bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Echocardiographic Comparison of Sutureless and Conventional Aortic Valve Replacement: a Matched Case-Control Study
Authors: Casha Aaron R , Manché Alexander , Camilleri Liberato , Yamagata Kentaro , Santucci Stephanie , Gauci Marilyn , Galea Joseph 
Published: February 2019

Background Patients at a high operative risk for conventional aortic valve replacement (AVR) may be offered sutureless valve implantation. Sutureless valves resemble conventional valves but incorporate an anchoring mechanism without using annular sutures. Methods Pre-operative and six month post-operative echocardiography data from our first year, single centre experience of sutureless valves was compared to conventional aortic valve replacements in patients matched for operative risk. Left ventricular ejection fraction, mean and peak AV gradients and inter-ventricular septal thickness, effective orifice area (EOA) and indexed effective orifice area (iEOA) were measured. Results The drops in mean and peak pre- to post-operative gradients were greater in the sutureless group, p=0.039 and p=0.001 respectively. Post-operative EOA was 1.69 cm2 and 1.26 cm2 (p=0.001) in the sutureless and conventional groups. Similarly iEOA was 0.93 cm2 and 0.74 cm2 (p=0.001) in the sutureless and conventional groups. There was also a reduction in patient prosthesis mismatch (PPM) in the sutureless group as compared to the conventional group (Chi square test p=0.026). Post-operative inter-ventricular septal thickness was 1.13 cm2 in the sutureless group and 1.35 cm2 in the conventional group (p=0.011). Conclusions Use of sutureless valves with a stent framework resulted in larger EOA and iEOA and a diminution in PPM; and lead to a statistically significant faster regression in inter-ventricular septal thickness that is a measure of left ventricular mass. The rate and extent of regression in left ventricular hypertrophy after AVR is important since it determines long-term survival including mortality, heart failure and decreased admission rates.
La democracia PARTICIPATIVA COMO ELEMENTO DEL MODELO DEMOCRÁTICO DEL SIGLO XXI
Authors: RAMÍREZ NÁRDIZ ALFREDO 
Published: February 2019

La democracia ha evolucionado y cambiado desde su mismo origen siempre hacia formulaciones más inclusivas. Esto es, modelos de democracia que han incluido en el cuerpo electoral a grupos sociales que previamente estaban excluidos, modelos de democracia protectores de nuevos derechos que no existían anteriormente, modelos de democracia que asumían elementos novedosos que en un primer momento no se consideraron propios de la democracia o imprescindibles para su desarrollo. La democracia es movimiento. ¿Puede ser la democracia participativa el elemento que caracterice la modernización de la democracia en las primeras décadas del siglo XXI? En este artículo, a través del análisis del
concepto de democracia participativa, se defiende esta tesis
QUALIDADE INSTITUCIONAL E DESENVOLVIMENTO SOCIOECONÔMICO DOS MUNICÍPIOS DO TERRITÓRIO DO SISAL, BAHIA
Authors: Sá Barreto Ricardo Candéa , Duarte Leonardo Batista , Alves Adrielle Victoria Soares 
Published: February 2019

O presente estudo teve como objetivo averiguar a qualidade institucional e a relação com o desenvolvimento socioeconômico dos municípios do Território do Sisal da Bahia. Para isso, mensurou-se o Índice de Qualidade Institucional Municipal (IQIM) do Ministério do Planejamento do Brasil para o ano 2012. Após, analisou-se a existência da correlação do IQIM com outros índices, como GINI, Desenvolvimento Humano (IDH), Produto Interno Bruto (PIB) e PIB per capita de 2000 e 2012, pelo Coeficiente de Pearson. Os resultados do IQIM apontaram que os municípios do sisal apresentam baixo grau de participação, nível mediano de capacidade financeira e alto nível gerencial e também correlação linear relevante entre IQIM e PIB, ao contrário do GINI. Tais análises inferem uma relação positiva entre qualidade institucional e riqueza, mas não com distribuição de renda.
Dakwah Strategies of Sharia Tourism: The Case of Gili Air, North Lombok
Authors: Zaenuri Lalu Ahmad 
Published: February 2019

For the past few years, Lombok in particular and West Nusa Tenggara in general have not only been known as an island of thousand mosques, but also as a world tourist destination, particularly Shari’a compliance (halal) tourism. With such a new branding, respective stakeholders on the island should therefore make an effort to plan strategies for presenting the concept of halal tourism that serve and benefit both domestic and foreign tourists. Dakwah (Islamic propagation/preaching) can play an important role in strengthening local people’s faith while also balancing between religiosity and tourism. This study looks into how the halal tourism ‘brand’ can be manifested in Gili Air, one of the famous small islands of tourist destination located in the northern part of Lombok. The study reveals that the dakwah strategies for shari’a tourism in Gili Air are carried out through twofold strategies, namely da‘wah bi al-lisān and da‘wah bi al-ḥāl. The first refers to a model where the activities of propagation revolve around preaching of Islamic tenets. The latter emphasizes actualization of Islamic doctrines into daily life.
A Model for Predicting Wine Quality in a Rhône Valley Vineyard
Authors: Abbal Philippe , Sablayrolles Jean‐Marie , Matzner‐Lober Eric , Carbonneau Alain 
Published: February 2019

Core Ideas

This modeling study to evaluate wine quality was based on a highly extensive and unique dataset.
The model was validated with the actual scores attributed by the international press.
This work can serve as a basis for studies in other vineyards.
A model was developed as a tool to evaluate wine quality via submodels that represent soil, plants, meteorology, agronomic variables, various vineyard parameters, grape (Vitis vinifera L.) characteristics, and enological practices. The model is based on a highly extensive and unique dataset collected from a single Rhône Valley vineyard (Domaine de Beaurenard) in southern France and the expertise of its winemaker. This modeling study is a first step toward simulating the quality of a wine on the basis of 88 variables in the vineyard and 56 enological variables. The model was validated by comparing the scores predicted by the model with actual scores given by the international press for 49 modeled wines. At the end of the study, the model was compared against other statistical models. Through this model, winemakers can predict future wine quality early and develop improved business strategies. This modeling study was created for and applied directly to the studied situation (Châteauneuf du Pape, Côtes du Rhône, and Rasteau) and is not directly transferable to other situations. Nonetheless, it can serve as a basis for studies in other vineyards because, with the development of precision farming and the multiplication of sensors in agronomy, most wineries will soon have access to the necessary data to model the quality of their wine.
Sunflower Type Influences Yield Prediction using Active Optical Sensors
Authors: Franzen D.W. , Schultz E.C. , DeSutter T.M. , Sharma L.K. , Ashley R. , Bu H. 
Published: February 2019

Core Ideas

Confection sunflower yield was related to active optical sensor readings.
Oilseed sunflower yield was not related to active optical sensor readings.
Oilseed sunflower yield was related to crop height measurements.
Active‐optical (AO) sensors have been used in several crops as a yield‐prediction tool for N management, but not in sunflower (Helianthus annuus). The need for in‐season N and its rate can be determined through using a yield and AO relationship. By comparing predicted yield from an area of sufficient N to another area of the field, the yield difference multiplied by the N required for the additional yield results in the fertilizer N rate. This study was conducted to determine what parameters, including plant height and plant stand, would be most useful in relating AO sensor readings to sunflower yield. The experiments were conducted in 2015 and 2016 on a total of 20 locations in North Dakota. The experimental design was a split‐plot randomized complete block, with six N rates as the main plot treatments and P rate (four in 2015 and two in 2016) as split plot treatment. Since P had no influence on yield, it was ignored in this study. The AO sensors were the GreenSeeker and Holland Crop Circle. The AO sensors were used when the sunflower was at the V6 and V12 growth stages. Manual height and an acoustic height sensor were used on most sites at the time of AO sensor readings. Sensor readings with and without consideration of crop height were subjected to regression analysis with crop yield. The AO sensor readings were related to confection sunflower yield, but not oilseed sunflower yield. Oilseed sunflower yield was most related to crop height.
Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates
Authors: Harer Sunil , Bhatia Manish , Kawade Vikram 
Published: February 2019

Background:
Dihydrofolate reductase is one of the important enzymes for thymidylate
and purine synthesis in micro-organisms. A large number of drugs have been designed to inhibit
microbial DHFR but over the period of time, some drugs have developed resistance and cross
reactivity towards the enzyme. Over the past few decades, benzimidazoles, triazoles and their derivatives
have been grabbing the attention of the synthetic chemists for their wide gamut of antibacterial
and antifungal activities targeting microbial protein DHFR.

Objective:
Our goal behind present investigation is to explore benzimidazoles class of drugs as microbial
DHFR inhibitors by studying ligand-receptor binding interactions, in vitro enzyme inhibition
assay and confirmation of anti-microbial activity against selected pathogenic microorganisms.

Methods:
A library containing thirty novel 2,6-disubstituted 1H-benzimidazoles was synthesized
by one pot condensation of o-nitro aniline or 2,4-dinitro aniline with series of aldehydes or acetophenones
using Na2S2O4 or SnCl2 respectively and reflux for 5-6hr. Structures of compounds have
been confirmed by spectroscopic methods as 1H and 13C NMR, FT-IR and MS. In vitro DHFR inhibition
study was performed by using Epoch microplate reader and IC50 of the test compounds
was compared with Trimethoprim. In vitro antimicrobial activity was performed against selected
clinical pathogens by agar disk diffusion method and MIC (µg/mL) was reported.

Results:
Moderate to good level of DHFR inhibition was observed with IC50 values in the range of
7-23 µM. Compounds B1, B19, B22, B24 and B30 expressed 1.1 to 1.4 folds more prominent
DHFR inhibitory activity as compared to standard Trimethoprim. Remarkable antimicrobial activity
was exhibited by B1, B19, B22, B24 and B30. Molecular docking study revealed perfect binding
of test ligands with key amino acids of DHFR as Phe31, Ile94, Ile5, Asp27, Gln32 and Phe36.

Conclusion:
Nature of 1H-benzimidazole substituents at position 2 and 6 had influence over magnitude
and type of molecular binding and variation in the biological activity. The present series of
1H-benzimidazoles could be considered promising broad-spectrum antimicrobial candidates that
deserve in future for preclinical antimicrobial evaluation and development of newer antimicrobial
agents targeting microbial DHFR.
Non-compliance to Mass Drug Administration Associated with the Low Perception of the Community Members About their Susceptibility to Lymphatic Filariasis in Ankobra, Ghana
Authors: Dicko Ilo , Coulibaly Yaya Ibrahim , Sangaré Modibo , Sarfo Bismark , Nortey Priscillia Awo 
Published: February 2019

Background:
Lymphatic filariasis (LF) is a parasitic disease that has been targeted for
elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra
community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high
(4.5%). Non-compliance to the MDA has been associated with the persistent LF prevalence in endemic
regions.

Objective:
This study determined the factors associated with the non-compliance to the MDA
among patients living in the Ankobra community, Ghana.

Methods:
A cross-sectional study using a one-stage cluster sampling method was used to collect
data between June and July, 2017 in Ankobra. Questionnaires were used to collect data from
health workers, the MDA drug distributors and study participants in Ankobra. Data analysis was
performed using STATA 14. Logistic regression was used to measure the degree of association
between the dependent (non-compliance) and independent variables. Non-compliance rate was defined
as the percentage of individuals who self-reported that they did not actually swallow the
drugs provided during the MDA.

Results:
The MDA coverage and non-compliance rates were 73.5% (147/200) and 33.33%
(49/147) respectively. The main reason for non-compliance was fear of drug adverse events
(75.51%, 37/49). Thought of “not being susceptible to LF” was significantly associated with the
non-compliance (aOR= 2.83, [CI= 1.15, 6.98]).

Conclusion:
Health education about the susceptibility of residents getting LF disease in endemic
community must be intensified to improve compliance to MDA medication ingestion and thus
meet the Global Elimination of Lymphatic Filariasis by 2020.
Molecular Binding and Simulation Studies of Staphylococcus aureus Superantigens with Flavonoid Compounds
Authors: Mohan Ramadevi , Venugopal Subhashree 
Published: February 2019

Background:
Superantigens of Staphylococcus aureus namely enterotoxin A, exfoliative
toxin A, and Toxic shock syndrome toxin-1 cause detrimental effects on the cells of the
immune system.

Methods:
In this work, the toxins were downloaded from the Protein DataBank database and energies
were minimized using KoBaMIN server. Forty flavonoids compounds were identified by
pubchem compound database through extensive literature study and their 3D structures were obtained
by submitting SMILES to CORINA tool. Based on Lipinski’s rule of five, the molecules
were filtered that resulted in 27 compounds. Molecular docking was performed for identifying the
binding and interaction sites of flavonoids with the toxins using Autodock 4.

Results and Conclusion:
The docked complexes were then subjected to molecular dynamics simulation
using Gromacs. The analysis revealed the stability of the complexes as indicated by three hydrogen
bonds formed during the simulation time period of 20 ns.
Serum Alpha-fetoprotein Levels and Response to Direct Antiviral Therapy in Patients with Chronic Hepatitis C: Real-world Results from 1716 Patients in Egypt
Authors: Badawi Rehab , Alboraie Mohamed , Abd-Elsalam Sherief , Abourahma Mohamed Z. , Ramadan Haidi K. , Ahmed Ossama A. , Fouad Mohamed H.A. , Soliman Shaimaa , Mohareb Dina A. , Haydara Tamer , Alnabawy Sherein M. , El kassas Mohamed 
Published: February 2019

Background &Aims:Direct Antiretroviral Agents (DAAs), sofosbuvir-based therapies, have opened a new era in the treatment of chronic HCV infection. The aim of the study was to investigate the potential use of baseline and in serial serum, AFP levels as a predictor for response to DAAs in patients with Chronic Hepatitis C.Methods:This multicenter observational study was carried out on 1716 chronic hepatitis C virusinfected patients who received direct anti-viral drugs for 12 weeks. The primary end point was sustained virological response at 12 weeks after the end of treatment determined by quantitative PCR for HCV RNA. Serum AFP was quantitatively assessed at baseline then after 12week after stoppage of treatment (SVR12).Results:SVR12 rate was 97.8%. Elevated serum AFP was significantly higher in non -SVR group p value (<0.001). There was a significantly marked decrease in AFP after treatment in comparison to pretreatment values. The multivariate logistic regression analysis on the resulting significant variable from the univariate analysis revealed that only AFP was significantly related to the response to direct antiviral therapy in patients with chronic hepatitis C with p <0.001, OR 1.10 (95% CI 1.07:1.12). Other sociodemographic (e.g. Age, gender, BMI, ..) or laboratory factors (Hb, ANC, WBCs, …) did not show any significant association with the patients’ response to treatment.Conclusion:Serum AFP levels were a predictor for response in patients with chronic HCV with the administration of direct antiviral drugs.
An Analysis of Electrocardiograms for Instantaneous Sleep Potential Determination
Authors: Ogundare Oluwatosin 
Published: February 2019

Background:The use of electrocardiograms to establish a relationship between the electrical activity of the heart and the intricacies of sleep is explored to propose a method to predict the time before sleep onset.Recorded Electrocardiograms (ECG) from the National Sleep Research Resource (NSRR) database are analyzed to extract the frequency domain characteristics and used to develop statistical learning models to predict the time before sleep onset. This is known as Time to Sleep (TTS) and is presented as a measure of wakefulness known as Sleep Potential (SP).Methods:Recorded ECG signals that encapsulate a progression from stage 0 (Awake) to stage 5 are sampled at 125 Hz. The Heart Rate Variability (HRV) information is derived by extracting a sequence of R peaks from the QRS complexes. A Fast Fourier Transform (FFT) of the RR tachogram ensues and features are extracted and used to train the multi-layer neural network.Results:A comparison of the measuredvs.predicted values is presented to evaluate the performance of the Deep Neural Network (DNN) in predicting Sleep Potential (SP) values (time before sleep onset) from different points in the ECG derived power spectrum.Conclusion:The research demonstrates a way to generate information on sleep using ECG data which can be provided in real-time from various ambulatory ECG devices. Sleep Potential (SP) values can be very useful in documenting sleep history for better diagnosis and treatment of sleep disorders. It can also be used in the prevention of sleep-related accidents, especially car wrecks.
Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review
Authors: Abtahi Jahan , Malakuti Iman , Ajan Aida 
Published: February 2019

Introduction:Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. The treatment of the choice is total excision. Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor.Case presentation:We report a case of a 55-year-old woman with a solitary slow-growing mass in the right orbit with the involvement of the rectus inferior muscle, and present a review of the recent literature. The lesion had a diameter of 1 cm and was noticed 2 years before the examination. Excisional biopsy confirmed the diagnosis of GCT. The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings characteristic of GCT, including positive reaction for protein S-100, SOX10, and calcitonin and negative reaction for desmin, myogenin, Smooth Muscle Antigen (SMA), Melan-A, and HMB-45. There were no signs of malignancy in this sample. Disturbance of motility was not noted by the patient after surgery.Conclusion:GCT should be included in the differential diagnosis of intraorbital lesions, particularly those that involve the orbit muscles. A biopsy is recommended before surgical resection, to exclude malignancy and prevent radical resection.
Wikipedia y la educación: Entrevista a Luisina Ferrante de Wikimedia Argentina y Carmen Alcázar de Wikimedia México
Authors: Vadillo Guadalupe 
Published: February 2019

<p>Luisina Ferrante y Carmen Alcázar, representantes de los capítulos mexicano y argentino de Wikimedia Foundation (WMF), comentan en esta entrevista cómo ha evolucionado la edición de artículos de Wikipedia a lo largo de 17 años, la validez de la información que contiene y cómo emplearlos en la educación formal. Destacan usos alternativos a la consulta, como la identificación, por parte de los estudiantes, de huecos de información y el desarrollo de contribuciones a artículos ya publicados.</p><p><span>Para visualizar el video vaya al siguiente enlance: <a href="https://youtu.be/OQj6e7YRWfA">https://youtu.be/OQj6e7YRWfA</a></span></p>
La argumentación de Singer en <i>Liberación animal</i>: concepciones normativas, interés en vivir y agregacionismo
Authors: Horta Oscar 
Published: February 2019

Este artículo examina los presupuestos metodológicos, axiológicos y normativos en los que descansa la que posiblemente sea la obra más conocida de Peter Singer, Liberación animal. Se exploran las tensiones entre la posición normativa, de compromisos mínimos, que se intenta adoptar en esa obra, y las posiciones de Singer acerca del utilitarismo de las preferencias y el argumento de la reemplazabilidad. Se buscará elucidar en particular el modo en el que surgen tales tensiones al abordarse la consideración del agregacionismo y el interés en vivir en relación con el uso de animales no humanos.
Comparison of BALP, CTX-I, and IL-4 levels around miniscrew implants during orthodontic tooth movement between two different amounts of force
Authors: Cesur Mine Gecgelen , Ozturk V. Ozgen , Afacan Beral , Sirin F. Burcu , Alkan Afra , Ozer Torun 
Published: February 2019

ABSTRACT

Objectives:
To evaluate the Interleukin-4 (IL-4), bone-specific alkaline phosphatase (BALP), and C-telopeptide of type I collagen (CTX-I) levels in peri-miniscrew crevicular fluid (PMCF) during orthodontic tooth movement between 75 and 150 g of distalization force.

Materials and Methods:
Thirty miniscrews were placed bilaterally between the maxillary second premolars and first molars. The right and the left maxillary canines were moved distally using either 75 or 150 g of force. PMCF samples were collected before loading (T0); at 2 hours (T1) and 24 hours (T2) later; and on days 7 (T3), 14 (T4), 21 (T5), 30 (T6), and 90 (T7) after force application. Enzyme-linked immunosorbent assay kits were used to determine BALP, CTX-I, and IL-4 levels.

Results:
There was no significant difference between the force groups at all time points with respect to BALP, CTX-I, and IL-4 levels (P &gt; .05). There was no significant difference among time points for the two force groups in terms of BALP and IL-4 levels (P &gt; .05). The CTX-I level at T3 was significantly higher than at T0 for both force groups (P &lt; .05).

Conclusions:
Both 75 g and 150 g of orthodontic force are within optimal force limits, and there is no difference in biochemical markers of bone turnover.
Sivas İli Şartlarında Yatay Toprak Kaynaklı Isı Pompasının Isıtma ve Soğutma İçin Performans Analizi
Authors: KILINÇ Ferhat , BUYRUK Ertan , CANER Mustafa 
Published: February 2019

Bu deneysel çalışmada yatay toprak
kaynaklı ısı pompası iki odadan oluşan toplam 51.3 m3 hacme
uygulanarak, Sivas ili şartlarında ısıtma ve soğutma için performans analizi
araştırılmıştır. Kış ve yaz aylarında gerçekleştirilen ölçümlerde; ısıtma ve
soğutma için sırasıyla tipik bir kış/yaz günü olan 16 Aralık ve 29 Haziran
tarihlerinde elde edilen değerler kullanılmıştır. Bu şekilde toprak kaynaklı ısı
pompası uygulamasının Sivas
iline ait davranış
özelliklerinin belirlenmesi amaçlanmıştır. İç ve dış ortam sıcaklıkları, 4 farklı
derinlikte ölçülmüş toprak sıcaklıkları ve ısı pompası elemanlarının giriş
çıkış sıcaklıkları kayıt altına alınmıştır. Ölçülen veriler sistem ve ısı
pompasına ait performans katsayısı değerlerini hesaplamada kullanılmıştır.
Deneysel veriler kullanılarak ısıtma modunda ortalama performans katsayısı
değerleri ısı pompası ve sistem için sırasıyla 2.10 ve 1.83, soğutma modunda ise ısı pompası için ortalama
4.79 ve sistem için ortalama 3.86 olarak hesaplanmıştır. Ayrıca ısı pompası
için ısıtma güç tüketimi ortalama değeri 2.83 kW, soğutma güç tüketimi ortalama değeri 1.69 kW
olarak elde edilmiştir.