bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfusion‐transmitted babesiosis: one state's experience
Authors: Klevens R. Monina , Cumming Melissa A. , Caten Evan , Stramer Susan L. , Townsend Rebecca L. , Tonnetti Laura , Rios Jorge , Young Carolyn T. , Soliva Susan , DeMaria Alfred 
Published: September 2018

BACKGROUNDThe risk for tickborne exposure to Babesia microti infection exists statewide in Massachusetts. Broad exposure complicates investigations of transfusion‐transmitted babesiosis (TTB). We summarize 8 years of the epidemiology of TTB and highlight the role of public health in prevention and control.STUDY DESIGN AND METHODSCases of babesiosis are routinely reported to the Massachusetts Department of Public Health. These are investigated to determine whether they meet the surveillance case definition and to identify whether they were potentially transfusion transmitted. Frequencies from 2009 to 2016 are described and incidence rates calculated using population denominators from the US census. Changes over time were analyzed using simple linear regression.RESULTSFrom 2009 to 2016, there were 2578 cases of babesiosis reported; of these, 45 (1.7%) were transfusion transmitted. Of the 45 cases of TTB, 15 (33%) received blood products from two or more suppliers. In 11 TTB cases, the Department of Public Health was notified first, who in turn notified the appropriate blood provider. In 2009, the crude rate of reported babesiosis was 1.2 per 100,000 population and increased significantly through 2016 to 7.8 per 100,000 population (p = 0.006). The number of blood donors reported with laboratory evidence of B. microti infection increased from 19 in 2012 to 78 in 2016; at the same time, the number of TTB cases decreased from six to three.CONCLUSIONTTB remains a major challenge, and blood donor screening strategies are currently in the process of implementation. While population and environmental changes facilitate increases in babesiosis, donor screening has the potential to eliminate TTB.
Noninvasive prenatal HPA‐1 typing in HPA‐1a negative pregnancies selected in the Polish PREVFNAIT screening program
Authors: Orzińska Agnieszka , Guz Katarzyna , Uhrynowska Małgorzata , Dębska Marzena , Mikula Michal , Ostrowski Jerzy , Ahlen Maria Therese , Husebekk Anne , Brojer Ewa 
Published: September 2018

BACKGROUNDAnti‐HPA‐1a alloantibodies in HPA‐1a negative mothers can lead to fetal/neonatal alloimmune thrombocytopenia (FNAIT). Noninvasive prenatal testing (NIPT) of HPA‐1a determines fetuses at risk and the course of maternal antenatal treatment.STUDY DESIGN AND METHODSThe aim was to develop and validate HPA‐1a NIPT by real‐time polymerase chain reaction (PCR) or next‐generation sequencing (NGS) for a high‐throughput screening setting. DNA from 328 plasma samples of 299 HPA‐1a negative pregnant women was examined for HPA‐1a by real‐time PCR and in two cases also by NGS (Ion Torrent). The results were compared with neonatal HPA‐1a genotyping in 281 cases.RESULTSHPA‐1a NIPT was negative in 44 of 51 HPA‐1a negative fetuses, inconclusive in five, and false positive in two. In 228 of 229 HPA‐1a positive fetuses, the NIPT results were positive (mean threshold cycle 36.0 ± 1.7) and inconclusive in one. In 22 cases with HPA‐1a positive fetuses analyzed twice, the sensitivity of HPA‐1a detection was significantly higher at 28 weeks compared with 16 to 20 weeks. NGS efficiently detected the ITGB3 coding HPA‐1a/b (1% and 5% fetal HPA‐1a reads).CONCLUSIONReal‐time PCR is reliable to predict the fetal HPA‐1a positive genotype in a screening study, but false‐positive results are reported in 4%, with unnecessary prenatal treatment if anti‐HPA‐1a is detected.
WTO trade policy review for Switzerland: In need for a new paradigm
Authors: Weder Rolf 
Published: September 2018

AbstractThis paper argues that the World Trade Organization (WTO) and one of its important instruments, Trade Policy Review (TPR), should refocus on what they were created for: trade policy. This strategy is shown to be well‐founded in international trade theory. In contrast, the TPR 2017 on Switzerland and Liechtenstein deals with a large number of policies that are not or only indirectly related to international trade, but lie at the core of a country's self‐identification and sovereignty. It is concluded that the world trade system would gain in political support and thus benefit if countries were limited in their interference at the border, but enjoyed more freedom in their national policies.
Reviewer Acknowledgements
Authors: Young James 
Published: September 2018

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 6, Number 10Agboola O. Paul, Universiti Teknologi Malaysia, MalaysiaAhmet Yıkmış, Abant Izzet Baysal Univeersity, TurkeyAmir Hossain, IBAIS University, BangladeshFroilan Mobo, Philippine Merchant Marine Academy, PhilippinesHenry Poduthas, West Texas A&M University, USAJihyoung Kim, Pyeongtaek University, South KoreaJulia M. Mack, Gannon University, USAMarja Känsälä, Finnish Institute of Occupational Health, FinlandMiriam Parise, Università Cattolica del Sacro Cuore, ItalyOzgur Demirtas, Inonu University, TurkeyPaula Hanasz, Australian National University, AustraliaShariq aziz butt, Superior University Lahore, PakistanSudershan Pasupuleti, The University of Texas, USA James YoungEditorial AssistantOn behalf of,The Editorial Board of International Journal of Social Science StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://ijsss.redfame.com
First-in-man experience of the Versi Retriever in acute ischemic stroke
Authors: Sakai Nobuyuki , Imamura Hirotoshi , Adachi Hidemitsu , Tani Shoichi , Tokunaga So , Funatsu Takayuki , Suzuki Keita , Adachi Hiromasa , Sasaki Natsuhi , Kawabata Shuhei , Akiyama Ryo , Horiuchi Kazufumi , Ohara Nobuyuki , Kono Tomoyuki , Fujiwara Satoru , Kaneko Naoki , Tateshima Satoshi 
Published: September 2018

ObjectiveTo describe our initial experience with the Versi Retriever for mechanical thrombectomy in patients with acute ischemic stroke.MethodsThis study is a single-center, single-arm, first-in-man registry under institutional review board control to evaluate the efficacy and safety of the new stent retriever, the Versi Retriever. Patients with acute ischemic stroke were consecutively enrolled between September and November 2017. The clinical and procedural data were retrospectively analyzed. The angiographic result after the procedure was self-graded based on the Thrombolysis in Cerebral Infarction (TICI) scale by each operator.ResultsEleven patients with a mean age of 69.4 years were treated with the Versi Retriever. Median National Institutes of Health Stroke Scale score on admission was 16 (IQR 10–34). The occluded vessel was located in the anterior circulation in 81.8%. Revascularization rates of TICI 2b–3 and TICI 3 at final angiogram were achieved in 100% and 63.6%, respectively. A favorable functional outcome (modified Rankin Scale 0–2) at 90 days was obtained in 72.7%. No symptomatic intracranial hemorrhage occurred and no procedure-related complication was observed.ConclusionsOur initial experience suggests that the Versi Retriever is a safe and effective stent retriever for mechanical thrombectomy in patients with acute ischemic stroke.Clinical trial registrationNCT03366818
Treatment of intracranial aneurysms using the pipeline flex embolization device with shield technology: angiographic and safety outcomes at 1-year follow-up
Authors: Martínez-Galdámez Mario , Lamin Saleh M , Lagios Konstantinos G , Liebig Thomas , Ciceri Elisa F , Chapot Rene , Stockx Luc , Chavda Swarupsinh , Kabbasch Christoph , Faragò Giuseppe , Nordmeyer Hannes , Boulanger Thierry , Piano Mariangela , Boccardi Edoardo P 
Published: September 2018

PurposeThe Pipeline Embolization Device (PED) is a routine first-line treatment option for intracranial aneurysms (IAs). The Pipeline Flex Embolization Device with Shield Technology (Pipeline Shield) is an updated version of the PED which has been modified to include a surface phosphorylcholine biocompatible polymer. Its early technical success and safety have been reported previously. Here, we assessed the long-term safety and efficacy of the Pipeline Shield for the treatment of IAs.Materials and methodsThe Pipeline Flex Embolization Device with Shield Technology (PFLEX) study was a prospective, single-arm, multicenter study for the treatment of unruptured IAs using the Pipeline Shield. The primary endpoint was a major stroke in the territory supplied by the treated artery or neurologic death at 1-year post-procedure. Angiographic outcomes were also assessed by an independent radiology laboratory at 6 months and 1 year.ResultsFifty patients (mean age, 53 years; 82% female) with 50 unruptured IAs were treated. Mean aneurysm diameter was 8.82±6.15 mm. Of the target aneurysms, 38/50 (76%) were small (<10 mm), 11/50 (22%) were large (≥10 and<25 mm), and 1/50 (2%) was giant (≥25 mm). Forty-seven (94%) were located in the internal carotid artery and three (6%) in the vertebral artery. At 1-year post-procedure, no major strokes or neurologic deaths were reported, and complete occlusion was achieved in 27/33 (81.8%). There were no instances of aneurysm recurrence or retreatment.ConclusionsOur 1-year follow-up concerning angiographic and safety outcomes corroborate previous evidence that the Pipeline Shield is a safe and effective treatment for IAs.Trial registration numberNCT02390037
Comparative study of magneto-transport and lattice-vibrational properties of La2/3Ca1/3MnO3 thin films grown on SrTiO3 and LaAlO3 substrates
Authors: Xie Qiyun , Zhou Xuran , Qi Chao , Bai Gang , Chen Limin , Cheng Guofeng 
Published: September 2018

Epitaxial La[Formula: see text]Ca[Formula: see text]MnO3 (LCMO) thin films of 60 nm are deposited on (001)-oriented SrTiO3 (STO) and LaAlO3 (LAO) substrate by modified off-axis magnetron sputtering method. The strain state of the films have been studied by high resolution X-ray diffraction. The magneto-transport properties were found to be strongly dependent on the substrate used. Compared with LCMO/LAO film (compressive strain), LCMO/STO film with tensile strain exhibits lower metal-insulator transition temperature, suppressed Curie temperature, higher resistivity and more localization of electron. The evolution of the Raman modes has also been investigated. The vibrational mode of LCMO/LAO is comparable to the bulk, while the signature of vibration mode at about 610 cm[Formula: see text] induced by strain-related distortion has been observed only in tensile strained LCMO/STO case. The controversial 660 cm[Formula: see text] peak is not observed in our films, which precludes the possible existence of Mn3O4 precipitates in the films.
NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion
Authors: Vukelic Sasa , Xu Qian , Seidel-Rogol Bonnie , Faidley Elizabeth A. , Dikalova Anna E. , Hilenski Lula L. , Jorde Ulrich , Poole Leslie B. , Lassègue Bernard , Zhang Guogang , Griendling Kathy K. 
Published: September 2018

Objective—
Actin cytoskeleton assembly and organization, as a result of focal adhesion (FA) formation during cell adhesion, are dependent on reactive oxygen species and the cellular redox environment. Poldip2 (polymerase δ-interacting protein 2), a novel regulator of NOX4 (NADPH oxidase 4), plays a significant role in reactive oxygen species production and cytoskeletal remodeling. Thus, we hypothesized that endogenous reactive oxygen species derived from Poldip2/NOX4 contribute to redox regulation of actin and cytoskeleton assembly during integrin-mediated cell adhesion.

Approach and Results—

Using vascular smooth muscle cells, we verified that hydrogen peroxide (H
2
O
2
) levels increase during integrin-mediated cell attachment as a result of activation of NOX4. Filamentous actin (F-actin) was oxidized by sulfenylation during cell attachment, with a peak at 3 hours (0.80±0.04 versus 0.08±0.13 arbitrary units at time zero), which was enhanced by overexpression of Poldip2. Depletion of Poldip2 or NOX4 using siRNA, or scavenging of endogenous H
2
O
2
with catalase, inhibited F-actin oxidation by 78±26%, 99±1%, and 98±1%, respectively. To determine the consequence of F-actin oxidation, we examined the binding of F-actin to vinculin, a protein involved in FA complexes that regulates FA maturation. Vinculin binding during cell adhesion as well as migration capacity were inhibited after transfection with actin containing 2 oxidation-resistant point mutations (C272A and C374A). Silencing of Poldip2 or NOX4 also impaired actin–vinculin interaction, which disturbed maturation of FAs and inhibited cell migration.

Conclusions—
These results suggest that integrin engagement during cell attachment activates Poldip2/Nox4 to oxidize actin, which modulates FA assembly.
Recent Third Pole’s Rapid Warming Accompanies Cryospheric Melt and Water Cycle Intensification and Interactions between Monsoon and Environment: Multidisciplinary Approach with Observations, Modeling, and Analysis
Authors: Yao Tandong , Xue Yongkang , Chen Deliang , Chen Fahu , Thompson Lonnie , Cui Peng , Koike Toshio , Lau William K.-M. , Lettenmaier Dennis , Mosbrugger Volker , Zhang Renhe , Xu Baiqing , Dozier Jeff , Gillespie Thomas , Gu Yu , Kang Shichang , Piao Shilong , Sugimoto Shiori , Ueno Kenichi , Wang Lei , Wang Weicai , Zhang Fan , Sheng Yongwei , Guo Weidong , Ailikun  , Yang Xiaoxin , Ma Yaoming , Shen Samuel S. P. , Su Zhongbo , Chen Fei , Liang Shunlin , Liu Yimin , Singh Vijay P. , Yang Kun , Yang Daqing , Zhao Xinquan , Qian Yun , Zhang Yu , Li Qian 
Published: September 2018

AbstractThe Third Pole (TP) is experiencing rapid warming and is currently in its warmest period in the past 2,000 years. This paper reviews the latest development in multidisciplinary TP research associated with this warming. The rapid warming facilitates intense and broad glacier melt over most of the TP, although some glaciers in the northwest are advancing. By heating the atmosphere and reducing snow/ice albedo, aerosols also contribute to the glaciers melting. Glacier melt is accompanied by lake expansion and intensification of the water cycle over the TP. Precipitation has increased over the eastern and northwestern TP. Meanwhile, the TP is greening and most regions are experiencing advancing phenological trends, although over the southwest there is a spring phenological delay mainly in response to the recent decline in spring precipitation. Atmospheric and terrestrial thermal and dynamical processes over the TP affect the Asian monsoon at different scales. Recent evidence indicates substantial roles that mesoscale convective systems play in the TP’s precipitation as well as an association between soil moisture anomalies in the TP and the Indian monsoon. Moreover, an increase in geohazard events has been associated with recent environmental changes, some of which have had catastrophic consequences caused by glacial lake outbursts and landslides. Active debris flows are growing in both frequency of occurrences and spatial scale. Meanwhile, new types of disasters, such as the twin ice avalanches in Ali in 2016, are now appearing in the region. Adaptation and mitigation measures should be taken to help societies’ preparation for future environmental challenges. Some key issues for future TP studies are also discussed.
Effects From Continuous Infusions of Dexmedetomidine and Propofol on Hemodynamic Stability in Critically Ill Adult Patients With Septic Shock
Authors: Nelson Kristen M. , Patel Gourang P. , Hammond Drayton A. 
Published: September 2018

Purpose: To compare the development of clinically significant hemodynamic event (ie, hypotension or bradycardia) in adults with septic shock receiving either propofol or dexmedetomidine. Materials and Methods: A retrospective cohort study of adults with septic shock admitted to an intensive care unit (ICU) at an academic medical center between July 2013 and July 2017. Results: Patients in the propofol (n = 35) and dexmedetomidine (n = 37) groups developed a clinically significant hemodynamic event at similar frequencies (31.4 vs 29.7%, P = .99). All patients with an event experienced hypotension, whereas 2 (5.4%) patients in the dexmedetomidine group also experienced bradycardia. Most patients in both groups (70% vs 90%) received an escalating sedative dose, and almost half (42.9%) in the dexmedetomidine group had the sedative dosage increased more frequently than every 30 minutes. Patients in both groups had similar ICU (24.1 vs 24.3 days, P = .98) and hospital (37.9 vs 29.7 days, P = .29) lengths of stay. There was no difference in median time to hemodynamic event between the groups (propofol 1 hour [interquartile range, IQR: 0.5-9.9] vs dexmedetomidine 2 hours [IQR: 1.5-11.1 hours], P = .85). Conclusion: Patients with septic shock receiving propofol or dexmedetomidine experienced similar rates of clinically significant hemodynamic events. Most patients did not experience an event and those who did most frequently did so in the first couple of hours of therapy.
A Comparative Cephalometric Study of Nasoalveolar Molding– and Non-Nasoalveolar Molding–Treated Bilateral Cleft Patients at Early Mixed Dentition Period
Authors: Nayak Tulasi , Bonanthaya Krishnamurthy , Parmar Renu , Shetty Pritham N. , Rao Dipesh D. 
Published: September 2018

Objective: To evaluate and compare early maxillary growth in 2 groups of patients with repaired bilateral cleft lip and palate (BCLP) who had and had not received nasoalveolar molding (NAM) therapy in infancy. Hypothesis: Nasoalveolar molding does not have any effect on maxillomandibular growth at the early mixed dentition period. Design: Retrospective study. Patients: The study group consisted of forty-two 7-year-old patients with BCLP—20 in the NAM group and 22 in the no-NAM group. The control group consisted of nineteen 7-year-old noncleft, normal patients. Interventions: Nasoalveolar molding was carried out prior to surgeries in those children who were brought in within 8 weeks of birth. Children brought in later were treated without a presurgical intervention. All patients were treated with a single-stage modified Millard cheiloplasty without gingivoperiosteoplasty. Palatoplasty was done by single-stage Bardach palatoplasty with muscle repositioning. Mean Outcome Measures: Hard tissue and dental cephalometric values measured on lateral cephalograms, recorded at 7 years of age. Results: A comparison of the mean sagittal values showed a statistically significant maxillomandibular retrusion and incisor retroclination of both BCLP groups in comparison to the control group. None of the cephalometric parameters varied statistically between NAM and no-NAM groups. The maxillomandibular relation, lower face height ratio, mandibular plane, and mandibular axis angles did not show statistically significant difference between all 3 groups. Conclusions: On the basis of this study, NAM does not have any effect on maxillomandibular growth at the early mixed dentition period.
ACTB and SDHA Are Suitable Endogenous Reference Genes for Gene Expression Studies in Human Astrocytomas Using Quantitative RT-PCR
Authors: Röhn Gabriele , Koch Arend , Krischek Boris , Stavrinou Pantelis , Goldbrunner Roland , Timmer Marco 
Published: September 2018

Background: Quantitative real-time reverse-transcription polymerase chain reaction is frequently used as research tool in experimental oncology. There are some studies of valid endogenous control genes in the field of human glioma research, which, however, only focus on the comparison between normal brain with tumor tissue and malignant transformation toward secondary glioblastomas. Aim of this study was to validate a more general reference gene also suitable for pre- and posttreatment analysis and other evaluations (eg, primary vs secondary glioblastoma). Methods: This quantitative polymerase chain reaction analysis was performed to test a panel of the 6 most suitable reference genes from other studies representing different physiological pathways (ACTB, GAPDH, POLR2A, RPL13A, SDHA, and TBP) in all common glioma groups, namely: diffuse astrocytoma World Health Organization II, anaplastic astrocytoma World Health Organization III, secondary glioblastoma World Health Organization IV with and without chemotherapy, primary glioblastoma, recurrent glioblastoma, and gliomas before and after radiation. Expression stability was tested during the longitudinal course of the disease in 8 single patients. Results: Evaluation of the expression levels of the 6 target genes showed that ACTB, GAPDH, and RPL13A show higher expression compared to SDHA, POLR2A, and TBP. ACTB, GAPDH, and RPL13A showed different expression levels between astrozytoma grade II and primary glioblastoma. Except for this difference, the candidate genes were not differentially expressed between primary and secondary glioblastomas and between the World Health Organization tumor grades. Furthermore, they remained stable before and after radiotherapy and/or chemotherapy. Therefore, they are adequate references for glioblastoma gene expression studies. The comparison of all tested genes resulted in SDHA and ACTB as most stable reference genes determined by the NormFinder software. Our data revealed lowest intragroup variation in the SDHA, highest in the RPL13A gene. Conclusions: All tested genes may be recommended as universal reference genes for data normalization in gene expression studies under different treatment regimens both in primary glioblastomas and astrocytomas of different grades (World Health Organization grades II-IV), respectively. In summary, ACTB and SDHA exhibited the best stability values and showed the lowest intergroup expression variability.