bluuebunny/crossref_metadata_2025_split huggingface dataset:
The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer
Authors: Ma Lixin , Zhai Bo , Zhu Huaqiang , Li Weidong , Jiang Wenjing , Lei Liwang , Zhang Shujun , Qiao Haiquan , Jiang Xian , Sun Xueying 
Published: September 2019

AbstractBackgroundNeuropilin-1 (NRP-1) is a non-tyrosine kinase receptor interacting with multiple signaling pathways that underpin the biological behavior and fate of cancer cells. However, in pancreatic cancer, the mechanisms underlying the function of NRP-1 in cell proliferation and metastasis and the involvement of regulatory upstream miRNAs remain unclear.MethodsPotential miRNAs were mined by using multiple bioinformatics prediction tools and validated by luciferase assays. The expression of NRP-1 and miRNA-141 (miR-141) in pancreatic tissues and cells was examined by immunohistochemistry, immunoblotting and/or real-time RT-PCR. Stable transfected cells depleted of NRP-1 were generated, and regulatory effects of miR-141 were investigated by transfecting cells with miR-141 mimics and anti-miR-141. Assays of cell viability, proliferation, cell cycle distribution, transwell migration and cell scratch were employed. Xenograft tumor models were established to assess the effects of NRP-1 depletion on tumorigenesis and liver metastasis, and therapeutic effects of miR-141 on tumor growth. The role of miR-141/NRP-1 axis in regulating epithelial–mesenchymal transition (EMT) by co-interacting the TGF-β pathway was examined.ResultsIn this study, of 12 candidate miRNAs identified, miR-141 showed the strongest ability to regulate NRP-1. In pancreatic cancer tissues and cells, the expression level of NRP-1 was negatively correlated with that of miR-141. NRP-1 was highly expressed in pancreatic cancer tissues compared with normal pancreatic tissues, and its expression levels were positively correlated with tumor grade, lymph metastasis and AJCC staging. NRP-1 depletion inhibited cell proliferation by inducing cell cycle arrest at the G0/G1 phase through upregulating p27 and downregulating cyclin E and cyclin-dependent kinase 2, and reduced cell migration by inhibiting EMT through upregulating E-cadherin and downregulating Snail and N-cadherin. Through downregulating NRP-1, miR-141 mimics showed a similar effect as NRP-1 depletion on cell proliferation and migration. NRP-1 depletion suppressed tumor growth and liver metastasis and miR-141 mimics inhibited the growth of established tumors in mice. NRP-1 depletion and/or miR-141 mimics inhibited the activation of the TGF-β pathway stimulated by TGF-β ligand.ConclusionsThe present results indicate that NRP-1 is negatively regulated by miR-141 and the miR-141/NRP-1 axis may serve as potentially valuable biomarkers and therapeutic targets for pancreatic cancer.
Structural heterogeneity in and around the fold-and-thrust belt of the Hidaka Collision zone, Hokkaido, Japan and its relationship to the aftershock activity of the 2018 Hokkaido Eastern Iburi Earthquake
Authors: Iwasaki Takaya , Tsumura Noriko , Ito Tanio , Arita Kazunori , Makoto Matsubara , Sato Hiroshi , Kurashimo Eiji , Hirata Naoshi , Abe Susumu , Noda Katsuya , Fujiwara Akira , Kikuchi Shinsuke , Suzuki Kazuko 
Published: September 2019

AbstractThe Hokkaido Eastern Iburi Earthquake (M = 6.7) occurred on Sep. 6, 2018 in the southern part of Central Hokkaido, Japan. Since Paleogene, this region has experienced the dextral oblique transpression between the Eurasia and North American (Okhotsk) Plates and the subsequent collision between the Northeast Japan Arc and the Kuril Arc due to the oblique subduction of the Pacific Plate. This earthquake occurred beneath the foreland fold-and-thrust belt of the Hidaka Collision zone developed by the collision process, and is characterized by its deep focal depth (~ 37 km) and complicated rupture process. The reanalyses of controlled source seismic data collected in the 1998–2000 Hokkaido Transect Project revealed the detailed structure beneath the fold-and-thrust belt, and its relationship with the aftershock activity of this earthquake. Our reflection processing using the CRS/MDRS stacking method imaged for the first time the lower crust and uppermost mantle structures of the Northeast Japan Arc underthrust beneath a thick (~ 5–10 km) sedimentary package of the fold-and-thrust belt. Based on the analysis of the refraction/wide-angle reflection data, the total thickness of this Northeast Japan Arc crust is only 16–22 km. The Moho is at depths of 26–28 km in the source region of the Hokkaido Eastern Iburi Earthquake. Our hypocenter determination using a 3D structure model shows that most of the aftershocks are distributed in a depth range of 7–45 km with steep geometry facing to the east. The seismic activity is quite low within the thick sediments of the fold–thrust belt, from which we find no indication on the relationship of this event with the shallow (< 10–15 km) and rather flat active faults developed in the fold-and-thrust belt. On the other hand, a number of aftershocks are distributed below the Moho. This high activity may be caused by the cold crust delaminated from the Kuril Arc side by the arc–arc collision, which prevents the thermal circulation and cools the forearc uppermost mantle to generate an environment more favorable for brittle fracture.
Deriving policies from connection codes to ensure ongoing voltage stability
Authors: Ryan David , Ponce De Leon Miguel , Grant Niall , Butler Bernard , Vogel Steffen , Mirz Markus , Lyons Pádraig 
Published: September 2019

Abstract
The management and transmission networks is becoming increasingly complex due to the proliferation of renewables-based distributed energy resources (DER). Existing control systems for DER are based on static specifications from interdependent network connection documents. Such systems are inflexible and their maintenance requires concerted effort between grid stakeholders.
In this paper we present a new supplementary control approach to increase the agility of the electricity grid. The ICT system that underlies smart grids has the potential to offer, by analogy with ICT based network management, a control plane overlay for the modern smart grid. Policy-based Network Management (PBNM) is widely deployed in managed telecoms networks. We outline how PBNM can augment the management of power and energy networks and report on our initial work to validate the approach. To configure the PBNM system, we have used text mining to derive connection parameters at the LV level. In our simulations, PBNM was used in collaboration with a Volt-VAr optimisation (VVO) to tune the connection settings at each DER to manage the voltage across all the buses. We argue that the full benefits will be realised when stakeholders focus on agreeing relatively stable high-level connection policies, the policies being refined dynamically, and algorithms such as VVO that set connection parameters so they are consistent with those high-level policies. Thus faults, power quality issues and regulatory infringement can be identified sooner, and power flow can be optimised.
Towards domain-specific surrogate models for smart grid co-simulation
Authors: Balduin Stephan , Tröschel Martin , Lehnhoff Sebastian 
Published: September 2019

Abstract
Surrogate models are used to reduce the computational effort required to simulate complex systems. The power grid can be considered as such a complex system with a large number of interdependent inputs. With artificial neural networks and deep learning, it is possible to build high-dimensional approximation models. However, a large data set is also required for the training process. This paper presents an approach to sample input data and create a deep learning surrogate model for a low voltage grid. Challenges are discussed and the model is evaluated under different conditions. The results show that the model performs well from a machine learning point of view, but has domain-specific weaknesses.
Impact of advanced electricity tariff structures on the optimal design, operation and profitability of a grid-connected PV system with energy storage
Authors: Bloch Lionel , Holweger Jordan , Ballif Christophe , Wyrsch Nicolas 
Published: September 2019

Abstract
The increasing penetration of residential photovoltaics (PV) comes with numerous challenges for distribution system operators. Technical difficulties arise when an excess of PV energy is injected into the grid, causing voltage rise or overloading of the lines. Economic challenges appear because PV owners and consumers are not participating equally in the grid costs. Indeed, PV owners benefit by self-consuming their PV production and by gaining additional revenues when they sell their PV surplus to the grid. Hence, they lower their grid costs. In this paper, we propose a mixed-integer-linear programming approach to solve the design and operation of a PV and battery system efficiently. We use this tool to benchmark five different tariff scenarios, which include real-time pricing, a capacity-based tariff, and a block rate tariff, and evaluate their effect on the design and operation of the system. Carefully tailored metrics show the impact of these tariff structures on the trade-off between the economic viability of privately owned energy systems and their grid usage intensity. Considering both aspects, we show that a block rate tariff is the most promising approach and that capacity-based tariffs rely on PV curtailment alone to curtail the generation peaks.
Model organisms at the heart of regeneration
Authors: Price Eleanor L. , Vieira Joaquim M. , Riley Paul R. 
Published: September 2019

ABSTRACT
Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a heart attack. However, many vertebrate species are capable of complete cardiac regeneration following injury. In this Review, we discuss the various model organisms of cardiac regeneration, and outline what they have taught us thus far about the cellular and molecular responses essential for optimal cardiac repair. We compare across different species, highlighting evolutionarily conserved mechanisms of regeneration and demonstrating the importance of developmental gene expression programmes, plasticity of the heart and the pathophysiological environment for the regenerative response. Additionally, we discuss how the findings from these studies have led to improvements in cardiac repair in preclinical models such as adult mice and pigs, and discuss the potential to translate these findings into therapeutic approaches for human patients following myocardial infarction.
Streptococcus pneumoniae serotype specific anti-microbial susceptibility profiles among PCV-10 vaccinated and unvaccinated children attending Gertrude’s Children’s Hospital: a cross-sectional study
Authors: Walekhwa Michael , Muturi Margaret , Kenya Eucharia , Kabera Beatrice 
Published: September 2019

Background: The spread of antimicrobial resistance threatens effective control and treatment of pneumococcal disease worldwide. In Kenya, an estimated one in every five children dies from pneumococcal disease every year. Of these, ≥50% are attributable to antibiotic resistance. Consequently, the WHO has recommended that continuous regional surveillance be done to detect early resistance to available antibiotics and make necessary changes. We therefore investigated antimicrobial susceptibility patterns of Streptococcus pneumoniae among PCV-10 vaccinated and unvaccinated children ≤5 years old at Gertrude's Children’s Hospital. Methods: A 0.5 McFarland standard of freshly subcultured organisms were inoculated on Mueller–Hinton plates with 5% sheep blood agar. A standard disk dispenser was used to dispense various antibiotic disks on the Mueller–Hinton agar plate. Incubation was done overnight (20-24 hours) at 37oC in 5% CO2 and clearance zones read using a Vanier caliber. Antimicrobials tested included vancomycin (30µg, ≥17mm); erythromycin (15µg, ≥21mm); clindamycin (2µg, ≥19mm); oxacillin (1µg, ≥19mm) and ceftriaxone (1µg, ≥30mm). Results: Thirty nine (92.86%) Streptococcus pneumoniae isolates were susceptible to erythromycin; 39 (92.86%) were susceptible to vancomycin; eight (19.86%) Streptococcus pneumoniae isolates were susceptible to oxacillin, while 34 (80.95%) were non-susceptible; 40 (95.24%) isolates were susceptible to clindamycin; and 24 (57.86%) isolates were susceptible to ceftriaxone, while 18 (42.86%) were non-susceptible. Children who attended daycare centers exhibited a four-fold significant risk of being resistant to ceftriaxone. All antibiotics studied were effective against Streptococcus pneumoniae except oxacillin and ceftriaxone, which exhibited high levels of non-susceptibility. Attendance of daycare centers, consumption of antibiotics two weeks prior to collection of sample and subject age were shown to be associated with an increased risk of Streptococcus pneumoniae being resistant to penicillins and ceftriaxone. Conclusions: The law guiding use of antibiotics in Kenya should be meritoriously enforced to curb abuse of the available antibiotics.
Group antenatal care versus standard antenatal care and effect on mean gestational age at birth in Rwanda: protocol for a cluster randomized controlled trial
Authors: Musange Sabine Furere , Butrick Elizabeth , Lundeen Tiffany , Santos Nicole , Azman Firdaus Hana , Benitez Alejandra , Nzeyimana David , Kayiramirwa Murindahabi Nathalie , Nyiraneza Lauriane , Sayinzoga Felix , Ndahindwa Vedaste , Ngabo Fidele , Condo Jeanine , Walker Dylis 
Published: September 2019

Background: Group antenatal care has demonstrated promise as a service delivery model that may result in improved outcomes compared to standard antenatal care in socio-demographic populations at disparately high risk for poor perinatal outcomes. Intrigued by results from the United States showing lower preterm birth rates among high-risk women who participate in group antenatal care, partners working together as the Preterm Birth Initiative - Rwanda designed a trial to assess the impact of group antenatal care on gestational age at birth. Methods: This study is a pair-matched cluster randomized controlled trial with four arms. Pairs randomized to group or standard care were further matched with other pairs into quadruples, within which one pair was assigned to implement basic obstetric ultrasound at the health center and early pregnancy testing at the community. At facilities randomized to group care, this will follow the opt-out model of service delivery and individual visits will always be available for those who need or prefer them. The primary outcome of interest is mean gestational age at birth among women who presented for antenatal care before 24 completed weeks of pregnancy and attended more than one antenatal care visit. Secondary outcomes of interest include attendance at antenatal and postnatal care, preterm birth rates, satisfaction of mothers and providers, and feasibility. A convenience sample of women will be recruited to participate in a longitudinal survey in which they will report such indicators as self-reported health-related behaviors and depressive symptoms. Providers will be surveyed about satisfaction and stress. Discussion: This is the largest cluster randomized controlled trial of group antenatal and postnatal care ever conducted, and the first in a low- or middle-income country to examine the effect of this model on gestational age at birth. Trial registration: This study is registered on ClinicalTrials.gov as NCT03154177 May 16, 2017.
A educação intelectual, física e moral das normalistas no Futuro das Moças
Authors: Rocha Ariza Maria 
Published: September 2019

Qual o futuro das moças em nosso país nesse meio social em que vivemos? Esta comunicação visa analisar a educação intelectual, física e moral da normalista do Rio de Janeiro veiculada no Futuro das Moças: Semanário Ilustrado (1917-1918).
PALAVRAS-CHAVE: Escola Normal. Revista Feminina. História da Educação.

ABSTRACT
What is the future of girls in our country in this society in which we live? This communication aims to analyze the intellectual, physical and moral education of normalista in Rio de Janeiro published in the Futuro das Moças: Semanário Illustrado (1917-1918).
KEYWORDS: Escola Normal. Women´s Magazine. Education of History.
Zur Homogenisierung von Testsignalen für die nichtlineare Systemidentifikation
Authors: Gringard Matthias , Kroll Andreas 
Published: September 2019

Zusammenfassung
In diesem Beitrag werden Methoden zum Entwurf von Multisinus- und Multistufensignalen zur Identifikation nichtlinearer dynamischer Takagi-Sugeno-Fuzzy-Modelle vorgestellt. Diese Entwurfsmethoden arbeiten prozessmodellfrei. Sie werden am Beispiel der Modellierung eines elektromechanischen Stellglieds eines Verbrennungsmotors demonstriert.
Dynamic Analysis of Single-Layered Graphene Nano-Ribbons (SLGNRs) with Variable Cross-Section Resting on Elastic Foundation
Authors: Jena Subrat Kumar , Chakraverty S. 
Published: September 2019

Abstract
This article deals with free vibration of the variable cross-section (non-uniform) single-layered graphene nano-ribbons (SLGNRs) resting on Winkler elastic foundation using the Differential Quadrature Method (DQM). Here characteristic width of the cross-section is varied exponentially along the length of the nano-ribbon while the thickness of the cross section is kept constant. Euler–Bernoulli beam theory in conjunction with Eringen nonlocal elasticity theory is considered in this study. The numerical as well as graphical results are reported by using MATLAB codes developed by authors. Convergence of present method is explored and our results are compared with known results available in literature showing excellent agreement. Further, effects various parameters on frequency parameters are studied comprehensively.
On the Kähler-likeness on almost Hermitian manifolds
Authors: Kawamura Masaya 
Published: September 2019

AbstractWe define a Kähler-like almost Hermitian metric. We will prove that on a compact Kähler-like almost Hermitian manifold (M2n, J, g), if it admits a positive ∂ ̄∂-closed (n − 2, n − 2)-form, then g is a quasi-Kähler metric.
Dynamic vapour sorption protocols for the quantification of accessible hydroxyl groups in wood
Authors: Uimonen Tuuli , Hautamäki Saara , Altgen Michael , Kymäläinen Maija , Rautkari Lauri 
Published: September 2019

Abstract
This study investigated several key parameters of deuterium exchange measurements in a dynamic vapour sorption apparatus to optimise the measurement protocol for hydroxyl (OH) group accessibility determination. The impact of changing the sample mass, the deuterium oxide (D2O) vapour exposure time and the rate of change in moisture content (dm dt−1) during the drying steps on the measured OH group accessibility were analysed. A sample mass of more than 10 mg, an exposure to D2O vapour of at least 10 h and a dm dt−1 of 0.0005% min−1 over a 10-min period during the drying steps gave the most reliable results. We also investigated the necessity of adding a method stage that eliminates the effect of inclusion compounds (ICs). The addition of an initial drying and wetting stage enabled the release of entrapped solvents.
Understanding the Social Structure of Academic Social Networking Sites: The Case of ResearchGate
Authors: Huang Chengsong , Zha Xianjin , Yan Yalan , Wang Yunzhi 
Published: September 2019

Abstract
The goal of ResearchGate (RG) is to help users exchange scholarly information around the world. This study drew on adaptive structuration theory (AST) to investigate the social structure of RG, which had been largely overlooked by prior research. Data were crawled from RG and results were presented based on content analysis. For the social structure embedded in RG, the most frequent updates of structural features and spirit occurred in the first two years. Six representative updates for information exchange were analyzed and the newly embedded social structures were presented. For the social structure emerging in using RG, users were more willing to answer questions than ask questions, which countered intuition. Three categories were elicited to present the purpose and expectation of questions. Users were more willing to publish publications than publish projects. Compared with reading publications and projects published by others, users seldom commented on them. For the comparison between the two social structures, this paper analyzed and compared the two social structures in terms of three types of information exchange, finding that the social structure emerging in using RG differed from that embedded in RG. We suggest that this paper could potentially help the two social structures of RG promote the optimization of each other.
Emerging rare-earth doped material platforms for quantum nanophotonics
Authors: Zhong Tian , Goldner Philippe 
Published: September 2019

Abstract
Rare-earth dopants are arguably one of the most studied optical centers in solids, with applications spanning from laser optoelectronics, biosensing, lighting to displays. Nevertheless, harnessing rare-earth dopants’ extraordinary coherence properties for quantum information technologies is a relatively new endeavor, and has been rapidly advancing in recent years. Leveraging the state-of-the-art photonic technologies, on-chip rare-earth quantum devices functioning as quantum memories, single photon sources and transducers have emerged, often with potential performances unrivaled by other solid-state quantum technologies. These existing quantum devices, however, nearly exclusively rely on macroscopic bulk materials as substrates, which may limit future scalability and functionalities of such quantum systems. Thus, the development of new platforms beyond single crystal bulk materials has become an interesting approach. In this review article, we summarize the latest progress towards nanoscale, low-dimensional rare-earth doped materials for enabling next generation rare-earth quantum devices. Different platforms with a variety of synthesis methods are surveyed. Their key metrics measured to date are presented and compared. Special attention is placed on the connection between the topology of each platform to its target device applications. Lastly, an outlook for near term prospects of these platforms are given, with a hope to spur broader interests in rare-earth doped materials as a promising candidate for quantum information technologies.
‘No One Can Serve Two Masters’: The Unity of Philosophy and Theology in Ricœur’s Early Thought
Authors: Aspray Barnabas 
Published: September 2019

Abstract
While the French philosopher Paul Ricœur is not usually thought of as an existentialist, during his early career he engaged deeply with existentialist thought, and published two articles on the relationship between existentialism and Christian faith. Ricœur’s attempts to relate philosophy and theology often led to great personal distress, which he occasionally referred to as “controlled schizophrenia,” in which he struggled to remain faithful to both philosophical and theological discourse without compromising one for the sake of the other. This essay first explores the influence of existentialist philosophy on Ricœur before surveying how Ricœur understood existentialism, and how in his view it transforms the relationship between philosophy and theology. It then shows how Ricœur is ultimately able to retain his “dual allegiance” to both discourses through active hope in how the Christian doctrine of creation ex nihilo testifies to their original and final unity.