bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muistisairaan ihmisen mielen hyvinvoinnin edellytykset - miten turvata oikeus niiden toteutumiseen?
Authors: Heimonen Sirkkaliisa , Mäki-Petäjä-Leinonen Anna 
Published: March 2018

Muistisairaus vaikuttaa sitä sairastavan ihmisen ja hänen läheistensä hyvinvointiin ja elämänlaatuun. Kognitiivisten kykyjen heikentyminen ja sosiaalisissa suhteissa tapahtuvat muutokset aiheuttavat haavoittuvuutta. Yksilöllisen tuen, laadukkaiden palvelujen ja hyvän hoivan perustana on haavoittuvuuden ymmärtäminen ja kohtaaminen. Muistisairautta sairastavan ihmisen mielen hyvinvoinnin vahvistamisen tulee olla tavoitteena tuen, palvelujen ja hoivan käytännöissä. Ammattihenkilöstöllä on keskeinen rooli mielen hyvinvoinnin edellytysten tunnistamisessa sekä niiden toteutumisessa. Tarkastelemme tässä artikkelissa muistisairaan ihmisen mielen hyvinvointia ja sen edellytysten turvaamista psykologisesta, eettisestä ja oikeudellisesta näkökulmasta. Nostamme esiin neuvonnan ja ohjauksen keskeisenä tukimuotona ja kuntoutukseen kuuluvana keinona ja pohdimme sen keskeistä merkitystä muistisairaan ihmisen mielen hyvinvoinnin vahvistamisessa.
The preconditions of psychological wellbeing in persons with dementia - How to secure the right of their implementation?
Memory illnesses affect the wellbeing and quality of life of the afflicted persons and their significant others. The deterioration of cognitive capacities and changes in social relationships are a cause for vulnerability. Understanding and encountering vulnerability form the basis of individual support and high quality services and care. The promotion of the psychological wellbeing of persons with dementia should be the focus in the practice of care, support and services. The professionals have a key role in the recognition and implementation of the preconditions of psychological wellbeing. In this article we investigate the psychological wellbeing of persons with dementia from psychological, ethical and judicial perspectives. We present guidance and counselling as key means of support and rehabilitation. We also observe the significance of counselling for the promotion of psychological wellbeing of persons with dementia.
Penggunaan Model Pembelajaran Eklektik dalam Meningkatkan Prestasi Belajar Bahasa Indonesia dengan Kovarian Kognisi di Sekolah Inklusif
Authors: -- Gunarhadi 
Published: March 2018

This research aims to know the impact of eclectic teaching model, measure the extent of eclectic teaching model on the learning achievement, and measure the role of cognition in facilitating the learning achievement of Bahasa Indonesia. This research was conducted to a group of students in 75 inclusive elementary schools in Boyolali assigned in cluster random sampling. Quasi experiment was applied for 68 sixth graders representing both experiment and control groups. The data was analyzed by means of ANCOVA as to compare the learning achievement before and after treatment, between bothÂ experiment and control groups as controlled by cognition. The research come to conclusion that: eclectic teaching model gave significant impact of the student learning achievement, eclecti teaching model was more effective than conventional teaching method, the cognition turned to take role to the improvement of the student learning achievement.Â ABSTRAKTujuan penelitian ini adalah untuk mengetahui ada tidaknya dampak model pembelajaran Eklektik terhadap prestasi belajar, mengetahui seberapa besar dampak model pembelajaran Eklektik terhadap prestasi belajar, dan mengetahui peran kognisi dalam mempengaruhi perubahan hasil belajar siswa. Penelitian dilaksanakan terhadap sampel yang diambil secara acak melalui cluster random sampling dari sejumlah 75 Sekolah Dasar penyelenggara pendidikan inklusi di Kabupaten Boyolali. Metode penelitian ini adalah experimen tidak penuh (quasi experiment) dengan menggunakan 68 siswa kelas VI SD yang dibagi menjadi kelompok eksperimen dan kelompok kontrol. Data peneltian dianalisis melalui ANAKOVA dengan cara membandingkan hasil belajar sebelum dan setelah perlakuan dan membandingkan hasil belajar kelompok eksperimen dan kelompok ontrol dengan mempertimbangkan pengaruh kognisi. Hasil penelitian menyimpulkan bahwa: model pembelajaran eklektik memberikan pengaruh signifikan pada prestasi belajar siswa, model pembelajaran eklektik lebih effektif dibanding dengan metode tradisional, peningkatan hasil belajar siswa juga dipengaruhi oleh kemampuan kognisi siswa.
Model Pembelajaran Berbasis Komik Untuk Mencapai Ranah Afektif Pada Pendidikan Kewarganegaraan Bagi Anak Berkesulitan Belajar
Authors: Wahyudi Ari 
Published: March 2018

The research target was to create a learning innovation through comic package in the form of civilization education which was packed by simply story and interesting picture from the daily life of children. By using developing research and collecting data technique such as observation, interview, and test it was resulted as the following: a) the first year resulted prototype learning base-comic to civilization education, and b) the second year resulted effectiveness test of attaining affective domain in learning civilization education by applying learning model base-comic for difficulty learning children who was very significant in Sidoarjo District, Mojokerto District and Surabaya city. The end of this result is comic book for third, the fourth, and fifth classes which had got ISBN.Â ABSTRAKTarget peneliti ini adalah menciptakan terobosan belajar melalui paket komik berupa materi Pendidikan Kewarganegaraan yang dikemas dengan cerita sederhana dan gambar yang menarik dari kondisi kehidupan nyata sehari-hari anak. Dengan desain penelitian pengembangan dan teknik pengumpulan data observasi, wawancara, dan tes dihasilkan penelitian sebagai berikut: a) tahun pertama menghasilkan prototipe pembelajaran berbasis komik pada pendidikan kewarganegaraan, dan b) tahun kedua menghasilkan uji efektivitas pencapaian ranah afektif dalam pembelajaran pendidikan kewarganegaraan dengan penerapan model pembelajaran berbasis komik pada anak berkesulitan belajar yang sangat signifikan di kabupaten Sidoarjo, kabupaten Mojokerto dan kota Surabaya. Hasil akhir penelitian ini adalah buku komik belajar untuk kelas 3, kelas 4 dan kelas 5 yang telah mendapatkan pengesahan berupa ISBN.
Letter from the Editor
Authors: Colledge Thomas 
Published: March 2018

The editors of the International Journal for Service Learning in Engineering, Humanitarian Engineering and Social Entrepreneurship (IJSLE) are pleased to publish this, our first special edition of the Journal, entitled “Opportunities and Barriers to Integrating Service Learning into Engineering Education”. The editors solicited scholarly manuscripts that would explore three areas related to service learning in engineering, humanitarian engineering, and/or social entrepreneurship - both domestically and internationally. These three areas included: 1. Assessment of Service Learning in Engineering 2. Scholarship of Service Learning in Engineering 3. Interdisciplinary Engagement
Engineering and Engaged Scholarship at Penn State Part II: The Existing Ecosystem
Authors: Colledge Thomas H 
Published: March 2018

The objective of engineering education is to educate students who are ‘ready to engineer’. This implies that students should be broadly prepared with not only deep knowledge and understanding of the technical fundamentals, but also the pre-professional skills required to be successful in the engineering workplace of today and tomorrow1. Part I of this paper includes a brief rationale and need for ‘Engaged Scholarship’ and the inherent need for a robust ecosystem to support it. Part II details the existing curricular, co-curricular, and extra-curricular efforts which form the core for the engaged scholarship ecosystem in the College of Engineering at the Pennsylvania State University. Curricular, co-curricular and extra-curricular opportunities for students are detailed. Part III provides an overview of how this assortment of minors, certificates, programs, courses, and student organizations is being integrated and institutionalized into a strategic mission for the University.
Assessment of Colloidal Silver Impregnated Ceramic Bricks For Small-Scale Drinking Water Treatment Applications
Authors: Nover Daniel M , McKenzie Erica R , Joshi Geetika , Fleenor William E 
Published: March 2018

Colloidal silver treated ceramic substrates were tested for effectiveness in small-scale, point-of-use (POU) drinking water treatment. Coated substrates were used to treat harvested rainwater to test their ability to produce safe drinking water, where safety was evaluated based on both coliform and silver concentrations. The effect of two different residence times was also evaluated. Although the harvested rainwater had high concentrations of coliforms (>200 CFU/100 mL), no fecal coliforms were detected. Upon initial deployment, coliform-free water was produced immediately, although silver concentrations exceeded WHO guidelines. The treatment also produced coliform-free water within 24 hours following addition of a solution of canine feces (leading to an initial spike in coliform and E. coli concentrations) to the tanks. Silver concentration in the treatment tanks generally increased when the tanks were left to stand without water cycling and was noticeably reduced when large volumes were cycled. Over 60 days, silver concentration in tanks with different residence time stayed relatively constant at about 60 ppb. From days 60 to 76 concentrations in the short residence time tank (residence time = 1.7 days) decreased dramatically. Results suggest that colloidal silver coated substrates may be a feasible approach to small scale water treatment systems but that ensuring safe drinking water requires careful attention to sizing substrates, cistern residence time, and duration of treatment effectiveness.
A study on the prescription pattern of anti-hypertensive drugs in general hospital of Al-Quwayyah, Saudi Arabia
Authors: Al-Otaibi Faisal 
Published: March 2018

An open, non-comparative, observational study conducted on hypertensive patients attending the OPD medicine of Al-Quwayyah general hospital, Al-Quwayyah, Saudi Arabia by conducting patient interviews and recording the data on drug utilization form based on JNC-7 and WHO format. Total of 212 hypertensive patients were included in study, prevalence of hypertension was found to be higher in male in age group of 45-59 years, smoker and pre-hypertension stage. 60.38% antihypertensive drugs prescribed by trade name and by 39.62 % by generic name. It was observed that Monotherapy were most prescribed mode of drugs and in Combination therapy the frequency and percentage of two drug combination were found 3/4 of the total combination therapy similarly three combination drugs were 16.72 % and more than three drugs combination were only 3.41 %. It was observed that Beta blocker were prescribed most (28.77%) among antihypertensive drugs followed by calcium channel blocker (25.47%), ACE inhibitor (17.92%), Diuretics (12.74%), AT II Receptor Blocker (9.4%) and alpha blocker were found to be least one. The Conclusion of study was found that the Utilization pattern of Antihypertensive drug in General hospital Al-Quwayyah, Saudi Arabia indicates that Beta blocker were prescribed individually most as monotherapy and if combination therapy then 2 drug combination of antihypertensive drugs.
Keywords: Prescription; Antihypertensive drugs; Beta Blocker
Quantitative Structure-Activity Relationship Study of Curcumin Analogues as Anti-proliferative Agents of Human Prostate Cancer Cell Line (PC-3)
Authors: Reyes Andrea Marie M. , Billones Junie B. 
Published: March 2018

A quantitative structure-activity relationship (QSAR) study has been performed on curcumin analogues in order to establish the effect of variation of structural, electronic and topological properties on the anti-proliferative activity against prostate cancer cell line PC-3. The structure-based properties were calculated by the use of Hyperchem® and Dragon® softwares and the multi-linear regression equations were generated by the use of SPSS® software. Six models of PC-3 activity have been developed according to the types of QSAR descriptors. All models were cross-validated using leave-one-out (LOO) method. The models indicate that a more potent curcumin derivative against PC-3 should have smaller surface area, greater volume, lower polarizability, and fewer oxygen and multiple bonds.
Partial Characterization of Glycans from Daedalea quercina (L) Fr.
Authors: Clerigo Melody M. , Yang Wen Bin , Paano Anamy Ma C. 
Published: March 2018

Heteroglycans were extracted and isolated from the fruiting bodies of wild mushroom Daedalea quercina (L) Fr. These were obtained from sequential extraction with hot water, 1% Ammonium oxalate then 5% Sodium hydroxide solution followed by ethanol or acidic precipitation affording crude extracts which were further purified by dialysis membrane (MWCO 12 400). Separation by charge and size were done using DEAE-cellulose column and Sephadex G-100 or Sepharose CL-4B. This resulted to water soluble neutral (W1P-1A) and acidic (W1P-2A) glycan isolates, ammonium oxalate soluble (A1P-1) and two alkali soluble (N1P-1 and N1P-2) glycan isolates. Characterization of the hydrolyzed isolates using HPAEC-PAD and MALDI TOF MS showed glucan-rich heteroglycans (W1P-1A and W1P-2A); glucan and mannan rich heteroglycan, (N1P-1) and galactan-rich heteroglycan (A1P-1). The latter being the first reported galactan-rich glycan found in ammonium oxalate mushroom extract. The hydrolysates had approximately 4-5 degree of polymerization with molecular weights ranging from 689.680 to 851.788 Da. The hydrolysate of isolate N1P-2 is a glucan-rich heteroglycan which also contain N-acetyl glucosamine units. It is composed of polymers with 4-5 hexose units as well as N-acetyl glucosamine containing polymers of 6-8 hexose units with molecular weight range of 689.799 to 851.915 Da and 1055.718 to 1379.584 Da, respectively.
New Poly(Hydroxylauric-co-Lactic Acid) Liquid Polymer for Dissolving Lipophilic Drugs
Authors: Sumera Florentino C. , Pontillas Shienna Marie A. , Bilo Josanelle Angela V. , Mateo John Marty 
Published: March 2018

A liquid, biocompatible polyester based polymer, which could facilitate injectable formulations by simple mixing with the active substance (drug) is much needed by the pharmaceutical companies. A favourite candidate is polylactic acid (PLA) which is biocompatible and biodegradable. However PLA is solid with high crystallinity. Thus, in this research, hydroxylauric acid (HOLA) was copolymerized with lactic acid (LA) in different ratios by polycondensation technique at 180 °C, without a metal catalyst and avoiding the formation of interfering lactides, to provide a liquid polyester. The copolymers molecular weights were determined by Gel Permeation Chromatography (GPC) and their physical states indicated as solid or liquid were noted. The structures as polyesters were confirmed by FT-IR and 1H NMR spectroscopy. Poly(HOLA:LA) products from reactant ratios 0:100 is solid, while ratios of 20:80, 40:60 are mixed (paste) and 60:40, 80:20 and 100:0 are liquids. Thus, the liquid polyesters from the polycondensation of HOLA and LA without catalyst were picked as potential candidates for dissolving hydrophobic drugs that could be used as injectables in controlled drug delivery experiments.
Novel Chitosan Microparticles for Sequestration of Overdosed Drug
Authors: Chakraborty Soma , Agbayani Patricia Teresa F. , Chua Modesto T. 
Published: March 2018

Chitosan microparticles were synthesized by crosslinking chitosan and glycidyl trimethylammonium chloride modified chitosan inside the reverse micelles of Span and Tween 80. The particles were of uniform size with the average diameter of 10 μm. The particles swelled almost twice the original size in 20 min when dispersed in a buffer solution of pH 7.4. The feasibility of chitosan microparticles as drug sequestrant was tested using propafenone as the model drug. The particles sequestered free propafenone from a buffer solution of pH 7.4. In 20 min unmodified chitosan and modified chitosan microparticles sequestered 53% and 51.5% of the free drug respectively. The amount of drug sequestered increased with increase in the initial free drug concentration. The presence of normal saline also improved propafenone sequestration.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW DENGAN MEDIA VCD UNTUK MENINGKATKAN HASIL BELAJAR FISIKA
Authors: Susanti Novi 
Published: March 2018

Dalam proses belajar mengajar guru mempunyai tugas untuk memilih model pembelajaran berikut media yang tepat sesuai dengan materi yang disampaikan demi tercapainya tujuan pembelajaran. Dalamproses belajar mengajar di kelas terdapat keterkaitan yang amat erat antara guru, siswa, dan sarana. Penelitian tindakan kelas ini dilakukan dalam dua siklus dengan subyek penelitian siswa kelas XII IPA. 2 SMA Negeri 1 Pinggir semester 1 tahun pelajaran 2013/2014. Data keaktifan siswa dikumpulkan dengan pedoman observasi dan data tentang hasil belajar dikumpulkan dengan tes hasil belajar. Pelaksanaan tindakan diawali dengan membagi kelas atas 6 kelompok, menyampaikan tujuan pembelajaran, menyampaikan materi pembelajaran dengan media VCD,kerja kelompok dalam menyelesaikan soal, presentase kelompok dan tes. Hasilpenelitian menunjukkan Penerapan Model Pembelajaran Kooperatif Tipe Jigsaw melalui Media VCD sebagai media pembelajaran listrik statis dapat meningkatkan keaktifan siswa dan dapat meningkatkan hasil belajar siswa dari rata-rata 69,58 dengan ketuntasan klasikal 71% pada siklus I menjadi 77,50 dengan ketuntasan klasikal 88% pada siklus II. Dari hasilpenelitian dapat disimpulkan bahwa Penerapan Model Pembelajaran Kooperatif tipe Jigsaw malalui Media VCD sebagai media pembelajaran dapat meningkatkan hasil belajar fisika siswa, sehingga dapat dijadikan alternatifpilihan pada pembelajarn fisika.
Constitutively reduced sensory capacity promotes better recovery after spinal cord-injury (SCI) in blind rats of the dystrophic RCS strain
Authors: Rink Svenja , Bendella Habib , Alsolivany Kurdin , Meyer Carolin , Woehler Aliona , Jansen Ramona , Isik Zeynep , Stein Gregor , Wennmachers Sina , Nakamura Makoto , Angelov Doychin N. 
Published: March 2018

Background: We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain “Royal College of Surgeons” (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. Objective: The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI. Methods: All rats were subjected to severe compression of the spinal cord at vertebra Th8, spinal cord segment Th10. Recovery of locomotion was analyzed at 1, 3, 6, 9, and 12 weeks after SCI using video recordings of beam walking and inclined ladder climbing. Five functional parameters were studied: foot-stepping angle (FSA), rump-height index (RHI) estimating paw placement and body weight support, respectively, number of correct ladder steps (CLS) assessing skilled hindlimb movements, the BBB-locomotor score and an established urinary bladder score (BS). Sensitivity tests were followed by electrophysiological measurement of M- and H-wave amplitudes from contractions of the plantar musculature after stimulation of the tibial nerve. The closing morphological measurements included lesion volume and expression of astro- and microglia below the lesion. Results: Numerical assessments of BBB, FSA, BS, lesion volume and GFAP-expression revealed no significant differences between both strains. However, compared to SD-rats, the blind SD/RCS animals significantly improved RHI and CLS by 6 – 12 weeks after SCI. To our surprise the withdrawal latencies in the blind SD/RCS rats were longer and the amplitudes of M- and H-waves lower. The expression of IBA1-immunoreactivity in the lumbar enlargement was lower than in the SD-animals. Conclusion: The longer withdrawal latencies suggest a decreased sensitivity in the blind SD/RCS rats, which promotes better recovery after SCI. In this way our results provide indirect support to earlier work showing, that hypersensitivity and chronic pain after contusive SCI impair the recovery of locomotor function.
Loss to follow-up and Associated Factors of Patients in the National AIDS Program in Thailand
Authors: Teeraananchai Sirinya , Kerr Stephen J , Ruxrungtham Kiat , Avihingsanon Anchalee , Chaivooth Suchada , Teeraratkul Achara , Bhakeecheep Sorakij , Ongwandee Sumet , Thanprasertsuk Sombat , Law Matthew G 
Published: March 2018

Background Loss to follow-up (LTFU) is a crucial indicator to evaluate the effectiveness of HIV care and treatment programmes. We assessed the LTFU rate and associated factors of Thai HIV-infected patients who enrolled in the National AIDS Program (NAP) for two periods: prior to (pre-ART) and after starting ART (ART-patients). Methods Thai HIV patients aged ≥15 years enrolled in NAP from 2008 to 2014. Vital status was ascertained by linkage with the National Death Registry. Competing risk models were used to calculate the adjusted sub-distribution hazards (aSHR) for LTFU for pre-ART and ART-patients, with death considered as a competing risk. Results A total of 157,026 patients registered in care and were included in analyses. The cumulative incidence of LTFU in pre-ART patients at 1 year was 10.2%, whereas in ART-patients it was 12.8%. Among pre-ART patients, younger age (<30 versus ≥45 years, aSHR 1.60, 95% CI 1.49, 1.72), less advanced HIV stage (aSHR 1.29, 95% CI 1.21, 1.37) and higher CD4+ T-cell count (≥350 versus <100, aSHR 6.31, 95% CI 5.74, 6.95) had a higher chance of LTFU. ART-patients with high baseline CD4+ T-cell count (CD4 ≥350 versus CD4 <50, aSHR 2.06, 95% CI 1.97, 2.15) and non-advanced HIV stage had increased risk of LTFU. Conclusions Our findings provide new evidence of the LTFU rate in Thai HIV-infected patients in NAP. Emphasis needs to be placed on improving follow-up in all patients with higher CD4+ T-cell counts. LTFU will be important to monitor as programmes move to commence ART regardless of CD4+ T-cell count.