bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) Guidelines: An international Delphi consensus study
Authors: Pronovost-Morgan Chloé , Greenway Kyle , Roseman Leor 
Published: November 2024

Abstract

Background
Psychedelic substances exhibit complex interactions with the ‘set and setting’ of use, i.e., the internal state of the user and the external environment in which a psychedelic experience takes place. Despite the known importance of these contextual variables, psychedelic research has suffered from methodological weaknesses in reporting extra-pharmacological factors and from a lack of consensus regarding their relative importance.
Methods
The study aimed to generate consensus-based guidelines for the reporting of settings in psychedelic clinical research, according to a diverse international group of psychedelic researchers, clinicians, and past trial participants. We conducted a large international Delphi consensus study composed of four iterative rounds of quasi-anonymous online surveys and facilitated debates.
Findings
Eighty-nine experts from 17 countries initially identified hundreds of potentially important psychedelic setting variables. These 770 responses were synthesized into 49 distinct items that were then rated, debated, and refined in subsequent rounds. The process resulted in 30 extra-pharmacological variables reaching pre-defined consensus thresholds: rated “important” or “very important” for reporting by at least 70% of experts. These items compose the Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) guidelines, categorized into: physical environment, dosing session procedure, therapeutic framework and protocol, and subjective experiences. Emergent study findings reveal significant ambiguities in current conceptualizations of set and setting.
Interpretation
The ReSPCT guidelines and its accompanying explanatory document provide a new standard for the design and documentation of extra-pharmacological variables in psychedelic clinical research. Drug-context interactions warrant further attention to ensure the methodological rigor of psychedelic research.
Funding
Societal Engagement Seed Fund, Imperial College London.
Allelic variation and duplication of the dmrt1 were associated with sex chromosome turnover in three representative Scatophagidae fish species
Authors: Jiang Dongneng , Huang Yuan-Qing , Zhang Xinhui , Bian Chao , Jiao Kai-Zhi , Zhang Lin , Huang Yu , Yang Wei , Li Yu , Shi Gang , Huang Yang , Tian Changxu , Chen Huapu , Deng Si-Ping , Zhu Chun-Hua , Shi Qiong , Li Guang-Li 
Published: November 2024

Abstract

With known candidate sex-determining genes (male-specific dmrt1Ys), fish species of the family Scatophagidae are good models for studying sex chromosome evolution. Here, we analyzed sex chromosome turnover events in three representative fish species from two genera of the family Scatophagidae that have diverged 12.8 million years ago (Mya). Scatophagus argus and Sc. tetracanthus possess dmrt1Ys that arose from allelic variation before they diverged 7.2 Mya, and their loci are truncated dmrt1ΔX. The Y chromosome (Chr1) of Sc. tetracanthus is the result of the fusion of the original Y chromosome (Chr4) with an autosome (Chr13). The Selenotoca multifasciata dmrt1Y arose from a duplication of dmrt1 on Chr4 and then translocated to the new Y chromosome (Chr18). The different evolutionary trajectories of the dmrt1Ys were accompanied by sex chromosome turnover in these three species. The sex chromosomes of the Scatophagidae family have evolved rapidly, but not randomly.
The Impact of Using DME as a Substitute for LPG in Indonesian Economy
Authors: Setiya Banu , Hartono Djoni 
Published: November 2024

AbstractIn order to reduce the import ratio and high budget needs for energy subsidies, the government of Indonesia is currently developing DME production to replace LPG as fuel in cooking activities. From various previous studies, the policy of using DME not only requires a relatively expensive cost but also has the potential to disrupt health and endanger environmental sustainability due to the use of large amounts of fossil energy from coal. This study aims to examine the impacts of DME policy on the Indonesian economy using the CGE method, 2019 SAM data and two forms of shocks: (i) Decreasing LPG imports and (ii) Reallocating the subsidies budget. DME will have a positive impact on the economy, trigger growth in the productivity of various sectors and encourage employment, but only in the short run. The results of the study in the long run show negative implications even though the percentages are relatively low and not significant. Keywords: CGE, DME, Energy Subsidies, Import, LPG
Benefits and Risks of AI in Health Care: Narrative Review
Authors: Chustecki Margaret 
Published: November 2024

Background
The integration of artificial intelligence (AI) into health care has the potential to transform the industry, but it also raises ethical, regulatory, and safety concerns. This review paper provides an in-depth examination of the benefits and risks associated with AI in health care, with a focus on issues like biases, transparency, data privacy, and safety.

Objective
This study aims to evaluate the advantages and drawbacks of incorporating AI in health care. This assessment centers on the potential biases in AI algorithms, transparency challenges, data privacy issues, and safety risks in health care settings.

Methods
Studies included in this review were selected based on their relevance to AI applications in health care, focusing on ethical, regulatory, and safety considerations. Inclusion criteria encompassed peer-reviewed articles, reviews, and relevant research papers published in English. Exclusion criteria included non–peer-reviewed articles, editorials, and studies not directly related to AI in health care. A comprehensive literature search was conducted across 8 databases: OVID MEDLINE, OVID Embase, OVID PsycINFO, EBSCO CINAHL Plus with Full Text, ProQuest Sociological Abstracts, ProQuest Philosopher’s Index, ProQuest Advanced Technologies & Aerospace, and Wiley Cochrane Library. The search was last updated on June 23, 2023. Results were synthesized using qualitative methods to identify key themes and findings related to the benefits and risks of AI in health care.

Results
The literature search yielded 8796 articles. After removing duplicates and applying the inclusion and exclusion criteria, 44 studies were included in the qualitative synthesis. This review highlights the significant promise that AI holds in health care, such as enhancing health care delivery by providing more accurate diagnoses, personalized treatment plans, and efficient resource allocation. However, persistent concerns remain, including biases ingrained in AI algorithms, a lack of transparency in decision-making, potential compromises of patient data privacy, and safety risks associated with AI implementation in clinical settings.

Conclusions
In conclusion, while AI presents the opportunity for a health care revolution, it is imperative to address the ethical, regulatory, and safety challenges linked to its integration. Proactive measures are required to ensure that AI technologies are developed and deployed responsibly, striking a balance between innovation and the safeguarding of patient well-being.
Development of interactive e-modules with stem approach using canva application to improve students' critical thinking ability in physics learning
Authors: Yunita Yunita , Diani Rahma , Noperi Hendri , Velina Yessy 
Published: November 2024

This study aims to determine the feasibility, response, and improvement of students' critical thinking skills towards learning using e-modules. This type of research is development research using Sugiyono's development model with 10 stages, namely potential and problems, data collection, product design, design validation, design revision, product trials, product revisions, usage trials, final product revisions, and mass production. The research was conducted at SMPN 6 Krui and MTsN 2 Lampung Tengah, with the research subjects being 88 students in class VIII. The instruments used in this study were validation sheets, student response questionnaire sheets and critical thinking ability tests. Based on the results of the study, the validation results of interactive e-modules with the STEM approach from material experts amounted to 92% and media experts amounted to 90% with the category very feasible to use in learning. The response of students to the attractiveness of the e-module in the field trial was 90% and the educator was 89% with a very interesting category. The results of improving students' critical thinking skills obtained N-gain 0.71 including the high category. Thus the e-module developed is categorized as feasible to use as an alternative physics teaching material
estudo sobre a formação do bibliotecário e a prática no serviço de referência
Authors: Lima Gracirlei Maria de Carvalho 
Published: November 2024

O artigo apresenta um estudo sobre o currículo de biblioteconomia, com foco no serviço de referência, e prática do profissional do citado serviço. O objetivo é o de compreender qual é a influência do currículo de biblioteconomia na prática cotidiana do bibliotecário de referência, de forma a verificar como se dá tal prática profissional frente ao aprendizado teórico da graduação em biblioteconomia. Para tanto, optou-se por uma pesquisa qualitativa, na qual foi realizada uma entrevista semiestruturada em profundidade com oito bibliotecários de bibliotecas públicas, escolares, universitárias e especializadas, que atuam no setor de referência. Adotou-se, ainda, a observação dos participantes no próprio local de trabalho. Os resultados apontaram que as disciplinas cursadas na graduação têm pouca influência na prática, e há outros fatores considerados importantes, como os estágios e a experiência da prática diária. Contudo, com a observação, verificou-se que teorias são aplicadas à prática, o que é notável por meio do atendimento diferenciado e mais qualificado do bibliotecário de referência.
Agir comunicativo, competência comunicativa e ações de informação
Authors: Lima Clóvis Ricardo Montenegro de , Fischer Günther Helen , Rebelo Maia Mariangela 
Published: November 2024

Neste artigo discute-se a relação entre agir comunicativo, nos termos da teoria do agir comunicativo, e as ações de informação, nos termos dos estudos de González de Gómez. Essa discussão passa pelo conceito de competência comunicativa, tal qual desenvolvido por Habermas, pela discussão crítica das abordagens cognitivistas, construtivistas e pragmáticas da informação. Habermas em sua guinada linguística busca entender a socialização, a formação de grupos sociais e a construção da sociedade a partir das interações mediadas pela linguagem. O agir comunicativo tem a função de criar vínculos sociais. Habermas desenvolve o conceito de competência comunicativa, como algo maior do que a capacidade linguística de se expressar e de representar as coisas e o mundo da vida. A competência comunicativa está relacionada também a função da linguagem para socialização e integração social, relacionada a intersubjetividade entre ego e alter.A informação é significação compartilhada, construção de acordos de representação das coisas e do mundo da vida e parte do agir comunicativo. Pode-se pensar a ação de informação no quadro da competência comunicativa como parte do agir comunicativo, construção de acordos de representação e compartilhamento de significado. Conclui-se que a ação de informação é intersubjetiva e não pode se reduzir a objetivação do outro, seja como emissores e receptores, seja como usuário.
sistematização como um recurso para o planejamento da prática da leitura literária no sistema socioeducativo
Authors: Ferraz Dos Santos Bianca , Vargas Alencar Patrícia 
Published: November 2024

Este artigo focaliza o planejamento de ações para a leitura literária em ambiente de privação de liberdade. Objetiva discutir a sistematização da prática da leitura para a formação leitora de adolescentes que cumprem medidas socioeducativas. Parte da revisão da literatura de pesquisas que já investigaram os impactos das práticas de leitura na formação do sujeito. Insere-se no escopo teórico da Biblioteconomia e áreas afins que abordam os conceitos de mediação e leitura literária. Configura-se como uma pesquisa descritiva. Indica a sistematização como uma prática que auxilia no planejamento de ações para a leitura que favorecem a formação do leitor literário que se encontra em contexto de crise.
Palavras-chave: mediação da leitura; sistematização; ambiente de crise.
Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes
Authors: Roshandel Delnaz , Spiliopoulou Athina , McGurnaghan Stuart J. , Iakovliev Andrii , Lipschutz Debby , Hayward Caroline , Bull Shelley B. , Klein Barbara E.K. , Lee Kristine E. , Kinney Gregory L. , Rewers Marian , Costacou Tina , Miller Rachel G. , McKeigue Paul M. , Paterson Andrew D. , Colhoun Helen M. 
Published: November 2024

Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large meta–genome-wide association studies (GWAS) of C-peptide and AAD in T1D and to identify the HLA allele/haplotypes associated with C-peptide and AAD. A total of 7,252 and 7,923 European individuals with T1D were included in C-peptide and AAD GWAS, respectively. HLA-DQB1*06:02, which is strongly protective against T1D, was associated with higher C-peptide. HLA-DQB1*03:02, HLA-DRB1*03:01, and HLA-A*24:02, which increase T1D risk, were independently associated with younger AAD. HLA-DR3-DR4 haplotype combination, the strongest T1D susceptibility factor, was associated with younger AAD. Outside the HLA region, rs115673528 on chromosome 5 (Chr5) (GABRG2) was associated with C-peptide, and an indel, rs111970692, on Chr15 within CTSH, a known T1D locus, was associated with AAD. Genetically predicted CTSH expression, methylation, and protein levels were associated with AAD. Mendelian randomization analysis suggested that higher levels of pro-cathepsin H reduced AAD. In conclusion, some HLA allele/haplotypes associated with T1D also contribute to variability of C-peptide and AAD. Outside HLA, T1D loci were generally not associated with C-peptide or AAD. CTSH could be a potential therapeutic target to delay development/progression of T1D.

Article Highlights
Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta–genome-wide association studies.
Pengkajian Holistik Pasien Stroke Non-Hemoragik: Sebuah Laporan Kasus
Authors: Suryawan Putra Bayu Pramana , Ni Nyoman Mestri Agustini , Luh Putu Kamelia Lina , I Ketut S. Kapakisan 
Published: November 2024

Stroke merupakan defisit neurologis fokal atau global yang berlangsung akut yang berlangsung lebih dari 24 jam atau menyebabkan kematian tanpa sebab lain selain gangguan vaskular. Stroke Non-Hemoragik merupakan jenis stroke dengan angka kejadian terbanyak di Amerika Serikat. Pada pasien kasus ini, pasien lelaki, 66 tahun, mengeluh lemah separuh tubuh sisi kanan 29 jam sebelum masuh rumah sakit. Pasien dengan riwayat hipertensi dan penyakit jantung tidak terkontrol. Pada pemeriksaan didapatkan paresis nervus VII dekstra supranuklear, paresis nervus XII dekstra supranuklear , hemiparesis flaksid dekstra grade IV . Refleks fisiologis ditemukan menurun pada dekstra. Refleks patologis ditemukan positif pada dekstra, yaitu Hoffmann-Tromner, Babinski, Oppenheim, Chaddock, Gordon, Schaeffer, Stransky, Gonda, Bing. Hasil siriraj score iskemia. Pada elektrokardiografi ditemukan fibrilasi atrium respon ventrikel normal, foto toraks kardiomegali, dan CT-Scan tidak menunjukkan adanya infark. Walaupun CT-Scan tidak menunjukkan infark, diagnosa stroke non-hemoragik tetap ditegakkan dengan pertimbangan onset dan klinis pasien. Penegakan diagnosis stroke non-hemoragik didasarkan pada anamnesis, pemeriksaan klinis neurologis, dan pemeriksaan penunjang. Pada aspek biopsikososial, pasien memiliki masalah pada faktor biologis, psikis, dan sosial. Pada aspek Tri Hita Karana, pasien memiliki masalah pada pawongan. Terapi yang diberikan berupa terapi umum dan khusus. Selama perawatan, pasien mengalami perbaikan yang dilihat dari indeks barthel dan skor NIHSS.
Self-directed learning through gamification of mathematics lessons: Literature review and a framework for enactment
Authors: ONG Eythan Tzeng Junn , TOH Tin Lam 
Published: November 2024

Gamification, or the use of game-like elements for classroom instruction, has been the subject of study by educators. Currently there are no frameworks for enacting gamification in the mathematics classroom. In this paper, we propose a framework for facilitating Mathematics teachers to implement gamification in classrooms. Through gamification, we target to nurture self-directed learners of Mathematics. Our proposed framework is based on a systematic literature review conducted by the researchers. In our proposal, we map the use of various elements of gamification at each phase of learning through to Merrill’s First Principles of Instruction and van Hiele’s Model of Geometric Thinking. An exemplar of a lesson on geometry with the use of the framework is also presented.
The Impact of Quizizz Language Learning App in Improving Students' Listening Skills
Authors: Pratama* Fikran Arendi , Rachman Dzul 
Published: November 2024

This study investigates the influence of the Quizizz Language Learning App on enhancing students' auditory comprehension abilities in vocational institutions. The study employed a pretest-posttest methodology to assess the listening abilities of students both before and after the integration of Quizizz as an instructional tool. The study involved 25 students from SMK 15 Samarinda, who were evaluated using standardized listening tests conducted on the Quizizz platform. The findings demonstrated a noteworthy enhancement in the listening abilities of the pupils, with an average discrepancy of -32.400 points seen between the scores of the pretest and posttest. The results indicate that Quizizz is a valuable instrument for improving auditory abilities in children attending vocational schools. The study highlights the capacity of gamified educational technology to establish captivating and efficient learning settings, therefore enhancing overall language competency. Additional research is advised to investigate the enduring impacts of Quizizz on different linguistic abilities and its relative efficacy compared to other instructional technologies.
AIRCRAFT MAINTENANCE AND NEUROERGONOMICS PRINCIPLES: A SUCCESSFUL TECHNOLOGICAL COMBINATION
Authors: Moura Roque Antônio de , Benevides Karina Daniela Garcia , Benevides Marcello Pereira , Richetto Marco Rogério Silva , Sousa Valter João de , Oliveira Márcia Regina , Silva Messias Borges 
Published: November 2024

Objetivo: Esta pesquisa buscou disseminar a intersecção entre manutenção de aeronaves e princípios neuroergonômicos como um avanço bem-sucedido na busca por maior segurança, eficiência e bem-estar da força de trabalho.
Referencial Teórico: As condições físicas e cognitivas humanas de uma perspectiva neuroergonômica combinadas com atividades de manutenção representam uma abordagem inovadora que visa melhorar a eficiência e a segurança nas operações de diversas atividades de manutenção. É necessária extrema atenção e o erro humano não é tolerado.

Método: A metodologia utilizou literatura recente e publicações técnicas relacionadas ao tema, combinadas com os principais módulos técnicos e bibliotecas da linguagem de manutenção aeronáutica.
Resultados e Discussão: Os resultados obtidos destacam que a neuroergonomia, ao analisar fatores cognitivos e emocionais sobre o desempenho humano, melhora as práticas de manutenção, reduzindo erros e aumentando a eficácia com um ambiente mais seguro e saudável para os envolvidos.
Implicações da pesquisa: As implicações práticas e teóricas desta pesquisa mostram que a combinação de princípios neuroergonômicos em atividades de manutenção pode minimizar os riscos inerentes à sua execução.
Originalidade/Valor: Este estudo contribuiu para disseminar princípios neuroergonômicos que visam respeitar os limites físicos e cognitivos da força de trabalho para atingir zero não conformidades nas atividades de manutenção.
Environment in Industry 4.0: Applicability of Biotechnology as a Tool for Sustainability and Innovation
Authors: Lutzer Anderson Vinicios Branco , Mueller Airton Adelar , Oliveira Tarcisio Dorn de 
Published: November 2024

Objective: The objective of this research was to analyze the applicability of biotechnology as a tool for sustainability and innovation in industry 4.0.

Methodology: The methodology adopted consisted of a bibliographic survey carried out on academic platforms such as SciELO, Scopus and Google Scholar, in addition to Brazilian repositories such as CAPES and BDTD. The research included skimming and an analysis of selected materials, addressing both conceptual and practical aspects of biotechnology in industry.

Results and data analysis: The results revealed the evolution of the relationship between human beings and the environment, highlighting the growing awareness of sustainability and the importance of urgent actions. Industry 4.0, in turn, represents the integration of advanced technologies that transform factories into connected and efficient environments, focusing on automation, big data and personalization. Biotechnology has proven essential, using living organisms to develop sustainable products and processes, with significant advances in the areas of health, agriculture and environmental preservation. The intersection between biotechnology and Industry 4.0 allows for the implementation of more sustainable agricultural practices, personalized medical treatments, biofuel production and bioremediation, although it also raises ethical and safety concerns. The conclusion highlights that biotechnology plays a crucial role in promoting sustainability and innovation, offering solutions that optimize processes and reduce environmental impacts. However, challenges such as regulations and ethical issues need to be addressed. Collaboration between governments, industries and research institutions is vital to maximize the benefits and ensure a safe and responsible application of these technologies, thus being able to positively influence the future of the industry towards a more sustainable and efficient production model.

Final considerations: In conclusion, the research revealed that the intersection between biotechnology and Industry 4.0 is fundamental to promoting sustainability and innovation. Biotechnology offers sustainable solutions in areas such as healthcare, agriculture and environmental preservation, while Industry 4.0 enables optimization and efficiency through digitalization and automation. However, ethical and regulatory challenges must be addressed. Collaboration between governments, industries and research institutions is crucial to ensure the safe and responsible application of these technologies, shaping a more sustainable and efficient industrial future.