bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic Study of Varicella Zoster Virus in Cerebrospinal Fluid ofStroke Patients in Thi-Qar Province
Authors: Fahail Zeena , Bushra Jabbar Hamad  
Published: December 2024

Varicella Zoster Virus (VZV), also known as alpha herpesvirus Virus 3, belongs to the Alpha Herpesviridae family and is a unique virus that can reactivate neurons and root ganglia in the nervous system and causes many neurological diseases, especially stroke. Molecular and genetic studies of viruses are valuable tools for virus development and identifying viral treatments to combat the disease. The study aims to demonstrate the causal roles of Varicella-zoster virus in the progression of stroke by detecting the presence of virus DNA in the patients CSF by real-time PCR technique. The study aimed to identify the relationship between VZV infection and demographic characteristics.
The current study involved 120 participants collected in Al-Husein Teaching Hospital, of which 90 patients with systemic manifestations of the central nervous system (CNS) with/without rash and 30 participants as a control group, the age of population ranging from 1 to70 years among them 73 males and 47 females VZV DNA was detected using Quantitative real-time PCR (ORF4) from CSF.
The results recorded 47 (39.17%) of both patients and control groups were positive for VZV, among them 34 (37.78%) in patients group and 13 (43.33%) cases in the control group. According to sex of patients, the females have the highest infection percentage. Also, noted that 52.78% of infection in the female group and 47.22% in the male group, regarding age groups, the sixth age group it was scored the high percentage of infection 66.67%, while the first age group scored a low infection percentage .
GAYA KOMUNIKASI PIMPINAN PADA MANAJER OPERASIONAL DI PT. TIGA SEKAWAN LOGISTIK
Authors: Riadri Ovian Senanda , Sarjono Herning Suryo , Itasari Andri Astuti 
Published: December 2024

Dalam sebuah perusahaan, komunikasi adalah suatu hal yang tidak dapat dipisahkan, karena dengan adanya komunikasi seseorang bisa menyampaikan dan juga menerima informasi. Selain itu untuk menyelesaikan berbagai persoalan dalam suatu perusahaan diperlukan gaya komunikasi yang tepat agar perusahaan tetap berjalan sesuai dengan rencana untuk mencapai tujuan tertentu. Adanya penelitian ini memiliki tujuan untuk mengetahui dan mendeskripsikan bagaimana gaya komunikasi Pimpinan pada manajer operasional di PT. Tiga Sekawan Logistik. Jenis dan motode penelitian yang digunakan adalah deskriptif kualitatif, menggunakan data premier dari hasil wawancara dan data sekunder dari dokumen, buku, dan jurnal. Teknik pengambilan data yang digunakan yaitu purposive sampling, sedangkan untuk menguji kredibilitas menggunakan Triangulasi teknik dan di analisa dengan metode analisis oleh Matthew, Huberman, dan Saldana (2014) yaitu Data Condensation, Data Display, dan Conclusion Drawing/Verifications. Dari hasil wawacara, observasi, dan pengumpulan data, peneliti menyimpulkan bahwa dari enam gaya komunikasi yang dikemukakan oleh Steward L Tubbs & Slyvia Moss terdapat dua gaya komunikasi pimpinan yaitu The Equalitarian Style Dan The Structuring Style yang digunakan oleh pimpinan manajer operasional di PT. Tiga Sekawan Logistik dalam memimpin bagian operasional. Gaya komunikasi Equalitarian yang terlihat dari sikap pimpinan yang santai, akrab dan mau menerima kritik saran, sehingga membuat karyawan mampu terbuka dan dapat mengeluarkan keluh kesah yang mereka rasakan. gaya komunikasi Structuring terlihat manakala pimpinan menekankan pada aturan kerja yang berlaku terutama berkaitan dengan jadwal kerja, kecepatan, dan kedisiplinan sehingga berpengaruh pada kualitas perusahaa
MENUMBUHKAN MOTIVASI BERPRESTASI PADA ANGGOTA KARANG TARUNA DESA SAMBIREMBE, KECAMATAN KALIJAMBE, KABUPATEN SRAGEN
Authors: Suranto Joko , Pramono Joko , Nugraheni Jacika Pifi 
Published: December 2024

Tujuan organisasi pemuda seperti Karang Taruna adalah untuk memberikan wadah bagi aspirasi masyarakat, khususnya generasi muda, dan untuk menumbuhkan rasa tanggung jawab sosial dan kepedulian terhadap masyarakat secara keseluruhan. Tujuan akhirnya adalah untuk meningkatkan kesejahteraan sosial bagi generasi muda.
Karang Taruna adalah organisasi sosial yang berfungsi sebagai wadah dan sarana pertumbuhan bagi setiap anggota masyarakat. Organisasi ini didirikan atas kesadaran dan tanggung jawab sosial oleh dan untuk masyarakat, terutama generasi muda di desa atau kelurahan, terutama mereka yang bekerja dalam bidang kesejahteraan. Karang Taruna berfungsi sebagai wadah pembinaan generasi muda dan tempat berbagai usaha atau kegiatan dilakukan untuk meningkatkan dan memupuk daya cipta, daya rasa, inisiatif, dan karya generasi muda dalam rangka pengembangan sumber daya manusia (SDM).
Desa Sambirembe, Kecamatan Kalijambe, Kabupaten Sragen memiliki organisasi kepemudaan yang disebut Karang Taruna, namun peran dari para anggota Karang Taruna di Desa ini belum menunjukan mativasi yang tinggi dalam melaksanakan peran dan fungsinya, sehingga diperlukan diperlukan upaya-upaya-upaya dalam menumbuhkan motivasi berprestasi pada para anggota Karang Taruna Desa Samirembe, Kecamatan Kalijambe, Kabupaten Sragen , dengan cara sebagai Eka Bina yaitu : bina manusia, Selain aspek tersebut perlu juga ditambahlan pentingnya bina kelembagaan, karena Bina manusia itu hanya akan terwujud seperti yang diharapkan, bila ditunjang dengan efektivitas kelembagaan yang telah ada.
Kata kunci : motivasi, berprestasi.
Exploring The Understanding of Philanthropy Among The Public in Oman
Authors: Mustapha Junita , Jaafar Juliana Rosmidah 
Published: December 2024

Major natural disasters and catastrophes often prompt the public and organizations to start rallying for donations and philanthropic efforts. However, there is a limitation in understanding the term philanthropy. This study explores the understanding of the definition of philanthropy by the general public in Muscat, Oman. This is a qualitative study using in-depth interviews. Informants were introduced through the snowball technique. Data for the study were collected by conducting 20 open-structured interviews via Google Meet and Zoom platforms with the informants. The study of philanthropy from the general public’s perspective in Oman is explored, suggesting the term philanthropy consisted of five domains which are the practice of good deeds, positive affective, rehabilitation, learned model, and gratitude. These terms are more commonly used over philanthropic behavior and appear more comprehensive of the multitude of connotations and deﬁnitions across cultures. Future studies could consider exploring more younger millennials from a wider area about their philanthropic understanding.
An assessment of the performance of the political parties in Afghanistan
Authors: Juma Hamdard Ali , Sousa Braga Maria do Socorro 
Published: December 2024

A formação de partidos políticos no Afeganistão tem sido baseada na estrutura étnica e tribal tradicional. A influência dos partidos na institucionalização e consolidação da democracia tem sido um tanto fraca. De fato, ao nos referirmos à história do Afeganistão, descobrimos que este país tem sido marcado por tensões e conflitos étnicos e religiosos. Esta pesquisa objetiva avaliar a trajetória histórica e o desempenho contemporâneo dos partidos políticos no Afeganistão. Especificamente, busca-se analisar a evolução da formação de partidos políticos desde 1947, categorizando-a em quatro regimes distintos: o regime dos reis, o regime comunista, os partidos jahadis e o regime democrático. O estudo se esforça para entender a dinâmica da proliferação de partidos políticos durante o regime democrático. A pesquisa empregou uma técnica de amostragem intencional para selecionar os participantes, consistindo de 21 membros de vários partidos políticos, 12 professores universitários com experiência em ciência política e 6 especialistas políticos afiliados a empresas de mídia. Um questionário foi aplicado entre esses participantes de três categorias distintas para reunir insights abrangentes sobre o contexto histórico e o cenário contemporâneo dos partidos políticos no Afeganistão. Por meio de análises qualitativas e quantitativas, o estudo visa discernir padrões, tendências e o desempenho geral dos partidos políticos no país.
Palavras-chave: Afeganistão. Avaliação. Partidos políticos. Desempenho. Governo.
Confucionismo, tradição e feminismo
Authors: De Morais Silva Amanda , Benvenuto Lima Junior Jayme 
Published: December 2024

O presente artigo busca explorar e refletir a respeito da influência da tradição político-filosófica do Confucionismo nas relações entre homens e mulheres e na construção de valores de igualdade de gênero na Coreia do Sul. Além disso, busca traçar as compatibilidades dessa filosofia com as demandas feministas por igualdade. Em primeiro lugar, fala-se das origens do Confucionismo no início do Estado coreano, com foco nos princípios que institui a respeito da posição de mulheres - sua liberdade e identidade - diante do Estado, que adota tal filosofia como guia fundante de suas estruturas e relações. Em segundo lugar, traz-se as discussões da modernidade e contemporaneidade a respeito da possibilidade de compatibilidade entre os preceitos político-filosóficos do Confucionismo e a atual mobilização do movimento feminista contra a estrutura patriarcal formada ao longo da história coreana.
Palavras-chave: Feminismo. Confucionismo. Tradição. Coreia do Sul. Igualdade de gênero
Penerapan Honeypot Sebagai Sistem Keamanan Server Berbasis Linux
Authors: Maharani Feni , Kalsum Toibah Umi , Alamsyah Hendri 
Published: December 2024

The application of honeypot as a linux-based server security system can help secure servers, can help detect attacks that occur on computer networks, and display the results of attacks that occur in logs stored on cowrie honeypots. With the existence of a honeypot, it can be used as a distraction from the attacker and is able to take information about the attack that occurred and the information of the attacker. Honeypot is implemented into a system that becomes a dummy system with the aim of attracting attention, detecting, and examining attacks that occur and are carried out by attackers. Based on the tests that have been carried out, it can be concluded that the application of honeypot in the linux-based server security system at SMK Negeri 3 Bengkulu is able to manipulate ports such as ports 22 and 23, so that it can avoid and secure ports from attacks such as ping of death which was tested using the LOIC, SSH, Telnet applications, port scanners which were tested using the advanced port scanner application, which is stored in the Cowrie Honeypot logs.
Computational modeling of superparamagnetic nanoparticle-based (affinity) diagnostics
Authors: Van Dieren Loïc , Tereshenko Vlad , Oubari Haïzam , Berkane Yanis , Cornacchini Jonathan , Thiessen EF Filip , Cetrulo Curtis L. , Uygun Korkut , Lellouch Alexandre G. 
Published: December 2024

IntroductionMagnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), are renowned for their superparamagnetic behavior, allowing precise control under external magnetic fields. This characteristic makes them ideal for biomedical applications, including diagnostics and drug delivery. Superparamagnetic IONPs, which exhibit magnetization only in the presence of an external field, can be functionalized with ligands for targeted affinity diagnostics. This study presents a computational model to explore the induced voltage in a search coil when MNPs pass through a simulated blood vessel, aiming to improve non-invasive diagnostic methods for disease detection and monitoring.MethodsA finite element model was constructed using COMSOL Multiphysics to simulate the behavior of IONPs within a dynamic blood vessel environment. Governing equations such as Ampère’s law and Faraday’s law of induction were incorporated to simulate the induced voltage in a copper coil as MNPs of various sizes flowed through the vessel. Rheological parameters, including blood viscosity and flow rates, were factored into the model using a non-Newtonian fluid approach.ResultsThe amount of MNPs required for detection varies significantly based on the sensitivity of the detection equipment and the size of the nanoparticles themselves. For highly sensitive devices like a SQUID voltmeter, with a coil sensitivity approximately 10−12 V, very low MNP concentrations—approximately 10−4 μg/mL—are sufficient for detection, staying well within the safe range. As coil sensitivity decreases, such as with standard voltmeters at 10−8 V or 10−6 V, the MNP concentration required for detection rises, approaching or even exceeding potentially toxic levels. Additionally, the physical size of MNPs plays a role; larger nanoparticles (e.g., 50 nm radius) require fewer total particles for detection at the same sensitivity than smaller particles like those with a 2.5 nm radius. For instance, at a coil sensitivity of 10−10 V, a 2.5 nm particle requires approximately 1012 particles, whereas a 50-nm particle only needs 108. This highlights the importance of optimizing both detection sensitivity and particle size to balance effective detection with safety.ConclusionThis computational model demonstrates the feasibility of using superparamagnetic nanoparticles in real-time, non-invasive diagnostic systems.
Analysis of clinical and biochemical characteristics and left ventricular hypertrophy in patients with indeterminate saline infusion test results
Authors: Qu Huiyun , Zhao Jingge , Wang Lulu , Du Huiyu , Zhang Qinghui , Sun Tingxi , Zhang Chen , Chen Jiaxuan , Guo Linya , Huang Qi , Tian Dandan , Liu Zhilan , Hao Yibin , Liu Min 
Published: December 2024

IntroductionThe clinical biochemical characteristics and target organ damage (TOD) in patients with plasma aldosterone concentrations (PAC) ranging from 50 to 100 ng/L after a saline infusion test (SIT) have not been fully studied.MethodsA total of 611 hypertensive patients with an elevated aldosterone-to-renin ratio (ARR) who underwent a supine SIT at Henan Provincial People’s Hospital were enrolled. The patients were divided into three groups according to their post-SIT PAC: &lt;50 ng/L (control group), 50–100 ng/L (indeterminate post-SIT results group), and &gt;100 ng/L (PA group). The clinical and biochemical characteristics and TOD of the three groups were compared. The correlation of the post-SIT PAC with left ventricular mass index (LVMI) was assessed via regression analysis.ResultsThe indeterminate post-SIT results group had the youngest patients and the shortest duration of hypertension. The prevalence of renal impairment (RI) and left ventricular hypertrophy (LVH) was lower than that in the PA group (P&lt;0.05), but there was no statistically significant difference from the control group (P&gt;0.05). After adjustment for confounders, the risk of developing carotid plaque was greater in the indeterminate post-SIT results group than in the control group (OR 1.73, 95% CI: 1.11, 2.69), and the prevalence of RI and LVH tended to increase with increasing post-SIT PAC levels. In multiple regression analyses, LVMI was significantly correlated with post-SIT PAC (P&lt;0.05), but the basal PAC, plasma renin activity, and ARR did not significantly correlate with LVMI (P&gt;0.05).ConclusionA post-SIT PAC of 50–100 ng/L may be indicative of an early form of PA, and it may serve as an independent predictor of LVH, which could be related to the level of autonomously secreted aldosterone.
Evaluating levee setback distance for the co-benefits of groundwater recharge and riparian ecosystem function
Authors: Calderwood Andrew J. , Rodriguez Alisha , Foglia Laura , Dahlke Helen E. 
Published: December 2024

Constructed levees are designed to protect anthropogenic developments from destructive flooding events, but their construction has reduced groundwater recharge, increased flood risk severity under levee failure, increased the incision of river channels, and deteriorated riparian habitat. To reverse these impacts, levee setbacks are often designed to reduce flood risk and provide the opportunity to restore ecohydrological function, while groundwater recharge is rarely considered because it may require relatively detailed groundwater system analysis. In this study, we evaluated 100 heterogeneous hydrogeology realizations to estimate recharge with high-conductivity pathways (HCPs) under varying flood flows for a range of levee setback distances to identify the trade-offs in groundwater recharge and floodplain habitat. We find that on a regional scale, total recharge potential increases with setback distance, with the largest gains up to 1,400 m where there are outcropping HCPs and sufficient flow to inundate more of the setback area. In contrast, the recharge per unit area (i.e., the average daily recharge divided by setback area) generally decreases as levee setback increases, but there are local increases in the recharge per unit area at 1,400 m where HCP recharge may sufficiently offset the larger area. There is a median 10%–40% reduction in peak streamflow with increasing setback distance, which would aid flood risk reduction, but the increased area leads to decreasing depth due to flow losses and increased spreading of flood water. Ultimately, the decision for levee setback distance will depend on local conditions and management goals, as we find that increasing recharge will reduce the floodplain depth necessary for ecosystem function. Our results highlight the opportunity to consider groundwater recharge benefits in levee setback feasibility studies in semi-arid regions impacted by floods and groundwater overdrafts so that setback distance designs can achieve integration of flood risk reduction, riparian habitat, and groundwater recharge.
Speckle tracking ultrasound as a new tool to predict the weaning outcome of mechanical ventilation patients: a prospective observational study
Authors: Li Rui , Zhou Yao , Chen Wan , Lyu Liwen , Qiu Guozheng , Pan Chunxi , Tang Yutao 
Published: December 2024

IntroductionSpeckle tracking ultrasound is a novel technique for evaluating diaphragm movement, yet its guidance in weaning mechanically ventilated patients remains unclear. In this study, we assessed diaphragmatic function using speckle tracking ultrasound and guided the weaning process.MethodsA total of 86 mechanically ventilated patients were included and divided into successful or failed weaning groups. Diaphragmatic function was assessed using speckle tracking ultrasound, M-ultrasound diaphragm excursion (DE), and diaphragmatic twitch force (DTF) after 30 min spontaneous breathing trial (SBT). The diagnostic performance of these indicator in predicting weaning outcomes was also evaluated.ResultsIn this study, a total of 86 patients completed the follow-up for weaning outcomes, with 35 cases of weaning failure and 51 cases of successful weaning. Logistic regression analysis identified whole strain (p = 0.037) and DE (p = 0.004) as independent predictors of weaning outcome. Receiver operating characteristic (ROC) curve showed that the strain threshold for Costal Diaphragm (Dlcos) was −9.836, Area Under the Curve (AUC) value was 0.760, the predictive specificity for weaning failure was 72.5%, and the sensitivity was 80%. DE value exceeding 1.015 cm had an AUC value of 0.785, noting that DE value had a high specificity (90.2%) for predicting successful weaning, but a lower sensitivity (60%). After merging, the AUC of whole strain and DE was 0.856, and the sensitivity (80%) and specificity (80.4%) were more balanced compared to using DE alone.ConclusionThe findings of this study demonstrate the feasibility of using speckle tracking ultrasound to assess diaphragmatic function in mechanically ventilated patients. The combined utilization of whole strain and DE provides a more precise evaluation of diaphragmatic function in ICU patient, which may improve patient outcome.
Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11
Authors: Mlakar Vid , Oehme Ina , Lesne Laurence , Najafi Sara , Ansari Marc , Gumy-Pause Fabienne 
Published: December 2024

BackgroundWe previously demonstrated that APR-246 (eprenetapopt) could be an efficient treatment option against neuroblastoma (NB), the most common pediatric extracranial solid tumor. APR-246’s mechanism of action is not completely understood and can differ between cell types. Here we investigate the involvement of well-known oncogenic pathways in NB’s response to APR-246.MethodsA proteome profiler kinase assays and western blot analysis were used to identify the molecular pathways involved in the responses to APR-246. Bulk ATP levels were used to determine the viability of cells and the IC50 for APR-246. Cystine-FITC was used to measure the cellular uptake of cysteine. PmRNA5 was used to activate ERK1/2 and pshRNA1 was used to silence HSP27. An IMR-32 xenograft zebrafish embryo model was used to assess APR-246 and sulfasalazine efficacy in vivo.ResultsAfter APR-246 treatment, the most deregulated signaling protein identified was ERK1/2, an end-point kinase of the RAS-MAPK pathway. Induction of phospho-ERK1/2 resulted in increased glutathione (GSH) levels, increased cystine uptake, and increased resistance of NB cells to APR-246. Using ERK1/2 inhibitors in combination with APR-246, we were able to categorize cells into synergistic and antagonistic groups. After co-treatment, these two groups differ by their levels of SLC7A11 and Hsp27 phosphorylation, cystine uptake, and BIM expression. Using erastin and sulfasalazine, both inhibitors of SLC7A11 and activators of ferroptosis, we were able to reverse the antagonistic effects of ERK1/2 inhibitors and demonstrate a strong synergistic action in vitro and in vivo in zebrafish models.ConclusionsThese results demonstrated a pivotal role of the RAS-MAPK pathway in the NB cellular response to APR-246 via the modulation of intracellular concentrations of GSH and the transport of cystine through SLC7A11, phosphorylation of Hsp27, and programmed cell death. Combining APR-246 with RAS-MAPK pathway inhibitors can, in some cases, lead to antagonistic action, which can be reversed by combining APR-246 with the clinically approved drug sulfasalazine.