bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: miR‐145 promotes miR‐133b expression through c‐myc and DNMT3A‐mediated methylation in ovarian cancer cells
Authors: Li Jie , Zhang Songlin , Zou Yuliang , Wu Lei , Pei Meili , Jiang Yu 
Published: October 2019

AbstractOvarian cancer presents as malignant tumors in the female reproductive system with high mortality. MicroRNAs are involved in the progression of ovarian cancer; however, the regulatory relationship among miRs remains unclear. In our study, we verified that both miR‐145 and miR‐133b messenger RNA (mRNA) levels in ovarian cancer tissues were lower than in normal ovarian tissues, and their mRNA level in serum of patients with ovarian cancer was reduced. We demonstrated miR‐145 targeted c‐myc, and c‐myc interacted physically with DNMT3A in ovarian cancer cells. We confirmed that c‐myc recruited DNMT3A to the miR‐133b promoter. miR‐133b overexpression also inhibited target gene PKM2 expression along with the Warburg effect. Our results indicate that miR‐145 inhibited the Warburg effect through miR‐133b/PKM2 pathways, which may improve approaches to ovarian cancer diagnosis and treatment.
Optimization of ethyl lactate‐based organosolv process for lignin recovery from the solid waste of a wheat straw biorefinery
Authors: Valdespino‐Rodríguez Ángeles , Pérez‐Martín Daín JA , González‐Barajas María Fernanda , Villicaña‐Ambriz Héctor , Campos‐Castellanos Diana , Escalante Froylán ME , Sánchez Arturo , Aguilar‐Garnica Efrén 
Published: October 2019

AbstractBACKGROUNDThe organosolv process promotes biomass delignification at relatively high temperatures using a wide variety of organic solvent solutions. Nevertheless, previous studies on organosolv processes have not dealt with the use of ethyl lactate as organic solvent. Thus the aim of the present contribution was to determine and to validate if the use of ethyl lactate has a positive influence on lignin recovery for organosolv processes whose feedstock is the solid waste from a wheat straw‐based biorefinery. The effect of operating conditions (temperature and time) on lignin recovery was also studied.RESULTSA mixed design of experiments was proposed as the strategy to maximize lignin recovery. The mathematical model derived from a multiple linear regression applied to the mixed design results indicates that 190 °C and a non‐aqueous solution containing ethyl lactate and ethanol (81.2% w/w ethyl lactate) could provide a maximum lignin recovery of 75.9% w/w. This theoretical maximum was validated. Thus the proposed model adequately describes the behavior of lignin recovery. Moreover, Fourier transform infrared (FTIR) characterization of the resultant lignin suggested that its structure is a function of the organic solvent solution used during the organosolv process.CONCLUSIONThe evidence from this study indicates that lignin recovery from the solid waste of a wheat straw‐based biorefinery in an organosolv process depends on temperature and ethyl lactate presence in the reaction medium. These findings enhance the understanding of organosolv processes and could be applied if eventual lignin valorization is desired. © 2019 Society of Chemical Industry
Synthesis, characterization & in vitro antimicrobial‐antioxidant studies of novel N,1‐diphenyl‐4,5‐dihydro‐1H‐1,2,4‐triazol‐3‐amine derivatives
Authors: Yusuf Mohamad , Thakur Saloni 
Published: October 2019

AbstractA new series of 1,2,4‐triazole was designed, synthesized, and characterized as remarkable antimicrobial and antioxidant agents. These heterocycles have been prepared from the cyclization reactions of Schiff bases 3(a‐k) with phenylhydrazine by refluxing under the alkaline medium. The Schiff bases in turn were realized in good yields from the condensation reactions of N‐phenylurea with different aromatic aldehydes. The structures of the intermediates 3(a‐k) and final heterocycles 4(a‐k) have been fully characterized through their spectral parameters.
Subacute feeding toxicity of low‐sodium sausages manufactured with sodium substitutes and biopolymer‐encapsulated saltwort (Salicornia herbacea) in a mouse model
Authors: Jung Eun Young , Lee Da Young , Kim On You , Lee Seung Yun , Yim Dong Gyun , Hur Sun Jin 
Published: October 2019

AbstractBACKGROUNDLow‐sodium sausages were manufactured using sodium substitution and biopolymer encapsulation. A diet comprising 10% treatment sausages (six treatment groups: C (100% NaCl), T1 (55% sodium substitute + 45% saltwort salt), T2 (55% sodium substitute + 45% saltwort salt with chitosan), T3 (55% sodium substitute + 45% saltwort salt with cellulose), T4 (55% sodium substitute + 45% saltwort salt with dextrin), and T5 (55% sodium substitute + 45% saltwort salt with pectin)) was added to a 90% commercial mouse diet for 4 weeks.RESULTSSubacute toxicity, hematology, liver function, and organ weight tests in low‐sodium sausage groups showed results similar to those of the control group, and all toxicity test levels were within normal ranges.CONCLUSIONSAll low‐sodium sausage types tested are suggested to be safe in terms of subacute toxicity. Moreover, low‐sodium sausages can be manufactured by biopolymer encapsulation of saltwort using pectin, chitosan, cellulose, and dextrin without toxicity. © 2019 Society of Chemical Industry
Frequency and implications of occipital and posterior auricular sentinel lymph nodes in scalp melanoma
Authors: Carmichael Heather , King Becky B. T. , Friedman Chloe , Torphy Robert J. , Medina Theresa , Gleisner Ana , McCarter Martin D. , Kwak Jennifer J. , Kounalakis Nicole 
Published: October 2019

AbstractBackgroundPatients with scalp melanoma have poor oncologic outcomes compared with those with other cutaneous sites. Sentinel lymph node (SLN) biopsy provides prognostic information but is challenging in the head and neck. We explore the anatomic distribution of scalp melanoma and describe the most common sites of SLN drainage and of SLN metastatic disease.MethodsRetrospective review of scalp melanoma patients who underwent SLN biopsy. Melanoma location was classified as frontal, coronal apex, coronal temporal, or posterior scalp. SLN location was classified by lymph node level and region.ResultsWe identified 128 patients with scalp melanoma. The most common primary tumor location was the posterior scalp (43%) and the most frequent SLN drainage site was the level 2 lymph node basin (48%). Total 31 patients (24%) had metastatic disease in an SLN. Scalp SLNs, classified as being in the posterior auricular or occipital region, were localized in 26% of patients. For patients in which a scalp SLN was identified, 30% had a positive scalp SLN (n = 10).ConclusionsScalp SLNs are frequent drainage sites for scalp melanoma and, when found, have a 30% chance of harboring metastatic disease. Surgeons, radiologists, and pathologists should be vigilant in identifying, removing, and analyzing scalp SLNs.
Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors
Authors: Kasai Yosuke , Mahuron Kelly , Hirose Kenzo , Corvera Carlos U. , Kim Grace E. , Hope Thomas A. , Shih Brandon E. , Warren Robert S. , Bergsland Emily K. , Nakakura Eric K. 
Published: October 2019

AbstractBackground and ObjectivesIleal neuroendocrine tumors (i‐NETs) frequently metastasize to mesenteric lymph nodes and the liver. Regional lymphadenopathy is associated with desmoplasia of the mesentery forming a large mesenteric mass (LMM). Although the latest American Joint Committee on Cancer TNM staging (8th edition) defined LMM >2 cm as N2, the prognostic impact of LMM is ill‐defined. We evaluated whether LMM is prognostic for patients with i‐NETs.MethodsThis single‐institution, retrospective cohort study included 106 patients who underwent resection of i‐NETs between 2007 and 2018. Overall survival (OS) and liver progression‐free survival (LPFS) were compared between patients with and without LMM.ResultsLMM was present in 66 patients (62%) and was not associated with the presence or absence of liver metastasis (P = .969) or the extent of liver involvement (P = .938). OS and LPFS differed significantly between patients with and without LMM (5‐year OS rates of 64.8% and 92.9%, respectively, P = .011; 3‐year LPFS rates of 45.3% and 67.5%, respectively, P = .025). In multivariate analysis, LMM was an independent prognostic factor for both OS (hazard ratio: 4.69, 95% confidence interval: 1.63‐17.6) and LPFS (1.99, 1.08‐3.88).ConclusionLMM >2 cm is prognostic for OS and LPFS and represents aggressive tumor biology.
Exclusive use of ultrasound for locating optimal LVA sites—A descriptive data analysis
Authors: Czedik‐Eysenberg Manon , Steinbacher Johannes , Obermayer Brigitte , Yoshimatsu Hidehiko , Hara Hisako , Mihara Makoto , Tzou Chieh‐Han J. , Meng Stefan 
Published: October 2019

AbstractBackgroundThe current standard to locate lymphatic vessels for lymphovenous anastomosis (LVA) is the use of indocyanine green (ICG)‐lymphangiography. Due to fluid retention and fibrosis of tissue in patients with lymphedema, often present in Caucasian patients, vessels deeper than 0.5 cm below the dermis cannot be visualized. We present our experiences with ultrasound in locating deeper lymphatic vessels in lower extremities.Materials and MethodsIn total, 28 patients with lymphedema and positive lymphoscintigraphy were included. With ultrasound, we located 82 lymphatic vessels in lower extremities preoperatively without the use of ICG marking. Vessel diameter, depth, and exact location were examined. Using a coordinate system, a mapping of the detected lymphatic vessels was created. The ultrasound findings were confirmed under microscope and ICG intraoperatively.ResultsIn all, we detected 28 Caucasian patients and 82 lymphatic vessels with ultrasound preoperatively. On average, we found three lymphatic vessels (range, 2‐6) at each patient. Of the ultrasound‐detected lymphatic vessels, 90.2% could be verified intraoperatively under a microscope. Before skin incision, lymphatic vessels could be visualized in 40% of our patients with ICG. In the mapping of the lymphatic vessels, we found no significant pattern.ConclusionUltrasound can precisely detect lymphatic vessels for efficient LVA operation without the prior use of ICG‐lymphangiography.
Fatigue management for adults living with HIV: A randomized controlled pilot study
Authors: Lee Kathryn A. , Jong SoSon , Gay Caryl L. 
Published: October 2019

AbstractFatigue is a prevalent symptom for adults living with HIV infection. The purpose of this randomized clinical trial was to pilot test a behavioral‐educational intervention to reduce fatigue. The intervention included education about daytime behaviors as well as nighttime sleep behaviors. Participants were HIV‐positive, between 45 and 75 years old, unemployed, and experiencing fatigue. They were randomized to intervention (n = 25) or control (n = 26) after obtaining baseline measures, administered the intervention or attention control, and followed with monthly assessments for 3 months. Primary outcome measures included the Fatigue Severity Scale (FSS) and fatigue symptom burden using the four‐dimension structure of the Memorial Symptom Assessment Scale that includes occurrence, frequency, severity, and distress of a symptom. Other measures included the International Physical Activity Questionnaire, step counts with a Fitbit Flex, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, and Sleep Behavior Rating Scale. Compared with attention controls, the intervention group had significantly (p < .05) lower FSS scores and fatigue symptom burden over time, particularly in the frequency dimension. Secondary outcomes for reducing daytime naps and improving sleep quality were also significant (p < .05). This intervention, focused on both daytime and nighttime behaviors, demonstrated promising effects for reducing fatigue among adults living with HIV. Results provide useful direction for larger clinical trials to reduce fatigue in adults living with other types of chronic illness.
The ganglioside GD2 as a circulating tumor biomarker for neuroblastoma
Authors: Balis Frank Milton , Busch Christine Maria , Desai Ami Vijay , Hibbitts Emily , Naranjo Arlene , Bagatell Rochelle , Irwin Meredith , Fox Elizabeth 
Published: October 2019

AbstractBackgroundGD2 is a ganglioside that is ubiquitously expressed in the plasma membrane of neuroblastoma and is shed into the circulation.ProcedureGD2 was measured with a high‐pressure liquid chromatography/tandem mass spectrometry assay in serum or plasma from 40 children without cancer (controls) and in biobanked samples from 128 (73 high‐risk) children with neuroblastic tumors at diagnosis, 56 children with relapsed neuroblastoma, 14 children with high‐risk neuroblastoma after treatment, and 8 to 12 children each with 10 other common childhood cancers at diagnosis.ResultsThe C18 (18 carbon fatty acid) lipoform was the predominant circulating form of GD2 in controls and in patients with neuroblastoma. The median concentration of GD2 in children with high‐risk neuroblastoma at diagnosis was 167 nM (range, 16.1‐1060 nM), which was 30‐fold higher than the median concentration (5.6 nM) in controls. GD2 was not elevated in serum from children with the differentiated neuroblastic tumors, ganglioneuroma (n = 10) and ganglioneuroblastoma‐intermixed subtype (n = 12), and in children with 10 other childhood cancers. GD2 concentrations were significantly higher in serum from children with MYCN‐amplified tumors (P = 0.0088), high‐risk tumors (P < 0.00001), International Neuroblastoma Staging System (INSS) stage 4 tumors (P < 0.00001), and in children who died (P = 0.034).ConclusionsCirculating GD2 appears to be a specific and sensitive tumor biomarker for high‐risk/high‐stage neuroblastoma and may prove to be clinically useful as a diagnostic or prognostic circulating tumor biomarker. GD2 will be measured prospectively and longitudinally in children enrolled on a high‐risk neuroblastoma treatment trial to assess its ability to measure response to treatment and predict survival.
A three‐dimensional potential of mean force to improve backbone and sidechain hydrogen bond geometry in Xplor‐NIH protein structure determination
Authors: Schwieters Charles D. , Bermejo Guillermo A. , Clore G. Marius 
Published: October 2019

AbstractWe introduce a new hydrogen bonding potential of mean force generated from high‐quality crystal structures for use in Xplor‐NIH structure calculations. This term applies to hydrogen bonds involving both backbone and sidechain atoms. When used in structure refinement calculations of 10 example protein systems with experimental distance, dihedral and residual dipolar coupling restraints, we demonstrate that the new term has superior performance to the previously developed hydrogen bonding potential of mean force used in Xplor‐NIH.
Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing
Authors: Kallmeyer Karlien , André-Lévigne Dominik , Baquié Mathurin , Krause Karl-Heinz , Pepper Michael S. , Pittet-Cuénod Brigitte , Modarressi Ali 
Published: October 2019

Abstract
There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed.

Significance statement The exogenous administration of adipose-derived mesenchymal stromal cells (ASCs) holds promise as a treatment strategy for wound healing by promoting tissue repair and regeneration. However, the best route of administration is still not well defined. Herein, this article describes the biodistribution and survival of systemically vs locally administered ASCs. Interestingly, both routes of administration led to enhanced wound repair as seen by earlier wound closure. Systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs, whereas locally administered ASCs migrate into the wound bed.
Maternal arterial stiffness in hypertensive pregnancies with and without small‐for‐gestational‐age neonate
Authors: Perry H. , Gutierrez J. , Binder J. , Thilaganathan B. , Khalil A. 
Published: October 2019

ABSTRACTObjectivePregnancies complicated by pre‐eclampsia with a small‐for‐gestational‐age (SGA) neonate have poorer maternal hemodynamic function compared to those with hypertensive disorders of pregnancy (HDP) and an appropriately grown neonate. Arterial stiffness is a recognized prognostic marker of cardiovascular disease in the general population. The aim of this study was to compare maternal arterial stiffness between hypertensive pregnancies with, and those without, a SGA neonate and normotensive control pregnancies.MethodsThis was a prospective cohort study of pregnancies complicated by pre‐eclampsia or gestational hypertension and healthy normotensive control pregnancies, presenting to a tertiary referral hospital between January 2012 and May 2018. Maternal arterial stiffness was assessed by aortic pulse‐wave velocity (PWV) and aortic augmentation index (AIx), which were recorded using a non‐invasive device (Arteriograph®). Maternal and hemodynamic factors were adjusted for using linear regression analysis. Pregnancies with HDP were divided into those that delivered a SGA (birth weight < 10th percentile) neonate (HDP + SGA group) and those that delivered an appropriately grown neonate (HDP‐only group). Comparisons between groups were carried out using the Mann–Whitney U‐test for continuous variables and the chi‐square (or Fisher's exact) test for categorical variables.ResultsIncluded in the analysis were 69 patients with HDP who delivered a SGA neonate, 129 with HDP who delivered a normally grown neonate and 220 healthy controls. Maternal age, weight, height and heart rate were associated significantly with brachial and aortic AIx. Maternal weight, height, mean arterial pressure, heart rate and gestational age were significant predictors of aortic PWV. Adjusted aortic AIx was significantly higher in both the HDP + SGA and HDP‐only groups, compared with in controls (12.5% and 10.0% vs 7.6%; both P < 0.01), and was significantly different between the two HDP groups (P = 0.002). Adjusted PWV was significantly higher in the HDP‐only group compared with in controls and the HDP + SGA group (7.7 m/s vs 7.1 m/s and 7.1 m/s; both P < 0.001). Conversely, unadjusted PWV was not significantly different between the two HDP groups (P = 0.414).ConclusionsPregnancies complicated by HDP with, and those without, a SGA neonate have significantly higher aortic AIx compared with uncomplicated normotensive pregnancies. Aortic AIx was highest in those pregnancies complicated by HDP with a SGA neonate, reflecting a progression in severity of arterial stiffness abnormality with a worsening clinical picture. These findings most likely reflect systemic reduced vascular compliance and increased systemic vascular resistance in pregnancy complicated by
HDP. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
What Have They Done to My Song? Recycled Language in Monika Fagerholm’s The American Girl
Authors: Tidigs Julia 
Published: October 2019

AbstractThe chapter explores intermedial references and linguistic spatiality through an analysis of Finland-Swedish author Monika Fagerholm’s novel Den amerikanska flickan/The American Girl (2004/2009). Fagerholm’s extensive use of translated phrases borrowed from songs and poetry in English that she repeats with variation highlights the collective nature of language, as well as continuous linguistic variation. The “multilingual soundscape” that is thus created for each reader, depending on his or her recognition of the borrowed and translated phrases, is contextualized in relation to Rebecca L. Walkowitz’s concept of born-translated literature. The chapter also argues that the constantly highlighted “transatlantic” quality of Fagerholm’s language entails a dislodgment of the fixed spatial anchoring of language in nationalist language ideology.
Factorisation of quasi K-matrices for quantum symmetric pairs
Authors: Dobson Liam , Kolb Stefan 
Published: October 2019

AbstractThe theory of quantum symmetric pairs provides a universalK-matrix which is an analog of the universalR-matrix for quantum groups. The main ingredient in the construction of the universalK-matrix is a quasiK-matrix which has so far only been constructed recursively. In this paper we restrict to the cases where the underlying Lie algebra is$$\mathfrak {sl}_n$$slnor the Satake diagram has no black dots. In these cases we give an explicit formula for the quasiK-matrix as a product of quasiK-matrices for Satake diagrams of rank one. This factorisation depends on the restricted Weyl group of the underlying symmetric Lie algebra in the same way as the factorisation of the quasiR-matrix depends on the Weyl group of the Lie algebra. We conjecture that our formula holds in general.
Imaging of rectal cancer
Authors: Boot J. , Gomez-Munoz F. , Beets-Tan R. G. H. 
Published: October 2019

Abstract
International guidelines dictate that magnetic resonance imaging (MRI) should be part of the primary standard work up of patients with rectal cancer because MRI can accurately identify the main risk factors for local recurrence and stratify patients into a differentiated treatment. The role of endoscopic ultrasound (EUS) is restricted to staging of superficial tumors because EUS is able to differentiate between T1 and T2 rectal cancer. Recent guidelines recommend the addition of diffusion-weighted (DWI) MRI to clinical and endoscopic assessment of response to preoperative radiochemotherapy (RCT). MRI is able to identify significant tumor regression which may alter the surgical approach.