bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting and Description for Congenital Middle Ear Malformations to Facilitate Surgical Management
Authors: Yang Feng , Liu Yang 
Published: August 2018

Introduction: The aim of this work was to report and describe the different types of congenital middle ear malformations in order to guide surgical treatment approaches and improve outcomes for affected patients. Methods: The authors reviewed patients with congenital middle ear malformations who received surgical treatment between September 2010 and March 2017. Patient characteristics, middle ear deformities, and surgical procedures were documented. Results: In this retrospective study, 35 patients were reviewed. A description of middle ear malformation was proposed that considers ear embryogenesis and focuses on stapes deformity, with the main purpose of facilitating surgical approach selection to reconstruct the ossicular chain. Patients were classified into 3 categories: type I (19 cases), mobile stapes footplate, which included type Ia with normal stapes suprastructure and type Ib with abnormal stapes suprastructure; type II (4 cases), fixed stapes footplate, which included type IIa with normal ossicular chain and type IIb with abnormal ossicular chain; and type III (12 cases), oval window bony atresia or aplasia, with or without round window atresia. Types II and III could have concomitant aberrant facial nerve. Different surgical approaches are described. Conclusions: The authors describe the different types of congenital middle ear malformations. This category description considers ear embryogenesis and is focused on stapes deformity. It may provide better understanding of disease development and guide modern hearing reconstructive surgery.
Psychotherapeutic interventions for chronic pain: Evidence, rationale, and advantages
Authors: Majeed Muhammad Hassan , Ali Ali Ahsan , Sudak Donna M 
Published: August 2018

Background Long-term use of opioids to treat chronic pain incurs serious risks for the individual—including misuse, abuse, addiction, overdose and death—as well as creating economic, social, and cultural impacts on society as a whole. Chronic pain and substance use disorders are often co-morbid with other medical problems and at the present time, primary care clinicians serve most of this population. Primary care clinicians would benefit from having alternatives to opioids to employ in treating such patients. Method We electronically searched different medical databases for studies evaluating the effect of nonpharmacological treatments for chronic pain. We describe alternative approaches for the treatment of chronic pain and cite studies that provide substantial evidence in favor of the use of these treatments. Results Cognitive behavioral therapy, acceptance and commitment therapy, and mindfulness-based programs have well-documented effectiveness for the treatment of chronic nonmalignant pain. Integration of such behavioral health therapies into primary care settings may optimize health resources and improve treatment outcomes. Conclusion Evidence-based psychotherapy for chronic pain has established efficacy and safety and improves quality of life and physical and emotional functioning. Such interventions may be used as an alternative or adjunct to pharmacological management. Chronic opioid use should be reserved for individuals undergoing active cancer treatment, palliative care, or end-of-life care.
Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding
Authors: Deen Marie , Hougaard Anders , Hansen Hanne D , Svarer Claus , Eiberg Hans , Lehel Szabolcs , Knudsen Gitte M , Ashina Messoud 
Published: August 2018

Introduction Serotonin (5-HT) plays a role in migraine pathophysiology, but whether brain 5-HT is involved in the conversion from episodic to chronic migraine is unknown. Here, we investigated brain 5-HT levels, as indexed by 5-HT4 receptor binding, in chronic migraine patients and evaluated whether these were associated with migraine frequency. Methods Sixteen chronic migraine patients underwent a dynamic PET scan after injection of [11C]SB207145, a specific 5-HT4 receptor radioligand. Data from 15 episodic migraine patients and 16 controls were included for comparison. Quantification of 5-HT4 receptor binding was used as a proxy for brain 5-HT levels, since 5-HT4 receptor binding is inversely related to brain 5-HT levels. Results Chronic migraine patients had 9.1% (95% CI: [−17%; −1.0%]) lower 5-HT4 receptor binding compared to controls ( p = 0.039). There was no difference in 5-HT4 receptor binding between chronic and episodic migraine patients ( p = 0.48) and no association between number of monthly migraine days and 5-HT4 receptor binding (slope estimate 0.003, 95% CI: [−0.004; 0.715], p = 0.39). Conclusion The finding of low 5-HT4 receptor binding suggests that cerebral levels of 5-HT are elevated in chronic migraine patients. This is in line with observations made in patients with episodic migraine. Elevated brain 5-HT levels may thus be an inherent trait of the migraine brain rather than a risk factor for conversion from episodic to chronic migraine.
Structural Violence and Migrant Deaths in Southern Arizona: Data from the Pima County Office of the Medical Examiner, 1990–2013
Authors: Martínez Daniel E. , Reineke Robin C. , Rubio-Goldsmith Raquel , Parks Bruce O. 
Published: August 2018

This article analyzes numeric trends and demographic characteristics of undocumented border crossers (UBCs) who have perished in southern Arizona between 1990 and 2013 in the area covered by the Pima County Office of the Medical Examiner (PCOME) in Tucson, Arizona. Of 2,413 UBC decedents investigated during this period, 95 percent died after 1999 and 65 percent after 2005. The rate of UBC deaths in the Tucson Border Patrol Sector has been consistently high, with an average of nearly 163 deaths investigated per year between 1999 and 2013. The increase in border enforcement during the mid-to-late 1990s, which led to a shifting of unauthorized migration flows into more desolate areas, coincided with an increase in migrant remains investigated by the PCOME. Despite a decrease in the number of unauthorized crossers traversing the area as measured by the number of Border Patrol apprehensions in the Tucson Sector, the number of remains examined for every 100,000 apprehensions nearly doubled between 2009 and 2011. These findings suggest that migrants are being forced to travel for longer periods of time through remote areas in an attempt to avoid detection by US authorities, thus increasing the probability of death. The typical UBC decedent can be described as a male near the age of 30 from central or southern Mexico who perished in a remote area of southern Arizona after attempting to cross into the United States. Nevertheless, the share of non-Mexican UBCs in the region has increased notably over time. The findings show other important differences in UBC decedent characteristics across time periods, which speak to the dynamic nature of unauthorized migration as a social process. The authors contend that these deaths and demographic changes are the result of structural and political transformations over the past two decades. They argue that the tragic, yet mostly preventable, migrant deaths in southern Arizona constitute a form of structural violence.
Mass Deportations Would Impoverish US Families and Create Immense Social Costs
Authors: Warren Robert , Kerwin Donald 
Published: August 2018

Executive Summary1 This paper provides a statistical portrait of the US undocumented population, with an emphasis on the social and economic condition of mixed-status households - that is, households that contain a US citizen and an undocumented resident. It is based primarily on data compiled by the Center for Migration Studies (CMS). Major findings include the following: • There were 3.3 million mixed-status households in the United States in 2014. • 6.6 million US-born citizens share 3 million households with undocumented residents (mostly their parents). Of these US-born citizens, 5.7 million are children (under age 18). • 2.9 million undocumented residents were 14 years old or younger when they were brought to the United States. • Three-quarters of a million undocumented residents are self-employed, having created their own jobs and in the process, creating jobs for many others. • A total of 1.3 million, or 13 percent of the undocumented over age 18, have college degrees. • Of those with college degrees, two-thirds, or 855,000, have degrees in four fields: engineering, business, communications, and social sciences. • Six million undocumented residents, or 55 percent of the total, speak English well, very well, or only English. • The unemployment rate for the undocumented was 6.6 percent, the same as the national rate in January 2014.2 • Seventy-three percent had incomes at or above the poverty level. • Sixty-two percent have lived in the United States for 10 years or more. • Their median household income was $41,000, about $12,700 lower than the national figure of $53,700 in 2014 (US Census Bureau 2015). Based on this profile, a massive deportation program can be expected to have the following major consequences: • Removing undocumented residents from mixed-status households would reduce median household income from $41,300 to $22,000, a drop of $19,300, or 47 percent, which would plunge millions of US families into poverty. • If just one-third of the US-born children of undocumented residents remained in the United States following a mass deportation program, which is a very low estimate, the cost of raising those children through their minority would total $118 billion. • The nation's housing market would be jeopardized because a high percentage of the 1.2 million mortgages held by households with undocumented immigrants would be in peril. • Gross domestic product (GDP) would be reduced by 1.4 percent in the first year, and cumulative GDP would be reduced by $4.7 trillion over 10 years. CMS derived its population estimates for 2014 using a series of statistical procedures that involved the analysis of data collected by the US Census Bureau's American Community Survey (ACS). The privacy of all respondents in the survey is legally mandated, and, for the reasons listed in the Appendix, the identity of undocumented residents cannot be derived from the data. A detailed description of the methodology used to develop the estimates is available at the CMS website.3
US Immigration Policy and the Case for Family Unity
Authors: Gubernskaya Zoya , Dreby Joanna 
Published: August 2018

As the Trump administration contemplates immigration reform, it is important to better understand what works and what does not in the current system. This paper reviews and critically evaluates the principle of family unity, a hallmark of US immigration policy over the past 50 years and the most important mechanism for immigration to the United States. Since 1965, the United States has been admitting a relatively high proportion of family-based migrants and allowing for the immigration of a broader range of family members. However, restrictive annual quotas have resulted in a long line of prospective immigrants waiting outside of the United States or within the United States, but without status. Further policy changes have led to an increasing number of undocumented migrants and mixed-status families in the United States. Several policies and practices contribute to prolonged periods of family separation by restricting travel and effectively locking in a large number of people either inside or outside of the United States. On top of that, increasingly aggressive enforcement practices undermine family unity of a large number of undocumented and mixed-status families. Deportations — and even a fear of deportation —cause severe psychological distress and often leave US-born children of undocumented parents without economic and social support. A recent comprehensive report concluded that immigration has overall positive impact on the US economy, suggesting that a predominantly family-based migration system carries net economic benefits. Immigrants rely on family networks for employment, housing, transportation, informal financial services, schooling, childcare, and old age care. In the US context where there is nearly no federal support for immigrants' integration and limited welfare policies, family unity is critical for promoting immigrant integration, social and economic well-being, and intergenerational mobility. Given the benefits of family unity in the US immigrant context and the significant negative consequences of family separation, the United States would do well to make a number of changes to current policy and practice that reaffirm its commitment to family unity. Reducing wait times for family reunification with spouses and children of lawful permanent residents, allowing prospective family-based migrants to visit their relatives in the United States while their applications are being processed, and providing relief from deportation and a path to legalization to parents and spouses of US citizens should be prioritized. The cost to implement these measures would likely be minor compared to current and projected spending on immigration enforcement and it would be more than offset by the improved health and well-being of American families.
Prevalence of MTD among Patients with Functional Dysphagia
Authors: Hamdan Abdul‐Latif , Ziade Georges , Khalifee Elie , Al Souky Nader , Jaffal Hussein , El Natout Tamer 
Published: August 2018

ObjectiveTo assess the prevalence of laryngeal muscle tension patterns among patients with functional dysphagia.Study DesignRetrospective study.SettingThe study took place at a university medical center.Material and MethodsThe medical charts and laryngeal video recordings were reviewed for all patients who presented with dysphagia and who were referred for barium swallow between 2012 and 2017. A total of 170 cases were identified. Only those with normal findings on barium swallow and the absence of vocal fold pathology (exudative lesions, masses or tumors, paresis, and paralysis), referred to asfunctional dysphagia, were included in this study. Information retrieved included swallowing and phonatory symptoms in addition to patterns of laryngeal muscle tension.ResultsThe mean ± SD age of the total group was 41.90±15.10 years with a male:female ratio of 4:1. Seventy‐five percent had evidence of at least 1 type of laryngeal muscle tension pattern. The most common pattern was type III, characterized by supraglottic anteroposterior compression (13 of 20), followed by type II, characterized by medial compression of the false vocal folds (5 of 20); only 1 patient had muscle tension pattern type IV, characterized as sphincter‐like closure of supraglottic structures. The most common laryngopharyngeal symptom was throat discomfort when swallowing (35%), followed by throat clearing and choking/coughing when eating and drinking (25%).ConclusionThe high prevalence of laryngeal muscle tension pattern among patients with functional dysphagia supports the notion that laryngeal tension may be one of the underlying causes of dysphagia.
The replicative histone chaperone CAF1 is essential for the maintenance of identity and genome integrity in adult stem cells
Authors: Clémot Marie , Molla-Herman Anahi , Mathieu Juliette , Huynh Jean-René , Dostatni Nathalie 
Published: August 2018

ABSTRACT
Chromatin packaging and modifications are important to define the identity of stem cells. How chromatin properties are retained over multiple cycles of stem cell replication, while generating differentiating progeny at the same time, remains a challenging question. The chromatin assembly factor CAF1 is a conserved histone chaperone, which assembles histones H3 and H4 onto newly synthesized DNA during replication and repair. Here, we have investigated the role of CAF1 in the maintenance of germline stem cells (GSCs) in Drosophila ovaries. We depleted P180, the large subunit of CAF1, in germ cells and found that it was required in GSCs to maintain their identity. In the absence of P180, GSCs still harbor stem cell properties but concomitantly express markers of differentiation. In addition, P180-depleted germ cells exhibit elevated levels of DNA damage and de-repression of the transposable I element. These DNA damages activate p53- and Chk2-dependent checkpoints pathways, leading to cell death and female sterility. Altogether, our work demonstrates that chromatin dynamics mediated by CAF1 play an important role in both the regulation of stem cell identity and genome integrity.
Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression
Authors: Hasenpusch-Theil Kerstin , West Stephen , Kelman Alexandra , Kozic Zrinko , Horrocks Sophie , McMahon Andrew P. , Price David J. , Mason John O. , Theil Thomas 
Published: August 2018

ABSTRACT
The cerebral cortex contains an enormous number of neurons, allowing it to perform highly complex neural tasks. Understanding how these neurons develop at the correct time and place and in accurate numbers constitutes a major challenge. Here, we demonstrate a novel role for Gli3, a key regulator of cortical development, in cortical neurogenesis. We show that the onset of neuron formation is delayed in Gli3 conditional mouse mutants. Gene expression profiling and cell cycle measurements indicate that shortening of the G1 and S phases in radial glial cells precedes this delay. Reduced G1 length correlates with an upregulation of the cyclin-dependent kinase gene Cdk6, which is directly regulated by Gli3. Moreover, pharmacological interference with Cdk6 function rescues the delayed neurogenesis in Gli3 mutant embryos. Overall, our data indicate that Gli3 controls the onset of cortical neurogenesis by determining the levels of Cdk6 expression, thereby regulating neuronal output and cortical size.
Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice
Authors: Jørgensen Mette C. , de Lichtenberg Kristian H. , Collin Caitlin A. , Klinck Rasmus , Ekberg Jeppe H. , Engelstoft Maja S. , Lickert Heiko , Serup Palle 
Published: August 2018

ABSTRACT
Mutations in Hes1, a target gene of the Notch signalling pathway, lead to ectopic pancreas by a poorly described mechanism. Here, we use genetic inactivation of Hes1 combined with lineage tracing and live imaging to reveal an endodermal requirement for Hes1, and show that ectopic pancreas tissue is derived from the dorsal pancreas primordium. RNA-seq analysis of sorted E10.5 Hes1+/+ and Hes1−/− Pdx1-GFP+ cells suggested that upregulation of endocrine lineage genes in Hes1−/− embryos was the major defect and, accordingly, early pancreas morphogenesis was normalized, and the ectopic pancreas phenotype suppressed, in Hes1−/−Neurog3−/− embryos. In Mib1 mutants, we found a near total depletion of dorsal progenitors, which was replaced by an anterior Gcg+ extension. Together, our results demonstrate that aberrant morphogenesis is the cause of ectopic pancreas and that a part of the endocrine differentiation program is mechanistically involved in the dysgenesis. Our results suggest that the ratio of endocrine lineage to progenitor cells is important for morphogenesis and that a strong endocrinogenic phenotype without complete progenitor depletion, as seen in Hes1 mutants, provokes an extreme dysgenesis that causes ectopic pancreas.
Reactive oxygen species in plant development
Authors: Mhamdi Amna , Van Breusegem Frank 
Published: August 2018

ABSTRACT
Reactive oxygen species (ROS) are produced by metabolic pathways in almost all cells. As signaling components, ROS are best known for their roles in abiotic and biotic stress-related events. However, recent studies have revealed that they are also involved in numerous processes throughout the plant life cycle, from seed development and germination, through to root, shoot and flower development. Here, we provide an overview of ROS production and signaling in the context of plant growth and development, highlighting the key functions of ROS and their interactions with plant phytohormonal networks.
RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling
Authors: Park Eun Chan , Rongo Christopher 
Published: August 2018

ABSTRACT
Axons must correctly reach their targets for proper nervous system function, although we do not fully understand the underlying mechanism, particularly for the first ‘pioneer’ axons. In C. elegans, AVG is the first neuron to extend an axon along the ventral midline, and this pioneer axon facilitates the proper extension and guidance of follower axons that comprise the ventral nerve cord. Here, we show that the ubiquitin ligase RPM-1 prevents the overgrowth of the AVG axon by repressing the activity of the DLK-1/p38 MAPK pathway. Unlike in damaged neurons, where this pathway activates CEBP-1, we find that RPM-1 and the DLK-1 pathway instead regulate the response to extracellular Wnt cues in developing AVG axons. The Wnt LIN-44 promotes the posterior growth of the AVG axon. In the absence of RPM-1 activity, AVG becomes responsive to a different Wnt, EGL-20, through a mechanism that appears to be independent of canonical Fz-type receptors. Our results suggest that RPM-1 and the DLK-1 pathway regulate axon guidance and growth by preventing Wnt signaling crosstalk.
Por que o descompasso?
Authors: Lacombe Beatriz Maria Braga , Cepellos Vanessa Martines 
Published: August 2018

O setor de recursos humanos (RH) e os gestores das organizações vivem em eterna briga. De um lado, gestores acham que o RH é inútil. Do outro, o RH acredita ser visto de forma estereotipada. Para solucionar a disputa, ambas as partes terão de se esforçar.
Vein to vein: exploring blood supply chains in Canada
Authors: Maeng Jung-Joo , Sabharwal Kayla , Ülkü M. Ali 
Published: August 2018

There is not yet any substitute for human blood which remains a scarce resource in many countries. Effective and efficient management of blood supply chains (BSCs) is utmost important in the healthcare industry. This paper gives an overview of the BSC and how blood products are used at hospitals to provide life-saving services to patients. Factoring in the blood types and their receipt compatibility, a simple inventory model is proposed. Using secondary data, the model is illustrated by way of a small case study in Nova Scotia, Canada. We highlight that due to both demand and supply uncertainties, and due to its perishable nature, inventorying blood products is not straightforward and brings with it many logistical and management challenges in the BSC.
Market Reaction to Mandatory Nonfinancial Disclosure
Authors: Grewal Jody , Riedl Edward J. , Serafeim George 
Published: August 2018

We examine the equity market reaction to events associated with the passage of a directive in the European Union (EU) mandating increased nonfinancial disclosure. These disclosures relate to firms’ environmental, social, and governance (ESG) performance, and would be applicable to firms listed on EU exchanges or with significant operations in the EU. We predict and find (i) an average negative market reaction of –0.79% across all firms, (ii) a less negative market reaction for firms having higher predirective nonfinancial performance, and (iii) a less negative reaction for firms having higher predirective nonfinancial disclosure levels. In addition, results are accentuated for firms having the most material ESG issues, as well as investors anticipating proprietary and political costs as a result of the mandated disclosures. Finally, we find that the negative market reaction is concentrated in firms with weak preregulation ESG performance and disclosure, which exhibit an average return of –1.54%; in contrast, firms with strong preregulation disclosure and performance exhibit an average positive return of 0.52%. Overall, the results are consistent with the equity market perceiving net costs (benefits) for firms with weak (strong) nonfinancial performance and disclosure around key events surrounding the mandatory disclosure regulation of nonfinancial information. This paper was accepted by Shiva Rajgopal, accounting.