bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-efficacy beliefs of medical students: a&nbsp;critical review
Authors: Klassen Robert M. , Klassen Joel R. L. 
Published: February 2018

Introduction Self-efficacy is a theoretically and empirically robust motivation belief that has been shown to play an important role in the learning and development of new skills and knowledge. In this article, we critically review research on the self-efficacy beliefs of medical students, with a goal to evaluate the existing research and to strengthen future work. In particular, we sought to describe the state of research on medical student self-efficacy and to critically examine the conceptualization and measurement of the construct. Finally, we aimed to provide directions for future self-efficacy research.
Methods We critically reviewed 74 published articles that included measures of self-efficacy beliefs of medical students.
Results Our review showed that (a) research on the self-efficacy beliefs of medical students is growing and is becoming increasingly international, and (b) that nearly half (46%) of self-efficacy measures showed conceptual and operational flaws.
Discussion Our critical review of 74 research studies on self-efficacy of medical students found that although research in the field is increasing, nearly half of measures labelled as self-efficacy were incongruent with the conceptual guidelines set by self-efficacy experts. We provide five suggestions for future research on the self-efficacy of medical students.
Changes in Rehabilitation Outcomes by new Guidelines of Hong Kong Hospital Authority in Implant Choice for Femoral Neck Fractures—Austin Moore versus Cemented Exeter Hemiarthroplasty
Authors: Yung-Chak Hsu Albert 
Published: February 2018

Background In 2013, Hospital Authority of Hong Kong replaced Austin Moore Arthroplasty (AMA) with cemented Exeter hemiarthroplasty for displaced femoral neck fractures. This study evaluated whether this new guidelines resulted in better mortality, hospital service reattendances and rehabilitation outcomes. Methods Patients aged 65–84 years with hemiarthroplasty done in a tertiary hospital during 2012–2014 were reviewed retrospectively. AMA group included AMAs carried out during years 2012–2013, and Exeter group included cemented modular Exeter hemiarthroplasties carried out during years 2013–2014. All patients were followed-up for 2 years. Results The Exeter group performed significantly better in rehabilitation outcomes than AMA group in terms of mobility score, independent and outdoor walking and community dwelling. They also had less hospital service reattendances due to falls, refractures and implant-related causes. There was a trend towards lower mortality in the Exeter group with increasing duration from operation. Conclusion The new guidelines in replacing AMA with cemented Exeter hemiarthroplasty resulted in better patient outcomes.
Avaliação por imagem do púbis em jogadores de futebol
Authors: Todeschini Karina , Daruge Paulo , Bordalo-Rodrigues Marcelo , Pedrinelli André , Busetto Antonio Marcos 
Published: February 2018

Resumo
Objetivo Comparar a acurácia da ultrassonografia em relação à ressonância magnética na detecção de lesões da aponeurose do reto abdominal/adutor longo, estudar características dos jogadores e achados de imagem associados à pubalgia e demonstrar a importância de cada método.
Materiais e métodos Estudo realizado de 2011 a 2016 com 39 jogadores profissionais de futebol, 15 deles com e 24 sem pubalgia. Foram registrados idade, posição, índice de massa corporal (IMC), carga de treino semanal, tempo de profissão e lesão prévia na coxa/joelho e lombalgia. Os seguintes exames de imagem foram realizados: radiografias (anteroposterior da bacia e flamingo) para avaliar sinais de impacto do quadril, articulações sacroilíacas e instabilidade da sínfise púbica; ultrassonografia para analisar a aponeurose comum do reto abdominal/adutor longo e hérnias inguinais e do esporte; ressonância magnética buscando alterações degenerativas e edema no púbis, lesões musculares dos adutores e retos abdominais e na sua aponeurose.
Resultados Observou-se uma associação entre pubalgia e IMC elevado (p = 0,032) e alterações musculares (p < 0,001). Hérnia inguinal foi encontrada em dois casos e hérnia do esporte, em um caso e dois controles. Alterações degenerativas do púbis foram frequentes nos dois grupos. Lesões da aponeurose foram mais comuns nos pacientes com dor e a ultrassonografia teve sensibilidade de 44,4% e especificidade de 100% na detecção.
Conclusão A avaliação da pubalgia atlética deve ser realizada com radiografias, ultrassonografia e ressonância magnética. Índice de massa corporal elevado, lesões musculares, geodos e osteófitos são achados associados à pubalgia; a ultrassonografia tem baixa sensibilidade para detectar lesões da aponeurose comum do reto abdominal/adutor longo.
Efeito comparativo entre a infiltração de plasma rico em plaquetas e o uso de corticosteroides no tratamento de osteoartrite do joelho: Estudo clínico prospectivo e randomizado
Authors: Freire Marianna Ribeiro de Menezes , da Silva Philippe Mota Coutinho , Azevedo Arthur Rangel , Silva Denison Santos , da Silva Ronald Bispo Barreto , Cardoso Juliana Cordeiro 
Published: February 2018

Resumo
Objetivo Analisar a eficácia do uso de plasma rico em plaquetas, obtido do sangue periférico e autólogo dos pacientes, na redução das queixas álgicas e melhoria funcional dos pacientes portadores de osteoartrite de joelhos, em comparação com o tratamento padrão com injeção de corticosteroides de depósito, como a triancilonola.
Métodos Os pacientes foram acompanhados clinicamente na consulta pré-infiltrativa, com avaliação quantitativa através das escalas Knee Society Score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), e Kellgren and Lawrence. Além disso, os pacientes foram reavaliados com as mesmas escalas após 1 mês e 6 meses de intervenção com 2,5 mL de acetato de triancinolona ou 5 mL de plasma rico em plaquetas. O estudo foi feito em 50 pacientes portadores de osteoartrite de joelhos atendidos no Centro de Especialidades Médicas, divididos em amostras equivalentes randomizadas para cada terapia.
Resultados No presente estudo, verificaram-se redução dos valores em escalas álgicas, como a WOMAC, e elevação das pontuações em escalas funcionais, como a KSS, evidenciadas em 180 dias após o uso de plasma rico em plaquetas, uma terapia feita a partir do sangue autólogo do paciente e com menos efeitos colaterais.
Conclusão Embora ambas as terapias com plasma rico em plaquetas e corticosteroides tenham se mostrado eficazes na redução das queixas álgicas e na recuperação funcional, houve diferença significativa entre as terapias aos 180 dias. De acordo com os resultados obtidos, no tratamento da osteoartrite do joelho, o plasma rico em plaquetas demonstrou efeitos mais duradouros em 180 dias.
Judicial Discretion and the Minimum Statutory Sentence for Migrant Smuggling through Indonesia
Authors: PALMER Wayne , MISSBACH Antje 
Published: February 2018

AbstractThe general, but false, perception of migrant smuggling through Indonesia, a large, archipelagic country, is that smugglers operate entirely on their own. In fact, the more complex smuggling operations rely on broad networks of foreign organizers as well as local intermediaries and ground staff. In 2011, the Indonesian legislature introduced a severe minimum sentence for any involvement in migrant smuggling with the expectation that the judiciary would apply the sentence in all future cases. However, some judges proceeded to hand down sentences below the statutory minimum, arguing that the punishment is not commensurate to the relatively minor roles played by locals. This article examines how judges at all levels of the judiciary did so in ten related cases. In conclusion, it argues that statutory sentences are not mandatory in Indonesia and that, by applying below-minimum sentences, judges not only maintain judicial independence; they also effectively exercise a judicial review function.
Prediction of near-wall turbulence using minimal flow unit
Authors: Yin Guang , Huang Wei-Xi , Xu Chun-Xiao 
Published: February 2018

In the present study, direct numerical simulation (DNS) is carried out in a minimal channel at $Re_{\unicode[STIX]{x1D70F}}=2000$ to sustain healthy turbulence below $y^{+}=100$. Turbulence intensities are compared with those of the motions at the same scales as the minimal channel in the full-sized channel at $Re_{\unicode[STIX]{x1D70F}}=2003$ (Hoyas & Jiménez, Phys. Fluids, vol. 20 (10), 2008, article 101511). They show good agreement in $y^{+}<100$. The universal signals for the three velocity components similar to that in the predictive model of Marusic et al. (Science, vol. 329 (5988), 2010, pp. 193–196) are extracted from the DNS data of the full-sized channel. They correspond well to the near-wall velocity fluctuations in the minimal flow unit (MFU). The predictive models for the three components of near-wall velocity fluctuations are proposed based on the MFU data. The predicted turbulence intensities as well as the joint probability density functions of velocity fluctuations agree well with the DNS results of the full-sized channel turbulence.
Curtailing data biases in business research: Introducing a hybrid approach
Authors: Alam Muhammad Aftab , Bhatti Omar Khalid 
Published: February 2018

AbstractThis study elucidates the falsity of business research in relying on either respondents or informants alone for data collection, and argues that with the biased data, business research cannot provide unbiased solutions. We compare 400 reports (200 respondents and 200 informants) on the workplace deviance and assess the goodness of both the techniques. Analysis of variance andposthoc(descriptive discriminant analysis) indicate significant disparities between the two approaches across all items. In the informant’s role, people tend to overreport, whereas in the respondent’s part they underreport an undesirable behavior. Further, we find that conventional techniques for assessing the construct’s validity and common-method bias neither assures realistic measurement nor eliminate the response bias. Drawing on the theory of psychological projection, we propose a hybrid approach that curtails some of the main biases in data and measurement. Qualitative confirmation through informal interviews with managers in the investigated firms validates the proposed method.
THE POPULARITY OF ANCIENT HISTORIANS, 1450–1600
Authors: JENSEN FREYJA COX 
Published: February 2018

AbstractThe histories of ancient Greece and Rome are part of a shared European heritage, and a foundation for many modern Western social and cultural traditions. Their printing and circulation during the Renaissance helped to shape the identities of individual nations, and create different reading publics. Yet we still lack a comprehensive understanding of the forms in which works of Greek and Roman history were published in the first centuries of the handpress age, the relationship between the ideas contained within these texts and the books as material objects, and thus the precise nature of the changes they effected in early modern European culture and society. This article provides the groundwork for a reassessment of the place of ancient history in the early modern world. Using new, digital resources to reappraise existing scholarship, it offers a fresh evaluation of the publication of the ancient historians from the inception of print to 1600, revealing important differences that alter our understanding of particular authors, texts, and trends, and suggesting directions for further research. It also models the research possibilities of large-scale digital catalogues and databases, and highlights the possibilities (and pitfalls) of these resources.
Fitness and eco-physiological response of a chytrid fungal parasite infecting planktonic cyanobacteria to thermal and host genotype variation
Authors: Agha Ramsy , Gross Alina , Gerphagnon Melanie , Rohrlack Thomas , Wolinska Justyna 
Published: February 2018

AbstractUnderstanding how individual parasite traits contribute to overall fitness, and how they are modulated by both external and host environment, is crucial for predicting disease outcome. Fungal (chytrid) parasites of phytoplankton are important yet poorly studied pathogens with the potential to modulate the abundance and composition of phytoplankton communities and to drive their evolution. Here, we studied life-history traits of a chytrid parasite infecting the planktonic, bloom-forming cyanobacteriumPlanktothrixspp. under host genotype and thermal variation. When expressing parasite fitness in terms of transmission success, disease outcome was largely modulated by temperature alone. Yet, a closer examination of individual parasite traits linked to different infection phases, such as (i) the establishment of the infection (i.e. intensity of infection) and (ii) the exploitation of host resources (i.e. size of reproductive structures and propagules), revealed differential host genotype and temperature × host genotype modulation, respectively. This illustrates how parasite fitness results from the interplay of individual parasite traits that are differentially controlled by host and external environment, and stresses the importance of combining multiple traits to gain insights into underlying infection mechanisms.
Approaching Custom Identification as a Conflict Avoidance Technique:TadićandKupreškićRevisited
Authors: GALAND ALEXANDRE SKANDER 
Published: February 2018

AbstractInternational human rights law (IHRL), international humanitarian law (IHL) and international criminal law (ICL) have trouble staying faithful to the two pillars of customary international law – state practice andopinio juris. In ICL, theTadićInterlocutory Appeal on Jurisdiction and theKupreškićTrial Judgement have even gone as far as enunciating new models to identify customs. In this article, I show that the approaches to customs’ identification postulated in these two cases were conflict-avoidance techniques used by the International Criminal Tribunal for the Former Yugoslavia (ICTY) to bring together IHRL and IHL. The crux of the matter in theTadićandKupreškićcases was that the human rights of the victims of war crimes committed in internal conflicts required that a new approach to customary international law be adopted. Thus, the criminal aspect of IHL (i.e., ICL) was updated, and conceptual conflicts between IHL and IHRL were avoided.
Ring filter synthesis and its BiCMOS 60 GHz implementation
Authors: Rynkiewicz Pedro , Franc Anne-Laure , Coccetti Fabio , Wietstruck Matthias , Wipf Christian , Tolunay Wipf Selin , Kaynak Mehmet , Prigent Gaëtan 
Published: February 2018

AbstractThe detailed synthesis of a direct access ring filter topology fully controlled with the following targeted specification (center frequency, low transmission zero frequency, and matching level in the passband) is hereby presented. For this topology, the lowest achievable bandwidth is limited by technological constraints. Thereby a solution consisting in adding capacitive loads is proposed. The associated synthesis is also given and discussed. Both syntheses are illustrated with 60 GHz integrated planar filters implemented in the IHP 130 nm BiCMOS technology. Various 3 dB fractional bandwidths from 18 to 8% are targeted, some of them require the implementation of the capacitive loaded solution. The latter allows us to lower the bandwidth limit of the nominal topology as well as to get a high miniaturization, up to 3.4, depending on the capacitance value. Thanks to good measurement results, this implementation highlights the high efficiency, reliability, and versatility of the synthesis without the need of tuning simulations or post-simulations.
Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling
Authors: Bartelt Alexander , Behler-Janbeck Friederike , Beil F. Timo , Koehne Till , Müller Brigitte , Schmidt Tobias , Heine Markus , Ochs Laura , Yilmaz Tayfun , Dietrich Martin , Tuckermann Jan P. , Amling Michael , Herz Joachim , Schinke Thorsten , Heeren Joerg , Niemeier Andreas 
Published: February 2018

AbstractSkeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1 (Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass. Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand (RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor (PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.
Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia
Authors: Li Zhiming , Chen Shuai , Yang Yufeng , Zhuang Xuan , Tzeng Chi-Meng 
Published: February 2018

AbstractThe objective of this study was to identify genes regulated by methylation that were involved in spermatogenesis failure in non-obstructive azoospermia (NOA). Testis biopsies of patients with NOA and OA (with normal spermatogenesis) were evaluated by microarray analysis to examine DNA methylation and mRNA expression using our established integrative approach. Of the coordinately hypermethylated and down-regulated gene list, zinc-finger CCHC-type containing 13 (ZCCHC13) was present within the nuclei of germ cells of testicular tissues according immunohistochemistry, and there was decreased protein expression in men with NOA compared with OA controls. Mechanistic analyses indicated that ZCCHC13 increased c-MYC expression through the p-AKT and p-ERK pathways. To confirm the changes inZCCHC13expression in response to methylation, 5-aza-2′-deoxycitidine (5-Aza), a hypomethylating agent, was administered to mouse spermatogonia GC-1 cells. We demonstrated that 5-Aza enhanced protein and mRNA expression ofZCCHC13epigenetically, which was accompanied by activation of p-AKT and p-ERK signaling. Our data, for the first time, demonstrate that ZCCHC13 is an important signaling molecule that positively regulates the AKT/MAPK/c-MYC pathway and that methylation aberrations ofZCCHC13may cause defects in testis development in human disease, such as NOA.
A peptide tag-specific nanobody enables high-quality labeling for dSTORM imaging
Authors: Virant David , Traenkle Bjoern , Maier Julia , Kaiser Philipp D. , Bodenhöfer Mona , Schmees Christian , Vojnovic Ilijana , Pisak-Lukáts Borbála , Endesfelder Ulrike , Rothbauer Ulrich 
Published: February 2018

AbstractDense fluorophore labeling without compromising the biological target is crucial for genuine super-resolution microscopy. Here we introduce a broadly applicable labeling strategy for fixed and living cells utilizing a short peptide tag-specific nanobody (BC2-tag/bivBC2-Nb). BC2-tagging of ectopically introduced or endogenous proteins does not interfere with the examined structures and bivBC2-Nb staining results in a close-grained fluorophore labeling with minimal linkage errors. This allowed us to perform high-quality dSTORM imaging of various targets in mammalian and yeast cells. We expect that this versatile strategy will render many more demanding cellular targets amenable to dSTORM imaging.
Ultraslow isomerization in photoexcited gas-phase carbon cluster $${{\rm C}}_{10}^ -$$
Authors: Saha K. , Chandrasekaran V. , Heber O. , Iron M. A. , Rappaport M. L. , Zajfman D. 
Published: February 2018

AbstractIsomerization and carbon chemistry in the gas phase are key processes in many scientific studies. Here we report on the isomerization process from linear $${{\rm C}}_{10}^ -$$

C

10

-

to its monocyclic isomer. $${{\rm C}}_{10}^ -$$

C

10

-

ions were trapped in an electrostatic ion beam trap and then excited with a laser pulse of precise energy. The neutral products formed upon photoexcitation were measured as a function of time after the laser pulse. It was found using a statistical model that, although the system is excited above its isomerization barrier energy, the actual isomerization from linear to monocyclic conformation takes place on a very long time scale of up to hundreds of microseconds. This finding may indicate a general phenomenon that can affect the interstellar medium chemistry of large molecule formation as well as other gas phase processes.
Decomposing the Bragg glass and the peak effect in a Type-II superconductor
Authors: Toft-Petersen Rasmus , Abrahamsen Asger B. , Balog Sandor , Porcar Lionel , Laver Mark 
Published: February 2018

AbstractAdding impurities or defects destroys crystalline order. Occasionally, however, extraordinary behaviour emerges that cannot be explained by perturbing the ordered state. One example is the Kondo effect, where magnetic impurities in metals drastically alter the temperature dependence of resistivity. In Type-II superconductors, disorder generally works to pin vortices, giving zero resistivity below a critical current jc. However, peaks have been observed in the temperature and field dependences of jc. This peak effect is difficult to explain in terms of an ordered Abrikosov vortex lattice. Here we test the widespread paradigm that an order-disorder transition of the vortex ensemble drives the peak effect. Using neutron scattering to probe the vortex order in superconducting vanadium, we uncover an order-disorder transition from a quasi-long-range-ordered phase to a vortex glass. The peak effect, however, is found to lie at higher fields and temperatures, in a region where thermal fluctuations of individual vortices become significant.
A mechanism for CO regulation of ion channels
Authors: Kapetanaki Sofia M. , Burton Mark J. , Basran Jaswir , Uragami Chiasa , Moody Peter C. E. , Mitcheson John S. , Schmid Ralf , Davies Noel W. , Dorlet Pierre , Vos Marten H. , Storey Nina M. , Raven Emma 
Published: February 2018

AbstractDespite being highly toxic, carbon monoxide (CO) is also an essential intracellular signalling molecule. The mechanisms of CO-dependent cell signalling are poorly defined, but are likely to involve interactions with heme proteins. One such role for CO is in ion channel regulation. Here, we examine the interaction of CO with KATP channels. We find that CO activates KATP channels and that heme binding to a CXXHX16H motif on the SUR2A receptor is required for the CO-dependent increase in channel activity. Spectroscopic and kinetic data were used to quantify the interaction of CO with the ferrous heme-SUR2A complex. The results are significant because they directly connect CO-dependent regulation to a heme-binding event on the channel. We use this information to present molecular-level insight into the dynamic processes that control the interactions of CO with a heme-regulated channel protein, and we present a structural framework for understanding the complex interplay between heme and CO in ion channel regulation.