bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical device surveillance with electronic health records
Authors: Callahan Alison , Fries Jason A. , Ré Christopher , Huddleston James I. , Giori Nicholas J. , Delp Scott , Shah Nigam H. 
Published: September 2019

AbstractPost-market medical device surveillance is a challenge facing manufacturers, regulatory agencies, and health care providers. Electronic health records are valuable sources of real-world evidence for assessing device safety and tracking device-related patient outcomes over time. However, distilling this evidence remains challenging, as information is fractured across clinical notes and structured records. Modern machine learning methods for machine reading promise to unlock increasingly complex information from text, but face barriers due to their reliance on large and expensive hand-labeled training sets. To address these challenges, we developed and validated state-of-the-art deep learning methods that identify patient outcomes from clinical notes without requiring hand-labeled training data. Using hip replacements—one of the most common implantable devices—as a test case, our methods accurately extracted implant details and reports of complications and pain from electronic health records with up to 96.3% precision, 98.5% recall, and 97.4% F1, improved classification performance by 12.8–53.9% over rule-based methods, and detected over six times as many complication events compared to using structured data alone. Using these additional events to assess complication-free survivorship of different implant systems, we found significant variation between implants, including for risk of revision surgery, which could not be detected using coded data alone. Patients with revision surgeries had more hip pain mentions in the post-hip replacement, pre-revision period compared to patients with no evidence of revision surgery (mean hip pain mentions 4.97 vs. 3.23; t = 5.14; p < 0.001). Some implant models were associated with higher or lower rates of hip pain mentions. Our methods complement existing surveillance mechanisms by requiring orders of magnitude less hand-labeled training data, offering a scalable solution for national medical device surveillance using electronic health records.
Feasibility and utility of a clinician dashboard from wearable and mobile application Parkinson’s disease data
Authors: Elm Jordan J. , Daeschler Margaret , Bataille Lauren , Schneider Ruth , Amara Amy , Espay Alberto J. , Afek Michal , Admati Chen , Teklehaimanot Abeba , Simuni Tanya 
Published: September 2019

AbstractMobile and wearable device-captured data have the potential to inform Parkinson’s disease (PD) care. The objective of the Clinician Input Study was to assess the feasibility and clinical utility of data obtained using a mobile health technology from PD patients. In this observational, exploratory study, PD participants wore a smartwatch and used the Fox Wearable Companion mobile phone app to stream movement data and report symptom severity and medication intake for 6 months. Data were analyzed using the Intel® Pharma Analytics Platform. Clinicians reviewed participants’ data in a dashboard during in-office visits at 2 weeks, 1, 3, and 6 months. Clinicians provided feedback in focus groups leading to dashboard updates. Between June and August 2017, 51 PD patients were recruited at four US sites, and 39 (76%) completed the 6-month study. Patients streamed 83,432 h of movement data from their smartwatches (91% of expected). Reporting of symptoms and medication intake using the app was lower than expected, 44% and 60%, respectively, but did not differ according to baseline characteristics. Clinicians’ feedback resulted in ten updates to the dashboard during the study period. Clinicians reported that medications and patient reported outcomes were generally discernable in the dashboard and complementary to clinical assessments. Movement, symptoms, and medication intake data were feasibly translated from the app into a clinician dashboard but there was substantial attrition rate over 6 months. Further enhancements are needed to ensure long-term patient adherence to portable technologies and optimal digital data transfer to clinicians caring for PD patients.
Asphaltene oxide promotes a broad range of synthetic transformations
Authors: Jung Hyosic , Bielawski Christopher W. 
Published: September 2019

AbstractCarbocatalysts, which are catalytically-active materials derived from carbon-rich sources, are attractive alternatives to metal-based analogs. Graphene oxide is a prototypical example and has been successfully employed in a broad range of synthetic transformations. However, its use is accompanied by a number of practical and fundamental drawbacks. For example, graphene oxide undergoes explosive decomposition when subjected to elevated temperatures or microwaves. We found that asphaltene oxide, an oxidized collection of polycyclic aromatic hydrocarbons that are often discarded from petroleum refining processes, effectively overcomes the drawbacks of using graphene oxide in synthetic chemistry and constitutes a new class of carbocatalysts. Here we show that asphaltene oxide may be used to promote a broad range of transformations, including Claisen-Schmidt condensations, C–C cross-couplings, and Fischer indole syntheses, as well as chemical reactions which benefit from the use of microwave reactors.
Pflege managen
Authors: Schneider Melanie 
Published: September 2019

ZusammenfassungFür die praktische Ausbildung ergeben sich gravierende Veränderungen, die auch
das Pflegemanagement betreffen. Lesen Sie, wie Sie sich und Ihre
Mitarbeiter auf die Pflegefachfrauen und -männer von morgen vorbereiten
sollten.
The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine
Authors: Ahmadian Elham , Dizaj Solmaz Maleki , Eftekhari Aziz , Dalir Elaheh , Vahedi Parviz , Hasanzadeh Amir , Samiei Mohammad 
Published: September 2019

AbstractHyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.
Diffusion as a future perspective of agenda setting
Authors: Brosius Hans-Bernd , Haim Mario , Weimann Gabriel 
Published: September 2019

Abstract
The changing media environment has led to fragmentation of both media and audiences and thus to new flows of news items across channels and time. It has become challenging to clearly distinguish public and media agendas and their relationships. Our traditional way of counting single news items to determine an issue’s importance does not apply online. Articles are not scheduled into fixed publication cycles, they are moved, updated, or shared. Moreover, the variety of channels through which users encounter news loosens the connection between news items and their original source. We suggest “diffusion” as a concept to identify agenda-setting effects. News items are assigned different degrees of relevance by users clicking, liking, or sharing it. In turn, such relevance can affect others in assigning prominence to news items. The diffusion process results in a shared agenda which is constantly modified and updated by the entire community of online actors.
The role of language in scaffolding content & language integration in CLIL science classrooms
Authors: Tang Kok-Sing 
Published: September 2019

Abstract
This commentary to the special issue “Teaching, Learning and Scaffolding in CLIL Science Classrooms” synthesizes
the contributions from the authors by addressing two overarching questions. First, what is the role of language in mediating
science teaching and learning in a CLIL science classroom? Second, to what extent can content and language be integrated or
separated in CLIL instruction and assessment? In addressing the first question, I distil three major perspectives of how the
authors conceive the role of language as a scaffolding tool. These roles are: (a) providing the discursive means and structure for
classroom interaction to occur, (b) enabling students’ construction of knowledge through cognitive and/or linguistic processes,
and (c) providing the semantic relationships for science meaning-making. These three perspectives roughly correspond to the
discursive, cognitive-linguistic, and semiotic roles of language respectively. In addition, two other roles – epistemic and
affective, though not emphasized in this issue, are also discussed. In addressing the second question, I raise a dilemma
concerning the integration of content and language. While there are clear political and theoretical arguments calling for an
inseparable integration, there is also a common practice to separate content and language as distinct entities for various
pedagogical and analytical purposes. In revolving this conundrum, I suggest a way forward is to consider the differences in the
various roles of language (discursive/cognitive/linguistic vs. semiotic/epistemic/affective) or the levels of language involved
(lexicogrammar vs. text/genre).
Supporting students’ content learning in Biology through teachers’ use of classroom talk drawing on concept sketches
Authors: Ho Caroline , Kwai Yeok Wong June , Rappa Natasha Anne 
Published: September 2019

AbstractThis article examines teachers’ attempts to enhance students’ content learning in Biology through the use of talk centred on concept sketches. Of specific interest is how teachers provide scaffolding through purposeful classroom discourse (Lemke, 1990) with the use of talk moves (Chapin, O’Connor, & Anderson, 2013), drawing on concept sketches (Johnson & Reynolds, 2005) annotated by students. Informed by socioconstructivist (Vygotsky, 1978/86) perspectives and grounded in multimodal literacy (Kress & van Leeuwen, 2001) underpinnings, the study acknowledges the teacher’s role in productive classroom discussions to guide students’ thinking and facilitate meaning-making. Qualitative analysis of classroom discourse illustrates how teachers’ classroom talk can scaffold and address the gaps in students’ learning. Pedagogical implications are discussed.
The positioning of Japanese in a secondary CLIL science classroom in Australia
Authors: Turner Marianne 
Published: September 2019

AbstractIn Australia, content and language integrated learning (CLIL) is commonly implemented as a way to encourage innovation in language teaching. This paper explores how Japanese can also be used to innovate the teaching of content. Qualitative data are drawn from a Year 8 science Japanese CLIL classroom in a secondary school with an opt-in CLIL program. In the class, a monolingual (in English) science teacher was co-teaching with a Japanese language teacher. Findings from observations, after-class reflections, teacher and student interviews, a student survey and work samples revealed that students were highly engaged with the Japanese component of their science lessons. Kanji was further positioned as a way for students to deepen their understanding of scientific concepts. However, there also appeared to be a separation in the way both teachers and students spoke about Japanese language use and learning science. Implications of these findings are discussed in the paper.
Teacher language awareness and scaffolded interaction in CLIL science classrooms
Authors: Xu Daozhi , Harfitt Gary James 
Published: September 2019

AbstractTeacher language awareness (TLA) constitutes the teacher’s self-reflective knowledge about the operation of language systems in pedagogical practices. This study focuses on teachers’ understanding of learning of language and learning through language in Content and Language Integrated Learning (CLIL) contexts, exploring how teachers proceduralise their knowledge of language to facilitate science learning in Hong Kong. By analysing the reflective relationship between TLA and scaffolding strategies of two teachers (studentsn = 31; 32) during a set of lessons in a secondary school, this paper suggests that it is critical to re-orient the TLA focus from teachers to the act of learning and learners’ needs. This expanded conceptual framework of TLA sheds light on how to transform teachers’ implicit knowledge of language into explicit awareness of scaffolding in class. The TLA-filtered, scaffolded interactions can therefore promote the use of language not merely for pedagogical purposes but also as a cognitive learning tool.
Co-developing science literacy and foreign language literacy through “Concept + Language Mapping”
Authors: He Peichang , Lin Angel M. Y. 
Published: September 2019

AbstractDrawing onLemke’s (1990)“thematic patterns” theory, this research proposes a “Concept + Language Mapping” (CLM) approach and tried it out in an English Medium Instruction (EMI) biology classroom in Hong Kong. Lessons were observed and samples of student work were collected during the intervention with student/teacher interviews conducted afterwards. A quasi-experimental design was also adopted to estimate the impact of the CLM approach. The analysis indicated that CLM facilitated the development of both content and language knowledge.
Grammatical stance marking across registers
Authors: Larsson Tove 
Published: September 2019

AbstractThere are sets of grammatical stance markers that are morphologically and semantically related, but that differ with regard to their syntactic realization (e.g.,importantly,it is important thatandthe importance of). Little attention has, however, been paid to how these pattern across registers. This study examines eleven such sets across five registers in apprentice and expert production to investigate which register(s) the apprentice writers’ use is closest to and what that can tell us about their adherence to academic norms. The results show that there is a cline from thea priorimore formal registers to the less formal registers for the stance markers investigated. When the apprentice writers’ usage was mapped onto this cline, it became clear that their usage diverged slightly from that of the academic experts, thus indicating a lack of register awareness. Yet, very little evidence was found to support previous claims of the ‘spoken-like’ nature of learner writing.
What Is the Optimal Testing Strategy for Oropharyngeal Neisseria gonorrhoeae in Men Who Have Sex With Men? Comparing Selective Testing Versus Routine Universal Testing From Dutch Sexually Transmitted Infection Clinic Data (2008–2017)
Authors: van Liere Geneviève A F S , Dukers-Muijrers Nicole H T M , Kuizenga-Wessel Sophie , Götz Hannelore M , Hoebe Christian J P A 
Published: September 2019

Abstract

Background
Most oropharyngeal Neisseria gonorrhoeae infections are asymptomatic, and many infections remain undetected, creating a reservoir for ongoing transmission and potential drug resistance. It is unclear what the optimal testing policy is in men who have sex with men (MSM), as routine universal testing data are lacking.

Methods
Surveillance data from all Dutch sexually transmitted infection (STI) clinics between 2008 and 2017 were used (N = 271 242 consultations). Oropharyngeal testing policy was defined as routine universal testing when ≥85% of consultations included oropharyngeal testing or as selective testing (&lt;85% tested). Independent risk factors for oropharyngeal N. gonorrhoeae were assessed among MSM routinely universally screened using backward multivariable logistic regression analyses.

Results
Routine universal testing was performed in 90% (238 619/265 127) of consultations. Prevalence was higher using routine universal testing (5.5%; 95% CI, 5.4–5.6; 12 769/233 476) than with selective testing (4.7%; 95% CI, 4.4–5.0; 799/17 079; P &lt; .001). Proportions of oropharyngeal-only infections were 55% and 47%, respectively. Independent risk factors were age &lt;31 years (OR, 2.1; 95% CI, 1.9–2.3), age 31–43 years (OR, 1.7; 95% CI, 1.6–1.9, compared with &gt;43 years), being notified for any STI (OR, 2.0; 95% CI, 1.9–2.1), concurrent urogenital N. gonorrhoeae (OR, 2.4; 95% CI, 2.1–2.7), and concurrent anorectal N. gonorrhoeae (OR, 11.4; 95% CI, 10.6–12.3). When using any of the risk factors age, notified, or oral sex as testing indicators, 98.4% (81 022/82 332) of MSM would be tested, finding 99.5% (4814/4838) of infections.

Conclusions
Routine universal testing detected more oropharyngeal N. gonorrhoeae infections than selective testing, of which more than half would be oropharyngeal only. Using independent risk factors as testing indicator is not specific. Therefore, routine universal oropharyngeal testing in MSM is feasible and warranted, as currently advised in most guidelines.
Feasibility of a Habit Formation Intervention to Delay Frailty Progression Among Older African Americans: A Pilot Study
Authors: Fritz Heather , Hu Yi-Ling , Tarraf Wassim , Patel Pragnesh 
Published: September 2019

Abstract

Background and Objectives
Older African Americans are at high risk for becoming frail in later life. Interventions can reverse or delay frailty, yet African Americans have largely been excluded from such research. Many interventions are also time- and resource-intensive, and thus inaccessible to socially disadvantaged older African Americans. We evaluated the feasibility of a low-dose frailty prevention intervention integrated with primary care among 60 community-dwelling, prefrail older African Americans aged 55+ recruited from a primary care clinic.

Research Design and Methods
We conducted a 2-arm randomized control trial. Participants were assigned to a 4-session intervention (1 session per month), delivered by an occupational therapist, or enhanced usual care. Feasibility criteria were set a priori at 75% for participant retention (including attrition due to death/hospitalization), 80% for session engagement, 2 participants/week for mean participant accrual, and 90% for program satisfaction.

Results
Participants were 65% female with an average age of 76.6 years, 51.7% lived alone and 39.1% reported &lt;$10,000 in yearly income. Feasibility metrics were met. The study recruited, a mean of, 2.5 participants per week and retained 75% of participants who attended 95% of scheduled sessions. The mean satisfaction score was 29.75 (range = 0–32; SD .25). Changes in physical activity and dietary habit formation as well as changes in secondary outcomes were largely in the expected direction.

Discussion and Implications
The intervention was feasible to deliver. Qualitative findings from exit interviews suggested changes to the program dose, structure, and content that could improve it for future use.
The Impostor Syndrome from Luxury Consumption
Authors: Goor Dafna , Ordabayeva Nailya , Keinan Anat , Crener Sandrine 
Published: September 2019

AbstractThe present research proposes that luxury consumption can be a double-edged sword: while luxury consumption yields status benefits, it can also make consumers feel inauthentic, producing what we call the impostor syndrome from luxury consumption. As a result, paradoxically, luxury consumption may backfire and lead consumers to behave less confidently due to their undermined feelings of self-authenticity. Feelings of inauthenticity from luxury consumption may arise because consumers perceive luxury as an undue privilege. These feelings are less pronounced among consumers with high levels of chronic psychological entitlement, and they are reduced when consumers’ sense of entitlement is temporarily boosted. The effects are robust across studies conducted in the lab and in field settings such as the Metropolitan Opera, Martha’s Vineyard, a luxury shopping center, and the Upper East Side in New York, featuring relevant participant populations including luxury target segments and consumption contexts including consumers’ reflections on their actual past luxury purchases.
Molecular Characterization of the Danish Prion Diseases Cohort With Special Emphasis on Rare and Unique Cases
Authors: Areškevičiūtė Aušrinė , Broholm Helle , Melchior Linea C , Bartoletti-Stella Anna , Parchi Piero , Capellari Sabina , Scheie David , Lund Eva L 
Published: September 2019

AbstractThe purpose of this study was to perform an updated reclassification of all definite prion disease cases with available fresh-frozen samples referred to the Danish Reference Center over the past 40 years, putting a special emphasis on the molecular characterization of novel disease subtypes. Investigation of the Danish prion diseases cohort revealed rare sporadic Creutzfeldt-Jakob disease cases with mixed subtypes and subtypes with previously uncharacterized white matter plaques, a new case of sporadic fatal insomnia, and 3 novel mutations, including 2 large octapeptide repeat insertions, and a point mutation in the prion protein gene. The evaluation of methionine and valine distribution at codon 129 among the prion disease patients in the cohort revealed the increased prevalence of methionine homozygotes compared to the general population. This observation was in line with the prevalence reported in other Caucasian prion disease cohort studies. Reclassification of the old prion diseases cohort revealed unique cases, the molecular characterization of which improves prion diseases classification, diagnostic accuracy, genetic counseling of affected families, and the understanding of disease biology.
Opening the black box of PSF network internationalization: An exploration of law firm networks
Authors: Salvoldi Rany , Brock David M 
Published: September 2019

AbstractThis article advances our understanding of network internationalization by professional service firms. We address gaps in the literature concerning the various kinds of networks; their role in international strategies, including learning, and knowledge transfer; and their structural and governance mechanisms. Concentrating on the network dependency of 177 European law firms, we analyse and summarize their structural and governance tendencies. Then we develop a typology of seven international peer networks. The seven types identified are: ‘Loose’, a network of disconnected actors, where exchange is mostly limited to referrals; ‘Constricted’, referral-based networks aimed at optimizing exchange flows and cooperation; ‘Focused’, networks aimed at a specific sector or specialty; ‘Friends’, informal, non-exclusive networks; ‘Exclusives’, formal alliances or cooperative relations; ‘Monogamous’, well-established, broad, longstanding, and close relationships; and ‘Isolated’, project-related alliances of limited duration. We conclude with a discussion that considers this typology in light of possible intangible outcomes of membership and proposes how this might be extended in future research.