bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the performance of benign and malignant breast lesion classification with bilateral TIC differentiation and other effective features in DCE‐MRI
Authors: Li Hong , Sun Hang , Liu Siqi , Zhang Wei , Arukalam Felicity Mmaezi , Ma He , Qian Wei 
Published: January 2019

BackgroundDynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) is increasingly being used to detect and diagnose breast cancer. However, the effective methods based on quantitative feature analysis need to be explored.PurposeTo investigate a new approach for improving the performance of benign and malignant breast lesion classification by combining bilateral time–intensity curve (TIC) differentiation features with other effective features.Study TypeRetrospective.PopulationIn all, 112 DCE‐MRI biopsy‐proven breast examinations (45 malignant tumors and 67 benign tumors).Field Strength/Sequence3 T MR with a breast coil. Precontrast images were acquired before contrast administration. Subsequently, postcontrast images were acquired approximately every minute directly following administration of the contrast agent (gadopentetate dimeglumine). The postcontrast images contain eight sequences in total. Each sequence contains 78 slices.Assessment: Accuracy, sensitivity, specificity, and the area under the curve (AUC) of the classification was calculated and compared with the published result.Statistical TestsFive‐fold crossvalidation was used.ResultsAreas under the receiver operating characteristic (ROC) curve (AUCs) of 0.8461, 0.7914, 0.8514, and 0.9058 were achieved using conventional features, unilateral TIC features, bilateral TIC differentiation features, and all the selected features, respectively. In terms of accuracy, the use of only unilateral TIC features or conventional features achieved an accuracy of 0.7321 or 0.8482 (sensitivity of 0.7556 or 0.7111 and specificity of 0.7164 or 0.9403). However, the accuracy increased to 0.9196 (sensitivity of 0.8889 and specificity of 0.9403) when bilateral TIC differentiation features were included.Data ConclusionBilateral differentiation TIC features can serve as a stronger indicator in differentiating benign and malignant breast lesions than the unilateral TIC features computed from one side of the breast only and some conventional features that are commonly used in MR image analysis.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;50:465–473.
Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?
Authors: Tavelli Lorenzo , Barootchi Shayan , Greenwell Henry , Wang Hom‐Lay 
Published: January 2019

AbstractSoft tissue augmentation procedures are becoming more popular these days. Different soft tissue graft harvesting approaches have been proposed. Nonetheless, the location of the donor site (whether anterior‐, lateral‐, superficial‐, deep‐palate or the maxillary tuberosity) can affect the graft shape and its composition. Soft tissue grafts from the maxillary tuberosity are rich in connective tissue fibers, with minimal presence of fatty or glandular components. Clinical, histological, and molecular evidence shows that a soft tissue graft obtained from the maxillary tuberosity has unique properties. In addition, harvesting from this area presents minimal risk for intra‐ or postoperative complications, leading to reduced patient morbidity. The aim of this commentary is to discuss the advantages and disadvantages of harvesting a soft tissue graft from the tuberosity and to compare it with the traditional palatal graft, while highlighting functional, esthetic, and patient‐related outcomes.
Ultrasensitive separation of methylprednisolone acetate using a photoresponsive molecularly imprinted polymer incorporated polyester dendrimer based on magnetic nanoparticles
Authors: Baimani Nasim , Aberoomand Azar Parviz , Waqif Husain Syed , Ahmad Panahi Homayon , Mehramizi Ali 
Published: January 2019

AbstractWe developed an approach for the use of polyester dendrimer during the imprinting process to raise the number of recognized sites in the polymer matrix and improve its identification ability. Photoresponsive molecularly imprinted polymers were synthesized on modified magnetic nanoparticles involving polyester dendrimer which uses the reactivity between allyl glycidyl ether and acrylic acid for the high‐yielding assembly by surface polymerization. The photoresponsive molecularly imprinted polymers were constructed using methylprednisoloneacetate as the template, water‐soluble azobenzene involving 5‐[(4, 3‐(methacryloyloxy) phenyl) diazenyl] dihydroxy aniline as the novel functional monomer, and ethylene glycol dimethacrylate as the cross‐linker. Through the evaluation of a series of features of spectroscopic and nano‐structural, this sorbent showed excellent selective adsorption, recognition for the template, and provided a highly selective and sensitive strategy for determining the methylprednisoloneacetate in real and pharmaceutical samples. In addition, this sorbent according to good photo‐responsive features and specific affinity to methylprednisoloneacetate with high recognition ability, represented higher binding capacity, a more extensive specific area, and faster mass transfer rate than its corresponding surface molecularly imprinted polymer.
Identification of a pathogenic mutation in ATP2A1 via in silico analysis of exome data for cryptic aberrant splice sites
Authors: Bruels Christine C. , Li Chengcheng , Mendoza Tonatiuh , Khan Jamillah , Reddy Hemakumar M. , Estrella Elicia A. , Ghosh Partha S. , Darras Basil T. , Lidov Hart G. W. , Pacak Christina A. , Kunkel Louis M. , Modave François , Draper Isabelle , Kang Peter B. 
Published: January 2019

AbstractBackgroundPathogenic mutations causing aberrant splicing are often difficult to detect. Standard variant analysis of next‐generation sequence (NGS) data focuses on canonical splice sites. Noncanonical splice sites are more difficult to ascertain.MethodsWe developed a bioinformatics pipeline that screens existing NGS data for potentially aberrant novel essential splice sites (PANESS) and performed a pilot study on a family with a myotonic disorder. Further analyses were performed via qRT‐PCR, immunoblotting, and immunohistochemistry. RNAi knockdown studies were performed in Drosophila to model the gene deficiency.ResultsThe PANESS pipeline identified a homozygous ATP2A1 variant (NC_000016.9:g.28905928G>A; NM_004320.4:c.1287G>A:p.(Glu429=)) that was predicted to cause the omission of exon 11. Aberrant splicing of ATP2A1 was confirmed via qRT‐PCR, and abnormal expression of the protein product sarcoplasmic/endoplasmic reticulum Ca++ ATPase 1 (SERCA1) was demonstrated in quadriceps femoris tissue from the proband. Ubiquitous knockdown of SERCA led to lethality in Drosophila, as did knockdown targeting differentiating or fusing myoblasts.ConclusionsThis study confirms the potential of novel in silico algorithms to detect cryptic mutations in existing NGS data; expands the phenotypic spectrum of ATP2A1 mutations beyond classic Brody myopathy; and suggests that genetic testing of ATP2A1 should be considered in patients with clinical myotonia.
Compact dual‐band antenna with slotted ground for implantable applications
Authors: Luo Lingzhi , Hu Bing , Wu Jiahui , Yan Tianwen , Xu Li‐Jie 
Published: January 2019

AbstractIn this article, a miniaturized circular planar inverted‐F antenna (PIFA) is proposed for biomedical applications, operating in Medical Device Radiocommunications Service (MedRadio; 401‐406 MHz) band and Industrial Scientific and Medical (ISM; 2.4‐2.4835 GHz) band. It consists of a U‐shaped patch on top layer, a circular ground on bottom layer, and a shorting pin connecting two layers. By adding two sets of open‐end slots in the ground, dual‐band performance of the proposed antenna is achieved with compact size. Measurement result shows that a wide bandwidth of 41%, ranging from 345 to 510 MHz, can be achieved in MedRadio band, and a wide bandwidth of 27.8%, ranging from 1.92 to 2.60 GHz, can be achieved in ISM band.
Determination of physical location of fiber Bragg gratings using traversal heat‐induced phase shift
Authors: Rodzi Noor Shafikah Md , Mokhtar Mohd Ridzuan , Yusoff Zulfadzli 
Published: January 2019

AbstractIn certain application, the exact location of the grating structure of fiber Bragg grating (FBG) is crucial for properly packaging, altering or exploiting the device. This article proposes a simple way to determine the location of FBG by applying heat induced phase shift. A traversing thin heating element is continuously scanned across the FBG while the local optical spectral profile is analyzed. The experiments are performed on an apodised uniform FBG and a chirped FBG. The results show that the symmetry of the local spectral profiles and prominence of the phase‐induced spectral dip can be used to determine the structure center and exact physical location of the apodised FBG. Meanwhile, the location of the linearly chirped FBG can be determined by simply observing the wavelength of the spectral dip.
Design and realization of multilayered cylindrical dielectric lens antenna using 3D printing technology
Authors: Mahouti Peyman , Belen Mehmet A. , Güneş Filiz , Yurt Reyhan 
Published: January 2019

AbstractHerein, design and realization of a novel, low cost, small size, high gain, 3D printed multilayered cylindrical dielectric lens antenna (MLCDLA) is presented at 10 GHz. In the first stage, MLCDLA is designed suitable the 3D printed technology in CST 3D EM simulation environment. Then gain, return loss, and radiation pattern of the design are investigated in the X‐band frequencies in the same 3D simulated environment. In the second stage, the designed lens is fabricated by the 3D printed technology in dimensions of 30 × 30 × 52.5 mm3 using acrylonitrile butadiene styrene, with εr = 2.5. In the final stage, performance characteristics of the proposed LCDLA are measured using 10 GHz rectangular waveguide as feeding unit and are compared with the simulated results and counterpart designs in literature. The prototyped MLCDLA is achieved 14 dBi measured gain at 10 GHz. It can be concluded that the proposed 3D printing method not only enables a high performance MLCDLA design but also provides its fast, low cost, and effective prototyping process which can be used for other microwave devices.
Efficacy of an unguided internet‐based self‐help intervention for social anxiety disorder in university students: A randomized controlled trial
Authors: Kählke Fanny , Berger Thomas , Schulz Ava , Baumeister Harald , Berking Matthias , Auerbach Randy P. , Bruffaerts Ronny , Cuijpers Pim , Kessler Ronald C. , Ebert David Daniel 
Published: January 2019

AbstractObjectivesInternet‐ and mobile‐based interventions (IMIs) offer the opportunity to deliver mental health treatments on a large scale. This randomized controlled trial evaluated the efficacy of an unguided IMI (StudiCare SAD) for university students with social anxiety disorder (SAD).MethodsUniversity students (N = 200) diagnosed with SAD were randomly assigned to an IMI or a waitlist control group (WLC) with full access to treatment as usual. StudiCare SAD consists of nine sessions. The primary outcome was SAD symptoms at posttreatment (10 weeks), assessed via the Social Phobia Scale (SPS) and the Social Interaction Anxiety Scale (SIAS). Secondary outcomes included depression, quality of life, fear of positive evaluation, general psychopathology, and interpersonal problems.ResultsResults indicated moderate to large effect sizes in favor of StudiCare SAD compared with WLC for SAD at posttest for the primary outcomes (SPS: d = 0.76; SIAS: d = 0.55, p < 0.001). Effects on all secondary outcomes were significant and in favor of the intervention group.ConclusionStudiCare SAD has proven effective in reducing SAD symptoms in university students. Providing IMIs may be a promising way to reach university students with SAD at an early stage with an effective treatment.
The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma
Authors: Weintraub Naomi , Reshef Nurit , Pe'er Jacob , Frenkel Shahar , Rot Ido , Shoshani Naomi , Weintraub Michael 
Published: January 2019

AbstractBackgroundMonocular vision has been found to have a negative effect on children's motion processing and motor functions. Yet, knowledge of motor function of survivors of retinoblastoma (RB) with monocular vision (due to enucleation, for example) is limited. This study examined motor function and its relationship to visual‐related and health‐related quality of life (HRQOL) in survivors of RB with monocular vision.ProcedureParents of 27 survivors of RB, who underwent an enucleation of one eye resulting in monocular vision, and of 21 typically developing children between the ages of 6 and 12, were administered questionnaires relating to their children's motor function (DCDQ), as well as vision‐related function (CVFQ) and HRQOL (PedsQL).ResultsOf the 27 survivors of RB, 7 (25.6%) were found to have difficulties in motor functions, compared with 1 (4.8%) child in the control group. The difficulties were faced mainly in daily function requiring control during movement, including jumping, running, and ball playing. Additionally, significant correlations were found between motor functions and children's QOL. Finally, survivors of RB with monocular vision were found to have lower QOL, specifically physical‐ and school‐related QOL.ConclusionSurvivors of RB who have monocular vision have a higher rate of decreased motor function and lower QOL. These results point to a need for ongoing assessment of survivors of RB to allow timely detection of motor deficits and to institute appropriate therapeutic interventions.
Laser Implantation: An Innovative Technique for Surface Texturing
Authors: Spranger Felix , Hilgenberg Kai 
Published: January 2019

AbstractTextured surfaces are used in a wide range of engineering applications like aeronautics, automotive industry, or manufacturing technology. Especially the use of micro‐elevated surface features has been shown to be very beneficial to adjust frictional conditions. However, protruding microfeatures are susceptible to wear and a reliable texturing process is difficult to achieve. By introducing the laser implantation technique, this may change.
Brilliant High Performance – Flexible Configuration
Authors: Molitor Thomas 
Published: January 2019

AbstractToday, high‐power diode lasers already cover a wide range of applications. Besides the continuous power improvements, the key to success is a high variability in terms of beam quality: Large‐scale heat treatments are carried out with the same reliability as applications with high requirements for brilliance. Flexible system configurations and interfaces for the industry 4.0 integration allow for an optimal adjustment to all application situations.
Diagnostics on Gold by Plasmon Resonance
Authors: González Ana Belén , Pozo Jose 
Published: January 2019

AbstractAn emerging company, PhotonicSys, offers new products based on surface plasmon resonance (SPR) for diagnostics applications. In a discussion with EPIC experts Ana González and Jose Pozo, CEO Ibrahim Abdulhalim explains the benefits and applications for this kind of devices and the challenges that this technology is facing.
Synthesis of a novel DOPO‐based polyphosphoramide with high char yield and its application in flame‐retardant epoxy resins
Authors: Gangireddy Chandra Sekhar Reddy , Wang Xin , Kan Yongchun , Song Lei , Hu Yuan 
Published: January 2019

AbstractA novel and highly effective flame retardant (FR), DOPO‐TPMP oligomer, was synthesized by a simple condensation of 4‐(hydroxymethyl)‐2,6,7‐trioxa‐1‐phosphabicyclo[2.2.2]octane‐1‐oxide and phosphorus oxychloride followed by a polycondensation reaction with 6‐(2,5‐dihydroxyphenyl)‐6H‐dibenzo[c,e][1,2]oxaphosphinine‐6‐oxide. The chemical structure of DOPO‐TPMP was well characterized using Fourier transform infrared and NMR spectra. DOPO‐TPMP was used as an additive‐type FR for epoxy resin (EP). The FR properties of the resultant EP composites were investigated by limiting oxygen index (LOI) test, UL‐94 vertical burning test and cone calorimeter measurements. Specifically, the EP composite containing 10.0% DOPO‐TPMP achieved a LOI value of 36.1%, V‐0 rating in the UL‐94 test and a 58% reduction in peak heat release rate. Further mechanism analysis attributed the enhanced flame retardancy to the increased char yield on the addition of DOPO‐TPMP. © 2019 Society of Chemical Industry
Clinical Course of Motor Deficits from Lumbosacral Radiculopathy Due to Disk Herniation
Authors: Akuthota Venu , Marshall Ben , Boimbo Sandra , Osborne Mark C. , Garvan Cynthia S. , Garvan Gerard J. , Buzanowska Marzena , Sauerwein Kelly , Sridhar Balaji V. , Plastaras Christopher T. 
Published: January 2019

BackgroundThe clinical course of motor deficits from lumbosacral radiculopathy appears to improve with or without surgery. Strength measurements have been confined to manual muscle testing (MMT) and have not been extensively followed and quantified in prior studies.ObjectiveTo determine if motor weakness and patient‐reported outcomes related to lumbosacral radiculopathy improve without surgical intervention over the course of 12 months.DesignProspective observational cohort.SettingOutpatient academic spine practice.ParticipantsAdults with acute radicular weakness due to disk herniation.MethodsForty patients with radiculopathy and strength deficit were followed over a 12‐month period. Objective strength and performance tests as well as survey‐based measurements were collected at baseline and then every 3 months. Patients underwent comprehensive pain management and rehabilitation and/or surgical approaches as determined in coordination with the treating specialist. This study was approved by the institutional review board of Colorado.Main Outcome MeasurementsTesting of strength was through MMT, handheld dynamometer, and performance‐based testing. Furthermore, visual analog scale, modified Oswestry Disability Index, and 36‐Item Short Form Health Survey (SF‐36) were used to measure pain and disability outcomes.ResultsOf the 40 patients, 33 (82.5%) did not have surgery; 7 (17.5%) had surgery. Twenty‐four of the 33 patients (60%) did not undergo surgery and were followed for 12 months (Comprehensive Pain Management and Rehabilitation, Complete [CPM&R‐C]), and 9 (22%) did not have surgery and lacked at least one follow‐up evaluation (Comprehensive Pain Management and Rehabilitation, Incomplete [CPM&R‐I]). No statistically significant differences were found on baseline measures of strength deficits and SF‐36 domains between the CPM&R‐C, Surgery, and CPM&R‐I groups. Pain and disability scores in the Surgery group were significantly higher than in the CPM&R‐C at baseline. There were statistically significant improvements in all areas of strength, pain, and function when comparing measurements at the 12‐month follow‐up to baseline in the CPM&R‐C group.ConclusionsIndividuals with motor deficits due to lumbosacral radiculopathy improve over time regardless of treatment choice. Most did not choose surgery, and almost all of these patients regained full strength at 1 year. Strength recovery typically occurred in the first 3 months, but there was ongoing recovery over the course of a year.Level of EvidenceII
Assessing Plantar Sensation in the Foot Using the Foot Roughness Discrimination Test (FoRDT): A Reliability and Validity Study in Stroke
Authors: Gorst Terry , Freeman Jenny , Yarrow Kielan , Marsden Jonathan 
Published: January 2019

BackgroundThe plantar foot represents a sensory dynamometric map and is essential for balance and gait control. Sensory impairments are common, yet often difficult to quantify in neurological conditions, particularly stroke. A functionally oriented and quantifiable assessment, the Foot Roughness Discrimination Test (FoRDT), was developed to address these shortcomings.ObjectiveTo evaluate inter‐ and intrarater reliability, convergent and discriminant validity of the FoRDT.DesignTest‐retest design.SettingHospital outpatient.ParticipantsThirty‐two people with stroke (mean age 70 years) at least 3 months after stroke, and 32 healthy, age‐matched controls (mean age 70).Main Outcome MeasuresRoughness discrimination thresholds were quantified utilizing acrylic foot plates, laser cut to produce graded spatial gratings. Stroke participants were tested on three occasions, and by two different raters. Inter‐ and intrarater reliability and agreement were evaluated with Intraclass Correlation Coefficients and Bland‐Altman plots. Convergent validity was evaluated through Spearman rank correlation coefficients (rho) between the FoRDT and the Erasmus modified Nottingham Sensory Assessment (EmNSA).ResultsIntra‐ and interrater reliability and agreement were excellent (ICC =0.86 [95% CI 0.72‐0.92] and 0.90 [95% CI 0.76‐0.96]). Discriminant validity was demonstrated through significant differences in FoRDT between stroke and control participants (P < .001). Stroke fallers had statistically significant higher FoRDT scores compared with nonfallers (P = .01). Convergent validity was demonstrated through significant and strong correlations (rho) with the Erasmus MC Nottingham Sensory Assessment (r = .69, P < .01). Receiver operator characteristic curve analysis indicated the novel test to have excellent sensitivity and specificity in predicting the presence of self‐reported sensory impairments. Functional Reach test significantly correlated with FoRDT (r = .62, P < .01) whereas measures of postural sway and gait speed did not (r = .16‐.26, P > .05).ConclusionsThis simple and functionally oriented test of plantar sensation is reliable, valid, and clinically feasible for use in an ambulatory, chronic stroke and older population. It offers clinicians and researchers a sensitive and robust sensory measure and may further support the evaluation of rehabilitation targeting foot sensation.Level of EvidenceIII.