bluuebunny/crossref_metadata_2025_split huggingface dataset:
<span>Bồi dưỡng tư duy h&agrave;m cho học sinh th&ocirc;ng qua dạy học chủ đề &ldquo;H&agrave;m số v&agrave; Đồ thị&rdquo; &ndash; To&aacute;n 8</span>
Authors: Ngô Tấn Thước 
Published: October 2024

Bài viết này phân tích làm rõ vai trò của tư duy hàm cùng những đặc trưng cơ bản trong dạy học toán, từ đó đề xuất một số biện pháp bồi dưỡng và phát triển tư duy hàm cho học sinh thông qua dạy học chủ đề Hàm số và Đồ thị - Toán 8. Trong mỗi biện pháp, chúng tôi đưa ra ví dụ áp dụng vào việc giảng dạy nội dung Hàm số và Đồ thị, nhằm giúp học sinh nâng cao năng lực giải toán đặc biệt là bài toán có yếu tố thực tiễn qua đó góp phần nâng cao chất lượng dạy học môn Toán ở trường phổ thông.
Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine
Authors: Bian Jiang-Yu , Feng Yu-Fang , He Wen-Ting , Zhang Tong 
Published: October 2024

BACKGROUND
Patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) have a low incidence rate, poor biological activity, suboptimal response to conventional treatments, and a poor prognosis. In the previous cohort study on mCRC conducted by our team, it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival (OS) of patients with colorectal cancer. Therefore, we further explored the survival benefits in the population with BRAF V600E mutant mCRC.
AIM
To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.
METHODS
A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022. The patients were divided into two cohorts.
RESULTS
A total of 34 cases were included, with 23 in Chinese-Western medicine cohort (cohort A) and 11 in Western medicine cohort (cohort B). The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B, with a statistically significant difference (P = 0.038, hazard ratio = 0.46). The 1-3-year survival rates were 95.65% (22/23), 39.13% (9/23), and 26.09% (6/23) in cohort A, and 63.64% (7/11), 18.18% (2/11), and 9.09% (1/11) in cohort B, respectively. Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon, liver metastasis, chemotherapy, and first-line treatment subgroups (P < 0.05).
CONCLUSION
Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer, with more pronounced benefits observed in patients with right colon involvement, liver metastasis, combined chemotherapy, and first-line treatment.
Extramedullary plasmacytoma with the uvula as first affected site: A case report
Authors: Yang Jing , Peng Hui , Tu Sheng-Ke , Li Min , Song Kui 
Published: October 2024

BACKGROUND
Extramedullary plasmacytoma (EMP) represents one of the rarer forms of plasma cell malignancies, capable of impacting a variety of tissues and organs throughout the body. The majority of EMP cases are predominantly found in the head and neck region, especially within the laryngopharynx, as well as in the gastrointestinal tract. While there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature, it is important to note that EMP specifically affecting the uvula is exceedingly uncommon. Furthermore, it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes, indicating a propensity for regional spread in these types of cancers. In this context, we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected site. This case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities, as early recognition and diagnosis can significantly influence patient management and treatment outcomes. In addition, a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation, ultimately aiming to enhance clinical understanding and improve patient care in similar situations.
CASE SUMMARY
A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass. A physical examination revealed a palpable left lymph node, and magnetic resonance imaging (MRI) of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the neck. The soft tissue mass was diagnosed as plasmacytoma by immunohistochemical analysis. Monoclonal immunoglobulins and bone marrow biopsy showed normal results. Therefore, we diagnosed that as EMP of the uvula. After four cycles of adjuvant chemotherapy dominated by bortezomib, MRI reexamination showed a significant reduction of the mass in the oropharynx and the cervical lymph nodes. Afterwards, the λ light chain returned to normal levels. There was no evidence of evolution to multiple myeloma.
CONCLUSION
We have reported a rare case of extramedullary plasmacytoma with the uvula as the first affected site and the relevant literature is reviewed to improve clinicians' awareness of such rare comorbidities.
Stand-Up Comedy as an Erotic Art: Reframing Stand-Up Comic Performance Through the Lens of Audre Lorde
Authors: Gogerty Megan 
Published: October 2024

ABSTRACT
Violent metaphors are common in the description of stand-up comedy. If a comedian is successful, she “kills”—vaudeville slang that hardened in the twentieth century into an aggressive, hierarchical ethos this article refers to as the dominance model that is problematic because it reproduces systems of oppression that disadvantage comedians of marginalized identities, especially women and LGBTQIA+ performers. While pervasive in the stand-up industry, the dominance model is not inherent to the art form itself but is rather a by-product of the white, heteropatriarchal culture in which stand-up was forged. A more inclusive model frames stand-up comedy as an erotic art as defined by Audre Lorde in “Uses of the Erotic.” Lorde argues that erotic knowledge is deeply felt in the body, joyful, and shared, a description that neatly encapsulates the experience of stand-up comedy for both performer and audience and offers a fresh, feminist approach to understanding stand-up comedy performance.
Implicações e riscos da gravidez ectópica para a saúde da mulher
Authors: Maia Patrícia Cristina de Véras Souza , Sa Marcos Vinicios Alves de , Mendes Jéssica Caroline Capela , Bueno Luana Mendonça Marques Ramos , Tavares Renato Augusto , Oliveira Bárbara Valinhas , Martins Isadora Queiroz , Biesdorf Anna Laura Carniel , Rocha Samara Atanielly 
Published: October 2024

OBJETIVO: Descrever as implicações e riscos da gravidez ectópica para a saúde da mulher. MÉTODO: A pesquisa é uma revisão integrativa, realizada com base na seguinte pergunta norteadora: Quais as implicações e riscos da gravidez ectópica para a saúde da mulher? Sendo utilizada a estratégia PICO, para a realização dessa pergunta, em que “p” população: Mulheres com gravidez ectópica, “I” interesse: Avaliação das implicações e riscos causados pela gravidez ectópica, e “C” e “O” contexto: Descrição das implicações e riscos causados pela gravidez ectópica. Utilizou-se a busca avançada por meio da Biblioteca Virtual em Saúde (BVS), cruzando os descritores por meio dos operadores booleanos “AND” e “OR”. RESULTADOS: Por meio da pesquisa avançada, obteve-se 186 artigos, dentre esses artigos 6 deles compõe esta pesquisa, o que resultou em categorias, que foram as seguintes: Gravidez ectópica (GE) e mortalidade materna; e fatores de riscos e diagnósticos da gravidez ectópica. CONCLUSÃO: Assim, diante do que foi abordado na pesquisa, observa-se que, a mulher com gravidez ectópica sofre diversos riscos, e o profissional de saúde deve estar ciente dessas implicações e atender a paciente de forma humanizada, acolhendo-a e sanando suas dúvidas sobre o diagnóstico e tratamento utilizado.
Visceral adiposity index, cardiorespiratory fitness, and fasting plasma glucose associations in adolescents
Authors: Musa Danladi Ibrahim , Okuneye Rafiu O , Momoh Joseph Ibrahim , Darma Musa Haladu , Onoja-Alexander Mary O , Mwangi Francis M 
Published: October 2024

BACKGROUND
The global rise in the prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is partly linked to the increasing rates of childhood obesity and physical inactivity.
AIM
To explore the independent relationships of visceral adiposity index (VAI) and cardiorespiratory fitness (CRF) with fasting plasma glucose (FPG) in adolescents.
METHODS
This descriptive cross-sectional study included 403 adolescents (202 boys and 201 girls) aged 11-19 years. Participants were evaluated for VAI, CRF, and FPG. Regression models, adjusted for age and maturity status, were used to assess the associations between VAI, CRF, and FPG.
RESULTS
The prevalence of T2DM risk was 15.3% (girls = 7.4%; boys = 7.9%). In boys, high VAI was positively associated with FPG (β = 0.190, P = 0.009), while low CRF was negatively associated with FPG (β = -0.206, P = 0.010). These associations persisted even after adjusting for CRF and VAI. However, no significant associations between VAI, CRF, and FPG were observed in girls (P > 0.05). Adolescents with high VAI and low fitness levels demonstrated poorer glycemic profiles.
CONCLUSION
Among boys, both VAI and CRF were independently associated with T2DM risk, with CRF showing a stronger association. These associations were not observed in girls. Promoting regular aerobic exercise and healthy diets may serve as essential public health promotion strategies in preventing and managing T2DM risk in adolescents.
Cost-utility and clinical outcome analysis of surgery or oral corticosteroids treatment in patients with chronic rhinosinusitis with nasal polyps
Authors: Zhang Jing , Sima Yutong , Shao Shan , Zheng Ming , Zhao Yan , Gao Fei , Wang Xiangdong , Zhang Luo 
Published: October 2024

Background:
Surgery and oral corticosteroids are recommended therapies for chronic rhinosinusitis with nasal polyps (CRSwNP) patients who are nonresponsive to intranasal corticosteroid treatment.

Objective:
This study aimed to compare the effectiveness of these 2 treatments in terms of improving sinus-related symptoms, enhancing quality of life, and economic costs and duration costs.

Methods:
This prospective study enrolled CRSwNP patients. All participants were instructed to complete the 22-item Sino-Nasal Outcome Test (SNOT-22), visual analog scale, and 36-item short-form (SF-36) questionnaire at baseline and 3 months after treatment. The nasal polyp score (NPS) was assessed via endoscopic examination. Additionally, patients were requested to maintain records of economic direct costs, other indirect costs, and duration costs throughout the 3-month period and to report them during each follow-up visit.

Results:
A total of 40 patients who underwent surgery or received oral corticosteroids were enrolled in this study. After 3 months of treatment, significant improvements were observed between baseline and 3 months after treatment in the NPS, total SNOT-22 score, and nasal congestion, runny nose, facial pain, olfactory function, and overall symptoms measured. Only headache and sleep order were improved in the surgery group. Both physical functioning and general health, as measured by the SF-36, improved after both treatments, and the role-physical, bodily pain, and social functioning domains of the SF-36 improved only in the surgery group. The changes in the NPS, nasal congestion, runny nose, olfactory function, and sleep disorders in the surgery group were greater than those in the oral corticosteroid group (P values = 0.0003, 0.0092, 0.0258, 0.0284, and 0.0164, respectively). Changes in the total SNOT-22 score and SF-36 subscores were not different between the 2 treatment groups. The direct economic costs and duration costs of surgical treatment were 4.5 times and 17.0 times higher, respectively, than those of oral corticosteroid treatment.

Conclusions:
Both surgical and oral corticosteroid treatments effectively improved clinical symptoms and quality of life in patients with CRSwNP. Patients who underwent surgery exhibited greater improvements in sinus-related symptoms. Nevertheless, oral corticosteroid treatment presented notable advantages in terms of economic cost and duration cost of disease-related care.
Symposium 5: Embedding Networked Learning in Greek Higher Education Institutions: Policy and Practice
Authors: Stamatis Demosthenes , Kargidis Theodoros 
Published: October 2024

The Operational Programme for Education and Initial Vocational Training (O.P. "Education") is a framework programme designed to aid Greece in meeting the challenges arising internationally due to the development of innovative technologies.(http://www.epeaek.gr). It is co-financed by the European Social Fund (ESF), the European Regional Development Fund (ERDF) and the Ministry of National Education. Having as a target to enhance the quality of education provided at all levels, the O.P. "Education" has funded a number of actions with the aim of raising the effectiveness and competitiveness of the existing system of Higher Education in Greece. Crucial among them was the action supporting the introduction and use of Information and Communication Technologies (ICTs) in the graduate and postgraduate study programmes (curricula) of Higher Education Institutions. This action is underway and is planned to finish by the end of 2008.
In this context most of the Greek Institutions are incorporating Networked Learning techniques (both synchronous and asynchronous) in their study programmes. The symposium has the goal of acting as a forum for the exchange of knowledge and experiences, gained in this process of introducing Networked Learning in Greek Higher Education Institutions, and to discuss policy and practice issues. The papers of the symposium focus on a number of such issues regarding organizational, pedagogical, and technological aspects of Networked Learning:

Sgouropoulou C., et. al. present a framework that has been established to support the combinatory use of distance learning techniques and multimedia-enhanced instructional content for the support of IT Curricula in Greek Technological Educational Institutes. They also present their evaluation results.
Vassilakis, Psaroudakis and Kalogiannakis analyze the use of an asynchronous education platform at Technological Educational Institute (TEI) of Crete, focusing on aspects regarding teacher-student relations.
Kabouridis G. presents an assessment of the influences and the consequences that networked learning techniques brought in the learning and working environment of the department Mechanical engineering, TEI of Patras and discuses the mutual impact of educational and technological issues.
Triantis D., Stavrakas I.,.et al., present a virtual laboratory environment which was developed in order to teach physics of semiconductors, in a blended learning approach.

This symposium was organised within the activities of the Project "Undergraduate Studies of the Technological Educational Institute of Thessaloniki/ Work Package 1" , funded in the context of the Priority Action Line 2: "Promotion and improvement of education and vocational training in the framework of lifelong learning" (EPEAEK, Action category 2.2.2.a.) of the Operational Program for Education and Initial Vocational Training.
Perancangan Sistem Informasi Pembayaran dan Pengelolaan Keuangan di ARC Group
Authors: Harahap Muhammad Jamil Ikhsan , Saputra Andre , Diansyah Risnal 
Published: October 2024

Sistem Informasi merupakan pengintegrasian data yang diubah dan dikelola menjadi informasi yang baik, jelas dan berguna bagi penggunanya. Perancangan sebuah sistem membutuhkan proses dan data yang akan di tentukan oleh perancangan. Unified Modeling Language (UML) merupakan sebuah standar bahasa yang banyak digunakan di dunia industri dalam pemodelan grafis yang bertujuan menganalisis, memvisualisasikan serta menjelaskan bagaimana cara kerja dari sebuah sistem. Penelitian ini berfokus pada perancangan sistem informasi pembayaran dan kelola keuangan pada ARC Group (PT. An cipta Wisata cabang Riau). Tujuan utamanya adalah untuk mempermudah pemesanan, pembayaran dan pengelolaan keuangan yang masih di lakukan secara manual. Perancangan sistem ini akan memudahkan pelanggan dalam memesan layanan tour serta melakukan pembayaran, dan untuk administrator akan memudahkan dalam mengelola keuangan pada ARC Group (PT. An cipta Wisata cabang Riau). Penelitian ini menggunakan metode sekuensial linear (waterfall) untuk pengembangan sistem, dengan menggunakan HTML, CSS, PHP, JavaScript, dan text editor Visual Studio Code untuk manajemen basis data serta mencangkup pengujian yang ketat untuk memastikan kualitas. Hasil yang didapatkan adalah sebuah sistem yang efektif dan mudah digunakan yang mendukung dalam operasional ARC Group (PT. An cipta Wisata cabang Riau).
Agitated tank biosorption of ibuprofen using corn cob
Authors: Vera Luisa M. , Astudillo Javier G. , Astudillo Sonia M. 
Published: October 2024

The presence of emerging contaminants, especially drugs for human and veterinary use in natural waters, due to their high degree of persistence and the fact that the treatments used in wastewater treatment plants (WWTP) are not efficient at removing them, has been the subject of study by the scientific community. In this work, the removal of ibuprofen from synthetic waters was studied working in an stirred tank using corn cob residues as a biosorbent. Aiming to achieve the highest drug removal rates, several parameters where studied such as: the concentration of biosorbent, the particle size of the biosorbent, the minimum contact time between both adsorbate and biosorbent to reach the equilibrium, the optimum pH and the temperature. The best conditions to remove ibuprofen (20 mg/L) from synthetic water were the use of 15 g/L of corn cobs with a particle size of 0.4191 mm stirring for one hour at pH 6.0. No matter the temperature, a removal rate of 50% was obtained after 10 minutes of contact,reaching an 89% at the equilibrium. A kinetic study showed that the pseudo-second-order kinetic model was the one that best reproduced the experimental data with a determination coefficient (R2) of 0.982, and for the equilibrium behavior, theFreundlich model was the best fit for the adsorption equilibrium data with a R2 of 0.972.
Queda tardia do coto umbilical – relato de caso
Authors: Souza Ronne , Costa Felipe de Souza , Mendonça Douglas Gonçalves , Inácio Netto Rafael , Firmino Silvana Glicéria , Souza Kleysson Gonçalves de , Sá Hérica Barbara Rosa , Duarte Poliana Rodrigues Alves 
Published: October 2024

Introdução: o cordão umbilical é um anexo que assegura a sobrevivência e o desenvolvimento fetal intraútero. Após o nascimento é cortado e é chamado de coto umbilical. Fisiologicamente, ocorre a desidratação, mumificação e o desprendimento espontâneo cerca de sete dias após o nascimento. Cuidados de higiene são fundamentais para garantir a evolução natural à queda do coto e prevenir riscos de complicações. Entretanto, em alguns casos, mesmo com a adequada técnica de cuidados, pode-se perceber esse período prolongado. Descrição: um caso de queda tardia do coto umbilical, numa criança do sexo feminino, que ocorreu no 61º dia de vida, sem complicações associadas. Discussão: O MS do Brasil e a OMS, estabelecem a necessidade de higienização do coto com álcool etílico 70% ou solução de clorexidina alcóolica a 0,5% após o banho e à troca de fraldas, sem cobri-lo e deixando-o seco. Apesar das recomendações, ainda é evidente a realização de práticas que corroboram o desencadeamento de um processo infeccioso, atraso na queda do coto umbilical ou até mesmo antecipação de modo nocivo. Ademais, outros fatores como o peso ao nascer, a administração de antibióticos intraparto podem favorecer o desprendimento tardio, mesmo com o cuidado adequado e na ausência de sinais de complicações. Conclusão: o caso relatado aponta a importância do desenvolvimento de estudos baseado em evidências relacionadas aos cuidados com o coto umbilical, a fim de evitar a ocorrência de agravos, aprimorar o cuidado e evitar o uso de produtos ou práticas fitoterápicas sem benefícios cientificamente comprovados e potencialmente prejudiciais.
PENGUATAN TRANSFORMASI DIGITAL MEDIA MASSA DALAM RANGKA METAHANAN NASIONAL
Authors: Winarko Heru , Avianto Lucky 
Published: October 2024

Saat ini kemajuan global telah mencapai fase Revolusi Industri 4.0 dan sedang memasuki masa depan Society 5.0 dimana teknologi digital semakin memiliki peran yang penting di berbagai aspek kehidupan manusia telah mendorong pemanfaatan internet secara global, hal ini bersifat borderless(tidak terikat ruang dan waktu) yang melahirkan dirupsi teknologi digital dalam suatu sistem, termasuk bidang media massa, sehingga untuk dapat bertahan, media massa konvensional harus melakukan perubahan dan konvergensi digital dalam bentuk manfaat, tantangan , bahkan dapat juga dalam bentuk risiko ancaman kepada individu, masyarakat, lembaga dan juga kepada negara. Desain penelitian ini adalah penelitian deskriptif kualitatif untuk menggambarkan kondisi media massa dengan tujuan untuk menemukan a) kondisi media massa dalam menghadapi platform digital global saat ini, b) permasalahan dalam menghadapi transformasi global, dan c) penguatan transformasi digital media massa dalam rangka ketahanan nasional,. Analisis data dilakukan secara. Ratifikasi, menghasilkan simpulan bahwa penguatan digital media massa urgen antara lain meliputi program aspek percepatan penyediaan infrastruktur Teknologi Informasi dan Komunikasi (TIK), percepatan transformasi digital dalam tiga kerangka nasional yaitu, industri, pemerintahan dan masyarakat, peningkatan kualitas pengelolaan komunikasi publik. Dengan memperhatikan perkembangan media massa di Indonesia dari era ke era menunjukkan naik turun fungsi dan peran media massa pada kehidupan bernegara. Adapun perubahan materi hukum media massa yang pernah diterapkan, yaitu memberikan kewenangan penuh kepada pemerintah melakukan sensor preventif, memeberi kewenangan untuk menutup sebuah media massa dan memberi kewenangan pihak yang mengeluarkan surat izin untuk mencabut izinnya, sehingga perlu dilakukan penguatan transformasi digital media massa melalui Starategi Regulasi, Staretegi Kesiapan infrastruktur, Startegi Keamanan Siber dan Staregi kesiapan sumber daya manusia.
Evaluating a Polyhouse Pond-based Aquaculture Production System for Cultivating Neolissochilus hexagonolepis (Chocolate Mahseer) in the Agro-climatic Conditions of Meghalaya, Northeast India
Authors: Debnath Chandan , S. Gojendro Singh  , Prasanta Mahanta  , Tasso Tayung  
Published: October 2024

This study evaluated a polyhouse pond aquaculture system (PPAS, 200m2) for cultivating chocolate mahseer (Neolissochilus hexagonolepis) under Meghalaya’s agro-climatic conditions. Over two years, chocolate mahseer growth, survival, and biomass production in PPAS were compared against a conventional open pond aquaculture system (OPAS, 200m2). PPAS demonstrated substantial advantages, with fish exhibiting 34.6% higher final weight (112.24 ± 7.10g vs 83.38 ± 9.91g), 34.8% greater daily weight gain (0.31 ± 0.02 g/day vs 0.23 ± 0.03 g/day), 7.8% higher specific growth rate (1.10 ± 0.04 %/day vs 1.02 ± 0.08 %/day), and 16.1% better survival rate (83.85 ± 5.02% vs 72.20 ± 6.85%) compared to OPAS. Consequently, PPAS total fish biomass (941.97 ± 91.20 kg/ha) was 56.5% greater than OPAS (601.84 ± 90.60 kg/ha). PPAS maintained an average 2.4°C higher water temperature, with a 3.2°C difference during winter. Despite higher initial investment (₹ 85,000 vs ₹ 50,000) PPAS net profit (₹ 6,872) was substantially higher than OPAS (₹ 2,432) due to increased biomass. This innovative system mitigates environmental constraints, meriting further research for enhancing economic viability and long-term sustainability in adverse climatic regions.