bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane
Authors: Lin Changhong , Sheng Dekun , Liu Xiangdong , Xu Shaobin , Ji Fance , Dong Li , Zhou Yan , Yang Yuming 
Published: October 2019

ABSTRACTA dual crosslinked self‐healing polyurethane was prepared with robust mechanical properties through the dynamic reversible pyridine‐Fe3+ coordination bonds and Diels–Alder (DA) covalent bonds dual crosslinking strategy. Moreover, the mechanical properties and self‐healing ability of polyurethane can be tuned readily by different ratio of the coordination bonds and DA bonds. Under external load, the coordination bonds serve as sacrificial bonds are broken to dissipate energy, the DA bonds can keep the shape of sample. With the coordination bonds participation, the damaged samples can be healed under moderate heating treatment or with the aid of FeCl3 solution. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2228–2234
Comparing in vivo and ex vivo fiberoptic diffuse reflectance spectroscopy in colorectal cancer
Authors: Baltussen Elisabeth J.M. , Brouwer De Koning Susan G. , Hendriks Benno H.W. , Jóźwiak Katarzyna , Sterenborg Henricus J.C.M. , Ruers Theo J.M. 
Published: October 2019

AbstractIn vivo data acquisition using fiberoptic diffuse reflectance spectroscopy (DRS) is more complicated and less controlled compared to ex vivo data acquisition. It would be of great benefit if classifiers for in vivo tissue discrimination based on DRS could be trained on data obtained ex vivo. In this study, in vivo and ex vivo DRS measurements are obtained during colorectal cancer surgery. A mixed model statistical analysis is used to examine the differences between the two datasets. Furthermore, classifiers are trained and tested using in vivo and ex vivo data. It is found that with a classifier trained on ex vivo data and tested on in vivo data, similar results are obtained compared to a classifier trained and tested on in vivo data. In conclusion, under the conditions used in this study, classifiers intended for in vivo tissue discrimination can be trained on ex vivo data.
Engaging Practitioners as Inquirers: Co-constructing Visions for Music Teacher Education in Nepal
Authors: Treacy Danielle Shannon 
Published: October 2019

AbstractThis chapter explores how co-constructing visions might engage teachers as inquirers in a ‘majority world’ context by reflecting on a series of 16 Appreciative Inquiry workshops involving over 50 musician-teachers in the Kathmandu Valley, Nepal in 2016. It extends the concept of teachers’ visions (Hammerness, Teach Educ Q 31(Fall):33–43, 2004) through socio-cultural anthropologist Arjun Appadurai’s notions of the imagination (Modernity at large: Cultural dimensions of globalization. University of Minnesota Press, Minneapolis, 1996) and the social and cultural capacity to aspire (Culture and public action. Stanford University Press, Stanford, 2004). The chapter reflects on the processes that took place when co-constructing visions, including the ways co-constructing visions may have been the fuel for action, and analyzes the implications of the resulting co-constructed visions. The findings highlight the importance of developing and supporting collaborative learning for the development of both preservice and inservice music teacher education.
Evaluating prior predictions of production and seismic data
Authors: Alfonzo Miguel , Oliver Dean S. 
Published: October 2019

Abstract
It is common in ensemble-based methods of history matching to evaluate the adequacy of the initial ensemble of models through visual comparison between actual observations and data predictions prior to data assimilation. If the model is appropriate, then the observed data should look plausible when compared to the distribution of realizations of simulated data. The principle of data coverage alone is, however, not an effective method for model criticism, as coverage can often be obtained by increasing the variability in a single model parameter. In this paper, we propose a methodology for determining the suitability of a model before data assimilation, particularly aimed for real cases with large numbers of model parameters, large amounts of data, and correlated observation errors. This model diagnostic is based on an approximation of the Mahalanobis distance between the observations and the ensemble of predictions in high-dimensional spaces. We applied our methodology to two different examples: a Gaussian example which shows that our shrinkage estimate of the covariance matrix is a better discriminator of outliers than the pseudo-inverse and a diagonal approximation of this matrix; and an example using data from the Norne field. In this second test, we used actual production, repeat formation tester, and inverted seismic data to evaluate the suitability of the initial reservoir simulation model and seismic model. Despite the good data coverage, our model diagnostic suggested that model improvement was necessary. After modifying the model, it was validated against the observations and is now ready for history matching to production and seismic data. This shows that the proposed methodology for the evaluation of the adequacy of the model is suitable for large realistic problems.
Acceptability of intravenous propofol sedation for adolescent dental care
Authors: Dixon C. , Aspinall A. , Rolfe S. , Stevens C. 
Published: October 2019

Abstract

Purpose
Propofol is an intravenous anaesthetic agent commonly utilised in general anaesthesia, however in sub-anaesthetic concentrations can be utilised to provide sedation through automated dosing of target-controlled infusion (TCI). TCI has been shown to provide accurate and stable predicted plasma and effect-site concentrations of propofol. A four-part mixed-method prospective study was undertaken to evaluate the safety and patient acceptability of intravenous propofol sedation in adolescent patients requiring dental care. There is a paucity in the literature on patient-reported outcomes and patient safety in the management of adolescent patients for dental treatment.

Methods
Demographics were recorded including age, gender, ASA Classification and Children’s Fear Survey Schedule—Dental Subscale (CFSS-DS) completed pre-operatively. Behaviour ratings of the Frankl and Houpt scales were recorded followed by post-operative questionnaire and telephone consultation. Consultation was completed following the procedure to determine patient satisfaction, memory of the procedure and any reported side effects of treatment. Qualitative thematic analysis was utilised.

Results
55 patients were recruited for the study, of which 49 (mean age 14.67 years) completed the sedation study and were treated safely with no post-operative complications. The mean lowest oxygen saturation was 98.12% SpO2 (SD 2.6). Thematic analysis demonstrated positive patient-reported outcomes to IV sedation.

Conclusion
Propofol TCI sedation is an effective treatment modality for the management of dentally anxious adolescents as a safe alternative to general anaesthesia, allowing the opportunity for increased provision of treatment per visit on those patients with a high dental need. Further randomised controlled trials comparing propofol TCI to other pharmacological managements are required.
Fooled by Rounding
Authors: Mason John , Zazkis Rina 
Published: October 2019

Abstract
For any convex quadrilateral, joining each vertex to the mid-point of the next-but-one edge in a clockwise direction produces an inner quadrilateral (as does doing so in a counter-clockwise direction). In many cases, a dynamic geometry measurement of the ratio of the area of the outer quadrilateral to the area of the inner one appears to be 5:1. It turns out, however, that this is due to rounding. We generalise the construction by replacing mid-points by more general ratios, finding the maximum and minimum values of the area ratio and determining the conditions on the original quadrilateral that achieve those two extremes.
Effects of plant extracts and essential oils on the behavior of Acrobasis advenella (Zinck.) caterpillars and females
Authors: Magierowicz Klaudia , Górska-Drabik Edyta , Golan Katarzyna 
Published: October 2019

AbstractAt present,Acrobasis advenella(Zinck.) (Lepidoptera, Pyralidae) is the most dangerous pest of black chokeberry (Aronia melanocarpa[Michx.] Elliot). Damaged flower buds may decrease yield, while pest feeding inside fruits causes deterioration in their quality. The aim of the study was to determine and compare the effect of water and acetone plants extracts and essential oils using free choice tests of feeding site of larvae and oviposition of females. The following species were examined:Achillea millefolium,Cymbopogon citratus,Nepeta cataria,Origanum vulgare,Satureja hortensis,Tagetes patula nana,Tanacetum vulgareandThymus vulgaris. The results showed that plant species had a significant influence on the choice of oviposition and feeding site ofA. advenella. Moreover, the type of formulation affected the number of laid eggs. Females did not lay eggs on infructescences treated with acetone extracts. Among the test preparations, the highest percentage larvae and adults ofA. advenellawas recorded for plants soaked inC. citratus, and therefore it can be a potential attractant for this pest species. The lowest number of eggs and larvae was observed forT. vulgare.
Uniformly perfect finitely generated simple left orderable groups
Authors: HYDE JAMES , LODHA YASH , NAVAS ANDRÉS , RIVAS CRISTÓBAL 
Published: October 2019

We show that the finitely generated simple left orderable groups $G_{\!\unicode[STIX]{x1D70C}}$ constructed by the first two authors in Hyde and Lodha [Finitely generated infinite simple groups of homeomorphisms of the real line. Invent. Math. (2019), doi:10.1007/s00222-019-00880-7] are uniformly perfect—each element in the group can be expressed as a product of three commutators of elements in the group. This implies that the group does not admit any homogeneous quasimorphism. Moreover, any non-trivial action of the group on the circle, which lifts to an action on the real line, admits a global fixed point. It follows that any faithful action on the real line without a global fixed point is globally contracting. This answers Question 4 of the third author [A. Navas. Group actions on 1-manifolds: a list of very concrete open questions. Proceedings of the International Congress of Mathematicians, Vol. 2. Eds. B. Sirakov, P. Ney de Souza and M. Viana. World Scientific, Singapore, 2018, pp, 2029–2056], which asks whether such a group exists. This question has also been answered simultaneously and independently, using completely different methods, by Matte Bon and Triestino [Groups of piecewise linear homeomorphisms of flows. Preprint, 2018, arXiv:1811.12256]. To prove our results, we provide a characterization of elements of the group $G_{\!\unicode[STIX]{x1D70C}}$ which is a useful new tool in the study of these examples.
Long Monotone Trails in Random Edge-Labellings of Random Graphs
Authors: Angel Omer , Ferber Asaf , Sudakov Benny , Tassion Vincent 
Published: October 2019

AbstractGiven a graph G and a bijection f : E(G) → {1, 2,…,e(G)}, we say that a trail/path in G is f-increasing if the labels of consecutive edges of this trail/path form an increasing sequence. More than 40 years ago Chvátal and Komlós raised the question of providing worst-case estimates of the length of the longest increasing trail/path over all edge orderings of Kn. The case of a trail was resolved by Graham and Kleitman, who proved that the answer is n-1, and the case of a path is still wide open. Recently Lavrov and Loh proposed studying the average-case version of this problem, in which the edge ordering is chosen uniformly at random. They conjectured (and Martinsson later proved) that such an ordering with high probability (w.h.p.) contains an increasing Hamilton path.In this paper we consider the random graph G = Gn,p with an edge ordering chosen uniformly at random. In this setting we determine w.h.p. the asymptotics of the number of edges in the longest increasing trail. In particular we prove an average-case version of the result of Graham and Kleitman, showing that the random edge ordering of Kn has w.h.p. an increasing trail of length (1-o(1))en, and that this is tight. We also obtain an asymptotically tight result for the length of the longest increasing path for random Erdős-Renyi graphs with p = o(1).
The paradox of state identification:de factostates, recognition, and the (re-)production of the international
Authors: Grzybowski Janis 
Published: October 2019

AbstractThe literature onde factostates challenges the conventional identification of states by legal recognition, proposing to identify states based on their effectiveness instead. Yet, as I argue in this paper, rather than turning the tables on recognition, thede factostate challenge ultimately reveals all state identification in International Relations and international law to be essentially indeterminate. This lacuna, I suggest, is not an accidental omission, but an expression of the foundational paradox of modern political order that is rooted in the intertwined ontology of the state system and the individual states constituting it, with each presupposing the other. As a result, the opposition between empirical facts, political decisions, and legal norms invoked in attempts to identify states cannot but remain irresolvable. This should not be regarded as a problem to be overcome, however, but as a source of social order. Although states cannot be substantively identified, any effort to do so in practice naturalizes the state as the very form through which we articulate and shape political claims, conflicts, and settlements. In performatively enacting states precisely at the contested margins, state identification thus both invokes and (re-)produces the statist international as the central imaginary of modern political order.
Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis
Authors: Dineva Stela , Uzunova Katya , Pavlova Velichka , Filipova Elena , Kalinov Krassimir , Vekov Toni 
Published: October 2019

Abstract
Hypertension is a complex syndrome of multiple hemodynamic, neuroendocrine, and metabolic abnormalities. The goals of treatment in hypertension are to optimally control high blood pressure and to reduce associated cardiovascular morbidity and mortality using the most suitable therapy available. Hydrochlorothiazide (HCTZ) and chlorthalidone (CTLD) are with proven hypertensive effects. The topic of our meta-analysis is to compare the efficacy of HCTZ and CTLD therapy in patient with hypertension. A search of electronic databases PubMed, MEDLINE, Scopus, PsyInfo, eLIBRARY.ru was performed. We chose the random-effects method for the analysis and depicted the results as forest plots. Sensitivity analyses were performed in order to evaluate the degree of significance of each study. Of the 1289 identified sources, only nine trials directly compared HCTZ and CTLD and were included in the meta-analysis. Changes in SBP lead to WMD (95% CI) equal to −3.26 mmHg showing a slight but statistically significant prevalence of CTLD. Results from analyzed studies referring to DBP lead to WMD (95% CI) equal to −2.41 mmHg, which is also statistically significant. During our analysis, we found that there were not enough studies presenting enough data on the effect of CTLD and HCTZ on levels of serum potassium and serum sodium. Our meta-analysis has demonstrated a slight superiority for CTLD regarding blood pressure control. At the same time, the two medications do not show significant differences in their safety profile.
Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants
Authors: Ju Chelsey , Fiori Laura M. , Belzeaux Raoul , Theroux Jean-Francois , Chen Gary Gang , Aouabed Zahia , Blier Pierre , Farzan Faranak , Frey Benicio N. , Giacobbe Peter , Lam Raymond W. , Leri Francesco , MacQueen Glenda M. , Milev Roumen , Müller Daniel J , Parikh Sagar V. , Rotzinger Susan , Soares Claudio N. , Uher Rudolf , Li Qingqin , Foster Jane A. , Kennedy Sidney H. , Turecki Gustavo 
Published: October 2019

AbstractMajor depressive disorder (MDD) is primarily treated with antidepressants, yet many patients fail to respond adequately, and identifying antidepressant response biomarkers is thus of clinical significance. Some hypothesis-driven investigations of epigenetic markers for treatment response have been previously made, but genome-wide approaches remain unexplored. Healthy participants (n = 112) and MDD patients (n = 211) between 18–60 years old were recruited for an 8-week trial of escitalopram treatment. Responders and non-responders were identified using differential Montgomery-Åsberg Depression Rating Scale scores before and after treatment. Genome-wide DNA methylation and gene expression analyses were assessed using the Infinium MethylationEPIC Beadchip and HumanHT-12 v4 Expression Beadchip, respectively, on pre-treatment peripheral blood DNA and RNA samples. Differentially methylated positions (DMPs) located in regions of differentially expressed genes between responders (n = 82) and non-responders (n = 95) were identified, and technically validated using a targeted sequencing approach. Three DMPs located in the genesCHN2(cg23687322,p = 0.00043 and cg06926818,p = 0.0014) andJAK2(cg08339825,p = 0.00021) were the most significantly associated with mRNA expression changes and subsequently validated. Replication was then conducted with non-responders (n = 76) and responders (n = 71) in an external cohort that underwent a similar antidepressant trial. OneCHN2site (cg06926818;p = 0.03) was successfully replicated. Our findings indicate that differential methylation at CpG sites upstream of theCHN2andJAK2TSS regions are possible peripheral predictors of antidepressant treatment response. Future studies can provide further insight on robustness of our candidate biomarkers, and greater characterization of functional components.
Pomalidomide and dexamethasone combination with additional cyclophosphamide in relapsed/refractory multiple myeloma (AMN001)—a trial by the Asian Myeloma Network
Authors: Soekojo Cinnie Yentia , Kim Kihyun , Huang Shang-Yi , Chim Chor-Sang , Takezako Naoki , Asaoku Hideki , Kimura Hideo , Kosugi Hiroshi , Sakamoto Junichi , Gopalakrishnan Sathish Kumar , Nagarajan Chandramouli , Wei Yuan , Moorakonda Rajesh , Lee Shu Ling , Lee Je Jung , Yoon Sung-Soo , Kim Jin Seok , Min Chang Ki , Lee Jae-Hoon , Durie Brian , Chng Wee Joo 
Published: October 2019

AbstractPomalidomide is a third generation immunomodulatory drug which in combination with dexamethasone, has been shown to be active in relapsed/refractory multiple myeloma. However, the data in Asian patients remain limited. We conducted a prospective phase two clinical trial in major cancer centers in Singapore, South Korea, Taiwan, Japan and Hong Kong to assess the efficacy and safety of pomalidomide and dexamethasone combination (PomDex) +/− cyclophosphamide in Asian patients with relapsed/refractory multiple myeloma who failed lenalidomide and bortezomib. Patients were treated with pomalidomide (4 mg daily for 21 days every 4 weeks) and dexamethasone (40 mg weekly). If there is less than a minimal response after three cycles of PomDex, cyclophosphamide 300 mg/m2 can be added (PomCyDex). A total of 136 patients were enrolled. The median PFS was 9 and 10.8 months for the PomDex and PomCyDex group, respectively. The median OS was 16.3 months. This regimen appears to be active across age groups and prior lines of treatment. This combination was overall well tolerated with grade 3 and 4 adverse events of mainly cytopenias. PomDex is highly active and well-tolerated in Asian patients. The addition of cyclophosphamide can improve the response and outcomes further in patients with suboptimal response to PomDex.
Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer
Authors: Page David B. , Bear Harry , Prabhakaran Sangeetha , Gatti-Mays Margaret E. , Thomas Alexandra , Cobain Erin , McArthur Heather , Balko Justin M. , Gameiro Sofia R. , Nanda Rita , Gulley James L. , Kalinsky Kevin , White Julia , Litton Jennifer , Chmura Steven J. , Polley Mei-Yin , Vincent Benjamin , Cescon David W. , Disis Mary L. , Sparano Joseph A. , Mittendorf Elizabeth A. , Adams Sylvia 
Published: October 2019

AbstractAntibodies blocking programmed death 1 (anti-PD-1) or its ligand (anti-PD-L1) are associated with modest response rates as monotherapy in metastatic breast cancer, but are generally well tolerated and capable of generating dramatic and durable benefit in a minority of patients. Anti-PD-1/L1 antibodies are also safe when administered in combination with a variety of systemic therapies (chemotherapy, targeted therapies), as well as with radiotherapy. We summarize preclinical, translational, and preliminary clinical data in support of combination approaches with anti-PD-1/L1 in metastatic breast cancer, focusing on potential mechanisms of synergy, and considerations for clinical practice and future investigation.
The ENERTALK dataset, 15 Hz electricity consumption data from 22 houses in Korea
Authors: Shin Changho , Lee Eunjung , Han Jeongyun , Yim Jaeryun , Rhee Wonjong , Lee Hyoseop 
Published: October 2019

AbstractAMI has been gradually replacing conventional meters because newer models can acquire more informative energy consumption data. The additional information has enabled significant advances in many fields, including energy disaggregation, energy consumption pattern analysis and prediction, demand response, and user segmentation. However, the quality of AMI data varies significantly across publicly available datasets, and low sampling rates and numbers of houses monitored seriously limit practical analyses. To address these challenges, we herein present the ENERTALK dataset, which contains both aggregate and per-appliance measurements sampled at 15 Hz from 22 houses. Among the publicly available datasets with both aggregate and per-appliance measurements, 15 Hz was the highest sampling rate. The number of houses (22) was the second-largest where the largest one had a sampling rate of 1 Hz. The ENERTALK dataset is also the first Korean open dataset on residential electricity consumption.
Generalizing the inverse FFT off the unit circle
Authors: Sukhoy Vladimir , Stoytchev Alexander 
Published: October 2019

AbstractThis paper describes the first algorithm for computing the inverse chirp z-transform (ICZT) inO(n log n) time. This matches the computational complexity of the chirp z-transform (CZT) algorithm that was discovered 50 years ago. Despite multiple previous attempts, an efficient ICZT algorithm remained elusive until now. Because the ICZT can be viewed as a generalization of the inverse fast Fourier transform (IFFT) off the unit circle in the complex plane, it has numerous practical applications in a wide variety of disciplines. This generalization enables exponentially growing or exponentially decaying frequency components, which cannot be done with the IFFT. The ICZT algorithm was derived using the properties of structured matrices and its numerical accuracy was evaluated using automated tests. A modification of the CZT algorithm, which improves its numerical stability for a subset of the parameter space, is also described and evaluated.