bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐paced English as a Foreign Language in a Competency Based Education program for Korean learners
Authors: Vail Timothy 
Published: July 2019

AbstractIntroductionThis research project is an action research investigation into the breadth and effectiveness of self‐paced study in comparison with traditional fixed‐paced learning in the researcher's instructional environment and self‐owned English language institute.BackgroundThere were nine South Korean English as a Foreign Language (EFL) adult students who participated in the study and who were previously enrolled in the school to improve their English conversational ability.MethodsThe nine students were split into two groups of self‐ and fixed‐paced study using a Competency Based Education (CBE) model, and the instruction covered the exact same material and competencies in both classes. From those students, mixed data (both quantitative and qualitative) were gathered both before and after instruction, as well as some observation in the middle of the lessons. The study measured the performance differences as well as the range of benefits received due to each program methodology.ResultsThe resulting data demonstrated that students who were underperforming their peers in the fixed‐paced study improved and outperformed their peers after taking a self‐paced program and could answer on average 20% more accurately on questions posed to them about the material and about themselves in English. They also displayed a number of other benefits to their learning including confidence, quantity of learned material, and better time management and flexibility.DiscussionAlthough the sample size was too small to draw conclusions for other populations, this pilot study confirmed for this population that self‐paced study was more beneficial and led to the Institute discontinuing the fixed‐pace program altogether.
Short‐term clinical outcomes of percutaneous coronary intervention of unprotected left main coronary disease in cardiogenic shock
Authors: Castro‐Mejía Alex F. , Ortega‐Armas María E. , Mejía‐Rentería Hernán , Gonzalo Nieves , Salinas Pablo , Nombela‐Franco Luis , del Trigo María , Jiménez‐Quevedo Pilar , Escaned Javier , Fernández‐Ortiz Antonio , Macaya Carlos , Nuñez‐Gil Iván J. 
Published: July 2019

AbstractBackgroundPercutaneous coronary intervention (PCI) of left main (LM) disease in patients with cardiogenic shock (CS) represents a clinical challenge. Evidence on clinical outcomes according to revascularization strategies in this scenario remains scarce. The objective was to investigate the short‐term outcomes according to treatment strategies for this population.MethodsWe retrospectively analyzed 78 consecutive patients who underwent PCI of LM in established CS at two experienced centers. Characteristics of PCI and short‐term clinical outcomes were assessed.ResultsLM stenosis was considered the culprit lesion in 49 patients (62.8%). In the remaining cases, LM stenosis was treated after successful PCI of the culprit vessel because of persistent CS. The majority of patients presented complex coronary anatomy (43.6% had Syntax score > 32). Complete revascularization was performed in 34.6%; a 2‐stents technique in the LM bifurcation was used in 12.8% and intra‐aortic balloon pump (IABP) in 73.1%. In‐hospital mortality was 48.7%. At 90 days follow‐up it was 50% without differences between 1 or 2 stent LM bifurcation‐techniques (p = .319). Mortality was higher in patients with partial revascularization and residual Syntax score ≥ 15 (p < .05 by univariate analysis), and in those with TIMI flow<3 in the left coronary artery at the end of PCI (p < .05 by multivariate analysis). There were no significant differences in the use of IABP in relation to 90‐day mortality (p = .92).ConclusionsIn patients presenting with cardiogenic shock and LM disease, neither 2‐stents strategy in the LM nor use of IABP displayed a reduced short‐term mortality. However, patients with final TIMI flow <3 presented higher short‐term mortality in our series.
Gaucher disease type 1 first recognized in an elderly patient with thrombocytopenia and lung adenocarcinoma
Authors: Shuai Wen , Wagner Celeste Estefania , Sukswai Narittee , Medeiros L. Jeffrey , Bueso‐Ramos Carlos , Oo Thein Hlaing 
Published: July 2019

AbstractRecognizing Gaucher disease in elderly patients can be challenging. We present a Gaucher disease type 1 case diagnosed in an elderly patient with thrombocytopenia and lung adenocarcinoma. The diagnosis of Gaucher disease was delayed due to lack of familiarity about Gaucher Disease type 1 which can manifest in adulthood.
Intentional acetylsalicylic acid acute intoxication and its clinical management
Authors: Soleimani Reza , Brousmiche Karl , Favresse Julien , Haufroid Vincent , Gruson Damien , Hantson Philippe , Wallemacq Pierre 
Published: July 2019

AbstractIn the last decade, our knowledge about OTC drug intoxication has been expanded much further relative to previous years, though the absence of antidotes in some cases results in healthcare professionals using symptomatic treatment. This case report reminds the reader of the importance of clinical and toxicology laboratories in the management of acute salicylate intoxication in order to avoid hemodialysis.
A Novel Method to Fabricate Nitrogen and Oxygen Co‐Doped Flexible Cotton‐Based Electrode for Wearable Supercapacitors
Authors: Sun Chao , Zhao Jing , Guo Zhiguang , Zhao Yaping , Cai Zaisheng , Ge Fengyan 
Published: July 2019

AbstractIn this work, we prepared a nitrogen and oxygen co‐doped flexible cotton‐based carbon electrode with high electrochemical performance by using a simple dyeing and carbonization method for its potential application in wearable energy storage devices. The optimized dyed cotton‐based electrode with 10 % o.w.f. (percentage on weigh of fabric) dyeing concentration shows a high areal specific capacitance of 1836±20 mF cm−2 at 2 mA cm−2 in aqueous 6 M KOH, superior cycling lifespan (99.1 % capacitance retention after 5000 cycles), good coulombic efficiency, and high rate property. The outstanding properties can be attributed to the synergistic effect between the double‐layer capacitance (superior conductivity, large surface area, and good wetability) and the extra pseudocapacitance originating from N and O heteroatoms in the dye molecules. More importantly, the symmetric supercapacitor created with CDF‐10 % electrodes exhibits a significant volumetric specific capacitance of 18.2 F cm−3 and energy density of 5.7 mWh cm−3 at a power density of 45.2 mW cm−3, which can power an electronic clock for several minutes. The impressive resulting performance demonstrates that this inexpensive synthetic method, which can be scaled‐up, can be used to create promising materials for wearable electronics.
Simultaneous determination of food colorants in liquid samples by UV‐Visible spectroscopy and multivariate data analysis using a reduced calibration matrix
Authors: Bordagaray Ane , Dávila Sergio , Garcia‐Arrona Rosa , Vidal Maider , Ostra Miren 
Published: July 2019

AbstractColorants are widely used in food industry to improve appearance of edible products. This work present a method for the determination of two colorants, tartrazine and allura red, with UV‐Vis spectrophotometry and MCR‐ALS using only five standards for calibration and the correlation constraint. MCR‐ALS is usually applied in second‐order data but it rarely has been used for first order data, for which is more usual the use of PLS. In this case, MCR‐ALS applied to first order data can show some advantages like interference identification and the use of a reduced calibration matrix. Using this methodology, the relative errors obtained are below 0.28%, correlation coefficients are above 0.99 and the calculated LOD and LOQ are 0.26 and 0.80 mg L‐1 for allura red and 0.70 and 2.11 mg L‐1 for tartrazine respectively. The procedure has been successfully applied to some food dyes and other liquid commercial products and, compared to HPLC analysis, no significant differences were found in the results. Recovery values obtained at two spiked levels were between 92.0% and 106.7% except for a sample.
Synergy of Electron Transfer and Charge Transfer in the Control of Photodynamic Behavior of Coordination Polymers
Authors: Yang Xiao‐Dong , Zhu Rui , Yin Jian‐Ping , Ma Shuai , Cui Jing‐Wang , Zhang Jie 
Published: July 2019

AbstractPhotodynamic behavior controlled by the synergy of electron transfer and charge transfer has been characterized in two regioisomeric pyridinium‐bearing coordination polymers (Cd‐Bip and Cd‐Bpy) with the help of a smart charge‐distribution‐related isoreticular strategy. Because it is relatively weak, the charge‐transfer interaction between adjacent 2D networks in Cd‐Bip can be easily perturbed by photoinduced electron transfer under irradiation with 365 nm light, and then successfully drives the occurrence of photodynamic behavior. In contrast, lower energy 450 nm light is absorbed to a lesser extent, and can only induce a low degree of electron transfer, which is insufficient to actuate operation of this photodynamic behavior in Cd‐Bip.
Reactivity of a Sterically Unencumbered α‐Borylated Phosphorus Ylide towards Small Molecules
Authors: Radius Michael , Sattler Ewald , Berberich Helga , Breher Frank 
Published: July 2019

AbstractThe influence of substituents on α‐borylated phosphorus ylides (α‐BCPs) has been investigated in a combined experimental and quantum chemical approach. The synthesis and characterization of Me3PC(H)B(iBu)2 (1), consisting of small Me substituents on phosphorous and iBu residues on boron, is reported. Compound 1 is accessible through a novel synthetic approach, which has been further elucidated through DFT studies. The reactivity of 1 towards various small molecules was probed and compared with that of a previously published derivative, Ph3PC(Me)BEt2 (2). Both α‐BCPs react with NH3 to undergo heterolytic N−H bond cleavage. Different di‐ and trimeric ring structures were observed in the reaction products of 1 with CO and CO2. With PhNCO and PHNCS, the expected insertion products [Me3PC(H)(PhNCO)B(iBu)2] and [Me3PC(H)(PhNCS)B(iBu)2], respectively, were isolated.
Investigation of combustion reactivity and NO emission characteristics of chars obtained from the devolatilization of raw and partially dried lignite
Authors: Zhao Yaying , Wang Zhuozhi , Zhao Guangbo , Sun Rui , Ren Xiaohan 
Published: July 2019

AbstractIn an attempt to achieve the clean and efficient utilization of lignite, drying pre‐treatment was performed in this study before lignite combustion. The combustion reactivity and NO emission characteristics of the partially dried lignite samples in the char combustion stage were investigated by means of TG and isothermal combustion tests, and the reactivity could be summarized as the following order: L1>L0.5>raw>L3>LT>L5 (chars obtained from the devolatilization of the raw and partially dried coals at 378 K for 0.5, 1, 3, 5, and 120 minutes) and the NO conversion ratio of L1 was the lowest. When the moisture content in the coal particles was relatively high (19.68%‐35.84%), the drying treatment could increase the combustion reactivity and inhibit NO emission in the char combustion stage; When the moisture content was within a relatively low range (0.17%‐19.68%), the moisture removal had negative effects on the reactivity and NO emission in the char combustion stage. The surface behaviour and microstructure of the raw coal char and chars derived from the partially dried coals were clarified by temperature programmed desorption/reduction (TPD/TPR) and Raman spectroscopy. The results illustrated that L1 derived from Lc1 (19.68%) was the most reactive sample with the largest amount of C(O) on the particle surface. There were also more reactive aromatic structures in L1 than other samples. Compared with direct combustion or excessive drying treatment, lignite should be dried to a certain degree (19.68%) for optimized lignite combustion.
Surgical excision, Mohs micrographic surgery, external‐beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta‐analysis of 58 studies with 21,000 patients
Authors: Lee Charles T. , Lehrer Eric J. , Aphale Abhishek , Lango Miriam , Galloway Thomas J. , Zaorsky Nicholas G. 
Published: July 2019

BackgroundThe objective of this study was to compare the cosmesis and recurrence rates of conventional excision (CE), Mohs micrographic surgery (MMS), external‐beam radiation therapy (EBRT), or brachytherapy (BT), for basal cell carcinoma and squamous cell carcinoma of the skin.MethodsPopulation, Intervention, Control, Outcome, Study Design (PICOS), Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), and Meta‐Analyses of Observational Studies in Epidemiology (MOOSE) methods were used to identify studies on PubMed (from 1985 to 2018), including patients with American Joint Committee on Cancer (AJCC) T1‐T2N0 basal cell carcinomas and squamous cell carcinomas and ≥10 months follow‐up who received CE, MMS, EBRT, or BT. The primary endpoint was cosmesis, classified as “good,” “fair,” or “poor.” The secondary endpoint was 1‐year recurrence. Fixed‐effects and random‐effects meta‐analyses were performed to evaluate primary and secondary outcomes with respect to treatment modality.ResultsIn total, 18,095 studies met initial search criteria. There were 24 CE, 13 MMS, 19 EBRT, and 7 BT studies included with a total of 21,371 patients. The summary effect size for “good” cosmesis was 81% (95% CI, 70.6%‐89.6%), 74.6% (95% CI, 63%‐84.6%), and 97.6% (95% CI, 91.3%‐100%) for CE, EBRT, and BT, respectively. Good cosmesis was 96.0% in the only MMS study that reported cosmesis. BT had improved “good” cosmesis over EBRT (P = .0025) and was similar to CE and MMS. No significant differences were seen for “fair” or “poor” cosmesis. One‐year recurrence rates were low throughout at 0.8% (95% CI, 0.3%‐1.6%), 0.2% (95% CI, 0%‐0.6%), 2% (95% CI, 1.3%‐2.7%), and 0% (95% CI, 0%‐0.5%) for CE, MMS, EBRT, and BT, respectively.ConclusionsFor T1‐T2N0 skin cancers, BT and MMS have improved cosmesis over EBRT and CE. It is unclear whether this is because of treatment superiority or selection and reporting bias. Local control is similar among all modalities at 1 year.
Challenges and opportunities for the simulation of calcium waves on modern multi‐core and many‐core parallel computing platforms
Authors: Barajas Carlos , Gobbert Matthias K. , Kroiz Gerson C. , Peercy Bradford E. 
Published: July 2019

AbstractState‐of‐the‐art distributed‐memory computer clusters contain multicore CPUs with 16 and more cores. The second generation of the Intel Xeon Phi many‐core processor has more than 60 cores with 16 GB of high‐performance on‐chip memory. We contrast the performance of the second‐generation Intel Xeon Phi, code‐named Knights Landing (KNL), with 68 computational cores to the latest multicore CPU Intel Skylake with 18 cores. A special‐purpose code solving a system of nonlinear reaction‐diffusion partial differential equations with several thousands of point sources modeled mathematically by Dirac delta distributions serves as realistic test bed. The system is discretized in space by the finite volume method and advanced by fully implicit time‐stepping, with a matrix‐free implementation that allows the complex model to have an extremely small memory footprint. The sample application is a seven variable model of calcium‐induced calcium release (CICR) that models the interplay between electrical excitation, calcium signaling, and mechanical contraction in a heart cell. The results demonstrate that excellent parallel scalability is possible on both hardware platforms, but that modern multicore CPUs outperform the specialized many‐core Intel Xeon Phi KNL architecture for a large class of problems such as systems of parabolic partial differential equations.
Tracking Dye‐Independent Approach to Identify and Isolate In Vitro Expanded T Cells
Authors: Elias George , Ogunjimi Benson , Van Tendeloo Viggo 
Published: July 2019

SummaryT cell proliferation is routinely identified in vitro using tracking dyes or through detecting intracellular upregulation of the nuclear protein, Ki‐67. However, labeling with tracking dyes is cumbersome, associated with cellular toxicity, while Ki‐67 cannot be used to identify and isolate viable T cells, and both techniques are incompatible with MACS technology. Here, we introduce a simple tool to identify and isolate in vitro T cell expansion that is tracking dye‐independent and allows for sorting of viable T cells. We show that CD71, a transferrin receptor, and CD98, a heterodimer glycoprotein involved in both integrin signaling and amino‐acid transport, are both highly upregulated on proliferating T cells upon in vitro stimulation, and that CD71 expression is maximal on the more recent progeny T cells, while CD98 upregulation remains stable across different generations of progeny T cells. Moreover, we demonstrate that the upregulation of CD71 and CD98 identifies CFSElow T cells and provides further proof of the antigen‐specificity of T cells identified by CD71 and CD98 dual upregulation based on tetramer staining. We further show that CD71 can be used to enrich for in vitro expanding T cells using MACS technology. In conclusion, we show that CD71 and CD98 can be used to identify and isolate expanded T cells following in vitro stimulation and that CD71 is an MACS‐compatible alternative to tracking dyes or Ki‐67 detection. © 2019 International Society for Advancement of Cytometry
Cytology with rapid on‐site examination (ROSE) does not improve diagnostic yield of EUS‐FNA of pancreatic cystic lesions
Authors: Estrada Paul , Benson Mark , Gopal Deepak , Buehler Darya , Pfau Patrick 
Published: July 2019

AbstractBackgroundCytology with rapid on‐site evaluation (ROSE) has been shown to increase the diagnostic accuracy of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) for solid pancreatic lesions. No data exists on the need for rapid onsite cytology in the evaluation of pancreatic cystic lesions (PCLs). The purpose of this study is to determine whether onsite cytology impacts the diagnostic yield of EUS‐FNA of PCLs.MethodsWe prospectively examined all patients with PCLs who underwent EUS‐FNA without onsite cytology over a 6‐month period and compared this to a historical cohort of patients with PCLs who underwent EUS‐FNA with ROSE in the previous 6 months. Comparison was made between the two groups based upon patient demographics, EUS cyst characteristics, and FNA fluid & cytopathology results.ResultsA total of 100 EUS‐FNA exams for PCLs were identified: 46 with ROSE and 54 without onsite cytology. The majority of cytology findings were negative or nondiagnostic, 87.0% in the ROSE group, 77.8% in the group without onsite cytology. There was no difference using EUS‐FNA without onsite cytology compared to ROSE when measuring total diagnostic yield (22.2% vs 13.0%, P = .30), number of nondiagnostic specimens (50% vs 54%, P = .69), and number of needle passes (1.51 vs 1.57, P = .68).Conclusions(a) The majority of cytology results from EUS‐FNA of cystic lesions are negative or nondiagnostic. (b) Having rapid onsite cytology evaluation of cystic lesions does not affect the number of needle passes nor diagnostic yield and is thus not recommended.
Nornostocine congeners as potential anticancer drugs: An overview
Authors: Sahoo Chita R. , Paidesetty Sudhir K. , Padhy Rabindra N. 
Published: July 2019

AbstractThe naturally occurring phyco‐constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with a remarkable anticancer activity. This review summarizes the chemistry of numerous synthetic strategies of demethylated nostocine as “nornostocine derivatives,” in which the substitutes are connected to a few functionalities with the pyrazolotriazine moiety at N‐1, C‐3, and C‐5 positions. These strategies may provide a framework to design and develop a novel potent anticancer drug candidate(s) with an augment of structure activity relationship related to anticancer activities.
Stand inventory data from the 10‐ha forest research plot in Uholka: 15 yr of primeval beech forest development
Authors: Stillhard Jonas , Hobi Martina , Hülsmann Lisa , Brang Peter , Ginzler Christian , Kabal Myroslav , Nitzsche Jens , Projer Gilbert , Shparyk Yuriy , Commarmot Brigitte 
Published: July 2019

AbstractForests dominated by European beech (Fagus sylvatica L.) are among both the most widespread in Europe and the most intensely exploited globally. One of the largest remnants of unmanaged beech forests in Europe is the Uholka‐Shyrokyi Luh forest in Transcarpathia, Ukraine, covering 8,800 ha of primeval forest. In 2000, a permanent forest plot of 10 ha has been established in the Uholka massif. All living and dead trees with a diameter at breast height (DBH) ≥ 60 mm were identified to species, DBH measured, stems tagged and mapped. Since then, the plot has been remeasured in 2005, 2010, and 2015. In total, 4,820 individual trees were measured with 14,116 individual measurements throughout all four inventories. In spring 2018, an Airborne Laser Scan was carried out, covering the Uholka‐Shyrokyi Luh forest. This data set allows us to derive a high‐resolution digital elevation model (DEM) of the plot area. European beech covers a share of ≈ 95% of the basal area (BA) of all living stems. While BA was relatively stable throughout all inventories (≈ 38 m2/ha), the number of stems increased considerably between 2010 and 2015 from 290 to 430 stems/ha. Additionally, the proportion of beech stems decreased from 95% in 2010 to 86% in 2015. The continuity of the share of beech on BA and the decrease in number of stems can be traced back to disturbance events, which led to an increase of more light demanding species in the recruitment but did not alter the distribution of BA as these small trees contribute very little to BA. The data set allows for important insights into the development and the spatial and temporal dynamics of primeval beech forests. It can be used to quantify the demographic processes growth, mortality, and recruitment, and to study inter‐ and intraspecific effects on demographic rates, stand structure, and species composition. No copyright or proprietary restrictions are associated with the use of this data set other than citation of this Data Paper.