bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilisation of teratogenic medicines before and during pregnancy in Australian women
Authors: Raichand Smriti , Pearson Sallie‐Anne , Zoega Helga , Buckley Nicholas A. , Havard Alys 
Published: August 2019

BackgroundGiven the potential hazards of teratogenic medicines, to a fetus exposed in utero, monitoring their use around pregnancy is imperative.AimTo measure utilisation of teratogenic medicines (Therapeutic Goods Administration's category D or X) in women who gave birth in New South Wales, Australia, during pregnancy and the 24 months prior.Materials and MethodsWe used linked population‐based datasets including dispensing and perinatal data for all deliveries in NSW between 2005 and 2012. We included pregnancies among concessional beneficiaries only, with complete ascertainment of dispensing claims. Pre‐pregnancy and during‐pregnancy periods were based on birth dates and gestational age. We determined prevalence of exposure using percent of pregnancies in which women had at least one dispensed teratogenic medicine in three‐month time periods.ResultsThe study included 191 588 pregnancies (145 419 women). Prevalence of exposure to D/X medicines anytime during pregnancy was 2.0% (<20 pregnancies category X), decreasing from pre‐pregnancy (3.8–6.0%) to first trimester (1.5%), further decreasing in second and third trimesters (0.8% and 0.6% respectively). We observed large reductions in antibiotic prevalence but only modest reductions for psychotropics and antilipidemic agents (all category D). Our results suggest higher use of potentially teratogenic medicines (category D) than those strictly contraindicated for use (category X), during pregnancy. Overall, use was higher in the first trimester than the rest of pregnancy. The high prevalence of potentially contraindicated psychotropics in all three trimesters may suggest a higher benefit‐to‐risk ratio and warrants future research focusing on the reasons for their prescribing to pregnant women.
The Moderating Effect of Debates on Political Attitudes
Authors: Brierley Sarah , Kramon Eric , Ofosu George Kwaku 
Published: August 2019

AbstractIn theory, candidate debates can influence voters by providing information about candidates' quality and policy positions. However, there is limited evidence about whether and why debates influence voters in new democracies. We use a field experiment on parliamentary debates during Ghana's 2016 elections to show that debates improve voters' evaluations of candidates. Debates have the strongest effect on partisan voters, who becomemorefavorable toward and more likely to vote for opponent‐party candidates and less likely to vote for co‐partisans. Experimental and unique observational data capturing participants' second‐by‐second reactions to the debates show that policy information was the most important causal mechanism driving partisan moderation, especially among strong partisans. A follow‐up survey shows that these effects persist in electorally competitive communities, whereas they dissipate in party strongholds. Policy‐centered debates have the potential to reduce partisan polarization in new democracies, but the local political context conditions the persistence of these effects.
Polyethylene glycol loxenatide (PEX168) in subjects with renal impairment: A pharmacokinetic study
Authors: Wang Jianwen , Huang Jie , Li Wei , Tang Shiqi , Sun Jian , Zhang Xianming , Liu Jun , Yi Bin , Liu Jishi , Zhang Xingfei , Yang Qian , Yang Xiaoyan , Yang Shuang , Yang Guoping , Zhang Hao 
Published: August 2019

AimsType 2 diabetes mellitus (T2DM) is commonly complicated by renal impairment. Polyethylene glycol loxenatide (PEX168) is a novel long‐acting glucagon‐like peptide‐1 receptor agonist for T2DM. PEX168 pharmacokinetics was studied to identify requirements for dose‐modification in T2DM complicated by renal impairment.MethodsThis was a single‐centre, open‐labelled, parallel‐group, single‐dose, phase I clinical trial of patients with mild and moderate renal impairment, and with or without T2DM. Age‐, sex‐ and body mass index‐matched subjects with normal renal function, and with or without T2DM were recruited as controls. Subjects received a single abdominal subcutaneous injection of PEX168 200 μg. Pharmacokinetic samples were taken at 0, 24, 48, 72, 96, 120, 144, 216, 312, 480, 648 and 720 hours.ResultsTwenty‐three patients were included in the pharmacokinetics analysis. Vz/F and CL/F were lower in the moderate impairment group than in the other groups. The mean t1/2 (163 hours) in the moderate impairment group was prolonged compared to the mild impairment (117 hours) and normal (121 hours) groups. AUC0–inf increased by 13 and 100.7% in patients with mild and moderate renal impairment, respectively. Most adverse events were mild gastrointestinal disorders, with only 1 serious adverse event observed.ConclusionA single dose of 200 μg of PEX168 was in general well tolerated in patients with renal impairment. The in vivo clearance rate of PEX168 in patients with moderate renal impairment is slower than in patients with mild renal impairment and normal renal function and dose adjustment might be required (ClinicalTrials.org #NCT02467790).
Chitinase 3‐like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation
Authors: Kwak Eun Ji , Hong Jung Yeon , Kim Mi Na , Kim Soo Yeon , Kim Seo Hyeong , Park Chang Ook , Kim Kyung Won , Lee Chun Geun , Elias Jack A. , Jee Hye Mi , Sohn Myung Hyun 
Published: August 2019

AbstractBackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by defective skin barrier and Th2 immune responses. Chitinase 3‐like 1 (CHI3L1), also known as breast regression protein 39 (BRP‐39) in mice and human homologue YKL‐40, plays important roles in Th2 inflammation and allergen sensitization. CHI3L1 has been implicated in a variety of diseases including asthma characterized by inflammation, apoptosis and tissue remodelling, but its role in AD remains elusive.ObjectiveThe aim of this study was to investigate the role of CHI3L1 in the development and progression of AD.ResultsWe investigated YKL‐40 levels in the serum and skin of AD patients by ELISA and immunofluorescence, respectively. Using a murine model of AD induced by ovalbumin (OVA), we investigated Th2 immune responses, M2 macrophage activation and skin barrier gene expression using wild‐type (WT) and BRP‐39 null mutant (BRP‐39−/−) mice.YKL‐40 level was significantly increased in serum of AD patients. In addition, both mRNA and protein expression levels of BRP‐39 were higher in OVA‐sensitized WT mice than in control mice. OVA‐sensitized BRP‐39−/− mice showed decreased epidermal thickness, lower total serum IgE, Th2 cytokine levels and CD4+ effector T cell populations than OVA‐sensitized WT mice. Induction of BRP‐39 was dominant in dermal macrophages. BRP‐39 deficiency was found to be involved in M2 macrophage activation. Consistently, the YKL‐40 level in the skin of AD patients was higher than in normal subjects and it was expressed in dermal macrophages. BRP‐39 deficiency attenuated dysregulation of skin barrier and tight junction genes.Conclusions and Clinical RelevanceThese findings demonstrate that CHI3L1 mediates the development of AD induced by OVA, affecting Th2 inflammation, M2 macrophage activation and skin barrier function.
The ethics of genetic engineering and gene drives in conservation
Authors: Sandler Ronald 
Published: August 2019

AbstractThe ethical issues associated with using genetic engineering and gene drives in conservation are typically described as consisting of risk assessment and management, public engagement and acceptance, opportunity costs, risk and benefit distributions, and oversight. These are important, but the ethical concerns extend beyond them because the use of genetic engineering has the potential to significantly alter the practices, concepts, and value commitments of conservation. I sought to elucidate the broader set of ethical issues connected with a potential genetic engineering turn in conservation and provide an approach to ethical analysis of novel conservation technologies. The primary rationales offered in support of using genetic engineering and gene drives in conservation are efficiency and necessity for achieving conservation goals. The instrumentalist ethical perspective associated with these rationales involves assessing novel technologies as a means to accomplish desired ends. For powerful emerging technologies the instrumentalist perspective needs to be complemented by a form‐of‐life perspective frequently applied in the philosophy of technology. The form‐of‐life perspective involves considering how novel technologies restructure the activities into which they are introduced. When the form‐of‐life perspective is applied to creative genetic engineering in conservation, it brings into focus a set of ethical issues, such as those associated with power, meaning, relationships, and values, that are not captured by the instrumentalist perspective. It also illuminates why the use of gene drives in conservation is so ethically and philosophically interesting.
Cave insects with sex‐reversed genitalia had their most recent common ancestor in West Gondwana (Psocodea: Prionoglarididae: Speleketorinae)
Authors: Yoshizawa Kazunori , Lienhard Charles , Yao Izumi , Ferreira Rodrigo L. 
Published: August 2019

AbstractThe divergence date and ancestral distributional area of the psocid subfamily Speleketorinae, which includes taxa with reversed genitalia (female penis and male vagina of Afrotrogla and Neotrogla, tribe Sensitibillini), were estimated. The most basal divergence of the subfamily (between the North American Speleketor and the tribe Sensitibillini) was estimated to have occurred according to the separation between the North American continent and Gondwana, ca. 175 Ma. The most basal divergence of Sensitibillini (between African Afrotrogla + Sensitibilla and Brazilian Neotrogla) was estimated to have occurred according to the split of West Gondwana (separation between the African and South American continents), ca. 127 Ma. The biome of the ancestral distributional area of Sensitibillini (inland of West Gondwana) is believed to be arid to semi‐arid, which might strengthen the reversed sexual selection and then facilitate the origin of preadaptive features related to the evolution of a female penis. All extant Sensitibillini species inhabit carbonatic caves, but geological evidence suggested independent shifts of these genera to the carbonatic cave habitat in the Tertiary/Quaternary.
Resilience Factors and Suicide Risk for a Sample of Transgender Clients
Authors: Edwards Lindsay L. , Torres Bernal Aníbal , Hanley Scotty M. , Martin Shannon 
Published: August 2019

This study explored how individual‐ and community‐based resilience factors operated together in order to reduce risk of suicide for a sample of transgender therapy clients. We collected cross‐sectional survey data from 106 transgender therapy clients at a local community center, including demographic information, experiences of relational support, participants' emotional stability, and risk for suicide. Results from our mediation analysis indicated that high levels of perceived relational support are related to reduced risk for suicide and that this happens by way of a person's emotional stability. Clinical implications for family therapists are discussed based on the significant indirect effect found in this study.
Impact of edema on length of calf circumference in older adults
Authors: Ishida Yuria , Maeda Keisuke , Nonogaki Tomoyuki , Shimizu Akio , Yamanaka Yosuke , Matsuyama Remi , Kato Ryoko , Mori Naoharu 
Published: August 2019

AimCalf circumference, which is a known simple indicator of muscle mass, increases during edema. However, the extent to which edema increases calf circumference in older adults is unclear.MethodsThis retrospective cross‐sectional study included patients aged ≥65 years whose nutritional status was assessed by nutrition support teams. Two different types of matching models in each sex were created according to the presence of edema on the right lower limb. All models were adjusted by age, body height, handgrip strength and performance status. Sarcopenia was diagnosed based on both reduced calf circumference and decline of handgrip strength. The prevalence of sarcopenia was estimated before and after adjustment for increment of calf circumference.ResultsIn total, 2101 patients were included. Multifactor matching models showed that the mean difference in calf circumference between pairs was 1.6 cm (95% confidence interval [CI] 1.1–2.1, P < 0.001) for women and 2.1 cm (95% CI 1.6–2.7, P < 0.001) for men. The propensity score matching model similarly showed a mean difference of 1.6 cm (95% CI 1.1–2.1, P < 0.001) for women and 2.0 cm (95% CI 1.5–2.6, P < 0.001) for men. The prevalence of sarcopenia before and after adjusting for an edema‐related increase in calf circumference was 42.6%/48.6% for women and 35.3%/38.5%–38.7% for men.ConclusionsEdema in the lower limb increased the calf circumference by approximately 2 cm. When using calf circumference to assess muscle mass in patients with edema, the increase in circumference should be subtracted from the baseline circumference for an accurate assessment. Geriatr Gerontol Int 2019; 19: 993–998.
Determinants of remittances in Egypt: Do macroeconomic instability and oil price matter?
Authors: Akçay Selçuk , Karasoy Alper 
Published: August 2019

AbstractEmigration and resulting voluminous remittance inflows have been noticeable features of the Egyptian economy since the 1960s. The main purpose of this study is to investigate the determinants of remittances – primarily the role of both macroeconomic instability and oil price – in Egypt. Using autoregressive distributed lag (ARDL) bounds testing procedure, we estimated a remittance determination equation over the period from 1980 to 2015 and found that: (1) macroeconomic instability in Egypt and increases in international oil prices promote remittances; (2) GDP growth rate in the host countries and depreciation of domestic currency spur remittances; (3) financial development is inversely related to remittances, implying that remittances and financial development are substitutes; (4) GDP growth in the home country is not significantly associated with remittances.
The effect of antibiotic prophylaxis on wound infections after laparoscopic cholecystectomy: A randomised clinical trial
Authors: Guler Yilmaz , Karabulut Zulfikar , Sengul Serkan , Calis Hasan 
Published: August 2019

AbstractThe aim of this study was to determine whether the use of prophylactic antibiotics had any effects on the development of postoperative surgical wound infections between laparoscopic cholecystectomy patients. Patients who received a single dose of prophylactic antibiotics prior to surgery were included in the prophylaxis group, and those who did not receive preoperative and postoperative intravenous and/or oral antibiotics were included in the no prophylaxis group. A total of 206 patients who underwent laparoscopic cholecystectomy were examined; the infection rate in patients who received prophylaxis was 4.5%, while it was 4.2% in the non‐prophylactic group. There was no statistically significant difference between the groups in terms of infection development rates (P > .05). We suggest that antibiotics should not be given for prophylaxis before low‐risk laparoscopic cholecystectomy as there is no statistically significant difference in the rate of postoperative wound infection among patients who were either given or not given prophylaxis.
Ethical dilemmas and legal aspects in contraceptive counselling for women with intellectual disability—Focus group interviews among midwives in Sweden
Authors: Höglund Berit , Larsson Margareta 
Published: August 2019

AbstractBackgroundFew studies have explored ethical and legal issues in contraceptive counselling among women with intellectual disability (ID). This study aimed to gain a deeper understanding of these issues during midwifery contraceptive counselling.MethodThe present authors interviewed 19 midwives in five focus groups in Sweden 2016 – 2017 and analysed data with content analysis.ResultsThe participants expressed that women with intellectual disability have equal right to relationships and sexual expressions, but feared exposure to sexual exploitation/abuse. They experienced ethical dilemmas related to principles of fairness and autonomy, but strived to provide assistance in spite of the women's cognitive impairment, presence of supporting persons and uncertainty of optimal counselling. Organizational support was insufficient.ConclusionsThe midwives experienced ambivalence, uncertainty and ethical dilemmas in their counselling. They were, however, aware of legal aspects and strived for the women's best interest, right to self‐determination and autonomous choices. The participants wanted better professional teamwork and support.
A novel method to monitoring changes in cognitive load in video‐based learning
Authors: Huh Dami , Kim Ji‐Hyun , Jo Il‐Hyun 
Published: August 2019

AbstractOne of the golden rules in instructional design methods is to optimize the use of working memory capacity and avoid cognitive overload. The study of cognitive load has historically relied on one's introspection. However, it is difficult to capture changes in cognitive load levels during learning sensitively. This paper suggests an approach to investigating dynamic changes in cognitive load by using a pupillometry. With the method, this study explores the effects of learners' prior knowledge and task complexity on cognitive load. An experiment was conducted on two groups of students (N = 19) with distinct levels of prior knowledge. In the experimental session, participants watched a video lecture on a mathematics proposition, while being eye‐tracked. The lecture consists of sections, which can be either a high task complexity or a low task complexity based on elements they have. Pupil dilations acquired in each section were used to explore the time course of cognitive load. To formulate cognitive load patterns, a time‐series clustering was used. The research conducted a chi‐square analysis to test differences in cognitive load patterns by prior knowledge and task complexity. Results show that pupil dilation patterns can be applied to monitor changes in cognitive load during learning.
Effects of BTK signalling in pathogenic microorganism infections
Authors: Ye Bingjue , Zhou Cheng , Guo Huiting , Zheng Min 
Published: August 2019

AbstractAs a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase (Btk) is widely considered as a vital kinase in many aspects of different physiologic processes. It is engaged in many important signalling pathways related to the immune response, such as the B cell receptor pathway, pattern‐recognition receptor pathway, and triggering receptor expressed on myeloid cell pathway. Recent studies have increasingly focused on the important role of Btk in various inflammatory diseases, which are related to Btk expression in myeloid innate immune cells, such as macrophages, dendritic cells and neutrophils. Although some investigations have explored the role of Btk in microbial infections, many aspects remain elusive, and some of the results are opposite and controversial. Considering the complicated and multiple roles of Btk in the immune system, we summarized the engagement of Btk signalling in various pathogenic microorganism infections, the possible mechanisms involved and its therapeutic potential in the control of infectious diseases.
Validation of the Serbian version of inflammatory Rasch‐built overall disability scale in patients with chronic inflammatory demyelinating polyradiculoneuropathy
Authors: Peric Stojan , Bozovic Ivo , Pruppers Marielle H. J. , Bjelica Bogdan , Stevic Zorica , Faber Catharina G. , Merkies Ingemar S. J. , Basta Ivana 
Published: August 2019

AbstractInflammatory Rasch‐built overall disability scale (I‐RODS) seems to be a valid activity measure for use in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Our aim was to translate and validate the I‐RODS for use in CIDP patients from Serbia. Study comprised 83 patients diagnosed with CIDP. I‐RODS was translated and cross‐culturally validated using the standard guidelines. Following scales were also administered: Medical Research Council (MRC) sum score, Inflammatory Neuropathy Cause and Treatment (INCAT) sensory and disability scores, Krupp's Fatigue Severity Scale, Beck Depression Inventory, Visual Analogue Scale for pain, and health survey‐36 (SF‐36) as a quality of life measure. According to the I‐RODS, significant proportion of our patients reported that “running” (51%), “dancing” (41%), and “standing for hours” (40%) were impossible tasks to perform, while “teeth brushing” (94%), “eating” (88%), and “reading a newspaper/book” (82%) were noted as the easiest items. Patients with more muscle weakness (lower MRC sum score) and more severe INCAT sensory score had lower I‐RODS score (P < .01). Also, patients with fatigue, depression and pain had lower I‐RODS scores (P < .01). I‐RODS score correlated with the INCAT disability score (P < 0.01) was 78 ± 19 compared to 51 ± 30 in patients with INCAT >1 (P < .01). I‐RODS score correlated with the total SF‐36 score (rho = +0.73, P < .01), as well as with all SF‐36 domain scores. Serbian version of the I‐RODS seems to be a valid activity measure for use in CIDP patients. I‐RODS was able to assess different levels of disability, it was in association with impairment measures, INCAT disability scale and quality of life. Further studies are needed to assess its responsiveness.
Where Is the Risk in Value? Evidence from a Market‐to‐Book Decomposition
Authors: GOLUBOV ANDREY , KONSTANTINIDI THEODOSIA 
Published: August 2019

ABSTRACTWe study the value premium using the multiples‐based market‐to‐book decomposition of Rhodes‐Kropf, Robinson, and Viswanathan (2005). The market‐to‐value component drives all of the value strategy return, while the value‐to‐book component exhibits no return predictability in either portfolio sorts or firm‐level regressions. Existing results linking market‐to‐book to operating leverage, duration, exposure to investment‐specific technology shocks, and analysts’ risk ratings derive from the unpriced value‐to‐book component. In contrast, results on expectation errors, limits to arbitrage, and certain types of cash flow risk and consumption risk exposure are due to the market‐to‐value component. Overall, our evidence casts doubt on several value premium theories.
Nonfinancial Firms as Cross‐Market Arbitrageurs
Authors: MA YUERAN 
Published: August 2019

ABSTRACTI demonstrate that nonfinancial corporations act as cross‐market arbitrageurs in their own securities. Firms use one type of security to replace another in response to shifts in relative valuations, inducing negatively correlated financing flows in different markets. Net equity repurchases and net debt issuance both increase when expected excess returns on debt are particularly low, or when expected excess returns on equity are relatively high. Credit valuations affect equity financing as much as equity valuations do, and vice versa. Cross‐market corporate arbitrage is most prevalent among large, unconstrained firms, and helps account for aggregate financing patterns.
Brokers and Order Flow Leakage: Evidence from Fire Sales
Authors: BARBON ANDREA , DI MAGGIO MARCO , FRANZONI FRANCESCO , LANDIER AUGUSTIN 
Published: August 2019

ABSTRACTUsing trade‐level data, we study whether brokers play a role in spreading order flow information in the stock market. We focus on large portfolio liquidations that result in temporary price drops, and identify the brokers who intermediate these trades. These brokers’ clients are more likely to predate on the liquidating funds than to provide liquidity. Predation leads to profits of about 25 basis points over 10 days and increases the liquidation costs of the distressed fund by 40%. This evidence suggests a role of information leakage in exacerbating fire sales.