bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annotated bibliography of the Russian literature on glaciology for 2014
Authors: Kotlyakov V. M. , Chernova L. P. 
Published: March 2019

The proposed annual bibliography continues annotated lists of the Russian-language literature on glaciology that were regularly published in the past. It includes 271 references grouped into the following ten sections: 1) general issues of glaciology; 2) physics and chemistry of ice; 3) atmospheric ice; 4) snow cover; 5) avalanches and glacial mudflows; 6) sea ice; 7) river and lake ice; 8) icings and ground ice; 9) the glaciers and ice caps; 10) palaeoglaciology. In addition to the works of the current year, some works of earlier years are added, that, for various reasons, were not included in previous bibliographies.
Orális antikoagulánssal már kezelt pitvarfibrilláló betegek egyéves terápiahűsége
Authors: Simonyi Gábor , Ferenci Tamás , Finta Ervin , Gasparics Roland , Medvegy Mihály 
Published: March 2019

Abstract: Introduction: In the treatment of non-valvular atrial fibrillation (AF) with oral anticoagulants (OAC), medical adherence is a relevant factor for stroke prevention. Aim: To evaluate the one-year persistence of vitamin K antagonists (VKA) and direct oral anticoagulants (DOAC) in patients suffering from AF and already treated with OACs. Method: Information from the National Health Insurance Fund of Hungary prescriptions database on pharmacy claims between June 1, 2015 and December 31, 2015 was analysed. Authors identified patients who filled prescriptions for OACs (VKAs or DOACs) prescribed for AF who have already received OACs therapy during one year before. Apparatus of survival analysis was used, where ‘survival’ was the time to abandon the medication. Results: 196 016 patients met the inclusion criteria. 181 810 patients received VKA and 14 206 patients were treated with DOACs. The one-year persistence rate in patients taking VKA was 52.9% whereas it was 66.8% in those on the DOACs. The persistence rates after 360 days were 67.5% for rivaroxaban, 63.6% for apixaban and 63.4% for dabigatran. The mean duration of persistence was 311 days for rivaroxaban, 308 days for apixaban and 284 days for dabigatran. The actual rate of discontinuation was 14% (HR = 1.14 [95% CI 1.05–1.24]), p = 0.0015) for apixaban, 15% (HR = 1.15 [95% CI 1.08–1.23], p = 0.003) for dabigatran and 62% (HR = 1.62 [95% CI 1.56–1.69], p<0.0001) for VKA compared to rivaroxaban (reference). Conclusions: The authors have confirmed that the one-year persistence of DOAKs was significantly higher compared to KVA therapy in AF. The one-year persistence of rivaroxaban was more favoured than apixaban and dabigatran. Orv Hetil. 2019; 160(13): 509–515.
A minimális residualis betegség vizsgálatának jelentősége myeloma multiplex kezelése után
Authors: Szendrei Tamás , Plander Márk , Szabó Zsuzsanna , Kereskai László , Kajtár Béla , Papp Gergely , Iványi János László 
Published: March 2019

Abstract: Introduction: Prognostic impact of the detection of minimal residual disease (MRD) in multiple myeloma (MM) has been confirmed in numerous studies. Aim: Retrospective examination of our patient database (107 newly diagnosed multiple myelomas between 2007 and 2017). Flow cytometry (FCM) was performed as MRD assessment. Method: MRD assessment was performed in 56 patients (median age: 68 years), after induction treatment of multiple myeloma. The treatment contained bortezomib in 91%, autologous haematopoetic stem cell transplantation (ASCT) was perfomed in 50%. MRD detection was performed on bone marrow samples, predominantly in our hospital (BD FACScan, 3 colour, panel: CD38, CD138, CD19, CD45, CD56, CD28, CD117, cyKappa, cyLambda, 100 000 events). Statistical analysis: SPSS 13.0. Results: The progression-free survival (PFS) and the overall survival (OS) were significantly longer in MRD negative (n = 22) patients (PFS: 54 months, OS: 79% after 5 years) than MRD positive patients (n = 34, PFS: 22 months, OS 21% after 5 years, p = 0.001). Patients achieving complete response (CR) (n = 29) have different PFS (MRD negative CR: 60 months, MRD positive CR: 21 months, p<0.001). Patents achiving MRD negative very good partial response (n = 5) have similar PFS (54 months) as patients with MRD negative CR. The longest PFS (68 months) was observed in MRD negative patients, after ASCT (n = 11), while the PFS was significantly (p<0.001) shorter in patients who were MRD positive after ASCT (n = 18, PFS: 25 months), similarly in MRD positive patients without ASCT (n = 15, PFS 21 months). Cox regression analysis (stage, cytogenetic risk, ASCT) confirmed that MRD is an independent prognostic factor of PFS and OS. We did not find significant relationship between MRD and stage, cytogenetic risk, number of treatment cycles, ASCT. Conclusions: The depth of response after induction treatment of MM is an independent predictor of survival. MRD assessment with FCM is recommended to define response. Consideration of maintenance treatment in MRD positive patients and eradication of MRD are also recommended. Orv Hetil. 2019; 160(13): 502–508.
A szexuális nevelésről orvosi szemmel a hazai adatok és a nemzetközi irányelvek tükrében
Authors: Varga-Tóth Andrea , Németh Gábor , Paulik Edit 
Published: March 2019

Abstract: Introduction: The prevention of early sexual life and its unwanted consequences is a worldwide problem. National and international surveys have shown that adolescents have their first sexual intercourse at a younger age. Aim: The study aimed to determine the way of sexual education of young people provided by physicians – general practitioners, paediatricians, obstetricians, gynaecologists etc. – in accordance with the results of a questionnaire-based study, the experiences gained during the interactive education and the suggestions of international guidelines dealing with sexual education. Method: Self-administered questionnaire-based study was performed among 13–18-year-old girls attending primary or secondary school (N = 868) between 2009 and 2016. The sexual activity of adolescent girls, their knowledge related to contraception and sexually transmitted infectious diseases, gynaecological (e.g., cancer screening) experiences were measured before sexual education performed by a gynaecologist. Results: Every 4th girl had the first sexual act at the age of 14 or before, but at the same time their sexual knowledge was incomplete and there was a significant proportion of those who already have had sex but have never had a gynaecological examination. Conclusion: The results highlighted the educational deficiencies of reproductive life, which is a complex task to solve, to address the changing approach of national healthcare and education systems, to adopt and follow scientific evidence-based guidelines. All health-care workers who are in contact with adolescents during their work must be involved in the sexual education. It is essential to continue incorporating sex education into education from early childhood to young adult age. Orv Hetil. 2019; 160(13): 494–501.
Tales from the Trenches: Conducting Yoga Research on Low Back Pain
Authors: Sherman Karen , Rothenberg Robin 
Published: March 2019

Clinical studies of Yoga for various medical conditions funded by the National Center for Complementary and Alternative Medicine (NCCAM), a part of the National Institutes of Health (NIH), have been conducted for the past several years. These are important studies for the understanding and acceptance of Yoga therapy by the biomedical community and health care financing institutions. They also raise many fundamental and fascinating questions about how science studies Yoga.
The results of major academic studies on Yoga are generally first reported in mainstream medical journals. The International Journal of Yoga Therapy, however, attempts to carry complementary articles describing in much more detail the methodology and other aspects of the studies of special interest to our readers. In the present case, an unusual opportunity arose to explore methodological issues in depth, including the collaboration between the researcher and the Yoga teacher. Karen Sherman, Ph.D., M.P.H., the principal investigator, has extensive experience in studying complementary and alternative medicine (CAM) therapies for back care and is quite conversant with the methodological challenges of Yoga and other CAM research from a variety of perspectives. She also is a longtime Raja-Yoga practitioner. Robin Rothenberg, the Yoga teacher employed for the study, is an experienced Yoga teacher and therapist certified in both the Viniyoga and Iyengar methodologies and a member of IAYT's Advisory Council. Readers may recognize her from her article in the 2004 issue of the journal, "Therapeutic Yoga 101: A Course in Self- Acceptance."
The brief description of the low back pain study that appears on the NCCAM website (www.clinicaltrials. gov/ show/NCT00056212) follows:
Back problems are among the most prevalent conditions affecting adults and are a leading reason for using complementary or alternative medical (CAM) therapies. Despite the common use of CAM therapies for back pain, little is known about how they compare with conventional treatments. This study will lay the groundwork for a full-scale trial that compares yoga with conventional exercise and usual care for chronic low back pain.
This study will randomize 30 people with chronic low back pain to each of the following groups: yoga, a conventional therapeutic exercise program, and usual care. There will be 12 weeks of weekly treatment and follow-up assessments via phone at 6, 12, and 26 weeks to measure each treatment's impact on symptoms, function, quality of life, and utilization and costs of back pain related care.
IAYT is most pleased to have this opportunity to explore the story behind the study. We hope this discussion helps our members better understand the science as well as the great amount of work and creativity a study such as this entails. We also hope this discussion helps Yoga therapists and medical researchers better understand each other and encourages further collaboration.
Usefulness of High Resolution Computed Tomography scans in depicting the status of the middle ear structures
Authors: Kumar Ponnam Bharath , Mai Kiran , Karpur Santosh 
Published: March 2019

Background: Prior to surgery it is very important that the surgeon is fully aware, and he should have the clear picture as to the extent of the disease and the nature of the disease to give satisfactory surgical outcomes for the patient. HRCT (High resolution computed tomography) is one such guiding tool for the surgeon. The objective was to study usefulness of HRCT scan in attico-antral disease in depicting the status of the middle ear structures.Methods: A total of 30 patients were studied. HRCT temporal bone was performed by using SIEMENS EMOTION 16 slice CT machine in axial plane and coronal images were reformatted. Findings of HRCT temporal bone were recorded. Findings of mastoid exploration surgery were recorded. Report of HRCT of temporal bone was correlated with surgical findings and tabulated using percentages.Results: Surgery showed cholesteatoma in 26 (86.6%) patients. Epitympanum was involved in 29 (96.6%) patients in HRCT and 30 (100%) patients at surgery. Extension beyond middle ear cleft was seen in 4 (13.3%) patients in HRCT and 5 (16.6%) patients at surgery. Tympanic segment of facial canal was the most commonly involved, showing erosion in 10 (33.3%) patients in HRCT and 12 (40%) patients at surgery. Lateral SCC was the most commonly involved in bony labyrinth seen in 4 (13.3%) patients in both HRCT and surgery. Erosion of dural plate was seen in 6 (20%) patients in HRCT whereas 9 (30%) patients showed dural plate erosion at surgery.Conclusions: HRCT of temporal bone plays a promising role in pre-operative assessment of cholesteatoma as it depicts the extent of the disease and integrity of most of the middle ear structures.
Dexmedetomidine and fentanyl for epidural analgesia in lower limb orthopedic surgeries: a comparative evaluation
Authors: Kumar Surendra , . Pravina 
Published: March 2019

Background: Epidural anesthesia is the most frequently used technique for providing operative analgesia in lower abdominal and limb surgeries. This study aimed at comparative evaluation of dexmedetomidine and fentanyl for epidural anaesthesia in lower limb orthopedic surgeries.Methods: This study was conducted in the department of Anesthesiology and critical care Medicine, MLB Medical College Jhansi. Patients undergoing lower limb orthopaedic surgery aged between 21 to 50 years and belonging to American Society of Anaesthesiologist (ASA) grade 1or 2 were included. Informed and written consent was obtained. Subjects were divided into two groups. Statistical analysis was done using SPSS version 16.0 software. t-test, Chi-square test, and Mann-Whitney tests were applied.Results: Age wise distribution, body weight and mean duration of surgical time was comparable in both groups and found statistically insignificant. Time to achieve sensory level at T10 was found to be significantly less in Group RD as compared to Group RF. Early onset of motor block in Group RD was seen (10.12min) as compared to fentanyl (13.36min). Complete motor block was achieved in significantly lower time by Group RD as compared to Group RF. Duration of motor block was significantly higher in Group RD as compared to Group RF subjects. Better sedation score was found in Group RD.Conclusions: Dexmedetomidine is better as an adjuvant to ropivacaine than fentanyl for epidural anaesthesia because of intense analgesia, better quality of motor block and prolong post-operative analgesia, along with higher sedation scores.
Kobi’lerin Finansal Sorunlarının İncelenmesinde Dış Kaynak Sermayesinin Rolü: Diyarbakır İli Örneği
Authors: SEZGİN Eray Ekin 
Published: March 2019

Çalışmamızda,
Diyarbakır ilinde faaliyet gösteren 386 adet KOBİ üzerinde dış kaynakdan temin
edilen krediler ve bunların işletmede yarattığı sorunlar ortaya konulmaya
çalışılmıştır. Yapılan çalışmanın sonuçlarını şu çerçevede
özetleyebiliriz. İşletmelerin büyük bir
bölümünün kredilerle finansman sağladıkları ve bu kredilerin büyük bir kısmını
bankalardan temin ettikleri görülmüştür. Bu bağlamda işletmelerin KOSGEB’in
kredilerinden yeterince yararlanmadıkları tespiti yapılmış, bunun nedeninin de
kamu borcu olan işletmelerin aldığı krediden borcu kadar kesinti yapılmasıdır.
Kredi kullanan işletmeler, kredi kullanımında yaşadığı zorlukların önemli bir
bölümünü teminat sağlama ve formalite- şekil şartları olarak ifade etmişlerdir.
Bununla birlikte işletmelerin önemli bir kısmı kredinin miktarı bakımından bir
sorun ortaya koyamamaktadır.

Çalışmamızdaki veriler,
istatistiksel bir ortamda değerlendirilmiş ve kurulan hipotezlerin test
edilmesi bu çerçevede gerçekleştirilmiştir.
DISPARITY OF IMPLEMENTATION OF REGIONAL CULTURE AS CHARACTER EDUCATION IMPLEMENTATION IN CITY WORTH CHILDREN
Authors: Supeni Siti , Nurati Dian Esti , Sufa Feri Faila 
Published: March 2019

<p>The research objective was to analyze the needs and attitudes of children in implementing regional culture-based character education as a contribution to the mental revolution in a Child-Friendly City, seen from the aspects of art, recreation, and competition. The research subjects consisted of; teachers, bureaucrats, parents, 20 respondents. Research methods through literature study, interviews, observation, and documentation. Analysis of data on regional cultural development based on character education is supported by psychological, educational, and socio-cultural approaches, with qualitative descriptive analysis.</p><p>The results of the study show that the School has artifacts (symbols) bearing regional cultural art in accordance with the development of the age of the child, in the city of Surakarta: 63%, in the city of Denpasar: 93%, in the city of West Jakarta: 60%. 60%, Denpasar: 100%, and in the city of West Jakarta: 33%. compulsory education program in three cities; 93%, Bali, 95.5% Surakarta, and West Jakarta 90%. In conclusion all have followed the Child Friendly City program.</p><p> </p><p>Keywords: regional culture, character education, child-friendly city.</p>
Enteroarticular Fistula Following Antibiotic Spacer Placement for a Periprosthetic Joint Infection in a Patient with Chronic Pelvic Discontinuity
Authors: Dardas Agnes Z. , Bindon Joshua M. , Klyde Daniel , Gittings Daniel J. , Sheth Neil P. 
Published: March 2019

Case:
A 50-year-old man with a history of chronic refractory periprosthetic joint infection following total hip arthroplasty, which had been treated with multiple antibiotic spacers, developed an enteroarticular fistula. He was able to avoid hip disarticulation after undergoing a laparoscopic colectomy with a diverting colostomy and a functional hip resection arthroplasty. At the 1-year follow-up, he was walking independently with crutches and had minimal pain.

Conclusion:
An enteroarticular fistula following total hip arthroplasty is a rare and serious complication. To our knowledge, this is the first reported case that occurred in the setting of an antibiotic spacer. A multidisciplinary team approach is essential for achieving clinical success.
Cardioprotective Effect of Remote Ischemic Preconditioning with Postconditioning on Donor Hearts in Patients Undergoing Heart Transplantation: a single-center, double-blind, randomized controlled trial
Authors: Wang Guyan , Zhang Ying , Yang Lijing , Chen Yimeng , Fang Zhongrong , Zhou Hui , Zhang Congya , Lei Guiyu , Shi Sheng , Li Jun 
Published: March 2019

Abstract
Background

Cardioprotective effect of remote ischemic preconditioning (RIPC) in cardiovascular surgery is controversy. This study investigated whether RIPC combined with remote ischemic postconditioning (RIPostC) reduces myocardial injury on donor hearts in patients undergoing heart transplantation.

Methods

One hundred and twenty patients scheduled for orthotopic heart transplantation were enrolled and randomly assigned to an RIPC+RIPostC group (n=60) or a control (n=60) group. In the RIPC+RIPostC group, four cycles of 5-min ischemia and 5-min reperfusion were applied on the right upper limb by a cuff inflated to 200mmHg after anesthesia induction (RIPC) and 20 minutes after aortic declamping (RIPostC). Serum cardiac troponin I (cTnI) level was determined preoperatively and at 3, 6, 12, 24 h after aortic declamping. Postoperative clinical outcomes were recorded. The primary endpoint was comparison of the cTnI levels at 6 h after aortic declamping.

Results

Compare with the preoperative baseline, serum cTnI levels peaked at 6h after aortic declamping in two groups. Compare with the control group, RIPC+RIPostC significantly reduced the serum cTnI levels at 6h after aortic declamping (38.87±31.81 vs 69.30±34.13ng/ml, P=0.018). There was no significant difference in in-hospital morbidity and mortality between the two groups.

Conclusion

In patients undergoing orthotopic heart transplantation, RIPC combined with RIPostC reduced myocardial injury at 6h after aortic declamping,while we found no evidence of this function provided by RIPC+RIPostC could improve clinical outcomes
Effects of dexamethasone on postoperative cognitive dysfunction and delirium in adults following general anesthesia: a meta-analysis of randomized controlled trials
Authors: Li Li-Qin , Wang Cong , Fang Mei-Dan , Xu Hong-Yu , Lu Hong-Liu , Zhang Hou-Zhong 
Published: March 2019

Abstract
Background Several studies have investigated the effects of dexamethasone on postoperative cognitive dysfunction (POCD) or postoperative delirium (POD); however, their conclusions have not been consistent. So we conducted a meta-analysis to determine the effects of dexamethasone on POCD/POD in adults following general anesthesia. Methods Cochrane Central Register of Controlled Trials (CENTRAL, 2018, Issue 11 of 12) in the Cochrane Library (searched November 17, 2018); MEDLINE OvidSP (1946 to November 16, 2018); and Embase OvidSP (1974 to November 16, 2018) were searched for randomized controlled trials that evaluated the incidence of POCD/POD following dexamethasone administration, in adults (age ≥18 years) under general anesthesia. We used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework to assess the quality of evidence. Results Five studies were included (three studies/855 participants in dexamethasone group and 538 participants in placebo group for the incidence of POCD, and two studies/410 participants in dexamethasone group and 420 participants in placebo group for the incidence of POD). There was no significant difference between the dexamethasone group and the placebo group in terms of the incidence of POCD in 30 days after surgery (RR 1.00; 95% CI [0.51, 1.96], P = 1.00, I2 = 77%) or in the incidence of POD (RR 0.96; 95% CI [0.68, 1.35], P = 0.80, I2 = 0%). However, both analyses had some limitations since evidence remains limited and clinical heterogeneity, and we considered the quality of the evidence for the postoperative incidence of POCD and POD to be very low. Conclusions This meta-analysis revealed that prophylactic dexamethasone did not reduce the incidence of POCD and POD. Trials of alternative prevent strategies for POCD/POD, and a better understanding of the pathophysiology of those complex syndrome, are still needed to make progress of this field. Trial registration number: This study is registered with PROSPERO, 23 October 2018, number CRD42018114552.
The role of p66Shc in high glucose concentration-induced oxidative damage in R28 cells
Authors: Zhao Minghui , Wu Qiang , Hu Jianyan , Lu Peirong 
Published: March 2019

Abstract
Purpose: To investigate the effect of high glucose concentrations on the expression of p66Shc and phosphorylation of p66Shc Ser36 in R28 cells, and to elucidate the role of p66Shc in high glucose-induced oxidative damage and apoptosis of R28 cells.
Methods: R28 cells were cultured with various concentrations of D-glucose, or with 30 mM D-glucose or 30 mM mannitol only for the indicated timepoints. The expression of p66Shc and phosphorylation of p66Shc Ser36 were subsequently detected. Additionally, R28 cells were divided into five groups: i. control (CTL) group; ii. high glucose (HG) group; iii. high glucose p66Shc Wt (HG p66Shc Wt) group; iv. high glucose p66Shc siRNA (HG p66Shc siRNA) group; and v. high glucose p66Shc S36A (HG p66Shc S36A) group. P66Shc, cytochrome C, and reactive oxygen species (ROS) content in mitochondria, mitochondrial membrane potential levels, mitochondrial DNA damage, and apoptosis were also evaluated.
Results: With the increase of glucose concentration, the levels of p66Shc mRNA and expression of p66Shc protein gradually increased. P66Shc mRNA and protein levels, and phosphorylation of p66Shc Ser36 increased with the prolongation of exposure to high concentrations of glucose. Notably, after stimulation with 30 mM mannitol, the levels of p66Shc mRNA, p66Shc protein, and p66Shc S36 phosphorylation did not change. With the increase of p66Shc level in the mitochondria of R28 cells, ROS content in mitochondria increased, mitochondrial membrane potential decreases, mitochondrial DNA damage was exacerbated, cytochrome C content in mitochondria decreased, and apoptosis increased.
Conclusion: High glucose concentrations increased the expression of p66Shc in R28 cells in a time- and concentration-dependent manner. P66Shc is an essential regulator of mitochondrial ROS, and play an important role in mitochondrial apoptosis.