bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Drug Side Effects with Compact Integration of Heterogeneous Networks
Authors: Zhao Xian , Chen Lei , Guo Zi-Han , Liu Tao 
Published: February 2019

Background:The side effects of drugs are not only harmful to humans but also the major reasons for withdrawing approved drugs, bringing greater risks for pharmaceutical companies. However, detecting the side effects for a given drug via traditional experiments is time- consuming and expensive. In recent years, several computational methods have been proposed to predict the side effects of drugs. However, most of the methods cannot effectively integrate the heterogeneous properties of drugs.Methods:In this study, we adopted a network embedding method, Mashup, to extract essential and informative drug features from several drug heterogeneous networks, representing different properties of drugs. For side effects, a network was also built, from where side effect features were extracted. These features can capture essential information about drugs and side effects in a network level. Drug and side effect features were combined together to represent each pair of drug and side effect, which was deemed as a sample in this study. Furthermore, they were fed into a random forest (RF) algorithm to construct the prediction model, called the RF network model.Results:The RF network model was evaluated by several tests. The average of Matthews correlation coefficients on the balanced and unbalanced datasets was 0.640 and 0.641, respectively.Conclusion:The RF network model was superior to the models incorporating other machine learning algorithms and one previous model. Finally, we also investigated the influence of two feature dimension parameters on the RF network model and found that our model was not very sensitive to these parameters.
An Assessment of Digital Media-related Admissions in Psychiatrically Hospitalized Adolescents
Authors: Gansner Meredith , Belfort Erin , Leahy Caroline , Mirda Danielle , Carson Nicholas 
Published: February 2019

Background:
Prevalent adolescent digital media use has brought clinical attention
to its potential associated risks. While excessive digital media use has been connected to adolescent
difficulties with mood and impulsivity, no study has examined digital media’s role in
precipitating adolescent psychiatric admissions.

Objective:
Our study aims were to identify and characterize digital media-related admissions
in a sample of psychiatrically hospitalized adolescents, and to recognize unique patterns of
digital media use within this sample. We hypothesized that adolescents with digital mediarelated
admissions would endorse higher amounts of digital media use and problematic online
behaviors.

Methods:
We administered a cross-sectional survey of psychiatrically hospitalized adolescents
between 2012 and 2016. Admissions were considered related to digital media use either
by adolescent report or documentation in the medical record. Unadjusted comparisons
were used to examine relationships between digital media-related psychiatric admissions, online
behaviors and suicide-related risk factors.

Results:
68 of 218 participants (31.2%) had digital media-related admissions. The most frequent
cause of digital media-related admission was cyberbullying (31.9%). Teens with digital-
media related admissions were significantly more likely to sext, use social media, and be
cyberbullied; these adolescents were also at increased risk of suicide planning and hopelessness.

Conclusion:
Efforts should be made by mental health clinicians to identify and address online
relational conflict, as well as to screen for cyberbullying and sexting. Clinicians should
consider that adolescents with digital media-related presentations may be at elevated risk of
self-harm, with higher rates of suicide planning and hopelessness compared to hospitalized
peers with admissions unrelated to digital media.
Kidneys functional state in patients suffered purulent pyelonephritis
Authors: Sinyakova L. A. , Bernikov E. V. , Loran O. B. 
Published: February 2019

Introduction. Purulent pyelonephritis is a complicated urinary tract infection with one of the most severe currents. It represents a serious clinical problem associated with the complexity of the choice of diagnosis and the optimal active treatment strategy, as well as the need for subsequent rehabilitation of this category of patients.Purpose of the study. Studying of the immediate and remote results of the kidneys` functional state in patients who have undergone purulent pyelonephritis using a differentiated approach to treatment tactics.Materials and methods. The study included 84 patients who underwent purulent pyelonephritis at the age of 15 to 70 years old and were treated at the Botkin City Clinical Hospital from 1999 to 2007. The patients were divided into three groups depending on the method of treatment: group 1 - open surgery of 18 patients (21.4%); group 2 - percutaneous drainage methods - 38 (45.3%); group 3 - conservative therapy - 28 (33.3%) patients. Examination of patients included dynamic nephroscintigraphy and complex ultrasound. It was performed in time after treatment after 12, 36 and 60, 84 months.Results. During the 7-year observation of patients, it was found that a more pronounced renal dysfunction and perfusion occurred during all periods of observation after undergoing open surgery according to Doppler sonography. Restoration of renal function occurred in shorter observation periods after the use of percutaneous kidney drainage and conservative treatment.Conclusion. Based on the data obtained, it can be concluded that a differentiated approach to the choice of tactics for the treatment of patients with purulent pyelonephritis is reasonable. Accordingly, it should be introduced into clinical practice of urological departments that provide emergency care to urological patients.
Support Teacher as Key Factor of Integration Children with Special Education Needs in Mainstream School
Authors: Voinea Mihaela , Topală Ioana Roxana 
Published: February 2019

Abstract
The issue of integrating children with special educational needs in mainstream school depends on several factors. The most important is the support teacher, who is the link between school, family and community, between children and teachers and other specialists. (Avramidis & all 2000, Ainscow 2016, etc.). Teachers need to change their own mind set and system of values according to the new social responsibilities in order to become promoters of human diversity, acceptance and tolerance. Therefore, teacher training must respond diligently to the new teacher’s roles and responsibilities. The main purpose of this research was to identify the training needs for support teachers based on the analysis of their own socio-educational experience (their own role and their particular training needs as support teachers), as well as (mainstream school) teachers’, pupils’ and parents’ perceptions regarding integration. This study was conducted in a mixt methods structure, which employed both quantitative and qualitative methods for data collection. A questionnaire-based survey was conducted, with mainstream teachers, on one hand, and parents, on the other hand. We addressed the issues of attitudes towards the integration of children with SEN (special education needs) and the collaboration with the support teacher. Also, focus-group interviews were conducted with support teachers. A number of 112 participants were included in the study (57 teachers from mainstream schools, 20 support teachers, and 35 parents ) Conclusion: Teachers’ and parents’ cognitive schemas regarding what a support teacher can and should do in order to facilitate the integration of children with SEN are different from his/her actual educational role and responsibilities. This gap between the social representations and the actual job description can be bridged by building a more complex and accurate understanding of how every actor involved in the integration process must become aware of one’s personal beliefs and expectations, assume and thoroughly play his/her part in a collaborative manner. Teacher training through transformative learning based on sharing experiences and group projects is a learning experience suitable for developing competences for teachers for special education.
Ear Training Made Easy: Using IOS Based Applications to Assist Ear Training in Children
Authors: Serdaroglu Emine 
Published: February 2019

Abstract
It is an inevitable reality that in all developed countries and in most developing countries, smart phones and tablets are an indispensable part of most children’s lives. There are many discussions and heated arguments on the negative and positive effects of digital technology on the development of children. In this paper, accepting the fact that this technology is a part of most children’s daily lives, it will be questioned whether this technology may be used to reinforce certain components of music education in general classroom and especially in private music studios. In conservatories and music schools, a considerable amount of time is dedicated to aural training of younger students. However, during music lessons in the classroom and during the instrumental lessons in private studios, lesson time is mostly dedicated to other components such as improvement of technique, musicality and sight reading. Thus, a crucial part of music education “ear training” is neglected to some extent. In this paper, several IOS based ear training applications will be evaluated considering the target group, children between ages 6-11. The possible effects and incorporation of these applications into the classroom and private studios will be discussed. Each application will be evaluated on several components; the ear training modules, user-friendliness, possibility of the evaluation of students’ progress by the teacher and probable reaction of the children to these applications.
Multiple Primary Synchronous Renal Cancer and Thyroid Gland Cancer at Patient with Doubling Inferior Vena Cava and Renal Veins on Both Sides (Clinical Case)
Authors: Stepanova Yu. A. , Teplov A. A. , Morozova M. V. , Gritskevich A. A. , Pyanikin S. S. , Chekhoeva O. A. , Karelskaya N. A. , Glotov A. V. 
Published: February 2019

Renal cell carcinoma – the third on occurrence frequency tumor of urinogenital system and the most widespread renal tumor which makes about 2–3% of malignancies at adults. Doubling of inferior vena cava (IVC) is anomaly in case of which two inphrarenal segments of IVC are defined. Left IVC after lockin in it the left renal vein crosses an aorta in front, connects to the right renal vein and the right IVC. Combination of renal cell carcinoma and doubling IVC is rather seldom. The presented clinical case of a combination of renal cell carcinoma and doubling of IVC has the feature existence at the patient of metachronous multiple primary neoplasms that does necessary more careful inspection of the patient. Also a doubling of renal veins on both sides and a doubling of the left renal artery have been revealed. Possibilities of presurgical non-invasive diagnostics (ultrasonography and computer tomography) of retroperitoneal space vessels anomaly at the patient with transmural localization of kidney tumor allowing to plan and execute difficult surgery – an ex vivo resection of a left kidney in the conditions of pharmacological cold ischemia was shown. Performance of an ex vivo nephrectomy in the conditions of pharmacological cold ischemia allows to dilate indications to organ-preserving treatment of patients with the localized kidney cancer. However long cold ischemia and the subsequent vascular reconstruction demand dynamic observation over kidney’s functional conditions.
Radiological Diagnosis of Spontaneous Intercostal Pulmonary Hernia (Clinical Observation)
Authors: Sheikh Zh. V. , Arablinsky A. V. , Borzunova N. N. , Ulyanov S. A. 
Published: February 2019

Pulmonary or intercostal hernia appears as a bulge lung tissue result in the subcutaneous fat through a natural orifice or pathologically caused defects of the chest wall. Difficulties of diagnosis of the true pulmonary hernia owing to extremely infrequent occurrence of this pathology are, as a rule, bound to poor knowledge of doctors and quite often lead to inaccurate medical tactics. In the diagnosis of lung hernia along with clinical and laboratory data are used such research methods as x-ray, ultrasound, CT, among which, CT is a highly informative investigation method that allows to evaluate the status of lung tissue in the hernia sac and in other parts of the lungs, just to visualize the structures of the mediastinum, as well as the condition of the pleural cavity and chest wall, determining its proper treatment.
The Use of Magnetic Resonance Imaging in Patients with Chronic Paraproctitis (Preliminary Results)
Authors: Shelygin Y. A. , Eligulashvili R. R. , Zarodnyuk I. V. , Kostarev I. V. , Chernozhukova M. O. 
Published: February 2019

Aim.Investigation of possibilities of magnetic resonance imaging as a whole, as well as different modes of MR scanning (without intravenous contrast, with intravenous contrast, with the use of diffusion-weighted imaging) in the diagnosis of cryptogenic fistulas of the rectum.Materials and methods. In the study were included 50 patients with cryptogenic fistulas of the rectum (21 women and 29 men). All patients underwent magnetic resonance imaging of the pelvic organs.Results.The sensitivity of MRI in the diagnosis of the primary fistulas was 100%. With regard to secondary fistulas MRI sensitivity was 91.7%, specificity was 94.3%. The sensitivity of MRI in the diagnosis of chronic abscesses paraproctitis was 82.6%, specificity was 95.2%. The sensitivity of the method in the visualization of internal opening was 95.5%, specificity was 80.0%. The sensitivity of the method in the diagnosis of external openings was 91.7% and specificity was 100%. In the analysis of separates MR scanning mode we didn’t find statistically significant differences between them (p < 0.05). Conclusions.Magnetic resonance imaging has a high diagnostic efficacy in the diagnosis of cryptogenic perianal fistulas. We didn’t find statistically significant differences between MR scanning modes.
The Diagnosis of Breast Cancer after Augmentation Mammoplasty (Case Report)
Authors: Vasilev A. Yu. , Pavlova T. V. , Kasatkina L. I. , Manuylova O. O. , Rotin D. L. 
Published: February 2019

The number of women resorting to endoprosthesis replacement of breast is growing from year to year. To date, the most popular and safe method of correcting the shape and size of the breast is augmentation mammoplasty with silicone gel prostheses. Unfortunately, the diagnosis of breast cancer in patients who have had recourse to the augmentation mammoplasty at preclinical stages, is difficult. Most often this is due to the fact that the patient does not undergo preventive examinations. This research exemplifies a comprehensive procedure facilitating diagnostication of a breast cancer in a patient previously subjected to augmentation mammoplasty. A physical examination, a digital and an ultrasound mammography reveals a BI-RADS 5 nodal formation in the patient’s right breast. An ultrasound-guided biopsy of the newly formed tissue over the breast implant is morphologically cross-checked. The diagnosis of breast cancer is thus confirmed histologically.
A Score of Run-Off (Outflow) Resistance in Lesions Femoropopliteal Arteries Using MSCT Angiography
Authors: Maslov A. L. , Zotikov A. E. 
Published: February 2019

Despite the ongoing treatment, in 10–20% of patients with obliterating diseases of the arteries of the lower limbs, the progression of the disease leads to amputation, with mortality rates being up to 50%.The aim: to determine the effectiveness of MSCT angiography in patients with type-D femoral-popliteal arteries according to TASC II with critical ischemia of the lower extremities and poor condition of outflow tracts for performing arterialization of venous blood flow and / or superimposition of arteriovenous fistula.Material and methods. 145 MSCT angiographic studies were performed for patients with arterial diseases of the lower extremities performed in “RAMSAY Diagnostics Rus”Moscow. For the analysis, 53 (37% of the total) of the patient with lesions of the femoropopliteal segment of Type D according to TASC II were selected. The analysis of the state of the arterial outflow pathways was carried out according to the modified Rutherford classification, where each artery of the shin was maximally assigned 3 points depending on the degree of stenosis, the blood flow resistance was estimated as 0 points – the absence of stenosis or stenosis less than 20%, 1 point stenosis 20–49% 2 points stenosis 50–99%, 3 points – occlusion.Results. The degree of resistance of arteries of outflow tracts of 39 limbs (16 right and 23 left) was calculated in 53 patients: 10 points in 23.7% of cases; 9 points in 5.1%; 8 points – 2.5%; 7 points 18%, 6 points in 5%; 5 points 2.5%; 4 points 15.4%; 3 points 7.7%; 2 points 0; 1 point 20.5%. In patients with poor arterial outflow, with a score greater than 7, there is a high risk of early thrombosis of the prosthesis, so such patients undergo an operation with the formation of an unloading arteriovenous fistula.Conclusion. MSCT angiography of the arteries of the lower extremities is an effective method for determining the severity of arterial damage with an accurate definition of the level, extent, prevalence with the possibility of using different classifications, including TASC II and theRutherford classification. It can be used as a screening, expert method in patients with arterial diseases of the lower extremities, may be an alternative to direct angiography, used to assess patients in the postoperative period.Key words: peripheral arterial disease, outflow score, ball classification of outflow tracts, runoff score, computed tomography, angiography.
Effectiveness of Multimodality Imaging in Differential Diagnostics of Nonpalpable Breast Architectural Distortion
Authors: Jakobs O. E. , Rozhkova N. I. , Kaprin A. D. 
Published: February 2019

Objective:the aim of the study was to estimate the informative value of multimodality imaging in differential diagnostics of nonpalpable breast architectural distortion of different origin.Matherials and methods.We analyzed the results of multimodality examination of 307 women with nonpalpable breast architectural distortion of different origin. They underwent mammography, handheld sonography (B-mode), compressive elastosonography, Doppler angiography, automated breast volume US-scanning, US-guided core needle biopsy (n = 115; 38%) and stereotactic core needle biopsy (n = 192; 62%), pathomorphologic analysis. Results.Breast cancer were diagnosed in 221 (72%) women, benign lesions – in 86 (28%) women. Surgical treatment was performed In 254 (83%) cases and 31 (10%) breast lesions were removed with vacuum-assisted aspiration biopsy.Conclusion.Multimodality imaging with the invasive procedures gave 92.5% sensitivity, 100% specificity, 100% showed positive prognosis, 72.5% negative prognosis, 93.1% accuracy index.
The Role of Cone-Beam Computed Tomography in Diagnostics of Cystic Masses of the Jaw
Authors: Batova M. A. 
Published: February 2019

Research objective. The study aimed to evaluate cone-beam computed tomography (CBCT) capabilities in diagnostics of cystic masses of the jaw.Methods. Over a period of 2015–2016 32 patients age 6 to 67 underwent both panoramic tomography and CBCT (using panoramic tomographic scanner STRATO 2000 and cone-beam computed tomographic scanner i-Cat respectively). 47% (n = 15) of the participants were women, 53% (n = 17) – men. Radiation exposure for a single procedure amounts to 0,05 mSv for panoramic tomography, 0,07 mSv for CBCT (FOV =13 cm), 0,06 mSv for CBCT (FOV =8 cm).Results. Comparative analysis of obtained results demonstrates that CBCT showed 54% (n = 27) more cystic masses of the jaws than panoramic radiography could. CBCT additionally showed the following pathologies: granulomas smaller than4 mm diameter – 85% (n = 23), 83% (n = 23) of said granulomas were found on maxilla, radicular cysts of maxilla – 11% (n = 3), incisive canal cyst – 4% (n = 1). Additionally panoramic tomography analysis misdiagnosed 5 granulomas (80% (n = 4) on mandibular premolar and molar areas) that were not found during CBCT analysis.Conclusion. The low effective dose and high informativity of CBCT enables the method to be used instead of intraoral radiography, panoramic tomography and MSCT as a screening procedure in diagnostics of dento-facial system pathologies, including cystic masses of the jaw.
MDCT in Imaging of Hyperperfusion Syndrome after Carotid Surgery
Authors: Vishnyakova M. V. 
Published: February 2019

Aim: to assess MDCT abilities in imaging hyperperfusion syndrome (HPS) after carotid surgery.Materials and methods. Cases of hyperperfusion syndrome after carotid revascularization were analyzed at 595 patients underwent surgery during 2012–2016. Preoperatively complex visualization: ultrasound imaging of brachiocephalic arteries and cerebral vessels, computer tomography of the brain, computed angiography (CTA) brachiocephalic arteries and cerebral vessels, perfusion computer tomography (PCT). Computer tomography was held with Philips iCT 256 slices. During CTA 50 ml on nonionic contrast media was injected (4–4.5 ml/sec flow) with further arterial and venous phases. PCT covered 6 sm (basal ganglia and cerebral hemispheres), 35 cycles with 2 sec interval. If HPS was considered all patients underwent CT: non-contrast brain imaging, CTA and PCT (in stable patient condition). Further dynamic imaging was made at MRI 3 Tl with standard sequences (T1, T2, FLAIR, DWI).Results. HPS was detected in 7 cases, all patients had characteristic clinical presentation. According to imaging data all patients could be divided in three groups. Diffuse hemispheric edema on the operation side – 3 cases, at follow up imaging – regression of changes. Hemorrhagic component – 2 patients, one – with small hemorrhagic focus, another – with massive intracerebral hematoma. In 2 cases there were no new cerebral lesions detected. At CTA and PCT – increase of cerebral flow after operation. Mortality in patients with HPS was 28% (2 patients). In other cases there was regress of clinical symptoms.Conclusion. In all cases in our study the one was able to either to diagnose either to suggest HPS on the CT data. Detailed analyses of acquired data and comparison with clinical status were necessary, sometimes – follow up studies were essential.