bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
Authors: Karakas Didem , Cevatemre Buse , Oral Arzu Y. , Yilmaz Veysel T. , Ulukaya Engin 
Published: April 2019

Background:Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a lifethreatening disease. Therefore novel compounds are needed to improve the overall survival.Methods:In our study, it was aimed to evaluate the anti-cancer activity of newly synthesized Platinum (II) [Pt(II)] complex on DU145, LNCaP and PC-3 prostate cancer cell lines. The cytotoxic activity of Pt(II) complex was tested by SRB and ATP cell viability assays. To detect the mode of cell death; fluorescent staining, flow cytometry and western blot analyses were performed.Results:The Pt(II) complex treatment resulted in a decrease in cell viability and increasing levels of apoptotic markers (pyknotic nuclei, annexin-V, caspase 3/7 activity) and a decrease in mitochondrial membrane potential in a dose dependent manner. Among cell types, tested PC-3 cells were found to be more sensitive to Pt(II) complex, demonstrating elevation of DNA damage in this cell line. In addition, Pt(II) complex induced Endoplasmic Reticulum (ER) stress by triggering ROS generation. More importantly, pre-treatment with NAC alleviated Pt(II) complex-mediated ER stress and cell death in PC-3.Conclusion:These findings suggest an upstream role of ROS production in Pt(II) complex-induced ER stressmediated apoptotic cell death. Considering the ROS-mediated apoptosis inducing the effect of Pt(II) complex, it warrants further evaluation as a novel metal-containing anticancer drug candidate.
Characteristic Performance of OLED Based on Hole Injection, Transport and Blocking Layers
Authors: Negi Shubham , Mittal Poornima , Kumar Brijesh 
Published: April 2019

Background:
Organic Light Emitting Diodes have emerged as a potential candidate for
being used as the display because of their remarkable performance. In the past decade, a lot of interest
was shown in their development and improvement. Scientists utilized different methods for
enhancing their performance which included the change in OLEDs architecture. Different supporting
layers (charge injection, transportation and blocking) are added in the architecture to enhance
the performance of OLED. Some of the patents related to the application of the OLED have also
been reviewed to observe the utilization of the present work in those applications.

Objective:
The motive of this research article is to analyze impacts the impact of different layers on
the performance of OLED.

Methods:
The objective is achieved by systematically analyzing the impact of different layers on
the OLED. The analysis commenced by investigating the properties of the basic OLED consisting
of the emission layer only. Thereafter, in succession different supporting layers are added to the
OLED architecture. Subsequently, after adding each layer, OLED device is analyzed and its properties
are determined. Finally, the performance of different layers is compared.

Results:
The outcome of the above research study shows that these supporting layers are significantly
able to enhance the performance of the OLED. Step by step layers are added to the architecture
and enhancement in the performance is observed. There is an improvement of 13% to 38% not
over the basic OLED architecture, but over the multilayered OLED device, which is already far
better than the basic OLED.

Conclusion:
Therefore, from the analyses, it can be concluded that the different layers are significant
for the OLED architecture and improve the performance of the OLED considerably.
The Tightly Regulated and Compartmentalised Import, Sorting and Folding of Mitochondrial Proteins
Authors: Cassina Laura , Casari Giorgio 
Published: April 2019

Mitochondria are eukaryotic intracellular organelles that still bear the signatures of their prokaryotic ancestor
and require nuclear assistance. They generously dispense energy to cells, but are also involved in several biosynthetic
processes, as well as in cell signalling pathways and programmed cell death.
Mitochondria are partitioned into four intra-organelle compartments: the outer membrane, the inner membrane, the
intermembrane space and the matrix. Each compartment contains a unique set of proteins and a personalised system for
guaranteeing protein homeostasis.
What follows is a survey of the function and topology of the multiple systems that operate the concerted action of protein
sorting and folding in the four mitochondrial compartments.
Perspectives for Early Genetic Screening of Lactose Intolerance: - 13910C/T Polymorphism Tracking in the MCM6 Gene
Authors: A.S. Arroyo Marta , P. Lopes Ana Cláudia , B. Piatto Vania , Victor Maniglia José 
Published: April 2019

Introduction:
For many years Lactose intolerance has been, considered as a universal problem in many children
and adults.

Objective:
The aim is to investigate the prevalence of polymorphism -13910C/T, in a neonatal tracking, for
early diagnosis of lactose tolerance/intolerance. Materials and Methods: In a cross-sectional study of 310 Brazilian
newborns, DNA was extracted from leukocyte umbilical cord and specific primers were used to amplify the region that
encloses the -13910C/T polymorphism of the MCM6 gene, using the polymerase chain reaction and the restriction
fragment length polymorphism tests.

Results:
One hundred and sixty (52%) male newborns and 150 (48%) female new
borns were evaluated. Out of these, 191 (62%) presented CC genotype (lactose intolerant), 95 (31%) CT genotype, and 24
(7%) TT genotype, comprising a total of 119 (38%) lactose tolerant newborns. Accordingly the newborns´ gender
distribution in relation to the phenotypes has been found; 97 (32%) of male gender and 94 (30%) of female gender lactose
intolerant, and 63 (20%) male and 56 (18%) female lactose tolerant newborns, not being such distribution statistically
significant (p = 0.801).

Conclusions:
The molecular analysis made possible the identification of the presence or absence of
lactase persistence variant in the Brazilian newborns. The neonatal molecular diagnosis can optimize the follow-up of
positive results in newborn screening for lactose intolerance.
Performance Analysis of Efficient and Low Complexity MIMO-OFDM System Using Modified V-BLAST
Authors: Yadav Brijesh Kumar , Singh Rabindra Kumar 
Published: April 2019

Background and Objective:
To analyze the performance of MIMO-OFDM system,
VBLAST detection suffers from computational complexity as well as high BER.

Methods:
To improve the BER performance and to reduce the computational complexity of receiver,
we propose a modified VBLAST detection in MIMO-OFDM Systems.

Results:
Simulation using MATLAB shows the improvement in computational complexity and in BER.

Conclusion:
This modified VBLAST reduces the complexity of MIMO-OFDM System to 44.2% and
improvement in BER as compared to conventional VBLAST based MIMO-OFDM System.
Cocoa Pulp as Alternative Food Matrix for Probiotic Delivery
Authors: Guimarães Gabriele M. , Soares Letícia A. , Silva Tuânia N.L. , de Carvalho Iracema L.Q. , Valadares Helder M.S. , Sodré George A. , Gonçalves Daniel B. , Neumann Elisabeth , Da Fonseca Flávio G. , Vinderola Gabriel , Granjeiro Paulo A. , de Magalhães Juliana T. 
Published: April 2019

Background:
For screening probiotic strains with viability and stability in non-dairy
foods for health benefits, we revised all patents relating to probiotics in food.

Objective:
Screening of potential probiotics from Brazilian Minas artisanal cheese and verify their
survival in frozen Brazilian cocoa pulp.

Methods:
Isolation and identification of the strains. The potential probiotic characterization involved
gastric juice and bile resistance, antibiotic and antimicrobial activity, hydrophobicity,
autoaggregation, coaggregation and adhesion assay in HT-29 cells. Organoleptic, viability and stability
of probiotic strain in frozen cocoa pulp were evaluated.

Results:
Fourteen strains of Lactobacillus plantarum (9), Weissella paramesenteroides (3), Lactobacillus
fermentum (1), and Leuconostoc mesenteroides (1) were obtained. Most of the strains were
resistant to simulated gastric acidity and bile salts. Almost all strains were sensitive to the antibiotics
tested, except to ciprofloxacin and vancomycin. About 47% of the strains are potential producers
of bacteriocins. High hydrophobicity was observed for four strains. Autoaggregation ranged
from 8.3-72.6% and the coaggregation capacity from 5.2-60.2%. All of the assessed strains presented
more than 90% of adhesion to HT-29 intestinal cells. The percentage of Salmonella inhibition
in HT-29 cells ranged from 4.7-31.1%. No changes in color, aroma, and pH were observed in
cocoa pulps after storage at -20 °C for 90 days.

Conclusion:
Wild strains of acid lactic bacteria from cheese proved to be viable and stable in frozen
Brazilian cocoa pulp. This work showed a promising application of L. plantarum isolated
strains to be used with frozen cocoa pulp matrix in probiotics food industry.
The effectiveness of teaching program of CIPP evaluation model
Authors: Darma I Ketut 
Published: April 2019

This study aimed at finding out the level of effectiveness of the implementation of the teaching at the Department of Mechanical Engineering Politeknik Negeri Bali (PNB) viewed from the interrelatedness of the components of context, input, process, and product, This study used the evaluative study model of CIPP (Context, Input, Process, Product) and was done in two stages. The data were collected using a questionnaire, interview guide, and related documents that have proved to be highly valid and reliable. The data were analyzed descriptive-qualitatively and descriptive-quantitatively. The result showed that the implementation of the teaching program at the Department of Mechanical Engineering PNB viewed from the interrelatedness of the components of CIPP falls into the fairly effective category. On the other hand, the constraints encountered in the teaching program implementation were faced in the components of context and product. The greatest constraints were found in the variables of process and product related to the evaluation of nonacademic learning achievement.
Interprofessional Learning for Enhanced Patient Safety: Biomedical Engineering Students and Nursing Students in Joint Learning Activities
Authors: Mattsson Janet , Ostlund Britt , Bjorling Gunilla , Williamsson Anna , Eriksson Andrea 
Published: April 2019

Background: In the last decade, research has highlighted the importance of interprofessional approaches to education and practice. Collaboration between medical practice and engineering has been identified as particularly relevant to developing accountable models for sustainable healthcare and overcoming increased specialization leading to professional barriers. This study aims to analyze insights and understanding expressed by nursing students and biomedical engineering students following a joint learning activity regarding a medical device used in the hospital setting.Method: A qualitative approach deriving from a phenomenological view examined an interprofessional learning activity where the focus was on active integration and knowledge exchange.Conclusion: The activity was expressed as a positive opportunity for getting insights into perspectives from other professional groups as well as insights into the importance of a system perspective in patient safety. The learning and insights listed in the evaluations included ideas about how the two professional groups could collaborate in the future.
Research progress on human microecology and infectious diseases
Authors: Bai Lu , He Wenlong 
Published: April 2019

AbstractHuman microecology has been extensively investigated. Similar to an important physiologically functioning organ of the human body, the microecological system is one of the leading systems for environmental survival, health, genetics, disease, and aging. It is also an essential carrier for drug metabolism and microbial resistance. The occurrence, development, and deterioration of many infectious diseases are closely related to human microecological systems. This study mainly focuses on the changes in microbial groups associated with various infectious diseases to explore the relevant role of human microecology in the development of infectious diseases and its breakthrough implications in future accurate treatments of infectious diseases.
PENGARUH LEVERAGE,FINANCIAL DISTRESS DAN GROWTH OPTIONS TERHADAP AKTIVITAS HEDGING PADA PERUSAHAAN NON-KEUANGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Nuzul Hafis , Lautania Maya Febrianty 
Published: April 2019

AbstractThis research aims to examine the influence of leverage, financial distress, and growth options on probability of the corporations to execute hedging activities using derivative instruments.The population of this research consist of non financial companies which are listed on IDX (Indonesia Stock Exchange) from 2012-2014.The samples of 210 companies were selected using slovin formula and simple random sampling technique. Hypothesis were tested utilizing logistic regression analysis.The results of this research show that leverage, financial distress, and growth options simultaneously influence the hedging activities by using derivative instruments. Partially leverage influence the hedging activities by using derivative instruments mean while financial distress and growth options do not influence hedging activities by using derivative instruments. Keywords: derivative instruments, financial distress, growth option, Hedging, leverage
PROFITABILITY, SOLVABILITY, PRICE EARNINGS RATIO AND PRICE TO BOOK RATIO AN EVIDENCE FROM INDONESIAN MANUFACTURING COMPANIES
Authors: Andarint Geubrina Ria 
Published: April 2019

Abstract This study aims atexamining the correlation of profitability ratio and solvability ratio, collectively and partially, on price earnings ratio and price to book ratio of manufacturing companies listed on the Indonesian stock Exchange. The data were obtained from the annual financial statement of the companied with the period of study wasbetween 2011 and 2013.A multiple regression analysis has been performed to analysesamples of 57 manufacturing companies that have been selected based on the purposive sampling. The results showed that the profitability has a positive and significant correlation on the price earnings ratio and price to book ratio of the companiesstudied. Meanwhile, the solvabilityhas a negative and significant effect on the price earnings ratio and price to book ratio. This study has also documented that theprofitability and solvability of the companies are better in explaining change of the Price to Book Ratio (PBR) than the Price Earnings Ratio (PER). Keywords: profitability ratio, solvability ratio, price earnings ratio, price to book ratio, Indonesia, Manufacturing Companies
Nilai Personal Dan Kesenjangan Anggaran - Sebuah Hubungan Kausalitas
Authors: Puspita Lisa Martiah Nila , Khoiriyah Rifaatul , Fuada Lukluk 
Published: April 2019

The study aimed to investigate individual values that involved in planning activities. This study tested the effect of three type of personal values (achievement, power, and tradition) on budgetary slack. This study used theory of planned behaviour. To determine the budgetary slack in this survey, 30 accounting students at Bengkulu University as respondents performed the specific task in December 2014. Firstly, they prepared a budget based on the real need, then the slack was created. Data was analysis by using multiple linear regression. The regression results indicated that the value of achievement and power values positively effected on budgetary slack. This meant that the higher the value of a person's achievement and power, the greater budgetary slack occurred. While the value of tradition negatively affected the budgetary slack, which means that the higher the value of tradition in the possession, the smaller the budgetary slack done. The limitation of this study was the measurement of the individual values obtained low result which indicated lack of correlation between the items in questionnaires. Therefore, the suggestion for future research is to improve or review the questionnaires that are used in this study.
Gender, Religiosity, Love of Money, and Ethical Perception of Tax Evasion
Authors: Dewanta Michael Ardho , Machmuddah Zaky 
Published: April 2019

ABSTRACTThis study aims to examine the effect of gender, religiosity, and love of money on ethical perception of tax evasion. The population of this study consist of undergraduate accounting students of private universities in Semarang,Central Java, Indonesia. Quota sampling method was utilized with total samples of 100 students. The data was collected using questionnaire and distribution period was three months from October-December 2017. Data analysis was performed using the Structural Equation Model (SEM) and Partial Least Squares (PLS) 3.0. The results of analysis showed that gender has no effect on religiosity and love of money. Meanwhile gender, religiosity, and love of money simultaneously affect the ethical perception of tax evasion. The results also unveil that love of money and religiosity cannot mediate the relationship between gender and ethical perception of tax evasion among undergraduate students. ABSTRAKPenelitian ini bertujuan untuk menguji pengaruh gender, religiusitas, dan kecintaan terhadap uang pada persepsi etis atas penggelapan pajak. Populasi penelitian ini terdiri dari mahasiswa sarjana akuntansi dari universitas swasta di Semarang, Jawa Tengah, Indonesia. Metode pengambilan sampel menggunakan metode quota sampling n dengan jumlah sampel 100 siswa. Data dikumpulkan dengan menggunakan kuesioner dan periode pengumpulan data adalah tiga bulan dari Oktober-Desember 2017. Analisis data dilakukan dengan menggunakan Structural Equation Model (SEM) dan Partial Least Squares (PLS) 3.0. Hasil analisis menunjukkan bahwa gender tidak berpengaruh pada religiusitas dan cinta uang. Sementara itu gender, religiusitas, dan cinta uang secara simultan mempengaruhi persepsi etika atas penggelapan pajak. Hasil penelitian juga menunjukkan bahwa kecintaan terhadap uang dan religiusitas tidak dapat memediasi hubungan antara gender dan persepsi etis penghindaran pajak di kalangan mahasiswa sarjana.
TELEMEDICAL TECHNOLOGIES IN SYSTEM OF THE EMERGENCY MEDICAL SERVICE
Authors: Parfyonov V. E. , Barsukova I. M. 
Published: April 2019

In the light of informatization of health care of the Russian Federation 2018 became a new stage of development of telemedical technologies in our country. The assessment of a current state of telemedical services in the Russian Federation was a research objective. The content analysis, legal, analytical methods are used. The telemedicine allows to make the state health care more effective and cheaper, considerably to optimize productions and logistics of the medical organizations, to provide increase in volumes of the rendered medical services. It is especially important within an emergency medical service when the distance and time are critical factors of assistance.
Developing an Amorphous Kerogen Molecular Model Based on Gas Adsorption Isotherms
Authors: Lee Hyeonseok , Ostadhassan Mehdi , liu kouqi , Bubach Bailey 
Published: April 2019

(1) Development of molecular models based on Bakken kerogen experiments using molecular dynamics and quantum mechanics software.(2) CO2 and N2 gas molecules adsorption simulation on the models was a good agreement with experiments.
Topology of Black Holes’ Horizons
Authors: Tozzi Arturo , Peters James F 
Published: April 2019

The Möbius strip spacetime topology and the entangled antipodal points on black hole surfaces, recently described by ‘t Hooft, display an unnoticed relationship with the Borsuk-Ulam theorem from algebraic topology. Considering this observation and other recent claims which suggest that quantum entanglement takes place on the antipodal points of a S3 hypersphere, a novel topological framework can be developed: a feature encompassed in an S2 unentangled state gives rise, when projected one dimension higher, to two entangled particles. This allows us to achieve a mathematical description of the holographic principle occurring in S2. Furthermore, our observations let us to hypothesize that a) quantum entanglement might occur in a four-dimensional spacetime, while disentanglement might be achieved on a motionless, three-dimensional manifold; b) a negative mass might exist on the surface of a black hole.
Improve the Performance of Advice Systems Based on Cooperative Liquidation Using Trust Relationships
Authors: Hriekes EEva Diab , AlAtassi Yosser AlSayed Souleiman 
Published: April 2019

Recommender systems are one of the recent inventions to deal with information overload problem and provide users with personalized recommendations that may be of their interests. Collaborative filtering is the most popular and widely used technique to build recommender systems and has been successfully employed in many applications. However, collaborative filtering suffers from several inherent issues that affect the recommendation accuracy such as: data sparsity and cold start problems caused by the lack of user ratings, so the recommendation results are often unsatisfactory. To address these problems, we propose a recommendation method called “MFGLT” that enhance the recommendation accuracy of collaborative filtering method using trust-based social networks by leveraging different user's situations (as a trustor and as a trustee) in these networks to model user preferences. Specifically, we propose model-based method that uses matrix factorization technique and exploit both local social context represented by modeling explicit user interactions and implicit user interactions with other users, and also the global social context represented by the user reputation in the whole social network for making recommendations. Experimental results based on real-world dataset demonstrate that our approach gives better performance than the other trust-aware recommendation approaches, in terms of prediction accuracy.
A Customized Non-Exclusive Clustering Algorithm for News Recommendation Systems
Authors: Darvishy Asghar , Ibrahim Hamidah , Sidi Fatimah , Mustapha Aida 
Published: April 2019

Clustering is one of the main tasks in machine learning and data mining and is being utilized in many applications including news recommendation systems. In this paper, we propose a new non-exclusive clustering algorithm named Ordered Clustering (OC) with the aim is to increase the accuracy of news recommendation for online users. The basis of OC is a new initialization technique that groups news items into clusters based on the highest similarities between news items to accommodate news nature in which a news item can belong to different categories. Hence, in OC, multiple memberships in clusters are allowed. An experiment is carried out using a real dataset which is collected from the news websites. The experimental results demonstrated that the OC outperforms the k-means algorithm with respect to Precision, Recall, and F1-Score.