bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between life, security and rights: Framing the interdiction of ‘boat migrants’ in the Central Mediterranean and Australia
Authors: Moreno-Lax Violeta , Ghezelbash Daniel , Klein Natalie 
Published: September 2019

AbstractThis article sets out two case studies to examine the evolving reality of ‘boat migration’ and the intersecting legal frameworks at play. Our analysis takes a systemic integration approach to reflect on the complex dynamics underpinning responses to the phenomenon in Australia and the Central Mediterranean. The regime that governments purport to act under in any given instance reflects the way they choose to frame incidents and possibly exploit legal gaps in, or contested interpretations of, the relevant rules. The ‘closed ports’ strategy adopted by Italy and Malta against the MV Lifeline and the detention-at-sea policy pursued by Australia are investigated from the competing perspectives of what we call the ‘security lens’ and the ‘humanitarian lens’ to demonstrate how a good faith interpretation of the applicable (if apparently conflicting and overlapping) norms can (and should) be mobilized to save lives, and how that goal is unduly undercut when security concerns trump humanitarian interests.
Addiction and Voluntariness: Five “Challenges” to Address in Moving the Discussion Forward
Authors: RACINE ERIC , BARNED CLAUDIA 
Published: September 2019

Abstract:The question as to whether people with an addiction have control (and to what extent) over their addiction, and voluntarily decide to use substances is an ongoing source of controversy in the context of research on addiction, health policy and clinical practice. We describe and discuss a set of five challenges for further research into voluntariness (definition[s], measurement and study tools, first person perspectives, contextual understandings, and connections to broader frameworks) based on our own research experiences and those of others.
Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene Editing
Authors: CWIK BRYAN 
Published: September 2019

Abstract:Since the advent of recombinant DNA technology, expectations (and trepidations) about the potential for altering genes and controlling our biology at the fundamental level have been sky high. These expectations have gone largely unfulfilled. But though the dream (or nightmare) of being able to control our biology is still far off, gene editing research has made enormous strides toward potential clinical use. This paper argues that when it comes to determining permissible uses of gene editing in one important medical context—germline intervention in reproductive medicine—issues about enhancement and eugenics are, for the foreseeable future, a red herring. Current translational goals for gene editing research involve a different kind of editing than would be required to achieve manipulation of complex traits such as intelligence, and there are more pressing (and unresolved) questions that need attention if clinical use of gene editing in reproductive medicine ever becomes a possibility.
The limits of plain legal language: understanding the comprehensible style in law
Authors: Ződi Zsolt 
Published: September 2019

AbstractThe comprehensible style of legal texts seems to be a predominantly linguistic problem. This is how the plain-legal-language movements present it. But, while plain-language statutes have been on the agenda for decades in every civilised country, laws still become more and more complicated. The paper attempts to explain this controversy. First, it argues that comprehensibility has more aspects beyond the linguistic or stylistic one. Sometimes it is the linguistically simplest texts that raise the most serious comprehensibility problems. The paper refers to two pieces of corpus linguistic research that provide evidence that vocabulary and grammar in themselves do not explain the incomprehensibility of the legal texts. Second, for a more subtle handling of the comprehensibility problem, the paper offers a framework of three typical pragmatic situations – the processual, the problem-solving and the compliance settings – where comprehensibility problems arise in different ways. The conclusion of the paper is that, contrary to the usual explanation that the main reason for incomprehensibility is that, in law, clarity and accuracy can be only employed at each other's expense, it is rather the systemic and interpretive character of law and the growing importance of technical rules that hinder the understanding of legal texts.
Towards a semiotic theory of style in law: a Peircean approach
Authors: Bor Bettina , Könczöl Miklós 
Published: September 2019

AbstractThis paper discusses the promises and limits of a Peircean semiotic approach to the concept of style in law. It does so in two steps: first (1) by identifying the place of style within the structure of law as a system of signs, then (2) by conceptualising the link between law and style in the thought of C.S. Peirce and highlighting some of the insights from a Peircean take on legal semiotics that may contribute to our understanding of the role of style in making meaning in law. It is argued that, for a Peircean analysis of law, three levels can be distinguished, from the ‘surface structure’ down to the ‘deep structure’. It is at the middle level (that of the ‘basic structure’) that a semiotic approach can yield coherent insights in terms of style, by examining the symbols and metaphors that make for the expressibility of ‘habits’, namely experience-based patterns of action and interpretation.
TwinsUK: The UK Adult Twin Registry Update
Authors: Verdi Serena , Abbasian Golboo , Bowyer Ruth C. E. , Lachance Genevieve , Yarand Darioush , Christofidou Paraskevi , Mangino Massimo , Menni Cristina , Bell Jordana T. , Falchi Mario , Small Kerrin S. , Williams Frances M. K. , Hammond Christopher J. , Hart Deborah J. , Spector Timothy D. , Steves Claire J. 
Published: September 2019

AbstractTwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition, over 1800 parents and siblings of twins are registered volunteers. During the last 27 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioral, dietary and socioeconomic cohort characterization; it provides a multidisciplinary platform for the study of complex disease during the adult life course, including the process of healthy aging. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genomewide scans of single-nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community — interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK.
Estimating the Health‐Related Costs of 10 Climate‐Sensitive U.S. Events During 2012
Authors: Limaye Vijay S. , Max Wendy , Constible Juanita , Knowlton Kim 
Published: September 2019

AbstractClimate change threatens human health, but there remains a lack of evidence on the economic toll of climate‐sensitive public health impacts. We characterize human mortality and morbidity costs associated with 10 climate‐sensitive case study events spanning 11 US states in 2012: wildfires in Colorado and Washington, ozone air pollution in Nevada, extreme heat in Wisconsin, infectious disease outbreaks of tick‐borne Lyme disease in Michigan and mosquito‐borne West Nile virus in Texas, extreme weather in Ohio, impacts of Hurricane Sandy in New Jersey and New York, allergenic oak pollen in North Carolina, and harmful algal blooms on the Florida coast. Applying a consistent economic valuation approach to published studies and state estimates, we estimate total health‐related costs from 917 deaths, 20,568 hospitalizations, and 17,857 emergency department visits of $10.0 billion in 2018 dollars, with a sensitivity range of $2.7–24.6 billion. Our estimates indicate that the financial burden of deaths, hospitalizations, emergency department visits, and associated medical care is a key dimension of the overall economic impact of climate‐sensitive events. We found that mortality costs (i.e., the value of a statistical life) of $8.4 billion exceeded morbidity costs and lost wages ($1.6 billion combined). By better characterizing health damages in economic terms, this work helps to shed light on the burden climate‐sensitive events already place on U.S. public health each year. In doing so, we provide a conceptual framework for broader estimation of climate‐sensitive health‐related costs. The high health‐related costs associated with climate‐sensitive events highlight the importance of actions to mitigate climate change and adapt to its unavoidable impacts.
Role of the dorsal periaqueductal gray in posttraumatic stress disorder: mediation by dopamine and neurokinin
Authors: Brandão M. L. , Lovick T. A. 
Published: September 2019

AbstractIn susceptible individuals, exposure to intensely traumatic life events can lead to the development of posttraumatic stress disorder (PTSD), including long-term dysregulation of the contextual processing of aversive stimuli, the overgeneralization of learned fear, and impairments in the ability to learn or respond to safety signals. The neuropathophysiological changes that underlie PTSD remain incompletely understood. Attention has focused on forebrain structures associated with fear processing. Here we consider evidence from human and animal studies that long-lasting changes in functional connectivity between the midbrain periaqueductal gray (dPAG) and amygdala may be one of the precipitating events that contribute to PTSD. Long-lasting neuroplastic changes in the dPAG can persist after a single aversive stimulation and are pharmacologically labile. The early stage (at least up to 24 h post-stimulation) involves neurokinin-1 receptor-mediated events in the PAG and amygdala and is also regulated by dopamine, both of which are mainly involved in transferring ascending aversive information from the dPAG to higher brain structures, mainly the amygdala. Changes in the functional connectivity within the dPAG-amygdala circuit have been reported in PTSD patients. We suggest that further investigations of plasticity and pharmacology of the PAG-amygdala network provide a promising target for understanding pathophysiological circuitry that underlies PTSD in humans and that dopaminergic and neurokininergic drugs may have a potential for the treatment of psychiatric disorders that are associated with a dysfunctional dPAG.
Invariant and smooth limit of discrete geometry folded from bistable origami leading to multistable metasurfaces
Authors: Liu Ke , Tachi Tomohiro , Paulino Glaucio H. 
Published: September 2019

AbstractOrigami offers an avenue to program three-dimensional shapes via scale-independent and non-destructive fabrication. While such programming has focused on the geometry of a tessellation in a single transient state, here we provide a complete description of folding smooth saddle shapes from concentrically pleated squares. When the offset between square creases of the pattern is uniform, it is known as the pleated hyperbolic paraboloid (hypar) origami. Despite its popularity, much remains unknown about the mechanism that produces such aesthetic shapes. We show that the mathematical limit of the elegant shape folded from concentrically pleated squares, with either uniform or non-uniform (e.g. functionally graded, random) offsets, is invariantly a hyperbolic paraboloid. Using our theoretical model, which connects geometry to mechanics, we prove that a folded hypar origami exhibits bistability between two symmetric configurations. Further, we tessellate the hypar origami and harness its bistability to encode multi-stable metasurfaces with programmable non-Euclidean geometries.
Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
Authors: Masamsetti V. Pragathi , Low Ronnie Ren Jie , Mak Ka Sin , O’Connor Aisling , Riffkin Chris D. , Lamm Noa , Crabbe Laure , Karlseder Jan , Huang David C. S. , Hayashi Makoto T. , Cesare Anthony J. 
Published: September 2019

AbstractMitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in human cells and identify that replication stress principally induces mitotic death signalled through two independent pathways. In p53-compromised cells we find that lethal replication stress confers WAPL-dependent centromere cohesion defects that maintain spindle assembly checkpoint-dependent mitotic arrest in the same cell cycle. Mitotic arrest then drives cohesion fatigue and triggers mitotic death through a primary pathway of BAX/BAK-dependent apoptosis. Simultaneously, a secondary mitotic death pathway is engaged through non-canonical telomere deprotection, regulated by TRF2, Aurora B and ATM. Additionally, we find that suppressing mitotic death in replication stressed cells results in distinct cellular outcomes depending upon how cell death is averted. These data demonstrate how replication stress-induced mitotic catastrophe signals cell death with implications for cancer treatment and cancer genome evolution.
High-performance bifunctional polarization switch chiral metamaterials by inverse design method
Authors: Liu Chuanbao , Bai Yang , Zhou Ji , Zhao Qian , Yang Yihao , Chen Hongsheng , Qiao Lijie 
Published: September 2019

AbstractMultifunctional polarization controlling plays an important role in modern photonics, but their designs toward broad bandwidths and high efficiencies are still rather challenging. Here, by applying the inverse design method of model-based theoretical paradigm, we design cascaded chiral metamaterials for different polarization controls in oppositely propagating directions and demonstrate their broadband and high-efficiency performance theoretically and experimentally. Started with the derivation of scattering matrix towards specified polarization control, a chiral metamaterial is designed as a meta-quarter-wave plate for the forward propagating linearly polarized wave, which converts the x- or y-polarized wave into a nearly perfect left- or right-handed circularly polarized wave; intriguingly, it also serves as a 45° polarization rotator for the backward propagating linearly polarized waves. This bifunctional metamaterial shows a high transmission as well as a broad bandwidth due to the Fabry–Perot-like interference effect. Using the similar approach, an abnormal broadband meta-quarter-wave plate is achieved to convert the forward x- and y-polarized or the backward y- and x-polarized waves into left- and right-handed circularly polarized waves with high transmission efficiencies. The integration of multiple functions in a single structure endows the cascaded chiral metamaterials with great interests for the high-efficiency polarization-controlled applications.
Shear Wave Predictions of Achilles Tendon Loading during Human Walking
Authors: Keuler Emily M. , Loegering Isaac F. , Martin Jack A. , Roth Joshua D. , Thelen Darryl G. 
Published: September 2019

AbstractThe evaluation of in vivo muscle-tendon loads is fundamental to understanding the actuation of normal and pathological human walking. However, conventional techniques for measuring muscle-tendon loads in the human body are too invasive for use in gait analysis. Here, we demonstrate the use of noninvasive measures of shear wave propagation as a proxy for Achilles tendon loading during walking. Twelve healthy young adults performed isometric ankle plantarflexion on a dynamometer. Achilles tendon wave speed, tendon moment arms, tendon cross-sectional area and ankle torque were measured. We first showed that the linear relationship between tendon stress and wave speed squared can be calibrated from isometric tasks. There was no significant effect of knee angle, ankle angle or loading rate on the subject-specific calibrations. Calibrated shear wave tensiometers were used to estimate Achilles tendon loading when walking at speeds ranging from 1 to 2 m/s. Peak tendon stresses during pushoff increased from 41 to 48 MPa as walking speed was increased, and were comparable to estimates from inverse dynamics. The tensiometers also detected Achilles tendon loading of 4 to 7 MPa in late swing. Late swing tendon loading was not discernible in the inverse dynamics estimates, but did coincide with passive stretch of the gastrocnemius muscle-tendon units. This study demonstrates the capacity to use calibrated shear wave tensiometers to evaluate tendon loading in locomotor tasks. Such technology could prove beneficial for identifying the muscle actions that underlie subject-specific movement patterns.
Persian cats under first opinion veterinary care in the UK: demography, mortality and disorders
Authors: O’Neill Dan G. , Romans Charlotte , Brodbelt Dave C. , Church David B. , Černá Petra , Gunn-Moore Danièlle A. 
Published: September 2019

AbstractPersian cats are a popular cat breed worldwide, and especially in the US, Europe and Asia. This study aimed to describe the demography, common disorders and mortality in Persians under general practice veterinary care in 2013 in the UK. The study population of 285,547 cats overall included 3235 (1.1%) Persians. Mean adult Persian bodyweight was 3.9 kg (SD 0.9) and median age was 7.0 years (IQR 3.3–11.6). At least one disorder was recorded in 2099 (64.9%) Persians. The most common specific disorders were haircoat disorders (411, 12.7%), periodontal disease (365, 11.3%), overgrown nails (234, 7.2%), and ocular discharge (188, 5.8%). The most common disorder groups were dermatological (578, 17.9%), ophthalmological (496, 15.3%) and dental (397, 12.3%). Median longevity was 13.5 years (IQR 9.9–16.0). The most common grouped causes of death were renal disease (102, 23.4%), neoplasia (37, 8.5%) and mass-associated disorder (35, 8.0%). This is the first study to use general practice data to examine the overall health of Persian cats. With haircoat, ocular and dental disorders being the predominant disorders identified, this study highlights the need for increased owner awareness to manage and prevent the typical health problems associated with this breed’s phenotype.
Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age
Authors: Barbosa Marconi , Maddess Ted , Ahn Samyoul , Chan-Ling Tailoi 
Published: September 2019

AbstractWe apply novel analyses to images of superficial capillaries that are located near and around the optic disc of the human retina: the radial peri-papillary capillaries (RPCs). Due to their unique perfusion of the nerve fibre layer the RPCs are particularly significant for optic-neuropathies. The inputs to the analysis were z-stacks from 3D confocal fluorescence microscopy from 62 human retinas aged 9 to 84 years. Our aim was to find morphometric correlates of age. The retinas had no ophthalmic history. The analysis was undertaken in two stages: (1) converting the z-stacks to 3D tubular networks of vessels, and (2) characterizing the tubular networks using features derived from the Minkowski functionals (MFs). The MFs measure: the capillary volume, surface area, mean breadth, and Euler number. The mean breadth is related to tortuosity, wall shear stress and resistance to flow, and the Euler number is related to the density of loops (collaterals). Features derived from the surface area, mean breadth and Euler number were most related to age (all p ≤ 0.006). The results indicate the importance of pressure-equalizing loops and tortuosity as quantitative measures related to perfusion efficiency. The novel morphometric analysis could quantify disease-related accelerated aging and vessel malformation.
The coral Platygyra verweyi exhibits local adaptation to long-term thermal stress through host-specific physiological and enzymatic response
Authors: Wang Jih-Terng , Wang Yi-Ting , Keshavmurthy Shashank , Meng Pei-Jei , Chen Chaolun Allen 
Published: September 2019

AbstractClimate change threatens coral survival by causing coral bleaching, which occurs when the coral’s symbiotic relationship with algal symbionts (Symbiodiniaceae) breaks down. Studies on thermal adaptation focus on symbionts because they are accessible bothin vitroandin hospite. However, there is little known about the physiological and biochemical response of adult corals (without Symbiodiniaceae) to thermal stress. Here we show acclimatization and/or adaptation potential of menthol-bleached aposymbiotic coralPlatygyra verweyiin terms of respiration breakdown temperature (RBT) and malate dehydrogenase (MDH) enzyme activity in samples collected from two reef sites with contrasting temperature regimes: a site near a nuclear power plant outlet (NPP-OL, with long-term temperature perturbation) and Wanlitong (WLT) in southern Taiwan. AposymbioticP. verweyifrom the NPP-OL site had a 3.1 °C higher threshold RBT than those from WLT. In addition, MDH activity inP. verweyifrom NPP-OL showed higher thermal resistance than those from WLT by higher optimum temperatures and the activation energy required for inactivating the enzyme by heat. The MDH from NPP-OL also had two times higher residual activity than that from WLT after incubation at 50 °C for 1 h. The results of RBT and thermal properties of MDH inP. verweyidemonstrate potential physiological and enzymatic response to a long-term and regular thermal stress, independent of their Symbiodiniaceae partner.
Dynamical controls on the longevity of a non-linear vortex : The case of the Lofoten Basin Eddy
Authors: Bosse Anthony , Fer Ilker , Lilly Jonathan M. , Søiland Henrik 
Published: September 2019

AbstractThe Lofoten Basin is the largest oceanic reservoir of heat in the Nordic Seas, and the site of important heat fluxes to the atmosphere. An intense permanent anticyclone in the basin impacts the regional hydrography, energetics, and ecosystem. Repeated sampling of this Lofoten Basin Eddy from dedicated cruises, autonomous profiling gliders, and acoustically-tracked subsurface floats enables the documentation of its dynamics and energetics over the course of 15 months. The eddy core, in nearly solid-body rotation, exhibits an unusually low vertical vorticity close to the local inertial frequency and important strain rates at the periphery. Subsurface floats as deep as 800 m are trapped within the core for their entire deployment duration (up to 15 months). The potential vorticity is reduced in the core by two orders of magnitude relative to the surroundings, creating a barrier. In the winter, this barrier weakens and lateral exchanges and heat flux between the eddy and the surroundings increase, apparently the result of dynamical instabilities and a possible eddy merger. Based on a simple energy budget, the dissipation timescale for the eddy energy is three years, during which wintertime convection seasonally modulates potential and kinetic energy.