bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study
Authors: Shaikh Muniza , Siddiqui Salman , Zafar Humaira , Naqeeb Uzma , Subzwari Fakiha , Imad Rehan , Khan Khalid M. , Choudhary Muhammad I. 
Published: February 2019

Background:Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases.Objective:Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triazole-4- Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity.Methods:In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of triazole Schiff’s bases. The active compounds were subjected to cytotoxicity analysis by MTT assay on mouse fibroblast (3T3) cell line. Molecular docking and simulation studies were carried out to evaluate the interactions and stability of compounds with HSA. Anti-hyperglycemic and antioxidant activities of selected non-cytotoxic compounds were evaluated by in vitro α-glucosidase inhibition, and DPPH free radical scavenging assays, respectively.Results:Compound 1 (IC50=47.30±0.38 µM) from 4H-1,2,4-triazole-4-Schiff’s bases has exhibited antiglycation activity comparable to standard rutin (IC50=54.5±0.05 µM) along with a stable RMSD profile in MD simulation studies. Compound 1 also exhibited a potent α-glucosidase inhibitory activity, and moderate antioxidant property. Other derivatives showed a weak antiglycation activity with IC50 values between 248.1-637.7 µM. Compounds with potential antiglycation profile were found to be non-cytotoxic in a cellular assay.Conclusion:The study identifies triazole Schiff’s bases active against fructose-mediated glycation of HSA, thus indicates their potential against late diabetic complications due to production of advancedend products (AGEs).
Analysis of Comparative Proteomic and Potent Targets of Peniciketal A in Human Acute Monocytic Leukemia
Authors: Gao Xue , Zhou Yuming , Sun Hongliu , Liu Desheng , Zhang Jing , Zhang Junru , Liu Weizhong , Pan Xiaohong 
Published: February 2019

Background:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control group on human acute monocytic leukemia cell line THP-1.Methods:The DEPs were analyzed by the liquid chromatography-tandem mass spectrometry (LC-MS/MS) with TMT label. The function and feature of the identified proteins were analyzed by the bioinformatic analysis. Western blotting was used to evaluate protein expression.Results:The DEPs were primarily sub located in the cytoplasm and the nucleus by regulating 21 pathways enriched through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Moreover, we preliminarily demonstrated that glucose-6-phosphate 1-dehydrogenase (G6PD), prolow-density lipoprotein receptor-related protein 1 (LRP1) and Calreticulin (CALR) might be the potent targets of Pe-A on death induction of THP-1 cells.Conclusion:Collectively, this study not only provides a global proteomic profile as the supplementary data of our previous studies but also provides interesting information that Pe-A may exert more bio-activities.
Impact of the Fontan Operation on Organ Systems
Authors: Michel Miriam , Zlamy Manuela , Entenmann Andreas , Pichler Karin , Scholl-Bürgi Sabine , Karall Daniela , Geiger Ralf , Salvador Christina , Niederwanger Christian , Ohuchi Hideo 
Published: February 2019

:
In patients having undergone the Fontan operation, besides the well discussed changes in
the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including
the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct
to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing
organ should allow for a better understanding of the pathomechanism underlying the typical
problems in Fontan patients, and in this context, the profiling of endocrinological and metabolic
patterns might offer a tool for the optimization of Fontan follow-up, targeted monitoring and
specific adjunct treatment.
Invasive Fungal Infection in Febrile Patients with Hematologic Malignancies Undergoing Chemotherapy in Iran
Authors: Sheikhbahaei Saba , Mohammadi Alireza , Sherkat Roya , Naeini Alireza Emami , Yaran Majid , Najafi Somaye 
Published: February 2019

Background:
Patients with hematological malignancies undergoing cytotoxic chemotherapy
are susceptible to develop invasive fungal infections particularly Aspergillus and Candida spp. Early
detection of these infections is required to start immediate antifungal therapy and increase the survival
of these patients.

Method:
Our study included consecutive patients of any age with hematologic malignancies who were
hospitalized to receive chemotherapy and suffer from persistent fever (rectal temperature >38.5°C) for
more than 5 days despite receiving broad-spectrum antibiotics. A whole blood sample was taken and
sent for blood culture. PCR was also conducted for Aspergillus and Candida species.

Results:
One hundred and two patients were investigated according to the inclusion criteria. The most
common hematologic malignancy was AML affecting 38 patients (37.2%). Six patients were diagnosed
with invasive fungal infections (A. fumigatus n=3, C. albicans n=2, A. flavus n=1) by PCR
(5.8%) while blood culture showed fungus only in 1 patient. Three more cases were known as probable
IFI since they responded to antifungal therapy but the PCR result was negative for them. AML was the
most prevalent malignancy in IFI patients (83.3%) and odds ratio for severing neutropenia was 21.5.
Odds for each of the baseline characteristics of patients including gender, age>60, diabetes mellitus,
previous IFI, history of using more than 3 antibiotics, antifungal prophylaxis, episodes of chemotherapy>
8 and chemotherapy regimen of daunarubicin+cytarabine were calculated.

Conclusion:
We found that multiplex real-time PCR assay is more accurate than blood culture in detecting
fungal species and the results are prepared sooner. Among all factors, the only type of cancer
(AML) and severe neutropenia, were found to be risk factors for the development of fungal infections
in all hematologic cancer patients and previous IFI was a risk factor only AML patients.
Development of Eco-Magnesium Based Composite with Enhanced Mechanical, Damping and Ignition Properties
Authors: Parande Gururaj , Gupta Manoj , Manakari Vyasaraj , Kopparthy Sripathi D.S. 
Published: February 2019

Background:
Magnesium alloys and nanocomposites have been of great importance to automotive,
aerospace and marine industries owing to their superior specific mechanical properties, impact
resistance, superior damping capacities, and biocompatibility. Low-cost manufacturing of magnesium-
based materials is the key to realize the high impact. We reviewed patents relating to production
of magnesium- based materials using low cost techniques.

Objective:
Recent trends in the field of magnesium technology has driven researchers to develop magnesium
materials applicable in both structural and biomedical applications. Incorporation of biocompatible
secondary reinforcements into the magnesium matrix is important to meet the current requirements.

Methods:
In the current study, low cost naturally available eggshell particles are reinforced into magnesium-
zinc alloy using powder metallurgy technique assisted microwave sintering technique and
tested for a mechanical, thermal and damping response.

Results:
Addition of eggshell improved the grain size of the Mg2.5Zn alloy by ~60%. The microhardness
values of Mg2.5Zn10ES composite is 73 Hv which is a significant 30% improvement when
compared to Mg2.5Zn alloy (56 Hv). Enhanced thermal stability was observed with the presence of
eggshell as Mg2.5Zn10ES composite did not self-ignite even at a temperature of 750°C. The compressive
yield strength of the composite was ~25% greater than the alloy owing to superior grain refinement
of ~60%.

Conclusion:
The presence of eggshell particles assisted in refining the microstructure, thereby significantly
enhancing the compression properties of the Mg-2.5Zn alloy and led to a better thermal and
dimensional stability of the synthesized composites. Structure-property correlations are drawn to understand
the behavior of the composites.
Cluster and Outlier Analysis for Ground Water Quality Data in the Regions of Kadapa District in Andhra Pradesh
Authors: Devi S.V.S. Ganga 
Published: February 2019

Background:
Patents suggest that groundwater contaminated with chemicals, bacteria,
oils or gases etc. leads to many types of diseases in people. Fresh and clean water plays a significant
role in human life. In this study, water samples were collected from different regions of the
Kadapa district, Andhra Pradesh.

Methods:
Water samples were collected in plastic bottles with a tight cap washed with distilled water.
Totally, 57 samples were collected and analyzed in the laboratory for physicochemical properties
like EC (Electrical Conductivity), pH, TH (Total Hardness), Total Dissolved Solids (TDS),Ca,
Cl and F. In this paper, K-means clustering, K-Mediods clustering and Hierarchical clustering
methods are used to group the collected regions of water samples based on the water quality. Later
outlier analysis was carried out and various interesting patterns were identified.

Results:
According to the WQI values calculated, all the collected samples were suitable for drinking
purpose. According to WQI values calculation, for the collected water sample data, it contained
13 poor tuples, 13 good tuples and 31 excellent tuples. According to K-means clustering, 3 clusters
were observed with sizes 8, 17, 32. According to Outlier analysis, the samples from region Pullareddypet
(sample No. 7) had the highest EC, TH and TDS values among the 57 collected water
samples. The samples from region Veerapalli (Sample No. 37) had the highest fluoride value 3.58
among all 57 samples collected.

Conclusion:
Unsupervised learning methods such as K-Means Clustering, K-Mediods clustering
and Hierarchical clustering methods are described for collecting data regarding the collected water
samples’ physico-chemical parameters. The cluster analysis results were compared with WQI values
calculated. The three clusters overlapped with each other with a small degree. In the study area,
for drinking purpose, only excellent, good, poor category tuples were found. Later, outlier analysis
has been described using Box plot method and K-means clustering method. By using outlier analysis
using K-means clustering, various interesting hidden patterns from the data were extracted.
A Human Memory Process Modeling
Authors: Shrivastava Rahul , Kumar Prabhat , Tripathi Sudhakar 
Published: February 2019

Background:
The cognitive models based agents proposed in the existing patents are not
able to create knowledge by themselves. They also did not have the inference mechanism to take
decisions and perform planning in novel situations.

Objective:
This patent proposes a method to mimic the human memory process for decision
making.

Methods:
The proposed model simulates the functionality of episodic, semantic and procedural
memory along with their interaction system. The sensory information activates the activity nodes
which is a binding of concept and the sensory values. These activated activity nodes are captured by
the episodic memory in the form of an event node. Each activity node has some participation
strength in each event depending upon its involvement among other events. Recalling of events and
frequent usage of some coactive activity nodes constitute the semantic knowledge in the form of
associations between the activity nodes. The model also learns the actions in context to the activity
nodes by using reinforcement learning. The proposed model uses an energy-based inference mechanism
for planning and decision making.

Results:
The proposed model is validated by deploying it in a virtual war game agent and analysing
the results. The obtained results show that the proposed model is significantly associated with all the
biological findings and theories related to memories.

Conclusion:
The implementation of this model allows humanoid and game agents to take decisions
and perform planning in novel situations.
A Low Power - High Speed CNTFETs Based Full Adder Cell With Overflow Detection
Authors: Saini Jitendra Kumar , Srinivasulu Avireni , Kumawat Renu 
Published: February 2019

The transformation from the development of enabling technology to mass production of
consumer-centric semiconductor products has empowered the designers to consider characteristics like
robustness, compactness, efficiency, and scalability of the product as implicit pre-cursors. The Carbon
Nanotube Field Effect Transistor (CNFET) is the present day technology. In this manuscript, we have
used CNFET as the enabling technology to design a 1-bit Full Adder (1b-FA16) with overflow detection.
The proposed 1b-FA16 is designed using 16 transistors. Finally, the proposed 1b-FA16 is further
used to design a Ripple Carry Adder (RCA), Carry Look Ahead Adder (CLA) circuit and RCA with
overflow bit detection.

Methods and Results:
The proposed 1b-FA16 circuit was designed with CNFET technology simulated
at 32 nm with a voltage supply of +0.9 V using the Cadence Virtuoso CAD tool. The model used is
Stanford PTM. Comparison of the existing full adder designs with the proposed 1b-FA16 design was
done to validate the improvements in terms of power, delay and Power Delay Product (PDP). Table 2,
shows the results of comparison for the proposed 1b-FA16 with the existing full adder designs implemented
using CNFET for parameters like power, delay and power delay product.

Conclusion:
It can be concluded that the proposed 1b-FA16 yielded better results as compared to the
existing full adder designs implemented using CNFET. The improvement in power, delay and power
delay product was approximately 11%, 9% and 24% respectively. Hence, the proposed circuit implemented
using CNFET gives a substantial rate of improvements over the existing circuits.
Flora melífera de la región centro-este del municipio de Pátzcuaro, Michoacán, México
Authors: Araujo-Mondragón Fernando , Redonda-Martínez Rosario 
Published: February 2019

Antecedentes y Objetivos: Las plantas melíferas son aquellas que, principalmente, producen néctar y polen, aunque también son consideradas en esta categoría las que generan propóleos. Los apicultores, antes de instalar un apiario, necesitan conocer la flora melífera de una región, pues de ella depende la producción de miel. El objetivo de este trabajo fue identificar las plantas melíferas que crecen en la región centro-este del municipio Pátzcuaro, Michoacán, México.Métodos: Se realizó trabajo de campo en zonas aledañas a cuatro apiarios de referencia, es decir, un kilómetro de radio, tomando como punto de referencia cada uno de los apiarios ubicados en la región centro-este del municipio Pátzcuaro. Se observaron las preferencias de alimentación y recolección de polen de Apis mellifera, se colectaron ejemplares de las plantas que utiliza y se documentaron sus visitas mediante fotografías. Finalmente, se tomaron muestras de miel en dos épocas del año, una antes del pico de floración de las especies melíferas de la zona y otra en la temporada de cosecha de miel, con la finalidad de realizar estudios melisopalinológicos para identificar los tipos polínicos presentes en la miel.Resultados clave: Se identificaron 93 especies de plantas melíferas, pertenecientes a 33 familias botánicas; Asteraceae es la más representativa. En los análisis melisopalinológicos se observó un promedio de 16 tipos polínicos por muestra; el polen de compuestas fue el más abundante.Conclusiones: La flora melífera de la región estudiada se ha visto afectada por su erradicación, debido a que la mayoría de las especies son malezas, al cambio de uso de suelo, para instalar principalmente huertas de aguacate, y por las plagas de chapulines que defolian las plantas provocando retraso o ausencia de floración.
Effect of Family Strength over the Psychological Well-being and Internal Locus of Control.
Authors: García-Cadena Cirilo Humberto Humberto , Moral de la Rubia José Moral de la Rubia , Díaz Díaz Héctor Luis , Martínez Rodríguez Juan , Sánchez Reyes Lorenzo , López Rosales Fuensanta 
Published: February 2019

If the development of the concept of “self” as a unit distinct from the environment ontogenetically follows the development of the concept of “us”, then psychosocial constructs would play a very important role in explaining psychological constructs. The current study explores to what extent the psychosocial construct “family strength” can be used to predict the psychological constructs “psychological well-being” and “internal locus of control”. Three different scales were administered to a non-probability sample of 400 subjects (153 males and 247 females) to measure family strength, psychological well-being and internal locus of control. Structural Equation Models found that 67% of the variance in psychological well-being and 59% of the variance in internal locus of control were predicted by “family commitment-trust” with good data adjustment (χ2/df = 1.78, GFI = .95, AGFI = .94, and NFI = .92). These findings show the primacy of the psychosocial dimension over the psychological dimension. The article discusses the implications of these findings for professional healthcare practice.
A Challenging Case of Non-resolving Pneumonia: Keeping Antisynthetase Syndrome In the Differential Diagnosis
Authors: Lapinsky Stephanie , Leen Jessica , Mak Jessica , Shafiee Mohammed A. 
Published: February 2019

A 62-year-old Caucasian female ex-smoker presented to the emergency department with progressive shortness of breath with associated pleuritic chest pain, new arthralgias, and muscle weakness for two months. She had already been treated with two courses of antibiotics for suspected community acquired pneumonia (CAP) with no improvement in her respiratory symptoms. This is a case that illustrates the eventual diagnosis of antisynthetase syndrome, a subtype of the idiopathic inflammatory myopathies. Current standard of diagnostic criteria and treatment for this autoimmune condition will also be discussed.
Liver Abscess Metastatic Syndrome Caused by Hypermucoviscous Klebsiella Pneumoniae in a Canadian Patient of Vietnamese Origin
Authors: Criales Doria Sandra Patricia , Lafleur Alexandre , Gervais Philippe 
Published: February 2019

Klebsiella pneumoniae liver abscess syndrome (KLAS) is an emerging infection caused by hypermucoviscous strains (K1, rmpA, mgA) with a particular virulence at risk of metastatic dissemination. We describe a case of metastatic KLAS in a Canadian immunocompetent patient of Vietnamese origin who presented with fever and abnormal liver function tests. Imaging studies revealed unique liver and pulmonary abscesses. Blood and liver abscess cultures showed colonies of K.pneumoniae with hypermucoviscous phenotype, a K1 serotype and the presence of a rmpA gene confirming biomolecular features of the invasive syndrome. Mostly reported in patients of Asian origin, KLAS has been reported in Canada since 2007. Prompt identification and treatment prevents severe complications such as endophthalmitis, meningitis, lung abscess and spondylodiscitis. Résumé:Le syndrome d’abcès hépatique à Klebsiella pneumoniae (KLAS en anglais) est une infection en émergence résultant d’une souche hypermuqueuse (K1, rmpA, mgA) d’une virulence accrue, à risque de dissémination. Nous décrivons un cas de KLAS métastatique chez un patient canadien d’origine vietnamienne, immunocompétent, qui présentait de la fièvre et des anomalies du bilan hépatique. Les imageries ont révélé des abcès hépatiques et pulmonaires uniques. Les hémocultures et les cultures du drainage de l’abcès hépatique ont confirmé la présence d’une souche hypermuqueuse de Klebsiella pneumoniae, sérotype K1, génotype rmpA, caractéristiques biomoléculaires associées aux infections invasives. Principalement décrits chez des patients d’origine asiatique, des cas de KLAS sont rapportés au Canada depuis 2007. L’identification et le traitement rapide préviendront des complications sévères, dont l’endophtalmite, la méningite, l’abcès pulmonaire et la spondylodiscite.
Salud y bienestar psicológico: Violencia intrafamiliar y su influencia en la autoestima de los escolares
Authors: Zambrano Villalba Carmen Graciela 
Published: February 2019

Resumen La Psicología clínica y de la salud permite ampliar el marco de la investigación desde las escalas de salud y bienestar psicológico, el mismo que es un estado afectivo positivo que favorece el desarrollo integral y pleno de la personalidad y del estilo de vida saludable. La violencia intrafamiliar es un tipo de violencia relacional que afecta directamente en el desarrollo psicológico, e integral de los escolares. La niñez y adolescencia es una etapa de vulnerabilidad que sumado a la incidencia de la violencia en el sistema familiar, afecta significativamente en la formación del autoestima, autoconcepto y desarrollo integral de la personalidad. La autoestima es el aprecio, consideración que uno tiene de sí mismo, se forma por la percepción, pensamientos y sentimientos que surgen en el contacto relacional en el sistema familiar, escolar y social. En este artículo se indaga como influye la violencia intrafamiliar en la autoestima de los escolares de 10 a 14 años tomando en consideración subvariables de cohesión, expresividad, conflicto, apoyo, confianza, comunicación, indicadores que influyen en el desarrollo de la autoestima de los niños y niñas expuestos a violencia intrafamiliar. Se utiliza el cuestionarios de clima familiar y de autoestima que permiten obtener información relevante para el estudio. La muestra esta constituida por 13776 escolares de séptimo, octavo y noveno año de EGB. Los resultados afirman que la violencia intrafamiliar influye directamente en el nivel de autoestima de los niños y niñas en la etapa escolar con prevalencia de edad, genero y nivel de escolaridad. Palabras clavesBienestar psicológico, Violencia, Autoestima