bluuebunny/crossref_metadata_2025_split huggingface dataset:
RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins
Authors: Zhang Jing , Liu Jason , Lee Donghoon , Feng Jo-Jo , Lochovsky Lucas , Lou Shaoke , Rutenberg-Schoenberg Michael , Gerstein Mark 
Published: November 2018

AbstractRNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant-prioritization methods only focus on transcriptional regulation. Here, we integrate the portfolio of ENCODE-RBP experiments to develop RADAR, a variant-scoring framework. RADAR uses conservation, RNA structure, network centrality, and motifs to provide an overall impact score. Then it further incorporates tissue-specific inputs to highlight disease-specific variants. Our results demonstrate RADAR can successfully pinpoint variants, both somatic and germline, associated with RBP-function dysregulation, that cannot be found by most current prioritization methods, for example variants affecting splicing.
The Influence of Health Insurance on the Utilization of Maternal Health Care Services in Kumba Health District: A Community-based Assessment
Authors: Mbuli Mbunwe Doreen , Awolu Mbunka Muhamed , Asangbeng Tanue Elvis , Mbuli Innocent Ali , Pangmekeh Pepanze Jill , Shey Nsagha Dickson 
Published: November 2018

ABSTRACTBackgroundThe cash payments required to access services at health facilities called user fees are perceived to be a key barrier to improving maternal health care. This study was carried out to determine the influence of health insurance enrollment on the utilization of maternal health care services in Kumba Health District (KHD).MethodsThis was an analytic community-based cross-sectional study carried out in KHD, including women of child-bearing age who have had their latest delivery within 5years prior to the study. Six of the twelve health areas in the KHD were purposively selected due to the presence of health insurance companies. Probability proportionate to size sampling was used to determine the number of eligible women to be selected from each of the health areas. Data were entered into Excel 2013 and analyzed using SPSS version 20. Chi-square tests and Logistic regression were employed to identify associations between variables. Statistical significance was set at P<0.05.ResultsA total of 392 eligible women of child-bearing age (15-49years) were recruited into the study. A very high proportion, 94.4% of the women attended at least one ANC visit during their last pregnancy prior to the study. However, only 118(31.9%) started ANC in the critical first trimester. The prevalence of skilled facility delivery was 90.3% (95% CI: 87.2 – 93.1%). The proportion of women using a family planning method was low, 45.4% (95%CI: 49.5 – 59.2%). In multivariate analyses, insurance enrollment was significantly associated with family planning utilization (P-value: 0.000, AOR: 3.96, 95%CI: 2.14-7.35).ConclusionLess than a quarter of women of reproductive age are enrolled in health insurance in the KHD. Health insurance has been found to influence the utilization of family planning services in Kumba Health District, but not antenatal care and skilled facility delivery, though insured women are more likely to utilize these services than the uninsured. Universal health care coverage is, therefore, necessary to ensure financial accessibility to maternal health care services by all women.
The importance of large-diameter trees in the wet tropical rainforests of Australia
Authors: Bradford Matt , Murphy Helen T 
Published: November 2018

AbstractLarge trees are keystone structures in many terrestrial ecosystems. They contribute disproportionately to reproduction, recruitment and succession, and influence the structure, dynamics, and diversity of forests. Recently, researchers have become concerned about evidence showing rapid declines in large, old trees in a range of ecosystems across the globe. We used ≥10cm diameter at breast height (DBH) stem inventory data from 20, 0.5 ha forest plots spanning the wet tropical rainforest of Queensland, Australia to examine the contribution of large-diameter trees to above ground biomass (AGB), richness, dominance, mortality and recruitment. We show consistencies with tropical rainforest globally in that large-diameter trees (≥70 cm DBH) contribute much of the biomass (33%) from few trees (2.4% of stems ≥10cm DBH) with the density of the largest trees explaining much of the variation (62%) in AGB across plots. Measurement of AGB in the largest 5% of trees allows plot biomass to be predicted with ~85% precision. In contrast to rainforest in Africa and America, we show that a high proportion of species are capable of reaching a large-diameter in Australian wet tropical rainforest resulting in weak biomass hyperdominance (~10% of species account for 50% of the biomass) and high potential resilience to regional disturbances and global environmental change. We show that the high AGB in Australian tropical forests is driven primarily by the relatively high density of large trees coupled with contributions from significantly higher densities of medium size trees. Australian wet tropical rainforests are well positioned to maintain the current densities of large-diameter trees and high AGB into the future due to the species richness of large trees and a high density of replacement smaller trees.
Human Lung Epithelial Cells Divide >200 Population Doublings without Engaging a Telomere Maintenance Mechanism
Authors: Peters-Hall Jennifer R. , Min Jaewon , Tedone Enzo , Sho Sei , Siteni Silvia , Mender Ilgen , Shay Jerry W. 
Published: November 2018

AbstractThe “Hayflick limit” is a “mitotic clock” and primary cells have a finite lifespan that correlates with telomere length. However, introduction of the telomerase catalytic protein component (TERT) is insufficient to immortalize most, but not all, human cell types under typical cell culture conditions. Originally, telomerase activity was only detected in cancer cells but is now recognized as being detectable in transit amplifying cells in tissues undergoing regeneration or in extreme conditions of wound repair. Here we report thatin vitrolow stress culture conditions allow normal human lung basal epithelial cells to grow for over 200 population doublings without engaging any telomere maintenance mechanism. This suggests that most reported instances of telomere-based replicative senescence are due to cell culture stress-induced premature senescence.One Sentence SummaryHuman lung cells growing in reduced stress conditions can divide well beyond the Hayflick limit.
How VUCA is changing the learning landscape – and how curiosity can help
Authors: Horstmeyer Alison 
Published: November 2018

Purpose
This paper aims to describe four ways learning professionals can harness curiosity to navigate learning environments marked by volatility, uncertainty, complexity, and ambiguity (VUCA).

Design/methodology/approach
A review of theory and research on curiosity, VUCA, and learning and development challenges was conducted.

Findings
When applied to talent development, the attributes of curiosity (inquisitiveness, openness, creativity, and disruption tolerance) can help learning professionals innovate their offerings.

Practical implications
Organizational development and learning professionals are encouraged to implement measures for harnessing the power of curiosity within their processes to optimize their organizations’ learning programs.

Originality/value
VUCA has placed significant pressures on learning professionals to continually evolve employee development offerings to keep pace with dynamic organizational skill needs. Curiosity is presented as a plausible mechanism for enabling learning professionals to more successfully navigate these pressures.
Two-stage additive integer-valued data envelopment analysis models
Authors: Ajirlo Shahrooz Fathi , Amirteimoori Alireza , Kordrostami Sohrab 
Published: November 2018

Purpose
The purpose of this paper is to propose a modified model in multi-stage processes when there are intermediate measures between the stages and in this sense, the new efficiency scores are more accurate. Conventional data envelopment analysis (DEA) models disregard the internal structures of peer decision-making units (DMUs) in evaluating their relative efficiency. Such an approach would cause managers to lose important DMU information. Therefore, in multistage processes, traditional DEA models encounter problems when intermediate measures are used for efficiency evaluation.

Design/methodology/approach
In this study, two-stage additive integer-valued DEA models were proposed. Three models were proposed for measuring inefficiency slacks in each stage and in the system as a whole.

Findings
Three models were proposed for measuring inefficiency slacks in each stage and in the system as a whole.

Originality/value
The advantage of the proposed models for multi-stage systems is that they can accurately determine the stages with the greatest weaknesses/strengths. By introducing an applied case in the Iranian power industry, the paper demonstrated the applications and advantages of the proposed models.
Exploring the key performance indicators of green supply chain management in agro-industry
Authors: Gardas Bhaskar , Raut Rakesh , Jagtap Annasaheb H. , Narkhede Balkrishna 
Published: November 2018

PurposeThe issue of food security is one of the critical global challenges. The Government and the industries have begun apprehending the importance of green supply chain management (GSCM) implementation in their supply chains. There are various drivers or performance indicators (PIs) of GSCM in the agro-sector. This paper aims to analyse 14 PIs using an interpretive structural modelling (ISM) approach.Design/methodology/approachIn this study, the PIs of GSCM were identified through a literature survey and opinions of field experts. The identified 14 PIs were modelled by applying an ISM methodology for establishing the interrelationship between the PIs and to identify the PIs having high influential power.FindingsThe result of the investigation underlined that three PIs, namely, environmental management (PI 1), regulatory pressure (PI 3) and competitive pressure (PI 2) are the significant PIs having high driving power.Research limitations/implicationsThe experts’ judgments were used for the development of the structural model, which could be biased influencing the reliability of the model. Also, only 14 significant PIs were considered for the analysis. This research is intended to help the policymakers, managers and supply chain designers in the food industry and in agribusiness in formulating the policies and strategies for achieving food security, conservation of the environmental resources and for improving the financial performance of the industry.Originality/valueIt is pioneering research focusing on the analysis of the PIs towards the implementation of GSCM in the Indian agro-industries context using an ISM approach. This research adds value to the existing knowledge base by identifying the crucial PIs, exploring their mutual relationship and highlighting their level of influence in the case sector.
Doesn’t work as expectation
Authors: Wang Hongli 
Published: November 2018

PurposeThe purpose of this paper is to investigate the effects of “feeling trusted asymmetry” on work group performance and individual outcomes. The author adopts the term “feeling trusted asymmetry” to differentiate the subject from studies of trust asymmetry that consider differences in (mutual) ratings of trust between members of a dyad.Design/methodology/approachThe author tested this effectiveness with data from a sample of 293 subordinate–supervisor dyads in 63 work groups from the People’s Republic of China.FindingsResults of multilevel analysis reveal that group feeling trusted asymmetry (the degree to which subordinates differ in perceptions of the level of trust from their immediate manager in their group) lowers group performance. Furthermore, individual feeling trusted asymmetry (a subordinate perceiving more or less trust from their immediate manager than other subordinates in the group) affects employees’ workplace satisfaction, but not individual performance and creativity.Originality/valueThese findings have important practical implications, as they provide companies with a feasible way to manage employee’s relations based on their perception of trust from the direct supervisor.
From intangible resources to export performance
Authors: Rua Orlando Lima 
Published: November 2018

PurposeThe purpose of this paper is to analyse the influence of intangible resources on export performance, considering the mediating effect of absorptive capabilities and innovation.Design/methodology/approachThe authors use a quantitative research approach by conducting a quantitative study based on survey data from 247 Portuguese small- and medium-sized enterprises (SMEs) from the textile industry.FindingsFindings suggest that: Intangible resources has a positive, significant and direct influence on absorptive capabilities and on export performance; intangible resources has not a significant and direct influence on innovation and on the opposite direction absorptive capabilities has a positive, significant and direct influence on it; innovation has a positive, significant and direct influence on export performance, contrary to absorptive capabilities that has not a significant and direct influence; and innovation has a mediating effect on the relationship between intangible resources and export performance, and the same does not happens on the relationship between absorptive capabilities and export performance.Practical implicationsThis paper presents further evidences of the strategies that textile industry’s small firm managers should pursue, and policymakers should promote within the scope of the strategies associated to the system of tax benefits under negotiation for Portugal 2030.Originality/valueWhile previous authors have attempted to analyse certain aspects of this process (connection between intangible resources and export performance), this research developed a framework that combines these ones with the mediating effect of absorptive capabilities and innovation. This study deepens our understanding and provides novel insights into strategic management and innovation literature, since it combines multiple factors and has obtained the importance of each construct in SMEs business growth.
One gang dies, another gains? The network dynamics of criminal group persistence*
Authors: Ouellet Marie , Bouchard Martin , Charette Yanick 
Published: November 2018

AbstractWhat leads a minority of criminal groups to persist over time? Although most criminal groups are characterized by short life spans, a subset manages to survive extended periods. Contemporary research on criminal groups has been primarily descriptive and static, leaving important questions on the correlates of group persistence unanswered. By drawing from competing perspectives on the relationship between cohesion and group persistence, we apply a longitudinal approach to examine the network dynamics influencing the life span of criminal groups. We use 9 years of official data on the criminal and social networks of gang associates in Montreal, Quebec, Canada, to delineate criminal group boundaries and examine variation in group duration. Our statistical approach simultaneously considers within‐ and between‐group attributes to isolate how groups’ cohesion, as well as their embeddedness in the wider gang structure, impacts survival. Our results show that group survival is a function of their cohesion and embeddedness. Yet, the relationship is not direct but moderated by group size. Whereas large groups that adopt closed structures are more likely to persist, small groups’ survival depends on less cohesive and more versatile structures. In the discussion, we consider the impact of these findings for the continued understanding of group trajectories.
A novel KRT71 variant in curly‐coated dogs
Authors: Salmela E. , Niskanen J. , Arumilli M. , Donner J. , Lohi H. , Hytönen M. K. 
Published: November 2018

SummaryCurly fur is a common phenotype in many dog breeds, known to result from a missense variant (c.451C>T) in exon 2 of the keratin 71 (KRT71) gene. During screening for this variant across various breeds, we found that Curly Coated Retrievers (CCRs) fixed with the trait did not carry the known variant. By analysis of whole‐genome sequencing data of one CCR we identified a novel genetic cause for curly fur. We found a novel structural variant in exon 7 of the KRT71 gene (c.1266_1273delinsACA) that was predicted to result in a frameshift and stop loss, therefore significantly affecting the structure of the protein, if translated. The variant was also found at lower frequencies in five other breeds, including Lagotto Romagnolo, Bichon Frise, Spanish Water Dog, Chesapeake Bay Retriever and Irish Terrier. One curly‐coated Lagotto carried neither of the two KRT71 variants. These results identify a second variant for curly coat in KRT71 and suggest the existence of additional alleles. This study enables the development of an additional KRT71 gene test for breeders to understand and manage coat types.
How does studying rurally affect peer networks and resilience? A social network analysis of rural‐ and urban‐based students
Authors: Burgis‐Kasthala Sarath , Elmitt Nicholas , Moore Malcolm 
Published: November 2018

AbstractObjectiveTo examine differences in peer networks between urban‐based students and rural‐stream students in an Australian medical school and to examine how characteristics of networks relate to resilience.DesignCross‐sectional survey asking students to signify social, academic and support relationships with students in the same year and to complete a survey on their resilience.Setting and participantsAll second‐, third‐ and fourth‐year students at the Australian National University Medical School.Main outcome measuresSocial network analysis comparing peer networks, t‐test comparing mean resilience of urban and rural students.ResultsA visual analysis of the peer networks of year 2, 3 and 4 medical students suggests greater integration of rural‐stream students within the year 2 and 4 urban cohorts. Resilience is similar between year 2 and 3 students in both urban and rural streams, but is significantly higher in year 4 rural‐stream students, compared to their urban‐based peers. Networks of rural‐stream students suggest key differences between their period spent rurally and on their return and integration within the larger student cohort. Furthermore, rural students, once reintegrated, had larger and stronger social networks than their urban counterparts.ConclusionThe results of the study suggest that the rural experience can instruct support systems in urban settings. However, whether the rural placement creates a more resilient student or resilient students are selected for rural placement is unclear.
Caring for adults with congenital heart disease in a regional setting
Authors: O'Brien Emily Mary , Law David , Celermajer David , Grant Peter Watson , Waites Jon 
Published: November 2018

AbstractObjectiveThe number of adults with congenital heart disease has increased with improvements in surgical and medical management, posing a challenge for regional and rural settings, which might have difficulties accessing specialised professionals with congenital heart disease services. This study aims to ascertain the demographics and management of adults with congenital heart disease seen by a cardiology practice in regional Australia to better understand the needs of regional adults with congenital heart disease.DesignA descriptive study using data from clinical notes collected between April 2013 and April 2016.SettingA private cardiology practice in Coffs Harbour, New South Wales. The practice has a treating cardiologist, senior sonographer, visiting cardiothoracic surgeon and visiting paediatric cardiologist.ParticipantsOne‐hundred‐and‐one adults with congenital heart disease (age: 16–88 years; 55 women).Main outcome measuresCongenital heart disease defect, lesion severity, referral reason, past surgery, pulmonary hypertension, cardiac surgery during the study, mortality, adherence with follow‐up plans and specialist referral.ResultsSixty‐six patients had simple congenital heart disease, 24 had congenital heart disease of moderate complexity and 11 had congenital heart disease of great complexity. Most were referred for surveillance, seven were referred due to pregnancy and eight were new diagnoses. Six patients died, nine had cardiac operations and five were treated for pulmonary arterial hypertension. Overall adherence to the treating cardiologist's follow‐up plans was 84%. All patients with congenital heart disease of great complexity were referred to congenital heart disease specialists.ConclusionA substantial number of patients had complex pathology, new diagnoses or required surgery, highlighting the importance of developing integrated services with the close support of outside specialists in managing adults with congenital heart disease in regional settings.
“No One Cares if You Can't Work”: Injured and Disabled Mexican‐Origin Workers in Transnational Life Course Perspective
Authors: Unterberger Alayne 
Published: November 2018

AbstractWhat happens to injured immigrant workers as they age? What effects do their return migrations have on families, communities, and labor dynamics back home? This paper takes a composite of five immigrant families who participated in a long‐term binational study between Mexico and Florida, along with a separate cohort of Latino immigrant workers engaged in construction and warehousing in order to contextualize workers' health through Life Course Theory (LCT). This article specifically explores the lives of injured im/migrant workers and demonstrates the syndemic effects of Florida's lax workers' compensation (WC) system and intersecting health and labor policies and practices that exacerbate structural vulnerabilities on both sides of the U.S.–Mexico border. Syndemics combined with LCT highlights the intersecting and synergistic effects of place/environment, timing, timeline, and equity on health over the lifespan. Work‐related injuries, illnesses, and fatalities across different sectors of Florida's pro‐business economy exacerbate vulnerabilities and traumas, creating disability, and further inequalities in both the sending and receiving communities. The lack of effective workplace safety and health regulations perpetuate cycles of injury, illness, addiction, and precarity in both the United States and Mexico. These phenomena, combined with existing morbidities, fuel a binational disability syndemic that robs communities on both sides of the border of their economic, human, and social capital. Suggestions for different kinds of engagement and involvement by anthropologists and other social and health scientists are proposed, including discussions and examples of promising social movements attempting to hold Florida's food and agribusinesses accountable.