bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I/II Study of Palliative Triple Metronomic Chemotherapy in Platinum-Refractory/Early-Failure Oral Cancer
Authors: Patil Vijay M. , Noronha Vanita , Joshi Amit , Dhumal Sachin , Mahimkar Manoj , Bhattacharjee Atanu , Gota Vikram , Pandey Manish , Menon Nandini , Mahajan Abhishek , Sable Nilesh , Kumar Suman , Nawale Kavita , Mukadam Sadaf , Solanki Bhavin , Das Sudeep , Simha Vijai , Abraham George , Chandrasekharan Arun , Talreja Vikas , DSouza Hollis , Srinivas Sujay , Kashyap Lakhan , Banavali Shripad , Prabhash Kumar 
Published: September 2019

PURPOSE Platinum-resistant oral cancer has a dismal outcome with limited treatment options. We conducted a phase I/II study to identify the optimal biologic dose (OBD) of methotrexate when given along with erlotinib and celecoxib and to assess the efficacy of this three-drug regimen in advanced oral cancer. METHODS Patients with platinum-resistant or early-failure squamous cell carcinoma of the oral cavity were eligible for this study. They were orally administered erlotinib 150 mg once per day, celecoxib 200 mg twice per day, and methotrexate per week. The primary end point of phase I was to determine the OBD of methotrexate, and that of phase II was to determine the 3-month progression-free survival. The OBD of methotrexate was determined on the basis of the clinical benefit rate at 2 months and circulating endothelial cell level at day 8, using a de-escalation model. Pharmacokinetic evaluation was performed during phase I. Phase II consisted of an expansion cohort of 76 patients. RESULTS Fifteen patients were recruited in phase I, and 9 mg/m2 methotrexate was identified as the OBD. A total of 91 patients were recruited, and the median follow-up was 6.8 months (range, 0 to 16.8 months). The 3-month progression-free survival rate was 71.1% (95% CI, 60.5% to 79.3%), the 6-month overall survival rate was 61.2% (95% CI, 49.2% to 67.8%), and the response rate was 42.9% (95% CI, 33.2% to 53.1%; n = 39). The mean Functional Assessment of Cancer Therapy-Head and Neck Trial Outcome Index score at day 8 was improved by 6.1 units (standard deviation, 13.6 units) and was maintained around this magnitude ( P = .001). CONCLUSION Triple oral metronomic chemotherapy with erlotinib, methotrexate, and celecoxib is efficacious in platinum-refractory oral cavity cancers and represents a new therapeutic option in patients with poor prognosis.
Association Between Postoperative Body Temperature and All-Cause Mortality After Off-Pump Coronary Artery Bypass Graft Surgery: A Retrospective Observational Study
Authors: Nam Karam , Jo Woo Young , Kwon Seok Min , Kang Pyoyoon , Cho Youn Joung , Jeon Yunseok , Kim Tae Kyong 
Published: September 2019

BACKGROUND:
Inadvertent perioperative hypothermia is common in patients undergoing off-pump coronary artery bypass grafting (OPCAB). We investigated the association between early postoperative body temperature and all-cause mortality in patients undergoing OPCAB.

METHODS:
We reviewed the electronic medical records of 1714 patients who underwent OPCAB (median duration of follow-up, 47 months). Patients were divided into 4 groups based on body temperature at the time of intensive care unit admission after surgery (moderate-to-severe hypothermia, <35.5°C; mild hypothermia, 35.5°C–36.5°C; normothermia, 36.5°C–37.5°C; and hyperthermia, ≥37.5°C). Cox proportional hazards models were used to assess the association between body temperature and all-cause mortality. The association between early postoperative changes in body temperature and all-cause mortality was also assessed by dividing the patients into 4 categories according to the body temperature measured at postoperative intensive care unit admission and the average body temperature during the first 3 postoperative days.

RESULTS:
Compared to the normothermia group, the adjusted hazard ratios of all-cause mortality were 2.030 (95% confidence interval, 1.407–2.930) in the moderate-to-severe hypothermia group and 1.445 (95% confidence interval, 1.113–1.874) in the mild hypothermia group. Patients who were hypothermic at postoperative intensive care unit admission but attained normothermia thereafter were at a lower risk of all-cause mortality compared to patients who did not regain normothermia (adjusted hazard ratio, 0.631; 95% confidence interval, 0.453–0.878), while they were still at a higher risk of all-cause mortality than those who were consistently normothermic (adjusted hazard ratio, 1.435; 95% confidence interval, 1.090–1.890).

CONCLUSIONS:
Even mild early postoperative hypothermia was associated with all-cause mortality after OPCAB. Patients who regained normothermia postoperatively were at lower risk of all-cause mortality compared to those who did not.
McGrath MAC Videolaryngoscope Versus Optiscope Video Stylet for Tracheal Intubation in Patients With Manual Inline Cervical Stabilization: A Randomized Trial
Authors: Yoon Hyun-Kyu , Lee Hyung-Chul , Park Jung-Bin , Oh Hyongmin , Park Hee-Pyoung 
Published: September 2019

BACKGROUND:
Manual inline stabilization of the head and neck is a recommended maneuver for tracheal intubation in patients with a suspected cervical injury. However, because applying this maneuver inevitably restricts neck flexion and head extension, indirect intubating devices such as a videolaryngoscope or a video stylet could be required for successful tracheal intubation. In this study, we compared the clinical performance of the McGrath MAC videolaryngoscope versus the Optiscope video stylet in patients with manual inline cervical stabilization during tracheal intubation.

METHODS:
In 367 consecutive patients undergoing elective cervical spine surgery, tracheal intubation was randomly performed with manual inline stabilization using either the McGrath MAC videolaryngoscope (group M, n = 183) or the Optiscope video stylet (group O, n = 184) by 2 experienced anesthesiologists in a single institution. The primary outcome was the first-attempt success rate of tracheal intubation. Secondary outcomes were intubation time and the incidence of postoperative airway complications, such as sore throat, hoarseness, blood in the oral cavity, and blood staining on the endotracheal tube.

RESULTS:
The first-attempt success rate of tracheal intubation was significantly higher in group M compared with group O (92.3% vs 81.0%; risk difference [95% confidence interval], 0.11 [0.05–0.18]; P = .002). The intubation time was significantly shorter in group M than in group O (35.7 ± 27.8 vs 49.2 ± 43.8; mean difference [95% confidence interval], 13.5 [5.9–21.1]; P = .001). The incidence of postoperative airway complications was not significantly different between the 2 groups.

CONCLUSIONS:
The McGrath MAC videolaryngoscope showed a higher first-attempt success rate for tracheal intubation and a shorter intubation time than the Optiscope video stylet in cervical spine patients with manual inline stabilization during tracheal intubation. These results suggest that the McGrath MAC videolaryngoscope may be a better option for tracheal intubation in such patients.
FKBP52 regulates TRPC3-dependent Ca2+ signals and the hypertrophic growth of cardiomyocyte cultures
Authors: Bandleon Sandra , Strunz Patrick P. , Pickel Simone , Tiapko Oleksandra , Cellini Antonella , Miranda-Laferte Erick , Eder-Negrin Petra 
Published: September 2019

ABSTRACT
The transient receptor potential (TRP; C-classical, TRPC) channel TRPC3 allows a cation (Na+/Ca2+) influx that is favored by the stimulation of Gq protein-coupled receptors (GPCRs). An enhanced TRPC3 activity is related to adverse effects, including pathological hypertrophy in chronic cardiac disease states. In the present study, we identified FK506-binding protein 52 (FKBP52, also known as FKBP4) as a novel interaction partner of TRPC3 in the heart. FKBP52 was recovered from a cardiac cDNA library by a C-terminal TRPC3 fragment (amino acids 742–848) in a yeast two-hybrid screen. Downregulation of FKBP52 promoted a TRPC3-dependent hypertrophic response in neonatal rat cardiomyocytes (NRCs). A similar effect was achieved by overexpressing peptidyl-prolyl isomerase (PPIase)-deficient FKBP52 mutants. Mechanistically, expression of the FKBP52 truncation mutants elevated TRPC3-mediated currents and Ca2+ fluxes, and the activation of calcineurin and the nuclear factor of activated T-cells in NRCs. Our data demonstrate that FKBP52 associates with TRPC3 via an as-yet-undescribed binding site in the C-terminus of TRPC3 and modulates TRPC3-dependent Ca2+ signals in a PPIase-dependent manner. This functional interaction might be crucial for limiting TRPC3-dependent signaling during chronic hypertrophic stimulation.
Quem tem medo da Teoria? Análise como vivência, prática e experimentação nas Relações Internacionais | Who is affraid of Theory? Analysis as experience, practice and experimentation in International Relations
Authors: Spode Raphael , Fernandes Olivieri Bruna 
Published: September 2019

O anseio de implementação de atividades práticas é uma questão histórica do campo de estudos das Relações Internacionais. Se, por um lado, muito pouco se tem descoberto sobre o aspecto prático e técnico da área – o que tem feito das Relações Internacionais uma área muito mais reflexiva e filosófica, do que propriamente um campo profissionalizante –, por outro lado algumas iniciativas podem ser encontradas, no Brasil e no mundo, capazes de oferecer aos alunos uma vivência profissional na graduação. Até aqui, a consagrada simulação das organizações internacionais tem sido o cerne da prática nas Relações Internacionais, concorrendo ao aprimoramento das habilidades de oratória e negociação dos alunos. Junto a ela, porém, há uma dinâmica relativamente desconhecida, de importância fundamental, denominada “Laboratório de Análise das Relações Internacionais (LARI)”. Esse artigo é um relato de experiências do “LARI” enquanto metodologia ativa de aprendizagem e uma breve reflexão sobre suas possibilidades e limitações.Palavras-chave: Virada Prática; Metodologias Ativas; Teoria das Relações Internacionais. ABSTRACTThe longing for the implementation of practical activities is a historical question of the field of studies of IR. If, on the one hand, very little has been discovered about the practical and technical aspect of the area – which has made IR a much more reflexive and philosophical area – on the other hand some initiatives may be found in Brazil and in the world capable of offering students a professional experience in undergraduate studies. So far, the established simulation of international organizations has been at the heart of International Relations practice, contributing to the improvement of students' speaking and negotiation skills. Next to it, however, there is a relatively unknown dynamics of fundamental importance denominated "Laboratory of Analysis of International Relations (LARI)". This article is an account of experiences of "LARI" as an active learning methodology and a reflection on its possibilities and limitations.Keywords: Practice Turn; Active Learning; International Relations Theory. Recebido em 26 out.2018 | Aceito em 20 ago.2019
A Revista Dabiq e a construção do inimigo: uma análise das classificações utilizadas pelo DAESH para nomear os seus opositores | The Dabiq Magazine and the construction of the enemy: an analysis of the classifications used by the DAESH to nominate its opponents
Authors: Costa Leandro Loureiro 
Published: September 2019

A organização terrorista Estado Islâmico tem sido obstáculo para a segurança política em diversas regiões do mundo. Esta incerteza ocorre tanto pela promoção de atentados, mas também pela capacidade do grupo em recrutar indivíduos para que lutem pelos seus interesses. Para tal objetivo, desenvolveu-se uma máquina de propaganda com poder de construir representações demonizadas do inimigo e criar fortes identificações para os que partilham das ideias da organização. Esta pesquisa se baseou na Revista Dabiq para analisar como o mundo social do grupo foi construído. A partir dos seus textos e imagens foi possível compreender quais são os elementos que o compõem, dando subsídios para estudos mais específicos sobre a problemática do extremismo islâmico. Estes padrões lexicais caracterizam os chamados “inimigos” do Estado Islâmico, além da própria identificação do “eu” do grupo estar diretamente ligada a definição do “outro”, são parte de uma visão de mundo que busca responder às crises da modernidade, propondo uma substituição radical baseada na violência.Palavras-chave: Estado Islâmico; Revista Dabiq; Extremismo Islâmico. ABSTRACTThe terrorist organization Islamic State has been an obstacle to political security in various regions of the world. This uncertainty occurs both for the promotion of attacks, but also for being able to recruit young people around the world to fight in accordance with the interests of the group. To this end, a propaganda machine was developed with the power to construct demonized representations of the enemy and to create strong identifications for those who share the ideas of the organization. This research was based on Dabiq Magazine to analyze how the social world of the group was constructed. From its texts and images it was possible to understand which are the elements that make up the same, giving subsidies for more specific studies on the problematic of Islamic extremism. These lexical patterns characterize the so-called "enemies" of the Islamic State, and the very identification of the group's "I" is directly linked to this definition of the "other." These are part of a worldview that seeks to respond to the crises of modernity by proposing a radical substitution based on violence.Keywords: Islamic State; Dabiq Magazine; Islamic Extremism. Recebido em 14 mai.2019 | Aceito em 19 ago.2019.
Competence in using the arthroscopy stack system: a national survey of orthopaedic trainees in the UK
Authors: Manoharan G , Sharma N , Gallacher P 
Published: September 2019

Introduction Surgeons are required to have a sound knowledge regarding all operating theatre equipment they wish to use. This is important to ensure patient safety and theatre efficiency. Arthroscopy forms a significant part of all orthopaedic subspecialty practice. Proficiency in performing arthroscopic procedures is assessed during registrar training. The aim of this survey was to determine the competence of orthopaedic trainee registrars in setting up the arthroscopy stack system and managing intraoperative problems. Materials and methods Electronic survey forms were sent to all orthopaedic training programme directors in the UK to be forwarded to trainees in their deanery. The electronic survey contained 13 questions aimed at determining trainee experience and competence level with working with the arthroscopy stack system. Results A total of 138 responses were received from 14 deaneries in the UK. Almost all registrars had experienced intraoperative delays because of equipment malfunction that required addressing by more competent staff. However, 82% of respondents had not received any formal training for operating the arthroscopy stack system. Some 82% of registrars of ST7 grade or above, who had performed over 50 arthroscopic procedures and achieved a level 4 PBA competence, were unable to set up the stack system and successfully address these delays. Conclusions Inadequate training is delivered to orthopaedic registrars from both the training programme and arthroscopy-themed courses with regards to set-up and operation of the arthroscopy tower system. This training should be part of the curriculum to ensure patient safety and efficient theatre practice.
Iodine status of the population in Russia and the world: what do we have for 2019?
Authors: Alferova Vlada I. , Mustafina Svetlana V. , Rymar Oksana D. 
Published: September 2019

The article presents the most relevant data of the world literature on the problem of iodine status. The problem of iodine deficiency still remains unresolved on the territory of the former Soviet Union (the median urinary iodine was 29.1 μg/l in Abkhazia, and almost 30% of the examined had the level of ioduria below standard values in Kazakhstan), although some countries have been successful in dealing with iodine deficiency (the median urinary iodine is 191 μg/l in Belarus, 169 μg/l in Ukraine). On the rest of the Eurasian continent, the picture is also different: among the total mass of countries with normal median urinary iodine, there are territories with both iodine deficiency (the median of ioduria ranges from 80 to 138 μg/l in the UK, the median of ioduria is 63 μg/l in France) and its excessive consumption (the median of ioduria is 330.0 μg/l in China). On the territory of America, in 2016, the elimination of iodine deficiency was announced (the median of ioduria ranged from 123 μg/l (Argentina) to 415 μg/l (Colombia)), and Haiti was the only country with a fixed iodine deficiency – 84 μg/l. Research data from different years in the following regions of the Russian Federation are presented: Moscow (the median of ioduria 67.0 μg/l), St. Petersburg (66.0–86.0 μg/l), Tyumen region (106.9 μg/l), Novosibirsk region (93.0 μg/l), Republic of Bashkortostan (70.3 μg/l), Republic of Dagestan (65.8 μg/l), Kemerovo region (90.0 μg/l), Saratov region (59.0–106.0 μg/l), Tomsk region (94 μg/l), Far Eastern region (58.0–74 μg/l), Chelyabinsk region (92.0–164.5 μg/l), Chuvash Republic (72.0 μg/l), Perm region (100.0 μg/l). Almost throughout the Russian Federation, iodine deficiency of mild severity was noted.
A comparative study of tapped and untapped pilot holes for bicortical orthopedic screws – 3D finite element analysis with an experimental test
Authors: Ketata Hajer , Affes Fatma , Kharrat Mohamed , Dammak Maher 
Published: September 2019

Abstract
The aim of this study was to compare the screw-to-bone fixation strength of two insertion techniques: self-tapping screw (STS) and non-self-tapping screw (NSTS). Finite element analysis (FEA) was used for the comparison by featuring three tests (insertion, pull-out and shear) in a human tibia bone model. A non-linear material behavior with ductile damage properties was chosen for the modeling. To validate the numerical models, experimental insertion and pull-out tests were carried out using a synthetic bone. The experimental and numerical results of pull-out tests correlated well. Thread forming was successfully simulated during the insertion process of STS and NSTS. It is demonstrated that the STS generates higher insertion torque, induces a higher amount of stress after the insertion process and relatively more strength under the pull-out and shear tests than the NSTS. However, the NSTS induces more stiffness under the two tests (pull-out and shear) and less damage to the screw-bone interface compared to the STS. It is concluded that the use of STS ensures tighter bony contact and enables higher pull-out strength; however, the use of NSTS improves the stiffness of the fixation and induces less damage to the cortical bone-screw fixation and thus minimum risk is obtained in terms of bone necrosis.
Two-center comparison of 10 fully-automated commercial procalcitonin (PCT) immunoassays
Authors: Lippi Giuseppe , Salvagno Gian Luca , Gelati Matteo , Pucci Mairi , Lo Cascio Claudia , Demonte Davide , Faggian Diego , Plebani Mario 
Published: September 2019

Abstract

Background
This two-center study was designed to verify comparability of procalcitonin (PCT) values among 10 different commercial immunoassays.

Methods
A total number of 176 routine lithium-heparin plasma samples were divided in identical aliquots and simultaneously analyzed with 10 different PCT immunoassays, including Kryptor BRAHMS PCT sensitive, Abbott Architect BRAHMS PCT, Beckman Coulter Access PCT (on Access and DXI), BioMérieux Vidas BRAHMS PCT, Diasorin Liaison BRAHMS PCT, Fujirebio Lumipulse G BRAHMS PCT, Roche BRAHMS PCT (on Cobas E801), Diazyme PCT (on Roche Cobas C702) and SNIBE Maglumi PCT.

Results
Highly significant correlation was always found across multiple comparisons, with correlation coefficients comprised between 0.918 and 0.997 (all p < 0.001). Bland and Altman plots analysis revealed highly variable bias among immunoassays, ranging between ±0.2% and ±38.6%. Diazyme PCT on Roche Cobas C702 and SNIBE Maglumi PCT displayed the larger overestimation, whilst PCT values were underestimated by Cobas BRAHAMS PCT. The agreement was always >80% (all p < 0.001), but varied largely across multiple comparisons, ranging between 90%–99% at 0.1 μg/L, 81%–99% at 0.25 μg/L, 83%–100% at 0.5 μg/L, 94%–100% at 2.0 μg/L and 90%–99% at 10 μg/L, respectively. The larger disagreement was observed comparing Diazyme PCT and Maglumi PCT with the other methods.

Conclusions
Although we found acceptable correlation among 10 commercial PCT immunoassays, the limited agreement at clinical decision thresholds remains a major issue, especially at lower end of PCT concentration, thus potentially contributing to jeopardize the clinical value of this biomarker.
Development of an Assistance System for the Intuitive Assessment of Laboratory Findings in Oncology
Authors: Oeser Alexander , Gaebel Jan , Kuhnt Thomas 
Published: September 2019

Abstract
Due to the broad spectrum of individual functionalities, current hospital information systems in most cases do not offer quick information access or proper assistance in information assessment. This results in extensive use of raw value representations and the need to process and evaluate those cognitively through the physician. This can result in an error-prone and ineffective process, especially in complex and chronic treatment scenarios. With an example scenario of laboratory value assessment in head and neck oncology, we have evaluated the requirements for extensive support of case interpretation through the conduction of a Delphi study including five medical experts with different levels of expertise. Based on the results, we propose a solution with integrated HL7 FHIR compliant clinical decision-support functionality through a set of integrated rules from relevant clinical practice guidelines. Furthermore, we introduce the implementation of a dedicated application that allows for the definition of custom laboratory value evaluation rules to enable automated and patientindividual value interpretation.
Computer model of oxygenation in neonates
Authors: Rafl Jakub , Huttova Veronika , Möller Knut , Bachman Thomas E. , Tejkl Leos , Kudrna Petr , Rozanek Martin , Roubik Karel 
Published: September 2019

Abstract
Maintaining a prescribed peripheral oxygen saturation (SpO2) target during routine care of neonates is challenging and inspired fraction of oxygen (FiO2) titration practices differ among caregivers and centers. Algorithms for automatic feedback control of SpO2 are being developed and tested, that would adapt to the changing neonatal organism and better maintain the required SpO2 target range. While clinical data is necessary to validate differences in the titration strategies, a continuous physiological model of oxygenation in neonates would facilitate baseline testing of different approaches, manual or automated. The objective of our study was to enhance a mathematical model of oxygenation of the neonate and to compare the performance of the model with available clinical data. We have implemented the diffusion resistance into the model as well as a variable oxyhemoglobin dissociation relationship and the bias between arterial and peripheral oxygen saturation. Values of model parameters were scaled to fit preterm infant scenarios. The comparison of the clinical data and computer simulations suggest that the model can reliably simulate episodes of oxygen desaturation and describe the relation between ventilation, FiO2and SpO2. It appears that the model may be an effective tool to test manual and automatic FiO2titration strategies.