bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the FAP-Targeted Therapeutics for Adrenocortical Carcinoma
Authors: Chopra Sejal , Walia Rama , Kaur Komalpreet , Roesch Frank , Moon Euy Sung , Mittal Bhagwant Rai , Shukla Jaya 
Published: November 2024

Abstract
Metastatic or recurrent adrenocortical carcinoma is a potentially lethal malignancy, presenting significant challenges in disease management owing to absence of effective systemic treatments. Significantly diminished survival rates necessitate rapid identification of specific molecules for the development of targeted therapeutics. Fibroblast activation protein (FAP)–expressing cancer-associated fibroblasts have been a major breakthrough causing a paradigm shift in targeted theranostics focusing on the tumor microenvironment. The effectiveness of various FAP inhibitors (FAPis) and FAP targeting peptide has been extensively documented in diverse clinical investigations. We have evaluated 3 molecules, that is, DOTA.SA.FAPi (SA.FAPi), FAPi46, and FAP2286, as potential theranostic probes for adrenocortical carcinoma.
Interdisciplinary Operating Room Ergonomics Needs and Priorities
Authors: Mah Alexis , Alam Fahad , Larouche Jeremie , Dandal Marie-Antonette , Cohen Tara , Hallbeck Susan , Norasi Hamid , Kallocsai Csilla , Sriram Sapna , Helman James D. , Hallet Julie 
Published: November 2024

Objective:
To examine perceived OR ergonomics facilitators and barriers, with a focus on the interdisciplinary team.

Summary Background Data:
Poor ergonomics causes musculoskeletal injuries affecting all operating room (OR) staff with repercussions on patient care, outcomes, and sustainability. Lack of ergonomic awareness and education are risk factors.

Methods:
We conducted a self-administered web-based survey of OR nurses, surgeons, and anesthesiologists at a single centre (n=238). We developed a questionnaire through items generation and reduction, followed by reliability and validity testing.

Results:
Response rate was 53.8%. Respondents perceived that on average 80% of nurses, 70% of surgeons, and 40% anesthesiologists experienced MSK injuries, with no difference in professional groups’ perceptions. Guideline ergonomics interventions were rarely used (<25%) except for specialized clothing (33%), equipment repositioning (59%), and seating (37%), though perceived beneficial by 80-90%. Reported barriers to optimal ergonomics were organizational/structural (lack of time, space, equipment, funding), whereas solutions were individual. Fear of unfavourable perception from others was a concern for 62%. Teams discussing, prioritizing, monitoring, or helping with ergonomics was indicated by <50%. Individual ergonomic adaptations were perceived as convenience by other staff.

Conclusions:
While structural/organizational issues are reported as barriers to ergonomics, solutions appeared as individual responsibilities. Team dynamics did not prioritize nor support ergonomics. Education tools leveraging the interdisciplinary team are warranted. This work will be supplemented by interviews and live observations to build tailored educational tools for OR teams.
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Authors: Kuthethur Raviprasad , Acharya Ananya , Sengodan Satheesh Kumar , Fonseca Carmen , Nagar Nupur , Nasrin VZ Safa , Ibini Oluwakemi , Manolika Eleni-Maria , de Koning Kelly , Braunshier Stefan , Dessapt Julien , Fradet-Turcotte Amélie , Lebbink Joyce H.G. , Kanaar Roland , Poluri Krishna Mohan , Sharan Shyam K. , Cejka Petr , Chaudhuri Arnab Ray 
Published: November 2024

ABSTRACTHomologous recombination (HR) deficiency upon BRCA2 loss arises from defects in the formation of RAD51 nucleoprotein filaments. Here, we demonstrate that loss of the anti-recombinase FIGNL1 retains RAD51 loading at DNA double-stranded breaks (DSBs) in BRCA2-deficient cells, leading to genome stability, HR proficiency, and viability of BRCA2-deficient mouse embryonic stem cells. Mechanistically, we directly show that strand invasion and subsequent HR defects upon BRCA2 loss primarily arises from the unrestricted removal of RAD51 from DSB sites by FIGNL1, rather than from defective RAD51 loading. Furthermore, we identify that the MMS22L-TONSL complex interacts with FIGNL1 and is critical for HR in BRCA2/FIGNL1 double-deficient cells. These findings identify a pathway for tightly regulating RAD51 activity to promote efficient HR, offering insights into mechanisms of chemoresistance in BRCA2-deficient tumors.
Systems metabolic engineering ofCorynebacterium glutamicumfor efficient L-tryptophan production
Authors: Dong Yufei , Chen Zhen 
Published: November 2024

AbstractCorynebacterium glutamicum is a versatile industrial microorganism for producing various amino acids. However, there have been no reports of well-defined C. glutamicum strains capable of hyperproducing L-tryptophan. This study presents a comprehensive metabolic engineering approach to establish robust C. glutamicum strains for L-tryptophan biosynthesis, including: (1) identification of potential targets by enzyme-constrained genome-scale modeling; (2) enhancement of the L-tryptophan biosynthetic pathway; (3) reconfiguration of central metabolic pathways; (4) identification of metabolic bottlenecks through comparative metabolome analysis; (5) engineering of the transport system, shikimate pathway, and precursor supply; and (6) repression of competing pathways and iterative optimization of key targets. The resulting C. glutamicum strain achieved a remarkable L-tryptophan titer of 50.5 g/L in 48h with a yield of 0.17 g/g glucose in fed-batch fermentation. This study highlights the efficacy of integrating computational modeling with systems metabolic engineering for significantly enhancing the production capabilities of industrial microorganisms.
Life shocks and self-perceived risk of housing loss among low-income individuals
Authors: Byrne Thomas H. , Hahm Christian , Tamta Mohit , Montgomery Ann Elizabeth 
Published: November 2024

Purpose
This study aims to describe the self-perceived risk of housing loss among low-income individuals in the context of four potential life shocks and examines whether individuals’ social and economic resources are protective against self-perceived risk of housing loss in the context of these life shocks.

Design/methodology/approach
The authors conducted a national online survey of low-income households in the USA. The authors asked respondents to assess whether they would be at risk of housing loss if they experienced any of four potential life shocks: job loss, moderate and major medical catastrophes and damage to home from natural disaster. Logistic regression models estimated the association between self-perceived risk of housing loss in the context of these life shocks and respondents’ economic and social resources, adjusting for sociodemographic covariates.

Findings
A minority of respondents reported that they would be able to maintain their housing if they were to experience a life shock (i.e. 34%–43% depending on the specific life shock). Receipt of more generous forms of income support as well as having family or friends to live with in the event of housing loss were the most consistent economic and social resource predictors of respondents’ self-perceived ability to maintain their housing in the context of a life shock.

Originality/value
The findings suggest that comprehensive assessments of risk of housing crises should take into account how individuals view their vulnerability to housing loss if they were to experience a life shock.
The power of oversight: institutional investors as moderators of the earnings quality-information asymmetry nexus in Europe
Authors: Eliwa Yasser , Haslam Jim , Abraham Santhosh , Saleh Ahmed 
Published: November 2024

Purpose
While there is some evidence of a relationship between earnings quality and information asymmetry, there is limited evidence on the moderating role of institutional investors in this relationship. To fill this gap, this study aims to examine how institutional ownership affects the relationship between earnings quality and information asymmetry, with a focus on the impact of different investment horizons.

Design/methodology/approach
This study uses a sample of listed European firms from 2000 to 2022. Earnings quality is measured using the McNichols (2002) modification of the Dechow and Dichev (2002) model. The analysis examines the moderating effect of institutional ownership on the relationship between earnings quality and information asymmetry.

Findings
This study finds that the relationship between earnings quality and information asymmetry is more pronounced in firms with a higher percentage of institutional ownership. This study finds that the monitoring role of long-term institutional investors is more effective than that of short-term institutional investors. This study also finds that the influence of institutional investors is more significant in firms with incentives to engage in earnings management.

Practical implications
The findings provide evidence suggesting that institutional investors are an important class of investors in terms of exercising an effective monitoring role to mitigate information asymmetry and demand higher earnings quality from their investee firms. These findings are informative for many financial reporting participants, including investors, analysts, regulators and managers.

Originality/value
This study extends the existing research examining the relationship between earnings quality and information asymmetry (e.g. Affleck-Graves et al., 2002; Ascioglu et al., 2012; Bhattacharya et al., 2013; Jayaraman, 2008; Liu and Elayan, 2015) by examining the moderating effect of institutional ownership on this relationship. It further contributes to the literature by distinguishing between long- and short-term institutional investors and their respective monitoring roles. In addition, this study broadens the geographical scope of the research by using cross-country data from European firms, providing evidence that country-specific factors do not uniformly affect the relationship between earnings quality and information asymmetry.
Institutional policing work in a constellation of labels and spaces of place: video game development management insights
Authors: Gidley Devon , Palmer Mark 
Published: November 2024

Purpose
This paper aims to explore (a) the dynamics of place and space in an institutional setting and (b) institutional work done in different spaces of the same place.

Design/methodology/approach
Traditional ethnographic methods (participant-observation, interviews and artefacts) were used over the course of 12 months of fieldwork in a multi-organizational video game development space.

Findings
The paper presents two main findings. First, the authors show how the place was a dynamic rainbow constellation and manifested as different spaces over time and for different actors. The authors describe the spaces based on existing literature (accelerator, experimental, incubator or coworking space) or inductively (atrium and hybrid). Second, the authors show how institutional work changed depending on the spatial conceptions of the institutional place. In particular, the authors show dynamic rainbow constellation of fluid spaces raises different forms of institutional policing work (self, backroom, spectacle, tangential and preventative) and the conditions under which institutional policing work is subtly fluid and takes form, but also changes.

Originality/value
Significant contributions are made to understanding how actors work at forming a rainbow constellation ring of fluid labels and spaces of a place. This paper explicates and amplifies the forms of institutional policing work, providing a novel case example of that social interaction.
Quality management practices toward project performance in healthcare sector: modelling the mediating role of intellectual capital
Authors: Shah Syed Asim , Sultan Khalid , Shoukat Muhammad Haroon , Rehman Shafique Ur 
Published: November 2024

PurposeThe study examines the influence of quality management practices (QMP) on project performance (PP) and the indirect association of QMP with PP through the mediating role of intellectual capital (IC). QMP may be one of the most successful strategies to improve project performance. Drawing on the resource-based view (RBV) and institutional theory, the study examines the impact of QMP on PP through the mediating role of IC.Design/methodology/approachThe sample frame of 329 employees in different NGOs and public healthcare organizations was selected. Data were analyzed on SmartPLS 3.2.7 by applying SEM.FindingsThe outcome reveals that QMP has a significant impact on PP. The results found partial mediation of IC on the linkage between QMP and PP.Research limitations/implicationsThe key research limitation was that it examined only two antecedents (QMP and IC) of project performance based on RBV and institutional theory, which did not yield deep insights from other institutional forces that could influence the model, such as mimetic pressure, institutional pressure and business orientation.Originality/valueQMP is highly significant in the healthcare sector; however, research on the relationship between QMP, IC and PP is lacking. Thus, this research is an initial attempt to investigate these relationships empirically. We add to our understanding of RBV by investigating the role of IC in mediating the QMP-PP linkage.
Grocery retailers’ CSR: the role of claim type
Authors: Untilov Olga , Louis Didier , Charton-Vachet Florence , Lombart Cindy 
Published: November 2024

PurposeThis study examines how substantive and/or associative claims about the local origin of organic products moderate the determinants and consequences of a grocery retailer’s corporate social responsibility (CSR).Design/methodology/approachAn experiment with four different conditions – no claim, substantive claim (i.e. number of kilometres), associative claim (i.e. photograph of the producer) and a combination of substantive and associative claims – was carried out in a laboratory store in France with 249 consumers who were randomly divided into four independent samples (a between-subjects design). To analyse the data, partial least squares structural equation modelling was mobilised using XLSTAT (2022) software.FindingsThe study indicates that using claims about the local origin of organic products via in-store signage is an appropriate tool for grocery retailers. For the three types of claims considered, the ethics of the offering influences the retailer’s CSR, which has an indirect impact on consumers’ actual purchases of local organic products via two routes: trust and affective commitment and trust and preference for the retailer. However, grocery retailers should favour a combination of substantive and associative claims to create a stronger impact on purchases.Originality/valueThis research extends the use of substantive and associative claims to sustainable products.
The professional logics of accounting education in MENA countries: evidence from Egypt and KSA
Authors: Diab Ahmed 
Published: November 2024

PurposeThis study investigates the influence of the surrounding institutional context, with a particular focus on the professional perspective, on accounting education in two leading developing countries in the Middle East and North Africa (MENA) region, Egypt and the Kingdom of Saudi Arabia (KSA), by focusing on public universities’ undergraduate level in the two countries.Design/methodology/approachFollowing an interpretative approach, this study uses data collected mainly through interviews with the members of the key accounting professional and regulatory bodies, accounting professors and accounting graduates in Egypt and KSA. Theoretically, this study uses insights from the institutional theory to understand the institutional context shaping accounting education in the two examined settings.FindingsDespite sharing several cultural aspects, we noticed differences in accounting education in the two MENA countries. We explained how the dominant institutional perspective in these contexts (i.e. the professional perspective) affects accounting education, resulting in various implications for accounting graduates and the accounting profession. In Egypt, we noticed a retreatment of the professional perspective due to the dominance of an economic perspective informed by the worse economic conditions in the country, negatively affecting accounting education. In contrast, accounting education in KSA is primarily driven by the professional context aided by the availability of facilities and resources as well as the centrality of the role played by professionals and regulators in accounting education, which has directed accounting educators towards incorporating professional knowledge into accounting curricula.Practical implicationsBy highlighting the influence of the professional context on accounting education in a particular developing country, the findings of this study can guide regulators and policymakers in other developing countries concerning developing their accounting education programmes. Furthermore, professionals should allow accounting academics to contribute to developing the accounting profession and employers should support accounting students’ training and development.Originality/valueThis study contributes to the literature by examining the situation of accounting education beyond Western developed contexts, presenting an extensive theoretical explanation of the salient institutional perspectives shaping that situation.
Teacher epistemic curiosity: how principal–teacher conversation supports it
Authors: Adams Curt , Adigun Olajumoke Beulah , Fiegener Ashlyn 
Published: November 2024

PurposeThe purpose of this study was to introduce teacher epistemic curiosity for student learning into the leadership literature and to determine if school principals can support it. The inquiry was organized by the following research question: In what ways can principal–teacher conversations support teacher epistemic curiosity for student learning? The research question guided the review of literature on epistemic curiosity, eventually leading to the leadership practice of transformative leadership conversation (TLC). A hypothesized model on the relationship between TLC and epistemic curiosity for student learning was advanced from research on student and employee curiosity and self-determination theory.Design/methodology/approachThe hypothesized model was tested with a correlational research design. Teacher survey data were collected in December 2023 from a random sample of certified public school teachers from a metropolitan area in a southwestern state of the USA. Usable survey responses were received from 2,022 teachers, resulting in a 55% response rate. The hypothesized model was tested with structural equation modeling in AMOS 28 using robust maximum likelihood estimation. The latent models include measurement and structural components.FindingsResults confirm the hypothesized relationships among TLC, need-satisfaction and teacher epistemic curiosity. TLC and need-satisfaction both had strong, direct relationships with teacher epistemic curiosity for student learning. TLC explained approximately 20% of the variance in teacher curiosity and need-satisfaction explained approximately 18%. The combined model accounted for approximately 55% of the variance in teacher epistemic curiosity.Originality/valueThe study emerged from robust evidence on the essential function of curiosity for knowing, learning, performance and life well-being, as well as limited research on social processes that leaders can leverage to stimulate teachers’ motivation to understand how their students learn. Curiosity is an inner energy behind learning; it fuels an innate drive to explore, know, create, design and adapt to our surroundings. Schools and classrooms come to life when teachers and students engage in learning from a place of curiosity, making this motivational resource worthy of leadership attention.
Do stock prices affect corporate tax behavior?
Authors: Kunz Philip William 
Published: November 2024

Purpose
This study aims to examine how firm-specific information in stock prices influences corporate tax behavior.

Design/methodology/approach
This study uses ordinary least squares (OLS) regressions to examine the association between stock price informativeness and effective tax rate (ETR) volatility.

Findings
Stock price informativeness is positively associated with short-term tax avoidance as measured by ETR volatility.

Originality/value
While prior research examines the association between market activity and the level of ETRs, this study examines other various aspects of tax behavior.
The nexus between spirituality and personal financial behavior: a study of students with entrepreneurial intentions
Authors: Jangid Jatin , Bhardwaj Bhawana , Sharma Dipanker 
Published: November 2024

PurposeThe current study explores the relation between students' spiritual quotient (SQ) and personal financial planning (PFP). The students with entrepreneurial intentions were considered for the present study.Design/methodology/approachThe students from higher educational institutes with an intention to be entrepreneurs were considered for data collection. Using a well-designed, closed-ended questionnaire, primary data from college and university students was collected. Using quota sampling, a total of 189 responses were gathered, however the responses of students with entrepreneurial intentions (n = 100) were considered for analysis. To investigate the relationship between PFP and SQ, descriptive analysis, Spearman's rank correlation and forecasted trend line were employed.FindingsThe study revealed a significant positive relationship between PFP and SQ. Thus, SQ also has potential to determine individuals' investment behavior. The study suggests that students' spiritual development can determine their PFP and entrepreneurial actions.Practical implicationsThe outcome of the study can be practically used to explore the investment pattern and behavior of youth. The study would further benefit the stakeholders including issuers, developers and consultants involved in the creation and distribution of financial products. The study guides researchers to undertake further research in this domain.Originality/valueThe existing literature on personal financial behavior has lacked in establishing a relationship between spirituality and investment decisions. The present study is novel in substantiating this void. We contribute to the advancement of literature in behavioral finance. This study identifies multifaceted factors that shape investors' behaviors and preferences in finance and proposes the avenues for future research.