bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Segmented Multi‐Source Sediment Routing System on the Hangingwall Dipslope of the Xihu Depression, East China Sea Shelf Basin: Insights From Palaeogeomorphology, U–Pb Ages and Heavy Minerals
Authors: Zhou Ziqiang , Zhu Hongtao , Liu Qianghu , Qin Lanzhi 
Published: November 2024

ABSTRACTCoeval input systems in rift basins may interact with each other to form a segmented multi‐source sediment routing system. Importantly, its division into proximal zones, where a single source dominates, and interaction zones, where multiple sources mix, enables the interactions between input systems to be characterised. Here, we exploit this conceptual framework to revisit the middle Eocene–early Oligocene hangingwall dipslope of the Xihu depression in the East China Sea Shelf Basin, where extensive 3D seismic data, detrital zircon U–Pb ages and heavy mineral compositions are available. We first combined palaeogeomorphological and sedimentological features with age signatures to distinguish three areas: the northwestern area was identified for its proximity to the Haijiao uplift and invariably high proportions of Palaeoproterozoic ages (41%–54%); the southwestern area adjacent to the Yushan uplift was distinct for enriched Cretaceous‐aged zircons (36%) and the transition area in between was characterised by its remoteness to both uplifts, an embayed geometry and mixed age signatures that are not identical to any individual input. These spatial variations support the segmented framework for the multi‐source system, with the northwestern and southwestern areas representing two palaeo‐input systems and the transition area as their interaction zone. In this context, we then used mixture models to determine spatio‐temporal variations in the mixing proportions of the two palaeo‐input systems. The zircon‐based results indicate that the mixing proportion sustained from the middle to the late Eocene, during which the basin was in the late syn‐rift stage and marine environments. This is corroborated by heavy mineral composition that shows only minor changes. We interpret the roughly sustained mixing proportions as reflecting both the spatially uniform nature of broad subsidence and the strong tidal processes that ‘erased’ the effects of avulsions. In contrast, a clear provenance shift in both zircon ages and heavy minerals occurred from the late Eocene to the early Oligocene, coinciding with a transition to the tectonic inversion stage and a shift towards non‐marine environments. The provenance shift, together with the southward expansion of the axial drainage, likely represents the sedimentary response to the southward decreasing inversion magnitude of the Yuquan Event. In addition, we hypothesize that in the absence of strong tides, avulsions might have controlled the mixing proportion, particularly over short timescales. Ultimately, this study demonstrates the segmented multi‐source framework, if properly incorporated, can provide key insights into dipslope sedimentation.
Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients
Authors: Shi Yachen , Xu Min , Wang Feng , Zhang Xiaoxuan , Cheng Chao , Han Yan , Xi Guangjun , Mao Haixia , Deng Jingyu , Gao Qianqian , Ji Yi , Ma Xuemei , Li Mingyu , Fang Xiangming 
Published: November 2024

ABSTRACTAimsThe study attempted to determine the underlying role and regulation mechanism of 3β‐hydroxysterol‐Δ24 reductase (DHCR24) in the pathophysiology of cerebral small vessel disease‐associated cognitive impairment (CSVD‐CI). An RNA high‐throughput sequencing and independent verification were conducted to identify potential circRNAs becoming the upstream regulator.MethodsRNA sequencing was performed in whole‐blood samples in cohort 1 (10 CSVD‐CI and 8 CSVD with cognitively normal [CSVD‐CN] patients). The DHCR24 and candidate circRNAs were verified in an independent cohort 2 (45 CSVD‐CI participants and 37 CSVD‐CN ones). The study also analyzed comprehensive cognitive assessments, plasma molecular index, and brain structure imaging.ResultsThe expression of DHCR24 and has_circ_0015335 in whole‐blood samples of CSVD‐CI patients was significantly reduced compared to CSVD‐CN patients in RNA sequencing and independent verification. Furthermore, the levels of DHCR24 and has_circ_0015335 were significantly related to global cognitive impairment in CSVD‐CI patients. Meanwhile, DHCR24 could regulate the correlation between has_circ_0015335 expression and alterations in brain cortex in surface area, thickness, and volume in CSVD‐CI patients. Additionally, hsa_circ_0015335 interacted with DHCR24 for plasma 24(S)‐hydroxycholesterol levels among CSVD‐CI patients.ConclusionInteraction between DHCR24 and hsa_circ_0015335 cognitively impaired CSVD by affecting brain cholesterol metabolism and brain structural changes.
Red Tourists and National Identity in the Museum Commemorating Deng Xiaoping
Authors: Tang Yong , Tan Suya , Zhao Shuang , Cheng Weiyu 
Published: November 2024

ABSTRACTThis study aims to identify types of red tourists based on their travel motivations for visiting the museum commemorating Deng Xiaoping, with a focus on their experiential sense of national identity conceived by the two identified groups ahead of the centennial celebration of the Communist Party of China. Survey data collected from 349 mainland Chinese tourists revealed that red tourism in China is a complex cultural, social, and economic phenomenon, rather than merely an agent of political socialization, because the museum attracts red tourists who are interested not only in patriotic education and commemoration but also in leisure and recreation. Red visitors seem to be patriots who identify China as a multi‐ethnic country and a great nation, whereas red pilgrims are more likely to align with specific political ideologies, such as socialist road and core socialist values. The study enhances our understanding of the types of red tourists and their individual differences in travel motivations and national identity, suggesting curators evaluate the effectiveness of their marketing strategies and consider making minor changes to the exhibits for different types of visitors.
Data sharing and re‐use as a moral imperative in animal research
Authors: Bjerke Ingvild E. 
Published: November 2024

AbstractHere, I discuss data sharing and re‐use as a moral imperative for research that uses animals in neuroscience. I argue that we are ethically required to make sure that we gain as much knowledge as possible from the animals we use, and that doing so involves making sure that the data from our experiment makes it into the public record of knowledge. I suggest several ways in which journals, grant bodies and policymakers can contribute to making data sharing and re‐use mainstream practices.
Effects of cross‐linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta‐analysis of in vitro studies
Authors: Monici Silva Isabela , Barbosa Cecília de Brito , Cena Jéssica Alves de , Ribeiro Erick , Garcia Fernanda Cristina Pimentel , Stefani Cristine Miron , Dame‐Teixeira Naile 
Published: November 2024

AbstractA promising approach for managing root caries is the use of cross‐linking agents to stabilize collagen. However, despite testing various natural and synthetic agents in vitro, their efficacy remains uncertain. The aim of this review was to examine which cross‐linking agent performs better in reducing root caries lesion depth and the release of hydroxyproline, which is a marker of collagen degradation. Studies evaluating the impact of cross‐linking agents on dentin were included, while studies performed on enamel surface/cell cultures and studies evaluating collagenase inhibitors were excluded, among others. A comprehensive search covered eight databases, and study quality was assessed using the QUINN Tool for in vitro dental studies. Synthesis of the results was done using a Bayesian network meta‐analysis to compare agents. Fifty studies involving 31 cross‐linking agents were included for qualitative synthesis. The network meta‐analysis for lesion depth involved 284 samples across 36 comparisons and ranked cross‐linking agents in terms of their caries lesion depth‐reducing effect (from best to worst): naringin > quercetin > riboflavin > proanthocyanidins > hesperidin > glutaraldehyde > cranberry > grape seed extract > untreated controls. Only naringin, quercetin, proanthocyanidins, and glutaraldehyde showed statistically significant efficacy over untreated controls. Cranberry extract excelled in reducing hydroxyproline release, followed by proanthocyanidins. In conclusion, proanthocyanidins positively affected both outcomes, suggesting they are prime candidates for translational research. Clinical studies are now essential to evaluate their real‐world effectiveness against root caries. PROSPERO‐CRD42023404911.
Drivers of Data Contribution to an Electronic Citizen Science Platform for Anglers in Denmark
Authors: Gundelund Casper , Marcer Marco , Skov Christian 
Published: November 2024

ABSTRACTCitizen science platforms are an alternative to traditional survey methods for collecting data from recreational fisheries. However, to supplement data collection, challenges associated with these platforms must be addressed, such as lack of recruitment and sustained engagement. Some platforms distinguish between recruitment and data contribution in that participants might register on a platform, but only a subset starts contributing data, and even fewer continue to do so. To further understanding of drivers behind data contribution, we first assessed the willingness to share information, using response rates to optional questions asked during account registration, among three distinct groups of participants on an electronic citizen science platform for anglers: (i) registered and did not contribute data (registrants); (ii) registered and contributed data in a single year (contributors); and (iii) registered and contributed data in multiple years (sustained contributors). We next modeled demographic and fishery‐specific questions to determine specific drivers of data contribution and sustained contribution. Willingness to share information upon registration was lowest among registrants, intermediate among contributors, and highest among sustained contributors. The answer to the question “How important is angling as a hobby for you?” was the main driver in moving from registrant to contributor and from contributor to sustained contributor (i.e., participants who considered angling a more important hobby were more likely to be contributors and sustained contributors). Additionally, the probability of being a contributor declined over time, and angler residence (postal codes) was a driver of sustained contribution. Our findings indicated temporal and spatial instability in the participant base.
The Changing Geography of Innovation: Comparing Urban, Suburban and Rural Areas
Authors: Holl Adelheid , Martínez Catalina , Casado Clara 
Published: November 2024

ABSTRACTUsing novel geocoded patent data for Spain, we analyze the changing spatial pattern of innovative activity at the municipal level from 1995 to 2017 and find that patenting has become increasingly concentrated in urban areas, and more so for the most disruptive innovations. We also find that even though there was a convergence trend before the 2008 Great Recession between suburban and urban core locations, it has since vanished, and stark differences continue to persist. We test for path dependent dynamics along with different determinants of the changing spatial pattern of patenting. Our granular analysis unveils a more nuanced view of the geography of innovation for urban, suburban and rural areas and for different types of inventions according to their degree of radicalness.
Intensive grazing confounds the patterns of plant compositional change along a soil pH gradient, not an aridity gradient, in the Mongolian steppe
Authors: Ishii Naohiro I. , Nishimura Issei , Qi Yulan , Gantsetseg Batdelger , Kagami Maiko , Takimoto Gaku , Sasaki Takehiro 
Published: November 2024

AbstractAridity, edaphic variables and livestock grazing are major drivers of plant community composition across arid rangelands. Accumulated knowledge exists on the impact of each driver on community composition. Although previous studies have demonstrated changes in direct grazing impacts on ecosystem functions and community composition at different aridity levels, ranging from mesic to arid grasslands, whether a regional‐scale and continuous spatial pattern of plant compositional change along a gradient of aridity or edaphic variables is altered by grazing remains controversial. We compared the determinants and patterns of compositional changes with/without highly intensive grazing in the semi‐arid/arid regions of Mongolia. The compositional changes based on Bray–Curtis dissimilarity were investigated using generalized dissimilarity modeling, including geographic distance, aridity, soil pH and soil texture as independent variables. Aridity consistently had a significant impact on community composition, regardless of the region and presence/absence of grazing. However, a difference in response patterns was observed between the regions. The compositional change was steeper at the upper (drier) limit of aridity than at the lower limit in the arid region. This pattern indicates the vulnerability of plant communities to aridity shifts owing to future climate change, especially in the desert steppe of Mongolia, although the predictions of shifts in aridity are not accurate. In addition, regardless of the region, the effects of soil pH on the community composition were eliminated by the presence of grazing. Grazing may homogenize community composition by not reflecting the spatial heterogeneity of soil pH or nutrient availability via selective herbivory. Despite the potential indirect impacts of climate change on community composition via soil pH, the observations for only plant communities under intensive grazing might overlook regional biodiversity changes caused by global change drivers.
UNDERSTANDING THE GREAT RECESSION THROUGH THE BANKING SECTOR
Authors: Ogawa Toshiaki 
Published: November 2024

AbstractI develop a general equilibrium model to explore heterogeneous bank liquidity management. Smaller banks, driven by stronger precautionary motives, tend to accumulate capital and liquidity buffers, rendering them less susceptible to liquidity risk than larger banks. Whereas negative productivity shocks affect all banks' loans similarly, liquidity shocks result in lending responses that vary by bank size. Mapping the model to panel data, I argue that initially, liquidity shocks were the primary driver of the Great Recession, followed by negative demand shocks that accounted for approximately 60% of the recession's greatest fall in aggregate loans.
Diagnosis and management of mantle cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance
Authors: Barraclough Allison , Tang Catherine , Lasica Masa , Smyth Elizabeth , Cirillo Melita , Mutsando Howard , Cheah Chan Y. , Ku Matthew 
Published: November 2024

AbstractMantle cell lymphoma (MCL) is a clinically heterogeneous B‐cell neoplasm with unique clinicopathological features, accounting for 5% of all non‐Hodgkin lymphoma. Although for many chemoimmunotherapy can lead to durable remissions, those with poor baseline prognostic factors, namely blastoid morphology, TP53 aberrancy and Ki67 >30%, will have less durable responses to conventional therapies. With this in mind, clinical trials have focused on novel targeted therapies to improve outcomes. This review details the recent advances in the understanding of MCL biology and outlines the recommended diagnostic strategies and evidence‐based approaches to treatment.
Immunoglobulin A Antibodies: From Protection to Harmful Roles
Authors: Gleeson Patrick J. , Camara Niels O. S. , Launay Pierre , Lehuen Agnès , Monteiro Renato C. 
Published: November 2024

ABSTRACTImmunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a unique class of immunoglobulin due to its multiple molecular forms, and a defining difference between the two subclasses: IgA1 has a long hinge‐region that is heavily O‐glycosylated, whereas the IgA2 hinge‐region is shorter but resistant to bacterial proteases prevalent at mucosal sites. IgA is essential for immune homeostasis and education. Mucosal IgA plays a crucial role in maintaining the integrity of the mucosal barrier by immune exclusion of pathobionts while facilitating colonization with certain commensals; a large part of the gut microbiota is coated with IgA. In the circulation, monomeric IgA that has not been engaged by antigen plays a discrete role in dampening inflammatory responses. Protective and harmful roles of IgA have been studied over several decades, but a new understanding of the complex role of this immunoglobulin in health and disease has been provided by recent studies. Here, we discuss the physiological and pathological roles of IgA with a special focus on the gut, kidneys, and autoimmunity. We also discuss new IgA‐based therapeutic approaches.
Dental Caries and Extrinsic Black Tooth Stain in Children With Primary, Mixed and Permanent Dentitions: A Cross‐Sectional Study
Authors: Feng Jiangling , Yu Siyuan , Zhou Ni , Liu Juan , Ding Hui , Wu Yao , Wong Hai Ming 
Published: November 2024

ABSTRACTBackgroundDental caries and extrinsic black tooth stain (EBS) are prevalent among children, with current evidence suggesting a negative correlation between them. It is unclear whether the factors contributing to developing or preventing dental caries and EBS are connected or aligned.AimTo investigate the prevalence and associated factors of caries and EBS among children with primary, mixed and permanent dentitions.DesignThis was designed as a cross‐sectional study. Probability proportionate to size sampling and simple random sampling methods were used to recruit children aged 5, 9 and 12. Three calibrated paediatric dentists conducted intra‐oral examinations. Nutritional supplements, oral health–related behaviours and family background were collected. Bivariate analysis, negative binomial and binary logistic regression were performed.ResultsCaries and EBS prevalence were 83.7% and 4.7%, respectively. A decreasing trend in caries and an increasing trend in EBS prevalence were observed across three dentitions. Caries were associated with EBS, oral hygiene, vitamin intake, gender, food‐pocketing habits, toothbrushing duration, dental attendance and socioeconomic status. EBS was more likely to occur in caries‐free children (OR = 4.42, 95% CI 2.97,6.58, p < 0.001) and children without vitamin consumption (OR = 1.59, 95% CI 1.07, 2.36, p = 0.021).ConclusionThe occurrence of caries and EBS varied across different dentition stages. Their risk and protective factors were not significantly aligned.
Bipolar HiPIMS kick‐pulse for high hardness in high‐entropy boride thin films
Authors: McIlwaine Nathaniel S. , Rios Nestor O. Marquez , Zurek Eva , Brenner Donald W. , Fahrenholtz William G. , Curtarolo Stefano , Wolfe Douglas E. , Maria Jon‐Paul 
Published: November 2024

AbstractWe report a microhardness indentation study for multicomponent refractory metal boride thin films that belong to the family of high‐entropy ceramics exhibiting superior hardness and high temperature properties. We focus on the nominally equimolar composition (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)B2, which we refer to as HEB3, on c‐plane sapphire substrates. Thin films are prepared using bipolar high power impulse magnetron sputtering (HiPIMS), where the positive kick pulse is optimized to produce films with high density, high crystallinity, and a microstructure that is isometric in nature as revealed by cross‐sectional fracture surface imaging, X‐ray diffraction, and X‐ray reflectometry. Low‐load Knoop indentation is used to measure microhardness. We find strong trends linking kick‐pulse magnitude, microstructure uniformity, high density, and Knoop hardness. Optimized conditions can produce films with low‐load Knoop hardness exceeding 30 GPa. To validate these trends, we present a rigorous indent characterization campaign and discussion considering possible artifacts from roughness, thickness, and indent loading. The key finding of our study is the ability of engineering bombardment by using a low duty‐cycle pulsed plasma to manipulate crystal structure without sacrificing crystallinity, and in turn boost material hardness.
Short‐range order and topology of Te‐rich amorphous Ge–Sb–Te alloys
Authors: Pethes I. , Piarristeguy A. , Pradel A. , Escalier R. , Micoulaut M. , Michalik S. , Darpentigny J. , Zitolo A. , Jóvári P. 
Published: November 2024

AbstractThe structure of evaporated amorphous GexSbxTe100−2x (x = 6, 9, 13) alloys was investigated by neutron diffraction, X‐ray diffraction, and extended X‐ray absorption spectroscopy at the Ge, Sb, and Te K‐edges. Large‐scale structural models were generated by fitting the experimental datasets (five for each composition) simultaneously in the framework of the reverse Monte Carlo simulation technique. It was found that the alloys are chemically ordered (Ge and Sb have predominantly Te neighbors) and within the experimental uncertainty, each component satisfies the 8 – N rule. A comparison with the pair correlation functions of melt‐quenched Ge20Te80 revealed that the first minimum of gTeTe(r) is shallower in the ternary alloys than in Ge20Te80. On the other hand, the separation of the first and second coordination environments of Ge atoms is stronger in the Ge–Sb–Te alloys investigated.
Er3+–Yb3+ codoped oxyfluoride germanate glass ceramics containing SrF2 nanocrystals for 1.5 µm optical amplification
Authors: Li Siqiang , Zhang Xizhen , Song Linke , Zhang Yanqiu , Gao Duan , Zhang Sujuan , Pan Xiuyu , Zhang Yuhang , Chen Baojiu 
Published: November 2024

AbstractEr3+–Yb3+ codoped transparent oxyfluoride germanate glass ceramics (GCs) containing SrF2 nanocrystals (NCs) have been prepared by melt quenching method. We have measured absorption, photoluminescence (PL), and PL decay. The PL spectra excited at 378 nm and 980 nm for 1.53 µm near‐infrared (NIR) and visible emission have been investigated. By using Judd–Ofelt (JO) theory, optical transition parameters have been calculated. Thanks to low phonon energy SrF2 NCs and high fluorine oxyfluoride glass matrix, strong 1.53 µm emission with large measured lifetime (τmeas) are observed. After SrF2 NCs formed, the intensity parameter Ω2 becomes smaller for GC samples, the PL intensity and full width at half maximum increase. Absorption cross section (σa) and emission cross section (σe) at 1.5 µm have been calculated by McCumber theory. The luminescence efficiency (η), effective linewidth (Δλeff), gain bandwidth (σeΔλeff), and figure of merit (σeτm) have been evaluated. The results show excellent optical amplification performance.