bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian Islamic Law Review on the Marriage Customs of Juelen and Angkap in Gayo Tribes, Central Aceh District
Authors: Mulyadi Mulyadi , Asmuni Asmuni , Sukiman Sukiman 
Published: May 2019

This study presents the latest information on a review of Islamic law towards marriage customs of juelen and angkap in Gayo tribe, Central Aceh District. This research uses the theory of mashlahah: the applicative theory is used in analyzing the research data and in the end of the research shows that the effect of marriage custom of Gayo on juelen and angkap must continue to give part to each party (ex-husband and wife) especially the marriage of Angkap, and if there is a dowry debt as in marriage of angkap, then it can be settled after sharing of shared assets between the former wife and husband. This awarding is based on consideration of mercy on the basis of providing guarantees in life after the divorce occurred. Obviously by giving a share to the husband or wife of shared assets as a result of the marriage customs of juelen / angkap in Gayo custom, it is still based on the idea behind the spirit of KHI that seeks to translate shared assets as a means to guarantee life after divorce and of course this is in line with the legal basis Islam. Thus, the formulation of article 85-97 KHI is considered to fulfill the values of benefit in maintaining humanitarian relations and the benefit of family.
Evaluation of Prophylactic Effect of Intramuscular Diclofenac Sodium for Prevention of Succinylcholine-Induced Myalgia
Authors: Hossain Muhammad Sazzad , Rahman Md Afzalur , Islam Syed Ariful , Waliullah Md 
Published: May 2019

Background: Succinylcholine a depolarizing muscle relaxant with rapid onset, predictable course and short duration of action is associated with myalgia.
Objectives: To assess the efficacy of intramuscular injection of diclofenac sodium in preventing succinylcholine-induced myalgia.
Materials and Methods: Eighty healthy adults scheduled for elective surgery under general anesthesia were enrolledin a double-blind study and randomly allocated into two groups of forty patients. Patients in Group I (diclofenacgroup) were pretreated with inj. diclofenac 75 mg deep intramuscularly into gluteal region one hour prior to induction of anesthesia, while patients in Group II (saline group) received an equivalent volume of saline inj. in same site. Anesthesia was induced in both groups with fentanyl 1.5 mcg/kg, propofol 2.0 mg/kg and succinylcholine1.5 mg/kg. Postoperative myalgia was assessed 24 hours after induction and graded as nil, mild, moderate, or severe.
Results:The demographic data for both groups were comparable (p > 0.05). Postoperative myalgia was recorded at 24 hours after induction in diclofenac group with twelve (30%) patients and 24 (60%) patients in normal saline (control) group respectively (p < 0.05). Conclusion: Prophylactic use of intramuscular injection of diclofenac is effective in the prevention of postoperative myalgia
KYAMC Journal Vol. 10, No.-1, April 2019, Page 35-38
Effect of Atorvastatin and Losartan on Glomerular Filtration Rate in Patients With Mild to Moderate Chronic Kidney Disease
Authors: Khan Md Moniruzzaman , Dewan Zesmin Fauzia , Rahman AKM Shahidur , Nomany Bakhtiare Md Shoeb , Mir Ahmed Salam , Haider Mohammad Zahid 
Published: May 2019

Background: Atorvastatin, a member of HMG CO-A reductase inhibitors, has been shown to have renoprotective effect in patients with Chronic Kidney Disease (CKD). Statins are supposed to decrease the oxidized lipid particles, suppress the activity of inflammatory mediators and prevent vascular thrombosis and thus could minimize renal cell damage. Losartan, an antihypertensive drug also diminishes proteinuria in patients with chronic kidney diseases or diabetes mellitus. Therefore the effect of concurrent use of atorvastatin and losartan on Glomerular Filtration Rate (GFR) could be a matter of interest from both Pharmacological and Clinical perspective.
Objective: To assess the renoprotective effect of atorvastatin and losartan in patients with chronic kidney disease treated at Bangabandhu Sheikh Mujib Medical University (BSMMU).
Materials and Method: Total forty four (44) patients suffering from CKD (stage one to stage three) were enrolled into two groups. Patients in Group A, received atorvastatin (10 mg) and losartan (50 mg) once daily for eight weeks. Patients in Group B, received losartan but not atorvastatin for the same duration. Serum creatinine level was measured at the commencement and also after eight weeks to calculate estimated glomerular filtration rate (eGFR) in individual patients with MDRD (Modification of Diet in Renal Disease) study equation.
Results: There was significant (P < 0.001) reduction of Serum Creatinine and significant (P < 0.001) increase in e GFR in the patients, treated with atorvastatin and losartan.
Conclusion: Concurrent administration of atorvastatin and losartan increased glomerular filtration rate (GFR) significantly in patients with chronic kidney disease.
KYAMC Journal Vol. 10, No.-1, April 2019, Page 43-47
Assessment of paddy harvesting practices of Southern Delta Region in Bangladesh
Authors: Hasan MK , Ali MR , Saha CK , Alam MM , Hossain MM 
Published: May 2019

Paddy in Bangladesh is an important cereal crop for national food security. Harvesting is the process of collecting mature paddy from the field. Timely harvesting operation is known as crucial and influential processes on quantity, quality and production cost of paddy. The aim of the study was to assess the manual and mechanical harvesting systems of paddy in southern delta region of Bangladesh in terms of labor cost, infield harvesting losses, and time required for harvesting. Several experiments were conducted to compare mechanical and manual harvesting systems. Mechanical harvesting of Aman paddy (November-December 2016) and Boro paddy (April-May 2017) was conducted using two models of reaper and a mini-combine harvester at Dumuria and Wazirpur Upazilas of Khulna and Barisal districts, respectively. An experiment was also conducted at the same locations to determine labor requirement and time for harvesting paddy manually. To determine manual harvesting loss, an experiment was conducted at BAU farm, Mymensingh. Total cost savings in paddy harvesting were found 52% and 37% for mini-combine harvester and reaper, respectively over manual harvesting system. Similarly, labor savings using mini-combine harvester and reaper were found 65% and 52%, respectively over manual harvesting system. The total harvesting losses (including harvesting, threshing and cleaning) were also found 1.24%, 4.22% and 6.36% for using mini-combine, reaper and manual harvesting systems, respectively. The results indicated that manual harvesting is a slow and cost involving system. On the other hand, lack of awareness among farmers about the benefits of mechanical harvesting system and lack of skill manpower for operating and servicing harvesters are major barriers for adopting mechanized harvesting system in southern delta region. This study revealed that mechanical harvesting of paddy using either reaper or mini-combine harvester will assist to strengthen food security in southern delta of Bangladesh.
Progressive Agriculture, Vol. 30, Suppl. 1: 57-64, 2019
Prevalence of Cervical Intra Epithelial Neoplasia (CIN) among the Sexually Active Married Women by Colposcopy at Rajshahi Division
Authors: Jesmin Sahela , Najnin Monira , Ashrafunnesa - , Afroz Romana , Sarkar Mousumi , Shamima Mosammat Nargis 
Published: May 2019

Objective: To determine the prevalence of cervical intra epithelial neoplasia (CIN) among sexually active married women in Rajshahi division of Bangladesh. Study Design: It is a prospective cross sectional type descriptive study.
Place and Duration: This study is population based & carried out in 4 selected Upazilla from 4 different districts of Rajshahi Division. Total 1050 patient were enrolled in the study. Study period was 6 months from 1st December 2014 to 31st May 2015. Subject and Method: All sexually active woman between age group 25 to 55 years in selected Upazilla. In UHC of preselected Upazilla who fulfilled the inclusion criteria enrolled in the study after taking the consent. Frequency & risk factors for CIN were analyzed after entering in predesigned proforma.
Result: During study period of 6 months among 1050 enrolled patients 90 patient were VIA positive and 91 patients were colposcopically abnormal and among these 33 patients were CIN positive & 58 patients had chronic cervicitis with or without squamous metaplasia. Mean age of CIN positive were 36.75 years, 92.2% patient were housewife & 7.8% patient were service holder and in 64.6% patients education level up to XII class, in 55.5% patients husband was day labour from poor socioeconomic condition.
Conclusion: VIA and Colposcopy can differentiate a normal cervix from a precancerous cervix with reasonable accuracy. Till now, a good number of studies had been carried out in different countries of world & it is now well established that sensitivity of the test is very good. From the present study we can conclude that it will give very good information about the prevalence of CIN in our country and by follow up study this might help us in reducing the incidence of carcinoma cervix.
TAJ 2018; 31(2): 1-5
Effect of Combined Medical and Surgical Induction of Labour in Term Pregnancy at Rajshahi Medical College Hospital
Authors: Lovely Nur A Atia , Islam AHM Tohurul , Ali Obaidullah Ibne , Khatun Rokeya 
Published: May 2019

This prospective clinical study was conducted in the Department of Obstetrics & Gynaecology in Rajshahi Medical College Hospital from January to December 2007. A total sample of about 100 selected primigravid women were divided into two groups. Group-I was given medical induction by misoprostol orally and Group-II by oral misoprostol followed by artificial rupture of membrane (ARM) for induction of labour. This study specifically evaluated the effect of oral misoprostol and the combined medical & surgical method, on unripe cervix of primigravid women with term pregnancies and has shown that combined method can successfully initiate labour and also lower the rate of caesarean section and significantly lowering the induction delivery time.
TAJ 2018; 31(2): 17-20
Thyroid Peroxidase Antibody among Hypothyroid Patients and Clinical and Biochemical Response to L-Thyroxine Replacement Therapy
Authors: Debnath Asish Kumar , Haque Md Azizul , Bhattachyaria Partho Moni , Islam Quazi Tarikul , Ekram ARM Saifuddin 
Published: May 2019

This study was carried out in the Department of Medicine, Rajshahi Medical College, in 2006-2007 to study the thyroid peroxidase (TPO) antibody level among hypothyroid patients and to find out the effects of L-thyroxine therapy in TPO-antibody titer. After thorough physical examination and relevant investigations, 100 patients of hypothyroidism were enrolled in this study. The selected patients were given L-thyroxine replacement therapy at a dose of 50-150 microgram/d. Before starting L-thyroxine, serum was collected from all patients to estimate anti TPO-antibody level. All patients were followed-up after 12-28 weeks of full dose of L-thyroxine therapy. Patients with high TPO-Abs at baseline, only 17.6% turned into euthyroid (based on composite clinical score), whereas about 42% of the patients who did not have high TPO-Abs became euthyroid suggesting that patients with high TPO Abs may show significantly poor response to treatment compared to the patients without high TPO Abs (p < 0.001). Patients with high TPO-Ab titers also showed a decreased biochemical response (TSH values) compared to the patients without high TPO-Ab positive patients. So, TPO-Ab plays a significant role in causation of the disease and is also associated with poor treatment response with L-thyroxine replacement therapy.
TAJ 2018; 31(2): 45-49
Serum Electrolyte Profile of Children Less Than Five Years of Age Admitted with Pneumonia in a Tertiary Care Hospital
Authors: Kamal Abu Hena Mostafa , Afrozy Sharmin , Khatun Marjina , Nawrozy Mst Shaheen , Akhter Most Merina 
Published: May 2019

The study was done to observe whether there is any association of pneumonia with hyponatraemia, as well as to have a view to the patients’ hospital-stay in this regard. This study was conducted from July 2009 to September 2011 at the Department of Biochemistry of Shaheed Ziaur Rahman Medical College (SZMC), Bogra. Total 35 cases, 1 month to 5 years of age, who suffered from pneumonia, were included in this study. Their serum Na+, K+& Cl- levels were measured and their hospital stays in days were recorded for the comparison between normonatraemics and hyponatraemics. The distribution patterns were described as percentage of total. In addition, Student’s ‘t’ test and Pearson’s correlation co-efficient test were also used. Among 35 cases, 22 (63%) cases were male and 13 (37%) cases were female; 14 (40%) cases were hyponatraemic and 21 (60%) cases were normonatraemic. Mean (±SD) of age was 19.6 (±15.2) months. For all the cases, there was a positive correlation of serum Cl– with serum Na+ levels (p<0.001); but no correlation was observed between serum K+& Na+ levels (P>0.10). Hospital stay of hyponatraemic cases was higher than the normonatraemic cases (P<0.05). Children with pneumonia may develop hyponatraemia, which if not managed in due time, may lead to delayed recovery from illness.
TAJ 2018; 31(2): 59-62
Development and Validation of Tadalafil Determination in Human Plasma by HPLC-MS Method
Authors: Bogdanova D. S. , Komarov T. N. , Shohin I. E. , Melnikov E. S. , Miskiv O. A. , Medvedev Yu. V. 
Published: May 2019

Introduction. Tadalafil is a drug used to treat erectile dysfunction. For the quantitative determination of tadalafil in human plasma are used methods of high performance liquid chromatography with ultraviolet and tandem mass spectrometric detection, during the analytical part of pharmacokinetic studies. In the majority of the considered methods the method of liquid-liquid extraction and the method of solid-phase extraction are used, these methods are difficult and expensive. Therefore, the method of protein precipitation was considered as sample preparation. This method is simple and there is important to analysis a lot of clinical samples in bioequivalence studies.Aim. The aim of this study is to develop method for the quantitative determination of tadalafil in human plasma by HPLC-MS for the analytical part of pharmacokinetic studies.Materials and methods. Quantitative determination of tadalafil in plasma by HPLC-MS. A sample was prepared using acetonitrile protein precipitation.Results and discussion. This method was validated by next validation parameters: selectivity, matrix effect, calibration curve, accuracy, precision, lower limit of quantification, carry-over and stability.Conclusion. The method of the quantitative determination of tadalafil in human plasma was developed and validated by HPLC-MS. The analytical range of the was 5,00–1000,00 ng/ml tadalafil in plasma. Method could be applied to determination of tadalafil in plasma for PK and BE studies.
Synthesis, Acaricidal, Bacteriostatic Activity Among the Amino Derivatives 5,7-Dichloro-4,6-Dinitrobenzofuroxana
Authors: Spatlova L. V. 
Published: May 2019

Introduction.In recent years, interest in the compounds of the benzofuroxane series has increased, because they have a wide range of biological activity, and in addition are donors of nitric oxide. In the scientific literature, many works are related to the synthesis and study of the biological activity of 5-nitro-4,6-dichlorobenzofuroxane amino derivatives, whereas amino derivatives of the 5,7-dichlor-4,6-dinitrobenzofuroxane substrate have been poorly studied.Aim.Is the synthesis of new amino derivatives of 5,7-dichloro-4,6-dinitrobenzofuroxane and the study of their biological activity.Materials and methods.Investigated the reaction of condensation of 5,7-dichloro-4,6-dinitrobenzofuroxane with different aromatic amines, containing functional groups of acceptor character in their structure were selected. In order to increase the yield for each specific reaction, the reaction conditions were selected (the reaction temperature, medium, and the amount of amine). The structure of the compounds confirmed IR, NMR spectra and elemental analysis.Results and discussion.New compounds in the 5,7-diamino-4,6-dinitrobenzofuroxane series were obtained. Acute toxicity, acaricidal and bacteriostatic activity against Escherichia coli and Staphylococcus aureus were studied. The obtained compounds were found to have high pharmacological activity, superior to the comparison drug (Chlorophos and Creolin).Conclusion.Most of the amino derivative synthesized 5,7-dichloro-4,6-dinitrobenzofuroxane have a high activity against mites and bacteria. Compounds containing in their structure chlorine and methyl radicals, have biological activity at low concentrations, are low-toxic and belong to the 4th hazard class.
Validation of Analytical Procedures: Graphic and Calculated Criteria for Assessment of Methods Linearity in Practice
Authors: Epshtein N. A. 
Published: May 2019

Introduction. «Linearity» is one of the required characteristics when validating analytical procedures. The issues of the validation of linearity procedures are still relevant.Aim. To consider the main graphical and calculated criteria for confirmation of the linearity of analytical procedures and their restrictions, as well as to give recommendations.Materials and methods. Statistical calculations were performed using MS Excel. Experimental data were obtained by HPLC.Results and discussion. The main criteria for proving/confirming the linearity of analytical procedures and their restrictions are considered in detail. It is shown that these criteria cannot always give a reliable assessment of the linearity of the procedure, the possible reasons for this are indicated and recommendations are given.Conclusion. When validating the procedures, it is necessary to prove/confirm their linearity by using two, and, more reliably, three criteria, one of which must be the linearity of the plot of measured response (Y) vs concentration of the tested substance (C). On the other hand, we demonstrate here that a formal approach should not be used for the estimation of non-linearity of the procedure when using graphical and calculation criteria based on mathematical statistics, since they do not take into account the possibility of practical insignificance of small deviations from the linear dependence of Yon C.
Study of Desorbtion and Exemption of Terpeno-indole Alkaloids of Vinkristin and Vinblastin from Erythrocitary Cell Carriers
Authors: Trineeva O. V. , Khalahakun A. D. 
Published: May 2019

Introduction. Employees of the Department of Pharmaceutical Chemistry and Pharmaceutical Technology have obtained modified forms of terpino-indole alkaloids (ТIA) and vinbristine (VCR) and vinblastine (VBL) known in the treatment of cancer diseases by incorporating them into the erythrocyte carriers (EN) by the modified method of hypoosmotic lysis in the modified (aprotic solvent dimethyl sulfoxide (DMSO) and polyethylene glycol (PEG 4000) and unmodified media.Aim. The aim of the work was to study the desorption and release of terpene-indole vincristine and vinblastine alkaloids from previously obtained cellular erythrocyte carriers.Materials and methods. In the experiment performed, the release characteristics of encapsulated preparations from erythrocytes were determined. TIA preparations were released from erythrocyte form in 6 hours: VCR – 54.5305%, VCR : PEG-4000 (1:5) – 53.3305%, VCR : PEG-4000 (1:10) – 40.1283%, VCR : PEG-4000 (1:20) – 39.9869%, VCR : DMSO (2 mg/ml) – 54.2354%, VBL – 68.0656%; VBL : PEG-4000 (1:10) – 63.8941%; VBL : PEG-4000 (1:20) – 60.7455%; VBL : PEG-400 (1:20) – 60.3529%; VBL : DMSO (2 mg/ml) – 64.5006%. The rate of release from an erythrocyte form encapsulated in a medium modified with DMSO is significantly higher than that encapsulated in an unmodified medium. The average rate of TIA release from erythrocyte forms encapsulated in PEG medium is approximately the same.Results and discussion. The results show that the release of hemoglobin from TIA encapsulated erythrocytes compared with non-encapsulated EN is small. The results show that, on average, 8.242 ± 0.3135% of hemoglobin is released from TIA encapsulated with EN, compared to control erythrocytes – 7.53% after 6 h of incubation at 37 °C. The release of hemoglobin from the TIA of encapsulated erythrocytes in modified media is less than that encapsulated in unmodified medium.Conclusion. Based on these results, it can be suggested that PEG can bind to the erythrocyte membrane and stabilize it.
Study of Morphology of Sorption Substances
Authors: Bondarev A. V. , Zhilyakova E. T. , Demina N. B. , Novikov V. Y. 
Published: May 2019

Introduction. Substances with sorption properties can be used to create transport drug systems, in which the main mechanism of binding, transport and release of the drug molecule is sorption. The sorbent in this case acts as a carrier of the drug molecule, followed by its delivery to the destination by desorption. One of the ways to study the processes of sorption-desorption in transport drug systems is the study of the morphology of the sorption substance. Therefore, the morphological analysis of sorption substances is important, including the size, shape, and spatial organization of their structural elements.Aim. The study of the morphology of sorption substances.Materials and methods. The materials of the study are active coal, silicon dioxide, povidone, dioctahedral smectite, kaolin and montmorillonite clay. The methods is scanning electron microscopy.Results and discussion. The scanning electron microscopy of objects was carried out using segmentation of elements as subsystems, inside of which the morphological description does not penetrate. It was established that for coal of active and silicon dioxide, the segmentation of elements is represented by three levels of organization; for povidone, smectite, kaolin and montmorillonite clay, the segmentation of elements is represented by two levels of organization. The morphology of the objects was investigated. It is established that the studied substances are microstructural objects. Porosity in samples of active coal, smectite dioctahedral, kaolin, montmorillonite clay was determined. In samples of silicon dioxide and povidone porosity is absent.Conclusion. Morphological analysis of sorption substances allowed us to develop classification of the possible interaction of the carrier substance with the drug molecule in the transport drug system. The materials under study are divided into two groups according to porous characteristics: group 1 – porous substances – sorption interaction in pores (active coal), sorption interaction in pores and by ion exchange (smectite, montmorillonite clay), sorption in secondary pores and through oxygen and hydroxyl centers (kaolin); group 2 – non-porous substances – sorption on oxygen centers (silicon dioxide), sorption by means of complex formation (povidone). The prospect of further research is the modeling of porosity and sorption interaction of the carrier substance with the drug molecule in the drug transport system.