bluuebunny/crossref_metadata_2025_split huggingface dataset:
Justification of pathogenetic mechanisms of ungulomycosis in cows
Authors: Khomyn N. M. , Pritsak V. V. , Ihlitskyi I. I. 
Published: November 2024

The article presents the results of biochemical, biophysical, and histomorphological studies of the hoof horn of clinically healthy cows and patients with purulent pododermatitis complicated by keratomycetes. It is known that the development of the inflammatory process in the area of the hooves, in particular, due to purulent inflammation of the producing layer of the base of the skin, complicated by keratomycetes, affects not only the animal body as a whole but also the quality of the hoof horn, which is characterized by changes in its individual biochemical and biophysical indicators and the structure of the epidermis of the hooves. In particular, in the hoof horn of animals with ungulomycosis, there is a probable increase of 35.6 % in the concentration of SH-groups and 16.1 % in the moisture content, which indicates the deterioration of the keratinization process and, as a result, the accumulation of excessive moisture content in the epidermis of the hooves. It indicates a deterioration in the quality of the hoof horn. It has been established that the condition of the hoof horn is influenced by other biochemical indicators, in particular, the concentration of Sulfur and Calcium in the epidermis of the hoof. Thus, with ungulomycosis, the content of Sulfur decreases by 19.2 %, and calcium decreases by 13.9 %, which indicates the deterioration of keratinization processes. Trace elements, particularly copper and zinc, also play an important role in this process. Purulent inflammation of the producing layer of the base of the skin of the hoofs, complicated by keratomicetes, decreases the concentration of these mineral substances by 18.1 and 16.2 %, respectively. Changes in the biochemical indicators of the epidermis of the cow's hooves due to ungulomycosis also affected its biophysical properties. Thus, hoof horn density decreased by 7.4 % and hardness by 17.8 %. It was established that in the presence of dystrophic and inflammatory processes at the base of the skin of the hooves, there are certain violations of the tissue (tubular) and cellular structure due to ungulomycosis. The horn of such hooves undergoes parakeratotic changes; loosening of fibers and destruction of cellular elements is observed. Thus, purulent pododermatitis of fungal origin is accompanied by changes in specific biochemical and biophysical parameters of the hoof horn, as well as histomorphological changes. These changes lead to irreversible processes in the epidermis of the hoofs and are one reason for the transition of the inflammatory process to deeper tissues and the involvement of the entire cow's hoof in this process.
Gastrointestinal parasites of dogs, analysis of prevalence and treatment efficacy
Authors: Mushynskyi A. B. , Karchevska T. M. , Prosyanyi S. B. , Kernychnyi S. P. , Savchuk L. B. 
Published: November 2024

The study of the prevalence of gastrointestinal parasites in dogs and the efficacy of anthelmintic drugs is a pressing issue in veterinary medicine. Helminthic infections can affect various systems of the animal's body, including the gastrointestinal tract, lungs, and other organs, often leading to severe diseases. This article presents the results of an examination of 97 dogs aimed at identifying gastrointestinal parasitic infections and evaluating the efficacy of various anthelmintic drugs. The analysis of fecal samples revealed that 53 % of the dogs were infected with one or more species of parasites. Four species of parasites were identified: three species of helminths (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala) and one species of protozoan parasite (Giardia spp.). The highest prevalence of infection was recorded for T. canis (51%), and mixed infections involving two or more parasites were found in 27 % of the dogs. The study demonstrated a significant age-related variation in infection rates: puppies (≤ 6 months) had the highest prevalence (61 %), while the rates in young dogs (6 months – 1 year) and adult dogs (over 1 year) were 57.1 % and 26.4 %, respectively. Among the parasites affecting puppies, T. canis (45.4 %) and Giardia spp. (12.6 %) were the most prevalent, indicating their high susceptibility to these infections. Additionally, it was found that female dogs were more frequently infected with parasites than males. The efficacy of anthelmintic drugs varied depending on the type of infection. The drugs Brovadazole and Wormidex were 100 % effective in cases of mono-infections; however, their efficacy decreased in cases of mixed infections. The efficacy of Albentabs ranged from 32 % to 61 % in mixed helminth infections but reached 100 % in mono-infections. Metronidazole was found to be 100 % effective against the protozoan parasite Giardia spp. The results of this study highlight the importance of early diagnosis and appropriate treatment of gastrointestinal parasitoses in dogs, especially in puppies, to prevent severe complications. The efficacy of anthelmintic drugs can vary significantly depending on the type of infection and the number of parasites, underscoring the need for an individualized approach to treating animals. Combining different classes of anthelmintic drugs may be more effective than using a single drug, as this approach allows for broader coverage of diseases and reduces the risk of resistance development.
Black nurses in the nursing profession in Canada: a scoping review
Authors: Jefferies Keisha , States Chelsa , MacLennan Vanessa , Helwig Melissa , Gahagan Jacqueline , Bernard Wanda Thomas , Macdonald Marilyn , Tomblin Murphy Gail , Martin-Misener Ruth 
Published: November 2024

<p><strong>Background</strong></p>
<p>With migration occurring over a series of centuries, dating back to the 1600’s, the circumstance regarding Black people in Canada is a complex account. A plethora of social issues and the failure to adequately acknowledge and reconcile historical issues, has resulted in health inequity, disparities and knowledge gaps, related to the Black population in Canada. In nursing, historical records indicate a legacy of discrimination that continues to impact Black nurses. The profession has begun reckoning with anti-Black racism and the residual effects. This scoping review sought to chart the existing evidence on Black nurses in the nursing profession in Canada. </p>
<p><strong>Methods </strong></p>
<p>JBI methodology was used to search peer-reviewed evidence and unpublished gray literature. Sources were considered for inclusion based on criteria outlined in an a priori protocol focusing on: 1) Canada 2) Black nurses and 3) nursing practice. No restrictions were placed on date of publication and language was limited to English and French. All screening and extractions were completed by two independent reviewers. </p>
<p><strong>Results </strong></p>
<p>The database search yielded 688 records. After removing duplicates, 600 titles and abstracts were screened for eligibility and 127 advanced to full-text screening. Eighty-two full-text articles were excluded, for a total of 44 sources meeting the inclusion criteria. Seven sources were identified through gray literature search. Subsequently, 31 sources underwent data extraction. Of the 31 sources, 18 are research (n = 18), six are commentaries (n = 6); one report (n = 1) and six are classified as announcements, memoranda or policy statements (n = 6). The review findings are categorized into five conceptual categories: racism (n = 12); historical situatedness (n = 2); leadership and career progression (n = 7); immigration (n = 4); and diversity in the workforce (n = 4). </p>
<p><strong>Conclusions </strong></p>
<p>This review reveals the interconnectedness of the five conceptual categories. Racism was a prominent issue woven throughout the majority of the sources. Additionally, this review captures how racism is exacerbated by intersectional factors such as gender, class and nationality. The findings herein offer insight regarding anti-Black racism and discrimination in nursing as well as suggestions for future research including the use of diverse methodologies in different jurisdictions across the country. Lastly, the implications extend to the nursing workforce in relation to enhancing diversity and addressing the ongoing nursing shortage. </p>
Evaluation of the experiences and needs of users of a drug information resources website
Authors: Isenor Jennifer E. , Helwig Melissa , Weale Michael B. , Bowles Susan K. 
Published: November 2024

<p>Objective: This article describes the evaluation of the experiences and needs of users of the Drug Information Resources (DIR) website. The DIR website attracts traffic and use from around the world with the highest users in Canada and the United States.</p>
<p>Methods: An online questionnaire was developed through literature review and Google Analytics data. Face validity testing and test-retest reliability were completed prior to releasing the questionnaire.</p>
<p>Results: Although the Google Analytics data showed that the site is used internationally, most respondents were Canadian students. They used the site for academic and clinical purposes and reported it was easy to use, well organized, include required resources, and would recommend it to others. </p>
<p>Conclusion: DIR was found to be a valuable resource for educational and clinical use. Future studies will aim to obtain input from international users. </p>
Mobile Device Use in Pharmacy: A Multi-Institutional Study
Authors: Duncan Vicky , Vokey Sherri , Gordon Shannon , Helwig Melissa , Chatterley Trish 
Published: November 2024

<p>Although there are studies that explore the use of mobile devices by physicians and pharmacists, there has not been a study to date that examines the prevalence and usage patterns of mobile devices amongst pharmacy students and faculty. This is the first pan-Canadian study that examines the prevalence and patterns of use of mobile devices by pharmacy faculty and students at Anglophone and Francophone universities. Unlike previous studies, this study also included interviews with participants to collect richer data than can be gathered with an online survey alone. </p>
Analisis Faktor yang Berhubungan dengan Harga Diri pada Mahasiswa Keperawatan Universitas Nasional
Authors: Sahira Adinda , Aisyiah Aisyiah , Suralaga Cholisah 
Published: November 2024

ABSTRACT Adolescence is a transition phase, where a person faces changes from one phase of development to the next. A common problem that occurs as a teenager is low self-esteem. Factors that have an impact on self-esteem involve gender, social and economic aspects, age, environmental conditions, family, peers and body mass index. This research aims to know connection between support family, support Friend peer, kind gender, index period body and factor environment with price self student nursing Faculty Knowledge Health University National. Study This use design study cross- sectional. Technique taking sample use technique proportional random sampling with involving 203 respondents. Research instrument This consists from questionnaire price self, questionnaire support Friend peers, questionnaire support family and questionnaire factor environment. Questionnaire This has tested validity and reliability with mark cronbach's alpha > standard cronbach alpha. Data analyzed use chi-square for know exists connection between variable. There is connection between index mass body with price self (ρ value = 0.049) And there is connection between support family with price self (ρ value = 0.007). There is a relationship between body mass index and family support and self-esteem. Keywords: Family Support, Peer Support, Environmental Factors, Self-Esteem ABSTRAK Masa remaja merupakan fase transisi, dimana seseorang menghadapi perubahan dari satu fase perkembangan menuju fase selanjutnya. Masalah yang umum terjadi saat remaja adalah rendahnya harga diri. Faktor yang memiliki dampak pada harga diri melibatkan jenis kelamin, aspek sosial dan ekonomi, usia, kondisi lingkungan, keluarga, teman sebaya dan indeks massa tubuh. Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga, dukungan teman sebaya, jenis kelamin, indeks masa tubuh dan faktor lingkungan dengan harga diri mahasiswa keperawatan Fakultas Ilmu Kesehatan Universitas Nasional. Penelitian ini menerapkan metode cross-sectional dalam desain penelitiannya. Pengambilan sampel dilakukan dengan menggunakan teknik propotional random sampling yang melibatkan partisipasi 203 responden. Instrument penelitian ini terdiri dari kuesioner harga diri, kuesioner dukungan teman sebaya, kuesioner dukungan keluarga dan kuesioner faktor lingkungan. Validitas dan reliabilitas kuesioner ini telah di uji, dengan nilai cronbach’s alpha > cronbach alpha standart. Analisis data dilakukan menggunakan chi-square untuk mengidentifikasi hubungan antar variabel. Ada korelasi antara indeks massa tubuh dan harga diri (ρ value = 0,049), serta terdapat korelasi antara dukungan keluarga dengan harga diri (ρ value = 0,007). Ada hubungan antara indeks massa tubuh dan dukungan keluarga dengan harga diri. Kata Kunci: Dukungan Keluarga, Dukungan Teman Sebaya, Faktor Lingkungan, Harga Diri
Efektifitas Gymball untuk Menurunkan Nyeri Persalinan dan Kecemasan pada Ibu Bersalin Kala I di Yayasan Bumi Sehat Kabupaten Gianyar
Authors: Nadyutami Pande Putu Eka , Noriani Ni Ketut , Darmayanti Putu Ayu Ratna 
Published: November 2024

ABSTRACT One indicator of public health degree is the Maternal Mortality Rate (MMR) and the Infant Mortality Rate (IMR). Safe labour does not guarantee will be without any pain, aches and feelings of anxiety. Therefore, more pregnant women prefer the SC method to the normal labour method due to the fear of pain experienced during delivery. Reducing anxiety and pain during delivery can be done through pharmacological and non-pharmacological methods. One of the non-pharmacological methods is the use of a gym ball. The purpose of this study was to identify the effect of gym balls on reducing labour pain and anxiety in phase I labour women at Bumi Sehat Foundation in Gianyar Regency. This study employed an accidental sampling method and recruited 32 respondents through a non-probability sampling technique according to the inclusion and exclusion criteria. Findings indicated that the gym ball is proven effective during the first stage of labour to reduce the intensity of pain and anxiety with a p-value of 0.000 (0.001) <0.05. Gymball effectively reduces mothers' pain intensity and anxiety levels in the first stage of labour. Therefore, health workers as service providers are expected to disseminate information about using gym balls as non-pharmacological methods to reduce pain and anxiety during labour. Keywords: Gymball, Pain, Anxiety, Maternity ABSTRAK Salah satu indikator derajat kesehatan masyarakat yaitu Angka Kematian Ibu (AKI) dan Angka Kematian Bayi (AKB). Berlangsungnya persalinan yang aman bukan berarti persalinan tidak disertai dengan rasa nyeri, sakit dan perasaan rasa cemas. Oleh karena itu, lebih banyak ibu memilih melahirkan dengan metode SC dibandingkan melahirkan secara normal karena takut akan membayangkan rasa sakit, dan nyeri yang akan dialami selama proses melahirkan normal. Penanganan yang bisa dilakukan untuk mengurangi rasa kecemasan dan nyeri saat persalinan dapat dilakukan dengan metode farmakologi, maupun non-farmakologi. Adapun metode non-farmakologi salah satunya penggunaan gymball. Untuk mengetahui efektifitas gymball sebagai metode penurunan nyeri dan kecemasan pada persalinan kala I. penelitian ini menggunakan metode accidental sampling. Sampel penelitian sebanyak 32 responden dengan teknik non probability sampling sesuai dengan kriteria inklusi dan eksklusi. Terbukti bahwa gymball efektif diberikan selama persalinan kala I untuk menurunkan intensitas nyeri dan kecemasan dengan nilai p-value 0.000 (0,001) <0,05. Gymball efektif dalam menurunkan intensitas nyeri dan tingkat kecemasan ibu bersalin kala I. Sehingga diharapkan kepada petugas kesehatan sebagai pemberi pelayanan untuk menyebarluaskan informasi terkait penggunaan gymball sebagai teknik non-farmakologi dalam mengurangi nyeri dan cemas saat persalinan. Kata Kunci: Gymball, Nyeri, Kecemasan, Ibu Bersalin
Efektivitas Niacinamide Topikal terhadap Hidrasi Kulit pada Individu dengan Akne Vulgaris
Authors: Permatasari Nabila Jingga , Tan Sukmawati Tansil 
Published: November 2024

ABSTRACT Nowadays, many skincare products use niacinamide as their base ingredient. Niacinamide, also known as vitamin B3, has the potential to enhance ceramide synthesis and improve the skin barrier function. Due to those potentials, niacinamide can improve someone’s skin hydration level. To find out the efficacy of topical niacinamide on skin hydration levels on individuals with acne vulgaris. Through a quasi-experimental study design, this study was conducted for 21 days at 75 North Jakarta State High School with respondents of 59 people who are suffering from acne vulgaris. The method that was used to collect the data involves measuring the level of skin hydration of the face before and after niacinamide serum intervention was given to respondents aged 15-18 years old. According to Wilcoxon’s statistic test, a significant change was achieved between the rate of skin hydration prior to and after intervention with niacinamide serum for 21 days (p-value < 0,001) with pre-evaluation values of 32% and after 41,5%. Topical use of niacinamide can increase someone’s skin hydration level. Keywords: Niacinamide, Skin Hydration, Acne Vulgaris, Skincare ABSTRAK Dewasa ini, produk perawatan kulit banyak yang menggunakan niacinamide sebagai bahan dasarnya. Niacinamide atau vitamin B3 sendiri memiliki potensi untuk meningkatkan sintesis seramid dan memperbaiki fungsi penghalang kulit sehingga dapat meningkatkan hidrasi kulit. Untuk mencari efektivitas penggunaan niacinamide secara topikal terhadap tingkat hidrasi kulit pada individu dengan akne vulgaris. Melalui desain penelitian quasi-eksperimental, penelitian ini dilakukan selama 21 hari di SMA Negeri 75 Jakarta Utara dengan responden sebanyak 59 orang yang menderita akne vulgaris. Metode pengumpulan data melibatkan pengukuran tingkat hidrasi kulit wajah sebelum dan setelah pemberian intervensi serum niacinamide kepada responden berusia 15-18 tahun. Menurut uji statistik Wilcoxon didapatkan perubahan yang bermakna antara tingkat hidrasi kulit wajah sebelum dan sesudah intervensi dengan niacinamide selama 21 hari (P-value < 0,001) dengan rerata sebelum intervensi sebesar 32% dan sesudah sebesar 41,5%. Penggunaan niacinamide secara topikal dapat meningkatkan hidrasi kulit. Kata Kunci: Niacinamide, Hidrasi Kulit, Akne Vulgaris, Perawatan Kulit
A wireless buckle transducer for measurement of human forearm tendon tension: operational principles and finite element study
Authors: Rastegarpanah Alireza , Taylor Stephen J. G. 
Published: November 2024

IntroductionConventional methods for evaluating the management of spasticity, a complex neuromuscular disorder, typically fail to directly measure the muscle forces and loads applied through tendons, which is crucial for accurate diagnostics and treatment. To bridge this gap, we developed a novel modular buckle transducer (BT) designed to measure tendon forces in vivo. This device adjusts to accommodate tendon sizes ranging from 3 mm to 5 mm, maintaining accuracy within this range and avoiding the need for identical tendon calibration.MethodsThis study first presents the mechanical principles for determining tendon tension T using several strain gauges appropriately positioned to allow for varying angles of passage of the tendon through the device. Next, we present a finite element (FE) model that uses multiple linear regression to determine T while varying tendon diameter and lateral placement within the device for several candidate strain gauge locations on the device base plate. Finally, we posit several alternative ways of combining gauge strains.ResultsInitial simulation results demonstrated that this placement facilitates effective pre-implementation calibration, with the device accommodating tendon variations from 3 mm to 5 mm in diameter for a range of gauge placements.DiscussionFuture validation of this technology will involve direct testing on explanted human/equine tendons to verify the practical utility of the BT, aiming to establish a new standard for assessing and managing neuromuscular disorders such as spasticity.
Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of (Ficus carica L.) from Eastern Morocco
Authors: Tikent Aziz , Laaraj Salah , Bouddine Toufik , Chebaibi Mohamed , Bouhrim Mohamed , Elfazazi Kaoutar , Alqahtani Ali S. , Noman Omar M. , Hajji Lhoussain , Rhazi Larbi , Elamrani Ahmed , Addi Mohamed 
Published: November 2024

IntroductionMany beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities.Methods, results, and discussion:HPLC-UV examination revealed that the leaf extract included mainly caffeine, rutin, and ferrulic acid. Spectrophometric results show that Malha leaf is rich in polyphenols (62.6 ± 1.3 mg GAE/g) and flavonoids (26.2 ± 0.1 mg QE/g). Chetoui leaf contains the highest vitamin C content (8.2 ± 0.1 mg Asc A/100 g DW), while Onk Hmam leaf has the highest condensed tannin (4.9 ± 0.1 mg CatE/g). The investigations found that all leaf extracts were antioxidant-rich, with strong Pearson bivariate correlation between bioactive polyphenol levels and antioxidant tests for DPPH, β-carotene, ABTS, and TAC (values of −0.93, −0.94, −0.85, and 0.98, respectively). The coefficients for flavonoid content were −0.89, −0.89, −0.97, and 0.80, respectively. Disk diffusion and MIC results show that the hydro-ethanol fig leaf extracts eliminate fungi and bacteria. In addition, these fig leaf extracts showed promise cytotoxicity against the breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-436 and an interesting selectivity index. In silico leaf bioactive component analysis revealed that myricitin inhibited NADPH oxidase the greatest (gscore −6.59 Kcal/mol). Trans-ferulic acid inhibits Escherichia coli beta-ketoacyl-[acyl carrier protein] synthase (−6.55 kcal/mol), whereas quercetin inhibits Staphylococcus aureus nucleoside diphosphate kinase (−8.99). CYP51 from Candida albicans is best treated with kaempferol and myricitin. Both had a glide gscore of −7.84 kcal/mol. Rutin has the most potent Sespace 3 anticancer activity, with a glide gscore of −7.09 kcal/mol.ConclusionThis research indicates that fig leaf extracts from the region can be used in medicine, food, natural cosmetics, and breast cancer prevention. To maximize the value of these leaves, their use must be carefully studied. Naturally, this fortunate tree’s diversity must be preserved and enhanced.