bluuebunny/crossref_metadata_2025_split huggingface dataset:
McArdle disease causing rhabdomyolysis following vaginal delivery
Authors: McMillan B. M. , Hirshberg J. S. , Cosgrove S. C. 
Published: August 2019

SummaryMcArdle disease (glycogen storage disease type V) is a rare, autosomal recessive disorder with an incidence of roughly 1:100,000. Despite concern that labour could predispose these patients to muscle damage, there are no evidence‐based guidelines for the management of labour and delivery in this population. We describe the case of a nulliparous parturient with both McArdle disease and adenosine monophosphate deaminase 1 deficiency who developed rhabdomyolysis after vaginal delivery. In the absence of common triggers, we believe that prolonged pushing efforts contributed to the increase in postpartum creatinine kinase. There are no previous cases of postpartum rhabdomyolysis after caesarean or assisted vaginal delivery within 45 min. We recommend that practitioners be alert to the possibility of rhabdomyolysis occurring with greater than 2 h of pushing efforts in parturients with McArdle disease.
Synthesis, XRD, spectral (IR, UV–Vis, NMR) characterization and quantum chemical exploration of benzoimidazole‐based hydrazones: A synergistic experimental‐computational analysis
Authors: Rafiq Muhammad , Khalid Muhammad , Tahir Muhammad Nawaz , Ahmad Muhammad Umair , Khan Muhammad Usman , Naseer Muhammad Moazzam , Braga Ataualpa Albert Carmo , Muhammad Shabbir , Shafiq Zahid 
Published: August 2019

Present study advocates the joint experimental and computational studies of two potent benzoimidazole‐based hydrazones with chemical formula C23H18F2N4O (5a) and C25H22FN5O3 (5b). Both 5a and 5b were synthesized and resolved into their crystal structures using SC‐XRD for the assessment of bond lengths, bond angles, unit cells and space groups. The structures of 5a and 5b were chemically characterized using infrared (FT‐IR), UV–Visible, nuclear magnetic resonance (1H‐NMR and 13C‐NMR), EIMS and elemental analysis. DFT at M06‐2X/6‐31G(d,p) level of theory was performed to get optimized structures and countercheck the experimental findings. Overall, DFT findings show excellent concurrence with the experimental data which confirms the purity of both compounds. FMO, NBO analysis, MEP surfaces and nonlinear optical (NLO) properties were explored at same level of theory. UV–Vis analysis at TDDFT/M06‐2X/6‐31G(d,p) level of theory showed that 5b is red shifted with λmax 331.69 nm as compared to 5a with λmax 240.25 nm. Global reactivity parameters were estimated using energy of FMOs indicated the greater harness value than the softness values of 5a and 5b. NBO analysis confirmed that the presence of non‐covalent interactions, hydrogen bonding and hyper conjugative interactions are pivotal cause for the existence of 5a and 5b in the solid‐state. NLO results of 5a and 5b were observed better than standard molecule recommended the NLO activity of said molecules for optoelectronic applications.
Recovery of ammonia nitrogen and magnesium as struvite from wastewaters in coal‐fired power plant
Authors: Zhao Xiaodan , Tu Chengqin , Zhou Zhen , Zhang Wei , Ma Xu , Yang Jiazhe 
Published: August 2019

AbstractThis paper describes a cost‐effective method for recovering ammonia nitrogen (NH4+‐N) from regeneration wastewater by using magnesium recovered from flue‐gas desulfurization (FGD) wastewater in the same coal‐fired power plant. Mg2+ was efficiently removed from FGD wastewater at pH of 11, and the settling performance of Mg (OH)2 was evidently improved by adding anionic polyacrylamide and crystal seed. For NH4+‐N removal optimization by response surface methodology, the results indicated that the molar ratio of phosphorus to nitrogen (P/N) was the more dominant parameter, and the optimum conditions were predicted at Mg/N of 1.1 and P/N of 0.7. At the optimum conditions, the predicted data of NH4+‐N removal efficiency (NRE) and residue phosphorus were 71.41% and 21.90 mg/L, and actual experimental data were 72.12% and 19.60 mg/L. The inhibitory effect of NaCl concentration on NRE matches the modified Monod model with half inhibition concentration of 89.01 g/L. Morphologic analysis confirmed that salinity inhibited the formation and growth of struvite crystals.
Indirect connectivity estimates of amphibian breeding wetlands from spatially explicit occupancy models
Authors: Brooks George C. , Smith Jennifer A. , Frimpong Emmanuel A. , Gorman Thomas A. , Chandler Houston C. , Haas Carola A. 
Published: August 2019

AbstractIn conservation science, metapopulation models are frequently used to explore the spatial dynamics of organisms, and ultimately guide management decisions for threatened and endangered species. Pond‐breeding amphibians are often touted as a classic example of metapopulation structure. However, empirical assessment of this assumption is lacking for many species owing to the prohibitively high costs of movement studies. Our aim was to use spatially explicit occupancy models to evaluate metapopulation dynamics in an endangered amphibian.First, dynamic, spatially explicit occupancy‐based metapopulation models were fitted to 8 years of presence–absence data for the endangered reticulated flatwoods salamander,Ambystoma bishopi. Models were constructed to evaluate the spatial distribution of salamanders across the landscape, rate of patch turnover, and connectivity between patches. Second, the same data were analysed adopting an eigenvector mapping approach and spatial correlograms to investigate habitat characteristics associated with occupancy state. The second approach also yields an independent measure of patch connectivity to corroborate findings from the dynamic model.Both models predicted a steep drop‐off in connectivity with increasing isolation, and no evidence was found of interactions between wetlands separated by distances greater than 1.5 km. The best predictor of salamander occupancy status was the amount of understorey vegetation in wetland basins.Taken together, the two modelling approaches provide complementary information regarding the key determinants of occupancy in the focal species. Furthermore, several results directly translate to management recommendations. Connectivity between distant sites is low, and thus management units should be demarcated accordingly. Understorey vegetation represents egg‐laying habitat and refugia for larvae, and hence should be targeted in future restoration efforts. The methodologies employed in this paper have broad applicability to studies of pond‐breeding amphibians, particularly in situations where direct measures of dispersal are unobtainable.
A geophysical analysis of Aboriginal earth mounds in the Murray River Valley, South Australia
Authors: Ross Dave , Morrison Michael , Simyrdanis Kleanthis , Roberts Amy , Moffat Ian ,   The River Murray and Mallee Aboriginal Corporation
Published: August 2019

AbstractEarth mounds are common archaeological features in some regions of Australia, particularly within the Murray‐Darling Basin. These features are generally considered to have formed via the repeated use of earth oven cookery methods employed by Aboriginal people during the mid‐ to late‐Holocene. This study assesses the relative effectiveness of key geophysical methods including magnetometry, ground‐penetrating radar (GPR) and electrical resistivity tomography (ERT) in mapping, and determining the stratigraphy of earth mound sites. Three earth mounds adjacent to Hunchee Creek, on Calperum Station in South Australia's Riverland region, were chosen to conduct a comparative trial of these methods. This research demonstrated that geophysics can be used to both locate mounds and provide information as to deposit thickness and size. Individual ovens within mounds can also be located. This suggests a greater potential role for geophysics in understanding the Holocene archaeological record in Australia.
MnO2@Fe3O4 Magnetic Nanoparticles as Efficient and Recyclable Heterogeneous Catalyst for Benzylic sp3 C−H Oxidation
Authors: Pandey Akanksha M. , Agalave Sandip G. , Vinod Chathakudath P. , Gnanaprakasam Boopathy 
Published: August 2019

AbstractHerein, we report a highly chemoselective and efficient heterogeneous MnO2@Fe3O4 MNP catalyst for the oxidation of benzylic sp3 C−H group of ethers using TBHP as a green oxidant to afford ester derivatives in high yield under batch/continuous flow module. This catalyst was also effective for the benzylic sp3 C−H group of methylene derivatives to furnish the ketone in high yield which can be easily integrated into continuous flow condition for scale up. The catalyst is fully characterized by spectroscopic techniques and it was found that 0.424 % MnO2@Fe3O4 catalyzes the reaction; the magnetic nanoparticles of this catalyst could be easily recovered from the reaction mixture. The recovered catalyst was recycled for twelve cycles without any loss of the catalytic activity. The advantages of MnO2@Fe3O4 MNP are its catalytic activity, easy preparation, recovery, and recyclability, gram scale synthesis with a TOF of up to 14.93 h−1 and low metal leaching during the reaction.
Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex
Authors: Dickinson Abigail , Varcin Kandice J. , Sahin Mustafa , Nelson Charles A. , Jeste Shafali S. 
Published: August 2019

Tuberous sclerosis complex (TSC) is a rare genetic disorder that confers a high risk for autism spectrum disorders (ASD), with behavioral predictors of ASD emerging early in life. Deviations in structural and functional neural connectivity are highly implicated in both TSC and ASD. For the first time, we explore whether electroencephalographic (EEG) measures of neural network function precede or predict the emergence of ASD in TSC. We determine whether altered brain function (a) is present in infancy in TSC, (b) differentiates infants with TSC based on ASD diagnostic status, and (c) is associated with later cognitive function. We studied 35 infants with TSC (N = 35), and a group of typically developing infants (N = 20) at 12 and 24 months of age. Infants with TSC were later subdivided into ASD and non‐ASD groups based on clinical evaluation. We measured features of spontaneous alpha oscillations (6–12 Hz) that are closely associated with neural network development: alpha power, alpha phase coherence (APC), and peak alpha frequency (PAF). Infants with TSC demonstrated reduced interhemispheric APC compared to controls at 12 months of age, and these differences were found to be most pronounced at 24 months in the infants who later developed ASD. Across all infants, PAF at 24 months was associated with verbal and nonverbal cognition at 36 months. Associations between early network function and later neurodevelopmental and cognitive outcomes highlight the potential utility of early scalable EEG markers to identify infants with TSC requiring additional targeted intervention initiated very early in life. Autism Res 2019, 12: 1758–1773. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryApproximately half of infants with tuberous sclerosis complex (TSC) develop autism. Here, using EEG, we find that there is a reduction in communication between brain regions during infancy in TSC, and that the infants who show the largest reductions are those who later develop autism. Being able to identify infants who show early signs of disrupted brain development may improve the timing of early prediction and interventions in TSC, and also help us to understand how early brain changes lead to autism.
Social cognition as a predictor of functional and social skills in autistic adults without intellectual disability
Authors: Sasson Noah J. , Morrison Kerrianne E. , Kelsven Skylar , Pinkham Amy E. 
Published: August 2019

Autistic adults, including those without intellectual disability, commonly experience poor social and functional outcomes. Although reduced social cognitive ability in autism is often theorized as a mechanism of these poor outcomes, there has been surprisingly little empirical work testing this assumption. Here, 103 autistic adults without intellectual disability completed a comprehensive battery that included eight social cognitive tasks psychometrically validated for use with this population (e.g., emotion recognition and theory of mind), five tasks assessing neurocognitive abilities (e.g., processing speed and working memory), performance‐based measures of their functional skills, and a standardized assessment of their social skills. Collectively, the combination of demographic variables, IQ, neurocognitive performance, and social cognitive performance accounted for 49% of the variance in functional skills and 33% of the variance in social skills. For functional skills, demographic variables, and general and neurocognition independently accounted for a significant portion of the variance, but social cognition did not. Social cognition did, however, significantly mediate the effect of neurocognition on functional skills. Social cognition also accounted for significant proportion in the variance in social skills above and beyond the relatively large contribution of neurocognition. Taken together, findings indicate that social cognitive ability contributes to functional and social skills in autistic adults without intellectual disability, but this contribution may be more limited and indirect than commonly assumed. Autism Res 2020, 13:259–270. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryMany social programs for autistic adults presume that improving social cognition will translate to better life outcomes. In this study of 103 autistic adults without intellectual disability, we found that social cognitive abilities do contribute to real‐world social and daily living skills, but this contribution is small and indirect once general‐cognitive abilities are taken into account. Although results substantiate social cognition as an independent cognitive capacity in autism spectrum disorder, its unique contribution to functional and social outcomes may be more limited than previously assumed.
Experimentelle, analytische und numerische Untersuchungen zur Verdichtungsprognose von Sand bei der Rütteldruckverdichtung
Authors: Kimmig Ivo , Triantafyllidis Theodoros , Knittel Lukas 
Published: August 2019

AbstractLocker gelagerte nichtbindige Böden werden in zahlreichen Anwendungsfällen erfolgreich durch den Einsatz von Tiefenrüttlern bei der Rütteldruckverdichtung verbessert. Eine verlässliche, physikalisch fundierte Prognose des Verdichtungserfolgs kann für die wirtschaftliche Umsetzung der Maßnahmen jedoch entscheidend sein. Die Ausbreitung von seismischen Wellen, großräumige, plastische Verformungen, Porenwasserdruckaufbau und Materialtransport infolge der Bewegung des Tiefenrüttlers bestimmen den Verdichtungserfolg maßgeblich, können aber in ihrer Gesamtheit bei Simulationen nicht berücksichtigt werden. Zur Verbesserung der Prognosequalität wird ein Vorgehen vorgeschlagen, bei welchem zunächst eine mehrdimensionale Dehnungsamplitude zur Beschreibung der auftretenden Verformungen berechnet und anschließend die Akkumulation der Verformungen infolge einer Vielzahl von Zyklen (Rotationen des Rüttlers) mit einem Akkumulationsmodell abgeschätzt wird. Dazu stehen analytische und numerische Ansätze zur Verfügung, welche einen begrenzten Bodenbereich um den Tiefenrüttler betrachten und vergleichbare, plausible Ergebnisse sowohl für die Wellenausbreitung als auch für die Dehnungsamplitude liefern. Zur Untersuchung des Verformungsverhaltens eines Sands bei Dehnungsamplituden bis in den Prozentbereich wurden Hohlzylindertriaxialversuche mit einer zyklischen Verdrehung der Fußplatte durchgeführt, welche ein überwiegend homogenes Dehnungsfeld zeigten. Durch die Nachrechnung der Laborversuche mit einem Akkumulationsmodell für große Dehnungsamplituden und Anpassung der Modellparameter ist es möglich, das Verformungsverhalten im Falle der Rütteldruckverdichtung zu beschreiben und durch Erweiterung des Vorgehens für die Abschätzung des Rastermaßes zu verwenden.
Minimal impact of hepatic and renal impairment on plasma protein binding of lenvatinib, and identification of its major plasma binding protein
Authors: Mano Yuji , Mizuo Hitoshi 
Published: August 2019

AbstractPlasma protein binding (PPB) can be different depending on the status of hepatic or renal functions. In this study, the PPB of lenvatinib was determined using equilibrium dialysis in plasma from healthy volunteers and from subjects with mild, moderate, or severe hepatic impairment or renal impairment. Plasma from these subjects, fortified with lenvatinib at four concentrations (20, 200, 500, or 1200 ng/ml), was dialysed against phosphate buffered saline (PBS), and then determinations of the total concentrations of lenvatinib in plasma and unbound concentrations in PBS were made. In addition, the binding of lenvatinib was determined in human serum albumin (HSA), α1‐acid glycoprotein (AAG), and human γ‐globulin (HG) in order to identify major binding proteins in human plasma. The PPB of lenvatinib in subjects with HI or RI ranged from 97.5% to 98.2% in hepatic impairment and 98.0% to 98.4% in renal impairment, which was similar to that of healthy volunteers. The binding of lenvatinib to HSA, AAG, and HG was 96.6%–97.1%, 46.4%–69.9%, and 19.1%–23.9%, respectively. These findings suggest that lenvatinib mainly binds to HSA and neither renal nor hepatic impairment impacts the PPB of lenvatinib.
Holoprosencephaly: A case series from an area with high mining‐related pollution
Authors: Kayembe‐Kitenge Tony , Kasole Lubala Toni , Musa Obadia Paul , Katoto Chimusa Patrick , Katshiez Nawej Cyrille , Banza Lubaba Nkulu Célestin , Devriendt Koenraad , Nemery Benoit 
Published: August 2019

AbstractBackgroundThe extraction and processing of copper and cobalt in the African Copperbelt in the Democratic Republic of Congo have led to substantial environmental pollution, causing concerns about possible adverse effects on human health, including birth defects.CasesWe report three neonates with clinically diagnosed holoprosencephaly who were part of a case–control study performed in Lubumbashi between February 2013 and February 2015. One mother had a high concentration of uranium in urine, and high manganese concentrations were found in blood of another mother and in cord blood of one infant. Two of the three fathers had a mining‐related job.DiscussionWe hypothesize that these cases of holoprosencephaly were connected to mining‐related pollution, possibly via epigenetic alterations induced by paternal occupational exposure to toxic metals.
Wesentliche Aspekte bei der Planung integraler Brücken
Authors: della Pietra Regina , Oberwalder Stefan , Tue Nguyen Viet 
Published: August 2019

AbstractDa es sich bei Integralbrücken um Rahmentragwerke handelt, sind bei der Bemessung einige Besonderheiten zu beachten. Ein wesentlicher Aspekt ist die Beanspruchung infolge Temperatur‐ und Erddrucklasten sowie deren Interaktion in Abhängigkeit von der Tragwerks‐ und der Gründungssteifigkeit, welche in diesem Beitrag untersucht wird. Aufbauend auf diesen Erkenntnissen wird die Auswirkung von Weicheinlagen hinter der Widerlagerwand bzw. im Pfahlkopfbereich im Fall von Tiefgründungen auf die Beanspruchung im Tragwerk beurteilt. Als letzter Punkt wird der Übergang zwischen Brückentragwerk und Straße betrachtet und dessen besondere Anforderungen im integralen Brückenbau aufgezeigt.
Preparation and application of solvent‐modulated self‐doped N–S multicolour fluorescence carbon quantum dots
Authors: Xu Jun , Li Jinkai , Wang Congling , Zhao Weilin 
Published: August 2019

AbstractIn this paper, two types of carbon quantum dot (CQDs) were prepared using biocompatible l‐methionine as the carbon source and urea as the nitrogen source and a one‐step hydrothermal treatment. By changing the reaction solvents (deionized (DI) water and dimethylformamide (DMF)), the maximum emission of the resulting CQDs shifted from blue to red light. Specifically, the emission wavelength of the CQDs moved from 433 nm to 625 nm following embedding of a new functional group (–CONH–) on the surface of the CQDs. Photoluminescence quantum yields of the CQDs with blue and red emission reached 64% and 61%, respectively. The R‐CQDs were used to detect metal ions and a linear relationship was demonstrated between ln(F/F0) and Fe3+ concentration in the range 0–0.5 mmol/L with a detection limit of 0.067 μM. Therefore these R‐CQDs have great potential as fluorescent probes for Fe3+ detection. We expect that the excellent water‐soluble, biocompatible and optical properties of the CQDs developed in this work mean that they will be widely used to detect biological cells.
Secondary technical resectability of colorectal cancer liver metastases after chemotherapy with or without selective internal radiotherapy in the randomized SIRFLOX trial
Authors: Garlipp B , Gibbs P , Van Hazel G A , Jeyarajah R , Martin R C G , Bruns C J , Lang H , Manas D M , Ettorre G M , Pardo F , Donckier V , Benckert C , Gulik T M , Goéré D , Schoen M , Pratschke J , Bechstein W O , Cuesta A M , Adeyemi S , Ricke J , Seidensticker M 
Published: August 2019

Abstract

Background
Secondary resection of initially unresectable colorectal cancer liver metastases (CRLM) can prolong survival. The added value of selective internal radiotherapy (SIRT) to downsize lesions for resection is not known. This study evaluated the change in technical resectability of CRLM with the addition of SIRT to FOLFOX-based chemotherapy.

Methods
Baseline and follow-up hepatic imaging of patients who received modified FOLFOX (mFOLFOX6: fluorouracil, leucovorin, oxaliplatin) chemotherapy with or without bevacizumab (control arm) versus mFOLFOX6 (with or without bevacizumab) plus SIRT using yttrium-90 resin microspheres (SIRT arm) in the phase III SIRFLOX trial were reviewed by three or five (of 14) expert hepatopancreatobiliary surgeons for resectability. Reviewers were blinded to one another, treatment assignment, extrahepatic disease status, and information on clinical and scanning time points. Technical resectability was defined as at least 60 per cent of reviewers (3 of 5, or 2 of 3) assessing a patient's liver metastases as surgically removable.

Results
Some 472 patients were evaluable (SIRT, 244; control, 228). There was no significant baseline difference in the proportion of technically resectable liver metastases between SIRT (29, 11·9 per cent) and control (25, 11·0 per cent) arms (P = 0·775). At follow-up, significantly more patients in both arms were deemed technically resectable compared with baseline: 159 of 472 (33·7 per cent) versus 54 of 472 (11·4 per cent) respectively (P = 0·001). More patients were resectable in the SIRT than in the control arm: 93 of 244 (38·1 per cent) versus 66 of 228 (28·9 per cent) respectively (P &lt; 0·001).

Conclusion
Adding SIRT to chemotherapy may improve the resectability of unresectable CRLM.
Communicating environmental management certification: Signaling without signals?
Authors: Heras‐Saizarbitoria Iñaki , Boiral Olivier , Allur Erlantz , García María 
Published: August 2019

AbstractThis article analyzes how organizations communicate their voluntary environmental management certification. Previous research suggests that firms use certification to signal and to create a better public image as one of their main objectives in adopting environmental management standards. How organizations communicate their certification to their stakeholders has not been fully researched. To fill this gap, this work focuses on the hospitality industry, one of the most relevant sectors for environmental certification, and Eco‐Management and Audit Scheme, one of the most demanding certification schemes. On the basis of the analysis of the communication practices of 201 certified European hotels and 37 interviews with managers from certified hotels, the findings are surprising. The great majority of organizations included in the study engage in no significant communication activity. The results cast doubt in the idea that improving corporate image is one of the main drivers to adopt third‐party voluntary certification.