bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Longitudinal Three-Center Study of Dental Arch Relationship in Patients with Bilateral Cleft Lip and Palate
Authors: Bartzela Theodosia , Katsaros Christos , Shaw William C. , Rønning Elisabeth , Rizell Sara , Bronkhorst Ewald , Okada Terumi Ozawa , Pinheiro Fabio H. De S.L. , Dominguez-Gonzalez Susana , Hagberg Catharina , Semb Gunvor , Kuijpers-Jagtman Anne Marie 
Published: October 2018

Objective To compare and evaluate longitudinally the dental arch relationships from 4.5 to 13.5 years of age with the Bauru-BCLP Yardstick in a large sample of patients with bilateral cleft lip and palate (BCLP). Design Retrospective longitudinal intercenter outcome study. Patients Dental casts of 204 consecutive patients with complete BCLP were evaluated at 6,9, and 12 years of age. All models were identified only by random identification numbers. Setting Three cleft palate centers with different treatment protocols. Main Outcome Measures Dental arch relationships were categorized with the Bauru-BCLP yardstick. Increments for each interval (from 6 to 9 years, 6 to 12 years, and 9 to 12 years) were analyzed by logistic and linear regression models. Results There were no significant differences in outcome measures between the centers at age 12 or at age 9. At age 6, center B showed significantly better results ( p = .027), but this difference diminished as the yardstick score for this group increased over time (linear regression analysis), the difference with the reference category (center C, boys) for the intervals 6 to 12 and 9 to 12 years being 10.4% ( p = .041) and 12.9% ( p = .009), respectively. Conclusions Despite different treatment protocols, dental arch relationships in the three centers were comparable in final scores at age 9 and 12 years. Delaying hard palate closure and employing infant orthopedics did not appear to be advantageous in the long run. Premaxillary osteotomy employed in center B appeared to be associated with less favorable development of the dental arch relationship between 9 and 12 years.
Birth Weight, Body Length, and Cranial Circumference in Newborns with Cleft Lip or Palate
Authors: Becker Magnus , Svensson Henry , Källén Bengt 
Published: October 2018

Objective This paper reports on birth weight, body length, body mass index, and cranial circumference at birth of infants with cleft lip and/or palate born between 1973 and 1992. Methods Data were obtained from two nationwide swedish health registries. Infants with syndromes, twins, and infants with immigrant parentage were excluded from the study. Comparisons were made with all singleton births with the same exclusion criteria (n = 2,031,140). Results The body dimensions of infants with isolated cleft lip (n = 865) were found not to differ from those of control subjects, but infants with isolated cleft palate (n = 811) or cleft lip and palate (n = 1139) were found to be lighter and shorter than control subjects. Also, infants with the Pierre Robin sequence (n = 121) had a tendency to be lighter and shorter than control subjects, but these differences did not reach statistical significance despite the large study population.
Nasalance Distance and Ratio: Two New Measures
Authors: Bressmann Tim , Sader Robert , Whitehill Tara L. , Awan Shaheen N. , Zeilhofer Hans-Florian , Horch Hans-Henning 
Published: October 2018

Objectives Mean nasalance in speakers with perceptually normal nasal resonance can differ in magnitude considerably. In addition, categorizations of speech based on nasalance scores may not agree with perceptual judgments. To overcome this limitation, we evaluated two new simple measures derived from mean nasalance data: the nasalance distance (range between maximum and minimum nasalance) and the nasalance ratio (minimum nasalance divided by maximum nasalance). Setting Department of Oral and Maxillofacial Surgery, University of Technology, Munich, Germany. Subjects The sample consisted of 133 cleft lip and palate patients with normal nasal resonance or varying degrees of hypernasality. Procedures Oral and nasal acoustic measurements were made using the NasalView system. Nasalance distance and nasalance ratio were calculated for five nonnasal and three nasal sentences from the modified Heidelberg Rhinophonia Assessment Form. Results Optimum cutoffs were derived from Receiver-Operating Characteristics. Results for the sentence stimuli ranged from 64.4% to 89.6% sensitivity and from 91.2% to 94.1% specificity. When the analysis was limited to only one nonnasal and one nasal sentence, results ranged from 79.7% to 87.5% sensitivity and from 88.2% to 97.1% specificity. Conclusions We conclude that the two new measurements are valuable in routine clinical examinations. Nasalance distance and ratio derived from sentence stimuli are two useful and easily applicable measures that can be used to supplement the nasalance mean value.
The Craniofacial Dysostosis Syndromes: Current Surgical Thinking and Future Directions
Authors: Posnick Jeffrey C. , Ruiz Ramon L. 
Published: October 2018

Craniofacial dysostosis is the term applied to familial forms of craniosynostosis in which the sutural involvement generally includes the cranial vault, cranial base, and midfacial skeletal structures. The syndromic forms of craniofacial dysostosis (CFD) were initially described by Carpenter, Apert, Crouzon, Saethre and Chotzen, Pfeiffer, and others. In addition to the dysmorphic cranial features, affected individuals may have profound alterations in facial skeletal development. Surgical reconstruction requires thoughtfully sequenced and staged procedures with consideration for the individual's specific malformations, craniofacial growth patterns, and psychosocial needs. Management of the CFD syndromes is surgical, but the indications and the timing, type, and effectiveness of each stage of reconstruction have not been well evaluated and remains as much an art as a science. This article reviews the specific characteristic clinical features of the CFD syndromes and presents current philosophy and rationale for the staging of reconstruction.
Imaging of Cartilage and Mimic Muscles with MRI: Anatomic Study in Healthy Volunteers and Patients with Unilateral Cleft Lip and Palate
Authors: Kleinheinz Johannes , Joos Ulrich 
Published: October 2018

Objective: The aim of the study was to visualize different soft tissues in the perioral, nasal, and paranasal region by means of magnetic resonance imaging (MRI) in patients with unilateral cleft lip and palate (UCLP). Design: In this descriptive study, images of different MRI systems were assessed and compared. Method: MRI was applied in five consecutive patients operated on for UCLP who underwent secondary lip and nasal correction, two patients who had not had UCLP operations, and five healthy volunteers as controls. The mimic muscles, vessels, and nasal cartilages were evaluated. Results: It was possible to visualize different parts of the paranasal and perioral mimic muscles and their interlacement in the upper lip. The nasal cartilages were also visible, and the changes after operation were demonstrated. Conclusions: MRI shows differentiated visualization of soft tissues in the cleft region and their changes after surgery. It is a valuable tool in the preoperative planning and postoperative follow-up in patients with UCLP.
Dentocraniofacial Morphology of 12 Japanese Subjects with Unilateral Cleft Lip and Palate with a Severe Class III Malocclusion: A Cephalometric Study at the Pretreatment Stage of Surgical Orthodontic Treatment
Authors: Tateishi Chizu , Moriyama Keiji , Takano-Yamamoto Teruko 
Published: October 2018

Objective: The present study clarifies the dentocraniofacial morphology of patients with cleft lip and palate (CLP) with severe Class III malocclusion prior to surgical orthodontic treatment. Methods: The sample was 12 Japanese male subjects with repaired complete unilateral CLP (surgical CLP group; 21.2 ± 1.92 years in mean age). Two sets of patients without CLP Class III malocclusion, consisting of 19 male subjects treated by surgical orthodontic treatment (surgical Class III group; 23.4 ± 6.35 years in mean age) and 14 male subjects treated by nonsurgical orthodontic treatment (nonsurgical Class III group; 18.7 ± 3.49 years in mean age) were used as controls. Analyses were performed using lateral and posteroanterior (P-A) cephalograms. Results: (1) The surgical CLP group showed significantly smaller values for overjet, SNA angle, and inclination of the maxillary incisor as compared with those of the surgical and nonsurgical Class III controls. The values of SNB, mandibular effective length, and ramus height in the surgical CLP group were significantly smaller than those of the surgical Class III group but were similar to those of the nonsurgical Class III group. (2) The mandible and the upper and lower dental arches deviated laterally toward the cleft side. The displacement of the mandible was correlated with that of the maxilla. These results show that CLP patients who required surgical orthodontic treatment had a characteristic dentocraniofacial morphology, compared to controls without CLP with Class III malocclusion.
Nasalance Measures in Marathi Consonant-Vowel-Consonant Syllables with Pressure Consonants Produced by Children with and without Cleft Lip and Palate
Authors: Nandurkar Aparna 
Published: October 2018

Objective The purpose of this study was to ascertain whether there exist differential nasalance measures for consonant-vowel-consonant syllables consisting of different pressure consonants articulated by Marathi-speaking children with and without repaired cleft lip and palate. Participants Ten Marathi-speaking children with repaired cleft palate between the ages of 5 and 12 years formed the experimental group. The control group consisted of 10 age- and sex-matched children with no clefts and no history of any hearing, speech, or voice disorder. Methods and Materials The Kay Elemetrics nasometer model 6200-2 (IBMPC version) was used for obtaining nasalance measurements. Speech material consisted of eight Marathi monosyllabic words consisting of the pressure consonants p, t, k, s, ∫, h, t∫, dz in the initial position. The correlation between perceptual judgments of nasality and the instrumental measures was studied by computing the Phi coefficient. Results Results indicate that there exist differential mean nasalance scores for the syllables with different pressure consonants articulated by Marathispeaking subjects with repaired cleft lip and palate and those without cleft lip and palate. Correlation coefficient computed between the instrumental measures and the perceptual judgments of nasality indicates moderate correlation between the two measures. Conclusions Presence of differential nasalance scores may have diagnostic and therapeutic implications. Results also emphasize the need to evaluate nasal resonance in stimuli other than the traditional ones.
Magnetic Resonance Imaging of the Levator Veli Palatini Muscle during Speech
Authors: Ettema Sandra L. , Kuehn David P. , Perlman Adrienne L. , Alperin Noam 
Published: October 2018

Objective To obtain detailed anatomic information on the levator veli palatini (LVP) muscle from magnetic resonance imaging (MRI). Quantitative measures of the configuration of the LVP muscle at rest and during speech activities were obtained. Design Prospective study using MRI of adult subjects with normal velopharyngeal mechanisms to determine anatomic and physiologic parameters of the levator muscle. The levator veli palatini muscle was imaged at rest and during speech activities consisting of nasal and nonnasal sounds mixed with vowels, consonants, or both (e.g., /ansa, asna, amfa, afma/). Participants Ten normal healthy adults (five men, five women) between 21 and 53 years of age and free of oropharyngeal abnormalities. Main outcome Measures Two-dimensional spin echo static images and dynamic fast gradient echo images of the levator muscle in both the sagittal and oblique/coronal planes. Results On average across female (F) and male (M) subjects: distance between LVP muscle origin points, 52.6 mm (F), 54.6 mm (M); angle of levator muscle origin at rest, 64.5° (F), 60.4° (M); length of the levator muscle at rest, 44.1 mm (F), 46.4 mm (M); width of levator muscle at lateral margin of velum, 5.5 mm (F), 6.6 mm (M). Both the levator muscle angle of origin and length became progressively smaller from rest, nasal consonants, low vowels, high vowels, and fricatives for both female and male subjects. Across all subjects, there was a 19% reduction in length of the LVP muscle from rest position to fricative production. Conclusions MRI is an effective method of imaging and measuring the LVP muscle and related structures in living subjects. Understanding the normal tissue distribution and quantification of the LVP muscle provides important information for development of a functional biomechanical model of the velopharynx and for improved surgical treatment.
Pressure-Flow Measurements for Selected Nasal Sound Segments Produced by Normal Children and Adolescents
Authors: Smith Bonnie E. , Guyette Thomas W. , Patil Yash , Brannan Timothy S. 
Published: October 2018

Objective The purpose of this prospective study was to: (1) report simultaneous oral-nasal pressures, nasal airflow rates, and velopharyngeal orifice areas for nasal sounds produced by children and adolescents; (2) determine whether data could be statistically classified by age, sex, or utterance type; and (3) provide guidelines for determining typical from atypical productions. Participants The study involved 56 subjects, with two boys and two girls representing each age from 5 to 18 years. Subjects had no history of speech therapy, were judged as having normal speech and resonance at the time of testing, and had no upper respiratory tract infections or allergies at the time of testing. Methods All subjects repeated /ma/ and “hamper” at normal pitch and loudness after an examiner model. Mean oral-nasal pressures, nasal airflow rates, and velopharyngeal orifice areas were calculated for each subject's utterances. A discriminate function analysis determined whether data could be grouped by age and sex. Results Significant differences in mean data for age groups of 5 to 9 years, 10 to 13 years, and 14 to 18 years were observed. Data showed decreases in pressures and increases in nasal airflow and orifice areas with age. Variability in pressure stayed consistent or decreased with age, but variability in nasal airflow and orifice areas increased with age. Conclusions We propose a scheme for categorizing velopharyngeal function for oral and nasal sound production to be used in clinical testing.
Repair of Congenital Nasal Anomalies Involving Redundancy of Structures
Authors: Zbar Ross I. S. , Rai Shankar Man , Ghimire Pradeep 
Published: October 2018

Objective Rare congenital nasal anomalies include symmetric complete nasal duplication and asymmetric supernumerary nostrils. Complete nasal duplication may be either vertically stacked or horizontally oriented. It is a result of duplication of the nasal placode pair. Supernumerary structures include nostrils (with or without accessory cartilage) or fistulas that result from a fissure of the lateral nasal process. A case report is described whereby an adult accessory nostril, complete with an extra lower lateral cartilage, is repaired through direct excision and tip suturing. The importance of removing superfluous structures and reconstructing the normal anatomy by using an open rhinoplasty technique is stressed to achieve an aesthetic outcome.
Preliminary Report of Two-Stage Secondary Alveolar Bone Grafting for Patients with Bilateral Cleft Lip and Palate
Authors: Kamakura S. , Yamaguchi T. , Kochi S. , Sato A. , Motegi K. 
Published: October 2018

Objective To overcome the difficulties of one-stage secondary alveolar bone grafting for patients with bilateral cleft lip and palate (BCLP) who have a broad alveolar cleft, the value of two-stage alveolar bone grafting was examined. Patients Three patients (2 girls and 1 boy) with BCLP were treated by two-stage alveolar bone grafting. The procedure consisted of a first-stage surgery (mean age 8 year 6 months ± 7.8 months), which consisted of alveolar bone grafting for one side of the BCLP, and second-stage surgery for the contralateral side several months later. For the postoperative assessment, radiographs of the operated site were examined. Results The average amount of implanted bone per operation and per patient was 6.8 ± 1.1 g and 13.7 ± 1.0 g, respectively. Postoperative clinical and radiographic examinations revealed that an appreciable alveolar bone ridge had formed, and there were no major complications. Conclusions Two-stage alveolar bone grafting, which makes it possible to reduce the amount of implanted bone, could be an optional surgical procedure for patients with BCLP and a broad alveolar cleft.
Alternative Impression Technique for a Speech-Aid Prosthesis
Authors: Keyf Filiz , Sahin Nesrin , Aslan Yavuz 
Published: October 2018

Objective Prosthetic treatment for speech disorders attributable to surgically acquired soft palate defects are introduced. Case A patient who underwent soft palate resection for cancer is presented. The resected portion of the soft palate was confined to the posterior segments. A prosthesis with a speech bulb was adapted to the patient. Conclusion Excellent restoration of speech and improvement of velopharyngeal function was achieved following placement of the special prosthesis.
Исследование загрузочных свойств монолитных колонок для ВЭЖХ на основе пористых органических полимеров
Authors: Патрушев Ю. В. , Юдина Ю. С. , Сидельников В. Н. 
Published: October 2018

Исследованы загрузочные свойства монолитных хроматографических колонок для ВЭЖХ с сорбентами на основе 1-винилимидазола и 4-винилпиридина. Проведено сравнение загрузочных свойств данных колонок с коммерческой микронасадочной колонокй Диасфер-250-СТ. Показано, что при составе элюента ацетонитрил/вода, равном 60/40 величины загрузок для монолитных колонок выше, чем для насадочной колонки с аналогичными габаритами. При составе элюента ацетонитрил/вода, равном 20/80 величины загрузок для монолитных колонок и для насадочной колонки примерно одинаковы.
Кислотно-основные и адсорбционные свойства пористого микродисперсного детонационного наноалмаза
Authors: Ланин С. Н. , Рычкова С. А. , Виноградов А. Е. , Вирясов М. Б. , Власенко Е. В. , Ланина К. С. , Нестеренко П. Н. , Хохлова Т. Д. 
Published: October 2018

Исследована адсорбция ряда соединений, обладающих свойствами кислот, оснований и амфотерных соединений, на пористом микродисперсном детонационном наноалмазе (ПМДН) из водных растворов. Из анализа результатов адсорбции кислотных и основных красителей на поверхности ПМДН следует, что на поверхности сорбента имеются как основные, так и кислотные группы, с которыми способны вступать во взаимодействия молекулы органических кислот, оснований и амфотерных соединений. Обработка исходного образца кислотой или основанием приводит к уменьшению адсорбции кислотных и основных красителей, что может быть связано с удалением примесей с поверхности ПМДН, с которыми способны взаимодействовать кислотные и основные соединения.
Исследование пористой структуры активного угля из рисовой шелухи
Authors: Вин Мьинт Со , Тху Аунг Си , Клушин В. Н. , Нистратов А. В. , Киреев С. Г. , Мухин В. М. 
Published: October 2018

Методом низкотемпературной адсорбции азота исследована пористая структура активного угля из рисовой шелухи. Установлено, что при парогазовой активации первичная пористость карбонизата, представленная ультрамикропорами с максимумом при ~ 0.68 нм, супермикропорами с максимумом ~ 1.1 нм и мезопорами с максимумом ∼ 3 нм, развивается в направлении радиального выгорания ультрамикропор со смещением максимума распределения в сторону увеличения размеров, полного выгорания супермикропор и двукратным ростом объема мезопор.
Сорбционное концентрирование α-аминокислот сополимерами 1-винил-3,5-диметилпиразола с этиленгликольдиметакрилатом
Authors: Кузнецов В. А. , Лавлинская М. С. , Хохлов В. Ю. , Шаталов Г. В. 
Published: October 2018

Изучены сорбционные свойства новых сетчатых сополимеров на основе 1-винил-3,5-диметилпиразола и этиленгликольдиметакрилата по отношения к α-аминокислотам – гистидину и триптофану – в статических и динамических условиях при различных значениях pH. Установлено, что предложенные сорбенты характеризуются высокими значениями степеней концентрирования, малым временем извлечения по отношению к аминокислотам, что позволяет использовать их для сорбционного концентрирования гистидина и триптофана. На основании проведенных исследований разработана методика сорбционно-спектрофотометрического определения гистидина и триптофана в водных растворах.
Сорбция синтетических красителей полимерами с молекулярными отпечатками
Authors: Зяблов А. Н. , Хальзова С. А. , Дуванова О. В. , Селеменев В. Ф. , Козлов А. Т. 
Published: October 2018

Получены изотермы сорбции синтетических красителей полимерами с молекулярными отпечатками и их полимеров сравнения. Определены значения максимальной сорбционной емкости сорбентов по отношению к красителям. Рассчитаны значения степеней извлечения и коэффициентов распределения, определен импринтинг-фактор. Установлено, что полимеры с молекулярными отпечатками на основе полиимида обладают лучшей сорбционной способностью по отношению к целевым молекулам, чем их полимеры сравнения.
Активность глутатионредуктазы при патологических состояниях печени и очистка фермента с применением ионообменной хроматографии для исследования каталитических свойств
Authors: Попов С. С. , Агарков А. А. , Крыльский Е. Д. , Шульгин К. К. , Попова Т. Н. , Сафонова О. А. 
Published: October 2018

Выявлено возрастание активности глутатионредуктазы в сыворотке крови больных неалкогольным стеатогепатитом, развивающимся при сахарном диабете 2 типа, и лекарственным гепатитом, а также в сыворотке и печени крыс при экспериментальном токсическом гепатите. Для исследования каталитических свойств фермента была проведена его очистка из печени крыс контрольной группы иживотных с индуцированным токсическим гепатитом с применением ионообменной хроматографии. С использованием полученных ферментных препаратов выявлены различия в регуляции активности глутатионредуктазы под действием глюкозо-6-фосфата и рибозо-5-фосфата, что, очевидно, связано с конформационными модификациями молекулы фермента в условиях оксидативного стресса, развивающегося при патологии
Синтез и адсорбционные свойства сорбентов ограниченного доступа на базе сверхсшитого полистирола
Authors: Блинникова З. К. , Попов А. Ю. , Цюрупа М. П. , Даванков В. А. 
Published: October 2018

Разработаны особые условия суспензионной сополимеризации стирола с дивинилбензолом, позволяющие уменьшить размер гранул до 30-60 мкм и существенно сузить распределение гранул по диаметру. Полученный в этих условиях сополимер с 0.7% дивинилбензола был сшит монохлордиметиловым эфиром до степени сшивания 100 и 200%. Сорбенты в статических условиях извлекают 83-95% фенилкарбоновых кислот из водного разбавленного подкисленного раствора. Десорбция кислот щелочным метанолом близка к 100%. Сорбенты не поглощают альбумин. Принадлежность сорбентов к классу материалов ограниченного доступа продемонстрирована также на примере полного разделения методом ВЭЖХ смеси плазмы, лекарства Амперозид, его метаболита и родственных соединений, при этом белки плазмы не удерживались и выходили с мертвым объемом.
Скрининг продуктов трансформации 1,1-диметилгидразина на поверхности шунгита методом масс-спектрометрии МАЛДИ
Authors: Карнаева А. Е. , Ярцев С. Д. , Полунина И. А. , Буряк А. К. 
Published: October 2018

Методом масс-спектрометрии с лазерной десорбцией/ионизацией (МАЛДИ) исследованы продукты окислительной трансформации 1,1-диметилгидразина. Показано, что из водных растворов на минеральном шунгите наиболее эффективно сорбируются относительно высокомолекулярные продукты трансформации 1,1-диметилгидразина. Сорбция наиболее токсичного продукта его трансформации – нитрозодиметиламина – происходит значительно быстрее из раствора в пиридине, чем из воды.