bluuebunny/crossref_metadata_2025_split huggingface dataset:
AICM: A Genuine Framework for Correcting Inconsistency Between Large Pharmacogenomics Datasets
Authors: Tom Hu Zhiyue , Ye Yuting , Newbury Patrick A. , Huang Haiyan , Chen Bin 
Published: August 2018

AbstractThe inconsistency of open pharmacogenomics datasets produced by different studies limits the usage of pharmacogenomics in biomarker discovery. Investigation of multiple pharmacogenomics datasets confirmed that the pairwise sensitivity data correlation between drugs, or rows, across different studies (drug-wise) is relatively low, while the pairwise sensitivity data correlation between cell-lines, or columns, across different studies (cell-wise) is considerably strong. This common interesting observation across multiple pharmacogenomics datasets suggests the existence of subtle consistency among the different studies (i.e., strong cell-wise correlation). However, significant noises are also shown (i.e., weak drug-wise correlation) and have prevented researchers from comfortably using the data directly. Motivated by this observation, we propose a novel framework for addressing the inconsistency
between large-scale pharmacogenomics data sets. Our method can significantly boost the drug-wise correlation and can be easily applied to re-summarized and normalized datasets proposed by others. We also investigate our algorithm based on many different criteria to demonstrate that the corrected datasets are not only consistent, but also biologically meaningful. Eventually, we propose to extend our main algorithm into a framework, so that in the future when more data-sets become publicly available, our framework can hopefully offer a “ground-truth” guidance for references.
Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin
Authors: Harker Alyssa J. , Katkar Harshwardhan H. , Bidone Tamara C. , Aydin Fikret , Voth Gregory A. , Applewhite Derek A. , Kovar David R. 
Published: August 2018

ABSTRACTEna/VASP are tetrameric assembly factors that bind F-actin barbed ends continuously while increasing their elongation rate within dynamic bundled networks such as filopodia. We used single-molecule TIRFM and developed a kinetic model to dissect Ena/VASP’s processive mechanism on bundled filaments. Notably, Ena/VASP’s processive run length increases with the number of both bundled filaments and Ena arms, revealing avidity facilitates enhanced processivity. Moreover, Ena tetramers form more filopodia than mutant dimer and trimers in Drosophila culture cells. Finally, enhanced processivity on trailing barbed ends of bundled filaments is an evolutionarily conserved property of Ena/VASP homologs and is specific to fascin-bundled filaments. These results demonstrate that Ena tetramers are tailored for enhanced processivity on fascin bundles and avidity of multiple arms associating with multiple filaments is critical for this process. Furthermore, we discovered a novel regulatory mechanism whereby bundle size and bundling protein specificity control activities of a processive assembly factor.
A Key For Hypoxia Genetic Adaptation In Alpaca Could Be A HIF1A Truncated bHLH Protein Domain
Authors: Daniel Moraga M , Moraga C Fernando A. , Figueroa Felipe 
Published: August 2018

AbstractAnimals exposed to hypoxia, triggers a physiological response via Hypoxia Inducible Factors (HIF1). In this study, we have evidenced the existence of genetic events that caused the loss of most of the bHLH domain in HIF1A proteins borne by Alpaca and other members of the Cetartiodactyla superorder. In these truncate domains, some stop codons are found at identical nucleotide positions in both, Artiodactyls and Cetaceans, indicating that mutations originating the truncated domains occurs before their divergence about 55 million years ago. The relevance of this findings for adaptation of Alpacas to hypoxia of high altitude conditions are discussed.
General Budget Support in Tanzania
Authors: Furukawa Mitsuaki , Takahata Junichiro 
Published: August 2018

Purpose
The purpose of this paper is to analyze late disbursements for service delivery by focusing on donors’ General Budget Support disbursement to Tanzania and on the intergovernmental money flows in Tanzania.

Design/methodology/approach
The authors examined empirical analysis using statistics of intergovernmental transfers in Tanzania.

Findings
This paper shows that such center-local transfers are significantly correlated with the timing of local government expenditures in general and health expenditures in particular. It also shows that development expenditures are more affected than recurrent expenditures by delays in the transfer.

Practical implications
In order to improve service delivery on the ground, the transfers from donors to the central government and from the central government to local governments need to be timely.

Originality/value
The authors examined empirical analysis using statistics of intergovernmental transfers in Tanzania so as to see whether timing of transfers matters or not, which has not been considered thus far.
Short food supply chain between micro/small farms and restaurants
Authors: Paciarotti Claudia , Torregiani Francesco 
Published: August 2018

Purpose
The purpose of this paper is to explore the strength and weakness connected to the implementation of a local food logistics services, designed to facilitate and enable the use of local food among restaurants.

Design/methodology/approach
A total of 60 restaurateurs located in a small Italian city and 100 owners of micro and small-sized farms, located within a 30 km radius from the city, have been interviewed. The collected data have been analysed through descriptive analysis and Kruskal-Wallis and Mann-Whitney U tests for differences between gender, production type and business size.

Findings
The results agree with existing literature: poor communication and an unstructured logistics limit the interaction among actors. However, significant for the purpose, the data show that producers are interested in expanding their market and restaurateurs are interested in a broader supply of local products, and they both open to a logistics service that improves the supply of local food.

Research limitations/implications
The following exploratory study is based on a sample of farmers and restaurants in a specific area so the results could not be generalised in a national/international context.

Practical implications
The logistics service objective is the promotion of a sustainable territory development in support of the social economy values.

Originality/value
The study investigates this issue focussing on a practical solution of local food distribution system among restaurants. The logistics service tends to solve the logistics criticalities maintaining the principles of the short food supply chain.
The role of environmentally conscious purchase behaviour and green scepticism in organic food consumption
Authors: Golob Ursa , Kos Koklic Mateja , Podnar Klement , Zabkar Vesna 
Published: August 2018

Purpose
Despite numerous scholarly attempts, there is a lack of consensus regarding the relevance of various factors used to promote organic food consumption. The purpose of this paper is to assess the impact of environmentally conscious purchase behaviour (ECPB) and green scepticism on organic food consumption. Moreover, the paper examines the indirect impact of attitudinal and contextual forces on organic food consumption (through ECPB).

Design/methodology/approach
The paper develops a conceptual model of organic food consumption. Data were collected through an online survey on a sample of 462 consumers in Slovenia. Structural equation modelling was used to test the hypothesised relationships.

Findings
The findings indicate that ECPB positively and green scepticism negatively affects organic food consumption. In addition, ECPB is positively influenced by personal and social norms, perceived availability and consumer sustainability orientation. Interestingly, the social norms exert the strongest indirect effect on organic food consumption.

Research limitations/implications
This study informs organic food producers and policy makers about the relative importance of ECPB and scepticism for increasing organic food consumption. It also highlights the role of general attitudinal and contextual factors for ECPB and organic food consumption.

Originality/value
The proposed model enables a better understanding of the relevance of ECPB, its antecedents and green scepticism as (direct or indirect) determinants of organic food consumption.
Household food waste quantification: comparison of two methods
Authors: Delley Mathilde , Brunner Thomas A. 
Published: August 2018

PurposeThe purpose of this paper is to quantify household food waste by using two different methods. A comparison of the results highlights a divergence between the perceived contribution to the problem and more objective measurements.Design/methodology/approachSelf-reported quantities, collected by means of a postal survey sent out to a random sample of the French- and German-speaking Swiss population, were compared to extrapolations from a national waste compositional analysis report.FindingsThe results of the self-reported survey showed 8.9 kg of avoidable and possibly avoidable household food waste per capita per year, whereas calculations based on the second method resulted in a total of 89.4 kg of mostly avoidable household food waste per capita per year.Research limitations/implicationsThis striking tenfold discrepancy between the two sets of results highlights the extent of under-reporting in self-assessment and speaks in favour of using more objective methods to quantify food waste, building on the example of the second method used in this study.Practical implicationsThe discrepancy highlighted here could be used as a hook in an awareness-raising campaign to highlight everyone’s contribution to the food waste issue and encourage citizens to reconsider their behaviour and adopt recommended behavioural changes.Originality/valueBy highlighting the divergence between self-reported and actual waste management facts and figures, this paper justifies the need to develop measures to encourage citizens to reconsider their attitudes and practices.
How knowledge, attitudes, and beliefs impact dairy anti-consumption
Authors: Allen Shannon , Goddard Ellen , Farmer Anna 
Published: August 2018

Purpose
The purpose of this paper is to examine how individual’s health beliefs, nutrition knowledge (NK) and attitudes towards food technologies play a role in the anti-consumption of dairy products or the consumption of dairy alternatives.

Design/methodology/approach
Self-reported data concerning the consumption of milk, yogurt and dairy products in general were collected online among 1,705 adults in Canada. Also included in the survey instrument were measures of NK and health beliefs as well as questions from the food technology neophobia scale. Anti-consumption of milk, yogurt and dairy as well as alternative dairy consumption as a function of these characteristics, in addition to demographic characteristics, is analysed using probit models.

Findings
Individuals who demonstrate resistance to innovations in food technology, those with lower levels of dairy-specific NK, and people who have less belief that dairy avoidance will have negative impacts on their health are more likely to be anti-consumers of milk and/or yogurt. The same is true for dairy products in general with the exception that people with higher levels of dairy-specific NK are more likely to be anti-consumers of dairy products in general.

Originality/value
Inadequate intake of calcium and vitamin D has negative consequences for long-term health. Given that dairy products are the primary source of these nutrients in the Canadian diet, it is important to understand the reasons behind dairy anti-consumption so that appropriate policy measures can be taken to address potential public health issues.
Constructive intercultural contact: yes we can. Introduction of a new concept
Authors: Spijkerman Hans , Benschop Yvonne W.M. , Bücker Joost 
Published: August 2018

PurposeThe purpose of this paper is to introduce the concept of constructive intercultural contact. This concept refers to intercultural contact in which majority as well as minority participants are intercultural effective, i.e. can perceive themselves as comfortable and successful.Design/methodology/approachThis study is based on exploration and review of intergroup, contact, acculturation and organization literature.FindingsFive input elements of constructive intercultural contact are distinguished: responsibility, deliberate choice to postpone judgment, acknowledging the relative relevance of cultural differences, perspective taking and respect. What participants have to do to make constructive intercultural contact in organizations not only possible between colleagues, but also in hierarchical relationships is elaborated by reflection on the interrelation between majority/minority and manager/employee positions in constructive intercultural contact.Originality/valueThis paper contributes to diversity management literature by introducing a new concept which, focusing on the interaction level, explains how participants can make intercultural contact into a comfortable and successful experience for both. Other contributions are the differentiation between majority and minority actors and the elaboration of the complexity of intercultural employee/manager contacts.
Key factors selection approach for SMCDA problem based on GIA model with rate of change
Authors: Luo Dang , Li Haitao , Qian Qicun 
Published: August 2018

Purpose
The purpose of this paper is to construct a key factors selection approach for a class of small-sample multi-factor cross-sectional data analysis (SMCDA) problem, which is very common in productive practice and scientific research, such as coal-bed methane (CBM) content analysis, civil aircraft cost analysis, etc. Key factors selection is an important basic work for SMCDA problem; the proposed method is constructed to improve the accuracy and explanatory of the selected key factors.

Design/methodology/approach
Using grey system theory to solve SMCDA problem is more reasonable under few data and poor information. Therefore, this paper constructs a grey incidence analysis (GIA) model with rate of change to select the key factors of an SMCDA problem. The basic idea of the proposed method is to simulate time series by randomly sorting the selected samples, and to calculate the degree of grey incidence with rate of change by loop iterative algorithm, then to construct the degree matrix of grey incidence with rate of change, and finally by which, to utilise quantitative and qualitative analysis methods to select the key factors.

Findings
The experimental analysis of application cases demonstrates that the key factors of system’s characteristic can be successfully screened out by the proposed method, the results are consistent with actual conditions, and they have a clearer meaning and a better interpretability.

Practical implications
The method proposed in this paper could be utilised to select key factors for such a class of SMCDA problem, which has fewer observation samples (small-sample), which is influenced by a number of factors (multi-factor) and whose observation samples are placed randomly rather than by time (cross-sectional data). Taking the key influence factors of CBM content and the key driving factors of the vulnerability of agricultural drought in Henan as examples, the results proved the feasibility and superiority of this proposed method.

Originality/value
Most of the existing GIA models mainly focus on these classes of issues with time series data or panel data. However, few GIA models take SMCDA problem as the research object. In this paper, the authors develop the GIA model with rate of change according to the characteristics of SMCDA problem, and present some properties and application suggestions of the proposed method.
Exploring customer experiences with robotics in hospitality
Authors: Tung Vincent Wing Sun , Au Norman 
Published: August 2018

PurposeThe purpose of this study is to explore consumer reviews with robotics based on the five dimensions for evaluating user experiences (i.e. embodiment, emotion, human-oriented perception, feeling of security and co-experience), as derived from research in human-robot interactions (HRI).Design/methodology/approachThe study first reviews the five dimensions for evaluating user experiences in HRI and then analyzes user experiences with robotics at four hotels (i.e. Yotel New York, Aloft Cupertino, Henn-na Hotel Japan and Marriott Residence Inn LAX) based on reviews on TripAdvisor, Agoda, Yelp and Booking.com.FindingsThe findings highlight the influence of robotic embodiment and human-oriented perceptions on consumer experiences. The findings also suggest that users and robots can co-create novel experiences, with some guests even proactively seeking new opportunities to interact and communicate with robots to develop a certain level of “relationship” with them.Research limitations/implicationsAn understanding of user experiences from HRIs can inform future hospitality and tourism research and management.Practical implicationsThis study contributes to hospitality and tourism management by highlighting current practices with robotics to suggest areas of improvements for enhancing future consumer experiences.Social implicationsConsumer experiences will change rapidly as hospitality and tourism management deploys robotics in the future.Originality/valueThis is one of the early studies in the field to explore consumer experiences with robotics based on the five dimensions for evaluating user experiences from research in HRI. In doing so, this study provides a number of theoretical and managerial implications relevant for hospitality and tourism research and practice.
The reading public in the United Arab Emirates
Authors: Amaize Odekhiren , Buigut Steven 
Published: August 2018

Purpose
The purpose of this paper is to investigate the socioeconomic factors that influence the public’s reading interest in specific genres of literature, as well as what the public actually reads or listens to in the United Arab Emirates (UAE).

Design/methodology/approach
A survey of 1,377 households, consisting of 650 and 727 from Abu Dhabi and Dubai, respectively, was conducted in 2012 as part of the country’s first, and to date only, comprehensive Survey of Public Participation in the Arts. A multivariate probit model is applied to analyze factors that influence interest in reading fiction, religion and spirituality and health and fitness. In addition, factors that influence public’s likelihood to read novels, short stories and poems are also assessed.

Findings
The results indicate that ethnicity, gender and education level significantly influence both the interest in reading, and actual reading habits. For example, while Asian and Western expatriate groups show more interest in fiction and health and fitness literature, Emirati are more likely to read poems. A gender difference is identified with females more likely to read.

Research limitations/implications
The survey focused on regular dwelling units and within a household, family and resident relatives. Hence, it excludes a segment of residents, such as domestic workers and unauthorized migrants.

Originality/value
This is the first study to empirically assess the factors influencing the public’s interest and reading habits across a range of genres of literature in the UAE.
Gender perspective on life insurance demand in Ghana
Authors: Ampaw Samuel , Nketiah-Amponsah Edward , Owoo Nkechi Srodah 
Published: August 2018

Purpose
Against the background that Ghanaians seldom purchase insurance policies, the purpose of this paper is to investigate the determinants of life insurance uptake among male and female household heads in Ghana.

Design/methodology/approach
The study employs data on 775 male and 233 female household heads from the sixth round of the Ghana Living Standards Survey. Adjusted Wald test statistics and logistic regressions are employed for the empirical estimations.

Findings
Results from the adjusted Wald test show that the sampled male household heads significantly differ from their female counterparts in terms of the selected socioeconomic and demographic characteristics. Though ill health status, higher wealth, being self-employed or in wage or salaried employment and residing in either of the three northern regions (upper east, upper west and northern regions) in Ghana broadly affect the demand for life insurance among both male and female heads, other factors are peculiar to either parties. Particularly, whereas female heads who are married and those with more dependants have a higher propensity of purchasing life insurance policies, their male counterparts with higher education are more likely to buy life insurance policies.

Research limitations/implications
The paper adds to the paucity of cross-sectional studies on life insurance demand in Africa.

Practical implications
Based on the explored determinants, insurers could better regulate the purchase of their products by taking into consideration the gender differences to maximize their sales and enhance economic growth and development.

Originality/value
This paper explores the gender dynamics in the determinants of life insurance demand in a developing country, Ghana. Besides, findings from related literature are reported to be mixed. Though the current paper is not wholly nationally representative, it utilizes data from across all the ten administrative regions of Ghana. To the best of the authors’ knowledge, no prior study has been conducted in this manner.
Determinants of enrolment in the NHIS for women in Ghana – a cross sectional study
Authors: Kusi Anthony , Fenny Ama , Arhinful Daniel Kojo , Asante Felix Ankomah , Parmar Divya 
Published: August 2018

Purpose
The National Health Insurance Scheme (NHIS) was introduced in 2005 to provide equitable access to healthcare. Furthermore, concessions were made for pregnant women, yet inequities in access continue to exist. The purpose of this paper is to explore whether dimensions of social exclusion explain why some groups of women are not benefitting from the scheme.

Design/methodology/approach
Data were collected from 4,050 representative households in five districts. Logistic regression is used to examine the factors that determine enrolment of women under the NHIS.

Findings
The study sample consists of a sub-sample of 3,173 women out of whom 58 per cent were insured. The majority (64.9 per cent) of the women were in the reproductive age (15–45 years). The results show that wealth status, age, health status, locality, perception about the quality of care at health facilities and perception of the NHIS, are the key factors that determine enrolment into the scheme.

Practical implications
By conceptualising social exclusion as the multi-dimensional processes driven by unequal power relationships which lead to differential inclusion and exclusion in social systems, the study provides evidence to show that certain groups of women are systemically excluded from participating in the NHIS.

Social implications
With women dominating the informal sector of Ghana’s economy which is often characterised by relatively low incomes, these inequities in access need to be addressed.

Originality/value
Although gender equality incorporates discussions on issues affecting men and women this paper focusses on women in Ghana due to disadvantaged position in which many of them find themselves in terms of access to resources. Almost all of the identified barriers in previous studies have been worsened by gender with women generally facing greater difficulties in accessing adequate care. Few of these papers have taken account the specific health needs and gender-specific constraints of women in the NHIS. The authors aim to fill this gap by using a social exclusion lens to explore whether Ghanaian women (i.e. 15 years and above) are participating in the NHIS and examine the processes by which exclusion occurs and what explains the patterns observed.