bluuebunny/crossref_metadata_2025_split huggingface dataset:
INSILICO MODELLING ON SOME C14-UREA TETRANDRINE COMPOUNDS AS POTENT ANTI-CANCER AGAINST HUMAN ERYTHROLEUKEMIA (HEL) CELL LINE
Authors: Abdullahi Mustapha , Shallangwa Gideon A. , Ali Tijjani , Uzairu Adamu 
Published: March 2019

Insulin modeling was performed on 28 C14-urea tetrandrine compounds as inhibitors of leukemic (HEL) cell lines using Quantitative Structure-Activity Relationship (QSAR) method. The structure of the inhibitors was correctly drawn, then geometrically optimized at Density Functional Theory (DFT) level (DFT / B3LYP / 6-31G *) with Spartan 14 V1.1.4. Also, molecular descriptors of the inhibitors were calculated with PaDEL calculator, and the results were partitioned into training and test set after data pretreatment. The training set was used to generate a model by employing genetic function approximation in choosing best descriptors to form the model. The validation parameters of the model include; R ^ 2 (train) at 0.8067, LOF 0.037 r ^ 2 (QCV) to 0.6378 R ^ 2 (test) 0.7629 of the CRP ^ 2 and the 0. 6990 Which have passed the acceptance criteria for a QSAR model worldwide. In addition, the model depicted four (4) descriptors, AATS4v, AATS5i, AATSC5i, and GATS5m with positive meanings signifying that increase in these descriptors will positively influence and increase the activity of the inhibitors. This study depicts a route in designing and synthesizing new C14-urea tetrandrine compounds with better inhibitory potentials.
THEORETICAL MODELLING FOR INVESTIGATING SOME ACTIVE COMPOUNDS AS POTENT INHIBITORS AGAINST LUNG CANCER: A MULTI-LINEAR REGRESSION APPROACH
Authors: Adeniji Shola Elijah , Ovaku Momohjimoh Idris , Saidu Tukur , Ugochukwu Ahanonu Saviour , Shallangwa Gideon , Uzairu Adamu 
Published: March 2019

A Quantitative Structure Activity Relationship (QSAR) study has been attempted on ciprofloxacin derivatives as potent anti-lung cancer. QSAR models were derived with the aid of multi-linear regression (MLR) approach using topological, molecular shape, electronic and structural descriptors. The predictive ability of the QSAR models generated were validated and the best model selected has squared correlation coefficient (R2) of 0.954801, adjusted squared correlation coefficient (Radj) of 0.939265, Leave one out (LOO) cross validation coefficient () value of 0.907523. The external validation set used for confirming the predictive power of the model has its R2pred of 0.8387. The QSAR models point out that AATSC2m, VR3_Dzp and BIC2 are the important descriptors effectively describing the bioactivity of these compounds.
ANÁLISE ESPACIAL DA VIOLÊNCIA AUTOPROVOCADA EM ADOLESCENTES: SUBSÍDIO PARA ENFRENTAMENTO
Authors: De Abreu Paula Daniella , Da Silva Lúcio Firley Poliana , De Araújo Ednaldo Cavalcante , Ribeiro de Vasconcelos Eliane Maria , Da Cunha Tarcisio Neves , Dos Santos Claudia Benedita 
Published: March 2019

RESUMOObjetivo: analisar a correlação entre as taxas brutas de violência autoprovocada em adolescentes e ano de ocorrência e o padrão espacial da ocorrência dos casos notificados de violência autoprovocada em adolescentes. Método: estudo ecológico com tendência temporal, desenvolvido a partir de dados notificados no período de 2009 a 2014 referentes aos casos de violência autoprovocada em adolescentes residentes no Estado de Pernambuco, coletados por município pelo Sistema de Informação de Agravos de Notificação. Os dados foram analisados com o auxílio do programa TerraView, versão 4.2.2, a partir das bases cartográficas municipais de Pernambuco e quantitativo populacional fornecidos pelo Instituto Brasileiro de Geografia e Estatística. Resultados: obteve-se correlação linear estatística positiva entre as variáveis representadas pelas taxas brutas e ano de ocorrência, além da inexistência de associação espacial significante. Conclusões: a aplicação de abordagens integradas que considerem a situação do entorno, configura-se em importante estratégia para construção de ações em saúde. Descritores: Análise Espacial; Promoção da Saúde; Violência; Comportamento do Adolescente; Enfrentamento.
Attitude and Self-Efficacy of Students with Motor Impairments Regarding Touch Input Technology
Authors: Schipor Maria-Doina 
Published: March 2019

We address in this work the role touch interfaces could play in reducing the inequalities motor disabled students confront with. To this end, we conduct a between subjects experiment, involving students with motor disability and able bodied participants, investigating both the attitude and the self-efficacy with respect to the utilisation of touch technology in the everyday life. We rely on the well-established relationship between attitude, self-efficacy, and actual performance in order to explore strategies for increasing the actual performances through psychological means. The statistical analysis indicates significant differences between subjects with motor impairments and able bodied participants in the case of both attitude and self-efficacy. We connect these outcomes with strategies for reducing the inequalities for the students with motor disabilities in the context of educational activities.
UM PROCESSO DE JORNALISMO á€ ÉPOCA DA INDEPENDáŠNCIA: Maranhão, 1829-1832
Authors: ARAÚJO RONI CÉSAR ANDRADE DE 
Published: March 2019

Analisa a documentação que compôs o processo judicial movido pelo Deputado Odorico Mendes contra o Ex-presidente do Maranhão Costa Pinto, na Corte do Rio de Janeiro, em 1829. Todo o corpo documental do processo está disponá­vel num livreto que compõe o acervo do Arquivo Nacional do Rio de Janeiro. Com exceção a um ou outro documento, de modo geral, esse processo ainda não foi discutido no á¢mbito das produções acadêmicas.Palavras-chave: Imprensa. Independência. Império do Brasil. Maranhão. A PROCESS OF JOURNALISM AT THE TIME OF INDEPENDENCE: Maranhão, 1829-1832Abstract: It analyzes the documentation that composed the lawsuit filed by the Deputy Odorico Mendes against the former President of Maranhao Costa Pinto, at the Court of Rio de Janeiro, in 1829. All the documental body is disposable on a booklet that composes the National Archive of Rio de Janeiro”™s collection. With the exception of one or another document, in a general way, this process has not yet been discussed on the scope of the academic productions.Keywords: Press. Independence. Empire of Brazil. Maranhão. UN PROCESO DE PERIODISMO EN LA ÉPOCA DE LA INDEPENDENCIA: Maranhão, 1829-1832Resumen: Analiza la documentación que compuso el proceso judicial movido por el diputado Odorico Mendes en contra del expresidente del Maranhão Costa Pinto, en la Corte de Rá­o de Janeiro, en 1829. Toda documentación del proceso está disponible en un folleto que compone el acervo del Archivo Nacional de Rio de Janeiro. Con excepción de uno u otro documento, de modo general, ese proceso aún no ha sido discutido en el ámbito de las producciones académicas.Palabras clave: Prensa. Independencia. Imperio de Brasil. Maranhão.
The design process: A global vision versus a fragmentary vision
Authors: Zahaf Alia Kallel 
Published: March 2019

This paper presents a new approach in the way of thinking design process with a dialectical vision: grammar of production/grammar of reception. An approach, oscillating between the fragmentary vision and the global vision and evolves along with the currents and the structure of human thinking. The fragmentation is considered as indispensable to the setting in frame, to the representation and consequently to the configuration of the conceived object. It is also necessary to the perception, the apprehension, the assimilation and consequently the appropriation of the perceived object. On the other hand, the globalization, and this since the antiquity, has always been considered as a vision that has allowed man to master his field of intervention. In design, whether in practice or in theory, the objective of a global vision is to establish a certain systemic coherence in every production. Hence, we find ourselves face a questioning that will expose Design to a dialogic oscillating vision between the global and the fragmentary.

Keywords:design process, user experience, complexity, global approach, fragmentary approach.
Comparison of design and application criteria for various methods used in reinforced concrete beam strengthening
Authors: Seckinli Muhammed , Arslan Musa Hakan 
Published: March 2019

The design of the buildings to the earthquakes is a very critical issue. Some of existing reinforced concrete buildings does not have sufficient performance in terms of earthquake. These buildings must be demolished or strengthened. Strengthening design is not a simple engineering account but requires deep knowledge of composite material behavior. In this study, the structural advantages and disadvantages of various strengthening types of reinforced concrete beams are investigated. In this scope, reinforced concrete jacketing, strengthening with steel plate, strengthening methods with fiber polymers and external steel tie are investigated in detail. In the numerical part of the study, the effects of these methods are highlighted. In the analyzes, the reinforced concrete jacketing increased the bending and shear strength of the existing beam but the difficulty of this application was found to make it difficult for such designers to be preferred in beams. Also, the addition of new reinforced concrete section to be added to the lower zone of the beam has also contributed to the bending capacity by increasing the useful height of the beam. However, the strengthening with steel plate has a significant advantage in terms of bending capacity or shear and bending capacity and strengthening with fibrous polymer has significant benefit in shear capacity. It is also seen that carbon fiber polymer plates increase the bending strength as steel plates due to high tensile strength. The external wrapping is only useful in shear capacity of beam.
Nombramiento de árbitros en supuestos de sede indeterminada (a propósito del Auto del TSJ de Madrid de 8 mayo de 2018) = Appointment of arbitrators in cases of indeterminate seat (decision of the High Court of Justice of Madrid of 8 May 2018)
Authors: Gómez Jene Miguel 
Published: March 2019

Resumen: Comentario al auto dictado por el TSJ de Madrid en virtud del cual declara su compe­tencia judicial territorial para nombrar árbitro en un supuesto en el que la sede del arbitraje no estaba determinada y ninguna de las partes tenía residencia en España.Palabras clave: arbitraje internacional, nombramiento de árbitro, sede indeterminada del arbitra­je, residencia de las partes en el extranjero, Foro de necesidad.Abstract: Commentary on the resolution of the High Court of Madrid declaring its territorial ju­risdiction to appoint an arbitrator in a case in which the seat of the arbitration was not determined and neither the parties had its residence in Spain.Keywords: international arbitration, appointment of the arbitrator, indeterminate seat of the arbi­tration, residence of the parties abroad, Forum necessitatis.
Reconocimiento y ejecución parcial de resoluciones judiciales extranjeras y orden público en la Ley de Cooperación Jurídica Internacional en materia civil. Comentario al auto de la Audiencia Provincial de Gipuzkoa (Seccion 2ª) núm. 120/2018, de 9 de marzo = Partial recognition and enforcement of foreign decisions and public order under the Spanish Act on International Judicial Cooperation in civil matters. Comment on the act of the Spanish Court of Appeal of Gipuzkoa (Section 2) number 120/2018, Of 9th march
Authors: Magallón Elósegui Nerea 
Published: March 2019

Resumen: En el presente Auto la Audiencia Provincial de Gipuzkoa otorga el exequatur a una Sentencia de divorcio dictada por el Tribunal Jaafarita Religioso de Saida del Líbano con la excepción de determinados convenios considerados contrarios al orden público.Palabras clave: Exequatur, ley de cooperación jurídica internacional, divorcio, orden público, reconocimiento parcial.Abstract: This paper analyzes the Act of the Spanish Court of Appel of Gipuzkoa about the recognition and enforcement of the Judgment of Court Jaafarita of Saida (Libano) about a marriage dissolution.Keywords: Exequatur, partial enforcement, Spanish Act on International judicial cooperation, marriage dissolution, public order.
Irrational-Behavior-Proof Conditions Based on Limit Characteristic Functions
Authors: Liu Cui , Gao Hongwei , Petrosian Ovanes , Xue Juan , Wang Lei 
Published: March 2019

Abstract
Irrational-behavior-proof (IBP) conditions are important aspects to keep stable cooperation in dynamic cooperative games. In this paper, we focus on the establishment of IBP conditions. Firstly, the relations of three kinds of IBP conditions are described. An example is given to show that they may not hold, which could lead to the fail of cooperation. Then, based on a kind of limit characteristic function, all these conditions are proved to be true along the cooperative trajectory in a transformed cooperative game. It is surprising that these facts depend only upon the individual rationalities of players for the Shapley value and the group rationalities of players for the core. Finally, an illustrative example is given.
Noether’s Symmetries and Its Inverse for Fractional Logarithmic Lagrangian Systems
Authors: Jiang Jun , Feng Yuqiang , Xu Shuli 
Published: March 2019

Abstract
In this paper, Noether’s theorem and its inverse theorem are proved for the fractional variational problems based on logarithmic Lagrangian systems. The Hamilton principle of the systems is derived. And the definitions and the criterions of Noether’s symmetry and Noether’s quasi-symmetry of the systems based on logarithmic Lagrangians are given. The intrinsic relation between Noether’s symmetry and the conserved quantity is established. At last an example is given to illustrate the application of the results.
Produced Flowback Salts vs. Induced-Fracture Interface: A Field and Laboratory Study
Authors: Zolfaghari Ashkan , Dehghanpour Hassan , Bearinger Doug 
Published: March 2019

Summary
The water recovered from hydraulic-fracturing operations (i.e., flowback water) is highly saline, and can be analyzed for reservoir characterization. Past studies measured ion-concentration data during imbibition experiments to explain the production of saline flowback water. However, the reported laboratory data of ion concentration are approximately three orders of magnitude lower than those reported in the field. It has been hypothesized that the significant surface area created by hydraulic-fracturing operations is one of the primary reasons for the highly saline flowback water.
In this study, we investigate shale/water interactions by measuring the mass of total ion produced (TIP) during water-imbibition experiments. We conduct two sets of imbibition experiments at low-temperature/low-pressure (LT/LP) and high-temperature and high-pressure (HT/HP) conditions. We study the effects of rock surface area (As), temperature, and pressure on TIP during imbibition experiments. Laboratory results indicate that pressure does not have a significant effect on TIP, whereas increasing As and temperature both increase TIP. We use the flowback-chemical data and the laboratory data of ion concentration to estimate the fracture surface area (Af) for two wells completed in the Horn River Basin (HRB), Canada. For both wells, the estimated Af values from LT/LP and HT/HP test results have similar orders of magnitude (approximately 5.0×106 m2) compared with those calculated from production and flowback rate-transient analysis (RTA) (approximately 106 m2). The proposed scaleup procedure can be used as an alternative approach for a quick estimation of Af using early-flowback chemical data.
A Novel Deployment of Chelant and Mud Acid in a Deepwater Frac Packed Well to Remediate Severe Formation Damage
Authors: Pettitt-Schieber Lucy , Garzon Francisco O. , Aman Michael , Gramin Pavel , Ramnath Lawrence 
Published: March 2019

Abstract
In the Gulf of Mexico the wells are usually completed as cased and perforated or frac packed. These wells can be damaged during the drilling phase, completion phase and/or when they are on production. This paper presents the unique combined use of chelant and mud acid treatments to remediate a deepwater Gulf of Mexico well with severe formation damage. Fluid qualification work optimized the treatment, which was deployed using both coiled tubing and bullheading methods. Surveillance, surface read out and memory, were utilized throughout the intervention to understand the effectiveness of each treatment, along with final fluid analysis.
Both coiled tubing and bullheading were used for specific purposes. Given the completion design configuration, a mud acid screen wash was deployed using coiled tubing to clean the screens and improve near-wellbore access. Care was taken to avoid reacting low pH mud acid with high pH chelant. This reaction would reduce the benefits of each treatment, in addition to risking precipitation of by-products in the reservoir. Therefore, the operation was sequenced such that additional flowbacks allowed for reservoir clean-up prior to the next fluid deployment. Lab testing showed multiple soaking and refreshes of the slow-reacting chelant was optimal. A final mud acid bullhead treatment was deployed to matrix stimulate and treat the reservoir 3 - 5 feet into the near-wellbore region. During the operation, several forms of surveillance were planned to understand the effectiveness of each chemical treatment. This included temperature surveys, surface flowback samples analysis to understand the effectiveness of the treatments, and spinner information to quantify zonal contribution.
Post-production results showed an improvement in overall well productivity due to a reduction in formation damage. These results are supported by in-well surveillance and post-intervention fluid analysis. The most basic of all measurements, temperature, proved to be the most effective in understanding damage removal evolution and reservoir contribution throughout the intervention.
This paper will present the novel combined application of mud acid and chelant stimulation treatments to remediate a frac packed well with combined severe initial well construction damage and post-production formation damage.
RLWI Deployed Electric Line Stroker Application for Safe and Secure Crown Plug Retrieval and Setting in High-Current Deep-Water Operations
Authors: Murchie Stuart , Jørgensen Erland , Egeland Alexander , Saetrevik Martin , Boge Erik , Hals Knut , Sbordone Andrea 
Published: March 2019

Abstract
A/S Norske Shell needed to carry out tubing hanger crown plug (THCP) removal from a riserless light well intervention (RLWI) vessel in the Norwegian sector of the North Sea. There were concerns that the conventional application of mechanical jarring with slickline tools could not be used due to the combination of deep water and high sea currents in the specific field. A safer, more controlled and assured method was needed to withstand this extreme environment and provide the certainty of task success.
Theoretical studies and practical testing were conducted at the supplier's test site to verify the impact sea current had on cables and toolstring assemblies. Different scenarios were analysed and the most effective and lowest cost solution was determined. An electric line deployed and powered electrohydraulic stroker device was selected, which did not require any cable actuation to generate the pull forces required to unseat the crown plug.
Toolstring space-out was critical to ensure the stroker anchor was above and clear of the well control package (WCP) and positioned to prevent any inadvertent damage to the lubricator. In addition, a release tool and a shearable stem provided back-up safety capability for well control. A modification to an existing stroker was designed and a prototype built and tested at the onshore facility.
The final stroker toolstring design was tested out successfully on a more benign shallow subsea well, where the highly accurate force and movement control of the stroker, coupled with real-time surface readout, enabled a safe and secure crown plug pulling and installation operation. The targeted operation in a deep-water, high-sea current environment was then carried out successfully, applying many lessons learned and process improvements from the trial well.
In conclusion, the use of electrohydraulic stroker technology was proved to be a viable alternative for crown plug retrieval and setting operations, whilst bringing heightened visibility and control to such an operation.
SCSSV Flapper Milling Using E Line Solution
Authors: Heriyanto Syahrul , Pracoyo Damar , Sutama Surya Putra 
Published: March 2019

Abstract
This paper discusses the success of an operation involving E-line unit to mill Surface Controlled Subsurface Safety Valve (SCSSV) flapper on a well, which has been detached from its hinge. The flapper has become obstruction to well intervention activity on this well, preventing a zone shifting job which potentially would triple the well's oil production.
The SCSSV flapper becoming a restriction was identified from slickline tubing clearance job, but the fact that it has been detached from its hinge was learned after getting the result from running downhole camera. The objective of the operation is regaining access to the zone below SCSSV for zonal isolation and perforation. The bit was specially designed to mill the flapper while minimizing the flapper rotational action that might have caused by the milling, hence increasing the milling effectiveness. As this is the first loose SCSSV flapper milling for Medco E&P Natuna, a System Integrity Test (SIT) was conducted at Service Company facility with actual flapper of the same type to prove the method would work, prior to the actual job onsite.
E-line milling with special designed bit was proven to be the effective method to solve the restriction issue in this well. The restriction was able to be milled, and rotational movement of the flapper which could have impeded the milling operation was minimized. A full-bore access was made available upon the milling job completion, which allow for future intervention work.