bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed Cationic Surfactant Vesicles in (Dioctadecyldimethylammonium Bromide)/NaCl and (Dioctadecyldimethylammonium Chloride)/NaBr Aqueous Dispersions
Authors: Feitosa Eloi , Lemos Monique , Adati Renata D. 
Published: July 2019

AbstractOne of the most challenging characteristics not fully understood yet of the cationic surfactant salt dioctadecyldimethylammonium (DODA+) halide is concerned with the effects of the counterion (usually Br− and Cl−) on the surfactant assembly into vesicle structures in aqueous solution. These counterions play a key role in the self‐organization of DODA+ into bilayer structures. Differential scanning calorimetry (DSC) and dynamic light scattering (DLS) techniques were used here to investigate systematically the effects of the single salts NaCl and NaBr, respectively, on the thermal behavior and structural organization of the cationic dioctadecyldimethylammonium bromide and chloride (DODAB and DODAC) in water. The results undoubtedly indicate that the added Br− or Cl−, respectively, into DODAC and DODAB aqueous dispersions, replaces partially the bound counterions (Cl− and Br−) from the vesicles, yielding formation of DODAB/DODAC mixed vesicles. As a conclusion, single salts may be used to tune the thermal and structural characteristics of cationic vesicles.
From comrades to Bodhidharma: A Bourdieusian analysis of the spiritual experience of Chinese seasonal tourists
Authors: Zhang Yang , Lee Timothy J. , Xiong Yu 
Published: July 2019

AbstractThis study analyzed the role of Zen meditation in shaping seasonal tourists' spiritual experience using a focus group and interview approach. Three main themes emerged from the study: (a) the desire for seasonal tourism Zen meditation induced by local hosts and the environment was generally positive; (b) the attributes of these seasonal tourists reinforced a positive image of Zen meditation through experiences of both sacred Buddhist rituals and secular daily practices in the E'Mei Mountain destination; and (c) the positive spiritual experiences through seasonal Zen meditation gained in the tourism period had a strong impact on these participants' spiritual experiences.
Automorphisms of Hilbert schemes of points on a generic projective K3 surface
Authors: Cattaneo Alberto 
Published: July 2019

AbstractWe study automorphisms of the Hilbert scheme of n points on a generic projective K3 surface S, for any . We show that is either trivial or generated by a non‐symplectic involution and we determine numerical and divisorial conditions which allow us to distinguish between the two cases. As an application of these results we prove that, for any , there exist infinitely many admissible degrees for the polarization of the K3 surface S such that admits a non‐natural involution. This provides a generalization of the results of [7] for .
Biallelic germline BRCA1 mutations in a patient with early onset breast cancer, mild Fanconi anemia‐like phenotype, and no chromosome fragility
Authors: Keupp Katharina , Hampp Stephanie , Hübbel Annette , Maringa Monika , Kostezka Sarah , Rhiem Kerstin , Waha Anke , Wappenschmidt Barbara , Pujol Roser , Surrallés Jordi , Schmutzler Rita K. , Wiesmüller Lisa , Hahnen Eric 
Published: July 2019

AbstractBackgroundBiallelic BRCA1 mutations are regarded either embryonically lethal or to cause Fanconi anemia (FA), a genomic instability syndrome characterized by bone marrow failure, developmental abnormalities, and cancer predisposition. We report biallelic BRCA1 mutations c.181T > G (p.Cys61Gly) and c.5096G > A (p.Arg1699Gln) in a woman with breast cancer diagnosed at the age of 30 years. The common European founder mutation p.Cys61Gly confers high cancer risk, whereas the deleterious p.Arg1699Gln is hypomorphic and was suggested to confer intermediate cancer risk.Methods and ResultsAside from significant toxicity from chemotherapy, the patient showed mild FA‐like features (e.g., short stature, microcephaly, skin hyperpigmentation). Chromosome fragility, a hallmark of FA patient cells, was not present in patient‐derived peripheral blood lymphocytes. We demonstrated that the p.Arg1699Gln mutation impairs DNA double‐strand break repair, elevates RAD51 foci levels at baseline, and compromises BRCA1 protein function in protecting from replication stress. Although the p.Arg1699Gln mutation compromises BRCA1 function, the residual activity of the p.Arg1699Gln allele likely prevents from chromosome fragility and a more severe FA phenotype.ConclusionOur data expand the clinical spectrum associated with biallelic BRCA1 mutations, ranging from embryonic lethality to a mild FA‐like phenotype and no chromosome fragility.
POGZ de novo missense variants in neuropsychiatric disorders
Authors: Zhao Wenjing , Quan Yingting , Wu Huidan , Han Lin , Bai Ting , Ma Linya , Li Bin , Xun Guanglei , Ou Jianjun , Zhao Jingping , Hu Zhengmao , Guo Hui , Xia Kun 
Published: July 2019

AbstractBackgroundDe novo likely gene‐disrupting variants of POGZ cause autism spectrum disorder (ASD) and intellectual disability. However, de novo missense variants of this gene were not well explored in neuropsychiatric disorders.MethodsThe single‐molecule molecular inversion probes‐based targeted sequencing method was performed on the proband. Variant was validated using Sanger sequencing in both proband and parents. Immunoblot analysis was performed to examine the expression of POGZ in patient‐derived peripheral blood lymphocytes. Published POGZ de novo missense variants in neuropsychiatric disorders were reviewed.ResultsWe detected a novel de novo missense variant in POGZ (c.1534C>A, p.H512N, NM_015100.4) in an individual with ASD. Immunoblot analysis revealed a dramatic reduction in POGZ protein in patient‐derived peripheral blood lymphocytes suggesting a loss‐of‐function mechanism of this de novo missense variant. In addition, we collected and annotated additional eight POGZ de novo missense variants identified in neuropsychiatric disorders from literatures.ConclusionOur findings will be beneficial to the functional analysis of POGZ in ASD pathogenesis, and for genetic counseling and clinical diagnosis of patients with POGZ de novo missense variants.
Benserazide Perturbs Kif15‐kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture
Authors: Sebastian Jomon , Rathinasamy Krishnan 
Published: July 2019

AbstractThe interaction of Kif15 with kinesin binding protein (KBP) is critical for its microtubule localization, bundling of kinetochore microtubules and proper alignment of chromosomes at the metaphase plate. The Kif15‐KBP structure was prepared from the crystal structure of Kif15 and nonhomologous model of KBP through docking. Benserazide was retrieved when we did a screening of the ZINC Drug Database using the pharmacophore model generated from the potential binding site on Kif15 in an effort to identify molecules for repurposing as Kif15 inhibitors. Live cell imaging of HeLa cells revealed that benserazide delayed metaphase to anaphase‐onset by 47±10 min compared to control cells. Benserazide treatment perturbed the kinetochore and microtubule interaction and inhibited the proliferation of HeLa cells with an IC50 of 101 μM with a mitotic block of 12 %. It did not bind to tubulin in the in vitro assays suggesting that the observed effects could be due to its perturbation of Kif15‐KBP interaction.
Education campaign and family understanding affect stability and qualitative behavior of an online game addiction model for children and youth in Thailand
Authors: Viriyapong Ratchada , Sookpiam Monthicha 
Published: July 2019

Online game addiction has become a large problem worldwide, and it could give negative impacts on children in many ways such as physical health, learning, emotion, and behavior. Online game addiction is mostly found in children and youth at the age of 15 to 24 years. Therefore, in this paper, we have developed a mathematical model of online game addiction to explore the effects of education campaign and family understanding on online game addiction in Thailand. Analysis of this model reveals two main equilibria, addiction‐free (AFE) and addiction‐present (APE) ones. Results show that the AFE is locally asymptotically stable when the value of basic reproduction number (R0) is less than the unity; otherwise, there is a unique endemic equilibrium point, and it is locally stable when satisfies the Routh‐Hurwitz criterion. Further, the conditions of AFE to be globally stable are demonstrated. Finally, the results of sensitivity analysis and numerical simulation show that the effectiveness of both education campaign and family understanding is an important factor in reducing the value of R0 and holds great promise for lowering the number of children and youth who addict to online game in Thailand.
Ultra‐wideband crossover with a reversed polarity channel designed with normalized Euclid distance for fast pulse transmission
Authors: Zhang Qiuyi , Li Shunli , Yang Mei , Yin Xiaoxing , Zhao Hongxin , Liu Leilei 
Published: July 2019

AbstractAn ultra‐wideband pulse crossover with a reversed polarity channel is proposed, and a time‐domain analysis is utilized to design the crossover and estimate its performance. Two crossed channels are designed based on post‐wall slotline (PWS) and conventional slotline, and one of the two channels provides an output with reversed polarity. At the overlapping region, the PWS degrades to slotline on single layer to improve isolation between channels. Normalized Euclid distance of short pulses is utilized to evaluate the isolating and polarity reversing features of the crossover, and the matrices of normalized Euclid distance are then obtained and applied to the design procedure. The proposed crossover are modeled and fabricated for simulation and measurement, and the simulated and measured results agree well. Minimum of return loss and isolation is more than 12 dB within an ultra‐wide bandwidth from DC to 8.5 GHz. Moreover, in time domain, the proposed crossover shows good performance in pulse transmission, including high fidelity and amplitude ratio of input and output signals. The characteristics of the crossover indicate the practicability in short pulse application, and rectangular pulse transmission performance is evaluated to verify the ability.
Dual band modified circular ring shaped slot antenna for GSM and WiMAX applications
Authors: Gangwar Som Pal , Gangwar Kapil , Kumar Arun 
Published: July 2019

AbstractIn this article, a modified circular ring shaped slot antenna is presented for dual‐band wireless applications. Dual frequency bands are achieved by combining the circular ring shaped slot with U‐shaped slot. Analysis of proposed radiator has been carried out on HFSS EM simulator. For experimental verification, the prototype of proposed radiator is fabricated and tested. Experimental results confirm that the proposed radiator operates over dual frequency bands, that is, 1.69 to 1.94 GHz and 3.64 to 3.88 GHz with the impedance bandwidth of 14.1% and 6.4%, respectively. Far‐field features of proposed radiator are stable and confirm its better performance in between dual frequency range. The proposed antenna can be used for global system for mobile (GSM) (1.8 GHz) and Worldwide Interoperability for Microwave Access (WiMAX) (3.7 GHz) applications.
Technical Note: Sheet‐based dynamic beam attenuator – A novel concept for dynamic fluence field modulation in x‐ray CT
Authors: Huck Sascha Manuel , Fung George S. K. , Parodi Katia , Stierstorfer Karl 
Published: July 2019

PurposeIt has been a long‐standing wish in computed tomography (CT) to compensate the emitted x‐ray beam intensity for the patient's changing attenuation during the rotation of a CT data acquisition. The patient attenuation changes both spatially, along the fan beam angle, and temporally, between different projections. By modifying the pre‐patient x‐ray intensity profile according to the attenuation properties of the given object, image noise can be homogenized and dose can be delivered where it is really needed. Current state‐of‐the‐art bowtie filters are not capable of changing attenuation profiles during the CT data acquisition. In our work, we present the sheet‐based dynamic beam attenuator (sbDBA), a novel technical concept enabling dynamic shaping of the transmission profile.MethodsThe sbDBA consists of an array of closely spaced, highly attenuating metal sheets, focused toward the focal spot. Intensity modulation can be achieved by controlled defocusing of the array such that the attenuation of the x‐ray fan beam depends on the fan angle. The sbDBA concept was evaluated in Monte‐Carlo (MC) simulations regarding its spectral and scattering properties. A prototype of the sbDBA was installed in a clinical CT scanner and measurements evaluating the feasibility and the performance of the sbDBA concept were carried out.ResultsExperimental measurements on a CT scanner demonstrate the ability of the sbDBA to produce an attenuation profile that can be changed in width and location. Furthermore, the sbDBA shows constant transmission properties at various tube voltages. A small effect of the flying focal spot (FFS) position on the transmission profile can be observed. MC simulations confirm the essential properties of the sbDBA: In contrast to conventional bowtie filters, the sbDBA has almost no impact on the energy spectrum of the beam and there is negligible scatter emission toward the patient.ConclusionsA new concept for dynamic beam attenuation has been presented and its ability to dynamically shape the transmission profile has successfully been demonstrated. Advantages compared to regular bowtie filters including the lack of filter‐induced beam hardening and scatter have been confirmed. The novel concept of a DBA paves the way toward region of interest (ROI) imaging and further reductions in patient dose.
Flexible bodies—Restricted lives: A qualitative exploratory study of embodiment in living with joint hypermobility syndrome/Ehlers‐Danlos syndrome, hypermobility type
Authors: Sætre Elisabeth , Eik Hedda 
Published: July 2019

AbstractPurposeThe aim of this study was to explore embodiment as a meaning‐making experience in the daily life of Norwegian adults living with joint hypermobility syndrome/Ehlers‐Danlos syndrome, hypermobility type (JHS/EDS‐HT). The work of Drew Leder and his distinction between bodily dis‐ and dys‐appearance contributes to the description and analysis of individuals' bodily experiences of living with this chronic illness.MethodsAn explorative and qualitative design was applied to in‐depth interviews with seven participants. The theoretical framework was phenomenological, and the method of analysis was thematic, involving descriptive and interpretative approaches.ResultsParticipants' bodily experiences were closely connected to a timeline viewing their illness in the past, the present and from future perspectives. The following central themes emerged from the data: (a) visible to invisible signs of a former body; (b) standing up and falling down of a present body; and (b) future thoughts of an inner and outer body.ConclusionsThe study found that living with JHS/EDS‐HT revealed complex experiences of having flexible bodies and restricted lives. Our findings also showed a meaning‐making process of embodied experiences that evolved over time, as well as a sliding transition from social to personal dys‐appearance. In the course of time, a bodily disruptions in social interactions comes to the fore, with invisible symptoms such as pain and fatigue. Individual bodily suffering determines the existence of hope or hopelessness regarding recovery from this condition.
Building an Ecosystem for 8K
Authors: Dickson Glen 
Published: July 2019

AbstractThe consumer electronics industry has big plans for 8K—and a host of complex delivery challenges that stand in its way. A recent summit of content creators, set makers, retail partners, and others in the supply chain laid out the ongoing issues as well as some new opportunities. Here's a look at what they said and some of the innovations shown to accelerate 8K TV adoption.
An intelligent response surface method for analyzing slope reliability based on Gaussian process regression
Authors: Zhu Bin , Pei Huafu , Yang Qing 
Published: July 2019

SummaryProblems in geotechnical engineering inevitably involve many uncertainties in the analysis. Reliability methods are important for evaluating slope stability and can take the uncertainties into consideration. In this paper, a novel intelligent response surface method is proposed in which a machine learning algorithm, namely Gaussian process regression, is used to approximate the high‐dimensional and highly nonlinear response hypersurface. An iterative algorithm is also proposed for updating the response surface dynamically by adding the new training point nearest to the limit state surface to the initial training database at each step. The proposed Gaussian process response surface method is used to analyze three different case studies to assess its validity and efficiency. Direct Monte Carlo simulation is also carried out in each case to serve as the benchmark. Comparing with other methods confirms the accuracy and efficiency of the novel intelligent response surface method, which requires fewer performance function calls and avoids the need to normalize the correlative non‐normal variables.
Estimation of cellular‐interstitial water exchange in dynamic contrast enhanced MRI using two flip angles
Authors: Zhang Jin , Kim Sungheon Gene 
Published: July 2019

PurposeTo investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi).MethodsNumerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MRI with one or two flip angles. In vivo experiments with a murine brain tumor model were conducted at 7T using two flip angles. The in vivo data were used to compare τi estimation using the single‐flip‐angle (SFA) protocol with that using the double‐flip‐angle (DFA) protocol. Data analysis was conducted using the two‐compartment exchange model combined with the three‐site‐two‐exchange model for water exchange.ResultsIn the numerical simulation studies with a range of contrast kinetic parameters and signal‐to‐noise ratio = 20, the median bias of τi estimation decreased from 72 ms with SFA to 65 ms with DFA, and the corresponding median inter‐quartile range reduced from 523 ms to 156 ms. In the in vivo studies, τi estimation with SFA was not successful in most voxels in the tumors, as the estimated τi values reached the upper limit of the parameter range (2 s). In contrast, the estimated τi values with DFA were mostly between 0.2 and 1.5 s and homogeneously distributed spatially across the tumor. The τi estimation with DFA was less sensitive to arterial input function scaling but more sensitive to pre‐contrast T1 than the other contrast kinetic parameters.ConclusionThis study results demonstrate the feasibility of using multiple flip angles to encode the post‐contrast time‐intensity curve with different weighting of water exchange effect to reduce the uncertainty in τi estimation.
Maximum‐norm a posteriori error bounds for a collocation method applied to a singularly perturbed reaction–diffusion problem in three dimensions
Authors: Radojev Goran , Linß Torsten 
Published: July 2019

AbstractCollocation with triquadratic C1‐splines for a singularly perturbed reaction–diffusion problem in three dimension is studied. A posteriori error bound in the maximum norm is derived for the collocation method on arbitrary tensor‐product meshes which is robust in the perturbation parameter. Numerical results are presented that support our theoretical estimate.
Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing
Authors: Barman Pijus K , Urao Norifumi , Koh Timothy J 
Published: July 2019

AbstractDiabetes induces dysregulation throughout the spectrum of myeloid lineage cells from progenitors to terminally differentiated cells. Another complication of diabetes is persistent inflammation, including prolonged accumulation of macrophages, which contributes to impaired wound healing. However, it remains unclear whether diabetes disrupts the response of bone marrow progenitors to peripheral injury and whether such dysregulation leads to sustained inflammation and impaired healing. Here, we demonstrated that diabetic mice (db/db, referred to here as DB) exhibit myeloid lineage bias during homeostasis and following injury. In addition, cells in the LSK (Lin−Sca‐1+cKit+) population of DB mice are preprogrammed towards myeloid commitment at the transcriptional level, and cultured myeloid progenitors from DB mice produce more monocytes ex vivo than their non‐diabetic counterparts. We also show via bone marrow transfer between interleukin‐1 receptor 1 KO (Il1r1−/−) and DB mice that IL‐1R1 signaling is likely not involved in myeloid skewing in DB mice. Furthermore, in vitro experiments indicated that macrophage colony‐stimulating factor receptor signaling is not likely involved in enhanced myeloid transcription factor expression in LSK cells of DB mice. Our findings indicate that myeloid lineage commitment in bone marrow may contribute to increased macrophage numbers observed in diabetic skin wounds, and that strategies to regulate monopoiesis during homeostasis or post‐wounding may improve diabetic wound healing. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Preparation and characterization of flexible, free‐standing, and easy‐fabricating BaTiO3‐P(VDF‐CTFE) dielectric nanocomposite
Authors: Tong Yang , Li Leyi , Liu Jiachen , Li Yugui 
Published: July 2019

AbstractThe flexible and free‐standing nanocomposite films were fabricated by a simple solution‐casting process using BaTiO3 nanoparticles as fillers and P(VDF‐CTFE) 91/9 mol% as polymer matrix. To obtain good wettability between ceramic and polymer, the coupling agent 3‐Aminopropyltriethoxysilane was used to modify the surface of BaTiO3 fillers. A good compatibility of BaTiO3 and P(VDF‐CTFE) was achieved when a small amount of coupling agent was used for the surface modification of BaTiO3 fillers; therefore, the nanocomposites with a dense and uniform microstructure was obtained. It was experimentally found that both dielectric constant and breakdown strength were increased with a suitable amount of coupling agent due to the good compatibility. A dielectric constant of 51 at 1 kHz was obtained with 30 vol% fillers and 2 wt% coupling agent, which was about four times of that for the pure P(VDF‐CTFE) film. When an appropriate amount of coupling agent was coated on fillers, the energy storage density of the composite system was improved. A maximal discharge energy‐storage density of 3.8 J/cm3 was obtained for the nanocomposite film with 5 vol% of BaTiO3 and 2 wt% coupling agent, which is much higher than that of the composites without coupling agent.