bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3
Authors: Lee Jaewon J. , van de Ven Robert A. H. , Zaganjor Elma , Ng Mei Rosa , Barakat Amey , Demmers Joris J. P. G. , Finley Lydia W. S. , Gonzalez Herrera Karina N. , Hung Yin Pun , Harris Isaac S. , Jeong Seung Min , Danuser Gaudenz , McAllister Sandra S. , Haigis Marcia C. 
Published: June 2018

Significance
Metastasis is the most common cause of cancer-related death. The function of reactive oxygen species (ROS) in metastasis is conflicting, and it has been observed to promote or inhibit metastasis. Thus, a more in-depth analysis is needed to assess the impact of ROS on metastasis. In this study, we find that local down-regulation of SIRT3 at the leading edge of migrating cells results in elevated ROS levels and activation of Src/focal adhesion kinase signaling. Further, collective cell migration and metastases formation are inhibited by SIRT3, while patient data sets point to an inverse correlation between SIRT3 and breast cancer metastasis.
Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
Authors: Ding Qiang , Gaska Jenna M. , Douam Florian , Wei Lei , Kim David , Balev Metodi , Heller Brigitte , Ploss Alexander 
Published: June 2018

Significance
To shed light on the host range of Zika virus (ZIKV), we surveyed the virus’ ability to infect cells of evolutionarily diverse species. ZIKV replicates efficiently in human, great ape, Old and New World monkey, but not rodent cells. These observations correlated with ZIKV’s ability to blunt the cGAS/STING signaling pathway in all primate cells tested but not in mice. We demonstrate that an enzyme shared by many flaviviruses (NS2B3) is responsible for functionally inactivating this antiviral defense. Our results highlight the importance of the cGAS/STING pathway in shaping the host range of ZIKV, which in turn may guide the development of murine models with inheritable susceptibility to ZIKV and other flaviviruses.
Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging
Authors: Yan Qiuyan , Lu Yanting , Zhou Lulu , Chen Junling , Xu Haijiao , Cai Mingjun , Shi Yan , Jiang Junguang , Xiong Wenyong , Gao Jing , Wang Hongda 
Published: June 2018

SignificanceMany membrane proteins are functioning in aggregations and associating with microdomains, which range from nanometers to micrometers in size. Therefore, it is indispensable to directly analyze these proteins and microdomains in native cell membranes at a single-molecule level. GLUT1 is a ubiquitously expressed protein, contributing to basal and growth factor-stimulated glucose uptake in many tissues. It is overexpressed in almost all tumors. Herein, by direct stochastic optical reconstruction microscopy, we previously mapped GLUT1 on native cell membranes and highlighted key contributions of the lipid raft, cytoskeleton, and glycosylation to the formation of clusters. Moreover, we elucidated that the clustered distribution of the transporter was associated with its activation, which is crucial to advance our understanding of the transporter’s spatial organization and activation mechanism.
ANXA2 could act as a moderator of EGFR-directed therapy resistance in triple negative breast cancer
Authors: Zhang Yue , Bi Jiajia , Zhu Hongtao , Shi Mei , Zeng Xianlu 
Published: June 2018

ABSTRACT
Triple negative breast cancer (TNBC) patients cannot benefit from EGFR-targeted therapy even though the EGFR is highly expressed, because patients exhibit resistance to these drugs. Unfortunately, the molecular mechanisms remain relatively unknown. ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. In this study, MDA-MB-231 cells and MCF7 cells were used. Our results showed that ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, we demonstrated that phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib. Altogether, our results suggest a new role of ANXA2 in regulating sensitivity of TNBC MDA-MB-231 cells to the EGFR inhibitor gefitinib.
Number concepts: abstract and embodied
Authors: Fischer Martin H. , Shaki Samuel 
Published: June 2018

Numerical knowledge, including number concepts and arithmetic procedures, seems to be a clear-cut case for abstract symbol manipulation. Yet, evidence from perceptual and motor behaviour reveals that natural number knowledge and simple arithmetic also remain closely associated with modal experiences. Following a review of behavioural, animal and neuroscience studies of number processing, we propose a revised understanding of psychological number concepts as grounded in physical constraints, embodied in experience and situated through task-specific intentions. The idea that number concepts occupy a range of positions on the continuum between abstract and modal conceptual knowledge also accounts for systematic heuristics and biases in mental arithmetic, thus inviting psycho-logical approaches to the study of the mathematical mind.This article is part of the theme issue ‘Varieties of abstract concepts: development, use and representation in the brain’.
The case of CAUSE: neurobiological mechanisms for grounding an abstract concept
Authors: Pulvermüller Friedemann 
Published: June 2018

How can we understand causal relationships and how can we understand words such as ‘cause’? Some theorists assume that the underlying abstract concept is given to us, and that perceptual correlation provides the relevant hints towards inferring causation from perceived real-life events. A different approach emphasizes the role of actions and their typical consequences for the emergence of the concept of causation and the application of the related term. A model of causation is proposed that highlights thefamily resemblancebetween causal actions and postulates that symbols are necessary forbinding together the different partially shared semantic features of subsetsof causal actions and their goals. Linguistic symbols are proposed to play a key role in binding the different subsets of semantic features of the abstract concept. The model is spelt out at the neuromechanistic level of distributed cortical circuits and the cognitive functions they carry. The model is discussed in light of behavioural and neuroscience evidence, and questions for future research are highlighted. In sum, taking causation as a concrete example, I argue that abstract concepts and words can be learnt and grounded in real-life interaction, and that the neurobiological mechanisms realizing such abstract semantic grounding are within our grasp.This article is part of the theme issue ‘Varieties of abstract concepts: development, use and representation in the brain'.
Grounding evaluative concepts
Authors: Fingerhut Joerg , Prinz Jesse J. 
Published: June 2018

Evaluative concepts qualify as abstract because they seem to go beyond what is given in experience. This is especially clear in the case of moral concepts. Justice, for example, has no fixed appearance. Less obviously, aesthetic concepts may also qualify as abstract. The very same sensory input can be regarded as beautiful by one person and ugly by another. Artistic success can also transcend sensory accessible features. Here, we focus on moral badness and aesthetic goodness and argue that both can be grounded in emotional responses. Emotions, in turn, are grounded in bodily perceptions, which correspond to action tendencies. When we conceptualize something as good or bad (whether in the moral or aesthetic domain), we experience our bodily responses to that thing. The moral and aesthetic domains are distinguished by the emotions that they involve.
This article is part of the theme issue ‘Varieties of abstract concepts: development, use and representation in the brain’.
Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment
Authors: Li Lingjie , Wang Yong , Torkelson Jessica L. , Shankar Gautam , Pattison Jillian M. , Zhen Hanson H. , Duren Zhana , Fang Fengqin , Melo Sandra P. , Piekos Samantha N. , Li Jiang , Liaw Eric J. , Chen Lang , Li Rui , Wernig Marius , Wong Wing H. , Chang Howard Y. , Oro Anthony E. 
Published: June 2018

SUMMARYTissue development results from lineage-specific transcription factors (TF) programming a dynamic chromatin landscape through progressive cell fate transitions. Here, we interrogate the epigenomic landscape during epidermal differentiation and create an inference network that ranks the coordinate effects of TF-accessible regulatory element-target gene expression triplets on lineage commitment. We discover two critical transition periods: surface ectoderm initiation and keratinocyte maturation, and identify TFAP2C and p63 as lineage initiation and maturation factors, respectively. Surprisingly, we find that TFAP2C, and not p63, is sufficient to initiate surface ectoderm differentiation, with TFAP2C-initiated progenitor cells capable of maturing into functional keratinocytes. Mechanistically, TFAP2C primes the surface ectoderm chromatin landscape and induces p63 expression and binding sites, thus allowing maturation factor p63 to positively auto-regulate its expression and close a subset of the TFAP2C-initiated early program. Our work provides a general framework to infer TF networks controlling chromatin transitions that will facilitate future regenerative medicine advances.
Benchmarking the logistics management implementation using Delphi and fuzzy DEMATEL
Authors: Mangla Sachin Kumar , Luthra Sunil , Jakhar Suresh Kumar , Tyagi Mohit , Narkhede Balkrishna Eknath 
Published: June 2018

Purpose
From last few decades, logistics management (LM) constitutes a global concern among organization’s supply chain (SC) to improve their business effectiveness. The purpose of this paper is to uncover and analyze the critical factors (CFs) related to the implementation of effective LM concept and benchmark the SC performance.

Design/methodology/approach
The most common (16) CFs were identified and selected through literature and use of the Delphi method. Subsequently, the selected most common CFs were analyzed to distinguish their causal relations using the fuzzy Decision Making Trial and Evaluation Laboratory (DEMATEL) technique under unclear surroundings. A case example of Indian Logistics Company is also discussed to reveal the practical applicability of the research.

Findings
Provision of the effective information communication and technological developments in the system and Management dedication, support and involvement CFs are found to have the top most influences in the effective implementation of LM. This paper also groups the CFs into cause and effect relationship which provides valuable insights for analyzing the factors in successful implementation of LM.

Practical implications
This work attempts to understand the different CFs, their relative position and the importance rating in the system, due to which, managers can differentiate the factor which greatly affects the concepts of implementing LM, and thus, improvements can be made accordingly.

Originality/value
First, this work offers 16 CFs to LM implementation from a SC scenario. Second, in the context of contributing to the theory, the combined Delphi and fuzzy DEMATEL-based model is provided that helps in managing the logistic related issues effectively.
Evaluating the key performance indicators for supply chain information system implementation using IPA model
Authors: Ganguly Kunal , Rai Siddharth Shankar 
Published: June 2018

Purpose
To enhance the transparency of the supply chain and ensure proper dissemination of information among the supply chain members in a timely manner, more and more companies are implementing supply chain information system (SCIS). Often the challenge among the organizations is how to go for a proper SCIS implementation and to identify the key performance indicators (KPIs) to evaluate the SCIS. The purpose of this paper is to provide a framework to evaluate the KPIs for SCIS of SCISs implementation from user’s perspectives.

Design/methodology/approach
In this paper, 16 KPIs were identified based on extensive literature survey. A fuzzy analytic hierarchy process (AHP) model is constructed to measure the users’ perceived importance and satisfaction for the KPIs. Subsequently, based on these two measurements, an importance-performance analysis (IPA) model along with a customer satisfaction attitude (SA) index is developed to categorize and prioritize the KPIs. As an empirical study, SCIS users across five industries belonging to different sectors were investigated to validate the model.

Findings
An IPA model along with a customer SA index is developed based on a fuzzy AHP model to evaluate the KPIs and provide the priorities of their improvement. Based on this result, some management implications and suggestions are proposed.

Research limitations/implications
The study was limited to five organizations. More representative samples which can be sector specific can ensure better confirmation of the empirical results.

Originality/value
The KPIs identified in the research indicate the nature and dynamics of a complex SCIS implementation. It can serve as a checklist of areas that require attention when implementing a SCIS. The KPIs are presented through grouping in a systemic way. The development of the SAs in IPA model using fuzzy AHP is a novel approach.
Banking on foreign currency accounts: evidence from Malaysia
Authors: Ong Hway Boon 
Published: June 2018

Purpose
The purpose of this paper is to study how the foreign currency account (FCA) is affected by the domestic fixed deposit (FD) rate, the FCA rate, the expected exchange rate and exchange rate risk.

Design/methodology/approach
This paper analyses the causal relationship between the domestic FD rate, the FCA rate, the expected exchange rate on a set of foreign currency deposits and exchange rate volatility, based on the theory of portfolio choice. Based on the theory, the panel vector autoregressive regression of fully modified ordinary least squares and dynamic ordinary least squares are modelled.

Findings
There is no cointegrating relationship for the three-month FCA deposits, the domestic FD rate, the FCA rate and the expected exchange rate. Only the six-month FCA business deposits are affected by the domestic FD rate, the FCA rate and the expected exchange rate. The FCA depositors are not affected by exchange rate volatility.

Research limitations/implications
This study is conducted based on the FCA rate quoted by the leading commercial banks in Malaysia, Maybank. Thus, the FCA rate is used as a proxy for the FCA rate of commercial banks in Malaysia.

Originality/value
Individual depositors have to save in more than the three-month FCA to realise their expected return. For individuals, the FCA deposit is not an alternative choice to domestic FD. Exporters may use the FCA deposit to finance their foreign purchases to save the cost of foreign exchange conversion but it is still not an appropriate hedging tool against foreign exchange fluctuations as compared to the existing forward foreign exchange facility.
Breach or bridge your career? Understanding the relationship between career plateau and internal employability
Authors: Lin Yi-chun , Chen Angela Shin-yih , Lai Yu-ting 
Published: June 2018

PurposeThe purpose of this paper is to identify the impact of career plateau (hierarchical and job-content plateau) on internal employability, and to investigate psychological contract breach as a moderator on the relationship between career plateau (hierarchical and job-content plateau) and internal employability.Design/methodology/approachData were collected by distributing paper-based questionnaires to 521 workers in private banking sectors in Taiwan. Hierarchical regression analysis was used to examine the results of the relationships.FindingsThe results supported the idea that career plateau (hierarchical and job-content plateaus) could be a significant antecedent of internal employability. Psychological contract breach significantly moderated the negative relationship between career plateau (hierarchical and job-content plateau) and internal employability. Specifically, the negative relationship between career plateau and internal employability will be stronger for employees who perceive a higher level of psychological contract breach.Practical implicationsThese findings can help human resource practitioners gain a better understanding of the value of applicable approaches as an influence on a plateaued employee’s perception of internal employability, and to facilitate a positive employer–employee relationship, which could foster both a successful career for an individual and a prosperous performance for the organization that employs them.Originality/valueCareer plateau have been aroused variety issues in HR practice, but employability and psychological contract breach have barely been discussed with career plateau. This study empirically establishes the correlation between career plateau and internal employability as well as shown that psychological contract breach would decrease the plateaued individual’s willingness to stay in the current organization. Thus, the career plateau may provide organizations with a helpful perspective on one’s career development. Building substantial relationships between employees and employers lead to better human capital for organizations as it deals with rapidly changes in the real world.
Plant demographic and functional responses to management intensification: A long‐term study in a Mediterranean rangeland
Authors: Garnier Eric , Fayolle Adeline , Navas Marie‐Laure , Damgaard Christian , Cruz Pablo , Hubert Daniel , Richarte Jean , Autran Paul , Leurent Corentin , Violle Cyrille 
Published: June 2018

Abstract

Understanding how functional traits, which are key for plant functioning, relate to demographic parameters of populations is central to tackle pending issues in plant ecology such as the forecast of the fate of populations and communities in a changing world, the quantification of community assembly processes or the improvement of species distribution models. We addressed this question in the case of species from a Mediterranean rangeland of southern France.

Changes in species abundance in response to management intensification (fertilization and increased grazing pressure) were followed over a 28‐year period. Probabilities of presence, and elasticities of the changes in the probability of space occupancy to colonization and survival, which are analogues of demographic parameters, were calculated for 53 species from the time series of abundance data using a space occupancy model. Nine quantitative traits pertaining to resource use, plant morphology, regeneration and phenology were measured on these species and related to demographic parameters.

The long‐term dynamics of species in response to management intensification was associated with major changes in functional traits and strategies. Changes in the probability of occurrence—analogous to population growth rate—were correlated with traits describing the fast‐slow continuum of leaf functioning. The elasticity of population growth rate to colonization was significantly related to reproductive plant height and seed mass, and to a lower extent, to leaf carbon isotopic ratio.

Synthesis. The functional response of species to management intensification corresponds to a shift along the second axis of a recently identified global spectrum of plant form and function, which maps, to some extent, onto the fast‐slow continuum of life‐history strategies. By contrast, the elasticity of colonization relates to the global spectrum axis capturing the size of organs. Seed mass contributes to this axis and is assumed to relate to one of the important traits structuring the reproductive strategy axis of life histories as well, namely net reproductive rate. While this mapping between functional and life‐history traits is appealing, further tests in contrasting types of communities are required to assess its degree of generality.
Continental‐scale macrofungal assemblage patterns correlate with climate, soil carbon and nitrogen deposition
Authors: Andrew Carrie , Halvorsen Rune , Heegaard Einar , Kuyper Thomas W. , Heilmann‐Clausen Jacob , Krisai‐Greilhuber Irmgard , Bässler Claus , Egli Simon , Gange Alan C. , Høiland Klaus , Kirk Paul M. , Senn‐Irlet Beatrice , Boddy Lynne , Büntgen Ulf , Kauserud Håvard 
Published: June 2018

AbstractAimMacroecological scales of species compositional trends are well documented for a variety of plant and animal groups, but remain sparse for fungi, despite their ecological importance in carbon and nutrient cycling. It is, thus, essential to understand the composition of fungal assemblages across broad geographical scales and the underlying drivers. Our overall aim was to describe these patterns for fungi across two nutritional modes (saprotrophic and ectomycorrhizal). Furthermore, we aimed to elucidate the temporal component of fruiting patterns and to relate these to soil carbon and nitrogen deposition.LocationCentral and Northern Europe.MethodsA total of 4.9 million fungal fruit body observations throughout Europe, collected between 1970 and 2010, were analysed to determine the two main environmental and geographical gradients structuring fungal assemblages for two main nutritional modes, saprotrophic and ectomycorrhizal fungi.ResultsTwo main gradients explaining the geography of compositional patterns were identified, for each nutritional mode. Mean annual temperature (and related collinear, seasonal measures) correlated most strongly with the first gradient for both nutritional modes. Soil organic carbon was the highest correlate of the second compositional gradient for ectomycorrhizal fungi, suspected as an indicator of vegetation‐ and pH‐related covariates. In contrast, nitrogen deposition constituted a second gradient for saprotrophic fungi, likely a proxy for anthropogenic pollution. Compositional gradients and environmental conditions correlated similarly when the data were divided into two time intervals of 1970–1990 and 1991–2010. Evidence of compositional temporal change was highest with increasing elevation and latitude.Main conclusionsFungal assemblage patterns demonstrate clear biogeographical patterns that relate the nutritional modes to their main environmental correlates of temperature, soil organic carbon and nitrogen deposition. With respect to global change impacts, the highest rates of compositional change by time suggest targeting higher latitudes and elevations for a better understanding of fungal dynamics. We, finally, suggest further examination of the ranges and dispersal abilities of fungi to better assess responses to global change.