bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Inflammation, Systemic Inflammation, and Cardiovascular Disease in Psoriasis
Authors: Svedbom Axel , Mallbris Lotus , González-Cantero Álvaro , Playford Martin , Wu Colin , Mehta Nehal N. , Ståhle Mona 
Published: November 2024

ImportancePsoriasis is associated with increased cardiovascular risk, but the underlying pathogenic mechanisms remain unclear. Elucidating these mechanisms can help develop treatment strategies and enhance understanding of the link between peripheral inflammation, such as psoriatic skin lesions, and cardiovascular disease (CVD).ObjectiveTo explore whether systemic inflammation is a mediator of the association between psoriasis skin disease severity and CVD.Design, Setting, and ParticipantsThis cohort study used data from cross-sectional study (Psoriasis Atherosclerosis and Cardiometabolic Disease Initiative [PACI]), which enrolled patients from January 2013 to February 2022, and an inception cohort study (Stockholm Psoriasis Cohort [SPC]), which enrolled patients from January 2000 to December 2005. The PACI enrolled consecutive patients referred by dermatologists in Maryland, and the SPC enrolled consecutive patients referred from a wide range of practices in Sweden. Patients with prevalent psoriasis from the PACI and patients with incident psoriasis from the SPC were included. Data were analyzed from October 2023 to January 2024.ExposuresPsoriasis skin disease severity was measured using the Psoriasis Area and Severity Index (PASI), and systemic inflammation was measured using glycan biomarker of N-acetyl side chains of acute-phase proteins (GlycA). Mediation analysis was performed by evaluating the associations between exposure, mediator, and outcome in patients with first-tertile and third-tertile PASI scores when GlycA level was set at the level observed in patients with first-tertile PASI.Main Outcomes and MeasuresNoncalcified coronary burden (NCB) measured using coronary computed tomography angiography in the PACI and hospitalization for CVD or cardiovascular death in the SPC.ResultsOf 260 eligible patients from the PACI, 162 (62.3%) were male, and the median (IQR) age was 51 (41-60) years; of 509 eligible patients from the SPC, 237 (46.6%) were male, and the median (IQR) age was 43 (30-57) years. In both studies, PASI was associated with GlycA level and CVD, and GlycA level was associated with CVD. The direct and indirect (through GlycA) effects of PASI on NCB were estimated at 0.94 (95% CI, 0.26-1.74) and 0.19 (95% CI, 0.02-0.47), respectively. The odds ratios for the direct and indirect effects of PASI on cardiovascular events were estimated at 1.23 (95% CI, 0.70-1.92) and 1.16 (95% CI, 1.04-1.42), respectively.Conclusions and RelevanceIn this study, skin disease severity measured using PASI was associated with systemic inflammation, and both PASI and systemic inflammation, measured using GlycA levels, were associated with CVD. The association between PASI and CVD may be mediated by systemic inflammation.
Designing Ultra‐Stable and Surface‐Exposed Ni Nanoparticles with Dually Confined Microenvironment for High‐Temperature Methane Dry Reforming
Authors: He Dedong , Zhang Yimin , Li Tan , Chen Dingkai , Wang Hao , Zhang Lei , Liu Jiangping , Cao Xiaohua , Lu Jichang , Luo Yongming 
Published: November 2024

AbstractConversion of CO2 and CH4 into syngas offers a promising route to reduce emissions of greenhouse gases, which facilitates large‐scale carbon fixation and boosts carbon‐neutral goal. The main obstacle for CO2/CH4 reforming is the lack of durable catalysts showing both high metal‐exposure and high‐temperature structure stability, since the reported Ni‐based catalysts have difficulty in avoiding deactivation by sintering metal at high temperature. Herein, ultra‐small Ni nanoparticles, which display multiple characteristics of high surface‐exposure and stabilized structure, are constructed from the evolution of atomically dispersed low‐valent nickel under a dually confined microenvironment. Consequently, the developed strategy can not only break the stable‐exposure trade‐off in heterogeneous catalysis but also provide new opportunity for the engineering of high‐performance and sintering‐resistant reforming catalysts as well as other durable heterogeneous catalysts.
Multifunctional Molecule Passivated Quasi‐2D Perovskite Film for Efficient and Stable Luminescent Solar Concentrator
Authors: Sun Mingze , Chen Ying , Tian Shubing , Zhang Mingming , Jiang Haokun , Liu Kang , Xu Jixiang , Dai Fangxu , Wang Lei , Zhou Zhongmin , Xing Jun 
Published: November 2024

AbstractQuasi−2D perovskite films with multiple quantum well structures can provide a large Stokes shift and efficient photoluminescence (PL), which have great potential in the application of luminescent solar concentrators (LSCs). However, its low photoelectric conversion efficiency and poor stability remain obstacles to commercial application. Here, a multifunctional molecule additive octyltriphenylphosphonium bromide is introduced to prepare high‐quality perovskite LSCs. The multifunctional molecule can simultaneously passivate perovskite cations and anions, reducing the defect sites and improving the photoluminescence quantum yield (PLQY) of the perovskite nanocrystals. Triphenylphosphine groups with high steric hindrance effect can hinder ion migration; the hydrophobic properties of the long alkyl chain prevent water erosion, which together improves the stability of the perovskite films. The multifunctional molecule passivated perovskite film has a high PLQY of 100% and retains 96% of the initial PL intensity after 30 days of indoor storage. The perovskite LSC device achieves a maximum optical efficiency of 6.5% at a geometric factor of 3.1. The findings open a new way to boost the performance of perovskite‐based LSCs.
MCL1 Inhibitor Augmented the Anti‐Glioma Efficacy of Paclitaxel Utilizing a Multifunctional Cascade Nanodrug System
Authors: Zhang Rui , Zhang Si , Zhang Zhenyu , Zhang Yunchu , Yi Linbin , Cheng Yongzhong , Qian Zhiyong , Zan Xin , Gao Xiang 
Published: November 2024

AbstractDespite the importance of chemotherapy as a treatment option for glioma, its efficacy is often compromised by the formidable blood‐brain barrier (BBB) and drug resistance. To address these challenges, a novel cascade nanodrug system called A12‐PTX@RF‐NPs is designed with aims to penetrate the BBB and precisely target glioma. In this nanosystem, the RVG‐29 peptide facilitates the BBB penetration while Folic Acid (FA) targets glioma cells through binding to Folate Receptors (FR), followed by receptor‐mediated endocytosis subsequently. The incorporation of disulfide bond modifications enables responsive release within the reductive environment of glioma, ensuring successful delivery of chemotherapy drugs. Significantly, a co‐treatment approach involving the combination of A12 and PTX is implemented. In vitro and in vivo investigations have provided evidence that this amalgamation effectively induces apoptosis in tumor cells and inhibits their proliferation, thus synergistically eliminating both typical and drug‐resistant glioma cells. These findings suggest that the nanodrug system presents a promising therapeutic strategy for glioma treatment, surpassing the limitations of conventional chemotherapy. Specifically, A12‐PTX@RF‐NPs constructed in this research have demonstrated remarkable targeting capabilities and therapeutic effects in cellular as well as animal models, thereby proposing an innovative strategy for glioma treatment.
Molecule‐Induced Huge d‐p Overlap Enhances Superexchange Interaction for Room‐Temperature In‐Plane Magnetism and Giant Magneto Band‐Structure Effect in Ferromagnetic Clusterphene
Authors: Liu Xiaofeng , Bai Yihang , Zhu Weiduo , Liu Zhao , Chen Zhao , Gao Pengfei , Wang Haidi , Li Zhongjun , Wang Bing , Li Xingxing , Hu Wei , Yang Jinlong 
Published: November 2024

AbstractThe discovery of 2D van der Waals XY ferromagnets is a vital task to access excellent topological spin textures, yet remains a longstanding challenge due to low critical temperatures (TC) and weak in‐plane magnetic anisotropy. Here, a novel 2D ferromagnetic clusterphene, (Cr3As2)2Cp3 (Cp = cyclopentadienyl), by using Cr3As2Cp3 cluster self‐assembly with Cp as linker is proposed. Via first‐principles calculations, it is demonstrated that an enhanced ferromagnetic superexchange interaction between the d orbital is achieved through a salient overlap onto the molecular frontier orbitals of the Cp ligand, producing a room‐temperature TC. The (Cr3As2)2Cp3 clusterphene characterizes an ideal XY ferromagnet and a giant magneto band‐structure (GMB) effect. Functional groups and element modifications are also introduced to effectively manipulate the magnetic anisotropy and the GMB effect. The results showcase that 2D magnetic cluster‐assembled clusterphenes fuel a wide range of possibilities for exploring XY magnetism in reduced dimensions.
Direction‐Decoupled Light‐Emitting Metasurface via Guided‐Photoluminescence Manipulation
Authors: Wang Zejing , Wan Shuai , Dai Chenjie , Li Zhe , Li Zhongyang 
Published: November 2024

AbstractOn‐demand manipulation of light emissions is crucial for a variety of practical applications, including bio‐imaging and optical display, etc. Within this realm, the invention of metasurfaces provides powerful light–matter interaction capabilities for the control of multitudinous emission parameters. However, due to the omnidirectional, random, and incoherent nature of photoluminescence (PL) emission, the multiplexing modulation of PL remains a challenge and is rarely realized. Here, a direction‐decoupled light‐emitting metasurface (LEM) is originally demonstrated to display dual‐channel independent incoherent‐emission images based on guided‐PL manipulation. Utilizing the wavevector differences of guided‐PL between opposite pumping directions, the LEM is designed to enable selective unidirectional emission, thereby decoupling the directional freedom for PL multiplexing and realizing dual meta‐display. Besides, the direction‐multiplexed LEM can be integrated simultaneously with pumping‐light holography for multi‐dimensional meta‐display. Such programmable unidirectional emission manipulation and direction‐multiplexed PL meta‐display approaches promise light‐emitting techniques and can potentially find applications in multiplexing display, optical storage and encryption, etc.
Achieving Large and Anisotropic Spin‐Mediated Thermal Transport in Textured Quantum Magnets
Authors: Guo Shucheng , Bai Xue , Liang Boqun , Hoke Thomas , Liu Ming , Dunin‐Borkowski Rafal E. , Chen Xi 
Published: November 2024

AbstractSpin excitations, including magnons and spinons, can carry thermal energy and spin information. Studying spin‐mediated thermal transport is crucial for spin caloritronics, enabling efficient heat dissipation in microelectronics and advanced thermoelectric applications. However, designing quantum materials with controllable spin transport is challenging. Here, highly textured spin‐chain compound Ca2CuO3 is synthesized using a solvent‐cast cold pressing technique, aligning 2D nanostructures with spin chains perpendicular to the pressing direction. The sample exhibits high thermal conductivity anisotropy and an excellent room‐temperature thermal conductivity of 12 ± 0.7 W m−1 K−1, surpassing all polycrystalline quantum magnets. Such a high value is attributed to the significant spin‐mediated thermal conductivity of 10 ± 1 W m−1 K−1, the highest reported among all polycrystalline quantum materials. Analysis through a 1D kinetic model suggests that near room‐temperature, spinon thermal transport is dominated by coupling with high‐frequency phonons, while extrinsic spinon‐defect scattering is negligible. Additionally, this method is used to prepare textured La2CuO4, exhibiting highly anisotropic magnon thermal transport and demonstrating its broad applicability. A distinct role of defect scattering in spin‐mediated thermal transport is observed in two spin systems. These findings open new avenues for designing quantum materials with controlled spin transport for thermal management and energy conversion.
Printed High‐Entropy Prussian Blue Analogs for Advanced Non‐Volatile Memristive Devices
Authors: He Yueyue , Ting Yin‐Ying , Hu Hongrong , Diemant Thomas , Dai Yuting , Lin Jing , Schweidler Simon , Marques Gabriel Cadilha , Hahn Horst , Ma Yanjiao , Brezesinski Torsten , Kowalski Piotr M. , Breitung Ben , Aghassi‐Hagmann Jasmin 
Published: November 2024

AbstractNon‐volatile memristors dynamically switch between high (HRS) and low resistance states (LRS) in response to electrical stimuli, essential for electronic memories, neuromorphic computing, and artificial intelligence. High‐entropy Prussian blue analogs (HE‐PBAs) are promising insertion‐type battery materials due to their diverse composition, high structural integrity, and favorable ionic conductivity. This work proposes a non‐volatile, bipolar memristor based on HE‐PBA. The device, featuring an active layer of HE‐PBA sandwiched between Ag and ITO electrodes, is fabricated by inkjet printing and microplotting. The conduction mechanism of the Ag/HE‐PBA/ITO device is systematically investigated. The results indicate that the transition between HRS and LRS is driven by an insulating‐metallic transition, triggered by extraction/insertion of highly mobile Na+ ions upon application of an electric field. The memristor operates through a low‐energy process akin to Na+ shuttling in Na‐ion batteries rather than depending on formation/rupture of Ag filaments. Notably, it showcases promising characteristics, including non‐volatility, self‐compliance, and forming‐free behavior, and further exhibits low operation voltage (VSET = −0.26 V, VRESET = 0.36 V), low power consumption (PSET = 26 µW, PRESET = 8.0 µW), and a high ROFF/RON ratio of 104. This underscores the potential of high‐entropy insertion materials for developing printed memristors with distinct operation mechanisms.
Constructing 3D Crosslinked Macromolecular Networks as a Highly Efficient Interface Layer for Ultra‐Stable Zn Metal Anodes
Authors: Qu Yi‐Fan , Qian Jia‐Wei , Zhang Feng , Zhu Zibo , Zhu Yinbo , Hou Zhiguo , Meng Qiangqiang , Chen Kai , Dou Shi Xue , Chen Li‐Feng 
Published: November 2024

AbstractAqueous zinc ion batteries (AZIBs) are experiencing rapid development due to their high theoretical capacity, abundant zinc resources, and intrinsic safety. However, the progress of AZIBs is hindered by uncontrollable parasitic reactions and excessive dendrite growth, which compromise the durability and effective utilization of zinc metal anodes. To address these challenges, the study has constructed a 3D crosslinked macromolecular network composed of zinc ion‐bonded potato starch (StZ) as an interface layer on Zn foil (StZ‐Zn) to inhibit hydrogen evolution, regulate Zn2+ flux, and ensure uniform Zn deposition. Density functional theory calculations, molecular dynamics simulations, COMSOL Multiphysics simulations, and in situ Raman spectra demonstrate that the 3D StZ interface layer facilitates Zn2+ desolvation by restructuring the solvation shells. This process reduces the concentration of H2O at the anode, thereby inhibiting the hydrogen evolution reaction. Consequently, Zn2+ transport is more efficient, promoting a homogeneous Zn2+ flux and enabling dendrite‐free Zn deposition. As a result, StZ‐Zn||StZ‐Zn symmetric cell delivers a superb lifespan of 4800 h at the current density of 5 mA cm−2, and the corresponding cumulative capacity is as high as 12000 mAh cm−2. Notably, StZ‐Zn||NaV3O8·1.5H2O full cell can stably operate for 2500 cycles at 5 A g−1 with an outstanding capacity retention of 92%.
A Halted Photodeposition Technique Controls Co‐Catalyst Loading and Morphology on Organic Semiconductor Nanoparticles for Solar H2 Production
Authors: Firth Connor R. , Jeanguenat Colin , Lutz‐Bueno Viviane , Boureau Victor , Sivula Kevin 
Published: November 2024

AbstractSolar hydrogen production with semiconductor photocatalyst particles typically requires co‐catalysts, but since co‐catalysts are often deposited in situ, the rate of their nucleation/growth and role in parasitic light absorption are not well controlled. Herein a halted photodeposition‐dialysis method is introduced that affords unprecedented control over platinum (Pt) co‐catalyst loading and morphology on bulk heterojunction organic semiconductor photocatalyst nanoparticles. Pt loading and surface distribution are controlled by tuning the initial Pt precursor concentration and photodeposition time followed by removal of unreacted Pt precursor via dialysis. Applying this method with typical Pt deposition conditions gives a max H2 evolution rate of 140 mmol h−1 g−1 (based on semiconductor mass) with only 15.2 wt.% Pt deposited and suggests an optimum loading of <20 wt.% Pt, above which parasitic light absorption decreases the H2 evolution rate. Moreover, a peak H2 evolution >30 mmol h−1 g−1 is achieved with a Pt loading of only 1.01 wt.% by tuning the deposition conditions to favor a more uniform Pt coverage with small clusters and single atoms over larger Pt NPs. This represents a performance more than eight times higher compared to typical Pt photodepositions (based on Pt) and gives critical insights into optimizing performance.
An experimental study of pressure drop characteristics under single‐phase flow through packed bed microreactors
Authors: Zhang Lu , Hommes Arne , Schuring Remon , Yue Jun 
Published: November 2024

AbstractPacked bed microreactors offer a promising platform for intensifying heterogeneously catalyzed reactions. To understand hydrodynamics therein, N2 or water flow was investigated experimentally through microreactors packed with glass beads in this work, corresponding to a microreactor to particle diameter ratio (D/d) of 1.29–25.12. The porosity of a single pellet string microreactor (D/d < 1.866) agrees with the literature's theoretical equation. For microreactors with larger D/d ratios, an empirical porosity correlation is proposed to address the dense packing nature of the bed. The existing correlations are inadequate to describe the pressure drop data in microreactors within the entire D/d ratios and modified Reynolds numbers (Rem < 291). At D/d ≥ 3, the measured pressure drop is described by the modified Ergun equation using properties of the bulk bed zone to exclude the wall effect. At D/d < 3, it can be predicted by introducing a correction term for the wall effect into the Ergun equation.
Synthesis and Characterization of an Air‐Stable Tin(IV) β‐Tetracyanoisophlorin Complex: Enhanced Antiaromaticity through Metal Complexation.
Authors: Sugimura Haruna , Nakajima Kana , Yamashita Ken‐ichi 
Published: November 2024

AbstractIsophlorins, which are two‐electron reduced porphyrins, have garnered significant interest because of their potential antiaromaticity and unique electronic properties. However, the isolation of stable antiaromatic isophlorins remains challenging because they are prone to oxidation or reduction to the corresponding aromatic molecules, or are structurally distorted, resulting in loss of antiaromaticity. Here, we report the synthesis and characterization of a Sn(IV) β‐tetracyanoisophlorin complex obtained through two‐electron reduction of the corresponding Sn(IV) β‐tetracyanoporphyrin complex. This Sn(IV) complex exhibits enhanced antiaromaticity owing to its highly planar structure, facilitated by the central Sn atom. X‐ray crystal diffraction analysis revealed that the Sn(IV) isophlorin complex contains two methoxy groups as axial ligands and that it exists as a divalent anion, demonstrating the oxophilic nature of the Sn(IV) isophlorin complexes. Notably, this Sn(IV) isophlorin complex is stable under air, distinguishing it from previously reported Si(IV) and Ge(IV) isophlorin complexes without cyano groups. This study thus presents the first isolation of an air‐stable metal complex of antiaromatic isophlorin, opening new possibilities for exploring the unique properties of antiaromatic porphyrinoids for various applications, including catalysis and materials science.
How Carbene Ligands Transform AuAg Alloy Nanoclusters for Electrocatalytic Urea Synthesis
Authors: Zhang Jingjing , Zhang Yifei , Qin Zhaoxian , Li Zhiwen , Tong Zhaohui , Zhao Zhen , Gascón José A. , Li Gao 
Published: November 2024

AbstractMetal nanoclusters stabilized by N‐heterocyclic carbene (NHC) ligands have attracted increasing interest for their special structures and diverse applications. However, developing synthetic strategies and extending the database of NHC‐protected nanoclusters are still challenging tasks. In this work, a novel and rapid synthetic method is developed to prepare AuAg alloy nanocluster ligated by carbene based on the reactivity of nanoclusters. The rod‐like carbene‐capped bimetal nanocluster, [Au13Ag12(PPh3)8(BMIm)2I8]SbF6 (Au13Ag12 : BMIm), was achieved and characterized by a series of techniques. The alloy nanocluster consists of two vertex‐sharing icosahedrons and carbene ligands, phosphine ligands, and I atoms. Interestingly, the introduced carbene ligands show strong coordination capabilities with Au, enhancing the interaction between metal core and ligands. To the best of our knowledge, the carbene‐capped Au13Ag12 : BMIm nanocluster is the first of its kind to show higher thermostability and higher sensitivity to light compared with the homogeneously capped analogue nanocluster ([Au13Ag12(PPh3)10I8]SbF6). Density functional theory calculations attribute these properties to a unique delocalization of electrons within the frontier orbitals. Finally, the Au13Ag12 : BMIm anchored on NiFe‐LDH exhibits remarkable electrocatalytic activity in the electrosynthesis of urea from NO3− and CO2, achieving a urea production rate of 29.5 mmol gcat−1 h−1 with a Faradaic efficiency of 34 % at −0.5 V (vs. RHE).
Hexafluorophosphate‐Triggered Hydrogen Isotope Exchange (HIE) in Fluorinated Environments: A Platform for the Deuteration of Aromatic Compounds via Strong Bond Activation
Authors: Ni Yang , Lebelt Jonathan , Barp Milena , Kreuter Florian , Buttkus Hannah , Jin Jiaye , Kretzschmar Martin , Tonner‐Zech Ralf , Asmis Knut R. , Gulder Tanja 
Published: November 2024

AbstractThere is a perpetual need for efficient and mild methods to integrate deuterium atoms into carbon frameworks through late‐stage modifications. We have developed a simple and highly effective synthetic route for hydrogen isotope exchange (HIE) in aromatic compounds under ambient conditions. This method utilizes catalytic amounts of hexafluorophosphate (PF6−) in deuterated 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP‐d1) and D2O. Phenols, anilines, anisoles, and heterocyclic compounds were converted with high yields and excellent deuterium incorporations, which allows for the synthesis of a wide range of deuterated aromatic compounds. Spectroscopic and theoretical studies show that an interactive H‐bonding network triggered by HFIP‐d1 activates the typically inert P−F bond in PF6− for D2O addition. The thus in situ formed DPO2F2 then triggers HIE, offering a new way to deuterated building blocks, drugs, and natural‐product derivatives with high deuterium incorporation via the activation of strong bonds.