bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calibration of fish-eye lens and error estimation on fireball trajectories: application to the FRIPON network
Authors: Jeanne S. , Colas F. , Zanda B. , Birlan M. , Vaubaillon J. , Bouley S. , Vernazza P. , Jorda L. , Gattacceca J. , Rault J. L. , Carbognani A. , Gardiol D. , Lamy H. , Baratoux D. , Blanpain C. , Malgoyre A. , Lecubin J. , Marmo C. , Hewins P. 
Published: June 2019

Context. Fireball networks are developing over the whole planet, with the aim of recovering meteorites and at the same time determining their orbits. The ultimate goal of such networks is to identify the parent bodies of meteorite families to achieve this, orbit accuracy is critical. Yet, the determination of an orbit relies on a long and complex reduction process including: (1) astrometry, with heavy distortion for fish-eye lenses, (2) estimation of the external bias on the observation, (3) fit of the trajectory, (4) deceleration model, and (5) actual orbit computation.
Aims. Our goal is to compute accurate trajectories with an estimate of internal and external errors as realistic as possible, taking advantage of the dense observation network FRIPON (Fireball Recovery and InterPlanetary Observation Network), which comprises more than 100 cameras in France and Europe. In particular, we pay special attention to the distortion of images due to fish-eye lenses. In the present paper, we describe the analytical protocol that allows us to compute trajectories and their uncertainties.
Methods. We developed a general distortion model to be used on the FRIPON fish-eye cameras. Such a model needs to be accurate even at low elevation, as most fireball observations are performed low on the horizon. The radial distortion is modelled by a nine-degree odd polynomial, hence by five parameters. In addition, we used three parameters to describe the geometry of the camera and two for non-symmetrical distortion. Lastly, we used a new statistical method taking systematic errors into account, which allows us to compute realistic confidence intervals. We tested our method on a fireball that fell on 2017-08-94 UT 00:06.
Results. The accuracy of our astrometrical model for each camera is 2 arcmin (1σ), but the internal error on the fireball of 2017-08-94 UT 00:06 measurement is 0.7 arcmin (better than 1/10 pixel). We developed a method to estimate the external error considering that each station is independent and found it equal to 0.8 arcmin. Real residuals are coherent with our estimation of internal and external error for each camera, which confirms the internal consistency of our method. We discuss the advantages and disadvantages of this protocol.
Gravitational waves from bodies orbiting the Galactic center black hole and their detectability by LISA
Authors: Gourgoulhon E. , Le Tiec A. , Vincent F. H. , Warburton N. 
Published: June 2019

Aims.We present the first fully relativistic study of gravitational radiation from bodies in circular equatorial orbits around the massive black hole at the Galactic center, Sgr A* and we assess the detectability of various kinds of objects by the gravitational wave detector LISA.Methods.Our computations are based on the theory of perturbations of the Kerr spacetime and take into account the Roche limit induced by tidal forces in the Kerr metric. The signal-to-noise ratio in the LISA detector, as well as the time spent in LISA band, are evaluated. We have implemented all the computational tools in an open-source SageMath package, within the Black Hole Perturbation Toolkit framework.Results.We find that white dwarfs, neutrons stars, stellar black holes, primordial black holes of mass larger than 10−4 M⊙, main-sequence stars of mass lower than ∼2.5 M⊙, and brown dwarfs orbiting Sgr A* are all detectable in one year of LISA data with a signal-to-noise ratio above 10 for at least 105years in the slow inspiral towards either the innermost stable circular orbit (compact objects) or the Roche limit (main-sequence stars and brown dwarfs). The longest times in-band, of the order of 106years, are achieved for primordial black holes of mass ∼10−3 M⊙down to 10−5 M⊙, depending on the spin of Sgr A*, as well as for brown dwarfs, just followed by white dwarfs and low mass main-sequence stars. The long time in-band of these objects makes Sgr A* a valuable target for LISA. We also consider bodies on close circular orbits around the massive black hole in the nucleus of the nearby galaxy M 32 and find that, among them, compact objects and brown dwarfs stay for 103–104years in LISA band with a one-year signal-to-noise ratio above ten.
Role of Renin-Angiotensin-System in Human Breast Cancer Cells: Is There a Difference in Regulation of Angiogenesis between Hormone-Receptor Positive and Negative Breast Cancer Cells?
Authors: Herr Daniel , Sauer Christof , Holzheu Iris , Sauter Regina , Janni Wolfgang , Wöckel Achim , Wulff Christine 
Published: June 2019

Abstract
Objective This study examined the role of the RAS in human breast cancer cells to question if there are differences between HR-positive and HR-negative cells with regard to regulation of VEGF.
Methods Expression of different RAS components in hormone receptor (HR)-positive and HR-negative breast cancer cells was investigated using RT-PCR. Different stimulation protocols with different RAS inhibitors were used to investigate the effect on VEGF expression. Angiotensin II-dependent expression of VEGF was quantified by real time PCR. In addition, the effect of intrinsic RAS was studied performing siRNA knockdown of angiotensinogen (AGT). Statistical analysis were calculated using IBM SPSS Statistics Version 21.
Results Expression of AT1R, AT2R, AGT and ACE was shown in HR-positive and HR-negative breast cancer cell lines. Extrinsic stimulation with angiotensin II increased VEGF significantly. After treatment with captopril or AT1R-inhibitor candesartan, VEGF-expression decreased significantly in HR-positive and HR-negative cell lines. However, inhibition of AT2R using PD 123,319 did not show any significant changes of VEGF. After prevention of intrinsic angiotensin II, extrinsic angiotensin II as well as the combination with inhibitors of the receptors caused a significant reduction of VEGF. Surprisingly, the overall effect of the RAS after knockdown of AGT revealed a significant increase of VEGF in HR-positive cells at any time while a significant decrease was observed in HR-negative cells after 144 hours incubation.
Conclusion The RAS-dependent regulation of VEGF between HR-positive and HR-negative breast cancer cells seems do be different. These findings provide evidence for a possible future therapeutic strategy.
Unterschiede in der Wirksamkeit von Kurzpausenaktivitäten im Vergleich von Bewegungspausen zu psychoregulativen Pausen bei kognitiver Belastung
Authors: Gollner Erwin , Savli Markus , Schnabel Florian , Braun Carmen , Blasche Gerhard 
Published: June 2019

ZusammenfassungDie Bedeutung einer bewussten Pausengestaltung und die Auswirkung auf die psychophysische Leistungsfähigkeit im Kontext der modernen Arbeitswelt ist noch wenig erforscht. Ermüdung durch geistige oder körperliche Tätigkeit kann als körperliches Warnsignal aufgefasst werden, um organischer Fehlbeanspruchung vorzubeugen. Um Ermüdung zu reduzieren, kommt der aktiven Pausengestaltung eine große Bedeutung zu. In der vorliegenden Studie wurden Studierende einer kognitiven Belastung (Vortrag) ausgesetzt – die durch 4 angeleitete Pausen (2 psychoregulative Pausen, 2 Bewegungspausen) in einem experimentellen Design unterbrochen wurde. Als Kontrollbedingung diente keine Pause. Die Ergebnisse der Studie zeigen die signifikant höhere Wirkung von Bewegungspausen im Vergleich zu psychoregulativen Pausen und keiner Pause bei kognitiven Belastungen. Zudem sind die angeleiteten Bewegungspausen signifikant „beliebter“ als die psychoregulativen Pausen. Die Ergebnisse weisen auf die steigende Bedeutung einer aktiven Pausengestaltung im Hochschulsetting bzw. Arbeitsumfeld zur Steigerung der Konzentrationsfähigkeit hin.
Ectopia Cordis: Two Different Cases with Literature Review
Authors: Sahu Manoj Kumar , Yadav Mayank , Arora Yatin , Singh Sarveshpal , Devagourou Velayoudam , Chaudhary Shiv Kumar 
Published: June 2019

AbstractEctopia cordis is a rare congenital anomaly with thoracic exteriorization of the heart. With few exceptions, it is universally fatal. Surgical correction is the only final treatment option for this defect but with a very high mortality. The authors present two cases of ectopia cordis, both were operated upon in urgent basis, and one baby survived.
Malrotation in Congenital Diaphragmatic Hernia: Is It Really a Problem?
Authors: de Blaauw Ivo , van Ling Julia , Botden Sanne M. B. I. , Heiwegen Kim 
Published: June 2019

Abstract
Introduction Congenital diaphragmatic hernia (CDH) has been associated with other congenital malformations, such as intestinal rotation abnormalities. However, there is no standard evaluation and treatment of intestinal rotation during initial CDH repair. This study evaluates intestinal malrotation in CDH patients.
Materials and Methods All patients with a CDH treated in a high-volume center between 2000 and 2015 were retrospectively evaluated. Demographics, gastrointestinal characteristics, surgical treatment, and abdominal outcomes (acute surgery, small bowel obstruction, and volvulus) were described.
Results A total of 197 CDH patients were surgically repaired. In 76 (39%) patients, a malrotation was described at initial CDH repair, in 39 (20%) patients, a normal rotation, but 82 patients (42%) had no report on intestinal rotation. During follow-up (range: 2–16 years), 12 additional malrotations were diagnosed, leading to a prevalence of at least 45% (n = 88). These were mostly diagnosed due to acute small bowel obstruction, of which three had a volvulus. Of the 12 later diagnosed malrotations, 58% required acute surgery, compared to 3% of the 76 initially diagnosed patients (p < 0.001).
Conclusion Malrotation is associated with CDH, with a prevalence of at least 45% and in 21% a normal intestinal rotation. “Missed” malrotations have a higher risk on need for acute surgery later in life.
Vascular Nanomedicine: Current Status, Opportunities, and Challenges
Authors: Sun Michael , Sen Gupta Anirban 
Published: June 2019

AbstractThe term “nanotechnology” was coined by Norio Taniguchi in the 1970s to describe the manipulation of materials at the nano (10−9) scale, and the term “nanomedicine” was put forward by Eric Drexler and Robert Freitas Jr. in the 1990s to signify the application of nanotechnology in medicine. Nanomedicine encompasses a variety of systems including nanoparticles, nanofibers, surface nano-patterning, nanoporous matrices, and nanoscale coatings. Of these, nanoparticle-based applications in drug formulations and delivery have emerged as the most utilized nanomedicine system. This review aims to present a comprehensive assessment of nanomedicine approaches in vascular diseases, emphasizing particle designs, therapeutic effects, and current state-of-the-art. The expected advantages of utilizing nanoparticles for drug delivery stem from the particle's ability to (1) protect the drug from plasma-induced deactivation; (2) optimize drug pharmacokinetics and biodistribution; (3) enhance drug delivery to the disease site via passive and active mechanisms; (4) modulate drug release mechanisms via diffusion, degradation, and other unique stimuli-triggered processes; and (5) biodegrade or get eliminated safely from the body. Several nanoparticle systems encapsulating a variety of payloads have shown these advantages in vascular drug delivery applications in preclinical evaluation. At the same time, new challenges have emerged regarding discrepancy between expected and actual fate of nanoparticles in vivo, manufacturing barriers of complex nanoparticle designs, and issues of toxicity and immune response, which have limited successful clinical translation of vascular nanomedicine systems. In this context, this review will discuss challenges and opportunities to advance the field of vascular nanomedicine.
Investigation of Recurrent Cases of Head and Neck Cancer after Initial Treatment
Authors: Kitoh Ryosuke , Mori Kentaro , Usami Shin-ichi 
Published: June 2019

AbstractThe optimal follow-up strategy for patients with head and neck cancer after primary treatment is still under debate. This study aimed to review the data of patients with recurrence and evaluate our follow-up strategy. Patients with head and neck cancer who underwent surgery or chemoradiotherapy as the primary treatment between 2012 and 2016 were enrolled. All the patients were carefully followed up at our institution via intensive clinical examination and routine computed tomography (CT) and positron emission tomography (PET)/CT. Recurrence was detected in 20 of the patients treated by surgery and 25 of 96 patients treated by chemoradiotherapy. In more than 90% of the patients, recurrence occurred within 2 years of the primary treatment. Among the patients with recurrence, 11 showed local recurrence, 17 showed regional recurrence, and 17 others showed distant metastasis. In almost all patients with distant metastases, recurrence was detected using CT or PET/CT, whereas among the patients with local or regional recurrence, recurrence was detected based on the patients' complaints and their clinical examination results. Only salvage surgery was observed to be associated with disease-free survival after recurrence. Thus, analysis of the recurrence patterns and appropriate surveillance can result in improved salvage treatment for patients with recurrence.
甘青方言格標記「哈」的來源
Authors: Zhou Chenlei 
Published: June 2019

抽象
本文探討甘青方言格標記「哈」的來源。首先梳理學界的兩種主要觀點，即頓詞說和方位詞說，進而提出本文的假設：「哈」本字是漢語的「下」，在和藏語的接觸中，首先用如與格標記並標記部分「賓語」，進而擴展到整個賓語，成為賓格標記，從而形成共時層面不見於藏語和阿爾泰語的與格-賓格同形的狀態。在共時的甘青方言的格系統中，「哈」是早期和藏語接觸的產物，離格標記、部分方言的工具格標記和反身領屬標記等是後期和阿爾泰語接觸的產物。
論漢語數詞-動量詞組合的成分完整性
Authors: He Chuansheng , Tan Dandan 
Published: June 2019

抽象傳統語言學界對漢語動量詞的研究儘管在細節方面有不同的分析方法，但是都認為數詞和動量詞構成一個句法整體，在具體結構中作狀語、賓語等。生成語言學者大部分也是把數詞和動量詞構成一個句法整體，也有生成語言學者不把數詞和動量詞構成一個句法整體，而是投射層級結構。本文評論Zhang (2017)的層級句法分析，首先指出Zhang提出的事實概括並非只支持層級分析，然後論證Zhang提出的兩個佐證也不支持動量詞的層級分析，甚至得出相反的結論，最後提出動量詞層級分析會導致多個難以解釋的句法語義方面的困難。
Newly recognised languages in Chamdo
Authors: Nyima Tashi , Suzuki Hiroyuki 
Published: June 2019

Abstract
This article presents information regarding newly recognised
non-Tibetic Tibeto-Burman languages spoken in three counties, Dzogang, Markham,
and Drag-yab, of Chamdo Municipality and the adjacent Dzayul County in the Tibet
Autonomous Region. First, we introduce four languages – Lamo, Larong sMar,
Drag-yab sMar, and gSerkhu – identifying the location of each language on the
Chinese administrative map as well as the numbers of speakers of the languages.
Second, we provide a brief historical background on these languages, which
suggests a relationship between them and Qiangic groups. Third, we display
lexical evidence that shows not only their non-Tibetic features but also their
closeness to Qiangic languages. Finally, the article focuses on Lamo, an endangered language spoken in
Dzogang County, and provides a linguistic analysis of an annotated Lamo
historical narrative in the Appendix.
Making health care responsive to the needs of older people
Authors: Bridges Jackie , Pope Catherine , Braithwaite Jeffrey 
Published: June 2019

Abstract
This commentary highlights the importance of health system responsiveness to older people living with complex health needs. Age-related changes and associated morbidity can present barriers to identifying an individual’s health needs, expectations, values and preferences, and so sufficient time, skill and resource is required to inform the development of a tailored plan for each individual. A focus on responsiveness moves thinking beyond the responsibilities of the individual clinician in the single encounter, and allows us to identify elements of the wider system that may constrain how well the clinician is able to respond. Setting the goal of responsive health care requires us to assess the suitability of wider health system features and processes for meeting the diverse needs of individual people throughout their journey, and the extent to which the system can adapt dynamically as needs change. Standardised approaches to care prescribed across organisations (such as time-based targets or routinised approaches to inpatient nursing care) are likely to result in low responsiveness as individual complexity grows, disadvantaging patients with needs that do not fit the prescribed approach. Responsiveness is high when individual practitioners and clinical teams have the resources, decentralised authority, flexibility and autonomy to provide the care required. Building a more responsive health system requires a greater understanding of how these conditions can be achieved.
National trends in prescription drug expenditures and projections for 2019
Authors: Schumock Glen T , Stubbings JoAnn , Hoffman James M , Wiest Michelle D , Suda Katie J , Rim Matthew H , Tadrous Mina , Tichy Eric M , Cuellar Sandra , Clark John S , Matusiak Linda M , Hunkler Robert J , Vermeulen Lee C 
Published: June 2019

AbstractPurposeHistorical trends and factors likely to influence future pharmaceutical expenditures are discussed, and projections are made for drug spending in 2019 in nonfederal hospitals, clinics, and overall (all sectors).MethodsDrug expenditure data through calendar year 2018 were obtained from the IQVIA National Sales Perspectives database and analyzed. New drug approvals, patent expirations, and other factors that may influence drug spending in hospitals and clinics in 2019 were also reviewed. Expenditure projections for 2019 for nonfederal hospitals, clinics, and overall (all sectors) were made through a combination of quantitative analyses and expert opinion.ResultsU.S. prescription sales in calendar year 2018 totaled $476.2 billion, a 5.5% increase from 2017 spending. The top 3 drugs by expenditures were adalimumab ($19.1 billion), insulin glargine ($9.3 billion), and etanercept ($8.0 billion). Prescription expenditures in nonfederal hospitals totaled $35.8 billion, a 4.8% increase from 2017. Expenditures in clinics in 2018 increased by 13.0% to $80.5 billion. The increase in spending in nonfederal hospitals was largely driven by new products and increased utilization of existing products. The list of the top 25 drugs by expenditures in nonfederal hospitals and clinics was dominated by specialty drugs.ConclusionWe predict continued moderate growth of 4–6% in overall drug expenditures (across the entire U.S. market). We expect the clinic sector to continue to experience high (11–13%) growth in drug spending in 2019. Finally, for nonfederal hospitals we anticipate growth in the range of 3–5%. These estimates are at the national level. Health-system pharmacy leaders should carefully examine local drug utilization patterns to determine their own organization’s anticipated spending in 2019.
Deep learning on chaos game representation for proteins
Authors: Löchel Hannah F , Eger Dominic , Sperlea Theodor , Heider Dominik 
Published: June 2019

Abstract

Motivation
Classification of protein sequences is one big task in bioinformatics and has many applications. Different machine learning methods exist and are applied on these problems, such as support vector machines (SVM), random forests (RF) and neural networks (NN). All of these methods have in common that protein sequences have to be made machine-readable and comparable in the first step, for which different encodings exist. These encodings are typically based on physical or chemical properties of the sequence. However, due to the outstanding performance of deep neural networks (DNN) on image recognition, we used frequency matrix chaos game representation (FCGR) for encoding of protein sequences into images. In this study, we compare the performance of SVMs, RFs and DNNs, trained on FCGR encoded protein sequences. While the original chaos game representation (CGR) has been used mainly for genome sequence encoding and classification, we modified it to work also for protein sequences, resulting in n-flakes representation, an image with several icosagons.

Results
We could show that all applied machine learning techniques (RF, SVM and DNN) show promising results compared to the state-of-the-art methods on our benchmark datasets, with DNNs outperforming the other methods and that FCGR is a promising new encoding method for protein sequences.

Availability and implementation
https://cran.r-project.org/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Differentially expressed lncRNA-m433s1 regulates FSH secretion by functioning as a miRNA sponge in male rat anterior pituitary cells†
Authors: Han Dong-Xu , Sun Xu-Lei , Wang Chang-Jiang , Yu Ze-Wen , Zheng Yi , Huang Yi-Jie , Wang Wen-Hua , Jiang Hao , Gao Yan , Yuan Bao , Zhang Jia-Bao 
Published: June 2019

AbstractLong noncoding RNAs (lncRNAs) are important regulators that have multiple functions in a variety of biological processes. However, the contributions of lncRNAs to follicle-stimulating hormone (FSH) secretion remain largely unknown. In this study, we first identified a novel lncRNA, lncRNA-m433s1, as an intergenic lncRNA located in the cytoplasm. We next used MS2-RIP assays to demonstrate that lncRNA-m433s1 interacted with miR-433. Furthermore, we detected the levels of lncRNA-m433s1, miR-433, and Fshβ expression, FSH concentrations, and apoptosis upon overexpression and knockdown of lncRNA-m433s1, revealing that lncRNA-m433s1 upregulated Fshβ expression. Globally, lncRNA-m433s1 reduced the inhibitory effect of miR-433 on Fshβ and further regulated FSH secretion as a competing endogenous RNA (ceRNA) by sponging miR-433. This ceRNA model will provide novel insight into the regulatory mechanisms of lncRNAs associated with rat reproduction.
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†
Authors: Lu Yonggang , Oura Seiya , Matsumura Takafumi , Oji Asami , Sakurai Nobuyuki , Fujihara Yoshitaka , Shimada Keisuke , Miyata Haruhiko , Tobita Tomohiro , Noda Taichi , Castaneda Julio M , Kiyozumi Daiji , Zhang Qian , Larasati Tamara , Young Samantha A M , Kodani Mayo , Huddleston Caitlin A , Robertson Matthew J , Coarfa Cristian , Isotani Ayako , Aitken R John , Okabe Masaru , Matzuk Martin M , Garcia Thomas X , Ikawa Masahito 
Published: June 2019

AbstractMore than 1000 genes are predicted to be predominantly expressed in mouse testis, yet many of them remain unstudied in terms of their roles in spermatogenesis and sperm function and their essentiality in male reproduction. Since individually indispensable factors can provide important implications for the diagnosis of genetically related idiopathic male infertility and may serve as candidate targets for the development of nonhormonal male contraceptives, our laboratories continuously analyze the functions of testis-enriched genes in vivo by generating knockout mouse lines using the CRISPR/Cas9 system. The dispensability of genes in male reproduction is easily determined by examining the fecundity of knockout males. During our large-scale screening of essential factors, we knocked out 30 genes that have a strong bias of expression in the testis and are mostly conserved in mammalian species including human. Fertility tests reveal that the mutant males exhibited normal fecundity, suggesting these genes are individually dispensable for male reproduction. Since such functionally redundant genes are of diminished biological and clinical significance, we believe that it is crucial to disseminate this list of genes, along with their phenotypic information, to the scientific community to avoid unnecessary expenditure of time and research funds and duplication of efforts by other laboratories.