bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences
Authors: Hatami Mahsa , Abdolahi Mina , Soveyd Neda , Djalali Mahmoud , Togha Mansoureh , Honarvar Niyaz Mohammadzadeh 
Published: November 2018

Objective:
Neuroinflammatory disease is a general term used to denote the progressive loss
of neuronal function or structure. Many neuroinflammatory diseases, including Alzheimer’s, Parkinson’s,
and multiple sclerosis (MS), occur due to neuroinflammation. Neuroinflammation increases
nuclear factor-κB (NF-κB) levels, cyclooxygenase-2 enzymes and inducible nitric oxide synthase,
resulting in the release of inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1β)
and tumor necrosis factor-α (TNF-α). It could also lead to cellular deterioration and symptoms of neuroinflammatory
diseases. Recent studies have suggested that curcumin (the active ingredient in turmeric)
could alleviate the process of neuroinflammatory disease. Thus, the present mini-review was
conducted to summarize studies regarding cellular and molecular targets of curcumin relevant to neuroinflammatory
disorders.

Methods:
A literature search strategy was conducted for all English-language literature. Studies that
assessed the various properties of curcuminoids in respect of neuroinflammatory disorders were included
in this review.

Results:
The studies have suggested that curcuminoids have significant anti- neuroinflammatory, antioxidant
and neuroprotective properties that could attenuate the development and symptom of neuroinflammatory
disorders. Curcumin can alleviate neurodegeneration and neuroinflammation through multiple
mechanisms, by reducing inflammatory mediators (such as TNF-α, IL-1β, nitric oxide and NF-κB
gene expression), and affect mitochondrial dynamics and even epigenetic changes.

Conclusion:
It is a promising subject of study in the prevention and management of the
neuroinflammatory disease. However, controlled, randomized clinical trials are needed to fully evaluate
its clinical potential.
“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip
Authors: Poloznikov Andrey A. , Nikulin Sergey V. , Zakhariants Arpenik A. , Khristichenko Anna Y. , Hushpulian Dmitry M. , Gazizov Ildar N. , Tishkov Vladimir I. , Gazaryan Irina G. 
Published: November 2018

Background:
“Branched tail” oxyquinolines, and adaptaquin in particular, are potent HIF
prolyl hydroxylase inhibitors showing promising results in in vivo hemorrhagic stroke models. The further
improvement of the potency resulted in identification of a number of adaptaquin analogs. Early
evaluation of toxicity and metabolism is desired right at the step of lead selection.

Objective:
The aim of the study is to characterize the toxicity and metabolism of adaptaquin and its
new improved analogs.

Method:
Liver-on-a-chip technology with differentiated HepaRG cells followed by LC-MS detection
of the studied compounds and metabolites of the P450 substrate-inhibitor panel for CYP2B6, CYP2C9,
CYP2C19, and CYP3A4.

Results:
The optimized adaptaquin analogs show no toxicity up to a 100-fold increased range over
EC50. The drugs are metabolized by CYP3A4 and CYP2B6 as shown with the use of the cytochrome
P450 substrate-inhibitor panel designed and optimized for preclinical evaluation of drugs’ in vitro
biotransformation on a 3D human histotypical cell model using “liver-on-a-chip” technology. Activation
of CYP2B6 with the drugs tested has been observed. A scheme for adaptaquin oxidative conversion
is proposed.

Conclusion:
The optimized adaptaquin analogs are suitable for further preclinical trials. Activation of
CYP2B6 with adaptaquin and its variants points to a potential increase in Tylenol toxicity if administered
together.
Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy
Authors: Malek Vajir , Sharma Nisha , Gaikwad Anil Bhanudas 
Published: November 2018

Background:Natriuretic peptide system (NPS) alterations are involved in pathogenesis of diabetic cardiomyopathy (DCM) and nephropathy (DN), however its epigenetic regulation is still unclear. Interestingly, histone acetylation epigenetically regulates neprilysin expression in Alzheimer’s disease.Objectives:The present study was aimed at delineating role of histone acetylation in regulation of NPS in DCM and DN.Methods:Streptozotocin (55 mg/kg, i.p.)-induced diabetic male Wistar rats were used to mimic pathogenesis of DCM and DN. After haemodynamic measurements, all the rat’s plasma, heart and kidney were collected for biochemistry, ELISA, protein isolation and western blotting, RT-PCR and chromatin immunoprecipitation (ChIP) assay.Results:Diabetic rats heart and kidney exhibited activation of NF-κB and TGF-β signalling with increased histone acetyl transferases (PCAF/CBP) expressions and augmented H2AK5Ac, H2BK5Ac, H3K18Ac, and H4K8Ac levels. ChIP assay results showed increased enrichment of H3K18Ac and H2BK5Ac at Nppa, Nppb (Heart) and Mme promoter (Heart/Kidney) in diabetic rats. Enrichment of H2AK5Ac was augmented on Nppa and Mme promoters in diabetic heart, while it remained unchanged on Nppb promoter in heart and Mme promoter in kidney.Conclusion:Augmented histone acetylation at promoter regions of NPS gene(s), at least in a part, is responsible for increased expressions of ANP, BNP and NEP in diabetic heart and kidney. Hence, histone acetylation inhibitors can be considered as novel therapeutic targets against DCM and DN.
A Data Placement Strategy Based on Crow Search Algorithm in Cloud Computing
Authors: Kaur Avinash , Gupta Pooja , Singh Manpreet 
Published: November 2018

Background:
In cloud computing era, large scale scientific applications process large
amount of data in the data centers. Placing of this data onto a data center is a critical issue performed
as part of workflow management system and aims to find the best data center to place
the data. It has a direct impact on performance, cost and execution time of workflows.

Methods:
In this paper, a novel data placement strategy is proposed based on Crow Search Algorithm
(CSA) that dynamically distributes the data sets to appropriate data centers during runtime
stage of workflow.

Results:
The results obtained b y CSA based run time data placement algorithm are evaluated
with the results of other algorithms. Simulation results acknowledge that using CSA based data
placement algorithm provides appropriate results in comparison to the other algorithms.
Phycoremediation of Municipal Wastewater by the Cold‐Adapted Microalga Monoraphidium sp. Dek19
Authors: Hage Adam , Luckett Nolan , Holbrook Gabriel P. 
Published: November 2018

ABSTRACT Present municipal wastewater treatment technologies often require substantial energy inputs, and fail to completely remove nitrate and phosphate before discharging effluent. In contrast, using the cold‐adapted oleaginous microalga Monoraphidium sp. Dek 19 decreased levels of both these polluting ions to 0 mg/dL. Concurrent biomass production was greater at 10 °C than at 22 °C, showing that phycoremediation occurred at low temperatures previously thought to be unsuitable for algal‐based treatment. Algal growth with uptake of nitrate and phosphate required only short bursts of aeration to suspend cells and maintain CO2 supply for photosynthesis. To save energy, culture aeration for 1 hour, 4 times per day, including during the dark cycle, yielded cell productivity and phycoremediation nearly equivalent to using 24‐hour aeration. The authors conclude that Monoraphidium sp. Dek19 algae represent an economical effluent treatment at cool temperatures found in the high proportion of water resource recovery facilities in geographical areas experiencing cold winters.
Impact of Nutrient Availability on Tertiary Wastewater Treatment by Chlorella vulgaris
Authors: Chamberlin John , Harrison Kristen , Zhang Wen 
Published: November 2018

ABSTRACT: Algae can use excessive nutrients from wastewater effluent to generate beneficial products such as biofuels. However, fluctuation of wastewater characteristics could hinder the implementation of tertiary algal treatment. This study aims to identify the impact of nutrient availability on Chlorella vulgaris's ability to remove nitrogen and phosphorus from wastewater, and its potential as a biofuel feedstock. Experiments using synthetic wastewater with varying concentrations of nitrate and phosphate showed C. vulgaris continued to remove either nutrient when the other was exhausted. Nitrogen starvation led the algae to accumulate the highest amount of neutral lipid; however, the exhaustion of phosphorus did not produce such impact. Synergistic effect was also observed between C. vulgaris and indigenous microorganisms in nutrient removal from real wastewater effluent. The results showed C. vulgaris can survive in a range of nutrient‐limiting conditions, making tertiary algal treatment applicable following various secondary treatment regimes.
Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan
Authors: Lai Shih-Wei , Lin Cheng-Li , Liao Kuan-Fu 
Published: November 2018

OBJECTIVE
No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study’s aim was to assess this issue in Taiwan.

RESEARCH DESIGN AND METHODS
A population-based cohort study was performed to analyze the database of Taiwan’s National Health Insurance Program. There were 27,869 subjects aged 20–84 years with newly diagnosed diabetes from 2000 to 2012 as the group with diabetes. The group without diabetes included 111,476 sex- and age-matched subjects without diabetes. The incidence of avascular necrosis of the femoral head at the end of 2013 was measured. A multivariable Cox proportional hazards regression model was used to measure the hazard ratio (HR) and 95% CI for avascular necrosis of the femoral head associated with diabetes.

RESULTS
The overall incidence of avascular necrosis of the femoral head was 1.37-fold higher in the group with diabetes than in the group without diabetes (6.53 vs. 4.76 per 1,000 person-years [95% CI 1.31–1.43]). After adjusting for confounders, the HR of avascular necrosis of the femoral head was 1.16 (95% CI 1.11–1.21) for the subjects with diabetes compared with the subjects without diabetes.

CONCLUSIONS
Patients with diabetes have a 1.16-fold increased risk for developing avascular necrosis of the femoral head.
ANALYSIS OF SHALLOW SUBSURFACE AT HYDROCARBON POTENTIAL AREAS IN NORTH ACEH BASED ON ELECTRICAL RESISTIVITY MODEL
Authors: Aflah Nurul , Muchlis Muchlis , Idris Syafrizal , Ardjakusumah Witan O 
Published: November 2018

Hydrocarbon prospect area research has been done in North Aceh at two locations. The research aims to analyze subsurface litology using resistivity method. Data acquisition of each location was presented by 330 m line survey. The acquisition process was generated by Super Sting R8/IP and modelled by EarthImager 2D. Oil and gas (NA1) resistivity section showed anomaly at 170 m (x) and 17 m (z) that was identified as minor fault. However, oil seepage was not founded on the location. Fossil locality (NA2) section showed a contrast vertical anomaly (16-90 Ωm) around 90 – 120 m that was identified as a way for the seepage.
Lenkung und Ablenkung - Zu den Regiebemerkungen bei John von Düffel, Peter Handke und Franz Xaver Kroetz
Authors: Honegger Serge Brian 
Published: November 2018

Sprache und Schrift steuern Handlungen und Wahrnehmungen von Adressaten. Dabei praktizieren Texte eine Führungsmodalität, die sich im Spannungsfeld von ‹Vorschreiben› und ‹Offenlassen› bewegt. Den Gegenstand der Publikation bilden vier Theaterstücke ohne Figurenreden von John von Düffel, Peter Handke und Franz Xaver Kroetz. Im Textraum der Regiebemerkungen reflektieren die Autoren die entmaterialisierenden Wirkungen in Bezug auf die Transformation des literarischen Textes ins Aufführungsmedium. Sie machen auf den Status des Schriftlichen　im Umfeld von Regietheater und beginnendem digitalen Zeitalter aufmerksam.
Allesamt in der zweiten Hälfte des 20. Jahrhunderts entstanden, lässt sich an den Dramentexten ein verändertes Verständnis von Führung und ‹Leadership› ablesen. Dieses verabschiedet sich von hierarchisch strukturierten Organisationsprinzipien sowie determinierenden Planbarkeits- und Kontrollvorstellungen.
DAMPAK URBANISASI BAGI PEMBANGUNAN MANUSIA 2010-2016 Studi Kasus: Jakarta, Surabaya dan Medan
Authors: Prasodjo Iwan 
Published: November 2018

This article discusses the effect of urbanization on Human Development Index during 2010-16. It shows that Jakarta has the highest population growth and Gross Domestic Regional Product. However, Surabaya has the highest Human Development Index. Eventhough, Jakarta, with the highest Gross Domestic Regional Product, does not indicate the highest Human Development Index. On the other hand, Medan has the lowest Gross Domestic Regional Product. Not only Medan has the lowest Gross Domestic Regional Product, but also it has the lowest Human Development Index.
A NOVEL APPROACH OF ARTESUNATE PELLETS FOR THE TREATMENT OF MALARIA
Authors: Shabaraya A. R. , Parulkar Ankit S , Kamath Krishnananda K , Shripathy D 
Published: November 2018

Tropical countries such as India are more prone to the malaria and around 2 million cases are reported annually. Malaria is one of the most prominent life threatening diseases in spite of many efforts made to fight against it. There are many clinically effective anti-malarial agents but the major reasons of malaria treatment failure are due to resistance development, incorrect dosing, poor drug quality, drug interactions, poor drug absorption and misdiagnosis. Current approach done in this study is to formulate a dosage form which can overcome these drawbacks. Here pellets of Artesunate were formulated by extrusion spheronization method using different concentration of ethyl cellulose and evaluated for preformulation studies, drug compatibility studies were carried out. Formulations were evaluated for particles size analysis, zeta potential and in-vitro dissolution studies. The pellets were obtained in the size range of 10 – 100µm. The evaluation results obtained showed that the formulation F4 having high concentration of ethyl cellulose showed the best release profile.
La fuga
Authors: Pineda Melgarejo Brianda 
Published: November 2018

Brianda Pineda Melgarejo estudió Lengua y Literatura Hispánicas en la UV. Ha publicado en La Palabra y el Hombre, F.I.L.M.E y Liberoamérica (traducciones y ensayo). Participó en el área de poesía en la XIV generación de la FLM.
Nuestras artistas de páginas interiores
Authors: De páginas interiores Nuestras artistas 
Published: November 2018

Atenea C.B es pintora e ilustradora egresada de la Facultad de Artes Plásticas de la Universidad Veracruzana. En 2016 ganó el premio de selección de la Tercera Bienal de Arte en Veracruz. Ha participado en alrededor de quince exposiciones colectivas y cinco individuales, la más reciente: Unus Mundus. En 2014 fue beneficiaria del Programa de Estímulos a la Creación y Desarrollo Artístico en Veracruz.Paulina Vilchis ha sido acreedora de la beca Jóvenes Creadores otorgada por el Ivec. Su técnica consiste en trabajar el grabado para intervenirlo después con otros materiales como el collage y la acuarela.
FIBROSIS QUÍSTICA EN PEDIATRÍA Y COMPROMISO PONDOESTAURAL
Authors: VELASCO BENITEZ CARLOS ALBERTO 
Published: November 2018

La fibrosis quística del páncreas, entidad hereditaria, autosómica recesiva, producto de las mutaciones en el gen que codifica la proteína reguladora de la conductancia transmembrana, es una entidad que si no se diagnóstica a tiempo es desvastadora desde el punto de vista nutricional. El compromiso de la fibrosis quística en el niño es multisistémico, principalmente respiratorio y digestivo (intestino, páncreas, hígado), que repercute en lo nutricional, y por ende la calidad de vida de los niños. El estudio de Jassim et al., presentado en este suplemento, busca evaluar el grado de afectación del crecimiento pondoestatural como efecto de la fibrosis quística del páncreas en los infantes que asisten a las IPS en Barranquilla entre 2013-2015. Jassim-Álvarez BR, Sara Quintero MA. Evaluación del grado de afectación del crecimiento pondoestatural como efecto de la fibrosis quística pancreática en infantes de 0 días de nacidos hasta los 18 años, que asisten a las Instituciones Prestadoras de Salud en Barranquilla (Centro de Atención Pulmonar: Clínica Porto Azúl) entre 2013 2015. Rev Gastrohnup 2015; 17 (3) Supl. 3: S5-S12
NUTRICIÓN EN EL NIÑO HIPERTENSO
Authors: MORENO GIRALDO LINA JOHANNA , HERRERA GENES ADELA 
Published: November 2018

La Hipertensión Arterial (HTA) en niños es un problema creciente en salud. Con una frecuencia estimada en niños del 1-13%, dependiendo de la metodología usada, es uno de los factores de riesgo más importantes para el desarrollo de enfermedad cardiovascular y renal crónica. En 2004, el Cuarto Informe, establece que los valores normales de la presión arterial en niños dependen del género, edad, percentil de talla y para su clasificación se utilizan actualmente las tablas de la National High Blood Pressure Education Program Working Group on High Blood Pressure Children and Adolescents, con los percentiles 50, 90, 95 y 99 de presión arterial sistólica y diastólica. Entre los factores en la patogenia de la HTA primaria ó esencial en pediatría está la obesidad, relacionada con el aumento del gasto cardíaco y del volumen intravascular, aumento de la actividad del sistema simpático, lesión endotelial por radicales libres, aumento de la generación de angiotensina a partir del tejido adiposo, hiperinsulinemia con aumento en la reabsorción de sodio y del tono simpático, de la leptina, además de aterosclerosis temprana, trastornos del sueño relacionados con síndromes de apnea e hipopnea. En los niños, las diferentes guías de manejo incluyendo las de la Organización Mundial de la Salud y de la Sociedad Internacional de Hipertensión (OMS/ISH), se plantean como objetivo terapéutico reconocido ampliamente, que una disminución en el consumo de sodio en niños y adolescentes se ha asociado con reducción en la PA, entre 1 a 3 mmHg. Por lo anterior, teniendo en cuenta las complicaciones en edades tardías de consumo de sal de la dieta desde la infancia y la aparición más frecuente de niños pequeños se debe determinar las necesidades de sodio en la dieta y dentro de las recomendaciones se debe preferir alimentos de origen natural y en lo posible no se debe agregar sal a las preparaciones en el niño menor de 2 años.
DOLOR ABDOMINAL Y PARÁSITOS INTESTINALES EN NIÑOS
Authors: VELASCO BENÍTEZ CARLOS ALBERTO 
Published: November 2018

Es conducta regular que ante todo niño con dolor abdominal en nuestros países en vía de desarrollo, el parasitismo intestinal sea tenido en cuenta. En este numero de la Revista Gastrohnup se presenta un artículo sobre Dolor abdominal en niños en donde se describe la fisiopatología del dolor abdominal así como semiológicamente como diferenciarlo en agudo, crónico y funcional, y dentro de estos, cuál es el papelque juegan los parásitos intestinales. En un segundo artículo de este número se realiza una revisión epidemiológica de un geohelmilto causante de dolor abdominal, el Ascaris lumbricoides y dentro del mismo su posible asociación con la presencia de dolor abdominal en niños. Finalmente hay un par de artículos sobre nutrición pediátrica: el primero de ellos sobre la alimentación normal en el lactante normal y el segundo sobre nutrición en el niño con enfermedad renal. El resto del numero de la Revista Gastrohnup está dedicado a una diversidad de artículos resultado de la productividad académica de algunos de los profesores de la Facultad de Salud de la Universidad delValle.
EPIDEMIOLOGÍA DEL ÁSCARIS LUMBRICOIDES EN PEDIATRÍA
Authors: GRIJALVA ZULUAGA DANIEL SANTIAGO 
Published: November 2018

Los parásitos intestinales son un problema grave en países en vía de desarrollo, entre ellos encontramos los geohelmintos siendo Áscaris lumbricoides el principal por su alta prevalencia causando una infección conocida como ascariasis que afecta principalmente niños en edad preescolar y escolar estando asociada a factores como falta de higiene, deficiencia en el saneamiento básico, geofagia, infección materna, falta de agua potable, consumo de alimentos crudos y sin lavar, etc. Este artículo es una revisión de la literatura reciente que examina la prevalencia de Áscaris lumbricoides en países en desarrollo sobretodo en Latinoamérica.
Kombinasi Campuran Limbah Kayu dan Non Kayu untuk Briket sebagai Bahan Bakar Alternatif
Authors: HS Suroto , Sirait Jantri 
Published: November 2018

Berdasarkan pengalaman dari proses moulding limbah yang diperoleh mencapai 25% dari volume kayu yang diolah. Jika kayu yang diolah sekitar 100 m3 per hari maka akan diperoleh limbah sekitar 25 m3. Jika dalam setu bulan bekerja 25 hari maka akan diperoleh limbah sebesar 625 m3. Jika diasumsikan hasil samping tempurunq kelapa sebesar 10% dengan rata-rata produksi kelapa di Kaltim sebesar 1.195.68 kg/Ha maka diperkirakan hasil sampingtempurung kelapa sebesar 119,57 Kg/Ha. Batubara saat ini merupeken hasil tambang yang potensial penghasil pendapatan asli daerah. Penggunaan utama batubara saat ini sebagai penghasil energi, namun pada sisi lain sebagian dimanfaa/kan un/uk briket batubara. Asal bahan baku briket saat ini kebanyakan mesih dalam bentuk tunggal (batubara, tempurung kelapa dan arang kayu). Dalam penelitian ini akan mengkombinasikan bahan limbah serbuk arang kayu, tempurung kelapa dan batubara. Hasil menunjukan kualitas briket tunggal dengan parameter nilai kalor berturut-turut 5.419 cal/g bengkirai (B), 5.324 cal/g batubara (Bb), 4.356 cal/g tempurung kelapa {Tk}, 4.126 cal/g ulin (U), dan 4.087 ca//g merent! (M). Sedangkankualitas kombinasi cemouren dengan parameter nilai kalor berturut-turui 4.876 cal/g BBb,4.868 cal/g BTk, 4.783 cal/g UMB, 4.760 cal/g BTk, 4.477 cal/g UTk, 4.454 cal/g UB, 4.221 cal/g BTk, 4.162 cal/g BM, 4.156 cal/g MBb, dan 4.039 cal/g UM. Bila dibandingkan dengan standar nilai kalor yang dipersyaratkan secara nasional dan internasional masih belummemenuhi slandar.
Pengujian Karakteristik Fisik Jagung Bisi 2 untuk Mendesain Mesin Pemipil Jagung Portabel
Authors: Pomalingo Moh Fikri , Botutihe Sjahril , Ginting Agus Susanto 
Published: November 2018

Jagung merupakan salah satu potensi lokal utama di Gorontalo. Komoditi ini dibudidayakan di lahan datar dan lahan miring. Desa Botuwombato merupakan salah satu desa yang penghasil jagung terbesar di Gorontalo. salah satu varietas jagung yang banyak dibudidayakan di Gorontalo adalah Jagung Bisi 2. Salah satu permasalahan yang dihadapi yaitu belum adanya data karakteristik fisik buah jagung. Penelitian ini bertujuan untuk menganalisis karakteristik fisik buah dan biji jagung Bisi 2 sehingga dapat merancang alat dan mesin dan pertanian yang baik dan tepat dalam pengoperasioannya. Pengukuran massa jagung dilakukan dengan menggunakan timbagan analitik dan pengukuran dimensi menggunakan jangka sorong. Hasil penelitian menunjukkan bahwa rerata massa jagung mencapai 108.6 g. Berat rerata biji jagung yang berada pada ujung, tengah dan pangkal secara berurutan mencapai 19.4 g, 22.2 g, dan 24.2 g. Hasil penelitian juga membuktikan bahwa dimensi biji jagung terbesar berada pada pangkal buah, sedangkan diameter tongkol terkecil berada pada ujung tongkol dengan nilai 19.4 mm.