bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct additive manufacturing of large-sized crack-free alumina/aluminum titanate composite ceramics by directed laser deposition
Authors: Niu Fangyong , Wu Dongjiang , Huang Yunfei , Yan Shuai , Ma Guangyi , Li Chaojiang , Ding Jun 
Published: July 2019

Purpose
Direct additive manufacturing of ceramics (DAMC) is a highly promising ceramics preparation technology because of its simple process and rapid response capability, but the cracking issue prevents its industrial application. The purpose of this paper is to propose aluminum titanate (Al2TiO5) with low coefficient of thermal expansion (CTE) to suppress cracks during the DAMC.

Design/methodology/approach
Al2O3/Al2TiO5 (A/AT) composite ceramic samples with different compositions were in-situ synthesized from Al2O3/TiO2 (A/T) powder in a directed laser deposition (DLD) process. The relationship between the content of TiO2 and cracking characteristics of fabricated sample was discussed. Phase composition, microstructure and properties of the fabricated samples were also investigated.

Findings
The results of this paper show that the doping of TiO2 can obtain Al2TiO5 synthesized in situ by reaction with Al2O3 and effectively suppress cracks during DAMC. When the content of TiO2 reaches 30 wt.per cent, cracks hardly occur even under conditions of slow deposition. Crack-free structures such as vane, cone and pyramid were successfully prepared, with a maximum cross-sectional dimension of 30 mm and maximum length of 150 mm. A continuous matrix phase formed of the low CTE of Al2TiO5 is the major cause of crack suppression. The dispersed distribution of a-Al2O3 columnar dendrites has the effect of increasing the strength of the matrix. Under current process conditions, the prepared sample with 10 wt.per cent TiO2 has micro-hardness of 21.05 GPa and flexural strength of 170 MPa.

Originality/value
This paper provides a new method and inspiration for direct additive manufacturing of large-sized crack-free ceramics, which has the potential to promote practical application of the technology.
The Effect of Time and Temperature on the Persistence and Quality of Latent Fingerprints Recovered from 60‐Watt Incandescent Light Bulbs
Authors: Colella Olivia , Miller Marilyn , Boone Edward , Buffington‐Lester Sylvia , Curran Francis J. , Simmons Tal 
Published: July 2019

AbstractTo understand how time and temperature could affect latent fingerprints, wooden pallets were used to construct five units that each housed ten 60‐watt incandescent light bulbs. Fingerprints were deposited on the top, middle, and base of the globes. The bulbs were powered on (except the control bulb in each unit) for 18, 48, 72, 120, 168, 336, 504, and 672 h. Fingerprints recovered from the bulbs by tape lift after black powder processing were given a quality score. A thermal imaging camera determined temperatures on three areas of the bulbs. Fingerprints on the top of the globe (156.3°C) had the lowest quality score, and fingerprints on the middle of the globe (112.6°C) had the highest quality score. The mean quality scores of the three temperature classes were within one standard deviation of one another, meaning there is no way to estimate fingerprint age based on its quality after heat exposure.
Bankers closing idiosyncratic deals: Implications for organisational cynicism
Authors: Morf Manuela , Bakker Arnold B. , Feierabend Anja 
Published: July 2019

AbstractTo better meet flexibility demands and increase person–job fit, organisations might offer their employees the opportunity to negotiate task‐related arrangements, namely, idiosyncratic deals, referred to as “i‐deals.” However, not every employee who requests an i‐deal is successful in their negotiations. Thus, this study aims to further the knowledge of potential shortcomings of task‐related i‐deals and the role of supervisors in determining them. Drawing on social exchange theory, we hypothesise that low‐quality supervisor–employee relationships (i.e., leader–member exchange) are more likely to result in unsuccessful task‐related i‐deal negotiations, which consequently might provoke increased organisational cynicism. We analysed three waves of data from 202 Swiss bankers who had requested task‐related i‐deals within the investigated business cycle. The results supported our hypothesis. Our findings highlight the role of supervisors in reducing the potential costs of using task‐related i‐deals as employee‐initiated job design practices.
Chromosome‐level reference genome of X12, a highly virulent race of the soybean cyst nematode Heterodera glycines
Authors: Lian Yun , Wei He , Wang Jinshe , Lei Chenfang , Li Haichao , Li Jinying , Wu Yongkang , Wang Shufeng , Zhang Hui , Wang Tingfeng , Du Pei , Guo Jianqiu , Lu Weiguo 
Published: July 2019

AbstractSoybean cyst nematode (SCN, Heterodera glycines) is a major pest of soybean that is spreading across major soybean production regions worldwide. Increased SCN virulence has recently been observed in both the United States and China. However, no study has reported a genome assembly for H. glycines at the chromosome scale. Herein, the first chromosome‐level reference genome of X12, an unusual SCN race with high infection ability, is presented. Using whole‐genome shotgun (WGS) sequencing, Pacific Biosciences (PacBio) sequencing, Illumina paired‐end sequencing, 10X Genomics linked reads and high‐throughput chromatin conformation capture (Hi‐C) genome scaffolding techniques, a 141.01‐megabase (Mb) assembled genome was obtained with scaffold and contig N50 sizes of 16.27 Mb and 330.54 kilobases (kb), respectively. The assembly showed high integrity and quality, with over 90% of Illumina reads mapped to the genome. The assembly quality was evaluated using Core Eukaryotic Genes Mapping Approach and Benchmarking Universal Single‐Copy Orthologs. A total of 11,882 genes were predicted using de novo, homolog and RNAseq data generated from eggs, second‐stage juveniles (J2), third‐stage juveniles (J3) and fourth‐stage juveniles (J4) of X12, and 79.0% of homologous sequences were annotated in the genome. These high‐quality X12 genome data will provide valuable resources for research in a broad range of areas, including fundamental nematode biology, SCN–plant interactions and co‐evolution, and also contribute to the development of technology for overall SCN management.
Risk of opportunistic infections in patients with antineutrophil cytoplasmic antibody‐associated vasculitis, using a Japanese health insurance database
Authors: Sakai Ryoko , Tanaka Eiichi , Nishina Hirokazu , Suzuki Masayoshi , Yamanaka Hisashi , Harigai Masayoshi 
Published: July 2019

AbstractAimOpportunistic infections (OIs) adversely affect outcomes in patients with antineutrophil cytoplasmic antibody‐associated vasculitis (AAV). This study aimed to identify the incidence proportion of risk factors for OIs in patients with AAV who were on remission‐induction therapy, using a Japanese health insurance database.MethodThis retrospective longitudinal population‐based study was conducted using claims data provided by Medical Data Vision Co., Ltd. We defined individuals as AAV cases receiving remission‐induction therapy if they met all of the following criteria: (a) having OIs with at least 1 specified International Statistical Classification of Diseases and Related Health Problems, 10th Revision code (M300, M301, M313, or M318); (b) receiving at least 1 prescription of oral corticosteroids (CS) with prednisolone (PSL)‐equivalent dosage ≥30 mg/d, CS pulse therapy, immunosuppressive agents or rituximab during hospitalization between April 2008 and April 2017; and (c) at least 7 days of hospitalization while on the above‐mentioned therapies. We calculated incidence and proportion of OIs during the year following remission‐induction therapy and the adjusted odds ratio (OR) using a logistic regression model.ResultsWe included 2299 patients with AAV in this study. OIs occurred in 460 patients (20.0%), with the most frequently occurring OI being cytomegalovirus infection (n = 122, 6.5%). After adjusting for covariates, age by decade (OR 1.24, 95% CI: 1.12‐1.36), daily PSL dose per 10 mg (OR 1.16, 95% CI: 1.08‐1.25), and CS pulse therapy (OR 1.29, 95% CI: 1.04‐1.60) were found to be significantly associated with occurrence of OIs.ConclusionOlder age and corticosteroid use were found to be significant risk factors for OIs in patients with AAV on remission‐induction therapy, using a health insurance database.
Short progression‐free survival of ALK inhibitors sensitive to secondary mutations in ALK‐positive NSCLC patients
Authors: Haratake Naoki , Seto Takashi , Takamori Shinkichi , Toyozawa Ryo , Nosaki Kaname , Miura Naoko , Ohba Taro , Toyokawa Gouji , Taguchi Kenichi , Yamaguchi Masafumi , Shimokawa Mototsugu , Takenoyama Mitsuhiro 
Published: July 2019

BackgroundMost non‐small cell lung cancer (NSCLC) patients relapse on anaplastic lymphoma kinase‐tyrosine kinase inhibitor (ALK‐TKI) therapy because of acquired resistance. Rebiopsy is recommended to provide optimal therapy after relapse for some ALK‐TKI therapies; however, little clinical data exists on the clinical efficacy of ALK‐TKI tailored to secondary mutation.MethodsA retrospective study was conducted to analyze the patterns of ALK‐TKI treatment and clinical outcomes, including progression free survival (PFS), of ALK‐positive NSCLC patients who received rebiopsy. Based on the rebiopsy results, secondary mutations in the ALK gene that were shown to be associated with the efficacy of ALK‐TKI therapy in the preclinical or clinical setting were defined as “sensitive mutations (SM)”.ResultsAmong 71 patients who received ALK‐TKI for NSCLC at our institution, 20 patients received rebiopsy, and secondary SM were found in eight patients. The objective response rate (ORR) of the cases with SM who received ALK‐TKI therapy was 88.9%, while the ORR of the patients without SM who received ALK TKI or chemotherapy was 20.0%; however, the PFS of the patients with SM was relatively short (with SM vs. without SM: 5.6 months vs. 5.1 months).ConclusionsThe selection of ALK‐TKI based on the rebiopsy result was associated with a high ORR and relatively short PFS. The mechanism responsible for the short PFS of sensitive ALK‐TKI to secondary mutation should be clarified.
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala
Authors: Suárez Juan , Khom Sophia , Alén Francisco , Natividad Luis A. , Varodayan Florence P. , Patel Reesha R. , Kirson Dean , Arco Rocío , Ballesta Antonio , Bajo Michal , Rubio Leticia , Martin‐Fardon Rémi , Rodríguez de Fonseca Fernando , Roberto Marisa 
Published: July 2019

AbstractAdministration of selective serotonin reuptake inhibitors (SSRIs), typically used as antidepressants, induces long‐lasting behavioral changes associated with alcohol use disorder (AUD). However, the contribution of SSRI (fluoxetine)‐induced alterations in neurobiological processes underlying alcohol relapse such as endocannabinoid and glutamate signaling in the central amygdala (CeA) remains largely unknown. We utilized an integrative approach to study the effects of repeated fluoxetine administration during abstinence on ethanol drinking. Gene expression and biochemical and electrophysiological studies explored the hypothesis that dysregulation in glutamatergic and endocannabinoid mechanisms in the CeA underlie the susceptibility to alcohol relapse. Cessation of daily treatment with fluoxetine (10 mg/kg) during abstinence resulted in a marked increase in ethanol seeking during re‐exposure periods. The increase in ethanol self‐administration was associated with (a) reductions in levels of the endocannabinoids N‐arachidonoylethanolomine and 2‐arachidonoylglycerol in the CeA, (b) increased amygdalar gene expression of cannabinoid type‐1 receptor (CB1), N‐acyl phosphatidylethanolamine phospholipase D (Nape‐pld), fatty acid amid hydrolase (Faah), (c) decreased amygdalar gene expression of ionotropic AMPA (GluA2 and GluA4) and metabotropic (mGlu3) glutamate receptors, and (d) increased glutamatergic receptor function. Overall, our data suggest that the administration of the antidepressant fluoxetine during abstinence dysregulates endocannabinoid signaling and glutamatergic receptor function in the amygdala, facts that likely facilitate alcohol drinking behavior during relapse.
Cardiac autonomic dysfunctions are recovered with vitamin D replacement in apparently healthy individuals with vitamin D deficiency
Authors: Dogdus Mustafa , Burhan Sebnem , Bozgun Zeynal , Cinier Goksel , Koyuncu Ilhan , Yucel Karabay Can , Zoghi Mehdi 
Published: July 2019

AbstractBackgroundVitamin D (VitD) has important prohormone functions in a wide range of clinical processes. Although it is known that individuals with VitD deficiency have cardiac autonomic dysfunction, there are no convincing data regarding the effect of VitD replacement. We aimed to evaluate the impact of VitD replacement on cardiac autonomic dysfunction.MethodsFifty‐two apparently healthy subjects with VitD deficiency and 50 healthy control subjects were enrolled. Prior to VitD replacement, 24‐hr Holter recordings were obtained, and HRV parameters were recorded. VitD levels were measured 2 months later after replacement, and control 24‐hr Holter recordings were analyzed.ResultsThe mean age of the patients was 36.04 ± 7.6 years, and 53.9% were female. SDNN (68.58 ± 13.53 vs. 121.02 ± 27.45 ms, p = .001), SDANN (95.96 ± 22.26 vs. 166.48 ± 32.97 ms, p = .001), RMSSD (23 vs. 59 ms, p < .001), and PNN50 (6.5% vs. 36%, p < .001) were significantly lower in patients with VitD deficiency compared with the control group. HRV parameters were improved after VitD replacement [SDNN (68.58 ± 13.53 to 119.87 ± 28.28 ms, p < .001), SDANN (95.96 ± 22.26 to 164.44 ± 33.90 ms, p < .001), RMSSD (23 to 58 ms, p < .001), and PNN50 (6.5 to 33%, p < .001)].ConclusionThe present study suggested that VitD deficiency was significantly correlated with impaired cardiac autonomic functions assessed by parameters of HRV, and cardiac autonomic dysfunction improved after VitD replacement in otherwise apparently healthy individuals.
Evaluation of the novel total artificial heart Realheart in a pilot human fitting study
Authors: Pieper Ina Laura , Sonntag Simon Johannes , Meyns Bart , Hadi Hind , Najar Azad 
Published: July 2019

AbstractHeart failure affects >26 million patients worldwide. Current cardiac devices save lives, but patients suffer complications. Hence, improved devices are needed. Realheart TAH is a novel total artificial heart which has shown promising results in acute pig studies. However, the device design needed to be evaluated in humans. Virtual implantations demonstrated the device fits in two of three patients, but that there was some interference with the left lung. Herein, we used an innovative 3D‐printed model with swivelling device components to test the device in human cadavers. Our new method demonstrated how to optimize design to improve the surgical fit.
Associations of social relationships with curative and preventive dental care use among young and middle‐aged adults: Evidence from a population‐based study in Japan
Authors: Murakami Keiko , Aida Jun , Hashimoto Hideki 
Published: July 2019

AbstractObjectivesSocial relationships are important for diffusion of information and behaviours. Access to preventive dental care is more difficult than access to curative dental care under the Japanese universal healthcare system. Our objective was to examine whether social relationships were differentially associated with curative and preventive dental care use in Japan.MethodsA questionnaire survey was conducted between 2010 and 2011 among residents aged 25‐50 years in Japanese metropolitan areas. Valid responses were obtained from 1919 men and 2207 women. Social relationships included social networks (membership of organizations and number of close ties) and social support (informational support and instrumental support). Poisson regression analyses with robust variance estimators were conducted to examine associations between each social relationship variable and curative dental care use or preventive dental care use, adjusted for covariates.ResultsWhile 38.4% of men and 42.0% of women used curative dental care, 22.9% of men and 32.5% of women used preventive dental care in the past year. No measures of social relationships were associated with curative dental care use among men and women, except the number of close ties among men. By contrast, all measures of social relationships were associated with preventive dental care use among men; the multivariate‐adjusted prevalence ratios (95% confidence intervals) of the highest compared with the lowest level of social relationships were 1.58 (1.18‐2.13) for membership of organizations, 1.58 (1.24‐2.00) for the number of close ties, 1.41 (1.10‐1.82) for informational support and 1.30 (1.01‐1.68) for instrumental support. Among women, no measures of social relationships were associated with preventive dental care use.ConclusionsSocial relationships were associated with preventive dental care use among men but not among women, while these were not associated with curative dental care use.
Making fathers relevant: How practitioners include both parents in talk about parenting programmes
Authors: Symonds Jon 
Published: July 2019

AbstractParenting programmes are recommended as an effective means to support parents in promoting positive relationships with, and managing the behaviour of, their children. One barrier that impedes their successful implementation is that partners, especially fathers, are less frequently recruited by child welfare services. This article reports on a study that investigated how both parents were engaged with parenting services. Direct recordings were made of initial telephone conversations between six practitioners and 28 parents referred to those services and investigated for evidence of how the other parent was recruited. Conversation analysis was used to identify how participants introduced the possibility of both parents being included in the service, how these possibilities were negotiated, and what eventual agreements were made for both parents to be included in future arrangements. Implications for practice, training, and future research are considered.
Measuring cognitive insight in people with problematic substance use: An exploration of the factor validity of the Beck Cognitive Insight Scale
Authors: Raftery Dayle , Kelly Peter J. , Deane Frank P. , Mcketin Rebecca , Baker Amanda L. , Turner Alyna , Dean Olivia M. 
Published: July 2019

AbstractIntroduction and AimsInsight is a multi‐dimensional construct that predicts treatment outcomes of people with mental illness. Research into insight in substance dependent populations is limited and measures of cognitive insight have not been validated for this population.Design and MethodsA cross sectional survey was conducted with residents of nine residential substance dependence treatment facilities in Australia. Cognitive insight was assessed using the Beck Cognitive Insight Scale (BCIS). Psychological distress was assessed using the Kessler 6 (K6).ResultsParticipants (N = 312) were primarily male (68.6%), with an average age of 37.51 years (SD = 9.85). Methamphetamine (45.2%) and alcohol (35.9%) were the primary substances of use. A confirmatory factor analysis confirmed the two‐factor model of the BCIS (CMIN/DF = 2.91, CFI = 0.84). Removing two items from the Self‐Reflection subscale improved model fit (CMIN/DF = 2.71, CFI = 0.84, Χ 2[22, n = 312] = 76.43, P < 0.02). Internal consistency analyses indicated acceptable internal reliability (Self‐Reflection α = 0.73, Self‐Certainty α = 0.72, composite α = 0.75). Self‐Certainty scores were significantly higher for participants with a self‐reported psychotic disorder (M = 14.95 vs. M = 13.04, P = 0.007). Self‐Reflection scores were higher for people experiencing psychological distress (M = 17.57 vs. M = 15.95, P = 0.001).Discussion and ConclusionsWe found that a 12‐item version of the BCIS had good psychometric properties in this substance‐using population. Further research is needed to explore whether insight can predict treatment outcomes for substance use.
MEK inhibitor cobimetinib rescues a dRaf mutant lethal phenotype in Drosophila melanogaster
Authors: Pfeifle Isabelle , Bohnekamp Jens , Volkhardt Anna , Kirsten Holger , Rohwedder Astrid , Thum Andreas , Magin Thomas M. , Kunz Manfred 
Published: July 2019

AbstractSince Drosophila melanogaster has proven to be a useful model system to study phenotypes of oncogenic mutations and to identify new anti‐cancer drugs, we generated human BRAFV600E homologous dRaf mutant (dRafA572E) Drosophila melanogaster strains to use these for characterisation of mutant phenotypes and exploit these phenotypes for drug testing. For mutant gene expression, the GAL4/UAS expression system was used. dRafA572E was expressed tissue‐specific in the eye, epidermis, heart, wings, secretory glands and in the whole animal. Expression of dRaf A572E under the control of an eye‐specific driver led to semi‐lethality and a rough eye phenotype. The vast majority of other tissue‐specific and ubiquitous drivers led to a lethal phenotype only. The rough eye phenotype was used to test BRAF inhibitor vemurafenib and MEK1/2 inhibitor cobimetinib. There was no phenotype rescue by this treatment. However, a significant rescue of the lethal phenotype was observed under a gut‐specific driver. Here, MEK1/2 inhibitor cobimetinib rescued Drosophila larvae to reach pupal stage in 37% of cases as compared to 1% in control experiments. Taken together, the BRAFV600E homolog dRaf A572E exerts mostly lethal effects in Drosophila. Gut‐specific dRaf A572E expression might in future be developed further for drug testing.
Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma
Authors: Ishii Norihiro , Harimoto Norifumi , Araki Kenichiro , Muranushi Ryo , Hoshino Kouki , Hagiwara Kei , Gantumur Dolgormaa , Yamanaka Takahiro , Tsukagoshi Mariko , Igarashi Takamichi , Tanaka Hiroshi , Watanabe Akira , Kubo Norio , Shirabe Ken 
Published: July 2019

AimPostoperative ascites is one of the most common complications after hepatic resection and is related to liver fibrosis. Mac‐2 binding protein glycosylation isomer (M2BPGi) is a reliable and non‐invasive marker for assessing liver fibrosis. This study aimed to evaluate whether preoperative M2BPGi level can predict postoperative refractory ascites in patients with curative hepatic resection for hepatocellular carcinoma.MethodsThe present study retrospectively evaluated 59 patients between January 2016 and June 2018. We assessed the relationship between preoperative M2BPGi levels, expressed as the cut‐off index, and postoperative ascites.ResultsThe median M2BPGi level was 1.36 (range 0.34–11.56). Postoperative ascites occurred in seven patients (11.9%). Among them, refractory ascites, defined as diuretic‐resistant ascites, occurred in four patients (6.8%). Uni‐ and multivariate analysis showed that preoperative M2BPGi level was the only independent risk factor of postoperative ascites (odds ratio 3.28, P = 0.033). The cut‐off values of M2BPGi for postoperative ascites and refractory ascites were 2.41 and 3.10, respectively. Remarkably, there were no patients with postoperative ascites and refractory ascites when the preoperative M2BPGi levels were less than each cut‐off value.ConclusionOur results suggest that M2BPGi level is a reliable and non‐invasive surrogate marker for predicting postoperative ascites before curative resection for hepatocellular carcinoma.
Measurement Error Skin Colour and the Role of the Interviewer
Authors: Cernat Alexandru , Sakshaug Joseph W. , Castillo Javier 
Published: July 2019

AbstractInterviewer effects are a well-known problem in survey research. Less well known is whether the skin colour of interviewers can affect their assessments of the skin colour of respondents. Alexandru Cernat, Joseph W. Sakshaug and Javier Castillo investigate