bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant, α-glucosidase inhibitory and in vitro antitumor activities of coumarin-benzothiazole hybrids
Authors: Gabr Moustafa T. 
Published: September 2018

Abstract
Coumarin-benzothiazole hybrids are antitumor agents based on their antioxidant and α-glucosidase inhibitory activities. Compounds 5a–c were selected by National Cancer Institute (NCI), USA, to be screened for antitumor activity at a single dose (10 μm) against a panel of 60 cancer cell lines. The most active compound 5c was further screened at a five-dose level by NCI. Compound 5c displays half maximal growth inhibition (GI50) values of 0.24 and 0.33 μm against central nervous system (CNS) cancer (SNB-75) and ovarian cancer (OVCAR-4) cell lines, respectively. Compounds 5a–c were also screened for their antioxidant and α-glucosidase inhibitory activities.
Memory, Gender and Recognition in
Le Morte Darthur
Authors: Hunter Mikayla 
Published: September 2018

Abstract
This article examines recognition motifs in earlier English romances to better understand female perception and the use of recognition tokens in Le Morte Darthur. Drawing on the work of Mary Carruthers and Elisabeth van Houts on medieval concepts of memory and emotion and Anne Lester on women’s association with the care and keeping of relics, as well as the social and legal roles of women preserving knowledge of familial and sexual relationships, this article argues that medieval English understanding of disguise-perception was gendered and that in medieval culture women were considered to be better at recognising individuals than men. The use of recognition tokens in Middle English romance reflects this gendered view of perception; recognition scenes in Le Morte Darthur uphold this view. In addition, the materiality and efficacy of the recognition tokens in romance denotes the nature of the relationship between the perceiver and the disguised or transformed individual. Thus, when Malory introduces a recognition-token exchange scene between Isolde and Tristan and then frustrates their later recollections and recognitions of each other, he infuses Tristan and Isolde’s relationship with a sense of unease that foreshadows their tragic end.
The Lost Tomb of Arthur and Guinevere at Glastonbury Abbey
Authors: Clancy Matt 
Published: September 2018

Abstract
The monks of Glastonbury Abbey excavated what they claimed were the relics of Arthur and Guinevere in 1191 and installed them in a lavish tomb inside the Abbey. This article explores the material culture of this tomb, incorporating both its use in reality and its representation in Arthurian romance texts. In doing so, it argues that the creation of the tomb directly influenced the development of the Arthurian romance tradition. A survey of the surviving evidence shows that the tomb was presented as that of a real king, suggesting that its creators sought to emulate medieval royal tombs. This article therefore addresses surviving representations of the tomb as a space that is simultaneously both real and imagined.
How Public Libraries are Keeping Pace with the Times: Core Services of Libraries in Informational World Cities
Authors: Born Christian , Henkel Maria , Mainka Agnes 
Published: September 2018

AbstractIn a survey of 31 informational world cities, we investigate the state of the art public library core services. For this study, we applied the core service catalog developed by (Mainka, A., S. Hartmann, L. Orszullok, I. Peters, A. Stallmann, and W. G. Stock. 2013. “Public Libraries in the Knowledge Society: Core Services of Libraries in Informational World Cities.”Libri63 (4): 295–319. 10.1515/libri-2013-0024), counted the services offered by the libraries and compared findings with the results from 2013, allowing us to calculate a score for each library and rank them accordingly. An overall improvement of the range of services was observed, with North American libraries taking the top three positions in the ranking. To get a clearer picture of the challenges facing libraries today, personal interviews were also conducted with (chief) librarians, especially concerning developments such as maker spaces, increasing demand for information literacy instruction and the changing role of physical library space. The results presented in this paper highlight best practice examples of library services in prototypical cities of the knowledge society.
Stability and convergence of a local discontinuous Galerkin finite element method for the general Lax equation
Authors: Wei Leilei , Mu Yundong 
Published: September 2018

Abstract
In this paper we develop and analyze the local discontinuous Galerkin (LDG) finite element method for solving the general Lax equation. The local discontinuous Galerkin method has the flexibility for arbitrary h and p adaptivity, and allows for hanging nodes. By choosing the numerical fluxes carefully we prove stability and give an error estimate. Finally some numerical examples are computed to show the convergence order and excellent numerical performance of proposed method.
Association of miRNA122 & ADAM17 with lipids among hypertensives in Nigeria
Authors: Meka Ijeoma A. , Anyim Obumneme B. , Enebe Joseph T. , Ukwaja Kingsley N. , Ugonabo Martin C. 
Published: September 2018

Abstract

Background
Dyslipidaemia and hypertension are established major risk factors for cardiovascular diseases. The suggested roles of miRNA-122 and ADAM17 in lipid metabolism can therefore be applied in the management of metabolic disorders. The authors’ aim was to determine the association between miRNA-122 and ADAM17, as well as the association between miRNA-122 and lipid fractions, in the study participants.

Method
A comparative cross-sectional study was conducted among 200 hypertensive patients and 100 non-hypertensive adult controls between May, 2015, and June, 2016, in Nigeria. Lipids were analysed with spectrophotometric methods whereas ADAM17 and miRNA-122 were analysed with enzyme linked immunosorbent assay and quantitative polymerase chain reaction, respectively.

Results
The mean (standard deviation [SD]) ages of 200 hypertensives and 100 controls were 56.3 (6.9) and 54.9 (8.3) years, respectively. miRNA-112 and ADAM17 had significantly higher values among dyslipidaemic individuvals compared with non-dyslipidaemic participants. The correlation between miRNA-122 and ADAM17 levels was strongly positive, r=0.82, p<0.05. LDL-cholesterol and total cholesterol also showed statistically significant positive correlation with miRNA-122, r=0.53, r=0.51, (p< 0.001) respectively.

Conclusion
In this study, miRNA-122 showed a strong correlation with ADAM17 and a positive correlation with LDL-cholesterol and total cholesterol. These findings support the stimulant roles of miRNA-122 and ADAM17 in lipid metabolism and thus could be used in the management of dyslipidaemia.
Sleep deprivation in Intensive Care Unit – systematic review
Authors: Medrzycka-Dabrowska Wioletta , Lewandowska Katarzyna , Kwiecień-Jaguś Katarzyna , Czyż-Szypenbajl Katarzyna 
Published: September 2018

Abstract

Background
Sleep disturbances in intensive care unit (ICU) patients have been studied worldwide for over 30 years. Factors contributing to sleep disturbances are still being identified, and therapeutic procedures aimed at the mitigation of such ailments are consequently being developed.

Objectives
The aim of this study was to review the literature on sleep disturbances in intensive care unit patients.

Material and Methods
MEDLINE PubMed, OVID, Web of Science, and EBSCO databases have been searched using adequate keywords.

Results
Sleep disorders in ICUs were common among all of the analysed articles. Noise plays a significant role in sleep interruption (11.5 - 17% of awakenings). It was noted that the introduction of “white noise” into the ICU environment proved unsuccessful in reducing the magnitude of changing noise levels. Nursing care activities significantly disturb nocturnal rest, and 42.7 such procedures per every 12-hour night shift were registered. Aggregating nursing care interventions was suggested in order to reduce the number of stimuli experienced by the patient.

Conclusion
Changes in sleep structure developing during an ICU stay may significantly contribute to sleep disorders once the hospitalisation is over.
Crystal structure of methyl 2-((1-(2-(methoxycarbonyl)benzyl)-1H-1,2,3-triazol-4-yl)methoxy)-1-naphthoate, C24H21N3O5
Authors: Sun Yutong , Hong Wei , Wang Hao 
Published: September 2018

Abstract
C24H21N3O5, orthorhombic, Pbca (no. 61), a = 8.4167(7) Å, b = 14.0370(10) Å, c = 34.664(3) Å, V = 4095.4(6) Å3, Z = 8, R
gt(F) = 0.0457, wR
ref(F
2) = 0.1001, T = 150(2) K.
Kinetic study on the decomposition of cellulose into 5-hydroxymethylfurfural in an ionic liquid/organic biphasic system
Authors: Zhang Heng , Wang Zhe , Yang Heng , Yang Hongyan 
Published: September 2018

Abstract
The kinetics of cellulose decomposition in an ionic liquid/organic solvent were investigated using microcrystalline cellulose as the raw material. Curve fitting of the cellulose degradation kinetic data was conducted using MATLAB. Results indicated that the catalytic decomposition reactions of cellulose, glucose and 5-hydroxymethylfurfural (5-HMF), along with the diffusion process of 5-HMF, were all first-order reactions in the biphasic system. The decomposition rate constants of cellulose, glucose and 5-HMF, along with the diffusion coefficient of 5-HMF (k5), in the biphasic system were obtained using the first-order reaction model. The organic solvent could suppress the formation of by-products to a certain extent and reduced the activation energy of cellulose, glucose and 5-HMF degradation by 4.24 %, 5.17 % and 3.73 %, respectively, compared with cellulose degradation in ionic liquid. The amount of organic solvent had little effect on glucose yield within the optimum reaction time and did not ascertain the presence of glucose in the organic solvent. k5 was relatively small and increased with an increase in temperature, reaction time and amounts of [BMIM]Cl, catalyst and organic solvent, with temperature exerting the greatest effect.
Heterodyne standing-wave interferometer / Heterodynes Stehende-Welle-Interferometer
Authors: Ortlepp Ingo , Manske Eberhard , Zöllner Jens-Peter , Rangelow Ivo 
Published: September 2018

Abstract
This manuscript describes a novel standingwave arrangement with two laser sources of different wavelengths, emitting towards each other. The resulting standing wave has a continuously moving intensity profile, a thin, transparent photo sensor is inserted into. When the sensor is moved along the optical axis a frequency shift, proportional to the velocity, occurs. This frequency shift can be evaluated for the purpose of interferometric length measurements.
Ein neues Detektorkonzept für die Flüssigchromatographie basierend auf einem Split-Ring-Resonator / A new detector concept for liquid chromatography based on a split-ring resonator
Authors: Gehl Adrian , Zimmermann Stefan 
Published: September 2018

Zusammenfassung
In der Flüssigchromatographie sind optische Detektoren weit verbreitet. Einige Substanzen, deren optische Eigenschaften kaum von denen der mobilen Phase abweichen, können von diesen Detektoren jedoch nicht erfasst werden. In dieser Arbeit wird daher ein einfaches elektromagnetisches Detektorprinzip basierend auf einem Split-Ring-Resonator vorgestellt, das die dieletrischen Eigenschaften von Substanzen in der mobilen Phase auswertet. Allererste Messungen mit verschiedenen Testsubstanzen bestätigen die grundlegende Funktionalität des vorgestellten Detektors.
Kontinuierliche laterale Abtastung von Oberflächen durch axiale Regelung des Arbeitsabstandes in einem Nanokoordinatenmessgerät mit einem hochfrequent fokusabstandsmodulierten, fasergekoppelten, konfokalen Punktsensor / Lateral closed-loop scans of surfaces using a nano coordinate measuring system and a high-speed focal-distance modulated fibre-coupled confocal sensor
Authors: Gröschl Andreas , Schaude Janik , Hausotte Tino 
Published: September 2018

Zusammenfassung
In diesem Artikel wird ein neues Messverfahren zur Oberflächenmessung bei gleichzeitiger axialer Regelung des Arbeitsabstandes eines hochfrequent fokusabstandsmodulierten, fasergekoppelten, konfokalen Punktsensors in einem Nanokoordinatenmessgerät (NMM- 1) [4] vorgestellt. Während bei diesem Verfahren alle bekannten Vorteile der Konfokaltechnik beibehalten werden, stellt die innovative Kombination einer fasergekoppelten Beleuchtung und Detektion mit einer akustisch getriebenen, modulierbaren Flüssigkeitsgradientenlinse (engl. tunable, acoustically driven gradient-index fluid lens, Abk. TAG-Linse) [10] zur hochfrequenten Abstandmodulation des Fokus zusammen mit einer neuartigen Signalverarbeitung auf Basis einer Lock-in-Verstärkung eine wesentliche Verbesserung dar. Durch die Anordnung und Auswertung ergibt sich im Gegensatz zu konventionellen konfokalen Punktsensoren eine nahezu lineare Kennlinie, wobei die Richtung der Abweichung der Messobjektoberfläche relativ zur Fokusebene des Objektivs eindeutig bestimmt werden kann. Es wird insbesondere die Verwendung des Sensors sowie die Nutzung der resultierenden Kennlinie zur Regelung der Oberflächenposition in einem Nanokoordinatenmessgerät gezeigt. Im Gegensatz zum Verfahren konventioneller Konfokalsensoren, bei der lateral flächenhafte Abtastungen auf vielen diskreten axialen Höhen durchgeführt werden, um daraus für jeden lateralen Messpunkt durch eine Maximalwertsuche einen Höhenwert zu ermitteln, kann durch die gezeigte Nachregelung eine Oberflächenerfassung durch eine einzige laterale Abstastung erfolgen. Die sich daraus ergebende immense Zeitersparnis ist nicht nur wesentlich ökonomischer sondern weist aufgrund zeitlicher thermischer Driften auch geringere Messabweichungen auf.
Parallelverarbeitung von RSSI-Signalen für ein lückenloses Monitoring des HF-Spektrums im 2,45 GHz ISM-Band / Parallel processing of RSSI signals for gapless monitoring of the 2.45 GHz ISM band
Authors: Solzbacher Thomas , Heynicke Ralf , Scholl Gerd 
Published: September 2018

Zusammenfassung
WirelessHART und speziell an industrielle Bedingungen adaptierte WLAN- und Bluetooth- Systeme sind Beispiele für drahtlose Kommunikationssysteme, die sich für die Vernetzung von Sensoren und Aktoren im industriellen Umfeld etabliert haben. Im April diesen Jahres wurde ein zusätzlicher drahtloser Standard IO-Link Wireless [6] für die diskrete Fertigungsautomatisierung verabschiedet. Aufgrund der weltweiten Verfügbarkeit, was wiederum zu einer hohen Verfügbarkeit von kostengünstigen HF-Kommunikationskomponenten führt, wird häufig das lizenzfreie ISM-Band im 2,45 GHz-Bereich intensiv für die Kommunikation genutzt. Um Koexistenzprobleme zwischen den unterschiedlichen Systemen zu vermeiden, wurden bislang im wesentlichen Listen-Before- Talk, Frequency-Hopping und Blacklisting-Verfahren eingesetzt. Spektrumanalysatoren werden in der Regel offline als Monitoring- und Diagnose-Werkzeuge genutzt. In diesem Beitrag wird vorgeschlagen, diese zukünftig auch online in den laufenden Prozess zu integrieren, um eine mögliche Interferenz zwischen den um den Funkkanal konkurrierenden Kommunikationssystemen rechtzeitig zu erkennen bzw. vorherzusagen. Dazu müssen diese in der Lage sein, alle bekannten drahtlosen Systeme schnell und zuverlässig zu detektieren und zu klassifizieren. Ferner muss das Preisniveau dieser Spektrumanalysatoren erheblich unter dem von Labormessgeräten liegen, so dass diese im Sinne eines zusätzlichen Sensors einfach über bekannte Engineering-Werkzeuge in die Kommunikation eingebunden werden können.
Gene expression data analysis for characterizing shared and type specific mechanisms of HCC and B-CLL
Authors: Sucularli Ceren , Toprak Ugur , Arslantas Melda 
Published: September 2018

Abstract

Background
Comparing gene expression profiles using gene expression datasets of different types of tumors is frequently used to identify molecular mechanisms of cancer. This study aimed to find shared and type specific gene expression profiles of hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL).

Material and methods
Gene expression microarrays for HCC and B-CLL and RNA-sequencing expression data for liver HCC and lymphoid neoplasm diffuse large B-cell lymphoma (DLBC) were analyzed and differentially expressed probe sets or genes for each cancer type were detected. Probe sets and genes that were shared or specifically expressed in both cancer types were identified. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) terms for Biological Process (BP) annotations were performed.

Results
According to our analysis shared upregulated genes were mainly annotated in cell cycle processes. Some of the genes that changed only in HCC were annotated in cell cycle and metabolic processes, and some of the genes, altered only in B-CLL, were annotated in immune response and hemopoiesis.

Conclusion
These results contribute to cancer research that aim to find the conserved gene expression profiles in different cancer types and widen the knowledge of HCC and B-CLL specific mechanisms.
Doxycycline hydrate and doxycycline hydrochloride dihydrate – crystal structure and charge density analysis
Authors: Tchoń Daniel , Makal Anna , Gutmann Matthias , Woźniak Krzysztof 
Published: September 2018

Abstract
High-resolution low-temperature X-ray diffraction experiments for doxycycline monohydrate and hydrochloride dihydrate have been performed. Translation-Libration-Screw (TLS) analysis for both crystal forms as well as the data from neutron diffraction experiment for hydrochloride combined with the Hansen-Coppens formalism resulted in precise charge density distribution models for both the zwitterionic monohydrate and a protonated hydrochloride crystal forms. Their detailed topological analysis suggested that the electron structure of doxycycline’s amide moiety undergoes significant changes during protonation due to formation of a very strong resonance-assisted hydrogen bond. A notably increased participation of amide nitrogen atom and hydrogen-accepting oxygen atom in the resonance upon doxycycline protonation was observed. A comparison of TLS- and neutron data-derived hydrogen parameters confirmed the experimental neutron data to be vital for proper description of intra- and inter-molecular interactions in this compound. Finally, calculated lattice and interaction energies quantified repulsive Dox-Dox interactions in the protonated crystal form of the antibiotic, relating with a good solubility of doxycycline hydrochloride relative to its hydrate.
New Generation of Hoek Cells
Authors: Roshan Hamid , Lv Adelina , Xu Yun , Masoumi Hossein , Regenauer-Lieb Klaus 
Published: September 2018

Abstract
A new generation of Hoek cells was designed and built to conduct triaxial testing on rock-like materials. The new design has the advantages of both conventional Hoek cells (e.g., minimal preparation and setup time) and conventional triaxial systems (e.g., on specimen radial deformation measurement), and it is capable of measuring the permeability at a controlled temperature. This quick release triaxial cell is robust, fast, and cost efficient and can be used for high pressure–high temperature experiments. In order to assess the robustness of the designed cell, a number of triaxial tests were carried out on different rock specimens (sandstone and marble) at different confining pressures (10, 30, and 50 MPa) and controlled temperatures (30°C and 60°C). In addition, the permeability measurement was conducted on the sandstone specimen under triaxial loading having 10 MPa confining pressure and 30°C temperature.
Visuomotor Correlates of Conflict Expectation in the Context of Motor Decisions
Authors: Derosiere Gerard , Klein Pierre-Alexandre , Nozaradan Sylvie , Zénon Alexandre , Mouraux André , Duque Julie 
Published: September 2018

Many behaviors require choosing between conflicting options competing against each other in visuomotor areas. Such choices can benefit from top-down control processes engaging frontal areas in advance of conflict when it is anticipated. Yet, very little is known about how this proactive control system shapes the visuomotor competition. Here, we used electroencephalography in human subjects (male and female) to identify the visual and motor correlates of conflict expectation in a version of the Eriksen Flanker task that required left or right responses according to the direction of a central target arrow surrounded by congruent or incongruent (conflicting) flankers. Visual conflict was either highly expected (it occurred in 80% of trials; mostly incongruent blocks) or very unlikely (20% of trials; mostly congruent blocks). We evaluated selective attention in the visual cortex by recording target- and flanker-related steady-state visual-evoked potentials (SSVEPs) and probed action selection by measuring response-locked potentials (RLPs) in the motor cortex. Conflict expectation enhanced accuracy in incongruent trials, but this improvement occurred at the cost of speed in congruent trials. Intriguingly, this behavioral adjustment occurred while visuomotor activity was less finely tuned: target-related SSVEPs were smaller while flanker-related SSVEPs were higher in mostly incongruent blocks than in mostly congruent blocks, and incongruent trials were associated with larger RLPs in the ipsilateral (nonselected) motor cortex. Hence, our data suggest that conflict expectation recruits control processes that augment the tolerance for inappropriate visuomotor activations (rather than processes that downregulate their amplitude), allowing for overflow activity to occur without having it turn into the selection of an incorrect response.SIGNIFICANCE STATEMENTMotor choices made in front of discordant visual information are more accurate when conflict can be anticipated, probably due to the engagement of top-down control from frontal areas. How this control system modulates activity within visual and motor areas is unknown. Here, we show that, when control processes are recruited in anticipation of conflict, as evidenced by higher midfrontal theta activity, visuomotor activity is less finely tuned: visual processing of the goal-relevant location was reduced and the motor cortex displayed more inappropriate activations, compared with when conflict was unlikely. We argue that conflict expectation is associated with an expansion of the distance-to-selection threshold, improving accuracy while the need for online control of visuomotor activity is reduced.