bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMP2ART systematic review of education for healthcare professionals implementing supported self-management for asthma
Authors: McCleary Nicola , Andrews Amanda , Buelo Audrey , Captieux Mireille , Morrow Susan , Wiener-Ogilvie Sharon , Fletcher Monica , Steed Liz , Taylor Stephanie J. C. , Pinnock Hilary 
Published: October 2018

AbstractDespite a robust evidence base for its effectiveness, implementation of supported self-management for asthma is suboptimal. Professional education is an implementation strategy with proven effectiveness, though the specific features linked with effectiveness are often unclear. We performed a systematic review of randomised controlled trials and controlled clinical trials (published from 1990 and updated to May 2017 using forward citation searching) to determine the effectiveness of professional education on asthma self-management support and identify features of effective initiatives. Primary outcomes reflected professional behaviour change (provision of asthma action plans) and patient outcomes (asthma control; unscheduled care). Data were coded using the Effective Practice and Organisation of Care Taxonomy, the Theoretical Domains Framework (TDF), and Bloom’s Taxonomy and synthesised narratively. Of 15,637 articles identified, 18 (reporting 15 studies including 21 educational initiatives) met inclusion criteria. Risk of bias was high for five studies, and unclear for 10. Three of 6 initiatives improved action plan provision; 1/2 improved asthma control; and 2/7 reduced unscheduled care. Compared to ineffective initiatives, effective initiatives were more often coded as being guideline-based; involving local opinion leaders; including inter-professional education; and addressing the TDF domains ‘social influences’; ‘environmental context and resources’; ‘behavioural regulation’; ‘beliefs about consequences’; and ‘social/professional role and identity’. Findings should be interpreted cautiously as many strategies were specified infrequently. However, identified features warrant further investigation as part of implementation strategies aiming to improve the provision of supported self-management for asthma.
Tuning quantum channels to maximize polarization entanglement for telecom photon pairs
Authors: Jones Daniel E. , Kirby Brian T. , Brodsky Michael 
Published: October 2018

AbstractQuantum networks entangle remote nodes by distributing quantum states, which inevitably suffer from decoherence while traversing quantum channels. Pertinent decoherence mechanisms govern the reach, quality, and rate of distributed entanglement. Hence recognizing, understanding, and modeling those mechanisms is a crucial step in building quantum networks. Here, we study real-life fiber-optic quantum channels that partially filter individual modes of transmitted polarization-entangled states and are capable of introducing dephasing. First, we theoretically model and experimentally demonstrate the combined effect of two independent and arbitrarily oriented polarization-dependent loss elements experienced by each photon of an entangled photon pair. Then, we showcase the compensation of lost entanglement by properly adjusting the channels’ properties and discuss the resulting tradeoff between the entanglement quality and rate. Our results provide insights into the robustness of fiber-optic quantum channels, thus taking an important step toward the realization of quantum networks.
Establishing grading indices of available soil potassium on paddy soils in Hubei province, China
Authors: Li Xiaokun , Zhang Yangyang , Wang Weini , Khan Muhammad Rizwan , Cong Rihuan , Lu Jianwei 
Published: October 2018

AbstractSoil testing is an important diagnostic tool for assessing crop-available soil potassium (K) and hence making appropriate fertilizer recommendation. This study was aimed at correlating grain yield response data to soil-test K extracted with ammonium acetate (NH4OAc), cold nitric acid (HNO3), sodium tetraphenylboron (NaTPB) and boiling HNO3 solution, based on 54 field trials conducted during 2011 to 2015 across 15 counties in Hubei province, China. The specific objectives were to establish abundance and deficiency indices of available soil-K (ASK) for rice (Oryza sativa L.) and make accurate K fertilizer recommendations. Potassium extracted with NaTPB and boiling HNO3 was 1.47 times and 3.61 times higher respectively than that extracted with cold HNO3, while K extracted with cold HNO3 was 1.32 times higher than that extracted with NH4OAc. There were significant logarithmic relationships between crop response and soil-test K. The R2 values for cold HNO3-K and NaTPB-K methods were much higher than for NH4OAc-K method. In order to calibrate the application, the abundance and deficiency indices of ASK categorized by cold HNO3-K in low, medium, high and very high ranges were <50 mg kg−1, 50 to 100 mg kg−1, 100 to 200 mg kg−1 and >200 mg kg−1 respectively, and that defined by NaTPB-K were <60 mg kg−1, 60 to 150 mg kg−1, 150 to 330 mg kg−1 and >330 mg kg−1, respectively. These values could be used to evaluate soil K supplying capacity and make appropriate K fertilizer recommendations for rice.
Pelvic and hypogastric nerves are injured in a rat prostatectomy model, contributing to development of stress urinary incontinence
Authors: Hehemann Marah , Choe Shawn , Kalmanek Elizabeth , Harrington Daniel , Stupp Samuel I. , McVary Kevin T. , Podlasek Carol A. 
Published: October 2018

AbstractUrinary incontinence affects 40% of elderly men, is common in diabetic patients and in men treated for prostate cancer, with a prevalence of up to 44%. Seventy-two percent of prostatectomy patients develop stress urinary incontinence (SUI) in the first week after surgery and individuals who do not recover within 6 months generally do no regain function without intervention. Incontinence has a profound impact on patient quality of life and a critical unmet need exists to develop novel and less invasive SUI treatments. During prostatectomy, the cavernous nerve (CN), which provides innervation to the penis, undergoes crush, tension, and resection injury, resulting in downstream penile remodeling and erectile dysfunction in up to 85% of patients. There are other nerves that form part of the major pelvic ganglion (MPG), including the hypogastric (HYG, sympathetic) and pelvic (PN, parasympathetic) nerves, which provide innervation to the bladder and urethra. We examine if HYG and PNs are injured during prostatectomy contributing to SUI, and if Sonic hedgehog (SHH) regulatory mechanisms are active in the PN and HYG nerves. CN, PN, HYG and ancillary (ANC) of uninjured, sham and CN crush/MPG tension injured (prostatectomy model) adult Sprague Dawley rats (n = 37) were examined for apoptosis, sonic hedgehog (SHH) pathway, and intrinsic and extrinsic apoptotic mechanisms. Fluorogold tracing from the urethra/bladder was performed. PN and HYG response to SHH protein was examined in organ culture. TUNEL, immunohistochemical analysis for caspase-3 cleaved, -8, -9, SHH, Patched and Smoothened (SHH receptors), and neurite formation, were examined. Florogold positive neurons in the MPG were reduced with CN crush. Apoptosis increased in glial cells of the PN and HYG after CN crush. Caspase 9 was abundant in glial cells (intrinsic), while caspase-8 was not observed. SHH and its receptors were abundant in neurons and glia of the PN and HYG. SHH treatment increased neurite formation. PN and HYG injury occur concomitant with CN injury during prostatectomy, likely contributing to SUI. PN and HYG response to SHH treatment indicates an avenue for intervention to promote regeneration and prevent SUI.
Transposable Element Expression in Acute Myeloid Leukemia Transcriptome and Prognosis
Authors: Colombo Anthony R. , Triche Timothy , Ramsingh Giridharan 
Published: October 2018

AbstractOver half of the human genome is comprised of transposable elements (TE). Despite large-scale studies of the transcriptome in cancer, a comprehensive look at TE expression and its relationship to various mutations or prognosis has not been performed. We characterized the expression of TE in 178 adult acute myeloid leukemia (AML) patients using transcriptome data from The Cancer Genome Atlas. We characterized mutation specific dysregulation of TE expression using a multivariate linear model. We identified distinct patterns of TE expression associated with specific mutations and transcriptional networks. Genes regulating methylation was not associated with significant change in TE expression. Using an unpenalized cox regression analysis we identified a TE expression signature that predicted prognosis in AML. We identified 14 candidate prognostic TE transcripts (TEP) that classified AML as high/low-risk and this was independent of mutation-based and coding-gene expression based risk-stratification. TEP was able to predict prognosis in independent cohorts of 284 pediatric AML patients and 19 relapsed adult AML patients. This first comprehensive study of TE expression in AML demonstrates that TE expression can serve as a biomarker for prognosis in AML, and provides novel insights into the biology of AML. Studies characterizing its role in other cancers are warranted.
Drought-induced susceptibility for Cenangium ferruginosum leads to progression of Cenangium-dieback disease in Pinus koraiensis
Authors: Ryu Minji , Mishra Ratnesh Chandra , Jeon Junhyun , Lee Sun Keun , Bae Hanhong 
Published: October 2018

AbstractRecently, the occurrence of “Cenangium-dieback” has been frequent and devastating. Cenangium-dieback is caused by an endophytic fungus Cenangium ferruginosum in stressed pine trees. Progression of the disease in terms of molecular interaction between host and pathogen is not well studied and there is a need to develop preventive strategies. Thus, we simulated disease conditions and studied the associated transcriptomics, metabolomics, and hormonal changes. Pinus koraiensis seedlings inoculated with C. ferruginosum were analyzed both under drought and well-watered conditions. Transcriptomic analysis suggested decreased expression of defense-related genes in C. ferruginosum-infected seedlings experiencing water-deficit. Further, metabolomic analysis indicated a decrease in the key antimicrobial terpenoids, flavonoids, and phenolic acids. Hormonal analysis revealed a drought-induced accumulation of abscisic acid and a corresponding decline in the defense-associated jasmonic acid levels. Pathogen-associated changes were also studied by treating C. ferruginosum with metabolic extracts from pine seedlings (with and without drought) and polyethylene glycol to simulate the effects of direct drought. From RNA sequencing and metabolomic analysis it was determined that drought did not directly induce pathogenicity of C. ferruginosum. Collectively, we propose that drought weakens pine immunity, which facilitates increased C. ferruginosum growth and results in conversion of the endophyte into the phytopathogen causing dieback.
Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form
Authors: Guidi Benedetta , Planchestainer Matteo , Contente Martina Letizia , Laurenzi Tommaso , Eberini Ivano , Gourlay Louise J. , Romano Diego , Paradisi Francesca , Molinari Francesco 
Published: October 2018

AbstractA new transaminase (VbTA) was identified from the genome of the halotolerant marine bacterium Virgibacillus 21D. Following heterologous expression in Escherichia coli, it was located entirely in the insoluble fraction. After a single mutation, identified via sequence homology analyses, the VbTA T16F mutant was successfully expressed in soluble form and characterised. VbTA T16F showed high stability towards polar organic solvents and salt exposure, accepting mainly hydrophobic aromatic amine and carbonyl substrates. The 2.0 Å resolution crystal structure of VbTA T16F is here reported, and together with computational calculations, revealed that this mutation is crucial for correct dimerisation and thus correct folding, leading to soluble protein expression.
The Arabidopsis-Trichoderma interaction reveals that the fungal growth medium is an important factor in plant growth induction
Authors: González-Pérez Enrique , Ortega-Amaro María Azucena , Salazar-Badillo Fatima Berenice , Bautista Elihú , Douterlungne David , Jiménez-Bremont Juan Francisco 
Published: October 2018

AbstractTrichoderma spp colonizes the plant rhizosphere and provides pathogen resistance, abiotic stress tolerance, and enhance growth and development. We evaluated the Arabidopsis-Trichoderma interaction using a split system in which Trichoderma atroviride and Trichoderma virens were grown on PDA or MS medium. Arabidopsis growth was significantly increased at 3 and 5 days post-inoculation with both Trichoderma species, when the fungal strains were grown on PDA in split interaction. The analysis of DR5:uidA reporter line revealed a greater auxin accumulation in root tips when the fungi were grown on PDA in a split interaction. The root hair-defective phenotype of Arabidopsis rhd6 mutant was reverted with both Trichoderma species, even in split interactions. At 12 °C, Trichoderma species in split interactions were able to mitigate the effects of cold stress on the plant, and also Trichoderma induced the AtERD14 expression, a cold related gene. Volatile organic compounds analysis revealed that Trichoderma strains produce mainly sesquiterpenes, and that the type and abundance of these compounds was dependent on the fungal strain and the culture medium. Our results show that fungal nutrition is an important factor in plant growth in a split interaction.
Classification of marine microdebris: A review and case study on fish from the Great Barrier Reef, Australia
Authors: Kroon Frederieke J. , Motti Cherie E. , Jensen Lene H. , Berry Kathryn L. E. 
Published: October 2018

AbstractMarine debris, and in particular plastic pollution, is ubiquitous throughout global marine environments. Here, we present a classification of marine microdebris (i.e. debris between 0.1 μm and <5 mm) tailored to represent synthetic, semi-synthetic and naturally-derived items. The specific aim of this classification is to introduce a level of consistency in the higher-level characterisation of marine microdebris, thereby improving the overall reporting on marine microdebris contamination. We first conducted an extensive literature review on the accumulation of ingested debris in fish to identify discrepancies in marine microdebris reporting as a basis for the new classification. The review reveals the diverse nature of ingested marine microdebris, including items that are non-plastic but often incorrectly reported on as microplastics. We then applied our classification to a case study on wild-caught juvenile coral trout, Plectropomus spp., from the Great Barrier Reef World Heritage Area, Australia. This first report on accumulation of ingested marine debris in commercial fish on the reef demonstrates a high frequency of occurrence and a prevalence of semi-synthetic and naturally-derived fibres. Based on our findings, we offer recommendations on potential improvements for the classification presented, ultimately contributing to a more realistic assessment of the ecological risks of marine microdebris.
Seismic Detection of a Magma Reservoir beneath Turtle Island of Taiwan by S-Wave Shadows and Reflections
Authors: Lin Cheng-Horng , Lai Ya-Chuan , Shih Min-Hung , Pu Hsin-Chieh , Lee Shiann-Jong 
Published: October 2018

AbstractAlthough surface geology, eruption information and clustering seismicity all suggest Turtle Island (Kueishantao) of northern Taiwan is an active volcano, there was no direct evidence to conclude that magma reservoirs exist beneath it. Even less evidence is available to determine their spatial configuration. If the magma reservoirs are filled by liquids and melt, S-waves are totally reflected and leave behind a shadow, like when passing through the Earth’s outer core. We detect both these S-wave shadows and strong reflections from the surface using earthquakes at different depths and azimuths. These observations identify a km-scale molten-filled volume located beneath Turtle Island. The magmatic nature of the reservoir is supported by the onset of non-double-couple earthquakes with strong CLVD (Compensated Linear Vector Dipole) and ISO (Isotropic) components, which show a tensor crack compatible with some volume changes within the reservoir. Combining these results with two independent 3-D velocity models and aeromagnetic anomalies recorded in Taiwan, a partially-molten ~19% low-velocity volume is estimated in the mid-crust (13–23 km), with spatial uncertainties of ~3 km. The elongated direction approximately follows the strike of the Okinawa trough, indicating that the source of the magma reservoir might be a back-arc opening.
On the detection of carbon fibre storage contamination and its effect on the fibre–matrix interface
Authors: Li Quanxiang , Woodhead Andrea L. , Church Jeffrey S. , Naebe Minoo 
Published: October 2018

AbstractContamination caused by inappropriate carbon fibre (CF) storage may have an impact on their end use in reinforced composite materials. Due to the chemical complexity of CFs it is not easy to detect potential contaminants, especially at the early stage during manufacturing and handling. In this paper, X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared (FTIR) spectroscopy and Surface Energy Analysis (IGC-SEA) were used to assess the surfaces of CFs stored in polyolefin zip-lock bags for possible contamination. Only after over 2 months in-bag storage, was XPS capable of detecting a minor increase in nitrogen on the CF surface while FTIR revealed the presence of fatty acid amides and fatty acids, both associated with the storage media. However neither of these techniques were sensitive enough to show significant evolution of the amount of contamination as a function of storage time. In contrast, IGC-SEA distinguished surface energy differences between CFs before and after storage. These differences were found to change as a function of storage time, which were attributed to increases in contamination amounts. Single fibre fragmentation tests indicated that the surface contamination had potential to disrupt the fibre-matrix interface. These findings provide a new method for assessing the surface contamination of CFs with potential application to other materials.
In Silico Study Reveals How E64 Approaches, Binds to, and Inhibits Falcipain-2 of Plasmodium falciparum that Causes Malaria in Humans
Authors: Salawu Emmanuel Oluwatobi 
Published: October 2018

AbstractPlasmodium falciparum malaria, which degrades haemoglobin through falcipain-2 (FP2), is a serious disease killing 445 thousand people annually. Since the P. falciparum’s survival in humans depends on its ability to degrade human’s haemoglobin, stoppage or hindrance of FP2 has antimalarial effects. Therefore, we studied the atomic details of how E64 approaches, binds to, and inhibits FP2. We found that E64 (1) gradually approaches FP2 by first interacting with FP2’s D170 and Q171 or N81, N77, and K76; (2) binds FP2 tightly (ΔGbinding = −12.2 ± 1.1 kJ/mol); and (3) persistently blocks access to FP2’s catalytic residues regardless of whether or not E64 has already been able to form a covalent bond with FP2’s C42. Furthermore, the results suggest that S41, D234, D170, N38, N173, and L172 (which are located in or near the FP2’s catalytic site’s binding pocket) contribute the most towards the favourable binding of E64 to FP2. Their in silico mutations adversely affect E64-FP2 binding affinity with D234L/A, N173L/A, W43F/A, D234L/A, H174F/A, and N38L/A having the most significant adverse effects on E64-FP2 binding and interactions. The findings presented in this article, which has antimalarial implications, suggest that hydrogen bonding and electrostatic interactions play important roles in E64-FP2 binding, and that a potential FP2-blocking E64-based/E64-like antimalarial drug should be capable of being both hydrogen-bond donor and acceptor, and/or have the ability to favourably interact with polar amino acids (such as S41, S149, N38, N173, N77, Q171) and with charged amino acids (such as D234, D170, H174) of FP2. The abilities to favourably interact with ASN, ASP, and SER appears to be important characteristics that such potential drug should have.
Chelating agent-assisted in situ LDH growth on the surface of magnesium alloy
Authors: Shulha T. N. , Serdechnova M. , Lamaka S. V. , Wieland D. C. F. , Lapko K. N. , Zheludkevich M. L. 
Published: October 2018

AbstractIn situformation of layered double hydroxides (LDH) on metallic surfaces has recently been considered a promising approach for protective conversion surface treatments for Al and Mg alloys. In the case of Mg-based substrates, the formation of LDH on the metal surface is normally performed in autoclave at high temperature (between 130 and 170 °C) and elevated pressure conditions. This hampers the industrial application of MgAl LDH to magnesium substrates. In this paper, the growth of MgAl LDH conversion coating directly on magnesium alloy AZ91 at ambient conditions (25 °C) or elevated temperatures is reported in carbonate free electrolyte for the first time. The direct LDH synthesis on Mg alloys is enabled by the presence of organic chelating agents (NTA and EDTA), which control the amount of free and/or hydroxyl bound Mg2+and Al3+in the solution. The application of the chelating agents help overcoming the typical technological limitations of direct LDH synthesis on Mg alloys. The selection of chelators and the optimization of the LDH treatment process are supported by the analysis of the thermodynamic chemical equilibria.
Controlling Fano resonances in multilayer dielectric gratings towards optical bistable devices
Authors: Hoang Thu Trang , Ngo Quang Minh , Vu Dinh Lam , Nguyen Hieu P. T. 
Published: October 2018

AbstractThe spectral properties of Fano resonance generated in multilayer dielectric gratings (MDGs) are reported and numerically investigated in this paper. We examine the MDG consisting of numerous identically alternative chalcogenide glass (As2S3) and silica (SiO2) multilayers with several grating widths inscribed through the structure, emphasizing quality (Q) and asymmetric (q) factors. Manipulation of Fano lineshape and its linear characteristics can be achieved by tailoring the layers’ amount and grating widths so that the proposed structure can be applicable for several optical applications. Moreover, we demonstrate the switching/bistability behaviors of the MDG at Fano resonance which provide a significant switching intensity reduction compared to the established Lorentzian resonant structures.