bluuebunny/crossref_metadata_2025_split huggingface dataset:
Codesign and evaluation of advanced therapeutic information resources for and with families of children with neurological conditions: a mixed methods cross-sectional study
Authors: Meagher Christian Elias , Kariyawasam Didu S , Concepcion Kristine A Elias , Dale Russell , Hetherington Kate , Mohammad Shekeeb , Palmer Elizabeth Emma , Woolfenden Susan , Farrar Michelle Anne 
Published: November 2024

ObjectiveParents and caregivers of children with neurological conditions express interest in new and developing treatments and trials; however, they have limited knowledge of, and access to, reliable information. This study aims to empower and equip decision-making and support communication in the application of advanced neurotherapeutics and personalised medicine, covering gene therapy, stem cell therapy, neurostimulation and neuroimmunotherapies.DesignA suite of online psychoeducational resources has been created and evaluated to establish implementation success. A codesign approach was incorporated in this mixed methods cross-sectional study.SettingQuaternary children’s hospital network.PatientsAcross three phases, 105 parents of children with neurological conditions, clinicians and advocacy group representatives participated.InterventionsA suite of psychoeducational resources about advanced therapeutics in clinical trials was codeveloped with parents and evaluated.Main outcome measuresAcceptability, Appropriateness, and Feasibility of Intervention Measures, Preparedness for Decision-Making Scale, Decision Self-efficacy Scale and open-ended qualitative feedback.ResultsThe resources provide an acceptable, appropriate, credible and feasible source of information. Parents also established they help with preparedness and confidence in decision-making regarding the applications of neurotherapeutics.ConclusionsThis study and its results are aligned with, and supports, the needs and preferences of caregivers of children with neurological conditions, promoting information provision, healthcare engagement and clinical decision-making. These resources will form a foundation for accurate and contemporary scientific knowledge that is distilled and available to a wide range of stakeholders.
Internet addiction prevalence and associated factors among secondary-level private school students in urban Nepal: a cross-sectional study
Authors: Gautam Prapti , Khanal Ganga , Shrestha Khadga Bahadur , Sapkota Sujata 
Published: November 2024

ObjectiveTo estimate the prevalence of internet addiction and its associated factors among secondary-level private school students in an urban municipality in Nepal.DesignCross sectional.SettingPrivate schools in Budhanilkantha Municipality, Kathmandu District in Nepal.Participants376 secondary-level (grades 9–12) school students.Outcome measuresInternet addiction prevalence was the primary outcome measure. We conducted a cross-sectional survey using a self-administered structured questionnaire containing information on participants’ sociodemographic profile, technological factors associated with internet use along with Young’s internet addiction test, insomnia severity index and depression anxiety stress scales to assess internet addiction and associated factors. Pearson’s χ2 tests and binary logistic regression were performed to examine the association between dependent and independent variables at a 5% level of significance.ResultThe prevalence of internet addiction was 51.10% (95% CI 46 to 55.60). Students who lived alone or with friends in an apartment had a higher likelihood of internet addiction compared with those living with their parents (adjusted odds ratio (AOR) 2.89, 95% CI 1.03 to 8.11). On the other hand, students residing in hostels were less likely to be affected (AOR 0.21, 95% CI 0.06 to 0.76). Additionally, spending 2 or more hours online per day was associated with a higher risk of internet addiction (AOR 2.09, 95% CI 1.20 to 3.63) compared with those who spent less than 2 hours per day online. Individuals with severe to extremely severe depression were more likely to have internet addiction (AOR 2.99, 95% CI 1.03 to 8.66) compared with individuals without depressive symptoms. Furthermore, a notable association was observed between internet addiction and insomnia. Individuals who experienced mild to moderate insomnia (AOR 5.19, 95% CI 2.93 to 9.19) and severe insomnia (AOR 21.09, 95% CI 2.09 to 212.91) were at significantly higher risk of internet addiction compared with those without clinically significant insomnia.ConclusionPrevalence of internet addiction among school-going adolescents in urban Nepal is high. Living situations, average time spent online, depression and insomnia are potential drivers of internet addiction.
Perspectives on the sustained engagement with digital health tools: protocol for a qualitative interview study among people living with Inflammatory Bowel Disease or irritable bowel syndrome
Authors: Olson Jenny L , Palumbo Amelia , Desjardins Chloé , Wicks Chantel , Bhopa Shania , Cheyne Kelsey , D'Silva Adrijana , Graff Lesley A , Narula Neeraj , Rodrigues David M , Fernandes Aida , Marshall Deborah A , Moayyedi Paul , Presseau Justin 
Published: November 2024

IntroductionDigital health tools can be beneficial in the care of patients with chronic conditions and have the potential for widespread impact as readily scalable and cost-effective health interventions. However, benefits are often contingent on users sustaining their engagement with these tools over time. Sustained engagement with digital health tools can be challenging, and high rates of attrition from digital interventions are common. Inflammatory Bowel Disease (IBD) and irritable bowel syndrome (IBS) are prominent gastrointestinal conditions resulting in significant burdens for individuals and society. Emerging evidence suggests digital health tools can be beneficial for IBD and IBS management; however, it is not clear what barriers and enablers are experienced by people living with these conditions to sustaining their engagement with these tools, when necessary. Such knowledge could inform the tailoring of new and existing digital health tools to the needs of people living with IBD and/or IBS. This study will seek to identify the barriers and enablers of sustained engagement with digital health tools among adults living with IBD and/or IBS.Methods and analysisWe will conduct semistructured interviews with a purposive sample of approximately 30 adults (>18 years) who (a) reside in Canada, (b) self-report that they have been diagnosed with IBD and/or IBS, (c) have ever used a digital health tool (ie, any application/platform) to manage their condition and (d) are capable of providing informed consent. Interviews will be audio and video recorded and transcribed verbatim. Data will be coded deductively and barriers and enablers to sustained engagement will be categorised in accordance with the Theoretical Domains Framework. Data analysis will be verified by a patient research partner.Ethics and disseminationThe study has been approved by the Ottawa Health Science Network Research Ethics Board. The findings will inform the codevelopment of strategies to overcome modifiable barriers and leverage identified enablers of sustained engagement with digital health tools for IBD and IBS care. These strategies can inform the design of new, or modifications to existing, digital health tools for IBD and IBS care where sustained engagement is desirable. Strategies will be compiled into a guidebook and disseminated via the Inflammation, Microbiome and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects (IMAGINE) Strategy for Patient Oriented Research chronic disease network in Canada.
Knowledge of antibiotics and antibiotic resistance, antibiotic use and eHealth literacy among nursing students in Thailand: a cross-sectional study
Authors: Jianvitayakij Soontaree , Niyomyart Atsadaporn , Junsawang Chuenjit , Bualoy Wunwisa , Butsing Nipaporn , Monkong Supreeda , Voss Joachim G 
Published: November 2024

ObjectivesAntibiotic resistance poses a major global public health threat. However, research on this issue is limited, especially among nursing students. This study aims to examine knowledge of antibiotics and antibiotic resistance, antibiotic use, and eHealth literacy in Thailand.DesignA cross-sectional study was conducted using an online self-administered questionnaire. The WHO Antibiotic Resistance: Multi-Country Public Awareness Survey and the eHealth Literacy Scale were used. Descriptive and multiple regression analyses were performed.SettingThailand’s North, South, Central and Northeast between January and February 2024.ParticipantsA total of 1180 nursing students aged 18 or older, from first to fourth year and fluent in Thai, were invited to participate.ResultsThe participants were mostly female (89.8%), with an average age of 20.64±1.81 years. Over half of the respondents (67.7%) have used antibiotics, mistakenly believing that antibiotics could treat colds and influenza (70.3%), malaria (66.8%), measles (63.6%) and sore throats (60.9%). About 71.5% recognised the impact of antibiotic resistance on themselves and their families, but 93.1% incorrectly believed antibiotic resistance means the body resists antibiotics. Participants scored 35.92±4.21 out of 40 on eHealth literacy. In a multiple regression analysis, three factors predict knowledge of antibiotic resistance: knowledge of antibiotics (B=0.199, p<0.001, 95% CI 0.165 to 0.234), eHealth literacy (B=0.078, p<0.001, 95% CI 0.056 to 0.100) and academic year (B=0.271, p<0.001, 95% CI 0.184 to 0.358), with knowledge of antibiotics being the most impact (β=0.318). These three variables explained 23.7% of the variance in antibiotic resistance knowledge scores.ConclusionsDespite high eHealth literacy, nursing students hold misconceptions about antibiotic treatable conditions and insufficient knowledge of antibiotic resistance. This highlights the need to integrate antibiotic contents into nursing curricular and enhance eHealth literacy for better access and navigate health information.
Gender-sensitive and intersectionality-informed health indicators for health reporting: a scoping review protocol
Authors: Gencer Hande , Saß Anke-Christine , Prütz Franziska 
Published: November 2024

IntroductionGender is a well-established social determinant of health and health (in)equality. Gender-sensitive health indicators for health monitoring and health reporting can support gender mainstreaming in relevant policy areas and inform strategies to promote gender equality. They generally lack theoretical approaches to explain gender inequalities in health in the context of individual, social and structural circumstances. Gender-sensitive and intersectionality-informed health indicators provide a more accurate and nuanced picture of health outcomes and risks but are often lacking. The aim of this scoping review is to map the evidence on gender-sensitive and intersectionality-informed indicators for health reporting in order to support the development of an indicator set for German Federal Health Reporting.Methods and analysisThis scoping review follows Arksey and O’Malley’s methodological framework and its extension by Levacet aland will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. We will conduct a database search complemented by a backward citation search using English search terms to find research articles and grey literature (eg, reports, policy/working papers, book chapters) reporting on gender-sensitive health indicators in the context of health reporting in the European Union-27 and Organisation for Economic Cooperation and Development published since 2014. Electronic databases include Medline, PsycINFO, Embase, Scopus, CINAHL and Cochrane Library. Other resources include targeted searches on websites relevant to national and international health reporting and a Google Search to include further eligible literature. After removing duplicates, two reviewers will independently screen all titles/abstracts and full texts for eligibility for inclusion and extract the data from included articles using a data extraction form. The results will be synthesised both narratively and descriptively and, where appropriate, presented in tables and graphs.Ethics and disseminationNo ethical approval is required for this study. Findings will be disseminated through peer-reviewed publication, conference presentations and meetings with relevant stakeholders in health monitoring and reporting.
Cardiopulmonary exercise testing in aortic stenosis patients before and after aortic valve replacement
Authors: Bellander Carl , Nilsson Henric , Nylander Eva , Hedman Kristofer , Tamás Éva 
Published: November 2024

BackgroundKnowledge about how patients with symptomatic aortic stenosis (AS) perform on cardiopulmonary exercise testing (CPET) is sparse. Since exercise testing in patients with symptomatic AS is not advised, submaximal parameters could be of special interest. We aimed to investigate maximal and submaximal physical capacity by CPET before and 1 year after surgical aortic valve replacement (sAVR) in patients with severe AS.MethodsIn this prospective longitudinal study, 30 adult patients (age 66±10 years) with severe AS referred for sAVR underwent maximal CPET (respiratory exchange ratio ≥1.05) on a bicycle ergometer before (PRE) and 1 year after (POST) sAVR. Normally distributed data are presented as mean (±SD) and non-normally distributed data are presented as median (IQR).ResultsMedian peak workload increased by 8% from 133 (55) watts at PRE to 144 (67) watts at POST (p<0.001). Median ventilatory threshold (VO2@VT) increased from 1216 (391) to 1328 (309) mL/min (p=0.001, n=28). Mean peak oxygen uptake (peakVO2) was not significantly different between PRE and POST; 1871±441 vs 1937±404 mL/min (p=0.08). The oxygen uptake efficacy slope (OUES) was significantly correlated to PeakVO2 at both PRE (r=0.889, p<0.05) and POST (r=0.888, p<0.05)ConclusionPhysical work capacity was improved 1 year following sAVR, in terms of higher median peak workload and VO2@VT. The strong correlation between the submaximal variable OUES and peakVO2suggests that OUES might be a useful surrogate of peakVO2in this group of patients where maximal exercise testing is not always recommended.
Faecal Immunochemical Testing in Symptomatic Primary Care Patients: A Diagnostic Accuracy Study
Authors: Ball Alex J. , Ray Meghna , Manji Arif , Aziz Imran , Sargur Ravishankar B. , Kurien Matthew 
Published: November 2024

Aim: The faecal immunochemical test (FIT) is now widely used in English primary care to triage people who exhibit signs or symptoms of colorectal cancer (CRC). National guidelines for FIT implementation were based on data that acknowledged limitations. This study examines FIT accuracy in primary care patients with low‐ and high‐risk symptoms of CRC.Methods: This study describes a retrospective cohort study in South Yorkshire, UK (n = 2029). Consecutive symptomatic adult patients in primary care undergoing a FIT between 01/04/2021 and 30/04/2021 were assessed. A threshold > 10 μg Hb/g was defined as a positive FIT result. Lower gastrointestinal tract (LGI) investigations were the reference standard. Follow‐up over 24 months was used to identify serious colorectal diseases (CRC, high‐risk polyps and inflammatory bowel disease [IBD]).Results: Five hundred and fifteen (25.4%) patients had a positive FIT. The CRC prevalence was 1.2% (24/2029). Nineteen (79.1%) of the 24 CRC cases had NG12 symptoms, with two (8.3%) having a negative FIT. For CRC detection, FIT showed 91.7% sensitivity (95% CI: 71.5%–98.5%), 75.4% specificity (95% CI: 73.4%–77.2%), 4.3% positive predictive value (PPV) (95% CI: 2.8%–6.5%) and 99.9% negative predictive value (NPV) (95% CI: 99.5%–99.97%). Combining CRC, high‐risk polyps and IBD increased PPV and specificity but decreased sensitivity and NPV.Conclusions: In primary care, FIT safely triages patients having at‐risk CRC risk symptoms. Negative FIT results indicate a low likelihood of CRC and supports safety‐netting interventions.
Comparison of Mortality and Postoperative Complications Between Open and Laparoscopic Repair of Perforated Peptic Ulcer
Authors: Eghbali Foolad , Banijamali Mahdi , Jahanshahi Fatemeh , Tizmaghz Adnan , Rezvani Hamid , Ghadimi Parmida , Madankan Ahmad , Alipour Homan , Vaseghi Hamed , Haghmoradi Meisam , Bahardoust Mansour , Mosavari Hesam 
Published: November 2024

Background: Perforated peptic ulcer (PPU) is one of the common complications of peptic ulcers. Open repair (OR) is the traditional surgical treatment for this condition, but with advances in laparoscopic and minimally invasive surgery, laparoscopic repair (LR) has gained popularity. Many studies have compared the effectiveness of OR vs. LR for PPU. However, the superiority of one method over the other remains a topic of debate. We conducted this review to investigate the advantages and disadvantages of LR over OR.Methods: PubMed, Scopus, Google Scholar, and Web of Science were searched from 2000 to 2022 for systematic reviews and meta‐analyses comparing OR and LR for PPU. Previous studies included seven postoperative outcomes, including mortality, reoperation, postoperative ileus, intra‐abdominal abscess, leakage, pneumonia, and wound infection. Two researchers independently extracted data and assessed the quality of the eligible studies using the AMSTAR 2 tool.Results: Five systematic reviews and meta‐analyses were included, involving 36 studies. The pooled estimate showed that the risks for mortality, postoperative ileus, and wound infection were significantly lower with LR. In comparison, the risks for reoperation and leakage were less with OR. Based on the pooled estimate, no significant relationship was noted between the surgical method and intraabdominal abscess or postoperative pneumonia.Conclusion: Evidence suggests that in stable patients with PPU, LR is better than OR in terms of mortality. However, more high‐quality evidence is needed to determine which is more appropriate for different circumstances (e.g., unstable or high‐risk patients).
Electrocatalytic Barrier Comprising Polar SnO2 Quantum Dots Anchored Within Porous Carbon Microspheres Prepared by Spray Drying Process for Li–S Batteries
Authors: Baek Kun Woo , Oh Geon Hui , Saroha Rakesh , Kang Dong-Won , Park Gi Dae , Cho Jung Sang 
Published: November 2024

Hypothesis: Porous carbon microspheres (PCMs) with embedded tin di‐oxide (SnO2) quantum dots (QDs) (P‐SnO2@PCMs) are synthesized and employed as polysulfide barriers to enrich the electrochemical properties.Experiments: This composite structure is prepared by spray drying procedure and followed by heat‐treatment, resulting in well‐arranged macropores with a diameter of 59 nm generated by the polystyrene (PS) nanobeads (ϕ = 150 nm) decomposition. P‐SnO2@PCMs is functioned as an electrocatalytic interlayer and offer advantages such as reduced diffusion length for charged particles that guarantees immediate transfer, improved electrode wetting due to efficient electrolyte infiltration, and accommodation of large volume fluctuations during the redox reactions. Furthermore, the incorporation of polar SnO2 QDs within the microspheres allows for efficient chemical confinement and alteration of trapped polysulfide species due to catalytic activity, leading to an extensive use of the active material.Findings: Advancing from the nanostructural eminence, lithium–sulfur (Li–S) cells paired with P‐SnO2@PCMs‐coated separator and conventional sulfur electrode showed outstanding rate performance (321 mA h g−1 at 2.0 C) and prolonged cyclic steadiness at 0.1 C. This innovative synthesis strategy provides valuable insights for developing novel nanostructures applicable to various rechargeable devices.
Deep Structure Usage of Electronic Patient Records: Enhancing the Influence of Nurses’ Professional Commitment to Decrease Turnover Intention
Authors: Chang Hao-Yuan , Huang Guan-Ling , Lotus Shyu Yea-Ing , May-Kuen Wong Alice , Tai Shih-I , Cheng T. C. E. , Teng Ching-I 
Published: November 2024

Background: Organizational turnover exacerbates the shortage of nurses in the global workforce. However, no study has yet explored how deep structure usage—nurses’ integration of electronic patient records into nursing practice delivery—reduces their turnover intention and moderates the impact of affective, continuance, and normative professional commitment on their turnover intention.Aims: To ascertain (1) the linkage between the deep structure usage of electronic patient records and nurses’ organizational turnover intention and (2) the moderating role of deep structure usage on the associations between elements of commitment (affective, continuance, and normative) and turnover intention.Methods: Using a cross‐sectional survey and proportionate random sampling by ward unit, we collected data from 417 full‐time nurses via a self‐administered questionnaire. We performed hierarchical regression analyses to test the study hypotheses.Results: Deep structure usage was not directly related to organizational turnover intention (β = −0.07, p = 0.06). However, the results suggested that deep structure usage may enhance the effect of high affective commitment on nurses’ organizational turnover intention (β = −0.09, p = 0.04), while potentially mitigating the effect of low continuance commitment on organizational turnover intention (β = 0.10, p = 0.01).Conclusions: Deep structure usage of electronic patient records helps to ease nurses’ workload and facilitates their retention, which is particularly due to their affective commitment (attachment) but not their continuance commitment (switching costs).Implications for Nursing Management: Nursing management may advise hospital management that medical records systems need to be improved and fully embedded for nursing care delivery, as a more in‐depth use of these systems can help to retain nurses.
Visceral Adiposity as an Independent Risk Factor for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus: A Retrospective Study
Authors: Wu Rui-Ling , Chen Niyao , Chen Yanni , Wu Xiaohong , Ko Chih-Yuan , Chen Xiao-Yu 
Published: November 2024

Background: Diabetic peripheral neuropathy (DPN) impacts approximately 50% of individuals with Type 2 diabetes mellitus (T2DM), leading to severe complications such as foot ulcers and amputations. Notably, visceral adiposity is increasingly recognized as a pivotal factor in augmenting the risk of DPN. We aim to evaluate the correlation between obesity‐related body composition, particularly visceral fat, and DPN to facilitate early identification of high‐risk patients with T2DM.Methods: This cross‐sectional analysis encompassed 113 T2DM patients from the Department of Endocrinology and Metabolism at the Second Affiliated Hospital of Fujian Medical University, conducted between September 2020 and January 2021. Patients were categorized into two cohorts: those with DPN (DPN group) and those without (NDPN group). We utilized bioelectrical impedance analysis (BIA) to determine body measurements, such as weight and visceral fat area, in addition to collecting clinical and biochemical data. Logistic regression was employed to analyze the data.Results: The study uncovered a statistically significant difference in the visceral fat area between the DPN and NDPN groups (p = 0.048). Through multivariate logistic regression analysis, the visceral fat area was identified as an independent risk factor for DPN among T2DM patients (OR 1.027; 95% CI 1.004–1.051, p = 0.022). Other significant risk factors included the duration of diabetes and the presence of diabetic retinopathy.Conclusion: The visceral fat area serves as an independent risk factor for DPN in individuals with T2DM. Implementing measures to assess and manage visceral obesity could be vital in the prevention and management of DPN. This underscores the value of technologies such as BIA in clinical and community settings for early intervention.