bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features
Authors: Watari Jiro , Mitani Seiichiro , Ito Chiyomi , Tozawa Katsuyuki , Tomita Toshihiko , Oshima Tadayuki , Fukui Hirokazu , Kadowaki Shigenori , Natsume Seiji , Senda Yoshiki , Tajika Masahiro , Hara Kazuo , Yatabe Yasushi , Shimizu Yasuhiro , Muro Kei , Morimoto Takeshi , Hirota Seiichi , Das Kiron M. , Miwa Hiroto 
Published: July 2019

AbstractNon-ampullary duodenal adenocarcinoma (NADC) is extremely rare. Little is known about its clinicopathological and molecular features or its management. Herein we retrospectively analyzed the cases of 32 NADC patients, focusing on microsatellite instability (MSI), genetic mutations, CpG island methylator phenotype (CIMP), and immunostaining including mucin phenotype and PD-L1 expression. The incidence of MSI,KRAS/BRAF/GNASmutations and CIMP was 51.6%, 34.4%/3.1%/6.5% and 28.1%, respectively. PD-L1 expression was seen in 34.4% of patients. No significant associations between clinicopathological features andKRAS/BRAF/GNASgenetic mutations or CIMP were found. Histologically non-well-differentiated-type NADCs and those in the 1st portion of the duodenum were significantly associated with later stages (stages III–IV) (P = 0.006 andP = 0.003, respectively). Gastric-phenotype NADCs were frequently observed in the 1st portion and in late-stage patients; their cancer cells more frequently expressed PD-L1. Histologically, the non-well-differentiated type was an independent predictor of PD-L1 expression in cancer cells (OR 25.05,P = 0.04) and immune cells (OR 44.14,P = 0.02). Only late-stage disease (HR 12.23,P = 0.01) was a prognostic factor for worse overall survival in a Cox proportional hazards regression model. Our observation of high proportions of MSI and PD-L1 expression may prompt the consideration of immune checkpoint inhibitors as a new treatment option for NADCs.
Phase Stability and Compressibility of 3R-MoN2 at High Pressure
Authors: Zhou Xuefeng , Yan Mingqi , Dong Mingdong , Ma Dejiang , Yu Xiaohui , Zhang Jianzhong , Zhao Yusheng , Wang Shanmin 
Published: July 2019

AbstractWe report phase stability and compressibility of rhombohedral 3R-MoN2, a newly discovered layer-structured dinitride, using in-situ synchrotron high-pressure x-ray diffraction measurements. The obtained bulk modulus for 3R-MoN2 is 77 (6) GPa, comparable with that of typical transition-metal disulfides (such as MoS2). The axial compressibility along a axis is more than five times stiffer than that along c axis. Such strong elastic anisotropy is mainly attributed to its layered structure with loosely bonded N-Mo-N sandwich interlayers held by weak Van der Waals force. Upon compression up to ~15 GPa, a new hexagonal phase of 2H-MoN2 occurs, which is irreversible at ambient conditions. The structural transition mechanism between 3R and 2H phases is tentatively proposed to be associated with the rotation and translation of sandwich interlayers, giving rise to different layer stacking sequences in both phases. At high temperature, the decomposition of 3R-MoN2 leads to the formation of hexagonal δ-MoN and the onset degassing temperature increases as the pressure increases. In addition, the low-temperature electrical resistivity measurement indicates that 3R-MoN2 behaves as a semiconductor with an estimated band gap of Eg ≈ 0.5 eV. 3R-MoN2 also shows weak antiferromagnetic properties, which probably originates from the occurrence of magnetic zigzag edges in the structure.
Adaptive wavefront correction structured illumination holographic tomography
Authors: Balasubramani Vinoth , Tu Han-Yen , Lai Xin-Ji , Cheng Chau-Jern 
Published: July 2019

AbstractIn this study, a novel adaptive wavefront correction (AWC) technique is implemented on a compactly developed structured illumination holographic tomography (SI-HT) system. We propose a mechanical movement-free compact scanning architecture for SI-HT systems with AWC, implemented by designing and displaying a series of computer-generated holograms (CGH) composed of blazed grating with phase Fresnel lens on a phase-only spatial light modulator (SLM). In the proposed SI-HT, the aberrations of the optical system are sensed by digital holography and are used to design the CGH-based AWC to compensate the phase aberrations of the tomographic imaging system. The proposed method was validated using a standard Siemens star target, its potential application was demonstrated using a live candida rugosa sample, and its label-free three-dimensional refractive index profile was generated at its subcellular level. The experimental results obtained reveal the ability of the proposed method to enhance the imaging performance in both lateral and axial directions.
Intensive blood pressure control is associated with improved patient and graft survival after renal transplantation
Authors: Pagonas Nikolaos , Bauer Frederic , Seibert Felix S. , Seidel Maximilian , Schenker Peter , Kykalos Stylianos , Dürr Michael , Reinke Petra , Babel Nina , Viebahn Richard , Westhoff Timm H. 
Published: July 2019

AbstractBased on data of the SPRINT trial, American hypertension guidelines recently reduced the blood pressure goal from 140/90 mmHg to 130/80 mmHg for subjects with chronic kidney disease (CKD), whereas European guidelines recommend a systolic blood pressure (SBP) of 130–139 mmHg. The present analysis investigates whether a SBP < 130 mmHg is associated with an additional benefit in renal transplant recipients. We performed a retrospective analysis of 815 renal transplant recipients who were stratified according to mean office SBP values < 130 mmHg, 130–139 mmHg or ≥140 mmHg. Patient and graft survival was defined as composite endpoint, follow-up was limited to 120 months. Mean SBP of the follow-up was significantly associated with the composite endpoint (n = 218) with better survival for a SBP < 130 mmHg and 130–139 mmHg compared to ≥140 mmHg (p < 0.001). The differences in the combined endpoint remained significant in Cox regression analysis adjusted for age, gender and eGFR (p = 0.007, HR = 0.58, 95%CI = 0.41–0.53), but not for graft survival alone. Renal transplant recipients with SBP < 130 mmHg had a lower mortality than those with the conservative blood pressure goal <140 mmHg. These data suggest that the new AHA BP targets are safe for renal transplant recipients and – with all limitations of a retrospective analysis - might even be associated with improved outcome.
PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival
Authors: Batsios Georgios , Viswanath Pavithra , Subramani Elavarasan , Najac Chloe , Gillespie Anne Marie , Santos Romelyn Delos , Molloy Abigail R. , Pieper Russell O. , Ronen Sabrina M. 
Published: July 2019

Abstract70–90% of low-grade gliomas and secondary glioblastomas are characterized by mutations in isocitrate dehydrogenase 1 (IDHmut). IDHmut produces the oncometabolite 2-hydroxyglutarate (2HG), which drives tumorigenesis in these tumors. The phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway represents an attractive therapeutic target for IDHmut gliomas, but noninvasive indicators of drug target modulation are lacking. The goal of this study was therefore to identify magnetic resonance spectroscopy (MRS)-detectable metabolic biomarkers associated with IDHmut glioma response to the dual PI3K/(mTOR) inhibitor XL765. 1H-MRS of two cell lines genetically modified to express IDHmut showed that XL765 induced a significant reduction in several intracellular metabolites including 2HG. Importantly, examination of an orthotopic IDHmut tumor model showed that enhanced animal survival following XL765 treatment was associated with a significant in vivo1H-MRS detectable reduction in 2HG but not with significant inhibition in tumor growth. Further validation is required, but our results indicate that 2HG could serve as a potential noninvasive MRS-detectable metabolic biomarker of IDHmut glioma response to PI3K/mTOR inhibition.
Effects of neuromuscular blockade reversal on bispectral index and frontal electromyogram during steady-state desflurane anesthesia: a randomized trial
Authors: Kim Doyeon , Ahn Jin Hee , Jung Hyunjoo , Choi Ka Young , Jeong Ji Seon 
Published: July 2019

AbstractThe degree of neuromuscular blockade reversal may affect bispectral index (BIS) value. One possible reason is that the reverse of neuromuscular blockade affects electromyographic (EMG) signals of fascial muscle. Another reason is, the afferentation theory, the reverse of neuromuscular blockade relieves block signals generated in muscle stretch receptors from accessing the brain through afferent nerve pathways and induces arousal. Inaccurate BIS value may lead to overdose of drugs or the risk of intraoperative awareness. We compared changes in BIS and EMG values according to neuromuscular blockade reversal agents under steady-state desflurane anesthesia. A total of 65 patients were randomly allocated to receive either neostigmine 0.05 mg/kg, sugammadex 4 mg/kg, or pyridostigmine 0.25 mg/kg for neuromuscular blockade reversal under stable desflurane anesthesia, and 57 patients completed the study. The primary outcome was change in BIS and EMG values before and after administration of neuromuscular blockade reversal agents (between train-of-four [TOF] count 1–2 and TOF ratio 0.9). The change in BIS and EMG values before and after administration of neuromuscular blockade reversal agents were statistically different in each group (BIS: Neostigmine group, P < 0.001; Sugammadex group, P < 0.001; Pyridostigmine group, P = 0.001; EMG: Neostigmine group, P = 0.001; Sugammadex group, P < 0.001; Pyridostigmine group, P = 0.001; respectively). The BIS and EMG values had a positive correlation (P < 0.001). Our results demonstrate that the EMG and BIS values have increased after neuromuscular blockade reversal under desflurane anesthesia regardless of the type of neuromuscular blockade reversal agent. BIS should be applied carefully to measure of depth of anesthesia after neuromuscular blockade reversal.
A model for the aberrant DNA methylomes in aging cells and cancer cells
Authors: Zhang Huiming , Zhang Kang , Zhu Jian-Kang 
Published: July 2019

Abstract
DNA methylation at the fifth position of cytosine is a major epigenetic mark conserved in plants and mammals. Genome-wide DNA methylation patterns are dynamically controlled by integrated activities of establishment, maintenance, and removal. In both plants and mammals, a pattern of global DNA hypomethylation coupled with increased methylation levels at some specific genomic regions arises at specific developmental stages and in certain abnormal cells, such as mammalian aging cells and cancer cells as well as some plant epigenetic mutants. Here we provide an overview of this distinct DNA methylation pattern in mammals and plants, and propose that a methylstat, which is a cis-element responsive to both DNA methylation and active demethylation activities and controlling the transcriptional activity of a key DNA methylation regulator, can help to explain the enigmatic DNA methylation patterns in aging cells and cancer cells.
Thermal history modelling of the L chondrite parent body
Authors: Gail Hans-Peter , Trieloff Mario 
Published: July 2019

Context.The cooling history of individual meteorites can be reconstructed if closure temperatures and closure ages of different radioisotopic chronometers are available for a couple of meteorites. If a close similarity in chemical and isotopic composition suggests a common origin from the same parent body, some basic properties of this body can be derived.Aims.The radius of the L chondrite parent body, its formation time, and its evolution history are determined by fitting theoretical models to empirical data of radioisotopic chronometers for L chondrites.Methods.A simplified evolution model for the L chondrite parent body was constructed considering sintering of the initially porous material, temperature dependent heat conductivity, and an insulating regolith layer. Such models were fitted to thermochronological data of five meteorites for which precise data for the Hf-W and U-Pb-Pb thermochronometers have been published.Results.A set of parameters for the L chondrite parent body is found that yields excellent agreement (within error bounds) between a thermal evolution model and thermochonological data of five examined L chondrites. Empirical cooling rate data also agree with the model results within error bounds such that there is no conflict between cooling rate data and the onion-shell model. Two models are found to be compatible with the presently available empirical data: one model with a radius of 115 km and a formation time of 1.89 Ma after CAI formation, and another model with 160 km radius and formation time of 1.835 Ma. The central temperature of the smaller body remains well below the Ni,Fe-FeS eutectic melting temperature and is consistent with the apparent non-existence of primitive achondrites related to the L chondrites. For the bigger model, incipient melting in the central core region is predicted, which opens the possibility that primitive achondrites related to L chondrites could be found.
Die homöopathische Behandlung des Leiomyoms
Authors: Reschke Nonna 
Published: July 2019

ZusammenfassungIn dieser Arbeit wird der homöopathische Ansatz zur Behandlung des Leiomyoms in einer Gruppe von 133 gebärfähigen Frauen gezeigt. Die Behandlung erfolgte mit homöopathischen Einzelmitteln in mittlerer und hoher Potenz. Wir verwendeten pflanzliche, tierische und mineralische Mittel unter systematischer gynäkologischer und Ultraschallkontrolle. Berufliche Einflüsse und Belastungen im Alter von 45 Jahren beeinflussten die Wirksamkeit der Therapie. In den meisten Fällen waren die Ergebnisse konstant und positiv. Sie beweisen die hohe Wirksamkeit der homöopathischen Behandlung, ihre Toleranz und Sicherheit.
Kurzschluss im Nervensystem: Ausgewählte Umweltfaktoren und Mikronährstoffe bei Multipler Sklerose
Authors: Gröber Uwe 
Published: July 2019

ZusammenfassungAls Ursachen für die chronisch entzündliche Autoimmunerkrankung Multiple Sklerose (MS) werden neben einer genetisch bedingten Prädisposition Infektionen und weitere Faktoren wie Rauchen, Übergewicht, Fehlernährung, Stress und Vitamin-D-Mangel diskutiert. Die Ernährung hat über die Darmmikrobiota direkten Einfluss auf die Gesundheit des ZNS. Es zeichnet sich ab, dass eine Ernährung mit ω-3-Fettsäuren und viel Gemüse, Hülsenfrüchten und Vollkornprodukten durch positive Beeinflussung von Darmflora und Darmbarriere bei MS günstig wirkt. Besondere Bedeutung kommt Mikronährstoffen wie Antioxidanzien, Vitamin B12, Biotin und Vitamin A zu.
Imaging of Abnormal Air in the Abdomen and Pelvis
Authors: Sharma Shobhit , McDougal Jonathan , Pandey Tarun , Jambhekar Kedar , Ram Roopa 
Published: July 2019

AbstractThe presence of abnormal air collection on an imaging study is quite often the reason as well as the solution to a diagnostic dilemma. The purpose of this review article is to develop an understanding of anatomical localization and determine etiology of abnormal air collections in the abdomen and pelvis. Abnormal air collections are commonly encountered on imaging studies on a daily basis, and this article will help familiarize the interpreting radiologist with the pathophysiology of these collections and help solve various diagnostic challenges and avoid potential pitfalls.
Ein neues Kurskonzept für die Manuelle Therapie
Authors: Binder Raymond 
Published: July 2019

ZusammenfassungDer VPT Baden-Württemberg führt eine neue Manuelle Therapie Kursserie durch. Die Basis bildet das bisherige Curriculum. Ergänzt wird es um die aktuellen
wissenschaftlichen Erkenntnisse der Manuellen Therapie, der Schmerzphysiotherapie sowie der Therapie cranio-mandibulärer Dysfunktionen. Der Unterricht in diesem
Curriculum bezieht sich in erster Linie auf die klinischen Muster der Patienten, die Therapeuten in der täglichen Arbeit einer physiotherapeutischen Praxis
begegnen. Einen hohen Stellewert haben die Befunderhebung, das Finden des Therapieziels, die Therapieplanung und die Edukation des Patienten – alles praxisnah
umsetzbar.
The symbolism of the built temple.
Authors: Vidal-Casellas D. 
Published: July 2019

Abstract

This chapter aims to deconstruct religious architecture into fundamental elements, shapes, numbers and basic relations. First, it reflects on the relation between the temple as a built space and the value of the holy. The holy is an absolute element, intangible, but which in some way manifests itself to be perceived by the human being. The chapter then examines the process by which a temple is built, above all focusing on how the choice of location responds to a number of questions that are more symbolic than casuistic. Finally, it examines a number of aspects related to the symbolism of the temple and the meaning or meanings that can be attributed to the different elements and built parts of temples, above all Christian ones, but also relating them to those characteristics shared with other religious traditions.
Bible and religious tourism: some cultural proposals.
Authors: Ferrer J. 
Published: July 2019

Abstract

This chapter intends to contribute ideas for incorporating the Bible into the religious and cultural world of tourism. It proposes a unique dialogue between some aspects of the great narration that the Bible represents and various artefacts of the world's cultural history. The latter are found in museums and libraries everywhere and are proposed here as a theme for culture and tourism precisely because of their value in relation to the reading and interpretation of the Bible.
Transformation of cultural identity, tourism and intercultural dialogue: medieval world heritage sites in Serbia between cultural monuments and shrines.
Authors: Ognjević T. 
Published: July 2019

Abstract

This chapter deals with the challenges of church heritage in Serbia with a special focus on the monastery complexes under UNESCO protection in Studenica, Sopoćani and Stari Ras, and in the light of Orthodox monastic communities' lifestyles and their relationship with tourism. At the same time, based on the Artis Center experience within a cultural and creative tourism project, this chapter seeks to highlight the possible models of interpretation of sacred places through the prism of so-called female history, or personal history of Serbian medieval rulers' wives and daughters, who are generally foreigners, but as well-respected saints of Serbian Orthodox churches, create exceptional potential for intercultural dialogue.
Llull, a traveller in the service of the Faith.
Authors: Ensenyat G. 
Published: July 2019

Abstract

This chapter looks at the travels and pilgrimages of Ramon Llull during the Middle Ages. It is shown that Llull's travels had a specific motivation: to contribute to apologetic action. Within Christendom, the object was to convince the civil and religious powers to support his evangelizing projects. Within Islam, Llull carried out his missionary project through dialogue with the motive of converting Muslims to Christianity.
The diachrony of landscapes: a way of sightseeing.
Authors: Garí B. , Carrillo-Rangel D. 
Published: July 2019

Abstract

This chapter focuses on the 'Spiritual Landscapes' research project in Spain, which studies the spaces of spirituality in the Middle Ages. The public participation activities that form part of the project are outlined. These activities are linked to tourism in general (religious tourism in particular), with the aim of facilitating a dialogue with the general public concerning the past and present that is fruitful in terms of increasing an awareness of heritage and the importance of its preservation.
Future for religious heritage and the benefits of European cooperation.
Authors: Coomans T. , Grootswagers L. 
Published: July 2019

Abstract

In 2011, the non-governmental and non-religious organization Future for Religious Heritage (FRH) was founded with the aim of 'promoting, encouraging and supporting the safeguard, maintenance, valorisation and use of places of worship as well as their content and history'. This chapter defines the issue of religious heritage in Europe, introduces the FRH and the benefits of international cooperation, and touches upon best practices among its members.
Environmental Contact and Self-contact Patterns of Healthcare Workers: Implications for Infection Prevention and Control
Authors: Phan Linh T , Maita Dayana , Mortiz Donna C , Bleasdale Susan C , Jones Rachael M 
Published: July 2019

Abstract

Background
Respiratory viruses on fomites can be transferred to sites susceptible to infection via contact by hands or other fomites.

Methods
Care for hospitalized patients with viral respiratory infections was observed in the patient room for 3-hour periods at an acute care academic medical center for over a 2 year period. One trained observer recorded the healthcare activities performed, contacts with fomites, and self-contacts made by healthcare workers (HCWs), while another observer recorded fomite contacts of patients during the encounter using predefined checklists.

Results
The surface contacted by HCWs during the majority of visits was the patient (90%). Environmental surfaces contacted by HCWs frequently during healthcare activities included the tray table (48%), bed surface (41%), bed rail (41%), computer station (37%), and intravenous pole (32%). HCWs touched their own torso and mask in 32% and 29% of the visits, respectively. HCWs’ self-contacts differed significantly among HCW job roles, with providers and respiratory therapists contacting themselves significantly more times than nurses and nurse technicians (P < .05). When HCWs performed only 1 care activity, there were significant differences in the number of patient contacts and self-contacts that HCWs made during performance of multiple care activities (P < .05).

Conclusions
HCWs regularly contact environmental surfaces, patients, and themselves while providing care to patients with infectious diseases, varying among care activities and HCW job roles. These contacts may facilitate the transmission of infection to HCWs and susceptible patients.
Effect of Glove Decontamination on Bacterial Contamination of Healthcare Personnel Hands
Authors: Kpadeh-Rogers Zegbeh , Robinson Gwen L , Alserehi Haleema , Morgan Daniel J , Harris Anthony D , Herrera Natalia Blanco , Rose Laura J , Noble-Wang Judith , Johnson J Kristie , Leekha Surbhi 
Published: July 2019

Abstract
We examined the effect of glove decontamination prior to removal on bacterial contamination of healthcare personnel hands in a laboratory simulation study. Glove decontamination reduced bacterial contamination of hands following removal. However, hand contamination still occurred with all decontamination methods, reinforcing the need for hand hygiene following glove removal.