bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double‐Blind, Placebo‐Controlled, Multicenter Trial
Authors: Yarnitsky David , Dodick David W. , Grosberg Brian M. , Burstein Rami , Ironi Alon , Harris Dagan , Lin Tamar , Silberstein Stephen D. 
Published: May 2019

ObjectiveTo assess the efficacy and safety of a remote electrical neuromodulation (REN) device for the acute treatment of migraine.BackgroundThere is a significant unmet need for novel effective well‐tolerated acute migraine treatments. REN is a novel acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation – an endogenous analgesic mechanism in which conditioning stimulation inhibits pain in remote body regions. A recent pilot study showed that REN can significantly reduce headache. We have conducted a randomized, double‐blind, sham‐controlled study to further evaluate the efficacy and safety of REN for the acute treatment of migraine.MethodsThis was a randomized, double‐blind, sham‐controlled, multicenter study conducted at 7 sites in the United States and 5 sites in Israel. Two hundred and fifty‐two adults meeting the International Classification of Headache Disorders criteria for migraine with 2‐8 migraine headaches per month were randomized in a 1:1 ratio to active or sham stimulation. A smartphone‐controlled wireless device was applied for 30‐45 minutes on the upper arm within 1 hour of attack onset; electrical stimulation was at a perceptible but non‐painful intensity level. Migraine pain levels were recorded at baseline, 2, and 48 hours post‐treatment. Most bothersome symptoms (MBS) were also recorded. The primary efficacy endpoint was the proportion of participants achieving pain relief at 2 hours post‐treatment (improvement from severe or moderate pain to mild or none, or from mild pain to none). Relief of MBS and pain‐free at 2 hours were key secondary endpoints.ResultsActive stimulation was more effective than sham stimulation in achieving pain relief (66.7% [66/99] vs 38.8% [40/103]; therapeutic gain of 27.9% [CI95%, 15.6‐40.2];P< .0001), pain‐free (37.4% vs 18.4%,P= .003), and MBS relief (46.3% vs 22.2%,P= .0008) at 2 hours post‐treatment. The pain relief and pain‐free superiority of the active treatment was sustained 48 hours post‐treatment. The incidence of device‐related adverse events was low and similar between treatment groups (4.8% [6/126] vs 2.4% [3/126],P= .499).ConclusionsREN provides superior clinically meaningful relief of migraine pain and MBS compared to placebo, offering a safe and effective non‐pharmacological alternative for acute migraine treatment.
Basal cell carcinoma of the groin and buttocks: a clinical and histological analysis of a rare presentation of a common tumor
Authors: Tidwell W. James , Sutton Adam , Gilbertson Ryan , Humberson Cora , Greenway Hubert 
Published: May 2019

AbstractBackgroundBasal cell carcinoma (BCC) is a common tumor but rarely presents on nonexposed skin. We sought to identify and characterize the traits of the malignancy over a 10‐year period.MethodsA retrospective chart review of all BCCs between 2007 and 2017 was performed. Clinical characteristics and histological features were evaluated.ResultsOf all BCCs biopsied in a 10‐year period, 53 tumors in 50 patients were diagnosed in the groin or buttocks. This accounts for 0.094% of all BCCs during this time period. None of the cases had genetic diseases prone to skin cancer development or were immunosuppressed. The most common location was the buttocks, and the most frequently diagnosed histological subtype was nodular (49%).ConclusionTo our knowledge, this is the largest report of BCC of the groin and buttocks. In this rare presentation of a common tumor, the histological characteristics of it are not more aggressive than other sites on the body.
A series of 33 older patients with lip venous lake treated by sclerotherapy
Authors: Fernandes Diego Tetzner , Hebling Eduardo , Santos‐Silva Alan Roger , Lopes Márcio Ajudarte 
Published: May 2019

AbstractBackgroundVenous lake lesion is a venous ectasia that can occur on the lips of older people. Although different therapies have been used, there is no guideline for treating this lesion. The purpose of this study was to evaluate whether sclerotherapy is an effective and acceptable option for treatment of venous lake lesions of the lips in older patients.MethodsMedical records and images were retrieved from the archives of a geriatric dentistry clinic between 2005 and 2017. A total of 33 older patients treated with 5% ethanolamine oleate were included. Clinical information was selected and described.ResultsThe female gender was predominant (64%), and the patients’ age ranged from 66 to 90 years. The majority of the patients were Caucasian (91%), and 82% were under treatment for hypertension. In 91% of the cases, the lesions were located on the lower lip and varied from 3 to 10 mm in diameter. A complaint period lasting longer than 2 years was reported by 58% of the patients. Color alteration was the most common type of esthetic complaint. Only one application of sclerotherapy was performed in 85% of the cases. For the remaining patients, two sessions were necessary. The total dose ranged from 0.3 to 0.9 ml. Complete regression of the lesions was observed in all cases. No complications or recurrences were reported.ConclusionSclerotherapy with ethanolamine oleate is an effective, affordable, and predictable treatment for venous lake lesions of the lips in older patients.
Uncertainty assessment of soya bean yield gaps using DSSAT‐CSM‐CROPGRO‐Soybean calibrated by cultivar maturity groups
Authors: Teixeira Wilson Wagner Ribeiro , Battisti Rafael , Sentelhas Paulo Cesar , de Moraes Milton Ferreira , de Oliveira Junior Adilson 
Published: May 2019

AbstractSoya bean yield gap can be caused by different factors resulting in uncertainties when the objective is to use such information for farm decision‐making and reference yield determination. Thus, this study aimed to quantify the soya bean yield gap for four sites, located in Southern and Midwestern Brazil, as well as the uncertainties of that related to cultivars, sowing dates, soil types and reference yields. The crop simulation model DSSAT‐CSM‐CROPGRO‐Soybean was calibrated for cultivars with similar maturity groups, based on the data obtained from the best farmers at the county level. The yield gap by water deficit (YGWD) was obtained through the difference between potential and attainable yields, and that one caused by sub‐optimum crop management (YGCM) by subtracting actual yield of each county, obtained from official statistics between 1989/90 and 2014/15 growing seasons, from the estimated attainable yield. The yield was simulated using four sowing dates, three soil types and two soya bean maturity groups by county. The reference yield uncertainty was quantified using yield reference from crop model and regional winners of the soya bean yield context, conducted by CESB (Brazilian Soybean Strategic Committee), for the growing seasons from 2013/14 to 2015/16. The crop model showed a good agreement between measured and simulated crop development and growth using calibration by maturity group, with low root mean square error (347 kg/ha). Southern sites had a mean YGWD of 1,047 kg/ha, while in the Midwest, it was lower than 100 kg/ha. The YGCM was 1,067, 528, 984 and 848 kg/ha, respectively, for Castro, PR, Mamborê, PR, Montividiu, GO and Primavera do Leste, MT, representing the opportunity for yield gain when having the best farmers as reference. The maturity groups, sowing dates and soil types showed to be an important source of uncertainty for yield gap determination, being recommended to investigate the farms in detail for an appropriate quantification. The reference yield showed expressive uncertainties, with some farmers presenting conditions to increase their soya bean yields by more than 3,000 kg/ha, when considering as reference the yields obtained by the winners’ farmers. These results show that uncertainties must be reduced when assessing farm yield gaps, in order to ensure that expected rate of soya bean yield growth could be reached by adopting the same technologies from CESB winners and best farmers in the county as a reference.
Systematic Review: Expressive arts interventions to address psychosocial stress in healthcare workers
Authors: Phillips Carolyn S. , Becker Heather 
Published: May 2019

AbstractAimsTo synthesize evidence about the effectiveness of expressive arts interventions used to reduce psychosocial stress among healthcare workers.DesignQuantitative systematic review following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.Data SourcesSocINDEX, PsycINFO, Pubmed, CINAHL.Review MethodsDatabases were searched from 1997–2017. Fourteen studies met the criteria for final selection.ResultsMost studies occurred in the US (N = 11). Of the 897 participants, 59% were nurses. Two studies were randomized controlled trials and the others were a variation of a 1‐group or 2‐group pre‐ or quasi‐experimental study. The intervention characteristics included 50% art‐based, 29% music‐based, and 21% used storytelling or narrative. The length of intervention varied from 1 hr to 13 weeks; 5 lasted 6 weeks. Improved outcomes were found in 13 of 14 studies reviewed and the greatest improvements were seen in burnout, stress, and emotional outcomes. Overall, music and art‐based interventions had greater impact on well‐being than storytelling or narrative.ConclusionsThis systematic review provides preliminary evidence for the effectiveness of expressive arts interventions.ImpactCare for others is a preeminent value in health care; however, this can come at the expense of caring for oneself. Psychosocial stress poses a significant threat to the well‐being of the healthcare workforce. Expressive arts interventions provide a creative means for reducing caregiver stress to remain well and able to provide high quality care to patients. The use of arts for healing has global application because expressive arts intervention can be culturally tailored and relevant.
A scale for measuring evidence‐searching capability: A development and validation study
Authors: Tsai Yu‐Shiun , Fang Tien‐Pei , Chi Ching‐Chi 
Published: May 2019

AbstractRationaleThe ability to acquire the best evidence efficiently is an important competency for busy health‐care professionals who must make decisions quickly.Aims and objectivesWe aimed to develop and validate a scale for measuring evidence‐searching capability.MethodsWe first developed a scale for measuring evidence‐searching capability by using the modified Delphi technique. Seven experts commented on a draft 33‐item scale on a 5‐point scale. All items rated less than three by any expert were removed. The items were modified or merged considering experts' feedback. When all items were rated greater than or equal to 3 by all experts with an interquartile range of less than or equal to 1, a consensus on the scale was achieved with the content validity constructed. We performed a pilot test and a formal test, and evaluated the inter­rater, intra‐rater, and internal reliability by calculating the intra‐cluster correlation coefficient (ICC), kappa correlation coefficient, and Cronbach's α.ResultsWe developed a scale consisted of 15 items and a global rating score, with an average scale‐content validity index of 0.98. In the pilot test, the ICC for inter‐rater and intra‐rater reliability was 0.91 and 1, respectively. The Cronbach's α was 0.90. In the formal test, the ICC for inter‐rater reliability ranged from 0.61 to 1 and the weighted kappa correlation coefficient ranged from 0.27 to 1, with a Cronbach's α of 0.97.ConclusionsThis study is the first to develop and validate a scale for measuring evidence‐searching skills through a systematic approach. The scale is composed of 15 items and a global rating score that can be easily used in objective assessment of knowledge‐acquiring ability.
Label‐free distribution of anti‐amyloid D‐AIP in Drosophila melanogaster: prevention of Aβ42‐induced toxicity without side effects in transgenic flies
Authors: Zhong Yifei , Shobo Adeola , Hancock Mark A. , Multhaup Gerhard 
Published: May 2019

AbstractSoluble oligomers of the 42‐amino acid amyloid beta (Aβ42) peptide are highly toxic and suspected as the causative agent of synaptic dysfunction and neuronal loss in Alzheimer's disease (AD). Previously, we have shown that a small, D‐amino acid Aβ42‐oligomer interacting peptide (D‐AIP) can neutralize human Aβ42‐mediated toxicity using in vitro and cell‐based assays. In the present longitudinal study using a transgenic Drosophila melanogaster model, advanced live confocal imaging and mass spectrometry imaging (MALDI‐MSI) showed that the eight amino acid D‐AIP can attenuate Aβ42‐induced toxicity in vivo. By separating male and female flies into distinct groups, the resultant distribution of ingested D‐AIP was different between the sexes. The Aβ42‐induced ‘rough eye’ phenotype could be rescued in the female transgenics, likely because of the co‐localization of D‐AIP with human Aβ42 in the female fly heads. Interestingly, the phenotype could not be rescued in the male transgenics, likely because of the co‐localization of D‐AIP with a confounding male‐specific sex peptide (Acp70A candidate in MSI spectra) in the gut of the male flies. As a novel, more cost‐effective strategy to prevent toxic amyloid formation during the early stages of AD (i.e. neutralization of toxic low‐order Aβ42 oligomers without creating larger aggregates in the process), our longitudinal study establishes that D‐AIP is a stable and highly effective neutralizer of toxic Aβ42 peptides in vivo.
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Cover Image for this issue: doi: 10.1111/jnc.14512.
Hysteroscopic morphological pattern reflects histological grade of endometrial cancer
Authors: Miyamoto Taito , Abiko Kaoru , Murakami Ryusuke , Furutake Yoko , Baba Tsukasa , Horie Akihito , Hamanishi Junzo , Mandai Masaki 
Published: May 2019

AbstractAimTo examine the hysteroscopic morphological features in each histological grade of endometrial cancer, and to distinguish high‐ and low‐grade cancer and low‐grade cancer and atypical endometrial hyperplasia (AEH), using hysteroscopy.MethodsIn total, 135 patients who underwent hysterectomy after hysteroscopy were analyzed. They were divided into four categories: benign lesion; AEH; low‐grade cancer, including endometrioid carcinoma grades 1 and 2 (G1/2); and high‐grade cancer, including endometrioid carcinoma grade 3 and other high‐grade carcinomas (G3/others). Three blinded gynecologic oncologists independently evaluated hysteroscopic video images for abnormal vessels, surface smoothness, papillary structure and polypoid structure. Prevalence rates of each finding were compared between the four categories. The accuracy of blind biopsy in outpatient settings and hysteroscopic endometrial biopsy in the four categories were also investigated.ResultsThe number of patients with benign lesions, AEH, G1/2 and G3/others was 8, 7, 84 and 36, respectively. Patients with G3/others exhibited more polypoid (86% vs 61%, P = 0.0095) and less papillary (59% vs 80%, P = 0.023) structures than those exhibited by patients with G1/2. AEH and G1/2 were indistinguishable using hysteroscopy. Hysteroscopic biopsy was more accurate than outpatient biopsy in patients with G3/others (84% vs 52%, respectively, P = 0.010). Both biopsies were not sufficiently accurate to diagnose AEH (outpatient; 0%, hysteroscopic; 57%).ConclusionHysteroscopic papillary and polypoid structures can help distinguish between high‐ and low‐grade cancer. Hysteroscopic differentiation between AEH and low‐grade cancer is difficult. These findings are considerable in preoperative assessment to determine adequate surgical strategies.
Uterine cervical ulceration caused by group C streptococcal infection during pregnancy: A case report
Authors: Yoon Soonna , Tsubouchi Hiroaki , Tsunehiro Azusa , Ohyagi Chifumi , Fukuda Aya , Tsutsui Tateki 
Published: May 2019

AbstractCauses of cervical ulceration include infection, collagen disease, malignant tumors and external stimuli. Cervical ulceration during pregnancy is rare. We present a case of cervical ulceration caused by group C streptococcal infection during pregnancy. A 36‐year‐old woman (gravida 1, para 0) complained of metrorrhagia, and a circular cervical ulcer of about 1.5 cm in diameter was detected on her cervix at 37 weeks' gestation. A biopsy and a cultivation test of the ulcer were performed, and pathological diagnosis was made as suppurative inflammation, and group C streptococcal infection was detected by the cultivation test. The ulcer had expanded to about 3 cm in diameter at the onset of labor at 40 weeks' gestation. An emergency cesarean section was performed because of failed induction of labor, and she was delivered of a male baby. The ulcer became gradually smaller after delivery, and completely disappeared on the 35th day after delivery.
Conservative management in hypertriglyceridemia‐associated pancreatitis
Authors: Berberich A. J. , Ziada A. , Zou G. Y. , Hegele R. A. 
Published: May 2019

AbstractBackgroundSevere hypertriglyceridemia (serum triglyceride >10 mmol L−1) is implicated in ~9% of acute pancreatitis cases. Certain guidelines list severe hypertriglyceridemia as an indication for plasmapheresis.ObjectiveWe assembled the natural trajectory of triglyceride levels in patients with acute pancreatitis due to severe hypertriglyceridemia who were managed conservatively without plasmapheresis to evaluate the effectiveness of this approach.MethodsA retrospective chart review was performed on 22 hospital admissions for acute pancreatitis episodes considered to be caused by severe hypertriglyceridemia. Patients were managed supportively, with cessation of oral intake (NPO) and intravenous hydration. Insulin infusion was used in 12 patients to manage concurrent hyperglycaemia.ResultsTriglyceride levels for the group were evaluated using a mixed‐effects model. The average triglyceride level fell from 45.4 mmol L−1 on presentation to 13.3 mmol L−1 within 48 h, corresponding to a mean 69.8% decrease. Regression analysis showed a triglyceride half‐life of 30.6 h. Findings were similar for NPO‐only and insulin infusion subgroups.ConclusionPatients with severe hypertriglyceridemia and acute pancreatitis can be conservatively managed safely and effectively without plasmapheresis.
Aging and Brain Atrophy in Multiple Sclerosis
Authors: Ghione Emanuele , Bergsland Niels , Dwyer Michael G. , Hagemeier Jesper , Jakimovski Dejan , Paunkoski Ivo , Ramasamy Deepa P. , Carl Ellen , Hojnacki David , Kolb Channa , Weinstock‐Guttman Bianca , Zivadinov Robert 
Published: May 2019

ABSTRACTBACKGROUND AND PURPOSEBrain atrophy accelerates at the age of 60 in healthy individuals (HI) and at disease onset in multiple sclerosis (MS) patients. Whether there is an exacerbating effect of aging superimposed on MS‐related brain atrophy is unknown. We estimated the aging effect on lateral ventricular volume (LVV) and whole brain volume (WBV) changes in MS patients.METHODS1,982 MS patients (mean follow‐up: 4.8 years) and 351 HI (mean follow‐up: of 3.1 years), aged from 20 to 79 years old (yo), were collected retrospectively. Percent LVV change (PLVVC) and percent brain volume change (PBVC) on 1.5T and 3T MRI scanners (median of 3.9 scans per subject) were calculated. These were determined between all‐time points and subjects were divided in six‐decade age groups. MRI differences between age groups were calculated using analysis of covariance (ANCOVA).RESULTSCompared to HI, at first MRI, MS patients had significantly increased LVV in the age groups: 30–39 yo, 40–49 yo, 50–59 yo, 60–69 yo (all P < .0001), and 70–79 yo (P = .029), and decreased WBV in the age groups: 20–29 yo (P = .024), 30–39 yo (P = .031), 40–49 yo, and 50–59 yo (all P < .0001). Annualized PLVVC was significantly different between the age groups 20–59 and 60–79 yo in MS patients (P = .005) and HI (P < .0001), as was for PBVC in MS patients (P = .001), but not for HI (P = .521). There was a significant aging interaction effect in the annualized PLVVC (P = .001) between HI and MS patients, which was not observed for the annualized PBVC (P = .380).CONCLUSIONSDevelopment of brain atrophy manifests progressively in MS patients, and occurs with a different pattern, as compared to aging HI. PLVVC increased across age in HI as compared to MS, while PBVC decreased across ages in both HI and MS.
Patients’ experiences of therapeutic jaw exercises in the treatment of masticatory myofascial pain—A postal questionnaire study
Authors: Lindfors Erik , Magnusson Tomas , Ernberg Malin 
Published: May 2019

AbstractBackgroundThe most common non‐dental pain in the orofacial region is pain associated with temporomandibular disorders (TMD), and jaw exercises are a common treatment in these cases. Since masticatory myofascial pain has components of an affective and cognitive nature, knowledge about the patients’ experiences of the condition and treatment is important.ObjectiveThe aim was to study the patients’ experiences of jaw exercises in the treatment of masticatory myofascial pain.MethodsA questionnaire, containing 24 statements that should be answered according to a five‐item verbal Likert scale, was sent to 150 consecutive patients with masticatory myofascial pain according to the Research Diagnostic Criteria for TMD after they had been treated with jaw exercises for 3‐12 months.ResultsThe response rate was 73% (n = 109), and 79% of the responders were women. 71% of the patients reported that it was easier to remember the jaw exercises if they put them in conjunction with an already established routine. Before examination, 49% of the patients suspected serious disease behind their symptoms, but these concerns were greatly relieved by the information provided. As a result, 78% reported that information about the underlying cause of their symptoms made them more involved in the treatment. Finally, 72% of the respondents reported that the jaw exercises were effective in reducing their symptoms.ConclusionsInformation about the cause of the symptoms and the treatment is important to reassure and make the patient involved in the treatment. Most patients report that jaw exercises are an effective treatment and they appreciated to have tools to tackle the problems themselves if the symptoms should return.