bluuebunny/crossref_metadata_2025_split huggingface dataset:
Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells
Authors: Yan Xu , Yu Yu , Li Lingyu , Chen Naifei , Song Wei , He Hua , Dong Jie , Liu Xiangliang , Cui Jiuwei 
Published: June 2018

AbstractBreast cancer is the most common cancer in women worldwide; despite the developments in diagnosis and therapy, recurrence and metastasis remain the main causes of death among patients with breast cancer. This study aimed to identify a promising biomarker for this disease. The study clarified (1) the association between Friend leukemia virus integration 1 (FLI‐1) and various molecular subtypes and (2) the prognostic value of FLI‐1 in breast cancer. To the best of our knowledge, this study is the first to report that FLI‐1 is a predictor of poor prognosis in patients with breast cancer and overexpressed in the triple negative breast cancer (TNBC) subtype. To further verify the effect of FLI‐1 in promoting the metastasis of TNBC, we performed a series of functional experiments in vitro and orthotopic xenograft experiments in the mammary fat pad of nude mice. FLI‐1, as a transcription factor, bound to the promoters of key EMT‐related genes (CDH1 and VIM), and regulated their expressions at the transcriptional level, thus induced epithelial‐mesenchymal transition (EMT). The overexpression of FLI‐1 significantly upregulated the expression of mesenchymal markers. After the modulation of FLI‐1, the changes in mammary stem cell markers (ALDH1A1 and CD133) and the capacity to form mammospheres were consistent with those of the EMT‐related markers. The orthotopic xenograft models further confirmed that the attenuation of stem cell traits after silencing FLI‐1 decreased the ability of tumorigenesis. These results indicate that FLI‐1 is a useful predictor of poor prognosis in patients with breast cancer. Furthermore, the preliminary exploration of metastatic mechanism in the patients with TNBC will provide a potential target to treat breast cancer in the near future.
Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria
Authors: Vieira Tatiana M. , dos Santos Isabella A. , Silva Thayná S. , Martins Carlos H. G. , Crotti Antônio E. M. 
Published: June 2018

We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC = 50 μg/ml) and Streptococcus mitis (MIC = 50 μg/ml) as well as moderate activity against S. sanguinis (MIC = 100 μg/ml), Lactobacillus casei (MIC = 100 μg/ml), and Streptococcus salivarius (MIC = 200 μg/ml). Results indicated higher activity of compound 10 than that of its bis‐β‐diketone analog. Additionally, compounds 3a (1,5‐bis(4‐methylphenyl)pentan‐3‐one) and 7b (1,5‐bis(4‐bromophenyl)pentan‐3‐ol) were moderately active against S. mitis (MIC = 100 μg/ml) and S. salivarus (MIC = 200 μg/ml).
Cor triatriatum sinistrum in a pregnant woman
Authors: Zhiva Taherpour 
Published: June 2018

Key Clinical MessageCor triatriatum sinistrum is a congenital cardiac malformation in which left atrium is divided into 2 parts by a perforated fibromuscular membrane, it can mimic signs and symptoms of mitral valve (MV) stenosis or occasionally without any symptoms and discovered as an accidental finding.
Prolonged third complete remission after busulfan, thiotepa, and autologous stem cell transplant in a primary central nervous system lymphoma patient
Authors: Camus Vincent , Dubois Sydney , Lepretre Stéphane , Jardin Fabrice , Tilly Hervé 
Published: June 2018

Key clinical messagePrimary central nervous system lymphoma (PCNSL) remains a therapeutic challenge due to impaired drugs diffusion as a result of the blood‐brain barrier and high risk of relapse. Patients with good performance status, chemo‐sensitive disease, and eligible for autologous stem cell transplant (ASCT) may benefit from salvage therapy and therapeutic intensification that may allow long‐term remission.
Ultrafine SnO2 Nanocrystals Self‐Anchored in Carbon for Stable Lithium Storage
Authors: Fu Shuting , Wu Qili , He Shiman , Tong Shengfu , Yang Xianfeng , Meng Yuying , Wu Mingmei 
Published: June 2018

AbstractSn‐based materials can be potentially used as anode in lithium‐ion batteries (LIBs), though challenges still exist. Herein, SnO2/C composites with ultrafine SnO2 nanocrystals uniformly anchored to the carbon matrix are simply synthesized via a one‐pot solvothermal method. In this structure, the nano‐sized SnO2 can offer abundant electroactive sites and effectively shorten the lithium‐ion diffusion length. The interfacial structure between SnO2 and the carbon matrix restricts the particle within a specific space, allowing elastic buffering and alleviating the agglomeration and pulverization. Therefore, the capacity decay due to volume variation upon cycling can be refrained remarkably. Moreover, the unique interfaces facilitate electron transfer, as well as additional lithium storage (i. e., pseudocapacitance). Benefiting from these unique architectural merits, our optimized SnO2/C composite exhibits high specific capacity (600 mAh g−1 at 0.2 A g−1) and superior rate capability (185 mAh g−1 at 11.7 A g−1) when applied to LIBs anodes. Even without an additional conductive agent, the electrode can maintain its extremely stable performance. The strategy proposed here proves the feasibility to enhance electrochemical properties, utilizing the synergetic effect between SnO2 nanocrystals and the carbon base. Thus, the optimized SnO2/C is a promising candidate for applications as anode material in LIBs.
A review of orthogonal projections for calibration
Authors: Roger Jean‐Michel , Boulet Jean‐Claude 
Published: June 2018

AbstractEffective methods often rely on simple mathematical operators. Among these operators, orthogonal projections have been widely used because of their simplicity in compensating for detrimental factors. This efficiency depends largely on the way these tools are prepared. This article links the mathematical basics of orthogonal projections to the notion of vectoral subspaces, highlighting which information should be removed in the process and the important practical properties concerned with optimizing this technique. This review covers several methods involving orthogonal projections and focuses specifically on their practical use. This concerns the identification of detrimental information and its removal together with adjusting the dimension of the projection. The methodology discussed in this review will enable the reader to optimize orthogonal projections for any given situation.
Multimode complex process monitoring using double‐level local information based local outlier factor method
Authors: Wang Lei , Deng Xiaogang , Cao Yuping 
Published: June 2018

AbstractIndustrial processes typically have multiple operating modes with complex data distribution and locality faults, which challenges the traditional multivariate statistical process monitoring methods. To address this problem, a double‐level local information‐based local outlier factor (LOF) method is proposed in this work for multimode complex process monitoring. First, to handle the multimodality, the local neighborhood standardization strategy is adopted to utilize the statistical information of local data structure. Second, the variable LOF method is proposed to determine reasonable boundary for complex data distribution and simultaneously reflect local variable behaviors. For better online monitoring, a weighting strategy is applied to emphasize the local variable information, and the Bayesian inference is employed to integrate the LOF value of each variable. To isolate the fault variables, a contribution plot is designed. Finally, a numerical example and the benchmark Tennessee Eastman process are used to demonstrate the effectiveness and superiority of the proposed method.
Linear CuI2Pd0, CuIPd02, and AgI2Pd0 Metal Chains Supported by Rigid N,N′‐Diphosphanyl N‐Heterocyclic Carbene Ligands and Metallophilic Interactions
Authors: Ai Pengfei , Monakhov Kirill Yu. , van Leusen Jan , Kögerler Paul , Gourlaouen Christophe , Tromp Moniek , Welter Richard , Danopoulos Andreas A. , Braunstein Pierre 
Published: June 2018

AbstractSelective copper(I) to palladium(0) transmetallation of P‐donors from the rigid N,N′‐diphosphanyl‐imidazol‐2‐ylidene C3H2[NP(tBu)2]2 (PCNHCP) was observed when known [Cu3(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)3 was reacted with [Pd(PPh3)4]. When 1.2 equivalents of [Pd(PPh3)4] was used, the product [Cu2Pd(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)2 (2(OTf)2) was obtained, which features a CuI–CuI–Pd0 chain and appears to be the first linear heterotrinuclear complex with d10–d10 interactions between Pd0 and CuI. When the Cu3 precursor was reacted with 3.0 equivalents of [Pd(PPh3)4], the complex [CuPd2(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)2 (3(OTf)2) was obtained, which, on the basis of magnetic measurements, DFT calculations, and computed nuclear shieldings, was formulated as containing a Pd0–CuI–Pd0 chain with an electron hole delocalized over the whole cation, including the metal chain. Similarly, selective transmetallation of the P‐donors in [Ag3(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)3 from silver to palladium (originating from [Pd(PPh3)4]) gave the linear chain [Ag2Pd(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)2 (5(OTf)2), which on the basis of NMR spectroscopy comprises an AgI–AgI–Pd0 metal core. However, X‐ray diffraction data collected on various samples of 5(OTf)2 were modeled with 50:50 metal disorder at the terminal positions, corresponding to a (AgI/Pd0)–AgI–(AgI/Pd0) formulation. Upon standing in solution, 5(OTf)2 transformed to 6(OTf)2, the regioisomer of 5(OTf)2 in which the Pd center has migrated to the central position of an AgI–Pd0–AgI chain. Prolonged standing in CH2Cl2 or by reaction with [PtCl2(NCMe)2] converts complex 6(OTf)2 to the AgI/PdII complex [Ag2PdCl2(μ3‐PCNHCP,κP,κCNHC,κP)2](OTf)2 (7(OTf)2). The structural data of 2(OTf)2, 3(OTf)2, and 7(OTf)2 establish significant heterometallophilic interactions.
Solvent‐ and Halide‐Induced (Inter)conversion between Iron(II)‐Disulfide and Iron(III)‐Thiolate Complexes
Authors: Wang Lianke , Cantú Reinhard Fabián G. , Philouze Christian , Demeshko Serhiy , de Visser Sam P. , Meyer Franc , Gennari Marcello , Duboc Carole 
Published: June 2018

AbstractDisulfide/thiolate interconversion controlled by Cu is proposed to be involved in relevant biological processes. In analogy to Cu, it can be envisaged that Fe also participates in the control of similar biological processes. We describe here Fe complexes that undergo FeIII‐thiolate/FeII‐disulfide (inter)conversion mediated by halide (de)coordination, and by the nature of the solvent. The dinuclear FeII‐disulfide complex [FeII2(LSSL)]2+ ((LS)2−=2,2′‐(2,2′‐bipyridine‐6,6′‐diyl)bis(1,1‐diphenylethanethiolate), (LSSL)2−=the corresponding disulfide ligand) shows solvent‐dependent properties. Whereas in a non‐coordinating solvent (CH2Cl2) the dinuclear FeII‐disulfide complex is the only stable form, in the presence of coordinating solvents like MeCN or DMF it is partly or fully converted into mononuclear FeIII‐thiolate species having a bound solvent molecule ([FeIII(LS)(Solv)]+, Solv=DMF, MeCN). Addition of Cl− to a CH2Cl2 solution containing the FeII‐disulfide dinuclear complex leads to the fast and quantitative formation of a mononuclear FeIII‐thiolate species with a bound Cl−, that is, ([FeIII(LS)Cl]). The reverse reaction can be achieved by addition of Li[[B(C6F5)4]. In relation to the metal–sulfur electronic distribution, the comparison between the redox properties of the Fe, Mn and Co complexes involved in these MIII‐thiolate/MII‐disulfide interconversion processes allow one to rationalize their respective efficiency.
Highly Stable and Red‐Emitting Nanovesicles Incorporating Lipophilic Diketopyrrolopyrroles for Cell Imaging
Authors: Ardizzone Antonio , Blasi Davide , Vona Danilo , Rosspeintner Arnulf , Punzi Angela , Altamura Emiliano , Grimaldi Natascia , Sala Santi , Vauthey Eric , Farinola Gianluca M. , Ratera Imma , Ventosa Nora , Veciana Jaume 
Published: June 2018

AbstractDiketopyrrolopyrroles (DPPs) have recently attracted much interest as very bright and photostable red‐emitting molecules. However, their tendency to form nonfluorescent aggregates in water through the aggregation‐caused quenching (ACQ) effect is a major issue that limits their application under the microscope. Herein, two DPP molecules have been incorporated into the membrane of highly stable and water‐soluble quatsomes (QS; nanovesicles composed of surfactants and sterols), which allow their nanostructuration in water and, at the same time, limits the ACQ effect. The obtained fluorescent organic nanoparticles showed superior structural homogeneity, along with long‐term colloidal and optical stability. A thorough one‐ (1P) and two‐photon (2P) fluorescence characterization revealed the promising photophysical features of these fluorescent nanovesicles, which showed a high 1P and 2P brightness. Finally, the fluorescent QSs were used for the in vitro bioimaging of Saos‐2 osteosarcoma cell lines; this demonstrates their potential as nanomaterials for bioimaging applications.
A Conductive Ni2P Nanoporous Composite with a 3D Structure Derived from a Metal–Organic Framework for Lithium–Sulfur Batteries
Authors: Cheng Junhan , Zhao Dan , Fan Lishuang , Wu Xian , Wang Maoxu , Wu Hexian , Guan Bin , Zhang Naiqing , Sun Kening 
Published: June 2018

AbstractSulfur cathodes have attracted significant attention as next‐generation electrode material candidates due to their considerable theoretical energy density. The main challenge in developing long‐life Li–S batteries is to simultaneously suppress the shuttle effect and high areal mass loading of sulfur required for practical applications. To solve this problem, we have designed a novel nickel phosphide nanoporous composite derived from metal–organic frameworks (MOFs) as sulfur host materials. Homogeneous distribution of Ni2P nanoparticles significantly avoids soluble polysulfides migrating out of the framework through strong chemical interactions, and the conductive 3D skeleton offers an accelerating electron transport. As a result, S@Ni2P/NC has exhibited an enhanced performance of 1357 mAh g−1 initially at 0.2 C (1 C=1675 mA g−1) and remaining at 946 mAh g−1 after 300 cycles. Even at an areal mass loading of sulfur as high as 4.6 mg cm−2, the electrode still showed an excellent specific capacity of 918 mAh g−1.
Phase‐Controlled Synthesis of Nickel Phosphide Nanocrystals and Their Electrocatalytic Performance for the Hydrogen Evolution Reaction
Authors: Li Huiming , Lu Siqi , Sun Jingyao , Pei Jiajing , Liu Di , Xue Yanrong , Mao Junjie , Zhu Wei , Zhuang Zhongbin 
Published: June 2018

AbstractThe phase of nanocrystals has a key role in the modulation of catalytic properties. Uniform and well‐crystallized nickel phosphide nanocrystals with controlled phases (Ni5P4, Ni2P, and Ni12P5) and narrow size distributions are synthesized by a wet chemical method. The phases of the as‐synthesized nickel phosphide nanocrystals are controlled by the P/Ni precursor molar ratio, heating process, and time of reaction. Rarely reported nearly monodisperse 5.6 nm Ni5P4 nanocrystals are successfully synthesized and show superior hydrogen evolution reaction (HER) activity. Only a low overpotential of 103 mV is required to achieve the HER current of 10 mA cm−2 at a low catalyst loading of 0.12 mg cm−2. The high HER activity is attributed to the high quality of the as‐obtained Ni5P4 nanocrystals, which have the electronic effect from the Ni5P4 phase and also high surface area owing to the small particle size. A systematic study of the controlled synthesis of nickel phosphide nanocrystals is shown in this paper, and the HER catalytic activity is improved through the phase‐ and size‐controlled synthesis of nanocrystals.
Exploring Fe‐Nx for Peroxide Reduction: Template‐Free Synthesis of Fe‐Nx Traumatized Mesoporous Carbon Nanotubes as an ORR Catalyst in Acidic and Alkaline Solutions
Authors: Shah Syed Shoaib Ahmad , Najam Tayyaba , Cheng Chao , Peng Lishan , Xiang Rui , Zhang Ling , Deng Jianghai , Ding Wei , Wei Zidong 
Published: June 2018

AbstractFe‐based electrocatalysts are elegant due to their better performance towards the oxygen reduction reaction. Nevertheless, they commonly contain different moieties, for example Fe‐Nx, Fe, Fe3C and N‐doped carbon, primarily the debatable assistance of these components towards ORR electrocatalysis, specifically for intermediate peroxide reduction reactions (PRR). In this paper, to explore the role of Fe‐Nx centres for PRR, a Fe‐N‐C electrocatalyst rooted in nitrogen‐doped carbon nanotubes with mesoporous structures was synthesized from a Fe/Zn‐dicyanoimidazolate framework. The use of dicyanoimidazole coordinated with iron can introduce the Fe‐Nx active sites as well as directional N‐doped carbon nanotubes, which is good for enhancing electronic conductance of the catalyst. The attained electrocatalyst shows tremendous enactment to ORR, being comparable to the activity of Pt/C in acidic and better in alkaline electrolytes. This study also reveals that Fe‐Nx active centres are responsible for less H2O2 production. Though the Fe‐Nx moieties and Fe3C/Fe particles encapsulated N‐doped carbon, both are active centres for ORR, however, Fe‐Nx sites are more active than others for peroxide reduction reaction. These perceptions suggest rational methodologies for more active and consequently further durable Fe‐N‐C catalysts.
Multiparameter Characterization of Aerosols
Authors: Babick Frank , Hillemann Lars , Stintz Michael , Dillenburger Tim , Pitz Michael , Hellmann Albert , Antonyuk Sergiy , Ripperger Siegfried , Huber Franz J. T. , Will Stefan , Wernet Ruth , Seipenbusch Martin , Gensch Manuel , Weber Alfred , Kiesler Dennis , Kruis Einar , Friehmelt Rainer , Sachweh Bernd 
Published: June 2018

AbstractThe performance of particle‐based products depends on a multiple set of particle properties. To monitor them during particle manufacturing, three novel aerosol measurement techniques were developed: wide‐angle light scattering (WALS), three‐dimensional laser scattering (3D‐LSS), and differential aerodynamic particle sizing (DAPS). They measure particle shape, aggregate structure, and particle size, i.e., radius of gyration and aerodynamic diameter. The techniques were tested for rod‐like organic pigments and partially sintered SiO2 aggregates, which were produced by two new aerosol generators.
A Measure and Model of Psychological Health and Safety in the Workplace that Reflects Canada's National Standard
Authors: Ivey Gary W. , Blanc J.‐R. Sébastien , Michaud Kathy , Dobreva‐Martinova Tzvetanka 
Published: June 2018

AbstractTo monitor workplace factors associated with well‐being and performance in the Department of National Defence, and embodying departmental efforts to create and maintain a healthy workplace, we assembled a comprehensive and psychometrically sound survey battery that reflects Canada's national standard for psychological health and safety. Moreover, for testing and understanding the relationships among the survey variables and national standard factors, we applied an evidence‐based framework to build a conceptual psychological health and safety model. In this article, we introduce our survey and model to other organizations and the wider academic community, we provide some preliminary support for the pattern of results illustrated in our climate profiles, and we discuss our future research agenda to address current limitations. © 2018 Her Majesty the Queen in Right of Canada. Canadian Journal of Administrative Sciences © 2018 ASAC. Published by John Wiley & Sons, Ltd. Reproduced with the permission of the Minister of National Defence.
Removal of elemental mercury by Ce and Co modified MCM‐41 catalyst from simulated flue gas
Authors: Zhang Xiaopeng , Tan Bojian , Wang Jinxin , Zhang Hang , Li Chengfeng , He Gaohong 
Published: June 2018

AbstractCo and Ce based catalysts have been proven to possess a high Hg0 removal efficiency. However, these catalysts have a low dispersion of active components and low mass transfer rate, which limits their catalytic activity. MCM‐41 has a large surface area and a highly ordered mesoporous structure, which can improve the dispersion of Co and Ce, resulting in a high mass transfer rate. In this paper, different amounts of Co and Ce were loaded on MCM‐41 to synthesize Cox‐Cex/MCM‐41. The characteristic results of the catalyst showed that catalysts with a lower Co and Ce loading amount had a high dispersion and a low crystallinity, leading to more activity sites on the catalyst surface. Hence, the Hg0 removal efficiency of the catalysts first increased with the increase of the Co and Ce loading amount. However, with the further increase of the Co and Ce loading amount, the crystallinity of the catalysts increased, which might cause the blockage of the pores and the decrease of BET surface areas, leading to a low Hg0 removal efficiency. Along with the factors mentioned above, Co0.15‐Ce0.15/MCM‐41 had the best catalytic activity, which showed above 85 % Hg0 removal efficiency in the temperature range of 200–300 °C at 180 000 h−1. Flue gas components had different effects on catalytic activity. O2 and NO could promote, but H2O and SO2 inhibit the Hg0 removal efficiency. The simulated flue gas of 300 ppm SO2, 400 ppm NO, 6 % H2O, and 5 % O2 have serious effects on catalytic activity leading to a lower Hg0 removal efficiency of 20 % for Co0.15‐Ce0.15/MCM‐4.
Structure–Activity Relationship Studies on (R)‐PFI‐2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
Authors: Lenstra Danny C. , Damen Eddy , Leenders Ruben G. G. , Blaauw Richard H. , Rutjes Floris P. J. T. , Wegert Anita , Mecinović Jasmin 
Published: June 2018

AbstractSETD7 is a histone H3K4 lysine methyltransferase involved in human gene regulation. Aberrant expression of SETD7 has been associated with various diseases, including cancer. Therefore, SETD7 is considered a good target for the development of new epigenetic drugs. To date, few selective small‐molecule inhibitors have been reported that target SETD7, the most potent being (R)‐PFI‐2. Herein we report structure–activity relationship studies on (R)‐PFI‐2 and its analogues. A library of 29 structural analogues of (R)‐PFI‐2 was synthesized and evaluated for inhibition of recombinantly expressed human SETD7. The key interactions were found to be a salt bridge and a hydrogen bond formed between (R)‐PFI‐2′s NH2+ group and SETD7′s Asp256 and His252 residue, respectively.