bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasmall Iron Fluoride Nanoparticles Embedded in Graphitized Porous Carbon Derived from Fe‐Based Metal Organic Frameworks as High‐Performance Cathode Materials for Li Batteries
Authors: Zhang Qi , Liu Nan‐Nan , Sun Cheng‐Zhi , Fan Li‐Shuang , Zhang Nai‐Qing , Sun Ke‐Ning 
Published: March 2019

AbstractIron‐based metal organic framework (MOF) MIL‐53 is used as a precursor and self‐template to synthesize a 3D porous carbon/FeF3 ⋅ 0.33 H2O composite in situ. We find that the organic ligands in iron‐containing MOFs can convert into highly graphitized carbon with the catalysis of central Fe atoms. The FeF3 ⋅ 0.33 H2O nanoparticles formed after fluorination and dehydration are surrounded by highly graphitized carbon. In the composite, the graphitized 3D porous carbon can provide passageways for electron transport and ultrasmall FeF3 ⋅ 0.33 H2O nanoparticles facilitate the diffusion of Li ions. The composite shows excellent performance for the Li storage. A capacity of 86 mAh g−1 can be reached at an ultra‐high rate of 20 C. Even after 300 charge−discharge cycles at 5 C, the capacity remains at 113 mAh g−1.
Highly Sensitive Method to Isolate Photocurrent Signals from Large Background Redox Currents on Protein‐Modified Electrodes
Authors: Jun Daniel , Beatty J. Thomas , Bizzotto Dan 
Published: March 2019

AbstractThe high quantum efficiency in converting light energy into a charge‐separated state is a major advantage in using photosynthetic proteins in biophotovoltaic applications. Photocurrents are typically measured at open circuit potential (OCP), where the electrochemical redox or faradaic currents are minimized. However, at potentials far from the OCP, the photocurrents produced by the proteins may be impossible to measure against the large background current, owing to electrochemical redox reactions of charge‐transfer mediators and/or sacrificial electron donors. Demonstrated here is a highly sensitive method using a sinusoidal‐modulated intensity of an LED excitation light source to isolate the protein‐based photocurrent component from the total current irrespective of electrode surface coverage. Using a genetically modified photochemical reaction center from Rhodobacter sphaeroides as a proof‐of‐concept, photocurrents up to 104–105 orders of magnitude smaller than the background electrochemical redox current (due to redox reactions directly on the electrode surface) were measured at applied voltages >0.4 V from the OCP. The phase relationship between the optical excitation and photocurrent response was also measured and shown to be analytically useful.
One Stone for Three Birds‐Rhodium‐Catalyzed Highly Diastereoselective Intramolecular [4+2] Cycloaddition of Optically Active Allene‐1,3‐dienes
Authors: Han Yulin , Qin Anni , Ma Shengming 
Published: March 2019

Summary of main observation and conclusionRhCl(PPh3)3‐catalyzed [4+2] intramolecular cycloaddition of optically active axially chiral allene‐dienes afforded cis‐fused [3.4.0]‐bicyclic products with three chiral centers in good yields with an excellent chemo‐ and diastereoselectivity. A pair of enantiomers of such products was generated highly selectively from both enantiomers of starting allene‐dienes, indicating that the axial chirality dictated the absolute configurations of the three in situ generated chiral centers with a very high efficiency of chirality transfer.
Ancestral characterization of 1018 cancer cell lines highlights disparities and reveals gene expression and mutational differences
Authors: Kessler Michael D. , Bateman Nicholas W. , Conrads Thomas P. , Maxwell George L. , Dunning Hotopp Julie C. , O’Connor Timothy D. 
Published: March 2019

BackgroundAlthough cell lines are an essential resource for studying cancer biology, many are of unknown ancestral origin, and their use may not be optimal for evaluating the biology of all patient populations.MethodsAn admixture analysis was performed using genome‐wide chip data from the Catalogue of Somatic Mutations in Cancer (COSMIC) Cell Lines Project to calculate genetic ancestry estimates for 1018 cancer cell lines. After stratifying the analyses by tissue and histology types, linear models were used to evaluate the influence of ancestry on gene expression and somatic mutation frequency.ResultsFor the 701 cell lines with unreported ancestry, 215 were of East Asian origin, 30 were of African or African American origin, and 453 were of European origin. Notable imbalances were observed in ancestral representation across tissue type, with the majority of analyzed tissue types having few cell lines of African American ancestral origin, and with Hispanic and South Asian ancestry being almost entirely absent across all cell lines. In evaluating gene expression across these cell lines, expression levels of the genes neurobeachin line 1 (NBEAL1), solute carrier family 6 member 19 (SLC6A19), HEAT repeat containing 6 (HEATR6), and epithelial cell transforming 2 like (ECT2L) were associated with ancestry. Significant differences were also observed in the proportions of somatic mutation types across cell lines with varying ancestral proportions.ConclusionsBy estimating genetic ancestry for 1018 cancer cell lines, the authors have produced a resource that cancer researchers can use to ensure that their cell lines are ancestrally representative of the populations they intend to affect. Furthermore, the novel ancestry‐specific signal identified underscores the importance of ancestral awareness when studying cancer.
A Thermodynamic Model of Auto‐regulated Protein Assembly by a Supramolecular Scaffold
Authors: Rennie Martin L. , Crowley Peter B. 
Published: March 2019

AbstractLigand‐mediated regulation of protein assembly occurs frequently in different cellular contexts. Auto‐regulated assembly, where a ligand acts as its own competitive inhibitor, provides a mechanism for exquisite control of assembly. Unlike simple protein‐ligand systems a quantification of the binding thermodynamics is not straightforward. Here, we characterize the interactions of a recently identified model system in which the oligomerization of cytochrome c is controlled by sulfonato‐calix[8]arene, an anionic supramolecular scaffold. Isothermal titration calorimetry and thermodynamic modelling, in combination with Bayesian fitting, were used to quantify the ligand binding and assembly equilibria for this system. The approach and variations of this model may prove useful for the analysis of auto‐regulated protein assembly in general.
Laser Spectroscopy and Lifetime Measurements of the S1 State of Tetracyanoquinodimethane (TCNQ) in a Cold Gas‐Phase Free‐Jet
Authors: Chaki Nobumasa , Muramatsu Satoru , Iida Yuji , Kenjo Seiya , Inokuchi Yoshiya , Iimori Toshifumi , Ebata Takayuki 
Published: March 2019

AbstractThe S1 electronic state of 7,7,8,8‐Tetracyanoquinodimethane (TCNQ) has been investigated by laser induced fluorescence (LIF), dispersed fluorescence (DF) spectroscopy, and lifetime measurements under jet‐cooled conditions in the gas‐phase. The LIF spectrum showed a weak origin band at 412.13 nm (24262 cm−1) with prominent progression and combination bands involving vibrations of 327, 1098, and 2430 cm−1. In addition, very strong bands appeared at ∼363.6 nm (3300 cm−1 above the origin). Both the LIF and DF spectra indicate considerable geometric change in the S1 state. The fluorescence lifetime of S1 at zero‐point level was obtained to be 220 ns. This lifetime is 40 times longer than the radiative lifetime estimated from the S1−S0 oscillator strength. Furthermore, the lifetimes of the vibronic bands exhibited drastic energy dependence, indicating a strong mixing with the triplet (T1) or intramolecular charge‐transfer (CT) state. This study is thought to disclose intrinsic nature of TCNQ, which has been well known as a component of organic semiconductors and a versatile p‐type dopant.
Rat Left Ventricular Cardiomyocytes Characterization in the Process of Postinfarction Myocardial Remodeling
Authors: Baidyuk Ekaterina V. , Sakuta Galina A. , Vorobev Mikhail L. , Stepanov Andrei V. , Karpov Andrei A. , Rogoza Olga V. , Kudryavtsev Boris N. 
Published: March 2019

AbstractIschemic lesions of the heart, including myocardial infarction, are the most common pathologies of human cardiovascular system. Despite all the research and achievements of medicine in this field, the mortality from this disease remains heavy. Therefore, studying of processes occurring in the myocardium in the early and late postinfarction periods remains important. Rat left ventricular cardiomyocyte (CMC) ploidy, hypertrophy, hyperplasia, and ultrastructure were investigated in 2, 6, and 26 weeks after experimental myocardial infarction, caused by permanent ligation of left coronary artery. Cytofluorimetric study of CMC ploidy revealed no difference between normal, sham‐operated, and infarcted animals for all the tested stages. However, interference microscopy indicated significant changes in cells size. CMC dry mass of infarcted rats in 2 weeks after surgery was 1.5 times lower than in control and sham operated groups. Electron microscopy analysis of CMC revealed disruption of sarcomere structure. However, in 6 weeks after surgery CMC dry mass was 1.6 times higher than in control. In 26 weeks after myocardial infarction CMC dry mass exceeded control only in peri‐infarction zone. Cell counting showed that the number of left ventricular CMC, reduced as a result of myocardial infarction, was not restored during myocardial remodeling. © 2019 International Society for Advancement of Cytometry
An application of paired quasilinearization on double‐diffusive convection flow over a cone embedded in a porous medium in the presence of nanoparticles
Authors: Otegbeye Olumuyiwa , Motsa Sandile S. , Ansari Md. Sharifuddin 
Published: March 2019

AbstractMixed convection flow of a nanofluid near a vertical cone embedded in a a porous medium with Soret and Dufour effects is exercised. The bearing of a porous medium is recounted by the Darcy model. The partial differential equations, modeling the concerned problem, is nondimensionalised by implementing compatible transformations, which results in a similar form. A new paired spectral quasilinearization method is adopted to get the accurate numerical solution. Convergence and accuracy of the solution is elaborated by analyzing the norm of residual and solution errors. Alteration of velocity, temperature, nanoparticle and solute concentration profiles due to flow controlling parameters, namely, Brownian motion, thermophoresis, Soret, Dufour, Lewis number, and buoyancy ratio is outlined by reproducing the obtained numerical solution in graphs and tables. Analysis reveals that the flow profiles are greatly influenced by the physical parameters under investigation.
Relationships between microbial communities and groundwater chemistry in two pristine confined groundwater aquifers in central China
Authors: Ma Jie , Liu Hui , Tong Lei , Wang Yan , Chen Rong , Liu Shan , Zhao Lei , Li Zhimin , Cai Liegang 
Published: March 2019

AbstractThis study explores linkages between the microbial composition and hydrochemical variables of pristine groundwater to identify active redox conditions and processes. Two confined aquifers underlying the city of Qianjiang in the Jianghan Plain in China were selected for this study, having different recharge sources and strong hydrochemical gradients. Typical methods for establishing redox processes according to threshold concentration criteria for geochemical parameters suggest iron or sulphate reduction processes. High‐throughput 16S rRNA sequencing was used to obtain diversity and taxonomic information on microbial communities. Instead of revealing iron‐ and sulphate‐reducing bacteria, salt‐ and alkali‐tolerant bacteria, such as the phylum Firmicutes and the class Gammaproteobacteria, and in particular, the family Bacillaceae, were dominant in the downstream groundwater of the first aquifer that had high ion concentrations caused by the dissolution of calcite and dolomite; meanwhile, the heterotrophic microaerophilic families Comamonadaceae and Rhodocyclaceae prevailed in the upstream groundwater of the first aquifer. Sulphate‐reducing bacteria were extremely abundant in the upstream groundwater of the second aquifer, as the SO42− concentration was especially high. Methanogens and methanotrophs were predominant in the downstream groundwater of the second aquifer even though the concentration of SO42− was much higher than 0.5 mg L−1. The microbial communities, together with the geochemical parameters, indicated that the upstream region of the first aquifer was suboxic, that Fe(III) and Mn(IV) reductions were not the main redox processes in the downstream groundwater of the first aquifer with high Fe and Mn concentrations, and that the redox processes in the upstream and downstream regions of the second confined aquifer were SO42− reduction and methanogenesis, respectively. This study expands understanding of the linkages between microbial communities and hydrogeochemistry in pristine groundwaters and provides more evidence for identifying active redox conditions and processes.
Association of a genetic variant in ATP‐binding cassette sub‐family B member 1 gene with poor prognosis in patients with squamous cell carcinoma of the esophagus
Authors: Rastgar‐Moghadam Azam , Mehramiz Mehrane , Shahidsales Soodabeh , Entezari Malihe , Hassanian Seyed Mahdi , Talebian Sahar , Nourbakhsh Mahnaz , Ferns Gordon A. , Avan Amir 
Published: March 2019

ABSTRACTEsophageal cancer is a common cause of death from cancer in men and the eighth most prevalent cancer globally. The morbidity and mortality rates are four times higher in men than in women. Genetic factors are among the susceptibility factors for squamous cell carcinoma of the esophagus. The rs2032582 polymorphism is a triallelic missense variant of the ABCB1 gene, that has been reported to be associated with several cancers. Here we have explored the association of the ABCB1 rs2032582 polymorphism with esophageal squamous cell carcinoma (ESCC) for the first time in a total of 251 subjects, with and without ESCC. Data from patient's record were obtained from the Mashhad University of Medical Sciences, and were used to recruit ESCC patients into the study. A total of 89 ESCC patients and 162 healthy controls were included. DNAs were extracted and genotyped using a TaqMan real‐time PCR‐based method. Caplan Meier method was applied to analyze patients overall survival, and progression‐free survival and log‐rank were used in order to compare the results. Logistic regression was used to calculate the association between risk of ESCC and different genotypes. Our data showed that patients with ESCC had a higher frequency of a T/A (TT/TA/AA) genotype for rs2032592 than individuals with GG‐genotype. There were no associations between BMI and genotypic frequencies. Furthermore patients with TT/TA/AA genotypes had a poorer disease‐free survival (P = 0.016) in comparison with GG genotype. We found a significant association of the ABCB1 rs2032582 polymorphism with prognosis, although further studies in a larger and multicenter setting are needed to value these findings. © 2019 IUBMB Life, 71(9):1252–1258, 2019
Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy
Authors: Anselmo Alessandro , Prezioso Carla , Saccà Filippo Antonino , Di Lella Federica Maria , Palmieri Giampiero , Tisone Giuseppe , Pietropaolo Valeria , Ciotti Marco 
Published: March 2019

AbstractBKPyV replication is a risk factor for the development of polyomavirus‐associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor‐1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b‐1.
Determinants of Quality of Life in Patients With Intestinal Failure Receiving Long‐Term Parenteral Nutrition Using the SF‐36 Questionnaire: A German Single‐Center Prospective Observational Study
Authors: Blüthner Elisabeth , Bednarsch Jan , Stockmann Martin , Karber Mirjam , Pevny Sophie , Maasberg Sebastian , Gerlach Undine A. , Pascher Andreas , Wiedenmann Bertram , Pratschke Johann , Pape Ulrich‐Frank 
Published: March 2019

AbstractBackgroundParenteral nutrition (PN) is a life‐sustaining therapy for patients with chronic intestinal failure (IF) but inevitably has an impact on patients’ quality of life (QoL). The purpose of this study was to examine multiple aspects of QoL by utilizing the standardized Short Form 36 (SF‐36) health survey.MethodsBetween 2014 and 2017, a total of 90 adult patients with IF who were receiving PN were prospectively enrolled in an observational study. All subjects underwent nutrition status assessment, liver assessment, blood tests, and QoL assessment based on the SF‐36. Univariate and multivariable analyses were performed to identify determinants of 8 domains and 2 summary scales of the SF‐36.ResultsAnalysis of the SF‐36 questionnaire data showed that QoL was significantly worse compared with the general German population across all categories. Multivariable analysis revealed that bioelectrical impedance analysis of phase angle (1/10 categories), stoma/fistula (4/10 categories), oral intake (4/10 categories), infusions per week (1/10 categories), duration of PN (1/10 categories), citrulline (4/10 categories), and hemoglobin levels (1/10 categories) are independent risk factors affecting QoL.ConclusionThis study uses the largest cohort of IF patients assessed by the standardized SF‐36 questionnaire to comprehensively analyze QoL. Presence of oral intake, presence of ostomy, and citrulline levels were independently correlated with 4 of 10 categories of the SF‐36. These results indicate that to improve QoL for IF patients, clinical care should focus on addressing the social and emotional value of oral intake, educational interventions, early stoma closure, and application of new targeted therapies.
Early Postnatal Changes of Bone Turnover Biomarkers in Very Low‐Birth‐Weight Neonates—The Effect of Two Parenteral Lipid Emulsions with Different Polyunsaturated Fatty Acid Content: A Randomized Double‐Blind Study
Authors: Papandreou Panos , Agakidis Charalampos , Scouroliakou Maria , Karagiozoglou‐Lampoudi Thomai , Kaliora Adriana , Kalogeropoulos Nick , Siahanidou Tania 
Published: March 2019

AbstractBackgroundω‐3 polyunsaturated fatty acids (n‐3 PUFAs) are reported to have beneficial effect on bone mineral density. This study aimed to evaluate early changes of bone turnover biomarkers in very low‐birth‐weight (VLBW) neonates and the effect of 2 parenteral lipid emulsions (PLEs) with different PUFA composition.MethodsThis is a randomized double‐blind study with parallel design. VLBW neonates (n = 66) receiving parenteral nutrition (PN)>70% of daily energy requirements for >14 days were assigned into 2 groups that were prescribed soybean oil–based (n = 35) and n‐3–enriched PLE (n = 31), respectively. Osteoprotegerin (OPG), soluble receptor activator of nuclear factor‐kB ligand (sRANKL), osteocalcin (OC), interleukin‐6 (enzyme‐linked immunoblot assay kits), Ca, and P plasma levels were assessed before PLE implementation (T1) and on day 20 of life (T2).ResultsIn the total population, sRANKL and OC significantly increased, whereas OPG and the OPG/sRANKL ratio decreased from T1 to T2. Within each group, T1‐to‐T2 changes of OC were significant in both groups, whereas those of OPG/sRANKL were significant only in the soybean‐based group. Multiple regressions showed an independent effect of group allocation on OPG change. Significant associations were observed between PN duration and sRANKL change (negatively), n‐6/n‐3 and OC changes (positively), and OPG and sRANKL changes (positively).ConclusionsA high bone‐turnover rate in VLBW neonates with predominance of bone resorption is confirmed. The lower rate of OPG/sRANKL reduction in the n‐3–enriched PLE group indicates that n‐3 PUFA–enriched PLEs may help to attenuate early bone loss in VLBW neonates.
Biological detoxification of Monascus purpureus pigments by heat‐treated Saccharomyces cerevisiae
Authors: Davoudi Moghadam Hediyeh , Shahidi Fakhri , Tabatabaei Yazdi Farideh , Sarabi Jamab Mahboobe , Eshaghi Zarrin 
Published: March 2019

AbstractBACKGROUNDToday, there is an increasing concern about the consumption of synthetic colorants in food because of their possible health hazards. Monascus purpureus has attracted a great deal of attention as it produces various coloured pigments with high chemical stability, but it also produces citrinin, a secondary toxic metabolite, along with the pigments. This study aims to investigate the amount of pigment and citrinin reduction by different treatments with Saccharomyces cerevisiae such as heat treatment and suspension concentration.RESULTSThe results indicated that the ability of S. cerevisiae regarding citrinin adsorption increased with increase of temperature and yeast concentration. The maximum extent of citrinin adsorption was related to heat treatment at 121 °C and a yeast concentration of 105 cells mL−1, for which citrinin reduced from 4.43 mg L−1 in control to 0.1 mg L−1. Heat treatment of 103 cells mL−1 suspension of S. cerevisiae cells at 50 °C, with 0.56 mg L−1 citrinin remaining in the medium, showed the lowest ability for citrinin binding. The optimum absorbance of all red, orange and yellow pigments was observed for the heat treatment at 50 °C and yeast concentrations of 103 and 104 cells mL−1 which was greater than that for the control.CONCLUSIONSWe can conclude from this study that heat treatment with S. cerevisiae can be a useful way to reduce citrinin to below the standard limits. © 2019 Society of Chemical Industry
Cytoreduction and hyperthermic intraperitoneal chemotherapy in metastatic colorectal cancer
Authors: Eng Oliver S. , Turaga Kiran K. 
Published: March 2019

AbstractAs the management of metastatic colorectal cancer (CRC) has evolved over the past decades, optimal management of CRC with peritoneal metastases remains controversial, especially about cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. In this review, we highlight the current data on this challenging disease process, as well as comment on its limitations.
Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials
Authors: Advani Shailesh , Kopetz Scott 
Published: March 2019

AbstractMetastatic colorectal cancer (mCRC) continues to show poor outcomes, with many patients exhausting effective standard‐of‐care therapy. To explore the current landscape of clinical trials for mCRC, we reviewed over 600 clinical trials that are currently ongoing for mCRC patients. Immunotherapeutic agents form approximately 39% (includes monoclonal antibodies, viruses, vaccines, and immunomodulators) of all agents and targeted therapy forms 45% (tyrosine kinase inhibitors, epigenetic modulators, and others) of all agents being investigated for mCRC.