bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis
Authors: Li Zhean , Luo Lingling , Ju Xiaohui , Huang Shisheng , Lei Liqun , Yu Yanying , Liu Jia , Zhang Pumin , Chi Tian , Ma Peixiang , Huang Cheng , Huang Xingxu , Ding Qiang , Zhang Yu 
Published: November 2024

AbstractHost cell-encoded deaminases act as antiviral restriction factors to impair viral replication and production through introducing mutations in the viral genome. We sought to understand whether deaminases are involved in SARS-CoV-2 mutation and replication, and how the viral factors interact with deaminases to trigger these processes. Here, we show that APOBEC and ADAR deaminases act as the driving forces for SARS-CoV-2 mutagenesis, thereby blocking viral infection and production. Mechanistically, SARS-CoV-2 nucleocapsid (N) protein, which is responsible for packaging viral genomic RNA, interacts with host deaminases and co-localizes with them at stress granules to facilitate viral RNA mutagenesis. N proteins from several coronaviruses interact with host deaminases at RNA granules in a manner dependent on its F17 residue, suggesting a conserved role in modulation of viral mutagenesis in other coronaviruses. Furthermore, mutant N protein bearing a F17A substitution cannot localize to deaminase-containing RNA granules and leads to reduced mutagenesis of viral RNA, providing support for its function in enhancing deaminase-dependent viral RNA editing. Our study thus provides further insight into virus-host cell interactions mediating SARS-CoV-2 evolution.
Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB
Authors: Sun Yongzhan , Zou Quan , Yu Huizheng , Yi Xiaoping , Dou Xudan , Yang Yu , Liu Zhiheng , Yang Hong , Jia Junya , Chen Yupeng , Sun Shao-Kai , Zhang Lirong 
Published: November 2024

Abstract
Melanin-like nanoparticles (MNPs) have recently emerged as valuable agents in antioxidant therapy due to their excellent biocompatibility and potent capacity to scavenge various reactive oxygen species (ROS). However, previous studies have mainly focused on acute ROS-related diseases, leaving a knowledge gap regarding their potential in chronic conditions. Furthermore, apart from their well-established antioxidant effects, it remains unclear whether MNPs target other intracellular molecular pathways. In this study, we synthesized ultra-small polyethylene glycol-incorporated Mn2+-chelated MNP (MMPP). We found that MMPP traversed the glomerular filtration barrier and specifically accumulated in renal tubules. Autosomal dominant polycystic kidney disease (ADPKD) is a chronic genetic disorder closely associated with increased oxidative stress and featured by the progressive enlargement of cysts originating from various segments of the renal tubules. Treatment with MMPP markedly attenuated oxidative stress levels, inhibited cyst growth, thereby improving renal function. Interestingly, we found that MMPP effectively inhibits a cyst-promoting gene program downstream of the cAMP-CREB pathway, a crucial signaling pathway implicated in ADPKD progression. Mechanistically, we observed that MMPP directly binds to the bZIP DNA-binding domain of CREB, leading to competitive inhibition of CREB’s DNA binding ability and subsequent reduction in CREB target gene expression. In summary, our findings identify an intracellular target of MMPP and demonstrate its potential for treating ADPKD by simultaneously targeting oxidative stress and CREB transcriptional activity.
Enhancing the activity and stability of Fe/Co-based nitrogen-doped carbon with richer nitrogen and metal-N active sites towards oxygen reduction reactions
Authors: Wu Zeqi , Zhao Zhenlu 
Published: November 2024

Based on the nitrogen enrichment and coordination effects with Fe/Co from polydopamine (PDA), Fe/Co-based nitrogen-doped carbon (Fe/Co-NC RN III) was prepared and exhibited good ORR activity and stability.
Social–Emotional Functioning of Children With Different Hearing Status and Diverse Cultural Background
Authors: Kawar Khaloob , Michael Rinat 
Published: November 2024

Purpose:
The study investigated the social–emotional functioning of children with typical hearing and deaf and hard of hearing (D/HH) children from diverse cultural backgrounds in Israel through parental reports.

Method:
A total of 242 parents from both Arabic and Jewish communities participated: 130 were parents of D/HH children and 112 were parents of children with typical hearing. The Strengths and Difficulties Questionnaire and a background questionnaire were used.

Results:
Results revealed increased total difficulties, emotional symptoms, and peer problems as reported by parents of D/HH children. Jewish parents of D/HH children reported greater total difficulties, conduct problems, and peer problems than Arab parents. Significant gender differences were found, with parents of boys reporting higher levels of hyperactivity/inattention and lower prosocial behavior. Among D/HH children, Arab parents reported higher peer problems among hearing aid users compared to cochlear implant users, whereas Jewish parents reported the opposite trend.

Conclusion:
These findings highlight the significant social–emotional challenges faced by D/HH children, particularly in peer interactions, and underscore the need for tailored interventions that consider cultural differences.
Aging monitoring method for IGBT module based on conduction voltage drop in bridge‐arm short‐circuit
Authors: Liu Shiyuan , Zhang Jingwei , Zhao Cui , Liu Kun , He Fangyuan 
Published: November 2024

AbstractInsulated gate bipolar transistors (IGBTs) serve as the pivotal components within power conversion systems, and given the harsh conditions they endure, evaluating their aging is of paramount importance. Traditional offline aging monitoring method are relatively complex. Based on the conduction voltage drop as the characteristic quantity of IGBT aging, a simpler technique for extracting this parameter is presented, facilitating the assessment of IGBT aging status. Incorporating the working principle of the IGBT bridge‐arm short‐circuit, a conduction voltage drop model has been established. A composite aging electrical parameter is used to eliminate the impact of degradation in the bond wire of the current source device. By engineering a closed‐loop gate drive circuit with adjustable voltage, the short‐circuit current is maintained constant, thereby facilitating the acquisition of a consistent conduction voltage drop. A conduction voltage extraction circuit is proposed, in which a resistance‐capacitance discharging time is equivalent to the conduction voltage drop to replace the analogue‐to‐digital circuit. By decreasing the amount of active zone of the chip in IGBT module for increased conduction voltage drop to simulate aging state, the proposed method with the driving circuit is experimentally validated as feasible and reliable.
Gaia Data Release 3: Spectroscopic binary-star orbital solutions
Authors: Gosset E. , Damerdji Y. , Morel T. , Delchambre L. , Halbwachs J.-L. , Sadowski G. , Pourbaix D. , Sozzetti A. , Panuzzo P. , Arenou F. 
Published: November 2024

Context. The Gaia satellite constitutes one of ESA’s cornerstone missions. Being primarily an astrometric space experiment measuring positions, proper motions, and parallaxes for a huge number of stars, it also performs photometric and spectrophotometric observations. Gaia operates a medium-dispersion spectrometer, known as Radial Velocity Spectrometer (RVS), which provides spectra and radial velocity (RV) time series.
Aims. The paper is focussed on the analysis of the RV time series. We fit orbital and trend models, restricting our study to objects of spectral types F-G-K that are brighter than a magnitude of 12, presenting only one single spectrum (SB1).
Methods. Suitable time series were processed and analysed on an object-per-object basis, providing orbital or trend solutions. The results of the various fits were further filtered internally on the basis of several quality measures to discard spurious solutions. The objects with solely a spectroscopic solution were classified in one of the three classes: SB1 (eccentric model), SB1C (circular model), or TrendSB1 (mere trend model).
Results. We detail the methods used in this work and describe the derived parameters and results. After a description of the models considered and the related quality tests of the fit, we detail the internal filtering process aimed at rejecting bad solutions. We also present a full validation of the pipeline. A description of the current content of the catalogue is also provided.
Conclusions. We present the SB1, SB1C, and TrendSB1 spectroscopic solutions contained in the SB subcatalogue, part of the DR3 catalogue. We deliver some 181 327 orbital solutions in class SB1, 202 in class SB1C, and 56 808 in the associated class TrendSB1. This is a first release and the delivered SB subcatalogue could be further tuned and refined. However, the majority of the entries are correct. Thus, this data set constitutes by far the largest set of spectroscopic orbital solutions to be computed.
Forgotten treasures in the HST/FOC UV imaging polarimetric archives of active galactic nuclei
Authors: Barnouin T. , Marin F. , Lopez-Rodriguez E. 
Published: November 2024

Context. The Mrk 463 system is known to host two powerful sources that are separated by about 4 kpc, which were both identified as active galactic nuclei (AGN). This makes the Mrk 463 system a unique laboratory for studying the geometry and dynamics of galaxy merging and its relation to AGN duty cycles.
Aims. The eastern nucleus, Mrk 463E, is the brighter of the two and thus a prime target for a polarimetric study. It is classified as a Seyfert 2 galaxy, meaning that high polarization degrees from scattering off electrons and dust in the polar winds are expected.
Methods. In the continuity of our series of papers, we reduced archived and previously unpublished polarization observations obtained with the Faint Object Camera on board the Hubble Space Telescope to obtain a high-resolution near-ultraviolet polarization map of the Mrk 463E nuclei. We coupled this map to near-infrared and X-ray observations to obtain a clear picture of the geometric arrangement of matter around the core of Mrk 463E.
Results. We found that the nucleus location is farther south of the optical peak flux than previously estimated. The strongly polarized conical wind has a half-opening angle of ∼15° and displays three main periods of mass ejection. Its polarization allowed us to estimate the AGN inclination toward the observer (∼55°). Finally, our maps revealed a streamer connecting Mrk 463E and Mrk 463W, with a tentative detection of a large kiloparsec-scale ordered magnetic field connecting both galaxies.
Conclusions. This unpublished observation finally offered more than the original proposal asked for and allowed us to derive tight geometric and dynamical constraints for Mrk 463E. High-resolution radio maps and infrared polarimetry are now necessary to further study the jet and the newly discovered streamer.
Explanation of the exceptionally strong timing noise of PSR J0337+1715 by a circum-ternary planet and consequences for gravity tests
Authors: Voisin G. , Cognard I. , Saillenfest M. , Tauris T. M. , Wex N. , Guillemot L. , Theureau G. , Freire P. C. C. , Kramer M. 
Published: November 2024

Context. Timing of pulsar PSR J0337+1715 provides a unique opportunity to test the strong equivalence principle (SEP) with a strongly self-gravitating object. This is due to its unique situation in a triple stellar system with two white dwarfs.
Aims. Our previous study suggested the presence of a strong low-frequency residual signal in the timing data, and we set out to model this signal on a longer dataset in order to determine its nature and improve accuracy.
Methods. We considered three models: chromatic red noise, achromatic red noise, and a small planet in a hierarchical orbit with the triple stellar system. These models were implemented in our numerical timing model. We performed Bayesian inference of posterior distributions. Best fits were compared using information-theoretic criteria.
Results. We rule out chromatic red noise from dispersion-measure variations. Achromatic red noise or a planet in Keplerian orbit provide the best fits. If the residual signal is red noise, then it appears exceptionally strong. When assuming the presence of a planet, we obtained a marginal detection of mutual interactions that allowed us to constrain its mass to ∼0.5 MMoon as well as its inclination. The latter is intriguingly coincident with a Kozai resonance. We show that a longer observation span will ultimately lead to a clear signature of the planet model due to its mutual interactions with the triple system. We produce new limits on SEP violation: |Δ|< 1.5 ⋅ 10−6 or |Δ|< 2.3 ⋅ 10−6 at a 95% confidence level under the planet or red-noise hypothesis, respectively. This model dependence emphasises the need for additional data and model selection. As a by-product, we estimated a rather low supernova kick velocity of ∼110 − 125 km/s, strengthening the idea that it is a necessary condition for the formation of pulsar triple systems.
Akzeptanz einer digitalen Rehabilitationsnachsorge bei
Muskel-Skelett-Erkrankungen: eine Kohortenstudie
Authors: Prehn Johanna , Remus Lea , Bethge Matthias 
Published: November 2024

Zusammenfassung
Hintergrund Die Studie untersuchte die Akzeptanz einer digitalen
Rehabilitationsnachsorge in Form der Caspar-App für Rehabilitand*innen mit
Muskel-Skelett-Erkrankungen. Die wichtigsten Einflussfaktoren auf die
Nutzungsabsicht und die tatsächliche Nutzung sollten identifiziert werden. Die
Auswahl der Variablen basierte auf dem Technology Acceptance Model 3 (TAM 3).
Material und Methoden Es wurden Rehabilitand*innen für eine Befragung mit
zwei Zeitpunkten rekrutiert. Bei der Erstbefragung wurden u. a. mögliche
Determinanten von Nutzungsabsicht und Nutzung erhoben. Bei der Zweitbefragung
wurden u. a. die gewählte Form der Nachsorge und die Gründe gegen eine
App-Nutzung erfragt. Die Zusammenhänge der Einflussfaktoren wurden durch ein
generalisiertes Strukturgleichungsmodell (GSEM) geschätzt.
Ergebnisse An der Erstbefragung nahmen 152 und an der Zweitbefragung 64
Rehabilitand*innen teil. Die Befragten, die sich für ein konventionelles
Nachsorgeangebot entschieden haben, nannten als Hauptgrund dafür die Annahme,
mit der App nicht die gewünschten Ergebnisse zu erzielen (55%). Wir fanden
starke Zusammenhänge zwischen Ergebniserwartungen und der wahrgenommenen
Nützlichkeit sowie zwischen der wahrgenommenen Nützlichkeit und der
Nutzungsabsicht. Die Assoziation einer hohen Nutzungsabsicht und tatsächlicher
Nutzung konnte bestätigt werden.
Schlussfolgerungen Der starke Einfluss der Ergebniserwartungen und die
geringe Nutzung der digitalen Rehabilitationsnachsorge könnten in der hohen
Bedeutung physischer Übungen mit Therapeutinnen liegen, die für die
Rehabilitation von Muskel-Skelett-Erkrankungen zentral sind. Die beobachteten
Einflüsse der wahrgenommenen Benutzerfreundlichkeit und Nützlichkeit auf die
Nutzungsabsicht und Nutzung unterstützen die Annahmen des TAM 3. Die wichtigste
Handlungsempfehlung ist, den Rehabilitand*innen die Nicht-Unterlegenheit einer
digitalen Rehabilitationsnachsorge in Form der Caspar-App aufzuzeigen.
Pelvic venous disorders in women – diagnosis and therapy
Authors: Paulus Tobias , Minko Peter , Petersen Tim-Ole , Hoffmann Ralf-Thorsten , Kern Peter , Abolmaali Nasreddin 
Published: November 2024

AbstractChronic pelvic pain may cause a significant reduction in the quality of life for affected women, and the extent of the limitation is often underestimated. Chronic pain can lead to lifelong problems. Currently, PCS is probably significantly underdiagnosed as a cause of chronic pelvic pain in women. To diagnose PCS, other common causes of chronic pelvic pain must be excluded and typical changes in pelvic vein syndrome must be detected, ideally using MR phlebography. If the indication is correct and the procedure is carried out appropriately – ideally by experienced interventionalists certified according to DeGIR/EBIR – the symptoms can be eliminated in the long term with a high success rate and few complications. Simultaneous psychotherapeutic treatment should always be discussed with the patients.
Aloe vera and the Proliferative Phase of Cutaneous Wound Healing: Status Quo Report on Active Principles, Mechanisms, and Applications
Authors: Lee Zhuang Min , Goh Bey Hing , Khaw Kooi Yeong 
Published: November 2024

Abstract
Aloe vera is commonly used as traditional medicine for cutaneous wound healing. Nonetheless, the wound healing mechanisms of Aloe vera remain unclear. This review aims to provide insight into the molecular mechanisms of Aloe vera in promoting cutaneous wound healing, with particular emphasis on the mechanisms that stimulate cell proliferation and migration. Aloe vera has been shown to upregulate growth factors such as keratinocyte growth factor-1 (KGF-1), transforming growth factor-β (TGF-β), cyclin D1, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (bFGF), and microfibril-associated glycoprotein 4 (MFAP4), as well as collagen, fibrillin, elastin, α-smooth muscle actin (α-SMA), integrins, and platelet endothelial cell adhesion molecule 1 (PECAM-1, also known as CD31), while downregulating the expression of matrix metalloproteinases (MMPs). In addition,
Aloe vera was also found to upregulate PI3K/Akt and MAPK pathways, as well as the TGF-β signalling pathway via Smad proteins. Furthermore, molecular docking studies revealed that certain chemical constituents of Aloe vera bind to some of the forementioned growth factors or signalling molecules. With regards to current applications, although human clinical trials have reported positive results from using Aloe vera in healing open wounds and burns and alleviating some inflammatory skin diseases, the current commercial uses of Aloe vera remain largely focused on cosmetic products. Thus, greater advances are required to promote the use of Aloe vera products in clinical settings.
Crural Diaphragm Density in Respiratory Complications after Video-Assisted Thoracoscopic Surgery Lobectomy
Authors: Bellini Alice , Vizzuso Antonio , Sterrantino Sara , Ciarrocchi Angelo Paolo , Piciucchi Sara , Giampalma Emanuela , Stella Franco 
Published: November 2024

Abstract
Background Respiratory muscle strength affects pulmonary function after lung resection; however, the role of diaphragm density, an emerging index of muscle quality, remains unexplored. We investigated the role of crural diaphragm density (CDD) in respiratory complications (RC) after video-assisted thoracoscopic surgery (VATS) lobectomy for lung cancer.
Methods A total of 118 patients were retrospectively enrolled between 2015 and 2022. Exclusion criteria were neoadjuvant therapy, thoracic trauma, and previous cardiothoracic and abdominal surgery. Demographic, functional, and radiological data were collected. The CDD in Hounsfield Unit (HU) was defined as the average of the density of the right and left crural diaphragm at the level of the median arcuate ligament on computed tomography axial images. RC included sputum retention, respiratory infections, atelectasis, pneumonia, respiratory failure, and acute respiratory distress syndrome.
Results The prevalence of postoperative RC was 41% (48 of 118). RC occurred mostly in males (64.6 vs. 44.3%, p = 0.04), current smokers (41.7 vs. 21.4%, p = 0.02), a longer surgical procedure (210 vs. 180 minutes, p = 0.04), and a lower CDD (42.5 vs. 48 HU, p = 0.05). The optimal cutoff of CDD was 39.75 HU (sensitivity 43%, specificity 82%, accuracy 65%, area under the curve: 0.62, p = 0.05), slightly above the threshold for reduced muscle mass (<30 HU). By multivariable logistic regression a CDD ≤ 39.75 HU (hazard ratio [HR]: 3.134 [95% confidence interval, CI: 1.111–8.844], p = 0.03) and current smoking (HR: 2.733 [95% CI: 1.012–7.380], p = 0.05) were both independent risk factors of postoperative RC.
Conclusion The CDD seems to be a simple and useful tool for predicting RC after VATS lobectomy, especially among current smokers. Such patients, identified early, could benefit from preoperative functional and nutritional rehabilitation.
Photon-Counting Detector CT: Advances and Clinical Applications in Cardiovascular Imaging
Authors: Hagar Muhammad Taha , Schlett Christopher L , Oechsner Tim , Varga-Szemes Akos , Emrich Tilman , Chen Xiao Yan , Kravchenko Dmitrij , Tremamunno Giuseppe , Vecsey-Nagy Milán , Molina-Fuentes Moises Felipe , Krauss Tobias , Taron Jana , Schuppert Christopher , Bamberg Fabian , Soschynski Martin 
Published: November 2024

AbstractSince the approval of the first dual-source photon-counting detector CT (PCD-CT) in the fall of 2021, significant insights have been gained in its application for cardiovascular imaging. This review aims to provide a comprehensive overview of the current state of knowledge and the growing body of research literature, illustrating innovative applications and perspectives through case examples.We conducted a structured literature review, identifying relevant studies via Google Scholar and PubMed, using the keywords “photon-counting detector”, “cardiovascular CT”, “cardiac CT”, and “ultra-high-resolution CT”. We analyzed studies published since January 2015. Additionally, we integrated our own clinical experiences and case examples.In addition to the well-known benefit of increased temporal resolution offered by dual-source scanners, dual-source PCD-CT provides three key advantages: 1) Optimized geometric dose efficiency with an improved contrast-to-noise ratio, 2) intrinsic spectral sensitivity, and 3) the ability for ultrahigh-resolution CT. This technology enables improved image quality or radiation dose reduction in established cardiovascular protocols. Its use in non-invasive cardiac diagnostics for obese patients, those with a high plaque burden, or after stent implantation appears technically feasible, potentially expanding the scope of CT. The spectral sensitivity also allows tailored image acquisition, reducing metallic artifacts and contrast agent doses in patients with renal impairment. Early studies and clinical experience support these potential applications of PCD-CT in cardiovascular diagnostics, suggesting workflow optimization and improved patient management.However, challenges remain, including high costs, large data volumes, somewhat longer reconstruction times, and technical difficulties in combining spectral sensitivity with ultra-high resolution. Prospective randomized studies with clinical endpoints are lacking to confirm the clear advantage over conventional scanners. Future research should focus on endpoint-based studies and robust cost-benefit analyses to evaluate the potential of this technology and facilitate its evidence-based integration in clinical practice.