bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cumulative Dehumanization in Everyday Policing: The Psychological, Affective, and Material Consequences of Discretionary Arrests
Authors: Bustamante Priscilla , Jashnani Gaurav , Stoudt Brett G. 
Published: September 2019

AbstractAmid aggressive surveillance and policing practices, Black Lives Matter has appeared—a social movement whose very name highlights collective resistance to pervasive dehumanization. Psychological studies find the persistent dehumanization of people of color and endorsement of legitimated violence against those dehumanized. As part of broken windows policing, people of color also disproportionately experience discretionary arrests, or charges for low‐level, nonviolent offenses legally recognized as noncriminal. Accordingly, drawing upon data from over 200 interviews and surveys, we report on New Yorkers’ experiences of dehumanization during discretionary arrests. In doing so, we introduce a new conceptual framework called “cumulative dehumanization,” to illuminate an ongoing state‐sanctioned, racialized dehumanization that is fundamentally cumulative, both temporally and spatially. We conceptualizecumulative dehumanizationas: (a) an accumulation of systemic dehumanizing moments, experienced as an active condition of becoming; (b) a weathering of the racialized affective body, generating various modes of community dispossession; (c) a product and (re)producer of the material and ideological mechanisms upholding racial capitalism; and (d) a complementary accumulation of individual and collective resistance. Attending to amplified processes and consequences within the uneven power dynamics of daily policing practices, we connect everyday, state‐sanctioned dehumanization to cognitive, embodied, psychological, social, material, ideological, and political circuits.
Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease
Authors: Goel G , Daveson A J M , Hooi C E , Tye-Din J A , Wang S , Szymczak E , Williams L J , Dzuris J L , Neff K M , Truitt K E , Anderson R P 
Published: September 2019

Summary
Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten in coeliac disease. The aim of this study was to establish a quantitative hierarchy of serum cytokines and their relation to symptoms in patients with coeliac disease during gluten-mediated cytokine release reactions. Sera were analyzed from coeliac disease patients on a gluten free-diet (n = 25) and from a parallel cohort of healthy volunteers (n = 25) who underwent an unmasked gluten challenge. Sera were collected at baseline and 2, 4 and 6 h after consuming 10 g vital wheat gluten flour; 187 cytokines were assessed. Confirmatory analyses were performed by high-sensitivity electrochemiluminescence immunoassay. Cytokine elevations were correlated with symptoms. Cytokine release following gluten challenge in coeliac disease patients included significant elevations of IL-2, chemokine (C-C motif) ligand 20 (CCL20), IL-6, chemokine (C-X-C motif) ligand (CXCL)9, CXCL8, interferon (IFN)-γ, IL-10, IL-22, IL-17A, tumour necrosis factor (TNF)-α, CCL2 and amphiregulin. IL-2 and IL-17A were earliest to rise. Peak levels of cytokines were generally at 4 h. IL-2 increased most (median 57-fold), then CCL20 (median 10-fold). Cytokine changes were strongly correlated with one another, and the most severely symptomatic patients had the highest elevations. Early elevations of IL-2, IL-17A, IL-22 and IFN-γ after gluten in patients with coeliac disease implicates rapidly activated T cells as their probable source. Cytokine release after gluten could aid in monitoring experimental treatments and support diagnosis.
Clinical results of ab interno trabeculotomy using the trabectome in patients with uveitic glaucoma
Authors: Swamy Ramya , Francis Brian A. , Akil Handan , Yelenskiy Aleksandr , Francis Brandon A. , Chopra Vikas , Huang Alex 
Published: September 2019

AbstractImportanceTo evaluate the safety and efficacy of ab interno trabeculotomy (AIT) (trabecular ablation) with the trabectome in patients with uveitic glaucoma.BackgroundTraditional glaucoma filtration surgeries in the uveitic patient population come with a higher risk of complications such as failure and hypotony.DesignRetrospective observational cohort study.ParticipantsAll patients diagnosed with uveitic glaucoma were included in this study. Patients were excluded if they have less than 12 months of follow‐up.MethodsAll patients who received AIT alone or combined with phacoemulsification.Main Outcome MeasuresMajor outcomes include intraocular pressure (IOP), number of glaucoma medications and secondary glaucoma surgery, if any. Kaplan‐Meier method was used for survival analysis and success was defined as IOP ≤21 mmHg, at least 20% IOP reduction from baseline for any two consecutive visits after 3 months, no additional glaucoma medications, and no secondary glaucoma surgery.ResultsA total of 45 eyes, 45 patients, with an average age of 52 years were included in the study. The majority were Japanese (40%) and underwent AIT alone (71%). IOP was reduced from 29.2 ± 8.0 to 16.7 ± 4.6 mmHg at 12 months (P < .01*), while the number of glaucoma medications was reduced from 4.0 ± 1.0 to 2.5 ± 1.6 (P < .01*). Survival rate at 12 months was 91%. Six cases required secondary glaucoma surgery and no other serious complication were reported.Conclusions and RelevanceThe trabectome AIT procedure appears to be effective in reducing IOP in uveitic glaucoma patients. Although no statistically significant difference was found in the number of glaucoma medications, a decreasing trend was found.
What do bilingual infants actually hear? Evaluating measures of language input to bilingual‐learning 10‐month‐olds
Authors: Orena Adriel John , Byers‐Heinlein Krista , Polka Linda 
Published: September 2019

AbstractExamining how bilingual infants experience their dual language input is important for understanding bilingual language acquisition. To assess these language experiences, researchers typically conduct language interviews with caregivers. However, little is known about the reliability of these parent reports in describing how bilingual children actually experience dual language input. Here, we explored the quantitative nature of dual language input to bilingual infants. Furthermore, we described some of the heterogeneity of bilingual exposure in a sample of French–English bilingual families. Participants were 21 families with a 10‐month‐old infant residing in Montréal, Canada. First, we conducted language interviews with the caregivers. Then, each family completed three full‐day recordings at home using the Language Environment Analysis recording system. Results showed that children’s proportion exposure to each language was consistent across the two measurement approaches, indicating that parent reports are reliable for assessing a bilingual child’s language experiences. Further exploratory analyses revealed three unique findings: (a) there can be considerable variability in the absolute amount of input among infants hearing the same proportion of input, (b) infants can hear different proportions of language input when considering infant‐directed versus overheard speech, (c) proportion of language input can vary by day, depending on who is caring for the infant. We conclude that collecting naturalistic recordings is complementary to parent‐report measures for assessing infant’s language experiences and for establishing bilingual profiles.
Irrelevant‐action imitation is short‐term and contextual: Evidence from two under‐studied populations
Authors: Kline Michelle A. , Gervais Matthew M. , Moya Cristina , Boyd Robert T. 
Published: September 2019

AbstractAcross the lifespan and across populations, humans ‘overimitate’ causally unnecessary behaviors. Such irrelevant‐action imitation facilitates faithful cultural transmission, but its immediate benefits to the imitator are controversial. Over short time scales, irrelevant‐action imitation may bootstrap artifact exploration or interpersonal affiliation, and over longer time scales it may facilitate acquisition of either causal models or social conventions. To investigate these putative functions, we recruited community samples from two under‐studied populations: Yasawa, Fiji, and Huatasani, Peru. We use a two‐action puzzle box: first after a video demonstration, and again one month later. Treating age as a continuous variable, we reveal divergent developmental trajectories across sites. Yasawans (44 adults, M = 39.9 years, 23 women; 42 children, M = 9.8 years, 26 girls) resemble documented patterns, with irrelevant‐action imitation increasing across childhood and plateauing in adulthood. In contrast, Huatasaneños (48 adults, M = 37.6 years, 33 women; 47 children, M = 9.3 years, 13 girls) evince a parabolic trajectory: adults at the site show the lowest irrelevant‐action imitation of any demographic set in our sample. In addition, all age sets in both populations reduce their irrelevant actions at Time 2, but do not reduce their relevant‐action imitation or goal attainment. Taken together, and considering the local cultural contexts, our results suggest that irrelevant‐action imitation serves a short‐term function and is sensitive to the social context of the demonstration.
Young children, adolescent girls and women with type 1 diabetes are more overweight and obese than reference populations, and this is associated with increased cardiovascular risk factors
Authors: Marlow A. L. , Rowe C. W. , Anderson D. , Wynne K. , King B. R. , Howley P. , Smart C. E. 
Published: September 2019

AbstractAimOverweight and obesity are frequently reported in young persons with type 1 diabetes, however its relative magnitude in comparison to the general population is not well understood. This study compared the prevalence of overweight and obesity in young persons with type 1 diabetes to a reference population and explored possible associated factors, including gender, age, HbA1c, insulin regimen, age at diagnosis, diabetes duration, socio‐economic status and cardiovascular disease risk factors.MethodsA cross‐sectional review was undertaken of data collected from youth (3–17 years) in 2016 and young adults (18–30 years) in 2015 with a diagnosis of type 1 diabetes for > 3 months attending diabetes centres in Newcastle, Australia. Rates of overweight and obesity were compared with matched population survey results.ResultsData from 308 youth and 283 young adults were included. In girls, significantly higher prevalence of overweight and obesity were seen in the 5–8 (43% vs. 18%), 13–16 (41% vs. 27%), 18–24 (46% vs. 34%) and 25–30 (60% vs. 43%) years age groups; whereas in boys increased prevalence was observed in the 5–8 years age group only (41% vs. 18%). Rates of overweight and obesity increased with age across sexes. In youth, BMI standard deviation score was correlated with socio‐economic status, insulin regimen, blood pressure and blood lipids (P < 0.05). In adults, BMI was positively associated with blood pressure, and longer diabetes duration (P < 0.02).ConclusionsOverweight and obesity are over‐represented in young persons with type 1 diabetes, particularly girls. As overweight is associated with other cardiovascular disease markers early intervention is paramount.
Early detection of cardiotoxicity by 3D speckle tracking imaging of area strain in breast cancer patients receiving chemotherapy
Authors: Chen Jianqiong , Wang Ling , Wu Fang‐Fang , Sun Guoping 
Published: September 2019

AbstractEighty‐three breast cancer patients who underwent six cycles of EC chemotherapy regimen (epirubicin + cyclophosphamide) without symptoms and signs of heart disease were enrolled in the study. Three‐dimensional speckle tracking imaging technique (3D‐STI) was used to measure left ventricular global area strain (GAS), overall annular strain (GCS), overall longitudinal strain (GLS), and overall radial strain (GRS). Meanwhile, serum troponin T (Hs‐cTnT) was measured. The clinical value of each index on cardiotoxicity after chemotherapy was analyzed using the receiver operating characteristic (ROC) curve. Hs‐cTnT increased from the early stage to the end during chemotherapy, but it was still in the normal range. During the mid‐chemotherapy and the end‐chemotherapy, GAS, GLS, GCS, and E/A significantly reduced, while the changes in LVESV, LVEDV, LVEF, and GRS were not significant after chemotherapy. Pearson correlation analysis showed a significant negative correlation between GAS and anthracycline doses (r = −.772, P < .01); GAS and Hs‐cTnT were significantly negatively correlated (P < .05). The area under the curve (AUC) of GAS, GLS, GCS, and GRS are 0.815, 0.683, 0.645, and 0.585, respectively. A GAS of −31.5% was used as the cutoff value for diagnosing left ventricular systolic dysfunction after receiving chemotherapy. The sensitivity of the previous parameters was 81.9%, and the specificity was 80.3%. Interobserver consistency analysis showed that 3D‐STI strain parameter measurement has good repeatability. GAS has greater value in predicting early myocardial damage after anthracycline chemotherapy.
Interactions among body size, trophic level, and dispersal traits predict beetle detectability and occurrence responses to fire
Authors: Driscoll Don A. , Smith Annabel L. , Blight Samantha , Sellar Ian 
Published: September 2019

1. Testing the extent to which traits act alone or in combination with other traits to influence responses to fire informs the trade‐off between increased generalisation using single traits and increased predictive power using interactions. This study investigated the following question: do four traits (body size, trophic group, dispersal ability, and stratum of the ecosystem), alone or in combination, best explain changes in beetle occurrence with time since fire?2. The data from 4 years and 15 independent fires in southern Australia were analysed using generalised linear mixed models. The study also assessed whether detectability depends on time since fire using multi‐year detection models, because detectability has the potential to confound occurrence patterns.3. The best model included the three‐way combination of size, flight, and trophic level interacting with time since fire and with year. The relationship between detectability and time since fire was similar to the occurrence relationship in six of the 10 trait–combination groups, with flightless species generally showing reduced detection probability as time since fire increased. Detectability did not confound occurrence responses for four trait groups, with three increasing with time since fire and one decreasing.4. Generalisation using main effects of traits risks oversimplifying animal responses to fire, because combinations of traits influence the direction and magnitude of the response. Also, taking detectability into account is critical to correctly interpretating occupancy data. Three‐way trait combinations that differ by just one trait, particularly dispersal ability, can result in either negligible effects of disturbance on detectability or strong effects that influence observed occurrence.
Elevated zinc transporter ZnT3 in the dentate gyrus of mast cell‐deficient mice
Authors: Wiqas Amen , LeSauter Joseph , Taub Alana , Austin Rachel Narehood , Silver Rae 
Published: September 2019

AbstractZinc is important in neurogenesis, but excessive levels can cause apoptosis and other pathologies leading to cognitive impairments. Mast cells are present in many brain regions including the hippocampus, an area rich in vesicular zinc. Mast cells contain zinc‐rich granules and a well‐developed mechanism for uptake of zinc ions; both features point to the potential for a role in zinc homeostasis. Prior work using the Timm stain supported this hypothesis, as increased labile zinc was detected in the hippocampus of mast cell‐deficient mice compared to wild‐type mice while no differences in total zinc were found between the two genotypes in the whole brain or other tissues. The current report further examines differences in zinc homeostasis between wild‐type and mast cell‐deficient mice by exploring the zinc transporter ZnT3, which transports labile zinc into synaptic vesicles. The first study used immunocytochemistry to localize ZnT3 within the mossy fibre layer of the hippocampus to determine whether there was differential expression of ZnT3 in wild‐type versus mast cell‐deficient mice. The second study used inductively coupled plasma mass spectrometry (ICP‐MS) to determine total zinc content in the whole dentate gyrus of the two genotypes. The immunocytochemical results indicate that there are higher levels of ZnT3 localized to the mossy fibre layer of the dentate gyrus of mast cell‐deficient mice than in wild‐type mice. The ICP‐MS data reveal no differences in total zinc in dentate gyrus as a whole. The results are consistent with the hypothesis that mast cells participate in zinc homeostasis at the level of synaptic vesicles.
Large‐scale network dysfunction in vascular cognitive disorder supports connectional diaschisis in advanced arteriosclerosis
Authors: Meng D. , Hosseini A. A. , Simpson R. J. , Welton T. , Dineen R. A. , Auer D. P. 
Published: September 2019

Background and purposeThe interrelation of cognitive performance, cerebrovascular damage and brain functional connectivity (FC) in advanced arteriosclerosis remains unclear. Our aim was to investigate the associations between FC, white matter damage and cognitive impairment in carotid artery disease.MethodsSeventy‐one participants with a recent cerebrovascular event and with written informed consent underwent resting‐state functional magnetic resonance imaging and the Addenbrooke's Cognitive Examination – Revised (ACE‐R). Network and inter‐hemispheric FC metrics were compared between cognitively normal and impaired subjects, and interrelated with cognition. In order to explore the nature of FC changes, their associations with microstructural damage of related white matter tracts and cognitive performance were investigated, followed by mediation analysis.ResultsParticipants with global cognitive impairment showed reduced FC compared to the cognitively intact subjects within the central executive network (CEN), and between hemispheres. Patients with executive dysfunction had decreased CEN FC whilst patients with memory loss demonstrated low FC in both the CEN and the default mode network (DMN). Global performance correlated with connectivity metrics of the CEN hub with DMN nodes, and between hemispheres. Cingulum mean diffusivity (MD) was negatively correlated with ACE‐R and CEN–DMN FC. The cingulum MD–cognition association was partially mediated by CEN–DMN FC.ConclusionsLong‐range functional disconnection of the CEN with DMN nodes is the main feature of cognitive impairment in elderly subjects with symptomatic carotid artery disease. Our findings provide further support for the connectional diaschisis concept of vascular cognitive disorder, and highlight a mediation role of functional disconnection to explain associations between microstructural white matter tract damage and cognitive impairment.
Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed
Authors: Bellone R. R. , Ocampo N. R. , Hughes S. S. , Le V. , Arthur R. , Finno C. J. , Penedo M. C. T. 
Published: September 2019

SummaryBackgroundCatastrophic fractures are among the most common cause of fatalities in racehorses. Several factors, including genetics, likely contribute to increased risk for fatal injuries. A variant in the procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase1 gene (PLOD1 c.2032G>A) was shown to cause Warmblood fragile foal syndrome type 1 (WFFS), a fatal recessive defect of the connective tissue. Screening of multiple horse breeds identified the presence of the WFFS allele in the Thoroughbred. PLOD1 is involved in cross‐linking of collagen fibrils and thus could potentially increase the risk of catastrophic breakdown.ObjectivesEstimate the frequency of the WFFS allele (PLOD1 c.2032G>A) and determine if it is a risk factor for catastrophic breakdown in the Thoroughbred.Study designCase–control genetic study.MethodsGenomic DNA from hair and/or tissue samples was genotyped for the WFFS allele. Fisher’s Exact tests were performed to compare allele and carrier frequencies between the case cohort (catastrophic breakdown, n = 22) and several cohorts with no record of injury (n = 138 raced/trained at same track and season and n = 185 older than 7 years and raced during same season), nonracers (n = 92), and a random sample without consideration for racing history (n = 279).ResultsThe frequency of the PLOD1 c.2032G>A variant in the Thoroughbred breed is low (1.2%). Seventeen of 716 Thoroughbreds tested were carriers (2.4%) and no WFFS homozygotes were detected. Only one catastrophic breakdown case carried the WFFS allele. No statistically significant difference in allele or carrier frequency was identified between case and control cohorts (P>0.05 in all comparisons performed).Main limitationsThis study evaluated cases from one single track.ConclusionsThis study demonstrated that the PLOD1 c.2032G>A associated with WFFS is present at very low frequency in Thoroughbreds and is not a genetic risk factor for catastrophic breakdown.
Mispriced index option portfolios
Authors: Constantinides George M. , Czerwonko Michal , Perrakis Stylianos 
Published: September 2019

AbstractIn model‐free out‐of‐sample tests, we find that the optimal portfolio of a utility maximizing investor trading in the S&P500 Index, cash, and index options bought at ask and written at bid prices stochastically dominates the optimal portfolio without options and yields returns with higher mean and lower volatility in most months from 1990 to 2013. Unlike earlier claims of overpriced puts, our portfolios include mostly short calls and are particularly profitable when maturity is short and volatility is high. Similar results are obtained with the CAC and DAX indices. Neither priced factors nor a nonmonotonic stochastic discount factor explains the excess returns.
Financing seasonal demand
Authors: Fairhurst Douglas (DJ) 
Published: September 2019

AbstractThis paper identifies seasonal firms and their peak seasons to provide empirical evidence of the approach these firms take to finance seasonal operations. The seasonal use of funds, which builds before seasonal revenue, is largely financed with transitory sources of credit, such as credit lines, trade credit, and commercial paper. Permanent financing is used only moderately to meet seasonal needs. However, both weak credit market conditions and firm‐level financial constraints limit the ability of seasonal firms to use debt as transitory financing. These frictions result in a partial shift to permanent financing but reduce the seasonal use of funds overall.