bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer
Authors: Muhammad Belal A. , Almozyan Sheema , Babaei-Jadidi Roya , Onyido Emenike K. , Saadeddin Anas , Kashfi Seyed Hossein , Spencer-Dene Bradley , Ilyas Mohammad , Lourdusamy Anbarasu , Behrens Axel , Nateri Abdolrahman S. 
Published: August 2018

AbstractWnt/β-catenin signaling plays a critical role during development of both normal and malignant colorectal cancer tissues. Phosphorylation of β-catenin protein alters its trafficking and function. Such conventional allosteric regulation usually involves a highly specialized set of molecular interactions, which may specifically turn on a particular cell phenotype. This study identifies a novel transcription modulator with an FLYWCH/Zn-finger DNA-binding domain, called “FLYWCH1.” Using a modified yeast-2-hybrid based Ras-Recruitment system, it is demonstrated that FLYWCH1 directly binds to unphosphorylated (nuclear) β-catenin efficiently suppressing the transcriptional activity of Wnt/β-catenin signaling that cannot be rescued by TCF4. FLYWCH1 rearranges the transcriptional activity of β-catenin/TCF4 to selectively block the expression of specific downstream genes associated with colorectal cancer cell migration and morphology, including ZEB1, EPHA4, and E-cadherin. Accordingly, overexpression of FLYWCH1 reduces cell motility and increases cell attachment. The expression of FLYWCH1 negatively correlates with the expression level of ZEB1 and EPHA4 in normal versus primary and metastatic colorectal cancer tissues in patients. Thus, FLYWCH1 antagonizes β-catenin/TCF4 signaling during cell polarity/migration in colorectal cancer.Implications:This study uncovers a new molecular mechanism by which FLYWCH1 with a possible tumor suppressive role represses β-catenin-induced ZEB1 and increases cadherin-mediated cell attachment preventing colorectal cancer metastasis.
The Utility of Feticide Procedure to Shorten the Induction-to-Abortion Interval in Medical Abortion
Authors: Akkurt Mehmet Ozgur , Akkurt Iltac , Yavuz And , Yalcin Serenat Eris , Coskun Bora , Sezik Mekin 
Published: August 2018

<b><i>Aim:</i></b> To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy. <b><i>Method:</i></b> Medically indicated abortions between 17 and 28 weeks’ gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, <i>n</i> = 58) or without an FP (group 2, <i>n</i> = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories. <b><i>Results</i></b>: There were no differences among the groups except in gestational age (GA; mean, 21.2 vs. 19.6 weeks, <i>p</i> = 0.01) in group 1. Overall, the I-to-A interval was shorter (900 ± 233 vs. 1,198 ± 375 min, <i>p</i> = 0.001) and prolonged medical abortion (I-to-A interval &#x3e; 48 h) was less common (2% vs. 6%, <i>p</i> = 0.03) in group 1. The facilitating effect of FP persisted when indications were categorized as central nervous system, chromosomal, other structural abnormalities, and unclassified conditions. Logistic regression analyses demonstrated the following features to be associated with expulsion of fetus after 24-h: (1) advanced GA (&#x3e; 24 week; aOR 6.9, 95% CI 3.24–14.72), (2) central nervous system abnormalities (aOR 5.3, 95% CI 2.6–11.4), (3) lack of feticide (aOR 3.67, 95% CI 2.24–10.72). <b><i>Conclusion:</i></b> FPs seem to shorten the I-to-A interval and decrease prolonged I-to-A interval rates. This facilitating effect remains unchanged for various medical indications.
Once-a-Day Trazodone in the Treatment of Depression in Routine Clinical Practice
Authors: Češková Eva , Šedová Michaela , Kellnerová Renata , Starobová Olga 
Published: August 2018

<b><i>Objective:</i></b> The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. <b><i>Methods:</i></b> Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores &#x3e; 21 and Clinical Global Impression – Severity (CGI/S) ≥4 were included in this post-authorization, non-interventional, observational prospective safety study, conducted in 8 psychiatric centers in the Czech ­Republic. The acute treatment phase lasted 5 weeks: 1 week of titration and 4 weeks of full-dose treatment. Patients had follow-up visits 9 and 21 weeks after commencing ­treatment. <b><i>Results:</i></b> Overall, 85 patients were enrolled in the study, of which 80 completed the acute treatment of 5 weeks. There were significant decreases in the overall MADRS score from the baseline mean value of 27.4–21.2 at week 1 (<i>p</i> &#x3c; 0.001), and a further decrease to 7.9 at week 5 (<i>p </i>&#x3c; 0.001). The severity of depression according to CGI/S gradually declined. Most patients reported improvement after 6 days of trazodone treatment. The most frequent adverse drug reactions (ADRs) reported were somnolence and fatigue. <b><i>Conclusions:</i></b> Trazodone, in the new extended-release formulation, had very good effects in clinical practice, both in previously untreated depressive episodes and in episodes not responsive to previous antidepressive therapy.
Knocking on the Door of Human-Animal Studies: Valuing Work Across Disciplinary and Species Borderlines
Authors: Hamilton Lindsay , Mitchell Laura 
Published: August 2018

AbstractWe argue that human-animal studies (HAS) literature is essential for theorizing work because it fosters a reflexive questioning of humanist power and a more sophisticated understanding of the co-dependency and co-creativity between the species. We highlight that the neglect of nonhuman animals in organization studies stems from a preoccupation with contemporary industrialization, human forms of rationality, and the mechanisms of capital exchange. Drawing upon the example of sheep and shepherding, we illustrate how a flexible approach to studying the value and worth of work is made possible by attending to other-than-human activity and value co-creation. We conclude by suggesting that the concept of work and its value needs a more species-inclusive approach to foster a less reductively anthropocentric canon of interdisciplinary scholarship in the field.
Joint Development of Offshore Oil and Gas Resources in the Arctic Ocean Region and the United Nations Convention on the Law of the Sea
Authors: Abrahamson John 
Published: August 2018

AbstractThe Arctic Ocean region presents certain challenges to peaceful cooperation between states, particularly in the locations where ocean boundaries and ownership of the related resources are disputed. The establishment of Joint Development Zones (JDZs) for the development of offshore oil and gas resources in the Arctic Ocean can facilitate international cooperation over resource development where there are competing claims. These claims are generally based on continental shelf jurisdiction under the provisions of the United Nations Convention on the Law of the Sea (UNCLOS). There are several alternative dispute resolution measures available underUNCLOS; however, a number of states have preferred to adopt aJDZas an interim measure to allow development. The significance ofJDZs for the Arctic Ocean region is that they can allow peaceful cooperation and development where the specific circumstances of Arctic claims make it difficult for the respective states to agree on the maritime boundary.
인지-인본주의적 정신 역동들 : Sidney Blatt의 이론적-철학적 업적 (Congnitive-Humanistic Psychodynamics : Sidney Blatt’s Theoretical-Philosophical Legacy)
Authors: Shahar Golan , Mayes Linda C. 
Published: August 2018

( 초록 ) 수많은 이론적-철학적 명제들이 Blatt의 광범위하고 탁월한 학문적 업적으로부터 나왔다. 그의 주요 연구 주제들은 (1) 인지, 특히 현실에 대한 마음의 지형도 혹은 표상; (2) 인본주의적인 요소들의 영향 (예컨데, 에이전시, 성장에 대한 열망, 게슈탈트, 균형 욕구 그리고 회복 탄력성); (3) 프로이트가 말한 역동적 무의식에 대한 끝없는 통찰, 이렇게 요약할 수 있을 것이다. 철학적 입장에서, Blatt은 ‘인지-인본주의적 정신역동’이라고 부를만한, 통합적 역량과 추종을 불허하는 업적들을 남겼다.
Fifteen-degree clavicular hook plate achieves better clinical outcomes in the treatment of acromioclavicular joint dislocation
Authors: Li Guanghui , Liu Tuoen , Shao Xianfang , Liu Zhijun , Duan Jianhui , Akileh Raji , Cao Shousong , Jin Dadi 
Published: August 2018

Objective Clavicular hook plate application is one of the most commonly used treatment methods for acromioclavicular (AC) joint dislocation, although it may cause multiple postoperative complications. We modified the regularly used 0° hook plate to 15° and compared the clinical outcomes of these two hook plates for treatment of AC joint dislocation. Methods Forty-three patients with acute AC joint dislocation were randomly enrolled (0° hook plate, 20 patients; 15° hook plate, 23 patients). The American Shoulder and Elbow Surgeons (ASES) and visual analog scale for pain (VASP) scores were evaluated preoperatively and at 3 days and 1, 2, 3, and 6 months postoperatively and compared between the two groups. Results Compared with the preoperative scores, the 6-month postoperative ASES score gradually increased but the VASP score decreased in both groups. Furthermore, the ASES and VASP scores were significantly different between the two groups at every postoperative time point. Conclusion The 15° hook plate is superior to the 0° hook plate in reducing shoulder pain and improving postoperative recovery in the treatment of AC joint dislocation. Level of evidence Level III; Treatment study (retrospective comparative study).
Neuronal injuries evidenced by transient cortical magnetic resonance enhancement in hemiplegic migraine: A case report
Authors: Pellerin Arnaud , Marois Clémence , Mezouar Nicolas , Mokhtari Karima , Leclercq Delphine , Law-ye Bruno 
Published: August 2018

Background Magnetic resonance imaging abnormalities in hemiplegic migraine have been described previously but were limited to a cortical thickening and biphasic alternation of hypoperfusion and hyperperfusion. Our report reveals possible blood-brain barrier disruption during migraine. Case We present the first demonstrated case of regressive diffuse hemispheric cortical enhancement in sporadic hemiplegic migraine, with histological correlation revealing neuronal lesions similar to ischemic lesions. This is probably due to the severity of the attack as indicated by the left hemiplegia and transient altered consciousness in our 43-year-old male patient. Conclusion Cortical contrast enhancement on 3D T1 images may suggest migraine severity and be predictive of neuronal loss.
Work Preferences and General Abilities Among US Pharmacy Technicians and Danish Pharmaconomists
Authors: Desselle Shane P. , Hoh Ryan , Rossing Charlotte , Holmes Erin R. , Gill Amanpreet , Zamora Lemuel 
Published: August 2018

Introduction: The importance of pharmacy support personnel is increasingly recognized. Studies have evaluated workplace issues and evolving roles; however, needed information from technicians themselves is scarce. The purpose of this study was to examine preferences for work activities and the general abilities of US pharmacy technicians and Danish pharmaconomists. Methods: Surveys were administered to random samples of US technicians in 8 states and the general population of Danish pharmaconomists. Respondents indicated their preference for involvement in a set of work activities in community or hospital pharmacy on numeric scales. They also self-assessed their level of ability on facets associated with professional practice, in general. Descriptive results were tabulated, and bivariate tests were conducted on total general abilities ratings. Results: The 494 technicians and 313 pharmaconomists provided similar ratings on many activities. In community pharmacy, US technician ratings for performance of activities were generally higher than those of pharmaconomists; however, pharmaconomists rated certain “higher order” communication activities quite highly, such as discussing lifestyle changes with the patient. In hospital practice, Danish pharmaconomists provided low preferences for medication handling but high preferences for communication activities. General ability ratings were given high self-evaluations, but lower on some components, such as keeping up with the profession. Employer commitment was a strong correlate for both. Conclusions: Evaluation of preferred work activities and general abilities were likely reflected in different scopes of practice between the two and could be insightful for education and work redesign in both countries, particularly the United States, as leaders evaluate shifts in technician professionalization.
Parent Observations of the Health Status of Infants With Clefts of the Lip: Results From Qualitative Interviews
Authors: Rosenberg Janine , Albert Meredith , Aspinall Cassandra , Bautista Suzel , Crilly Bellucci Claudia , Edwards Todd C. , Heike Carrie L. , Mecham Solange H. , Patrick Donald L. , Stueckle Laura , Kapp-Simon Kathleen 
Published: August 2018

Objective: To explore, using semistructured qualitative interviews, parent observations of their infant’s health as they relate to having a cleft lip or cleft lip and cleft palate (CL±P) and/or associated treatments. Design: Cross-sectional, qualitative study across 3 sites. Setting: Parents were recruited from 3 academic craniofacial centers. Most interviews were conducted over the telephone, audio-recorded, and transcribed. Participants: Forty-one parents (31 English-, 10 Spanish-speaking) were interviewed. Parents had a child ages 1 to 35 months diagnosed with CL±P. Main Outcome Measure(s): Twelve domains reflecting infant health and well-being, likely affected by a CL±P and/or associated treatments, were identified from clinical experience and literature review. Study investigators conducted semistructured interviews based on 12 identified domains. After transcripts of the interviews were reviewed, our multidisciplinary team selected illustrative quotes from each domain that reflected consistent observations made by parents. Results: Parents’ responses covered all 12 domains. Specifically, parents discussed the domain of feeding most frequently, followed by observations about sleep, development, comfort, breathing, and vocalization. Conclusions: We found that parents of infants with clefts provided caregiver-centered language useful in describing their daily observations. No additional domains of infant health were noted by parents. We will use these observations and language to develop and validate a parent-reported observation diary that can augment assessments of the impacts of interventions on infants who are receiving care for CL±P.
Youth perspectives on parents’ involvement in residential care in Israel
Authors: Sulimani-Aidan Yafit , Paldi Yuval 
Published: August 2018

Summary This exploratory study deals with biological parents’ involvement in residential placement in Israel from the point of view of 79 youth who left care. It presents youth’s retrospectives on their parents’ involvement in care and the degree to which the placement staff involved parents in reality. The youth functioning while in care and after leaving were also examined according to their parents’ involvement. Findings Results show that only a quarter of the youth reported that staff involved their parents on a regular basis. T-tests and chi square tests showed significant differences in functioning between young adults with high and low parental involvement. Youth whose parents were more involved had better educational achievement in care and after and reported significantly lower involvement in risky behaviors than those with lower parental involvement. However, no group differences were found regarding outcomes in adjustment to military service and financial status. Applications The findings emphasize the gaps in parental involvement in care by staff and the potential contribution of engaging biological parents in the lives of their children while in care and toward emancipation.
Liposomal Curcumin Attenuates the Incidence of Oxidative Stress, Inflammation, and DNA Damage Induced by Copper Sulfate in Rat Liver
Authors: Alhusaini Ahlam , Fadda Laila , Hassan Iman , Ali Hanaa M. , Alsaadan Njood , Aldowsari Nouf , Aldosari Azizah , Alharbi Bshayer 
Published: August 2018

Background: Copper is an essential element that is used widely in agriculture as fungicides and insecticides; for example, it is used to control schistosomiasis and as an antiseptic and germicide. Copper sulfate (CuSO4) induces multiorgan dysfunction through the stimulation of reactive oxygen species and oxidative stress. Despite the numerous pharmacological effects of curcumin (CUR), its pharmacokinetic properties are less promising. Hence, there is an urgent need for novel, effective strategies to attenuate heavy metal toxicity and consequently improve the treatment efficiency. Liposomal curcumin (L-CUR) improves the dissolution, stability, and bioavailability of treatment agents. This study compared the efficacy of CUR and L-CUR with that of desferrioxamine (DES), which is a heavy metal chelator against CuSO4 hepatotoxicity. Methods: All treatments with the aforementioned antioxidants were administered for 7 days along with CuSO4. Serum levels of alanine aminotransferase, aspartate transaminase, lactate dehydrogenase, and C-reactive protein, hepatic nitric oxide (NO), and lipid peroxides (malondialdehyde) were measured; protein expression of cyclooxygenase 2 and DNA fragmentation were evaluated. Histopathological examinations were also conducted. Results: A toxic dose of CuSO4 induced elevations in the previously measured parameters; these increases were reduced by the tested antioxidants, whereas glutathione (GSH) and superoxide dismutase (SOD) levels were decreased. Treatment with the antioxidants in question modulated these levels. Liposomal CUR has more hepatoprotective efficiency than CUR, and its efficacy was similar to that of DES. The histopathological examinations confirmed these results. Conclusions: Liposomal CUR may be useful for the prevention of CuSO4-induced liver injury. Cyclooxygenase 2 protein expression and DNA fragmentation were involved in CuSO4 toxicity and treatment.
Successful endovascular recanalization of a partially occluded basilar artery fenestration
Authors: Meinel Thomas Raphael , Pult Frauke , Gralla Jan , Arnold Marcel , Bassetti Claudio , Jung Simon 
Published: August 2018

A 76-year-old man with a history of arterial hypertension, obstructive sleep apnea, dyslipidemia, family history of cardiovascular events, prestroke and overweight presented 90 minutes after acute onset of right-sided sensorimotor hemiparesis, hemiataxia and dysarthria (National Institutes of Health Stroke Scale (NIHSS) 9/42). Magnetic resonance imaging (MRI) revealed a pontine ischemia and MR angiography showed a thrombus in the middle to distal portion of the basilar artery. Owing to the location, an occlusion of one lumen of a fenestrated basilar artery was suspected. Fearing the risk of peripheral dislocation, intravenous thrombolysis was withheld after an interdisciplinary discussion and direct endovascular thrombectomy (Solitaire stent retriever) was successfully performed by passing the stent retriever specifically through the affected lumen and between the thrombus and the vascular wall, which would normally be avoided. Angiography after complete reperfusion (Thrombolysis in Cerebral Infarction grade 3) confirmed a fenestration in the middle to distal portion of the basilar artery where the thrombus was initially located (blue and green arrow). Follow-up MRI after 24 hours showed only minimal ischemic damage in the left pontine area, and the patient was discharged home with ambulatory physiotherapy for residual minimal gait disturbance (NIHSS 0).
Use of metronomic chemotherapy in the management of a cat with abdominal haemangiosarcoma
Authors: Yee-Ka Cheng Katrina , Krockenberger Mark , Bennett Peter 
Published: August 2018

Case summary A 12-year-old entire domestic shorthair was evaluated for a 5 week history of intermittent vomiting, loss of appetite and weight loss. Abdominal ultrasound revealed a multi-lobulated heterogeneous mass adjacent to the mesenteric vessels. Cytology from fine-needle aspirates was non-diagnostic. Histopathology from a Tru-cut biopsy was consistent with haemangiosarcoma. The cat was treated with metronomic chemotherapy using oral cyclophosphamide. The cat remained clinically well and was euthanased 10 months after diagnosis owing to development of a haemoabdomen. Relevance and novel information Prognosis of feline abdominal haemangiosarcoma is generally poor and limited information on treatment is available in the veterinary literature. The use of metronomic chemotherapy with oral cyclophosphamide in this cat provided a 10 month period of good-quality life.
Influence of the Anterolateral Ligament on Knee Laxity: A Biomechanical Cadaveric Study Measuring Knee Kinematics in 6 Degrees of Freedom Using Dynamic Radiostereometric Analysis
Authors: Nielsen Emil Toft , Stentz-Olesen Kasper , de Raedt Sepp , Jørgensen Peter Bo , Sørensen Ole Gade , Kaptein Bart , Andersen Michael Skipper , Stilling Maiken 
Published: August 2018

Background: An anterior cruciate ligament (ACL) rupture often occurs during rotational trauma to the knee and may be associated with damage to extracapsular knee rotation–stabilizing structures such as the anterolateral ligament (ALL). Purpose: To investigate ex vivo knee laxity in 6 degrees of freedom with and without ALL reconstruction as a supplement to ACL reconstruction. Study Design: Controlled laboratory study. Methods: Cadaveric knees (N = 8) were analyzed using dynamic radiostereometry during a controlled pivotlike dynamic movement simulated by motorized knee flexion (0° to 60°) with 4-N·m internal rotation torque. We tested the cadaveric specimens in 5 successive ligament situations: intact, ACL lesion, ACL + ALL lesion, ACL reconstruction, and ACL + ALL reconstruction. Anatomic single-bundle reconstruction methods were used for both the ACL and the ALL, with a bone-tendon quadriceps autograft and gracilis tendon autograft, respectively. Three-dimensional kinematics and articular surface interactions were used to determine knee laxity. Results: For the entire knee flexion motion, an ACL + ALL lesion increased the mean knee laxity ( P < .005) for internal rotation (2.54°), anterior translation (1.68 mm), and varus rotation (0.53°). Augmented ALL reconstruction reduced knee laxity for anterior translation ( P = .003) and varus rotation ( P = .047) compared with ACL + ALL–deficient knees. Knees with ACL + ALL lesions had more internal rotation ( P < .001) and anterior translation ( P < .045) at knee flexion angles below 40° and 30°, respectively, compared with healthy knees. Combined ACL + ALL reconstruction did not completely restore native kinematics/laxity at flexion angles below 10° for anterior translation and below 20° for internal rotation ( P < .035). ACL + ALL reconstruction was not found to overconstrain the knee joint. Conclusion: Augmented ALL reconstruction with ACL reconstruction in a cadaveric setting reduces internal rotation, varus rotation, and anterior translation knee laxity similar to knee kinematics with intact ligaments, except at knee flexion angles between 0° and 20°. Clinical Relevance: Patients with ACL injuries can potentially achieve better results with augmented ALL reconstruction along with ACL reconstruction than with stand-alone ACL reconstruction. Furthermore, dynamic radiostereometry provides the opportunity to examine clinical patients and compare the recontructed knee with the contralateral knee in 6 degrees of freedom.