bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent Bleeding from the Iridocorneal Angle and Subsequent Ghost Cell Glaucoma Following Gonioscopy-Assisted Transluminal Trabeculotomy: A Case Report
Authors: Sozen-Delil Fatma Isil , Donmez Gun Raziye , Akçay Güzide , Kanar Hatice Selen , Şimşek Şaban 
Published: November 2024

Purpose:
This study aims to present a case involving intermittent bleeding from the iridocorneal angle following gonioscopy-assisted transluminal trabeculotomy (GATT) surgery, followed by the development of ghost cell glaucoma (GCG).

Methods:
A 25-year-old man with a history of post-traumatic angle recession glaucoma underwent uneventful 360° GATT surgery.

Results:
Two weeks after the surgery, while the reason for the incomplete resolution of hyphema remained unclear, intermittent bleeding from the iridocorneal angle and hemorrhage in the inferior vitreous were observed during the patient’s follow-up examination. Although bleeding was controlled with intravenous tranexamic acid therapy, the patient required pars plana vitrectomy due to the development of GCG. Despite medical treatment, the patient’s intraocular pressure (IOP) remained elevated during follow-ups, leading to the decision to perform Ahmed Glaucoma Valve implantation surgery as a final intervention. At the latest evaluation, the patient’s IOP was under control without medication.

Conclusion:
Following GATT surgery, the possibility of intermittent bleeding from the iridocorneal angle should be considered if the hyphema persists beyond the expected duration. Hospitalization and closer patient monitoring may be necessary to detect intermittent bleeding.
Erythema Multiforme
Authors: Bennett Copp Lauren 
Published: November 2024

ABSTRACT
Erythema multiforme is an acute, immune-mediated, mucocutaneous disorder that is frequently associated with herpes simplex virus. This condition is subdivided into two classifications: erythema multiforme minor and erythema multiforme major. It is important to recognize that erythema multiforme major is its own entity and should not be confused for Stevens–Johnson syndrome. This review will discuss the epidemiology, pathophysiology, diagnosis, and management of erythema multiforme so that dermatology nurses and providers are better able to identify and manage this disease.
Pachydermodactyly Associated With Repetitive Body-Focused Behaviors in an Adolescent Male
Authors: Patrick Bailey , Casterline Benjamin Warren , Braudis Kara , Martin Kari 
Published: November 2024

ABSTRACT
An 18-year-old male presented to outpatient orthopedics with asymptomatic, slowly progressive swelling of his fingers over the course of 2 weeks. Radiographs were unremarkable, which prompted a referral to dermatology. Examination revealed firm fusiform swelling of the proximal phalanges, sparing the thumb and interphalangeal joints. The overlying skin appeared normal. A skin biopsy was performed by the punch technique. Dermatopathology revealed excessive dermal mucin without fibrosis or inflammation to establish the diagnosis of pachydermodactyly, a disorder most common in adolescent males and associated with repetitive rubbing of the fingers or cracking of the knuckles. The patient's mother reported that he had a habit of cracking the finger joints. The patient was advised to discontinue this behavior; however, no improvement was reported on follow-up.
Development and Impact of a Cognitive Reserve Enhancement Program for Climacteric Korean Women
Authors: KIM Ji Hyun , PARK Seungmi 
Published: November 2024

ABSTRACT

Background
In light of the rising incidence of mild cognitive impairment in women, an appropriate cognitive reserve enhancement program is urgently needed for women experiencing climacteric symptoms.

Purpose
The purpose of this study was to develop a cognitive reserve enhancement program for climacteric women based on cognitive reserve theory (CRT) and to verify its effectiveness.

Methods
A nonequivalence control group, pre- and post-quasi-experimental design was used. The 58 climacteric women with subjective memory deterioration enrolled as participants were divided into the experimental group (28 women), which received a 24-session CRT-based cognitive reserve enhance program, and the control group (30 women), the members of which received the cognitive training via a mobile application after completion of the study. Valid data from 24 experimental and 26 control participants were available for analysis. Objective cognitive functions, including overall cognitive, memory, attention, and language, were measured pretest and posttest using the following tools: Everyday Cognition Scale (subjective cognitive function), Center for Epidemiologic Studies Depression Scale (depression), and World Health Organization Quality of Life-Brief Version (quality of life).

Results
The experimental group showed a statistically significant increase in overall cognitive function (t = 3.82, p = .001), memory (t = 2.63, p = .012), attention: number of correct answers (t = 2.12, p = .040), language high-frequency response speed (Z = −2.49, p = .013), and language low-frequency response speed (Z = −2.77, p = .006) in objective cognitive function after 8 weeks in comparison to the control group.

Conclusions/Implications for Practice
The intervention program tested in this study to enhance cognitive reserve in climacteric women includes cognitive training, emotional and social support, and group physical activity components was found to be effective in enhancing cognitive function.
Endocervical Brush Cytology After Cervical Conization as a Predictor of Treatment Failure: A Prospective Cohort Study
Authors: Carreras-Dieguez Núria , Torras Ines , Martí Cristina , Matas Isabel , Glickman Ariel , Fusté Pere , Mula Cristina , Alos Silvia , Hoya Sandra , Rakislova Natalia , Saco Adela , Marimon Lorena , Ordi Jaume , Torné Aureli , del Pino Marta 
Published: November 2024

Objective
Endocervical curettage (ECC) is the gold standard for predicting the persistence of high-grade squamous intraepithelial lesions (HSIL) after cervical conization. However, ECC has a high rate of unsatisfactory samples and may be uncomfortable for women. Endocervical sampling with brush (ECB) has been proposed as an alternative to ECC, which, in addition to the cytological evaluation, allows performing HPV testing using the same sample. We compared ECC and ECB performed immediately after conization to identify women with persistent HSIL.

Materials and Methods
This is a prospective single-center study, including 518 patients who underwent conization over a 10-year period (2012–2021). Immediately after treatment conization, we performed ECB sampling followed by ECC to all patients. We evaluated the accuracy of the 2 techniques for diagnosing persistent HSIL during follow-up.

Results
Persistent HSIL was identified in 8.9% of women. Eighteen percent of the ECC samples and only 7% of ECB cytology were unsatisfactory (p < .001). The accuracy of detecting persistent HSIL was similar for ECB and ECC (89.0%, 95% CI = 85.9–91.5 vs 90.8%, 95% CI = 87.7–93.2; p = .797). Adding HPV testing to ECB cytological evaluation increased the accuracy to 91.5% (95% CI = 88.8–93.6).

Conclusions
ECB can be reliably used to identify women with persistent HSIL after conization, as its accuracy is similar to ECC, with a lower rate of unsatisfactory results. The technique allows adding HPV testing to cytological evaluation, improving the accuracy of the test.
A Nomogram for Predicting the Transition From Recurrent Acute Pancreatitis to Chronic Pancreatitis
Authors: Wei Wanzhen , Ma Yifei , Zeng Jiahui , Song Yiqun , Han Yimin , Qian Weikun , Yang Xue , Wu Zheng , Ma Zhenhua , Wang Zheng , Duan Wanxing 
Published: November 2024

Objectives
Acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis are recognized as a continuum of pancreatic diseases. Recurrence increases the risk of progression to chronic pancreatitis. The aim of this study was to search for clinical features that may promote the progression of chronic pancreatitis in patients with recurrent acute pancreatitis

Materials and Methods
We retrospectively reviewed patients with recurrent acute pancreatitis from Medical Information Mart for Intensive Care-IV database. They were divided into a training cohort and a validation cohort. A nomogram was constructed based on clinical features during the second hospitalization. The discrimination and calibration of the nomogram were evaluated using the concordance index, area under the time-dependent receiver operating characteristic curve, and calibration plots.

Results
A total of 432 recurrent acute pancreatitis patients were evaluated, of which 93 (21.53%) were diagnosed with chronic pancreatitis later. Age, biliary pancreatitis, admission interval, alcohol dependence, lipase, and platelet were selected. The concordance index was 0.717 (95% confidence interval: 0.691–0.743) for the training cohort and 0.718 (95% confidence interval: 0.662–0.774) for the validation cohort. The area under the time-dependent receiver operating characteristic curve was >0.7 over 1000 days.

Conclusions
A nomogram was developed and validated to evaluate the transition from recurrent acute pancreatitis to chronic pancreatitis.
GATA6 amplification is associated with improved survival in TP53-mutated unresectable pancreatic cancer
Authors: Zhou Edward , Yang Jung-In , Habowski Amber N , Deschênes Astrid , Belleau Pascal , Ha Taehoon , Tzanavaris Chris J. , Boyd Jeff , Hollweg Christopher A. , Zhu Xinhua , Tuveson David A. , King Daniel A. 
Published: November 2024

Abstract

Objectives:

GATA6 expression has been recently recognized as a favorable prognostic marker of pancreatic cancer whereas TP53 is recognized as a poor prognostic marker. We evaluated treatment outcomes by genetic alterations in TP53 and GATA6 to determine the prognostic and predictive impact of co-alterations.

Methods
A single institution retrospective analysis was performed on patients diagnosed with PDAC between 2014 to 2023. TP53 genotype and GATA6 amplification status were included in an analysis of overall survival (OS) and progression free survival (PFS). Previously published patient-derived organoids were used to investigate correlation between genetic status and drug sensitivity.

Results
Patients with TP53 mutations had worse OS compared to the wild type TP53 population. In general, patients with GATA6 amplification had better OS and a trend towards better PFS than the non-amplified population. Among patients with a TP53 mutation, patients with GATA6 co-alteration had longer OS compared to those who were not GATA6 amplified. In contrast, among patients who were TP53 wild type, the presence or absence of a GATA6 amplification did not impact OS or PFS. GATA6 genotype was not associated chemotherapy drug response in an organoid pharmacotyping model.

Conclusions
We found that GATA6 amplification appeared to attenuate poor prognosis observed in TP53-mutant patients regardless of the type of standard chemotherapy received, suggesting the GATA6 amplification is a prognostic biomarker but not a predictive biomarker of standard-of-care chemotherapy.
Clinical effectiveness of a standardized community-based supervised post-acute rehabilitation model after total knee arthropathy: A pilot study
Authors: Tay Matthew Rong Jie , Neoh Eng Chuan , Wong Jiayen , Tan Xee Vern , Lim Chien Joo , Tan Kelvin Guoping 
Published: November 2024

Background:
Hospital-based outpatient physiotherapy is the standard of care for subacute rehabilitation after total knee arthroplasty (TKA) in Singapore. This study explores the clinical effectiveness of a standardized rehabilitation model at community-based rehabilitation centers to align the appropriate utilization of tertiary and community rehabilitative resources.

Methods:
In this pilot study, patients who had undergone TKA were assigned to either control group (n=30) or to intervention group (n=29). The control group received usual hospital-based outpatient physiotherapy, while the intervention group received rehabilitation at a community-based rehabilitation center based on standardized institution protocol. Primary and secondary outcomes were assessed at baseline and at 3 months post TKA.

Results:
Baseline characteristics in both groups were not significantly different. All patients completed the study. At 3 months, there were no significant differences in the Time Up and Go test (P<0.853), median 30 s chair rise (P=0.347), knee flexion passive range of motion (P=0.933), knee extension passive range of motion (P=0.409), and presence of knee extension lag (P=0.360). There was a lower pain intensity in the intervention group compared with the control group (P=0.003).

Conclusions:
A community-based post-acute TKA rehabilitative model demonstrated improvements in functional outcomes, and reduced pain intensity in study participants, with these findings being similar to that of standard of care hospital-based outpatient physiotherapy. This model of care warrants further evaluation in larger clinical trials.
Effects of Inspiratory Muscle Training in Patients with COPD Exacerbations: A Randomized Controlled Trial
Authors: Huang Wei-Yu , Lee Chien-Tzu , Chien Jung-Yien , Hsu Miaoju , Wang Li-Ying 
Published: November 2024

Abstract

Objective
Pulmonary rehabilitation (PR) is considered for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the impact of adding inspiratory muscle training (IMT) to PR on inspiratory muscle function is underexplored. This study aimed to evaluate the effects of IMT in addition to PR on inspiratory muscle function, functional exercise capacity (FEC), and quality of life (QoL) in patients with AECOPD.

Design
16 patients with AECOPD and a maximal inspiratory pressure (PImax) < 80 cmH2O were randomized into the experimental (PR + IMT) or the control (PR + sham IMT) group for an eight-week intervention. Inspiratory muscle activation was measured using surface electromyography, FEC was examined by six-minute walk distance (6MWD), and QoL was assessed with COPD Assessment Test (CAT).

Results
The experimental group showed sustained and significant improvements in inspiratory muscle function, 6MWD, and QoL after intervention (all p < 0.05). The experimental group had higher PImax with less diaphragm activation (both p < 0.001) and more improvements in 6MWD and QoL after intervention (both p < 0.05).

Conclusions
Adding IMT to PR resulted in more improvements in inspiratory muscle function, FEC, and QoL for patients with AECOPD, suggesting IMT as a beneficial addition to PR.
Associations Between Partial Common Extensor Tendon Tears and Clinical-Ultrasonographic Findings in Patients with Lateral Epicondylitis
Authors: Songur Kadir , Gunduz Nihan Erdinc , Ellidokuz Hulya , Gulbahar Selmin , Dilek Banu 
Published: November 2024

Abstract

Objective
This study investigates the effect of partial common extensor tendon(CET) tears on demographic, clinical and ultrasound(US) parameters in patients with lateral epicondylitis(LE). The research aimed to provide a comprehensive understanding of how these US-detected partial tears, influence the clinical presentation and imaging findings associated with LE.

Design
Retrospective cross-sectional study. Records of 227 patients with LE met the inclusion-exclusion criteria were reviewed. The patient-rated tennis elbow evaluation(PRTEE) questionnaire was used as the primary outcome measure. Secondary outcome measures were visual analogue scale for pain, algometric measurements, hand grip strength, and US parameters(maximum tendon thickness measurements from the capitellar-radiocapitellar sides and presence of bone abnormalities).

Results
Partial CET tears detected using US were present in 22.7%(n = 54) of the patients. Patients with partial CET tears were older(50,31±9,22), had higher PRTEE scores(65,48±12,76), capitellar-radiocapitellar maximum tendon thickness measurements(0,60±0,80/0,60±0,72), and incidence of bone abnormalities(%40.7,n = 32)(p < .05). Logistic regression analysis identified age and PRTEE pain score as associative factors with partial CET tears. Capitellar-radiocapitellar maximum tendon thickness measurements greater than 0.55 cm were associated with an increased probability of partial CET tears.

Conclusion
US-detected partial CET tears may worsen the clinical and US parameters in patients with LE. Older age, higher PRTEE scores and higher maximum tendon thickness measurements were associated with partial CET tears.
Effects of Exercise on Pain and Disability after Lumbar Disc Herniation Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Jin Hyungsub , Kwon JangWon , Lee Jeongmin , Lee Dong Joon , Lee Dong Hoon , Jeon Justin Y. 
Published: November 2024

Abstract

Objective
To evaluate the effects of postoperative exercise on pain, disability, and quality of life (QoL) after lumbar disc herniation (LDH) surgery.

Design
We systematically searched the PubMed, EMBASE, Cochrane Library, and PEDro databases up to May 2024. Two reviewers independently selected and assessed relevant randomized controlled trials investigating the effectiveness of postoperative exercise after the surgical treatment of patients diagnosed with LDH on low back pain, disability, and QoL assessed using visual analog scale (VAS), Oswestry Disability Index (ODI), and 36-item short-form health survey (SF-36).

Results
Compared with the control group, the exercise intervention group had significantly lower VAS scores both in the short-term (effect: 95% confidence interval [CI] = −1.14 [−1.69, −0.58], I2 = 91.4%, n = 9 studies) and long-term follow-up (effect: 95% CI = −0.99 [−1.89, −0.08], I2 = 58.9%, n = 4 studies). The exercise intervention group also showed a significant reduction in ODI in the short-term follow-up (effect: 95% CI = −5.00 [−7.72, −2.29], I2 = 79.3, n = 7 studies), but not in the long-term follow-up (effect: 95% CI = −0.80 [−3.97, 2.38], I2 = 0.0%, n = 4 studies). Among the SF-36 factors, physical function, pain, general health, energy and vitality, and social function significantly improved in the exercise intervention group compared with the control group.

Conclusions
Exercise after LDH surgery was effective in reducing pain and disability and improving QoL.
Determination of the Surgical Landmarks for the Anterior and Middle Cranial Fossa in Dry Skulls With the Photography System, Cadavers and 3-Dimensional Computed Tomography
Authors: Polat Sema , Tunç Mahmut , Öksüzler Fatma Yasemin , Öksüzler Mahmut , Özşahin Esin , Göker Pinar 
Published: November 2024

The present paper was designed to analyze the dimensions of such important bony structures and surgical landmarks, which are used by many clinicians in many surgical interventions, in dry skull, cadaver, and healthy subjects on computed tomography (CT) images, and to determine whether there is a significant difference between these methods, and to obtain reference values from 3 different methods. Eight cadavers and 16 dry skulls and 100 three-dimensional (3D) CT images were studied. Necessary permissions for the study were obtained from Ethics Comittee. The 16 parameters were measured with an electronic digital caliper accurate 0.01 mm (LCD Digital Vernier Dial Microcaliper (INCA, DCLA-0605, 0.6–150 mm, USA). Also, the images obtained were transferred to the 3D Slicer (version 5.6.2) software program. Eight cadavers and 16 dry skulls of Turkish adults were unknown age and sex, whereas the mean age of females and males on CT images were 31.63±11.23 and 33.70±13.34 years, respectively. All values of the surgical landmarks for the anterior and middle cranial fossa obtained from cadavers, dry skulls, and 3D CT subjects (except length of lesser wing, anterior clinoid lengths for 2 sides, and width for right side) were statistically significant between 3 groups (P<0.05). This paper was conducted for the morphometric analysis of the specific regions of the anterior cranial fossa (ACF), and middle cranial fossa (MCF), which are used in neurosurgical procedures This detailed anatomic and radiologic reference values will be an extremely important source in the planning of both clinical and surgical approaches for neurosurgeon, anatomist, and radiologists.
Exploring the associations between screen time and sleep quality in adult residents of Ahmedabad: A cross-sectional study
Authors: Patel Bharat , Pandya Disha , Prajapati Bhadrawati , Doshi Omkumar 
Published: November 2024

AbstractBackground and rationaleSleep is essential for overall health, but many people experience disruptions in their sleep patterns due to busy schedules and technology use. This study aims to examine the impact of screen time on sleep quality, considering factors such as smoking, caffeine use, napping, physical activity, and stress levels.MethodologyWe enrolled 371 participants from Ahmedabad for a cross-sectional study. 278 participants were included after the screening. They completed a questionnaire covering demographics, screen time, covariates, stress using the PSS10 scale, and sleep quality using the PSQI scale. Data was analyzed using IBM SPSS Statistics 22 after entering it into MS Excel.ResultThis study examines the relationships between lifestyle factors and sleep quality among adults aged 18 to 40 in Ahmedabad. The findings suggest that increased screen time (r = 0.518, p < 0.001) and higher stress levels (r = 0.530, p < 0.001) are associated with lower sleep quality. Additionally, nap frequency and physical activity show significant associations with sleep ratings. However, no significant connections were found between caffeine use at night or smoking/tobacco usage and sleep quality.ConclusionThe Spearman correlation indicates a moderate correlation between screen time and sleep quality, as well as between stress and sleep quality. The chi-square test shows significant associations between screen time before bed, napping, and physical activity with sleep quality. However, there is no association between nighttime caffeine consumption or smoking/tobacco use and sleep quality.
HuBERT-ECG: a self-supervised foundation model for broad and scalable cardiac applications
Authors: Coppola Edoardo , Savardi Mattia , Massussi Mauro , Adamo Marianna , Metra Marco , Signoroni Alberto 
Published: November 2024

AbstractDeep learning models have shown remarkable performance in electrocardiogram (ECG) analysis, but their success has been constrained by the limited availability and size of ECG datasets, resulting in systems that are more task specialists than versatile generalists. In this work, we introduce HuBERT-ECG, a foundation ECG model pre-trained in a self-supervised manner on a large and diverse dataset of 9.1 million 12-lead ECGs encompassing 164 cardiovascular conditions. By simply adding an output layer, HuBERT-ECG can be fine-tuned for a wide array of downstream tasks, from diagnosing diseases to predicting future cardiovascular events. Across diverse real-world scenarios, HuBERT-ECG achieves AUROCs from 84.3% in low-data settings to 99% in large-scale setups. When trained to detect 164 overlapping conditions simultaneously, our model delivers AUROCs above 90% and 95% for 140 and 94 diseases, respectively. HuBERT-ECG also predicts death events within a 2-year follow-up with an AUROC of 93.4%. We release models and code.