bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia
Authors: Bin-Jaliah I , Sakr HF 
Published: March 2018

The aim of this study was to investigate the effect of melatonin on oxidative stress and senescence marker protein-30 (SMP30) as well as osteopontin (OPN) expression in the hippocampus of rats subjected to vascular dementia (VD). A total of 72 male rats were divided into six groups (n = 12 each) as follows: (i) untreated control (CON), (ii) sham-operated group, (iii) sham-operated + melatonin, (iv) rats exposed to VD induced by permanent bilateral occlusion of the common carotid arteries (BCCAO) leading to chronic cerebral hypoperfusion, (v) rats exposed to VD + melatonin, and (vi) rats exposed to VD + donepezil (DON). At the end of experiment, the hippocampal levels of acetylcholine (ACh), norepinephrine (NE), and dopamine (Dop) were measured. Expression of OPN was determined using immunohistochemistry, and SMP30 expression was determined using real-time PCR in the hippocampus. Hippocampal thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) were evaluated. The BCCAO group showed significantly decreased TAC (p < 0.05) and significantly increased in TBARS levels compared with the CON group. In addition, BCCAO significantly decreased (p < 0.05) the expression of both OPN and SMP30 and the levels of ACh, NE, and Dop in the hippocampus compared with CON treatment. Treatment with melatonin significantly increased OPN and SMP30 expression and ACh, NE, and Dop levels in the hippocampus with amelioration of the oxidative stress compared with BCCAO rats. Melatonin might produce a neuroprotective effect through its antioxidant action and by increasing the expression of SMP30 and OPN that is not comparable with that of DON.
Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide
Authors: Canbolat S , Nurullahoglu Atalik KE 
Published: March 2018

Moderate hypothermia (25–31 °C) may have a significant influence on vascular tone. At present, very little is known about the role of endothelial nitric oxide on the hypothermia-induced responses. In this study, we investigated the effect of hypothermia (to 28 °C) on the vasodilatation induced by verapamil, a phenylalkylamine calcium channel blocker (10−9–3 × 10−4 M) and dihydropyridines, amlodipine (10−9–3 × 10−4 M), and benidipine (10−9–10−3 M) on 5-hydroxytryptamine (5-HT or serotonin) precontracted calf cardiac veins. Furthermore, the role of nitric oxide in the hypothermia-induced responses was analyzed. Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 15 ml of Krebs–Henseleit solution, maintained at 37 °C, and continuously gassed with 95% O2–5% CO2. After a resting period, verapamil, amlodipine, and benidipine were applied cumulatively on serotonin (10−6 M) precontracted calf cardiac vein rings and induced concentration-dependent relaxations. In another part of the study, the medium temperature was decreased to 28 °C after the preparations were contracted with 5-HT, then cumulative concentrations of verapamil, amlodipine, or benidipine were added. During hypothermia, the pIC50 value, but not the maximal response, to all blockers were significantly higher than at 37 °C. Hypothermia in the presence of NG-nitro-l-arginine methyl ester (L-NAME, 10−4 M) decreased the pIC50 and Emax values to verapamil, amlodipine, and benidipine. Only one blocker was tested in each preparation. These results suggest that nitric oxide may play a role in the hypothermia-induced changes in vasodilation caused by verapamil, amlodipine, and benidipine in calf cardiac vein, but further research is needed to explain the complete mechanism.
Effect of iloprost on contractile impairment and mitochondrial degeneration in ischemia-reperfusion of skeletal muscle
Authors: Bagis Z , Ozeren M , Buyukakilli B , Balli E , Yaman S , Yetkin D , Ovla D 
Published: March 2018

Purpose
Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model.

Main Methods
Forty Wistar albino rats were randomly divided into a control group and four experimental groups. Experimental groups were either subjected to 2 h of lower extremity ischemia followed by a 4-h reperfusion period or to 4 h of ischemia followed by an 8-h reperfusion period. Except for the animals in the control group, all animals received IL (1 ng/kg/min) or saline (1 ml/kg) by intraperitoneal infusion for 10 min immediately before reperfusion. At the end of the recording of skeletal muscle electrical activity and contractility, all rats were sacrificed by decapitation and muscle samples of lower extremity were immediately harvested for histopathologic analyses.

Results
After ischemia-reperfusion, a breakdown in the force–frequency curves of extensor digitorum longus muscle was observed, showing the diminished muscle contractility. However, IL significantly improved muscle contractility following injury induced by 2 h of ischemia followed by a 4-h reperfusion period. In addition, IL partially ameliorated mitochondrial degeneration in the muscle cells of ischemia groups.

Conclusion
This study indicates that immediate IL therapy repairs muscle damage especially after 2 h of ischemia and 4 h of reperfusion and therefore that IL improves contractile function.
Effect of Cytochrome P450 (CYP) 2D6 Genetic Polymorphism on the Inhibitory Action of Antidepressants on CYP2D6-Mediated Dopamine Formation from p-Tyramine
Authors: Niwa Toshiro , Yanai Mayumi , Matsumoto Maya , Shizuku Marina 
Published: March 2018

PURPOSE: The inhibitory effects of antidepressants, such as imipramine, desipramine, and fluvoxamine, on dopamine formation from p-tyramine catalyzed by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with those on dopamine formation catalyzed by CYP2D6.1 (wild type), to investigate the effect of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain. METHODS: Inhibition constants (Ki) of the antidepressants toward dopamine formation catalyzed by CYP2D6.1, CYP2D6.2, and CYP2D6.10, which were expressed in recombinant Escherichia coli, were compared. RESULTS: Imipramine and desipramine competitively or non-competitively inhibited dopamine formation mediated by CYP2D6.1, CYP2D6.2, and CYP2D6.10 with Ki values of 3.9–4.9, 5.9–9.6, and 26.7–37.5 µM, respectively. The maximal velocity (Vmax) values for dopamine formation by all CYP2D6 variants gradually increased with increasing fluvoxamine concentrations up to 40–100 µM, indicating that fluvoxamine stimulated dopamine formation. CONCLUSIONS: These results suggest that the inhibition/stimulation of CYP2D6-mediated dopamine formation by these antidepressants would be affected by CYP2D6 polymorphism in the brain. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
PERCEPTION OF ACADEMIC STAFF OVER THEIR CAREER DUE TO TECHNOLOGY IMPLEMENTATION AT SOHAR UNIVERSITY
Authors: AL-Shibli Sulaiman Said , Abu Shakra Ahmad , Khan Dr. M. Firdouse Rahman 
Published: March 2018

Purpose: The objectives of the study are to analyze ways through which technology introduced in Sohar University is helping the lectures teaching in the University and improves their research activities and to analyze the methods of administrative works of lectures in the University.
Design/methodology/approach: To carry out this research study, 133 samples were collected from academic staff working in all the faculties of Sohar University using a questionnaire. The questionnaire was containing the personal details, teaching, research and administration related factors. The data obtained was analyzed, and interpreted to obtain the result.
Main Findings: The study reveals that the academic staff feels the technology implementation has improved the teaching pattern and standards of the university and hence their teaching style also has changed. It is also proven that the academic staff feels the technology implementation has helped to improve their research career. It is shown that the academic staff feels the technology implementation has helped to reduce their administrative work.
Research limitations/Implications: It was reported that the technology implementation would be successful only when adequate training is given beforehand and most time is wasted for rectifying the technical bugs arising due to technological implementation.
Social implications: The study suggests that technology implementation is successful only if technical staff regularly maintains computers. They also suggested that there is a need for software skills training though it is time-consuming.
Originality/Value: Only a very few have examined the perception of the academic staff of all the faculties at University level in Oman, and it is a first-hand study of its kind, and the results will be useful to IT departments.
THE IMPLEMENTATION OF ISLAMIC SPIRITUALITY AND ISLAMIC SOCIAL RESPONSIBILITY ON ISLAMIC BANKING EMPLOYEES, ITS IMPLICATION TOWARDS WORKPLACE DEVIANCE
Authors: Siswanto Siswanto 
Published: March 2018

<p>This study aims to analyze the effects of Islamic spirituality and Islamic social responsibility on workplace deviance. Series of data analysis techniques have been projected to achieve the goal oriented. However, the techniques include descriptive statistical analysis through cross tabulation, comparative test and Partial Least Square (PLS) analysis. The results indicate that: 1) the characteristic of employee age determine the difference of Islamic spirituality implementation, 2) the difference of employee age determines the difference of Islamic social responsibility implementation, 3) the differences of biographical characteristics of Islamic banking employees covering gender differences, marital status, and age differences do not determine implementation of workplace deviance, 4) Implementation of Islamic piety concept which includes Islamic spirituality or personal piety, and social responsibility or social piety affect deviant behavior in the workplace. Social piety can reduce deviant behavior in the workplace. While personal piety is not able to reduce deviant behavior in the workplace.</p><p>Keywords: Islamic spirituality, Islamic social responsibility, Workplace deviance</p>
ANALYZING THE EFFECT OF TRUST AND PERCEIVED VALUE ON PURCHASE INTENTION (Case Study of Shopee)
Authors: Rafsandjani Rieza Firdian 
Published: March 2018

<p>The progress of marketing is accelerating, nowadays people do not have to waste their time walking to the store to buy things. They just need to browse the internet and search for what they want and get it in no time. With this convenience and speed, online shopping interest is increasing. When customers intend to purchase products from the internet, they consider values and perceived beliefs. The main purpose of this study is to analyze the influence of the perception of values and beliefs on purchasing intentions in Shopee. Data were collected from 50 respondents and multiple regression analysis was used to test the relationship between variables. Based on the indicators described on the perception of value that is the value of experimental, functional value, market value and on the belief that is the ability, virtue, integrity then they have a significant partial influence on the purchase intention. The results can be maintained by giving customers the best value and earning their trust to maintain their purchase intentions.</p><p> </p>
THE INFLUENCE OF ISLAMIC ETHICAL RETURN, INVESTMENT AND FIRM VALUE
Authors: Febri, RS. Wahyu , Sagena Basir 
Published: March 2018

<p>An interest of investors in investing in the stock market is to get a rate of return as an element of revenue. Given this background, this study was to determine the influence of ethical Islamic return on investment and the value of the company, as well as the effect of the investment on firm value. The research was conducted on companies listed in the Jakarta Islamic Index for the period 2012-2015. The results showed an increase in income of non-kosher will lower interest of investors to invest, increase the amount of revenue non-kosher will lower the value of the company, an increase in the deviation of investment according to Islamic principles have a negative significant effect to company value, and increasing the amount of income halal through investments based on the principle of sharia will enhance shareholder value.</p><p class="Keywords"><strong> </strong></p>
İSLAM DÜŞÜNÜRÜ BELHİ’NİN (849-934) RUH SAĞLIĞINA YÖNELİK GÖRÜŞLERİNİN MODERN PSİKOLOJİ DOĞRULTUSUNDA DEĞERLENDİRİLMESİ
Authors: GÜRSU Orhan 
Published: March 2018

Studies have been
done in both traditional and modern sources regarding physical and mental
health of human beings because it has long been a field of interest of
humanity. Especially in today's rapid life cycle because of modern life, an
increase in psychological problems, anomie, the quest for meaning have
highlighted the importance of physical and mental health. Today at the point we
have reached, we can easily say that there is significant knowledge about
physical and mental health in both theoretical and practical areas. The topic
is also an important element in the area of Islamic culture of research.
However, it is difficult to say that there is enough information on this issue
because Islamic traditional sources are not being focused on enough and what
Islamic tradition says about the topic is mostly overlooked. However,
throughout centuries, Islamic scholars have contributed significantly to human
physical and mental health with the inspirations drived from the Holy Qur’an.
Nevertheless, it is pleasing to see that recently, there is a growing interest
and research in this field. In this paper, Ahmed Abu Zayd al-Balkhi's (849-934)
ideas about mental health in his work “Sustenance
for Body and Soul” are examined and evaluated in accordance with the
findings of modern psychology.
NOSTRA AETATE’NİN İLAN SÜRECİ:DE JUDAEIS’TEN NOSTRA AETATE’YE
Authors: Çoban Bekir Zakir 
Published: March 2018

Nostra Aetate II. Vatikan Konsili’nin önemli belgelerinden biridir. Bu
belgede Kilise, tarihinde ilk defa diğer din mensuplarından olumlu bir dille
bahsetmektedir. Nevar ki bu metnin önce sadece Yahudilere yönelik bir
deklerasyon olarak planlanmış, fakat konsil sürecinde çeşitli değişimlere
uğrayarak en son Müslümanlar da dahil olmak üzere Hıristiyanlar dışındaki din
mensuplarıyla ilgili bir belge halini almıştır. Biz burada Yahudilerle ilgili
düşünülen ilk taslak olan Decretum de Judaeis’ten Nostra Aetate’ye nasıl
gelindiğini ele alacağız. Ardından metinle ilgili farklı kesimlerden ne tür
tepkiler geldiğini değerlendirmeye çalışacağız.&nbsp;
ANLAMA BAĞLAMINDA DİRİLİŞLE İLGİLİ BAZI ÂYETLERE BAKIŞ
Authors: Şahin İskender 
Published: March 2018

Kur'ân-ı Kerîm'in ana konularından birisi de diriliş inancıdır. Söz
konusu akide, diğer inanç esaslarını temellendiren ve sağlamlaştıran bir
özelliğe sahiptir. Dolayısıyla diriliş ile ilgili âyetlerin doğru anlaşılıp
yorumlanması oldukça önemlidir. Tefsir geleneği içerisinde diriliş ile ilgili
birtakım âyetlerin anlaşılmasında bazı problemlerin olduğu görülmektedir. Bu
problemler, genellikle âyetlerin siyak ve sibaka dikkat etmeksizin bir bütünlük
içerisinde değerlendirilememesinden ve yeterli derecede kavramların
araştırılmamasından kaynaklanmaktadır. Oysa farklı şekillerde anlaşılan
âyetler, tespit edilen hususlar dikkate alındığında diriliş ile ilişkili
oldukları görülecektir. Dolayısıyla tefsir faaliyetlerinde bulunan
araştırmacıların Kur'an çalışmalarında bu hususlara dikkat etmeleri âyetlerin
daha iyi anlaşılıp yorumlanmasına zemin hazırlayacaktır.&nbsp;
ABDÎ EFENDİ’NİN TASAVVUF RİSÂLESİ
Authors: Çavuşoğlu Raşit 
Published: March 2018

Bu çalışmada Abdî Efendi’nin bazı
tasavvufî hakîkatleri barındıran risâlesi işlenmektedir. Nakşibendiyye tarîkatı
esaslarından olan letâif-i hamse başta gelmek üzere rüya, müşâhede ve mükâşefe
gibi tasavvufî konuların işlendiği risâle dört bölümden müteşekkildir. İnsan
nefsine bahşedilen beş hissin tasavvufî terbiyedeki önemi vurgulanarak başlayan
eser, bu beş temel hisle batınî hakîkatlerin idrak edilebileceğini ve sâlikin
seyr ü sülûkunu bu makamlara uygun yaptığı zikirler vasıtasıyla tamamlayacağını
ifade eder. Çalışmamızın giriş bölümünde eserle ilgili genel bir değerlendirme
yapılmıştır. Birinci bölümde, risâle müellifi Abdî Efendi’nin kimliği
tartışmaya açılmış, risâlenin konusu ve muhtevası hakkında detaylı malumat
verildikten sonra yine bu bölümde eserin yazma nüshasının tavsifi yapılmıştır.&nbsp; İkinci bölümde ise, risâlenin transkripsiyonlu
metni verilmiştir.&nbsp;
TÜRKİYE’DE MANEVİ DANIŞMANLIK VE REHBERLİK LİTERATÜRÜ ÜZERİNE BİBLİYOGRAFİK BİR ÇALIŞMA
Authors: Yenen İlker 
Published: March 2018

Bu çalışmada Türkiye’de Manevi Danışmanlık ve Rehberlik
üzerine yapılan çalışmaların bibliyografik bilgileri yer almaktadır. Bu makale,
1963-2017 yılları arasında Türkiye’de yapılmış ve yapılmakta olan akademik
çalışmaları sunmaktadır. Çalışmanın temel amacı, Manevi Danışmanlık ve
Rehberlik alanında yapılan çalışmalar hakkında araştırmacılara katalog bilgisi
vermektir. Makalede yöntem olarak tüm çalışmalar sırasıyla doktora tezleri,
yüksek lisans tezleri, makaleler, tebliğler ve kitaplar şeklinde tasnif
edilmiştir. Ayrıca söz konusu çalışmalar, kendi başlıkları altında alfabetik
olarak sıralanmıştır.
İSVEÇ’TE DİN VE DEVLET İLİŞKİLERİNİN SEKÜLERLEŞME BAĞLAMINDA İNCELENMESİ
Authors: Kılıç Seray 
Published: March 2018

1593 yılındaki Uppsala Meclisi ile
Evanjelik Lüteryen öğretiyi resmi din olarak kabul eden İsveç Krallığı, XVIII.
yüzyıldan itibaren uyguladığı reformlar ile din ve devlet ilişkileri bağlamında
tarafsızlık politikasına doğru ilerlemiştir. 2000 yılında alınan bir kararla
devlet ve İsveç Kilisesi arasındaki resmi bağın sona ermesi bu anlamda önemli
bir adım olarak kabul edilmekle birlikte dini örgütlere ilişkin yasal
düzenlemeler ve bu örgütlerin toplumsal yapılanma içindeki konumu hala
tartışılmaktadır. Bu çalışmanın amacı İsveç’te din ve devlet arasındaki ilişkileri,
tarihsel gelişimini ve mevcut durumunu, sekülerleşme kuramı bağlamında
incelemektir. Yasalar, komisyon raporları ve yazındaki diğer çalışmalar
üzerinden yapılan inceleme neticesinde İsveç’in üç nedenle kendine özgü bir
vaka olduğu anlaşılmaktadır. İlk olarak, İsveç’teki mevcut durum uzun yıllar
süren, siyasi ve dini otoriteler arasındaki müzakerelerin neticesidir. İkinci
olarak, bu reform süreci dini ve siyasi otoriteler arasındaki güç paylaşımı
üzerinden değil demokratik bir devletin unsuru olarak inanç özgürlüğü temelinde
yürütülmüştür. Son olarak, İsveç Kilisesi ile devlet arasındaki ayrılığın
fiilen ve tam anlamıyla gerçekleşmediği, bu iki otorite arasındaki ilişkinin
hala muğlak olduğu görülmüştür. Bu durum, geleneksel dini pratiklerin toplumsal
yapı içindeki işlevselliğinin geçerliliğini korumasından ileri gelmekte olup
İsveç’i sekülerleşme kuramı içinde kendine özgü bir yere koymaktadır.
A Fossilized Language Pattern for the Singular First Person Subject Pronoun in the Saudi Context: I vs. I am
Authors: Rakab Mehmet Bulent 
Published: March 2018

<p><em>The drive that motivated this study was an English as a Foreign Language (EFL) teacher’s observation of a fossilized grammar pattern produced by students over an extended period of time. The fossilized pattern “I am go” frequently emerges in the EFL context of Saudi Arabia, for which a number of factors could be accountable,</em><em> including overgeneralization of a grammar pattern, inadequate instruction, lack of negative and corrective feedback, being frequently exposed to peers’ production of the fossilized pattern, and so forth. 155 undergraduate students from a Saudi university responded to a multiple-choice question with three options. The findings revealed that only one third of the participants identified the correct singular first person subject pronoun in English “I”, which corresponded to (</em>انا<em>) in Arabic. Based on the results, pedagogical and methodological recommendations are made as to how the possibility of the emergence of the incorrect pattern</em><em> in question can be reduced or minimized.</em></p><p> </p>
In-Class Online Discussion Activities to Enhance EFL Learners’ English Self-Efficacy and Language Learning Strategies
Authors: Yang Pei-Ling 
Published: March 2018

The study aims to investigate the effect of in-class online discussion on EFL college low-achievers’ English self-efficacy and their language learning strategies. It integrates the features of quasi-experimental research to examine whether online discussions would enhance college low-achievers’ English self-efficacy and their learning strategy application. Two classes of the college learners from one university were randomly recruited in the study. Two questionnaires (English self-efficacy and language learning strategies) were administered both before and after the intervention. Besides the descriptive analysis of the learners’ background information, a series of inferential statistics were conducted to demonstrate findings from the quantitative data. The study results reveal two significant findings. First, the participants applied language learning strategies more frequently. Second, the participants had higher levels of English self-efficacy.
ESL Reading Accuracy: The Inside Story
Authors: Mohd Rawian Rafizah , Mokhtar Ahmad Azman 
Published: March 2018

<p>Accuracy has received countless and endless attention from language researchers due to its role in language learning. As such, a study is conducted to discover and understand the possible influence of accuracy in second language learning specifically in reading. Its findings will reveal whether accuracy does actually affect reading or vice versa. Simultaneously, the findings will then expose the extent of the possible influence as well as the aspects that may be affected. Its respondents are students who are taking Basic English Language course. Purposeful random sampling technique is used to single out the respondents in terms of their (1) gender and (2) academic semester. An in-depth interview protocol is used to gather data from the selected respondents. An interview checklist is used to ensure the smoothness of the data gathering. An interview guide is prepared beforehand to ensure all important issues are explored. The interview questions are prepared in two versions: English and Malay language.</p>