bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient related outcomes in cancer patients in Croatia.
Authors: Trivanovic Dragan , Hrstic Irena , Budisavljevic Anuska , Kopic Boris , Nincevic Bruno 
Published: May 2019

TPS6650 Background: Accurate evaluation of symptom intensities is essential for optimal cancer care and improving the quality of life of patients. An inappropriate interpretation of symptoms may lead to treatment outcomes failure, overdose of medication, or may leave the patients undertreated. However, the perception of symptoms can vary between the treating physician and patient. Physicians appear to underestimate the patient symptoms. And this variation in the perception of side effects can lead to wrong assumptions and subsequent treatment changes, affecting treatment effectiveness and quality of life. There is growing interest to enhance symptom monitoring during routine cancer care using patient-reported outcomes, leaving open the question of whether the benefits of systems to reveal self-reports outweigh their added cost. There are several tools for assessment of symptoms in oncology. In cancer treatment clinical trials, the standard source of adverse symptom data is clinician reporting by use of items from PRO-CTCAE, developed by NCI. To address these questions, we conducted a single-center prospective trial to test whether systematic tablet computer-based collection of patient-reported symptoms during chemotherapy treatment, with automated alerts to clinicians for severe adverse events (grade 3-4) will change in questionnaire score at 6 months compared with baseline. Secondary endpoints will include difference in unscheduled clinic visits frequency, and survival. Methods: Patients initiating chemotherapy at General Hospital Pula Oncology Clinic for advanced or metastatic gastrointestinal, lung, breast, genitourinary, or gynecologic cancers will be enrolled in a nonblinded, prospective trial of self-reporting of symptoms, compare with usual care. Patients receiving chemotherapy and their clinicians will be independently asked on the same day to complete 10 symptoms (including fatigue, pain, nausea, vomiting, diarrhea, dysgeusia, appetite, sleep disturbance, fever and hair loss). Participants will remain on study until discontinuation of cancer treatment, withdrawal, or death. All participants will provide written informed consent and followed for up to 28 months or until death. To compare how patient’s vs clinician’s reports relate to clinical events, a time-dependent Cox regression model adjusted for covariates including cancer type, age, sex, and education level will be used to measure associations between reaching particular grade severity thresholds with the risk of death and unscheduled clinic visits. Clinical trial information: 2019-000855-15.
Pembrolizumab versus placebo as adjuvant therapy in resected high-risk stage II melanoma: Phase 3 KEYNOTE-716 study.
Authors: Carlino Matteo S. , Ascierto Paolo Antonio , Eggermont Alexander M. , Gershenwald Jeffrey E. , Grob Jean Jacques , Hauschild Axel , Kirkwood John M. , Long Georgina V. , Mohr Peter , Robert Caroline , Ross Merrick I. , Scolyer Richard A. , Sondak Vernon K. , Yoon Charles , Poklepovic Andrew Stewart , Rutkowski Piotr , Anderson James R. , Ahsan Sama , Ibrahim Nageatte , Luke Jason J. 
Published: May 2019

TPS9596 Background: Adjuvant pembrolizumab showed significantly longer recurrence-free survival than placebo in patients with resected stage III melanoma in the KEYNOTE-054 study. KEYNOTE-716 (NCT03553836) is a randomized, placebo-controlled, double-blind, multicenter phase 3 study of adjuvant pembrolizumab in patients with surgically resected high-risk stage II melanoma. Methods: Key eligibility criteria are age ≥12 y with newly diagnosed, completely resected stage IIB/IIC cutaneous melanoma, defined by the AJCC Cancer Staging Manual, 8th edition (wide excision and negative sentinel lymph node biopsy with no evidence of distant metastasis). Patients with mucosal or uveal melanoma or prior treatment (including radiation) for melanoma beyond resection of primary disease within 12 wk of the start of study treatment were excluded. In this 2-part study, in the double-blind phase (part 1), patients will be randomly assigned 1:1 to receive pembrolizumab 200 mg for patients ≥18 y or 2 mg/kg for patients ≥12 y to < 18 y (maximum dose, 200 mg) or placebo every 3 wk for 17 cycles. Study treatment will begin within 12 wk of complete resection. Tumor imaging will be performed every 24 wk while treatment is ongoing, at the end of treatment, every 6 mo for the first 3 y off treatment, and then yearly for up to 2 y or until recurrence (up to 5 y of total imaging). Adverse events will be recorded until 30 d after treatment end (90 d for serious AEs) and graded per National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. In the unblinded phase (part 2), patients with confirmed recurrence may be rechallenged (patients received pembrolizumab in part 1) or crossed over to pembrolizumab (patients received placebo in part 1). Resected local or distant recurrence or unresectable disease will be treated for an additional 17 or 35 cycles, respectively. Tumor imaging in part 2 will occur every 12 wk during treatment. The primary end point is recurrence-free survival; secondary end points are distant metastasis-free survival, overall survival, and safety. Approximately 954 patients will be enrolled. Clinical trial information: NCT03553836.
Pilot integrated biomarker study of VX15/2503 in combination with ipilimumab and/or nivolumab in patients with resectable metastatic melanoma.
Authors: Lowe Michael C. , Lesinski Gregory B. , Delman Keith A. , Yushak Melinda Lynne , Evans Elizabeth E. , Fisher Terrence Lee , Kudchadkar Ragini Reiney 
Published: May 2019

TPS9603 Background: Interrogation of the tumor microenvironment (TME) is crucial to provide insight into biological activity, resistance mechanisms and implementation of rational combination immunotherapies. Semaphorin 4D (SEMA4D, CD100) has broad immunomodulatory effects in the TME. In preclinical models, blockade of SEMA4D promoted immune infiltration and reduced recruitment of immunosuppressive myeloid cells. Preclinical combinations of anti-SEMA4D with immune checkpoint inhibitors (ICIs) enhanced T cell activity and tumor regression. VX15/2503 (pepinemab), an IgG4 humanized monoclonal antibody targeting SEMA4D, is being evaluated in an integrated biomarker trial to characterize immunomodulatory effects in melanoma (NCT03769155). Methods: Patients with biopsy-proven stage IIIB, C, and D melanoma are eligible. Prior to curative-intent surgery, patients receive pepinemab alone or in combination with nivolumab and/or ipilimumab every three weeks for two doses. A control cohort proceed directly to surgery. Resection specimens will be collected for comparison across treatment groups and with a pre-treatment biopsy. Blood will be collected for PK, PD, and correlative biomarker assessments. The primary objective is to evaluate effects on the immune profile in TME and peripheral blood. Additional objectives include safety of pepinemab (alone and in combination with ICI), and pathologic and radiographic responses. Multiplex flow cytometry panels were created to phenotype cells in the TME and periphery. A multiplex IHC assay utilizing a sequential probe and strip procedure has been qualified that allows co-localization, orientation, and quantification of multiple immune markers. Analysis of immune subsets include cytotoxic T cells, neutrophils, Tregs, DCs, monocytes, macrophages, and myeloid-derived suppressor cells. Target engagement and expression of SEMA4D and its receptors will be evaluated. As of 01 Feb 2019, 8 of 36 patients have been enrolled. This trial will provide the first biomarker-driven clinical assessment of anti-SEMA4D antibody activity to reprogram the TME. Clinical trial information: NCT03769155.
A PERCEPÇÃO DE UM CUIDADOR A RESPEITO DA QUALIDADE DE VIDA DO IDOSO COM ALZHEIMER: RELATO DE EXPERIÊNCIA DO PROJETO TEORIAS E PERSPECTIVAS EM ENVELHECIMENTO HUMANO
Authors: COSTA André Felipe da , SILVA Ana Maria Costa da , VICENTE Aline Janete , ALMEIDA Mayara de Paula , BOSSARDI Carina Nunes 
Published: May 2019

O presente estudo faz parte de um projeto desenvolvido durante umadisciplina da graduação em Psicologia. Para se discutir a respeito das perspectivas em envelhecimento humano, objetivou-se conhecer a percepção de um cuidador sobre a qualidade de vida do idoso com Alzheimer, com base em suas expectativas, experiências e ações em relação a essa situação. Esta pesquisa é de caráter qualitativo, com a qual foi realizado um estudo de caso de um cuidador. Como método foram utilizadas uma entrevista semiestruturada e a análise de conteúdo de Bardin. Com base na autopercepção desse cuidador, nota-se a importância da espiritualidade, remédios, profissionais e de Políticas Públicas para a manutenção da qualidade de vida de ambos, sendo que esta évista, em geral, como positiva, mas cheia de desafios devido à mudança que a relação que o cuidador e o idoso sofrem no decorrer do tempo. A discussão dos dados foi baseada na Teoria do Curso de Vida de Paul Baltes, perspectiva expressiva na compreensão dos processos de desenvolvimento e de envelhecimento humano. Os resultados salientam a necessidade de novas pesquisas a respeito do tema e indicam a importância de discussões desde as salas de aula, voltadas à realidade da população. Espera-se que esse estudo tenha implicações na formação dos profissionais de graduação, tendo em vista possibilidades de interverção visando à promoção de saúde dos idosos e de seus cuidadores.
PERCEPÇÃO DA EQUIPE TÉCNICA SOBRE AS PRÁTICAS CORPORAIS NA REDUÇÃO DE DANOS EM DEPENDENTES QUÍMICOS
Authors: MANSKE George Saliba , ONISHI Luiz Antonio 
Published: May 2019

Esta pesquisa teve como objetivo compreender a percepção da equipe técnicade um Centro de Atenção Psicossocial (CAPS-ad) num município do sul do Brasil sobre as influências das práticas corporais na redução de danos nos dependentes químicos. Os dados foram coletados por meio de uma entrevista semiestruturada, sendo analisados sob a ótica da análise temática. Os resultados da pesquisa demonstram que a equipe técnica possui conhecimento sobre as práticas corporais e, mesmo não conhecendo todo o universo desta atividade, acredita que deveria fazer parte do rol de opções a serem ofertadas quando da estruturação dos Projetos Terapêuticos Singulares (PTS).
RACIONALIZAÇÃO DAS AÇÕES DE CONTROLE INTERNO E AUDITORIA COMO PROCESSO DE CONTROLE NA GESTÃO DA SAÚDE EM UNIDADES HOSPITALARES NO CONTEXTO BRASILEIRO
Authors: GUERINI Isabelle Christine , GUERINI Eduardo 
Published: May 2019

O presente artigo tem como objetivo descrever sucintamente a racionalizaçãodas ações de controle interno e auditoria nas gerências das unidades hospitalares no contexto brasileiro. A necessidade de mecanismos de gestão com implantação de auditagem derivou da necessidade de controles internos para melhoria contínua na gestão hospitalar, como resultado de um processo derivado da universalização proposta na regulação jurídica, garantindo a universalização do acesso, destacando uma clara orientação para estabelecimento de metas quantitativas e qualitativas. Elaborou-se brevehistórico da implantação e da implementação de práticas gerenciais no sistema de saúde brasileiro, a racionalização, resultante de políticas públicas que são monitoradas por padrões de desempenho com resultados vinculados ao planejamento e cumprimento de metas almejadas. Neste sentido, observou-se que, no sistema de saúde pública ou privada, as variadas formas de organização hospitalar têm como claro resultado a transparência dos processos – elementos preponderantes para efetivação da prática de auditagem interna e externa nas unidades hospitalares no contexto brasileiro.
DESAFIO ÉTICO NA COMUNICAÇÃO DE HISTÓRIAS DE VIDAS COM ESCLEROSE SOBRE ÉTICA MÚLTIPLA
Authors: VENERA Raquel Alvarenga Sena , BRUNKEN Pedro Antônio Testoni , GOMES Jessica Fernanda , VENERA José Isaías 
Published: May 2019

Este artigo traz reflexões teóricas construídas no Grupo de PesquisaSubjetividades e (auto)biografias. Trata-se de duas pesquisas de iniciação científica e inovação que desenvolveram produtos diferentes para comunicar Histórias de Vidas de pessoas diagnosticadas com Esclerose Múltipla. Ambas dialogaram de forma interdisciplinar com a Comunicação, especialmente com a ética no Jornalismo, a História e o Patrimônio Cultural, mas, sobretudo, estiveram atentas à questão ética das pesquisas (auto)biográficas. Com o foco na ética e nas epistemologias que nortearam decisões para as edições dessas histórias, a questão “O que fazer com a palavra do outro?” (ARFUCH,2010) foi a pergunta que perseguiu o trabalho. A exploração do trauma em uma mídia, ou a espetacularização da ‘superação’, ou ainda a sensibilidade para a conscientização da doença foram decisões conscientes do trabalho de comunicação e nessas pesquisas funcionaram como caminho reflexivo para pensar os campos envolvidos.
Major structural elements and petrophysical properties of the miocene section, â€œXYZ Fieldâ€, western shallow Offshore Depobelt, Niger Delta
Authors: M.A Ajibade , Adekola Ajibade , Olowokere M.T. 
Published: May 2019

R1, R2, R3, and F. reservoir units were identified in the XYZ Field. The reservoirs are within the Oil proven fault block and F reservoir is located on the footwall structure of the second synthetic fault with similar structural characteristics. The faulting in the XYZ field resulted in a downward movement of the XYZ Discovery relative to the XYZ prospects. The structural development process of the field was a syn-sedimentary. This explains why the XYZ-1 penetration in the footwall of the synthetic found oil-in F sand. However, petrophysical results show that the reservoirs of interests have good petrophysical properties with minimum porosity of 0.1 and maximum water saturation of 0.7. The discoveries by the XYZ-1 well prove the existence of a working hydrocarbon source and charge system. However the distribution pattern of the discovered hydrocarbons is not yet understood.Â Â
DAMPAK PERUBAHAN GUNA LAHAN TERHADAP KEMAMPUAN RESAPAN AIR (KASUS: KOTA SAMARINDA)
Authors: Warsilan Warsilan 
Published: May 2019

As the capital of the province of East Kalimantan, Samarinda City developments has a rapid progress from year to year. Samarinda City Development has a tendency oriented towards infrastructure development without regard to the existence of the quality of the existing environment. Imbalance of development in Samarinda city is to start decreasing the water catchment area, so its make increasing intensity of flood in the Samarinda City. The purpose of this study was to analyze the impact of changes in land use in the Samarinda city on the ability of the water catchment area. This research method using descriptive approach, the data collection system of primary and secondary. Intensity flood in the Samarinda city is increasing from year to year, this condition happened as a problem that always occurs during the rainy season. Current development trends, always take an area that should be an infiltration area for Samarinda City. Culture and inadequate infrastructure conditions such as lack of system of drainage and polder, was another factor causing the high intensity of flood in Samarinda City. Therefore, the relevant regulations development guidelines for Samarinda City must consider all aspects of planning, in this case especially the important of a balance of cultivated land and protected areas or zones.Keywords: Changes in land use; intensity of puddles; Samarinda
‘For We Are American’: Postmodern Pastiche and National Identity in Anne Washburn’s Mr. Burns, a Post-Electric Play
Authors: Barrera Camille 
Published: May 2019

Abstract
The final act of Anne Washburn’s Mr. Burns, a Post-Electric Play features a Greek tragedy-like distillation of the “Cape Feare” episode of The Simpsons, performed many decades after an unspecified catastrophe has left the former United States in a state of post-apocalyptic ruin. After the first two acts’ depiction of an earlier generation’s struggles to both survive and connect with each other through the preservation of some elements of their previous shared culture, the third act’s culmination in a display of treadmill-powered electric lights accompanied by an inspirational anthem has often been interpreted as a celebration of the timelessness and tenacity of the human storytelling impulse. But while earlier versions of the play structured this final moment within a pastiche expression of American patriotism (sung to the tune of Gilbert and Sullivan’s “For He Is an Englishman”), subsequent versions have expunged this final reference to national pride, as well as any reference to the satirically nationalistic source material from which it stemmed, opting instead to trace the development of a more ‘empty’ G&S quotation into its post-apocalyptic future. This paper will examine the implications of this change in regards to the play's pastiche portrayal of what Jean-Luc Nancy calls the “myth of myth” and the role of its interruption in imagining an “inoperative community” beyond or to the side of nation-based constructions of identity.
‘The State of Us’: Challenging State-Led Narratives through Performance during Ireland’s ‘Decade of Centenaries’
Authors: Murphy Ciara L. 
Published: May 2019

Abstract
Ireland is currently at the mid-point of what has been termed The Decade of Centenaries, where citizens, artists, the Irish diaspora, and the tourist industry are encouraged to come together and reflect on the Ireland of one hundred years ago. The years 1912–1922 reflect some of the most significant moments in Ireland’s history, the centerpiece of which is considered to be the 1916 Easter Rising. State-led commemorations of these events have thus far been dominated by narratives around patriotism, nationalism, republicanism, and neoliberalism. There has been little to no state interest in interrogating any significant challenging of the historical events themselves, or indeed any significant exploration of any progress, changes, or diversification that may have emerged since these events. Much of the available state funding in the arts sector has been earmarked for artists to engage specifically with the commemorative schedule, thus restricting the theme of artistic output. This essay analyses how two participatory performances, which took place during the 2016 Dublin Theatre Festival, problematised the state-led narratives and illuminated divergent histories surrounding the 1916 Easter Rising: These Rooms by ANU Productions and CoisCéim Dance Theatre, and It’s Not Over by THEATREclub.
From Chimera to Reality: Lucy Kirkwood’s Chimerica or ‘What State Are We in?’
Authors: Kiehl Christine 
Published: May 2019

Abstract
Mark Ravenhill’s 2007 Shoot/Get Treasure/Repeat is a relevant state of the nation(s) play drawing an acid portrait of Anglo-American nations and their self-congratulatory ‘freedom and democracy’ propaganda in Irak. Other committed voices have made themselves heard on the British stage in addressing worldwide political and ethical issues. This paper focuses on Lucy Kirkwood, a young British dramatist whose pungent style was revealed in Tinderbox (2008), a dystopian farce set in 21st century England. Today, Lucy Kirkwood (33) who sees herself as ‘a radical young dramatist,’ continues to explore the confused landscape of western democracy: she sketched the relations between the USA and China in Chimerica (2013), an epic drama which won her an Olivier Award for Best New Play. In the wake of Brexit and the Trump election, Lucy Kirkwood has recently announced that she would pursue her investigation of the leading nations’ policies: “The whole of democracy looks fragile and farcical. After writing about communist China in Chimerica, you suddenly look at western democracy and think: is this necessarily better? Maybe this is the endgame” (Lawson, “Chimerica”).This paper explores Kirkwood’s vitriolic portrait of today’s leading nations, and her questioning of universal concerns experienced on a personal level such as power and privacy, nationalism and identity, profit and subservience. I will examine her peculiar ability to reformulate a ‘state-of-the-nation’ format and associate innovation and convention in her treatment of subject matter, language, dramatic form and performance.
Kevlar fiber-epoksi kompozit malzemesinin frezeleme işleminin faktöriyel tasarım ve hedef programlama yöntemleriyle eniyilemesi
Authors: İÇ Yusuf Tansel , ELALDI Faruk , KEÇECİ Barış , ÖNDER UZUN Gözde , LİMONCUOĞLU Nur , AKSOY İrem 
Published: May 2019

Kevlar
fiber-epoksi kompozit malzemesi, çeşitli üstün özelliklerinden dolayı
kullanımının getirdiği avantajlar nedeniyle günümüzde birçok üretim alanında
özellikle balistik koruyucu amaçlı olarak tercih edilmektedir. Kevlar
fiber-epoksi kompozit malzemesinin işlenmesi sırasında daha çok geleneksel
işleme yöntemleri kullanılmaktadır. Ancak kesme parametrelerine ait uygun
seviyeler belirlenmediği için malzemenin işlenmesi sırasında çeşitli bozulmalar
yaşanmaktadır. Makale kapsamında 2k faktöriyel tasarım tekniği ile
hedef programlama yöntemi bütünleşik olarak kullanılarak, kevlar fiber-epoksi
kompozit malzemenin frezeleme operasyonunun iki kalite karakteristiği olan
delaminasyon ve yüzey pürüzlüğünün eşzamanlı olarak eniyilenmesi
gerçekleştirilmiştir. Elde edilen sonuçlar çok ölçütlü karar verme tabanlı
Taguchi yöntemleri sonuçlarıyla karşılaştırılmıştır.
Çift hazneli döngüsel bir türbin için tasarım parametrelerinin incelenmesi
Authors: KAYACAN Murat Kenan , OKUR Melih 
Published: May 2019

Günümüzde
üzerinde yoğun çalışmalar yapılan insansız hava araçları ve hibrit otomobiller
için, yüksek verimliliğe ve güç-ağırlık oranına sahip motorlara ihtiyaç
duyulmaktadır. Bu ihtiyaçları karşılama potansiyeline sahip döngüsel bir motor
olan Pars motor, endüstride kullanılan tek paletli soğutucu kompresör ve
genleştiricilerin yapıları ile benzerlik göstermektedir. Bu çalışmada döner
valfli sisteme sahip olan Pars türbin yerine valf ve güç türbinlerinden oluşan
yeni bir çift hazneli türbin tasarlanmıştır. Tasarım parametreleri olarak,
eksantriklik oranı, hacim oranı, faz farkı açısı belirlenmiş ve moment
değerleri hesaplanmıştır. Yapılan teorik hesaplamalarda çift hazneli türbinde
döner valfli sisteme göre eşit giriş zamanı açıları için %47 moment artışı elde
edilmiştir.
FASILITAS BELAJAR DAN MANAJEMEN KELAS SEBAGAI DETERMINAN TERHADAP PRESTASI BELAJAR SISWA
Authors: Anggraini Citra , Imaniyati Nani 
Published: May 2019

Tulisan ini mengkaji secara khusus tentang fasilitas belajar dan manajemen kelas sebagai faktor yang diduga mempengaruhi prestasi belajar siswa. Regresi ganda dan korelasi product moment merupakan teknik analisis data yang digunakan untuk mengetahui kontribusi setiap variabel. Berdasarkan hasil analisis, data dikumpulkan melalui metode survey dengan menggunakan angket jawaban tertutup terhadap 78 siswa Sekolah Menengah Kejuruan di Cimahi sebagai responden. Hasil analisis menunjukkan fasilitas belajar dan manajemen kelas berkorelasi sedang terhadap prestasi belajar secara parsial, namun hasil analisis secara simultan menunjukkan korelasi yang kuat. Dari hasil penelitian ini dapat memberikan Implikasi bagi pihak sekolah maupun guru sebagai salah satu acuan untuk meningkatkan prestasi belajar siswa yang optimal.