bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic efficacy of cryotherapy on facial swelling, pain, trismus and quality of life after surgical removal of mandibular third molars: A systematic review
Authors: Larsen Marie Kjærgaard , Kofod Thomas , Starch‐Jensen Thomas 
Published: March 2019

AbstractThe objective was to test the hypothesis of no difference in facial swelling, pain, trismus and immediate quality of life after surgical removal of mandibular third molars, with or without post‐operative cryotherapy. A MEDLINE (PubMed), EMBASE database and Cochrane library search in combination with a hand search of relevant journals were conducted by including human randomised controlled trials published in English until 17 July 2018. The search identified 37 titles. Six studies with low or unclear risk of bias fulfilled the inclusion criteria. Intermittent cryotherapy for 30 minutes during the first post‐operative days significantly diminished facial swelling, pain and trismus compared with no cryotherapy. Patient's satisfaction and perception of recovery were significantly increased with cryotherapy. Therapeutic efficacy of intermittent cryotherapy on post‐operative facial swelling, pain and trismus seems to be improved compared with continuous cryotherapy. Considerable variations in study design, diversity of used evaluation methods, outcome measures and various methodological confounding factors posed serious restrictions to review the literature in a quantitative systematic manner. Thus, conclusions drawn from the results of this systematic review should be interpreted with caution. Further well‐designed randomised controlled trials including standardised protocol, larger patient sample, blinded outcome assessors, patient‐reported outcome measures and three‐dimensional volumetric analysis of facial swelling are required before evidence‐based recommendations can be provided.
Computational aspects of robust optimized certainty equivalents and option pricing
Authors: Bartl Daniel , Drapeau Samuel , Tangpi Ludovic 
Published: March 2019

AbstractAccounting for model uncertainty in risk management and option pricing leads to infinite‐dimensional optimization problems that are both analytically and numerically intractable. In this article, we study when this hurdle can be overcome for the so‐called optimized certainty equivalent (OCE) risk measure—including the average value‐at‐risk as a special case. First, we focus on the case where the uncertainty is modeled by a nonlinear expectation that penalizes distributions that are “far” in terms of optimal‐transport distance (e.g. Wasserstein distance) from a given baseline distribution. It turns out that the computation of the robust OCE reduces to a finite‐dimensional problem, which in some cases can even be solved explicitly. This principle also applies to the shortfall risk measure as well as for the pricing of European options. Further, we derive convex dual representations of the robust OCE for measurable claims without any assumptions on the set of distributions. Finally, we give conditions on the latter set under which the robust average value‐at‐risk is a tail risk measure.
Gastric accommodation measurements by single photon emission computed tomography and two‐dimensional scintigraphy in diabetic patients with upper gastrointestinal symptoms
Authors: Chedid Victor , Halawi Houssam , Brandler Justin , Burton Duane , Camilleri Michael 
Published: March 2019

AbstractObjectiveTo compare estimates of gastric accommodation (GA) with single photon emission computed tomography (SPECT) to measurements based on intragastric meal distribution immediately post‐meal ingestion (IMD0).MethodsWe evaluated 108 diabetics with upper gastrointestinal (UGI) symptoms who had undergone gastric emptying of solids (GE) by scintigraphy and GA measurements by SPECT. Immediately after ingestion of a 99mTc‐labeled egg meal (time 0), we estimated IMD0 as radioactive counts or area of the proximal half of the stomach on two‐dimensional images. Gastric volume (GV) during fasting and after 300 mL Ensure® was measured by SPECT to quantify accommodation volume (AV) or postprandial to fasting volume ratio (GVR). From the measured proximal gastric area, we estimated the volume of proximal stomach (4/3 × π × r3). We performed regression analyses to assess relationships between IMD0 and GA (AV) and GVR.ResultsThere was a significant correlation between area and radioactivity counts in the proximal stomach (r = 0.67, P < 0.001); however, there was considerable interpersonal variation [bias 0.20 (95% CI −0.07, 0.47)]. There were no significant correlations between total GV or AV or VR by SPECT and measurements using IMD0: proximal gastric counts, area, and estimated volume as continuous variables of dichotomized patient groups, based on published cutoff values. There were no significant differences in total gastric area or the IMD0 parameters (% area or % radioactive counts) between those with and without UGI symptoms except for fullness and satiety.ConclusionsIntragastric meal distribution immediately post‐meal ingestion is not significantly correlated with GA measurement by SPECT.
Rosmarinic acid in Canna generalis activates the medial deterrent chemosensory neurone and deters feeding in the tobacco hornworm Manduca sexta
Authors: Simmonds Monique S. J. , Stevenson Philip C. , Hanson Frank E. 
Published: March 2019

AbstractFor all but a very few highly specialized insect feeders, Canna generalis L. (Cannaceae) is unacceptable as a food plant and is a highly potent feeding deterrent for the tobacco hornworm Manduca sexta Johan. (Lepidoptera). The present study describes the isolation of an active deterrent compound, rosmarinic acid (RA) from the ethanol extract of canna leaves. A two‐choice bioassay shows that RA is a feeding deterrent in the concentration range 0.3–3 mm. Bilateral ablation of the oral chemoreceptors eliminates this deterrence. The results reported in the behavioural literature show that only the epipharyngeal sensilla and the medial (but not the lateral) styloconica contribute to this deterrence elicited by canna foliage or extract, and the data obtained in the present study show the same results using RA. Electrophysiological recordings from the medial styloconica show that RA primarily stimulates the ‘deterrent neurone’ in a concentration‐dependent manner with a threshold of approximately 0.03 mm and a peak frequency of 69 spikes s–1 at 0.1 mm RA. An extract of canna leaves elicits similar responses. Adding RA to canna extract does not elicit another class of spikes, indicating that both stimuli activate the same neurone. We discuss the significance of the results with respect to furthering our knowledge about the sensory basis of food selection, and specifically about the range of compounds that stimulate deterrent chemosensitive neurones of lepidopteran larvae.
Seed conglomeration: a disruptive innovation to address restoration challenges associated with small‐seeded species
Authors: Hoose Benjamin W. , Call Ryan S. , Bates Thomas H. , Anderson Rhett M. , Roundy Bruce A. , Madsen Matthew D. 
Published: March 2019

Small‐seeded species are an integral component of many natural systems. However, small‐seeded species are often omitted from restoration projects due to limited flow through seeders, low broadcast distance, and inconsistent seeding rates. To address these problems, we developed a novel technique within a rotary coater that allows for the conglomeration of small, low‐purity seeds using a combination of clay, compost, water, and a polymer binder. We used Wyoming big sagebrush (Artemisia tridentata ssp. wyomingensis), which has a seed size of approximately 1 mm or less, as a model species to evaluate the technology. We demonstrated improved flowability of conglomerates over untreated (control) seeds through measurements of the Hausner ratio (8% decrease), the angle of repose (21% decrease), and delivery through a broadcast seeder. Seeding rates of conglomerated seed were more consistent than control seed over rugged terrain. Conglomerates were also broadcast 2.2 times further than control seed, which may mitigate the overall cost of implementing this technology. Laboratory trials demonstrated that the final germination of conglomerated seed averaged 15% higher than control seed. Field trials at two sites demonstrated that seedling emergence was similar for control and conglomerated seed. With no deleterious effects observed from the conglomeration treatment, additional research is merited for using conglomerates as a platform to apply various additives, such as fungicides, plant growth hormones, fertilizers, and biologicals. The potential outcomes of these strategies may have a significant impact on future seeding attempts by improving seed delivery and increasing overall seeding success.
Management of patients with an advance decision and suicidal behaviour: a systematic review
Authors: Nowland Rebecca , Steeg Sarah , Quinlivan Leah M , Cooper Jayne , Huxtable Richard , Hawton Keith , Gunnell David , Allen Neil , Mackway-Jones Kevin , Kapur Navneet 
Published: March 2019

BackgroundThe use of advance care planning and advance decisions for psychiatric care is growing. However, there is limited guidance on clinical management when a patient presents with suicidal behaviour and an advance decision and no systematic reviews of the extant literature.ObjectivesTo synthesise existing literature on the management of advance decisions and suicidal behaviour.DesignA systematic search of seven bibliographic databases was conducted to identify studies relating to advance decisions and suicidal behaviour. Studies on terminal illness or end-of-life care were excluded to focus on the use of advance decisions in the context of suicidal behaviour. A textual synthesis of data was conducted, and themes were identified by using an adapted thematic framework analysis approach.ResultsOverall 634 articles were identified, of which 35 were retained for full text screening. Fifteen relevant articles were identified following screening. Those articles pertained to actual clinical cases or fictional scenarios. Clinical practice and rationale for management decisions varied. Five themes were identified: (1) tension between patient autonomy and protecting a vulnerable person, (2) appropriateness of advance decisions for suicidal behaviour, (3) uncertainty about the application of legislation, (4) the length of time needed to consider all the evidence versus rapid decision-making for treatment and (5) importance of seeking support and sharing decision-making.ConclusionsAdvance decisions present particular challenges for clinicians when associated with suicidal behaviour. Recommendations for practice and supervision for clinicians may help to reduce the variation in clinical practice.
Outcome of surgical repair of adult digital nerve injury: a systematic review
Authors: Dunlop Rebecca L E , Wormald Justin Conrad Rosen , Jain Abhilash 
Published: March 2019

ObjectivesA systematic review to assess the evidence supporting surgical repair of digital nerve injury versus no repair in adults in terms of clinical outcomes.DesignA Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review with methodology based on the Cochrane Handbook of Systematic Reviews of Interventions.Data sourcesDatabases included OvidMEDLINE, EMBASE, AMED, clinicaltrials.gov and the Cochrane Database of Systematic Reviews, searched from inception until 10 November 2018.Eligibility criteriaAdult digital nerve injury in which either direct repair or no repair was undertaken and an outcome measure was recorded.Data extraction and synthesisStudy data extracted included demographics, injury type and extent, timing, treatment details, outcome data and time points, adverse outcomes, hand therapy and return to work. The National Institute of Health quality assessment tool for case series was used to assess risk of bias.ResultsThirty studies were included. One compared surgical repair with non-repair. All studies were case series of between 15 and 110 nerve injuries, with heterogeneous patient, injury and treatment characteristics. Two studies detailed nerve repair without magnification. Static 2-point discrimination (s2PD) was the most commonly reported outcome measure. Return of protective sensation was achieved in most cases in the nerve repair and no nerve repair groups. Repair resulted in better s2PD than no repair, but <25% repaired nerves achieved normal levels. Adverse outcomes were similar between repair and no repair groups.ConclusionsOnly level IV evidence is available to support surgical repair of digital nerves in adults. Return of normal sensibility is uncommon and almost all unrepaired nerves regained protective sensation by 6 months and all patients declined further surgery. There was no difference in adverse outcomes. There is currently a lack of high-quality evidence to support surgical repair of digital nerve injuries in adults and further research is needed.PROSPERO registration numberCRD42017065092.
Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment
Authors: Suzuki Kota , Oikawa Takuya , Nochioka Kotaro , Miura Masanobu , Kasahara Shintaro , Sato Masayuki , Aoyanagi Hajime , Shiroto Takashi , Takahashi Jun , Miyata Satoshi , Sakata Yasuhiko , Shimokawa Hiroaki 
Published: March 2019

Objective—
Secondary prevention for recurrent myocardial infarction (MI) is one of the most important therapeutic goals in patients with old MI (OMI). Although statins are widely used for this purpose, there remains considerable residual risk even after LDL (low-density lipoprotein cholesterol) is well controlled by statins.

Approach and Results—
We examined clinical impacts of nHDL (nonhigh-density lipoprotein cholesterol) and its major components triglyceride and LDL as residual risks for acute MI recurrence, using the database of our CHART (Chronic Heart Failure Analysis and Registry in the Tohoku District)-2 Study, the largest-scale cohort study of cardiovascular patients in Japan. We enrolled 1843 consecutive old MI patients treated with statins (mean age 67.3 years, male 19.2%) in the CHART-2 Study. The incidence of recurrent acute MI during the median 8.6-year follow-up was compared among the groups divided by the levels of nHDL (<100, 100–129, and ≥130 mg/dL), LDL (<70, 70–99, and ≥100 mg/dL), triglyceride (<84, 84–149, and ≥150 mg/dL), and combination of LDL and triglyceride. Kaplan-Meier curves and multiple Cox proportional hazards models showed that higher levels of nHDL, but not LDL or triglyceride alone, were associated with higher incidence of recurrent acute MI. Furthermore, higher triglyceride levels were associated with higher incidence of recurrent MI in patients with LDL <100 mg/dL but not in those with LDL ≥100 mg/dL.

Conclusions—
These results indicate that management of residual risks for acute MI recurrence should include nHDL management considering both LDL and triglyceride in old MI patients under statin treatment.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00418041.
Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy
Authors: Seners Pierre , Roca Pauline , Legrand Laurence , Turc Guillaume , Cottier Jean-Philippe , Cho Tae-Hee , Arquizan Caroline , Bracard Serge , Ozsancak Canan , Ben Hassen Wagih , Naggara Olivier , Lion Stéphanie , Debiais Séverine , Berthezene Yves , Costalat Vincent , Richard Sébastien , Magni Christophe , Mas Jean-Louis , Baron Jean-Claude , Oppenheim Catherine 
Published: March 2019

Background and Purpose—
In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site and thrombus length, predictors of early post-IVT recanalization are poorly known. Better collaterals might also facilitate ER, for instance, by improving delivery of the thrombolytic agent to both ends of the thrombus. In this proof-of-concept study, we tested the hypothesis that good collaterals independently predict post-IVT recanalization before thrombectomy.

Methods—
Patients from the registries of 6 French stroke centers with the following criteria were included: (1) acute stroke with large vessel occlusion treated with IVT and referred for thrombectomy between May 2015 and March 2017; (2) pre-IVT brain magnetic resonance imaging, including diffusion-weighted imaging, T2*, MR angiography, and dynamic susceptibility contrast perfusion-weighted imaging; and (3) ER evaluated ≤3 hours from IVT start on either first angiographic run or noninvasive imaging. A collateral flow map derived from perfusion-weighted imaging source data was automatically generated, replicating a previously validated method. Thrombus length was measured on T2*-based susceptibility vessel sign.

Results—

Of 224 eligible patients, 37 (16%) experienced ER. ER occurred in 10 of 83 (12%), 17 of 116 (15%), and 10 of 25 (40%) patients with poor/moderate, good, and excellent collaterals, respectively. In multivariable analysis, better collaterals were independently associated with ER (
P
=0.029), together with shorter thrombus (
P
<0.001) and more distal occlusion site (
P
=0.010).

Conclusions—
In our sample of patients with stroke imaged with perfusion-weighted imaging before IVT and intended for thrombectomy, better collaterals were independently associated with post-IVT recanalization, supporting our hypothesis. These findings strengthen the idea that advanced imaging may play a key role for personalized medicine in identifying patients with large vessel occlusion most likely to benefit from IVT in the thrombectomy era.
Neo-Mandaic in Early Mandaean Colophons. Part 2: Texts, Translations and Conclusion
Authors: Morgenstern Matthew 
Published: March 2019

Abstract
The first part of this article examined the features that distinguish the language of the earliest Mandaean colophons from Classical Mandaic and demonstrated that many of these features are shared with the contemporary Neo-Mandaic dialects recorded in the research literature since the 20th century. Part 2 presents editions and translations of the source texts with some brief philological notes and seeks to identify the origins of the linguistic innovations.
Weighted Visual and Vestibular Cues for Spatial Updating During Passive Self-Motion
Authors: Koppen Mathieu , ter Horst Arjan C. , Medendorp W. Pieter 
Published: March 2019

Abstract
When walking or driving, it is of the utmost importance to continuously track the spatial relationship between objects in the environment and the moving body in order to prevent collisions. Although this process of spatial updating occurs naturally, it involves the processing of a myriad of noisy and ambiguous sensory signals. Here, using a psychometric approach, we investigated the integration of visual optic flow and vestibular cues in spatially updating a remembered target position during a linear displacement of the body. Participants were seated on a linear sled, immersed in a stereoscopic virtual reality environment. They had to remember the position of a target, briefly presented before a sideward translation of the body involving supra-threshold vestibular cues and whole-field optic flow that provided slightly discrepant motion information. After the motion, using a forced response participants indicated whether the location of a brief visual probe was left or right of the remembered target position. Our results show that in a spatial updating task involving passive linear self-motion humans integrate optic flow and vestibular self-displacement information according to a weighted-averaging process with, across subjects, on average about four times as much weight assigned to the visual compared to the vestibular contribution (i.e., 79% visual weight). We discuss our findings with respect to previous literature on the effect of optic flow on spatial updating performance.
Dimensions of personal meaning from engagement in occupations: A metasynthesis
Authors: Roberts Anne E. K. , Bannigan Katrina 
Published: March 2019

Background. Occupational scientists have offered various theoretical propositions regarding the dimensions of meaning derived from engagement in occupations, and empirical studies have explored the personal meaning of engaging in a wide range of occupations. Purpose. The study aimed to distil the dimensions of personal meaning from existing research, with a view to informing theory in this area. Method. A qualitative metasynthesis of research studies was conducted, focusing on research reporting individuals’ accounts of the personal meaning of an occupation to them. Twenty papers met the search criteria and were reviewed, rated for quality, analyzed, and synthesized following a process of meta-aggregation. Findings. There were four common dimensions of personal meaning: a sense of fulfilment; a sense of restoration; social, cultural, and intergenerational connection; and identity shaping. Implications. This review provides occupational therapists with sound evidence of the link between engagement in a meaningful occupation and a sense of personal and social well-being.
Self-perceived occupational performance of community-dwelling adults living with stroke
Authors: Jaber Ala’a F. , Sabata Dory , Radel Jeff D. 
Published: March 2019

Background. Stroke has long-term consequences for functional performance of daily activities. Evaluating client-perceived occupational performance provides insight for designing stroke-specific programs supporting home and community participation. Purpose. This study describes the personal characteristics and self-perceived occupational performance in community-dwelling adults with stroke. Method. A retrospective chart review was undertaken of 25 stroke survivors who sought services at a community-based centre. The outcome measures were the Canadian Occupational Performance Measure (COPM) to evaluate self-perceived occupational performance and the Montreal Cognitive Assessment (MoCA) to screen for cognitive impairment. The analysis used descriptive statistics. Findings. Mean participant age was 64 years, and most participants were Caucasian males (72%). The mean cognitive function score was 22.1 on MoCA, and the mean COPM performance and satisfaction subscores were 4.1 and 3.9, respectively. The top three challenging daily activities were driving, seeking employment, and functional mobility. Implications. Stroke-specific community programs should emphasize the diverse performance concerns important to stroke survivors.
Relationship between body functions and Arabic handwriting performance at different acquisition stages
Authors: Salameh-Matar Abeer , Basal Naser , Weintraub Naomi 
Published: March 2019

Background. The written languages and handwriting acquisition stages place different demands on the writer. Therefore, the relationship between body functions and handwriting performance may vary in different languages and acquisition stages; yet these demands have not been studied in the Arabic language. Purpose. We examined the relationship between linguistic, visual-motor integration (VMI), and motor coordination (MC) functions and Arabic handwriting at two handwriting acquisition stages. Method. This study used a cross-sectional and correlative design. Second- ( n = 54) and fourth-grade ( n = 59) students performed tasks examining reading, handwriting automaticity, VMI, MC, and copying a text. Findings. Handwriting automaticity significantly explained the variance in handwriting speed in both grades, in addition to the VMI in second grade and the MC in fourth grade. Enhanced performance in the VMI increased the likelihood of having good legibility in second but not in fourth grade. Implications. Similar to other languages, the body functions related to Arabic handwriting vary at the different acquisition stages. Handwriting evaluation should be adjusted to students’ acquisition stage.