bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrofit de Painéis Elétricos de um Hospital da Região Serrana com Adequação à NR-10.
Authors: Rodrigues Jose Henrique Moreira , Ferreira Alex Franco , De Carvalho José Thomaz , Campista Ferraz Rodrigo De Souza 
Published: February 2018

O Retrofit é o processo de modernização de algum equipamento já considerado ultrapassado ou fora de norma. O projeto tem como fundamento a adequação de um painél elétrico de força e comando de uma instalação industrial, com o intuito de normatizá-lo de acordo com a NR 10, que diz respeito a Segurança em Instalações e Serviços em Eletricidade. Para adequação proposta, realizou-se inicialmente um estudo das normas vigentes sobre o tema, elaborou-se então um check-list para levantamento das substituições de equipamentos necessárias e por fim um relatório justificando detalhadamente cada item necessário à substituição. As modificações então realizadas foram executadas visando a segurança e eficiência de energia elétrica das instalações com aplicação da NR 10 e posteriormente a proposta execução do Retrofit foi aplicada à outros painéis de mesmas características e especificações técnicas. Conclui-se que o sistema elétrico do local estudado ficará normatizado de acordo com as Leis Vigentes e conforme a NR 10, trazendo maior segurança, confiança e eficiência. O trabalho serve de referência par aplicação das adequações de forma satisfatória em outros painéis elétricos da mesma instalação.
An LC-MS/MS Method for Synchronous Determination of Paclitaxel and Curcumin: Development, Validation, and Application to a Pharmacokinetic Study
Authors: Qiu Kaifeng , Liu Chunxia , Shi Yonghui , Yu Xiaoxia , Chen Guanghui , Wu Junyan , Li Guocheng , Lv Li 
Published: February 2018

Background:
A chromatography tandem mass spectrometry method was first established and
validated for the synchronous determination of curcumin(CUR) and paclitaxel (PTX) in this study.
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Objective: An LC-MS/MS Method for Determination of Paclitaxel and Curcumin.

Methods:
The analytes were extracted with methanol, and docetaxel was used as the internal standard
(IS). The analytes and the IS were separated on a C18 (4.6 mm × 50 mm, 3.5 µm) column with a mobile
phase of 0.1% formic acid solution and methanol (80:20, v/v). The flow velocity of the mobile phase
was 0.5 mL/min. And then, the method was applied to study the pharmacokinetic behavior of CUR and
PTX in rats.

Results:
The calibration curves were linear within the concentration ranges of 2–1000 ng/mL for PTX
and 5–500 ng/mL for CUR, the mean extraction recoveries and matrix effects of PTX, CUR, and the IS
were within an acceptable range. The apparent volume of distribution of PTX was different between the
group of administration of PTX and the group of co-administration with CUR and PTX.

Conclusion:
A sensitive and simple liquid chromatography-tandem mass spectrometry method was
established and validated for the synchronous determination of PTX and CUR in rat plasma, CUR increased
the apparent volume of distribution of PTX when CUR and PTX were co-administered.
Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System
Authors: Juarez Juliana M. , Cussa Jorgelina , Gomez Costa Marcos B. , Anunziata Oscar A. 
Published: February 2018

Background:
Controlled drug delivery systems can maintain the concentration of drugs
in the exact sites of the body within the optimum range and below the toxicity threshold, improving
therapeutic efficacy and reducing toxicity.

Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems
due to high biocompatibility, in vivo biodegradability and low toxicity.

Methods:
Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and
loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR,
TGA, TEM and textural analyses.

Results:
We obtained promising results for controlled drug release using the novel MCF material.
The application of these materials in KETO release is innovative, achieving an initial high release
rate and then maintaining a constant rate at high times. This allows keeping drug concentration
within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that
need a rapid response. The release of KETO/MCF was compared with other containers of KETO
(KETO/SBA-15) and commercial tablets.

Conclusion:
The best model to fit experimental data was Ritger-Peppas equation. Other models
used in this work could not properly explain the controlled drug release of this material. The
predominant release of KETO from MCF was non-Fickian diffusion.
Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030
Authors: Bommer Christian , Sagalova Vera , Heesemann Esther , Manne-Goehler Jennifer , Atun Rifat , Bärnighausen Till , Davies Justine , Vollmer Sebastian 
Published: February 2018

OBJECTIVE
Despite the importance of diabetes for global health, the future economic consequences of the disease remain opaque. We forecast the full global costs of diabetes in adults through the year 2030 and predict the economic consequences of diabetes if global targets under the Sustainable Development Goals (SDG) and World Health Organization Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013–2020 are met.

RESEARCH DESIGN AND METHODS
We modeled the absolute and gross domestic product (GDP)-relative economic burden of diabetes in individuals aged 20–79 years using epidemiological and demographic data, as well as recent GDP forecasts for 180 countries. We assumed three scenarios: prevalence and mortality 1) increased only with urbanization and population aging (baseline scenario), 2) increased in line with previous trends (past trends scenario), and 3) achieved global targets (target scenario).

RESULTS
The absolute global economic burden will increase from U.S. $1.3 trillion (95% CI 1.3–1.4) in 2015 to $2.2 trillion (2.2–2.3) in the baseline, $2.5 trillion (2.4–2.6) in the past trends, and $2.1 trillion (2.1–2.2) in the target scenarios by 2030. This translates to an increase in costs as a share of global GDP from 1.8% (1.7–1.9) in 2015 to a maximum of 2.2% (2.1–2.2).

CONCLUSIONS
The global costs of diabetes and its consequences are large and will substantially increase by 2030. Even if countries meet international targets, the global economic burden will not decrease. Policy makers need to take urgent action to prepare health and social security systems to mitigate the effects of diabetes.
Expansion of ologic™ Technology for Eco-Friendly Vehicles
Authors: Kuwayama Isao , Hatanaka Shintaro , Matsumoto Hiroyuki , Saguchi Takanari 
Published: February 2018

ABSTRACT
To realize a substantially eco-friendly tire that simultaneously offers appreciable drivability and traction performance, the authors have developed and proposed a large and narrow tire technology called “ologic” considering size and inflation pressure effects as one of the next-generation tire technologies.
In this study, exclusive technologies in terms of tread pattern and belt construction considering a synergetic effect with compound and separation of lateral/longitudinal stiffness have been developed and evaluated through both numerical simulations and experimental analysis. As a result, appreciable improvements in terms of ologic's advantages have been observed. By using the exclusive technologies, an intermediate size of ologic tires is proposed as well for assisting adoption of ologic tires in the next generation of eco-friendly vehicles with a hope of developing a combined package of tire-suspension system and an ologic tire for making full use of ologic's advantages.
Geographically Weighted Ridge Regression dalam Kasus Multikolinearitas Pada Indeks Pembangunan Manusia di Kabupaten/Kota Provinsi Jawa Timur
Authors: Arthayanti Yani , Srinadi I Gusti Ayu Made , Gandhiadi G.K. 
Published: February 2018

Linear Regression Analysis is a statistical method for modeling relation between two variable, response and explanatory variable. Geograpically Weighted Regression (GWR) is the development of linier regression analysis if the case of spatial divers case. Local multicollinearity is a condition when explanatory variables had correlated with each observation location. Geograpically Weighted Ridge Regression (GWRR) is a method used to model data containing local multicollinearity on spatial data. GWRR model was developed from ridge regression by adding weight as additional information. The study aims to model spatial data containing local multicollinearity to the Human Development Index (HDI) in the districts/municipalities of eastern Java Province in 2015. The result of this study was indicate that the indicator of the average length of school is a dominant indicator that affects HDI.
METODE PENGUKURAN PROBABILITAS KEBANGKRUTAN BANK DAN ANALISIS HUBUNGANNYA DENGAN DIVERSIFIKASI SUMBER PENDAPATAN: KASUS PERBANKAN INDONESIA
Authors: Wibowo Buddi 
Published: February 2018

Abstrak Metode pengukuran probabilita kebangkrutan bank adalah masalah riset klasik. Metode pengukuran menggunakan analisis diskriminan dan model logit seperti Altman’s Z score dan Model Ohlson tidak memiliki dasar teoretik keuangan yang memadai karena variable-variabel yang ada di dalam model dipilih secara arbitrer dan sangat tergantung pada data yang digunakan utuk mengestimasinya. Model Merton adalah model pengukuran probabilita default yang diakui secara luas sebagai model yang memiliki dasar teroretik yang kuat namun memiliki masalah tersendiri pada implementasinya karena variabel yang digunakannya bersifat unobservable. Probabilita default sendiri dipengaruhi oleh tingkat diversifikasi pendapatan bank. Beberapa riset menghasilkan kesimpulan yang bertentangan. Pada perbankan Indonesia hubungan antara kedua variable tersebut bersifat kuadaratik (U shape) dimana diversifikasi yang natural awalnya dapat menurunkan probabilita default bank, namun sampai suatu titik diversifikasi yang terlampau tinggi justru mendorong probabilita default menjadi naik. Kata Kunci: Bank, Risiko, Probabilitas Kebangkrutan, Diversifikasi, Abstract Bank’s probability of default measurement method is one of the classic research problem. The measurement methods using discriminant analysis and logit models such as Altman's Z score and Ohlson Model do not have adequate financial theoretical foundation because variables in the models are chosen arbitrarily and depend heavily on the data used in estimation. Merton’s model of default probability is a measurement model that is widely recognized as a model that has a strong theoretical basis but has its own problems in its implementation because it uses unobservable variables. Default probability itself is influenced by the level of income diversification. Some research resulted in conflicting conclusions. We show that in Indonesian banking industry, relationship between these two variables are quadratic (U shape) which show natural diversification can reduce the bank’s probability of default, until reach a infelction point that too high diversification would encourage the probability of default to be increased Key word: Bank, Risk, Probability of Default, Diversification
La Geografía y su enseñanza en el ámbito escolar
Authors: Naranjo Villa Laura , Aguirre Marco Antonio , Muñoz Escobar Jeniffer 
Published: February 2018

Actualmente, la enseñanza de la geografía escolar en Colombia ha venido presentando una serie de vacíos que permiten establecer fracturas o dicotomías entre la geografía de carrera, propia del ámbito universitario, con respeto a la geografía escolar y su enseñanza. En ese contexto, algunos académicos han identificado tales falencias asociadas, primero, al tipo de formación profesional que reciben los docentes, segundo, que los encargados de elaborar mallas curriculares consideran poco relevante las temáticas de geografía, y tercero, la débil cohesión entre campos de investigación, la geografía escolar y la geografía académica. En este sentido, este artículo pretende mostrar la disyunción entre la enseñanza de la geografía escolar y la geografía de carrera, a partir de una revisión bibliográfica a nivel nacional validado a través de trabajo en campo realizado con seis docentes encargados del área de ciencias sociales de tres instituciones educativas de la ciudad de Santiago de Cali a quienes se entrevistó con el fin de conocer los conceptos desarrollan en clase, sus metodologías y dificultades a la hora de enseñar geografía. Este trabajo permitió no sólo identificar vacíos, además de establecer posibilidades metodológicas para interrelacionar la geografía universitaria con la geografía escolar.
Secukinumab Provides Complete or Almost-Complete Psoriasis Clearance in Moderate-to-Severe Plaque Psoriasis: Pooled Analysis of 4 Phase 3 Trials
Authors: Blauvelt A , Armstrong A , Rich P , Kisa R , Guana A , Meng X , Callis Duffin K 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN
Certolizumab Pegol for the Treatment of Patients with Moderate-to-Severe Chronic Plaque Psoriasis: An Overview of 3 Randomized Controlled Trials
Authors: Blauvelt Andrew , Reich Kristian , Lebwohl Mark , Burge Daniel , Arendt Catherine , Peterson Luke , Rolleri Robert , Gottlieb Alice 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by UCB Pharma. Copyright 2018 SKIN
The Efficacy and Safety of FMX101, Minocycline Foam 4%, for the Treatment of Acne Vulgaris: A Pooled Analysis of Phase 2 and Phase 3 Studies
Authors: Stein Gold Linda , Dhawan Sunil , Weiss Jonathan , Draelos Zoe D , Ellman Herman 
Published: February 2018

Abstract not available.Disclosures: Study supported by Foamix Pharmaceuticals, Inc.Copyright SKIN 2018
Early Onset of Efficacy Using a 1% and 2% Topical Minocycline Gel for the Treatment of Rosacea: a Small Open Label Study
Authors: Bhatia N , Ahmadyar M , Hansra H , Del Rosso J , Baldwin H , Daniels AM 
Published: February 2018

Abstract not available. Disclosures: Study supported by BioPharmX, Inc. Copyright SKIN 2018
Open-Label Study (ARIDO) Evaluating Long-Term Safety of Topical Glycopyrronium Tosylate (GT) in Patients with Primary Axillary Hyperhydrosis
Authors: Glaser Dee Anna , Hebert Adelaide A , Nast Alexander , Werschler William P , Shideler Stephen , Green Lawrence , Mamelok Richard D , Drew Janice , Quiring John , Pariser David M 
Published: February 2018

Abstract not available. Disclosures: Study supported by Dermira, Inc. Copyright SKIN 2018
"CSTC T-PPR": ARCHITECTURAL AND HISTORICAL DEVELOPMENT OF ODESSA IN ХІХ ... THE BEGINNING OF THE XX-th CENTURIES
Authors: Posternak I. , Posternak S. 
Published: February 2018

It is offered to create in the city of Odessa "the Corporate scientific and technical complex town-planning power reconstruction "CSTC T-PPR", as innovative organizational structure which uses in practice the saved up scientific and technical potential for reconstruction of buildings of historical building of Odessa under standards power efficiency. It is executed researches of historically-style development which is characterized by the big scope of civil work and presence of various styles. Superstructures were carried out in a city practically during all history its development. The mansard floor is an effective variant a superstructure buildings of background building. Пропонується створити у місті Одесі "Корпоративний науково-технічний комплекс містобудівної енергореконструкції "КНТК МЕРек", як інноваційну організаційну структуру, яка використовує на практиці накопичений науково-технічний потенціал для реконструкції будівель історичної забудови Одеси за стандартами енергоефективності. Виконано дослідження історично-стильового розвитку Одеси в ХІХ … на початку ХХ століть, який характеризується великим розмахом будівельних робіт та наявністю різноманітних стилів (класицизм, бароко, романтизм, конструктивізм). Враховуючи, що розташування нового будинку в щільному ряду історичної забудови заборонено, то виходом з такої ситуації є надбудова будівлі новим об'ємом. Надбудови виконувалися в місті практично в ході всієї історії його розвитку. Ефективним варіантом надбудови будівель фонової забудови є мансардний поверх.
Vergi Yükü Ekseninde Toplumsal Yapının Gelir Dağılımı ve Yoksullukla İlişkisi
Authors: Ay Hakan , Haydanlı Mehmet Lalif 
Published: February 2018

Vergi
yükü kavramı; bir ülkenin gelişmişlik göstergelerinden biri olduğu kadar, kamu
ekonomisinin milli ekonomi içerisindeki payını göstermesi bakımından da
anlamlıdır. Çünkü özelikle gelişmekte olan ülkelerde büyük sermaye gerektiren
altyapı yatırımları, özel tasarrufların istenilen düzeyde olmaması ve buna
paralel seyreden kamu hizmetlerinin niteliği ve ulaşılabilirliği vergi yükü kavramının
önemini ortaya koyan argümanlardır. Bir ülkede vergi yükünün hangi toplum
kesimleri tarafından yüklenildiği, o toplumun vergi yapısı, gelir dağılımı gibi
faktörler, eşitlik ve adalet gibi kavramların ışığında istatistiki verilerle
ortaya konmaya çalışılmaktadır. Yoksulluk ve yoksunluk, sosyal dışlanma gibi
sosyolojik yaklaşımlar, küreselleşme kıskacındaki günümüz bireylerinin sosyal
hak ve özgürlükleri bağlamında modern devletlerin ekonomi politikalarını
etkileyen kavramlar olmuştur.

Vergi yapısı bir ülkenin
tasarruf hacmini doğrudan etkilemektedir. Bu durum; ülkenin ekonomik
gelişmişliğini göstermesi bakımından anlamlı sonuçlar ortaya koymaktadır. Bugün
sosyal bir sorun olarak karşımıza çıkan yoksulluk ise, Avrupa kapitalizminin
ortaya çıkışıyla başlamaktadır. Modern yoksulluk; işbölümünün artması ve
istihdamın dengesiz ve düzensiz bir seyir izlemesi, topraktan kopan kırsal
kesim insanının düzensiz şehirleşmeyi artırması ve sosyal ilişkilerin bozulması
yeni bir yoksulluk olarak ortaya çıkmıştır. Aynı durum uluslararası bir sorun
olarak karşımıza çıkan mülteci çıkmazıyla da bağlantılıdır. Bunun neticesinde
ise ülkelerin maliye politikaları ile ekonomiye müdahalede bulunmaları zorunlu hale
gelmiştir.
Finance et néolibéralisme
Authors: Askenazy Philippe 
Published: February 2018

Cet article explore les interactions entre le néolibéralisme et le développement de la finance – industrie financière, financiers – comme vecteur des inégalités de revenus primaires comme secondaires. Alors que la montée des inégalités devrait rendre politiquement insoutenables les politiques néolibérales qui les exacerbent, la Finance appréhendée au sens large – secteur financier et activités associées, financiarisation, financiers – vient en support du néolibéralisme. Jusqu’à la chute de Lehman Brothers, la finance a accompagné l’extension du néolibéralisme, par les emplois qu’elle concentrait chez les premiers pays convertis, puis par l’innovation financière permettant notamment l’accès à la propriété au plus grand nombre. Depuis 2008, elle endosse le rôle du coupable qui imposerait l’accentuation des réformes néolibérales, parce qu’elle l’exigerait soit en tant que créancier des États, soit en tant qu’intermédiaire de citoyens attachés à leur épargne retraite, soit, dans le cas de l’Europe continentale, comme opportunité industrielle post-brexit. Classification JEL : B22, G1, G2, H50 .
Contribution du patrimoine à la formation des inégalités
Authors: Carbonnier Clément 
Published: February 2018

Cet article documente les liens entre la constitution des patrimoines et plusieurs types d’inégalités. Les inégalités des patrimoines eux-mêmes, tout d’abord, sont très fortes et en croissance. Les différences d’opportunités de placements selon la taille des patrimoines génèrent des rendements globalement croissants avec la taille du patrimoine, ce qui accentue encore la dynamique des inégalités. Dans ce sens, l’augmentation rapide de la valeur du patrimoine immobilier et la baisse des rendements de ces types de placement sont un vecteur majeur de la croissance des inégalités de patrimoine, en sus des problèmes de logement qu’elles engendrent. Cela rejoint la question de la croissance des inégalités de revenus, dans lesquels les revenus du patrimoine, extrêmement concentrés, jouent un rôle très important. Apparaît également la question de la persistance des inégalités, avec la part croissante que prennent les héritages dans les revenus et la constitution des patrimoines. Classification JEL : D3, D31, D63, G2 .
Sortir les banques des paradis fiscaux
Authors: Chavagneux Christian 
Published: February 2018

Les scandales fiscaux à répétition (Panama et Paradise Papers, etc.), les informations qu’elles doivent publier ainsi que de récentes études académiques démontrent combien les banques entretiennent une relation étroite avec les paradis fiscaux. Elles les utilisent pour elles-mêmes et s’y inscrivent comme intermédiaires au service des utilisateurs de ces territoires. Au-delà des aspects fiscaux, les activités qu’elles y développent nourrissent l’instabilité financière internationale. Au service des acteurs les plus puissants (particuliers et entreprises), elles contribuent au renforcement des inégalités. Classification JEL : D3, G21, F65, H26.
Vers un militantisme virtuel ? Pratiques et engagement féministe sur Internet
Authors: Weil Armelle 
Published: February 2018

C’est depuis les années 1990 que les plateformes numériques sont saisies par les milieux militants, notamment féministes, comme outil et lieu de recrutement, mais aussi comme mode d’action. L’impact du web sur le mouvement féministe questionne : révélerait-il une nouvelle forme de militantisme et de nouvelles pratiques ? S’appuyant sur une recherche exploratoire qui étudie des blogs et des groupes Facebook, cet article cherche à saisir certaines caractéristiques des féminismes virtuels. Après avoir décrit les modes d’entrée actuels dans le mouvement, l’auteure s’intéresse aux actions virtuelles comme performances, aux objectifs et aux idéaux qui les fondent, ainsi qu’au sens de l’engagement sur le web. Elle analyse ainsi le potentiel militant d’Internet, un militantisme qui, en définitive, s’inscrit plus dans la continuité du mouvement féministe des années 1970 que dans une rupture technologique.
Le chômage : un problème de santé publique majeur
Authors: Meneton Pierre , Plessz Marie , Courtin Émilie , Ribet Céline , Goldberg Marcel , Zins Marie 
Published: February 2018

Les études disponibles dans plusieurs pays et les quelques données obtenues récemment en France suggèrent que les conséquences du chômage sur la santé vont bien au-delà de l’augmentation de la fréquence des suicides. L’incidence des pathologies chroniques, maladies cardiovasculaires et cancers en premier lieu, semble également fortement augmentée chez les chômeurs par rapport aux travailleurs. Les mécanismes par lesquels le chômage est susceptible de dégrader l’état de santé sur le long terme sont encore à éclaircir : exposition accrue à des facteurs de risque comportementaux, accès réduit au système de soins, effets organiques plus directs sont autant de pistes possibles. D’ores et déjà, il serait souhaitable que le corps médical soit sensibilisé sur les risques encourus par les chômeurs afin de les aider à les réduire autant que faire se peut.
Réformes managériales et redéfinition des catégories d’action publique : l’exemple du secteur médico-social
Authors: Coron Gaël 
Published: February 2018

L’article analyse les évolutions du secteur médico-social au regard des transformations contemporaines de l’action publique qui ont justement comme effet de réduire les particularités des secteurs de politique publique. Après avoir rappelé la difficulté d’identifier le médico-social comme objet spécifique, trois scenarii sont évoqués pour son avenir : une forte réduction de son autonomie, un rapprochement fort avec le secteur sanitaire et la réaffirmation de son autonomie à travers la construction en cours d’un discours endogène. Chacun de ces scenarii s’appuie sur une analyse des évolutions récentes des politiques médico-sociales.