IT services. The online appendix is available at https://doi.org/10.1287/isre.2017.0751 .
Index Membership and Small Firm Financing
Authors: Cao Charles , Gustafson Matthew , Velthuis Raisa 
Published: May 2018

This paper investigates the extent to which index membership affects small firm financing. Using a regression discontinuity specification around the lower cutoff of the Russell 2000 small-cap index, we find that index membership causes small firms to transition away from bank financing in favor of seasoned equity offerings. These effects are concentrated in the year following Russell 2000 additions and do not reverse immediately upon deletions. Liquidity, the elasticity of demand for equity, and analyst coverage also significantly increase following Russell 2000 additions but do not significantly decrease following deletions. Finally, firms added to the Russell 2000 obtain lower spreads and have fewer covenants on the bank loans that they do initiate. Our findings are consistent with index membership mitigating the financing frictions of small firms by improving their information environment through increased investor awareness. This paper was accepted by Amit Seru, finance.
DA HISTÓRIA NEGADA A LUTA POR UMA VISIBILIDADE IGUALADA
Authors: Silva Jeusamir Alves 
Published: May 2018

ResumoO principal objetivo deste trabalho é dar visibilidade ao povo banto, com base na Lei. 10.6392003/PR, incluindo a sua história e cultura nas grades curriculares do ensino brasileiro, usando como fio condutor a sua religião. Escolheu-se como objeto de estudo terreiros bantos de diferentes pontos do Brasil. A justificativa é que apesar dos bantos terem sido os primeiros escravos aqui introduzidos, e espalhados por todo território brasileiro, (do século XVI ao XIX), praticamente, nada, sabe-se sobre o seu papel na formação do Brasil e na construção da nossa língua. Utilizou-se a pesquisa de campo baseada em visitas a terreiros, bem como, entrevistas com sacerdotes, devidamente autorizadas pelos mesmos, sendo eles: o Tata Katuwanjesi (Walmir Damasceno), presidente do ILABANTU – Instituto Latino Americano de Tradições Afro-Bantu, em Itapecerica da Serra-SP. Tata Kassulupongo (Moisés Queirós), dirigente da Casa do Benguê ria Lembaranganga, em Extremóz – RN, Mam’etu Nangakovi (Risoleta de Oliveira), do Terreiro de Matamba, emde São João de Meriti - RJ , entre outros.. A revisão bibliográfica ficou por conta dos referenciais teóricos ofertados por autores como: Adolfo (2010), Angelo (2013), Freire (2006), Lopes (2012), Mott, (1997), Prandi (1991), Redinha (1985), Scisínio (1997) entre outros. Confirmou-se então, a importância desse povo, na construção da nossa língua e na formação da nação brasileira. Com os resultados obtidos e o interesse acadêmico, espera-se alcançar em breve, a inclusão e visibilidade desejadas, bem como ter, também, registrado nos anais da história o Candomblé de Tradição Banto, como religião afro-brasileira.
Trajetória de uma trabalhadora humanitária no Oriente Médio e África | The journey of a humanitarian aid worker in the Middle East and Africa
Authors: Quintiliano Ungierowicz Nathalia Bezerra 
Published: May 2018

Nathalia conta sua história pessoal sobre como deixou sua carreira como especialista em comércio e logística internacional no ramo industrial para se tornar uma representante das Nações Unidas em resposta às maiores crises humanitárias no Oriente Medio da atualidade. Neste artigo, ela fala de sua trajetória profissional, a influência de sua família nesta decisão, e o que vem aprendendo e observando desde que saiu do Rio de Janeiro para morar na fronteira da Síria, em 2014. Nathalia também da dicas para aqueles que sonham em seguir a mesma profissão.ABSTRACTNathalia shares her personal story of how she left a job in international trade and logistics to become a UN officer responding to the biggest humanitarian crisis in the Middle East. In this paper, she shares her professional journey, discusses the influence of her family, and describes what she has learned and observed since leaving Rio de Janeiro in 2014 to live at the Syrian border. Nathalia also gives some advice to those who dream of following the same career path.Palavras-chave: ONU; Trabalho Humanitário; Oriente Medio; Síria.Keywords: UN; Humanitarian Work; Middle East; Syria. Recebido em 23 de Maio de 2018 | Received May 23, 2018DOI
Association between inherited thrombophilia in pregnancy and micronucleus frequency in peripheral blood lymphocytes
Authors: Šošić GM , Jović N , Rakić B , Dimitrijević A , Varjačić M 
Published: May 2018

Abstract
The aim of this study was to determine possible predictors of an increased frequency of micronucleus (MN) and the impact of thrombophilia on the chromosomal instability in peripheral blood lymphocytes (PBL) of pregnant women in their first trimester. This study was designed as a case-control study on 74 pregnant women. It was performed in the gestational age of 11 to 14 weeks, when blood samples were collected and incubated for 72 hours. The individual MN frequency in PBL was measured by cytokinesis-block micronucleus (CBMN) assay. Women were grouped in control group [≤4 MN/1000 binucleated (BN) cells] and case group (>4 MN/1000 BN cells). Potential mutagenic effects of exogenous/endogenous factors in pregnant women were analyzed. By analyzing the given results, it can be concluded that pregnant women with thrombophilia have 26.69-times more chance of having a frequency of >4 MN/1000 BN than pregnant women with no thrombophilia. Our research was primarily aimed at showing that the presence of thrombophilia was a statistically important predictor of an increased MN frequency in pregnant women and it can predict about one-third of the total variance in MN frequency in the studied population.
The mitochondrial COI/tRNASER(UCN) G7444A mutation may be associated with hearing impairment in a Han Chinese family
Authors: Ding Y , Xia B-H , Teng Y-S , Zhuo G-C , Leng J-H 
Published: May 2018

Abstract
Variations in mitochondrial genome have been found to be associated with hearing loss. Of these, the mitochondrial 12S rRNA and tRNASer(UCN) are the hot-spots for pathogenic variants associated with deafness. To understand the putative role of mitochondrial DNA (mtDNA) variants in hearing loss, we recently screened the variants in mitochondrial genomes in patients with deafness from the Hangzhou area of Zhejiang Province, People’s Republic of China (PRC). In this study, we describe a maternally-inherited Han Chinese family with high penetrance of hearing loss, notably, the penetrance of hearing loss in this family were 80.0 and 40.0%, when the aminoglycoside was included or excluded. Three matrilineal relatives in this pedigree exhibited different levels of hearing loss with different age at onset. In addition, sequence analysis of the complete mitochondrial genome showed the presence of the well-known C1494T pathogenic variant in the 12S rRNA gene and the G7444A pathogenic variant in the COI/ tRNASer(UCN). The C1494T anomaly had been reported to be a pathogenic mutation associated with aminoglycoside-induced and nonsyndromic hearing loss (AINHL), while the G7444A was considered as a secondary mutation associated with deafness. However, the lack of functional variants in GJB2 and TRMU genes suggested that nuclear modified genes may not play important roles in deafness expression. Thus, the combination of G7444A and C1494T pathogenic variants in the mitochondrial genome may account for the high penetrance of hearing loss in this Chinese family.
Molecular characterization of iranian patients with inherited coagulation factor VII deficiency
Authors: Shahbazi S , Mahdian R , Karimi K , Mashayekhi A 
Published: May 2018

Abstract
Coagulation factor VII (FVII) is a key enzyme of the extrinsic coagulation cascade that is predominantly produced by hepatocytes. The F7 gene mutations cause FVII deficiency with considerable molecular and phenotypic heterogeneity. We characterized the molecular alterations of the F7 gene and their corresponding mRNA transcripts in Iranian patients from eight unrelated families. The mutations were detected by polymerase chain reaction (PCR)-sequencing of all F7 gene exons, their flanking intronic sequences, as well as their corresponding cDNA fragments. Homozygous P303T, C91S and R304Q mutations were detected in patient 2, patient 5, and patient 6, respectively. Patient 7 was a compound heterozygote for S282R and H348R and patient 8 was a compound heterozygote for R304Q and IVS7+7A>G mutations. Furthermore, our investigation revealed three heterozygous individuals, patient 1 and patient 3 with the A244V mutation who were symptomatic and patient 4 with V(–39)I mutation who was also asymptomatic. The F7 mRNA expression analysis revealed that, except the transcript of V(–39)I, other mutation-harboring transcripts were expressed at detectable levels. In conclusion, this report reinforces the genetic and phenotypic heterogeneity of FVII deficiency. The findings of the mRNA study implied that decreased FVII protein activity subsequent to missense mutations does not completely reflect the degradation of mutation-harboring mRNA.
Intrapersonal conflicts of bloggers: psychological perspective
Authors: Secheiko Olena 
Published: May 2018

Abstract

Aim.
The aim of the study was to establish depth and substantive characteristics of intrapersonal conflicts of bloggers. Internal conflicts were analyzed at the levels of individual typological characteristics, self-conception, and value orientation of personality.

Research methodology.

The study was based on the method of content analysis and psychodiagnostic tests. 100 respondents (50 respondents who have blogs and 50 respondents who do not have blogs) were examined with Sobczyk’s individual typological questionnaire, Stephenson’s Q sorting, Budassi’s scale of self-assessment, Leary’s interpersonal diagnosis of personality, Fantalova’s value / accessibility correlation in different life spheres. Mann-Whitney test and Spearman’s rank correlation coefficient were applied for statistical data processing.

Research results.

The results of the survey support the hypothesis regarding the special character of the intra-personal conflicts of bloggers in comparison with those people who do not have blogs and use the Internet less often. In fact, conflicts between real self and virtual self are characteristic of bloggers. Most of the tension is the result of contradiction of ideas about their personal social and communicative competence and the opposition of coping strategies “acceptance of struggle – avoidance of struggle”.

Conclusions.

There are different views on how the Internet influences psychological wellbeing. Social networks allow bloggers to present themselves in a certain desired light, to create some image, to stress their unique features, to attract attention to those character properties which are not manifested in real life as desired.
The role of long term care centers in the Polish system of mental health care
Authors: Siejko Krzysztof , Tylec Aneta , Dubas-Ślemp Halina , Książek Piotr , Drop Bartłomiej , Kochański Artur , Kucharska Katarzyna 
Published: May 2018

Abstract

Objective:
The aim of this work is to review the role of mental health care center and treatment center specialized in psychiatry in the Polish system of mental health care as a whole.

Review:
For many years in Poland, the process of transformation of psychiatric care model from the institutional (inpatient setting, most expensive) to community care model (personalized, much cheaper), has been taking place. The effective - coordinated system of community care should significantly improve cooperation in the treatment, while the community forms of health care should ensure full availability, complexity, and continuity of care provision. In many cases, the community support is inadequate and cannot provide patient with care at his home environment. For mentally ill, there may be a need for the use of the long term health care centers specialized in psychiatry.

Conclusions:
A long term mental health care center specialised in mental health plays an important role in long-term care for the mentally ill. As far as a mental health service user’s perspective is concerned, the continuity of care and treatment in the long term health care center (as a health care unit) appears to be more useful and satisfying compared to a residential home for people with chronic mental illnesses. There is a need for broad discussion on the special place of the long term health care center specialized in psychiatry in the present Polish system of mental health care and on the improving of care pathways between inpatient-, day care-and, community care package.
Successful outcome of a preterm infant with severe oligohydramnios and suspected pulmonary hypoplasia following premature rupture of membranes (PPROM) at 18 weeks’ gestation
Authors: Pegu Satyaranjan , Murthy Poornima 
Published: May 2018

Abstract
Premature rupture of membranes (PPROM) can occur in up to 3–4.5% of pregnancies and lead to complications in the mother and fetus. Maternal chorioamnionitis is the most common complication and may even lead to sepsis. In the fetus, depending upon the time of PPROM causing oligohydramnios, the effect on the lung growth is variable leading to varying degrees of pulmonary hypoplasia with its associated complications like persistent pulmonary hypertension of the newborn (PPHN), air leaks and respiratory failure. Here we present a successful outcome following PPROM at about 18 weeks of gestation, with severe oligohydramnios leading to preterm delivery with suspected pulmonary hypoplasia and pneumothorax in the baby.
Axial tensile properties and flexibility characteristics of elementary units from multidimensional bamboo-based composites: radial and tangential moso bamboo slivers
Authors: Deng Jianchao , Wang Ge 
Published: May 2018

Abstract
Bamboo sliver (BS) is a potential elementary unit for multidimensional bamboo-based composites (MBBCs). Axial tensile and flexibility characteristics of thin radial (R) and tangential (T) BSs (BSR and BST with a thickness of 0.5–2.0 mm) have been studied. Axial tensile strength (AxTS) and modulus of elasticity (AxMOE) were positively correlated with the vascular tissue ratio (VTR), and the tensile properties of slices with 43–51% VTR increased more rapidly than in the VTR range of 20–36%. In axial tensile tests, cracks propagated along a V or Z route in BSR, while fibers were pulled out in the central section in case of BST. AxTS and AxMOE values increased with decreasing moisture content (MC) at 6.2–16.6% below 75°C. Flexural flexibility (FF) was enhanced with increasing MC and VTR, and the effect of MC on FF was amplified with MCs below the fiber saturation point (FSP). In situ scanning electron microscope (SEM) observation during flexural tests revealed a deformation resistance of vascular tissue (VT) and the deformation disposition of parenchyma.
Inverse dynamic and spectral problems for the one-dimensional Dirac system on a finite tree
Authors: Mikhaylov Alexander , Mikhaylov Victor S. , Murzabekova Gulden 
Published: May 2018

Abstract
We consider inverse dynamic and spectral problems for the one-dimensional Dirac system on a finite tree.
Our aim will be to recover the topology of a tree (lengths and connectivity of edges) as well as the matrix potentials on each edge.
As inverse data we use the Weyl–Titchmarsh matrix function or the dynamic response operator.
Synthesis and crystal structure of bis(furan-2-ylmethanaminium)-catena-[bis(μ2-phthalato-κ2
O:O′)cobalt(II)], C26H24CoN2O10
Authors: Said Musa A. , Hughes David L. , Shiekh Rayees Ahmad 
Published: May 2018

Abstract
C26H24CoN2O10, monoclinic, F2/d (equiv. to no. 15), a = 23.7125(7) Å, b = 10.7325(4) Å, c = 39.5740(15) Å, β = 90.324(3)°, V = 10071.2(6) Å3, Z = 16, R
gt(F) = 0.0514, wR
ref(F
2) = 0.1048, T = 140(1) K.
TMP properties and refiner conditions in a CD82 chip refiner at different operation points. Part II: Comparison of the five tests
Authors: Ferritsius Rita , Ferritsius Olof , Hill Jan , Karlström Anders , Eriksson Karin 
Published: May 2018

Abstract
This paper is part two of a study on a CD 82 TMP chip refiner where relations between changes in the process conditions and changes in the properties of the produced pulp are investigated. Focus is on the ratio between tensile index and specific energy consumption when results from five tests are compared. Pulp properties were measured for composite pulp samples taken from the refiner blow line. Residence times and pulp consistencies were estimated by use of the extended entropy model. Clearly, an increase in specific energy does not necessarily implicate an increase in strength properties of the pulp produced. It is of high importance to have access to information about the refining zone conditions when searching for an optimal operation point in terms of the ratio between tensile index and specific energy. In these tests, this ratio had a maximum at about 55 % measured blow line consistency. Unfavourable operating conditions were identified at high pulp consistencies, especially after the FZ, where pulp consistencies well above 70 % were observed. The estimated residence time for each refining zone responded differently when applying changes in production rate, plate gaps and dilution water flow rates. In conclusion, the results associated with estimated pulp consistencies where easier to interpret compared with results for residence times, implying that additional tests are required for the latter variable. In addition to tensile index, pulp properties like freeness, Somerville shives and light scattering coefficient were included in the analysis.
Control strategies for refiners Part II: Consistency control in twin-disc refining zones using temperature profile information
Authors: Karlström Anders , Hill Jan 
Published: May 2018

Abstract
Consistency profiles in the refining zones of twin-disc refiners have always been cumbersome to estimate with good accuracy. To overcome such challenges, this paper shows that it is vital to measure temperature profiles between the refining discs to estimate uneven chip/pulp feed distribution. It is also shown that the plate clearance, measured by plate gap measurement devices, is changed dramatically when changing the amount of dilution water to the refining zones asymmetrically. At the same time, the inlet temperature will change as well while the maximum temperature is rather stable. This makes the maximum temperature a good candidate for use when estimating the split of the pulp mass flow rates to the refining zones. This also opens for a new consistency control concept for each refining zone. The findings in this paper have been validated in a commercial TMP production line with two serially linked twin-disc refiners, and it is shown that the pulp and handsheet property variations, in terms of mean fiber length and tensile index, between the refining zones can be reduced considerably when running the refiners with similar consistency in each refining zone.
Indications of the onset of fiber cutting in low consistency refining using a refiner force sensor: The effect of pulp furnish
Authors: Harirforoush R. , Olson J. , Wild P. 
Published: May 2018

AbstractDetection of the onset of fiber cutting is beneficial in low consistency refining as it may prevent reduction of average fiber length, optimize fiber quality improvements by operating at gaps just wider than the critical gap, avoid decreasing the strength properties of paper, and increase energy efficiency. The objective of this study is to understand the effect of pulp furnish on measured bar forces and, more specifically, on the detection of fiber cutting. Bar forces, i. e. forces applied to pulp fibers by the refiner bars, are measured with a custom-designed piezoelectric force sensor. Trials were conducted with an AIKAWA 16-in. single-disc refiner using hemlock/balsam softwood thermomechanical pulp, SPF softwood thermomechanical pulp, northern bleached softwood kraft pulp, and aspen hardwood thermomechanical pulp at 3.0 to 3.5 % consistency at rotational speeds of 1200 and 1400 rpm. The power of the time domain signal of the measured forces is introduced as an indicator of the onset of fiber cutting. Our results show that this new fiber cutting metric is a sensitive and reliable metric for determination of fibre cutting for a range of pulp furnishes. The study suggests that the refiner force sensor has potential to be exploited for in-process detection of fiber cutting.