bluuebunny/crossref_metadata_2025_split huggingface dataset:
Permeability and Compressive Strength of Pervious Cement Concrete with Small Size Aggregates
Authors: Chen Bo , Zhang Xiaochuang , Wang Xiongfeng , Zhang Feng , Lv Lele , Bai Yin , Ma Haoda 
Published: December 2024

AbstractTo prepare high-performance pervious concrete with excellent mechanical properties and permeability, an orthogonal test method is used to investigate the effects of water-to-binder (W/B) ratio, grading of small size aggregates, and target continuous void content on the mechanical properties and permeability of pervious concrete. The results show that the W/B ratio and grading of small-size aggregates have negligible effects on compressive strength and permeability. The target continuous void content is the key parameter in determining the permeability of concrete. The compressive strength must be controlled within a certain range to ensure a certain range of permeability. Only one permeability parameter is suitable for pervious concrete mix design.
Seismic Performance of a Prefabricated Pre-embedded Steel–Concrete Column Base Connection
Authors: Gao Hongyuan , Liu Jie , Liu Changsha , Xie Qun , Gao Jinpeng , Liu Kecheng , Zhang Gang 
Published: December 2024

AbstractA prefabricated pre-embedded steel–concrete column base was presented which aimed to be applied in a petroleum pipeline gallery and three full-scale specimens were tested under quasi-static cyclic loading to investigate the seismic performance. Failure patterns, hysteretic characteristics, skeleton curves, displacement ductility, and stiffness of columns have been studied. The results showed that concrete spalling failure in the cast-in-place connection part of all specimens occurred and there was no visible crack in the column. The hysteretic curves of specimens indicated relatively good energy dissipation performance. The additional anchor rebar can effectively enhance the connection between the precast column and cast-in-place concrete. The strength along the strong axis and the weak axis was similar based on the comparison of seismic parameters. The specimens still maintained relatively high residual strength even after cast-in-place concrete failure which presented a potential possibility of engineering application in petroleum pipeline gallery.
Research on Bearing Capacity Size Effect of RC Frame Considering Material Size Effect
Authors: Zhou Hongyu , Han Shuai , Zhou Yun , Zhao Xiaohua 
Published: December 2024

AbstractThe size effect correction formulas of peak strength and peak strain of concrete materials are summarized by using regression analysis theory and Bažant size effect law. The finite element software Seismostruct is used to simulate the unidirectional nappe of three groups of plane frame structures with different sizes of modified materials, and the simulation results are compared with the experimental results. The results show that the bearing capacity of the structure decreases with the increase of size, and the simulation results considering the size effect correction are closer to the test results, so it is suggested that the material size effect correction should be taken into account in the structural design analysis.
Experimental and Analyses on the Deterioration of Mechanical Properties of Transport Bridges Based on Hot and Humid Marine Environment
Authors: Chen Yunkai , Deng Peng , Wang Yao 
Published: December 2024

AbstractThe mechanical properties of in-service concrete bridges in the sea are subject to accelerated deterioration due to the harsh environment in which they are located, which poses a serious challenge to bridge transportation work. Therefore, it is necessary to analyse and study the mechanical property evolution of lightweight aggregate concrete in the marine environment and transport engineering design. In order to study the mechanical property degradation law of nano-modified ceramic concrete under the action of dry and wet cycles and temperature, tests were conducted on nano-modified ceramic concrete specimens at different temperatures (30 °C, 40 °C, 50 °C) and different numbers of dry and wet cycles (15, 45, 75), respectively. The test results showed that with the increase of the number of cycles, the change of compressive strength showed a typical three-phase law, while the split tensile strength showed the law of deterioration, strengthening, and then deterioration. With the increase of temperature, the compressive strength increases and then decreases, while the splitting tensile strength decreases continuously, and the decrease is greater. Under the combined effect of the two factors, three damage modes of compressive and split tensile were analysed. Finally, the uniaxial compression constitutive model and the formula for the attenuation change of mechanical properties of nano-modified ceramic concrete were fitted based on the test data under dry and wet cycles and temperature.
Modelling the Mechanical Behaviour of the RC Pipe Pile with Construction-Induced Damage and Cracks
Authors: Yu Weixin , Wang Xiaohui 
Published: December 2024

AbstractDuring the construction of the high-piled wharf, cracks may be induced in the top zone of the pre-stressed high-strength concrete pipe pile due to the high-frequency hitting. In this paper, the influence of the construction-induced damage and cracks on the mechanical properties of prestressed reinforced concrete (RC) pipe piles is studied. Finite element analysis is used to simulate the mechanical behaviour of the RC pipe piles with construction-induced damage and the corresponding ultimate bearing capacity of the damaged RC piles is predicted. Influence of different lengths of the construction-induced damage zone and maximum crack widths within the damage zone on the mechanical behaviour of the RC pipe pile is discussed. Results indicate that, the ultimate bearing capacity of the RC pipe piles with construction-induced damage in the top zone of the pile is reduced due to the damage. The failure of the RC pipe piles with construction-induced damage may occur at both the bottom and middle part of the pile for longer damage length and wider maximum crack width.
Research on Point Cloud Reconstruction of Pumping and Storage Construction Site Under Ground 3D Laser Scanning Technology
Authors: Cao Feng , Ying Pengtao , Zhong Jianxu , Han Jishuang 
Published: December 2024

AbstractThe current point cloud reconstruction matrix of the pumping and storage construction site is generally set to be unidirectional, and the efficiency of point cloud reconstruction is low, which leads to the prolongation of point cloud reconstruction time. Therefore, the design and verification of point cloud reconstruction method for pumping and storage construction site underground 3D laser scanning technology are proposed. According to the actual point cloud reconstruction requirements and standards, the 3D point cloud primitive library is constructed first, and the multi-step method is adopted to improve the efficiency of point cloud reconstruction. The multi-step point cloud reconstruction matrix is designed. Based on this, the point cloud reconstruction model of the ground 3D laser scanning and storage construction site is established, and the point cloud reconstruction processing is realized by building topology matching. The test results show that after the measurement and analysis of five areas, the final point cloud reconstruction time of the unit project is well controlled below 0.25 s, which indicates that, with the assistance and support of the ground 3D laser scanning technology, the current point cloud reconstruction for the G pumping construction project is more effective, more targeted and it has a larger coverage of point cloud reconstruction, which has practical application value.
Research of Monitor System for Water Lock Gate Based on Digital Twin Technology
Authors: Liu Qiyong , Li Ming 
Published: December 2024

AbstractAs climate change becomes more severe, droughts and floods are causing increasing losses to people’s lives and property. How to fully utilize modern computer technology, communication technology, artificial intelligence, and 3D simulation technology to build a comprehensive control system for water lock gates of a whole river has become a key research focus. The ultimate goal is to achieve remote real-time monitoring of changes in the hydrological conditions of the river basin and precise control of water gates to regulate water resource utilization and reduce disasters. This article introduces a digital twin system for comprehensive control of water gates. It will model buildings and equipment into 3D models, and convert measurement data obtained from sensors into real-time measurement data into 3D numerical model mapping data, reflecting the real-time status of buildings and equipment. Based on real-time data and HYDRONETS models, disaster prediction will be carried out to achieve precise regulation of water resources and reduce disaster losses.
Research on the Application of UAV Photogrammetry Technology in Highway Slope Deformation Identification
Authors: Yan Xin , Yu Yiqaing , Zhan Wei , Hu Zhi , Xiao Danqiang , Wu Jianjun 
Published: December 2024

AbstractThe safety of highway slope is always one of the key works of highway management and maintenance department. However, the current highway slope maintenance inspection is mainly manual inspection, monitoring coverage is very low, only a few slopes installed automatic monitoring equipment. Due to the high cost and complex installation of automatic monitoring equipment, how to carry out efficient deformation inspection of highway slope is an important direction of highway maintenance research. Thanks to the rapid development of UAV close-range photogrammetry technology, this paper proposes to use UAV close-range photogrammetry technology to identify highway slope deformation. It mainly shoots UAV aerial survey images and obtains three-dimensional point cloud data of highway slope time series through data processing processes such as encryption and adopts ICP algorithm to register multi-phase point clouds. The change of three-dimensional point cloud is obtained by using point cloud difference calculation, so that the displacement and deformation characteristics of highway side slope are obtained. Through the application of field cases, the study verified the effectiveness of UAV close-range photogrammetry technology in highway slope deformation identification, with an accuracy of about cm level. The proposal and promotion of this technology can provide data support for subsequent highway slope protection and management and is of great significance for improving the quality and work efficiency of highway slope maintenance and management.
Synthesis and Property Analysis of a Novel Epoxy Composite Curing Agent Based on Soft Soil Curing
Authors: Cui Shengchao , Wang Guangzheng , Liu Shu , Yan Xintong , Fan Ming 
Published: December 2024

AbstractTo meet the demand for shore-based engineering, engineering rescue and traffic emergency support in different complex conditions, a new low-temperature fast solidifier for epoxy resin was synthesized by Mannich reaction using thiourea, polyamine, formaldehyde, phenol and benzyl alcohol. The performance of the curing agent was investigated based on raw material ratio, reaction temperature and reaction time. Moreover, the curing time, amine value, viscosity and infrared spectrum were tested. It was compounded with other highly active curing agents and resins. The compressive strength of the cured sea sand was used as the index to determine the formula of a new epoxy composite used for the rapid curing of sand under low temperature or saturated water conditions. The results showed that the optimal synthesis conditions of the curing agent were as follows: the molar ratio of thiourea, diethylenetriamine, formaldehyde, phenol and benzyl alcohol is 1.2: 1.3: 1: 0.4: 1. The addition of a small amount of accelerator DMP-30 could effectively improve the curing reaction speed and reduce the curing time. These epoxy composites could effectively solidify the sea sand and improve its mechanical properties, which provides important utilization value for coastal engineering construction in the cold season or wet rainy season.
Example of Seismic Performance-based Design of Highway Monitoring Building in High Seismic Intensity Area
Authors: Wang Yuzheng 
Published: December 2024

AbstractWith the technological development of resilient city and intelligent transportation, since the terminal equipment of real-time monitoring and safety monitoring system for lifeline projects is usually set up in highway monitoring halls, more and more highway monitoring centers in China's seismic high intensity areas assume the important function of emergency command centers after earthquakes. In order to ensure that the monitoring and surveillance equipment can operate normally during an earthquake, this paper puts forward a proposal to adopt seismic isolation technology for the monitoring center, and gives the performance objectives and quantitative indexes based on performance-based seismic design. Through the finite element numerical simulation and nonlinear time course analysis of engineering examples, the results show that: the inter-story shear force, inter-story displacement, floor acceleration and other dynamic response indexes are greatly reduced compared with the pre-seismic isolation, which can realize the setup goal of monitoring and controlling the building for uninterrupted use in earthquakes and assuming the function of emergency rescue and command, and effectively verifies the reasonableness of the performance goals set in this paper. At the same time, from the perspective of the whole life cycle of building and equipment maintenance, the use of seismic isolation design can also save costs. The research content of this paper provides a theoretical basis for the feasibility of promoting seismic isolation structures in the field of highway monitoring buildings.
Atopische Dermatitis und Diabetes mellitus – Gibt es Zusammenhänge?
Authors: Sendrea Adelina-Maria , Salavastru Carmen Maria 
Published: December 2024

Zusammenfassung
Hintergrund
Atopische Dermatitis und Diabetes mellitus sind chronische, immunvermittelte, entzündliche Erkrankungen, die die Lebensqualität der Patienten erheblich beeinträchtigen und zudem eine beträchtliche sozioökonomische Belastung darstellen. Trotz intensiver Forschung in den letzten Jahrzehnten bleibt der mögliche Zusammenhang zwischen diesen beiden medizinischen Zuständen aufgrund spärlicher und manchmal widersprüchlicher Daten ein umstrittenes Thema. Dennoch beruht die potenzielle Verbindung zwischen ihnen auf einigen anerkannten gemeinsamen pathophysiologischen Merkmalen.

Ziele
Ein möglicher Zusammenhang zwischen atopischer Dermatitis und Diabetes mellitus soll dargestellt und bewertet werden.

Material und Methoden
Wir führten eine Literaturrecherche zum potenziellen Zusammenhang zwischen atopischer Dermatitis und Diabetes mellitus durch.

Ergebnisse
Mehrere Studien haben eine Korrelation zwischen atopischer Dermatitis und Diabetes mellitus Typ 1 oder Typ 2 festgestellt. Andere Studien zeigten jedoch keinen Zusammenhang zwischen diesen beiden Erkrankungen oder deuteten sogar darauf hin, dass atopische Dermatitis das Risiko für die Entwicklung von Diabetes mellitus bei bestimmten Patienten verringern könnte. Darüber hinaus weisen diese beiden chronischen Erkrankungen auch bestimmte klinische Merkmale auf, die auf eine mögliche Korrelation hindeuten. Derzeit gibt es jedoch keinen eindeutigen wissenschaftlichen Beweis für einen signifikant positiven Zusammenhang zwischen atopischer Dermatitis und Diabetes mellitus, was v. a. auf das Fehlen umfangreicher und vielfältiger demografischer Studien zurückzuführen ist.

Schlussfolgerungen
Ärzte sollten sich dieser potenziellen Korrelation sowohl bei Erwachsenen als auch bei pädiatrischen Patienten bewusst sein und die Bedeutung eines multidisziplinären Ansatzes für das Management der atopischen Dermatitis berücksichtigen. Weitere Untersuchungen sind erforderlich, um mögliche Zusammenhänge zwischen atopischer Dermatitis und Diabetes mellitus in spezifischen Bevölkerungsgruppen zu bestimmen.
Particle-resolved simulation of the pyrolysis process of a single plastic particle
Authors: Zhang Feichi , Tavakkol Salar , Galeazzo Flavio C. C. , Stapf Dieter 
Published: December 2024

Abstract
Particle-resolved simulations have been performed to study the pyrolysis process of a high-density polyethylene (HDPE) particle in an inert hot nitrogen flow. The simulations resolve the velocity and temperature boundary layers around the particle, as well as the gradients of temperature and concentration within the particle. The objective of this work is to gain an in-depth understanding of the effect of particle morphology-specifically, the particle size and shape-on the interplay between heat transfer and pyrolysis progress, as well as to assess the applicable particle size when using the Lagrangian concept for simulating plastic pyrolysis. In all simulation cases, the pyrolysis reaction is initiated at the external surface of the particle, where the particle is heated the fastest. The reaction front propagates inward toward the core of the particle until it is fully pyrolyzed. For particle diameters larger than 4 mm, distinct temperature gradients within the particle can be detected, leading to a temperature difference of more than 10 K between the core and the external surface of the plastic particle. In this case, the Lagrangian simulations yield a considerably slower conversion compared with the particle-resolved simulations. Moreover, the cylindrical particle in longitudinal flow has been found to be pyrolyzed more slowly compared with the spherical and shell-shaped particles, which is attributed to the enhanced heat transfer conditions for the cylindrical particle. The results reveal the importance of considering particle morphology when modeling plastic pyrolysis. In addition, the Lagrangian approach, which assumes particle homogeneity, is only applicable for particle diameters smaller than 2 mm when modeling plastic pyrolysis.
High interobserver variability of PTEN immunohistochemistry defining PTEN status in low- to intermediate-risk prostate cancer: results of the first German ring trial
Authors: Hommerding Oliver , Bernhardt Marit , Kreft Tobias , Scherping Anna , Abbas Mahmoud , Baretton Gustavo , Bräsen Jan Hinrich , Breyer Johannes , Darr Christopher , Dressler Franz Friedrich , Ellinger Jörg , Erber Ramona , Esposito Irene , Hartmann Arndt , Hartmann Wolfgang , Heitplatz Barbara , Kreipe Hans , Lafos Marcel , Linxweiler Johannes , Lopez-Cotarelo Cristina , Sailer Verena , Reis Henning , Saar Matthias , Schildhaus Hans-Ulrich , Schlack Katrin , Schmid Matthias , Seidl Maximilian , Semjonow Axel , Sommer Ulrich , Stahl Phillip Rolf , Tischler Verena , Weber Florian , Wulf Anna-Lena , Wullich Bernd , Kristiansen Glen 
Published: December 2024

AbstractThe prognostication of individual disease trajectory and selection of optimal therapy in patients with localized, low-grade prostate cancer often presents significant difficulty. The phosphatase and tensin homolog on chromosome 10 (PTEN) has emerged as a potential novel biomarker in this clinical context, based on its demonstrated prognostic significance in multiple retrospective studies. Incorporation into standard clinical practice necessitates exceptional diagnostic accuracy, and PTEN’s binary readout—retention or loss—suggests its suitability as a biomarker. This multi-institutional ring trial aimed to validate the diagnostic precision of PTEN immunohistochemistry in localized, low- to intermediate-risk prostate cancer, across ten university pathology institutes in Germany. The trial incorporated 90 cases of patients diagnosed with acinar adenocarcinoma of the prostate of grade groups 1 (n = 8, 8.9%) and 2 (n = 82, 91.1%) post-radical prostatectomy. Remarkably, the interpretation of PTEN immunohistochemistry displayed substantial variation (12.5–51.2% PTEN loss rates) within an identical cohort of prostate cancer. Fluorescence in situ hybridization analysis demonstrated PTEN hemizygous deletions in 5.5% (5/90) of cases. All cases with hemizygous deletions presented a distinct loss of PTEN expression by immunohistochemistry and were unanimously identified as PTEN loss by all participants (sensitivity 100%). However, negative (loss) immunohistochemistry was relatively non-specific for an underlying genomic deletion. Improved inter-observer agreement was observed in a subsequent ring trial. Finally, we identify S473-pAKT immunohistochemistry as a useful marker in equivocal cases. In summary, this multi-institutional ring trial illustrates surprisingly heterogeneous outcomes in defining PTEN status by immunohistochemistry.
i-WASP—Intelligent and Wireless Technologies for Automatically Generated Shift Protocols in Conventional Tunnelling
Authors: Shaw Clemens , Villeneuve Marlene , Dengg Fabian , Gruber Pascal , Thienert Christian , Klaproth Christoph , Gutberlet Lara , Ungers Claudia , Bittmann Harald , Auderer Stefan , Staggl Lukas 
Published: December 2024

AbstractThe research project i‑WASP, a collaboration of specialized German and Austrian companies and research institutions, looks at the question of how complex processes on a conventional tunneling construction site can be automatically recorded, analyzed, and classified through the development of innovative solutions for data acquisition, transmission, and processing. A trained artificial intelligence will be able to automatically produce accurate minute diagrams based on accelerometer and positional data gathered from the construction machines.
Efficacy and safety of mosunetuzumab monotherapy for Japanese patients with relapsed/refractory follicular lymphoma: FLMOON-1
Authors: Goto Hideki , Kumode Takahiro , Mishima Yuko , Kataoka Keisuke , Ogawa Yoshiaki , Kanemura Nobuhiro , Shimada Kazuyuki , Uchida Toshiki , Kuroe Yukano , Kawasaki Atsuko , Sato Jotaro , Teshima Takanori 
Published: December 2024

Abstract

Background
In a global phase I/II study (GO29781; NCT02500407), single-agent mosunetuzumab had a manageable safety profile and induced durable complete responses in patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma, including in patients with R/R follicular lymphoma (FL). In this analysis, the efficacy and safety of mosunetuzumab monotherapy were evaluated in an expansion cohort, FLMOON-1, in Japanese patients with R/R FL who had received  ≥ 2 prior lines of therapy in a phase I study (JO40295, jRCT2080223801).

Methods
Mosunetuzumab was administered intravenously at the recommended phase II dose (with cycle 1 step-up dosing) for eight cycles or up to 17 cycles, or until disease progression or unacceptable toxicity. The pre-specified primary endpoint was Independent Review Facility (IRF)-assessed complete response rate (CRR; as best overall response). Secondary objectives included investigator (INV)-assessed CRR, INV- and IRF-assessed objective response rate (ORR), and safety.

Results
At the data cutoff (October 13, 2023), 19 patients (median age 72 years) were evaluated. The IRF-assessed CRR and ORR were 68.4% and 78.9%, respectively; the INV-assessed CRR and ORR were 63.2% and 84.2%, respectively. Grade 3–4 adverse events (AEs) were observed in 89.5% of patients, with a low incidence of AEs leading to mosunetuzumab discontinuation (10.5%) and one fatal AE unrelated to mosunetuzumab. Cytokine release syndrome occurred in 47.4% of patients and were mostly Grade 1 in severity.

Conclusion
These findings indicate mosunetuzumab has a consistent efficacy and manageable safety profile in Japanese patients with R/R FL compared with previously reported data from the global phase I/II study.