bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salvage open partial horizontal laryngectomy after failed radiotherapy: A multicentric study
Authors: Bertolin Andy , Lionello Marco , Ghizzo Marco , Cena Isida , Leone Federico , Valerini Sara , Mattioli Francesco , Crosetti Erika , Presutti Livio , Succo Giovanni , Rizzotto Giuseppe 
Published: May 2019

ObjectivesThe primary aim of the present study was to report our multi‐institutional experience in surgical salvage with open partial horizontal laryngectomies (OPHL) after failed radiotherapy (RT) for laryngeal squamous cell carcinoma (LSCC). Secondary aims were to analyze the prognostic meaning of the main clinical and pathological parameters in relation to the oncologic outcome and to compare our results with the available literature.Study DesignA retrospective multicenter analysis of surgical oncological outcomes.MethodsWe retrospectively review the clinical charts of 70 recurrent LSCC patients after primary RT failure undergone salvage OPHL.ResultsAt last follow‐up, 46 patients (65%) were disease‐free; six (9%) were alive with disease; nine (12%) died because of the disease; and nine (12%) died without evidence of disease. The final local control, overall survival, disease‐specific survival, and laryngectomy‐free survival were 87%, 75%, 87%, and 91%, respectively. Twelve patients (17%) experienced postoperative complications, whereas 18 patients (25%) experienced late sequelae. In five patients (7%), decannulation was not possible because of postoperative laryngeal stenosis.ConclusionIn selected patients, when proper selection criteria for conservation laryngeal surgery are adopted, OPHL can be considered for salvage after RT failure.Level of Evidence4 Laryngoscope, 130:431–436, 2020
The first omitting cardinal for Magidority
Authors: Garti Shimon , Hayut Yair 
Published: May 2019

AbstractAn infinite cardinal λ is Magidor if and only if . It is known that if λ is Magidor then for some , and the first such α is denoted by . In this paper we try to understand some of the properties of . We prove that can be the successor of a supercompact cardinal, when λ is a Magidor cardinal. From this result we obtain the consistency of being a successor of a singular cardinal with uncountable cofinality.
Inhibition of cyclin E1 overcomes temozolomide resistance in glioblastoma by Mcl‐1 degradation
Authors: Liang Huaxin , Chen Zhuo , Sun Libo 
Published: May 2019

AbstractGlioblastoma (GBM) is one of the major causes of brain cancer‐related mortality worldwide. Temozolomide (TMZ) is an important agent against GBM. Acquired TMZ‐resistance severely limits the chemotherapeutic effect and leads to poor GBM patient survival. To study the underlying mechanism of drug resistance, two TMZ resistant GBM cell lines, A172 and U87, were generated. In this study, the TMZ resistant cells have less apoptosis and cell‐cycle change in response to the TMZ treatment. Western blot results revealed that cyclin E1 was upregulation in TMZ resistant cells. Inhibition or depletion of cyclin E1 re‐sensitized the resistant cells to the TMZ treatment, which indicated the induction of cyclin E1 is the cause of TMZ resistance in GBM cells. Furthermore, we also found the expression of cyclin E1 stabilized the expression of Mcl‐1, which contributes to the TMZ resistance in GBM cells. Finally, our in vivo xenograft data showed that the combination of flavopiridol, a cyclin E1/CDK2 inhibitor, overcomes the TMZ resistant by inducing higher apoptosis. Overall, our data provided a rationale to overcome the TMZ resistant in GBM treatment by inhibiting the cyclin E1 activity.
A GRAPPA algorithm for arbitrary 2D/3D non‐Cartesian sampling trajectories with rapid calibration
Authors: Luo Tianrui , Noll Douglas C. , Fessler Jeffrey A. , Nielsen Jon‐Fredrik 
Published: May 2019

PurposeGRAPPA is a popular reconstruction method for Cartesian parallel imaging, but is not easily extended to non‐Cartesian sampling. We introduce a general and practical GRAPPA algorithm for arbitrary non‐Cartesian imaging.MethodsWe formulate a general GRAPPA reconstruction by associating a unique kernel with each unsampled k‐space location with a distinct constellation, that is, local sampling pattern. We calibrate these generalized kernels using the Fourier transform phase shift property applied to fully gridded or separately acquired Cartesian Autocalibration signal (ACS) data. To handle the resulting large number of different kernels, we introduce a fast calibration algorithm based on nonuniform FFT (NUFFT) and adoption of circulant ACS boundary conditions. We applied our method to retrospectively under‐sampled rotated stack‐of‐stars/spirals in vivo datasets, and to a prospectively under‐sampled rotated stack‐of‐spirals functional MRI acquisition with a finger‐tapping task.ResultsWe reconstructed all datasets without performing any trajectory‐specific manual adaptation of the method. For the retrospectively under‐sampled experiments, our method achieved image quality (i.e., error and g‐factor maps) comparable to conjugate gradient SENSE (cg‐SENSE) and SPIRiT. Functional activation maps obtained from our method were in good agreement with those obtained using cg‐SENSE, but required a shorter total reconstruction time (for the whole time‐series): 3 minutes (proposed) vs 15 minutes (cg‐SENSE).ConclusionsThis paper introduces a general 3D non‐Cartesian GRAPPA that is fast enough for practical use on today’s computers. It is a direct generalization of original GRAPPA to non‐Cartesian scenarios. The method should be particularly useful in dynamic imaging where a large number of frames are reconstructed from a single set of ACS data.
An Analysis of the DisplayHDR Compliance Specification and Its DisplayHDR True Black Specification Extension
Authors: Stolitzka Dale 
Published: May 2019

AbstractThe VESA DisplayHDR High‐Performance Monitor and Display Compliance Test Specification, along with its extension for emissive pixel displays–DisplayHDR True Black, create a minimum acceptance level for HDR performance in monitors, notebooks, and all‐in‐one computer products. Here, we examine associated specifications tests, while quantifying performance against the CIECAM02 color appearance and SEMI Perceptual Contrast Length models.
Trendbericht Physikalische Chemie
Authors: Wächtler Maria 
Published: May 2019

AbstractWie effizient photokatalytische Wasserstofferzeugung abläuft, hängt von Elektronen‐ und Lochtransferprozessen ab. Diese lassen sich besonders gut an Halbleiternanokristallen untersuchen. Cadmiumchalkogenide liefern die Modellsysteme.
ClF3 – von der „Wunderwaffe“ zum Laborexoten
Authors: Kraus Florian 
Published: May 2019

AbstractNiemand kommt im Chemiestudium um die Valenzstrichformel von Chlortrifluorid herum – und mehr Gedanken macht sich darüber in der Regel keiner. Dabei birgt der Stoff, den Otto Ruff Anfang des 20. Jahrhunderts bei seinen Forschungen an Interhalogenverbindungen entdeckte, explosives Potenzial.
The role of urodynamics in the management of female stress urinary incontinence
Authors: Serati Maurizio , Braga Andrea , Torella Marco , Soligo Marco , Finazzi‐Agro Enrico 
Published: May 2019

AimThe role of urodynamic study (UDS) in the management of female stress urinary incontinence (SUI) is one of the most controversial and debated topic in urogynecology. Here, we aimed to systematically assess the most relevant available evidence on urodynamics’ value in the management of women with stress urinary incontinence.MethodsA systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Statement was performed in May 2018. Only randomized clinical trials, prospective studies, or retrospective studies articles evaluating the use of urodynamic studies in women with stress urinary incontinence were included.ResultsAfter screening a total of 3055 records, 39 studies published from 1996 to 2018 were included.ConclusionsIn an uncomplicated population of women with SUI, it is not demonstrated that preoperative urodynamic evaluation can improve the outcome of continence surgery; however, UDS provides additional information regarding lower urinary tract function that could guide the physician to make the right therapeutic choice. UDS should be considered mandatory before surgery in complicated patients, but its use should also be evaluated in index patients when the results may help counseling and management of these women.
Mucosal lesions in cutaneous lupus erythematosus successfully treated with hydroxychloroquine
Authors: Kamaguchi Mayumi , Iwata Hiroaki , Asaka Takuya , Shimizu Hiroshi , Kitagawa Yoshimasa 
Published: May 2019

AbstractCutaneous lupus erythematosus (CLE) is a rare, potentially disfiguring, chronic autoimmune disease with extremely variable skin and mucosal membrane manifestations. Hydroxychloroquine (HCQ) is an antimalarial drug that has been used in various countries to treat autoimmune diseases including CLE. HCQ was banned for a long time in Japan because of severe chloroquine retinopathy and was reapproved as a first‐line treatment for CLE in 2015. There are no case reports describing the effectiveness of HCQ for CLE with oral mucosal lesions in the dental field. We present a case of CLE whose oral lesions were successfully treated with HCQ.
The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness
Authors: Abdollahi Abbas , Panahipour Hannaneh , Hosseinian Simin , Allen Kelly A. 
Published: May 2019

AbstractObjectiveDiagnosis and treatment of breast cancer are psychologically stressful events, and hope and hardiness have been found to be important constructs for women with breast cancer. Therefore, this research sought to examine the relationships of perceived stress and hardiness with hope, and the buffering role of hardiness in the link between perceived stress and hope among Iranian women with breast cancer.MethodsTwo hundred and twenty Iranian women with breast cancer from three hospitals completed online measures evaluating perceived stress, hardiness, and hope.ResultsUsing structural equation modelling, perceived stress was found to be negatively related to hope. Additionally, there was a positive relationship between hardiness and hope. The findings indicate that hardiness is a buffer in the link between perceived stress and hope for women with breast cancer.ConclusionsThese findings demonstrate the importance of hardiness in reducing the effects of perceived stress on hope and have clinical implications for health professionals.
Quantitative reconstruction of salinity history by otolith oxygen stable isotopes: An example of a euryhaline fish Lateolabrax japonicus
Authors: Hsieh Yu , Shiao Jen‐Chieh , Lin Saul‐wood , Iizuka Yoshiyuki 
Published: May 2019

RationaleOtolith strontium:calcium (Sr:Ca) ratios have been extensively used to study fish migration across a river, estuary and ocean at each life stage. However, otolith Sr:Ca ratios only explain partial variations in salinity and quantitative reconstruction of salinity history of fishes remains a challenge. Using a euryhaline fish Lateolabrax japonicus as an example, this study demonstrated an isotopic method of quantitatively reconstructing the salinity histories and habitat uses of the fish.MethodsOtolith oxygen stable isotopic ratios (δ18Ooto values) were measured using a mass spectrometer for subsamples sequentially milled from the otolith core to the edge, and otolith Sr:Ca ratios were measured by an electron probe microanalyzer for the comparison. The mean water temperature within the studied area in the time period of each milled subsample was estimated from the Copernicus database. Based on an isotopic fractionation equation, each δ18Ooto value and water temperature pair determined the water δ18O value, which was then converted into salinity using published linear equations or an equation that was newly generated for this study.ResultsIndividual fish clearly revealed different preferences in habitat use. The retrospectively reconstructed salinity history indicated that most L. japonicus inhabit and can spawn in seawater as well as in brackish estuaries. Few fish lived in freshwater during the young stage based on the analysis of δ18Ooto profiles; however, otolith Sr:Ca ratios can only reveal freshwater residence and cannot distinguish residence in brackish water or seawater.ConclusionsThis study demonstrated that otolith temporal microstructure and δ18Ooto values are well‐suited approaches for quantitative reconstruction of salinity histories of the fish. This method can improve the understanding of the habitat uses of other fishes inhabiting diverse habitats among the rivers, estuaries and oceans.
Study of Precursor‐Inks Designed for High‐Quality Cu2ZnSnS4 Films for Low‐Cost PV Application
Authors: Trifiletti Vanira , Mostoni Silvia , Butrichi Fabio , Acciarri Maurizio , Binetti Simona , Scotti. Roberto 
Published: May 2019

AbstractKesterite compound Cu2ZnSnS4 is the most promising next leader in the chalcogenide thin films technology as it is based on earth‐abundant elements. In this work, kesterite thin films were prepared with a wet chemistry method by using a DMSO solution containing thiourea and acetylacetone, without further addition of vapour sulfur compounds to obtain the Cu2ZnSnS4 phase. The composition and stability of the molecular precursor‐ink were investigated by EPR, IR and Raman spectroscopy. Acetate precursors were proved to have a primary role in creating a network in the sol‐gel transition by bridging the metals in solution, together with thiourea and DMSO coordination. The high‐quality of the thin films, obtained by spin coating deposition and thermal treatment at 500 °C, was assessed by XRD, Raman, Energy‐Dispersive spectroscopy and optical analysis, which revealed a direct band gap of 1.5 eV. Therefore, the precursor‐ink and the deposition process developed in this work are very well suitable for solar cell application.
Use of Modelica language to simulate electrified railway lines and trains
Authors: Ceraolo M. , Lutzemberger G. 
Published: May 2019

SummarySimulation of multi‐engineering systems typically requires many issues to be solved, which are to be addressed by developing appropriate modeling and simulation programming techniques. In the last years, the authors have participated in several studies in which they analyzed in detail electrified railway systems and simulated them using Modelica language. After a few years of study, despite the huge complexity of these systems, it has appeared evident that Modelica language is very well suited and able to effectively solve the typical issues they present. While specific railway system simulations have already been discussed in specific papers, whose focus was on application and actual results, in this paper, the authors show how to use Modelica language to solve specific modeling issues through suitable programming techniques. Moreover, the issues to be solved and the conceived techniques may be interpreted in a general way and to be applied also in different engineering domains. Finally, this paper briefly recalls the principal results obtained in previous specific papers, in which these techniques were fully implemented.
Hypersurfaces quasi-invariant by codimension one foliations
Authors: Pereira Jorge Vitório , Spicer Calum 
Published: May 2019

Abstract
We present a variant of the classical Darboux-Jouanolou Theorem. Our main result provides a characterization of foliations which are pull-backs of foliations on surfaces by rational maps. As an application, we provide a structure theorem for foliations on 3-folds admitting an infinite number of extremal rays.
Inheritance of resistance to Cercospora leaf spot disease of cowpea [Vigna unguiculata (L.) Walp]
Authors: Omoigui Lucky O. , Arrey Matilda O. , Kamara Alpha Y. , Danmaigona Catherine C. , Ekeruo Godspower , Timko Michael P. 
Published: May 2019

AbstractCercospora leaf spot (CLS) caused by Pseudocercospora cruenta (Sacc.) is an important disease affecting cowpea production in Nigeria. Understanding the genetic nature of CLS is an important step in developing an effective breeding strategy. This study investigated the inheritance of CLS disease in cowpea under natural epiphytotic field condition involving two CLS resistant parents (IT99K-573-1-1, IT99K216-24) and a CLS susceptible parent (UAM09-1055-6). The parental lines, F1, BC1P1, BC1P2, F2 and F3 generations were used to study the genetic nature and to detect SSR markers closely linked with the CLS resistance gene(s) using bulked segregant analysis (BSA). The result showed that F1 populations involving UAM09-1055-6 × IT99K-573-1-1 and UAM09-1055-6 × IT99K-216-24 were resistant to CLS in the 2 crosses suggesting the presence of gene dominance in the control of the disease. The observed segregating ratio of F2 populations fits the Mendalian ratio 3:1. The plants reaction to the disease in the backcross progeny test involving the resistant parent were all uniformly resistant, whereas those involving the susceptible parent segregated into ratio 1:1. The F3 generations, which segregated into ratio 1:2:1 further confirmed that resistance was controlled by a single dominant gene in the crosses studied. Heritability estimates varied from 81 to 97%. BSA showed that SSR marker code named RB24 of lima bean and validated on F2 population discriminated between resistance and susceptibility to CLS. Hence RB24 could be a useful marker for marker-assisted selection in CLS resistance breeding in cowpea.
The endpoint epidemic of IoT – just a bad dream?
Authors: Giese Sascha 
Published: May 2019

Over the past decade we've heard a lot of concern from security vendors about the rise of the Internet of Things (IoT) and the growth of smart devices. On a daily basis, technology professionals are struggling to keep their organisations secure, even though the endpoint epidemic that has kept experts up at night hasn't fully manifested itself in the way we feared. The growth of the Internet of Things (IoT) has been a key theme of the past few years but the endpoint epidemic that has kept experts up at night hasn't fully manifested itself in the way we feared. Yet despite its slow burn, IoT should remain a top priority for today's cyber security professionals. A self-healing, automated network can detect threats, keep data from being compromised and reduce downtime. Infrastructure teams within today's digital businesses need to operate at a speed that leaves little room for manual updates and almost certainly requires automation, suggests Sascha Giese at SolarWinds.
Decrease in vancomycin-resistantEnterococcuscolonization associated with a reduction in carbapenem use as empiric therapy for febrile neutropenia in patients with acute leukemia
Authors: Ford Clyde D. , Coombs Jana , Stofer Michaela Gazdik , Lopansri Bert K. , Webb Brandon J. , Ostronoff Fabiana , Asch Julie , Hoda Daanish 
Published: May 2019

AbstractObjective:To compare the effects of empiric carbapenems versus cycling cefepime and piperacillin/tazobactam on the rates of vancomycin-resistantEnterococcus(VRE) colonization, bloodstream infections, and outcomes of patients admitted with acute leukemia.Design:Retrospective clinical study with VRE molecular strain typing and gastrointestinal microbiome comparison.Setting:A regional referral center for acute leukemia.Patients:342 consecutive patients admitted with newly diagnosed acute leukemia.Methods:In September 2015, we changed our empiric antibiotic of choice for neutropenic fever from a carbapenem to the cycling regimen. We studied 214 consecutive patients during the carbapenem period and 128 during the cycling period. Surveillance for VRE stool colonization was conducted weekly. Representative stool samples were analyzed for VRE MLST types and changes in the composition and diversity of the fecal microbiota.Results:The change in empiric antibiotics was associated with a significant decrease in VRE colonization (hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.27–0.66), a switch in the dominant VRE MLST types on the unit, and some modifications in the gastrointestinal microbiome. There were no differences in total gram-positive or gram-negative BSIs. During the carbapenem period, we observed higher absolute numbers ofCandidaspp and fewer ESBL BSIs, but these did not reach statistical significance. Patients during the carbapenem period had longer lengths of stay and durations of severe neutropenia and 10% higher hospital cost.Conclusions:Carbapenem-sparing empiric antibiotic regimens may have advantages related to VRE ecology, gastrointestinal dysbiosis, duration of neutropenia, cost and length of stay.
Syn-kinematic palaeogeographic evolution of the West European Platform: correlation with Alpine plate collision and foreland deformation
Authors: Sissingh W. 
Published: May 2019

AbstractSequence stratigraphic correlations indicate that intermittent changes of the kinematic far-field stress-field regimes, and the associated geodynamic re-organisations at the plate-tectonic contacts of the African, Apulian, Iberian and European plates, affected the Tertiary palaeogeographic evolution of the West European Platform through a combination of intra-plate tectonics and fluctuations of relative sea level. A temporal sequence of first-order stages in structural, palaeotopographic and palaeohydrographic development of the platform can be distinguished from the Paleocene onwards. These formative stages are closely linked to major plate-boundary events involving the development of the Pyrenean and Alpine orogens, and can be traced throughout the West European Platform.
Impact of levamisole in co-administration with benznidazole on experimental Chagas disease
Authors: Rocha Simões-Silva Marianne , Brandão Peres Raiza , Britto Constança , Machado Cascabulho Cynthia , de Melo Oliveira Gabriel , Nefertiti da Gama Aline , França da Silva Cristiane , Lima da Costa Karine , Finamore Araújo Paula , Diego de Souza Campos Jerônimo , Meuser Batista Marcos , Cristina Demarque Kelly , da Cruz Moreira Otacílio , de Nazaré Correia Soeiro Maria 
Published: May 2019

AbstractLevamisole (Lms) is an anthelminthic drug with immunomodulatory activity. Chagas disease (CD) is caused byTrypanosoma cruziand there is very low access to the drugs available, benznidazole (Bz) and nifurtimox, both far from ideal. In a drug-repurposing strategy to test potential activity as antiparasitic and immunomodulatory agent for CD, Lms was assayed on acuteT. cruzimurine infection, alone and in co-administration with Bz. During protocol standardization, 100 and 10 mpk of Bz given for five consecutive days resulted in parasitaemia suppression and 100% animal survival only with the highest dose. Flow cytometry showed that both optimal (100 mpk) and suboptimal (10 mpk) doses of Bz equally decreased the plasma levels of cytokines commonly elevated in this acute infection model. Lms alone (10–0.5 mpk) did not decrease parasitaemia nor mortality rates. Co-administration was investigated using the suboptimal dose of Bz and different doses of Lms. While Bz 10 mpk did not alter parasitaemia, the combo partially reduced it but only slightly promoted animal survival. This effect could be related to Th1-response modulation since interleukin-6 and interferon-γwere higher after treatment with the combo.