bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review Article on Internet-based Psychological Interventions in Primary Care. What is the Global Experience? How Reliable are Results from RCTs? Lessons Learned from the European, US and Australian Case Studies
Authors: Sogomonjan Melita , Kerikmäe Tanel , Ööpik Pille 
Published: January 2019

Abstract
In the context of the EU’s Digital Single Market (eHealth) Strategy, the deployment of digital tools for patients’ empowerment and person-centred care is of high demand and importance. Shifting from treatment to health promotion and disease prevention, a variety of internet-based cognitive behavioural therapy programmes have been proven to be effective for managing common mental health disorders in secondary care even hough the effectiveness and the clinical use of internet-based cognitive behavioural therapy programmes alone in primary care have not been approved yet. Additionally, such interventions are neither included in the international clinical guidelines for treating common mental health disorders nor regulated by Member States as a healthcare service. Despite that, the UK National Health Service and the Swedish National Board of Health and Welfare endorse the use of internet-based cognitive behavioural therapy as a first treatment option. The aim of this research is to investigate the global experience of internet-based cognitive behavioural therapy programmes in controlled and real-life conditions in general practice and to evaluate the reliability of the results and concomitantly their compliance with the European Commission’s eHealth Strategy. A systematic review of quantitative studies was conducted from January 2007 to December 2017. The results indicated that unsupported internet-based cognitive behavioural therapy programmes alone are less effective than combined therapy options for treatment purposes, if no additional therapy is prescribed. Guided internet-based cognitive behavioural therapy may supplement traditional treatment methods resulting in improving the control of mental disorders, but are unable to demonstrate consistent quality or replace face-to-face therapy.
A gluing approach for the fractional Yamabe problem with isolated singularities
Authors: Ao Weiwei , DelaTorre Azahara , González María del Mar , Wei Juncheng 
Published: January 2019

Abstract
We construct solutions for the fractional Yamabe problem that are singular at a prescribed number of isolated points. This seems to be the first time that a gluing method is successfully applied to a non-local problem in order to construct singular solutions. There are two main steps in the proof: to construct an approximate solution by gluing half bubble towers at each singular point, and then an infinite-dimensional Lyapunov–Schmidt reduction method, that reduces the problem to an (infinite-dimensional) Toda-type system. The main technical part is the estimate of the interactions between different bubbles in the bubble towers.
Predicting Aggregated User Satisfaction in Software Projects
Authors: Radliński Łukasz 
Published: January 2019

Abstract
User satisfaction is an important feature of software quality. However, it was rarely studied in software engineering literature. By enhancing earlier research this paper focuses on predicting user satisfaction with machine learning techniques using software development data from an extended ISBSG dataset. This study involved building, evaluating and comparing a total of 15,600 prediction schemes. Each scheme consists of a different combination of its components: manual feature preselection, handling missing values, outlier elimination, value normalization, automated feature selection, and a classifier. The research procedure involved a 10-fold cross-validation and separate testing, both repeated 10 times, to train and to evaluate each prediction scheme. Achieved level of accuracy for best performing schemes expressed by Matthews correlation coefficient was about 0.5 in the cross-validation and about 0.5–0.6 in the testing stage. The study identified the most accurate settings for components of prediction schemes.
Investigations into Flour Mixes of Triticum Monococcum and Triticum Spelta
Authors: Kóczán-Manninger Katalin , Badak-Kerti Katalin 
Published: January 2019

Abstract
Bread samples were made using flour mixes of Triticum monococcum (Tr. monococcum) and Triticum spelta (Tr. spelta). They were tested for their rheological behaviour over the first 3 days of storage at room temperature, and for their characteristics based on a Hungarian Standard. Parameters were set such as the volume of the baked product, baking loss, crumb characteristics and elasticity of crumbs. The behaviour of flour from einkorn wheat is different to that of Tr. spelta. The properties of the tested flour mixes measured by a farinograph show that Tr. spelta produces an acceptable dough, on the other hand, the dough of Tr. monococcum develops quickly but is very unstable so weakens within minutes of being kneaded. This also suggests that doughs composed of einkorn wheat flour require a different type of kneading than those of Tr. spelta (or Tr. aestivum, also referred to as common wheat) flours. Breads composed of Tr. spelta were comparable with those made with Tr. aestivum, the crumb elasticity was above 90 % on the day of baking, which indicates high quality. The Tr. monococcum breads, however, were of low grade: the volume of the breads decreased by increasing the ratio of Tr. monococcum to Tr. spelta and the elasticity reduced to unacceptable levels (less than 60 %). It should be mentioned that the grading was based on breads made purely from Tr. aestivum flours.
Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature
Authors: Saik Olga V. , Demenkov Pavel S. , Ivanisenko Timofey V. , Bragina Elena Yu. , Freidin Maxim B. , Dosenko Victor E. , Zolotareva Olga I. , Choynzonov Evgeniy L. , Hofestaedt Ralf , Ivanisenko Vladimir A. 
Published: January 2019

Abstract
Comorbid states of diseases significantly complicate diagnosis and treatment. Molecular mechanisms of comorbid states of asthma and hypertension are still poorly understood. Prioritization is a way for identifying genes involved in complex phenotypic traits. Existing methods of prioritization consider genetic, expression and evolutionary data, molecular-genetic networks and other. In the case of molecular-genetic networks, as a rule, protein-protein interactions and KEGG networks are used. ANDSystem allows reconstructing associative gene networks, which include more than 20 types of interactions, including protein-protein interactions, expression regulation, transport, catalysis, etc. In this work, a set of genes has been prioritized to find genes potentially involved in asthma and hypertension comorbidity. The prioritization was carried out using well-known methods (ToppGene and Endeavor) and a cross-talk centrality criterion, calculated by analysis of associative gene networks from ANDSystem. The identified genes, including IL1A, CD40LG, STAT3, IL15, FAS, APP, TLR2, C3, IL13 and CXCL10, may be involved in the molecular mechanisms of comorbid asthma/hypertension. An analysis of the dynamics of the frequency of mentioning the most priority genes in scientific publications revealed that the top 100 priority genes are significantly enriched with genes with increased positive dynamics, which may be a positive sign for further studies of these genes.
Majorization, “useful” Csiszár divergence and “useful” Zipf-Mandelbrot law
Authors: Latif Naveed , Pečarić Đilda , Pečarić Josip 
Published: January 2019

AbstractIn this paper, we consider the definition of “useful” Csiszár divergence and “useful” Zipf-Mandelbrot law associated with the real utility distribution to give the results for majorizatioQn inequalities by using monotonic sequences. We obtain the equivalent statements between continuous convex functions and Green functions via majorization inequalities, “useful” Csiszár functional and “useful” Zipf-Mandelbrot law. By considering “useful” Csiszár divergence in the integral case, we give the results for integral majorization inequality. Towards the end, some applications are given.
Pretty good state transfer on 1-sum of star graphs
Authors: Hou Hailong , Gu Rui , Tong Mengdi 
Published: January 2019

AbstractLetAbe the adjacency matrix of a graphGand supposeU(t) = exp(itA). We say that we have perfect state transfer inGfrom the vertexuto the vertexvat timetif there is a scalarγof unit modulus such thatU(t)eu=γ ev. It is known that perfect state transfer is rare. So C.Godsil gave a relaxation of this definition: we say that we have pretty good state transfer fromutovif there exists a complex numberγof unit modulus and, for each positive realϵthere is a timetsuch that ‖U(t)eu–γ ev‖ <ϵ. In this paper, the quantum state transfer on 1-sum of star graphsFk,lis explored. We show that there is no perfect state transfer onFk,l, but there is pretty good state transfer onFk,lif and only ifk=l.
Common fixed point theorem of six self-mappings in Menger spaces using (CLRST) property
Authors: Liu Xiao-lan , Zhou Mi , Mishra Lakshmi Narayan , Mishra Vishnu Narayan , Damjanović Boško 
Published: January 2019

AbstractIn this paper, we study the existence and uniqueness of common fixed point of six self-mappings in Menger spaces by using the common limit range property (denoted by (CLRST)) of two pairs. Our results improve, extend, complement and generalize several existing results in the literature. Also, some examples are provided to illustrate the usability of our results.
Study on the chemical constituents of Dacrydium elatum and their cytotoxic activity
Authors: Thao Tran Thi Phuong , Lieu Nguyen Thi , Ninh Pham Thi , Chien Tran Van , Phong Dinh Thi , Loc Tran Van , Sung Tran Van 
Published: January 2019

Abstract
From an ethyl acetate extract of twigs and barks of Dacrydium elatum a new diterpenoid named dacrydianone (1), together with lambertic acid (2), three ecdysteroids: 20-hydroxyecdysone (3), ajugasterone C (4), ponasterone A (5), and daucosterol (6), has been isolated. Their structures were elucidated by an extensive analysis of the UV/Vis, FT-IR, MS and NMR spectra as well as comparison with those in published literature. The EtOAc extract and the isolated compounds 1–5 were evaluated for their cytotoxicity on four cancer cell lines: breast cancer (MCF-7), lung cancer (Lu-1), liver cancer (HepG2) and human oral cancer (KB). The EtOAc extract and compound 2 showed a medium activity on four tested cancer cell lines, while compounds 3 and 5 exhibited week activity on these cell lines. Compounds 1 and 4 did not show activity on the tested cell lines.
Developments in Flame-Retardant Bio-composite Material Production
Authors: Anannya Ferdausee Rahman , Mahmud Md. Arif 
Published: January 2019

Abstract
Flame-retardant composites have been researched for more than four decades, and demands are on the rise for this type of product in various applications. Since bio-composites have become popular these days, researchers have turned their attention to producing flame-retardant bio-composites. The main advantage of the bio-composite is its easy degradation process by naturally occurring bio-components. These types of composites can be partially biodegradable or fully biodegradable, and the rate of the degradability depends on the contents of the material. Partially biodegradable ones generally contain natural fiber as a reinforcement, along with a nonbiodegradable synthetic resin, while fully biodegradable ones contain either only biopolymers or a blend of natural fiber and biopolymer. Generally, flame-retardant bio-composites contain an additional flame-retardant filler material as well. This article will try to review the studies that have taken place on developing flame-retardant bio-composites and try to point out some key factors by which the properties of the end product may be controlled, so that the end products of the desired properties can be produced in further research.
Effects of Central Opening in Masonry Infill on Lateral Behavior of Intermediate RC Frames
Authors: Ahani Elshan , Mousavi Mir Naghi , Rafezy Behzad , Osmanzadeh Fathollah 
Published: January 2019

Abstract
Despite not being taken into account in structural modeling, the complex behavior of masonry affects the seismic performance of structures. The main aim of this study is to evaluate the effects of infilled frames with different percentages of openings on reinforced concrete (RC) moment frames. Initially, an experimental model was constructed and subjected to loading. Afterwards, corresponding numerical analyses were carried out based on the experimental model. A simplified micromodeling method with respect to the numerical simulation of the experimental model was assigned. Subsequently, sensitivity analyses were performed to investigate the effects of the opening ratio on the behavior of intermediate RC moment frames. The analytical results indicate that increasing the percentage of the opening leads to a significant reduction in the lateral strength of the frame. The lateral strength of the masonry wall was negligible in masonry infills with openings greater than 40 %. While prognosticating the behavior of buildings with masonry walls is complicated, determining the behavior of infilled frames with different percentages of openings will make it much easier to predict the damage pattern.
Self-Report Versus Informant Responses: Exploring the Relationship between Excessive Reassurance Seeking and Depression
Authors: Anagnostopoulos Vasiliki , Carter Michele M. 
Published: January 2019

Introduction: This study expanded on prior research exploring the relationship between excessive reassurance seeking (ERS) and depression by conducting a longitudinal study evaluating two reporting sources (participants and informants). The current research was also the first to examine a sequential mediation model, with interpersonal competence as an antecedent in this relationship. Method: One hundred and ten participants completed measures at two time-points separated by five weeks. Corresponding informants completed comparable measures at participants' Time 2. Results: Results revealed differences based on reporting source, with more significant correlations found among participant- as compared to informant-reported variables. Moreover, findings supported interpersonal competence as an antecedent to the ERS-depression relationship. Finally, this research highlighted the role of brooding, in addition to ERS, in the development of depressive symptoms. Discussion: This study offers support for further consideration of methodology on outcomes, underlines the role of interpersonal competence as a precursor to depression, and encourages clinicians to target both brooding and ERS behavior in the treatment and prevention of depression.
Allelic Variation in the Toll-Like Receptor Adaptor ProteinTicam2Contributes to SARS-Coronavirus Pathogenesis in Mice
Authors: Gralinski Lisa E , Menachery Vineet D , Morgan Andrew P , Totura Allison L , Beall Anne , Kocher Jacob , Plante Jessica , Harrison-Shostak D Corinne , Schäfer Alexandra , Pardo-Manuel de Villena Fernando , Ferris Martin T , Baric Ralph S 
Published: January 2019

AbstractHost genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from the Collaborative Cross mouse multi-parent population, we identified two lines showing highly divergent susceptibilities to SARS-CoV: the resistant CC003/Unc and the susceptible CC053/Unc. We generated 264 F2 mice between these strains, and infected them with SARS-CoV. Weight loss, pulmonary hemorrhage, and viral load were all highly correlated disease phenotypes. We identified a quantitative trait locus of major effect on chromosome 18 (27.1–58.6 Mb) which affected weight loss, viral titer and hemorrhage. Additionally, each of these three phenotypes had distinct quantitative trait loci [Chr 9 (weight loss), Chrs 7 and 12 (virus titer), and Chr 15 (hemorrhage)]. We identified Ticam2, an adaptor protein in the TLR signaling pathways, as a candidate driving differential disease at the Chr 18 locus. Ticam2−/− mice were highly susceptible to SARS-CoV infection, exhibiting increased weight loss and more pulmonary hemorrhage than control mice. These results indicate a critical role for Ticam2 in SARS-CoV disease, and highlight the importance of host genetic variation in disease responses.
Selective Sweeps
Authors: Stephan Wolfgang 
Published: January 2019

AbstractFor almost 20 years, many inference methods have been developed to detect selective sweeps and localize the targets of directional selection in the genome. These methods are based on population genetic models that describe the effect of a beneficial allele (e.g., a new mutation) on linked neutral variation (driven by directional selection from a single copy to fixation). Here, I discuss these models, ranging from selective sweeps in a panmictic population of constant size to evolutionary traffic when simultaneous sweeps at multiple loci interfere, and emphasize the important role of demography and population structure in data analysis. In the past 10 years, soft sweeps that may arise after an environmental change from directional selection on standing variation have become a focus of population genetic research. In contrast to selective sweeps, they are caused by beneficial alleles that were neutrally segregating in a population before the environmental change or were present at a mutation-selection balance in appreciable frequency.
Barbara J. Meyer: 2018 Thomas Hunt Morgan Medal
Authors: Haloupek Nicole 
Published: January 2019

Abstract
The Genetics Society of America’s (GSA) Thomas Hunt Morgan Medal honors researchers for lifetime achievement in genetics. The recipient of the 2018 Morgan Medal, Barbara J. Meyer of the Howard Hughes Medical Institute and the University of California, Berkeley, is recognized for her career-long, groundbreaking investigations of how chromosome behaviors are controlled. Meyer’s work has revealed mechanisms of sex determination and dosage compensation in Caenorhabditis elegans that continue to serve as the foundation of diverse areas of study on chromosome structure and function today, nearly 40 years after she began her work on the topic.
KAMU HARCAMALARI VE EKONOMİK BÜYÜME ARASINDAKİ İLİŞKİ: G7 ÜLKELERİ İÇİN PANEL VERİ ANALİZİ
Authors: Ökde Burak , Bülbül Duran 
Published: January 2019

Kamu
harcamalarının azaltılarak ekonomi içinde devletin rolünün mümkün olan en az
seviyede tutulması gerekliliği, günümüz ekonomik çevrelerinde yaygın olarak
savunulmaktadır. Kamu harcamalarının azaltılmasıyla ekonomideki vergi yükünün
de azalacağı belirtilmektedir. Bu durumda, ekonomik kaynakların daha üretken
özel sektör tarafından kullanılacağı savunulmaktadır. Bunun sonucunda ise daha
hızlı bir ekonomik büyümenin gerçekleştirileceği düşünülmektedir. Keynesyen
politikaları savunan iktisatçılar, kamu harcamaları yoluyla ekonomik büyümenin
sağlanabileceğini savunmaktadırlar. Bu görüşü desteklemeyenler ise kamu kesiminin
kaynakları verimsiz kullanacağını ileri sürmektedirler. Buna ek olarak, hükümetlerin seçim kaygısıyla uzun vadeli
yatırımlar yerine oy oranını artıracak cari harcamalara daha yatkın olduğunu
belirtmektedirler.

Bu
çalışmada, 1990-2016 yılları arası, ekonomik büyüme ve kamu harcamaları yıllık
verileri kullanılarak, G7 ülkelerinde ekonomik büyüme ve kamu harcamaları
arasındaki ilişki incelenmiştir. Çalışmada, serilerin durağanlığı CADF birim
kök testi ile araştırılmıştır. Panel eşbütünleşme ilişkisi yatay kesit
bağımlılığını dikkate alan Westerlund-Edgerton (2007) eşbütünleşme testiyle
incelenmiştir. Uzun dönem eşbütünleşme katsayıları ise AMG yöntemiyle
belirlenmiştir. Çalışma sonucuna göre kamu harcamalarında meydana gelen artışın
ekonomik büyümeyi artırdığı tespit edilmiştir.
BABILDAMA DÖNEMİNDE OKUMA TAKLİDİ
Authors: Tarcan Ahmet 
Published: January 2019

Bebek vokalizasyonlarının
ilk aylardaki yapı taşları ünlü seslerdir. Bu ses blokları 6. ay civarlarında
olgunlaşarak bir ünsüz ve ünlüden oluşan (C1V1C1V1) ses zincirlerine
dönüşmektedir. Yaklaşık 12.ayda ise, ilk sözcükle eşzamanlı olarak farklı
ünsüzler aynı ses dizisinde (C1V1C2V2) birlikte yer almaktadır. Bu evre
literatürde çeşitlenmiş, çok tipli babıldama (İng.Jargon babbling, fr.
babillage varié-) şeklinde adlandırılmaktadır.

Çok tipli babıldama
evresinde çıkarılan ses zincirleri değerlendirildiğinde, bunların özellik ve
işlev açısından kendi aralarında farklılaştıkları, tek tip homojen bir yapının
söz konusu olmadığı dikkat çekmektedir. Bebek bağlama göre (tek başına iken,
televizyon izlerken ya da bir kitabın sayfalarını çevirirken) farklı
vokalizasyonlar çıkarabilmektedir. Bu
çalışmada dil öncesi dönemde, özellikle çeşitlenmiş babıldama evresinde bir
“okuma taklidinin” söz konusu olduğu vurgulanmış ve bu özel “okuma
vokalizasyonu”’nun özellikleri araştırılarak, yapı ve işlev açısından diğer
rutin babıldama türlerinden farklılaşıp farklılaşmadığı sorgulanmıştır.

Araştırma sonucunda
hece türü oranları ve ses özellikleri (tonlama, ezgi) açısından “okuma
taklidinin” diğer rutin babıldamadan farklı özellikler taşıdığı sonucuna
ulaşılmıştır.
Current View on the Postoperative Asthenopic Syndrome Problem in Patients with Corneal Refractive Surgery. Review
Authors: Mushkova I. A. , Maychuk N. V. , Markova E. Yu. , Shamsetdinova L. T. 
Published: January 2019

Laser technologies of corneal surgery perfection was one of the important events in ophthalmology in the past decades. Despite to the significant success in refractive surgery and the achieved high result in visual acuity, the ideal healing of the cornea, the absence of dry eye syndrome, some patients in the postoperative period present asthenopic complaints. Patients may notice a decrease in visual acuity when working near, difficulty in refocusing from far to near distance, fuzzy, blurred images, red eyes, tearing, periodic or permanent diplopia at different distances in the postoperative period. Adaptation to emmetropic refraction in these patients can cause discomfort, headache and visual fatigue even with insignificant visual loads, which leads to the development of asthenopia and worsening of their subjective status. Corneal refractive surgery leads to changes in the anatomical and optic parameters of the eye, which contributes to the formation of new accommodation-convergence interactions. If the accommodative and binocular functions were disrupted preoperatively, there is a risk of decompensation and development of postoperative asthenopic syndrome (AS). Refractive surgery, saving patients from glasses and contact lenses, can not completely eliminate their existing imbalances between accommodation and convergence. This can be explained with the fact that the existence of a formed pathological system does not cease with the elimination of the etiologic factor. In order to correct the disturbed parameters, additional research methods and effective methods of functional treatment of patients in the postoperative period were suggested. However, most of them are aimed at pathogenetic effects on accommodative muscles, often without taking into account disturbances in the oculomotor apparatus and binocular function. Thus, existing algorithms for investigating and managing patients with refractive disorders do not allow us to identify predictors for the development of asthenopia before refractive surgery, there is no set of preventive restoration measures aimed at restoring accommodative capacity and binocular interaction in the preoperative period to increase satisfaction with the results of surgery in patients at risk of postoperative AS.