bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo Assessment of an Endolymphatic Hydrops Gradient Along the Cochlea in Patients With Menière's Disease by Magnetic Resonance Imaging—A Pilot Study
Authors: Bier Georg , Bongers Malte Niklas , Schabel Christoph , Heindel Walter , Ernemann Ulrike , Hempel Johann-Martin 
Published: October 2018

Objective:
To assess three strategies for evaluation and description of potential endolymphatic hydrops (EH) gradients along the cochlea in patients with Menière's disease.

Study Design:
Prospective observational study.

Methods:
Ten patients with definite Menière's disease revealed by magnetic resonance imaging were included in this prospectively conducted pilot study. The presence of cochlear endolymphatic hydrops as well as a potential hydrops gradient along the cochlea were subjectively evaluated by two readers. Furthermore, both readers performed planimetric measurements of the relative extent of endolymphatic hydrops in the cochlear turns for calculation of an apico-basal-index (ABI) and an average gradient slope of the endolymphatic hydrops. These models were correlated with the available pure tone audiometry (PTA).

Results:
Qualitatively, 13 of 16 inner ears presented an apical EH distribution. The median ABI was 1.69 for patients with low-tone hearing loss and 1.17 for patients with a flat PTA curve (p = 0.03). The median EH slope was 7.44 and correlated with the steepness of the PTA (ρ = 0.583; p = 0.018). The subjective analysis and the slope model were best fit for prediction of a low-tone hearing loss type with sensitivities of 100% (specificity, 42.86%) and 88.9% (specificity, 71.4%), respectively. The inter-reader agreement in all three approaches was considered substantial to perfect.

Conclusion:
The presented qualitative approach and the slope model represent reliable methods for the description of a potential EH gradient along the cochlea. Furthermore, the average EH steepness along the cochlea correlates with the type of hearing loss.
Understanding Pancreatic Diseases Using Animated Pancreas Patient
Authors: Munigala Satish , Gardner Timothy B. , O'Reilly Eileen M. , Castillo Carlos Fernández-del , Ko Andrew H. , Pleskow Douglas , Mills Jeannine B. , Vollmer Charles M. , Searle Nicholas A. , Alsante Matthew , Holt Jane M. , Gelrud Andres 
Published: October 2018

Objectives
The aim of this study was to evaluate the impact of Animated Pancreas Patient (APP) educational modules (APP website and YouTube) on pancreas education, awareness, and health outcomes.

Methods
This was a retrospective study of APP metrics data from September 2013 to October 2017. We evaluated audience reach (number of visit sessions, unique visitors, page views) and calculated top views by media type (animation, expert video, patient video, and slide show) and top retention videos from the modules. We also assessed the educational impact through learner feedback survey.

Results
The APP had 1,475,252 views (547,693 unique visitors, 63.1% in United States) during the study period. Most popular topic viewed among the animations was “Role and Anatomy of the Pancreas” (n = 361,116), and most common expert video viewed was “Chronic Pancreatitis: What Foods and Beverages Should I Avoid?” (n = 31,667). Participants who completed the online feedback survey reported knowledge gains and commitments to change.

Conclusions
Pancreas education in visual formats of learning provided by APP demonstrated wide reach and has substantial potential to inform and impact behaviors of patients and caregivers. Continued efforts should be made to provide patient resources that address health literacy and patient education and respond to patient needs for better quality of life and improved health outcomes in pancreatic diseases.
Improving Functional Assessment in Older Adults Transitioning From Hospital to Home
Authors: Liebzeit Daniel , King Barbara , Bratzke Lisa , Boltz Marie 
Published: October 2018

Purpose/Objectives:The purpose of this article is to highlight how scientists have assessed all components of functional status in older adults transitioning from hospital to home to date, discuss ways of improving assessment of functional status, and discuss implications for case management research and practice.Primary Practice Setting(s):This article focuses on case management of older adults transitioning from hospital to home.Findings/Conclusions:There any many ways to assess functional status, including basic activities of daily living (BADL), instrumental activities of daily living (IADL), and other nonphysical domains of function such as leisure, social, and productive activities. However, assessment of function in older adults transitioning from hospital to home is primarily limited to BADL. Nonphysical domains of functional status have been linked to important outcomes in community-dwelling older adults and could give clinicians and researchers a better understanding of how older adults are functioning, as well as allow for earlier recognition of those who are beginning to experience functional decline.Implications for Case Management Practice:In case management, it is important to ask older adults about goals regarding their functional status and how they think about their functioning in the hospital and at home. Early identification of older adults' functional goals while in the hospital is the first step toward regaining their ideal or premorbid function after discharge to home. To best determine baseline functional status, we may need to consider assessments that can measure multiple domains of functioning in older adults, such as the Sickness Impact Profile. Gaining a more comprehensive understanding and assessment of functional status for hospitalized older adults would help inform discharge destinations and improve transitions in care.
Clinical Nurse Specialists’ Perceptions of a Mental Health Patient Portal
Authors: Mayhew Cari , Strudwick Gillian , Waddell Janice 
Published: October 2018

Purpose:
The purposes of this study were to explore clinical nurse specialists’ views of the potential influence of a mental health portal on nursing practice and to identify portal implementation strategies.

Methods:
A qualitative descriptive approach was used. Semistructured interviews were conducted with 5 clinical nurse specialists. Two independent coders conducted an inductive content analysis of the transcribed interviews to generate codes describing patterns in the data to identify originating themes.

Results:
The content analysis uncovered the following 4 themes: (1) implementation strategies, (2) nurse likelihood to recommend, (3) impact on nursing practice, and (4) perceived influence on patients.

Conclusion:
Direct care nurses may benefit from education and coaching on how to document in the record using patient-centered language that is understandable to patients who may be reading it. In addition, the use of patient portals should be designed to fit into nurses’ existing clinical workflows. Finally, more research is needed to identify the benefits and unintended consequences of patient portals within a mental health context.
A Best Practice Initiative to Optimize Transfer of Young Adults With Osteogenesis Imperfecta From Child to Adult Healthcare Services
Authors: Isabel Carrier Jaimie , Siedlikowski Maia , Chougui Khadidja , Plourde Sylvie-Anne , Mercier Corinne , Thevasagayam Gloria , Lafrance Marie-Élaine , Wong Trudy , Bilodeau Claudette , Michalovic Alisha , Thorstad Kelly , Rauch Frank , Tsimicalis Argerie 
Published: October 2018

Purpose
The aims of this study were (1) to review the current body of knowledge on the transition experiences of adolescents with osteogenesis imperfecta (OI) and appraise the evidence available on transfer summary tools, (2) to develop guidelines for the successful transition of adolescents with OI from child to adult healthcare services, and (3) to create a transfer tool tailored to adolescents with OI.

Design and Methods
This knowledge synthesis study was overseen by an interprofessional expert task force at Shriners Hospitals for Children–Canada and entailed (1) review of the literature, (2) development of guidelines, and (3) creation of a tool.

Results
The tool was created from evidence compiled from case reports, clinical examples, and nonexperimental studies.

Conclusion
The transfer tool proposes guidelines designed to facilitate a smooth transition from child to adult healthcare services. It also offers creation of a clinically meaningful, person-focused, OI transfer tool that may in turn help improve the transition experience for adolescents. This study significantly contributes to the dearth of literature on transition experiences in OI and on transfer tools in general. Future research is needed to evaluate the implementation and evaluation of the OI transfer tool in practice.
Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected With Continuous Long-Term Neonatal Electroencephalography Monitoring
Authors: Sharpe Cynthia , Davis Suzanne L , Reiner Gail E. , Lee Lilly I , Gold Jeff J , Nespeca Mark , Wang Sonya G , Joe Priscilla , Kuperman Rachel , Gardner Marissa , Honold Jose , Lane Brian , Knodel Ellen , Rowe Deborah , Battin Malcolm R. , Bridge Renee , Goodmar Jim , Castro Ben , Rasmussen Maynard , Arnell Kathy , Harbert MaryJane , Haas Richard 
Published: October 2018

Purpose:
Continuous video electroencephalography (cEEG) monitoring is the recommended gold standard of care for at-risk neonates but is not available in many Neonatal Intensive Care Units (NICUs). To conduct a randomized treatment trial of levetiracetam for the first-line treatment of neonatal seizures (the NEOLEV2 trial), we developed a monitoring infrastructure at five NICUs, implementing recent technological advancements to provide continuous video EEG monitoring and real-time response to seizure detection. Here, we report on the feasibility of providing this level of care.

Methods:
Twenty-five key informant interviews were conducted with study neurologists, neonatologists, coordinators, and EEG technicians from the commercial EEG monitoring company Corticare. A general inductive approach was used to analyze these qualitative data.

Results:
A robust infrastructure for continuous video EEG monitoring, remote review, and real-time seizure detection was established at all sites. At the time of this survey, 260 babies had been recruited and monitored for 2 to 6 days. The EEG technician review by the commercial EEG monitoring company was reassuring to families and neonatologists and led to earlier detection of seizures but did not reduce work load for neurologists. Neurologists found the automated neonatal seizure detector algorithm provided by the EEG software company Persyst useful, but the accuracy of the algorithm was not such that it could be used without review by human expert. Placement of EEG electrodes to initiate monitoring, especially after hours, remains problematic.

Conclusions:
Technological advancements have made it possible to provide at-risk neonates with continuous video EEG monitoring, real-time detection of and response to seizures. However, this standard of care remains unfeasible in usual clinical practice. Chief obstacles remain starting a recording and resourcing the real-time specialist review of suspect seizures.
Homologous expression and characterization of gassericin T and gassericin S, a novel class IIb bacteriocin produced byLactobacillus gasseriLA327
Authors: Kasuga Genki , Tanaka Masaru , Harada Yuki , Nagashima Hiroshi , Yamato Taisei , Wakimoto Ayaka , Ito Yoshiyuki , Kawai Yasushi , Kok Jan , Masuda Testuya 
Published: October 2018

AbstractLactobacillus gasseriLA327 isolated from the large intestine tissue in humans is a bacteriocinogenic strain and is predicted to produce two kinds of class IIb bacteriocins, i.e. gassericin T (GT) and acidocin LF221A (Acd LF221A). In this study, DNA sequencing of the genes for GT and Acd LF221A onLb. gasseriLA327 revealed that the amino acid sequences for GT completely corresponded with those ofgatexcept for GatK (histidine kinase). However, those for the Acd LF221A had analogues which differed in at least one amino acid residue to be a putative class IIb bacteriocin designated as gassericin S (GS). By deletion test of GT structural genes (gatAX), the LA327 strain retained the bacteriocin activity, and the LA327 mutant strain lacking the ABC-type transporter gene (gatT) completely lost the bacteriocin activity. This indicates that LA327 strain is a GS producer, and GS production is performed viagatwith the inclusion ofgatT. Homologous expression using deletion mutants for GS and GT containing each single peptide elucidated that GS (GasAX) and GT (GatAX) showed synergistic activity as class IIb bacteriocins, respectively, and no synergistic activity was observed between each peptide of GS and GT. The molecular mass of GS was estimated to be theoretical ca. 5,400 Da byin situactivity assay after SDS-PAGE, clarifying that GS was actually expressed as an active class IIb bacteriocin. Furthermore, stability of GS expressed against pH, heat and protease was determined.ImportanceWe determined the complete DNA sequence for GS, a novel class IIb bacteriocin ofLb. gasseri, and succeeded to express GS as active bacteriocins. Our results clarified the interaction of each class IIb component peptide for GT in addition to GS via construction of homologous mutants which were not dependent on the purification. These data may demonstrate the characteristics of class IIb bacteriocins forLb. gasseri.
Ligand Geometry Controls Adhesion formation via Integrin Clustering
Authors: Changede Rishita , Cai Haogang , Wind Shalom , Sheetz Michael P. 
Published: October 2018

AbstractIntegrin-mediated cell matrix adhesions are key to sensing the geometry and rigidity of the extracellular environment to regulate vital cellular processes.In vivo, the extracellular matrix (ECM) is composed of a fibrous mesh. To understand the geometry that supports adhesion formation on fibrous substrates, we patterned 10 nm gold-palladium single lines or pairs of lines (total width within 100 nm), mimicking thin single ECM fibers or a minimal mesh geometry, respectively and functionalized it with integrin binding ligand Arg-Gly-Asp (RGD). Single lines showed reduced focal adhesion kinase (FAK) recruitment and did not support cell spreading or formation of focal adhesions, despite the presence of a high density of integrin-binding ligands. Using super resolution microscopy, we observed transient integrin clusters on single lines, whereas stable 110 nm integrin clusters formed on pairs of lines similar to those on continuous substrates. This indicated that two-dimensional ligand geometry is required for adhesion formation on rigid substrates. A mechanism to form modular 100nm integrin clusters bridging the minimal fiber mesh would require unliganded integrins. We observed that integrin mutants unable to bind ligand co-clustered with ligand-bound integrins when present in an active extended conformation. Thus, these results indicate that functional integrin clusters are required to form focal adhesions and unliganded integrins can co-cluster to bridge between thin matrix fibers and can form stable integrin adhesions on dense fibrous networks.
An assembly sequence optimization oriented small world networks genetic algorithm and case study
Authors: Zhao Liping , Li Bohao , Chen Hongren , Yao Yiyong 
Published: October 2018

Purpose
The assembly sequence in the product assembly process has effect on the final product quality. To solve the assembly sequence optimization problem, such as rotor blade assembly sequence optimization, this paper proposes a small world networks-based genetic algorithm (SWN_GA) to solve the assembly sequence optimization problem. The proposed approach SWN_GA consists of a combination between the standard Genetic Algorithm and the NW Small World Networks.

Design/methodology/approach
The selection operation and the crossover operation are improved in this paper. The selection operation remains the elite individuals that have greater fitness than average fitness and reselects the individuals that have smaller fitness than average fitness. The crossover operation combines the NW Small World Networks to select the crossover individuals and calculate the crossover probability.

Findings
In this paper, SWN_GA is used to optimize the assembly sequence of steam turbine rotor blades, and the SWN_GA was compared with standard GA and PSO algorithm in a simulation experiment. The simulation results show that SWN_GA cannot only find a better assembly sequence which have lower rotor imbalance, but also has a faster convergence rate.

Originality/value
Finally, an experiment about the assembly of a steam turbine rotor is conducted, and SWN_GA is applied to optimize the blades assembly sequence. The feasibility and effectiveness of SWN_GA are verified through the experimental result.
A new type of inner-side working head for automatic drilling and riveting system
Authors: Jiang Junxia , Bian Chen , Bi Yunbo , Ke Yinglin 
Published: October 2018

Purpose
The purpose of this paper is to design, analyze and optimize a new type of inner-side working head for automatic horizontal dual-machine cooperative drilling and riveting system. The inner-side working head is the key component of automatic drilling and riveting system, and it is a challenge to design an inner-side working head which must be stiffness and stable with a compact structure to realize its functions.

Design/methodology/approach
According to the assembly structure features of large aircraft panels and riveting process requirements, a new type of inner-side working head is designed for pressure riveting. The force condition of the inner-side working head during the riveting process is analyzed and the deformation model is established. Design optimization is performed based on genetic algorithm and finite element analysis. The optimized inner-side working head is tested with automatic horizontal dual-machine cooperative drilling and riveting system.

Findings
The deformation model provides the precision compensation basis for control system. Application test results show that the automatic drilling and riveting system can realize assembly of large aircraft panel with high efficiency and quality through the inner-side working head.

Research limitations/implications
The inner-side working head has been used in aircraft panel assembly.

Practical implications
The inner-side working head has been used in aircraft panel assembly.

Originality/value
This paper presents the design, analysis and optimization of a new type of inner-side working head which can realize automatic riveting for aircraft panel. The research will promote the automation of aircraft panel assembly.
Adaptive visual servoing control for an underwater soft robot
Authors: Xu Fan , Wang Hesheng , Chen Weidong , Wang Jingchuan 
Published: October 2018

Purpose
Soft robotics, regarded as a new research branch of robotics, has generated increasing interests in this decade and has demonstrated its outperformance in addressing safety issues when cooperating with human beings. However, there is still lack of accurate close-loop control because of the difficulty in acquiring feedback information and accurately modeling the system, especially in interactive environments. To this end, this paper aims to improve the controllability of the soft robot working in specific underwater environment. The system dynamics, which takes complicated hydrodynamics into account, is solved using Kane’s method. The dynamics-based adaptive visual servoing controller is proposed to realize accurate sensorimotor control.

Design/methodology/approach
This paper presents an image-based visual servoing control scheme for a cable-driven soft robot with a fixed camera observing the motions. The intrinsic and extrinsic parameters of the camera can be adapted online so that tedious camera calibration work can be eliminated. It is acknowledged that kinematics-based control can be only applied into tasks in the free space and has limitation in accelerating the motion speed of robot arms. That is, one must consider the unneglectable interaction effects generated from the environment and objectives when operating soft robots in such interactive control tasks. To extend the application of soft robots into underwater environment, the study models system dynamics considering complicated hydrodynamic effects. With the pre-knowledge of the external effects, the performance of the robot can be further improved by adding the compensation term into the controller.

Findings
The proposed controller has theoretically proved its convergence of image error, adaptive estimation error and the stability of the dynamical system based on Lyapunov’s analysis. The authors also validate the performance of the controller in positioning control task in an underwater environment. The controller shows its capacity of rapid convergence to and accurate tracking performance of a static image target in a physical experiment.

Originality/value
To the best of the authors’ knowledge, there is no such research before that has developed dynamics-based visual servoing controller which takes into account the environment interactions. This work can thus improve the control accuracy and enhance the applicability of soft robotics when operating in complicated environments.
The rise of mobile internet: the adoption process at the bottom of the pyramid
Authors: Rahman Muhammad Sabbir , Mannan Mahafuz , Amir Riasat 
Published: October 2018

Purpose
The purpose of this study is to provide an insight into the adoption process of mobile internet (M-internet) among bottom-of-the-pyramid (BoP) customers.

Design/methodology/approach
An empirical survey was used to test the proposed hypotheses. Data were collected from a total of 387 BoP customers from Bangladesh. PLS-SEM was applied to test the proposed model.

Findings
The findings in this study reveal that BoP customers’ life satisfaction, internet literacy, perceived usefulness and perceived ease of use significantly influence a customer’s intention to use M-internet, while these relationships are partially mediated by the attitude toward M-internet. Furthermore, price perception was found to directly influence intention to use M-internet and to have a positive moderating effect on the relationship between attitude toward M-internet and intention to use M-internet. Also, intention to use M-internet was found to have a significant influence on BoP customer’s M-internet adoption behavior.

Practical implications
The findings of this study help to understand what drives and impedes the M-Internet adoption behavior of BoP customers in a developing country like Bangladesh.

Originality/value
This is the first study that incorporated BoP customers’ life satisfaction and internet literacy to investigate the BoP customers’ adoption process of M-internet in the context of developing countries. Overall, this study contributes to the limited literature regarding the BoP customers’ M-internet adoption behavior. The results of this study will help the M-internet service providers of Bangladesh and other similar developing countries to understand the BoP customer’s adoption process regarding M-internet to create successful policies and strategies both for the service providers and policymakers.