bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer and Antioxidant Properties of Vernonia amygdalina Delile and Citrus aurantifolia (Christm.) Swingle Juice Extracts: An In Vitro Study
Authors: Ampem Danso Eunice E. , Dotse Eunice , Aning Abigail , Philips Trudy , Hamidu Sherif , Ampofo Janet 
Published: October 2024

Introduction:Vernonia amygdalina Delile (VAD), also known as bitter leaf, is widely utilized in traditional medicine for the treatment of various ailments, including cancer. The presence of bioactive compounds in VAD is believed to be responsible for its characteristic bitterness. In Ghana, it is a common practice to mitigate the bitterness of VAD by combining it with Citrus aurantifolia (Christm.) Swingle (lime) juice extracts, although this method lacks scientific evidence and documentation. Therefore, the antioxidant and anticancer activities of VAD and lime juice extracts (V5) and their combined effects were evaluated in vitro.Method: The antioxidant activity and cytotoxic effects of VAD extracts were determined against Jurkat, MCF‐7, HepG2, and PNT2 cells using the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay to quantify antioxidant activity and the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay to assess cytotoxicity. The statistical analysis of the data was conducted using Microsoft Excel and GraphPad Prism 8.0. Linear regression was employed to determine the correlation between the concentration and the percentage of antioxidant activity, while p values were calculated using Student’s t‐test.Results: The laboratory analysis focused on the extracts V1, V2, V3, V4, and V5. Briefly, V1 and V2 contained equal amounts of saponins and terpenoids. Among these, V2 exhibited the highest free radical scavenging activity, as indicated by an EC50 value of 2.14 ± 0.06 mg/mL. V2 also demonstrated cytotoxicity against the MCF‐7, HepG2, Jurkat, and PNT2 cell lines. On the other hand, V3 and V4 did not show any cytotoxic effects across all tested cell lines. In contrast, V5 was toxic to HepG2 and MCF‐7 cells but had no cytotoxic effect on Jurkat cell lines. V2 exhibited dose‐dependent cytotoxicity (0–1000 μg/mL), with the strongest inhibition observed against Jurkat cells (IC50 value = 96.341 μg/mL) and a selective index of 3.567. The difference in activity between the extracts from different parts of the plant and the extract combined with lime juice was significant (p < 0.05), indicating a synergistic effect of the phytochemicals in both VAD and lime juice.Conclusion: V2 and V5 demonstrated a remarkable antioxidant property, and they are effective in inhibiting cancer cell lines, respectively.
God’s Migrant Caravan: Migration Rhetoric as Missionary Strategy in Acts 7:1-60
Authors: Mata Roberto 
Published: October 2024

Abstract
This article explores Stephen’s speech in Acts 7 as a migration narrative that legitimates the Jesus movement’s mission to the Gentiles. In response to the opponents’ charge that Stephen has spoken against the Law and the Temple, Luke uses Exodus rhetoric—its topoi of Liberation, Wilderness Wanderings, and Promised Land—to redefine the Exodus as an ongoing migration journey. Consequently, Luke transforms the nascent Jesus movement into a migrant caravan and portrays God as a migrant deity who is comfortable accompanying believers in a tent. Reading against the grain, Stephen’s speech contrasts the naivete of the Jesus movement with the zeal of manumitted Diaspora Jews. Thus, as a migration narrative, Stephen’s speech reveals the tensions, hopes, and disenchaments that leaving or returning to one’s home entails.
Spirituality and Support in the Aftermath of Violence: Qualitative Empirical Research among Victims of the War on Drugs in the Philippines
Authors: Dillen Annemie , Papellero Karen , Casteel Amy 
Published: October 2024

Abstract
Since Duterte became the president of the Philippines in 2016 and announced a ‘War against Drugs’, extrajudicial killings were happening frequently, especially in areas where many people living in poverty. This article presents empirical research based on in-depth interviews with women whose partners or sons were killed in the ‘war against drugs’ and with pastoral leaders/volunteers, related to a Catholic parish in the Philippines. The question was how these women experience spirituality and how they describe their needs and expectations from the parish. We explain how discourses about ‘sin’ or ‘spirituality’ are used in various ways in the context of the Philippines: as a legitimation for the extrajudicial killings, or in the context of supporting vulnerable persons in their flourishing. This article helps us to understand how these concepts acquire different meanings depending on the context in which they are used and how they can contribute to the flourishing of persons.
Acting Out
Authors: Blankschaen Kurt , Timmerman Travis 
Published: October 2024

Abstract
When is it morally permissible for performers to portray characters from marginalized groups of which they are not a member? Although this question is philosophically underexplored, it has been commanding increasing attention in the public sphere, especially with respect to straight performers portraying queer characters. While the demand for increasing self-representation from marginalized communities is laudable, we argue that demanding performers to disclose their social identity is, in general, morally counterproductive. We make our case by focusing on recent instances where fans demanded that a performer disclose their sexual orientation, putting vulnerable performers in a harmful trilemma. In short, it will force many to either out themselves against their will, subject themselves to intense public backlash by taking the role without outing themselves, or forgo taking a role they want and at which they would excel. Instead, we propose that performers have a general (epistemic) obligation to learn about what their characters’ corresponding real-world experiences would plausibly be like, representing what they learned in their performances. We will argue that meeting this obligation typically entails learning about the values, broadly construed, of the community in question. If we are right, there is not even a general obligation that performers only take roles that correspond to their own social identity. Just as importantly, there is a strong moral reason not to demand that performers disclose aspects of their social identity in order to take on a role.
Saudi Arabia’s Efforts to Revive the Hijaz Railway from 1925 to 1982
Authors: Al-Salamah Mohammed ibn Abdulrahman 
Published: October 2024

Abstract
This study addresses the attempts by the Kingdom of Saudi Arabia to restore the Hijaz Railway that extended from Damascus to Madinah. The Hijaz Railway was destroyed during the events of the Arab Revolt in 1915; King Abdulaziz attempted to restore it, and so did his sons after him. This study sheds light on the official efforts by the Saudi kings and the discussions held with relevant countries concerning the railway, including the British and French authorities. Moreover, the study reveals the most important meetings and conferences that were held to restore the railway and their outcomes.
Components of home-based palliative and supportive care for adults with heart failure: A scoping review
Authors: Perera Madhurangi , Halahakone Ureni , Senanayake Sameera , Kularatna Sanjeewa , Parsonage William , Yates Patsy , Singh Gursharan K. 
Published: October 2024

Background: Palliative care and supportive care provided in the home for people with heart failure can improve quality of life, caregiver wellbeing and reduce healthcare costs. Identifying components of home-based palliative and supportive care in heart failure is useful to inform tailored care to people with heart failure. Aim: To identify and describe components of home-based palliative and supportive care in adults with heart failure. Design: A scoping review was undertaken in accordance with Joanna Briggs Institute guidelines. The protocol was registered prospectively with the Open Science Framework ( https://doi.org/10.17605/OSF.IO/GHCME ). Data sources: Embase, PubMed, CINAHL and Cochrane databases were searched from inception in May 2023 and re-run in January 2024. Original research focussed on palliative and supportive care in the home setting that included adults diagnosed with heart failure who have not undergone nor awaiting a heart transplant was included. Results: Results were extracted from 13 papers based on eight studies. The findings highlight that nurses supported by a multidisciplinary team, providing symptom management, patient and carer education and discussion of goals of care and advance care planning, facilitates home-based palliative and supportive care for people with heart failure. Conclusion: Ensuring patient and caregiver-centred care supported by a multidisciplinary team is essential to delivering home-based palliative and supportive care for people with heart failure. Further research focussed on the role of digital interventions in home-based palliative and supportive care, the composition of the multidisciplinary team and research which includes individuals across all stages of heart failure is needed.
The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response
Authors: Geng Cheng , Zhang Junxiang , Wu Shixing , Zhang Bolin , Tian Xinxin , A Tigu , Su Hongde , Xu Xinjian 
Published: October 2024

Objective To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP). Methods A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats. Results The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group. Conclusions Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP.
Surface engineering of carbon fiber using microwave micro arcing (MwMA) for enhanced performance of resulting PEEK composites
Authors: Chaudhary Sudhir Kumar , Zafar Sunny , Sharma Satinder 
Published: October 2024

In this work microwave micro arcing (MwMA) has been utilized to engineer the surfaces of carbon fibers (CF) to enhance the interfacial bonding of resulting PEEK based composites. The CF were subjected to MwMA at different power levels ranging from 360 W to 900 W for 60 s to engineer their surfaces. The influence of MwMA on CF at various power levels was analyzed using SEM, contact angle measurement, AFM scans, and XPS study. Subsequently, MwMAed CF reinforced PEEK composite laminates were developed using compression molding. The MwMA on CF increased the surface wetting energy by 38% at 540 W microwave power level. XPS analysis suggested that MwMA at 540 W introduced oxygen containing functional group (C-O and C = O), which are likely responsible for increasing the adhesion between CF and PEEK polymer. The current study suggests that MwMA CF at 540 W showed an increment in tensile strength, flexural strength, interlaminar shear strength, and impact strength nearly by 22%, 61%, 28%, and 98% respectively. The MwMA method is novel method to improve the surface properties of carbon fibers and shows the potential use in structural applications.
Ameliorative Potency of Iridoid Glucoside Compound Catalpol on Inhibiting NF-κB-mediated Inflammation in Allergic Rhinitis-induced Mice
Authors: Wang Haiting , Wang Jing 
Published: October 2024

Background Over time, the prevalence of allergic rhinitis (AR) has surged due to various risk factors, notably attributed to global urbanization, rendering heightened levels of pollutants, including traffic-related emissions and particulate matter. About 25% of the global children population and 40% of the adult population were reported with AR. Even though AR is recognized as a systemic inflammatory disease, it often results in diverse other comorbidities, such as dermatitis, sinusitis, conjunctivitis, and otitis, requiring extensive and expensive treatment. Objectives We assessed the effectiveness of iridoid glucoside catalpol against AR in a mouse model. Catalpol is recommended in traditional Chinese medicine to treat diverse acute and chronic diseases. Materials and Methods AR was induced in mice with an ovalbumin-sensitized AR model and treated with 10 and 20 mg of catalpol. Nasal severity scoring was performed to confirm the AR induction in mice. Allergic mediators immunoglobulin E (IgE) and histamine were quantified in the serum to assess the anti-allergic response of catalpol. In nasal lavage fluid (NALF), the inflammatory mediators IgE Ab, prostaglandin D2, leukotriene C4, eosinophil cationic protein (ECP), and pro-inflammatory cytokines were measured to analyze the anti-inflammatory potency of catalpol. The binding capacity of nuclear factor-kappa B (NF-κB) to DNA was evaluated to assess the catalpol inhibitory potency against NF-κB-mediated inflammation in AR mice. To confirm the ameliorative potency of catalpol in AR mice, a histopathological analysis of nasal mucosa was performed. Results Catalpol treatment significantly decreased the nasal symptoms and reduced the allergic mediators in the serum of experimental animals. It effectively inhibited the synthesis of inflammatory mediators, ECP, and pro-inflammatory cytokines in the NALF, and also suppressed the NF-κB DNA-binding activity in AR mice. The decrease in ciliary loss, goblet cells, eosinophil infiltration, and vascular congestion observed with our nasal mucosa histopathological analysis confirmed the ameliorative potency of catalpol. Conclusion Our findings have proven catalpol inhibits NF-κB-mediated inflammatory response in AR mice. With further analysis, a potent natural compound, catalpol, can be formulated as a drug to treat AR.
Impact of COVID-19 Pandemic on Caregivers of Children with Neurodevelopmental Disabilities: A Qualitative Study
Authors: Samyuktha V N , Grace Hannah , Kattula Dheeraj , Oommen Samuel Philip 
Published: October 2024

Background/Aim: It is well known that caregivers of children with neurodevelopmental disabilities (NDD) face challenges. These challenges increased further due to the coronavirus disease 2019 (COVID-19) pandemic and the related restrictions. There was very little data from India on these challenges. This study was done with the primary aim to gain insights about the challenges faced by parents of children with NDD through their personal stories. Methods: Participants were recruited using purposive sampling method and semi-structured interviews were conducted through a telephone or in person. Data saturation was achieved by the sixth participant and 2 more interviews were performed for further confirmation. Interviews were transcribed, and a 7-step Colaizzi’s phenomenological method was used to identify different themes. Results: The impact of COVID-19 on caregivers of children with NDD can be summarized into 4 broad themes. First, there were challenges related to “therapy” which included closure of day-care centers and schools, inaccessibility to professionals, and disruption in home-based learning. Second, there were “child” related challenges which included inappropriate behaviors. Third, there were “family” challenges which included misunderstandings between parents and difficulties in adhering to family routines. Lastly, there were “personal” challenges related to physical and psychological health. Conclusion: The personal stories of caregivers of children with NDD highlight the pressing need to provide appropriate support and formulate holistic models to enhance well-being of caregivers during difficult periods.
ML-powered Internet of Medical Things (MLIoMT) Structure for Heart Disease Prediction
Authors: Mulani Altaf O. , Sardey Mohini P. , Kinage Kishor , Salunkhe Shweta Sadanand , Fegade Tanuja , Fegade Poonam Girish 
Published: October 2024

Background ML-powered Internet of Medical Things (MLIoMT) is a burgeoning framework poised to transform healthcare, particularly in the timely identification of heart disease. Objectives This article proposes an innovative MLIoMT structure aimed at leveraging machine learning (ML) algorithms for heart disease detection. Materials and Methods Through the integration of wearable sensors, mobile applications, cloud computing, and advanced ML techniques, MLIoMT enables continuous monitoring of vital signs and cardiac health indicators in real time. By analyzing this data stream, abnormalities indicative of heart disease can be detected early, facilitating timely intervention and personalized healthcare recommendations. The MLIoMT framework employs diverse ML methods, such as deep learning and ensemble techniques to enhance the accuracy and reliability of heart disease prediction models. Results The proposed structure holds promise for revolutionizing preventive healthcare, enabling proactive management of cardiac health, and ultimately reducing the burden of heart disease. Results in terms of accuracy, precision, recall and F1 score show that the proposed system has better performance and efficiency. Conclusion Overall, MLIoMT represents a significant advancement in healthcare technology, with the potential to improve patient outcomes and enhance overall quality of life.
Women’s Attitudes toward Family Planning in the Postpartum Period and Affecting Factors: Turkiye Sample
Authors: Bilge Çiğdem , Kaydırak Meltem , Altınsoy Büşra , Yakıt Ak Eda , Öztürk Sevdiye 
Published: October 2024

Introduction: Despite declining birth rates and improvements in maternal health care, the number of unwanted pregnancies and unwanted births in Turkiye remains high. The aim of this study was to determine women’s attitudes and preferences regarding family planning and the factors influencing them in the postpartum period. Method: A descriptive and correlational study was carried out. Data were collected using a personal information form and the Family Planning Attitude Scale in the online environment. Results: According to the results of this study, the number of women who did not receive family planning counseling during pregnancy (42.6%) and the postpartum period (36.9%) was considerably high. Women’s family planning attitudes change positively when they move from the east to the west of Turkiye. Discussion: According to the results of the study, it was observed that a person’s education, economic status, and cultural values  are effective in family planning method selection and family planning attitude.
Perioperative anaesthetic complications in healthy cats undergoing anaesthesia for neutering in first opinion practice
Authors: Brown Jenny F , Murison Pamela J 
Published: October 2024

Objectives The aim of the present study was to identify the incidence of common perioperative anaesthetic complications in cats undergoing anaesthesia for neutering in three UK first opinion practices. Methods A retrospective anaesthetic record analysis was performed on cats anaesthetised for neutering at practices 1 and 2 between 9 December 2017 and 2 February 2021 and practice 3 between 9 March 2020 and 7 January 2021. A search of the practice management system identified all cats that had undergone neutering in the selected timeframe. Data from 1019 cats were included in the study. Information relating to patient characteristics and data from the anaesthesia session were extracted from electronic patient records and anaesthesia record charts and entered into an Excel spreadsheet. A definition of the complications was created after reviewing the literature and their incidence determined from the data set. Comparisons between different groups of cats in the study were made using a χ2 test for homogeneity or Fisher’s exact tests to identify factors associated with increased incidence of complications. Results The anaesthetic-related mortality was 1/1019 (0.10%). The most common complications were hypotension (22.6%), bradycardia (16.7%) and hypothermia (13.8%). Less common complications were hypocapnia (12.7%), hypercapnia (8.7%), tachycardia (6.6%), apnoea (3.1%), hyperthermia (1.7%), hypertension (1.4%), endotracheal tube obstruction (1.1%), hypoxia (0.3%), undesirable recovery (0.6%) and cardiac arrhythmia (0.2%). Factors associated with increased risk of hypotension were acepromazine pre-anaesthetic medication, higher maximum isoflurane dose, longer anaesthetic duration and lower body weight. Factors associated with increased risk of bradycardia were medetomidine pre-anaesthetic medication, longer anaesthetic duration and higher body weight. Factors associated with increased risk of hypothermia were higher maximum isoflurane dose, increased anaesthetic duration and lower body weight. Conclusions and relevance This study showed that anaesthetic complications were frequently observed, with complications documented in 53.4% of the cats in the study. The information in this study may help to guide prioritisation of monitoring in feline anaesthesia.
Prospective Association Between Tobacco Use and at-Risk Alcohol Consumption Among Swedish Adolescents: Outlining the Influence of Tobacco Product, Frequency of Use and Gender in the LoRDIA Cohort
Authors: Andersson Johanna , Berglund Kristina , Irmel Robin , Adermark Louise 
Published: October 2024

Introduction: Tobacco use is not only a major risk factor for morbidity and mortality but also associated with alcohol misuse. While personality traits may be driving this association, the psychoactive component of tobacco, nicotine, may also be a major risk factor. The aim with this study was to further assess the prospective association between tobacco use and alcohol consumption, with special emphasis on the role of the tobacco product used (cigarettes and Swedish snus), frequency of use, and gender. Methods: Data was extracted from the prospective cohort Longitudinal Research on Development In Adolescence (LoRDIA), following Swedish adolescents over four waves (∼13 to 17 years of age). Tobacco use was reported with respect to product used and frequency of use, while alcohol use was assessed using AUDIT-C, as well as frequency of use within the last year. Results: Use of tobacco, independent of product used and gender, was associated with increased alcohol consumption. High frequency of use and dual use strengthened to association. Individuals initiating tobacco use during the study period progressively increased their frequency of alcohol consumption compared to non-users during consecutive waves. Furthermore, tobacco use was associated with at-risk consumption of alcohol at follow up, even when adjusting for previous alcohol inebriation, socioeconomical factors, gender and novelty seeking. Conclusions: The data presented here suggests that nicotine use during adolescence, and especially dual use, is a major risk factor for future hazardous alcohol intake. This finding is especially important considering the escalated use of nicotine pouches, which in many ways resembles Swedish snus. From a public health perspective, preventive measures and policies designed to counteract all forms of nicotine use among youths is warranted.