bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETENTION OF SOME FLAVONES AND FLAVANONES IN FLOUR, GRAIN AND BRAN OF SORGHUM DURING STORAGE
Authors: QUEIROZ VALÉRIA APARECIDA VIEIRA , DE OLIVEIRA KÊNIA GRASIELLE , PAIVA CAROLINE LIBOREIRO , CARLOS LANAMAR DE ALMEIDA , DE MENEZES CÍCERO BESERRA , BARROS FREDERICO AUGUSTO RIBEIRO DE , PINHEIRO-SANT´ANA HELENA MARIA , ANUNCIAÇÃO PAMELLA CRISTINE 
Published: December 2018

ABSTRACT - Sorghum is associated with several functional benefits because it contains high levels of phenolic compounds, such as the flavonoids, flavones and flavanones. However, these compounds are sensitive to the period and conditions of storage. Thus, this work aimed to evaluate luteolin, apigenin, naringenin and eriodictyol retention in the sorghum genotypes SC319 (flour and grain) and TX430 (flour and bran) stored for 180 days at 4, 25 and 40 °C. These compounds were quantified by a high-performance liquid chromatograph equipped with a diode array detector. There was effect of the storage time, which favored the flavone and flavanone reduction in the evaluated genotypes. The storage temperature influenced the flavones more than the flavanone contents. The retentions ranged from 70.27 to 88.72% for luteolin, 69.04 to 99.15% for apigenin, 56.92 to 88.51% for naringenin and from 77.10 to 93.42% for eriodictyol at the three temperatures at the end of 180 days. Although flavones and flavanones were better preserved at 4 °C (about 88% of retention), at room temperature (25 °C) flavones and flavanones retentions were at least 77% and 85% after 180 days.Keywords: Sorghum bicolor (L.) Moench, storage losses, bioactive compounds, flavonoids retention. RETENÇÃO DE ALGUMAS FLAVONAS E FLAVANONAS EM FARINHA DE SORGO, GRÃO E FARELO DURANTE O ARMAZENAMENTO RESUMO – O sorgo está associado a várias propriedades funcionais pelo fato de conter altos níveis de compostos fenólicos, como flavonoides, flavonas e flavanonas. No entanto, estes compostos são sensíveis ao período e condições de armazenamento. Assim, este trabalho teve como objetivo avaliar a retenção de luteolina, apigenina, naringenina e eriodictilol nos genótipos de sorgo SC319 (farinha e grão) e TX430 (farinha e farelo) armazenados por 180 dias a 4, 25 e 40 °C. Estes compostos foram quantificados por cromatografia líquida de alto desempenho acoplada a detector de arranjo de diodos. Houve efeito do tempo de armazenamento, que favoreceu a redução de flavona e flavanona nos genótipos avaliados. A temperatura de armazenamento influenciou as flavonas mais do que o conteúdo de flavanona. As retenções variaram de 70,27 a 88,72% para luteolina, 69,04 a 99,15% para apigenina, 56,92 a 88,51% para naringenina e de 77,10 a 93,42% para eriodictilol nas três temperaturas no final de 180 dias. Embora as flavonas e flavanonas tenham sido melhor conservadas a 4 °C (cerca de 88% de retenção), em temperatura ambiente (25 °C), as retenções de flavonas e flavanonas foram pelo menos 77% e 85% após 180 dias.Palavras-chave: Sorghum bicolor (L.) Moench, perdas durante o armazenamento, compostos bioativos, retenção de flavonoides.
SIFAT-SIFAT ROLLBACK RECOVERY MENGGUNAKAN UNCOORDINATED CHECKPOINTING BERBASIS CAUSALITY STRENGTH
Authors: Sesa Junianto 
Published: December 2018

AbstractFault tolerance approach is the most popular computing application on computer devices in which depends on checkpoint uncoordinated. This alternative approach is based on checkpoint uncoordinated and logging message requiring all records, imposing works, memories and overhead becomes significant to communication. Recent studies have found that many applications on computer are send-determinism which can possibly design a new fault tolerance protocol. Thus, this research uses checkpoint uncoordinated protocol based causality strength, a send-determinism feature to record one part of the messages without restarting the process systematically when the error occurs. By drawing the protocol and proving its validity are required as the effective methods of this research. With this alternative approach, the protocol can functionally work where the only small portion of the message is recorded and domino effect does not occur.Keywords : Causality Strength, Domino Effect, Rollback Recovery, Uncoordinated Checkpointing AbstrakPendekatan toleransi kesalahan yang paling populer untuk aplikasi komputasi pada perangkat komputer bergantung pada checkpoint uncoordinated. Alternatif pendekatan tersebut berdasarkan pada checkpoint uncoordinated dan logging pesan mengharuskan pencatatan semua pesan, memaksakan pekerjaan memori/penyimpanan tinggi dan overhead yang signifikan pada komunikasi. Baru-baru ini telah diamati bahwa banyak aplikasi pada komputer bersifat send-determinism yang memungkinkan untuk mendesain protokol toleransi kesalahan baru. Sehingga penelitian ini menggunakan protokol checkpoint uncoordinated berbasis causality strength yang bersifat send-determinism yang hanya mencatat satu bagian dari pesan dan tidak perlu me-restart secara sistematis semua proses ketika kegagalan terjadi. Untuk menunjukkan bahwa penelitian ini berjalan sesuai dengan metode yang digunakan yaitu dengan menggambarkan protokol dan membuktikan kebenarannya. Dengan menggunakan pendekatan tersebut, dapat ditunjukkan bahwa protokol ini benar-benar berhasil dimana hanya mencatat sebagian kecil dari pesan dan tidak terjadi efek domino.Kata kunci : Causality Strength, Efek Domino, Rollback Recovery, Uncoordinated Checkpointing
Meningkatkan Kemampuan Berpikir Kreatif Matematis Siswa SMA Melalui Pembelajaran Open-Ended Pada Materi SPLTV
Authors: Ikromi Syaiful Lutfi 
Published: December 2018

Abstract This aim of this study is to descript mathematics thinking creative ability of high school students (SMA) through open ended problem learning of SPLTV. Type of this research is descriptive qualitative. The subjects of this research are the students of class XII SMA. The steps of the research are namely (1) orientation, (2) material supply, (3) giving and solving open ended problem, (4) presentation and (5) conclusion. The mathematics creative thinking ability consists of (a) fluency, ability of the student to give a right answer fluency, (b) flexibility, ability of the student for using various manners in problem solving, (c) novelty, ability of the student to give a new answer and different with other student. The results of this research, is that the students have ability of mathematics creative thinking.Keywords: creative thinking, open ended problem, SBLTVAbstrak Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir kreatif matematis siswa SMA melalui pembelajaran open ended problem materi SPLTV. Jenis penelitian ini, yaitu deskriptif kualitatif. Subjeknya adalah siswa kelas XII SMA. Tahap pembelajaran dalam penelitian ini adalah (1) Orientasi, (2) pembekalan materi, (3) penyajian dan pengerjaan soal open ended, (4) presentasi, (5) kesimpulan. Kemampuan berpikir kreatif matematis siswa meliputi: (a) fluency, kemampuan siswa lancar dalam memberikan jawaban benar, (b) flexibility, kemampuan siswa dalam menggunakan berbagai cara penyelesaian masalah, (c) novelty, kemampuan siswa dalam memberikan jawaban yang baru dan berbeda dengan siswa lain. Penelitian ini hasilnya, bahwa siswa mempunyai kemampuan berpikir kreatif matematis.Kata kunci: berpikir kreatif, open ended problem, SPLTV
Barriers and Solutions to Developing Future Therapies for Pulmonary Hypertension
Authors: Graham Brian , Fernandes Peter , Gu Sue 
Published: December 2018

Pulmonary hypertension (PH) and its subset, pulmonary arterial hypertension (PAH), are rare diseases with a significant unmet need. Between the 1980s and 2010s, the 5-year survival rate for PAH after diagnosis improved from 34% to 65%,12 but remains unacceptably low. Since the introduction of vasodilator therapy, 34 important advances have been made in the understanding of the disease pathophysiology and development of targeted therapies. There are now 14 US Food and Drug Administration (FDA)-approved therapies that target 3 distinct pathways that contribute to PAH, and additional therapeutic targets are currently under investigation in phase 1, 2, and 3 clinical trials.5 However, there have been major challenges in PH medication development to date, including: 1) only one medication approved for pediatric PAH; 2) focusing on vasodilator therapy rather than targeting the underlying pathogenesis of the disease; 3) no medications approved for PH World Health Organization (WHO) Groups 2, 3, and 5; and 4) several recent high-profile clinical failures after promising preclinical studies.The focus and goal of the PH research community should be directed at identifying new options and solutions for patients. The field must ensure that the approaches used for clinical trials to develop orphan drugs maximize the scarce resources available for recruiting subjects, and are directed toward making safe and effective therapies available in a timely manner. Therefore, there is a critical need to coordinate and harmonize innovative approaches within the field, including strengthening translational research to deliver promising candidates and optimize the designs, endpoints, and biomarkers to conduct safe and efficient clinical trials.
High Anti-HCV Seroprevalence and Low Performance of ICT Strip in Diagnosing Hepatitis C Virus Infection in Children in Enugu Metropolis
Authors: Ezeilo Maryann C. , Engwa Godwill A. , Iroha Romanus I. , Odimegwu Damian N. 
Published: December 2018

Background:The lack of a vaccine for Hepatitis C virus (HCV) places children at a high risk of contracting the infection. It becomes necessary to accurately diagnose this infection for proper treatment as well as identifying potential risk factors for effective management.Aim:This study was conceived to assess the test performance of the commonly used Immunochromatographic test (ICT) strip and identify the associated clinical manifestations and risk factors of HCV in children in Enugu Metropolis.Method:A cross-sectional study involving randomly selected 270 children below six years of age was conducted in Enugu Nigeria. The subjects were screened for anti-HCV by ICT and Enzyme-Linked Immunosorbent Assay (ELISA) and the demographic, signs and symptoms and risk factors were collected.Results:A total of 50 out of 270 children were positive for anti-HCV with a seropositivity of 18.5%. ICT strip had a very low sensitivity of 38.00% with an accuracy of 88.52% in detecting anti-HCV. The presence of dark urine was associated (p= 0.01) with HCV infection.Conclusion:A seroprevalence of 18.5% of Anti-HCV was found in children below six years old in Enugu metropolis and the performance of ICT in diagnosing HCV infection was poor compared to ELISA.
Tetrahydrocarbazoles as Novel Class of DNA Biosynthesis Inhibitors in Bacteria
Authors: Ivanenkov Yan A. , Osterman Ilya A. , Komarova Ekaterina S. , Bogdanov Alexey A. , Sergiev Petr V. , Dontsova Olga A. , Sofronova Alina A. , Terentiev Victor A. , Filkov Gleb I. , Yamidanov Renat S. , Majouga Alexander G. , Bezrukov Dmitry S. , Deyneka Ekaterina V. , Skvortsov Dmitry A. 
Published: December 2018

Background:
High-throughput screening (HTS) of large-compound libraries is a convenient
and cost-effective tool for novel drug discovery. However, in many cases, HTS platforms
are not well adapted to perform cell-based screening assay with simultaneous identification of the
mechanism of action for active compounds.

Methods:
Previously, we have described a unique double-reporter system that can be used to reveal
compounds having antibacterial activity. This construction is based on two genes of Katushka2S
and RFP that encode proteins with different imaging signature. The upregulated expression
of the first gene attributes directly to translation inhibition in prokaryotes while the high expression
of the second one is unambiguously associated with DNA biosynthesis restriction (SOS-response).

Results:
In the current work, we have applied this system for the identification of novel smallmolecule
compounds with antibacterial activity in HTS scale. Compounds were selected from the
ChemDiv in-house collection (of total 47K molecules) following the maximum diversity in structure.
Based on the obtained results, we have revealed a small series of tetrahydrocarbazole derivatives
with antibacterial activity. The hit compound inhibited bacterial growth with a MIC value of
21 μg/ml and blocked DNA biosynthesis. No activity towards translation has been observed. In
spite of a relatively moderate potency, as compared to the control sample (erythromycin, MIC=3
μg/ml), this molecule provides good selectivity index (SI>333, HEK239).

Conclusion:
Tetrahydrocarbazole derivatives can be properly regarded as an attractive starting
point for further development and optimization.
La necesidad de herramientas para la co-creación del paisaje urbano
Authors: Intveen Pérez Hans 
Published: December 2018

RESUMEN
Con el objetivo de acercarse a una participación ciudadana oportuna, legible y medible, en el contexto del desarrollo del paisaje urbano en la ciudad latinoamericana, se desarrolla una herramienta para la extracción de información espacial desde la comunidad, a través de patrones de diseño aplicables a la obra urbana. Se sistematiza una experiencia de diseño participativo en la Región de Antofagasta —en el marco del Programa de Recuperación de Barrios del Ministerio de Vivienda y Urbanismo—, demostrando la importancia de acercarse a un co-diseño del paisaje urbano a nivel de barrio, ciudad y territorio.
Estado Actual de la Planificación de las Cuencas Hídricas en el Departamento de Sucre (Colombia)
Authors: Hernández Arrázola Angelina María , Landero Madera Keila Esther , Rodríguez Miranda Juan Pablo 
Published: December 2018

RESUMEN
El estado de las principales fuentes hídricas del Departamento de Sucre; el deterioro que se evidencia en la fauna, flora y poblaciones aledañas a estas; y la inexistencia de información sobre el manejo de territorios considerados como ecosistemas especiales, en este caso en particular, las áreas pertenecientes a cuencas hidrográficas, deja ver el estado de la planificación de las cuencas hídricas en el Departamento. Tal situación advierte la necesidad de una pronta ordenación, que permita mantener o restablecer el equilibrio entre el aprovechamiento de los servicios ecológicos de las cuencas hídricas y el estado natural de las mismas.
BULANIK REBA İLE BİR MOBİLYA İMALAT FİRMASINDA ERGONOMİK RİSK DEĞERLENDİRMESİ
Authors: ERGİNEL Nihal , TOPTANCI Şura , ACAR İlgın 
Published: December 2018

İşyerinde
uygun olmayan vücut çalışma duruşları, gürültü, sıcaklık, vb. ergonomik riskler
sonucunda ortaya çıkan işe bağlı kas-iskelet sistemi rahatsızlıkları (İKİSR),
sanayileşmiş ülkelerde karşılaşılan büyük bir sağlık problemidir. İşyerinde
alınacak tedbirlerle İKİSR büyük ölçüde önlenebilmektedir. Hızlı Tüm Vücut
Değerlendirmesi (Rapid Entire Body Assessment-REBA) yöntemi, İKİSR için
çalışanın tüm vücudunu göz önüne alması dolayısıyla, çalışma duruş analizlerini
yapmak ve yapılan işlerin risk düzeylerini belirlemek amacıyla yaygın olarak
kullanılan gözlemsel araçlardan biridir. REBA yönteminde risklerin
değerlendirilmesi esnasında uzmanların görüşlerinin bir sınıflandırma ile tarif
edilmesi ve sözel değerlerin kullanılması nedeniyle belirsiz durumlar ortaya
çıkmaktadır. Bu belirsizlikler bulanık sayılar kullanılarak analiz edilebilir.

Bu
çalışmada, bir mobilya fabrikasında yapılan işlerin İKİSR açısından ne kadar
riskli olduğunun ve bu risklerin önlenmesi için yapılacak müdahalelerin
belirlenmesi amaçlanmıştır. Çalışma duruşundan kaynaklanan riski
değerlendirmede Bulanık REBA yöntemi kullanılmıştır.
Bulanık REBA yöntemi iki farklı hesaplama metodolojisini ele alarak
uygulanmıştır. Bu çalışmada, incelenmeye
alınan farklı istasyonlara ait altmış üç adet duruş fotoğrafından ayrıntılı olarak iki
çalışma duruşunun risk değerlendirilmesi anlatılmıştır. Ayrıca, iki iş
istasyonunda iş yükünü dolaylı olarak etkileyen gürültü, toz, sıcaklık, nem ve aydınlatma
düzeyleri ölçülmüştür. Ardından, analiz sonuçlarına göre ortaya çıkan riskleri
azaltmak için yapılabilecek ergonomik iyileştirmeler ele alınmıştır.
Territorios de agua: infraestructura agrícola, reforma agraria y palma de aceite en el municipio de Marialabaja (Bolívar)
Authors: Quiroga Manrique Catalina , Vallejo Bernal Diana 
Published: December 2018

Las dinámicas de despojo y acaparamiento de agua son un eje central en investigaciones recientes que reconocen las relaciones asimétricas de poder y el poder de la naturaleza misma en el manejo, uso y control de los recursos. Sin embargo, no son muchos los trabajos sobre las alternativas de gestión local del agua. Este artículo aporta a este conjunto de literatura a partir de un acercamiento etnográfico al distrito de riego de Marialabaja (Bolívar), en el Caribe colombiano. El análisis de la construcción de esta obra ayuda a entender cómo la infraestructura se apropia como parte del territorio, a la vez que genera relaciones desiguales de acceso al agua.
También muestra las consecuencias directas de una política de desarrollo rural en las vidas cotidianas de las poblaciones locales.
Red de soporte social y apoyo comunitario en miembros de una organización de desplazados por violencia política residentes en Cañete, Perú/Social Support Network and Community Support Among Members of an Organization of Persons Displaced by Political Violence Residing in Cañete, Peru
Authors: Schoof Aguirre Ma. Teresa , Manzanares Medina Eduardo , Grimaldo Muchotrigo Miriam 
Published: December 2018

EspañolEl objetivo de la presente investigación fue determinar la relación entre la red de soporte social y el apoyo comunitario en los miembros de una organización de personas desplazadas por violencia política. Para tal fin, el estudio descriptivo correlacional incluyó a 80 participantes (49 mujeres y 31 hombres) con una edad promedio de 45.79 años (DE = 11.41), quienes residían en una provincia de Lima y provenían, en su mayoría, del departamento de Ayacucho. Se les administró el Cuestionario de Red Social (SNQ) y el Cuestionario de Apoyo Comunitario Percibido (PCSQ). Entre los principales resultados, se encontró que el componente Integración y Participación Comunitaria del PCSQ correlaciona con dos funciones y dos categorías del SNQ. Se presenta asociación positiva estadísticamente significativa con la función guía cognitiva (rs = .32), la función socialización (rs = .24) y la categoría satisfacción (rs = .24) y asociación negativa y estadísticamente significativa con la categoría heterogeneidad (rs = -.23). Se discuten las implicancias de los presentes hallazgos. EnglishThe present study’s aim was to determine the relationship between the social support network and community support among members of an organization of persons displaced by political violence. The correlational-descriptive research included 80 individuals (49 females and 31 males) with a mean age of 45.79 years old (SD = 11.41), who reside in a province of Lima and came, mostly, from the department of Ayacucho. Participants completed the Social Network Questionnaire (SNQ), as well as the Perceived Community Support Questionnaire (PCSQ). Among the main findings, we found that the Integration component and Community Participation from the PCSQ correlate with two functions and two categories from the SNQ. Specifically there is a statistically significant positive association with the Cognitive Guide function (rs = .32), the Socialization function (rs = .24) and the Satisfaction category (rs = .24); and a statistically significant negative association with the Heterogeneity category (rs = -.23). Implications of the results obtained will be discussed in the present paper.
RELIGIOSIDADE, DEUS E O DIABO NO GRANDE SERTÃO: VEREDAS DE GUIMARÃES ROSA
Authors: Marcelino Bernadete Alves de Medeiros 
Published: December 2018

O objetivo deste texto é apresentar uma reflexão sobre religiosidade, Deus e o Diabo presentes em algumas partes do Grande Sertão: Veredas, de Guimarães Rosa. Visando refletir os quesitos apresentados, adotamos como método, além da leitura da obra, consultas a diversificadas abordagens, criando possibilidades para compreendê-la um pouco melhor. Grande Sertão: Veredas é um clássico da literatura brasileira que a partir de uma riquíssima combinação de gêneros literários, traz à tona “subconscientes” do Brasil. Uma realidade múltipla, que ao envolver inúmeros fatores, revela-nos um universo bastante expressivo sobre religiosidade, Deus e o Diabo que emanam das ideias do homem do sertão. Este, que diante das intempéries da vida, busca incessantemente explicações para o bem e do mal que vivencia no seu dia a dia.
Software para evaluación de hardware pedagógico utilizable en la educación universitaria
Authors: Mongelo Luis Mariano , Alcaraz Bernardo Pedro , Dávila Marcela Fabiana , Garabato Claudio Fabián , Sandoval Clara Eva , Levi Marcelo Jorge , Panik Gabriel Edgardo , Villarruel Maria Laura 
Published: December 2018

Para lograr que la educación brindada sea de calidad, es necesario que las nuevas tecnologías que existen en el área sean ponderadas y clasificadas en distintas categorías con el fin de optimizar el uso de las mismas.
El presente proyecto está basado en el desarrollo de un software que permita la evaluación con fines pedagógicos del mobiliario, software y hardware existentes, con el fin de lograr que las tecnologías de la información y la comunicación (TIC’s) aporten un progreso en la calidad de la didáctica áulica, que permitan desarrollar la inclusión de los alumnos diversos funcionales, mediante la utilización de técnicas de enseñanzas, basadas en “software” y “hardware” específicos.
PEMERTAHANAN BAHASA SUNDA DALAM UPACARA PERNIKAHAN TRADISIONAL DI KABUPATEN BANDUNG
Authors: Wagiati Wagiati , Zein Duddy 
Published: December 2018

The aim of this research is to explain the methods for maintaining the use of Sundanese language in the Sundanese Traditional Wedding Ceremony in Bandung Regency and to describe the factors that influence them. The method used in this reasearch was a descriptive-qualitative method. The data sources were the Sundanese traditional wedding ceremony in Kabupaten Bandung. The results show that the methods for maintaining the use of Sundanese language in the Sundanese traditional wedding Ceremony in Kabupaten Bandung include the traditional welcoming ceremony for bride and groom by lengser, saweran, ngaleupaskeun japati, door opening, and sungkem. The factors that influence the insistence of maintaining the usage of Sundanese language in the Sundanese Traditional Wedding Ceremony are to preserve the cultural identity and the cultural background of the bride and groomâ€™s family.Â Â AbstrakTujuan penelitian ini adalah mendeskripsikan bentuk-bentuk pemertahanan bahasa Sunda dalam upacara pernikahan adat Sunda di Kabupaten Bandung dan menjelaskan faktor-faktor yang mempengaruhinya. Metode yang digunakan adalah metode kualitatifdeskriptif. Sumber datanya adalah upacara pernikahan adat Sunda di Kabupaten Bandung. Berdasarkan data tersebut dilakukan analisis terhadapnya. Hasil penelitian menunjukkan bahwa bentuk pemertahanan bahasa Sunda pada upacara pernikahan adat Sunda di Kabupaten Bandung, Jawa Barat meliputi bentuk penjemputan oleh lengser, saweran inti, ngaleupaskeun japati, buka pintu, dan sungkem. Faktor yang menyebabkan terjadinya pemertahanan bahasa Sunda pada upacara pernikahan adat Sunda adalah mempertahankan identitas kultural dan latar belakang kultural keluarga yang melangsungkan upacara pernikahan tersebut.