bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on dynamic optimal control strategy of distributed super capacitor energy storage system based on convolution neural network
Authors: Li Pengfei , Chen Hongyun , Wang Shangshang , Xu Zhipeng , Lei Zhenyu 
Published: October 2018

SummaryCompared with other modes of transport, urban rail transit has significant advantages such as large capacity, punctual safety, energy saving, and environmental protection. For pure electric buses, the problem of slow start, large battery energy loss, short battery life, and insufficient recovery of braking energy is caused by the use of single energy only. The power battery and super capacitor are combined to form a compound power supply to solve the problem. In order to improve the feature extraction ability of convolution neural networks, a deep convolution neural network model based on continuous convolution is designed. The model uses small scale convolution kernel to extract local features more carefully, and increases the nonlinear expression ability of the model by means of two continuous coiling layers. Dropout technology is used to reduce the interdependence between neurons, and the model is optimized by suppressing network overfitting. If the battery and the supercapacitor are combined to form a dual energy source system, it can not only meet the instantaneous high power demand of the electric vehicle but also prolong the life of the battery. Increasing the mileage of electric vehicles has become the development direction of pure electric vehicles. Due to its fast charging and discharging speed, long cycle life, and friendly environment, supercapacitor has unique advantages and development prospects in solving the problem of urban rail transit regeneration failure, performance analysis, modeling, and parameter identification of ultracapacitor. The performance of ultracapacitor is analyzed, and an improved dynamic equivalent circuit model of ultracapacitor is established. Therefore, this paper studies the control strategy of dual energy source storage system and the driving range of the dual energy source pure electric vehicle, which has a broad application prospect and practical significance.
Enhancing Phenotyping and Molecular Analysis of Plant Root System Using Ultrasound Aeroponic Technology
Authors: Pingault Lise , Zogli Prince , Brooks Jennifer , Libault Marc 
Published: October 2018

AbstractSeveral plant growth systems are available to enhance the observation of the root system (e.g., hydroponic and aeroponic plant growth systems, use of transparent soils, etc.). This article describes the use of the ultrasound aeroponic system (USAS) to treat and to enhance access to the root systems of various model plant and crop species (e.g., Arabidopsis thaliana, Medicago truncatula, soybean, etc.). This system is also compatible with short‐term (hr) and long‐term (days/weeks) biotic and abiotic treatments of plants. Upon treatment, the ease of access to the plant root system facilitates phenotyping (e.g., analysis of root architecture, establishment of root light spectrum using remote sensing technology), microscopic, molecular, and biochemical experiments. In addition, to facilitate functional genomic studies, we combined the use of the USAS with the hairy root transformation system to grow and observe transgenic roots on composite legume plants. © 2018 by John Wiley & Sons, Inc.
A comparative study of two separation methods to isolate monocytes
Authors: Weiss Ronald , Gerdes Wilhelm , Leonhardt Franziska , Berthold Rommy , Sack Ulrich , Grahnert Anja 
Published: October 2018

AbstractSeparation of specific blood cells is necessary for a deeper insight into their role in health and disease. To obtain such cells, efficient and robust isolation methods are needed. We compare here the Fab‐based Traceless Affinity Cell Selection (TACS®) technology and the Magnetic Activated Cell Sorting (MACS®) technology to isolate human monocytes from whole blood and buffy coats as well as the differentiation of the isolated monocytes to dendritic cells (DCs). TACS® is a positive selection technology using immune affinity chromatography based on CD‐specific low affinity Fab‐fragments for the reversible capture and release of target cells. The positive selection by MACS® is based on magnetic beads coated with specific high affinity monoclonal antibodies to catch the target cells. The target cells separated by TACS® are “label‐free” while cells positively isolated by MACS® will carry the cell specific label. Our data show that the separation methods described here are well suited to obtain functional monocytes of high quality and purity. A differentiation of the cells into DCs leads to comparable results with the exception that CD1a expression levels on immature and mature DCs are elevated when monocytes are isolated using the TACS® technology. Taken together, our results suggest that the TACS® method may be of advantage when preparing monocytes and monocyte‐derived DCs for functional analyses, while the MACS® method seems to be capable of higher monocyte recoveries. © 2018 International Society for Advancement of Cytometry
Protective role of fucoxanthin in diethylnitrosamine‐induced hepatocarcinogenesis in experimental adult rats
Authors: Jin Xin , Zhao TingTing , Shi Dan , Ye Ming Bao , Yi Qiying 
Published: October 2018

AbstractHepatocellular carcinoma (HCC) accounts for majority of cancer related deaths. Two major risk factors in induction of HCC are chemical and virus, however, the possible mechanisms of their differences remain indefinable. The current study focused on protective role of Fucoxanthin (Fx) in liver affected by diethylnitrosamine (DEN)‐induced HCC. In this study, levels of liver enzymes, oxidative stressors, antioxidant status, and lipoproteins were compared both in tissue and blood. Tissues were also analyzed extensively by histological studies using H and E staining and transmission electron microscopy (TEM). Rats were clustered into four groups of six experimental animals. Group I: Control rats were administered isotonic saline intraperitoneal Group II: Animals received 0.01% DEN through drinking water to induce hepatocellular carcinoma. Group III: Animals received 0.01% DEN simultaneously oral supplementation of Fx (50 mg/kg b.w). Group IV: Rats were given Fx alone (50 mg/kg b.w) orally and the treatment is for 15 weeks. Results showed the decrease in body weight, serum albumin, antioxidant enzymes, and increased all the liver enzymes, serum bilirubin, and stress markers in DEN induced rats, where as the simultaneous supplementation of Fx reverted them to normal levels. Administration of only Fx did not show any change. Therefore, Fx may serve as a chemotherapeutic agent against liver cancer.
Galectin‐3 and risk of cardiovascular events and all‐cause mortality in type 2 diabetes
Authors: Tan Kathryn C.B. , Cheung Ching‐Lung , Lee Alan C.H. , Lam Joanne K.Y. , Wong Ying , Shiu Sammy W.M. 
Published: October 2018

AbstractAimsRecent clinical studies have shown that galectin‐3 is a prognostic indicator in patients with coronary heart disease and in patients with heart failure. Experimental data suggest that galectin‐3 may play a role in atherogenesis. We have evaluated whether serum galectin‐3 level is associated with cardiovascular outcome in type 2 diabetes.Materials and methodsGalectin‐3 was measured in baseline samples in 1495 persons with type 2 diabetes. The primary cardiovascular outcome, incident cardiovascular events, was defined as first non‐fatal myocardial infarction, non‐fatal stroke, coronary revascularization, or death from cardiovascular cause. The secondary outcome was all‐cause mortality.ResultsAt baseline, 12% of the subjects had prevalent cardiovascular disease. Serum galectin‐3 was increased in the group with incident cardiovascular events compared with those who remained free of events during follow up (9.03 ± 2.98 ng/mL vs 8.15 ± 2.76, P < 0.01). Serum galectin‐3 was also significantly increased in those subjects with a fatal outcome. The hazard ratios (HR) for cardiovascular events and all‐cause mortality for individuals in the top quartile were 2.50 (95% CI 1.87, 3.36, P < 0.001) and 3.92 (95%CI 2.55, 6.01, P < 0.001), respectively. In a multivariate Cox regression analysis including traditional risk factors, log (eGFR), baseline albuminuria, and cardiovascular disease status, the HR per standard deviation change in galectin‐3 was 1.13 (95% CI 1.02, 1.26, P = 0.02) for cardiovascular events and 1.17 (95% CI 1.01, 1.35, P = 0.04) for all‐cause mortality.ConclusionsSerum galectin‐3 is associated with adverse cardiovascular outcomes in persons with type 2 diabetes independent of traditional risk factors.
Effects of model choice, network structure, and interaction strengths on knockout extinction models of ecological robustness
Authors: Bane Miranda S. , Pocock Michael J. O. , James Richard 
Published: October 2018

AbstractAnalysis of ecological networks is a valuable approach to understanding the vulnerability of systems to disturbance. The tolerance of ecological networks to coextinctions, resulting from sequences of primary extinctions (here termed “knockout extinction models”, in contrast with other dynamic approaches), is a widely used tool for modeling network “robustness”. Currently, there is an emphasis to increase biological realism in these models, but less attention has been given to the effect of model choices and network structure on robustness measures. Here, we present a suite of knockout extinction models for bipartite ecological networks (specifically plant–pollinator networks) that can all be analyzed on the same terms, enabling us to test the effects of extinction rules, interaction weights, and network structure on robustness. We include two simple ecologically plausible models of propagating extinctions, one new and one adapted from existing models. All models can be used with weighted or binary interaction data. We found that the choice of extinction rules impacts robustness; our two propagating models produce opposing effects in all tests on observed plant–pollinator networks. Adding weights to the interactions tends to amplify the opposing effects and increase the variation in robustness. Variation in robustness is a key feature of these extinction models and is driven by the structural heterogeneity of nodes (specifically, the skewness of the plant degree distribution) in the network. Our analysis therefore reveals the mechanisms and fundamental network properties that drive observed trends in robustness.
Invasive species denialism: Sorting out facts, beliefs, and definitions
Authors: Boltovskoy Demetrio , Sylvester Francisco , Paolucci Esteban M. 
Published: October 2018

AbstractIn the last decades, thousands of investigations confirmed the detrimental effects of species translocated by man outside of their native ranges (nonindigenous species, or NIS). However, results concluding that many NIS have null, neutral, or positive impacts on the biota and on human interests are as common in the scientific literature as those that point at baneful impacts. Recently, several scholars confronted the stand that origin per se is not a reliable indicator of negative effects, suggesting that such conclusions are the expression of scientific denialism, often led by spurious purposes, and that their numbers are increasing. When assessed in the context of the growing interest in introduced species, the proportion of academic publications claiming that NIS pose no threats to the environment and to social and economic interests is extremely low, and has not increased since 1990. The widely prevailing notion that many NIS are effectively or potentially harmful does not conflict with the fact that most have mixed (negative, neutral, and positive) impacts. When based on solid grounds, reports of positive or neutral impacts should not be labeled as manipulative or misleading unless proven otherwise, even if they may hamper interest in‐ and funding of research and control bioinvasion programs.
Embryonal life histories: Desiccation plasticity and diapause in the Argentinean pearlfish Austrolebias bellottii
Authors: Van Dooren Tom J. M. , Varela‐Lasheras Irma 
Published: October 2018

AbstractEmbryos of annual killifish diapause in soil egg banks while ponds are dry. Their rates of development and survival in different developmental stages determine the numbers and stages of embryos at rewetting. In the Argentinean pearlfish Austrolebias bellottii, we investigated plasticity for desiccation in such embryonal life history components across phases of mild desiccation and rewetting and also effects of life history on hatching. In comparison with nonannuals, our data suggest that incidences of diapause have become relatively independent of the occurrence of desiccation, as if they have become genetically assimilated. We found limited survival effects of desiccation, limited developmental delays, and an acceleration of development into the prehatching stage. This response can be adaptive when desiccation informs that an opportunity to hatch approaches. Embryos arrest development in the prehatching stage (diapause DIII) or in the dispersed‐cell phase (diapause DI). Parental pair variation in rates of development and survival in the earliest developmental stages affects the fraction of embryos that are in DI at rewetting and the number surviving. Given such effects on life history fitness components, rates during embryonal development seem "visible" to selection and the developmental system can thus adapt when pair variation contains a heritable component. In agreement with expectations for the presence of diversified bet‐hedging, some embryos hatched and others not in over half of the clutches with several developed embryos at the moment of rewetting. Hatching probabilities increased for eggs produced later in the experiment, and they increased when embryos were rewetted a second time after two months. This response is opposite of what is expected when age‐dependent hatching would be adapted to exploit opportunities for completing another generation before the dry season.
Power increases the self‐serving bias in the attribution of collective successes and failures
Authors: Lammers Joris , Burgmer Pascal 
Published: October 2018

AbstractThree studies test the effect of power on the self‐serving bias in attributing collective outcomes. The first two studies measure (Experiment 1) and manipulate (Experiment 2) power and then measure the internal (vs. external) attribution of past successes and failures. Consistently, those who feel powerful show a stronger self‐serving tendency to selectively attribute successes internally and failures externally than those who feel powerless. Experiment 3 compares the effects of power (control over others) and personal control (over oneself). We find that power increases the self‐serving bias, but a lack of control can limit this effect by reducing the external attribution of failures. Presumably, people who lack control are disinclined to attribute outcomes—including failures—externally because doing so would further aggravate their lack of control. Together, these results suggest that power increases a bias in the attribution of success and failure and thus presents a fundamental challenge to good leadership.
Performance evaluation of amplify‐and‐forward relaying cooperative vehicular networks under physical layer security
Authors: Pandey Anshul , Yadav Suneel 
Published: October 2018

AbstractIn this paper, we address the physical layer security of a cooperative vehicular network in the presence of a passive eavesdropper vehicle, where the communication from a fixed source node to a fixed destination node is assisted by an amplify‐and‐forward relay vehicle and by direct link, in two transmission phases. Based on the security of the first transmission phase, we consider two scenarios for the cooperative vehicular networks. In Scenario I, the first phase is secure (ie, the direct link between source and eavesdropper is not available) and the eavesdropping occurs only in the second phase. In Scenario II, the first phase is not secure (ie, the direct link between source and eavesdropper is present) and the eavesdropping occurs during both the first and second phases. We assume that source‐to‐destination, source‐to‐relay vehicle, relay vehicle‐to‐destination, and source‐to‐eavesdropper vehicle channels are modeled as Rayleigh fading, whereas the channel between relay and eavesdropper vehicles is modeled by double‐Rayleigh fading. Under such channel modeling, we deduce the new tight closed‐form expressions for the secrecy outage probability (SOP) under both Scenario I and Scenario II. We also investigate the effective secrecy diversity order in the high main‐to‐eavesdropper ratio (MER) regime. The numerical and simulation results corroborate our theoretical analysis and findings and show the occurrence condition for SOP floor phenomenon and influences of channel conditions and relay and eavesdropper locations on the SOP performance. Our results also reveal that the presence of source‐to‐eavesdropper link has significant impact on the SOP performance and relay location.
Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation
Authors: Singh Komudi , Han Kim , Tilve Sharada , Wu Kaiyuan , Geller Herbert M. , Sack Michael N 
Published: October 2018

AbstractLoss of substantia nigra dopaminergic neurons results in Parkinson disease (PD). Degenerative PD usually presents in the seventh decade whereas genetic disorders, including mutations in PARK2, predispose to early onset PD. PARK2 encodes the parkin E3 ubiquitin ligase which confers pleotropic effects on mitochondrial and cellular fidelity and as a mediator of endoplasmic reticulum (ER) stress signaling. Although the majority of studies investigating ameliorative effects of parkin focus on dopaminergic neurons we found that astrocytes are enriched with parkin. Furthermore, astrocytes deficient in parkin display stress‐induced elevation of nucleotide‐oligomerization domain receptor 2 (NOD2), a cytosolic receptor integrating ER stress and inflammation. Given the neurotropic and immunomodulatory role of astrocytes we reasoned that parkin may regulate astrocyte ER stress and inflammation to control neuronal homeostasis. We show that, in response to ER stress, parkin knockdown astrocytes exhibit exaggerated ER stress, JNK activation and cytokine release, and reduced neurotropic factor expression. In coculture studied we demonstrate that dopaminergic SHSY5Y cells and primary neurons with the presence of parkin depleted astrocytes are more susceptible to ER stress and inflammation‐induced apoptosis than wildtype astrocytes. Parkin interacted with, ubiquitylated and diminished NOD2 levels. Additionally, the genetic induction of parkin ameliorated inflammation in NOD2 expressing cells and knockdown of NOD2 in astrocytes suppressed inflammatory defects in parkin deficient astrocytes and concurrently blunted neuronal apoptosis. Collectively these data identify a role for parkin in modulating NOD2 as a regulatory node in astrocytic control of neuronal homeostasis.
Characterizing hippocampal dynamics with MEG: A systematic review and evidence‐based guidelines
Authors: Ruzich Emily , Crespo‐García Maité , Dalal Sarang S. , Schneiderman Justin F. 
Published: October 2018

AbstractThe hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro‐temporal aspects of function, for example, neural oscillations and network timing, especially in shallow cortical structures. However, the decrease in MEG signal‐to‐noise ratio as a function of source depth implies that the utility of MEG for investigations of deeper brain structures, including the hippocampus, is less clear. To determine whether MEG can be used to detect and localize activity from the hippocampus, we executed a systematic review of the existing literature and found successful detection of oscillatory neural activity originating in the hippocampus with MEG. Prerequisites are the use of established experimental paradigms, adequate coregistration, forward modeling, analysis methods, optimization of signal‐to‐noise ratios, and protocol trial designs that maximize contrast for hippocampal activity while minimizing those from other brain regions. While localizing activity to specific sub‐structures within the hippocampus has not been achieved, we provide recommendations for improving the reliability of such endeavors.
An examination of health promotion and social inclusion activities: A cross‐sectional survey of Australian community Men's Sheds
Authors: Wilson Nathan J. , Cordier Reinie , Parsons Richard , Vaz Sharmila , Ciccarelli Marina 
Published: October 2018

AbstractIssue addressedThe activities and well‐being outcomes from participating at Men's Sheds are the focus of a growing body of research. Although many Men's Sheds have a clear health or social philosophy, this does not always translate into health and social activities.MethodThis cross‐sectional survey explored the health promotion and social inclusion activities of Men's Sheds and features of Sheds that predict greater levels of these activities. All Australian Men's Sheds were invited to participate. Based on survey responses, Sheds were classified as “active” or “not active” in health promotion and social inclusion, which formed the main survey outcomes. Profiles of the responding Sheds were summarised and compared against the main survey outcomes. Multivariate logistic regression analyses explored the profile variables associated with “active” Sheds.ResultsResponses from 300 Sheds indicated 37% and 70% of Sheds were “active” in health promotion and social inclusivity respectively. Number of members, members with mental illness or of Indigenous descent, providing meals and targeting war veterans were associated with health promotion. Having five or more members with a disability, members with English as a second language, targeting of war veterans were associated with social inclusiveness.ConclusionsMen's Sheds may serve as a unique community resource to reduce barriers of access to preventative health care, education and social connectedness, especially for marginalised members and those living in rural communities.So what?A proportion of Men's Sheds reflects the health and well‐being exemplars mentioned in the National Male Health Policy that can help to counter the social determinants of poor health, particularly for marginalised males.