bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors
Authors: Sheehan Jason , Kondziolka Douglas , Flickinger John , Lunsford L. Dade 
Published: November 2018

Object. Lung carcinoma is the leading cause of death from cancer. More than 50% of those with small cell lung cancer develop a brain metastasis. Corticosteroid agents, radiotherapy, and resection have been the mainstays of treatment. Nonetheless, median survival for patients with small cell lung carcinoma metastasis is approximately 4 to 5 months after cranial irradiation. In this study the authors examine the efficacy of gamma knife surgery for treating recurrent small cell lung carcinoma metastases to the brain following tumor growth in patients who have previously undergone radiation therapy, and they evaluate factors affecting survival.
Methods. A retrospective review of 27 patients (47 recurrent small cell lung cancer brain metastases) undergoing radiosurgery was performed. Clinical and radiographic data obtained during a 14-year treatment period were collected. Multivariate analysis was utilized to determine significant prognostic factors influencing survival.
The overall median survival was 18 months after the diagnosis of brain metastases. In multivariate analysis, factors significantly affecting survival included: 1) tumor volume (p = 0.0042); 2) preoperative Karnofsky Performance Scale score (p = 0.0035); and 3) time between initial lung cancer diagnosis and development of brain metastasis (p = 0.0127). Postradiosurgical imaging of the brain metastases revealed that 62% decreased, 19% remained stable, and 19% eventually increased in size. One patient later underwent a craniotomy and tumor resection for a tumor refractory to radiosurgery and radiation therapy. In three patients new brain metastases were demonstrating on follow-up imaging.
Conclusions. Stereotactic radiosurgery for recurrent small cell lung carcinoma metastases provided effective local tumor control in the majority of patients. Early detection of brain metastases, aggressive treatment of systemic disease, and a therapeutic strategy including radiosurgery can extend survival.
Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience
Authors: Liu Dong , Xu Desheng , Zhang Zhiyuan , Zhang Yipei , Zheng Ligao 
Published: November 2018

ObjectThe authors sought to assess the results of Gamma Knife surgery (GKS) in patients with vestibular schwannomas (VSs).MethodsSeventy-four consecutive patients (33 men and 41 women) were evaluated by means of serial imaging studies, clinical examinations, and questionnaires. Nineteen patients had undergone resection of their VS. Facial nerve function was normal in 63 patients (85.1%) before GKS, and 63.5% of them had useful hearing. The prescription peripheral dose varied between 10 and 14 Gy (mean 12.27 ± 0.96 Gy); the corresponding central dose was 21 to 30 Gy (mean 24.9 ± 2.18 Gy). The mean volume of the tumor at GKS was 10.79 ± 5.52 ml (range 0.11–27.8 ml). A mean of eight isocenters (range 3–17) was used for treating these lesions.At a median follow-up period of 68.3 months (range 30–122 months), tumor shrinkage was observed in 60 patients (81.1%), and the tumor size was stable in 11 (14.8%). Persistent neuroimaging demonstrated evidence of progression in only three patients (4.1%): two underwent repeated GKS after an interval of 18 months and one continues to be observed. Five patients experienced trigeminal dysfunction: in three the dysfunction was transient and in the other two the dysfunction persists. Three patients suffered facial palsy. Useful hearing was preserved in 34 patients. Thirteen patients experienced some degree of hearing improvement. Deterioration of hearing was found in 13 of 62 patients who had Class I or II hearing before treatment.Conclusions Gamma Knife surgery prevents tumor growth; it achieves excellent neurological function preservation and produces few treatment-related complications.
Intracranial glomus jugulare tumors: volume reduction with Gamma Knife surgery
Authors: Feigl Guenther Christian , Horstmann Gerhard A. 
Published: November 2018

ObjectGlomus jugulare tumors (GJTs) are slow-growing benign tumors arising from paraganglion cells of the superior vagal ganglion. Involvement of cranial nerves and extensive erosion of the jugular foramen and petrous bone are typically seen in patients with GJTs. Advances in microsurgical techniques have improved patient outcomes, but tumors involving the petrous bone remain difficult to treat effectively. The aim of our study was to further evaluate the role of Gamma Knife surgery (GKS) in the management of intracranial GJTs.MethodsTwelve consecutive patients (mean age 51.7 years) with intracranial GJTs were included in this study. The treatment strategy was either multimodal, with microsurgical tumor volume reduction followed by GKS in patients suffering from brainstem compression, or GKS as the only treatment. Follow-up examinations included thorough neurological examinations and neuroradiological quantitative volumetric tumor analysis. Five patients (41.6%) underwent microsurgery before GKS. Tumor volumes ranging from 1.6 to 24.8 cm3 were treated using prescription doses of 14 to 20 Gy (nine–28 isocenters). The achieved overall tumor control rate after GKS was 100% (33 months mean follow up) with only mild side effects observed. A tumor volume reduction (mean 41.1%; 3.2 cm3) was achieved in all patients.Conclusions Gamma Knife surgery is a safe and effective treatment for intracranial GJTs. The tumor volume reductions achieved are comparable to those achieved using microsurgery but with a much lower rate of side effects. More studies with longer follow-up times are necessary to confirm these very promising results.
Geometrical accuracy of a 3-tesla magnetic resonance imaging unit in Gamma Knife surgery
Authors: Watanabe Yoichi , Lee Chung K. , Gerbi Bruce J. 
Published: November 2018

ObjectThe authors sought to evaluate and improve the geometrical accuracy of a 3-tesla magnetic resonance (MR) imaging unit used for Gamma Knife surgery (GKS).MethodsTo evaluate the geometrical accuracy of a Siemens Magnetom Trio 3-tesla MR imaging unit, two phantoms were used. Both phantoms were imaged with computed tomography (CT), a 1.5-tesla MR imaging unit (Siemens Avanto), and the 3-tesla MR imaging unit. A pair of orthogonal films was obtained with a radiotherapy simulator to validate the spatial coordinates of the marker positions determined with CT. The coordinates of the markers were measured using the GammaPlan treatment planning software. Magnetic resonance imaing was performed using three-dimensional (3D) magnetization-prepared rapid acquisition gradient echo (MPRAGE) and fast low-angle shot sequence (FLASH) pulse sequences. The voxel size was 1 × 1 × 1 mm3.Conclusions The root-mean-square error of MR images was 2 ± 0.73 mm for 3D MPRAGE. The error was reduced to 1.5 ± 0.64 mm for FLASH. The errors were decreased further by applying an image distortion correction method (the field-of-view filter) to the images acquired with FLASH. The mean errors were 1.3 ± 0.39 mm and 1.5 ± 0.77 mm for the two phantoms. The errors increased from 1 mm to 3.1 mm as the measurement points approached the caudal edge of the head coil (larger z value). Proper selection of a pulse sequence together with a geometrical distortion correction improved the geometrical accuracy of MR images. However, further study is needed to increase the geometrical accuracy of 3-tesla MR imaging units for radiosurgical applications.
Radiosurgery of isolated cerebral vessels following administration of paclitaxel in the rat
Authors: Major Otto , Walton Lee , Goodden John , Radatz Matthias , Szeifert Georg Tamas , Hanzely Zoltan , Kocsis Bela , Nagy Zoltan , Kemeny Andras 
Published: November 2018

ObjectProgressive obliteration occurs in arteriovenous malformations (AVMs) after radiosurgery; however, the risk of hemorrhage remains until the obliteration process is complete. The authors sought to enhance the radiation effect and reduce the risk of hemorrhage by facilitating faster vessel obliteration. To that end, a combination of a lower radiation dose with the addition of a radiosensitizing agent was compared with the effect of a higher radiation dose alone.MethodsUsing a method described by Mulvany and Halpern, isometric myography measurements were made on isolated rat middle cerebral artery specimens. The vessels were treated with 200 Gy, 80 Gy, 50 Gy, 25 Gy, 20 Gy, or 15 Gy by using Gamma Knife surgery. Taxol (paclitaxel 3 mg/kg/body weight) was administered intravenously to the animals. Survival times posttreatment were 24 hours, 6 weeks, 12 weeks, 12 months, or 18 months. After dissection, the middle cerebral arteries were mounted on a small-vessel myograph, and contraction and relaxation studies were performed.In a second series of experiments these results were validated in human fibroblast culture. When the cultures were 75 to 80% colonized, the samples were treated in vitro with 60Co gamma radiation in similar doses with or without paclitaxel.Conclusions Constriction responses were generally decreased in the paclitaxel-treated vessels. Differences were significant at 6 weeks (p < 0.05) and at 1 year (p < 0.05). After 1 year, in the paclitaxel-treated groups vascular reactivity was completely abolished in vessels receiving 50 Gy. In comparison, it took 6 months longer (18 months) for this reaction to be abolished in vessels without paclitaxel treatment.In tissue cultures Giemsa staining and immunohistochemical reactions for p53, Ki-67, CD-34, and SMA antigens revealed marked fibroblast hypertrophy in all of the paclitaxel-treated groups. Paclitaxel-treated vessels demonstrated decreased reactivity at significantly earlier stages than vessels that had not been treated. It would appear that paclitaxel causes acceleration in the time course of the late biological effect of gamma radiation. This beneficial effect could be used in Gamma Knife surgery in patients with AVMs, thus reducing the risk of posttreatment hemorrhage.
Gamma Knife surgery targeting the centromedian nucleus of the thalamus for the palliative management of thalamic pain: durable response in stroke-induced thalamic pain syndrome
Authors: Keep Marcus F. , Mastrofrancesco Lois , Craig Arthur D. , Ashby Lynn S. 
Published: November 2018

✓The authors report the neuroimaging features, treatment planning, and outcome in a case of radiosurgical thalamotomy targeting the centromedian nucleus (CMN) for stroke-induced thalamic pain.A 79-year-old man, with embolic occlusion of the left middle cerebral artery and large hemispheric infarction involving the thalamus, suffered a right hemiplegia and expressive aphasia. One year poststroke, severe right-sided facial, scalp, arm, and trunk pain developed and was exacerbated by any tactile contact. Medical treatment had failed. Medical illness, including mandatory anticoagulation therapy for atrial fibrillation, precluded surgical procedures. Minimally invasive radiosurgery was offered as an alternative. Magnetic resonance imaging and computed tomography were used to localize the left CMN. A single shot of 140 Gy was delivered to the 100% isodose line by using the 4-mm collimator helmet.The patient was evaluated at regular intervals. By 12 weeks posttreatment, he had significant improvements in pain control and his ability to tolerate physical contact during activities of daily living. Magnetic resonance imaging demonstrated baseline encephalomalacia from his prior stroke, and signal changes in the left CMN consistent with gamma irradiation–based thalamotomy. Currently, nearly 7 years after radiosurgery, he continues to enjoy a marked reduction in pain without the need of analgesic medications.Thalamic pain syndrome is generally refractory to conventional treatment. Neurosurgical interventions provide modest benefit and carry associated risks of invasive surgery and anesthesia. The CMN is readily localized with neuroimaging and is an approximate target to reduce the suffering aspect of pain. In this case, radiosurgery was a safe and effective treatment, providing durable symptom control and improved quality of life.
Repeated Gamma Knife surgery for refractory trigeminal neuralgia
Authors: Huang Chuan-Fu , Chuang Jim-Chao , Tu Hsien-Tang , Lin Long-Yau 
Published: November 2018

ObjectRepeated Gamma Knife surgery (GKS) for trigeminal neuralgia (TN) is an acceptable method for refractory cases but not well established in terms of dose effect and nerve tolerance. The authors report their experience in 28 patients over 3.5 years of follow up.MethodsBetween 1999 and 2004, a total of 28 patients with recurrent or residual TN underwent repeated GKS. The median follow-up periods were 52 and 43 months after the first and repeated procedures, respectively. The entry zone of the trigeminal nerve was targeted using a 4-mm collimator and treated with 40 to 76 Gy as maximal dose. Additive doses ranged between 110 and 152 Gy. The median duration of symptoms was 4.86 years. There were 12 women (46%) and 16 men (54%).At the last evaluation, a total of 19 patients (68%) reported pain relief. Of these patients, 13 were no longer taking pain medications. Significant recurrent or residual pain was noted in nine patients after a median follow up of 12 months (range 6–48 months). New onset of facial numbness was noted in 10 patients. An additive dose above 115 Gy was found to be associated with facial numbness and nonfacial numbness (p = 0.047). No definite additive dose correlation with pain relief was noted (p = 0.23).Conclusions Repeated GKS established durable pain relief in a majority of patients, and a higher additive dose (> 115 Gy) tended to cause facial numbness. However, a prospective trial is needed to fully assess the efficacy and late complications of GKS.
Glioma and Alzheimer’s Disease
Authors: Lehrer Steven 
Published: November 2018

Background: Cancer mortality and Alzheimer’s disease (AD) mortality increase with age, but some studies have shown an inverse relationship of the two diseases, that is, older persons with cancer have a reduced risk of AD and vice versa. However, other analyses suggest that AD and brain tumor might be positively correlated. Objective: In the current study, we wished to determine the relationship of AD mortality to malignant brain tumor mortality in US states and counties. Methods: Data and maps of malignant brain tumor mortality and Alzheimer’s disease mortality (1999–2016) are from the CDC Wonder tool (https://wonder.cdc.gov/cmf-icd10.html). Data on malignant brain tumor types and their frequencies are from the Surveillance, Epidemiology, and End Results Program (SEER, https://seer.cancer.gov). Data on the genetics of lower grade glioma are from the TCGA Lower Grade Glioma (LGG) dataset in TCGA (The Cancer Genome Atlas). Results: SEER data indicate that astrocytomas make up 58.2% of malignant brain tumors in patients 65 and older; glioblastoma and anaplastic astrocytoma make up 41.6%. We found a significant positive correlation between AD mortality rate and malignant brain tumor mortality rate 1999–2016 in persons age 65 and older in A) 1,101 US counties, p <  0.001 and B) 50 US states, p <  0.001. Conclusion: Adult malignant brain tumors may share some environmental risks with AD. Malignant brain tumors and AD also have some genes in common: TREM2, SPI1, CD33, and INPP5D. The interaction of environment and genetics is complex and overlaps in malignant brain tumors and AD.
Multi-Objective Optimization of Wire Electro Discharge Machining (WEDM) Process Parameters Using Grey-Fuzzy Approach
Authors: Das Partha Protim , Diyaley Sunny , Chakraborty Shankar , Ghadai Ranjan Kumar 
Published: November 2018

Wire electro discharge machining (WEDM) is a versatile non-traditional machining process that is extensively in use to machine the components having intricate profiles and shapes. In WEDM, it is very important to select the optimal process parameters so as to enhance the machine performance. This paper emphasizes the selection of optimal parametric combination of WEDM process while machining on EN31 steel, using grey-fuzzy logic technique. Process parameters such as servo voltage, wire tension, pulse-on-time and pulse-off-time were considered while taking into account several multi-responses such as material removal rate (MRR) and surface roughness (SR). It was found that pulse-on-time of 115 µs, pulse-off-time of 35 µs, servo voltage of 40 V and wire tension of 5 kgf results in a larger value of grey fuzzy reasoning grade (GFRG) which tends to maximize MRR and improve SR. Finally, analysis of variance (ANOVA) is applied to check the influence of each process parameters in the estimation of GFRG.
The Stellar Membership of the Taurus Star-forming Region*
Authors: Luhman K. L. 
Published: November 2018

Abstract
The high-precision astrometry from the second data release of the Gaia mission has made it possible to greatly improve the census of members of nearby clusters and associations. I have applied the Gaia data to the Taurus star-forming region, refining the sample of known members and identifying candidates for undiscovered members. The resulting samples of members and candidates provide the best constraints to date on the distribution of ages and the initial mass function (IMF) in Taurus. Several studies over the last 30 years have proposed the existence of a population of older stars (≳10 Myr) that is associated with the Taurus clouds. The data from Gaia demonstrate that such a population does not exist. Meanwhile, previous IMF estimates for small fields surrounding the Taurus aggregates have exhibited a surplus of K7–M0 stars (0.7–0.8 M
⊙) relative to star-forming clusters such as IC 348 and the Orion Nebula Cluster. However, that difference disappears when the new census of the entire region is considered, which should be complete for spectral types earlier than M6–M7 at A

J
< 1. Thus, there is little variation in the stellar IMF across the 3–4 orders of magnitude in stellar density that are present in nearby star-forming regions. Finally, I note that the proper motions of two previously known members, KPNO 15 and 2MASS J04355209 + 2255039, indicate that they may have been ejected from the same location within the L1536 cloud ∼7200 years ago.
Searching for Subsecond Stellar Variability with Wide-field Star Trails and Deep Learning
Authors: Thomas David , Kahn Steven M. 
Published: November 2018

Abstract
We present a method that enables wide-field ground-based telescopes to scan the sky for subsecond stellar variability. The method has operational and image processing components. The operational component takes star trail images. Each trail serves as a light curve for its corresponding source and facilitates subexposure photometry. We train a deep neural network to identify stellar variability in wide-field star trail images. We use the Large Synoptic Survey Telescope Photon Simulator to generate simulated star trail images and include transient bursts as a proxy for variability. The network identifies transient bursts on timescales down to 10 ms. We argue that there are multiple fields of astrophysics that can be advanced by the unique combination of time resolution and observing throughput that our method offers.
Fast and Slow Paths to Quiescence: Ages and Sizes of 400 Quiescent Galaxies from the LEGA-C Survey
Authors: Wu 吳柏 Po-Feng 鋒 , Wel Arjen van der , Bezanson Rachel , Gallazzi Anna , Pacifici Camilla , Straatman Caroline M. S. , Barišić Ivana , Bell Eric F. , Chauke Priscilla , Houdt Josha van , Franx Marijn , Muzzin Adam , Sobral David , Wild Vivienne 
Published: November 2018

Abstract
We analyze the stellar age indicators (D
n
4000 and EW(Hδ)) and sizes of 467 quiescent galaxies with M
* ≥ 1010
M
⊙ at z ∼ 0.7 drawn from DR2 of the LEGA-C survey. Interpreting index variations in terms of equivalent single stellar population age, we find that the median stellar population is younger for larger galaxies at fixed stellar mass. The effect is significant, yet small; the ages of the larger and smaller subsets differ by only <500 Myr, much less than the age variation among individual galaxies (∼1.5 Gyr). At the same time, post-starburst galaxies—those that experienced recent and rapid quenching events—are much smaller than expected based on the global correlation between age and size of normal quiescent galaxies. These coexisting trends unify seemingly contradictory results in the literature; the complex correlations between size and age indicators revealed by our large sample of galaxies with high-quality spectra suggest that there are multiple evolutionary pathways to quiescence. Regardless of the specific physical mechanisms responsible for the cessation of star formation in massive galaxies, the large scatter in D
n
4000 and EW(Hδ) immediately implies that galaxies follow a large variety of evolutionary pathways. On the one hand, we see evidence for a process that slowly shuts off star formation and transforms star-forming galaxies to quiescent galaxies without necessarily changing their structures. On the other hand, there is likely a mechanism that rapidly quenches galaxies, an event that coincides with dramatic structural changes, producing post-starburst galaxies that can be smaller than their progenitors.
Accurate OH Maser Positions. II. The Galactic Center Region
Authors: Qiao Hai-Hua , Walsh Andrew J. , Breen Shari L. , Gómez José F. , Dawson J. R. , Imai Hiroshi , Ellingsen Simon P. , Green James A. , Shen Zhi-Qiang 
Published: November 2018

Abstract
We present high spatial resolution observations of ground-state OH masers achieved using the Australia Telescope Compact Array (ATCA). These observations were conducted toward 171 pointing centers where OH maser candidates were identified previously in the Southern Parkes Large-Area Survey in Hydroxyl toward the Galactic center region between Galactic longitudes of 355◦ and 5◦ and Galactic latitudes of −2° and +2°. We detect maser emission toward 162 target fields and suggest that six out of nine nondetections are due to intrinsic variability. Due to the superior spatial resolution of the follow-up ATCA observations, we have identified 356 OH maser sites in the 162 target fields with maser detections. Almost half (161 of 356) of these maser sites have been detected for the first time in these observations. After comparing the positions of these 356 maser sites to the literature, we find that 269 (76%) sites are associated with evolved stars (two of which are PNe), 31 (9%) are associated with star formation, and four are associated with supernova remnants; we were unable to determine the origin of the remaining 52 (15%) sites. Unlike the pilot region, the infrared colors of evolved star sites with symmetric maser profiles in the 1612 MHz transition do not show obvious differences compared with those of evolved star sites with asymmetric maser profiles.
Transformation et dialectique chez Marx
Authors: Jorland Gérard 
Published: November 2018

Cette étude tend à montrer que l’œuvre de Marx procède d’une intuition ontologique, à savoir que tout est transformation (Verwandlung). Il est alors possible de montrer que les trois tomes du Capital reviennent à une série articulée de transformations. Marx pense ces transformations en termes syllogistiques hégéliens. Cette formulation syllogistique permet de comprendre, premièrement, que la dernière de ces transformations, la transformation des valeurs en prix de production, soit restée incomplète bien que Marx en eût conscience ; deuxièmement, que la publication du Capital soit restée inachevée du vivant de Marx ; troisièmement, que le socialisme ait été un échec économique.