bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Making of Science Smart i-THINK: Science Expert Teachers’ Evaluation
Authors: Azid Nurulwahida , Shaik-Abdullah Sarimah , Hashim Mohamed Zuhailah 
Published: July 2018

Science Smart i-Think is an interactive pedagogical tool that was created to facilitate the learning of science among 30 year five rural primary pupils, specifically on the topic Earth, Moon and Sun. The application was intended to enhance higher order thinking skills (HOTS) based on ADDIE model, advanced organizer and mastery learning. It incorporates the following eight thinking maps: circle map, bubble map, double bubble map, tree map, brace map, flow map, multi-flow map and bridge map. Reviewers provided favourable responses on various features in the application (e.g. animation, user-friendliness) that make learning interesting and effective.
Efficiently Verifiable Computations on User Data for Behavior Analysis with Privacy Preservation
Authors: Pooja R. Kotwal Miss. , Mangesh M. Ghonge Prof. , Amol D. Potgantwar Dr 
Published: July 2018

Along with development of internet and web, online social network are becoming important information propagation platform with hundreds of million users worldwide. Online social network attract thousands of million users to use it every day for different purpose. So that tons of user behavior data is generated on internet. Developing endeavors have been committed to mining the inexhaustible behavior data to extract significant information for research purposes to inquire about that, or analyst to develop better ecommerce strategies for business purpose. However the concern arises with this data is security, which is going to be presented to third parties. The most recent decade has seen an assortment of look into works endeavoring to perform information conglomeration in a privacy protecting manner. Most by far of existing techniques give protection to users information yet at the cost of very limited data aggregation operations like calculating sum and mean of particular query, which barely fulfill the requirement of behavior analysis. So that, proposed system mainly focuses on privacy preservation and behavior analysis of online user data. In this paper we use general accumulation and specific collection for behavior analysis. Using cryptographic algorithm we prevent privacy disclosure from both third party data aggregator and analyst. We have executed our technique and assessed its execution utilizing a relational dataset. The results of the experiment shows that this research scheme handle both overall queries and various selective aggregate queries with acceptable computation, privacy, and overheads of the communication effectively.
Use of pedestrian simulation technologies in urban planning and architectural design process <p>Şehir planlama ve mimari tasarım sürecinde yaya simülasyonu teknolojilerinin kullanımı
Authors: Kırlangıçoğlu Cem , Döker Mehmet Fatih 
Published: July 2018

Urban planners and architects have used different design criteria by following project processes different from each other through the ages. The common point of all these projects has been functionality which is one of the most important criteria for human based design. Aesthetics, beauty and similar terms may be arguable but a non-functional spatial design must not be accepted. All spaces, cities, squares, parks, roads and buildings are designed for people. If these urban structures are not suitable for them, people will have serious problems in terms of general circulation. Therefore, ergonomics and functionality terms must be the basic design criteria of all human based urban planning and architectural design processes. How may it be possible to understand an urban design project or a building is functional before constructing it? The aim of this article is to explain the benefits of pedestrian simulation technologies through the design processes in both theoretical and practical frameworks on a case study area which is an underground metro station. A capacity analysis and circulation assessment has been carried out on the metro station by using Massmotion pedestrian simulation software. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetGeçmişten günümüze şehir planlama ve mimarlık alanında gerçekleştirilen çalışmalarda çeşitli tasarım kriterleri kullanılmış, birbirinden farklı planlama süreçleri izlenmiştir. İnsanların kullanımına yönelik gerçekleştirilen hemen hemen tüm çalışmaların en önemli ortak noktası ise ‘kullanışlılık’ olmuştur. Estetik, güzellik ve benzeri göreceli kavramlar tartışılabilir olmakla birlikte, insanların kullanımı için tasarlanan bir yapının fonksiyonel olmaması inşa sonrasında ciddi bir sorun teşkil edecektir. Planlanan kentler, meydanlar, yollar, yapılar kullanışlı olmadığı takdirde kullanıcılar sirkülasyon anlamında sıkıntılar yaşayacaklardır. Bu nedenle gerçekleştirilen tüm şehir planlama ve mimarlık çalışmalarında hem ergonomi hem de kullanışlılık konusuna çok dikkat edilmesi gerekmektedir. Peki, kentsel tasarımı yapılan bir proje alanının ya da mimarlar tarafından tasarlanan bir yapının fonksiyonel olup olmadığı daha inşa edilmeden nasıl anlaşılabilir? Bu çalışmanın amacı, son yıllarda gelişen yaya simülasyonu teknolojilerinin mimarlık ve planlama alanındaki projelerin tasarım değerlendirme süreçlerinde kullanımının yararlarını hem teorik açıdan ortaya koymak hem de gerçekleştirilen örnek bir uygulama üzerinde göstermektir. Çalışma kapsamında bir metro istasyonuna ilişkin mimari çizimler üzerinden kapasite analizi gerçekleştirilmiş, sirkülasyon açısından değerlendirme yapılmıştır. Yaya simülasyonu kapsamında gerekli analizlerin gerçekleştirilmesi amacıyla Massmotion yazılımı kullanılmıştır.
Usefulness of maternal fetal red blood cell count in rhesus-positive pregnant women
Authors: Lebrun Benjamin , Jacquemyn Yves 
Published: July 2018

Abstract

Background
Fetal red blood cells (FRBC) in maternal blood are counted in rhesus-negative women to determine the amount of anti-D immunoglobulin to be administered in the case of a rhesus-positive fetus. In rhesus-positive pregnant women this is done in not always very well-defined indications including trauma, miscarriage, fetal death and diminished fetal movements. The aim of this study is to determine if the detection of FRBC is useful in rhesus-positive pregnant woman. This was done by assessing maternal and fetal characteristics that are more likely to give a positive test.

Materials and methods
This was a retrospective cohort study.

Results
A total of 169 FRBC tests were performed in 161 rhesus-positive pregnant women. FRBC were found in 45 (26.6%) of the women. Three patients experienced a miscarriage although their FRBC tests were negative (p = 0.295). Of the seven patients who experienced unexpected stillbirths, three tested positive. The deaths were not less likely to occur if the results had been negative (p = 0.631). There was a statistically significant difference between the different types of trauma indications (p = 0.025): the test was more likely positive if there had been a fall on the ground or staircase or blunt trauma (p = 0.041, 0.026 and 0.018, respectively). FRBC were not more frequently present in the absence of fetal movements (n = 16, p = 0.693).

Conclusion
FRBC in maternal blood were more likely positive in the case of a fall on the ground, or from a staircase. However, a positive test does not necessarily imply fetal pathology and, therefore, does not contribute to clinical management.
Comprehension of conversational implicatures in L2 English
Authors: Köylü Yılmaz 
Published: July 2018

Abstract
This study investigated the development of the ability to interpret conversational implicatures in English as an L2. The study followed a cross-sectional design and used a methodologically innovative audio-visual interpretation task with an oral production component. By orally reporting their interpretations, participants demonstrated comprehension of conversational implicatures viewed in a video, rather than employing a predetermined response approach used in earlier studies, which neither explore nor reveal how L2 learners understand implicatures. Fifty participants, forty-five learners at three proficiency levels and five native speakers of English, took part in the study. The results indicated that the comprehension of conversational implicatures showed a significant improvement as L2 proficiency increased. Learner responses were additionally coded based on stages of implicature calculation, which demonstrated that not only learners’ correct interpretations but also their incorrect responses provide insights into their interlanguage development. Such a finding further illustrates the superiority of a free response approach over a predetermined one since the former approach can better shed light on L2 learners’ true pragmatic competence in conversational implicatures.
Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer’s Disease
Authors: Chen Lingxuan , Saito Takashi , Saido Takaomi C. , Mody Istvan 
Published: July 2018

AbstractAlzheimer’s disease (AD) is a neurodegenerative disorder that has become a compelling global public health concern. Besides pathological hallmarks such as extracellular amyloid plaques, intracellular neurofibrillary tangles (NFTs), and loss of neurons and synapses, clinical reports have shown that epileptiform activity, even seizures, can occur early in the disease. Aberrant synaptic and network activities as well as epileptiform discharges have also been observed in various mouse models of AD. The newAppNL-Fmouse model is generated by a gene knock-in approach and there are limited studies on basic synaptic properties inAppNL-Fmice. Therefore, we applied quantitative methods to analyze spontaneous excitatory and inhibitory synaptic events in parietal cortex layer 2/3 pyramidal cells. First, by an objective amplitude distribution analysis, we found decreased amplitudes of spontaneous IPSCs (sIPSCs) in agedAppNL-Fmice caused by a reduction in the amplitudes of the large sIPSCs with fast rates of rise, consistent with deficits in the function of parvalbumin-expressing interneurons (PV INs). Second, we calculated the burstiness and memory in a series of successive synaptic events. Lastly, by using a novel approach to determine the excitation-to-inhibition (E/I) ratio, we found no changes in theAppNL-Fmice, indicating that homeostatic mechanisms may have maintained the overall balance of excitation and inhibition in spite of a mildly impaired PV IN function.
ApoE Regulates the Development of Adult Newborn Hippocampal Neurons
Authors: Tensaouti Yacine , Stephanz Elizabeth P. , Yu Tzong-Shiue , Kernie Steven G. 
Published: July 2018

AbstractAdult hippocampal neurogenesis occurs throughout life and is believed to participate in cognitive functions such as learning and memory. A number of genes that regulate adult hippocampal neurogenesis have been identified, although most of these have been implicated in progenitor proliferation and survival, but not in the development into fully differentiated neurons. Among these genes, apolipoprotein E (ApoE) is particularly compelling because the human ApoE isoform E4 is a risk factor for the development of Alzheimer’s disease, where hippocampal neurogenesis is reported to be dysfunctional. To investigate the effects of ApoE and its human isoforms on adult hippocampal neurogenesis and neuronal development, retroviruses carrying a GFP-expressing vector were injected into wild-type (WT), ApoE-deficient, and human targeted replacement (ApoE3 and ApoE4) mice to infect progenitors in the dentate gyrus and analyze the morphology of fully developed GFP-expressing neurons. Analysis of these adult-born neurons revealed significant decreases in the complexity of dendritic arborizations and spine density in ApoE-deficient mice compared with WT mice, as well as in ApoE4 mice compared with ApoE3. These findings demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis and give insight into how ApoE may influence hippocampal-related neurological diseases.
Çok Kategorili Madde Tepki Kuramı Modellerinin Karşılaştırılması
Authors: BÜYÜKKIDIK Serap , ATAR Hakan Yavuz 
Published: July 2018

Bu çalışmada Rosenberg Benlik Saygısı ölçeğinin
madde tepki kuramında farklı çok kategorili modellerde model veri uyumu kontrol
edilip, madde parametreleri kestirimleri arasındaki ilişkilerin seçilen modele
göre farklılaşıp- farklılaşmadığı incelenmiştir. Araştırmada 47974 bireyin
verdiği yanıtlar arasından kayıp veriler temizlendikten sonra rastgele seçilen
Amerika Birleşik Devletli 500, 1000 ve 2000 bireyin tek boyutlu dört kategorili
10 maddelik ölçeğe verdiği yanıtlar kullanılmıştır. Genelleştirilmiş Kısmi
Kredi, 1 parametreli lojistik model gibi sınırlandırılmış Genelleştirilmiş
Kısmi Kredi, Kısmi Kredi ve Aşamalı Tepki modeline 500, 1000 ve 2000 kişilik
örneklemlerden elde edilen verilerden elde edilen -2log-olabilirlik, Akaike bilgi ölçütü ve Bayesian bilgi ölçütü model uyum katsayıları incelendiğinde en fazla uyumun her
koşulda aşamalı tepki modeli ile gerçekleştiği bulunmuştur. Her modelden elde edilen madde parametreleri
arasında manidar yüksek bir ilişkinin olduğu tespit edilmiştir. Farklı modellerden elde edilen bulgulara göre
her üç örneklemden en yüksek ayırt ediciliğe sahip olan maddenin 6. madde, en
az ayırt ediciliğe sahip olan maddenin ise 500 kişilik örneklem için 4. madde,
1000 ve 2000 kişilik örneklemler için ise genelde 8. madde olduğu görülmüştür.
Oyun Tabanlı Öğrenme-Öğretme Yaklaşımının Okul Öncesi Öğrencilerinin Öğrenme Tercihlerine Etkisi
Authors: KOÇ AKRAN Sevda , KOCAMAN İnci 
Published: July 2018

Bu araştırmanın temel amacı, oyun tabanlı
öğrenme-öğretme yaklaşımının okul öncesi
öğrencilerinin öğrenme tercihlerine
etkisini belirlemektir. Baskın-daha az baskın karma yöntem desenin
kullanıldığı araştırmada amaçsal örnekleme yöntemlerinden ölçüt örnekleme
yöntemi kullanılmıştır. Araştırmanın çalışma grubuna Koç Akran (2017)
tarafından geliştirilen yarı yapılandırılmış görüşme formu ve gözlem formu
uygulanmıştır. Verilerin analizinde
öğrencilerin öğrenme tercihlerine ilişkin hazırlanan gözlem formunda yer
alan maddelerin normal dağılım gösterip göstermeme durumu için Shapiro-Wilks
değerine bakılmıştır. Normallik testleri doğrultusunda gözlem formundaki
maddelerin normal dağılım göstermediği görülmüştür. Öğrenme tercihleri ile
ilgili hazırlanan gözlem formunda deney ve kontrol grubundaki öğrencilerin
puanlarını karşılaştırmak için Mann Whitney U-Testi, grupların kendi içindeki
ön test - son test puanlarını karşılaştırmak için ise Wilcoxon İşaretli Sıralar
Testi uygulanmıştır. Yarı yapılandırılmış görüşme formundan elde edilen veriler
içinde betimsel ve içerik analizi yöntemi kullanılmıştır. Araştırmada
sonucunda, oyun tabanlı öğrenme-öğretme yaklaşımında yapılan
uygulamalarla öğrenciler oyunu kurallara uyma, süper kahramanlar gibi gücünü
belli etme ve farklı nesnelerle tanışma olarak tanımladıkları sonucuna
ulaşılmıştır.
Prognosis of Functional Results of Arising or Immature Cataract Phacoemulsification High Myopia
Authors: Pilyagina A. A. , Fabrikantov O. A. , Shutova S. V. 
Published: July 2018

Actuality. Complicated cataract surgery in high myopia is accompanied by the high risk of intra- and postoperative complications caused by this background disease. The presence of lens opalescence influences the results of many functional diagnostic tests. Diagnostic and prognostic research of the modern methods of investigation such as spectral optical coherence tomography, ultrasound biomicroscopy and B-scanning is urgent in patients with high myopia and cataract. The true prognosis of visual functions in these patients will allow solving the problem of cataract phacoemulsification expediency, decreasing the risks of complications.Purpose. To determine prognostic criteria of complicated cataract phacoemulsification outcome in high myopia.Patients and methods. 62 patients (101 eyes) with arising or immature cataract and high myopia were examined. All patients underwent ultrasound biomicroscopy of retinal periphery, ultrasound B-scanning of vitreous body and spectral optical coherence tomography of macular zone preoperatively, in the first postoperative days, in a month, in 6–8 months. We performed the correlation analysis of the initial morphological parameters and postoperative visual acuity. To solve the problem of the favorable outcome prognostication (achieving a certain level of visual acuity by the definite term after surgery) the method of binary logistic regression was used.Results and conclusion. The performed mathematical analysis showed the correlation between the postoperative visual acuity and the initial morphological parameters in a myopic eye: the value of ocular anterior posterior axis, the height of the posterior vitreous detachment, posterior staphyloma, the retinoschisis length in the superior outer segment, epiretinal membrane height, pigmented epithelium destruction and discharge, increased choroidal reflectivity, subfoveal choroidal thickness. We built the mathematical models that allowed predicting with high accuracy the probability of achieving a certain level of postoperative visual acuity following cataract phacoemulsification in high myopia.
Anatomical and Topographical Relations between the Posterior Lens Capsule and the Intraocular Lens in Pseudoexfoliation Syndrome
Authors: Egorova E. V. 
Published: July 2018

Purpose— to study the relations between the posterior capsule (PC) and intraocular lens (IOL) after cataract surgery in pseudoexfoliation syndrome (PEX).Patients and methods. We examined 46 eyes of 37 patients with PEX who underwent a standard and uncomplicated phacoemulsification. The age of patients was 60–94 years. Postoperative period ranged from 1 day to 10 years. An optical coherence tomography (OCT) (RTVue XR Avanti, “Optovue”) was used to image the IOL-PC space in early and late postoperative period.Results. In the first days full contact PC-IOL was not observed in any case. The maximum of space PC-IOL was noted on the first day postoperatively. Posterior capsule had a wavy or folded profile on the scans. In the next two weeks we observed a decrease of the distances between posterior capsule and IOL. After 1 month we noted the formation of capsular bend around optic edge, the full adhesion of posterior capsule to IOL was not detected. In the late postoperative period the fibroplastic and proliferative capsular changes with secondary discontact PC-IOL was noted. Primary inadhesion of a posterior capsule to IOL was recorded in half of the cases.и. High resolution OCT was suitable for quantitative analysis of IOL-PC space. Involution changes in structures of anterior segment in the eyes with PEX had a role in closure of the IOL-PC space. Complete adhesion of posterior capsule to IOL was not observed in the majority of eyes with PEX.
Comparison of Cornea Endothelial Cells Density the After Aspiration of Dense Cataracts using Two Variants of Phacoemulsification Parameters
Authors: Shukhaev S. V. , Boiko E. V. 
Published: July 2018

Purpose: to compare two types of phacoemulsification parameters (combination ultrasound and torsional US with IP) with estimating the number of postoperative complications caused by intraoperative trauma of corneal endothelial cells.Patients and methods. 72 patients underwent phacoemulsification with IOL implantation. Patients were randomly divided into two groups (main n = 33 and control n = 39). During the aspiration of lens fragments in the main group the combination ultrasound was used, while torsional US with IP was used in the control group. Endothelial cell counting and other examinations were performed 1 day, 1 week and 6 months after the surgery.Results. CDVA in the explored groups 1 week after the surgery was similar: the main group — 0.813 ± 0.228, the control group — 0.765 ± 0.250, There was also no statistically significant difference in the thickness of the cornea between the groups: the main group — 533.48 ± 12.41, the control group — 536.44 ± 10.92. At the same time, a statistically significant difference was found in the density of endothelial cells: the main group: 1871.30 ± 187.41 (after 1 week), 1865 ± 178.9 (after 6 months); control group: 1809.63 ± 225.43 (after 1 week), 1791 ± 230.82 (after 6 months). The percentage of cell loss was, respectively, lower in the main group at all times of observation: 3.90% (after 1 day), 4.54% (after 1 week), 4.9% (after 6 months). In the control group: 7.71% (after 1 day), 9.25% (after 1 week), 10.4% (after 6 months).Conclusions. Data obtained in this study has showed the advantages of combination ultrasound in comparison with torsional US with IP, when performing aspiration of dense lenses. Due to lower consumption of ultrasound energy and higher aspiration rate of the fragments, combination ultrasound can reduce the loss of corneal endothelial cells and decrease the number and severity of postoperative complications associated with it.
Visual Functions in Children in Remote Postoperative Period after Laser Treatment of Threshold Stages of Retinopathy of Prematurity
Authors: Pshenichnov M. V. , Kolenko O. V. , Egorov V. V. , Sorokin E. L. 
Published: July 2018

Purpose.Analysis of visual functions in children in remote postoperative period after laser coagulation (LC) of threshold stages of retinopathy of prematurity (ROP).Patients and methods. In 2017, we selected and investigated 18 children, who previously had an LC of threshold stages of ROP in 2008–2009 in the Khabarovsk branch of the S.N. Fyodorov State Institution Eye Microsurgery Complex (continuous sampling method). There were 5 boys and 13 girls aged from 8 to 9 years at the time of LC. Anterior and posterior eye segments of the eyes (biomicroscopy, ophthalmoscopy), visual acuity, clinical refraction, concomitant pathology were evaluated.Results. We have revealed that regressive ROP after LC is characterized by the presence of serious anatomical and functional changes in the eyes. First, these are refractive disorders, which revealed in 90.5% of cases. Most often revealed: myopic refraction — 61% of all cases, of which more than half (53%) is its high degree; or its combination with compound myopic astigmatism (77% eyes); anisometropia was detected in 39% children. These refractive disorders led to the development of strabismus (61% children) and mixed amblyopia (60%). Despite the combined ophthalmologic pathology, 17% children developed visual functions with achievement of binocular vision, in most children visual functions still continue to develop, although they are not high due to amblyopia. High visual acuity (from 0.8 and above) in both eyes was formed in 22% children; visual acuity in the range of 0.5–0.7 in both eyes was formed in 17% children. Unfortunately, 44.5% children at the time of examination had low visual functions (in the range of 0.05–0.4) in both eyes. Extremely low visual acuity (from 0.01 to 0.04) in both eyes was identified in 11% children; absolute blindness in one of the eyes was in 11% children.Conclusions. LC is reliable way to prevent vision loss from retinal detachment in children with threshold stages of ROP.