bluuebunny/crossref_metadata_2025_split huggingface dataset:
The rs11150601 intron variant of SETD1A is associated with female schizophrenia in the UK Biobank cohort
Authors: Lehrer Steven , Rheinstein Peter H. 
Published: December 2024

AbstractBackgroundSchizophrenia is a complex psychiatric disorder with an estimated heritability of 80%. SETD1A, a gene encoding a histone methyltransferase critical for transcriptional regulation, has been identified as a significant risk factor for schizophrenia. Loss-of-function mutations in SETD1A confer up to a 35-fold increased risk, implicating its role in neurodevelopment and synaptic plasticity.MethodsUsing data from the UK Biobank cohort (468,998 participants), we investigated the association of SETD1A variants with schizophrenia, obesity, and hypertension. Schizophrenia cases were identified using ICD-10 codes, while obesity and hypertension were assessed using specific data fields. Genome-wide association analysis was performed using PLINK, and statistical analyses utilized SPSS v26. Logistic regression assessed the impact of SETD1A intron variant (rs11150601) alongside age, obesity, and hypertension on schizophrenia risk.ResultsAmong 1,063 individuals diagnosed with schizophrenia, obesity (p < 0.001) and hypertension (p < 0.001) were significantly more prevalent. The rs11150601 GG genotype was associated with an increased risk of schizophrenia in women (OR 1.6, p < 0.001) but not in men. Logistic regression revealed that obesity, hypertension, and age were independent risk factors for schizophrenia in women. SETD1A genotype exerted a significant sex-specific effect, highlighting its potential role in the biological mechanisms underlying schizophrenia.ConclusionOur findings emphasize the role of SETD1A in the genetic architecture of schizophrenia and its comorbidities, particularly in women. The sex-specific effects of SETD1A variants underscore the importance of incorporating biological sex into studies of psychiatric genetics. Further research is warranted to elucidate the mechanisms by which SETD1A influences neurodevelopment and identify therapeutic strategies targeting its epigenetic functions.Graphical abstractThe rs11150601 intron variant of SETD1A is associated with female schizophrenia but not male schizophrenia.
Intimate Partner Violence Experiences among Men Who Have Sex in Hanoi, Vietnam
Authors: Pham Loc Quang , Sullivan Patrick S. , Gilmore Amanda K. , Kalokhe Ameeta S. , Nguyen Thanh Cong , Nguyen Khanh Duc , Bui Hao Thi Minh , Giang Le Minh 
Published: December 2024

AbstractPurposeIntimate partner violence (IPV) victimization is a pressing issue among men who have sex with men (MSM) and has profound health implications. This study aims to estimate the prevalence of IPV and identify factors associated with its occurrence among MSM in Hanoi, VietnamMethodsA cross-sectional study was conducted from March to May 2023 at an MSM-friendly sexual health clinic in Hanoi. Participants completed a self-administered questionnaire on a tablet after screening for eligibility. IPV victimization was assessed using a 21-item scale (the IPV-GBM scale). Logistic regression models were used to identify factors associated with IPV victimization in the past 12 months.ResultsAmong 309 respondents, the mean age was 28 and half of participants reported using PrEP for 12 months or more. Two-thirds reported IPV victimization in the past 12 months (67%). Emotional IPV (47%) was most prevalent, followed by monitoring (39%), controlling (19%), and physical/sexual IPV (15%). Participants who were reported experiencing IPV in the past 12 months were more likely to be aged ≤ 24 years (aOR = 1.98, 95% CI: 1.14, 3.44), to report preferring the insertive sexual role (aOR = 2.02, 95% CI: 1.10, 3.70), or to report having more sexual partners (2-5 partners vs ≤ 1 partner: aOR = 2.02, 95% CI: 1.10, 3.70; ≥ 5 partners vs. ≤ 1 partner: aOR = 2.02, 95% CI: 1.10, 3.70).ConclusionsIPV victimization among MSM on PrEP in Hanoi is highly prevalent. Tailored interventions are needed to address these vulnerabilities and promote safer behaviors and healthier relationships. Efforts should prioritize younger MSM. Further research is necessary to explore IPV dynamics across diverse settings.
Directionality of transcriptional regulatory elements
Authors: Chen You , Shah Sagar R. , Leung Alden K. , Paramo Mauricio I. , Cochran Kelly , Kundaje Anshul , Clark Andrew G. , Lis John T. , Yu Haiyuan 
Published: December 2024

AbstractDivergent transcription is a critical marker of active transcriptional regulatory elements (TREs), including enhancers and promoters, in mammals. However, distal elements with unidirectional transcriptional patterns are often overlooked, leaving their identity and function poorly understood. Here, we performed a systematic comparison between divergent and unidirectional elements, revealing their distinct architectural and functional features. Our analysis also shows that unidirectional elements have younger sequence ages and are under weaker evolutionary constraints than divergent elements, indicating that they may represent a unique category of genomic regulatory function with more recent origins. Notably, we observed that some transcription factors, including CTCF, AP1, SP, and NFY, exhibit dual roles in modulating the directionality of TREs, either activating or repressing nascent transcription in a position-dependent manner. Overall, the elucidation of directionality enhances our understanding of the diverse architectural models, functional features, evolutionary dynamics, and regulatory logic of TREs.
Identification and developmental profiling of microRNAs in the acoel wormHofstenia miamia
Authors: Duan Ye , Segev Tomer , Veksler-Lublinsky Isana , Ambros Victor , Srivastava Mansi 
Published: December 2024

ABSTRACTThe acoel wormHofstenia miamia (H. miamia)has recently emerged as a model organism for studying whole-body regeneration and embryonic development. Previous studies suggest that post-transcriptional mechanisms likely play important roles in whole-body regeneration. Here, we establish a resource for studyingH. miamiamicroRNA-mediated gene regulation, a major aspect of post-transcriptional control in animals. Using small RNA-sequencing samples spanning key developmental stages, we annotatedH. miamiamicroRNAs. Our analysis uncovered a total of 1,050 microRNA loci, including 479 high-confidence loci based on structural and read abundance criteria. Comparison of microRNA seed sequences with those in other bilaterian species revealed thatH. miamiaencodes the majority of known conserved bilaterian microRNA families and that several microRNA families previously reported only in protostomes or deuterostomes likely have ancient bilaterian origins. We profiled the expression dynamics of theH. miamiamiRNAs across embryonic and post-embryonic development. We observed that thelet-7andmir-125microRNAs are unconventionally enriched at early embryonic stages. To generate hypotheses for miRNA function, we annotated the 3’ UTRs ofH. miamiaprotein-coding genes and performed miRNA target site predictions. Focusing on genes that are known to function in the wound response, posterior patterning, and neural differentiation inH. miamia, we found that these processes may be under substantial miRNA regulation. Notably, we found that miRNAs in MIR-7 and MIR-9 families which have target sites in the posterior genesfz-1,wnt-3, andsp5are indeed expressed in the anterior of the animal, consistent with a repressive effect on their corresponding target genes. Our annotation offers candidate miRNAs for further functional investigation, providing a resource for future studies of post-transcriptional control during development and regeneration.
Stress during puberty and adulthood pregnancy impact histone acetylation regulators in the hypothalamus
Authors: Luther Laiklyn A.M. , Higley Samantha L. , Morrison Kathleen E. 
Published: December 2024

AbstractUndergoing stressful events during puberty puts women at risk for a variety of negative outcomes, and this risk is heightened if they become pregnant later in life. We previously demonstrated that stress during puberty combined with pregnancy in adulthood led to a blunted response of the hypothalamic-pituitary-adrenal stress axis in humans and mice. We have begun to understand the mechanisms underlying this effect by examining the paraventricular nucleus of the hypothalamus (PVN), a key regulator of the HPA axis. Prior studies uncovered an increase in chromatin openness within the PVN of the at-risk mice, with bioinformatic analyses implicating histone acetylation in this increased openness. Here, we measured the activity of histone acetyltransferase (HATs) and histone deacetylase (HDACs), the writers and erasers of histone acetylation, within the PVN to further characterize how stress during puberty and pregnancy may be interacting to produce a blunted stress response. We found that histone acetylation tone within the PVN is predictive of prior transcriptional and chromatin results, with pregnant, pubertally stressed females having a pro-acetylation tone within the PVN. These findings establish a role for regulators of acetylation in the open chromatin landscape characteristic in the PVN of pregnant, pubertally stressed females. Overall, this study provides insight into the epigenetic mechanisms underlying female-relevant risk for stress dysregulation, a central endophenotype of affective disorders.
Have you heard of Rift Valley fever? Findings from a multi-country study in East and Central Africa
Authors: Odinoh Raymond , Dawa Jeanette , Situma Silvia , Nyakarahuka Luke , Lepore Luciana , Vanlerberghe Veerle , Nasimiyu Carolyne , Makiala Sheila , Ifufa Christian , Mukadi Daniel , Viala Herve , Owor Nicholas , Bakamutumaho Barnabas , Ndumu Deo , Masumu Justin , Breiman Robert F. , Njenga Kariuki 
Published: December 2024

AbstractIntroductionRift Valley Fever (RVF) has caused outbreaks in Africa, impacting human health and animal trade. Recently, sporadic detections among humans and animals in East Africa have replaced large-scale outbreaks. We assessed RVF knowledge levels in East and Central Africa across countries with different epidemiological profiles.Materials and MethodsIndividuals aged ≥10 years with acute febrile illness were enrolled from six health facilities in Kenya, Uganda, and the Democratic Republic of Congo (DRC). Sociodemographic information was collected and participants asked questions on RVF transmission, symptoms, prevention, and control. Blood samples were tested for anti-RVF antibodies (IgG and IgM). Knowledge was categorized as absent, basic, or advanced. Descriptive and ordinal logistic regression analysis identified factors associated with RVF knowledge.ResultsAmong 4,806 participants (median age 31, IQR 22–44, 57.5% female), only 20.5% demonstrated any RVF knowledge (16.4% basic, 4.1% advanced). Knowledge levels varied by country: DRC (3.1%), Uganda (16.1%), and Kenya (42.6%). Factors associated with RVF knowledge included age 20–40 years aOR 1.72 (95%CI 1,24–2.22) and >40 years 2.42 (95%CI 1.74–3.420), male gender aOR 1.54 (95%CI 1.31–1.82), healthcare workers aOR 7.95 (95%CI 5.25–12.1), residence in Kenya aOR 23.5 (95%CI 15.8–35.8) or Uganda 5.4 (95%CI 3.68–8.38), completing primary education aOR 3.24 (95%CI 1.94–5.75) with advanced education shown to increase knowledge, postgraduate aOR 11.5 (95%CI 4.0– 32.4). Other factors included presence of livestock within the homes aOR 1.30 (95%CI 1.06– 1.59) and prevention of mosquito bites aOR 1.55 (95%CI 0.46–0.66). Animal farmers, butchers, and those with close animal contact showed no association, despite being at-risk populations.ConclusionRVF knowledge was low overall, varying by country, age, education, and environmental factors. Increased awareness is crucial for high-exposure groups in all regions, particularly in Uganda, where exposure is higher, but knowledge remains low.
Scaling Violation in Power Corrections to Energy Correlators from the Light-Ray Operator Product Expansion
Authors: Chen Hao , Monni Pier Francesco , Xu Zhen , Zhu Hua Xing 
Published: December 2024

In recent years, energy correlators have emerged as a powerful tool to explore the field theoretic structure of strong interactions at particle colliders. In this Letter we initiate a novel study of the nonperturbative power corrections to the projected N-point energy correlators in the limit where the angle between the detectors is small. Using the light-ray operator product expansion as a guiding principle, we derive the power corrections in terms of two nonperturbative quantities describing the fragmentation of quarks and gluons. In analogy with their perturbative leading-power counterpart, we show that power corrections obey a classical scaling behavior that is violated at the quantum level. This crucially results in a dependence on the hard scale Q of the problem that is calculable in perturbation theory. Our analytic predictions are successfully tested against Monte Carlo simulations for both lepton and hadron colliders, marking a significant step forward in the understanding of these observables.

Published by the American Physical Society
2024
First-Principles Prediction of Structural Distortions in the Cuprates and Their Impact on the Electronic Structure
Authors: Jin Zheting , Ismail-Beigi Sohrab 
Published: December 2024

Materials-realistic microscopic theoretical descriptions of copper-based superconductors are challenging due to their complex crystal structures combined with strong electron interactions. Here, we demonstrate how density functional theory can accurately describe key structural, electronic, and magnetic properties of the normal state of the prototypical cuprate Bi2Sr2CaCu2O8+x (Bi-2212). We emphasize the importance of accounting for energy-lowering structural distortions, which then allows us to (a) accurately describe the insulating antiferromagnetic (AFM) ground state of the undoped parent compound (in contrast to the metallic state predicted by previous studies); (b) identify numerous low-energy competing spin and charge stripe orders in the hole-overdoped material nearly degenerate in energy with the AFM ordered state, indicating strong spin fluctuations; (c) predict the lowest-energy hole-doped crystal structure including its long-range structural distortions and oxygen dopant positions that match high-resolution scanning transmission electron microscopy measurements; and (d) describe electronic bands near the Fermi energy with flat antinodal dispersions and Fermi surfaces that are in agreement with angle-resolved photoemission spectroscopy (ARPES) measurements and provide a clear explanation for the structural origins of the so-called “shadow bands.” We also show how one must go beyond band theory and include fully dynamic spin fluctuations via a many-body approach when aiming to make quantitative predictions to measure the ARPES spectra in the overdoped material. Finally, regarding spatial inhomogeneity, we show that the local structure at the CuO2 layer, rather than dopant electrostatic effects, modulates the local charge-transfer gaps, local correlation strengths, and by extension the local superconducting gaps.

Published by the American Physical Society
2024
Variable stoichiometry and a salt–cocrystal intermediate in multicomponent systems of flucytosine: structural elucidation and their impact on stability
Authors: Kanagavel Manimurugan , Balasubramanian Sridhar , Nechipadappu Sunil Kumar 
Published: December 2024

New cocrystals and a salt–cocrystal intermediate system involving the antifungal drug flucytosine (FCY) and various coformers including caffeic acid (CAF), 2-chloro-4-nitrobenzoic acid (CNB), hydroquinone (HQN), resorcinol (RES) and catechol (CAL), are reported. The crystal structures of the prepared multicomponent systems were determined through SC-XRD analysis and characterized by different solid-state techniques. All FCY multicomponent systems crystallize in anhydrous form with different stoichiometric ratios. The cocrystals FCY–HQN, FCY–RES and FCY–CAL crystallize in 2:0.5, 2:0.5 and 3:2 stoichiometric ratios respectively. In contrast, FCY–CAF and FCY–CNB crystallize in a 1:1 stoichiometric ratio. The FCY–CAF cocrystal is formed via an acid–pyrimidine heterosynthon. Due to the partial proton transfer from the acid group of CNB to FCY, a three-point homosynthon is observed between two FCY molecules and the molecules interact via an N—H...O hydrogen bond between FCY and CNB. In FCY phenolic cocrystals, a single-point O—H...O hydrogen bond is observed. The formation of cocrystals and salt–cocrystal intermediate was further confirmed by difference Fourier map analysis and bond angle differences. Except for FCY–CAL, all the multicomponent systems were reproduced in the bulk scale for further characterization. A detailed Crystal Structural Database search was carried out on the multicomponent systems of FCY with acid coformers and we evaluated the formation of cocrystals/salt based on the ΔpKa
values, the difference in the bond distances and bond angles. Additionally, the prepared multicomponent systems exhibited hydration stability for one month under accelerated conditions [40 (2) °C and relative humidity 90–95 (5)%].
Defend what you love and what is fair: defensive word-of-mouth toward a brand
Authors: Lai Yueh-Hysuan , Huang Mei-Tzu , Lin Tom M.Y. 
Published: December 2024

PurposeThis study investigates the mechanism of defensive word-of-mouth (WOM), which refers to consumers responding to unfair negative online reviews of a brand with which they identify.Design/methodology/approachStudy 1 employs an experimental design that manipulates brand identification and the perceived fairness of negative WOM, using a gift card choice scenario to measure decision-making behavior. Study 2 involves a real event with Google reviews and follows a quasi-experimental design, manipulating identification with the university and using Google Maps star ratings to measure brand attitude.FindingsConsumers with high brand identification are more likely to defend the brand when confronted with unfair negative WOM. However, they do not always exhibit defensive WOM in fair cases. Furthermore, the results show that the defensive WOM can strengthen consumers’ brand attitude and supportive behavior.Practical implicationsEncouraging defensive WOM by mobilizing brand advocates and highlighting the unfairness of negative WOM could be a practical strategy to defend the brand and minimize the risk of online firestorms. Notably, defensive WOM itself strengthens the relationship between consumers and the brand.Originality/valueThis study proposes a mechanism for the defensive WOM phenomenon and demonstrates that the rebound effect in brand attitude caused by negative WOM comes from consumers’ willingness to express defensive WOM. We draw on self-affirmation theory to address the gap in theoretical explanations for defensive WOM. This contributes to the literature on self-identity and WOM research by showing that consumers defend their identities through WOM communication.
Integrating quality into the reverse logistics in construction: an empirical study in South Australia
Authors: Wijewickrama M.K.C.S. , Chileshe Nicholas , Rameezdeen Raufdeen , Ochoa J. Jorge 
Published: November 2024

PurposeInferior quality reprocessed products hinder the successful adoption of reverse logistics supply chains (RLSCs) of demolition waste (DW) in the construction industry. Therefore, an information-centric quality assurance system (QAS), including process, people, policy and technology aspects, plays an important role in RLSCs, yet none of the previous studies empirically delved into this. Therefore, this study aims to establish how aspects of the process, people, policy and technology contribute to creating an information-centric QAS for RLSCs.Design/methodology/approachInitially, an extensive literature review was undertaken. Then, following a qualitative approach, 20 semi-structured interviews were conducted with internal stakeholders of the RLSCs in the South Australian construction industry. The collected data were analysed using directed content analysis.FindingsThis study empirically established how the aspects of process, people, policy and technology contribute to quality assurance (QA) in RLSCs. The process involves practices and approaches for QA. Experienced and knowledgeable people should undertake this process, complying with the policies and using new or available technologies. Each aspect provides useful information that should be shared and communicated with the other aspects to create an integrated QAS for the RLSCs.Originality/valueThe current study made a significant contribution by empirically establishing that an information-centric system of process, people, policy and technology was needed for QA in RLSCs to produce quality outputs. This QAS provides useful insights for industry practitioners, government and policymakers about the aspects they should embrace in enforcing QA in RLSCs.
Perceived organizational support and job burnout with the mediating mechanism of self-esteem
Authors: Alimbekov Akmatali , Azhykulov Saparbek , Imanbaev Askarbek , Zuluev Bekmurza , Koilubaeva Burulcha , Sagyndykova Rakhat , Muratbaev Bakyt 
Published: November 2024

PurposeThis study seeks to unravel the psychological well-being of education sector professionals by exploring the mediating role of self-esteem in the relationship between perceived organizational support and burnout among university teachers.Design/methodology/approachThis survey-based study employs a relational, cross-sectional model to determine the relationship between educational technology proficiency, self-esteem and burnout behaviors. Additionally, as the study aims to determine the mediating role of self-esteem, the mediation model is employed. The study sample consists of 407 university teachers who completed evaluations in September 5–30, 2023. Alongside demographic information, data were collected using the following instruments: Perceived Organizational Support Scale, Rosenberg Self-Esteem Scale and Teacher Burnout Scale. Construct validity and path analyses were conducted using the AMOS software. Normality tests, descriptive analyses and correlation calculations were performed using SPSS software.FindingsResults indicate that perceived organizational support negatively affects burnout and positively influences self-esteem levels. Additionally, self-esteem negatively impacts burnout and fully mediates the relationship between perceived organizational support and burnout. Hence, the effect of organizational support on burnout is mediated through self-esteem, indicating that supportive organizational practices not only mitigate burnout but also enhance teaching staff’s self-esteem. Based on these findings, organizational support strategies hold promise for reducing burnout and bolstering individual confidence and self-esteem among university teachers.Originality/valueGiven the intricate job structure of university teachers in the education sector and their interactions with students, stress, high expectations and a perpetually evolving learning environment can impact their psychological well-being. In this context, perceived organizational support, burnout, and self-esteem emerge as pivotal factors shaping the work lives of university teachers. While previous studies have explored the relationship between perceived organizational support and self-esteem as well as self-esteem and burnout among academics, this study determines how self-esteem plays a mediating role in establishing a link between the two variables.