bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligand Assisted Hydrogen Bonding: A Game‐Changer in Lead Passivation and Stability in Perovskite Solar Cells
Authors: Ahmed Rida , Rehman Sajidur , Chen Zhiliang , Ye Feihong , Ren Xingang 
Published: October 2024

AbstractLead halide perovskite solar cells (PSCs) have demonstrated power conversion efficiencies comparable to silicon‐based solar cells, yet their instability under environmental stressors, such as humidity, heat, and light, remains a significant barrier to commercialization. A primary cause of this instability is the uncoordinated lead ions (Pb2+), which accelerates the degradation of PSCs and pose environmental concerns due to potential lead leakage. Recently, the introduction of ligands into PSCs has shown promise in mitigating lead toxicity through effective passivation, primarily by forming hydrogen bonds (H‐bonds) between functional groups of the ligands and the perovskite structure. In this minireview, we explore the critical role of H‐bonds in stabilizing PSCs by enhancing the structural integrity of the perovskite layer and reducing lead leakage. Furthermore, we discuss the contribution of these ligands in defect passivation, hydrophobicity, self‐encapsulation, cross‐linking, and self‐healing mechanisms. These insights will highlight the multi‐functional capabilities of ligands in improving the long‐term stability and durability of PSCs, offering pathways to address current challenges in their commercialization.
Enantiomorphic Site‐Assisted Chain End Control Stereospecific Alternating Copolymerization of Chiral Cyclic Diesters
Authors: Xian Ji , Chen Hao , Yao Ge , Chen Fei , Chen Zhichun , Cao Hongzhang , Cao Luya , Pan Xiaobo , Tang Yu , Wu Jincai 
Published: October 2024

AbstractStereospecific alternating copolymerization of different chiral cyclic esters is one feasible approach to enrich the structural diversity of copolyesters and tailor their properties. However, dramatically different reactivities of different cyclic esters let a perfectly stereospecific alternating polymerization of these cyclic esters be a challenge, thus the catalyst is required to balance their reactivities. Herein, a remarkable enantiomorphic site effect on chain end control was discovered and successfully utilized to balance the reactivities of highly reactive S, S‐lactide (S, S‐LA) and low reactive R, R‐ethylglycolide (R, R‐EG)/R, R‐propylglycolide (R, R‐PG) during their heterospecific alternating copolymerization. The enantiomorphic site of R, R‐SalenAl complex can increase the relative reactivity of R, R‐EG/R, R‐PG and suppress that of S, S‐LA, then a perfectly alternating sequence of the copolymer of S, S‐LA and R, R‐EG/R, R‐PG can be achieved (Palt=0.96/0.91); inversely, using S, S‐SalenAl complex, the significant enantiomorphic site effect enlarges the reactivity difference of two monomers, the alternating level was just 0.70/0.68 even to 0.61. Poly(S, S‐LA‐alt‐R, R‐EG) with a high alternating regularity exhibits lower glass transition temperatures and a dramatically higher elongation at break (ϵB=449±51 % (Palt=0.96) vs ϵB=6±1% (Palt=0.70)).
Advanced functional polymer materials for biomedical applications
Authors: Elsayed Rokya , Teow Yeit Haan 
Published: October 2024

AbstractPolymer structures are essential in biomedical applications due to their biocompatibility, biodegradability, and ability to form intricate structures on micro‐ to nanometer scales. This review, emphasizing electrospinning and phase inversion techniques, examines the fabrication strategies and chemical design of polymer structures for biomedical use. Electrospinning, particularly needleless electrospinning, produces nanofibres with high porosity and flexibility and is widely applied in tissue engineering and drug delivery. Phase inversion, including thermal, nonsolvent‐, vapor‐ and evaporation‐induced phase separation, allows precise control over polymer properties but faces challenges in terms of cooling rates and solvent characteristics. Chemical design through doping, functionalization, cross‐linking and copolymerization enhances the biocompatibility, biodegradability and mechanical properties of polymers, facilitating advanced applications in drug delivery, tissue scaffolding and biosensors. Advanced functional polymers are revolutionizing biomedical fields, offering innovative solutions for therapeutic medicine delivery, disease detection, diagnostics, and regenerative medicine. Despite remarkable progress, challenges, such as scalability, cost‐effectiveness, and environmental impact, persist. This review underscores the transformative potential of advanced polymer materials in medical treatments and advocates for continuous research and interdisciplinary collaboration to overcome existing challenges and fully exploit the capabilities of these materials in improving patient care and medical outcomes. Future perspectives highlight enhancing precision control mechanisms, integrating phase inversion with other techniques and developing large‐scale production methods to advance the field further.
Tooth eruption status and bite force determine dental microwear texture gradients in albino rats (Rattus norvegicus forma domestica)
Authors: Winkler Daniela E. , Bernetière Isabelle , Böhmer Christine 
Published: October 2024

AbstractDental microwear texture analysis (DMTA) is widely applied for inferring diet in vertebrates. Besides diet and ingesta properties, factors like wear stage and bite force may affect microwear formation, potentially leading to tooth position‐specific microwear patterns. We investigated DMTA consistency along the upper cheek tooth row in young adult female rats at different growth stages, but with erupted adult dentitions. Bite forces for each molar (M) position were determined using muscle cross‐sectional areas and lever arm mechanics. Rats were categorized into three size classes based on increasing skull length. Maximum bite force increased with size, while across all size classes, M3 bite force was almost 1.4 times higher than M1 bite force. In size class 1, M1 and M2 showed higher values than M3 for DMTA complexity, height, and volume parameters, while in size class 3, M1 had the lowest values. Comparing the same tooth position between size classes revealed opposing trends: M1 and M2 showed, for most parameters, decreasing roughness and complexity from size class 1–3, while M3 displayed the opposite trend, with size class 1 showing lowest, and either size class 2 or 3 the highest roughness and complexity values. This suggests that as rats age and M3 fully occludes, it becomes more utilized during mastication. DMTA, being a short‐term diet proxy, is influenced by eruption and occlusion status changes. Our findings emphasize the importance of bite force and ontogenetic stage when interpreting microwear patterns and advise to select teeth in full occlusion for diet reconstruction.
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential
Authors: Wiraswati Hesti Lina , Ma'ruf Ilma Fauziah , Sharifi‐Rad Javad , Calina Daniela 
Published: October 2024

AbstractAnticancer drug discovery needs serious attention to overcome the high mortality rate caused by cancer. There are still many obstacles to treating this disease, such as the high cost of chemotherapeutic drugs, the resulting side effects from the drug, and the occurrence of multidrug resistance. Herbaceous plants are a reservoir of natural compounds that can be anticancer drugs with novel mechanisms of action. Piperine, a bioactive compound derived from Piper species, is gaining attention due to its unique dual role in directly inhibiting tumor growth and enhancing the bioavailability of chemotherapeutic drugs. Unlike conventional treatments, Piperine exhibits a novel mechanism of action by modulating multiple signaling pathways, including apoptosis and autophagy, with low toxicity. Additionally, Piperine acts as a bioenhancer by improving the absorption and effectiveness of other anticancer agents, reducing the required dosage, and minimizing side effects. Therefore, this review aims to visualize a summary of Piperine sources, phytochemistry, chemical structure–anticancer activity relationship, anticancer activities of semi‐synthetic derivatives, pharmacokinetic and bioavailability, in vitro and in vivo preclinical studies, mechanism of antitumor action, human clinical trials, toxicity, side effects, and safety of Piperine. References were collected from the Pubmed/MedLine database (https://pubmed.ncbi.nlm.nih.gov/) with the following keywords: “Piperine anticancer,” “Piperine derivatives,” “Piperine antitumor mechanism” and “Piperine pharmacokinetic and bioavailability,” after filter process by inclusion and exclusion criteria, 101 were selected from 444 articles. From 2013 to 2023, there were numerous studies regarding preclinical studies of Piperine of various cell lines, including breast cancer, prostate cancer, lung cancer, melanoma, cervical cancer, gastric cancer, osteosarcoma, colon cancer, hepatocellular carcinoma, ovarian cancer, leukemia, colorectal cancer, and hypopharyngeal carcinoma. In vivo, the anticancer study has also been conducted on some animal models, such as Ehrlich carcinoma‐bearing mice, Ehrlich ascites carcinoma cells‐bearing Balbc mice, hepatocellular carcinoma‐bearing Wistar rat, A375SM cells‐bearing mice, A375P cells‐bearing mice, SNU‐16 cells‐bearing BalbC mice, and HGC‐27‐bearing baby mice. Treatment with this compound leads to cell proliferation inhibition and induction of apoptosis. Piperine has been used for clinical trials of diseases, but no cancer patient report exists. Various semi‐synthetic derivatives of Piperine show efficacy as an anticancer drug across multiple cell lines. Piperine shows promise for use in cancer clinical trials, either as a standalone treatment or as a bioenhancer. Its bioenhancer properties may enhance the efficacy of existing chemotherapeutic agents, providing a valuable foundation for developing new anticancer therapies.
Defining Golden Batches in Biomanufacturing Processes From Internal Metabolic Activity to Detect Process Changes That May Affect Product Quality
Authors: Bush Xin , Fratz‐Berilla Erica J. , Kohnhorst Casey L. , King Roberta , Agarabi Cyrus , Powers David N. , Trunfio Nicholas 
Published: October 2024

ABSTRACTCellular metabolism plays a role in the observed variability of a drug substance's Critical Quality Attributes (CQAs) made by biomanufacturing processes. Therefore, here we describe a new approach for monitoring biomanufacturing processes that measures a set of metabolic reaction rates (named Critical Metabolic Parameters (CMP) in addition to the macroscopic process conditions currently being used as Critical Process Parameters (CPP) for biomanufacturing. Constraint‐based systems biology models like Flux Balance Analysis (FBA) are used to estimate metabolic reaction rates, and metabolic rates are used as inputs for multivariate Batch Evolution Models (BEM). Metabolic activity was reproducible among batches and could be monitored to detect a deliberately induced macroscopic process shift (i.e., temperature change). The CMP approach has the potential to enable “golden batches” in biomanufacturing processes to be defined from the internal metabolic activity and to aid in detecting process changes that may impact the quality of the product. Overall, the data suggested that monitoring of metabolic activity has promise for biomanufacturing process control.
The Effectiveness of Cognitive Behavioral Therapy on Depression and Anxiety Symptoms in Breast Cancer Patients and Survivors: A Systematic Review of Interventional Studies
Authors: Azizi Marzieh , Heshmatnia Fatemeh , Milani Hamed , Shahhosseini Zohreh , Marvdashti Leila Monjazeb , Moghadam Zahra Behboodi 
Published: October 2024

ABSTRACTIntroductionBreast cancer (BC) is the most common type of cancer and the second cause of cancer‐related death among women. Psychological treatments such as cognitive behavioral therapy (CBT) have been used as an effective method in the treatment of depression and anxiety in BC patients, and their effectiveness has been approved in various studies.ObjectiveThe present study aimed to systematically investigate the effectiveness of CBT on depression and anxiety symptoms in BC patients and survivors.MethodsElectronic databases such as PubMed, Scopus, Web of Science [WOS], ScienceDirect, Cochrane Library, and Google Scholar were systematically searched from “October 2023” to “February 2024.” The quality of the included studies was evaluated using the Critical Appraisal Skills Programme (CASP). In this study, the randomized controlled trials and quasi‐experimental studies that assessed the effectiveness of CBT, cognitive behavioral group therapy (CBGT), and the combination of CBT with other psychological studies on depression and anxiety of BC patients and survivors were reviewed.ResultsOut of the 16 included studies, six used CBT, and six used CBGT. In the other four studies, a combination of CBT with other psychological interventions was implemented as an interventional program. Among 16 included studies, 14 studies showed that CBT, CBGT, and a combination of CBT with other psychological interventions significantly decreased the anxiety and depression scores among BC patients and survivors (p < 0.05), and only in two studies, no significant effect was observed.ConclusionAs most included studies showed the effectiveness of CBT in decreasing the depression and anxiety scores among BC patients and survivors, this study strongly suggests CBT as an effective non‐pharmacological method for the treatment of psychiatric disorders of BC patients during cancer treatments and also for BC survivors.
Enhancing educational efficiency: Generative AI chatbots and DevOps in Education 4.0
Authors: Mekić Edis S. , Jovanović Mihailo N. , Kuk Kristijan V. , Prlinčević Bojan P. , Savić Ana M. 
Published: October 2024

AbstractThe emergence of new technologies has developed a new industrial need for engineering graduate students. This modern industry needs a modern educational framework to support further development. This research revolves around developing the learning methodological approach for university courses that aligns with Education 4.0 and can fulfill the essential knowledge requirements for future engineers in Industry 4.0. We used a constructive approach as a baseline methodology already proven in the field of engineering education. On the other hand, we modified this approach by implementing Industry 4.0 standards, such as Agile methodology, DevOps tools, and Artificial intelligence chatbots. In this way, we managed to establish one more step in the digital transformation of education as one of the paramount cornerstones of Industry 4.0. As a result, during the course, Agile methodology and DevOps tools created a learning environment very similar to the real software development environment in companies. The efficiency of the delivery of the learning material also increased by implementation and integration of AI chatbots. This was tracked by the number of projects developed during course implementation. The study showed that in the field of education, the implementation of novel approaches developed in the industry to increase efficiency can be implemented in the educational environment. It also showed that the implementation of those methodologies does not hinder but improves the efficiency of the educational cycle.
Oxidative Stress Associated With Increased Reactive Nitrogen Species Generation in the Liver and Kidney Caused by a Major Metabolite Accumulating in Tyrosinemia Type 1
Authors: Bender Julia Gabrieli , Ribeiro Rafael Teixeira , Zemniaçak Ângela Beatris , Palavro Rafael , Marschner Rafael Aguiar , Wajner Simone Magagnin , Castro Ediandra Tissot , Leipnitz Guilhian , Wajner Moacir , Amaral Alexandre Umpierrez 
Published: October 2024

ABSTRACTTyrosinemia type 1 (TT1) is caused by fumarylacetoacetate hydrolase activity deficiency, resulting in tissue accumulation of upstream metabolites, including succinylacetone (SA), the pathognomonic compound of this disease. Since the pathogenesis of liver and kidney damage observed in the TT1‐affected patients is practically unknown, this study assessed the effects of SA on important biomarkers of redox homeostasis in the liver and kidney of adolescent rats, as well as in hepatic (HepG2) and renal (HEK‐293) cultured cells. SA significantly increased nitrate and nitrite levels and decreased the concentrations of reduced glutathione (GSH) in the liver and kidney, indicating induction of reactive nitrogen species (RNS) generation and disruption of antioxidant defenses. Additionally, SA decreased the GSH levels and the activities of glutathione peroxidase, glutathione S‐transferase, glutathione reductase, and superoxide dismutase in hepatic and renal cells. Noteworthy, melatonin prevented the SA‐induced increase of nitrate and nitrite levels in the liver. Therefore, SA‐induced increase of RNS generation and impairment of enzymatic and nonenzymatic antioxidant defenses may contribute to hepatopathy and renal disease in TT1.
Percutaneous endovascular management of Angio‐Seal related vascular occlusion
Authors: Haberman Dan , Czulada Evan , Lupu Lior , Chitturi Kalyan R. , Chaturvedi Abhishek , Abusnina Waiel , Merdler Ilan , Reddy Pavan , Ben‐Dor Itsik , Satler Lowell F. , Waksman Ron , Bernardo Nelson L. 
Published: October 2024

AbstractBackgroundThe use of vascular closure devices (VCDs) to achieve quick and safe hemostasis after femoral arterial access is widely accepted. Major complications include bleeding and occlusion of the femoral artery due to device failure, which often necessitates vascular intervention. This manuscript details our peripheral percutaneous endovascular interventional (PEI) approach for the management of femoral artery occlusion resulting from Angio‐Seal (Terumo, Somerset, New Jersey, USA) VCD deployment.MethodsConsecutive patients who developed occlusive complications after Angio‐Seal deployment underwent PEI to overcome specific complications. Patients’ clinical and procedural characteristics, along with their short‐ and long‐term follow‐up data, were analyzed.ResultsThe study cohort included 40 patients who experienced Angio‐Seal occlusive complications between July 2013 and September 2023. The mean age of the patients was 74 ± 10 years and 55% were female. All the patients were treated with PEI, with an overall procedural success rate of 100%. The primary approach for PEI was directional atherectomy, which was used in 35 cases (88%), followed by balloon, while a cutting balloon was used in 5 patients (13%). Stenting served as the definitive therapy in only 7 patients (18%). No procedural complications or conversions to surgery were observed. During a median follow‐up of 244 (IQR = 100–707) days, none of the patients required re‐intervention related to Angio‐Seal occlusion and salvage intervention.ConclusionIn the management of Angi‐Seal VCD‐related femoral artery occlusion, the adjunctive use of directional atherectomy followed by balloon angioplasty was effective and safe, allowing re‐establishment of flow with excellent long‐term outcomes.
Unexpected multiple sclerosis‐like symptoms in a rheumatoid arthritis patient treated with Etanercept: A case report
Authors: Hosseinpour Ali , Haj Mohamad Ebrahim Ketabforoush Arsh , Daneshzad Elnaz , Babanezhad Gajouti Ali , Hajimollarabi Samaneh 
Published: October 2024

Key Clinical MassageAlthough tumor necrosis factor (TNF) inhibitors are used to prevent autoimmune disease, but they can cause adverse effects. Multiple sclerosis syndrome is one of the rare complications following treatment with TNF inhibitor. We reported a case of rheumatoid arthritis with unfavorable outcome post Etanerecept therapy.AbstractTumor necrosis factor (TNF) inhibitors are prescribed to treat various autoimmune diseases such as rheumatoid arthritis (RA). Etanercept, a human anti‐TNF monoclonal antibody, is a therapeutic option in autoimmune and inflammatory diseases. One of the rare adverse effects of Etanercept is developing central nervous system and peripheral nervous system demyelination however, there is controversy in the cause of it. In this case, we presented a 35‐year‐old woman with multiple sclerosis (MS)‐like symptoms due to taking Etanercept. She had a history of RA since the age of 18 years and was referred to the emergency department with signs and symptoms of para paresthesia, progressive paraparesis of both lower limbs, and urinary retention a year after Etanercept treatment. We discontinued the Etanercept and started Methylprednisolone and Rituximab. Rapid clinical improvement was noted and in the approximately 6‐month follow‐up, she did not exhibit any neurological worsening. So it is probable that the initiation of Etanercept triggered MS‐like syndrome in these patients and healthcare practitioners should take heed of this adverse effect.
Retrograde approach for recanalization in stumpless chronic total occlusion: A case report
Authors: Wang Dayu , Wei Ruibin , Zheng Junteng , Liu Zhen , Hou Jian , Li Jianhao 
Published: October 2024

Key Clinical MessageChronic total occlusive disease of the coronary arteries is the most challenging disease in the field of coronary intervention. When the anterograde approach is not feasible, the retrograde approach remains the only strategy.
Catalytic Ammonia Synthesis by Supported Molybdenum Nitride: Insight into the Support Effect
Authors: Sfeir Amanda , Teles Camila A. , Vezin Hervé , Marinova Maya , Dacquin Jean‐Philippe , Laassiri Said , Royer Sébastien 
Published: October 2024

AbstractThe influence of the support on the performance of Mo nitrides has been investigated in ammonia synthesis and decomposition. A series of Mo–N catalysts supported on different materials, namely SiO2 (commercial, SBA‐15), Al2O3, and CeO2, were prepared. The results indicated that, despite the high dispersion of Mo species in all catalysts, large disparities in the activity for ammonia synthesis exist. Initial rates of ∼1208, ∼481, and ∼372 µmol gactive phase−1 h−1 are obtained over 10‐Mo–N/SBA‐15, 10‐Mo–N/SiO2, and 10‐Mo–N/Al2O3 respectively. However, no catalytic activity was registered when Mo species were supported on CeO2. Furthermore, 10‐Mo–N/Al2O3 deactivated after few hours of reaction. The surface composition was studied by means of XPS to probe the origin of the catalytic activity differences, and the results indicated that a range of various oxidation states of Mo was detected depending on the support. The difference in catalytic behavior could not be solely explained by the differences in Mo–N species concentrations. In situ EPR analysis exhibited that the mechanism of MoO3 nitridation could differ depending on the support, leading to the formation of different Mo–N species. The effect of support was, however, not as severe in ammonia decomposition as it was the case of ammonia synthesis.
Focus on Physico‐Chemical Properties of Sulfoximines: Acidity, Basicity and Lipophilicity
Authors: Anselmi Elsa , Montigny Bénédicte , Lõkov Märt , Kesküla Carmen , Soosaar Jan Erik , Tshepelevitsh Sofja , Billard Thierry , Magnier Emmanuel , Leito Ivo 
Published: October 2024

AbstractDespite the numerous published syntheses and applications of sulfoximines, very few studies describe their physico‐chemical properties and in particular their acidic, basic and lipophilic or hydrophilic characters. We report for the first time the acidity values (pKa) of fluorinated sulfoximines in water and in acetonitrile, as well as the basicity (pKaH) measurements of fluorinated and non‐fluorinated sulfoximines in acetonitrile. The same sulfoximine library was also studied in terms of lipophilicity with measurement of the Hansch parameters of the sulfoximine moieties. Finally, these new data allowed us to optimize the N‐alkylation reaction of fluorinated sulfoximines.