bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics and Comorbidity network analysis of Colorectal cancer
Authors: Ljubic Branimir , Pavlovski Martin , Alshehri Jumanah , Bajic Vladimir , Neste Christophe Van , Obradovic Zoran , Roychoudhury Shoumik 
Published: August 2019

Abstract
Background Colorectal cancer (CRC) is the third most common cancer in the United States, and the second leading cause of cancer death. Comorbidity network analyses of CRC can help understanding of the illness progression. About 10%-30% of patients have a family history of CRC that suggests a hereditary contribution, including pathogenic variants of genes. The goal was to identify comorbidities associated with CRC and to discover pathogenic variants of genes that could be connected to CRC and comorbidity diseases. Results A novel model is developed based on comorbidity networks, to study progression of CRC. The model was developed on the HCUP, SID California inpatient database for a period of 9 years (2003-2011). Comorbidity networks, and Venn diagrams show probabilities of occurrence of comorbidities associated with different stages of CRC. Ranked lists of comorbidities (more than 5,800) were utilized for text mining of PubMed and expert curated sources (DisGeNet), to identify genes associated with CRC. Associations between 1,940 different genes and CRC were extracted from PubMed. 150 different genes are associated with CRC in DisGeNet. 96 genes are present in both sources (PubMed and curated sources). The most mentioned gene associated with CRC were: TP53 (241 abstracts in PubMed), APC (115), and KRAS (106). All 3 genes had DisGeNet scores of 0.5. Two more genes (MLH1 – 98 abstracts and TGFBR2 - 18 abstracts) had the same DisGeNet scores. PPARG gene (43 abstracts) had DisGeNet score of 0.6. Genes described on the cancer.gov website were found on PubMed too. MUTYH was described in association with CRC in 7 abstracts, MSH6 in 25 abstracts, PMS2 in 11, EPCAM in 10, POLD1 in 4, BMPR1A in 3, SMAD4 in 15, PTEN in 25 and STK11 in 8 PubMed abstracts. Lists of associations of the six most common genes and comorbidities of CRC were also created. Conclusions Results of the study could be considered as a novelty contributing to better understanding of risk factors (genes, comorbidities) for the development of CRC. Genetic findings could lead to the improvement of guidelines for genetic testing of patients that are at increased risk to develop CRC.
Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience
Authors: Zhang Jianjun , Huang Yujing , Sun Yuanjue , He Aina , Zhou Yan , Hu Haiyan , Yao Yang , Shen Zan 
Published: August 2019

Abstract
Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults. 81 patients treated between January 2005 and December 2017 were included in the present study. 33 (40.7%) presented with metastatic disease at diagnosis. 8 patients were submitted to primary surgery followed by chemotherapy, while 73 patients received chemotherapy before and after surgery and/or local radiotherapy. The chemotherapy regimen included 8-17 cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE) every 3 weeks. Clinical outcomes and safety were analyzed. The results indicated that VDC/IE chemotherapy was well tolerated in adult patients with ES. Multivariate Cox regression analyses revealed that chemotherapy of at least 12 cycles was a favorable independent prognostic factor of event-free survival (hazard ratio, 0.558; 95% confidence interval, 0.323-0.965; P = 0.037) and overall survival (hazard ratio, 0.424; 95% confidence interval, 0.240-0.748; P = 0.003). Similarly, a low frequency of chemotherapy delays was an independent prognostic factor of improved OS (hazard ratio, 0.438; 95% confidence interval, 0.217-0.887; P = 0.022). In conclusion, our study suggests that adults with ES should be treated with an aggressive multidisciplinary approach, intensive chemotherapy with adequate cycles and appropriate intervals can be recommended in this group.
Molecular characterization and structure of intestinal micro flora for postmortem interval estimation in SD rats
Authors: Li Huan , Yuan Lu , Liu Ruina , Zhang Siruo , Yang E , Ullah Shakir , Mushtaq Nosheen , Wu Di , Shi Yi , An Cuihong , Liu Hailong , Wang Zhenyuan , Xu Jiru 
Published: August 2019

Abstract
Background
The human rectum flora consists of a huge variety of bacteria and the association between individuals and their rectum bacterial community begins presently after birth and continues the whole lifetime. Once the body dies, the inherent microbes begin to break down from the inside and play a key role thereafter.
Results
The aim of this study was to investigate the probable shift of the rectum flora at different time intervals up to 15 days after death and to characterize the contribution for of this shift to estimate the time of death. The rectum of rats was wiped with a sterile cotton swab and the samples were proceeded for DNA extraction, PCR amplification of the 16S rRNA gene with the V3+V4 variable regions, and high throughput sequencing carried out on IonS5TMXL platform. The results were analyzed for intra-group and inter-group diversity, similarity and difference at different time points. At phylum level, Proteobacteria and Firmicutes showed major shifts, checked at 11 different intervals and emerged in the most of postmortem intervals. At the genus level, Enterococcus appeared in all groups except alive samples, Lactobacillus and Proteus appeared in most time points, and the latter showed an increasing trend after 3 days postmortem samples. At the species level, Enterococcus_faecalis and Proteus_mirabilis existed in most postmortem intervals, and the former had a downward trend after day 5 postmortem, while the latter had an upward trend. Corynebacterium_amycolatum , Entero_isolate_group_2 , Bacteroides_uniformis , Enterococcus_faecalis , Streptococcus_gallolyticus_subsp_macedonics , Clostridium_sporogenes were more abundant in 0-hour, day 1, 3, 5, 7, 13 postmortem intervals, respectively, while Proteus_mirabilis and Vagococcus_lutrae were abundant in day 15 postmortem. In addition, functional capacity analysis of Membrane_Transport, Amino_Acid_Metabolism, Nucleotide_Metabolism and Energy_Metabolism showed significant differences between alive and almost all other time points after death ( P <0.05).
Conclusions
All in all, bacteria at different levels (phylum, genera, species) showed different characteristic during the process of decomposition and possessed entirely different relative abundance and the structure of bacterial community in each time point shifted obviously, which suggested that the specific bacteria might imply the specific postmortem interval during decomposition.
Current status of oxacillin-susceptible mecA-positive Staphylococcus aureus infection in Shanghai, China: A multicenter study
Authors: Liu Junlan , Li Tianming , Zhong Ni , Wang Xing , Jiang Jie , Zhang Wenxia , Tang Rong , Guo Yinjuan , Liu Yun , Hu Jiang , He Lihua , Tang Jin , Wu Wenjuan , Li Min 
Published: August 2019

Abstract
The worldwide reported oxacillin-susceptible mecA -positive Staphylococcus aureus (OS-MRSA) represents a distinctly important challenge to detection and treatment of MRSA, but finite data on current status of OS-MRSA infection in Chinese hospitals are available. The present multicenter study carried out a battery of phenotypic susceptibility tests as well as diagnostic tests (PBP2a detection, mecA , and mecC PCR) for a collection of 956 clinical S. aureus isolates from 10 hospitals in Shanghai, molecular typing was performed for all identified OS-MRSA strains. OS-MRSA represented 1.8% (17/956) of total isolates and were commonly borderline oxacillin-susceptible (Oxacillin-MIC of 1 or 2 mg/L). 10 of 17 OS-MRSA were ST59 lineages, followed by ST965 (3/17). Unlike oxacillin-resistant MRSA that commonly exhibit a multidrug resistant (MDR) phenotype, OS-MRSA were less likely to be MDR and displayed MIC pattern remarkably differential from OR-MRSA. OS-MRSA showed oxacillin-inducible oxacillin resistance and the majority of them (15/17) were cefoxitin-resistant by cefoxitin disk diffusion. S. aureus with borderline susceptible oxacillin MICs (1 or 2 mg/L) should be confirmed by cefoxitin disk diffusion in clinical practice, whereas susceptible isolates reclassified by cefoxitin disk diffusion should still be subjected to PBP2a testing and (or) mecA (mecC) PCR. The presented study has characterized phenotypically and molecularly an atypical type of MRSA showing cryptic but inducible resistance to oxacillin, but its underlying mechanisms warrant further elucidation.
An improved catalogue of putative synaptic genes defined exclusively by temporal transcription profiles through an ensemble machine learning approach
Authors: Obregón Flavio Pazos , Soto Pablo , Palazzo Martín , Guerberoff Gustavo , Yankilevich Patricio , Cantera Rafael 
Published: August 2019

Abstract
Background . Assembly and function of neuronal synapses require the coordinated expression of a yet undetermined set of genes. Previously, we had trained an ensemble machine learning model to assign a probability of having synaptic function to every protein-coding gene in Drosophila melanogaster. This approach resulted in the publication of a catalogue of 893 genes which we postulated to be very enriched in genes with a still undocumented synaptic function. Since then, the scientific community has experimentally identified 79 new synaptic genes. Here we use these new empirical data to evaluate our original prediction. We also implement a series of changes to the training scheme of our model and using the new data we demonstrate that this improves its predictive power. Finally, we added the new synaptic genes to the training set and trained a new model, obtaining a new, enhanced catalogue of putative synaptic genes.

Results . The retrospective analysis demonstrate that our original catalogue was significantly enriched in new synaptic genes. When the changes to the training scheme were implemented using the original training set we obtained even higher enrichment. Finally, applying the new training scheme with a training set including the 79 new synaptic genes, resulted in an enhanced catalogue of putative synaptic genes. Here we present this new catalogue and announce that a regularly updated version will be available online at: http://synapticgenes.bnd.edu.uy

Conclusions . We show that training an ensemble of machine learning classifiers solely with the whole-body temporal transcription profiles of known synaptic genes resulted in a catalogue with a significant enrichment in undiscovered synaptic genes. Using new empirical data provided by the scientific community, we validated our original approach, improved our model an obtained an arguably more precise prediction. This approach reduces the number of genes to be tested through hypothesis-driven experimentation and will facilitate our understanding of neuronal function.

Availability : http://synapticgenes.bnd.edu.uy
Alkaline Hydrolyzable‐Nitrogen of Clayey Soils Reduces Supplemental Fertilizer Nitrogen Requirement of Rice in Arkansas
Authors: Fulford Anthony M. , Roberts Trenton L. , Norman Richard J. , Slaton Nathan A. , Greub Chester E. , Davidson Jarom T. 
Published: August 2019

The Illinois Soil Nitrogen Test (ISNT) and the Nitrogen Soil Test for Rice (N‐STaR) are alkaline hydrolyzable‐N (AH‐N) soil test methods that can potentially improve N fertilization of cereal crops by predicting a site‐specific fertilizer‐N rate; however, neither method has been evaluated for rice (Oryza sativa L.) grown on clayey soils. The study objectives were to: (i) evaluate unfertilized (0 kg N ha−1) N uptake and yield response of rice to fertilizer‐N based on ISNT and N‐STaR soil test values of clayey soils sampled in 15‐cm increments to a 60‐cm depth and (ii) calibrate the fertilizer‐N rate required to achieve 95% relative grain yield (FN 95%RGY) with ISNT and N‐STaR. A significant and positive linear relationship (P ≤ 0.001) occurred between AH‐N (ISNT or N‐STaR) and rice‐N response, regardless of sampling depth. Unfertilized N uptake, unfertilized yield (Yield0N), or relative grain yield (%RGY0N) regressed on AH‐N exhibited coefficient of determination (r2) values as great as 0.82, 0.59, and 0.78, respectively. The ability of AH‐N to be calibrated to FN 95%RGY was influenced by sampling depth with the greatest r2 values occurring when clayey soils were sampled from ≤30 cm. The ISNT and N‐STaR explained as much as 90 and 95% of the variability in FN 95%RGY, respectively, at the 0‐ to 30‐cm depth. Alkaline hydrolyzable‐N soil test methods, such as ISNT and N‐STaR, provided an accurate indication of rice response to fertilizer‐N and have the potential to improve fertilizer‐N rate recommendations for rice grown on clayey soils.Core Ideas

Inability to predict rice supplemental fertilizer‐N requirement limits usefulness of N recommendations.
Sampling depth influenced correlation between alkaline hydrolyzable‐N and rice fertilizer‐N responsiveness.
Alkaline hydrolyzable‐N accurately predicted supplemental N requirement across variously N‐fertile clayey soils.
Coupled removal of Rhodamine B and Cu2+ by activating persulfate using micron zero-valent iron
Authors: Huo Xiaowei , Liu Yunxin , Liu Sijie , Zhou Peng , Li Haishen , Yang Bo , Yang Dan , Zhang Yongli 
Published: August 2019

Abstract
In this study, micron zero-valent iron (ZVI) was used to activate persulfate (PS) for the coupled removal of Rhodamine B (RhB) and Cu2+. It was observed that the removal of RhB could be significantly enhanced with Cu2+ compared with that of the case without Cu2+. In addition, the reaction reduced the RhB by 96% within 10 min, and meanwhile reduced the Cu2+ by 60% within 120 min. Investigation of the mechanism revealed that, on the one hand, Cu2+ species could be turned into Cu0 and Cu+ species; on the other hand, PS and Cu2+ could first accelerate the corrosion of ZVI to release Fe2+. Then, in situ generated Cu+ and Fe2+ further decomposed PS to produce ·SO4− and ·OH, which could take part in the removal of RhB. In addition, the ZVI/PS/Cu2+ system also showed a wider pH working range than the ZVI/PS system. Our study proved that simultaneous removal of heavy metal and organic compound in the ZVI/PS/Cu2+ system was feasible.
Acompanhamento Terapêutico: considerando a ‘rua’ como suporte de enunciação na clínica das psicoses
Authors: TROIS João Fernando 
Published: August 2019

Este artigo é um ensio sobre a prática do Acompanhante Terapêutico, em suas caminhadas pela cidade, compreendendo a rua como espaço clínico que possa favorecer a construção de condições de enunciações pedestres a seus acompanhados. Busca acompanhar a experiência da errância, na prática da deriva psicogeográfica realizada com sujeitos psicóticos, proposta no projeto de extensão “Isso mostra: Expressões do sujeito. Construindo enlaces sociais pela arte" realizado no Centro Universitário Metodista do Sul - IPA. Este projeto, relaciona as práticas de Acompanhamento Terapêutico ao trabalho em oficinas de criatividade, onde as trajetórias pela cidade transliteram-se em imagens e palavras escritas e desenhadas pelos sujeitos com diagnóstico de psicose. Considera-se que tais práticas permitam a seus participantes construir formas próprias de estar no mundo em situação, em relação, possibilitado um suporte expressivo para si mesmo e para o endereçamento aos seus outros, proporcionando-lhe reconhecer-se num laço social possível.
Monitoring and Evaluation of Thyroid Function Tests, Serum Electrolytes and Creatinine Levels Before and After 131I Therapy
Authors: Mehmood Rubaida , Khan Muhammed S. , Hussain Sajid , Ahmed Akhlaque , Arshad Farhatul-Ain , Mukhtar Rubina 
Published: August 2019

Background:
Serum electrolytes, Creatinine, and thyroid profile play an important role in
131I treated patients of thyroid disorders.

Objectives:
To determine the effect of radioactive iodine (131I) on renal parameters, serum electrolytes
and the correlation among TFT’S, creatinine, and chloride levels before and after I131 treatment in
thyroid disorders.

Methods:
The study was performed on 55 patients of thyrotoxicosis with age ranging from 16-65 years
(mean age= 41±14years and BMI=24.8±4.46). The significance of the differences between the results
of 1st, 2nd, and 3rd-time serum analysis was assessed by paired Student's t-test. Association between
parameters was assessed by Spearman correlation analysis.

Results:
40 patients were taking Carbimazole, and 15 were directly recommended for I131 therapy.
Strongly significant variations were observed for TFT’S (T3=0.012, T4 =0.017, and TSH=0. 001) during
the follow-up treatment. Before taking I131 (Serum analyzed at 1st time), there observed negative
correlation of T3(r=-.46, p=0. 002) and TSH (r=-0.31, p=0.02) with creatinine, and positive correlation
of TSH(r=0.29,p=0.02) with chloride. BMI was negatively correlated with potassium(r=-0.30, p=0.02).
At the 2nd time (after stopping the Carbimazole), no correlation results were observed. Two months
after oral administration of 131I, creatinine, and chloride level was significantly increased (p=0.000),
(P=0. 03) respectively, but had no correlation with TFT’S.

Conclusion:
Our findings suggest that patients with goiter (diffused or toxic) have association of TFT’S
and BMI with serum electrolytes and creatinine, 131I therapy is also associated with the increase in
creatinine and chloride levels of patients leading to kidney problems.
Shear strength of brick mortar interface for masonry in Lima city
Authors: Lavado Luis , Gallardo Jorge 
Published: September 2019

Masonry structures constitute a large proportion of the building inventory in Lima and in most cities in Peru, mainly because of their benefits in terms of low cost, good mechanical properties and easily worked. It was observed in the cyclic loading test of masonry walls carried out at CISMID that the modes of failures can be mainly generated by shear forces. Based on the previous information, it is known that diagonal cracking and slip of the mortar-brick joints are the dominant failure mechanisms of confined masonry walls.
In order to determine the mechanical behavior in the mortar-brick joint, an experimental program was carried out, by using industrial and handmade bricks. The test specimens were specifically designed to transmit pure shear along the bed joints under certain constant levels of compressive stress normal to the bed joint. The results of experimental shear tests are presented and discussed. It is then found a consistency between the behavior of masonry joints under shear with the Mohr Coulomb criterion. The shear failure capacity was influenced by the brick type, pre-compression load level and mortar type. It is also noticed in this experimental study that the pre-compressive stress normal to the bed joints significantly increase the shear strength of the mortar-brick joint.
Self-Assessment of experimental and numerical computer models developed at CISMID based on a bench-mark model developed in Japan at 1994
Authors: Rojas Victor Pool , Rojas Carlos 
Published: September 2019

This article reports the state-of-the-art of the implementation of finite element modeling for clay masonry walls under lateral loads. Important work had been developed at CIMID Laboratory of Structures in clay walls under lateral loads and, according to the review, nowadays, researches mainly report experimental tests with their numerical nonlinear models. This process is important to validate and complement their results. Bench-mark model developed in 1994 at Chiba University had been selected to evaluate all work developed at CISMID in these recently years. The evaluation uses three variables: 1) The study evaluated include experimental results for masonry walls, (2) The study evaluated use nonlinear models for interaction between mortar and bricks, and (3) The study evaluated record their results with graphics showing the failure process. Finally, evaluate these models with finite elements demand high costs because the hardware and software requirements. However, the acquisition of a computer for High Performance Computing is necessary to afford this kind of research.
Análisis de las actividades del plan de manejo ambiental de la Empresa Eléctrica C.A. en la Ciudad de Azogues
Authors: Cabrera-Cárdenas Glenda E. , Solís-Muñoz Juan B. , Quevedo-Vázquez Jorge O. , Ormaza-Andrade Jorge E. 
Published: August 2019

<p style="text-align: justify;">La Empresa Eléctrica Azogues C.A., de acuerdo con lo establecido en la Norma Internacional de Contabilidad N° 37, debe realizar la determinación del valor provisionado por concepto de desmantelamiento, retiro y remediación ambiental de la Subestación Azogues 2 una vez finalizada su vida útil. La Subestación cuenta con un Plan de Manejo Ambiental para la etapa de retiro, realizado en 2009, como parte del Estudio de Impacto Ambiental Definitivo para la construcción y retiro de la Subestación Azogues 2. En el presente documento se procederá a la determinación de los valores que tendrá la ejecución de estas actividades planteadas, según el estudio de mercado con fecha 31 de diciembre de 2016. La investigación siguió un enfoque de tipo cualitativo a partir del método deductivo y del uso de documentos históricos que posee la Empresa Eléctrica Azogues C.A. Asimismo, se seleccionó información de las distintas áreas y se realizaron entrevistas a los colaboradores de todos los departamentos, a fin de corroborar la calidad en cuanto a la atención prestada por la empresa. Entre sus conclusiones se pudo constatar que la Empresa Eléctrica Azogues C.A., a través del acatamiento de las actividades determinadas en el PMA ha logrado cumplir con lo dispuesto en la legislación ambiental vigente, reduciendo impactos negativos de las actividades de la Empresa sobre el entorno, lo cual no sólo beneficia al medio ambiente sino también a la población.</p>
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Incentivo del liderazgo compartido en la Educación Superior
Authors: Lombeida-Carballo Miguel Á. 
Published: August 2019

<p style="text-align: justify;">Los nuevos retos en la educación superior de hoy requieren nuevas formas de liderazgo. Un ambiente financiero muy volátil, el incremento de las asociaciones corporativas internacionales, mayores presiones en la rendición de cuentas, la necesidad de nuevos modelos de negocio, las nuevas tecnologías y los cambios demográficos son solo algunos de estos desafíos, que requieren soluciones de liderazgo que se prueban tanto dentro como fuera de la educación superior. El liderazgo compartido consistentemente surge como un factor clave para las organizaciones que tienen mayor capacidad de aprender, innovar, actuar y adaptarse a los tipos de desafíos externos que los campus ahora enfrentan. El liderazgo compartido se define como alejarse de la figura líder / seguidor; capitalizando la importancia de líderes en toda la organización, no solo los que ocupan cargos de autoridad; y creando una infraestructura para que las organizaciones puedan beneficiarse del liderazgo de múltiples personas.</p>
<p style="text-align: justify;">Este informe examina cómo un contexto ambiental cambiante en la educación superior requiere un nuevo liderazgo, habilidades y enfoques, siendo el principal de ellos los principios del liderazgo compartido. Se revisa el nuevo ambiente de liderazgo, la investigación sobre liderazgo compartido y el pequeño cuerpo de investigación en educación superior.</p>