bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring Articulation Rate: A Comparison of Two Methods
Authors: Cosyns Marjan , Meulemans Myriam , Vermeulen Ellen , Busschots Lauranne , Corthals Paul , Van Borsel John 
Published: November 2018

Purpose
Mean articulatory rate (MAR) is an alternative approach to measure articulation rate and is defined as the mean of 5 rate measures in minimally 10 to maximally 20 consecutive syllables in perceptually fluent speech without pauses. This study examined the validity of this approach.

Method

Reading and spontaneous speech samples were collected from 80 typically fluent adults ranging in age between 20 and 59 years. After orthographic transcription, all samples were subjected to an articulation rate analysis first using the prevailing “global” method, which takes into account the entire speech sample and involves manipulation of the speech sample, and then again applying the MAR method. Paired-samples
t
tests were conducted to compare global measurements to MAR measurements.

Results

For both spontaneous speech and reading, a strong correlation was found between the 2 methods. However, for both speech tasks, the paired-samples
t
tests revealed a significant difference with MAR values being higher than the global method values.

Conclusions
The MAR method is a valid method to measure articulation rate. However, it cannot be used interchangeably with the prevailing global method. Further standardization of the MAR method is needed before general clinical use can be suggested.
Treating Speech Movement Hypokinesia in Parkinson's Disease: Does Movement Size Matter?
Authors: Kearney Elaine , Haworth Brandon , Scholl Jordan , Faloutsos Petros , Baljko Melanie , Yunusova Yana 
Published: November 2018

Purpose
This study evaluates the effects of a novel speech therapy program that uses a verbal cue and gamified augmented visual feedback regarding tongue movements to address articulatory hypokinesia during speech in individuals with Parkinson's disease (PD).

Method
Five participants with PD participated in an ABA single-subject design study. The treatment aimed to increase tongue movement size using a combination of a verbal cue and augmented visual feedback and was conducted in 10 45-min sessions over 5 weeks. The presence of visual feedback was manipulated during treatment. Articulatory working space of the tongue was the primary outcome measure and was examined during treatment and in cued and uncued sentences pre- and posttreatment. Changes in speech intelligibility in response to a verbal cue pre- and posttreatment were also examined.

Results
During treatment, 4/5 participants showed a beneficial effect of visual feedback on tongue articulatory working space. At the end of the treatment, they used larger tongue movements when cued, relative to their pretreatment performance. None of the participants, however, generalized the effect to the uncued sentences. Speech intelligibility of cued sentences was judged as superior posttreatment only in a single participant.

Conclusions
This study demonstrated that using an augmented visual feedback approach is beneficial, beyond a verbal cue alone, in addressing articulatory hypokinesia in individuals with PD. An optimal degree of articulatory expansion might, however, be required to elicit a speech intelligibility benefit.
Screening Children's Speech: The Impact of Imitated Elicitation and Word Position
Authors: McLeod Sharynne , Masso Sarah 
Published: November 2018

Purpose
Diagnostic decision making is influenced by the attributes of assessments. In order to propose time-efficient protocols for screening children's speech, this study aimed to determine whether eliciting imitated responses and analyzing productions in different word positions resulted in different levels of consonant accuracy.

Method

Participants were 267 English-speaking preschool-age children in the Sound Start Study whose parents were concerned about their speech. They were assessed using the International Speech Screener: Research Version (ISS;
McLeod, 2013
) using either imitated or spontaneous elicitation. Productions were compared with an established diagnostic assessment of speech accuracy (Diagnostic Evaluation of Articulation and Phonology;
Dodd, Hua, Crosbie, Holm, & Ozanne, 2002
).

Results

Participants' performance on the ISS was significantly correlated with performance on the Diagnostic Evaluation of Articulation and Phonology. Eliciting imitated productions on the ISS (
M
= 2:18 min,
SD
= 0:59 min) took significantly less time than spontaneous productions (
M
= 6:32 min,
SD
= 2:34 min). There was no significant difference in accuracy of imitated versus spontaneous productions in word-initial position; however, consonants were significantly less accurate in spontaneous than imitated productions in other word positions. Overall, participants had significantly lower consonant accuracy in word-initial position than within-word or word-final positions. Examination of the influence of word position on test discrimination, using receiver operating characteristic analyses, revealed acceptable test discrimination for percentage of consonants correct across word positions.

Conclusion
This research supports using imitated elicitation and analysis of percentage of consonants correct in word-initial position as a time-efficient procedure when screening the speech of English-speaking preschool children.
The VIMOS Public Extragalactic Redshift Survey (VIPERS)
Authors: Vergani D. , Garilli B. , Polletta M. , Franzetti P. , Scodeggio M. , Zamorani G. , Haines C. P. , Bolzonella M. , Guzzo L. , Granett B. R. , de la Torre S. , Abbas U. , Adami C. , Bottini D. , Cappi A. , Cucciati O. , Davidzon I. , De Lucia G. , Fritz A. , Gargiulo A. , Hawken A. J. , Iovino A. , Krywult J. , Le Brun V. , Le Fèvre O. , Maccagni D. , Małek K. , Marulli F. , Pollo A. , Tasca L. A. M. , Tojeiro R. , Zanichelli A. , Arnouts S. , Bel J. , Branchini E. , Coupon J. , Ilbert O. , Moutard T. , Moscardini L. 
Published: November 2018

Aims. We analyse the properties of the host galaxies of a [NeV]-selected sample to investigate whether and how they are affected by the AGN.
Methods. We have selected a sample of galaxies at 0.62 <  z <  1.2 from the VIMOS Public Extragalactic Redshift Survey (VIPERS) and divided it in blue cloud galaxies, red passive galaxies and green valley galaxies using the NUVrK diagram. Within each category, galaxies with AGN activity were identified based on the detection of the high-ionisation [NeV]λ3426 emission line. For each galaxy we derived several properties (stellar age and mass, the (r−K) colour, the [OII] luminosity) and compared them between active and inactive galaxies matched in stellar mass and redshift.
Results. We find statistically significant differences in the properties between active and inactive galaxies. These differences imply that the AGN is more often found in galaxies with younger stellar populations and more recent star-forming activity than their parent samples. Interestingly, the AGN identified through the [NeV]λ3426 emission line is not commonly found by traditional AGN-selection techniques based on shallow X-ray data, mid-IR colours, and classical line diagnostic diagrams, and might thus reveal a specific evolutionary phase. The spectral analysis reveals a sub-set of AGN within the blue cloud that has spectral signatures implying a sudden suppression of star formation activity similar to post-starburst galaxies.
Conclusion. Using the rich dataset of the large VIPERS sample we identify a novel class of active post-starburst galaxies that would be missed by traditional selection techniques. These galaxies belong to the blue cloud, but their star-formation activity has been recently suppressed, possibly by the AGN identified through the presence of the [NeV]λ3426 emission line in their spectra. Our results support the idea that AGN feedback may be responsible for halting star-formation in active blue galaxies and for their transition into the red sequence, at least in the 0.6–1.2 redshift range and for stellar masses greater than 5 × 1010 ℳ⊙. Our results are based on a complete spectroscopic sample and limited by the [NeV] observability, and the AGN can be variable and with a relatively short duty cycle. Considering this, AGN feedback that makes blue galaxies quickly transition to the red sequence may be even more common than previously believed.
The dependence of mass and environment on the secular processes of AGNs in terms of morphology, colour, and specific star-formation rate
Authors: Argudo-Fernández M. , Lacerna I. , Duarte Puertas S. 
Published: November 2018

Context. Galaxy mass and environment play a major role in the evolution of galaxies. In the transition from star-forming to quenched galaxies, active galactic nuclei (AGNs) also have a principal action therein. However, the connections between these three actors are still uncertain.
Aims. In this work we investigate the effects of stellar mass and the large-scale structure (LSS) environment on the fraction of optical nuclear activity in a population of isolated galaxies, where AGN would not be triggered by recent galaxy interactions or mergers.
Methods. As a continuation of a previous work, we focus on isolated galaxies to study the effect of stellar mass and the LSS in terms of morphology (early- and late-type), colour (red and blue), and specific star-formation rate (quenched and star-forming). To explore where AGN activity is affected by the LSS, we separate galaxies into two groups, of low- and high mass, respectively, and use the tidal strength parameter to quantify the effects.
Results. We found that AGN is strongly affected by stellar mass in “active” galaxies (namely late-type, blue, and star-forming), but that mass has no influence on “quiescent” galaxies (namely early-type, red, and quenched), at least for masses down to 1010 M⊙. In relation to the LSS, we found an increase in the fraction of star-forming nuclei galaxies with denser LSS in low-mass star-forming and red isolated galaxies. Regarding AGN, we find a clear increase in the fraction of AGNs with denser environment in quenched and red isolated galaxies, independently of the stellar mass.
Conclusions. Active galactic nuclei activity appears to be “mass triggered” in active isolated galaxies. This means that AGN activity is independent of the intrinsic properties of the galaxies, but is dependent on their stellar mass. On the other hand, AGN activity appears to be “environment triggered” in quiescent isolated galaxies, where the fraction of AGNs as a function of specific star formation rate and colour increases from void regions to denser LSS, independently of stellar mass.
Frühgeburtenrate in 6 Perinatalzentren in Baden-Württemberg – Potential zur Reduktion der Frühgeborenenzahl
Authors: Trotter Andreas , Schreiber Ricarda , Sander Silvia , Muche Rainer , Lucke Wolfram 
Published: November 2018

Zusammenfassung
Hintergrund Zur Qualitätssicherung der Versorgung Früh- und Reifgeborener wurden vom Gemeinsamen Bundesausschuss umfangreiche Struktur- und Personalvorgaben formuliert. Die Ergebnisqualität für das neonatale Outcome wird bereits seit langer Zeit erhoben. Obwohl Deutschland einer der höchsten Frühgeburtenraten in Europa aufweist, existieren bislang keine zentrumsspezifischen Daten zur Frühgeburtenrate.
Methoden An 6 Perinatalzentren Level 1 in Baden-Württemberg wurden über 2 Jahre alle Schwangeren erfasst, die mit einem Schwangerschaftsalter zwischen 22+0 und 31+6 Wochen in der Frauenklinik aufgenommen wurden (n=2972). Sofern sie innerhalb von 24 h nach Aufnahme mindestens eines der folgenden sekundären Einschlusskriterien 1. Gesicherte Amnionruptur, 2. Zervixlänge<25 mm oder 3. Tokogramm mit>3 Wehen von je mind. 30 sec. Dauer in 30 min erfüllten, wurde die Frühgeburtenrate vor 32+0 Schwangerschaftswochen bestimmt. Für 70,6% der Frühgeborenen konnte das neonatale Outcome erhoben werden.
Ergebnis Bei 21,1% (n=279) der Schwangeren, die mindestens ein sekundäres Einschlusskriterium erfüllten (n=1325), kam es vor 32+0 SSW zur Geburt von 344 Frühgeborenen. Die Frühgeburtenrate lag zwischen 16,8 und 27,9% (Differenz 11,1%). Eine niedrigere Frühgeburtenrate war nicht mit einem schlechteren neonatalen Outcome vergesellschaftet.
Schlussfolgerung Um die Ergebnisqualität eines Perinatalzentrums beurteilen zu können, sollte die Frühgeburtenrate als Qualitätsindikator Einzug finden. Eine Reduktion der Frühgeburtenrate um 5% könnte die Zahl der Frühgeborenen<1500 g Geburtsgewicht in Deutschland um 2400/Jahr (ca. 25%) reduzieren.
A Rare Case of Recurrence of Craniopharyngioma at Ectopic Site after Surgical Resection of Primary Tumor
Authors: Dey Subir , Rao Akhilesh , Sinha Shilpa , Kumar Sanjay ,   Nishant
Published: November 2018

AbstractEctopic recurrence of craniopharyngiomas after surgical resection of primary lesion is extremely rare. In this article, the authors describe a case of a 12-year-old girl with ectopic recurrence of craniopharyngioma in an extra-axial location in the right frontal region, after an attempt to completely resect the lesion originally located in the sellar region. The patient was investigated radiologically, hormonally, and histopathologic confirmation was sought. During surgery, it is important to take extra care in removing the primary lesion in toto. In case of cystic tumors, it is very important to aspirate cystic fluid completely, before resecting the capsule to avoid rupture or spillage. Long-term clinical and radiologic follow-up is suggested as ectopic recurrence may occur at a very late stage.
The Effects of a Standard Postoperative Rehabilitation Protocol for Arthroscopic Rotator Cuff Repair on Pain, Function, and Health Perception
Authors: Monesi Roberta , Benedetti Maria , Zati Alessandro , Vigna Daniela , Romanello Domenico , Monello Alberto , Rotini Roberto 
Published: November 2018

Purpose There is still conflicting evidence to support postoperative rehabilitation protocols using immobilization following rotator cuff repair over early motion. The objective of the study was to evaluate the evolution of pain, shoulder function, and patients' perception of their health status up to 1 year after cuff rotator repair and a standard postoperative rehabilitation protocol consisting of 4 weeks of immobilization followed by a 2-week assisted controlled rehabilitation.
Methods Descriptive, longitudinal, uncontrolled case-series study was performed on 49 patients who underwent arthroscopic rotator cuff repair following traumatic or degenerative lesions. VAS scale for pain, Constant–Murley score for function, and SF-12 score for quality of life were used as outcome measures and were administered before the rehabilitation treatment, at the end of the 2-week rehabilitation, 3 months, and 1 year after surgery.
Results VAS pain score decreased significantly along the follow-up reaching almost a nil value after 1 year (0.2). Function as measured by Constant–Murley score had a significant improvement during follow-up, reaching a mean value of 84.6. The short form (SF)-12 score increased over time reaching 46.3 for the physical and 43.8 for the psychological dimension, respectively, at 1 year.
Conclusion The present study confirmed an excellent outcome at 1 year after rotator cuff repair using a traditional 4-week immobilization followed by a 2-week rehabilitation protocol without evidence of tendon un-healing or re-tearing.
Level of Evidence This is a level IV, therapeutic case series.
Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification
Authors: Banerjee N. Sanjib , Moore Dianne W. , Broker Thomas R. , Chow Louise T. 
Published: November 2018

Significance
Persistent infection by the high-risk human papillomaviruses (HPVs) can lead to anogenital and head and neck cancers. The HPV vaccines effectively prevent new type-restricted infections but have no effect on preexisting infections. It is crucial to identify effective inhibitors of preneoplastic HPV infections. Histone deacetylases (HDACs) modulate chromatin structure and transcription, and are also essential for chromatin replication fork progression. Here we show that Vorinostat, a pan-HDAC inhibitor, stabilizes host cell tumor suppressors targeted by HPV oncoproteins E6 and E7 and abrogates productive infection by a high-risk HPV in organotypic cultures of human keratinocytes. Furthermore, Vorinostat selectively induces apoptosis in HPV-infected cells by decreasing DNA repair response while increasing the proapoptotic protein Bim. Vorinostat appears to be a promising therapeutic agent.
Deciphering the structure of the condensin protein complex
Authors: Krepel Dana , Cheng Ryan R. , Di Pierro Michele , Onuchic José N. 
Published: November 2018

Significance
SMC–kleisin protein complexes contribute to the structural maintenance of chromosomes and are essential for the functioning of cells across all domains of life. In particular, condensin is a ring-shaped motor complex responsible for chromosome segregation; however, key structural features of this complex remain controversial. Leveraging coevolutionary information, we are able to determine an atomically detailed structure of the whole condensin complex. Converging evidence indicates that the complex is composed of a single ring and undergoes large structural rearrangements to fulfill its function. Our findings constitute the first step toward studying the structure–function relationship of the various molecular motors operating on DNA.
On conductive argumentation
Authors: Moradi-Joz Rasool , Ketabi Saeed , Tavakoli Mansoor 
Published: November 2018

AbstractInspired by Aristotle and modern political theory,Fairclough and Fairclough (2012)introduce a model into Political Discourse Analysis (PDA) on the basis of deliberation and conductive argumentation (reasoning). This study makes an attempt to appraise the efficacy and adequacy of this model through examining Trump’s UN speech on Iran in 2017 in the light of other mainstream analytic tools and frameworks of Critical Discourse Analysis (CDA). The findings suggest that the model is a step toward including the cognitive interface in PDA, and that the premises adduced in Trump’s speech could serve the purpose of delegitimizing Iranian government and ‘Iranoregimephobia’, hence calling for confronting Iran. It is concluded that if integrated with other approaches, the model could serve to possibly counter-balance the subjectivity and skepticism associated with CDA-oriented studies, thus possibly proving itself as a practical, effective, and informative tool for the critical study of political discourse.
Discourse relations across genres and contexts
Authors: Fetzer Anita , Speyer Augustin 
Published: November 2018

Abstract
This paper presents an analysis of the linguistic realization of discourse relations across and within English and
German discourse, comparing the genres of newspaper editorial and personal narrative. It concentrates on Continuation, Narration
and Contrast, and Elaboration, Explanation and Comment. Particular attention is given to (1) their overt realization with textual
themes and pragmatic word order, and (2) the (non)adjacent positioning of discourse units realizing the relations. The
methodological framework is an integrated one, supplementing Systemic Functional Grammar with Segmented Discourse Representation
Theory. In the English and German narratives, there is a strong tendency to realize discourse relations overtly. The overall overt
realization is significantly higher for narratives in both languages with editorials being significantly less overt. There are
also significant differences in the overt realization of non-adjacently positioned units realizing discourse relations with
significant distributions in all cases, although the distribution in the narratives is less significant.
Effect of ultrasonication and Na2MoO4 content on properties of electroless Ni–Mo–P coatings
Authors: Jiang Jibo , Chen Haotian , Wang Yuhong , Zhu Liying , Sun Yaoxin , Lin Hualin , Han Sheng , Luo Yong , Qian Wei 
Published: November 2018

Electroless Ni–Mo–P composite coatings with or without ultrasonic field were successfully deposited. The Sodium molybdate concentration was changeable to receive various Mo and P contents. Compared with the absence of ultrasound field, the coatings obtained smoother surface and higher Mo and P contents. The microhardness was determined by Vickers diamond indentation. The results showed that the hardness improved with increasing molybdenum and phosphorus content. The sample revealed the optimum hardness (886 HV) as it possesses 8 wt-% of Mo and 14 wt-% of P. Furthermore, the coatings exhibited higher hardness under ultrasound field. The corrosion resistance was analysed by potentiodynamic polarisation. The results showed that the corrosion resistance was enhanced in the increase of molybdenum. The sample with the highest Mo content (10 wt-%) showed the best corrosion resistance (5.81 μA cm−2). In addition, the coatings with ultrasound field have an influence on improving the corrosion resistance of the coating.
Sika deer (Cervus nippon) velvet antler extract attenuates prostate cancer in xenograft model
Authors: Tang Yujiao , Fan Meiqi , Choi Young-Jin , Yu Yonghai , Yao Gang , Deng Yongyan , Moon Sang-Ho , Kim Eun-Kyung 
Published: November 2018

ABSTRACTThe present study determines whether antler extract (AE) possesses inhibitory effects in a prostate cancer (PC) xenograft model and explores the underlying mechanism. After therapeutic intervention for two weeks, AE significantly inhibited prostate cancer xenograft tumor growth by 65.08%, and prostate-specific antigen (PSA) and serum dihydrotestosterone (DHT) levels. However, AE increased the serum testosterone level compared to the vehicle control group. Furthermore, our investigation of the inhibitory effects on angiogenesis and epithelial-to-mesenchymal transition (EMT)-related genes revealed that AE downregulated matrix metalloproteinase 2 (MMP)-2, (MMP)-9, vascular endothelial growth factor (VEGF), zinc finger protein (SNAIL1), twist-related protein 1 (TWIST1), and zinc-finger E-box-binding homeobox 1 (ZEB1) in vivo. In contrast, AE increased tissue inhibitor of MMP (TIMP)-1, (TIMP)-2, and E-cadherin. The results suggest that AE possesses potent anti-PC activity, and this is the first report on the anti-PC effect of AE in vivo.
Effect of two different intensity distribution training programmes on aerobic and body composition variables in ultra‐endurance runners
Authors: Pérez Andrés , Ramos‐Campo Domingo J. , Freitas Tomás T. , Rubio‐Arias Jacobo Á. , Marín‐Cascales Elena , Alcaraz Pedro E. 
Published: November 2018

AbstractThe aim of this study was to compare the effects of two different intensity distribution training programmes (polarized (POL) and threshold (THR)) on aerobic performance, strength and body composition variables in ultra‐endurance runners. Twenty recreationally trained athletes were allocated to POL (n = 11; age: 40.6 ± 9.7 years; height: 175.4 ± 7 cm; weight: 73.5 ± 10.8 kg; fat mass 18.4 ± 6.0%; VO2max: 55.8 ± 4.9 ml/kg/min) or THR group (n = 9; age: 36.8 ± 9.2 years; height: 178.5 ± 4.2 cm; weight: 75.5 ± 10.4 kg; fat mass 14.9 ± 5.3%; VO2max: 57.1 ± 5.2 ml/kg/min) and performed the 12 weeks training programme. Both programmes had similar total time and load but a different intensity distribution (POL = 79.8 ± 2.1% in Zone 1; 3.9 ± 1.9% in Zone 2; 16.4 ± 1.5% in Zone 3; THR = 67.2 ± 4.6% in Zone 1; 33.8 ± 4.6% in Zone 2; 0% in Zone 3). Body composition, isokinetic strength and aerobic running performance were measured before and after each programme. Both groups decreased fat mass after training (POL= Δ–11.2%; p = .017; ES = 0.32; THR= Δ–18.8%; p < .01; ES = 0.48). Also, POL group improved running economy at 10 km/h (Δ–5.4%; p = 0.003; ES = 0.71) and 12 km/h (Δ–4.5%; p = .026; ES = 0.73) and running time to exhaustion (Δ2.4%; p = .011; ES = 0.33). No changes were observed in strength and no significant differences were observed between the group in any variable. Compared with THR distribution, 12 weeks of POL training efficiently improves aerobic performance in recreational ultra‐endurance runners.