bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal red blood cell alloimmunization requiring intrauterine transfusion: a comparative study on management and outcome depending on the type of antibody
Authors: Phung Thanh‐Vy , Houfflin‐Debarge Véronique , Ramdane Nassima , Ghesquière Louise , Delsalle Anne , Coulon Capucine , Subtil Damien , Vaast Pascal , Garabedian Charles 
Published: March 2018

BACKGROUNDThe antibody primarily responsible for fetal anemia may influence treatment and prognosis. The primary objective was to compare ante‐ and postnatal management and the outcomes of maternal red blood cell (RBC) alloimmunizations according to the antibody involved. The secondary objective was to compare anti‐D alloimmunizations according to associated number of antibodies.STUDY DESIGN AND METHODSA single‐center study from 1999 to 2015 including maternal RBC alloimmunizations requiring intrauterine transfusion (IUT) was conducted. Patients were classified according to the antibody involved: anti‐D, other Rh (anti‐c and anti‐E), and anti‐K1. Obstetric data, IUT characteristics, and neonatal outcome were compared. A specific study on the anti‐D, when isolated or associated, was then conducted.RESULTSThere were 106 pregnancies included, with 77.4% having anti‐D, 9.4% having another anti‐Rh (Rh group), and 13.2% having anti‐K1. No significant difference between the anti‐D and Rh groups was found for management and prognosis. The hemoglobin level in the first IUT was higher in the anti‐D group than in the Kell group (6.8 vs. 4.7 g/dL, p = 0.008). Newborns in the anti‐D group had significantly higher bilirubin levels and phototherapy duration than those in the Kell group. The mean estimated daily decrease in hemoglobin and that between the first two IUTs were lower with an isolated anti‐D, compared with anti‐D associated with two antibodies (p = 0.04).CONCLUSIONAnti‐K1 alloimmunizations seem to cause more severe fetal anemia than anti‐D alloimmunizations. Moreover, a decrease in hemoglobin appears to be more rapid when anti‐D is associated with other antibodies.
Region specific analysis for the use of ‘universal’ donor group O D− red blood cell units within Australia
Authors: Hirani R. , Wong J. , Mondy P. , Irving D. O. 
Published: March 2018

ObjectivesIn Australia, the demand for group O D− red blood cell (RBC) units is proportionally increasing in contrast with an overall reduction in RBC demand. A survey was conducted to understand the use of group O D− RBC units. Aggregated national data from this study have been reported. However, Australia has large geographical and jurisdictional differences in blood product funding arrangements, transfusion and inventory management practices. This region specific analysis was conducted to understand these differences in the use of group O D− RBC units.DesignThe fate of each O D− RBC unit issued during a 5‐week period (n = 9733) was analysed including urgency of transfusion, product age, patient demographics or reason for discard. The data were divided to represent five regions representing 1‐2 states and/or territories across Australia.ResultsRegions 1 and 5 had the lowest number of O D− RBC units issued per 1000 population. Region 4 had the lowest percentage of discard (3·8%) compared with the national average of 7·9%. Region 4 also had the lowest percentage (44·0%) of O D− RBC units transfused into nongroup O D‐ recipients compared with the national average of 52·2%.ConclusionsThe differences in usage of group O D− RBC units among regions were not statistically significant. However, possible region specific practices, such as the presence of a well‐developed blood rotation programme, could impact O D− RBC demand. Shared learning across all regions could assist in ameliorating the increasing national O D− RBC demand in Australia.
Occupational transmission of an Orthopoxvirus infection during an outbreak in a colony of Macaca tonkeana in Lazio Region, Italy, 2015
Authors: Puro V. , Fusco F. M. , Castilletti C. , Carletti F. , Colavita F. , Agrati C. , Di Caro A. , Capobianchi M. R. , Ippolito G. 
Published: March 2018

SummaryOrthopoxviruses spill over from animal reservoirs to accidental hosts, sometimes causing human infections. We describe the surveillance and infection control measures undertaken during an outbreak due to an Orthopoxvirus occurred in January 2015 in a colony of Macaca tonkeana in the province of Rieti, Latio, Italy, which caused a human asymptomatic infection. According to the epidemiological investigation, the human transmission occurred after an unprotected exposure. The contacts among wild, captive and domestic animals and humans, together with decreased immunity against Orthopoxviruses in the community, may put animal handlers at risk of infection, especially after the cessation of smallpox vaccination. To reduce these threats, standard precautions including respiratory hygiene and transmission‐based precautions should be carefully applied also in veterinary medicine.
Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species
Authors: Abastabar Mahdi , Al-Hatmi Abdullah M. S. , Vafaei Moghaddam Mohammad , de Hoog G. Sybren , Haghani Iman , Aghili Seyed Reza , Shokohi Tahereh , Hedayati Mohammad Taghi , Daie Ghazvini Roshanak , Kachuei Reza , Rezaei-Matehkolaei Ali , Makimura Koichi , Meis Jacques F. , Badali Hamid 
Published: March 2018

ABSTRACT

A collection of clinical (
n
= 47) and environmental (
n
= 79)
Fusarium
isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to
Fusarium
species.
Micafungin Breakthrough Fungemia in Patients with Hematological Disorders
Authors: Kimura Muneyoshi , Araoka Hideki , Yamamoto Hisashi , Nakamura Shigeki , Nagi Minoru , Yamagoe Satoshi , Miyazaki Yoshitsugu , Ogura Sho , Mitsuki Takashi , Yuasa Mitsuhiro , Kaji Daisuke , Kageyama Kosei , Nishida Aya , Taya Yuki , Shimazu Hiroshi , Ishiwata Kazuya , Takagi Shinsuke , Yamamoto Go , Asano-Mori Yuki , Uchida Naoyuki , Wake Atsushi , Taniguchi Shuichi , Yoneyama Akiko 
Published: March 2018

ABSTRACT

Limited data are available on micafungin breakthrough fungemia (MBF), fungemia that develops on administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records of patients with hematological disorders who developed MBF between January 2008 and June 2015. A total of 39 patients with MBF were identified, and
Candida
(30 strains) and non-
Candida
(9 strains) fungal species were recognized as causative strains. Among 35 stored strains,
Candida parapsilosis
(14 strains),
Trichosporon asahii
(7 strains),
Candida glabrata
(5 strains), and other fungal species (9 strains) were identified by sequencing. Neutropenia was identified as an independent predictor of non-
Candida
fungemia (
P
= 0.023).
T. asahii
was the most common causative strain (7/19) during neutropenia. The 14-day crude mortality rate of patients treated with early micafungin change (EMC) to other antifungal agents was lower than that of the patients not treated with EMC (14% versus 43%,
P
= 0.044). Most of the stored causative
Candida
strains were susceptible (80%) or showed wild-type susceptibility (72%) to micafungin. The MICs of voriconazole for
T. asahii
were low (range, 0.015 to 0.12 μg/ml), whereas the MICs of amphotericin B for
T. asahii
were high (range, 2 to 4 μg/ml). MBF caused by non-
Candida
fungus should be considered, especially in patients with neutropenia. EMC could improve early mortality. Based on epidemiology and drug susceptibility profiling, empirical voriconazole-containing therapy might be suitable for treating MBF during neutropenia to cover for
T. asahii
.
Monitoring Viable Cells of the Biological Control Agent Lactobacillus plantarum PM411 in Aerial Plant Surfaces by Means of a Strain-Specific Viability Quantitative PCR Method
Authors: Daranas Núria , Bonaterra Anna , Francés Jesús , Cabrefiga Jordi , Montesinos Emilio , Badosa Esther 
Published: March 2018

ABSTRACT

A viability quantitative PCR (v-qPCR) assay was developed for the unambiguous detection and quantification of
Lactobacillus plantarum
PM411 viable cells in aerial plant surfaces. A 972-bp region of a PM411 predicted prophage with mosaic architecture enabled the identification of a PM411 strain-specific molecular marker. Three primer sets with different amplicon lengths (92, 188, and 317 bp) and one TaqMan probe were designed. All the qPCR assays showed good linearity over a 4-log range and good efficiencies but differed in sensitivity. The nucleic acid-binding dye PEMAX was used to selectively detect and enumerate viable bacteria by v-qPCR. The primer set amplifying a 188-bp DNA fragment was selected as the most suitable for v-qPCR. The performance of the method was assessed on apple blossoms, pear, strawberry, and kiwifruit leaves in potted plants under controlled environmental conditions, as well as pear and apple blossoms under field conditions, by comparing v-qPCR population estimations to those obtained by qPCR and specific plate counting on de Man-Rogosa-Sharpe (MRS)-rifampin. The population estimation did not differ significantly between methods when conditions were conducive to bacterial survival. However, under stressful conditions, differences between methods were observed due to cell death or viable-but-nonculturable state induction. While qPCR overestimated the population level, plate counting underestimated this value in comparison to v-qPCR. PM411 attained stable population levels of viable cells on the flower environment under high relative humidity. However, the unfavorable conditions on the leaf surface and the relatively dryness in the field caused an important decrease in the viable population.

IMPORTANCE
The v-qPCR method in combination with plate counting and qPCR is a powerful tool for studies of colonization and survival under field conditions, to improve formulations and delivery strategies of PM411, and to optimize the dose and timing of spray schedules. It is expected that PEMAX v-qPCR could also be developed for monitoring other strains on plant surfaces not only as biological control agents but also beneficial bacteria useful in the sustainable management of crop production.
Complete Genomic Characterization of Korean Porcine Epidemic Diarrhea Virus Strain KUPE21
Authors: Park Jun Woo , Yoo Sung J. , Kwon Taeyong , Moon Youngkwang , Lyoo Young S. 
Published: March 2018

ABSTRACT
Nationwide porcine epidemic diarrhea virus (PEDV) outbreaks occurred in late 2013 in the Republic of Korea, resulting in an expansion of genomic data for Korean PEDVs. However, the data available for Korean PEDVs before 2013 are insufficient. Therefore, we sequenced and analyzed the complete genome of a Korean PEDV strain, KUPE21, which was isolated in the early 2000s.
Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok
Authors: Sapp Amanda , Huguet-Tapia José C. , Sánchez-Lamas Maximiliano , Antelo Giuliano T. , Primo Emiliano D. , Rinaldi Jimena , Klinke Sebastián , Goldbaum Fernando A. , Bonomi Hernán R. , Christner Brent C. , Otero Lisandro H. 
Published: March 2018

ABSTRACT

Here, we report the draft genome sequence of
Methylobacterium
sp. strain V23, a bacterium isolated from accretion ice of the subglacial Lake Vostok (3,592 meters below the surface). This genome makes possible the study of ancient and psychrophilic genes and proteins from a subglacial environment isolated from the surface for at least 15 million years.
Complete Genome Sequence of the Symbiotic Strain Bradyrhizobium icense LMTR 13
T
, Isolated from Lima Bean (Phaseolus lunatus) in Peru
Authors: Ormeño-Orrillo Ernesto , Rogel Marco A. , Zúñiga-Dávila Doris , Martínez-Romero Esperanza 
Published: March 2018

ABSTRACT

The complete genome sequence of
Bradyrhizobium icense
LMTR 13
T
, a root nodule bacterium isolated from the legume
Phaseolus lunatus
, is reported here. The genome consists of a circular 8,322,773-bp chromosome which codes for a large and novel symbiotic island as well as genes putatively involved in soil and root colonization.
Prevalence and treatment of spontaneous intracranial artery dissections in patients with acute stroke due to intracranial large vessel occlusion
Authors: Labeyrie Marc-Antoine , Civelli Vittorio , Reiner Peggy , Aymard Armand , Saint-Maurice Jean-Pierre , Zetchi Akli , Houdart Emmanuel 
Published: March 2018

ObjectiveTo identify the prevalence and therapeutic consequences of spontaneous intracranial artery dissection (IAD) at the acute phase of ischemic stroke.MethodsWe reviewed clinical and imaging data of consecutive patients attending our center for mechanical thrombectomy (MT) between January 2012 and November 2017. IAD was defined according to published criteria and our own angiographic criteria (no clot following MT, and normalization of the vessel caliber after stenting).ResultsIAD was retrospectively diagnosed in 13/391 (3%) patients (inter-rater agreement κ=0.885, P<0.001). It was an extending of extracranial dissection in 7/13 (54%) patients. A total of 21 recanalization approaches (with or without IV tissue plasminogen activator) were analyzed in 13 patients. A medical approach was used in 7/21 (33%), MT in 7/21 (33%) (stent retriever=6, thromboaspiration=1), and permanent stenting in 7/21 (33%). A rescue recanalization was necessary after 8/14 (57%) approaches without stenting. Stenting was associated with a best rate of recanalization (P=0.001) and with a trend towards a lower rate of ischemic recurrence (P=0.057). Stenting of a circulating false lumen failed to recanalize the artery in two patients. At the last follow-up, no patient had developed a subarachnoid hemorrhage due to the dissection. The outcome at 3 months was favorable in 8/13 (62%) patients. One patient died at 3 weeks owing to a severe cerebellar infarction.ConclusionIAD is a rare diagnosis that should be systematically considered in patients with intracranial large vessel occlusion, especially in patients with extracranial artery dissection and when MT does not retrieve any clot. Stenting of IAD as first-line approach should be assessed in further studies.
Giant mass-transport deposits in the southern Scotia Sea (Antarctica)
Authors: Somoza Luis , Medialdea Teresa , González Francisco J. 
Published: March 2018

Abstract

On the basis of 2D multichannel and very-high-resolution seismic data and swath bathymetry, we report a sequence of giant mass-transport deposits (MTDs) in the Scan Basin (southern Scotia Sea, Antarctica). MTDs with a maximum thickness of
c.
300 m extend up to 50 km from the Discovery and Bruce banks towards the Scan Basin. The headwall area consists of multiple U-shaped scars intercalated between volcanic edifices, up to 250 m high and 7 km wide, extending
c.
14 km downslope from 1750 to 2900 m water depth. Seismic sections show that these giant MTDs are triggered by the intersection between diagenetic fronts related to silica transformation and vertical fluid-flow pipes linked to magmatic sills emplaced within the sedimentary sequence of the Scan Basin. This work supports that the diagenetic alteration of siliceous sediments is a possible cause of slope instability along world continental margins where bottom-simulating reflectors related to silica diagenesis are present at a regional scale.
Quantitative characterization of subaqueous landslides in Lake Zurich (Switzerland) based on a high-resolution bathymetric dataset
Authors: Strupler M. , Anselmetti F. S. , Hilbe M. , Strasser M. 
Published: March 2018

Abstract

New high-resolution surveying techniques allow subaqueous geomorphology to be investigated in great detail. Such analyses are important as the morphologies are often indicative of past processes, including mass movements. For peri-alpine Lake Zurich, many mass-wasting events have occurred in the past millennia. While the ages of these events are known from past studies on the respective deposits in the lake basin, the surface expressions and distribution of the respective features on the slopes have not been extensively described. Here we quantitatively characterize the morphologic features on the entire lake floor. A total of 50 subaqueous landslides are morphologically identified in a high-resolution digital bathymetric model (DBM), mapped and characterized using a geographic information system (GIS). Many slides show relatively small erosion areas (<0.05 km
2
) and are located in shallow water (<10 m water depth). The roughness of the individual landslide-translation areas is quantified using the standard deviation of a measure called bathymetric position index (BPI) and related to the slides ages. The DBM allows the detection of traces of mass-movements dating back to
c.
5000 cal years BP. Our results demonstrate that morphometric analyses on a high-resolution DBM can contribute to a better understanding of sublacustrine mass movements.
Combining
in situ
monitoring using seabed instruments and numerical modelling to assess the transient stability of underwater slopes
Authors: Urlaub Morelia , Villinger Heinrich 
Published: March 2018

Abstract

The stability of submarine slopes is often characterized using campaign-based geophysical and geotechnical measurements in combination with numerical modelling. However, such one-off measurements do not reflect transient changes in slope stability.
In situ
monitoring of physical parameters critical for slope stability over periods of months to years can provide crucial information on slope stability and can also be used in an early-warning system for submarine landslides and the possibly resulting tsunamis. We review existing techniques that are capable of monitoring seafloor deformation over long periods of time. Based on numerical models we can identify the magnitude of parameters related to landslide-induced seafloor deformation. Simulations of three different failure scenarios up to the point of failure show that the development of the stress state of a slope and hence stability over time can be captured by measurements of tilt, pressure and strain at the seafloor. We also find that different failure mechanisms induce different deformation signals at the seafloor, in particular tilt. Hence, with a site- and target-specific survey design (or a large pool of instruments), seafloor deformation measurements in combination with numerical modelling can be used to determine the temporal evolution of slope stability as well as to identify underlying failure mechanisms.
Tsunami modelling of the 7250 cal years BP Betsiamites submarine landslide
Authors: Turmel Dominique , Locat Jacques , Leblanc Jonathan , Cauchon-Voyer Geneviève 
Published: March 2018

Abstract

On the north shore of the St Lawrence Estuary (Québec, Canada), near the Betsiamites river delta, a large sub-aerial submarine landslide complex was mapped using multi-beam bathymetry and light detection and ranging (LiDAR) data. Previous analysis of this landslide complex revealed that, since 7250 cal years BP, at least four different landsliding events occurred to form the present morphology, in which over 2 km
3
of material have been mobilized. The 7.25 cal ka BP landslide is of particular interest here: this landslide is entirely submarine and mobilized about 1.3 km
3
of material, deposited over an area of 54 km
2
, which make this landslide the largest identified on the St Lawrence estuary seafloor. This landslide showed a runout distance of about 15 km. Landslide-generated tsunamis may be triggered by such a landslide, where a large volume of material is mobilized in a short time. Kinematic analysis of this landslide was previously performed, and here we use these analyses in order to perform tsunami wave generation and propagation modelling. It is shown in this analysis that, even if the mobilized volume is very high and there is a long runout, the tsunami generated is small with tsunami wave amplitudes of <1.5 m, except in the vicinity of the landslide. The highest tide elevation in this part of the St Lawrence Estuary is about 5.5 m, so the impact of such a tsunami wave may be limited.
Postoperative seizure outcome-guided machine learning for interictal electrocorticography in neocortical epilepsy
Authors: Park Seong-Cheol , Chung Chun Kee 
Published: March 2018

The objective of this study was to introduce a new machine learning guided by outcome of resective epilepsy surgery defined as the presence/absence of seizures to improve data mining for interictal pathological activities in neocortical epilepsy. Electrocorticographies for 39 patients with medically intractable neocortical epilepsy were analyzed. We separately analyzed 38 frequencies from 0.9 to 800 Hz including both high-frequency activities and low-frequency activities to select bands related to seizure outcome. An automatic detector using amplitude-duration-number thresholds was used. Interictal electrocorticography data sets of 8 min for each patient were selected. In the first training data set of 20 patients, the automatic detector was optimized to best differentiate the seizure-free group from not-seizure-free-group based on ranks of resection percentages of activities detected using a genetic algorithm. The optimization was validated in a different data set of 19 patients. There were 16 (41%) seizure-free patients. The mean follow-up duration was 21 ± 11 mo (range, 13–44 mo). After validation, frequencies significantly related to seizure outcome were 5.8, 8.4–25, 30, 36, 52, and 75 among low-frequency activities and 108 and 800 Hz among high-frequency activities. Resection for 5.8, 8.4–25, 108, and 800 Hz activities consistently improved seizure outcome. Resection effects of 17–36, 52, and 75 Hz activities on seizure outcome were variable according to thresholds. We developed and validated an automated detector for monitoring interictal pathological and inhibitory/physiological activities in neocortical epilepsy using a data-driven approach through outcome-guided machine learning.NEW & NOTEWORTHY Outcome-guided machine learning based on seizure outcome was used to improve detections for interictal electrocorticographic low- and high-frequency activities. This method resulted in better separation of seizure outcome groups than others reported in the literature. The automatic detector can be trained without human intervention and no prior information. It is based only on objective seizure outcome data without relying on an expert’s manual annotations. Using the method, we could find and characterize pathological and inhibitory activities.