bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of 1,639 hepatectomies for non‐colorectal non‐neuroendocrine liver metastases: a multicenter analysis
Authors: Sano Keiji , Yamamoto Masakazu , Mimura Tetsushige , Endo Itaru , Nakamori Shoji , Konishi Masaru , Miyazaki Masaru , Wakai Toshifumi , Nagino Masato , Kubota Keiichi , Unno Michiaki , Sata Naohiro , Yamamoto Junji , Yamaue Hiroki , Takada Tadahiro ,   on behalf of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Published: October 2018

AbstractBackgroundWhether non‐colorectal non‐neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear.MethodsData regarding 1,639 hepatectomies performed between 2001 and 2010 for 1,539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post‐hepatectomy outcomes were analyzed.ResultsThe five most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%]). R0/1 hepatectomy was achieved in 90% of patients, with 1.5% in‐hospital mortality rate. Overall and disease‐free survival rates of 1,465 patients included in survival analysis were 41% and 21%, respectively, at 5 years, and 28% and 15%, respectively, at 10 years. Five‐year survival associated with the five frequent primary tumors were 32%, 72%, 17%, 52%, and 31%, respectively, and factors predictive of a poor outcome differed by the primary tumor type.ConclusionsOur data indicated that hepatectomy is safe for NCNNLM and that patient prognoses vary depending on the type of primary tumors. Indications for hepatectomy should be determined with reference to survival rates and risk factors specific to each of the various types of primary tumor.
Design, Synthesis, and In Vitro Anti‐Tumor Activities of 1,2,3‐triazole‐tetraethylene Glycol Tethered Heteronuclear Bis‐Schiff Base Derivatives of Isatin
Authors: Wang Ruo , Yin Xueyang , Zhang Yaohuan , Zhang Tesen , Shi Weixiong 
Published: October 2018

We report herein the design, synthesis, and in vitro anti‐tumor activities of a series of 1,2,3‐triazole‐tetraethylene glycol tethered heteronuclear bis‐Schiff base derivatives of isatin. Our results indicated that all the synthesized bis‐Schiff bases except 9e showed considerable in vitro anticancer activities against HepG2, Hela, HCT‐116, A549, and MCF‐7 human cancer cell lines with IC50 in a range of 9.79–48.75 μM and were more potent than etoposide against Hela, HCT‐116, and A549 cell lines. In particular, the most potent bis‐Schiff base 9g (IC50: 9.79–29.64 μg/mL) was highly active against the five cancer cell lines tested, could act as a lead for further optimization.
Fractional order FIR differentiator design using particle swarm optimization algorithm
Authors: Kumar Manjeet 
Published: October 2018

AbstractIn this paper, a population‐based evolutionary optimization technique called particle swarm optimization (PSO) is applied for the optimization of system coefficients of the finite impulse response‐fractional order differentiator (FIR‐FOD) design problem. The conventional FIR‐FOD design methods are not efficient for nonlinear, nonuniform, and multimodal design problem due to getting trapped in local optimal solution. To overcome this problem, global optimization techniques are required. The superior FIR‐FOD design capability of the proposed method is evident from the results obtained through an exhaustive simulation study. Simulation results demonstrate that the proposed FOD design technique using PSO outperforms the genetic algorithm in terms of design accuracy (magnitude error and phase error), speed of convergence, and optimal solution. The simulation results have also been compared with those obtained by the conventional FOD design methods such as DFT interpolation, radial basis function (RBF) interpolation, DCT interpolation, and DST interpolation methods.
Sex, ADHD symptoms, and CHRNA5 genotype influence reaction time but not response inhibition
Authors: Schote Andrea B. , A. L. Sayk Clara , Pabst Kathrin , Meier Jacqueline K. , Frings Christian , Meyer Jobst 
Published: October 2018

AbstractPeople showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We examined the effects of two functional polymorphisms rs3841324 (S/L) and rs16969968 (G/A) of the cholinergic gene CHRNA5, ADHD symptoms and sex on response inhibition/reaction time in the Stop Signal Task. In the analyses, 183 participants (52.4% females) were included. In participants carrying the diplotype (SS_GG), men with ADHD symptoms responded faster, while men without ADHD symptoms were slower than women (F = 5.313; p = 0.023; ηp² = 0.034). Although explorative, this threefold interaction on reaction time but not response inhibition extend previous findings, suggesting a moderating effect of ADHD symptoms in men carrying the CHRNA5 diplotype SS_GG and might inspire research on genotype‐ and gender‐specific ADHD medication.
Overtime work as the antecedent of employee satisfaction, firm productivity, and innovation
Authors: Ko Young Jin , Choi Jin Nam 
Published: October 2018

SummaryOvertime work has been blamed for the deterioration of employee satisfaction and productivity. However, the organization‐level implications of overtime work as a normative expectation remain unclear. In this study, such effects were analyzed through human capital theory and a causal attribution approach. Various organizational outcomes and boundary conditions were explored in explaining these implications. The analysis of time lagged data from 273 firms affirmed that a firm's overtime level was related negatively to employee satisfaction. However, it was positively related to the firm's productivity and curvilinearly (inverted U‐shaped) related to innovation. The effects of the firm's overtime level on firm productivity and innovation were also moderated by organizational trust. This study highlights the costs and benefits of overtime work as tools for utilizing human capital and reveals the critical contingency of organizational trust that enables firms to attenuate the costs of the overtime level and accentuate its potential benefits.
The role of other orientation in reactions to social and economic leader–member exchange relationships
Authors: Buch Robert , Kuvaas Bård , Dysvik Anders 
Published: October 2018

SummaryIn this study, we investigate, through two study samples, whether relationships between social leader–member exchange (SLMX) and economic leader–member exchange (ELMX) relationships and outcomes differ depending on the followers' level of other orientation or the extent to which they are concerned for the welfare of others. We propose that followers with higher other orientation would respond less negatively to higher levels of ELMX and more positively to higher levels of SLMX because they are less likely to engage in behaviors based on rational and self‐interested calculations. In Study 1 (N = 200), we found that higher other orientation mitigated ELMX's negative relations with affective commitment and turnover intention. In Study 2 (N = 4,518), we both replicated the findings from Study 1 and also found that higher other orientation mitigated ELMX's negative relations with work effort. We also uncovered a weaker positive relationship between SLMX and organizational citizenship behavior for followers with higher other orientation.
Effects of Sodium Benzoate and Sodium Chloride on the Aggregation Behaviors of PEO‐PPO‐ph‐PPO‐PEO and PPO‐PEO‐ph‐PEO‐PPO at the Air/Water Interface
Authors: Gong Houjian , Xu Long , Xu Guiying , Zhu Teng , Dong Mingzhe 
Published: October 2018

AbstractThe effect of sodium benzoate and sodium chloride on the aggregation behavior of PEO‐PPO‐ph‐PPO‐PEO (BPE) and PPO‐PEO‐ph‐PEO‐PPO (BEP) polyethers at the air/water interface was investigated by measuring the equilibrium surface tension, surface dilational viscoelasticity, and surface tension relaxation. The measurements of surface tension showed that sodium benzoate has a better effect on decreasing the surface tension of BPE and BEP solutions than NaCl, especially when the polyether concentrations are low. According to dilational viscoelasticity measurements, the concentration of BPE required for the maximum dilational modulus is lower than that of BEP, indicating that BPE more easily forms a compact adsorbed layer. The dilational modulus values of BPE solutions in the presence of sodium benzoate and NaCl first increase and then decrease after passing through a maximum, and then they increase again with increasing electrolyte concentration. On the other hand, the dilational modulus values of BEP solutions in the presence of sodium benzoate and NaCl first increase to a maximum and then decrease with increasing electrolyte concentration. The surface tension relaxation results are consistent with those of dilational viscoelasticity. The different effects of sodium benzoate and NaCl on the polyether aggregation behaviors are caused by the strong hydrophobic and π‐π interactions between polyethers and sodium benzoate. This work has a great importance for the application and development of polyethers.
The competitiveness of solvent adsorption on polar‐embedded stationary phases
Authors: Krzemińska Katarzyna , Dembek Mikołaj , Bocian Szymon 
Published: October 2018

AbstractSolvation processes on polar embedded stationary phases were investigated by determination of excess isotherms in binary acetonitrile/water mobile phase. The obtained results indicate the competitiveness of acetonitrile and water adsorption on heterogeneous surfaces of chemically bonded stationary phases. The calculation of excess isotherm as a volume of excessively accumulated solvent confirms the competitiveness of solvents' adsorption in qualitative and quantitative meaning. Corresponding excess isotherms of water and acetonitrile are symmetrical with respect to the x‐axis. It confirms that the displaced volume of acetonitrile is replaced by an equal volume of water and vice versa. Additionally, fitting the two‐site adsorption model to experimental data provides quantitative values with low experimental errors. The obtained results confirm the advantage of volumetric assumption of excess adsorption over direct adsorption layers of solvents, which is commonly postulated.
The toxic edge—A novel treatment for refractory erythema and flushing of rosacea
Authors: Friedman Or , Koren Amir , Niv Roni , Mehrabi Joseph N. , Artzi Ofir 
Published: October 2018

PurposeRosacea is a common, chronic facial skin disease that affects the quality of life. Treatment of facial erythema with intradermal botulinum toxin injection has previously been reported. The primary objective of the study was the safety and efficacy of thermal decomposition of the stratum corneum using a novel non‐laser thermomechanical system (Tixel, Novoxel, Israel) to increase skin permeability for Botulinum toxin in the treatment of facial flushing of rosacea.MethodsA retrospective review of16 patients aged 23–45 years with Fitzpatrick Skin Types II to IV and facial erythematotelangiectatic rosacea treated by Tixel followed by topical application of 100 U of abobotulinumtoxin. A standardized high‐definition digital camera photographed the patients at baseline and 1, 3, and 6 months after the last treatment. Objective and subjective assessments of the patients were done via Mexameter, the Clinicians Erythema Assessment (CEA), and Patients self‐assessment (PSA) scores and the dermatology life quality index (DLQI) validated instrument.ResultsThe average Maxameter, CEA, and PSA scores at 1, 3, and 6 months were significantly improved compared with baseline (all had a P‐value <0.001). DLQI scores significantly improved with an average score of 18.6 at baseline at 6 months after treatment (P < 0.001). Self‐rated patient satisfaction was high. There were no motor function side‐effects or drooping.ConclusionThermal breakage of the stratum corneum using the device to increase skin permeability for botulinum toxin type A in the treatment of facial flushing of rosacea seems both effective and safe. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
Change in the intestinal bacterial community structure associated with environmental microorganisms during the growth of Eriocheir sinensis
Authors: Wang Chenhe , Zhou Yanfeng , Lv Dawei , Ge You , Li Huan , You Yang 
Published: October 2018

AbstractAs an important organ to maintain the host's homeostasis, intestinal microbes play an important role in development of the organism. In contrast to those of terrestrial animals, the intestinal microbes of aquatic organisms are affected by environmental microorganisms (including water microorganisms and sediment microorganisms). In the present study, the compositional differences of intestinal microbes in three representative developmental stages of the Chinese mitten crab (Eriocheir sinensis) were studied. Meanwhile, network association analysis, and visualization of the water microorganisms of the crabs’ habitat, the environment microorganisms in the pond, and the intestinal microbes, was carried out. The results showed that the gut microbiota diversity index decreased continuously with age, and the four bacteria of Aeromonas (Proteobacteria), Defluviitaleaceae (Firmicutes), Candidatus Bacilloplasma (Tenericutes), and Dysgonomonas (Bacteroidetes) were the “indigenous” flora of the crab. In the network‐related analysis with the environment, we found that as the culture time increased, the effect of environmental microorganisms on the intestinal microbes of crabs gradually decreased, and the four “indigenous” bacteria were always unaffected by the environmental microorganisms. The results of this study identified the core bacteria of the crab and, for the first time, studied the relationship between intestinal environmental microorganisms, which will aid the practical production of crabs and will promote research into the relationship between specific bacteria and the physiological metabolism of crabs.
A change in the bacterial community of spider mites decreases fecundity on multiple host plants
Authors: Zhu Yu‐Xi , Song Yue‐Ling , Hoffmann Ary A. , Jin Peng‐Yu , Huo Shi‐Mei , Hong Xiao‐Yue 
Published: October 2018

AbstractBacterial symbionts may influence the fitness of their herbivore hosts, but such effects have been poorly studied across most invertebrate groups. The spider mite,Tetranychus truncatus,is a polyphagous agricultural pest harboring various bacterial symbionts whose function is largely unknown. Here, by using a high‐throughput 16S rRNA amplicon sequencing approach, we characterized the bacterial diversity and community composition of spider mites fed on five host plants after communities were modified following tetracycline exposure. We demonstrated that spider mite bacterial diversity and community composition were significantly affected by host plants and antibiotics. In particular, the abundance of the maternally inherited endosymbiontsWolbachiaandSpiroplasmasignificantly differed among spider mites that were reared on different plant species and were completely removed by antibiotics. There was an overall tendency for daily fecundity to be lower in the mites with reduced bacterial diversity following the antibiotic treatment. Our data suggest that host plants and antibiotics can shape spider mite bacterial communities and that bacterial symbionts improve mite performance.
Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome
Authors: Haschka David , Volani Chiara , Stefani Ambra , Tymoszuk Piotr , Mitterling Thomas , Holzknecht Evi , Heidbreder Anna , Coassin Stefan , Sumbalova Zuzana , Seifert Markus , Dichtl Stefanie , Theurl Igor , Gnaiger Erich , Kronenberg Florian , Frauscher Birgit , Högl Birgit , Weiss Guenter 
Published: October 2018

ABSTRACTBackgroundRestless legs syndrome is a sensorimotor neurological disorder of the limbs that impairs quality of life and disturbs sleep. However, there has been progress in understanding the disease involving the dopaminergic system as well as iron metabolism. The exact pathophysiological mechanisms of restless legs syndrome remain elusive. We tried to elucidate the underlying mechanisms in iron metabolism in restless legs syndrome subjects on a systemic, cellular, and mitochondrial level.MethodsWe conducted a study prospectively recruiting 168 restless legs syndrome patients and 119 age‐matched healthy controls focusing on iron metabolism using human monocytes as surrogates.ResultsEvaluation of systemic iron metabolism parameters in the circulation showed no significant difference between patients and controls. We observed a significant reduction in mRNA levels of heme oxygenase 1 and mitochondrial iron genes like mitoferrin 1 and 2 in monocytes isolated from restless legs syndrome patients, indicating mitochondrial iron deficiency. Interestingly, we also observed reduced expression of iron regulatory protein 2 along with impaired activity of mitochondrial aconitase and reduced mitochondrial superoxide formation in restless legs syndrome subjects. Along this line, patients had reduced mitochondrial respiratory capacity that improved in restless legs syndrome subjects under treatment with dopaminergic drugs compared with untreated patients.ConclusionsOur data suggest that restless legs syndrome is linked to mitochondrial iron deficiency and associated impairment of mitochondrial function. This is partly corrected by treatment with dopaminergic drugs compared with untreated patients, which may be linked to an effect of dopamine on cellular iron homeostasis. © 2018 International Parkinson and Movement Disorder Society
Unidirectional H‐shaped slot antenna backed by a shallow cylindrical cavity for the 5.8 GHz ISM band
Authors: Pazin Lev , Leviatan Yehuda 
Published: October 2018

AbstractA compact slot antenna backed by a shallow cylindrical cavity for high‐gain unidirectional radiation in the 5.8 GHz ISM is presented. The antenna has a 96% efficiency, 8 dBi gain, 12 dB front‐to‐back ratio, and a −10 dB impedance bandwidth of 7.5%. A prototype of the antenna was fabricated and measured and the measurement results were verified against the simulated ones.
Ultrafast 3D Bloch–Siegert B‐mapping using variational modeling
Authors: Lesch Andreas , Schlöegl Matthias , Holler Martin , Bredies Kristian , Stollberger Rudolf 
Published: October 2018

PurposeHighly accelerated B‐mapping based on the Bloch–Siegert shift to allow 3D acquisitions even within a brief period of a single breath‐hold.Theory and MethodsThe B dependent Bloch–Siegert phase shift is measured within a highly subsampled 3D‐volume and reconstructed using a two‐step variational approach, exploiting the different spatial distribution of morphology and B‐field. By appropriate variable substitution the basic non‐convex optimization problem is transformed in a sequential solution of two convex optimization problems with a total generalized variation (TGV) regularization for the morphology part and a smoothness constraint for the B‐field. The method is evaluated on 3D in vivo data with retro‐ and prospective subsampling. The reconstructed B‐maps are compared to a zero‐padded low resolution reconstruction and a fully sampled reference.ResultsThe reconstructed B‐field maps are in high accordance to the reference for all measurements with a mean error below 1% and a maximum of about 4% for acceleration factors up to 100. The minimal error for different sampling patterns was achieved by sampling a dense region in k‐space center with acquisition times of around 10–12 s for 3D‐acquistions.ConclusionsThe proposed variational approach enables highly accelerated 3D acquisitions of Bloch–Siegert data and thus full liver coverage in a single breath hold.
Muscle weakness and functional disability in patients with myasthenia gravis
Authors: Vinge Lotte , Jakobsen Johannes , Andersen Henning 
Published: October 2018

ABSTRACTIntroduction: Muscle weakness and functional disability have not been evaluated in a population‐based study of patients with myasthenia gravis (MG). Methods: All patients with MG in a well‐defined catchment area were identified in the Danish National Patient Registry. Of the 175 eligible patients, 90 participated and were studied using MG‐specific scales, isometric dynamometry, and functional tests. Fifty age‐ and sex‐matched subjects served as controls. Results: Muscle strength was reduced by 13%, 21%, and 12% for shoulder abduction, knee extension, and ankle extension, respectively (P < 0.05). Chair stand and 400‐meter walking were impaired by 24% and 23%, respectively (P < 0.05). Muscle strength and functional performances were related to MG‐specific scales. Discussion: MG patients have moderately reduced isometric muscle strength and impaired physical performance. Muscle weakness and functional tests relate closely to MG‐specific scales, suggesting that dynamometry and functional tests can be used to monitor MG patients and as efficacy parameters in clinical trials. Muscle Nerve 59:218–223, 2019
Etiology of nocturia response in men with diminished bladder capacity
Authors: Epstein Matthew R. , Monaghan Thomas , Weiss Jeffrey P. 
Published: October 2018

AimsTo test the hypothesis that patients with nocturia owing to diminished global or nocturnal bladder capacity improve via increased bladder capacity.MethodsThis is a retrospective analysis of voiding diaries completed at a VA urology clinic between 2008–2017. Inclusion required patients aged at least 18 years, male, undergoing treatment for nocturia, and having completed at least two 24‐hour voiding diaries ≥1 month apart. Patients were divided into two cohorts: responders (any decline in nocturia) and non‐responders (no change or any increase in nocturia). Patients were further sub‐stratified as having low global bladder capacity (maximum voided volume [MVV] <200 mL) versus low nocturnal bladder capacity (nocturnal maximum voided volume [NMVV] <200 mL and MVV ≥200 mL). Wilcoxon rank‐sum was applied with a Bonferroni correction to test significance.ResultsForty pre‐ and post‐treatment diaries from 27 patients, and 19 pre‐ and post‐treatment diaries from 17 patients were identified as having low global and low nocturnal bladder capacity, respectively. Nocturia responders with low global bladder capacity demonstrated significant decline compared to non‐responders in nocturnal urine volume (NUV) (−140 vs +75, P < 0.01) and nocturnal bladder capacity index (NBCi) (−0.59 vs +0.23, P < 0.01). Patients with low nocturnal bladder capacity similarly demonstrated decreased NUV (−30 vs +160, P = 0.04) and NBCi (−1.4 vs +0.33, P < 0.01). There was no significant change in MVV or NMVV for either group.ConclusionsTreatment directed at lowering nocturnal urine production and enabling patients to consistently void at capacity is a rational strategy to treat nocturia in patients with low bladder capacity.