bluuebunny/crossref_metadata_2025_split huggingface dataset:
Louvor do Politeísmo
Authors: Otte Georg 
Published: March 2018

O texto foi publicado pela primeira em Philosophie und Mythos. Ein Kolloquium. (Berlim; Nova York: De Gruyter, 1979). Para esta tradução foi utilizada a coletânea de textos Odo Marquard, Abschied vom Prinzipiellen. (Stuttgart: Reclam, 1981). Essa coletânea também foi traduzida para o inglês sob o título Farewell to Matters of Principle: Philosophical Studies (Trad. M. Wallace et al. Nova York; Oxford: Oxford University Press, 1989).
A forma da letra para o estudo das letras
Authors: Camargo Iara Pierro de 
Published: March 2018

O livro impresso de literatura tem hoje, na maioria das vezes, um design simples e funcional, isto é, feito para a leitura. O design do livro pode, assim, passar despercebido pelos leitores e ser negligenciado pelos editores por sua suposta simplicidade: páginas compostas apenas com tipos. A tipografia, apesar de parecer pouco expressiva, por suas sutilezas de desenho e de sua composição, pode estabelecer relações com o texto literário e indicar o contexto histórico e cultural daquela publicação, como indicam pesquisadores da área da bibliografia e sociologia dos textos. A tipografia é portanto um poderoso paratexto da obra. Além de paratexto, seu uso pode influenciar na recepção e na experiência da leitura. Neste artigo, procuramos abordar as questões levantadas acima e evidenciar aspectos físicos do desenho das letras para incentivar que estudiosos da área da literatura se preocupem cada vez mais com esses elementos formais indispensáveis para a criação de um livro e a realização da escrita e da leitura.
Uma hipótese sobre a dimensão antropológica do livro em "el libro" de Jorge Luis Borges
Authors: Lee Henrique De Oliveira 
Published: March 2018

RESUMO: Jorge Luis Borges realizou em Belgrano uma palestra sobre um pequeno esboço de uma história do livro. Em sua palestra Borges isolou três conceitos ou paradigmas de livro, o livro dos antigos, o livro sagrado e o livro nação. A partir da fundamentação teórica da Antropologia Literária de Wolfgang Iser, formulamos uma hipótese sobre a dimensão antropológica do livro. Primeiramente, aproximamos a noção de livro em Borges com a noção de artefato da Antropologia, para então abordar os paradigmas de livro de Borges como uma descrição de certos conjuntos de relações recursivas entre o artefato livro e seus leitores. PALAVRAS-CHAVE: Livro; Jorge Luis Borges; Antropologia Literária
Clinical Approach to Asthma COPD Overlap Syndrome
Authors: Mutlu Dr. Pinar 
Published: March 2018

Asthma and chronic obstructive pulmonary disease (COPD) are major public health issues which are associated with high and already increasing prevalence and may cause morbidity, mortality, and socioeconomical costs (1-4). Although asthma and COPD are different entities, the differential diagnosis can be sometimes challenging and it can be impossible in some elderly patients (5). Furthermore, more than 40% of the patients with COPD have reported a history of asthma (6) and asthma is accepted as a risk factor for the development of COPD (7). It is well-known that, in patients with both COPD and asthma, the disease progresses more rapidly (8), the patients have a worse quality of life-related to the health status, and they have more frequent respiratory system exacerbations (9). In this patient population, there is an increased rate of comorbidities and frequent admissions to health centers, compared to the patients with asthma alone or COPD alone (10-11).
Changes in cerebral blood flow in rheumatology patients treated with rituximab
Authors: Utku Uygar , Çetin Gözde , Atilla Nurhan 
Published: March 2018

Objective: We
aimed to assess the effects of rituximab therapy on cerebral hemodynamics in rheumatic patients with transcranial
Doppler (TCD) ultrasonography. Methods: The study included seven patients aged 20-65 years
(2 patients with secondary interstitial lung involvement to rheumatoid
arthritis, 3 patients with systemic lupus erythematosus and lupus nephritis, 2
patients with scleroderma and secondary interstitial lung disease) who received
rituximab treatment due to rheumatic diseases. Healthy control group
(non-rheumatic group) consisted of seven age and sex-matched, randomly selected
persons did not have risk factors for atherosclerosis. Bilateral middle
cerebral artery peak-systolic, end-diastolic, and mean blood flow velocities,
Gosling’s pulsatility index values, and Pourcelot’s resistance index values
were recorded with TCD by a neurosonologist before rituximab
administration. Control TCD performed to the rheumatic group after six months
from the last rituximab dosage. Results: One patient was
male and six patients were female. Peak-systolic, end-diastolic and mean blood
flow velocities of rheumatic patients were significantly higher than healthy
group (p &lt; 0.001). Peak-systolic,
end-diastolic and mean blood flow velocities of rheumatic patients were
significantly decreased after rituximab therapy (p &lt; 0.001). Conclusions: This study
highlights that the increased cerebral blood flow is indirectly
associated with atherosclerosis regarding persistent inflammation in patients
with rheumatic diseases. It was thought that treatment with rituximab could
reverse this situation.
Êxtase e metrópole
Authors: Souza Pedro de 
Published: March 2018

São Paulo nasce sob a égide do movimento, da violência e da velocidade. Até atingir seu cúmulo, esse hoje gigante caleidoscópio que não cessa de girar, erguia-se já lá, como urbanicidade transformada...SEVCENKO, Nicolau. Orfeu extático na metropole: São Paulo, sociedade e cultura nos frementes anos 20. São Paulo, SP: Companhia das Letras, 1992. xxiii, 390p., [16]p. de estampas, il., 21 cm. Bibliografia: p. 353-376. ISBN 8571642621 (broch.).
Valores hematológicos de Bothrops atrox mantenidos en cautiverio en la ciudad de Lima
Authors: Trujillo Elizabeth , Elias Roberto , Silva Walter , Montes David 
Published: March 2018

La serpiente venenosa Bothrops atrox, comúnmente llamado Jergón de la Selva, es una especie nativa de la Amazonía Peruana y causa la mayor cantidad de accidentes ofídicos a nivel nacional, razón por la cual se mantiene en cautiverio en instituciones del Estado para la producción del suero antiofídico y para la investigación de su veneno. Entre los meses de noviembre y diciembre del 2008 se realizó el estudio hematológico de 24 especímenes de B. atrox aparentemente sanos, mantenidos en cautiverio en el Instituto Nacional de Salud (INS) y en el Serpentario Oswaldo Meneses (UNMSM), ambos en la ciudad de Lima. El objetivo principal fue determinar los parámetros hematológicos para esta especie en cautiverio. El hematocrito se determinó por el método del microhematocrito, el recuento de eritrocitos y leucocitos se realizó en una dilución de sangre 1:200 en solución isotónica de Natt y Herrick, con el uso de la cámara de Neubauer. Para el recuento diferencial leucocitario se realizaron frotices con tinción de Wright – Giemsa. Los valores promedio encontrados fueron: eritrocitos 555.42 x 103/ul; hemoglobina 7.48 g/dL; hematocrito 21%; volumen globular medio 383.02 fl; hemoglobina globular media 138.14 pg; concentración de hemoglobina globular media 35.91 %; leucocitos 4.45 x 103/ul; linfocitos 75.04%; monocitos 1.96 %; azurófilos 12.50 %; heterófilos 5.63 %; eosinófilos 2.96% y basófilos 1.63%. Se encontraron diferencias significativas en cuanto a la serie eritrocítica según el lugar de cautiverio. No se encontraron diferencias significativas en relación al sexo.
Development and evaluation of simulation based neurosurgery curriculum. Pilot study at the Poznan University of Medical Sciences.
Authors: Sokół Bartosz , Jankowski Roman , Więckowska Barbara , Gąsiorowski Łukasz , Czekajlo Michael 
Published: March 2018

Introduction. Neurosurgical emergencies are complex tasks. The current learning environment limits students’ ability to manage acute neurosurgical emergencies due to legal and safety concerns. Simulation provides an opportunity to participate in the care of neurosurgical emergencies and develop clinical decision making skills. Aim. We aim to determine whether neuroscience simulation curriculum improves student ability to: manage a critically ill patient, recognize neurosurgical emergencies, to assess how stress tolerance affects experience during simulations and effectiveness of students performance. The third objective is to develop a tool for student assessment.Material and Methods. The simulation was performed on SimMan 3G Human Patient Simulator (Laerdal Medical). Scenarios included common neurosurgical emergencies. Students were assessed before and after the course by completing a Likert type questionnaire. Response data was analysed using Cronbach’s reliability for Likert-type response data and Spearman's monotonic correlation. Results. 60 students of fifth and sixth year of medical studies attended the course. 39 students of them replied to the questionnaire. The simulated clinical experience was positive and it improved their knowledge about neurosurgical emergencies. There was an improvement in their confidence. Improvement in individual and team performance was also observed.Conclusions. Neurosurgical simulations improve students` ability to recognize neurosurgical emergencies. The level of stress related to simulation is important factor of the education process and should be reduced to improve students’ development. Our questionnaire is an effective tool for assessment of students experience during clinical simulations.
The pharmacodynamics of dexmedetomidine in elderly cardiac patients undergoing analgosedation in the ICU
Authors: Ber Justyna Alicja , Malec Mirosław , Bienert Agnieszka , Nowicka Małgorzata , Żurański Łukasz , Grześkowiak Edmund , Hartmann-Sobczyńska Roma , Sobczyński Paweł 
Published: March 2018

Aim. This study aimed to evaluate the pharmacodynamics of dexmedetomidine in elderly cardiac patients.Material and Methods. Twelve patients of 60 years or older and need for analgesia after surgery or as a result of critical health conditions were included into our study. Dexmedetomidine was administered intravenously as a continuous infusion without the initial dose. At the beginning the infusion was started at the rate of 0.7 µg/kg/h and then it was continued in the range of 0.17–1.39 µg/kg/h according to desired level of sedation. Information about heart rate, systolic, diastolic and mean arterial blood pressure, bispectral index and cardiac index were collected a few minutes before, during and in 12 hours after infusion of dexmedetomidine.Results. The hemodynamic data as well as BIS level were collected from 12 patients. The duration of dexmedetomidine infusion was less than 9 hours. For each patient the reduction in blood pressure and heart rate compared to the value before dexmedetomidine infusion was observed. We did not observe bradycardia in any patient. Appropriate sedation level was achieved using only dexmedetomidine and ranged from 60 to 80. In only 2 cases it was necessary to give a single dose of another sedative.Conclusions. To conclude, in the patients’ population involved in the study, which included older cardiac patients dexmedetomidne has been shown as a sedative agent which enabled to achieve desire level of sedation in the recommended ranges without episodes of bradycardia, however hypotension events were noted.
PERBAIKAN GENETIK ANGGREK ALAM Vanda spp MELALUI PERSILANGAN INTERSPESIFIK DALAM MENDUKUNG PERKEMBANGAN ANGGREK DI INDONESIA
Authors: Hartati Sri , Sumijati Sumijati , Pardono Pardono , Cahyono Ongko 
Published: March 2018

<p><em>Efforts to improve the genetic quality of orchids have constraints on seed propagation techniques crosses and from crosses. The study aims to: (1) obtain a cross technique that can produce seeds with high fertility rates, (2) to obtain a new hybrid character which has advantages in flower. The study was conducted at the Center for Plant Conservation Kebun Raya Bogor LIPI. Research was an interspecific crosses that </em><em>♀ Vanda celebica x </em><em>♂ Vanda tricolor, </em><em>♀ Vanda celebica x </em><em>♂ Vanda dearei, </em><em>♀ Vanda celebica x </em><em>♂ Vanda insignis. And crosses the reciprocal is </em><em>♀ Vanda tricolor x </em><em>♂ Vanda celebica, </em><em>♀ Vanda dearei x </em><em>♂Vanda celebica, </em><em>♀ Vanda insignis x </em><em>♂Vanda celebica. Crosses performed by crossing parent elected as male or female parent. Activities include characterization of elders, crosses, harvesting, seed dispersal, seed Deployment and transfer done aseptically in tissue culture laboratory. Observations included the </em><em>successful crossing, when formed fruit, ripe fruit, and formed protokorm. Of research produced 5 series hybrid to form protokorm is Vanda dearei x Vanda Celebica, Vanda celebica x Vanda dearei, Vanda insignis x Vanda celebica, Vanda celebica x Vanda insignis, Vanda celebica x Vanda tricolo. The success of crosses 33%- 100%, time required for seed maturation varies between 122-262 days, 16-23 days old </em><em>germinated.</em></p>
Motivasi Mahasiswa dalam Memanfaatkan Layanan Akhir Pekan Sebagai Inovasi Layanan di Perpustakaan IAIN Pekalongan
Authors: Junaeti Junaeti 
Published: March 2018

AbstractWeekend service is service on Saturdays and Sundays organized by IAIN Pekalongan Library. The results of research, note that there are two factors that motivates students utilizing the weekend services. These factors are. intrinsic factor caused by willpower oneself to improve achievement and quality yourself, adding insight and find serenity. And extrinsic factors are: first, the library which includes the hospitality of the officer, the officer's promptness in providing service, library collections, information retrieval, and the atmosphere of the library on the weekend service. Second, it is the duty of the courses from lectures, as the primary cause. students utilize the service on weekends. The third factor is the friends is often a visit to the library. The last factor is the parents.Students working on a final project or task specific courses given by lectures, it turns out that most do not have the ability regarding literacy information, so a form of innovation in library services development IAIN Pekalongan directed at matters relating to information literacy, information literacy skills such as training, guidance of literature searches, online research skills, and manage research references. AbstrakLayanan akhir pekan merupakan layanan pada hari Sabtu dan Minggu yang diselenggarakan oleh Perpustakaan IAIN Pekalongan. Dari hasil penelitian, diketahui bahwa ada dua faktor yang menjadi motivasi mahasiswa memanfaatkan jasa layanan akhir pekan tersebut. Faktor tersebut yaitu faktor intrinsik yang disebabkan oleh kemauan diri untuk meningkatkan prestasi dan kualitas diri, menambah wawasan dan mencari ketenangan. Dan faktor ekstrinsik yaitu: pertama, faktor perpustakaan yang meliputi keramahan petugas, kesigapan petugas dalam memberikan layanan, koleksi perpustakaan, penelusuran informasi, dan suasana perpustakaan pada layanan akhir pekan. Kedua, adalah tugas mata kuliah dari dosen, sebagai penyebab utama. mahasiswa memanfaatkan layanan pada akhir pekan. Ketiga adalah faktor terman yang sering berkunjung ke perpustakaan. Faktor terakhir adalah orang tua.Mahasiswa yang mengerjakan tugas akhir maupun yang mengerjakan tugas mata kuliah tertentu yang diberikan oleh dosen, ternyata sebagian besar belum mempunyai kemampuan mengenai literasi informasi, sehingga wujud inovasi pengembangan layanan di Perpustakaan IAIN Pekalongan diarahkan pada hal yang berkaitan dengan literasi informasi, seperti pelatihan literasi informasi skill, bimbingan penelusuran literatur, online research skill, dan mengelola referensi riset.
Perkembangan Penerbitan Jurnal Open Access Dalam Mendukung Komunikasi Ilmiah Dan Peranan Perpustakaan
Authors: Kiramang Khaeruddin 
Published: March 2018

Sekitar akhir abad ke-20, penerbitan jurnal sebagai salah satu bentuk komunikasi ilmiah (scholarly communication) mengalami masa krisis (serials crisis) yang ditandai dengan meroketnya biaya berlangganan jurnal (ACRL, 2003). Kuatnya kendali penerbitan ilmiah di tangan para konglomerat penerbitan komersial yang berakibat melemahnya kekuatan penerbit berbasis nir-laba dianggap sebagai penyebab utama dari krisis ini. Pesatnya komersialisasi penerbitan jurnal ilmiah serta naiknya biaya penerbitan pada saat itu membuat jurnal ilmiah semakin sulit diakses. Akhirnya, kemampuan perpustakaan untuk memenuhi kebutuhan pelanggannya menurun seiring dengan melemahnya kemampuan untuk melanggan jurnal (B.-C. Björk, 2017). Pada saat yang sama, perkembangan pesat teknologi informasi dan komunikasi (TIK) mulai menunjukkan dampak yang nyata terhadap perkembangan penerbitan ilmiah. Penyebaran dan penyimpanan dijital informasi ilmiah, termasuk, e-jurnal, membuka peluang penyediaan konten informasi dengan biaya murah dengan mengurangi biaya yang berkaitan dengan pencetakan dan distribusi hard copy. Perkembangan TIK juga membuka potensi untuk mengabaikan peran penerbit tradisional dengan menyajikan jurnal online langsung kepada pembaca. Akibatnya kemudian adalah berkembangnya konsep penerbitan Open Access (OA), sebuah strategi yang dikembangkan dan didukung oleh jaringan ilmuwan, penerbit, dan pustakawan sebagai solusi atas terjadinya krisis jurnal ilmiah. OA dianggap sebagai sebuah solusi yang strategis karena memungkinkan tersedianya “akses online terbuka” untuk karya ilmiah (Harnad, 2005; Suber, 2004). Berkaitan dengan hal di atas, tulisan ini akan memaparkan sekilas tentang perkembangan penerbitan jurnal OA dalam mendukung proses komunikasi ilmiah serta peran yang dapat dilakukan oleh perpustakaan dan pustakawan.
IAP Proteins Antagonist: An Introduction and Chemistry of Smac Mimetics under Clinical Development
Authors: Ali Rafat , Singh Shalini , Haq Wahajul 
Published: March 2018

Background:
Smac mimetics (also known as IAP antagonist) are a new class of
targeted drugs having a goal to suppress the IAPs, reestablishing the apoptotic pathways and
inducing cancer cell death. Therefore, development of Smac mimetics was considered an attractive
strategy for the development of new anticancer drugs. Lots of reviews have come in
yesteryears which mainly discussed the biology of IAPs and their role in cancer development.
None of these reviews focused on the chemical synthesis of Smac mimetics.

Methods:
Literature study was done by using standard bibliographic search engines like
scifinder, pubmed etc. The characteristic features of screened articles were described in the
review.

Results:
The review gives an introduction of IAP proteins and Smac mimetics. Readers will
gain an overview of the development of Smac mimetics with representative examples of both
monovalent and bivalent Smac mimetics as anticancer agents and an understanding of their
structure-activity relationships. Chemical synthesis of biologically important Smac mimetics
was discussed briefly in this review.

Conclusion:
Small molecules that mimic Smac are continuously progressing towards clinical
development. Smac mimetics are generally well tolerated and have demonstrated rapid suppression
of their target (the IAPs), activation of apoptosis and anti-tumor activity. Continuous
research has been done to generate even more insight into the function of IAP proteins to significantly
enhance the therapeutical potential of Smac mimetics.
Docking of Natural Products against Neurodegenerative Diseases: General Concepts
Authors: Ribeiro Frederico F. , Mendonca Junior Francisco J.B. , Ghasemi Jahan B. , Ishiki Hamilton M. , Scotti Marcus T. , Scotti Luciana 
Published: March 2018

Background:
Since antiquity, humanity has used medicinal plant preparations to cure its
ills, and, as research has progressed, new technologies have enabled more investigations on natural
compounds which originate from plants, fungi, and marine species. The health benefits that these
natural products provide have become a motive for treatment studies of various diseases.

Objective:
Among them, the neurodegenerative diseases like Alzheimer's and Parkinson's, a major
age-related neurodegenerative disorder. Studies with natural products for neurodegenerative diseases
(particularly through molecular docking) search for, and then focus on those ligands which offer
effective inhibition of the enzymes monoamine oxidase and acetylcholinesterase.

Method:
This review introduces the main concepts involved in docking studies with natural
products: and also in our group, which has conducted a docking study of natural products isolated
from Tetrapterys mucronata for inhibition of acetylcholinesterase.

Results:
We observed that compounds 4 and 5 formed more interactions than the theoretical ligand,
but that ligands with greater activity also interacted with residues HIS 381 and GLN 527.

Conclusion:
We have reported on our docking study performed with AChE and alkaloids isolated
from the plant Tetrapterys mucronata. Our docking results corroborate the experiments conducted,
and emphasize the positive contribution that these theoretical studies involving natural products
bring to the fight against neurodegenerative diseases.
Educação escolar em comunidades quilombolas do território de identidade do Velho Chico-BA
Authors: Macêdo Dinalva de Jesus Santana , Messeder Marcos Luciano Lopes , Queiroz Delcele Mascarenhas 
Published: March 2018

Este artigo visa apresentar algumas reflexões a partir de uma pesquisa de doutorado realizada em três escolas, situadas em comunidades quilombolas do município de Bom Jesus da Lapa-BA, no Território de Identidade do Velho Chico. Buscamos analisar de que modo a educação escolar dialoga com as especificidades étnicoculturais das comunidades quilombolas. Para a coleta de dados, utilizamos entrevistas semiestruturadas com professores, gestores, coordenadora pedagógica, pais e lideranças quilombolas, grupos focais com os alunos, análises dos projetos político-pedagógicos das escolas, observações de eventos, registros fotográficos e anotações em diário de campo. Os resultados demonstram que as escolas tratam as especificidades étnico-culturais das comunidades quilombolas de maneira pontual, descontextualizada e superficial, em datas comemorativas, no componente curricular de história, gincanas e outros eventos. Todavia, constatamos algumas experiências pedagógicas significativas que vêm transgredindo os currículos escolares para dialogarcom o universo sociocultural dos alunos
Motivações iniciais para elaboração de diretrizes da educação escolar quilombola na Bahia
Authors: Oliveira Suely Noronha de 
Published: March 2018

Para os quilombolas, a promulgação da Lei nº 10.639/2003, que torna obrigatório o ensino da história e da cultura afro-brasileira e africana nas instituições de ensino foi uma conquista, porém não o suficiente para atender demandas escolares e educativas deste grupo. Essa ausência motivou as organizações quilombolas a inserir a educação escolar quilombola como uma demanda no rol de debates sobre políticas públicas de diversidade em educação no Brasil. Este artigo apresenta uma pesquisa sobre o processo de construção de Diretrizes Curriculares para a Educação Escolar Quilombola no estado da Bahia e sua relação com a política nacional. Privilegia-se aqui uma análisedo processo local de construção da demanda no estado, focalizando as motivações iniciais e o contexto organizativo-político. A pesquisa utilizou a metodologia qualitativa, com observação participante, trabalho de campo de caráter etnográfico (Salvador-BA), análises de fontes escritas (documentos oficiais) e orais (conversações informais, participação em audiências públicas e entrevistas semiestruturadas com líderes quilombolas, gestores, consultores e investigadores). Como resultado foi produzida uma narrativa temporal analítica das motivações iniciais para a construção de Diretrizes Curriculares para a Educação Escolar Quilombola no estado da Bahia, identificando as continuidades e descontinuidades no seu desenvolvimento.