bluuebunny/crossref_metadata_2025_split huggingface dataset:
A wavelet-based decomposition method for a robust extraction of pulse rate from video recordings
Authors: Finžgar Miha , Podržaj Primož 
Published: November 2018

Background
Remote photoplethysmography (rPPG) is a promising optical method for non-contact assessment of pulse rate (PR) from video recordings. In order to implement the method in real-time applications, it is necessary for the rPPG algorithms to be capable of eliminating as many distortions from the pulse signal as possible.

Methods
In order to increase the degrees-of-freedom of the distortion elimination, the dimensionality of the RGB video signals is increased by the wavelet transform decomposition using the generalized Morse wavelet. The proposed Continuous-Wavelet-Transform-based Sub-Band rPPG method (SB-CWT) is evaluated on the 101 publicly available RGB facial video recordings and corresponding reference blood volume pulse (BVP) signals taken from the MMSE-HR database. The performance of the SB-CWT is compared with the performance of the state-of-the-art Sub-band rPPG (SB).

Results
Median signal-to-noise ratio (SNR) for the proposed SB-CWT ranges from 6.63 to 10.39 dB and for the SB from 4.23 to 6.24 dB. The agreement between the estimated PRs from rPPG pulse signals and the reference signals in terms of the coefficients of determination ranges from 0.81 to 0.91 for SB-CWT and from 0.41 to 0.47 for SB. All the correlation coefficients are statistically significant (p < 0.001). The Bland–Altman plots show that mean difference range from 5.37 to 1.82 BPM for SB-CWT and from 22.18 to 18.80 BPM for SB.

Discussion
The results show that the proposed SB-CWT outperforms SB in terms of SNR and the agreement between the estimated PRs from RGB video signals and PRs from the reference BVP signals.
IVIg‐induced plasmablasts in patients with Guillain‐Barré syndrome
Authors: Brem Maarten D. , Jacobs Bart C. , van Rijs Wouter , Fokkink Willem Jan R. , Tio‐Gillen Anne P. , Walgaard Christa , van Doorn Pieter A. , IJspeert Hanna , van der Burg Mirjam , Huizinga Ruth 
Published: November 2018

AbstractObjectiveThe Guillain–Barré syndrome (GBS) is an acute, immune‐mediated disease of peripheral nerves. Plasmablasts and plasma cells play a central role in GBS by producing neurotoxic antibodies. The standard treatment for GBS is high‐dose intravenous immunoglobulins (IVIg), however the working mechanism is unknown and the response to treatment is highly variable. We aimed to determine whether IVIg changes the frequency of B‐cell subsets in patients with GBS.MethodsPeripheral blood mononuclear cells were isolated from 67 patients with GBS before and/or 1, 2, 4, and 12 weeks after treatment with high‐dose IVIg. B‐cell subset frequencies were determined by flow cytometry and related to serum immunoglobulin levels. Immunoglobulin transcripts before and after IVIg treatment were examined by next‐generation sequencing. Antiglycolipid antibodies were determined by ELISA.ResultsPatients treated with IVIg demonstrated a strong increase in plasmablasts, which peaked 1 week after treatment. Flow cytometry identified a relative increase in IgG2 plasmablasts posttreatment. Within IGG sequences, dominant clones were identified which were also IGG2 and had different immunoglobulin sequences compared to pretreatment samples. High plasmablast frequencies after treatment correlated with an increase in serum IgG and IgM, suggesting endogenous production. Patients with a high number of plasmablasts started to improve earlier (P = 0.015) and were treated with a higher dose of IVIg.InterpretationHigh‐dose IVIg treatment alters the distribution of B‐cell subsets in the peripheral blood of GBS patients, suggesting de novo (oligo‐)clonal B‐cell activation. Very high numbers of plasmablasts after IVIg therapy may be a potential biomarker for fast clinical recovery.
Ionic‐Liquid Gating of InAs Nanowire‐Based Field‐Effect Transistors
Authors: Lieb Johanna , Demontis Valeria , Prete Domenic , Ercolani Daniele , Zannier Valentina , Sorba Lucia , Ono Shimpei , Beltram Fabio , Sacépé Benjamin , Rossella Francesco 
Published: November 2018

AbstractHere, the operation of a field‐effect transistor based on a single InAs nanowire gated by an ionic liquid is reported. Liquid gating yields very efficient carrier modulation with a transconductance value 30 times larger than standard back gating with the SiO2/Si++ substrate. Thanks to this wide modulation, the controlled evolution from semiconductor to metallic‐like behavior in the nanowire is shown. This work provides the first systematic study of ionic‐liquid gating in electronic devices based on individual III–V semiconductor nanowires: this architecture opens the way to a wide range of fundamental and applied studies from the phase transitions to bioelectronics.
Advanced Collagen‐Based Biomaterials for Regenerative Biomedicine
Authors: Lin Kaili , Zhang Dawei , Macedo Maria Helena , Cui Wenguo , Sarmento Bruno , Shen Guofang 
Published: November 2018

AbstractIn recent decades, collagen is one of the most versatile biomaterials used in biomedical applications, mostly due to its biomimetic and structural composition in the extracellular matrix (ECM). Several attempts are proposed for designing innovative collagen‐based biomaterials and applying them in tissue regeneration. The regeneration of different tissues is prompted by different types and diverse physical forms of collagen‐based biomaterials prepared by various methods. Based on such concepts, the source, structure, and classification of collagen are briefly introduced in this review. Here, the commonly used physical forms and modification methods of collagen‐based biomaterials are reviewed, including hydrogels, scaffolds, and microspheres, followed by their applications in the regeneration of tissues and organs. Important proof‐of‐concept examples are described to demonstrate the outcomes on material characteristics, cellular reactions, and tissue regeneration. A concise assessment of the limitations that still exist and the developing trends in the future of collagen‐based biomaterials are put forward.
Colloidal Pixel‐Based Micropatterning Using Uniform Janus Microparticles with Tunable Anisotropic Particle Geometry
Authors: Han Sang Woo , Choi Song‐Ee , Chang Douglas H. , Lee Duho , Kim Bohyun , Yang Hakyeong , Seo Minjeong , Kim Jin Woong 
Published: November 2018

AbstractA new platform for designing 2D colloidal arrays by using Janus microparticles (JMPs) with tunable anisotropic particle geometry is introduced. The JMPs are synthesized by the photopolymerization of biphasic emulsion droplets produced by capillary‐based microfluidics while adjusting the spreading coefficient between −4.4 and −7.2 mN m−1. The unidirectional rubbing of JMPs leads to their exact positioning in the stencil holes. The ratio of the hole diameter to the bigger bulb diameter of JMPs, ranging from 1.05–1.16, is critical for maximizing the positioning rate. When the anisotropic geometry factor is near zero, a standing particle configuration with a protrusion in the stencil hole is obtained more efficiently due mainly to the enhanced steric constraint. Finally, it is demonstrated that different types of JMPs with controlled sizes and geometries can be arrayed at specific hole sites of the stencil, thus enabling development of a colloidal pixel‐based micropatterning technology.
Photoquantum Hall Effect and Light‐Induced Charge Transfer at the Interface of Graphene/InSe Heterostructures
Authors: Bhuiyan Mahabub A. , Kudrynskyi Zakhar R. , Mazumder Debarati , Greener Jake D. G. , Makarovsky Oleg , Mellor Christopher J. , Vdovin Evgeny E. , Piot Benjamin A. , Lobanova Inna I. , Kovalyuk Zakhar D. , Nazarova Marina , Mishchenko Artem , Novoselov Kostya S. , Cao Yang , Eaves Laurence , Yusa Go , Patanè Amalia 
Published: November 2018

AbstractThe transfer of electronic charge across the interface of two van der Waals crystals can underpin the operation of a new class of functional devices. Among van der Waals semiconductors, an exciting and rapidly growing development involves the “post‐transition” metal chalcogenide InSe. Here, field effect phototransistors are reported where single layer graphene is capped with n‐type InSe. These device structures combine the photosensitivity of InSe with the unique electrical properties of graphene. It is shown that the light‐induced transfer of charge between InSe and graphene offers an effective method to increase or decrease the carrier density in graphene, causing a change in its resistance that is gate‐controllable and only weakly dependent on temperature. The charge transfer at the InSe/graphene interface is probed by Hall effect and photoconductivity measurmentes and it is demonstrated that light can induce a sign reversal of the quantum Hall voltage and photovoltaic effects in the graphene layer. These findings demonstrate the potential of light‐induced charge transfer in gate‐tunable InSe/graphene phototransistors for optoelectronics and quantum metrology.
Symmetry‐Breaking Response of Azo Molecular Glass Microspheres to Interfering Circularly Polarized Light: From Shape Manipulation to 3D Patterning
Authors: Hsu Chungen , Xu Zeda , Wang Xiaogong 
Published: November 2018

AbstractThis work investigates symmetry‐breaking deformation of azo molecular glass microspheres induced by interfering circularly polarized light, and related particle shape manipulation as well as 3D patterning. The isolated microspheres and microsphere monolayers are obtained from an azo molecular glass (IA‐Chol) by the solution dispersion method and soft‐lithography, respectively. Unique symmetry‐breaking deformation is observed for the microspheres upon exposure to the spatially modulated light field, which is produced by interference of two orthogonally polarized laser beams with the right‐circular polarization (RCP) and left‐circular polarization (LCP). Two distinct deformation modes are developed upon the irradiation with the interfering beams in RCP:LCP and LCP:RCP superposition manners, respectively. The unique morphologies with the symmetry‐breaking characteristics are caused by mass transfer induced by the light irradiation. For the microsphere monolayers, the deformations of the microspheres not only capture and record the polarization states of the light field, but also create various surface patterns combining the symmetry‐breaking deformations and periodic surface modulation. A variety of unique surface patterns are obtained by irradiation with the interfering circularly polarized waves with the orthogonal and also the same‐handed polarizations. The material and methodology developed in this study are promising for applications in sensing, optics, responsive surfaces, and others.
Gold Nanoparticles with Antibiotic‐Metallopolymers toward Broad‐Spectrum Antibacterial Effects
Authors: Yang Peng , Pageni Parasmani , Rahman Md Anisur , Bam Marpe , Zhu Tianyu , Chen Yung Pin , Nagarkatti Mitzi , Decho Alan W. , Tang Chuanbing 
Published: November 2018

AbstractBacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug‐resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer‐antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β‐lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β‐lactamase. This nanoparticle‐based antibiotic‐metallopolymer system exhibits an excellent broad‐spectrum antibacterial effect, particularly for Gram‐negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.
Capillary Tube Based Molecular Diagnostic Test for Naked Eye Detection of Antibiotic Resistant Bacteria
Authors: Choi Bo Ram , Cho Juyeon , Kim Jooyeong , Kim Ji Su , Kim Kyungjin , Lee Hyukjin 
Published: November 2018

AbstractAntibiotic resistance bacteria (ARB) are a rising threat to public health. To prevent the emergence of antibiotic resistance strains of bacteria, selectively prescribing antibiotics is of the utmost importance. Under infection control in hospitals, rapid and accurate diagnosis of antibiotic resistant bacteria is highly critical. This study shows a new diagnostic platform for naked‐eye detection of antibiotics resistant bacteria using a capillary tube based optical detection method. For specific detection of target ARB, DNA hydrogel formation by isothermal amplification of complementary target (DhITACT) system is incorporated with magnetic beads (MBs). To facilitate naked‐eye optical detection, a molecular probe is immobilized on the surface of MBs. After selectively capturing target to the probe, generation of long DNA strands is achieved through isothermal rolling circle amplification (RCA). Physical entanglement of amplified DNA products triggers rapid interparticle aggregation among MBs. Using this phenomenon, a capillary tube‐based naked eye detection test is developed. This system offers facile optical detection of ARB with minimal procedures to support its wide use in a clinical set‐up.
Molecular Engineering of Monodisperse SnO2 Nanocrystals Anchored on Doped Graphene with High‐Performance Lithium/Sodium‐Storage Properties in Half/Full Cells
Authors: Wang Heng‐guo , Wu Qiong , Wang Yinghui , Wang Xiao , Wu Lanlan , Song Shuyan , Zhang Hongjie 
Published: November 2018

AbstractThe fabrication of ultrasmall and high‐content SnO2 nanocrystals anchored on doped graphene can endow SnO2 with superior electrochemical properties. Herein, an effective strategy, involving molecular engineering of a layer‐by‐layer assembly technique, is proposed to homogeneously anchor SnO2 nanocrystals on nitrogen/sulfur codoped graphene (NSGS), which serves as an advanced anode material in lithium/sodium‐ion batteries (LIBs/SIBs). Benefiting from novel design and specific structure, the optimized NSGS for LIBs displays high initial capacity (2123.9 mAh g−1 at 0.1 A g−1), long‐term cycling performance (only 0.8% loss after 500 cycles), and good rate capability (477.4 mAh g−1 at 5 A g−1). In addition, the optimized NSGS for SIBs also delivers high initial capacity (791.7 mAh g−1 at 0.1 A g−1) and high reversible capacity (180.2 mAh g−1 after 500 cycles at 0.5 A g−1). Meanwhile, based on the detailed analysis of phase transition and electrochemical reaction kinetics, the reaction mechanisms of NSGS in LIBs and SIBs as well as the distinction in LIBs/SIBs are clearly articulated. Notably, to further explore the practical application, Li/Na+ full cells are also assembled by coupling the optimized NSGS anode with LiCoO2 and Na3V2(PO4)3/C cathodes, respectively.
Assessment of the Physicochemical Properties and Oxidative Stability of Kernel Fruit Oil from the Acrocomia totai Palm Tree
Authors: Souza Gredson Keiff , Diório Alexandre , Johann Gracielle , Gomes Maria Carolina Sérgi , Pomini Armando Mateus , Arroyo Pedro Augusto , Pereira Nehemias Curvelo 
Published: November 2018

AbstractThis study investigated the effects of variations in oil contents and fatty‐acid composition, density, viscosity, acid values, saponification values, specific oxidative stability, and antioxidant concentration of Acrocomia totai kernel oil during fruit maturation. Fatty acids were quantified using 1H nuclear magnetic resonance (NMR) spectroscopy, gas chromatograph‐flame‐ionization detector (GC‐FID), and Fourier transform Raman (FT‐Raman) spectroscopy analyses. The results showed that all physicochemical characteristics and oil composition changed during the ripening stage. The CG‐FID analysis showed a reduction in the unsaturated fatty‐acid content (from 78.8% to 22.1%), with a proportional increase in the saturated fatty‐acid contents (from 21.6% to 77.9%). The difference in the fatty‐acid composition was confirmed by analysis of the 1H NMR and FT‐Raman spectra. The degree of unsaturation was calculated to determine the oxidative stability of oil. These results suggest that the fruit's maturation contributes to the specific oxidative stability. The antioxidant concentration revealed higher contents of carotenoids in the ripe fruit (0.16 mg of carotenoid per 100 gKERNEL) when compared to the unripe fruit (0.05 mg of carotenoid per 100 gKERNEL). In the total phenolics analysis, there was no change in concentration over ripening time. These results show that kernel oil has physicochemical properties comparable with high‐quality commercial vegetable oils, suggesting that it is a promising alternative to conventional vegetable oils.
Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential
Authors: Firdaus Jannat Ul , Habib Anwar , Siddiqui Nadeem , Alam Ozair , Naim Mohd. Javed , Partap Sangh , Sahu Meeta 
Published: November 2018

AbstractA series of newer benzothiazolotriazine derivatives (4a–k) was designed, synthesized, and characterized as anticonvulsant agents against the two classically used MES and scPTZ animal models. The synthesized derivatives were tested in vivo in both the animal models, followed by a neurotoxicity study by the rotarod method. Compound 4e, 8‐chloro‐4‐(2‐chlorocyclohexa‐1,5‐dien‐1‐yl)‐2‐((4‐methoxybenzyl)thio)‐10aH‐benzo[4,5]thiazolo[3,2a][1,3,5]triazine was found most promising among the series in both the animal models, with no neurotoxicity. From this it may be confirmed that the presence of a methoxy (OCH3) group at the lipophilic aryl ring was showing high anticonvulsant potency. In the molecular modeling study, compound 4e (docking score = −8.70) showed important hydrogen bond interaction with the amino acids LYS 329, SER 137, GLY 136 and π–π interactions with PHE 189 at the active site of GABA‐AT. These derivatives can be further explored for the development of newer/novel anticonvulsant agents.
Solid‐State Carbon Dots with Efficient Cyan Emission towards White Light‐Emitting Diodes
Authors: Wang Deyin , Khan Waheed U. , Wang Yuhua 
Published: November 2018

AbstractEfficient cyan‐emitting solid carbon dots (CDs) were synthesized via a one‐pot hydrothermal method. The obtained solid CDs show a broad absorption from 270–460 nm with a maximum around 400 nm, and emit intense cyan light around 500 nm with an internal photoluminescence quantum efficiency of 34.1 % under 400 nm excitation. The emission maximum of the solid CDs remains unchanged under 320–400 nm excitations. Compared with dilute aqueous of CDs (2.5 mg mL−1), the emission of solid CDs shows an obvious red‐shift of 50 nm. The red‐shift is caused by resonant energy transfer due to larger spectral overlap and smaller interparticle distance, together with a new surface state caused by aggregation in solid CDs. A lamp with white LEDs was fabricated by dropping a mixture of solid CDs, CaAlSiN3:Eu2+ and silicon resin on the top of a near‐ultraviolet LED chip. Under an operating current of 20 mA, the as‐fabricated white LED generates a high‐quality, warm white light with a color rendering index of 86.1, a color temperature of 4340 K, and a luminescence efficiency of 31.3 lm W−1.
Encapsulating Au‐Fe3O4 Nanodots into AIE‐active Supramolecular Assemblies: Ambient Visible‐light Harvesting “Dip‐Strip” Photocatalyst for C−C/C−N Bond Formation Reactions
Authors: Kaur Harpreet , Kaur Mandeep , Walia Preet Kamal , Kumar Manoj , Bhalla Vandana 
Published: November 2018

AbstractThe present study demonstrates the development of a supramolecular porous ensemble consisting of hetero‐oligophenylene derivative 6 and Au‐Fe3O4 nanodots. Supramolecular assemblies of AIE‐active hetero‐oligophenylene derivative 6 served as reactors for the generation of Au‐Fe3O4 nanodots. The as prepared supramolecular ensemble functioned as an efficient recyclable photocatalytic system for C(sp2)−H bond activation of anilines for the construction of quinoline carboxylates. Interestingly, the “dip catalyst” prepared by depositing PTh‐co‐PANI‐6: Au‐Fe3O4 nanodots on a filter paper served as a recyclable strip (up to 10 cycles) for C−C/C−N bond formation reaction.
Synthesis and Magnetic Properties of (Pyrrolidin‐1‐oxyl)–(Nitronyl Nitroxide)/(Iminonitroxide)‐Dyads
Authors: Tsujimoto Haruki , Suzuki Shuichi , Kozaki Masatoshi , Shiomi Daisuke , Sato Kazunobu , Takui Takeji , Okada Keiji 
Published: November 2018

AbstractUnlike extensively studied diradicals linked by π‐conjugated systems, only a few studies have investigated weakly coupled diradicals linked by an sp3 carbon atom. Herein, we prepared pyrrolidin‐1‐oxyl–(nitronyl nitroxide)‐dyad 5 and pyrrolidin‐1‐oxyl–iminonitroxide‐dyad 6. From the observed temperature dependence of the magnetic susceptibility, 5 and 6 were determined to be in singlet ground states with 2Jintra/kB=−35.2 K and −13.6 K, respectively. From these results and theoretical calculations of related diradicals, the spin‐polarization model counting the small spin density of the sp3 carbon atom could be used as a spin‐prediction model.
A beta‐binomial mixed‐effects model approach for analysing longitudinal discrete and bounded outcomes
Authors: Najera‐Zuloaga Josu , Lee Dae‐Jin , Arostegui Inmaculada 
Published: November 2018

AbstractPatient‐reported outcomes (PROs) are currently being increasingly used as primary outcome measures in observational and experimental studies since they inform clinicians and researchers about the health‐status of patients and generate data to facilitate improved care. PROs usually appear as discrete and bounded with U, J, or inverse J shapes, and hence, exponential family members offer inadequate distributional fits. The beta‐binomial distribution has been proposed in the literature to fit PROs. However, the fact that the beta‐binomial distribution does not belong to the exponential family limits its applicability in the regression model context, and classical estimation approaches are not straightforward. Moreover, PROs are usually measured in a longitudinal framework in which individuals are followed up for a certain period. Hence, each individual obtains several scores of the PRO over time, which leads to the repeated measures and defines the correlation structure in the data. In this work, we have developed and proposed an estimation procedure for the analysis of correlated discrete and bounded outcomes, particularly PROs, by a beta‐binomial mixed‐effects model. Additionally, we have implemented the methodology in thePROregpackage in R. Because there are similar approaches in the literature to address the same issue, this work also incorporates a comparison study between our proposal and alternative methodologies commonly implemented in R and shows the superior performance of our estimation procedure. This paper was motivated by the analysis of the health‐status of patients with chronic obstructive pulmonary disease, where the main objective is the assessment of risk factors that may affect the evolution of the disease. The application of the proposed approach in the study leads to clinically relevant results.