bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term olfaction outcomes in transnasal endoscopic skull‐base surgery: a prospective cohort study comparing electrocautery and cold knife upper septal limb incision techniques
Authors: Puccinelli Cassandra L. , Yin Linda X. , O'Brien Erin K. , Van Gompel Jamie J. , Choby Garret W. , Van Abel Kathryn M. , Janus Jeffrey R. , Stokken Janalee K. 
Published: January 2019

BackgroundOlfactory nerve fibers are at risk of injury during transnasal endoscopic skull‐base approaches. Olfactory outcomes for various techniques have not been thoroughly investigated. This study aims to report long‐term olfactory outcomes when a cold knife upper septal limb incision technique is used compared to monopolar cautery.MethodsA prospective cohort study was performed at a tertiary referral center. Adult patients undergoing endoscopic approaches with septal incisions were randomized to cold knife or monopolar cautery groups. Patient demographics, clinical history, surgical data, and outcomes were collected. Preoperative, 3‐month, and 12‐month postoperative scores on the University of Pennsylvania Smell Inventory Test (UPSIT) and 22‐item Sino‐Nasal Outcome Test (SNOT‐22) were measured. Fisher's exact tests were performed for categorical variables and t tests were performed for continuous variables.ResultsTwenty‐two (22) patients (10 cold knife, 12 cautery) were enrolled between March 2016 and August 2017. The average age ± standard deviation was 50.2 ± 14.0 years (p = 0.59), 54% (p = 0.69) were female, and the primary pathology was pituitary adenoma (73%, p = 1.00). Preoperative, 3‐month, and 12‐month postoperative UPSIT scores were similar between the cold knife and cautery groups (32.8 vs 32.4, p = 0.80; 33.1 vs 33.0, p = 0.96; 33.6 vs 33.3, p = 0.84). On the “sense of smell/taste” question of the SNOT‐22, there was also no difference at all time points (p > 0.22).ConclusionThere was no significant change in patient UPSIT scores 1 year after transnasal skull‐base approaches, and no short‐term or long‐term differences between cold knife and cautery upper septal limb incision techniques. Our study supports an individualized approach based on surgeon preference.
Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review
Authors: Safi Chetan , Li Carol , Tabaee Abtin , Ramakrishna Rohan , Riley Charles A. 
Published: January 2019

BackgroundRespiratory epithelial adenomatoid hamartoma (REAH) is a recently classified histopathologic diagnosis often identified incidentally following endoscopic sinus surgery (ESS) for presumed chronic rhinosinusitis. Limited data exist defining preoperative imaging features and surgical outcomes. The purpose of this study is to examine characteristic imaging findings of REAH and postoperative olfactory and recurrence outcomes.MethodsA systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines on articles published from 1995 to present. PubMed, EMBASE, and Ovid MEDLINE databases were queried for studies pertinent to imaging findings of REAH and surgical outcomes. Quality of articles was assessed using the Methodological Index for Non‐Randomized Studies (MINORS).ResultsA total of 294 articles were identified, with 15 meeting inclusion criteria. Seven articles assessed both imaging findings and surgical outcomes. Three articles focused exclusively on imaging, whereas 5 examined surgical outcomes. Olfactory cleft (OC) widening greater than 10 mm on computed tomography (CT) was characteristic of REAH. A total of 441 patients with REAH were included; 221 patients (50.1%) had concurrent nasal polyposis, whereas 154 patients (34.9%) had isolated REAH. Surgical intervention ranged from simple excision to complete ESS. Sixty‐five percent (65%) of patients reported improved olfaction; 4.1% of patients recurred with follow‐up ranging from 4 months to 5 years.ConclusionA widened OC may suggest the presence of REAH. This disease process has been identified in patients with nasal polyposis or encountered as an isolated lesion. Targeted surgery may result in improved olfaction and a low likelihood of recurrence, though long‐term prospective studies are necessary.
Racemic Vinylallenes in Catalytic Enantioselective Multicomponent Processes: Rapid Generation of Complexity through 1,6‐Conjugate Additions
Authors: Huang Youming , Torker Sebastian , Li Xinghan , del Pozo Juan , Hoveyda Amir H. 
Published: January 2019

AbstractRacemic vinylallenes are shown to be effective substrates for catalytic multicomponent diastereo‐ and enantioselective 1,6‐conjugate addition of multifunctional allyl moieties to easily accessible α,β,γ,δ‐unsaturated diesters. Reactions may be catalyzed by 5.0 mol % of a readily accessible NHC‐Cu complex at ambient temperature, and other than a vinylallene, involve B2(pin)2 and an α,β,γ,δ‐unsaturated diester. A variety of vinylallenes were converted to products bearing a Z‐trisubstituted alkenyl‐B(pin) moiety, a vinyl group, a β,γ‐unsaturated diester unit, and vicinal stereogenic centers in up to 67 % yield, 87:13 Z/E ratio, >98:2 d.r., and 98:2 e.r. Chemoselective modifications involving the alkenyl‐B(pin), the vinyl, or the 1,2‐disubstituted olefin moieties were carried out to demonstrate versatility and utility. Stereochemical models, based on mechanistic and DFT studies, demonstrate the dynamic behavior of intermediated Cu‐allyl species and account for various selectivity profiles.
Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy
Authors: Zhang Boyu , Wang Fei , Zhou Hua , Gao Duyang , Yuan Zhen , Wu Changfeng , Zhang Xuanjun 
Published: January 2019

AbstractSemiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. Liposomes were employed as nanoreactors to confine the Pdot photocatalyst, reactants, intermediates, and by‐products. Upon photon absorption by the Pdots, the catalytic cycle is initiated and repeated within the aqueous interior, while the H2 product diffuses across the lipid bilayer to counteract reactive oxygen species (ROS) overexpressed in diseased tissues. Ensemble and single‐particle Förster resonance energy transfer microscopy confirmed the proposed nanoreactor model. We demonstrate that a liposomal nanoreactor containing Pdots and a sacrificial electron donor is a potential photocatalytic nanoreactor for in situ hydrogen therapy.
Control of Excited‐State Conformations in B,N‐Acenes
Authors: Lu Zhenpin , Quanz Henrik , Ruhl Julia , Albrecht Georg , Logemann Christian , Schlettwein Derck , Schreiner Peter R. , Wegner Hermann A. 
Published: January 2019

AbstractWe present a new concept to control the conformations of molecules in the excited state through harvesting negative hyperconjugation. The strategy was realized with the 2,3,1,4‐benzodiazadiborinane scaffold, which was prepared by a new synthetic procedure. Photochemical studies identified dual light emission, which was assigned to well‐defined conformers. The emission at longer wavelength can be switched off by restricting the rotational degrees of freedom in the solid state as well as by controlling the energy levels of the excited states through adjusting the solvent polarity.
Lugdunomycin, an Angucycline‐Derived Molecule with Unprecedented Chemical Architecture
Authors: Wu Changsheng , van der Heul Helga U. , Melnik Alexey V. , Lübben Jens , Dorrestein Pieter C. , Minnaard Adriaan J. , Choi Young Hae , van Wezel Gilles P. 
Published: January 2019

AbstractThe angucyclines form the largest family of polycyclic aromatic polyketides, and have been studied extensively. Herein, we report the discovery of lugdunomycin, an angucycline‐derived polyketide, produced by Streptomyces species QL37. Lugdunomycin has unique structural characteristics, including a heptacyclic ring system, a spiroatom, two all‐carbon stereocenters, and a benzaza‐[4,3,3]propellane motif. Considering the structural novelty, we propose that lugdunomycin represents a novel subclass of aromatic polyketides. Metabolomics, combined with MS‐based molecular networking analysis of Streptomyces sp. QL37, elucidated 24 other rearranged and non‐rearranged angucyclines, 11 of which were previously undescribed. A biosynthetic route for the lugdunomycin and limamycins is also proposed. This work demonstrates that revisiting well‐known compound families and their producer strains still is a promising approach for drug discovery.
Enzyme‐Modulated Anaerobic Encapsulation of Chlorella Cells Allows Switching from O2 to H2 Production
Authors: Su Dongyue , Qi Jiarui , Liu Xiaoman , Wang Lei , Zhang Hao , Xie Hui , Huang Xin 
Published: January 2019

AbstractSingle‐cell encapsulation has become an effective strategy in cell surface engineering; however, the construction of cell wall‐like layers that allow the switching of the inherent functionality of the engineered cell is still rare. In this study, we show a universal way to create an enzyme‐modulated oxygen‐consuming sandwich‐like layer by using polydopamine, laccase, and tannic acid as building blocks, which then could generate an anaerobic microenvironment around the cell. This layer protected the encapsulated C. pyrenoidosa cell against external stresses and enabled it to switch from normal photosynthetic O2 production to photobiological H2 production. The layer showed an smaller effect on the PSII activity, which contributed a significant enhancement on the rate (0.32 μmol H2 h−1 (mg chlorophyll)−1) and the duration (7 d) of H2 production. This strategy is expected to provide a pathway for modulating the functionality of cells and for breakthroughs in the development of green energy alternatives.
Adenine Components in Biomimetic Metal–Organic Frameworks for Efficient CO2 Photoconversion
Authors: Li Ning , Liu Jiang , Liu Jing‐Jing , Dong Long‐Zhang , Xin Zhi‐Feng , Teng Yun‐Lei , Lan Ya‐Qian 
Published: January 2019

AbstractVisible‐light driven photoconversion of CO2 into energy carriers is highly important to the natural carbon balance and sustainable development. Demonstrated here is the adenine‐dependent CO2 photoreduction performance in green biomimetic metal–organic frameworks. Photocatalytic results indicate that AD‐MOF‐2 exhibited a very high HCOOH production rate of 443.2 μmol g−1 h−1 in pure aqueous solution, and is more than two times higher than that of AD‐MOF‐1 (179.0 μmol g−1h−1) in acetonitrile solution. Significantly, experimental and theoretical evidence reveal that the CO2 photoreduction reaction mainly takes place at the aromatic nitrogen atom of adenine molecules through a unique o‐amino‐assisted activation rather than at the metal center. This work not only serves as an important case study for the development of green biomimetic photocatalysts used for artificial photosynthesis, but also proposes a new catalytic strategy for efficient CO2 photoconversion.
Profiling of the Beneficial and Potentially Harmful Components of Trichodesma indicum Seed and Seed Oil Obtained by Ultrasound‐Assisted Extraction
Authors: Górnaś Paweł , Picron Jean‐François , Perkons Ingus , Mišina Inga , Rudzińska Magdalena , Sobieszczańska Natalia , Chakradhari Suryakant , Patel Khageshwar Singh 
Published: January 2019

AbstractThe beneficial and potentially harmful bioactive components in the seeds and seed oil of Trichodesma indicum L. (Boraginaceae) were investigated in the present study. The T. indicum seeds were rich in oil (29.0%), phenolic compounds (PC, 1881.2 mg per 100 g), and pyrrolizidine alkaloids (PA, 2,702,338 ng g−1). Seven PC were identified in T. indicum seeds by liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry system (LC‐Q‐TOF‐MS). Rosmarinic acid (67%) and isomers of salvianolic acid B/E/L (26%) were the main phenolics, while melitric acid A and sebestenoid C/D constituted 6% and 1%, respectively. Only a minor part of the total PC and PA was transferred from the seeds into the oil fraction during the extraction procedure (<0.03%). The T. indicum seed oil was predominated by the following polyunsaturated fatty acids (PUFA):linoleic (23.2%), γ‐linolenic (6.0%), α‐linolenic (26.8%), and stearidonic (5.9%). High levels were also observed for oleic (26.7%) and palmitic (7.4%) acids. Additionally, notable amounts of γ‐tocopherol (92% of total tocochromanols) and β‐sitosterol (53% of total sterols) were found in T. indicum seed oil. The total content of tocochromanols, sterols, and carotenoids in T. indicum seed oil was 102.7, 236.0, and 0.6 mg per 100 g oil, respectively. Among 10 detected hepatotoxic PA in T. indicum seeds, intermedine/lycopsamine/indicine (90.9%), intermedine N‐oxide (4.9%), and lycopsamine N‐oxide (4.1%) consisted 99.9% of the total PA concentration. The T. indicum seeds should be used carefully due to the presence of PA.
Feature‐based recursive observer design for homography estimation and its application to image stabilization
Authors: Hua Minh‐Duc , Trumpf Jochen , Hamel Tarek , Mahony Robert , Morin Pascal 
Published: January 2019

AbstractThis paper presents a new algorithm for online estimation of a sequence of homographies applicable to image sequences obtained from robotic vehicles equipped with vision sensors. The approach taken exploits the underlying Special Linear group structure of the set of homographies along with gyroscope measurements and direct point‐feature correspondences between images to develop temporal filter for the homography estimate. Theoretical analysis and experimental results are provided to demonstrate the robustness of the proposed algorithm. The experimental results show excellent performance and robustness even in the case of very fast camera motions (relative to frame rate) and severe occlusions.
A Comparison of Formation Methods for Graphite//LiFePO4 Cells
Authors: Moretti Arianna , Sharova Varvara , Carvalho Diogo V. , Boulineau Adrien , Porcher Willy , de Meatza Iratxe , Passerini Stefano 
Published: January 2019

AbstractThe sequence of initial cycles necessary for the build‐up of the solid electrolyte interphase (SEI) on the anode surface of Li‐ion batteries (usually called formation) is a cost‐ and time‐consuming process, thus requiring further optimization. Herein, three different protocols are compared to explore possibilities to reduce the formation time of the cells without negatively affecting the electrochemical performance. XPS and HRTEM analyses are used to identify the main characteristics of the as formed SEIs. Electrochemical tests are conducted on full lithium‐ion cells using state‐of‐the‐art graphite and LiFePO4 electrodes. The time‐saving dual‐current protocol results in excellent cycling performance, and in a LiF‐rich SEI. Interestingly, the use of moderately high temperature (40 °C) does not strongly affect the SEI composition as evidenced by XPS analysis. On the other hand, the formation rate determines the degree of graphite surface amorphization, visualized by HRTEM.
Retracted: 14‐3‐3ζ promotes gliomas cells invasion by regulating Snail through the PI3K/AKT signaling
Authors: Li Junjun , Xu Hao , Wang Qiangping , Wang Sihua , Xiong Nanxiang 
Published: January 2019

Abstract14‐3‐3ζ has been reported to function as critical regulators of diverse cellular responses. However, the role of 14‐3‐3ζ in gliomas progression remains largely unknown. The expression level of 14‐3‐3ζ and Snail was detected by Western blot analysis and quantitative polymerase chain reaction in different grades of human gliomas. The effect of 14‐3‐3ζ on gliomas progression was measured using cell migration and invasion assay, the colony formation experiment, and CCK‐8 assay. The effect of 14‐3‐3ζ on PI3K/AKT/Snail signaling protein expression levels was tested by Western blotting. Firstly, 14‐3‐3ζ was often up‐regulated in high‐grade gliomas relative to low‐grade gliomas, and this overexpression was significantly related to tumor size, Karnofsky Performance Scale score and weaker disease‐free survival. Secondly, the overexpression of 14‐3‐3ζ promoted gliomas cells proliferation, migration, and invasion. Conversely, the knockdown of 14‐3‐3ζ suppressed gliomas cells proliferation, migration, and invasion. Furthermore, subsequent mechanistic studies showed that 14‐3‐3ζ could activate PI3K/AKT/Snail signaling pathway to facilitate gliomas cells proliferation, migration, and invasion. This study shows that the overexpression of 14‐3‐3ζ can promote remarkably gliomas cells proliferation, migration, and invasion by regulating the Snail protein expression through activating PI3K/AKT signaling, and it may serve as a potential prognostic marker and therapeutic target for gliomas.
Synthesis and Biological Activity of New 4‐tert‐Butylcyclohexanone Derivatives
Authors: Kozioł Agata , Jasnowski Mateusz , Grela Ewa , Szczepanik Maryla , Gabryś Beata , Dancewicz Katarzyna , Lochyński Stanisław 
Published: January 2019

AbstractIn the synthesis performed in this study, derivatives of 4‐tert‐butylcyclohexanone 1 were obtained using typical reactions of organic synthesis. The bioactivity of the selected compounds was evaluated. 1‐(Bromomethyl)‐8‐tert‐butyl‐2‐oxaspiro[4.5]decan‐3‐one (5) was characterized by attractant properties against larvae and a weak feeding deterrent activity against adults of Alphitobius diaperinus Panzer. This bromolactone was a moderate antifeedant towards Myzus persicae Sulzer. In addition, ethyl (4‐tert‐butylcyclohexylidene)acetate (2) and bromolactone 5 displayed antibacterial activity. The strongest bacteriostatic effect was observed against Gram‐positive strains: Bacillus subtilis and Staphylococcus aureus. The bromolactone 5 also limited the growth of Escherichia coli strain.
Light‐Wavelength‐Based Quantitative Control of Dihydrofolate Reductase Activity by Using a Photochromic Isostere of an Inhibitor
Authors: Mashita Takato , Kowada Toshiyuki , Takahashi Hiroto , Matsui Toshitaka , Mizukami Shin 
Published: January 2019

AbstractPhotopharmacology has attracted research attention as a new tool for achieving optical control of biomolecules, following the methods of caged compounds and optogenetics. We have developed an efficient photopharmacological inhibitor—azoMTX—for Escherichia coli dihydrofolate reductase (eDHFR) by replacing some atoms of the original ligand, methotrexate, to achieve photoisomerization properties. This fine molecular design enabled quick structural conversion between the active “bent” Z isomer of azoMTX and the inactive “extended” E isomer, and this property afforded quantitative control over the enzyme activity, depending on the wavelength of irradiating light applied. Real‐time photoreversible control over enzyme activity was also achieved.
Use of prasugrel and clinical outcomes in African‐American patients treated with percutaneous coronary intervention for acute coronary syndromes
Authors: Faggioni Michela , Baber Usman , Chandrasekhar Jaya , Sartori Samantha , Weintraub William , Rao Sunil V. , Vogel Birgit , Claessen Bimmer , Kini Annapoorna , Effron Mark , Ge Zhen , Keller Stuart , Strauss Craig , Snyder Clayton , Toma Catalin , Weiss Sandra , Aquino Melissa , Baker Brian , Defranco Anthony , Bansilal Sameer , Muhlestein Brent , Kapadia Samir , Pocock Stuart , Poddar Kanhaiya L. , Henry Timothy D. , Mehran Roxana 
Published: January 2019

AbstractObjectiveTo investigate the use of prasugrel after percutaneous coronary intervention (PCI) in African American (AA) patients presenting with acute coronary syndrome (ACS).BackgroundAA patients are at higher risk for adverse cardiovascular outcomes after PCI and may derive greater benefit from the use of potent antiplatelet therapy.MethodsUsing the multicenter PROMETHEUS observational registry of ACS patients treated with PCI, we grouped patients by self‐reported AA or other races. Clinical outcomes at 90‐day and 1‐year included non‐fatal myocardial infarction (MI), major adverse cardiac events (composite of death, MI, stroke, or unplanned revascularization) and major bleeding.ResultsThe study population included 2,125 (11%) AA and 17,707 (89%) non‐AA patients. AA patients were younger, more often female (46% vs. 30%) with a higher prevalence of diabetes mellitus, chronic kidney disease, and prior coronary intervention than non‐AA patients. Although AA patients more often presented with troponin (+) ACS, prasugrel use was much less common in AA vs. non‐AA (11.9% vs. 21.4%, respectively, P = 0.001). In addition, the use of prasugrel increased with the severity of presentation in non‐AA but not in AA patients. Multivariable logistic regression showed AA race was an independent predictor of reduced use of prasugrel (0.42 [0.37–0.49], P < 0.0001). AA race was independently associated with a significantly higher risk of MI at 90‐days and 1 year after PCI.ConclusionsDespite higher risk clinical presentation and worse 1‐year ischemic outcomes, AA race was an independent predictor of lower prasugrel prescription in a contemporary population of ACS patients undergoing PCI.
Urothelial neoplasm in a 19‐year‐old male patient with urine discoloration, negative lab, and imaging workup: Should we investigate the findings or the symptom?
Authors: Symeonidis Evangelos N. , Symeonidis Asterios , Gkekas Chrysovalantis , Georgiadis Christos , Malioris Apostolos , Papathanasiou Michail 
Published: January 2019

Key Clinical MessageWith few cases of PUNLMPs in young adults being reported in the literature, we hope to raise clinical awareness of prompt and effective diagnosis, while maintaining a high index of suspicion among health professionals. Even in the absence of red blood cells in the urine and subsequent negative imaging workup, clinicians should not delay performance of diagnostic cystoscopy.
Beyond Cars: Fischer‐Tropsch Synthesis for Non‐Automotive Applications
Authors: Sun Jian , Yang Guohui , Peng Xiaobo , Kang Jincan , Wu Jinhu , Liu Guangbo , Tsubaki Noritatsu 
Published: January 2019

AbstractAs a century‐old classical reaction, Fischer‐Tropsch (F‐T) synthesis is undergoing new developments especially in its applications of producing jet fuel, olefins, aromatics and oxygenated chemicals, which are completely different from the conventional F‐T product, gasoline, diesel and wax. Producing above new products is not obeying famous ASF distribution law, requiring revolutionary design of new F‐T catalysts and reaction pathways. A mass of new research directions on F‐T synthesis for these liquid fuels and high‐value chemicals are successfully proposed. This review spotlights recent new advances based on F‐T synthesis for non‐automotive applications, and discusses its new possible directions in future.