bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schwangerschaftsbegleitende Behandlung bei hereditärer Dysfibrinogenämie nach wiederkehrendem Schwangerschaftsverlust
Authors: Zimmermann Robert , Peisl Julia , Geisen Christoph , Körber Stephanie , Achenbach Susanne , Hackstein Holger 
Published: March 2019

ZusammenfassungEine Dysfibrinogenämie kann zu Blutungen oder Thrombosen sowie zu Geburtskomplikationen führen. Letztere beinhalten frühzeitige Schwangerschaftsverluste, Blutungen, vorzeitige Plazentaablösung und Thrombosen. Es gibt nur wenige Fallberichte mit Behandlungsempfehlungen für Schwangerschaften bei betroffenen Frauen. Wir berichten über eine inzwischen 34-jährige Frau, bei der es zwischen 2013 und 2015 zu 4 aufeinanderfolgenden Frühaborten kam. Bei der Vorstellung in unserer Ambulanz berichtete die Patientin von einer Neigung zu Blutergüssen, aber keine weiteren Blutungen und keine thromboembolischen Ereignisse. Laboruntersuchungen ergaben einen verminderten Quick-Wert, eine verlängerte Thrombinzeit, eine stark verlängerte Reptilasezeit und Fibrinogenkonzentrationen von 67 mg/dl (Clauss-Methode) und 387 mg/dl (Immunturbidimetrie). Bei der Patientin wurde eine Dysfibrinogenämie diagnostiziert. Die molekularbiologische Untersuchung ergab die Mutation c.103C>T (p.Arg35Cys) im Exon 2 des FGA-Gens (Synonym Aα 16Arg→Cys-Substitution). Während der 5. und 6. Schwangerschaft wurde die Patientin mit einem niedermolekularen Heparin unter Verwendung der empfohlenen Prophylaxedosis für erhöhtes Thromboserisiko behandelt. Gleichzeitig erhielt die Patientin 3 × wöchentlich Fibrinogenkonzentrat (3 × 2 g pro Woche). Darunter verliefen beide Schwangerschaften ereignislos. Schwangerschaftskomplikationen wurden in vielen Fällen berichtet, wenn der funktionell aktive Fibrinogenspiegel unter 0,6 g/l lag (Clauss-Methode). Nach der erstmaligen Feststellung einer Dysfibrinogenämie bei einer Frau ohne offensichtliche Blutungsneigung und ohne thromboembolische Ereignisse in der Anamnese erscheint aus unserer Sicht die empfehlenswerte Vorgehensweise, Fibrinogen zu substituieren und gleichzeitig niedermolekulare Heparine zu geben, um sowohl Blutungen als auch Thrombosen und Schwangerschaftsverluste zu verhindern.
Whole-Body MRI in Children and Adolescents – S1 Guideline
Authors: Schaefer Jürgen F. , Berthold Lars Daniel , Hahn Gabriele , von Kalle Thekla , Moritz Jörg Detlev , Schröder Cornelia , Stegmann Joachim , Steinborn Marc , Weidemann Jürgen , Wunsch Rainer , Mentzel Hans-Joachim 
Published: March 2019

Whole-body MRI is an imaging method that uses advanced modern MRI equipment to provide high-resolution images of the entire body. The goal of these guidelines is to specify the indications for which whole-body MRI can be recommended in children and adolescents and to describe the necessary technical requirements.
Citation Format
Anwendbarkeit neonataler Schmerzscores in Abhängigkeit von Ausbildungsstand und Berufserfahrung in der Kinderpflege
Authors: Kaiser Johanna , Laffolie Jan , Kappesser Judith , Ehrhardt Harald , Utsch Boris , Hermann Christiane 
Published: March 2019

Zusammenfassung
Hintergrund Neben der Schmerzprävention kommt der Schmerzbestimmung und -therapie durch Pflegekräfte eine wichtige Rolle im Schmerzmanagement in der Neonatologie zu. Durch einen Vergleich einer Gruppe weniger erfahrener Pflegeschüler mit erfahrenen Pflegekräften in der Nutzung beider Methoden unter standardisierten Bedingungen soll getestet werden, ob der Ausbildungsstand und die Erfahrung der Pflegekraft allgemein sowie speziell mit Neugeborenen die Nutzung scorebasierter oder subjektiver Diagnosehilfsmittel beeinflusst.
Methodik Zur Datenerhebung scorten 44 Pflegeschüler der Krankenpflegeschule und 35 Personen des Pflegepersonals zweier Universitätskliniken den Premature Infant Pain Profile Score (PIPP) – ein 7 dimensionaler Schmerzscore – für 10 Videosequenzen von schmerzhaften Prozeduren an Früh- und Neugeborenen. Die subjektive Einschätzung des Schmerzes wurde durch eine zusätzliche Numerische Rating Skala (NRS) verzeichnet.
Ergebnisse Im Gegensatz zur Anwendung von eindimensionalen Schmerzmessinstrumenten lassen sich bei der Anwendung des PIPP keine Unterschiede zwischen den Ausbildungsständen „Schüler“ und „erfahrene Pflegekräfte“ entdecken. Auch die Berufserfahrung mit Neugeborenen hat scheinbar keinen Einfluss auf die Gesamtwerte des PIPP. Bei der subjektiven Einschätzung der Schmerzen mittels NRS schätzen die Schüler den Schmerz geringer ein als die erfahrenen Pflegekräfte. Diese Ergebnisse sind jedoch nicht signifikant.
Schlussfolgerung Die Anwendung des PIPP durch Schüler ist der Anwendung durch erfahrene Pflegekräfte ebenbürtig. Auch die Berufserfahrung mit Neugeborenen in den beiden Gruppen hat scheinbar keinen Einfluss. Beide Gruppen zeigen eine mäßige Streuung der Gesamtwerte (z. B. Video 1: 10,5 [9–12] vs. 10 [6,3–11]).
Trunk Muscle Activity in One- and Two-Armed American Kettlebell Swing in Resistance-Trained Men
Authors: Andersen Vidar , Fimland Marius , Saeterbakken Atle 
Published: March 2019

AbstractThe aim of the study was to compare the one-armed vs. two-armed American kettlebell swing on trunk muscle activation. Fifteen resistance-trained men performed ten repetitions of both exercises using a 14-kg kettlebell. Surface EMG from the erector spinae, rectus abdominis and external oblique muscles were collected on both sides of the trunk. The erector spinae activation during the one-armed swing was 14–25% higher on the contralateral compared to the ipsilateral side in both exercises (Cohen’s d effect size [ES]=0.41–0.71, p ˂ 0.001–0.034). Further, the contralateral side was 14% more activated during the two-armed swing compared to the ipsilateral side during the one-armed swing (ES=0.43, p=0.009). For the rectus abdominis muscle, the two-armed swing induced higher activation of the rectus abdominis compared to the one-armed swing on both the contralateral (40%, ES=0.48, p=0.040) and ipsilateral side (59%, ES=0.83, p=0.002). There were no differences for the external oblique muscle (p=0.495–0.662). In conclusion, the trunk activation patterns of the two exercises were different, which could be explained by different biomechanics in the two exercises, and could thus have complimentary effects. We recommend that both unilateral and bilateral execution of the American kettlebell swing is included over time.
Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa–Factor VIIIa Interactions
Authors: Xiao Chuang , Zhao Longyan , Gao Na , Wu Mingyi , Zhao Jinhua 
Published: March 2019

AbstractA nonasaccharide (FG9) derived from natural fucosylated glycosaminoglycan (FG) is identified as a selective intrinsic factor Xase complex (FIXa-FVIIIa-Ca2+-phospholipid, FXase) inhibitor that possesses potential inhibition of venous thrombus in rats and shows negligible bleeding risk. The mechanism and molecular target of the nonasaccharide for intrinsic FXase inhibition were systematically investigated and compared with low molecular weight heparin (LMWH). Our results showed that FG9 dose-dependently inhibited FX activation by intrinsic FXase complex in a noncompetitive inhibition pattern, where the apparent affinity for FG9 was approximately 1.8-fold higher than that for LMWH. FG9 displayed no inhibitory effect on the activity of FIXa/phospholipid, and did not affect the decay rate of FVIIIa activity. FG9 reduced the apparent affinity of FIXa for FVIIIa in a dose-dependent manner, and accelerated the decay of intrinsic FXase complex activity. FG9 bound to FIXa with high affinity and the FIXa binding sites of FG9 were overlapped with that of LMWH, and the ability of FG-derived oligosaccharides to bind FIXa required the minimum 9 degrees of polymerization. FG9 derivatives were prepared and their structures were confirmed by one-dimensional/two-dimensional nuclear magnetic resonance. Structure–activity relationship studies showed that carboxy reduction significantly weakened its anti-FXase activity and binding affinity to FIXa, while the effects of carboxyl ethyl esterification and deacetylation were relatively weaker. Overall, our results suggest that the nonasaccharide FG9 strongly inhibits intrinsic FXase complex activity via binding to FIXa and disrupting FIXa–FVIIIa interactions, and the free carboxyl groups of FG9 are required for its potent anti-FXase activity.
Delayed Cord Clamping and Umbilical Cord Milking among Infants in California Neonatal Intensive Care Units
Authors: Tran Chinh L. , Parucha Janella M. , Jegatheesan Priya , Lee Henry C. 
Published: March 2019

Objective To assess the current practice of delayed cord clamping (DCC) and to determine patient and hospital factors that predict DCC.
Study Design The California Perinatal Quality Care Collaborative (CPQCC) collects data on preterm and acutely ill infants. In 2016, 52 CPQCC neonatal intensive care units (NICUs) collected data on DCC. Hospital and patient characteristics were analyzed using multivariable logistic regression.
Results Of 5,332 deliveries, 1,555 (29%) newborns received DCC. Hospital rates ranged from 0 to 74.5% and increased from 21 to 37% throughout 2016. Infants delivered at <32 weeks or with birth weight <1,500 g were more likely to receive DCC (odds ratio: 2.80; 95% confidence interval: 2.33, 3.36). Cesarean delivery was associated with less likelihood of DCC (odds ratio: 0.68; 95% confidence interval: 0.59, 0.79). After risk adjustment, 17 (33%) hospitals had higher than expected DCC rate. Hospitals with less than 50 NICU beds are more likely to practice DCC, whereas Level 3 American Academy of Pediatrics NICUs, nonprofit owned hospitals, and teaching institutions were less likely to practice DCC (p < 0.001).
Conclusion There are opportunities to implement quality improvement activities to increase DCC rates.
Effects of cumulative language exposure on heritage and majority language skills
Authors: Tao Lily , Cai Qing , Gollan Tamar H. 
Published: March 2019

AbstractThis study investigated the effects of the amount of cumulative heritage language (HL) exposure during three time periods, on heritage and majority language performance in young adulthood, among two distinct groups of immigrant populations in the USA. Within each time period, exposure from three different sources were examined, and amount of cumulative exposure was calculated encompassing exposure from preceding periods. Factors that may modulate exposure effects were also assessed. Results showed that greater cumulative HL exposure from people at home during all three time periods significantly predicted HL skills for both language groups. For effects on English skills, only the Spanish group showed any influences of exposure. These effects were modulated by parental English proficiency. Input from other sources had less impact. The present findings support the role of parental input throughout childhood, adolescence, and early adulthood in improving HL skills, with less noticeable consequences for the majority language.
Expression, purification, and in vitro mitochondrial interaction analysis of full-length and truncated human tumor suppresser p53
Authors: Wang Lingyao , Zhao Tong , Wang Song , Jin Jingji , Cai Yong , Wang Fei 
Published: March 2019

ABSTRACT
p53 is a potent tumor suppressor which can prevent the propagation of cells carrying oncogenic lesions via a multitude of pathways. Besides the transactivation of downstream genes encoding proapoptotic proteins, p53 is also able to physically interact with mitochondria and induce apoptosis through a so called transcriptional-independent pathway. In this study, we described a quick method for the expression and purification of soluble recombinant p53 and its different truncations in E. coli. These proteins are able to interact with mitochondria and induce mitochondrial outer membrane permeabilization and associated downstream apoptotic events in a cell-free apoptosis analysis system.
Production of Glucose from Waste Bark Acacia Mangium Using Delifnification and Chemical Hydrolysis Process
Authors: Arita S , Hadiah F , Amalia R , Rosmalisa E , Andalia W 
Published: March 2019

Abstract
The bark of Acacia mangium is lignocellulosic biomass from waste pulp which can be recovered by means of hydrolyse to produce simple sugar called glucose. To produce glucose, there are two stages of the process performed is process using solvent delignification NaOH and KOH. The parameters analyzed were the biomass with a solvent ratio (1:6, 1:8, 1:10, 1:12). The second stage cellulose is then hydrolyzed to see the influence of sulfuric acid concentration of the resulting glucose content (0.1; 0.25; 0.40; 0.55% (v/v)).Lignin removal efficiency using NaOH and KOH solvent that is almost equal to 62.39%. Decrease hemicellulose using KOH solvent (36%) are more efficient than solvent only 29.3% NaOH. Efficiency increased levels of cellulose using NaOH or KOH solvent almost equal approximately 85.5%, but with KOH the lower alkaline properties provide a more stable rise. Solvent delignification process with NaOH provide large enough glucose content at a ratio of 1: 6 and 1: 8 with sulfuric acid concentration in the range of 0.1 to 0.4 and 0.5% v/v. Increased glucose content in the solvent of NaOH at a ratio of 1:6 reached 69.88 ppm for sulfuric acid concentration of 0.55% v/v, whereas the content of glucose degradation products of cellulose with delignification process using KOH solvent is in the range of 3.25 ppm to 77.67 ppm. The highest value is produced by the hydrolysis of cellulose to the sulfuric acid concentration of 0.4% v/v, and the KOH solvent ratio is 1:10. The higher the ratio, the lower the KOH solvent content of glucose produced.
Carbon isotope minima in the South Atlantic during the last deglaciation: evaluating the influence of air-sea gas exchange
Authors: Lund D , Hertzberg J , Lacerra M 
Published: March 2019

Abstract
Carbon isotope minima were a ubiquitous feature in the mid-depth (1.5–2.5 km) Atlantic during Heinrich Stadial 1 (HS1, 14.5–17.5 kyr BP) and the Younger Dryas (YD, 11.6–12.9 kyr BP), with the most likely driver being collapse of the Atlantic Meridional Overturning Circulation (AMOC). Negative carbon isotope anomalies also occurred throughout the surface ocean and atmosphere, but their timing relative to AMOC collapse and the underlying drivers have remained unclear. Here we evaluate the lead-lag relationship between AMOC variability and surface ocean δ
13C signals using high resolution benthic and planktonic stable isotope records from two Brazil Margin cores (located at 1.8 km and 2.1 km water depth). In each case, the decrease in benthic δ
13C during HS1 leads planktonic δ
13C by 800 ± 200 years. Because the records are based on the same samples, the relative timing is constrained by the core stratigraphy. Our results imply that AMOC collapse initiates a chain of events that propagates through the oceanic carbon cycle in less than 1 kyr. Direct comparison of planktonic foraminiferal and atmospheric records implies a portion of the surface ocean δ
13C signal can be explained by temperature-dependent equilibration with a 13C-depleted atmosphere, with the remainder due to biological productivity, input of carbon from the abyss, or reduced air-sea equilibration.
Ocean warming pattern effects on future changes in East Asian atmospheric rivers
Authors: Kamae Youichi , Mei Wei , Xie Shang-Ping 
Published: March 2019

Abstract
Atmospheric rivers (ARs), intense water vapor transports associated with extra-tropical cyclones, frequently bring heavy rainfalls over mid-latitudes. Over East Asia, landfalling ARs result in major socio-economic impacts including widespread floods and landslides; for example, western Japan heavy rainfall in July 2018 killed more than 200 people. Using results of high-resolution atmospheric model ensemble simulations, we examine projected future change in summertime AR frequency over East Asia. Different sea surface temperature (SST) warming patterns derived from six atmosphere–ocean coupled model simulations were assumed to represent uncertainty in future SST projections. The rate of increase in the frequency of landfalling ARs over summertime East Asia is on average 0.9% K–1 and is dependent on SST warming patterns. Stronger warming over the North Indian Ocean and South China Sea or weaker warming over the tropical central Pacific produce more frequent landfalling ARs over East Asia. These patterns are similar to the co-variability of SST, atmospheric circulation, and ARs over the western North Pacific found on the interannual time scale. The results of this study suggest that the natural disaster risk related to landfalling ARs should increase over East Asia under global warming and SSTs over the Indo-Pacific region holds the key for a quantitative projection.
D-optimal design of b-values for precise intra-voxel incoherent motion imaging
Authors: Sansone Mario , Fusco Roberta , Petrillo Antonella 
Published: March 2019

Abstract
The aim of this paper is to optimally design the set of b-values for diffusion weighted MRI with the aim of precise estimation of intra-voxel incoherent motion (IVIM) parameters (f perfusion fraction, D

s
slow diffusion, D

f
fast diffusion) according to the model developed by Le Bihan. Previous studies have addressed the design in a Monte Carlo fashion; however, due to huge computation times, this approach is practical only for a limited number of values of the parameters (local design): however, as the parameters of a specific patient are not known a priori, it would be desirable to optimise b-values over a region of parameters. In order to address this issue, we propose to use a D-optimal design approach. Our study has two key results: first, under fairy general conditions, the optimal design does not depend on perfusion fraction: this allow to perform a search over a 2D parameter space instead of 3D; second, as an exhaustive search over all possible designs would still be time consuming, we proposed an algorithm to find an approximate solution very quickly.
Assessing molecular simulation for the analysis of lipid monolayer reflectometry
Authors: McCluskey A R , Grant J , Smith A J , Rawle J L , Barlow D J , Lawrence M J , Parker S C , Edler K J 
Published: March 2019

Abstract
Using molecular simulation to aid in the analysis of neutron reflectometry measurements is commonplace. However, reflectometry is a tool to probe large-scale structures, and therefore the use of all-atom simulation may be irrelevant. This work presents the first direct comparison between the reflectometry profiles obtained from different all-atom and coarse-grained molecular dynamics simulations. These are compared with a traditional model layer structure analysis method to determine the minimum simulation resolution required to accurately reproduce experimental data. We find that systematic limits reduce the efficacy of the MARTINI potential model, while the Berger united-atom and Slipids all-atom potential models agree similarly well with the experimental data. The model layer structure gives the best agreement, however, the higher resolution simulation-dependent methods produce an agreement that is comparable. Finally, we use the atomistic simulation to advise on possible improvements that may be offered to the model layer structures, creating a more realistic monolayer model. Usage: Electronic Supplementary Information (ESI) including all analysis/plotting scripts and figure files, allowing for a fully reproducible, and automated, analysis workflow for the work presented is available at https://github.com/arm61/sim_vs_trad (DOI: 10.5281/zenodo.3254719) under a CC BY-SA 4.0 license. Reduced experimental datasets are available at DOI: 10.15125/BATH-00586, under a CC-BY 4.0 license.
From Epidemiologic Knowledge to Improved Health: A Vision for Translational Epidemiology
Authors: Windle Michael , Lee Hojoon D , Cherng Sarah T , Lesko Catherine R , Hanrahan Colleen , Jackson John W , McAdams-DeMarco Mara , Ehrhardt Stephan , Baral Stefan D , D’Souza Gypsyamber , Dowdy David W 
Published: March 2019

Abstract
Epidemiology should aim to improve population health; however, no consensus exists regarding the activities and skills that should be prioritized to achieve this goal. We performed a scoping review of articles addressing the translation of epidemiologic knowledge into improved population health outcomes. We identified 5 themes in the translational epidemiology literature: foundations of epidemiologic thinking, evidence-based public health or medicine, epidemiologic education, implementation science, and community-engaged research (including literature on community-based participatory research). We then identified 5 priority areas for advancing translational epidemiology: 1) scientific engagement with public health; 2) public health communication; 3) epidemiologic education; 4) epidemiology and implementation; and 5) community involvement. Using these priority areas as a starting point, we developed a conceptual framework of translational epidemiology that emphasizes interconnectedness and feedback among epidemiology, foundational science, and public health stakeholders. We also identified 2–5 representative principles in each priority area that could serve as the basis for advancing a vision of translational epidemiology. We believe an emphasis on translational epidemiology can help the broader field to increase the efficiency of translating epidemiologic knowledge into improved health outcomes and to achieve its goal of improving population health.
Through the eyes of young EFL learners: learning with student teachers
Authors: Yildirim Rana , Orsdemir Esra 
Published: March 2019

Abstract
The importance of the practicum for pre-service teachers is well documented in the teacher education literature. A considerable amount of research has investigated various dimensions of the student teaching experience, from student teachers’ beliefs and perceptions to the problems and challenges they face within the process. However, one important dimension, namely what pupils in the classroom think about working with student teachers, has not been given much attention. Hence, the purpose of this study was to investigate how young EFL learners construe their learning experience with student teachers. Data were collected from the drawings of 35 primary school EFL pupils, and we conducted follow-up interviews in which volunteering pupils described what they had drawn. The findings revealed not only pupils’ classroom experiences with student teachers but also various aspects of mentoring practices carried out in the schools.