bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Sick and tired’: Patients reported reasons for not participating in clinical psychiatric research
Authors: Bixo Liv , Cunningham Janet L. , Ekselius Lisa , Öster Caisa , Ramklint Mia 
Published: October 2019

AbstractBackgroundMeaningful and generalizable research depends on patients' willingness to participate. Studies often fail to reach satisfactory representativeness.ObjectiveThis paper aims to investigate reasons for not participating in research among young adult patients with psychiatric illness.MethodA quantitative cross‐sectional study was performed based on questionnaires reported on by 51 psychiatric patients (14 males, 35 females and two unspecified) who had previously declined participation in an ongoing research project. Thereafter, a qualitative interview with subsequent content analysis was conducted with ten additional patients (five males, five females).ResultsThe questionnaires indicate being ‘too tired/too sick to participate’ as the most common barrier. Lack of time and fear of needles were other common barriers. Lack of trust or belief in the value of research was less inhibitive. In the interviews, disabling psychiatric symptoms were confirmed as the main reason for not participating. Several potential ways to increase participation were identified, such as simplification of procedures and information as well as providing rewards and feedback, and building relationships before asking.ConclusionThis study is unusual as it focuses on the group of young people attending psychiatry outpatient clinics we know very little about – those who do not partake in research. Our results indicate that fatigue and sickness reduce research participation and identify factors that may facilitate enrolment of this important group.
The association of memory disorders and chronic HIV disease in the antiretroviral therapy era: a systematic literature review
Authors: Ripamonti E , Clerici M 
Published: October 2019

ObjectivesDespite recent pharmacological progress, memory impairment is still frequently reported in people living with HIV. We aimed to conduct a systematic literature review investigating the presence of impairment of (sub)components of memory function in patients prescribed highly active antiretroviral therapy (ART).MethodsWe adopted a cognitive neuropsychological model of memory function as the theoretical framework, distinguishing between a short‐term working memory component and a long‐term component of memory, along with their specific (sub)components. We systematically searched for the presence of impairment of each (sub)component in the selected papers. Careful consideration was given to study design and methods and control of covariates.ResultsOnly the central executive component of working memory has been consistently reported to be impaired in HIV infection. The other two (sub)components, namely the phonological loop and the visuospatial sketchpad, were unimpaired. Discordant results have been obtained as to verbal and visual episodic memory, as some authors reported an association with HIV infection, whereas others did not. There is little evidence for semantic memory deficit in HIV infection, while there are suggestions that the neural substrate of implicit memory may be damaged by the effects of HIV infection and inflammation. Most studies in this area have been conducted in small samples and with poor control for covariates. Thus, conclusions regarding the association of memory dysfunction with HIV infection are hampered by methodological issues such as selection bias and unmeasured confounding.ConclusionsThe task remains for future research to ascertain the impact of HIV infection on memory function.
Brazilian and French sensory perception of complex cosmetic formulations: a cross‐cultural study
Authors: Calixto Lívia Salomão , Maia Campos Patrícia M.B.G. , Picard Céline , Savary Géraldine 
Published: October 2019

AbstractObjectiveBrazil and France are two major beauty markets worldwide. Despite this, there is not much cross‐information on sensory analysis of cosmetic products between both population of these countries. The objective of this study was to compare the sensory perception of cosmetic formulations between Brazilian and French assessors and establish cross‐culturally preferences.MethodsFor this, a total panel of 100 consumers of cosmetics evaluated four different products. The same protocol for the sensory analysis was followed in both countries.ResultsThe panellists were able to perceive differences in the products and the method proved to be repeatable in both countries. The presence of UV filters in the formulation was noticed and displeased both populations. Brazilians, although dissatisfied with the sensory aspect of the sunscreen, are willing to use it for its UV protection.ConclusionThis work delivers important information on the sensory perception of cosmetics by people from different countries and brings important knowledge to develop products with textural properties that will be appreciated worldwide.
SELLING IN ADVANCE TO LOSS AVERSE CONSUMERS
Authors: Karle Heiko , Möller Marc 
Published: October 2019

AbstractThis article examines the influence of information on market performance in an advance purchase setting. Information reduces the risk that an advance purchase results in a mismatch between consumer preferences and product characteristics. However, information may also raise the number of advance purchases by increasing firms' incentive to offer advance purchase discounts. Accounting for consumers' aversion toward losses/risks turns out to be crucial as it changes our assessment of policies aiming to improve consumers' information: Under monopoly, information can be detrimental both for efficiency and consumer surplus, whereas under competition, information is doubly beneficial because it mitigates intertemporal business stealing.
Fabrication of fused silica‐based cores by the gel‐casting method: Modeling by response surface methodology
Authors: Poorvahab Tayyebeh , Kazemi Arqavan , Haghshenas Davoud 
Published: October 2019

AbstractIn this study, fused silica‐based cores fabrication via gel‐casting procedure was modeled via the response surface methodology (RSM). Zircon content, alumina content, and sintering time were selected as variables and the influences of these parameters on the characteristic of the prepared samples were investigated. Two series of experiments were organized; (i) evaluation and modeling of the sintered samples and (ii) evaluation and modeling of the samples which passed pouring‐simulation treatment. Mechanical strength, porosity content, and leachability were selected as the response parameters and the obtained numerical data were analyzed using the Minitab software. Based on the RSM principles, the main effects plots and contour plots were recorded and the system was studied by means of a statistical model. However, both series of samples were evaluated and mathematical regression equations were gained from the RSM technique for modeling the response parameters; MOR, porosity, and leachability. Results showed that in the sintered samples, the most effective parameters on the MOR, porosity, and leachability values were Al2O3 content, zircon content & sintering time, and zircon content, respectively. It is interesting that in the pouring‐simulated samples, the most effective variable on the response parameters was Al2O3 content.
The role of bioidentical hormone replacement therapy in anti‐aging medicine: a review of the literature
Authors: Rosenthal Amanda , Jacoby Ted , Israilevich Rachel , Moy Ronald 
Published: October 2019

AbstractThe changes in skin and overall appearance that occur with increasing age can be partly attributed to declining hormone levels. While hormonal deficiencies are most commonly associated with postmenopausal females, males are also subject to age‐related testosterone decline and may benefit from replacement of deficient hormones. However, great disparities exist between the recommendations of scientific societies and actual use of hormone supplements in aging patients. The purpose of this literature review is to discuss the role of hormones in the aging process of the skin, explain the safety profile of hormone replacement therapy, specifically discussing the superiority of bioidentical hormones, and highlight the benefits of hormone replacement in anti‐aging of the skin. In summary, this literature review suggests that hormone replacement with bioidentical hormones is a safe and effective way to prevent skin aging.
Sustainability with endogenous discounting
Authors: Hartwick John M. , Van Long Ngo 
Published: October 2019

AbstractWe construct a dynamic competitive model with a stock of human‐made capital and several stocks of natural resources and ask under what conditions consumption will be constant if infinitesimal households with heterogeneous preferences and endowments discount their utility at an endogenous rate that depends on some macroeconomic variables. We show that for consumption to be constant, this function must be the marginal product of capital function. We demonstrate that Hartwick's rule holds in a modified form that takes account of natural growth of resource stocks.
Acute kidney injury in acute Q fever
Authors: Stewart Adam G. , Broom Jennifer , Sowden David , Hollett Peter 
Published: October 2019

Abstract
Coxiella burnetii infection is not known to involve directly the kidneys. Kidney injury associated with Q fever usually manifests in the setting of chronic infection or endocarditis with development of immune complex deposition. Acute kidney injury (AKI) in the context of acute Q fever infection may be more pathologically heterogeneous. We describe two cases of severe AKI secondary to acute Q fever infection, each with marked differences in pathological characteristics, and clinical course.
Microbiota characterization of sheep milk and its association with somatic cell count using 16s rRNA gene sequencing
Authors: Esteban‐Blanco Cristina , Gutiérrez‐Gil Beatriz , Puente‐Sánchez Fernando , Marina Héctor , Tamames Javier , Acedo Alberto , Arranz Juan José 
Published: October 2019

AbstractThis work aimed to use 16S ribosomal RNA sequencing with the Illumina MiSeq platform to describe the milk microbiota from 50 healthy Assaf ewes. The global observed microbial community for clinically healthy milk samples analysed was complex and showed a vast diversity. The core microbiota of the sheep milk includes five genera: Staphylococcus, Lactobacillus, Corynebacterium, Streptococcus and Escherichia/Shigella. Although there are some differences, some of these genera are common with the microbiota core pattern of milk from other species, especially with dairy cows. The microbial composition of the studied samples, based on the definition of amplicon sequence variants, was analysed through a correlation network. A preliminary analysis by grouping the milk samples based on their somatic cell count (SCC), which is considered an indicator of subclinical mastitis (SM), showed certain differences for the core of the samples identified as SM. The differences in the microbiota diversity pattern among samples might also suggest that subclinical mastitis would be associated with the significant increase in some genera that are inhabitants of the mammary gland and a remarkable concomitant reduction in the microbial diversity. Additionally, we have also presented here a preliminary analysis to assess the impact of the sheep milk microbiome on SCC, as an indicator of subclinical mastitis. The results here reported provide a first characterization of the sheep milk microbiota and settle the basis for future studies in this field.
The Effect of Taxes on the Location of Property‐Casualty Insurance Firms
Authors: Grace Martin F. , Sjoquist David L. 
Published: October 2019

AbstractStates levy insurance premium taxes, which are essentially gross receipt taxes on premiums. An unusual characteristic of insurance premium taxes is that in each state in which an insurance company writes premiums, the firm pays the higher of the tax rate in the state in which the company is domiciled and the state in which the policy is written. Thus, the choice of location has a significant effect on the firm's tax liability. Using firm‐level data for the property‐casualty (P‐C) insurance industry, we calculate the firm‐specific tax rate for each P‐C firm for every possible state of domicile. We estimate conditional logistic models to analyze the effect of insurance premium taxes on the choice of the state of domicile of existing and relocated firms. We find robust evidence of a small, negative, and statistically significant effect of these taxes on the choice of the state of domicile.
Rurality and Risk of Perinatal Depression Among Women in the United States
Authors: Nidey Nichole , Tabb Karen M. , Carter Knute D. , Bao Wei , Strathearn Lane , Rohlman Diane S. , Wehby George , Ryckman Kelli 
Published: October 2019

AbstractObjectiveRural populations may experience more frequent and intense risk factors for perinatal depression than their urban counterparts. However, research has yet to examine rural versus urban differences in a population‐based study in the United States. Therefore, this study examined differences in risk of perinatal depression between women living in rural versus urban areas in the United States.MethodUsing 2016 data from the Pregnancy Risk Assessment Monitoring System, we examined the association between rural‐urban status and the risk of depression during the perinatal time period. The total analytical sample included 17,229 women from 14 states. The association between rural‐urban status and risk of perinatal depression was estimated using logistic regression, adjusting for race/ethnicity, maternal age, and state of residence. A second model adjusted for maternal education, health insurance status, and Women, Infants, and Children Special Supplemental Nutrition Program (WIC).ResultsOdds of perinatal depression risk were higher by 21% among rural versus urban women (OR = 1.21, 95% CI: 1.05‐1.41) adjusted for race, ethnicity, and maternal age. This risk difference became smaller and not significant when adding maternal education, health insurance coverage, and WIC participation.ConclusionFindings suggest a rural‐urban inequality in perinatal depression risk. Reducing this inequality may require improving socioeconomic conditions and reducing associated risk factors among rural women.
Suppression of abscisic acid biosynthesis at the early infection stage of Verticillium longisporum in oilseed rape (Brassica napus)
Authors: Behrens Falk H. , Schenke Dirk , Hossain Roxana , Ye Wanzhi , Schemmel Markus , Bergmann Thomas , Häder Claudia , Zhao Yan , Ladewig Lena , Zhu Wenxuan , Cai Daguang 
Published: October 2019

SummaryVerticillium longisporum infects oilseed rape (Brassica napus) and Arabidopsis thaliana. To investigate the early response of oilseed rape to the fungal infection, we determined transcriptomic changes in oilseed rape roots at 6 days post‐inoculation (dpi) by RNA‐Seq analysis, in which non‐infected roots served as a control. Strikingly, a subset of genes involved in abscisic acid (ABA) biosynthesis was found to be down‐regulated and the ABA level was accordingly attenuated in 6 dpi oilseed rape as compared with the control. Gene expression analysis revealed that this was mainly attributed to the suppression of BnNCED3‐mediated ABA biosynthesis, involving, for example, BnWRKY57. However, this down‐regulation of ABA biosynthesis could not be observed in infected Arabidopsis roots. Arabidopsis ABA‐ defective mutants nced3 and aao3 displayed pronounced tolerance to the fungal infection with delayed and impeded symptom development, even though fungal colonization was not affected in both mutants. These data suggest that ABA appears to be required for full susceptibility of Arabidopsis to the fungal infection. Furthermore, we found that in both 6 dpi oilseed rape and the Arabidopsis nced3 mutant, the salicylic acid (SA) signalling pathway was induced while the jasmonic acid (JA)/ethylene (ET) signalling pathway was concomitantly mitigated. Following these data, we conclude that in oilseed rape the V. longisporum infection triggers a host‐specific suppression of the NCED3‐mediated ABA biosynthesis, consequently increasing plant tolerance to the fungal infection. We believe that this might be part of the virulence strategy of V. longisporum to initiate/establish a long‐lasting compatible interaction with oilseed rape (coexistence), which appears to be different from the infection process in Arabidopsis.
Gene expression analysis of Cyanophora paradoxa reveals conserved abiotic stress responses between basal algae and flowering plants
Authors: Ferrari Camilla , Mutwil Marek 
Published: October 2019

Summary

The glaucophyte Cyanophora paradoxa represents the most basal member of the kingdom Archaeplastida, but the function and expression of most of its genes are unknown. This information is needed to uncover how functional gene modules, that is groups of genes performing a given function, evolved in the plant kingdom.

We have generated a gene expression atlas capturing responses of Cyanophora to various abiotic stresses. The data were included in the CoNekT‐Plants database, enabling comparative transcriptomic analyses across two algae and six land plants.

We demonstrate how the database can be used to study gene expression, co‐expression networks and gene function in Cyanophora, and how conserved transcriptional programs can be identified. We identified gene modules involved in phycobilisome biosynthesis, response to high light and cell division. While we observed no correlation between the number of differentially expressed genes and the impact on growth of Cyanophora, we found that the response to stress involves a conserved, kingdom‐wide transcriptional reprogramming, which is activated upon most stresses in algae and land plants.

The Cyanophora stress gene expression atlas and the tools found in the https://conekt.plant.tools/ database thus provide a useful resource to reveal functionally related genes and stress responses in the plant kingdom.
Inner ear morphology of diadectomorphs and seymouriamorphs (Tetrapoda) uncovered by high‐resolution x‐ray microcomputed tomography, and the origin of the amniote crown group
Authors: Klembara Jozef , Hain Miroslav , Ruta Marcello , Berman David S , Pierce Stephanie E. , Henrici Amy C. 
Published: October 2019

AbstractThe origin of amniotes was a key event in vertebrate evolution, enabling tetrapods to break their ties with water and invade terrestrial environments. Two pivotal clades of early tetrapods, the diadectomorphs and the seymouriamorphs, have played an unsurpassed role in debates about the ancestry of amniotes for over a century, but their skeletal morphology has provided conflicting evidence for their affinities. Using high‐resolution X‐ray microcomputed tomography, we reveal the three‐dimensional architecture of the well preserved endosseous labyrinth of the inner ear in representative species belonging to both groups. Data from the inner ear are coded in a new cladistic matrix of stem and primitive crown amniotes. Both maximum parsimony and Bayesian inference analyses retrieve seymouriamorphs as derived non‐crown amniotes and diadectomorphs as sister group to synapsids. If confirmed, this sister group relationship invites re‐examination of character polarity near the roots of the crown amniote radiation. Major changes in the endosseous labyrinth and adjacent braincase regions are mapped across the transition from non‐amniote to amniote tetrapods and include: a ventral shift of the cochlear recess relative to the vestibule and the semicircular canals; cochlear recess (primitively housed exclusively within the opisthotic) accommodated within both the prootic and the opisthotic; development of a distinct fossa subarcuata. The inner ear of seymouriamorphs foreshadows conditions of more derived groups, whereas that of diadectomorphs shows a mosaic of plesiomorphic and apomorphic traits, some of which are unambiguously amniote‐like, including a distinct and pyramid‐like cochlear recess.
Genetic patterns and changes in availability of suitable habitat support a colonisation history of a North American perennial plant
Authors: De la Rosa‐Conroy L. , Gasca‐Pineda J. , Bello‐Bedoy R. , Eguiarte L. E. , Arteaga M. C. 
Published: October 2019

Abstract

Climatic fluctuations during the Pleistocene influenced the geographical distribution of plant species across the southern region of California. Following an integrative approach, we combined genetic data analysis with Environmental Niche Models (ENMs) to assess the historical range expansion of Yucca schidigera, a long‐lived desert perennial native of the Baja California Peninsula.

We genotyped 240 individuals with seven nuclear microsatellite to investigate genetic diversity distribution across 13 populations. Indeed, we used Environmental Niche Models to examine the changes on the distribution of suitable climatic conditions for this species during the LIG (~120 ka), LGM (~22 ka) and Mid Holocene (~6 ka).

We detected high genetic diversity across Y. schidigera populations (AR = 9.94 ± 0.38 SE; Hexp = 0.791 ± 0.011 SE) with genetic variation decreasing significantly with latitude (allelic richness: R 2 = 0.38, P = 0.023; expected heterocigosity: R2 = 0.32, P = 0.042). We observed low, but significant genetic differentiation (FST = 0.0678; P < 0.001) which was consistent with the parapatric distribution of the three genetic groupings detected by the Bayesian clustering algorithm. The ENMs suggest that suitable habitat for this species increased since the LGM.

Our results support a range expansion of Y. schidigera across northwestern Baja California during the late Quaternary. Genetic data suggest that colonization of the current distribution followed a southward directionality as suitable climatic conditions became widely available in this region. High genetic variation across our sample suggests large historic effective population sizes for this section of the geographical range.