bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prior Amiodarone Exposure Reduces Tacrolimus Dosing Requirements in Heart Transplant Recipients
Authors: Breslin Nadine T. , Salerno David M. , Topkara Veli K. , Latif Farhana , Restaino Susan , Takeda Koji , Takayama Hiroo , Farr Maryjane , Colombo Paolo C. , Jennings Douglas L. 
Published: March 2019

Introduction: Amiodarone use prior to heart transplant is independently associated with a higher rate of severe primary graft dysfunction and in-hospital mortality. Amiodarone may also alter the pharmacokinetics of medications metabolized via cytochrome P450. No data exist regarding the interaction between pretransplant amiodarone and tacrolimus concentrations. Design: Single-center retrospective study of transplant patients between January 1, 2014, and June 30, 2016. A therapeutic tacrolimus concentration was defined as a trough level between 8 and 15 ng/mL for 2 consecutive days. The primary outcome was the tacrolimus therapeutic weight-based dosing requirements (mg/kg/day) for patients receiving amiodarone prior to transplant when compared to those without prior receipt of amiodarone. Secondary outcomes include the incidence of cellular rejection and mortality within 6 months posttransplant. Results: Multi-organ transplant recipients (n = 3), retransplants (n = 9), those who died prior to a therapeutic level (n = 1), and those receiving amiodarone posttransplant (n = 7) were excluded from the analysis. Of the 80 patients included, 34 (42%) received amiodarone prior to transplant. Patient characteristics were similar, with the exception of primary graft dysfunction incidence (38% in amiodarone vs 8.5% in control, P = .001). The median therapeutic dose was 0.1 (interquartile range [IQR]: 0.07-0.12) versus 0.13 (IQR: 0.09-0.17) in the amiodarone and control groups, respectively, ( P < .01). No significant difference in mortality or rejection was noted. Conclusion: Patients receiving amiodarone prior to transplant require a lower weight-based dose of tacrolimus.
Use of a Targeted Exome Next-Generation Sequencing Panel Offers Therapeutic Opportunity and Clinical Benefit in a Subset of Patients With Advanced Cancers
Authors: Kopetz Scott , Mills Shaw Kenna R. , Lee J. Jack , Zhang Jiexin , Litzenburger Beate , Holla Vijaykumar , Kinyua Walter , Broaddus Emily , Daniels Molly S. , Meric-Bernstam Funda , Broaddus Russell R. 
Published: March 2019

PURPOSE Smaller hotspot-based next-generation sequencing (NGS) panels have emerged to support standard of care therapy for patients with cancer. When standard treatments fail, it is unknown whether additional testing using an expanded panel of genes provides any benefit. The purpose of this study was to determine if larger sequencing panels that capture additional actionable genes, coupled with decision support, translates into treatment with matched therapy after frontline therapy has failed. PATIENTS AND METHODS A prospective protocol accrued 521 patients with a wide variety of refractory cancers. NGS testing using a 46- or 50-gene hotspot assay, then a 409-gene whole-exome assay, was sequentially performed in a Clinical Laboratory Improvement Amendments–certified clinical laboratory. A decision-support team annotated somatic alterations in clinically actionable genes for function and facilitated therapeutic matching. Survival and the impact of matched therapy use were determined by Kaplan-Meier estimate, log-rank test, and Cox proportional hazards regression. RESULTS The larger NGS panel identified at least one alteration in an actionable gene not previously identified in the smaller sequencing panel in 214 (41%) of 521 of enrolled patients. After the application of decision support, 41% of the alterations in actionable genes were considered to affect the function of the gene and were deemed actionable. Forty patients (40 of 214 [19%]) were subsequently treated with matched therapy. Treatment with matched therapy was associated with significantly improved overall survival compared with treatment with nonmatched therapy ( P = .017). CONCLUSION Combining decision support with larger NGS panels that incorporate genes beyond those recommended in current treatment guidelines helped to identify patients who were eligible for matched therapy while improving overall treatment selection and survival. This survival benefit was restricted to a small subset of patients.
New Concepts About Familial Isolated Hyperparathyroidism
Authors: Marx Stephen J 
Published: March 2019

AbstractContextFamilial isolated hyperparathyroidism (FIHP) is defined as familial primary hyperparathyroidism (FH) without a characteristic extraparathyroidal feature of a more complex hyperparathyroid syndrome. New concepts of FIHP have been developed within this definition. FIHP has been difficult to study due to small kindreds and mildly symptomatic cases.Evidence AcquisitionSearches were through PubMed for FIHP, other FH syndromes, and the gene(s) mutated in each.Evidence SynthesisWithin its definition, the current concept of FIHP has clinical and mutational components that can include incomplete expressions of multiple endocrine neoplasia type 1 (MEN1) familial hypocalciuric hypercalcemia, hyperparathyroidism-jaw tumor syndromes, or their mutations. Newest concepts of FIHP focus on kindreds without mutation of the MEN1, CASR, or CDC73 genes; 17% have germline activating mutation of the gene for the GCM2 transcription factor. The FIHP kindreds with or without GCM2 mutation contain a median of only two cases of primary hyperparathyroidism. The small kindred size in both subgroups of FIHP is probably caused by a low rate of screening among relatives. Persons with FIHP and GCM2 mutation present as adults with mild hypercalcemia and multiple parathyroid tumors.ConclusionThe current concept of FIHP led to a focus on small kindreds without mutation of MEN1, CASR, or CDC73. These assisted in identifying germline activating GCM2 mutations in 17% of kindreds. Clinical and mutational characterization in more cases is needed to determine if there are any unique clinical features of FIHP, with or without mutation of GCM2.
D2 dopamine receptor activation induces female preference for male song in the monogamous zebra finch
Authors: Day Nancy F. , Saxon David , Robbins Anastasia , Harris Lily , Nee Emily , Shroff-Mehta Naomi , Stout Kaeley , Sun Julia , Lillie Natalie , Burns Mara , Korn Clio , Coleman Melissa J. 
Published: March 2019

ABSTRACTThe evolutionary conservation of neural mechanisms for forming and maintaining pair bonds is unclear. Oxytocin, vasopressin and dopamine (DA) transmitter systems have been shown to be important in pair-bond formation and maintenance in several vertebrate species. We examined the role of dopamine in formation of song preference in zebra finches, a monogamous bird. Male courtship song is an honest signal of sexual fitness; thus, we measured female song preference to evaluate the role of DA in mate selection and pair-bond formation, using an operant conditioning paradigm. We found that DA acting through the D2 receptor, but not the D1 receptor, can induce a song preference in unpaired female finches and that blocking the D2 receptor abolished song preference in paired females. These results suggest that similar neural mechanisms for pair-bond formation are evolutionarily conserved in rodents and birds.
Can a workshop increase pregnant women's knowledge of their birthplace options?
Authors: Murphy Breda , Wong Sandy 
Published: March 2019

Background Research shows that women consistently report a lack of adequate, unbiased information about their birthplace choices. Aim One midwfery unit aimed to address the issue by creating a workshop to disseminate the findings of Brocklehurst et al's (2011) birthplace study and report local data. Method Standards were set at 70% of suitable women being booked to attend. It was aimed that 100% of those women would actually attend, and that 100% would report receiving appropriate and sufficient information. Findings Overall, 45.7% of eligible women were booked to attend and 77.7% of those booked did attend. All women who attended reported having received adequate information. The number of birth centre births in the area rose by 31.3% after the implementation of the workshop. Conclusion Although attendance could be improved, the authors were confident that the workshop is a positive step in increasing women's knowledge of their birthplace options. Local initiatives must be commended; however, strategies must be implemented on a national level to alter the status quo of hospital births as the safest option for all women.
Colonial hauntings in Lynda Barry’s One Hundred Demons
Authors: Oh Stella 
Published: March 2019

Abstract
This article traces two interrelated affective economies present in Lynda Barry’s One Hundred Demons. First, I begin with a discussion of colonial hauntings demonstrated by the numerous demons in Barry’s text whose title also bears this word. The demons of Barry’s text are ghostly presences that are the aftereffects of colonial trauma. Second, I examine the ways in which Barry employs what I call are ‘sticky visual rhythms’ that produce haptic knowledge that reverberates colonial hauntings of racism, sexism and empire. These affective rhythms not only echo the haunting effects of colonization, empire and intimacies, but also offer new ways of countering patriarchal and imperial desires. The ‘sticky visual rhythms’ of One Hundred Demons allow us to think through issues of self-loathing, anger and depression that disproportionately affect those who have been subjected to traumas of colonialism and other structural inequalities.
Focalized split panels: Bridging the borders in comics form
Authors: Poharec Lauranne 
Published: March 2019

Abstract
Although comics scholars have examined split panels, also known as polyptychs, as a visual strategy that transforms space into time, this article establishes that split panels can also cue focalization. The first part of this article reviews current theories about sequentiality and segmentivity in comics in order to establish some of the ways in which split panels can question, or complicate, generally agreed-upon understandings of comics’ sequences in terms of time and space. The second part of this article consists in close visual analyses of several split panels taken from Craig Thompson’s Good-Bye Chunky Rice (1999), Alex Robinson’s Tricked (2010), Mawil’s Wir Können Ja Freunde Bleiben (2003, published in English in 2008 as We Can Still Be Friends) and Glyn Dillon’s The Nao of Brown (2012). This article draws from Silke Horstkotte and Nancy Pedri’s theory of focalization in comics, as well as Jan Baeten’s distinction between the suturing and individualizing function of the gutter, to argue that split panels can represent characters or narrators’ subjective experiences that inform the processing of the story by readers. They can, for instance, represent through visual means a character’s fragmented, troubled mind or hint at the likes and dislikes between characters across the gutter. This article thus demonstrates that the use of split panels is a rich visual strategy whose complex narrative function derives from the suturing or individualizing role of the gutter. Weaving together panels with gutters that at once distinguish and highlight elements of a visually coherent image, split panels allow for a meaningful experimentation with panel size, shape and position that often enhances the mental workings of the focalizing agent.
Convergências e Divergências Epistemológicas no Hibridismo entre a Sociolinguística e o Funcionalismo / Epistemological Convergences and Differences in Hybridism between Sociolinguistics and Functionalism
Authors: Santos Amorim Vania Raquel , Sousa Valéria Viana 
Published: March 2019

Resumo: A Sociolinguística e o Funcionalismo constituem teorias que se unem por reconhecerem a heterogeneidade da língua e por priorizarem seu uso real como ponto basilar para explicar processos de variação e mudança. A interface entre essas teorias e a articulação dos seus princípios são estudadas por alguns pesquisadores com a denominação de Sociofuncionalismo. Neste trabalho, apresentamos as confluências e divergências na interface dessas teorias, mostrando que esse hibridismo é capaz de trazer grandes contribuições para descrição e análise da linguagem a partir dos pontos afins de suas epistemologias, como também, através da constituição de um diálogo entre as diferenças existentes entre alguns de seus conceitos aparentemente incompatíveis.
O aporte da genética na calvície masculina: uma revisão de literatura / The Genetic Contribution in Male Pattern Baldness: A Literature Review
Authors: Feitosa Pedro Walisson Gomes , Damasceno Irving Araújo , Alcântara Izabela Pinho de , Ferreira Clarice Maria De Moraes , Pinheiro Sally De França Lacerda 
Published: March 2019

A calvície é um caráter hereditário complexo e a forma mais comum de perda de cabelo em humanos, acometendo cerca de 50% da população masculina com idade de 50 anos. Apesar de ser amplamente aceita a opinião de que a calvície é um fenótipo autossômico dominante em homens e autossômico recessivo em mulheres, há uma grande suspeita de uma herança poligênica. O objetivo deste trabalho é identificar a relação da hereditariedade na calvície, além de identificar (troca o 1o identificar por conhecer ou compreender) genes candidatos para desencadeá-la. A pesquisa foi realizada a partir de uma revisão sistemática da literatura no período de 01.01.2008 até 30.06.2018 na base de dados do PubMed. Foram utilizados os seguintes descritores: “male pattern baldness” e “genetic”. Foram encontrados 53 artigos na busca eletrônica, sendo 10 selecionados na amostra final do estudo. Os genes identificados se encontram principalmente nos cromossomos X e 20 em determinados loci. O gene Receptor de Andrógenos (AR) é o mais estudado, além de seu upstream (EDA2R) e downstream (OPHN1), enquanto também foram descritos e estudados polimorfismos através de GWAS, e detectados os mais característicos, como o rs12565725, no cromossomo 1, rs929626 no cromossomo 5 e o rs756853 no cromossomo 7; além do locus cromossômico 20p11. Outros genes foram relacionados também, como o EBF1 e o HDAC9. Entretanto, os estudos apresentados não se mostram conclusivos e reforçam que análises mais aprofundadas são necessárias.
Dependências de Substâncias Psicoativas: Um Estudo sobre a Representação Social do Dependente e do Tratamento / Dependencies of Psychoactive Substances: A Study on the Social Representation of Dependent and Treatment
Authors: Oliveira Aislan José , Ferro Luiz Roberto Marquezi , Rosa Diego Gantes , Rezende Manuel Morgado , Watanabe Adriano Luís Alves 
Published: March 2019

Introdução: A busca de entendimento sobre os processos da saúde e do adoecer é uma história de construções de significados sobre a natureza, as funções e a estrutura do corpo e ainda sobre as relações corpo-espírito e pessoa-ambiente. Essas significações têm sido “transformadas” ao longo dos tempos, constituindo diferentes representações na cultura, bem como aspectos sociais, políticos, religiosos e científicos dentre outros. Objetivos: O presente trabalho visa uma revisão histórica da literatura objetivando entender inicialmente como se construiu a representação social do dependente químico e posteriormente como isso influencia na propostas de intervenções no âmbito do tratamento. Método: Trata-se de uma pesquisa qualitativa, descritiva, exploratória e de revisão bibliográfica. Foram consultadas as bases de dados: Scielo, Pepsic, LILACS e BVS considerando publicações que abordassem de forma os objetivos desta pesquisa. Resultados: Foram selecionados 27 referências bibliográficas que ajudaram a responder aos objetivos desta pesquisa. Discussão: Foi possível perceber que a forma de pensar e entender a origem e evolução das dependências de substâncias psicoativas transitam entre as esferas biológica, psicológica e social até uma origem pecaminosa e de criminalidade e que historicamente duas áreas disputam a hegemonia no campo das dependências de substâncias psicoativas: a Medicina e a justiça. Conclusões: O entendimento sobre das intervenções a dependência de substâncias psicoativas no Brasil inicialmente não foram entendidas como problema de saúde e sim como um problema de segurança pública e tiveram por muitas décadas todas suas estratégias de ação voltadas a esse foco, sendo então carregadas e permeadas de interpretações morais, legais e posteriormente médicas, sugerindo as origens de algumas incoerências encontradas nas políticas públicas do tema na atualidade.
Politicamente Correto: Análise do Sentido de Pessoa com Deficiência em Matéria do Jornal O Globo / Politically Correct: Analysis of the Meaning of the Person with Disabilities in an article of Jornal O Globo
Authors: Leal Raísa Ribeiro , Ventura Adilson 
Published: March 2019

Esse trabalho é um recorte da dissertação de mestrado intitulada “O sentido de pessoa com deficiência em jornais de grande circulação em comparação ao Estatuto da Pessoa com Deficiência”. Neste artigo,apontamos a desconstrução do politicamente correto através de mecanismo de análise da Semântica do Acontecimento. Para tanto, são desenvolvidas análises de determinados enunciados a fim de demonstrar que o sentido não é fixo e como essa análise dos sentidos pode contribuir para uma ação que aqui denominamos Ética.
Youth solidarities in graffiti tourism
Authors: Kuzovenkova Yuliya A. 
Published: March 2019

The study was performed using the solidarity approach proposed by E. L. Omelchenko. The term "solidarity" is convenient to study the contemporary developments in youth culture as it does not require a direct interaction of subjects, the unity of time and space in which they act. The aim of the work is to study the features of solidarity formation among street artists in graffiti tourism. The empirical material is the case study of Samara street artist Art Abstractov, who has many years of experience in graffiti tourism.
The author identifies two stages in the organization and implementation of graffiti tourism: on-line and off-line stages. Considering the first stage, the author describes the role of electronic resources in the development of the street art culture: blog electronic databases, specialized sites such as Art Crimes, 149 St., graffiti.org, Ekosystem, ViVaCity.ru, Petrograff.ru, Vltramarine, social networks such as Livejournal, VKontakte, Facebook, Instagram, Tumblr, image hosting sites such as Flickr, Pinterest, etc. The paper examines the specifics of social networking among street artists at the international level and the nature of solidarity in the virtual space between the street artists not personally known to each other.
The second stage of graffiti tourism is considered as a form of consolidation of solidarities among street artists from different countries. The author describes the role of the host and the benefits that the tourist gets from such trips. The author comes to the conclusion that solidarity is transformed into other forms of social communities over time and helps to enter a new social environment.
An early Byzantine Pseudepigraphon: the Apocryphal Acta Barnabae
Authors: Cairns Francis 
Published: March 2019

Abstract
This paper treats the fifth-century AD apocryphal Acta Barnabae (= ABarn). § I sets out briefly the consensus view of ABarn’s main aim - to establish the autocephaly of the Cypriot Church by endowing it with an apostolic founder, Barnabas, in a text modelled on Acts which affects to be contemporary with Acts and to be the work of John Mark. § II examines ABarn’s detailed interactions with Acts, its foregrounding of Barnabas over Paul, and its centralising of Cyprus in early Christianity; ‘itinerary style’ is highlighted as a prominent feature of ABarn’s striving for verisimilitude. § III treats ABarn’s use of further ‘novelistic’ strategies for the same purpose; they mostly draw on topoi, but sometimes arguably on personal knowledge of Cyprus. § IV reflects on ABarn’s curious downgrading of its inscribed author, John Mark. This is attributed to the anti-Monophysite stance of the fifth-century (Orthodox) Cypriot Church towards both the Antiochene and Alexandrian Patriarchates.
Quench Cooling Performance–Hardness Correlation for AISI 1045 and 1090 Steels
Authors: Nayak U. V. , Prabhu K. N. 
Published: March 2019

Abstract
Heat transfer and microstructure evolution during quenching of AISI 1045 and 1090 steels in vegetable oils was investigated. To simulate the industrial quench heat treatment, reference probes made of medium and high carbon steels were quenched, and heat flux transients were estimated by taking into account the phase transformation. The cooling curves obtained with reference probes made from AISI 1045 and AISI 1090 steels showed kinks indicating enthalpy change accompanied with phase transformations during continuous cooling. This was reflected in the estimated heat flux curves. The section thickness effect on heat flux transients was examined by using probes of diameters 25 mm and 50 mm. The cooling rates measured at various locations across the section diameter of reference probes were related to the hardness using the quench factor technique. The heat transfer characteristics of the quench media, the evolved microstructure, and the resulting hardness were in complete agreement.
Aproximación a las prácticas ciudadanas en la escuela: el caso del colegio Fernando González Ochoa de la localidad de Usme (Bogotá, Colombia)
Authors: Gómez Rodrigo 
Published: March 2019

En el presente estudio se hace una aproximación a la comprensión de las prácticas ciudadanas escolares de los estudiantes de noveno grado jornada tarde del colegio Fernando González Ochoa, ubicado en la localidad quinta de Bogotá (Colombia). Metodológicamente se fundamenta en un estudio cualitativo con enfoque hermenéutico-interpretativo, a través de observación participante, entrevistas semiestructuradas y grupos focales. Se identifican como principales dimensiones de las prácticas ciudadanas escolares: la participación, la convivencia, el sentido de pertenencia, la identidad, el reconocimiento de sí mismo y de los otros, los derechos y las responsabilidades dentro de lo que implica ser joven hoy en el contexto social, cultural, político, económico y educativo del sector de Usme, así como de sectores vulnerables de la ciudad. Esta población juvenil en contexto escolar actúa de acuerdo con su realidad inmediata siendo permeados por los medios de comunicación, además de la familia y sus pares, que les permite establecer nuevas formas de interacción, que los diferencia de los adultos y son una muestra de las nuevas maneras de interrelación, comunicación y de participación ciudadana.