bluuebunny/crossref_metadata_2025_split huggingface dataset:
E'jiao and Cubilose Formula Induced Antioxidant Activity and Improved Collagen Expression of Human Skin Fibroblasts During Oxidation Damage
Authors: Tie Hang , Xie Xiao , Zhang Zichen , Zhang Jianling , Xu Liang , Ruan Haihua , Wu Tao , Zhang Hongyang 
Published: November 2024

ABSTRACTBackgroundAs traditional Chinese medicinal materials, E'jiao and cubilose are rich in various bioactive substances with good antioxidant, anti‐inflammatory, and immune‐regulating effects.AimTo obtain the optimal ratio of synergistic effect between E'jiao and cubilose.MethodsThe antioxidant capacity of E'jiao and cubilose digestive fluid was evaluated in vitro, as well as the intracellular oxidation balance between HSF cells and 3D whole‐skin model induced by H2O2.ResultsE'jiao, cubilose, and their different ratios of composites had better scavenging ability against free radicals such as DPPH (2,2‐Diphenyl‐1‐picrylhydrazyl). Using HSF cells induced by H2O2 as an oxidative damage model, it was found that the combination of E'jiao and cubilose in a ratio of 2:3 significantly enhanced the activities of SOD, GSH‐PX, and CAT enzymes compared to the separate treatments of E'jiao and cubilose, as well as other combination ratios. It effectively reduced the accumulation of reactive oxygen species caused by H2O2 in HSF (Human Skin Fibroblast) cells and protected the integrity of the cells. Further analysis using flow cytometry and a 3D full‐thickness skin model revealed that the combination ratio of 2:3 increased the proportion of H2O2‐treated cells in the S%+G2% phase from 19.1% + 7.4%–22.1% + 28.8%, helping oxidatively damaged cells partially recover their proliferative capacity. It also promoted the expression of collagen I and collagen IV in the 3D full‐thickness skin model, with improvement rates reaching 168.00% and 123.68%, respectively.ConclusionsThese findings indicate that the combination of E'jiao and cubilose in a ratio of 2:3 exhibits good synergistic effects, enhancing the ability of cells to resist oxidative damage, promoting cellular renewal and metabolism, and improving skin antiwrinkle capacity.
Identifying the Needs of Paediatric‐Friendly Care in Emergency Department: A Delphi Study
Authors: Chen Yen‐Ju , Tseng Wei‐Chieh , Liang Jao‐Shwann , Tung Tzu‐Hui , Cheng Su‐Fen , Chen Chi‐Wen 
Published: November 2024

ABSTRACTAimsTo systematically analyse expert perspectives on paediatric‐friendly care in the emergency department and establish specific indicators.BackgroundWith an increasing number of children seeking emergency care, nurses must understand the specific needs of paediatric patients and their families.DesignA two‐round modified Delphi method was used in this study.MethodsIn this study, experts from clinical practice and academia assessed 56 paediatric‐friendly care criteria in the emergency department. Data were collected to establish a consensus and ensure content validity.ResultsThirty experts completed two survey rounds with response rates of 100% and 93.3%, respectively. In the initial survey, no consensus was reached for eight items. After the items were consolidated, 37 paediatric emergency‐friendly care needs were identified. For each need, the item‐level content validity index exceeded 0.79 for importance and feasibility. The average scale‐level content validity index values were 0.95 and 0.92 for importance and feasibility. These needs were categorised into six dimensions: timely comfort (3 items), emotional care (5 items), frontline safety (11 items), emergency response (10 items), human resources support (5 items) and treatment efficiency (3 items).ConclusionPaediatric emergency nurses play a vital role in caring for children, improving soft skills through compassion and training and ensuring a well‐equipped, safe environment in the emergency department.Relevance of Clinical PracticeThis study offers valuable insights for emergency department nurses on the needs of children and their families, emphasising the importance of patient and family education, environmental considerations and the role of certified child life specialists in supporting the emergency healthcare team and ensuring appropriate paediatric care.Patient/Public ContributionNo direct patient, service user, caregiver or public involvement existed in this study.
Possible rapid reduction of anti‐RBD antibody titre after SARS‐CoV‐2 mRNA vaccination in pregnant women: Multicentre prospective study
Authors: Ohta Mamiko , Kawasaki Kaoru , Yamamoto Rumiko , Ishii Keisuke , Nakano Kazutoshi , Akada Shinobu , Doh Kunihiko , Shimaoka Masao , Ota Hiroshi , Moriuchi Kaori , Shiro Reona , Yo Yoshie , Yoshida Koichiro , Tohda Yuji , Matsumura Noriomi 
Published: November 2024

AbstractAimPregnant women are at increased risk for severe illness associated with coronavirus disease 2019 (COVID‐19) compared to nonpregnant women. The aim of this multicenter prospective study was to assess the current COVID‐19 vaccination status of pregnant women in the southern Osaka district and to compare their antibody titers with those of nonpregnant women.MethodsSerum antibody titers of anti‐NCP antibodies (antibodies against the SARS‐CoV‐2 nucleocapsid) and anti‐RBD antibodies (the receptor binding domain of the S1 subunit of the spike protein) were evaluated in 753 pregnant women at 34–35 weeks of gestation from October 2021 to March 2022. Anti‐RBD antibody titre was also investigated in 1003 health care workers at Kindai University hospital 3 and 6 months after a second dose of the vaccine from March 2021 to April 2021. 519 (68.9%) pregnant women were vaccinated during pregnancy, of whom 497 (95.8%) received two doses.ResultsThe COVID‐19 infection rate calculated from the number of pregnant women with a positive anti‐NCP antibody titre or with confirmed diagnosis was 5.1% (12/234) in the unvaccinated and 3.5% (18/519) in the vaccinated. The estimated half‐life calculated from anti‐RBD antibody titers and the number of days between vaccination and antibody testing was 39.9 days. The antibody titre and half‐life in pregnant women were significantly lower and shorter than in nonpregnant women aged 20–39 years (109.4 days).ConclusionOur study showed that pregnant women may have lower vaccine‐acquired COVID‐19 immunity than nonpregnant women.
Influence of the color of 3D‐printed scan aids on the trueness of complete arch digital scans
Authors: Önöral Özay , Çakır Selin 
Published: November 2024

AbstractPurposeTo determine the influence of using 3D‐printed scan aids in varying colors on the trueness of digital scans.Materials and MethodsA master cast with five multi‐unit analogues was scanned. The acquired dataset was exported to standard tessellation language (STL) file format to serve as the reference STL. 3D printing of the prototype in five distinct colors (beige [SABEIGE], grey [SAGREY], white [SAWHITE], red [SARED], and blue [SABLUE]) of polylactic acid filament was executed. The experimental STLs of each color group were aligned to the reference STL. RMS values were solely computed for the scan bodies. Based on the centers of the created best‐fit and offset planes, scan bodies were converted into virtual cylinders. Cartesian coordinates of each cylinder were acquired. Subsequently, angular (AD) and linear deviation (LD) values were calculated. LD was further examined separately along the x, y, and z axes. Data were statistically analyzed.ResultsAccording to the results of one‐way ANOVAs, significant differences were detected among color groups on AD, LD, RMS estimate error, ∆x, ∆y, and ∆z data. The lowest AD and LD values were exhibited by the SAGREY group in all implant sites. The SAGREY group was followed by the SABEIGE, SAWHITE, SARED, and SABLUE groups.ConclusionsThe SAGREY outperformed the other groups in terms of trueness. Although the LD values of all color groups were below the threshold value (<100 µm), only the AD values of the SAGREY, SABEIGE, and SAWHITE groups were clinically acceptable (<0.5°).
Pterygoid implant‐based maxillary full‐arch rehabilitation using an autonomous robot system: A case report
Authors: Lv Haoxin , Wu Hongzhao , Hu Liqun , Song Wenjuan , Gao Yutong , Zhao Mingyu , Mao Yuwei , Xia Shici , Sa Yue 
Published: November 2024

AbstractPterygoid implant placement has been proven to be a viable option in full‐arch implant rehabilitation for extremely atrophic maxillae. Nevertheless, the utilization of pterygoid implants remains a challenge for the dentist due to the difficulties of accessing the surgical site and poor visibility. To address these difficulties, digital techniques have been used to enhance the accuracy of pterygoid implant placement. This clinical case describes the application of an autonomous robot system to enhance the precision and efficacy of pterygoid implant placement. The results demonstrated that the integration of automation and real‐time imaging provided by the robot system significantly improved the safety and accuracy of the surgical procedure.
Making Decisions When Outcomes are Irreducible: Shackle's Imagination and Virtual Reality
Authors: Adra Samer 
Published: November 2024

ABSTRACTThis paper addresses the challenge of navigating irreducible outcomes, where predicting future patterns proves futile despite understanding the underlying rules. It advocates for G.L.S. Shackle's imagination‐focused decision approach as a partial solution. Integrating the concept of the extended mind, I argue that modern technological advances such as Virtual Reality (VR) further enhance Shackle's approach, rather than compromising its subjective nature. In light of the challenges in applying reductivist tools to the outcomes of VR, I propose Shackle's framework as a promising framework for integrating such outcomes into decision‐making processes. Via this framework, decision‐makers capitalize on large` gains and hedge against large losses, despite not fully overcoming irreducibility.
Collaborative control framework at isolated signalized intersections under the mixed connected automated vehicles environment
Authors: Liu Chao , Jia Hongfei , Wang Guanfeng , Wu Ruiyi , Tian Jingjing , Gao Heyao 
Published: November 2024

AbstractThis study proposes a collaborative control framework under the mixed traffic environment of connected and automated vehicles and connected human‐driven vehicles, which can simultaneously optimize the signal timing, lane settings, and vehicle trajectories at isolated intersections. Initially, considering the dynamics of traffic demand and incompatible signals, we analyze the vehicle delay of each lane. Based on the delay analysis, the spatiotemporal resource collaborative optimization model of lane setting and signal timing is established to minimize the average delay. Subsequently, in the buffer zone, a graph‐theoretic‐based sorting and platooning model provides a clear and concise representation of the transformation process from the initial state to the target state of vehicles, enabling the platoon formation. Additionally, trajectory optimization is integrated into the collaborative control framework by the optimal control model and car‐following model in the passing zone. Simulation experiments and sensitivity analyses demonstrate the effectiveness of the proposed framework in reducing average vehicle delay, improving fuel consumption, and coping with changing traffic demand at intersections.
Converging Roles of the Metal Transporter SMF11 and the Ferric Reductase FRE1 in Iron Homeostasis of Candida albicans
Authors: Patel Naisargi K. , David Marika S. , Yang Shuyi , Garg Ritu , Zhao Hongyu , Cormack Brendan P. , Culotta Valeria C. 
Published: November 2024

ABSTRACTPathogenic fungi must appropriately sense the host availability of essential metals such as Fe. In Candida albicans and other yeasts, sensing of Fe involves mitochondrial Fe‐S clusters. Yeast mutants for Fe‐S cluster assembly sense Fe limitation even when Fe is abundant and hyperaccumulate Fe. We observe this same disrupted Fe sensing with C. albicans mutants of SMF11, a NRAMP transporter of divalent metals. Mutants of smf11 hyperaccumulate both Mn and Fe and the elevated Mn is secondary to Fe overload. As with Fe‐S biogenesis mutants, smf11∆/∆ mutants show upregulation of ferric reductases that are normally repressed under high Fe, and Fe import is activated. However, unlike Fe‐S biogenesis mutants, smf11∆/∆ mutants show no defects in mitochondrial Fe‐S enzymes. Intriguingly, this exact condition of disrupted Fe sensing without inhibiting Fe‐S clusters occurs with C. albicans fre1∆/∆ mutants encoding a ferric reductase. Mutants of fre1 and smf11 display similar perturbations in the cell wall, in filamentation and in the ROS burst of morphogenesis, a Fe‐dependent process. As with FRE1, SMF11 is important for virulence in a mouse model for disseminated candidiasis. We propose a model in which FRE1 and SMF11 operate outside the mitochondrial Fe‐S pathway to donate ferrous Fe for Fe sensing.
From modality to millianism
Authors: Salmón Nathan 
Published: November 2024

AbstractA new argument is offered which proceeds through epistemic possibility (for all S knows, p), cutting a trail from modality to Millianism, the controversial thesis that the semantic content of a proper name is simply its bearer. New definitions are provided for various epistemic modal notions. A surprising theorem about epistemic necessity is proved. A proposition p can be epistemically necessary for a knowing subject S even though p is a posteriori and S does not know p. The identity relation is well‐behaved in metaphysically possible worlds but can go rogue in epistemically possible worlds. Whereas it can be epistemically possible that Lewis Carroll is not Charles Lutwidge Dodgson, this is not epistemically possible in the manner that anti‐Millianism requires.
A consumer‐oriented approach to define breeding targets for molecular breeding
Authors: Ferrão Luis Felipe V. , Azevedo Camila F. , Sims Charles A. , Munoz Patricio R. 
Published: November 2024

Summary
Flavor is a crucial aspect of the eating experience, reflecting evolving consumer preferences for fruits with enhanced quality. Modern fruit breeding programs prioritize improving quality traits aligned with consumer tastes. However, defining fruit‐quality attributes that significantly impact consumer preference is a current challenge faced by the industry and breeders.
This study proposes a data‐driven approach to statistically model the relationship between fruit‐quality parameters and consumers' overall liking. Our primary hypothesis suggests that the interplay between fruit‐quality attributes and consumer preferences may reach a critical value, serving as new empirical benchmarks for fruit quality.
Using extensive historical datasets accounting for sensory, biochemical, and genomic information described in blueberry, we first demonstrated that multivariate adaptive regression splines (MARS) could be used to identify specific values of fruit‐quality traits that significantly affect consumer perception by using nonlinear spline regressions on estimating threshold points. We harnessed genomic information and carried out genomic selection (GS) for five fruit‐quality traits evaluated on the original scale and after classified via the MARS approach.
This study provides a pioneering consumer‐centric and data‐driven approach to defining fruit‐quality standards and supporting molecular breeding that has broad applications to breeding programs from any species.
Novel Algorithm for Surgical Management of Cervical Ossification of Posterior Longitudinal Ligament: A Retrospective Cohort Study With 2‐Year Follow‐Up
Authors: Cai Zhuyun , Kang Hui , Quan Lei , Ren Yilong , Fang Meng , Tan Yixuan , Zhang Haochen , Zhou Xuhui , Ma Jun 
Published: November 2024

ABSTRACTObjectWith the development of new technologies, the surgical algorithm for ossification of posterior longitudinal ligament (OPLL) in the cervical spine also needs to be updated. The aim of this study is to elucidate a new surgical classification algorithm to guide the choice of surgical approaches for cervical OPLL based on its location and extent. In this algorithm, anterior controllable antedisplacement and fusion (ACAF) will be used as a new surgical option.MethodsThis is a single‐centered, retrospective, cohort study utilizing a novel algorithm based on the following three criteria: (1) the positional relationship between ossification and uncinate process (UP), (2) the K‐line, and (3) the ossification segment for surgical decision‐making. Patients diagnosed with cervical OPLL who received surgical intervention guided by the algorithm were included. Patient demographics, Japanese Orthopedic Association (JOA) scores, surgical time, imaging data before and 2 years after surgery, and the occurrence of complications were extracted from the database. Paired t‐test was used for intragroup comparison, and one‐way ANOVA test was used for the intergroup analyses.ResultsBased on this novel algorithm, 15 patients with Type I, 8 patients with Type II a, 2 patients with Type II b1, 5 patients with Type II b2 were included. The decision‐making for the surgical techniques used in each patient followed the recommendation of the novel algorithm. The postoperative JOA scores of all types of patients improved significantly (p < 0.05), and the invasion rates of vertebral canal had also been significantly reduced (p < 0.05). In terms of restoring cervical curvature, patients with Type I (receiving ACAF) and Type II b2 (receiving laminectomy with instrumented fusion) benefited more from surgery (p < 0.05).ConclusionA new algorithm guiding the choice of surgical approach for cervical OPLL was validated in a series of 30 patients. Through this analysis, we obtained on their clinical outcomes and complications. ACAF surgery is an ideal choice for Type I patients, with ossification located between UPs, while for patients with ossification exceeding UPs, it is better to perform anterior cervical corpectomy and fusion or posterior surgery.
Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications
Authors: Morehead Lauren C. , Duffy Emily K. , Boos Markus D. 
Published: November 2024

ABSTRACTExtended essays or commentaries providing an opportunity to express personal views and opinions that are meant to enlighten, entertain, and educate readers, and can include articles about medical history, ethics, literature or the arts related to pediatric dermatology. Patient perspectives are also encouraged. Questions on whether a potential submission is appropriate for this section can be addressed to the Editors‐in‐Chief, or the Section Editors, Lucinda Kohn, MD, MHS (lucinda.kohn@cuanschutz.edu) or Neil Prose, MD (prose001@mc.duke.edu).
Genome‐wide association study for powdery mildew resistance in CIMMYT's spring wheat germplasm
Authors: Bhadana Deepa , Kaur Prabhjot , Kaur Ramandeep , Ravat Vikas Kumar , Ashutosh  , Kumar Rahul , Vasistha Neeraj Kumar 
Published: November 2024

AbstractPowdery mildew (PM), caused by Blumeria graminis f. sp. tritici (Bgt), is a foliar disease of wheat (Triticum aestivum) that adversely affects both grain yield and quality. Growing resistant cultivars offers an effective and environmentally sustainable solution to managing PM. However, relying on the same genetic source of resistance can lead to resistance breakdown as Bgt isolates rapidly evolve. To mitigate this, identifying novel resistance sources is crucial. In this study, 225 diverse wheat genotypes were evaluated at adult plant stage in disease nurseries over the three crop seasons (2018/2019, 2019/2020 and 2020/2021). Using disease and genotyping data from 12,160 single‐nucleotide polymorphism (SNP) markers, a genome‐wide association study (GWAS) was conducted to identify novel resistance loci. We identified 22 marker loci significantly (at p < 0.005) associated with PM resistance, distributed across 14 wheat chromosomes (1A, 1B, 1D, 2A, 2B, 2D, 3A, 3B, 4A, 4B, 5D, 6A, 7A and 7B). Of these, seven loci overlap with previously identified regions, while the remaining 15 loci represent novel regions reported for the first time in this study. The identified SNP markers have significant potential for wheat breeding programmes, as they can accelerate the development of PM‐resistant cultivars through marker‐assisted selection.
Melatonin application enhances salt stress‐induced decreases in minerals, betalains, and phenolic acids in beet (Beta vulgaris L.) cultivars
Authors: Colak Nesrin , Slatnar Ana , Medic Aljaz , Torun Hülya , Kurt‐Celebi Aynur , Dräger Gerald , Djahandideh Jasmin , Esatbeyoglu Tuba , Ayaz Faik Ahmet 
Published: November 2024

AbstractMelatonin is a potentially active signaling molecule and plays a crucial role in regulating the growth and development of plants under stress conditions, alleviating oxidative damage, enhancing antioxidant defence mechanisms and regulating ion homeostasis. This study examined the effects of exogenous melatonin application on leaf biomass, ion concentrations, betalains, phenolic acid and endogenous melatonin contents comparing red beet (Beta vulgaris L. ‘Ruby Queen’ and ‘Scarlet Supreme’) and white beet (‘Rodeo’ and ‘Ansa’) cultivars under increasing salinity levels of 50, 150, and 250 mM NaCl. Exogenous melatonin increased salinity‐induced reductions in fresh and dry weights and osmotic potential in leaves. Na+ concentrations rose significantly with increasing salinity, but cultivar‐specific decreases were observed in K+ and Ca2+ concentrations. Additionally, melatonin application improved betalain, betanin and neobetanin contents induced by salt stress. Furthermore, melatonin application caused salt stress and cultivar‐specific changes in phenolic acid contents e.g., ferulic acid, sinapic acid, or m‐coumaric acid, in soluble free, ester‐ and glycoside‐conjugated and cell wall‐bound forms. In addition, antioxidant enzyme activities and compound contents increased significantly in the beets and were subsequently lowered in a cultivar‐specific manner by salt stress + melatonin treatment. The current findings indicate that exogenous melatonin improved plant stress tolerance suppressing reactive oxygen species levels, increasing the antioxidant enzyme activities and compound contents and reducing the levels of Na+, maintaining an ionic homeostasis in the selected red and white sugar beet cultivars. It appears that melatonin application may help improve cultivar‐specific salt tolerance by enhancing ion homeostasis and betalain and phenolic acid production levels in beets.
Does succulence in woody plants delay desiccation, and is stored water used to maintain physiological function during drought conditions?
Authors: Guo Bihan , Arndt Stefan K. , Miller Rebecca E. , Szota Christopher , Farrell Claire 
Published: November 2024

AbstractSucculence is a trait that describes water storage in plant organs and tissues regardless of life form. Plants use the stored water to maintain physiological function and delay desiccation. However, it is unclear whether succulence in leaves, stems and roots of woody plants delays desiccation, whether it provides ‘utilizable water’ to maintain physiological function, or buffers changes in water status in drying soils through capacitance. We conducted a pot dry‐down experiment with nine shrub species to determine whether woody plants with greater leaf, stem, or root succulence have greater shoot utilizable water or capacitance. We also investigated whether greater succulence delays desiccation, represented by cumulative VPD, until evapotranspiration ceased or until utilizable water was exhausted. Greater leaf and stem succulence were strongly related to greater shoot utilizable water and capacitance. However, desiccation time was not delayed in plants with greater total shoot succulence, utilizable water, or capacitance. Instead, woody plants with greater root succulence had longer desiccation times. This suggests that woody plants use aboveground succulence to maintain physiological function and water status during drought, whereas root succulence extends desiccation time. Our study improves the mechanistic understanding of how woody plants use stored water to survive in dryland ecosystems.