bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Bothersome Lower Urinary Tract Symptoms in Middle-Aged Men Receiving Health Checkup
Authors: Yang Teng-Kai , Chang Chi-Chih , Chang Hong-Chiang , Yang Hung-Ju , Huang Kuo-How 
Published: January 2019

AbstractThe prospective study is to investigate the associations between serum testosterone levels and LUTS among middle-aged men ≥40 years receiving health check-up. Lower urinary tract symptoms were evaluated by the self-administered International Prostate Symptom Score questionnaire. Serum prostate specific antigen and total testosterone level were checked in all subjects. A total of 1752 men were enrolled into the study. The mean age was 55.6 ± 9.7 years. All study subjects were stratified into low, medium and high testosterone levels by two cut-off, 3.0 and 4.11 ng/mL. We found that testosterone levels were significantly associated with metabolic syndrome and body fat components. Compared to those with low testosterone levels, subjects with high and medium testosterone had a significantly higher IPSS (5.84 ± 5.55 vs 6.71 ± 5.68 and 6.34 ± 5.66, p = 0.032) and storage score (2.76 ± 2.29 vs 3.20 ± 2.49 and 2.90 ± 2.49; p = 0.009), and a more moderate/severe LUTS (IPSS ≧ 8) (26.5% vs 35.7% and 29.9%; p = 0.002). Multivariate analyses showed that high vs low testosterone levels (OR, 1.76; 95% CI, 1.26–2.45) and prostate volume ≧25 vs <25 mL (OR, 1.38; 95% CI, 1.04–1.82) significantly associated with the presence of moderate/severe LUTS. Pearson correlation analyses showed significantly positive correlations between testosterone level and IPSS in whole study sample (Pearson correlation coefficient, 0.066; p < 0.01) and in the subgroup of moderate/severe LUTS (Pearson correlation coefficient, 0.038; p < 0.05). In conclusion, high testosterone and prostate volume adversely impacted LUTS in our target population.
Manually-parcellated gyral data accounting for all known anatomical variability
Authors: Mikhael Shadia S. , Mair Grant , Valdes-Hernandez Maria , Hoogendoorn Corné , Wardlaw Joanna M. , Bastin Mark E. , Pernet Cyril 
Published: January 2019

AbstractMorphometric brain changes occur throughout the lifetime and are often investigated to understand healthy ageing and disease, to identify novel biomarkers, and to classify patient groups. Yet, to accurately characterise such changes, an accurate parcellation of the brain must be achieved. Here, we present a manually-parcellated dataset of the superior frontal, the supramarginal, and the cingulate gyri of 10 healthy middle-aged subjects along with a fully detailed protocol based on two anatomical atlases. Gyral parcels were hand-drawn then reviewed by specialists blinded from the protocol to ensure consistency. Importantly, we follow a procedure that allows accounting for anatomical variability beyond what is usually achieved by standard analysis packages and avoids mutually referring to neighbouring gyri when defining gyral edges. We also provide grey matter thickness, grey matter volume, and white matter surface area information for each parcel. This dataset and corresponding measurements are useful in assessing the accuracy of equivalent parcels and metrics generated by image analysis tools and their impact on morphometric studies.
An X-ray computed micro-tomography dataset for oil removal from carbonate porous media
Authors: Pak Tannaz , Archilha Nathaly Lopes , Mantovani Iara Frangiotti , Moreira Anderson Camargo , Butler Ian B. 
Published: January 2019

AbstractThis study reveals the pore-scale details of oil mobilisation and recovery from a carbonate rock upon injection of aqueous nanoparticle (NP) suspensions. X-ray computed micro-tomography (μCT), which is a non-destructive imaging technique, was used to acquire a dataset which includes: (i) 3D images of the sample collected at the end of fluid injection steps, and (ii) 2D radiogram series collected during fluid injections. The latter allows monitoring fluid flow dynamics at time resolutions down to a few seconds using a laboratory-based μCT scanner. By making this dataset publicly available we enable (i) new image reconstruction algorithms to be tested on large images, (ii) further development of image segmentation algorithms based on machine learning, and (iii) new models for multi-phase fluid displacements in porous media to be evaluated using images of a dynamic process in a naturally occurring and complex material. This dataset is comprehensive in that it offers a series of images that were captured before/during/and after the immiscible fluid injections.
Ferritin exhibits Michaelis–Menten behavior with oxygen but not with iron during iron oxidation and core mineralization
Authors: Bou-Abdallah Fadi , Flint Nicholas , Wilkinson Tyler , Salim Samantha , Srivastava Ayush Kumar , Poli Maura , Arosio Paolo , Melman Artem 
Published: January 2019

Abstract
The excessively high and inconsistent literature values for Km,Fe and Km,O2 prompted us to examine the iron oxidation kinetics in ferritin, the major iron storage protein in mammals, and to determine whether a traditional Michaelis–Menten enzymatic behavior is obeyed. The kinetics of Fe(ii) oxidation and mineralization catalyzed by three different types of ferritins (recombinant human homopolymer 24H, HuHF, human heteropolymer ∼21H:3L, HL, and horse spleen heteropolymer ∼3.3H:20.7L, HosF) were therefore studied under physiologically relevant O2 concentrations, but also in the presence of excess Fe(ii) and O2 concentrations. The observed iron oxidation kinetics exhibited two distinct phases (phase I and phase II), neither of which obeyed Michaelis–Menten kinetics. While phase I was very rapid and corresponded to the oxidation of approximately 2 Fe(ii) ions per H-subunit, phase II was much slower and varied linearly with the concentration of iron(ii) cations in solution, independent of the size of the iron core. Under low oxygen concentration close to physiological, the iron uptake kinetics revealed a Michaelis–Menten behavior with Km,O2 values in the low μM range (i.e. ∼1–2 μM range). Our experimental Km,O2 values are significantly lower than typical cellular oxygen concentration, indicating that iron oxidation and mineralization in ferritin should not be affected by the oxygenation level of cells, and should proceed even under hypoxic events. A kinetic model is proposed in which the inhibition of the protein’s activity is caused by bound iron(iii) cations at the ferroxidase center, with the rate limiting step corresponding to an exchange or a displacement reaction between incoming Fe(ii) cations and bound Fe(iii) cations.
Conversation in Aphasia Across Communication Partners: Exploring Stability of Microlinguistic Measures and Communicative Success
Authors: Leaman Marion C. , Edmonds Lisa A. 
Published: January 2019

PurposeThe aim of this study was to determine if people with aphasia demonstrate differences in microlinguistic skills and communicative success in unstructured, nontherapeutic conversations with a home communication partner (Home-P) as compared to a speech-language pathologist communication partner (SLP-P).MethodEight persons with aphasia participated in 2 unstructured, nontherapeutic 15-minute conversations, 1 each with an unfamiliar SLP-P and a Home-P. Utterance-level analysis evaluated communicative success. Two narrow measures of lexical relevance and sentence frame were used to evaluate independent clauses. Two broad lexical and morphosyntactic measures were used to evaluate elliptical and dependent clauses and to evaluate independent clauses for errors beyond lexical relevance and sentence frame (such as phonological and morphosyntactic errors). Utterances were further evaluated for presence of behaviors indicating lexical retrieval difficulty (pauses, repetitions, and false starts) and for referential cohesion.ResultsNo statistical differences occurred for communicative success or for any of the microlinguistic measures between the SLP-P and Home-P conversation conditions. Four measures (2 of lexical retrieval and 1 each of communicative success and grammaticality) showed high correlations across the 2 conversation samples. Individuals showed variation of no more than 10 percentage points between the 2 conversation conditions for 46 of 56 data points. Variation greater than 10 percentage points tended to occur for the measure of referential cohesion and primarily for 1 participant.ConclusionsPreliminary findings suggest that these microlinguistic measures and communicative success have potential for reliable comparison across Home-P and SLP-P conversations, with the possible exception of referential cohesion. However, further research is needed with a larger, more diverse sample. These findings suggest future assessment and treatment implications for clinical and research needs.Supplemental Materialhttps://doi.org/10.23641/asha.7616312
Telepractice for School-Based Speech and Language Services: A Workload Management Strategy
Authors: Boisvert Michelle K. , Hall Nerissa 
Published: January 2019

Purpose
This article discusses the combination of onsite and telepractice services as an effective way for professionals working in multiple schools to maximize their time and professional services in an effort to manage their workload. The combined onsite and telepractice services were used by district-wide school-based professionals to deliver direct and indirect services across various locations, thereby reducing time-consuming travel and increasing scheduling efficiency. The possible uses of telepractice as a workload management tool are discussed, as well as some challenges that the team overcame in order to successfully use this method.

Conclusions
Telepractice, in combination with onsite services, is an effective workload strategy for school-based therapists.
Wideband filtering power divider with wide rejection bandwidth and isolation
Authors: Hao Honggang , Ni Xingrui 
Published: January 2019

A wideband filtering power divider (FPD) with wide rejection bandwidth and good isolation is presented, based on conventional Wilkinson structure. Parallel coupled lines and two pairs of open‐circuit stubs are used for achieving bandpass filtering response and enhancing the performance of the rejection bandwidth. Furthermore, by properly choosing two resistors between two pairs of open‐circuit stubs allows good isolation performance. Measured results indicate that the FPD operates at 2.35 GHz (f0) with a − 20 dB bandwidth of 55.3%. In the upper stopband range from 3.7 to 8.8 GHz (3.74f0), the minimum rejection is 20 dB. Within working band, the isolation between the output ports is higher than 24 dB. In addition, ultra‐wide isolation better than 20 dB from DC to 10 GHz is obtained.
The CARMENES search for exoplanets around M dwarfs
Authors: Schöfer P. , Jeffers S. V. , Reiners A. , Shulyak D. , Fuhrmeister B. , Johnson E. N. , Zechmeister M. , Ribas I. , Quirrenbach A. , Amado P. J. , Caballero J. A. , Anglada-Escudé G. , Bauer F. F. , Béjar V. J. S. , Cortés-Contreras M. , Dreizler S. , Guenther E. W. , Kaminski A. , Kürster M. , Lafarga M. , Montes D. , Morales J. C. , Pedraz S. , Tal-Or L. 
Published: January 2019

Context. The Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical Echelle Spectrographs (CARMENES) survey is searching for Earth-like planets orbiting M dwarfs using the radial velocity method. Studying the stellar activity of the target stars is important to avoid false planet detections and to improve our understanding of the atmospheres of late-type stars.
Aims. In this work we present measurements of activity indicators at visible and near-infrared wavelengths for 331 M dwarfs observed with CARMENES. Our aim is to identify the activity indicators that are most sensitive and easiest to measure, and the correlations among these indicators. We also wish to characterise their variability.
Methods. Using a spectral subtraction technique, we measured pseudo-equivalent widths of the He I D3, Hα, He I λ10833 Å, and Pa β lines, the Na I D doublet, and the Ca II infrared triplet, which have a chromospheric component in active M dwarfs. In addition, we measured an index of the strength of two TiO and two VO bands, which are formed in the photosphere. We also searched for periodicities in these activity indicators for all sample stars using generalised Lomb-Scargle periodograms.
Results. We find that the most slowly rotating stars of each spectral subtype have the strongest Hα absorption. Hα is correlated most strongly with He I D3, whereas Na I D and the Ca II infrared triplet are also correlated with Hα. He I λ10833 Å and Paβ show no clear correlations with the other indicators. The TiO bands show an activity effect that does not appear in the VO bands. We find that the relative variations of Hα and He I D3 are smaller for stars with higher activity levels, while this anti-correlation is weaker for Na I D and the Ca II infrared triplet, and is absent for He I λ10833 Å and Paβ. Periodic variation with the rotation period most commonly appears in the TiO bands, Hα, and in the Ca II infrared triplet.
Posterior Interosseous Neurectomy Alternative for Treating Chronic Wrist Pain
Authors: Abdelaziz Ashraf M. , Aldahshan Wael , El-Sherief Faisal Ahmed Hashem , Wahd Yaser El Sayed Hassan , Soliman Hany Abdel Gawwad 
Published: January 2019

Background Wrist denervation is one of the several available options for treating chronic wrist pain; partial wrist denervation performed through a single dorsal incision by resecting the distal posterior interosseous nerve provides good outcomes.
Questions/Purposes This study evaluated the results of posterior interosseous neurectomy (PIN) in patients with chronic wrist pain secondary to scaphoid nonunion advanced collapse (SNAC) and scapholunate advanced collapse (SLAC).
Methods In total, 30 wrists obtained from 28 patients (25 males, 3 females) were assessed. The dominant hands of 25 (right-handed) patients, nondominant hands of 5, and both hands of 2 were considered. The average age at the time of surgery was 35 (range: 19–50) years, and the average follow-up duration was 18 (range: 12–30) months. Fifteen and 13 patients had wrists with SNAC and SLAC, respectively, and all of those underwent PIN performed through the dorsal approach. The pre- and postoperative range of motion, grip strength, and pain relief percentage were recorded for all the 30 wrists.
Results The average postoperative Disabilities of the Arm, Shoulder and Hand score was 30 (range: 20–80), and the difference between the pre- and postoperative scores was statistically significant. Ninety percent of the patients were satisfied with the results of PIN and reported improvement in grip strength and pain relief.
Conclusions Thus, PIN may be an effective surgical technique for wrist reconstruction.
Clinical Relevance To help patients challenge pain and maintain their wrist joint range of motion.
Fighting misinformation on social media using crowdsourced judgments of news source quality
Authors: Pennycook Gordon , Rand David G. 
Published: January 2019

SignificanceMany people consume news via social media. It is therefore desirable to reduce social media users’ exposure to low-quality news content. One possible intervention is for social media ranking algorithms to show relatively less content from sources that users deem to be untrustworthy. But are laypeople’s judgments reliable indicators of quality, or are they corrupted by either partisan bias or lack of information? Perhaps surprisingly, we find that laypeople—on average—are quite good at distinguishing between lower- and higher-quality sources. These results indicate that incorporating the trust ratings of laypeople into social media ranking algorithms may prove an effective intervention against misinformation, fake news, and news content with heavy political bias.
Developmental trajectory of social influence integration into perceptual decisions in children
Authors: Large Imogen , Pellicano Elizabeth , Mojzisch Andreas , Krug Kristine 
Published: January 2019

Significance
Social influence biases even simple perceptual decisions across a range of contexts. The development and mechanism of such biases remain unclear. We systematically examined the developmental course of social influence bias exerted by another person on perceptual decisions in children between 6 and 14 years old. To probe underlying mechanisms, we applied the computational model drift diffusion to behavioral response data. Our results show that although young neurotypical children seem to be unaffected by social influence, adolescents develop a systematic bias of their responses in the direction of social influence and appear to do so by integrating social information into visual perceptual processing. The same pattern of results did not emerge in age-matched autistic children, suggesting a different developmental trajectory.
Agent-based representations of objects and actions in the monkey pre-supplementary motor area
Authors: Livi Alessandro , Lanzilotto Marco , Maranesi Monica , Fogassi Leonardo , Rizzolatti Giacomo , Bonini Luca 
Published: January 2019

Significance
Social animals exploit information about objects for planning actions and for predicting those of others. Here, we show that pre-supplementary motor area F6 hosts different types of neurons responding to visually presented objects when they are targeted by the monkey’s own action (self-type), another agent’s action (other-type), or both (self- and other-type). These findings suggest the existence in area F6 of an “object-mirroring” mechanism, which allows observers to predict others’ impending action by recruiting the same motor representation they would use for planning their own action in the same context, before the activation of classical “action-mirroring” mechanisms.
Fanconi anemia protein FANCI functions in ribosome biogenesis
Authors: Sondalle Samuel B. , Longerich Simonne , Ogawa Lisa M. , Sung Patrick , Baserga Susan J. 
Published: January 2019

Significance
FANCI is a Fanconi anemia (FA) protein and functions in DNA interstrand cross-link repair. Surprisingly, in addition to DNA repair proteins, we find that FANCI interacts with proteins that function in ribosome biogenesis, the synthesis of ribosomes in cells. Furthermore, FANCI localizes to the nucleolus—the cellular compartment in which ribosome biogenesis initiates—and functions in the transcription and processing of pre-ribosomal RNA (pre-rRNA). Interestingly, defects in ribosome biogenesis underlie three other bone marrow failure syndromes, raising the question, Do defects in ribosome biogenesis contribute to FA pathogenesis? Our results expand the functions of FANCI to encompass ribosome biogenesis and DNA repair, highlighting the importance of future investigations into the role of other FA proteins in synthesizing ribosomes.
Transitions between foot postures are associated with elevated rates of body size evolution in mammals
Authors: Kubo Tai , Sakamoto Manabu , Meade Andrew , Venditti Chris 
Published: January 2019

Significance
Terrestrial mammals have evolved diverse foot postures, contributing to their ecological success. Yet, how postures evolved and how they affected body size evolution remain largely unknown. Here we statistically reconstruct the paths and trajectories in foot posture evolution and explicitly test the effects of posture on body size evolution, using phylogenetic Bayesian approaches. We found that upright foot postures evolved in a directional manner, from flat-footed ancestors, to tiptoed, and then to hooved descendants. Furthermore, transitions to different foot postures are associated with increases in rates of body size evolution, rapidly leading to larger descendants, demonstrating how transitions between foot postures have had profound influences on mammalian body size evolution.
IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation
Authors: Ameri Amir H. , Moradi Tuchayi Sara , Zaalberg Anniek , Park Jong Ho , Ngo Kenneth H. , Li Tiancheng , Lopez Elena , Colonna Marco , Lee Richard T. , Mino-Kenudson Mari , Demehri Shadmehr 
Published: January 2019

Significance
Chronic inflammatory diseases are well-recognized causes of cancer and account for up to 20% of all cancer deaths worldwide. However, the mechanism that initiates the development of a tumor-promoting immune environment in chronic inflammation is not known. Using mouse models of chronic skin and colon inflammation and human samples, we show IL-33 triggers the transition from tumor-suppressive immunity to chronic, tumor-promoting inflammation through a regulatory T cell-dependent mechanism. Our findings demonstrate a generalized dependency of tumor-promoting immune environments on the IL-33/Treg axis both in the skin and colon. Based on these findings, IL-33/Treg axis blockade may be an attractive therapeutic strategy for the treatment and prevention of cancers associated with chronic inflammatory diseases and potentiating the antitumor immunity induced by cancer immunotherapeutics.
Stimulus complexity shapes response correlations in primary visual cortex
Authors: Bányai Mihály , Lazar Andreea , Klein Liane , Klon-Lipok Johanna , Stippinger Marcell , Singer Wolf , Orbán Gergő 
Published: January 2019

Significance
Whether the population activity in neuronal networks can be understood as the sum of individual activities or neurons jointly determine the state of populations is a fundamental question of neuroscience. Spike count correlations reflect coordination between pairs of neurons and therefore can be regarded as a signature of joint computations. So far, a majority of experimental and theoretical analyses considered these correlations noise and ignored stimulus-dependent aspects. Based on theoretical considerations, we argue that spike count correlations are stimulus dependent and variations in their structure can be predicted by stimulus content. Recording the activity of neurons from primary visual cortex in task-engaged monkeys, we confirm these predictions. These results provide insight into the computations performed by populations of cortical neurons.
Directional pumping of water and oil microdroplets on slippery surface
Authors: Jiang Jieke , Gao Jun , Zhang Hengdi , He Wenqing , Zhang Jianqiang , Daniel Dan , Yao Xi 
Published: January 2019

Significance
Driving liquid microdroplets has been challenging due to the large contact angle hysteresis and insufficient driving force at microscale. We designed a strategy to directionally transport water and oil microdroplets. By simply mounting hydrogel dots on a slippery surface to arrest lubricant menisci, spontaneously formed capillary force pumps liquid microdroplets continuously at high efficiency. Such strategy is universally applicable to water and oil droplets of different surface tensions and different sizes, yet with little substrate preparation effort. Furthermore, we demonstrated its applications in highly efficient water droplet collection and biomedical sample enrichment for highly sensitive detection. Our technique may be useful in water harvesting, droplet condensation, and biomedical analysis.
The glutathione cycle shapes synaptic glutamate activity
Authors: Sedlak Thomas W. , Paul Bindu D. , Parker Gregory M. , Hester Lynda D. , Snowman Adele M. , Taniguchi Yu , Kamiya Atsushi , Snyder Solomon H. , Sawa Akira 
Published: January 2019

SignificanceGlutathione is a major antioxidant and redox regulator in cells. In addition to its essential roles in redox homeostasis, it functions as cofactors for a multitude of enzymes. We show here that the glutathione cycle molds the activity of synaptic glutamate, the major excitatory neurotransmitter in the central nervous system. Deficits in glutathione have been linked to multiple neurodegenerative and neuropsychiatric disorders. Accordingly, agents that restore glutathione-glutamate homeostasis may afford therapeutic benefit.