bluuebunny/crossref_metadata_2025_split huggingface dataset:
Missões em Diálogo
Authors: Sá Lucia Helena Alves 
Published: August 2019

De modo inovador e crítico, Antonio Candido estudou a Literatura Brasileira, sustentando a nossa identificação cultural no lastro social-coletivo e revertendo a imagem do Brasil no contexto internacional. Ademais, ao aludir à expressão Missão Portuguesa, deu novo sentido à importância de Portugal para a formação da intelectualidade brasileira que encontra apoio, entre outros, no pensamento e obra do humanista Agostinho da Silva.
Educação Estatística e desenvolvimento do sentido de número: uma inter-relação possível
Authors: Campos Sandra Gonçalves Vilas Bôas , Wodewotzki Maria Lúcia Lorenzetti 
Published: August 2019

Apresentamos parte de nossa pesquisa de Doutorado, desenvolvida junto ao Programa de Pós-Graduação em Educação Matemática/UNESP- Campus Rio Claro. Procuramos compreender de que forma a Educação Estatística pode contribuir para que as crianças do 1º ano do ciclo de alfabetização desenvolvam o Sentido de Número. Realizamos uma investigação de cunho qualitativo na modalidade estudo de caso e buscamos referencial teórico na Educação Estatística, nos estudos sobre Sentido de Número e Investigação Matemática. A coleta de dados foi realizada, por meio de um conjunto de tarefas aos quais denominamos Contextos de investigação. Realizamos observação participante pois coube à pesquisadora a aplicação das tarefas. Em nossa análise, inferimos que as crianças adquiriram habilidades para usar números e métodos quantitativos, se envolveram com conceitos de números, operações com números, e aplicações de números e operações. Na inter-relação número segundo o contexto da estatística e número segundo o contexto da matemática as tarefas ficaram impregnadas de Sentido de número. Constatamos que as tarefas do contexto da Estatística que permitam a criança coletar, tabular, analisar dados e comunicar suas ideias favorecem a exploração de números e suas relações e são elementos essenciais para o desenvolvimento do Sentido de Número das crianças.
A influência dos aspectos emocionais nos disturbios de aprendizagem
Authors: Bertti Carolina Teixeira 
Published: August 2019

É de extrema importância ressaltar a relevância dos aspectos emocionais no que se refere aos processos de aprendizagem, dessa maneira, o objetivo desta pesquisa de revisão bibliográfica é demonstrar os processos de aprendizagem sob a ótica dos principais teóricos da psicologia com o intuito de apontar as principais características emocionais encontradas em crianças que apresentam dificuldades de aprendizagem, a fim de criar uma relação entre os conflitos vivenciados e as dificuldades apresentadas, destacando a importância dos aspectos emocionais e psicológicos não somente para a aprendizagem, mas, de forma geral, para a condução saudável da vivência humana, mostrando que a atuação do psicólogo escolar é de estrema importância para um desenvolvimento educacional mais estruturado
Mudanças nas concepções de atitudes relacionadas com Ciência, Tecnologia e Sociedade (CTS), identificadas a partir de uma atividade de ensino com emprego de Sequência Didática (SD) com enfoque na Natureza da Ciência e da Tecnologia (NDC&T)
Authors: Sepini Ricardo Pereira , Maciel Maria Delourdes 
Published: August 2019

Nesta tese investigou-se as possibilidades de mudanças de concepções atitudinais sobre Ciência, Tecnologia e Sociedade (CTS)/Natureza da Ciência e Tecnologia (NdC&T). Procuramos responder a seguinte questão: que mudanças de concepções atitudinais em relação aos temas CTS/NdC&T podem ser provocadas nos estudantes concluintes do Ensino Médio e da Graduação em Ciências Biológicas, a partir de uma intervenção pedagógica com emprego de uma sequência didática (SD)? Esta pesquisa justifica-se pela importância do tema e pela necessidade de apontar caminhos para minimizar as carências já diagnosticadas em outras pesquisas e contribuir para o planejamento e a realização de atividades de ensino e aprendizagem relacionados com o enfoque CTS/NdC&T. O objetivo geral foi contribuir para melhorar a compreensão e a qualidade do ensino e da aprendizagem sobre NdC&T de estudantes de escola básica e da graduação por meio de um instrumento de intervenção didática. Optamos pela pesquisa intervenção experimental por conjugar métodos qualitativos e quantitativos. Como modelo estatístico utilizou-se o teste de Wilcoxon. A comparação entre os resultados da Escola Básica com os da Graduação revelou que os estudantes apresentam concepções atitudinais muito próximas; que a SD quando desenvolvida e aplicada de forma intencional e explícita, é um potencial instrumento de melhoria da compreensão acerca de questões relacionadas com NdC&T/CTS. Concluímos e defendemos nesta tese, que mudanças de concepções atitudinais CTS/NdC&T podem ser intencionalmente provocadas no espaço da sala de aula, desde que no processo de ensino e aprendizagem sejam empregados instrumentos didáticos inovadores e adequados à formação pretendida, ou seja, instrumentos pautados no enfoque CTS/NdC&T, no desenvolvimento do pensamento crítico e no compromisso com a formação para a cidadania.
TELAAH METODE DIAGNOSIS CEPAT DAN PENGOBATAN INFEKSI <em>Salmonella typhi</em>
Authors: Hardianto Dudi 
Published: August 2019

Review on Rapid Diagnosis Method and Treatment of Salmonella typhi Infection ABSTRACTSalmonella is a genus of gram-negative bacilli which are pathogenic for human. Recently over 2,500 serotypes of Salmonella have been reported. Of these, the most common serotype causing typhoid fever which is acute infectious disease in small intestine due to S. typhi entering the body through contaminated food or drink. S. typhi infection remains a major public health concern worldwide because of the subsequent economic burden for the cost of surveillance, prevention, and treatment. In Indonesia, typhoid fever is an endemic disease that threatens public health and becomes a complex problem because it increases career cases and drug resistance, so its diagnosis is needed. Although there is already a diagnosis method of typhoid fever conventionally, a fast, easy and reliable diagnosis method is needed to diagnose typhoid fever by medical personnel in endemic countries. Typhoid fever is treated by antibiotics and prevention efforts are carried out through vaccination.Keywords: antibiotics, pathogen, rapid detection, Salmonella typhi, typhoid fever ABSTRAKSalmonella adalah bakteri basil gram negatif yang bersifat patogen terhadap manusia dan saat ini telah dilaporkan lebih dari 2.500 serotipe. Salah satu serotype Salmonella diketahui menyebabkan penyakit demam tifoid yaitu infeksi akut pada usus halus akibat S. typhi yang masuk ke dalam tubuh melalui makanan dan minuman yang tercemar. Infeksi S. typhi menjadi masalah utama dalam kesehatan masyarakat di seluruh dunia karena bebani ekonomi yang ditimbulkannya untuk biaya pengawasan, pencegahan, dan pengobatan. Di Indonesia, demam tifoid merupakan penyakit endemis yang mengancam kesehatan masyarakat dan menjadi masalah kompleks karena demam tifoid meningkatkan kasus-kasus karier dan resistensi obat sehingga diperlukan diagnosisnya. Meskipun sudah ada diagnosis demam tifoid secara konvensional, tetapi diperlukan metode diagnosis yang cepat, mudah dan andal untuk mendeteksi demam tifoid oleh tenaga medis yang bekerja di negara-negara endemik. Demam tifoid diobati dengan pemberian antibiotika dan dilakukan upaya pencegahan melalui vaksinasi.Kata Kunci: antibiotika, demam tifoid, deteksi cepat, patogen, Salmonella typhi
PRODUKSI LIPASE DARI ISOLAT KAPANG HASIL MUTASI UNTUK TRANSESTERIFIKASI
Authors: Nabilasani Galih Cendana , Siswodarsono Trismilah , Suhendar Dadang , Mubarik Nisa Rachmania 
Published: August 2019

Lipase Production by Mutant Fungal Isolates for Transesterification ABSTRACTLipase is used amongst others in biodiesel production, namely in the transesterification reaction. Kernel B (KB) was a fungus isolated from the waste of palm kernel and seed. The fungus produced lipase that catalysed the transesterification reaction with a lower activity compared to that of AK Amano commercial lipase. The purpose of this study was to obtain mutant fungi with higher transesterification activities than the wild type (KB). The mutation process was carried out using ultraviolet (UV) light, ethyl methane sulfonate (EMS), and N-methyl-N’-nitro-N-nitrosoguanidine (NMNG) on KB fungus. The mutations using UV light produced 11 isolates, of which isolate m4.1KB1 produced a higher transesterification activity (0.172 U·mg-1) compared to the wild type. Mutant m5.7KB, which was generated from mutant m4.1KB1 treated using EMS, had its transesterification activity decreased to only 0.051 U·mg-1. Mutant m6.0,3KB2, which was resulted through NMNG treatment, experienced an increase in transesterification activity which was 91.2% higher than that of KB.Keywords: ethyl methane sulfonate, lipase, mutant fungi, N-methyl-N’-nitro-N-nitrosoguanidine, ultraviolet ABSTRAKLipase dimanfaatkan salah satunya dalam produksi biodiesel, yaitu dalam reaksi transesterifikasi. Kernel B (KB) merupakan kapang yang diisolasi dari limbah inti dan biji kelapa sawit, yang menghasilkan lipase sebagai katalis dalam reaksi transesterifikasi. Namun aktivitas transesterifikasi yang dihasilkan oleh lipase dari KB lebih rendah dibandingkan dengan lipase komersial AK Amano. Tujuan penelitian ini adalah mendapatkan mutan kapang dengan aktivitas transesterifikasi yang lebih tinggi dibandingkan tipe liarnya (KB). Proses mutasi dilakukan dengan menggunakan sinar ultraviolet (UV), ethyl methane sulfonate (EMS), dan N-methyl-N’-nitro-N-nitrosoguanidine (NMNG) terhadap kapang KB. Mutasi KB dengan menggunakan sinar UV menghasilkan 11 isolat, dimana isolat dengan kode m4.1KB1 menghasilkan aktivitas transesterifikasi yang lebih tinggi dibandingkan tipe liar, yaitu 0,172 U·mg-1. Mutan m5.7KB, yang dihasilkan dari mutan m4.1KB1 dengan perlakuan EMS, mengalami penurunan aktivitas transesterifikasi hingga hanya sebesar 0,051 U·mg-1. Mutan m6.0,3KB2 hasil perlakuan NMNG mengalami peningkatan aktivitas transesterifikasi sebesar 91,2% lebih tinggi dari KB.Kata Kunci: ethyl methane sulfonate, kapang mutan, lipase, N-methyl-N’-nitro-N-nitrosoguanidine, ultraviolet
EKSTRAK KAYU TEGERAN (<em>Cudrania javanensis</em> Trécul) SEBAGAI ANTI JAMUR <em>Peniophora</em> sp.
Authors: Darsih Cici , Ilyas Muhammad , Rosyida Vita Taufika , Pratiwi Diah , Indrianingsih A. Wheni , Hernawan . , Apriyana Wuri 
Published: August 2019

Antifungal Activity of Tegeran Wood (Cudrania javanensis Trécul) Extracts against Fungus Peniophora sp. ABSTRACTThe fungus Peniophora sp. can degrade natural dyes, causing discoloration on batik cloth. This study was aimed to evaluate the antifungal activity of tegeran wood (Cudrania javanensis) extracts against Peniophora sp. isolated from the aqueous extract of mahogany (Swietenia mahagoni) bark. Aqueous and methanol extraction procedures gave tegeran wood extracts whose concentrations were then varied into 100, 250 and 500 ppm. Phytochemical analysis of the extracts were carried out, and the results showed that the average values of the total polysaccharides and terpenoids of both aqueous and methanol extracts did not differ significantly (p<0.05), whereas those of polyphenols did (p<0.05). The total polyphenols of the methanol extract (484.723 mg GAE/g) was higher than that of the aqueous extract (389.903 mg GAE/g). Results showed that the methanol extract of tegeran wood showed higher antifungal activity against Peniophora sp. than the aqueous extract, and was also higher than ketoconazole control (100 ppm). The minimum inhibitory concentration of the methanol extract against Peniophora sp. growth was of 500 ppm with the antifungal activity value (AFA) of 76.30%.Keywords: antifungal activity, Cudrania javanensis, Peniophora sp., Swietenia mahagoni, wood extract ABSTRAKJamur Peniophora sp. dapat mendegradasi zat warna alam sehingga warna yang dihasilkan pada kain batik lebih pudar. Penelitian ini dilakukan untuk mempelajari aktivitas anti jamur dari ekstrak kayu tegeran (Cudrania javanensis) terhadap Peniophora sp. yang diisolasi dari ekstrak air kulit mahoni (Swietenia mahagoni). Ekstraksi menggunakan metanol dan air, menghasilkan ekstrak kayu tegeran, yang kemudian konsentrasinya divariasi menjadi 100, 250 dan 500 ppm. Analisis fitokimia ekstrak kayu tegeran dilakukan, dan hasilnya menunjukkan bahwa nilai rata-rata total polisakarida dan terpenoid ekstrak metanol dan air kayu tegeran tidak berbeda nyata (p<0,05). Sedangkan total polifenol kedua ekstrak berbeda nyata (p<0,05). Total polifenol ekstrak metanol kayu tegeran (484,723 mg GAE/g) lebih besar dibandingkan dengan ekstrak air (389,903 mg GAE/g). Hasil menunjukkan bahwa aktivitas anti jamur ekstrak metanol lebih baik dibandingkan dengan ekstrak air kayu tegeran, dan juga lebih tinggi dibandingkan dengan kontrol ketoconazole (100 ppm). Konsentrasi minimum ekstrak metanol kayu tegeran yang dapat menghambat pertumbuhan jamur Peniophora sp. adalah 500 ppm dengan nilai penghambatan (AFA) sebesar 76,30%.Kata Kunci: aktivitas anti jamur, Cudrania javanensis, ekstrak kayu, Peniophora sp., Swietenia mahagoni
PENGARUH VARIASI KONSENTRASI METANOL DAN LAMA INDUKSI TERHADAP EKSPRESI PROINSULIN OLEH <em>Pichia pastoris</em> SECARA INTRASELULER
Authors: Martius Efrida , Triyadi Andree , Sofia Dewi Yustika , Mahsunah Anis Herliyati 
Published: August 2019

The Effects of Variation in Methanol Concentration and Induction Time on Intracellular Proinsulin Expression by Pichia pastoris ABSTRACTDiabetes is a metabolic disorder characterized by hyperglycemia. There were 215 million diabetic patients in 2014 and the number is expected to rise in 2040. Generally, insulin is used to treat diabetic patients. Insulin production by recombinant technology has been done, though still inefficient, by using E. coli and S. cerevisiae expression system. Another alternative expression system is methylotrophic yeast Pichia pastoris. In this research, proinsulin has been expressed by P. pastoris intracellularly. P. pastoris strains used in this research were X33, GS115, and KM71H. All recombinant strains were MutS. Best cultivation media was BMGY. Proinsulin expression was observed at 25°C. Pichia pastoris strain that expressed proinsulin best was GS115-PI. It was supported by PCR in which the strain GS115-PI gave 504 bp-sized bands. Based on proinsulin formation time, the final methanol concentration of 0.5% in 72 hours was found to be the best treatment.Keywords: BMGY, methanol, phenotype, Pichia pastoris, proinsulin ABSTRAKDiabetes melitus merupakan kelainan yang ditandai dengan hiperglikemia. Penderita diabetes pada tahun 2014 di dunia mencapai 215 juta dan diperkirakan akan meningkat pada tahun 2040. Umumnya penderita diabetes diberi pengobatan insulin sehingga menunjukkan akan ada peningkatan kebutuhan insulin. Produksi insulin dengan teknologi DNA rekombinan telah dilakukan dengan menggunakan sistem ekspresi E. coli dan S. cerevisiae namun masih belum efisien. Sistem alternatif lain adalah ragi metilotropik Pichia pastoris. Dalam penelitian ini dilakukan ekspresi proinsulin dari P. pastoris secara intraseluler. Galur P. pastoris yang digunakan dalam penelitian ini adalah X33, GS115, dan KM71H. Semua galur rekombinan adalah MutS. Media tumbuh terbaik adalah BMGY. Ekspresi proinsulin terlihat pada suhu 25°C. Hasil PCR menunjukkan bahwa galur GS115-PI yang dapat menghasilkan pita amplikon berukuran 504 bp. Hasil PCR ini dibuktikan oleh hasil seleksi galur yang menunjukkan bahwa galur GS115-PI dapat mengekspresi proinsulin dibandingkan galur lainnya. Berdasarkan kecepatan pembentukan pita protein proinsulin, variasi konsentrasi akhir metanol 0,5% dengan lama induksi 72 jam merupakan perlakuan terbaik.Kata Kunci: BMGY, fenotipe, metanol, Pichia pastoris, proinsulin
SKRINING DAN IDENTIFIKASI MIKROBA LIGNINOLITIK PADA PENGOMPOSAN ALAMI TANDAN KOSONG KELAPA SAWIT
Authors: Rupaedah Bedah , Purwoko Devit , Safarrida Anna , Tajuddin Teuku , Wahid Abdul , Sugianto Mahmud , Sudjai Imam , Suyono Agus 
Published: August 2019

Screening and Identification of Ligninolytic Microbes in the Natural Decomposition of Oil Palm Empty Fruit Bunch ABSTRACTOPEFB (oil palm empty fruit bunch)could potentially be utilized as organic fertilizer or animal feed through composting. Information on microorganisms that play important roles in the natural decomposition of OPEFB is to date not much known yet. This research was aimed to obtain and, subsequently, to molecularly identify lignin-degrading microbial isolates responsible for naturally decomposing OPEFB in the Oil Plant Plantation and Palm Oil Refinery Plant, PTPN VIII Cikasungka, Bogor. Screening for active lignin-degrading isolates was carried out on 17 naturally decomposing OPEFB samples. A total of 19 isolates of fungi and 80 isolates of bacteria were obtained. Ligninolytic activity was measured by Sundman and Nase testing methods. Ligninolytic activity was found on 13 fungal isolates and 15 bacterial isolates. The active isolates were subsequently identified molecularly based on ITS sequence in the ribosome DNA area for fungi and in 16S rRNA genes for bacteria. The results showed that the lignin-degrading microorganisms obtained consisted of 5 bacterial isolates from the genus Bacillus and 3 fungal isolates from the genus Rhizopus and Aspergillus. Keywords: composting, lignin, microbes, OPEFB, 16S rRNA ABSTRAKTKKS (tandan kosong kelapa sawit) berpotensi dimanfaatkan sebagai pupuk organik atau pakan ternak dengan cara pengomposan. Informasi mikroba yang berperan dalam pengomposan alami TKKS hingga saat ini belum banyak diketahui. Penelitian ini bertujuan mendapatkan isolat mikroba pendegradasi lignin dalam pengomposan alami TKKS asal Perkebunan dan Pabrik Pemerasan Kelapa Sawit, PTPN VIII Cikasungka, Bogor, serta mengidentifikasi mikroba tersebut secara molekuler. Skrining mikroba aktif pendegradasi lignin dilakukan terhadap 17 sampel TKKS yang sudah lapuk secara alami. Sebanyak 19 isolat jamur dan 80 isolat bakteri telah dihasilkan. Aktivitas ligninolitik diukur dengan metode pengujian Sundman dan Nase. Isolat jamur yang memiliki aktivitas ligninolitik sebanyak 13 isolat, sedangkan bakteri sebanyak 15 isolat. Isolat-isolat aktif tersebut selanjutnya diidentifikasi secara molekuler berdasarkan pada sekuen ITS di daerah DNA ribosom untuk jamur dan menggunakan gen 16S rRNA untuk bakteri. Hasil menunjukkan bahwa 5 isolat bakteri yang memiliki kemampuan mendegradasi lignin berasal dari genus Bacillus, sedangkan 3 isolat jamur pendegradasi lignin berasal dari genus Rhizopus dan Aspergillus Kata Kunci: lignin, mikroba, pengomposan, TKKS, 16S rRNA
Sociodemographic, Socioeconomic and Clinical Risk Factors for Chronic Otitis Media in Childreen
Authors: KURT Ercan , ÇELENK Fatih , GÖNÜLDAŞ Burhanetin , TÜMÜKLÜ Koray 
Published: August 2019

Aim:The
aim of present study is to identify COM-related clinic, sociodemographic and
socioeconomic risk factors.Method:
103 children diagnosed for COM and treated in Department of
Otorhinolaryngology, Faculty of Medicine, Gaziantep University during 2005-2015
and 116 healthy children were included in this study. The questionnaire about
risk factors of COM were filled by interviewing verbatim with mothers and/or
fathers of all children.

Result:
Patient and control groups were composed of 53 boys (51.5%) and 50 girls
(48.5%), and 48 boys (41.4%) and 68 girls (58.6%), respectively. The mean age
of patients was 13.1 years (range, 2-16), and the mean age of the control group
was 12.05 years (range, 6-16). Multiple logistic regression models and
univariate analysis were used to determine association between risk factors and
COM. Maternal smoking during pregnancy (p=0.014), otitis media history in the
first year of life (p=0.001), recurrent otitis media history (p=0.001), upper
respiratory tract infection history in the first year of life (p=0.001), ventilation tube insertion history (p=0.001),
tonsillectomy and/or adenoidectomy history (p=0.001), otitis media history in
family members (p=0.008) and lack of health insurance (p=0.001) were found to
be significantly associated with COM. In multivariate analysis, otitis media
history in the first year of life (OR=8,00, %95 CI=
[3,34-19,17], p=0.001), father’s otitis media history (OR=8.43, %95
CI= [1,47-48,42], p=0.017) and lack of health insurance (OR=3,09 %95
CI=[1,35-7,11], p=0.008) were significantly associated with COM.

Conclusion: Chronic
otitis media (COM) is a long-term inflammation of middle ear that leads to
irreversible changes in eardrum. COM is a common disease in children, and if
not treated, it may cause severe complications and sequelae. Thus, if risk
factors causing COM are elucidated, the potential complications might be
prevented and prophylactic strategies can be developed. This study indicated
that history of otitis media in the first year of life, having a father with
history of otitis media and lack of health insurance are risk factors for COM.
ТРИКОТАЖ ДЛЯ ЗАСТОСУВАННЯ У ВИРОБАХ СПЕЦІАЛЬНОГО ФУНКЦІОНАЛЬНОГО ПРИЗНАЧЕННЯ
Authors: Кизимчук О. П. , Новак Д. С. , Романенко М. В. , Овсієнко Р. О. 
Published: August 2019

The development of “smart” materials and products from them is a relevant and promising research area today. It is taking into account the creation of new materials, the integration of conductive elements into them and the development of methods for creating a product which is able to feel, react and adapt to the environment. The goal of this work is the development of knitted fabric, which can be used for laying wires and embedded sensors in functional items for various purposes as well as the study of their properties.
Efektivitas Think Pair Share dengan Komik Ditinjau dari Kemampuan Memecahkan Masalah Matematis
Authors: Aziza Rosafika , Widodo Sri Adi , Agustito Denik 
Published: August 2019

Tujuan dari penelitian ini bertujuan untuk mengetahui efektifitas model pembelajaran Think Pair Share dengan komik matematika ditinjau dari kemampuan memecahkan masalah matematis. Metode penelitian yang digunakan adalah eksperimen dengan desain Posttest-Only Control Design. Ukuran sampel adalah 68 siswa yang diambil menggunakan teknik cluster random sampling. Instrumen yang digunakan dalam penelitian ini adalah Tes Pemecahan Masalah Matematika. Teknik analisis data digunakan dengan menggunakan uji statistik parametrik yaitu uji-t. Hasil penelitian menunjukkan bahwa pada kemampuan memecahkan masalah matematis, model pembelajaran model Think Pair Share dengan menggunakan komik matematika lebih efektif daripada pembelajaran Think Pair Share tanpa menggunakan komik. Berkaitan dengan ini komik dapat digunakan sebagai alternatrif dalam pemilihan media pada pembelajaran matematika.

Kata kunci: Think Pair Share, komik, kemampuan memecahkan masalah matematis.

ABSTRACT
The purpose of this study was to study the learning model of Paired Thinking Sharing with mathematical comics in terms of mathematical problem-solving skills. The research method used is an experiment with the design of Posttest-Only Control Design. The sample size was 68 students taken using cluster random sampling technique. The instrument used in this study is the mathematical problem-solving test. Data analysis technique used by using parametric statistical test is t-test. The results of the study show that , Think Pair Share learning model by using mathematical comics is more effective to solve mathematical problems than Think Pair Share learning without using comics. It is recommended to use comics as an alternative in selecting media in mathematics learning.
Keywords: Think Pair Share, comic, mathematical problem solving skill.