bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase‐20 in human cancers
Authors: Aseervatham Jaya , Geetu Saxena , Anunobi Charles C. , Koli Komal , Ogbureke Kalu U. E. 
Published: April 2019

AbstractBackgroundMatrix metalloproteinases‐20 (MMP20) expression is widely regarded as tooth specific, with expression limited to dental hard tissues. Recently, we reported MMP20 expression and interaction with dentin sialophosphoprotein (DSPP), a member of the Small Integrin Binding Ligand N‐linked Glycoproteins (SIBLINGs), in human oral squamous cell carcinoma (OSCC) and dysplastic oral premalignant lesions (OPLs), suggesting a role for MMP20‐DSPP interaction in oral carcinogenesis.MethodsThis study aimed to survey the expression of MMP20 and its cognate DSPP partner in the breast, colon, prostate, thyroid, and cervical neoplasms. Using commercially available tissue microarrays (TMAs) and cell lines, we performed immunohistochemistry, immunofluorescence, proximity ligation assay, and western blot experiments to determine the expressions of MMP20 and DSPP in the breast, colon, prostate, thyroid, cervical neoplasms, and their normal counterparts.ResultsSignificantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with advanced stages of colon and thyroid cancers. DSPP expression increased significantly with tumor stage in all cancers examined.ConclusionsThe co‐localization and potential MMP20‐DSPP interaction previously reported in oral cancers are present in other cancers. These results suggest MMP20‐DSPP pairing as a potential marker of disease activity in some epithelial cancers with diagnostic and prognostic implications.
Partly Deepithelialized Free Gingival Graft for Treatment of Lingual Recession
Authors: Kinaia Bassam M. , Kazerani Shahrdad , Hsu Yung‐Ting , Neely Anthony L. 
Published: April 2019

IntroductionGingival recession (GR) is an unhealthy root exposure that could result in sensitivity, abrasion, root caries and higher chance of plaque collection. The prevalence of GR is higher on the facial surfaces but could also affect the lingual tooth surfaces. Despite the etiology and location of GR, treatment is warranted to improve the long‐term periodontal stability around the affected teeth. This case report describes the use of partly deepithelialized free gingival graft (PE‐FGG) to augment lingual GR post orthodontic treatment.Case PresentationThe current report evaluates the results of PG‐FGG to correct lingual recession in a 21‐year‐old female. The patient presented with 5 mm lingual recession on a previously orthodontically rotated tooth (#21). The recession was treated using a PE‐FGG to increase keratinized gingiva (KG) and reduce root exposure. Follow‐up at 24 months showed adequate root coverage and KG.ConclusionThe use of PE‐FGG can be used to enhance KG for lingual recession with adequate root coverage.
Ectopic salivary gland fistula in the sternoclavicular joint region
Authors: Kato Agata , Tamada Ikkei , Aoki Marie , Kitabata Reina 
Published: April 2019

Key Clinical MessageAlthough rare, ectopic salivary gland fistula should be considered in the differential diagnosis when treating a fistulous lesion on the neck because its natural history and the level of difficulty of surgery are different from those of the branchial fistula.
Molecular Insights into the Ligand‐Reactant Interactions of Pt Nanoparticles Functionalized with α‐Amino Acids as Asymmetric Catalysts for β‐Keto Esters
Authors: Šulce Anda , Mitschke Nico , Azov Vladimir , Kunz Sebastian 
Published: April 2019

AbstractThe asymmetric hydrogenation of ß‐keto esters over α‐amino acid‐functionalized Pt nanoparticles was explored in order to expand our understanding of ligand‐reactant interactions underlying the chiral induction. A comprehensive investigation aimed at the quantification of the nonlinear effects demonstrated that for most of the ligands and reactants enantiodifferentiation is determined by 1 : 1 ligand‐reactant interaction. However, attachment of phenyl substituents to the ligands or reactants likely involves the formation of more intricate intermediate complexes. We have shown that the asymmetric bias is sensitive to even small changes in the geometry of the ligand. Additionally, we have found that alkali metal cations, which balance the negative charge of the ligand's carboxyl group and originate from the metal hydroxide used for ligand functionalization, play a key role in the process of chiral induction. As the nature of the cation can be varied by simply changing the metal hydroxide used during functionalization, this finding opens an additional possibility to control the stereoselectivity by tuning the ligand‐reactant interaction.
Facile Synthesis of Pt Icosahedral Nanocrystals with Controllable Sizes for the Evaluation of Size‐Dependent Activity toward Oxygen Reduction
Authors: Zhao Ming , Holder Joseph , Chen Zitao , Xie Minghao , Cao Zhenming , Chi Miaofang , Xia Younan 
Published: April 2019

AbstractPlatinum icosahedral nanocrystals are intriguing catalytic materials owing to the presence of a large number of twin boundaries and well‐defined {111} facets on the surface. However, there are only two protocols available for their synthesis and the protocols required either the involvement of a metal carbonyl as the reductant or a very long reaction time up to one week. Here we report a facile route to the quick synthesis of Pt icosahedral nanocrystals with tunable sizes. The synthesis only involved Pt(acac)2, tetraethylene glycol, poly(vinyl pyrrolidone), and as the metal precursor, solvent/reductant, and colloidal stabilizer, respectively. Noticeably, the synthesis could be completed within 20 min. By simply varying the amount of the precursor, we were able to tune the size of the Pt icosahedral nanocrystals in the range of 10–25 nm. Additionally, when ascorbic acid was introduced as a co‐reductant to facilitate the reduction of the precursor, the size of the Pt icosahedral nanocrystals could be further reduced down to 7–12 nm. When used as a catalyst towards the oxygen reduction reaction, the Pt icosahedral nanocrystals with different sizes all exhibited a specific activity more than 2.4 times greater than that of commercial Pt/C. Moreover, their specific activity increased with the particle size. After 5,000 cycles of the accelerated durability test, the specific activities of the Pt icosahedral nanocrystals with three different sizes were still more than 2 times as high as that of the commercial Pt/C catalyst.
BaB2O3F2: A Barium Fluorooxoborate with a Unique [B2O3F]− Layer and Short Cutoff Edge
Authors: Huang Chunmei , Zhang Fangfang , Li Hao , Yang Zhihua , Yu Haohai , Pan Shilie 
Published: April 2019

AbstractSubstitution of oxygen by fluorine in the borate group offers a materials platform from which intriguing structure and functionality may arise. Herein, we report a new fluorooxoborate, BaB2O3F2, synthesized by introducing the F atoms into the BaO–B2O3 system. BaB2O3F2 exhibits a unique oxyfluoride layer
[B2O3F]− and a deep‐ultraviolet cutoff edge below 180 nm. The effect of the introduction of F atoms on the structure and optical property of the borate group has been investigated; this should be useful to further expand borate chemistry and materials.
An Unprecedented Interpenetrating Structure Built from Two Differently Bonded Frameworks: Synthesis, Characteristics, and Efficient Removal of Anionic Dyes from Aqueous Solutions
Authors: Wang Chih‐Ling , Hsieh Jui , Lee Li‐Wei , Wu Jing‐Yun , Hsiao Pu‐Yen , Chu Jean‐Ho , Wang Chih‐Min 
Published: April 2019

AbstractThe first example of one single crystal (NTOU‐5) containing two different organic‐inorganic hybrid open‐framework structures was obtained using a hydro(solvo)thermal method and structurally characterized by single‐crystal X‐ray diffraction. Remarkably, under the same synthetic conditions, the zinc ions are respectively coordinated by oxalic acid (OX) and 1,2,4,5‐tetrakis(imidazol‐1‐ylmethyl)benzene (TIMB) linkers to form two significantly different frameworks: anionic [Zn2(OX)3]2− and cationic [Zn(TIMB)]2+ networks that interweave with each other to give an unprecedented interpenetrating structure with two differently‐bonded open‐frameworks. From the inorganic chemistry perspective, it is extremely difficult to control to which metal center the oxygen‐donor linkers or/and nitrogen‐donor ligands bind. A mixed Co/Zn analogue was also obtained by a similar method. The single‐crystal XRD and EDS analyses indicate that the octahedral Zn ions of the anionic framework are replaced by cobalt cations, whereas the Zn ions in the tetrahedral positions of the cationic networks remain intact. This leads to the formation of the interpenetrating analogue with a mixed metal composition. Furthermore, NTOU‐5 shows structural stability and efficiently removes organic dyes from aqueous solutions at concentrations of 10 ppm.
Application of a Technofunctional Caseinate Hydrolysate to Replace Surfactants in Ice Cream
Authors: Ewert Jacob , Schlierenkamp Felix , Fischer Lutz , Stressler Timo 
Published: April 2019

AbstractThere is a demand for a clean label of ice cream in the food industry. To meet this requirement, alternative surfactants and hydrocolloids without an additive number have to be found. Here, a caseinate hydrolysate with improved interfacial properties was investigated as such an additive. Replacing only the surfactant resulted in ice cream characteristics, comparable to using a commercial emulsifier (INS 472b). Thus, a clean labeling of the surfactant using this hydrolysate is possible. By contrast, replacing the hydrocolloid additionally led to an unfavorable ice cream texture and stability.
Tailored management of primary gastrointestinal stromal tumors
Authors: Etherington Mark S. , DeMatteo Ronald P. 
Published: April 2019

Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and can form along the entire gastrointestinal tract. Over the last 20 years, considerable advances have been made in our understanding of the biology of GISTs. The advent of tyrosine kinase inhibitors has provided effective medical therapy for the first time. In fact, given that GIST typically is driven by either a KIT or PDGFRA gene mutation, it has become a paradigm of targeted molecular therapy. In addition, diagnostic and surgical techniques have been refined. Here, the critical aspects of primary GISTs and how they are now managed with an integrated approach are summarized. Treatment plans are developed based on specific pathologic and molecular features of the tumor. The authors outline the general principles of therapy and highlight some of the nuances. Particular focus is given to diagnosis, surgical considerations, and the use of preoperative and postoperative tyrosine kinase inhibitors.
Comparison of cytocentrifugation supernatant fluid and formalin‐fixed paraffin‐embedded tissue for targeted next‐generation sequencing
Authors: Janaki Nafiseh , Harbhajanka Aparna , Michael Claire W. , Bomeisl Phillip , Wasman Jay , Atchley Maureen , Miskiewicz Kristina , Alouani David , Sadri Navid 
Published: April 2019

BackgroundThe emergence of less invasive procedures coupled with the growth of molecular testing have created a need for clinical laboratories to optimize workflows to enable tissue preservation and ancillary testing. In the preparation of formalin‐fixed paraffin‐embedded cell blocks (FFPE CBs), there is a cytocentrifugation step for cell pellet extraction that results in postcentrifugation supernatant fluid (SN). This SN, which in most routine workflows is discarded, has been suggested to contain adequate cellular material for molecular testing. In the current study, the authors describe the use of DNA and RNA extracted from SN for the detection of clinically relevant biomarkers by next‐generation sequencing (NGS).MethodsAfter cell pellet removal, cytocentrifugation SN from 30 endobronchial fine‐needle aspiration rinses that were positive for malignancy on FFPE CB were collected. DNA and RNA were extracted from the SN and tested using an in‐house NGS Solid Tumor Focus Assay. The NGS results were compared with findings from corresponding FFPE samples.ResultsTesting was successful in all 30 samples. There was 100% concordance between variants observed in the SN and corresponding FFPE specimens, which included 50 single‐nucleotide variants, 9 copy number amplifications, 3 structural variants, and 2 indels. Furthermore, there was excellent correlation (correlation coefficient, 0.93) between the variant allele frequency of mutations observed in SN compared with that noted in corresponding FFPE CBs.ConclusionsCytocentrifugation SN is a valuable source for NGS, is comparable to FFPE that preserves tissue for other ancillary testing, and can reduce the failure rate of testing that may result from insufficient material being available in the CB.
Reducing the impact of geometric errors in flow computations using velocity measurements
Authors: Nolte David , Bertoglio Cristóbal 
Published: April 2019

AbstractNumerical blood flow simulations are typically set up from anatomical medical images and calibrated using velocity measurements. However, the accuracy of the computational geometry itself is limited by the resolution of the anatomical image. We first show that applying standard no‐slip boundary conditions on inaccurately extracted boundaries can cause large errors in the results, in particular the pressure gradient. In this work, we therefore propose to augment the flow model calibration by slip/transpiration boundary conditions, whose parameters are then estimated using velocity measurements. Numerical experiments show that this methodology can considerably improve the accuracy of the estimated pressure gradients and 3D velocity fields when the vessel geometry is uncertain.
Metal‐Free Photocatalysts for C−H Bond Oxygenation Reactions with Oxygen as the Oxidant
Authors: Zhang Yu , Schilling Waldemar , Das Shoubhik 
Published: April 2019

AbstractDirect and selective oxygenation of C−H bonds to C−O bonds is regarded as an effective tool to generate high‐value products. However, these reactions are still subject to challenges such as harsh reaction conditions, use of expensive transition metal catalysts, and involvement of stoichiometric oxidants. To avoid these, molecular oxygen would be ideal as oxidant, as the byproduct is water or hydrogen peroxide. Additionally, achieving these reactions by using metal‐free catalysts would contribute to green and sustainable chemical synthesis. This Minireview summarizes recent reports on C−H oxygenation reactions with metal‐free catalysts and molecular oxygen under visible‐light conditions.
Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges
Authors: Sipponen Mika Henrikki , Lange Heiko , Crestini Claudia , Henn Alexander , Österberg Monika 
Published: April 2019

AbstractTo liberate society from its dependence on fossil‐based fuels and materials it is pivotal to explore components of renewable plant biomass in applications that benefit from their intrinsic biodegradability, safety, and sustainability. Lignin, a byproduct of the pulp and paper industry, is a plausible material for carrying various types of cargo in small‐ and large‐scale applications. Herein, possibilities and constraints regarding the physical–chemical properties of the lignin source as well as modifications and processing required to render lignins suitable for the loading and release of pesticides, pharmaceuticals, and biological macromolecules is reviewed. In addition, the technical challenges, regulatory and toxicological aspects, and future research needed to realize some of the promises that nano‐ and microscaled lignin materials hold for a sustainable future are critically discussed.
Tackling Capacity Fading in Vanadium Redox Flow Batteries with Amphoteric Polybenzimidazole/Nafion Bilayer Membranes
Authors: Oldenburg Fabio J. , Nilsson Elisabeth , Schmidt Thomas J. , Gubler Lorenz 
Published: April 2019

AbstractVanadium flow batteries are among the most promising technologies for stationary energy storage applications if their cost of storage can be further decreased. Capacity fading resulting from imbalanced vanadium crossover is a key operating cost component. Herein, a new approach is reported to avoid this cost by balancing electrolyte transport with amphoteric bilayer Nafion/meta‐polybenzimidazole membranes. Within this system, the anion‐ and cation‐exchange capacity can be tuned in a straightforward manner by changing the thickness of the respective polymer layer to balance electrolyte transport for a given current density. At high current densities, a net migrative flux of vanadium directed towards the positive side is observed owing to the higher average charge of vanadium ions present at the negative side. The coulombic repulsion between the vanadium ions and the positive charges in the membrane counteracts this migrative transport and can reverse the direction of the net vanadium flux. For a technically relevant current density of 120 mA cm−2, a PBI thickness of 3–4 μm is required to balance the vanadium crossover and to minimize capacity fading.
Across the Board: Michael North on Carbon Dioxide Biorefinery
Authors: North Michael 
Published: April 2019

AbstractIn this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. M. North, who introduces the concept of a carbon dioxide biorefinery as a way of making carbon dioxide utilisation both environmentally beneficial and financially attractive and discusses the state of the art for carbon dioxide utilisation for fuels and bulk chemicals.
Fluorination of MXene by Elemental F2 as Electrode Material for Lithium‐Ion Batteries
Authors: Thapaliya Bishnu P. , Jafta Charl J. , Lyu Hailong , Xia Jiexiang , Meyer Harry M. , Paranthaman M. Parans , Sun Xiao‐Guang , Bridges Craig A. , Dai Sheng 
Published: April 2019

AbstractInvited for this month′s cover is the group of Dr. Sheng Dai at the University of Tennessee, Oak Ridge National Laboratory and Joint Institute for Advanced Materials. The image shows the transformation of 2D Mxene into novel 2D TiOF2 via low temperature direct fluorination. The Full Paper itself is available at 10.1002/cssc.201900003.
Modeling and simulation of temperature drift for ISFET‐based pH sensor and its compensation through machine learning techniques
Authors: Bhardwaj Rishabh , Sinha Soumendu , Sahu Nishad , Majumder Sagnik , Narang Pratik , Mukhiya Ravindra 
Published: April 2019

SummaryThe paper presents modeling and simulation of ion‐sensitive field‐effect transistor (ISFET)‐based pH sensor with temperature‐dependent behavioral macromodel and proposes to compensate the temperature drift in the sensor using intelligent machine learning (ML) models. The macromodel is built using SPICE by introducing electrochemical parameters in a metal‐oxide‐semiconductor field‐effect transistor (MOSFET) model to simulate ISFET characteristics. We account for the temperature dependence of electrochemical and semiconductor parameters in our macromodel to increase its robustness. The macromodel is then exported as a subcircuit element, which is used to design the readout interface circuit. A simple constant‐voltage, constant‐current (CVCC) topology is utilized to generate the data for temperature drift in ISFET pH sensor, which is used to train and test state‐of‐the‐art ML‐based regression models in order to compensate the drift behavior. The experimental results demonstrate that the random forest (RF) technique achieves the best performance with very high correlation and low error rate. Corresponding curves for output signal using the trained models show highly temperature‐independent characteristics when tested for pH 2, 4, 7, 10, and 12, and we obtained a root mean squared error (RMS) variation of ΔpH ≤ 0.024 over a temperature range of 15°C to 55°C in comparison with ΔpH ≤ 1.346 for uncompensated output signal. This work establishes the framework for integration of ML techniques for drift compensation of ISFET chemical sensor to improve its performance.
Evaluation of sulfate metabolites as markers of intramuscular testosterone administration in Caucasian and Asian populations
Authors: Esquivel Argitxu , Alechaga Élida , Monfort Nuria , Yang Sheng , Xing Yanyi , Moutian Wu , Ventura Rosa 
Published: April 2019

AbstractThe introduction of alternative markers to the steroid profile can be an effective approach to improving the screening capabilities for the detection of testosterone (T) misuse. In this work, endogenous steroid sulfates were evaluated as potential markers to detect intramuscular (IM) T administration. Fourteen sulfate metabolites were quantified using mixed‐mode solid‐phase extraction and analysis by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Urine samples after a single IM injection (100 mg) of T cypionate to six Caucasian and six Asian healthy male volunteers were analyzed. Principal component analysis (PCA) was used to characterize the sample cohort and to obtain the most useful markers for discrimination between pre‐ and post‐administration samples. For Caucasian volunteers, a separation between pre‐ and post‐administration samples was observed in PCA, whereas for Asian volunteers no separation was obtained. Seventeen ratios between sulfate metabolites were selected and further considered. Detection times (DTs) of each marker were evaluated using individual thresholds for each volunteer. The best results were obtained using ratios involving T and epitestosterone (E) sulfates in the denominator. The best marker was the ratio androsterone sulfate/testosterone sulfate (A‐S/T‐S) which prolonged the DT 1.2–2.1 times in respect to those obtained using T/E ratio in all Caucasian volunteers and 1.3–1.5 times in two Asian volunteers. Other ratios between A‐S or etiocholanolone sulfate and E‐S, and sulfates of etiocholanolone, dehydroandrosterone or epiandrosterone, and T‐S were also found adequate. These ratios improve the DT after IM T administration and their incorporation to complement the current steroid profile is recommended.