bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Authors: Karnik Varun , Colombo Sebastiano Maria , Rickards Leah , Heinsar Silver , See Hoe Louise E. , Wildi Karin , Passmore Margaret R. , Bouquet Mahe , Sato Kei , Ainola Carmen , Bartnikowski Nicole , Wilson Emily S. , Hyslop Kieran , Skeggs Kris , Obonyo Nchafatso G. , McDonald Charles , Livingstone Samantha , Abbate Gabriella , Haymet Andrew , Jung Jae-Seung , Sato Noriko , James Lynnette , Lloyd Benjamin , White Nicole , Palmieri Chiara , Buckland Mark , Suen Jacky Y. , McGiffin David C. , Fraser John F. , Li Bassi Gianluigi 
Published: November 2024

AbstractOpen-lung ventilation during cardiopulmonary bypass (CPB) in patients undergoing heart transplantation (HTx) is a potential strategy to mitigate postoperative acute respiratory distress syndrome (ARDS). We utilized an ovine HTx model to investigate whether open-lung ventilation during CPB reduces postoperative lung damage and complications. Eighteen sheep from an ovine HTx model were included, with ventilatory interventions randomly assigned during CPB: the OPENVENT group received low tidal volume (VT) of 3 mL/kg and positive end-expiratory pressure (PEEP) of 8 cm H20, while no ventilation was provided in the NOVENT group as per standard of care. The recipient sheep were monitored for 6 h post-surgery. The primary outcome was histological lung damage, scored at the end of the study. Secondary outcomes included pulmonary shunt, driving pressure, hemodynamics and inflammatory lung infiltration. All animals completed the study. The OPENVENT group showed significantly lower histological lung damage versus the NOVENT group (0.22 vs 0.27, p = 0.042) and lower pulmonary shunt (19.2 vs 32.1%, p = 0.001). In addition, the OPENVENT group exhibited a reduced driving pressure (9.6 cm H2O vs. 12.8 cm H2O, p = 0.039), lower neutrophil (5.25% vs 7.97%, p ≤ 0.001) and macrophage infiltrations (11.1% vs 19.6%, p < 0.001). No significant differences were observed in hemodynamic parameters. In an ovine model of HTx, open-lung ventilation during CPB significantly reduced lung histological injury and inflammatory infiltration. This highlights the value of an open-lung approach during CPB and emphasizes the need for further clinical evidence to decrease risks of lung injury in HTx patients.
Simplified technique in total pancreatectomy with islet cell autotransplantation after Frey’s procedure: a case report
Authors: Oikawa Ryo , Takemura Nobuyuki , Shimoda Masayuki , Nakamura Mai , Mihara Fuminori , Inagaki Fuyuki , Kokudo Norihiro 
Published: November 2024

Abstract
Background
The selection of the surgical approach for chronic pancreatitis (CP) is determined by various factors including inflammatory location, presence of pancreatic duct dilatation, or possibility of cancer. Total pancreatectomy (TP), with or without islet cell autotransplantation, is considered for patients with refractory CP after the failure of other surgical treatments. Considering the increasing incidence of CP requiring surgical treatment, the number of cases in which TP is performed after previous surgical treatment is expected to increase.

Case presentation
We reported a case of TPIAT in a patient with alcoholic CP who had previously undergone Frey’s procedure. During the operation, the sufficient length of the elevated jejunal loop for pancreaticojejunostomy in Frey’s procedure allowed it to be used directly for biliary jejunostomy during TP. In addition, jejunojejunostomy from the previous operation could be used, and these methods contributed to simplifying the operative procedure. We need open hemostasis on post-operative day (POD) 1and a percutaneous drainage tube replacement for an intraperitoneal abscess on POD 24. The patient was discharged from the hospital on POD 37 with normal serum C-peptide level, which suggests favorable insulin secretion from transplanted islets, and the epigastric pain that suffered her preoperatively resulted in a dramatic improvement.

Conclusions
When performing the Frey’s procedure, the elevated jejunal loop and Y-anastomosis jejunal loop with sufficient length allow them to be used directly for the reconstructions in the possible subsequent TP.
Red, green, and blue model assessment and AQbD approach to HPTLC method for concomitant analysis of metformin, pioglitazone, and teneligliptin
Authors: Prajapati Pintu , Patel Pooja , Naik Dhrumi , Haque Anzarul , Shah Shailesh 
Published: November 2024

Abstract
Background
The CDSCO of India has authorized a combination of metformin hydrochloride, teneligliptin hydrochloride, and pioglitazone hydrochloride for the treatment of insulin-independent diabetes. For the purpose of estimating metformin, teneligliptin, and pioglitazone combinations as well as individual commercial formulations, there are a plethora of publicly accessible chromatographic techniques. More importantly, the development of these chromatographic procedures has included the use of chemical solvents that are dangerous to both animals and the environment.

Objectives
However, to date, there has been no documented chromatographic technique that can concomitantly estimate various commercial formulations of drugs under study employing a uniform chromatographic condition and environmentally friendly solvents. In order to concomitantly estimate drugs under study utilizing unified chromatographic conditions, a green HPTLC method was developed.

Method
The AQbD approach was used to carry out the method development. To determine the most important method parameters and response variables, the analytical risk assessment was conducted using the risk priority number ranking and screening approach. Critical method parameters and response variables were modeled using the response surface modeling approach, which relies on the central composite design. Optimal ranges for the intended method operable design region were determined, and control strategy was framed. The chromatographic separation was carried out on preparative TLC plate precoated with silica gel G-60 F254 using 1.0%W/V ammonium acetate in ethanol: water: triethylamine (6.5:0.4:0.6, V/V) as mobile phase. The detection of the anti-diabetic drugs under study was carried out at 267 nm wavelength.

Results
The linearity of metformin, teneligliptin, and pioglitazone was found to be 5000–25000 ng/band, 200–1000 ng/band, and 150–750 ng/band, respectively. The %RSD for robustness and precision study was found to be less than 2.0%. The %recovery of method was found to be 98–102%. The assay results were shown to be in compliance with respective labeled claims of anti-diabetic medications when the suggested method was used for concurrent analysis of several formulations and combinations of drugs under study.

Conclusion
The suggested technique was evaluated utilizing red–green–blue model scoring tools. The suggested technique was determined to be precise, accurate, rapid, cost-effective, and easy to apply for the estimation of drugs under study.
The Sovereignty of Chance
Authors: Urbinati Nadia 
Published: November 2024

Abstract
In the context of the ongoing Common Knowledge symposium “Antipolitics,” this article responds skeptically to the numerous contributions calling for the supplanting of elections by sortition. While lottocracy is proposed as a solution to the flaws of electoral democracy — notably, corruption and violent partisanship — this response focuses on a single theoretical issue: the logic of chance or randomness, which, according to its proponents, should rid politics of corruption and relieve representation of partisanship so as to ultimately prevent the formation of a ruling class separate from the rest of society. The problem with the solution, according to this essay, is that, however useful in many ways, the lottery system of lawmaking is not democratic.
K-line guided approach selection and outcomes assessment for Cervical Ossification of Posterior Longitudinal Ligament (OPLL): A case series with literature review from Pakistan
Authors: Qadri Haseeb Mehmood , Khan Manal , Ansari Nasruddin , Khizar Ahtesham , Bukhari Syed Ahmad Faizan , Bashir Asif 
Published: November 2024

Objectives: To analyze the efficacy of K-line in surgical planning of approach selection for ossification of posterior longitudinal ligament (OPLL) and outcomes assessment by Nurick grading and Modified Japanese Orthopaedic Association (mJOA) scores.
Methods: This is a retrospective case series study conducted at the Departments of Neurosurgery, Punjab Institute of Neurosciences, Lahore in the months of January and February 2024. Patients with complete records were considered. Google Form was used for data. Nurick grading and Modified Japanese Orthopaedic Association (mJOA) scores were calculated for each patient pre- and post-operatively. K-line assessment was done on computerized tomography (CT). Data analysis was performed using Microsoft excel in terms of frequency and percentages.
Results: This study included ten patients with the mean age at presentation was 48.20 ± 9.37 years. Preoperative Nurick grading in our patients was Grade-V (five patients), Grade-IV (two patients) and Grade-III (three patients) with mean of 4.2 ± 0.91 SD whereas six months follow-up Nurick grading was Grade-V (three patients), Grade-IV (three patients) and Grade-III (four patients) with the mean of 3.90 ± 0.87 SD, which indicates neurological improvement. Types of OPLL present in our patients were segmental (4, 40%), continuous (3, 30%), mixed (2, 20%) and localized/others (1, 10%). There were 2 (20%) K-line (+) and 8 (80%) K-line (-) cases. Anterior approach was used in 2 (20%) cases whereas posterior approach was used for the rest of 8 (80%) cases. Mean preoperative mJOA was 10.30 ± 2.45 and mean postoperative mJOA was12.40 ± 2.01 at 6-month follow up, which indicates improvement in our cases.
Conclusion: K-line is a useful radiological indicator in selecting anterior versus posterior approach for patients with cervical OPLL in terms of Nurick grading and mJOA scores.
List of Abbreviations:
OPLL: Ossified Posterior Longitudinal Ligament, DISH: Diffuse Idiopathic Skeletal Hyperostosis, CT: Computed Tomography, mJOA: Modified Japanese Orthopaedic Association, BMP: Bone Morphogenetic Protein, TGF-b: Transforming Growth Factor Beta, ACCF: Anterior Cervical Corpectomy and Fusion.
doi: https://doi.org/10.12669/pjms.40.12(PINS).11094
How to cite this: Qadri HM, Khan M, Ansari N, Khizar A, Bukhari SFA, Bashir A. K-line guided approach selection and outcomes assessment for Cervical Ossification of Posterior Longitudinal Ligament (OPLL): A case series with literature review from Pakistan. Pak J Med Sci. 2024;40(12):S63-S68. doi: https://doi.org/10.12669/pjms.40.12(PINS).11094
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Not All Lines Are Skipped Equally: An Experimental Investigation of Line-Sitting and Express Lines
Authors: Althenayyan Abdullah , Ülkü Sezer , Yang Luyi , Cui Shiliang 
Published: November 2024

Problem definition: In this paper, we investigate how line-sitting and express lines affect customers’ satisfaction and fairness perception about queues. In line-sitting, customers skip the wait by hiring others to stand in line on their behalf. In express lines, customers skip the wait by purchasing priority. Because both schemes disrupt the first-in-first-out (FIFO) rule, they may be perceived to be unfair and lead to customer dissatisfaction. Methodology/results: In three experiments, we find that customers are more satisfied with the overall queueing experience when they encounter a line-sitter than when they encounter an express-line customer, even when the wait time is held constant. We also find that customers perceive express lines as less fair than line-sitting, which has a significant influence on their satisfaction. A key operational difference between line-sitting and express lines is that line-sitting involves a one-to-one swap between a line-sitter doing a fair share of waiting and their client, whereas express lines insert a new priority customer into the queue without an existing surrogate in the queue. We show that if line-sitting includes an insertion by letting a line-sitter hold a spot for more than one customer, then line-sitting is perceived to be just as unfair and unsatisfying as express lines. Managerial implications: Our results imply that express lines can engender a lower fairness perception, thus harming future business through both more negative word of mouth and a higher customer churn. Therefore, service providers should beware of customer backlash against express lines and yet be more open-minded about line-sitting, provided that one-to-one swaps can be enforced. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0338 .
Design of a three-component movable continuous zoom hybrid system with a double-layer diffractive optical element in a dual-band
Authors: Ma Chengshuang , Li Ying , Wu Siyi , Xue Changxi 
Published: November 2024

To address issues with poor image quality, limited material selection, and hard aberration correction in dual-band infrared (3.7–4.8 and 7.7–9.5 µm) zoom systems, we propose incorporating a high diffraction efficiency double-layer diffractive optical element (DLDOE) into the dual-band zoom system. Based on the three-component movable continuous zoom Gaussian model, a cold dual-band infrared refractive-diffractive hybrid zoom optical system with a DLDOE and 20× zoom ratio is designed. The system features a simple structure with only eight lenses and two types of materials. Image quality was assessed at three focal lengths in both middle-wave infrared (MWIR) and long-wave infrared (LWIR) ranges, and the size of the spot before and after the DLDOE was inserted was compared. The results show that the DLDOE ensures excellent image quality of the zoom system. This zoom system is characterized by a high zoom ratio, excellent image quality, and a simple structure, offering advantages in both military and commercial applications.
Feasibility and acceptability of a systematic offer of HIV rapid testing to Family Planning Centers visitors by non-physician professionals in France
Authors: Penot Pauline , Chateauneuf Julie , Simon Anne , Durand François , Barriere Guillaume , Leroy Pierre , Vignier Nicolas 
Published: November 2024

Background
The Human Immunodeficiency Virus (HIV) epidemic remains active among women in Europe, with significant missed opportunities for HIV testing. Although HIV testing falls within the scope of Family Planning Centers (FPCs), it is often not offered. This pilot study assessed the feasibility and acceptability of systematically offering HIV rapid testing by non-physician professionals, independent of medical appointments, to visitors and accompanying persons in FCPs.

Methods
In September 2020, three FPCs in the Paris region were selected for a 6-month pilot based on high local HIV diagnosis rates among women and the absence of an existing HIV rapid testing offer. A dedicated midwife coordinated a certified training course for non-physician professionals, including group discussions on obstacles and facilitators for offering HIV rapid testing, education on HIV and the use of HIV rapid tests, and the development of procedures, including a standardized HIV questionnaire, to systematically offer HIV rapid testing. We measured participation rates in the study and acceptability of the HIV rapid testing offer. We analyzed visitor characteristics, HIV risk factors and knowledge about HIV.

Results
All non-physician professionals across the three FPCs were trained. HIV rapid testing was systematically offered to 261 incoming visitors and accompanying persons from September 2020 to March 2021: 93% completed the questionnaire, and 91% accepted the HIV rapid testing offer; 63% reported prior HIV risk behaviors. Visitors born in North Africa had the least knowledge about HIV. Twenty-two visitors declined the testing offer, citing recent HIV testing, no perceived lack of risk, feeling unprepared, or fear of the outcome.

Conclusion
The results demonstrate the feasibility and strong acceptability of systematically offering HIV rapid testing by non-physician professionals in large urban FPCs. Extending this approach to include sexually transmitted infections (STIs) screening could be beneficial.
Queer Precarities in and out of Higher Education: Challenging Institutional Structures, Yvette Taylor, Matt Brim and Churnjeet Mahn (eds) (2023)
Authors: Giltner H. K. 
Published: November 2024

Review of: Queer Precarities in and out of Higher Education: Challenging Institutional Structures, Yvette Taylor, Matt Brim and Churnjeet Mahn (eds) (2023)
New York: Bloomsbury Academic, 216 pp.,
ISBN 978-1-35027-365-8, h/bk, $90.00
ISBN 978-1-35027-364-1, p/bk, $29.95
ISBN 978-1-35027-367-2, e-book, $26.96
Entrevista a Ángela Perez
Authors: Molina Córdoba Nicolás 
Published: November 2024

Angela Pérez (AP) - Constructora permanente de propuestas educativas locales que favorecen las actividades de las profesoras y profesores de preescolar y primaria en su quehacer docente, y que facilitan la enseñanza de las ciencias como eje transversal en el desarrollo del currículo de estos niveles. Divulgadora de Astronomía con amplia experiencia en el trabajo con la población menor de edad, juvenil y adulta. Autora de los libros “Lo que hijos y padres deben saber de 2012”, editorial Panamericana, Bogotá Colombia, 2011; “Astronomía a través del arte”, editorial EU-Unawe, Leiden, Holanda, 2012; “La Tierra, el cielo y más allá”, editorial Secretos para Contar. Gestora de estrategias y proyectos de divulgación de la astronomía en espacios como El Planetario de Medellín y otros. Presidente y editora de la Circular de la Red de Astronomía de Colombia (RAC).
Nicolás Molina (NM) – Es Licenciado en Física por la Universidad Pedagógica Nacional de Colombia y Magíster en Astronomía por la Universidad Nacional de Colombia. Se desempeña como coeditor de la revista especializada del Observatorio Astronómico Nacional (OAN), eSPECTRA, y es miembro activo del Grupo de Enseñanza y Aprendizaje de la Física (GEAF) de la Universidad Distrital Francisco José de Caldas, así como del Group of Solar Astrophysics (GoSA) del OAN. En el GoSA, adelanta investigaciones sobre el clima espacial tanto en la Tierra como en el sistema solar. Además, cuenta con experiencia en investigación en enseñanza de la física y la astronomía. Actualmente, trabaja como docente en la Institución Educativa Nuestra Señora de la Candelaria en Ráquira, Boyacá. También es cofundador de Orbitamautas, un semillero dedicado a la difusión, divulgación y enseñanza de la Astronomía.
Surgical Treatment of Brachiocephalic Artery Aneurysm With Impending Rupture and Tracheal Communication
Authors: Kim Soon Jin , Kim Kyung Hwa , Kim Jong Hun , Kim Tae Yun 
Published: November 2024

Abstract
Brachiocephalic artery aneurysm is uncommon but may require surgery because it tends to enlarge, rupture, or cause symptoms related to thrombosis or compression. This case report describes a brachiocephalic artery aneurysm in a 72-year-old man who presented at the hospital with dyspnea and hemoptysis resulting from impending rupture and tracheal communication.
Addendum to On Kuratowski partitions in the Marczewski and Laver structures and Ellentuck topology
Authors: Jureczko Joanna 
Published: November 2024

Abstract
This is an addendum to [R. Frankiewicz, J. Jureczko and B. Weglorz,
On Kuratowski partitions in the Marczewski and Laver structures and Ellentuck topology,
Georgian Math. J. 26 2019, 4, 591–598].
A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients
Authors: Meyyazhagan Praveena , Kanagaraj Thamaraiselvi , Annamalai Nachal 
Published: November 2024

Abstract

Objectives
The pervasiveness of type 2 diabetes mellitus (T2DM) is rapidly increasing worldwide, with physical inactivity being one of the major risk factors. Hand grip strength (HGS) is an important indicator of overall physical functioning and has been associated with various health-related outcomes. The purpose of this study was to investigate the impact of physical activity on the HGS of patients with type 2 diabetes mellitus (T2DM). Furthermore, it scrutinizes the relationship between physical activity and HGS in terms of sex.

Methods
A cross-sectional study including a total of 140 patients with T2DM was performed. Physical activity levels were assessed via the International Physical Activity Questionnaire (IPAQ). HGS was measured via a Camry digital handgrip dynamometer. Statistical analysis was performed via SPSS software, and statistical approaches such as ANOVA, Pearson correlation and t tests were used.

Results
The results of this research will contribute to the detection of the influence of physical activity and its association with HGS. These findings reveal that physical activity has a significant effect on HGS and that there is a positive correlation between physical activity and increased hand grip strength in individuals with T2DM.

Conclusions
The outcomes offer valuable insights into physical activity and muscle strength, which can aid in the early detection of physical disability. The findings of this study will be valuable for healthcare providers and professionals to suggest relevant physical activities for diabetic patients.
Age and sex mark clinical differences in the presentation of pediatric type 1 diabetes mellitus
Authors: Gupta Esha A. , Huang Xiaofan , Velasquez Horacio J. , Golani Khushboo , Siller Alejandro F. , Minard Charles G. , Tosur Mustafa , Redondo Maria J. 
Published: November 2024

Abstract

Objectives
Type 1 diabetes mellitus (T1D) is a heterogeneous condition. We aimed to study the associations between age and sex with clinical characteristics at the onset of pediatric T1D.

Methods
A secondary analysis was conducted on data collected retrospectively from 706 children newly diagnosed with T1D at a large tertiary hospital in southeastern USA. Age (stratified across three cohorts from 0.84 to 18.08 years), sex, and their interaction were compared for associations with clinical characteristics of T1D at presentation by multivariable regression analyses and pairwise comparisons.

Results
Within the participants (mean age 9.71 (SD 4.10), 48.3 % female, 21.0 % Hispanic, 15.3 % non-Hispanic black and 58.7 % non-Hispanic white), children under 6 years had higher glucose (p<0.001), lower hemoglobin A1c (HbA1c) (p<0.001), and lower C-peptide (p<0.001) than the older age groups. Diabetic ketoacidosis (DKA) was more prevalent in the youngest (p=0.005) and the intermediate-aged cohorts (p=0.005), compared to the oldest group. Among the children with DKA, bicarbonate was lower in the youngest (p<0.001) and middle cohorts (p=0.013), compared to the oldest group. Younger age was associated with higher prevalence of insulin autoantibodies (IAA; p<0.001) and IA-2 autoantibodies (IA-2A; p=0.006). Males had higher glucose (p=0.001), but lower HbA1c (p=0.003), lower C-peptide (p<0.001), and lower GAD autoantibody (GADA) prevalence (p=0.001) than females. There was no significant interaction between age and sex.

Conclusions
In children with new onset T1D, younger age and male sex were associated with findings suggestive of more rapid and aggressive T1D preclinical course, including poorer beta-cell function, and distinct islet autoantibody profiles.