bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between condylar height relative to occlusal plane and condylar osseous condition and TMJ loading based on 3D measurements and finite element analysis
Authors: Gong Yanji , Zhu Jinyi , Zheng Fangjie , Zhu Yunfan , Sui Shangyan , Liu Yang , Yin Deqiang 
Published: November 2024

AbstractTo investigate the relationship between condylar height relative to occlusal plane (CHO) and condylar osseous condition and the changes of condylar stress loading before and after CHO modifications. The condylar osseous conditions of 434 temporomandibular joints (TMJ) were assessed and grouped. Measurements of anatomical parameters were performed on CT-based reconstructed 3D stomatognathic models. Differences in anatomical parameters of the jaws in the different groups were compared, and the correlation between the Angle α (representing the CHO ratio) and related parameters was investigated. A finite element model (FEM) was constructed using 3D finite element analysis (FEA). The Angle α was altered by modifying condylar position and the inclination of mandibular plane (MP) and occlusal plane (OP) based on the FEM to analyze condylar stress loading under different working conditions. There were differences in anatomical parameters among the different groups, with the smaller Angle α in the osseous destruction group. Angle α was negatively correlated with the inclination of MP and OP. The FEA illustrated condylar stress loading changed after modifying the Angle α by both two modalities. After modifying condylar position, the stress increased with the proximal movement of the condyle toward the OP. After changing the inclination of MP and OP, the stress increased with increasing inclinations. Changes in CHO correlate with condylar osseous condition, and distal movement of the condyle to the OP and reduction of MP and OP inclination may reduce TMJ stress overload. In clinical practice, it is advisable to assess patients for sufficient CHO ratio, as insufficiency in CHO may elevate the risk of TMJ stress overload. The CHO ratio could be modulated by changing the inclination of the OP.
The optimal formulation of a readily compostable horticultural growing substrate for vertical farming was determined using design of experiments
Authors: Romo Jonathan M. , Smith Isabel N. , Galloway Michael , Cuthbertson Timothy J. 
Published: November 2024

AbstractA novel, optimized, polysaccharide and biochar-based, compostable hydrogel horticultural growing substrate for use in hydroponics and vertical farming was created based upon empirical methods and statistical design of experiments. A 15-run D-optimal mixture design of experiments was completed that increased the 14-day plant growing ability of a five-component hydrogel nearly ten-fold from 4.3695 g to 41.2623 g per 100 plants. The data were analyzed using a standard least squares method with an effect screening emphasis, and a model was created that maximized the signal to noise ratio. There was a good correlation between the measured and predicted values of the model, with an r-squared value of 0.90. The predictions of efficacy and compostability were confirmed with subsequent experiments that showed the hydrogel was composted in less than 84 days and that the plant growth predicted by the model differed from the experimental growth by 0.65%. The resulting optimized formulation had a high fertilizer content for a growth medium. We therefore suggest that an empirical approach to formulation research can produce superior outcomes with a statistically designed study.
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome
Authors: Pan Hui , Tian Ai-Ling , Chen Hui , Xia Yifan , Sauvat Allan , Moriceau Stephanie , Lambertucci Flavia , Motiño Omar , Zhao Liwei , Liu Peng , Mao Misha , Li Sijing , Zhang Shuai , Joseph Adrien , Durand Sylvère , Aprahamian Fanny , Luo Zeyu , Ou Yang , Shen Zhe , Xue Enfu , Pan Yuhong , Carbonnier Vincent , Stoll Gautier , Forveille Sabrina , Leduc Marion , Cerrato Giulia , Cerone Alexandra , Maiuri Maria Chiara , Castinetti Frederic , Brue Thierry , Wang Hongsheng , Ma Yuting , Martins Isabelle , Kepp Oliver , Kroemer Guido 
Published: November 2024

AbstractCushing’s syndrome is caused by an elevation of endogenous or pharmacologically administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the gene diazepam binding inhibitor, Dbi) stimulates food intake and lipo-anabolic reactions. Here we found that plasma ACBP/DBI concentrations were elevated in patients and mice with Cushing’s syndrome. We used several methods for ACBP/DBI inhibition in mice, namely, (1) induction of ACBP/DBI autoantibodies, (2) injection of a neutralizing monoclonal antibody, (3) body-wide or hepatocyte-specific knockout of the Dbi gene, (4) mutation of the ACBP/DBI receptor Gabrg2 and (5) injections of triiodothyronine or (6) the thyroid hormone receptor-β agonist resmetirom to block Dbi transcription. These six approaches abolished manifestations of Cushing’s syndrome such as increased food intake, weight gain, excessive adiposity, liver damage, hypertriglyceridaemia and type 2 diabetes. In conclusion, it appears that ACBP/DBI constitutes an actionable target that is causally involved in the development of Cushing’s syndrome.
Seasonality and climate modes influence the temporal clustering of unique atmospheric rivers in the Western U.S
Authors: Yang Zhiqi , DeFlorio Michael J. , Sengupta Agniv , Wang Jiabao , Castellano Christopher M. , Gershunov Alexander , Guirguis Kristen , Slinskey Emily , Guan Bin , Delle Monache Luca , Ralph F. Martin 
Published: November 2024

AbstractAtmospheric rivers (ARs) are narrow corridors of intense water vapor transport, shaping precipitation, floods, and economies. Temporal clustering of ARs tripled losses compared to isolated events, yet the reasons behind this clustering remain unclear. AR orientation further modulates hydrological impacts through terrain interaction. Here we identify unique ARs over the North Pacific and Western U.S. and utilize Cox regression and composite analysis to examine how six major climate modes influence temporal clustering of unique ARs and orientation during extended boreal winter (November to March). Results show that climate modes condition temporal clustering of unique ARs. The Pacific-North American weather pattern strongly modulates the clustering over the Western U.S. from early to late winter. The quasi-biennial oscillation and Pacific decadal oscillation affect late winter clustering, while the Arctic oscillation dominates early winter. Climate modes also strongly influence AR orientation, with ENSO particularly affecting the orientation of temporally clustered ARs.
National ecosystem restoration pledges are mismatched with social-ecological enabling conditions
Authors: Benra Felipe , Brück Maria , Sigman Emily , Pacheco-Romero Manuel , Shumi Girma , Abson David J. , Frietsch Marina , Fischer Joern 
Published: November 2024

AbstractEcosystem restoration is widely recognized as a key strategy to address social-ecological challenges. National governments have pledged to restore millions of hectares of land. However, the ability to accomplish these pledges remains opaque, because restoration efforts are influenced by complex social-ecological factors. We provide a global analysis of national-level enabling and hindering conditions and their relation to restoration pledges undertaken by different nations. We developed an archetype characterization of within-country conditions using biophysical, socio-economic and governance indicators. Additionally, we investigated between-country conditions by examining flows of embodied land. Our analysis suggests that the countries with the most ambitious restoration pledges also tend to have the weakest enabling conditions (and vice versa). These results highlight the need to account for social, economic and governance factors alongside biophysical factors when considering where restoration ought to take place.
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Authors: Brauer Berit K , Chen Zilei , Beirow Felix , Li Jiaran , Meisinger Daniel , Capriotti Emanuela , Schweizer Michaela , Wagner Lea , Wienberg Jascha , Hobohm Laura , Blume Lukas , Qiao Wenjie , Narimatsu Yoshiki , Carette Jan E , Clausen Henrik , Winter Dominic , Braulke Thomas , Jabs Sabrina , Voss Matthias 
Published: November 2024

AbstractGlycosylation, which plays an important role in modifying lipids and sorting of proteins, is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi enzymes. We found that cells lacking LYSET/TMEM251, a retention factor for Golgi N-acetylglucosamine-1-phosphotransferase (GNPT), display SPPL3-dependent hypersecretion of the Golgi membrane protein B4GALT5. We demonstrate that in wild-type cells B4GALT5 is tagged with mannose 6-phosphate (M6P), a sorting tag typical of soluble lysosomal hydrolases. Hence, M6P-tagging of B4GALT5 may represent a novel degradative lysosomal pathway. We also observed B4GALT5 hypersecretion and prominent destabilization of LYSET–GNPT complexes, impaired M6P-tagging, and disturbed maturation and trafficking of lysosomal enzymes in multiple human cell lines lacking the COPI adaptors GOLPH3 and GOLPH3L. Mechanistically, we identified LYSET as a novel, atypical client of GOLPH3/GOLPH3L. Thus, by ensuring the cis-Golgi localization of the LYSET–GNPT complex and maintaining its Golgi polarity, GOLPH3/GOLPH3L is essential for the integrity of the M6P-tagging machinery and homeostasis of lysosomes.
BBSome-deficient cells activate intraciliary CDC42 to trigger actin-dependent ciliary ectocytosis
Authors: Prasai Avishek , Ivashchenko Olha , Maskova Kristyna , Bykova Sofiia , Schmidt Cernohorska Marketa , Stepanek Ondrej , Huranova Martina 
Published: November 2024

AbstractBardet-Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of the BBSome, a cargo adaptor essential for export of transmembrane receptors from cilia. Although actin-dependent ectocytosis has been proposed to compensate defective cargo retrieval, its molecular basis remains unclear, especially in relation to BBS pathology. In this study, we investigated how actin polymerization and ectocytosis are regulated within the cilium. Our findings reveal that ciliary CDC42, a RHO-family GTPase triggers in situ actin polymerization, ciliary ectocytosis, and cilia shortening in BBSome-deficient cells. Activation of the Sonic Hedgehog pathway further enhances CDC42 activity specifically in BBSome-deficient cilia. Inhibition of CDC42 in BBSome-deficient cells decreases the frequency and duration of ciliary actin polymerization events, causing buildup of G protein coupled receptor 161 (GPR161) in bulges along the axoneme during Sonic Hedgehog signaling. Overall, our study identifies CDC42 as a key trigger of ciliary ectocytosis. Hyperactive ciliary CDC42 and ectocytosis and the resulting loss of ciliary material might contribute to BBS disease severity.
Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response
Authors: Wang Wen-Han , Chen Hsuan-Yu , Chen Sheng-Yuan , Lan Chung-Yu 
Published: November 2024

Abstract
Candida albicans is a member of the human commensal microbiota but can also cause opportunistic infections, including life-threatening invasive candidiasis, particularly in immunocompromised patients. One of the important features of C. albicans commensalism and virulence is its ability to adapt to diverse environmental stress conditions within the host. Rap1 is a DNA-binding protein identified in yeasts, protozoa, and mammalian cells, and it plays multiple functions, including telomere regulation. Intriguingly, our previous study showed that Rap1 is also involved in cell wall integrity, biofilm formation, and virulence in C. albicans. In this work, using RNA-seq analysis and other approaches, the role of C. albicans Rap1 in oxidative stress response was further revealed. The RAP1-deletion mutant exhibited greater resistance to the superoxide generator menadione, a lower level of intracellular reactive oxygen species (ROS) upon menadione treatment, and higher expression levels of superoxide dismutase genes, all in response to oxidative stress. Moreover, the association between Rap1-mediated oxidative stress response and the mitogen-activated protein kinase (MAPK) Hog1, the transcription factor Cap1 and the TOR signalling was also determined. Together, these findings expand our understanding of the complex signalling and transcriptional mechanisms regulating stress responses in C. albicans.
The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension
Authors: Rathee Jitesh Singh , Iyer Dhanya R. , Kiranmayi Malapaka , Reddy Samarasimha , Sureshbabu V.V. , Mahapatra Nitish R. 
Published: November 2024

Abstract
Catestatin (CST), a 21-amino acids physiological peptide, has emerged as a key modulator of cardiovascular functions due to its anti-hypertensive and cardioprotective properties. However, the ramifications of the most common human variant of CST (viz., Gly364Ser) on cardiovascular pathophysiology remain partially understood. In this study, hypertension was induced in uninephrectomized rats by treatment with deoxycorticosterone-acetate and sodium chloride (DOCA-salt). The DOCA-salt-induced hypertensive (DSHR) animals were then intraperitoneally administered with either CST wild-type (CST-WT) or 364Ser variant (CST-Ser) peptide. CST-Ser was profoundly less effective than CST-WT in rescuing the elevated systolic blood pressure [from ∼211 mmHg to ∼176 mmHg, p &lt; 0.0001 (CST-Ser) versus ∼116 mmHg, p &lt; 0.0001 (CST-WT)] and heart rate [from ∼356 bpm to ∼314 bpm, p = 0.66 (CST-Ser) versus ∼276 bpm, p = 0.02 (CST-WT)]. CST-Ser also showed diminished effects in lowering diastolic blood pressure and mean arterial pressure in the DSHR animals. Furthermore, CST-Ser was inefficient/markedly less potent in rescuing the impaired contractile and diastolic function in DSHR animals [improvements in the contractility index by ∼22 s–1 (CST-Ser), p = 0.15 versus by ∼84 s–1 (CST-WT), p &lt; 0.0001 and decrease in end-diastolic pressure by ∼4 mmHg (CST-Ser), p = 0.015 versus by ∼14 mmHg (CST-WT), p &lt; 0.0001]. Moreover, CST-Ser exerted less potent anti-inflammatory effects on the DSHR hearts than CST-WT. These findings are in concordance with the elevated systolic/diastolic blood pressure observed in Ser variant carriers from various human populations. This study provides compelling evidence for the diminished anti-hypertensive and cardioprotective effects of the CST-Gly364Ser variant.
A Viewpoint on the Ethics of Pseudostuttering Assignments: Guidelines and Best Practices for Their Use
Authors: Gore Katie , Tichenor Seth E. 
Published: November 2024

Purpose:
Pseudostuttering, or the act of voluntarily stuttering or stuttering on purpose, has been both regularly used by clinicians alongside clients in stuttering therapy and taught to students in stuttering courses for decades. However, in recent years, teaching speech-language pathology students how to pseudostutter in stuttering courses has been increasingly questioned by students on grounds that pseudostuttering may be ableist, a disability simulation, and of questionable clinical value. The purpose of this article is to discuss the value and ethics of pseudostuttering assignments as part of graduate clinical education for speech-language pathologists (SLPs).

Method:
The history of pseudostuttering and the pseudostuttering assignment within speech-language pathology pedagogy, disability studies literature, and community perspectives are reviewed. In so doing, we incorporate views from the broader disability rights community, the stuttering community, and stuttering research and clinical literature.

Results:
Stuttering literature and community perspectives not only confirm the value of pseudostuttering assignments but also underscore the critical importance of assignment purpose, framing, structure, and scope.

Conclusions:
Pseudostuttering continues to be a critical clinical skill for SLPs who work with people who stutter, and pseudostuttering assignments are an invaluable learning experience for speech-language pathology graduate students. However, assignments must be designed and implemented according to a specific set of principles and best practices. Assignment design that does not follow these principles and best practices is likely to perpetuate ableist constructs and inadequately prepare students to work with individuals who stutter. Graduate course instructors should educate themselves on these principles and engage with students who express concerns with the assignment.
Microbiome and Communication Disorders: A Tutorial for Clinicians
Authors: Venkatraman Anumitha , Davis Ruth , Tseng Wen-Hsuan , Thibeault Susan L. 
Published: November 2024

Purpose:
Emerging research in the field of microbiology has indicated that host–microbiota interactions play a significant role in regulating health and disease. Whereas the gut microbiome has received the most attention, distinct microbiota in other organs (mouth, larynx, and trachea) may undergo microbial shifts that impact disease states. A comprehensive understanding of microbial mechanisms and their role in communication and swallowing deficits may have downstream diagnostic and therapeutic implications.

Method:
A literature review was completed to provide a broad overview of the microbiome, including differentiation of commensal versus pathogenic bacteria; cellular mechanisms by which bacteria interact with human cells; site-specific microbial compositional shifts in certain organs; and available reports of oral, laryngeal, and tracheal microbial dysbiosis in conditions that are associated with communication and swallowing deficits.

Results/Conclusions:
This review article is a valuable tutorial for clinicians, specifically introducing them to the concept of dysbiosis, with potential contributions to communication and swallowing deficits. Future research should delineate the role of specific pathogenic bacteria in disease pathogenesis to identify therapeutic targets.
A novel deep reinforcement learning‐based algorithm for multi‐objective energy‐efficient flow‐shop scheduling
Authors: Liang Peng , Xiao Pengfei , Li Zeya , Luo Min , Zhang Chaoyong 
Published: November 2024

AbstractA novel algorithm combining bidirectional recurrent neural networks (BiRNNs) with temporal difference is proposed for multi‐objective energy‐efficient non‐permutation flow‐shop scheduling problem (NFSP). The objectives of this problem involve minimising both the makespan and total energy consumption. To begin, a mathematical model is formulated to represent the energy‐efficient NFSP. Subsequently, the NFSP is transformed into a Markov decision process, where an action space comprising 28 scheduling rules is constructed. Considering the global and local features of NFSP, a set of 15 state features is extracted. Different reward functions are then defined to correspond to the specific objectives. Furthermore, the state features of NFSP are extracted using a multi‐layer perceptron model based on BiRNNs. By utilising the TD(λ) algorithm to calculate the state value function, various policies are generated. In order to evaluate the proposed algorithm, a new test set for the energy‐efficient NFSP is constructed, building upon classic benchmark problems. Finally, comparison experiments are conducted to demonstrate the effectiveness and efficiency of the proposed algorithm.
A related convolutional neural network for cancer diagnosis using microRNA data classification
Authors: Jaddi Najmeh Sadat , Abdullah Salwani , Goh Say Leng , Hasan Mohammad Kamrul 
Published: November 2024

AbstractThis paper develops a method for cancer classification from microRNA data using a convolutional neural network (CNN)‐based model optimized by genetic algorithm. The convolutional neural network has performed well in various recognition and perception tasks. This paper contributes to the cancer classification using a union of two CNNs. The method's performance is boosted by the relationship between CNNs and exchanging knowledge between them. Besides, communication between small sizes of CNNs reduces the need for large size CNNs and, consequently, the computational time and memory usage while preserving high accuracy. The method proposed is tested on microRNA dataset containing the genomic information of 8129 patients for 29 different types of cancer with 1046 gene expression. The classification accuracy of the selected genes obtained by the proposed approach is compared with the accuracy of 22 well‐known classifiers on a real‐world dataset. The classification accuracy of each cancer type is also ranked with the results of 77 classifiers reported in previous works. The proposed approach shows accuracy of 100% in 24 out of 29 classes and in seven cases out of 29, the method achieved 100% accuracy that no classifier in other studies has reached. Performance analysis is performed using performance metrics.
CASSC: Context‐aware method for depth guided semantic scene completion
Authors: Cao Jinghao , Li Ming , Liu Sheng , Li Yang , Du Sidan 
Published: November 2024

AbstractSemantic scene completion is a crucial end‐to‐end 3D perception task, and the 3D information perception subjects is vital for autonomous driving. This paper presents CASSC, a novel adaptive context‐aware method based on Transformer networks, aimed at realizing camera‐based semantic scene completion algorithms. The key idea is to leverage rich context information from images to obtain pixel‐level label proposals, followed by designing a multiscale fusion mechanism to merge this information and match it with voxel space. A weakly supervised training strategy is proposed to obtain semantic label distribution features from images and introduce an adaptive multiscale fusion module to fuse and adaptively match these features with voxel space. Here, CASSC achieves state‐of‐the‐art performance on the SemanticKITTI dataset and demonstrates excellent performance on the SSC‐Bench dataset. Ablation experiments validate the rationality and effectiveness of our design, and the model and code of CASSC will be open‐sourced on https://github.com/dogooooo/CASSC.
Risk‐based maximum speed advisory system for driving safety of connected and automated bus
Authors: Tak Sehyun , Kim Sari , Lee Donghoun 
Published: November 2024

AbstractBus rapid transit (BRT) system is a cost‐effective way to provide public transportation service. However, it faces some challenges such as reduced labour productivity and increasing fuel costs. One solution is introducing automated vehicles (AV) to reduce operational expenses. However, there are still limitations on completely replacing human drivers even in limited operational design domains (ODD). Furthermore, AVs often suffer from poor driving stability in some roadways, such as abrupt changes in road geometry. To enhance the driving safety of AV‐based BRT services, this study develops a new connected and automated bus (CAB) system using a cloud‐based traffic management centre with cooperative intelligent transportation systems. The proposed system introduces risk‐based maximum speed advisory system (RMSAS), which controls the maximum advisory speed of CAB to reduce its driving risk. This research evaluates the performance of RMSAS by comparing it to other driving modes, such as human‐driven vehicles and conventional AVs, based on real‐world field operational tests. The result shows that the proposed system outperforms other driving modes in terms of driving risks, particularly in some road geometry‐related ODDs. Hence, this research concludes that the proposed system can be applied to the AV‐based BRT service for uprating its safety performance.