bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and outcome of BCR‐ABL mutated chronic myeloid leukemia patients who failed to tyrosine kinase inhibitors
Authors: Etienne Gabriel , Dulucq Stéphanie , Huguet Françoise , Schmitt Anna , Lascaux Axelle , Hayette Sandrine , Fort Marie‐Pierre , Sujobert Pierre , Bijou Fontanet , Morisset Stéphane , Tavitian Suzanne , Bidet Audrey , Turcq Beatrice , Robbesyn Fanny , Chollet Claudine , Belloc Francis , Durrieu Françoise , Mahon François‐Xavier , Nicolini Franck E. 
Published: July 2019

AbstractPurposeTo assess the incidence of BCR‐ABL kinase domain (KD) mutation detection and its prognostic significance in chronic phase chronic myeloid leukemia (CP‐CML) patients treated with tyrosine kinase inhibitors (TKIs).Patients and MethodsWe analyzed characteristics and outcome of 253 CP‐CML patients who had at least one mutation analysis performed using direct sequencing. Of them, 187 patients were early CP (ECP) and 66 were late CP late chronic phase (LCP) and 88% were treated with Imatinib as first‐line TKI.ResultsOverall, 80 (32%) patients harbored BCR‐ABL KD mutations. A BCR‐ABL KD mutation was identified in 57% of patients, who progressed to accelerated or blastic phases (AP‐BP), and 47%, 29%, 35%, 16% and 26% in patients in CP‐CML at the time of mutation analysis who lost a complete hematologic response, failed to achieve or loss of a prior complete cytogenetic and major molecular response, respectively.Overall survival and cumulative incidence of CML‐related death were significantly correlated with the disease phase whatever the absence or presence of a mutation was and for the latter the mutation subgroup (T315I vs P‐loop vs non‐T315I non‐P‐loop) (P<.001). Considering patients who were in CP at the time of mutation analysis, LCP mutated patients had a significantly worse outcome than ECP‐mutated patients despite a lower incidence of T315I and P‐loop mutations (P<.001). With a median follow‐up from mutation analysis to last follow‐up of 5 years, T315I and P‐loop mutations were not associated with a worse outcome in ECP patients (P = .817).ConclusionOur results suggest that early mutation detection together with accessibility to 2nd and 3rd generation TKIs have reversed the worst outcome associated with BCR‐ABL KD mutations whatever the mutation subgroup in CP‐CML patients.
Characterization of phenolic compound antioxidant activity in oat varieties using UHPLC–online ABTS and LC Q‐TOF
Authors: Rao Shiwangni , Santhakumar Abishek B. , Chinkwo Kenneth A. , Blanchard Christopher L. 
Published: July 2019

AbstractBackground and objectivesPhenolic compounds present in oats provide an opportunity for oats to increase its use in the form of functional food. In this study, eight varieties of Australian‐grown whole‐grain oat were investigated for their phenolic composition and antioxidant potential. Ultra‐high‐performance liquid chromatography–online 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), coupled with liquid chromatography quadrupole time‐of‐flight, was used to identify and quantify individual phenolic compounds and their respective antioxidant activity.FindingsConsiderable variation in phenolic content (19.51 ± 1.20–52.49 ± 1.70 mg 100 g−1 GAE) and antioxidant activity was observed among the oat varieties. Several avenanthramides (AVNs) were detected with AVN A and AVN C being the most abundant. AVN C exhibited the highest antioxidant activity followed by caffeic acid, quercetin‐3,4′‐O‐di‐beta‐glucopyranoside derivative, and 6‐hydroxykaempferol 3,5,7,4′‐tetramethyl ether 6‐rhamnoside. Antioxidant activity in AVNs was observed to be the highest in AVN C followed by AVN B and AVN A.ConclusionsHigh levels of AVN C and the range of phenolic compounds present show promise of Australian‐grown oats as an important source of antioxidant compounds. These antioxidant compounds may contribute to consumers' health benefits.Significance and noveltyThis study contributes to the use of oats as potential functional food by characterizing its individual phenolic compounds and their antioxidant activity.
Astonishing improvement of destructive mandibular osteomyelitis by NSAIDs: A rare lesion site in a patient with SAPHO syndrome
Authors: Tago Masaki , Katsuki Naoko E. , Motomura So , Tokushima Yoshinori , Yamashita Shu‐ichi 
Published: July 2019

AbstractWhen patients develop destructive osteomyelitis, clinicians must always consider the possibility of SAPHO syndrome because even extremely destructive osteomyelitis can be cured by NSAIDs.
Direct Synthesis of Substituted (Z)‐Allylic Sulfones by Palladium‐Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates
Authors: Ke Miaolin , Huang Guanxin , Ding Li , Fang Jingjie , Chen Fen‐er 
Published: July 2019

AbstractA palladium‐catalyzed highly stereoselective sulfonylation of vinylethylene carbonates for the precise synthesis of structurally diverse (Z)‐allylic sulfones was achieved with excellent regioselectivity and stereoselectivity (Z/E ratio, up to 99 : 1). This protocol used inexpensive sodium sulfinates as sulfonyl sources to construct valuable (Z)‐allylic sulfones in good to excellent yields. The controlling experiment suggested that the hydroxyl proton came from the α‐hydrogen of sulfone group through 1, 5‐H shift.
Electronic, Structural and Functional Versatility in Tetrathiafulvalene‐Lanthanide Metal–Organic Frameworks
Authors: Castells‐Gil Javier , Mañas‐Valero Samuel , Vitórica‐Yrezábal Iñigo J. , Ananias Duarte , Rocha João , Santiago Raul , Bromley Stefan T. , Baldoví José J. , Coronado Eugenio , Souto Manuel , Mínguez Espallargas Guillermo 
Published: July 2019

AbstractTetrathiafulvalene‐lanthanide (TTF‐Ln) metal–organic frameworks (MOFs) are an interesting class of multifunctional materials in which porosity can be combined with electronic properties such as electrical conductivity, redox activity, luminescence and magnetism. Herein a new family of isostructural TTF‐Ln MOFs is reported, denoted as MUV‐5(Ln) (Ln=Gd, Tb, Dy, Ho, Er), exhibiting semiconducting properties as a consequence of the short intermolecular S⋅⋅⋅S contacts established along the chain direction between partially oxidised TTF moieties. In addition, this family shows photoluminescence properties and single‐molecule magnetic behaviour, finding near‐infrared (NIR) photoluminescence in the Yb/Er derivative and slow relaxation of the magnetisation in the Dy and Er derivatives. As such properties are dependent on the electronic structure of the lanthanide ion, the immense structural, electronic and functional versatility of this class of materials is emphasised.
Effect of hydrogen addition on formation of hydrogen and carbon from methane decomposition over Ni/Al2O3
Authors: Wang Jiaofei , Jin Lijun , Yu Guangsuo , Hu Haoquan 
Published: July 2019

AbstractThe effects of hydrogen addition on the formation of hydrogen and carbon from methane decomposition over Ni/Al2O3 were studied. The results show that the added hydrogen in methane greatly affects the methane conversion, hydrogen output rate, and the properties of the carbon deposits on the surface of the Ni/Al2O3. The methane conversion and hydrogen output rate are significantly improved by the addition of hydrogen. As the flowrate of hydrogen increases from 0 to 25 mL/min, the initial activity of Ni/Al2O3 decreases sharply, while the stability increases first and then decreases due to the suppression of hydrogen to CH4 decomposition in the thermodynamics equilibrium. When the addition flowrate of the hydrogen is 15 mL/min, that is, 37.5% of the methane flowrate, a much higher methane conversion and the best stability of Ni/Al2O3 are obtained. The addition of a specific amount of hydrogen benefits the methane decomposition; however, the excessive hydrogen will suppress the decomposition. Most of the carbon that deposits on the surface of Ni/Al2O3 is filamentous carbon when hydrogen is added to the methane, however, encapsulated carbon is mainly produced when no hydrogen is added. In addition, the formation of encapsulated carbon, which deactivates the catalyst, is inhibited by the added hydrogen.
A Facile Preparation Strategy for TiO2 Spheres by Direct Hydrolysis
Authors: Xin Wuhong , Zhao Zengdian , Yang Xianhai , Cheng Yingzhi , Sun Fazhe , Feng Liu 
Published: July 2019

AbstractWe have developed a convenient and environmentally benign method for the fabrication of sub‐micron‐sized TiO2 spheres through direct hydrolysis, with the assistance of hollow detergent bubbles as template. The samples obtained at elevated temperatures are firstly characterized by X‐ray diffraction (XRD) and the corresponding photocatalytic activities are evaluated by measuring the photocatalytic oxidation of methyl orange (MO). The results reveal that relative crystallinity and crystallite size have mutual influence on photocatalytic property. Then scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are carried out to investigate the morphology. It can be concluded that hollow templates transform into solid TiO2 products without auxiliary additives. This strategy is quite promising for the low cost, no waste effluent and high productivity, providing a wide range of applications in photocatalysis, catalysis, solar‐cell, separation, and purification processes.
The Klotho Variant rs36217263 Is Associated With Poor Response to Cardioselective Beta‐Blocker Therapy Among Filipinos
Authors: Sy Rody G. , Nevado Jose B. , Llanes Elmer Jasper B. , Magno Jose Donato A. , Ona Deborah Ignacia D. , Punzalan Felix Eduardo R. , Reganit Paul Ferdinand M. , Santos Lourdes Ella G. , Tiongco Richard Henry P. , Aherrera Jaime Alfonso M. , Abrahan Lauro L. , Agustin Charlene F. , Aman Aimee Yvonne Criselle L. , Bejarin Adrian John P. , Cutiongco – de la Paz Eva Maria C. 
Published: July 2019

A common drug used for hypertension among Filipinos is beta‐blockers. Variable responses to beta‐blockers are observed, and genetic predisposition is suggested. This study investigated the association of genetic variants with poor response to beta‐blockers among Filipinos. A total of 76 Filipino adult hypertensive participants on beta‐blockers were enrolled in an unmatched case‐control study. Genotyping was done using DNA from blood samples. Candidate variants were correlated with clinical data using χ2 and logistic regression analysis. The deletion of at least one copy of allele A of rs36217263 near Klotho showed statistically significant association with poor response to beta‐blockers (dominant; odds ratio (OR) = 3.89; P = 0.017), adjusted for diabetes and dyslipidemia. This association is observed among participants using cardioselective beta‐blockers (crude OR = 5.60; P = 0.008) but not carvedilol (crude OR = 2.56; P = 0.67). The genetic variant rs36217263 is associated with poor response to cardioselective beta‐blockers, which may become a potential marker to aid in the management of hypertension.
C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes
Authors: Wang Ningjian , Wang Yuying , Zhang Wen , Chen Yi , Chen Xiaoman , Wang Chiyu , Li Qing , Chen Chi , Jiang Boren , Lu Yingli 
Published: July 2019

AbstractBackgroundA higher prevalence of nonalcoholic steatohepatitis (NASH) and advanced stages of fibrosis was observed in type 2 diabetes. We aim to investigate whether C‐peptide is associated with nonalcoholic fatty liver disease (NAFLD) progression in type 2 diabetic adults.MethodsA total of 4937 diabetic participants were enrolled from China in 2018. Liver steatosis was detected by ultrasound. Subjects with NAFLD were categorized into simple NAFLD and probable NASH by the concurrent presence of metabolic syndrome. NAFLD fibrosis score was used to identify patients with probable advanced fibrosis.ResultsIndividuals with a longer history of type 2 diabetes had a lower C‐peptide level and a lower prevalence of probable NASH but a higher prevalence of advanced fibrosis. C‐peptide was positively associated with simple NAFLD and probable NASH, with odds ratios (ORs) of 4.55 [95% confidence interval (CI) 3.16, 6.55] and 5.28 (95% CI 3.94, 7.09), respectively, comparing quartile 4 with quartile 1 (both p for trend <0.001). However, C‐peptide quartiles were negatively associated with the probable presence of advanced fibrosis (Q4 vs. Q1, OR 0.59, 95% CI 0.36, 0.97, p for trend <0.05). A 1‐SD increment of ln(C‐peptide) was also significantly associated with inflammatory and fibrotic progression (OR 1.34, 95% CI 1.27, 1.41; OR 0.88, 95% CI 0.79, 0.98, respectively).ConclusionsSignificant but opposite associations between C‐peptide and inflammatory and fibrotic progression of NAFLD were observed. Understanding islet hormone changes during type 2 diabetes and differentiating the stage of NAFLD may help to personalize treatment strategies for NAFLD patients with type 2 diabetes.
Biophysical potential of crop residues for biochar carbon sequestration, and co‐benefits, in Uganda
Authors: Roobroeck Dries , Hood‐Nowotny Rebecca , Nakubulwa Dianah , Tumuhairwe John‐Baptist , Mwanjalolo Majaliwa Jackson Gilbert , Ndawula Isaac , Vanlauwe Bernard 
Published: July 2019

AbstractIncreasing organic matter/carbon contents of soils is one option proposed to offset climate change inducing greenhouse gas (GHG) emissions, under the auspices of the UNFCC Paris Agreement. One of the complementary practices to sequester carbon in soils on decadal time scales is amending it with biochar, a carbon rich byproduct of biomass gasification. In sub‐Saharan Africa (SSA), there is a widespread and close interplay of agrarian‐based economies and the use of biomass for fuel, which makes the co‐benefits of biochar production for agriculture and energy supply explicitly different from the rest of the world. To date, the quantities of residues available from staple crops for biochar production, and their potential for carbon sequestration in farming systems of SSA have not been comprehensively investigated. We assessed the productivity and usage of biomass waste from maize, sorghum, rice, millet, and groundnut crops; specifically quantifying straw, shanks, chaff, and shells, based on measurements from multiple farmer fields and household surveys in eastern Uganda. Moreover, allometric models were tested, using grain productivity, plant height, and density as predictors. These models enable rapid and low‐cost assessment of the potential availability of feedstocks at various spatial scales: individual cropland, farm enterprise, region, and country. Ultimately, we modeled the carbon balance in soils of major cropping systems when amended with biochar from biomass residues, and up‐scaled this for basic scenario analysis. This interdisciplinary approach showcases that there is significant biophysical potential for soil carbon sequestration in farming systems of Uganda through amendment of biochar derived from unused residues of cereals and legume crops. Furthermore, information about these biomass waste flows is used for estimating the rates of biochar input that could be made to farmlands, as well as the amounts of energy that could be produced with gasifier appliances.
The Female Athlete Body project study: 18‐month outcomes in eating disorder symptoms and risk factors
Authors: Stewart Tiffany M. , Pollard Tarryn , Hildebrandt Tom , Wesley Nicole Y. , Kilpela Lisa S. , Becker Carolyn B. 
Published: July 2019

AbstractObjectiveTo evaluate the efficacy of the Female Athlete Body project (FAB) in reducing eating disorder (ED) symptoms and risk factors.MethodThis study was a community participatory three‐site, two‐arm, cluster randomized controlled trial (RCT). Female collegiate athletes (N = 481) were randomly assigned by team to the FAB intervention, a behavioral ED risk factor reduction program, or a waitlist control condition. Primary analyses examined 18‐month effects for ED pathology. Secondary analyses examined risk factors and correlates (e.g., thin‐ideal internalization, negative mood, Female Athlete Triad knowledge, and body mass index [BMI]).ResultsLinear mixed effects models with team as a cluster level variable and study condition as a between‐subjects variable revealed significantly reduced dietary restraint in FAB teams relative to control teams. FAB teams also reported significantly fewer objective and subjective binge episodes than control teams. Finally, FAB teams showed significantly lower thin‐ideal internalization and increased BMI at 18‐months. No other significant differences were found.DiscussionThis RCT examined the effects of a short intervention on ED pathology and risk factors in female collegiate athletes through 18‐month follow‐up. This trial is one of only three trials with female athletes that have shown long‐term reductions in any ED symptoms or produced positive effects on ED risk factors. The present study is the first to find such effects with athletes using a brief (i.e., 4 hr) intervention at 18‐month follow‐up. Although small effects were found, the current trial provides valuable lessons about future design and implementation of similar trials with athletes.Trial RegistrationClinical trials NCT01735994.
Acoustic accelerometry reveals diel activity patterns in premigratory Port Jackson sharks
Authors: Kadar Julianna , Ladds Monique , Mourier Johann , Day Joanna , Brown Culum 
Published: July 2019

AbstractDistinguishing the factors that influence activity within a species advances understanding of their behavior and ecology. Continuous observation in the marine environment is not feasible but biotelemetry devices provide an opportunity for detailed analysis of movements and activity patterns. This study investigated the detail that calibration of accelerometers measuring root mean square (RMS) acceleration with video footage can add to understanding the activity patterns of male and female Port Jackson sharks (Heterodontus portusjacksoni) in a captive environment. Linear regression was used to relate RMS acceleration output to time‐matched behavior captured on video to quantify diel activity patterns. To validate captive data, diel patterns from captive sharks were compared with diel movement data from free‐ranging sharks using passive acoustic tracking. The RMS acceleration data showed captive sharks exhibited nocturnal diel patterns peaking during the late evening before midnight and decreasing before sunrise. Correlation analysis revealed that captive animals displayed similar activity patterns to free‐ranging sharks. The timing of wild shark departures for migration in the late breeding season corresponded with elevated diel activity at night within the captive individuals, suggesting a form of migratory restlessness in captivity. By directly relating RMS acceleration output to activity level, we show that sex, time of day, and sex‐specific seasonal behavior all influenced activity levels. This study contributes to a growing body of evidence that RMS acceleration data are a promising method to determine activity patterns of cryptic marine animals and can provide more detailed information when validated in captivity.
Maternal genomic variability of the wild boar (Sus scrofa) reveals the uniqueness of East‐Caucasian and Central Italian populations
Authors: Khederzadeh Saber , Kusza Szilvia , Huang Cui‐Ping , Markov Nickolay , Scandura Massimo , Babaev Elmar , Šprem Nikica , Seryodkin Ivan V. , Paule Ladislav , Esmailizadeh Ali , Xie Hai‐Bing , Zhang Ya‐Ping 
Published: July 2019

AbstractThe phylogeography of the European wild boar was mainly determined by postglacial recolonization patterns from Mediterranean refugia after the last ice age. Here we present the first analysis of SNP polymorphism within the complete mtDNA genome of West Russian (n = 8), European (n = 64), and North African (n = 5) wild boar. Our analyses provided evidence of unique lineages in the East‐Caucasian (Dagestan) region and in Central Italy. A phylogenetic analysis revealed that these lineages are basal to the other European mtDNA sequences. We also show close connection between the Western Siberian and Eastern European populations. Also, the North African samples were clustered with the Iberian population. Phylogenetic trees and migration modeling revealed a high proximity of Dagestan sequences to those of Central Italy and suggested possible gene flow between Western Asia and Southern Europe which was not directly related to Northern and Central European lineages. Our results support the presence of old maternal lineages in two Southern glacial refugia (i.e., Caucasus and the Italian peninsula), as a legacy of an ancient wave of colonization of Southern Europe from an Eastern origin.
Seedling recruitment correlates with seed input across seed sizes: implications for coexistence
Authors: Maron John L. , Hajek Karyn L. , Hahn Philip G. , Pearson Dean E. 
Published: July 2019

AbstractUnderstanding controls on recruitment is critical to predicting community assembly, diversity, and coexistence. Theory posits that at mean fecundity, recruitment of highly fecund small‐seeded plants should be primarily microsite limited, which is indicated by a saturating recruitment function. In contrast, species that produce fewer large seeds are more likely to be seed‐limited, which is characterized by a linear recruitment function. If these patterns hold in nature, seed predation that disproportionately affects larger‐seeded species can limit their establishment. We tested these predictions by comparing recruitment functions among 16 co‐occurring perennial forb species that vary by over two orders of magnitude in seed size. We also assessed how postdispersal seed predation by mice influenced recruitment. We added seeds at densities from zero to three times natural fecundity of each species to undisturbed plots and examined spatial variation in recruitment by conducting experiments across 10 grassland sites that varied in productivity and resource availability. Consistent across two replicated years, most species had linear recruitment functions across the range of added seed densities, indicative of seed‐limited recruitment. Depending on year, the recruitment functions of only 19–37% of target species saturated near their average fecundity, and this was not associated with seed size. Recruitment was strongly inhibited by rodent seed predation for large‐seeded species but not for smaller‐seeded species. Proportional recruitment was more sensitive to spatial variation in recruitment conditions across sites for some small‐seeded species than for large‐seeded species. These results contradict the common belief that highly fecund small‐seeded species suffer from microsite‐limited recruitment. Rather, they imply that, at least episodically, recruitment can be strongly correlated to plant fecundity. However, proportional recruitment of small‐seeded species was inhibited at productive sites to a greater extent than large‐seeded species. Results also show that in a system where the dominant granivore prefers larger seeds, low‐fecundity large‐seeded species can suffer from even greater seed‐limited recruitment than would occur in the absence of predators.