bluuebunny/crossref_metadata_2025_split huggingface dataset:
Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma
Authors: Seo Ji‐Hye , Choi Hyun Woo , Oh Ha‐Na , Lee Mee‐Hyun , Kim Eunae , Yoon Goo , Cho Seung‐Sik , Park Seon‐Min , Cho Young Sik , Chae Jung‐Il , Shim Jung‐Hyun 
Published: August 2018

Licochalcone (LC) families have been reported to have a wide range of biological function such as antioxidant, antibacterial, antiviral, and anticancer effects. Although various beneficial effects of LCD were revealed, its anticancer effect in human oral squamous cancer has not been identified. To examine the signaling pathway of LCD’s anticancer effect, we determined whether LCD has physical interaction with Janus kinase (JAK2)/signal transducer and activator of transcription‐3 (STAT3) signaling, which is critical in promoting cancer cell survival and proliferation. Our results demonstrated that LCD inhibited the kinase activity of JAK2, soft agar colony formation, and the proliferation of HN22 and HSC4 cells. LCD also induced mitochondrial apoptotic events such as altered mitochondrial membrane potential and reactive oxygen species production. LCD increased the expression of apoptosis‐associated proteins in oral squamous cell carcinoma (OSCC) cells. Finally, the xenograft study showed that LCD significantly inhibited HN22 tumor growth. Immunohistochemical data supported that LCD suppressed p‐JAK2 and p‐STAT3 expression and induced cleaved‐caspase‐3 expression. These results indicate that the anticancer effect of LCD is due to the direct targeting of JAK2 kinase. Therefore, LCD can be used for therapeutic application against OSCC.
Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women
Authors: Yoo Jun‐Il , Kim Mi‐Ji , Na Jae‐Bum , Chun Yun‐Hong , Park Young‐Jin , Park Yongwhi , Hah Young‐Sool , Ha Yong‐Chan , Park Ki Soo 
Published: August 2018

AbstractBackgroundThe aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women.MethodsThis cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of people living in three rural communities. They were enrolled for studies on activity limitation due to age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. They were residents aged 40 years or older. They agreed to participate in this cohort from March 2016 to May 2017. Peripheral endothelial function was assessed by reactive hyperaemia‐peripheral arterial tonometry using EndoPAT2000 system. Hand grip strength was measured using a digital hand dynamometer.ResultsEndothelial function index assessed by EndoPAT was worse in the low grip strength group than that in the normal group of elderly women (1.54 ± 0.51 in the low grip strength group vs. 1.77 ± 0.67 in the normal group, P = 0.003). There was a positive correlation between hand grip strength and endothelial function (r = 0.176, P = 0.007). On stepwise multivariate analysis, endothelial dysfunction (reactive hyperaemia‐peripheral arterial tonometry index < 1.67) significantly increased the risk of low hand grip strength (odds ratio = 2.019; 95% confidence interval = 1.107–3.682; P = 0.022).ConclusionsEndothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia.
The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection
Authors: El Shahawy Mohamed S , Hemida Mahmoud H , El Metwaly Ibrahim , Shady Zakarya M 
Published: August 2018

Background/AimMany studies have investigated risk factors other than antibiotic resistance linked to Helicobacter pylori (H. pylori) eradication failure. The aim of this study was to study the effect of serum levels of 25‐hydroxy‐vitamin D (25[OH]D) on eradication rates of H. pylori infection.MethodsThis study included 150 patients diagnosed with H. pylori gastritis using magnifying narrow‐band imaging endoscopy supported by stool antigen test. Serum 25‐OH vitamin D levels were measured via the Enzyme‐Linked Immune Sorbent assay (ELISA) method before starting eradication therapy of H. pylori infection. All patients were treated with clarithromycin‐based triple therapy for 14 days. H. pylori eradication was determined via a stool antigen test performed 4 weeks after the end of therapy. According to the serum level of 25‐OH vitamin D levels, the patients were divided into two groups: group I (sufficient) had a vitamin D level of ≥20 ng/mL, while group II (deficient) had a vitamin D level of <20 ng/mL.ResultsOur results revealed that eradication was successful in 105 (70%) patients and failed in 45 (30%) patients. The mean 25[OH]D level was significantly lower in the eradication failure group compared to the successful treatment group (14.7 ± 4.5 vs 27.41 ± 7.1; P < 0.001). Furthermore, there were significantly more patients with deficient 25[OH]D levels in the failed treatment group, 30 (66.6%), compared to the successful group, 10 (9.5%) (P < 0.001).ConclusionsOur results demonstrated that 25‐OH vitamin D deficiency may be considered a risk factor related to eradication failure of H. pylori infection. In addition, a further randomized trial to evaluate the effect of vitamin D supplementation in H. pylori eradication is mandatory.
Enabling graduation for whom? Identifying and explaining heterogeneity in livelihood trajectories post‐cash transfer exposure
Authors: Sabates‐Wheeler Rachel , Sabates Ricardo , Devereux Stephen 
Published: August 2018

AbstractWe use a data set from a graduation programme in Rwanda to explore the heterogeneous livelihood pathways that programme participants follow during and after the programme period. We show that household characteristics, such as gender of household head and labour availability, will affect trajectories of change; yet, the impact of initial resources will depend on what outcomes are being measured and possible complementarities between them. This reinforces the importance of a multi‐sectoral strategy for supporting livelihoods. We conclude that certain types of households need longer on a programme, as well as additional support to local enabling factors to support graduation. Copyright © 2018 John Wiley & Sons, Ltd.
How Do High and Low Levels of Social Trust Affect the Long‐run Performance of Poor Economies?
Authors: Gundlach Erich , Svendsen Gert Tinggaard 
Published: August 2018

AbstractPoor countries with high levels of social trust are shown to experience a hump‐shaped pattern of long‐run growth. With social trust modelled as a human capital externality, a calibrated two‐sector model replicates the observed hump‐shaped growth path. The simulation results imply that a hypothetical poor economy with ahighlevel of social trust, when beginning at a relative income level of 16 per cent, may need about 160 years to reach 50 per cent of the income level of the leading countries. For a hypothetical poor country with alowlevel of social trust, the process of catching up may only begin after more than 150 years of relative stagnation. © 2018 John Wiley & Sons, Ltd.
Improved perfusion pattern score association with type 2 diabetes severity using machine learning pipeline: Pilot study
Authors: Chen Yuheng , Duan Wenna , Sehrawat Parshant , Chauhan Vaibhav , Alfaro Freddy J , Gavrieli Anna , Qiao Xingye , Novak Vera , Dai Weiying 
Published: August 2018

BackgroundType 2 diabetes mellitus (T2DM) is associated with alterations in the blood–brain barrier, neuronal damage, and arterial stiffness, thus affecting cerebral metabolism and perfusion. There is a need to implement machine‐learning methodologies to identify a T2DM‐related perfusion pattern and possible relationship between the pattern and cognitive performance/disease severity.PurposeTo develop a machine‐learning pipeline to investigate the method's discriminative value between T2DM patients and normal controls, the T2DM‐related network pattern, and association of the pattern with cognitive performance/disease severity.Study TypeA cross‐sectional study and prospective longitudinal study with a 2‐year time interval.PopulationSeventy‐three subjects (41 T2DM patients and 32 controls) aged 50–85 years old at baseline, and 42 subjects (19 T2DM and 23 controls) aged 53–88 years old at 2‐year follow‐up.Field Strength/Sequence3T pseudocontinuous arterial spin‐labeling MRI.AssessmentMachine‐learning‐based pipeline (principal component analysis, feature selection, and logistic regression classifier) to generate the T2DM‐related network pattern and the individual scores associated with the pattern.Statistical TestsLinear regression analysis with gray matter volume and education years as covariates.ResultsThe machine‐learning‐based method is superior to the widely used univariate group comparison method with increased test accuracy, test area under the curve, test positive predictive value, adjusted McFadden's R square of 4%, 12%, 7%, and 24%, respectively. The pattern‐related individual scores are associated with diabetes severity variables, mobility, and cognitive performance at baseline (P < 0.05, |r| > 0.3). More important, the longitudinal change of individual pattern scores is associated with the longitudinal change of HbA1c (P = 0.0053, r = 0.64), and baseline cholesterol (P = 0.037, r = 0.51).Data ConclusionThe individual perfusion diabetes pattern score is a highly promising perfusion imaging biomarker for tracing the disease progression of individual T2DM patients. Further validation is needed from a larger study.Level of Evidence: 1Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2019;49:834–844.
Biomechanics of the knee extensor mechanism and its relationship to patella tendinopathy: A review
Authors: Dan Michael , Parr William , Broe David , Cross Mervyn , Walsh William R. 
Published: August 2018

ABSTRACTThe term jumpers knee for patella tendinitis, as coined by Dr. Martin Blazina, is now commonly referred to as tendinopathy. He believed it was associated with patella alta. Since then multiple studies have failed to reliably show an association between patella tendinopathy and associated intrinsic risk factors. There is, unfortunately, a well‐established doctrine that the extensor mechanism is simply a pulley. The goal of the review is to examine the biomechanics of the extensor mechanism and apply this to studies investigating intrinsic risk factors for patella tendinopathy. A better understanding of the biomechanics of the extensor mechanism may stimulate the discovery of intrinsic risk factors for developing patella tendinopathy, and subsequent surgical options to address them. Clinical significance: The aim of this review is to direct future research into biomechanical risk factors for developing patella tendinopathy and subsequently, possible treatments. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3105–3112, 2018.
Investigation of carbon in the Allan Hills A77278 meteorite via 2D and 3D Raman microspectroscopy
Authors: Yesiltas Mehmet 
Published: August 2018

AbstractThis paper reports the first Raman spectral and imaging data on the ordinary chondrite Allan Hills A77278 (ALHA77278) in two and three dimensions. Mineralogy in the ALHA77278 meteorite appears to be mainly silicates (olivine and pyroxene) with some carbonaceous material in the matrix. Metal phases are also present in the studied sample. Two‐dimensional Raman spectral distribution maps show the locations of these chemical constituents. Several diamond grains are observed to be buried in olivine and extend down to a ~7‐μm depth in the sample, which might be contamination captured during the sample preparation. Raman spectral peak parameters for D and G carbon bands are presented and trends among these parameters are discussed. These spectral parameters, when compared with those of other meteorites reported in the literature, show similarity with unequilibrated ordinary chondrites and primitive carbonaceous chondrites. Estimated peak metamorphic temperature for the parent asteroid is calculated to be around ~260°C, which is comparable with lower metamorphic grade ordinary chondrites, indicating that the metamorphic grade of ALHA77278 might be less than 3.7, as it has been officially assigned. Three‐dimensional Raman tomographic measurements present visualizations of the identified chemical components in high resolution as well as the epoxy used during the preparation of the sample. Spatial distribution of epoxy is used to avoid these regions during the Raman spectral data extraction from the carbonaceous matter from a depth of the sample, which could otherwise complicate the datasets used to infer the thermal history of the ALHA77278 meteorite.
Reducing the cooking water‐to‐dried pasta ratio and environmental impact of pasta cooking
Authors: Cimini Alessio , Cibelli Matteo , Moresi Mauro 
Published: August 2018

AbstractBACKGROUNDDuring daily pasta cooking, the general consumer pays little attention to water and energy issues. The present study aimed to measure the cooking quality and environmental impact of a standard format of dry pasta by varying the water‐to‐dried pasta ratio (WPR) from 12 to 2 L kg−1.RESULTSIn the above WPR range, the cooked pasta water uptake (1.3 ± 0.1 g g−1), cooking loss (0.037 ± 0.009 g g−1) and degree of starch gelatinization (11.2 ± 0.8%) were approximately constant, whereas the main Texture Analysis parameters (eg, cooked pasta hardness at 30% and 90% deformation, and resilience) showed no statistically significant difference. As the WPR was reduced from 12 to 2 L kg−1, the specific electric energy consumption linearly decreased from 1.93 to 0.39 Wh g−1 and the carbon footprint and eutrophication potential of pasta cooking lessened by approximately 80% and 50%, respectively.CONCLUSIONCooking dry pasta in a large excess of water (ie, 10 L kg−1), as commonly suggested by the great majority of pasta manufacturers, might be pointless. Such a great mitigation with respect to the environmental impact of pasta cooking should be checked further for other commercial pasta formats and would highlight the need for novel and more suitable pasta cookers than those currently in use. © 2018 Society of Chemical Industry
Composition and physicochemical properties of dried berry pomace
Authors: Reißner Anne‐Marie , Al‐Hamimi Said , Quiles Amparo , Schmidt Carolin , Struck Susanne , Hernando Isabel , Turner Charlotta , Rohm Harald 
Published: August 2018

AbstractBACKGROUNDBerry pomace is a valuable but little used by‐product of juice manufacturing. When processed to a stable fruit powder, the composition differs from that of the whole fruit. To facilitate application in foods, a detailed knowledge of its composition and physicochemical properties is essential.RESULTSBlackcurrant, redcurrant, chokeberry, rowanberry and gooseberry were selected for analysis. All pomace powders had a high fibre content (> 550 g kg−1) and a fat content of up to 200 g kg−1. Despite identical milling conditions, the particle sizes of the pomace powders varied. This can be traced back to seed content and brittleness, which also becomes apparent with respect to surface characteristics. Blackcurrant pomace powder differed from other varieties in terms of its low water‐binding capacity (3.2 g g−1) and a moderate moisture uptake, whereas chokeberry pomace powder showed the highest polyphenol content and rowanberry pomace powder was rich in flavonols.CONCLUSIONThe results obtained in the present study provide a comprehensive overview of the properties of berry pomace powder and allow conclusions to be made regarding their applicability for use in complex food systems. © 2018 Society of Chemical Industry
Resection of abdominal inferior vena cava without graft interposition: Considerations in preserving renal function
Authors: Theodoraki Kassiani , Kostopanagiotou Konstantinos , Theodosopoulos Theodosios , Vassiliu Pantelis , Kizgala Polyxeni , Parasyris Stavros , Bouzalas Dionysios , Arkadopoulos Nikolaos , Smyrniotis Vassilios 
Published: August 2018

AbstractThe management of tumors involving or infiltrating the inferior vena cava (IVC) constitutes a great surgical challenge, since radical resection affords patients the only possibility for long‐term survival. These tumors can be resected without graft interposition, provided that there is adequate collateral circulation and that the renal function can be secured. Meanwhile, ligation of the left renal vein may be possible due to the existence of collateral circulation through the adrenal and gonadal veins. We briefly present our experience on renal outflow preservation through implantation of the right renal vein into the IVC stump or through diversion of the left renal vein into the inferior mesenteric vein.
Investigating value added from heritage assets: An analysis of landmark historical sites in Wales
Authors: Beynon Malcolm J. , Jones Calvin , Munday Max , Roche Neil 
Published: August 2018

AbstractWe reveal how tourist visitation to similar historical sites supports different levels of local gross value added (GVA). The paper shows how information on tourism activity at few historical sites can be used to analyse causal recipes defining whether sites support relatively high/low levels of GVA. Fuzzy‐set qualitative comparative analysis is employed to offer perspectives not possible with other analytical methods. The study reveals that for a set of similar heritage sites, that factors supporting local economic impacts are complex and with this having ramifications for management interventions around sites that seek to boost the economic impacts of visitation.
Genetic structure and recovery of white‐tailed deer in Missouri
Authors: Budd Kris , Berkman Leah K. , Anderson Michelle , Koppelman Jeff , Eggert Lori S. 
Published: August 2018

ABSTRACTThe white‐tailed deer (Odocoileus virginianus) of Missouri have undergone changes in the past 100 years. From a historical estimate of 700,000 individuals, deer were nearly extirpated from the state following overexploitation in the late 1800s. Despite this, deer have since undergone a rapid expansion to the current population of 1.4 million. Because of this complex recent history, we sought to understand the levels and distribution of genetic diversity in deer across Missouri. We genotyped 751 deer at 10 microsatellite loci and used genetic distance metrics and Bayesian clustering analyses to identify distinct genetic groups. We also sequenced the mitochondrial control region from a subset (n = 248) of deer to identify historical lineages. We found high levels of nuclear marker diversity (HE = 0.818) and low, but statistically significant, levels of differentiation among regions. The high level of mitochondrial diversity (48 haplotypes; haplotype diversity = 0.621–0.964) is reflected in a haplotype network that suggests the persistent signature of translocated lineages. Overall, the white‐tailed deer of Missouri now represent a highly diverse population with no indication that there are barriers to gene flow. This will be an important consideration for the management of disease resistance and spread throughout the state. © 2018 The Wildlife Society.
Refusal of Cancer‐Directed Surgery in Head and Neck Squamous Cell Carcinoma Patients
Authors: Crippen Meghan M. , Elias Marcus L. , Weisberger Joseph S. , Brady Jacob S. , Eloy Jean Anderson , Baredes Soly , Park Richard Chan Woo 
Published: August 2018

Objectives/HypothesisTo investigate the risk factors for refusal of recommended surgery in head and neck squamous cell carcinoma (HNSCC) treatmentStudy DesignRetrospective review of a national database.MethodsThe Surveillance, Epidemiology, and End Results database was queried for all cases of HNSCC from 1989 to 2014. Patients who underwent recommended surgery (N = 98,270) were identified and compared to patients who refused recommended surgery (N = 3,582). Groups were compared for patient demographics, socioeconomic variables, and tumor characteristics including stage, grade, and primary site. Binary logistic regression was performed to determine independent predictors of surgery refusal.ResultsOf the total population, 1.8% of patients refused cancer directed surgery. Following regression, the strongest predictors of surgery refusal were found to be age greater than 75years (odds ratio [OR]: 4.23 [95% confidence interval {CI}: 3.00‐5.96]), and stage III (OR: 4.19 [95% CI: 3.15‐5.57]) or stage IV at diagnosis (OR: 4.49 [95% CI: 3.46‐5.80]). Black race was significantly predictive (OR: 1.71 [95% CI: 1.37‐2.13]) as well as marital status other than married (OR: 1.76 [95% CI: 1.49‐2.07]) and Medicaid insurance status (OR:1.46 [95% CI: 1.20‐1.77]). Primary site of larynx (OR: 2.01 [95% CI: 1.71‐2.37]) or base of tongue (OR: 2.34 [95% CI: 1.87‐2.92]) additionally predicted surgery refusal.ConclusionsA number of demographic, socioeconomic, and tumor‐related variables are associated with refusal of cancer‐directed surgery in head and neck squamous cell carcinoma. Recognition of these factors may help identify situations where more active education and support are needed to help patients accept optimal care.Level of Evidence4Laryngoscope, 129:1368–1373, 2019
Reaction Specificity of Phospholipase D Prepared from Acinetobacter radioresistens a2 in Transphosphatidylation
Authors: Cao Kewei , Liu Yanjun , Tian Yingying , Zhang Qin , Cong Peixu , Li Hongyan , Xu Jie , Li Zhaojie , Wang Jingfeng , Mao Xiangzhao , Xue Changhu 
Published: August 2018

AbstractPhospholipase D (PLD) can react with phospholipids as substrates, generally phosphatidylcholine (PtdCho), and the PLD‐substrate intermediate can be cleaved by another alcohol, resulting in transphosphatidylation of the substrate, which can be used in the production of special lipids. In this study, the reaction conditions affecting the transphosphatidylation of PtdCho with serine were optimized and the reaction specificity of a novel PLD prepared from Acinetobacter radioresistens a2 was evaluated for transphosphatidylation with a variety of phospholipid substrates and head group donors. Based on the yield of phosphatidylserine, experimental kinetic data, maximum transphosphatidylation rate, and kinetic constant, the specificity of PLD in transphosphatidylation was found to be affected by unsaturated fatty‐acid phospholipid substrates. The catalytic efficiency of PLD prepared from A. radioresistens a2 on the synthesis of natural phospholipids is on the order of l‐serine > ethanolamine and glycerol ≫ inositol. Moreover, it was found that the transphosphatidylation of PtdCho with saccharides was related to the length of the carbon chain and the number of saccharide units.
On the canonical embedding of a JB*‐triple into its bidual
Authors: Isidro José M. 
Published: August 2018

AbstractWe prove that the canonical embedding of a JB*‐triple E into its bidual extends uniquely to a manifold embedding between the corresponding real Banach Lie groups of holomorphic automorphisms of their respective open unit balls and , the image being a closed (though not a direct) Lie subgroup of .
Synthesis of Polyfluoro Arylene‐Based Poly(arylenevinylene)s via Pd‐Catalyzed Dehydrogenative Direct Alkenylation
Authors: Saito Hitoshi , Kuwabara Junpei , Yasuda Takeshi , Kanbara Takaki 
Published: August 2018

AbstractIn this study, π‐conjugated poly(arylenevinylene)s are synthesized via the Pd‐catalyzed dehydrogenative direct alkenylation of polyfluoroarenes with diethenyl aromatic monomer. The introduction of a fluoro group promotes the cross‐coupling reaction, and the formation of the undesired homocoupling byproduct is minimized by optimizing the reaction conditions. The polycondensation reactions lead to the formation of poly(arylenevinylene)s with a well‐defined trans‐configuration. The obtained polymers are evaluated as emitting materials for organic light‐emitting diodes.