bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central nervous system relapse after allogeneic HCT in FLT3-mutated AML
Authors: Kouidri Khouloud , Acker Fabian , Toenges Rosa , Pfaff Saskia , Lindner Sarah , Riemann Julia , Werth Marek , Ajib Salem , Lang Fabian , Steffen Björn , Oellerich Thomas , Serve Hubert , Cremer Anjali , Bug Gesine 
Published: November 2024

AbstractCentral nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare, but prognostically extremely unfavorable and associated with very high mortality rates. Aim of our single-center study was to define risk factors for CNS relapse in patients with FLT3-mutated AML after allogeneic hematopoietic cell transplantation (HCT) and to determine the impact of pre-emptive or salvage therapy with FLT3-inhibitors (FLT3i) on occurrence of CNS relapse and overall prognosis. We analyzed 39 FLT3-mutated AML patients who were treated with intensive induction therapy and consecutively underwent HCT at our institution. We observed that the remission status before HCT was strongly associated with relapse probability. Notably, FLT3-mutated AML showed a high propensity for CNS relapse with a cumulative incidence of 50% (95% confidence interval [CI], 16–77) at 2 years in non-responders pre-HCT compared to 0% in responders (cause-specific hazard ratio, 24.5, 95% CI, 2.9-206.2; p = 0.003). This was not abrogated by pre-emptive or salvage therapy with FLT3i in first relapse. Targeted therapies prior to transplant, use of intrathecal chemoprophylaxis or closer monitoring may be considered in patients with FLT3-mutated AML with active disease prior to HCT in order to prevent CNS relapse.
Exact algorithms for continuous pricing with advanced discrete choice demand models
Authors: Haering Tom , Legault Robin , Torres Fabian , Ljubić Ivana , Bierlaire Michel 
Published: November 2024

AbstractWe present a spatial Branch and Bound and spatial Branch and Benders Decomposition approach together with the Breakpoint Exact Algorithm (BEA) to tackle the uncapacitated choice-based pricing problem (CPP) where demand is captured by a discrete choice model (DCM) based on the random utility principle. We leverage problem characteristics to reformulate the state-of-the-art simulation-based formulation of the CPP as a mixed-integer linear program (MILP) into a non-convex quadratically constrained quadratic program (QCQP), and then into a non-convex QCQP with linear objective (QCQP-L). We solve this reformulation with an efficient spatial Branch and Bound procedure utilizing the McCormick envelope for relaxations, which are then solved using Benders decomposition. We further exploit utility breakpoints to develop the BEA, which scales polynomially in the number of customers and draws, providing a fast option for low numbers of prices. Our methods are evaluated against solving the MILP, QCQP, or QCQP-L with GUROBI on a mixed logit (ML) parking space operator case study. We outspeed the MILP by several orders of magnitude when optimizing one or two prices and reduce computational time drastically for larger numbers of prices. When comparing to algorithms tailored for the CPP with ML demand specifically, our approaches significantly outperform the state of the art. Our methodology suits all choice-based optimization problems with linear-in-price utilities, given any DCM.
Do wild-caught fly larvae cooperatively forage?
Authors: Kuhar Rives , Williamson Madeline , Yee Peyton , Naik Guzel , Cursain Sean Michael , Condron Barry 
Published: November 2024

AbstractAnimals often form organized cooperative foraging groups, where individual members must adhere to specific rules to maintain cohesiveness. These groups face the challenge of managing potential intruders, who may or may not assist in foraging. In semi-liquid food environments, Drosophila larvae learn to synchronize their movements into clusters, which are thought to make feeding more efficient. Individuals who do not synchronize with the group are excluded from the cluster. Whether clustering behavior occurs in wild-caught larvae, and if so, the extent of their selectivity in group membership, remains unknown. Here, we show that clustering occurs across a number of fly species, and the capacity to join different clusters varies both between and within species. We collected and observed a larval cluster from rotting fruit in the field, yielding seven fly species. Subsequent tests for clustering on five lines from this collection and 20 other inbred wild-caught lines revealed that all species, except D. suzukii, exhibit clustering behavior. Each line demonstrates varying capacities to become members of different clusters. This study also indicates that there is high genetic variance in how individual lines cluster with each other that is not explained by cross species features. Additionally, combinations of wild species with lab benchmark strains give varied outcomes in resultant adult fitness. The ability to co-cluster varies between and within species boundaries. However, fly lines that cluster with another tend to impart fitness both to themselves and their host. Our findings demonstrate that multiple species of fly larvae can co-cluster. This behavior tends to confer mutual benefits to cluster members, suggesting significant ecological implications in Drosophila communities.
PD-L1 expression and characterization of its carrier macrophages in placentas with acute and specifically post-SARS-CoV-2 infection
Authors: Seefried Marina C. , Mittelberger Johanna , Franitza Manuela , Garrido Fabian , Wild Carl Mathis , Ditsch Nina , Protsepko Oleksii , Kuhn Christina , Dannecker Christian , Altevogt Peter , Jeschke Udo , Sammar Marei 
Published: November 2024

AbstractAt the beginning of the coronavirus disease 2019 (COVID-19) pandemic, uncertainties about the virus and its dangers during pregnancy caused great uncertainty and fear, especially among pregnant women. New data suggest an increased risk of obstetric complications, including maternal complications, preterm labor, intrauterine growth restriction, hypertensive disorders, stillbirths, gestational diabetes and risk, of neonatal developmental disorders. In addition, preeclampsia (PE)-like syndromes were also induced by severe COVID-19 infection. Therefore, the aim of this study was to investigate the expression of CD68 and CD163 and PD-L1 on placental tissues from acute covid patients, patients who survived a covid-19 infection and normal term controls that are known to be dysregulated in preeclampsia cases. We examined a total of 60 placentas from women that had given birth to female or male offspring in the University Hospital Augsburg. We investigated ten acute COVID-19 females, ten acute COVID-19 males, ten post-COVID-19 females, ten post-COVID-19 males, ten female term controls, and ten male term controls. Immunohistochemical staining against CD68, CD163, and PD-L1 was performed and the expression of the markers was evaluated with an immunoreactive score (percentage score). Identity of CD163- or PD-L1 expressing cells was analyzed by double immune fluorescence analyses. In opposite to PE, CD163 positive maternal macrophages are significantly upregulated in the decidua of male acute COVID-19 placentas. PD-L1 is significantly upregulated on male acute- and post-COVID-19 decidual immune cells and on male post-COVID-19 extravillous trophoblast cells. Surprisingly the observed effects are related to the fetal gender as they were not observed in female offsprings. Further investigation is necessary to analyze especially the imprinting effect of this infection.
Quantification of volcanic degassing and analysis of uncertainties using numerical modeling: the case of Stephanos crater (Nisyros Island, Greece)
Authors: Massaro Silvia , Tamburello Giancarlo , Bini Giulio , Costa Antonio , Stocchi Manuel , Tassi Franco , Biagi Rebecca , Vaselli Orlando , Chiodini Giovanni , Dioguardi Fabio , Selva Jacopo , Sandri Laura , Macedonio Giovanni , Caliro Stefano , Vougioukalakis Georges 
Published: November 2024

AbstractNisyros Island (Greece) is affected by widespread gas emissions from fumarolic fields located at the bottom of hydrothermal craters in the southern part of its caldera. This morphology and the current low gas fluxes make Nisyros an ideal site for testing the limits of physics-based gas dispersal models in confined and low-emission conditions. Here, we focused our attention on the local scale volcanic gas dispersion from the Stephanos hydrothermal crater. In April 2023, a 1-week survey was carried out to measure weather data, CO2 and H2S gas fluxes, air concentrations from portable gas stations, and chemical composition of fumarolic gases and to acquire thermal images of the crater floor. These data were used as inputs and boundary conditions for numerical simulations using a DISGAS-2.6.0 model in order to quantify the present-day volcanic degassing and its associated uncertainties, accounting for the meteorological variability. Model results are provided in terms of H2S probabilistic exceedance and persistence maps, showing gas concentrations within the crater that fall below the thresholds indicated for the occurrence of serious respiratory problems. Since DISGAS-2.6.0 does not account for chemical reactions, this study represents a good opportunity to discuss the methodological limits of simulating the dispersion of H2S which is challenging due to its rapid degradation and dilution in the atmosphere. In this regard, we also provided an empirical law of the H2S depletion in low-emission conditions that takes into account the uncertainties related to the field measurements.
Motivations-Apps und Gamification in der Abfallwirtschaft
Authors: Judmaier P. , Ladner S. , Taurer F. , Mynha C. , Mauthner B. , Salhofer S. , Beigl P. , Huber-Humer M. 
Published: November 2024

Zusammenfassung
Vor dem Hintergrund hoher biogener Anteile im Restmüll und zu verbessernder Bioabfallverwertung wurde das Projekt „KüKeN – Küchenküberl für energetische Nutzung“ gestartet, das neue Wege bei der Sammlung und kaskadischen Verwertung von biogenen Abfällen aus Haushalten erproben soll. Der Fokus liegt dabei auf dem Einsatz digitaler Medientechnologie zur Steigerung der Motivation und zur Verbesserung der Sammelqualität. Als Grundlage für Entwicklungen im Rahmen dieses Projekts werden der Hintergrund zur Gamification, der Stand der Sensorik in Hinblick auf die technische Umsetzung des Küchenküberls sowie der Stand der Technik bei abfallwirtschaftlichen Apps dargestellt. Die Konzeption des interaktiven Küchenküberls in Kombination mit einer Motivations-App basiert auf einem nutzer:innenzentrierten Designprozess, wobei Nudging als Ansatz für die Trenn- und Sammelmotivation zur Anwendung kommt. Hauptzielgruppe der KüKeN-App sind Kinder und Jugendliche, die als Multiplikator:innen Kenntnisse und Engagement für das Thema Abfalltrennung in ihrem Umfeld verbreiten. Auf Basis von User- und Stakeholder-Workshops wurde die KüKeN-App mit drei Komponenten – ein ChatBot für Information, ein Spiel zur Wissensvermittlung sowie ein Spiel zur Aufrechterhaltung der Motivation – entwickelt. Nach der Vorstellung des Ergebnisses der Smartphone-Applikation gibt der Artikel einen Ausblick auf den bevorstehenden Einsatz der App in der Testregion.
Development and validation of a claims-based algorithm to identify incidents and determine the progression phases of gastric cancer cases in Japan
Authors: Inoue Takahiro , Agatsuma Nobukazu , Utsumi Takahiro , Tanaka Yukari , Nishikawa Yoshitaka , Horimatsu Takahiro , Shimizu Takahiro , Nikaido Mitsuhiro , Nakanishi Yuki , Hoshino Nobuaki , Takahashi Yoshimitsu , Nakayama Takeo , Seno Hiroshi 
Published: November 2024

Abstract

Background
Although health insurance claims data can address questions that clinical trials cannot answer, the uncertainty of disease names and the absence of stage information hinder their use in gastric cancer (GC) research. This study aimed to develop and validate a claims-based algorithm to identify and determine the progression phases of incident GC cases in Japan.

Methods
The gold standard for validation in this retrospective observational study was medical records of patients with incident GC who underwent specific treatments, defined by the claim codes associated with GC treatment. The algorithm was developed and refined using a cohort from two large tertiary care medical centers (April–September 2017 and April–September 2019) and subsequently validated using two independent cohorts: one from different periods (October 2017–March 2019 and October 2019–March 2021) and the other from a different institution (a community hospital). The algorithm identified incident cases based on a combination of the International Classification of Diseases, 10th Revision diagnosis codes for GC (C160-169), and claim codes for specific treatments, classifying them into endoscopic, surgical, and palliative groups. Positive predictive value (PPV), sensitivity of incident case identification, and diagnostic accuracy of progression phase determination were evaluated.

Results
The developed algorithm achieved PPVs of 90.0% (1119/1244) and 95.9% (94/98), sensitivities of 98.0% (1119/1142) and 98.9% (94/95) for incident case identification, with diagnostic accuracies of 94.1% (1053/1119) and 93.6% (88/94) for progression phase determination in the two validation cohorts, respectively.

Conclusions
This validated claims-based algorithm could advance real-world GC research and assist in decision-making regarding GC treatment.
Shear Behavior and Acoustic Emission Characteristics of Propped Rough Fractures
Authors: Zhang Qi , Su Boyang , Chen Guoxu , Luo Jin , Zhang Jiale , Zhao Qi , Ni Yi-Qing 
Published: November 2024

Abstract
Shearing stimulation with proppant is widely used in geothermal and hydrocarbon reservoirs. However, the shear behavior associated with proppant-proppant and proppant-fracture interactions has not been clearly elaborated. This paper investigates surface damage and the interactions between proppant and surface roughness through direct shear tests with acoustic emission (AE) monitoring. The AE events show distinct spatial and temporal distribution patterns under the influence of proppant. The small magnitude AE events, representing proppant slipping and crushing, start to occur in large areas from the beginning of the shear deformation, and the large magnitude AE events occur mostly at the peak and during the residual phase and are concentrated on asperities. Crushed proppant grains and asperities form a gouge layer that prevents further damage to the fracture surface, reduces shear dilation and promotes aseismic creep. Fine proppant grains tend to remain intact, while the coarse proppant grains tend to be crushed. Our results suggest that acoustic emission characteristics can be used to infer different stages of shear behavior of propped fractures. These findings enhance our understanding of the shear behavior of propped fractures and provide evidence for monitoring their conditions using seismic signals.
Effect of powder air polishing and ultrasonic scaling on the marginal and internal interface (tooth-veneer) of ceramic veneers: an in vitro study
Authors: Fuchs Florian , Mayer Laura Antonia , Unterschütz Lena , Ziebolz Dirk , Oberueck Nadia , Schulz‑Kornas Ellen , Hahnel Sebastian , Koenig Andreas 
Published: November 2024

Abstract
Objectives
This study investigated the influence of prophylactic treatments and thermocycling on the marginal and internal veneering interface (tooth-veneer) as well as on the surface texture of ceramic veneers.

Materials and methods
A total of 32 extracted human premolars were restored with veneers made of lithium disilicate (LDS) or zirconia-reinforced lithium silicate (ZLS). An artificial aging of the specimens was conducted via five cycles of both thermocycling (5/55°C) and prophylactic treatment (powder air polishing or ultrasonic scaling). Changes in the marginal interface and in the surface texture were examined using confocal laser scanning microscopy. The internal interface and the microstructure were investigated using micro X-ray computed tomography.

Results
Artificial aging resulted in a deepening of the marginal interface across all groups (mean height: 4.51–15.74 μm, maximum height: 10.42–22.71 μm, cross-section: 256.68–1525.84 μm², regardless of the veneer material or prophylaxis method. No change in surface texture was observed. The internal interface exhibited defects for all groups after artificial aging. ZLS showed cracks in five out of eight veneers after exposure to ultrasonic scaling and thermocycling.

Conclusion
Ceramic veneers exhibited a high resistance to prophylactic measures in terms of surface durability, but a deepening of the marginal interface should be taken into account. With regard to the formation of cracks within the material, the use of ultrasonic scaling is not recommended for ZLS veneers.

Clinical relevance
The influence of artificial aging, including prophylactic treatments, plays a critical role in assessing longevity for veneers in defect-oriented and esthetic dentistry.
Effects of aggregate crushing and strain rate on fracture in compressive concrete with a DEM-based breakage model
Authors: Nitka Michal , Tejchman Jacek 
Published: November 2024

Abstract
This study looked at how breakable aggregates affected the mesoscopic dynamic behavior of concrete in the uniaxial compression condition. In-depth dynamic two-dimensional (2D) studies were conducted to examine the impact of aggregate crushing and strain rate on concrete’s dynamic strength and fracture patterns. Using a DEM-based breakage model, concrete was simulated as a four-phase material consisting of aggregate, mortar, ITZs, and macropores. The concrete mesostructure was obtained from laboratory micro-CT tests. Collections of spherical particles were used to imitate aggregate breakage of different sizes and shapes by enabling intra-granular fracturing between them. The mortar was described in terms of unbreakable spheres with different diameters. Compared to the mortar, the aggregate strength was always stronger. A qualitative consistency was achieved between the DEM results and the available experimental data. Concrete’s dynamic compressive strength rose significantly with strain rate and just somewhat with aggregate strength. The fracture process was impacted considerably by aggregate crushing and strain rate. The number of broken contacts grew with an increase in strain rate and a decrease in aggregate strength.
Bumblebee social learning outcomes correlate with their flower-facing behaviour
Authors: Lu Yuyi , Zhuo Zhenwei , Roper Mark , Chittka Lars , Solvi Cwyn , Peng Fei , Zhou Ying 
Published: November 2024

Abstract
Previous studies suggest that social learning in bumblebees can occur through second-order conditioning, with conspecifics functioning as first-order reinforcers. However, the behavioural mechanisms underlying bumblebees’ acquisition of socially learned associations remain largely unexplored. Investigating these mechanisms requires detailed quantification and analysis of the observation process. Here we designed a new 2D paradigm suitable for simple top-down high-speed video recording and analysed bumblebees’ observational learning process using a deep-learning-based pose-estimation framework. Two groups of bumblebees observed live conspecifics foraging from either blue or yellow flowers during a single foraging bout, and were subsequently tested for their socially learned colour preferences. Both groups successfully learned the colour indicated by the demonstrators and spent more time facing rewarding flowers—whether occupied by demonstrators or not—compared to non-rewarding flowers. While both groups showed a negative correlation between time spent facing non-rewarding flowers and learning outcomes, the observer bees in the blue group benefited from time spent facing occupied rewarding flowers, whereas the yellow group showed that time facing unoccupied rewarding flowers by the observer bees positively correlated with their learning outcomes. These results suggest that socially influenced colour preferences are shaped by the interplay of different types of observations rather than merely by observing a conspecific at a single colour. Together, these findings provide direct evidence of the dynamical viewing process of observer bees during social observation, opening up new opportunities for exploring the details of more complex social learning in bumblebees and other insects.
An Equivalence Between Two Models of $$\infty $$-Categories of Enriched Presheaves
Authors: Heine Hadrian 
Published: November 2024

Abstract
Let

$${{\mathcal {O}}}\rightarrow {\text {BM}}$$

O
→
BM

be a

$${\text {BM}}$$

BM

-operad that exhibits an

$$\infty $$

∞

-category

$${{\mathcal {D}}}$$

D

as weakly bitensored over non-symmetric

$$\infty $$

∞

-operads

$${{\mathcal {V}}}\rightarrow \text {Ass }, {{\mathcal {W}}}\rightarrow \text {Ass }$$

V
→
Ass

,
W
→
Ass

and

$${{\mathcal {C}}}$$

C

a

$${{\mathcal {V}}}$$

V

-enriched

$$\infty $$

∞

-precategory. We construct an equivalence

$$\begin{aligned} \text {Fun}_{\text {Hin}}^{{\mathcal {V}}}({{\mathcal {C}}},{{\mathcal {D}}}) \simeq \text {Fun}^{{\mathcal {V}}}({{\mathcal {C}}},{{\mathcal {D}}}) \end{aligned}$$

Fun

Hin

V

(
C
,
D
)

≃

Fun
V

(
C
,
D
)

of

$$\infty $$

∞

-categories weakly right tensored over

$${{\mathcal {W}}}$$

W

between Hinich’s construction of

$${{\mathcal {V}}}$$

V

-enriched functors of Hinich (Adv Math 367:107129, 2020) and our construction of

$${{\mathcal {V}}}$$

V

-enriched functors of Heine (Adv Math 417:108941, 2023).
Impact of CCND1 amplification on the prognosis of hormone receptor–positive, HER2-negative breast cancer patients—correlation of clinical and pathological markers
Authors: Hanf Dorothea , Fasching Peter , Gass Paul , Matthias W. Beckmann  , Hack Carolin C. , Heindl Felix , Lothar Häberle  , John Nelson , Erber Ramona , Press Michael F. , Rübner Matthias , Pöschke Patrik 
Published: November 2024

Abstract

Purpose
The cyclin D1 gene (CCND1) encodes a key cell-cycle regulatory protein. Resistance to endocrine therapy is reportedly observed more often in patients with CCND1-amplified tumors. CCND1 amplification is known to be a driving event in breast cancer, but contradictory findings are reported for its association with prognosis. This study therefore investigated the prognostic value of CCND1 amplification in hormone receptor (HR)-positive breast cancer patients.

Methods
A cohort of 894 unselected breast cancer patients from the Bavarian Breast Cancer Cases and Controls (BBCC) study was included. The CCND1 amplification rate was evaluated in tissue microarrays using fluorescence in situ hybridization. A CCND1/CEP11 ratio ≥ 2.0 was considered amplified. Statistical analysis was conducted on cases with ratios based on a range of 20–100 nuclei analyzed per case. A univariable Cox regression model was fitted with disease-free survival (DFS) and overall survival (OS).

Results

CCND1 gene status was assessable in 511 patients. The CCND1 amplification rate was 12.9% (66 patients). Most patients with CCND1 amplification had luminal B-Like—(51.5%, n = 34) or luminal A-Like tumors (25.8%, n = 17), 13 patients with HER2-positive disease (19.7%) and only two patients had triple-negative tumors (3.0%). Survival analysis, focused on HR-positive, HER2-negative patients, showed no statistically significant differences in the DFS and OS with and without CCND1 amplification (P = 0.20 and 0.14, respectively, in the unadjusted analysis).

Conclusions

CCND1 amplification is a recurring event in breast cancer, occurring most frequently in luminal B-like and HER2-amplified subtypes. A trend toward less favorable outcomes was observed among CCND1-amplified HR-positive, HER2-negative tumors.