bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geografia e Peregrinação / Geography and Pilgrimage
Authors: De Souza José Arilson Xavier 
Published: November 2018

Refletir acerca da relação entre geografia e peregrinação é a intenção deste artigo. Tal relação é investigada à luz das dimensões espaço-culturais que marcam a vida dos homens peregrinos. Com efeito, as peregrinações são compreendidas como processos de raízes geográfico-sociais que relacionam espaços, tempos e indivíduos e contextualizados mundos de significados, desvelando, assim, uma espécie de geografia das peregrinações. Ao focar na prática das peregrinações a pé, a noção de busca pelo espaço sagrado é ainda privilegiada nas reflexões impostas.Palavras-chave: Geografia; Peregrinação: Geografia das Peregrinações.AbstractTo reflect on the relationship between geography and pilgrimage is the intention of this article. The relation is investigated to the light of space-cultural dimensions that have been striking the life of pilgrim men. As an effect, the pilgrimages are understood as processes of geographical-social roots that relation spaces, times and individuals and several contextualized significances, exposing, like this, a kind of geography of pilgrimage. In focus in the pilgrimage practicals on foot, the notion of searching for the sacred space it is yet privileged in the imposed reflexions.Keywords: Geography; Pilgrimage; Geography of Pilgrimages.
Mobilidade espacial do trabalho: redundantes do Sertão de Alagoas como parte da reprodução do capital / Labor spatial mobility: superfluous of the hinterland of Alagoas as part of the reproduction of capital
Authors: Lima Lucas Gama , Silva Genilda Maria da , Feitoza Gleiton Do Nascimento 
Published: November 2018

O artigo tem como desiderato a investigação teórica/empírica sobre a mobilidade espacial do trabalho e sua manifestação particular no Sertão de Alagoas. Parte-se do pressuposto de que a mobilidade espacial do trabalho é um fenômeno imanente ao capitalismo e decorrente da expropriação dos trabalhadores de seus meios de produção, que formou uma massa de capital variável, redundante e móvel. O advento da acumulação flexível, no final década de 1960, galvanizou a mobilidade espacial do trabalho, em razão da transformação do desemprego em uma realidade inexorável. No Sertão de Alagoas, o latifúndio e o monopólio das fontes de água pelas oligarquias locais, a presença de camponeses, quilombolas e indígenas vivendo em minifúndios e a existência de trabalhadores privados do acesso ao emprego nos pequenos núcleos urbanos da região, ensejaram a formação de redundantes que, sazonalmente, deslocam-se para o Leste de Alagoas e para outras regiões do país. Parte dessa massa humana costuma ser capturada como trabalho escravo, sujeitando-se às formas mais vis de relações sociais. O Sertão de Alagoas se transformou num lócus espacial onde se formam e se evadem redundantes que acompanham os ciclos do capital.Palavras–chave: Mobilidade espacial; trabalhador redundante; acumulação flexível; reprodução do capital; trabalho escravo.Abstract The article has as desideratum the empiric/theoretical investigation about the labor spatial mobility and its particular demonstrations in the hinterland of Alagoas. A common assumption has been that labor spatial mobility is a specific phenomenon to capitalism and resulting of workers' expropriation and their production resources, that formed a variable, superfluous and mobile mass of capital. The advent of flexible accumulation, at the end of 1960, galvanized labor spatial mobility, on account of the unemployment transformation in an inexorable reality. In the hinterland of Alagoas, the latifundium and monopoly of water sources by local oligarchies, the presence of peasants, quilombolas and natives living in smallholdings and the presence of workers prevented from employment access within the region's small urban areas, brought the formation of superfluous workers that, seasonally, move to the East of Alagoas and to other regions of the country. Part of this human concentration tends to be captured as slave labor, which results in these people's objectification to the vilest forms of social relationships. The hinterland of Alagoas has transformed itself into a spatial locus where superfluous workers who follow the capital cycles are formed and migrate.Keywords: Spatial mobility; superfluous worker; flexible accumulation; reproduction of capital; slave labor.
Addressing Identity Tensions Through Paradoxical Thinking: Lessons from Artistic Interventions in Organizations1
Authors: Berthoin Antal Ariane , Debucquet Gervaise , Fremeaux Sandrine 
Published: November 2018

In organizational contexts characterized by multiple logics spanning from conformity to innovation, many employees experience tensions between a business-like identity and an artistic identity. The contribution uses data generated from Web-based surveys of employees, managers, and artists in 86 Spanish companies to explore how identity tensions can be addressed with paradoxical thinking. It shows that engaging in artistic interventions can help people accept and deal with identity tensions between self-and-other and between conformity-creativity in the workplace, enabling the removal of real or subjective barriers to generating new ways of collaborating, new ideas and new ways of doing things.
The Effect of Internal and External Lean Practices on Performance: A Firm-Centered Approach
Authors: Chanegrih Tarek , Creusier Jordane 
Published: November 2018

The aim of this paper is to enhance the understanding of the relationship between lean practices and both operational and financial performance. A sample of 171 French manufacturing firms shows a direct effect of external lean practices on financial performance. A firm-centered approach identified three profiles. “Full achievers” present significant differences in both operational and financial performance compare to “weak achievers”. Even if the difference in operational performance is significant between “full achievers” and “internal lean dominant”, there is not a significant difference in financial performance.
La Bibliothèque nationale du Québec, notre mémoire documentaire depuis vingt ans
Authors: Lassonde Jean-René 
Published: November 2018

La Bibliothèque nationale du Québec fête son vingtième anniversaire. L’auteur présente l’institution : historique; mandats; collections, édifices et services. Il décrit ensuite les ressources humaines et financières, ainsi que les activités de collaboration et de diffusion de la Bibliothèque.
Thésaurus : Personne handicapée, outil de coordination des services documentaires spécialisés
Authors: Janik Sophie 
Published: November 2018

Ce texte vise à présenter le Thésaurus : Personne handicapée qui vient d’être publié par l’Office des personnes handicapées du Québec (OPHQ). Ses 3 697 descripteurs avec leurs équivalents en anglais répartis en 95 schémas fléchés et environ 2 000 non-descripteurs précisent le langage spécialisé concernant les personnes handicapées et l’enfance en difficulté.
Le Thésaurus propose une terminologie qui correspond à la nouvelle conception de la situation des personnes handicapées, fruit d’une réflexion à laquelle a largement contribué l’OPHQ ces dernières années. Il se base également sur la classification de l’Organisation mondiale de la santé concernant les déficiences, incapacités et handicaps.
A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
Authors: Dhekne Herschel S , Yanatori Izumi , Gomez Rachel C , Tonelli Francesca , Diez Federico , Schüle Birgitt , Steger Martin , Alessi Dario R , Pfeffer Suzanne R 
Published: November 2018

Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRK2 R1441C mice. Rab10 phosphorylation strengthens its intrinsic ability to block ciliogenesis by enhancing binding to RILPL1. Importantly, the ability of LRRK2 to interfere with ciliogenesis requires both Rab10 and RILPL1 proteins. Pathogenic LRRK2 influences the ability of cells to respond to cilia-dependent, Hedgehog signaling as monitored by Gli1 transcriptional activation. Moreover, cholinergic neurons in the striatum of LRRK2 R1441C mice show decreased ciliation, which will decrease their ability to sense Sonic hedgehog in a neuro-protective circuit that supports dopaminergic neurons. These data reveal a molecular pathway for regulating cilia function that likely contributes to Parkinson’s disease-specific pathology.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
Academic Libraries and Librarians in the Disruptive Era
Authors: Liauw Toong Tjiek 
Published: November 2018

The past few decades have introduced us to the Digital Natives, a generation born in the 1980s, who have been familiar with Information and Communication Technology (ICT) and the myriads of ICT products since the day they were born. The last decade has also made us familiar with numerous disruptive innovations and technologies that have now been so pervasive in our daily lives and have ‘threatened’ many established practices on how we conduct our lives and businesses, such as ride-sharing (Uber, Grab, etc.), accommodation-sharing (AirBnb), and the blockchain technology that has been applied in more and more aspects of life, with Bitcoin as one of its applications in the crypto currency sector.

Those changes and disruptions have not spared the higher education (HE) sector. Nowadays HE institutions need to take into account the characteristics of the Digital Natives, and various disruptive innovations and technologies if they want to remain relevant and stay ahead of the competition in the sector. All aspects of HE – including academic libraries, are not immune to these changes and disruptions. In the past, academic libraries have tended to play their roles as the storehouse of information and the provider of space for individual learning. The advent of the Digital Natives and disruptive technologies have led some in the HE sector to argue that academic libraries would soon lose their relevance since nowadays information can be accessed digitally from anywhere and at any time. People who believe this line of thinking have given some examples. One of them is the demise of Blockbuster (movie rental) stores in the United States (US) with the emergence of online video/movie streaming services. However, many forget that libraries, including academic libraries, also have their social functions besides their traditional roles as an information storehouse and individual learning space. Due to their social functions, libraries have even been viewed as one of the most democratic spaces that societies have. This is especially true in the case of public libraries, but also – to some extent – true for academic libraries, where they also perform their functions as community hubs.
Highly Efficient In Vivo Targeting of the Pulmonary Endothelium Using Novel Modifications of Polyethylenimine: An Importance of Charge
Authors: Dunn Andrew W. , Kalinichenko Vladimir V. , Shi Donglu 
Published: November 2018

AbstractPulmonary vascular disease encompasses a wide range of serious afflictions with important clinical implications. There is critical need for the development of efficient, nonviral gene therapy delivery systems. Here, a promising avenue to overcome critical issues in efficient cell targeting within the lung via a uniquely designed nanosystem is reported. Polyplexes are created by functionalizing hyperbranched polyethylenimine (PEI) with biological fatty acids and carboxylate‐terminated poly(ethylene glycol) (PEG) through a one‐pot 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride/N‐hydroxysuccinimide reaction. Following intravenous injection, polyplexes show an exceptionally high specificity to the pulmonary microvascular endothelium, allowing for the successful delivery of stabilized enhanced green fluorescent protein (eGFP) expressing messenger ribonucleic acid (mRNA). It is further shown, quantitatively, that positive surface charge is the main mechanism behind such high targeting efficiency for these polyplexes. Live in vivo imaging, flow cytometry of single cell suspensions, and confocal microscopy are used to demonstrate that positive polyplexes are enriched in the lung tissue and disseminated in 85–90% of the alveolar capillary endothelium, whilst being sparse in large vessels. Charge modification, achieved through poly(acrylic acid) or heparin coating, drives a highly significant reduction in both targeting percentage and targeting strength, highlighting the importance of specific surface charge, derived from chemical formulation, for efficient targeting of the pulmonary microvascular endothelium.
Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine
Authors: Subbiah Ramesh , Guldberg Robert E. 
Published: November 2018

AbstractGrowth factors (GFs) are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key role in tissue regeneration, but one major limitation of GF‐based therapies is dosage‐related adverse effects. Additionally, the clinical applications and efficacy of GFs are significantly affected by the efficiency of delivery systems and other pharmacokinetic factors. Hence, it is crucial to design delivery systems that provide optimal activity, stability, and tunable delivery for GFs. Understanding the physicochemical properties of the GFs and the biomaterials utilized for the development of biomimetic GF delivery systems is critical for GF‐based regeneration. Many different delivery systems have been developed to achieve tunable delivery kinetics for single or multiple GFs. The identification of ideal biomaterials with tunable properties for spatiotemporal delivery of GFs is still challenging. This review characterizes the types, properties, and functions of GFs, the materials science of widely used biomaterials, and various GF loading strategies to comprehensively summarize the current delivery systems for tunable spatiotemporal delivery of GFs aimed for tissue regeneration applications. This review concludes by discussing fundamental design principles for GF delivery vehicles based on the interactive physicochemical properties of the proteins and biomaterials.
Recent Progress of Strong Exciton–Photon Coupling in Lead Halide Perovskites
Authors: Du Wenna , Zhang Shuai , Zhang Qing , Liu Xinfeng 
Published: November 2018

AbstractThe semiconductor exciton–polariton, arising from the strong coupling between excitons and confined cavity photon modes, is not only of fundamental importance in macroscopic quantum effects but also has wide application prospects in ultralow‐threshold polariton lasers, slowing‐light devices, and quantum light sources. Very recently, metallic halide perovskites have been considered as a great candidate for exciton–polariton devices owing to their low‐cost fabrication, large exciton oscillator strength, and binding energy. Herein, the latest progress in exciton–polaritons and polariton lasers of perovskites are reviewed. Polaritons in planar and nanowires Fabry–Pérot microcavities are discussed with particular reference to material and photophysics. Finally, a perspective on the remaining challenges in perovskite polaritons research is given.
Carbon Dioxide Hydrogenation and Formic Acid Dehydrogenation Catalyzed by Iridium Complexes Bearing Pyridyl‐pyrazole Ligands: Effect of an Electron‐donating Substituent on the Pyrazole Ring on the Catalytic Activity and Durability
Authors: Onishi Naoya , Kanega Ryoichi , Fujita Etsuko , Himeda Yuichiro 
Published: November 2018

AbstractCp*Ir (Cp*=pentamethylcyclopentadienyl) complexes with an N,N‐bidentate ligand such as 2,2′‐bipyridine serve as catalysts for both carbon dioxide (CO2) hydrogenation to formate and formic acid dehydrogenation in water. Previously, it was shown that the introduction of an electron‐donating substituent on 2,2′‐bipyridine is an effective method to improve the catalytic activity. Especially, the highly electron‐donating hydroxyl (OH) substituent performs much better than other substituents such as methyl or methoxy under basic conditions. However, the introduction of an OH substituent on the ligand has been limited to six‐membered rings such as pyridine or pyrimidine. These results prompted us to develop a new ligand comprising a pyridyl‐pyrazole with an OH group on the pyrazole moiety for Cp*Ir‐catalyzed CO2 hydrogenation and formic acid dehydrogenation. The resultant catalyst showed high catalytic activity in CO2 hydrogenation and excellent robustness in formic acid dehydrogenation with a turnover number of 10 million.magnified image
Cp*Co(III)‐Catalyzed C−H Alkenylation of Aromatic Ketones with Alkenes
Authors: Sk Md Raja , Bera Sourav Sekhar , Maji Modhu Sudan 
Published: November 2018

AbstractCost‐effective and air‐stable high‐valent cobalt(III)‐catalyzed weakly coordinating, ketone‐directed regioselective mono‐alkenylation of arenes and heteroarenes with alkenes is demonstrated. Various electron‐rich and electron‐deficient arenes are tolerated under the reaction conditions, providing E‐alkenylated products exclusively. The tert‐butyl‐acrylates serve as an acrylic acid surrogate to provide cinnamic acid derivatives via direct C−H alkenylation. A two‐step synthesis of a γ‐PPAR antagonist, the synthesis of indanone, and the modification of divinylsulfone are reported as applications. The mechanistic details suggest a base‐assisted intermolecular electrophilic substitution reaction pathway.magnified image
Synthesis of polyaluminum hydroxide on silica spheres for effective fire retardant
Authors: Kong Ha‐Sung , Kang Kwang‐Sun 
Published: November 2018

AbstractUntil recent years, the majority of flame retardants have been halogen‐containing compounds. Although halogen compounds slow down the flame spread and reduce the fire growth, they increase the release of toxic gases, such as CO and HX (hydrogen halide), are carcinogenic and toxic chemicals, and accumulate environment. The authors carried out the synthesis of polyaluminum hydroxide on silica spheres for effective fire retardant. Large surface area of nanosilica spheres was utilized for improve the fire retardancy. The surface of silica spheres was modified with 3‐mercaptopropyltrimethoxysilane (MPTMS) and polyaluminum hydroxide. The field emission scanning electron microscope images showed that the amount of aluminum hydroxide increased with increasing the amount of AlCl3. The characteristic absorption peaks of Al–OH, Si–OH, Si–O–Si, Si–O, –CH, Si–O–C, and Si–O–Al were observed. The existence of sulfur indicated the surface of silica spheres were modified with MPTMS. The small amount of Cl implied that most of the Al–Cl3 were hydrolyzed.
Short‐term clinical outcomes of laparoscopic gastrectomy for remnant gastric cancer: A single‐institution experience and systematic review of the literature
Authors: Otsuka Ryota , Hayashi Hideki , Sakata Haruhito , Uesato Masaya , Hayano Koichi , Murakami Kentaro , Kano Masayuki , Fujishiro Takeshi , Toyozumi Takeshi , Semba Yoshihide , Matsubara Hisahiro 
Published: November 2018

AbstractAimApplication of laparoscopic approaches for the treatment of remnant gastric cancers (RGC) is still controversial. Therefore, in the present study, the safety and effectiveness of laparoscopic gastrectomy (LG) for RGC was investigated.MethodsA total of 27 patients who underwent gastrectomy for RGC from June 2008 to September 2017 were enrolled in this study. A comprehensive review of the literature on LG for RGC published before December 2017 using the PubMed database was carried out.ResultsLaparoscopic gastrectomy was carried out in seven patients, and open gastrectomy (OG) was done in the remaining 20 patients. LG was associated with significantly less intraoperative blood loss (70 ± 71 vs. 1066 ± 1428 g; P < 0.001), significantly more retrieved lymph nodes (22 ± 13 vs. 12 ± 9; P = 0.03), a relatively lower postoperative complication rate, and a relatively shorter postoperative hospital stay than OG. A comprehensive review of the literature showed that LG for RGC was more likely to correlate with longer operative time, less blood loss, lower postoperative complication rate, shorter postoperative hospital stay, and more retrieved lymph nodes than OG.ConclusionThe clinical outcome of our patients with RGC and the literature indicated that a laparoscopic approach contributed to faster recovery after surgery than an open approach without sacrificing its radicality and was a safe and secure treatment option for RGC.
Prediction of Major Regio‐, Site‐, and Diastereoisomers in Diels–Alder Reactions by Using Machine‐Learning: The Importance of Physically Meaningful Descriptors
Authors: Beker Wiktor , Gajewska Ewa P. , Badowski Tomasz , Grzybowski Bartosz A. 
Published: November 2018

AbstractMachine learning can predict the major regio‐, site‐, and diastereoselective outcomes of Diels–Alder reactions better than standard quantum‐mechanical methods and with accuracies exceeding 90 % provided that i) the diene/dienophile substrates are represented by “physical‐organic” descriptors reflecting the electronic and steric characteristics of their substituents and ii) the positions of such substituents relative to the reaction core are encoded (“vectorized”) in an informative way.
CuI‐Mediated Bromoalkynylation and Hydroalkynylation Reactions of Unsymmetrical Benzynes: Complementary Modes of Addition
Authors: Xiao Xiao , Wang Tao , Xu Feng , Hoye Thomas R. 
Published: November 2018

AbstractBenzynes formed by heating a suitable triyne (or tetrayne) substrate are shown to react with in situ generated alkynyl copper species. The latter are compatible with the polyyne substrates and two types of chemistries have been achieved: (i) 1‐bromo‐1‐alkynes efficiently undergo net bromoalkynylation of the (unsymmetrical) benzynes and (ii) in situ generated alkynylcopper species give rise to hydroalkynylation products. The regiochemical preferences of these two modes of reaction are complementary to one another with respect to the position of alkynyl substituent in the final products.