bluuebunny/crossref_metadata_2025_split huggingface dataset:
A correlation study between cervical cancer and sex hormones
Authors: Wu Xian , You Yitao , Guan Zhichong , Ban Yongpiao , Wang Yiping , Du Dianhua , Wang Bo , Wu Wen , Wen Yue , Ren Yixian , Wu Chunwei , Zhang Xuelin , Mo Lan 
Published: November 2024

ObjectiveThe aims of this study were to investigate the association between positive TCT and sex hormone levels and to evaluate the feasibility of change in sex hormone level as a potential predictor of cervical cancer.MethodsWe recruited 910 female participants from the health examination center of a hospital in Guizhou between 2019 and 2023. All participants had undergone both hematologic examinations and cervical cancer screening.ResultsA total of 265 participants had positive TCT screening. Luteinizing hormone, estradiol, prolactin, and progesterone were negatively correlated with positive TCT screening. Age, systolic blood pressure, alanine aminotransferase, aspartate aminotransferase, urea, fasting blood glucose, low-density lipoprotein, total cholesterol, triglyceride, erythrocyte, follicle-stimulating hormone, and testosterone were positively correlated with positive TCT screening. Logistic regression analysis showed that prolactin, red blood cell count, and age were risk factors for cervical cancer, while FSH was a protective factor for cervical cancer. The AUC of FSH and age in the prediction model was 0.701 and 0.705, respectively.ConclusionThe incidence of cervical cancer increases with increased age and follicle poietin level. At the same time, the increase in FSH level has a certain predictive value for the incidence of cervical cancer.
Case report of kabuki syndrome in a newborn caused by KMT2D gene mutation
Authors: Ba Xuejiao , Yang Xiyao , Zhang Yizhi , Guo Fang , Zhu Lihong , Tong Rui , Yang Yanbin , Qian Yuan , Zhang Hongqing 
Published: November 2024

BackgroundKabuki syndrome is a genetic syndrome that affects multiple organs and systems. Gene mutations are the main cause of KS. Mutations in the KMT2D and KDM6A genes have been reported as two relatively clear pathogenic pathways. This article reports a case of KS with congenital heart disease, hearing abnormalities, and hypoglycemia caused by a KMT2D gene mutation confirmed by clinical exome sequencing, enriching the clinical phenotype and gene mutation spectrum of KS and helping to improve understanding of the disease.Case presentationThrough clinical exome sequencing, we performed genetic diagnosis on a newborn with congenital heart malformation and identified a heterozygous mutation in the KMT2D gene, NM_003482.3:c.4195C&gt;T (p.Gln1399*), which has not been reported as a pathogenic mutation before. This variant was not detected in the peripheral blood of the patient's parents, suggesting it is a de novo mutation.DiscussionKS has strong clinical characteristics and biological heterogeneity. Genetic diagnosis can help identify the types of mutated genes. Our results provide some clues for KS caused by KMT2D gene mutations associated with congenital heart disease, hearing abnormalities, and hypoglycemia. However, the relationship between genotype and phenotype is not yet fully understood. The molecular pathogenesis of KS still needs further exploration and clarification.
Exploring the interplay of information relevance and colorfulness in multimedia learning
Authors: Désiron Juliette C. , Schneider Sascha 
Published: November 2024

IntroductionLooking at recent developments in multimedia learning research, the interaction between cognitive and affective processes is examined more extensively. Based on the emotional design hypothesis, for example, using colors, in contrast to black and white representations, for designing learning materials can elicit positive emotions, guide attention, increase motivation, and foster learning. The attention-guiding effect of colors might not be beneficial when used in learning-irrelevant, decorative pictures. In such a case, the seductive detail effect suggests that interesting but irrelevant additions can hinder learning. Previous studies manipulated colors in the whole learning material independent of the relevance of the information. The present study aimed to examine the effect of color variations according to the relevance of the information presented.MethodsWith a 2 (colorfulness of learning-relevant information background: black and white vs. colored) × 2 (colorfulness of learning-irrelevant pictorial information: black/white vs. colored) between-subject design. The main and interaction effects of colors as attention guides of multimedia learning material on the formation of hurricanes were tested with two samples (128 university students and 140 secondary school students). The first sample is university students in laboratory conditions. The second sample is students in school classes. Besides learning outcomes, perceptions of cognitive load, metacognitive judgments, and affective states are measured.ResultsResults show that the interplay between information relevance and the colorfulness of representations affects learners’ cognitive processes and metacognitive and affective perceptions.DiscussionThese findings have practical implications for the design of multimedia learning materials, highlighting the importance of considering the interplay between colorfulness and information relevance.
Is global health truly global? A hashtag analysis of #GlobalHealth disparities on X
Authors: Arshad Zara , Sharma Pranav , Sharma Shweta , Cheema Mustafa Sajjad , Agarwal Charu , Tango Tamara , Matin Farhan Bin , Atanasov Atanas G. , Siddiquea Bodrun Naher , Matin Maima , Adamska Olga , Stolarczyk Artur , Kashyap Rahul , Nawaz Faisal A. 
Published: November 2024

BackgroundX (Formerly known as Twitter) healthcare hashtags are a popular healthcare informatics and educational tool among medical professionals. #Globalhealth is one such widely used hashtag with extensive engagement. This study analyses #GlobalHealth to understand its pattern, global digital distribution, and other parameters during the COVID-19 pandemic on X.MethodsData was collected by utilizing posts using #GlobalHealth on X from 1st December 2019 to 1st November 2022. The analysis was performed using Symplur Signals to assess several parameters, such as the cumulative number of posts, impressions, category of users, co-occurring hashtags, and geolocation. The Symplur Rank system was used to assess the impact of influencers using the hashtag.ResultsA total of 843,762 posts were shared by 150,408 X users, with 4,639,144,304 impressions. Most posts (73.8%) were made by unclassified accounts, followed by doctors (4.2%), followed by other health workers. The #COVID19 was the most common co-occurring hashtag (43%). The top locations and the most influential X users came from the United States, the United Kingdom, and Canada. Among the top 25 most influential handles, a maximum (N = 09) were based in the United States—most profiles (N = 10) were categorized as international organizations followed by journals (N = 03).ConclusionThe study gives a glimpse into the discrepancies in global distribution and stakeholders of #GlobalHealth. Most posts originated from the global north, which hints at how the trend to #GlobalHealth is not perhaps as global as it is thought to be, and it also reflects upon the real-world scenarios in the context of Global Health Equity. Thus, deeper and wider studies on this digital discrepancy may add more to the existing discourse on the topic.
Family-to-work conflict linked to psychological distress and family life satisfaction during the second year of the COVID-19 pandemic in dual-earner parents with adolescents
Authors: Schnettler Berta , Miranda-Zapata Edgardo , Orellana Ligia , Saracostti Mahia , Poblete Héctor , Concha-Salgado Andrés , Lobos Germán , Adasme-Berríos Cristian , Lapo María , Beroiza Katherine , Riquelme-Segura Leonor , Sepúlveda José A. , Thomas Enid 
Published: November 2024

IntroductionResearch on work-family dynamics during the COVID-19 pandemic shows that family demands increased for workers, particularly those with children. This heightened family-to-work conflict negatively affects the subjective well-being of parents and their children. However, these outcomes have been mainly examined on individuals without considering the family as the unit of analysis. This study aimed to explore the relationships between family-to-work conflict, psychological distress, and family life satisfaction in dual-earner parents with adolescent children during the second year of the COVID-19 pandemic. Moreover, the potential mediating role of psychological distress among FtoWC and family life satisfaction and the moderating role of household monthly income were tested.MethodsThe non-probabilistic sample in Chile comprised 860 dual-earner parents and one of their adolescent children (mean age 13.5 years, 50.8% female). Parents answered an online questionnaire with FtoWC scale, whereas parents and adolescents answered the Depression, Anxiety, Stress Scale and the Satisfaction with Family Life Scale. Analysis was conducted using structural equation modeling and the mediation actor-partner interdependence model.ResultsFtoWC was directly linked to lower family life satisfaction in fathers and via a mediating role of psychological distress in both parents. Mothers’ FtoWC was related via the mediating role of the fathers’ psychological distress to fathers’ lower family life satisfaction and via the mediating role of the adolescents’ psychological distress to adolescents’ lower family life satisfaction. Monthly household income moderated three APIM model paths involving mothers’ variables.DiscussionThese findings underscore the importance of implementing family-oriented workplace policies. Such policies may help mitigate both parents’ experiences of FtoWC and their resulting psychological distress.
Bisphenol A and Its Emergent Substitutes: State of the Art of the Impact of These Plasticizers on Oxidative Stress and Its Role in Vascular Dysfunction
Authors: Palacios-Valladares José R. , Martinez-Jimenez Yesenia I. , Morillon-Torres Vanessa , Rivera-Maya Omar B. , Gómez Rocio , Calderon-Aranda Emma S. 
Published: November 2024

The “One Health approach” has evidenced the significant impact of xenobiotic exposure to health, and humans are a relevant target for their toxic effects. Bisphenol A (BPA) exerts a ubiquitous exposure source in all ecosystems. Given its endocrine-disrupting and harmful consequences on health, several countries have enforced new regulations to reduce exposure to BPA. Cardiovascular diseases (CVDs) are complex conditions that lead to higher mortality worldwide, where family history, lifestyle, and environmental factors, like BPA exposure, have a remarkable contribution. This chemical compound is the most widely used in plastic and epoxy resin manufacturing and has been associated with effects on human health. Therefore, new-generation bisphenols (NGBs) are replacing BPA use, arguing that they do not harm health. Nonetheless, the knowledge about whether NGBs are secure options is scanty. Although BPA’s effects on several organs and systems have been documented, the role of BPA and NGBs in CVDs has yet to be explored. This review’s goals are focused on the processes of endothelial activation (EA)–endothelial dysfunction (ED), a cornerstone of CVDs development, bisphenols’ (BPs) effects on these processes through oxidant and antioxidant system alteration. Despite the scarce evidence on pro-oxidant effects associated with NGBs, our review demonstrated a comparable harmful effect on BPA. The results from the present review suggest that the biological mechanisms to explain BPs cardiotoxic effects are the oxidant stress ↔ inflammatory response ↔ EA ↔ ED → atherosclerotic plate → coagulation promotion. Other effects contributing to CVD development include altered lipid metabolism, ionic channels, and the activation of different intracellular pathways, which contribute to ED perpetuation in a concerted manner.
Effect of Adding Gold Nanoparticles on the Anti-Candidal Activity and Release Profile of Itraconazole from Hydrogels
Authors: Balwierz Radosław , Biernat Paweł , Bursy Dawid , Shanaida Mariia , Kasperkiewicz Katarzyna , Jasińska-Balwierz Agata , Ochędzan-Siodłak Wioletta 
Published: November 2024

Gold nanoparticles have been identified as a promising avenue for the development of drug carriers, particularly in the context of antimicrobial drug delivery, where limited solubility represents a significant challenge. The ability of gold nanoparticles to penetrate biofilms and disrupt fungal cell membranes makes them an effective tool to support antifungal therapy, especially against resistant strains. Gold nanoparticles also demonstrate synergistic effects with chemotherapeutics and can influence the release profile of the active substances. This study aimed to develop a topical hydrogel drug formulation containing itraconazole (ITZ), with the addition of gold nanoparticles, to enhance its therapeutic properties. Due to ITZ’s poor water solubility, three types of the gold nanoparticles (AuNPs) of different sizes were synthesized and subsequently coated with itraconazole. The resulting formulations were incorporated into carbopol gels and their ability to diffuse through semipermeable membranes was assessed. The findings demonstrated that the combination of gold nanoparticles and itraconazole elevated the diffusion coefficient to twice the level observed in gels without nanoparticles. Furthermore, the combined effect of gold nanoparticles and itraconazole against a reference Candida albicans strain was investigated. The combination of gold nanoparticles and itraconazole demonstrated a growth-inhibitory effect on this strain, indicating that this formulation could potentially be employed in the treatment of fungal infections. The study confirms that hydrogels with itraconazole and gold nanoparticles can be obtained, offering enhanced drug diffusion.
Polyphenol content, antioxidant capacity and protein level effects of beetroot and carob-based pre-workout
Authors: Boudoukha Chahra , Amor Loubna , Nouioua Wafa , Daif Amina Selsabil , Belhattab Rachid 
Published: November 2024

The present study aimed to asses the effect of mixing beet root (Beta vulgaris L) and carob (Ceratonia siliqua) on the antioxidant capacity and the protein level in the pre-workout. We procced to use the distilled water to extract the pre-workout powder, Spectrophotometry technique was employed to assess the total phenol content and protein level using the Folin-Ciocalteu test, and Bradford method respectively , Flavonoids were quantified using UV-Visible spectrometry in the presence of aluminum trichloride (AlCl3). For the antioxidant capacity, anti-radical activity (DPPH test), assay of total antioxidant capacity (CAT) and potassium ferricyanide reducing power test (FRAP) were used. It is observed that the yield of the aqueous extract was found to be 10%. The concentration of polyphenols in the aqueous extract was estimated at 224.8 ± 31.88 µg EAG/mg E, while the flavonoid content was measured at 1.84 ± 0.90 µg EQ/mg E. The IC50 value obtained from the DPPH test was 313.07 μg/ml. Additionally, the CAT and FRAP assays indicated values of 55% and an EC50 of 249.859 μg/ml, respectively. Furthermore, the extract contained a protein concentration of 11.90 ± 0.143 g per 100 g of dry weight. In conclusion, aqueous extract is high in phenol and flavonoids, and demonstrated a significant antioxidant capacity. The high protein level makes it a great choice for athletes.
СТРУКТУРА І ЗМІСТ ГОТОВНОСТІ ВИКЛАДАЧА ЗВО ДО РЕАЛІЗАЦІЇ ЗМІШАНОГО НАВЧАННЯ: ТЕОРЕТИЧНО-ЕКСПЕРИМЕНТАЛЬНИЙ ДИСКУРС
Authors: Лук’янова Лариса 
Published: November 2024

У статті здійснено аналіз наукових поглядів щодо визначення феномену готовності викладачів ЗВО до професійної діяльності, зокрема у контексті його готовності до реалізації змішаного навчання. Проаналізовано ступінь дослідженості понять готовність і змішане навчання. Визначено сутність поняття та обґрунтовано структуру готовності викладачів ЗВО до реалізації змішаного навчання. На основі експериментального дискурсу обґрунтовано актуальність досліджуваного явища в освітній практиці через сукупність чинників, детермінованих стрімкими темпами модернізації усіх компонентів освіти на засадах випереджувального розвитку, осучасненням професійних функцій викладача ЗВО як суб’єкта освітньої діяльності, нагальною потребою безперервного удосконалення професійної компетентності викладача. Доведено, що сутнiсть готовностi викладачів ЗВО до відповідного виду професійної діяльності слід розглядати у дiалектичнiй єдностi її структурних компонентiв, властивостей, зв’язкiв i вiдносин, сукупність яких складає інваріантні та іманентні складові у поєднанні особистісного та процесуального складників. Основу структури досліджуваного явища складають три взаємопов’язані компоненти готовності (психологічна, методична і технологічна), зміст яких наповнюють 13 обґрунтованих взаємообумовлених показників (психологічна готовність: мотиваційний; предметний; рефлексивний; адаптивний; методична готовність: інформаційний; методичний; емпіричний; змістовий; технологічна готовність: технологічні знання; технологічні уміння; цифровий; діяльнісний; комплексний), які мають вияв на трьох рівнях.
PENGARUH VIDEO EDUKASI VIRTUAL TOUR INSTALASI BEDAH SENTRAL (IBS) TERHADAP KECEMASAN MAHASISWA KEPERAWATAN ANESTESIOLOGI UNIVERSITAS ‘AISYIYAH YOGYAKARTA DALAM MENGHADAPI PRAKTIK KLINIK DI IBS
Authors: Sahid Irfan Nur , Purnamasari Vita , Handayani Nia 
Published: November 2024

Latar belakang: Mahasiswa Keperawatan Anestesiologi rentan mengalami kecemasan saat praktik klinik di IBS karena kurangnya pengalaman dan pengetahuan tentang lingkungan. Oleh karena itu, diperlukan pendekatan pendidikan kesehatan untuk mengurangi kecemasan dan mempersiapkan mereka lebih baik dalam praktik klinik.Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh video edukasi virtual tour Instalasi Bedah Sentral (IBS) terhadap kecemasan Mahasiswa Keperawatan Anestesiologi Universitas ‘Aisyiyah Yogyakarta dalam menghadapi praktik klinik di IBS.Metode: Metode dalam penelitian ini adalah metode kuantitatif. Desain penelitian Pre-eksperimental dengan pendekatan One Group Pretest-Posttest Design. Teknik pengambilan sampel yaitu simple random sampling yang berjumlah 64 responden sesuai dengan kriteria inklusi dan ekslusi. Analisis data dalam penelitian ini menggunakan uji wilcoxon signed test.Hasil: Hasil uji wilcoxon signed test didapatkan nilai p-value sebesar 0,000 (p<0,05) sehingga H0 ditolak H1 diterima.Kesimpulan: Terdapat pengaruh video edukasi virtual tour IBS terhadap kecemasan Mahasiswa Keperawatan Anestesiologi dalam menghadapi praktik klinik di Instalasi Bedah Sentral. Kata kunci : Kecemasan, Video Edukasi, Praktik Klinik
THE RELATIONSHIP OF FAMILY KNOWLEDGE WITH THE ROLE OF DECISION MAKING SUPPORT IN CARE OF CRITICAL PATIENTS IN THE ICU OF PKU MUHAMMADIYAH BANTUL HOSPITAL
Authors: Pratiwi Elsa Aulya , Azizah Aisyah Nur 
Published: November 2024

Background: ICU patients are generally in life-threatening conditions, these conditions make patients unable to make decisions about themselves, family involvement in this condition is in the form of providing verbal, non-verbal information, advice, real assistance from people they know such as partners, parents, or other family members, accompanying sick family members, families must be able to recognize family health problems, make the right decisions where this is based on the knowledge of family members.Objective: This study aims to determine the relationship between family knowledge and the role of decision-making in critical care patients in the ICU. Method: This type of research is quantitative research with a cross-sectional research design. The sampling technique used accidental sampling totaling 52 respondents with inclusion and exclusion criteria. Data analysis was carried out using Kendall's correlation.Results: From 52 respondents, 36 respondents (69%) had good knowledge about ICU, and 16 respondents (31%) had poor knowledge about ICU. Good decision- making support was obtained for 31 respondents (60%), sufficient for 6 respondents (11%), and lacking for 15 respondents (29%). The results of the Kendall Tau correlation test to determine the relationship between family knowledge about ICU and support for decision-making in critical patient care in ICU were 0.010 (<0.05), which means there is a significant relationship between the independent variable and the dependent variable.Conclusion: There was a significant relationship between family knowledge and the role of decision-making in critical care in the ICU.Suggestion: Further research is needed comparing the level of decision-making support based on different emergencies. Keyword : Decision Making, Family Knowledge, critical care
HUBUNGAN STRES DAN POLA MAKAN TERHADAP KEKAMBUHAN PENDERITA GASTRITIS DI UPTD PUSKESMAS WIROSARI 1
Authors: Indriani Eva , Suryani Suryani , Widayati Christina Nur , Temu Sri 
Published: November 2024

Latar Belakang: Gastritis yang secara umum dikenal sebagai penyakit tidak menular yang sering didengar dalam kehidupan sehari-hari. Penyakit ini masih dianggap sepele karena kurangnya kepekaan Masyarakat terhadap dampak dari penyakit ini. Penyakit gastritis dapat membbuat seseorang meninggal jika penyakit tersebut sudah akut. Banyak faktor yang menyebabkan kejadian gastritis. Adapun faktor yang menyebabkan gastritis antara lain mengkonsumsi asetaminofen, selain itu aktifitas fisik, kebiasaan merokok, minum kopi, mengkonsumsi alkohol, stres dan pola makan juga dapat memicu gastritis.Tujuan: Untuk mengetahui Hubungan Stres Dan Pola Makan Terhadap Kekambuhan Penderita Gastritis Di UPTD Puskesmas Wirosari 1.Metode: Pada penelitian ini menggunakan jenis penelitian kuantitatif dengan menggunakan metode penelitian case control dengan menggunakan pendekatan retrospective. Hasil: Hasil uji chi square, stres diperoleh hasil bahwa p value = 0,000 < ? (0,05) dan yang berarti Ha diterima dan H0 ditolak, oods ratio 9. 730 dan hasil uji chi square pola makan diperoleh hasil bahwa p value = 0,000 < ? (0,05) yang berarti Ha diterima dan H0 ditolak, odds ratio 0,154.Kesimpulan: Ada hubungan stres terhadap kekambuhan penderita gastritis di UPTD Puskesmas Wirosari 1 dan ada hubungan pola makan terhadap kekambuhan penderita gastritis di UPTD Puskesmas Wirosari 1.Kata Kunci: Stres, Pola Makan, GastritisKepustakaan: 61 (2010-2023)
PENGARUH SENAM JANTUNG SEHAT TERHADAP TEKANAN DARAH PADA PENDERITA HIPERTENSI DI PUSKESMAS SUMBERLAWANG
Authors: Rahmawati Rahmawati , Lufianti Anita , Yuwanti Yuwanti 
Published: November 2024

Latar belakang: Hipertensi terjadi saat aliran darah jantung sangat kuat sehingga menekan dinding arteri dengan kuat. Apabila tekanan darah seseorang ?140/90 mmHg dikatakan menderita hipertensi.angka kejadian hipertensi di Puskesmas Sumberlawang pada tahun 2022 sebanyak 3.101 kasus dan terjadi peningkatan pada tahun 2023 yaitu sebanyak 6.357 kasus.Tujuan penelitian ini adalah mengetahui pengaruh senam jantung sehat terhadap tekanan darah pada penderita hipertensi di Puskesmas Sumberlawang. Metodologi: Menggunakan jenis penelitian kuantitatif dengan teknik Quasi Eksperimen dengan One Group Pretest-Posttest. Jumlah total sampel adalah 18 responden penderita hipertensi di Puskesmas Sumberlawang teknik pengambilan sampel menggunakan random sampling. Hasil: Hasil analisis statistik dari uji Paired t-Test di dapatkan tekanan darah sistol ? value ,000 ? 0,05 yang artinya H0 ditolak Ha diterima, dapat disimpulkan ada pengaruh senam jantung sehat terhadap tekanan darah pada penderita hipertensi di Puskesmas Sumberlawang. Kesimpulan: Berdasarkan dari penelitian ini ada pengaruh senam jantung sehat terhadap teknan darah pada penderita hipertensi di Puskesmas Sumberlawang. Diharapkan bagi lansia penderita hipertensi. Latihan senam ini dapat dilakukan sebagai terapi non farmakologi untuk menurunkan tekanan darah . Kata kunci: senam jantung sehat, tekanan darahKepustakaan: ( 2013-2023)