bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oil palm microfiber-reinforced handsheet-molded thermoplastic green composites for sustainable packaging applications
Authors: Hermawan D , Hazwan Che Mohamad , Owolabi FAT , Gopakumar Deepu A , Hasan M , Rizal Samsul , Sri Aprilla NA , Mohamed AR , Khalil HPS Abdul 
Published: July 2019

The forestry and agricultural market have been perceiving outstanding growth due to the advantages of green composites, such as cost effective in nature, environment friendly, excellent mechanical properties, and so on. Various researchers had studied the reinforcement efficiency of various natural fibers in the diverse polymer matrices. Herein, we reported the characterization of microfiber handsheet-molded thermoplastic green composites developed from the combination of oil palm empty fruit bunch (OPEFB)-based microfiber pulp as filler and polyester PP based as matrix. Refined alkaline extracted OPEFB pulp fiber was mixed at different layered composition of the composite of grafted polypropylene. The physical properties and mechanical properties were conducted according to the ASTM standard and showed substantial improvement of the handsheet-molded composite. The scanning electron microgram showed that, as the addition of OPEFB fiber loading increased, there was improved interfacial bonding except for 50% fiber loading which experience fiber pullout. The result also showed improved thermal stability compared with the neat composite. This study will be an effective platform to develop the packaging materials using polymer handsheet composite. [Formula: see text]
Sensitisation to staphylococcal enterotoxins and asthma severity: a longitudinal study in the EGEA cohort
Authors: Sintobin Ina , Siroux Valerie , Holtappels Gabriële , Pison Christophe , Nadif Rachel , Bousquet Jean , Bachert Claus 
Published: July 2019

IntroductionEvidence is accumulating thatStaphylococcus aureusplays an important role as disease modifier in upper and lower airway diseases. Sensitisation toS. aureusenterotoxins (SEs) was associated with an increased risk of severe asthma in previous cross-sectional studies, but evidence from longitudinal studies is lacking. We aimed to assess associations between SE-sensitisation and the subsequent risk for asthma severity and exacerbations.MethodsThis is a nested case–control study from the 20-year Epidemiological Study of the Genetics and Environment of Asthma (EGEA) cohort, including 225 adults (75 without asthma, 76 with mild asthma and 74 with severe asthma) in EGEA2 (2003–2007). For 173 of these individuals, SE-sensitisation was measured on samples collected 11 years earlier (EGEA1). Cross-sectional associations were conducted for EGEA1 and EGEA2. Longitudinal analyses estimated the association between SE-sensitisation in EGEA1 and the risk of severe asthma and asthma exacerbations assessed in the follow-up. Models were adjusted for sex, age, smoking, parental asthma/allergy and skin-prick test to house dust mite.ResultsSE-sensitisation varied between 39% in controls to 58% and 76% in mild and severe asthma, respectively, in EGEA1. An adjusted cross-sectional association showed that SE-sensitisation was associated with an increased risk of severe, but not for mild asthma. SE-sensitisation in EGEA1 was associated with severe asthma (adjusted OR 2.69, 95% CI 1.18–6.15) and asthma exacerbations (adjusted OR 4.59, 95% CI 1.40–15.07) assessed 10–20 years later.ConclusionFor the first time, this study shows that being sensitised to SEs is associated with an increased subsequent risk of severe asthma and asthma exacerbations.
Regulation of CD137 expression through K‐Ras signaling in pancreatic cancer cells
Authors: Glorieux Christophe , Huang Peng 
Published: July 2019

AbstractBackgroundThe interaction between CD137 and its ligand (CD137L) plays a major role in the regulation of immune functions and affects cancer immunotherapy. CD137 is a cell surface protein mainly located on activated T cells, and its regulation and functions in immune cells are well established. However, the expression of CD137 and its regulation in cancer cells remain poorly understood. The main purposes of this study were to examine the expression of CD137 in pancreatic cancer cells and to investigate its underlying mechanisms.MethodsCells containing inducible K‐RasG12V expression vector or with different K‐Ras mutational statuses were used as in vitro models to examine the regulation of CD137 expression by K‐Ras. Various molecular assays were employed to explore the regulatory mechanisms. Tumor specimens from 15 pancreatic cancer patients and serum samples from 10 patients and 10 healthy donors were used to test if the expression of CD137 could be validated in clinical samples.ResultsWe found that the CD137 protein was expressed on the cell surface in pancreatic cancer tissues and cancer cell lines. Enzyme‐linked immunosorbent assay revealed no difference in the levels of secreted CD137 in the sera of patients and healthy donors. By using the K‐Ras inducible cell system, we further showed that oncogenic K‐Ras up‐regulated CD137 through the activation of MAPK (mitogen‐activated protein kinases) and NF‐κB (nuclear factor kappa‐light‐chain‐enhancer of activated B cells) pathways, as evidenced by significantly reduced CD137 mRNA expression led by genetic silencing of MAPK1 and p65, the key proteins involved in the respective pathways. Furthermore, we also found that the NF‐κB pathway was mainly stimulated by the K‐Ras‐induced secretion of interleukin‐1α (IL‐1α) which promoted the transcription of the CD137 gene in pancreatic cancer cell lines. Analysis of the TCGA (the cancer genome atlas) database also revealed a significant correlation between IL‐1α and CD137 expression (r = 0.274) in tumor samples from pancreatic cancer patients (P < 0.001).ConclusionsThe present study has demonstrated that the CD137 protein was expressed on pancreatic cancer cell surface, and has identified a novel mechanism by which K‐Ras regulates CD137 in pancreatic cancer cells through MAPK and NF‐κB pathways stimulated by IL‐1α.
CAPE for measuring callous-unemotional traits in disadvantaged families: a cross-sectional validation study
Authors: Centifanti Luna C.M. , Shaw Hannah , Atherton Katherine J. , Thomson Nicholas D. , MacLellan Susanne , Frick Paul J. 
Published: July 2019

Background:Callous-unemotional (CU) traits are important for designating a distinct subgroup of children and adolescents with behaviour problems. As a result, CU traits are now used to form the specifier “with Limited Prosocial Emotions” that is part of the diagnostic criteria for the Conduct Disorder in the Diagnostic and Statistical Manual of Mental Disorders 5thEdition (DSM-5) and International Classification of Diseases 11thRevision (ICD-11). Given this inclusion in major classification systems, it is important to develop and test methods for assessing these traits that can be used in clinical settings. The present study aimed to validate a clinician rating of CU traits, the Clinical Assessment of Prosocial Emotions, Version 1.1 (CAPE 1.1), in a sample of hard-to-reach families referred to a government program designed to prevent the development of behaviour problems in high risk families.Methods:Clinical ratings of children were obtained from 34 families of children ages 3 to 19 (M=12.2; SD=4.3). The ratings on the CAPE 1.1 were based on interviews with both parent and child.Results:Of the sample, 21% (100% male) met the diagnostic cut-off for the specifier according to the CAPE 1.1, and CAPE 1.1 scores were associated with parent ratings of CU traits, psychopathic traits, and externalising behaviours. CAPE 1.1 ratings were also associated with risk for violence obtained from case files. Conclusions:These findings provide preliminary evidence for the validity of the CAPE 1.1 as clinician rated measure of CU traits.
A review on graphene-based polymer composite coatings for the corrosion protection of metals
Authors: Hussain Ahmed Khalid , Sudin Izman , Basheer Uday M. , Yusop Mohd Zamri Mohd 
Published: July 2019

Abstract
Graphene-based coating is an emerging field that focuses on developing advanced coatings by exploiting new generation materials with superior properties. Researchers are striving to develop coatings that are cost-effective, easy to prepare and highly effective by integrating graphene with a wide range of suitable materials for surface protection applications. In this critical review, different types of high performing graphene-based polymer composite coatings have been described for anticorrosion application. An in-depth survey on methods of preparation, coating application techniques and their influence on the corrosion behavior of coatings is presented briefly. Newly developed strategies to enhance the protection efficiency of graphene-polymer matrix coatings are also covered concisely. The authors hope that this review will assist prospective academicians and researchers in developing novel highly efficient graphene-based anticorrosion composite coatings for industrial applications.
Status Hukum dan Hak Anak Dari Perkawinan Wanita Hamil Dalam Perspektif Mazhab Syafi'i dan Hukum Positif
Authors: Rambe Mara Sutan 
Published: July 2019

Abstract.The legal status and rights of the child of the marriage of a pregnant woman according to the Shafi'i School are if the child is born less than six months from a legitimate marriage or the possibility of prior bodily relationships, then the child is an illegitimate child and only has a relationship to his mother and family her mother. However, if the child is born more than six months of pregnancy from a legal marriage or if there is a possible relationship, then the child is a legitimate child, so he has rights to his parents. UUP and KHI regulate that children born from the marriage of pregnant women due to zina are legitimate children, as long as the child is born from a legitimate marriage (article 42 UUP and article 99 points a KHI), so that he has rights that must be fulfilled by both her parents. However, if a child born due to adultery is not in a legal marriage, then the child only has a civil relationship to his mother as stated in article 43 (1) of the LoGA. However Article 43 (1) has a Judicial Review, so that a child born outside of marriage does not only have a civil relationship with his mother but also has a civil relationship with his biological father.Keywords: Legal Status, Children's Rights, Marriage of Pregnant Women Abstrak.Status hukum dan hak anak dari perkawinan wanita hamil menurut Mazhab Syafi’i adalah jika anak tersebut lahir kurang dari enam bulan dari perkawinan yang sah atau dimungkinkan adanya hubungan badan sebelumnya, maka anak tersebut adalah anak tidak sah dan hanya mempunyai hubungan nasab kepada ibunya dan keluarga ibunya. Namun, jika anak tersebut lahir lebih dari enam bulan masa kehamilan dari perkawinan sah atau dimungkinkan adanya hubungan badan, maka anak tersebut adalah anak sah, sehingga memiliki hak terhadap kedua orang tuanya. UUP dan KHI bahwa anak yang lahir dari perkawinan wanita hamil akibat zina adalah anak yang sah, sepanjang anak tersebut lahir dari perkawinan yang sah (pasal 42 UUP dan pasal 99 poin a KHI), sehingga ia memiliki hak-hak yang wajib dipenuhi oleh kedua orang tuanya. Namun jika anak yang lahir akibat zina tidak dalam ikatan perkawinan yang sah, maka anak tersebut hanya mempunyai hubungan perdata kepada ibunya saja sebagaimana yang tercantum dalam pasal 43 (1) UUPA. Namun Pasal 43 (1) ini telah Judicial riview, sehingga anak yang dilahirkan di luar perkawinan tidak hanya mempunyai hubungan perdata dengan ibunya tetapi juga mempunyai hubungan perdata kepada ayah biologisnya.Kata Kunci: Status Hukum, Hak Anak, Perkawinan Wanita Hamil
Pendidikan Kampus Sebagai Media Penanaman Nilai-nilai Antikorupsi Bagi Mahasiswa
Authors: Hidayat Asep Syarifuddin 
Published: July 2019

Abstract.Corruption has been happening for a long time in Indonesia. The practice of abuse of authority, bribery, giving facilitation payments, illegal fees, giving rewards on the basis of collusion and nepotism as well as the use of state money for personal interests, are interpreted as acts of corruption and are considered as common things in this country. Ironically, nowadays there is a lot of corruption that occurs not only among officials but also in small communities. Although efforts to eradicate it have been carried out for more than four decades, however, these corrupt practices continue, there is even a tendency for the modus operandi to be more sophisticated and organized, making it even more difficult to overcome.Keywords: Anti-corruption Education, KPK, Community Culture Abstrak.Korupsi telah terjadi sejak lama di Indonesia. Praktik penyalahgunaan wewenang, penyuapan, pemberian uang pelicin, pungutan liar, pemberian imbalan atas dasar kolusi dan nepotisme serta penggunaan uang negara untuk kepentingan pribadi, oleh masyarakat diartikan sebagai suatu perbuatan korupsi dan dianggap sebagai hal yang lazim terjadi di negara ini. Ironisnya, saat ini banyak korupsi yang terjadi bukan hanya pada kalangan pejabat saja tetapi pada kalangan masyarakat kecil. Walaupun usaha-usaha pemberantasannya sudah dilakukan lebih dari empat dekade, namun, praktik-praktik korupsi tersebut tetap berlangsung, bahkan ada kecenderungan modus operandinya lebih canggih dan terorganisir, sehingga makin mempersulit penanggulangannya.Kata Kunci: Pendidikan Antikorupsi, KPK, Budaya Masyarakat
Konstruksi Relasi Dakwah di Pondok Pesantren Sindangsari Al-Jawami
Authors: Aliman Muhamad 
Published: July 2019

The purpose of this research is to develop, understand and analyze Kyai with students, especially in the life of the boarding school "Al-Jawami Sindangsari". This study is expected to be a study that enriches thought and data on broadcasting communications perspective of Islam. This study uses a qualitative methodology with the method of phenomenology of perception, which is supported by the data collection techniques with behavioral observation. Phenomenology is used to understand how a person experiences and give meaning to a perception. The world's perception of the research made the lives of people, their subjective experience of the everyday personal life. So the pure truth of a statement from the object of research. The results of this study in the form of construction clerics with students at boarding school Sindangsari Al-Jawami formed from the intensity of perception, high interaction between clerics with students, students with students and identities performance clerics with students, where the chaplain serves as a party that is able to connect the message clerics to students in the form of verbal and nonverbal. AbstrakTujuan dari penelitian ini adalah untuk menyusun, memahami dan menganalisis Kyai dengan santri, khususnya pada kehidupan pondok pesantren “Sindangsari Al-Jawami”. Penelitian ini diharapkan menjadi sebuah kajian yang memperkaya pemikiran dan data mengenai perspektif komunikasi penyiaran Islam. Penelitian ini menggunakan metodologi kualitatif dengan metode fenomenologi persepsi, yang didukung dengan teknik pengumpulan data dengan pengamatan perilaku. Fenomenologi digunakan untuk memahami bagaimana seseorang mengalami dan memberi makna pada sebuah persepsi. Persepsi dijadikan riset terhadap dunia kehidupan orang-orang, pengalaman subjektif mereka terhadap kehidupan pribadi sehari-hari. Jadi kebenaran murni berasal dari statement obyek penelitian. Hasil penelitian ini berupa konstruksi kyai dengan santri di Pondok Pesantren Sindangsari Al-Jawami yang terbentuk dari intensitas persepsi, interaksi yang tinggi antara kyai dengan santri, santri dengan santri dan identitas performance kyai dengan santri, dimana ustadz berfungsi sebagai pihak yang mampu menyambungkan pesan kyai kepada santri baik dalam bentuk verbal maupun nonverbal.
Hepatozoonose Canina: Relato de Caso
Authors: Santos Camila Maria dos , Halverson Maristela Martins de Souza , Oliveira Fabiana Pessoa Salgado de 
Published: July 2019

A hepatozoonose é uma hemoparasitose descrita no Brasil pela primeira vez, em 1979, e relatada com maior frequência nos últimos anos. O agente causador da infecção é um protozoário do gênero Hepatozoon sp., sendo Hepatozoon canis a espécie que mais acomete cães domésticos brasileiros. O cão se infecta com H. canis após a ingestão de carrapatos infectados com oocistos esporulados do protozoário. A doença não apresenta sintomatologia específica, mas pode ocorrer coinfecções com outras hemoparasitose o que pode dificultar ou até mesmo agravar o diagnóstico clínico da doença. A presença de isogametas em células polimorfonucleares no esfregaço sanguíneo de cães ainda é muito utilizada, apesar de sua baixa sensibilidade. Testes moleculares podem revelar a verdadeira realidade da doença no país e seu uso vem sendo utilizado como forma de diagnóstico para a rotina veterinária. A associação de Doxiciclina com Dipropionato de Imidocarb tem sido considerada eficaz no tratamento de hepatozoonose. O presente trabalho tem por objetivo relatar a ocorrência de hepatozoonose em uma fêmea canina adulta, atendida no Hospital Veterinário da Universidade Uniderp, com diagnóstico de hérnia perineal. Palavras chave: Hemoparasitose. Esfregaço. Doença. AbstractHepatozoonosis is a hemoparasthosis described in Brazil for the first time in 1979 and reported more frequently in recent years. The agent that causes the infection is a protozoan of the genus Hepatozoon sp, being Hepatozoon canis the species that most affects Brazilian domestic dogs. The dog becomes infected with H. canis after ingestion of ticks infected with sporulated protozoan oocysts. The disease does not present specific symptoms, but coinfections with other hemoparasites may occur, which may hinder or even aggravate the disease clinical diagnosis. The presence of isogamates in polymorphonuclear cells in the dogs’ blood smear is still widely used, despite its low sensitivity. Molecular tests may reveal the true reality of the disease in the country and its use has been used as a diagnostic form for the veterinary routine. The association of Doxycycline with Imidocarb Dipropionate has been considered effective in the hepatozoonosis treatment. The present study aims to report the occurrence of hepatozoonosis in an adult female canine, attended at the Veterinary Hospital of Uniderp University, with diagnosis of perineal hernia. Keywords: Hemoparasitosis. Smear. Disease
The Effects of Music Therapy on Vital Signs and Dental Anxiety Prior to Dental Surgery
Authors: KOCAMAN Gulhan , Cetin Benli Neriman 
Published: July 2019

Objective: To investigate the effects of music therapy on vital signs and dental anxiety prior periodontal surgery.Methods Having received their informed consents prior to surgery, in the scope of this study, a questionnaire including Corah Dental Anxiety Scale was applied to 35 patients admitted to Oral and Dental Health Centre’s Periodontology Clinic for periodontal surgery. Vital signs and mouth opening measurements including blood pressure, pulse and respiration were performed. Then the music therapy was performed. In the application of music therapy, the patients were asked to take the position they feel most comfortable in, couchant or seated, and close their eyes while the setting was kept quiet. With headphones, they were exposed to the soothing sound of water and reed flute. After the application, vital signs and mouth opening measurement were re-evaluated. Results : In our study, 68.8% of the patients stated that dental treatment was not fearful, but the rate of dental anxiety before dental surgery was found to be 85.7%. It was found that systolic blood pressure, diastolic blood pressure, pulse and mouth opening measurements of the patients were significantly affected (p &lt;0.05) and no statistically significant changes were observed in the respiratory system.Conclusion The music therapy performed before periodontal surgery was found to be a cost-effective, painless, non-adverse non-pharmacological sedative and anxiolytic on vital signs and mouth opening.
Opióides na Dor Oncológica e o seu Uso em Circunstâncias Particulares: Uma Revisão Narrativa
Authors: Vieira Cláudia , Brás Marta , Fragoso Maria 
Published: July 2019

Introdução: A dor é equiparada a quinto sinal vital e deve ser avaliada de forma sistemática em todas as consultas de um paciente com cancro. Os fármacos utilizados na prática oncológica para tratar os doentes com dor crónica moderada a severa incluem analgésicos de ação periférica e central que têm sido abordados em múltiplas diretrizes nacionais e internacionais. No entanto, na prática clínica há que equacionar outros problemas e eventuais comorbilidades, que podem levantar dúvidas no momento da prescrição.Material e Métodos: Fez-se uma revisão da literatura, tentando refletir sobre algumas situações específicas na utilização de opióides, nomeadamente perda da via oral, insuficiência renal (hemodiálise), insuficiência hepática, interações medicamentosas e formulações de ação imediata.Resultados: Os opiáceos naturais (morfina e codeína) e os seus derivados sintéticos e semissintéticos (hidromorfona, oxicodona, fentanilo), o agonista parcial buprenorfina e finalmente o tramadol e tapentadol foram selecionados para esta análise. Os sistemas transdérmicos estão apenas disponíveis para a buprenorfina e o fentanilo. Na insuficiência hepática, o fentanilo foi considerado seguro, mascom exceção da codeína e do tramadol, podem todos ser usados com precaução. Na insuficiência renal, o fentanilo, a hidromorfona e o tapentadol foram considerados seguros. Deve evitar-se a morfina, e os restantes poderão ser usados com precaução. Em pacientes em hemodiálise pode usar-se buprenorfina, fentanilo, hidromorfona e tramadol (em doses até 200 mg/dia).Discussão: O não reconhecimento do impacto das várias situações descritas ao longo deste trabalho, nomeadamente a alteração da biodisponibilidade por perda de via oral, por alteração da farmacocinética e farmacodinâmica dos vários fármacos, quer no contexto da insuficiência de órgão responsável pelo metabolismo ou excreção, quer no contexto das interações farmacológicas, condiciona umnorme risco de subtratamento da dor e consequente impacto em termos de qualidade de vida.Conclusão: A prescrição de opióides é segura e efetiva, mesmo em situações de comorbilidades moderadas a graves como insuficiência renal e hepática e em doentes sem via oral disponível. Neste caso, como quando considerámos as interações farmacológicas, o plano terapêutico deve ser individualizado e o paciente deve ser avaliado regularmente. A seleção inadequada e/ou dose mal ajustada de um fármaco, o não reconhecimento do impacto dos efeitos adversos, frequentemente justificam o mau controlo da dor e a toxicidade excessiva.