bluuebunny/crossref_metadata_2025_split huggingface dataset:
IsopretGO—analysing and visualizing the functional consequences of differential splicing
Authors: Karlebach Guy , Hansen Peter , Köhler Kristin , Robinson Peter N 
Published: December 2024

Abstract
Gene Ontology overrepresentation analysis (GO-ORA) is a standard approach towards characterizing salient functional characteristics of sets of differentially expressed genes (DGE) in RNA sequencing (RNA-seq) experiments. GO-ORA compares the distribution of GO annotations of the DGE to that of all genes or all expressed genes. This approach has not been available to characterize differential alternative splicing (DAS). Here, we introduce a desktop application called isopretGO for visualizing the functional implications of DGE and DAS that leverages our previously published machine-learning predictions of GO annotations for individual isoforms. We show based on an analysis of 100 RNA-seq datasets that DAS and DGE frequently have starkly different functional profiles. We present an example that shows how isopretGO can be used to identify functional shifts in RNA-seq data that can be attributed to differential splicing.
High-affinity A/T-rich DNA binding with a dimeric bisbenzamidine
Authors: Bouzada David , Paul Ananya , Sánchez Mateo I , Domínguez-Asenjo Bárbara , Lence Emilio , Melle-Franco Manuel , Ardá Ana , Barreiro-Piñeiro Natalia , Penas Cristina , Gómez-González Jacobo , Jiménez-Barbero Jesús , Moreno Javier , González-Bello Concepción , Wilson W David , Mascareñas José L , Vázquez M Eugenio 
Published: December 2024

Abstract
A bisbenzamidine DNA binding agent can be easily dimerized by alkylation of its terminal amidine groups to afford an extended minor groove binder with over 20-fold enhanced DNA affinity towards extended A/T-rich sites. NMR experiments in combination with molecular dynamics simulation studies provide structural insight into the insertion of this compound in the DNA minor groove, and antimicrobial assays demonstrate that the increased affinity translates into higher antileishmanial activity.
Chemical transformation of polyurethane into valuable polymers
Authors: Sun Bo , Zou Jiawei , Qiu Weijie , Tian Shuheng , Wang Maolin , Tang Haoyi , Wang Baotieliang , Luan Shifang , Tang Xiaoyan , Wang Meng , Ma Ding 
Published: December 2024

ABSTRACT
Polyurethanes are an important class of synthetic polymers, widely used in a variety of applications ranging from everyday items to advanced tools in societal infrastructure. Their inherent cross-linked structure imparts exceptional durability and flexibility, yet this also complicates their degradation and recycling. Here we report a heterogeneous catalytic process that combines methanolysis and hydrogenation with a CO2/H2 reaction medium, effectively breaking down PU waste consisting of urethane and ester bonds into valuable intermediates like aromatic diamines and lactones. These intermediates are then converted into functional polymers: polyimide (PI), noted for its exceptional thermal and electrical insulation, and polylactone (P(BL-co-CL)), a biodegradable alternative to traditional plastics. Both polymers exhibit enhanced performance compared to existing commercial products. This approach not only contributes to the valorization of plastic waste but also opens new avenues for the creation of high-performance materials.
Dramatic switchable polarities in conduction type and self-driven photocurrent of BiI3 via pressure engineering
Authors: Yue Lei , Tian Fuyu , Liu Ran , Li Zonglun , Li Ruixin , Li Chenyi , Li Yanchun , Yang Dongliang , Li Xiaodong , Li Quanjun , Zhang Lijun , Liu Bingbing 
Published: December 2024

ABSTRACT
The intentional manipulation of carrier characteristics serves as a fundamental principle underlying various energy-related and optoelectronic semiconductor technologies. However, achieving switchable and reversible control of the polarity within a single material to design optimized devices remains a significant challenge. Herein, we successfully achieved dramatic reversible p–n switching during the semiconductor‒semiconductor phase transition in BiI3 via pressure, accompanied by a substantial improvement in their photoelectric properties. Carrier polarity flipping was monitored by measuring the photocurrent dominated by the photothermoelectric (PTE) effect in a zero-bias two-terminal device. Accompanying the p–n transition, a switch between positive and negative photocurrents was observed in BiI3, providing a feasible method to determine the conduction type of materials via photoelectric measurements. Furthermore, the combined effects of the photoconductivity and PTE mechanism improved the photoresponse and extended the detection bandwidth to encompass the optical communication waveband (1650 nm) under an external bias. The remarkable photoelectric properties were attributed to the enhanced energy band dispersion and increased charge density of BiI3 under pressure. These findings highlight the effective and flexible modulation of carrier properties through pressure engineering and provide a foundation for designing and implementing multifunctional logic circuits and optoelectronic devices.
Local charge homogenization strategy enables ultra-high voltage tolerance of polyether electrolytes for 4.7 V lithium metal batteries
Authors: Wu Yuanlong , Luo Piao , Su Kexin , Yu Mao , Song Xin , Huang Lianzhan , Zhang Shaocong , Song Huiyu , Du Li , Liu Weishu , Cui Zhiming 
Published: December 2024

ABSTRACT
In-situ fabricated polyether electrolytes have been regarded as one of the most promising solid electrolyte systems. Nevertheless, they cannot match high-voltage cathodes over 4.3 V due to their poor oxidative stability. Herein, we propose an effective local charge homogenization strategy based on the triglycidyl isocyanurate (TGIC) crosslinker, achieving ultra-high-voltage electrochemical stability of polyether electrolytes (viz. PTIDOL) at cutoff voltages up to 4.7 V. The introduction of TGIC optimizes the Li+ solvation environment, thereby homogenizing the charge distribution at ether oxygen (EO) sites, resulting in significantly enhanced oxidative stability of the polyether main chain. Consequently, the Li|PTIDOL|LiNi0.6Co0.2Mn0.2O2 (NCM622) cell achieves long-term operation at an ultra-high cutoff voltage with a capacity retention of 81.8% after 400 cycles, one of the best results reported for polyether electrolytes to date. This work provides significant insights for the development of polyether electrolytes with high-voltage tolerance and the advancement of high-energy-density batteries.
Determination of the Hamiltonian from the Equations of Motion with Illustration from Examples
Authors: Lee Chung-Ru 
Published: December 2024

Abstract
In this paper, we study the determination of a Hamiltonian from given equations of motion. It can be cast into a problem of matrix factorization after reinterpretation of the system as first-order evolutionary equations in the phase space coordinates. We state the criterion on the evolution matrix for a Hamiltonian to exist. In addition, the proof is constructive and an explicit Hamiltonian with accompanied symplectic structure can be obtained. As an application, we will study a few classes of dynamical systems for illustration.
Perception of recurrence risk in patients with IgG4-related disease: a descriptive phenomenological study
Authors: Yu Kai , Gao Hui , Liu Shibo , Yao Haihong , Wang Xiaoqing , Luo Chenghua , Guo Qian , Shi Yuexian 
Published: December 2024

Abstract

Objective
About 40% of IgG4-related disease (IgG4-RD) patients face recurrence, severely impacting their quality of life. We aimed to explore the characteristics of the perception of recurrence risk in patients with IgG4-RD.

Methods
A qualitative study design with a descriptive phenomenological approach was used. Fourteen patients with IgG4-RD were recruited via purposive sampling, including six patients with first onset and eight patients experiencing recurrence. Semi-structured interviews were conducted to collect data, and transcripts were analysed by two independent researchers using Colaizzi’s descriptive analysis framework. The COREQ checklist was followed.

Results
Data analysis identified nine subthemes falling into four themes: (a) perception of differential susceptibility to recurrence; (b) perception of crucial recurrence risk factors; (c) perception of recurrence warning signs and medical behaviours; (d) perception of multiple recurrence outcomes. We found that susceptibility perception formed the basis of recurrence risk perception. For patients with first onset, the main manifestations were misconception or evasion of the risk of recurrence, whereas patients experienced recurrence demonstrated a clear perception of recurrence risk and feelings of fear. Based on this, other themes emerged.

Conclusions
Since the absence of accurate knowledge related to recurrence, the perception of recurrence risk in patients with IgG4-RD primarily manifested as misconception, evasion or feeling fear. Ultimately, they couldn’t take appropriate actions to prevent recurrence. Healthcare professionals should develop comprehensive interventions for patients with IgG4-RD, integrating health education, disease consultation and psychological support, with the aim of enhancing awareness of recurrence risk and empowering them to manage their conditions in the long term.
Prevailing predatory publishing: a critical evaluation of publications from Pakistan’s physical education and sport science domains
Authors: Azam Muhammad , Perveen Nargis 
Published: December 2024

Abstract
This study critically examined the increasing threat of predatory publications in academia, revealing how researchers at Pakistan’s Higher Education Institutions (HEIs) take advantage of this trend for academic gains. We examined the widespread trend of predatory publishing for Pakistani public and private HEIs, explicitly focusing on Physical Education and Sports Sciences (PESS). We carefully analysed a collection of (345) international articles from 48 faculty members of 26 HEIs (21 Public + 5 Private) until March 2024 extending by July 2024. We excluded 95 articles unrecognized by Pakistan’s Higher Education Commission (HEC) plus 11 undecided publications. Our results revealed that 214 (89.53%) of 239 so-called recognized international papers were published in hijacked/predatory journals. The authenticity of publications was determined by checking the HEC, Elsevier’s Scopus, and Web of Science (WOS) databases, respectively. Leading predatory publications, the University of Punjab from the public sector has 108 contributions from 5 PESS faculty members with no recognized articles. The University of Lahore, from the private sector, has 104 predatory contributions by 4 PESS faculty members with only two recognized articles. Among all Pakistani universities, PESS researchers from Government College University Lahore won the lead for (15 of 28) recognized research paper contributions with no predatory publication. Predatory publishing affects the credibility of the researchers engaged, posing a threat to the nation’s scientific reputation in the PESS arena. We suggest immediate policy initiatives to address this unethical practice and stress the need to maintain research integrity.
Blood pressure changes during methotrexate treatment: results from a randomized placebo-controlled trial among patients with cardiovascular risk
Authors: Cui Jing , Ridker Paul M , Solomon Daniel H 
Published: December 2024

Abstract

Objective
Low-dose MTX (LD-MTX) has been associated with a reduced risk of cardiovascular disease (CVD) among patients with systemic rheumatic diseases but not among the general population. Prior reports suggest that LD-MTX may reduce blood pressure (BP). We studied the effect of LD-MTX on BP.

Method
We examined data that compared LD-MTX to placebo in a randomized double-blind controlled clinical trial conducted among patients who had known CVD but without rheumatic disease. Systolic and diastolic BP (SBP, DBP) were collected as vital sign measurements at each scheduled study visit during 5 years of follow-up. Longitudinal SBP and DBP were compared between patients of LD-MTX and placebo arms using a linear mixed model.

Result
Data were used from 2391 patients randomized to LD-MTX and 2395 to placebo, with a mean follow-up of 26 months. At baseline, SBP and DBP were normally distributed with similar medians [SBP: 128 mmHg (IQR 118–139), DBP: 74 mmHg (IQR 67–80)] between patients from both treatment groups; 93% patients reported at baseline using at least one type of medication for hypertension. After treatment, compared with placebo, the estimated differences in changes of SBP and DBP in the LD-MTX group were &lt;1 mm (SBP: β = –0.75 mmHg, 95% CI –0.02 to –1.49; DBP: β = –0.56 mmHg, 95% CI –0.12 to –1.01).

Conclusion
Patients randomized to LD-MTX without systemic rheumatic disease had no clinically meaningful difference in BP compared with placebo.

Trial registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT 01594333.
Neutron dose estimation by 24Na measurements in the triage of exposed individuals after criticality accidents: a case study of the Tokaimura criticality accident
Authors: Kowatari Munehiko , Kurihara Osamu 
Published: December 2024

Abstract
We investigated the neutron dose estimation for the triage of personnel involved in criticality accidents by conducting 24Na measurements via the whole-body measurement method. For a case study, we examined the September 1999 Japan Nuclear Fuel Conversion Co. criticality accident (internationally known as “the Tokaimura accident”). We investigated the neutron-induced radionuclides produced in worker C’s body due to the irradiation of the primary pulse. A total of 87 radionuclides were identified, with activities ranging from 1.3 × 10−19 Bq to 6.9 × 106 Bq for worker C by Monte Carlo simulations. The radionuclide with the highest activity was revealed by calculation results: 28Al (t1/2 = 2.2 min) 6.9 × 106 Bq. The specific activity of 38Cl reached a level that was three times that of 24Na. These radionuclides would severely affect the 24Na measurement in the whole-body measurements performed in the immediate post-accident period. Spectrometry would be preferable for determining 24Na specific activities by whole-body measurements at accident sites.
Coordinated social interactions are supported by integrated neural representations
Authors: Formica Silvia , Brass Marcel 
Published: December 2024

Abstract
Joint actions are defined as coordinated interactions of two or more agents toward a shared goal, often requiring different and complementary individual contributions. However, how humans can successfully act together without the interfering effects of observing incongruent movements is still largely unknown. It has been proposed that interpersonal predictive processes are at play to allow the formation of a Dyadic Motor Plan, encompassing both agents’ shares. Yet, direct empirical support for such an integrated motor plan is still limited. In this study, we aimed at testing the properties of these anticipated representations. We collected electroencephalography data while human participants (N = 36; 27 females) drew shapes simultaneously to a virtual partner, in two social contexts: either they had to synchronize and act jointly or they performed the movements alongside, but independently. We adopted a multivariate approach to show that the social context influenced how the upcoming action of the partner is anticipated during the interval preceding the movement. We found evidence that acting jointly induces an encoding of the partner’s action that is strongly intertwined with the participant’s action, supporting the hypothesis of an integrative motor plan in joint but not in parallel actions.
Extracorporeal shock wave therapy as a treatment option for persistent clitoral priapism: a case report
Authors: Buford Karis , Phung Lauren , Zwaans Bernadette M M , Padmanabhan Priya , Rubin Rachel S , Peters Kenneth M 
Published: December 2024

Abstract

Introduction
Clitoral priapism is persistent clitoral engorgement without sexual stimulation. Presentation is sparse, and therefore limited treatment options have been investigated.

Aim
We present a case report of a 34-year-old female presenting with persistent nonischemic clitoral priapism 5 years after aggressive clitoral stimulation.

Methods
Patient underwent six weekly Li-ESWT sessions at frequency 4 Hz, energy 0.11 mJ for 2000 shocks per session. Assessment included physical examination of clitoral glans engorgement and retraction, global response assessment (GRA) score, need for topical phenylephrine, and ability to achieve orgasm.

Results
At the end of the therapy, examination revealed complete resolution of priapism with a normal-appearing clitoris fully retracted behind the clitoral hood. The patient reported no longer requiring topical phenylephrine, a significant improvement in GRA, and the ability to achieve orgasm.

Conclusion
We present a case of nonischemic clitoral priapism resolved with Li-ESWT. More investigation regarding the utilization of Li-ESWT in the treatment of clitoral priapism is highly encouraged.
O047 Associations between adolescent sleep, mental health and mental health inequities in Aotearoa New Zealand: Findings from the Youth19 Survey
Authors: Muller D , Paine S , Shanthakumar M , Clark T , Crengle S , Donkin L , Signal L 
Published: December 2024

Abstract

Introduction
Sleep and mental health are closely linked. In Aotearoa New Zealand, poor mental health is more prevalent for Māori and Pacific adolescents, who are disproportionately impacted by social and sleep inequities, raising the question of whether sleep contributes to adolescent mental health inequities. We aimed to (1) examine associations between sleep and mental health and (2) explore the contribution of sleep to associations between ethnicity and mental health, by conducting secondary analyses of cross-sectional Youth19 Survey data.

Methods
Multivariable logistic regression models were concurrently and sequentially adjusted for social determinants of health (e.g., housing deprivation), covariates (e.g., school year) and sleep (sleep duration; bedtime; waketime) to investigate independent associations between sleep and mental health (anxiety symptoms; depressive symptoms; attempted suicide) and the contribution of sleep to mental health inequities respectively.

Results
The sample comprised 7,721 12-18 year-olds. Independent associations (OR [95% CI]) were found between short sleep and anxiety (1.24 [1.06-1.46]) and depressive (1.75 [1.31-2.32]) symptoms; bedtime after midnight and attempted suicide (1.93 [1.13-3.30]); and waketime before 6am and attempted suicide (1.71 [1.12-2.62]). Māori and Pacific adolescents had increased odds of all mental health measures. Adjusting for social determinants and covariates fully attenuated these relationships for anxiety and depressive symptoms and partially for attempted suicide. Further adjustment for sleep reduced point estimates, although the inequity in attempted suicide remained for Pacific adolescents.

Discussion
Sleep may be a pathway linking social disadvantage to poor adolescent mental health. Sleep and social inequities must be addressed to support equitable adolescent mental health.
P046 Towards defining the sleep phenotype of children with neurofibromatosis type 1
Authors: Pride N , Banks S , Arnold S , Haebich K , North K , Rossi A , Yates C , Payne J 
Published: December 2024

Abstract

Introduction
Research involving drosophila highlight the role of the NF1 gene in regulating the sleep-wake cycle. Despite this, there remains limited knowledge about sleep in people who carry a mutation in the NF1 gene, also known as Neurofibromatosis type 1 (NF1).

Methods
The study aimed to characterise sleep disturbance and its impact in children with NF1. The sleep patterns of children with NF1 (n=93) and TD children (n=45) were compared using actigraphy, sleep diary, the Sleep Disturbance Scale (SDSC), Paediatric Sleep Questionnaire (PSQ) and neuropsychological assessment.

Results
SDSC indicated 59% of parents of children with NF1 and 32% of parents of controls reported sleep disturbances. The PSQ-derived PLMD and SDB scales identified suspected cases, with 5-6% of TD children and 38% and 30% of children with NF1 meeting the clinical thresholds for SDB and PLMD, respectively. Actigraphy showed children with NF1 had significantly longer sleep onset latency (p=.001), lower sleep efficiency (p=.002), and less total sleep time (p&lt;.05). Correlation analysis in children with NF1 revealed significant links between SDB scores and sleep efficiency, reading, executive functions, depression, adaptive functioning, fatigue, and QoL (p&lt;.01). PLMD scores were significantly correlated with pain, executive functioning, and QoL.

Conclusion
This study is the first to document abnormal sleep patterns in children with NF1 using actigraphy. Results highlight the significant sleep problems these children face and the need for clinicians to routinely screen for the presence of sleep disorders such as SDB or PLMD. Early intervention to improve sleep may improve sleep problems and functioning.
O072a The relationship between bedtime procrastination, habitual smartphone use, and sleep in young adults: Results from the Young Adult Health Study (YAHS)
Authors: Bild E , Rossa K , Edmed S , Pattinson C , Mann D , Gadam S , Srinivasan A , Sullivan K , Salmon P , Smith S 
Published: December 2024

Abstract

Introduction
A potential explanation for the relationship between screen-based digital technology use and poor sleep health is bedtime procrastination (alongside arousing content and circadian disruption from light emitting devices). This study aimed to provide insight into the mechanisms linking digital technology and sleep in young adults by exploring associations between bedtime procrastination (where individuals delay bedtime for no external reason), habitual smartphone use, and sleep duration.

Methods
Data from this study were drawn from baseline assessments of a larger randomised control trial examining an intervention to extend sleep in young adults. To enter the trial participants (N=99, aged 18-24; 70.7% female) reported typically sleeping &lt;7hrs per night, and &lt;6hrs on at least 2 nights per week. Participants wore an actigraph for two weeks to assess habitual sleep timing and duration. Average weekly habitual smartphone use was collected from a smartphone application. Standardised measures to assess other constructs (including bedtime procrastination) were also completed.

Results
Later average actigraphy derived bedtimes and waketimes were significantly associated with bedtime procrastination (r=.38, p&lt;.001, and r=.28, p&lt;.001, respectively), however, greater bedtime procrastination was not associated with average smartphone use (r=.13), sleep duration (r=-.13), or sleep disturbance (r=.16). Increased bedtime procrastination was associated with increased daytime sleep-related impairment (r=.45, p&lt;.001), anxiety (r=.23, p&lt;.05), and depression (r=.22, p&lt;.05).

Discussion
Our findings do not support the ‘displacement’ hypothesis that screen use influences sleep health by displacing time usually spent sleeping. This result is inconsistent with past research showing a temporal relationship between bedtime procrastination and increased smartphone use.