bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Selective Supported Graphene Oxide Membranes for Water-Ethanol Separation
Authors: Shin Yongsoon , Taufique Mohammad Fuad Nur , Devanathan Ram , Cutsforth Erika C. , Lee Jaewon , Liu Wei , Fifield Leonard S. , Gotthold David W. 
Published: February 2019

AbstractA polyethersulfone (PES)-supported graphene oxide (GO) membrane has been developed by a simple casting approach. This stable membrane is applied for ethanol/water separation at different temperatures. The 5.0 µm thick GO film coated on PES support membrane showed a long-term stability over a testing period of one month and excellent water/ethanol selectivity at elevated temperatures. The water/ethanol selectivity is dependent on ethanol weight percentage in water/ethanol feed mixtures and on operating temperature. The water/ethanol selectivity was enhanced with an increase of ethanol weight percentage in water/ethanol mixtures, from below 100 at RT to close to 874 at a 90 °C for 90% ethanol/10% water mixture. Molecular dynamics simulation of water-ethanol mixtures in graphene bilayers, that are considered to play a key role in transport, revealed that molecular transport is negligible for layer spacing below 1 nm. The differences in the diffusion of ethanol and water in the bilayer are not consistent with the large selectivity value experimentally observed. The entry of water and ethanol into the interlayer space may be the crucial step controlling the selectivity.
Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia
Authors: Bousman Chad A. , Luza Sandra , Mancuso Serafino G. , Kang Dali , Opazo Carlos M. , Mostaid Md. Shaki , Cropley Vanessa , McGorry Patrick , Shannon Weickert Cynthia , Pantelis Christos , Bush Ashley I. , Everall Ian P. 
Published: February 2019

AbstractDysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (38 schizophrenia, 38 control) matched individuals, as well as erythrocytes from 181 living participants, who comprised 30 individuals with recent onset schizophrenia (mean illness duration = 1 year), 63 individuals with ‘treatment-resistant’ schizophrenia (mean illness duration = 17 years), and 88 age-matched participants without major psychiatric illness. Ubiquitinated protein levels were elevated in postmortem OFC in schizophrenia compared to controls (p = <0.001, AUC = 74.2%). Similarly, individuals with ‘treatment-resistant’ schizophrenia had higher levels of ubiquitinated proteins in erythrocytes compared to those with recent onset schizophrenia (p < 0.001, AUC = 65.5%) and controls (p < 0.001, AUC = 69.4%). The results could not be better explained by changes in proteasome activity, demographic, medication, or tissue factors. Our results suggest that ubiquitinated protein formation may be abnormal in both the brain and erythrocytes of those with schizophrenia, particularly in the later stages or specific sub-groups of the illness. A derangement in protein ubiquitination may be linked to pathogenesis or neurotoxicity in schizophrenia, and its manifestation in the blood may have prognostic utility.
Preoperative Prediction of Axillary Lymph Node Metastasis in Breast Cancer using Radiomics Features of DCE-MRI
Authors: Cui Xiaoyu , Wang Nian , Zhao Yue , Chen Shuo , Li Songbai , Xu Mingjie , Chai Ruimei 
Published: February 2019

AbstractThe accurate and noninvasive preoperative prediction of the state of the axillary lymph nodes is significant for breast cancer staging, therapy and the prognosis of patients. In this study, we analyzed the possibility of axillary lymph node metastasis directly based on Magnetic Resonance Imaging (MRI) of the breast in cancer patients. After mass segmentation and feature analysis, the SVM, KNN, and LDA three classifiers were used to distinguish the axillary lymph node state in 5-fold cross-validation. The results showed that the effect of the SVM classifier in predicting breast axillary lymph node metastasis was significantly higher than that of the KNN classifier and LDA classifier. The SVM classifier performed best, with the highest accuracy of 89.54%, and obtained an AUC of 0.8615 for identifying the lymph node status. Each feature was analyzed separately and the results showed that the effect of feature combination was obviously better than that of any individual feature on its own.
A dicentric chromosome identification method based on clustering and watershed algorithm
Authors: Shen Xiang , Qi Yafeng , Ma Tengfei , Zhou Zhenggan 
Published: February 2019

AbstractAiming at the problem of low efficiency of dicentric chromosome identification counting under the microscope, this paper presents a joint processing algorithm combining clustering and watershed. The method first uses clustering and watershed algorithm to segment the original chromosome image, and then identifies the individual chromosomes. The results show that when the equivalent width Y parameter is selected m = 1, n = 1, the true positive rate of dicentric chromosome identification is 76.6%, and positive predictive value is 76.6% in high dose, which is higher than the threshold algorithm for the true positive rate (63.9%) and positive predictive value (63.5%). The number of identified dicentric chromosomes can be used for dose estimation. When 500 cells are used for identification and dose estimation, the dose estimation pass rate can reach 80% in high dose. But for low dose, more cells should be used to identify to increase the dose estimation pass rate.
tDCS-induced episodic memory enhancement and its association with functional network coupling in older adults
Authors: Antonenko Daria , Hayek Dayana , Netzband Justus , Grittner Ulrike , Flöel Agnes 
Published: February 2019

AbstractTranscranial direct current stimulation (tDCS) augments training-induced cognitive gains, an issue of particular relevance in the aging population. However, negative outcomes have been reported as well, and few studies so far have evaluated the impact of tDCS on episodic memory formation in elderly cohorts. The heterogeneity of previous findings highlights the importance of elucidating neuronal underpinnings of tDCS-induced modulations, and of determining individual predictors of a positive response. In the present study, we aimed to modulate episodic memory formation in 34 older adults with anodal tDCS (1 mA, 20 min) over left temporoparietal cortex. Participants were asked to learn novel associations between pictures and pseudowords, and episodic memory performance was subsequently assessed during immediate retrieval. Prior to experimental sessions, participants underwent resting-state functional magnetic resonance imaging. tDCS led to better retrieval performance and augmented learning curves. Hippocampo-temporoparietal functional connectivity was positively related to initial memory performance, and was positively associated with the magnitude of individual tDCS-induced enhancement. In sum, we provide evidence for brain stimulation-induced plasticity of episodic memory processes in older adults, corroborating and extending previous findings. Our results demonstrate that intrinsic network coupling may determine individual responsiveness to brain stimulation, and thus help to further explain variability of tDCS responsiveness in older adults.
Human renal fibroblasts are strong immunomobilizers during a urinary tract infection mediated by uropathogenic Escherichia coli
Authors: Klarström Engström Kristin , Zhang Boxi , Demirel Isak 
Published: February 2019

AbstractTo prevent the onset of urosepsis and reduce mortality, a better understanding of how uropathogenicEscherichia coli(UPEC) manages to infiltrate the bloodstream through the kidneys is needed. The present study elucidates if human renal interstitial fibroblasts are part of the immune response limiting a UPEC infection, or if UPEC has the ability to modulate the fibroblasts for their own gain. Microarray results showed that upregulated genes were associated with an activated immune response. We also found that chemokines released from renal fibroblasts upon a UPEC infection could be mediated by LPS and triacylated lipoproteins activating the TLR2/1, TLR4, MAPK, NF-κB and PKC signaling pathways. Furthermore, UPEC was also shown to be able to adhere and invade renal fibroblasts, mediated by the P-fimbriae. Furthermore, it was found that renal fibroblasts were more immunoreactive than renal epithelial cells upon a UPEC infection. However, both renal fibroblasts and epithelial cells were equally efficient at inducing neutrophil migration. In conclusion, we have found that human renal fibroblasts can sense UPEC and mobilize a host response with neutrophil migration. This suggests that renal fibroblasts are not only structural cells that produce and regulate the extracellular matrix, but also highly immunoreactive cells.
Calculation of π and Classification of Self-avoiding Lattices via DNA Configuration
Authors: Tandon Anshula , Kim Seungjae , Song Yongwoo , Cho Hyunjae , Bashar Saima , Shin Jihoon , Ha Tai Hwan , Park Sung Ha 
Published: February 2019

AbstractNumerical simulation (e.g. Monte Carlo simulation) is an efficient computational algorithm establishing an integral part in science to understand complex physical and biological phenomena related with stochastic problems. Aside from the typical numerical simulation applications, studies calculating numerical constants in mathematics, and estimation of growth behavior via a non-conventional self-assembly in connection with DNA nanotechnology, open a novel perspective to DNA related to computational physics. Here, a method to calculate the numerical value of π, and way to evaluate possible paths of self-avoiding walk with the aid of Monte Carlo simulation, are addressed. Additionally, experimentally obtained variation of the π as functions of DNA concentration and the total number of trials, and the behaviour of self-avoiding random DNA lattice growth evaluated through number of growth steps, are discussed. From observing experimental calculations of π (πexp) obtained by double crossover DNA lattices and DNA rings, fluctuation of πexptends to decrease as either DNA concentration or the number of trials increases. Based upon experimental data of self-avoiding random lattices grown by the three-point star DNA motifs, various lattice configurations are examined and analyzed. This new kind of study inculcates a novel perspective for DNA nanostructures related to computational physics and provides clues to solve analytically intractable problems.
Extreme spikes in DMS flux double estimates of biogenic sulfur export from the Antarctic coastal zone to the atmosphere
Authors: Webb A. L. , van Leeuwe M. A. , den Os D. , Meredith M. P. , J. Venables H. , Stefels J. 
Published: February 2019

AbstractBiogenic dimethylsulfide (DMS) is a significant contributor to sulfur flux from the oceans to the atmosphere, and the most significant source of aerosol non sea-salt sulfate (NSS-SO42−), a key regulator of global climate. Here we present the longest running time-series of DMS-water (DMSW) concentrations in the world, obtained at the Rothera Time-Series (RaTS) station in Ryder Bay, West Antarctic Peninsula (WAP). We demonstrate the first ever evaluation of interseasonal and interannual variability in DMSW and associated flux to the atmosphere from the Antarctic coastal zone and determine the scale and importance of the region as a significant source of DMS. Impacts of climate modes such as El Niňo/Southern Oscillation are evaluated. Maximum DMSW concentrations occurred annually in January and were primarily associated with sea-ice break-up. These concentrations resulted in extremely high (up to 968 µmol m−2 d−1) DMS flux over short timescales, which are not parameterised in global-scale DMS climatologies. Calculated DMS flux stayed above the aerosol nucleation threshold of 2.5 µmol m−2 d−1 for 60% of the year. Overall, using flux determinations from this study, the total flux of DMS-sulfur from the Austral Polar Province (APLR) was 1.1 Tg sulfur yr−1, more than double the figure suggested by the most recent DMS climatologies.
The effect of psychopathy on cooperative strategies in an iterated Prisoner’s Dilemma experiment with emotional feedback
Authors: Testori Martina , Harris Thehela O. A. , Hoyle Rebecca B. , Eisenbarth Hedwig 
Published: February 2019

AbstractAs decision-making research becomes more popular, the inclusion of personality traits has emerged as a focal point for an exhaustive analysis of human behaviour. In this study, we investigate the impact of psychopathic traits on cooperation in an iterated Prisoner’s Dilemma game with emotional facial feedback. Firstly, we observed how receiving a facial feedback after each decision affected players with different psychopathic trait scores, and how being informed about the opponent’s identity influenced cooperative behaviour. Secondly, we analysed the strategies adopted by each player, and how these choices were correlated with their psychopathic traits. Although our results showed no effect of different emotional content in the feedback on cooperation, we observed more cooperative behaviours in those players who were told their opponent was another fellow human, compared to those who were told it was a computer. Moreover, fearless dominance had a very small but consistent negative effect on overall cooperation and on the tendency to maintain cooperative behaviours. We also found that players’ personality scores affected the strategies they chose to play throughout the game. Hence, our experiment adds complexity to the body of work investigating psychopathic traits and social interactions, considering not only the environment of facial feedback but also the role of deception in experimental games.
Fatigue Behavior of Inorganic-Organic Hybrid “Lunar Cement”
Authors: Su Hang , Hong Youshi , Chen Tzehan , Kou Rui , Wang Meng , Zhong Ying , Qiao Yu 
Published: February 2019

AbstractWe report the experimental results of fatigue behavior of ultralow-binder-content inorganic-organic hybrid (IOH) based on lunar soil simulant, which may be viewed as a “lunar cement”. Under the same loading condition, the fatigue life of the IOH is superior to typical steel-reinforced concrete, especially when the stress amplitude is relatively high. Fatigue damage mostly occurs in the binder phase, followed by rapid cleavage-like failure. The important material parameters include filler type, filler particle size, and filler-binder bonding.
Direct Detection of Akhiezer Damping in a Silicon MEMS Resonator
Authors: Rodriguez Janna , Chandorkar Saurabh A. , Watson Christopher A. , Glaze Grant M. , Ahn C. H. , Ng Eldwin J. , Yang Yushi , Kenny Thomas W. 
Published: February 2019

AbstractSilicon Microelectromechanical Systems (MEMS) resonators have broad commercial applications for timing and inertial sensing. However, the performance of MEMS resonators is constrained by dissipation mechanisms, some of which are easily detected and well-understood, but some of which have never been directly observed. In this work, we present measurements of the quality factor, Q, for a family of single crystal silicon Lamé-mode resonators as a function of temperature, from 80–300 K. By comparing these Q measurements on resonators with variations in design, dimensions, and anchors, we have been able to show that gas damping, thermoelastic dissipation, and anchor damping are not significant dissipation mechanisms for these resonators. The measured f · Q product for these devices approaches 2 × 1013, which is consistent with the expected range for Akhiezer damping, and the dependence of Q on temperature and geometry is consistent with expectations for Akhiezer damping. These results thus provide the first clear, direct detection of Akhiezer dissipation in a MEMS resonator, which is widely considered to be the ultimate limit to Q in silicon MEMS devices.
Flexible updating of dynamic knowledge structures
Authors: Richter Franziska R. , Bays Paul M. , Jeyarathnarajah Priyanga , Simons Jon S. 
Published: February 2019

AbstractSchemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information. The usefulness of schemas, however, critically depends on their adaptability: how flexibly a schema can be updated according to changing environmental conditions. Prior consolidation of a schema supports new learning of schema-consistent information. Yet, the effect of consolidation on inconsistent information, and how schemas may be subsequently updated, are not well understood. It is difficult to track the dynamic updating of knowledge structures with traditional memory measures. Here, using a continuous-report paradigm, we were able to show that schematization increases incrementally with consolidation and that the strength with which schemas are initially established predicts schema-guided responding in a later test. Critically, schema updating in response to inconsistent information was more pronounced in a group which was given time to consolidate compared to a group that was not given time to consolidate. Importantly, the later group reverted back to the no longer relevant schema, indicating that systematic bias towards old information, rather than increased forgetting, underlies reduced memory for schema-inconsistent information.
Monolayer MoS2 field-effect transistors patterned by photolithography for active matrix pixels in organic light-emitting diodes
Authors: Kwon Hyeokjae , Garg Sourav , Park Ji Hoon , Jeong Yeonsu , Yu Sanghyuck , Kim Seongsin M. , Kung Patrick , Im Seongil 
Published: February 2019

AbstractTwo-dimensional molybdenum disulfide (MoS2) has substantial potential as a semiconducting material for devices. However, it is commonly prepared by mechanical exfoliation, which limits flake size to only a few micrometers, which is not sufficient for processes such as photolithography and circuit patterning. Chemical vapor deposition (CVD) has thus become a mainstream fabrication technique to achieve large-area MoS2. However, reports of conventional photolithographic patterning of large-area 2D MoS2-based devices with high mobilities and low switching voltages are rare. Here we fabricate CVD-grown large-area MoS2field-effect transistors (FETs) by photolithography and demonstrate their potential as switching and driving FETs for pixels in analog organic light-emitting diode (OLED) displays. We spin-coat an ultrathin hydrophobic polystyrene layer on an Al2O3dielectric, so that the uniformity of threshold voltage (Vth) of the FETs might be improved. Our MoS2FETs show a high linear mobility of approximately 10 cm2 V−1 s−1, due to a large grain size around 60 μm, and a high ON/OFF current ratio of 108. Dynamic switching of blue and green OLED pixels is shown at ~5 V, demonstrating their application potential.
The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A
Authors: Reelfs Olivier , Abbate Vincenzo , Cilibrizzi Agostino , Pook Mark A , Hider Robert C , Pourzand Charareh 
Published: February 2019

Abstract
Mitochondrial labile iron (LI) is a major contributor to the susceptibility of skin fibroblasts to ultraviolet A (UVA)-induced oxidative damage leading to necrotic cell death via ATP depletion. Mitochondria iron overload is a key feature of the neurodegenerative disease Friedreich's ataxia (FRDA). Here we show that cultured primary skin fibroblasts from FRDA patients are 4 to 10-fold more sensitive to UVA-induced death than their healthy counterparts. We demonstrate that FRDA cells display higher levels of mitochondrial LI (up to 6-fold on average compared to healthy counterparts) and show higher increase in mitochondrial reactive oxygen species (ROS) generation after UVA irradiation (up to 2-fold on average), consistent with their differential sensitivity to UVA. Pre-treatment of the FRDA cells with a bespoke mitochondrial iron chelator fully abrogates the UVA-mediated cell death and reduces UVA-induced damage to mitochondrial membrane and the resulting ATP depletion by a factor of 2. Our results reveal a link between FRDA as a disease of mitochondrial iron overload and sensitivity to UVA of skin fibroblasts. Our findings suggest that the high levels of mitochondrial LI in FRDA cells which contribute to high levels of mitochondrial ROS production after UVA irradiation are likely to play a crucial role in the marked sensitivity of these cells to UVA-induced oxidative damage. This study may have implications not only for FRDA but also for other diseases of mitochondrial iron overload, with the view to develop topical mitochondria-targeted iron chelators as skin photoprotective agents.
Analysis of copper response in Acinetobacter sp. by comparative proteomics
Authors: Gracioso Louise Hase , Baltazar Marcela Passos Galluzzi , Avanzi Ingrid Regina , Karolski Bruno , Oller Nascimento Claudio Augusto , Perpetuo Elen Aquino 
Published: February 2019

Abstract
Metal contamination exerts environmental pressure on several lifeforms. Since metals are non-biodegradable and recalcitrant, they accumulate in living beings and spread through the food chain. Thus, many life forms are affected by environmental metal contamination, such as plants and microorganisms. In the case of microorganisms, scarce information is available on how metals affect them. As a highly resistant form of life, microorganisms can adapt to several environmental pressures through genetic modifications, changing their metabolism to overcome new conditions, and continuing to thrive in the same place. In this study, an Acinetobacter sp. strain was isolated from a copper mine, which presented very high resistance to copper, growing in copper concentrations of up to 7 mM. As a result of its metabolic response in the presence of 3 mM of copper, the expression of 35 proteins in total was altered. The proteins were identified to be associated with the glycolytic pathway, membrane transport, biosynthesis and two proteins directly involved in copper homeostasis (CopA and CopB).
Investigation of dacomitinib on reducing cell necrosis and enhancing cell apoptosis in C6 glioma rat model by MRI
Authors: Chen Wang-Sheng , Hong Lan , Wang Fei , Li Jian-Jun 
Published: February 2019

Abstract
Background: Glioma is one of the most epidemic and obstinate types of cancer in the central nervous system (CNS) with poor survival rate. Dacomitinib inhibited cell viability and proliferation of epidermal growth factor receptor (EGFR)-amplified glioma. In the present study, the regional effects of Dacomitinib on tumor necrosis was investigated. Methods: A C6 rat glioma model was evaluated using proton magnetic resonance spectroscopy (1H-MRS), diffusion weighted imaging (DWI), and morphological T2-weighted imaging (T2W). The effects of Dacomitinib on glioma cells were investigated using methods of immunohistochemistry and Hematoxylin and Eosin (H&E) staining. Results: The obtained data indicated that metabolite ratios were significantly decreased (all P&lt;0.05) in the Dacomitinib-treated group compared with C6 glioma control group. The ADC value of necrotic core in Dacomitinib group was significantly lower than that in control group. In addition, the expression of Ki-67 in Dacomitinib-treated group (50.32 ± 5.61) was significantly lower than that in control group (P&lt;0.05). The apoptotic index (AI) (28.01 ± 2.37) in Dacomitinib-treated group was significantly higher than that in control group (11.58 ± 3.17). Conclusion: The results demonstrated that the Dacomitinib could suppress glioma cell necrosis and proliferation.