bluuebunny/crossref_metadata_2025_split huggingface dataset:
Would You Be Surprised if This Patient Died in the Next 12 Months? Using the Surprise Question to Increase Palliative Care Consults From the Emergency Department
Authors: Zeng Henry , Eugene Paul , Supino Mark 
Published: August 2019

Background: There is a growing movement to increase palliative care consults from the emergency department (ED) to reduce healthcare costs and improve quality of life. The surprise question is a screening tool that emergency medicine physicians may be able to use towards achieving this goal. Objective: The objectives of this study were to increase awareness of hospice and palliative care medicine (HPM) among emergency medicine (EM) providers and to evaluate whether this heightened awareness increased palliative care consults among participating emergency medicine providers. Methods: We conducted an anonymous convenience sample survey and two educational interventions about HPM including the surprise question among emergency medicine resident and attending physicians at a large urban public academic quaternary care center from July to November 2018. A report of palliative care consults ordered between August 1, 2017 and January 1, 2019 was generated from the electronic health records used by the hospital. The number of palliative care consults made before and after the educational intervention was compared. Results: After the first educational intervention centered on the surprise question, palliative care consults from the ED increased from an average of 2.25 per month (range 0 to 8, SD: 2.38) to 12.67 per month (range 9 to 19, SD: 4.01, p < .001). Conclusion: Educating EM physicians about the surprise question can increase the number of palliative care consults from the ED, thereby potentially improving patient care and decreasing costs by avoiding unwanted healthcare interventions.
Keys to Recruiting and Retaining Seriously Ill African Americans With Sickle Cell Disease in Longitudinal Studies: Respectful Engagement and Persistence
Authors: Suarez Marie L. , Schlaeger Judith M. , Angulo Veronica , Shuey David A. , Carrasco Jesus , Roach Keesha L. , Ezenwa Miriam O. , Yao Yingwei , Wang Zaijie Jim , Molokie Robert E. , Wilkie Diana J. 
Published: August 2019

Objectives: Sickle cell disease (SCD) is a serious illness with disabling acute and chronic pain that needs better therapies, but insufficient patient participation in research is a major impediment to advancing SCD pain management. The purpose of this article is to discuss the challenges of conducting an SCD study and approaches to successfully overcoming those challenges. Design: In a repeated-measures, longitudinal study designed to characterize SCD pain phenotypes, we recruited 311 adults of African ancestry. Adults with SCD completed 4 study visits 6 months apart, and age- and gender-matched healthy controls completed 1 visit. Results: We recruited and completed measures on 186 patients with SCD and 125 healthy controls. We retained 151 patients with SCD with data at 4 time points over 18 months and 125 healthy controls (1 time point) but encountered many challenges in recruitment and study visit completion. Enrollment delays often arose from patients’ difficulty in taking time from their complicated lives and frequent pain episodes. Once scheduled, participants with SCD cancelled 49% of visits often because of pain; controls canceled 30% of their scheduled visits. To facilitate recruitment and retention, we implemented a number of strategies that were invaluable in our success. Conclusion: Patients’ struggles with illness, chronic pain, and their life situations resulted in many challenges to recruitment and completion of study visits. Important to overcoming challenges was gaining the trust of patients with SCD and a participant-centered approach. Early identification of potential problems allowed strategies to be instituted proactively, leading to success.
Adherence to Orthodontic Treatment in Youth With Cleft Lip and/or Palate
Authors: Crerand Canice E. , Da Silveira Adriana C. , Kapa Hillary , Litteral Jennifer , Markey Mia K. , Mercado Ana , Scott Michelle 
Published: August 2019

Objective: To identify rates of nonadherence to orthodontic treatment among youth with cleft lip and/or palate (CL/P) and to compare demographic and clinical characteristics of patients categorized as adherent or nonadherent. Design: Retrospective chart review. Setting: Orthodontic treatment program affiliated with a US pediatric hospital-based craniofacial team. Participants: Medical charts of 54 patients with CL/P beginning phase I or phase II orthodontics between 2011 and 2014 (54% male; mean age: 11.7 ± 3.2 years) were reviewed. Main Outcome Measure(s): Data abstracted included demographic and clinical characteristics. Patients were classified as nonadherent based upon treatment termination due to nonadherence, treatment courses extending beyond 3 years, and information about missed appointments, poor oral hygiene, and broken appliances. Results: In all, 24% had treatment terminated due to nonadherence and were significantly more likely to have behavioral health diagnoses ( P = .01) or visits ( P = .02) and social work consults ( P = .01) than patients without termination. Thirty-seven percent had treatment courses beyond 3 years; youth with longer courses were significantly more likely to have cleft lip and palate versus cleft palate only or cleft lip ( P = .03). Patients who missed more than 4 appointments were less likely to have behavioral health diagnoses ( P < .01) compared to those with fewer missed appointments. Poor hygiene and broken appliance notations were common. Youth with poor hygiene notations were significantly older ( P < .01) at treatment initiation than those without notations. Conclusions: Nonadherence was associated with diagnosis, age, and history of behavioral health or social work involvement. An understanding of adherence and relationships with clinical and demographic factors can inform clinical care and support intervention development to improve outcomes.
Molding Conscious Leaders
Authors: Lokhande Madhavi , Cadotte Ernest R. , Agrawal Bindu 
Published: August 2019

Innovation in education is important for developing the next generation of business leaders who also have to be innovators, creative thinkers and managers who will be more responsible towards society. The role of a company is to serve other stakeholders such as staff, clients, suppliers and society besides increasing the wealth of shareholders. In an era of continuous erosion of natural resources due to the progress of mankind, doing business following the path of conscious capitalism may create a competitive edge. The challenge is to orient the mindset of management students to mold them as conscious leaders. In 2009, Dr. Raj Sisodia and Conscious Capitalism Inc. asked Dr. Ernie Cadotte to create a new simulation to illustrate and reinforce the key tenets of the Conscious Capitalism movement. Business managers have a broad variety of conflicting issues to deal with, including product sustainability and reliability, environmental concerns, employee morale and corporate responsibility. The challenge for Cadotte and Sisodia was to develop a new pedagogy for learning to manage a full-enterprise business while addressing the conscious opportunities, situations and problems. In 2011, Cadotte created a game ( Conscious Capitalism in the Marketplace) that simulates the challenges a business manager has to face in today’s world. It is a ‘unique pedagogy’ and an innovative teaching practice that works on the ‘learning-by-doing’ method. This article will be an evidence-based case study of that simulation and its use with the next-generation managers.
Community Participation with Trust: Evidence from a Framed Lab-in-field Experiment with Hybrid Game Model
Authors: Mitra Santanu , Das Abhishek , Gupta Gautam 
Published: August 2019

Out of the 104 islands of Indian Sundarbans, 54 are inhabited. These islands have mud embankments which protect them from intrusion of river and sea water and have made human settlement possible in these islands. Once the embankments were protected from tidal and storm surges by a layer of mangrove forests. But now the mangrove cover has vanished and consequently the embankments are frequently eroded or develop breaches being directly exposed to tidal and storm surges. One way to protect these mud embankments is to recreate mangrove plantations along the toe-line on the outer side of the embankments. This article uses a framed lab-in-field experiment to measure inclination towards community participation in regenerating common pool resources (CPRs), specifically regeneration of mangrove forest on the outer side of the embankments. The 320 subjects who participated in the experiment were villagers from different islands in the Indian Sundarbans. The experiment is a hybrid of the simple Public Goods Game with Voluntary Contributions Mechanism (VCM) and the Trust Game. The first is used to measure inclination towards contributing resources and effort for generation of CPRs and the second is to see if the participants trust others not to extract from the regenerated CPR and if such trust is reciprocated. The results show that voluntary contributions, contrary to theoretical prediction of free riding, are significantly high, though less than when there is no extraction. Trust levels are also quite high and a third of such trust is reciprocated. JEL Codes: C92, H40, Q23
A Study on Sexual Functioning in Patients Who Have Undergone Coronary Artery Bypass Grafting (CABG)
Authors: D. Ramya Shruthi , S. Sunil Kumar , Shetty Shyam Prasad , Desai Nagaraj , Rao T. S. Sathyanarayana 
Published: August 2019

Introduction: Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. Patients with coronary artery disease (CAD) have more than twofold risk of sexual dysfunction compared with age-matched healthy persons. Coronary artery bypass graft (CABG) surgery benefits in CAD populations are well established. Erectile dysfunction (ED) in men and arousal difficulties in women are highly prevalent in CAD, yet it is frequently under-recognized and under-diagnosed in clinical practice. A further study on the relation between CABG and sexual functioning is not much explored, hence the need for the study. Materials and Method: It is a cross-sectional study conducted in JSS Hospital, Mysuru, Karnataka. A total of 54 consecutive patients who have undergone CABG were considered. Informed and written consent was taken. After stabilization and thorough checkup by the attending cardiologist, interview was conducted. The patients were assessed on a structured and validated pro forma, for males International Index for Erectile Function (IIEF) and for females Female Sexual Function Index (FSFI) were used. ANOVA and Student’s t test, statistical software SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Systat 12.0, and R environment ver.2.11.1 were used for statistical analysis. Results: Of the 54 study subjects, in males, 69.4% had mild to moderate ED, 52.8% had mild orgasmic dysfunction, 44.4% had moderate desire dysfunction, 50% had mild to moderate dysfunction of intercourse satisfaction, and 44.4% had mild to moderate and moderate dysfunction in overall satisfaction. In females, one or the other forms of sexual dysfunction were present in all the female study subjects; among them, 66.7% had arousal difficulties, 44.4% had lubrication, orgasm, and satisfaction problems and pain difficulties. Conclusion: The results obtained in this study showed an increased prevalence rate of sexual dysfunction in patients who have undergone CABG. Hence addressing the concerned issues during the stay in the hospital is necessary for the better outcomes.
Pore structure characteristics and its effect on adsorption capacity of Niutitang marine shale in Sangzhi block, southern China
Authors: Wang Xinghua , Dahi Taleghani Arash , Ding Wenlong 
Published: August 2019

Characteristics of shale pore structures may play an important role in natural gas accumulation and consequently estimating the original gas in place. To determine the pore structure characteristics of Niutitang marine shale in the Sangzhi block, we carried out [Formula: see text] adsorption-desorption (LP-[Formula: see text]GA), [Formula: see text] adsorption (LP-[Formula: see text]GA), and methane isothermal adsorption on shale samples to reveal the pore size distribution (PSD) and its impact on the adsorption capacity. Results indicate that the Niutitang Shale is in stages of maturity and overmaturity with good organic matter, and they also indicate well-developed interparticle, intraparticle, and organic pores. Quartz and clay are found to be the main minerals, and the high illite content means that the Niutitang Shale is experiencing the later stage of clay mineral transformation. Various-sized shale pores are well-developed, and most of them are narrow and slit-like. For pores with diameters of 2–300 nm measured with LP-[Formula: see text]GA, mesopores (2–50 nm) contribute most of the total specific surface area (SSA) and total pore volume (TPV) in comparison to macropores (50–300 nm). For micropores ([Formula: see text]) tested by LP-[Formula: see text]GA, the PSD appears to be multimodal; shale pores of 0.50–0.90 nm diameter contribute most of the SSA and TPV. [Formula: see text]-SSA and [Formula: see text]-SSA indicate positive correlations with their corresponding TPV. The total organic matter (TOC) has good correlation with the SSA and TPV of micropores. The Langmuir volume positively correlates with the total SSA. Additionally, the TOC content has a good correlation with the Langmuir volume, which is consistent with the observation of well-developed fossils of diatoms and organic pores. As an important source of organic matter, more diatoms mean more organic matter, larger TOC values and quartz content, larger SSA and TPV of micropores, and, of course, stronger shale adsorption capacity. The results provide important guidance for the exploration and development of shale gas existing in the Sangzhi block.
Coercion and Choice
Authors: Camiscioli Elisa 
Published: August 2019

AbstractThis article employs police investigations of the “traffic in women” between France and Argentina in the first three decades of the twentieth century to highlight the multiple narratives in play when contemporaries talked about trafficking and relayed their experiences of it. While the dominant narrative of “white slavery” in the late nineteenth and early twentieth centuries emphasized coercion, sexual exploitation, and victimization, many young working-class women described the journey to Argentina in terms of perceived opportunity, whether for money, travel, or freedom. This is not to downplay the social and economic vulnerability of these women and the precarious lives they led in French and Argentine cities. Instead, the article emphasizes the inadequacy of many existing frameworks for discussing sex trafficking, and prostitution more generally, as they rely too heavily on a stark division between coercion and choice.Cet article repose sur une analyse d'enquêtes de police portant sur la « traite des femmes » entre la France et l'Argentine durant le premier tiers du vingtième siècle. Il met l'accent sur la multiplicité des discours évoquant la traite, et l'expérience des femmes impliquées. Si, à la fin du dix-neuvième et au début du vingtième siècle, le discours dominant à propos de la « traite des blanches » souligne la coercition, l'exploitation sexuelle et la victimisation, de nombreuses femmes appartenant à la classe ouvrière décrivent leur périple en Argentine comme une opportunité de gagner plus d'argent, de voyager, ou de saisir leur liberté. Cet article ne vise cependant à minimiser ni le rôle de la vulnérabilité économique et sociale de ces femmes, ni leur vie précaire dans les villes de France et d'Argentine. Il cherche plutôt à mettre en évidence le caractère inadapté des différents paradigmes existants pour aborder le sujet du trafic sexuel, et plus généralement de la prostitution, ainsi que la manière dont ces paradigmes reposent sur une division trop marquée entre le choix et la contrainte.
Independent evolution for sex determination and differentiation in the DMRT family in animals
Authors: Mawaribuchi Shuuji , Ito Yuzuru , Ito Michihiko 
Published: August 2019

ABSTRACT
Some DMRT family genes including arthropod dsx, nematode mab-3, and vertebrate dmrt1 are involved in sex determination and/or differentiation in bilaterian animals. Although there have been some reports about evolutionary analyses of the family by using its phylogenetic trees, it is still undecided as to whether these three sex determination-related genes share orthologous relationships or not. To clarify this question, we analyzed evolutional relationships among the family members in various bilaterians by using not only phylogenetic tree analysis, but also synteny analysis. We found that only four genes, dmrt2a/2b, dmrt3, dmrt4/5 and dmrt93B were commonly present in invertebrate bilateria. The syntenies of dmrt2a/2b-dmrt3 and dmrt4/5-dmrt93B are conserved before and after two rounds of whole genome duplication in the ancestral vertebrate. Importantly, this indicates that dmrt1 must have appeared in the common vertebrate ancestor. In addition, dmrt1, dsx, or mab-3 formed each different cluster at a distance in our phylogenetic tree. From these findings, we concluded that the three sex determination-related genes, dmrt1, dsx, and mab-3 have no orthologous relationships, and suggested independent evolution for sex determination and differentiation in the DMRT gene family. Our results may supply clues about why sex-determining systems have diverged during animal evolution.
Non-AIDS defining malignancies in the combination ART era: immunological and socio-behavioral risk factors
Authors: Ruffieux Yann , Chammartin Frédérique , Feller Anita , Schmidlin Kurt , Rohrmann Sabine , Staehelin Katharina , Bouchardy Christine , Bucher Heiner C. , Hasse Barbara , Cavassini Matthias , Calmy Alexandra , Wandeler Gilles , Scherrer Alexandra , Bohlius Julia , Egger Matthias 
Published: August 2019

Background: Since the advent of combination antiretroviral therapy (cART), non-AIDS defining malignancies (NADM) have become increasingly important. We examined risk factors for NADM, including immunological, virological and socio-behavioral characteristics. Methods:We linked the Swiss HIV Cohort Study (SHCS) with cancer registries to identify incident cancers between 1996 and 2012. We analyzed four common NADM: anal, lung, prostate, and liver cancer. We calculated standardized incidence ratios (SIRs) and assessed the effect of time-updated CD4 and CD8 count, CD4/CD8 ratio, and HIV viral load (copies/ml) in Cox regression models. We lagged time-dependent variables for 12, 24, and 36 months and captured cumulative exposures using simple moving averages (SMA). In multivariable models, we also considered HIV transmission group, smoking, and chronic hepatitis B or C infection as potential predictors of NADM incidence.Results.Between 1996 and 2012, 563 HIV-infected individuals developed NADM, including 70 anal, 49 lung, 44 prostate, and 36 liver cancers. Compared with the general population, the SHCS exhibited higher rates of anal (SIR 76.1, 95% Confidence interval (CI) 60.2-96.2), lung (SIR 1.98, 1.50-2.62), and liver cancer (SIR 7.28, 5.25-10.1) but similar rates of prostate cancer (SIR 1.03, 0.76-1.38). Anal cancer was associated with low CD4 cell count, high CD8 cell count, men who have sex with men, and smoking. For lung cancer, the CD8 cell count was the only significant predictor identified among the immunological and virological factors. CD4 cell count, and chronic hepatitis B and C infection were predictive of liver cancer incidence. We found no evidence of any of the immunological factors being associated with prostate cancer.Conclusions:The importance of immunodeficiency (indexed by CD4 count) and immune senescence (indexed by CD8 count) differs across NADM. Immunodeficiency was an important risk factor for anal and liver cancer whereas immune senescence was associated with lung cancer and anal cancer.
Activity of manganese superoxide dismutase (MnSOD) as a predictor of radiation therapy outcome in patients with stage IIIB squamous cell carcinoma cervical cancer
Authors: Kusuma Fitriyadi , Sinaga Romi Saut Halomoan , Prijanti Ani Retno , Kekalih Aria , Sekarutami Sri Mulya 
Published: August 2019

BACKGROUND Radiation is a standard therapy for cervical cancer. Unfortunately, not all patients undergoing radiation achieve a complete response. Previous studies have shown that manganese superoxide dismutase (MnSOD) acts against free radicals generated by radiation in cancer cells thus predicting worse outcome in radiation therapy. This study was aimed to assess and evaluate whether MnSOD activity can be used as a predictor of radiation therapy responses in patients with stage IIIB squamous cell carcinoma (SCC).
METHODS A comparative cross-sectional study was conducted in the Gynecology Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta. The database from previous research was analyzed to identify positive and negative response samples. Measurement of MnSOD activity was done using spectrophotometry based on the McCord and Fridovich method using RanSOD® kit. The comparative data were obtained and then analyzed.
RESULTS Among 76 samples, 49 (61.8%) patients had positive responses and 27 (38.2%) had negative responses. It is shown in this study that higher MnSOD activity is related to worse radiotherapy outcome in stage IIIB cancer patients. The relative risk value of having a worse outcome with high MnSOD activity is 1.849 (1.075–3.178, 95% CI).
CONCLUSIONS Stage IIIB squamous cell carcinoma patients with high MnSOD activity are at higher risk of having a negative radiation therapy response compared with patients without high MnSOD activity.
GOVERNANÇA EM REDE E PARCERIAS PÚBLICO-PRIVADAS EM EDUCAÇÃO NO ESTADO DO RS
Authors: Cóssio Maria De Fátima , Scherer Susana Schneid 
Published: August 2019

Este artigo aborda dados parciais da pesquisa em desenvolvimento pelo NEPPE/UFPEL cujo objetivo é analisar os possíveis efeitos das parcerias público-privadas nos sistemas públicos de educação no Estado do Rio Grande do Sul (RS). Para tanto, aprofundaram-se os conceitos de Nova Gestão Pública (NGP) e de Governança, entendendo-os como centrais para a compreensão do cenário em que se instauram e proliferam as PPPs e as redes de políticas educacionais. A pesquisa utiliza uma abordagem qualitativa e a metodologia de etnografia de rede de Stephen Ball (2014) na coleta dos dados. Inicialmente realizou-se o mapeamento das instituições privadas que, de forma mais recorrente, atuam nos sistemas públicos. Desse levantamento, foram evidenciadas cinco instituições: Instituto Ayrton Senna (IAS), Instituto Natura, Sistema de Crédito Cooperativo (SICREDI), Associação dos Fumicultores do Brasil (AFUBRA) e Federação Nacional das Associações Atléticas do Banco do Brasil (FENABB). Após localizar os principais parceiros de cada ente, adaptaram-se às propriedades de rede, sugeridas por Tichy e colaboradores (1979), e citadas por Lopes e Baldi (2009), buscando contemplar a diversidade de esferas dessas relações e a natureza das ligações, observando questões de conteúdo, intensidade, reciprocidade, clareza, multiplexidade; e características estruturais como tamanho, densidade, clustering e centralidade. As análises das redes permitiram identificar as relações entre os parceiros e visualizar algumas aproximações com relação às propostas de cada um destes entes atuantes na educação do Estado do RS.