bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Mammographic Breast Density and Breast Cancer Biology Among Breast Cancer Women in Jordan
Authors: Al-Balas Hamzeh , AL-Balas Mahmoud , Herz Allah Shatha , Qudsi Azmi , Ramadan Moh'd Shafiq , Al Tawil Ghadeer , Baydoun Haneen 
Published: October 2024

Background: A breast mammogram is considered the gold standard modality for breast cancer screening. The sensitivity of breast mammograms is highly linked to mammographic breast density (MBD) which is strongly linked to women's age, ethnicity, and other factors. Higher breast density is considered one of the risk factors for breast cancer development and it can be associated with different pathological and biological features of breast cancer.
Methods: This is a retrospective review of 97 women with a diagnosis of breast cancer in a tertiary hospital in Jordan who were diagnosed in the period between 2018 and 2020. We compared patients with a positive status for estrogen (ER) or progesterone (PR) receptors (ER+/PR+) and others with negative receptors (ER-/PR-), in terms of their correlation with MBD.
Results: The analysis has included 97 patients. Of which, 87.6% had either a PR+ or an ER+, and 38.1% of patients were positive for HER2/neu protein. The sample mean age was 56.4 and most patients were obese (56.7%). MBD of our cohort was 30.9% (30/97) fatty, 29.9% (29/97) scattered, 23.7% (23/97) heterogeneously dense, and 15.5% (15/97) dense. The ER+/PR+ group was more associated with fatty (35.3% vs 0.0%) and scattered (31.8% vs 25.0%) MBD types than the ER-/PR- group, and less associated with the dense type (9.4% vs 58.3%), and the association was statistically significant (P < 0.001). However, no statistically significant correlation was found between MBD and the HER2/neu protein status.
Conclusion: According to our results, ER+/PR+ group patients tend to have fatty and scattered MBD types than the ER-/PR- patients. Larger randomized cohorts should investigate the association between breast cancer biological subtypes and MBD.
Evaluating Biomarker Dynamics in Breast Cancer Post-Neoadjuvant Chemotherapy: A Retrospective Cross-sectional Study
Authors: G Kiruthikasri , Khan Adil Aziz , Zaheer Samreen , Ahuja Sana , Zaheer Sufian 
Published: October 2024

Background: Neoadjuvant chemotherapy (NACT) is integral to breast cancer management, yet its influence on biomarkers, notably androgen receptor (AR), remains underexplored. This study examines post-NACT alterations in receptor status, including ER, PR AR, HER2 and Ki67 index in breast cancer patients.
Methods: A cross-sectional study, spanning three years at a tertiary care center, enrolled patients with invasive breast cancer undergoing mastectomy post-NACT. Pre- and post-NACT specimens underwent histological grading and immunohistochemistry for hormone status, HER2 status, and Ki67 index. Discordance between pre- and post-NACT receptor statuses and expression levels of biomarkers was assessed using McNemar’s and Wilcoxon signed rank tests respectively.
Results: Among 100 patients, 35 were assessed. Mean age was 43.83 years, with prevalent T1 tumors (34.3%) and N1 nodal involvement (37.1%). Post-NACT, 54.2% showed no histological grade change. Notable alterations included changes in ER (14.2%), PR (14.2%), and HER2 status (8.57%). AR expression showed a significant change following NACT (p=0.03), while ER expression exhibited a trend towards significance (p=0.06). Ki67 index decreased in only 5.7% of cases.
Conclusion: This study unveils intricate biomarker dynamics following NACT in breast cancer, with particular emphasis on AR, hitherto not evaluated. Larger investigations are imperative to elucidate clinical implications and tailor treatment strategies for breast cancer patients undergoing NACT.
Tuberculous Pleurisy in a Patient with a History of Breast Cancer: Diagnostic Challenges and Management Options
Authors: Imankulova Asel , Uulu Melis Sholpanbai , Mamytova Elmira , Monolov Nurbek , Tagaev Tugolbai 
Published: October 2024

Background: Tuberculosis (TB) and cancer are increasingly prevalent diseases that can be challenging to diagnose due to similarities in clinical and radiological findings. This case report describes a 46-year-old woman with a history of breast cancer who developed tuberculous pleurisy (TP).
Case presentation: A 46-year-old woman who underwent mastectomy and chemotherapy for BC in 2023 had hypertension, but no history of TB. The patient presented with dry cough, fever, and stomach discomfort, with an oxygen saturation level of 60%, but no respiratory distress before their appointment. Microscopy and culture tests were negative for Mycobacterium TB, A positive result was observed with an IFN-γ level of 0.35 IU/ml and 26% of the negative control after TB antigen stimulation. Histological analysis using hematoxylin and eosin staining showed Langhans giant cells, epithelioid cell granulomas, caseous necrosis, and necrotic foci. These findings indicate granulomatous inflammation with no signs of malignancy. Following the diagnosis, the patient received a daily dose of 300 mg isoniazid, 600 mg rifampin, 1500 mg pyrazinamide, and 10 mg pyridoxine for six months without any adverse effects.
Conclusion: Physicians must employ a combination of diagnostic techniques, including morphological and microbiological confirmation, to accurately diagnose pleural effusion in this patient population.
RISK BEHAVIOR, HEALTH PROMOTION, AND HYPERTENSION IN PRODUCTIVE COMMUNITIES IN THE UPTD TAPOS DEPOK AREA
Authors: Nina Nina , Rachma Pramudita Widya , Fathan Fadhillah , Hera Ramadhani Alicia , Aranda Rizky , Blandin Laleda Miranti , Gian Purnama Muhammad 
Published: October 2024

In 2021 at the Tapos Health Center, out of 9,352 hypertensive patients aged ≥ 15 years, only 1,547 people (16.5%) received standard services. This problem is a serious health challenge because hypertension contributes to the high mortality rate in the region. The purpose of this study is to identify the problem and its causes and provide alternatives to the existing problem. The research design used for this study is descriptive analytical. This research aims to identify problems and their causes and provide alternatives to existing problems. Data collection and observation were carried out offline and then the data was processed using the Matrix Criteria Method. The results obtained for the problem that is the top priority is the low public interest in health promotion. Therefore, alternative problem solving is needed that can increase public interest in participating in health promotion. As a solution, planning sustainable health programs related to hypertension is a top priority to increase public awareness and participation in hypertension prevention. The program includes periodic health checks, counseling, and joint sports activities. It is hoped that through this program, it can overcome the low public interest in health promotion and ultimately help reduce the risk of hypertension and improve overall public health.
More than a Case of Mistaken Identity: Adult Entertainment and the Making of Early Sexology
Authors: Bull Sarah 
Published: October 2024

<p>Sexology emerged as a discipline during a period of keen concern about the social effects of sexually explicit media. In this context, sex researchers and their allies took pains to establish the respectability of their work, a process that often involved positioning sexual science in opposition to erotic literature and images. This article argues that this presentation of sexual science obfuscated sex researchers’ complex relationship with erotic print culture, which during the late 19th and early 20th centuries provided sexual scientists with access to explicit material that served as evidence for theories about human sexuality, facilitated transnational exchanges of sexual-scientific thought by bringing sex research across borders, and introduced sex research to wider audiences. Erotic print culture can thus be seen as one of several fields that contributed to the interdisciplinary development of sexology and facilitated the diffusion of sexual-scientific theories. Sex researchers’ shifting, often ambivalent relationship with erotic print and its producers emphasizes that while the boundaries of sexology were extremely porous, they were also heavily policed: Working to establish a modern, respectable new branch of science, sexual scientists reframed the output of other fields of enquiry as products of their own, blotted their reliance on these sources from the historical record, and denigrated them in public writing. </p>
The impact of fintech on the efficiency of urban commercial banks in China-based on super slacks-based measures with undesirable output
Authors: Haoliang Wang , Yahya Mohamed Hisham Dato Haji , Rahim Norhuda Abdul 
Published: October 2024

This study endeavours to elucidate the influence of financial technology (fintech) on the operational efficiency of urban commercial banks in China. By scrutinizing the integration of Internet-based fintech solutions, it seeks to illuminate their potential for streamlining banking processes, elevating customer experiences and augmenting the precision of credit assessments and lending decisions through sophisticated data analytics and risk management tools. This research evaluates the efficiency of Chinese urban commercial banks employing the Super Slacks-Based Measure (Super-SBM) which incorporates undesirable output. Furthermore, it leverages the System Generalized Method of Moments (System GMM) to investigate fintech’s specific impact on urban commercial bank efficiency across various Chinese regions. The findings underscore fintech’s pivotal role in catalyzing digital transformation within banks, thereby bolstering operational efficiency and customer satisfaction. Moreover, this study highlights the critical importance of fintech in fortifying risk management capabilities within the banking sector. The insights gleaned from this research contribute to the banking industry’s sustainable growth and competitive resilience. Additionally, the findings furnish policymakers with empirical evidence to support the strategic integration of fintech and the optimization of banking service processes. Urban commercial banks can streamline operations, enhance customer experiences, refine credit assessments and ultimately attain higher efficiency and long-term sustainability levels in the rapidly evolving financial landscape by harnessing the transformative potential of fintech.
برنامج تدريبي لخفض السلوك العدواني لدى الأطفال ذوي اضطراب طيف التوحد
Authors: د. يحيى بن ضيف الله سعيد الشغيبي  
Published: October 2024

هدف البحث الحالي (برنامج تدريبي لخفض السلوك العدواني لدى الأطفال ذوي اضطراب طيف التوحد) إلى اختبار مدى فعالية البرنامج التدريبي القائم على العلاج بالفن لخفض السلوك العدواني لدى الأطفال من ذوي اضطراب طيف التوحد، ومعرفة مدى تأثير البرنامج التدريبي على المجموعة التجريبية بعد مرور فترة من تطبيق البرنامج، ولتحقيق هدفي البحث قام الباحث باستخدام المنهج التجريبي بتصميمه شبه التجريبي، وتكونت عينة البحث من (20) طفل من ذوي اضطراب طيف التوحد في مراكز التوحد بمدينة جدة بالمملكة العربية السعودية، وقد تكونت أدوات البحث من مقياس السلوك العدواني: إعداد (شنيب وشند، 2023)، والبرنامج التدريبي (إعداد الباحث)، وأشارت نتائج البحث إلى وجود فروق ذات دلالة إحصائية عند مستوى دلالة (α ≤ 0.05) في متوسط الرتب على السلوك العدواني بين أفراد المجموعة التجريبية والضابطة في القياس البعدي، ووجود فروق ذات دلالة إحصائية عند مستوى دلالة (α ≤ 0.05 ) في متوسط الرتب على السلوك العدواني بين أفراد المجموعة التجريبية في القياس القبلي والبعدي، وعدم وجود فروق ذات دلالة إحصائية عند مستوى دلالة (α ≤ 0.05 ) في متوسط الرتب على السلوك العدواني بين أفراد المجموعة التجريبية في القياس البعدي والتتبعي. وأوصت الدراسة بالتركيز على العلاج بالفن في خفض العديد من السلوكيات النمطية التكرارية والسلوكيات الحركية لدى الأطفال ذوي اضطراب طيف التوحد والقيام بالمزيد من الدراسات والأبحاث في هذا المجال والتي تستند للعديد من الاستراتيجيات لخفض السلوك العدواني لدى الأطفال من ذوي اضطراب طيف التوحد، بالإضافة إلى استخدام المداخل العلاجية التي تستند إلى العلاج التكاملي لخفض السلوك العدواني. كما أوصت هذه الدراسة بالقيام بالمزيد من البحوث والدرسات التي تفيد مجال الأطفال ذوي اضطراب طيف التوحد.
Effects of Intraoperative Lignocaine Infusion on Heamodynamics and Postoperative Analgesic Requirement after Day Case Laparoscopic Surgery
Authors: Shaheen Md Shafiul Alam , Sardar Kawsar , Khatun U H Shahera , Rahman Md Mushfiqur , Ahmed Raju , Abbasi Md Mahmud 
Published: October 2024

Background:Intravenous lignocaine is an amide local anaesthetic known for its analgesic, anti-hyperalgesic, anti-inflammatory and anti-arrhythmic properties. During perioperative period of laparoscopic surgeries haemodynamic alteration occurs due to laryngoscopy, intubation, and surgical excision, gas insufflation during pneumoperitoneum, inadequate analgesia and inadequate depth of anaesthesia. Intravenous lignocaine is often administered to suppress the haemodynamic response and as an analgesic agent. We aimed to evaluate the effect of intravenous infusion of lignocaine on haemodynamic response and post-operative analgesic requirement.
Objectives:The purpose of this study was to evaluate the effect of intravenous infusion of lignocaine on haemodynamic and postoperative analgesic requirements after laparoscopic day case surgeries.
Material and method:Four hundred Sixty (460) patients were selected who’s were going to be operated for laparoscopic surgeries (Laparoscopic Cholecystectomy, laparoscopic Hernioplasty, laparoscopic appendicectomy, Diagnostic laparoscopy due to infertility) were grouped into exposed (Group L) who were received lignocaine infusion @1mg/kg/hr and controlled (Group C) who were received placebo. Systematic random sampling was employed.
Results:Demographic characteristics were comparable between the groups p>0.05. In lignocaine group intraoperative mean systolic blood pressure, mean diastolic blood pressure, mean arterial blood pressure and mean heart rate were significantly lower than control group (p<0.05). Twenty four hour mean VAS score (0 – 10 cm) at immediate recovery, 1st, 2nd, 3rd, 6th, 12th and 24th hour were lower in lignocaine group (p<0.05). The mean time of first analgesic requirement were longer (120 minutes) in lignocaine group compared to 40 minutes in control group (p<0.001) and the mean total tramadol consumption is less in lignocaine group (p<0.001).
Conclusion:Intra operative lignocaine infusion causes more haemodynamic stability and decreases postoperative pain score, required longer time for first analgesic requirement and reduced total analgesic consumption in laparoscopic surgeries.
J Bangladesh Coll Phys Surg 2024; 42: 312-320
UPAYA GURU PENDIDIKAN AGAMA ISLAM DALAM MENINGKATKAN KARAKTER RELIGIUS SISWA DI SMPN 1 RANCABUNGUR
Authors: Umami Faizah 
Published: October 2024

The purpose of this study is to analyse the efforts of Islamic Religious Education teachers in improving the religious character of students at SMPN 1 Rancabungur, Bogor district. The research method used is a qualitative method. The technique of collecting data is through interviews, observation, and documentation. The data analysis technique is through the stages of data collection, data reduction, data presentation, verification and confirmation of conclusions. Checking and validating data using source triangulation. The results showed that (a) the efforts of PAI teachers at SMPN 1 Rancabungur, Bogor district in improving the religious character of students that making character development programs through PraKbm activities, providing examples to students, and implementing habituation activities. (b) Supporting factors for Islamic religious education teachers include policies and support from the headmaster as the leader, School facilities and infrastructure that can support character building activities, motivation and support from parents, cooperation of all parties in improving student religious character. (c) The inhibiting factors of Islamic religious education teachers in improving the religious character of students at SMPN 1 Rancabungur are students' backgrounds and lack of student awareness.
A cross-sectional study in adiponectin, glucose metabolism, and body composition in cystic fibrosis
Authors: Nielsen Bibi Uhre , Mikkelsen Christine Råberg , Oturai Peter Sandor , Krogh-Madsen Rikke , Katzenstein Terese Lea , Ritz Christian , Pressler Tacjana , Almdal Thomas Peter , Mathiesen Inger Hee Mabuza , Faurholt-Jepsen Daniel 
Published: October 2024

ObjectiveWe hypothesized that the insulin-sensitizing adipokine adiponectin (ADP) is upregulated in cystic fibrosis (CF) related diabetes (CFRD) and underweight adults with CF. We aimed to assess correlations between glucose metabolism, body composition and ADP in CF.MethodsWe performed a cross-sectional study among adults with CF at the Copenhagen CF Center. The study included a fasting level of ADP, an oral glucose tolerance test (OGTT), and a dual energy-x-ray absorptiometry scan.ResultsIn total, 115 patients were included of whom 104 had an OGTT performed. Glucose intolerance was not correlated with ADP in multivariable analysis, while increased hepatic insulin resistance (i.e., HOMA-IR) was correlated with reduced ADP levels. ADP declined by 4% (eβ 0.96, 95% CI: 0.94, 0.98), 5% (eβ 0.95, 95% CI: 0.93, 0.98), 9% (eβ 0.91, 95% CI: 0.87, 0.95), and 83% (eβ 0.17, 95% CI: 0.08, 0.37) for each one unit (kg/m2) increase in body mass index, fat mass index, muscle mass index, and bone mineral content index, respectively.ConclusionsIn CF, ADP was negatively correlated with hepatic insulin resistance as well as low fat, muscle, and bone mass, but not with glucose intolerance. This suggests that malnutrition leads to higher ADP levels in CF.
Histological ovarian features and hormonal determinations in assigned females at birth transgender individuals according to different testosterone preparations
Authors: Borrás Aina , Barral Yasmina , Fabregues Francesc , Casals Gemma , Mora Mireia , Orois Aida , Méndez Marta , Saco Adela , Goday Anna , Manau Dolors 
Published: October 2024

IntroductionDistinct androgen formulations have been used as gender-affirming hormone treatment, but little is known about the specific changes that may occur in the ovary depending on the testosterone preparation used. The study aims to evaluate the histological modifications of the ovarian tissue and the hormonal changes after gender-affirming surgery based on the testosterone preparation employed, such as testosterone cypionate or undecanoate.DesignUnicenter transversal cohort study.Materials and methodsSixty transmasculine persons before and after gender-affirming surgery. A histological examination of the ovaries was conducted, including the follicular population and the characterization of the ovarian stroma. Hormonal status (testosterone, estradiol, FSH, and LH) were also assessed before and after the procedure.ResultsThe median age of participants was similar between the two groups (27.9 vs. 26.7 years, p = 0.27). There were no differences in all hormonal determinations before gender-affirming surgery between the groups. After surgery, FSH levels increased significantly, especially in the testosterone undecanoate group compared to the cypionate group (72.3 vs. 38.3 U/L, p = 0.02), consistent with LH determinations (43.0 vs. 23.4 U/L, p = 0.02). However, no regimen modification was required for any individual. No statistical differences were observed in any parameter concerning the follicular population, nor were there any variances in the thickness of the tunica albuginea (p = 0.85) or the proportion of luteinized stromal cells. Nevertheless, there was a tendency toward increased luteinization in the testosterone cypionate group (88.2% vs. 76.9%, p &gt; 0.05).ConclusionsIn a cohort of transmasculine individuals using different androgen preparations, histological analysis of ovarian tissue revealed comparable findings. Both groups exhibited similar follicular populations and comparable modifications in stromal tissue. However, significant differences were observed in hormonal profiles, although no modification in testosterone dosage was needed.
Mizhuo Guanchangye enema delays the decline of renal function in rats with chronic kidney disease by intervening in the TLR4/MyD88/NF-κB pathway
Authors: Li Han , Xu Peng , Zhang Xiaomei , Ye Naijing , Xu Fang , Liang Bo 
Published: October 2024

BackgroundChronic kidney disease (CKD) is a prevalent chronic condition that poses a significant threat to human health. There is a close connection between the gut and kidneys, jointly influencing the onset and progression of CKD through the “gut-kidney axis.” Traditional Chinese medicine has shown potential in CKD treatment, but the specific mechanisms require further investigation.ObjectivesThis study aims to explore the protective effects of Mizhuo Enema (MZGCY) on kidney function in CKD rats by regulating the TLR4/MyD88/NF-κB signaling pathway.MethodsThe researcher employed a CKD rat model, which was divided into four groups: Control, Model, half-dose Mizhuo Guanchangye (1/2 MZGCY), and full-dose Mizhuo Guanchangye (MZGCY). Post enema administration, assessments were conducted on kidney function indicators, which included blood urea nitrogen (BUN), serum creatinine (SCR), and 24-h urinary protein. Additionally, measurements were taken for intestinal toxic substances such as indoxyl sulfate (IS) and lipopolysaccharide (LPS), as well as inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Examinations of pathological changes in both the intestines and kidneys were also performed. During this process, immunofluorescence was utilized to detect the expression levels of proteins toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and nuclear factor kappa B (NF-κB) in the intestinal tissues.ResultsIt was found that after enema treatment, the BUN, SCR, and 24-h urinary protein levels in the MZGCY and 1/2 MZGCY groups significantly decreased, indicating notable improvement in kidney function. Compared to the model group, the IS, LPS, IL-6, and TNF-α levels in the MZGCY and 1/2 MZGCY groups were significantly reduced. Immunofluorescence showed a marked decrease in the expression of TLR4, MyD88, and NF-κB proteins in the intestines of the MZGCY group.ConclusionMZGCY significantly reduces the levels of intestinal toxins and inflammatory factors in the serum of CKD rats by interfering with the TLR4/MyD88/NF-κB signaling pathway, thereby improving intestinal and renal pathological changes and delaying CKD progression. This study demonstrates that MZGCY has significant renal protective effects, providing a new potential approach for CKD treatment.