bluuebunny/crossref_metadata_2025_split huggingface dataset:
The temporal pattern of creativity and implementation in teams
Authors: Rosing Kathrin , Bledow Ronald , Frese Michael , Baytalskaya Nataliya , Johnson Lascano Johanna , Farr James L. 
Published: June 2018

Two broad sets of activities underlie team innovation: the creation and the implementation of new ideas. Despite the prevalence of this distinction, the temporal dynamics of creativity and implementation in teams and their relation to successful team innovation are not well understood. Building on and integrating linear phase models and complexity perspectives on the innovation process, we propose a temporal pattern of creativity and implementation that is linked to team innovation. We examine this temporal pattern in a longitudinal study of 76 project teams. Results show that teams engage in creativity throughout the entire life cycle of team projects; however, innovative teams refrain from focusing on implementation in early time frames and increase their focus on implementation over the course of the project. Episodes of unconstrained creativity in early time frames of a project appear to be a critical factor for team innovation. Our research provides a foundation for future research on team innovation that explicitly considers the temporal interplay of creativity and implementation.Practitioner points

Creativity is a critical factor for team innovation that is relevant not only in the beginning of a team project but throughout its entire life cycle.

Teams achieve innovative outcomes if they refrain from focusing on implementation early on and instead allow for prolonged episodes of unconstrained creativity.

Innovative teams pay attention to the timing of implementation activities and increase their focus on implementation around the mid‐point of a project.
Parental Conformity Expectations' Effect on Twins' and Singletons' Parent–Adolescent Relationships: Associations With Change in Adjustment From Middle Childhood to Adolescence
Authors: Anderson Kayla N. , Rueter Martha A. , Connor Jennifer J. , Koerner Ascan F. 
Published: June 2018

Growing use of in vitro fertilization (IVF) has resulted in an elevated twin birth rate, and a burgeoning population of IVF twins who are now aging into adolescence and beyond. This study tests a model examining whether parental conformity expectations have differential effects on twins' versus singletons' parent–adolescent relationship satisfaction, and if this effect is indirectly associated with relative changes in twins' and singletons' internalizing and externalizing behavior from middle childhood to adolescence. Using a sample of 278 IVF twins and singletons, path models demonstrate that twin status and conformity expectations interact to influence parent–adolescent relationships. Although there was an association between twin status and mother–adolescent relationship satisfaction among parents with high conformity expectations (r = .25, p < .01), this relationship was nonsignificant among parents with low conformity expectations (r = .05, p = .85). The differential effect of conformity expectations on parent–adolescent relationship satisfaction for twins and singletons was indirectly associated with relative changes in twins' and singletons' externalizing behavior from middle childhood to adolescence. Results demonstrate that higher levels of parental conformity expectations may not have the same effect on adolescent twins and singletons.
Coming Closer in Adolescence: Convergence in Mother, Father, and Adolescent Reports of Parenting
Authors: Mastrotheodoros Stefanos , Van der Graaff Jolien , Deković Maja , Meeus Wim H. J. , Branje Susan J. T. 
Published: June 2018

Parent–child relationships change during adolescence. Furthermore, parents and adolescents perceive parenting differently. We examined the changes in perceptions of parental practices in fathers, mothers, and adolescents during adolescence. Furthermore, we investigated if fathers', mothers', and adolescents' perceptions converge during adolescence. Following 497 families across six waves (ages 13–18), we investigated the development of parental support and behavioral control using mother and father self‐reports, and adolescent reports for mothers and fathers. We found curvilinear decrease for support and control. Parent–adolescent convergence emerged over the 6 years: those with higher intercepts had a steeper decrease, whereas correlations among parent and adolescent reports increased. This multi‐informant study sheds light on the development of parent–adolescent convergence on perceptions of parenting.
Population variability in animal health: Influence on dose–exposure–response relationships: Part I: Drug metabolism and transporter systems
Authors: Martinez Marilyn N. , Court Michael H. , Fink‐Gremmels Johanna , Mealey Katrina L. 
Published: June 2018

AbstractThere is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose–exposure–response relationships and can affect the drug residues present in the edible tissues of food‐producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product recipients, both endogenous and exogenous variables need to be considered. The American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session during the 2017 Biennial meeting to explore the sources of population variability recognized to impact veterinary medicine. The following review highlights the information shared during that session. In Part I of this workshop report, we consider sources of population variability associated with drug metabolism and membrane transport. PartIIof this report highlights the use of modeling and simulation to support an appreciation of the variability in dose–exposure–response relationships.
Positive selection on sociobiological traits in invasive fire ants
Authors: Privman Eyal , Cohen Pnina , Cohanim Amir B. , Riba‐Grognuz Oksana , Shoemaker DeWayne , Keller Laurent 
Published: June 2018

AbstractThe fire ant Solenopsis invicta and its close relatives are highly invasive. Enhanced social cooperation may facilitate invasiveness in these and other invasive ant species. We investigated whether invasiveness in Solenopsis fire ants was accompanied by positive selection on sociobiological traits by applying a phylogenomics approach to infer ancient selection, and a population genomics approach to infer recent and ongoing selection in both native and introduced S. invicta populations. A combination of whole‐genome sequencing of 40 haploid males and reduced‐representation genomic sequencing of 112 diploid workers identified 1,758,116 and 169,682 polymorphic markers, respectively. The resulting high‐resolution maps of genomic polymorphism provide high inference power to test for positive selection. Our analyses provide evidence of positive selection on putative ion channel genes, which are implicated in neurological functions, and on vitellogenin, which is a key regulator of development and caste determination. Furthermore, molecular functions implicated in pheromonal signalling have experienced recent positive selection. Genes with signatures of positive selection were significantly more often those overexpressed in workers compared with queens and males, suggesting that worker traits are under stronger selection than queen and male traits. These results provide insights into selection pressures and ongoing adaptation in an invasive social insect and support the hypothesis that sociobiological traits are under more positive selection than nonsocial traits in such invasive species.
A Methodology to Account for One‐Way Infrastructure Interdependency in Preservation Activity Scheduling
Authors: Alinizzi Majed , Chen Sikai , Labi Samuel , Kandil Amr 
Published: June 2018

AbstractThis article develops an optimization framework for scheduling a programmable preservation activity for an infrastructure (primary) system that accounts for a specific context of interdependency between its maintenance phase and the operations phase of a neighboring (secondary) system. The framework identifies the optimal deterioration threshold of the primary system for the preservation activity, subject to a disruption in the operations of the neighboring system. The methodology also includes trade‐off analysis using a biobjective genetic algorithm approach to accommodate the conflicting objectives associated with the costs and benefits of the programmed preservation activity. The framework provides decision makers with optimal/near optimal Pareto frontiers of the primary system's preservation activity candidate thresholds based on the costs and benefits associated with each candidate. The article demonstrates the developed framework using a case study involving colocated pavement and underground utility systems. The results of the case study show that it is feasible to use the developed framework to identify the optimal preservation activity timing for an infrastructure system whose level of service is subject to disruptions from a neighboring system. Overall, the results demonstrate that a disruptive event caused by a secondary system could influence the Pareto optimal solutions (activity thresholds) associated with the timing of a primary system's preservation activity. The article validates the optimal solution by comparing the results with those obtained using the exact method.
Breast cancer screening behaviors among Chinese women in Mainland China
Authors: Bao Yingyi , Kwok Cannas , Lee Chun Fan 
Published: June 2018

AbstractIn the present study, we reported on the current breast cancer screening rates among Chinese women in China and examined whether demographic factors and cultural beliefs were associated with their screening behavior. A cross‐sectional survey was conducted with a convenience sample of 494 Chinese women who completed the modified Breast Cancer Screening Beliefs Questionnaire (BCSBQ). Two‐sample t‐tests and multivariable logistic regression were employed to analyze the data. The results indicated that participation in screening practices ranged from 27.5% for breast self‐examination (BSE), 36.4% for clinical breast examination, 23.5% for mammography, and 40% for ultrasonography. Women who had previously engaged in one of the four screening practices had significantly higher scores on the three subscales of the modified BCSBQ. Being older and having a friend who had been diagnosed with breast cancer were shown to be predictors for BSE and participation in either mammography or ultrasonography, respectively. Education levels were also shown to be positively associated with the four screening measures. We suggest that cultural beliefs about breast cancer and screening practices play a significant role in Chinese women's screening behavior.
Decisional conflict in end‐of‐life cancer treatment among family surrogates: A cross‐sectional survey
Authors: Jeon Bo Min , Kim Su Hyun , Lee Soo Jung 
Published: June 2018

AbstractThe aims of this study were to examine the extent of decisional conflict in end‐of‐life cancer treatments and to investigate the influences and predictors of decisional conflict among family surrogates. A cross‐sectional, descriptive, correlational design was applied. Data were collected from a convenience sample of 102 family members who had participated in end‐of‐life cancer decision‐making. We enrolled participants from inpatient oncology units at a university hospital in South Korea from May 2014 to January 2016. The results indicated that many family surrogates had high levels of decisional conflict and psychological stress after end‐of‐life cancer decision‐making. Hierarchical multiple regression analyses demonstrated that decisional conflict had significant, substantial influences on decision regret and psychological stress after controlling for demographic variables. Family surrogates who were aware of the patients' wishes about end‐of‐life treatments and those who had good family functioning had less decisional conflict. To relieve decisional conflict regarding end‐of‐life cancer treatment among family surrogates, it is necessary to encourage patients to share their end‐of‐life treatment wishes with family members and to consider family functioning in the end‐of‐life decision‐making process.
Molecular landscape of esophageal cancer: implications for early detection and personalized therapy
Authors: Talukdar Fazlur Rahman , di Pietro Massimiliano , Secrier Maria , Moehler Markus , Goepfert Katrin , Lima Sheila Soares Coelho , Pinto Luis Felipe Ribeiro , Hendricks Denver , Parker Mohamed Iqbal , Herceg Zdenko 
Published: June 2018

AbstractEsophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical distribution, possibly due to differences in exposure to risk factors and lifestyles. ESCC and EAC are distinct diseases in terms of cell of origin, epidemiology, and molecular architecture of tumor cells. Past efforts aimed at translating potential molecular candidates into clinical practice proved to be challenging, underscoring the need for identifying novel candidates for early diagnosis and therapy of EC. Several major international efforts have brought about important advances in identifying molecular landscapes of ESCC and EAC toward understanding molecular mechanisms and critical molecular events driving the progression and pathological features of the disease. In our review, we summarize recent advances in the areas of genomics and epigenomics of ESCC and EAC, their mutational signatures and immunotherapy. We also discuss implications of recent advances in characterizing the genome and epigenome of EC for the discovery of diagnostic/prognostic biomarkers and development of new targets for personalized treatment and prevention.
Effects of intramuscular morphine in men and women with temporomandibular disorder with myofascial pain
Authors: Kang Soo‐Kyung , Lee Yeon‐Hee , Park Hyeji , Ro Jin Y. , Auh Q‐Schick 
Published: June 2018

AbstractObjectivesThis placebo‐controlled randomized double‐blinded clinical study assessed the analgesic efficacy of intramuscular morphine inTMDpatients with myofascial pain and sex‐dependent responses of the morphine treatment.Subjects and MethodsMen and women withTMDwere treated with morphine (1.5 or 5 mg), lidocaine, or saline in the masseter muscle.VASof pain intensity,PPT, andPPtol were compared between treatment groups and gender. An additional group was treated with morphine in the trapezius muscle to evaluate the systemic effect of morphine that may reduce pain in the masseter muscle.ResultsThere was a significant difference inVASscores between the morphine 5 mg group and the saline group favoring morphine, but not between the morphine 5 mg and lidocaine. Morphine 1.5 and 5 mg treatments led to consistently and significantly elevatedPPTandPPtol measures in men, but not in women. Morphine administered in the trapezius muscle did not affect the outcome measures.ConclusionA single dose intramuscular morphine produced analgesic effects up to 48 hr in patients with myofascial pain. Intramuscular morphine elevated mechanical pain threshold and tolerance in the masseter only in male patients, suggesting sex differences in local morphine effects. No systemic effect of intramuscular morphine was detected.
Afterdepolarizations and triggered activity as a mechanism for clinical arrhythmias
Authors: Wit Andrew L. 
Published: June 2018

AbstractAfterdepolarizations cause triggered arrhythmias. One kind occurs after repolarization is complete, delayed afterdepolarizations (DADs). Another occurs as an interruption in repolarization, early afterdepolarizations (EADs). Afterdepolarizations initiate arrhythmias when they depolarize membrane potential to threshold potential for triggering action potentials.DADs usually occur mostly when Ca2+ in the sarcoplasmic reticulum (SR) is elevated. The SR leaks some of the Ca2+ into the myoplasm through Ca2+ release channels controlled by ryanodine receptors (RyR2) during diastole. The Na+‐Ca2+ exchanger extrudes elevated diastolic Ca2+ from the cell in exchange for Na+ (1 Ca2+ for 3 Na+) generating inward current causing DADs.DAD amplitude increases with decreasing cycle length, causing triggered activity during an increase in heart rate or during programmed electrical stimulation (PES). Coupling interval of the first triggered impulse is directly related to initiating cycle length.EADs are associated with an increased action potential duration (APD) causing long QT (LQT). EADs are caused by net inward currents (ICaL, INCX) as a consequence. Hundreds of mutations can cause congenital LQT by altering repolarizing ion channels. Acquired LQT results from drug interaction with repolarizing ion channels. EAD‐triggered ventricular tachycardia is polymorphic and called “torsade de pointes.” Effects of PES on EAD‐triggered activity is related to effects of cycle length on APD. Shortening cycle length prevents EADs by accelerating repolarization. Typical PES protocols inhibit formation of EADs which can be therapeutic.
Eosinophilic inflammation in lymph nodes of dogs with visceral leishmaniasis
Authors: Costa Sidnei Ferro , Trivellato Gabriel Franco , Rebech Gabriela Torres , Oliveira dos Santos Maciel Marilene , Melo Larissa Martins , Luvizotto Maria Cecília Rui , de Lima Valéria Marçal Felix 
Published: June 2018

SummaryEosinophils are traditionally associated with the immune response against helminth parasites. However, several studies have demonstrated that these cells have a role regarding protective immunity in leishmaniasis. Here, we examined the relationship between the presence of eosinophils and parasite load in biopsy samples from dogs, obtained through fine needle puncture and aspiration of lymph nodes. Histological slides containing biopsy material from lymph nodes of dogs with canine visceral leishmaniasis and healthy dogs were used to obtain baseline eosinophil counts. Subsequently, scrapings were taken from slides for DNA extraction and determination of parasite load, using real‐time PCR (qRT‐PCR). Additionally, production of nitric oxide (NO) and reactive oxygen species (ROS) levels by eosinophils in the peripheral blood of dogs with canine visceral leishmaniasis and healthy dogs was measured. The eosinophil percentage were higher in lymph nodes of infected group, and the parasite load showed a significant negative correlation with the eosinophil count. The production of NO and ROS by eosinophils in the peripheral blood was higher in the dogs with canine visceral leishmaniasis. All the results together suggest that eosinophils may participate in antileishmanial immunity in canine visceral leishmaniasis.
How Do Socially Distinctive Newcomers Fare? Evidence from a Field Experiment
Authors: Andersen Simon Calmar , Moynihan Donald P. 
Published: June 2018

Abstract
New hires offer a mixed blessing. They can spur teams to reflect on their processes in ways that encourage learning. But organizational newcomers may also struggle to achieve inclusion. This article examines how newcomers' experiences in public organizations depend on their social distinctiveness. While diversity is usually framed in terms of biodemographic factors such as race and gender, educational background is another form of social distinction. Educational differences may trigger psychological responses such as negative social categorization and serve as an observable criterion by which professional status and power are allocated. Using a field experiment, schools were provided two types of new hires: those who shared the educational background of existing teams and more socially distinctive newcomers. Both types of newcomers led to heightened team reflection processes relative to a control group. However, old‐timers were less accepting of educationally distinct newcomers, viewing them as less competent and cooperative.
Ferredoxin/thioredoxin system plays an important role in the chloroplastic NADP status of Arabidopsis
Authors: Hashida Shin‐nosuke , Miyagi Atsuko , Nishiyama Maho , Yoshida Keisuke , Hisabori Toru , Kawai‐Yamada Maki 
Published: June 2018

SummaryNADP is a key electron carrier for a broad spectrum of redox reactions, including photosynthesis. Hence, chloroplastic NADP status, as represented by redox status (ratio of NADPH to NADP+) and pool size (sum of NADPH and NADP+), is critical for homeostasis in photosynthetic cells. However, the mechanisms and molecules that regulate NADP status in chloroplasts remain largely unknown. We have now characterized an Arabidopsis mutant with imbalanced NADP status (inap1), which exhibits a high NADPH/NADP+ ratio and large NADP pool size. inap1 is a point mutation in At2g04700, which encodes the catalytic subunit of ferredoxin/thioredoxin reductase. Upon illumination, inap1 demonstrated earlier increases in NADP pool size than the wild type did. The mutated enzyme was also found in vitro to inefficiently reduce m‐type thioredoxin, which activates Calvin cycle enzymes, and NADP‐dependent malate dehydrogenase to export reducing power to the cytosol. Accordingly, Calvin cycle metabolites and amino acids diminished in inap1 plants. In addition, inap1 plants barely activate NADP‐malate dehydrogenase, and have an altered redox balance between the chloroplast and cytosol, resulting in inefficient nitrate reduction. Finally, mutants deficient in m‐type thioredoxin exhibited similar light‐dependent NADP dynamics as inap1. Collectively, the data suggest that defects in ferredoxin/thioredoxin reductase and m‐type thioredoxin decrease the consumption of NADPH, leading to a high NADPH/NADP+ ratio and large NADP pool size. The data also suggest that the fate of NADPH is an important influence on NADP pool size.
Heterogeneous effects of competitiveness shocks on macroeconomic performance across euro area countries
Authors: Staehr Karsten , Vermeulen Robert 
Published: June 2018

AbstractThis paper considers how competitiveness impacts macroeconomic performance in 11 euro area countries. VAR models are estimated for the individual countries using quarterly data from 1995Q4 to 2013Q4. Besides unit labour costs as a competitiveness measure, the models include GDP, the current account balance and domestic credit. The empirical analyses show that changes in unit labour costs help explain GDP dynamics in the short and medium term in most countries, whereas they have little explanatory power for the current account balance or domestic credit for most countries. Overall, the effects of the unit labour costs vary substantially across the countries in the euro area. The heterogeneity suggests that policy measures aiming to improve economic growth, correct current account imbalances and ensure financial stability need to take country‐specific features into account.