bluuebunny/crossref_metadata_2025_split huggingface dataset:
The level of interleukin-6 in acute ischemic stroke: effect on the rate of recovery in patients and on the severity of neurological defect
Authors: Sergeeva S. P. , Savin А. А. , Breslavich I. D. , Litvitsky P. F. , Arkhipov V. V. 
Published: November 2018

Interleukin 6 (IL-6) plays an important role in the pathogenesis of ischemic stroke (IS), exerting a modulating effect on a number of processes that determine the outcome of this disease. Objective: to investigate the peripheral blood levels of IL-6 in patients in the acute period of different IS pathogenetic subtypes and its effect on recovery rates. Patients and methods. The study enrolled 155 patients (74 men and 81 women; mean age, 63.8 years). A control group consisted of 28 people without IS. Pathogenetic subtype II was established in accordance with the TOAST (Trial of Org 10172 in Acute Stroke Treatment) criteria on the basis of their clinical picture and the data of computed tomography or magnetic resonance imaging and ultrasonography of the main arteries of the head. The severity of a patient's condition and a focal neurological defect and the time course of clinical changes after stroke were determined using the National Institutes of Health Stroke Scale (NIHSS). An enzyme immunoassay (EIA) was used to measure IL-6 levels on days 1, 7, and 21 after onset of IS. An enzyme immunoassay (EIA) was used to measure IL-6 levels on days 1, 7, and 21 after onset of IS. Results. In the acute period of IS, there were significantly elevated levels of IL-6. The latter reached its highest values on day 7 in patients with the atherothrombotic pathogenetic subtype of IS. On day 7 of the study, the peak concentration of IL6 was typical for patients with all subtypes of IS, except for lacunar stroke. After its increase on day 1 of the study, the IL6 level in patients with lacunar stroke did not change significantly in all other periods. In acute IS, the concentration of IL-6 was significantly influenced by the following cardiovascular risk factors: hypercholesterolemia of days 1, 7 (p<0.01) and 21 (p<0.05), hypertension in day 1 (p<0.05), diabetes mellitus on days 1 and 7 (p<0.05), and coronary heart disease in all the study periods (p<0.01). The IL-6 concentration significantly correlated with the severity of neurological defect, but did not significantly affect the rate of recovery in the patient with acute IS. Conclusion. IL-6 was established to be of prognostic value for the outcome of acute IS on day 7. The rate of recovery can be used to identify targets for therapeutic intervention.
TUFT1 promotes osteosarcoma cell proliferation and predicts poor prognosis in osteosarcoma patients
Authors: Yu Yao-Ping , He Jian-Guo , Li Ping , Qiu Ning-Hui , Wang Li-Jun , Feng Hui 
Published: November 2018

AbstractObjectiveThis study is aimed at exploring the role of TUFT1 in osteosarcomas.MethodsWe investigated the expression of TUFT1 in osteosarcoma cell lines and explored the correlation between TUFT1 expression and prognosis in osteosarcoma patients based on the expression data downloaded from Gene Expression Omnibus (GEO) website. The effects of TUFT1 on osteosarcoma cell proliferation, migration and invasion were investigated by silencing TUFT1 in osteosarcoma MG63 cell line. Finally, western blot was performed to determine the expression changes of MAPK signaling pathway related proteins after silencing TUFT1.ResultsWe found that the expression of TUFT1 was significantly up-regulated in osteosarcoma cell lines compared with the normal control. Using Kaplan-Meier analysis, we identified that high TUFT1 expression was positively correlated with poor prognosis in osteosarcoma patients. Furthermore, knockdown of TUFT1 remarkably inhibited MG63 cell proliferation, migration and invasion. Using western blot analysis, we found that the phosphorylation levels of MEK and ERK were reduced obviously in MG63 cells after silencing TUFT1 (p<0.01).ConclusionsOur results demonstrated that TUFT1 plays a promoting role in MG63 cell proliferation and metastasis and has the potential to be a predictor as well as a therapeutic target for osteosarcoma patients.
The prediction of cardiac events in patients with acute ST segment elevation myocardial infarction: A meta–analysis of serum uric acid
Authors: Wang Hailong , Yang Jianjun , Sao Jiang , Zhang Jianming , Pang Xiaohua 
Published: November 2018

AbstractObjectiveThe current study aimed to explore the predictive ability of serum uric acid (SUA) in patients suffering from acute ST segment elevation myocardial infarction (STEMI).MethodPubMed, EMBASE, Cochrane Library, and Medline databases were systematically searched from their respective inceptions to February 2018. Systematic analysis and random-effects meta–analysis of prognostic effects were performed to evaluate STEMI outcomes [i.e., in-hospital mortality, one-year mortality, in-hospital Major Adverse Cardiovascular Events (MACE)] in relation to SUA.ResultsA total of 12 studies (containing 7,735 patients with acute STEMI) were identified (5,562 low SUA patients and 3,173 high SUA patients). Systematic analysis of these studies showed that high SUA patients exhibited a higher incidence of in-hospital MACE (OR, 2.30; P < 0.00001), in-hospital mortality (OR, 3.03; P < 0.0001), and one-year mortality (OR, 2.58; P < 0.00001), compared with low SUA patients.ConclusionsAcute STEMI patients with high SUA exhibited an elevated incidence rate of in-hospital MACE, in-hospital mortality, and one-year mortality. Further randomized controlled trials will be needed to verify these results.
Risk expansion of Cr through amphibious clonal plant from polluted aquatic to terrestrial habitats
Authors: Xu Liang , Wu Xiao , Xiang Dan 
Published: November 2018

AbstractResource sharing between the connected ramets of clonal plants through physiological integration can increase the tolerance of plants to environmental stress. However, the role of physiological integration in the translocation of heavy-metal pollutants between different habitats receives little attention, especially in the aquatic-terrestrial ecotones. An amphibious clonal plant Alternanthera philoxeroides was used to simulate plant expansion from unpolluted soil to a chromium (Cr)-polluted water environment. Basal older ramets growing in unpolluted soil were connected or disconnected with apical younger ramets of the same fragments in polluted environments at different Cr concentrations. Harvested basal ramets were also used for decomposition tests for the loss of residual mass and release of Cr to soil. With increasing Cr concentration there was reduction in biomass of the apical ramets, especially those separated from the basal parts. Cr was detected in the basal ramets with connection to apical parts. The decomposition of plant litter from the basal ramets connected with polluted apical parts might release retained Cr to unpolluted soil. The amount and chemical forms of Cr in the plant litter changed over time. It is concluded that Cr could be transferred from polluted aquatic to unpolluted terrestrial habitats through amphibious clonal plants.
Overexpression of Zinc Finger Transcription Factor ZAT6 Enhances Salt Tolerance
Authors: Tang Wei , Luo Caroline 
Published: November 2018

AbstractThe purpose of the present investigation is to examine the function of the C2H2-type zinc finger transcription factor of Arabidopsis thaliana 6 (ZAT6) in salt stress tolerance in cells of rice (Oryza sativa L.), cotton (Gossypium hirsutum L.) and slash pine (Pinus elliottii Engelm.). Cells of O. sativa, G. hirsutum, and P. elliottii overexpressing ZAT6 were generated using Agrobacterium-mediated genetic transformation. Molecular and functional analysis of transgenic cell lines demonstrate that overexpression of ZAT6 increased tolerance to salt stress by decreasing lipid peroxidation and increasing the content of abscisic acid (ABA) and GA8, as well as enhancing the activities of antioxidant enzymes such as ascorbate peroxidise (APOX), catalase (CAT), glutathione reductase (GR), and superoxide dismutase (SOD). In rice cells, ZAT6 also increased expression of Ca2+-dependent protein kinase genes OsCPK9 and OsCPK25 by 5–7 fold under NaCl stress. Altogether, our results suggest that overexpression of ZAT6 enhanced salt stress tolerance by increasing antioxidant enzyme activity, hormone content and expression of Ca2+-dependent protein kinase in transgenic cell lines of different plant species.
Sini decoction intervention on atherosclerosis via PPARγ-LXRα-ABCA1 pathway in rabbits
Authors: Ju Shicong , Chang Xiaorong , Wang Jun , Zou Xufeng , Zhao Zhao , Huang Zhen , Wang Yuanhong , Yu Baosheng 
Published: November 2018

AbstractAimSini decoction (SND) is a commonly used herbal formula showing lipid-lowering effects and is applied in traditional Chinese medicine (TCM) for the treatment of cardiovascular disease (CVD) and atherosclerosis (AS). However, the mechanisms behind its anti-atherosclerotic effects are still unknown, and will be investigated in this study.MethodsAS was induced in rabbits by high fat diet (HFD) and treated with solvent (HFD group), atorvastatin (Ator group), or SND (SND group) for 12 weeks. Healthy rabbits (Chow group) were used as control. Serum and liver homogenates were collected, and lipid profiles as well as serum ApoA-I and ApoB were examined. Histopathological changes and lipid deposition in the proximal aorta and liver were detected by Oil red O staining. Western blot was used to detect the expression of ABCA1, ApoA-I, ApoB, PPARγ, and LXRα in liver, peritoneal macrophages, peripheral mononuclear cells (PMC), and adipose tissues.ResultsSND significantly attenuated the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol(LDL-C) in serum and liver. However, high density lipoprotein cholesterol (HDL-C) dramatically increased. SND treatment also decreased lipid deposition and improved the structure of the liver and aorta. Furthermore, SND enhanced the expression levels of ABCA1, PPARγ, and LXRα in liver, adipose tissues, PMC, and peritoneal macrophages. It also upregulated hepatic and serum ApoA-I expression and serum ApoA-I/ApoB ratio. CONCLUSIONS:SND treatment relieved AS, improved lipid profiles, and increased serum HDL-C level. The potential mechanism behind this might be the improvement of reverse cholesterol transport (RCT) involved with enhanced expression of ABCA1, ApoA-I, PPARγ, and LXRα.
Structural phenomenology: A reading of the early Husserl
Authors: Aurora Simone 
Published: November 2018

AbstractThe aim of this paper is to show that Edmund Husserl’sLogical Investigationsshould be regarded as one of the fundamental sources of structuralism. Husserl’s version of structuralism is, however, quite original in many respects. Indeed, what Husserl advocates in his works can be defined, following and expanding a line of research inaugurated by scholars like Elmar Holenstein and Giovanni Piana (see Holenstein, E. 1975.Roman Jakobsons phänomenologischer Strukturalismus. Frankfurt: Suhrkamp, Holenstein, E. 1976.Linguistik, Semiotik, Hermeneutik: Plädoyers für eine strukturale Phänomenologie. Frankfurt: Suhrkamp, Holenstein, E. In publication.Phenomenological Phenomenology of Language: Scattered Papers. Geneva: sdvig, Piana, G. 2013a. L'idea di uno strutturalismo fenomenologico. In G. Piana (ed.),Strutturalismo fenomenologico e psicologia della forma, 5–17.http://www.lulu.com/shop/giovanni-piana/strutturalismo-fenomenologico-e-psicologia-della-forma/paperback/product-21332317.html(accessed 20 February 2018), Piana, G. 2013b. Momento figurale e qualità ghestaltica. In G. Piana (ed.),Strutturalismo fenomenologico e psicologia della forma, 101–119.http://www.lulu.com/shop/giovanni-piana/strutturalismo-fenomenologico-e-psicologia-della-forma/paperback/product-21332317.htmlaccessed 20 February 2018), in terms ofphenomenological structuralismor ofstructural phenomenology.
A Semiotic Interpretation of Online Selfie Culture
Authors: Liu Yin 
Published: November 2018

Abstract
The awakening or crisis of individual self-consciousness has been frequently included in the study of online selfie culture, while the reinforcement of public self-consciousness, the strengthening of civil confidence, and even the resurgence of national confidence can be detected from its popularity when studied with the application of Lotman’s cultural semiotics, especially the unique dialogic mechanism as well as Lotman’s viewpoint on the space–time structure of the semiosphere. With dialogue situation created and meaning generated, textual dialogues help the construction of self-consciousness through the “I–I” and “I–s/he” system; cultural dialogues make it ultimately welcomed by mainstream culture, which embodies the enhancement of mass self-consciousness. In the semiosphere, selfies reconstruct our self-consciousness in the time–space structure of cultures. The shift of self-consciousness from low-profile to high-profile represents the booming confidence of the Chinese. As a work of art is a finite model of an infinite universe, a “picture of the world,” selfies are also the pictures of growing national confidence.
Japanese Semiotic Studies in China
Authors: Li Guangzhen , Jia Lei 
Published: November 2018

Abstract
The attention to semiotic research in Japan and exchanges concerning this within China's academic circles have demonstrated different characteristics at different stages of the development of this field. In the 1980s and 1990s, academic articles relevant to this research mainly focused on the review of Japanese semiotic studies, with frequent exchanges in the academic circles of both countries. However, since the beginning of the new millennium, Chinese scholars of semiotics have begun to apply semiotic theories to Japanese Studies and have obtained a series of concrete and solid academic achievements, shedding new light on Japanese Studies in China.
Creating Society in Orwell’s1984
Authors: Kalelioğlu Murat 
Published: November 2018

AbstractIn this paper, the idea of constructing a new society in George Orwell’s1984is analyzed in the context of the Paris School’s semiotics trajectory. Saussurean legacy, which heavily sheds light on the semiotic conception of the school proposed by Greimas, asserts the significance of dichotomies for signs to gain their meaning. Accordingly, the study is grounded on thedesiredandnon-desiredcontrariety to make the analysis with the semiotic square meaningful. It is possible to encounter the traces of the proposed idea pertaining to the struggle of forming an ideal society at all levels of meaning, predominantly at the deep level as the proposed idea represents the elementary meaning of the narrative, throughout the text. Considering the approach,desiredsociety gains its meaning in the face of thenon-desiredone relativistically. Regarding the opposition theory of Saussure, what is good for the Party is not supposed to be good for the Opponents. For this reason, the idea of creating society is on the battleground, as there is an uphill fight between the ruling Party and the Opponents. The formation ofdesired societyis revealed thanks to the semiotic square by focusing on both positive and negative transition processes. The really interesting aspect that we encountered is the vicious unended cycle and the war that will never end between the stated groups within the framework of the ideology/axiology perspective.
Analysis of the Buddhist Conversion of Great Sage
Authors: Wang Feng (Robin) , Humblé Philippe 
Published: November 2018

AbstractAs one of the four great classical novels of Chinese literature,The Journey to the Westnarrates a legendary Buddhist pilgrimage. Until now, the religious conversion in the novel remains much less explored by academia. We propose an innovative approach to addressing this shortfall by conducting a corpus-based investigation into the characterization of the protagonist “Great Sage.” We use the corpus tools BFSU PowerConc 1.0 and LancsBox v.2.0.1 to calculate and visualize the collocation networks of Great Sage: for one thing, to contextualize the complex interactions between him and the external environment; for another, to define and compare different phases of the character’s evolution. The collocational networks are derived by means of a quantitative approach, i.e. a mutual information (MI) score with collocation cutoff values. This lays an objective foundation for a subsequent qualitative interpretation of how the protagonist’s identity is forged in his conversion. Further, some associated literary and theological scholarships are woven into our text-based analysis.
The Rise of Semio-Narratology
Authors: Zhao Henry Yiheng , Fang Xiaoli 
Published: November 2018

Abstract
Yiheng Zhao is an eminent scholar of narratology and semiotics and a distinguished professor at Sichuan University. In this interview, Professor Zhao describes how semio-narratology is rising in China. He talks about his lifelong studies of form, including narratology, semiotics, and the theory of meaning, which can be called his “meaning trilogy,” corresponding to his three books, A general narratology, Semiotics, and Philosophical semiotics: The coming into being of the world of meaning. Zhao especially introduces his insightful ideas on the development of narratology and social semiotics and how he applies semiotic theory to narratology to build the interdisciplinary discipline of a general narratology, aka semio-narratology. Meanwhile Professor Zhao also shares his research methods and experience. He believes that scholars have to keep making breakthroughs and innovations and each make their own way.
Occurrence and Distribution of Races 713, 733 and 734 of Sunflower Downy Mildew Pathogen in the Russian Federation
Authors: Iwebor Maria , Antonova Tatiana , Saukova Svetlana 
Published: November 2018

AbstractThe samples of Plasmopara halstedii (the causal agent of sunflower downy mildew) were collected on sunflower fields in south of the Russian Federation: in the Krasnodar, Rostov and Stavropol regions, and in the Republic of Adygea in 2016 and 2017. Virulence code of 545 isolates was identified; i. e. 280 isolates originating from 24 fields in 2016, and 265 isolates from 17 fields in 2017. Races 330, 334, 710 and 730, widespread within the region in previous years, were found in all mentioned areas. In addition, races 713, 733 and 734 have been detected in several districts of the Krasnodar region since 2016. This is the first report of these races in Russia and above that the first record throughout Europe and Asia for the races 733 and 734. The identification of new P. halstedii races was confirmed by the method of cross inoculations from individual differential lines. The phenotype corresponding to virulence code 734 was in some cases disclosed as a mixture of race 334 with 710 or 730. The presence of several P. halstedii races on an individual plant was also confirmed for the first time in the territory of the Russian Federation.
The relationship between the dominant humor style, emotional intelligence, and problem-solving skills in trainee teachers in Turkey
Authors: Karahan T. Fikret , Yalcin B. Murat , Erbas Melda M. , Ergun Seda 
Published: November 2018

AbstractWe investigated the relation between humor styles used by 1456 volunteer trainee teachers and their emotional intelligence and problem-solving skills. The participants completed the Humor Styles Questionnaire (HQS), Revised Schutte Emotional Intelligence Test (R-SSEIT) and Problem-Solving Inventory (PSI). The highest-scoring HQS subscale for each participant was taken as the index HQS subscale and the two adaptive HQS subscale (affiliative and self-enhancing) scores and two maladaptive HQS subscale (aggressive and self-defeating) scores were added together in order to calculate each participant’s preferred total adaptive and maladaptive reflective humor style scores. Based on this score, every participant was identified as a maladaptive or adaptive reflective humor user. Women had better PSI and R-SSEIT scores compared to men (p<0.001). The highest index HQS subscales were aggressive humor (234, 36.6%) for men and affiliative humor (334, 40.9%) for women participants. Five hundred fifty women (67.4%) and 264 men (32.4%) were identified as adaptive humor dominant (x2=49.757, p<0.001). Adaptive humor styles (affiliative r=0.293, and self-enhancing r=0.263) were positively correlated with EI, while there was a negative relation between maladaptive humor styles (aggressive r=−0.294, and self-defeating r=−0.273) and EI. Affiliative humor and self-enhancing humor were positively correlated with problem-solving skills whereas aggressive humor and self-defeating humor were negatively correlated with problem-solving skills. The adaptive humor styles (affiliative r=−0.429, and self-enhancing r=−0.365) were negatively correlated with PSI, and positively correlated with maladaptive humor styles (aggressive r=0.426, and self-defeating r=0.323). At linear regression analysis, it was confirmed that humor styles were in correlation with EI and PSI. At binary logistic regression analysis, female gender (OR=1.9), and possessing higher levels of problem-solving skills (OR=1.058) and EI (OR=1.011) were identified as independent factors for using adaptive dominant humor styles.
The fatty acid profile and stable isotope ratios of C and N of muscle from cattle that grazed grass or grass/clover pastures before slaughter and their discriminatory potential
Authors: Moloney A.P. , O’Riordan E.G. , Schmidt O. , Monahan F.J. 
Published: November 2018

Abstract
Consumption of grazed pasture compared to concentrates results in higher concentrations, in beef muscle, of fatty acids considered to be beneficial to human health. Little information is available on the influence of the type of grazed forage. Our objectives were to determine 1) the effect of inclusion of white clover in a grazing sward on the fatty acid profile of beef muscle and 2) the potential of the fatty acid profile and stable isotope ratios of C and N to discriminate between beef from cattle that grazed grass-only or grass/clover swards before slaughter. A total of 28 spring-born Charolais steers grazed from March until slaughter in October, either on a perennial ryegrass (Lolium perenne L.) sward that received approximately 220 kg N/ha or a perennial ryegrass–white clover (Trifolium repens L.) sward that received 50 kg N/ha. The longissimus muscle from cattle finished on grass/clover had a higher (P < 0.05) proportion of C18:2 and C18:3 but a lower (P < 0.05) proportion of conjugated linoleic acid and δ15N value than animals finished on the grass-only sward. Discriminant analysis using the fatty acid data showed that, after cross-validation, 80.7% of grass/clover and 86.1% of grass-only muscle samples were correctly classified. Discriminant analysis using the stable isotope data showed that, after cross-validation, 95.7% of grass/clover and 86.5% of grass-only muscle samples were correctly classified. Inclusion of white clover in pasture is likely to have little effect on healthiness of meat for consumers. However, changes in fatty acids and stable isotopes can be used to distinguish between grass/clover-fed and grass-only-fed beef.