bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury in vitro by targeting BIK
Authors: Chen Xuelin , Li Caixia , Li Jianghao , Sheng Luoping , Liu Xianglu 
Published: August 2019

ABSTRACT
MiR-1306-5p is involved in the progression of acute heart failure, but its role in ischemic stroke remains unclear. Here, SH-SY5Y cells were exposed to oxygen–glucose deprivation (OGD) for 4, 8, and 12 h, respectively, and then reoxygenation for 12 h to construct OGD/R induced cell injury model. Cell viability, cell death, and cell apoptosis were assessed with CCK-8 assay, LDH assay, ﬂow cytometry, and caspase-3 activity assay. The target gene of miR-1306-5p was confirmed by luciferase reporter assay. We found miR-1306-5p expression was significantly down-regulated in OGD/R-induced SH-SY5Y cell model. Moreover, miR-1306-5p protected SH-SY5Y cell against OGD/R-induced injury. Mechanistically, Bcl2-interacting killer (BIK) was the direct target gene of miR-1306-5p. Furthermore, BIK knockdown mimicked, while overexpression reversed the protective effects of miR-1306-5p against OGD/R induced injury. Our findings thus provide an experimental basis miR-1306-5p targeting BIK-based therapy for cerebral I/R injury.
Portable PSG for sleep stage monitoring in sports: Assessment of SOMNOwatch plus EEG
Authors: Hof Zum Berge Annika , Kellmann Michael , Kallweit Ulf , Mir Shakila , Gieselmann Annika , Meyer Tim , Ferrauti Alexander , Pfeiffer Mark , Kölling Sarah 
Published: August 2019

AbstractCurrent sport‐scientific studies mostly neglect the assessment of sleep architecture, although the distribution of different sleep stages is considered an essential component influencing an athlete's recovery and performance capabilities. A mobile, self‐applied tool like the SOMNOwatch plus EEG might serve as an economical and time‐friendly alternative to activity‐based devices. However, self‐application of SOMNOwatch plus EEG has not been validated against conventional polysomnography (PSG) yet. For evaluation purposes, 25 participants (15 female, 10 male; M age = 22.92 ± 2.03 years) slept in a sleep laboratory on two consecutive nights wearing both, conventional PSG and SOMNOwatch plus EEG electrodes. Sleep parameters and sleep stages were compared using paired t‐tests and Bland–Altman plots. No significant differences were found between the recordings for Sleep Onset Latency, stages N1 to N3 as well as Rapid Eye Movement stage. Significant differences (Bias [95%‐confidence interval]) were present between Total Sleep Time (9.95 min [−29.18, 49.08], d = 0.14), Total Wake Time (−13.12 min [−47.25, 23.85], d = −0.28), Wake after Sleep Onset (−11.70 min [−47.25, 23.85], d = −0.34) and Sleep Efficiency (2.18% [−7.98, 12.34], d = 0.02) with small effect sizes. Overall, SOMNOwatch plus EEG can be considered a valid and practical self‐applied method for the examination of sleep. In sport‐scientific research, it is a promising tool to assess sleep architecture in athletes; nonetheless, it cannot replace in‐lab PSG for all clinical or scientific purposes.
Adaptation and Adaptability: Multiple Authors and Studio Authorship in SoulMate
Authors: Sun Yi 
Published: August 2019

AbstractThis article examines a China-Hong Kong co-produced film adaptation, SoulMate, within sociocultural, industrial, and organizational contexts. It argues that, first, the film adaptation’s authors are not limited to the agents who adapt the source material. The production company explores and exploits a variety of authors, including extrinsic names to the work, as symbolic resources to serve the discourse surrounding the film; and the adaptation status makes a special contribution to that process by multiplying authors and by generating cross-references. Second, film adaptation has a specific and significant bearing on the adaptability of production houses that encounter changing sociocultural and industrial environments. This article hopefully broadens the understanding of film adaptation in alternative historical periods and industrial contexts other than Hollywood with a simultaneous effort to propose new approaches to the study of Chinese-language film adaptation. It also attempts to expand the discourse of authorship in film adaptation studies and in film studies more generally by identifying filmmaking entities, in addition to directors, producers, and writers, as adaptive co-authors and non-conflicting stakeholders in the business of film adaptation.
Sex differences in migratory restlessness behavior in a Nearctic–Neotropical songbird
Authors: Deakin Jessica E , Guglielmo Christopher G , Morbey Yolanda E 
Published: August 2019

Abstract
Most seasonally migrating songbirds exhibit protandry, whereby males arrive to breeding sites in the spring before females. The proximate behavioral mechanisms of protandry are largely unknown for most species, but could include earlier migratory departure from wintering sites by males or overall faster migration by males. Using onset and intensity of migratory restlessness as proxies for departure timing and rate of migration, respectively, we evaluated these 2 hypothesized mechanisms in a Nearctic–Neotropical migrating songbird, the Black-throated Blue Warbler (Setophaga caerulescens). Birds were captured during fall migration, held in captivity over winter, and photostimulated in the spring to induce migratory behavior. Video analysis was used to separately quantify stereotypical nocturnal wing whirring and jumping migratory restlessness behaviors. The birds were then radio-tagged and released in mid-May to compare stopover duration between the sexes and validate migratory restlessness in captivity as a proxy for the motivation to migrate in the field. In captivity males initiated migratory restlessness earlier in the spring than females, demonstrating innate differences in the onset of spring migration in this species. Males also displayed higher-intensity wing whirring behavior, suggesting potential sex differences in flight behavior that could influence migration rate. We found no sex differences in stopover duration in the field following release. However, stopover duration was negatively correlated with total migratory restlessness intensity on the last night the birds were held in captivity, which supports migratory restlessness as a proxy for the motivation to migrate at the individual level.
Nonbreeding season movements of a migratory songbird are related to declines in resource availability
Authors: Knight Samantha M , Gow Elizabeth A , Bradley David W , Clark Robert G , Bélisle Marc , Berzins Lisha L , Blake Tricia , Bridge Eli S , Burke Lauren , Dawson Russell D , Dunn Peter O , Garant Dany , Holroyd Geoffrey L , Hussell David J T , Lansdorp Olga , Laughlin Andrew J , Leonard Marty L , Pelletier Fanie , Shutler Dave , Siefferman Lynn , Taylor Caz M , Trefry Helen E , Vleck Carol M , Vleck David , Whittingham Linda A , Winkler David W , Norris D Ryan 
Published: August 2019

AbstractThere have been an increasing number of observations of itinerancy in migratory songbirds, where individuals move among 2 or more widely separated areas during the “stationary” nonbreeding season. Knowledge of such movements and an understanding of what drives them are important for predicting how migratory populations will respond to environmental change. In this study, we investigated nonbreeding movements of the Tree Swallow (Tachycineta bicolor), an aerial insectivore that breeds across North America and spends the nonbreeding season around the Gulf of Mexico, Florida, Mexico, Central America, and the Caribbean. With year-round tracking data obtained from 133 light-level geolocators deployed at 12 breeding sites ranging from Alaska to Nova Scotia to North Carolina, we show that 44% of individuals made at least one large-scale movement (range: 301–1,744 km) within the nonbreeding range. The frequency of itinerancy decreased with longitude, such that 75% of individuals made a movement in the western portion of the nonbreeding range compared to only 31% in the east. Using the Normalized Difference Vegetation Index (NDVI) as a proxy for resource availability, we found that when individuals did move, they were more likely to move from sites where resources were deteriorating faster (a more negative change in NDVI prior to departure) than their destination sites. There was also evidence that individuals moved to destination sites with higher NDVI and temperature in the autumn, but not in the winter. Our results suggest movements of Tree Swallows during the nonbreeding season are influenced by resource availability, but because not all individuals used multiple nonbreeding sites, the density of individuals at a site and the level of competition may have also been a factor influencing nonbreeding season movements.
Minimal dispersion approximately balancing weights: asymptotic properties and practical considerations
Authors: Wang Yixin , Zubizarreta Jose R 
Published: August 2019

Summary
Weighting methods are widely used to adjust for covariates in observational studies, sample surveys, and regression settings. In this paper, we study a class of recently proposed weighting methods, which find the weights of minimum dispersion that approximately balance the covariates. We call these weights ‘minimal weights’ and study them under a common optimization framework. Our key observation is that finding weights which achieve approximate covariate balance is equivalent to performing shrinkage estimation of the inverse propensity score. This connection leads to both theoretical and practical developments. From a theoretical standpoint, we characterize the asymptotic properties of minimal weights and show that, under standard smoothness conditions on the propensity score function, minimal weights are consistent estimates of the true inverse probability weights. In addition, we show that the resulting weighting estimator is consistent, asymptotically normal and semiparametrically efficient. From a practical standpoint, we give a finite-sample oracle inequality that bounds the loss incurred by balancing more functions of the covariates than strictly needed. This inequality shows that minimal weights implicitly bound the number of active covariate balance constraints. Finally, we provide a tuning algorithm for choosing the degree of approximate balance in minimal weights. The paper concludes with an empirical study which suggests that approximate balance is preferable to exact balance, especially when there is limited overlap in covariate distributions. Further studies show that the root mean squared error of the weighting estimator can be reduced by as much as a half with approximate balance.
Cryptic speciation in the herbaceous bamboo genus Piresia (Poaceae, Olyreae)
Authors: de Carvalho Maria L Silveira , de Jesus Izabela S D , da Silva Rilquer M , Leite Kelly R B , Schnadelbach Alessandra S , Clark Lynn G , de Oliveira R Patrícia 
Published: August 2019

AbstractPiresia, a small genus of herbaceous bamboos, has a geographical disjunction between the Caribbean and northern/western South America and the north-eastern Atlantic Forest in Brazil. Piresia leptophylla is reported from western Amazonia (WA) and the north-eastern Atlantic Forest (NAF), but its occurrence in western Amazonia is questionable. Using an integrative approach, we combined traditional morphological analysis, anatomy and niche modelling. The results revealed few macromorphological differences between WA and NAF specimens (only plant height, leaf length, lodicule dimensions, shape and position), contrasting with consistent differences in leaf anatomy (macrohairs and cruciform silica bodies in the costal zone of the adaxial/abaxial leaf surfaces, crenate silica bodies on the abaxial leaf surface, lack of panicoid hairs on the abaxial leaf surface, bicellular microhairs and lobed papillae over the abaxial leaf surface, and sparse but elongated fusoid cells in the mesophyll of WA specimens) and in niche patterns. The anatomical/micromorphological characters suggest environmental adaptations to the Amazonian and ‘restinga’ forests, respectively. We therefore propose the segregation of the WA populations into a new species, Piresia tenella sp. nov. We provide a formal description, photographs, a line illustration, a distribution map and discussion of the conservation status for the new species.
The chaos of hypertension guidelines for chronic kidney disease patients
Authors: Castillo-Rodriguez Esmeralda , Fernandez-Fernandez Beatriz , Alegre-Bellassai Raquel , Kanbay Mehmet , Ortiz Alberto 
Published: August 2019

Abstract
Three major guidelines deal with blood pressure thresholds and targets for antihypertensive drug therapy in chronic kidney disease (CKD) patients: the 2012 Kidney Disease: Improving Global Outcomes Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease; the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults; and the 2018 ESC/ESH Guidelines for the Management of Arterial Hypertension. However, a careful reading of the three guidelines leaves the practicing physician confused about the definition of CKD, how hypertension and secondary hypertension should be diagnosed in CKD patients and what the blood pressure thresholds, targets and compelling indications of antihypertensive drug therapy should be for this population. Current guidelines refer to different CKD populations and propose different definitions of hypertension, different thresholds to initiate antihypertensive therapy in CKD patients and different BP targets compelling antihypertensive drug use. The different bodies producing guidelines should work together towards a unified definition of CKD, a unified concept of hypertension and unified BP thresholds and targets for hypertensive drug therapy for CKD patients. Otherwise they risk promoting confusion and therapeutic nihilism among physicians and patients.
Treatment of idiopathic membranous nephropathy in adults: KDIGO 2012, cyclophosphamide and cyclosporine A are out, rituximab is the new normal
Authors: Rojas-Rivera Jorge Enrique , Carriazo Sol , Ortiz Alberto 
Published: August 2019

AbstractThe 2012 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines for glomerulonephritis shed light on the complex world of glomerulonephritis therapy. However, they may no longer apply to idiopathic membranous nephropathy, as recently concluded by the KDIGO 2019 Working Group. This is due to the discovery of autoantibodies such as anti-phospholipase A2 receptor (anti-PLA2R) that allow disease monitoring as well as to results from recent clinical trials, comparative cohort studies and meta-analyses. Perhaps the most disruptive of them is the Membranous Nephropathy Trial of Rituximab (MENTOR) trial comparing rituximab with cyclosporine A, which supports the superiority of rituximab in efficacy and safety. Furthermore, rituximab results compared favourably with the short-term results of classical clinical trials that supported the KDIGO 2012 recommendation of immunosuppressive cyclophosphamide-based regimens as first choice for active treatment of idiopathic membranous nephropathy. Thus, the KDIGO recommendations for cyclophosphamide-based regimens or calcineurin inhibitors as the first line of active treatment regimens for idiopathic membranous nephropathy with nephrotic syndrome may no longer apply. By contrast, rituximab-based regimens or other B-cell-targeted therapies appear to represent the present and future of membranous nephropathy therapy.
Post-treatment mortality after definitive chemoradiotherapy versus resection for esophageal cancer
Authors: Jiang W , Verma V , Haque W , Moreno A C , Koshy M , Butler E B , Teh B S 
Published: August 2019

SUMMARY
In efforts to better characterize incidence and predictors of 30- and 90-day mortality following operative versus nonoperative approaches for locally advanced esophageal cancer (EC), we conducted a novel investigation of a large, contemporary US database. The National Cancer Database was queried for newly-diagnosed T1–3N0–1 squamous cell or adenocarcinoma receiving surgical-based therapy (esophagectomy alone or preceded by chemotherapy and/or radiotherapy) versus definitive chemoradiotherapy (dCRT). Statistics included graphing cumulative incidences of mortality before and following propensity score matching (PSM), based on age-based intervals. Cox regression determined factors independently predictive of 30- and 90-day mortality. Of 15,585 patients, 9,278 (59.5%) received surgical-based therapy and 6,307 (40.5%) underwent dCRT. In the unadjusted population, despite nonsignificant differences at 30 days (3.3% dCRT, 3.6% surgical-based), the dCRT cohort experienced higher 90-day mortality (11.0% vs. 7.5%, P &lt; 0.001). Following PSM, however, dCRT patients experienced significantly lower 30-day mortality (P &lt; 0.001), with nonsignificant differences at 90 days (P = 0.092). Surgical-based management yielded similar (or better) mortality as dCRT in ≤70-year-old patients; however, dCRT was associated with reduced mortality in subjects &gt; 70 years old. In addition to the intervention group, factors predictive for 30- and 90-day mortality included age, gender, insurance status, facility type, comorbidity index, tumor location, histology, and T/N classification. In summary, surgical-based therapy for EC is associated with higher 30-day mortality, which becomes statistically similar to dCRT by 90 days. Differences between surgery and dCRT were most pronounced in patients &gt; 70 years of age. These data may better inform shared decision-making between multidisciplinary providers and patients.
Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report
Authors: Toya Takumi , Kagami Kazuki , Adachi Takeshi 
Published: August 2019

Abstract

Background
Although aspirin and adrenaline are the guideline-recommended treatments for acute coronary syndrome (ACS) and anaphylaxis, both regimens can contribute to clinical worsening in the setting of concurrent ACS and anaphylaxis which is called allergic angina or Kounis syndrome.

Case summary
A 62-year-old woman with food-dependent exercise-induced anaphylaxis developed ACS after intramuscular injection of adrenaline for the treatment of anaphylaxis, whereas administered aspirin for the treatment of ACS exacerbated anaphylaxis.

Discussion
Our case underlines the importance of tailored treatment based on the underlying pathophysiology of individual patients. Clopidogrel and glucagon might be a better alternative for the treatment of Kounis syndrome.
A minimally invasive all-in-one approach for patients with left anterior descending artery disease and atrial fibrillation
Authors: Maesen Bart , La Meir Mark , Luermans Justin , Segers Patrique 
Published: August 2019

Abstract
The efficacy and safety of thoracoscopic atrial fibrillation (AF) ablation and minimally invasive direct coronary artery bypass grafting have been previously reported. Herein, we describe the successful combination of both procedures in a high-risk patient with symptomatic drug-refractory paroxysmal AF and a proximal left main stenosis. This innovative procedure offers patients an all-in-one, truly minimally invasive approach to treat AF and left anterior descending artery disease. Based on our initial experience, the procedure is safe and feasible.
Ticagrelor-based antiplatelet regimens in patients treated with coronary artery bypass grafting: a meta-analysis of randomized controlled trials
Authors: von Scheidt Moritz , Bongiovanni Dario , Tebbe Ulrich , Nowak Bernd , Stritzke Jan , Zhao Qiang , Zhu Yunpeng , Kastrati Adnan , Cassese Salvatore , Schunkert Heribert 
Published: August 2019

Abstract

OBJECTIVES
The optimal antiplatelet strategy in patients undergoing CABG remains unclear. This is the first meta-analysis investigating the clinical outcomes associated with ticagrelor-based antiplatelet regimens in patients receiving CABG.

METHODS
Relevant scientific databases were searched for studies investigating antiplatelet regimens after CABG from inception until April 1, 2019. Studies which randomly assigned CABG patients to either ticagrelor-based or control antiplatelet regimens were eligible. The primary outcome of this analysis was all-cause death. The main secondary outcome was MI. Other outcomes of interest were cardiac death, major adverse cardiac events, stroke and bleeding. This study is registered with PROSPERO, number CRD42019122192.

RESULTS
Five trials comprising 3996 patients (2002 assigned to ticagrelor-based and 1994 to control antiplatelet regimens) were eligible for quantitative synthesis. The median follow-up was 12 months. Control antiplatelet regimens consisted of either aspirin or clopidogrel or both. As compared to control, ticagrelor-based regimens reduced the risk of all-cause death [0.61 (0.43–0.87); P = 0.007], cardiac death [0.58 (0.39–0.86); P = 0.007] and major adverse cardiac events [0.79 (0.63–0.98); P = 0.03], without difference in the risk of MI [0.76 (0.50–1.18); P = 0.22], stroke [0.99 (0.56–1.78); P = 0.98] or bleeding [1.04 (0.95–1.14); P = 0.41]. There was a treatment effect modification for the primary outcome associated with trials enrolling predominantly patients with acute coronary syndrome (P for interaction = 0.038).

CONCLUSIONS
In patients receiving CABG, ticagrelor-based regimens reduce mortality and major adverse cardiac events without excess bleeding risk as compared with aspirin monotherapy or the combination of aspirin and clopidogrel. The benefit of ticagrelor-based regimens is more relevant in those studies enrolling predominantly patients with acute coronary syndrome. These findings require further confirmation in randomized trials focused on this subset of patients and powered for clinical outcomes.
Populist Governments and International Law: A Reply to Heike Krieger
Authors: Rudolphy Marcela Prieto 
Published: August 2019

Abstract
In this article, I argue that there are two main objections against Heike Krieger’s view on what ‘a populist approach to international law’ entails. First, there are two methodological obstacles that counsel against constructing ‘a populist approach to international law’: populism varies significantly depending on its definition of ‘the people’ and international law is a fragmented regime. Second, the opposition between a ‘law of coordination’ and a ‘law of cooperation’ to which Krieger resorts is misleading, for it obscures the fact that the value of cooperation and coordination lies primarily in the values for which we coordinate and cooperate. As such, I argue that this opposition may make us partially blind to two important dangers that some forms of populism may pose right now: their cooperating to reshape international law and institutions according to (some) of their values and their refusing to cooperate or coordinate in the achievement of urgent goals. Nonetheless, I conclude that the precise shape of these dangers – as well as how to resist them – remains blurry if we do not pay proper attention to the ways in which different forms of populism define ‘the people’.