bluuebunny/crossref_metadata_2025_split huggingface dataset:
A3B Porphyrins Bearing Thienyl/Pyridyl Moieties Obtained via Scrambling: Characterization, DNA interaction and Anticancer Studies
Authors: Ramesh Jagadeesan , Arunkumar Chellaiah , Sujatha Subramaniam 
Published: October 2018

AbstractCondensation of 3‐pyridine carboxaldehyde with 2/3‐thienyl dipyrromethanes in presence of acid catalyst gives 5‐(3′‐pyridyl)‐10,15,20‐tri(2/3‐thienyl)porphyrins (S1a and S2a) due to scrambling along with the expected trans‐porphyrins. The corresponding copper(II) and zinc(II) porphyrins were also synthesized. Moreover, to study their biological properties their cationic derivatives were obtained. All the complexes were characterized by UV‐Vis, fluorescence, NMR spectroscopy, mass spectrometry and cyclic voltammetry. The cationic porphyrins bind with DNA non‐intercalatively; show singlet oxygen mediated photocleavage; phototoxic to A549 lung cancer cells through apoptotic pathway.
Homochiral Metal Organic Frameworks and Their Usage for the Enantio‐Purification of Racemic Drugs
Authors: Ullah Shakir , Yunus Uzma , Bhatti Moazzam H. , Southon Peter D. , Iqbal Kiran , Zaidi Sadia 
Published: October 2018

AbstractThree new homochiral MOFs (MOF‐808‐S‐ibuprofen, MOF‐808‐S‐proline and MOF‐808‐S‐lactic acid) were synthesized via the post synthetic modification of achiral MOF‐808 and were characterized by various analytical tools. The new homochiral MOFs (HCMOFs) were examined for the enantioselective adsorption of racemic drugs. The n‐hexane solution of racemic ibuprofen, ketoprofen and flurbiprofen were allowed to adsorb in the chiral channels of the HCMOFs. The drugs were desorbed form porous HCMOFs and analysed by chiral HPLC. MOF‐808‐S‐ibuprofen selectively adsorbed R‐ibuprofen and R‐ketoprofen with enantiomeric excess (ee) of 50 and 56% respectively.
Synthesis of Novel Structure Based Low Generation Branched Salicylaldimine Nickel Complexes and Their Catalysis of Ethylene Oligomerization
Authors: Zhang Na , Fu Zijian , Jiang Yan , Guo Daizong , Chen Liduo , Wang Jun 
Published: October 2018

AbstractA series of salicylaldimine nickel complexes bearing low generation branched molecules with naphthenic, straight and branched chain as cores have been synthesized by one‐pot method in high yield and were characterized by NMR spectroscopy, infrared spectroscopy, mass spectrometry and elemental analysis. The complexes C1‐C3 could form active catalysts in ethylene oligomerization reactions upon activation with co‐catalyst methylaluminoxane (MAO), triethylaluminium (AlMe3), ethylaluminum sesquichloride (EASC), AlEtCl2 or AlEt2Cl. The catalytic performance was affected by reaction conditions such as reaction temperature, ethylene pressure, Al/Ni molar ration and reaction time. The catalytic activity could reach up to 105 oligomer mol−1 (Ni) h−1 and the products were C4, C6, C8 and trace higher carbon olefins (C10‐C18) under the optimum reaction conditions. When AlEt3 was used as co‐catalyst, the major product was C4 olefin. However the tandem reaction of ethylene oligomerization and Friedel‐Crafts occurred as chlorinated alkylaluminum reagents were used as co‐catalyst. In addition, the catalytic result showed that the kind of substituent groups in cores of branched salicylaldimine nickel complexes had a significant effect on the catalytic activity, and the distribution of ethylene oligomerization products was affected by co‐catalyst and solvent.
Stress and sleep remain significant predictors of health after controlling for negative affect
Authors: Benham Grant , Charak Ruby 
Published: October 2018

AbstractPrior research has shown that the predictive power of a stress–health model can be improved by the addition of sleep as a predictor variable. However, negative affect (NA) may act as a confounding variable in stress–health relationships: a source of bias that potentially inflates the observed relationship between stress and health. The current study examines whether stress and sleep remain significant predictors of health after controlling for trait NA. An online survey containing well‐established measures of stress, sleep, health, and NA was completed by 460 undergraduates. Hierarchical regression analyses revealed that stress and sleep remained significant predictors of self‐reported health after controlling for the effects of NA. Our findings support the notion that stress–health models can be improved by the integration of sleep as an additional predictor variable and demonstrate that the stress/sleep–health relationships are not fully explained by dispositional NA. From a theoretical perspective, the inclusion of NA measures allows researchers to tease apart the unique contributions of predictor variables. This knowledge can subsequently be put to the test with greater confidence in the design of interventions that seek to improve health through stress reduction and improved sleep.
A NanoFlare‐Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy
Authors: Yan Rong , Chen Jie , Wang Jianhao , Rao Jiaming , Du Xuancheng , Liu Yongming , Zhang Leshuai , Qiu Lin , Liu Bo , Zhao Yuan‐Di , Jiang Pengju , Chen Chunying , Li Yong‐Qiang 
Published: October 2018

AbstractAccurate tumor margin demarcation in situ remains a paramount challenge. Herein, a NanoFlare (also known as spherical‐nucleic‐acid technology) based strategy is reported for in situ tumor margin delineation by transforming and amplifying the pathophysiological redox signals of tumor microenvironment. The NanoFlare designed (named AuNS‐ASON) is based on gold nanostar (AuNS) coated with a dense shell of disulfide bridge‐inserted and cyanine dyes‐labeled antisense oligonucleotides (ASON) targeting survivin mRNA. The unique anisotropic ASON‐spike nanostructure endows the AuNS‐ASON with universal cellular internalization of tumor cells, while the disulfide bridge inserted confers response specificity toward redox activation. In vitro experiments demonstrate that the AuNS‐ASON can discriminate tumor cells rapidly with activated fluorescence signals (>100‐fold) in 2 h, and further achieve synergistic gene/photothermal tumor cells ablation upon near‐infrared laser irradiation. Remarkably, in situ tumor margin delineation with high accuracy and outstanding spatial resolution (<100 µm) in mice bearing different tumors is obtained based on the AuNS‐ASON, providing intraoperative guidance for tumor resection. Moreover, the AuNS‐ASON can enable efficient neoadjuvant gene/photothermal therapy before surgery to reduce tumor extent and increase resectability. The concept of NanoFlare‐based microenvironment signal transformation and amplification could be used as a general strategy to guide the design of activatable nanoprobes for cancer theranostics.
An empirical study on how project context impacts on code cloning
Authors: Perez‐Castillo Ricardo , Piattini Mario 
Published: October 2018

AbstractCode cloning can seriously affect software quality. Code clones are various fragments of syntactically or semantically equivalent code. Some authors argue that code clones have a negative impact on maintainability and understandability, since clones propagate defects and make it mandatory to pay attention to several copies. However, other authors believe clones are not necessarily bad, since self‐admitted clones favor system stability and allow developers to move projects forward. Although some root causes and effects of cloning have been widely studied, there is not much relevant work analyzing how certain projects context factors impact on code cloning. This work presents an empirical validation of six open source projects by considering certain factors from Git repositories measured throughout a total of 70 releases for the 6 systems. The factors analyzed were the number of commits and committers per release, the average size of the commits and the size of the system in each release. The main conclusion obtained from the study is that, while the number of commits and committers and the system size do not significantly affect cloning, larger commits lead to a higher cloning ratio. These insights contribute to predicting and preventing code cloning, thus enabling a software quality improvement.
Monitoring Fast, Voxel‐Scale Cure Kinetics via Sample‐Coupled‐Resonance Photorheology
Authors: Fiedler‐Higgins Callie I. , Cox Lewis M. , DelRio Frank W. , Killgore Jason P. 
Published: October 2018

AbstractPhotopolymerizable materials are the focus of extensive research across a variety of fields ranging from additive manufacturing to regenerative medicine. However, poorly understood material mechanical and rheological properties during polymerization at the relevant exposure powers and single‐voxel length‐scales limit advancements in part performance and throughput. Here, a novel atomic force microscopy (AFM) technique, sample‐coupled‐resonance photorheology (SCRPR), to locally characterize the mechano‐rheological properties of photopolymerized materials on the relevant reaction kinetic timescales, is demonstrated. By coupling an AFM tip to a photopolymer and exposing the coupled region to a laser, two fundamental photopolymerization phenomena: (1) timescales of photopolymerization at high laser power and (2) reciprocity between photodose and material properties are studied. The ability to capture rapid kinetic changes occurring during polymerization with SCRPR is demonstrated. It is found that reciprocity is only valid for a finite range of exposure powers in the verification material and polymerization is highly localized in a low‐diffusion system. After polymerization, in situ imaging of a single polymerized voxel is performed using material‐appropriate topographic and nanomechanical modalities of the AFM while still in the as‐printed environment.
Biomimetic Graphite Foils with High Foldability and Conductivity
Authors: Wu Mingmao , Zhang Miao , Ma Hongyun , Qu Liangti , Li Chun 
Published: October 2018

AbstractGraphite foils have displayed a large potential in a variety of applications. However, their poor mechanical performance strongly limits their applications in flexible devices. Here, a hierarchical nacre‐like graphite foil with greatly improved mechanical properties (tensile strength: 54 MPa, toughness: 513 kJ m−3) and high conductivity (1400 S cm−1) is reported. The biomimetic graphite foil has a brick‐and‐mortar‐like structure with exfoliated expanded graphite (EEG) platelets as bricks and reduced graphene oxide (rGO) as mortar, in which rGO sheets efficiently fill the interspaces and voids between EEG platelets and bridge the adjacent EEG platelets, synergistically reinforcing its mechanical performance and enhancing its conductivity. When evaluated as a current collector for flexible and foldable supercapacitors, the device delivers a long cycle life over 5000 cycle folding tests with 100% capacitance retention. The biomimetic graphite foil provides a new material platform for flexible and wearable electronic devices.
Controlled Synthesis and Photonics Applications of Metal Halide Perovskite Nanowires
Authors: Zhang Xuehong , Chen Shula , Wang Xiao , Pan Anlian 
Published: October 2018

AbstractMetal halide perovskite nanowires (NW)s have recently demonstrated potential applications in integrated photonics devices such as lasers and photodetectors due to their unique physical and chemical characteristics. Here, the rapid progress in the synthesis methods and photonics applications of organic–inorganic hybrid and all‐inorganic halide perovskite NWs are reviewed systematically. The controlled synthesis methods are mainly classified into solution‐phase synthesis, vapor‐phase synthesis, and other synthesis methods. The photonics applications of the halide perovskite NWs, including lasers, photodetectors, solar cells, and other applications, are also introduced and discussed. Finally, the summary and perspectives for halide perovskite NWs are provided.
Advances in Ink‐Jet Printing of MnO2‐Nanosheet Based Pseudocapacitors
Authors: ten Elshof Johan E. , Wang Yang 
Published: October 2018

AbstractAn overview of recent progress in the development of 2D manganese oxide nanosheet‐based pseudocapacitors is provided, with emphasis on underlying methods and strategies. 2D manganese oxide nanosheets are sheet‐like monocrystallites of ≈0.5 nm thickness and lateral dimensions of 50–5000 nm. MnO2 nanosheets are synthesized in the form of colloids, which can be readily utilized in wet‐chemical processes like ink‐jet printing. The synthetic strategies to make 2D δ‐MnO2 nanosheets by bottom‐up and top‐down approaches are discussed, and the relationship between the ionic defect structure of δ‐MnO2 nanosheets and their pseudocapacitance is explained. The basic principles and experimental challenges of ink‐jet printing of 2D materials at high resolution, and the development of 2D nanosheet‐based inks are discussed, with emphasis on δ‐MnO2, graphene, and graphene oxide. The fabrication and performance of δ‐MnO2 nanosheet derived pseudocapacitors, including ink‐jet printed flexible microsupercapacitors, is described. The relationship between the electrode thickness and layer architecture and the specific capacitance is explained.
Bromodomain Drug Discovery – the Past, the Present, and the Future
Authors: Pervaiz Mehrosh , Mishra Pankaj , Günther Stefan 
Published: October 2018

AbstractWith the bromodomain (BRD) inhibitor JQ1, a remarkable success story of BRD4 as a novel drug target has been set off that yielded many anti‐cancer drugs that are now in clinical trials. But not all of the great prospects of BRDs as drug targets may become true. First evaluations of ongoing clinical trials revealed that treatment with BET‐inhibitors can be accompanied with significant toxic side effects and the validation of the therapeutic benefit of BET‐inhibitors compared to existing therapies is still pending. New strategies that may overcome possible obstacles in BRD drug discovery include combination therapies with other agents, dual target inhibitors, and proteolysis targeting chimeras (PROTACs). Furthermore, non‐BET proteins seem promising drug targets as well. Most recently, BRDs have been identified as putative targets to treat parasitic diseases such as malaria. Milestones in BRD drug discovery are reviewed and promising new developments are evaluated.
Identifying the best practices of airlines’ green operations strategy: A cross‐regional worldwide survey
Authors: Migdadi Yazan Khalid Abed‐Allah 
Published: October 2018

AbstractThe aim of this paper is to report the best practices of airlines’ green operations strategies throughout the world by surveying airlines from different regions. To realize this goal, a sample of 23 airlines from different regions (North America, South America, Europe, Asia, and the Middle East) was surveyed. The sample suited the availability of the secondary published data. For the study, the annual sustainability reports of surveyed airlines from the period of 2013 to 2016 were reviewed. The reports were retrieved from the Global Reporting Initiative website and from airline websites. To gain insight into the best practices, two analytical approaches were adopted: cross‐sampling and cluster analysis. The study revealed that the best practices are related to several green indicators, and the actions in best practice were closer to process‐oriented than to technology‐oriented actions. This is one of a very few studies to report the best practices in green operations strategy over time by airlines at the global level.
Government of India Policy of Fixing Minimum Support Price for Agriculture Products in relation to Water Resources of Peninsular India
Authors: Sawkar R. H. , Joshi Mukund , Swaminath M. H. , Guruprasad G. 
Published: October 2018

ABSTRACT
85% of water resources is used in agriculture. Price of water is not taken into account while declaring the Minimum Support Price (MSP) for different crops by Government of India (GoI). Origin of water, depletion of groundwater table and its effect on sea level changes and climate are discussed with reference to geomorphology of Sahyadri hill range, where both east and west flowing rivers of peninsular India take their origin. New price based on incentive to be given to farmers who take up growing crops using less water compared to rice and sugarcane is suggested.
Assessment of Vulnerability of Rock Slope Considering Material and Seismic Variability
Authors: Roy Nishant , Sarkar Rajib , Sarkar Kripamoy , Jat Mahesh Kumar , Fulwaria Gaurav 
Published: October 2018

ABSTRACT
Stability analysis of rock slopes has always been a critical and challenging task for the geotechnical engineering professionals. The complexities associated with the stability analysis arise due to the heterogeneous, anisotropic and variable nature of the rock mass. Assessment of slope stability becomes further challenging under earthquake motions which are random in nature. Thus, uncertainties in both material and loading parameters are required to be considered for a robust assessment of the vulnerability of slopes in geologically complex and seismically active regions.
In the present study, the influence of variability in geological properties on the slope stability has been considered within the framework of First Order Reliability Method (FORM). Reliability analysis has been performed for a typical slope profile using the Response Surface Method (RSM) and FORM leading to the identification of critical design parameters along with the quantification of the system performance in terms of reliability index. Subsequently, dynamic time history analyses have been performed for generating the seismic fragility curves of the rock slope as a function of increasing earthquake intensity. Thus, the study attempts to present a methodology for assessing the vulnerability of a rock slope with due consideration of the variation in both the material properties and seismic loading.
Cross-Association Analysis of Barren Measures Lithologies and Microfacies, Talcher Coalfield, Odisha
Authors: Hota Rabindra Nath 
Published: October 2018

ABSTRACT
Cross-association analysis of lithologies and microfacies of two borehole sections of the Barren Measures Formation, Talcher coalfield situated 12 km apart show strikingly dissimilar results. In case of lithologies, one-to-one correlation becomes significant, which suggests continuity of the formation throughout the Barren Measures Formation and prevalence of braided stream depositional environment. However, lack of significant correlation of microfacies suggests existence of different sub-environments at different parts of the Barren Measures Formation during each stage of sedimentation. When channel facies were laid down at one place, homotaxial leeve, floodplain and swamp facies were deposited elsewhere.
Oil Shale Prospects of Imo Formation Niger Delta Basin, Southeastern Nigeria: Palynofacies, Organic Thermal Maturation and Source Rock Perspective
Authors: Kingsley Okeke Kachikwulu , Umeji Obianuju P. 
Published: October 2018

ABSTRACT
The search for oil and gas in the Nigerian inland basins and efficacy of the unconventional oil shale in hydrocarbon generation have necessitated the palynofacies characterization, thermal maturation and source rock evaluation of the Imo Formation, updip Niger Delta basin to determine its palynofacies constituents and oil shale potential. The standard acid maceration technique, palynofacies description as well as palynomorph colour index chart systematically compared to thermal alteration index and vitrinite reflectance index values were utilized for the study.
The palynofacies components of the Imo Formation is dominant of yellow and brown amorphous organic matter, marine taxa, opaque particles, with few dark brown structured phytoclasts and terrestrial microflora. The source rock content is interpreted as Kerogen Type II - oil prone with abundant marine palynomorphs, amorphous organic matter and few terrestrial microfossils. The spore/pollen colour of the strata is light brown signifying mature and oil generation zone. This correlates to thermal alteration index (TAI) 2+ to 3 and vitrinite reflectance index (%Ro) values of 0.5% to 1.0%.
The abundance of the amorphous organic matter of marine origin suggests good source rock which indicates good oil shale prospects. The oil shale prospects of the Imo Formation in the study area are hindered by the low abundance of the palynofacies associations. Field evidence indicate that the grey to slightly light grey shales in hand specimen, as against black carbonaceous shales rich in organic matter suggests that the environmental conditions affected the quality of the organic kerogen. The oil yields may be compensated by the great volume of marine shale deposited in the formation and the abundance of amorphous organic matter of marine origin which is known to be an excellent indicator of oil. The palynofacies model enhances the understanding of palynofacies events and oil shale quality which can be tied to the development of unconventional oil shale, oil fields and subsequent exploration drive in the area.
Venous Thromboembolism is Associated With Lack of Vitamin D Supplementation in Patients With Spinal Cord Injury and Low Vitamin D Levels
Authors: Ehsanian Reza , Timmerman Molly A. , Wright Jerry M. , McKenna Stephen , Dirlikov Ben , Crew James 
Published: October 2018

BackgroundThe role of vitamin D in the pathogenesis of venous thromboembolism (VTE) and prevalence of low vitamin D (LVitD) in spinal cord injury (SCI) has motivated vitamin D testing and supplementation. This is an exploratory study of data collected at a time before the routine clinical practice of vitamin D supplementation, allowing for evaluation of the natural history of vitamin D levels in patients with SCI.ObjectiveTo determine if vitamin D supplementation in persons with SCI and LVitD levels is associated with decreased prevalence of VTE.DesignRetrospective cohort study.SettingRehabilitation Center at a Level I Trauma Center.ParticipantsPatients with SCI admitted to acute inpatient rehabilitation (N = 282).Main Outcome MeasuresVTE prevalence in patients with LVitD levels, grouped by presence or absence of vitamin D supplementation.ResultsOf the acute inpatient SCI population, 80% (227/282) of patients demonstrated vitamin D levels <30 ng/mL (LVitD). Although the incidence of VTE was almost double in the LVitD group, 19% (43/227) of the patients in the LVitD group had VTE versus 9% (5/55) of patients with vitamin D levels ≥30 ng/mL (normal VitD [NVitD]); this difference was not statistically significant (P = .108, Cramer's V = .104). When the role of vitamin D supplementation was analyzed, individuals in the LVitD group who received no vitamin D supplementation (LVitDSuppNegative) had a higher incidence of VTE (statistically significant) compared to the LVitD group with vitamin D supplementation (LVitDSuppPositive) (24% [42/178] vs. 2% [1/49]) (P < .001, Cramer's V = .226). In post hoc exploratory analyses, the VTE rate of patients in the LVitDSuppNegative group was noted to be significantly higher than that in all other patient groups combined (P < .001, Cramer's V = .229). A binary logistic regression model incorporating clinical covariates also showed this grouping to be significant.ConclusionA significant association appears to exist between lack of vitamin D supplementation and VTE occurrence in persons with acute SCI and LVitD levels.Level of EvidenceIII