bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary Constitution Making in Asia-Pacific
Authors: De Visser Maartje , Bui Ngoc Son 
Published: October 2019

Abstract
This special issue features a curated set of contextualized case studies that interrogate how six Asian countries have calibrated global imperatives with domestic desires and concerns during the drafting of their latest constitution. Read together, the accounts demonstrate that the impact of globalization on what has long been thought of as a quintessential exercise of national sovereignty is ubiquitous, yet that the precise combination of the global and the local is unique to each country, determined as it is by the strength of domestic interests and factions. Taking contextualized functionalism as its premise, this introduction sketches the contours of an analytical framework to study constitution-making processes in a globalized environment. By implication, this framework is conceived in a neutral fashion and cast in functional terminology that extrapolates from the circumstances of the countries featured in this Special Issue. This, we hope, will make it a helpful toolbox to make sense of the global-local interplay in constitution-making in any country, whether located in Asia or further afield.
Peripartum cardiomyopathy: basic mechanisms and hope for new therapies
Authors: Ricke-Hoch Melanie , Pfeffer Tobias J , Hilfiker-Kleiner Denise 
Published: October 2019

Abstract
Peripartum cardiomyopathy (PPCM) is a life-threatening cardiomyopathy characterized by acute or slow progression of left ventricular (LV) systolic dysfunction (LV ejection fraction of &lt;45%) late in pregnancy, during delivery, or in the first postpartum months, in women with no other identifiable causes of heart failure. PPCM patients display variable phenotypes and risk factor profiles, pointing to involvement of multiple mechanisms in the pathogenesis of the disease. The higher risk for PPCM in women with African ancestry, the prevalence of gene variants associated with cardiomyopathies, and the high variability in onset and disease progression in PPCM patients also indicate multiple mechanisms at work. Experimental data have shown that different factors can induce and drive PPCM, including inflammation and immunity, pregnancy hormone impairment, catecholamine stress, defective cAMP-PKA, and G-protein-coupled-receptor signalling, and genetic variants. However, several of these mechanisms may merge into a common major pathway, which includes unbalanced oxidative stress and the cleavage of the nursing hormone prolactin (PRL) into an angiostatic, pro-apoptotic, and pro-inflammatory 16 kDa-PRL fragment, resulting in subsequent vascular damage and heart failure. Based on this common pathway, potential disease-specific biomarkers and therapies have emerged. Despite commonalities, the variation in aetiology and mechanisms poses challenges for the diagnosis, treatment, and management of the disease. This review summarizes current knowledge on the clinical presentation of PPCM in the context of recent experimental research. It discusses the challenge to develop disease-specific biomarkers in the context of rapid changing physiology in the peripartum phase, and outlines possible future treatment and management strategies for PPCM patients.
Auditory, Social, and Behavioral Skills of Children With Unilateral/Mild Hearing Loss
Authors: Nassrallah Flora , Tang Ken , Whittingham JoAnne , Sun Huidan , Fitzpatrick Elizabeth M 
Published: October 2019

Abstract
This study explored the impact of mild bilateral or unilateral hearing loss on auditory, social, and behavior skills in early school-aged children. Thirty-two children (aged 5–9 years) were evaluated with parent and teacher questionnaires. Most outcomes were within the range of expected scores. However, functional auditory skills were below published results for children with typical hearing. On the social skills scale, about 21.4% (parent-reported) and 20.0% (teacher-reported) of children were below one standard deviation (SD) of the normative mean (i.e., a standard score below 85). On the parent-reported behavior test, over a quarter of children scored beyond 1 SD on some subscales. Laterality of hearing loss had no effect on outcomes (p &gt; .05). Agreement between parents and teachers varied from poor (intraclass correlation coefficient [ICC]: .162) to moderate (ICC: .448). Results indicate that these children are functioning in most areas like their peers with typical hearing. Additional research on this population of children who may benefit from early identification and amplification is warranted.
Signing Exact English Transliteration: Effects of Accuracy and Lag Time on Message Intelligibility
Authors: Krause Jean C , Hague Andrew K 
Published: October 2019

Abstract
This paper, the fourth in a series concerned with the level of access afforded to students who use educational interpreters, focuses on the intelligibility of interpreters who use Signing Exact English (SEE). Eight expert receivers of SEE were employed to evaluate the intelligibility of transliterated messages that varied in accuracy and lag time. Results of intelligibility tests showed that, similar to Cued Speech transliterators, (a) accuracy had a large positive effect on transliterator intelligibility, (b) overall intelligibility (69%) was higher than average accuracy (58%), and (c) the likelihood that an utterance reached 70% intelligibility was somewhat sigmoidal in shape, with the likelihood of reaching 70% intelligibility dropping off fastest for accuracy values &lt;65%. Accuracy alone accounted for 53% of the variance in transliterator intelligibility; mouthing was identified as a secondary factor that explained an additional 11%. Although lag time accounted for just .4% of the remaining variance, utterances produced with lag times between .6 and 1.2 s were most likely to exceed 70% intelligibility. With 36% of the variance still unexplained, other sources of transliterator variability (for example, facial expression, nonmanual markers, and mouth/sign synchronization) may also play a role in intelligibility and should be explored in future research.
Two rare complications of myocardial infarction: a case report
Authors: Mahmoud Osama , Mehra Vishal 
Published: October 2019

Abstract

Background
Mechanical complications following myocardial infarction (MI) have decreased in incidence due to the widespread use of early percutaneous coronary revascularization methods. We describe two rare complications as well as their natural history and uncertainties of the ideal management approach.

Case summary
Sixty-two-year-old female with multiple cardiovascular disease risk factors who had a delayed presentation of ST-segment elevation myocardial infarction and went on to develop dissecting intramyocardial haematoma progressing to ventricular septal rupture and coronary ventricular fistula.

Discussion
Intramyocardial haematoma is a rare complication of MI. It is considered to be part of the continuum of myocardial rupture which our patient eventually developed in the form of ventricular septal defect. The second rare entity in the same patient was development of a coronary ventricular fistula of the infarct-related stented, artery. The best way of managing dissecting intramyocardial haematoma is unclear with conflicting data between conservative and invasive strategies. Our patient failed the conservative approach as she progressed to frank myocardial rupture.
Universal implantation of temporary epicardial pacing wires after surgery for congenital heart disease: necessity or luxury?
Authors: Perumal Gopinath , Marathe Supreet Prakash , Betts Kim S , Suna Jessica , Morwood Jim , Wildschut Jason , Mattke Adrian C , Alphonso Nelson , Venugopal Prem 
Published: October 2019

AbstractOBJECTIVESRoutine implantation of temporary epicardial pacing wires after surgery for congenital heart disease (CHD) has recently been questioned. We evaluated the incidence of arrhythmias, arrhythmias causing haemodynamic compromise and the safety of a strategy of selective implantation of pacing wires in our unit.METHODSAll patients who underwent surgery for CHD using cardiopulmonary bypass between September 2015 and December 2016 were retrospectively enrolled in the study (n = 313). Patients were stratified into group A (universal implantation) and group B (selective implantation). Group B received pacing wires only when postoperative rhythm disturbances were anticipated based on the operating surgeon’s judgement. The primary outcome was arrhythmia causing haemodynamic compromise. Outcomes were compared between unmatched and propensity matched groups.RESULTSForty-eight patients experienced an arrhythmia causing haemodynamic compromise (15.3%). Twenty-three patients (7.3%) experienced an arrhythmia causing haemodynamic compromise that required the use of pacing wires for therapeutic purposes (group A n = 13, group B n = 10, P = 0.34). There were no pacing wire related complications in either group. All patients in group A and 90% in group B had pacing wires when needed (P = 0.435). In group A, 89% of patients had pacing wires which were not used compared with 13% in group B (P < 0.001). Results were unchanged when repeated using propensity matching (81 pairs).CONCLUSIONSThe probability of developing a postoperative arrhythmia requiring therapeutic pacing can be predicted using the risk factors identified in our study. The routine implantation of pacing wires after surgery for CHD is not necessary. A measured reduction from universal implantation is safe.
Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction
Authors: Kahles Florian , Rückbeil Marcia V , Mertens Robert W , Foldenauer Ann C , Arrivas Maria C , Moellmann Julia , Lebherz Corinna , Biener Moritz , Giannitsis Evangelos , Katus Hugo A , Marx Nikolaus , Lehrke Michael 
Published: October 2019

Abstract

Aims
Glucagon-like peptide 1 (GLP-1) is a gut incretin hormone inducing post-prandial insulin secretion. Glucagon-like peptide 1 levels were recently found to be increased in patients with acute myocardial infarction. Glucagon-like peptide 1 receptor agonists improve cardiovascular outcomes in patients with diabetes. The aim of this study was to assess the predictive capacity of GLP-1 serum levels for cardiovascular outcome in patients with myocardial infarction.

Methods and results
In 918 patients presenting with myocardial infarction [321 ST-segment elevation myocardial infarction and 597 non-ST-segment elevation myocardial infarction (NSTEMI)] total GLP-1, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and the Global Registry of Acute Coronary Events (GRACE) score were assessed at time of hospital admission. The primary composite outcome of the study was the first occurrence of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke. Kaplan–Meier survival plots and univariable Cox regression analyses found GLP-1 to be associated with adverse outcome [hazard ratio (HR) of logarithmized GLP-1 values: 6.29, 95% confidence interval (CI): 2.67–14.81; P &lt; 0.0001]. After further adjustment for age, sex, family history of cardiovascular disease, smoking, diabetes, hypertension, hypercholesterinaemia, glomerular filtration rate (GFR) CKD-EPI, hs-CRP, hs-Troponin T, and NT-proBNP levels the HR remained significant at 10.98 (95% CI: 2.63–45.90; P = 0.0010). Time-dependent receiver operating characteristic curve analyses illustrated that GLP-1 levels are a strong indicator for early events. For events up to 30 days after admission, GLP-1 proved to be superior to other biomarkers including hs-Troponin T, GFR CKD-EPI, hs-CRP, and NT-proBNP. Adjustment of the GRACE risk estimate by addition of GLP-1 increased the area under the receiver operating characteristic curve over time in NSTEMI patients.

Conclusion
In patients hospitalized for myocardial infarction, GLP-1 levels are associated with cardiovascular events.
Early improvement of left ventricular ejection fraction by cardiac resynchronization through His bundle pacing in patients with heart failure
Authors: Moriña-Vázquez Pablo , Moraleda-Salas María Teresa , Manovel-Sánchez Ana José , Fernández-Gómez Juan Manuel , Arce-Léon Álvaro , Venegas-Gamero José , Barba-Pichardo Rafael 
Published: October 2019

Abstract

Aims
Permanent His bundle pacing (p-HBP) can correct intraventricular conduction disorders and could be an alternative to traditional cardiac resynchronization therapy (CRT) via the coronary sinus. We describe the short-term impact of HBP on left ventricular ejection fraction (LVEF) and improvement of left intraventricular synchrony.

Methods and results
This prospective descriptive study, performed from January 2018 to February 2019, included patients with left bundle branch block (LBBB) and an CRT indication who were resynchronized by p-HBP. We used the Medtronic C315 His catheter or a combination of the CPS-Direct-Universal introducer, CPS-AIM™-Universal subselector (Abbot), and SelectSecure™ MRI-SureScan™ 3830 lead. Correction of the LBBB by HBP had been previously checked. At 1 month of follow-up, we analysed the quantification of LVEF and measurement of the delay of the septal wall with the posterior wall as a parameter of intraventricular synchrony. We included 48 patients with LBBB and an indication for CRT. With HBP, we corrected the LBBB in 81% of patients (n = 39), and we achieved cardiac resynchronization through permanent HBP in 92% of these patients (n = 36). Left ventricular ejection fraction and intraventricular mechanical resynchronization improved in all patients, which was demonstrated by echocardiography through the improvement of the delay of the septal wall with the posterior wall from 138 ms (range 131–151) to 41 ms (19–63).

Conclusion
There is early improvement after p-HBP in LVEF and left ventricular electromechanical synchronization in patients with LBBB, heart failure, and an indication for CRT.
Evaluating a combined bowel preparation for small-bowel capsule endoscopy: a prospective randomized–controlled study
Authors: Hansel Stephanie L , Murray Joseph A , Alexander Jeffrey A , Bruining David H , Larson Mark V , Mangan Thomas F , Dierkhising Ross A , Almazar Ann E , Rajan Elizabeth 
Published: October 2019

Abstract

Background
Capsule endoscopy (CE) is frequently hindered by intra-luminal debris. Our aim was to determine whether a combination bowel preparation would improve small-bowel visualization, diagnostic yield, and the completion rate of CE.

Methods
Single-blind, prospective randomized–controlled study of outpatients scheduled for CE. Bowel-preparation subjects ingested 2 L of polyethylene glycol solution the night prior to CE, 5 mL simethicone and 5 mg metoclopramide 20 minutes prior to CE and laid in the right lateral position 30 minutes after swallowing CE. Controls had no solid food after 7 p.m. the night prior to CE and no liquids 4 hours prior to CE. Participants completed a satisfaction survey. Capsule readers completed a small-bowel-visualization assessment.

Results
Fifty patients were prospectively enrolled (56% female) with a median age of 54.4 years and 44 completed the study (23 patients in the control group and 21 in the preparation group). There was no significant difference between groups on quartile-based small-bowel visualization (all P &gt; 0.05). There was no significant difference between groups in diagnostic yield (P = 0.69), mean gastric (P = 0.10) or small-bowel transit time (P = 0.89). The small-bowel completion rate was significantly higher in the preparation group (100% vs 78%; P = 0.02). Bowel-preparation subjects reported significantly more discomfort than controls (62% vs 17%; P = 0.01).

Conclusions
Combined bowel preparation did not improve small-bowel visualization but did significantly increase patient discomfort. The CE completion rate improved in the preparation group but the diagnostic yield was unaffected. Based on our findings, a bowel preparation prior to CE does not appear to improve CE performance and results in decreased patient satisfaction (ClinicalTrials.gov, No. NCT01243736).
Regional crustal and lithospheric thickness model for Alaska, the Chukchi shelf, and the inner and outer bering shelves
Authors: Torne Montserrat , Jiménez–Munt Ivone , Vergés Jaume , Fernàndez Manel , Carballo Alberto , Jadamec Margarete 
Published: October 2019

SUMMARYThis study presents for the first time an integrated image of the crust and lithospheric mantle of Alaska and its adjacent western shelves of the Chukchi and Bering seas based on joint modelling of potential field data constrained by thermal analysis and seismic data. We also perform 3-D forward modelling and inversion of Bouguer anomalies to analyse density heterogeneities at the crustal level. The obtained crustal model shows northwest-directed long wavelength thickening (32–36 km), with additional localized trends of thicker crust in the Brooks Range (40 km) and in the Alaska and St Elias ranges (50 km). Offshore, 28–30-km-thick crust is predicted near the Bearing slope break and 36–38 km in the northern Chukchi Shelf. In interior Alaska, the crustal thickness changes abruptly across the Denali fault, from 34–36 to the north to above 30 km to the south. This sharp crustal thickness gradient agrees with the presence of a crustal tectonic buttress guiding block motion west and south towards the subduction zone. The average crustal density is 2810 kg m−3. The denser crust, up to 2910 kg m−3, is found south of the Denali Fault likely related to the oceanic nature of the Wrangellia Composite Terrane rocks. Offshore, less dense crust (<2800 kg m−3) is found along the sedimentary basins of the Chukchi and Beaufort shelves. At LAB levels, there is a regional SE–NW trend that coincides with the current Pacific Plate motion, with a lithospheric root underneath the Brooks Range, Northern Slope, and Chuckchi Sea, that may correspond to a relic of the Chukotka-Artic Alaska microplate. The obtained lithospheric root (above 180 km) agrees with the presence of a boundary of cold, strong lithosphere that deflects the strain towards the South. South of the Denali Fault the LAB topography is quite complex. East of 150°W, below Wrangellia and the eastern side of Chugach terranes, the LAB is much shallower than it is west of this meridian. The NW trending limit separating thinner lithosphere in the east and thicker in the west agrees with the two-tiered slab shape of the subducting Pacific Plate.
Accuracy of the moment-tensor inversion of far-field P waves
Authors: Kong Yue , Li Min , Chen Weimin , Kang Boqi 
Published: October 2019

SUMMARY
The far-field assumption is widely used and suitable for the moment-tensor inversion in which the source–receiver distance is quite long. However, the description of far field is uncertain and an explicit far-field range is missing. In this study, the explicit far-field range is determined and the errors of moment-tensor solutions produced by the far-field approximation are analysed. The distance, for which the far-field assumption is satisfied and the effect of the near-field term can be ignored, is directionally dependent. For the shear dislocation, in the directions near the nodal lines of the far-field P waves, the far-field distance is heavily dependent on the displacement component used to invert moment tensors. The radial component of displacement, which is parallel to the wave propagation direction, is recommended for the inversion and the corresponding far-field distance is quite short. In the directions far from the nodal lines, the selection of displacement components has little influence on the far-field distance. The maximum far-field distance appears in the directions of the pressure and tensile axes of the source and the value is about 30 wavelengths of radiated waves. Using more receivers (>6) in the moment-tensor inversion can shorten the far-field distance. The effect of the near-field term on the moment-tensor inversion for tensile dislocations and isotropic sources (explosion or implosion) can be ignored. The conclusions obtained in this study are helpful for determining the positions of receivers and evaluating the accuracy of moment-tensor solutions, with far-field assumption being applied in the inversion.
Energy Counterexamples in Two Weight Calderón–Zygmund Theory
Authors: Sawyer Eric T , Shen Chun-Yen , Uriarte-Tuero Ignacio 
Published: October 2019

Abstract
We show that the energy conditions are not necessary for boundedness of Riesz transforms in dimension $n\geq 2$. In dimension $n=1$, we construct an elliptic singular integral operator $H_{\flat } $ for which the energy conditions are not necessary for boundedness of $H_{\flat }$. The convolution kernel $K_{\flat }\left ( x\right ) $ of the operator $H_{\flat }$ is a smooth flattened version of the Hilbert transform kernel $K\left ( x\right ) =\frac{1}{x}$ that satisfies ellipticity $ \vert K_{\flat }\left ( x\right ) \vert \gtrsim \frac{1}{\left \vert x\right \vert }$, but not gradient ellipticity $ \vert K_{\flat }^{\prime }\left ( x\right ) \vert \gtrsim \frac{1}{ \vert x \vert ^{2}}$. Indeed the kernel has flat spots where $K_{\flat }^{\prime }\left ( x\right ) =0$ on a family of intervals, but $K_{\flat }^{\prime }\left ( x\right ) $ is otherwise negative on $\mathbb{R}\setminus \left \{ 0\right \} $. On the other hand, if a one-dimensional kernel $K\left ( x,y\right ) $ is both elliptic and gradient elliptic, then the energy conditions are necessary, and so by our theorem in [30], the $T1$ theorem holds for such kernels on the line. This paper includes results from arXiv:16079.06071v3 and arXiv:1801.03706v2.
Endpoint Sobolev Continuity of the Fractional Maximal Function in Higher Dimensions
Authors: Beltran David , Madrid José 
Published: October 2019

Abstract
We establish continuity mapping properties of the noncentered fractional maximal operator $M_{\beta }$ in the endpoint input space $W^{1,1}({\mathbb R}^d)$ for $d \geq 2$ in the cases for which its boundedness is known. More precisely, we prove that for $q=d/(d-\beta )$ the map $f \mapsto |\nabla M_\beta f|$ is continuous from $W^{1,1}({\mathbb R}^d)$ to $L^{q}({\mathbb R}^d)$ for $ 0 &lt; \beta &lt; 1$ if $f$ is radial and for $1 \leq \beta &lt; d$ for general $f$. The results for $1\leq \beta &lt; d$ extend to the centered counterpart $M_\beta ^c$. Moreover, if $d=1$, we show that the conjectured boundedness of that map for $M_\beta ^c$ implies its continuity.
False-Positive Enzymatic Alcohol Results in Perimortem Specimens
Authors: Bishop-Freeman Sandra C , Bertholf Roger L , Powers Robert H , Mayhew Lisa C , Winecker Ruth E 
Published: October 2019

Abstract
Herein, we present 2 cases referred to the North Carolina Office of the Chief Medical Examiner (NC OCME) in which ethanol results reported by different hospital laboratories, using alcohol dehydrogenase (ADH)–based assays, were positive, whereas results of headspace gas chromatography testing performed in the NC OCME laboratory were negative. Literature reports suggest that false-positive ethanol measurements from ADH-based assays can occur when a combination of elevated lactate and lactate dehydrogenase (LD) are present in the specimen. The results were reported in perimortem specimens collected from 2 children with unrelated medical conditions. The cases and associated clinical parameters are considered based on the lactate/LD explanation for the false-positive results, to facilitate the recognition of circumstances that can produce erroneous serum ethanol results.