bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liquid biopsy: novel technologies and clinical applications
Authors: Reimers Natalie , Pantel Klaus 
Published: November 2018

Abstract
“Liquid biopsy” was introduced as a new diagnostic concept in 2010 for the analysis of circulating tumor cells (CTCs) and has been now extended to material (in particular DNA) released by tumor cells in the peripheral blood of cancer patients. Over the past decade, various methods have been developed to detect CTCs and ctDNA in the peripheral blood of cancer patients.
Long-Term Dissolution of Glass Fibers in Water Described by Dissolving Cylinder Zero-Order Kinetic Model: Mass Loss and Radius Reduction
Authors: Krauklis Andrey E. , Echtermeyer Andreas T. 
Published: November 2018

AbstractGlass fibers are degraded when they are exposed to water. In this work, a model is developed that uses zero-order kinetics for predicting a decreasing glass fiber radius. The model is used to describe experimental test results of almost half a year long-term dissolution of R-glass fibers. The model is able to predict both mass loss and radius reduction kinetics using the same four parameters: initial fiber radius (r0), rate constants for both short-term degradation $\left( K_{0}^{I} \right)$and steady-state degradation $\left( K_{0}^{II} \right)$and the time when steady-state kinetics are reached (tst). All parameters can be easily determined from initial radius measurements and mass loss evolution in time. Elements released and detected during degradation were Na, K, Ca, Mg, Fe, Al, Si and Cl. Rate constants were obtained for individual ion release and for the total mass loss. The contribution of Si to the total mass loss was the largest (56.1% by mass). It governed the dissolution process. The kinetics of radius reduction are also reported. The radius reduction was found to be linear with time during the steady-state dissolution. The zero-order kinetic constant and the density of the glass describe the rate (proportionality) of the dissolution.
Facile generation of antibody heavy and light chain diversities for yeast surface display by Golden Gate Cloning
Authors: Roth Lukas , Grzeschik Julius , Hinz Steffen C. , Becker Stefan , Toleikis Lars , Busch Michael , Kolmar Harald , Krah Simon , Zielonka Stefan 
Published: November 2018

Abstract
Antibodies can be successfully engineered and isolated by yeast or phage display of combinatorial libraries. Still, generation of libraries comprising heavy chain as well as light chain diversities is a cumbersome process involving multiple steps. Within this study, we set out to compare the output of yeast display screening of antibody Fab libraries from immunized rodents that were generated by Golden Gate Cloning (GGC) with the conventional three-step method of individual heavy- and light-chain sub-library construction followed by chain combination via yeast mating (YM). We demonstrate that the GGC-based one-step process delivers libraries and antibodies from heavy- and light-chain diversities with similar quality to the traditional method while being significantly less complex and faster. Additionally, we show that this method can also be used to successfully screen and isolate chimeric chicken/human antibodies following avian immunization.
Assessment of dental caries and gingival status among a group of type 1 diabetes mellitus and healthy children of South India – a comparative study
Authors: Babu K.L. Girish , Subramaniam Priya , Kaje Keerthan 
Published: November 2018

AbstractBackgroundDiabetes mellitus is a metabolic disorder. However, dental caries and periodontal health have not attracted much interest in diabetic patients. This study was carried out to assess the dental caries status and gingival health status in children with type 1 diabetes mellitus (T1DM).MethodsThe study group consisted of 80 children, aged 6–18 years, with T1DM. The dental caries status was recorded using the World Health Organisation (WHO) criteria. Gingival health was assessed using the Loe and Silness gingival index (GI). Data obtained were subjected to statistical analysis.ResultsThe mean dental caries status for primary (decayed, extracted, filled teeth [deft]) and permanent dentition (decayed, missing, filled teeth [DMFT]) scores in diabetic children were 0.44±1.28 and 1.26±2.49, respectively. The GI scores of diabetic children were 0.33±0.48. GI in the study group significantly correlated with DMFT (p<0.001) and deft (p≤0.05).ConclusionsDental caries in primary dentition was lower in diabetic children but was not statistically significant, whereas dental caries in permanent dentition was significantly higher. The gingival condition of diabetic children was healthy.
Thromboembolic complications following tissue plasminogen activator therapy in patients of acute ischemic stroke - Case report and possibility for detection of cardiac thrombi
Authors: Yamaguchi Junko , Kinoshita Kosaku , Hirabayashi Marina , Hori Satoshi , Furukawa Makoto , Sakurai Atsushi 
Published: November 2018

Abstract
Many reports focus on the probability of intracranial hemorrhage as a complication after recombinant tissue plasminogen activator (rt-PA) therapy. However, thromboembolic complications are not well discussed. We experienced a case in which severe thromboembolic complications occurred in the right radial and right ulnar artery. Arterial fibrillation was observed in this case. If multiple thrombi exist in the atrium or ventricle, multiple small embolic particles may appear following thrombolytic therapy, and that may be a potential risk of secondary thromboembolic complications due to incomplete dissolution of thrombi. Transesophageal echocardiography is a standard method to detect intracardiac sources of emboli in the case of arterial fibrillation. Transesophageal echocardiography is, however, an invasive method for patients with ischemic stroke during rt-PA therapy. High resolution enhanced CT could be a useful tool and may be a reliable alternative to transthoracic echocardiography. Careful assessment of thromboembolic complications following rt-PA therapy in patients with arterial fibrillation is needed. In this case report and mini review, we would like to discuss about the accurate diagnostic methods to detect cardiac or undetermined embolic sources and provide expedited stroke care. These embolic sources may be more readily discovered during rt-PA therapy within the limited therapeutic time window.
An activity window model for social interaction structure on Twitter
Authors: Zhang Jun , Xia Haoxiang , Wang Le-zhi , Li Peng , Quadir Benazir 
Published: November 2018

Abstract
The development of online social environments has changed the manner of social interaction and communication, which are driven by individual human actions. Thus temporal variations in interaction networks are deeply impacted by the temporal dimension of human activity. In this paper, we address this issue through a detailed analysis on the retweets and comments of 550,000 Twitter users. We propose a temporal network model to represent the interaction network on Twitter, in which each node contains an activity window and the emergence of the edges between nodes are dependent on it. Specifically, the activity window is defined as the backtracking length from the message flow posted by the user’s friend, which represents the user’s social ability. It complies with a power-law distribution with an exponential cut-off. The interaction network is sparser and more clustered than the followee-follower network, in which the interaction stability and burstiness fluctuate with the activity window or with the degree to which the two users are involved in the communication. Finally, the effect of activity window on the aggregating degrees of the interaction network is examined.
Sémiotique de la /lumière/ et de l’/obscurité/ de L’Ile de la fée d’Edgar Poe, et Pierre et Jean de Guy de Maupassant, à La Route d’Altamont de Gabrielle Roy, et L’Assassinat de la Via Belpoggio d’Italo Svevo
Authors: Navarette Pierre-Antoine 
Published: November 2018

Résumé Le présent article analyse d’un point de vue sémiotique les rapports entre la /lumière/ et l’/obscurité/ et les catégories discursives au sein d’un corpus de quatre textes de la littérature du dix-neuvième et vingtième siècle. Il s’agit de montrer que les propriétés physiques et sensibles fondent les structures sémio-narratives et orientent les catégories axiologiques, thymiques, spatiales et temporelles. Autrement dit, on observe une primauté de la lumière et de l’obscurité en tant que catégories organisées en structure élémentaire qui génère, par un système de conversion, les unités abstraites et concrètes aux niveaux successifs du parcours génératif.
Die Größe einer Genossenschaftsbank als Einflussfaktor auf risikoadjustierte Kapitalstruktur- und Ergebniskennzahlen
Authors: Helms Nils 
Published: November 2018

Zusammenfassung
Genossenschaftsbanken befinden sich aufgrund der regulatorischen Verschärfungen, der Niedrigzinsen und der Digitalisierung in einem schwierigen Marktumfeld. Durch diese Herausforderungen ist eine Debatte entstanden, inwieweit die Belastungen für die Kreditinstitute in Abhängigkeit von der Größe ungleichmäßig ausfallen. Dieser Beitrag untersucht, wie sich Genossenschaftsbanken unterschiedlicher Größen in diesem herausforderndem Marktumfeld seit dem Jahr 2010 in Bezug auf verschiedene Kennzahlen entwickeln. Die Analyse zeigt, dass die Aussage, kleine Kreditinstitute könnten grundsätzlich nicht gegenüber größeren Instituten bestehen, zu kurz greift.
Ein Ansatz zur Erklärung des Wachstums der Mitgliederzahlen bei Kreditgenossenschaften
Authors: Reichel Richard 
Published: November 2018

Zusammenfassung
Die deutschen Kreditgenossenschaften verzeichnen seit mehreren Jahrzehnten einen stetigen Mitgliederzuwachs. Über die Bestimmungsfaktoren dieses Wachstumsprozesses ist jedoch wenig bekannt. Dieser Beitrag unternimmt einen ersten Versuch, das Wachstum der Mitgliederzahlen durch die Faktoren „Fusionsaktivität“ und „Dividendenrendite“ zu erklären. Es stellt sich heraus, dass die absolute und die relative Dividendenhöhe keine Rolle für den Mitgliederzuwachs spielt. Fusionen führen hingegen tendenziell zu steigenden Mitgliederzahlen.
Monitoring the solvation process and stability of Eu2+ in an ionic liquid by in situ luminescence analysis
Authors: Ruiz Arana Laura , Olchowka Jacob , Terraschke Huayna 
Published: November 2018

Abstract
Ionic liquids (ILs) offer the remarkable possibility of the direct synthesis of Eu2+-doped nanophosphors in solution, under atmospheric conditions, without the necessity of a high-temperature post-synthetic reduction from its trivalent oxidation state. This work uses for the first time in situ luminescence measurements for monitoring the solvation process of Eu2+ from the solid salt to the IL and its stability against oxidation under atmospheric conditions. Upon the addition of EuBr2 to 1-butyl-3-methyl-imidazolium tetrafluoroborate, the formation of the solvation shell is detected by the shift of the emission band at approximately 24 100 cm−1 assigned to the 5d→4f electronic transitions of Eu2+ within EuBr2 to approximately 22 000 cm−1, assigned to Eu2+ within BminBF4, tracking the time-dependent influence of the Eu2+ coordination environment on the crystal field splitting of its d orbitals. Even though the solubility of EuBr2 was demonstrated to be improved by reducing the concentration and increasing the temperature to 60°C, the performance of reactions at room temperature is recommended for future synthesis of Eu2+ materials in ILs due to the slight oxidation to Eu3+ observed upon heating.
Memórias autobiográficas evocadas por música: Oficinas para idosos com níveis de escolaridade e socioeconômico baixos
Authors: Fernandes Katarina Duarte , Passarini Luisiana Baldini França , Tanelli Letícia , Da Silva Júnior José Davison , Vanzella Patrícia Maria , Carthery-Goulart Maria Teresa 
Published: November 2018

O projeto ATIVAMENTE-UFABC tem como objetivo estimular a autonomia e melhorar a qualidade de vida dos idosos por meio da oferta de oficinas com diferentes tipos de treinos cognitivos. Os programas desenvolvidos consistem de atividades que buscam otimizar o funcionamento da atenção e memória por meio de ações socioeducativas e atividades teórico-práticas que incluem a aplicação de estratégias para maior funcionalidade e melhor autoestima em relação ao próprio potencial cognitivo. Entre essas ações, temos o AtivAmente-Musical, oficinas que por meio da música promovem o acesso a memórias autobiográficas como mecanismo para treino cognitivo, melhora do humor e resgate da identidade. No presente relato, descrevemos a experiência AtivAmente Musical ofertada a um grupo de idosos de baixo nível educacional e socioeconômico de uma ONG de São Bernardo do Campo/SP. Ao longo de um mês, foram realizadas quatro sessões (uma por semana) de intervenção com atividades musicais que estimulavam evocações de memória autobiográfica. Analisando os resultados dos questionários de sintomas de depressão, ansiedade e testes cognitivos aplicados antes e após a intervenção foi possível verificar uma robusta melhora no estado de ânimo dos participantes. Este projeto é considerado socialmente relevante devido à possibilidade de melhorar a qualidade de vida das pessoas através da intervenção musical e levar conhecimento à comunidade sobre o assunto , além de engajar alunos de graduação e pós-graduação a aprenderem sobre esses assuntos na prática.
GEMAS, JOIAS, OURIVESARIA E CONTEMPORANEIDADE: GEMOLOGIA DA CIÊNCIA À ARTE
Authors: Lourenço Cátia De Sousa , Campos Ana Claudia Borges , Miguel Maximialiano Calderari 
Published: November 2018

Esse ensaio pressupõe a arte como uma prática contínua e articulada, potencializando o ser humano como cidadão pleno em sua dimensão planetária. Apresenta a exposição Gemologia da Ciência à Arte de modo a engranzam algumas provocações no ambiente não formal de aprendizagem - a Biblioteca Central Fernando de Castro Moraes. Expressão e significância são questionados a arte gemológica e seu simbiose com a beleza, raridade, exoticidade das possibilidades e apresentações. O ensaio adentra na significância vivida, pensada, sentida e compartilhadas por diversos profissionais em prol da ação extensionista inerente a uma exposição e mostra coletiva. Fotoetnografia e expressão, razão e sensibilidade são os eixo essenciais que norteiam o papel da universidade na promoção de culturas acessíveis, seja pela conjectura de instrumentos e meios que causem a integração dos grupos sociais, seja pelo trabalho com comunidades habitualmente alijadas dos processos e produtos culturais na perspectiva de construção de uma sociedade mais inclusiva. Em suma, a memória visual propõem visibilizar uma ação do curso de gemologia da Universidade Federal do Espírito Santo e as suas iniciativas criativas.
Financeirização e estratégia: narrativa e números
Authors: Matsuda Patricia Mari 
Published: November 2018

Os autores desse livro fazem parte do grupo de estudos denominado CRESC - Centre for Research on Socio-Cultural Change, das quais os pesquisadores do grupo interdisciplinar realizam abordagens das ciências sociais e das humanidades em geral.A presente obra segue a mesma linha, ao utilizar métodos de pesquisa quantitativos e qualitativos para avaliar a dinâmica das mudanças socioculturais da década de 90 e o início dos anos 2000.O livro de Froud et. al. (2006) é indicado como uma referência para aqueles que se dedicam a compreensão dos estudos do mercado de capitais na estratégia corporativa. Froud et. al. (2006) realizou estudos empíricos modelos moldados mais na descrição do que na dedução em três casos detalhados de três empresas: General Electric, Ford e GlaxoSmithKline.
Reflexiones sobre la construcción del objeto de estudio: el trabajo infantil en la Triple Frontera entre Argentina, Brasil y Paraguay
Authors: Zsögön Cecilia 
Published: November 2018

Un problema metodológico y epistemológico central en la producción de conocimiento científico es la construcción del objeto de estudio, que no debe confundirse con un objeto preconstruido, producto del sentido común. Bourdieu nos alerta sobre el cuidado que debemos tener para distinguir estos artefactos de los objetos científicos. En este trabajo reflexionamos acerca de dichas dificultades en base a las experiencias producto de la construcción del objeto de estudio para mi tesis de doctorado sobre el trabajo infantil en la región de la Triple Frontera entre Argentina, Brasil y Paraguay. Para ello repasamos algunos de los desafíos cognoscitivos que implicó la investigación, así como el potencial y limitaciones de las técnicas utilizadas y sus diversas implicaciones. Bourdieu menciona que previo a todo conocimiento riguroso se encuentra el conocimiento de los instrumentos de conocimiento y que “el sociólogo está siempre expuesto a aplicar al mundo social categorías de pensamiento que han sido inculcadas en su pensamiento por el mundo social” (1997:64). De ahí la importancia del análisis de la producción de nuestros instrumentos de conocimiento y la relevancia, no tanto de los resultados, sino de los procesos a partir de los cuales estos resultados fueron obtenidos.
POR UMA ÉTICA CRIANCEIRA DAS CIDADES
Authors: Clasen Carolina , Rocha Eduardo 
Published: November 2018

No intento de dar pistas que tangenciam a multiplicidade das condições urbanascontemporâneas, a principal reflexão discorrida aqui é diante da proposição de uma escala da experiência da rua que se faz adversa ao que vem sendo indicado na hegemonia dos usos do espaço público. O eixo dorsal para uma experiência em devir, que se faça a partir de uma ética crianceira para a multiplicidade, são corporalidades in-fantis – crianças na faixa etária de até 12 anos. E à ética e suas relações agenciadas com a urbanidade, são recorridos os autores da filosofia francesa contemporânea: Spinoza, Gilles Deleuze e Agamben.Palavras-chave: urbanismo contemporâneo, ética, crianças, infância.
STRATEGI DAN KEBIJAKAN PRODUKSI PADA BUDIDAYA IKAN NILA BERDAYA SAING
Authors: Hadie Lies Emmawati , Kusnendar Endhay , Priono Bambang , Sinarni Dewi Raden Roro Sri Pudji , Hadie Wartono 
Published: November 2018

Kontribusi perikanan budidaya termasuk ikan nila terhadap ekonomi perikanan dan ekonomi nasional, menunjukkan nilai strategis dengan Nilai Tukar Pembudidaya Ikan mencapai 99,72. Khususnya kontribusi komoditas nila mencapai 30,72 % dari total produksi ikan bersirip nasional tahun 2015. Hasil analisis menunjukkan bahwa strategi jangka pendek yang diperlukan adalah penerapan tehnik budidaya yang efisien pada komoditas nila unggul merupakan kebutuhan mendesak untuk mencapai produktivitas yang kompetitif. Strategi jangka menengah yang perlu dipertimbangkan adalah pemanfaatan tambak darat untuk budidaya nila sebagai upaya perluasan lahan budidaya selain kolam dan karamba jaring apung yang telah eksis. Kebutuhan induk unggul nila dapat di produksi secara massal melalui beberapa brodstock center milik pemerintah maupun perusahaan swasta yang telah beroperasi. Antisipasi kebijakan dalam merespon Inpres No.7 Tahun 2016 adalah pengembangan industri pakan ikan skala kecil dan pemanfaatan induk unggul dalam perspektif pertumbuhan dan perluasan yang mencakup dua aspek kebijakan sebagai berikut : (a) Pengembangan produksi berbasis potensi pasar yang dikomplemen dengan perbaikan sistem budidaya ikan, dan (b) Pengembangan inovasi kelembagaan dan sistem insentif dalam mendukung ketersediaan dan akses sarana produksi utama pada usaha budidaya nila skala kecil. The contribution of aquaculture including tilapia to fishery economy and national economy shows strategic value with Fisheries Term of Trade reaching 99.72. Especially the contribution of tilapia commodities reaches 30.72% of the total national finned fish production in 2015.Result of the analysis showed that application of efficient cultivation techniques to superior tilapia commodities is a short-term strategy to achieve competitive productivity. The medium-term strategy is the use of terrestrial ponds for tilapia cultivation as an effort to expand cultivation land in addition to ponds and floating net cages that already exist. The needs of superior tilapia parents can be mass produced through several government broodstock centers and private companies that have been operating. Anticipation of policies in responding to Presidential Decree No.7 of 2016 is the development of small-scale fish feed industry and utilization of superior broodstock in the perspective of growth and expansion which includes two aspects of policy as follows : (a) Development of market-based potential production that is complemented by improved fish farming systems; and (b) Development of institutional innovations and incentive systems in support of availability and access to key production facilities on small-scale tilapia aquaculture.
STUDY INTO STRUCTURE AND PROPERTIES OF SOLDERS BASED ON ALUMINUM AND ZINC IN THE FORM OF SMALL-SECTION CAST BARS
Authors: Nikitin K. V. , Timoshkin I. Yu. , Nikitin V. I. 
Published: November 2018

The study covers Al–Cu–Si (A34 grade) and Zn–Al–Cu (Welco52 grade) solders. It is found that A34 solder (Al–28%Cu–6%Si) melts and crystallizes in a narrow range of temperatures (~18 °C). Solidus and liquidus temperatures of A34 solder are ~508 °С and ~526 °С, respectively. Zn–Al–Cu (Zn–4%Al–2,5% Cu) solder has a eutectic composition, so it melts and crystallizes at a constant temperature of ~389 °С. Densities of investigated solders in their liquid and solid states are studied. A34 solder has a density of 3,02 and 3,32 g/cm3 , respectively. Zinc solder density is 6,28 g/cm3 in the liquid state, and 6,69 g/cm3 in the solid state. The influence of casting conditions on the structure of cast alloys in the form of bars with cross sections of 13, 10, and 5 mm2 was investigated. Main structural components of solder alloys reduce in size as cross sections decrease. The aluminium-based solid solution dendrites and CuAl2 phase are reduced in the A34 solder microstructure. In zinc solders, the most severely reduced ones are zinc-based solid solution dendrites. The best castability is observed in melts obtained from 5 mm2 section bar solders with studied sample gaps of 2,0, 1,5 and 1,0 mm. Eutectic zinc solder features better castability in comparison with A34: castability of the melt obtained from the 5 mm2 section zinc solder rod with a sample gap width of 2,0 mm is 100 % (for A34 melt solder obtained from a rod of the same cross section it was 98 %). Experiments on soldering AK12 alloy plates and 3003 alloy sheets demonstrated that there is a tight border in the solder/base material system and no any defects such as pores or unsoldered areas. There was a slight interpenetration of solder alloys into base materials, especially when soldering AK12 cast plates.