bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermal regeneration template and vacuum sealing drainage for treatment of traumatic degloving injuries of upper extremity in a single‐stage procedure
Authors: Lv Zhenmu , Yu Lili , Wang Qiusheng , Jia Rui , Ding Wenyuan , Shen Yong 
Published: June 2019

BackgroundThis study aimed to assess the efficacy and safety of a single‐stage procedure using single‐layer Pelnac and defatted avulsed skin for the management of degloving injuries of the forearm and hand.MethodsThis is a prospective study conducted from March 2013 to May 2017. A total of 15 consecutive patients with degloving injuries of the forearm and hand were treated with a single‐stage procedure using single‐layer Pelnac and defatted avulsed skin as a split‐thickness skin graft. Post‐operatively, scheduled follow‐up was conducted.ResultsThe overall ‘take’ rate of the Pelnac dermal template and the skin graft was 85–100%. No infections, haematoma or seroma were observed during hospitalization and after discharge. At the final follow‐up, patients’ subjective satisfaction with the aesthetic appearance of the grafted areas was, on average, 71.0 (SD 8.0, range 55–92). The Vancouver Scar Scale value was 2.1 (SD 1.8, range 1.0–5.5), representing a good result. The response of ‘normal or near normal’ to the sensory recovery was obtained for 13 patients and ‘slight loss’ for two patients. The average Disabilities of the Arm, Shoulder and Hand score was 21.2 (SD 13.5, range 0–53), and most patients (14/15) regained the ability to perform the daily activities without pain or restriction by tissue adhesion.ConclusionThis single‐stage procedure represents an effective technique for the management of degloving injuries of the forearm and hand and should be considered an alternative to other reconstructive procedures.
Development and validation of the Satisfaction with Treatment for Pain Questionnaire (STPQ) among patients with sickle cell disease
Authors: Elander James , Bij Deepali , Kapadi Romaana , Schofield Malcolm B. , Osias Arlene , Khalid Nosheen , Kaya Banu , Telfer Paul 
Published: June 2019

SummaryA brief measure of patient satisfaction with treatment for pain is needed to help improve the treatment of painful episodes caused by sickle cell disease (SCD), especially during and after the transition from paediatric to adult care. Focus groups of 28 adolescent and adult patients were consulted about the content, clarity and relevance of 30 potential items, resulting in an 18‐item version. This was validated by analysing questionnaire responses from 120 patients aged 12–53 years. Confirmatory factor analysis and item analysis indicated five subscales with high internal reliability: ‘Communication and Involvement’ (6 items, α = 0·87); ‘Respect and Dignity’ (3 items, α = 0·82); ‘Pain Control’ (3 items, α = 0·91); ‘Staff Attitudes and Behaviour’ (4 items, α = 0·88); and ‘Overall Satisfaction’ (2 items, α = 0·85) plus a Total Satisfaction score (18 items, α = 0·96). High negative correlations with the Picker Patient Experience Questionnaire, a measure of problem experiences, indicated good convergent validity. Lower satisfaction scores among patients aged over 18 years, those admitted via the emergency department, those treated by non‐specialist hospital staff, and those reporting more breakthrough pain indicated good concurrent validity. The questionnaire provides a convenient brief measure that can be used to inform and evaluate improvements in healthcare for adolescent and adult patients with SCD, and could potentially be adapted for other painful conditions.
Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia
Authors: Huang Ying‐Jung , Kuo Ming‐Chung , Chang Hung , Wang Po‐Nan , Wu Jin‐Hou , Huang Yen‐Min , Ma Ming‐Chun , Tang Tzung‐Chih , Kuo Ching‐Yuan , Shih Lee‐Yung 
Published: June 2019

SummaryChronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries but very rare in Asia. Peripheral blood or bone marrow mononuclear cells obtained at initial diagnosis from 194 patients with CLL were analysed to determine the ethnic difference in genetic abnormalities. Mutated IGHV was detected in 71·2% of Taiwanese CLL and IGHV3‐23 was the most frequently used gene. Stereotyped BCR was present in 18·3% with subset 8 being the most frequent. All cases with subset 8 belonged to IGHV 4‐39 and were exclusively associated with un‐mutated IGHV and poor outcome. Mutation frequencies of SF3B1 (9·7%), NOTCH1 (8·6%), BIRC3 (1·1%), ATM (16·9%) or TP53 (8·1%), and frequencies of cytogenetic abnormalities including trisomy 12 (18·6%), del(17p) (10·4%), del(13q) (43·7%) and IGH translocation (10·1%) were comparable to those reported from Western countries, except del(11q) (6·9%) which was lower in our patients. Patients with un‐mutated IGHV, subset 8, disrupted TP53, trisomy 12, and SF3B1 mutations had a worse outcome compared to patients without these mutations. In conclusion, IGHV3‐23 usage, stereotyped subset 8 and lower frequency of del(11q) show an ethnicity‐dependent association in Taiwanese CLL patients.
Two‐part implant abutments with titanium and ceramic components: Surface modification affects retention forces—An in‐vitro study
Authors: Freifrau von Maltzahn Nadine , Bernard Sebastian , Kohorst Philipp 
Published: June 2019

AbstractObjectivesTwo‐part abutments consist of titanium base and ceramic coping. Their long‐term success is largely determined by the mechanical stability. The aim of the present study was to investigate the retention forces of two‐part implant abutments. The study included zirconia and lithium disilicate ceramics copings, with different surface treatments and resin‐based luting agents.Material and MethodsThe analysis of retention forces was based on a total of 70 test specimens. Seven surface modifications and three resin‐based luting agents were employed for the bonding of components in the seven groups (n = 70). All surfaces of titanium bases—except for a control—were pretreated with aluminum oxide blasting, either alone or in combination with surface activating primers. Surfaces of ceramic copings were also treated mechanically by sandblasting, either alone or with acid etching or different primers. All specimens underwent thermal aging (104 cycles, 5°C/55°C). The retention forces between the two parts were measured with a pull‐off test. The results were analyzed by two‐way ANOVA statistics. Fracture patterns were evaluated by light and scanning electron microscopy.ResultsNo mechanical pretreatment of the titanium (group 2) base resulted in the lowest retention. The combination with Monobond plus leads to the highest pull‐off forces for both ceramic materials.ConclusionsSurface modifications and resin‐based agents influence the retention of components of two‐part abutments. Lithium disilicate ceramic copings reached comparable results of retention to the typically used zirconia copings.
The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review
Authors: Lechien Jerome R. , Muls Vinciane , Dapri Giovanni , Mouawad François , Eisendrath Pierre , Schindler Antonio , Nacci Andrea , Barillari Maria R. , Finck Camille , Saussez Sven , Akst Lee M. , Sataloff Robert T. 
Published: June 2019

AbstractObjectiveTo summarise current knowledge about the prevalence, aetiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients—those who do not respond to anti‐reflux medical treatment.MethodsA literature search was conducted following the PRISMA guidelines to identify studies that reported success of anti‐reflux medical treatment with emphasis on studies that attempted to be rigorous in defining a population of LPR patients and which subsequently explored the characteristics of non‐responder patients (ie aetiology of resistance; differential diagnoses; management and treatment). Three investigators screened publications for eligibility from PubMED, Cochrane Library and Scopus and excluded studies based on predetermined criteria. Design, diagnostic method, exclusion criteria, treatment characteristics, follow‐up and quality of outcome assessment were evaluated.ResultsOf the 139 articles screened, 45 met the inclusion criteria. The definition of non‐responder patients varied substantially from one study to another and often did not include laryngopharyngeal signs. The reported success rate of conventional therapeutic trials ranged from 17% to 87% and depended on diagnostic criteria, treatment scheme, definition of treatment failure and treatment outcomes that varied substantially between studies. The management of non‐responders differed between studies with a few differential diagnoses reported. No study considered the profile of reflux (acidic, weakly acid, non‐acid or mixed) or addressed personalised treatment with the addition of alginate or magaldrate, low acid diet, or other interventions that have emerging evidence of efficacy.ConclusionTo date, there is no standardised management of LPR patients who do not respond to traditional treatment approached. A diagnostic and therapeutic algorithm is proposed to improve the management of these patients. Future studies will be necessary to confirm the efficacy of this algorithm through large cohort studies of non‐responder LPR patients.Level of evidence2a.
Empty pelvis syndrome: the use of breast prosthesis in the prevention of complications
Authors: Carboni F. , Federici O. , Giofre’ M. , Zazza S. , Valle M. 
Published: June 2019

AbstractAimEmpty pelvis syndrome and radiation‐induced bowel injury are two major clinical issues resulting from the pelvic dead space after pelvic exenteration (PE). In order to avoid these complications, different methods of pelvic floor reconstruction have been proposed. We report our experience on the use of breast prosthesis.MethodFifty‐three patients who underwent PE and three who underwent palliative surgery with silicone breast prosthesis placement were included.ResultsForty‐seven posterior PE, six total PE and three palliative procedures were identified. Sphincter preservation was feasible in 34 patients (62.3%). There were no deaths. Overall morbidity was 37.5%. There were no complications such as sepsis or obstruction related to the prosthesis. Adjuvant radiotherapy was delivered in 16 cases (30.1%) without any side‐effects. Reconstruction of intestinal continuity was possible in 12 patients (36.3%) with sphincter preservation and the prosthesis allowed a prompt identification of the rectal stump.ConclusionBreast prosthesis placement is a simple and safe method to minimize complications resulting from empty pelvis syndrome and can be adopted to exclude bowel loops from the radiation field. Reconstruction of intestinal continuity after resection is also simplified.
Prevention of parastomal hernia after abdominoperineal excision with a prophylactic three‐dimensional funnel mesh
Authors: López‐Borao J. , Madrazo‐González Z. , Kreisler E. , Biondo S. 
Published: June 2019

AbstractAimA prophylactic three‐dimensional (3D) funnel mesh using the keyhole technique (intraperitoneal onlay mesh position) in abdominoperineal excision (APR) may significantly decrease the parastomal hernia (PSH) index without increasing morbidity. The aim of this retrospective observational study was to analyse the incidence of PSH and postoperative complications in patients who underwent permanent colostomy with the use of a prophylactic 3D preformed mesh compared with patients without a mesh.MethodPatients who underwent an end‐colostomy after APR for primary or recurrent rectal cancer in a colorectal surgery unit were divided into two groups: group 1 without a prophylactic mesh and group 2 with a prophylactic synthetic mesh. The main end‐point was to analyse the incidence of PSH after a median follow‐up of 2.8 years.ResultsOne hundred and ten patients (64 in group 1 and 46 in group 2, without significant clinical differences) underwent a permanent colostomy after APR. In group 1 70.3% developed a PSH, compared with 13% in group 2 (P < 0.001). Age (especially for patients ≥ 75 years) represented a significant risk factor for PSH. There were no differences in postoperative complications between the groups.ConclusionA prophylactic parastomal 3D mesh using the keyhole technique may reduce the incidence of PSH after permanent colostomy without an increase in postoperative complications.
Utility of arginine stimulation testing in preoperative assessment of children undergoing total pancreatectomy with islet autotransplantation
Authors: McEachron Kendall R. , Skube Mariya E. , Yang Yi , Hodges James S. , Wilhelm Joshua , Beilman Gregory , Chinnakotla Srinath , Schwarzenberg Sarah J. , Bellin Melena D. 
Published: June 2019

AbstractMetabolic outcomes after total pancreatectomy with islet autotransplantation (TPIAT) are influenced by the islet mass transplanted. Preclinical and clinical studies indicate that insulin and C‐peptide levels measured after intravenous administration of the beta cell secretagogue arginine can be used to estimate the available islet mass. We sought to determine if preoperative arginine stimulation test (AST) results predicted transplanted islet mass and metabolic outcomes in pediatric patients undergoing TPIAT. We evaluated the association of preoperative C‐peptide and insulin responses to AST with islet isolation metrics using linear regression, and with postoperative insulin independence using logistic regression. Twenty‐six TPIAT patients underwent preoperative AST from 2015 to 2018. The acute C‐peptide response to arginine (ACRarg) was correlated with isolated islet equivalents (IEQ; r = 0.59, P = 0.002) and islet number (IPN; r = 0.48, P = 0.013). The acute insulin response to arginine (AIRarg) was not significantly correlated with IEQ (r = 0.38, P = 0.095) or IPN (r = 0.41, P = 0.071). Neither ACRarg nor AIRarg was associated with insulin use at 6 months postoperatively. Preoperative C‐peptide response to arginine correlates with islet mass available for transplant in pediatric TPIAT patients. AST represents an additional tool before autotransplant to provide counseling on likely islet mass and to inform quality improvements of islet isolation techniques.
Does ex vivo perfusion lead to more or less intimal thickening in the first‐year post–heart transplantation?
Authors: Sato Takuma , Azarbal Babak , Cheng Richard , Esmailian Fardad , Patel Jignesh , Kittleson Michelle , Czer Lawrence , Thottam Maria , Levine Ryan , Dimbil Sadia , Olymbios Michael , Anzai Toshihisa , Hamilton Michele A. , Khayal Tamer , Kobashigawa Jon A. 
Published: June 2019

AbstractBackgroundThe Organ Care System (OCS), an ex vivo heart perfusion platform, represents an alternative to the current standard of cold organ storage that sustains the donor heart in a near‐physiologic state. Previous reports showed that this system had significantly shortened the cold ischemic time from standard cold storage (CS). However, the effect of reduced ischemic injury against the coronary vascular bed has not been examined by intravascular ultrasound (IVUS).MethodsBetween August 2011 and February 2013, heart transplant (HTx) candidates enrolled in the PROCEED 2 trial were randomized to either CS or OCS. IVUS was performed at 4‐6 weeks (baseline) and repeated 1 year after transplantation. The change in maximal intimal thickness (MIT) and other clinical outcomes were examined.ResultsThirty‐nine patients were randomized and underwent HTx by OCS (n=16) or CS (n=18). Of these, 18 patients (OCS: n=5, CS: n=13) with paired IVUS were examined. There were no significant differences in the change of MIT and other clinical outcomes between the groups.ConclusionThe incidence of cardiac allograft vasculopathy in donor hearts preserved with the OCS versus CS was similar. These results suggest that this ex vivo allograft perfusion system is a promising and valid platform for donor heart transportation.
Long‐term impact of dialysis‐requiring AKI during the perioperative period of liver transplantation on postdischarge outcomes
Authors: Lee Soojin , Park Sehoon , Kang Min Woo , Yoo Hai‐Won , Han Kyungdo , Kim Yaerim , Lee Jung Pyo , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Kim Hyeongsu , Kim Dong Ki 
Published: June 2019

AbstractBackgroundPatients undergoing liver transplantation (LT) are prone to dialysis‐requiring acute kidney injury (AKI‐D). However, long‐term prognoses among them need further investigation, as overall survival after LT is improving.MethodsA nationwide, population‐based cohort study was conducted using the data of Korean National Health Insurance System between 2006 and 2015. The patients who received dialysis during the perioperative period of LT were in the AKI‐D group, and the control group included those who did not undergo dialysis.ResultsAmong the 6879 patients who underwent LT, 968 were in the AKI‐D group. All‐cause mortality [adjusted hazard ratio (HR): 1.52 (1.26‐1.83), P < 0.001], end‐stage renal disease (ESRD) progression [adjusted HR: 2.93 (2.34‐3.66), P < 0.001], and ICU readmission [adjusted HR: 1.70 (1.44‐2.01), P < 0.001] within and after 90 days from discharge were increased in the AKI‐D group. When analyzed among those who recovered from dialysis at discharge, overall outcomes were similar to those of the AKI‐D group, except the long‐term mortality.ConclusionsAKI‐D during the perioperative period of LT was associated with worse mortality, ESRD progression, and ICU readmission risk. The results of renal‐recovered patients could indicate clinicians that achievement of dialysis independence is important to gain favorable long‐term postdischarge survival.
Post‐transplant lymphoproliferative disorders, Epstein‐Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice
Authors: Allen Upton D. , Preiksaitis Jutta K. ,   the AST Infectious Diseases Community of Practice
Published: June 2019

AbstractThese updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice review the diagnosis, management, and prevention of post‐transplant lymphoproliferative disorders (PTLD) and other Epstein‐Barr virus (EBV) syndromes after solid organ transplantation. PTLD are a heterogeneous spectrum of predominantly B‐cell disorders, often extra‐nodal, with complex distinct pathogeneses and variable clinical presentations determined by pathologic subtype. Recent epidemiologic studies report a decrease in early EBV‐positive (+) PTLD and an increase in late EBV‐negative (−) PTLD. Pre‐transplant EBV‐seronegativity and primary EBV infection, often from donor‐transmitted infection, are an important risk factors for EBV syndromes and early EBV + PTLD. Low‐quality evidence supports preemptive prevention strategies for early EBV + PTLD in EBV‐seronegative recipients that involve EBV DNA measurement in peripheral blood using assays requiring further result harmonization, combined with interventions to lower viral load. Reduction in immunosuppression (RIS) is the best validated intervention. WHO pathology classification of a tissue biopsy remains the gold standard for PTLD diagnosis; optimal staging procedures are uncertain. Treatment of CD20+ PTLD with the response‐dependent sequential use of RIS, rituximab, and cytotoxic chemotherapy is recommended. Evidence gaps requiring future research and alternate treatment strategies including immunotherapy are highlighted.
Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder: a prospective 2‐year follow‐up study
Authors: Shin C. , Lee J.‐Y. , Kim Y. K. , Nam H. , Yoon E. J. , Shin S. A. , Kim H.‐J. , Jeon B. 
Published: June 2019

Background and purposeThe aim was to analyze the characteristics and progression of cognitive dysfunction in non‐demented idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with baseline olfactory function.MethodsFrom a prospective polysomnography‐confirmed iRBD cohort, 25 patients (16 patients in 2‐year follow‐up) and 13 normal controls were included. Initial and 2‐year follow‐up cognitive functions were analyzed with olfactory function and 18F‐fluorinated‐N‐3‐fluoropropyl‐2β‐carboxymethoxy‐3β‐(4‐iodophenyl)‐nortropane (18F‐FP‐CIT) uptake in deep nuclei initially.ResultsIdiopathic RBD patients had impaired attention, memory and executive function compared to controls. Baseline cognitive tests were comparable between the iRBD subgroups with and without hyposmia. 18F‐FP‐CIT uptake tended to be lower in the hyposmic group than in the normosmic group. The olfactory test score was positively correlated with amygdala uptake in iRBD patients (P = 0.027). After 2 years, visuospatial and verbal memory dysfunction worsened more in hyposmics than in normosmics. Lower initial olfactory test score was associated with more severe declines in verbal memory function.ConclusionsHyposmia may be a predictive sign of cognitive decline in iRBD patients.
Cash holdings in family firms: CEO identity and implications for firm value
Authors: Caprio Lorenzo , Del Giudice Alfonso , Signori Andrea 
Published: June 2019

AbstractWe investigate the cash holdings policy of family firms and examine potential value implications. Family firms hold more cash than other firms, with an average difference of 2.3% of total assets. This result is driven by firms managed by heir CEOs. While the cash holdings policy of first‐generation family firms is more sensitive to firm risk, consistent with founders’ increased risk aversion, that of later‐generation firms is more sensitive to information asymmetry and agency conflicts. Heir CEOs’ cash policies destroy value, as the marginal value of an additional Euro suffers from a 38.3‐cent discount, on average, relative to non‐family firms.