bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of social media among health professionals to facilitate chronic disease self-management with their patients: A systematic review
Authors: De Angelis Gino , Wells George A , Davies Barbara , King Judy , Shallwani Shirin M , McEwan Jessica , Cavallo Sabrina , Brosseau Lucie 
Published: May 2018

Objective The objective of this systematic review was to summarize the evidence pertaining to the use of social media by health professionals to facilitate chronic disease self-management with their patients. Methods A systematic approach was used to retrieve and extract relevant data. A total of 5163 citations were identified, of which seven unique studies met criteria for inclusion; one was a randomized controlled trial, two were prospective cohort studies, and four were qualitative studies. The following social media platforms were evaluated: discussion forums (6 studies) and collaborative project (1 study). Results The available evidence suggests that health professionals perceived discussion forums and collaborative projects to be useful social media platforms to facilitate chronic disease self-management with patients. No relevant evidence was found regarding the use of other social media platforms. Most studies indicated positive findings regarding health professionals’ intention to use discussion forums, while the one study that used a collaborative project also indicated positive findings with its perceived ease of use as health professionals felt that it was useful to facilitate chronic disease self-management with patients. Mixed findings were seen in regards to health professionals’ perceived ease of use of discussion forums. The most common barrier to using social media platforms was the lack of time in health professionals’ schedules. Conclusions Discussion forums and collaborative projects appear to be promising resources for health professionals to assist their patients in self-managing their chronic conditions; however, further research comparing various social media platforms is needed.
The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial
Authors: Dore Fiona J. , Domingues Cleyton C. , Ahmadi Neeki , Kundu Nabanita , Kropotova Yana , Houston Sara , Rouphael Carol , Mammadova Aytan , Witkin Linda , Khiyami Anamil , Amdur Richard L. , Sen Sabyasachi 
Published: May 2018

Abstract
Aims
Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition of saxagliptin, a DPP-IV inhibitor, to metformin, may reduce cardiovascular disease risk in addition to improving glycemic control in Type 2 diabetes patients.

Methods
In 12 week, double-blind, randomized placebo-controlled trial, 42 subjects already taking metformin 1–2 grams/day were randomized to placebo or saxagliptin 5 mg. Subjects aged 40–70 years with diabetes for < 10 years, with no known cardiovascular disease, BMI 25–39.9, HbA1C 6–9% were included. We evaluated EPCs number, function, surface markers and gene expression, in addition to arterial stiffness, blood biochemistries, resting energy expenditure, and body composition parameters. A mixed model regression to examine saxagliptin vs placebo, accounting for within-subject autocorrelation, was done with SAS (p < 0.05).

Results
Although there was no significant increase in CD34+ cell number, CD31+ cells percentage increased. Saxagliptin increased migration (in response to SDF1α) with a trend of higher colony formation count. MNCs cytometry showed higher percentage of CXCR4 double positivity for both CD34 and CD31 positive cells, indicating a functional improvement. Gene expression analysis showed an upregulation in CD34+ cells for antioxidant SOD1 (p < 0.05) and a downregulation in CD34− cells for IL-6 (p < 0.01). For arterial stiffness, both augmentation index and systolic blood pressure measures went down in saxagliptin subjects (p < 0.05).

Conclusion
Saxagliptin, in combination with metformin, can help improve endothelial dysfunction in early diabetes before macrovascular complications appear.
Trial registration Trial is registered under clinicaltrials.gov, NCT02024477
Modulation of F-actin dynamics by maternal Mid1ip1L controls germ plasm aggregation and furrow recruitment in the zebrafish embryo
Authors: Eno Celeste , Pelegri Francisco 
Published: May 2018

ABSTRACT
During the early embryonic cell cycles, zebrafish germ plasm ribonucleoparticles (RNPs) gradually multimerize and become recruited to the forming furrows. RNPs multimerization occurs prior to and during furrow initiation, as forming aggregates move outward through their association with the tips of growing interphase astral microtubules. Germ plasm RNPs are also associated with short cortical F-actin. We show that, in embryos mutant for the cytoskeletal regulator mid1ip1l, germ plasm RNPs fail to become recruited to the furrow, accumulating instead at the periphery of the blastodisc. RNP aggregates are associated with zones of mid1ip1l-dependent cyclical local cortical F-actin network enrichments, as well as contractions at both the cortex and the contractile ring. F-actin inhibition in wild-type embryos mimics the RNP peripheral accumulation defect of mid1ip1l mutants. Our studies suggest that a common mechanism underlies distinct steps of germ plasm RNP segregation. At the cortex, this process attenuates microtubule-dependent outward RNP movement to retain RNPs in the blastodisc cortex and allow their recruitment to the furrows. F-actin network contraction likely also facilitates higher-order germ plasm RNP multimerization.
Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes
Authors: Otero María Gabriela , Fernandez Bessone Ivan , Hallberg Alan Earle , Cromberg Lucas Eneas , De Rossi María Cecilia , Saez Trinidad M. , Levi Valeria , Almenar-Queralt Angels , Falzone Tomás Luis 
Published: May 2018

ABSTRACT
Alzheimer disease (AD) pathology includes the accumulation of poly-ubiquitylated (also known as poly-ubiquitinated) proteins and failures in proteasome-dependent degradation. Whereas the distribution of proteasomes and its role in synaptic function have been studied, whether proteasome activity regulates the axonal transport and metabolism of the amyloid precursor protein (APP), remains elusive. By using live imaging in primary hippocampal neurons, we showed that proteasome inhibition rapidly and severely impairs the axonal transport of APP. Fluorescence cross-correlation analyses and membrane internalization blockage experiments showed that plasma membrane APP does not contribute to transport defects. Moreover, by western blotting and double-color APP imaging, we demonstrated that proteasome inhibition precludes APP axonal transport by enhancing its endo-lysosomal delivery, where β-cleavage is induced. Taken together, we found that proteasomes control the distal transport of APP and can re-distribute Golgi-derived vesicles to the endo-lysosomal pathway. This crosstalk between proteasomes and lysosomes regulates the intracellular APP dynamics, and defects in proteasome activity can be considered a contributing factor that leads to abnormal APP metabolism in AD.
This article has an associated First Person interview with the first author of the paper.
ARF6 protects sister chromatid cohesion to ensure the formation of stable kinetochore-microtubule attachments
Authors: Bourmoum Mohamed , Charles Ricardo , Claing Audrey 
Published: May 2018

ABSTRACT
Sister chromatid cohesion, facilitated by the cohesin protein complex, is crucial for the establishment of stable bipolar attachments of chromosomes to the spindle microtubules and their faithful segregation. Here, we demonstrate that the GTPase ARF6 prevents the premature loss of sister chromatid cohesion. During mitosis, ARF6-depleted cells normally completed chromosome congression. However, at the metaphase plate, chromosomes failed to establish stable kinetochore-microtubule attachments because of the impaired cohesion at centromeres. As a result, the spindle assembly checkpoint (SAC) was active and cyclin B ubiquitylation and degradation were blocked. Chromosomes and/or chromatids in these cells scattered gradually from the metaphase plate to the two poles of the cell or remained blocked at the metaphase plate for hours. Our study demonstrates that the small GTP-binding protein ARF6 is essential for maintaining centromeric cohesion between sister chromatids, which is necessary for the establishment of stable k-fibres, SAC satisfaction and the onset of anaphase.
Reforma administrativa e direito adquirido
Authors: Modesto Paulo 
Published: May 2018

1. Do conceito de direito adquirido em vigor no Brasil. 2. Como funciona na prática a garantia que protege o direito adquirido? 3. Direitos adquiridos e reforma constitucional: a questão das cláusulas pétreas. 4. Direito adquirido e alteração abstrata do regime jurídico dos servidores públicos. 5. Sentido lógico e jurídico das emendas sobre direito adquirido na Reforma Administrativa.
As colectividades territoriais infraestaduais em Portugal
Authors: Gouveia Jorge Bacelar 
Published: May 2018

I - COLECTIVIDADES TERRITORIAIS INFRAESTADUAIS EM GERAL. - § 1º Conceito e espécies. 1 - Conceito. 2 - Espécies. - § 2º Entidades afins. 3 - Instituições públicas. 4 - Associações públicas. 5 - Distritos. 6 - Organizações de moradores.
Servidor - Estabilidade - Art. 19 ADCT
Authors: Pereira Miguel Frauzino 
Published: May 2018

- O destinatário do artigo 19 do ADCT da Carta Magna, no tocante ao requisito do "exercício na data da promulgação da Constituição há pelo menos cinco anos continuados ", é aquele que esteja vinculado a uma das pessoas jurídicas de direito público ali relacionadas na qualidade de servidor público, embora não admitido na forma regulada no art. 37 da Constituição, sem hiatos quanto a essa relação jurídica, ainda que a títulos diversos, desde que se sucedam sem solução de continuidade. Precedentes do STF.- Embora a títulos diferentes, mas sem solução de continuidade, ao ser promulgada a atual Constituição Federal, a ora recorrida era servidora pública - o art. 19 do ADCT não exclui dos servidores públicos os contratados pelo Estado com base na legislação trabalhista - e contava os cinco anos de exercício continuados,fazendo jus, assim, à estabilidade ali prevista, razão por que não poderia ser demitida "ad nutum ".Recurso extraordinário não conhecido.
Servidor público - URP de fevereiro de 1989 - Reajuste
Authors: Batista Wagner Natal 
Published: May 2018

- Reajuste de vencimento do mês de fevereiro de 1989, segundo a variação da URP (Unidade de Referência de Preços) (Índice de 26,05%) (Dec.-lei 2.335, de 12-06-1987).- Arts. 1º, 5º, e 6º da Lei n. 7.730, de 31-01-1989).- Medida Provisória nº 32, de 15.01.1989. Portaria ministerial nº 354, de 01.12.1988 (D.O. 02.12.1988).- Art. 1º, "caput", do Dec-lei n. 2.425, de 07-04-1988.- É firme a jurisprudência do Supremo Tribunal Federal, no Plenário e nas Turmas, no sentido de que não há direito adquirido ao reajuste de 26,05%, referente à URP de fevereiro de 1989.- E, quanto à URP de abril/maio de 1988, o Plenário e as Turmas têm decidido que os servidores fazem jus, tão-somente, ao valor correspondente a 7/30 (sete trinta avos) de 16,19% sobre os vencimentos de abril e maio de 1988, não cumulativamente, mas corrigidos monetariamente desde a data em que eram devidos até seu efetivo pagamento.- Observados os precedentes, o R.E. é conhecido e provido parcialmente, para denegação do reajuste de 26,05% e, quanto ao de 16,19%, para reduzi-lo a 7/30 (sete trinta avos) (desse percentual) sobre os vencimentos de abril e maio de 1988, na forma referida no item anterior.
Servidor estadual - Atraso de vencimento - Correção monetária
Authors: Pereira Miguel Frauzino 
Published: May 2018

- Recurso extraordinário. Pagamento de vencimentos. Constituição Estadual que estabelece data-limite para o pagamento de vencimentos, corrigindo-se monetariamente seus valores se pagos em atraso.- A jurisprudência desta Corte já se firmou (particularmente ao julgar a ADN 176) no sentido de que o estabelecimento, em Constituição Estadual, de data-limite para o pagamento dos servidores estaduais e a determinação de correção monetária, em caso de atraso, não ofendem o princípio da independência dos Poderes, pois não implicam a criação de cargos ou aumento de remuneração, nem ferem o poder de iniciativa exclusiva do Governador do Estado. Ademais, de há muito, e independentemente de lei que a imponha, este Tribunal se manifesta no sentido da incidência de correção monetária sobre os vencimentos pagos em atraso por entender tratar-se de dívida de caráter alimentar, assim, por haver, em última análise, a Constituição estadual reconhecido esse caráter a tais débitos, não há como pretender-se tenha ela invadido competência privativa da União Federal.- Recurso extraordinário não conhecido.
Cargo em comissão - Exoneração - Indenização
Authors: Silva Moacir Antônio Machado da 
Published: May 2018

- A nomeação para os cargos em comissão é feita sob a cláusula expressa de livre exoneração.- A disposição que prevê o pagamento pelos cofres públicos de indenização compensatória aos ocupantes de cargos em comissão, sem outro vínculo com o serviço público, por ocasião da exoneração ou dispensa, restringe a possibilidade de livre exoneração, tal como prevista no art. 37, II, combinado com o art. 25 da Constituição Federal.- Ação direta julgada procedente para declarar a inconstitucionalidade e a conseqüente ineficácia do art. 287 da Constituição do Estado de São Paulo, desde a sua promulgação.
Professor - Aposentadoria especial - Tempo de serviço
Authors: Fonteles Cláudio Lemos 
Published: May 2018

- O Plenário desta Corte declarou a inconstitucionalidade do art. 126, § 6º da Constituição do Estado de São Paulo. porque o art. 40 da Carta Federal é de observância obrigatória por todos os níveis do Poder Público.- Ao legislador é defeso fundir normas que regem a contagem do tempo de serviço para aposentadorias sob regimes diferentes. contando proporcionalmente o tempo de serviço exercido em funções diversas para fins de concessão de aposentadoria especial.- Recurso extraordinário conhecido e provido.
Concurso público - Prazo de validade - Novas vagas
Authors: Meira Jair Brandão de Souza 
Published: May 2018

- Administrativo. Concurso Público. Classificação.- Novas vagas. Criadas no prazo de validade do concurso, aos aprovados na primeira etapa assiste o direito de cursarem a segunda etapa, conforme a ordem de classificação.
Pensão por morte - Valor total - Limite
Authors: Santos Roberto Monteiro Gurgel 
Published: May 2018

- Na interpretação do art. 40, § 5º, da Constituição firmou-se o entendimento do STF, a partir do MI 211, RTJ 157/411, no sentido de que para conciliar-se com a parte inicial do preceito - segundo a qual "a pensão por morte corresponderá à totalidade dos vencimentos ou proventos do servidor falecido" - a melhor interpretação de sua parte final é a que vincula o "limite estabelecido em lei", que ali se prevê, não ao valor da pensão, mas ao da remuneração do morto, que lhe servirá de paradigma integral.
Prestação de serviços à Administração Pública após fim do prazo contratual
Authors: Aragão Alexandre Santos de 
Published: May 2018

I - Introdução. II- A natureza jurídica dos serviços prestados e a obrigação da Administração Pública em ressarci-los. III- O Quantum do ressarcimento. IV - O pagamento deverá ser feito mediante termo de ajuste de contas. V - Imprescindibilidade da apuração de eventuais responsabilidades funcionais. VI - Conclusão.
Gravação telefônica - Validade -Direito de Privacidade
Authors: Brindeiro Geraldo 
Published: May 2018

- Habeas Corpus. Prova. Licitude. Gravação de telefonema por interlecutor. É lícita a gravação de conversa telefônica feita por um dos interlocutores, ou com sua autorização, sem ciência do outro, quando há investida criminosa deste último. É inconsistente e fere o senso comum falar-se em violação do direito à privacidade quando interlocutor grava diálogo com seqüestradores, estelionatários ou qualquer tipo de chantagista.- Ordem indeferida.
Taxa - Ordem dos Advogados - Custas Judiciais
Authors: Brindeiro Geraldo 
Published: May 2018

- Ação direta de inconstitucionalidade. Lei n. 5.607, de 31 de maio de 1990, do Estado de Mato Grosso que atribui emfavorda OAB, Seção daquele Estado, parcela de custas processuais.- Exercendo a OAB, federal ou estadual, serviço público, por se tratar de pessoa jurídica de direito público (autarquia), e serviço esse que está ligado à prestação jurisdicional pela fiscalização da profissão de advogado que, segundo a parte inicial do art. 133 da Constituição, é indispensável à administração da justiça. não tem relevância. de plano, a fundamentação jurídica da argüição de inconstitucionalidade da lei em causa no sentido de que o serviço por ela prestado não se vincula à prestação jurisdicional, desvirtuando-se, assim, a finalidade das custas judiciais, como taxa que são.- Ausência, também, do "periculum in mora" ou da conveniência em suspender-se, liminarmente, a eficácia dessa Lei estadual.- Pedido de liminar indeferido.
Intervenção federal - Estado-membro - Decisão judicial
Authors: Mello Celso Antônio Bandeira de 
Published: May 2018

- O descumprimento, por parte de Estado-membro, de decisão judicialque lhe impôs condenação definitiva em sede trabalhista autoriza processode intervenção federal.- O credor deve, porém, dirigir ao Presidente do Tribunal do qualemanou a ordem judiciária o pedido de intervenção federal, não cabendofazê-lo diretamente ao Supremo Tribunal Federal. Supremo Tribunal Federal
Jenny Kee and Flamingo Park: Independent fashion retailers as creative practitioners
Authors: Tuite Alexandra 
Published: May 2018

Abstract
It is contended in this article that independent fashion retailers who display conscious and proactive cultural positioning can be considered as not only retail practitioners, but creative practitioners playing a cultural role in the fashion industry. Australian fashion retailer and designer Jenny Kee is used as a historic example. Kee opened her Flamingo Park retail store in Sydney in 1973 and later became one of Australia’s best-known fashion designers. Using primary sources from the Jenny Kee Archive at the Museum of Applied Arts and Sciences in Sydney in addition to Kee’s recollections in her autobiography, Kee’s retail work is viewed through the lens of Bourdieu’s field theory and her position in the field of fashion and role as a cultural intermediary is established. By framing her work in this way, the potential for a fashion retailer to mediate culture for fashion consumers using retailing as their creative practice is demonstrated.
A twist in the retail: The rise, fall and re-emergence of Budapest as a fashion city
Authors: Medvedev Katalin 
Published: May 2018

Abstract
Although the traditional focus in fashion studies on Western Europe and America has been widely critiqued, the examination of what influences and major institutions were critical in the diffusion of fashion in Eastern and Central Europe is still limited. To counter this drawback, this study charts the history of the development of fashion and fashion retailing in one Eastern Central European capital, Budapest, Hungary, from the early nineteenth century until the late 1960s. It brings to light that even though Budapest does not register as an important European fashion centre among western fashion scholars, the city had a steadily growing fashion production, consumption and retail scene in Eastern-Central Europe from the early nineteenth century until the Second World War, and again from the late 1960s onwards. It explores the ideological, political and economic reasons fashion and its supporting retail scene disappeared in Hungary after the communist takeover in 1948 and discusses what led to their gradual comeback following the 1956 Uprising against Soviet-style totalitarian dictatorship and the introduction of the New Economic Mechanism in 1968.
Just his style: The songs Hugh Martin created for MGM’s Meet Me in St. Louis
Authors: Christman Paul 
Published: May 2018

Abstract
In 1943, Hugh Martin and Ralph Blane were given the plum assignment of writing songs for Judy Garland to sing in the movie musical Meet Me in St. Louis. Although they had the advantage of having worked with her in New York City and Hollywood, for the young songwriters this was still a high-profile motion picture in which to be a part. Because the work’s title came from a 1904 song that the studio would use in addition to other period music, the challenge was to write new material that sounded as though it came from the turn of the century and that showcased Garland, America’s girl next door. All three songs that Martin created for Meet Me in St. Louis, ‘The Boy Next Door’, ‘The Trolley Song’ and ‘Have Yourself a Merry Little Christmas’, are emblematic of his writing style. An examination of Martin’s notebooks while at MGM reveals new insight into his process of lyric writing from initial drafts to final versions. In studying his compositions, one discovers how he was influenced by as well as adapted American popular song form. Martin’s skilled craftsmanship yielded the best-known songs of his career, and today they remain standards in the American Songbook.
Commitment in social choreography: Excavating the Martha Graham Dance Company
Authors: Tamler Cory 
Published: May 2018

Abstract
Where other, more autonomous art forms would have to share their political inventions in a show-and-tell that leads to the trap of didacticism, social choreography and other forms of social practice can leave room for invention without insisting on it. This approach, however, can give rise to a trap of its own: in the name of participation, artists fashion such an open, unregulated space for audience-participants that those who enter it fall back into roles they know. In this article, I look at a recent collaborative work of social choreography created by Austrian choreographer Michael Kliën with the Martha Graham Dance Company to argue that if social practice is really to intervene in the structure of social space, it must find the art in the way it responds to the pressure of the ordinary.
Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus
Authors: Rochmah Nur , Faizi Muhammad 
Published: May 2018

Background Children with type 1 diabetes mellitus (T1DM) are at risk of thyroid dysfunction. An association between diabetes duration and thyroid stimulating hormone level remains inconclusive.Objective To assess for a possible association between diabetes duration and thyroid stimulating hormone levels in children with T1DM.Methods We conducted a cross-sectional study from January to June 2017 in the Pediatric Endocrine Outpatient Clinic at Dr. Soetomo Hospital. Subjects were children with T1DM aged 7 to <18 years. Exclusion criteria were children with diabetic ketoacidosis, previously diagnosed thyroid problems, and hospitalization in the pediatric intensive care unit (PICU). Results From the 55 regular patients in our outpatient clinic, 34 patients were included in the study. Nineteen (54.3%) subjects were male, and the overall mean age was 11.3 years. Subjects’ mean duration of diabetes was 3 years and their mean thyroid stimulating hormone concentration was 3.76mIU/L. Pearson’s correlation test revealed no significant association between duration of diabetes and thyroid stimulating hormone level (rs=-0.068; P=0.703).Conclusion There is no significant association between duration of diabetes and thyroid stimulating hormone levels in children with T1DM.