bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of IC components on innovation performance in Serbian companies
Authors: Cabrilo Sladjana , Kianto Aino , Milic Bojana 
Published: July 2018

PurposeIn investigating the linkage between intellectual capital (IC) and innovation, it is important not only to explore how IC as a whole is associated with organizations’ innovative performance but also to gain a deep understanding of the role of different IC components (groups of intangibles) in companies’ innovation performance, which is the purpose of this paper in the context of Serbian companies.Design/methodology/approachThis research is based on survey data collected from 100 Serbian companies with at least 100 employees during 2014/2015. Six IC components were analyzed (human, structural, internal relational, external relational, renewal and entrepreneurial) in terms of their effect on innovation performance. Analyses were conducted using structural equation modeling and correlation analysis.FindingsFindings demonstrate that renewal capital, internal relational capital and structural capital have statistically significant positive effects on overall innovative performance in Serbian companies.Practical implicationsThe outcomes reveal potential and barriers within IC that are crucial to innovation performance in Serbian companies. In this way, this study enables a deeper understanding of intangible drivers of innovation and highlights possibilities to foster intangible innovation potential in Serbian companies.Originality/valueAs context (economic and cultural) has emerged as a relevant factor in researching IC, this study is original in investigating IC effect on innovation within the Serbian business environment. Additionally, the broad sexpartite taxonomy of IC contributes to a wider understanding of knowledge and its linkages to innovation.
Predicting online repurchase intentions with e-satisfaction as mediator: a study on Gen Y
Authors: Trivedi Shrawan Kumar , Yadav Mohit 
Published: July 2018

PurposeShopping online is a fast-growing phenomenon. A look into the rapid exponential growth of the primary players in this sector shows huge market potential for e-commerce. Given the convenience of internet shopping, e-commerce is seen as an emerging trend among consumers, specifically the younger generation (Gen Y). The popularity of e-commerce and online shopping has captured the attention of e-retailers, encouraging researchers to focus on this area. This paper aims to examine the relationship between online repurchase intention and other variables such as security, privacy concerns, trust and ease of use (EOU), mediated by e-satisfaction.Design/methodology/approachA self-administered survey method is used, and students aged between 20 and 35 years at universities in northern India are selected as subjects. To test the hypotheses of this study, an online questionnaire is distributed to participants, with 309 legitimate responses received. The data are analyzed using SPSS version 20.0 and AMOS version 20.0. Structural equation modeling is used to examine the model and to test the hypotheses.FindingsThe results of this study show that security, privacy concerns, trust and EOU have a positive significant relationship with repurchase intention. The findings also reveal that e-satisfaction has a full mediation effect between security and repurchase intention and also between trust and repurchase intention. In addition, a partial mediation effect of e-satisfaction is noted between EOU and repurchase intention and between privacy concerns and repurchase intention.Practical implicationsThe results show that security, trust, EOU and privacy concerns are the factors that have most impact on consumer purchasing behavior. In terms of the repurchase intention of Gen Y consumers, what is needed are strong security features, an easy-to-use interface, a trusted privacy policy and the creation of trust. Furthermore, it may be beneficial to observe e-satisfaction as a mediator when identifying potential problems; online satisfaction is important for the group in this study, and the results show that it impacts on the relation between repurchase intention and other factors.Social implicationsIn terms of the repurchase intention of Gen Y consumers, what is needed are strong security features, an easy-to-use interface, a trusted privacy policy and the creation of trust. Furthermore, it may be beneficial to observe e-satisfaction as a mediator when identifying potential problems; online satisfaction is important for the group in this study, and the results show that it impacts on the relation between repurchase intention and other factors.Originality/valueThis research determines the impact of security, privacy concerns, EOU and trust on the online repurchasing behavior of Gen Y in India. The mediation effect of e-satisfaction is also determined.
Synovial GATA1 mediates rheumatoid arthritis progression via transcriptional activation of NOS2 signaling
Authors: Liu Huan , Wei Shu‐Ping , Zhi Li‐Qin , Liu Li‐Ping , Cao Tuan‐Ping , Wang Su‐Zhi , Chen Qing‐Ping , Liu Dan 
Published: July 2018

ABSTRACTTranscriptional regulation of inducible nitric oxide synthase (iNOS) is critically involved in the pathogenesis and progression of rheumatoid arthritis (RA); however, the specific transcription factors that control this process remain largely unidentified. In the present study, it was discovered that expression of the key erythroid factor, globin transcription factor 1 (GATA1), is significantly greater in human RA synovial tissues than in osteoarthritis (OA) tissues. IL 6 was found to induce synovial GATA1 expression in a signal transducer and activator of transcription 3‐dependent manner. Functionally, knockdown of GATA1 expression using specific small interfering RNA treatment was found to compromise immunoreaction‐elicited expression of proinflammatory cytokines and thus impair invasiveness of the human fibroblast‐like synovial cell line MH7A, whereas introduction of exogenous GATA1 was found to promote production of proinflammatory cytokines, leading to greater aggressiveness of MH7A cells. Mechanistically, GATA1 acts as the transcriptional coactivator of NOS2 (the gene encoding iNOS) transcription. Collectively, these data suggest that synovial GATA1 is an essential contributor to development and exacerbation of RA, presumably by inducing NOS2 transcription.
DNA Barcoding in Forensic Entomology – Establishing a DNA Reference Library of Potentially Forensic Relevant Arthropod Species,
Authors: Chimeno Caroline , Morinière Jérôme , Podhorna Jana , Hardulak Laura , Hausmann Axel , Reckel Frank , Grunwald Jan E. , Penning Randolph , Haszprunar Gerhard 
Published: July 2018

AbstractThroughout the years, DNA barcoding has gained in importance in forensic entomology as it leads to fast and reliable species determination. High‐quality results, however, can only be achieved with a comprehensive DNA barcode reference database at hand. In collaboration with the Bavarian State Criminal Police Office, we have initiated at the Bavarian State Collection of Zoology the establishment of a reference library containing arthropods of potential forensic relevance to be used for DNA barcoding applications. CO1‐5P’ DNA barcode sequences of hundreds of arthropods were obtained via DNA extraction, PCR and Sanger Sequencing, leading to the establishment of a database containing 502 high‐quality sequences which provide coverage for 88 arthropod species. Furthermore, we demonstrate an application example of this library using it as a backbone to a high throughput sequencing analysis of arthropod bulk samples collected from human corpses, which enabled the identification of 31 different arthropod Barcode Index Numbers.
First report of foregut microbial community in proboscis monkeys: are diverse forests a reservoir for diverse microbiomes?
Authors: Hayakawa Takashi , Nathan Senthilvel K. S. S. , Stark Danica J. , Saldivar Diana A. Ramirez , Sipangkui Rosa , Goossens Benoit , Tuuga Augustine , Clauss Marcus , Sawada Akiko , Fukuda Shinji , Imai Hiroo , Matsuda Ikki 
Published: July 2018

SummaryForegut fermentation is well known to occur in a wide range of mammalian species and in a single bird species. Yet, the foregut microbial community of free‐ranging, foregut‐fermenting monkeys, that is, colobines, has not been investigated so far. We analysed the foregut microbiomes in four free‐ranging proboscis monkeys (Nasalis larvatus) from two different tropical habitats with varying plant diversity (mangrove and riverine forests), in an individual from a semi‐free‐ranging setting with supplemental feeding, and in an individual from captivity, using high‐throughput sequencing based on 16S ribosomal RNA genes. We found a decrease in foregut microbial diversity from a diverse natural habitat (riverine forest) to a low diverse natural habitat (mangrove forest), to human‐related environments. Of a total of 2700 bacterial operational taxonomic units (OTUs) detected in all environments, only 153 OTUs were shared across all individuals, suggesting that they were not influenced by diet or habitat. These OTUs were dominated by Firmicutes and Proteobacteria. The relative abundance of the habitat‐specific microbial communities showed a wide range of differences among living environments, although such bacterial communities appeared to be dominated by Firmicutes and Bacteroidetes, suggesting that those phyla are key to understanding the adaptive strategy in proboscis monkeys living in different habitats.
A systematic review of local excision followed by adjuvant therapy in early rectal cancer: are pT1 tumours the limit?
Authors: Cutting J. E. , Hallam S. E. , Thomas M. G. , Messenger D. E. 
Published: July 2018

AbstractAimTotal mesorectal excision remains the cornerstone of treatment for rectal cancer. Significant morbidity means local excision may be more appropriate in selected patients. Adjuvant therapy reduces local recurrence and improves survival; however, there is a paucity of data on its impact following local excision, which this systematic review aims to address.MethodsA systematic search of the MEDLINE, Embase and Cochrane databases using validated terms for rectal cancer, adjuvant therapy and local excision was performed. Included studies focused on local excision with adjuvant therapy for adenocarcinoma of the rectum. Primary outcome measures were local recurrence, survival and morbidity. Studies providing neoadjuvant therapy or local excision alone were excluded.ResultsTwenty‐two studies described 804 patients. Indications for local excision included favourable histology, patient choice and comorbidities. T1, T2 and T3 tumours accounted for 35.1%, 58.0% and 6.9% of cases, respectively. The most frequent local excision technique was transanal excision (77.7%). Adjuvant therapy included long‐course chemoradiation or radiotherapy. Median follow‐up was 51 months (range 1–165). The pooled local recurrence was 5.8% (95% CI 3.0–9.5) for pT1, 13.8% (95% CI 10.1–17.9) for pT2 and 33.7% (95% CI 19.2–50.1) for pT3 tumours. The overall median disease‐free survival was 88% (range 50%–100%) with a pooled overall morbidity of 15.1% (95% CI 11.0–18.7).ConclusionsThis area remains highly relevant to modern clinical practice. The data suggest that local excision followed by adjuvant therapy can achieve acceptable long‐term outcomes in high‐risk pT1 tumours, but not in T2 tumours and above in whom radical surgery should be offered.
Associations of community programs and policies with children's dietary intakes: the Healthy Communities Study
Authors: Ritchie L. D. , Woodward‐Lopez G. , Au L. E. , Loria C. M. , Collie‐Akers V. , Wilson D. K. , Frongillo E. A. , Strauss W. J. , Landgraf A. J. , Nagaraja J. , Sagatov R. D. F. , Nicastro H. L. , Nebeling L. C. , Webb K. L. ,   on behalf of the Healthy Communities Study Team
Published: July 2018

SummaryBackgroundThe impact of community‐based obesity prevention efforts on child nutrition has not been adequately studied.ObjectiveExamine relationships between number, type and intensity of community programs and policies (CPPs) and child nutrition.MethodsAn observational study of 5138 children (grades K–8) in 130 U.S. communities was conducted in 2013–2015. CPPs were identified by 10–14 key informant interviews per community. CPPs were characterized based on: count, intensity, number of different strategies used and number of different behaviours targeted. Scores for the prior 6 years were calculated separately for CPPs that addressed primarily nutrition, primarily physical activity (PA) or total combined. Child intakes were calculated from a dietary screener and dietary behaviours were based on survey responses. Multi‐level statistical models assessed associations between CPP indices and nutrition measures, adjusting for child and community‐level covariates.ResultsImplementing more types of strategies across all CPPs was related to lower intakes of total added sugar (when CPPs addressed primarily PA), sugar‐sweetened beverages (for nutrition and PA CPPs) and energy‐dense foods of minimal nutritional value (for total CPPs). Addressing more behaviours was related to higher intakes of fruit and vegetables (for nutrition and total CPPs) and fibre (total CPPs). Higher count and intensity (PA and total CPPs) were related to more consumption of lower fat compared with higher fat milk. A higher count (PA CPPs) was related to fewer energy‐dense foods and whole grains. No other relationships were significant atP < 0.05.ConclusionMultiple characteristics of CPPs to prevent obesity appear important to improve children's diets.
Solid‐phase extraction treatment is required for measurement of active glucagon‐like peptide‐1 by enzyme‐linked immunosorbent assay kit affected by heterophilic antibodies
Authors: Hasegawa Tomonori , Komagata Miho , Hamasaki Akihiro , Harada Norio , Seino Yutaka , Inagaki Nobuya 
Published: July 2018

AbstractAims/IntroductionIt is reported that interfering substances in the blood might influence the value for measurement of active glucagon‐like peptide‐1 (GLP‐1) in human plasma. Solid phase extraction (SPE) pretreatment is recommended to reduce their influence, but it requires a lot of cost and time. However, there is little investigation about causative inhibitory substances and about methods that can replace solid phase extraction. In the present study, we aimed to seek the candidate of the substances that might interfere with an active GLP‐1 enzyme‐linked immunosorbent assay (ELISA).Materials and MethodsTwo kinds of active GLP‐1 ELISA kits using different antibodies, plural extraction carriers and elution solutions were used to evaluate the SPE method. Active GLP‐1 concentration was compared with or without SPE, and with or without a heterophilic blocking tube.ResultsActive GLP‐1 values were often higher without SPE compared with those with SPE pretreatment. This difference was eliminated by pretreatment with a heterophilic blocking tube or ELISA kits that did not use a mouse monoclonal antibody, and was independent of SPE.ConclusionsSubstances absorbed to a heterophilic blocking tube carrier might interfere with an active GLP‐1 immunoassay. Solid‐phase extraction treatment is required for measurement of active GLP‐1 by an ELISA kit affected by heterophilic antibodies.
Direct medical cost of diabetes in rural China using electronic insurance claims data and diabetes management data
Authors: Wu Haibin , Eggleston Karen N , Zhong Jieming , Hu Ruying , Wang Chunmei , Xie Kaixu , Chen Yiwei , Chen Xiangyu , Yu Min 
Published: July 2018

AbstractAims/IntroductionTo evaluate the annual direct medical cost attributable to type 2 diabetes mellitus according to socioeconomic factors, medical conditions and complications categories.Materials and MethodsWe created uniquely detailed data from merging datasets of the local diabetes management system and the social security system in Tongxiang, China. We calculated the type 2 diabetes mellitus‐related total cost and out‐of‐pocket cost for inpatient admissions and outpatient visits, and compared the cost for patients with or without complications by different healthcare items.ResultsA total of 16,675 patients were eligible for analysis. The type 2 diabetes mellitus‐related cost accounted for 40.6% of the overall cost. The cost per patient was estimated to be a median of 1,067 Chinese Yuan, 7,114 Chinese Yuan and 969 Chinese Yuan for inpatient and outpatient cost, respectively. The median total cost for hospital‐based care was 3.69‐fold higher than that for primary care. The median cost of patients with complications was 3.46‐fold higher than that of those without complications. The median cost for a patient with only macrovascular, only microvascular or both macrovascular and microvascular complications were 3.13‐, 3.79‐ and 10.95‐fold higher than that of patients without complications. Pharmaceutical expenditure accounted for 51.8 and 79.7% of the total cost for patients with or without complications, respectively.ConclusionsAlthough the type 2 diabetes mellitus‐related cost per patient was relatively low, it accounted for a great proportion of the overall cost. Complications obviously aggravated the economic burden of type 2 diabetes mellitus. Proper management and the prevention of diabetes and its complications are urgently required to curtail the economic burden.
Factors influencing sessions' and speakers' evaluation: an analysis of seven consecutive European Academy of Dermatology and Venereology congress editions
Authors: Cazzaniga S. , Scerri L. , Gabbud J.P. , Arenberger P. , Borradori L. , Naldi L. 
Published: July 2018

AbstractBackgroundThe variables affecting participants' satisfaction with a scientific conference in dermatology have not been systematically assessed. The European Academy of Dermatology and Venereology (EADV) has collected a huge number of questionnaires related to sessions' and speakers' evaluation over the years. The critical analysis of satisfaction's score is important and helpful for continuous improvement of the scientific programming.ObjectiveTo identify factors that positively or negatively affect sessions' and speakers' scoring in the largest European congress of dermatology.MethodsThis was a retrospective analysis of all sessions' evaluation forms collected between 2009 and 2015 during seven consecutiveEADVcongresses. A predictive model for sessions' and another for speakers' score evaluation were built based on multivariate linear regression.ResultsOverall, 4964 speakers and 1022 sessions were evaluated. Topics more positively associated with total sessions' scoring were as follows: dermoscopy, neutrophilic diseases and hidradenitis suppurativa. Conversely, types of sessions which considerably negatively associated with total sessions' scoring included short thematic presentations and free communications. Furthermore, types of sessions which were more positively associated with high total speakers' scoring consisted of focus sessions and plenary lectures, whereas the most appreciated topics encompassed dermoscopy, screening programs, melanocytic naevi, panniculitis, organ transplanted and immunosuppressed patients, neutrophilic diseases, dermatopathology and history of dermatology. Finally, short thematic presentations, free communications and guidelines session showed overall poor scores.ConclusionFocused and specialized topics are more prone to capture attention of participants when compared to sessions of heterogeneous content. Quite surprisingly, a practice‐oriented topics such as guidelines, did not achieve a high score. Our findings provide new knowledge about components, which increase the level of satisfaction of participants and should facilitate the programming of attractive scientific congresses associated with increased training satisfaction.
Bacterascites: A study of clinical features, microbiological findings, and clinical significance
Authors: Oey Rosalie C. , van Buuren Henk R. , de Jong David M. , Erler Nicole S. , de Man Robert A. 
Published: July 2018

AbstractBackgroundKnowledge about bacterascites is limited and management guidelines are based on small patient series. The purpose of this study was to add further insight into the clinical characteristics, microbiological findings, and prognosis of patients diagnosed with bacterascites.MethodsRetrospective analysis of patients with advanced chronic liver disease diagnosed with bacterascites and SBP between January 2003 and August 2016.ResultsIn this study, 123 patients were included with 142 episodes of bacterascites. The median MELD score was 20 and clinical symptoms of infection were present in 78%. Empiric antibiotic treatment was initiated in 68%. In 26 untreated patients undergoing repeated paracentesis, 42% were diagnosed with either ongoing bacterascites or SBP. The presence of signs or symptoms of infection was not an independent predictor for mortality or spontaneous resolution of infection. The 1‐month and 1‐year mortality rates of the 123 patients studied, were 32% and 60%, respectively; these results were in line with data pertaining to the prognosis of SBP.ConclusionsPatients with bacterascites and SBP are highly comparable with respect to severity of liver disease and overall prognosis. If left untreated, bacterascites is likely to persist or to evolve to SBP in a significant proportion of patients. The results of this study support current guidelines regarding the treatment of ascitic fluid infection, but could not confirm the prognostic relevance of symptomatic disease at the time of diagnosis. We suggest that the threshold to initiate antibiotic treatment, in particular in cases with severely advanced liver disease, should be low.
Threshold of motion and settling velocities of mollusc shell debris: Influence of faunal composition
Authors: Rieux Alissia , Weill Pierre , Mouaze Dominique , Poirier Clement , Nechenache Farid , Perez Laurent , Tessier Bernadette 
Published: July 2018

AbstractBioclastic particles derived from mollusc shell debris can represent a significant fraction of sandy to gravelly sediments in temperate and cool‐water regions with high carbonate productivity. Their reworking and subsequent transport and deposition by waves and currents is highly dependent on the shape and density of the particles. In this study, the hydrodynamic behaviour of shell debris produced by eight mollusc species is investigated for several grain sizes in terms of settling velocity (measurements in a settling tube) and threshold of motion under unidirectional current (flume experiments using an acoustic profiler). Consistent interspecific differences in settling velocity and critical bed shear stress are found, related to differences in shell density, shell structure imaged by scanning electron microscopy and grain shape. Drag coefficients are proposed for each mollusc species, based on an interpolation of settling velocity data. Depending on the shell species, the critical bed shear stress values obtained for bioclastic particles fall within or slightly below empirical envelopes established for siliciclastic particles, despite very low settling velocity values. The results suggest that settling velocity, often used to describe the entrainment of sediment particles through the equivalent diameter, is not a suitable parameter to predict the initiation of motion of shell debris. The influence of the flat shape of bioclastic particles on the initiation of motion under oscillatory flows and during bedload and saltation transport is yet to be elucidated.