bluuebunny/crossref_metadata_2025_split huggingface dataset:
“My life has changed forever!”
Authors: Vásquez Camilla 
Published: June 2019

Abstract
New parodic genres have emerged across diverse forms of digital media. Sometimes these parodies take the form of mock “narratives of personal experience,” with authors drawing on a range of discursive resources to perform particular identities and in doing so, to create texts written from imagined perspectives. In this article, I focus on parodies of user-generated product reviews on Amazon. For over a decade, Amazon users have contributed thousands of parodies of reviews written about real products. This analysis focuses on a sample from a data set of 100 parodic Amazon reviews written about five different products (which have become the targets of a large number of parody reviews), and demonstrates how authors perform self-disclosure to construct fictional personae. I demonstrate how these discursively-constructed narrative identities are central to the ensuing and improbable narrative events represented in the parodic texts.
“We are going to our Portuguese homeland!”
Authors: Simões Marques Isabelle , Koven Michèle 
Published: June 2019

Abstract
This article combines the study of online narratives as social practices and the linguistic anthropological study of imagined communities, to examine a set of non-canonical narrative practices in a Facebook group for the Portuguese diaspora in France. Instead of reports of individual members’ past experiences, these narratives function as invitations to other group members to co-tell typical, shared experiences. Specifically, we investigate how group members share vacation trips to Portugal with each other in ways that produce a sense of collective and simultaneous experience. They accomplish this through deictically-based narrative strategies that shift the social, spatial, and temporal perspectives of narrating and narrated frames in ways that link the following: individual I’s with collective we’s, one-time events with timeless event types, and co-presence online with co-presence on vacation. Through these strategies, participants connect Facebook narrations of vacations to the larger social project of diasporic longing for and return to Portugal.
Gill diseases in marine salmon aquaculture with an emphasis on amoebic gill disease.
Authors: Rozas-Serri M. 
Published: June 2019

Abstract

Gill diseases are a growing health challenge in salmon farming worldwide, but many gaps remain in our knowledge. Gill diseases are generally complex and multifactorial disorders, often with presumable spatial and temporal distribution patterns, but are highly difficult to effectively prevent and control. The term complex gill disease (CGD) includes a wide range of clinical disease presentations on the gills of farmed salmon; usually, CGD presents from the end of summer to early winter. The pathogens involved include
Neoparamoeba perurans
,
Tenacibaculum maritimum
, Candidatus
Piscichlamydia salmonis
, Candidatus
Branchiomonas cysticola
,
Desmozoon lepeophtherii
(syn.
Paranucleospora theridion
) and viruses, such as the Atlantic salmon paramyxovirus (ASPV) and salmon gill poxvirus (SGPV). Amoebic gill disease (AGD) is perhaps the most significant disease in terms of gill health and economic impact. AGD results in high mortality, reduced production performance and impaired fish welfare. This review summarizes and analyses CGD research, outbreaks and treatment, with a focus on AGD, as well as on knowledge gaps and avenues for future research.
The Infected Diabetic Foot: Re-evaluating the Infectious Diseases Society of America Diabetic Foot Infection Classification
Authors: Lavery Lawrence A , Ryan Easton C , Ahn Junho , Crisologo Peter A , Oz Orhan K , La Fontaine Javier , Wukich Dane K 
Published: June 2019

Abstract

Background
We provide evidence to revise the Infectious Diseases Society of America (IDSA) diabetic foot infection classification by adding a separate tier for osteomyelitis and evaluating if moderate and severe infection criteria improve the classification’s ability to direct therapy and determine outcomes.

Methods
We retrospectively evaluated 294 patients with moderate and severe infections. Osteomyelitis was confirmed by bone culture or histopathology. Soft tissue infection (STI) was based on negative bone culture, magnetic resonance imaging, or single-photon emission computed tomography. We stratified STI and osteomyelitis using IDSA criteria for moderate and severe infections and compared outcomes and complications.

Results
Osteomyelitis patients had greater antibiotic duration (32.5 ± 46.8 vs 63.8 ± 55.1 days; P &lt; .01), surgery frequency (55.5% vs 99.4%; P &lt; .01), number of surgeries (2.1 ± 1.3 vs 3.3 ± 2.3; P &lt; .01), amputations (26.3% vs 83.4%; P &lt; .01), reinfection (38.0% vs 56.7%; P &lt; .01), and length of stay (14.5 ± 14.9 vs 22.6 ± 19.0 days; P &lt; .01). There were no differences in moderate and severe STI outcomes except for infection readmissions (46.2% vs 25.0%; P = .02), and acute kidney injury (31.2% vs 50.0%; P = .03). There were no differences in moderate and severe osteomyelitis except the number of surgeries (2.8 ± 2.1 vs 4.1 ± 2.5; P &lt; .01) and length of stay (18.6 ± 17.5 vs 28.2 ± 17.7; P &lt; .01).

Conclusions
The IDSA classification better reflects outcomes if risk categories are stratified by STI or osteomyelitis and moderate and severe infections are not categorized separately.
Myocardial performance index by tissue Doppler echocardiography predicts adverse events in patients with atrial fibrillation
Authors: Dons Maria , Olsen Flemming Javier , de Knegt Martina Chantal , Fritz-Hansen Thomas , Mogelvang Rasmus , Alhakak Alia Saed , Jespersen Thomas , Gislason Gunnar , Biering-Sørensen Tor 
Published: June 2019

Abstract

Aims
The prognostic value of myocardial performance index (MPI) has not yet been assessed in patients with atrial fibrillation (AF). The aim of this study was to evaluate the prognostic value of MPI by tissue Doppler imaging (TDI) M-mode in AF patients.

Methods and results
Echocardiograms from 210 patients with AF during examination were analysed offline. Patients with known heart failure (HF) were excluded. Time intervals were measured using an M-mode line through the mitral valve leaflets to provide a colour diagram of the mitral leaflet movement so all time intervals could be measured from one cardiac cycle. MPI was calculated as the sum of isovolumic relaxation time and isovolumic contraction time divided by the ejection time [(IVRT+IVCT)/ET]. During a median follow-up of 2.4 years, 84 patients (40%) reached the combined endpoint of major adverse cardiovascular events (MACE), being all-cause mortality, HF, myocardial infarction, or stroke. Increasing MPI was significantly associated with an increased risk of MACE, and the risk increased with 20% per 0.1 increase in MPI [hazard ratio (HR) 1.20, 95% confidence interval (CI) 1.10–1.32; P &lt; 0.001]. Increasing MPI was also significantly associated with a lower left ventricular ejection fraction (LVEF) (P &lt; 0.001). Nevertheless, MPI remained an independent predictor even after adjustment for age, sex, diabetes mellitus, left atrial volume, and LVEF (HR 1.12, 95% CI 1.01–1.25; P = 0.038).

Conclusion
Increasing MPI was significantly associated with increased risk of MACE and remained an independent predictor after multivariable adjustment. This demonstrates that the MPI obtained by TDI M-mode might be useful in assessing cardiac function in AF patients with ongoing arrhythmia during examination.
Exploring Wildfire-Prone Community Trust in Wildfire Management Agencies
Authors: Rasch Rebecca , McCaffrey Sarah 
Published: June 2019

AbstractThis research examines how trustworthy wildfire management agencies are perceived to be in five wildfire-prone communities. Trust was most often expressed in the context of agency abilities or competence (calculative trust), whereas distrust was framed in the context of intentions or the belief that the agency is not acting in the best interest of the community (relational trust). Five factors identified as closely tied to an individual’s trust in wildfire agencies are: communication from the agency; perceived relations among different management agencies, as well as between agencies and the public; experiences with wildfire agencies, particularly during wildfire events; experience with prescribed burns; and values or preferences for management actions. Managers hoping to build, maintain, or restore trust with communities may need to work on building a reputation of both competence and intention to act in the best interest of the community. Results indicate that level of trust in agencies varies considerably, both across and within communities, but that applied at the right scale, the wildfire community archetype framework, a method for rapidly identifying the level of adaptive capacity in wildfire-prone communities appears to be a relatively good indicator of the level of trust community members have in an agency’s abilities.
On the ancestry of woodrats
Authors: Martin Robert A , Zakrzewski Richard J 
Published: June 2019

Abstract
We evaluated the fossil record of extinct and extant woodrats, and generated a comprehensive phylogenetic hypothesis of woodrat origins and relationships based on these data. The galushamyinin cricetines are redefined and reclassified as a subtribe of the Neotomini, including Repomys, Miotomodon, Galushamys, Nelsonia, and a new extinct genus with two new species. The geographic distribution of Nelsonia, restricted to montane coniferous forests of western Mexico, suggests that this subtribe was mostly confined to western coniferous ecosystems or similar ecosystems at lower elevation during glacial advances. A second subtribe of the Neotomini includes a new archaic genus and species, Neotoma, Hodomys, and Xenomys. Lindsaymys, a possible neotominin from the late Clarendonian (late Miocene) of California, demonstrates an occlusal morphology consistent with ancestry for the Neotomini, but the presence of a fourth root on M1 is problematic and may preclude the known populations from filling that role. Molars identified as Neotoma sp. from the Hemphillian (latest Miocene or early Pliocene) Rancho el Ocote assemblage of Guanajuato, Mexico, may represent the earliest Xenomys. Extant Neotoma species with a bilobed m3 appear to have originated subsequent to about 2.0 Ma, whereas Hodomys alleni and Xenomys nelsoni likely originated earlier from one or more extinct ancestors with an S-shaped m3.
Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass
Authors: Yaksh Tony L. , Eddinger Kelly A. , Kokubu Shinichi , Wang Zhenping , DiNardo Anna , Ramachandran Roshni , Zhu Yuelian , He Yajun , Weren Fieke , Quang Daphne , Malkmus Shelle A. , Lansu Katherine , Kroeze Wesley K. , Eliceiri Brian , Steinauer Joanne J. , Schiller Peter W. , Gmeiner Peter , Page Linda M. , Hildebrand Keith R. 
Published: June 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
As the meningeally derived, fibroblast-rich, mass-produced by intrathecal morphine infusion is not produced by all opiates, but reduced by mast cell stabilizers, the authors hypothesized a role for meningeal mast cell/fibroblast activation. Using the guinea pig, the authors asked: (1) Are intrathecal morphine masses blocked by opiate antagonism?; (2) Do opioid agonists not producing mast cell degranulation or fibroblast activation produce masses?; and (3) Do masses covary with Mas-related G protein-coupled receptor signaling thought to mediate mast cell degranulation?

Methods
In adult male guinea pigs (N = 66), lumbar intrathecal catheters connected to osmotic minipumps (14 days; 0.5 µl/h) were placed to deliver saline or equianalgesic concentrations of morphine sulfate (33 nmol/h), 2’,6’-dimethyl tyrosine-(Tyr-D-Arg-Phe-Lys-NH2) (abbreviated as DMT-DALDA; 10 pmol/h; μ agonist) or PZM21 (27 nmol/h; biased μ agonist). A second pump delivered subcutaneous naltrexone (25 µg/h) in some animals. After 14 to 16 days, animals were anesthetized and perfusion-fixed. Drug effects on degranulation of human cultured mast cells, mouse embryonic fibroblast activation/migration/collagen formation, and Mas-related G protein-coupled receptor activation (PRESTO-Tango assays) were determined.

Results
Intrathecal infusion of morphine, DMT-DALDA or PZM21, but not saline, comparably increased thermal thresholds for 7 days. Spinal masses proximal to catheter tip, composed of fibroblast/collagen type I (median: interquartile range, 0 to 4 scale), were produced by morphine (2.3: 2.0 to 3.5) and morphine plus naltrexone (2.5: 1.4 to 3.1), but not vehicle (1.2: 1.1 to 1.5), DMT-DALDA (1.0: 0.6 to 1.3), or PZM21 (0.5: 0.4 to 0.8). Morphine in a naloxone-insensitive fashion, but not PZM21 or DMT-DALDA, resulted in mast cell degranulation and fibroblast proliferation/collagen formation. Morphine-induced fibroblast proliferation, as mast cell degranulation, is blocked by cromolyn. Mas-related G protein-coupled receptor activation was produced by morphine and TAN67 (∂-opioid agonist), but not by PZM21, TRV130 (mu biased ligand), or DMT-DALDA.

Conclusions
Opiates that activate Mas-related G protein-coupled receptor will degranulate mast cells, activate fibroblasts, and result in intrathecal mass formation. Results suggest a mechanistically rational path forward to safer intrathecal opioid therapeutics.
Responsiveness of EQ-5D Youth version 5-level (EQ-5D-5L-Y) and 3-level (EQ-5D-3L-Y) in Patients With Idiopathic Scoliosis
Authors: Wong Carlos King Ho , Cheung Prudence Wing Hang , Luo Nan , Lin Jiaer , Cheung Jason Pui Yin 
Published: June 2019

Study Design.
Prospective cohort study

Objective.
The aim of this study was to evaluate the responsiveness of EQ-5D Youth version (EQ-5D-Y) 5-level and 3-level in patients with idiopathic scoliosis

Summary of Background Data.
A new version of EQ-5D-Y increasing the number of response levels from 3 (3LY) to 5 (5LY) has been recently introduced. Although the validity and reliability of 5LY and 3LY for use in idiopathic scoliosis patients are compared, responsiveness of two questionnaires among children and adolescents is unknown.

Methods.
A total of 129 children or adolescents attending the spine clinics of a tertiary hospital in Hong Kong, China, completed 3LY and 5LY. At 3-month follow-up, 110 (85.2%) patients completed two EQ-5D-Y questionnaires, and the single-item Global Rating on Change Scale determining “worsened,”, “unchanged,”, or “improved” global health. Among those indicating “unchanged” in global health from baseline to follow-up, agreement in responses to each 3LY and 5LY item was examined. Mean changes in EQ-5D-Y scores during the past 3 months in patients with “worsened,” “unchanged,” and “improved” health were calculated.

Results.
Most patients (82.7%) reported no change in global health, whereas about 12.7% and 4.5% of them felt better and worse, respectively, compared to baseline. Among those reporting “unchanged health,” the “Looking after myself” item exhibited the largest proportion of agreement in responses (5LY: 96.36%; 3LY: 95.50%), followed by “Mobility” (5LY 90.91%; 3LY 90.99%), “Usual activities” (5LY 83.64%; 3LY 87.39%), “Pain/discomfort”(5LY 68.18%; 3LY 76.58%), and “Feeling worried/sad/unhappy” (5LY 66.36%; 3LY 72.07%). In the “improved” or “worsened” group, the 3-month follow-up 5LY and 3LY scores were higher or lower compared with baseline, respectively.

Conclusion.
The 5LY is demonstrated as responsive as the 3LY for patients with idiopathic scoliosis.

Level of Evidence: 2
The Role of Cross-Links in Posterior Spinal Fusion for Cerebral Palsy–Related Scoliosis
Authors: Usmani M. Farooq , Shah Suken A. , Yaszay Burt , Samdani Amer F. , Cahill Patrick J. , Newton Peter O. , Marks Michelle C. , Sponseller Paul D. 
Published: June 2019

Study Design.
Retrospective review of a multicenter, prospective database.

Objective.
Our aim was to compare complication rates and maintenance of radiographic correction at 2 years after posterior spinal fusion (PSF) with or without cross-links in patients with cerebral palsy (CP)–related scoliosis.

Summary of Background Data.
Cross-links are frequently used in PSF to correct scoliosis in patients with CP because they are thought to increase the stiffness and torsional rigidity of the construct.

Methods.
We reviewed the records of patients with CP who underwent primary PSF with or without cross-links between August 2008 and April 2015. Inclusion criteria were minimum follow-up of 2 years, availability of complications data (implant failure, surgical site infection, revision), and pre- and postoperative measurements of the major curve (measured using the Cobb method). The 256 patients included in this analysis had a mean age of 14.1 ± 2.7 years. Ninety-four patients had cross-links (57% using one cross-link; 43% using two cross-links) and 162 patients did not have cross-links. P < 0.05 was considered statistically significant.

Results.
The two groups did not differ significantly with regard to sex, age at surgery, preoperative menarche status, Gross Motor Function Classification System level, major curve magnitude, pelvic obliquity, kyphosis, and lordosis angles. There were no significant differences between groups in the correction achieved or the maintenance of correction at 2 years for the major curve, pelvic obliquity, kyphosis, or lordosis (all P > 0.05). Complication rates were similar between the cross-link group (16%, N = 15) and the non–cross-link group (14%, N = 22).

Conclusion.
At 2 years after PSF to treat CP-related scoliosis, patients had no significant differences in the degree of correction achieved, the maintenance of correction, or the rate of complications between those whose fusion constructs used cross-links and those whose constructs did not.

Level of Evidence: 3
Drug causes of ischaemic stroke
Authors: Burrage Daniel R. 
Published: June 2019

Summary
There is a wide range of drugs with the potential to cause ischaemic stroke. Whilst the absolute risk of stroke with commonly used drugs is low, a patient's background risk of stroke can increase their chance of stroke in combination with a particular drug. Careful decision-making is required when initiating and continuing treatment to ensure the risk-benefit profile of a drug is weighed appropriately on an individual patient basis.
Observation of Ground-level Enhancement Across Canada’s Fixed Point Surveillance Network During the 20 January 2005 Solar Event
Authors: Liu Chuanlei , Ungar Kurt , Zhang Weihua , Korpach Ed , Benotto Mike , Pellerin Eric 
Published: June 2019

Abstract
This paper presents the count rate enhancement observed across Canada’s Fixed Point Surveillance network during the solar event on 20 January 2005 and explores the feasibility and value of applying the Fixed Point Surveillance network’s long-term and continuous observations for space weather monitoring. The count rate, recorded in the high-energy channel of RS250 sodium iodide detectors, reflects the detector’s response to muonic and electromagnetic components of the cosmic ray shower. During the event peak time, simultaneous count rate increases have been observed across many Fixed Point Surveillance network stations at enhancements varying from 10% to 18%, 12- to 15-fold less than relative increases in neutron detector observations.
Sham surgeries for central and peripheral neural injuries persistently enhance pain-avoidance behavior as revealed by an operant conflict test
Authors: Odem Max A. , Lacagnina Michael J. , Katzen Stephen L. , Li Jiahe , Spence Emily A. , Grace Peter M. , Walters Edgar T. 
Published: June 2019

AbstractStudies using rodent models of neuropathic pain use sham surgery control procedures that cause deep tissue damage. Sham surgeries would thus be expected to induce potentially long-lasting postsurgical pain, but little evidence for such pain has been reported. Operant tests of voluntary behavior can reveal negative motivational and cognitive aspects of pain that may provide sensitive tools for detecting pain-related alterations. In a previously described operant mechanical conflict test involving lengthy familiarization and training, rodents freely choose to either escape from a brightly lit chamber by crossing sharp probes or refuse to cross. Here, we describe a brief (2-day) mechanical conflict protocol that exploits rats' innate exploratory response to a novel environment to detect persistently enhanced pain-avoidance behavior after sham surgeries for 2 neural injury models: thoracic spinal cord injury and chronic constriction injury of the sciatic nerve. Pitting the combined motivations to avoid the bright light and to explore the novel device against pain from crossing noxious probes disclosed a conflicting, hyperalgesia-related reluctance to repeatedly cross the probes after injury. Rats receiving standard sham surgeries demonstrated enhanced pain-like avoidance behavior compared with naive controls, and this behavior was similar to that of corresponding chronic constriction injury or spinal cord injury rats weeks or months after injury. In the case of sham surgery for spinal cord injury, video analysis of voluntary exploratory behavior directed at the probes revealed enhanced forepaw withdrawal responses. These findings have important implications for preclinical investigations into behavioral alterations and physiological mechanisms associated with postsurgical and neuropathic pain.
Hepatocellular carcinoma recurrence after liver transplantation in a Brazilian multicenter study: clinical profile and prognostic factors of survival
Authors: Chagas Aline L. , Felga Guilherme E.G. , Diniz Marcio A. , Silva Renato F. , Mattos Angelo A. , Silva Rita C.M.A. , Boin Ilka F.S.F. , Garcia José H.P. , Lima Agnaldo S. , Coelho Julio C.U. , Bittencourt Paulo L. , Alves Venâncio A.F. , D’Albuquerque Luiz A.C. , Carrilho Flair J. 
Published: June 2019

Background
Liver transplantation (LT) is the treatment of choice for patients with unresectable early hepatocellular carcinoma (HCC). Post-LT HCC recurrence rates range from 8 to 20% and still impact on overall survival (OS). The aim of our study was to evaluate the impact of HCC recurrence on post-LT survival and analyze prognostic factors among those patients with recurrence.

Patients and methods
We carried out a national, multicenter, retrospective cohort study in Brazil. Medical records of 1119 LT recipients with HCC were collected. Data from patients with post-LT HCC recurrence were analyzed and correlated with post-relapse survival.

Results
OS of the 1119 patients included in the study was 63% over 5 years. Post-LT HCC recurrence occurred in 86 (8%) patients. The mean time to recurrence was 12 months. Sites of recurrence were extrahepatic in 55%, hepatic in 27%, and both hepatic and extrahepatic in 18%. Recurrence treatment was performed in 50 (64%) cases, mostly with sorafenib. Post-relapse survival rates were 34% at 1 year and 13% at 5 years. Univariable analysis identified α-fetoprotein more than 1000 ng/ml at relapse, recurrence treatment, extrahepatic location, and time to recurrence more than 2 years as prognostic factors. In multivariable analysis, recurrence treatment, extrahepatic location, and time to recurrence more than 2 years were independent predictors of better survival.

Conclusion
In a large Brazilian cohort of LT recipients with HCC, post-LT HCC recurrence occurred in 8% and impacted significantly on the OS. Patients with early recurrence presented a worse prognosis. However, treatment of recurrence improved outcomes, highlighting the importance of early diagnosis.