bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Serological Associations with the Development of Incident Proteinuria in Danish Patients with Systemic Lupus Erythematosus
Authors: Tanha Nima , Hansen Renata Baronaite , Nielsen Christoffer Tandrup , Faurschou Mikkel , Jacobsen Søren 
Published: April 2018

Objective.In a longitudinal cohort study, we investigated whether clinical and serological manifestations at the time of classification of systemic lupus erythematosus (SLE) were predictive of subsequent development of incident proteinuria as a biomarker of incident lupus nephritis.Methods.Patients fulfilling SLE classification criteria but having no proteinuria prior to or at the time of classification were included. Data on SLE manifestations, vital status, criteria-related autoantibodies, and SLE-associated medications were collected during clinical visits and supplemented by chart review. HR were calculated by Cox regression analyses.Results.Out of 850 patients with SLE, 604 had not developed proteinuria at the time of SLE classification. Of these 604 patients, 184 (30%) developed incident proteinuria following SLE classification. The patients had a median followup of 11 years and 7 months. Younger age and history of psychosis at the time of classification were associated with development of incident proteinuria, just as were lymphopenia (HR 1.49, 95% CI 1.08–2.06), anti-dsDNA (HR 1.38, 95% CI 1.01–1.87), and a high number of autoantibodies (HR 1.26, 95% CI 1.06–1.48).Conclusion.The risk of incident proteinuria after onset of SLE was increased by the presence of lymphopenia, anti-dsDNA antibodies, psychosis, younger age, and a high number of autoantibodies at onset.
Macrophage Activation Syndrome in Patients Affected by Adult-onset Still Disease: Analysis of Survival Rates and Predictive Factors in the Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale Cohort
Authors: Ruscitti Piero , Iacono Daniela , Ciccia Francesco , Emmi Giacomo , Cipriani Paola , Grembiale Rosa Daniela , Perosa Federico , Emmi Lorenzo , Triolo Giovanni , Giacomelli Roberto , Valentini Gabriele 
Published: April 2018

Objective.Macrophage activation syndrome (MAS) is a reactive form of hemophagocytic lymphohistiocytosis, which can complicate adult-onset Still disease (AOSD). We investigated AOSD clinical features at the time of diagnosis, to assess predictors of MAS occurrence. Further, we analyzed the outcomes of patients with AOSD who experience MAS.Methods.Patients with AOSD admitted to any Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale center were retrospectively analyzed for features typical of AOSD, MAS occurrence, and their survival rate.Results.Of 119 patients with AOSD, 17 experienced MAS (12 at admission and 5 during followup). Twelve patients with MAS at first admission differed from the remaining 107 in prevalence of lymphadenopathy and liver involvement at the time of diagnosis. In addition, serum ferritin levels and systemic score values were significantly higher in the patients presenting with MAS. At the time of diagnosis, the 5 patients who developed MAS differed from the remaining 102 in the prevalence of abdominal pain, and they showed increased systemic score values. In the multivariate analysis, lymphadenopathy (OR 7.22, 95% CI 1.49–34.97, p = 0.014) and abdominal pain (OR 4.36, 95% CI 1.24–15.39, p = 0.022) were predictive of MAS occurrence. Finally, MAS occurrence significantly reduced the survival rate of patients with AOSD (p < 0.0001).Conclusion.MAS occurrence significantly reduced the survival rate in patients with AOSD. Patients with MAS at baseline presented an increased prevalence of lymphadenopathy and liver involvement, as well as high serum ferritin levels and systemic score values. The presence of lymphadenopathy and abdominal pain was associated with MAS occurrence.
Association of Serum Soluble CD163 with Polymyositis and Dermatomyositis, Especially in Anti-MDA5 Antibody–positive Cases
Authors: Kawasumi Hidenaga , Katsumata Yasuhiro , Nishino Akira , Hirahara Shinya , Kawaguchi Yasushi , Kuwana Masataka , Yamanaka Hisashi 
Published: April 2018

Objective.We elucidated the association of serum soluble CD163 (sCD163) with rapidly progressive interstitial lung disease (RP-ILD), autoantibody profiles, and serum ferritin in patients with polymyositis (PM), classic dermatomyositis (DM), and clinical amyopathic dermatomyositis (CADM).Methods.Serum sCD163 levels were retrospectively measured by ELISA in patients with PM, classic DM, and CADM, as well as in healthy controls (HC). Repeat sera samples were obtained posttreatment from available patients. The associations between serum sCD163 levels and clinical information were analyzed.Results.Serum sCD163 levels in patients with PM/classic DM/CADM were significantly higher than those in HC (n = 72, 56, 34, and 68, respectively; p < 0.001 for all comparisons). No significant difference was observed between serum sCD163 levels in patients with and without ILD (p = 0.16) or between those with RP-ILD and chronic ILD (p = 0.21). Serum sCD163 levels were significantly higher in patients with anti-MDA5 antibodies (n = 27) than in those without (p = 0.001). Serum sCD163 levels were weakly correlated with serum ferritin levels in the patients with PM, classic DM, and CADM (r = 0.21). Serum sCD163 levels decreased significantly following treatment in all patient groups (p = 0.003).Conclusion.The present results suggest an association of serum sCD163 with PM, classic DM, and CADM, especially in anti-MDA5 antibody–positive cases. However, serum sCD163 levels were not specifically associated with ILD or RP-ILD.
Longterm Safety and Efficacy of Adalimumab and Infliximab for Uveitis Associated with Juvenile Idiopathic Arthritis
Authors: Cecchin Vanessa , Zannin Maria Elisabetta , Ferrari Daniele , Pontikaki Irene , Miserocchi Elisabetta , Paroli Maria P. , Bracaglia Claudia , Marafon Denise Pires , Pastore Serena , Parentin Fulvio , Simonini Gabriele , De Libero Cinzia , Falcini Fernanda , Petaccia Antonella , Filocamo Giovanni , De Marco Riccardo , La Torre Francesco , Guerriero Silvana , Martino Silvana , Comacchio Francesco , Muratore Valentina , Martini Giorgia , Vittadello Fabio , Zulian Francesco 
Published: April 2018

Objective.Anti-TNF-α agents have significantly changed the management of juvenile idiopathic arthritis (JIA). We evaluated the safety and efficacy of adalimumab (ADA) and infliximab (IFX) for the treatment of JIA-associated uveitis in patients treated for ≥ 2 years.Methods.Patients with JIA-associated uveitis treated with IFX and ADA were managed by a standardized protocol and data were entered in the ORCHIDEA registry. At baseline, all patients were refractory to standard immunosuppressive treatment or were corticosteroid-dependent. Data recorded every 3 months were uveitis course, number/type of ocular flares and complications, drug-related adverse events (AE), and treatment switch or withdrawal. Data of patients treated for ≥ 2 years were analyzed by descriptive statistics.Results.Up to December 2014, 154 patients with ≥ 24 months followup were included in the study. Fifty-nine patients were treated with IFX and 95 with ADA. Clinical remission, defined as the absence of flares for > 6 months on treatment, was achieved in 69 patients (44.8%), with a better remission rate for ADA (60.0%) as compared to IFX (20.3%; p < 0.001). A significant reduction of flares was observed in all patients without difference between the 2 treatment modalities. The number of new ocular complications decreased in both groups but was lower for ADA (p = 0.015). No serious AE were recorded; 16.4% of patients experienced 35 minor AE and the incidence rate was lower with ADA than with IFX.Conclusion.At the 2-year followup, ADA showed a better efficacy and safety profile than IFX for the treatment of refractory JIA-associated uveitis.
The Natural Course of Diffuse Idiopathic Skeletal Hyperostosis in the Thoracic Spine of Adult Males
Authors: Kuperus Jonneke S. , Buckens Constantinus F. , Šprem Jurica , Oner F. Cumhur , de Jong Pim A. , Verlaan Jorrit-Jan 
Published: April 2018

Objective.Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by flowing bony bridges on the right side of the spine. Knowledge of the development of these spinal bridges is limited. The current longitudinal computed tomography (CT) study was designed to bridge this gap.Methods.Chest CT scans from elderly males with 2 scans (interval ≥ 2.5 yrs) were retrospectively included. Using the Resnick criteria, a pre-DISH group and a definite DISH group were identified. A scoring system based on the completeness of a bone bridge (score 0–3), extent of fluency, and location of the new bone was created to evaluate the progression of bone formation.Results.In total, 145 of 1367 subjects were allocated to the DISH groups with a mean followup period of 5 years. Overall prevalence of a complete bone bridge increased in the pre-DISH group (11.3% to 31.0%) and in the definite DISH group (45.0% to 55.8%). The mean bridge score increased significantly in both the pre-DISH and definite DISH group (p < 0.001). The new bone gradually became more flowing and expanded circumferentially.Conclusion.Over the mean course of 5 years, the new bone developed from incomplete, pointy bone bridges to more flowing complete bridges. This suggests an ongoing and measurable bone-forming process that continues to progress, also in established cases of DISH.
Dépister la dénutrition chez la personne âgée bénéficiant de soins à domicile : une évaluation de la précision diagnostique des indicateurs issus du Resident Assessment Instrument - Home Care adapté pour la Suisse
Authors: Busnel Catherine , Ludwig Catherine 
Published: April 2018

Introduction : dans la pratique des soins à domicile, l’infirmière joue un rôle fondamental dans le dépistage de personnes à risque de dénutrition. Contexte : en Suisse, l’infirmière à domicile évalue l’état nutritionnel des bénéficiaires de soins sur la base d’une évaluation gériatrique standardisée effectuée avec le RAI-HC. Objectifs : l’étude vise à estimer la précision diagnostique de l’alarme « statut nutritionnel », de l’indice de masse corporelle et de la perte de poids documentés dans RAI-HC. Méthode : un échantillon de 267 personnes âgées de 65 ans recevant des soins à domicile a été évalué au moyen du RAI-HC et du MNA-SF ® . Sensibilité, spécificité et aire sous la courbe ont été estimées pour chaque indicateur du RAI-HC en utilisant le MNA-SF ® comme étalon. Résultats : pour les indicateurs considérés, la sensibilité varie entre 16.51 % et 68.81 %, la spécificité entre 66.94 % et 99.37 %, et l’aire sous la courbe entre 0.579 et 0.708. Discussion : la précision diagnostique des indicateurs du RAI-HC n’est pas suffisante pour un dépistage optimal de la dénutrition chez les personnes âgées bénéficiant de soins à domicile. Conclusion : une évaluation complémentaire avec le MNA-SF ® est recommandée pour optimiser le dépistage précoce de personnes à risque de dénutrition.
Éclairages, dimension rhétorique et argumentation à l’épreuve des tweets de Donald Trump
Authors: Herman Thierry 
Published: April 2018

Cet article revient sur le couple « visée argumentative » et « dimension argumentative » pour les réinterroger depuis une perspective attachée à une vision classique de l’argumentation en tant que structure compositionnelle mais attentive aux intérêts de l’analyse du discours que propose Ruth Amossy. En proposant de distinguer éclairages d’une schématisation, dimension rhétorique de l’opinion énoncée sans étayages, argumentation étayée et argumentation dialectique, je crée un modèle permettant d’observer le rôle restreint (ou non) de l’argumentation dans un corpus ainsi que le poids des opinions présentées comme évidentes. Quelques tweets de Donald Trump sont passés au crible de ce modèle analytique afin de montrer le poids de la dimension rhétorique dans sa communication.
La « dimension argumentative » plurisémiotique du livre enrichi
Authors: Amadori Sara 
Published: April 2018

Le corpus de cette étude se compose de deux livres enrichis : Beauvoir, l’enquête, par Irène Frain, et Alienare, par Chloé Delaume. En puisant dans la réflexion de la rhétorique du texte numérique, j’analyse le rapport entre l’« image d’auteure » de Frain et de Delaume et l’« ethos éditorial » des deux livres, en montrant que les maisons d’édition ont essayé d’orienter la réception de ces œuvres et que leur « dimension argumentative » se manifeste d’abord à un niveau para-péritextuel. En croisant la réflexion proposée par l’analyse du discours littéraire avec l’approche développée par l’argumentation dans le discours, j’étudie les « ethè auctoriaux » projetés par les deux écrivaines dans leurs œuvres. Le niveau d’objectivité/subjectivité de leurs discours, ainsi que les stratégies rhétoriques mobilisées, ont été pris en compte pour réfléchir sur le caractère complexe et graduel de la notion de « dimension argumentative », lorsqu’elle est mise à l’épreuve des potentialités plurisémiotiques du multimédia.
Quelle dimension argumentative dans les carnets de recherche en sciences humaines ?
Authors: Mayeur Ingrid 
Published: April 2018

La présente contribution entend questionner la dimension argumentative (Amossy 2000) d’écrits scientifiques natifs du Web que sont les billets de blog. Des travaux antérieurs ont mis en évidence le rôle majeur des moyens de persuasion qui traversent le discours scientifique. Si ce type de discours est traditionnellement considéré comme un discours fermé, à l’attention des pairs, les dispositifs numériques autorisent l’élargissement potentiel du lectorat de la recherche. L’auditoire hétérogène que présuppose le contexte de l’Open Science amène dès lors à s’interroger sur les stratégies rhétoriques d’adaptation au public mises en œuvre par les carnetiers pour favoriser l’appropriation des savoirs diffusés. L’étude de la dimension argumentative des écrits de blogs, qui intègre dans l’analyse du discours scientifique la préoccupation d’une action sur l’auditoire, fournit des outils pour expliquer le recours aux moyens de preuves rhétoriques au sein de textes qui ne possèdent pas une visée argumentative explicite. Nous en testerons ici l’opérativité, en étudiant plus précisément deux carnets de recherche : l’un donnant la parole à des chercheurs dans le contexte de la société française post-attentats, l’autre se rattachant à l’actualité de la recherche – en l’occurrence, celle d’une thèse en cours, relatée par deux historiens.
Questionner un écrit professionnel au prisme de sa dimension argumentative : le cas du dossier d’usager en CSAPA
Authors: Equoy-Hutin Séverine , Lethier Virginie 
Published: April 2018

Cet article se propose d’interroger les contours définitionnels et les enjeux de la notion de « dimension argumentative » au prisme d’un écrit professionnel : le dossier d’usager produit dans une structure de travail social en addictologie (CSAPA). Il s’agit d’une part d’examiner comment la dimension argumentative peut participer à révéler les enjeux de cette pratique d’écriture dans le champ de la communication au travail. D’autre part, il s’agit de faire émerger quelques questionnements sur le cadre théorique et méthodologique de l’argumentation dans le discours, afin de le mettre à l’épreuve des spécificités des genres professionnels et plus particulièrement du dossier d’usager. Ces genres qui ne se présentent pas comme relevant d’une entreprise argumentative, se caractérisent par une forte indexation au contexte et à une finalité d’action. Face à un tel objet d’étude, dans quelle mesure et sous quelle condition observer l’argumentativité et en reconstruire les lieux discursifs ?
The experiences of employees participating in organisational corporate social responsibility initiatives
Authors: Cook Gretha , Geldenhuys Dirk J. 
Published: April 2018

Orientation: This article is about the experiences of employees who actively participate in organisational corporate social responsibility (CSR) initiatives. Research purpose: The general aim of this study was to explore the experiences of employees who participate in CSR initiatives within an organisation where a well-developed framework exists. Motivation for the study: Whilst an emergent number of studies have considered the various dimensions of CSR initiatives, the focus appears to be on stakeholders such as the recipients of CSR, organisations, consumers and shareholders but not the perspective of the employees who actively participate in CSR initiatives. Research design, approach and method: A qualitative research approach was employed with the intent of exploring the experiences of employees participating in organisational CSR initiatives. Data were collected and analysed from a purposive sample of 12 employees, by means of interactive qualitative analysis. Main findings: The study revealed that the primary driver that motivates employees to participate in CSR is love. Love sparks a sense of compassion. Compassion, coupled with an enabling environment, stimulates generosity. By being generous, a feeling of hope and inspiration is induced in both the givers and receivers of generosity. A secondary outcome of generosity and hope and inspiration is bringing about change to others, and whilst going through this journey and making a difference in the lives of others, participants experience a progressive change within themselves. This change evokes a feeling of fulfilment, and ultimately a feeling of complete joy. Contributions or value-add: This research complements existing CSR literature by focussing and reporting on the experiences of the employee as an important stakeholder.
Projecting Gender Identity in Argumentative Written Discourse
Authors: Nasri Mehdi , Biria Reza , Karimi Mahzad 
Published: April 2018

Generally speaking, writers use various resources for introducing themselves to their readers. Among these, stance and engagement discourse markers are fundamental properties which manifest the underlying interaction process between writers and readers. The present paper sought to investigate whether male and female Iranian EFL learners performed differently in terms of using stance and engagement features in their writing assignments. To this end, a corpus comprising 80 argumentative essays written by advanced learners (40 males and 40 females) were collected and analyzed respectively. Hyland’s (2008) framework of stance and engagement features including hedges, boosters, attitude markers and self-mention as well as readers’ use of engagement markers such as pronouns, directives, questions, and shared knowledge served as a tertium comprationis for comparing and contrasting the written corpora created by male and female students. For analyzing the data, a software named Hermetic Word Counter was utilized to determine the frequency of the targeted tokens. The findings revealed that male and female writers made a differential use of stance and engagement features in writing argumentative essays. The significance of the differences was further attested by the application of a chi-square statistical technique. Regarding stance-taking, it was found out that both groups followed the same patterns of stance-taking except for the use of hedges and boosters. Moreover, compared to male students, the female writers tried to create reader engagement by asking questions.
Discourse Functions of Kama in Arabic Journalistic Discourse from the Perspective of Rhetorical Structure Theory
Authors: Ayed Al-Khawaldeh Asem 
Published: April 2018

The study aims at examining the functions of the discourse marker Kama in the Arabic journalistic discourse in the light of Rhetorical Structure Theory (RST) proposed by Mann and Thompson (1987). To this end, the study compiled a small-scale corpus of journalistic discourse taken from two prominent Arabic news websites: Aljazeera.net and Alarabia.net. The corpus covers three distinct sub-genres of journalistic discourse: opinion articles, news reports, and sport reports. The journalistic discourse is chosen on the basis that it is considered as the best representative of the contemporary written Arabic and it receives a wide readership in the Arabic-speaking countries. The motivation for the study is that although it is frequently used in the written form of Arabic (particularly in the language of Arabic media), the discourse marker kama is largely neglected and very few has been said about it in the present literature on Arabic discourse markers. The current findings show that kama is found to achieve 290 occurrences in the corpus under investigation. This obviously indicates that kama is commonly used in the language of Arabic journalistic discourse, which calls for paying attention to its usage in such a type of discourse. In the light of Rhetorical Structure Theory (RST) proposed by Mann and Thompson (1987), kama was found to serve four common functions: elaboration (around 50 %), similarity (around 19 %), evidence (16 %), and exemplification (13 %). Two functions of kama (similarity and exemplification) are listed in RST while the other two are incorporated.
Translation of Taboos: The Absolutely True Diary of a Part-time Indian
Authors: Nazari Robati Fatemeh Zahra , Zand Fatemeh 
Published: April 2018

Taboo terms are intensifiers which flavor our speech. The different outlooks of each society towards these expressions due to religious, political and social attitudes makes translating them difficult. Knowing the frequency of application of translation strategies for translating these terms can be of help to other translators. This study investigated the types of taboo terms and strategies applied in their translation in the novel The Absolutely True Diary of a Part-Time Indian by Sherman Alexie. This book has been banned in the home for its taboo terms. For the purpose of this study Cabrera's (2014) categorization of taboo terms and Davoodi's (2007) strategies for translating them were applied. Concerning the 150 found taboos in the novel the types of taboo terms in order of appearance were sexual reference/body part (55.92%), psychological/physical condition (11.84%), violence (9.21), animal name (6.57%), drugs/excessive alcohol consumption (6.57%), urination/scatology (3.94%), filth (1.97%), profane/blasphemous (1.31%) and death/killing (0%). The applied strategies in order of appearance were substitution (35.33%), taboo for taboo (26%), censorship (23.33%) and euphemism (15.33%). The 61% application of substitution and taboo for taboo strategies shows the tendency of the translator to maintain the force of effect of taboo terms than eliminating their force through censorship and euphemism by 38.66% application.
Social Alienation and Displacement in Faulkner’s “Barn Burning”, Henry’s “The Social Triangle” and Mansfield’s “The Doll’s House”
Authors: Zeidanin Hussein H. , Matarneh Mohammed 
Published: April 2018

The present study questions the role of the state in reproducing class relations and interpellating lower class people. The state employs repressive and ideological apparatuses to maintain the ruling class hegemony. The apparatuses the study examines in the context of the selected stories include school, family, court and materiality. Teachers and parents in Mansfield's "The Doll's House", justices in Faulkner's "Barn Burning" and materiality in Henry's "The Social Triangle" are the state agents of repression which lower class characters in the stories could not protest or rebel against. Their assimilation of the upper class culture, the narrators assert, gets them nowhere but to eventually become alienated. This accounts for their failure to attain social mobility.