bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Pedukung Keputusan Seleksi Proposal Program Penerapan Iptek Bagi Masyarakat
Authors: Yanto Robi , Guntur Mohammad 
Published: May 2019

Pengabdian masyarakat merupakan salah satu bagian terpenting bagi perguruan tinggi untuk mewujudkan peran serta pembangunan bangsa dan negara. Banyaknya kriteria penilaian yang digunakan dalam proses seleksi proposal pengabdian masyarakat menuntut unit kegiatan pengabdian masyarakat untuk lebih teliti dalam melakukan proses seleksi sesuai dengan hasil penilaian reviewer. Untuk dapat membantu proses seleksi proposal pengabdian masyarakat dibutuhkan sistem pendukung keputusan yang dapat membantu proses penilaian yang lebih tepat dan objektif. Adapun tujuan penelitian ini adalah membangun Sistem pendukung keputusan menggunakan metode Simple Multi Attribute Rating Technique, dimana metode ini digunakan sebagai media bantu penentuan kriteria pemilihan berdasarkan bobot dari kriteria dan subkriteria untuk proses perangkingan terhadap alternatif. Dari analisa metode dan sistem dihasilkan penilaian terhadap proposal pengabdian masyarakat Tahun 2017 dengan rekomendasi sangat layak yaitu A1 dengan hasil perangkingan 83,75, A4=88, rekomendasi Layak yaitu A2 dengan hasil perangkingan 60,75 dan A5=63,25 dan rekomendasi tidak layak adalah A3 dengan hasil perangkingan 33.

Kata kunci: Pengabdian Masyarakat, PPIM, Sistem Pendukung Keputusan, Smart

Abstract
Community service is one of the most important parts for universities to realize the role of the nation and state development. A large number of assessment criteria used in the community service proposal selection process requires the community service unit to be more thorough in carrying out the selection process in accordance with the results of the reviewer assessment. To be able to help the community service proposal selection process, a decision support system is needed that can help a more precise and objective assessment process. The purpose of this study is to build a decision support system using the Simple Multi-Attribute Rating Technique method, where this method is used as an auxiliary media to determine selection criteria based on the weight of the criteria and sub-criteria for the ranking process against alternatives. From the analysis of methods and systems results in an assessment of 2017 community service proposals with recommendations that are very feasible namely A1 with a ranking of 83.75, A4 = 88, Worthy recommendation is A2 with ranking results of 60.75 and A5 = 63.25 and recommendations are not feasible is A3 with a ranking of 33.
Keywords: Community Service, PPIM, Decision Support System, Smart.
MASYARAKAT HUKUM ADAT DATUK SINARO PUTIH PASANG SURUT KEKUASAAN ADAT DI TENGAH HEGEMONI NEGARA
Authors: Ridwan  , Isman  
Published: May 2019

The Bungo District Government issued Bungo District Regulation No. 9 of 2007 concerning the mention of the Village Chief to Rio, the Village Becomes Dusun and Dusun Being the Kampung has raised several fundamental problems faced by the Indigenous Government of Datuk Sinaro Putih. The problem is the existence of dualism at the level of village institutions, which is caused by the Role of Rio (Village Chief) who is so free to regulate all adat issues in the indigenous law community Datuk Sinaro Putih which has been regulated by Customary Institutions led by Customary Leader. The method used is descriptive qualitative method. Existence of Customary Law Society Datuk Sinaro Putih still exists. Because they were officially recognized by the Bungo District Regulation No. 6 of 2006 concerning Customary Law Society Datuk Sinaro Putih. They still have customary forests as the ancestral heritage of Datuk Sinar Putih. The Hamlet Government has replaced the power of Datuk Sinaro Putih in the field of general government. However, customary power is still held by Datuk Sinaro Putih, including control of customary forest areas. The descendants of Datuk Sinaro Putih make an effort to maintain their existence, including designing Village Regulations on the Customary Law Community Datuk Sinaro Putih and holding annual and five-year events in the form of traditional vows and traditional art performances in the traditional unit of Datuk Sinaro Putih.
Keywords: customary law community, Datuk Sinaro Putih, customary power, state hegemony
Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study
Authors: Golchert Johannes , Roehr Susanne , Luck Tobias , Wagner Michael , Fuchs Angela , Wiese Birgitt , van den Bussche Hendrik , Brettschneider Christian , Werle Jochen , Bickel Horst , Pentzek Michael , Oey Anke , Eisele Marion , König Hans-Helmut , Weyerer Siegfried , Mösch Edelgard , Maier Wolfgang , Scherer Martin , Heser Kathrin , Riedel-Heller Steffi G. 
Published: May 2019

Background: Sex differences in verbal episodic memory function have been widely reported. However, sex-specific effects on rates of episodic memory decline remain controversial, and evidence is particularly scarce in the oldest-old population. Objective: We aimed to investigate sex differences in trajectories of episodic memory performance in oldest-old individuals. Methods: Based on 13-year longitudinal data with 9 follow-up assessments of a large sample of cognitively unimpaired old (75+) primary care patients ( n = 3,254) participating in the German AgeCoDe/AgeQualiDe study, we used linear mixed effects analyses to model sex-specific trajectories of change in verbal episodic memory while accounting for covarying factors. Results: We found that even in the highest age group women outperformed men in immediate ( b = –1.71, p < 0.001) and delayed ( b = –0.85, p < 0.001) free recall conditions. Associated late-life trajectories, however, did not differ significantly between the sexes. We further demonstrated that younger age, higher education, and an absence of depressive symptoms predicted better performance in both sexes. In contrast, past occurrences of stroke and APOE ɛ4 carrier status showed a negative relation to test scores. Conclusion: Our findings confirm previous research suggesting that women perform better in verbal episodic memory tests. We add that this advantage is still present in the oldest-old age groups. Our results indicate that sociodemographic and health related factors are as important as genetically based APOE ɛ4 carrier status in the prediction of normal cognitive development in advanced old age.
Moral Emotions in Frontotemporal Dementia
Authors: Teichmann Marc , Daigmorte Chloé , Funkiewiez Aurélie , Sanches Clara , Camus Maeva , Mauras Thomas , Le Ber Isabelle , Dubois Bruno , Levy Richard , Azuar Carole 
Published: May 2019

Background: Emotions, with or without moral valence, appear to be altered in the behavioral variant of frontotemporal dementia (bvFTD) but the relative degree of moral emotion breakdown, which could be a marker of bvFTD diagnosis, remains unexplored. Objective: To assess moral emotions in bvFTD, to differentiate bvFTD from typical Alzheimer’s disease (AD) based on moral emotion processing, and to provide a sensitive and specific assessment tool contributing to bvFTD diagnosis. Methods: We investigated moral emotions in 22 bvFTD patients, 15 patients with typical AD having positive CSF AD biomarkers, and 45 healthy controls. The ‘Moral Emotions Assessment’ task consisted in 42 scenarios exploring positive and negative moral emotions. To control for moral-specificity, we contrasted the 42 moral scenarios with 18 extra-moral scenarios eliciting the emotions without involving any inter-human moral context. Results: bvFTD patients were more impaired in emotion processing than AD patients and healthy controls and had significantly poorer performance in the processing of moral emotions than of emotions without moral valence. ROC analyses of data on moral scenarios showed a high area under the curve (83%), and indicated a cut-off score (< 37/42) for differentiating bvFTD from AD with a sensitivity of 82% and specificity of 73%. Conclusion: Our findings demonstrate that bvFTD patients have disorders in emotion processing which is mainly related to failure regarding moral emotions. They also show that this deficit is reliably detected by the ‘Moral Emotions Assessment’ which represents a sensitive and specific diagnostic tool detecting bvFTD and differentiating it from AD.
Detecting Apathy in Older Adults with Cognitive Disorders Using Automatic Speech Analysis
Authors: König Alexandra , Linz Nicklas , Zeghari Radia , Klinge Xenia , Tröger Johannes , Alexandersson Jan , Robert Philippe 
Published: May 2019

Background: Apathy is present in several psychiatric and neurological conditions and has been found to have a severe negative effect on disease progression. In older people, it can be a predictor of increased dementia risk. Current assessment methods lack objectivity and sensitivity, thus new diagnostic tools and broad-scale screening technologies are needed. Objective: This study is the first of its kind aiming to investigate whether automatic speech analysis could be used for characterization and detection of apathy. Methods: A group of apathetic and non-apathetic patients ( n = 60) with mild to moderate neurocognitive disorder were recorded while performing two short narrative speech tasks. Paralinguistic markers relating to prosodic, formant, source, and temporal qualities of speech were automatically extracted, examined between the groups and compared to baseline assessments. Machine learning experiments were carried out to validate the diagnostic power of extracted markers. Results: Correlations between apathy sub-scales and features revealed a relation between temporal aspects of speech and the subdomains of reduction in interest and initiative, as well as between prosody features and the affective domain. Group differences were found to vary for males and females, depending on the task. Differences in temporal aspects of speech were found to be the most consistent difference between apathetic and non-apathetic patients. Machine learning models trained on speech features achieved top performances of AUC = 0.88 for males and AUC = 0.77 for females. Conclusions: These findings reinforce the usability of speech as a reliable biomarker in the detection and assessment of apathy.
Rate of Cognitive Decline in Alzheimer’s Disease Stratified by Age
Authors: Stanley Karen , Whitfield Tim , Kuchenbaecker Karoline , Sanders Oliver , Stevens Tim , Walker Zuzana 
Published: May 2019

Background: There is only limited information available about the effect of age on course of cognitive decline in patients with onset of Alzheimer’s disease (AD) over the age of 64 years. Objective: We compared the rate of, and factors affecting, cognitive decline in patients with AD aged < 65 years (young-onset AD), 65–74 years (middle-onset AD), and ≥75 years (late-onset AD). Method: The study used longitudinal data from the Essex Memory Clinic which included a total of 305 participants; 56 had YOAD, 73 had MOAD, and 176 had LOAD. The rate of cognitive decline was measured using scores from the Mini-Mental State Examination (MMSE), and the data were examined using multilevel models analysis. Results: There was evidence of a difference in cognitive decline across the age groups with the YOAD group declining 2.8 MMSE points per year, those with MOAD declined 2.0 MMSE points per year, and the LOAD group declined 1.4 MMSE points per year. Conclusions: Patients with LOAD have a better prognosis than YOAD and MOAD. However, even between the MOAD and LOAD groups, age is a significant predictor of cognitive decline, with older patients having a more benign course.
Willingness to Adhere to Current UK Low-Risk Alcohol Guidelines to Potentially Reduce Dementia Risk: A National Survey of People Aged 50 and Over
Authors: Oliveira Deborah , Jones Katy A. , Ogollah Reuben , Ozupek Semanur , Hogervorst Eef , Orrell Martin 
Published: May 2019

Background: People over 50 are increasing their alcohol intake, potentially increasing their risk of dementia. Objective: This study investigates whether people would be willing to adhere to current United Kingdom (UK, “low-risk”) alcohol guidelines to reduce dementia risk. Methods: A national cross-sectional online survey recruited a non-probabilistic sample of 3,948 individuals aged 50 and over without dementia in the UK. Self-reported willingness to comply with low-risk guidelines was predicted using logistic regression. Other relevant self-reported variables included physical health, lifestyle, and current alcohol intake. Results: Majority of the sample (90%, n = 3,527) reported drinking alcohol at least once a month with 23% ( n = 795) exceeding the low-risk guidelines (> 14 units per week). A larger proportion of men, those who were overweight, and people without a partner reported drinking above the recommended level. Most people who consumed alcohol ( n = 2,934; 74.3%) appeared willing to adhere to low-risk guidelines if they were told that their risk of having dementia could be reduced. Increased willingness was found in women (OR 1.81; CI 1.47–2.23), in people who had at least one child (OR 1.36; CI 1.09–1.70), and those who slept well (OR 1.45; CI 1.06–2.00). People who were obese (OR 0.72; CI 0.54–0.95), those who drank alcohol above limits (OR 0.13; CI 0.11–0.16), and those who were smokers (OR 0.56; CI 0.36–0.88) were less willing to adhere to current guidelines. Conclusion: Men and people with more lifestyle risk factors for common chronic diseases (e.g., smoking, obesity, and excess alcohol consumption) are less willing to adhere to current alcohol low-risk guidelines to reduce dementia risk.
Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease
Authors: Haddad Mohamed , Perrotte Morgane , Landri Sarra , Lepage Aurelie , Fülöp Tamàs , Ramassamy Charles 
Published: May 2019

Background: Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine (CML) and pentosidine were found in the brain from Alzheimer’s disease (AD) patients and were associated with the neuropathological hallmarks of AD. In AD patients, the circulating level of both AGEs remains unknown. Moreover, their levels in peripheral extracellular vesicles (EVs) and their association with AD remain to be determined. Finally, it is not known if neuronal cells can release AGEs via EVs and propagate AGEs. Objective: To determine the levels of circulating CML and pentosidine during the progression of AD. Moreover, their levels in circulating EVs were determined and their association with the clinical cognitive scores were analyzed. Finally, we have studied the possibility that neuronal cells eliminate and transfer these AGEs through EVs. Methods: CML and pentosidine levels were measured in serum and in circulating EVs. Released-EVs from SK-N-SH neuronal cells were isolated and CML levels were also determined. Results: The levels of CML in albumin-free serum proteins were higher in the early stage of AD while the levels of pentosidine remained unchanged. In contrast, the levels of CML in the EVs were lower in the moderate stage of AD. Interestingly, the levels of CML in serum were negatively correlated with the clinical cognitive scores MMSE and MoCA. For the first time, we were able to demonstrate that CML was present in EVs released from neuronal cells in culture. Conclusion: Peripheral and circulating EVs levels of CML can differentiate early to moderate AD. In the brain, neuronal CML can propagate from cells-to-cells via EVs.
Hospital-Treated Pneumonia Associated with Opioid Use Among Community Dwellers with Alzheimer’s Disease
Authors: Hamina Aleksi , Taipale Heidi , Karttunen Niina , Tanskanen Antti , Tiihonen Jari , Tolppanen Anna-Maija , Hartikainen Sirpa 
Published: May 2019

Background: Pneumonia is a common cause for hospitalization and excess mortality among persons with Alzheimer’s disease (AD), but little research exists evaluating drug use as its risk factor. Objective: We investigated the association between opioid use and hospital-treated pneumonia among community dwellers with AD. Methods: This study was part of the Medication use and Alzheimer’s Disease (MEDALZ) cohort. We included all community dwellers newly diagnosed with AD during 2010–2011 in Finland with incident prescription opioid use ( n = 5,623) and age-, sex-, and time since AD diagnosis-matched nonusers ( n = 5,623). Opioid use data, modelled from pharmacy dispensing data, and hospital-treated pneumonia were retrieved from nationwide registers. Patients with active cancer treatment were excluded. Hazard models compared opioid users to nonusers, adjusting for comorbidities, socioeconomic position. and other drug use. Results: Incident opioid use was associated with an increased risk of hospital-treated pneumonia compared to nonuse (adjusted HR, aHR 1.34, 95% CI 1.14–1.57). Highest risk was observed during the first two months of use (aHR 2.58, 95% CI 1.87–3.55). Compared to weak opioids, buprenorphine was not associated with a higher risk of pneumonia (aHR 1.20, 95% CI 0.83–1.76), but strong opioids were (aHR 1.84, 95% CI 1.15–2.97). The risk was higher for those using ≥50 morphine milligram equivalents (MME)/day (aHR 2.03, 95% CI 1.24–3.31), compared to using <50 MME/day. Conclusions: Opioid use was associated with a risk of hospital-treated pneumonia in a dose-dependent manner among persons with AD. Risk-minimization strategies should be considered if opioid therapy is needed.
Repetitive Transcranial Magnetic Stimulation Induced Hypoconnectivity Within the Default Mode Network Yields Cognitive Improvements in Amnestic Mild Cognitive Impairment: A Randomized Controlled Study
Authors: Cui Hailun , Ren Rujing , Lin Guozhen , Zou Yang , Jiang Lijuan , Wei Zhengde , Li Chunbo , Wang Gang 
Published: May 2019

Background: Repetitive transcranial magnetic stimulation (rTMS) is thought to be effective in alleviating cognitive symptoms in patients with amnestic mild cognitive impairment (aMCI), but the mechanisms related to network modification are poorly understood. Objective: Here we tested rTMS efficacy and explored the effect of rTMS-induced changes in the default mode network (DMN) and their predictive value for treatment response. Methods: Twenty-one subjects clinically diagnosed with aMCI were recruited to complete a 10-session randomized and sham-controlled rTMS treatment targeting the right dorsolateral prefrontal cortex. Resting-state functional magnetic resonance imaging in tandem with neuropsychological assessments were administered before and after the intervention. Changes in functional connectivity of the DMN and relevant brain regions, as well as the correlations between baseline functional connectivity and clinical rating scales were calculated in order to elucidate the mechanism of treatment response to rTMS therapy. Results: Compared to the sham group, the rTMS group achieved improvement of neuropsychological performance and significant functional connectivity changes within the DMN. Group×Time interactions were found between posterior cingulate gyrus and right fusiform gyrus (F (1,19)  = 17.154, p = 0.001), and also left anterior cingulate gyrus (F (1,19)  = 3.908, p = 0.063), showing an rTMS-induced deactivation of functional connectivity within the DMN. Baseline functional connectivity analysis of seeds within the DMN in the rTMS group revealed negative correlation with AVLT-Recognition score changes. Conclusion: rTMS-induced hypoconnectivity within DMN is associated with clinical cognitive improvements in patients with aMCI. Further, pre-rTMS baseline activity of the DMN at rest may be a predictor for favorable rTMS treatment response.
Dysregulation of BDNF in Prefrontal Cortex in Alzheimer’s Disease
Authors: Aarons Toby , Bradburn Steven , Robinson Andrew , Payton Antony , Pendleton Neil , Murgatroyd Chris 
Published: May 2019

Background: Brain-derived neurotrophic factor (BDNF) is essential for neurogenesis and has been implicated in Alzheimer’s disease (AD). However, few studies have investigated together the epigenetic, transcriptional, and translational regulation of this peptide in the brain in relation to AD. Objective: To investigate mechanisms underlying how BDNF is possibly dysregulated in the brain in relation to aging and AD neuropathology. Methods: Prefrontal cortex tissues were acquired from the Manchester Brain Bank (N = 67). BDNF exon I, and exon IV-containing transcripts and total long 3’ transcript gene expression were determined by quantitative PCR and bisulfite pyrosequencing was used to quantify DNA methylation within promoters I and IV. Protein concentrations were quantified via ELISA. Results: BDNF exon IV and total long 3’ isoform gene expression levels negatively associated with donor’s age at death ( IV: r = –0.291, p = 0.020; total: r = –0.354, p = 0.004). Expression of BDNF exon I- containing isoform was significantly higher in Met-carriers of the rs6265 variant, compared to Val-homozygotes, when accounting for donor ages (F = 6.455, p = 0.014). BDNF total long 3’ transcript expression was significantly lower in those with early AD neuropathology, compared to those without any neuropathology ( p = 0.021). There were no associations between BDNF promoter I and IV methylation or protein levels with ages, rs6265 genotype or AD neuropathology status. Conclusion: Prefrontal cortex BDNF gene expression is associated with aging, rs6265 carrier status, and AD neuropathology in a variant-specific manner that seems to be independent of DNA methylation influences.
δ Scores Identify Subsets of “Mild Cognitive Impairment” with Variable Conversion Risks
Authors: Royall Donald R. , Palmer Raymond F. 
Published: May 2019

Background: The latent variable “ δ” (for “dementia) is a transdiagnostic measure of dementia severity. δ can be reified and applied to individuals as a composite “d-score”. Like Spearman’s general intelligence factor “ g”, δ can be constructed from almost any cognitive battery. So many are available that we must further distinguish each composite as a δ “homolog”. Fourteen have been validated. All are strongly associated with dementia severity and potentially with mild cognitive impairment (MCI) conversion. Objectives: To assess δ’s impact on MCI conversion risk. Methods: A new δ homolog (dDx) was constructed in 1,230 Mexican-American (MA) and 2,215 non-Hispanic White (NHW) participants in the Texas Alzheimer’s Research and Care Consortium (TARCC). 1,445 normal controls (NC) and 723 MCI were followed annually for up to 6 years. Results: Each SD decrease in the dDx score increased the risk of conversion sixteen-fold [OR = 16.39 (CI: 5.0–52.6)]. Cases below the optimal diagnostic threshold for Alzheimer’s disease (AD) versus NC were labeled as having a functionally salient cognitive impairment (FSCI). Such cases were at a 73-fold increase risk of a diagnosis of AD [OR = 73.19 (95% CI: 58.3–92.0)]. However, 25.6% of MCI cases were also FSCI(+). They accounted disproportionately for prospective conversions. Age <80 years, the absence of an ɛ4 allele, <12 years of education, and MA ethnicity independently increased the risk of diagnosing FSCI as MCI. Conclusion: A sizable minority of MCI cases may be misdiagnosed and they account disproportionately for AD conversions.