bluuebunny/crossref_metadata_2025_split huggingface dataset:
KARAKTERISTIK FISIK DAN SENSORIS CENDOL INSTAN DENGAN PENAMBAHAN CINCAU HIJAU (CYCLEA BARBATA L.)
Authors: Lestari Bayurini 
Published: July 2019

Penelitian ini bertujuan untuk mempelajari karakteristik fisik dan sensoris serta, menghitung laju peningkatan kadar air pada cendol instan dalam kemasan polypropylene pada suhu ruang. Perlakuan pada penelitian terdiri dari tiga taraf dengan tiga ulangan. Rancangan yang digunakan pada penelitian adalah rancangan acak kelompok faktorial dengan dua faktor perlakuan dan tiap perlakuan terdiri dari tiga taraf serta tiap perlakuan diulang tiga kali. Dua perlakuan terdiri dari konsentrasi penambahan ekstrak daun cincau hijau (A1 = 0 % , A2 = 10 % , A3 = 20 %) dan konsentrasi penambahan ekstrak daun suji dan pandan (B1 = 10 % , B2 = 20 %, B3 = 30 %).Parameter yang diamati meliputi tekstur, warna, pori-pori, lama rehidrasi serta uji sensoris dan uji difference from control. Hasil analisis keragaman menunjukkan bahwa penambahan ekstrak daun cincau hijau dan penambahan ekstrak daun suji dan pandan berpengaruh nyata terhadap tekstur dan berpengatuh tidak nyata terhadap warna, lama rehidrasi. Secara sensoris cendol instan yang disukai panelis yaitu dengan perlakuan A3B2(penambahan ekstrak daun cincau hijau 20% dan penambahan ekstrak daun suji dan pandan 20%). Karakteristik fisik A3B2adalah tesktur 44,00 gf, warna (kecerahan 62,03%, kehijauan -4,33, yellowness 22,80, total perbedaan warna 6,0), lama rehidrasi 2,62 menit, jumlah porositas pori besar 15,31% dan jumlah porositas pori kecil 84,69%).
PENGARUH MODEL PEMBELAJARAN THINK PAIR SHARETERHADAP KETERAMPILAN BERKOMUNIKASI SISWA PADA LARUTAN ELEKTROLIT DAN NON ELEKTROLIT
Authors: Experenza Prestin , Isnaini Muhammad , Irmita Luthfia 
Published: July 2019

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif tipe Think Pair Share terhadap keterampilan berkomunikasi siswa. Desain penelitian yang digunakan yaitu Posttest Only Control Group Design. Penelitian ini dilakukan pada semester genap yang dimulai tanggal 07 sampai 28 Januari 2019. Populasi dalam penelitian ini yaitu seluruh siswa kelas X MIA MA Patra Mandiri Palembang tahun pelajaran 2018/2019 yang terdistribusi dalam 3 kelas yaitu kelas X MIA 1, X MIA 2, dan X MIA 3. Sampel dalam penelitian ini diperoleh dengan menggunakan teknik pengambilan sampel yaitu teknik Purposive Sampling. Sampel penelitian ini yaitu siswa kelas X MIA 1 sebagai kelas eksperimen dan X MIA 3 sebaga kelas kontrol. Data keterampilan berkomunikasi siswa diperoleh melalui observasi, kuisioner, dan dokumentasi. Analisis data menggunakan uji Mann-Whitney dan taraf signifikansi = 5%. Hasil uji hipotesis Mann-Whitney sebesar Asymp.sig.(2-tailed) sebesar 0,000 <0,05. Hal ini berarti terdapat pengaruh model pembelajaran kooperatif tipe Think Pair Share terhadap keterampilan berkomunikasi siswa di kelas X MIA pada materi larutan elektrolit dan non elektrolit di MA Patra Mandiri Palembang.
IMPACT EXPORT DIVERSIFICATION ON EXCHANGE RATE REGIME CHOICE
Authors: Mayangsari Eka Putri 
Published: July 2019

ABSTRACT The choice of exchange rate regime is the most relevant decision in the economic world that has to be faced by the economic authority until now. Exchange rate regime that is applied by one country become a controversial debate after the Asia’s crisis in the year 1997-1998, especially for developing countries and emerging economies in Asia. The purpose of this research is to see the impact of export diversification, intensive margin and extensive margin to the choice of the exchange rate regime in nine emerging and developing countries in Asia 1991-2014.This research uses the panel logistic regression model to analyze the two model that are used in the research; they are: model 1 (the impact of export diversification to the exchange rate regime),and model 2 (the impact of extensive margin and intensive margin to the exchange rate regime. To avoid and to lessen the chances of endogeneity problem therefore, all of the independent variables and the control variable must be lagged in one period.The results of the regression shows that export diversification have a significant positive impact on the exchange rate regime. When export diversification is decomposed into intensive margin and extensive margins, the result shows that the extensive margins also have a significant positive impact towards the exchange rate regime, while the intensive margin does not show any significant impact towards the exchange rate regime choice. Keywords: exchange rate regime, export diversification, intensive margin, extensive margin, emerging and developing countries in Asia.
PRIMARY CARE: HOW TO INCREASE PHYSICAL ACTIVITY IN YOUR PATIENTS
Authors: Slobodyanyuk A. L. , Кrylova I. A. , Kupaev V. I. 
Published: July 2019

Sedentary lifestyle, being a behavioral risk factor for chronic non-communicable diseases, is relevant for preventive medicine. A key role in the correction of behavioral risk factors for chronic non-communicable diseases is occupied by general medical practice, where the patient is continuously observed for many years. Increased physical activity reduces the risk of atherosclerosis, diseases of the musculoskeletal system, malignant tumors, has a positive effect on the psychological state of patients and reduces the overall morbidity and mortality. Increasing the reserves of the cardiorespiratory system of the body, physical activity improves the quality of life of patients and reduces the cost of medical care.To effectively combat sedentary lifestyle, it is necessary to adequately motivate patients that can be achieved through routine counseling to enhance physical activity. The method of such consultation should take into account limited time of outpatient admission and all personal characteristics of patients (starting level of physical activity, health group and risk of disease).The article presents a summary of modern scientific views in the field of increasing physical activity of patients, discusses current issues of counseling. The groups of patients with or without chronic diseases and the high risk of cardiovascular complications were discussed. The variant of rational outpatient counseling with the help of the algorithm of organization of physical activity mode, providing stratification of patients, planning, optimization and control of personal motor activity was presented. The proposed method of optimization of counseling successfully solves the problems of motivation, increase of physical activity and individual approach in outpatient practice.
Shiny-Seq: Advanced Guided Transcriptome Analysis
Authors: Sundararajan Zenitha , Knoll Rainer , Hombach Peter , Becker Matthias , Schultze Joachim L. , Ulas Thomas 
Published: July 2019

Abstract
Objective

A comprehensive analysis of RNA-Seq data uses a wide range of different tools and algorithms, which are normally limited to R users only. While several tools and advanced analysis pipelines are available, some require programming skills and others lack the support for many important features that enable a more comprehensive data analysis. There is thus, a need for a guided and easy to use comprehensive RNA-Seq data platform, which integrates the state of the art analysis workflow.

Results

We present the tool Shiny-Seq, which provides a guided and easy to use comprehensive RNA-Seq data analysis pipeline. It has many features such as batch effect estimation and removal, quality check with several visualization options, enrichment analysis with multiple biological databases, identification of patterns using advanced methods such as weighted gene co-expression network analysis, summarizing analysis as power point presentation and all results as tables via a one-click feature. The source code is published on GitHub (https://github.com/schultzelab/Shiny-Seq) and licensed under GPLv3. Shiny-Seq is written in R using the Shiny framework. In addition, the application is hosted on a public website hosted by the shinyapps.io server (https://schultzelab.shinyapps.io/Shiny-Seq/) and as a Docker image https://hub.docker.com/r/makaho/shiny-seq.
The long-term efficacy of one-shot neoadjuvant intra-arterial chemotherapy combined with radical cystectomy versus radical cystectomy alone for bladder cancer: a propensity-score matching study
Authors: Wahafu Wasilijiang , Liu Sai , Xu Wenbin , Wang Mengtong , He Qingbao , Song Liming , Wang Mingshuai , Yang Feiya , Hua Lin , Niu Yinong , Xing Nianzeng 
Published: July 2019

Abstract
Background:
Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder cancer before radical cystectomy continues to be controversial. We compared the long-term efficacy of one-shot neoadjuvant intra-arterial chemotherapy (IAC) versus no IAC (NIAC) before radical cystectomy (RC) for bladder cancer.

Methods:
We performed a retrospective review of patients who underwent either one-shot IAC or NIAC before RC between October 2006 and November 2015. A propensity-score matching (1:3) was performed based on key characters. The Kaplan-Meier method was utilized to estimate survival probabilities, and the log-rank test was used to compare survival outcomes between different groups. A multivariable Cox proportional hazard model was used to estimate survival outcomes.

Results:
Twenty-six patients were treated using IAC before RC, and 123 NIAC patients also underwent RC. After matching, there was no significant difference between groups in baseline characteristics, perioperative variables, complication outcomes or tumor characteristics. Compared with clinical tumor stages, pathological tumor stages demonstrated a significant decrease (P=0.002) in the IAC group. There was no significant difference in overall survival (OS, p=0.354) or cancer-specific survival (CSS, p=0.439) between the groups. Among all patients and in the NIAC group, BMI significantly affected OS (p=0.004 and p=0.014, respectively), and positive lymph nodes significantly affected both OS (p＜0.001, both) and CSS (p=0.010 and p=0.017, respectively). Only diabetes involvement at the time of IAC was significantly associated with worse overall mortality (p=0.004).

Conclusions:
One-shot neoadjuvant IAC before RC shows safety and tolerability and provides a significant advantage in pathological downstaging but not in OS or CSS. Further study of neoadjuvant combination therapeutic strategies with RC is needed.
Evaluation of the ERCC2 (Lys751Gln), MSH2 (gIVS12-6TC), RAD54 (Ala730Ala), XPC (Lys939Gln), XPG (Asp1104Hist), XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) gene polymorphisms in the Ecuadorian population with retinoblastoma
Authors: Leone Paola E. , Guevara-Ramírez Patricia , Quevedo Silvana , Zumárraga Sonia , Armendáriz-Castillo Isaac , García-Cárdenas Jennifer M. , Guerrero Santiago , López-Cortés Andrés , Pérez-Villa Andy , Yumiceba Verónica , Zambrano Ana Karina , Miño César Paz y 
Published: July 2019

Abstract
Background

Retinoblastoma is a neoplasia that starts in the retina and may have inheritable or sporadic genetic predisposition. This affects children, mainly those who are under 5 years old. Approximately 9,000 new cases are diagnosed per year worldwide. In Ecuador this disease has an incidence of 1 per each 20,000 live births. The genetic predisposition to develop retinoblastoma is strongly influenced by RB1 gene, and may be influenced by the presence of genetic polymorphisms which intervene in the DNA repair system.

Methods

This study has analyzed the genotype frequency of ERCC2 (Lys751Gln), MSH2 (gIVS12-6TC), RAD54 (Ala730Ala), XPC (Lys939Gln), XPG (Asp1104Hist), XRCC1 (Arg399Gln), and XRCC3 (Thr241Met) polymorphisms of different repair genes, genotyping 90 individuals affected with retinoblastoma and 80 healthy individuals through polymerase chain reaction / restriction fragments length polymorphism and sequencing analysis.

Results

The presence of the (C/C) mutant homozygous genotype of XPC (Lys939Gln) polymorphism triggers a significant risk of developing retinoblastoma with an odds ratio (OR) of 3 (CI: 1.22-9.84; p < 0.05). Likewise, the A/G heterozygous genotype and the combination A/G+G/G of XRCC1 (Arg399Gln) polymorphism presented ORs of 9.7 (CI: 4.45-21.08; p < 0.001) and 7.55 (IC: 3.57-16; p < 0.001), respectively.

Conclusions

The genetic variants XPC (Lys939Gln) and XRCC1 (Arg399Gln) may be associated with the risk of developing retinoblastoma in the Ecuadorian population.
Prevalence of HPV infection among 157,038 Chinese females in Hunan Province, central-south China: Research article
Authors: Wang Chen , Xiao Songshu , He Sili , Pan Qiong , Zeng Jie , Xue Min 
Published: July 2019

Abstract
Background: In the present study, we aimed to investigate the human papillomavirus (HPV) infection rate in females of Hunan Province, China, as well as the common HPV genotype distribution. Moreover, we also explored the differences in HPV infections among females of different ages.
Methods: Clinical data were collected from 157,038 females who had tested HPV infection in the Third Xiangya Hospital of Central South University from November, 2010 to May, 2017.
Results: The overall HPV infection rate was 19.91%.The most commonly detected genotypes were HPV52 (4.62%), HPV16 (3.52%), HPV 58(3.12%), HPVCP8304 (2.91%), and HPV53 (2.06%). The highest infection rate was found in females under the age of 20 (30.33%), the second highest infection rate was found in females over the age of 60 (24.72%), and females aged 30-39 showed the lowest HPV infection rate (18.11%). In addition, 71.32% of the infections were single HPV infections. Among the multiple HPV infections, HPV16/HPV6 co-infection was the most commonly detected combination (0.52%).
Conclusions: In this study, we examined the epidemiology of HPV and the prevalence of the common HPV infection in Hunan Province, central-south China. We have revealed the prevalence and distribution of the different HPV types. Our study showed that females under the age of 20 and over the age of 60 were at higher risk of HPV infection than females of other ages. Moreover, our region should make extra efforts to the prevention and treatment of HPV52, HPV16 and HPV58 infections.
Where is an emotion? Using targeted visceroception as a method of improving emotion regulation in healthy participants to inform suicide prevention initiatives: a randomised controlled trial
Authors: Davey Steven , Bell Elliot , Halberstadt Jamin , Collings Sunny 
Published: July 2019

Abstract
Background
William James’ 1884 paper “What is an emotion?” has generated much recent interest in affective science regarding somatic contributions to emotion. Studies of interoception (“sensing the physiological condition of the body”) suggest that sensing specific parts of the body contribute to the production of emotion, namely when sensing the viscera (i.e. ‘visceroception’ of the heart, gut or lungs). Improved visceroception has, for instance, been linked to increased emotional intensity, suggesting a role for interoception in emotion regulation that may pertain specifically to visceral bodily locations. Thus, in addition to asking James’ question, “What is an emotion?”, we ask, “Where is an emotion?”. Further, there is an evidence base pointing to the connections between emotion regulation and suicide, and between interoception and suicide. The trial investigates whether targeted interoception/visceroception improves emotion regulation, the ultimate aim of which is to inform suicide prevention efforts.

Methods
The trial utilises a pre-test/post-test control group design, with two experimental groups undergoing visceroceptive interventions (gut or heart focus) and a control group. The interventions will run for 8 weeks. A spatial cueing task will measure reaction times to bodily changes pertaining to gut or heart focus. A stop/signal task will measure emotional inhibition, which is hypothesised to obscure awareness of active bodily locations. Visceroceptive ability will be tracked using a heartbeat estimation task, a water load test, and by self-report questionnaire. The sample consists of healthcare professionals and healthcare students (i.e. groups that represent a relatively high suicide risk among professional and student groups).

Discussion
To our knowledge, this will be the first project to address whether emotional feeling presents as a localised bodily phenomenon and whether trained awareness of emotional localisation can improve emotion regulation. It will also be the first to investigate relationships between interoception and emotional inhibition (i.e. whether a sustained interoceptive practice leads to the disinhibition of bodily emotional sensations, which can positively contribute to emotion regulation). These empirical findings on emotion regulation will be used to inform a desk-based enquiry into the role of embodied emotion in suicide prevention, which may make a significant contribution to a growing evidence base on interoception and suicide.
Can an observational gait scale produce a result consistent with 3-dimensional gait analysis?: a prospective observational study
Authors: Guzik Agnieszka , Drużbicki Mariusz , Perenc Lidia , Podgórska-Bednarz Justyna 
Published: July 2019

Abstract
Background: To investigate whether a simple observational tool may be a substitute to the time-consuming and costly 3-dimensional (3D) analysis, the study applied the Wisconsin Gait Scale (WGS), enabling assessment which is highly consistent with 3D gait parameters in individuals after stroke. The aim of this study was to determine whether, and to what extent, observational information obtained from WGS-based assessment can be applied to predict results of 3D gait analysis for selected symmetry indicators related to spatiotemporal and kinematic gait parameters.

Methods: Fifty individuals at a chronic stage of recovery post-stroke were enrolled in the study. The spatiotemporal and kinematic gait parameters were measured using a movement analysis system. The Symmetry Index (SI), was calculated for selected gait parameters. The study participants’ gait was evaluated by means of the WGS. The regression analysis was applied to investigate whether a simple observational tool may be a substitute to the time-consuming and costly 3D analysis.

Results: It was shown that 3D SI, related to Stance Time [s], Stance %, Hip and Knee Flexion-Extension Range of Motion may be described with fairly high accuracy using item questions of the WGS (0.7≤|R|<0.9; 0.9≤|R|<1). This initial finding provided a rationale for the assumption that a combination of selected WGS items may enable even more accurate estimation of SI for 3D parameters. It was shown that Stance % SI, Hip and Knee Flexion-Extension Range of Motion SI can most effectively be substituted by WGS-based estimations – coefficient of determination exceeding 80%.

Conclusions: It was shown that information acquired based on the WGS can be used to obtain results comparable to those achieved in 3D assessment for selected SIs of spatiotemporal and kinematic gait parameters. The study confirms that observation of gait using the WGS, which is an ordinal scale, is consistent with the main aims of 3D assessment, therefore the scale can be recommended as a substitute tool in gait assessment.

Trial registration: ANZCTR, ACTRN12617000436370. Registered 24 March 2017, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372248.
Role of inferior vena cava collapsibility index in the prediction of hypotension associated with general anesthesia: an observational study
Authors: Szabó Marcell , Bozó Anna , Darvas Katalin , Horváth Alexandra , Iványi Zsolt Dániel 
Published: July 2019

Abstract
Background: Intraoperative hypotension increases 30-day mortality and the risks of myocardial injury and acute renal failure. Patients with inadequate volume reserve before the induction of anesthesia are highly exposed. The identification of latent hypovolemia is therefore crucial. Ultrasonographic measurement of the inferior vena cava collapsibility index (IVCCI) is able to detect volume responsiveness in circulatory shock. No current evidence is available regarding whether preoperative measurement of the IVCCI could identify patients at high risk for hypotension associated with general anesthesia.
Methods: A total of 102 patients undergoing elective general surgery under general anesthesia with standardized propofol induction were recruited for this prospective observational study. The IVCCI was measured under spontaneous breathing. A collapsing (IVCCI≧50%) (CI+) and a noncollapsing (CI-) group were formed. Immediate postinduction changes in systolic and mean blood pressure were compared. The performance of the IVCCI as a diagnostic tool for predicting hypotension (systolic pressure <90 mmHg or a ≥30% drop from the baseline) was evaluated by ROC curve analysis.
Results: A total of 83 patients were available for analysis, with 20 in the CI+ and 63 in the CI- group, we excluded 19 previously eligible patients due to inadequate visualization of the IVC (7 cases), lack of adherence to the protocol (8 cases), missing data (2 cases) or change in anesthesiologic management (2 cases). The mean decrease in systolic pressure in the CI+ group was 53.8±15.3 compared to 35.8±18.1 mmHg in CI- patients (P=0.0001). The relative mean arterial pressure change medians were 34.1% (IQR 23.2%-43.0%) and 24.2% (IQR 17.2%-30.2%), respectively (P=0.0029). The ROC curve analysis for IVCCI showed an AUC of 64.8% (95%CI 52.1-77.5%). The selected 50% level of the IVCCI had a sensitivity of only 45.5% (95%CI 28.1-63.7%), but the specificity was high at 90.0% (78.2-96.7%). The positive predictive value was 75.0% (95%CI 50.9-91.3%), and the negative predictive value was 71.4% (95%CI 58.7-82.1%).
Conclusion: In spontaneously breathing preoperative noncardiac surgical patients, preoperatively detected IVCCI≧50% can predict postinduction hypotension with high specificity but low sensitivity. Despite moderate performance, IVCCI is an easy, noninvasive and attractive option to identify patients at risk and should be explored further.
First report of Mesocriconema sphaerocephalum (Taylor, 1936) Loof, 1989 associated with carrot (Daucus carota subsp. Stativus) in Vietnam
Authors: Nguyen Thi Duyen , Nguyen Huu Tien , Linh Le Thi Mai , Thu Tran Thi Tuyet , Nobleza Neriza , Trinh Quang Phap 
Published: July 2019

Abstract
Our study recorded the presence of Mesocriconema sphaerocephalum on carrot in Hanoi city and Hai Duong province in Vietnam. This species was identified by morphometric, morphological characterizations, and molecular characterization of D2D3 of 28S rDNA sequence. To our knowledge, this is the first report of M. sphaerocephalum on carrot in Vietnam.