bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for prescription drug diversion among people living with HIV: a systematic scoping review
Authors: Chibi Buyisile , Torres Neusa F. , Sokhela Zinhle P. , Mashamba-Thompson Tivani P. 
Published: June 2019

ABSTRACT

Background:
In addition to numerous infections and frequent pain constantly affecting people living with HIV (PLWH), various risk factors might contribute to prescription drug diversion. The purpose of the study is to map existing evidence on risk factors contributing to prescription drug diversion among PLWH.

Methods:
Arksey and O’Malley's framework and the recommendation by Levac et al. (2010) guided this study. We searched for relevant literature from the following databases: PubMed; Google Scholar; EBSCOhost (Academic Search Complete, MEDLINE and Newspaper Source), Cochrane, WHO, HIV, ScienceDirect and Open Access Theses and Dissertations. Studies reporting evidence on risk factors contributing to prescription drug diversion and published in the period January 1996 to July 2017 were included. Thematic content analysis was performed to summarize the findings.

Results:
The search identified 734 studies. After full-text screening of the eligible studies, risk factors contributing to prescription drug diversion among PLWH were reported in 20 included studies. It was found that there is limited research on prescription drug diversion among PLWH in low–middle-income countries (LMICs). Risk factors contributing to prescription drug diversion were being a substance user or substance dependent; being male; young in age; being stigmatized; not disclosed HIV status; diagnosed with mental health problems; being HIV infected; poor health and well being; being White; being homeless or not owing a home; having low educational level; having history of diversion, misuse or abuse; in possession of addictive prescriptions; being unemployed and living in high neighbourhood disorder.

Conclusion:
Evidence shows that there is limited research on prescription drug diversion among PLWH in LMICs. The study findings show that the risk factors contributing to prescription drug diversion are related with risk factors for HIV transmission and infection.

PROSPERO registration number:
CRD42017074076.
Evolution of affiliation: patterns of convergence from genomes to behaviour
Authors: Fischer Eva K. , Nowicki Jessica P. , O'Connell Lauren A. 
Published: June 2019

Affiliative behaviours have evolved many times across animals. Research on the mechanisms underlying affiliative behaviour demonstrates remarkable convergence across species spanning wide evolutionary distances. Shared mechanisms have been identified with genomic approaches analysing genetic variants and gene expression differences as well as neuroendocrine and molecular approaches exploring the role of hormones and signalling molecules. We review the genomic and neural basis of pair bonding and parental care across diverse taxa to shed light on mechanistic patterns that underpin the convergent evolution of affiliative behaviour. We emphasize that mechanisms underlying convergence in complex phenotypes like affiliation should be evaluated on a continuum, where signatures of convergence may vary across levels of biological organization. In particular, additional comparative studies within and across major vertebrate lineages will be essential in resolving when and why shared neural substrates are repeatedly targeted in the independent evolution of affiliation, and how similar mechanisms are evolutionarily tuned to give rise to species-specific variations in behaviour.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions'.
Convergent evolution inArabidopsis halleriandArabidopsis arenosaon calamine metalliferous soils
Authors: Preite Veronica , Sailer Christian , Syllwasschy Lara , Bray Sian , Ahmadi Hassan , Krämer Ute , Yant Levi 
Published: June 2019

It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species,Arabidopsis halleriandArabidopsis arenosa, which co-occur at two calamine metalliferous (M) sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on M and non-metalliferous (NM) soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical single nucleotide polymorphisms in severalA. hallerigenes at two independently colonized M sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine M soils involves convergent evolution, which will probably be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Rate variation in the evolution of non-coding DNA associated with social evolution in bees
Authors: Rubin Benjamin E. R. , Jones Beryl M. , Hunt Brendan G. , Kocher Sarah D. 
Published: June 2019

The evolutionary origins of eusociality represent increases in complexity from individual to caste-based, group reproduction. These behavioural transitions have been hypothesized to go hand in hand with an increased ability to regulate when and where genes are expressed. Bees have convergently evolved eusociality up to five times, providing a framework to test this hypothesis. To examine potential links between putative gene regulatory elements and social evolution, we compare alignable, non-coding sequences in 11 diverse bee species, encompassing three independent origins of reproductive division of labour and two elaborations of eusocial complexity. We find that rates of evolution in a number of non-coding sequences correlate with key social transitions in bees. Interestingly, while we find little evidence for convergent rate changes associated with independent origins of social behaviour, a number of molecular pathways exhibit convergent rate changes in conjunction with subsequent elaborations of social organization. We also present evidence that many novel non-coding regions may have been recruited alongside the origin of sociality in corbiculate bees; these loci could represent gene regulatory elements associated with division of labour within this group. Thus, our findings are consistent with the hypothesis that gene regulatory innovations are associated with the evolution of eusociality and illustrate how a thorough examination of both coding and non-coding sequence can provide a more complete understanding of the molecular mechanisms underlying behavioural evolution.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Is there convergence of gut microbes in blood-feeding vertebrates?
Authors: Song Se Jin , Sanders Jon G. , Baldassarre Daniel T. , Chaves Jaime A. , Johnson Nicholas S. , Piaggio Antoinette J. , Stuckey Matthew J. , Nováková Eva , Metcalf Jessica L. , Chomel Bruno B. , Aguilar-Setién Alvaro , Knight Rob , McKenzie Valerie J. 
Published: June 2019

Animal microbiomes play an important role in dietary adaptation, yet the extent to which microbiome changes exhibit parallel evolution is unclear. Of particular interest is an adaptation to extreme diets, such as blood, which poses special challenges in its content of proteins and lack of essential nutrients. In this study, we assessed taxonomic signatures (by 16S rRNA amplicon profiling) and potential functional signatures (inferred by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt)) of haematophagy in birds and bats. Our goal was to test three alternative hypotheses: no convergence of microbiomes, convergence in taxonomy and convergence in function. We find a statistically significant effect of haematophagy in terms of microbial taxonomic convergence across the blood-feeding bats and birds, although this effect is small compared to the differences found between haematophagous and non-haematophagous species within the two host clades. We also find some evidence of convergence at the predicted functional level, although it is possible that the lack of metagenomic data and the poor representation of microbial lineages adapted to haematophagy in genome databases limit the power of this approach. The results provide a paradigm for exploring convergent microbiome evolution replicated with independent contrasts in different host lineages.
This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Robust Neural Networks are More Interpretable for Genomics
Authors: Koo Peter K. , Qian Sharon , Kaplun Gal , Volf Verena , Kalimeris Dimitris 
Published: June 2019

AbstractDeep neural networks (DNNs) have been applied to a variety of regulatory genomics tasks. For interpretability, attribution methods are employed to provide importance scores for each nucleotide in a given sequence. However, even with state-of-the-art DNNs, there is no guarantee that these methods can recover interpretable, biological representations. Here we perform systematic experiments on synthetic genomic data to raise awareness of this issue. We find that deeper networks have better generalization performance, but attribution methods recover less interpretable representations. Then, we show training methods promoting robustness – including regularization, injecting random noise into the data, and adversarial training – significantly improve interpretability of DNNs, especially for smaller datasets.
Functional connectivity strength within the auditory forebrain is altered by song learning and predicts song stereotypy in developing male zebra finches
Authors: Layden Elliot A. , Schertz Kathryn E. , Berman Marc G. , London Sarah E. 
Published: June 2019

AbstractMuch as humans acquire speech in early childhood, the zebra finch (Taeniopygia guttata) songbird learns to sing from an adult “tutor” during the first three months of life. Within a well-defined critical period (CP), juvenile zebra finches memorize a tutor song that will guide subsequent motor patterning. This sensory learning process is mediated by tutor experience-dependent neuroplasticity within the auditory forebrain. Here, we used longitudinal resting-state fMRI analyses to investigate whether tutor experience also modifies patterns of functional connectivity (FC) within the juvenile zebra finch brain. Eighteen male zebra finches (only males sing) were scanned before, during, and at the end of the CP, as well as at the young adult stage. Prior to the onset of the CP, birds were separated into rearing conditions: Normal (aviary-housed;N=5), Tutored (one adult male tutor and one adult female;N=7), and Isolate (two adult females, isolated from male song;N=6). Brain-wide voxel-wise analyses identified a single cluster overlapping the left caudomedial nidopallium (NCM) of the auditory forebrain that showed developmentally decreasing FC strength in Isolates but stable or increasing FC in Normal and Tutored birds. Additionally, FC between left NCM and left dorsal cerebellum showed a parallel developmental difference. Developmental changes in left NCM FC strength statistically mediated condition-related differences in song stereotypy. These results extend previous reports of tutor experience-dependent plasticity in NCM at epigenetic, genomic, molecular, and cellular levels to the whole-brain functional network level by demonstrating that tutor experience also influences the development of NCM FC. Moreover, these results link NCM FC to the emergence of song stereotypy.
A live-cell imaging system for visualizing the transport of Marburg virus nucleocapsid-like structures
Authors: Takamatsu Yuki , Noda Takeshi , Becker Stephan 
Published: June 2019

AbstractLive-cell imaging is a powerful tool for visualization of the spatio-temporal dynamics of living organisms. Although this technique is utilized to visualize nucleocapsid transport in Marburg virus (MARV)- or Ebola virus-infected cells, the experiments require biosafety level-4 (BSL-4) laboratories, which are restricted to trained and authorized individuals. To overcome this limitation, we developed a live-cell imaging system to visualize MARV nucleocapsid-like structures using fluorescence-conjugated viral proteins, which can be conducted outside BSL-4 laboratories. Our experiments revealed that nucleocapsid-like structures have similar transport characteristics to nucleocapsids observed in MARV-infected cells. This system provides a safe platform to evaluate antiviral drugs that inhibit MARV nucleocapsid transport.
High fat diet induces microbiota-dependent silencing of enteroendocrine cells
Authors: Ye Lihua , Mueller Olaf , Bagwell Jennifer , Bagnat Michel , Liddle Rodger A. , Rawls John F. 
Published: June 2019

ABSTRACTEnteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that sense and transduce nutrient information. Consumption of dietary fat contributes to metabolic disorders, but EEC adaptations to high fat feeding were unknown. Here, we established a new experimental system to directly investigate EEC activity in vivo using a zebrafish reporter of EEC calcium signaling. Our results reveal that high fat feeding alters EEC morphology and converts them into a nutrient insensitive state that is coupled to endoplasmic reticulum (ER) stress. We called this novel adaptation “EEC silencing”. Gnotobiotic studies revealed that germ-free zebrafish are resistant to high fat diet induced EEC silencing. High fat feeding altered gut microbiota composition including enrichment ofAcinetobacterspecies, and we identified anAcinetobacterstrain sufficient to induce EEC silencing. These results establish a new mechanism by which dietary fat and gut microbiota modulate EEC nutrient sensing and signaling.
Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognition
Authors: Dumas Guillaume , Malesys Simon , Bourgeron Thomas 
Published: June 2019

AbstractThe human brain differs from that of other primates, but the genetic basis of these differences remains unclear. We investigated the evolutionary pressures acting on almost all human protein-coding genes (N=11,667; 1:1 orthologs in primates) based on their divergence from those of early hominins, such as Neanderthals, and non-human primates. We confirm that genes encoding brain-related proteins are among the most strongly conserved protein-coding genes in the human genome. Combining our evolutionary pressure metrics for the protein-coding genome with recent datasets, we found that this conservation applied to genes functionally associated with the synapse and expressed in brain structures such as the prefrontal cortex and the cerebellum. Conversely, several genes presenting signatures commonly associated with positive selection appear as causing brain diseases or conditions, such as micro/macrocephaly, Joubert syndrome, dyslexia, and autism. Among those, a number of DNA damage response genes associated with microcephaly in humans such as BRCA1, NHEJ1, TOP3A, and RNF168 show strong signs of positive selection and might have played a role in human brain size expansion during primate evolution. We also showed that cerebellum granule neurons express a set of genes also presenting signatures of positive selection and that may have contributed to the emergence of fine motor skills and social cognition in humans. This resource is available online and can be used to estimate evolutionary constraints acting on a set of genes and to explore their relative contributions to human traits.
Energy efficient modeling and optimization for assembly sequence planning using moth flame optimization
Authors: Abdullah Arif , Ab Rashid Mohd Fadzil Faisae , Ponnambalam S.G. , Ghazalli Zakri 
Published: June 2019

Purpose
Environmental problems in manufacturing industries are a global issue owing to severe lack fossil resources. In assembly sequence planning (ASP), the research effort mainly aims to improve profit and human-related factors, but it still lacks in the consideration of the environmental issue. This paper aims to present an energy-efficient model for the ASP problem.

Design/methodology/approach
The proposed model considered energy utilization during the assembly process, particularly idle energy utilization. The problem was then optimized using moth flame optimization (MFO) and compared with well-established algorithms such as genetic algorithm (GA), particle swarm optimization (PSO) and ant colony optimization (ACO). A computational test was conducted using five assembly problems ranging from 12 to 40 components.

Findings
The results of the computational experiments indicated that the proposed model was capable of generating an energy-efficient assembly sequence. At the same time, the results also showed that MFO consistently performed better in terms of the best and mean fitness, with acceptable computational time.

Originality/value
This paper proposed a new energy-efficient ASP model that can be a guideline to design assembly station. Furthermore, this is the first attempt to implement MFO for the ASP problem.
Firm response, action visibility and consumers’ legitimacy judgment
Authors: Yuan Zhimei , Guo Yi , Wang Xingdong 
Published: June 2019

Purpose
The purpose of this paper is to examine the role of action visibility in moderating the relationship between firm response and individual legitimacy judgment. Since a firm may decouple its public commitment from its actual practice to cope with conflicting stakeholder interests, visibility is important for consumers to make judgment because it is difficult for them to observe a firm’s actual fulfillment of its public commitment to quality assurance after a product-harm crisis.

Design/methodology/approach
Scenario-based mixed design experiments were employed and 718 valid responses were collected.

Findings
The results indicated that, while acknowledging responsibility produced more favorable legitimacy judgment than denial, decoupling produced no better judgment than denial. However, higher visibility significantly amplified the effect size. Specifically, under the condition of high visibility, not only did acknowledging responsibility produce much more favorable judgment than denial, but so did decoupling.

Research limitations/implications
This study provided empirical evidence that action visibility moderated the relationship between firm response and individual legitimacy judgment, thus complementing the literature on crisis management.

Practical implications
This study provided executives or managers with optimal, suboptimal and least optimal response strategies under different levels of action visibility.

Originality/value
Much of the extant research on response strategy for organizations to deal with product-harm crisis ignored the moderating role of action visibility. Past research on legitimacy judgment focused on organization. This paper combined firm response, action visibility and individual-level legitimacy judgment.
The moderating effect of leader member exchange on the relationship between workplace ostracism and psychological distress
Authors: Choi Youngkeun 
Published: June 2019

PurposeBased on the conservation of resources theory, the purpose of this paper is to develop and test the relationship between workplace ostracism and psychological distress of male employees. And depending on the leader member exchange (LMX) theory, it assumes that the relationship between workplace ostracism and psychological distress of male employees is moderated by the LMX.Design/methodology/approachFor this, this study used a survey method and multiple regression analyses with multi-source data from 226 male Korean employees and their supervisors.FindingsThe results suggest the following. First, workplace ostracism was positively associated with job tension, emotional exhaustion and depressed moods at work for male employees. Second, there was a stronger positive relationship between workplace ostracism and job tension, or emotional exhaustion for male employees with low, as opposed to those with high, levels of LMX.Originality/valueThis study is the first one to examine the moderating effect of LMX on the relationship between workplace ostracism and psychological distress of male employees.
Destination food image, satisfaction and outcomes in a border context: tourists vs excursionists
Authors: Toudert Djamel , Bringas-Rábago Nora L. 
Published: June 2019

Purpose
The purpose of this paper is to examine the impact of cognitive destination food image in food expectation, satisfaction and visit outcomes within a local context of the USA–Mexico border. The differences between tourists and excursionists were also assessed for their possible implications in strengthening an active market strategy in the framework of the same objective.

Design/methodology/approach
Four hypotheses were examined through Squares SEM techniques. The model validation was carried out assessing the measurement and structural model. Additionally a multi-group analysis was performed to test the tourists and excursionists moderation effect. The study used 518 questionnaires completed by US visitors in three important gastronomic regions of the coast of Baja California, Mexico.

Findings
The results suggest that tourists and excursionists obey different dimensions when structuring cognitive destination food image which showed a significant impact on visitor satisfaction and future intentions.

Originality/value
The moderation function of tourists and excursionists in the causal relationships of the research model was analyzed as one of the first explorations in food tourism marketing. In conjunction with other findings, this paper offers specific theoretical and practical implications on how to stimulate gastronomic consumption in these two segments of visitors.