bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Screening for Anti-inflammatory Bioactive Molecules from Ayurvedic Decoction, Balaguluchyadi kashayam
Authors: S. J. Rahitha Devi , Kumar B. Prakash 
Published: October 2019

Background:
Balaguluchyadi kashayam, a polyherbal Ayurvedic decoction prepared
from Sidacordifolia L., Tinospora cordifolia (Willd.) Miers, and Cedrusdeodara (Roxb. ex D.Don)
G.Don, is used in Ayurveda for the treatment of chronic inflammatory conditions. Although this
herbal decoction has been used for a long period for treating chronic inflammatory conditions, the
mechanism of action of the decoction in reducing inflammatory conditions associated with chronic
inflammation has not been clearly understood. Mass spectroscopy-based identification of bioactive
molecules present in the decoction and its interaction with enzymes/proteins involved in the pathogenesis
of chronic inflammation has been carried and reported in this study.

Introduction:
Polyherbalism is one of the major principles of Ayurveda. Various phytoconstituents
with different activities in the polyherbal decoction act on multi targets of a wide range of diseases.
Balaguluchyadi kashayam is a polyherbal decoction prescribed for chronic inflammatory etiologies
and the present study aims to evaluate the binding potential of the compounds, identified from
Balaguluchyadi kashayam to enzymes/proteins involved in the development and progression of
chronic inflammation.

Methods:
The bioactive compounds present in the Balaguluchyadi Kashayam fractions were extracted
by preparative HPLC and identified using UPLC MS Q-TOF. The physicochemical characteristics
and ADMET properties of the compounds were calculated using Mol soft, Swiss ADME
and OSIRIS data warrior software. Then the binding interactions between the molecules and the
proinflammatory mediators such as 5 Lipoxygenase, Cyclooxygenase 2, Tumor necrosis factoralpha
convertase enzyme (TACE) and Caspase 1 were determined using molecular docking software
Auto Dock 4.0 (http://autodock.scripps.edu/downloads).

Results:
The identified bioactive molecules in the decoction showed a good binding affinity towards
the enzymes/proteins involved in the development and progression of chronic inflammation
compared to the binding affinity of known inhibitors/drugs to the respective enzymes/proteins.

Conclusion:
The bioactive molecules identified in Balaguluchyadi Kashayam could be developed
as potential therapeutic molecules against enzymes/proteins involved in the development and progression
of chronic inflammation.
The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective
Authors: Caiati Carlo , Pollice Paolo , Favale Stefano , Lepera Mario Erminio 
Published: October 2019

Background::
Glyphosate (G) is the most common weed-killer in the world. Every year tons
and tons of G are applied on crop fields. G was first introduced in the mid 1970s and since then its
usage has gradually increased to reach a peak since 2005. Now G usage is approximately 100 -fold
what it was in 1970. Its impact on human health was considered benign at the beginning. But over the
years, evidence of a pervasive negative effect of this pesticide on humans has been mounting. Nonetheless,
G usage is allowed by government health control agencies (both in the United States and Europe),
that rely upon the evidence produced by the G producer. However, the IARC (International Agency for
Research on Cancer) in 2015 has stated that G is probable carcinogenic (class 2A), the second highest
class in terms of risk.

Objective::
In this review, we explore the effect of G on human health, focusing in particular on more
recent knowledge.

Results::
We have attempted to untangle the controversy about the dangers of the product for human
beings in view of a very recent development, when the so -called Monsanto Papers, consisting of
Emails and memos from Monsanto came to light, revealing a coordinated strategy to manipulate the
debate about the safety of glyphosate to the company’s advantage.

Conclusions::
The story of G is a recurrent one (see the tobacco story), that seriously jeopardizes the
credibility of the scientific study in the modern era.
The Importance of Reflection: An Exploratory Analysis on How Prospective Psychotherapists Learn Self-Determination
Authors: Nurmi Bo , Michelsen Clive S. , Norlander Torsten 
Published: October 2019

Background:
Learning to become a psychotherapist is a complicated process. Research on this topic has been limited and there is little consensus on how to assess therapeutic skills. SP/SR (Self-Reflection/Self-Practice) has emerged as a theory and method for learning psychotherapy. In this article students' reflections on how to become a psychotherapist has been studied from a phenomenological perspective.

Objective:
The aim of the present exploratory study was to generate preliminary hypotheses for future investigations in order to elucidate the complicated processes that occur during the therapist training programs.

Methods:
Five prospective psychotherapists were recruited to the present investigation, who all studied at the penultimate semester at Evidens University College, Gothenburg, Sweden. Unstructured qualitative in-depth interviews were used followed by phenomenological analysis.

Results:
Analysis yielded 252 meaning units and 12 categories which in turn led to four overarching themes: Learning as a visit to the dentist (when learning becomes painful because certain issues are not resolved); Learning as theatre (when the students just perform what is expected in order to pass); Learning as post-training soreness (when the learning process is challenging on a relevant level); Learning as reflections (when the students seek the intrinsic meaning).

Conclusion:
The study provided a basis for preliminary hypotheses for future investigations: reflections are helpful for managing the challenges described in the four themes. This, in turn, led to the formulation of some proposals for research questions for future investigations.
The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence
Authors: Trubitsyn Alexander G. 
Published: October 2019

Background:Accumulation of various damages is considered the primary cause of aging throughout the history of gerontology. No progress has been made in extending animal lifespan under the guidance of this concept. This concept denies the existence of longevity genes, but it has been experimentally shown that manipulating genes that affect cell division rates can increase the maximum lifespan of animals. These methods of prolonging life are unsuitable for humans because of dangerous side effects, but they undoubtedly indicate the programmed nature of aging.Objective:The objective was to understand the mechanism of programmed aging to determine how to solve the problem of longevity.Methods:Fundamental research has already explored key details relating to the mechanism of programmed aging, but they are scattered across different fields of knowledge. The way was to recognize and combine them into a uniform mechanism.Results:Only a decrease in bioenergetics is under direct genetic control. This causes many different harmful processes that serve as the execution mechanism of the aging program. The aging rate and, therefore, lifespan are determined by the rate of cell proliferation and the magnitude of the decrease in bioenergetics per cell division in critical tissues.Conclusion:The mechanism of programmed aging points the way to achieving an unlimited healthy life; it is necessary to develop a means for managing bioenergetics. It has already been substantially studied by molecular biologists and is now waiting for researchers from gerontology.
Towards an Aesthetic Space: A Comparative Study
Authors: Reid Jonathan 
Published: October 2019

This article aims to explore, through a literature review, what may be termed ‘the aesthetic space’ and to draw comparison with dialogical theories. The word ‘aesthetic’ literally means to take in the world through the senses. The study is based on theories and related principles from the fields of education, philosophy and psychology and from those of the world of the creative arts in determining what is meant by ‘the aesthetic space’. Simultaneously, comparison is drawn towards an aesthetic approach to communication and dialogical theory. To enter the ‘aesthetic space’ is to engage creatively with the senses and the process of meaning making.
Besides a literature description, the study examines, through focus groups, questionnaires and video-analysis tasks, the I-positions of two groups of professionals (support and art workers) in analysing communicative agency in a deafblind/non-deafblind dyad engaging in an ‘aesthetic space encounter’. Creative approaches are recommended for people with deafblindness and their social partners to develop agency within communication in the deafblind field.
https://doi.org/10.21827/jdbsc.5.32573
Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study
Authors: Vantyghem Marie-Christine , Chetboun Mikael , Gmyr Valéry , Jannin Arnaud , Espiard Stéphanie , Le Mapihan Kristell , Raverdy Violeta , Delalleau Nathalie , Machuron François , Hubert Thomas , Frimat Marie , Van Belle Eric , Hazzan Marc , Pigny Pascal , Noel Christian , Caiazzo Robert , Kerr-Conte Julie , Pattou François ,   on behalf of the working groups Diaménord, G4, and Platform of Biotherapy
Published: October 2019

OBJECTIVE
The long-term outcome of allogenic islet transplantation is unknown. The aim of this study was to evaluate the 10-year outcome of islet transplantation in patients with type 1 diabetes and hypoglycemia unawareness and/or a functioning kidney graft.

RESEARCH DESIGN AND METHODS
We enrolled in this prospective parallel-arm cohort study 28 subjects with type 1 diabetes who received islet transplantation either alone (ITA) or after a kidney graft (IAK). Islet transplantation consisted of two or three intraportal infusions of allogenic islets administered within (median [interquartile range]) 68 days (43–92). Immunosuppression was induced with interleukin-2 receptor antibodies and maintained with sirolimus and tacrolimus. The primary outcome was insulin independence with A1C ≤6.5% (48 mmol/mol). Secondary outcomes were patient and graft survival, severe hypoglycemic events (SHEs), metabolic control, and renal function.

RESULTS
The primary outcome was met by (Kaplan-Meier estimates [95% CI]) 39% (22–57) and 28% (13–45) of patients 5 and 10 years after islet transplantation, respectively. Graft function persisted in 82% (62–92) and 78% (57–89) of case subjects after 5 and 10 years, respectively, and was associated with improved glucose control, reduced need for exogenous insulin, and a marked decrease of SHEs. ITA and IAK had similar outcomes. Primary graft function, evaluated 1 month after the last islet infusion, was significantly associated with the duration of graft function and insulin independence.

CONCLUSIONS
Islet transplantation with the Edmonton protocol can provide 10-year markedly improved metabolic control without SHEs in three-quarters of patients with type 1 diabetes, kidney transplanted or not.
Trends in Rates of Infections Requiring Hospitalization Among Adults With Versus Without Diabetes in the U.S., 2000–2015
Authors: Harding Jessica L. , Benoit Stephen R. , Gregg Edward W. , Pavkov Meda E. , Perreault Leigh 
Published: October 2019

OBJECTIVE
Vascular complications of diabetes have declined substantially over the past 20 years. However, the impact of modern medical treatments on infectious diseases in people with diabetes remains unknown.

RESEARCH DESIGN AND METHODS
We estimated rates of infections requiring hospitalizations in adults (≥18 years) with versus without diabetes, using the 2000–2015 National Inpatient Sample and the National Health Interview Surveys. Annual age-standardized and age-specific hospitalization rates in groups with and without diabetes were stratified by infection type. Trends were assessed using Joinpoint regression with the annual percentage change (Δ%/year) reported.

RESULTS
In 2015, hospitalization rates remained almost four times as high in adults with versus without diabetes (rate ratio 3.8 [95% CI 3.8–3.8]) and as much as 15.7 times as high, depending on infection type. Overall, between 2000 and 2015, rates of hospitalizations increased from 63.1 to 68.7 per 1,000 persons in adults with diabetes and from 15.5 to 16.3 in adults without diabetes. However, from 2008, rates declined 7.9% in adults without diabetes (from 17.7 to 16.3 per 1,000 persons; Δ%/year −1.5, P &lt; 0.01), while no significant decline was noted in adults with diabetes. The lack of decline in adults with diabetes in the later period was driven by significant increases in rates of foot infections and cellulitis as well as by lack of decline for pneumonia and postoperative wound infections in young adults with diabetes.

CONCLUSIONS
Findings from this study highlight the need for greater infectious risk mitigation in adults with diabetes, especially young adults with diabetes.
PAKOM PETERNAK PUYUH DESA GAJAHAN COLOMADU KARANGANYAR
Authors: Hakim Lukman , Hanwar Dedi , Sugiyanto Eko , Irawati Zulfa 
Published: October 2019

The purpose of this activity is improving knowledge and skill of quail farmer’s in waste management of quail. The management of waste is processing of organic fertilizer. The participate in the activity are quail farmer’s in RW II Sub-village Ginung, Gajahan Village, Colomadu, Karanganyar. The result of this activity in step I that is be good attention from a quail farmer’s especiality at trainning time process of product organic fertilizer. As for its result as follows; trainning and assistence quail farmer’s is followed enthusiastic fully by participant and greeted positive by head of Village Gajahan Colomadu, Karanganyar. That are many question in trainning process of product organic fertilizer. The others result in activity is a quail farmer’s started processing of product organic fertilizer in housebreed themselves. The processing of product organic fertilizer will be clean in Gajahan Village environment and also this activity will be value added toward income quail farmer’s.
Addressing Air Pollution And Beyond In Ulaanbaatar: The Role Of Sustainable Mobility
Authors: Aschmann Marion 
Published: October 2019

All over the world the transport sector contributes to local air pollution as well as CO2 -emissions and transportation related problems such as congestion especially in urban agglomerations. In Ulaanbaatar traffic is currently not the most important source of air pollution but it will gain importance due to a growing demand for transport and related effects. A transformation towards sustainable mobility is therefore needed which is pursued by reduction of the number of trips, influencing the modal split towards more sustainable modes and more efficient handling of mobility.This paper discusses different characteristics of air pollution, traffic congestion and CO2 - emissions and respective suitability of policy instruments. It is argued that conducting mobility more efficient will be not enough to address all relevant effects of growing demand. In doing so special attention is given to the interaction of built environment, land use and transport as well as related planning approaches which is particularly important in a situation when urban growth has to be managed.A transfer towards sustainable mobility needs a two-step approach: a more short-term improvement related to a more environmentally friendly transport system and a longterm approach to organise urban mobility in a sustainable way by adopting an integrated urban and transport planning and influencing transport behaviour.
Multipurpose National Forest Inventory in Mongolia, 2014-2017 -A tool to support sustainable forest management
Authors: Altrell Dan 
Published: October 2019

Mongolia’s first Multipurpose National Forest Inventory, 2014-2017, was implemented by the Forest Research and Development Centre, in collaboration with international expertise and the country’s main forestry institutions, universities and research organisations.The long-term objective of the multipurpose NFI is to promote sustainable management of forestry resources in Mongolia, to enhance their social, economic and environmental functions.The NFI findings show that there are 11.3 million hectares of Boreal Forest in Mongolia. 9.5 million hectares are Stocked Boreal Forest Area, of which 69 percent is located outside of protected areas, 4 percent are designated for green-wood utilisation through forest enterprise concessions, and another 16 percent designated for fallen dead-wood collection through forest user group concessions. The non-protected stocked forests (i.e. production forest) have an average growing stock volume of 115 m3 per hectare, compared with an optimal growing stock volume of 237 m3 per hectare, and there is an additional 46.5 m3 of dead wood per hectare. The growing stock age distribution shows that 24 m3 per hectare are over 200 years (i.e. economically over-aged). The main tree species in stocked forest are Larix sibirica (81%), Pinus sibirica (7%), Betula platyphylla (6%) and Pinus sylvestris (5%), of which all, except for P. sibirica, are classified as legally harvestable tree species. Wild fire is the current main environmental factor decreasing the forest tree biomass.The NFI helped identifying priority areas for the forestry sector, and to guide the implementation of sustainable forest management at the local level. The main forest management challenges of Mongolia’s boreal forest will be to address that they are a) under-stocked (less than 50% of production potential), b) over-aged (31% of growing stock volume in stocked production forest is above optimal production age), and c) under-utilised (4% of forest area designated to green-wood utilisation).
THE PREFACIAL DISCOURSE OF THE BILINGUAL FRENCH-ROMANIAN/ROMANIAN-FRENCH 19TH CENTURY DICTIONARIES
Authors: GENCĂRĂU Oana Aurelia , GENCĂRĂU Ștefan 
Published: October 2019

The Prefacial Discourse of the bilingual French-Romanian/ Romanian-French 19th Century Dictionaries. We systematically return to our 19th century bilingual lexicography, and this time we turn towards textual sequences preceding the respective lexicographic body; these are interesting for those seeking to understand how the practice of dictionary compilation has evolved; these textual sequences, be they the preface or the inscription, show the way the configuration discourse of a lexicographical work comes, little by little, to confirm the presence of the model, to claim the method and to subordinate the undertaking of the interest of one or several categories of addressees.
Rezumat. Discursul prefațial al dicționarelor bilingve francezo-române/ româno-franceze din secolul al XIX-lea. Revenim sistematic la lexicografia noastră bilingvă din secolul al XIX-lea și ne îndreptăm de data aceasta spre secvențe textuale ce precedă corpul lexicografic respectiv ; acestea prezintă interes pentru cel ce dorește să înțeleagă cum au evoluat practicile de alcătuire a dicționarelor; aceste secvențe textuale, fie că e vorba de prefață, fie că e vorba de dedicații, arată cum discursul de configurare a unei opere lexicografice ajunge, încetul cu încetul, să confirme prezența modelului, să reclame metoda și să-și subordoneze întreprinderea interesului unui sau unor categorii de destinatari.
Cuvinte cheie: vocabular, dicționar bilingv, prefață, dedicație, lexicografie bilingvă.
Shear strength of compacted Chlef sand: effect of water content, fines content and others parameters
Authors: Bouri Djamel , Krim Abdallah , Brahim Abdelkader , Arab Ahmed 
Published: October 2019

Abstract
This paper presents a laboratory study of the combined effect of the water content and fines content on the mechanical behaviour of Chlef sand in a medium dense state (RD = 65%) and dense state (RD = 80%). Several mechanical parameters were evaluated such as shear strength, cohesion and friction angle at different water content w = 0, 1, 2 and 3% and different fines content Fc = 0, 10, 20, 30 and 40%. The test results showed that the shear strength of Chlef sand decrease with the increase fines content Fc = 0 to 40%, our tests result also showed that the water content has a significant influence on the shear strength which decreases with the increase in the water content w = 0 to 3%. The fines content and the water content have a significant influence on the mechanical parameters c and φ. Cohesion increases with the percentage of fines and decreases with the increase of the water content while the friction angle decreases with the increase the fines content and the water content.
PENGARUH PEMANFAATAN TEKNOLOGI, KOMPETENSI SUMBER DAYA MANUSIA DAN KOMITMEN ORGANISASI TERHADAP KUALITAS LAPORAN KEUANGAN SKPA PROVINSI ACEH
Authors: Pratama Rian Rezky , Yahya M. Rizal 
Published: October 2019

The research examines the influence of The Use of Information Technology (PT), Human Resources Competence (SDM) and Organizational Commitment (KO) on the Quality of the financial statements (KLK). The population in this study is SKPA of Aceh Province. The sampling technique used is simple random sampling. This study uses primary data which obtained through the questionnaire results. The data were colleccted 63 questionnaires from 35 SKPA. Data were processed using SPSS version 22 and analyzed using multiple linear regression, F-Test, and t-test. The results show that simultaneously, The Use of Information Technology (PT), Human Resources Competence (SDM) and Organizational Commitment (KO) affect the Quality of the financial statements (KLK). Partially, each independent variable affect Quality of the financial statements.
Abnormal Joint Loading During Gait in Persons With Hip Osteoarthritis Is Associated With Symptoms and Cartilage Lesions
Authors: Liao Tzu-Chieh , Samaan Michael A. , Popovic Tijana , Neumann Jan , Zhang Alan L. , Link Thomas M. , Majumdar Sharmila , Souza Richard B. 
Published: October 2019

Background Hip joint loading in persons with hip osteoarthritis (OA) is not well studied, and its associations with symptoms and lesions are unknown. Objectives To determine whether hip joint loading differs between people with and without radiographic hip OA, and to identify its associations with patients' symptoms and cartilage morphology. Methods Forty-eight patients (28 male; mean ± SD age, 56.0 ± 12.2 years) with hip OA and 95 controls (40 male; age, 43.2 ± 13.6 years) participated in this cross-sectional analysis. Pelvic radiographs, questionnaires, magnetic resonance imaging (MRI), and gait analysis were conducted. The Hip disability and Osteoarthritis Outcome Score (HOOS) was used to assess symptoms. Cartilage morphology was graded on MRI scans using the Scoring Hip Osteoarthritis with Magnetic Resonance Imaging (SHOMRI) system. Biomechanical variables included peak external hip joint moment (Newton meters per kilogram) and moment impulses (Newton meters times milliseconds per kilogram) in all planes. Generalized estimating equations were used to compare the biomechanical characteristics between groups. In the patients with OA, associations of moment impulses with HOOS and SHOMRI scores were assessed with partial correlations. Results The OA group exhibited higher peak external hip flexion and adduction moments (P<.001) and higher hip flexion, adduction, and external rotation moment impulses (P = .001–.039). Increased hip flexion moment impulses were correlated with worse HOOS subscale scores (r = −0.361 to −0.424, P<.05) and worse femoral SHOMRI grades (ρ = 0.256–0.315, P<.05). Increased hip external rotation moment impulses were correlated with worse femoral SHOMRI grades (ρ = 0.283–0.372, P<.05). Conclusion Persons with hip OA exhibited abnormally high hip joint loads during walking, and high loads were associated with worse self-reported symptoms and cartilage morphology. J Orthop Sports Phys Ther 2019;49(12):917–924. Epub 14 Oct 2019. doi:10.2519/jospt.2019.8945