bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of surgical site infection on survival after limb amputation in the curative‐intent treatment of canine appendicular osteosarcoma: a Veterinary Society of Surgical Oncology retrospective study
Authors: Hans Eric C. , Pinard Chris , van Nimwegen S. A. , Kirpensteijn Jolle , Singh Ameet , MacEachern Steven , Naber Steven , Dudley Robert M. 
Published: October 2018

AbstractObjectiveTo determine the influence of surgical site infection (SSI) on the median disease‐free interval (DFI) and median survival time (MST) in dogs after amputation in the curative‐intent treatment of appendicular osteosarcoma (OSA).Study designMulti‐institutional retrospective cohort study.AnimalsFifteen dogs with OSA and SSI, and 134 dogs with OSA and no SSI.MethodsMedical records were reviewed, and dogs were included if the following criteria were met: histologic confirmation of OSA, no evidence of metastasis, ≥1 chemotherapy treatment, and available follow‐up data. We used the definition of SSI from the Centers for Disease Control and Prevention. Kaplan‐Meier estimates of median DFI and MST for the SSI and non‐SSI groups were compared by log‐rank test. Univariate and multivariate Cox proportional hazard regression analysis was evaluated for associations with DFI and survival.ResultsThe median DFI and MST of all OSA dogs were 236 days (95% CI, 181‐283) and 283 days (95% CI 237‐355), respectively. The median DFI of dogs with SSI (292 days) did not differ from that of dogs without SSI (224 days, P = .156). The MST of dogs with SSI (292 days) did not differ from that of dogs without SSI (280 days, P = .417). Failure to complete chemotherapy was associated with decreased DFI and survival (P < .001). Adjustments for chemotherapy completion found no effect of SSI on survival.ConclusionSSI did not influence the survival of dogs with appendicular OSA treated with amputation and curative‐intent treatment.Clinical significanceThe extended survival associated with SSI after limb‐spare surgery for OSA does not appear to be present after amputation. Interactions between the canine immune system and OSA warrant additional study.
Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname
Authors: Zonneveld Rens , Jongman Rianne M , Juliana Amadu , Molema Grietje , van Meurs Matijs , Plötz Frans B 
Published: October 2018

BackgroundEarly onset sepsis (EOS) is defined as onset of sepsis within 72 hours after birth. Leucocyte-endothelial interactions play a pivotal part in EOS pathophysiology. Endothelial cell adhesion molecules (CAMs) orchestrate these interactions and their soluble isoforms (sCAMs) are released into the vasculature by enzymes called sheddases.PurposeThis study was undertaken to explore further the pathophysiology of EOS and to investigate the potential of sCAM and their sheddases as potential biomarkers for EOS.MethodsStored serum aliquots were used from 71 Surinamese newborns suspected of EOS and 20 healthy newborns from an earlier study. Serum had been collected within 72 hours after birth and six (8.6%) newborns had a positive blood culture with gram-negative pathogens. Concentrations of sCAMs sP-selectin, sE-selectin, soluble vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 and platelet and endothelial cell adhesion molecule-1, sheddases matrix metalloproteinase-9 (MMP-9) and neutrophil elastase (NE) and sheddase antagonist tissue-inhibitor of metalloproteinases-1 (TIMP-1) were measured simultaneously with Luminex and ELISA.ResultsMMP-9 and TIMP-1 levels were measured in serum of n=91 newborns and sCAMs and NE levels in serum of n=80 newborns, respectively. We found no differences in median concentrations of sCAMs, MMP-9 and TIMP-1 or NE between blood culture positive EOS, blood culture negative EOS and control groups at start of antibiotic treatment.ConclusionsOur data indicate that serum concentrations of sCAMs and their sheddases have no clinical utility as biomarkers for EOS.Trial registration numberNCT02486783. Results
Effect of heating rate, impurity concentration of Cu, atomic number, temperatures, time annealing temperature on the structure, crystallization temperature and crystallization process of Ni1−xCux bulk;x= 0.1, 0.3, 0.5, 0.7
Authors: Tuan Tran Quoc , Dung Nguyen Trong 
Published: October 2018

This paper studies the effects of heating rate 4 × 10[Formula: see text] K/s, 4 × 10[Formula: see text] K/s, 4 × 10[Formula: see text] K/s; impurity concentration of Cu on Ni[Formula: see text]Cu[Formula: see text] bulk with x = 0.1, x = 0.3, x = 0.5, x = 0.7; atom number (N), N = 4000 atoms, 5324 atoms, 6912 atoms, 8788 atoms at temperatures (T), T = 300 K; N = 6912 atoms at T = 300 K, 400 K, 500 K, 600 K, 700 K, 800 K; N = 6912 atoms at T = 600 K after time annealing temperature (t), t = 500 ps on the structure, crystallization temperature and crystallization process of Ni[Formula: see text]Cu[Formula: see text] bulk by molecular dynamics (MD) method with interactive embedding Sutton–Chen (ST) and periodic boundary conditions. The structural characteristics were analyzed through radial distribution function (RDF), energy total (E[Formula: see text]), size (l) and common neighborhood analysis (CNA) method; temperature (T), crystallization temperature (T[Formula: see text]), crystallization process through relationship between E[Formula: see text], T. The results showed Ni[Formula: see text]Cu[Formula: see text] bulk and links Ni–Ni, Ni–Cu, Cu–Cu always exist in 03 types structures: FCC, HCP, Amor. When time annealing temperature increases then Ni[Formula: see text]Cu[Formula: see text] bulk moves from a crystalline state to an amorphous state. When increases impurity concentration of Cu in Ni[Formula: see text]Cu[Formula: see text] bulk, then the structure unit number FCC, HCP decreases and then increases, structure unit number Amor increases and then decreases. When atom number (N) increases, decreasing T and increasing time annealing temperature lead to structure unit number FCC, HCP increases, Amor decreases and structural, crystallization temperature, crystallization process of Ni[Formula: see text]Cu[Formula: see text] bulk change.
PRKRA/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer
Authors: Hisamatsu Takeshi , McGuire Michael , Wu Sherry Y. , Rupaimoole Rajesha , Pradeep Sunila , Bayraktar Emine , Noh Kyunghee , Hu Wei , Hansen Jean M. , Lyons Yasmin , Gharpure Kshipra M. , Nagaraja Archana S. , Mangala Lingegowda S. , Mitamura Takashi , Rodriguez-Aguayo Cristian , Eun Young Gyu , Rose Johnathon , Bartholomeusz Geoffrey , Ivan Cristina , Lee Ju-Seog , Matsuo Koji , Frumovitz Michael , Wong Kwong K. , Lopez-Berestein Gabriel , Sood Anil K. 
Published: October 2018

Abstract
For mucinous ovarian cancer (MOC), standard platinum-based therapy is largely ineffective. We sought to identify possible mechanisms of oxaliplatin resistance of MOC and develop strategies to overcome this resistance. A kinome-based siRNA library screen was carried out using human MOC cells to identify novel targets to enhance the efficacy of chemotherapy. In vitro and in vivo validations of antitumor effects were performed using mouse MOC models. Specifically, the role of PRKRA/PACT in oxaliplatin resistance was interrogated. We focused on PRKRA, a known activator of PKR kinase, and its encoded protein PACT because it was one of the five most significantly downregulated genes in the siRNA screen. In orthotopic mouse models of MOC, we observed a significant antitumor effect of PRKRA siRNA plus oxaliplatin. In addition, expression of miR-515-3p was regulated by PACT–Dicer interaction, and miR-515-3p increased the sensitivity of MOC to oxaliplatin. Mechanistically, miR-515-3p regulated chemosensitivity, in part, by targeting AXL. The PRKRA/PACT axis represents an important therapeutic target in MOC to enhance sensitivity to oxaliplatin.
Playing Music in Just Intonation: A Dynamically Adaptive Tuning Scheme
Authors: Stange Karolin , Wick Christoph , Hinrichsen Haye 
Published: October 2018

Abstract
We investigate a dynamically adaptive tuning scheme for microtonal tuning of musical instruments, allowing the performer to play music in just intonation in any key. Unlike other methods, which are based on a procedural analysis of the chordal structure, our tuning scheme continually solves a system of linear equations, rather than relying on sequences of conditional if-then clauses. In complex situations, where not all intervals of a chord can be tuned according to the frequency ratios of just intonation, the method automatically yields a tempered compromise. We outline the implementation of the algorithm in an open-source software project that we have provided to demonstrate the feasibility of the tuning method.
Introduction: Archives, Record Keeping and Imperial Governance, 1500-1800
Authors: Donato Maria Pia 
Published: October 2018

Abstract
In the last decades, a vast body of literature has scrutinized the archive, regarding it as an instrument of power for the Western conquest of the world. More recently, a new, vibrant cultural history of archives has changed our understanding of archives as a fully-fledged historical object and why they matter for extending the geographical scope of history and achieving a more connected image of modernity. The articles assembled in this themed issue delve into the history of imperial archives and archival practices in the period 1500-1800, bringing together different lines of inquiry. Each contribution focuses on a major Western imperial formation at different epochs in their evolution, dealing both with current records and historical collections; each engages with archives as an institution, as assemblages of documents that circulated in and out of official depositories, as a site where colonial administrative knowledge was elaborated, and as a political project.
Standing to Hold Responsible
Authors: Edwards James 
Published: October 2018

Abstract
We often hold others responsible, and are held responsible ourselves. Many philosophers claim that to evaluate such holdings, we must consider the standing of the holder. Many also claim that both hypocrites and meddlers lack standing. Little has been said, however, about what exactly standing is—about what it is that hypocrites and meddlers are supposed to lack. Though talk of standing is now widespread, ‘we do not,’ in Joseph Raz’s words, ‘have an unproblematic grasp of the phenomena referred to’ by such talk. In this paper I attempt to improve that grasp. I offer an account of what it is to have, and lack, standing to hold others responsible. And I offer some reasons why, if this account is accepted, both hypocrites and meddlers should lack standing.
The Relationship between Paleography and Textual Criticism: Textual Variants Due to Graphic Similarity between the Masoretic Text and the Samaritan Pentateuch as a Test Case
Authors: Dayfani Hila 
Published: October 2018

AbstractAlmost from the inception of the textual analysis of the Hebrew Bible, scholars recognized that certain textual variants were caused by the interchange of letters bearing graphic similarity. This article focuses on a small number of interchanges between the Masoretic Text (MT) and the Samaritan Pentateuch (SP) and studies their possible paleographic context. The central claim of the paper is that it is possible to identify the scripts used in which the changes occurred and in some instances, even the specific stage of development of the script. The paleographic conclusion that arises from the evidence presented is that the Samaritan version developed from earlier versions that were transmitted in Paleo-Hebrew and in square script, or that the Samaritan version was transmitted in its early stages in both of these scripts. The SP itself reached us in a still later script, the Samaritan script, which developed from the Paleo-Hebrew script.
The Book of Samuel in the Cairo Genizah. An Interim and Introductory Report
Authors: Rendsburg Gary A. 
Published: October 2018

AbstractThis article presents sample results of my ongoing research project on the book of Samuel in the Cairo Genizah. Each of the 650+ manuscripts of Samuel found amongst the documents forthcoming from the Cairo Genizah has been read and analyzed, with the goal of identifying textual variants. Special attention is paid to those variant readings which find parallels in the earlier witnesses (Qumran, Septuagint, Peshitta, Targum, Vulgate).
A New Approach to Using the Old Greek in Hebrew Bible Textual Criticism
Authors: Screnock John 
Published: October 2018

AbstractEmanuel Tov’s published methodology for using the Old Greek in textual criticism of the Hebrew Bible has been the gold standard for all such methods. I present a new approach by building on Tov’s methodology. Although Tov accounts for the reality of Hebrew variants within the mind of the translator, he explores the idea only with regards to scribal errors, leaving most changes stemming from “contextual exegesis” to be categorized as inner-translational and inadmissible in the text critical endeavor. I argue for an extension of Tov’s method by considering other ways in which a scribe working in Hebrew could have made the changes commonly attributed to the translator. In contrast to Tov’s method, I suggest we center our use of the Old Greek in textual criticism around one main criterion: if Hebrew can be reconstructed on the basis of clear translation patterns, the evidence should be used in textual criticism.
Scientific Writing: The Predicament of Weather and Climate Scientists in India
Authors: Rajput Abhay S. D. 
Published: October 2018

AbstractWhile writing is integral to science, it gets little attention in formal science education/academics. Such neglect has serious implications for nonnative English-speaking (NNES) scientists. An inability to write effective and efficient manuscripts can considerably delay the publication of new results while reflecting badly on the performance of individual scientists and on institutional productivity. In the multiethnic and multilingual Indian society, NNES scientists may face more linguistic complexities that inhibit clear and precise scientific writing. This article tries to address the predicament of scientific writing among NNES scientists in weather and climate sciences in India. Results from an informal e-mail survey with 80 respondents, mostly drawn from academic and research institutions in India, bolster anecdotal evidence of the difficulties NNES scientists have in writing about their science in research and popular publications. The responses also reflect high levels of interest these scientists have in addressing their communication difficulties. The survey results address the scientists’ perceptions and dilemmas in clear scientific writing as well as their perceived skills and training needs. The article also suggests possible solutions.
Continuity of Care: Perspectives of Uninsured Free Clinic Patients
Authors: Kamimura Akiko , Panahi Samin , Ahmmad Zobayer , Stoddard Mary , Weaver Shannon , Ashby Jeanie 
Published: October 2018

Background: Continuity of care is vital to the success of a health-care system because it improves patient satisfaction and health outcomes, and reduces hospitalizations and emergency room visits. Objective: The purpose of this study was to examine free clinic patients’ perspectives of continuity of care in the United States. Method: A convenience sample of free clinic patients who were the age of 18 or older and spoke English or Spanish participated in a self-administered survey from January to April in 2017 (N = 580). Results: Better instructions from providers were associated with higher levels of continuity of care ( P < .01). Higher levels of stress and worse self-rated general health were related to lower levels of continuity of care ( P < .05 for stress, P < .01 for general health). Being employed was associated with lower levels of continuity of care ( P < .05). Non-US born English speakers and Spanish speakers rated continuity of care higher than US born English speakers ( P < .01). Conclusion: Even if a patient is unable to see the same physician over time, quality instructions from a well-coordinated provider team may enhance continuity of care from patient perspectives. The social context of patients such as working poor individuals is very important for providers to understand in order to identify barriers to continuity of care.
The Primary Formation of a Cationic C10-Pyridinio-Chlorophyll-aDerivative by Chemical/Electrochemical Oxidation and the Physico-Chemical Properties of Regioisomericmeso-Adducts
Authors: Ogasawara Shin , Tamiaki Hitoshi 
Published: October 2018

AbstractA cationic pyridinium group was introduced to a zinc chlorophyll-a derivative at the meso-positions via its (electro)chemically oxidized cationic radical state. The coupling reactions of zinc methyl mesopyropheophorbide-a with pyridine afforded 5-, 10-, and 20-pyridinio-chlorins that were successfully separated by reversed-phase HPLC. Their 1D/2D-NMR showed the major adduct to be the C10–N+C5H5 regioisomer. Substitution with the meso-pyridinio groups red-shifted their visible absorption bands in a solution.
Evaluation of a multi-level intervention to improve postpartum intrauterine device services in Rwanda
Authors: Ingabire Rosine , Nyombayire Julien , Hoagland Alexandra , Da Costa Vanessa , Mazzei Amelia , Haddad Lisa , Parker Rachel , Sinabamenye Robertine , Mukamuyango Jeannine , Smith Julie , Umutoni Victoria , Mork Ellen , Allen Susan , Karita Etienne , Wall Kristin M. 
Published: October 2018

Background. The copper intrauterine device is one of the most safe, effective, and cost-effective methods for preventing unintended pregnancy. It can be used postpartum irrespective of breastfeeding to improve birth spacing and reduce unintended pregnancy and maternal-child mortality. However, this method remains highly underutilized. Methods. We developed a multi-level intervention to increase uptake of the postpartum intrauterine device (PPIUD, defined as insertion up to six weeks post-delivery) in Kigali, Rwanda. High-volume hospitals and health centers were selected for implementation of PPIUD counseling and service delivery. Formative work informed development of a PPIUD counseling flipchart to be delivered during antenatal care, labor and delivery, infant vaccination visits, or in the community. Two-day didactic counseling, insertion/removal, and follow-up trainings were provided to labor and delivery and family planning nurses followed by a mentored practicum certification process. Counseling data were collected in government clinic logbooks. Insertions and follow-up data were collected in logbooks created for the implementation. Data were collected by trained government clinic staff and abstracted/managed by study staff. Stakeholders were involved from intervention development through dissemination of results. Results. Two hospitals (and their two associated health centers) and two additional health centers were selected. In 6-months prior to our intervention, 7.7 PPIUDs/month were inserted on average at the selected facilities. From August 2017-July 2018, we trained 83 counselors and 39 providers to provide PPIUD services. N=9,020 women received one-on-one PPIUD counseling after expressing interest in family planning who later delivered at a selected health facility. Of those, n=2,575 had PPIUDs inserted (average of 214.6 insertions/month), a 29% uptake. Most PPIUDs (62%) were inserted within 10 minutes of delivery of the placenta. Conclusions. This successful, comprehensive intervention has the potential to make a significant impact on PPIUD uptake in Rwanda. The intervention is scalable and adaptable to other sub-Saharan African countries.
Characterization of fecal sludge as biomass feedstock in the southern Indian state of Tamil Nadu
Authors: Barani Viswa , Hegarty-Craver Meghan , Rosario Praveen , Madhavan Prakash , Perumal Prasanna , Sasidaran Sarani , Basil Milan , Raj Antony , Berg Adrian B. , Stowell Andrea , Heaton Camille , Grego Sonia 
Published: October 2018

Background: Transformative sanitation technologies aim to treat fecal sludge (FS) by thermal processes and recover resources from it. There is a paucity of data describing the relevant properties of FS as viable feedstock for thermal treatment in major geographical target areas, such as India. Methods: This study characterized FS collected from septic tanks in two cities located in the Indian southern state of Tamil Nadu. FS samples were obtained at the point of discharge from trucks in Tiruppur (n=85 samples) and Coimbatore (n=50 samples). Additionally, biosolids obtained from sewage treatment plants (STP) in the cities of Coimbatore and Madurai were characterized. Proximate and ultimate analysis as conducted by the fuel industry was carried out. Results: The average higher heating value (HHV) across all FS samples in Tiruppur (13.4 MJ/kg) was much higher than the value for FS in Coimbatore (5.4 MJ/kg), which was partially attributed to the high ash content of 69% in the latter samples. The HHV in the biosolids samples ranged between 10 and 12.2 MJ/Kg. The average total solids (TS) content for FS was 3.3% and 2.0% for Tiruppur and Coimbatore respectively, while the median TS content for the two cities was 2.3% and 1.2%. The heavy metal content of the ash was found to be below the thresholds for land disposal. Conclusions: This is one of the first studies that has systematically characterized fecal sludge in cities in India and determined its calorific content. We expect these data to serve as input data in the design of thermal processes for fecal sludge treatment.
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease
Authors: Tosh Justin L. , Rickman Matthew , Rhymes Ellie , Norona Frances E. , Clayton Emma , Mucke Lennart , Isaacs Adrian M. , Fisher Elizabeth M.C. , Wiseman Frances K. 
Published: October 2018

Background: Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a transgenic mouse involves random integration of exogenous DNA into the host genome that can have the effect of disrupting endogenous gene expression. The J20 mouse model of Alzheimer’s disease (AD) is a transgenic overexpresser of human APP with familial AD mutations and has been extensively utilised in preclinical studies and our aim was to determine the genomic location of the J20 transgene insertion. Methods: We used a combination of breeding strategy and Targeted Locus Amplification with deep sequencing to identify the insertion site of the J20 transgene array. To assess RNA and protein expression of Zbtb20, we used qRT-PCR and Western Blotting. Results: We demonstrate that the J20 transgene construct has inserted within the genetic locus of endogenous mouse gene Zbtb20 on chromosome 16 in an array, disrupting expression of mRNA from this gene in adult hippocampal tissue. Preliminary data suggests that ZBTB20 protein levels remain unchanged in this tissue, however further study is necessary. We note that the endogenous mouse App gene also lies on chromosome 16, although 42 Mb from the Zbtb20 locus. Conclusions: These data will be useful for future studies utilising this popular model of AD, particularly those investigating gene interactions between the J20 APP transgene and other genes present on Mmu16 in the mouse.