bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Much H2O Is There in the Ocean? The Structure of Water in Sea Water
Authors: Brewer Peter G. , Peltzer Edward T. , Walz Peter M. 
Published: December 2018

AbstractWe report on laboratory and field Raman spectroscopy experiments on the structure of water in sea water and describe this as a function of temperature and pressure. The Raman spectrum of water/seawater is dominated by the water stretching mode band with a frequency shift in the range 2,800–3,800 cm−1. Here the hydrogen bonded (HB) clusters of several water molecules and nonhydrogen bonded (nHB, singlet H2O) forms are revealed with an isoskedastic point, similar to the isosbestic point for pH sensitive dyes. This band can be deconvolved into five Gaussian peaks, each with a specific spectroscopic assignment. We find that within the temperature range of 0–40 °C the vastly greater mass and volume of ocean water (78–85%) is in the HB forms, dominantly as (H2O)5. Without hydrogen bonding there would be no ocean, and nowhere in the bulk ocean does the simple H2O molecule exceed 20% of the total. The fraction of water molecules in the solvation shell around ions in seawater represents a third type of water, bound to an ion but not hydrogen bonded. Approximately 6% of the water molecules present at 35 salinity are in this form, and their concentration is not affected by temperature or pressure. The HB forms are a continuum of species in rapid exchange. The fraction of nHB is driven solely by temperature. We find no evidence that increased pressure changes the population of the free singlet nHB molecule; pressure drives the dominantly (H2O)5 population toward a lower volume, nested, molecular state.
The archaeological ensemble from Campoverde (Agro Pontino, central Italy): new constraints on the Last Interglacial sea level markers
Authors: Marra F. , Petronio C. , Ceruleo P. , Di Stefano G. , Florindo F. , Gatta M. , La Rosa M. , Rolfo M. F. , Salari L. 
Published: December 2018

AbstractWe present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of the modern fallow deer subspeciesDama dama dama, which in peninsular Italy is not present before MIS 5e, providing a post-quem terminus of 125 ka for the deposit hosting the fossil remains. The geomorphological reconstruction shows that Campoverde is located within the highest of three paleosurfaces progressively declining towards the present coast, at average elevations of 36, 26 and 15 m a.s.l. The two lowest paleosurfaces match the elevation of the previously recognized marine terraces in this area; we define a new, upper marine terrace corresponding to the 36 m paleosurface, which we name Campoverde complex. Based on the provided evidence of an age as young as MIS 5e for this terrace, we discuss the possibility that previous identification of a tectonically stable MIS 5e coastline ranging 10–8 m a.s.l. in this area should be revised, with significant implications on assessment of the amplitude of sea-level oscillations during the Last Interglacial in the Mediterranean Sea.
Comparative genome analysis of marine purple sulfur bacterium Marichromatium gracile YL28 reveals the diverse nitrogen cycle mechanisms and habitat-specific traits
Authors: Zhu Bitong , Zhang Xiaobo , Zhao Chungui , Chen Shicheng , Yang Suping 
Published: December 2018

AbstractMangrove ecosystems are characteristic of the high salinity, limited nutrients and S-richness. Marichromatium gracile YL28 (YL28) isolated from mangrove tolerates the high concentrations of nitrite and sulfur compounds and efficiently eliminates them. However, the molecular mechanisms of nitrite and sulfur compounds utilization and the habitat adaptation remain unclear in YL28. We sequenced YL28 genome and further performed the comparative genome analysis in 36 purple bacteria including purple sulfur bacteria (PSB) and purple non-sulfur bacteria (PNSB). YL28 has 6 nitrogen cycle pathways (up to 40 genes), and possibly removes nitrite by denitrification, complete assimilation nitrate reduction and fermentative nitrate reduction (DNRA). Comparative genome analysis showed that more nitrogen utilization genes were detected in PNSB than those in PSB. The partial denitrification pathway and complete assimilation nitrate reduction were reported in PSB and DNRA was reported in purple bacteria for the first time. The three sulfur metabolism genes such as oxidation of sulfide, reversed dissimilatory sulfite reduction and sox system allowed to eliminate toxic sulfur compounds in the mangrove ecosystem. Several unique stress response genes facilitate to the tolerance of the high salinity environment. The CRISPR systems and the transposon components in genomic islands (GIs) likely contribute to the genome plasticity in purple bacteria.
Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE
Authors: Ha Hyun Ji , Park Hyun Ho 
Published: December 2018

AbstractCell death-inducing DFF45-like effect (CIDE) domain-containing proteins, DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, play important roles in apoptotic DNA fragmentation and lipid homeostasis. The function of DFF40/45 in apoptotic DNA fragmentation is mediated by CIDE domain filament formation. Although our recent structural study of DREP4 CIDE revealed the first filament-like structure of the CIDE domain and its functional importance, the filament structure of DREP2 CIDE is unclear because this structure was not helical in the asymmetric unit. In this study, we present the crystal structure and mutagenesis analysis of the DREP2 CIDE mutant, which confirmed that DREP2 CIDE also forms a filament-like structure with features differing from those of DREP4 CIDE.
Two-frame apparent motion presented with an inter-stimulus interval reverses optokinetic responses in mice
Authors: Miura Kenichiro , Sugita Yuko , Furukawa Takahisa , Kawano Kenji 
Published: December 2018

AbstractTwo successive image frames presented with a blank inter-stimulus interval (ISI) induce reversals of perceived motion in humans. This illusory effect is a manifestation of the temporal properties of image filters embedded in the visual processing pathway. In the present study, ISI experiments were performed to identify the temporal characteristics of vision underlying optokinetic responses (OKRs) in mice. These responses are thought to be mediated by subcortical visual processing. OKRs of C57BL/6 J mice, induced by a 1/4-wavelength shift of a square-wave grating presented with and without an ISI were recorded. When a 1/4-wavelength shift was presented without, or with shorter ISIs (≤106.7 ms), OKRs were induced in the direction of the shift, with progressively decreasing amplitude as the ISI increased. However, when ISIs were 213.3 ms or longer, OKR direction reversed. Similar dependence on ISIs was also obtained using a sinusoidal grating. We subsequently quantitatively estimated temporal filters based on the ISI effects. We found that filters with biphasic impulse response functions could reproduce the ISI and temporal frequency dependence of the mouse OKR. Comparison with human psychophysics and behaviors suggests that mouse vision has more sluggish response dynamics to light signals than that of humans.
Am seidenen Faden …
Authors: Johansson Kajsa , Oswald Nadine-Marie 
Published: December 2018

ZusammenfassungWenn Führungskräfte merken, dass Mitarbeiter ausgelaugt sind, dann sollten sie handeln. Das ist gar nicht so einfach, wie es den Anschein hat. Lesen Sie,
welche Tipps die BGW bereit hält im vierten Teil der Serie „Gesundheit als Führungsaufgabe“.
Lumen-apposing stents versus plastic stents in the management of pancreatic pseudocysts: a large, comparative, international, multicenter study
Authors: Yang Juliana , Chen Yen-I , Friedland Shai , Holmes Ian , Paiji Christopher , Law Ryan , Hosmer Amy , Stevens Tyler , Matheus Franco , Pawa Rishi , Mathur Nihar , Sejpal Divyesh , Inamdar Sumant , Berzin Tyler M. , DiMaio Christopher J. , Gupta Sanchit , Yachimski Patrick S. , Anderloni Andrea , Repici Alessandro , James Theodore , Jamil Laith H. , Ona Mel , Lo Simon K. , Gaddam Srinivas , Dollhopf Markus , Alammar Nuha , Shieh Eugenie , Bukhari Majidah , Kumbhari Vivek , Singh Vikesh , Brewer Olaya , Sanaei Omid , Fayad Lea , Ngamruengphong Saowanee , Shin Eun Ji , Baron Todd H. , Khashab Mouen A. 
Published: December 2018

Abstract
Background Larger caliber lumen-apposing stents (LAMSs) have been increasingly used in the management of pancreatic fluid collections, specifically when solid debris is present; however, their advantages over smaller caliber plastic stents in the management of pancreatic pseudocysts are unclear. The aim of this study was to investigate the safety and efficacy of LAMS specifically in the management of pancreatic pseudocysts compared with double-pigtail plastic stents (DPPSs).
Methods We performed a multicenter, international, retrospective study between January 2012 and August 2016. A total of 205 patients with a diagnosis of pancreatic pseudocysts were included, 80 patients received LAMSs and 125 received DPPSs. Measured outcomes included clinical success, technical success, adverse events, stent dysfunction, pancreatic pseudocyst recurrence, and need for surgery.
Results Technical success was similar between the LAMS and the DPPS groups (97.5 % vs. 99.2 %; P = 0.32). Clinical success was higher for LAMSs than for DPPSs (96.3 % vs. 87.2 %; P = 0.03). While the need for surgery was similar between the two groups (1.3 % vs. 4.9 %, respectively; P = 0.17), the use of percutaneous drainage was significantly lower in the LAMS group (1.3 % vs. 8.8 %; P = 0.03). At 6-month follow-up, the recurrence rate was similar between the groups (6.7 % vs 18.8 %, respectively; P = 0.12). The rate of adverse events was significantly higher in the DPPS group (7.5 % vs. 17.6 %; P = 0.04). There was no difference in post-procedure mean length of hospital stay (6.3 days [standard deviation 27.9] vs. 3.7 days [5.7]; P = 0.31).
Conclusion When compared to DPPSs, LAMSs are a safe, feasible, and effective modality for the treatment of pancreatic pseudocysts and are associated with a higher rate of clinical success, shorter procedure time, less need for percutaneous interventions, and a lower overall rate of adverse events.
Welcher Belastungstest bei Verdacht auf stabile Angina
pectoris?
Authors: Dörr Rolf 
Published: December 2018

ZusammenfassungStress-Echo, Myokard-Perfusions-SPECT, Stress-Perfusions-MRT,
Dobutamin-Stress-MRT und CT-Angiografie sind dem Belastungs-EKG jeweils deutlich
überlegen. Das Belastungs-EKG kann eine stenosierende KHK bei höherer
KHK-Vortestwahrscheinlichkeit niemals mit Sicherheit ausschließen. Es wird
deshalb von der Nationalen VersorgungsLeitlinie Chronische KHK nur noch
eventuell als Methode zweiter Wahl für eine Vortestwahrscheinlichkeit zwischen
15 % und 30 % empfohlen.
Refractory Severe Thrombocytopenia during Pregnancy: How to Manage
Authors: Amorim Joana Gomes de , Abecasis Manuel Rocha , Rodrigues Filipa Maria Nogueira Lança 
Published: December 2018

AbstractThrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. At 28 weeks of gestation, she presented with petechiae, epistaxis, and gingival bleeding, with a platelet count of 3 × 109/L and positive IgG antiplatelet antibodies test. At a multidisciplinary discussion, it was decided to delay a cesarean section, due to the absence of fetal distress and to the high risk of morbidity for the patient. Many therapies were attempted without success. The IgG produced a slight and transient increase in the platelet count. On the 36th week of gestation, an elective cesarean section was performed. The perioperative period transfusions were guided by rotational thromboelastometry (ROTEM) monitoring. The procedure was performed under general anesthesia and videolaryngoscopy-assisted intubation. The patient was hemodynamically stable, without significant bleeding, and was transferred to the intensive care unit. The platelet count eventually decreased and a splenectomy was performed. Regional anesthesia may be contraindicated, and general anesthesia is associated with an increased risk of airway hemorrhage due to traumatic injury during the tracheal intubation and of hemorrhage associated with the surgical procedure. A multidisciplinary approach is essential in high-risk cases.
Early Intracranial Aneurysm Recurrence after Microsurgical Clip Ligation: Case Report and Review of the Literature
Authors: Marbacher Serge , Spiessberger Alexander , Diepers Michael , Remonda Luca , Fandino Javier 
Published: December 2018

AbstractMicrosurgical clip ligation is considered a definitive treatment for intracranial aneurysms (IAs), resulting in low rates of local recurrence that range from 0.2 to 0.5% and a latency period that averages about a decade. Our case report describes an early asymptomatic recurrence (i.e., without sentinel headache or seizure) less than 1 year after this 20-year-old woman underwent clip ligation of a ruptured anterior communicating artery (AComA) aneurysm. At recurrence, the patient underwent coiling of the regrowth; follow-up imaging at 6 and 18 months demonstrated complete IA occlusion. To review the putative risk factors of this rare phenomenon, the authors searched the PubMed database using the keywords “intracranial aneurysm,” “recurrence,” and “clipping” in various combinations. In the seven cases identified, all occurred in initially ruptured IA, which was often at the AComA, and six of seven patients were younger than 50 years old. Although most IA remnants grow slowly, early recurrence may represent a more aggressive biological behavior that warrants special attention in younger patients, positive rupture status, and unintended remnant of any size. In such a constellation, early imaging follow-up within the first 6 months may be warranted to rule out early IA recurrence
Effect of the heat treatment on the microstructure and mechanical properties of medium-Mn-steels
Authors: Schneider Reinhold , Steineder Katharina , Krizan Daniel , Sommitsch Christof 
Published: December 2018

The heat-treatment (HT) schedule and selected annealing parameters have a substantial effect on the microstructure and mechanical properties of medium-Mn-steels. The structure morphology depends on the fact, whether the austenite-reverted transformation takes place from deformed (one-step HT) or non-deformed (two-step HT) microstructures. Depending on the intercritical annealing temperature, the stability of the retained austenite can be altered to a large extent. As a result, the mechanical properties can be adjusted from high strength with excellent ductility to very high strength with reasonable ductility. The present contribution, therefore, elucidates the dependence of the microstructural characteristics and material behaviour on the HT parameters for medium-Mn alloy compositions with different Mn-contents. This paper is part of a Thematic Issue on Medium Manganese Steels.
Icon and taboo: single-payer politics in Canada and the US
Authors: Tuohy Carolyn Hughes 
Published: December 2018

AbstractIn 1965 and 1966, the United States and Canada adopted single-payer models of government insurance for physician and hospital services – universal in Canada, but restricted to certain population groups in the US. At the time, the American and Canadian political economies of health care and landscapes of public opinion were remarkably similar, and the different policy designs must be understood as products of the distinctive macro-level politics of the day. Subsequently, however, the different scopes of single-payer coverage would drive the two systems in different directions. In Canada, the single-payer system became entrenched in popular support and in the nexus of interest it created between the medical profession and the state. In the US, Medicare became similarly entrenched in popular support, but did so as part of the larger multi-payer private insurance system. In the process universal single-payer coverage became politically iconic in Canada and taboo in the US.
Self-reported Instances of Major Discrimination, Race/Ethnicity, and Inflammation Among Older Adults: Evidence From the Health and Retirement Study
Authors: Cobb Ryon J , Parker Lauren J , Thorpe Roland J 
Published: December 2018

Abstract

Background
This study examines the relationship between self-reported instances of major discrimination and inflammation among older adults, and explores whether this relationship varies in accordance with race/ethnicity. We hypothesized that self-reported instances of major discrimination would be associated with higher levels of high-risk inflammation and that this relationship would be stronger for racial/ethnic minorities than whites.

Methods
Data from the 2006/2008 Health and Retirement Study, an ongoing biennial nationally representative sample of older adults in the United States, were used to collect measures of self-reported instances of major discrimination and high-risk C-reactive protein (CRP), which was assayed from blood samples. Modified Poisson regression with robust standard errors was applied to estimate the prevalence ratios of self-reported instances of major discrimination, as it relates to high-risk CRP (CRP ≥ 22 kg/m2), and test whether this relationship varies by race/ethnicity.

Results
Respondents who experienced any instances of major discrimination had a higher likelihood of high-risk CRP (prevalence ratio [PR]: 1.14, 95% confidence interval [CI] = 1.07–1.22) than those who did not report experiencing any instances of major discrimination. This association was independent of differences in newly diagnosed health conditions and socioeconomic status. The relationship between any self-reported instance of major discrimination and high-risk CRP was weaker for blacks than whites (PR: 0.81, 95% CI = 0.69–0.95).

Conclusions
Our study confirms that self-reported instances of major lifetime discrimination is a psychosocial factor that is adversely associated with high-risk CRP among older adults; this association is especially pronounced among older whites. Future studies among this population are required to examine whether the relationship between self-reported instances of major discrimination and high-risk CRP changes over time.
Neuromuscular Mechanosensitivity in Subjects with Chronic Ankle Sprain: A Cross-Sectional Study
Authors: Lorenzo-Sánchez-Aguilera Cristina , Rodríguez-Sanz David , Gallego-Izquierdo Tomás , Lázaro-Navas Irene , Plaza-Rodríguez Josue , Navarro-Santana Marcos , Pecos-Martín Daniel 
Published: December 2018

Abstract

Background
Ankle sprain is one of the most common musculoskeletal injuries in sports, at work, and at home. Subjects who suffer from this injury may develop ankle instability. Functional instability has been associated with a high rate of resprain and impaired neuromuscular control in patients with ankle instability.

Objective
Measurement of neural and muscular mechanosensitivity after ankle sprain injury and establishment of the relationship between these variables.

Methods
A cross-sectional case-control study was performed with a sample of 58 students from Alcalá de Henares University (21 males and 37 females, mean age ± SD = 21 ± 3.7 years). Subjects were divided into two groups: a case group (N = 29, subjects with unstable ankle) and a control group (N = 29, healthy subjects). The pressure pain threshold (PPT) of the tibialis anterior, peroneus longus, and peroneus brevis muscles and mechanosensitivity of the common peroneus and tibial nerves were evaluated in all subjects through a manual mechanical algometer.

Results
Neuromuscular PPTs showed significant differences (P &lt; 0.05) between both groups, such that, compared with the control group, the case group exhibited significantly lower PPT levels. In the case group, a strong positive correlation was observed between neural and muscular homolateral mechanosensitivity in both lower limbs.

Conclusions
Participants with chronic ankle instability showed higher neuromuscular mechanosensitivity in muscles and nerves surrounding the ankle joint than healthy subjects. These findings indicate that low PPT values may be associated with symptoms that characterize this disease.
Using Simulation to Improve Care of the Critically Ill Mental Health Patient at the End of Life
Authors: Mariolis Tara , McKew Carol 
Published: December 2018

Abstract
This article summarizes a pilot simulation using standardized patients that was designed to develop skills necessary to care for the critically ill mental health patient nearing the end of life. Although the simulation was found to be a valuable teaching strategy, additional research, with a rigorous design, is recommended to further develop this teaching method. The authors suggest adopting a theoretical framework for debriefing that would elicit emotions, address the emotional needs of students, and assist them to develop coping strategies and skills necessary to care for patients at the end of life.
Detecting Early Markers of Ventilator-Associated Pneumonia by Analysis of Exhaled Gas
Authors: Kunze-Szikszay Nils , Walliser Karoline , Luther Jakob , Cambiaghi Barbara , Reupke Verena , Dullin Christian , Vautz Wolfgang , Bremmer Felix , Telgheder Ursula , Zscheppank Cornelia , Quintel Michael , Perl Thorsten 
Published: December 2018

Objectives:
The detection of microbial volatile organic compounds or host response markers in the exhaled gas could give an earlier diagnosis of ventilator-associated pneumonia. Gas chromatography-ion mobility spectrometry enables noninvasive, rapid, and sensitive analysis of exhaled gas. Using a rabbit model of ventilator-associated pneumonia we determined if gas chromatography-ion mobility spectrometry is able to detect 1) ventilator-associated pneumonia specific changes and 2) bacterial species-specific changes in the exhaled gas.

Design:
Experimental in vivo study.

Setting:
University research laboratory.

Subjects:
Female New Zealand White rabbits.

Interventions:
Animals were anesthetized and mechanically ventilated. To induce changes in the composition of exhaled gas we induced ventilator-associated pneumonia via endobronchial instillation of either Escherichia coli group (n = 11) or Pseudomonas aeruginosa group (n = 11) after 2 hours of mechanical ventilation. In a control group (n = 11) we instilled sterile lysogeny broth endobronchially.

Measurements and Main Results:
Gas chromatography-ion mobility spectrometry gas analysis, CT scans of the lungs, and blood samples were obtained at four measurement points during the 10 hours of mechanical ventilation. The volatile organic compound patterns in the exhaled gas were compared and correlated with ventilator-associated pneumonia severity. Sixty-seven peak areas showed changes in signal intensity in the serial gas analyses. The signal intensity changes in 10 peak regions differed between the groups. Five peak areas (P_648_36, indole, P_714_278, P_700_549, and P_727_557) showed statistically significant changes of signal intensity.

Conclusions:
This is the first in vivo study that shows the potential of gas chromatography-ion mobility spectrometry for early detection of ventilator-associated pneumonia specific volatile organic compounds and species differentiation by noninvasive analyses of exhaled gas.