bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxonomic review of the genus Johnius (Perciformes: Sciaenidae) from East Malaysian waters, with comments on newly recorded Johnius species
Authors: HANAFI NORHAFIZ , CHEN MENG-HSIEN , CHANG CHIH-WEI , CHAO NING LABBISH , SEAH YING GIAT 
Published: December 2024

In terms of sheer abundance, taxonomic diversity, and species richness, Malaysia has one of the most diverse Sciaenidae in the Indo-West Pacific. Up to ten valid species of the sciaenid fish genus Johnius (e.g., J. amblycephalus (Bleeker, 1855), J. belangerii (Cuvier, 1830), J. borneensis (Bleeker, 1850), J. carouna (Cuvier, 1830), J. coitor (Hamilton, 1822), J. heterolepis Bleeker, 1873, J. macrorhynus (Lal Mohan, 1976), J. plagiostoma (Bleeker, 1849), J. sasakii Hanafi et al., 2022 and J. weberi Hardenberg, 1936), and with additional newly recorded species as J. trewavasae Sasaki, 1992, have been recorded to occur in East Malaysia (Borneo Island) coastal waters. The newly recorded species is a close congener to J. heterolepis Sasaki, 1992 and can be well distinguished by several characters and molecular evidence. The goal of this study is to review the taxonomic status of Johnius species in East Malaysia, Borneo Island, by using a literature review, morphological inference and molecular characters. Principal Component Analysis (PCA) successfully discriminates based on second anal spine length and gill raker length within sampled specimens. A phylogenetic tree based on cytochrome oxidase subunit I (COI) showed intraspecific levels of genetic differentiation within Johnius of East Malaysia, which forms a monophyletic group. Moreover, the new record of Johnius trewavasae in East Malaysia represented that the distribution of the subtropical genus Johnius extended to the southernmost part of the tropical region.
Efficacy and Safety of Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor T-Cell for the Treatment of Relapsed and Refractory AL Amyloidosis
Authors: Lebel Eyal , Asherie Nathalie , Kfir-Erenfeld Shlomit , Grisariu Sigal , Avni Batia , Elias Shlomo , Assayag Miri , Dubnikov-Sharon Tali , Pick Marjorie , Alexander-Shani Rivka , Bessig Nomi , Herr Shlomit , Shehadeh Alaa , Ishtay Aseel , Pimienta Shelly , Vainstein Vladimir , Zimran Eran , Cohen Yael , Avivi Irit , Cohen Cyrille , Stepensky Polina , Gatt Moshe E. 
Published: December 2024

PURPOSE

The use of anti–B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CART) therapy for AL amyloidosis (AL) is limited owing to patient frailty. HBI0101 anti-BCMA CART was the first proof of concept for its applicability to AL. This report addresses the AL patient cohort treated to date within the phase Ia/Ib clinical trial (ClinicalTrials.gov identifier:
NCT04720313
).

METHODS

After lymphodepletion, most AL patients were infused with 800 × 10
6
CARTs.

RESULTS
Sixteen patients were treated, with a median of four previous lines of therapy (range, 3-10), 14/16 were triple class refractory, and 6/16 were refractory to belantamab. Most patients (13/16) had cardiac involvement, including five with MAYO stage IIIa/IIIb at study entry. Cytokine release syndrome was frequent (14/16) but mostly low grade (grade 3: 3/16, no grade 4/5). No neurologic toxicity or treatment-related deaths were observed. There were five grade 3 AL-related organ deteriorations resolved quickly with supportive care. The overall hematologic response rate was 15/16 (94%) and complete response (CR) was 12/16 (75%). Minimal residual disease negativity was achieved in 9/14 evaluable patients. Most patients (8/13 evaluable) achieved an objective organ response. Seven patients died during long-term follow-up, three while in CR/very good partial response, and the median overall survival was 10.1 months (95% CI, 5.8 to not reached).

CONCLUSION
This largest clinical trial of AL patients treated with anti-BCMA CART demonstrates acceptable and manageable toxicity in a highly frail and resistant population with remarkable efficacy, leading to fast organ responses. Among patients with baseline advanced cardiac disease, deaths in the first year were frequent, suggesting that this effective therapy should be considered earlier in the course of therapy. Anti-BCMA CART may become a powerful tool for improving organ function and survival in patients with AL.
Extended-release Hydrocortisone Formulations—Is There a Clinically Meaningful Benefit?
Authors: Steintorsdottir Sandra D , Øksnes Marianne , Jørgensen Anders P , Husebye Eystein S 
Published: December 2024

Abstract
Despite best practice replacement therapy with corticosteroids, patients with adrenal insufficiency report diminished quality of life and face increased mortality and morbidity. Conventional formulations of hydrocortisone have short half-lives (about 90 minutes) requiring multiple dosing during the day. Since 2011, extended-release hydrocortisone (ER-HC) formulations have been available enabling once-, sometimes twice-daily dosing. Most studies comparing ER-HC formulations with conventional hydrocortisone therapy report reduction in body weight, blood pressure and glucose levels, and improved quality of life. However, it is still unclear if the reported beneficiary effects are due to differences in cortisol exposure or alterations in pharmacokinetics. Here, we review studies comparing conventional and ER-HC treatment in adrenal insufficiency and discuss whether these novel formulations are safe and offer clinically significant benefits.
Out-of-frame Translation Rescues a Loss-of-function Variant in a Novel TBCE Phenotype
Authors: Sparber Peter , Ulas Evgeniia , Filatova Alexandra , Tatarskiy Eugene , Perelman Grigory , Makretskaya Nina , Nagaeva Elena , Kareva Maria , Frolova Elena , Kalinchenko Natalia , Tvorogova Anna V , Golyshev Sergey , Burakov Anton , Tabakov Vyacheslav , Lozier Ekaterina , Konovalov Fedor , Voinova Victoria , Tiulpakov Anatoly , Skoblov Mikhail 
Published: December 2024

Abstract

Context
Pathogenic variants in the TBCE gene, encoding tubulin-specific chaperone E crucial for tubulin folding, are linked to three severe neurodevelopmental disorders: Hypoparathyroidism-retardation-dysmorphism syndrome, Kenny-Caffey syndrome type 1, and progressive encephalopathy with amyotrophy and optic atrophy.

Objective
We identified patients with a novel, milder TBCE-associated phenotype and aimed to characterize it at the clinical and molecular levels.

Materials and Methods
We conducted splicing analysis using deep next-generation sequencing of RT-PCR products and detected TBCE through Western blotting. Translation efficiency was measured using a luciferase reporter assay. Overexpression experiments were performed in Hela cells with tubulin staining. Immunofluorescence analysis was used for Golgi complex assessment, while microtubule dynamics were studied post-nocodazole treatment. Electron microscopy facilitated ultrastructural studies.

Results
We report 7 patients with a novel, milder TBCE phenotype, presenting with amyotrophy, testicular failure, and mild intellectual disability, with or without short stature. All patients were homozygous or compound-heterozygous for the NM_003193.5:c.100 + 1G &gt; A variant, which causes a splicing alteration and early frameshift. However, we found that the mild phenotype arises due to translation from an alternative open reading frame, producing a partially functional protein. Dermal fibroblasts showed reduced Golgi compactness but normal microtubule dynamics. Electron microscopy revealed varying levels of acto-myosin degradation. The c.100 + 1G &gt; A variant was found to be 10 times more frequent in Slavic samples than in gnomAD, suggesting underdiagnosis of this phenotype.

Conclusion
This study uncovers complex molecular mechanisms contributing to the milder phenotype in patients with the c.100 + 1G &gt; A variant, providing insights into a new TBCE-related disorder.
Development and External Validation of a Combined Clinical–Radiomic Model for Predicting Insufficient Hypertrophy of the Future Liver Remnant following Portal Vein Embolization
Authors: Wang Qiang , Brismar Torkel B. , Björk Dennis , Baubeta Erik , Lindell Gert , Björnsson Bergthor , Sparrelid Ernesto 
Published: December 2024

Abstract

Objectives
This study aimed to develop and externally validate a model for predicting insufficient future liver remnant (FLR) hypertrophy after portal vein embolization (PVE) based on clinical factors and radiomics of pretreatment computed tomography (CT)

Patients and methods
Clinical information and CT scans of 241 consecutive patients from three Swedish centers were retrospectively collected. One center (120 patients) was applied for model development, and the other two (59 and 62 patients) as test cohorts. Logistic regression analysis was adopted for clinical model development. A FLR radiomics signature was constructed from the CT images using the support vector machine. A model combining clinical factors and FLR radiomics signature was developed. Area under the curve (AUC) was adopted for predictive performance evaluation

Results
Three independent clinical factors were identified for model construction: pretreatment standardized FLR (odds ratio (OR): 1.12, 95% confidence interval (CI): 1.04–1.20), alanine transaminase (ALT) level (OR: 0.98, 95% CI: 0.97–0.99), and PVE material (OR: 0.27, 95% CI: 0.08–0.87). This clinical model showed an AUC of 0.75, 0.71, and 0.68 in the three cohorts, respectively. A total of 833 radiomics features were extracted, and after feature dimension reduction, 16 features were selected for FLR radiomics signature construction. When adding it to the clinical model, the AUC of the combined model increased to 0.80, 0.76, and 0.72, respectively. However, the increase was not significant.

Conclusions
Pretreatment CT radiomics showed added value to the clinical model for predicting FLR hypertrophy following PVE. Although not reaching statistically significant, the evolving radiomics holds a potential to supplement traditional predictors of FLR hypertrophy.
Colonialidad territorial y turismo como estrategia de construcción de paz territorial: horizontes y desafíos en Colombia
Authors: Betancourt Santiago Milson 
Published: December 2024

Este artículo aborda la comprensión de conflictos y violencias desde la perspectiva de la colonialidad territorial como propuesta teórica. Se busca entender las raíces de la no paz persistente en el mundo a partir de una caracterización de la conflictividad territorial y colonialidad territorial. Además, se propone la paz territorial como estrategia de transformación y superación del desordenamiento territorial de la vida. Con esta reflexión, en la segunda parte del trabajo se analizan las posibilidades, límites y desafíos de las propuestas del turismo como una estrategia de construcción de paz territorial. Se profundiza en la conexión entre el turismo y elementos clave en la construcción de la paz territorial, como la sustentabilidad, la equidad y la participación activa de las comunidades locales. Este texto es importante para repensar los sentidos, horizontes y desafíos que tienen las políticas de turismo que se enmarcan en objetivos de paz, transformación social y ambiental, a fin de conseguir avanzar en sus fines. El trabajo se construye desde una revisión crítica de algunos conceptos relacionados con la forma de comprender las guerras/violencias/conflictos en el mundo y Colombia, teniendo en cuenta una perspectiva combinada de la ecología política, la geografía crítica y los estudios decoloniales, que se condensa en el concepto de colonialidad territorial. En la tercera parte, a partir de estas miradas teóricas se hace la revisión de tres ejes esenciales para la construcción de alternativas desde el turismo: la paz territorial, la equidad y la sustentabilidad.
Modeling Aerially Applied Sprays: Additional AGDISPpro Model Comparisons
Authors: Teske Milton E. , Whitehouse Glen R. 
Published: December 2024

HighlightsSummarizes the historical development of the AGDISP/AGDISPpro deposition model.Provides details implementing the modeling of crosswind effects on aircraft vortices.Examines model agreement for two datasets: in-wind and crosswind fixed-wing aircraft deposition and hovering/rotating UAV spot spraying deposition.Interprets CHARM model predictions for maximum UAV forward flight wake decay times.Abstract. This article describes recent AGDISPpro model comparisons, addressing the separate upwind-downwind decay of aircraft vortices because of crosswind effects, model comparisons with in-wind and crosswind field data and UAV spot spraying data, and model predictions of UAV forward flight wake decay times. These data comparisons extend AGDISPpro usage to additional agricultural spraying applications and to UAV model development beyond the agricultural spraying to which AGDISPpro was historically developed. Keywords: AGDISPpro, CHARM, Crosswind effects, Model comparisons, Spot spraying, UAV.
Service quality in decentralized community-based Covid-19 antigen rapid diagnostic testing programmes in the Federal Capital Territory, Nigeria
Authors: Udoh Ekerette , Okonkwo Osayamen , Omoregie Godpower , Ura-Akubo Victoria , Anosike Nnamdi , Folorunsho Joshua , Orakwelu Evelyn , Bimba John , Hatzold Karin , Corbett Elizabeth L. , Nightingale Emily , Dunkley Yasmin 
Published: December 2024

Introduction
Decentralized COVID-19 testing with antigen rapid diagnostic tests (Ag-RDT) is recommended by the Nigerian Centre for Disease Control for community-level services. These services have been provided in Primary Healthcare Centers, Community Pharmacies, and licensed “Patent Medicine Stores” that serve the least affluent communities. To support quality assurance, we applied an adapted version of SPI-RT (Stepwise Process for Improving the Quality of HIV Rapid and Recency Testing) to sites providing COVID-19-RDTs in Federal Capital Territory of Nigeria.

Methods
Between September 2022 and February 2023 community healthcare facilities (48 Community Pharmacies, 21 Patent Medicine Stores, 79 Primary Health Centers) were evaluated using Stepwise Process for Improving the Quality of SARS-CoV-2 Antigen Rapid Diagnostic Testing (SPI-RT) Checklist, tailored to the local implementation context. Evaluated domains included service quality, documents and records, personnel training and certification, safety, physical infrastructure, pre-testing phase, testing phase, and post-testing phase. Each facility received an overall score, expressed as a percentage indicating their performance level.

Results
41/79 (52%) of Primary Health Centers scored at least 90% for service quality, as did 19/48 (40%) of pharmacies, with only 1/21 (4.8%) Patent Medicine Store. Apart from personnel training and certification, Primary Health Centers scored highest across most domains of service quality, followed by Community Pharmacies. The lowest median score in any domain was in the Patent Medicine Stores on testing and safety at 60% for both post-testing phase and safety.

Conclusion
Primary Healthcare Centers and Community Pharmacies can provide quality decentralized testing for COVID-19. Patent Medicine Stores may need additional support including monitoring and quality improvement initiatives to ensure the provision of high-quality decentralized COVID-19 rapid testing services.
Recommendations for the metallographic preparation of crack-like defects in PBF-LB/M additively manufactured alloy 625 builds
Authors: Giller M. , Cagliyan E. , Fischer B. , Neidel A. 
Published: December 2024

Abstact
Crack-like defects were found in powder bed fusion-laser beam/metal additive manufacturing built gas turbine burner components. This was somewhat surprising, since the subject material, Alloy 625, is readily weldable. The original equipment manufacturer responsible for the print job had a good track record and excellent experience with this particular alloy. From the findings obtained in the metallographic investigation that is the subject of this contribution it can be concluded that i) the crack-like defects may not be liquation or solidification cracks as initially thought (both hot cracking phenomena), but possibly lack of fusion defects, ii) after a first preparation step, the defects were not detectable with light optical microscopy, even after etching with Kalling’s II reagent, iii) only after re-polishing using oxide particle suspension, or, alternatively, after reverse electrolytic etch with the anode and cathode swapped, using Kalling’s II reagent as electrolyte (Kalling’s II modified, a.k.a. Ätzen von Alloy 625 – Ätzlösung nach Boromir – Boromir’s etch), defects became detectable, and iv) only observation in the scanning electron microscope allowed characterization of the defects as lack of fusion rather than hot cracking.
Variasi Bahasa Indonesia-Korea (Indokor) sebagai Identitas Youtuber Korea Selatan
Authors: Nova Indah Fauziah , Musyayyab Imam , Fasa Faradila Awalia 
Published: December 2024

Bahasa tidak hanya memuat entitas linguistik, tetapi juga memuat fungsi sosial dan identitas suatu kelompok masyarakat. Oleh karena itu, cara berbicara seseorang cenderung dapat menjadi indikator dalam menentukan latar belakang sosialnya. Popularitas budaya Korea Selatan di Indonesia menyebabkan konten dari orang Korea Selatan banyak ditonton oleh masyarakat Indonesia. Youtuber asal Korea Selatan yang telah menguasai bahasa Indonesia kemudian aktif membuat beragam konten dengan sasaran penonton dari Indonesia. Latar belakang sosial yang berbeda tersebut menyebabkan penggunaan bahasa Indonesia warga Korea Selatan memunculkan variasi Indonesia-Korea (Indokor). Untuk itu, penelitian ini bertujuan: (1) untuk menganalisis fitur kebahasaan yang digunakan oleh youtuber asal Korea Selatan; (2) untuk mendeskripsikan kecenderungan pola campur kode dan alih kode yang muncul dari youtuber asal Korea Selatan; dan (3) untuk mengkaji lebih dalam mengenai identitas youtuber Korea Selatan yang tecermin melalui penggunaan bahasanya. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif. Sumber data penelitian yaitu berupa video dari tiga youtuber asal Korea Selatan, yaitu Hari Jisun, Han Yoo Ra, dan Noona Rosa. Data artikel ini berupa tuturan yang diambil dari video ketiga youtuber tersebut. Teknik pengumpulan data menggunakan teknik simak dan catat. Hasil penelitian menunjukkan bahwa fitur kebahasaan yang digunakan oleh ketiga youtuber tersebut memiliki variasi dari aspek pengucapan/pelafalan, penguasaan kosakata, dan penggunaan tata bahasa. Kemudian, terdapat kecenderungan pola campur kode melalui pemilihan kata serapan dan istilah populer untuk memberikan efek dramatis. Kecenderungan pola alih kode tersebut disebabkan oleh perpindahan bahasa karena pengaruh audiens dan mitra tutur. Lebih lanjut, terdapat identitas yang terlihat pada youtuber Korea dalam penggunaan variasi Indokor, yaitu identitas kepribadian dalam penggunaan salam, identitas pembentuk konsep diri dan yang lain, dan identitas keinformalan.
Conociendo Corea a través de su historia
Authors: Rodriguez Gómez Camilo 
Published: December 2024

Uno de los procesos que han marcado al mundo durante los últimos tiempos ha sido sin duda alguna la globalización, la cual, mediante los lazos de interconectividad e interdependencia que ha generado entre naciones y pueblos de todo el mundo, han creado a su vez la necesidad de generar distintos métodos para el entendimiento y cooperación entre los miles de distintas culturas que hoy cohabitan.
En esta ocasión, impulsado por el X Encuentro de Estudios Coreanos en América Latina y por mi pasión para la historia, me he preguntado ¿Qué tan influyente ha sido la historia de Corea sobre su tan única y especial cultura?
Este documento busca hallar la respuesta a esta pregunta rememorando distintos periodos históricos transcurridos en la península coreana, comenzando con el asentamiento de los primeros pueblos y posterior fundación del reino de Gojoseon, así como el surgimiento y caída de los que le siguieron como fueron los reinos Goryeo y Joseon y su importancia en la rica cultural que hoy posee Corea.
Las numerosas guerras e invasiones soportadas durante siglos como las invasiones mongolas y japonesas en el siglo XIII y XVI, la colonización japonesa y finalmente a la olvidada guerra de Corea. Hechos que fortalecen la definición de identidad coreana dada al inicio del documento que les caracteriza como una nación fuerte en principios y tradiciones cuya ideología comunitaria les ha permitido sobrevivir al paso de los siglos.
Hombres de nieve: Las relaciones entre la República Popular Democrática de Corea y el Movimiento de Izquierda Revolucionaria de Chile (1965-1990). Estudio preliminar
Authors: Lanare Luciano 
Published: December 2024

El extendido y sinuoso camino de las relaciones de la República Popular Democrática de Corea (RPDC) con América Latina y el Caribe sigue siendo un tema rodeado de muy poca visibilidad. Solo en los últimos años, excelentes trabajos de investigación sobre las relaciones de la RPDC con los gobiernos de México, Argentina y Chile -durante la segunda parte del siglo XX- han echado un poco de claridad sobre esta apasionante trama. Sin embargo, aún queda por sacar de las penumbras, hechos y eventos que forman parte nodal de esta gran historia.
Cabe aclarar que, reconstruir este relato, se presenta muy dificultoso, aunque no imposible. Y resulta arduo, en primer lugar, por la gran dificultad que existe en consultar fuentes primarias, tanto en nuestra región como –principalmente- en la República Popular Democrática de Corea. En el primero de los casos, muchos de los actores que han participado en estos hechos han fallecido o siguen siendo reacios a divulgar momentos de su vida política que podrían resultar estigmatizantes. A pesar de los años trascurridos, todavía existe mucho resquemor al relato abierto sobre estas experiencias. En segundo lugar, la imposibilidad, tanto económica como del libre acceso a las fuentes norcoreanas condicionan –en parte- la reconstrucción de todo este enorme rompecabezas histórico. Por cuestiones que se deben a las condiciones generales en lo que se refiere a los trabajos en archivos o a la toma de testimonios directos en la RPDC, la complejidad para acceder desde América Latina, se torna una misión dantesca.
A lo anterior, se debe sumar también, lo complicado que resultará intentar reconstruir el sendero por el cual circularon estos canales de relaciones en cuanto se trató de contactos no oficiales e informales –muchas veces- sin registros oficiales ni descripciones públicas.
No obstante las salvedades expresadas, esta investigación, pueden gozar de futuro. Para ello se propone –dentro del gran campo de indagación que se intentará abarcar – abordar de uno de los casos más emblemáticos: El Movimiento de Izquierda Revolucionaria (MIR) de Chile y su conexión con Corea del Norte.
La hipótesis de trabajo, que aquí se propone entonces, se centrará en vislumbrar la posible existencia de lazos cercanos entre los militantes del Movimiento de Izquierda Revolucionaria (MIR) y la República Popular Democrática de Corea en la búsqueda de entrenamiento y asesoramiento militar entre la décadas de 1970 y 1980. En particular, trataremos de fundamentar dicha hipótesis –con eje central – en el llamado “Plan 78” dentro de la denominada “Operación Retorno” que inició sus actividades guerrilleras en julio de 1980 en la región sureña del Neltume (XIV Región de los Ríos, Chile).
De servitus nova (On the problem of legislative regulation of the subjectivity of artificial intelligence)
Authors: Gribanov D. V. , Belkanov E. A. 
Published: December 2024

The creation and successful operation of programs for electronic computers capable of performing actions not related to direct operator commands and not initially embedded in the programmable code (artificial intelligence class programs) have caused a number of problems in the theory of legal regulation, including including the problem of determining whether a program of the “artificial intelligence” class, performing independent actions of legal significance, acquires such properties as legal capacity and personality. The solution to this problem is possible through the use of the experience of Roman law.