bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumption within a soft total institution: Discursive inculcation in the Tablighi Jamaat
Authors: Rauf Ateeq A. , Prasad Ajnesh , Razzaque Mohammed A. 
Published: November 2018

AbstractErving Goffman’s concept of total institutions has been seldom explored in terms of how it restricts or promotes consumption practices. In an effort to redress the lacuna in the extant literature, this article draws on the findings of an ethnographic study of the Tablighi Jamaat, an orthodox religious organization originating in South Asia, whose participants undergo discursive inculcation in an environment that may be characterized as a soft total institution. We explore how consumption in such an environment entails processes of traditionalization under (late) modernity. Our findings show that consumption in a soft total institution requires subjects to monitor their own behavior discursively in order to attain certain intended, spiritual objectives. The study has implications for how consumption can be a means by which to either meet or inhibit life goals. In terms of theoretical contribution, this article begins to demarcate the boundary conditions between Goffman’s total institution and, what we are terming here, a soft total institution. Finally, we further Goffman’s original thesis by describing some of the subjects’ thoughts and experiences of their daily lives after their inculcation within the institutionalized setting.
Religious or secular? School type matters as a moderator between media exposure and children’s materialism
Authors: Dávila Juan Francisco , Casabayó Mònica , Rayburn Steven W. 
Published: November 2018

AbstractThis article examines the influence of media exposure, specifically TV and the Internet, on materialism in school‐aged children considering the moderating effects of school type, religious, or secular. Data were collected from a sample of 492 children in four schools and was analyzed using correlation tests, PROCESS moderation tests, and structural equation modeling. Results expose the moderating effect of school type. Cultural broadening theory illuminates the reasons behind these effects. In addition, participation in social networks is revealed as a partial mediator in the relationship between the Internet exposure and materialism. Implications for parents and educators hint that, even if children are “isolated” from the overwhelming materialistic messages in media, a time will come when they'll be exposed to these messages (in adolescence or earlier). Discussing the pros and cons of advertising, making children aware of companies’ tactics and explaining the dangers of a life focused on possessions may help schools and parents prevent the development of materialism in children.
Do religion and religiosity affect consumers’ intentions to adopt pro‐environmental behaviours?
Authors: Hwang Hyesun 
Published: November 2018

AbstractThis study attempts to explore the relationship between religion and pro‐environmental consumption in terms of the consumers’ willingness to pay premium prices and additional taxes and lower their living standards in South Korea. Data were obtained from the 2014 Korean General Social Survey. The survey participants were initially classified into religious and non‐religious groups; the religious group was further classified into the following two groups: community‐based (Protestants and Catholics) and individual‐based (Buddhists) religious groups. The differences between the religious groups in their intentions to make pro‐environmental choices were verified. First, religious consumers showed a more positive attitude towards paying premium prices and lowering their living standards than non‐religious consumers. Second, the community‐based religious group, a group characterized by low‐internal and high‐external religiosity, showed a greater intention to adopt pro‐environmental behaviours, whereas opposite results were obtained for the individual‐based religious group. The results showed that community‐based religious consumers exhibited higher intentions when actively interrelated with a religious community, even though they may have lower internal religiosity. This study provides meaningful implications for the relationship between religion and consumer behaviour, an important factor in shaping intrinsic consumer values and constructing a subculture and community extrinsically.
Preconditioning strategies for improving the survival rate and paracrine ability of mesenchymal stem cells in acute kidney injury
Authors: Zhao Lingfei , Hu Chenxia , Zhang Ping , Jiang Hua , Chen Jianghua 
Published: November 2018

AbstractAcute kidney injury (AKI) is a common, severe emergency case in clinics, with high incidence, significant mortality and increased costs. Despite development in the understanding of its pathophysiology, the therapeutic choices are still confined to dialysis and renal transplantation. Considering their antiapoptotic, immunomodulatory, antioxidative and pro‐angiogenic effects, mesenchymal stem cells (MSCs) may be a promising candidate for AKI management. Based on these findings, some clinical trials have been performed, but the results are contradictory (NCT00733876, NCT01602328). The low engraftment, poor survival rate, impaired paracrine ability and delayed administration of MSCs are the four main reasons for the limited clinical efficacy. Investigators have developed a series of preconditioning strategies to improve MSC survival rates and paracrine ability. In this review, by summarizing these encouraging studies, we intend to provide a comprehensive understanding of various preconditioning strategies on AKI therapy and improve the prognosis of AKI patients by regenerative medicine.
O‐GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
Authors: Wu Nan , Jiang Mingzuo , Han Yuying , Liu Haiming , Chu Yi , Liu Hao , Cao Jiayi , Hou Qiuqiu , Zhao Yu , Xu Bing , Xie Xin 
Published: November 2018

AbstractThe RNA helicase p68 (DDX5), a key player in RNA metabolism, belongs to the DEAD box family and is involved in the development of colorectal cancer. Here, we found both DDX5 and O‐GlcNAcylation are up‐regulated in colorectal cancer. In addition, DDX5 protein level is significantly positively correlated with the expression of O‐GlcNAcylation. Although it was known DDX5 protein could be regulated by post‐translational modification (PTM), how O‐GlcNAcylation modification regulated of DDX5 remains unclear. Here we show that DDX5 interacts directly with OGT in the SW480 cell line, which is the only known enzyme that catalyses O‐GlcNAcylation in humans. Meanwhile, O‐GlcNAcylation could promote DDX5 protein stability. The OGT‐DDX5 axis affects colorectal cancer progression mainly by regulating activation of the AKT/mTOR signalling pathway. Taken together, these results indicated that OGT‐mediated O‐GlcNAcylation stabilizes DDX5, promoting activation of the AKT/mTOR signalling pathway, thus accelerating colorectal cancer progression. This study not only reveals the novel functional of O‐GlcNAcylation in regulating DDX5, but also reveals the carcinogenic effect of the OGT‐DDX5 axis in colorectal cancer.
Disabled‐1 is down‐regulated in clinical breast cancer and regulates cell apoptosis through NF‐κB/Bcl‐2/caspase‐9
Authors: Cao Rang‐Juan , Li Kai , Xing Wan‐Ying , Du Shuang , Li Qiang , Zhu Xiao‐Juan , Cui Shu‐Sen 
Published: November 2018

AbstractDisabled‐1 (Dab1) is best known as an adaptor protein regulating neuron migration and lamination during development. However, the exact function of Dab1 in breast cancer is unknown. In this study, we examined the expression of Dab1 in 38 breast cancer paraffin sections, as well as 60 paired frozen breast cancer and their adjacent tissues. Our results showed that Dab1 was reduced in breast cancer, and its compromised expression correlated with triple negative breast cancer phenotype, poor differentiation, as well as lymph node metastasis. Functional analysis in breast cancer cell lines demonstrated that Dab1 promoted cell apoptosis, which, at least partially, depended on its regulation of NF‐κB/Bcl‐2/caspase‐9 pathway. Our study strongly suggests that Dab1 may be a potential tumour suppressor gene in breast cancer.
Exosomes from mesenchymal stem cells expressing miR‐125b inhibit neointimal hyperplasia via myosin IE
Authors: Wang Dongqing , Gao Bin , Yue Jianing , Liu Fei , Liu Yifan , Fu Weiguo , Si Yi 
Published: November 2018

AbstractIntercellular communication between mesenchymal stem cells (MSCs) and their target cells in the perivascular environment is modulated by exosomes derived from MSCs. However, the potential role of exosome‐mediated microRNA transfer in neointimal hyperplasia remains to be investigated. To evaluate the effects of MSC‐derived exosomes (MSC‐Exo) on neointimal hyperplasia, their effects upon vascular smooth muscle cell (VSMC) growth in vitro and neointimal hyperplasia in vivo were assessed in a model of balloon‐induced vascular injury. Our results showed that MSC‐Exo were internalised by VSMCs and inhibited proliferation and migration in vitro. Further analysis revealed that miR‐125b was enriched in MSC‐Exo, and repressed the expression of myosin 1E (Myo1e) by targeting its 3ʹ untranslated region. Additionally, MSC‐Exo and exosomally transferred miR‐125b repressed Myo1e expression and suppressed VSMC proliferation and migration and neointimal hyperplasia in vivo. In summary, our findings revealed that MSC‐Exo can transfer miR‐125b to VSMCs and inhibit VSMC proliferation and migration in vitro and neointimal hyperplasia in vivo by repressing Myo1e, indicating that miR‐125b may be a therapeutic target in the treatment of vascular diseases.
Up‐regulation of SPINT2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion
Authors: Roversi Fernanda Marconi , Cury Nathalia Moreno , Lopes Matheus Rodrigues , Ferro Karla Priscila , Machado‐Neto João Agostinho , Alvarez Marisa Claudia , dos Santos Gabriela Pereira , Giardini Rosa Renata , Longhini Ana Leda , Duarte Adriana da Silva Santos , Pericole Fernando Vieira , Favaro Patricia , Yunes José Andres , Saad Sara Teresinha Olalla 
Published: November 2018

AbstractThe role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease inhibitor kunitz‐type2 (SPINT2/HAI‐2), an inhibitor of hepatocyte growth factor (HGF) activation, is significantly lower in BMMSC from myelodysplastic syndromes (MDS) patients compared to healthy donors (HD). Thus, to investigate whether this loss of expression was due to SPINT2/HAI‐2 methylation, BMMSC from MDS and de novo acute myeloid leukaemia (de novo AML) patients were treated with 5‐Azacitidine (Aza), a DNA methyltransferase inhibitor. In MDS‐ and de novo AML‐BMMSC, Aza treatment resulted in a pronounced SPINT2/HAI‐2 levels up‐regulation. Moreover, Aza treatment of HD‐BMMSC did not improve SPINT2/HAI‐2 levels. To understand the role of SPINT2/HAI‐2 down‐regulation in BMMSC physiology, SPINT2/HAI‐2 expression was inhibited by lentivirus. SPINT2 underexpression resulted in an increased production of HGF by HS‐5 stromal cells and improved survival of CD34+ de novo AML cells. We also observed an increased adhesion of de novo AML hematopoietic cells to SPINT2/HAI‐2 silenced cells. Interestingly, BMMSC isolated from MDS and de novo AML patients had increased expression of the integrins CD49b, CD49d, and CD49e. Thus, SPINT2/HAI‐2 may contribute to functional and morphological abnormalities of the microenvironment niche and to stem/progenitor cancer cell progression. Hence, down‐regulation in SPINT2/HAI‐2 gene expression, due to methylation in MDS‐BMMSC and de novo AML‐BMMSC, provides novel insights into the pathogenic role of the leukemic bone marrow microenvironment.
Designing and evaluating functional laboratory information system requirements integrated to hospital information systems
Authors: Farzandipour Mehrdad , Meidani Zahra , Sadeqi Jabali Monireh , Dehghan Bnadaki Razieh 
Published: November 2018

AbstractRationale, aims, and objectivesLaboratory information sub‐systems play an important role in diagnosis and treatment of patients. This study aimed to determine functional requirements of users and assess the existence of these requirements in the laboratory information system.MethodThis descriptive cross‐sectional study was conducted in 2016 in two phases. The first phase was done through three stages. First, based on an unsystematic review of related literature, an outline of functional laboratory information system requirements was identified. In the second stage, these requirements were identified in group meetings in the form of a semi‐structured questionnaire and given to experts. Then, modified Delphi technique was used to reach agreement on each item. Then, based on experts' comments, the final version of the questionnaire was presented including 61 closed‐ended items using Likert scale and an open‐ended item. It was surveyed by 50 experts using Delphi technique. Responses were scored, and the requirements whose mean final score was 3 and above were finally confirmed. In the second phase, based on the confirmed requirements, a checklist comprising 68 requirements was prepared and adopted hospital information systems were evaluated through researcher observation. Data were analysed using descriptive statistics.ResultsThe final list of functional laboratory information system requirements was prepared with 68 items. The results of the evaluation revealed that confirmed requirements existed in 58.8% of hospital information systems.ConclusionLaboratory information system requirements were designed with 68 items. Evaluation results showed that the systems were moderate in terms of compliance with the requirements.
The impacts of vacuum microwave drying on osmosis dehydration of tilapia fillets
Authors: Wang Qi , Liu Bing , Cao Jun , Li Chuan , Duan Zhenhua 
Published: November 2018

AbstractHot‐air (HAD), vacuum microwave (VMD), osmosis microwave (O‐MD), and osmosis vacuum microwave (O‐VMD) drying were applied to investigate the effects of osmosis dehydration and vacuum microwave on the quality and structure of tilapia fillets. Shrinkage ratio, rehydration rate, color, hardness, elasticity, microstructure, per‐unit energy consumption, and main nutritional components of tilapia fillets were compared over the four drying methods. Moisture content was quickly decreased by osmotic pretreatment. Fillets were dehydrated in a short time via microwave conditions (3 min by O‐MD; 11 min by O‐VMD). A vacuum environment promoted the formation of porous structures inside the fish fillets. As for nutrient composition, shrinkage rate, rehydration rate, hardness and elasticity, O‐VMD fillets and VMD fillets had similar performance. The composite drying method of O‐VMD improved the quality of the product and had comparatively better in terms of microstructure, per‐unit energy consumption (24.04 kJ/g) and color change (13.8). Thus, tilapia fillets produced by O‐VMD were of higher quality. Meanwhile, this study provided a reference for further research.Practical applicationsThe purpose of dehydration is to decrease the moisture content to a low level at which microbial spoilage and quality deterioration are minimized. Drying is a traditional dehydration method in fish processing, able to deactivate the enzymes and remove the moisture to inhibit the growth of microorganisms. Vacuum microwave drying (VMD) uses microwave heating to dry the material under a vacuum environment with a low boiling point, a new technology in modern food processing that was developed to improve the quality of products. Few published studies have applied osmosis vacuum microwave drying to fish processing. Therefore, the aim of this work was to study the effects of vacuum and osmosis pretreatment on fillets drying process. Provided data can be applied for comparing the effects of different drying methods on tilapia fillet quality.
Identification and functional study of three nAChR regulators, ubiquilin‐1, PICK1, and CRELD2, in Locusta migratoria manilensis dorsal unpaired median neurons
Authors: Yu Na , Wang Xin , Bao Haibo , Liu Zewen 
Published: November 2018

AbstractInsect nicotinic acetylcholine receptors (nAChRs) are not only important neurotransmitter receptors but also effective insecticide targets. The regulation of nAChRs has been mainly studied in vertebrates, especially in mammals. Here, two types of nAChRs were found present in the locust Locusta migratoria manilensis dorsal unpaired median (DUM) neurons, α‐bungarotoxin (α‐Bgt)‐sensitive nAChRs and α‐Bgt‐resistant nAChRs, responding to acetylcholine (ACh) at different concentrations. The homologs to three mammalian nAChR regulators, ubiquilin‐1, CRELD2 (cysteine‐rich with EFG‐like domain 2), and PICK1 (protein interacting with PRKCA 1), were characterized in L. migratoria, and their functions on regulating native nAChRs were investigated via RNAi followed by membrane potential measurement with DiBAC4(3) and agonist‐evoked macroscopic current recording in cultured L. migratoria DUM neurons. Ubiquilin‐1 and PICK1 negatively regulated nAChRs because silencing of ubiquilin‐1 and PICK1 both resulted in increased membrane potential and increased inward currents in DUM neurons, while CRELD2 positively regulated nAChRs as decreased membrane potential and inward currents were observed in DUM neurons. In addition, ubiquilin‐1 regulated both α‐Bgt‐sensitive and α‐Bgt‐resistant types of nAChRs whereas PICK1 and CRELD2 regulated only the α‐Bgt‐resistant nAChRs. The present study broadened our understanding on the regulation of insect nAChRs and will benefit pest management given the important role of nAChRs in insect neurons and insecticide science.Open science badgesThis article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/.
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Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin‐converting enzyme inhibitors – a nationwide registry‐based cohort study
Authors: Rasmussen Eva Rye , Pottegård Anton , Bygum Anette , von Buchwald Christian , Homøe Preben , Hallas Jesper 
Published: November 2018

AbstractBackgroundIt has long been suggested that angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (AT2s) have some degree of ‘cross‐reactivity' in causing angioedema. Therefore, caution has been advised when switching patients with ACEi‐related angioedema to an AT2.ObjectivesTo clarify whether AT2s can be used safely in patients with a history of angioedema during ACEi treatment and to estimate the incidence rate of angioedema in patients subsequently treated with other antihypertensive drugs (beta‐adrenergic blockers, calcium channel blockers, thiazides and analogues) or no antihypertensives.MethodsThis is a nationwide retrospective registry‐based cohort study of the Danish population during the period 1994 to 2016, and it uses Danish health registries. Propensity score adjusted and conventional proportional hazards regression models have been employed.ResultsA total of 1 106 024 ACEi users were identified. In total, 5 507 (0.5%) of these patients had experienced angioedema during ACEi treatment and were included in the study. The highest risk of angioedema recurrence was associated with continued ACEi use at an adjusted hazard ratio of 1.45 (95% CI, 1.19 to 1.78). An inverse association was found between AT2s and angioedema (adjusted hazard ratio, 0.39; 95% CI, 0.30 to 0.51) compared with other antihypertensives (adjusted hazard ratios, 0.77 to 0.97).ConclusionsCompared with other antihypertensive drugs, AT2s do not increase the incidence of angioedema in patients with previous ACEi‐related angioedema.
Association Between Early Implant Failure and Prosthodontic Characteristics
Authors: Carr Alan B. , Sinha Nikita , Lohse Christine M. , Muller Olivia M. , Salinas Thomas J. 
Published: November 2018

AbstractPurposeTo identify associations between early implant failure and prosthodontic characteristics that could be used to guide subsequent continuous quality improvement efforts of patient care.Materials and MethodsAn implant‐level analysis was performed in which data were abstracted from a prospective clinical database of all adult patients treated with implants and followed up from January 2000 through December 2014 at the Department of Dental Specialties at Mayo Clinic in Rochester, Minnesota. These data were used to determine time to implant failure. Associations between prosthodontic characteristics and early implant failure were evaluated with Cox proportional hazards regression models and summarized with hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsAmong 8762 implants in 2787 patients, 395 (4.5%) failed within the first year of placement at a mean (SD) of 127 (97) days (range, 2‐364 days). Univariable analysis showed no associations between early implant failure and use of a cover screw, prosthesis, or definitive or provisional prosthesis at implant placement. Three of 25 single crowns failed, and use of a single crown was significantly associated with early implant failure (HR, 3.94; 95% CI, 1.08‐14.35; P = 0.04). This study identified no significant associations between prosthodontic characteristics identified after implant placement and early implant failure.ConclusionsUse of a prosthesis at implant placement, use of a definitive or provisional prosthesis, and early mechanical complications were not associated with increased risk of early implant failure. Quality improvement efforts should focus on aspects of decision making that aim to decrease surgical complications.