bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Injury Definition and Surveillance Methodology on Measures of Injury Occurrence and Burden in Elite Volleyball
Authors: MacDonald Kerry , Palacios-Derflingher Luz Maria , Emery Carolyn , Meeuwisse Willem 
Published: August 2018

AbstractA time-loss injury definition continues to be the most widely used injury definition despite evidence that it fails to accurately capture overuse injuries. An overuse injury questionnaire, using an “all complaints” definition has been created to address the limitation of a time-loss definition. The main aim of this work was to determine the effect that injury definition and registration methodology has on the collection of knee injuries among elite level volleyball players. To reach this goal, seventy-two volleyball players were prospectively followed over 32-weeks. Time-loss injuries were captured using an individual injury report form (IIRF). Study participants completed an overuse injury questionnaire (mOIQ) via a weekly short message service (SMS). The IIRF captured 15 time-loss knee injuries in 72 study participants (20%). Based on the mOIQ, 84.7% of participants reported having a knee problem and 66.7% sustained a substantial knee problem. All IIRF knee injuries captured were also registered by the mOIQ. Agreement on the specific diagnosis occurred for 66.7% of injuries resulting in a moderate Kappa score of 0.51. In conclusion, an overuse injury questionnaire provided a greater understanding of the magnitude and burden of knee injuries in this population.
Colorectal MALT lymphoma: a rare clinical entity
Authors: Fischbach Wolfgang 
Published: August 2018

Abstract
Background Data on colorectal lymphoma in general and on MALT (mucosa-associated-lymphoid tissue) lymphoma, in particular are, very rare. There are no existing recommendations from current guidelines for how to manage these patients. We here report our experience from a clinical series.
Aim The aim of this study is to present clinical features and the endoscopic appearance of colorectal MALT lymphoma and therapeutic approaches.
Methods Seven patients (5 male and 2 female, aged 47 – 75 years) were diagnosed to have colorectal MALT lymphoma. All patients underwent a full staging work-up. A concurrent gastric MALT lymphoma was present in 2 patients. Follow-up was 37 (0 – 53) months.
Results Colorectal MALT lymphoma was diagnosed by screening or staging colonoscopy in 3 and 1 patient, revealing no clinical symptoms, respectively. Two patients complained about fatigue, obstipation, and a change in bowel habits. The endoscopic appearance of the MALT lymphoma comprised obstructive tumors (n = 2), polyps (n = 3), a flat lesion (n = 1), and vascular angiectasia (n = 1). In 6 cases, colorectal MALT lymphoma presented as a solitary lesion. Following endoscopic polypectomy, surgical resection, Helicobacter pylori eradication therapy, or systemic immune-chemotherapy, complete remission of lymphoma was achieved in 5 cases, while the outcome is unknown or cannot yet be estimated in 2 cases.
Conclusion A treatment and management approach based on the clinical and local presentation of the lymphoma and its involvement is proposed.
Endoscopic retrograde appendicitis techniques for the treatment of patients with acute appendicitis
Authors: Ye Li-Ping , Mao Xin-Li , Yang Hai , He Bi-Li , Zhu Lin-Hong , Zhang Yu 
Published: August 2018

Abstract
Objective The purpose of this study was to demonstrate the feasibility of endoscopic retrograde appendicitis therapy (ERAT) in treating patients with acute appendicitis.
Materials and methods Between January 2014 and December 2014, 22 patients with acute appendicitis underwent ERAT. Patient demographics, colonoscopy findings, endoscopic retrograde appendiceal radiography (ERAR) findings, and treatment outcomes of the ERAT and adverse events associated with ERAT were analyzed.
Results In this study, 22 patients with acute appendicitis underwent ERAT. The median age of the patients was 39.5 years. Colonoscopy findings included mucosal hyperemia and swelling of the appendiceal orifice and/or its surrounding mucosa (86.4 %, 19/22) and pus at the appendiceal orifice (40.9 %, 9/22). ERAR findings included irregular contour (76.2 %, 16/21), appendiceal lumen dilation (28.6 %, 6/21), appendiceal lumen stenosis (42.9 %, 9/21), and filling defect of the appendiceal lumen (23.8 %, 5/21). Deep intubation was successfully performed in 21 of the 22 patients (95.5 %). Sixteen patients underwent endoscopic appendiceal stent placement after endoscopic appendiceal irrigation (EAI) due to lumen stenosis of the appendiceal, excessive pus, or appendiceal fecalith, and the remaining 6 patients only underwent EAI. Among the 22 patients who underwent ERAT, their abdominal pain was noticeably relieved following the procedure. The main adverse events associated with ERAT were spontaneous discharge of the stent, recurrent abdominal pain, and recurrent appendicitis. During the follow-up (median 33 months), 2 patients underwent laparoscopic appendectomy.
Conclusions ERAT provide a new alternative therapeutic method for patients with acute appendicitis, particularly for certain patients who are unwilling to undergo an appendectomy.
The Role of Brain Connectome Imaging in the Estimation of Depressive Relapse Risk
Authors: Brandl Felix , Meng Chun , Zimmer Claus , Sorg Christian 
Published: August 2018

Background About two-thirds of all patients with major depressive disorder (MDD) suffer from depressive relapse, the mechanisms of which are still poorly understood. In recent years, analyses of the brain’s connectome have increasingly been employed to identify potential biomarkers of depressive relapse. The term “connectome” refers to the map of all structural or functional connections in the brain. It can be investigated by structural or functional magnetic resonance imaging followed by graph theory-based analysis to characterize network topology on the global and regional level.
Methods This review is based on a selective literature search in PubMed representing the current state of research, as well as on an already published study which was awarded the Promotionspreis of the Deutsche Röntgengesellschaft.
Results and Conclusion Numerous studies point to altered network topology, e. g., of default-mode network and striatum, as being crucial for the pathophysiology of MDD. Our group was able to show that striatal centrality (or hubness) is associated with the number of depressive episodes, which is one of the best predictors for depressive relapse. These data suggest aberrant striatal network topology as a potential biomarker for depressive relapse risk. The translation of these promising findings into clinical routine diagnostics is promoted by several methodological advantages, while some unresolved issues still hinder this process.
Key points
Citation Format
Structured Reporting in Clinical Routine
Authors: Pinto dos Santos Daniel , Hempel Johann-Martin , Mildenberger Peter , Klöckner Roman , Persigehl Thorsten 
Published: August 2018

Background The radiology report is the key component in the communication between radiologists and referring clinicians. Traditionally, reports are written as free text. Several studies have shown that structured reporting using dedicated report templates has a number of advantages compared to conventional reports. Therefore, many radiological societies have recommended the implementation of structured reporting in clinical routine.
Method In the meantime, collections of freely available templates have been presented and software solutions for structured reporting have been made commercially available. These allow for quality improvements in the written radiology report as they ensure that all relevant clinical information is included. Most vendors mainly supply proprietary report templates or allow users to create templates for their own institution. The German Radiological Society (DRG) has the goal of developing consensus-based, quality-assured report templates and providing them under a free license.
Results The DRG has developed its first consensus-based report templates and provides them at www.befundung.drg.de. Further report templates will be developed in close cooperation with the respective committees of the DRG and referring clinicians.
Conclusion Structured reporting allows for a significant improvement in the quality of written radiology reports. The use of report templates requires personal and technical changes to the reporting process itself. Radiology should face these challenges in its leading role in the application of modern IT-based solutions. Vendors are now encouraged to provide practical solutions.
Key Points:
Citation Format
Contrast-Enhanced Ultrasound for Early Prediction of Response of Breast Cancer to Neoadjuvant Chemotherapy
Authors: Lee Youn , Kim Sung , Kang Bong , Kim Yun 
Published: August 2018

Abstract
Purpose To evaluate the time-intensity curve (TIC) parameters on contrast-enhanced ultrasound (CEUS) for early prediction of the response of breast cancer to neoadjuvant chemotherapy (NAC).
Materials and Methods This prospective study included 41 patients with breast cancer. CEUS was performed before and after the first cycle of NAC. TIC parameters were analyzed for different regions of interest (ROIs). ROI 1 targeted the hotspot area of greatest enhancement, ROI 2 delineated the area of hyperenhancement, ROI 3 included the entire tumor on grayscale ultrasound, and ROI 4 encircled the normal parenchyma. The TIC perfusion values for ROI 1, 2, and 3 were divided by the ROI 4 value.
Results 11 (26.8 %) of the 41 patients showed a good response (Miller-Payne score 4 or 5) and 30 (73.2 %) showed a minor response (Miller-Payne score 1, 2, or 3). There were significant differences in the wash-out area under the curve, the wash-in and wash-out areas under the curve on ROI 1/4 after the first cycle of NAC, pre-NAC mean transit time local (mTTl) on ROI 2/4, and pre-NAC mTTl on ROI 3/4 between good and minor responders (area under the receiver-operating characteristic curve > 0.70, p < 0.05).
Conclusion Some TIC parameters obtained by CEUS may allow prediction of the response of breast cancer to NAC at a very early time point.
In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats
Authors: Oskouei Bijan , Abbaspour-Ravasjani Soheil , Jamal Musavinejad Seyed , Ahmad Salehzadeh Seyed , Abdolhosseinzadeh Alireza , hamishehkar Hamed , Ghahremanzadeh Kazem , Shokouhi Behrooz 
Published: August 2018

Abstract
Aim The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats.
Materials and methods In this study, seven groups of the streptozotocin induced diabetic and normal rats (overall 42 males) were tested through various biochemical and histopathological factors such as: serum glucose, insulin, creatinine, lipids, lipoproteins, liver function-related enzymes, and antioxidant status in liver and kidney.
Results The obtained results in this work indicated that thymol had a significant anti-hypoglycemic, anti-hypolipidemic activities on the STZ-induced diabetic rats. Further, the assessment different biochemical parameters revealed that the levels of creatinine, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, and liver function-related enzymes such as aspartate aminotransferase and alanine aminotransferase were decreased in the treated diabetes rats under 20 and 40 mg/kg thymol compared to the control diabetes group. Considerably, the anti-oxidant enzymes status that were achieved from the liver and kidney organs were modulated after treatment with thymol in the diabetic rats.
Conclusion The results of this research has brough a new aspect concerning the proteevtive and positive effects of thymol on the diabetic complications in the animal model.
The Role of High-Fidelity Team-Based Simulation in Acute Care Settings: A Systematic Review
Authors: Armenia Sarah , Thangamathesvaran Loka , Caine Akia , King Neil , Kunac Anastasia , Merchant Aziz 
Published: August 2018

Introduction High-fidelity team-based simulation has been identified as an effective way of teaching and evaluating both technical and nontechnical skills. Several studies have described the benefits of this modality in a variety of acute care settings, but a lack of standardized methodologies has resulted in heterogeneous findings. Few studies have characterized high fidelity simulation across a broad range of acute care settings and integrated the latest evidence on its educational and patient impact.
Methods The MEDLINE, EMBASE, Cochrane Library, and PsycINFO databases were searched for empirical studies from the last 10 years, investigating high fidelity team-based simulation in surgical, trauma, and critical care training curricula.
Results Seventeen studies were included. Interventions and evaluations were comprehensively characterized for each study and were discussed in the context of four overarching acute care settings: the emergency department/trauma bay, the operating room, the intensive care unit, and inpatient ad hoc resuscitation teams.
Conclusions The use of high-fidelity team-based simulation has expanded in acute care and is feasible and effective in a wide variety of specialized acute settings, including the emergency department/trauma bay, the operating room, the intensive care unit, and inpatient ad hoc resuscitation teams. Training programs have evolved to emphasize team-based, multidisciplinary education models and are often conducted in situ to maximize authenticity. In situ simulations have also provided the opportunity for system-level improvement and discussions of complex topics such as social hierarchy. There is limited evidence supporting the impact of simulation on patient outcomes, sustainability of simulation efforts, or cost-effectiveness of training programs. These areas warrant further research now that the scope of utilization across acute care settings has been characterized.
Reticulated Platelets: Changing Focus from Basics to Outcomes
Authors: Hannawi Bashar , Hannawi Yousef , Kleiman Neal 
Published: August 2018

AbstractPlatelets play an essential role in the pathophysiology of atherothrombosis. Reticulated platelets (RPs) are the youngest platelet population in the circulation; their presence is an indicator of platelet turnover. Circulating levels of RPs are increased in patients with coronary artery disease and stroke. Preliminary indications are that the proportion of circulating RP is associated with the likelihood of ischaemic events such as acute coronary syndrome and stroke. Plausible mechanisms include: (1) increased participation of these platelets in thrombosis due to messenger ribonucleic acid that may be translated to active proteins, (2) lack of exposure to anti-platelet drugs since they are newly released from the bone marrow or (3) their presence is a non-specific marker of inflammation. In this state-of-the-art review, we discuss the implication of RP in coronary artery disease and in hypo-responsiveness to the most commonly used anti-platelet drugs.
Proximity to the Diaphragm Predicts the Presence of Rhabdomyomatous Dysplasia in Congenital Pulmonary Airway Malformations
Authors: Monteagudo Julie , Dickinson Catherine , Wakeley Michelle , Mangray Shamlal , Wills Hale , Luks Francois 
Published: August 2018

Introduction Rhabdomyomatous dysplasia (RD) is a pathologic finding in CPAMs that was incorrectly attributed to their malignant potential. The increasing recognition of extrathoracic (intradiaphragmatic and intraabdominal) congenital pulmonary airway malformations (CPAMs) offers a clue to the origin of RD. We hypothesize that the presence of RD is related to the CPAM's anatomic location.
Materials and Methods Retrospective review was performed of all children who underwent resection of a CPAM during a 10-year period. The age at the time of operation, location of the CPAM, and pathologic findings were collected. Peridiaphragmatic location was defined as within the inferior pulmonary ligament, deep to the diaphragmatic portion of the parietal pleura (“intradiaphragmatic”) or adjacent to the abdominal side of the diaphragm. Statistical analysis was performed using Fisher's exact test for 2 × 2 tables.
Results Twenty-six patients with CPAM were identified. Preoperative imaging was performed by computed tomography (CT) scan (16/26), ultrasound (5/26), magnetic resonance imaging (MRI) (1/26), and chest radiograph (4/26). The median age at resection was 15 months. Of these, 16 were pure cystic adenomatoid malformations, 4 were extralobar sequestrations, 4 were intralobar sequestrations, and 2 were bronchogenic cysts. Nine lesions were peridiaphragmatic with four being intradiaphragmatic (44%). Eight of the nine resected peridiaphragmatic lesions contained histologic evidence of rhabdomyomatous changes (89%, confidence interval [CI] 52–99%). None of the other lesions contained RD (CI 0–19%, p < 0.001).
Conclusion RD was seen exclusively, and in virtually all peridiaphragmatic CPAMs. While the exact significance of RD remains unclear, it may represent incorporation of striated muscle tissue associated with the developing diaphragm.
Apixaban versus Dalteparin for the Treatment of Acute Venous Thromboembolism in Patients with Cancer: The Caravaggio Study
Authors: Agnelli Giancarlo , Becattini Cecilia , Bauersachs Rupert , Brenner Benjamin , Campanini Mauro , Cohen Alexander , Connors Jean , Fontanella Andrea , Gussoni Gualberto , Huisman Menno , Lambert Catherine , Meyer Guy , Muñoz Andres , Abreu de Sousa Joaquim , Torbicki Adam , Verso Melina , Vescovo Giorgio ,   for the Caravaggio Study Investigators
Published: August 2018

AbstractInternational and national guidelines recommend low-molecular-weight heparin for the treatment of venous thromboembolism (VTE) in patients with cancer. The aim of the Caravaggio study is to assess whether oral apixaban is non-inferior to subcutaneous dalteparin for the treatment of acute proximal deep vein thrombosis and/or pulmonary embolism in patients with cancer. The study is an investigator-initiated, multi-national, prospective, randomized, open-label with blind end-point evaluation (PROBE), non-inferiority clinical trial (NCT03045406). Consecutive patients are randomized to receive oral apixaban or subcutaneous dalteparin for 6 months. Apixaban is given at a dose of 10 mg twice daily for the first 7 days and then 5 mg twice daily; dalteparin is given at a dose of 200 IU/kg for the first month and then 150 IU/kg once daily. The primary outcome of the study is objectively confirmed recurrent VTE as assessed by a central independent adjudication committee unaware of study treatment allocation. The primary safety outcome is major bleeding defined according to the guidelines of the International Society of Thrombosis and Haemostasis. Assuming a 6-month incidence of the primary outcome of 7% with dalteparin and an upper limit of the two-sided 95% confidence interval of the hazard ratio below the pre-specified margin of 2.00, 1,168 patients will be randomized considering an up to 20% loss in total patient-years (β = 80%; α one-sided = 0.025). The Caravaggio study has the potential, along with other recently performed or on-going studies, to make less cumbersome the management of VTE in patients with cancer by replacing parenteral with oral anticoagulation.
Die posttraumatische Belastungsstörung (PTBS) nach dem ICD-11 Kriterienvorschlag bei inhaftierten Männern
Authors: Krammer Sandy , Maercker Andreas , grosse Holtforth Martin , Gamma Alex , Liebrenz Michael 
Published: August 2018

Zusammenfassung
Theoretischer Hintergrund Die voraussichtlich 2018 erscheinende elfte Version des ICD führt nach der online einsehbaren Betaversion zu veränderten Kriterien hinsichtlich der posttraumatischen Belastungsstörung (PTBS). Solche Veränderungen wirken sich voraussichtlich auf bisher bekannte Merkmale der PTBS aus, darunter auch die Prävalenzrate. Die vorliegende Studie überprüfte die Häufigkeit der ICD-11 PTBS bei inhaftierten Männern, wozu bislang kein Wissen vorliegt. Dabei handelt es sich um eine Hochrisikogruppe für Traumafolgestörungen, denn gegenüber der Allgemeinbevölkerung sind diese besonders häufig von traumatischen Ereignissen betroffen.
Methode Bei n = 49 in der Schweiz inhaftierten Männern erfolgte querschnittlich und anhand von standardisierten Selbstbeurteilungsverfahren (ACE, Cidi-Liste, IES-R) die Erfassung von traumatischen Ereignissen und möglicher Traumafolgesymptomatik. Auf Basis der diagnostischen Heuristik von Hyland et al. (2017), anhand welcher die ICD-11 PTBS mittels der IES-R eingeschätzt wird, erfolgte die Berechnung der Häufigkeit eben dieser.
Ergebnisse Insgesamt waren 88 % der untersuchten inhaftierten Männer in der Kindheit und/oder über die Lebensspanne traumatisiert worden. 78 % berichteten mindestens ein Ereignis auf der ACE, durchschnittlich 1.5, 25 % schilderten vier oder mehr Ereignisse. Mit 51 % wurde emotionaler Missbrauch am häufigsten berichtet. Weiter gaben 71 % mindestens ein Ereignis auf der Cidi-Liste an, durchschnittlich 1.8, am häufigsten mit 45 % ernsthafte körperliche Bedrohung. Die Analyse zur ICD-11 PTBS wurde nach Ausschluss derjenigen ohne traumatischem Ereignis und derjenigen, die das IES-R nicht ausgefüllt hatten, mit n = 34 Inhaftierten durchgeführt und die PTBS wurde bei 26.5 % eingeschätzt.
Schlussfolgerung Die Studie zeigt, dass inhaftierte Männer wahrscheinlich auch nach dem neuen ICD eine Hochrisikogruppe für die Entwicklung einer PTBS sind. In Anbetracht der ausgeprägten Häufigkeit an traumatischen Ereignissen und den zahlreichen damit einhergehenden negativen Konsequenzen sowohl für die psychische als auch für die körperliche Gesundheit sind spezifische psychotherapeutische Programme und ein Trauma informierter Strafvollzug notwendig.
How intermittent breaks in interaction improve collective intelligence
Authors: Bernstein Ethan , Shore Jesse , Lazer David 
Published: August 2018

SignificanceMany human endeavors—from teams and organizations to crowds and democracies—rely on solving problems collectively. Prior research has shown that when people interact and influence each other while solving complex problems, the average problem-solving performance of the group increases, but the best solution of the group actually decreases in quality. We find that when such influence is intermittent it improves the average while maintaining a high maximum performance. We also show that storing solutions for quick recall is similar to constant social influence. Instead of supporting more transparency, the results imply that technologies and organizations should be redesigned to intermittently isolate people from each other’s work for best collective performance in solving complex problems.
Human exonization through differential nucleosome occupancy
Authors: Li Yumei , Li Chen , Li Shuxian , Peng Qi , An Ni A. , He Aibin , Li Chuan-Yun 
Published: August 2018

Significance
Nucleosomal modifications have been implicated in fundamental epigenetic regulation, whereas the roles of nucleosome binding in shaping changes through evolution remain to be addressed. Here we performed a comparative study to clarify the roles of nucleosome occupancy in exon origination. By profiling a high-resolution, cross-species mononucleosome landscape for mammalian tissues, we found nucleosome occupancy profiles are conserved across tissues and species. Further, through a phylogenetic approach, we found that the feature of differential nucleosome occupancy appears prior to the origination of new exons and, presumably, facilitates the origin of new exons by increasing the splice strength of the ancestral nonexonic regions through driving a local difference in GC content, which suggests the function of nucleosome binding in exonization.