bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comfort Need of Hospitalised Patients With Covid‐19 During Isolation Precaution: A Qualitative Study
Authors: Edison Chiyar , Waluyo Agung , Yona Sri , Eryando Tris 
Published: November 2024

ABSTRACTAimThis study aimed to explore the experiences of hospitalised patients with Covid‐19 in terms of the meeting of their comfort needs and the source of discomfort during isolation precautions.DesignQualitative descriptive phenomenological approach was applied in this study.MethodsThere were 16 hospitalised patients with Covid‐19 and 11 nurses who were thoroughly interviewed. Content analysis was conducted to examine the data of the interviews and then managed using Atlas ti‐9 software.ResultsFive central themes were identified that describe the comfort needs and the source of discomfort, as follows: (1) nursing professionalism; (2) physical discomfort; (3) psychological responses; (4) poor sleep quality; and (5) spiritual adaptations.Public ContributionThe study promoted further explanation about comfort need in patients with Covid‐19 in isolation room. This study also highlighted that nursing care played a pivotal part in assisting patients to reach their highest comfort level.
PhD‐DNP Collaboration: An Integrative Review of Scholarly Partnerships in Nursing
Authors: Garcia Theresa J. , Bai Jinbing , Shen Natalie , Smith Lenora , Koszalinski Rebecca S. 
Published: November 2024

ABSTRACTNurses holding terminal degrees, Doctor of Philosophy (PhD), Doctor of Nursing Science (DNS), and Doctor of Nursing Practice (DNP), fulfill different roles in nursing. The continued growth of nursing science and practice is dependent on alliances between these nurses that produce state‐of‐the‐art knowledge and support the translation of evidence to practice. This integrative review described characteristics of scholarly collaborations between nurses holding a research‐focused degree, the PhD, and those holding a practice‐focused degree, the DNP. Five major nursing, medicine, and education databases were searched for peer‐reviewed, original articles addressing or describing the characteristics of PhD‐DNP scholarly collaborations, published through March 2023. In total, 15 articles met the inclusion criteria, and an integrative synthesis was conducted using constant comparison and thematic analysis. Findings included one overarching theme, Role Clarification, as well as four subthemes that emerged across the sample, describing key characteristics of collaborative PhD‐DNP scholarship: (1) Mutual understanding and appreciation of strengths; (2) Strategic project planning and team building; (3) Clear organizational/administrative directives and guidance; and (4) Shared goals for the nursing profession. Articles describing the collaboration between nurses holding doctoral degrees are limited and provide primarily lower‐level research evidence and evidence‐based practice outcomes. Despite efforts to foster scholarly collaborations among nurses holding terminal degrees, more research is needed to clarify individual roles, offer tangible strategies for collaboration, and measure outcomes of collaboration benefitting healthcare systems, patient outcomes, and the nursing profession. This integrative review involved only the review of the extant literature.
Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™‐1 and ‐2)
Authors: Wharton Sean , le Roux Carel W. , Kosiborod Mikhail N. , Platz Elke , Brueckmann Martina , Jastreboff Ania M. , Ajaz Hussain Samina , Pedersen Sue D. , Borowska Luiza , Unseld Anna , Kloer Isabel M. , Kaplan Lee M. ,   the SYNCHRONIZE‐1 and ‐2 trial committees and investigators
Published: November 2024

AbstractObjectiveThe objective of this study was to describe the rationale and design of two multinational phase 3 clinical trials of survodutide, an investigational glucagon and glucagon‐like peptide‐1 receptor dual agonist for the treatment of obesity with or without type 2 diabetes (T2D; SYNCHRONIZE‐1 and ‐2).MethodsIn these ongoing double‐blind trials, participants were randomized to once‐weekly subcutaneous injections of survodutide or placebo added to lifestyle modification. Survodutide doses are uptitrated to 3.6 or 6.0 mg, and dose flexibility is permitted. Participants (n = 726) in SYNCHRONIZE‐1 (NCT06066515) have a baseline BMI ≥ 30 kg/m2 or ≥27 kg/m2 with at least one obesity‐related complication but without T2D; participants (n = 755) in SYNCHRONIZE‐2 (NCT06066528) have a baseline BMI ≥ 27 kg/m2 and T2D. The primary endpoints are percentage change in body weight and proportion of participants achieving ≥5% body weight reduction from baseline to week 76. Secondary endpoints include change in systolic blood pressure and measures of glycemia. A SYNCHRONIZE‐1 substudy is evaluating changes in body composition and liver fat content using magnetic resonance imaging.ConclusionsThese trials are designed to provide robust evaluation of the efficacy, safety, and tolerability of survodutide for the treatment of obesity in the presence or absence of T2D.
L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds
Authors: Imam Ibrahim A. , Al Adawi Shatha , Liu Xiaoqi , Ellingson Sally , Brainson Christine F. , Moseley Hunter N. B. , Zinner Ralph , Zhang Shulin , Shao Qing 
Published: November 2024

ABSTRACTAcquired resistance to first‐line treatments in various cancers both promotes cancer recurrence as well as limits effective treatment. This is true for epidermal growth factor receptor (EGFR) mutations, for which secondary EGFR mutations are one of the principal mechanisms conferring resistance to the covalent inhibitor osimertinib. Thus, it is very important to develop a deeper understanding of the secondary mutational resistance mechanisms associated with EGFR mutations arising in tumors treated with osimertinib to expedite the development of innovative therapeutic drugs to overcome acquired resistance. This work uses all‐atom molecular dynamics (MD) simulations to investigate the conformational variation of two reported EGFR mutants (L858R/L718Q and L858R/L792H) that resist osimertinib. The wild‐type EGFR kinase domain and the L858R mutant are used as the reference. Our MD simulation results revealed that both the L718Q and L792H secondary mutations induce additional hydrogen bonds between the residues in the active pocket and the residues with the water molecules. These additional hydrogen bonds reduce the exposure area of C797, the covalent binding target of osimertinib. The additional hydrogen bonds also influence the binding affinity of the EGFR kinase domain by altering the secondary structure and flexibility of the amino acid residues in the domain. Our work highlights how the two reported mutations may alter both residue‐residue and residue‐solvent hydrogen bonds, affecting protein binding properties, which could be helpful for future drug discovery.
Identification of cytokine release syndrome and indicators of severity in retrospective databases among patients receiving immunotherapy
Authors: Huntington Scott F. , Lin Dee , Lafeuille Marie‐Hélène , Thompson‐Leduc Philippe , Shah Aditi , Kim Nina , Hester Laura , Tardif‐Samson Anabelle , Moore Bronwyn , Fowler Jessica , Marshall Alexander , Zhang Xinke , Gifkins Dina , Wu Bingcao 
Published: November 2024

AbstractCytokine release syndrome (CRS) can occur following cancer immunotherapies, but is most often mild and of limited duration. International Classification of Diseases (ICD)‐10 codes allowing identification of CRS were introduced in 2020 but may be underutilized. We evaluated the performance of a published claims‐based algorithm to detect CRS (any grade) and high‐grade CRS (HG, grades 2‐5), as well as identified indicators of HG CRS in retrospective data. Adults with low‐grade and HG CRS during an encounter coinciding with administrations of blinatumomab or chimeric antigen receptor‐T therapy were identified in three types of retrospective databases (hospital chargemaster data, electronic health records, and administrative claims). The algorithm's sensitivity in detecting any CRS and HG CRS was reported. A least absolute shrinkage and selection operator (LASSO) regression model was developed to identify indicators of HG CRS. Performance of the model was evaluated using area under the curve (AUC). The sensitivity of the algorithm to detect any grade CRS ranged between 77%–100% and between 8%–80% for HG CRS, depending on the type of database. The LASSO model identified hypotension, positive pressure (including mechanical ventilation), tocilizumab, and vasopressors as indicators of HG CRS. AUC varied between 60% and 75%. The algorithm accurately detected any grade CRS for over three‐quarters of instances, but was not as reliable for HG CRS. Results varied based on database attributes. Hypotension, vasopressors, positive pressure, and tocilizumab were associated with HG CRS and may be methodologically helpful signals of CRS severity in retrospective data.
The miR‐31b targets arylsulfatase B to regulate the ovarian development of Bactrocera dorsalis
Authors: Yu Shan‐Shan , Zhang Qiang , Zheng Li‐Yuan , Xie Qian‐Ping , Wang Jin‐Jun , Dou Wei 
Published: November 2024

AbstractBACKGROUNDReproduction is the basis of insect population growth and evolution, and encompasses ovarian development, reproductive behavior, and fecundity. Bactrocera dorsalis is a globally significant agricultural pest that is subject to quarantine, with mated females that can lay over 3000 eggs. The post‐transcriptional regulation of ovarian development remains unclear. Here, miR‐31b is shown to be involved in regulating Bactrocera dorsalis ovarian development.RESULTSCRISPR/Cas9 was used to generate miR‐31b loss‐of‐function mutations in Bactrocera dorsalis. The removal of miR‐31b resulted in severely impaired ovarian development in adults, with phenotypes that included dramatically reduced egg production and hatching rates. The relationship between miR‐31b and its target gene arylsulfatase B (ARSB) was subsequently identified using the methods of bioinformatics, transcriptomic sequencing, quantitative polymerase chain reaction (qPCR), RNA pull‐down and dual‐luciferase reporter assay. Finally, miR‐31b was confirmed to bind the target gene arylsulfatase B to affect metabolism and thereby further hindered ovarian development of Bactrocera dorsalis.CONCLUSIONOverall, these results provide new insights into molecular mechanisms at the post‐transcriptional level in regulating ovarian development and insect reproduction, consequently providing potential targets to control arthropod pests through the reproductive strategy. © 2024 Society of Chemical Industry.
Natural Pitch‐Derived Carbon Networks Induced Lattice Strain Engineering in Nickel‐Based Heterostructures Enables Efficient Anodes for Sodium‐Ion Batteries
Authors: Jiang Shu , Jiang Zhao , Li Chenglin , Khanam Zeba , Wang Feng , Ouyang Ting , Balogun M.‐Sadeeq 
Published: November 2024

AbstractThe development of high‐performance sodium‐ion batteries (SIBs) relies on enhancing the electrochemical properties of the electrodes, particularly the transition metal compounds (TMCs) through effective carbon coatings. Herein, a straightforward approach using polymerized natural pitch‐derived carbon (PNPC) via step‐growth polymerization regulates the lattice strain in Ni3S2‐NiO heterostructures (NSNO) on nickel foam (NF). This method replaces the complex multistep carbon coatings with a cost‐effective liquid‐phase application of PNPC, followed by pyrolysis to create PNPC@NSNO/NF. Comparative analysis shows that PNPC effectively modulates lattice strain, achieving 3.50% tensile strain compared to 5.60% for non‐polymerized carbon. The optimized PNPC@NSNO/NF electrode exhibits exceptional high areal capacity of 2.72 mAh cm−2@1 mA cm−2, impressive rate capability, and 97.28% capacity retention after 200 cycles. The enhanced contact area and electrical conductivity provided by the PNPC improve charge transfer kinetics and overall performance. Theoretical analyses confirm that the PNPC@NSNO/NF electrode with 3.50% lattice strain lowers the Na⁺ diffusion barrier, enhances charge transfer, and improves charge distribution, boosting the electrode performance. This work establishes a straightforward method for synthesizing lattice‐strained SIB anodes, highlighting its potential for advancing SIB technology.
Design of Self‐Standing Chiral Covalent‐Organic Framework Nanochannel Membrane for Enantioselective Sensing
Authors: Zheng Chen‐Yan , Qian Hai‐Long , Yang Cheng , Yan Xiu‐Ping 
Published: November 2024

AbstractNanochannel membranes are promising materials for enantioselective sensing. However, it is difficult to make a compromise between the selectivity and permeability in traditional nanochannel membranes. Therefore, new types of nanochannel membranes with high enantioselectivity and excellent permeability should be explored for chiral analysis. Here, asymmetric catalysis strategy is reported for interfacial polymerization synthesis of chiral covalent‐organic framework (cCOF) nanochannel membrane for enantioselective sensing. Chiral phenylethylamine (S/R‐PEA) and 2,4,6‐triformylphloroglucinol (TP) are used to prepare chiral TP monomer. 4,4′,4″‐triaminotriphenylamine (TAPA) is then condensed with chiral TP to obtain cCOF nanochannel membrane via a C═N Schiff‐base reaction. The molar ratio of TP to S/R‐PEA is adjusted so that S/R‐PEA is bound to the aldehyde only or both the aldehyde and hydroxyl groups on TP to obtain chiral‐induced COF (cCOF‐1) or both chiral‐induced and modified COF (cCOF‐2) nanochannel membrane, respectively. The prepared cCOF‐2 nanochannel membrane showed two times more selectivity for limonene enantiomers than cCOF‐1 nanochannel membrane. Furthermore, cCOF‐2 nanochannel platform exhibited excellent sensing performance for other chiral molecules such as limonene, propanediol, methylbutyric acid, ibuprofen, and naproxen (limits of detection of 19–42 ng L−1, enantiomer excess of 63.6–86.3%). This work provides a promising way to develop cCOF‐based nanochannel enantioselective sensor.
Evolutionary decision‐making behaviour among the government, leading enterprises and farmers: Based on the improvement of phaeozem quality in Northeast China
Authors: Teng Yun , Sun Yue , Cheng Qi 
Published: November 2024

AbstractThe improvement of phaeozem quality in Northeast China is crucial to China's food security. This study incorporated government, leading enterprises and farmers into an evolutionary game model to explore the ideal state among the government, leading enterprises and farmers with the improvement of the phaeozem quality in Northeast China, thereby contributing to food security. The study includes the government, leading enterprises and farmers in an evolutionary game model to explore game relationship and evolution paths of decision‐making among the three stakeholders, and obtains the conditions for the three parties to evolve to the ideal state by analysing and combining with the actual data. The evolutionary process of the decision‐making behaviour of the three stakeholders to an ideal state is affected by many factors, and the value ranges of the different factors have different impacts on the convergence speed of the three stakeholders to an ideal state; when certain conditions are met, the decision‐making behaviours of the three stakeholders can evolve to an ideal state, which aims to provide beneficial suggestions for the government to supervise the quality of phaeozem, leading enterprises to control green agricultural products and farmers to apply organic fertilizer.
A Novel Cortex Phellodendri Chinensis–Based Carbon Dots Platform for Remarkable Analgesia for Clinical Pain Management
Authors: Peng Huimin , Zeng Xingxing , Li Songbai , Wang Xin 
Published: November 2024

ABSTRACTIn this study, we explored the eco‐friendly synthesis of photoluminescent CCDs employing a direct one‐step pyrolysis process, utilizing natural Cortex Phellodendri Chinensis as the precursor material and studied their analgesic effect in mice. The synthesized carbon dots underwent comprehensive characterization through a range of spectroscopic and microscopic techniques. These included UV‐Vis, FTIR, fluorescence spectroscopy and HR‐TEM, DLS instruments. HR‐TEM results exhibited the presence of homogenous spherical‐shaped C‐dots of about 3.3 nm without aggregates. Furthermore, the prepared CCDs were studied for their in vivo analgesic effect in mice by performing tail‐immersion, hot plate and acetic acid writhing tests. Also, an MTT assay was performed to assess the in vitro cytotoxicity of CCDs against L929 cells. In vitro cytotoxicity studies revealed that L929 cells exhibited higher cell viability when treated with prepared CCDs. The cellular uptake studies revealed the phase contrast images of MG‐63 cells at wavelength 488 nm clearly depicted the aggregation of green, fluorescent CCDs within the cells while leaving nuclei unobscured. In addition, to the best of our understanding, the results presented in this paper showed that CCDs exhibited an important analgesic effect and enhanced anti‐nociceptive activity, which may be due to stimulation of the opioidergic system. Consequently, CCDs appear to be a viable analgesic alternative for traditional analgesic candidates in pain management.
The remarkable Jersey hailstorm of 1–2 November 2023: description and comparison with other cool season, dual‐hazard storms
Authors: Wells Henry M. , Webb Jonathan D. C. , Holley Dan , Clark Matthew R. , Hillier John 
Published: November 2024

AbstractAround midnight on 1/2 November 2023, Jersey (Channel Islands) was impacted by a supercell storm which produced both a tornado, rated T6/IF3, and very large hail. This article presents details of that remarkable hailstorm and places it into context by investigating severe hail events during the October–March cool season in the UK and Crown Dependencies of Jersey, Guernsey, and the Isle of Man. The storm is compared to previous ‘dual‐hazard’ events during the cool season, where both a tornado and severe hail were produced.
Optimization of nanoscale heat transport analysis of ternary hybrid nanofluid over three‐dimensional wedge geometry in magnetized environment
Authors: Shah Syed Zahir Hussain , Wahab Hafiz Abdul , Khan Shahzeb , Alderremy Aisha Abdullah , Mahmoud Emad Elian 
Published: November 2024

AbstractExponential space‐based heat source with shear‐thinning/thickening behavior offers innovative insights into the optimization of thermal transport process in complex systems, such as in the cooling of microelectronics, energy storage technologies, and biomedical devices, where accurate thermal control is critical. This study explores the investigation of an exponential space‐based heat source with effects of shear thinning/thickening behavior of a ternary infinite shear rate viscosity‐dependent Carreau water‐based nanofluid [Cu, Fe3O4, SiO2] over a three‐dimensional wedge in a magnetized environment. The interaction between heat transport and magnetic fields is explored through the behavior of the ternary nanofluid by classifying the both shear‐thinning and shear‐thickening effects. The incorporation of physical assumptions in the model gives the set of partial differential equations (PDEs) and similarity transformations are launched to convert them into ordinary differential equations (ODEs). Furthermore, bvp4c scheme is used to fetch the numerical solution. Temperature profile is increasing with exponential‐based source heat parameter due to a reduction in the rate of heat absorption by the fluid. Ternary nanofluids exhibit the highest rate of temperature increment due to the effects of multiple nanoparticles as compared to hybrid or single‐nanoparticle nanofluids. Rate of velocity decrement in ternary nanofluids compared to bi‐hybrid nanofluids and single‐particle nanofluids.
Introduction
Authors: Sangster Joan , Keating James , Kristjánsdóttir Ragnheiður 
Published: November 2024

Abstract
This book explores disenfranchisement and other voting barriers before and after the introduction of so-called universal suffrage. Focusing on economic voting restrictions, implemented through constitutional provisions, laws, state policies, and ad-hoc practices, we explore the many disqualifications barring people from voting in self-governing and aspiring liberal democracies, including poor relief dependency, lack of property or wealth, bankruptcy, tax debt, and low income. The notions of economic independence underpinning these exclusions built and reinforced unequal social structures, especially in terms of class, gender, race, age, civil status, and education. Examining suffrage from an economic perspective prompts new questions about democracy and political citizenship as contested concepts. This approach illuminates the histories of democratic practices, state formation, welfare states, the economic entanglements of political citizenship, gender and racial hierarchies, and the unique circumstances of colonial and settler-colonial democracies. After exploring the influence of Enlightenment ideas on liberal democratic notions of political citizenship, this introduction highlights themes that unite the chapters. These are centred around four concerns: poor relief; different experiences of suffrage at the national, provincial, and local levels; voter exclusion through policy and vernacular political practices; and colonialism.
The effects of professional expertise on perceptions of treatment need in patients with class II division 1 malocclusion: a comparison between orthodontists, general dentists, and lay people in Germany
Authors: Bühling Sarah , Neidhardt Stefanie , Sayahpour Babak , Eslami Sara , Plein Nicolas , Kopp Stefan 
Published: November 2024

Abstract
Purpose
This study aimed to compare the perception of practitioners with varying levels of expertise and laypeople regarding the orthodontic treatment need and facial harmony in patients with increased anterior overjet.

Methods
Three groups of observers (orthodontists, general dentists, and laypeople, in total n = 48) were asked to rate on images—using a 10-point visual analog scale (VAS)—the facial harmony and treatment need of a sample of 8 patients with class II division 1 malocclusion and overjets of 2, 4, 6, and 8 mm.

Results
Statistically significant differences were observed between the three groups of observers regarding patients with an overjet of 4 mm and above (p < 0.001). Treatment need was perceived at an overjet of 4 mm by orthodontists and 6 mm by general dentists, whereas laypeople did not perceive a need for treatment in any of the groups (p < 0.001). Regarding perception of facial harmony, orthodontists had the lowest threshold (4 mm overjet), while dentists followed at a greater overjet of 6 mm or more (p < 0.001). A statistically significant correlation between the noticed facial harmony and the perceived orthodontic treatment need was found in all observers (p < 0.001).

Conclusion
The perceived orthodontic treatment need for class II division 1 malocclusion increased with increasing professional expertise.