bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma
Authors: Nejo Takahide , Matsushita Hirokazu , Karasaki Takahiro , Nomura Masashi , Saito Kuniaki , Tanaka Shota , Takayanagi Shunsaku , Hana Taijun , Takahashi Satoshi , Kitagawa Yosuke , Koike Tsukasa , Kobayashi Yukari , Nagae Genta , Yamamoto Shogo , Ueda Hiroki , Tatsuno Kenji , Narita Yoshitaka , Nagane Motoo , Ueki Keisuke , Nishikawa Ryo , Aburatani Hiroyuki , Mukasa Akitake , Saito Nobuhito , Kakimi Kazuhiro 
Published: May 2019

Abstract
Immune-based therapies have shown limited efficacy in glioma thus far. This might be at least in part due to insufficient numbers of neoantigens, thought to be targets of immune attack. In addition, we hypothesized that dynamic genetic and epigenetic tumor evolution in gliomas might also affect the mutation/neoantigen landscape and contribute to treatment resistance through immune evasion. Here, we investigated changes in the neoantigen landscape and immunologic features during glioma progression using exome and RNA-seq of paired primary and recurrent tumor samples obtained from 25 WHO grade II–IV glioma patients (glioblastoma, IDH-wild-type, n = 8; grade II–III astrocytoma, IDH-mutant, n = 9; and grade II–III oligodendroglioma, IDH-mutant, 1p/19q-codeleted, n = 8). The number of missense mutations, predicted neoantigens, or expressed neoantigens was not significantly different between primary and recurrent tumors. However, we found that in individual patients the ratio of expressed neoantigens to predicted neoantigens, designated the “neoantigen expression ratio,” decreased significantly at recurrence (P = 0.003). This phenomenon was particularly pronounced for “high-affinity,” “clonal,” and “passenger gene–derived” neoantigens. Gene expression and IHC analyses suggested that the decreased neoantigen expression ratio was associated with intact antigen presentation machinery, increased tumor-infiltrating immune cells, and ongoing immune responses. Our findings imply that decreased expression of highly immunogenic neoantigens, possibly due to persistent immune selection pressure, might be one of the immune evasion mechanisms along with tumor clonal evolution in some gliomas.
“I Have Become a Brother of Jackals”: Evolutionary Psychology and Suicide in the Book of Job
Authors: Cho Paul K.-K. 
Published: May 2019

Abstract
Job compares himself time and again to defeated and trapped animals in the poetic core of the Book of Job. God, in responding to Job, describes in loving detail, as would a proud parent her children, the animals that populate creation. This paper argues that the Joban Poet uses animal imagery to allow Job to express an evolving sense of his traumatized self and the world and God to affirm the beauty and vitality of creation and, indirectly, also of Job who has come to think of himself as a trapped and hunted animal.
Conditions for Creativity in Conversation
Authors: Pauley John A. 
Published: May 2019

Abstract
This essay begins by demonstrating how conversations can end before they have a chance to authentically begin. Conversations are stultified by patterns in the human ecology. The first pattern identified is “self-obliviousness” in conversation. “Self-obliviousness” is then tied to patterns of both radical self-assurance and self-diminishment. The underlying idea and argument is that adequate self-awareness is a necessary condition for (authentic) conversation and this condition is only met as human beings recognize their own selves as relational. The argument then turns to remedies to the pattern. Metacognition as exercised in relation to literary art can reveal the conditions for identifying and recognizing the damaging patterns. By the end of the essay the conditions for creativity in conversation are conflated with the formation of empathetic dispositions and these are only possible through understanding the self in equal relation to other selves. The arguments and examples are from contemporary United States Culture, but the damaging patterns can easily be recognized as elements of the human condition generally.
Raising Questions, Cutting Fingers: Chan Buddhism and the Cultivation of Creativity through Ritual Dialogues
Authors: Capra Rudi 
Published: May 2019

Abstract
The present paper identifies creativity as a crucial component in the pedagogical process envisaged by Chan masters in the Song era. In particular, the paper considers ritual dialogues between masters and students involving questions and answers (wenda 問答) taken from the renowned collection known as the Blue Cliff Record (biyan lu 碧巖錄).
The first section is concerned with the definition of creativity and its role within the contextual framework of Chan pedagogy in the Song era. The second section analyses some significant ritual dialogues included in the Blue Cliff Record with the aim of exploring a variety of different creative expressions in the considered Chan narratives. The third and last section illustrates how the ritualized performance of dialogical encounters, and by extension the use of gongan literature, entails and promotes the recourse to creativity as a functional strategy in Chan practice.
The Dialogue between Painting, Mindfulness and Dufrenne’s Aesthetics
Authors: Fitzpatrick Colleen 
Published: May 2019

Abstract
This paper examines the dialogical relationship between painting and mindfulness. This premise is explored with reference to the aesthetics of Mikel Dufrenne. Dufrenne’s arguments make use of a number of features that characterise mindful practice and reflect mindfulness philosophy. Dufrenne’s phenomenology of aesthetic experience centres on being present, focused, non-judgemental and attentive to the aesthetic object in order to realise its signification. These concepts are also given primary importance in Buddhist philosophy of mindfulness. Dufrenne’s theory lends itself ideally to understanding aesthetic experience in relation to mindfulness as well as how these experiences complement one another. Although Dufrenne does not prioritise painting, the present paper will explore painting in particular due to its embodied, gestural nature, which utilises the notion of style, reflecting the artist’s mode of being-in- the-world. Dufrenne’s ideas allow both mindfulness and painting to be understood in more comprehensive terms than that of their meanings considered individually.
Hurricane Model Development at GFDL: A Collaborative Success Story from a Historical Perspective
Authors: Bender Morris A. , Marchok Timothy , Tuleya Robert E. , Ginis Isaac , Tallapragada Vijay , Lord Stephen J. 
Published: May 2019

AbstractThe hurricane project at the National Oceanic and Atmospheric Administration (NOAA) Geophysical Fluid Dynamics Laboratory (GFDL) was established in 1970. By the mid-1970s pioneering research had led to the development of a new hurricane model. As the reputation of the model grew, GFDL was approached in 1986 by the director of the National Meteorological Center about establishing a collaboration between the two federal organizations to transition the model into an operational modeling system. After a multiyear effort by GFDL scientists to develop a system that could support rigorous requirements of operations, and multiyear testing had demonstrated its superior performance compared to existing guidance products, operational implementation was made in 1995. Through collaboration between GFDL and the U.S. Navy, the model was also made operational at Fleet Numerical Meteorology and Oceanography Center in 1996. GFDL scientists continued to support and improve the model during the next two decades by collaborating with other scientists at GFDL, the National Centers for Environmental Prediction (NCEP) Environmental Modeling Center (EMC),1 the National Hurricane Center, the U.S. Navy, the University of Rhode Island (URI), Old Dominion University, and the NOAA Hurricane Research Division. Scientists at GFDL, URI, and EMC collaborated to transfer key components of the GFDL model to the NWS new Hurricane Weather Research and Forecasting Model (HWRF) that became operational in 2007. The purpose of the article is to highlight the critical role of these collaborations. It is hoped that the experiences of the authors will serve as an example of how such collaboration can benefit the nation with improved weather guidance products.
Quantification of Voice Type Components Present in Human Phonation Using a Modified Diffusive Chaos Technique
Authors: Liu Boquan , Polce Evan , Raj Hayley , Jiang Jack 
Published: May 2019

Purpose: Signal typing has been used to categorize healthy and disordered voices; however, human voices are likely comprised of differing proportions of periodic type 1 elements, type 2 elements that are periodic with modulations, aperiodic type 3 elements, and stochastic type 4 elements. A novel diffusive chaos method is presented to detect the distribution of voice types within a signal with the goal of providing an objective and clinically useful tool for evaluating the voice. It was predicted that continuous calculation of the diffusive chaos parameter throughout the voice sample would allow for construction of comprehensive voice type component profiles (VTCP). Methods: One hundred thirty-five voice samples of sustained /a/ vowels were randomly selected from the Disordered Voice Database Model 4337. All samples were classified according to the voice type paradigm using spectrogram analysis, yielding 34 type 1, 35 type 2, 42 type 3, and 24 type 4 voice samples. All samples were then analyzed using the diffusive chaos method, and VTCPs were generated to show the distribution of the 4 voice type components (VTC). Results: The proportions of VTC1 varied significantly between the majority of the traditional voice types ( P < .001). Three of the 4 VTCs of type 3 voices were significantly different from the VTCs of type 4 voices ( P < .001). These results were compared to calculations of spectrum convergence ratio, which did not vary significantly between voice types 1 and 2 or 2 and 3. Conclusion: The diffusive chaos method demonstrates proficiency in generating comprehensive VTCPs for disordered voices with varying severity. In contrast to acoustic parameters that provide a single measure of disorder, VTCPs can be used to detect subtler changes by observing variations in each VTC over time. This method also provides the advantage of quantifying stochastic noise components that are due to breathiness in the voice.
The association between lecithin–cholesterol acyltransferase activity and fatty liver index
Authors: Janac Jelena , Zeljkovic Aleksandra , Jelic-Ivanovic Zorana , Dimitrijevic-Sreckovic Vesna , Miljkovic Milica , Stefanovic Aleksandra , Munjas Jelena , Vekic Jelena , Kotur-Stevuljevic Jelena , Spasojević-Kalimanovska Vesna 
Published: May 2019

Background Non-alcoholic fatty liver disease is a frequent ailment with known complications, including those within the cardiovascular system. Associations between several indicators of high-density lipoprotein metabolism and function with clinical and laboratory parameters for the assessment of fatty liver index, a surrogate marker of non-alcoholic fatty liver disease, were evaluated. Methods The study comprised 130 patients classified according to fatty liver index values: fatty liver index < 30, fatty liver index 30–59 (the intermediate group) and fatty liver index ⩾ 60. Lecithin–cholesterol acyltransferase and cholesteryl ester transfer protein activities were determined. Paraoxonase 1 concentration and its activity, paraoxonase 3 concentration and high-density lipoprotein subclass distribution were assessed. Results Increased lecithin–cholesterol acyltransferase activity correlated with increased fatty liver index ( P < 0.001). Paraoxonase 3 concentration was lower in the fatty liver index ⩾ 60 group compared with the fatty liver index < 30 group ( P < 0.05). Cholesteryl ester transfer protein activity, paraoxonase 1 concentration and its activity did not significantly differ across the fatty liver index groups. The relative proportion of small-sized high-density lipoprotein 3 subclass was higher in the fatty liver index ⩾ 60 group compared with the other two fatty liver index groups ( P < 0.01). Lecithin–cholesterol acyltransferase activity positively associated with the fatty liver index ⩾ 60 group and remained significant after adjustment for other potential confounders. Only the triglyceride concentration remained significantly associated with lecithin–cholesterol acyltransferase activity when the parameters that constitute the fatty liver index equation were examined. Conclusions Higher lecithin–cholesterol acyltransferase activity is associated with elevated fatty liver index values. Significant independent association between triglycerides and lecithin–cholesterol acyltransferase activity might indicate a role of hypertriglyceridaemia in alterations of lecithin–cholesterol acyltransferase activity in individuals with elevated fatty liver index.
Investigating the provision of occupational therapy services: A case study
Authors: Carey Alicia , Cockburn Lynn , Langlois Sylvia 
Published: May 2019

Background. The World Health Organization has identified occupational therapists as integral human resources on health care teams, yet in many contexts, occupational therapy services are not adequately provided. One example is occupational therapy in mental health care in Saskatchewan. Purpose. This study aimed to uncover what is known about the case of occupational therapy in the context of mental health services in Saskatchewan. Method. An instrumental case study design was employed, applying a critical interpretive approach and thematic analysis to examine 40 publicly available documents. Findings. Three main themes (with subthemes) were identified: access (representation, funding, rural communities), awareness (comprehension, value, collaboration), and advocacy (leadership, education). Implications. This study illuminates how restricted access to, limited awareness of, and ineffective advocacy for occupational therapy impacts mental health services in Saskatchewan and provides a replicable process for other contexts where occupational therapy is underrepresented.
Investigation and treatment of pelvic vein reflux associated with varicose veins: Current views and practice of 100 UK vascular specialists
Authors: Campbell Bruce , Goodyear Stephen , Franklin Ian , Nyamekye Isaac , Poskitt Keith 
Published: May 2019

Objective Management of pelvic vein disorders possibly contributing to leg varicose veins remains variable and controversial. This survey investigated practice in the UK. Methods Email questionnaire to 328 members of the Vascular Society. Results One hundred and four (32%) questionnaires were returned. Of 100 respondents treating varicose veins, 9% do not recognise pelvic vein reflux and 11% never investigate or treat it. Indications for investigation include labial (94%) and buttock/upper thigh (70%) varicose veins: 46% use magnetic resonance venography and only 16% transvaginal duplex. Treatments used are coil embolization (89%), sclerotherapy via thigh veins (47%) and transcatheter sclerotherapy (26%). Thirty-four per cent treat only ovarian veins (not internal iliac tributaries). Follow-up is by clinical response (100%): only 14% use duplex. Only 5% treat >10 patients annually. Conclusions There is substantial variation in the management of pelvic vein reflux in the UK. There is need for further consensus and good clinical trial evidence to guide practice.
Treatment Choice in Adolescents With Cleft Lip and/or Palate: The Importance of Shared Decision-Making
Authors: Wogden Francesca , Norman Alyson , Dibben Louise 
Published: May 2019

Objective: Limited research has studied the involvement of children in medical decision-making. The aim of the study was to understand the involvement of adolescents with cleft lip and/or palate (CL/P) in decisions about elective surgeries and treatments. Design: Parents and professionals completed mixed-methods questionnaires about the degree to which children had been involved in choices about elective treatments. Data were analyzed using content analysis. Young people aged 12 to 25 years were asked to take part in semistructured interviews. The data were analyzed using inductive thematic analysis. Setting: Questionnaire data collection took place online, and interview data were collected via messenger or telephone-based interviews. Participants: The study employed 30 participants; 11 young people (3 male, 8 female), 17 parents (13 mothers, 4 fathers), and 5 professionals (2 surgeons, 2 speech and language therapists, and 1 pediatric dentist). Results: Five main themes were identified. These reflected participants feeling that with increasing age should come increased involvement in decision-making and that it was important for adolescents to “have a voice” during decision-making. Parents, peers, and health professionals were identified as influencing decisions. Most adolescents reported overall satisfaction with their involvement in decision-making but sometimes felt “left in the dark” by professionals or under pressure from parents. A desire to improve speech and/or appearance was as an area where adolescents wanted to be more involved in decision-making. Conclusions: Shared decision-making is an important factor for psychological well-being by promoting autonomy and self-esteem among adolescents with CL/P.
Work overload is related to increased risk of error during chemotherapy preparation
Authors: Carrez Laurent , Bouchoud Lucie , Fleury Sandrine , Combescure Christophe , Falaschi Ludivine , Sadeghipour Farshid , Bonnabry Pascal 
Published: May 2019

Purpose Chemotherapy preparation units face peaks in activity leading to high workloads and increased stress. The present study evaluated the impact of work overloads on the safety and accuracy of manual preparations. Method Simulating overwork, operators were asked to produce increasing numbers of syringes (8, 16, and 24), with markers (phenylephrine or lidocaine), within 1 h, in an isolator, under aseptic conditions. Results were analyzed using qualitative and quantitative criteria. Concentration deviations of < 5%, 5%–10%, 10%–30%, and >30% from the expected concentration were considered as accurate, weakly accurate, inaccurate, and wrong concentrations, respectively. Results Twenty-one pharmacy technicians and pharmacists carried out 63 preparation sessions (n = 1007 syringes). A statistically significant decrease in the manufacturing time for one syringe was observed when workload increased (p < 0.0001). Thirty-nine preparation errors were recorded: 30 wrong concentrations (deviation > 30%), 6 mislabeling, 2 wrong diluents, and 1 wrong drug. There was no statistically significant difference in the mean concentration accuracy of final preparations across the three workloads. The overall error rate increased with the number of preparations made in 1 h: 1.8% for 8 preparations, 2.7% for 16 preparations, and 5.4% for 24 preparations (p < 0.05). Conclusion Although pharmacy technicians and pharmacists were able to increase production speeds with no effect on mean concentration accuracy under stressful conditions, there were greater probability errors being made. These results should encourage actions to spread workloads out over the day to avoid peaks in activity.
Variation in femoral anteversion in patients requiring total hip replacement
Authors: Pierrepont Jim W , Marel Ed , Baré Jonathan V , Walter Leonard R , Stambouzou Catherine Z , Solomon Michael I , McMahon Stephen , Shimmin Andrew J 
Published: May 2019

Background: Optimal implant alignment is important for total hip replacement (THR) longevity. Femoral stem anteversion is influenced by the native femoral anteversion. Knowing a patient’s femoral morphology is therefore important when planning optimal THR alignment. We investigated variation in femoral anteversion across a patient population requiring THR. Methods: Preoperatively, native femoral neck anteversion was measured from 3-dimensional CT reconstructions in 1215 patients. Results: The median femoral anteversion was 14.4° (−27.1–54.5°, IQR 7.4–20.9°). There were significant gender differences (males 12.7°, females 16.0°; p < 0.0001). Femoral anteversion in males decreased significantly with increasing age. 14% of patients had extreme anteversion (<0° or >30°). Conclusions: This is the largest series investigating native femoral anteversion in a THR population. Patient variation was large and was similar to published findings of a non-THR population. Gender and age-related differences were observed. Native femoral anteversion is patient-specific and should be considered when planning THR.
Using body mass index ignores the intensive training of elite special force personnel
Authors: Tafeit Erwin , Cvirn Gerhard , Lamprecht Manfred , Hohensinn Markus , Moeller Reinhard , Hamlin Michael , Horejsi Renate 
Published: May 2019

Body mass index is a common and well-known measure in daily life. A body mass index higher than 25 is assumed to be an indicator for overweight and obesity and a high amount of total body fat. But body mass index overestimates body fat in subjects with high muscle mass and underestimates it in persons with a low lean body mass, especially in elderly and diseased persons. In the present study, we investigate the performance of the body mass index as a measure of body fatness and its ability to distinguish between well-trained and untrained subjects. Twenty-one well-trained male members of a police task force named “Cobra” and 38 non-active controls, matched by age, weight and height were participants of the study. The age range of these subjects was between 30 and 45 years. Subcutaneous adipose tissue thicknesses and body fat distributions were measured non-invasively by an optical device named the “Lipometer.” Statistics were performed with SPSS. We found that the body mass index did not show a difference between the two groups, whereas all Lipometer results were able to discriminate significantly between the trained and untrained subjects. Furthermore, the receiver operating characteristic curve analysis was calculated and all Lipometer measurements provided significant results up to a correct classification of all subjects of 86.4%, which was for the lateral thigh body site. In conclusion, the body mass index was not able to recognize the difference between trained and untrained participants, while body fat distribution measured with the Lipometer was able to distinguish more clearly the large body fat differences between these two groups. Impact statement Body mass index (BMI) is a common measure of body fatness but overestimates body fat in subjects with high muscle mass. We have developed previously a device named “Lipometer,” an alternative way to measure body fatness. We show herein that the Lipometer is able to distinguish more clearly (than the BMI) the large body fat differences between well-trained and untrained subjects. Thus, the Lipometer is superior to BMI with respect to body fat measurements.