bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of social media for communicating about critical care topics: A Norwegian cross‐sectional survey
Authors: Petosic Antonija , Sunde Kjetil , Beeckman Dimitri , Flaatten Hans K. , Wøien Hilde 
Published: July 2019

BackgroundSocial media (SoMe) might be an alternative platform for communicating critical care topics to implement evidence‐based practice in the intensive care unit (ICU). This survey aims to describe ICU nurses’ and physicians’ use of SoMe in general, and their perception of using closed Facebook‐groups for receiving content on critical care topics.MethodsA cross‐sectional, web‐based, anonymous survey was distributed to ICU physicians and nurses in four ICUs in autumn 2017 via an email‐campaign. Descriptive statistics with rates, percentages and median numeric rating scale (NRS) scores, interquartile ranges are presented.ResultsThe response‐rate was 64% (253/ 394) including 210 nurses and 43 physicians. Overall, 93% had a SoMe‐profile, and 77% had a profile on more than one network site. Facebook was the most used social network site, with 87% having a profile. Totally, 68% were daily users, but more nurses used Facebook daily vs physicians (81% vs 60%, respectively, P = 0.006). Nurses were also more positive toward being members of closed Facebook‐groups aimed to exchange content on critical care topics (median NRS 9 (6‐10) vs 6 (3‐9), respectively, P = 0.014).ConclusionThe majority of ICU nurses and physicians were active SoMe users, mainly for personal purposes, and Facebook was the most popular SoMe. Nurses used Facebook daily more frequent and were more positive toward content on critical care topics on Facebook than physicians. These findings might be relevant to customize future communication about critical care topics via SoMe.
Salpingectomy at the time of hysterectomy for benign gynaecological disease: A comparison of surgical approaches
Authors: Obermair Helena M. , Borg Emma J. 
Published: July 2019

Given that a significant percentage of high‐grade serous cancers develop in the fallopian tube, it has been suggested that salpingectomy may prevent some of these malignancies. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists guidelines recommend prophylactic salpingectomy to be discussed with or offered to patients undergoing hysterectomy for benign indications. This study compares rates of salpingectomy at the time of hysterectomy for benign indications across different surgical approaches among Australian and New Zealand gynaecologists. Data were collected via SurgicalPerformance, a web‐based surgical outcomes review and feedback software used by independent gynaecologic surgeons. Of 11 477 hysterectomy records available, 6608 were eligible for analysis. Rates of salpingectomy at vaginal hysterectomy (13%) were significantly lower (P < 0.001) compared to open abdominal (65%), laparoscopic (70%), laparoscopic‐assisted vaginal (78%), or robotic hysterectomies (73%) and also lower than in hysterectomies converted to an open abdominal approach (73%).
Accurate identification of the pastry contained in a ceramic pot excavated from Jurou Li's grave from the Jin dynasty (1115–1234 ce) in Xi'an, Shaanxi, China
Authors: Zhu Z. , Yu C. , Luo W. , Miao Y. , Lu Z. , Liu L. , Yang J. 
Published: July 2019

In order to identify accurately the circular object contained in the ceramic pot excavated from Jurou Li's grave of the Jin dynasty (1115–1234 ce) in Xi'an, Shaanxi, China, mass spectrometry was applied to determine the amino acid sequences of the residual proteins extracted from the sample, after preliminary starch grain analysis. The sequences were searched against a standard protein sequence database. The proteins extracted were identified as originating from domesticated barley (Hordeum vulgare), soybean (Glycine max), and fermentative microorganisms (Kluyveromyces lactis, Lipomyces starkeyi, Wickerhamomyces ciferrii, Nadsonia fulvescens and Zygosaccharomyces rouxii). These findings indicate that the extremely degraded object in the ceramic pot was made from barley by fermentation with the addition of soy sauce, providing direct evidence of culinary culture in the Jin dynasty.
Evaluation of parameters obtained from two systems of gait analysis
Authors: Assaf ND , Rahal SC , Mesquita LR , Kano WT , Abibe RB 
Published: July 2019

BackgroundThe technical difficulties in utilising the force platform have stimulated the use and development of other gait systems. Therefore, this study aimed to compare the values of gait parameters obtained from a pressure‐sensitive walkway and from a treadmill in healthy dogs during walking.MethodsTwelve healthy, privately owned, Labrador retriever dogs were used. During each trial, each dog was led across the pressure‐sensitive walkway utilising a loose leash to the right of the handler. The velocity was restricted to the range of 0.9 to 1.1 m/s and the acceleration between −0.15 and 0.15 m/s2. For the treadmill, each dog also walked with leash loose on the treadmill. The treadmill speed was maintained at 0.9m/s. The temporospatial variables, and percentage of body weight distribution/percentage of pressure were evaluated between the two gait systems.ResultsFor both forelimbs and hind limbs, significant differences were found between stance percentage, which was higher on treadmill, and swing percentage and stride length/stance distance, which were higher on the pressure‐sensitive walkway. The duty factor value was 0.57 for the pressure‐sensitive walkway and 0.60 for treadmill.Clinical relevanceEach gait system has limitations, but also advantages that must be considered depending upon the variable and animal to be evaluated. The gait parameters obtained from the Tekscan pressure‐sensitive walkway and Gait4Dog treadmill revealed differences in the temporospatial parameters between systems, but similarity in body‐weight distribution/pressure percentage.
Image‐Based Tree Variations
Authors: Argudo Oscar , Andújar Carlos , Chica Antoni 
Published: July 2019

AbstractThe automatic generation of realistic vegetation closely reproducing the appearance of specific plant species is still a challenging topic in computer graphics. In this paper, we present a new approach to generate new tree models from a small collection of frontal RGBA images of trees. The new models are represented either as single billboards (suitable for still image generation in areas such as architecture rendering) or as billboard clouds (providing parallax effects in interactive applications). Key ingredients of our method include the synthesis of new contours through convex combinations of exemplar countours, the automatic segmentation into crown/trunk classes and the transfer of RGBA colour from the exemplar images to the synthetic target. We also describe a fully automatic approach to convert a single tree image into a billboard cloud by extracting superpixels and distributing them inside a silhouette‐defined 3D volume. Our algorithm allows for the automatic generation of an arbitrary number of tree variations from minimal input, and thus provides a fast solution to add vegetation variety in outdoor scenes.
Variable loss of CD30 expression by immunohistochemistry in recurrent cutaneous CD30+ lymphoid neoplasms treated with brentuximab vedotin
Authors: Goyal Amrita , Patel Sanjay , Goyal Kavita , Morgan Elizabeth A. , Foreman Ruth K. 
Published: July 2019

AbstractAimsBrentuximab vedotin is a monoclonal anti‐CD30 antibody‐drug conjugate that has been used to treat a variety of CD30+ neoplasms. The phenomenon of antigen loss has been observed in patients treated with the anti‐CD20 antibody rituximab. This study seeks to assess for antigen loss in the setting of recurrent CD30+ neoplasms treated with brentuximab vedotin.MethodsWe report nine cases of persistent/recurrent cutaneous CD30+ lymphoid neoplasms that demonstrated variable CD30 expression after treatment with brentuximab vedotin. Cases include MF (n = 6), cutaneous T‐cell lymphoma, not otherwise specified (n = 1), and anaplastic large cell lymphoma (ALCL), both primary (n = 1) and systemic (n = 1).ResultsImmunohistochemical staining revealed decreased CD30 expression following brentuximab vedotin therapy in seven of nine cases. In these seven cases, the pre‐treatment percent of tumor cells staining for CD30 ranged from 10% to 100% (mean 50.0%, SD 27.8%), compared to 5% to 50% (mean 14.5%, SD 14.8%, P = 0.003) at recurrence.ConclusionsThis case series highlights the finding that CD30 positivity can be variable in recurrences after treatment with anti‐CD30 antibodies. This serves to raise awareness of the phenomenon of antigen loss after treatment with brentuximab vedotin and underscores the utility of performing multiple biopsies and/or employing molecular diagnostic techniques in patients with recurrent/persistent disease.
Impacts of 21st‐century climate change on montane habitat in the Madrean Sky Island Archipelago
Authors: Yanahan Alan D. , Moore Wendy 
Published: July 2019

AbstractAimThe Madrean Sky Island Archipelago is a North American biodiversity hotspot composed of ~60 isolated mountains that span the Cordilleran Gap between the Rocky Mountains and the Sierra Madre Occidental. Characterized by discrete patches of high‐elevation montane habitat, these “sky islands” serve as stepping stones across a “sea” of desert scrub/grassland. Over this coming century, the region is expected to shift towards a warmer and drier climate. We used species distribution modelling to predict how the spatial distribution of montane habitat will be affected by climate change.LocationMadrean Sky Island Archipelago, south‐west United States and north‐west Mexico (latitude, 29–34°N; longitude, 107–112°W).MethodsTo approximate the current distribution of montane habitat, we built species distribution models for five high‐elevation species (Ceanothus fendleri, Pinus strobiformis, Quercus gambelii, Sciurus aberti, and Synuchus dubius). The resulting models were projected under multiple climate change scenarios—four greenhouse gas concentration trajectories (RCP 2.6, 4.5, 6.0, and 8.5) for each of three climate models (CCSM4, MPI‐ESM‐LR, and NorESM1‐M)—to generate predicted distributions for the years 2050 and 2070. We performed chi‐squared tests to detect any future changes to total montane habitat area, and Conover–Iman tests to evaluate isolation among the discrete montane habitat patches.ResultsWhile the climate models differ with respect to their predictions as to how severe the effects of future climate change will be, they all agree that by as early as year 2050, there will be significant montane habitat loss and increased montane habitat patch isolation across the Madrean Archipelago region under a worst‐case climate change scenario (RCP 8.5).Main conclusionsOur results suggest that under 21st‐century climate change, the Madrean Sky Islands will become increasingly isolated due to montane habitat loss. This may affect their ability to serve as stepping stones and have negative implications for the region's biodiversity.
Surviving cardiac arrest from mitral annular disjunction: A case report
Authors: Bennett Sadie , Phan Thanh , Patwala Ashish , Thamman Ritu , Kwok Chun Shing 
Published: July 2019

AbstractA 38‐year‐old man with no previous medical history presented to hospital after having an out‐of‐hospital cardiac arrest. He was found to have a ventricular fibrillation and was successfully resuscitated after receiving cardiopulmonary resuscitation and three shocks. Extensive investigations were performed which included an electrocardiogram that showed no significant abnormality, coronary angiogram which showed unobstructed arteries, and a flecainide challenge test which was negative for Brugada syndrome. A resting echocardiogram showed a myxomatous mitral valve with mild bi‐leaflet bowing, trivial mitral regurgitation, normal left ventricular systolic function, and no other structural abnormalities. A cardiac magnetic resonance imaging showed no significant late gadolinium enhancement to suggest infarct or myocardial scarring. He was subsequently diagnosed with idiopathic ventricular fibrillation and treated with a subcutaneous internal cardioverter‐defibrillator for secondary prevention. A follow‐up echocardiogram was performed which revealed the presence of mitral annular disjunction which has been recently shown to be associated with significant life‐threatening arrhythmias and sudden cardiac death. This case highlights the importance of improving awareness of mitral annular disjunction which is not often considered as a cause for adverse patient outcomes.
Massive obliterative right heart thrombus presenting with near‐syncope
Authors: Torres Christian , Doukky Rami 
Published: July 2019

AbstractIntracardiac thrombi are commonly encountered as a complication of a recent myocardial infarction, heart failure, atrial fibrillation, or intracardiac devices. The prevalence of atrial thrombi in the absence of these risk factors is not well‐described, but seems to be low. We present a case of a 51‐year‐old man with a massive mobile thrombus in the right heart extending through the tricuspid valve, diagnosed on echocardiography after presenting with a presyncopal episode.
Multiattribute decision making based on power operators for linguistic intuitionistic fuzzy set using set pair analysis
Authors: Garg Harish , Kumar Kamal 
Published: July 2019

AbstractThe aim of the presented paper is to give a multiattribute decision making (MADM) method under the linguistic intuitionistic fuzzy (LIF) environment using the set pair analysis (SPA) theory. LIF set can express the qualitative information in terms of linguistic variables, whereas the connection number (CN) based on the “identity,” “discrepancy,” and “contrary” degrees of the SPA theory handles the uncertainties and certainties systems. On the basis of these features, we develop some series of linguistic CN (LCN) power weighted and ordered weighted geometric aggregation operator to aggregate the different LCNs. Several properties of the operators are also studied. Afterward, we present a novel MADM method to solve decision‐making problems under LIF set environment and illustrate with several examples to validate it. A comparative analysis is also presented to show the results.
Controlled randomized trial of walking exercise with positive education on cardiovascular fitness and happiness in retired older adults
Authors: Lee Tony Szu‐Hsien , Hung Chia‐Chun , Lin Chao‐Kuang , Chiang Hui‐Hsun 
Published: July 2019

AimRegular walking exercise (RWE) is associated with increased cardiovascular fitness and might elevate subjective psychological well‐being. Positive education links positive psychology concepts with self‐efficacy through the curriculum, which helps foster well‐being. This study examines if regular walking exercise with positive education has better effects on cardiovascular fitness and happiness than RWE alone in retired older adults.MethodsThree arms of experimental design were used: pedometer walking exercise training (PWET); positive education and pedometer walking exercise training (PEPWET); and pedometer walking exercise (PWE). Trained walking exercise was provided to the PWET and PEPWET groups by a walking exercise coach three times per week, for 45 min per session for 12 weeks. Positive education was designed and led by a licensed PhD psychologist every other week. Of 150 participants, 60, 60 and 30 were randomly assigned to PWET, PEPWET and PWE, respectively. Demographic information, Chinese Happiness Inventory, RWE, and 6‐min walking distance were assessed before and after the intervention.ResultsThe percentage of participants who practiced RWE after 12 weeks was significantly higher in the PEPWET group (96.7%), followed by the PWET (75%) and PWE groups (40%). Cardiovascular fitness in the PWET and PEPWET groups was significantly better than in the PWE group. Chinese Happiness Inventory scores in the PWET and PEPWET groups were significantly higher than in the PWE group, and the PEPWET group also showed significantly higher Chinese Happiness Inventory scores than the PWET group.ConclusionsIn addition to RWE, the study findings show that positive education can be beneficial to promote older adults’ RWE, cardiovascular fitness and happiness. Geriatr Gerontol Int 2019; 19: 879–884.
A questionnaire‐based study of attitudes to spirituality in mental health practitioners and the relevance of the concept of spiritually competent care
Authors: Rogers Melanie , Wattis John , Stephenson John , Khan Wajid , Curran Stephen 
Published: July 2019

AbstractIn the light of the increasing recognition of the relevance of spirituality in person‐centred, holistic care, this study examines the attitudes of a convenience sample of mental health practitioners, including nurses, to the concepts of spirituality in general and in clinical practice. A series of 5‐point Likert‐style items assessed two key domains of spirituality in everyday life (SEDL) and spirituality in practice (SIP). The questionnaire was derived from one previously used with healthcare educators (including nurses). Each item was scored from 1 point (strongly disagree) to 5 points (strongly agree). Additional information about how far practitioners believed spirituality had been integrated in their education and how much they believed that spirituality related to religion was also ascertained. Three further items, not part of the main questionnaire, dealt with respondents’ views of spirituality competent practice, in the light of a description provided as part of the questionnaire. Data were collected from 104 respondents. Standard statistical procedures, including reliability analyses, were applied to the data. Respondents who viewed spirituality to be distinct from religion, or a place of worship, were likely to place a higher value on spirituality in everyday life, while respondents who experienced the integration of spirituality within their preregistration training and/or clinical education were likely to place a higher value on the place of spirituality in practice. The possible reasons for these associations are discussed in the light of the importance of spiritual care as a part of person‐centred, holistic practice.
MicroRNA‐351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus
Authors: Chen Shu‐Hong , Liu Xiao‐Nan , Peng Yan 
Published: July 2019

AbstractGestational diabetes mellitus (GDM) is known as different degree glucose intolerance that is initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for treatment of GDM. Herein, we suggested that miR‐351 could be an inhibitor in the progression of GDM via the phosphoinositide 3‐kinase/protein kinase B (PI3K/AKT) pathway. Microarray analysis was used to identify differentially expressed genes and predict miRs regulating flotillin 2 (FLOT2). Target relationship between miR‐351 and FLOT2 was verified. Gestational diabetes mellitus mice were treated with a series of mimic, inhibitor and small interfering RNA to explore the effect of miR‐351 on insulin resistance (IR), cell apoptosis in pancreatic tissues and liver gluconeogenesis through evaluating GDM‐related biochemical indexes, as well as expression of miR‐351, FLOT2, PI3K/AKT pathway‐, IR‐ and liver gluconeogenesis‐related genes. MiR‐351 and FLOT2 were reported to be involved in GDM. FLOT2 was the target gene of miR‐351. Gestational diabetes mellitus mice exhibited IR and liver gluconeogenesis, up‐regulated FLOT2, activated PI3K/AKT pathway and down‐regulated miR‐351 in liver tissues. Additionally, miR‐351 overexpression and FLOT2 silencing decreased the levels of FLOT2, phosphoenolpyruvate carboxykinase, glucose‐6‐phosphatase, fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glyeosylated haemoglobin and homeostasis model of assessment for IR index (HOMA‐IR), extent of PI3K and AKT phosphorylation, yet increased the levels of HOMA for islet β‐cell function, HOMA for insulin sensitivity index and glucose transporter 2 expression, indicating reduced cell apoptosis in pancreatic tissues and alleviated IR and liver gluconeogenesis. Our results reveal that up‐regulation of miR‐351 protects against IR and liver gluconeogenesis by repressing the PI3K/AKT pathway through regulating FLOT2 in GDM mice, which identifies miR‐351 as a potential therapeutic target for the clinical management of GDM.
Response to IL‐17A inhibitors secukinumab and ixekizumab cannot be explained by genetic variation in the protein‐coding and untranslated regions of the IL‐17A gene: results from a multicentre study of four European psoriasis cohorts
Authors: van Vugt L.J. , van den Reek J.M.P.A. , Meulewaeter E. , Hakobjan M. , Heddes N. , Traks T. , Kingo K. , Galluzzo M. , Talamonti M. , Lambert J. , Coenen M.J.H. , de Jong E.M.G.J. 
Published: July 2019

AbstractBackgroundGenetic predictors for treatment response could optimize allocation of biological treatment in patients with psoriasis. There is minimal knowledge about pharmacogenetics of anti‐IL‐17 agents.ObjectivesTo assess whether genetic variants in the protein‐coding region or untranslated regions of the IL‐17A gene are associated with response to IL‐17A inhibitors in patients with psoriasis.MethodsThis was a multicenter European cohort study investigating pharmacogenetics of IL‐17A inhibitors in patients with psoriasis. Patients with plaque psoriasis treated with secukinumab or ixekizumab in daily practice were included. For all participants, the protein‐coding region and untranslated regions of the IL‐17A gene were analysed using Sanger sequencing. Identified genetic variants were tested for association with response to secukinumab/ixekizumab, measured as ∆PASI, after 12 weeks (primary outcome) and after 24 weeks (secondary outcome). Association was tested using a linear regression model with correction for baseline PASI as a fixed covariate and for biological naivety and body mass index as additional covariates.ResultsIn total, 134 patients treated with secukinumab or ixekizumab were included. Genotyping of the cohort identified genetic variants present in untranslated regions and intronic DNA, but not in the protein‐coding region of the IL‐17A gene. Five genetic variants in non‐coding DNA with a known or suspected functional effect on IL‐17A expression were selected for association analyses: rs2275913, rs8193037, rs3819025, rs7747909 and rs3748067. After 12 weeks, 62% of patients achieved PASI75 and 39% achieved PASI90. At week 24, PASI75 and PASI90 response rates were 72% and 62%, respectively. No associations were found between the five genetic variants and ∆PASI, PASI75 or PASI90 after 12 and 24 weeks of anti‐IL‐17A treatment.ConclusionsResponse to IL‐17A inhibitors secukinumab and ixekizumab cannot be explained by genetic variation in the protein‐coding and untranslated regions of the IL‐17A gene. Pharmacogenetics of IL‐17A inhibitors in the treatment of psoriasis requires further exploration.