bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage
Authors: Piña Ricardo , Ugarte Gonzalo , Campos Matías , Íñigo-Portugués Almudena , Olivares Erick , Orio Patricio , Belmonte Carlos , Bacigalupo Juan , Madrid Rodolfo 
Published: August 2019

The cornea is extensively innervated by trigeminal ganglion cold thermoreceptor neurons expressing TRPM8 (transient receptor potential cation channel subfamily M member 8). These neurons respond to cooling, hyperosmolarity and wetness of the corneal surface. Surgical injury of corneal nerve fibers alters tear production and often causes dry eye sensation. The contribution of TRPM8-expressing corneal cold-sensitive neurons (CCSNs) to these symptoms is unclear. Using extracellular recording of CCSNs nerve terminals combined within vivoconfocal tracking of reinnervation, Ca2+imaging and patch-clamp recordings of fluorescent retrogradely labeled corneal neurons in culture, we analyzed the functional modifications of CCSNs induced by peripheral axonal damage in male mice. After injury, the percentage of CCSNs, the cold- and menthol-evoked intracellular [Ca2+] rises and the TRPM8 current density in CCSNs were larger than in sham animals, with no differences in the brake K+currentIKD. Active and passive membrane properties of CCSNs from both groups were alike and corresponded mainly to those of canonical low- and high-threshold cold thermoreceptor neurons. Ongoing firing activity and menthol sensitivity were higher in CCSN terminals of injured mice, an observation accounted for by mathematical modeling. These functional changes developed in parallel with a partial reinnervation of the cornea by TRPM8(+) fibers and with an increase in basal tearing in injured animals compared with sham mice. Our results unveil key TRPM8-dependent functional changes in CCSNs in response to injury, suggesting that increased tearing rate and ocular dryness sensation derived from deep surgical ablation of corneal nerves are due to enhanced functional expression of TRPM8 channels in these injured trigeminal primary sensory neurons.SIGNIFICANCE STATEMENTWe unveil a key role of TRPM8 channels in the sensory and autonomic disturbances associated with surgical damage of eye surface nerves. We studied the damage-induced functional alterations of corneal cold-sensitive neurons using confocal tracking of reinnervation, extracellular corneal nerve terminal recordings, tearing measurementsin vivo, Ca2+imaging and patch-clamp recordings of cultured corneal neurons, and mathematical modeling. Corneal nerve ablation upregulates TRPM8 mainly in canonical cold thermoreceptors, enhancing their cold and menthol sensitivity, inducing a rise in the ongoing firing activity of TRPM8(+) nerve endings and an increase in basal tearing. Our results suggest that unpleasant dryness sensations, together with augmented tearing rate after corneal nerve injury, are largely due to upregulation of TRPM8 in cold thermoreceptor neurons.
How Did J. S. Bach’s “Aus Liebe will mein Heiland sterben,” BWV 244/49, Get to Be So Slow?
Authors: Melamed Daniel R. 
Published: August 2019

A high point of almost every performance of J. S. Bach’s St. Matthew Passion is the tragic and time-stopping aria “Aus Liebe will mein Heiland sterben,” BWV 244/49. It appears to make sense in context, but commentators have long wondered how Bach and his librettist could have reused such somber music in the so-called Cöthen Funeral Music, BWV 244a, with a new text that opens “Mit Freuden sei die Welt verlassen”; the invocation of joy apparently represents a strong contradiction in affect with the music, almost uniformly understood to be very slow.
The slow tempo did not originate with Felix Mendelssohn, who included the aria in his second performance of the Passion in 1841. The aria’s character appears to have been established later in the nineteenth and early twentieth centuries in critical writings that regarded it as transcendent and representative of the Passion’s supposed pure tragedy. The aria arguably came to be seen as the St. Matthew Passion’s transcendent “slow movement,” a much-venerated instrumental type. Its character was codified in influential nineteenth-century editions that assigned slow tempo and metronome markings, and the recorded history of the work documents very slow tempos, only recently moderated. Adaptations of the aria have taken it to be very slow as well, and represent readings of the received performance tradition of the work. The aria’s doctrinal and affectively neutral text and its musical construction suggest the plausibility of a much faster tempo. And this, in turn, could explain why it occurred to Bach and his librettist Picander to reuse it for a text that begins with the concept of joy. The slow tempo of “Aus Liebe” and the problem of its reuse with a very different text turn out to be an inheritance from the nineteenth-century reception of the work.
Association of Iron Pills Consumption during Pregnancy with Incidence of Maternal Anemia in Indonesia (IFLS 5 Advanced Analysis Study)
Authors: Iswardani Octaldina , Hakimi Mohammad , Kurnia Arif Rahmat 
Published: August 2019

Background: Indonesia Family Life Survey (IFLS) data in this study focused on the consumption of iron pills (Fe) during pregnancy and maternal anemia in Indonesia (Study analysis continued IFLS 5). The aim of this research is knowing the relationship of consumption of iron pills during pregnancy with the incidence of maternal anemia in Indonesia.
Methods: Study was an observational analytic study with a cross sectional design using IFLS 5 data which taken in 2014-2015.
Results: From the results of multiple logistic regression tests, the variables of education, mother’s residence and history of bleeding at delivery were significantly associated with the incidence of maternal anemia with OR (95% CI) sequentially 1.38 (1.003-1.92), 0.63 (0.46-0.88) and 1.74 (1.01-3.00). While consumption of iron-added pills during pregnancy was not associated with the incidence of maternal anemia in Indonesia (p = 0.760) and OR (95% CI) = 1.05 (0.76-1.43).
Conclusion: There was no significant relationship between the consumption of poor iron pills during pregnancy with the incidence of maternal anemia in Indonesia. There was a significant relationship between maternal education, maternal residence and bleeding history at birth with the incidence of anemia in the mother.
Considerações sobre a cronologia de algumas mudanças na morfologia verbal do (galego)-português
Authors: Carvalho Maria José 
Published: September 2019

Neste artigo, estudaremos as cronologias das mudanças de alguns fenómenos relacionados com a morfologia verbal (galego)-portuguesa, nomeadamente: (i) Particípios passados de verbos da 2ª conjugação, (ii) O -d- intervocálico no morfema número-pessoal de P5; (iii) Verbos incoativos em -ecer; (iv) Manutenção de -e em formas de Presente do indicativo (com fonema pré-palatal no radical); (v) Mudanças de radical e regularização analógica na flexão de alguns verbos; (vi) Particípios fortes e truncados. O corpus usado consiste numa coleção documental constituída por 153 documentos notariais lavrados entre os séculos XIII e XVI, no mosteiro de Santa Maria de Alcobaça e seus coutos. Não obstante reconhecermos que as cronologias não coincidem simultaneamente para todos os fenómenos, mostrar-se-á que é possível estabelecer diferentes etapas evolutivas, com balizas cronológicas diferenciadas e delimitadas. Esta constatação aponta para a necessidade de se considerar a dimensão diacrónica quando se pretende comparar as línguas ibero-românicas atuais.
Linking leucaena to carbon abatement opportunities in Australia
Authors: King Karen , Burgess Rachel 
Published: September 2019

Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia.The Australian Government has committed to reducing its greenhouse gas (GHG) emissions by 26‒28% below 2005 levels by 2030. The Emissions Reduction Fund (ERF), a center-piece of Australia’s climate change policies, provides incentives to reduce GHG emissions through economy-wide eligible activities, such as energy efficiency, waste management, revegetation, livestock management and savanna fire management. Emissions Reduction Fund methods define eligible activities, how to quantify abatement resulting from the activity and the required compliance measures.The requirements for developing ERF methods that quantify GHG abatement estimates resulting from eligible activities are described. Leucaena planting is used as an example. For an ERF method to be made and maintained, the activity must meet all the legislative requirements. This includes meeting the offsets integrity standards and having regard to any adverse environmental, economic and social impacts.
The Relationships in Novels from the Perspective of Literary Ethics—Taking the Film Lolita as an Example
Authors: Zeng Zhaodong 
Published: August 2019

Vladimir Vladimirovich Nabokov is an outstanding and productive Russian-Amercian writer. As the epitome work of the writer, Lolita must be the most controversial novel without doubt. This novel has been adapted into two versions of films: 1962 version and 1997 version. This paper will analyze the 1997 version of Lolita directed by Adrian Lyne. Most critics have mainly conducted the analysis of the film form the perspective of ethnics, postmodernism, narrative strategy, time as well as the image of death. However, there are few, if any, researches done from the perspective of literary ethics to dig into the relationships in the film. With the integration of ethics methods and literary research methods, literary ethics serves as a major new criticism approach and is mainly employed to conduct the analysis of literature. With the ethical factors unveiled in Lolita, this paper seeks to analyze three relationships: human beings and society, human beings and self, ethics and truth. The paper interprets the film Lolita from the perspective of literary ethics, explores the relationships in the film, exploits Vladimir Vladimirovich Nabokov’ s pursuit of truth, kindness and beauty, and also hopes to provide a new direction for later research on the film Lolita.
Znaczenie poczucia podmiotowości dla aktywności społecznej w przestrzeni samorządowej
Authors: Szostok-Nowacka Patrycja Elżbieta 
Published: August 2019

<p>Artykuł jest prezentacją wyników kwestionariuszowych badań przeprowadzonych w zakresie komunikacji samorządowej, z uwzględnieniem poczucia podmiotowości komunikacyjnej obywateli oraz ich faktycznej aktywności w środowisku lokalnym. Opierając się na autorskiej koncepcji poczucia podmiotowości komunikacyjnej, dokonano jej weryfikacjiw wywiadach kwestionariuszowych przeprowadzonych na 500 respondentach w województwie śląskim w 2016 roku. Celem badania było wykazanie, na ile poczucie podmiotowości, szczególnie tej komunikacyjnej, jest wyznacznikiem faktycznej aktywności obywateli w otoczeniu lokalnym. Główną hipotezę badania stanowiło przekonanie, że poczucie podmiotowości jest związane z aktywnością w przestrzeni samorządowej. W artykule zamieszczono wprowadzenie w tematykę, charakterystykę podmiotowości na poziomie lokalnym, zdefiniowano poczucie podmiotowości ogólnej i komunikacyjnej, zaprezentowano wyniki badań własnych dotyczących znaczenia poczucia podmiotowości komunikacyjnej dla aktywności obywatelskiej oraz sformułowano wnioski. Wyniki potwierdzają, że aktywność komunikacyjna koreluje z faktyczną aktywnością w otoczeniu lokalnym, szczególnie istotne są aspekty podmiotowości komunikacyjnej związane z komunikacją dwustronną. W badaniu wykazano, że poczucie podmiotowości komunikacyjnej nie jest wysokie, co pozwala w pewnym stopniu wnioskować nie tylko o powodach znikomej aktywności obywateli w środowisku lokalnym, ale także stwierdzić, że rozwój samorządowej działalności komunikacyjnej powinien przebiegać w kierunku zachęcania obywateli do aktywnego uczestnictwa w procesach porozumiewania się oraz budowania w nich uzasadnionego przekonania o ważności i przede wszystkim skuteczności tych działań.</p>
COMUNICAÇÃO EM SAÚDE PARA SÍFILIS: LEVANTAMENTO DE AÇÕES DE COMUNICAÇÃO MUNICIPAIS A PARTIR DO OLHAR DOS APOIADORES DO PROJETO RESPOSTA RÁPIDA À SÍFILIS
Authors: Daniel dos Santos Pereira Esdras , Cadaxa Aedê , Paz Josi 
Published: September 2019

rata-se de um levantamento das açõesde comunicação realizadas em municípios prioritários para enfrentamentoà sífilis no Brasil. A amostra compreendeu 72 municípios do âmbito do ProjetoResposta Rápida à Sífilis – ação governamental gerida pelo Ministério da Saúde eexecutada pelo Laboratório de Inovaçãoem Saúde da Universidade Federal do RioGrande do Norte para enfrentamento eredução da sífilis no Brasil. Para realizar olevantamento, foi aplicado questionárioestruturado aos 52 apoiadores territoriaisdo projeto. Foi possível identificar ações decomunicação vinculadas ao enfrentamentoda sífilis nos instrumentos de gestão – PlanoMunicipal de Saúde, Programação Anual,Relatório Anual de Gestão – de 40 municí-pios da amostra, indicando a comunicaçãocomo elemento presente nas políticasde saúde para o enfrentamento da sífilis.
No período de abril a agosto de 2018,foram realizadas produções de materiaisde comunicação voltados ao combate àsífilis em apenas 23 municípios da amostra, o que pode demonstrar que, emboraa comunicação apareça como elementoestruturante do Projeto de RespostaRápida à Sífilis, o desenvolvimento deações e materiais de comunicação ainda éum desafio para o território.
PENGUATAN EKONOMI KREATIF KELUARGA KESENIAN JARANAN DAN BANTENGAN TRAH KANJURUHAN KELURAHAN TLOGOMAS KOTA MALANG
Authors: Andriani Sri , Firdaus Dwi Hidayatul , Suhadak Faridatus 
Published: September 2019

<p><em>Mentoring of society base on economics and business science have formed a group in posdaya, posdaya which became example is posdaya of As-syuro village Tlogomas Malang City. The society that developed art actually come from the Assembly of worshipers tahlil and tiba'an</em><em>.</em><em> They have been able to operate profesionally their tools, or in other words just do activities as a hobby and do friendship (Silaturahim) between pilgrims (jama’ah).</em><em> So the common condition need the change of managerial ability.</em><em> There is no handling expected can increase family income, and ultimately become superior product in Tlogomas and also can create a creative economy that also became the goal of the current Administration (President of Joko widodo).</em><em> So. All condition commonly need change of managerial ability.</em><em></em></p><p> </p><p>Pendampingan masyarakat berbasis ilmu ekonomi dan bisnis yang telah membentuk kelompok dalam pos daya, maka pos daya yang yang menjadi dampingan adalah pos daya As-Syuro Kelurahan Tlogomas Kota Malang.<strong> </strong>Masyarakat yang mengembangkan kesenian ini sebenarnya bermula dari perkumpulan jamaah tahlil dan tiba’an. Mereka sudah mampu mengoperasikan secara profesioanal alat-alat pertunjukannya, atau dengan kata lain hanya melakukan kegiatan sebatas hobi dan melakukan silaturahim antar jamaah<strong>. </strong>Belum ada penanganan yang diharapkan memperoleh pendapatan yang dapat menambah pendapatan keluarga, dan pada akhirnya menjadi produk ungulan Kelurahan Tlogomas sekaligus dapat menciptakan ekonomi kreatif yang juga menjadi tujuan pemerintah sekarang (Presiden Joko widodo). Maka kondisi yang ada secara umum memerlukan pembenahan kemampuan manajerial.</p>
ANALISIS JAWABAN MAHASISWA DALAM MENYELESAIKAN SOAL MATERI BILANGAN BERPANGKAT PADA MATAKULIAH ASESMEN PEMBELAJARAN MATEMATIKA
Authors: Sunardi Sunardi 
Published: August 2019

Masalah dalam penelitian ini bagaimana kemampuan mahasiswa dalam menyelesaikam soal materi bilangan berpangkat. Penelitian ini betujuan: untuk mengetahui kemampuan mahasiswa dalam menyelesaikan soal materi bilangan berpangkat yang mengikuti mata kuliah assesmen terutama pada tugas merakit soal. Populasi dalam penelitian ini adalah seluruh mahasiswa yang mengikuti mata kuliah asesmen sebanyak 46 mahasiswa. Pengumpulan data dilakukan melalui tes 6 soal esai yang dibedakan menjadi 3 kategori. Setelah dilakukan penelitian, diperoleh 69,5% mahasiswa yang mampu menjawab dengan benar soal pemahaman konsep (K-I) dengan nomor 1 dan 2 atau dapat di kategorikan baik dalam memahami konsep pada materi bilangan berpangkat, tetapi masih terdapat mahasiswa belum mampu menggunakan dan memanfaatkan serta memilih prosedur atau operasi tertentu pada situasi yang tepat dalam menyelesaikan soal materi bilangan berpangkat.Kemampuan penalaran (K-II) dengan nomor soal 3 dan 4 didapatkan persentase 57,5% yang dikategorikan cukup dalam menggunakan penalaran pada materi bilangan berpangkat, penyebabnya adalah mahasiswa masih salah dalam mengajukan dugaan sehingga mahasiswa pun salah dalam melakukan manipulasi matematika dan Kemampuan memecahkan masalah (K-III) dengan nomor soal 5 dan 6 didapat persentase 56,5% yang dikategorikan cukup dalam memecahkan masalah pada materi bilangan berpangkat Saran bagi mahasiswa agar lebih bersungguh-sungguh dalam mempelajari konsep pada materi bilangan berpangkat dan diharapkan mahasiswa sering berlatih sendiri dalam menyelesaikan masalah/soal yang lebih bervariatif, seperti bentuk soal penalaran dan pemecahan masalah agar penguasaan bilangan berpangkat lebih maksimal
DEGRADASI KOMPONEN SELULOSA, HEMISELULOSA, DAN PATI TEPUNG KULIT UBI KAYU MENJADI GULA REDUKSI OLEH Aspergillus niger, Trichoderma viride, DAN Acremonium sp. IMI 383068
Authors: Jayus Jay , Nafi' Ahmad , Hanifa Anis Shabrina 
Published: September 2019

As the solid waste produced from cassava processing industry such as tapioca factory or its derivatives, the cassava peel is potential to be use as a source of reducing sugar through hydrolysis process, since the peels contains a high amount of starch and lignocellulose components. The more environmentally friendly enzymatic hydrolysis using several microorganisms will be introduced in this study as an alternative to avoid the unsafe acid hydrolysis. However, the hydrolysis process using a single microorganism is not efficient since the hydrolytic enzyme produced is limited to a single enzyme, while the component in the cassava peels to be hydrolyzed is diverse which include cellulose, lignin, hemicellulose and starch. Therefore, it is necessary to optimize the hydrolysis process by combining several microorganisms (A. niger, T. viride and Acremonium sp. IMI 383068) which produced different specificity of hydrolytic enzyme depending on the substrate available in the cassava peels. The aims of this research were to determine the effect of single and mixed culture on the amount of reducing sugar released during the simultaneous cultivation. The result showed that the use of simultaneous mixed cultures during hydrolysis process was able to produce higher reducing sugar compare to that of single culture. The hydrolysis of cassava flour using a single strain of A. niger, T. viride and Acremonium sp. IMI 383068 respectively produced 4.86 g/L, 4.02 g/L, and 1.68 g/L of reducing sugar, while the hydrolysis of it using simultaneous mixed cultures of A. niger, T. viride, and Acremonium sp. IMI 383068 produced 7.23 g/L of reducing sugar.
Keywords: cassava peels, hydrolysis, reducing sugar
DESINFECÇÃO DE EFLUENTE FINAL DE ABATEDOURO DE BOVINOS COM ÁCIDO PERACÉTICO PARA FINS DE REÚSO
Authors: Cavallini Grasiele Soares , Silva Wesley Pereira , Gonzaga Mayara Ferreira 
Published: August 2019

A bovinocultura é uma das principais atividades produtivas do agronegócio brasileiro, colocando o país no primeiro lugar em exportações de carne bovina do mundo. O grande número de abate de animais implica na geração de elevado volume de efluente líquido, sendo estimado um consumo de 2500 litros de água por animal abatido. Este efluente, além de rico em matéria orgânica, também apresenta microrganismos patogênicos provenientes da lavagem das vísceras e das fezes dos animais. A inativação destes microrganismos não ocorre por tratamento secundário, como lagoas de estabilização, a forma de tratamento mais empregada para este tipo de efluente, restringindo as possibilidades de reúso deste efluente. Assim, este trabalho investigou um desinfetante não clorado, o ácido peracético (APA) 15%, o qual possibilitou, além da desinfecção, a oxigenação do efluente. O tratamento terciário proposto teve o objetivo de melhorar a qualidade do efluente final para o seu possível reúso. A concentração de 5mg/L de APA em um tempo de contato de 10 minutos foram suficientes para a adequação microbiológica exigida pelo Manual de reúso da EPA, para reúso agrícola restritivo. No entanto, a dosagem de 20mg/L de APA, além de maior desinfecção, não proporciona aumento de DBO do efluente.
Palavras-chave: Reúso de efluente, irrigação de pastagem, ácido peracético.
Menggapai Ketenangan Hati dengan Dzikrullah
Authors: Istianah Istianah 
Published: August 2019

<p class="07KatakunciKeywords">This was article described importing dzikrullah to peacefulness. While our was experienced worries, panic’s, depresstion’s, anxieties, and others, it was effected mental disorders, so Al-Qur’an had therapy called dzikrullah (QS. Ar-Ra’du [13]: 28). This was dzikrullah instructed in (QS. Al-Baqarah [2]: 152) and (QS. Al-A’raf [7 ]: 205). Dzikir was form vebal speech, gesture, or heart throb appropriated religious manners in closer to Allah. Those aim dzikir was closered to Allah for mental resignational achievement, totality commit to Allah. Basically level’s in dzikir was read <em>la ilaha illa Allah</em>. Dzikir was controlled for “ washed soul” by Imam Ghazali called <em>tazkiyah al-nafs</em> in bad caracters, there were hasad, envy, revenge, arrogancies, ujub, riya, stingy and others. Those caracters was domited thought and peoples behaviour, so it would put deviations activities. Dzikir said Ibnu Atha’illah called active flame, if was meet firewood that it could flames. If was house darkness that could torch. And also house could light, it colud highest light.</p>
Islam dan Pengobatan Abad 21: Balur Gria Muria Kudus Pengobatan Kolaborasi Ilmuwan dan Tabib
Authors: Aslamah Sayyidah 
Published: August 2019

<p class="06IsiAbstrak">Developing of Sciences in 21 Centuries is good knowlagement. This paper talks South East Studies and Religion Studies integrating. With concerned Human Art Studies are discussing how is Indonesian Muslim scholar done for integration knowlage between medition on Tradisional studies and modern medition studies. In addition paper will be discussing tropoical culture integrated on Science. It is said that integrated knowlage of indonasion scholar on collaborating western knowlage to eastern knowlage for medition integrated that is called by balur that are boreh and lulur. Balur is getting massage body with tradisinal medicion consisting on Coffe and Tobaco. Balur is method for healing cencer. Balur will be explaning on how tobacco and coffe are working on biology data with Topical botany, physic data with kuantum on magnetic field, and kimia data with free radical polusion. With the funtions of three knwolages are integrated on working proses that will to be madision for canser. Lembaga Penelitian dan Peluruhan Radikal Bebas (LP2RB) under Center Rumah Sehat Malang dan Lembaga Penelitian dan Pengembangan Peluruhan Radikal Bebas in Gria Balur Muria Kudus are laboratory and hospital for cencer tredment. This paper will be taking bout two Center but focuses on LPRB under Gria Muria Kudus. The Conluding of paper will show the Uniqe Partn of nusantara tradition with local wisdom knowlage on natural Science.</p>