bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry 4.0 in the supply chain: a proposal for the management of healthcare with a focus on materials and medicines
Authors: Ravaglia Claudia Carrijo , Scavarda Annibal , Dias Ana , Silveira Haydee 
Published: November 2024

PurposeThe objective of this paper is to investigate how Industry 4.0 technologies can contribute to solve the problems of managing materials and medicines in the hospital supply chain, identifying opportunities for their adoption, evaluating their potential and impacts on this segment. This paper also plans to investigate the challenges involving change management, financial impacts and major changes in the process with the introduction of new technologies.Design/methodology/approachThe research carried out a literature review using the CAPES Periodicals portal, which includes renowned scientific bases, like Scopus and Web of Science. The intention was to identify problems in the logistics of materials and medicines in hospital pharmacy. In addition, a second search was carried out in papers related to Industry 4.0 and the supply chain. Subsequently, it was listed how Industry 4.0 technologies could influence the management of the hospital supply chain, on materials and medicines.FindingsThe new technologies of Industry 4.0 identified in the research can contribute to the improvement of the hospital management supply chain, benefiting from a higher level of automation, control and security presented in the research. Thus, the article addresses a new perspective in the management of materials and medications in hospital pharmacy, adding value to the topic, as new technologies can provide more safety to patients, savings for hospital management, reducing waste and environmental impacts.Originality/valueThe automation of the supply chain, in the materials and medicines segment, in hospital environments, adopting Industry 4.0 techniques, will make it possible to differentiate hospital management, generating great added value, benefiting the entire chain. The combination of technologies such as IoT, BigData and artificial intelligence, applied to the management of materials and medicines, will allow real-time management; consumption and stock estimates; more agile and reliable decision-making process; greater economic efficiency, in addition to contributing to patient safety.
Strategy adaptation under external uncertainty: examining speed-based competitions
Authors: Huang Ying , Mu Wenlong 
Published: November 2024

PurposeDespite the growing attention being paid to the role of uncertainty in the competitive business environment, few studies have considered uncertainty as an antecedent factor and explored its direct impact on accelerating a firm’s innovation speed. This study develops a conceptual framework that examines the impacts of technological uncertainty and market uncertainty on innovation speed, building on complex adaptive theory. Furthermore, it is important to note that the internal resources of a firm and its external environment are not separate entities. In this study, we investigate the moderating role of a firm's internal and external resource ability (financial constraints level and organizational slack level) in the relationship between environmental uncertainty and innovation speed.Design/methodology/approachOur data sample is the panel data of China's A-share listed companies. The data year span is from 2000 to 2018. We use a hierarchical regression analysis model.FindingsOur results reveal that both technology uncertainty and market uncertainty can promote innovation speed. Still, a firm’s organizational slack positively moderates the relationship between technology uncertainty and innovation speed, and financial constraints negatively moderate the relationship between demand uncertainty and innovation speed.Originality/valueOur research contributes to the existing literature on uncertainty and extends its research perspective by no longer taking uncertainty as an environmental factor but exploring its direct impact. Still, our research focuses on innovation speed and discusses the impact of environmental uncertainty (including technology uncertainty and demand uncertainty) on firms’ innovation speed, expanding the limitations of previous research, which usually holds a relatively general perspective on innovation problems.
Knowledge and attitudes of nurses toward caring of older people in primary health-care centers at South of Jordan
Authors: Alhroub Nisser , Al-Sarairhe Ishraq , Alkhawaldeh Abdullah , ALBashtawy Mohammed , Al Omari Omar , Salameh Basma , Batran Ahmad , Ayed Ahmad , Ababneh Anas , Abdalrahim Asem , ALBashtawy Zaid 
Published: November 2024

Purpose
This study aims to assess the knowledge and attitudes of 420 nurses toward caring for older people in primary health-care centers in the southern region of Jordan.

Design/methodology/approach
Data collected through an electronic survey was analyzed using the Statistical Package for the Social Sciences (SPSS) version 23.0.

Findings
The findings revealed that 91.0% of nurses had limited knowledge, with only 7.1% demonstrating average knowledge and 1.9% showing good knowledge about older people care. Furthermore, 85.2% of participants held neutral attitudes toward aged care, while 12.4% had positive attitudes and 2.4% exhibited negative attitudes. A significant correlation was observed between knowledge and attitude scores (p-value = 0.000). Gender and marital status were found to influence attitudes, with significant statistical relationships (p-values: gender = 0.000, marital status = 0.004). These results emphasize the importance of improving nursing education in geriatric care and promoting positive attitudes toward caring for older people patients.

Practical implications
The study highlights the need for ongoing professional development to enhance patient outcomes and the quality of care for the older people population. Further longitudinal research and comparative analyses are recommended to deepen the understanding of knowledge and attitudes across various health-care settings.

Originality/value
The study revealed a significant correlation between nursing practitioners’ knowledge and attitudes toward geriatric care, with gender and marital status significantly influencing attitudes, while age did not. This underscores the need for further research.
Assessing the effect of tissue and fire‐response traits on plant growth rates post‐disturbance in eastern Australia
Authors: Ford Ashleigh M. , Grootemaat Saskia , Towers Isaac , Maslen Ben , Cornwell Will K. , Ooi Mark K. J. , Falster Daniel S. 
Published: November 2024

Abstract

Variation in plant growth strategies facilitate species' coexistence in a community. Some functional traits are predicted to influence the growth rates of developing individuals by capturing trade‐offs in resource allocation. However, despite being used broadly in community ecology, the assumed generality and predictability of trait‐growth relationships lack widespread empirical testing.

The megafires of 2019–2020 burned extensive areas throughout New South Wales and were followed by high rainfall, causing the large‐scale synchronous regeneration of fire‐adapted species. We took advantage of this mass disturbance event to test hypothesised relationships between functional traits and growth across six spatially distributed sclerophyllous systems throughout NSW, in which sampled vegetation was part of the same growth cohort.

We investigated whether resprouting as a trait facilitated faster initial height growth compared to reseeding and, in reseeding species, tested whether the effects of four structural functional traits—stem specific density (SSD), leaf nitrogen per area, standardised stem diameter and specific leaf area (SLA)—on height growth rates followed directions predicted by theory.

Resprouters grew an average of 25.92 cm year−1 more than reseeders at 14–15 months post‐fire, indicating an advantage in light capture over reseeding species in the period soon after fire. Of the four structural functional traits tested, SSD and leaf nitrogen per area displayed evidence of relationships with height growth rate, while standardised stem diameter and SLA had no evidence of an effect. These relationships were consistent across sites.

Our results indicate that (i) ontogenetic variation in growth rates should be integrated into the fast‐slow growth economics spectrum and that (ii) while some functional traits predict height growth, this is not a guarantee for all traits.

Read the free Plain Language Summary for this article on the Journal blog.
Substitute Yeast Extract While Maintaining Performance: Showcase Amorpha‐4,11‐Diene Production
Authors: Castillo‐Saldarriaga Carlos , Santos Christine N. S. , Sarria Stephen , Ajikumar Parayil K. , Takors Ralf 
Published: November 2024

ABSTRACTYeast extract (YE) is a complex nutritional source associated with high performance on microbial production processes. However, its inherent compositional variability challenges its scalability. While prior efforts have focused on growth‐associated products, the dynamics of growth‐uncoupled production, which leads to higher production rates and conversion yields, still need to be explored. This production scenario is common in large‐scale applications. This study presents a systematic approach to replace YE for the production of the terpene amorpha‐4,11‐diene in Escherichia coli. Sequential processing was successfully applied to identify glutamic acid, alanine, leucine, valine, isoleucine and glycine as the key amino acids (AAs) under slow‐growth conditions. Thoroughly applying biomass retention as part of sequential processing increased production capacity by 45% using these AAs instead of YE. Further studies, including flux balance analyses, targeted pyruvate as the common AA precursor. The optimized fed‐batch process feeding pyruvate with 0.09 gPyr h−1 enhanced amorpha‐4,11‐diene production by 37%, although adding only 1% carbon via pyruvate. Flux balance analysis revealed the criteria for optimum pyruvate feeding, for example, to prevent succinate secretion and maintain the NADH/NAD+ balance. These findings illustrate the interplay between media composition and metabolic activity and provide a successful guideline for identifying lean, best‐performing media for industrial applications.
Understanding the tolerance of halophilic archaea to stress landscapes
Authors: Matarredona Laura , Zafrilla Basilio , Camacho Mónica , Bonete María‐José , Esclapez Julia 
Published: November 2024

AbstractHaloarchaea, known for their resilience to environmental fluctuations, require a minimum salt concentration of 10% (w/v) for growth and can survive up to 35% (w/v) salinity. In biotechnology, these halophiles have diverse industrial applications. This study investigates the tolerance responses of nine haloarchaea: Haloferax mediterranei, Haloferax volcanii, Haloferax gibbonsii, Halorubrum californiense, Halorubrum litoreum, Natrinema pellirubrum, Natrinema altunense, Haloterrigena thermotolerans and Haloarcula sinaiiensis, under various stressful conditions. All these archaea demonstrated the ability to thrive in the presence of toxic metals such as chromium, nickel, cobalt and arsenic, and their tolerance to significantly elevated lithium concentrations in the medium was remarkable. Among the studied haloarchaea, Hfx. mediterranei exhibited superior resilience, particularly against lithium, with an impressive minimum inhibitory concentration (MIC) of up to 4 M LiCl, even replacing NaCl entirely. Haloferax species showed specificity for conditions with maximal growth rates, while Htg. thermotolerans and Nnm. altunense displayed high resilience without losing growth throughout the ranges, although these were generally low. ICP‐MS results highlighted the impressive intracellular lithium accumulation in Nnm. pellirubrum, emphasizing its potential significance in bioremediation. This research highlights a new characteristic of haloarchaea, their tolerance to high lithium concentrations and the potential for new applications in extreme industrial processes and bioremediation.
Analysis of chemical and morphological properties of root dentine treated with a single multifunctional endodontic irrigant solution
Authors: de Castro‐Vasconcelos Gustavo A. , de Assis Helena C. , Ramirez Iago , Teodosio Leonardo M. , Jacob Gabrielle , Roperto Renato , Sousa‐Neto Manoel D. , Mazzi‐Chaves Jardel F. , Lopes‐Olhê Fabiane C. 
Published: November 2024

AbstractThe aim was to evaluate the chemical, morphological aspects and microhardness of root dentin after treatment with Triton™ solution. Twenty blocks of root dentin were distributed in two groups (n = 10): Control (C) (2.5% NaOCl+17% EDTA+2.5% NaOCl) and Triton™ solution (T). Morphological analysis was performed before and after treatments with confocal laser microscopy. Chemical composition and microhardness were analysed after the treatments using Raman spectroscopy and Knoop microhardness. Results were submitted to Student's t‐test and Mann–Whitney test (p < 0.05). The C group had greater tubule number, area and perimeter (p < 0.001), besides a regular surface, while T showed an irregular surface with cracks and erosions, lower organic content intensity (p < 0.001) and higher inorganic/organic ratio (p = 0.003) than C, which had higher microhardness than T (p = 0.003). Triton™ exposed a lower number, area and perimeter of dentinal tubules, with cracks and erosions in root dentin. It also showed significant chemical alterations in the organic content, reducing it, resulting in lower microhardness.
Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration
Authors: Doerr Adrian A. , Dings Christiane , Zaher Omar , Nordmeier Frederike , Walle Nadja , Laschke Matthias W. , Menger Michael D. , Schmidt Peter H. , Meyer Markus R. , Lehr Thorsten , Schaefer Nadine 
Published: November 2024

AimsSince their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse. As an alternative to human studies not being allowed for ethical reasons, a sophisticated pig model was applied in the present study to assess the TK of the SC 5F‐MDMB‐P7AICA.MethodsPigs pulmonarily received 5F‐MDMB‐P7AICA via an ultrasonic nebulizer. The parent compound and its main metabolite 5F‐MDMB‐P7AICA dimethyl butanoic acid were determined in serum and whole blood using liquid chromatography–tandem mass spectrometry. Obtained data was analysed by population (pop) TK modelling. The final pop TK model parameters for pigs were upscaled via allometric scaling techniques for the prediction of human exposure.ResultsThe serum concentration–time profiles of the parent and the pop TK analysis revealed that a 4‐compartment model best describes the TK data. The administration of the aerosol into the lung compartment follows zero‐order kinetics. A transit compartment was further included to accurately describe the time delay between detection of the parent and the metabolite. Despite the different structure, TK parameters were found to be comparable to other examined SC.ConclusionThe predictions of human SC exposure suggest that multiple administration of 5F‐MDMB‐P7AICA substantially enhances the window of detection. The simulations pose extrapolation of the data used for model development with respect to dose linearity and allometric scaling to humans.
Micropapillary structure: A natural tumor collective invasion model with enhanced stem‐like properties
Authors: Li Sisi , Gao Shuangshu , Qin Ling , Ding Caixia , Qu Jinghui , Cui Yifei , Qiang Lixia , Yin Shengjie , Zheng Xiaoyu , Meng Hongxue 
Published: November 2024

AbstractCancer stem cells aggregate to form clusters, which have enhanced stem‐like properties and metastasis potential. However, the molecular mechanisms underlying the formation of cancer stem cell cluster‐like structures with acquisition of stronger invasion and metastasis abilities remain unclear. Micropapillary carcinoma (MPC) is a subpopulation of small, merulioid, inverted, nonfibrous vascular clusters floating in the stroma present in a range of solid malignant tumors and characterized by frequent vascular/lymphatic vessel invasion and lymph node metastasis. Our results showed that these cell clusters exhibit a stem cell phenotype, supporting the premise that MPC may serve as a promising solid tumor model for studying invasion and metastasis of cancer stem cell clusters. In this review, we discuss the latest advances in MPC research and targeted therapy, focusing on analysis of their stem‐like characteristics, mapping their multiomics characteristics, and elucidating the vascular and immune microenvironment of MPC. The existing MPC organoid model was employed to explore potential breakthroughs in targeted therapy and immunotherapy for cancer stem cell clusters.
One or two? Comparison of the cardiorenal effects between combination therapy and monotherapy with SGLT2i or GLP1RA
Authors: Zhang Mengqing , Lin Chu , Cai Xiaoling , Jiao Ruoyang , Bai Shuzhen , Li Zonglin , Lv Fang , Yang Wenjia , Liu Geling , Yang Xiaolin , Ji Linong 
Published: November 2024

AbstractObjectiveThis study aimed to evaluate the cardiorenal effect of combining sodium‐glucose cotransporter 2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) when compared with monotherapy of either agent in patients with type 2 diabetes (T2D).MethodsPubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov were systematically searched from inception to June 2024. Eligible studies included randomised controlled trials and observational studies assessing that compared with SGLT2i or GLP‐1RA monotherapy, the risk of cardiorenal outcomes in patients with T2D who treated with combination therapy. Pooled relative risk (RR) and 95% confidence intervals (CIs) were computed in random‐effects model.ResultsIn all, five RCTs, 10 post hoc analyses and one observational study were included. The reduced risk of the composite cardiovascular outcome was observed in patients receiving combination therapy of SGLT2i and GLP‐1RA when compared with SGLT2i monotherapy (RR = 0.57, 95% CI 0.38–0.86, p = 0.008) or GLP‐1RA monotherapy (RR = 0.77, 95% CI 0.65–0.91, p = 0.002). Likewise, the composite renal adverse events were less frequent in patients receiving combination therapy of SGLT2i and GLP‐1RA when compared with SGLT2i monotherapy (RR = 0.69, 95% CI 0.59–0.82, p < 0.001) or GLP‐1RA monotherapy (RR = 0.66, 95% CI 0.53–0.83, p < 0.001). Compared with GLP‐1RA monotherapy, the combination therapy of SGLT2i and GLP‐1RA was associated with lower risks of heart failure–related outcomes (RR = 0.63, 95% CI 0.51–0.77, p < 0.001) and all‐cause mortality (RR = 0.66, 95% CI 0.50–0.88, p = 0.004) in patients with T2D.ConclusionThe cardiorenal benefits might be magnified with the combination therapy of SGLT2i and GLP‐1RA when compared with monotherapy of either agent. Further investigations are needed to validate the findings.
Entrepreneurship as strategic network creation: A relational practices perspective
Authors: Sydow Jörg , Schmidt Thomas 
Published: November 2024

AbstractOften entrepreneurship may be more about the strategic creation of an interorganizational network than of an organization. Based on a revelatory case study from a rather traditional industry in a vibrant entrepreneurial ecosystem, we argue that once startups replace organization creation by means of network creation they are confronted with a series of tensions that have to be managed in the unfolding process. We analyze how tensions at the beginning of the entrepreneurial journey – being unknown in the field, lacking an elaborated organization, and facing competition – are tackled under these circumstances with relational practices. Our findings enrich the body of research on entrepreneurship and interorganizational networks by unearthing those relational practices that help – across analytical levels and time – to address legitimacy, complexity, and reciprocity challenges.
Phenotype–genotype correlation in X‐linked Charcot‐Marie‐Tooth disease: A French cohort study
Authors: Barbat du Closel Luce , Bonello‐Palot Nathalie , Delmont Emilien , Péréon Yann , Echaniz‐Laguna Andoni , Camdessanché Jean Philippe , Pakleza Aleksandra Nadaj , Chanson Jean‐Baptiste , Frachet Simon , Magy Laurent , Cassereau Julien , Cintas Pascal , Choumert Ariane , Devic Perrine , Louis Sarah Léonard , Tard Céline , Solé Guilhem , Salort‐Campana Emmanuelle , Bouhour Françoise , Latour Philippe , Stojkovic Tanya , Attarian Shahram 
Published: November 2024

AbstractBackground and purposeX‐linked Charcot‐Marie‐Tooth disease type 1 (CMTX1) ranks as the second most prevalent hereditary neuropathy and, currently, has no definitive cure. Emerging preclinical trials offer hope for potential clinical studies in the near future. While it is widely accepted that experimental groups in these trials should be balanced for age and gender, there is a current shortfall in data regarding phenotype–genotype correlations. Our aim was to provide a more detailed understanding of these correlations to facilitate the formation of well‐matched patient groups in upcoming clinical trials.MethodsWe conducted a retrospective evaluation of CMTX1 patients from 13 designated reference centers in France. Data on genetics, clinical features, and nerve conduction were systematically gathered.ResultsWe analyzed the genotype–phenotype correlations in 275 CMTX1 patients belonging to 162 families and carrying 87 distinct variants. Patients with variants affecting the transmembrane domains demonstrated significantly greater severity, as evidenced by a Charcot‐Marie‐Tooth Examination Score of 10.5, compared to 7.1 for those with intracellular domain variants and 8.7 for extracellular domain variants (p < 0.000). These patients also experienced an earlier age of onset, showed slower ulnar nerve conduction velocities and had more substantial loss of motor amplitude.ConclusionsThis study confirms the presence of a correlation between the mutated protein domain and the clinical phenotype. Patients with a variant in the transmembrane domains demonstrated a more severe clinical and electrophysiological profile. Consequently, the genotype could play a prognostic role in addition to its diagnostic role, and it will be essential to consider this in future clinical trials.