bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered TEG Parameters Identify Hypercoagulablilty and are of Diagnosis Value for Papillary Thyroid Carcinoma Patients
Authors: Lu Songsong , Kang Rui , Wang Yongchao , Zhu Mengjie , Zhao Lei , Xu Qinzhu , Song Ying , Liu Chen 
Published: September 2018

Abstract
Objective The goal of this study was to clarify the changes and clinical significance of thromboelastography (TEG) parameters in papillary thyroid carcinomas and nodular goiters.
Methods 62 nodular goiter (NG) patients and 53 papillary thyroid carcinoma (PTC) patients were included. Coagulation indicators, together with a series of TEG parameters were collected and analyzed, compared with results of 61 healthy controls (HC). Correlation analysis was conducted between routine coagulation indicators and TEG parameters. ROC curves were used to evaluate the potential diagnosis value of the TEG parameters that were altered in papillary thyroid carcinoma patients.
Results APTT and PT in papillary thyroid carcinoma group were statistically significant higher than that in control group (p<0.05). MPV was found to be higher in PTC than NG and healthy controls.R, K and SP levels were significantly lower in PTC group than that in HC group; Angle, CI and TPI levels were significantly higher in PTC group than that in HC group. Areas under the ROC curve of CI, TPI, and angle were 0.725, 0.714, and 0.687 for distinguishing PTC from HC, 0.662, 0.668 and 0.591 for distinguishing PTC from NG.
Conclusion TEG parameters are altered and indicate hypercoagulablilty status of papillary thyroid carcinoma patients; CI, TPI, and angle could be potential diagnosis indicators for detecting papillary thyroid carcinoma.
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura
Authors: Roose Elien , Vidarsson Gestur , Kangro Kadri , Verhagen Onno , Mancini Ilaria , Desender Linda , Pareyn Inge , Vandeputte Nele , Vandenbulcke Aline , Vendramin Chiara , Schelpe An-Sofie , Voorberg Jan , Azerad Marie-Agnès , Gilardin Laurent , Scully Marie , Dierickx Daan , Deckmyn Hans , De Meyer Simon , Peyvandi Flora , Vanhoorelbeke Karen 
Published: September 2018

AbstractImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by severe ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency, the presence of anti-ADAMTS13 autoantibodies and an open ADAMTS13 conformation with a cryptic epitope in the spacer domain exposed. A detailed knowledge of anti-ADAMTS13 autoantibodies will help identifying pathogenic antibodies and elucidating the cause of ADAMTS13 deficiency. We aimed at cloning anti-ADAMTS13 autoantibodies from iTTP patients to study their epitopes and inhibitory characteristics. We sorted anti-ADAMTS13 autoantibody expressing B cells from peripheral blood mononuclear cells of 13 iTTP patients to isolate anti-ADAMTS13 autoantibody sequences. Ninety-six B cell clones producing anti-ADAMTS13 autoantibodies were identified from which 30 immunoglobulin M (IgM) and 5 IgG sequences were obtained. For this study, we only cloned, expressed and purified the five IgG antibodies. In vitro characterization revealed that three of the five cloned IgG antibodies, TTP73–1, ELH2–1 and TR8C11, indeed recognize ADAMTS13. Epitope mapping showed that antibodies TTP73–1 and TR8C11 bind to the cysteine–spacer domains, while the antibody ELH2–1 recognizes the T2–T3 domains in ADAMTS13. None of the antibodies inhibited ADAMTS13 activity. Given the recent findings regarding the open ADAMTS13 conformation during acute iTTP, we studied if the cloned antibodies could recognize cryptic epitopes in ADAMTS13. Interestingly, all three antibodies recognize cryptic epitopes. In conclusion, we cloned three anti-ADAMTS13 autoantibodies from iTTP patients that recognize cryptic epitopes. Hence, these data nicely fit our recent finding that the conformation of ADAMTS13 is open during acute iTTP.
Why we need new architectural and design paradigms to meet the needs of vulnerable people
Authors: Chrysikou Evangelia 
Published: September 2018

AbstractResearch on the silver economy shows that products and services, which enhance personal autonomy and social cohesion, are common to successful enterprises that serve the needs of both older adults and their carers. Policymaking focuses on such interventions, mainly from medical-pharmacological and hi-tech perspectives, such as advancements in pharmaceuticals, wearable technologies and e-health applications or robotics. Aspects of the built environment—that is, human-made surroundings—are rarely considered worth exploring. Yet, the fact that we have created buildings, as opposed to many advanced technologies that we are yet to invent, does not necessarily make them fit for purpose for the needs of an ageing population. This is the case in all forms and scales of the built environment, from houses to transportation networks. This article argues that policies and interventions for active and healthy ageing could benefit from a broader integration framework that would allow our built surroundings, of all scales and complexities, to become part of the solution. This could be achieved through new architectural and design paradigms that, contrary to prevailing architectural education and practice, operate in harmony with human perceptions and physiology, especially for vulnerable and older adults. By better understanding the consequences of the built environment on the well-being of the older population and acting on this we could, first, prevent the environment being disabling for vulnerable people and, second, hopefully enable increased autonomy through interventions.
Revised M06 density functional for main-group and transition-metal chemistry
Authors: Wang Ying , Verma Pragya , Jin Xinsheng , Truhlar Donald G. , He Xiao 
Published: September 2018

Significance
Kohn–Sham density functional theory (KS-DFT) has been widely utilized for applications in chemistry, condensed-matter physics, and materials science, but the accuracy of KS-DFT depends on the approximations to the exchange–correlation functional, and thus functional development is very important. The M06 and M06-2X functionals, which are hybrid metafunctionals, have been widely used due to their broad applicability. In this study, we present a hybrid metafunctional called revM06 that has broader accuracy than either M06 or M06-2X. As a result, the revM06 functional is well suited for a broad range of applications on main-group chemistry, transition-metal chemistry, and molecular structure prediction. The reoptimization takes advantage of the better databases and of our recently developed strategy for obtaining smoother functionals.
The use of -ing and -ndo forms in sales contracts
Authors: López Arroyo Belén , Roberts Roda P. , Moreno Pérez Leticia 
Published: September 2018

Abstract
This paper analyzes the use of the -ing and -ndo forms in English and Spanish in sales contracts.
More specifically, it aims to answer three questions: 1. Do the -ing and the -ndo forms occur
more frequently in sales contracts than in general language? 2. Do English sales contracts contain more -ing
forms used in more syntactic functions than the Spanish -ndo in Spanish sales contracts? 3. Are both the
-ing forms and the -ndo forms found in all or most parts of the sales contracts retained for
this study? Our study is based on two comparable corpora of English and Spanish: a legal corpus containing sales contracts, and a
general corpus. Our corpora provide the following answers to the questions posed: 1. Both the -ing and the
-ndo forms occur more frequently in sales contracts than in general language; 2. There are more
-ing forms in English sales contracts than there are -ndo forms in Spanish sales contracts,
but in both cases, they are used in a variety of syntactic functions; 3. Both the -ing forms and the
-ndo forms are found in most parts of the sales contracts used in this study.
Beliefs and preferences for food-safety policies: a discrete choice model under uncertainty
Authors: Cerroni Simone , Notaro Sandra , Raffaelli Roberta 
Published: September 2018

AbstractOutcomes of food policies are highly uncertain. Therefore, the public’s support for these policies depends on individuals’ beliefs and the provision of scientific information. Using data collected from a discrete choice experiment survey, we explore whether new information regarding a food-safety policy influences respondents’ support, while controlling for risk and time preferences. Additionally, we examine if support depends on whether information is perceived as either good or bad news. Results from the estimation of parametric error component logit models, based on expected utility theory and rank dependent utility theory, suggest that good and bad news affects preferences and welfare measures.
Costs and benefits of a school-based health intervention in Portugal
Authors: Vieira Margarida , Carvalho Graça S 
Published: September 2018

Abstract
School-based programmes for preventing childhood obesity have been shown to be effective in improving eating habits and nutritional status, but few intervention programmes with a controlled design have included an economic evaluation. In this study, we conducted a cost-consequence analysis to evaluate the costs and the health benefits of the ‘Planning Health in School’ programme (PHS-pro) implemented in the Northern region of Portugal to 449 children of 10–14 years old. Previous study has showed that after PHS-pro, several anthropometric measures significantly improved in the intervention group (height, waist circumference and waist-height ratio) compared with the control group, followed by significant improvements on soft drinks, fruit and vegetables daily consumptions. Costs were estimated according the two phases of the programme: designing and preparation of schools, and school setting implementation, and included all the direct costs on human and material resources. PHS-pro total costs were estimated as 7915.53€/year with an intervention cost of 36.14€/year/child attending the programme. This is much lower than the direct costs for treating an obese adult in Portugal, which was calculated as 3849.15€/year. A scale-up costing projection for implementing the PHS-pro to a larger young population was estimated to be even lower: 18.18€/year/child. This cost-consequence analysis provided evidence that the PHS-pro was economically feasible especially if compared with the medical costs for treating adult obesity. The PHS-pro can be a beneficial investment and may give a promising contribution to addressing overweight over childhood and adolescence, which are developmental stages that determine adulthood chronic diseases.
Simultaneous Edit and Imputation For Household Data with Structural Zeros
Authors: Akande Olanrewaju , Barrientos Andrés , Reiter Jerome P 
Published: September 2018

Abstract
Multivariate categorical data nested within households often include reported values that fail edit constraints—for example, a participating household reports a child’s age as older than his biological parent’s age—and have missing values. Generally, agencies prefer datasets to be free from erroneous or missing values before analyzing them or disseminating them to secondary data users. We present a model-based engine for editing and imputation of household data based on a Bayesian hierarchical model that includes (i) a nested data Dirichlet process mixture of products of multinomial distributions as the model for the true latent values of the data, truncated to allow only households that satisfy all edit constraints, (ii) a model for the location of errors, and (iii) a reporting model for the observed responses in error. The approach propagates uncertainty due to unknown locations of errors and missing values, generates plausible datasets that satisfy all edit constraints, and can preserve multivariate relationships within and across individuals in the same household. We illustrate the approach using data from the 2012 American Community Survey.
Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific
Authors: Koepfli Cristian , Waltmann Andreea , Ome-Kaius Maria , Robinson Leanne J , Mueller Ivo 
Published: September 2018

Abstract
Across 8101 individuals in 46 villages, the proportion of Plasmodium spp. multiple clone infections (0%–53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%–38.4%), except for P. vivax in Solomon Islands (P &lt; .001). Thus this parameter was not informative to identify transmission foci. In contrast, prevalence by microscopy and qPCR correlated well.
Clinical/Abnormal Perspectives
Authors: Mastroianni George R. 
Published: September 2018

Abstract
Chapter 4 focuses on the considerable psychological literature devoted to the question of the role played by psychopathology in the Nazi movement and the Holocaust. Both the Nazi leaders and the German population as a whole were thought by some to exhibit signs of psychopathology. The dominant paradigm in psychology before, during, and shortly after World War II was psychoanalytic, and Freudian analyses were common. The notion that psychopathology played a significant role in either Nazism or the Holocaust has largely been abandoned. The psychological consequences of the horrific experiences to which many Holocaust survivors were subjected led to the identification of a disorder called by some “concentration camp syndrome.” Our modern-day understanding of posttraumatic stress disorder (PTSD) owes a considerable debt to the legacy of Holocaust survivors.
The Psychology of Surveillance and Sousveillance Video Evidence
Authors: Feigenson Neal R. , Spiesel Christina O. 
Published: September 2018

Abstract
This chapter reviews the psychological research that indicates why jurors are likely to find video evidence in general to be reliable, probative, and persuasive but also why their perceptions and interpretations of this evidence are prone to being biased by many factors of which they tend to remain largely unaware. These include jurors’ prior attitudes and beliefs, their current motivations, the visual and verbal contextualizations of the video at trial, and their emotional responses to the video. The chapter then examines surveillance and sousveillance video technology and discusses jurors’ potential responses to videos of high-profile police shootings. It concludes by arguing that jurors’ responses to video evidence may change over the course of the trial as that evidence is presented repeatedly and under different conditions, recommending potential trial reforms to assist jurors as they evaluate video evidence, and suggesting further research to explore this issue.
The Public Health System
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
This chapter explores the public health system as a whole, including the organizations, activities, and people who promote public health in the United States. It describes the agencies at the federal, state, tribal, local, and territorial levels that have been granted legal authority to act on behalf of public health, including the functions of each agency in promoting public health. The chapter examines the role of the healthcare system within public health and concludes with a short discussion of the evolving effort to improve the public health system through accreditation, governance, and evaluation.
A Transdisciplinary Approach to Public Health Law
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
This chapter introduces the transdisciplinary model of public health law, which rests on the recognition that public health law is not just the work of lawyers. The chapter explains key terms in the model, including public health law practice, legal epidemiology, and policy surveillance. It also discussed the concept of “mechanisms of legal effect,” which is central to conceptualizing and evaluating the impact of law on health.
Choosing a Legal Approach
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
This chapter reviews legal approaches that can be used to promote public health and address specific health problems. Legal approaches include prohibiting or mandating conduct and creating and enforcing licensing and permitting schemes. The chapter also discusses increasing the costs of unhealthy conduct through taxes or litigation and incentivizing healthy conduct through loans, grants, and tax credits. Legal approaches to public health challenges can also be addressed by changing the informational environment with labeling requirements or reporting mandates or modifying the built environment through zoning or Complete Streets policies. The chapter also identifies potential constitutional and practical limitations to each approach.
The Constitution, Federalism, and Federal Preemption
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
This chapter examines the role of the Constitution in federal government, defines federalism, and explains the types of federal preemption at play in public health policy. The chapter begins with an exploration of the US Constitution; it explains the Constitution’s history and the role that the Constitution plays in public health policy formation. The chapter next defines the concept of federalism and details the Supremacy Clause and the 10th Amendment. It briefly discusses the division of labor and authority between state/local governments and the federal government regarding public health laws. Lastly, the chapter delves into the concept of federal preemption. It applies the concepts of preemption to an in-depth example involving tobacco regulation; this example explores both express and implied preemption.
Federal Public Health Authority
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
This chapter explores the powers of Congress to pass federal public health laws and to delegate authority to federal agencies. The chapter starts with an explanation of Congress’s limited, enumerated powers and how this limits Congress to certain arenas of authority. It next explores the evolution Congress’s use of the Commerce Clause to pass public health laws, before exploring Congress’s use of the Taxing and Spending Clause. The chapter provides examples of how Congress has used both the Commerce Clause and its taxing and spending power to effectuate public health policy. Next, the chapter explains the National Federation of Independent Businesses v. Sebelius case; it details challenges to the Affordable Care Act’s individual mandate and Medicaid and explains the implications of the Supreme Court’s holdings. Lastly, the chapter explains Congress’s authority to delegate authority to federal administrative agencies to issue and enforce public health regulations.
Enforcement
Authors: Burris Scott , Berman Micah L. , Penn, and Matthew , Holiday Tara Ramanathan 
Published: September 2018

Abstract
Chapter 19 explores the issue of enforcement and explains its importance to the success of public health laws. The chapter reviews the scope of activities that comprise a comprehensive enforcement system including the design and drafting of the law, appropriations and budgeting, community outreach and education, and licensing and compliance assistance. It also identifies the variety of enforcement approaches, including investigations and inspections and sanctions for violations, and provides examples of enforcement in action. It also discusses the applicability of the 4th Amendment to agency investigations and inspections and the use of injunctions to enforcement the requirements in public health laws.
Thinking in Action and Beyond
Authors: Nunes Terezinha 
Published: September 2018

Abstract
Before children learn to use language, they learn about the world in action and by imitation. This learning provides the basis for language acquisition. Learning by imitation and thinking in action continue to be significant throughout life. Mathematical concepts are grounded in children’s schemas of action, which are action patterns that represent a logical organization that can be applied to different objects. This chapter describes some of the conditions that allow deaf or hard-of-hearing (DHH) children to learn by imitation and use schemas of action successfully to solve mathematical problems. Three examples of concepts that can be taught by observation and thinking in action are presented: the inverse relation between addition and subtraction, the concepts necessary for learning to write numbers, and multiplicative reasoning. There is sufficient knowledge for the use of teaching approaches that can prevent DHH children from falling behind before they start school.
The First Humans and the First Art
Authors: Hogh-Olesen Henrik 
Published: September 2018

Abstract
The chapter follows the aesthetic impulse back to human prehistory and looks at prehistoric art. In order to establish our aesthetic inclinations as a primary impulse—and not just as a surplus phenomenon appearing in high cultures in times of plenty, when people have no better things to do—it is important to track this impulse back to its first expression and to the material living conditions at the time. Regarding the origin of this primary impulse, it is interesting to consider who these people were in terms of psychology. Who were the creators of the prehistoric art, and what motivated this activity?
The Woman in Red and the Man with the Chrome-Plated Wheels
Authors: Hogh-Olesen Henrik 
Published: September 2018

Abstract
Chapter 4 looks at how key stimuli and brain programming affect our own species’ aesthetics and determine which shapes, colors, and landscapes humans are attracted to and consider beautiful. Like other animals, people are predisposed to respond to certain key stimuli, which have been associated with an expectation of functionality, fitness, and increased well-being. In other words, the perception of beauty represents a strong internal indicator, which it pays to be guided by in order to gain various benefits. In this investigation, the chapter enters the micro-processes of artistic creation. It looks at the aesthetic effects that make up an artwork and at the understanding of why something captivates and fascinates people. The right embellishment can transform a trivial everyday object into an overwhelming power object—a kind of fetish that means the world to us and costs a fortune. How does something like this happen?
Fiction and Narrative
Authors: Hogh-Olesen Henrik 
Published: September 2018

Abstract
Humans also create stories and dramatic settings that deal with the theme of what it means to be human. Humans live in narratives, and narratives are everywhere. This chapter looks at why humans spend that much time and resources on telling each other stories and dramatizing common human experiences. Which themes do these narratives revolve around? Are there universal themes? And what function do these symbolic universes have for our development and survival as individuals and as a species? Moreover, how and why do artistic expressions, themes, and forms change over time? The chapter lists existential, cognitive, and social functionalities .