bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Achyranthes aspera Extracts on the Survival and Midgut Histo-architecture of Aedes aegypti L. Early IV Instars
Authors: Sharma Aarti , Kumar Sarita , Tripathi Pushplata 
Published: October 2018

Background:

Aedes aegypti L.; one of the most important insect vectors in the world; transmits several diseases of concern; Zika, yellow fever, Chikungunya, dengue and dengue haemorrhagic fever. Despite multifarious problems on humans, non-targets and environment; caused by synthetic chemical insecticides; these are still the prime and preferred control measures against dengue vector. Alternative control strategies using eco-friendly and bio-degradable plant products are being explored.

Objective:
The present study investigates the toxic potential of the hexane extract of the leaf and stem of Achyranthes aspera against Ae. aegypti.

Methods:
The larvicidal potential of extracts was evaluated against dengue larvae as per WHO protocol. Subsequent concentration and time-dependent studies assessed their effects on the larval midgut histo-architecture using microtomy techniques.

Results:
Larvicidal bioassays with A. aspera extracts revealed their appreciable larvicidal potential. Hexane extract of the leaf resulted in respective LC30, LC50 and LC90 values of 67, 83 and 140 ppm while exposure to hexane extract of the stem showed respective values of 55, 68 and 115 ppm. Extract-exposed larvae at various lethal levels exhibited significant damage, shrinkage, distortion and vacuolization of gut tissues and peritrophic membrane. The disintegration of epithelial cells and cytoplasmic organelles evidenced stomach poison potential of the extracts. The extent of toxicity and damage was concentration and time-dependent; the stem extract imparted more deleterious effects as compared to the leaf extract.

Conclusion:
Present findings suggest the utilization of A. aspera as an alternate control strategy against Ae. aegypti; though further studies against non-targets are needed to ascertain its use in the fields.
Association Between Health-Related Quality of Life and Physical Functioning in Antiretroviral-Naive HIV-Infected Patients
Authors: Lédo Ana Paula , Rodriguez-Prieto Indira , Lins Liliane , Neto Mansueto Gomes , Brites Carlos 
Published: October 2018

Background:
Poor functional status can significantly affect Health-Related Quality of Life (HRQoL) of HIV patients. However, there is scarce information on the functional profile of such patients before starting antiretroviral therapy (ART).

Objective:
To estimate the association between health-related quality of life and physical functioning in Antiretroviral-Naive HIV-infected patients.

Methods:
We conducted a cross-sectional study with HIV-infected patients older than 18 years, and naïve to antiretroviral therapy. The patients were evaluated for functional profile by pulmonary function (forced vital capacity, forced expiratory volume at one second, and Tiffeneau index), handgrip strength, and six-minute walk test in a cross-sectional study. HRQoL was evaluated by the 36-Item Short-Form Health Survey and its Physical (PCS) and Mental (MCS) Component Summaries. Multiple linear regression analyses were used to evaluate the association of predictor variables with PCS and MCS scores.

Results:
We found lower HRQoL among females patients, with far below average impairment of mental health component. Both male and female patients presented lower 6MWD function test values. Patients with dynapenia were older than patients without it, presented lower PCS mean score, lower family income, poor 6 MWD function test, lower FVC, and lower FEV1 t. Multivariable logistic regression analyses showed that Grip Strength, age and family income were predictor variables for Physical component of HRQoL. Female gender and smoking habit were predictive for the mental component of HRQoL.

Conclusion:
HRQoL in HIV, drug-naïve patients is predicted by level of dynapenia, smoking, income and gender. Therefore, lifestyle changes and active exercising can help to improve HRQoL in such patients.
PSYCHOPHYSIOLOGICAL PREDICTORS OF HUMAN AND SYSTEM INTEGRATION ON MODERN NAVAL SHIPS OF THE RUSSIAN NAVY
Authors: Bilyi A. M. , Vasilkov A. M. 
Published: October 2018

The article demonstrates that demands of modern ergonomics in man-machine combination mean scientific-based «machine» requirements as well as man-requirements since they limit reliability of whole system. Comparative study was held among operators (learning network), persons affected by asthenoneurotic syndrome, survey was carried out in private company. It has been discovered that besides usual procedure of job specification and recruiting it is necessary to assess dominating type of behavior, perception and information processing. Compatibility of the type with work requirements affects the effectiveness of mastering of profession and burnout and occupational health. This theory was tested in private company when developing quality management system using Expert system of human comprehensive analysis. Observation was held within six years. The result is that quantity of days because of illness reduced in 2,9 times. It can be said that this parameter is the objective index of human integration and properly developed quality management system in a company. The quality management system worked out in the base of Expert system of human comprehensive analysis allows to reduce burnout of personnel and keep up their occupational health. Basing on survey results the main profiles of operator performance were analyzed taking into account dominating type of behavior, perception and information processing. Thus psychophysiological predictors for potential naval operators were identified. This objective is relevant in naval construction of Russia.
KORELASI ANTARA ASUPAN VITAMIN D DENGAN KADAR 25(OH)D SERUM PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK PEREMPUAN DEWASA
Authors: Suzan Raihanah 
Published: October 2018

ABSTRACT

Objective:
the aim of the study is to investigate the correlation between vitamin D intake and serum 25(OH)D concentration of adult woman SLE patients.
Methods:
A cross-sectional study was conducted in 36 adult woman patients with SLE from Rheumatology Clinic of the Departemen of Internal Medicine Dr. Cipto Mangunkusumo hospital. Data collection included age, SLE classification, drugs, skin type, use of sunscreen, part of the body covered by clothes, length of sun exposure, body mass index (BMI), vitamin D intake, and serum 25(OH)D concentration.
Results:
Most of the subjects (41.7%) aged 36–45 years old, classified as mild SLE (52.8%), always used sunscreen (63.9%), skin type IV (69.4%), wearing clothes that covered all or almost of the body (69.4%), and not exposed or had sun exposure less than 30 minute (77.8%). All subjects used corticosteroid. Based on BMI half of the subjects had normal body weight, Based on AKG 2012 most (55.6%) had adequate vitamin D intakes, and 28 subjects (77.8%) were in vitamin D-deficient (serum 25(OH)D concentration <50 nmol/L). There were moderate positive correlation between vitamin D intake and serum 25(OH)D concentration in subjects (r = 0.52; P <0.01).
Conclusion:
There were moderate positive correlation between vitamin D intake and serum 25(OH)D concentration of adult woman SLE patients (r = 0.52; P <0.01).
Key Words: Vitamin D; SLE; vitamin D intake; serum 25(OH)D concentration.

ABSTRAK

Tujuan:
Tujuan penelitian ini adalah mengetahui korelasi antara asupan vitamin D dengan kadar 25(OH)Dserum pada pasien lupus eritematosus sistemik perempuan usia dewasa.
Metode:
Penelitian ini merupakan penelitian potong lintang pada 36 pasien SLE perempuan dewasa dari Poliklinik Reumatologi di RS Dr. Cipto Mangunkusumo. Pengambilan data subyek meliputi usia, klasifikasi penyakit SLE, obat-obatan yang digunakan, tipe kulit, penggunaan tabir surya, bagian tubuh yang tertutup pakaian, lama terpajan sinar matahari, indeks massa tubuh (IMT), asupan vitamin D, dan kadar 25(OH)D serum.

Hasil:
Sebagian besar (41,7%) subyek berusia antara 36–45 tahun, tergolong klasifikasi SLE ringan (52,8%), selalu menggunakan tabir surya (63,9%), tipe kulit IV (69,4%), dan memakai pakaian yang menutupi seluruh/sebagian besar tubuh (69,4%), serta tidak terpajan dan terpajan sinar matahari <30 menit (77,8%). Semua subyek menggunakan kortikosteroid. Separuh subyek memiliki berat badan normal berdasarkan IMT, sebagian besar (55,6%) subyek mempunyai asupan vitamin D cukup berdasarkan AKG 2012, dan 28 subyek (77,8%) menderita defisiensi vitamin D ( kadar 25(OH)D serum <50 nmol/L). Didapatkan korelasi positif yang sedang antara asupan vitamin D dengan kadar 25(OH)D serum pada subyek penelitian (r = 0,52; P <0,01).
Kesimpulan:
Terdapat korelasi positif yang sedang antara asupan vitamin D dengan kadar 25(OH)D serum pada pasien SLE perempuan dewasa (r = 0,52; P <0,01).
Kata Kunci: Vitamin D; SLE; asupan vitamin D; kadar 25(OH)D serum.
MODELOS DE FORMAÇÃO DOCENTE EM PROJETOS CURRICULARES INOVADORES: REFLEXÕES A PARTIR DE UMA EXPERIÊNCIA FORMATIVA
Authors: Keller-Franco Elize 
Published: October 2018

No atual momento, quando se tornam prementes as mudanças nos programas que formam professores, o presente artigo traz para reflexão a discussão sobre os modelos de formação que orientam as propostas curriculares nos Cursos de Licenciaturas a partir da análise de uma experiência curricular com características de inovação desenvolvida na Universidade Federal do Paraná-Setor Litoral. Trata-se de uma pesquisa de abordagem qualitativa tendo como apoio a análise documental. Autores como Santos (2007), García (1999), Ávila (2008), Diniz-Pereira (2007) e Tardif (2011) deram suporte à construção do marco teórico conceitual com base nos modelos de formação propostos em seus estudos, a exemplo das orientações de cunho instrumental-tecnicista, epistemologia da prática e sociopolítica. Conclui-se que a experiência analisada se encaminha para um modelo crítico de formação que favorece a mudança em um conjunto de aspectos que se mostram vitais para uma revisão em cursos que prepararam os profissionais para a docência tais como: unidade entre teoria e prática na construção do conhecimento; integração entre universidade e escolas da educação básica num sentido de fortalecimento mútuo; articulação dos saberes em uma perspectiva de ruptura epistemológica que leva em consideração as experiências de vida de cada aluno e a constituição de novos espaços de aprendizagem para além dos muros da universidade, dentre outros.
Dorothy Hodgkin e seus estudos cristalográficos sobre a estrutura da penicilina
Authors: Prado Letícia Do 
Published: October 2018

ResumoDorothy Crowfoot Hodgkin formou-se em química pela Somerville Oxford, doutorou-se em Cambridge e liderou o grupo de pesquisa que decifrou a estrutura molecular de várias moléculas biológicas complexas como: a penicilina, a vitamina B12 e a insulina. Seu nome não foi tão ovacionado quanto o de outros ganhadores do Prêmio Nobel já que seu método de trabalho, a cristalografia de raio X para a análise de moléculas complexas era ainda pioneiro e pouco disseminado entre os laboratórios da época. Foi a busca de soluções exatas para problemas difíceis que motivaram Dorothy a superar tempos de guerra, contratempos experimentais, demandas do casamento, da maternidade e a dor física persistente, para se tornar uma das maiores cientistas do século. Neste trabalho apresentaremos brevemente a vida de Dorothy, sua infância distante dos pais e rica em experiências culturais, sua juventude, as dificuldades que precederam sua entrada na Universidade e sua vida como pesquisadora, e mais especificamente, falaremos sobre sua colaboração para a solução da estrutura molecular da penicilina no cenário da Segunda Guerra Mundial. Nosso objetivo é apresentar ao leitor o trabalho de Dorothy ancorados em suas publicações originais e suas biografias, de maneira a contribuir com a disseminação da história das mulheres na ciência. Palavras-chave: Dorothy Crowfoot Hodgkin; Penicilina; Mulheres na Ciência.AbstractDorothy Crowfoot Hodgkin graduated in chemistry from Somerville Oxford, doctorate from Cambridge and led the research group that deciphered the molecular structure of several complex biological molecules such as penicillin, vitamin B12 and insulin. Her name was not as ovation as that of other Nobel Prize winners since their method of working, X-ray crystallography for the analysis of complex molecules was still pioneering and little disseminated among laboratories of the time. It was the search for exact solutions to difficult problems that motivated Dorothy to overcome wartime, experimental setbacks, marriage demands, maternity, and persistent physical pain to become one of the greatest scientists of the century. In this work we will briefly present the life of Dorothy, her childhood far from her parents and rich in cultural experiences, her youth and the difficulties that preceded her entrance into the University and her life as a researcher, and more specifically, we will talk about her collaboration for the solution of molecular structure of penicillin in the scene of World War II. Our goal is to present the Doroty works, anchored in her original published and her biographies in order to contribute with the dissemination of history of women in science.Keywords: Dorothy Crowfoot Hodgkin; Penicillin; Women in Science.
El trabajo de alimentar: proceso alimentario entre trabajadores y trabajadoras agrícolas migrantes en Miguel Alemán, Sonora
Authors: Arellano Gálvez María del Carmen , Alvarez Gordillo Guadalupe del Carmen , Tuñón Pablos Esperanza , Huicochea Gómez Laura 
Published: October 2018

El artículo analiza desde la perspectiva de género las prácticas del proceso alimentario entre migrantes pendulares y asentados en Miguel Alemán, Sonora. A partir de observaciones y entrevistas a profundidad a 21 migrantes, analizamos la relación entre el tipo de migración, estado civil, edad y tiempo de residencia en el lugar de destino. Para migrantes asentados, la participación de los hombres se relaciona con procesos de enfermedad y embarazo de las mujeres, mientras que los migrantes pendulares solos contratan servicios de comida, a pesar de que los más jóvenes saben cocinar. Concluimos que la participación de hombres en la alimentación es un cambio temporal, a nivel de prácticas y no cuestiona de fondo las normas hegemónicas de género.
Martín Martínez, José y Frasquet Bellver, Lidia: La donación Martínez Guerricabeitia
Authors: Ríos Moyano Sonia 
Published: October 2018

Cada vez que aparece una nueva publicación, -y especialmente en el ámbito de las Humanidades que es el que nos compete-, se culmina un largo proceso, una sucesión de etapas, que hacen que cada volumen sea único y especial. La donación Martínez Guerricabeitia. Catálogo Razonado forma parte de este género de obras que muestran la grandeza de dos términos -generosidad y trabajo-.
Habituarse a otra tierra. Exilio con la Antigüedad. Erwin Walter Palm en Santo Domingo
Authors: Von Kügelgen Helga 
Published: October 2018

Erwin Walter Palm (28/VIII/1910-7/VII/1988) filólogo y arqueólogo clásico, y su futura esposa Hilde Löwenstein (que sería conocida más tarde como la poetisa Hilde Domin) intuyeron el exterminio de los judios y dejaron en 1932 Heidelberg para seguir estudiando, doctorarse e investigar en Florencia y Roma. En 1939 tuvieron que irse a Inglaterra y en 1940 fueron a parar a la República Dominicana, en donde se quedaron 12 años. En Santo Domingo Palm descubre el Arte Colonial. Su conocimiento del mundo antiguo, medieval y moderno europeo -orientación en lo inhabitual- desveló la recepción de Europa que se encerraba en lo colonial. A causa de Hitler, Palm se convirtió en uno de los pioneros de los estudios y de la conservación de los monumentos coloniales. Sus publicaciones siguen siendo el punto de partida de la investigación y restauración.
Las ciudades históricas del Mediterráneo: el sector turístico, la dinamización cultural y las nuevas tecnologías aplicadas al Patrimonio Cultural
Authors: Calderón Roca Belén 
Published: October 2018

El curso celebrado durante el curso académico 2005-2006: Ciudades Históricas del Mediterráneo: el sector turístico, la dinamización cultural y las nuevas tecnologías aplicadas al Patrimonio Cultural [...] se encontraba inserto en el proyecto de la Unión Europea Euromed Heritage II: Patrimoines Partagés: Savoirs et savoir-faire apliques au patrimoine architectural et urbain des XIX-XX siècles en Méditerranée.
El color y el gesto: Carlos Barceló
Authors: Medina Torres Miguel Ángel 
Published: October 2018

Cuantos han escrito acerca de la obra artística de Carlos Barceló (Málaga, 1943) coinciden en señalar el absoluto protagonismo del color. Quien contempla sus pinturas percibe un estallido de tonalidades, una gran diversidad de gamas –a veces violentamente enfrentadas, otras complementándose- pero siempre en equilibrio.
Sánchez López, Juan Antonio. De Saulo a Paulo. Perspectiva iconográfica y dimensión artística del llamado "Apóstol de los Gentiles"
Authors: Herrera Sierra Francisco Javier 
Published: October 2018

Conjugar el hacia las ideas, incluso la fe, y el rigor científico en un estudio iconológico e iconográfico de una figura religiosa sea cristiana o de otro credo no es algo sencillo de resolver. Este libro supera satisfactoriamente este examen.
KIDNEY INJURY IN CANCER THERAPY
Authors: Burnasheva E. V. , Shatokhin Y. V. , Snezhko I. V. , Matsuga A. A. 
Published: October 2018

Кidney injury is a frequent and significant complication of cancer and cancer therapy. The kidneys are susceptible to injury from malignant infiltration, damage by metabolites of malignant cells, glomerular injury, nephrotoxic drugs including chemotherapeutic agents. Also bone marrow transplantation complications, infections with immune suppression (including septicemia), tumor lysis syndrome should be taken into account. Chemotherapeutic agents are a common cause of acute kidney injury but can potentially lead to chronic kidney disease development in cancer patients. This article summarizes risk factors of acute kidney injury in cancer patients. Risk factors are divided into two groups. The systemic are decrease of total circulating blood volume, infiltration of kidney tissue by tumor cells, dysproteinemia, electrolyte disturbances. The local (renal) risk factors are microcirculation disturbances, drugs biotransformation with formation of reactive oxygen intermediates, high concentration of nephrotoxic agents in proximal tubules and its sensitivity to ischemia. Drug-related risk factors include: drugs combination with cytotoxic effect high doses long term use necessity, direct cytotoxic effect of not only chemotherapeutic agents but also its metabolites, mean solubility forming intratubular precipitates. Early diagnosis, timely prevention and treatment of these complications provide significantly improve nononcologic results of treatment.
PROGNOSTIC SIGNIFICANCE OF SOME MARKERS OF ENDOTHELIAL DYSFUNCTION IN THE DEVELOPMENT OF CHRONIC KIDNEY PATHOLOGY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Agranovich N. V. , Pilipovich L. A. , Albotova L. V. 
Published: October 2018

Currently, accumulated a large amount of data on the role of inflammation in the vascular endothelium damage during the development of the chronic forms of many diseases. THE AIM: identification of endothelial dysfunction (ED) biomarkers as early predictors of CKD development in patients with chronic lung diseases. PATIENTS AND METHODS. 123 patients with COPD aged 55-79 years were examined, studied features of clinical and anthropometric parameters, data of the main biochemical systemic inflammation markers and vascular endothelial dysfunction, their significance in the development of chronic kidney disease (CKD). RESULTS. For the first time CKD was diagnosed in 51.2% of patients with COPD. In comorbid patients with COPD and related CKD noted more severe course of disease. Also in these patients detected significantly elevated endothelial dysfunction indices. CRP and fibrinogen levels were higher in all patients with COPD and authentically correlated with disease severety. Direct correlation between CRP and TNF-α levels was revealed. Noted that tumor necrosis factor was higher in smoker patients with COPD. Markers of kidneys endothelial dysfunction – homocysteine, IL-6, IL-8 – were significantly higher in patients with decreased GFR. Also in these patients were detected increased levels of serum creatinine and urea. Creatinine clearance inversely correlated with homocysteine plasma level. In all cases of fibrinogen increase in patients with COPD. Homocysteine level was also increased, but in combination with CKD it was significantly higher: respectively 19,8±7,51 and 39,8 ± 7,14 μmol/L, p<0,005. CONCLUSION. The received information confirms the hypothesis about the relationship of ED biomarkers homocysteine, TNF-α, IL-6, IL-8 with the development of chronic kidney disease in comorbid patients with COPD.
SOME ASPECTS OF VULVOVAGINITIS CHRONIZATION IN GIRLS WITH URINARY TRACT INFECTIONS
Authors: Chebotareva Yu. Y. , Letifov H. M. , Kostoeva Z. A. 
Published: October 2018

THE AIM: to evaluate the effectiveness of complex immunomodulatory therapy of vulvovaginitis in preschool children with urinary tract infection (UTI) by studying the features of vaginal microbiocenosis and immune status.PATIENTS AND METHODS. Prospective controlled randomized study was conducted in 94 girls aged 3-6 years with vulvovaginitis, of which 1 group (n=52) – vulvovaginitis with urinary tract infections; 2 group (n=42) – girls with isolated vulvovaginitis. 2 types of treatment were used: standard treatment and treatment with immunomodulatory drug comprising a recombinant interferon alpha-2b and high-level antioxidants – ascorbic acid and alpha- tocopherol acetate.RESULTS.Microscopic examination revealed type III vaginal smear in all patients. In 1-st group frequency of Gardnerella vaginalis, Esherichia coli, Сandida albicans isolation increased, in 2-nd group – Staphylococcus epidermidis, Enterococcus faecalis (microbial content more than 105 cfu/ml). In reviewing basic immunogram in girls og 1-st group revealed decrease of total content of CD3+CD8+- lymphocytes (0,82 [0,79;0,99]×109/l vs 1,27 [1,01;1,44]×109/l, p<0,05), CD3-CD16+CD56+-lymphocytes (0,29 [0,26; 0,32] × 109/l vs 0,48 [0,41; 0,5] × 109/l, p<0,05), CD3-CD19+-lymphocytes (0,54 [0,5;0,61] × 109/l vs 0,98 [0,91;1,14] × 109/l in control, p<0,05). After complex treatment in 1-st group decreased microbial colonizations of E.coli from 6,8±0,05×106 to 1,7±0,03×102 cfu/ml, р<0,05; in2-nd group – Staphylococcus epidermidis from 3,6±0,02×106 to 1,5±0,2×102 cfu/ml, р<0,05, and in vaginal smear noted normocenosis.CONCLUSION.Anti-inflammatory therapy of vulvovaginitis in girls with urinary tract infections, including the use of a complex antiviral immunomodulatory drug containing recombinant interferon α2b and highly active antioxidants – ascorbic acid and alpha tocopherol acetate improves the condition of the vaginal biotope, immune status, reduces the rates of microbial colonization, number of vulvovaginitis relapses.