bluuebunny/crossref_metadata_2025_split huggingface dataset:
SurfaceGenie: a web-based application for prioritizing cell-type specific marker candidates
Authors: Waas Matthew , Snarrenberg Shana T. , Littrell Jack , Jones Lipinski Rachel A. , Hansen Polly A. , Corbett John A. , Gundry Rebekah L. 
Published: March 2019

AbstractMotivationCell-type specific surface proteins can be exploited as valuable markers for a range of applications including immunophenotyping live cells, targeted drug delivery, and in vivo imaging. Despite their utility and relevance, the unique combination of molecules present at the cell surface are not yet described for most cell types. A significant challenge in analyzing ‘omic’ discovery datasets is the selection of candidate markers that are most applicable for downstream applications.ResultsHere, we developed GenieScore, a prioritization metric that integrates a consensus-based prediction of cell surface localization with user-input data to rank-order candidate cell-type specific surface markers. In this report, we demonstrate the utility of GenieScore for analyzing human and rodent data from proteomic and transcriptomic experiments in the areas of cancer, stem cell, and islet biology. We also demonstrate that permutations of GenieScore, termed IsoGenieScore and OmniGenieScore, can efficiently prioritize co-expressed and intracellular cell-type specific markers, respectively.Availability and ImplementationCalculation of GenieScores and lookup of SPC scores is made freely accessible via the SurfaceGenie web-application: www.cellsurfer.net/surfacegenie.
Population dynamics and age-dependent mortality processes in tropical reptiles
Authors: Cayuela Hugo , Akani Godfrey C. , Hema Emmanuel M. , Eniang Edem A. , Amadi Nioking , Ajong Stephanie N. , Dendi Daniele , Petrozzi Fabio , Luiselli Luca 
Published: March 2019

AbstractUnderstanding age-dependent mortality processes is a critical challenge for population biologists. Actuarial senescence appears to be a common process across the tree of life. Senescence patterns are highly variable in pluricellular organisms: senescence can be gradual or sharp and its onset may be early or delayed. By contrast, studies revealed that organisms may also not experience senescence at all while others display a “negative senescence”; i.e. a decrease of mortality rate with age. To date, studies on senescence have largely focused on human and other endotherm vertebrates, limiting our understanding of senescence in amniotes as a whole. By contrast, few have examined the diversity of senescence patterns in ectotherm vertebrates as reptiles. Here, we examined population dynamics and age-dependent mortality patterns in three tropical tortoises (Kinixys erosa, Kinixys homeana, Kinixys nogueyi) and snakes (Bitis gabonica, Bitis nasicornis, Causus maculatus). Our study revealed that tortoises ofKinixysgenus had a higher survival and a lower recruitment than snakes of the generaBitisandCausus, indicating that they have a slower life history. Furthermore, we showed that survival more slowly decreased with age in tortoises than in snakes. In addition, we highlighted contrasted patterns of age-dependent mortality in the three genera. InKinixys, the relationship between mortality rate and age was positive and linear, suggesting gradual senescence over tortoise lifetime. By contrast, the relationship between mortality rate and age was negative and sharp inBitisandCausus, possibly due to a “negative senescence” starting early in life. Our study highlighted various age-dependent mortality patterns in tropical reptiles. It also contributed to extend our knowledge of senescence in ectotherm vertebrates whose the demography is still poorly understood. In addition, while negative senescence has never been reported in endotherm vertebrates, our results showed that it can be common phenomenon in ectotherms.
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
Authors: Koga Tomoyuki , Chaim Isaac A. , Benitez Jorge A. , Markmiller Sebastian , Parisian Alison D. , Hevner Robert F. , Turner Kristen M. , Hessenauer Florian M. , D’Antonio Matteo , Nguyen Nam-phuong D. , Saberi Shahram , Ma Jianhui , Miki Shunichiro , Boyer Antonia D. , Ravits John , Frazer Kelly A. , Bafna Vineet , Chen Clark C. , Mischel Paul S. , Yeo Gene W. , Furnari Frank B. 
Published: March 2019

ABSTRACTMany current cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a new cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that capture authentic cancer pathobiology. Orthotopic engraftment of neural progenitor cells derived from hiPSCs that have been genome-edited to contain tumor-associated genetic driver mutations revealed by The Cancer Genome Atlas project for glioblastoma (GBM) result in formation of high-grade gliomas. As observed in GBM patient samples, these models harbor inter-tumor heterogeneity resembling different GBM molecular subtypes, and intra-tumor heterogeneity. Further, re-engraftment of primary tumor neurospheres generates secondary tumors with features characteristic of patient samples and present mutation-dependent patterns of tumor evolution. Thus, these cancer avatar models provide a platform for a comprehensive longitudinal assessment of human tumor development as governed by molecular subtype mutations and lineage-restricted differentiation.
Intrinsic Cell-type Selectivity and Inter-neuronal Connectivity Alteration by Transcranial Focused Ultrasound
Authors: Yu Kai , Niu Xiaodan , Krook-Magnuson Esther , He Bin 
Published: March 2019

ABSTRACTTranscranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We investigate the effect of tFUS stimulation on different neuron types and synaptic connectivity in in vivo anesthetized rodent brains. Single units were separated into regular-spiking and fast-spiking units based on their extracellular spike shapes, further validated in transgenic optogenetic mice models of light-excitable excitatory and inhibitory neurons. For the first time, we show that excitatory neurons are significantly less responsive to low ultrasound pulse repetition frequencies (UPRFs), whereas the spike rates of inhibitory neurons do not change significantly across all UPRF levels. Our results suggest that we can preferentially target specific neuron types noninvasively by altering the tFUS UPRF. We also report in vivo observation of long-term synaptic connectivity changes induced by noninvasive tFUS in rats. This finding suggests tFUS can be used to encode temporally dependent stimulation paradigms into neural circuits and non-invasively elicit long-term changes in synaptic connectivity.
Rapid recalibration of temporal order judgements: Response bias accounts for contradictory results
Authors: Keane Brendan , Bland Nicholas S. , Matthews Natasha , Carroll Timothy J , Wallis Guy 
Published: March 2019

AbstractRecent findings indicate that timing perception is systematically changed after only a single presentation of temporal asynchrony. This effect is known as rapid recalibration. In the synchrony judgement task, similar timing relationships in consecutive trials seem more synchronous (positive rapid recalibration; Van der Burg et al., 2013, 2015). Interestingly, the direction of this effect is reversed for temporal order judgements (negative rapid recalibration; Roseboom, 2019). We aimed to determine whether negative rapid recalibration of temporal order judgements (TOJs) reflects genuine rapid temporal recalibration, or a choice-repetition bias unrelated to timing perception. In our first experiment we found no evidence of rapid recalibration of TOJs, but positive rapid recalibration of associated confidence. This suggests that timing perception had rapidly recalibrated, but that this was undetectable in TOJs, plausibly because the positive recalibration effect was obfuscated by a large negative bias effect. In our second experiment, we dissociated participants’ previous TOJ from the most recently presented timing relationship, mitigating the choice-repetition bias effect, and found evidence of positive rapid recalibration of TOJs. We therefore conclude that timing perception is rapidly recalibrated positively for both synchrony and temporal order judgements. It remains unclear whether rapid recalibration occurs at the level of sensory processing, leading to similar effects in all subsequent judgements, or reflects a generalised decision-making strategy.
Effect of Interpopulation Spike-Timing-Dependent Plasticity on Synchronized Rhythms in Neuronal Networks with Inhibitory and Excitatory Populations
Authors: Kim Sang-Yoon , Lim Woochang 
Published: March 2019

We consider a two-population network consisting of both inhibitory (I) interneurons and excitatory (E) pyramidal cells. This I-E neuronal network has adaptive dynamic I to E and E to I interpopulation synaptic strengths, governed by interpopulation spike-timing-dependent plasticity (STDP). In previous works without STDPs, fast sparsely synchronized rhythms, related to diverse cognitive functions, were found to appear in a range of noise intensityDfor static synaptic strengths. Here, by varyingD, we investigate the effect of interpopulation STDPs on fast sparsely synchronized rhythms that emerge in both the I- and the E-populations. Depending on values ofD, long-term potentiation (LTP) and long-term depression (LTD) for population-averaged values of saturated interpopulation synaptic strengths are found to occur. Then, the degree of fast sparse synchronization varies due to effects of LTP and LTD. In a broad region of intermediateD, the degree of good synchronization (with higher synchronization degree) becomes decreased, while in a region of largeD, the degree of bad synchronization (with lower synchronization degree) gets increased. Consequently, in each I- or E-population, the synchronization degree becomes nearly the same in a wide range ofD(including both the intermediate and the largeDregions). This kind of “equalization effect” is found to occur via cooperative interplay between the average occupation and pacing degrees of spikes (i.e., the average fraction of firing neurons and the average degree of phase coherence between spikes in each synchronized stripe of spikes in the raster plot of spikes) in fast sparsely synchronized rhythms. Finally, emergences of LTP and LTD of interpopulation synaptic strengths (leading to occurrence of equalization effect) are intensively investigated via a microscopic method based on the distributions of time delays between the pre- and the post-synaptic spike times.PACS numbers87.19.lw, 87.19.lm, 87.19.lc
Towards a real-world brain-computer interface for image retrieval
Authors: McCartney Ben , Martinez-del-Rincon Jesus , Devereux Barry , Murphy Brian 
Published: March 2019

AbstractBrain decoding — the process of inferring a person’s momentary cognitive state from their brain activity — has enormous potential in the field of human-computer interaction. In this study we propose a zero-shot EEG-to-image brain decoding approach which makes use of state-of-the-art EEG preprocessing and feature selection methods, and which maps EEG activity to biologically inspired computer vision and linguistic models. We apply this approach to solve the problem of identifying viewed images from recorded brain activity in a reliable and scalable way. We demonstrate competitive decoding accuracies across two EEG datasets, using a zero-shot learning framework more applicable to real-world image retrieval than traditional classification techniques.
Consumer attitude towards sales promotion techniques: a multi-country study
Authors: Fam Kim-Shyan , Brito Pedro Q. , Gadekar Mahesh , Richard James E. , Jargal Ugtakh , Liu Wenchao 
Published: March 2019

PurposeThe purpose of this paper is to examine and compare the influence of age, education, income, product involvement and sales promotion (SP) characteristics on consumer attitudes towards SP across eight culturally dissimilar environments.Design/methodology/approachA multi-country mall intercept and mail survey was conducted in Brunei, China, Hong Kong, Indonesia, Malaysia, New Zealand, Singapore and Thailand (n=4,125 respondents).FindingsCountry, education level and income significantly influence consumer attitudes towards SP. Some countries show a significant monetary value interaction effect. Consumers using delayed-reward SPT reported a significantly more positive attitude towards SP. Discounts and coupons are the two most highly ranked SP across the sampled countries.Research limitations/implicationsLimitations include the use of intercept and mail sampling. Extending the study to include additional Asian countries and other regions would benefit the understanding of cultural influences on SP.Practical implicationsMultinational marketing managers should consider three aspects of SP implementation strategy: cultural and demographic factors, interaction between delayed-reward SP and socio-demographics variables; country specific SP preferences to promote both sales and brand equity.Originality/valueThis study investigates and extends research on SP across cultures. In particular the research helps better understand the impact of demographic factors and culture on attitudes towards SP, and implementation of global promotions.
A multiple-item scale for measuring “sustainable consumption behaviour” construct
Authors: Quoquab Farzana , Mohammad Jihad , Sukari Nurain Nisa 
Published: March 2019

PurposeThe purpose of this paper is to develop a reliable and valid scale with desirable psychometric properties and sufficient level of reliability and validity to measure sustainable consumption from consumer perspective.Design/methodology/approachIn achieving this objective: the domain of the construct is specified; items are generated through qualitative interviews; the initial scale is purified, and finally it is validated. A survey yielded 1,002 complete, usable questionnaires in order to run the analysis. Data were splitted in half. First half was utilised for exploratory factor analysis (EFA) and the second half of the data were utilised to run confirmatory factor analysis (CFA). The initial pool of item was tested using EFA via SPSS version 23. The CFA was conducted using SmartPLS-3.2.7 to confirm the dimensionality of sustainable consumption behaviour (SCB) scale.FindingsThe EFA result revealed that SCB is a three-dimensional construct which is consisted of 24 items. The scale includes: quality of life; care for environmental well-being; and care for the future generation. The CFA confirmed the dimensionality, reliability and validity of the SCB scale.Research limitations/implicationsThis sustainable consumption scale can be used to determine individual’s level of responsibility towards living a quality life, environment welfare, as well as responsibility towards sustainability of the future generation. It is expected that this initiative will stimulate further research on regional, cultural and demographic differences in understanding sustainable development.Practical implicationsMarketing practitioners may benefit from this scale by understanding the SCB of the socially and environmentally conscious consumers. It may eventually assist them to shape their strategies to meet the increasing demands of environmentalists.Originality/valueThe notion of sustainable consumption received significant research attention in present decade. It is regarded as one of the major catalysts of the sustainable development. However, in most cases sustainable consumption phenomenon is discussed from greater economic perspective and not much effort has been paid to consider it from consumer’s perspective. Furthermore, there is a lack of readily available scale to measure this construct in the existing literature.
Analysis of the moral mechanism to purchase counterfeit luxury goods: evidence from China
Authors: Jiang Yushi , Miao Miao , Jalees Tariq , Zaman Syed Imran 
Published: March 2019

PurposeThe purpose of this paper is to extend the theory of reasoned action and the theory of planned behaviour to measure the effects of ethical and moral antecedents (e.g. integrity, moral judgement, extrinsic religiosity and intrinsic religiosity, and ethical concern) on attitudes towards counterfeit luxury products. Additionally, it also measured the effects on attitudes towards purchase intention.Design/methodology/approachThe scope of the study is the Chinese market. The sample size for the study was 412 participants, and data were collected through established scales and measures. Structural equation modelling was used to test the developed model.FindingsAll the developed hypotheses were accepted. All the antecedents negatively affect attitudes towards counterfeit luxury products. At the same time, attitude has a positive effect on purchase intention. The results are consistent with those of earlier studies.Research limitations/implicationsSamples were gathered from just a single region in southwest China, which limits the generalisability of the discoveries. As past research in fake goods buying has done, future investigations relating to this situation in the domain of ethical reasoning should accumulate samples from other regions of China as well, as customer perception relating to profound morality and counterfeit Purchase Intention may change from region to region.Practical implicationsA few customers hold the opinion that luxury brands are lucrative because of the excessive costs of their products and therefore feel vindicated in buying counterfeits (Penz and Stottinger, 2005). Combatting this conviction requires luxury brand managers to endorse effective moral ideals and social commitment messages to prevail upon purchasers.Social implicationsA few customers trust that they are helping local people, such as the peddlers who offer the fakes or the producers who make these goods, suggesting in a way that a few individuals have positive attitudes towards these type of counterfeit goods sold locally. For such customers, there can be marketing messages that can show them the other side of the issue, such as the lost sales and loss caused to the organisations, which result in people becoming jobless because of their actions.Originality/valueThe primary goal of the study is to explore the relationship between the moral measurements of consumers and their attitudes and purchase intentions in the Chinese market.
Ethically minded consumer behaviour in Vietnam
Authors: Le Tri D. , Kieu Tai Anh 
Published: March 2019

Purpose
Consumer ethics in Asia has attracted attention from marketing scholars and practitioners. Ethical beliefs and judgements have been predominantly investigated within this area. Recent research argues for consumer ethics to be measured in terms of behaviours rather than attitudinal judgements, due to a potential pitfall of attitudinal scales, which researchers often refer to as an attitude–behaviour gap. Accordingly, the purpose of this paper is to examine the dimensions of ethically minded consumer behaviour (EMCB) in an Asian emerging market context.

Design/methodology/approach
A survey of 316 Vietnamese consumers was conducted to investigate their ethically minded behaviours.

Findings
The SEM analyses reveal a significant impact of long-term orientation on EMCB, whereas spirituality has no impact. Collectivism, attitude to ethically minded consumption and subjective norms are found to influence the dimensions of EMCB. Age, income and job levels have effects on EMCB dimensions, but gender, surprisingly, has no effect.

Practical implications
The study can be beneficial to businesses and policy makers in Vietnam or any similar Asian markets, especially in encouraging people to engage with ethical consumption. Furthermore, it provides practitioners in Vietnam with a measurement instrument that can be used to profile and segment consumers.

Originality/value
This is among the first studies utilising and examining EMCB, especially in Vietnam where research into consumer ethics is scant. It contributes to the body of knowledge by providing a greater understanding of the impact of personal characteristics and cultural environment on consumer ethics, being measured by the EMCB scale which has taken into account the consumption choices. Furthermore, this study adds further validation to the EMCB scale.
Knowledge management and open innovation in agri-food crowdfunding
Authors: Cillo Valentina , Rialti Riccardo , Bertoldi Bernardo , Ciampi Francesco 
Published: March 2019

Purpose
The purpose of this paper is to analyze the relationship between knowledge management capabilities and successful open innovation within agri-food businesses. This particular piece of research focuses on agri-food businesses which utilize crowdfunding platforms.

Design/methodology/approach
The research adopts a survey-based methodology, which is useful in enhancing the generalization of results. The final sample includes 80 cases for the analysis. The model and the hypotheses were tested through a hierarchical regression model.

Findings
This research assesses the importance of knowledge management capabilities for successful open innovation in crowdfunding for agri-food businesses. In particular, it emerged that IT-based knowledge exploitation capabilities are enablers of open innovation strategies. Additionally, it emerged that knowledge exploration capabilities can positively mediate the relationship between IT-based knowledge exploitation capabilities and open innovation in the context of agri-food businesses.

Originality/value
To the authors’ best knowledge, few researchers have explored this topic and, as such, there is a need to better conceptualize this intriguing phenomenon and to provide empirical evidence to support it.
Utilizing co-design approach to identify various stakeholders’ roles in the protection of intangible place-making heritage
Authors: Wu Haorui , Hou Chaoping 
Published: March 2019

PurposeThe protection of traditional grassroots place-making knowledge and skills that comprise valuable intangible heritage has not been attracting enough attention in the field of post-disaster reconstruction and recovery. Based on the Guchengping Village’s reconstruction that followed the Lushan earthquake (Sichuan, China), the purpose of this paper is to identify the benefits of a co-design approach for post-disaster reconstruction and recovery, in order to ascertain various stakeholders’ contributions toward the protection of community-based intangible place-making heritage.Design/methodology/approachA qualitative method was employed to assist the professional designers in facilitating the co-design approach by bridging governments closer together with local communities. At the governmental level, focus groups and personal interviews were conducted to discover the government’s role in preserving the communities’ intangible heritage. At the community level, community-based workshops and family-based design partnerships engaged various community stakeholders to decipher their roles and contributions toward advancing the heritage age.FindingsAs the advocates of intangible heritage, all levels of government guaranteed that intangible heritage would be safeguarded in the government strategic plans. At the community level, local residents played a fundamental role as the grassroots protectors. Professional designers utilized cutting edge technologies to improve weaknesses found in the traditional knowledge and skills, by performing the protection in practice. Community-based service agencies promoted the value of heritage to address societal issues.Originality/valueThe co-design approach offered a new method of intangible heritage protection in post-disaster reconstruction and recovery by engaging different stakeholders, in order to effectively transfer the governmental strategic plans into community-based action plans, and in turn, enabled the grassroots voice to inform the government policies.