bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased miR-486-5p is involved in lipopolysaccharide-induced HTR-8/SVneo cell dysfunction by promoting SMAD2 expression
Authors: Gu Yan , Chen Ling-Han , Yang Long , Shi Yan , Xu Hao-Lan , Xin Ya-Wei , Song Ning , Gu Wen-Wen , Wang Jian 
Published: October 2024

In briefInsufficiency of extravillous trophoblast (EVT) cell invasion is implicated in pregnancy complications. This study reveals the roles of the miR-486-5p/Smad2 pathway in lipopolysaccharide (LPS)-induced EVT dysfunctions and in the pathogenesis of early pregnancy loss (EPL).AbstractPlacenta-associated pathologies, including EPL and preeclampsia, are characterized by insufficient EVT invasion. Previously, downregulated miR-486-5p expression was shown to inhibit the invasion of EVTs, and decreased peripheral miR-486-5p expression was associated with EPL. However, the exact roles of miR-486-5p in the pathogenesis of EPL, as well as the molecular pathway underlying the role of miR-486-5p in EVT invasion, remain poorly understood. In this study, decreased miR-486-5p expression in the uterine embryo implantation site on gestational day 8.5 and increased uterine expression of Smad2, a target of miR-486-5p, were observed in an LPS-induced EPL model. The invasion and viability of the immortalized human EVT line, HTR-8/SVneo, were inhibited by LPS, accompanied by reduced miR-486-5p expression. LPS promoted Smad2 expression, which was attenuated by the miR-486-5p mimics. The downregulation of Smad2 effectively restored the impaired invasion and viability of HTR-8/SVneo cells caused by LPS or the miR-486-5p inhibitor. Furthermore, LPS promoted TNFα production in HTR-8/SVneo cells, whereas both siSMAD2 and miR-486-5p mimics reversed this effect. An analysis of human decidua single-cell RNA sequencing and transcriptome datasets derived from Gene Expression Omnibus revealed that, compared with that in control early pregnant women, SMAD2 expression was significantly increased in recurrent miscarriage patients. Collectively, these data suggest that decreased miR-486-5p expression might lead to EPL, at least partially by inhibiting invasion and/or promoting TNFα production in EVTs by targeting SMAD2.
Pancreatic Ultrasound in High-risk Neonates
Authors: ELMeneza Safaa A. , Hassan Naglaa F. , Mohamed Aisha R. 
Published: October 2024

Pancreatic ultrasound is employed to assess the structure of the organ and diagnose various conditions. However, analyses of pancreatic images of high-risk newborn infants are scarce.Aim of the study: to investigate pancreatic echogenicity in high-risk neonates and evaluate the association between pancreatic echogenicity and clinical diagnosis.Materials and methods. This prospective observational case-control ultrasound study included 105 neonates admitted to the neonatal intensive care unit or outpatient. The patients were divided into two groups: group 1 (high-risk), which included 55 high-risk neonates, and group 2 (control), which included 50 neonates of comparable age with no history of high-risk pregnancy or delivery who were presented for medical consultation. Abdominal ultrasound examinations were performed, with a focus on the pancreas. Pancreatic echogenicity was classified as hyperechoic, isoechoic, or hypoechoic, relative to the liver.Results. No significant difference in pancreatic size was observed between the high-risk and control groups. A significant predominance of hyperechogenicity over hypoechogenicity or isoechogenicity was found in the high-risk group. A significant difference in echogenicity was found between the high-risk and control groups (P=0.0001). Neonates in the control group were more likely to have pancreatic isoechogenicity (60%) compared to hyperechogenicity (34%) or hypoechogenicity (6%). In the high-risk group, neonates had a higher frequency of pancreatic hyperechogenicity (72.72%) compared to hypoechogenicity (10.9%) or isoechogenicity (16.36%). Notably, 83.3% of infants born to diabetic mothers had a hypoechogenic pattern. Certain high-risk infants, such as preterm infants and those with perinatal asphyxia, had a higher frequency of hyperechogenicity (83.3%). The percentage of hypoechoic pattern was comparable in male and female newborns (50%); isoechoic pattern was more prevalent in females (77.3%) than in males (22.2%), while males had a more frequent hyperechoic pattern (57.5%).Conclusion. Evaluation of the pancreas in high-risk neonates and monitoring of long-term outcomes are of critical importance, especially in the infants of diabetic mothers.
Procedural Complications of Central Venous Catheter Placement in Pediatric Oncology Practice (a Clinical Case Series)
Authors: Shchukin Vladislav V. , Leonov Nikolay P. , Spiridonova Elena A. , Selivanov Vladimir V. , Dergunova Ekaterina V. , Novichkova Galina A. , Myakova Natalia V. , Grachev Nikolay S. , Bykov Mikhail V. , Bystrova Anastasia A. , Grigoryan Rina S. , Matinyan Nune V. , Petrushin Anton V. , Loaisa Hugo 
Published: October 2024

The availability of central venous access is the cornerstone of contemporary pediatric oncology and hematology. As a result, the percentage of pediatric patients receiving infusion chemotherapy who require a central line remains high. Central venous catheter insertion can be associated with procedural complications, including life-threatening ones.Aim — to investigate the potential factors leading to complications during central venous catheterization in order to develop preventive strategies.Materials and methods. The study included 1,512 original cases of patients aged 1 month to 20 years treated at the D. Rogachev National Research Medical Center between 2019 and 2022. The following 10 complications were examined: failed first venipuncture attempt, guidewire/catheter malpositioning, guidewire knotting, lifethreatening arrhythmias, guidewire entrapment in the trabecular network of the right ventricle, arterial puncture, pneumothorax, hemothorax, puncture of lung parenchyma, Horner's syndrome. In addition, four rare complications were noted, including phrenic nerve injury, cardiac tamponade, alveolar hemorrhage, and arterial pseudoaneurysm.Results. The primary cause of all complications was direct mechanical injury to anatomical structures by a needle or guidewire/catheter. When inadvertent vascular injury and bleeding occur, the resulting hematoma may lead to further damage by compressing soft tissues. Excessively deep insertion of the guidewire may cause its knotting or cardiac arrhythmias. Adequate physician training and strict adherence to procedural protocols are essential to avoid these complications.Conclusion. Central venous catheterization remains a procedure with potential complications. Although ultrasound guidance does not eliminate all risks, it increases the likelihood of successful venipuncture at the first attempt, thereby reducing complication rates. Recognizing the potential causes of procedural complications during central venous access placement, including uncommon ones, facilitates early diagnosis and appropriate medical intervention.
Effective Ventilation Mode in Early Neonatal Sepsis, Bilateral Pneumonia, and Pulmonary Hypertension in a Very Low Birth Weight Newborn (Case Report)
Authors: Lukashev Konstantin V. , Nuzhdin Alexander I. , Emikh Alexey T. , Grishina Anna N. , Zorina Elena B. , Shleicher Nikolay V. , Kan Sergey L. , Kovaleva Yulia V. 
Published: October 2024

The aim was to demonstrate an alternative approach to respiratory therapy in respiratory failure complicated by pulmonary hypertension when conventional ventilation and high-frequency oscillatory ventilation are ineffective.Patient and study methods. We analyzed laboratory data, ventilatory parameters and hemodynamic parameters during ventilation in a child with birth weight of 1300 grams and respiratory failure complicated by pulmonary hypertension. Dynamic selection of parameters and modes of pulmonary ventilation with transition to Airway Pressure Release Ventilation (APRV) mode is presented. Chest radiography and echocardiography were used.Results. The use of APRV mode when traditional approaches were ineffective allowed «stabilization» of the lungs by alveolar recruitment without deep sedation and muscle relaxation. On day 20 after birth, the infant was weaned. On day 29, the infant was transferred to the neonatal pathology unit for further management, and on day 49, the infant was discharged in stable condition.Conclusion. In neonates with severe respiratory failure, the use of the APRV mode as an alternative to ineffective conventional ventilation requires further investigation and the development of guidelines for its use.
The Effect of Extracorporeal Membrane Oxygenation in the Management of Refractory Ventricular Tachycardia Developed after Fontan Procedure (Case Report)
Authors: Anikina Olga S. , Soynov Ilya A. , Velyukhanov Ilya A. , Suzdalova Olga A. , Kulyabin Yuri Yu. , Sergeev Stanislav A. , Arkhipov Alexey N. , Kornilov Igor A. 
Published: October 2024

Aim: to evaluate the effect of extracorporeal membrane oxygenation (ECMO) as a life support in the treatment of a patient with refractory ventricular tachycardia developed after Fontan procedure. Patient and treatment. A 4-year-old child developed refractory ventricular tachycardia (up to 250 bpm) and hemodynamic depression 18 hours after the Fontan procedure. After the failure of cardiopulmonary resuscitation and antiarrhythmic therapy, resternotomy with central venoarterial (VA) ECMO support was performed, followed by diagnostic angiocardiography. Contrast-enhanced cavopulmonary angiography revealed stenosis of the left pulmonary artery, which was treated with balloon angioplasty and stenting.Results. Ventricular tachycardia resolved and sinus rhythm was restored within 24 hours after left pulmonary artery stenting, supported by continuous ECMO and antiarrhythmic therapy. On day 3, transthoracic echocardiography showed good single ventricle contractility after a trial weaning from ECMO. As a result, the ECMO support was removed and the sternum sutured. The patient was discharged from the hospital on day 47 in stable condition.Conclusion. The prompt initiation of VA ECMO support in a 4-year old patient with refractory ventricular tachycardia post-Fontan procedure along with the complex management of post-procedural residual tachycardia using a combination of antiarrhythmic agents helped restoring sinus rhythm and could contribute to preventing neurological complications.
Replicative co-infections with human immunodeficiency virus 1 and 2 as well as hepatitis B and C virus in Ghanaian individuals
Authors: Glyschewski Lynn , Hahn Andreas , Rohde Holger , Lütgehetmann Marc , Feldt Torsten , Sarfo Fred Stephen , Phillips Richard Odame , Dompreh Albert , Asibey Shadrack Osei , Boateng Richard , Weinreich Felix , Frickmann Hagen , Eberhardt Kirsten Alexandra 
Published: October 2024

AbstractBackgroundThe study assessed replicative human immunodeficiency virus-(HIV-) infection and replicative co-infections as well as molecular determinants of reduced susceptibility towards anti-retroviral therapy in a Ghanaian population of known HIV patients and a control group.MethodsReal-time PCRs for HIV-1, HIV-2, hepatitis B virus (HBV) and hepatitis C virus (HCV) were run with serum samples from known Ghanaian HIV-patients (n = 975) and control individuals (n = 105). For 108 individuals, HIV-sequence analysis was performed.ResultsPrevalence of replicative HIV-1 infection was 59.8% (583/975) in the known HIV-positive population and 2.9% (3/105) in the controls. Prevalences of replicative HBV-infection were comparable with 3.4% (33/975) in the HIV-positive individuals and 3.8% (4/105) in the controls. HIV-2 and HCV sequences were not recorded. Almost perfect concordance between two compared HIV-1-PCR assays was indicated by Fleiss' Kappa >0.8. Sanger sequencing indicated CRF_02AG, G and A3 as the quantitatively dominating HIV-1 subtypes, a minority of 3.4% CXCR4 tropism and high detection rates of mutations mediating reduced susceptibility towards nucleoside reverse transcriptase inhibitors (71.9%, 64/89), non-nucleoside reverse transcriptase inhibitors (95.5%, 85/89), protease inhibitors (95.9%, 93/97) and integrase inhibitors (22.4%, 22/98).ConclusionsThe assessment did not suggest HIV-triggered increased replication of HBV and HCV in the investigated Ghanaian population.
Longitudinal trait and state-like differences in the components model of addiction: An illustration through social media addiction and work addiction
Authors: Horváth Zsolt , Kun Bernadette , Király Orsolya , Paksi Borbála , Griffiths Mark D. , Demetrovics Zsolt 
Published: October 2024

AbstractBackground and aimsConflicting findings have been reported for the longitudinal course of behavioral addictions, especially for social media addiction (SMA) and work addiction (WA). Therefore, evaluating whether these constructs are more trait-like or state-like might be informative. The aim of the present study was to examine the proportion of variance of SMA and WA symptoms (as defined by the components model of addiction) explained by trait and occasion-specific factors in addition to exploring cross-lagged relationships between SMA and WA.MethodsYoung adults from a representative sample who continuously used social media and worked at least 40 hours a week during the first three waves of the Budapest Longitudinal Study were included (N = 1,551; Females: 50.6%; Age: M = 27.7 years [SD = 4.40]). The Bergen Social Media Addiction Scale and the Bergen Work Addiction Scale were administered in all three waves.ResultsA latent state-trait model with a general trait factor was considered for both SMA and WA. Symptomatic variability in SMA was explained approximately equally by trait and state-like factors, while WA-related symptom variability was mostly attributed to state-like factors. SMA negatively predicted WA over time, while WA showed a positive cross-lagged effect on SMA.Discussion and ConclusionsWhile the symptoms of WA were more state-like, the trait-like effects were stronger in SMA. Situational influences and previous symptom severities might have to be considered in the screening process.
Attack efficiency in first league men’s volleyball for playing positions, according to the value level of the teams
Authors: Mocanu George Danut , Harabagiu Neculai , Parvu Carmen 
Published: October 2024

Background and Study Purpose. The attack is a crucial technical element in scoring points in volleyball. This research aims to identify differences in attack efficiency and errors based on the value level of teams in the competitive system, considering different playing positions.
Material and Methods. The analysis included 86 attacking players from the rosters of 12 teams in the men’s domestic first league. The distribution by positions was as follows: 37 outside hitters, 19 opposites, and 30 middle blockers. Statisticians from each team recorded the data using Data Volley software during three championship matches. For each player, the following parameters were interpreted: Attack Efficiency (E%), Error% (=), Blocked Attack% (/), Poor% (-), Blocked but Recovered% (!), Positive% (+), and Winning% (#). Attack efficiency was analyzed for each playing position across top teams (positions 1-4 in the final ranking), mid-level teams (positions 5-8), and lower-level teams (positions 9-12).
Results. Across all three playing positions, top teams demonstrate higher percentages in attack efficiency, winning executions, and positive outcomes compared to average and lower-level teams. Top and average teams also have lower percentages of errors in attack executions. For the outside hitter position, no statistically significant superiority is observed between top and middle teams for any attack variable, indicating a balance in player performance. In the opposite hitter position, top and middle-level players show higher attack efficiency and direct point scores (Winning). They also have lower poor execution rates, despite the lack of statistical confirmation for superiority in many attack variables. Among all positions, top middle blockers exhibit a clear superiority over low-level teams across all attack variables.
Conclusions. The findings of the study highlight the critical role of team value level in influencing attack efficiency and execution quality across different playing positions in volleyball. The results underscore the importance of strategic differentiation in training and game planning. This is especially crucial for teams aiming to optimize their performance. Coaches and trainers should focus on tailored approaches that address the specific strengths and weaknesses of each playing position. They should also consider the overall team value level in their strategies. This approach could lead to improved competitive outcomes and a more effective utilization of player potential across all levels of competition.
Unmasking population undercounts, health inequities, and health service access barriers across Indigenous populations in urban Ontario
Authors: Snyder Marcie , McConkey Stephanie , Brar Raman , Anilniliak Judy , Bourgeois Cheryllee , Dokis Brian , Hardy Michael , Joseph Serena , Kilabuk Amanda , Mattina Jo-Ann , McKnight Constance , Smylie Janet 
Published: October 2024

Abstract
Objectives
Our Health Counts (OHC) methods are designed to address gaps in urban-based Indigenous health information. In partnership with local Indigenous health service providers, we have successfully implemented OHC in six Ontario cities. The aim of this study is to summarize findings regarding Indigenous population undercount, health inequities, and health service access barriers across study sites.

Methods
We estimated Indigenous population size using OHC census participation survey responses and a multiplier approach. Health inequities between Indigenous populations and overall populations in each city were examined using respondent-driven sampling (RDS), adjusted OHC survey results, and existing public data. Measures included health status outcomes; determinants of health; barriers to health service access, including discrimination by health service providers; and unmet health needs.

Results
Indigenous social networks were strong and extensive, and the urban populations demonstrate resilience and cultural continuity across multiple measures. Self-reported rates of census participation for Indigenous populations were markedly lower than those for the general population in each city, and OHC Indigenous population size estimates were consistently 2‒4 times higher than reported in the census. Indigenous to general population health inequities cut across measures of chronic disease, determinants of health, and unmet health needs. Indigenous populations experienced multiple barriers to health services access, including racial discrimination by health service providers.

Conclusion
The Canadian census appears to markedly underestimate Indigenous population size in urban areas. Indigenous health inequities and service access barriers are striking and cross-cutting. Timely adaptation of health policies, services, and funding allocations in response to these findings is recommended.
О ПРИНЦИПАХ КОРПОРАТИВНОГО УПРАВЛЕНИЯ В РОССИЙСКИХ КОММЕРЧЕСКИХ БАНКАХ
Authors: А.О. Перин 
Published: October 2024

Статья посвящена анализу систем корпоративного управления в российских банках, его особенностям и перспективам улучшения. Соблюдение высоких стандартов корпоративного управления в сфере банковской деятельности может способствовать укреплению устойчивости всей банковской системы страны. В работе рассматривается существующая система корпоративного управления в банковском секторе России, выявляются проблемные аспекты и идентифицируются ключевые вызовы, стоящие перед отечественными банками в рассматриваемой сфере. Автором рассматриваются основные принципы корпоративного управления и предлагаются рекомендации по повышению его эффективности в российских банках.
The article focuses on the analysis of corporate governance systems in Russian banks, its peculiarities, and prospects for improvement. Compliance with high standards of corporate governance in banking activities can contribute to strengthening the sustainability of the entire banking system of the country. The paper examines the existing system of corporate governance in the Russian banking sector, reveals problematic aspects and identifies key challenges facing domestic banks in this area. The author considers the main principles of corporate governance and offers recommendations to improve its efficiency in Russian banks.
THE USE OF MAGIC AS AN ALTERNATIVE TOOL TO TEACH ENGLISH TO YOUNG CHILDREN
Authors: ARCHILA YURANNI MARCELA ROMERO 
Published: October 2024

Lamagia y las clases de inglés parecen ser dos actividades completamente diferentes ya que se piensa que la magia es unaalternativa de diversión y el inglés es visto por algunos como una asignatura escolar, sin embargo, es posible conectar estos dos aspectos y usar las ilusiones mágicas con fines pedagógicos y de esta manera crear un ambiente positivo de aprendizaje donde los niños interactúen usando la lengua extranjera y a la vez se diviertan. Este estudio pretende averiguar los aspectos positivos y negativos y a la vez, analizarcómo funciona lamagia en el salón de clase.
Somewhere
Authors: Salamanca Fredy 
Published: October 2024

Es difícil respirar, el aire pesa, es húmedo, el sol brilla y un ligero vapor sale del pavimento. Suena el timbre, todos corren de un lado a otro a buscar sus morrales para ir a casa. Se abre la puerta del edificio, el calor exter o invade todo el cuerpo, se camina en medio de un lugar diferente, hay densos árboles en las calles, las ardillas deambulan por cualquier lugar, los autos avanzan lentamente por las anchas vías y esperan la inesperada aparición de un peatón para detenerse suavemente y cederle el paso, la fila de casas triangulares se extienden a lado y lado de la calle.
Dialogue Journals: A Pedagogical Strategy to Analyze Students‘ English Writing Development
Authors: Ramos Holguín Bertha , Quintero Calderón Erika , Moreno Novoa Nathalia Ximena 
Published: October 2024

AbstractThis paper reports on the findings of a small - scale research project carried out in apublic school in Tunja, Boyacá, Colombia. It aims at analyzing how students’ Englishwriting was developed through dialogue journals. Data collection instrumentsincluded students’ journals, interviews and teachers´ observation formats. Findingsrevealed that students developed English writing by following models and using codeswitching as a communicative strategy. Key words: Dialogue journals, writing, strategiesResumenEste documento reporta los resultados de un proyecto de investigación a menorescala, llevado a cabo en un colegio público en Tunja, Boyacá, Colombia. Losinstrumentos que se utilizaron para recolectar información incluyeron diarios delos estudiantes, una entrevista y formatos de observación. Los resultados mostraronque la escritura en inglés de los estudiantes se desarrolló a través de seguir modelos yutilizar el cambio de código como estrategia comunicativa.Palabras clave: Diarios de dialogo, escritura, estrategias
L’intégration du Français Familier en Cours de Français Langue Etrangère
Authors: Díaz Benavides Diana , Philippe Nicolas 
Published: October 2024

RésuméL´une des façons qui fait que la réalité de la langue se manifeste est à travers lesexpressions utilisées par les personnes natives pour décrire des situationsparticulières au sein d’un même contexte. Dans ce sens, le langage familier seconvertit, non seulement en un environnement culturel, sinon également en un échantillon des capacités innovatrices et créatives de l’être humain, en tant qu’auteur de formes du langage. Dans cet article, j’expliquerai la méthodologie utilisée par un professeur natif avec une classe de français de quatrième semestre de Licence en Langues Etrangères, afin d’illustrer la réalitéde sa langue maternelle, à travers l’utilisation de ressources écrites (telles queles fables et le journal) et audiovisuelles (la télévision).Mots clés: Langage familier, registre de langue soutenu, registre de langue familier et courant.