bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encephalitozoon cuniculiandVittaforma corneae(Phylum Microsporidia) inhibit staurosporine-induced apoptosis in human THP-1 macrophagesin vitro
Authors: Sokolova Yuliya Y. , Bowers Lisa C. , Alvarez Xavier , Didier Elizabeth S. 
Published: November 2018

AbstractObligately intracellular microsporidia regulate their host cell life cycles, including apoptosis, but this has not been evaluated in phagocytic host cells such as macrophages that can facilitate infection but also can be activated to kill microsporidia. We examined two biologically dissimilar human-infecting microsporidia species,Encephalitozoon cuniculiandVittaforma corneae, for their effects on staurosporine-induced apoptosis in the human macrophage-differentiated cell line, THP1. Apoptosis was measured after exposure of THP-1 cells to live and dead mature organismsviadirect fluorometric measurement of Caspase 3, colorimetric and fluorometric TUNEL assays, and mRNA gene expression profiles using Apoptosis RT2Profiler PCR Array. Both species of microsporidia modulated the intrinsic apoptosis pathway. In particular, liveE. cuniculispores inhibited staurosporine-induced apoptosis as well as suppressed pro-apoptosis genes and upregulated anti-apoptosis genes more broadly thanV. corneae.Exposure to dead spores induced an opposite effect.Vittaforma corneae, however, also induced inflammasome activationviaCaspases 1 and 4. Of the 84 apoptosis-related genes assayed, 42 (i.e. 23 pro-apoptosis, nine anti-apoptosis, and 10 regulatory) genes were more affected including those encoding members of the Bcl2 family, caspases and their regulators, and members of the tumour necrosis factor (TNF)/TNF receptor R superfamily.
Linguistic prescription, ideological structure, and the actuation of linguistic changes: Grammatical gender in French parliamentary debates
Authors: Burnett Heather , Bonami Olivier 
Published: November 2018

ABSTRACTWe present a quantitative study of the linguistic and social factors conditioning the use of grammatical gender with reference to women, focusing on variation in the debates of the French parliament. Two prime ministers of similar political leanings regulated the use of feminine g-gender through identical policies in 1986 and 1998, with no effect on parliamentary speech in the first instance, and dramatic success in the second. We claim that the latter outcome resulted from changes in gender ideologies between these two dates. The 1990s saw the emergence of a new social type for female politicians, which only feminine g-gender can construct. We hypothesize that the 1998 policy was effective because it strengthened existing associations between feminine g-gender and a persona, while the original policy tried to build on ideological structure that was not widespread. We conclude that linguistic prescriptions are only successful if they build on existing ideologies. (Linguistic prescription, gender ideology, grammatical gender, ideological structure)*
Prevalence and risk factors of sleep apnoea in adult patients with CHD
Authors: Harada Gen , Takeuchi Daiji , Inai Kei , Shinohara Tokuko , Nakanishi Toshio 
Published: November 2018

AbstractBackgroundAlthough sleep apnoea is an important disorder associated with cardiac events, data regarding its prevalence and risk factors in adult patients with CHD are limited.MethodsIn this study, patients underwent a sleep study in the hospital. Indications for admission were classified as heart failure, diagnostic catheterisation, interventional catheterisation, or arrhythmia. The prevalence, characteristics, and risk factors of sleep apnoea using a type 3 portable overnight polygraph in adult patients with CHD were evaluated.ResultsThis study comprised 104 patients of median age 36 years with interquartile range of 28–48 years, admitted for heart failure 34% (n = 36), diagnostic catheterisation 26% (n = 27), interventional catheterisation 18% (n = 19), or arrhythmia 22% (n = 23). The prevalence of sleep apnoea, defined as a respiratory disturbance index ≥5, was 63% (n = 63), with a distribution of 37, 16, and 10% for mild (5≤ respiratory disturbance index <15), moderate (15⩽ respiratory disturbance index <30), and severe (respiratory disturbance index ≥30) sleep apnoea, respectively. A large majority of the sleep apnoea cases were categorised as obstructive sleep apnoea (92%, n = 58). The respiratory disturbance index ≥15 group had a significantly higher proportion of male patients and higher body mass index, noradrenaline level, and aortic blood pressure than the group without sleep apnoea (respiratory disturbance index <5). Multi-variable analysis showed that NYHA class ≥II, whose odds ratio 4.36, 95% confidence interval 1.09–20.87, and body mass index ≥25, whose odds ratio 4.29, 95% confidence interval 1.32–15.23, were independent risk factors for a respiratory disturbance index ≥15.ConclusionOur results showed a high prevalence of sleep apnoea in adult patients with CHD. Its unique haemodynamics may be associated with a high prevalence of sleep apnoea. Congestive heart failure and being overweight are important risk factors for sleep apnoea. Management of heart failure and general lifestyle improvements are important for controlling sleep apnoea symptoms in these patients.
Teaching Statistics: Going from Scary, Boring, and Useless to, Well, Something Better
Authors: Bailey Michael A. 
Published: November 2018

ABSTRACTAlthough research methods and statistics play an increasing role in political science and beyond, students all too often find statistics classes intimidating and boring. This need not be the case, however, because statistics classes provide opportunities to pose and answer questions about which students care. This article highlights four steps to making our methods and statistics classes more engaging and meaningful.
An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study
Authors: Hoseinnezhad Masoumeh , Mahdavi Mohammad , Mahdavi Seyyed R. M. , Mahdavizade Mobarake 
Published: November 2018

AbstractPurposeThe purpose of this study was to determine the dose enhancement factor (DEF) of gold nanoparticles in a dosimeter gel and construct percentage depth dose curves, using the Optical CT system and the Monte Carlo simulation model, to determine the effect of increasing the dose caused by increasing the concentration of gold nanoparticles at depths in the gel.Materials and methodsThe Magic-f Gel was made based on the relevant protocol in the physics lab. To determine the amount of the increase in the absorbed dose, the gold nanoparticles were added to the gel and irradiated. An increase in the dose after adding nanoparticles to the gel vials was estimated both with the Optical CT system and by the Monte Carlo simulation method.ResultsDose enhancement curves for doses of 2, 4 and 6 Gy were prepared for gel vials without adding nanoparticles, and nanoparticle gels at concentrations 0·17, 3 and 6 mM. Also, the DEF was estimated. For the 0·17 mM molar gel, the DEF for 2, 4 and 6 Gy was 0·7, 0·743 and 0·801, respectively. For the 3 mM gel, it was 1·98, 2·5 and 2·2, and for the 6 mM gel, it was 37·4, 4·24 and 4·71, respectively.ConclusionThe enhancement of the dose after adding gold nanoparticles was confirmed both by experimental data and by simulation data.
Why the Next Song Matters: Streaming, Recommendation, Scarcity
Authors: DROTT ERIC 
Published: November 2018

AbstractThis article explores how human curation and algorithmic recommendation are figured in cloud-based streaming platforms. In promoting their services as alternatives to illicit file-sharing, platforms such as Spotify, Deezer, and Apple Music have long touted the access they provide to a massive database of music. Yet the effectiveness of appeals to musical plenitude have been thrown into doubt, as high rates of user turnover threaten streaming's economic viability. Curation and recommendation have thus been posited as solutions to this problem, as means of producing and reproducing consumer desire. By attending to the fantasies woven around streaming and music recommendation more specifically, this article highlights the peculiar form of subjectivation at work in the way recommendation hails listeners. The normative listener constructed through such modes of hyper-personalized address is ideally one that is as dynamic and adaptive as the algorithmic systems that adjust to their fluctuating needs, dispositions, and desires.
Response of Palmer Amaranth and Sweetpotato to Flumioxazin/Pyroxasulfone
Authors: Beam Shawn C. , Chaudhari Sushila , Jennings Katherine M. , Monks David W. , Meyers Stephen L. , Schultheis Jonathan R. , Waldschmidt Mathew , Main Jeffrey L. 
Published: November 2018

AbstractStudies were conducted to determine the tolerance of sweetpotato and Palmer amaranth control to a premix of flumioxazin and pyroxasulfone pretransplant (PREtr) followed by (fb) irrigation. Greenhouse studies were conducted in a factorial arrangement of four herbicide rates (flumioxazin/pyroxasulfone PREtr at 105/133 and 57/72 g ai ha–1,S-metolachlor PREtr 803 g ai ha–1, nontreated) by three irrigation timings [2, 5, and 14 d after transplanting (DAP)]. Field studies were conducted in a factorial arrangement of seven herbicide treatments (flumioxazin/pyroxasulfone PREtr at 40/51, 57/72, 63/80, and 105/133 g ha–1, 107 g ha–1flumioxazin PREtr fb 803 g ha–1S-metolachlor 7 to 10 DAP, and season-long weedy and weed-free checks) by three 1.9-cm irrigation timings (0 to 2, 3 to 5, or 14 DAP). In greenhouse studies, flumioxazin/pyroxasulfone reduced sweetpotato vine length and shoot and storage root fresh biomass compared to the nontreated check andS-metolachlor. Irrigation timing had no influence on vine length and root fresh biomass. In field studies, Palmer amaranth control was≥91% season-long regardless of flumioxazin/pyroxasulfone rate or irrigation timing. At 38 DAP, sweetpotato injury was≤37 and≤9% at locations 1 and 2, respectively. Visual estimates of sweetpotato injury from flumioxazin/pyroxasulfone were greater when irrigation timing was delayed 3 to 5 or 14 DAP (22 and 20%, respectively) compared to 0 to 2 DAP (7%) at location 1 but similar at location 2. Irrigation timing did not influence no.1, jumbo, or marketable yields or root length-to-width ratio. With the exception of 105/133 g ha–1, all rates of flumioxazin/pyroxasulfone resulted in marketable sweetpotato yield and root length-to-width ratio similar to flumioxazin fbS-metolachlor or the weed-free checks. In conclusion, flumioxazin/pyroxasulfone PREtr at 40/51, 57/72, and 63/80 g ha–1has potential for use in sweetpotato for Palmer amaranth control without causing significant crop injury and yield reduction.
Use of Airborne In Situ VOC Measurements to Estimate Transit Time Spectrum: An Observation‐Based Diagnostic of Convective Transport
Authors: Luo Zhengzhao Johnny , Pan Laura L. , Atlas Elliot L. , Chelpon Sofia M. , Honomichl Shawn B. , Apel Eric C. , Hornbrook Rebecca S. , Hall Samuel R. 
Published: November 2018

AbstractConvective transport from the marine boundary layer to the upper troposphere (UT) is investigated using airborne in situ measurements of chemical species over the tropical western Pacific. Using 42 volatile organic compounds with photochemical lifetimes ranging from shorter than a day to multiple decades, we derive a transit time spectrum G(t) and the associated modal and mean transit times for the UT air mass over the convectively dominant tropical western Pacific region. G(t) describes relative contributions of air masses transported from the marine boundary layer to the UT via all transport paths with different transit times. We further demonstrate that the volatile organic compound‐derived transit time scale is broadly comparable to that estimated from convective mass flux. The observation‐based transit time spectrum not only provides insights into convective transport pathways, but also has the potential to serve as an effective diagnostic for evaluating the representation of convective transport in global models.
Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits
Authors: Woodward N. C. , Haghani A. , Johnson R. G. , Hsu T. M. , Saffari A. , Sioutas C. , Kanoski S. E. , Finch C. E. , Morgan T. E. 
Published: November 2018

AbstractExposure to traffic-related air pollution (TRAP) is associated with a range of neurodevelopmental disorders in human populations. In rodent models, prenatal TRAP exposure increased depressive behaviors and increased brain microglial activity. To identify cellular mechanisms, we examined adult neurogenesis and the blood–brain barrier (BBB) in relation to cognition and motivated behaviors in rats that were exposed to a nano-sized TRAP subfraction from gestation into adulthood. At age 5 months, exposed male rats had 70% fewer newly generated neurons in the dentate gyrus (DG) of the hippocampus. Microglia were activated in DG and CA1 subfields (35% more Iba1). The BBB was altered, with a 75% decrease of the tight junction protein ZO-1 in the CA1 layer, and twofold more iron deposits, a marker of microhemorrhages. The exposed rats had impaired contextual memory (novel object in context), reduced food-seeking behavior, and increased depressive behaviors (forced swim). Deficits of de novo neurogenesis were inversely correlated with depressive behavior, whereas increased microbleeds were inversely correlated with deficits in contextual memory. These findings give the first evidence that prenatal and early life exposure to TRAP impairs adult hippocampal neurogenesis and increases microbleeds in association with behavioral deficits.
Sustainable production of highly conductive multilayer graphene ink for wireless connectivity and IoT applications
Authors: Pan Kewen , Fan Yangyang , Leng Ting , Li Jiashen , Xin Zhiying , Zhang Jiawei , Hao Ling , Gallop John , Novoselov Kostya S. , Hu Zhirun 
Published: November 2018

AbstractPrinted electronics offer a breakthrough in the penetration of information technology into everyday life. The possibility of printing electronic circuits will further promote the spread of the Internet of Things applications. Inks based on graphene have a chance to dominate this technology, as they potentially can be low cost and applied directly on materials like textile and paper. Here we report the environmentally sustainable route of production of graphene ink suitable for screen-printing technology. The use of non-toxic solvent Dihydrolevoglucosenone (Cyrene) significantly speeds up and reduces the cost of the liquid phase exfoliation of graphite. Printing with our ink results in very high conductivity (7.13 × 104 S m−1) devices, which allows us to produce wireless connectivity antenna operational from MHz to tens of GHz, which can be used for wireless data communication and energy harvesting, which brings us very close to the ubiquitous use of printed graphene technology for such applications.
Tracking plasma DNA mutation dynamics in estrogen receptor positive metastatic breast cancer with dPCR-SEQ
Authors: Kumar Sunil , Lindsay Daniel , Chen Q. Brent , Garrett Amy L. , Tan Xianming M. , Anders Carey K. , Carey Lisa A. , Gupta Gaorav P. 
Published: November 2018

AbstractSerial monitoring of plasma DNA mutations in estrogen receptor positive metastatic breast cancer (ER + MBC) holds promise as an early predictor of therapeutic response. Here, we developed dPCR-SEQ, a customized assay that utilizes digital PCR-based target enrichment followed by next-generation sequencing to analyze plasma DNA mutations in ESR1, PIK3CA, and TP53. We validated dPCR-SEQ in a prospective cohort of 58 patients with ER + MBC and demonstrate excellent concordance with hotspot ESR1 mutation abundance measured by conventional digital PCR. The dPCR-SEQ assay revealed ESR1, PIK3CA, and TP53 plasma ctDNA mutations in 55%, 32%, and 32% of the study patients, respectively. We also observed dynamic changes in ESR1, PIK3CA, and TP53 ctDNA mutant allele fraction (MAF) that were frequently discordant between the different genes. Thus, monitoring plasma DNA mutation dynamics using a dPCR-SEQ assay is feasible, accurate, and may be investigated as a biomarker of therapeutic response in ER + MBC.
Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
Authors: Okolo Frances C. , Zhang Guangfeng , Rhodes Julie , Potoka Douglas A. 
Published: November 2018

AbstractThe etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development via modulation of vSMC phenotype from undifferentiated, proliferative phenotype to differentiated, contractile phenotype. We utilized the nitrofen model of CDH to examine the effect of IA sildenafil on pulmonary vSMC phenotype during lung development. Timed-pregnant CD-1 mice were gavage fed 25 mg nitrofen or olive oil (control) at E8.5 of gestation. Single IA injections of Sildenafil (Revatio; 10 µL of 4 mg/4 ml solution) or dextrose control were performed at E12.5. Mice were sacrificed on various gestational days for embryonic lung harvest. Markers of vSMC development of undifferentiated and differentiated phenotypes were analyzed by immunostaining and western blot. Across all time points in gestation, nitrofen-treated embryonic lungs demonstrated increased vSMC expression of NOTCH3, Hes-5, PDGFR-β, desmin and α-SMA and decreased expression of calponin and SMMHC, compared to oil controls. IA dextrose treatment had no effect on expression levels. However, IA Sildenafil treatment resulted in down-regulation of NOTCH3, Hes-5, PDGFR-β, desmin and α-SMA and upregulation of calponin and SMMHC, comparable to oil controls. In the nitrofen model, vSMC express markers consistent with more undifferentiated proliferative phenotype, resulting in hypermuscularization of intrapulmonary arterioles in CDH. A single dose of IA Sildenafil treatment early in gestation, results in sustained normalization of vSMC phenotype. Pharmacologic modulation of the vSMC phenotype at key gestational points may have therapeutic potential.
Rabi splitting and optical Kerr nonlinearity of quantum dot mediated by Majorana fermions
Authors: Chen Hua-Jun , Wu Hong-Wei 
Published: November 2018

AbstractMajorana fermions (MFs), due to their significance in fundamental physics and potential applications in topological quantum computation based on solid-state devices, have drawn widespread attention. Here, we design a hybrid semiconductor/superconductor ring (S/SR) device and put forward an optical method for detecting a pair of MFs in the S/SR device with a quantum dot (QD) with the popular optical pump-probe scheme, which is very different from the present electrical method only considering one nearby MF coupled to the QD. The symmetric and unsymmetric Rabi splitting and optical Kerr nonlinear effect of QD mediated by MFs are investigated under uncoupled and coupled majorana modes, respectively. The coherent optical spectra indicate that a pair of MFs coupled to the QD induced remarkable splitting under different parameters regime and the physical origin of these phenomena are elaborated detailedly. Due to QD-MFs coupling, the probe absorption spectra present the phenomenon of Majorana modes induced transparency (MMIT) which will induce remarkable phenomena of slow light. The coherent optical spectra afford a potential supplement for probing MFs and support Majorana fermions-based topological quantum computation.
Antiaromatic character of cycloheptatriene-bis-annelated indenofluorene framework mainly originated from heptafulvene segment
Authors: Yamamoto Keitaro , Ie Yutaka , Tohnai Norimitsu , Kakiuchi Fumitoshi , Aso Yoshio 
Published: November 2018

AbstractFully π-conjugated polycyclic hydrocarbons with antiaromatic character have attracted research attention because of their unique properties such as narrow energy gaps, and thus should find application as optical and electronic materials. Although antiaromatic 16π-electron frameworks can be constructed by the incorporation of multiple seven-membered rings in a fused fashion to install methylenecycloheptatriene (heptafulvene) segments, the development of corresponding benzo[1,2:4,5]di[7]annulene (BDA)-containing π-conjugated systems remains challenging due to the difficulty of their molecular design and synthesis. In this study, we develop an unprecedented chemical structure of cycloheptatriene-bis-annelated indenofluorene, which possesses both BDA and indenofluorene frameworks in a fused fashion. Physical measurements and X-ray analyses, along with theoretical calculations, indicated that antiaromaticity appeared in the BDA framework. By using the conjugated polycyclic hydrocarbon possessing both seven-membered and five-membered rings, this study provides fundamental insight into the strong antiaromatic nature of heptafulvene-based BDA framework.
High Abundance of genus Prevotella in the gut of perinatally HIV-infected children is associated with IP-10 levels despite therapy
Authors: Kaur Urvinder S. , Shet Anita , Rajnala Niharika , Gopalan Bindu Parachalil , Moar Preeti , D Himanshu , Singh Balendra Pratap , Chaturvedi Rupesh , Tandon Ravi 
Published: November 2018

AbstractPerinatal HIV infection is characterized by faster HIV disease progression and higher initial rate of HIV replication compared to adults. While antiretroviral therapy (ART) has greatly reduced HIV replication to undetectable levels, there is persistent elevated inflammation associated with HIV disease progression. Alteration of gut microbiota is associated with increased inflammation in chronic adult HIV infection. Here, we aim to study the gut microbiome and its role in inflammation in treated and untreated HIV-infected children. Examination of fecal microbiota revealed that perinatally infected children living with HIV had significantly higher levels of genus Prevotella that persisted despite ART. These children also had higher levels of soluble CD14 (sCD14), a marker of microbial translocation, and IP-10 despite therapy. The Prevotella positively correlated with IP-10 levels in both treated and untreated HIV-infected children, while genus Prevotella and species Prevotella copri was inversely associated with CD4 count. Relative abundance of genus Prevotella and species Prevotella copri showed positive correlation with sCD14 in ART-suppressed perinatally HIV-infected children. Our study suggests that gut microbiota may serve as one of the driving forces behind the persistent inflammation in children despite ART. Reshaping of microbiota using probiotics may be recommended as an adjunctive therapy along with ART.