bluuebunny/crossref_metadata_2025_split huggingface dataset:
L-norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer’s disease
Authors: Polis Baruh , Srikanth Kolluru D , Elliott Evan , Gil-Henn Hava , Samson Abraham O. 
Published: June 2018

AbstractThe urea cycle plays a role in the pathogenesis of Alzheimer’s disease (AD). Arginase-I accumulation at sites of amyloid-beta deposition is associated with L-arginine deprivation and neurodegeneration. Moreover, a positive interaction between the arginase-II and mTOR-S6K1 pathways promote inflammation and oxidative stress. In this study, we treated 3xTg-AD mice exhibiting increased ribosomal protein S6 kinase beta-1 (S6K1) activity and wild-type (WT) mice with L-norvaline. The substance combines unique properties of arginase and S6K1 inhibition. The treated 3xTg-AD mice demonstrated significantly improved acquisition of spatial memory, associated with a substantial reduction of microgliosis and shift from activated to resting phenotype. Moreover, an increase of dendritic spines density and escalation of the expression rates of neuroplasticity related proteins were followed by a decline in the levels of amyloid-beta toxic oligomeric and fibrillar species in the hippocampus. Our findings associate local amyloid-beta-driven and immune-mediated response with altered L-arginine metabolism and suggest that arginase and S6K1 inhibition by L-norvaline can delay progression of AD.
Excitatory and inhibitory subnetworks are equally selective during decision-making and emerge simultaneously during learning
Authors: Najafi Farzaneh , Elsayed Gamaleldin F , Cao Robin , Pnevmatikakis Eftychios , Latham Peter E. , Cunningham John P , Churchland Anne K 
Published: June 2018

SummaryInhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in primary visual cortex: inhibitory neurons are broadly tuned in vivo, and show non-specific connectivity in slice. Selectivity of excitatory and inhibitory neurons within decision circuits, and hence the validity of decision-making models, is unknown. We simultaneously measured excitatory and inhibitory neurons in posterior parietal cortex of mice judging multisensory stimuli. Surprisingly, excitatory and inhibitory neurons were equally selective for the animal’s choice, both at the single cell and population level. Further, both cell types exhibited similar changes in selectivity and temporal dynamics during learning, paralleling behavioral improvements. These observations, combined with modeling, argue against circuit architectures assuming non-selective inhibitory neurons. Instead, they argue for selective subnetworks of inhibitory and excitatory neurons that are shaped by experience to support expert decision-making.
The foliar endophytePhialocephala scopiformisDAOMC 229536 secretes enzymes supporting growth on wood as sole carbon source
Authors: Bhatnagar Jennifer M. , Sabat Grzegorz , Cullen Daniel 
Published: June 2018

AbstractThe conifer needle endophyte,Phialocephala scopiformis, was cultivated in media containing groundPinus contortawood as sole carbon source. After five and seven days growth, concentrated extracellular fluids were subjected to LC-MS/MS analyses. A total of 590 proteins were identified of which 99 were assigned to glycoside hydrolase families within the Carbohydrate Active Enzyme (CAzyme) system. Multiple isozymes of exo-and endo-acting cellulases were among the most abundant proteins, and oxidative degradation of cellulose was supported by the presence of lytic polysaccharide monooxygenases, glucooligosaccharide oxidase and cellobiose dehydrogenase. Oxidoreductases were also plentiful and included GMC oxidoreductases, alcohol dehydrogenases, laccases, copper radical oxidases, tyrosinases and catalase. The expression and diversity of extracellular oxidoreductases indicates a capacity to metabolize alcohols and aromatic compounds.
Electrocorticographic responses to time-compressed speech vary across the cortical auditory hierarchy
Authors: Davidesco Ido , Thesen Thomas , Honey Christopher J , Melloni Lucia , Doyle Werner , Devinsky Orrin , Ghitza Oded , Schroeder Charles , Poeppel David , Hasson Uri 
Published: June 2018

AbstractHuman listeners understand spoken language across a variety of rates, but when speech is presented three times or more faster than its usual rate, it becomes unintelligible. How the brain achieves such tolerance and why speech becomes unintelligible above certain rates is still unclear. We addressed these questions using electrocorticography (ECoG) recordings in 7 epileptic patients (two female). Patients rated the intelligibility of sentences presented at the original rate (100%), speeded rates (33% or 66% of the original sentence duration) and a slowed rate (150%). We then examined which parameters of the neural response covary with the transition from intelligible to unintelligible speech. Specifically, we asked whether neural responses: 1) track the acoustic envelope of the incoming speech; 2) “scale” with speech rate, i.e. whether neural responses elicited by slowed and speeded sentences can be linearly scaled to match the responses to the original sentence. Behaviorally, intelligibility was at ceiling for speech rates of 66% and above, but dropped significantly for the 33% rate. At the neural level, Superior Temporal Gyrus regions (STG) in close proximity to A1 (‘low-level’) tracked the acoustic envelope and linearly scaled with the input across all speech rates, irrespective of intelligibility. In contrast, secondary auditory areas in the STG as well as the inferior frontal gyrus and angular gyrus (‘high-level’) tracked the acoustic envelope and linearly scaled with input only for intelligible speech. These results help reconcile seemingly contradictory previous findings and provide better understanding of how information processing unfolds along the cortical auditory hierarchy.
A new calcium-activated dynein adaptor protein, CRACR2a, regulates clathrin-independent endocytic traffic in T cells
Authors: Wang Yuxiao , Huynh Walter , Skokan Taylor D. , Vale Ronald D. 
Published: June 2018

AbstractCytoplasmic dynein is a microtubule minus-end-directed motor that transports numerous intracellular cargoes. Mammalian dynein transport is initiated by coiled-coil adaptor proteins that 1) join dynein and its co-factor dynactin into a complex capable of processive motility, and 2) interact with a cargo-bound receptor, which is frequently a Rab GTPase on an organelle. Here, we report two novel dynein adaptors, CRACR2a and Rab45, which have a coiled-coil adaptor domain, a pair of EF hands, and a Rab GTPase domain fused into a single polypeptide. We find that CRACR2a-mediated dynein-dynactin motility is activated by calcium in vitro and in cells. In activated T cells, CRACR2a localizes to clathrin-independent endosomes that require microtubule-based transport to detach from the actin cortex and travel towards the microtubule organizing center. Together these results represent the first known examples of Rab GTPases that directly act as dynein adaptors and implicate CRACR2a-dynein in regulation of endocytic trafficking in T cells.
Frequency changing technique for efficient fast start-up RF energy harvesting
Authors: Shieh Sajjad , Kamarei Mahmoud 
Published: June 2018

Purpose
The purpose of the paper is to present a frequency-changing technique to realize a fast start-up radio frequency (RF) energy harvester.

Design/methodology/Approach
First, a simple analysis of the input impedance of the rectifier circuit is presented, and based on the analysis, it is shown how the input impedance of the rectifier is changed during the rectifier charging. Then, the frequency-changing technique is presented in which the variation of the rectifier input reactance (capacitance) is partly compensated by changing the frequency of the transmitted RF signal. A harvester consisting of a four-stage rectifier and a simple series matching inductor, implemented based on Schottky diode, is employed to verify the technique.

Findings
With the input available power of −12 dBm, the simulated and the measured results prove that the proposed frequency-changing method compared to the typical fixed-frequency method shows more than 30 per cent decrease in the transient time to reach 0.5 V output voltage, while the final harvested output voltage is unchanged.

Originality/Value
A frequency-changing technique is presented.
Inclusive workplace and organizational citizenship behavior
Authors: Panicker Aneesya , Agrawal Rakesh Kumar , Khandelwal Utkal 
Published: June 2018

PurposeThe purpose of this paper is to examine the relationship between employees’ perception of an inclusive workplace, namely, inclusive practices, inclusive climate and inclusive leadership and organizational citizenship behavior (OCB). It also attempts to examine the difference in perception toward the inclusive workplace along the three major dimensions of diversity, namely, gender, category they belong to and their religious orientation.Design/methodology/approachNon-probability sampling technique is employed to collect primary data through a self-administered questionnaire from 492 academicians of a higher education institution situated in western Uttar Pradesh of India. The data set was analyzed using statistical tools like descriptive statistics (z-test and ANOVA), and multiple regression analysis.FindingsResults of the multiple regression analysis reflected direct and significant relationship between inclusive workplace and OCB. It has been observed that organizations with a conducive climate of inclusion, a well formulated inclusive practices and strong leaders’ commitment will result into high level of OCB which is apparent among employees working in a higher education institution western Uttar Pradesh. The results ofz-test reflected that male and female employees have similar perception toward inclusive climate. However, there is a significant difference in perception toward inclusive practices and inclusive leadership on OCB. On the other hand, results of ANOVA reflected that with respect to religious orientation there is no significant difference among perceptions toward inclusive workplace. However in case of category employees have similar perception toward inclusive climate in contrast with inclusive practices and inclusive leadership.Research limitations/implicationsThe present study established the concept of inclusive workplace, entirely on the basis of individual viewpoint. While to examine the cause and effect relationship of an inclusive workplace on OCB, it is recommended to incorporate some moderating or intervening variables.Practical implicationsThis study provides guidelines for academic institutions to understand and foster an inclusive workplace that will encourage the academicians to exhibit OCB.Originality/valueVery little research had examined the relationship between inclusive workplace and OCB. This research will add value to the existing literature on inclusive workplace and its probable impact on organizations and individuals by examining this relationship with respect to gender, category and religious orientation of employees working in higher educational institution of India.
Institutional racism in the film industry: a multilevel perspective
Authors: Hennekam Sophie , Syed Jawad 
Published: June 2018

PurposeWhile the notion of institutional racism typically focuses on racial discrimination in institutions such as governmental organisations, academic institutions and courts of law, there is a need to complement this organisational (meso) focus with the investigation of relevant factors at the societal (macro) and individual (micro) levels. The purpose of this paper is to examine the multilevel factors influencing institutional racism in the film industry.Design/methodology/approachDrawing on 16 in-depth interviews with individuals working in the film industry, this paper develops a conceptual perspective of multilevel racism.FindingsThe findings highlight how power structures, network-based recruitment practices, as well as formal and informal learning lead to and sustain racism in the film industry. However, agency on an individual level is observed as a way to break those patterns.Originality/valueThe findings highlight how individual agency pushes for more equality and diversity in the film industry, despite the barriers encountered on macro- and meso-levels. In addition, the important role of informal and formal learning through observation is stressed as a means to sustain the discriminatory practices in this industry.
Unsteady flow and heat transfer over a permeable stretching/shrinking sheet with generalized slip velocity
Authors: Hafidzuddin Mohd Ezad Hafidz , Nazar Roslinda , M. Arifin Norihan , Pop Ioan 
Published: June 2018

Purpose
This study aims to investigate the unsteady two-dimensional viscous flow and heat transfer over an unsteady permeable stretching/shrinking sheet (surface) with generalized slip velocity condition.

Design/methodology/approach
Similarity transformation is used to reduce the system of partial differential equations into a system of nonlinear ordinary differential equations. The resulting equations are then solved numerically using “bvp4c” function in MATLAB software.

Findings
Dual solutions are found for a certain range of the unsteady, suction and stretching/shrinking parameters. Stability analysis is performed, and it is revealed that the first (upper branch) solution is stable and physically realizable, whereas the second (lower branch) solution is unstable.

Practical implications
The results obtained can be used to explain the characteristics and applications of the generalized slip in boundary layer flow. Such condition is applied for particulate fluids such as foams, emulsions, polymer solutions and suspensions. Furthermore, the phenomenon of stretching/shrinking sheet can be found on the manufacturing of polymer sheets, rising and shrinking balloon or moving and shrinking polymer film.

Originality/value
The present numerical results are original and new for the study of unsteady flow and heat transfer over a permeable stretching/shrinking sheet with generalized slip velocity.
SOX 404 and debt contracting value of accounting information
Authors: Li Shihong 
Published: June 2018

Purpose
This paper aims to investigate whether the Section 404 of Sarbanes–Oxley Act (SOX 404) changed the way banks use accounting information to price corporate loans.

Design/methodology/approach
The study uses a sample of 1,173 US-listed firms that issued syndicated loans both before and after their compliance with SOX 404 to analyze the changes in loan spread’s sensitivity to some key accounting metrics such as ROA, interest coverage, leverage and net worth.

Findings
The study finds that the interest spread’s sensitivity to key accounting metrics, most noticeably for ROA, declined following the borrower’s compliance with the requirements of SOX 404. The decline was not explainable by borrowers that disclosed internal control weaknesses but concentrated among borrowers suspected of real earnings management (REM).

Originality/value
By examining the effects of SOX 404 on banks’ pricing process, this study augments the literature on SOX’s economic consequences. The findings suggest that lenders perceive little new information from SOX 404 disclosures of internal control deficiencies and are cautious about the accounting information provided by REM borrowers. It also extends the research on the use of accounting information in debt contracting. By examining loan interest’s sensitivity to accounting metrics, it broadens the concept of debt contracting value of accounting information to include accounting’s usefulness for assessing credit risk at loan inception.
Investigation of the acoustic properties of needle punched nonwoven produced of blend with sustainable fibers
Authors: Islam Shariful , Mominul Alam Shaikh Md. 
Published: June 2018

Purpose
The purpose of this paper is to investigate the acoustic properties of needle-punched nonwovens produced of bamboo, banana and hemp fibers blended with polyester (PET) and polypropylene (PP) as they are supportive enough to minimize sound transmission inside the automobiles.

Design/methodology/approach
Textile materials like bamboo, banana and hemp blended with PET and PP in the ratio of 35:35:30 were applied to make the web. The needle-punching technique was applied to each web for three times to form a full nonwoven textile composite. The concept of PET/PP blend with natural fibers was to enhance the consistency and thermoform propensity of the composites. When nonwoven textile composites were placed in between a sound source and a receiver, they absorbed annoying sound by dissolving sound wave energy. Sound absorption coefficient was measured by the impedance tube method as per ASTM C384 Standard. Bamboo/PET/PP composite showed the highest absorption coefficient in most of the frequencies.

Findings
Physical and comfort properties were tested for the composites and it was noticed that bamboo/PET/PP composites with its compressed structure showed a better stiffness value, lesser thermal conductivity, lesser air permeability, better absorption coefficient and highest sound transmission loss compared to other two composites. At 840 Hz, the absorption coefficient of bamboo/PET/PP remained in satisfactory level but it was inferior by 20 percent in banana/PET/PP. Conversely at more frequencies like 1,680 Hz, there was a decrease from the target level in all the nonwovens composites, which could be enhanced by raising the thickness of the nonwovens, and all these properties of bamboo/PET/PP were considered appropriate for controlling noise inside the vehicles.

Practical implications
This research will provide facilities to decrease noise inside the vehicles. It will improve the apparent value of the automobiles to the traveler and also provide a sensible goodwill to the manufacturer.

Originality/value
This research will open several ways for the development of different nonwoven composites, particularly for the sound absorption and will open possible ways for the scholars to further study in this field.
Relationship between maternal, household, and socio-economic characteristics and household food security in Aceh, Indonesia
Authors: Srinita Srinita 
Published: June 2018

Purpose
The purpose of this paper is to investigate the relationship between maternal, household and socio-economic characteristics and household food security in Aceh Province, Indonesia.

Design/methodology/approach
The data used are cross-section, secondary data from the Economic Census of Indonesia in 2016 (BPS, 2016) from 23 districts/cities. The central message of the present empirical analysis is that relatively simple indicators perform well in locating food security.

Findings
The analysis proves that mother’s age has a significant effect on average calorie intake at the household level. This may be due to the fact that mother’s age plays an important role in the provision of proper food to her family. Higher-aged mothers can understand better about the food quality and requirement for the family as compared to low-aged mother. Environmental factors like access to safe water and better sanitation facilities within housing premises indirectly enhance the absorptive capacity of available food intake. Thus, environmental factors could play an important role in food security through calorie intake, irrespective of economic status of the household. This analysis further strengthens the earlier findings that higher food intake availability alone may not lead to improved health outcome, unless measures are taken to improve access to safe water and sanitation. The contribution of dependency ratio in per capita calorie intake also appeared to be significant in this study. This shows that high dependency ratio reduces the per capita calorie intake due to a larger share in food items among households.

Originality/value
No previous study has comprehensively studied the relationship between maternal, household, and socio-economic characteristics and household food security, especially in Aceh, Indonesia.
Moderating effect of organizational citizenship behavior on the effect of organizational commitment, transformational leadership and work motivation on employee performance
Authors: Rita Marcy , Randa Payangan Otto , Rante Yohanes , Tuhumena Ruben , Erari Anita 
Published: June 2018

Purpose
This study aims to examine the relationship between transformational leadership, organizational commitment, motivation, organizational citizenship behavior (OCB) and employee performance.

Design/methodology/approach
This research is located in the province of Papua, and more specifically at the District Secretariat Papua Province. The study was conducted in the months from April to June 2016. This study tested the effect of transformational leadership, organizational commitment, work motivation, OCB and performance Officer Regional Secretariat Papua Province, then the variable research is transformational leadership, organizational commitment, work motivation, OCB and performance officer. Structural equation modeling (SEM) calculation tool is commonly used is the program analysis of moment structures.

Findings
The results of studies show that moderating OCB does not significantly affect the relationship between organizational commitment, transformational leadership, work motivation and the performance of employees at the District Secretariat in Papua Province.

Originality/value
Originality of this paper is on the comprehensive study that combines the variables of transformational leadership, organizational commitment, work motivation, OCB and performance into a complete model of study. Originality for this paper shows the moderation effect of OCB on the effect of organizational commitment, transformational leadership and work motivation on employee performance. This research is located in the Province of Papua, and more specifically at the District Secretariat Papua Province.
The effect of auditor quality to professional skepticsm and its relationship to audit quality
Authors: Kusumawati Andi , Syamsuddin Syamsuddin 
Published: June 2018

Purpose
The purpose of this paper is to investigate the relationships between auditor quality to professional skepticism and between auditor quality and professional skepticism to audit quality.

Design/methodology/approach
The analysis method to test the causal effect of auditor quality to profesional skepticism and audit quality. The respondent in this research is the auditor in the Audit Board of the Republic of Indonesia in South Sulawesi province using questionnaire. The analysis tool used in this research is partial least square.

Findings
The auditor quality has direct effect on the professional skepticism. Professional skepticism has direct effect on the audit quality. The auditor quality has no direct effect on audit quality, but auditor quality has indirect effect on audit quality with mediation of professional skepticism.

Originality/value
This paper shows a research was conducted about professional skepticism public sector in governmental sector for producing the audit quality, especially in South Sulawesi province in Indonesia. This research retests the research result from Aranya and Amernic (1981); Carcello et al. (1992); Behn et al. (1997); Copley (1998); Brown and Raghunandan (1995); Beasley et al. (2001); Chiu (2003); Suraida (2005); Lewinsohn et al. (1997); Novianti (2008); Varelius (2009). The researcher uses model combination (design) method of sequential explanatory based on evidentiary sequence from Creswell 2009, quantitative research (by instrument using questionnaire).