bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of bromocriptine on left ventricular functional recovery in peripartum cardiomyopathy: insights from the BRO‐HF retrospective cohort study
Authors: Tremblay‐Gravel Maxime , Marquis‐Gravel Guillaume , Avram Robert , Desplantie Olivier , Ducharme Anique , Bibas Lior , Pacheco Christine , Couture Etienne , Simard François , Poulin Anthony , Malhamé Isabelle , Tran Dan , Rey Evelyne , Tournoux François , Harvey Luc , Sénéchal Mario , Bélisle Pierre , Descarries Laurence , Farand Paul , Pranno Nicolas , Diaz Ariel , Afilalo Jonathan , Ly Hung Q. , Fortier Annik , Jolicoeur Etienne Marc ,   on behalf of the BRO‐HF investigators
Published: December 2018

AbstractAimsBromocriptine is thought to facilitate left ventricular (LV) recovery in peripartum cardiomyopathy (PPCM) through inhibition of prolactin secretion. However, this potential therapeutic effect remains controversial and was incompletely studied in diverse populations.Methods and resultsConsecutive women with new‐onset PPCM (n = 76) between 1994 and 2015 in Quebec, Canada, were classified according to treatment (n = 8, 11%) vs. no treatment (n = 68, 89%) with bromocriptine. We assessed LV functional recovery at mid‐term (6 months) and long‐term (last follow‐up) and compared outcomes among groups. Women treated with bromocriptine experienced better mid‐term left ventricular ejection fraction (LVEF) recovery from 23 ± 10% at baseline to 55 ± 12% at 6 months, compared with a change from 30 ± 12% at baseline to 45 ± 13% at 6 months in women treated with standard medical therapy (P interaction < 0.01). At long‐term, a similar positive association was found with bromocriptine (9% greater LVEF variation, P interaction < 0.01). In linear regressions adjusted for obstetrical, clinical, echocardiographic, and pharmacological variables, treatment with bromocriptine was associated with a greater improvement in LVEF [β coefficient (standard error), 14.1 (4.4); P = 0.03]. However, there was no significant association between bromocriptine use and the combined occurrence of all‐cause death and heart failure events (hazard ratio, 1.18; 95% confidence interval, 0.15 to 9.31), using univariable Cox regressions based over a cumulative follow‐up period of 285 patient‐years.ConclusionsIn women newly diagnosed with PPCM, treatment with bromocriptine was independently associated with greater LV functional recovery.
An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing
Authors: Baumhoer Daniel , Amary Fernanda , Flanagan Adrienne M. 
Published: December 2018

AbstractThe last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p.K36M), mesenchymal chondrosarcoma (HEY1‐NCOA2), chondromyxoid fibroma (GRM1 rearrangements), aneurysmal bone cyst (USP6 rearrangements), osteoblastoma/osteoid osteoma (FOS/FOSB rearrangements), and synovial chondromatosis (FN1‐ACVR2A and ACVR2A‐FN1). All such alterations are mutually exclusive. Many of these have been translated into clinical service using immunohistochemistry or FISH. 60% of central chondrosarcoma is characterised by either isocitrate dehydrogenase (IDH) 1 or IDH2 mutations distinguishing them from other cartilaginous tumours. In contrast, recurrent alterations which are clinically helpful have not been found in high grade osteosarcoma. High throughput next generation sequencing has also proved valuable in identifying germ line alterations in a significant proportion of young patients with primary malignant bone tumors. These findings will play an increasing role in reaching a diagnosis and in patient management.
Heteroatom effects toward isomerization of intermediates in Wittig reactions of non‐stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton with benzaldehyde
Authors: Uchiyama Yosuke , Kuniya Suguru , Watanabe Ryo , Ohtsuki Takemaru 
Published: December 2018

AbstractIsomerization of intermediates, cis‐ and trans‐1,2‐oxaphosphetanes, in Wittig reactions of non‐stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton containing group 14 (PhSi, PhGe, PhSn, n‐BuSn) and 15 (P, As, Sb, and Bi) elements with benzaldehyde (PhCHO) was investigated by variable‐temperature (VT)31P{1H} NMR spectroscopy. The isomerization from the cis‐1,2‐oxaphosphetane to the trans‐form occurred at lower temperatures as the row number of the same group elements increases. Wittig reactions under the same conditions gave the (Z)‐olefin as a major product in the cases of period 3 elements (PhSi and P) and the (E)‐olefin as a major product in the cases of elements from period 4 and below (PhGe, PhSn, n‐BuSn, As, Sb, and Bi). The selectivity of olefin formation is considered to depend on the isomerization temperature of the intermediates, because each olefin must be obtained from the corresponding 1,2‐oxaphosphetane. The VT‐31P{1H} NMR spectra showed that the cis‐1,2‐oxaphosphetanes were the kinetic products in the first step of Wittig reactions and the trans‐forms were the thermodynamically stable products formed by isomerization from the cis‐forms via ring‐opening and ring‐closing reactions of phosphonium ylides with PhCHO. Density functional theory (DFT) calculations indicated that cis‐1,2‐oxaphosphetanes were less stable than the trans‐forms by ~2 kcal/mol, supporting thermodynamically favorable isomerization from cis‐forms to trans‐forms, as observed by VT‐31P{1H} NMR spectroscopy. Heteroatoms at the bridgehead position of the phosphaheteratriptycene skeleton significantly affected the isomerization temperature as well as the phosphorus‐31 signals in the 31P{1H} NMR spectra, which were observed at lower field as row number of the same group element increases.
Stigmatized‐Identity Cues and Consumer Applications Revisited
Authors: Sanchez Diana T. , Chaney Kimberly E. , Maimon Melanie R. 
Published: December 2018

This article responds to thoughtful commentaries provided by Lamberton (2019–this issue) and Wooten & Rank‐Christman (2019—this issue) on Chaney, Sanchez, & Maimon (2019—this issue), an article in which we discussed the implications of social psychological research on stigmatized‐identity safety cues for consumer behavior. In Chaney, et al. (2019–this issue), we contend that stigmatized‐identity cues can signal belonging to marginalized groups via the ideological assumptions made about companies. In this article, we first clarify our definition of stigmatized identities beyond the limitation assumed by Wooten & Rank‐Christman (2019—this issue). In addition, we join the conversation regarding when cues lead to divergent responses in social groups. We also consider how using identity cues can “backfire” and the importance of using marketing goals to assess the extent to which strategies using such cues succeeded. Lastly, we integrate Lamberton's (2019–this issue) framework of dignity architecture and related empirical findings to discuss some of the challenges of research on stigmatized‐identity cues.
Formation of a defect‐free polyimide/zeolitic imidazolate framework‐8 composite membrane for gas separation: in‐depth analysis of organic–inorganic compatibility
Authors: Tan Peng Chee , Ooi Boon Seng , Ahmad Abdul Latif , Low Siew Chun 
Published: December 2018

AbstractBACKGROUNDThe incompatibility between polymer matrix and filler usually leads to the formation of nonselective voids at the polymer/filler interface, which subsequently lowers the gas separation performance. In view of this, the effectiveness of (3‐aminopropyl)triethoxysilane (APTES) in promoting the interaction between alumina and polyimide (PI), as well as PI and zeolitic imidazolate framework‐8 (ZIF‐8) during the synthesis of PI/ZIF‐8 composite membrane was assessed experimentally. The experimental data also were verified through the calculation of binding energy via molecular simulation.RESULTSIt was found that APTES improved the adhesion between alumina‐PI and allowed the formation of a defect‐free alumina‐supported PI membrane up to five layers of PI dip‐coating. Similarly, the compatibility between PI–ZIF‐8 also was shown to be improved by APTES. Indeed, the optimum CO2 permeance and CO2/N2 selectivity were found at 93.47 GPU and 7.50, respectively, at five layers of ZIF‐8 dip‐coating. In this work, the polymer‐filler compatibility also was verified through molecular simulation whereby a lower binding energy was obtained for system incorporated with APTES.CONCLUSIONIn short, the results indicated that APTES was effective in stabilizing the PI/ZIF‐8 composite membrane. The polymer‐filler compatibility also was successfully evaluated through the simple molecular simulation approach without requiring time‐consuming experiments. © 2018 Society of Chemical Industry
Modeling audible detection of prairie grouse booming informs survey design
Authors: Holt R. Douglas , Butler Matthew J. 
Published: December 2018

ABSTRACTMany wildlife surveys, especially surveys of birds, are reliant upon audible detection of individuals. Many factors can affect call frequency and sound attenuation, which influence audible detection. Prairie grouse surveys are conducted during lekking and courtship (i.e., booming) to take advantage of frequent vocalization, resulting in greater detectability. Some researchers assume booming can be detected >1.6 km away. To test this assumption and determine factors affecting attenuation and detectability of booming, we established artificial lesser prairie‐chicken (Tympanuchus pallidicinctus) leks. We conducted sound detection trials at these leks using playback of recordings of male lesser prairie‐chickens calibrated to appropriate sound intensity. We modeled detectability using generalized linear mixed‐effects models with distance from lek and weather conditions as covariates. Our model suggested the odds of detecting lesser prairie‐chicken booming decreased 96.8% with each 1‐km increase in distance. Detectability decreased with increased wind speed and temperature, increased with relative humidity, and was influenced by wind direction. We use this model to predict probability of missing leks for line‐transects or point counts. For example, a survey of 1.6‐km‐wide transects during average weather (17.0°C and 60% relative humidity) with 12 km/hour winds would have a 25.6% (95% CI = 3.0–77.2%) to 77.6% (95% CI = 27.3–97.6%) chance, depending on wind direction, of detecting booming lesser prairie‐chickens within the surveyed strip. If point counts with a 0.8‐km radius were conducted under the same conditions, detectability would range from 17.7% (95% CI = 1.7–70.3%) to 70.3% (95% CI = 18.5–96.7%) depending on wind direction. To improve the overall chances of detecting lesser prairie‐chicken booming to ≥80%, surveys would have to be repeated 3 to 4 times. Our model describes the audibility of lesser prairie‐chicken booming and can be used to optimize tradeoffs among survey logistics (e.g., number of surveys needed, point spacing, wind speed thresholds) and detectability. © 2018 The Authors.Journal of Wildlife ManagementPublished by Wiley Periodicals, Inc. on behalf of The Wildlife Society.
Comparing the real and perceived cost of adenotonsillectomy using time‐driven activity‐based costing
Authors: Simmonds Jonathan C. , Hollis Russell J. , Tamberino Ruby K. , Vecchiotti Mark A. , Scott Andrew R. 
Published: December 2018

ObjectiveThis study aims to measure the costs of treating obstructive sleep apnea (OSA) in children with an adenotonsillectomy using time‐driven activity‐based costing (TDABC) and explore how this differs from cost estimates using traditional forms of hospital accounting.Study DesignProspective observational study.MethodsA total of 53 pediatric patients with symptoms of OSA or sleep‐related breathing disorder were followed from their initial appointment through surgery to their postoperative visit at an academic medical center. Personnel timing and overhead costs were calculated for TDABC analysis.ResultsTreating OSA with an adenotonsillectomy in a pediatric patient costs $1,192.61. On average, outpatient adenotonsillectomy costs $957.74 (80.31%); $412.18 of this cost ($4.89 per minute) was attributed to the overhead cost of the operating room. Traditional hospital accounting estimates outpatient adenotonsillectomy costs $2,987, with overhead attributing $11.27 per minute or $949.23 per case. 57% ($6.38 per minute) of the hospital's estimate for overhead was actually for equipment and implants used by different hospital services and not for equipment used in adenotonsillectomies.ConclusionThrough TDABC, we were able to highlight how traditional RVU‐based hospital accounting systems apportion all overhead costs, including items such as orthopedic implants, evenly across specialties, thus increasing the perceived cost of equipment‐light procedures such as adenotonsillectomies. We suspect that providers who perform a TDABC analysis at their home institution or practice will find their own unique insights, which will help them understand and control the different components of healthcare costs.Level of Evidence2Laryngoscope, 129:1347–1353, 2019
Lingual tonsil lymphatic tissue regrowth in patients undergoing transoral robotic surgery
Authors: Iannella Giannicola , Magliulo Giuseppe , Montevecchi Filippo , De Vito Andrea , Polimeni Antonella , De Vincentiis Marco , Meccariello Giuseppe , D'Agostino Giovanni , Gobbi Riccardo , Cammaroto Giovanni , Stomeo Francesco , Pang Kenny P. , Rotenberg Brian , Vicini Claudio 
Published: December 2018

Objectives/HypothesisTo evaluate a possible regrowth of lingual tonsil lymphatic tissue in patients submitted to lingual tonsil resection with transoral robotic surgery (TORS).Study DesignRetrospective Study.MethodsMedical records of patients surgically treated by means of TORS to remove excessive lymphatic tissue of the lingual tonsil were retrospectively reviewed. Postoperative endoscopic data after long‐term follow‐up were analyzed to investigate possible lymphatic tissue regrowth. Preoperative and postoperative lingual tonsil lymphatic tissue were classified according to the standardized Friedman's grading scale ranging from 0 to 4.ResultsSixty‐eight patients (41 male and 27 female; mean age = 51.3 years) were considered suitable for the study analysis. Clinical regrowth was observed in six (8.8%) patients: four (5.9%) and two (2.9%) patients with grade 2 and 3 lymphatic hypertrophy, respectively. No correlation between the grade of regrowth, the time interval from surgery, and the volume of lymphatic tissue removed was found.ConclusionsThe lymphatic tissue regrowth after TORS resection appears to be very low.Level of Evidence4 Laryngoscope, 129:2652–2657, 2019
Temporally Resolving Synchronous Degenerate and Nondegenerate Two‐Photon Absorption in 2D Semiconducting Monolayers
Authors: Cui Qiannan , Li Yuanyuan , Chang Jianhua , Zhao Hui , Xu Chunxiang 
Published: December 2018

AbstractDegenerate and nondegenerate two‐photon absorption (TPA) in WS2 and MoSe2 monolayers are synchronously induced and temporally resolved by femtosecond laser pump‐probe. Differential transmission signals in the first 500 fs consist of negative and positive components, that originate from direct probe depletion via nondegenerate TPA and carrier accumulation via degenerate TPA, respectively. Temporal cross‐correlation of pump and probe pulses allows us to fully decouple the ultrafast nondegenerate and degenerate TPA signals. Subsequently, degenerate and nondegenerate TPA coefficients are calculated as a function of pump irradiance. Under nonresonant pumping, 100 ± 10 and 250 ± 25 cm GW−1 are obtained for degenerate and nondegenerate TPA coefficients of monolayer WS2, respectively, which both present linearly decreasing trends as increasing pump irradiances. However, under resonant pumping of 2p excitonic states in monolayer MoSe2, degenerate TPA coefficients exponentially decrease from 800 to 80 cm GW−1 as increasing pump irradiances, due to the interplay between band‐renormalization and band‐filling effects, while nondegenerate TPA coefficient is about 650 ± 50 cm GW−1. For comparison, a trilayer MoSe2 is also investigated. These results set a foundation for precisely measuring TPA coefficients and actively controlling nonlinear excitonic dynamics via TPA in 2D semiconducting monolayers.
Self‐Healing Supramolecular Hydrogels for Tissue Engineering Applications
Authors: Saunders Laura , Ma Peter X. 
Published: December 2018

AbstractSelf‐healing supramolecular hydrogels have emerged as a novel class of biomaterials that combine hydrogels with supramolecular chemistry to develop highly functional biomaterials with advantages including native tissue mimicry, biocompatibility, and injectability. These properties are endowed by the reversibly cross‐linked polymer network of the hydrogel. These hydrogels have great potential for realizing yet to be clinically translated tissue engineering therapies. This review presents methods of self‐healing supramolecular hydrogel formation and their uses in tissue engineering as well as future perspectives.
Errata and addendum to “On the prime geodesic theorem for hyperbolic ‐manifolds” Math. Nachr. 291 (2018), no. 14–15, 2160–2167
Authors: Avdispahić Muharem 
Published: December 2018

AbstractWe correct the exponent in the error term of the prime geodesic theorem for hyperbolic 3‐manifolds and in Park's theorem for higher dimensions [, ].
Clinical application of chromosomal microarray analysis for the diagnosis of Williams–Beuren syndrome in Chinese Han patients
Authors: Xia Yu , Huang Shufang , Wu Yueheng , Yang Yongchao , Chen Shaoxian , Li Ping , Zhuang Jian 
Published: December 2018

AbstractBackgroundWilliams–Beuren syndrome (WBS; OMIM #194,050) is a rare multisystem disorder of a variable phenotypic spectrum caused by a heterozygous microdeletion in the WBS chromosome region (WBSCR) in 7q11.23.MethodsWe screened 38 Chinese Han patients with suspected WBS using chromosomal microarray analysis (CMA).ResultsPathogenic CNVs were identified in 34 of the patients, including 29 cases with a typical 7q11.23 microdeletion, three cases with atypical copy number variations (CNVs) within the WBS chromosome region and two cases with CNVs associated with other known syndromes. All 29 WBS patients with a typical microdeletion exhibited distinctive facial dysmorphisms and developmental delay. We observed that the incidence of pulmonary abnormalities was slightly higher than that of aortic abnormalities. We also found long philtrum and prominent lips with a thick lip that may warrant suspicion of WBS in the Chinese Han patients.ConclusionCMA facilitates diagnosis in individuals with classic/nonclassic features of WBS and demonstrated that when Chinese Han patients present with a less classical phenotype, such as pulmonary abnormalities, this may raise suspicion for a WBS diagnosis and suggest a referral for a genetics evaluation for a differential diagnosis.
LQ control of unknown discrete‐time linear systems—A novel approach and a comparison study
Authors: Li Nan , Kolmanovsky Ilya , Girard Anouck 
Published: December 2018

SummaryIn this paper, we propose a novel approach to the linear quadratic (LQ) optimal control of unknown discrete‐time linear systems. We first describe an iterative procedure for minimizing a partially unknown static function. The procedure is based on simultaneous updates in the estimation of unknown parameters and in the optimization of controllable inputs. We then use the procedure for control optimization in unknown discrete‐time dynamic systems—we consider applications to the finite‐horizon and the infinite‐horizon LQ control of linear systems in detail. To illustrate the approach, an example of the pitch attitude control of an aircraft is considered. We also compare our proposed approach to several other approaches to finite/infinite‐horizon LQ control problems with unknown dynamics from the literature, including extremum seeking and adaptive dynamic programming/reinforcement learning. Our proposed approach is competitive with these approaches in speed of convergence and in implementation and computational complexity.
A 4D feature‐tracking algorithm: A multidimensional view of cyclone systems
Authors: Lakkis Susan Gabriela , Canziani Pablo , Yuchechen Adrián , Rocamora Leandro , Caferri Agustin , Hodges Kevin , O'Neill Alan 
Published: December 2018

An objective four‐dimensional (4D) algorithm developed to track extratropical relative vorticity anomaly 3D structure over time is introduced and validated. The STACKER algorithm, structured with the TRACKER single‐level tracking algorithm as source of the single‐level raw tracks, objectively combines tracks from various levels to determine the 3D structure of the cyclone (or anticyclone) events throughout their life cycle. STACKER works progressively, beginning with two initial levels and then adding additional levels to the stack in a bottom‐up and/or top‐down approach. This allows an iterative stacking approach, adding one level at a time, resulting in an optimized 4D determination of relative vorticity anomaly events.A two‐stage validation process is carried out with the ECMWF reanalysis ERA‐Interim dataset for the 2015 austral winter. First the overall tracking capability during an austral winter, taking into account a set of climate indicators and their impacts on Southern Hemisphere circulation, was compared to previous climatologies, in order to verify the density and distribution of the cyclone events detected by STACKER. Results show the cyclone density distribution is in very good agreement with previous climatologies, after taking into account potential differences due to climate variability and different tracking methodologies. The second stage focuses on three different long‐lived events over the Southern Hemisphere during the winter of 2015, spanning seven different pressure levels. Both GOES satellite imagery, infrared and water vapour channels, and ERA‐Interim cloud cover products are used in order to validate the tracks obtained as well as the algorithm's capability and reliability. The observed 3D cyclone structures and their time evolution are consistent with current understanding of cyclone system development. Thus, the two‐stage validation confirms that the algorithm is suitable to track multilevel events, and can follow and analyse their 3D life cycle and develop full 3D climatologies and climate variability studies.
Genotype-by-environment interaction for seed quality traits in interspecific cross-derived Brassica lines using additive main effects and multiplicative interaction model
Authors: Bocianowski Jan , Niemann Janetta , Nowosad Kamila 
Published: December 2018

AbstractThe aim of this study was to assess genotype by environment interaction for seed quality traits in interspecific cross-derived Brassica lines by the additive main effects and multiplicative interaction (AMMI) model. The study comprised of 25 winter rapeseed genotypes i.e.: B. napus cultivar Californium, twenty three cross-derived Brassica lines and male sterile line of an F8 generation of B. napus (MS8), selected from resynthesized oilseed rape (B. rapa ssp. chinensis × B. oleracea var. gemmifera) using in vitro cultures of isolated embryos. Field trials were performed at three locations in 3 years in a randomized complete block design, with three replicates. AMMI analyses revealed significant genotype and environmental effects as well as genotype by environmental interaction with respect to all five observed traits. The lines 16 (B. napus line MS8 × B. rapa ssp. pekinensis) and 7 (B. napus line MS8 × B. carinata) are recommended for further inclusion in the breeding programs because their stability and good average values of observed traits, except total glucosinolates content for line 16 (the best total genotype selection indexes were equal to 81 and 97, respectively).