bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tale of 2 Constituencies
Authors: Goytia Crispin N. , Kastenbaum Isaac , Shelley Donna , Horowitz Carol R. , Kaushal Rainu 
Published: August 2018

Background:Patient and clinician stakeholders are inadequately engaged in key aspects of research, particularly regarding use of Big Data to study and improve patient-centered outcomes. Little is known about the attitudes, interests, and concerns of stakeholders regarding such data.Research Design:The New York City Clinical Data Research Network (NYC-CDRN), a collaboration of research, clinical, and community leaders built a deidentified dataset containing electronic health records from millions of New Yorkers. Guided by a patient-clinician advisory board, we developed a question guide to explore patient and clinician experiences and ideas about research using large datasets. Trained facilitators led discussions during preexisting patient, community, and clinician group meetings. The research team coded meeting notes and identified themes.Results:Fully 272 individuals participated in 19 listening sessions (139 patients/advocates, 133 clinicians) at 6 medical centers with diverse NYC communities: 76% were female and 63% were nonwhite. Clinicians and patients agreed on all major themes including the central role of clinicians in introducing patients to research and the need for public campaigns to inform stakeholders about Big Data. Stakeholders were interested in using granular data to compare the care and clinical outcomes of their neighborhoods with others across NYC, but were also concerned that data could not truly be deidentified.Conclusions:Clinicians and patients agree on potential benefits of stakeholder-engaged Big Data research and provided suggestions for further research and building stakeholder research capacity. This evaluation demonstrated the potential of brief meetings with existing patient and clinical groups to explore barriers and facilitators to patient and clinician engagement.
JAK2 is highly expressed by cyst-lining cells and regulates cystogenesis
Authors: Patera Foteini , Cudzich-Mardy Alex , Huang Zhi , Fragiadaki Maria 
Published: August 2018

ABSTRACTDysregulated JAK/STAT signalling is implicated in polycystic kidney disease, which is a common genetic disease leading to renal failure. However, the mechanisms underlying JAK/STAT-mediated cystogenesis arepoorlyunderstood.TheroleofJAK2wasinvestigated immunohistochemically in a murine model of cystic disease (Pkd1nl/nl). In the normal kidney, JAK2 is restricted to tubular epithelial and vascular cells with lesser staining in bowman’s capsule and is undetectable in the interstitium. By contrast, in the diseased kidney JAK2 appears stronger in cyst-lining cells when compared to normal tubules and appears mislocalised in the interstitium. Given that JAK2 is a major tyrosine kinase activating JAK/STAT, we considered whether its inhibition can attenuate cystic growth in vitro. To assess this we used curcumin, a natural phytochemical, which significantly reduced JAK2 levels and STAT3 activity. Consistently, reduced JAK2/STAT3 activity was correlated with reduced cystic growth of cystic cells in three-dimensional cyst assays. Taken together, our results suggest that JAK2 is a key signalling molecule that functions to inhibit cystic growth in cystic tubular epithelial cells, thus providing the foundation for its development as a novel therapeutic in polycystic kidney disease.
Simulation of dynamic stall using direct-forcing immersed boundary method at low Reynolds number
Authors: Vaziri Nima , Chern Ming-Jyh , Horng Tzyy-Leng 
Published: August 2018

Purpose
The purpose of this study is simulation of dynamic stall behavior around the Eppler 387 airfoil in the low Reynolds number flow with a direct-forcing immersed boundary (DFIB) numerical model.

Design/methodology/approach
A ray-casting method is used to define the airfoil geometry. The governing continuity and Navier–Stokes momentum equations and boundary conditions are solved using the DFIB method.

Findings
The purposed method is validated against numerical results from alternative schemes and experimental data on static and oscillating airfoil. A base flow regime and different vortices patterns are observed, in accordance with other previously published investigations. Also, the effects of the reduced frequency, the pitch oscillation amplitude and the Reynolds number are studied. The results show that the reduced frequency has a major effect on the flow field and the force coefficients of the airfoil. On the other hand, the Reynolds number of the flow has a little effect on the dynamic stall characteristics of the airfoil at least in the laminar range.

Practical implications
It is demonstrated that the DFIB model provides an accurate representation of dynamic stall phenomenon.

Originality/value
The results show that the dynamic stall behavior around the Eppler 387 is different than the general dynamic stall behavior understanding in the shedding phase.
Analysis of the viscosity dependent parameters of couple stress fluid in porous parallel plates
Authors: Madalli V.S. , Patil Siddharama , Hiremath Ayyappa , Kudenatti Ramesh 
Published: August 2018

Purpose
This paper aims to present a detailed analysis to explore the various properties of non-Newtonian couple stress lubricants between parallel porous plates.

Design/methodology/approach
With reference to the theories based on micro-continuum analysis, a non-linear, non-Newtonian Reynolds type equation is arrived. The closed form solutions obtained clearly indicate the changes in pressure, load bearing capacity and response time because of variation in viscosity of couple stress fluid.

Findings
It is observed that the viscosity variation factor greatly influences the change in pressure, load carrying capacity and squeezing time.

Originality/value
It is observed that the nature of lubricants with suitable additives greatly helps in overcoming the adverse effect because of porous surface. Reynolds type equation is analysed using appropriate boundary conditions. The expression for pressure distribution arrived at in turn leads to the analysis of load bearing capacity and response time.
Post-materialistic values and entrepreneurial intention – the case of Saudi Arabia
Authors: Alammari Khalid , Newbery Robert , Haddoud Mohamed Yacine , Beaumont Emily 
Published: August 2018

PurposeThe purpose of this paper is to investigate how cultural values influence the entrepreneurial process. It conceptualises the relationship between post-materialistic values and entrepreneurial intention to explain low entrepreneurial activity.Design/methodology/approachThe study was conducted in Saudi Arabia with non-entrepreneurs. An online survey returned 405 valid questionnaires, representing a 27 per cent response rate. The data were analysed using partial least structural equation modelling.FindingsThe paper identifies key factors that explain the influence of changing cultural values on entrepreneurial activity. The results show that post-materialistic values influence entrepreneurial intention by decreasing desirability and entrepreneurial self-efficacy.Research limitations/implicationsThe study conceptualises the interplay between cultural values and entrepreneurial intention in Saudi Arabia. Further insights can be developed by comparing Saudi Arabia with other countries. The study was conducted as a “snapshot” of the current situation of entrepreneurship in Saudi Arabia with a cross-sectional survey design.Practical implicationsThe paper holds important implications for entrepreneurship educators when addressing unsupportive cultures for entrepreneurial activity. Cultural and motivational approaches are suggested. While the former focuses on aspects that encourage the desire and confidence to start a business, the latter involves encouraging setting venture creation as a goal.Originality/valuePrevious studies indicated that post-materialistic values negatively influence entrepreneurship; this paper contributes further by exploring how this relationship manifests by exploring the intervening factors between post-materialistic values and entrepreneurial intention. It advances entrepreneurship research by investigating deep assumptions underlying the formulation of entrepreneurial intentions. It also responds to the need to understand the difference in the levels of entrepreneurial activity across countries.
Emancipatory education and the preparation of future teachers
Authors: Winarti Eny 
Published: August 2018

Purpose
The purpose of this paper is to explore the possibilities and impact of emancipatory education in the preparation of future elementary school teachers.

Design/methodology/approach
To serve the purpose of the study, emancipatory education was introduced to the student teachers of an elementary school teacher education program in the Curriculum and Learning Development course. The researcher then observed them during their learning activities and analyzed their portfolios providing feedback during their poster presentations. A classroom experiential model was applied.

Findings
The results of the students’ activities indicated that most of the students were able to develop the twenty-first century skills needed to conduct the activities and avoid the tendency to follow directions from someone in authority. After the implementation of this study, the student teachers revealed higher-order thinking skills and were also able to develop learning materials and assessments that were appropriate to elementary school pupils. Still, the “old tendencies” (e.g. not thinking out of the box and waiting for direct instructions) sometimes emerged.

Research limitations/implications
The study was applied to a single course in one out of five parallel classes in a university in a particular area in Indonesia, a developing Asian country with a collectivist culture.

Originality/value
This paper exemplifies how learning and teaching activities in a higher education institution in a developing country can be designed to help future teachers prepare themselves to function and teach in a globalized society.
Comparison of plant–soil feedback experimental approaches for testing soil biotic interactions among ecosystems
Authors: Gundale Michael J. , Wardle David A. , Kardol Paul , Nilsson Marie‐Charlotte 
Published: August 2018

Summary

The study of interactions and feedbacks between plants and soils is a rapidly expanding research area, and a primary tool used in this field is to perform glasshouse experiments where soil biota are manipulated. Recently, there has been vigorous debate regarding the correctness of methods for carrying out these types of experiment, and specifically whether it is legitimate to mix soils from different sites or plots (mixed soil sampling, MSS) or not (independent soil sampling, ISS) to create either soil inoculum treatments or subjects.

We performed the first empirical comparison of MSS vs ISS approaches by comparing growth of two boreal tree species (Picea abies and Pinus sylvestris) in soils originating from 10 sites near the boreal forest limit in northern Sweden, and 10 sites in the subarctic region where boreal forests may potentially expand as a result of climate change.

We found no consistent differences in the conclusions that we reached whether we used MSS or ISS approaches.

We propose that researchers should not choose a soil handling method based on arguments that one method is inherently more correct than the other, but rather that method choice should be based on correct alignment with specific research questions and goals.
Naturaleza jurídica del seguro de vida grupo deudores
Authors: Tabares Cortés Felipe 
Published: August 2018

El seguro de vida grupo deudores protege la entidad bancaria asegurada contra el riesgo de pérdida que puede causar el deceso o incapacidad del deudor, asegurando entonces el reembolso de la deuda. En este esquema, el tomador es el banco que al mismo tiempo tiene la calidad de beneficiario. Esta particularidad del contrato de seguro vida grupo deudores dificulta el entendimiento que tradicionalmente se tiene de la noción de parte en el contrato
de seguro colectivo. Más aun, la interpretación que al respecto ha hecho la jurisprudencia no ha servido para aclarar el derecho que tienen los deudores respecto del asegurador o el banco en este tipo de contratos. Después de describir la interpretación de la Corte Suprema de Justicia de Colombia sobre las principales reglas del contrato de seguro de vida grupo y de su comparación con las de las cortes de Francia y de Singapur, el autor describe la nueva teoría del banco-tomador como un intermediario en la distribución del seguro de vida grupo deudores, buscando con ello simplificar los problemas que actualmente presenta este contrato en nuestro país.
Dried blood spot and mini-tube blood sample collection kits for postal HIV testing services: a comparative review of successes in a real-world setting
Authors: Page Matthew , Atabani Sowsan F , Wood Martyn , Smit Erasmus , Wilson Steven , Atherton Carol , Davenport Clare F , Hartland Daniel , Simpson Mark , Taylor Stephen 
Published: August 2018

Objectives
This is a comparative review between using dried blood spot (DBS) and mini-tube (MT) HIV sampling kits as part of an online sexually transmitted infection (STI) postal testing service. England has recently seen increases in internet-based and postal (eHealth) STI services. Expanding accessibility and testing for patients, cost implications and narrowing the HIV undiagnosed margin are drivers for this.

Methods

In 2017, data were reviewed from an online postal STI kit requesting service at a time of transitioning from MT to DBS. We compared the STI postal kit and HIV blood sample return rates, and the successful processing/analysis rates of the DBS and MT kits. Descriptive statistics were applied to participant characteristics, with Pearson’s χ
2
or Fisher exact test used to demonstrate statistical differences. We also describe and calculate a ‘request-to-result ratio’ (RRR) for both kit types. The RRR is defined as the number of online kit requests required to produce one successfully analysed result.

Results
550 STI postal kit requests from a North-West of England region were reviewed from 13 June 2017 to 22 September 2017 (275 MT, 275 DBS). Baseline characteristics between the two groups were comparable (63% woman, 90% white British and 86% heterosexual with a median age of 26 years). The successful processing rate for the DBS was 98.8% c.f. 55.7% for the MT (p<0.001). The RRR for MT was 2.96, c.f. 1.70 for DBS. There was a 5.4% false positive HIV rate in the MT c.f. none in the DBS.

Conclusions
This comparative analysis suggests that in this community setting, the use of postal HIV DBS kits resulted in a significantly improved RRR compared with MT. The biggest factor was the large number of MT samples not analysed due to inadequate blood volumes. The unexpected level of false positive results in the MT samples needs confirming in larger studies.
The structural, elastic and thermodynamic properties of intermetallic phases in Mg–Sn–Si–Ca(Sr) alloys: A first-principles study
Authors: Li Yan , Zhao Yuhong , Hou Hua , Yang Xiaomin 
Published: August 2018

The structural, elastic and thermodynamic properties of Mg2Si, Mg2Sn, CaMgSi and MgSnSr phases in Mg–Sn–Si–Ca(Sr) alloys have been investigated by implementing first-principles calculations. Formation enthalpies and cohesive energies show that MgSnSr has the strongest alloying ability and CaMgSi has the highest structural stability. The bulk modulus B, shear modulus G, Young’s modulus E, G/B, Poisson ratio [Formula: see text], anisotropy index A[Formula: see text] are estimated after evaluating the elastic constants. The mechanical properties are further analyzed and discussed. Finally, the Gibbs free energy and Debye temperature of these phases are calculated by means of the quasi-harmonic Debye model in temperature ranging from 0 K to 1000 K.
Elastic properties of the charge density wave system HoTe3
Authors: Saint-Paul M. , Guttin C. , Lejay P. , Leynaud O. , Monceau P. 
Published: August 2018

We present ultrasonic measurements on the rare earth tritelluride HoTe3 compound. Different anomalies are observed at the upper and lower charge density wave phase transition T[Formula: see text] = 284 K and T[Formula: see text] = 120 K. A striking T2 temperature dependence of the velocities of the longitudinal C[Formula: see text], C[Formula: see text] and shear C[Formula: see text] modes is observed in the ordered phase below the lower CDW phase transition T[Formula: see text]. Such a behavior is related to the temperature dependence of the CDW order parameter.
Life histories, demographies and population dynamics of three sympatric chameleon species (Furcifer spp.) from western Madagascar
Authors: Eckhardt Falk , Kraus Cornelia , Kappeler Peter M. 
Published: August 2018

Abstract
The life histories and population dynamics of chameleons remain poorly known, most likely due to practical challenges related to their cryptic nature. However, several studies have indicated that some of these reptiles have unusually brief life histories. Specifically, one Madagascan chameleon (Furcifer labordi) was found to have an annual life cycle characterized by population-wide survival of the austral winter in the egg stage; a unique life history among tetrapods. In this study, we compare the life history of F. labordi with two locally sympatric congeners (F. cf. nicosiai and F. oustaleti) in Kirindy forest, western Madagascar, to determine how these species adjust their life histories to a highly seasonal and unpredictable climate. We found differences in lifespan, timing of hatching, growth rates, survival, reproductive rates, adult body size, and roosting heights among all three species. Moreover, two species exhibited relatively short lifespans: 6-9 months in F. labordi and 16-18 months in F. cf. nicosiai. In contrast, F. oustaleti is perennial and large-sized juveniles and adults aestivate during the dry season, but survival rates of adults seemed relatively low. Strikingly, the annual cohort of F. labordi was already adult when hatchlings of F. oustaleti and subsequently F. cf. nicosiai emerged. Our study suggests the co-existence of three different life histories with seasonal adjustment that might be related to the partitioning of overall food availability and contributes valuable life history data on enigmatic chameleon species.
Emptiness and Presence in a Non-substantialist Formulation of Trinitarian Doctrine
Authors: Kang Chris 
Published: August 2018

AbstractThis paper examines the ideas of emptiness (śūnyatā) and presence (svabhāva) in the discourses of Indian Madhyamika thinkers in comparison with the work of prominent Kyoto School philosopher and key figure in Buddhist-Christian dialogue, Masao Abe (1915–2006). Madhyamika’s negative dialectic and Abe’s oeuvre are applied to the trinitarian theology of Scottish theologian and churchman Thomas Forsyth Torrance (1913–2007), even as Torrance’s oeuvre is allowed to recast and illuminate notions of emptiness in light of the trinitarian faith. In this movement of ideas, the dynamic interpretations and reinterpretations of the doctrine of emptiness by Indian thinkers are brought to bear on Abe’s thought and, in turn, on Torrance’s trinitarian theology. In this way, the metaphysical basis of trinitarian doctrine is drawn into sharper focus even as an emptiness-based, non-substantialist, onto-relational theology of the Trinity emerges as a potentially viable account of the nature of the triune Godhead.
Early Holocene Occupations at Ashash Rock Shelter (Zemmur, Western Sahara)
Authors: Borrell Ferran , Alcalde Gabriel , Clemente Ignacio , Saña Maria , Soler Joaquim , Soler Narcís 
Published: August 2018

AbstractThe archaeological record of the Western Sahara remains extremely fragmentary, with very few sites systematically excavated. The excavation at Ashash rock shelter (Zemmur region) has provided, for the first time in the region, the evidence of superimposition of two prehistoric occupations that have been radiocarbon dated to the early 9th millennium cal.BPand to the mid-7th millennium cal.BP. The Epipalaeolithic occupation is strongly marked by the standardised production of geometric microliths and points using a microburin blow technique. The Neolithic occupation of the site has yielded a few potsherds that provide the first unambiguous evidence of pottery in the Zemmur area in the mid-7th millennium cal.BP.
Thrombolytic therapy in acute MI: coronary care nurses' knowledge and practice
Authors: Shaaban Khalil Nahla , Sayed Ismaeel Manal , Sayed Ewees Amany 
Published: August 2018

Thrombolytic therapy is commonly used to treat patients with acute myocardial infarction, and it must be administered quickly to be effective. Coronary care nurses are often the first health professionals to evaluate patients with suspected myocardial infarction in emergency rooms, and there are several protocols for prompt appraisal and management. Aim: The current study aimed to evaluate coronary care nurses' knowledge and practice concerning the management of patients w acute myocardial infarction receiving thrombolytic therapy. Methods: A descriptive cross-sectional analysis design was used. All coronary care nurses (n=30) at a university hospital in Upper Egypt were recruited. A questionnaire on demographics, a knowledge questionnaire and an observational checklist were used to collect data. Results: The majority of nurses (86.7%) had unsatisfactory knowledge scores about thrombolytic therapy. In addition, most of them (90%) showed unsatisfactory practices regarding administering thrombolytic therapy. Conclusion: Coronary care nurses' knowledge and practice were inadequate. Recommendations: Educational programmes should be offered to improve nurses' knowledge and practice around the administration of thrombolytic therapy to patients with acute myocardial infarction. In addition, their practice during thrombolytic drug administration should be monitored.
Capillary Electrophoretic Analysis of Exhaled Breath Condensate in the Diagnosis of Gastroesophageal Reflux Disease
Authors: Kubáň Peter , Ďurč Pavol , Lačná Julia , Greguš Michal , Foret František , Dolina Jiří , Konečny Štefan , Doubková Martina , Kindlová Dagmar , Pokojová Eva , Skřičková Jana 
Published: August 2018

Abstract
In this work, capillary electrophoresis with contactless conductometric detection (CCD) was used for the analysis of the ionic content of exhaled breath condensate (EBC) to differentiate between healthy individuals and patients with gastroesophageal reflux disease (GERD). The exhaled breath condensate was collected using a miniature sample collection device and the content analyzed using a separation electrolyte composed of 20 mM 2-(N-morpholino)ethanesulfonic acid, 20 mM L-histidine, 2 mM 18-Crown-6 and 30 M cetyltrimethylammonium bromide. The separation of anions took less than 2.5 minutes, while the cations were separated in less than 1.5 minutes. The most significantly elevated ions in the group of patients suffering from gastroesophageal reflux disease were chloride, nitrate, propionate and butyrate. Although the number of subjects was too small to draw definite conclusions with regard to the discriminatory power of these ions, the pilot data are promising for EBC as a useful non-invasive alternative for other methods used in the diagnosis of gastroesophageal reflux disease