bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pica and the radiologist – beyond the radiology report … digging deeper
Authors: Kalgaonkar Sameer R , Ramakantan Ravi 
Published: October 2018

AbstractPica is a psychological disorder of intentional and craving consumption of non-nutritive substances over a period of time. This is seen at an age when such a behavior is developmentally inappropriate. Substances such as wall paint, soil, hair, and feces have been reported as being consumed. Complications of this condition may range from being self-limiting to life-threatening. Radiological examinations play a crucial role in the diagnosis and management of this condition. We present a case of a 9-year-old boy who presented with chronic abdominal pain with history of persistent consumption of pencil erasers. Abdominal radiographs showed radio-opaque foreign bodies, and etiological diagnosis was made when the radiologist obtained a detailed history from the patient's mother. We also discuss the radiographic evaluation of the pencil eraser and the reason why it is densely radio-opaque.
Interventional radiology-operated endoscopy using the LithoVue disposable endoscope: Approach, technical success, clinical outcomes, and complications
Authors: Patel Nishant , Chick Jeffrey Forris Beecham , Gemmete Joseph , Pampati Rudra , Johnson Evan , Srinivasa Ravi 
Published: October 2018

Abstract
Purpose: To report the approach, technical success, clinical outcomes, and complications of interventional radiology-operated endoscopy using the LithoVue disposable endoscope. Materials and Methods: 12 patients, 6 (50%) males and 6 (50%) females, underwent interventional radiology-operated endoscopy using the LithoVue disposable endoscope between April 2016 and August 2017. Presenting complaint, reason for endoscopic evaluation, technical success, clinical success, procedure time, fluoroscopy time, hospital length of stay, and complications were recorded. Results: Interventional radiology-operated endoscopy using the LithoVue disposable endoscope was used in 8 (67%) biliary, 2 (16.5%) urologic, and 2 (16.5%) gastrointestinal procedures. Five (42%) patients required endoscopy to locate an ostium that could not be cannulated under fluoroscopy. Five (42%) patients had a biliary-enteric anastomosis with postoperative anatomy of the bowel which precluded endoscopic retrograde cholangiopancreatography and underwent endoscopy for removal of calculi. One (8%) patient underwent treatment of a stricture and one (8%) underwent biopsy. Technical success was 92% (11/12). Clinical success was 83% (10/12). Two complications, a perinephric hematoma and sepsis, occurred. Conclusion: Disposable endoscopes, including the LithoVue, may be used in a variety of procedures to improve patient care and limit fluoroscopy.
Endovascular management of a large retroperitoneal haemorrhage resulting from dual testicular and intra-renal arterial injury after renal biopsy
Authors: Ahmed Munawwar , Keshava Shyamkumar Nidugala , Moses Vinu , Valson Anna T 
Published: October 2018

Abstract
Percutaneous renal biopsy is a minimally invasive procedure in the work up of a chronic kidney disease patient. However, it is not free from the complications. Hematuria and abdominal haemorrhage due to intra-renal artery injury are the common complications. We report and discuss the management of a rare case of retroperitoneal haemorrhage resulting from dual arterial injury involving left testicular artery and intra-renal artery.
Exploring symptom expressions according to different age groups in fibromyalgia: a cross-sectional study
Authors: Keskindag Buse 
Published: October 2018

BackgroundFibromyalgia syndrome is a chronic musculoskeletal disorder which mostly affects women. This study investigates whether the prediction of self-report based fatigue, stress, everyday memory and impact (the most affected components of health status, i.e., physical impairment, feeling good, doing work, pain, anxiety, etc.) differ between younger patients and older patients with fibromyalgia.Participants and procedureThe current study included a community-based sample of 1,205 participants who had been diagnosed with fibromyalgia according to the American College of Rheumatology criteria. Participants were categorized into four age groups (30-39, 40-49, 50-59 and 60-90). Binary logistic regression was used to analyze whether there were differences between the youngest patients (30-39) and the older patients (40-49, 50-59 and 60-90) in the prediction of each variable (i.e., fatigue, impact, stress and memory deficits).ResultsWhen the youngest patients’ scores were compared with the older patients’ scores, there was at least one significant result for each dependent variable (i.e., fatigue, impact, perceived stress and everyday memory). The youngest patients reported more fatigue than the 50-59 age group and a greater impact than both the 40-49 and 50-59 age groups; furthermore, they exhibited lower everyday memory function than the 40-49 and 50-59 age groups. However, the youngest patients reported less perceived stress than the elderly patients (60-90).ConclusionsThe current findings suggest that the youngest patients generally report having more symptoms than older patients in terms of fibromyalgia. There have been a limited number of studies examining symptom expressions in different age groups. Further research should clarify the differences in expression of symptoms between age groups by investigating coping skills and illness perceptions in fibromyalgia.
Positive orientation as a predictor of hedonicwell-being: mediating role of the self-concept
Authors: Laskowska Agnieszka Anna , Jankowski Tomasz , Oleś Piotr , Miciuk Łukasz 
Published: October 2018

BackgroundPositive orientation (PO) is a hidden variable explaining a tendency to formulate global evaluations regarding one’s self, life and the future. It is inherited to a large degree and it could be considered a common base for numerous aspects of subjective well-being. The self-concept, in turn, is a basic adaptation formed during individual experiences that is responsible for adjustment. The primary aim of the current study was to verify hypotheses about the significant relationship between PO and a ‘core self’ (high self-concept clarity, low self-esteem contingency, low self-rumination), as well as the meditational role of the ‘core self’ in the relation between PO and hedonic balance.Participants and procedureA group of 200 participants completed several measures referring to PO, self-concept and emotions.ResultsThe canonical correlation analysis revealed PO to be a strong predictor of the adaptive features of the self-concept. Moreover, the tested models suggest that (1) self-concept clarity is a significant mediator between PO and hedonic balance, and (2) PO directly predicts only self-concept clarity, whereas its relations with self-esteem contingency and rumination are mediated by the self-knowledge structure.ConclusionsThese findings indicate that PO is an important and independent factor enhancing adaptive features of the self-concept structure as well as well-being.
In quest of the longest-lasting and most annoying pain for patients and for dentists. Quantitative and qualitative characteristics of temporomandibular myofascial pain dysfunction syndrome – a questionnaire study
Authors: Biegańska-Banaś Joanna M. , Gierowski Józef K. , Ferendiuk Ewa , Pihut Małgorzata , Adamczyk Katarzyna 
Published: October 2018

BackgroundDysfunctions in the face, due to the psychological importance of the structures in the face and head, have long been a subject of interest for researchers exploring issues concerning health-related quality of life. The surprising results of previous clinical trials for myofascial pain dysfunction syndrome of the temporomandibular joints encouraged the present authors to plan a study focused on obtaining systematic knowledge of the issue.Participants and procedureThe study included 26 patients of the Masticatory System Disorders Laboratory of the Dental Prosthetic Clinic at the Jagiellonian University Medical College diagnosed with the painful form of muscle-related functional masticatory organ disorders. The study was part of a larger research project. The data to be analysed for this article was obtained in the course of a single questionnaire survey conducted prior to the start of the treatment process.ResultsThe results showed the quantitative characteristics of pain experiences in the clinical group, observed in the context of the circadian dynamics, psychophysical factors, and the location of pain, as well as their quality characteristics. The analyses showed negative covariances of the quality of life perceived by patients and the length of periods without pain, pain intensifying factors, and emotional image of pain. The strongest pain experienced by the patients negatively correlated with the quality of life related to the sphere of physical pain and mental distress, whereas the weakest pain correlated with the quality of life related to the social sphere. The lower quality of life occurred together with the frontal, zygomatic, mental, parotideomasseteric, and occipital region.ConclusionsIt is necessary to further analyse the issue on a larger sample in order to explain and clarify the obtained results.
Statistical study of ULF waves in the magnetotail by THEMIS observations
Authors: Zhang Shuai , Tian Anmin , Shi Quanqi , Li Hanlin , Degeling Alexander W. , Rae I. Jonathan , Forsyth Colin , Wang Mengmeng , Shen Xiaochen , Sun Weijie , Bai Shichen , Guo Ruilong , Wang Huizi , Fazakerley Andrew , Fu Suiyan , Pu Zuyin 
Published: October 2018

Abstract. Ultra-low-frequency (ULF) waves are ubiquitous in the magnetosphere. Previous
studies mostly focused on ULF waves in the dayside or near-Earth region (with
radial distance R<12 RE). In this study, using the
data of the Time History of Events and Macroscale Interactions during
Substorms (THEMIS) mission during the period from 2008 to 2015, the Pc5–6
ULF waves in the tail region with
XGSM∗<0, 8 RE<R<32 RE (mostly on the stretched magnetic field lines) are
studied statistically. A total of 1089 azimuthal oscillating events and
566 radial oscillating events were found. The statistical results show that
both the azimuthal and radial oscillating events in the magnetotail region
(12 RE<R<32 RE) are more
frequently observed in the post-midnight region. The frequency decreases with
increasing radial distance from Earth
for both azimuthal oscillating events (8 RE<R<16 RE) and radial oscillating events (8 RE<R<14 RE), which is consistent with the
field line resonances theory. About 52 % of events (including the
azimuthal and radial oscillating events) are standing waves in the region of
8–16 RE, while only 2 % are standing waves in the region of
16–32 RE. There is no obvious dawn–dusk asymmetry of ULF wave
frequency for events in 8 RE<R<32 RE, which contrasts with the obvious dawn–dusk asymmetry
found by previous studies in the inner magnetosphere (4 RE<R<9 RE). An examination for possible
statistical relationships between the ULF wave parameters and substorm
occurrences is carried out. We find that the wave frequency is higher after
the substorm onset than before it, and the frequency differences are more
obvious in the midnight region than in the flank region.
La responsabilidad y la ética de la Universidad en el entorno social
Authors: Ramírez Gálvez José Roberto 
Published: October 2018

En el presente artículo se hace referencia al rol que la responsabilidad y la ética de la universidad en el entorno social -considerando los cambios permanentes del mundo globalizado, de las incertidumbres por los cambios permanentes en el campo educativo- juega hoy con sometimiento a mayores exigencias en relación con la calidad de la educación, tanto a nivel local como nacional e internacional, producto de los cambios y de los retos en aras de brindar educación con calidad y con responsabilidad y ética empresarial. La universidad debe interactuar en diálogos con los distintos actores de estudiantes, docentes, empresas y representantes de la sociedad con el fin de obtener mayores criterios de entendimiento acerca de su desempeño y de su responsabilidad social con ética empresarial, identificando los aportes esenciales al desarrollo humano sostenible, pero considerando la responsabilidad y la ética empresarial como sinónimos de alta calidad en la enseñanza universitaria. La universidad debe centrarse en la suma de esfuerzos de todos los actores sociales, que conlleven a la colectividad con gestión de organización socialmente responsable, con formación académica, con producción del saber y con participación del desarrollo humano sostenible, procurando el involucramiento de los actores sociales, relación que incluye clientes, proveedores, socios, consumidores, medio ambiente, comunidades, el gobierno y la sociedad en general, y la consideración de factores sociales, económicos, éticos y responsabilidad social.
Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer
Authors: Guedes Liana B. , Morais Carlos L. , Fedor Helen , Hicks Jessica , Gurel Bora , Melamed Jonathan , Lee Peng , Gopalan Anuradha , Knudsen Beatrice S. , True Lawrence D. , Scher Howard I. , Fine Samson W. , Trock Bruce J. , De Marzo Angelo M. , Lotan Tamara L. 
Published: October 2018

Context.—
Phosphatase and tensin homolog (PTEN) is a promising prognostic and potentially predictive biomarker in prostate cancer.

Objective.—
To assess the effects of preanalytic variables on an analytically validated and fully automated PTEN immunohistochemistry assay.

Design.—
PTEN immunohistochemistry was performed on Ventana immunostaining systems. In benign prostate tissues, immunostaining intensity across variable conditions was assessed by digital image analysis. In prostate tumor tissues, immunostaining was scored visually.

Results.—
Delay of fixation for 4 hours or longer at room temperature or 48 hours or longer at 4°C and duration of formalin fixation did not significantly alter immunostaining intensity. Intensity of staining was highest in 10% formalin compared with other fixatives. Tumor tissues with PTEN loss processed using protocols from 11 academic institutions were all evaluable and scored identically. PTEN immunostaining of needle biopsies where tissue blocks had been stored for less than 10 years was more frequently scored as nonevaluable compared with blocks that had been stored for 10 years or longer. This effect was less evident for radical prostatectomy specimens, where low rates of nonevaluable staining were seen for 23 years or more of storage. Storage of unstained slides for 5 years at room temperature prior to immunostaining resulted in equivalent scoring compared with freshly cut slides. Machine-to-machine variability assessed across 3 Ventana platforms and 2 institutions was negligible in 12 tumors, and platform-to-platform variability was also minor comparing Ventana and Leica instruments across 77 tumors (κ = 0.926).

Conclusions.—
Automated PTEN immunostaining is robust to most preanalytic variables in the prostate and may be performed on prostate tumor tissues subjected to a wide range of preanalytic conditions. These data may help guide assay development if PTEN becomes a key predictive biomarker.
Relationship Between Hip Morphology and Hip‐Related Patient‐Reported Outcomes in Young and Middle‐Aged Individuals: A Population‐Based Study
Authors: Kopec Jacek A. , Qian Hong , Cibere Jolanda , Wong Hubert , Li Linda C. , Barber Morgan , Prlic Helen M. , Zhang Charlie , Ratzlaff Charles , Forster Bruce B. , Esdaile John M. ,   the IMPAKT‐HIP Study Team
Published: October 2018

ObjectiveRadiographic measurements of the alpha angle and the lateral center edge (LCE) angle in the hip joint are important for the diagnosis of femoroacetabular syndrome, a potential risk factor for hip osteoarthritis. Our objective was to determine whether these measurements are associated with hip‐related patient‐reported outcomes in young and middle‐aged individuals.MethodsA stratified random sample of white men and women ages 20–49 years, with and without hip pain, was selected using random digit dialing from the population of metro Vancouver, Canada. The alpha and LCE angles were measured bilaterally on radiographs using Dunn and anteroposterior views, respectively. Patient‐reported outcomes were measured by the Copenhagen Hip And Groin Outcome Score (HAGOS), which has scales for symptoms, pain, daily activities, sports, physical activity, and quality of life (QoL). We performed descriptive analyses and a regression analysis with restricted cubic splines, adjusted for age and sex and weighted for the sampling design.ResultsData were obtained for 500 subjects. The alpha angle distribution was strongly skewed, with a mean of 54°. The LCE angle distribution was symmetric, with a mean of 34°. In the restricted cubic splines analysis, the relationship between the alpha angle and HAGOS scores was nonlinear, with higher alpha angles generally associated with worse HAGOS scores for alpha >60°. The associations were statistically significant for symptoms, sports, and QoL. No association was found between the LCE angle and HAGOS scales.ConclusionIn a general population sample ages 20–49 years, we have found an association between the alpha angle and hip‐related patient‐reported outcomes.
Persistently Frequent Emergency Department Utilization Among Persons With Systemic Lupus Erythematosus
Authors: Lee Jiha , Lin Judith , Suter Lisa Gale , Fraenkel Liana 
Published: October 2018

ObjectiveIn order to identify opportunities to improve outpatient care, we evaluated patients with systemic lupus erythematosus (SLE) who persistently frequent the emergency department (ED).MethodsWe conducted a retrospective study of patients with SLE who frequented the ED for ≥3 visits in a calendar year, from 2013 to 2016. Persistent users were those who met criteria for persistent use for at least 2 of the 4 years, and limited users for 1 of the 4 years. Each ED encounter was categorized as SLE‐related, infection‐related, pain‐related, or other. We compared ED use between persistent and limited users, and analyzed factors associated with pain‐related encounters among persistent users through multivariate logistic regression.ResultsWe identified 77 participants who had 1,143 encounters as persistent users, and 52 participants who had 335 encounters as limited users. Persistent users accounted for 77% of ED use by patients with SLE who frequented the ED. Pain‐related ED visits were more common among persistent users (32%) than limited users (18%). Among persistent users, most pain‐related encounters were discharged from the ED (69%) or within 48 hours of admission (20%). Persistent users with pain‐related encounters accounting for >10% of ED use were more likely to be obese, have fewer comorbid conditions, and be on long‐term opioid therapy.ConclusionPain is a major cause of ED use. Patients with SLE who persistently utilize the ED for pain are likely to be noncritically ill, as evidenced by frequent discharges from the ED and short‐stay admissions. Patients with SLE who persistently frequent the ED for pain represent a viable target for interventions to improve outpatient quality of care.
Early Targeted Combination Treatment With Conventional Synthetic Disease‐Modifying Antirheumatic Drugs and Long‐Term Outcomes in Rheumatoid Arthritis: Ten‐Year Follow‐Up Results of a Randomized Clinical Trial
Authors: Rantalaiho Vappu , Sandström Tia , Koski Juhani , Hannonen Pekka , Möttönen Timo , Kaipiainen‐Seppänen Oili , Yli‐Kerttula Timo , Kauppi Markku J. , Uutela Toini , Malmi Timo , Julkunen Heikki , Laasonen Leena , Kautiainen Hannu , Leirisalo‐Repo Marjatta ,   for the NEO‐RACo Study Group
Published: October 2018

ObjectiveThe short‐term outcomes of remission‐targeted treatments of rheumatoid arthritis (RA) are well‐established, but the long‐term success of such strategies is speculative, as is the role of early add‐on biologics. We assessed the 10‐year outcomes of patients with early RA treated with initial remission‐targeted triple combination of conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs), 7.5‐mg prednisolone, and additional infliximab (IFX) or placebo infusions.MethodsNinety‐nine patients with early, DMARD‐naive RA were treated with a triple combination of csDMARDs and prednisolone and randomized to double‐blind receipt of infusions of either IFX (the Finnish Rheumatoid Arthritis Combination Therapy Trial [FIN‐RACo] + IFX) or placebo (FIN‐RACo + placebo) during the first 6 months. After 2 years, the treatment strategies became unrestricted, but the treatment goal was strict remission in the TNF‐Blocking Therapy in Combination With Disease‐Modifying Antirheumatic Drugs in Early Rheumatoid Arthritis (NEO‐RACo) study. At 10 years, the clinical and radiographic outcomes and the drug treatments used between 5 and 10 years were assessed.ResultsNinety patients (91%) were followed after 2 years, 43 in the FIN‐RACo + IFX and 47 in the FIN‐RACo + placebo group. At 10 years, the respective proportions of patients in strict NEO‐RACo remission and in Disease Activity Score using 28 joints remission in the FIN‐RACo + IFX and FIN‐RACo + placebo groups were 46% and 38% (P = 0.46) and 82% and 72% (P = 0.29), respectively. The mean total Sharp/van der Heijde score was 9.8 in the FIN‐RACo + IFX and 7.3 in the FIN‐RACo + placebo group (P = 0.34). During the 10‐year follow‐up, 26% of the FIN‐RACo + IFX group and 30% of the FIN‐RACo + placebo group had received biologics (P = 0.74).ConclusionIn early RA, excellent results can be maintained up until 10 years in most patients treated with initial combination csDMARDs and remission‐targeted strategy, regardless of initial IFX/placebo infusions.
Directly Visualizing Tactile Perception and Ultrasensitive Tactile Sensors by Utilizing Body‐Enhanced Induction of Ambient Electromagnetic Waves
Authors: Ren Zewei , Nie Jinhui , Xu Liang , Jiang Tao , Chen Baodong , Chen Xiangyu , Wang Zhong Lin 
Published: October 2018

AbstractTactile recognition is a critical technology for many applications. Here, it is found that the ambient electromagnetic signal, which is usually regarded as electromagnetic noise, can be a good triggering source to realize tactile detection. A circuit consisting of two light emitting diodes (LEDs) is designed as sensor unit and human contact can amplify the electrostatic signal induced by electromagnetic wave in this circuit, which enhances the brightness of the LEDs. Hence, visualizing tactile perception can be achieved based on this strategy. Accordingly, a stretchable and semi‐transparent sensor matrix is established for mapping detailed contact positions, on which the contact force can be smaller than 0.001 N. The detection and the visualization of sliding trajectory and pressure change are also demonstrated by using this sensory method, indicating its good applicability for different purposes. Electromagnetic wave universally exists in the working places and tactile sensors based on this strategy can be possibly applied to many fields such as factory automation, intelligent robotics, human–machine interaction, etc.