bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal fibroscopy as a routine screening procedure of sinonasal adenocarcinoma of woodworkers: French longitudinal case study
Authors: Martin Julie , Vayr Flora , Paris Christophe , Vergez Sébastien , Krief Peggy , Luc Amandine , Corvisier Julie ,   CERBois members, de Gabory Ludovic , Herin Fabrice 
Published: May 2018

AbstractBackgroundThe purpose of this study was to assess the relevancy of flexible nasoendoscopy as a routine screening procedure of sinonasal adenocarcinoma among people occupationally exposed to wood dust.MethodsThis study included woodworkers, occupationally exposed to wood dust. Evaluations were scheduled at the time of inclusion (T0) and after a 2‐year period (T1). A questionnaire was used for standardized data collection. The score was based on anatomic landmarks on each side that are parts of the olfactory clefts: the area of middle turbinate, the anterior part of the olfactory cleft, the top of the choanal arch, the spheno‐ethmoidal recess, the posterior part of the olfactory cleft, and the middle part of the olfactory cleft.ResultsA total of 965 nasoendoscopies (T0+T1) were performed. Olfactory clefts were visualized in 72% of the cases. Nasoendoscopies revealed pathological findings in 33.6% of cases: polyps, thick nasal secretion aspect, mucous edema, retractile scars and synechia, crusts, mucous erythema, and growth. One case of carcinoma was confirmed. Adverse effects (epistaxis, blood mark on the endo‐sheath, sneezing, or rhinorrhea) after the medical procedure occurred in 30% of cases without severe complications.ConclusionFlexible nasoendoscopy offers meaningful efficacy and a promising safety profile, and, therefore, could become the new cornerstone of the routine screening procedure of sinonasal adenocarcinoma among woodworkers.
Racial differences in the prevalence of oncogenic oral human papillomavirus infection types in the United States adult population
Authors: Raymond Samantha , Liu Bian , Taioli Emanuela 
Published: May 2018

AbstractBackgroundThe purpose of this study was to describe the prevalence of oral human papillomavirus (HPV) types according to race and to examine risk factors for oral HPV infection in United States adults.MethodsUsing 2009‐2014 data from the National Health and Nutrition Examination Survey, 13 981 subjects were examined. Prevalence of oral HPV and individual oncogenic HPV types were described according to race. Multivariable logistic and linear regressions were used to examine the risk factors for infection and coinfection.ResultsOncogenic and nononcogenic oral HPV infections were significantly more prevalent in black subjects. Infections with oral HPV types 16 and 51 were more prevalent in white subjects, whereas HPV types 35 and 58 were more prevalent in black subjects.ConclusionWe identified 4 oral HPV types that differ by race. Future research on HPV types (especially those that differ by race) may help elucidate their potential role in carcinogenesis and cancer disparities.
3D brain magnetic resonance imaging segmentation by using bitplane and adaptive fast marching
Authors: Tuan Tran Anh , Kim Jin Young , Bao Pham The 
Published: May 2018

AbstractDiagnosis using medical images helps doctors detect diseases and treat patients effectively. A system that segments objects automatically from magnetic resonance imaging (MRI) plays an important role when doctors diagnose injuries and brain diseases. This article presents a method for automatic brain, scalp, and skull segmentation from MRI that uses Bitplane and the Adaptive Fast Marching method (FMM). We focus on the segmentation of these tissues, especially the brain, because they are the essential objects, and their segmentation is the first step in the segmentation of other tissues. First, the type of each slice is set based on the shape of the brain, and the head region is segmented by removing its background. Second, the sure region and the unsure region are segmented based on the Bitplane method. Finally, this work proposes an approach for classification that is based on the Adaptive FMM. This approach is evaluated with the BrainWeb and Neurodevelopmental MRI databases and compared with other methods. The Dice Averages for brain, scalp, and skull segmentation are 96%, 80%, and 93%, respectively, on the BrainWeb database and 91%, 67%, and 80%, respectively, on the Neurodevelopmental MRI database.
The analysis of false prolongation of the activated partial thromboplastin time (activator: silica): Interference of C‐reactive protein
Authors: Liu Jie , Li Fanfan , Shu Kuangyi , Chen Tao , Wang Xiaoou , Xie Yaoqi , Li Shanshan , Zhang Zhaohua , Jin Susu , Jiang Minghua 
Published: May 2018

BackgroundTo investigate the effect of C‐reactive protein on the activated partial thromboplastin time (APTT) (different activators) in different detecting systems.MethodsThe C‐reactive protein and coagulation test of 112 patients with the infectious disease were determined by automation protein analyzer IMMAG 800 and automation coagulation analyzer STA‐R Evolution, respectively. The pooled plasma APTT with different concentrations of C‐reactive protein was measured by different detecting system: STA‐R Evolution (activator: silica, kaolin), Sysmex CS‐2000i (activator: ellagic acid), and ACL TOP 700 (activator: colloidal silica). In addition, the self‐made platelet lysate (phospholipid) was added to correct the APTT prolonged by C‐reactive protein (150 mg/L) on STA‐R Evolution (activator: silica) system.ResultsThe good correlation between C‐reactive protein and APTT was found on the STA‐R Evolution (activator: silica) system. The APTT on the STA‐R Evolution (activator: silica) system was prolonged by 24.6 second, along with increasing C‐reactive protein concentration. And the APTT of plasma containing 150 mg/L C‐reactive protein was shortened by 3.4‐6.9 second when the plasma was mixed with self‐made platelet lysate. However, the APTT was prolonged unobviously on other detecting systems including STA‐R Evolution (activator: kaolin), Sysmex CS‐2000i, and ACL TOP 700.ConclusionC‐reactive protein interferes with the detection of APTT, especially in STA‐R Evolution (activator: silica) system. The increasing in C‐reactive protein results in a false prolongation of the APTT (activator: silica), and it is most likely that C‐reactive protein interferes the coagulable factor binding of phospholipid.
Mediation of time perspectives on inclinations to use alcohol and motivation to change relationship
Authors: Wagner Vincent , Acier Didier , Dietlin Jean‐Eric 
Published: May 2018

AbstractObjectivesTrajectories of change accompanying alcohol‐specialized care can be affected by numerous variables. Massive urges to drink can substantially hamper personal motivation to change. However, time perspective could also play an indirect role in this association. This research explores whether time perspectives mediates the relationship between inclinations to use or not to use alcohol and patients’ motivation to change.DesignThe sample included 150 outpatients in care for their problematic alcohol use. Models of mediation were planned.ResultsAt the entry in care, three specific time perspectives, Past Negative, Present Fatalistic, and Future, acted as discrete mediators.ConclusionsThese findings highlight underlying mechanisms connecting inclinations to use or to avoid the substance and the patient's motivation to change. Time perspective could also be an interesting intervention target in existing alcohol‐specialized treatment programs.
Bean dregs‐derived hierarchical porous carbons as metal‐free catalysts for efficient dehydrogenation of propane to propylene
Authors: Hu Zhong‐Pan , Zhang Ling‐Feng , Wang Zheng , Yuan Zhong‐Yong 
Published: May 2018

AbstractBACKGROUNDRecently, nanocarbons (e.g. carbon nanotubes, nanodiamond and mesoporous carbon) were found to be efficient catalysts in dehydrogenation reactions. However, the preparation of these nanocarbons is costly, complicated and time‐consuming. The goal of this study is to exploit a biomass‐derived carbon for propane dehydrogenation.RESULTSBiomass‐derived carbons with hierarchical porous structures and high surface area are prepared via carbonization of bean dregs with NaOH, and operated as metal‐free catalysts for direct dehydrogenation of propane to propylene. The properties of the prepared carbon catalysts are characterized by SEM, TEM, XRD, N2 sorption and XPS techniques, revealing the presence of many nanopores and oxygenated functional groups. The catalytic results show that the resultant carbons exhibit high catalytic activity, selectivity and stability for direct dehydrogenation of propane. The activation temperature can significantly affect the textural properties and surface functional groups of the carbons, and thus, affect their catalytic performance.CONCLUSIONThe excellent catalytic performance can be attributed to the high content of oxygenated functional groups combined with hierarchical porous structure and large surface area of the obtained porous carbons which could provide more accessible active sites. This work demonstrates the flexible utilization of bean dregs‐derived carbons in propane dehydrogenation to propylene. © 2018 Society of Chemical Industry
Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice
Authors: Fairfax Kirsten A , Bolden Jessica E , Robinson Aaron J , Lucas Erin C , Baldwin Tracey M , Ramsay Kerry A , Cole Rebecca , Hilton Douglas J , de Graaf Carolyn A 
Published: May 2018

Abstract
Eosinophils are important in fighting parasitic infections and are implicated in the pathogenesis of asthma and allergy. IL-5 is a critical regulator of eosinophil development, controlling proliferation, differentiation, and maturation of the lineage. Mice that constitutively express IL-5 have in excess of 10-fold more eosinophils in the hematopoietic organs than their wild type (WT) counterparts. We have identified that much of this expansion is in a population of Siglec-F high eosinophils, which are rare in WT mice. In this study, we assessed transcription in myeloid progenitors, eosinophil precursors, and Siglec-F medium and Siglec-F high eosinophils from IL-5 transgenic mice and in doing so have created a useful resource for eosinophil biologists. We have then utilized these populations to construct an eosinophil trajectory based on gene expression and to identify gene sets that are associated with eosinophil lineage progression. Cell cycle genes were significantly associated with the trajectory, and we experimentally demonstrate an increasing trend toward quiescence along the trajectory. Additionally, we found gene expression changes associated with constitutive IL-5 signaling in eosinophil progenitors, many of which were not observed in eosinophils.
Eosinophils in Interleukin-5 transgenic mice can be subdivided by Siglec-F expression, and are transcriptionally distinct.
Cinnamaldehyde and related phenylpropanoids, natural repellents, and insecticides against Sitophilus zeamais (Motsch.). A chemical structure‐bioactivity relationship
Authors: Zaio Yésica P , Gatti Gerardo , Ponce Andrés A , Saavedra Larralde Natalia A , Martinez María J , Zunino María P , Zygadlo Julio A 
Published: May 2018

AbstractBACKGROUNDThe insecticidal and repellent effects on adult Sitophilus zeamais of 12 cinnamaldehyde‐related compounds was evaluated by contact toxicity bioassays and a two‐choice olfactometer. To determine non‐toxicity in mammals, body weight, serum biochemical profiles, liver weight, physiological parameters, sperm motility, and histopathological data were obtained as complementary information in C57BL/6 mice treated with the best natural compound.RESULTSBased on 24 h LC95 and LC50 values, α‐methyl‐cinnamaldehyde and cinnamaldehyde exhibited better insecticidal action than the other compounds. The best repellent effect was observed with α‐bromo‐cinnamaldehyde, which even repelled at the lowest concentration studied (0.28 µmol L−1). The evaluation of a quantitative structure‐activity relationship found a linear relationship between the LC50 values for adult weevil toxicity and dipolo with Q values (giving the difference between orbital electronegativity carbon 1 and orbital electronegativity carbon 3 of the molecule) in cinnamaldehyde‐related compounds. The polar surface and Log P descriptors also revealed a linear relationship with the S. zeamais repellent effect for cinnamaldehyde analogues. Cinnamaldehyde did not show toxicity in the parameters evaluated in mice.CONCLUSIONFrom the phenylpropanoid components studied, the natural compound that had the best insecticidal and repellent action against S. zeamais was cinnamaldehyde. It presented no mammalian toxicity. © 2018 Society of Chemical Industry
Multiscale models of habitat use by mule deer in winter
Authors: Coe Priscilla K. , Clark Darren A. , Nielson Ryan M. , Gregory Sara C. , Cupples Jacqueline B. , Hedrick Mary Jo , Johnson Bruce K. , Jackson Dewaine H. 
Published: May 2018

ABSTRACTMule deer (Odocoileus hemionus hemionus) populations have experienced widespread declines in much of western North America and alteration or loss of habitat could be contributing to these declines. Consequently, understanding habitat features that are important to mule deer is necessary for effective management of the species and their habitat. From 2005–2012 we radio‐marked 452 mule deer with global positioning system collars across 9 distinct winter ranges to evaluate winter habitat use along the east slope of the Cascade Range in south‐central Oregon, USA. Using data from 357 mule deer across 9 analysis areas, we developed regional habitat use models for mule deer on winter range at 3 spatio‐temporal scales: herd range based on 100% minimum convex polygons around deer locations, home range based on 90% kernel density estimates of deer locations, and foraging range based on locations obtained within 2 hours of sunrise or sunset within the boundaries of the home range scale. We assessed habitat use of mule deer using a generalized linear model with a negative‐binomial link function. We validated our models with locations from an independent dataset of 95 deer that wintered within 8 of our analysis areas. Model validation indicated that regional models for all spatio‐temporal scales predicted probability of use moderately to very well. At all spatio‐temporal scales, predicted use by mule deer was greater in areas with forest canopy cover. These findings call into question large‐scale removal of western juniper (Juniperus occidentalis) in Oregon and other portions of western United States to enhance habitat for sagebrush‐dependent wildlife species. Across all spatio‐temporal scales, we documented increased probability of use of areas farther from roads open to motorized vehicle use by mule deer, highlighting the importance of limiting motorized vehicle use and access on mule deer winter range. We also documented increased use of areas with lower snow depth and on moderate slopes by mule deer. Our models can be used in land management planning to spatially predict mule deer distribution and probability of use under alternative management scenarios that affect forest canopy cover or motorized vehicle use on roads while accounting for other physical features of the landscape. Additionally, our models can be used to develop juniper removal projects to mitigate effects on mule deer winter range habitat while benefiting other wildlife. © 2018 The Wildlife Society.
Appropriateness criteria predict outcomes for sinus surgery and may aid in future patient selection
Authors: Beswick Daniel M. , Mace Jess C. , Soler Zachary M. , Ayoub Noel F. , Rudmik Luke , DeConde Adam S. , Smith Timothy L. 
Published: May 2018

ObjectivesAppropriateness criteria to determine surgical candidacy for chronic rhinosinusitis (CRS) have recently been described. This study stratified patients who underwent endoscopic sinus surgery (ESS) according to these new appropriateness criteria and evaluated postoperative improvements among appropriateness categories.MethodsAdult patients with uncomplicated CRS electing ESS were prospectively enrolled in a multi‐institutional cohort study between March 2011 and June 2015 to assess outcomes. Subsequently, appropriateness criteria that consider preoperative medical therapy, 22‐item SinoNasal Outcome Test (SNOT‐22) scores, and Lund‐Mackay computed tomography scores were retrospectively applied.ResultsA total of 92.6% (436 of 471) were categorized as “appropriate” ESS candidates, 3.8% (18 of 471) as “uncertain,” and 3.6% (17 of 471) as “inappropriate.” Among uncertain patients, two‐thirds (12 of 18) had identifiable reasons for undergoing ESS, most commonly oral corticosteroid intolerance (n = 6). Postoperative follow‐up was available for 79% (n = 372). Clinically significant SNOT‐22 improvements occurred in both appropriate and uncertain groups (all P < 0.050) but not among the inappropriate group. The inappropriate group reported less mean improvement in SNOT‐22 total score compared to appropriate (P = 0.008) and uncertain (P = 0.006) groups.ConclusionThe vast majority of patients (∼93%) who underwent ESS in a multi‐institutional research program were identified as appropriate candidates for surgical intervention, as defined by current appropriateness criteria. Valid considerations frequently exist for offering ESS to patients categorized as uncertain. Appropriate and uncertain candidates report similar, clinically significant SNOT‐22 improvements following surgery. Patients classified as inappropriate reported significantly less improvement following ESS. Surgical appropriateness criteria may assist in predicting outcomes of ESS.Level of Evidence2b. Laryngoscope, 2448–2454, 2018
Safety of preoperative ibuprofen in pediatric tonsillectomy
Authors: Michael Alexander , Buchinsky Farrel J. , Isaacson Glenn 
Published: May 2018

ObjectiveOral ibuprofen is believed to be safe and effective after pediatric adenotonsillectomy. There has been little study of its use as a preoperative analgesic. We attempt to document its safety in this setting.Study DesignIndividual case control study.MethodsChildren who underwent tonsillectomy or adenotonsillectomy from January 2013 to December 2015 did not receive preoperative ibuprofen. Those who underwent tonsillectomy or adenotonsillectomy from January 2016 to December 2017 received oral ibuprofen 7 mg/kg preoperatively. Pre‐ and postoperative records were reviewed. Intraoperative bleeding > 50 mL or early postoperative bleeding requiring surgical control were outcome measures. Delayed bleeding events were also recorded.ResultsA total of 217 children met inclusion criteria. Of those, 112 patients did not receive preoperative ibuprofen, and 105 patients did receive preoperative ibuprofen. Mean age was 8.7 years (range: 1–18) in the control/non‐ibuprofen cohort and 8.3 years (range: 1–18) in the ibuprofen cohort. No child experienced significant intraoperative or early postoperative bleeding in the non‐ibuprofen (95% confidence interval [CI] 0–0.027) or in the ibuprofen cohort (95% CI 0– 0.029). Delayed bleeding rates were similar in both groups.ConclusionIn this series, children treated with preoperative ibuprofen did not experience increased bleeding during or soon after tonsillectomy compared to controls. Pain control was not studied in these patients. These favorable safety data argue for a future prospective randomized study of preoperative ibuprofen's effectiveness in reducing pain and opioid requirement after pediatric tonsillectomy.Level of Evidence3b. Laryngoscope, 128:2415–2418, 2018
A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency: Outcomes using a bioabsorbable implant
Authors: Stolovitzky Pablo , Sidle Douglas M. , Ow Randall A. , Nachlas Nathan E. , Most Sam P. 
Published: May 2018

ObjectiveTo examine 6‐month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant.Study DesignProspective, multicenter, nonrandomized, single‐blinded study.MethodsOne hundred and one patients with severe‐to‐extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016–March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s). NOSE scores and visual analog scale (VAS) were measured at baseline and month 1, 3, and 6 postoperatively. The Lateral Wall Insufficiency (LWI) score was determined by independent physicians observing the lateral wall motion video.ResultsForty‐three patients were treated with implant alone, whereas 58 had adjunctive procedures. Seventeen patients reported 19 adverse events, all of which resolved with no clinical sequelae. Patients showed significant reduction in NOSE scores at 1, 3, and 6 months postoperatively (79.5 ± 13.5 preoperatively, 34.6 ± 25.0 at 1 month, 32.0 ± 28.4 at 3 months, and 30.6 ± 25.8 at 6 months postoperatively; P < 0.01 for all). They also showed significant reduction in VAS scores postoperatively (71.9 ± 18.8 preoperatively, 32.7 ± 27.1 at 1 month, 30.1 ± 28.3 at 3 months, and 30.7 ± 29.6 at 6 months postoperatively; P < 0.01 for all). These results were similar in patients treated with the implant alone compared to those treated with the implant and adjunctive procedures. Consistent with patient‐reported outcomes, postoperative LWI scores were demonstrably lower (1.83 ± 0.10 and 1.30 ± 0.11 pre‐ and postoperatively; P < 0.01).ConclusionStabilization of the lateral nasal wall with a bioabsorbable implant improves patients' nasal obstructive symptoms over 6 months.Level of Evidence2b. Laryngoscope, 2483–2489, 2018
Vitamin D intake and survival and recurrence in head and neck cancer patients
Authors: Yokosawa Eva B. , Arthur Anna E. , Rentschler Katie M. , Wolf Gregory T. , Rozek Laura S. , Mondul Alison M. 
Published: May 2018

Objectives/HypothesisWith an unacceptably low 5‐year survival rate and few identified modifiable factors that affect head and neck cancer (HNC) outcomes, HNC survival remains an important public health problem. Vitamin D has been shown to be associated with immune reactivity and improved outcomes for some cancer sites, but findings are mixed, and few studies have examined vitamin D in relation to HNC. This study aimed to assess the association between vitamin D intake and survival outcomes in HNC patients.Study DesignProspective cohort study.MethodsThis study utilized data on 434 HNC patients with valid pretreatment food frequency questionnaire data who participated in the University of Michigan Head and Neck Specialized Program of Research Excellence epidemiology project. Cox proportional hazard models were used to estimate the associations between total, dietary, and supplemental vitamin D intake and HNC outcomes, while adjusting for other known prognostic factors.ResultsAfter multivariable adjustment, we found a statistically significant inverse trend between total vitamin D intake and recurrence (Q4 vs. Q1 hazard ratio: 0.47, 95% confidence interval: 0.20‐1.10, P trend = .048). We observed no association with dietary or supplemental intake separately, and no association was observed with all‐cause or HNC‐specific mortality.ConclusionsThese findings suggest that HNC patients with lower levels of vitamin D intake are at higher risk of recurrence. If borne out in future studies, our results suggest that increased vitamin D intake through dietary intervention or the use of supplements may be a feasible intervention for prevention of recurrence in HNC patients.Level of Evidence2b. Laryngoscope, E371–E376, 2018