bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐related differences in response to zinc pyrithione shampoo vs. non‐anti‐dandruff shampoo
Authors: Collins L. Z. , Baines F. L. , Matheson J. R. , Turner G. A. , Diao Y. , Li Y. , Pi Y. 
Published: November 2018

AbstractObjectiveSex‐related differences in skin properties may be expected to impact dandruff formation and treatment. A meta‐analysis approach was undertaken to investigate potential differences between males and females in response to zinc pyrithione (ZnPT) treatment vs. non‐anti‐dandruff (AD) shampoo. A separate pooled statistical analysis of ceramide and total protein loss endpoints was also undertaken to assess potential sex‐related differences in stratum corneum properties that might influence response to ZnPT vs. non‐AD shampoo in subjects with dandruff.MethodsThe meta‐analysis approach included data from 17 half‐head, double‐blind, randomized studies (N = 2088) undertaken in Asia to assess the effectiveness of 1% ZnPT shampoo and/or non‐AD shampoo in reducing dandruff severity, as assessed by Total Weighted Head Score Adherent Flake (TWHS‐AF) methodology. Treatment duration was 4 weeks, with TWHS‐AF measured at weekly intervals. Data from an additional three studies (N = 143) conducted in Asia were included in the pooled analysis of ceramide levels and protein loss from scalp skin of subjects with dandruff.ResultsResponse to 1% ZnPT vs. non‐AD shampoo was greater in males than in females at all time points; after 4 weeks, the between‐treatment difference in TWHS‐AF was −17.5 (95% confidence interval [CI] −19.5, −15.5) in males and −11.1 (−13.2, −8.9) in females. Sex‐related differences were observed between males and females in response to both 1% ZnPT and non‐AD shampoos. Males had a stronger response than females to treatment with 1% ZnPT shampoo, while dandruff decreased to a greater extent in females than in males when using non‐AD shampoo. Statistically significant sex‐related differences in ceramide levels and total protein loss were observed (both P < 0.01). Ceramide levels were 0.76 times lower (95% CI 0.60, 0.97) in males than in females, while total protein loss was 1.4 times greater (95% CI 1.1, 1.9) in males than in females.ConclusionMales show a greater response than females to 1% ZnPT shampoo, while females show a greater response than males to non‐AD shampoo. These findings may in part be explained by the sex‐related differences observed in stratum corneum properties, which may make males more prone to dandruff than females.
Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study
Authors: Ogrenim Gozde , Cesur Mine G. , Onal Tuna , Kara Murat , Sirin Fevziye B. , Yalcin Gizem D. , Inan Sevinc 
Published: November 2018

Structured AbstractObjectiveThe aim of this study was to investigate the effects of omega‐3 fatty acids on orthodontic tooth movement.Setting and Sample PopulationFor this study, 56 12‐week‐old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used.Material and MethodsRats were randomly divided into seven groups (n = 8 each): control group (without any treatment), tooth movement groups (three groups of animals with only tooth movement) and omega groups (three groups of animals with tooth movement and omega‐3 administration). Omega‐3 fatty acids were administered to the rats systemically during the tooth movement period. On the 3rd, 7th and 14th days after the orthodontic tooth movement, the rats were sacrificed and biochemical, histological, immunohistochemical andgene expression examinations were performed.ResultsOn the 14th experimental day, the amount of tooth movement in the omega groups was significantly lower than the tooth movement groups (P = 0.012). Biochemical experimentsshowed that the omega groups had significantly lower total oxidant levels and higher total antioxidant levels compared to the tooth movement group on the 14th experimental day (P = 0.001). The levels of RANKL, IL‐6 and IL‐1β in the omega groups were significantly lower than the tooth movement groups on all experimental days (P < 0.05).ConclusionSystemic administration of omega‐3 fatty acids showed antioxidant and antiinflammatory effects and decelerate the orthodontic tooth movement.
The Role of Sleep Quality and Fatigue on the Benefits of an Interdisciplinary Treatment for Adults With Chronic Pain
Authors: de la Vega Rocío , Racine Melanie , Castarlenas Elena , Solé Ester , Roy Rubén , Jensen Mark P. , Miró Jordi , Cane Douglas 
Published: November 2018

AbstractBackgroundInterdisciplinary chronic pain treatment is effective for reducing pain intensity and pain‐related disability, and for improving psychological function. However, the mechanisms that underlie these treatment‐related benefits are not yet well understood. Sleep problems and fatigue are modifiable factors often comorbid with chronic pain. The goal of this study was to evaluate the role that changes in sleep quality and fatigue might have on the benefits of an interdisciplinary chronic pain treatment.MethodsA total of 125 adults with chronic pain participated in a 4‐week interdisciplinary pain management program. Measures of depression, sleep disturbance, fatigue, pain intensity, and physical function were administered at pre‐ and post‐treatment. Three regression analyses were conducted to evaluate the contribution of pre‐ to post‐treatment improvements in fatigue and sleep disturbance to the pre‐ to post‐treatment improvements in pain intensity, disability, and depression, while controlling for demographic characteristics (age and sex) and pain intensity.ResultsChanges in fatigue and sleep disturbance made independent and significant contributions to the prediction of treatment‐related benefits in pain intensity; improvements in depressive symptoms were predicted by improvements in fatigue, and improvements in disability were only predicted by pre‐treatment and pre‐ to post‐treatment decreases in pain intensity (one of the control variables).ConclusionsIn addition to sleep, fatigue emerged as a key potential mechanism of multidisciplinary chronic pain treatment‐related improvements, suggesting that interventions including elements that effectively target sleep and fatigue may enhance the efficacy of interdisciplinary chronic pain programs. This possibility should be evaluated in future research.
Should more donation after cardiac death livers be used in pediatric transplantation?
Authors: Hwang Christine S. , Levea Swee‐Ling , Parekh Justin R. , Liang Yun , Desai Dev M. , MacConmara Malcolm 
Published: November 2018

AbstractIntroductionThere is a mismatch that exists in donor liver organ supply and demand. DCD livers represents a potential source to increase the number of liver grafts available for use in pediatric recipients; however, there has been hesitancy to use such organs. We evaluated patient and allograft outcomes in pediatric liver transplant recipients of DCD livers.MethodsThe UNOS database was queried to examine outcomes in all liver transplant recipients from 1993 to 2017. Patients were then divided according to adult and pediatric status, DBD or DCD allograft status, and era of transplant. Donor and recipient demographic data were examined, and patient and allograft survival were calculated. A P‐value of <0.05 was considered to be significant.ResultsA total of 57 pediatric recipients received a DCD liver allograft. DCD recipients were older than DBD recipients. There was no difference in the final PELD score between the groups. There were no differences in causes of allograft failure between the DCD and DBD groups. Importantly, the overall allograft survival in the DCD and DBD groups was similar, as was allograft survival based on era.ConclusionPediatric liver transplant recipients of DCD allografts have comparable patient and allograft survival when compared to DBD allograft recipients. Use of DCD allografts in the pediatric liver transplant population should be strongly considered to increase the donor organ pool.
Water‐Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation
Authors: de Gálvez María V. , Aguilera José , Sánchez‐Roldán Cristina , Herrera‐Acosta Enrique , Herrera‐Ceballos Enrique 
Published: November 2018

AbstractThe potential role of infrared radiation in photodermatoses has received very little attention, even though the main sources of radiation used for photobiological studies (UVA, UVB and visible light) include infrared radiation. The objective of the work was to assess whether infrared radiation is involved in the development of skin lesions in patients with different types of photodermatoses. Twenty patients with different photodermatoses were exposed to UVA, UVB and visible radiation using a high‐pressure mercury UVA lamp, a fluorescent broadband UVB lamp, a tungsten bulb and a slide projector for visible radiation. Part of the radiation emitted by these lamps was water‐filtered to block infrared radiation above 1300 nm. All 20 patients developed lesions when exposed to different light sources used for phototest. When exposed to same sources without infrared radiation, 17 patients (85%) did not develop any lesions and the other three (15%) developed less severe lesions than in the area exposed to unfiltered light. Our results show that infrared radiation was necessary for the development of skin lesions in 85% of the patients with photodermatoses in our study. We believe that infrared radiation studies should be included in standard photobiology protocols.
Effect of Toxic Metal Ions on Photosensitized Singlet Oxygen Generation for Photodegradation of Polyaromatic Hydrocarbon Derivatives and Inactivation of Escherichia coli
Authors: Herschmann Jacob R. , Ali Aqeeb , Harris Michele , McClinton Matthew , Zamadar Matibur 
Published: November 2018

AbstractHere, we report an experimental study of the effect of toxic metal ions on photosensitized singlet oxygen generation for photodegradation of PAH derivatives, Anthracene‐9,10‐dipropionic acid disodium salt (ADPA) and 1,5‐dihydroxynapthalene (DHN) and photoinactivation of Escherichia coli bacteria by using cationic meso‐tetra(N‐methyl‐4‐pyridyl)porphine tetrachloride (TMPyP) as a singlet oxygen photosensitizer. Three s‐block metals ions, such as Na+, K+ and Ca2+ and five toxic metals such as Cd2+, Cu2+, Hg2+, Zn2+ and Pb2+ were studied. The s‐block metal ions showed no change in the rate of photodegradation of ADPA or DHN by TMPyP, whereas a dramatic change in the photodegradation of ADPA and DHN was observed in the presence of toxic metals. The maximum photodegradation rate constants of ADPA and DHN were observed for Cd2+ ions [(3.91 ± 0.20) × 10−3 s−1 and (7.18 ± 0.35) × 10−4 s−1, respectively]. Strikingly, the photodegradation of ADPA and DHN was almost completely inhibited in the presence of Hg2+ ions and Cu2+ ions. A complete inhibition of growth of E. coli was observed upon visible light irradiation of E. coli solutions with TMPyP and toxic metal ions particularly, Cd2+, Hg2+, Zn2+ and Pb2+ ions, except for Cu2+ ions where a significantly slow inhibition of E. coli's growth was observed.
Prevalence of objectively measured sedentary behavior in early years: Systematic review and meta‐analysis
Authors: Pereira João Rafael , Cliff Dylan P. , Sousa‐Sá Eduarda , Zhang Zhiguang , Santos Rute 
Published: November 2018

BackgroundThe early years have been identified as a critical period during which sedentary habits may be established, as this behavior appears to track throughout life.ObjectiveThe purpose of this systematic review and meta‐analysis is to summarize the current literature on the prevalence of sedentary behavior in children aged 1‐5.99 years, reporting differences between boys and girls, weekdays and weekend days, childcare hours and nonchildcare hours, and between time spent indoors and outdoors while children attended childcare.MethodsFive databases were searched until 26.10.2017 and meta‐analyses were conducted to estimate prevalence and calculate mean differences in prevalence between groups.ResultsFifty studies representing 14 598 children (2‐5.99 years) were included. Children spent 51.4% of their waking time in sedentary behaviors. Boys spent less time being sedentary than girls (estimate difference = −1.4%; 95%CI = −2.0: −0.7; P < .001). No significant differences were found between weekdays/weekend days (estimate difference = −0.4; 95%CI = −2.0: 1.2; P = .61) nor between childcare hours/nonchildcare hours (estimate difference = %; 95%CI = −0.9: 6.6; P = .136). While attending childcare centers, children were more sedentary indoors than outdoors (estimate difference = 14.4%; 95%CI = 11.8: 16.9; P < .001).ConclusionsOur results suggest that young children spend a significant portion of their waking hours in sedentary behaviors. While at childcare, young children accumulated more sedentary behavior indoors than outdoors. Girls were more likely to be more sedentary than boys. No significant differences were found between weekdays and weekends, or between childcare and nonchildcare hours. There is a need for higher‐quality studies with strong designs, using age and device appropriate cut‐off points, to improve evidence‐base and to better establish prevalence of sedentary behavior in young children.
Freezing of dendritic cells with trehalose as an additive in the conventional freezing medium results in improved recovery after cryopreservation
Authors: Shinde Prajakta , Khan Nikhat , Melinkeri Sameer , Kale Vaijayanti , Limaye Lalita 
Published: November 2018

BACKGROUNDDendritic cell (DC) vaccination involves administration of multiple doses. Cryopreservation of tumor antigen–pulsed DCs can provide a ready to use vaccine source and eliminate the need of frequent withdrawal of the patient's blood for vaccine preparation. The aim of this study was to assess the effect of addition of trehalose in the freezing medium on the recovery of DCs after cryopreservation.STUDY DESIGN AND METHODSDCs were generated from mononuclear cells from apheresis samples of healthy donors. For long‐term storage of 6 months, cells were frozen with a rate‐controlled programmable freezer and stored in liquid nitrogen. For short‐term storage of 1 month, cells were frozen and stored at −80°C. DCs frozen with Iscove's Modified Dulbecco's Medium + 10% dimethyl sulfoxide + 20% fetal bovine serum served as the control group, while the test group was additionally supplemented with 50 μg/mL of trehalose. After revival of control and test DCs, they were assessed for viability, morphology, phenotype, and functions.RESULTSThe addition of trehalose to the conventional freezing medium helped to preserve the viability and functionality of DCs better than dimethyl sulfoxide alone in both long‐ and short‐term cryopreservation. Trehalose also protected the mitochondrial membrane potential and cytoskeleton integrity of DCs, which are necessary for their functionality. Mediators of the intrinsic apoptotic pathway like Caspase‐9 and Bim‐1 were found to be low in the test.CONCLUSIONSupplementation of conventional freezing medium with trehalose results in better quality of DCs revived after cryopreservation. This finding could help improve DC vaccine preparation for cancer immunotherapy.
Outcomes and risk factors of transfusion‐associated circulatory overload: a case control study
Authors: Daurat Aurélien , Grenie Jessie , Roger Claire , Daurat Gérald , Cuvillon Philippe , Muller Laurent , Lefrant Jean Yves 
Published: November 2018

BACKGROUNDTransfusion‐associated circulatory overload (TACO) is a growing concern in clinical practice.STUDY DESIGN AND METHODSA case control study was performed at the Nîmes University Hospital, France. TACO cases occurring after RBC transfusion reported from January 1, 2014, to May 31, 2017, were included as cases. Four controls by case were randomly selected among the other RBC recipients on the same day.RESULTSDuring the study period, 60 TACO diagnoses were reported for 37,029 transfused RBCs to a total of 8787 patients; 240 controls were included. The average rate of TACO was one case every 616 RBCs transfused. One in 146 transfused patients experienced TACO. TACO was associated with a higher 28‐day mortality (22% vs. 11%; p = 0.003), and a longer hospital stay compared with controls (23.5 ± 19.6 days vs. 15.9 ± 20.1 days; p < 0.001). Four risk factors were independently associated with TACO in multivariable analysis: chronic use of loop diuretics (odds ratio [OR], 6.5, 95% confidence interval [CI], 3.3–12.9), hemorrhagic shock (OR, 12; 95% CI, 2.9–50), body weight <46 kg (OR, 7.9; 95% CI, 2.3–26.8) and chronic hypertension (OR, 4.1; 95% CI, 2–8.5).CONCLUSIONTACO was frequent and associated with poor outcome. Four independent risk factors were identified: hemorrhagic shock, low body weight, chronic use of diuretics, and chronic hypertension.
Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice
Authors: Hendrikx Tim , Duan Yi , Wang Yanhan , Oh Jee-Hwan , Alexander Laura M , Huang Wendy , Stärkel Peter , Ho Samuel B , Gao Bei , Fiehn Oliver , Emond Patrick , Sokol Harry , van Pijkeren Jan-Peter , Schnabl Bernd 
Published: November 2018

ObjectiveAntimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine the mechanism that underlies REG3G suppression during experimental alcoholic liver disease.DesignInterleukin 22 (IL-22) regulates expression of REG3G. Therefore, we investigated the role of IL-22 in mice subjected to chronic-binge ethanol feeding (NIAAA model).ResultsIn a mouse model of alcoholic liver disease, we found that type 3 innate lymphoid cells produce lower levels of IL-22. Reduced IL-22 production was the result of ethanol-induced dysbiosis and lower intestinal levels of indole-3-acetic acid (IAA), a microbiota-derived ligand of the aryl hydrocarbon receptor (AHR), which regulates expression of IL-22. Importantly, faecal levels of IAA were also found to be lower in patients with alcoholic hepatitis compared with healthy controls. Supplementation to restore intestinal levels of IAA protected mice from ethanol-induced steatohepatitis by inducing intestinal expression of IL-22 and REG3G, which prevented translocation of bacteria to liver. We engineeredLactobacillus reuterito produce IL-22 (L. reuteri/IL-22) and fed them to mice along with the ethanol diet; these mice had reduced liver damage, inflammation and bacterial translocation to the liver compared with mice fed an isogenic control strain and upregulated expression of REG3G in intestine. However,L. reuteri/IL-22 did not reduce ethanol-induced liver disease inReg3g–/–mice.ConclusionEthanol-associated dysbiosis reduces levels of IAA and activation of the AHR to decrease expression of IL-22 in the intestine, leading to reduced expression of REG3G; this results in bacterial translocation to the liver and steatohepatitis. Bacteria engineered to produce IL-22 induce expression of REG3G to reduce ethanol-induced steatohepatitis.
Investigating sirukumab for rheumatoid arthritis: 2-year results from the phase III SIRROUND-D study
Authors: Thorne Carter , Takeuchi Tsutomu , Karpouzas George Athanasios , Sheng Shihong , Kurrasch Regina , Fei Kaiyin , Hsu Benjamin 
Published: November 2018

ObjectivesThe phase III, multicentre, randomised, double-blind, placebo-controlled, parallel-group SIRROUND-D study evaluated long-term efficacy and safety of the interleukin (IL)-6 inhibitor, sirukumab, in patients with active rheumatoid arthritis (RA) refractory to disease-modifying antirheumatic drugs (DMARDs).MethodsPatients were randomised 1:1:1 to sirukumab 100  mg every 2 weeks (q2w), 50  mg every 4 weeks or placebo q2w subcutaneously. Patients initially randomised to placebo were rerandomised at Weeks 18, 40 or 52 to one of the sirukumab groups until Week 104.ResultsOf 1670 randomised patients, 1402 were included in the full analysis set and 1269 in the radiographic analysis set at Week 104. American College of Rheumatology scores, Disease Activity Score based on C-reactive protein, Clinical Disease Activity Index and clinically meaningful improvements in patient-reported outcomes were sustained at Week 104 among patients initially randomised to sirukumab. Placebo patients subsequently rerandomised to sirukumab showed clinical improvements at Week 104 that were comparable to results among patients initially randomised to sirukumab. Radiographic progression from Week 52 to Week 104 was comparable between all groups whether initially randomised to sirukumab or subsequently rerandomised to sirukumab from placebo. No new safety signals were identified in the extended exposure period compared with the initial 52 weeks of treatment.ConclusionsSirukumab treatment resulted in sustained reductions in clinical signs and symptoms and minimal progression in radiographic damage over 2 years among patients with RA refractory to DMARDs. The safety profile of sirukumab was as expected for an anti-IL-6 agent, with no new signals reported.
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial
Authors: Nordberg Lena Bugge , Lillegraven Siri , Aga Anna-Birgitte , Sexton Joseph , Olsen Inge Christoffer , Lie Elisabeth , Berner Hammer Hilde , Uhlig Till , van der Heijde Desirée , Kvien Tore K , Haavardsholm Espen A 
Published: November 2018

ObjectivesRecent studies suggest that implementation of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time of diagnosis. Our aim was to compare the disease course in seronegative and seropositive patients classified according to the 2010 criteria.MethodsDMARD-naïve patients with RA fulfilling the 2010 criteria were included in the treat-to-target ARCTIC trial and followed for 24 months. We stratified patients as seropositive (rheumatoid factor (RF)+, anticitrullinated protein antibodies (ACPA)+ or both) or seronegative (RF– and ACPA–) and compared disease activity, radiographic progression, treatment response and remission rates across groups.Results230 patients were included with mean (SD) age 51.4 (13.7) years, and 61% were female. 34 patients (15%) were seronegative. At 24  months, disease activity measures, radiographic progression and remission rates were similar between groups, despite more inflammatory activity in seronegative patients at baseline. Treatment response was slower in seronegative compared with seropositive patients. The groups received similar treatment.ConclusionOur findings suggest that among patients with RA classified according to the 2010 ACR/EULAR criteria, seronegative patients respond well to modern treatment strategies. However, treatment response was somewhat slower in seronegative patients and radiographic progression was similar in seronegative and seropositive patients. Our results indicate that seronegative RA is not a mild form of the disease and requires intensive treat-to-target therapy similar to treatment of seropositive RA.