bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving ESP Reliability and Increasing Production in Challenging Conditions Through Real-Time Surveillance: A Case Study in Qarun Fields
Authors: Abdelmotaal Hatem , Ghaleb Ali , El-Hamid Ahmed Abd , Mahmoud Ahmed , Mohamed Hasan , El-Wahab Ahmed Abd , Munoz Miguel , El-Mageed Said Abd , El-Gawad Ashraf Abd 
Published: November 2018

AbstractElectrical submersible pumps (ESPs), one of the main artificial lift methods employed in the Western Desert of Egypt, can significantly influence the operating costs associated with producing assets. ESP well interventions are typically complex and costlier than other artificial lift-related workovers. Consequently, it is important that operators develop a strategy to closely monitor ESP-lifted producing wells to maximize production potential, ESP efficiency, and run-life. This case study reviews the experience gained from developing a monitoring program and response strategy to optimize ESP well value in Egypt.Qarun Petroleum Company (QPC), one of the main operators in the Western Desert of Egypt, operates more than 340 ESP producing wells. Similar to other ESP operators in the area, QPC deals with a range of challenges that can affect ESP performance, run-life, and ESP uptime. To address these challenges, a number of wells were selected for a monitoring program based on the transmission of downhole sensor and surface data. The program called for dedicated surveillance engineers to analyze and review the data in real time to identify any suspicious events that may pose a risk to the ESP's performance. Furthermore, a robust communication workflow was developed to enable the surveillance engineers, field operators, and production engineers to communicate, identify root causes of the captured events, and take corrective actions in a timely manner. Actions could then be executed remotely, eliminating health, safety, and environment risks and reducing the time required to optimize the performance of the ESP wells.The surveillance system proved to be valuable in several instances. Events that could have drastically affect production, such as motor overheating and gas interference were detected in real time. Flow recirculation was also identified more rapidly than without the system; thus, improving operational responsiveness and reducing deferred production. In addition, an ESP failure was avoided by optimizing the pump speed automatically to avoid gas-locking effects without compromising production. This study showed that production gains up to 9,000 BOPD were possible. Moreover, significant improvements in ESP run-life was observed in the monitored wells when compared with premonitoring performance.Field case studies are used in this study to demonstrate the well production and operating expenditure improvements resulting from real-time surveillance and continuous performance monitoring for ESP wells and fields.
ESP Runlife Improvement through Auditing of ESP Workshops
Authors: Edries Tamer , Sayed Eid , Abuelneel Mahmoud , Gahlan Ibrahim , Dwiggins Jeff , Dwiggins Chase , Ghazaly Safwat 
Published: November 2018

Abstract
A continuous process improvement programme was undertaken to further enhance electric submersible pump runlife in Egypt. Certain improvements had previously been achieved. However the process improvement team noted that suppliers systems did not remain consistent and that an ongoing effort for improvement must be achieved. This paper presents the audit teams efforts to implement a system for continual process improvement. This system that has been put in place will yield ongoing ESP runlife improvement.
The initial step of the process calls for a detailed system review. This required a team of 4-6 experienced auditors broken into working teams. Each of the suppliers processes are carefully audited in detail. From this effort, a detailed list of findings is developed that leads to a corrective action plan. The corrective action plan requires routine feedback (typically monthly) on goal achievement.
The process calls for setting goals, verification of goals and ongoing corrective action plans. Where warranted, these process improvements will be pushed deeper into the supplier's organization to ensure that these improvements are maintained on an ongoing basis. The method for completing this process is through a detailed auditing system. Through the auditing process, significant improvements have been achieved that have led to ESP runlife improvement.
EGPC, Khalda Petroleum and Artificial Lift Solutions have developed a unique process for auditing and ensuring process improvement.
Experimental Investigation of the Effect of Oil on Steady-State Foam Flow in Porous Media
Authors: Tang Jinyu , Vincent-Bonnieu Sebastien , Rossen William R. 
Published: November 2018

Summary
Foam flow in porous media without oil shows two regimes depending on foam quality (gas fractional flow). Complexity and limited data on foam/oil interactions in porous media greatly restrict understanding of foam in contact with oil. Distinguishing which regimes are affected by oil is key to modeling the effect of oil on foam. We report steady-state corefloods to investigate the effect of oil on foam through its effect on the two flow regimes. We fit the parameters of a widely used local-equilibrium (LE) foam model to data for concurrent foam/oil flow. This research provides a practical approach and initial data for simulating foam enhanced oil recovery (EOR) in the presence of oil.
To ensure steady state, oil is coinjected with foam at a fixed ratio of oil (Uo) to water (Uw) superficial velocities in a Bentheimer Sandstone core. Model oils used here consist of a composition of hexadecane, which is benign to foam stability, and oleic acid (OA), which can destroy foam. Varying the concentration of OA in the model oil allows one to examine the effect of oil composition on steady-state foam flow. Experimental results show that oil affects both high- and low-quality regimes, with the high-quality regime being more sensitive to oil. In particular, oil increases the limiting water saturation (Sw*) in the high-quality regime and also reduces gas-mobility reduction in the low-quality regime. Unevenly spaced ▿p contours in the high-quality regime suggest either strongly shear-thinning behavior or an increasingly destabilizing effect of oil. In some cases, the pressure gradient (▿p) in the low-quality regime decreases with increasing Uw at fixed gas superficial velocity (Ug), either with or without oil. This might reflect either an effect of oil, if oil is present, or easier flow of bubbles under wetter conditions. Increasing the OA concentration extends the high-quality regime to lower foam qualities, indicating more difficulty in stabilizing foam. Thus, oil composition plays as significant a role as oil saturation (So).
A model fit assuming a fixed Sw* and including shear thinning in the low-quality regime does not represent the two regimes when the oil effect is strong enough. In such cases, fitting Sw* to each ▿p contour and excluding shear thinning in the low-quality regime yield a better match to these data. The dependency of Sw* on So is not yet clear because of the absence of oil-saturation data in this study. Furthermore, none of the current foam-simulation models captures the upward-tilting ▿p contours in the low-quality regime.
Synthesis, characterization and filtration performance of the polyvinylidene fluoride membrane modified by poly(methyl ethacrylate-co-2-acrylamido-2-methylpropane sulfonic acid)
Authors: Zhang Q. Y. , An Q. , Guo Y. G. , Zhang J. , Zhao K. Y. 
Published: November 2018

Abstract
To enhance the anti-fouling and separating properties of polyvinylidene fluoride (PVDF) membranes, an amphiphilic copolymer of methyl methacrylate and 2-acrylamido-2-methylpropane sulfonic acid, poly(MMA-co-AMPS), was designed and synthesized. Through a phase-inversion process, the poly(MMA-co-AMPS) were fully dispersed in the PVDF membrane. The properties of membrane including the surface and cross-section morphology, surface wettability and fouling resistance under different pH solutions were investigated. Compared to the unmodified PVDF membranes, the contact angles of modified PVDF membranes decreased from 80.6° to 71.6°, and the pure water flux increased from 54 to 71 L·m−2·h−1. In addition, the hybrid PVDF membrane containing 0.5 wt% copolymers demonstrated an larger permeability, better fouling resistance and higher recovery ratio via pure water backlashing, when it was compared with the other blend membranes, and the virgin one in the cyclic test of anti-fouling. The modified membranes with the copolymers possessed an outstanding performance and may be used for further water treatment applications.
The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms
Authors: Yang Shi-Kun , Zhang Hao-Ran , Shi Shu-Peng , Zhu Ying-Qiu , Song Na , Dai Qing , Zhang Wei , Gui Ming , Zhang Hao 
Published: November 2018

Background:
Systemic Lupus Erythematosus (SLE) is a polysystem autoimmune
disease that adversely affects human health. Various organs can be affected, including the
kidney or brain. Traditional treatment methods for SLE primarily rely on glucocorticoids and
immunosuppressors. Unfortunately, these therapeutic agents cannot prevent a high recurrence
rate after SLE remission. Therefore, novel therapeutic targets are urgently required.

Methods:
A systematic search of the published literature regarding the abnormal structure and
function of mitochondria in SLE and therapies targeting mitochondria was performed in several
databases.

Results:
Accumulating evidence indicates that mitochondrial dysfunction plays important
roles in the pathogenesis of SLE, including influencing mitochondrial DNA damage, mitochondrial
dynamics change, abnormal mitochondrial biogenesis and energy metabolism, mitophagy,
oxidative stress, inflammatory reactions, apoptosis and NETosis. Further investigation
of mitochondrial pathophysiological roles will result in further clarification of SLE. Specific
lupus-induced organ damage also exhibits characteristic mitochondrial changes.

Conclusion:
This review aimed to summarize the current research on the role of mitochondrial
dysfunction in SLE, which will necessarily provide potential novel therapeutic targets
for SLE.
Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes
Authors: Sheoran Reena , Khokra Sukhbir Lal , Chawla Viney , Dureja Harish 
Published: November 2018

Background:During past decades, liposomes have emerged as efficient carriers for drugs, diagnostics, vaccines, nutrients and other bioactive agents. Liposomes, the spherical vesicles consisting of phospholipids bilayer have the ability to encapsulate both lipophilic and hydrophilic drugs. Extensive studies have been done in the past for investigating a number of drugs and genes for controlled release with liposomal formulation. Liposomes have also been investigated for their use in cancer treatment. Liposomes offer various advantages because of their biocompatible, biodegradable, nontoxic and non-immunogenic nature.Methods:Liposomes have cell-specific targeting with important applications in the fields of nanotechnology like cancer therapy, diagnosis, gene delivery, cosmetics, agriculture and in food technology. They are prepared by various methods like sonication method, ethanol injection method, lipid film hydration method, micro-emulsion method.Conclusion:This review will provide an overview of classification, the various formulation methods, characterization, patented formulations and applications of liposomes with future prospects.
Mitochondria-Targeted Drugs
Authors: Zinovkin Roman A. , Zamyatnin Andrey A. 
Published: November 2018

Background:Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs. A number of pathologies are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory and metabolic conditions.Objective:This mini-review aims to highlight the role of mitochondria in pathophysiological conditions and diseases, to classify and summarize our knowledge about targeting mitochondria and to review the most important preclinical and clinical data relating to the antioxidant lipophilic cations MitoQ and SkQ1.Methods:This is a review of available information in the PubMed and Clinical Trials databases (US National Library of Medicine) with no limiting period.Results and Conclusion:Mitochondria play an important role in the pathogenesis of many diseases and possibly in aging. Both MitoQ and SkQ1 have shown many beneficial features in animal models and in a few completed clinical trials. More clinical trials and research efforts are needed to understand the signaling pathways influenced by these compounds. The antioxidant lipophilic cations have great potential for the treatment of a wide range of pathologies.
Subjective Self-Rated Speech Intelligibility and Quality of Life in Patients with Parkinson’s Disease in a Malaysian Sample
Authors: Chu Shin Ying , Tan Chai Li 
Published: November 2018

Objectives:
This study compared the Quality of Life (QOL) of individuals with Parkinson’s disease (PD) with a healthy control from a sample in Malaysia. The relationship between the QOL, age, gender, duration of disease, self-rated speech scale, and life satisfaction level was examined.

Methods:
Fifty-four individuals with PD and 55 non-PD control adults completed the Parkinson’s Disease Questionnaire-39 (PDQ-39) and rated their speech intelligibility [Self-Rated Speech Scale (SRSS)] and life satisfaction level [Life Satisfaction Scale (LSS)] on a 10-point scale.

Results:
PD participants reported significantly lower QOL scores than the control group (Mann-Whitney U). Although there was no significant relationship between the QOL, age, gender, and duration of disease for PD participants, moderately significant correlations were observed between QOL, LSS and SRSS ratings (Spearman correlation). Individuals with PD showed lower QOL and higher concern in their communication than the control group.

Conclusion:
Identifying patients’ perception of their speech performance could help clinicians to better understand patients’ needs when delivering speech therapy services.
Reaction Time to Visual Stimulus in Firefighters and Healthy Trained Subjects: A Preliminary Comparative Study
Authors: Perroni Fabrizio , Mol Eric , Walker Anthony , Alaimo Calogero , Guidetti Laura , Cignitti Lamberto , Baldari Carlo 
Published: November 2018

Background:

In order to stay safe, and to successfully complete their work, firefighters have to constantly assess and process large numbers of sensory stimuli and adapt to the inherent risks present in the working environment.

Objective:
The purposes of the present preliminary study were to analyse the speed of Reaction Time responses (RT) of Italian Firefighters and to compare their cognitive responses with non-firefighting subjects.

Methods:
Anthropometric (weight, height and BMI) and RT (time-to-completion –TTC-, mean of reaction time –MRT-, and errors made -E-) evaluations were administered at 16 volunteers (Age: 40.3 ± 6.7 yrs; BMI: 23.8 ± 2.3 kg/m2) divided in Firefighters (FG) and Control (CG) groups. RT test consisted of 3 trials (T1 = 1s of stimulus duration and 1s interval between stimulus and the other; T2 = 0.5s of stimulus duration and 1s interval between stimulus and the other; T3 = 0.5s of stimulus duration and 0.5s interval between stimulus and the other). Mann Whitney U test between groups was applied to asses differences (p ≤ 0.05) in TTC, MRT, and E while Friedmann test and Dunn-Sidak post hoc were used to evaluate significant differences in the 3 trials in each variable of each group.

Results:
No significant differences based on anthropometric parameters were observed between groups. Despite no significant differences emerged for TTC and MRT between groups, we observed significant differences in E between groups (CG = 4; FG =12) and in the 3rd condition in each variable of each group.

Conclusion:
Workout programs that integrate reaction time training with job performance should be created to increase job performance.
Serum miR-21 and miR-26a Levels Negatively Correlate with Severity of Cirrhosis in Patients with Chronic Hepatitis B
Authors: Jiang Shili , Jiang Wei , Xu Ying , Wang Xiaoning , Mu Yongping , Liu Ping 
Published: November 2018

Background and Objective: Accurately evaluating the severity of liver cirrhosis is essential
for clinical decision making and disease management. This study aimed to evaluate the value of circulating
levels of microRNA (miR)-26a and miR-21 as novel noninvasive biomarkers in detecting severity
of cirrhosis in patients with chronic hepatitis B.
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Methods: Thirty patients with clinically diagnosed chronic hepatitis B-related cirrhosis and 30 healthy
individuals were selected. The serum levels of miR-26a and miR-21 were quantified by qRT-PCR.
Receiver operating characteristic curve analysis was performed to evaluate the sensitivity and specificity
of the miRNAs for detecting the severity of cirrhosis.

Results:
Serum miR-26a and miR-21 levels were found to be significantly downregulated in patients
with severe cirrhosis scored at Child-Pugh class C in comparison to healthy controls (miR-26a p<0.01,
and miR-21 p<0.001, respectively). The circulating miR-26a and miR-21 levels in patients were positively
correlated with serum albumin concentration but negatively correlated with serum total bilirubin
concentration and prothrombin time. Receiver operating characteristic curve analysis revealed that
both serum miR-26a and miR-21 levels were associated with a high diagnostic accuracy for patients
with cirrhosis scored at Child-Pugh class C (miR-26a Cut-off fold change at ≤0.4, Sensitivity: 84.62%,
Specificity: 89.36%, P<0.0001; miR-21 Cut-off fold change at ≤0.6, Sensitivity: 84.62%, Specificity:
78.72%, P<0.0001).

Our results indicate that the circulating levels of miR-26a and miR-21 are closely related
to the extent of liver decompensation, and the decreased levels are capable of discriminating patients
with cirrhosis at Child-Pugh class C from the whole cirrhosis cases.
Estilo de vida y estado nutricional del adulto mayor del pueblo joven La Unión, Chimbote
Authors: Pardo Robles Yosselyn Mirelly , Rodríguez Núñez Yolanda 
Published: November 2018

El presente trabajo de investigación, de tipo cuantitativo, con diseño descriptivo, se realizó con el propósito de determinar el estilo de vida y el estado nutricional del adulto mayor del P.J. La Unión, sector 7, Chimbote, 2012. El universo muestral estuvo constituido por 171 adultos mayores de ambos sexos. Para la recolección de datos se aplicó tres instrumentos: la escala de estilo de vida, la ficha de valoración nutricional del adulto mayor y la tabla de valoración nutricional según índice de masa corporal (IMC) para adultos mayores (> 60 años). El análisis y el procesamiento de datos se realizaron en el Software SPSS versión 18.0, elaborándose tablas y gráficos simples y porcentuales. Se llegó a las siguientes conclusiones: La mayoría de adultos mayores del P.J. La Unión, sector 7, presenta un estilo de vida no saludable y un mínimo porcentaje tiene un estilo de vida saludable. En cuanto al estado nutricional de los adultos mayores, tenemos que, cerca de la mitad presenta un estado nutricional normal; casi la cuarta parte presenta sobrepeso; un porcentaje menor presenta delgadez y una mínima parte, obesidad. Los adultos mayores del P.J. La Unión, sector 7, con estilo de vida no saludable presentan en mayor porcentaje estado nutricional normal, sobrepeso, delgadez y obesidad, respectivamente; y los adultos con estilo de vida saludable presentan en mínimo porcentaje obesidad, sobrepeso normal y delgadez, respectivamente.
Revistas de literatura infantil y juvenil en el Perú
Authors: Lozano Alvarado Saniel E. 
Published: November 2018

En el presente texto se ofrece un panorama nacional sobre la publicación de revistas de literatura infantil en el Perú desde el siglo XIX hasta la actualidad. Se puede apreciar que esta actividad se realiza en varias ciudades y regiones del país, aunque, por lo general, no se trata de un proceso continuo, de periodicidad regular, sino que está expuesto a una serie de factores que no siempre favorecen una edición permanente. El propósito general que anima la edición de estas publicaciones es promover la difusión del libro y la lectura entre los niños y jóvenes, estimular la creatividad, difundir experiencias didácticas, difundir la publicación de nuevos libros y apoyar la educación. El trabajo está dirigido especialmente a los educadores, niños, jóvenes, escritores, editores, artistas gráficos y padres de familia.
Procesos metodológicos para la colocación de transmisores satelitales en tortugas marinas de caparazón duro en playas de anidación
Authors: Gallegos-Fernández Sandra A. , Cuevas Eduardo , Liceaga-Correa María De los Ángeles 
Published: November 2018

Las tortugas marinas son especies migratorias que ocupan diversos hábitats marinos y costeros a lo largo de toda su vida. El estudio de la distribución espacial y temporal de estos vertebrados se ha visto revolucionado con el avance de tecnologías como la telemetría satelital que en las últimas dos décadas ha incrementado sustancialmente su implementación. Esta tecnología atiende la necesidad de conocer y ubicar sus hábitats críticos (como son áreas de interanidación, migración, alimentación y reproducción) así como conocer sus movimientos migratorios para el entendimiento de su biología y protección, mediante la colocación de transmisores satelitales a individuos de tortugas marinas. Dado que el costo de un transmisor satelital es alto, su eficaz colocación en una tortuga de manera rápida, segura y firme es de vital interés para el investigador para procurar que el transmisor permanezca por un tiempo prolongado maximizando el aporte de información que favorezca a la investigación. En este contexto, el objetivo de la presente contribución es describir y documentar experiencias en la aplicación de pasos metodológicos para una colocación estandarizada y probada de transmisores satelitales en tortugas marinas con caparazón duro. Esta contribución representa una descripción documentada paso a paso en el camino de establecer bases claras y versátiles como referencia para el proceso de colocación de transmisores satelitales.
A máquina do Plea Bargain
Authors: Bisharat George 
Published: November 2018

Versão inicial deste texto constituiu palestra do autor no III Seminário Internacional do Instituto de Estudos Comparados em Administração Institucional de Conflitos (INCT-InEAC), realizado na UFF, Niterói, em fevereiro de 2013. Uma versão dessa palestra, em inglês, foi publicada em DILEMAS - Vol. 7 - no 3 - JUL/AGO/SET 2014 - pp. 767-795. O atual texto que aqui se publica foi traduzido da versão publicada em inglês por Fernanda Duarte, Rafael Mario Iorio Filho e Gabriel G. S. Lima de Almeida. A Revisão Técnica foi feita por Roberto Kant de Lima.
O uso do capital social nos distritos policiais e Conselhos Comunitários de Segurança (CONSEGs) de São Paulo
Authors: Santos Vanessa Orban Aragão 
Published: November 2018

Apesar das reclamações frequentes da população quanto a inoperância da delegacia no encaminhamento dos casos, há uma porcentagem dos boletins de ocorrência que saem da denúncia e iniciam a fase de inquérito. Haveria algum critério de escolha dos casos? A pesquisa investigou quais os critérios de seleção das delegacias para investigar casos criminais. Observou-se critérios vinculados às redes de relações entre conselhos de segurança e delegacias, possibilitando que decisões nos conselhos interfiram nas investigações das delegacias, e, do mesmo modo, que representantes das delegacias influam na dinâmica decisória dos conselhos.