bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verification of compressibility and consolidation parameters of varved clays from Radzymin (Central Poland) based on direct observations of settlements of road embankment
Authors: Dobak Paweł , Kiełbasiński Kamil , Szczepański Tomasz , Zawrzykraj Piotr 
Published: January 2019

Abstract
Formation of varved clays is characterized by specific compressibility and consolidation features, which are difficult to assess. The construction of an expressway through the area of varved, glacilimnic sediments (Vistula glacial period) required careful analysis of the soil reaction to the increasing load caused by growing embankment. The settlement analyses conducted in relation to the schedule of load increase during construction allowed to verify the deformability assessment of the compressible clays. In order to quantify the compressibility and consolidation parameters of clays, an iterative calculation model was created. The method of the “inverse solution” was used to define optimized values of deformability parameters. The observed delayed reaction of the soil to applied load allowed to assess the nature of consolidation. Comparison of the parameters obtained from the model with the results of laboratory and field tests allowed to evaluate drainage characteristics during consolidation of varved clays as well as to introduce correlation coefficients for interpreting compressibility parameters on the basis of CPT tests.
Combination of novoseven and feiba in hemophiliac patients with inhibitors
Authors: Malkan Umit Yavuz , Aksu Salih 
Published: January 2019

Abstract
The aim of this study is to investigate the effective therapeutic combination of recombinant VIIa(Novoseven) and factor eight inhibitor bypass activity(FEIBA) drugs for the bleedings of adult hemophiliac patients with inhibitors.19 bleeding episodes of 5 hemophilia A patients who were using bypassing agents and followed-up between 2008 and 2016 in Hacettepe Hematology Department were analyzed retrospectively. In 11, 5 and 3 bleeding episodes, FEIBA, recombinant factor VIIa and FEIBA+recombinant factor VIIa were given to the patients, respectively. The treatment durations differed between 1 and 14 days depending on the bleeding and clinical course of the patients. Generally the treatment with bypassing agents was successful, and only in one patient who had elbow hematoma encountered serious bleeding which was taken under control by switching the bypass agent. We offer a different approach because of three reasons. Firstly, in our protocol we start the treatment with recombinant factor VIIa for the first three days. Secondly, our protocol is adjusted to consider health economics. Thirdly, we extended the time interval between doses of both bypassing agents without increasing bleeding risks because the half-life of both agents enables us to modify the protocol with more flexibility. To conclude, we have evaluated our clinic’s data about hemophilia A patients with inhibitors and we offer a different protocol in the management of bleeding episodes for these patients.
Caracterización fermentativa y nutricional de mezclas ensiladas de corona de piña con guineo cuadrado Musa (ABB) I. Parámetros fermentativos, análisis bromatológico y digestibilidad in vitro.
Authors: Lazo-Salas Gerson J. , Rojas-Bourrillon Augusto , Campos-Granados Carlos M. , Zumbado-Ramírez Carlos , López –Herrera Michael 
Published: January 2019

Esta investigación se realizó con el objetivo de determinar y analizar las características bromatológicas, fermentativas y potencial digestivo de ensilados de corona de piña con cuatro niveles de sustitución de guineo cuadrado Musa (ABB). Se utilizó un diseño irrestricto al azar con 4 tratamientos de mezclas en base fresca de corona de piña y guineo cuadrado inmaduro en relación 100:0 85:15, 70:30 y 55:45 con cinco repeticiones por tratamiento. A las mezclas se les adicionó un 1% de melaza y se fermentaron durante 70días. No se utilizó inóculo bacterial. Se utilizaron silo bolsas de 50kg para el almacenamiento del material. Se cuantificó un aumento significativo (p<0,05) en los contenidos de materia seca, digestibilidad in vitro de la materia seca, pectinas, carbohidratos no fibrosos en los ensilajes conforme se aumentó el nivel de sustitución de guineo cuadrado en la mezcla. Los contenidos de proteína cruda, cenizas y ácido acético, ácido propiónico, disminuyeron significativamente (p<0,05) conforme se aumentó el nivel de sustitución de guineo cuadrado. No se encontraron diferencias significativas (p<0,05) para los contenidos de nitrógeno amoniacal, ácido butírico, ácido láctico, extracto etéreo ni para el pH entre las cuatro mezclas evaluadas. Se concluye que mezclas de la corona de piña (70%) con el guineo cuadrado (30%) Musa (ABB) se preservan mediante el proceso del ensilaje y representa una opción el mejoramiento nutricional de la corona en la alimentación de rumiantes. Se recomienda aumentar los niveles de inclusión de melaza para promover una mejor fermentación del ensilaje.
Kiégés és reziliencia (rugalmas ellenállás) a magyarországi orvosok körében
Authors: Győrffy Zsuzsa 
Published: January 2019

Abstract: Introduction: The burnout of healthcare workers is of outstanding significance in both national and international studies. Aim: Based on a representative, national physician survey (n = 5013), the aim of this study was to describe burnout indicators and the correspondence between them and working conditions. Moreover, we were aiming to compare the results with our 2013 physician survey and to analyze the potential relationship between burnout and resilience. Method: We analyzed the results of the online quantitative survey with multiple variables descriptively. The connection between the respective dimensions of burnout and resilience was studied with logistic regression. Results: In comparison with data from 2013, the medium and high level proportions of depersonalization and personal accomplishment were similar (49% versus 49.9% and 65.1% versus 68.9%). Since 2013 (49%), we experienced a decrease in depersonalization (40.2%). Those working in in-patient care, at multiple workplaces and shift hours regularly have a higher chance of burnout. Our multivariable analysis has shown that the lack of resilience is an important predictor for the medium and high levels of emotional exhaustion, depersonalization and personal accomplishment. Conclusion: Our results have shown that internal resources, coping strategies and resilience play a key role in burnout and its decrease. Orv Hetil. 2018; 160(3): 112–119.
Transport and Electromechanical Properties of Ca3TaGa3Si2O14 Piezoelectric Crystals at Extreme Temperatures
Authors: Suhak Yuriy , Johnson Ward L. , Sotnikov Andrei , Schmidt Hagen , Fritze Holger 
Published: January 2019

AbstractTransport mechanisms in structurally ordered piezoelectric Ca3TaGa3Si2O14 (CTGS) single crystals are studied in the temperature range of 1000-1300 °C by application of the isotope 18O as a tracer and subsequent analysis of diffusion profiles of this isotope using secondary ion mass spectrometry (SIMS). Determined oxygen self-diffusion coefficients enable calculation of oxygen ion contribution to the total conductivity, which is shown to be small. Since very low contributions of the cations have to be expected, the total conductivity must be dominated by electron transport. Ion and electron conductivities are governed by different mechanisms with activation energies (1.9±0.1) eV and (1.2±0.07) eV, respectively. Further, the electromechanical losses are studied as a function of temperature by means of impedance spectroscopy on samples with electrodes and a contactless tone-burst excitation technique. At temperatures above 650 °C the conductivity-related losses are dominant. Finally, the operation of CTGS resonators is demonstrated at cryogenic temperatures and materials piezoelectric strain constants are determined from 4.2 K to room temperature.
Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells
Authors: Yoshimura Yasuhiro , Taguchi Atsuhiro , Tanigawa Shunsuke , Yatsuda Junji , Kamba Tomomi , Takahashi Satoru , Kurihara Hidetake , Mukoyama Masashi , Nishinakamura Ryuichi 
Published: January 2019

Significance StatementRecent progress in stem cell biology has enabled researchers to induce nephron progenitor cells (NPCs) and kidney organoids from pluripotent stem cells (PSCs). However, shepherding NPC differentiation toward a specific nephron segment remains a challenge. The authors observed the effects of various growth factors in cultured mouse embryonic NPCs during three phases of the differentiation process, demonstrating that phase-specific manipulation of Wnt and Tgf-βsignaling is critical for podocyte differentiation. Using this insight into the nephron-patterning process, they were able to selectively induce human PSC-derived podocytes with molecular, morphologic, and functional characteristics of human podocytes. This novel protocol will facilitate accessibility to human podocytes, and these PSC-derived podocytes are expected to serve as a valuable resource in kidney research.BackgroundPrevious research has elucidated the signals required to induce nephron progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of kidney organoids. However, selectively controlling differentiation of NPCs to podocytes has been a challenge.MethodsWe investigated the effects of various growth factors in cultured mouse embryonic NPCs during three distinct steps of nephron patterning: from NPC to pretubular aggregate, from the latter to epithelial renal vesicle (RV), and from RV to podocyte. We then applied the findings to human PSC-derived NPCs to establish a method for selective induction of human podocytes.ResultsMouse NPC differentiation experiments revealed that phase-specific manipulation of Wnt and Tgf-βsignaling is critical for podocyte differentiation. First, optimal timing and intensity of Wnt signaling were essential for mesenchymal-to-epithelial transition and podocyte differentiation. Then, inhibition of Tgf-βsignaling supported domination of the RV proximal domain. Inhibition of Tgf-βsignaling in the third phase enriched the podocyte fraction by suppressing development of other nephron lineages. The resultant protocol enabled successful induction of human podocytes from PSCs with >90% purity. The induced podocytes exhibited global gene expression signatures comparable to those of adult human podocytes, had podocyte morphologic features (including foot process–like and slit diaphragm–like structures), and showed functional responsiveness to drug-induced injury.ConclusionsElucidation of signals that induce podocytes during the nephron-patterning process enabled us to establish a highly efficient method for selective induction of human podocytes from PSCs. These PSC-derived podocytes show molecular, morphologic, and functional characteristics of podocytes, and offer a new resource for disease modeling and nephrotoxicity testing.
BİR ÜNİVERSİTE HASTANESİNDE ÇALIŞAN HEMŞİRELERİN ETİK İKLİM ALGISI
Authors: Türe Yılmaz Aysun , Yıldırım Aytolan 
Published: January 2019

Giriş:
Etik
ilkeler ve davranışlardan oluşan etik iklim, çalışanlardan örgüttün beklediği
davranışları gösterir. Bu davranışların çalışanlar tarafından kullanılma
sıklığı etik iklimin o derece kabul edildiğini ifade eder.

Amaç: Bu araştırma,
hemşirelerde etik iklim algısını ve bunları etkileyen sosyo demografik
özellikleri saptamak amacıyla yapılmıştır.

Yöntem: Bu tanımlayıcı çalışma
Eskişehir ilindeki bir üniversite hastanesinde çalışan 394 hemşire ile yürütülmüştür.
Araştırmanın verileri, araştırmacı tarafından oluşturulan Kişisel Bilgi Formu
ile 36 madde ve 3 alt boyuttan oluşan Etik İklim Ölçeği ile toplanmıştır

Bulgular: Araştırmaya
katılan hemşirelerin çoğunun kadın, bekar, lisans mezunu olduğu, yaş
ortalamalarının 29.43±6.50 olduğu, meslekte çalışma yılı ortalamasının 7.70±5.90
olduğu belirlenmiştir. Araştırmaya katılan hemşirelerin ölçek toplam puanının
ortalamanın üzerinde (123.24±20.77) olduğu belirlenmiştir. Alt boyut puan ortalamalarının
sırasıyla; yardımseverlik iklimi (42.26±9.03), ilkelilik iklimi (41.05±8.38) ve
egoist iklim (39.92±5.09) olarak dağılım gösterdiği saptanmıştır. Ölçek genel
ve alt boyut puan ortalamalarının demografik özelliklerle karşılaştırılmasında;
sadece eğitim durumu ve çalıştığı klinik değişkenleri aralarında istatistiksel
açıdan anlamlı bir farklılık olduğu saptanmış; diğer sosyo demografik
özellikler arasında istatistiksel açıdan anlamlı bir ilişkinin olmadığı
saptanmıştır.

Sonuç: Araştırmaya katılan hemşirelerin çalışma
ortamında etik iklime yönelik algılarının ortalamanın üzerinde olduğu
saptanmıştır.

Anahtar Kelimeler:
Hastane,
Hemşire, Etik İklim Algısı.
SOSYAL OLARAK İNŞA EDİLMİŞ MODERN ANNELİK SÖYLEMİ İÇERİSİNDE BİR ASMA KAT SÜTANNE GELENEĞİ
Authors: Güneş Hüseyin Nihat 
Published: January 2019

Toplumsal değişme ve toplumsal cinsiyet tartışmalarının, ilkel aile modelinin
anaerkil özellikler taşıdığı noktasında birleştiği söylenebilir. Ataerkil
rejime geçişin ise üretim ilişkilerinin yarattığı yeni işbölümü ile mümkün olduğu düşünülmektedir. Toplumsal cinsiyet
eşitsizliği açısından kadının konumu, ataerkil düzen içerisinde yeni katmanlar
oluşturarak bugünkü problemli çerçevesine ulaşmıştır. Bu dönüşüm süreci içinde
kadının bir anne olarak tanımlanma biçimleri de farklılıklar göstermiştir.
Tarihsel kayıtlar, annelik olgusunun günümüzdeki haliyle kutsiyet içeren anlamlar
taşımadığına dair ipuçları ile doludur. Annenin durumu, toplumsal sınıflarla
ilişkisi ölçüsünde avantaj ve dezavantajlar içerdiği kadar Ortaçağ Avrupası’nda olduğu gibi görev ve sorumluluk
çerçevesinin daha esnek olduğu genel bir algıya da işaret etmiştir. Bugün anne
olmanın en temel yükümlülüğü olarak görülen emzirme süreci, tarih boyunca
farklı alternatifler yoluyla hayat bulmuştur. Biberonla besleme, doğrudan bir
hayvanın memesinden besleme gibi farklı seçenekler oldukça eski çözümler olarak
karşımıza çıkarken bunlar arasında en bilineni sütannelik müessesesi olmuştur.
Sütanne geleneğinin, temel olarak annenin ölümü ya da yetersiz süt üretimini
ikame etmek üzere ortaya çıktığı tahmin edilse de bilinen birçok örnekte bu
müssesenin keyfi bir tercih olarak genellikle üst tabaka ailelerinde
kullanıldığı görülmektedir. Bu örneklerde sütannelik, süt ihtiyacını
karşılamanın yanı sıra bebek bakımı ve rehberliği şeklinde değerlendirilmiştir.
Ortaçağ Avrupası’nda ise soylu veya varlıklı
annelerin emzirmesinin ayıp karşılandığı ve bu ailelerin bebeklerinin doğar
doğmaz bir sütanneye gönderildiği gözlenmiştir. Söz konusu deneyimler,
günümüzde doğayla eş özelliklerle tanımlanan ve yerine getirdiği işlev
açısından kutsal görülen ve tüm bu özelliklerinin yine doğa tarafından verilmiş
annelik dürtüsüyle mümkün olduğunu ifade eden annelik söylemiyle uyumsuzluk
göstermektedir. O halde sütanne geleneğinin tarihte birçok benzer örneğinin
belgelendiği kullanım biçimleri münferit örnekleri mi yansıtmaktadır yoksa bu
örnekleri anomali olarak algılamamamıza
olanak veren çağdaş annelik söylemi yeniden mi değerlendirilmelidir?

Bu çalışma, annelik olgusunun tarihsel görünümlerinden ve sütannelik
geleneğinin tarihsel örneklerinden yola çıkarak 18.yüzyıldan başlayarak
etkisini giderek arttırmış olan modern annelik söyleminin temel saiklerini
tartışmayı amaçlamaktadır.
DIGITAL ECONOMY AND RECRUITMENT POTENTIAL: STRATEGICAL INTERCONNECTION AND PROSPECTS
Authors: Peshkova G. Yu. , Samarina А. Yu. 
Published: January 2019

Introduction.Nowadays, information technologies are developing rapidly. This process affects practically all spheres of life and causes the need of system technological revolutions and modern methods of data processing. A process of digitalisation inevitably changes the structure of population employment and the educational environment as being provider of new HR-recourses.Theaimsof the research were to identify the problems of the digitalization policy in Russia and to formulate possible solutions.Methodology and research methods.The methods of theoretical investigation were used: abstraction, synthesis, analysis and generalisation.Results.The interaction of education systems and science in the field of preparation of HR-recourses at the stage of digital modernisation of the Russian economy is considered. The impact of digitalisation on vacancies and competences needed and the level of preparedness of Russia for the new technological mode are analysed. The perspective directions of higher education and recruitment policy of enterprise and the whole state are identified. The authors have come to the conclusion that rational recruitment policy is an essential part of Russian economy’s digitalisation. The efficiency of realisation of this strategy requires systembased approach to the organisation of staff training for the enterprises in actively changing economic conditions. HR management has become an extremely important element of this system. It is impossible to manage with such digitalization risks as structural unemployment and – at the same time – deficit of highly-qualified specialists without paying attention to what HR-market requires.Scientific novelty. The originality of digital economy is in its optimising effect on production and consumption possible because of operativeness and consolidation of information and computing systems. There has appeared an opportunity to manage socio-economic processes systematically. The necessity of structural changes in HR-market is proved. Moreover, high schools should head the process of overcoming the expected structural unemployment caused by new technologies appearing, i.e. they provide high-quality education of specialised competencies necessary for workers, in particular. Universities must not wait for the government to work out and present new standards and recommendations. On the contrary, high schools ought to independently and urgently initiate the organisation of competitive experts training and to form innovative methods of education of new specialists by cooperating with business sphere and taking examples of digital leaders. To sum up, sensible approach to educational policy can solve the problem of balancing the HК-market and prevent social disturbance.Practical significance.On the example of activity of separate higher education institutions, the ways and models of functioning of the higher school are shown according to economic tendencies.
Anthropometric Features of Ethnic Kyrgyz of Different Age Groups
Authors: Sakibaev K. Sh. , Alexeeva N. T. , Nikityuk D. B. , Tashmatova N. M. , Klochkova S. V. 
Published: January 2019

The purposeof this study was to develop data about growth-weighted indexes of men of youthful and Mature age, ethnic Kyrgyz.Material and methods. 955 men of youthful and Mature age, ethnic Kyrgyz living in Osh and its vicinities, practically healthy were examined. The method of complex anthropometry included estimation of 21 parameters necessary for somatotyping. The length and weight of the body were determined. Morphometric data processing was carried out with the help of statistical programs Microsoft Excel and STATISTICA 6.0 package. The differences between the two compared values were considered reliable according to the student's criterion at p < 0.05.Results. Somatotyping of men showed predominance of abdominal somatotype, with a minimum percentage of breast somatotype. The analysis of growth-weight indicators in different somatotypes showed that regardless of the somatotype, the length of the body increases slightly during the transition from adolescence to the 1st period of adulthood, which is explained by the continuation of growth processes. A slight decrease in body length in the 2nd period of adulthood is due to natural physiological processes and is a proven age-dependent fact.Conclusion. In the result of the study shows the distribution in the relative number of different somatotypes of men in the Kyrgyz population; shows the age and somatotypological characteristics of height and body mass that has significant scientific and practical importance.
PROTEIN ADHESI SUB UNIT PILI Shigella flexneri 18 kDa MENINGKATKAN EKSPRESI PROTEIN ANTIMIKROBA  DEFENSIN PADA MENCIT ( STRATEGI PENGEMBANGAN VAKSIN SHIGELLOSIS BERBASIS PROTEIN ADHESI)
Authors: Fitrianingsih Avin Ainur , Rachma Lailia Nur , Milliana Alvi 
Published: January 2019

<p><em>Shigellosis</em> merupakan penyakit endemis yang terutama terjadi di negara berkembang dan merupakan penyebab tersering penyakit diare yang berdarah. Pengembangan vaksin dari molekul adhesin memiliki kelebihan pada reaksi imun tubuh yang terbentuk akan membentuk sistem pertahanan tubuh yang lebih kuat dalam mengeliminasi bakteri serta tidak menimbulkan panas seperti vaksin dari sel utuh bakteri atau dari LPS-nya. Berdasarkan penelitian sebelumnya diketahui bahwa pili <em>Shigella flexneri</em> dengan Berat Molekul (BM) 18 kDa merupakan molekul adhesi serta mampu bereaksi silang dengan pili Shigella spesies lainnya. Penelitian ini dimulai dengan proses isolasi pili <em>S. flexneri</em>, kemudian dilanjutkan dengan profiling pili dengan cara elektroforesis SDS-PAGE. Kemudian dilakukan perbanyakan protein sub unit pili dengan elektroelusi. Protein sub unit yang sudah diperoleh kemudian diimunisasikan ke mencit Balb/c secara peroral menggunakan sonde, dengan pemberian 4 kali selang 1 minggu, dan pada akhir minggu ke 4 mencit dimatikan. Serum, mukosa usus dan paru mencit yang didapatkan kemudian diuji kadar <em>Antimicrobial peptide </em>β defensin dengan metode ELISA. Kesimpulan penelitian ini adalah pemberian protein adhesi sub unit pili <em>S. flexneri</em> 18 kDa selama 4 minggu mampu meningkatkan kadar <em>Antimicrobial peptide β defensin </em>pada serum, mukosa usus, dan paru mencit.<em> </em>Sehingga protein adhesi sub unit pili <em>S. flexneri</em> 18 kDa berpotensi menjadi vaksin berbasis sub unit protein adhesi untuk kasus Shigellosis.</p><p><strong>Kata Kunci</strong> : <em>Shigella flexneri</em>, sub unit pili 18 kDa, <em>Antimicrobial peptide β defensin</em></p><p> </p>
Mengembangkan Pemikiran Falsafah Pendidikan Islam
Authors: Fahruddin Mukhlis 
Published: January 2019

<span><em>Dichotomic paradigm in Islamic education has brought about some </em><span><em>difficulties in responding challenges of change. This dichotomic prototype </em><span><em>even caused the backthrough of Islamic civilization. In spite of this, new </em><span><em>paradigm of Islamic scientific epistemology which develop integratic and</em><br /><span><em>interconected Islamic educational progress in the future is needed. The </em><span><em>progress thoughts is needed in Islamic education to minimize disparity </em><span><em>between science and religion.</em><br /><span><strong>keywords: </strong><span><em>Epistemology, Philosophy, Development and Islamic</em><br /><span><em>education</em></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span>