bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Geophysical Study of Major Basins in the Pranhita–Godavari Rift, India and Rio Grande Rift, USA
Authors: V. Naga Lakshmi , T. Vani , G.R. Keller , M.V.R.K. Rao , K.V. Subbarao 
Published: December 2024

ABSTRACT
In this study, we compare and contrast two major sub-basins in the Pranhita-Godavari rift in eastern India (Chintalapudi subbasin) and the Rio Grande rift in the western United States (Albuquerque basin) using bouguer gravity data analysis and integrated profile modeling constrained with seismic, drilling, and geological data. The Chintalapudi sub-basin formed during the break-up of Gondwana around 350 Ma, while the Albuquerque basin formed much later (30–35 Ma) in the interior of North America approximately synchronous with extension in the Basin and Range province. The Chintalapudi sub-basin is narrow and deep; and associated with a −60 mGal (low) gravity anomaly that is mostly due to Gondwana fluvial sediments of late Carboniferous (~350 Ma) to early Cretaceous age (~120 Ma). The negative gravity anomaly associated with the Albuquerque basin is −55 mGals (low) and the Cenozoic sediments were deposited on Mesozoic and Palaeozoic strata with Precambrian crystalline rocks being exposed along the basin flanks. This sub-basin is wide and shallow. Major faults which bound these basins were delineated by gravity modeling that integrated all of the available constraints, and the average depth to the basement at the basin centers calculated from gravity modeling is 4–5 km. However, for Chintalapudi sub-basin, if the residual gravity anamoly is considered, it may be reduced to about 3.5 km.
Base-level and Litho-structural Controls on the Incised Sinuous Bedrock Rivers of the Jawhar Plateau, North Konkan, India
Authors: Patil Archana D. , Hire Pramodkumar S. , Kale Vishwas S. 
Published: December 2024

ABSTRACT
The coastal rivers draining the mid-altitude Jawhar Plateau in north Konkan display some unusual drainage and channel characteristics. These rivers, especially in their middle reach, are highly sinuous and deeply incised in bedrock basalt. In this study, various geomorphic indices were calculated and interpreted for five such bedrock meandering rivers, namely Purna, Ambika, Auranga, Par and Damanganga. Morphometric data reveal that in spite of more drainage basin area in the mid-elevation category, the rivers are not only deeply entrenched within bedrock basalt, but also have unusually high sinuosity. There are indications of subtle to significant control of dykes and lineaments on the channel planform morphology and channel bed profile. However, various other geomorphic evidences suggest that an increase in the regional slope, induced by a fall in the erosional base-level, has most likely played an important role on longer timescale in the initiation and formation of the incised bedrock meanders in this part of the Deccan Traps region.
The Effect of a Yoga Lifestyle on QRISK3 Score Among Individuals at High Risk for Cardiovascular Disease
Authors: Saboo Neha , Rao Aayushee , Kacker Sudhanshu 
Published: December 2024

Abstract
Cardiovascular disease is a major cause of mortality and morbidity, and symptoms may not always be visible. Improved preventive strategies could reduce the burden of disease. Yoga is an accessible, affordable lifestyle modification program that has been shown to reduce cardiometabolic risk factors in individuals at high risk for cardiovascular disease. The present randomized controlled trial aimed to evaluate the effect of a yoga lifestyle encompassing diet on QRISK3 score in individuals at high risk for cardiovascular disease. For 6 months, participants (mean age 48.43 ± 6.40) underwent a yoga and diet intervention, the latter based on Asian Indian dietary guidelines. The 45-minute yoga sessions took place 6 days a week over 6 months. One-way analysis of variance was conducted to compare baseline, 3-month, and 6-month data. To determine the relationship between the variable and the QRISK3 score, a multivariate linear regression analysis was conducted in both the control and study groups. Following 6 months of the yoga and diet intervention, QRISK3 score decreased to 20.10 ± 7.05 from baseline values of 28.59 ± 10.15, a change that was statistically significant (p &lt; 0.0001) in the study group. The QRISK3 score was found to be a dependent risk factor for cardiovascular disease (p &lt; 0.001) in univariate linear regression analysis. For individuals who were at high risk for cardiovascular disease, significant independent risk factors were body mass index (β = −0.137, p = 0.034), systolic blood pressure (β = 0.208, p = 0.000), and total cholesterol/high-density lipoprotein (β = 2.59, p = 0.042). This study’s findings suggest that a 24-week yoga lifestyle intervention (including diet) significantly decreased the QRISK3 score among individuals at high risk for cardiovascular disease compared to the control group.
Retratos da prisão e da Favela em crônicas do fim do século XIX
Authors: Da Silva Fátima Almeida 
Published: December 2024

RESUMO:Neste artigo, investigaremos algumas crônicas do fim do século XIX dos seguintes autores: Benjamim Costallat, João do Rio e Orestes Barbosa. Nosso recorte será temático: as crônicas delineiam uma perspectiva dos cronistas sobre a prisão. Interessa-nos saber o modo como cada cronista narra tanto a prisão do fim do século, quanto a Favela – o nome de um morro do Rio de Janeiro. Vale dizer que, em Benjamim Costallat, a prisão é metafórica, tendo em vista que o cronista descreve os sanatórios do fim do século. Lemos o sanatório como uma forma de prisão. João do Rio, como repórter, descreve as prisões visitadas por ele. Para comparar o modo de abordagem da prisão, selecionamos, duas crônicas de Orestes Barbosa que, tendo sido preso, revela-nos um olhar singular dessa prisão. Como arcabouço teórico, lançaremos mão de Ben Singer que estuda a Modernidade. Além disso, contamos com textos críticos sobre o gênero crônica.
Renuncia Silenciosa: Propuesta de una red nomológica de antecedentes, consecuencias y terceras variables
Authors: Salessi Solana 
Published: December 2024

La pandemia por COVID-19 socavó muchos de los principios y paradigmas que regían el mundo del trabajo hasta el año 2020. En el nuevo escenario laboral dos fenómenos reclaman particularmente la atención de los y las investigadores/as del comportamiento organizacional. Por un lado, la ola de desvinculaciones masivas conocida como “gran renuncia”. Por otro lado, la actitud de escaso compromiso, mínimo esfuerzo y nula proactividad laboral que se comienza a imponer entre aquellos trabajadores/as que no pueden renunciar a sus empleos en el plano real. Este último fenómeno, recogido en la literatura como “renuncia silenciosa”, es el objeto de estudio del presente ensayo. Por tratarse de un fenómeno emergente, aún no se dispone de un corpus de conocimientos concluyente. Este artículo pretende ser una contribución teórica, proporcionando una red nomológica de la renuncia silenciosa. Vale decir, una representación de la interrelación entre este constructo y un selecto elenco de variables psicosociales postuladas como predictores, consecuencias o terceras variables, respectivamente. En este sentido, sobre los cimientos forjados por la teoría demandas y recursos laborales (DRL), el modelo de organizaciones saludables y resilientes (HERO), el modelo de aplicación-construcción de emociones positivas (ACE), los desarrollos en materia de mediación y moderación de variables, y la evidencia empírica preliminar en torno a la problemática bajo análisis, este escrito propone una serie de supuestos teóricos sobre sus antecedentes, consecuencias y variables mediadoras-moderadoras. El presente trabajo da el puntapié inicial para investigar esta temática en el contexto local, ofreciendo un modelo teórico para lograr una comprensión más profunda del constructo, e identificando una serie de áreas de vacancia a modo de agenda para la investigación futura.
Trudny teren w badaniu światów społecznych. Uwagi metodologiczne na podstawie badań nad strzelectwem sportowym
Authors: Zwarycz Piotr A. , Afeltowicz Łukasz 
Published: December 2024

Artykuł skupia się na wyzwaniach związanych z realizowaniem badań jakościowych w terenie „trudnym”, z wykorzystaniem teorii światów społecznych. Na przykładzie realizacji konkretnego projektu badawczego (badania świata społecznego polskich strzelców sportowych) autorzy omawiają możliwe wyzwania „trudnego terenu” oraz wybrane rozwiązania. Zwracają szczególną uwagę na problemy dotyczące badania tych światów społecznych, których uczestnicy mają syndrom oblężonej twierdzy, gdzie występują problemy trudnych emocji w badaniu tematów społecznie kontrowersyjnych, pojawiają się kwestie wysokiego progu wejścia związanego z wiedzą techniczną oraz ryzyko stubylczenia.
EFFICIENCY OF HEALTH EXPENDITURE IN ORGANIZATION OF ISLAMIC COOPERATION (OIC) COUNTRIES: A DATA ENVELOPMENT ANALYSIS APPROACH
Authors: Helwa Lina Af'ida Fataya , Rima Hadijah 
Published: December 2024

<p>Studies concerning the efficiency of health spending rank among the primary priorities in global policies aimed at enhancing health equity through improved health services and care. This study focuses on countries belonging to the Organization of Islamic Cooperation (OIC) due to their limited access to healthcare, government health spending, and increasing out-of-pocket expenditure. The study aims to measure efficiency scores of healthcare expenditure in OIC member countries. This research is a quantitative study using a Data Envelopment Analysis (DEA) approach. This study using two variables this input and output variables. Input variables are such as total health expenditures, government health expenditures, and out-of-pocket health expenditures per capita PPP current International $, while output variables include life expectancy and infant mortality per 1,000 births. All variables are secondary data derived from World Develompment Indicators (WDI) in World Bank. The research sample comprises 50 out of 57 OIC countries during 2004-2018. Results indicate that the average efficiency score of OIC countries from 2004 to 2018 was 0.551. Predominantly, countries in the Middle East demonstrated the highest efficiency scores, with Qatar leading followed by Brunei Darussalam, Kuwait, UAE, and Saudi Arabia, while Egypt recorded the lowest efficiency score. Based on this research, OIC countries are encouraged to diversify government-owned insurance policies, allocate government health expenditures more precisely, reduce the stunting rate among children, protect the health of pregnant women, and promote health investments.</p>
Transfemoral Osseointegration for Amputees with Well-Managed Diabetes Mellitus
Authors: Hoellwarth Jason S. , Al-Jawazneh Shakib , Oomatia Atiya , Tetsworth Kevin , Al Muderis Munjed 
Published: December 2024

Background:
The most common reason for lower-extremity amputations remains the management of complications of diabetes mellitus (DM) and/or peripheral vascular disease. Traditional socket prostheses remain the rehabilitation standard, although transcutaneous osseointegration for amputees (TOFA) is proving a viable alternative. Limited studies of TOFA for vascular amputees have been published, but no study has focused on TOFA for patients with DM, neglecting this important patient population. The primary aim of the present study exploring this potential care option was to report the frequencies and types of adverse events following TOFA for patients with well-controlled DM. The secondary aims were to report their mobility and quality-of-life changes.

Methods:
A retrospective review was performed of 17 consecutive patients with well-controlled DM who had undergone unilateral transfemoral TOFA from 2013 to 2019 and had been followed for at least 2 years. Outcomes were perioperative complications, additional surgery (soft-tissue refashioning, debridement, implant removal, periprosthetic fracture treatment), mobility (daily prosthesis wear hours, K-level, Timed Up and Go Test, 6-Minute Walk Test), and patient-reported outcomes (Questionnaire for Persons with a Transfemoral Amputation, Short Form-36).

Results:
There were no perioperative systemic complications, deaths, or proximal amputations. Two patients (12%) sustained a periprosthetic fracture following a fall, managed by internal fixation with implant retention, and regained independent ambulation. Eight patients (47%) had additional surgery or surgeries for non-traumatic complications: 4 (24%) had soft-tissue refashioning, 3 (18%) had debridement, and 3 others had implant removal with subsequent revision osseointegration for aseptic loosening (1) or infection (2). The proportion of patients wearing their prosthesis at least 8 hours daily improved from 5 (36%) to 11 (79%) of 14 (p = 0.054). The proportion of patients who achieved at least K-level 2 improved from 6% to 94% (p < 0.001). Other changes were not significant.

Conclusions:
Contraindicating TOFA for all patients with DM seems draconian. Patients with well-controlled DM experienced significant mobility improvements, although additional surgery was somewhat common. Improvements in selection criteria or surgical technique to reduce risks are needed so that TOFA can be routinely considered for amputees with well-controlled DM.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Influence of Combined Transcranial and Peripheral Electromagnetic Stimulation on the Autonomous Nerve System on Delayed Onset Muscle Soreness in Young Athletes. A Randomized Clinical Trial.
Authors: Keirven Hugo , Sierra Alberto Sánchez , González-de-la-Flor Ángel , Arrabé María García , Frutos Marta de la Plaza San , Maestro Arturo Ladriñán , -Garcia-Perez-de-Sevilla Guillermo , Aguilera José Francisco Tornero , Suarez Vicente Javier Clemente , Balmaseda Diego Domínguez 
Published: December 2024

Abstract

Background
Delayed Onset Muscle Soreness (DOMS) has been extensively studied by scientists and sports teams over the last few decades. Eccentric exercises impact physiology and recovery, as shown in recent studies. This study investigates the effects of combined transcranial and peripheral electromagnetic stimulation on the autonomic nervous system in 48 young athletes. Participants were divided into four groups: Control (n = 12), Peripheral (n = 13), Transcranial (n = 11), and Combined (n = 12). The autonomic nervous system was assessed through Heart Rate Variability (HRV) monitoring before and after the eccentric session that induced DOMS and at 24h, 48h, and 72h post-session.
Results
The Combined Group showed increased activation in various HRV parameters, including LF (p < 0.001), HF (p < 0.001), and the LF/HF power ratio (p < 0.001). These results indicate that combined transcranial and peripheral electromagnetic stimulation enhances recovery in athletes after 72 hours.
Conclusions
Paired-associative electromagnetic stimulation positively influences the autonomic nervous system response in young athletes, promoting recovery without disrupting the typical physiological recovery process in DOMS.
Early evaluation of anti-angiogenic effects with gadolinium (III) labeled APN/CD13 specific binding peptides magnetic resonance imaging
Authors: Han Sheng , Liu Song-Song , Jing Gong-Wei , Wang Pin-Qin , Zhang Yan-Teng , Xiong Ling , Zhang Ying-Fang , Qu Hua-Sheng , Ren Bing-Xiu 
Published: December 2024

Abstract

Background
Anti-angiogenesis has been recognized as a crucial strategy in anti-tumor therapy, and the early assessment of its efficacy is equally significant. In this study, we developed a magnetic resonance (MR) probe specifically targeting angiogenesis to facilitate targeted imaging for the early evaluation of anti-angiogenic effects.
Methods
We synthesized DOTA-G3CNGRC, conjugated it with gadolinium (III), and subsequently evaluated the labeled probe in vitro. Tumor-bearing mouse models of HT-29 (CD13-negative expression) and HT-1080 (CD13-positive expression) were established, followed by MR Imaging conducted via intraperitoneal injection of the labeled probe and Gd-DOTA at a dosage of 0.5 mg/kg/day before and after ubenimex treatment over a consecutive period of seven days. The average pixel ratio of the transplanted tumor (target tissue, T) to the left hind leg (non-target tissue, NT) was determined using the region of interest technique (ROI), while changes in tumor size were meticulously recorded. Additionally, APN/CD13 expression levels in transplanted tumors were assessed both prior to and following treatment.
Results
The labeling rate of probes was 88.99%. The IC50 of the probes was 61.66 nM. The T/NT ratio of HT-1080 was significantly higher than that of HT-29 (P < 0.001, n = 5). After treatment, the T/NT value of HT-1080 transplanted tumors was significantly decreased (P < 0.001, n = 5), accompanied by a significant decrease in CD13 expression and unapparent changes in tumor size ( P = 0.710, n = 5).
Conclusion
The Gd-DOTA-G3CNGRC probes appeared potential for targeted MR imaging in assessing the early efficacy of anti-APN/CD13 drugs.
RMC-7977 a broad RAS inhibitor increases the sensitivity towards Bortezomib
Authors: Singha Didhiti , Mondal Meghna , Malakar Pushkar 
Published: December 2024

Abstract

The drug Bortezomib commonly treats patients with multiple myeloma. However, its use is more limited in other cancers, such as hepatocellular and cervical cancer. Additionally, reports have indicated cases of resistance to Bortezomib. In this context, studies have demonstrated that Ras signaling plays a significant role in influencing the sensitivity of cancer cells to chemotherapeutic drugs. A new experimental drug called RMC-7977 was made by Revolution Medicines. It targets the active, GTP-bound forms of RAS proteins, such as KRAS, NRAS, and HRAS. Since RMC-7977 is a broad Ras inhibitor recently discovered, we sought to evaluate its efficacy in enhancing the sensitivity of cancer cells to Bortezomib. Our study aimed to assess the effect of RMC-7977 on Bortezomib sensitivity. The results show that HeLa and HepG2 cells exhibit lower sensitivity to Bortezomib compared to RPMI-8266 cells. However, combination therapy with RMC-7977 and Bortezomib increases the sensitivity of HeLa and HepG2 cells to Bortezomib. Cycloheximide has a big effect on the levels of Ras protein in RPMI-8266 cells, but it doesn't change them at all in HeLa and HepG2 cells. These findings underscore the crucial role of Ras signaling in determining sensitivity to Bortezomib. The present study also highlights the potential of the RMC-7977 inhibitor in enhancing the response to Bortezomib. This work could broaden the scope of FDA-approved Bortezomib to include additional cancers beyond multiple myeloma and improve outcomes for patients with chemoresistant multiple myeloma. Furthermore, it may open up new therapeutic applications for the recently discovered RMC-7977.
Dermatologic diseases in Africa: The profile of patients attending a tertiary hospital in the Ashanti Region of Ghana
Authors: Agyei Martin Kofi , Sakyi Samuel Asamoah , Annan John Jude , Norman Betty Roberta , Enimil Anthony Kwame , Senu Ebenezer , Opoku Stephen , Kokuro Collins , Tannor Elliot , Ofori Afua , Effah Alfred , Amoani Benjamin 
Published: December 2024

Abstract

Background
Dermatological diseases are a substantial cause of discomfort, with debilitating effects on the affected person's confidence. However, there is a paucity of data on the prevalence of dermatological diseases and their associated factors in Ghana. We assessed the distribution of dermatological cases, its predictive factors, and common treatment options.
Methods
This observational study included 460 dermatological cases from dermatology unit of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana over 5 years, from January 2016 to December 2020. A data collection sheet was used to extract sociodemographic data, dermatology diseases and drugs for their management. Statistical analyses were done using SPSS Version 26.0 and GraphPad prism version 8.0. P < 0.05 was considered statistically significant.
Results
The highest proportion of dermatological cases were chronic eczema (14.8%), acne vulgaris (10.2%), atopic eczema (8.3%), folliculitis (6.7%), vitiligo (6.5%) and pityriasis rosea (5.2%). A significant number were also prurigo (3.9%), urticaria (3.7%), epidemic Kaposi sarcoma (3.7%) and infantile seborrhoeic dermatitis (3.0%). The proportion of idiopathic pruritus, alopecia areata, and lichen planus were 2.8%, 2.4% and 2.0% respectively. The proportion of systemic lupus erythematosus (1.7%) and haemangioma (1.7%) were significantly higher among females than compared to males (p = 0.049). Most participants were on cetirizine (43.2%), non-alkali soap (13.5%), ketoconazole cream (12.3%), folic acid/vitamin B12 (9.9%), multivitamin (7.1%), and clindamycin/erythromycin (7.1%).
Conclusion
The common dermatological diseases were chronic eczema, acne vulgaris, atopic eczema, folliculitis, vitiligo and pityriasis rosea. Some dermatological conditions are commoner among females and adulthood. Further future studies are recommended to augment other risk factors predilection to skin diseases in Ghana.
Sex-dependent association of serum alkaline phosphatase with grip strength in adults aged 20-59: NHANES 2013-2014
Authors: Zhang Ziyi , Zhou Jiajie , Ma Anpei , Chen Honggu , Wang Bo , Zhao Guoyang 
Published: December 2024

Abstract

Background
Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum alkaline phosphatase (ALP) is closely associated with muscle mass. Nevertheless, the association between serum alkaline phosphatase (ALP) and grip strength remains unclear. This study is designed to investigate whether there exists a connection between serum ALP levels and grip strength among individuals aged 20 to 59 years.
Methods
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013–2014, a cross-sectional survey design was employed to examine 2,182 adults (54.54% male and 45.46% female) aged between 20 and 59 years. Weight-corrected grip strength served as the dependent variable, while serum alkaline phosphatase (ALP) was identified as the primary variable of interest. The relationships were analyzed using generalized linear models, smooth curve fitting, generalized additive models, and stratified analyses.
Results
We discovered that alkaline phosphatase (ALP) was negatively linked with weight-corrected grip strength. When stratified by gender, age group and race, for all groups except for other races, serum alkaline phosphatase (ALP) were negatively correlated with weight-corrected grip strength. When divided into four groups according to gender and age, serum alkaline phosphatase (ALP) and weight-corrected grip strength showed an N-shaped relationship among male participants aged 20–39 years, and an L-shaped relationship among male participants aged 40–59 years, and among female shows a significant negative correlation regardless of age group.
Conclusions
Our research identified notable gender differences in the association between alkaline phosphatase (ALP) levels and weight-corrected grip strength among participants aged 20 to 59 years. This finding offers new insights and avenues for understanding how serum alkaline phosphatase affects skeletal muscle health.