bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mexican Early Warning System for Space Weather
Authors: De la Luz V. , González-Esparza J. A. , Sergeeva M. , Corona-Romero P. , Mejía-Ambriz J. , González L. X. 
Published: July 2018

AbstractEarly Warning of Space Weather phenomena is one of the most important products produced by Mexican Space Weather Service (SCiESMEX). The aim is to deliver a verified warning to Mexican National Center for Disaster Prevention (CENAPRED) as well as to general public in near-real time automatically. First, the international pubic warning (or alert) is produced by Space Weather Prediction Center of National Oceanic and Atmospheric Administration, U.S.A. Further, the alert is received by SCiESMEX system, decodified, translated in Spanish and put in the context of local current conditions. The alerts are transformed and validated in agreement to Mexican policies of civil protection and CENAPRED protocols. The automatic system segments the information and delivers the corresponding web- page-alerts, emails, twits, facebook messages and SMS. The latency of the alert is 5 minutes. The code is running since January of 2015 without major interruptions.
Monitor and Prediction of Near-Earth Radiation Environment in the Frame of Space Monitoring Data Center at Moscow State University
Authors: Myagkova Irina N. , Kalegaev Vladimir V. , Panasyuk Mikhail I. , Shugai Yuliya S. , Dolenko Sergey A. , Bobrovnikov Sergey Yu. , Barinova Vera O. , Nguyen Minh Duc , Shiroky Vladimir R. , Eremeev Valery E. , Bogomolov Andrey V. , Barinov Oleg G. , Vlasova Natalia A. , Kusnetsov Nikolay V. 
Published: July 2018

AbstractRadiation environment of near-Earth space is one of the most important factors of space weather. Space Monitoring Data Center of Moscow State University provides operational monitor and forecast of radiation conditions both at Geostationary Orbits (GEO) and at Low Earths Orbits (LEO) of the near-Earth space using data of recent space missions (Vernov, CORONAS series) and current (Lomonosov, Meteor-M, Electro-L) ones. Internet portal of Space Monitoring Data Center of Skobeltsyn Institute of Nuclear Physics of Lomonosov Moscow State University (SINP MSU - [swx.sinp.msu.ru]) provides possibilities to monitor and analyze the space radiation conditions in the real time mode together with the geomagnetic and solar activity including hard X-ray and gamma-emission of solar flares.
CCMC Modeling of Magnetic Reconnection in Electron Diffusion Region Events
Authors: Reiff Patricia H. , Webster James M. , Daou Antoun G. , Marshall Andrew , Sazykin Stanislav Y. , Rastaetter Lutz , Welling Daniel T. , DeZeeuw Darren , Kuznetsova Maria M. , Glocer Alex , Russell Christopher T. 
Published: July 2018

AbstractWe use numerical simulations from the Community Coordinated Modeling Center to provide, for the first time, a coherent temporal description of the magnetic reconnection process of two dayside Electron Diffusion Regions (EDRs) identified in Magnetospheric Multiscale Mission data. The model places the MMS spacecraft near the separator line in these most intense and long-lived events. A listing of 31 dayside EDRs identified by the authors is provided to encourage collaboration in analysis of these unique encounters.
Simulating the Dynamics of Coronal Plasma Condensations
Authors: Kohutova Petra , Verwichte Erwin 
Published: July 2018

AbstractWe present numerical MHD simulations of the dynamics of cool plasma condensations in a coronal loop. We address 2 mechanisms for how coronal rain leads to the excitation of coronal loop oscillations. We find that the combined effect of pressure gradients in the coronal loop plasma and magnetic tension force resulting from changes in magnetic field geometry explains observed sub-ballistic motion of coronal rain and longitudinal oscillations of the individual condensations. We also find that the condensations can excite sustained, small amplitude, vertically polarised transverse loop oscillations.
How does the Sun Influence the Magnetospheres of Jupiter and Saturn?
Authors: Jackman Caitríona M. , Arridge Christopher S. 
Published: July 2018

AbstractSpacecraft have visited Jupiter and Saturn at all phases of the solar cycle and thus we have a wealth of data with which to explore both upstream parameters and magnetospheric response. In this paper we review upstream parameters including interplanetary magnetic field strength and direction, solar wind dynamic pressure, plasma beta and Mach number. We consider the impact of changing solar wind on dayside coupling via reconnection. We also comment on how solar UV flux variability over a solar cycle influences the plasma and neutral tori in the inner magnetospheres of Jupiter and Saturn, and thus estimate the solar cycle effects on internally driven magnetospheric dynamics. Finally we place our results in the context of the now complete set of data from the Cassini mission at Saturn and the current data streaming in from Juno at Jupiter, outlining future avenues for research.
The Ionosphere Prediction Service
Authors: Albanese Carlo , Rodriguez Filippo , Ronchini Roberto , Di Rollo Stefano , Berrilli Francesco , Cristaldi Alice , Del Moro Dario , Forte Roberta , De Franceschi Giorgiana , Cesaroni Claudio , Spogli Luca , Romano Vincenzo , Aquino Marcio , Veettil Sreeja Vadakke , Kalden Osman , Hutchinson Michael , Guyader Eric 
Published: July 2018

AbstractThe aim of the Ionosphere Prediction Service (IPS) project is to design and develop a prototype platform to translate the prediction and forecast of the ionosphere effects into a service customized for specific GNSS user communities. The project team is composed by Telespazio (coordinator), Nottingham Scientific Ltd, Telespazio Vega Deutschland, the University of Nottingham, the University of Rome “Tor Vergata” and the Italian Istituto Nazionale di Geofisica e Vulcanologia (INGV). The IPS development is conceived of two concurrent activities: prototype service design and development & research activity that will run along the whole project. Service design and development is conceived into four phases: user requirements collection, architecture specification, implementation and validation of the prototype. A sub-activity analyses also the integration feasibility in the Galileo Service center, located in Madrid. The research activity is the scientific backbone of IPS that will provide the models and algorithms for the forecasting products.
Re-Acceleration of Energetic Particles in Large-Scale Heliospheric Magnetic Cavities
Authors: Khabarova Olga V. , Malandraki Olga E. , Zank Gary P. , Li Gang , le Roux Jakobus A. , Webb Gary M. 
Published: July 2018

AbstractCase studies show that some energetic particle flux enhancements up to MeV/nuc. observed at 1 AU cannot be treated as a consequence of particle acceleration at shocks or during flares. Atypical energetic particle events (AEPEs) are often detected during crossings of magnetic cavities formed by strong current sheets of various origins in the solar wind. Such cavities confine small-scale magnetic islands (SMIs) produced by magnetic reconnection. SMIs, in turn, trap and re-accelerate energetic particles according to predictions based on the theory of Zanket al.describing stochastic particle energization in the supersonic solar wind via numerous dynamically interacting SMIs. AEPEs possess energies that overlap SEP events and can be an important component in understanding space weather.
The Space Weather through a Multidisciplinary Scientific Approach
Authors: Benkhaldoun Zouhair , Khalifa Malki , Bounhir Aziza , Vilmer Nicole , El bouyahyaoui Khaoula , Kaab Mohamed , Lagheryeb Amine , Daassou Ahmed 
Published: July 2018

AbstractSpace weather encompasses understanding how the near-space environment responds to forces from lower-atmosphere weather systems as well as conditions on the Sun. Although the specific effects of space weather (including power grid failures, communication outages, and navigation errors when using space-based navigation systems such as GPS) are local in nature, understanding and predicting their occurrence requires a global view of the environment. Here we initiated a first attempt to link one solar event which occurred on 2014 February 25, and affected the Earth’s upper atmosphere.
TRIANGULATING NON-ARCHIMEDEAN PROBABILITY
Authors: BRICKHILL HAZEL , HORSTEN LEON 
Published: July 2018

AbstractWe relate Popper functions to regular and perfectly additive such non-Archimedean probability functions by means of a representation theorem: every such non-Archimedean probability function is infinitesimally close to some Popper function, and vice versa. We also show that regular and perfectly additive non-Archimedean probability functions can be given a lexicographic representation. Thus Popper functions, a specific kind of non-Archimedean probability functions, and lexicographic probability functions triangulate to the same place: they are in a good sense interchangeable.
Impression-Motivated News Consumption
Authors: Winter Stephan 
Published: July 2018

Abstract. Social networking sites (SNS) such as Facebook are increasingly used as sources of news. The present research aimed to investigate whether this new media context affects the way in which readers process news articles and form their opinions on current debates. In an application of the heuristic-systematic model of persuasion, it was assumed that the high salience of self-presentation and interpersonal contacts in social media triggers an impression-motivated mode of reasoning in which readers base their attitudes more strongly on the majority opinion and social pressures. In a pre-registered laboratory experiment ( N = 210) in which participants read a news article, the media context (SNS vs. SNS with anticipation of future interaction vs. online news site) and the valence of the displayed user comments (positive vs. negative) were varied as between-subject factors. It was hypothesized that user comments are more influential when being logged in to Facebook than on classic online news sites, particularly when expecting future opinion expression about the topic and among people with a strong self-monitoring tendency. Results showed significant effects of comment valence on readers’ attitudes and valence of thoughts, however, this pattern also occurred in the setting of online news sites and was not moderated by self-monitoring. Findings are discussed with regard to the theoretical predictions of the heuristic-systematic model on following the majority opinion and practical implications for an informed citizenry.
Quantitative stable isotope probing with H2 18O reveals that most bacterial taxa in soil synthesize new ribosomal RNA
Authors: Papp Katerina , Mau Rebecca L , Hayer Michaela , Koch Benjamin J , Hungate Bruce A , Schwartz Egbert 
Published: July 2018

Abstract
Most soil bacterial taxa are thought to be dormant, or inactive, yet the extent to which they synthetize new rRNA is poorly understood. We analyzed 18O composition of RNA extracted from soil incubated with H2 18O and used quantitative stable isotope probing to characterize rRNA synthesis among microbial taxa. RNA was not fully labeled with 18O, peaking at a mean of 23.6 ± 6.8 atom percent excess (APE) 18O after eight days of incubation, suggesting some ribonucleotides in soil were more than eight days old. Microbial taxa varied in the degree they incorporated 18O into their rRNA over time and there was no correlation between the APE 18O of bacterial rRNA and their rRNA to DNA ratios, suggesting that the ratios were not appropriate to measure ribonucleotide synthesis. Our study indicates that, on average, 94% of soil taxa produced new rRNA and therefore were metabolically active.
LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci
Authors: Wang Shaowei , Ke Hao , Zhang Honglei , Ma Yujie , Ao Lei , Zou Li , Yang Qin , Zhu Hao , Nie Jianyun , Wu Chunlian , Jiao Baowei 
Published: July 2018

AbstractTriple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low survival. Long non-coding RNAs (lncRNAs) play critical roles in tumor progression. Here, we identified lncRNA MIR100HG as a pro-oncogene for TNBC progression. Knockdown of MIR100HG decreased cell proliferation and induced cell arrest in the G1 phase, whereas overexpression of MIR100HG significantly increased cell proliferation. Furthermore, MIR100HG regulated the p27 gene to control the cell cycle, and subsequently impacted the progression of TNBC. In analyzing its underlying mechanism, bioinformatics prediction and experimental data demonstrated that MIR100HG participated in the formation of RNA–DNA triplex structures. MIR100HG in The Cancer Genome Atlas (TCGA) and breast cancer cell lines showed higher expression in TNBC than in other tumor types with poor prognosis. In conclusion, our data indicated a novel working pattern of lncRNA in TNBC progression, which may be a potential therapeutic target in such cancers.
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Authors: Wyss Annah B. , Sofer Tamar , Lee Mi Kyeong , Terzikhan Natalie , Nguyen Jennifer N. , Lahousse Lies , Latourelle Jeanne C. , Smith Albert Vernon , Bartz Traci M. , Feitosa Mary F. , Gao Wei , Ahluwalia Tarunveer S. , Tang Wenbo , Oldmeadow Christopher , Duan Qing , de Jong Kim , Wojczynski Mary K. , Wang Xin-Qun , Noordam Raymond , Hartwig Fernando Pires , Jackson Victoria E. , Wang Tianyuan , Obeidat Ma’en , Hobbs Brian D. , Huan Tianxiao , Gui Hongsheng , Parker Margaret M. , Hu Donglei , Mogil Lauren S. , Kichaev Gleb , Jin Jianping , Graff Mariaelisa , Harris Tamara B. , Kalhan Ravi , Heckbert Susan R. , Paternoster Lavinia , Burkart Kristin M. , Liu Yongmei , Holliday Elizabeth G. , Wilson James G. , Vonk Judith M. , Sanders Jason L. , Barr R. Graham , de Mutsert Renée , Menezes Ana Maria Baptista , Adams Hieab H. H. , van den Berge Maarten , Joehanes Roby , Levin Albert M. , Liberto Jennifer , Launer Lenore J. , Morrison Alanna C. , Sitlani Colleen M. , Celedón Juan C. , Kritchevsky Stephen B. , Scott Rodney J. , Christensen Kaare , Rotter Jerome I. , Bonten Tobias N. , Wehrmeister Fernando César , Bossé Yohan , Xiao Shujie , Oh Sam , Franceschini Nora , Brody Jennifer A. , Kaplan Robert C. , Lohman Kurt , McEvoy Mark , Province Michael A. , Rosendaal Frits R. , Taylor Kent D. , Nickle David C. , Williams L. Keoki , Burchard Esteban G. , Wheeler Heather E. , Sin Don D. , Gudnason Vilmundur , North Kari E. , Fornage Myriam , Psaty Bruce M. , Myers Richard H. , O’Connor George , Hansen Torben , Laurie Cathy C. , Cassano Patricia A. , Sung Joohon , Kim Woo Jin , Attia John R. , Lange Leslie , Boezen H. Marike , Thyagarajan Bharat , Rich Stephen S. , Mook-Kanamori Dennis O. , Horta Bernardo Lessa , Uitterlinden André G. , Im Hae Kyung , Cho Michael H. , Brusselle Guy G. , Gharib Sina A. , Dupuis Josée , Manichaikul Ani , London Stephanie J. 
Published: July 2018

AbstractNearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.
Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
Authors: Guan Juan , Shen Qing , Zhang Zui , Jiang Zhuxuan , Yang Yang , Lou Meiqing , Qian Jun , Lu Weiyue , Zhan Changyou 
Published: July 2018

AbstractTargeting ligands are anticipated to facilitate the precise delivery of therapeutic agents to diseased tissues; however, they may also severely affect the interaction of nanocarriers with plasma proteins. Here, we study the immunocompatibility of brain-targeted liposomes, which inversely correlates with absorbed natural IgM. Modification of long, stable positively charged peptide ligands on liposomes is inclined to absorb natural IgM, leading to rapid clearance and enhanced immunogenicity. Small peptidomimetic D8 developed by computer-aided peptide design exhibits improved immunocompatibility by attenuating natural IgM absorption. The present study highlights the effects of peptide ligands on the formed protein corona and in vivo fate of liposomes. Stable positively charged peptide ligands play double-edged roles in targeted delivery, preserving in vivo bioactivities for binding receptors and long-term unfavorable interactions with the innate immune system. The development of D8 provides insights into how to rationally design immunocompatible drug delivery systems by modulating the protein corona composition.
Sanitation of blackwater via sequential wetland and electrochemical treatment
Authors: Talekar Guruprasad V. , Sharma Priya , Yadav Anant , Clauwaert Peter , Rabaey Korneel , Mutnuri Srikanth 
Published: July 2018

AbstractThe discharge of untreated septage is a major health hazard in countries that lack sewer systems and centralized sewage treatment. Small-scale, point-source treatment units are needed for water treatment and disinfection due to the distributed nature of this discharge, i.e., from single households or community toilets. In this study, a high-rate-wetland coupled with an electrochemical system was developed and demonstrated to treat septage at full scale. The full-scale wetland on average removed 79 ± 2% chemical oxygen demand (COD), 30 ± 5% total Kjeldahl nitrogen (TKN), 58 ± 4% total ammoniacal nitrogen (TAN), and 78 ± 4% ortho-phosphate. Pathogens such as coliforms were not fully removed after passage through the wetland. Therefore, the wetland effluent was subsequently treated with an electrochemical cell with a cation exchange membrane where the effluent first passed through the anodic chamber. This lead to in situ chlorine or other oxidant production under acidifying conditions. Upon a residence time of at least 6 h of this anodic effluent in a buffer tank, the fluid was sent through the cathodic chamber where pH neutralization occurred. Overall, the combined system removed 89 ± 1% COD, 36 ± 5% TKN, 70 ± 2% TAN, and 87 ± 2% ortho-phosphate. An average 5-log unit reduction in coliform was observed. The energy input for the integrated system was on average 16 ± 3 kWh/m3, and 11 kWh/m3under optimal conditions. Further research is required to optimize the system in terms of stability and energy consumption.
Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet
Authors: Bedja Djahida , Yan Wenwen , Lad Viren , Iocco Domenica , Sivakumar Nickash , Bandaru Veera Venkata Ratnam , Chatterjee Subroto 
Published: July 2018

AbstractSphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE−/−) decreases the level of ceramides and glucosylceramide. At the expense of increased levels of lactosylceramide due to an increase in the expression of lactosylceramide synthase (GalT-V). This is accompanied with neutrophil infiltration into dermis, and enrichment of tumor necrosis factor-stimulated gene-6 (TSG-6) protein. This causes skin inflammation, hair discoloration and loss, in ApoE−/− mice. Conversely, inhibition of glycosphingolipid synthesis, by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), unbound or encapsulated in a biodegradable polymer (BPD) reversed these phenotypes. Thus, inhibition of glycosphingolipid synthesis represents a unique therapeutic approach relevant to human skin and hair Biology.
Efficiency of generic and proprietary inhibitors in mitigating Corrosion of Carbon Steel in Chloride-Sulfate Environments
Authors: Al-Sodani Khaled A. Alawi , Maslehuddin Mohammed , Al-Amoudi Omar S. Baghabra , Saleh Tawfik A. , Shameem Mohammed 
Published: July 2018

AbstractThe efficiency of generic and proprietary corrosion inhibitors (based on nitrite, amine carboxylate or amino alcohol) in corrosion mitigation of carbon steel, which is exposed to concrete solutions with different amounts of chloride as well as sulfate, was studied. The corrosion protection provided by the selected corrosion inhibitors was investigated by performing a potentiodynamic polarization study. In addition, the surface morphological properties of carbon steel samples exposed to the electrolyte mixed with or without inhibitors was also evaluated by scanning electron microscopy. The potentiodynamic polarization measurements showed that the evaluated inhibitors decreased the corrosion current density by 1.6 to 6.7 times depending on the type of inhibitor and the level of sulfate concentration in the electrolyte. The performance of inhibitors based on nitrite was better than that of inhibitors based on amine carboxylate or amino alcohol. The possible mechanisms of the inhibition in the chloride plus sulfate environments are also elucidated.
Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome
Authors: Fung Jenny N. , Mortlock Sally , Girling Jane E. , Holdsworth-Carson Sarah J. , Teh Wan Tinn , Zhu Zhihong , Lukowski Samuel W. , McKinnon Brett D. , McRae Allan , Yang Jian , Healey Martin , Powell Joseph E. , Rogers Peter A. W. , Montgomery Grant W. 
Published: July 2018

AbstractGene expression varies markedly across the menstrual cycle and expression levels for many genes are under genetic control. We analyzed gene expression and mapped expression quantitative trait loci (eQTLs) in endometrial tissue samples from 229 women and then analyzed the overlap of endometrial eQTL signals with genomic regions associated with endometriosis and other reproductive traits. We observed a total of 45,923 cis-eQTLs for 417 unique genes and 2,968 trans-eQTLs affecting 82 unique genes. Two eQTLs were located in known risk regions for endometriosis including LINC00339 on chromosome 1 and VEZT on chromosome 12 and there was evidence for eQTLs that may be target genes in genomic regions associated with other reproductive diseases. Dynamic changes in expression of individual genes across cycle include alterations in both mean expression and transcriptional silencing. Significant effects of cycle stage on mean expression levels were observed for (2,427/15,262) probes with detectable expression in at least 90% of samples and for (2,877/9,626) probes expressed in some, but not all samples. Pathway analysis supports similar biological control of both altered expression levels and transcriptional silencing. Taken together, these data identify strong genetic effects on genes with diverse functions in human endometrium and provide a platform for better understanding genetic effects on endometrial-related pathologies.