bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Non-coding RNAome of RPE cells under oxidative stress suggests unknown regulative aspects of Retinitis pigmentosa etiopathogenesis
Authors: Donato Luigi , Scimone Concetta , Rinaldi Carmela , D’Angelo Rosalia , Sidoti Antonina 
Published: November 2018

AbstractThe discovery of thousands of non-coding RNAs has revolutionized molecular biology, being implicated in several biological processes and diseases. To clarify oxidative stress role on Retinitis pigmentosa, a very heterogeneous and inherited ocular disorder group characterized by progressive retinal degeneration, we realized a comparative transcriptome analysis of human retinal pigment epithelium cells, comparing two groups, one treated with oxLDL and one untreated, in four time points (1 h, 2 h, 4 h, 6 h). Data analysis foresaw a complex pipeline, starting from CLC Genomics Workbench, STAR and TopHat2/TopHat-Fusion alignment comparisons, followed by transcriptomes assembly and expression quantification. We then filtered out non-coding RNAs and continued the computational analysis roadmap with specific tools and databases for long non-coding RNAs (FEELnc), circular RNAs (CIRCexplorer, UROBORUS, CIRI, KNIFE, CircInteractome) and piwi-interacting RNAs (piRNABank, piRNA Cluster, piRBase, PILFER). Finally, all detected non-coding RNAs underwent pathway analysis by Cytoscape software. Eight-hundred and fifty-four non-coding RNAs, between long non-coding RNAs and PIWI-interacting, were differentially expressed throughout all considered time points, in treated and untreated samples. These non-coding RNAs target host genes involved in several biochemical pathways are related to compromised response to oxidative stress, visual functions, synaptic impairment of retinal neurotransmission, impairment of the interphotoreceptor matrix and blood – retina barrier, all leading to retinal cell death. These data suggest that non-coding RNAs could play a relevant role in Retinitis pigmentosa etiopathogenesis.
Monitoring Mechanical, Electronic, and Catalytic Trends in a Titanium Metal Organic Framework Under the Influence of Guest-Molecule Encapsulation Using Density Functional Theory
Authors: Dong Hieu C. , Nguyen Ha L. , Le Hung M. , Thoai Nam , Kawazoe Yoshiyuki , Nguyen-Manh Duc 
Published: November 2018

AbstractIn this study, we conduct a density functional theory investigation to study the mechanical stability of a titanium-based metal organic framework (MOF-901), which was hypothetically assumed to possess 2D characteristics. It is systematically found that the encapsulation of methanol enhances the mechanical stability of MOF-901 as the elastic tensors Cij of MOF-901∙nMeOH are higher than the corresponding Cij quantities reported for solvent-free MOF-901. Moreover, the 2D characteristics of MOF-901 is confirmed by verifying the negative values of C33. At the same time, the band gap of MOF-901 is observed to be solvent-dependent. In its pure form, MOF-901 possesses a direct gap (Eg) of 2.07 eV, with the valence and conduction bands mainly constituted by electrons of 4-aminobenzoate linkers. Introducing methanol into MOF-901 causes distortion to the 4-aminobenzoate geometry, thereby induces electronic degeneracy to the conduction bands. Consequently, Eg is narrowed to 1.84 eV with 5.7 wt% MeOH or 1.63 eV with 11.4 wt% MeOH. Hence, it is possible to tailor the band gap of MOF-901 by controlling methanol guest, which only acquires van der Waals interaction to the framework. In addition, our theoretical prediction shows a Ti(IV) site can undergo electronic hopping to become Ti(III) under the effect of visible light (~440–443 nm). Then, Ti(III) is capable of breaking the C-Br bond in ethyl α-bromophenylacetate spontaneously, which in turn activates the polymerization of methyl methacrylate with an energy barrier of 0.30 eV.
Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation
Authors: Arjunan Pachiappan , Meghil Mohamed M. , Pi Wenhu , Xu Jinxian , Lang Liwei , El-Awady Ahmed , Sullivan William , Rajendran Mythilypriya , Rabelo Mariana Sousa , Wang Tong , Tawfik Omnia K. , Kunde-Ramamoorthy Govindarajan , Singh Nagendra , Muthusamy Thangaraju , Susin Cristiano , Teng Yong , Arce Roger M. , Cutler Christopher W. 
Published: November 2018

AbstractChronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the ‘keystone’ pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + Tregs through an anti-apoptotic pathway. This pathway, involving pAKT1, pFOXO1, FOXP3, IDO1 and BIM, is activated in humans with CP and in mice orally infected with Mfa1 expressing P. gingivalis strains. Mechanistically, activation of this pathway, demonstrating FOXP3 as a direct FOXO1-target gene, was demonstrated by ChIP-assay in human CP gingiva. Expression of oncogenic but not tumor suppressor markers is consistent with tumor cell proliferation demonstrated in OSCC-P. gingivalis cocultures. Importantly, FimA + P. gingivalis strain MFI invades OSCCs, inducing inflammatory/angiogenic/oncogenic proteins stimulating OSCCs proliferation through CXCR4. Inhibition of CXCR4 abolished Pg-MFI-induced OSCCs proliferation and reduced expression of oncogenic proteins SDF-1/CXCR4, plus pAKT1-pFOXO1. Conclusively, P. gingivalis, through Mfa1 and FimA fimbriae, promotes immunosuppression and oncogenic cell proliferation, respectively, through a two-hit receptor-ligand process involving DC-SIGN+hi/CXCR4+hi, activating a pAKT+hipFOXO1+hiBIM−lowFOXP3+hi and IDO+hi- driven pathway, likely to impact the prognosis of oral cancers in patients with periodontitis.
Optimal positioning of storage systems in microgrids based on complex networks centrality measures
Authors: Korjani Saman , Facchini Angelo , Mureddu Mario , Caldarelli Guido , Damiano Alfonso 
Published: November 2018

AbstractWe propose a criterion based on complex networks centrality metrics to identify the optimal position of Energy Storage Systems in power networks. To this aim we study the relation between centrality metrics and voltage fluctuations in power grids in presence of high penetration of renewable energy sources and storage systems. For testing purposes we consider two prototypical IEEE networks and we compute the correlation between node centrality (namely Eigenvector, Closeness, Pagerank, Betweenness) and voltage fluctuations in presence of intermittent renewable energy generators and intermittent loads measured from domestic users. We show that the topological characteristics of the power networks are able to identify the optimal positioning of active and reactive power compensators (such as energy storage systems) used to reduce voltage fluctuations according to the common quality of service standards. Results show that, among the different metrics, eigenvector centrality shows a statistically significant exponential correlation with the reduction of voltage fluctuations. This finding confirms the technical know-how for which storage systems are heuristically positioned far from supply reactive nodes. This also represents an advantage both in terms of computational time, and in terms of planning of wide resilient networks, where a careful positioning of storage systems is needed, especially in a scenario of interconnected microgrids where intermittent distributed energy sources (such as wind or solar) are fully deployed.
The increasing variability of tropical cyclone lifetime maximum intensity
Authors: Song Jinjie , Klotzbach Philip J. , Tang Jianping , Wang Yuan 
Published: November 2018

AbstractThis study investigates long-term changes in the variability of TC intensity of global tropical cyclones, a topic which has been relatively infrequently studied to date. Our study finds that the variability of global TC lifetime maximum intensity (LMI), as measured by the LMI standard deviation, increases during 1981–2016. The increasing trend in LMI variability is statistically significant for both the Northern and Southern Hemispheres, with three individual TC basins: the western North Pacific, the South Indian and the South Pacific also having statistically significant increases. This increasing trend primarily results from distinct changes in the relative percentages of TCs with different intensities. When comparing two periods: 1981–1998 and 1999–2016, the proportions of weak and strong TCs increase, whereas moderate TCs occur relatively less frequently. This bimodal pattern of observed LMI distribution change is further linked to opposite trends in the average intensities of TCs that undergo rapid intensification (RI) during their lifetime (RI TCs) and those that do not (non-RI TCs). The LMI distributions of RI and non-RI TCs migrate to higher and lower intensities, respectively. Our results demonstrate from an observational perspective that strong TCs have strengthened while weak TCs have weakened as the global climate has warmed since 1981.
Structural and compositional study of precipitates in under-aged Cu-added Al-Mg-Si alloy
Authors: Maeda Takuya , Kaneko Kenji , Namba Takuya , Koshino Yuki , Sato Yukio , Teranishi Ryo , Aruga Yasuhiro 
Published: November 2018

AbstractAtomic scale characterization of fine precipitates in an under-aged Cu added Al-Mg-Si alloy was carried out by combination of atomically-resolved annular dark-field scanning transmission electron microscopy and energy dispersive X-ray spectroscopy. Two types of precipitates were observed in the alloy. In the case of ordered β” precipitates, β” was proposed as Mg5-xAl2+xSi4 (x ≈ 1) with solute Cu atoms replacing Al site of β” precipitate. In the case of disordered precipitates, the precipitates were found to consist of β” sub-unit cells, three-fold symmetric structure without Cu atoms, Cu containing structures termed as “Cu sub-unit cluster”, and Q’ sub-unit cells. Among these structures, the morphologies of three-fold symmetric structure without Cu atoms, Cu sub-unit cluster, and Q’ sub-unit cell were almost the same, so that these structures should be the clusters of Q’ phase. Since the areal density, length and diameter of precipitates were almost equal between Cu free Al-Mg-Si alloy and Cu added Al-Mg-Si alloy, the increase of hardness by Cu addition should be due to the precipitation of Cu related precipitates, such as Cu sub-unit clusters and Q’ sub-unit cells.
Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
Authors: Nabofa Williams E. E. , Alashe Oluwadamilola O. , Oyeyemi Oyetunde T. , Attah Alfred F. , Oyagbemi Ademola A. , Omobowale Temidayo O. , Adedapo Adeolu A. , Alada Akinola R. A. 
Published: November 2018

AbstractMyocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg), groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7thday in groups B-E animals. On the 9thday electrocardiogram (ECG) was recorded, blood samples and tissue biopsies were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1) which were significantly reduced in guinea pig’s pretreated with metoprolol or CurNisNp (P < 0.05). The LC50of CurNisNp was 3258.2 μg/mL. This study demonstrated that the formulated curcumin-nisin based nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic.
Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance
Authors: Pennings Jeroen L. A. , Mariman Rob , Hodemaekers Hennie M. , Reemers Sylvia S. N. , Janssen Riny , Guichelaar Teun 
Published: November 2018

AbstractAging poses an increased risk of severe infection by respiratory syncytial virus (RSV). The many different biological pathways comprising the response to infection in lungs that are influenced by aging are complex and remain to be defined more thoroughly. Towards finding new directions in research on aging, we aimed to define biological pathways in the acute response to RSV that are affected in the lungs by aging. We therefore profiled the full transcriptome of lung tissue of mice prior to and during RSV infection both at young and old age. In the absence of RSV, we found aging to downregulate genes that are involved in constitution of the extracellular matrix. Moreover, uninfected old mice showed elevated expression of pathways that resemble injury, metabolic aberrations, and disorders mediated by functions of the immune system that were induced at young age only by an exogenous trigger like RSV. Furthermore, infection by RSV mounted stronger activation of anti-viral type-I interferon pathways at old age. Despite such exaggerated anti-viral responses, old mice showed reduced control of virus. Altogether, our findings emphasize important roles in aging-related susceptibility to respiratory disease for extracellular matrix dysfunctions and dysregulated immune activation in lungs.
Bandwidth‐tunable filtering balun based on compact 3D configuration
Authors: Yao Lidan , Wu Yongle , Li Mingxing , Wang Weimin , Liu Yuanan 
Published: November 2018

For the first time, a novel bandwidth‐tunable filtering balun based on compact 3D configuration is presented. The overall design is basically composed of a two‐layer horizontal feeding plane, a three‐layer vertically mounted plane, and the transmission‐line circuits disposed on both. Implementing the ring resonator in vertical double‐sided parallel‐strip line, the complete horizontal ground and frequency‐independent phase difference are subtly combined. Connecting the shunt varactor diodes with the inserted vertical ground, the desirable filtering property and flexible bandwidth tunability are splendidly fulfilled. A prototype balun centred at 1.53 GHz is fabricated. The measured operating bandwidth is dynamically tuned from 0.87 to 1.23 GHz with a return loss <−10 dB, forcefully validating the design concept.
Short-term variability and mass loss in Be stars
Authors: Baade D. , Pigulski A. , Rivinius Th. , Wang L. , Martayan Ch. , Handler G. , Panoglou D. , Carciofi A. C. , Kuschnig R. , Mehner A. , Moffat A. F. J. , Pablo H. , Rucinski S. M. , Wade G. A. , Weiss W. W. , Zwintz K. 
Published: November 2018

Context. In early-type Be stars, groups of nonradial pulsation (NRP) modes with numerically related frequencies may be instrumental for the release of excess angular momentum through mass-ejection events. Difference and sum/harmonic frequencies often form additional groups.Aims. The purpose of this study is to find out whether a similar frequency pattern occurs in the cooler third-magnitude B7-8 IIIe shell starνPup.Methods. Time-series analyses were performed of space photometry with BRITE-Constellation (2015, 2016/17, and 2017/18), SMEI (2003–2011), and HIPPARCOS(1989–1993). Two IUE SWP and 27 optical echelle spectra spanning 20 years were retrieved from various archives.Results. The optical spectra exhibit no anomalies or well-defined variabilities. A magnetic field was not detected. All three photometry satellites recorded variability near 0.656 c/d which is resolved into three features separated by ∼0.0021 c/d. Their first harmonics and two combination frequencies form a second group, whose features are similarly spaced by 0.0021 c/d. The frequency spacing is very nearly but not exactly equidistant. Variability near 0.0021 c/d was not detected. The long-term frequency stability could be used to derive meaningful constraints on the properties of a putative companion star. The IUE spectra do not reveal the presence of a hot subluminous secondary.Conclusions.νPup is another Be star exhibiting an NRP variability pattern with long-term constancy and underlining the importance of combination frequencies and frequency groups. This star is a good target for efforts to identify an effectively single Be star.
Professioneller Informationsaustausch
Authors: Beese Florian 
Published: November 2018

ZusammenfassungAuf Intensivstationen ist die Weitergabe von Informationen besonders wichtig. Ob
Dienstwechsel oder Verlegung von Patienten – alle betreuenden Pflegenden sind
auf eine angemessene Übergabe und die Kenntnis sicherheitsrelevanter Aspekte im
Umgang mit den Patienten angewiesen. Dennoch sind übermittelte Informationen oft
falsch oder unzureichend. Wie es dazu kommt und was man dagegen tun kann,
beleuchtet der folgende Beitrag und fokussiert dabei auf das spezielle Setting
der Respiratory Care Unit.
Sinnvoll für den Patienten, hilfreich fürs
Personal
Authors: Bräunig Jochen , Gottschalk Antje 
Published: November 2018

ZusammenfassungFrühmobilisation wirkt sich erwiesenermaßen auf Intensivpatienten positiv aus.
Dabei ist auch die richtige Positionierung des Patienten wichtig, die sich mit
geeignetem Lagerungsmaterial erreichen lässt. Herkömmliches Material ist dabei
oft ungeeignet, wird falsch oder gar nicht benutzt und kann zu gefährlichen
Situationen für den Patienten führen. An der Uniklinik Münster haben die beiden
Autoren daher anhand eines eigens entwickelten und an die Betten der
Intensivstation angepassten Lagerungswürfel-Sets versucht herauszufinden, wie
sich dieses Hilfsmittel bei den Pflegekräften im täglichen Umgang bewährt.
Levothyroxine Therapy Achieves Physiological FT3/FT4 Ratios at Higher than Normal TSH Levels: A Novel Justification for T3 Supplementation?
Authors: Strich David , Chay Cherut , Karavani Gilad , Edri Shalom , Gillis David 
Published: November 2018

AbstractIn euthyroidism, as thyroid Stimulating hormone (TSH) levels increase, the free triiodothyronine (FT3) to free thyroxine (FT4) ratio increases. The aim of this study was to assess if beyond the euthyroid range of TSH levels FT3/FT4 ratio continues to increase and if levothyroxine treatment reduces this ratio, possibly through TSH suppression. This cross sectional retrospective study included a total of 77 832 patients [age 22.76±15.17 years (4 days to 112 years)] evaluated and treated in community clinics between January 2009 and September 2013. Blood samples drawn in community clinics for which TSH, FT4, FT3, age, and gender were available were included. Tests with TSH below 0.5 IU/l were excluded as were samples taken during pregnancy. The FT3/FT4 ratio continued to increase significantly even with TSH above 50 mIU/l (p for trend<0.001) with an increase of more than 50% over the entire TSH range. With increasing age and female gender, the phenomenon was less prominent (p<0.001). Levothyroxine treated patients had significantly lower FT3/FT4 ratios in comparison to untreated patients up to TSH levels of 5.0 mIU/l. In conclusion, increasing TSH increases FT3/FT4 ratio even with severe hypothyroidism, less so with aging. With levothyroxine therapy, a ratio similar to untreated patients is achieved at TSH of above 5.0 mIU/l. Since T3 suppresses TSH better than T4, administration of T3 would likely normalize the FT3/FT4 ratio at a lower, ostensibly more physiological, TSH level. This could be seen as a rationale for add-on T3 therapy.
Percutaneous Cement Injection for the Palliative Treatment of Osseous Metastases: A Technical Review
Authors: Tselikas Lambros , Gravel Guillaume , de Baère Thierry , Deschamps Frederic , Yevich Steven 
Published: November 2018

AbstractThe technical art to percutaneous injection of polymethyl methacrylate (PMMA) cement for the palliative treatment of osseous metastases is not without pitfalls. Pathologic fracture, cortical bone erosion, large lytic tumor, aggressive tumor biology, and tumor vascularity may increase the risk of cement leakage or limit complete consolidation. A calculated and determined approach is often necessary to achieve satisfactory patient-tailored results. This article reviews the challenges and potential complications during the consolidation of osseous metastases. Case examples are presented to facilitate early detection of impending cement leakage, minimize procedural risks, and provide management suggestions for complications. Technical pearls are provided to refine consolidative techniques and improve the comprehensive treatment of painful osseous metastases.
Giovanni Alfonso Borelli: The Precursor of Medial Pivot Concept in Knee Biomechanics
Authors: Piolanti Nicola , Polloni Simone , Bonicoli Enrico , Giuntoli Michele , Scaglione Michelangelo , Indelli Pier 
Published: November 2018

AbstractA new philosophy of science and medicine had spread throughout the 17th-century Italy: the “Scientific Revolution.” Giovanni Alfonso Borelli (1608–1679) was one of the most charismatic and brilliant scientists of his generation in Europe. He extended to biology the rigorous analytic methods developed by his indirect mentor Galileo in the field of mechanics. In his masterpiece “De Motu Animalium,” Borelli analyzed structure, motion, balance, and forces concerning almost all the principal joints of the human body, in static and dynamic situations. In particular, he accurately studied the anatomy and biomechanics of the knee joint. He sustained that femoral condyles shift backward during flexion, allowing a wider range of movement. Furthermore, he observed that, when the knee flexes, the lateral condyle moves backward more than the medial condyle: this concept is nowadays known as medial pivoting. The aim of this article is to describe the life and work of this important Italian scientist and to present his unrecognized contribution to modern knee biomechanics.
Estabilización de la luxación inveterada de la quinta articulación carpo-metacarpiana mediante tenosuspensión con banda de extensor cubital del carpo
Authors: Hernández-Cortés Pedro , Rodríguez Laura , Gil María Isabel 
Published: November 2018

ResumenLas fracturas luxaciones de la articulación carpometacarpiana (CMC) del 5° dedo pasan desapercibidas con frecuencia. El diagnóstico y tratamiento tardíos conlleva con frecuencia malos resultados funcionales por dolor, pérdida de fuerza de prensión y el desarrollo de artrosis CMC. El tratamiento de las luxaciones inveteradas es un reto. Se han propuesto numerosas técnicas quirúrgicas al respecto. Presentamos una modificación de una tenoplastia de supensión, utilizando una banda del tendón del Extensor Carpi Ulnaris. Creemos que esa técnica tiene varias ventajas sobre otros procedimientos paliativos. En primer lugar, se preserva la movilidad del 5° metacarpiano que se estabiliza sólo por ligamentoplastia al 4° metacarpiano. En segundo lugar, mantiene la longitud del 5° radio. En tercer lugar, admite una variante en la que la realización de túneles óseos en 4° y 5° metacarpiano favorece una mejor alineación, evitando la disrotación del 5° dedo. Pensamos que esa técnica es el mejor tratamiento en las luxaciones inveteradas de la 5ª articulación CMC.