bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL RATS
Authors: YADAV A. V. , UPASANI C. D. 
Published: April 2019

Objective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Plumeria rubra (HAEPR) against cisplatin-induced nephrotoxicity in Wistar rats.
Methods: HAEPR was administered orally at 3 dose levels (100,200,400 mg/kg). Vitamin E (250 mg/kg) was used as a Standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, blood urea nitrogen) oxidative stress study (estimation of superoxide dismutase, malondialdehyde activity) and histological examination of kidneys was conducted.
Results: The efficacy of HAEPR was compared with Cisplatin (CP) treated group. Serum creatinine and BUN was significantly (p<0.01) elevated in CP-treated group compared to the control group. HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) decreased the serum creatinine and BUN levels. CP treated group exhibited significant (p<0.01) decrease in albumin when compared to control. Significant (p<0.01) increase in the serum albumin level was found in HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) compared to CP group. Significant (p<0.01) decrease in the activity of SOD was observed in the CP group as compared to control. HAEPR (100 and 200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) increased SOD levels. HAEPR (400 mg/kg) significantly (p<0.05) increased SOD levels. HAEPR (100,200,400 mg/kg) significantly (p<0.01) decreased MDA levels as compared to CP group. Histopathological examination of the kidneys showed that HAEPR markedly ameliorated Cisplatin-induced renal tubular necrosis. An extract was found effective at all doses, although low dose (100 mg/kg) was found to be more effective and comparable with the standard group (Vitamin E 250 mg/kg).
Conclusion: Present investigation revealed that HAEPR resulted in attenuation of Cisplatin-induced renal damage in rats.
DESIGN, DOCKING AND SYNTHESIS OF NOVEL BROMO ISATIN INCORPORATED ISOXAZOLE DERIVATIVES AS VEGFR-2 INHIBITORS
Authors: T. RADHIKA , K. SAISREE , V. HARINADHA BABU 
Published: April 2019

Objective: To design, synthesize, in vitro Vascular Endothelial Growth Factor Receptor (VEGFR-2) assay, antiproliferative activity an Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) studies of some novel bromoisatin incorporated isoxazole derivatives.
Methods: Designed compounds were synthesized by the condensation of different 3-aryl-5-methylisoxazole-4-carbohydrazides (5a-h) with 5-bromoisatin to give the target molecules. To predict the affinity and activity of the ligand molecule the docking program GOLD 3.1 was employed to generate different bioactive binding poses of designing molecules at the active site of protein VEGFR-2. All the synthesized compounds were characterized based on the spectral and elemental analysis data. Antiproliferative activity performed against Human Umbilical vein endothelial cells (HUVEC cell line).
Results: All the synthesized compounds showed the characteristic peaks in FTIR,1H, C[13]NMR and Mass spectral analysis. In molecular docking, all the synthesized compounds (6a-j) exhibited high fitness scores with minimum three bonding interaction with the active site VEGFR-2 kinase. In in-vitro, VEGFR-2 kinase assay, compounds 6a, 6b, 6d and 6e exhibited more than 70% inhibition at a single dose concentration of 5μM. In antiproliferative assay against HUVEC cell lines, compounds 6d and 6e exhibited potent activity with IC50 values in nanomolar concentrations. ADMET results of 6a, 6b, 6d and 6e are quite promising with least hepatotoxicity and good bioavailability.
Conclusion: The derivatives were synthesized in quantitative yields. New derivatives posses antiproliferative activity, least hepatotoxicity and good bioavailability.
SPONDYLODISCITIS DIAGNOSTICS IN NOWADAYS: BASIC CT AND MRI SIGNS
Authors: Vinokurov A. S. , Belenkaya O. I. , Yudin A. L. , Kim A. V. 
Published: April 2019

For many reasons spondylodiscitis (SDC) is a complicated pathology. It is caused by difficulty in early diagnostics, the need for surgical treatment (including repeated interventions), long term and high cost of antibiotic therapy. Objective. The goal is to identify and describe the main CT and MRI symptoms of SDC, to assess their frequency and specificity. The next aim is to note the peculiarities of the radiologist’s practice with such patients. Materials and methods. We studied the data of 25 patients with proved SDC, and we analyzed CT and MRI symptoms (both common and rare), and the role of contrast enhancement (СE) in both methods and important clinical and laboratory aspects. Results.The infiltration of vertebral bodies and intervertebral discs were the most frequent SDC signs, abscesses also were very common. The most significant type of abscess was epidural which led to the formation of vertebral canal stenosis and to neurological deficit. The important methodological aspects of the MRI study were noted to improve its quality. Conclusion. We recommend performing both CT and MRI, if possible, for all patients with SDC because of the different diagnostic tasks that are important for clinicians.CE significantly increases the MRI informativity.
Diabetes-Related Complications and Mortality in Patients With Young-Onset Latent Autoimmune Diabetes: A 14-Year Analysis of the Prospective Hong Kong Diabetes Register
Authors: Luk Andrea O.Y. , Lau Eric S.H. , Lim Cadmon , Kong Alice P.S. , Chow Elaine , Ma Ronald C.W. , Chan Juliana C.N. 
Published: April 2019

OBJECTIVE
Young-onset diabetes is heterogeneous in etiology and disease progression. We compared the incidence of diabetes-related complications and mortality in patients with young-onset type 2 diabetes with or without anti-GAD antibodies and patients with type 1 diabetes. We determined changes in glycemic control before and after commencement of insulin therapy stratified by antibody status.

RESEARCH DESIGN AND METHODS
Between 1994 and 2012, 1,504 consecutively enrolled patients with type 2 diabetes who had received a diagnosis at &lt;40 years of age and had available anti-GAD antibody status and 251 patients with type 1 diabetes from the Hong Kong Diabetes Register were followed for incident cardiovascular disease (CVD), end-stage renal disease (ESRD), severe hypoglycemia, and all-cause mortality until June 2015. Information on insulin use and HbA1c levels during follow-up was obtained.

RESULTS
Anti-GAD antibodies were positive in 8.1% of patients with type 2 diabetes (GAD+). By multivariate Cox regression, patients with GAD+ had a lower hazard of CVD (hazard ratio [HR] 0.43, P = 0.048), a higher hazard of severe hypoglycemia (HR 1.63, P = 0.032), and a similar hazard of ESRD and mortality compared with counterparts without anti-GAD antibodies (GAD−). Compared with patients with type 1 diabetes, ESRD was more likely to develop (HR 2.91, P = 0.043) in patients with GAD+, but no differences were detected in the hazards of severe hypoglycemia, CVD, and mortality. Among new insulin users (n = 304), patients with GAD+ had larger reductions in HbA1c than patients with GAD−after 12 months of insulin use (−2.30 ± 3.80% [25 ± 42 mmol/mol] vs −0.72 ± 1.86% [8 ± 20 mmol/mol], P = 0.05).

CONCLUSIONS
Anti-GAD positivity identifies a group of patients with a different prognosis compared with patients without antibodies and those with type 1 diabetes. Patients with GAD+ responded differently to insulin compared with patients with GAD−.
Peningkatan Keterampilan Berbicara dengan Metode Bermain Peran Pada Siswa
Authors: Husada Anugerah , Asri Untari Mei Fita , Nashir Tsalatsa Ahmad 
Published: April 2019

Tujuan yang hendak dalam penelitian ini adalah 1) Meningkatkan keterampilan guru dalam pembelajaran bahasa Indonesia dengan menggunakan metode bermain peran, 2) Meningkatkan aktivitas belajar peserta didik dengan pembelajran bahasa indonesia dengan metode bermain peran, 3) Meningkatkan hasil belajar peserta didik dalam pembelajaran bahasa indonesia dengan menggunakan metode bermain peran. Jenis penelitian ini adalah penelitian tindakan. Subjek penelitian adalah guru dan seluruh peserta didik kelas IV SDN 02 Gidangelo tahun pelajaran 2018/2019. Sampel yang diambil adalah 29 peserta didik kelas IV dengan menggunakan data dalam penelitian ini diperoleh melalui tes, observasi, dan dokumentasi. Dari hasil penelitian diketahui bahwa terdapat peningkatan perolehan nilai keterampilan berbicara. Pada pratindakan nilai rata-rata 65,80 dan jumlah ketuntasan peserta didik sebesar 31%. Lalu pada siklus I diterapkan metode bermain peran memperoleh nilai rata-rata 75,86 dan jumlah ketuntasan peserta didik sebesar 62%. Artinya, penggunaan metode Bermain Peran dapat meningkatkan kemampuan berbicara peserta didik, akan tetapi hasil yang diperoleh belum melampaui target yang ditentukan peneliti sehingga dilanjutkan pada siklus II. Pada siklus II memperoleh nilai rata-rata 84,77 dan jumalh ketuntasan peserta didik sebesar 72%. Kesimpulannya bahwa metode Bermain Peran dapat meningkatkan kemampuan berbicara peserta didik.
Impact of body-mass factors on setup displacement during pelvic irradiation in patients with lower abdominal cancer
Authors: Wu Wei-Chieh , Chang Yi-Ru , Lai Yo-Liang , Shiau An-Cheng , Liang Ji-An , Chien Chun-Ru , Kuo Yu-Cheng , Chen Shang-Wen 
Published: April 2019

Abstract

Background
The aim of the study was investigate the impact of body-mass factors (BMF) on setup displacement during pelvic radiotherapy in patients with lower abdominal cancers.

Patients and methods
The clinical data of a training cohort composed of 60 patients with gynecological, rectal, or prostate cancer were analyzed. The daily alignment data from image-guided radiotherapy (IGRT) were retrieved. Setup errors for were assessed by systematic error (SE) and random error (RE) through the superior-inferior (SI), anterior-posterior (AP), and medial-lateral (ML) directions. Several BMFs and patient-related parameters were analyzed with binary logistic regression and receiver-operating characteristic curves. A scoring system was proposed to identify those with greater setup displacement during daily treatment. The results were validated by another cohort.

Results
A large hip lateral diameter correlated with a greater SI-SE and AP-SE, whereas a large umbilical AP diameter correlated with a greater ML-SE and ML-RE. A higher SI-RE was associated with a large hip circumference. The positive predictors for setup uncertainty were chosen to dichotomize patients into groups at high risk and low risk for setup displacement. Based on the scoring system, the adequate treatment margins for the SI direction in the high-and low-risk groups were 5.4 mm and 3.8 mm, whereas those for the ML direction were 8.2 mm and 4.2 mm, respectively. The validated cohort showed a similar trend.

Conclusions
Large BMFs including hip lateral diameter, hip circumference, and umbilical AP diameter are associated with greater setup uncertainty. Based on the scores, IGRT or required treatment margins can be adapted for patients with high risk features.
Development of microsatellite markers for the critically endangered conifer Glyptostrobus pensilis (Cupressaceae) using transcriptome data
Authors: Li Xin-Yu , Lin Xue-Ying , Ruhsam Markus , Chen Lu , Wu Xing-Tong , Wang Min-qiu , Thomas Philip I. , Wen Ya-Feng 
Published: April 2019

Abstract

Glyptostrobus pensilis (Cupressaceae) is a critically endangered conifer which occurs in China, Laos, and Vietnam where it is only known from a few populations. Here we aim to develop microsatellite markers which can be used to study the genetic variation within this species. Using transcriptome data we tested 170 SSR loci for polymorphism in 16 samples. Twenty-three loci were polymorphic and selected for the genetic analysis of 83 individuals from three Chinese populations. The number of alleles per locus and population ranged from one to eight, the observed and expected heterozygosity from H

o
= 0.00-1.00 and H

e
= 0.00-0.83, respectively. Fifteen loci deviated from Hardy-Weinberg equilibrium in at least one of the three populations. The majority of loci could also be successfully amplified in four related species, namely Cryptomeria fortunei, Taxodium distichum, Taxodium ascendens and Cunninghamia lanceolata. These developed microsatellites are suitable for population genetic studies of Glyptostrobus pensilis and related species.
Sengkulun as Betawi Traditional Cake Philosophy, Historical and Cultural Review
Authors: Tanius Billy , Sinaga Tiurma , Brahmantyo Himawan 
Published: April 2019

Betawi has a diversity of traditional food. One of the diversity of traditional foods of Betawi’s type of cake is Sengkulun cake. This rare cake is made from glutinous rice flour. Study was designed to recognize the Sengkulun cake from history, culture and philosophy as well as documenting the original way of making the cake which has begun to be forgotten. Descriptive qualitative approach was used to analyse data and information. Respondent were elders, i.e. Betawi cultural experts and Sengkulun cake makers. Experiment was conducted to obtain documentation in the form of photo and video which could make the cake more interesting to become Betawi ‘s snacks. Results show that the Sengkulun cake has existed for a long time but cannot be known with certainty the year of the creation of this cake. This cake began to be created because of the abundant availability of glutinous rice and also due to the influence of Chinese ethnic in the processing the snacks. The cake has a high position in ancient times because this cake can only be found in certain events such as Eid al-Fitr. From the Sengkulun's philosophy, it can be said that sticky texture of the Sengkulun cake has a symbol of respect each other.
Keywords: philosophy, Sengkulun, traditional cake
Working Rural Eco Tourism Planning in Yogyakarta Using MSP+DM Analysis
Authors: Priatmoko Setiawan 
Published: April 2019

Ecotourism planning requires a systematic simple tool. This is because generally the actors of ecotourism in the region of Yogyakarta is a rural community activist which need a simple tools. Ecotourism activities are often associated with village tourism activities managed by the local community as community based tourism (CBT). Using MSP + DM analysis helps facilitate the planning and development of ecotourism for all stakeholders.
Keywords: ecotourism, planning, rural, CBT, MSP+DM
Family Tourist - is Different Motive, Different Choice of Tourist Activity?
Authors: Ingkadijaya Rahmat 
Published: April 2019

Currently, many families travelling to various tourist destinations. This phenomenon is interesting to be investigated. Existing research results can be utilized by stakeholders to develop their own policies and strategies. However, at this time not much study exists in family travel. This study examines family’s travel motivations, family’s activities in destination, and the differences of family’s activity choice across categories of travel motivations. Survey method has been employed in this study. The sample was obtained from a residence in Bogor City, West Java and consisted of 300 families chosen by convenience sampling technique. Data were analyzed using descriptive analysis and hypothesis test using chi-square. The findings indicated that there were two dominant family’s travel motivations, personal escape and interpersonal seeking. The family chose natural, cultural, and special tourist activities. Family’s activity choice across categories of travel motivations was the same except rafting. It was most preferred by families who had personal escape motivation.
The Effects of "Search Engine Optimization" on Marketing of Diving Companies in Bali
Authors: Karisma Iola Astried , Darma Putra I Nyoman , Wiranatha Agung Suryawan 
Published: April 2019

The strategic location of the island of Bali which is surrounded by sea has a great potential for people in Bali to establish a diving company. Some diving companies in Bali have made various strategies to compete offering diving tour packages. Marketing through the internet is the best way that most diving companies in Bali have recently taken. However, to be able to compete with other similar companies on the internet, the website must be easily accessible to internet users, i.e. by appearing on the first page of the Google search engine. SEO or search engine optimization is an internet marketing strategy that serves to increase website visibility by targeting certain keywords. The use of SEO can have a positive impact on increasing online sales, increasing website visibility and brand awareness on the internet. This study aims to analyze the extent to which SEO techniques have a positive impact on the marketing of diving tourism in Bali through the internet, using quantitative descriptive methods. The research was conducted in three selected companies, namely Bali Diving, Atlantis Dune, and Scuba Adventure. The results of the study showed that diving companies in Bali have obtained all the positive impacts of SEO. These impacts were increasing website visibility, brand awareness, and sales.
Keywords: Diving in Bali, Internet Marketing, SEO, Bali Tourism.
Funcionalidad ejecutiva y aprendizaje en alumnado de primaria
Authors: Martínez Vicente Marta , Suárez Riveiro José Manuel , Valiente Barroso Carlos 
Published: April 2019

Introducción. Las funciones ejecutivas implican habilidades cognitivas y metacognitivas que configuran un sofisticado sistema de control y revisión de las conductas implicadas en la toma de decisiones, cruciales en la realización de las tareas y la conducta adaptativa. El control inhibitorio y atencional, la planificación, la autorregulación o la flexibilidad cognitiva son algunos de sus componentes directamente relacionados con el rendimiento académico. Este estudio examina la relación entre variables vinculadas al funcionamiento ejecutivo y al aprendizaje con el rendimiento en Matemáticas en alumnos de Educación Primaria.Método. Participaron en el estudio 519 alumnos de ambos géneros, con una edad media de 10.74 años (DT = .66), clasificados en tres grupos (bajo, medio y alto) según el rendimiento matemático.Resultados. Los resultados muestran relaciones significativas y negativas del rendimiento en matemáticas con el déficit de atención, hiperactividad e impulsividad; así como positivas con las estrategias de aprendizaje, la actitud hacia el estudio y el autoconcepto académico. Las diferencias entre los grupos de rendimiento matemático son significativas prácticamente en todas las variables estudiadas.Discusión y conclusiones. Es necesario plantear intervenciones en contextos escolares que tengan en cuenta tanto las funciones ejecutivas como el entrenamiento intencional en estrategias de aprendizaje, y así favorecer un mayor rendimiento académico.
Technological Platform for accessing school engagement and contextual factors, and providing online result reports
Authors: Saracostti Schwartzman Mahia , Lara Laura , Miranda Zapata Edgardo 
Published: April 2019

This technical report describes a web based plataform for accessing school engagement in its three dimensions (emotional, cognitive, and behavioural) and the contextual variables with influences in school engagement (family, teachers and peers). The platform delivers results online through individual reports on students sent to teachers and psychosocial teams as well as the pupil themselves and their parents or guardians, it also provides aggregate reports by grades and schools for teachers, psychosocial team and school managers to assist contextualised and informed decisions.This technological platform for accessing school engagement was developed in Chile. Ir is based on specially designed and psychometrally validated instruments for meassuring school engagement and contextual factors, and on a tool for predective modelling on student behavior and contextua factors. The platform is currently being adjusted and tested for use in other Ibero american countries (Peru, Uruguay, Colombia, and Spain).
Does Computer-based Elaborated Feedback Influence the Students’ Question-Answering Process?
Authors: Máñez Sáez Ignacio , Vidal-Abarca Gámez Eduardo , Martínez Giménez Tomás 
Published: April 2019

Introduction. Students usually answer comprehension questions from texts as part of their academic activities. Feedback has been found to be relatively effective to improve comprehension and learning from texts. However, there is little research on how computer-based feedback influences the question-answering process. This study examines the effects of elaborated feedback (EF) on the students’ question-answering performance and their accuracy to assess textual relevance. Further, the study explores whether EF influences the question, the text-search, and the feedback processing. Method. Seventy-five 7th and 8th grade students answered a set of questions having the text available. During the question-answering process, students were forced to highlight the text information they considered relevant to answer each question. While half of the students received EF on their question-answering performance and their accuracy to assess textual relevance, the other half had access to the same screens without formative feedback (i.e., control feedback group). Results. EF enhanced the students’ question-answering performance and reduced the amount of non-relevant text information students assessed as question-relevant. However, EF did not affect the question-relevant text information highlighted. Although EF did not influence the question and the text-search processing times in comparison to the control feedback group, students who received EF devoted more time and accessed additional information more often than the control group. Discussion and conclusion. Computer-based EF on the students’ question-answering performance and their accuracy to assess textual relevance can be efficient to improve the students’ question-answering process. This study sheds light on how to deliver EF in a digital environment. However, further research is necessary to explore the cognitive and metacognitive processes involved in feedback processing.