bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of L-arginine supplementation on obesity-related indices: A systematic review and meta-analysis of randomized clinical trials
Authors: Mousavi Seyed Mohammad , Milajerdi Alireza , Fatahi Somaye , Rahmani Jamal , Zarezadeh Meysam , Ghaedi Ehsan , Varkaneh Hamed Kord 
Published: April 2019

Abstract. The clinical studies regarding the effect of L-arginine in human anthropometry have not been fully consistent, therefore, we carried out a systematic review and meta-analysis of randomized clinical trials in order to precisely evaluate and quantify the efficacy of L-arginine on weight, waist circumference, and BMI. We searched online databases including PubMed, SCOPUS, and Google Scholar for relevant articles up to September 2017. Eligible articles were reviewed by two independent investigators. Mean differences of the outcomes were used for calculation of weighted mean difference (WMD) derived from the random-effects model. Statistical heterogeneity between studies was examined using Cochran’s Q-test and I 2 index. Funnel plot and Egger’s tests were performed to assess the publication bias. In our initial search, we found 1598 publications, of which 8 RCTs (9 treatment arms) were included. The results of the meta-analysis displayed a significant reduction in WC following L-arginine supplementation (WMD: −2.97 cm; 95% CI: −4.75 to −1.18, P = 0.001). However, L-arginine intervention had not elicited a significant effect on BMI (WMD: −0.51 kg/m2; 95% CI: −1.11 to .08, P = 0.09) and body weight (WMD: −0.57 kg; 95% CI: −1.77 to 0.61, P = 0.34). Subgroup analyses displayed that longer-term interventions (≥8 weeks) had a positive effect on body weight and using < 8 g/day L-arginine with longer duration (≥8 weeks) could significantly decrease BMI. In conclusion, this meta-analysis result suggested L-arginine supplementation could reduce waist circumference without any significant effect on body weight and body mass index.
Synbiotic supplementation is not effective on breast milk selenium	concentrations and growth of exclusively breast fed infants: a pilot	study
Authors: Nikniaz Leila , Mahavi Reza , Ostadrahimi Alireza , Nikniaz Zeinab , Taghipour Sharare 
Published: April 2019

Abstract. In this randomized, double-blind, placebo-controlled trial, 57 lactating mothers were randomly allocated into two groups to receive a daily supplement of synbiotic (n = 30) which contained different probiotic strains (2.0 × 108 CFU) and fructooligosaccharide (394 mg) or a placebo (n = 27) for 30 days. Dietary intake was collected from lactating women by 24-hour recall method. Breast milk selenium contents were determined by atomic absorption spectrometry with graphite furnace. Weight for age Z-score (WAZ) and Height for age Z-score (HAZ) were evaluated for infants. Data analyses were assessed using nutritionist IV, Epi Info and SPSS software and presented as mean ± sd or SEM. The total mean breast milk selenium levels were 50.1 ± 16.1 mcg L−1. At the baseline, the mean breast milk selenium concentrations in the synbiotic and placebo groups were 51.7 ± 20.2 and 48.5 ± 12.1 mcg L−1. The mean breast milk selenium levels increased and decreased in the symbiotic and placebo groups respectively, which were not significant (p > 0.05). Also, comparison of the changes in breast milk selenium concentration showed no significant difference between the two study groups after the intervention. At the baseline, the mean WAZ and HAZ of infants whose mothers’ milk selenium was more than 60 mcg/l was significantly (P < 0.05) higher than for others. In this pilot study, no significant effect was observed by synbiotic supplementation, however, for concise conclusion, more human studies with higher doses of supplements and longer duration of supplementation are needed to determine the effects of synbiotic supplementation on breast milk selenium contents and infants’ growth.
The Response of Permafrost and High‐Latitude Ecosystems Under Large‐Scale Stratospheric Aerosol Injection and Its Termination
Authors: Lee Hanna , Ekici Altug , Tjiputra Jerry , Muri Helene , Chadburn Sarah E. , Lawrence David M. , Schwinger Jörg 
Published: April 2019

AbstractClimate engineering arises as one of the potential methods that could contribute to meeting the 1.5 °C global warming target agreed under the Paris Agreement. We examine how permafrost and high‐latitude vegetation respond to the large‐scale implementation of climate engineering. Specifically, we explore the impacts of applying the solar radiation management method of stratospheric aerosol injections (SAI) on permafrost temperature and the global extent of near‐surface permafrost area. We compare the RCP8.5 and RCP4.5 scenarios to several SAI deployment scenarios using the Norwegian Earth System Model (CE1 = moderate SAI scenario to bring down the global mean warming in RCP8.5 to the RCP4.5 level, CE2 = aggresive SAI scenario to maintain the global mean temperature toward the preindustrial level). We show that large‐scale application of SAI may help slow down the current rate of permafrost degradation for a wide range of emission scenarios. Between the RCP4.5 and CE1 simulations, the differences in the permafrost degradation may be attributed to the spatial variations in surface air temperature, rainfall, and snowfall, which lead to the differences in the timing of permafrost degradation up to 40 years. Although atmospheric temperatures in CE1 and RCP4.5 simulations are similar, net primary production is higher in CE1 due to CO2 fertilization. Our investigation of permafrost extent under large‐scale SAI application scenarios suggests that circum‐Arctic permafrost area and extent is rather sensitive to temperature changes created under such SAI application. Our results highlight the importance of investigating the regional effects of climate engineering, particularly in high‐latitude ecosystems.
Dynamical Coupling Between Hurricane Matthew and the Middle to Upper Atmosphere via Gravity Waves
Authors: Xu Shuang , Yue Jia , Xue Xianghui , Vadas Sharon L. , Miller Steven D. , Azeem Irfan , Straka William , Hoffmann Lars , Zhang Simin 
Published: April 2019

AbstractDuring 30 September to 9 October 2016, Hurricane Matthew traversed the Caribbean Sea to the east coast of the United States. During its period of greatest intensity, in the central Caribbean, Matthew excited a large number of concentric gravity waves (GWs or CGWs). In this paper, we report on hurricane‐generated CGWs observed in both the stratosphere and mesosphere from spaceborne satellites and in the ionosphere by ground Global Positioning System receivers. We found CGWs with horizontal wavelengths of ~200–300 km in the stratosphere (height of ~30–40 km) and in the airglow layer of the mesopause (height of ~85–90 km), and we found concentric traveling ionospheric disturbances (TIDs or CTIDs) with horizontal wavelengths of ~250–350 km in the ionosphere (height of ~100–400 km). The observed TIDs lasted for more than several hours on 1, 2, and 7 October 2016. We also briefly discuss the vertical and horizontal propagation of the Hurricane Matthew‐induced GWs and TIDs. This study shows that Hurricane Matthew induced significant dynamical coupling between the troposphere and the entire middle and upper atmosphere via GWs. It is the first comprehensive satellite analysis of gravity wave propagation generated by hurricane event from the troposphere through the stratosphere and mesosphere into the ionosphere.
Statistical Postprocessing of Water Level Forecasts Using Bayesian Model Averaging With Doubly Truncated Normal Components
Authors: Baran Sándor , Hemri Stephan , El Ayari Mehrez 
Published: April 2019

AbstractAccurate and reliable probabilistic forecasts of hydrological quantities like runoff or water level are beneficial to various areas of society. Probabilistic state‐of‐the‐art hydrological ensemble prediction models are usually driven with meteorological ensemble forecasts. Hence, biases and dispersion errors of the meteorological forecasts cascade down to the hydrological predictions and add to the errors of the hydrological models. The systematic parts of these errors can be reduced by applying statistical postprocessing. For a sound estimation of predictive uncertainty and an optimal correction of systematic errors, statistical postprocessing methods should be tailored to the particular forecast variable at hand. Former studies have shown that it can make sense to treat hydrological quantities as bounded variables. In this paper, a doubly truncated Bayesian model averaging (BMA) method, which allows for flexible postprocessing of possibly multimodel ensemble forecasts of water level, is introduced. A case study based on water levels for a gauge of river Rhine reveals a good predictive skill of doubly truncated BMA compared both to the raw ensemble and the reference ensemble model output statistics approach. Using rolling training periods, BMA considerably outerperforms ensemble model output statistics. However, this gap shrinks drastically when using analog‐based training periods.
The Magnetic Signatures of the M2, N2, and O1 Oceanic Tides Observed in Swarm and CHAMP Satellite Magnetic Data
Authors: Grayver Alexander V. , Olsen Nils 
Published: April 2019

AbstractThis paper reports on new results in the determination of magnetic signals produced by oceanic tides as estimated from satellite magnetic measurements. We find that combining data from the past CHAMP (2000–2010) and the present Swarm (since 2013) satellite missions significantly improves the quality of the extracted tidal signals, in particular if along‐track and cross‐track magnetic “gradient” data are utilized. This allows us to determine the magnetic signature not only of the M2 tide but also of the much weaker N2 and O1 tidal constituents. To minimize disturbances from magnetospheric and ionospheric currents, we only use data from the nightside region during geomagnetic quiet conditions and remove core, crustal, and magnetospheric field contributions as given by the CHAOS geomagnetic field model. Despite their small magnitudes, all determined tidal constituents show sensitivity to the electrical conductivity profile of the underlying mantle, enabling imaging the upper mantle below the oceans.
Assessment of pain symptoms and quality of life using the International Spinal Cord Injury Data Sets in persons with chronic spinal cord injury
Authors: Gibbs Katie , Beaufort Andrew , Stein Adam , Leung Tung Ming , Sison Cristina , Bloom Ona 
Published: April 2019

Abstract
Introduction
Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI.

Study design
Prospective observational pilot study.

Objectives
To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI.

Setting
Academic medical center, New York, USA.

Methods
The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with chronic SCI (N = 31) at 2 study visits held 6 months apart. The QoL Data Set was also used to collect data from able-bodied persons of similar age and gender distribution (N = 28).

Results
Most participants with SCI had multiple types and locations of pain problems at both study visits, despite reported being treated for pain. At both visits, the worst pain problem type was nociceptive, followed by neuropathic, which was typically rated of higher intensity. QoL scores were significantly lower across all domains of the data set in persons with SCI than able-bodied persons. Persons with pain tended to have lower QoL scores, although this trend was not significant.

Conclusions
This study demonstrates the presence, complexity and stability of pain symptoms refractory to treatment and lower quality of life ratings in persons with chronic SCI.

Sponsorship
Grants from the Craig H. Neilsen Foundation, New York Empire Clinical Research Program, New York State Spinal Cord Injury Research Board.
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways
Authors: Feng Xue , Yan Naimeng , Sun Weibin , Zheng Shanliang , Jiang Sixiong , Wang Jinxia , Guo Chunmei , Hao Lihong , Tian Yuxiang , Liu Shuqing , Sun Ming-Zhong 
Published: April 2019

AbstractClear cell renal cell carcinoma (ccRCC) is the most aggressive RCC subtype with high metastasis, chemotherapy and radiotherapy resistance, and poor prognosis. This study attempted to establish the deregulations of miR-4521 and FAM129A together with their correlation to and mechanism of regulation of ccRCC development and progression. FAM129A acted as tumor promotor and miR-4521 acted as a suppressor in ccRCC. As measured in surgical tumorous tissues from ccRCC patients, FAM129A overexpression and miR-4521 deficiency together contributed to ccRCC progression by promoting advances in patients’ TNM stage and Fuhrman grade. Both the FAM129A knockdown and miR-4521 overexpression could reduce the in vitro migration and invasion abilities of renal cancer cells 786-O and ACHN, through the TIMP-1/MMP2/MMP9 pathway and could decrease their proliferation by promoting their apoptosis through the MDM2/p53/Bcl2/Bax pathway. By directly targeting the 3′-UTR domain ofFAM129A, miR-4521 was negatively correlated withFAM129A/FAM129A levels in ccRCC progression and renal cancer cell malignancies. This work establishes the miR-4521-FAM129A axial regulation mechanism in ccRCC. Micro-4521 deficiency leads toFAM129A/FAM129A upregulation, which synergistically enhances the migration and invasion of renal cancer cells due to the induced decrease of TIMP-1 and increases of MMP2 and MMP9, and increases their growth through escaping apoptosis by suppressing p53 by way of upregulation of induced MDM2. The current work provides new clues to assist fundamental research into the diagnosis and treatment of ccRCC.
Centromere mechanical maturation during mammalian cell mitosis
Authors: Harasymiw Lauren A. , Tank Damien , McClellan Mark , Panigrahy Neha , Gardner Melissa K. 
Published: April 2019

AbstractDuring mitosis, tension develops across the centromere as a result of spindle-based forces. Metaphase tension may be critical in preventing mitotic chromosome segregation errors, however, the nature of force transmission at the centromere and the role of centromere mechanics in controlling metaphase tension remains unknown. We combined quantitative, biophysical microscopy with computational analysis to elucidate the mechanics of the centromere in unperturbed, mitotic human cells. We discovered that the mechanical stiffness of the human centromere matures during mitotic progression, which leads to amplified centromere tension specifically at metaphase. Centromere mechanical maturation is disrupted across multiple aneuploid cell lines, leading to a weak metaphase tension signal. Further, increasing deficiencies in centromere mechanical maturation are correlated with rising frequencies of lagging, merotelic chromosomes in anaphase, leading to segregation defects at telophase. Thus, we reveal a centromere maturation process that may be critical to the fidelity of chromosome segregation during mitosis.
QUIRKY regulates root epidermal cell patterning through stabilizing SCRAMBLED to control CAPRICE movement in Arabidopsis
Authors: Song Jae Hyo , Kwak Su-Hwan , Nam Kyoung Hee , Schiefelbein John , Lee Myeong Min 
Published: April 2019

AbstractSCM, a leucine-rich repeat receptor-like kinase, is required for root epidermal cells to appropriately interpret their location and generate the proper cell-type pattern during Arabidopsis root development. Here, via a screen for scm-like mutants we describe a new allele of the QKY gene. We find that QKY is required for the appropriate spatial expression of several epidermal cell fate regulators in a similar manner as SCM in roots, and that QKY and SCM are necessary for the efficient movement of CPC between epidermal cells. We also show that turnover of SCM is mediated by a vacuolar degradation pathway triggered by ubiquitination, and that QKY prevents this SCM ubiquitination through their physical interaction. These results suggest that QKY stabilizes SCM through interaction, and this complex facilitates CPC movement between the epidermal cells to help establish the cell-type pattern in the Arabidopsis root epidermis.
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Authors: Wong Hoi Leong Xavier , Qin Hong-yan , Tsang Siu Wai , Zuo Xiao , Che Sijia , Chow Chi Fung Willis , Li Xi , Xiao Hai-tao , Zhao Ling , Huang Tao , Lin Cheng Yuan , Kwan Hiu Yee , Yang Tao , Longo Frank M. , Lyu Aiping , Bian Zhao-xiang 
Published: April 2019

AbstractEarly childhood is a critical period for development, and early life stress may increase the risk of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal maternal separation (NMS) induces bowel dysfunctions that resemble IBS. However, the underlying mechanisms remain unclear. Here we show that NMS induces expansion of intestinal stem cells (ISCs) and their differentiation toward secretory lineages including enterochromaffin (EC) and Paneth cells, leading to EC hyperplasia, increased serotonin production, and visceral hyperalgesia. This is reversed by inhibition of nerve growth factor (NGF)-mediated tropomyosin receptor kinase A (TrkA) signalling, and treatment with NGF recapitulates the intestinal phenotype of NMS mice in vivo and in mouse intestinal organoids in vitro. Mechanistically, NGF transactivates Wnt/β-catenin signalling. NGF and serotonin are positively correlated in the sera of diarrhea-predominant IBS patients. Together, our findings provide mechanistic insights into early life stress-induced intestinal changes that may translate into treatments for gastrointestinal diseases.
The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model
Authors: Zhou Muran , Hou Jinfei , Li Yuan , Mou Shan , Wang Zhenxing , Horch Raymund E. , Sun Jiaming , Yuan Quan 
Published: April 2019

AbstractTissue engineering is a promising technology used as an alternative to organ/tissue transplantation which is often limited by donor shortage. The construction of large-sized engineered tissue requires a fast and sufficient vascularization process. Previous studies have shown that hypoxia-inducible factor (HIF) -1α may promote the vascularization process implying that stabilized HIF-1α can be applied in the engineering of large-sized tissue. However, the toxicity and off-target effect of previously reported HIF-1α stabilizers limit their clinical application. FG-4592, a small molecule specific HIF stabilizer, was previously investigated as an anti-anemia drug in a phase-III clinical trial. Here we found that FG-4592 promoted tube formation in an in vitro model of angiogenesis by stabilizing HIF-1α and activating vascular endothelial growth factor (VEGF). When FG-4592 immobilized fibrin gel scaffold was implanted into a subcutaneous tissue engineering chamber, the vascularization process was significantly enhanced through the similar mechanisms which was verified in vitro. We conclude that FG-4592 may serve as a pro-angiogenic molecule for the construction of large-sized engineered tissue where intensive angiogenesis is required.
Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells
Authors: Civiletti Federica , Assenzio Barbara , Mazzeo Anna Teresa , Medica Davide , Giaretta Fulvia , Deambrosis Ilaria , Fanelli Vito , Ranieri Vito Marco , Cantaluppi Vincenzo , Mascia Luciana 
Published: April 2019

AbstractAcute kidney injury following traumatic brain injury is associated with poor outcome. We investigatedin vitrothe effects of plasma of brain injured patients with acute tubular kidney injury on kidney tubular epithelial cell function. we performed a prospective observational clinical study in ICU in a trauma centre of the University hospital in Italy including twenty-three ICU patients with traumatic brain injury consecutively enrolled. Demographic data were recorded on admission: age 39 ± 19, Glasgow Coma Score 5 (3–8). Neutrophil Gelatinase-Associated Lipocalin and inflammatory mediators were measured in plasma on admission and after 24, 48 and 72 hours; urine were collected for immunoelectrophoresis having healthy volunteers as controls. Human renal proximal tubular epithelial cells were stimulated with patients or controls plasma. Adhesion of freshly isolated human neutrophils and trans-epithelial electrical resistance were assessed; cell viability (XTT assay), apoptosis (TUNEL staining), Neutrophil Gelatinase-Associated Lipocalin and Megalin expression (quantitative real-time PCR) were measured. All patients with normal serum creatinine showed increased plasmatic Neutrophil Gelatinase-Associated Lipocalin and increased urinary Retinol Binding Protein and α1-microglobulin. Neutrophil Gelatinase-Associated Lipocalin was significantly correlated with both inflammatory mediators and markers of tubular damage. Patient’ plasma incubated with tubular cells significantly increased adhesion of neutrophils, reduced trans-epithelial electrical resistance, exerted a cytotoxic effect and triggered apoptosis and down-regulated the endocytic receptor Megalin compared to control. Plasma of brain injured patients with increased markers of subclinical acute kidney induced a pro-inflammatory phenotype, cellular dysfunction and apoptotic death in tubular epithelial cells.
Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study
Authors: Hirabayashi Mayo , Inoue Manami , Sawada Norie , Saito Eiko , Abe Sarah K. , Hidaka Akihisa , Iwasaki Motoki , Yamaji Taiki , Shimazu Taichi , Tsugane Shoichiro 
Published: April 2019

AbstractHelicobacter pylori (H. pylori), an established risk factor for gastric cancer, is suggested to also play a role in the development of pancreatic cancer; however, the association remains inconclusive. We examined this association among Japanese men and women. H. pylori and atrophic gastritis (AG) status were determined serologically, using blood sample collected during health checkups. A total of 20,116 subjects enrolled in the Japan Public Health Center-based Prospective Study Cohort II with available data on H. pylori seropositivity (anti-H. pylori) and AG were followed until the end of 2010. Cox proportional hazards models were used to calculate the hazard ratios (HR) and 95% confidence intervals (CI), using the information from the baseline survey. During 320,470 person-years of follow-up, 119 cases of pancreatic cancer were identified. No statically significant increase or decrease in pancreatic cancer risk was observed for H. pylori and AG status, independently or in combination. In a multivariable-adjusted model, we observed a non-significant decrease in the risk among those who had AG but were anti-H. pylori seronegative (HR 0.57, 95% CI 0.31–1.03). In a stratified analysis, we observed a statistically significant increased risk of pancreatic cancer for AG+ (HR 3.64, 95% CI 1.37–9.66), and AG+/anti-H. pylori− or AG+/anti-H. pylori+ (HR 5.21, 95% CI 1.14–23.87) among current smokers. Non-smokers in all categories of AG and anti-H. pylori showed a non-statistical decrease in the risk. There was no statistically significant interaction between H. pylori infection, AG status, and smoking status. Our findings suggest H. pylori seropositivity and AG, individually or in combination, are not associated with the risk of pancreatic cancer in a general Japanese population. Among current smokers, pancreatic cancer risk increased with AG, regardless of H. pylori infection status.