bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Aortic Stenosis With a Self-Expanding, Resheathable Transcatheter Valve
Authors: Linke Axel , Holzhey David , Möllmann Helge , Manoharan Ganesh , Schäfer Ulrich , Frerker Christian , Worthley Stephen G. , van Boven A.J. , Redwood Simon , Kovac Jan , Butter Christian , Søndergaard Lars , Lauten Alexander , Schymik Gerhard , Walther Thomas 
Published: February 2018

Background—
The aim of the Portico TAVI (transcatheter aortic valve implantation) system study was to evaluate outcomes ≤1 year after implantation of a novel resheathable, self-expanding TAVI system in a multicenter patient population with severe aortic stenosis (AS).

Methods and Results—

High-risk patients (n=222) with symptomatic severe AS (mean age, 83.0±4.6 years; 74.3% women) were enrolled across 12 centers in Europe and Australia. The study’s primary end point was all-cause mortality at 30 days. A total of 209 patients who received the Portico TAVI system were available for follow-up after the 30-day visit. Data collection included hemodynamic assessment by echocardiography with core laboratory evaluation and assessment of functional status. Valve Academic Research Consortium–defined adverse events were adjudicated by an independent Clinical Events Committee. TAVI using the Portico valve led to a significant and persistent improvement in aortic valve function at 1 year. More than mild paravalvular leak was present in 5.7% and 7.5% of patients at 30 days and 1 year, respectively. Kaplan–Meier estimates at 30 days and 1 year were 3.6% and 13.8% for all-cause mortality, 3.6% and 9.6% for cardiovascular mortality, and 3.2% and 5.8% for major (disabling) stroke. After 30 days and ≤1 year of follow-up, adverse events included stage 3 acute kidney injury (n=3), major vascular complications (n=5), and life-threatening/disabling bleeding (n=3). Overall permanent pacemaker rate was 14.7%. At 1 year, 74.8% improved ≥1 New York Heart Association class compared with baseline (
P
<0.0001).

Conclusions—
The Portico TAVI system is safe and effective at 1 year, yielding low mortality and stroke rates in high-risk patients with severe AS.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01493284.
Preliminary assessment of genetic diversity and population connectivity of the Mugger Crocodile in Iran
Authors: Campos João Carlos , Mobaraki Asghar , Abtin Elham , Godinho Raquel , Brito José Carlos 
Published: February 2018

The Mugger Crocodile (Crocodylus palustris) is a threatened reptile inhabiting the Indian Sub-continent and Western Asia. Despite its “Vulnerable” conservation status, data about population genetic structure and connectivity are unavailable. This study makes a preliminary assessment of the genetic diversity, population structure and habitat connectivity of C. palustris in Iran. Ten tissue samples collected along the Sarbaz-Bahukalat basins were analysed and a set of 12 microsatellites was genotyped. Genetic diversity indices were estimated and population substructuring was assessed through Bayesian clustering analysis. Potential connectivity was verified through Remote Sensing water indexes, further implemented in a circuit analysis. Low genetic diversity was observed (mean observed heterozygosity = 0.35; mean expected heterozygosity = 0.43) and no population structure was found (K = 1). Water index and circuit analysis suggested possible connection among sites. This study highlights the potential vulnerability of crocodile populations and the importance of habitat connectivity for their persistence in the arid regions of Iran.
Diagnosing Tongue Base Obstruction in Pierre Robin Sequence Infants
Authors: Lee Jake J. , Ford Matthew D. , Tobey Allison B. , Jabbour Noel 
Published: February 2018

Objective: To investigate whether awake endoscopy can diagnose base-of-tongue obstruction as reliably as sleep endoscopy in infants with Pierre Robin sequence (PRS). Design: The study was retrospective with the clinicians blinded to patient identity. Endoscopy findings were assessed and measured by the performing pediatric otolaryngologist. Setting: Tertiary care children’s hospital. Patients: All infants with PRS managed between January 2005 and July 2015 were included. There were 141 patients, of which 35 underwent both awake endoscopy (AE) and drug-induced sleep endoscopy (DISE). Interventions: Bedside AE and DISE in the operating room. Main Outcome Measures: Presence of moderate or severe base-of-tongue collapse was assessed. Sensitivity, specificity, and positive likelihood ratio of AE findings as well as intertest differences between AE and DISE were calculated. Results: AE had 50.0% sensitivity (95% confidence interval [CI] 27.2%-72.8%) and 86.7% specificity (95% CI 59.5%-98.3%) for detecting base-of-tongue obstruction compared to DISE; false negative rate was 50.0% (n = 10). Positive likelihood ratio was 3.75 (CI 0.96-14.65). Compared to AE, DISE demonstrated significantly more cases of base-of-tongue obstruction ( P = .039). Conclusions: Bedside AE has low sensitivity for detecting base-of-tongue collapse in infants with PRS. Because of the substantial false negative rate, AE may not be a reliable diagnostic modality for ruling out base-of-tongue obstruction in this susceptible population. DISE may be indicated in high-risk patients to avoid underdiagnosing upper airway obstruction.
Morphometrics of complex cell shapes: lobe contribution elliptic Fourier analysis (LOCO-EFA)
Authors: Sánchez-Corrales Yara E. , Hartley Matthew , van Rooij Jop , Marée Athanasius F.M. , Grieneisen Verônica A. 
Published: February 2018

ABSTRACT
Quantifying cell morphology is fundamental to the statistical study of cell populations, and can help unravel mechanisms underlying cell and tissue morphogenesis. Current methods, however, require extensive human intervention, are highly parameter sensitive, or produce metrics that are difficult to interpret biologically. We therefore developed a method, lobe contribution elliptical Fourier analysis (LOCO-EFA), which generates from digitalised two-dimensional cell outlines meaningful descriptors that can be directly matched to morphological features. This is shown by studying well-defined geometric shapes as well as actual biological cells from plant and animal tissues. LOCO-EFA provides a tool to phenotype efficiently and objectively populations of cells, here demonstrated by applying it to the complex shaped pavement cells of Arabidopsis thaliana wild-type and speechless leaves, and Drosophila amnioserosa cells. To validate our method's applicability to large populations, we analysed computer-generated tissues. By controlling in silico cell shape, we explored the potential impact of cell packing on individual cell shape, quantifying through LOCO-EFA deviations between the specified shape of single cells in isolation and the resultant shape when they interact within a confluent tissue.
Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria
Authors: Ugarte-Uribe Begoña , Prévost Coline , Das Kushal Kumar , Bassereau Patricia , García-Sáez Ana J. 
Published: February 2018

ABSTRACT
Dynamin-related protein 1 (Drp1), an 80 kDa mechanochemical GTPase of the dynamin superfamily, is required for mitochondrial division in mammals. Despite the role of Drp1 dysfunction in human disease, its molecular mechanism remains poorly understood. Here, we examined the effect of Drp1 on membrane curvature using tubes pulled from giant unilamellar vesicles (GUVs). We found that GTP promoted rapid rearrangement of Drp1 from a uniform distribution to discrete foci, in line with the assembly of Drp1 scaffolds at multiple nucleation sites around the lipid tube. Polymerized Drp1 preserved the membrane tube below the protein coat, also in the absence of pulling forces, but did not induce spontaneous membrane fission. Strikingly, Drp1 polymers stabilized membrane curvatures similar to those of constricted mitochondria against pressure changes. Our findings support a new model for mitochondrial division whereby Drp1 mainly acts as a scaffold for membrane curvature stabilization, which sets it apart from other dynamin homologs.
Dual-energy CT iodine maps as an alternative quantitative imaging biomarker to abdominal CT perfusion: determination of appropriate trigger delays for acquisition using bolus tracking
Authors: Skornitzke Stephan , Fritz Franziska , Mayer Philipp , Koell Marco , Hansen Jens , Pahn Gregor , Hackert Thilo , Kauczor Hans-Ulrich , Stiller Wolfram 
Published: February 2018

Objective:
Quantitative evaluation of different bolus tracking trigger delays for acquisition of dual energy (DE) CT iodine maps as an alternative to CT perfusion.

Methods:
Prior to this retrospective analysis of prospectively acquired data, DECT perfusion sequences were dynamically acquired in 22 patients with pancreatic carcinoma using dual source CT at 80/140 kVp with tin filtration. After deformable motion-correction, perfusion maps of blood flow (BF) were calculated from 80 kVp image series of DECT, and iodine maps were calculated for each of the 34 DECT acquisitions per patient. BF and iodine concentrations were measured in healthy pancreatic tissue and carcinoma. To evaluate potential DECT acquisition triggered by bolus tracking, measured iodine concentrations from the 34 DECT acquisitions per patient corresponding to different trigger delays were assessed for correlation to BF and intergroup differences between tissue types depending on acquisition time.

Results:
Average BF measured in healthy pancreatic tissue and carcinoma was 87.6 ± 28.4 and 38.6 ± 22.2 ml/100 ml min–1, respectively. Correlation between iodine concentrations and BF was statistically significant for bolus tracking with trigger delay greater than 0 s (rmax = 0.89; p &lt; 0.05). Differences in iodine concentrations between healthy pancreatic tissue and carcinoma were statistically significant for DECT acquisitions corresponding to trigger delays of 15–21 s (p &lt; 0.05).

Conclusion:
An acquisition window between 15 and 21 s after exceeding bolus tracking threshold shows promising results for acquisition of DECT iodine maps as an alternative to CT perfusion measurements of BF.

Advances in knowledge:
After clinical validation, DECT iodine maps of pancreas acquired using bolus tracking with appropriate trigger delay as determined in this study could offer an alternative quantitative imaging biomarker providing functional information for tumor assessment at reduced patient radiation exposure compared to CT perfusion measurements of BF.
Genetic and environmental contributions to psychological resilience and coping
Authors: Navrady Lauren B , Zeng Yanni , Clarke Toni-Kim , Adams Mark J , Howard David M , Deary Ian J , McIntosh Andrew M 
Published: February 2018

Background: Twin studies indicate that genetic and environmental factors contribute to both psychological resilience and coping style, but estimates of their relative molecular and shared environmental contributions are limited. The degree of overlap in the genetic architectures of these traits is also unclear. Methods: Using data from a large population- and family-based cohort Generation Scotland (N = 8,734), we estimated the genetic and shared environmental variance components for resilience, task-, emotion-, and avoidance-oriented coping style in a linear mixed model (LMM). Bivariate LMM analyses were used to estimate the genetic correlations between these traits. Resilience and coping style were measured using the Brief Resilience Scale and Coping Inventory for Stressful Situations, respectively. Results: The greatest proportion of the phenotypic variance in resilience remained unexplained, although significant contributions from common genetic variants and family-shared environment were found. Both task- and avoidance-oriented coping had significant contributions from common genetic variants, sibling- and couple-shared environments, variance in emotion-oriented coping was attributable to common genetic variants, family- and couple-shared environments. The estimated correlation between resilience and emotion-oriented coping was high for both common-variant-associated genetic effects (rG = -0.79, se = 0.19), and for the additional genetic effects from the pedigree (rK = -0.94, se = 0.30). Genetic correlations between resilience and task- and avoidance-oriented coping did not meet statistical significance. Conclusions: Both genetics and shared environmental effects were major contributing factors to coping style, whilst the variance in resilience remains largely unexplained. Strong genetic overlap between resilience and emotion-oriented coping suggests a relationship whereby genetic factors that increase negative emotionality also lead to decreased resilience. We suggest that genome-wide family-based studies of resilience and coping may help to elucidate tractable methodologies to identify genetic architectures and modifiable environmental risk factors to protect against psychiatric illness, although further work with larger sample sizes is needed.
ПОСТРОЕНИЕ СОЦИОЛОГИЧЕСКОГО ПОРТРЕТА СТУДЕНТА УЧЕБНОГО ЗАВЕДЕНИЯ СРЕДНЕГО ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ
Authors: Borodina Natalia Valerievna , Ukraintseva Irina Ivanovna , Khovakova Anna Leonidovna 
Published: February 2018

Цель. Статья посвящена актуальной проблеме подготовки студентов среднего профессионального образования (СПО) по востребованным и перспективным профессиям и специальностям, которая в данный момент становится все более значимой в нашей стране. В статье осуществлен теоретический анализ понятий «социальный портрет», «социологический портрет». Авторы ставят целью раскрыть свой подход к структурированию механизма социологического портретирования студента, обучающегося по СПО.Метод или методология проведения работы. Основу исследования образуют феноменологический, системный, обобщенный методы, моделирование, а также эмпирические методы.Результаты. Результаты работы заключаются в том, что авторы выявили новые грани проблемы и получили объективные знания об особенностях профессиональных ожиданий и предпочтений студентов СПО в ходе апробации исследования по теме «Формирование социологического портрета абитуриентов, студентов и выпускников образовательных программ СПО, обеспечивающих подготовку по наиболее востребованным, новым и перспективным профессиям и специальностям СПО» в Сочинском государственном университете. Авторы представляют подход к совершенствованию механизма социологического портретирования студента в среднем профессиональном образовании.Область применения результатов. Результаты исследования могут быть применены в сфере среднего профессионального образования и социологического прогнозирования.
РЕАЛИЗАЦИЯ СИСТЕМАТИЗИРОВАННОГО ПРОЦЕССА ФОРМИРОВАНИЯ СОВРЕМЕННОГО МЕНЕДЖЕРА
Authors: Bazavlutskaya Liliya Mikhailovna , Alekseeva Lyubov Petrovna , Konyaeva Elena Alexandrovna 
Published: February 2018

Цель. Статья посвящена актуальной проблеме формирования профессиональных качеств современного менеджера, способного действовать в новых экономических условиях и обеспечивать их совершенствование и необходимостью разработки систематизированного процесса для эффективного формирования современного менеджера в системе управления персоналом образовательной организации.Метод или методология проведения работы. Основу исследования образуют системный, деятельностный и культурологический подходы, а также общенаучные методы классификации, обобщения и сравнения.Результаты. Результаты работы заключаются в том, что на основе системного, деятельностного и культурологического подходов предложен систематизированный процесс формирования современного менеджера, который разработан с учетом требований социального заказа и профессиональной подготовки, включает оценочно-коррекционный компоненты и характеризуется содержательной вариативностью, устойчивостью и адаптивностью; реализуется с учетом принципов диалогического общения, актуализации субъектного опыта специалиста.Область применения результатов. Результаты исследования могут быть применены в сфере управления персоналом образовательной организации.
ИССЛЕДОВАНИЕ ВЗАИМОСВЯЗИ СПОСОБНОСТИ К САМОРЕГУЛЯЦИИ ДЕЯТЕЛЬНОСТИ И МОТИВАЦИИ ДОСТИЖЕНИЙ, СИЛЫ ВОЛИ, ТВОРЧЕСКОГО ПОТЕНЦИАЛА ЛИЧНОСТИ СТУДЕНТОВ – БУДУЩИХ ПЕДАГОГОВ
Authors: Kisljаkova Lyubov’ Petrovna , Zobnina Tat’jаna Venerovna 
Published: February 2018

К настоящему времени выполнен ряд исследований, посвященных изучению регуляторных процессов деятельности у студентов вузов, обучающихся по разным направлениям и профилям подготовки. Вместе с тем особенности взаимосвязи способности к саморегуляции деятельности и индивидуально-психологических качеств личности студентов – будущих педагогов изучены недостаточно. Понимание специфики этих взаимосвязей может стать основой разработки комплексной программы развития этих качеств у будущих педагогов в процессе их подготовки к предстоящей профессиональной деятельности.Целью данной статьи является освещение результатов проведенного авторами корреляционного исследования взаимосвязи уровня развития индивидуальной системы осознанной саморегуляции произвольной активности и мотивации достижений, силы воли, творческого потенциала личности студентов – будущих педагогов.Методология и методика исследования. В основу исследования положены принципы детерминизма, единства сознания и деятельности, развития, системности. В ходе исследования использовались следующие психодиагностические методики: «Стиль саморегуляции поведения (ССПМ)» (автор В.И. Моросанова), «Диагностика силы воли» (автор Н.Н. Обозов), «Мотивация достижения успеха и мотивации избегания неудач» (МУН) (автор А.А. Реан), методика «Каков Ваш творческий потенциал?»Результаты. Проведенное исследование позволило выявить положительные статистически значимые взаимосвязи между общим уровнем саморегуляции произвольной активности, регуляторными процессами планирования, прогнозирования, моделирования, оценивания результатов деятельности и такими индивидуально-психологическими качествами личности студентов – будущих педагогов, как мотивация достижений, сила воли, творческий потенциал.Область применения результатов. Результаты исследования могут быть использованы в работе преподавателей, кураторов, тьютеров студенческих групп.
Radiation Situation at the Tailing Dump of the Stepnogorsk Mining-Chemical Combine and Adjacent Territories. Message I
Authors: Казымбет П. , Kazymbet P. , Бахтин М. , Bahtin M. , Кашкинбаев Е. , Kashkinbaev E. , Джанабаев Д. , Dzhanabaev D. , Джаутбаева Ж. , Dzhautbaeva Zh. , Шарипов М. , Sharipov M. 
Published: February 2018

Purpose: Assessment of the radiation situation at the tailing dump of the Stepnogorsk Mining-Chemical Combine (SMCC) and the settlements around.
Material and methods: The tailing dumps of the SMCC and the settlements near located of Aksu, Kvartsytka and Zavodskaya were objects of the radioecological research. Field expedition studies were performed during the summer period and consisted in carrying out a detailed gamma survey of the territory of the investigated objects and settlements, sampling of surface waters, vegetation, surface and layered soil samples. In settlements, along with sampling and studying the gamma background, the equivalent equilibrium volume activity of radon daughters in residential and industrial premises was determined. To determine the concentrations of the studied radionuclides a background was selected, within which the levels of their global deposition were studied. To calculate the individual effective radiation dose of the population the National Radiation Protection Board methodology was used as the basis.
Results: In the northern part of the tailing dump of the SMCC in the adjoining territory, a radioactive contamination site was found where the specific activity values for 226Ra, 232Th and 210Pb reach values of 1500–2000 Bq/kg. On the territory of the Aksu settlement, 5 local areas with the area from 25 to 1000 m2 were found, with the intensity of ambient dose equivalent of gamma radiation from 0.39 to 0.86 µSv/h. In the Zavodskaya village, two areas with increased levels of gamma radiation intensity were identified.
Conclusion: The obtained results of field work and laboratory analytical studies testify to the negative impact of the tailing dump of the SMCC on the environment of adjacent territories, expressed in contamination of soil, water and vegetation with radionuclides. The nature of the abnormal areas on the territory of the settlements of Aksu and Zavodskaya excludes their origin from the tailing dump of the SMCC. The appearance of these areas of contamination may be due to the use of materials of the 3rd class in sanitary and hygienic standards for improvement and road construction. The probable annual effective dose for the population living in the radioactive local areas of the Aksu ~6.5 mSv/year, at the normal rate of 1 mSv/year from man-made radiation sources.
Innovative Approach to the Integration of Federal State Standard and Professional Standard
Authors: Романченко М. , Romanchenko M. , Филиппов Б. , Filippov B. 
Published: February 2018

The article presents a study of the problems of integrating Federal state and professional standards in the training of specialists with secondary vocational education institutions. Federal state standard of new generation set up for the teachers of special disciplines of secondary vocational education institutions the problem of creating conditions to ensure the implementation of standard requirements to results of education, and the formation of professional competencies with the purpose of achievement of the standard of professional education. The process of implementing these requirements is complicated by the diff erent approaches to FSS and professional standard. The study is based on a practical methodology that focuses on solving practical problems and purposeful transformation of vocational training programmes, to ensure integration of FSS and professional standards in the training of specialists. The article provides an example of integration of requirements of the FSS and professional standards on the basis of professional educational organizations.
The results consist in the description of the experience of the competence approach to organization of educational process, integration of standards by the example of one educational institution. This experience is applicable in any professional educational organization, regardless of the provisioning profile. The authors observed the diff erential nature of the main types of professional competencies of the FSS and the integrative nature of job functions of the professional standard, the necessity of designing professional modules having leading nature. The article describes the experience of integrating the standards applicable in any professional educational organization, regardless of the provisioning profile.