bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
Authors: Georgiev Kaloyan D. , Radeva-Ilieva Maya , Stoeva Stanila , Zhelev Iliya 
Published: September 2019

AbstractMethylxanthines, purine alkaloids found in plants, are found in beverages (coffee, tea, cocoa) and foods (chocolate and other cocoa-containing foods) commonly consumed worldwide. Members of this family include caffeine, theophylline and theobromine. Methylxanthines have a variety of pharmacological effects, and caffeine and theophylline are used as pharmaceuticals. Methylxanthines are metabolized in the liver predominantly by the enzyme CYP1A2. Their co-administration with CYP1A2 inhibitors may lead to pharmacokinetic interactions. Little is known about the possible drug interactions between caffeine and substrates of other CYP450 enzymes. In our study, methylxanthine fractions inhibited CYP3A4 in a concentration-dependent manner. Concomitant consumption of green tea with CYP3A4 substrates could increase the possibility of interactions, and this requires further clarification. The inhibition of CYP3A4 is not only due to the presence of catechin derivatives but methylxanthines may also contribute to this effect.
Intensivmedizinisches Management schwerer Infektionen bei Krebspatienten
Authors: Kochanek Matthias , Kiehl Michael , Liebregts Tobias 
Published: September 2019

AbstractDespite treatment options of cancer patients have been improved, the treatment of complications is usually very complex and often includes intensive care unit admission. Infections play a major role here. Risk patients and factors, timely detection of infections and septic states, diagnostic options and treatment options in the management of these cancer patients will be presented in this paper.
Magnetic Resonance Imaging in Pelvic Fractures – Part 2: Gaining Information and Clinical Therapeutic Relevance
Authors: Hackenbroch Carsten , Merz Charlotte , Palm Hans-Georg , Friemert Benedikt , Stuby Fabian , Lang Patricia ,   AG Becken III der DGU®
Published: September 2019

Abstract
Background Magnetic resonance and computed tomography (MRI, CT) has been known to compare the sensitivity for the detection of pelvic fractures with others. It is unclear whether MRI imaging beyond CT leads to therapy change. The aim of our study is to determine the information gained from MRI in the diagnosis of pelvic fractures and to reduce the effects on the form of therapy.
Patients and Methods In a retrospective, clinical study, 31 patients with pelvic fracture and CT and MRI imaging (median 81 ± 20 years, 22 female and 9 male) were examined. There was a classification according to AO classification for adequate or FFP classification for inadequate fractures. In addition, vascular, muscular, haematomatous and organic concomitant injuries as well as bone marrow edema and additional secondary findings requiring evaluation were evaluated. The type of therapy (conservative vs. surgical) and a possible type of therapy change were documented for each patient. Exact test according to Fisher was tested orienting.
Results Overall, MRI showed a greater fracture rate of pelvic fractures in 29% (n = 9) patients than CT. Four type I fractures according to FFP classification were identified as type II fractures and 4 type II fractures as type IV fractures. One type B1 fracture according to AO classification was found to be C2 fracture on MRI. Fisherʼs Exact Test found that the parameters “adequacy of trauma” and “fracture type change” by MRI were p = 0.38. MRI showed a total of 82 concomitant injuries, CT 31. Overall, MRI gained information in 75% (n = 24) of all patients examined. A change from conservative to operative after MRI took place in 2 patients. No patient was surgically changed from planned surgery to conservative. The extent to which MRI caused changes within one form of therapy (conservative, operative) could not be determined retrospectively. In 18% of patients with an inadequate fracture, however, according to the literature, the treatment regimen would have
changed pro forma.
Conclusion In summary, it can be stated that the MRI in our study provided an information gain in the case of adequate and inadequate pelvic fractures as well as their accompanying injuries and that a possible therapeutic relevance of this information gain could be obtained specially at the inadequate fractures showed.
Gemeinsam für die Pflege
Authors: Girts Sabine 
Published: September 2019

ZusammenfassungMit der Konzertierten Aktion Pflege (KAP) will die Bundesregierung den
Arbeitsalltag der Pflege und die Arbeitsbedingungen von beruflich
Pflegenden spürbar verbessern, sie entlasten und die Ausbildung in der Pflege
stärken. Hier erste Ergebnisse.
Zwischen Verzweiflung und Aufbruchsstimmung
Authors: Vogler Christine 
Published: September 2019

Zusammenfassung
Endlich ist er da, der Rahmenlehrplan. Mit ihm können die Schulen sich
vorbereiten auf die Inhalte, die sie ab 2020 anbieten. Christine Vogler,
Vizepräsidentin im DPR, beschreibt, warum die Schulen zwischen Kraftakt,
Verzweiflung und Euphorie schwanken.
Kolorektale Fremdkörper – eine Herausforderung für Patient und Arzt
Authors: Heil Jan , Bechstein Wolf Otto , Schnitzbauer Andreas , Habbe Nils 
Published: September 2019

Zusammenfassung
Hintergrund Kolorektale Fremdkörper sind ein nicht ungewöhnlicher Vorstellungsgrund in der Notaufnahme. Die häufig erst verspätete ärztliche Konsultation führt möglicherweise zu einer erhöhten Rate an Komplikationen. Vor jeder rektalen Manipulation sollte die Art des Fremdkörpers bekannt sein. Trotz Lokalisation im Rektum kann die Entfernung des Fremdkörpers schwierig sein und eine Narkose erfordern. Verletzungen sollten nach jeder Intervention ausgeschlossen werden.
Methoden Retrospektiv wurden die Fälle mit der Diagnose „Fremdkörper im Anus und Rektum (inkl. Sigmoid)“ zwischen 2002 und 2017 ausgewertet. Von 56 Patienten konnten 33 (59%) Patienten in die Studie eingeschlossen werden. Zusätzlich wurde eine Literaturrecherche mit den Suchbegriffen „colon AND foreign bod*“, „rectum AND foreign bod*“ und „colorectal AND foreign bod*“ in den Datenbanken PubMed (1623) und Cochrane Libary (17) sowie in der Suchmaschine Google Scholar (300) vorgenommen.
Ergebnisse Durchschnittlich erfolgte die Vorstellung nach 33 h. Eine Entfernung in der Notaufnahme gelang in 2 Fällen (6%). 31 Patienten (94%) benötigten eine Narkose. Eine notfallmäßige Laparotomie wurde in 3 Fällen (9%) vorgenommen. Komplikationen traten nicht auf. Die Entlassung erfolgte im Schnitt nach 1,5 d.
Schlussfolgerung Eine verspätete Vorstellung führt nicht zu einem komplizierteren Verlauf. Nach abschließender Rektoskopie ist eine weitere Bildgebung nicht erforderlich. Eine kurzzeitige Überwachung ist nach unauffälliger Klinik ausreichend.
Consumo de alimentos ultraprocessados em crianças atendidas pelo serviço de Atenção Básica na região Sul do Brasil
Authors: Libanio Isabela Faraco de Freitas , Correa Rafaela da Silveira , Monteiro Andresa de Souza , Vallandro Juliana Paludo 
Published: September 2019

Objetivo Investigar o consumo de alimentos ultraprocessados na alimentação das crianças brasileiras de 2 a 9 anos da região Sul do Brasil.
Metodologia Estudo transversal, no qual foram utilizados os dados públicos dos relatórios do Sistema de Vigilância Alimentar e Nutricional. Utilizou-se os dados de consumo alimentar de crianças de 2 a 9 anos dos anos de 2015 e 2016. Os grupos de alimentos utilizados para as análises foram: consumo de biscoitos, bolachas recheadas e guloseimas; bebidas adoçadas; macarrão instantâneo, salgadinho e biscoito de pacote e hambúrguer/e ou embutidos.
Resultados Foram analisados os dados de 22.761 crianças. Destas, 55,8% tinham idade entre 2 e 4 anos e 44,1% entre 5 e 9 anos. O grupo bebidas adoçadas (70,45%), seguido pela categoria macarrão instantâneo, salgadinhos e biscoitos de pacotes (63,25%) foram os que apresentaram maior média de consumo entre as duas faixas etárias. Quando comparado às prevalências do Brasil, o consumo de alimentos ultraprocessados foi significativamente maior na região Sul. Em relação à faixa etária, verificou-se que o consumo de alimentos ultraprocessados por crianças de 5 a 9 anos foi superior, quando comparadas às crianças de 2 a 4 anos (p < 0,002).
Conclusões Há necessidade da implementação de ações de saúde e educação efetivas que possam diminuir as prevalências do consumo de alimentos ultraprocessados no Brasil, especialmente na região Sul.
Palatal Abscess in a Pediatric Patient: Report of a Case
Authors: Sumer A. Pina , Celenk Peruze 
Published: September 2019

ABSTRACTThe palatal mass can pose a difficult diagnostic dilemma for the clinician. In differential diagnosis of the palatal mass, dental causes must be considered because they are so common. The palatal abscess typically represents the palatally directed drainage of an infection of pulpal or periodontal origin. The palatal abscess is often observed in the premolar-molar region and presents as a compressible mass or swelling usually lateral to the midline. This study reports the unusual case of a 5-year-old girl with a palatal abscess adjacent to the midline. (Eur J Dent 2008;2:291-293)
Harlequin Syndrome after Thoracoscopic Repair of a Child with Tracheoesophageal Fistula (TEF)
Authors: Wagner Richard , Lacher Martin , Merkenschlager Andreas , Markel Moritz 
Published: September 2019

AbstractHarlequin syndrome (HS) is a rare dysautonomia of the sympathetic nervous system leading to asymmetric facial flushing and sweating. In the literature, only a few cases of HS after thoracoscopic tracheoesophageal fistula (TEF) repair are reported. We report on a newborn with TEF who developed HS after thoracoscopic repair. On the first day of life, the girl (3,480 g, gestation age: 41 week) underwent thoracoscopic repair of a type C esophageal atresia (TEF; OR time 105 minute) without complications. The postoperative course was uneventful, the patient swallowed and thrived well and did not require esophageal dilatations. At 2 years of age, missing facial flushing, transpiration, and warming on the right side of her face during agitation were noticed. As no further intervention was required, the girl and her parents adapted well to the symptoms. Our report shows that the late onset of HS after the surgical procedure is unlikely a direct causal relation to the thoracoscopic operation but rather a shared embryological pathogenesis, like a neurocristopathy.
Reconstruction of Lower Extremity Defects Using the Serratus Anterior Free Flap: A Systematic Review and Retrospective Case Series
Authors: Karir Aneesh , Stein Michael J. , Shiga Sarah , Zhang Jing 
Published: September 2019

Abstract
Background Free tissue transfer is the most common modality for distal third lower extremity reconstruction, yet complication rates remain high. The serratus anterior muscle free flap, which can be harvested alone or as a chimeric flap, is a robust and reliable option that remains the primary modality for distal third lower extremity defects at our institution. The objective of this study was to perform a systematic review of lower extremity reconstruction with the serratus anterior free flap and provide a retrospective review of cases at our institution.
Methods A systematic review of the literature was conducted using PubMed, Embase, and Cochrane Library (PROSPERO CRD42018110692). Articles reporting reconstruction of lower extremity and foot defects using serratus anterior free flaps in adults were included. A retrospective cohort study of serratus anterior free flaps was then performed from 2012 to 2018 at our institution.
Results Thirty-seven articles meeting inclusion criteria provided data on 198 flaps: 125 (63%) serratus-only flaps and 73 (37%) chimeric flaps based on the subscapular axis. Among the serratus-only flaps, defects were primarily due to chronic wounds (51%) or acute infections (33%). Flap survival rate was 97%, and the major and minor complication rates were 5 and 9%, respectively. Of the 10 cases included in the case series, flap survival rate was 100%, there were no major complications, and the minor complication rate was 44%. The average time to flap healing was 95 days and average lower extremity functional scale score was 58/80 among five patients.
Conclusion Serratus anterior muscle free flaps are a versatile and reliable option for distal third lower extremity reconstruction.
Esophagojejunal anastomotic leak managed with self expandable metallic stent
Authors: Annapillai Arvind Madurandagam , Ramachandran Biggs Saravanan , Ponniah Senthilkumar , V. Hemamala , B. Kesavan , Karunakaran Premkumar , Raju Prabhakaran , G. Manoharan , Murugesan Chandramohan Servarayan , Muhammed Mohammed Ali 
Published: September 2019

ABSTRACTEsophagealjejunal anastomotic leak after gastrectomy is a serious surgical emergency with high mortality. This report describes a 57-year-old male with esophagojejunal anastomotic leak following total gastrectomy for gastric cancer and was managed successfully with self-expandable metallic stent. To our knowledge this is the first such report from India. This case report highlights the need of interdisciplinary coordination in managing this difficult clinical situation. Endotherapy with self-expandable metallic stent (SEM) provided twin benefits of improving respiratory embarrassment and the joy of eating. Therapy of such difficult cases must be individualized; however, and SEM stent usage is a viable option (J Dig Endcsc 2013;4(1):13–15)
Simulation of a folded airbag inflating underwater with IMM method
Authors: Chen Yan , Chen Guo-Ping , He Huan 
Published: September 2019

Abstract
Folded airbags have a wide range of applications in underwater salvage. Considering the influence of water pressure and inflation parameters, whether the airbag can be rapidly and steadily inflated is the key problem. Numerical simulations of the airbag can be used as a powerful tool to reduce the development time. To enable the behavior of the flotation bag to be accurately modeled, a combined Euler-Lagrange analysis was carried out in the finite element software MSC.Dytran using a general coupling surface. Two finite element models of the same cylinder flotation bag were established using the Initial Metric Method (IMM). One model is called Initial state and the other is called Reference state. The IMM folding technique can avoid negative deform of membrane elements significantly especially the final shape of the deformed bag. Besides, the relationships between the aeration rate and airbag parameters (volume and pressure) were discussed.
Hybrid energy harvesting from the natural wind and magnetic field
Authors: Xu Xueping , Han Qinkai , Chu Fulei 
Published: September 2019

Abstract
This paper proposes a hybrid energy harvester scheme from the natural wind and magnetic field. A prototype is fabricated with a piezoelectric sheet and a Galfenol substrate cantilever. The energy harvester from natural wind not the tunnel wind is simulated and verified by the experiment results. Moreover the performances of hybrid energy harvester with respect to the single energy collection are in-depth investigated. The optimal output criterion is defined and the hybrid output voltages for the optimal parameters can be predicted. The optimal ranges of magnetic field intensity for different wind speeds are presented. Experiment results demonstrate the superiority of the hybrid energy harvester over individual harvesters. Suggestions for the rational design of this hybrid energy harvester are illustrated. This paper provides a feasible solution for the hybrid energy harvester from natural wind and magnetic field, which can be significant for improving the capacity and reliability in energy harvesting.
Prediction of the sound insulation of panel structures based on the virtual testing room
Authors: Wang Gang , Li Guofang , Feng Zhihua , Ni Junfang 
Published: September 2019

Abstract
The sound transmission through an elastically bounded panel between rooms is presented in this paper. A fully-coupled modal is used to investigate the effect of elastic boundary of the panel on the sound transmission by using Spectro-Geometric Method (SGM) which is a meshless and parametric modeling technique for general vibro-acoustic analysis. Unlike the traditional modal superposition methods, the continuity of the normal velocities is faithfully enforced on the interfaces between the flexible panel and the (interior and exterior) acoustic media. The sound insulation structures can represent a simple panel or a complex structure with various structural and/or acoustical design features. This model can be effectively used to virtually test the acoustic performance of sound insulation designs under different environments and application conditions.
Numerical simulation of overtopping in the earth-filled dam based on material point method
Authors: Yang Yong-Sen , Qiu Liu-Chao , Tian Lei , Li Jing-Jun , Han Yu 
Published: September 2019

Abstract
Dams breach by overtopping is a serious natural disaster. Numerical simulation, as a efficient research method, is widely used to study the failure mechanism and predict the destroyed process of earth dams. Traditional numerical methods such as the finite element method (FEM) only provide the capacity of small deformation analyses due to mesh distortion. The Material Point Method (MPM), a mesh-free method, has been worked well for large deformation analyses. In this paper, a double-point MPM is introduced to analysis the failure process of earth-filled dams due to overtopping. Finally, it shows that the MPM predicts the flow propagation, the development of breach cross section and breach longitudinal profile well. Moreover, MPM provides an alternative method for the risk assessment of dam breach.
The phase-change heat conduction analysis during solidification processes by a hybrid generalized FDM
Authors: Liu Hui , Lei Jun , Xu Yanjie 
Published: September 2019

Abstract
In this paper, the single-domain enthalpy model is adopted for heat transfer analysis of phase change during solidification processes. The resulting second-order parabolic partial differential equations (PDEs) with varying thermophysical coefficients is numerically solved by a hybrid generalized finite difference method (GFDM) under mixed boundary conditions. The spatial derivatives in the PDEs are approximated by the Taylor series expansions combining with the moving-least squares technique. The temporal derivative is evaluated with a six-point symmetric difference by the classical Crank-Nicholson technique. The Newton-Raphson iteration method is used to solve the resulting nonlinear algebraic equations. Finally, the transient temperature field and the moving phase-change interface are obtained by analysing the nodal temperature distribution. Several examples are presented for verify the stability and effectiveness of this meshless method.
Modeling and simulation of the structural and electrical characteristics for a polarized piezoelectric sensor actuator
Authors: Zhang Chong , Shan Xiaobiao , Peng Gaoliang , Xie Tao , Dong Xin 
Published: September 2019

Abstract
The present work aims to design a new polarized piezoelectric sensor actuator. This sensor actuator not only can achieve sensing and execution at the same time, but also has the advantages of small size and high integration. A mathematical model of stack displacement with input voltage and number of layers was established. The relationship between the charge generated by quartz crystal and external force was numerically analysed. The static and modal analysis of the structure were carried out to obtain the measured force range and the maximum working frequency. The transient simulation is used to verify the follow-up law of the actuator to the alternating signal. The Electric field interference analysis of the piezoelectric sensor actuator was performed to eliminate the interference from the electric field generated by the actuator. The results show that the measured force range of the actuator is up to 1 kN, with the maximum working frequency is 1000 Hz, and the actuator can follow the drive voltage signal well, with an almost negligible electric field interference in the sensor part. This paper provides a new method and theory for the study of self-sensing actuators.
Nonlinear breathing vibrations of a circular mesh antenna based on a equivalent model of a composite laminated circular cylindrical shell with membranes
Authors: Liu T , Zhang W , Zheng Y , Liu H 
Published: September 2019

Abstract
This paper is focused on the nonlinear breathing vibrations of the circular mesh antenna based on a composite laminated circular cylindrical shell with radially pre-stretched membranes at both ends and clamped along a generatrix. The finite element model of the circular mesh antenna are established, we study the effects of different mesh stiffness on the first six orders frequencies. It is found that there is an approximate threefold relationship between the first-order frequency and the forth-order frequency. Based on the particular integer multiple relationship, we can conclude that there is the 1:3 resonance between the first-order and the forth-order vibrations of the circular mesh antenna. The method of multiple scales is employed to obtain the four-dimensional nonlinear averaged equation based on the two degree of freedom non-autonomous nonlinear equations of the equivalent model of circular mesh antenna and the 1:3 internal resonance is considered here. Then, based on the numerical method, the chaotic dynamics of the equivalent model of circular mesh antenna are studied by the bifurcation diagrams, the phase portraits, the waveforms, the power spectrums and the Poincaré map. The temperature parameter excitation shows that the complex chaotic phenomena occur under the certain initial conditions.
Effect of Shear Flow on Flow Characteristics of The PTC Cylinder
Authors: Zhang Dahai , Li Tianjiao , Feng Lei , Huang Wenxiu , Ji Chunning 
Published: September 2019

Abstract
In this paper, FLUENT software was used to simulate the flow characteristics of the passive turbulence control (PTC) cylinder in shear flow field. In the range of Reynolds number 3.5×104 ⩽Re⩽7.0×104, shear rate (K) and Reynolds number (Re) can affect the dynamic characteristics of the PTC cylinder. The results show that, in shear flow field, the trends of CDrms and CDrms of the PTC cylinder are the same as those in uniform flow field. When the parameter K is constant, CDrms and CDrms decrease with the increase of the parameter Re. When Re is constant, both CDrms and CDrms decrease with the increase of K. When Reynolds number is 3.5×104, the results about the wake shape of the PTC cylinder in the shear flow field show that the characteristics of the incoming flow will influence the pressure distribution to a greater extent and offset the influence of partial randomness to a certain extent. Compared with the randomness of KH instability of shear layer in the symmetric flow field, the difference of pressure distribution on the upper and lower surfaces of a cylinder in the shear flow field makes it easier to excite the periodic vorticity phenomenon.