bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults
Authors: Shanbhag Sujata M , Greve Anders M , Aspelund Thor , Schelbert Erik B , Cao J Jane , Danielsen Ragnar , þorgeirsson Guðmundur , Sigurðsson Sigurður , Eiríksdóttir Guðný , Harris Tamara B , Launer Lenore J , Guðnason Vilmundur , Arai Andrew E 
Published: October 2018

Abstract

Aims
Non-ischaemic cardiomyopathies (NICM) can cause heart failure and death. Cardiac magnetic resonance (CMR) detects myocardial scar/fibrosis associated with myocardial infarction (MI) and NICM with late gadolinium enhancement (LGE). The aim of this study was to determine the prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in a community-based sample of older adults.

Methods and results
The ICELAND-MI cohort, a substudy of the Age, Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) study, provided a well-characterized population of 900 subjects after excluding subjects with pre-existing heart failure. Late gadolinium enhancement CMR divided subjects into four groups: MI (n = 211), major (n = 54) non-ischaemic fibrosis (well-established, classic patterns, associated with myocarditis, infiltrative cardiomyopathies, or pathological hypertrophy), minor (n = 238) non-ischaemic fibrosis (remaining localized patterns not meeting major criteria), and a no LGE (n = 397) reference group. The primary outcome was time to death or first heart failure hospitalization. During a median follow-up of 5.8 years, 192 composite events occurred (115 deaths and 77 hospitalizations for incident heart failure). After inverse probability weighting, major non-ischaemic fibrosis [hazard ratio (HR) 3.2, P < 0.001] remained independently associated with the primary endpoint, while MI (HR 1.4, P = 0.10) and minor non-ischaemic LGE (HR 1.2, P = 0.39) did not. Major non-ischaemic fibrosis was associated with a poorer outcome than MI (HR = 2.3, P = 0.001) in the adjusted analysis.

Conclusion
Major non-ischaemic patterns of myocardial fibrosis portended worse prognosis than no fibrosis/scar in an older community-based cohort. Traditional risk factors largely accounted for the effect of MI and minor non-ischaemic LGE.
Evidence, Judgment, and Belief at Will
Authors: Roeber Blake 
Published: October 2018

Abstract
Doxastic involuntarists have paid insufficient attention to two debates in contemporary epistemology: the permissivism debate and the debate over norms of assertion and belief. In combination, these debates highlight a conception of belief on which, if you find yourself in what I will call an ‘equipollent case’ with respect to some proposition p, there will be no reason why you can’t believe p at will. While doxastic involuntarism is virtually epistemological orthodoxy, nothing in the entire stock of objections to belief at will blocks this route to doxastic voluntarism. Against the backdrop of the permissivism debate and the literature on norms of belief and assertion, doxastic involuntarism emerges as an article of faith, not the obvious truth it’s usually purported to be.
Powerful bursts of water masers towards G25.65+1.05
Authors: Volvach L N , Volvach A E , Larionov M G , MacLeod G C , van den Heever S P , Wolak P , Olech M 
Published: October 2018

ABSTRACT
The results of long-term monitoring of the Galactic 22.2 GHz water masers associated with G25.65+1.05 using several telescopes are presented. We report a powerful double flare with peak flux densities of ∼60 and 130 kJy in 2017 September and 2017 November, respectively. We propose a linear relationship between the inverse of the square of the line width and the natural logarithm of the flux density of the flaring water maser feature. We infer from this that the flaring feature is unsaturated.
Tobacco Advertisement Liking, Vulnerability Factors, and Tobacco Use Among Young Adults
Authors: Lienemann Brianna A , Rose Shyanika W , Unger Jennifer B , Meissner Helen I , Byron M Justin , Baezconde-Garbanati Lourdes , Huang Li-Ling , Cruz Tess Boley 
Published: October 2018

AbstractIntroductionYoung adulthood (aged 18–24) is a crucial period in the development of long-term tobacco use patterns. Tobacco advertising and promotion lead to the initiation and continuation of smoking among young adults. We examined whether vulnerability factors moderated the association between tobacco advertisement liking and tobacco use in the United States.MethodsAnalyses were conducted among 9109 US young adults in the nationally representative Population Assessment of Tobacco and Health (PATH) Study wave 1 (2013–14). Participants viewed 20 randomly selected sets of tobacco advertisements (five each for cigarettes, e-cigarettes, cigars, and smokeless tobacco) and indicated whether they liked each ad. The outcome variables were past 30-day cigarette, e-cigarette, cigar, and smokeless tobacco use. Covariates included tobacco advertisement liking, age, sex, race or ethnicity, sexual orientation, education, poverty level, military service, and internalizing and externalizing mental health symptoms.ResultsLiking tobacco advertisements was associated with tobacco use, and this association was particularly strong among those with lower educational attainment (cigarettes, cigars) and living below the poverty level (e-cigarettes, smokeless tobacco).ConclusionsThe association between tobacco advertisement liking and tobacco use was stronger among young adults with lower educational attainment and those living below the poverty level. Policies that restrict advertising exposure and promote counter-marketing messages in this population could reduce their risk.ImplicationsThis study shows that liking tobacco advertisements is associated with current tobacco use among young adults, with stronger associations for vulnerable young adults (ie, lower education levels and living below the poverty level). Findings suggest a need for counter-marketing messages, policies that restrict advertising exposure, and educational interventions such as health and media literacy interventions to address the negative influences of tobacco advertisements, especially among young adults with a high school education or less and those living below the poverty level.
Effects of concentrate input on nutrient utilization and methane emissions of two breeds of ewe lambs fed fresh ryegrass
Authors: Wang Chunmei , Zhao Yiguang , Aubry Aurélie , Arnott Gareth , Hou Fujiang , Yan Tianhai 
Published: October 2018

Abstract
The objective of this study was to evaluate if high-quality grass could sustain a similar feeding efficiency to concentrate meals for two breeds of lowland ewe lambs. Sixteen lowland ewe lambs of approximately 13 mo age and 61.5 ± 5.28 kg live weight were used in a 2 × 2 factorial study, with 2 diets (fresh perennial ryegrass [Lolium perenne] vs. fresh perennial ryegrass plus 0.5 kg/d fresh concentrate) × 2 breeds (Highlander vs. Texel). Grass was cut daily in the morning from a single zero-grazing sward and offered ad libitum. The animals were individually housed in pens and fed experimental diets for an adaptation phase of 19 d, and then transferred to respiration calorimeter chambers, remaining there for 5 d, with feed intake, feces and urine outputs, and methane (CH4) emissions measured during the final 4 d. There were no significant interaction effects between diets and breeds on any variables. Ewe lambs offered 0.5 kg/d concentrate supplementation had slightly greater DM intake and energy (GE, DE, and ME) intake, but had significantly higher N intake and N excretion in feces and urine than those fed the grass-only diet. However, diets had no significant effects on nutrient digestibility, energy or N utilization, or CH4 emission. Texel breed had a significantly lower DM intake and CH4 emissions per kg live weight, whereas the breed had no significant effect on nutrient digestibility or energy or N utilization. These results implicate that good quality grass could sustain high nutrient utilization efficiency as effectively as diets supplemented with concentrates for ewe lamb production. The two breeds of lowland ewe lambs can utilize good quality grass at a similar level of efficiency.
Determinants of Corneal Endothelial Cell Loss After Trabeculectomy With Mitomycin C
Authors: Higashide Tomomi , Nishino Tsubasa , Sakaguchi Kimikazu , Yamada Yutaro , Sugiyama Kazuhisa 
Published: October 2018

Purpose:
To investigate factors associated with decreased corneal endothelial cell density (ECD) after trabeculectomy with mitomycin C (MMC).

Methods:
Retrospective review of consecutive glaucoma cases who underwent trabeculectomy with MMC. The types of glaucoma included were primary open-angle glaucoma, exfoliation glaucoma (XFG), neovascular glaucoma, and uveitic glaucoma (UG). The postoperative ECD changes compared with the preoperative ECD and risk factors for ECD decrease were analyzed using mixed-effects models.

Results:
In total, 162 eyes of 136 patients were included in this study. Postoperative ECD measurements were performed 3.7±1.8 times (mean±SD) during a median follow-up period of 34 months. The mean intraocular pressure decreased from 25.3±9.6 to 9.2±2.3 mm Hg postoperatively. The marginal mean (SE) ECD decrease at 24 months was 9.3% (1.3%) in all cases. The marginal mean ECD decrease at 24 months was 18.2% (3.1%) and 20.6% (4.7%) in eyes with XFG and UG, respectively, which was significantly greater than 4.8% (1.8%) in eyes with primary open-angle glaucoma (P<0.001, each), after accounting for the variability in the number and timepoint of ECD measurements. Multivariate mixed-effects model analyses showed that type of glaucoma (XFG and UG) and older age were significantly associated with larger ECD decrease, and preoperative factors (oral carbonic anhydrase inhibitor and vitrectomy) and postoperative choroidal detachment were significantly associated with a declining trend of ECD over time.

Conclusions:
The type of glaucoma (XFG, UG) and older age were risk factors for larger ECD decrease after trabeculectomy with MMC.
New Medicare Diabetes Prevention Coverage May Limit Beneficiary Access and Widen Health Disparities
Authors: Ritchie Natalie D. , Gritz Robert M. 
Published: October 2018

Background:
The Centers for Medicare and Medicaid Services recently issued final rules for the Medicare Diabetes Prevention Program (MDPP), offering an unprecedented opportunity to provide lifestyle intervention to Medicare beneficiaries with prediabetes via a pay-for-performance model. The MDPP is based on the widely disseminated, yearlong National Diabetes Prevention Program (NDPP), which has lesser but still beneficial risk-reduction outcomes among minority and low-income participants.

Objectives:
We compare projected payments based on outcomes of a diverse sample of Medicare beneficiaries to service delivery costs, and explore resulting implications for MDPP access and sustainability.

Methods:
We delivered NDPP in a safety-net health care system from 2013 to 2017 and conducted an analysis of service cost, beneficiary performance, and projected MDPP reimbursement.

Results:
Among 1165 total participants, 213 (18.3%) were Medicare beneficiaries. Participating beneficiaries were 40.6% Hispanic, 31.6% non-Hispanic black, and 26.9% non-Hispanic white and 69.5% low-income. Overall beneficiary performance would result in an average reimbursement of $138.52 (interquartile range=162.50). Program delivery costs were $800 per participant, leaving an average gap of $661 per beneficiary.

Conclusions:
Findings from delivering the NDPP to diverse and undeserved patients show a large gap between service costs and projected reimbursement. Although many MDPP suppliers are needed to reach all Medicare beneficiaries with prediabetes, insufficient reimbursement may be a deterrent. Health disparities may also widen as suppliers serving diverse and low-income populations will likely receive especially low payments, threatening access. Higher payments are supported by strong return-on-investment findings and seem needed to reduce diabetes prevalence and related disparities.
Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for the Occurrence of New Cancer in the Remnant Pancreas
Authors: Matsuda Ryota , Miyasaka Yoshihiro , Ohishi Yoshihiro , Yamamoto Takeo , Saeki Kiyoshi , Mochidome Naoki , Abe Atsushi , Ozono Keigo , Shindo Koji , Ohtsuka Takao , Kikutake Chie , Nakamura Masafumi , Oda Yoshinao 
Published: October 2018

Objective:
To determine the factors predicting the subsequent development of pancreatic ductal adenocarcinoma in remnant pancreas (PDAC-RP) after partial pancreatectomy for PDAC.

Summary Background Data:
PDAC-RP after partial pancreatectomy for PDAC is currently not so rare because of improved prognosis of PDAC patients due to recent advances in surgical techniques and adjuvant therapy. However, the predictive factors related to PDAC-RP remain unknown.

Methods:
We retrospectively reviewed the clinicopathological data of a consecutive series of 379 patients with PDAC treated by partial pancreatectomy between 1992 and 2015; 14 patients (3.69%) had PDAC-RP. Clinicopathological variables were compared between PDAC-RP and non-PDAC-RP.

Results:
In univariate analysis, concomitant intraductal papillary mucinous neoplasm (IPMN) (P = 0.0005), cancer location (body/tail) (P = 0.0060), and lower T factor in UICC (P = 0.0039) were correlated with PDAC-RP development. Multivariate analysis revealed concomitant IPMN (P = 0.0135) to be an independent predictive factor for PDAC-RP. PDAC concomitant with IPMN had higher cumulative incidence of PDAC-RP (47.5%/10 yrs) than PDAC without IPMN (9.96%/10 yrs) (P = 0.0071). Moreover, the density of pancreatic intraepithelial neoplasia lesions in the background pancreas of cases of PDAC concomitant with IPMN (1.86/cm2) was higher than that of cases of PDAC without IPMN (0.91/cm2) (P = 0.0007).

Conclusions:
Concomitant IPMN in PDAC is an independent predictive factor for the development of new PDAC in remnant pancreas. Cancer susceptibility of remnant pancreas after resection for PDAC concomitant with IPMN is probably due to an increased density of pancreatic intraepithelial neoplasia lesions.
Perforated Peptic Ulcer Surgery: Decreased Length of Stay but No Difference in Mortality with Laparoscopic Repair
Authors: Gabriel Viktor , Grigorian Areg , Schubl Sebastian D. , Pejcinovska Marija , Won Eugene , Lekawa Michael , Bernal Nicole , Nahmias Jeffry 
Published: October 2018

Background:
Perforated peptic ulcer (PPU) surgery mortality ranges 1% to 24%. We hypothesized a decrease in length of stay (LOS) with laparoscopic surgical repair (LSR) compared with open surgical repair (OSR).

Methods:
Patients undergoing PPU surgery 2005 to 2015 were identified in NSQIP. LSR was compared with OSR 2005 to 2015. LSR 2005 to 2010 was compared with 2011 to 2015. OSR 2005 to 2010 was compared with 2011 to 2015. The primary outcome was LOS. Secondary outcomes were mortality and morbidity.

Results:
Between 2005 and 2015, LSR had a decreased LOS, was more likely to wean from the ventilator, but had no significant difference in mortality compared with OSR. There was no significant difference in mortality for LSR or OSR over time.

Conclusions:
When patients are appropriately selected, LSR for PPU is a viable alternative to OSR, decreasing LOS and pulmonary complications. This demonstrates significant benefit to patients and hospital throughput.
Twenty-four hour versus extended antibiotic administration after surgery in complicated appendicitis: A randomized controlled trial
Authors: Saar Sten , Mihnovitš Vladislav , Lustenberger Thomas , Rauk Mariliis , Noor Erast-Henri , Lipping Edgar , Isand Karl-Gunnar , Lepp Jaak , Lomp Andrus , Lepner Urmas , Talving Peep 
Published: October 2018

BACKGROUND
Recent investigations noted noninferiority in short-course antimicrobial treatments following source control in abdominal infections. We set out to investigate noninferiority of a short and fixed (24 hours) antibiotic administration compared to extended treatment after source control in complicated appendicitis in a prospective single-center open-label randomized controlled trial.

METHODS
After Institutional Review Board (IRB) approval, all consecutive adult patients (age, ≥ 18 years) with complicated appendicitis including gangrenous appendicitis, perforated appendicitis, and appendicitis with periappendicular abscess between May 2016 and February 2018 were randomly allocated to antibacterial therapy limited to 24 hours (short) vs. >24 hours (extended) administration after appendectomy. Primary outcomes included composite postoperative complications and Comprehensive Complication Index (CCI). Secondary outcome was hospital length of stay (HLOS). Follow-up analysis at 1 month was conducted per intention and per protocol.

RESULTS
A total of 80 patients were enrolled with 39 and 41 cases allocated to the short and the extended therapy group, respectively. Demographic profile and disease severity was similar between the study groups. Overall rate of complications was 17.9% and 29.3% in the short and extended group, respectively (p = 0.23). Mean CCI did not differ between the study groups (p = 0.29). Hospital length of stay was significantly reduced in the short therapy group (61 ± 34 hours vs. 81 ± 40 hours, p = 0.005).

CONCLUSION
In the current prospective randomized investigation, the short (24 hours) antibiotic administration following appendectomy did not result in a worse primary outcome in complicated appendicitis. The short interval administration resulted in a significant reduction in HLOS with a major cost-saving and antibacterial stewardship perspective.

LEVEL OF EVIDENCE
Therapeutic Level IV.
Donor-specific Cell-free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review
Authors: Knight Simon Robert , Thorne Adam , Lo Faro Maria Letizia 
Published: October 2018

Background
There is increasing interest in the use of noninvasive biomarkers to reduce the risks posed by invasive biopsy for monitoring of solid organ transplants (SOTs). One such promising marker is the presence of donor-derived cell-free DNA (dd-cfDNA) in the urine or blood of transplant recipients.

Methods
We systematically reviewed the published literature investigating the use of cfDNA in monitoring of graft health after SOT. Electronic databases were searched for studies relating cfDNA fraction or levels to clinical outcomes, and data including measures of diagnostic test accuracy were extracted. Narrative analysis was performed.

Results
Ninety-five articles from 47 studies met the inclusion criteria (18 kidneys, 7 livers, 11 hearts, 1 kidney-pancreas, 5 lungs, and 5 multiorgans). The majority were retrospective and prospective cohort studies, with 19 reporting diagnostic test accuracy data. Multiple techniques for measuring dd-cfDNA were reported, including many not requiring a donor sample. dd-cfDNA falls rapidly within 2 weeks, with baseline levels varying by organ type. Levels are elevated in the presence of allograft injury, including acute rejection and infection, and return to baseline after successful treatment. Elevation of cfDNA levels is seen in advance of clinically apparent organ injury. Discriminatory power was greatest for higher grades of T cell–mediated and antibody-mediated acute rejection, with high negative predictive values.

Conclusions
Cell-free DNA is a promising biomarker for monitoring the health of SOTs. Future studies will need to define how it can be used in routine clinical practice and determine clinical benefit with routine prospective monitoring.
Factors Influencing Staff’s Attitude Toward Electroconvulsive Therapy
Authors: Scholz-Hehn Anne Deborah , Müller Jana Christina , Deml Ruben , Methfessel Isabel , Zilles David , Hädrich Florian , Hecht Gregory , Luedecke Daniel , Gornisch Janina , Albrecht Heiko , Stumm Laura , Freundlieb Nils 
Published: October 2018

Objectives
Despite being a highly effective treatment, electroconvulsive therapy (ECT) is still stigmatized even among professionals. The aim of this study was to identify factors associated with a positive attitude toward ECT among health care workers.

Methods
We investigated staff's attitude and their self-assessment of knowledge while introducing ECT in 3 German psychiatric clinics. Furthermore, we compared this data to that of a clinic where ECT has been applied with a long tradition. An anonymous questionnaire was answered by n = 182 employees in the ECT-introducing clinics (novices) and n = 68 employees in the clinic with a long history of ECT (experts).

Results
Irrespective of the clinical history, the majority of participants approved the application of ECT in their clinic. Factors associated with a positive attitude were (a) profession (physicians presented a more positive mindset about ECT than nursing staff), (b) subjective feeling of being adequately informed, and (c) having had contact to patients undergoing ECT. Interestingly, the general attitude toward ECT did not differ between subjects who reported to have seen an ECT and those who had not.

Conclusions
When introducing ECT as a new treatment into a clinic, formal information should be adapted to the needs of each profession with a special emphasis on nurses. To further increase acceptance, contact to ECT-experienced patients (professionals taught by patients) might result in a more positive attitude toward ECT than participation in an ECT treatment itself.