bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial invasive imaging follow‐up of the first clinical experience with the Magmaris magnesium bioresorbable scaffold
Authors: Tovar Forero Maria Natalia , van Zandvoort Laurens , Masdjedi Kaneshka , Diletti Roberto , Wilschut Jeroen , de Jaegere Peter P. , Zijlstra Felix , Van Mieghem Nicolas M. , Daemen Joost 
Published: April 2019

AbstractObjectivesTo assess the performance of the commercially available Magmaris sirolimus‐eluting bioresorbable scaffold (BRS) with invasive imaging at different time points.BackgroundCoronary BRS with a magnesium backbone have been recently studied as an alternative to polymeric scaffolds, providing enhanced vessel support and a faster resorption rate. We aimed to assess the performance of the commercially available Magmaris sirolimus‐eluting BRS at different time points.MethodsA prospective, single‐center, nonrandomized study was performed at the Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. Six patients with stable de novo coronary artery lesions underwent single‐vessel revascularization with the Magmaris sirolimus‐eluting BRS. Invasive follow‐up including intravascular imaging using optical coherence tomography (OCT) was performed at different time points.ResultsAt a median of 8 months (range 4–12 months) target lesion failure occurred in one patient. Angiography revealed a late lumen loss of 0.59 ± 0.39 mm, a percentage diameter stenosis of 39.65 ± 15.81%, and a binary restenosis rate of 33.3%. OCT showed a significant reduction in both minimal lumen area (MLA) and scaffold area at the site of the MLA by 43.44 ± 28.62 and 38.20 ± 25.74%, respectively. A fast and heterogeneous scaffold degradation process was found with a significant reduction of patent struts at 4–5 months.ConclusionsOur findings show that the latest iteration of magnesium BRS suffers from premature dismantling, resulting in a higher than expected decrease in MLA.
PAGCM: A scalable parallel spectral‐based atmospheric general circulation model
Authors: Ren Xiaoli , Zhao Juan , Li Xiaoyong , Ren Kaijun , Song Junqiang , Sun Difu 
Published: April 2019

SummaryThe Atmospheric General Circulation Model (AGCM) as one of the most important components of Climate System Model (CSM), has been proved to be an effective way for weather forecasting and climate prediction. Although lots of efforts have been conducted to improve the computing efficiency of AGCMs, such as exploit parallel algorithms, migrating codes, and even redesigning systems to adapt to the emerging computer architectures, it is not enough to match the real requirement, due to the limited scalability of the parallel algorithms themselves. Therefore, we design and implement a scalable parallel spectral‐based atmospheric circulation mode called PAGCM in this paper. Specifically, we first analyze the data dependencies of the dimensions in different spaces according to the calculation characteristics of spectral models, and based on which we propose a two‐dimensional decomposition algorithm in PAGCM to effectively increase the involving cores for the parallel computing, and thus reduce the overall computing time. Furthermore, to adapt to the novel data decomposition in each computing stage of dynamic framework, we propose three‐dimensional data transposition algorithms and data collection algorithms correspondingly, by considering of load balancing and communication optimization. Extensive experiments are conducted on Tianhe‐2 to validate the effectiveness and scalability of our proposals.
Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL/6 mouse model
Authors: Esmaeilzadeh Emran , Soleimani Maryam , Zare‐Abdollahi Davood , Jameie Behnamedin , Khorram Khorshid Hamid Reza 
Published: April 2019

AbstractMultiple sclerosis (MS) is a common inflammatory disease of the central nervous system. Although the exact etiology of the disease is largely unknown, it is identified that cytokines may play an important role in the pathogenesis of MS. In this study, the effects of curcumin has been investigated on the expression levels of selected cytokine coding genes as well as the extent of demyelination in the corpus callosum of C57BL/6 experimental autoimmune encephalomyelitis (EAE) model of MS. Gene expression analyses revealed that treatment with curcumin could lead to a significant reduction in the expression levels of pro‐inflammatory cytokine coding genes including IL‐6 (p = 0.001), IL‐17 (p = 0.001), tumor necrosis factor (TNF)‐α (p = 0.008), and interferon (IFN)‐γ (p = 0.033) as well as a significant increase in the expression level of transforming growth factor (TGF)‐β (p = 0.006) as an anti‐inflammatory cytokine. Moreover, the expression of glutathione peroxidase (GPX)‐1 gene and the activity of anti‐oxidant enzymes were significantly higher (p < 0.001) in curcumin‐treated mice. Luxol fast blue staining also confirmed a significant reduction in the extent of demyelination in the curcumin‐treated group (p < 0.001). Our results have confirmed that curcumin is an effective therapeutic agent that could ameliorate the severity of EAE.
Secretive eating and binge eating following bariatric surgery
Authors: Lydecker Janet A. , Ivezaj Valentina , Grilo Carlos M. 
Published: April 2019

AbstractObjectiveSome individuals eat furtively and conceal evidence of eating, and this seems to occur beyond binge‐eating episodes. This type of secretive eating is common among youth and emerging evidences suggests that it is a relevant marker of eating disorder psychopathology among adults with significant eating and weight concerns.MethodWe assessed secretive eating, loss‐of‐control (LOC) eating, and eating disorder psychopathology using investigator‐based interviews among treatment‐seeking adults experiencing LOC eating following bariatric surgery (N = 168). Participants also completed an established depression measure; height and weight were measured.ResultsOverall, 37% of patients reported secretive eating: 54% of patients who met criteria for binge‐eating disorder except for the size criterion (“bariatric BED”) and 25% of patients with subthreshold bariatric BED reported secretive eating. Many clinical variables were higher among patients with secretive eating compared to those without secretive eating; however, only eating disorder psychopathology severity and body dissatisfaction remained significantly higher among patients with secretive eating compared to those without when bariatric BED status was also included as a variable in the model.DiscussionFindings suggest that among post‐bariatric surgery patients with LOC eating, secretive eating signals more severe eating disorder psychopathology overall and specifically related to dissatisfaction with weight and shape. Bariatric BED status, however, has a stronger association than secretive eating with many clinical variables. Secretive eating should be assessed and considered when addressing weight and shape concerns among patients experiencing LOC eating after bariatric surgery.
Detecting disease‐defining gene fusions in unclassified round cell sarcomas using anchored multiplex PCR/targeted RNA next‐generation sequencing—Molecular and clinicopathological characterization of 16 cases
Authors: Mantilla Jose G. , Ricciotti Robert W. , Chen Eleanor , Hoch Benjamin L. , Liu Yajuan J. 
Published: April 2019

AbstractDetection of disease‐defining gene fusions in sarcoma has led to refining their classification, as well as to discover several new entities. The advent of anchored multiplex PCR/targeted RNA next‐generation sequencing (AMP/RNA‐seq) has allowed for the development of scalable platforms that can simultaneously examine multiple fusion transcripts without prior knowledge of specific fusion partners.In this study, we assess the utility of a FusionPlex sarcoma panel analysis by AMP/RNA‐seq to detect disease‐defining gene fusions in 16 cases of undifferentiated round cell sarcoma in which prior diagnostic work‐up could not establish a definitive diagnosis. The clinical and pathologic features of these cases were correlated with the molecular findings. Validation of the method using 41 cases with known diagnoses showed analytic sensitivity and specificity of 98% and 100%, respectively. Of the 16 cases of undifferentiated round cell sarcoma, gene fusions were found in 9 (56%). These included three cases with CIC‐DUX4 fusion, two cases with BCOR‐CCNB3, and four single cases with CIC‐NUTM2A, HEY1‐NCOA2, EWSR1‐NFATC2, and NUT‐MGA1 fusions. Overall, despite some degree of morphologic overlap, all fusion‐positive cases had distinct morphologic features, which can be helpful for their histologic classification. We also describe the first adult case of MGA‐NUTM1 fusion sarcoma, as well as cartilaginous differentiation in a BCOR‐CCNB3 fusion sarcoma, which has not been previously reported. Our study demonstrated that FusionPlex sarcoma panel analysis, in the appropriate morphologic context, is a sensitive and precise ancillary method for the detection of disease‐defining gene fusions in undifferentiated round cell sarcomas, aiding in their definitive classification.
Dynamic imaging and quantification of subcellular motion with eigen‐decomposition optical coherence tomography‐based variance analysis
Authors: Wei Wei , Tang Peijun , Xie Zhiying , Li Yuandong , Wang Ruikang K. 
Published: April 2019

AbstractThe dynamic properties of subcellular organism are important biomarkers of the health. Imaging subcellular level dynamics provides effective solutions for evaluating cell metabolism and testing the responses of cells to pathogens and drugs in pharmaceutical engineering. In this paper, we demonstrate an innovative approach to contrast the subcellular motion by using eigen decomposition (ED)‐based variance analysis of time‐dependent complex optical coherence tomography signals. This method reveals a superior advantage of contrast to noise ratio when compared with the approach that employs intensity decorrelation. Furthermore, the eigen values derived from ED processing are calculated and applied to assess the power ratios of complex signal invariance that decreases exponentially along time dimension. The validation experiments are performed on the patterned samples of yeast powder mixed with gelatin/TiO2 water solution. Additionally, the proposed method is used to image mouse cerebral cortex in normal and pathological conditions, suggesting the practicality of variance power mapping in analyzing cortical neural activities. The technique promises efficient measurement of subcellular motions with high sensitivity and high throughput for in vivo and in situ applications.
Embryonic stem cells differentiated into neuron‐like cells using SB431542 small molecule on nanofibrous PLA/CS/Wax scaffold
Authors: Hoveizi Elham , Ebrahimi‐Barough Somayeh 
Published: April 2019

AbstractElectrospun nanofibrous scaffolds show huge potential to improve the neurological outcome in central nervous system disorders. In this study, we cultured mouse embryonic stem cells (mESCs) on an electrospun nanofibrous polylactic acid/Chitosan/Wax (PLA/CS/Wax) scaffold and surveyed the attachment, behavior, and differentiation of mESCs into neural cells. Differentiation in neural‐like cells (NLCs) was investigated with a medium containing SB431542 as a small molecule and conjugated linolenic acid after 20 days. We used Immunocytochemistry and quantitative real‐time polymerase chain reaction (RT‐PCR) techniques to assess neural marker expression in differentiated cells. SEM imaging demonstrated that mESCs could strongly attach, stretch, and differentiate on PLA/CS/Wax scaffolds. MESCs that were cultured on PLA/CS/Wax scaffolds showed enhanced numbers of neural structures and neural markers including Nestin, NF‐H, Tuj‐1, and Map2 in neural induction medium compared to the control sample. These results revealed that electrospun PLA/CS/Wax scaffolds associated with the induction medium can assemble proper conditions for stem cell differentiation into NLCs. We hope that the development of new technologies in neural tissue engineering may pave a new avenue for neural tissue regeneration.
Effects of Preoperative Extracorporeal Shockwave Therapy on Scar Formation—A Pilot Study on 24 Subjects Undergoing Abdominoplasty Surgery
Authors: Russe Elisabeth , Wechselberger Gottfried , Schwaiger Karl , Heinrich Klemens , Hladik Michaela , Traintinger Heike 
Published: April 2019

ObjectivesExtracorporeal shockwave therapy (ESWT) has been demonstrated as a feasible noninvasive method to improve wound healing. This effect was demonstrated to result from increased perfusion and angiogenesis due to systemic growth factor expression. We, therefore, hypothesized that preoperative ESWT reduces scar formation after surgery.MethodsA prospective, controlled pilot study on 24 patients undergoing abdominoplasty was conducted and the efficacy of preoperative unfocused, low energy EWST was evaluated. The right and left half of the operative area were randomly allocated to ESWT or placebo treatment in intrapatient control design. At 6 and 12 weeks after surgery, scar formation was evaluated by 19 different scar parameters included in the patient, observer scar assessment, and the Vancouver scar scale.ResultsThe overall rating of the Vancouver and POSAS scale with Mann–Whitney (MW) analysis revealed a clear trend favoring ESWT. At week 6, 7 of 19 parameters clearly favored ESWT (MW > 0.53). At week 12, 8 of 19 parameters clearly favored ESWT. The largest differences were observed in thickness and overall impression (Vancouver scar scale).ConclusionsESWT presumably reduces scar formation and postoperative symptoms after abdominoplasty surgery. Further studies are required to confirm ESWT efficacy with statistical significance. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.
Dynamic water/fat separation and inhomogeneity mapping—joint estimation using undersampled triple‐echo multi‐spoke radial FLASH
Authors: Tan Zhengguo , Voit Dirk , Kollmeier Jost M. , Uecker Martin , Frahm Jens 
Published: April 2019

PurposeTo achieve dynamic water/fat separation and field inhomogeneity mapping via model‐based reconstructions of undersampled triple‐echo multi‐spoke radial FLASH acquisitions.MethodsThis work introduces an undersampled triple‐echo multi‐spoke radial FLASH sequence, which uses (i) complementary radial spokes per echo train for faster spatial encoding, (ii) asymmetric echoes for flexible and nonuniform echo spacing, and (iii) a golden angle increment across frames for optimal k‐space coverage. Joint estimation of water, fat, inhomogeneity, and coil sensitivity maps from undersampled triple‐echo data poses a nonlinear and non‐convex inverse problem which is solved by a model‐based reconstruction with suitable regularization. The developed methods are validated using phantom experiments with different degrees of undersampling. Real‐time MRI studies of the knee, liver, and heart are conducted without prospective gating or retrospective data sorting at temporal resolutions of 70, 158, and 40 ms, respectively.ResultsUp to 18‐fold undersampling is achieved in this work. Even in the presence of rapid physiological motion, large field inhomogeneities, and phase wrapping, the model‐based reconstruction yields reliably separated water/fat maps in conjunction with spatially smooth inhomogeneity maps.ConclusionsThe combination of a triple‐echo acquisition and joint reconstruction technique provides a practical solution to time‐resolved and motion robust water/fat separation at high spatial and temporal resolution.
Morphological, rheological, and mechanical properties of hybrid elastomeric foams based on natural rubber, nanoclay, and nanocarbon black
Authors: Vahidifar Ali , Esmizadeh Elnaz , Rostami Ehsan , Nouri Khorasani Saied , Rodrigue Denis 
Published: April 2019

AbstractIn this study, compression molding was used to produce elastomeric nanocomposite foams based on natural rubber (NR) with a hybrid reinforcing system containing organo‐modified nanoscale (NC) and nanocarbon black (NCB). The effect of NC content (0‐10 part per hundred rubber, phr) on the curing behavior, as well as the morphological and mechanical properties of elastomeric foams containing 10 phr of NCB was determined. Transmission electron microscopy and X‐ray diffraction results showed that NC exfoliation occurred at low NC concentration (less than 5 phr), while increasing NC content up to 5 phr led to aggregation. Rheological data revealed that increasing the NC content up to 10 phr gradually changed the curing parameters such as 50% shorter scorch and curing time, two times faster curing rate, as well as higher initial (35%) and final (35%) torque. Scanning electron microscopy analysis also showed that increasing NC content from 0 to 5 phr produced foams with more uniform small cells, while 7 phr of NC changed the foam structure into two areas composed of different cell sizes and different cell densities. Higher NC content (10 phr) led to broken cell walls. With nanoparticles, higher foam modulus (83%) and hardness (104%) were observed. Finally, NC addition was found to improve the NR's thermal and thermo‐oxidative resistance while the sound absorption coefficient was constant.
LncRNA‐ENST00000501520 promotes the proliferation of malignant‐transformed BEAS‐2B cells induced with coal tar pitch mediated by target genes
Authors: Li Zhongqiu , Zhang Yaping , Meng Liya , Yang Sa , Zhang Peng , Zhang Jiatong , Li Chunyang , Feng Feifei , Zhang Qiao 
Published: April 2019

AbstractAs a human carcinogen, coal tar pitch (CTP) can significantly increase the risk of lung cancer. However, the mechanism underlying CTP‐induced lung carcinogenesis has not been well understood. This study aims to explore the role of the LncRNA‐ENST00000501520 in the proliferation of malignant‐transformed human bronchial epithelial cells (BAES‐2B) induced by CTP extract for the first time. BEAS‐2B cells were stimulated with 2.4 μg/mL CTP extract, and then passaged for three times, which were named passage 1 and then passaged until passage 30 (named as CTP group). The ENST000001520 of cells in CTP group was interfered using siRNA. The results showed that ENST000001520 located in cell nucleus (>80%) had no or weak ability of protein encoding. After interference of ENST000001520, the migration and proliferation of cells in CTP group were inhibited, and the cell cycle was arrested in the G0/G1 phase; however, the apoptosis of cells in CTP group was promoted. The target genes (SKB1, CLTB, TAP2, PIPK2, and SOCS3) of ENST000001520 were screened out, and the mRNA and protein expression of SBK1 and SOCS3 was significantly decreased after ENST000001520 interference. SBK1 and SOCS3 may play a promoting role in occurrence and development of cancers. The study suggests that LncRNA‐ENST00000501520 could promote the proliferation in malignant‐transformed BEAS‐2B cells induced with CTP extract which may be mediated by target genes. This study may provide a new target for prevention and treatment of lung cancer.
Effectiveness of various wetland vegetation species on mitigating water pollution from highway runoff
Authors: Luo Yanzhang , Sun Shiqing , Zhang Hui 
Published: April 2019

AbstractThis study selected and tested five submerged aquatic vegetation‐based (SAV) wetlands to improve highway runoff treatment in best management practices. The removal efficiencies of suspended solid (SS), chemical oxygen demand (COD), total nitrogen (TN), ammonia nitrogen (), and total phosphorus (TP) in the five SAV wetlands were analyzed. Furthermore, the lead (Pb) and zinc (Zn) accumulation capabilities of five submerged macrophytes were determined. The obtained results show that Ceratophyllum demersum wetlands achieved the highest nutrient removal and had the heavy metal accumulation property. Vallisneria natans showed the highest bioaccumulation of Pb among all tested species. Ceratophyllum demersum wetlands showed the highest average removal efficiencies of SS (82.97%), COD (62.08%), TN (77.63%), (76.24%), TP (77.55%), Pb (96.24%), and Zn (91.23%). The tendencies of contaminant removal showed seasonal variation, and SAV wetlands performed better in summer than in spring and autumn. Consequently, SAV wetlands showed selectivity for contaminant removal.Practitioner points

Chemical oxygen demand (COD), total nitrogen (TN), and total phosphorus (TP) in highway runoff were removed by submerged aquatic vegetation (SAV).

Ceratophyllum demersum and Myriophyllum spicatum wetlands performed well on heavy metal removing.

Ceratophyllum demersum showed the highest removal efficiencies of TSS, COD, TN, , and TP.

The SAV wetlands performed better in summer than in other seasons.
Effective potential for revolving D-branes
Authors: Iso Satoshi , Ohta Hikaru , Suyama Takao 
Published: April 2019

AbstractWe quantize an open string stretched between D0-branes revolving around each other. The worldsheet theory is analyzed in a rotating coordinate system in which the worldsheet fields obey simple boundary conditions, but instead the worldsheet Lagrangian becomes nonlinear. We quantize the system perturbatively with respect to the velocity of the D-branes and determine the one-loop partition function of the open string, from which we extract the short-distance behavior of the effective potential for the revolving D0-branes. It is compared with the calculation of the partition function of open strings between D0-branes moving at a constant relative velocity.
Exercising abilities
Authors: Carter J. Adam 
Published: April 2019

AbstractAccording to one prominent view of exercising abilities (e.g., Millar in Acta Anal 24(4):223–236, 2009), a subject, S, counts as exercising an ability to $$ \phi $$
ϕ
if and only if S successfully $$ \phi $$
ϕ
s. Such an ‘exercise-success’ thesis looks initially very plausible for abilities, perhaps even obviously or analytically true. In this paper, however, I will be defending the position that one can in fact exercise an ability to do one thing by doing some entirely distinct thing, and in doing so I’ll highlight various reasons (epistemological, metaphysical and linguistic) that favor the alternative approach I develop over views that hold that the exercise of an ability is a success notion in the sense Millar maintains.
Analysis of spatiotemporal variations in the characteristics of soil microbial communities in Castanopsis fargesii forests
Authors: Qiao Hongyong , Luan Yaning , Wang Bing , Dai Wei , Zhao Mengsai 
Published: April 2019

AbstractCastanopsis fargesii is a good afforestation plants and various microorganisms play important roles in mediating the growth and ecological functions of this species. In this study, we evaluated changes in microbial communities in soil samples from C. fargesii forests. The phospholipid fatty acid (PLFA) biomarker method was used to obtain bacteria, fungi, actinomycetes, gram-positive bacteria (G+), gram-negative bacteria (G−), aerobic bacteria, and anaerobic bacteria to investigate spatiotemporal changes in microbial communities during the growing season. The results show that soil microorganisms were mainly concentrated in the upper 20-cm layer, demonstrating an obvious surface aggregation (P < 0.05). Large amounts of litter and heavy rainfall during the early growing season resulted in the highest PLFA contents for various microorganisms, whereas relatively low and stable levels were observed during other times. The dominant species during each period were bacteria. G+ or aerobic bacteria were the main bacterial populations, providing insights into the overall trends of soil bacterial PLFA contents. Due to the relative accumulation of refractory substances during the later stages of litter decomposition, the effects of fungi increased significantly. Overall, our findings demonstrate that the main factors influencing microbial communities were litter, rainfall, and soil field capacity.