bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zurück in die Zukunft
Authors: Köhler M. 
Published: April 2018

ZusammenfassungAdoleszente und junge Erwachsene (Adolescents and Young Adults, AYA) mit Krebs stellen mit einer Inzidenz von 15 000 Fällen pro Jahr in ihrer Peer Group eine Ausnahme dar. Mittlerweile liegen eine Reihe forschungsbasierter Befunde vor, welche die klinische Bedeutsamkeit des umschriebenen Altersintervalls zwischen dem 15. und 39. Lebensjahr im Vergleich zu Kindern und älteren Erwachsenen kennzeichnen. Darüber hinaus stehen das körperliche und seelische Erleben sowie die individuelle Bewältigung der existenziellen Abhängigkeiten durch den Krebs und die Krebsbehandlung in einem deutlichen Gegensatz zum Charakter der Lebenssituation eines gesund aufwachsenden jungen Erwachsenen. Eine Evidenz zur forschungsbasierten Entwicklung geprüfter Beurteilungsverfahren, Erhebung psychosozialer Beanspruchungen und Wirksamkeitsprüfung personalisierter Interventionsansätze ist bislang allerdings kaum gegeben. Die Anwendung entwicklungspsychologischer Konzepte und familienbasierter Ansätze kann ein professionelles Verständnis im Umgang mit den AYAKrebspatienten und deren existenziell bedrohlichen Herausforderungen fördern.
Akupunktur verringert Gelenkschmerzen
Authors: Kretzschmar Alexander 
Published: April 2018

Eine sechswöchige Akupunktur-Behandlung kann Gelenkschmerzen und -steifigkeit als Nebenwirkungen einer Therapie mit Aromatase-Inhibitoren signifikant verringern.Dies ergab eine Auswertung der SWOG 1200-Studie, die auf dem SABCS vorgestellt wurde.
The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress
Authors: Kuboyama Ayane , Sasaki Takashi , Shimizu Makoto , Inoue Jun , Sato Ryuichiro 
Published: April 2018

ABSTRACT
Transmembrane protein 100 (TMEM100) comprises 134 amino acid residues and is highly conserved among vertebrates. Tmem100 has been recently reported as a key factor in angiogenesis, pain transmission, and tumor suppression. Although the importance of TMEM100 function is well supported, few studies have elucidated its expression mechanism. In the current study, we found that activating transcription factor 6α, a transcription factor activated by endoplasmic reticulum (ER) stress, enhanced Tmem100 promoter activity. Two ER stress response element-like motifs were identified in the mouse Tmem100 promoter region. However, additional experiments using another type of ER stress inducer demonstrated that calcium signaling was more important than ER stress in the regulation of TMEM100 expression. Intracellular calcium signaling controls biological processes such as cell proliferation and embryonic development. This study suggested that TMEM100 performs various functions in response to alterations in calcium signaling in addition to those in response to ER stress.
RETRACTED: Authorship Identification for Tamil Classical Poem using Subspace Discriminant Algorithm
Authors: Pandian A , Ramalingam V V , Manikandan K , Vishnu Preet R P 
Published: April 2018

Abstract
The Development of extensive perceiving confirmation of a creator's work consolidates stylometry examination that joins various fascinating issues. Extraction of specific kind of highlights from the substance draws in us with the chance to perceive the producers of obscure works. Center of this paper is to briefly recognize the creators of unidentified Tamil dataset in context of crafted by known creators. Content preparing is the technique for getting amazing data from the dataset that joins quantifiable highlights from the dataset. This paper proposes content preparing method to concentrate features and perform grouping on the same. Crafted by a unidentified sonnet or content can be discovered in light of performing arrangement on potential creators' past known work and building a classifier to characterize the obscure lyric or content in any dialect. This procedure can be additionally reached out to every single provincial dialect around the globe. Numerous writing analysts are thinking that it’s hard to sort ballads as the writers of them are not recognized. By playing out this procedure, creators of different lyrics in Tamil vernacular can be perceived which will be significant to the general public.
RETRACTED: Survey on diagnosis of diseases from retinal images
Authors: Das Sneha , Malathy C 
Published: April 2018

Abstract
Retina is a thin membranous layer of tissue that occupies at the back of the eye which provides central vision needed for daily routines. Identifying retinal diseases at the early stage is a challenging task since healthy retina is required for central vision. Several retinal diseases affect the eye such as retinal tear, retinal detachment, glaucoma, macular hole and macular degeneration etc. These maladies will encounter a secondary growth in the close future as the age of the person increases. A survey is made which tells about the diagnosis of the retinal diseases from the retinal images using machine learning techniques.
GenomicScores: seamless access to genomewide position-specific scores from R and Bioconductor
Authors: Puigdevall Pau , Castelo Robert 
Published: April 2018

Abstract

Summary
Genomewide position-specific scores, such as those estimating conservation, constraint, fitness or mutation tolerance, are ubiquitous in current genome analyses. The diversity of sources and formats of these scores, as well as their size, increase the burden to use them. We present GenomicScores, a Bioconductor package that provides efficient storage and seamless access of genomewide position-specific scores from R, facilitating their use in genome analysis workflows.

Availability and implementation
GenomicScores is implemented in R and available at https://bioconductor.org/packages/GenomicScores under the open source ‘Artistic-2.0’ license.

Supplementary information
Supplementary data are available at Bioinformatics online.
Mice lacking all of the Skint family genes
Authors: Narita Tomoya , Nitta Takeshi , Nitta Sachiko , Okamura Tadashi , Takayanagi Hiroshi 
Published: April 2018

Abstract
γδT cells develop in the thymus and play important roles in protection against infection and tumor development, but the mechanisms by which the thymic microenvironment supports γδT cell differentiation remain largely unclear. Skint1, a B7-related protein expressed in thymic epithelial cells, was shown to be essential for the development of mouse Vγ5Vδ1 γδT cells. The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region that contains all of the Skint genes. These mice exhibited a marked reduction of Vγ5Vδ1 γδT cells in the thymus and skin, but surprisingly, had normal development of other γδT cell subsets and leukocytes including αβT, B and myeloid cells. This phenotype is essentially identical to that of Skint1-deficient mice. These results indicate that the Skint family exerts an exclusive function in regulating the development of Vγ5Vδ1 γδT cells and is dispensable for development of other leukocytes.
Antinuclear Antibodies: Marker of Diagnosis and Evolution in Autoimmune Diseases
Authors: Sur Lucia M , Floca Emanuela , Sur Daniel G , Colceriu Marius C , Samasca Gabriel , Sur Genel 
Published: April 2018

AbstractAntinuclear antibodies (ANAs) are autoantibodies that attack self-proteins within cell nucleus structures; their presence in serum may indicate an autoimmune disease. Also, positive ANA test results have been obtained in chronic infectious diseases, cancers, medication-related adverse events, and even healthy individuals. As a result, a correct interpretation of the presence of ANAs is needed.Identification of ANAs subtypes is an important part of clinical immunology. The presence of ANAs in patient blood specimens is detected using a cell-line substrate from human laryngeal carcinoma (HEp-2 cells). On this substrate, ANAs will bind specific antigens, which will lead to a suggestive fluorescent emission. The fluorescence patterns visualized under the fluorescence microscope can be correlated with certain subtypes of ANA and certain autoimmune diseases.Depending on the subtype of ANA present in the serum and the targeted antigen, several staining patterns are reported, namely, nuclear patterns, nucleolar patterns, cell cycle patterns, or cytoplasmatic patterns. Identification of a certain pattern can lead to diagnosis of a certain autoimmune disease.
Outcomes of Transvaginal High Uterosacral Ligaments Suspension: Over 500-Patient Single-Center Study
Authors: Milani Rodolfo , Frigerio Matteo , Cola Alice , Beretta Carlo , Spelzini Federico , Manodoro Stefano 
Published: April 2018

Background
Uterosacral ligament (USL) suspension is a safe and effective procedure in terms of anatomical, functional, and subjective outcomes for primary surgical treatment of prolapse.

Objectives
There has been a renewed interest toward native tissue prolapse repair by vaginal route because of low cost and lack of mesh-related complications. Uterosacral ligaments are considered safe, effective, and durable as suspending structures for primary surgical repair of the apical compartment. Our aim was to evaluate complications, anatomical, functional and subjective outcomes of high USL suspension for primary prolapse repair.

Methods
Data of patients who underwent vaginal hysterectomy followed by high USL suspension for pelvic organ prolapse were retrospectively analyzed. Operative data, as well as complications, were recorded. Anatomical recurrence was defined as descent of any compartment stage II or greater according to the Pelvic Organ Prolapse Quantification system. Functional outcomes focused on urinary, bowel, and sexual dysfunctions. International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form, Wexner, and Patient Global Impression of Improvement questionnaires were collected.

Results
Data of 533 women were analyzed. Mean follow-up was 32 (SD, 19) months (dropout rate, 2.6%). Most frequent complication was ureteral kinking (2.6%). Total recurrence rate was 13.7%, with anterior compartment being the most frequent (9.4%), whereas reoperation for symptomatic prolapse recurrence was required in only 1% of patients. Improvement of urinary incontinence, voiding dysfunction, constipation, and dyspareunia was observed. Overall subjective satisfaction was high (Patient Global Impression of Improvement score, 1.3), ranging from “much improved” to “very much improved.”

Conclusions
Uterosacral ligament suspension is a safe and effective procedure in primary surgical treatment of pelvic organ prolapse. Anatomical, functional, and subjective outcomes were very satisfactory, and reoperation rate for recurrence was only 1%.
A Fine Balance: How Authors Strategize Around Journal Submission
Authors: Ginsburg Shiphra , Lynch Meghan , Walsh Catharine M. 
Published: April 2018

Purpose
Publishing in peer-reviewed journals is essential for medical education researchers. Competition remains fierce for top journals, and authors are advised to consider impact factor (IF), audience, and alignment of focus. However, little is known about how authors balance these factors when making submission decisions. The authors aimed to explore decision making around journal choice.

Method
Using constructivist grounded theory, the authors conducted and analyzed 27 semistructured phone interviews (August–November 2016) with medical education researchers. Participants were recruited from a larger study, and all had presented abstracts at medical education meetings in 2005 or 2006.

Results
When deciding where to submit an article, participants weighed a journal’s IF and prestige against other factors, such as a journal’s vision and mission, finding the right audience, study-specific factors including perceived quality of the work, and the peer review process. The opportunity cost of aiming high and risking rejection was influenced by career stage and external pressures. Despite much higher IFs, clinical journals were viewed as less desirable for establishing legitimacy in the medical education field and were often targeted for less novel or rigorous work. Participants expressed dissatisfaction with peer review in general, citing overly critical and poorly informed reviewers.

Conclusions
Authors strategize around a particular article’s submission by attempting to balance many interrelated factors. Their perceptions that high-IF clinical journals are viewed as less prestigious in this field can lead to publication strategies running counter to advice given to junior faculty. This has implications for mentorship and institutional leadership.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE DIAGNOSIS AND FOLLOW-UP OF RETINAL ARTERIAL MACROANEURYSMS
Authors: Astroz Polina , Miere Alexandra , Cohen Salomon Yves , Querques Giuseppe , Souied Eric H. 
Published: April 2018

Purpose:
To describe optical coherence tomography angiography (OCTA) findings in retinal arterial macroaneurysm (RAM) associated with macular edema and to correlate OCTA findings with conventional multimodal imaging.

Methods:
The clinical course, conventional multimodal imaging findings including fundus color photography, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), fluorescein angiography (Heidelberg Engineering), and OCTA (Optovue, Inc, Freemont, CA) findings at baseline and during the follow-up of two eyes (two patients) with symptomatic RAM associated with macular edema were documented.

Results:
Two eyes of 2 patients, both women, aged 82 and 46 years, which presented with progressive visual decline, were included. On conventional multimodal imaging, exudative RAM with macular edema and lipid exudation were visible in both included eyes. On OCTA, the flow in the two RAM was detected at baseline. Case 1 was treated by focal laser photocoagulation. One month after treatment, fluorescein angiography showed RAM occlusion. Spectral domain optical coherence tomography showed a RAM and retinal thinning and a decreased central foveal thickness, resulting in visual acuity improvement. On OCTA, no flow was detectable in the RAM at 1-month follow-up. Case 2 was not treated at baseline. In this eye, no flow was detected on OCTA at 2-month follow-up. This suggests a spontaneous occlusion, which was confirmed by fluorescein angiography.

Conclusion:
Optical coherence tomography angiography is able to detect the presence or absence of flow signal within RAMs, which may both decrease the need for dye angiography in selected cases with exudative RAM and help in treatment decision making.
Pediatric Veno-Veno Extracorporeal Membrane Oxygenation Rescue From Carbon Monoxide Poisoning
Authors: Baran David A. , Stelling Kelly , McQueen Derrick , Pearson Mark , Shah Vaishali 
Published: April 2018

Background
Carbon monoxide poisoning affects approximately 5000 children per year and can be challenging to diagnose and treat (Pediatr Emerg Med Pract. 2016;13:1–24). It is in the differential diagnosis of a patient presented with altered consciousness. Patients may look quite “pink” and well perfused, but are often in serious distress. We present the first case in the literature of carbon monoxide poisoning treated with the use of veno-veno extracorporeal membrane oxygenation (ECMO).

Case
We report the case of a 10-year-old patient who had carbon monoxide poisoning (carboxyhemoglobin of 18%). She was treated with hydroxocobalamin at 70 mg/kg and was being prepared to transfer to a facility that offered hyperbaric therapy when she suffered a cardiac arrest requiring cardiopulmonary resuscitation. After 11 minutes of resuscitation, she had return of spontaneous circulation and an echocardiogram showed reasonable cardiac function. She was judged too unstable for ambulance transport and the ECMO team was called. Veno-veno ECMO was placed via a single right internal jugular dual-lumen catheter with fluoroscopy in the cardiac catheterization laboratory. There was a rapid improvement in carboxyhemoglobin level, and the ECMO therapy was weaned the next day. The patient eventually made a full recovery.

Conclusions
This is the first time that veno-veno ECMO has been reported for the emergent treatment of carbon monoxide intoxication. If emergency physicians are treating such a patient and cannot administer hyperbaric oxygen therapy, ECMO represents a valuable alternative that is not commonly thought of in this situation before.
Pathways From Sexual Stigma to Inconsistent Condom Use and Condom Breakage and Slippage Among MSM in Jamaica
Authors: Logie Carmen H. , Wang Ying , Marcus Natania L. , Levermore Kandasi , Jones Nicolette , Ellis Tyrone , Marshall Annecka , Newman Peter A. 
Published: April 2018

Background:
HIV prevalence among men who have sex with men (MSM) in Jamaica, where same sex practices are criminalized, is among the Caribbean's highest. Sexual stigma, the devaluation, mistreatment, and reduced power afforded to sexual minorities, is a distal driver of HIV vulnerabilities. The mechanisms accounting for associations between sexual stigma and condom use outcomes are underexplored. We examined pathways from sexual stigma to condom use and condom breakage and/or slippage among MSM in Jamaica.

Methods:
We conducted a cross-sectional survey with a chain-referral sample of MSM (n = 556) in Kingston, Montego Bay, and Ocho Rios. Structural equation modeling using weighted least squares estimation methods was conducted to test the direct effects of sexual stigma on inconsistent condom use and condom breakage/slippage, and the indirect effects through depression, sexual abuse history, and condom use self-efficacy, adjusting for sociodemographic factors.

Results:
One-fifth of participants (21%; 90/422) who had engaged in anal sex reported inconsistent condom use, and 38% (155/410) reported condom breakage/slippage during the previous 4 weeks. The relationship between sexual stigma and inconsistent condom use was mediated by the combination effect of sexual abuse history, condom use self-efficacy, and depression. The relationship between sexual stigma and condom breakage and slippage was mediated by the combination effect of condom use self-efficacy and sexual abuse history.

Conclusions:
Sexual stigma is associated with negative condom use outcomes in Jamaican MSM, mediated by psychosocial factors. Multilevel social ecological approaches to the HIV prevention cascade can inform interventions at individual, interpersonal, community, and systemic levels.
Effects of the Tailored Activity Program in Brazil (TAP-BR) for Persons With Dementia
Authors: Novelli Marcia M.P.C. , Machado Styfany C.B. , Lima Gabriela B. , Cantatore Lais , Sena Barbara P. , Rodrigues Renata S. , Rodrigues Camila I.B. , Canon Mariana B.F. , Piersol Catherine V. , Nitrini Ricardo , Yassuda Monica S. , Gitlin Laura N. 
Published: April 2018

Objectives:
The objectives of this study were to evaluate the effects of the Tailored Activity Program—Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden.

Materials and Methods:
A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care. Dyads were recruited from the community of Santos City, Brazil.

Results:
For persons with dementia, 50% were female individuals, the average age was 81.37 (±7.57), and the educational level was 9.97 (±5.32) years. For caregivers, 83.33% were female, the average age was 65.97 (±10.13), and the educational level was 12.10 (±4.44) years. At posttest, in comparison with the wait-list control group, experimental group caregivers reported greater reductions in number (P<0.001; Cohen d=0.93), frequency (P<0.001; Cohen d=1.12), and intensity (P<0.001; Cohen d=0.77) of the behavioral psychological symptoms of dementia, and caregiver distress (P<0.001; Cohen d=0.87). Caregivers also reported improvement in their own QOL (P<0.05; Cohen d=0.57) and that of the person with dementia (P<0.01; Cohen d=0.56); no differences were found in the ratings of QOL by the person with dementia themselves.

Conclusions:
The results provide compelling evidence that the TAP-BR is an effective strategy to support dementia caregivers in other cultures (cross-validation).
EquCab3, an Updated Reference Genome for the Domestic Horse
Authors: Kalbfleisch Theodore S. , Rice Edward S. , DePriest Michael S. , Walenz Brian P. , Hestand Matthew S. , Vermeesch Joris R. , O’Connell Brendan L. , Fiddes Ian T. , Vershinina Alisa O. , Petersen Jessica L. , Finno Carrie J. , Bellone Rebecca R. , McCue Molly E. , Brooks Samantha A. , Bailey Ernest , Orlando Ludovic , Green Richard E. , Miller Donald C. , Antczak Douglas F. , MacLeod James N. 
Published: April 2018

AbstractEquCab2, a high-quality reference genome for the domestic horse, was released in 2007. Since then, it has served as the foundation for nearly all genomic work done in equids. Recent advances in genomic sequencing technology and computational assembly methods have allowed scientists to improve reference assemblies of large animal and plant genomes in terms of contiguity and composition. In 2014, the equine genomics research community began a project to improve the reference sequence for the horse, building upon the solid foundation of EquCab2 and incorporating new short-read data, long-read data, and proximity ligation data. The result, EquCab3, is presented here. The count of non-N bases in the incorporated chromosomes is improved from 2.33Gb in EquCab2 to 2.41Gb from EquCab3. Contiguity has also been improved nearly 40-fold with a contig N50 of 4.5Mb and scaffold contiguity enhanced to where all but one of the 32 chromosomes is comprised of a single scaffold.
Continuous Dice Coefficient: a Method for Evaluating Probabilistic Segmentations
Authors: Shamir Reuben R , Duchin Yuval , Kim Jinyoung , Sapiro Guillermo , Harel Noam 
Published: April 2018

AbstractObjectiveOverlapping measures are often utilized to quantify the similarity between two binary regions. However, modern segmentation algorithms output a probability or confidence map with continuous values in the zero-to-one interval. Moreover, these binary overlapping measures are biased to structure’s size. Addressing these challenges is the objective of this work.MethodsWe extend the definition of the classical Dice coefficient (DC) overlap to facilitate the direct comparison of a ground truth binary image with a probabilistic map. We call the extended method continuous Dice coefficient (cDC) and show that 1) cDC ≤1 and cDC = 1 if-and-only-if the structures’ overlap is complete, and; 2) cDC is monotonically decreasing with the amount of overlap. We compare the classical DC and the cDC in a simulation of partial volume effects that incorporates segmentations of common targets for deep-brain-stimulation. Lastly, we investigate the cDC for an automatic segmentation of the subthalamic-nucleus.ResultsPartial volume effect simulation on thalamus (large structure) resulted with DC and cDC averages (SD) of 0.98 (0.006) and 0.99 (0.001), respectively. For subthalamic-nucleus (small structure) DC and cDC were 0.86 (0.025) and 0.97 (0.006), respectively. The DC and cDC for automatic STN segmentation were 0.66 and 0.80, respectively.ConclusionThe cDC is well defined for probabilistic segmentation, less biased to structure’s size and more robust to partial volume effects in comparison to DC. Significance: The proposed method facilitates a better evaluation of segmentation algorithms. As a better measurement tool, it opens the door for the development of better segmentation methods.