bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of microarray datasets identify several chromosome segregation-related cancer/testis genes potentially contributing to anaplastic thyroid carcinoma
Authors: Liu Mu , Qiu Yu-lu , Jin Tong , Zhou Yin , Mao Zhi-yuan , Zhang Yong-jie 
Published: October 2018

Aim
Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid malignancy. Identification of novel drug targets is urgently needed.

Materials & Methods
We re-analyzed several GEO datasets by systematic retrieval and data merging. Differentially expressed genes (DEGs) were filtered out. We also performed pathway enrichment analysis to interpret the data. We predicted key genes based on protein–protein interaction networks, weighted gene co-expression network analysis and genes’ cancer/testis expression pattern. We also further characterized these genes using data from the Cancer Genome Atlas (TCGA) project and gene ontology annotation.

Results
Cell cycle-related pathways were significantly enriched in upregulated genes in ATC. We identified TRIP13, DLGAP5, HJURP, CDKN3, NEK2, KIF15, TTK, KIF2C, AURKA and TPX2 as cell cycle-related key genes with cancer/testis expression pattern. We further uncovered that most of these putative key genes were critical components during chromosome segregation.

Conclusion
We predicted several key genes harboring potential therapeutic value in ATC. Cell cycle-related processes, especially chromosome segregation, may be the key to tumorigenesis and treatment of ATC.
Increasing Rates of Arthroplasty for Psoriatic Arthritis in the United Kingdom Between 1995 and 2010
Authors: Lewinson Ryan T. , Vallerand Isabelle A. , LaMothe Jeremy M. , Parsons Laurie M. , Frolkis Alexandra D. , Lowerison Mark W. , Patten Scott B. , Barnabe Cheryl 
Published: October 2018

ObjectiveArthroplasty requirements among patients with psoriatic arthritis (PsA) are not well known. This information is important to clinical and policy stakeholders for health‐system planning and may serve as a surrogate for estimation of the efficacy of disease‐modifying therapy.MethodsWe utilized The Health Improvement Network (THIN), a large general practice medical records database in the UK, to assess rates of primary total arthroplasty among patients with PsA and the general population between the years 1995 and 2010. Linear regression was used to estimate arthroplasty rates for the 2 cohorts during the study period, and Poisson regression was used to determine age‐ and sex‐adjusted incidence rate ratios (IRRs) between the PsA and general population cohorts.ResultsWe identified 5,619 patients with incident PsA and 5,090,814 eligible patients from the general population between 1995 and 2010. In total, 187 primary total arthroplasties were documented in patients with PsA, and 80,163 primary total arthroplasties were documented in the general population. A trend of increasing arthroplasty rates was observed for both the PsA (R2 = 0.809; P < 0.0001) and general population (R2 = 0.890; P < 0.0001) cohorts during the study period. After adjustment for age and sex, patients with PsA had a first arthroplasty incidence rate that was twice that of the general population (IRR 2.01 [95% confidence interval 1.73–2.34]; P < 0.0001), notably beyond the year 2003 when biologic therapies were introduced.ConclusionBoth the general population and patients with PsA have experienced increasing rates of first arthroplasty from 1995 to 2010, although the overall incidence rate was significantly higher for those with PsA.
Short‐ or Long‐Term Treatment of Spinal Disability in Older Adults With Manipulation and Exercise
Authors: Maiers Michele , Hartvigsen Jan , Evans Roni , Westrom Kristine , Wang Qi , Schulz Craig , Leininger Brent , Bronfort Gert 
Published: October 2018

ObjectiveBack and neck pain are associated with disability and loss of independence in older adults. Whether long‐term management using commonly recommended treatments is superior to shorter‐term treatment is unknown. This randomized clinical trial compared short‐term treatment (12 weeks) versus long‐term management (36 weeks) of back‐ and neck‐related disability in older adults using spinal manipulative therapy (SMT) combined with supervised rehabilitative exercises (SRE).MethodsEligible participants were ages ≥65 years with back and neck disability for ≥12 weeks. Coprimary outcomes were changes in Oswestry Disability Index (ODI) and Neck Disability Index (NDI) scores after 36 weeks. An intent‐to‐treat approach used linear mixed‐model analysis to detect between‐group differences. Secondary analyses included other self‐reported outcomes, adverse events, and objective functional measures.ResultsA total of 182 participants were randomized. The short‐term and long‐term groups demonstrated significant improvements in back disability (ODI score –3.9 [95% confidence interval (95% CI) –5.8, –2.0] versus ODI score –6.3 [95% CI –8.2, –4.4]) and neck disability (NDI score –7.3 [95% CI –9.1, –5.5] versus NDI score –9.0 [95% CI –10.8, –7.2]) after 36 weeks, with no difference between groups (back ODI score 2.4 [95% CI –0.3, 5.1]; neck NDI score 1.7 [95% CI 0.8, 4.2]). The long‐term management group experienced greater improvement in neck pain at week 36, in self‐efficacy at weeks 36 and 52, and in functional ability, and balance.ConclusionFor older adults with chronic back and neck disability, extending management with SMT and SRE from 12 to 36 weeks did not result in any additional important reduction in disability.
Co2P–CoN Double Active Centers Confined in N‐Doped Carbon Nanotube: Heterostructural Engineering for Trifunctional Catalysis toward HER, ORR, OER, and Zn–Air Batteries Driven Water Splitting
Authors: Guo Yingying , Yuan Pengfei , Zhang Jianan , Xia Huicong , Cheng Fangyi , Zhou Mengfan , Li Jin , Qiao Yueyang , Mu Shichun , Xu Qun 
Published: October 2018

AbstractDeveloping active, robust, and nonprecious electrocatalysts for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) is highly crucial and challenging. In this work, a facile strategy is developed for scalable fabrication of dicobalt phosphide (Co2P)–cobalt nitride (CoN) core–shell nanoparticles with double active sites encapsulated in nitrogen‐doped carbon nanotubes (Co2P/CoN‐in‐NCNTs) by straight forward pyrolysis method. Both density functional theory calculation and experimental results reveal that pyrrole nitrogen coupled with Co2P is the most active one for HER, while Co–N–C active sites existing on the interfaces between CoN and N‐doped carbon shells are responsible for the ORR and OER activity in this catalyst. Furthermore, liquid‐state and all‐solid‐state Zn–air batteries are equipped. Co2P/CoN‐in‐NCNTs show high power density as high as 194.6 mW cm−2, high gravimetric energy density of 844.5 W h kg−1, very low charge–discharge polarization, and excellent reversibility of 96 h at 5 mA cm−2 in liquid system. Moreover, the Co2P/CoN‐in‐NCNTs profiles confirm excellent activity for water splitting.
Aerosol‐Jet Printed Fine‐Featured Triboelectric Sensors for Motion Sensing
Authors: Jing Qingshen , Choi Yeon Sik , Smith Michael , Ćatić Nordin , Ou Canlin , Kar‐Narayan Sohini 
Published: October 2018

AbstractTriboelectric motion sensors, based on the generation of a voltage across two dissimilar materials sliding across each other as a result of the triboelectric effect, have generated interest due to the relative simplicity of the typical grated device structures and materials required. However, these sensors are often limited by poor spatial and/or temporal resolution of motion due to limitations in achieving the required device feature sizes through conventional lithography or printing techniques. Furthermore, the reliance on metallic components that are relatively straightforward to pattern into fine features limits the possibility to develop transparent sensors. Polymers would allow for transparent devices, but these materials are significantly more difficult to pattern into fine features when compared to metals. Here, an aerosol‐jet printing (AJP) technique is used to develop triboelectric sensors using a wide variety of materials, including polymers, which can be directly printed into finely featured grated structures for enhanced sensitivity to displacement and speed of motion. A detailed investigation is presented highlighting the role of material selection and feature size in determining the overall resolution of the resulting motion sensor. A three‐channel rotary sensor is also presented, demonstrating the versatility of the AJP technique in developing more complex triboelectric motion sensors.
Chiral Brønsted Acid and Gold Catalyzed Enantioselective Synthesis of 1,8‐Dihydroindeno[2,1‐b]pyrroles
Authors: Jin Jianwen , Zhao Yichao , Sze Ella Min Ling , Kothandaraman Prasath , Chan Philip Wai Hong 
Published: October 2018

AbstractAn enantioselective synthetic method for the preparation of 1,8‐dihydroindeno[2,1‐b]pyrroles that relies on the chiral Brønsted acid‐ and gold(I)‐catalyzed dehydrative Nazarov‐type electrocyclization (DNE)/hydroamination of electron‐rich β‐amino‐1,4‐enyols is described. Achieved in product yields up to 99% and enantiomeric excess (ee) values up to 99%, the asymmetric reaction provides access to a novel class of compounds containing both the privileged 1H‐indene and pyrrole scaffold, which may lead to novel pharmacological applications.magnified image
Valve‐Enabled Sample Preparation and RNA Amplification in a Coffee Mug for Zika Virus Detection
Authors: Jiang Xiao , Loeb Julia C. , Manzanas Carlos , Lednicky John A. , Fan Z. Hugh 
Published: October 2018

AbstractThe recent outbreaks of Zika virus (ZIKV) infection represent a public health challenge. Rapid, cost‐effective, and reliable diagnostic tools for ZIKV detection at the point of care (POC) are highly desirable, especially for resource‐limited nations. To address the need, we have developed an integrated device to achieve sample‐to‐answer ZIKV detection. The device features innovative ball‐based valves enabling the storage and sequential delivery of reagents for virus lysis and a paper‐based unit for RNA enrichment and purification. The paper unit is placed in a commercially available coffee mug that provides a constant temperature for reverse transcription loop‐mediated isothermal amplification (RT‐LAMP), followed by colorimetric detection by naked eye or a cellphone camera. Using the device, we demonstrated the reproducible detection of ZIKV in human urine and saliva samples.
gem‐Difluorination of Alkenyl N‐methyliminodiacetyl Boronates: Synthesis of α‐ and β‐Difluorinated Alkylborons
Authors: Lv Wen‐Xin , Li Qingjiang , Li Ji‐Lin , Li Zhan , Lin E , Tan Dong‐Hang , Cai Yuan‐Hong , Fan Wen‐Xin , Wang Honggen 
Published: October 2018

AbstractOrganofluorine compounds are widely used in pharmaceutical, agrochemical, and materials sciences. The syntheses and applications of fluorinated organoborons facilitate the rapid and modular assemblies of fluorine‐containing molecules because of the versatility of C−B bonds in diverse chemical transformations. Reported herein is a migratory geminal difluorination of aryl‐substituted alkenyl N‐methyliminodiacetyl (MIDA) boronates using commercially available Py⋅HF as the fluorine source and hyperiodine as the oxidant. The protocol offers facile access to α‐ and β‐difluorinated alkylboron compounds, both of which have previously been challenging to prepare. Mild reaction conditions, broad substrate scope, good functional‐group tolerance, and moderate to good yields were observed. The utility of these products is demonstrated by further transformations of the C−B bond into other valuable functional groups.
Aerobic Baeyer–Villiger Oxidation Catalyzed by a Flavin‐Containing Enzyme Mimic in Water
Authors: Chevalier Yoan , Lock Toy Ki Yvette , le Nouen Didier , Mahy Jean‐Pierre , Goddard Jean‐Philippe , Avenier Frédéric 
Published: October 2018

AbstractDirect incorporation of molecular oxygen into small organic molecules has attracted much attention for the development of new environmentally friendly oxidation processes. In line with this approach, bioinspired systems mimicking enzyme activities are of particular interest since they may perform catalysis in aqueous media. Demonstrated herein is the incorporation of a natural flavin cofactor (FMN) into the specific microenvironment of a water‐soluble polymer which allows the efficient reduction of the FMN by NADH in aqueous solution. Once reduced, this artificial flavoenzyme can then activate molecular dioxygen under aerobic conditions and result in the Baeyer–Villiger reaction at room temperature in water.
Literacy practices of primary education children in Andalusia (Spain): A family‐based perspective
Authors: Moreno‐Morilla Celia , Guzmán‐Simón Fernando , García‐Jiménez Eduardo 
Published: October 2018

Primary school children develop literacy practices in various domains and situations in everyday life. This study focused on the analysis of literacy practices of children aged 8–12 years from the perspective of their families. 1,843 families participated in the non‐experimental explanatory study. The children in these families speak Spanish as a first language and are schooled in this language. The instrument used was a self‐report questionnaire about children's home‐literacy practices. The data obtained were analysed using categorical principal components analysis (CATPCA) and analysis of variance (ANOVA). The results show the complex relationship between literacy practices developed by children in the domains of home and school and the limited development of a literacy‐promoting ‘third space’. In conclusion, the families in our study had limited awareness of their role as literacy‐promoting agents and thought of literacy learning as restricted to formal or academic spaces.
A comparison of model selection methods for prediction in the presence of multiply imputed data
Authors: Thao Le Thi Phuong , Geskus Ronald 
Published: October 2018

AbstractMany approaches for variable selection with multiply imputed data in the development of a prognostic model have been proposed. However, no method prevails as uniformly best. We conducted a simulation study with a binary outcome and a logistic regression model to compare two classes of variable selection methods in the presence of MI data: (I) Model selection on bootstrap data, using backward elimination based on AIC or lasso, and fit the final model based on the most frequently (e.g. ) selected variables over all MI and bootstrap data sets; (II) Model selection on original MI data, using lasso. The final model is obtained by (i) averaging estimates of variables that were selected in any MI data set or (ii) in 50% of the MI data; (iii) performing lasso on the stacked MI data, and (iv) as in (iii) but using individual weights as determined by the fraction of missingness. In all lasso models, we used both the optimal penalty and the 1‐se rule. We considered recalibrating models to correct for overshrinkage due to the suboptimal penalty by refitting the linear predictor or all individual variables. We applied the methods on a real dataset of 951 adult patients with tuberculous meningitis to predict mortality within nine months. Overall, applying lasso selection with the 1‐se penalty shows the best performance, both in approach I and II. Stacking MI data is an attractive approach because it does not require choosing a selection threshold when combining results from separate MI data sets
Correct and logical inference on efficacy in subgroups and their mixture for binary outcomes
Authors: Lin Hui‐Min , Xu Haiyan , Ding Ying , Hsu Jason C. 
Published: October 2018

AbstractTargeted therapies are becoming more common. In targeted therapy development, suppose its companion diagnostic test divides patients into a marker‐positive subgroup and its complementary marker‐negative subgroup. To find the right patient population for the therapy to target, inference on efficacy in the marker‐positive and marker‐negative subgroups as well as efficacy in the overall mixture population are all of interest. Depending on the type of clinical endpoints, inference on mixture population can be nontrivial and commonly used efficacy measures may not be suitable for a mixture population. Correlations among estimates of efficacy in the marker‐positive, marker‐negative, and overall mixture population play a crucial role in using an earlier phase study to inform on the design of a confirmatory study (e.g., determination of sample size). This article first shows that when the clinical endpoint is binary (such as respond or not), odds ratio is inappropriate as an efficacy measure in this setting, but relative response (RR) is appropriate. We show a safe way of calculating estimated correlations is to consider mixing subgroup response probabilities within each treatment arm first, and then derive the joint distribution of RR estimates. We also show, if one calculates RR within each subgroup first, how wrong the correlations can be if the Delta method derivation fails to take randomness of estimating the mixing coefficient into account.
Diffusion-weighted MRI assessment of the peritoneal cancer index before cytoreductive surgery
Authors: van't Sant I , van Eden W J , Engbersen M P , Kok N F M , Woensdregt K , Lambregts D M J , Shanmuganathan S , Beets-Tan R G H , Aalbers A G J , Lahaye M J 
Published: October 2018

Abstract

Background
Patients with limited peritoneal metastases from colorectal cancer may be candidates for an aggressive surgical approach including cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS–HIPEC). Selection is based on surgical inspection during laparoscopy or laparotomy. The aim of this study was to investigate whether diffusion-weighted MRI (DW-MRI) can be used to select patients for CRS–HIPEC.

Methods
This was a prospective study at a tertiary referral centre. Patients with confirmed or suspected colorectal peritoneal metastases scheduled for exploratory laparotomy or laparoscopy were eligible. Two radiologists assessed the peritoneal cancer index (PCI) on CT (CT-PCI) and DW-MRI (MRI-PCI). The reference standard was PCI at surgery. Radiologists were blinded to the surgical PCI and to each other's findings. The main outcome was the accuracy of DW-MRI in predicting whether patients had resectable disease (PCI less than 21) or not.

Results
Fifty-six patients were included in the study, of whom 49 could be evaluated. The mean(s.d.) PCI at surgery was 11·27(7·53). The mean MRI-PCI was 10·18(7·07) for reader 1 and 8·59(7·08) for reader 2. Readers 1 and 2 correctly staged 47 of 49 and 44 of 49 patients respectively (accuracy 96 and 90 per cent). Both readers detected all patients with resectable disease with a PCI below 21 at surgery (sensitivity 100 per cent). No patient was overstaged. The intraclass correlation (ICC) between readers was excellent (ICC 0·91, 95 per cent c.i. 0·77 to 0·96). MRI-PCI had a stronger correlation with surgical PCI (ICC 0·83–0·88) than did CT-PCI (ICC 0·39–0·44).

Conclusion
DW-MRI is a promising non-invasive tool to guide treatment selection in patients with peritoneal metastases from colorectal cancer.
A FPGA‐based experimentation system for designing, implementing, and evaluating real‐time video processing and analysis algorithms at undergraduate level
Authors: Garcia Ivan , Guzmán‐Ramírez Enrique 
Published: October 2018

AbstractReal‐time digital video processing is an important area for students on computer and electronic engineering courses who have to learn how to design efficient applications required for industry, such as autonomous navigation, automatic detection and recognition of objects, autonomous process supervision, etc. Nevertheless, the computational complexity and large amount of data access within real‐time video processing have resulted in the need for alternative learning environments that facilitate this task. This paper aims to introduce a FPGA‐based system into traditional classrooms to promote experimentation when designing, implementing, and evaluating real‐time video processing and analysis algorithms at undergraduate level. With the aim of evaluating the system proposed in this paper, fourth‐year Computer and Electronic Engineering students performed various real‐time video processing and analysis experiments to effectively design robust algorithms. A qualitative research method identified positive student perceptions that might lead to improved technical skills.
Aberrant CpG‐methylation affects genes expression predicting survival in lung adenocarcinoma
Authors: He Wei , Ju Dandan , Jie Zhijun , Zhang Ai , Xing Xin , Yang Qin 
Published: October 2018

AbstractLung adenocarcinoma (LUAD) is a common diagnosed disease with high‐mortality rate, and its prognostic implications are under discovered. DNA methylation aberrations are not only an important event for dysregulation of gene expression during tumorigenesis but also a revolution in epigenetics by identifying key prognostic biomarkers for multiple cancers. In this study, we analyzed methylation status of 485 578 CpG sites and RNA‐seq transcriptomes of 20 532 genes for 1095 LUAD samples in TCGA database. The association between DNA methylation and the prognostic value of the corresponding gene expression was identified as well. In total, ten aberrantly methylated and dysregulated genes (AURKA, BLK, CNTN2, HMGA1, PTTG1, TNS4, DAPK2, MFSD2A, THSD1, and WNT7A) were highlighted which were significantly correlated with overall survival of 492 LUAD patients, which were all reported as tumor‐associated genes in other various cancers and worthy of further investigated and might be used as therapeutic targets for LUAD. Together, methylation aberrances regulate gene expression level during tumorigenesis and influence prognosis of LUAD patients. Integrating knowledge of epigenetics and expression of genes can be useful for an in‐depth understanding of cancer mechanism and for the eventual purpose of precisely prognostic and therapeutic target verification.
Li3BN2 as a Transition Metal Free, High Capacity Cathode for Li‐ion Batteries
Authors: Emani Satyanarayana , Liu Caihong , Ashuri Maziar , Sahni Karan , Wu Jinpeng , Yang Wanli , Németh Károly , Shaw Leon L. 
Published: October 2018

AbstractLi3BN2 is investigated for the first time as a transition metal free, high capacity cathode material for Li‐ion batteries. It is shown that α‐Li3BN2 can exhibit a specific capacity of 890 mA h g−1 with the charge storage mechanism associated with the valence state change of N ions in the BN2 anion. The specific capacity demonstrated in this study is the highest one ever reported in literature for an intercalation‐type cathode material. Further, using the valence state change of N ions as a charge storage mechanism opens the door for designing additional high performance, transition metal free electrodes in the future.