bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids
Authors: de Carvalho Priscila Goes Camargo , Ribeiro Jhonatan Macedo , Garbin Renata Perugini Biasi , Nakazato Gerson , Yamada Ogatta Sueli Fumie , de Fátima Ângelo , de Lima Ferreira Bispo Marcelle , Macedo Fernando 
Published: December 2018

Background:Thiohydantoins are an important class of heterocyclic compounds in drug discovery since they are related to a wide range of biological properties including antimicrobial activity.Objective:The objective of this study was to synthesize a series of thiohydantoins derived from Laminoacids and to evaluated their inhibitory effect on the growth of Gram-negative and Grampositive bacteria.Methods:All title compounds were synthetized by reaction of L-amino acids with thiourea or ammonium thiocyanate. Their antimicrobial activities were evaluated against bacterial strains by broth microdilution assays. The time-kill kinetics, the antibiofilm activity and the cytotoxicity to mammalian cells were determined for the compound that exhibited the best antimicrobial profile (1b).Results:Eleven thiohydantoins were readily obtained in good yields (52-95%). In general, thiohydantoins were more effective against Gram-positive bacteria. Compound 1b (derived from Lalanine) showed the best antibacterial activity against Staphylococcus epidermis ATCC 12228 and S. aureus BEC 9393 with MIC values of 940 and 1921 µM, respectively. The time-kill kinetics demonstrated time-dependent bactericidal effect in both strains for this derivative. Besides, 1b also exhibited antibacterial activity against biofilms of S. epidermidis ATCC 12228, leading to a 40% reduction in their metabolic activity compared to the untreated control. No cytotoxicity of 1b to mammalian cells was observed at MIC values.Conclusion:The data reported herein indicate relevant antimicrobial activity of thiohydantoins derived from L-aminoacid, mainly 1b, as potential pharmacophore to guide further chemical modification aiming at the search for new and improved antimicrobial agents.
Major Depressive Disorder in Neuroimaging: What is Beyond Fronto-limbic Model?
Authors: Lai Chien-Han 
Published: December 2018

Background:The major depressive disorder (MDD) is a chronic illness with major manifestations in cognitive, social and occupational functions. The pathophysiological model is an intrigue issue for scientists to understand the origin of MDD.Objective:In the beginning, the cortico-limbic-striato-pallidal-thalamic model has been proposed to link the clinical symptoms with the abnormalities in brain structure and function. However, the model is still evolving due to recent advances in the neuroimaging techniques, especially for functional magnetic resonance imaging (fMRI). The recent findings in the fMRI studies in MDD showed the importance of fronto-limbic model for the modulations between cognitive function and primitive and negative emotions.Method:This review will focus on the literature of fMRI studies in MDD with findings not in the fronto-limbic structures.Results:Additional regions beyond the fronto-limbic model have been observed in some literature of MDD. Some regions in the parietal, temporal and occipital lobes have been shown with the alterations in gray matter, white matter and brain function. The importance of sensory detection, visuospatial function, language reception, motor response and emotional memories in these regions might provide the clues to understand the cognitive misinterpretations related to altered reception of outside information, behavioral responses related to biased cognition and emotional memories and clinical symptoms related to the significant alterations of interactions between different brain regions.Conclusion:Future studies to establish a more comprehensive model for MDD will be warranted, especially for the model beyond the fronto-limbic structures.
A Scoping Review of Joint Protection Programs for People with Hand Arthritis
Authors: Bobos Pavlos , Nazari Goris , Lalone Emily A , Ferreira Louis , Grewal Ruby , MacDermid Joy C 
Published: December 2018

Background:Joint Protection (JP) can be enhanced by incorporating recent evidence and innovations in collaboration with people with hand arthritis to be salient, useful and effectively implemented.Objective:The purpose of this study is to map the current research on JP principles and guide future research on JP programs for the management of hand arthritis.Methods:A search was performed in 4 databases (PubMed, EMBASE, Google SCHOLAR, CINHAL) from January 1990 to February 2017. A Grey literature was also conducted through the Google web search engine. A combination of search terms was used such as hand osteoarthritis, rheumatoid arthritis, joint protection and/or self-management strategies.Results:Our search found 8,788 citations in which 231 articles were deemed relevant and after duplication 111 articles were retrieved for a full-text review. In total, 40 articles were eligible for data extraction. The majority of the articles were randomized controlled trials (RCTs), systematic reviews and overviews of reviews that investigated joint protection for hand arthritis. Joint protection was tested mostly in rheumatoid arthritis (RA) population and to a lesser extent on hand osteoarthritis and was provided mainly by an occupational therapist.Conclusion:This review synthesized and critically examined the scope of JP for the management of hand arthritis and found that RCTs, systematic reviews and overviews of reviews constituted two-thirds of the current body of literature. Furthermore, it identified a lack of clarity regarding the specific elements of joint protection programs used in clinical studies.
Role of Biplane Double Supported Screw Fixation For Fracture Neck Femur In Elderly Population: A Prospective Study
Authors: Kalia Anoop , Singh Jagdeep , Ali Nasir 
Published: December 2018

Introduction:The treatment of fracture neck femur varies according to the age of patient, the displacement of fracture fragments and the duration of the fracture. Various treatment options available for elderly are screw fixation, hemiarthroplasty and total hip arthroplasty.Materials and Methods:This is a prospective study done at authors institutes between January 2014- December 2016. 30 patients aged more than 50 years who sustained fracture neck femur were included in the study. 3 patients were lost to follow up and 2 patients died due to medical comorbidities. Out of the 25 remaining patients, 17 were males and 8 were females and they were operated by the biplane double supported screw fixation method (BDSF TECHNIQUE) and were followed up for a period of two years. The final Harris Hip Score at the last follow up was calculated.Results:Out of the 25 patients, the union was achieved in all the patients. The mean duration of union was 10 weeks. 1 patient had progressive femoral head resorption due to chondrolysis resulting in antalgic gait and unbearable pain and underwent total hip arthroplasty. The mean harris hip score was 81.2Conclusion:In elderly patients with osteoporosis and in those patients who can not afford arthroplasty or in those patients where arthroplasty is contraindicated, BDSF method is an alternate method for fixing fracture neck femur.
A Case Report: Custom Made Porous Titanium Implants in Revision: A New Option for Complex Issues
Authors: Burastero Giorgio , Cavagnaro Luca , Chiarlone Francesco , Innocenti Bernardo , Felli Lamberto 
Published: December 2018

Background:
Bone loss management is considered one of the most difficult challenges for orthopaedic surgeon. In massive bone defects, few surgical options are available and they do not offer a reliable or optimal solution for knee reconstruction.

Objective:
The aim of this paper is to present and justify a new custom-made approach for complex metadiaphyseal bone defects management in knee revision surgery.

Methods:
We report a case of a 66-year-old woman who underwent a staged left total knee arthroplasty revision for infection with Anderson Orthopaedic Research Institute classification III uncontained femoral and tibial metadiaphyseal bone defects following five prior surgeries. Along with a case discussion, we describe clinical and radiological outcomes of 3 similar patients treated with this new custom-made device.

Results:
To manage these problems, we developed new, custom porous titanium devices for both femoral and tibial reconstruction tailored to a patient’s specific bone loss. Since, 2014, we treated four cases using custom-made porous titanium cones and we had optimal clinical and radiological results, with no instances of loosening, component migration, or mismatches between preoperative planning and intraoperative findings.

Conclusion:
In extremely selected cases, this new device can be considered a possible and viable surgical step between “off the shelf” reconstruction implants and knee substitution with a tumor megaprosthesis.
Perengkahan n-Butana Menggunakan Katalis Nanopartikel Zeolit Alam Klaten
Authors: Kurniawan Teguh , Muraza Oki 
Published: December 2018

Increasing demand on olefins, high energy consumption of thermal cracking and oil depletion are the driving force to find new process to produce olefins. Catalytic cracking of n-butane is promising route to produce olefins. In this paper, we synthesized nanoparticle from natural zeolites by ball milling-recrystallization method and studied the effect of acid dealumination over the nanozeolites on the catalytic properties. Particle size was evaluated visually by using scanning electron microscope. X-Ray Diffraction analysis was performed to study zeolites phase and its crystallinity. Acid dealumination effect over nanosized mordenite on the acidity were evaluated by ammonia TPD and pyridine FTIR. Textural properties of zeolites were characterized by nitrogen physisorption at -196 oC. The catalysts were tested in a fixed bed reactor for n-butane cracking to olefins product. Various temperature conditions were applied ranging from 350 oC to 650 oC for n-butane cracking in a fixed bed reactor. Conversions of n-butane were 15% and 90% at 350 oC and 650 oC, respectively. Selectivity to olefins was increase from 1% at 350 oC to 47% at 650 oC.
Assessment of Factors Affecting the Foreign Investment Attraction in Iran
Authors: Mohammadi Fereshteh Molla 
Published: December 2018

Abstract
Foreign investment is a critical development strategy. The aim of the study was to investigate the factors affecting the attraction of foreign investment in Iran. The statistical population included foreign investment companies covered by the Foreign Investment Promotion and Protection Act and some experts from investment licensing executive agencies in Tehran province. A total of 400 subjects were enrolled in 2014-2017. The data analysis was performed using Kolmogorov-Smirnov test. All foreign investment companies covered by the investment promotion and protection law were studied by sampling. In addition, a non-random sampling method was used at the experts’ level in the operating systems and executive organisations. In the present research, the Cochran formula was used to determine the sample size being 400 subjects. As a result, 550 questionnaires were distributed and completed; finally, 400 questionnaires were received and analysed in a correct and complete manner. Within the framework of the research, the parametric test (t-test) and linear regression were used for data analysis and the hypotheses due to normal distribution. After analysing the data collected from results of the respondents’ responses and based on mathematical and statistical models, the most important factors affecting foreign investment attraction were the economic factor (p<0.001) followed by the social factor (p=0.002), the administrative bureaucracy (p=0.003), cultural factor (p=0.021) and the agent of the state (p=0.031), all of which exhibited a significant relationship. Based on the results, the economic and cultural factors were the most effective parameters affecting foreign investment.
Forecast of Carbon Dioxide Emissions from Energy Consumption in Industry Sectors in Thailand
Authors: Sutthichaimethee Pruethsan , Ariyasajjakorn Danupon 
Published: December 2018

Abstract
The aim of this research is to forecast CO2emissions from consumption of energy in Industry sectors in Thailand. To study, input-output tables based on Thailand for the years 2000 to 2015 are deployed to estimate CO2emissions, population growth and GDP growth. Moreover, those are also used to anticipate the energy consumption for fifteen years and thirty years ahead. The ARIMAX Model is applied to two sub-models, and the result indicates that Thailand will have 14.3541 % on average higher in CO2emissions in a fifteen-year period (2016-2030), and 31.1536 % in a thirty-year period (2016-2045). This study hopes to be useful in shaping future national policies and more effective planning. The researcher uses a statistical model called the ARIMAX Model, which is a stationary data model, and is a model that eliminates the problems of autocorrelations, heteroskedasticity, and multicollinearity. Thus, the forecasts will be made with minor error.
Determination of Tungsten Inert Gas Welding Input Parameters to Attain Maximum Tensile Strength of 316L Austenitic Stainless Steel
Authors: Moi Subhas Chandra , Pal Pradip Kumar , Bandyopadhyay Asish , Rudrapati Ramesh 
Published: December 2018

Abstract
Weld quality mainly depends on the weld bead geometry and mechanical-metallurgical characteristics of the welded joint which has a direct relationship with the type of welding process being used and its input process parameters i.e. welding current, arc voltage, travel speed etc. In the present study, determination of tungsten inert gas (TIG) welding input parameters for achieving maximum tensile strength of 316L austenitic stainless steel is investigated. Box-Behnken design of response surface methodology has been employed to formulate the experimental plan to identify the effect of process parameters on tensile strength. Square butt joint configuration has been made using three factors - three levels of welding input parameters. Joint strength has been evaluated by notch tensile strength (NTS) and Unnotch tensile strength (UTS) method and correlated with microstructure and micro hardness of the weld. The results indicate that gas flow rate has greater influence on both NTS and UTS followed by welding current.
Dinâmica do uso e cobertura da terra no município de Miranda-MS, Pantanal Sul (Analysis of the Natural Vulnerability of the Banabuiú River Basin, with Support of Geotechnology)
Authors: Leite Vanessa Aline Wagner , Rodrigues Lidiane Perbelin , Leite Emerson Figueiredo 
Published: December 2018

O município de Miranda ocupa uma extensão territorial de 5.478,82km localizados entre os paralelos 20° 29’ e 19° 39’ Sul, e meridianos 57° 01’ e 56° 11’ Oeste. Este munícipio foi escolhido como objeto de estudo desta pesquisa por contemplar áreas dos domínios Cerrado e Pantanal, além de remanescentes da Mata Atlântica, estando situado no contexto da bacia do Alto Paraguai. O objetivo deste trabalho foi analisar a dinâmica de uso e cobertura da terra do município Miranda-MS nos anos de 2006, 2011 e 2017 usando o software Spring/Inpe. Durante a pesquisa foram utilizadas imagens dos satélites Landsat 5-TM e 8-OLI, cena 226/74, que foram processadas no Spring 4.3.3. Para atenuar as diferenças existentes entre as imagens de diferentes sensores imageadores foi realizada a correção atmosférica das imagens e para ressaltar os remanescentes florestais do Pantanal, Cerrado e mata Atlântica foi aplicado o Normalized Difference Vegetation Índex (NDVI). Para classificação das imagens foi utilizado o Método híbrido de Moreira (2012) e o classificador empregado foi o Isoseg. As classes adotadas no mapeamento foram adaptadas do IBGE (2013): Cicatriz de Queimada, Remanescentes Florestais, Campo/Pasto, Corpos D’água, Área Urbana – Miranda, Agricultura Irrigada. Os resultados obtidos permitiram aferir a grande influência hidroclimática e do relevo nas mudanças no uso e cobertura da terra observadas, uma vez que anos de seca são favoráveis ao avanço da antropização de áreas naturais e sua consequente fragmentação. A B S T R A C TThe watershed of the Banabuiú River presents a high degree of environmental degradation, caused by poor land use, low social and economic development and excel of the plan and inefficient management of its resources. As a result, the present work aimed to define the support of geotechnologies, a natural fragility and vulnerability of the basin of the Banabuiú river, through the natural susceptibility of the lands to erosive processes in order to contribute to the sustainable development of the basin. The methods used in the research development will follow the adaptation of the methodologies proposed by Crepani (1996 and 2001), who propose an evaluation of the lands according to an integrated analysis of the environment. For that, maps of geology, geomorphology, pedology, vegetation and climate were elaborated. The overlapping of rights in GIS paper generated the basin's natural vulnerability map. It was observed that 34.638% of the basin area is characterized as the average or vulnerable and in 63.38% as moderately stable. It is also possible to observe the high values of the reserve of the perennial rivers and in the margins of the main reservoirs, which represent risks to the river basin.Keywords: susceptibility, water resources, planning and management.
Karakter Agronomi Beberapa Varietas Sorgum pada Lahan Marginal di Aceh Utara
Authors: D Elvira S , Yusuf Muhamad , Maiyuslina Maiyuslina 
Published: December 2018

Penelitian dilaksanakan di Kebun Percobaan Fakultas Pertanian Universitas Malikussaleh dengan ketinggian tempat 18 m dpl dari bulan Nopember 2013 sampai Pebruari 2014. Penelitian menggunakan rancangan acak kelompok non faktorial dengan 3 ulangan. Data menunjukkan bahwa tinggi tanaman dan diameter batang setiap varietas sorgum tidak berbeda nyata pada 30 HST. Hasil yang lebih variatif didapati untuk tinggi tanaman dan diameter batang pada 60 dan 90 HST. Tinggi tanaman pada 60 HST lebih didominasi oleh varietas Numbu yang tidak berbeda nyata dengan varietas UPCA dan CTY-33.Selanjutnya diikuti oleh varietas Kawali yang tidak berbeda nyata dengan varietas. Berat 1000 biji sorgum tertinggi didapati pada varietas CTY-33 yang tidak berbeda nyata dengen varietas Numbu dan UPCA. Selanjutnya diikuti oleh varietas Mandau dan Kawali. Sedangkan untuk berat berangkasan basah juga didominasi oleh varietas CTY-33 yang tidak berbeda nyata dengan varietas UPCA. Diikuti oleh varietas Numbu, Kawali dan Mandau. Berat berangkasan kering tertinggi diperoleh dari varietas CTY-33 dan diikuti oleh varietas UPCA, Kawali, Numbu dan Mandau. Secara umum, varietas CTY-33 unggul dari semua parameter pengamatan.
Karakter Agronomi Jagung Manis Varietas Sugar 75 Akibat Perlakuan Pupuk Kandang Ayam dan Kalium
Authors: Yusuf N Muhammad 
Published: December 2018

Penelitian ini dilaksanakan pada bulan September hingga November 2012 dengan tujuan untuk mengkaji pengaruh aplikasi pupuk kandang ayam dan kalium terhadap karakter agronomi jagung manis. Model rancangan yang digunakan dalam penelitian ini adalah Rancangan Acak Kelompok (RAK) faktorial yang terdiri dari 2 faktor yaitu aplikasi pupuk kandang ayam (A) sebagai faktor pertama yang terdiri dari 4 taraf yaitu A0 (0 Kg/ha), A1 (10 Kg/ha),A2 (15 Kg/ha) dan A3 (20 Kg/ha). Faktor kedua yaitu aplikasi pupuk Kalium (K) yang terdiri dari K0 (0 Kg K2O/ha), K1 (90 Kg K2O/ha), K2 (120 Kg K2O/ha), dan K3 (150 Kg K2O/ha). Hasil penelitian menunjukkan bahwa aplikasi pupuk kandang ayam dan kalium tidak berpengaruh nyata terhadap karakter agronomi jagung manis
Respon Naungan Terhadap Pertumbuhan Dua Varietas Nilam (Pogostemon cablin Benth.)
Authors: Faizin Rusdi , Susila Putra 
Published: December 2018

Tanaman Nilam membutuhkan cahaya yang relatif sedikit, terutama pada awal pertumbuhan setek tanaman. Untuk mejamin pertumbuhan bibit tanaman nilam perlu diberi pelindung, baik pelindung dari tanaman maupun pelindung buatan. Intensitas cahaya yang rendah mampu meningkatkan parameter pertumbuhan tanaman nilam. Penelitian ini bertujuan untuk mengetahui pengaruh naungan terhadap pertumbuhan nilam varietas Tapak Tuan, dan varietas Lhokseumawe. Penelitian ini dilaksanakan di kebun percobaan Fakultas Pertanian Universitas Teuku Umar Meulaboh Kabupaten Aceh Barat pada September 2016 s/d April 2017. Bahan yang digunakan yaitu stek tanaman nilam, paranet 25% (75% cahaya diterima), paranet 50% (50% cahaya diterima), dan tanpa paranet. Pupuk yang digunakan adalah, pupuk organik, Urea, SP36 dan KCl, zat perangsang tumbuh yaitu grow tone. Penelitian ini menggunakan rancangan petak terpisah (split plot design). Petak utama adalah naungan dan anak petak adalah varietas nilam yaitu varietas Tapaktuan dan varietas Lhokseumawe. Adapun parameter yang diamati yaitu tinggi tanaman, diameter pangkal batang, jumlah cabang, jumlah daun dan luas daun. Pemberian naungan 50% memberi pengaruh terhadap tinggi tanaman, diameter pangkal batang, jumlah daun dan luas daun. Sedangkan varietas Lhokseumawe menunjukkan peningkatan pertambahan tinggi tanaman, diameter pangkal batang, jumlah cabang, jumlah daun dan luas daun.
The NHS/HE Forum
Authors: Ayris Paul , Teague Malcolm 
Published: December 2018

This paper discusses the formation of the NHS-HE
Forum by Professor Roland Rosner in 200 I . It looks
at the aims and objectives of the Forum and maps
current progress. The second part of the paper looks
particularly at the NHS-HE Procurement Group and
the later JISC NHS-HE Procurement Group, which are
part of the Forum. These groupings have been partially
successful in conducting joint procurement activity
across the NHS and HE sectors. The publication of Dr
lan Gibson's Parliamentary Report Scientific Publications:
Free for All? is seminal in progressing this joint acrivity.
As of I February 2006, joint membership of the Public
Library of Science has been achieved, but one joint
procurement activity of commercial content has failed.
Further joint procurement is planned, along with a
mapping study of procurement activities and work on
an Athens Account Linking Project. The library and
informatics research componenrs are coming to the
fore with the use of a community-wide survey to
establish the current situation and future plans for
NHS-HE network connectivity and similarly the
Mapping Study of Procurement Practices in the NHS
and HE for content such as e-journals. This is moving
to a more systematic approach than previously. The
attempted joint procurement of selected journals has
two joint aims: to support both research and clinical
practice in the NHS and HE.