bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis
Authors: Kwok Alastair , Dordevic Aimee L. , Paton Gemma , Page Matthew J. , Truby Helen 
Published: January 2019

AbstractThe relationship between alcohol consumption and body weight is complex and inconclusive being potentially mediated by alcohol type, habitual consumption levels and sex differences. Heavy and regular alcohol consumption has been positively correlated with increasing body weight, although it is unclear whether this is due to alcohol consumption per se or to additional energy intake from food. This review explores the effects of alcohol consumption on food energy intake in healthy adults. CINAHL Plus, EMBASE, Medline and PsycINFO were searched through February 2018 for crossover and randomised controlled trials where an alcohol dose was compared with a non-alcohol condition. Study quality was assessed using the Effective Public Health Practice Project tool. A total of twenty-two studies involving 701 participants were included from the 18 427 papers retrieved. Studies consistently demonstrated no compensation for alcoholic beverage energy intake, with dietary energy intake not decreasing due to alcoholic beverage ingestion. Meta-analyses using the random-effects model were conducted on twelve studies and demonstrated that alcoholic beverage consumption significantly increased food energy intake and total energy intake compared with a non-alcoholic comparator by weighted mean differences of 343 (95 % CI 161, 525) and 1072 (95 % CI 820, 1323) kJ, respectively. Generalisability is limited to younger adults (18–37 years), and meta-analyses for some outcomes had substantial statistical heterogeneity or evidence of small-study effects. This review suggests that adults do not compensate appropriately for alcohol energy by eating less, and a relatively modest alcohol dose may lead to an increase in food consumption.
The Circle Transfer and Cobordism Categories
Authors: Giansiracusa Jeffrey 
Published: January 2019

AbstractThe circle transfer $Q\Sigma (LX_{hS^1})_+ \to QLX_+$ has appeared in several contexts in topology. In this note, we observe that this map admits a geometric re-interpretation as a morphism of cobordism categories of 0-manifolds and 1-cobordisms. Let 𝒞1(X) denote the one-dimensional cobordism category and let Circ(X) ⊂ 𝒞1(X) denote the subcategory whose objects are disjoint unions of unparametrized circles. Multiplication in S1 induces a functor Circ(X) → Circ(LX), and the composition of this functor with the inclusion of Circ(LX) into 𝒞1(LX) is homotopic to the circle transfer. As a corollary, we describe the inclusion of the subcategory of cylinders into the two-dimensional cobordism category 𝒞2(X) and find that it is null-homotopic when X is a point.
Survival and energy use ofIxodes scapularisnymphs throughout their overwintering period
Authors: Burtis James C. , Fahey Timothy J. , Yavitt Joseph B. 
Published: January 2019

AbstractThe blacklegged tick (Ixodes scapularis) spends up to 10 months in the soil between feeding as larvae and questing for hosts as nymphs the following year. We tracked the survival and energy use of 4320 engorged larvae evenly divided across 288 microcosms under field conditions from September to July on sites with high (>12 nymphs/150 m2) and low (<1.2 nymphs/150 m2) densities of naturally questingI. scapularisin New York State. Subsets of microcosms were destructively sampled periodically during this period to determine tick survivorship and physiological age. Across all sites tick mortality was low during the winter and increased in the spring and early summer, coincident with increasing energy use. Neither energy use nor mortality differed significantly between sites with highvslow natural tick density, but we did observe a significant positive relationship between soil organic matter content and the survival ofI. scapularisduring the spring. Our results suggest that the off-host mortality and energy use ofI. scapularisnymphs is relatively low in the winter and increases significantly in the spring and early summer.
Malaria infection status of European Robins seems to associate with timing of autumn migration but not with actual condition
Authors: Ágh Nóra , Piross Imre Sándor , Majoros Gábor , Csörgő Tibor , Szöllősi Eszter 
Published: January 2019

AbstractAvian malaria parasites can negatively affect many aspects of the life of the passerines. Though these parasites may strongly affect the health and thus migration patterns of the birds also during autumn, previous studies on avian malaria focused mainly on the spring migration and the breeding periods of the birds. We investigated whether the prevalence of blood parasites varies in relation to biometrical traits, body condition and arrival time in the European Robin (Erithacus rubecula) during autumn migration. We found no sex or age related differences in avian malaria prevalence and no relationship between infection status and body size or actual condition of the birds was found either. However, the timing of autumn migration differed marginally between infected and non-infected juveniles, so that parasitized individuals arrived later at the Hungarian stopover site. This is either because avian malaria infections adversely affect the migration timing or migration speed of the birds, or because later arriving individuals come from more distant populations with possibly higher blood parasite prevalence. The possible delay that parasites cause in the arrival time of the birds during autumn migration could affect the whole migratory strategy and the breeding success of the birds in the next season.
Development and evaluation of molecular tools for detecting and differentiating intestinal amoebae in healthy individuals
Authors: Chihi Amal , Stensvold Christen R. , Ben-abda Imene , Ben-Romdhane Rania , Aoun Karim , Siala Emna , Bouratbine Aïda 
Published: January 2019

AbstractAmoebae are single-celled parasites frequently colonizing human gut. However, few molecular tools are available for accurate identification. Here, we evaluated a panel of polymerase chain reactions (PCRs) targeting Entamoeba histolytica, Entamoeba dispar, Entamoeba coli, Entamoeba hartmanni, Entamoeba polecki, Endolimax nana and Iodamoeba bütschlii. Thirty-six faecal samples (18 containing at least one amoeba species by microscopy and 18 microscopy negative for amoebae) were tested. Real-time PCRs were used for detection and differentiation of E. histolytica and E. dispar. Conventional PCR with Sanger sequencing were applied for detection and differentiation of E. coli, E. hartmanni, E. polecki, E. nana and I. bütschlii. All microscopy results were confirmed by DNA-based methods. However, more samples were positive for single and mixed amoebic species by DNA-based assays than by microscopy (22 vs 18 and 7 vs 1, respectively). DNA sequencing allowed identification of E. coli subtypes (ST1 and ST2), showed low intra-specific variation within E. hartmanni, identified two phylogenetically distinct groups within E. nana, and identified Iodamoeba at the ribosomal lineage level. Taking into account the high intra-genetic diversity within some of the species at the small subunit (SSU) rRNA gene level, amplification of SSU rRNA genes with subsequent sequencing represents a useful method for detecting, differentiating and subtyping intestinal amoebae.
Mother–infant cortisol attunement: Associations with mother–infant attachment disorganization
Authors: (Ludmer) Nofech-Mozes Jaclyn A. , Jamieson Brittany , Gonzalez Andrea , Atkinson Leslie 
Published: January 2019

AbstractThis study explores the conceptualization of mother–infant cortisol attunement both theoretically and empirically, and its association with mother–infant attachment disorganization. In a community sample (N= 256), disorganization and cortisol were assessed during the Strange Situation Procedure (SSP) at infant age 17 months. Salivary cortisol was collected at baseline, and 20 and 40 min after the SSP. We utilized three statistical approaches: correlated growth modeling (probing a simultaneous conceptualization of attunement), cross-lagged modeling (probing a lagged, reciprocal conceptualization of attunement), and a multilevel model difference score analysis (to examine the pattern of discrepancies in mother–infant cortisol values). Correlated growth modeling revealed that disorganized, relative to organized, dyads had significant magnitude of change over time, such that, among disorganized dyads, as mothers had greater declines in cortisol, infants had greater increases. The difference score analysis revealed that disorganized, relative to organized, dyads had a greater divergence between maternal and infant cortisol values, such that maternal values were lower than infant values. Disorganized attachment status was not significantly associated with attunement when conceptualized as reciprocal and lagged in the cross-lagged model. Findings suggest that mother–infant dyads in disorganized attachment relationships, who are by definition behaviorally misattuned, are also misattuned in their adrenocortical responses.
Minding the Baby®: Enhancing parental reflective functioning and infant attachment in an attachment-based, interdisciplinary home visiting program
Authors: Slade Arietta , Holland Margaret L. , Ordway Monica Roosa , Carlson Elizabeth A. , Jeon Sangchoon , Close Nancy , Mayes Linda C. , Sadler Lois S. 
Published: January 2019

AbstractIn this article, we describe the results of the second phase of a randomized controlled trial of Minding the Baby (MTB), an interdisciplinary reflective parenting intervention for infants and their families. Young first-time mothers living in underserved, poor, urban communities received intensive home visiting services from a nurse and social worker team for 27 months, from pregnancy to the child's second birthday. Results indicate that MTB mothers' levels of reflective functioning was more likely to increase over the course of the intervention than were those of control group mothers. Likewise, infants in the MTB group were significantly more likely to be securely attached, and significantly less likely to be disorganized, than infants in the control group. We discuss our findings in terms of their contribution to understanding the impacts and import of intensive intervention with vulnerable families during the earliest stages of parenthood in preventing the intergenerational transmission of disrupted relationships and insecure attachment.
The Response of Earth's Electron Radiation Belts to Geomagnetic Storms: Statistics From the Van Allen Probes Era Including Effects From Different Storm Drivers
Authors: Turner D. L. , Kilpua E. K. J. , Hietala H. , Claudepierre S. G. , O'Brien T. P. , Fennell J. F. , Blake J. B. , Jaynes A. N. , Kanekal S. , Baker D. N. , Spence H. E. , Ripoll J.‐F. , Reeves G. D. 
Published: January 2019

AbstractA statistical study was conducted of Earth's radiation belt electron response to geomagnetic storms using NASA's Van Allen Probes mission. Data for electrons with energies ranging from 30 keV to 6.3 MeV were included and examined as a function of L‐shell, energy, and epoch time during 110 storms with SYM‐H ≤−50 nT during September 2012 to September 2017 (inclusive). The radiation belt response revealed clear energy and L‐shell dependencies, with tens of keV electrons enhanced at all L‐shells (2.5 ≤ L ≤ 6) in all storms during the storm commencement and main phase and then quickly decaying away during the early recovery phase, low hundreds of keV electrons enhanced at lower L‐shells (~3 ≤ L ≤ ~4) in upward of 90% of all storms and then decaying gradually during the recovery phase, and relativistic electrons throughout the outer belt showing main phase dropouts with subsequent and generally unpredictable levels of replenishment during the recovery phase. Compared to prestorm levels, electrons with energies >1 MeV also revealed a marked increase in likelihood of a depletion at all L‐shells through the outer belt (3.5 ≤ L ≤ 6). Additional statistics were compiled revealing the storm time morphology of the radiation belts, confirming the aforementioned qualitative behavior. Considering storm drivers in the solar wind: storms driven by coronal mass ejection (CME) shocks/sheaths and CME ejecta only are most likely to result in a depletion of >1‐MeV electrons throughout the outer belt, while storms driven by full CMEs and stream interaction regions are most likely to produce an enhancement of MeV electrons at lower (L < ~5) and higher (L > ~4.5) L‐shells, respectively. CME sheaths intriguingly result in a distinct enhancement of ~1‐MeV electrons around L~5.5, and on average, CME sheaths and stream interaction regions result in double outer belt structures.
Developments in the MPI‐M Earth System Model version 1.2 (MPI‐ESM1.2) and Its Response to Increasing CO2
Authors: Mauritsen Thorsten , Bader Jürgen , Becker Tobias , Behrens Jörg , Bittner Matthias , Brokopf Renate , Brovkin Victor , Claussen Martin , Crueger Traute , Esch Monika , Fast Irina , Fiedler Stephanie , Fläschner Dagmar , Gayler Veronika , Giorgetta Marco , Goll Daniel S. , Haak Helmuth , Hagemann Stefan , Hedemann Christopher , Hohenegger Cathy , Ilyina Tatiana , Jahns Thomas , Jimenéz‐de‐la‐Cuesta Diego , Jungclaus Johann , Kleinen Thomas , Kloster Silvia , Kracher Daniela , Kinne Stefan , Kleberg Deike , Lasslop Gitta , Kornblueh Luis , Marotzke Jochem , Matei Daniela , Meraner Katharina , Mikolajewicz Uwe , Modali Kameswarrao , Möbis Benjamin , Müller Wolfgang A. , Nabel Julia E. M. S. , Nam Christine C. W. , Notz Dirk , Nyawira Sarah‐Sylvia , Paulsen Hanna , Peters Karsten , Pincus Robert , Pohlmann Holger , Pongratz Julia , Popp Max , Raddatz Thomas Jürgen , Rast Sebastian , Redler Rene , Reick Christian H. , Rohrschneider Tim , Schemann Vera , Schmidt Hauke , Schnur Reiner , Schulzweida Uwe , Six Katharina D. , Stein Lukas , Stemmler Irene , Stevens Bjorn , von Storch Jin‐Song , Tian Fangxing , Voigt Aiko , Vrese Philipp , Wieners Karl‐Hermann , Wilkenskjeld Stiig , Winkler Alexander , Roeckner Erich 
Published: January 2019

AbstractA new release of the Max Planck Institute for Meteorology Earth System Model version 1.2 (MPI‐ESM1.2) is presented. The development focused on correcting errors in and improving the physical processes representation, as well as improving the computational performance, versatility, and overall user friendliness. In addition to new radiation and aerosol parameterizations of the atmosphere, several relatively large, but partly compensating, coding errors in the model's cloud, convection, and turbulence parameterizations were corrected. The representation of land processes was refined by introducing a multilayer soil hydrology scheme, extending the land biogeochemistry to include the nitrogen cycle, replacing the soil and litter decomposition model and improving the representation of wildfires. The ocean biogeochemistry now represents cyanobacteria prognostically in order to capture the response of nitrogen fixation to changing climate conditions and further includes improved detritus settling and numerous other refinements. As something new, in addition to limiting drift and minimizing certain biases, the instrumental record warming was explicitly taken into account during the tuning process. To this end, a very high climate sensitivity of around 7 K caused by low‐level clouds in the tropics as found in an intermediate model version was addressed, as it was not deemed possible to match observed warming otherwise. As a result, the model has a climate sensitivity to a doubling of CO2 over preindustrial conditions of 2.77 K, maintaining the previously identified highly nonlinear global mean response to increasing CO2 forcing, which nonetheless can be represented by a simple two‐layer model.
Effect of large magnetotactic bacteria with polyphosphate inclusions on the phosphate profile of the suboxic zone in the Black Sea
Authors: Schulz-Vogt Heide N , Pollehne Falk , Jürgens Klaus , Arz Helge W , Beier Sara , Bahlo Rainer , Dellwig Olaf , Henkel Jan V , Herlemann Daniel P R , Krüger Siegfried , Leipe Thomas , Schott Thomas 
Published: January 2019

Abstract
The Black Sea is the world’s largest anoxic basin and a model system for studying processes across redox gradients. In between the oxic surface and the deeper sulfidic waters there is an unusually broad layer of 10–40 m, where neither oxygen nor sulfide are detectable. In this suboxic zone, dissolved phosphate profiles display a pronounced minimum at the upper and a maximum at the lower boundary, with a peak of particulate phosphorus in between, which was suggested to be caused by the sorption of phosphate on sinking particles of metal oxides. Here we show that bacterial polyphosphate inclusions within large magnetotactic bacteria related to the genus Magnetococcus contribute substantially to the observed phosphorus peak, as they contain 26–34% phosphorus compared to only 1–5% in metal-rich particles. Furthermore, we found increased gene expression for polyphosphate kinases by several groups of bacteria including Magnetococcaceae at the phosphate maximum, indicating active bacterial polyphosphate degradation. We propose that large magnetotactic bacteria shuttle up and down within the suboxic zone, scavenging phosphate at the upper and releasing it at the lower boundary. In contrast to a passive transport via metal oxides, this bacterial transport can quantitatively explain the observed phosphate profiles.
Dissecting Heterosis During the Ear Inflorescence Development Stage in Maize via a Metabolomics-based Analysis
Authors: Shi Xia , Zhang Xuehai , Shi Dakun , Zhang Xiangge , Li Weihua , Tang Jihua 
Published: January 2019

AbstractHeterosis can increase the yield of many crops and has been extensively applied in agriculture. In maize, female inflorescence architecture directly determines grain yield. Thus, exploring the relationship between early maize ear inflorescence development and heterosis regarding yield-related traits may be helpful for characterizing the molecular mechanisms underlying heterotic performance. In this study, we fine mapped the overdominant heterotic locus (hlEW2b), associated with ear width, in an approximately 1.98-Mb region based on analyses of chromosome segment substitution lines and the corresponding testcross population. Maize ear inflorescences at the floral meristem stage were collected from two inbred lines, one chromosome segment substitution line that carried hlEW2b (sub-CSSL16), the receptor parent lx9801, and the Zheng58 × sub-CSSL16 and Zheng58 × lx9801 hybrid lines. A total of 256 metabolites were identified, including 31 and 24 metabolites that were differentially accumulated between the two hybrid lines and between the two inbred lines, respectively. Most of these metabolites are involved in complex regulatory mechanisms important for maize ear development. For example, nucleotides are basic metabolites affecting cell composition and carbohydrate synthesis. Additionally, nicotinate and nicotinamide metabolism is important for photosynthesis, plant stress responses, and cell expansion. Moreover, flavonoid and phenolic metabolites regulate auxin transport and cell apoptosis. Meanwhile, phytohormone biosynthesis and distribution influence the cell cycle and cell proliferation. Our results revealed that changes in metabolite contents may affect the heterotic performance related to ear width and yield in maize hybrid lines. This study provides new clues in heterosis at the metabolomics level and implies that differentially accumulated metabolites made distinct contributions to the heterosis at an early stage of ear inflorescences development.
AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells
Authors: Coa Larissa Leggieri , Abreu Thiago Ferreira , Tashima Alexandre Keiji , Green Janaina , Pascon Renata Castiglioni , Vallim Marcelo Afonso , Machado-Jr Joel 
Published: January 2019

Abstract
The serine-threonine kinase AKT/PKB is a critical regulator of various essential cellular processes, and dysregulation of AKT has been implicated in many diseases, including cancer. Despite AKT action is known to function mainly in the cytoplasm, AKT has been reported to translocate to the nucleus. However, very little is known about the mechanism required for the nuclear import of AKT as well as its function in this cellular compartment. In the present study, we characterized the presence of endogenous nuclear AKT in human melanoma cells and addressed the possible role of AKT by exploring its potential association with key interaction nuclear partners. Confocal and Western blot analyses showed that both phosphorylated and non-phosphorylated forms of AKT are present in melanoma cells nuclei. Using mass spectrometry in combination with protein-crosslinking and co-immunoprecipitation, we identified a series of putative protein partners of nuclear AKT, including heterogeneous nuclear ribonucleoprotein (hnRNP), cytoskeleton proteins β-actin, γ-actin, β-actin-like 2 and vimentin. Confocal microscopy and biochemical analyses validated β-actin as a new nuclear AKT-interacting partner. Cofilin and active RNA Polymerase II, two proteins that have been described to interact and work in concert with nuclear actin in transcription regulation, were also found associated with nuclear AKT. Overall, the present study uncovered a yet unrecognized nuclear coupling of AKT and provides insights into the involvement of AKT in the interaction network of nuclear actin.
Cystatin C for predicting all-cause mortality and rehospitalization in patients with heart failure: a meta-analysis
Authors: Chen Shenghua , Tang Yangzhang , Zhou Xueyin 
Published: January 2019

Abstract
Circulating cystatin C (cys-C/CYC) has been identified as an independent predictor of all-cause mortality in patients with coronary artery disease and the general population. This meta-analysis aimed to systematically evaluate the association between elevated cys-C level and all-cause mortality and rehospitalization risk amongst patients with heart failure (HF). PubMed and Embase databases were searched until December 2017. All prospective observational studies that reported a multivariate-adjusted risk estimate of all-cause mortality and/or rehospitalization for the highest compared with lowest cys-C level in HF patients were included. Ten prospective studies involving 3155 HF patients were included. Meta-analysis indicated that the highest compared with lowest cys-C level was associated with an increased risk of all-cause mortality (hazard ratio (HR): 2.33; 95% confidence intervals (CI): 1.67–3.27; I2 = 75.0%, P&lt;0.001) and combination of mortality/rehospitalization (HR: 2.06; 95%CI: 1.58–2.69; I2 = 41.6%, P=0.181). Results of stratified analysis indicated that the all-cause mortality risk was consistently found in the follow-up duration, cys-C cut-off value or type of HF subgroup. Elevated cys-C level is possibly associated with an increased risk of all-cause mortality and rehospitalization in HF patients. This increased risk is probably independent of creatinine or estimated glomerular filtration rate (eGFR).