bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD45RO-Positive Memory T-Cell Density in the Tumoral Core and Invasive Margin Predict Long-Term Survival in Esophageal Squamous Cell Carcinoma
Authors: Noma Toshiki , Makino Tomoki , Ohshima Kenji , Yamashita Kotaro , Saito Takuro , Tanaka Koji , Yamamoto Kazuyoshi , Takahashi Tsuyoshi , Kurokawa Yukinori , Nakajima Kiyokazu , Morii Eiichi , Eguchi Hidetoshi , Doki Yuichiro 
Published: December 2024

Abstract

Background
The association between tumor-infiltrating lymphocytes and tumor immunity has long been recognized. Among T-cell types, CD45RO-positive memory T cells (CD45RO+) are reported to correlate with survival in several cancer types, but clinical evidence is lacking in esophageal squamous cell carcinoma (ESCC).

Methods
In surgical specimens from 162 preoperatively untreated patients, immunohistochemistry for CD45RO was performed to evaluate the density of CD45RO+ in the tumor core (CT) and invasive margin (IM) using an auto-count method. Patients were classified into high- versus low-CD45RO+ groups based on CD45RO+ density in CT and IM separately and combined. The relationship between CD45RO+ density and clinicopathological factors, including prognosis, was evaluated.

Results
Average CD45RO+ density was 133/mm2 in CT and 372/mm2 in IM. No significant differences in clinicopathological factors according to high- versus low-CD45RO+ scores were identified. Using CT scores, the CD45RO+-high group had a better 5-year overall survival (OS) rate (77.2% vs. 54.7% CD45RO+-low, P = 0.0433), but OS rates did not differ statistically between the two groups by IM scores (75.7% vs. 50.3%, P = 0.0576). Using immunohistochemical scores for CT+IM, the survival difference was significant, with a 5-year OS rate of 73.7% for the CD45RO+-high group versus 46.3% for the CD45RO+-low group (P = 0.0141). Multivariate analysis identified CD45RO+ CT+IM density as an independent prognostic variable in OS (hazard ratio 2.27, 95% confidence interval 1.43-3.62, P = 0.0006).

Conclusions
Density of CD45RO+ expression in the CT and IM might be a predictor of long-term survival in ESCC.
Control postural estático y estabilidad del Core en deportistas de alto rendimiento
Authors: Villaquiran Hurtado Andres Felipe , Rivera Rujana Diana María , Portilla Dorado Enmanuel Fernando , Vernaza Pinzón Paola 
Published: December 2024

Objetivo: el propósito fundamental del presente estudio fue determinar la relación entre el control postural estático y la estabilidad del Core en deportistas de alto rendimiento del departamento del Cauca. Método: Estudio descriptivo, realizado a 20 deportistas de alto rendimiento con proyección a Juegos Deportivos Nacionales 2019, a los que se les realizó evaluación del control postural estático en tercera dimensión y valoración de la estabilidad del Core mediante registro electromiográfico de superficie. Resultados: Se encontró en los planos sagital y frontal presencia de cifosis por debajo de los 30° y curvaturas escolioticas por debajo de los 10°, al igual que asimetría en la alineación del calcáneo. Respecto al Core, se encontró un déficit en la estabilidad de la zona central, además se evidencio una relación estadísticamente significativa entre la estabilidad del core, la alineación de columna, la pelvis y el tobillo (p≤0,05) con alta magnitud de asociación. Conclusiones: La estabilidad del core está relacionada con el control postural estático en columna, pelvis y tobillo, evidenciando la necesidad de implementar programas preventivos para los deportistas que permitan cuidar su salud y disminuir la incidencia de lesión.
Hematoma espontáneo de pared abdominal asociado al uso de anticoagulantes orales de acción directa
Authors: Amado Garzon Sandra Brigitte , Ruiz Talero Paula Andrea , Serrano Maria Natalia 
Published: December 2024

Introducción: El hematoma espontáneo de la pared abdominal (HEPA) es un evento infrecuente y potencialmente fatal; Se describe la anticoagulación como el principal factor de riesgo, en especial con el uso de warfarina. Son pocos los casos reportados con el uso de anticoagulantes orales de acción directa (ACOD) y la mayoría reportan otro factor precipitante asociado. Se presenta un caso de HEPA asociado al uso de ACOD en quien no se identificó otro factor precipitante diferente a la anticoagulación.
Presentación del caso: Mujer de 74 años , consultó a un hospital de IV nivel en Bogotá por dolor abdominal y masa palpable de inicio súbito no asociada a trauma. Tenía antecedente de enfermedad tromboembólica venosa recurrente y venia anticoagulada con rivaroxabán. Al examen se palpaba masa dolorosa en flanco izquierdo, sin irritación peritoneal. Se realizó angiotomografía de vasos abdominales que mostro un hematoma del músculo recto abdominal izquierdo con sangrado activo de la arteria epigástrica inferior. No se encontraron otros factores relacionados diferentes a la anticoagulación como posible etiología. Se realizó embolización arterial selectiva con control del sangrado, lo que permitió el reinicio temprano de la anticoagulación.
Discusión: El HEPA es una entidad potencialmente fatal, se reporta la anticoagulación como el principal factor asociado, aunque, es un evento infrecuente con ACOD. La mayoría describen también factores desencadenantes como accesos de tos y vomito y requerirá un manejo expectante, sin embargo, se debe considerar el manejo endovascular temprano para mejores desenlaces.
Palabras clave: hematoma, pared abdominal, anticoagulantes, rivaroxabán, reporte de caso.
Unsilencing the Student Voice: Detecting and Addressing ChatGPT-Generated Texts Presented as Student-Authored Texts at a University Writing Centre
Authors: Coetzer Zonnike , Aardt Peet van 
Published: December 2024

Abstract
The convergence of ChatGPT and other artificial intelligence writing tools at tertiary learning institutions has raised concerns for lecturers and academic practitioners, particularly regarding the significant impact that overreliance on these tools can have on students’ development of critical thinking and academic integrity (Lo, 2023, p. 420). The greatest concern—according to the authors of this article—seems to be the possible loss of the student voice and academic opinion. This is because of the evident increase in students who submit AI-generated texts as their own (McDade, 2023). In the African context, where the critical voice of student scholars is extolled as one of the main spearheads for decolonialisation (Charles, 2019, p. 8), this erasure of the student voice through the overreliance on AI is particularly disconcerting. Therefore, the researchers propose and discuss strategies to be used in university classrooms and writing centres to determine if a text is AI-generated and to reinvite students to formulate their own academic opinions and, therefore, reclaim their own critical academic voice. In addition, techniques to promote fundamental learning skills that can be implemented by lecturers and writing centre consultants will be explored. Approaching the topic from the perspective of university writing centre practitioners, one of the research goals is to raise awareness of the characteristics and limitations of AI-generated texts to distinguish these writings from student-written texts. This will be done by juxtaposing examples of both—highlighting characteristics like (lack of) creativity, (un)reliability of citations, cohesion, sentence length and consistency. The text analyses will provide readers with relatable examples to assist them in identifying the lack of student voice. Finally, the researchers will explore how the merging of Critical Theory, socio-constructivism, and Socratic questioning techniques, as proposed by Argendien, Pillay, Dube and Masinga (2022, p. 69), can be implemented in the University of the Free State’s Writing Centre and Academic Literacy Unit, in order to encourage students who overly relied on AI to regain their agency as academic writers.
The bionomics of Anopheles arabiensis and Anopheles funestus inside local houses and their implications for vector control strategies in areas with high coverage of insecticide-treated nets in South-eastern Tanzania
Authors: Limwagu Alex J. , Msugupakulya Betwel J. , Ngowo Halfan S. , Mwalugelo Yohana A. , Kilalangongono Masoud S. , Samli Faraji A. , Abbasi Said K. , Okumu Fredros O. , Ngasala Billy E. , Lyimo Issa N. 
Published: December 2024

Background
Residual malaria transmissions in Africa may be associated with improved coverage of insecticide-treated nets, house features, and livestock husbandry. These human-land use activities may drive the ecology and behaviour of malaria vectors which sustain residual malaria transmission. This study was conducted to assess changes in the ecology and behaviour of Anopheles funestus and Anopheles arabiensis in villages with high coverage of insecticide-treated nets to guide the selection of complementary vector control strategies against residual malaria transmission.

Methods
Mosquitoes were collected using a CDC-light trap, miniaturized double net trap, and Prokopack aspirator from 222 households in three villages (Ebuyu, Chirombora, and Mzelezi) within Kilombero Valley. Anopheles mosquitoes were morphologically identified to their physiological status and species-complex levels. A sub-sample of Anopheles mosquitoes was exposed to laboratory analyses of sibling species, host preference, and sporozoite rates. Additionally, the local houses were geo-referenced using Global Positioning Systems (GPS) devise, and house features were recorded and associated with vector abundance.

Results
The population of An. funestus s.s was abundant with high Plasmodium sporozoite rates inside houses compared to An. arabiensis. However, these vector species equally blood-fed on humans inside houses, but they also flexibly mixed human and animal blood meal. Fewer An. funestus were caught in houses with metal- than grass roofs and houses with and without animals. Contrastingly, fewer An. arabiensis were caught from houses with screened eaves compared to houses with open eaves.

Conclusions
This study confirms that An. funestus dominates residual malaria transmission over An. arabiensis. These vector species exhibit anthropophily and opportunistic blood-feeding behaviour in areas with high coverage of insecticide-treated nets, but they numerically respond differently to local house improvements. These results imply that integrating mosquito-proof houses, improved insecticide-treated nets, and livestock-based interventions could effectively reduce and eventually eliminate residual malaria transmission.
Integrating physiotherapy into primary care models: A scoping review protocol
Authors: Saddy Nathaniel , Aboosally Aamir , Aslanidis Jordan , Beilin Anthony , da Silva Schezar Jessica , Miller Jordan , Tawiah Andrews K. 
Published: December 2024

Introduction
Physiotherapists (PTs) working in primary care settings within an interprofessional team can lead to favourable health outcomes and decreased burden on the healthcare system. Although PT models of care are important to primary care delivery, there is a lack of knowledge and evidence on the characteristics of these models of care, the differences and similarities between the models, and the barriers and facilitators to implementing these models. This scoping review protocol aims to fill this knowledge gap by synthesizing the evidence and characteristics of models of care that integrate physiotherapists within primary care teams, mapping the similarities and differences, and describing barriers and facilitators to implementing models of care that integrate physiotherapists within primary care teams.

Methods
The scoping review is based on the Joanne Briggs Institute (JBI) framework. It is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRIMSA-ScR). A comprehensive search strategy will be used to find relevant papers in six databases: OVID MEDLINE, PubMed, Embase, CINAHL, Web of Science, and Scopus. Grey literature will be searched through OpenGrey, Theses Global, ProQuest Dissertation, and Google Scholar. Quantitative and qualitative study designs will be included, with two reviewers independently selecting each article on Covidence. Data will be extracted using a pre-piloted data extraction sheet and synthesized narratively to identify themes and patterns.

Discussion
This scoping review will synthesize the evidence on models of care that integrate physiotherapists within primary care teams. It will provide evidence to inform the implementation of these models of care and identify research gaps that need to be addressed. The protocol is registered on Open Science Framework registries at https://osf.io/kh83r/.
The influence of rotational error and axial shift of toric intraocular lenses on residual astigmatism
Authors: Gargallo Diana , Remón Laura , Ares Jorge , Castro-Alonso Francisco J. 
Published: December 2024

Purpose
Accurate alignment of Toric Intraocular Lens (T-IOLs) in cataract surgery is crucial for good visual outcomes. The purpose of this study was to evaluate the influence of rotation, axial shift and their combined effects on the refractive error and image quality of a wide range of T-IOL powers (from +1.50 D to +6.00 D cylinder) and two pupil diameters (3.34 and 4.44 mm).

Methods
Numerical ray tracing was utilized to quantify the residual error. Simulated retinal images and Visual Strehl (VS) ratios were calculated to evaluate image quality.

Results
First, T-IOL rotation showed better agreement with Holladay’s formula than 3.33% rule. Second, axial displacement resulted in acceptable residual cylinder (<0.50 D) across all examined cylinder powers. Third, concerning the combined effects, the influence of axial shift on residual cylinder becomes negligible when rotation errors exceed 2.5°. Fourth, a pupil-dependent nonlinear relationship was noted for image quality caused by both types of misalignment factors.

Conclusions
The 3.33% rule was confirmed as a reasonable approximation for the residual astigmatism caused by rotation of T-IOLs. The influence of axial shift on residual astigmatism becomes insignificant when there is also rotation. Image quality studies confirm that 30° of rotation are enough invalidate the compensation benefits of a T-IOLs in comparison with a Spherical Intraocular lens.
Evaluation of design parameters on the outcome of intrastromal ring surgery using biomechanical simulations
Authors: Bahramizadeh-Sajadi Shima , Katoozian Hamid Reza , Ariza-Gracia Miguel Angel , Gholami Morteza , Baradaran-Rafii Alireza , Büchler Philippe 
Published: December 2024

Background
The cornea plays a role in the refractive power of the eye, and when its natural curvature and thickness are compromised by diseases such as keratoconus or high myopia, this results in loss of visual acuity. Intracorneal rings (ICRs) were developed as a treatment option to restore the natural corneal curvature by implanting rings into tunnels cut within the corneal stroma. However, selecting and placing the appropriate ring can be difficult, and predicting refractive outcomes is challenging.

Objective
The purpose of this study was to better understand the design parameters of the rings that determine postoperative refractive and mechanical outcomes.

Methods
We developed an automated finite element simulation pipeline for ICR implantation and tested 300 variations of 20 ICRs.

Results
The outcome of ICR was dominated by the vertical size of the ring; 84% of the change in corneal curvature can be attributed to the vertical size of the ring, while only 13% were attributed to the detailed cross-sectional shape of the ring. However, the cross-sectional shape of the ring is limited to the change in axial length and contact pressure between the ring and the cornea. The horizontal dimension of the ring plays only a minor role in the postoperative outcome.

Conclusion
These results support Keraring’s approach to ring scaling, in which only the vertical dimension of the ring is changed, while the horizontal dimension remains constant. Numerical models help to understand ICR outcomes, design implants, and personalize empirical nomograms to achieve more successful postoperative outcomes.
Spanish versión of The App Behavior Change Scale (ABACUS-Es): Adaptation and validation study
Authors: Martin-Payo Ruben , González-Nuevo-Vázquez Covadonga , Álvarez-Gómez Estela , Surendran Shelini , Cachero-Rodríguez Judit , Fernandez-Alvarez María del Mar 
Published: December 2024

Background
Health applications have grown exponentially in the last decade and are well accepted by users and health services. It is essential that digital tools meet the needs of the target users and are reliable, hence the importance of evaluating them. The aim of this study was to adapt The App Behavior Change Scale (ABACUS) into the Spanish language and to assess their metric properties.

Methods
This was an study undertaken in two phases: (1) translation and cultural adaptation process; (2) psychometric evaluation. 65 physical activity apps were included in the study (9 running Apple, 50 running Android and 6 running both). Cross-cultural adaptation, translation, and metric evaluation was made. The internal consistency and test-retest reliability of the Spanish version of the ABACUS was evaluated using physical activity apps. Two reviewers independently rated the apps using the translated scale. The apps were then rated again 2 weeks later by the same reviewers to measure test-retest reliability.

Results
No major differences were observed between both versions of ABACUS (original and Spanish). Discrimination indices (item-scale correlation) obtained appropriate results for both raters. ABACUS-Es presented an excellent interrater reliability (0.82, 95% CI 0.80–0.84) and excellent internal consistency (Cronbach alpha = 0.82).

Conclusions
The Spanish version of ABACUS, ABACUS-Es, is an instrument with adequate metric properties to measure the potential behavior change of apps from health professionals and app developers. ABACUS will help guide future research efforts in the development and evaluation of apps to promote health behaviors, and provides guidance for app developers to include adequate behavior change techniques in apps in Spanish to be used to promote health behaviors.
Barriers and facilitators of fetal heart monitoring with a mobile cardiotocograph (iCTG) device in underserved settings: An exploratory qualitative study from Tanzania
Authors: Mwakawanga Dorkasi L. , Chen Sanmei , Ogata Yhuko , Suzuki Minami , Kobayashi Yuryon , Toda Miyuki , Hirose Naoki , Shimpuku Yoko 
Published: December 2024

Background
Fetal monitoring in low-resource settings is often inadequate. A mobile cardiotocograph fetal monitoring device is a digital innovation that could ensure the safety of pregnant women at high risk and their fetuses through early detection and management of fetal distress. Research is scarce on factors that affect the implementation of fetal heart monitoring using the mobile cardiotocograph device in low-resource settings, including Tanzania. This study aimed to explore the barriers and facilitators of fetal monitoring with a mobile cardiotocograph device in Tanzania.

Methods
We adopted an exploratory qualitative study to analyze the barriers and facilitators of fetal monitoring using the mobile cardiotocograph device in primary healthcare facilities. Seventeen face-to-face in-depth interviews with healthcare providers and seven focus group discussions with women were conducted. Braun and Clarke’s thematic analysis guided the data analysis. It included the following steps: familiarizing with data, generating initial codes, searching for themes, reviewing themes, defining and naming themes, and producing the report.

Results
Three themes emerged as barriers: individual-related ones, including inadequate knowledge and skills to use mobile cardiotocograph devices, institutional barriers attributed to limited referral infrastructures and staff shortage, and community-related barriers, such as myths and misconceptions that limit antenatal care checkups. Individual factors, including motives and desires of healthcare providers and community trust in the healthcare system, support systems related to training and mentorship opportunities for healthcare providers, and the availability of community-based health programs in the respective areas, were revealed as facilitators of mobile cardiotocograph devices.

Conclusion
Implementing iCTG in primary healthcare facilities is affected by several factors, from individual to institutional level. Providing user-friendly procedure manuals and training on the functions of the iCTG device and cardiotocograph interpretations could serve as potential solutions to improve the competence and confidence of healthcare providers. Moreover, the availability of supportive infrastructure, adequate human resources for health, and community sensitization were good points to start with when addressing institutional and community barriers. Nevertheless, multistakeholder engagement during the design and implementation of fetal monitoring using a mobile cardiotocograph device is warranted.
HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption
Authors: Zhou Kaiyi , Luo Siyu , Wang Qinxiao , Ye Qian , Fang Sheng 
Published: December 2024

Background
Tight junction abnormalities are a common feature of inflammatory skin diseases such as psoriasis and atopic dermatitis and contribute to systemic immune responses. Evidence provided to date suggests that Heat shock protein 105 kDa (HSP105) exhibits significant protective effects in response to destructive external stimuli. However, its role in UV-induced skin tight junction remains to be fully understood.

Objective
To investigate the role and underlying mechanisms of HSP105 in acute UVB-induced tight junction damage.

Methods
By utilizing bioinformatics analysis, together with an in vitro UVB-induced tight junction injury model in HaCaT cells, we investigated the expression and localization of HSP105 and the tight junction proteins CLDN1, CLDN4, and OCLN. The role of HSP105 was further explored through shRNA-mediated silencing and lentiviral overexpression in HaCaT cells. Potential pathways by which HSP105 regulates tight junction were analyzed using the GSEA algorithm and validated through in vitro experiments.

Results
Acute UVB irradiation mainly disrupted the distribution of CLDN1, CLDN4, and OCLN in HaCaT cells, while gene expression remained largely unaffected. Acute UVB irradiation also caused a reduction in HSP105 protein levels in HaCaT cells. Inhibition of HSP105 expression worsened tight junction fragmentation. GSEA analysis showed that Store-operated calcium entry (SOCE) was significantly correlated with HSP105 expression. Silencing HSP105 downregulated STIM1 transcription and inhibited SOCE, leading to further fragmentation of tight junction proteins. Overexpression of HSP105 partially mitigated the damage to tight junction integrity caused by UVB and SOCE inhibition.

Conclusion
HSP105 protects against acute UVB-induced tight junction damage through the regulation of SOCE. Our findings offer new insights into the treatment of skin barrier injury.