bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Septal Deviation on Recurrent Chronic Rhinosinusitis after Primary Surgery: A Matched Case‐Control Study
Authors: Fu Terence , Lee Daniel , Yip Jonathan , Jamal Alisha , Lee John M. 
Published: November 2018

ObjectiveTo evaluate the impact of untreated deviated nasal septum (DNS) on recalcitrant chronic rhinosinusitis (CRS) among patients undergoing revision endoscopic sinus surgery (ESS).Study DesignCase‐control study.SettingTertiary academic center.Subjects and MethodsWe performed a retrospective review of 489 patients undergoing revision ESS for CRS at a tertiary academic center. Patients undergoing septoplasty were matched to nonseptoplasty controls based on age and sex. Preoperative Lund‐Mackay score (LMS) was compared between cohorts. Linear regression was used to identify predictors of LMS and ostiomeatal complex (OMC) obstruction.ResultsThirty‐six matched pairs (72 patients) were selected for analysis: 36 undergoing septoplasty and revision ESS and 36 undergoing revision ESS alone. Compared with nonseptoplasty controls, the septoplasty group had a significantly higher average LMS (17.8 vs 14.6, P =. 02) and a greater rate of OMC obstruction (89% vs 61%, P <. 01). The septoplasty group also had significantly higher opacification scores in the maxillary (1.5 vs 1.2, P =. 03) and posterior ethmoid (1.8 vs 1.4, P =. 02) sinuses. On multivariable analysis, DNS was an independent predictor of LMS (P =. 02) and OMC obstruction (P <. 01).ConclusionUntreated DNS is associated with radiographic markers of CRS severity among patients undergoing revision ESS and may contribute to the multifactorial pathogenesis of persistent CRS.
Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus
Authors: Srikumar Bettadapura N , Naidu Pattipati S , Kalidindi Narasimharaju , Paschapur Mahesh , Adepu Bharath , Subramani Siva , Nagar Jignesh , Srivastava Ratika , Sreedhara Muppana V , Prasad Durga Shiva , Das Manish Lal , Louis Justin V , Kuchibhotla Vijaya K , Dudhgaonkar Shailesh , Pieschl Rick L , Li Yu-Wen , Bristow Linda J , Ramarao Manjunath , Vikramadithyan Reeba K 
Published: November 2018

Background: A significant proportion of patients suffering from major depression fail to remit following treatment and develop treatment-resistant depression. Developing novel treatments requires animal models with good predictive validity. MRL/lpr mice, an established model of systemic lupus erythematosus, show depression–like behavior. Aims: We evaluated responses to classical antidepressants, and associated immunological and biochemical changes in MRL/lpr mice. Methods and results: MRL/lpr mice showed increased immobility in the forced swim test, decreased wheel running and sucrose preference when compared with the controls, MRL/MpJ mice. In MRL/lpr mice, acute fluoxetine (30 mg/kg, intraperitoneally (i.p.)), imipramine (10 mg/kg, i.p.) or duloxetine (10 mg/kg, i.p.) did not decrease the immobility time in the Forced Swim Test. Interestingly, acute administration of combinations of olanzapine (0.03 mg/kg, subcutaneously)+fluoxetine (30 mg/kg, i.p.) or bupropion (10 mg/kg, i.p.)+fluoxetine (30 mg/kg, i.p.) retained efficacy. A single dose of ketamine but not three weeks of imipramine (10 mg/kg, i.p.) or escitalopram (5 mg/kg, i.p.) treatment in MRL/lpr mice restored sucrose preference. Further, we evaluated inflammatory, immune-mediated and neuronal mechanisms. In MRL/lpr mice, there was an increase in autoantibodies’ titers, [3H]PK11195 binding and immune complex deposition. There was a significant infiltration of the brain by macrophages, neutrophils and T-lymphocytes. p11 mRNA expression was decreased in the prefrontal cortex. Further, there was an increase in the 5-HT2aR expression, plasma corticosterone and indoleamine 2,3-dioxygenase activity. Conclusion: In summary, the MRL/lpr mice could be a useful model for Treatment Resistant Depression associated with immune dysfunction with potential to expedite antidepressant drug discovery.
Alternations of interhemispheric functional connectivity in corneal ulcer patients using voxel-mirrored homotopic connectivity: a resting state fMRI study
Authors: Shi Wen-Qing , Liu Jia-Xiang , Yuan Qing , Ye Lei , Su Ting , Jiang Nan , Lin Qi , Min You-Lan , Li Biao , Zhu Pei-Wen , Xu Xiao-Wei , Shao Yi 
Published: November 2018

Background Corneal ulcer (CU) is the second ocular disease leading to blindness. Millions of people around the world suffer from CU. However, the relationship between CU and altered functional connectivity in the brain is still unknown. Purpose The aim of the present study was to investigate the alterations of the brain interhemispheric functional connectivity (FC) in patients with CU using the voxel-mirrored homotopic connectivity (VMHC) method and their relationship with clinical manifestations. Material and Methods The present study involved 24 patients with CU (12 men, 12 women) and 24 healthy controls (HCs) with their age, sex, and weight closely matched. Independent sample t-test, VMHC method, and Pearson’s correlation analysis were applied. Receiver operating characteristic (ROC) curve analysis was used to estimate the effect in distinguishing CU patients from HCs. Results The CU patients showed decreased VMHC values in bilateral lingual/calcarine, precentral/postcentral gyrus, and medial frontal gyrus compared with HCs. There were positive correlations between Visual Analogue Score (VAS) and VMHC values of bilateral media frontal gyrus ( r = 0.654, p = 0.001), the best-corrected VA of the affected eye and VMHC values of the bilateral lingual/calcarine region ( r = 0.960, p < 0.001). ROC curve also showed high diagnostic values in those regions. Conclusion Our study was the first to explore FC changes in CU patients’ brains using VMHC methods. We demonstrated that ocular pain of CU patients had a close relationship with altered VMHC values. Decreased VMHC values in the brain of CU patients may be useful markers to reflect the condition of progress in patients with CU.
Recurrence of Patellar Instability in Adolescents Undergoing Surgery for Osteochondral Defects Without Concomitant Ligament Reconstruction
Authors: Pedowitz Jason M. , Edmonds Eric W. , Chambers Henry G. , Dennis M. Morgan , Bastrom Tracey , Pennock Andrew T. 
Published: November 2018

Background: First-time patellar dislocation with an associated chondral or osteochondral loose body is typically treated operatively to address the loose fragment. The incidence of recurrent instability in this patient population if the medial patellofemoral ligament (MPFL) is not reconstructed is unknown. Purpose: To determine the recurrent instability rate in patients undergoing surgery for patellar instability with chondral or osteochondral loose bodies, as well as to identify and stratify risk factors for recurrent instability. Study Design: Case series; Level of evidence, 4. Methods: This was a retrospective analysis of adolescent patients treated operatively for acute patellar dislocation with associated chondral or osteochondral loose bodies between 2010 and 2016 at a single pediatric level I trauma center with minimum 2-year follow-up. Potential demographic, injury-related, radiographic, and surgical risk factors were recorded. The primary outcome variable was recurrent subluxation and/or dislocation. Secondary outcome variables included need for additional procedures, Kujala score, Single Assessment Numerical Evaluation (SANE) score, and patient satisfaction. Results: Forty-one patients were included. In total, 61% experienced recurrent instability at a mean follow-up of 4.1 years and 39% required subsequent MPFL reconstruction. Tibial tubercle-trochlear groove (TT-TG) distance greater than 15 mm was a risk factor for recurrent instability ( P = .03). Patients with TT-TG distance greater than 15 mm and greater than 20 mm had recurrent instability rates of 75% and 86%, respectively. MPFL repair did not reduce the rate of recurrent instability ( P = .87). Recurrent instability was associated with significantly worse mean Kujala (93.9 vs 83.0; P = .01), SANE (88.9 vs 73.1; P = .01), and patient satisfaction scores (9.4 vs 7.3; P = .002). Conclusion: If the MPFL is not reconstructed during index loose body treatment, children have a 61% recurrent instability rate. Patients with TT-TG distance greater than 15 mm, and particularly greater than 20 mm, are at highest risk for recurrent instability.
Problems in International Protection of Intellectual Property Rights
Authors: Jain Subhash C. 
Published: November 2018

Intellectual property rights are policies that assign and protect the rights to earn income from innovative and creative activity. These rights provide legal authority to control the dissemination and commercialization of new information and ideas and to enforce sanctions against their unauthorized use. Intellectual property rights play a critical role in global economic growth and development because they affect the profitability of industrial research and the rewards to creative activity. At the same time, intellectual property rights are controversial because their stronger international protection may come at the expense of higher prices and reduced availability of products, particularly in developing countries. Obviously, developing countries prefer a low level of protection. Traditionally, intellectual property rights were of concern only to a few lawyers specializing in the field. But the enormous expansion in world trade in the 1980s elevated intellectual property rights to new prominence in international trade policy. At the same time, new and emerging technologies have made traditional protection of intellectual property rights inadequate. For these reasons, the topic of international protection of intellectual property rights should be an important subject of concern among international business and marketing scholars. This article provides an overview of intellectual property rights and their international protection. The conflict between the industrialized and developing countries on the level of protection is highlighted. Issues and controversies that affect the field today are examined. Finally, ideas are advanced for further research on the subject.
Marketing's Integration with R&D and Manufacturing: A Cross-Regional Analysis
Authors: Kahn Kenneth B. , McDonough Edward F. 
Published: November 2018

With the emergence of global teams, marketing managers are not only confronted with interdepartmental issues, but cultural issues as well. As yet, most literature has focused on interdepartmental integration within a single-country company, indicating that integration via interaction and collaboration improves performance success. The question is whether this framework holds in a global context between marketing, R&D, and manufacturing. A research study of 500 marketing, manufacturing, and R&D managers was undertaken to address this question and determine the influences that interaction and collaboration may have on performance across U.S., European, and Far Eastern companies. Research further compared the levels of interaction and collaboration used by different departments across these three regions. Findings suggest that a global framework may exist, which highlights collaboration and, to a lesser degree, interaction as factors in performance success. Findings also suggest that there may be certain culturally specific approaches for managing interdepartmental relationships.
A pilot study on the impact of a pottery workshop on the well-being of people with dementia
Authors: Pérez-Sáez Enrique , Cabrero-Montes Elena M , Llorente-Cano María , González-Ingelmo Elena 
Published: November 2018

Objective This study seeks to assess the impact of a pottery workshop as a creative arts programme and discover the extent to which people with dementia taking part in an artistic and creative activity engage with it, experience a feeling of well-being, and improve their mood state. In addition, the study will seek to answer the question of whether taking part in a programme of creative activities improves the self-esteem of people with dementia. Method The research used an uncontrolled, repeated measures design. Thirty users of the National Reference Centre for Alzheimer’s and Dementia care in Salamanca (Spain) in a moderate to advanced stage of dementia (Global Deterioration Scale 4, 5, or 6) were divided into five intervention groups that received ten 45-minute sessions in which they were helped by facilitators to make different ceramic pieces. The participants were assessed before and after the intervention with a self-esteem scale, and they rated their mood before and after the sessions on a graphic scale. During the art sessions, two observers recorded the presence of multiple indicators of well-being. Results The intervention was found to have a significant impact on mood and self-esteem that was independent of the participants’ Global Deterioration Scale. Regarding the tool used to observe well-being, the participants scored highly in the domains of sustained attention, pleasure, self-esteem, and normalcy, with low scores in negative affect and sadness. Conclusions Pottery may be a highly suitable activity for people with dementia, as they may enjoy both the activity and the creative process, with it triggering a positive mood during the sessions, providing psychological well-being and reinforcing their self-esteem.
Guideposts for Inserting Intercuneiform Joint Arthrodesis Screws: Analysis Using Multiplanar Reconstructed Computed Tomography
Authors: Maenohara Yuji , Matsumoto Takumi , Chang Song Ho , Hirose Jun , Tanaka Sakae 
Published: November 2018

Intercuneiform arthrodesis is often required for various midfoot pathologies; however, intercuneiform screw insertion is not easy due to the complicated anatomical structure of cuneiforms. This study aimed to determine the advisable screw entry point and direction using intraoperatively detectable landmarks. The computed tomography (CT) scan data of feet were reformatted using OsiriX software multiplanar reconstruction. First, based on the data of 10 CT scans of normal feet, we determined the advisable screw entry point at the upper one-third in the dorsoplantar direction and center in the anteroposterior direction on the medial aspect of the medial cuneiform and insertion direction toward the outermost point of the base of the fifth metatarsal in the axial plane and parallel to the plantar surface in the coronal plane. Second, we examined the accuracy of these newly designed guideposts in the simulation using other CT scan data of the other 27 normal feet and 12 flat feet. The simulated screw trajectory penetrated the mid three-fifths of all three cuneiforms in 97% of the normal feet and 92% of the flat feet with no cases of cortical wall violation. Levels of Evidence: Level V: Expert opinion
Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis
Authors: Jin Andy J. , Chin Christopher J. 
Published: November 2018

Background Complementary and alternative medicine (CAM) is frequently used in the treatment of chronic rhinosinusitis (CRS) in developed countries. With a plethora of CAM therapies available, their effectiveness and safety are poorly understood in the context of CRS. Objectives This article aims to critically appraise the evidence for CAM use in CRS through a systematic review of current literature that investigate the effects of CAM on symptoms and clinical status of adults with CRS. Study Design Systematic review and qualitative analysis. Review Methods A comprehensive systematic review of the literature was conducted by the authors using 5 databases from inception to July 2017: CINAHL, Cochrane, Embase, PubMed, and SCOPUS. Inclusive medical subject headings and keywords consisted of, but were not limited to, sinusitis and complementary therapies, naturopathy, or traditional Chinese medicine. PRISMA guideline was followed. Using templates by Cochrane Public Health Group and Newcastle-Ottawa Scale, each author extracted data, assessed bias, and computed minimal clinically important difference. Any conflicts were resolved through discussion. Results In total, 7 of 7141 articles from 1995 to 2016 were included. Three randomized controlled trials and 4 observational studies were organized into 4 categories of CAM: naturopathy, Chinese medicine, homeopathy, and others. Limited evidence supported the use of Pimpinella anisum and crenotherapy for CRS. Data available on Chinese medicine, homeopathy, and liposomal therapy in CRS were inconclusive due to inherent flaws in the studies. Conclusion Overall, there is very limited evidence to support the use of CAM in the treatment of CRS. No significant adverse effects have been found. Given its widespread use, more rigorous data from high-quality research are needed before it can be routinely recommended.
Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community
Authors: Gohar Aisha , Kievit Rogier F , Valstar Gideon B , Hoes Arno W , Van Riet Evelien E , van Mourik Yvonne , Bertens Loes C , Boonman-Winter Leandra J , Bots Michiel L , Den Ruijter Hester M , Rutten Frans H 
Published: November 2018

Abstract

Background
The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-cause mortality. Therefore we aimed to develop sex-specific diagnostic models to enable the early identification of men and women at high-risk of left ventricular diastolic dysfunction with or without symptoms of heart failure who require more aggressive preventative strategies.

Design
Individual patient data from four primary care heart failure-screening studies were analysed (1371 participants, excluding patients classified as heart failure and left ventricular ejection fraction &lt;50%).

Methods
Eleven candidate predictors were entered into logistic regression models to be associated with the presence of left ventricular diastolic dysfunction/heart failure with preserved ejection fraction in men and women separately. Internal-external cross-validation was performed to develop and validate the models.

Results
Increased age and β-blocker therapy remained as predictors in both the models for men and women. The model for men additionally consisted of increased body mass index, moderate to severe shortness of breath, increased pulse pressure and history of ischaemic heart disease. The models performed moderately and similarly well in men (c-statistics range 0.60–0.75) and women (c-statistics range 0.51–0.76) and the performance improved significantly following the addition of N-terminal pro b-type natriuretic peptide (c-statistics range 0.61–0.80 in women and 0.68–0.80 in men).

Conclusions
We provide an easy-to-use screening tool for use in the community, which can improve the early detection of left ventricular diastolic dysfunction/heart failure with preserved ejection fraction in high-risk men and women and optimise tailoring of preventive interventions.
Optimizing the use of a nutrition screening tool for oncology patients.
Authors: Parrales Carol , Alencar Maritza Cardena , MacIntyre Jessica , Trivedi Chinny , Araujo Patricia 
Published: November 2018

101 Background: Oncology infusion centers play a crucial role in detection of malnutrition. In one month, the Sylvester Comprehensive Cancer Center chemotherapy infusion center in Miami (SCCC CTU) treats over 400 oncology patients. Research shows that 40-80% of patients with a cancer diagnosis are malnourished (Isenring et al., 2006). In April, 1.89% of patients seen at the Miami CTU were referred to an oncology nutritionist. The goal was to increase the percentage of patients referred by 2% by June through adequate screening and referral. Methods: SCCC Miami CTU nursing staff’s knowledge on the use of the Malnutrition Screening Tool (MST) and the referral process were assessed through a survey. The survey also functioned as an educational instrument. Additionally, one-on-one discussions about the referral process were conducted with the SCCC CTU nurse practitioners. Results: The survey was available to CTU RNs with a 35% completion rate. Results portrayed that 82.35% were aware of the MST screening tool; however, 88.25% were unaware of the appropriate code to refer patients to nutritionist. Therefore, if nutritional consults were placed, it was unlikely that the nutritionist would receive the request. Identified obstacles included having to call a provider to initiate a consult, lack of time for proper assessment and the availability of a nutritionist. Conclusions: Although results did not yield a significant increase of referrals through the use of the appropriate code, there was a 1.22% increase on the overall referrals placed. Lack of training and knowledge on the MST, improper use of the referral code, and the intricacy of the workflow, were contributing factors to the inadequacy in screening and referral process. Participation of all staff in education initiatives and interventions should be a vital component in improving quality care of oncology patients. [Table: see text]
Establishing a denominator for palliative care quality metrics for patients with advanced cancer.
Authors: Anand Sidharth , Glaspy John A. , Roh Lily , Khandelwal Vilay , Wenger Neil , Ritchie Christine , Walling Anne Margaret 
Published: November 2018

104 Background: Measurement and feedback of palliative care quality metrics for patients with advanced cancer is an important aspect of supporting a shared mental model for the early integration of palliative care within the oncology clinic. Accurately identifying the subset of advanced cancer patients within a population of cancer patients is critical to the development of quality improvement activities; however, there is not a methodology of identifying these patients in real time. Methods: We evaluated two main approaches to identifying patients with advanced cancer among active cancer patients defined as patients who were seen by an oncologist at least twice in the last 6 months and who had received chemotherapy or radiation at least once in the last two years. These approaches included: 1) Pattern matching of words indicating advanced cancer (e.g. metastatic, advanced) in oncology notes, radiology imaging and problem lists and 2) ICD-10 codes. To determine the final set of ICD-10 codes for the second approach, we used a conceptual model of the meaning of advanced cancer (evidence of distant metastasis and/or poor prognostic cancer with > 50% mortality rate at 5 years) and iterative chart review. In order to test our final definitions, we randomly selected 588 charts of patients with active cancer who see one of 64 oncologists in our health system. These charts were abstracted by an oncologist to establish a gold standard for advanced cancer. We evaluated the sensitivity and specificity of our approaches to identify advanced cancer patients compared to this gold standard. Results: We found that the methods used to identify patients using pattern matching had a specificity of 76% and a sensitivity of 80%. Using our final ICD-10 algorithm we achieved a specificity of 93% and a sensitivity of 68%. We improved our sensitivity to 74% while maintaining our specificity at 92% when we excluded oncologists who predominantly see hematological malignancies. Conclusions: We achieved high specificity and reasonable sensitivity for an advanced cancer quality metric denominator using an ICD-10 algorithm within an academic oncology practice. This will help inform quality improvement efforts locally and beyond.