bluuebunny/crossref_metadata_2025_split huggingface dataset:
774-P: Not Carbohydrate but Sucrose Intake Is Associated with Gut Dysbiosis in Japanese Patients with Type 2 Diabetes
Authors: HASHIMOTO YOSHITAKA , HAMAGUCHI MASAHIDE , KAJI AYUMI , SAKAI RYOSUKE , INOUE RYO , KASHIWAGI SAORI , MIZUSHIMA KATSURA , UCHIYAMA KAZUHIKO , TAKAGI TOMOHISA , NAITO YUJI , FUKUI MICHIAKI 
Published: June 2019

Background: There is a close association between gut dysbiosis and type 2 diabetes (T2D). However, little is known about gut dysbiosis in Japanese patients with T2D and the association between gut dysbiosis and habitual dietary intake is also unknown.
Methods: In this cross-sectional study, 97 patients with T2D and 97 subjects without T2D matched by age and sex were selected. We obtained 16S rRNA metagenomic data from fecal samples. Habitual dietary intake of patients with T2D was evaluated by brief-type self-administered diet history questionnaire. Paired t test was used for the difference between patients with T2D and subjects without T2D. Spearman’s rank correlation coefficient was used for association between gut dysbiosis and habitual dietary intake.
Results: At the phylum level, the abundance of Actinobacteria or Firmicutes in patients with T2D was higher than that in subjects without T2D, whereas that of Bacteroidetes or Fusobacteria in patients with T2D was lower (Figure). Sucrose intake was associated with the abundance of Actinobacteria (r=0.29, p&lt;0.01) or that of Bacteroidetes (r=-0.29, p&lt;0.01), whereas carbohydrate intake was not (r=0.03, p=0.77 or r=-0.12, p=0.25, respectively).
Conclusion: The abundance of gut microbiota differs between patients with T2D and subjects without, and not carbohydrate but sucrose intake is associated with gut dysbiosis in Japanese patients with T2D.

Disclosure
Y. Hashimoto: Research Support; Self; Asahi Kasei Pharma. M. Hamaguchi: None. A. Kaji: None. R. Sakai: None. R. Inoue: None. S. Kashiwagi: None. K. Mizushima: None. K. Uchiyama: None. T. Takagi: None. Y. Naito: None. M. Fukui: Research Support; Self; Astellas Pharma Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo Company, Limited, Eli Lilly and Company, Johnson & Johnson, Kyowa Hakko Kirin Co., Ltd., Merck & Co., Inc., Mitsubishi Tanabe Pharma Corporation, Novo Nordisk Inc., Ono Pharmaceutical Co., Ltd., Sanofi, Sanwa Kagaku Kenkyusho, Takeda Pharmaceutical Company Limited. Speaker's Bureau; Self; AstraZeneca, Eli Lilly and Company, Kowa Pharmaceutical Europe Co. Ltd., Kyowa Hakko Kirin Co., Ltd., Merck & Co., Inc., Mitsubishi Tanabe Pharma Corporation, Novo Nordisk Inc., Ono Pharmaceutical Co., Ltd., Sanofi, Sanwa Kagaku Kenkyusho, Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company Limited.

Funding
Japan Society for the Promotion of Science (16675576 to Y.N.); Ministry of Agriculture, Forestry and Fisheries of Japan (16824414 to Y.N.)
777-P: Enteral Nutrition in Critically Ill Patients with Hyperglycemia: A Meta-analysis of Randomized Controlled Trials with Trial Sequential Analysis
Authors: KUMBIER MAGALI , SILVA FLAVIA MORAES , PINTO LANA C. , ALMEIDA JUSSARA , OELLEN FRANZOSI 
Published: June 2019

This systematic review with meta-analysis of randomized controlled trials (RCT) aimed to compare the effect of glycemic control-specific enteral formula specific and standard enteral formula on clinical outcomes in critically ill patients with hyperglycemia. The protocol was performed according to Cochrane Handbook and registered under PROSPERO-CRD42016036495. Databases were searched up to July 2018 using medical subject headings related to enteral nutrition, critically ill patients, hyperglycemia and RCT. The quality of studies was assessed using the six GRADE domains. Two reviewers performed all steps independently (M.C.C.K. and O.F.) and extracted the data of eligible studies through a standard form. A third researcher (F.M.S.) also settled any disagreements in all steps. Meta-analyses were performed at RevMan version 5.3 using the random effect model. The I2 test was performed to evaluate the magnitude of heterogeneity. Furthermore, we performed trial sequential analysis (TSA) of the identified studies (TSA software). In the initial search literature, 178 studies were identified and four of them were eligible. Diabetes-specific enteral formula reduced capillary glycemia (I2=62%; WMD=-25.68 mg/dL, 95% CI -47.21 to -4.17, p=0.02) in comparison to standard enteral formula. Plasma glucose, duration of mechanical ventilation, length of hospital stay, and incidence of death did not differ between groups. There was not publication bias identified. TSA meta-analysis showed a benefit trend, but it is not yet determined as the analysis points to insufficient information to confirm or refute the use of diabetes-specific enteral formula. Specific enteral formula for glycemic control reduced capillary glycemia when compared to the standard formula, but it did not have significant effect in others clinical outcomes in critically ill patients.

Disclosure
M. Kumbier: None. F.M. Silva: None. L.C. Pinto: None. J. Almeida: None. F. Oellen: None.
778-P: Positive Effects Including Prevention of Type 2 Diabetes by Making One Meal a Vegetarian Diet in Japanese—A Randomized Crossover Trial
Authors: NISHIMORI EITA , OGATA SATOSHI , NAKA MOTOJI 
Published: June 2019

Background: Increased vegetable intake has been reported to lower the risk of developing various diseases including diabetes. In Japan, it is recommended to intake 350 g of vegetables a day (about 4.5 servings), but it has not been achieved. The aim of this study was to investigate that achieving 350 g of vegetables by making one meal of three a day had positive effects including prevention of diabetes.
Methods: 38 staff of Asama General Hospital without diabetes participated in a randomized crossover trial. Participants maintained a meal recommended in Japan during this study period (control arm). In the intervention arm, a meal that can consume 350 g of vegetables in one meal as lunch was offered (vege-one diet (VOD) arm). They were randomly assigned either VOD arm or control arm for 3 months with one-week washout.
Result: The average age of participants at the start was 46 years old, BMI 24 kg/m2, HbA1c 5.7%, LDL-cholesterol 127 mg/dL. There was no significant difference in nutrition component, body composition and biomarker between the VOD arm and the control arm after 3 months. Within the VOD arm, the total energy and carbohydrates decreased, and dietary fiber increased after 3 months significantly (P &lt;0.05). In the diabetes risk group (HbA1c ≧5.6%, n = 24), the decrease of HbA1c and LDL-cholesterol were noted in the VOD arm as compared with the control arm. In the VOD arm, HbA1c significantly decreased in the diabetes risk group (P &lt;0.05). In the VOD arm, prolongation of eating time, reduction of snacking, shortening of the interval of defecation and improvement of the form of the feces were significantly shown as compared with the control arm (P &lt;0.05).
Conclusion: This study suggested that making one meal of three with vegetarian diet could contribute to positive effects including of prevention of diabetes, improvement of eating habits and defecation status.

Disclosure
E. Nishimori: None. S. Ogata: None. M. Naka: None.
779-P: Comparative Effects of Two Types of Pasta vs. White Rice on Postprandial Glucose Levels in Adults with Type 1 Diabetes
Authors: PINSKER JORDAN E. , ZAVITSANOU STAMATINA , MASSA JENNIFER S. , DESHPANDE SUNIL , CHURCH MEI MEI , ANDRE CAMILLE C. , DOYLE FRANCIS J. , MICHELSON ALICIA , CREASON JAMIE , DASSAU EYAL , EISENBERG DAVID M. 
Published: June 2019

Background: Food choices are essential to successful glycemic control in persons with diabetes.
Methods: Twelve adults with type 1 diabetes (T1D) (age 58.7±14.2 years, HbA1c 7.5±1.3%) completed an in-clinic double-blinded crossover study comparing the glycemic response to higher protein pasta (10 grams protein/serving), regular pasta (7 grams protein/serving), and white rice. All meals contained 42 grams carbohydrate, were served with homemade tomato sauce, green salad and balsamic dressing, and were repeated in random order. Linear mixed effects models assessed the 5 h postprandial glycemic response.
Results: Compared to white rice, peak glucose levels were significantly lower for higher protein pasta (-32.6 mg/dL; 95% CI -48.4, -17.2; p&lt;0.001) and for regular pasta (-43.2 mg/dL, 95% CI -58.7, -27.7; p&lt;0.001). The difference between the two types of pastas did not reach statistical significance (-11 mg/dL; 95% CI -24.1, 3.4; p=0.17). Total glucose area under the curve for the 5 h postprandial period was significantly higher for white rice compared to both pastas (p&lt;0.001) (Table 1).
Conclusions: There is a significant difference in postprandial glycemic response in persons with T1D between rice and both types of pasta when consumed in equal amounts of carbohydrate. Persons with T1D need to be aware of the relative impact of commonly consumed carbohydrates in the setting of real-life meals.

Disclosure
J.E. Pinsker: Research Support; Self; Ascensia Diabetes Care, Dexcom, Inc., Insulet Corporation, LifeScan, Inc., Roche Diabetes Care, Tandem Diabetes Care. Speaker's Bureau; Self; Tandem Diabetes Care. S. Zavitsanou: Employee; Self; Novo Nordisk A/S. J.S. Massa: None. S. Deshpande: None. M. Church: None. C.C. Andre: None. F.J. Doyle: Consultant; Self; ModeAGC. Other Relationship; Self; Insulet Corporation. A. Michelson: None. J. Creason: None. E. Dassau: Consultant; Self; Eli Lilly and Company, Insulet Corporation. Research Support; Self; Dexcom, Inc., DreaMed Diabetes, Ltd., Insulet Corporation, Roche Diabetes Care, Tandem Diabetes Care, Xeris Pharmaceuticals, Inc. Speaker's Bureau; Self; Roche Diabetes Care. Other Relationship; Self; ModAGC. D.M. Eisenberg: Advisory Panel; Self; Barilla Center for Food & Nutrition Foundation. Consultant; Self; Campus for H (Japan), Infinitus (China) Company LTD., Nutrition Development Group, LLC.

Funding
Barilla Center for Food & Nutrition Foundation
787-P: Prevalence of Metabolic Syndrome in Indian Women with Polycystic Ovarian Syndrome (PCOS) and the Correlation of Dietary Nutrient Composition and Physical Activity on Components of the PCOS—A Pilot Study
Authors: MEHTA RUCHA , VARMA HETI 
Published: June 2019

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine problem in women of reproductive age group and has been linked to infertility, insulin resistance, obesity, hypertension, dyslipidemia and diabetes.
Objective: In this pilot study we seek to study the impact of meal time habits and physical activity on the prevalence of metabolic syndrome(Met Syn) in Indian women with PCOS.
Methods: 36 women (age: 28±1.4 years, BMI: 31.7 ± 0.84 kg/m2) with a diagnosis of PCOS (NIH criteria) participated in a detailed questionnaire with dietary habits and physical activity. Anthropometric measurements and fasting blood glucose, lipid profile, HbA1c were obtained in all subjects.
Results: In this group of women with PCOS, the prevalence of Met Syn was 43% and only 2 women had lean PCOS (BMI&lt;25kg/m2). The prevalence of diabetes and impaired fasting glucose was 9% and 30% respectively. Of the components of Met Syn, all subjects had low HDL and high waist circumference, 25% had hypertension. Dietary history revealed that majority (84%) had a daily breakfast and only 16% skipped the breakfast. However, there was no difference in prevalence of metabolic abnormalities between those who had versus those who did not have breakfast. On the other hand women who were more physically active (&gt;1 hour of physical activity/day) had lower BMI, systolic blood pressure (125± 3.4 vs. 112± 5.4, p&lt;0.05 mm of Hg), a lower triglyceride level and a lower prevalence of Met Syn.
Conclusions: The prevalence of Met Syn was very high in our pilot group of relatively young Indian women with PCOS. Women with lower physical activity had a higher prevalence of metabolic abnormalities suggesting the significance of increasing physical activity to prevent Met Syn in PCOS. Larger studies are indicated to develop dietary and physical activity guidelines specific to this "ethnic" high risk Indian group to prevent future diabetes.

Disclosure
R. Mehta: Advisory Panel; Self; Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes. Speaker's Bureau; Self; Janssen Pharmaceuticals, Inc. H. Varma: None.
798-P: The Prevalence and Impact of Food Insecurity on Glycemic Control in Low-Income Latinos with Type 2 Diabetes
Authors: FLORES INA CECILIA , PORRAS FIMBRES DENISSE CRISTINA , HAW J. SONYA , MIGDAL ALEXANDRA , ROTBERG BRITT , WANG HEQIONG , GALINDO RODOLFO J. , UMPIERREZ GUILLERMO E. 
Published: June 2019

The reported prevalence of food insecurity (FI), defined as the lack of consistent access to enough food for an active, healthy life, among Latino households is twice the national average. Using the U.S. Household Food Security Survey Module, we determined the prevalence, associated factors, and impact of FI on glycemic control among Latinos attending the Emory Latino Diabetes Education Program (ELDEP), a nationally accredited bilingual education program that provides free DSME classes for Latinos with low socioeconomic status in Atlanta, Georgia.
Results: Among 711 participants, a total of 295 (41.5%) were found to have FI. At baseline, there were no differences in age (50±11 vs. 50±12 years, p=0.86), gender (63% female vs. 68% male, p=0.18), BMI (31.4 vs. 31.3 kg/m2, p=0.64), insurance status (10% vs. 13%, p=0.85), annual household income &lt;$20,000 (90% vs. 86%, p=0.40), or unemployment status (47% vs. 47%, p=0.88) between FI and non-FI patients. FI patients consumed fewer vegetables at their main meal, with 54% vs. 44% consuming &lt;1/4 of a plate, respectively; p&lt;0.03. Participants with FI had higher HbA1c (9.5±2.3% vs. 8.1±2.1%, p&lt;0.001), higher rates of Spanish illiteracy (19% vs. 11%, p=0.005), lower English literacy level (9% vs. 14%, p=0.25), and a greater history of depression (36% vs. 26%, p=0.03). Despite higher HbA1c at baseline, Latinos with FI experienced a greater reduction in HbA1c at 3 months (-2.5±2.8% vs. -1.0±2.4%, p&lt;0.06) and 6 months (-2.5±2.4% vs. -0.5±0.9%, p&lt;0.01) of follow up compared to non-FI patients.
Conclusion: FI is common among Latino patients with type 2 diabetes in Georgia. Latino patients with FI significantly improved their diabetes control with access to our culturally sensitive Spanish diabetes education program. Diabetes education programs should be culturally tailored and individualized to take into consideration literacy, language fluency and food insecurity to improve diabetes self-management.

Disclosure
I.C. Flores: None. D. Porras Fimbres: None. J. Haw: None. A. Migdal: None. B. Rotberg: Employee; Self; Insulet Corporation, Novo Nordisk A/S. H. Wang: None. R.J. Galindo: Advisory Panel; Self; Abbott, Novo Nordisk Inc., Sanofi US. Research Support; Self; Novo Nordisk Inc. G.E. Umpierrez: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Janssen Pharmaceuticals, Inc. Research Support; Self; AstraZeneca, Merck & Co., Inc., Novo Nordisk Inc., Sanofi US.

Funding
Sanofi
799-P: Vascular Structure and Functional Responses to Consecutive High-Fat Feeding between Insulin Treatment Regimens in Adults with Type 1 Diabetes and Matched Controls
Authors: O'MAHONEY LAUREN L. , STAVROPOULOS ANTONIS , BIRCH KAREN , AJJAN RAMZI , PRICE OLIVER J. , CAMPBELL MATTHEW 
Published: June 2019

Background: Impaired vascular health is prevalent in type 1 diabetes (T1D); however, it remains unknown whether different insulin treatment regimens mediate indices of vascular structure or function.
Methods: Sixteen individuals with T1D receiving either multiple daily injection therapy (MDI; n=8; age: 32±13years; BMI:26.0±5.9kg.m2; HbA1c:53.7±11.2mmol/mol [7.1±3.2%]) or continuous subcutaneous insulin infusion (CSII; n=8; age:35±18years; BMI:26.3±4.6kg.m2; HbA1c: 58.6±9.7mmol/mol [7.5±3.0%]) and ten matched controls (CON; age:31±13years; BMI: 24.3±2.9kg.m2) consumed two high fat (HF) meals at 4-hour intervals. Carotid artery intima-media thickness (CIMT) and flow mediated dilation (FMD) was assessed at baseline, with further FMD assessment at 3-hours following the ingestion of each meal using high resolution B-mode ultrasound. Bolus insulin dose was standardized using the carbohydrate-counting method.
Results: CIMT was significantly higher in individuals with T1D compared to controls (p=0.039); treatment stratification within T1D revealed MDI mediated this effect (MDI vs. CON: p=0.049; CSII vs. CON: p=0.112). FMD remained unchanged following the first meal (p=0.204) but was significantly impaired following the second meal (p=&lt;0.001); post hoc analysis revealed MDI mediated this effect of impaired FMD after the second meal (MDI vs. CON: p=0.048; CSII vs. CON: p=0.416).
Conclusions: Our findings indicate that patients treated with MDI therapy have higher CIMT (a structural marker of subclinical atherosclerosis) compared to controls but not CSII therapy. FMD was impaired following a second HF meal irrespective of a diabetes status. Considering the pre-existing heightened cardiovascular disease risk in T1D therapeutic strategies to reduce postprandial risk warrants further research.

Disclosure
L.L. O'Mahoney: None. A. Stavropoulos: None. K. Birch: None. R. Ajjan: Consultant; Self; Abbott. Research Support; Self; Abbott, LifeScan, Inc. O.J. Price: None. M. Campbell: None.
802-P: Text Messaging as a Behavioral Intervention Component for Adolescents and Young Adults with T1D
Authors: MONAGHAN MAUREEN , WONG CONNIE , STREISAND RANDI 
Published: June 2019

PREP-DC (Planning, Reflecting, and Engaging with Providers for Diabetes Care) is a multicomponent behavioral intervention aimed at promoting optimal health communication between adolescents and young adults (AYAs) with T1D and health care providers (HCPs). In the PREP-DC pilot, we examined engagement with text messaging and utilized AYA feedback to revise text messages for a randomized trial. AYAs with T1D&gt;1 year (n=16; M age=18.8 years; 50% male; 44% Caucasian) participated in the pilot, consisting of 2 intervention sessions and 3 related text messages/week delivered between 2 T1D medical visits (∼16 weeks). The study team and an AYA stakeholder created a library of 72 text messages to reinforce T1D communication skills and self-care. Texts were sent via secure messaging platform. HCPs rated AYA communication at baseline and follow-up medical visits (∼16 weeks post-baseline) using the Independent Behaviors during Consultation Scale (IBDCS). A1c was taken from the medical chart. Participants received a mean of 45 texts. One text/week posed a question and encouraged AYA response (M=15.5 texts); 69% responded ≥1 text (M responses=4±4.2 texts). Intervention outcomes differed by text response. AYAs with no responses had worsening A1c (10.4% to 11.2%; p&lt;.05) and stable HCP-rated communication (IBDCS; 20.8 to 20.0; p=ns) from baseline to follow-up. AYAs with ≥ 1 response had stable A1c (9.6% to 9.6%; p=ns) and improved HCP-rated communication (IBDCS; 19.6 to 24.9; p&lt;.01) from baseline to follow-up. AYAs reported high satisfaction with text messages. Feedback was used to revise text messages, including new response prompts, graphic content (e.g., memes), and more message tailoring. Text messaging was a promising component of this intervention pilot, and an indicator of text message engagement was related to intervention response. Future studies should further examine engagement with text messages, including analytics on opening texts and message content associated with higher AYA response.

Disclosure
M. Monaghan: Research Support; Self; American Diabetes Association. C. Wong: None. R. Streisand: None.

Funding
American Diabetes Association/Pathway to Stop Diabetes (1-18-ACE-27 to M.M.); Children's National
809-P: Comparison of the Acceptability and Psychometric Properties of Scales Assessing the Impact of Type 1 Diabetes on Quality of Life: Results of the Your SAY: QoL Study
Authors: SPEIGHT JANE , HOLMES-TRUSCOTT ELIZABETH , HENDRIECKX CHRISTEL , COATES ELIZABETH , HELLER SIMON R. , COOKE DEBBIE 
Published: June 2019

Aims: To compare the acceptability, reliability and validity of five contemporary diabetes-specific quality of life (QoL) scales.
Methods: Adults with type 1 diabetes in the UK (N=1139) and Australia (N=439) completed a cross-sectional, online survey including: ADDQoL, DCP, DIDP, DSQoLS and QoL-Q diabetes (scales randomised to control for order effects). Participants rated each scale for clarity, relevance, ease of completion, length, and comprehensiveness. Scales were compared in terms of acceptability, response patterns, structure, reliability and validity. To assess cross-country reproducibility, analyses conducted on the UK sample were replicated in the Australian sample.
Results: Findings (summarized in Table 1) were largely consistent between countries. The strongest scale overall was the DIDP, a brief (7-item), neutrally-worded scale with balanced response options. ADDQoL and QoL-Q diabetes also performed well across most criteria.
Conclusions: This is the first empirical study to compare the user acceptability and psychometric properties of five contemporary diabetes-specific QoL scales. These findings may inform assessment of diabetes-specific QoL in routine care and clinical trials, but should be considered in the context of published evidence of the development and responsiveness of the scales.

Disclosure
J. Speight: Research Support; Self; AstraZeneca, Medtronic, Sanofi. Speaker's Bureau; Self; Novo Nordisk A/S, Roche Diabetes Care. E. Holmes-Truscott: Research Support; Self; Sanofi. Speaker's Bureau; Self; Novo Nordisk Inc. C. Hendrieckx: None. E. Coates: None. S.R. Heller: Advisory Panel; Self; Eli Lilly and Company, Novo Nordisk A/S, Sanofi-Aventis, Takeda Pharmaceutical Company Limited, Zealand Pharma A/S. Consultant; Self; Novo Nordisk A/S. Speaker's Bureau; Self; Eli Lilly and Company, Novo Nordisk A/S. D. Cooke: None.

Funding
UK National Institute for Health Research (RP-PG-0514-20013 to S.R.H.)