bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culturally Responsive Indigenous Evaluation and Tribal Governments: Understanding the Relationship
Authors:   Waapalaneexkweew (Nicole Bowman, Mohican/Lunaape), Dodge‐Francis Carolee 
Published: July 2018

AbstractOver the last decade, culturally responsive (CR) indigenous evaluation resources have become more readily available to academia and evaluation practitioners within the mainstream literature. This is a direct result of the growing number of Indigenous evaluators in the field; the increased access and opportunities for Indigenous and non‐Indigenous partners collaborating on evaluation projects and academic initiatives; and changes in policy, programming, and funding that better support CR and/or culturally responsive indigenous evaluation (CRIE) initiatives. This chapter examines four overarching content summary areas for CRIE: historical and legal foundations; design approaches; application; and practical CRIE strategies for strengthening professional practice and building evaluation industry capacities for CRIE.
Efficient Vapor‐Phase Selective Hydrogenolysis of Bio‐Levulinic Acid to γ‐Valerolactone Using Cu Supported on Hydrotalcite Catalysts
Authors: Mitta Harisekhar , Seelam Prem Kumar , Chary K. V. Raghava , Mutyala Suresh , Boddula Rajender , Inamuddin  , Asiri Abdullah M. 
Published: July 2018

AbstractIn this work, Cu nanoparticles (Cu NPs, 2‐20 nm) supported on Hydrotalcite catalysts exhibit enhanced selectivity for γ‐valerolactone (GVL) during hydrogenolysis of levulinic acid (LA). At 260 °C, over 3 wt% Cu achieved 87.5% of LA conversion with a maximum GVL selectivity (95%). In contrast, LA hydrogenolysis over 3Cu/Hydrotalcite catalyst is highly active and stable toward the production of GVL due to balanced acido‐basicity and higher Cu dispersion with ultrasmall particle sizes, which are investigated through the temperature programmed desorption (TPD) of ammonia, N2O titration, and transmission electron microscopy (TEM) analysis. Hydrotalcite in combination with inexpensive Cu catalyst is found to be an efficient and environmentally benign for LA hydrogenolysis.
Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone Influence Muscle Outcomes in Children and Adolescents
Authors: Wright Christian S , Laing Emma M , Pollock Norman K , Hausman Dorothy B , Weaver Connie M , Martin Berdine R , McCabe George P , Peacock Munro , Warden Stuart J , Hill Gallant Kathleen M , Lewis Richard D 
Published: July 2018

ABSTRACT

Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled vitamin D intervention in US children and adolescents, we examined the associations between changes in vitamin D metabolites and changes in muscle mass, strength, and composition after 12 weeks of vitamin D3 supplementation. Healthy male and female, black and white children and adolescents between the ages of 9 and 13 years from two US states (Georgia 34°N and Indiana 40°N) were enrolled in the study and randomly assigned to receive an oral vitamin D3 dose of 0, 400, 1000, 2000, or 4000 IU/d for 12 weeks between the winter months of 2009 to 2011 (N = 324). Analyses of covariance, partial correlations, and regression analyses of baseline and 12-week changes (post-baseline) in vitamin D metabolites (serum 25(OH)D, 1,25(OH)2D, intact parathyroid hormone [iPTH]), and outcomes of muscle mass, strength, and composition (total body fat-free soft tissue [FFST], handgrip strength, forearm and calf muscle cross-sectional area [MCSA], muscle density, and intermuscular adipose tissue [IMAT]) were assessed. Serum 25(OH)D and 1,25(OH)2D, but not iPTH, increased over time, as did fat mass, FFST, forearm and calf MCSA, forearm IMAT, and handgrip strength (p &lt; 0.05). Vitamin D metabolites were not associated with muscle strength at baseline nor after the 12-week intervention. Changes in serum 25(OH)D correlated with decreases in forearm IMAT, whereas changes in serum iPTH predicted increases in forearm and calf MCSA and IMAT (p &lt; 0.05). Overall, increases in 25(OH)D did not influence muscle mass or strength in vitamin D-sufficient children and adolescents; however, the role of iPTH on muscle composition in this population is unknown and warrants further investigation. © 2018 American Society for Bone and Mineral Research.
Extraction of rotenoids from Derris elliptica using supercritical CO2
Authors: Baldino Lucia , Scognamiglio Mariarosa , Reverchon Ernesto 
Published: July 2018

AbstractBACKGROUNDSupercritical (SC)‐CO2 extraction of rotenoids from Derris elliptica roots was proposed using fractional separation of the extracts and operating at increasing pressure.RESULTSThe best processing conditions were found at 200 bar, 40 °C and 1.2 kg h−1 SC‐CO2 flow rate, obtaining a final product with a concentration of 93% w/w of rotenone and rotenoids, and a yield of active principles of 6.70% w/w with respect to the vegetable matrix. Very small quantities of waxes were found, up to 0.05% w/w; this result can be explained considering the reduced surface‐to‐volume ratio of this vegetable material.CONCLUSIONExtraction kinetics data confirmed that, in this case, the extraction process was controlled by solubility limitation of the active compounds in the supercritical solvent. © 2018 Society of Chemical Industry
Glycerol valorization to lactic acid catalyzed by hydroxyapatite‐supported palladium particles
Authors: Shen Lingqin , Yu Zhongyong , Zhang Di , Yin Hengbo , Wang Chengtao , Wang Aili 
Published: July 2018

AbstractBACKGROUNDCatalytic formation of lactic acid from biomass glycerol is a sustainable alternative to the conventional fermentation process starting from carbohydrate and the chemical route using HCN and acetaldehyde. Highly concentrated glycerol can be effectively converted to lactic acid using hydroxyapatite‐supported palladium particles in the presence of NaOH.RESULTSThe 3% hydroxyapatite‐supported palladium catalyst (Pd3/HAP) demonstrates excellent activity (TOF = 1274 h−1 for a batch time of 90 min) with a high selectivity (95%) towards lactic acid at 99% glycerol conversion (230 °C, NaOH:glycerol molar ratio = 1.1, and glycerol/total Pd intake = 1926). Under the same reaction conditions, the selectivities of lactic acid were 82% and 90% on Pd0.75/HAP and Pd1.5/HAP catalysts, respectively. The Pd3/HAP catalyst was recycled five times in a batch set‐up without a significant drop in activity and lactic acid selectivity, which is indicative of good catalyst stability.CONCLUSIONSPd‐based catalysts on available hydroxyapatite supports are efficient catalysts for glycerol selective oxidation. The catalysts possess active PdO and Pd0 species well dispersed on the functionalized hydroxyapatite support. Pd0 nanoparticles and NaOH synergistically catalyze the reaction process. © 2018 Society of Chemical Industry
Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest
Authors: Harrison Mark C. , Arning Nicolas , Kremer Lukas P. M. , Ylla Guillem , Belles Xavier , Bornberg‐Bauer Erich , Huylmans Ann Kathrin , Jongepier Evelien , Piulachs Maria‐Dolors , Richards Stephen , Schal Coby 
Published: July 2018

AbstractThe German cockroach,Blattella germanica, is a worldwide pest that infests buildings, including homes, restaurants, and hospitals, often living in unsanitary conditions. As a disease vector and producer of allergens, this species has major health and economic impacts on humans. Factors contributing to the success of the German cockroach include its resistance to a broad range of insecticides, immunity to many pathogens, and its ability, as an extreme generalist omnivore, to survive on most food sources. The recently published genome shows thatB. germanicahas an exceptionally high number of protein coding genes. In this study, we investigate the functions of the 93 significantly expanded gene families with the aim to better understand the success ofB. germanicaas a major pest despite such inhospitable conditions. We find major expansions in gene families with functions related to the detoxification of insecticides and allelochemicals, defense against pathogens, digestion, sensory perception, and gene regulation. These expansions might have allowedB. germanicato develop multiple resistance mechanisms to insecticides and pathogens, and enabled a broad, flexible diet, thus explaining its success in unsanitary conditions and under recurrent chemical control. The findings and resources presented here provide insights for better understanding molecular mechanisms that will facilitate more effective cockroach control.
Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs
Authors: Gadina Massimo , Johnson Catrina , Schwartz Daniella , Bonelli Michael , Hasni Sarfaraz , Kanno Yuka , Changelian Paul , Laurence Arian , O’Shea John J 
Published: July 2018

Abstract
In this era, it is axiomatic that cytokines have critical roles in cellular development and differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines is known to contribute to diverse inflammatory and immune-mediated disorders. In fact, the past 20 years have witnessed the rapid translation of basic discoveries in cytokine biology to multiple successful biological agents (mAbs and recombinant fusion proteins) that target cytokines. These targeted therapies have not only fundamentally changed the face of multiple immune-mediated diseases but have also unequivocally established the role of specific cytokines in human disease; cytokine biologists have many times over provided remarkable basic advances with direct clinical benefit. Numerous cytokines rely on the JAK-STAT pathway for signaling, and new, safe, and effective small molecule inhibitors have been developed for a range of disorders. In this review, we will briefly summarize basic discoveries in cytokine signaling and briefly comment on some major unresolved issues. We will review clinical data pertaining to the first generation of JAK inhibitors and their clinical indications, discuss additional opportunities for targeting this pathway, and lay out some of the challenges that lie ahead.
Review on first generation of JAK inhibitors, including opportunities for targeting this pathway and some of the challenges that lie ahead.
Introducing changes at work: How voice behavior relates to management innovation
Authors: Guzman Felipe A. , Espejo Alvaro 
Published: July 2018

SummaryThis multistudy research examines the unit‐level relationship between promotive voice behavior and management innovation. Study 1 utilizes multisource data from 62 work units and reports that willingness to discuss ideas mediates the unit‐level relationship between promotive voice and management innovation. The results of Study 1 also show that the unit's available resources make the relationship stronger between promotive voice and willingness to discuss ideas. Study 2 employs a scenario‐based design to constructively replicate and expand the results of Study 1, utilizing a sample of 100 working adults. The results of the second study also show that resource availability positively moderates the relationship between promotive voice and willingness to discuss ideas. Furthermore, Study 2 shows that the indirect effect of promotive voice on management innovation through willingness to discuss ideas is stronger when more resources are made available to the work units. This moderated‐mediation effect is shown to be significant using two different operationalizations of management innovation. The implications for theory and practice are discussed.
Transforming growth factor β mediates communication of co‐cultured human nucleus pulposus cells and mesenchymal stem cells
Authors: Lehmann Tomasz P. , Głowacki Jakub , Harasymczuk Jerzy , Jagodziński Paweł P. 
Published: July 2018

ABSTRACTIntervertebral disc (IVD) consists of surrounding tissue annulus fibrosus and central nucleus pulposus, which are partially degenerative in scoliotic IVDs. Successful regeneration of scoliotic alterations requires cognition of critical paracrine mediators of cell‐to‐cell contact in the IVD. In this work, we hypothesized that transforming growth factor β (TGF‐β) is involved in the intercellular communication of nucleus pulposus cells (NPCs) and mesenchymal stem cells (MSCs). We observed that in cultured NPCs TGF‐β1 stimulated COL1A1 expression, encoding collagen I, and in MSCs stimulated COL1A1 and SOX9 expressions. We subsequently co‐cultured NPCs and MSCs together using direct and indirect transwell systems. The expression of miR‐140 and miR‐145 were decreased in co‐cultured NPCs. We observed that direct co‐culture system stronger than the indirect system decreased expression of three miRNA. The expression of COL1A1, ACAN, encoding aggrecan, and SOX9 genes was increased in MSCs co‐cultured with NPCs. Co‐cultures were incubated with two inhibitors of TGF‐β type I receptor: SB‐431542 and SB‐525334. In co‐cultured NPCs, SB‐431542 and SB‐525334 annulated downregulation of miR‐140 and miR‐145. In MSCs these inhibitors diminished stimulation of COL1A1, ACAN, and SOX9. We concluded that stimulation of COL1A1, ACAN, and SOX9 in co‐cultured MSCs and regulation of miR‐140 and miR‐145 in NPCs were TGF‐β‐dependent and TGF‐β is involved in the communication of NPCs and MSCs in co‐culture. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3023–3032, 2018.
Feeding During Phases of Altered Mitochondrial Activity: A Theory
Authors: McKeever Liam , Bonini Marcelo , Braunschweig Carol 
Published: July 2018

AbstractDecisions surrounding the timing and dosing of nutrition support are made for thousands of ICU patients daily and yet remain a topic of controversy. Nutrition support designed to replenish resting energy expenditure (REE) early in critical illness has led to worse clinical outcomes in at least three recent prospective randomized clinical trials. Producing sufficient energy from nutrient substrates requires use of the mitochondrial electron transport chain (ETC). This process is functionally linked to the creation of a tightly regulated series of chemical messengers known as reactive oxygen species (ROS). In health, ROS are kept at low levels by a system of mitochondrial/cellular enzymes and antioxidants, allowing ROS to act as a signal for the redox health of the cell. In inflammatory conditions, however, this system is altered, leading to changes in the physiologic function of the ETC such that its usage produces greater ROS per unit of substrate. This increased ROS is capable of deactivating antioxidant systems, as well as activating further ROS‐producing pathways and stimulating localized inflammatory activity. We propose that exacerbation of this process at this time by the forced influx of exogenously acquired nutrient substrates leads to mitochondrial damage, amplified ROS production, increased inflammation, decreased ATP‐productive capacity, and, eventually, the death of the cell by either apoptosis or necrosis. Knowledge of this process is vital to determining the safe dosing and timing of nutrition support in the ICU. It is possible that the physiologic cost of meeting the REE under these conditions of mitochondrial stress may simply be too high. This paper details the proposed process by which inappropriately timed feeding in critically ill patients may damage the very mitochondria required for its utilization.
Tube Feeding with a Diabetes‐Specific Enteral Formula Improves Glycemic Control in Severe Acute Ischemic Stroke Patients
Authors: Shao Yuan , Heng Weiwei , Li Shanshan , Xu Yun , Hu Gang 
Published: July 2018

AbstractBackgroundGlycemic control is essential for managing acute stroke. This study evaluated the impact of a diabetes‐specific formula (DSF) on glycemic control in severe acute ischemic stroke patients.MethodsA randomized, prospective controlled trial was conducted in Nanjing Drum Tower Hospital. Acute ischemic stroke patients who scored > 10 on the National Institutes of Health Stroke Scale as well as had swallowing problems were randomized to group A, which received a diabetes‐specific enteral formula, and group B, which received a standard formula. Glycemic parameters were assessed at baseline and 7 days after admission.ResultsOne hundred four patients were enrolled in the study (group A, 53; group B, 51). Postprandial glucose parameters, including capillary glucose concentration from 8 hours to 16 hours after enteral nutrition (EN) consumption, incremental areas under the curve (iAUC0‐16 h), peak value, and mean glucose concentration, were significantly lower in group A than in group B following a 7‐day intervention period. Moreover, changes in HOMAIR after the 7‐day treatment were significantly higher in group A than in group B. No significant difference in the incidence of hypoglycemia, glycemic variability parameters, or nutrition parameters was found between the 2 groups, either at baseline or after treatment. There were no serious adverse events observed during the study.ConclusionA diabetes‐specific formula may improve acute‐term glycemic control in severe acute ischemic stroke patients.
Labially impacted maxillary canines after the closed eruption technique and orthodontic traction: A split‐mouth comparison of periodontal recession
Authors: Lee Ji Yeon , Choi Yoon Jeong , Choi Seong‐Ho , Chung Chooryung J. , Yu Hyung‐Seog , Kim Kyung‐Ho 
Published: July 2018

AbstractBackgroundLabially impacted maxillary canines may lack periodontal tissue after orthodontic traction. This study evaluated the periodontal status of labially impacted maxillary canines after the closed eruption technique followed by orthodontic traction and investigated pretreatment variables affecting periodontal changes.MethodsPatients with one labially impacted maxillary canine (impaction group) and one contralateral normal canine (control group) were selected retrospectively. Maxillary canine pretreatment variables (angle, depth, sector, and Nolla stage) were determined from initial panoramic radiography. Periodontal outcomes including sulcus probing depth, bone probing depth, keratinized gingiva width (KGW), attached gingiva width (AGW), clinical crown length (CCL), cemento‐enamel junction to alveolar crest (CEJ‐AC) distance, root length, and bone support were measured from radiographic and clinical examinations after treatment and compared between the two groups. Pretreatment variables affecting the periodontal outcomes were determined using linear regression analyses.ResultsFifty‐four patients (21 males and 33 females; mean age, 12.85 years) were enrolled. The KGW, AGW, and root length were shorter; the CCL and CEJ‐AC distance were longer; and the bone support on the interproximal sides was less in the impaction group than in the control group (P < 0.05). The root length was shorter with higher Nolla stages and the distal alveolar crest was lower with deep and mesially angulated impaction (P < 0.01).ConclusionsAfter the closed eruption technique, impacted canines exhibited slight but clinically insignificant periodontal recession compared with the contralateral normal tooth. The root developmental stage and pretreatment depth and angle may influence periodontal recession.
Lignite‐derived humic substances modulate pepper and soil‐biota growth under water deficit stress
Authors: Qin Kuan , Leskovar Daniel I. 
Published: July 2018

AbstractOrganic matter‐derived soil amendments containing humic substances (HS) have a functional role to improve plant growth and soil quality, but their response to water deficit stress is less reported, particularly in vegetable crops. This study assessed the impact of lignite‐derived HS on biota growth and evaluated their potential mitigative effects under water deficit stress in growth chamber and greenhouse environments. Bell pepper (Capsicum annuum L. cv. Revolution) plants were grown in sandy and clay soil previously mixed with lignite‐derived HS and subjected to four irrigation levels (20%, 40%, 60%, and 80%) based on soil water‐holding capacity. Plant growth traits, soil chemical properties, and microbial populations were measured and analyzed. HS increased plant root development and soil bacteria population in moderate and no stress conditions (60%, 80%). Physiologically, HS rapidly decreased leaf stomatal conductance and transpiration after imposing severe or mild stress (20%, 40%). The results indicate that HS transiently ameliorated plants exposed to water stress by reducing moisture loss. In addition, due to their capacity to improve plant root growth, soil nutrient cycling and microbial activity, application of HS might have long‐term benefits in agricultural systems.
Influence of ring‐opening reactions on the kinetics of cottonseed oil epoxidation
Authors: Cai Xiaoshuang , Zheng Jun Liu , Aguilera Adriana Freites , Vernières‐Hassimi Lamiae , Tolvanen Pasi , Salmi Tapio , Leveneur Sébastien 
Published: July 2018

AbstractProduction of epoxidized vegetable oils becomes more and more important because they are renewable, nontoxic, and biodegradable chemicals. At the industrial scale, the Prileschajew oxidation is used to produce epoxidized vegetable oils from the corresponding vegetable oils. This oxidation uses an oxygen carrier, which is a percarboxylic acid produced in situ in the aqueous phase, to epoxidize the unsaturated groups on the vegetable oils. One of the main drawbacks of this method is the presence of side reactions: ring‐opening reactions of the epoxide group. To minimize the ring‐opening reactions and to find the most suitable reactor configuration, it is essential to investigate deeply the different ring‐opening reactions.For this work, epoxidation of cottonseed oil by peracetic acid in a batch reactor was studied. By developing a suitable modeling strategy, the kinetic constants for the ring‐opening reactions by water, hydrogen peroxide and acetic and peracetic acids were estimated. It was found that ring opening by acetic and peracetic acids was faster than by water and hydrogen peroxide. Based on this model, it was found that a semibatch reactor where hydrogen peroxide and sulfuric acid were added is the most suitable configuration.
Bifurcation properties for a class of fractional Laplacian equations in
Authors: Alves Claudianor O. , de Lima Romildo N. , Nóbrega Alânnio B. 
Published: July 2018

AbstractThis paper concerns with the study of some bifurcation properties for the following class of nonlocal problems

urn:x-wiley:0025584X:media:mana201700284:mana201700284-math-0003where , , , is a positive continuous function, is a bounded continuous function and is the fractional Laplacian. The main tools used are the Leray–Shauder degree theory and the global bifurcation result due to Rabinowitz.
Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile
Authors: Cheng Yilong , He Chaoliang , Ren Kaixuan , Rong Yan , Xiao Chunsheng , Ding Jianxun , Zhuang Xiuli , Chen Xuesi 
Published: July 2018

AbstractAn advanced hydrogel that features facile formation and injectability as well as light‐controlled degradation profile is reported here. By modifying 4‐arm poly(ethylene glycol) (4‐arm PEG) with 2‐nitrobenzyl (NB) and phenol, the 4‐arm PEG precursor solutions could form enzymatically cross‐linked hydrogels in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The gelation time, mechanical strength, and porous structure could be simply tuned by the concentration of HRP and H2O2. Moreover, the hydrogels underwent controlled degradation under UV light irradiation via photo‐cleavage reaction of the NB ester bond. The hydrogels exhibited negligible cytotoxicity toward mouse fibroblast L929 cells in vitro and can be manipulated through injection in vivo.