bluuebunny/crossref_metadata_2025_split huggingface dataset:
HE4 Levels in Ovarian Cancer-Resistant Menopausal Women
Authors: Irawan Wiwi , Rauf Syahrul , A. Mappaware Nasrudin , T. Chalid St. Maisuri 
Published: August 2019

Abstract

Objective: To analyse the predictive value of HE4 in ovarian cancer patients according to their resistance and menopausal status
Methods: Thirteen premenopausal and twenty-five menopausal ovarian cancer patients were measured for HE4 levels measured using automated chemiluminescent microparticle immunoassay ARCHITECT HE4. Patients categorized into resistant and non-resistant after six cycles of chemotherapy in addition to their clinical symptoms and ultrasound image of cancer.
Results: The mean HE4 levels were higher in the resistant group compared with a non-resistant group (274.97 pmol/l vs 128.83 pmol/l; p=0.015). Five menopausal resistant women with HE4 levels >140 pmol/l compared with two women in the non-resistant group. In the pre-menopause group, eight resistant women with HE level >70 pmol/l whereas four women in the non-resistant group. HE levels in menopausal and premenopausal for both ovarian cancers resistant and non-resistant were not significantly different (p>0.05).
Conclusion: HE4 levels in resistant ovarian cancer patients are higher compared with non-resistant but do not predict ovarian cancer resistance based on patient menopausal status.
Keywords: HE4, ovarian cancer, resistance.

Abstak
Tujuan: Untuk menganalisis nilai prediktif HE4 pada pasien kanker ovarium berdasarkan resistensi dan status menopausenya
Metode: Dilakukan pengukuran kadar HE4 menggunakan metode microparticle immunoassay ARCHITECT HE4 terhadap pasien kanker ovarium terdiri dari 13 perempuan premenopausal dan 25 perempuan menopause. Pasien dikategorikan menjadi resisten dan tidak resisten setelah 6 siklus kemoterapi selain gejala klinis dan gambar USG.
Hasil: Rerata kadar HE4 rata-rata lebih tinggi pada kelompok yang resisten dibandingkan dengan kelompok yang tidak resisten (274,97 pmol/l vs 128,83 pmol/l; p=0,015). Terdapat 5 perempuan menopause yang resisten kanker ovarium dan 2 perempuan dalam kelompok yang tidak resisten dengan kadar HE4 >140 pmol/l. Pada kelompok premenopause, 8 perempuan yang resisten dengan tingkat HE >70 pmol/l sedangkan 4 perempuan dalam kelompok tidak resisten. Kadar HE dalam menopause dan premenopause untuk kedua kanker ovarium resisten dan tidak resisten tidak berbeda secara signifikan (p>0,05).
Kesimpulan: Kadar HE4 pada pasien kanker ovarium lebih tinggi daripada tidak resisten tetapi tidak memprediksi resistensi kanker ovarium berdasarkan status menopause pasien.
Kata kunci : HE4, kanker ovarium, resistensi .
Uji Teknik Difusi Menggunakan Kertas Saring Media Tampung Antibiotik dengan Escherichia Coli Sebagai Bakteri Uji
Authors: Khusuma Ari , Safitri Yuriska , Yuniarni Annisa , Rizki Kurnia 
Published: August 2019

Uji sensitivitas antibiotik merupakan tes yang digunakan untuk menguji kepekaan suatu bakteri terhadap suatu antibiotik. Uji sensitivitas bertujuan untuk mengetahui efektifitas dari suatu antibiotik (Wahyutomo, 2009). Uji sensitivitas dapat dilakukan dengan beberapa cara yaitu: difusi cakram diffusion test), pengenceran atau dilusi (dilusi test), antimicrobial gradient dan short automated instrumen system. Uji sensitivitas dengan metode difusi agar plate dapat dilakukan dengan cara Kirby Bauer dengan teknik disc diffusion (cakram disk) atau teknik sumuran. Rancangan penelitian ini adalah penelitian eksperiment dengan melihat uji difusi menggunakan kertas saring sebagai media tampung antibiotik dengan menggunakan E.coli sebagai bakteri uji. Data yang diperlukan adalah diameter zona hambat yang terbentuk pada media MHA saat melakukan uji sensitivitas metode difusi sumuran dan teknik kertas saring sebagai media tampung antibiotik. Hasil penelitian ini menunjukan bahwa rerata diamater zona hambat antibiotik ciprofloxacin terhadap bakteri E.coli dengan menggunakan metode difusi teknik sumuran adalah 62 mm menunjukan hasil sensitif, rerata diameter zona hambat yang terbentuk dengan menggunakan inovasi uji difusi menggunakan kertas saring sebagai media tampung antibiotik ciprofloxacin adalah 39 mm menunjukan hasil sensitif. Rerata diameter zona hambat yang terbentuk pada inovasi uji difusi menggunakan kertas saring sebagai media tampung antibiotik lebih kecil dibandingkan dengan rerata diameter zona hambat menggunakan metode difusi teknik sumuran. Rata-rata diameter zona hambat antibiotik dengan menggunakan kertas saring sebagai media tampung adalah 39 mm. Perbedaan diameter zona hambat menggunakan teknik sumuran dengan teknik kertas saring sebagai media tampung antibiotik adalah 62 mm dan 39 mm.
Cotidiano alimentar das crianças de escolas de educação infantil: visão dos funcionários
Authors: Ramos Patricia Mergen 
Published: August 2019

Objetivo: Detectar os problemas que dificultam a efetiva educação alimentar e nutricional dentro de escolas de educação infantil. Metodologia: Foram selecionadas 55 mulheres que trabalham em escolas de educação infantil de Esteio. A coleta de dados foi por meio de questionários, um sobre alimentação saudável e o outro sobre hábitos e costumes. Resultados: 86,84% das participantes relataram não apresentarem problemas de saúde. Sobre a educação, pode-se observar que existe uma dependência do grau de instrução com o local pesquisado. Portanto, quanto mais educação mais entendimento sobre o cotidiano alimentar das crianças. Sobre a etnia, foi possí­vel verificar que existe uma diferença entre o observado na pesquisa e o panorama populacional da região, a etnia não influência no cotidiano alimentar das crianças. Conclusão: Há necessidade de capacitação dos profissionais da área da saúde e da pedagogia, assim como auxiliares e proprietários, que possam ter orientações sobre as questões alimentares. Nesse sentido o trabalho multidisciplinar com a presença do profissional nutricionista, para transmissão do conhecimento técnico em relação í alimentação saudável é de suma importância.Palavras-chave: alimentos formulados, alimentos infantis, nutrição da criança.
PENDIDIKAN KRISTIANI MELALUI PENGALAMAN BERKOMUNITAS BAGI ANAK-ANAK
Authors: Wijaya Albert I Ketut Deni 
Published: August 2019

Gereja masa depan tidak bisa terpisah dari mutu pendidikan iman anak-anak saat ini. Untuk itu, sejak dini anak-anak perlu mendapat pendidikan iman yang bermutu sedini mungkin. Hal itu berarti bahwa anak-anak perlu belajar tidak hanya dengan model klasikal namun perlu dengan bentuk yang lain. Melihat hal tersebut, pendidikan yang berangkat dari pengalaman berkomunitas menjadi alternatif yang perlu dipikirkan kembali. Dalam pendidikan pengalaman berkomunitas, setiap pribadi belajar dari pengalaman untuk bersedia saling memberikan diri bagi orang lain dan saling mendukung bagi pertumbuhan dan perkembangan setiap pribadi secara utuh.
Modern aspects of the development of security in air transport under the conditions of air terrorism
Authors: Michalski Daniel , Radomyski Adam 
Published: August 2019

Objectives<i>The authors determined the following aim of this article: identifying threats generated by air terrorism as well as characterizing the forms, methods, and manners.</i>Methods<i>Authors used theoretical methods of research. The article presents research findings with regard to the organization and operation of security systems in civil air transport. At the article, the authors focused on air terrorism and security system in the airport.</i>Results<i>The presented results of the study are not limited only to the theoretical aspects of terrorism. Authors also characterize organizational and technical undertakings that have already been implemented into security systems in aviation by national and intergovernmental institutions, responsible for its protection.</i>Conclusions<i>Regardless of the form of air terrorism and applied means, an important issue is a fact that every attempt to intercept an aerial asset is attractive for terrorists, due to the fact that each time it causes not only damage or destruction of the machine itself and the death of passengers, but it is also a real threat to airport infrastructure, installations and urban residents. In addition, the events are accompanied by high-profile media coverage.</i>
Perbandingan Kadar C-Reactive Protein Pada Penderita Diabetes Melitus Tipe 2 Yang Diterapi Dengan Insulin dan Obat Hipoglikemik Oral di Poliklinik Penyakit Dalam Rumah Sakit Umum Pusat Sanglah Denpasar Bali
Authors: Dwipayana Pande , Saraswati IMR , Suastika K 
Published: August 2019

Latar belakang: Proses inflamasu pada pasien diabetes merupakan salah satu pathogenesis kejadian kardiovaskular. C-reactive protein (CRP) merupakan penanda inflamasi yang dapat digunakan untuk memprediksi penyakit-penyakit kardiovaskular. Data mengenai perbandingan efek insulin dan obat hipoglikemik oral (OHO) dalam menurunkan kaadr CRP masih kurang.
Tujuan: Penelitian ini bertujuan untuk menentukan apakah kadar CRP pada pasien diabetes tipe melitus 2 dengan terapi insulin lebih rendah dibandingkan dengan pasien dengan OHO.
Metode: Penelitian ini merupakan studi potong-lintang analitik yang melibatkan 75 pasien diabetes tipe 2 dengan insulin dan OHO dengan metode consecutive sampling. Kriteria eksklusi meliputi pasien dengan infeksi akut/sepsis, penyakit koroner, keganasan, penyakit ginjal kronik, penyakit hati, pasien yang menjalani terapi radiasi, perokok, dan pasien dengan terapi statin atau fibrat. Data dianalisis dengan t-test tidak berpasangan dan ANCOVA untuk meng-adjust variabel perancu.
Hasil: Sebanyak 35 pasien (52%) dari total 75 pasien menggunakan insulin dan 36 (48%) menggunakan OHO. Rerata kadar CRP pada pasien diabetes tipe 2 yaitu 1,9 ± 2,08 mg/L. Rerata kadar CRP pada kelompok yang menggunakan insulin dan OHO sebesar 1.5 ± 1.78 mg/L dan 2,4 ± 2,30 mg/L (p = 0.04). Setelah penyesuaian terhadap variabel perancu, perbedaan kadar CRP antara kelompok yang menggunakan insulin dan OHO tetap signifikan (p = 0.02).
Simpulan: Kadar CRP pada pasien diabetes tipe 2 dengan terapi insulin lebih rendah secara signifikan dibandingkan dengan menggunakan OHO.
Kadar hemoglobin awal sebagai faktor prognostik penderita limfoma non-hodgkin (LNH) yang menjalani kemoterapi
Authors: Winarto Daniel , Rena Ni Made Renny A , Adnyana Wayan Losen , Dharmayuda Tjokorda Gede , Suega Ketut , Bakta I Made 
Published: August 2019

Latar belakang: Anemia sering ditemukan pada saat diagnosis awal LNH. Anemia dapat terjadi karena beberapa kondisi, seperti perdarahan terkait LNH dengan atau tanpa anemia defisiensi besi, anemia karena penyakit kronik, infiltrasi sel-sel LNH ke sumsum tulang, anemia hemolitik autoimun maupun anemia terkait kemoterapi. Anemia mempengaruhi perjalanan klinis dan kesintasan pasien-pasien LNH.
Tujuan: Penelitian ini bertujuan untuk membuktikan bahwa kadar Hb awal merupakan faktor prognostik penderita LNH yang menjalani kemoterapi.
Metode: Penelitian ini merupakan penelitian kohort retrospektif mulai bulan Januari 2013 sampai bulan September 2017 pada penderita LNH yang menjalani kemoterapi di RSUP Sanglah Denpasar. Hubungan antara kadar Hb dengan skor R-IPI dianalisis menggunakan uji Mann Whitney. Analisis kesintasan menggunakan metode Kaplan Meier dan Cox Proportional Hazard Mode dengan menggunakan software SPSS.
Hasil: Dari 88 penderita LNH, dieksklusi 31 penderita, sehingga total sampel sebanyak 57 orang. Dengan menggunakan analisis komparatif Mann Whitney didapatkan perbedaan signifikan pada skor R-IPI antara pasien LNH dengan Hb ≥ 10 g/dl (md=1, n=46) dan kadar Hb < 10 g/dl (md=3, n=11) (z= -2,106; p= 0,035; d= 0,28). Analisis dengan Kaplan Meier, didapatkan penderita dengan kadar Hb<10 gram/dL memiliki kesintasan lebih pendek dibanding penderita dengan kadar Hb≥10 gram/dL (± 255 vs ± 850 hari; p= 0,002; IK 95%) dan dengan analisis Cox Regression didapatkan Hazard ratio sebesar 4.46 (p= 0,005).
Simpulan: Kadar hemoglobin awal dapat digunakan sebagai faktor prognostik mortalitas penderita LNH yang menjalani kemoterapi.
Presolar Silicon Carbide Grains of Types Y and Z: Their Molybdenum Isotopic Compositions and Stellar Origins
Authors: Liu Nan , Stephan Thomas , Cristallo Sergio , Gallino Roberto , Boehnke Patrick , Nittler Larry R. , Alexander Conel M. O’D. , Davis Andrew M. , Trappitsch Reto , Pellin Michael J. , Dillmann Iris 
Published: August 2019

Abstract
We report Mo isotopic compositions of 37 presolar SiC grains of types Y (19) and Z (18), rare types commonly argued to have formed in lower-than-solar metallicity asymptotic giant branch (AGB) stars. Direct comparison of the Y and Z grain data with data for mainstream grains from AGB stars of close-to-solar metallicity demonstrates that the three types of grains have indistinguishable Mo isotopic compositions. We show that the Mo isotope data can be used to constrain the maximum stellar temperatures (T
MAX) during thermal pulses in AGB stars. Comparison of FRUITY Torino AGB nucleosynthesis model calculations with the grain data for Mo isotopes points to an origin from low-mass (∼1.5–3 M
⊙) rather than intermediate-mass (>3–∼9 M
⊙) AGB stars. Because of the low efficiency of 22Ne(α, n)25Mg at the low T
MAX values attained in low-mass AGB stars, model calculations cannot explain the large 30Si excesses of Z grains as arising from neutron capture, so these excesses remain a puzzle at the moment.
The Climates of Other Worlds: A Review of the Emerging Field of Exoplanet Climatology∗
Authors: Shields Aomawa L. 
Published: August 2019

Abstract
The discovery of planets orbiting stars other than the Sun has accelerated over the past decade, and this trend will continue as new space- and ground-based observatories employ next-generation instrumentation to search the skies for habitable worlds. However, many factors and processes can affect planetary habitability and must be understood to accurately determine a planet’s habitability potential. While climate models have long been used to understand and predict climate and weather patterns on the Earth, a growing community of researchers has begun to apply these models to extrasolar planets. This work has provided a better understanding of how orbital, surface, and atmospheric properties affect planetary climate and habitability; how these climatic effects might change for different stellar and planetary environments; and how the habitability and observational signatures of newly discovered planets might be influenced by these climatic factors. This review summarizes the origins and evolution of the burgeoning field of exoplanet climatology, discusses recent work using a hierarchy of computer models to identify those planets most capable of supporting life, and offers a glimpse into future directions of this quickly evolving subfield of exoplanet science.
Shattering of Cosmic Sheets due to Thermal Instabilities: A Formation Channel for Metal-free Lyman Limit Systems
Authors: Mandelker Nir , van den Bosch Frank C. , Springel Volker , van de Voort Freeke 
Published: August 2019

Abstract
We present a new cosmological zoom-in simulation, where the zoom region consists of two halos with virial mass M
v ∼ 5 × 1012
M
⊙ and an approximately megaparsec long cosmic filament connecting them at z ∼ 2. Using this simulation, we study the evolution of the intergalactic medium in between these two halos at unprecedented resolution. At 5 ≳ z ≳ 3, the two halos are found to lie in a large intergalactic sheet, or “pancake,” consisting of multiple coplanar dense filaments along which nearly all halos with M
v > 109
M
⊙ are located. This sheet collapses at z ∼ 5 from the merger of two smaller sheets. The strong shock generated by this merger leads to thermal instabilities in the postshock region, and to a shattering of the sheet resulting in ≲ kiloparsec-scale clouds with temperatures of T ≳ 2 × 104 K and densities of n ≳ 10−3 cm−3, which are pressure confined in a hot medium with T ∼ 106 K and n ≳ 10−5 cm−3. When the sheet is viewed face-on, these cold clouds have neutral hydrogen column densities of N
H i
> 1017.2 cm−2, making them detectable as Lyman limit systems, though they lie well outside the virial radius of any halo and even well outside the dense filaments. Their chemical composition is pristine, having zero metallicity, similar to several recently observed systems. Since these systems form far from any galaxies, these results are robust to galaxy formation physics, resulting purely from the collapse of large-scale structure and radiative cooling, provided sufficient spatial resolution is available.
TESS Spots a Compact System of Super-Earths around the Naked-eye Star HR 858
Authors: Vanderburg Andrew , Huang Chelsea X. , Rodriguez Joseph E. , Becker Juliette C. , Ricker George R. , Vanderspek Roland K. , Latham David W. , Seager Sara , Winn Joshua N. , Jenkins Jon M. , Addison Brett , Bieryla Allyson , Briceño Cesar , Bowler Brendan P. , Brown Timothy M. , Burke Christopher J. , Burt Jennifer A. , Caldwell Douglas A. , Clark Jake T. , Crossfield Ian , Dittmann Jason A. , Dynes Scott , Fulton Benjamin J. , Guerrero Natalia , Harbeck Daniel , Horner Jonathan , Kane Stephen R. , Kielkopf John , Kraus Adam L. , Kreidberg Laura , Law Nicolas , Mann Andrew W. , Mengel Matthew W. , Morton Timothy D. , Okumura Jack , Pearce Logan A. , Plavchan Peter , Quinn Samuel N. , Rabus Markus , Rose Mark E. , Rowden Pam , Shporer Avi , Siverd Robert J. , Smith Jeffrey C. , Stassun Keivan , Tinney C. G. , Wittenmyer Rob , Wright Duncan J. , Zhang Hui , Zhou George , Ziegler Carl A. 
Published: August 2019

Abstract

Transiting Exoplanet Survey Satellite (TESS) observations have revealed a compact multiplanet system around the sixth-magnitude star HR 858 (TIC 178155732, TOI 396), located 32 pc away. Three planets, each about twice the size of Earth, transit this slightly evolved, late F-type star, which is also a member of a visual binary. Two of the planets may be in mean motion resonance. We analyze the TESS observations, using novel methods to model and remove instrumental systematic errors, and combine these data with follow-up observations taken from a suite of ground-based telescopes to characterize the planetary system. The HR 858 planets are enticing targets for precise radial velocity observations, secondary eclipse spectroscopy, and measurements of the Rossiter–McLaughlin effect.
LOFAR Discovery of a Radio Halo in the High-redshift Galaxy Cluster PSZ2 G099.86+58.45
Authors: Cassano R. , Botteon A. , Gennaro G. Di , Brunetti G. , Sereno M. , Shimwell T. W. , Weeren R. J. van , Brüggen M. , Gastaldello F. , Izzo L. , Bîrzan L. , Bonafede A. , Cuciti V. , Gasperin F. de , Röttgering H. J. A. , Hardcastle M. , Mechev A. P. , Tasse C. 
Published: August 2019

Abstract
In this Letter, we report the discovery of a radio halo in the high-redshift galaxy cluster PSZ2 G099.86+58.45 (z = 0.616) with the LOw Frequency ARray (LOFAR) at 120–168 MHz. This is one of the most distant radio halos discovered so far. The diffuse emission extends over ∼1 Mpc and has a morphology similar to that of the X-ray emission as revealed by XMM-Newton data. The halo is very faint at higher frequencies and is barely detected by follow-up 1–2 GHz Karl G. Jansky Very Large Array observations, which enable us to constrain the radio spectral index to be α ≲ 1.5–1.6, i.e., with properties between canonical and ultra-steep spectrum radio halos. Radio halos are currently explained as synchrotron radiation from relativistic electrons that are re-accelerated in the intracluster medium by turbulence driven by energetic mergers. We show that in such a framework radio halos are expected to be relatively common at ∼150 MHz (∼30%–60%) in clusters with mass and redshift similar to PSZ2 G099.86+58.45; however, at least two-thirds of these radio halos should have a steep spectrum and thus be very faint above ∼1 GHz frequencies. Furthermore, because the luminosity of radio halos at high redshift depends strongly on the magnetic field strength in the hosting clusters, future LOFAR observations will also provide vital information on the origin and amplification of magnetic fields in galaxy clusters.
Avaliação estratégica da produtividade acadêmica de docentes de cursos de graduação
Authors: Cesso Marcus Vinicius , Ferraz Renato Ribeiro Nogueira 
Published: August 2019

As Instituições de Ensino Superior (IES) brasileiras têm seus cursos de graduação avaliados pelo Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), periodicamente. Entre os critérios definidos, destaca-se a dimensão Corpo Docente e Tutorial, que corresponde a 30% da nota total dos cursos de graduação. Assim, o estudo utiliza a ferramenta computacional Scriptemec para a avaliação contínua e automatizada da produção acadêmica dos cursos de graduação em Enfermagem e Medicina, de uma IES particular. Com o uso de uma metodologia mista de pesquisa, foram avaliados os critérios de produtividade acadêmica, como produção bibliográfica, produção técnica, e popularização dos resultados das pesquisas realizadas pelos docentes da instituição, de forma quantitativa e qualitativa, permitindo uma análise longitudinal dos dados em um longo período de tempo. Como contribuição do presente estudo, reforça-se a possibilidade do estudo do desempenho acadêmico em pesquisa de docentes de cursos de graduação com o apoio de uma ferramenta estratégica de livre acesso e que permite uma otimização na análise de indicadores de produtividade intelectual, além da construção de um dashboard automatizado com os dados de produtividade acadêmica dos docentes, possibilitando o acompanhamento contínuo destes indicadores para prestação de contas ao INEP e avaliação interna da instituição.
Comparison of equatorial wave activity in the tropical tropopause layer and stratosphere represented in reanalyses
Authors: Kim Young-Ha , Kiladis George N. , Albers John R. , Dias Juliana , Fujiwara Masatomo , Anstey James A. , Song In-Sun , Wright Corwin J. , Kawatani Yoshio , Lott François , Yoo Changhyun 
Published: August 2019

Abstract. Equatorial Kelvin and mixed Rossby–gravity (MRG) waves in the tropical tropopause layer and stratosphere represented in recent reanalyses for the period of 1981–2010 are compared in terms of spectral characteristics, spatial structures, long-term variations, and their forcing of the quasi-biennial oscillation (QBO).
For both wave types, the spectral distributions are broadly similar among most of the reanalyses, while the peak amplitudes exhibit considerable spread.
The longitudinal distributions and spatial patterns of wave perturbations show reasonable agreement between the reanalyses.
A few exceptions to the similarity of the spectral shapes and spatial structures among them are also noted.
While the interannual variations of wave activity appear to be coherent for both the Kelvin and MRG waves, there is substantial variability in long-term trends among the reanalyses.
Most of the reanalyses which assimilate satellite data exhibit large increasing trends in wave variance (∼15 %–50 % increase in 30 years at 100–10 hPa), whereas one reanalysis (Japanese 55-year Reanalysis assimilating conventional observations only; JRA-55C) produced without satellite data does not.
Several discontinuities are found around 1998 in the time series of the Kelvin and MRG wave variances, which manifest in different ways depending on the reanalysis, and are indicative of impacts of the transition of satellite measurements during that year.
The equatorial wave forcing of the QBO, estimated by the Eliassen–Palm (EP) flux divergence, occurs in similar phase-speed ranges in the lower stratosphere among the reanalyses.
However, the EP flux and its divergence are found to be dependent on the zonal-mean winds represented in reanalyses, exhibiting different magnitudes, altitudes, and phase-speed ranges of the Kelvin wave forcing between the reanalyses, especially at 20–10 hPa.
In addition, at around 20 hPa, a wave signal which appears only in easterly mean winds with westward phase speeds is found and discussed.