bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study on the Influence of Supplementary Cementitious Materials on Marine Concrete
Authors: Li Xiaosheng , Shui Zhonghe , Huang Yun , Gao Xu , Chen Jie 
Published: August 2019

Abstract
In this study, the influences of fly ash, ground granulated blast furnace slag (GGBS), silica fume (SF), and metakaolin (MK) on seawater resistance of cement-based materials are investigated and compared. The obtained results revealed that calcium hydroxide and ettringite (AFt) in matrix are dissolved completely during seawater immersion, whereas Friedel’s salt and brucite are deposited in pores. Seawater corrosion enlarges the capillary pores, increasing the critical pore size and capillary pore volume, resulting in decreased permeability of the matrix. SF and MK effectively contribute to pore refinement and exhibit less water-induced degradation at the early stage. GGBS and MK possess active aluminum, which transforms into AFt during interactions with seawater. Employment of MK maintains the stability of ettringite to some degree.
A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination
Authors: Yan Yi-Lin , Batzel Peter , Titus Tom , Sydes Jason , Desvignes Thomas , BreMiller Ruth , Draper Bruce , Postlethwait John H 
Published: August 2019

AbstractAnti-Mullerian hormone (Amh) inhibits female reproductive duct development, signals oocyte reserve, and marks polycystic ovarian syndrome. Zebrafish lacks Mullerian ducts and the typical Amh receptor, questioning evolving roles of Amh. Yan et al. made knockout mutations in zebrafish...Fetal mammalian testes secrete Anti-Müllerian hormone (Amh), which inhibits female reproductive tract (Müllerian duct) development. Amh also derives from mature mammalian ovarian follicles, which marks oocyte reserve and characterizes polycystic ovarian syndrome. Zebrafish (Danio rerio) lacks Müllerian ducts and the Amh receptor gene amhr2 but, curiously, retains amh. To discover the roles of Amh in the absence of Müllerian ducts and the ancestral receptor gene, we made amh null alleles in zebrafish. Results showed that normal amh prevents female-biased sex ratios. Adult male amh mutants had enormous testes, half of which contained immature oocytes, demonstrating that Amh regulates male germ cell accumulation and inhibits oocyte development or survival. Mutant males formed sperm ducts and some produced a few offspring. Young female mutants laid a few fertile eggs, so they also had functional sex ducts. Older amh mutants accumulated nonvitellogenic follicles in exceedingly large but sterile ovaries, showing that Amh helps control ovarian follicle maturation and proliferation. RNA-sequencing data partitioned juveniles at 21 days postfertilization (dpf) into two groups that each contained mutant and wild-type fish. Group21-1 upregulated ovary genes compared to Group21-2, which were likely developing as males. By 35 dpf, transcriptomes distinguished males from females and, within each sex, mutants from wild types. In adult mutants, ovaries greatly underexpressed granulosa and theca genes, and testes underexpressed Leydig cell genes. These results show that ancestral Amh functions included development of the gonadal soma in ovaries and testes and regulation of gamete proliferation and maturation. A major gap in our understanding is the identity of the gene encoding a zebrafish Amh receptor; we show here that the loss of amhr2 is associated with the breakpoint of a chromosome rearrangement shared among cyprinid fishes.
Privatautonomie im Bereich des Commercial Banking
Authors: Piekenbrock Andreas , Rodi Daniel 
Published: August 2019

Zusammenfassung
Der Beitrag bildet den Auftakt zu einer zweiteiligen Abhandlung über den Zustand der Privatautonomie im Bereich des Commercial Banking, insbesondere deren Einschränkung durch jüngere gesetzliche Neuregelungen sowie die Rechtsprechung des XI. Zivilsenats des BGH. Kernthema des ersten Teils sind die Abschluss- und die Beendigungsfreiheit, die im Hinblick auf den Kontrahierungszwang für Basiskonten nach dem Zahlungskontengesetz (§ 31 Abs. 1 ZKG) sowie das Pfändungsschutzkonto (§ 850k ZPO) untersucht werden. Hierbei erweist sich der Kontrahierungszwang nach dem ZKG trotz denkbarer alternativer Regelungsmodelle (Verpflichtung nur der Sparkassen) noch als verfassungsgemäß. Ferner zeigt sich, dass der in der Literatur geforderten verfassungskonformen Erweiterung der enumerativen Kündigungsgründe des Basiskontovertrags (§ 42 ZKG) um eine Kündigung aus wichtigem Grund das Unionsrecht entgegensteht. Die Vorschriften über das Pfändungsschutzkonto beeinträchtigen die privatautonome Möglichkeit zur Kündigung des zugrundeliegenden Girokontos hingegen richtigerweise nicht.
Datenverarbeitung durch Banken im Endkundengeschäft: Grundsätze, Forderungsabtretung und Scoring
Authors: Guggenberger Nikolas 
Published: August 2019

Zusammenfassung
Mit den allgegenwärtigen Datenverarbeitungsprozessen prägt die Datenschutz-Grundverordnung (DSGVO) die Rechtsverhältnisse von Banken im Endkundengeschäft. Dabei fordert das Autonomieverständnis der DSGVO eine Vielzahl bisheriger Annahmen grundlegend heraus. Dieser Beitrag befasst sich mit den Voraussetzungen der Rechtmäßigkeit der Datenverarbeitung und dem Einfluss des Datenschutzrechts auf das Bankgeheimnis, die Forderungsabtretung und das Scoring im Endkundengeschäft.
Basiszins: Vielfalt statt Einheit!
Authors: Knoll Leonhard , Kruschwitz Lutz , Löffler Andreas 
Published: August 2019

Zusammenfassung
Das IDW stellt bei seinen Vorgaben für die Ermittlung des Basiszinses in der Unternehmensbewertung grundsätzlich auf die NSS-Zinsstruktur der Deutschen Bundesbank ab, lässt aber neben der Verwendung periodenabhängiger Spot Rates auch einen einheitlichen Basiszins zu. Die folgende Studie zeigt, dass die in der Praxis dominierende Verwendung eines Einheitszinses eine systematische Verzerrung hervorruft, die bei normalen Kapitalmarktverhältnissen zu überhöhten Diskontierungszinsen und mithin zu reduzierten Unternehmenswerten führt. Damit erweist sich der Einheitszins zumindest bei rechtsgeprägten Unternehmensbewertungen als ungeeignet und sollte nicht mehr eingesetzt werden.
Export Diversification and Economic Growth in Nigeria
Authors: Nwosa Philip Ifeakachukwu , Tosin Fasina Oluwadamilola , Ikechukwu Ogbuagu Matthew 
Published: August 2019

The issue of export diversification has been contentious in Nigeria due to the country’s unstable growth pattern which is majorly associated with instability in the international oil market and the poor performance of other sectors of the economy. Therefore, this study examines the link between export diversification and economic growth in Nigeria from 1962 to 2016. The study utilizes the Auto-regressive Distributed Lag (ARDL) technique. The result of this study shows that export diversification has a positive but insignificant influence on economic growth in Nigeria. The above result implies that the oil sector still dominates the Nigerian economy while the diversification drive of the government has not been significant in other sectors of the economy. Thus, the study recommends the need for conscious economic policies that would promote the diversification of the entire non-oil sector of the economy. The study concludes that export diversification is an insignificant determinant of economic growth in Nigeria.
Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas
Authors: Argadal Omer Gokay , Mutlu Melis , Ak Aksoy Secil , Kocaeli Hasan , Tunca Berrin , Civan Muhammet Nafi , Egeli Unal , Cecener Gulsah , Bekar Ahmet , Taskapilioglu Mevlut Ozgur , Tekin Cagla , Tezcan Gulcin , Tolunay Sahsine 
Published: August 2019

Primary glioblastoma (GB) is the most aggressive type of brain tumors. While mutations in isocitrate dehydrogenase (IDH) genes are frequent in secondary GBs and correlate with a better prognosis, most primary GBs are IDH wild-type. Recent studies have shown that the long noncoding RNA metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is associated with aggressive tumor phenotypes in different cancers. Our aim was to clarify the prognostic significance of MALAT1 in IDH1/2 wild-type primary GB tumors. We analyzed IDH1/2 mutation status in 75 patients with primary GB by DNA sequencing. The expression of MALAT1 was detected in the 75 primary GB tissues and 5 normal brain tissues using reverse transcription quantitative PCR (RT-qPCR). The associations between MALAT1 expression, IDH1/2 mutation status, and clinicopathological variables of patients were determined. IDH1 (R132H) mutation was observed in 5/75 primary GBs. IDH2 (R172H) mutation was not detected in any of our cases. MALAT1 expression was significantly upregulated in primary GB vs. normal brain tissues (p = 0.025). Increased MALAT1 expression in IDH1/2 wild-type primary GBs correlated with patient age and tumor localization (p = 0.032 and p = 0.025, respectively). A multivariate analysis showed that high MALAT1 expression was an unfavorable prognostic factor for overall survival (p = 0.034) in IDH1/2 wild-type primary GBs. High MALAT1 expression may have a prognostic role in primary GBs independent of IDH mutations.
Laparoscopic cervicopexy in uterine prolapse, a prospective study
Authors: Aliyar Anu , Palakkan Saphina , Vahab Abdul , P. Mumtaz 
Published: August 2019

Background: Pelvic organ prolapse is a common condition and a major cause of gynecological surgery. The lifetime risk of having an operation for prolapse may be 11%. Uterine conserving surgeries using synthetic mesh, especially in younger age group can restore normal anatomy relieving their pelvic symptoms. To evaluate the safety, intra operative and postoperative complications and efficacy of the laparoscopic cervicopexy.Methods: This Prospective observational study was carried out on women aged below 45 years attending gynaecology outpatient department with uterine prolapse at MES Medical College, Perinthalmanna between January 1st and December 31st, 2015. 39 women underwent laparoscopic cervicopexy and follow up assessments was done among them at 2 weeks, 3 months and 6 months. Results: The mean operative time was 27.6 minutes and blood loss was 0.4 gm/dl. No intraoperative and postoperative complications occurred. Short duration of hospital stay with mean of 1.4 days. 7.7% patients and 5.5% had mersilene tape reaction at 3 months and 6 months. The POP Q score C was significantly away from hymen at 2 weeks,3 months and 6 months (+4.4 - -4.3). 7.7% and 2.6% had recurrence at 3 month and 6 months. 5.1% underwent vaginal hysterectomy to get relieved from symptom.Conclusion: Laparoscopic cervicopexy is an effective option for women with pelvic organ prolapse who desire uterine preservation.
Maternal mortality and its causes in a tertiary care hospital
Authors: Doke Goter , Kamda Jyoti 
Published: August 2019

Background: Maternal mortality is defined as the death of a woman while being pregnant or within 42 completed days of termination of pregnancy. The aim of this study was to study the maternal mortality and analyze the complications leading to maternal deaths.Methods: A retrospective study of hospital records and death summaries of all maternal deaths over the period of two year from April 2017 to March 2019 was conducted in the Department of Obstetrics and Gynecology, Tomo Riba Institute of Health and Medical Science, a tertiary level healthcare referral center in Naharlagun, Arunachal Pradesh, India.Results: There was a total of 6 maternal deaths out of 6311 live births giving maternal mortality ratio (MMR) of 95.07 per 1,00,000 live births. The majority of deaths were reported in the age groups 30-40 years (66.66%). More deaths were reported in multiparous women (83.33%) as compared to primiparous women (16.66%). Most of them were unbooked cases (66.66%). Haemorrhage (33.33) and pregnancy induced hypertension (33.33%) were the major direct cause of maternal deaths.Conclusions: Haemorrhage and pregnancy induced hypertension were found to be major cause of maternal deaths. In our study, there was no maternal death from anemia and other medical disorder.
Stress and emotion regulation in resident doctors at a tertiary care hospital of North India
Authors: Singh Chitvan , Singh Udeyana , Soni Anshu , Verma Rohit 
Published: August 2019

Background: The stress of medical training stems from academic pressure, exhausting work hours and striving for perfectionist standards. The demanding nature also requires involvement with emotionally draining aspects of life (human suffering, death, sexuality and fear). This may impair quality of life of medical students and influence patient care. As a consequence, post graduate medical students can experience an alarming amount of stress-associated anxiety, depression, substance abuse, and even suicide. Chronic stress is also known to influence memory, learning and especially problem-solving abilities which require flexible thinking. The study was carried out to evaluate the relationship of stress to cognitive reappraisal and emotion suppression in post graduate medical students. Methods: 150 post graduate medical students participated in the study. Emotion Regulation Questionnaire and Professional Life Stress Questionnaire were administered on each participant. Data collected was kept confidential. Results were tabulated and statistically analysed.Results: Out of 150 participants, 85 (56.67%) experienced stress. 65 (43.33%) participants had stress in the moderate range, 20 (13.33%) participants had stress in the problematic area for whom remedial action was required. 52% showed high cognitive reappraisal, while 54% showed emotional suppression.Conclusions: The correlation between stress, cognitive reappraisal and between stress, emotion suppression showed weak strengths.
Quality of life at six months after primary percutaneous coronary intervention performed at a predominantly rural population
Authors: Mujtaba Syed Fayaz , Sial Jawaid Akbar , Shaikh Sajid Ali , Naeem Muhammad , Soomro Imran , Karim Musa , Abbas Kiran , Ahmed Moiz , Hussain Kanza Abid 
Published: August 2019

Background: HRQL is important in improving the quality of patient care. However, there is a paucity of data from low-income and middle-income countries (LMIC). Differences in socio-demographics and socio-cultural contexts may influence HRQOL. Therefore, this research was designed with the aim to explore the HRQOL in patients after Percutaneous Coronary Intervention (PCI).Objective: The goal of the study was to evaluate the quality of life after six months of Percutaneous Coronary Intervention using HeartQol questionnaire at a tertiary care hospital in Pakistan.Method: This was a Cross-sectional, descriptive study. Patients between the ages of 20-60 years who underwent primary Percutaneous Coronary Intervention at least 6 months ago were inducted in the study. Coronary angiography was performed mostly through radial as preferred route. Data was collected using a structured questionnaire covering demographic characteristics, predisposing risk factors, procedural details, and quality of life. Heart related Quality of life was assessed using HeartQol questionnaire. Collected data was analyzed using SPSS v.21.Results: A total of 241 patients participated in the study. Mean age of the patients was 53.37±11.07 years. On analysis of quality of life at six months, the median (IQR) HeartQol score was 31 (37-23) with majority of the patients, 84.22% (203) fall under the excellent score (>20).Conclusion: It is of enormous prognostic importance that the quality of life of patient is assessed on a regular basis after PCI. Our study shows that the majority of patients had improved quality of life at six months of PCI. Majority of patients were not bothered by mild symptoms. Further investigation needs to be done to validate these results.
Screening of type 2 diabetes mellitus patients for their macrovascular complications in tertiary care hospital
Authors: B. Ragul , K. Kiran P. , Gupta A. K. 
Published: August 2019

Background: Type2 diabetes is characterized by a long asymptomatic period commonly to be diagnosed when complications appear. The risk factors associated with diabetes are age, hypertension, dyslipidemia, smoking, alcohol, obesity & others. The role of early detection and adequate treatment of diabetes and related complications patients and health services is the basis for present study.Methods: The present study was conducted at S.N. Medical College, Agra, India on 86 consecutive newly diagnosed cases of type 2 diabetes. All individuals aged ≥ 20 years of age, who were not known diabetic, presenting to medicine department were included in the study for the targeted and opportunistic screening duration of January 2011 to June 2012.Results: The prevalence rates of vascular complications in this study group were analyzed statistically. The findings are the mean age was 54.27±9.27 years. 72.09% of newly diagnosed type 2 diabetes patients were aged above 50 years. Maximum number of patients were overweight (37.20%) followed by obese (32.55%). Hypertension was present in 30.23%, prevalence of CAD was 9.30%, and none had evidence of PVD and Cerebrovascular disease.Conclusions: Macrovascular complications were present in 9.30% of asymptomatic newly diagnosed type 2 diabetes patients. In the study present study found that there was a significant association of these risk factors were identified and treated as early as possible to decrease the progression of vascular complications.
Impact of the Transfersome Delivered Human Growth Hormone on the Dermal Fibroblast Cells
Authors: Azimi Minoo , Khodabandeh Mahvash , Deezagi Abdolkhalegh , Rahimi Fatemeh 
Published: August 2019

Objective:
Transfersomes are highly flexible vesicles that are capable of passing through
pores smaller than their own sizes due to their elastochemical characteristics, and thus play a key role
in drug delivery to the skin.

Methods:
In this study, we used transdermal delivery of growth hormone-encapsulated transferosomes
(F1 and F2) as antiaging strategy, with the resulting effects being subsequently evaluated. The size,
distribution and zeta potential of the particles, together with the in vitro skin permeation and biological
activity of the growth hormone loaded onto the transfersomes were measured.

Results:
The data demonstrated that treatment of fibroblasts with encapsulated hGH increased cell migration,
proliferation and collagen I and III gene expression. According to our results, the maximum
amount of growth hormone that passes through the skin during a 24 h time period was 489.54 and
248.46 ng/cm3, for the F1 and F2 transfersomes, respectively. In addition, it was determined that F1
formula as the more efficient carrier, showed no toxicity against cells. With regard to fibroblasts, as
one of the most important cells involved in collagen synthesis, skin aging and wound healing, concentrations
of growth hormone encapsulated in transferosomes that had an effect on fibroblast growth and
division, were determined. The results demonstrated that effective concentrations of the encapsulated
growth hormone increased the expression of collagen I and collagen III genes.

Conclusion:
Furthermore, analyzing the rate of fibroblast cell migration showed that migration increased
significantly at 700 ng/ml growth hormone concentrations, as compared to that of the control.
Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak
Authors: Zhao Wangsheng , Mengal Kifayatullah , Yuan Meng , Quansah Eugene , Li Pengcheng , Wu Shixin , Xu Chuanfei , Yi Chuanping , Cai Xin 
Published: August 2019

Background:Cattleyak are the Fl hybrids between (♀) yak (Bos grunniens) and (♂) cattle (Bos taurus). Cattleyak exhibit higher capability in adaptability to a harsh environment and display much higher performances in production than the yak and cattle. The cattleyak, however, are females fertile but males sterile. All previous studies greatly focused on testes tissues to study the mechanism of male infertility in cattleyak. However, so far, no transcriptomic study has been conducted on the epididymides of yak and cattleyak.Objective:Our objective was to perform comparative transcriptome analysis between the epididymides of yak and cattleyak and predict the etiology of male infertility in cattleyak.Methods:We performed comparative transcriptome profiles analysis by mRNA sequencing in the epididymides of yak and cattleyak.Results:In total 3008 differentially expressed genes (DEGs) were identified in cattleyak, out of which 1645 DEGs were up-regulated and 1363 DEGs were down-regulated. Thirteen DEGs were validated by quantitative real-time PCR. DEGs included certain genes that were associated with spermatozoal maturation, motility, male fertility, water and ion channels, and beta-defensins. LCN9, SPINT4, CES5A, CD52, CST11, SERPINA1, CTSK, FABP4, CCR5, GRIA2, ENTPD3, LOC523530 and DEFB129, DEFB128, DEFB127, DEFB126, DEFB124, DEFB122A, DEFB122, DEFB119 were all downregulated, whereas NRIP1 and TMEM212 among top 30 DEGs were upregulated. Furthermore, protein processing in endoplasmic reticulum pathway was ranked at top-listed three significantly enriched KEGG pathways that as a consequence of abnormal expression of ER-associated genes in the entire ER protein processing pathway might have been disrupted in male cattleyak which resulted in the downregulation of several important genes. All the DEGs enriched in this pathway were downregulated except NEF.Conclusion:Taken together, our findings revealed that there were marked differences in the epididymal transcriptomic profiles of yak and cattleyak. The DEGs were involved in spermatozoal maturation, motility, male fertility, water and ion channels, and beta-defensins. Abnormal expression of ERassociated genes in the entire ER protein processing pathway may have disrupted protein processing pathway in male cattleyak resulting in the downregulation of several important genes involved in sperm maturation, motility and defense.
Jackfruit (Artocarpus heterophyllus): A Comprehensive Patent Review
Authors: Mandhare Anita , Banerjee Paromita , Pande Archana , Gondkar Anita 
Published: August 2019

Background:
Jackfruit (Artocarpus heterophyllus) having an impressive array of nutrients
is one of the potential functional foods being studied by the researchers worldwide in recent times.
While the ancient fruit is widely consumed as fresh fruit, its other parts are reported for their diverse
therapeutic activity as an antioxidant, anti-inflammatory, anti-microbial, anti-cancer, anti-fungal,
anti-bacterial, anti-diabetic, and as immune-modulator.

Methods:
An extensive search was conducted to review the patent information on jackfruit and its
bioactive constituents using various patent databases spanning all priority years till date.

Results:
Analysis of the patent data reveals that jackfruit and its bioactive constituents find application
in diverse industries such as pharmaceuticals, cosmeceuticals, food including beverages and
nutraceuticals, as well as agrochemicals, plant breeding and in the paper industry. Approximately
twenty-three patents are identified which focus on the treatment of various therapeutic conditions,
and another fifteen patents disclose the use of jackfruit as an ingredient in cosmetic compositions.
The review also includes the clinical studies of the drugs containing natural actives that can be
isolated from the jackfruit tree.

Conclusion:
The detailed research on the patent information presented herein focused on the activity
of the compositions containing jackfruit extract and isolated phytochemicals would assist researchers
to understand the mechanisms by which the bio-chemicals exert their effect and the overall nutritional
benefits. An increase in the number of publications and patents in recent years related to the use of
jackfruit for different health conditions clearly emphasizes its therapeutic potential and importance as
medicinal food products and cosmetics.