bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental participation in newborn care in the view of health care providers in Uganda: a qualitative study
Authors: Wanduru Phillip , Hanson Claudia , Kwesiga Doris , Kakooza-Mwesige Angelina , Mölsted Alvesson Helle , Waiswa Peter 
Published: October 2024

Abstract
Background
Evidence suggests that family-centered care for sick newborns, where parents are co-caregivers in newborn care units, can result in increased breastfeeding frequency, higher weight gain, earlier discharge, and reduced parental anxiety. This study explored healthcare providers' perceptions and experiences of parental participation in care for sick newborns in the newborn care units in two high-volume maternity units in Uganda, with the aim of informing interventions that promote family-centered care for newborns.

Methods
An exploratory qualitative study was conducted between August and December 2023. Sixteen in-depth interviews were held at a regional and general hospital in the rural eastern region of Uganda. The interviews were audio-recorded and then transcribed, followed by a reflexive thematic analysis approach to generate themes.

Findings
We identified four key themes: (1) creating order to ensure the safety of newborns in the newborn care unit; (2) parental participation as a tool for overcoming workload in the Newborn care unit; (3) redirecting parental involvement to focus on medically endorsed newborn care practices; and (4) stress management targeting mothers to ensure newborn survival.

Conclusion
Healthcare providers encourage parents to participate in caring for their newborns in the newborn care units, mainly to reduce their workload. However, our study highlights the imbalanced nature of parental involvement, where HCPs control the tasks parents can or cannot perform, essentially deploying them as "assistants" rather than equal partners, contrary to the ideals of family-centered care. Transforming the current "healthcare provider-centered" model of caring for sick newborns to one that is family-centered will require training providers on the benefits of family-centered care and developing guidelines for its structured implementation within a resource-limited setting.
Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1st reported case of the world with a proposed ‘updated diagnostic criteria’
Authors: Dwivedi Dhara , Prabhakar Nitin , Yuwanati Monal , Aswal Gunjan S. , Rawat Renu 
Published: October 2024

Abstract
Background
POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the 1st case of Primordial odontogenic tumor (POT) from Sub-Saharan Africa with unique clinicopathological features; also, this is the first case to report POT’s existence as a Hybrid Odontogenic lesion (HOL), with a pertinent review of the literature.

Case presentation
This was a 17-year-old patient who presented with slow-growing, painless posterior mandibular swelling. The imaging revealed a well-defined, unilocular, expansile, lytic lesion with internal calcific foci surrounding an impacted #36, indicating a calcifying odontogenic cyst. The incisional biopsy revealed the presence of POT. The tumor was excised along with the involved tooth.

Conclusion
POT is predominantly a non-aggressive and mostly affects the pediatric population. Hence, clinicians must be updated on all the aspects of this tumor to diagnose it appropriately and avoid any undue over—or under-treatment.
Digital rehabilitation care planning for people with chronic diseases (RehaPro-SERVE): study protocol for a German multicentre randomised controlled trial
Authors: Buch Kristina , van der Wardt Veronika , Seifart Ulf , Haasenritter Jörg , Maulbecker-Armstrong Catharina , Seferi Pellumbesha , Becker Annette 
Published: October 2024

Abstract
Background
Chronic diseases are a significant and growing problem of our time. They impair the ability to work and increase the risk of early retirement. To support the return to work, rehabilitation services can be applied for in Germany. Currently, the application system for rehabilitation allows only a limited degree of individualisation of the treatment and is associated with a lack of multidisciplinary communication. To facilitate rehabilitation care planning, we developed a complex intervention. A digital, platform-based case management approach (intervention) will ensure multidisciplinary communication and the tailored selection of medical treatments and/or non-medical support measures. The overall objective is to assess the effectiveness of the intervention compared to treatment as usual (control condition). The German Federal Ministry of Labour and Social Affairs (BMAS) funds the RehaPro-SERVE study (grant number: 661R0053K1).

Methods
This is the protocol for an investigator-initiated, pragmatic, multicentre, randomised and controlled two-arm parallel-group superiority trial with embedded qualitative process evaluation. The study will be conducted in Hesse state, Germany. N = 59 primary care physicians will be recruited and tasked with the recruitment of six eligible patients each. Eligibility criteria: age 40–60; minimum of 4-week work disability due to musculoskeletal, oncologic or psychological conditions or the post-COVID-19 syndrome within the last 6 months; at high risk for early retirement. In total, n = 352 patients will be randomised with a 1:1 allocation to intervention or control group and stratified by primary care practice using permuted blocks. The primary outcome is the number of days of sick leave during a 12-month period after the assumed completion of treatments (t1 to t2). Secondary outcomes include the number of days of sick leave (self-report), work ability, and health-related quality of life, as well as data from the qualitative process evaluation.

Discussion
The results of the study will inform the design of future care services and provide valuable information on multidisciplinary case management in the context of rehabilitation care planning. The results of the qualitative process evaluation will further contribute to the understanding of facilitating and hindering factors.

Trial registration
DRKS-German Clinical Trials Register, DRKS0 00242 07. Registered on 22 March 2021.
Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia
Authors: Loewenstein Daniël S. L. , van Grinsven Max , de Pont Cécile , Dautzenberg Paul L. J. , van Strien Astrid M. , Henssen Dylan 
Published: October 2024

Abstract
Purpose
The loss of olfactory function is known to occur in patients suffering from (behavioral variant) frontotemporal dementia ((bv)FTD) and Alzheimer’s disease (AD), although different pathophysiological mechanisms underpin this clinical symptom in both disorders. This study assessed whether brain metabolism of the olfactory circuit as assessed by positron emission tomography (PET) imaging with 2-[fluorine-18]fluoro-2-deoxy-d-glucose ([18F]-FDG) can distinguish these entities in different subsets of patients.

Methods
Patients presenting with cognitive decline were included from a prospectively kept database: (1) bvFTD patients, (2) AD patients and (3) patients with logopenic primary progressive aphasia (PPA). Metabolic rates were calculated for different regions of the olfactory circuit for each subgroup and compared with a cohort of subjects with normal brain metabolism. Additionally, in patients with a logopenic PPA pattern on PET-imaging, statistical parametric mapping (SPM) analysis was performed.

Results
The metabolism of subdivisions of the olfactory circuit as assessed by [18F]-FDG PET brain imaging to bvFTD and AD from control subjects resulted in sensitivity/specificity rates of 95/87.5% and 80/83.3%, respectively. A sensitivity/specificity rate of 100/87.5% was achieved when used to differentiate AD from bvFTD. In patients with the PPA pattern on imaging, the underlying cause (either FTD or AD) could be determined with a sensitivity/specificity rate of 88/82%. SPM analysis concurred that different regions of the olfactory circuit were affected in patients suffering from AD PPA or bvFTD PPA.

Conclusion
Metabolic dysfunction in the olfactory circuit is different in various neurodegenerative disorders. Further investigation of the correlations between the cerebral metabolism and the mechanisms which drive olfactory dysfunction is needed.
The Hungarian fossil record of the Pliocene pig Sus arvernensis (Suidae, Mammalia)
Authors: Iannucci Alessio , Pazonyi Piroska , Sebe Krisztina 
Published: October 2024

AbstractSus arvernensis is a Pliocene species that occupies a key position in the evolution of suids (Suidae, Artiodactyla, Mammalia) in Eurasia, and besides, it is considered important for biochronological correlations and paleoecological inferences. However, our knowledge on S. arvernensis is largely based on fossil remains from southwestern Europe. Here, we present a revision of the Hungarian fossil record of S. arvernensis. Up to now, the species was known from only two localities of Hungary, Gödöllő (central Hungary) and Süttő (northwest Hungary), and the latter occurrence has even been questioned. After the comparison with other relevant samples of S. arvernensis, of the Early Pleistocene S. strozzii, and of the extant wild boar S. scrofa (motivated by previous attributions and the chronology of the localities), the presence of S. arvernensis from Gödöllő and Süttő is confirmed, and more material of the species is described from Beremend (southern Hungary) and Kisláng (western Hungary). Collectively, the results of the revision carried out herein reveal a relatively widespread distribution of S. arvernensis in Hungary, hence providing an important link from the eastern to western European fossil record of the species. The specimens from Gödöllő and Süttő are slightly larger than the other material of S. arvernensis from France and Italy included in the biometric comparison, although the paucity of the material precludes to evaluate whether these differences are significant and to relate them to a chronological and/or geographical context. The occurrence of S. arvernensis in the Hungarian localities considered in this work is a biochronological indication of an age older than at least 2.6 Ma, since the species is not recorded after the Pliocene–Pleistocene transition. This in agreement with the age estimates available so far for some of the localities or provides new insights. At Süttő, in particular, the identification of S. arvernensis reinforces the view that travertine deposition started already in the Pliocene.
A prediction model of PTSD in the Israeli population in the aftermath of october 7th, 2023, terrorist attack and the Israel–Hamas war
Authors: Katsoty Dana , Greidinger Michal , Neria Yuval , Segev Aviv , Lurie Ido 
Published: October 2024

Abstract
Background
On October 7th, 2023, a mass terror attack was launched by Hamas militants, which was followed by the Israel-Hamas war. These events constitute a nationwide trauma with major ramifications for public mental health. This article presents an evidence-based model for the prediction of the prevalence of posttraumatic stress disorder (PTSD) related to the terrorist attack and the war.
Main body: The creation of the model consisted of several steps. Firstly, the Israeli population was divided into six groups based on the intensity, context, and type of traumatic exposure (direct exposure to terror, close proximity to terror, soldiers in combat and support units, intense exposure to rocket attacks, moderate exposure to rocket attacks, and indirectly affected communities), and the population size of each group was assessed using official national databases. Secondly, an estimation of the expected prevalence of PTSD in each of the exposure groups was based on a review of the relevant literature. A random-effects meta-analysis of the prevalence rates was conducted separately per each exposure group. Finally, the predicted number of PTSD causalities in the population was calculated by multiplying the group size and the PTSD prevalence estimation. Based on population size and estimated PTSD prevalence within each exposure category, the model predicts that approximately 5.3% (N = 519,923) of the Israeli population (95% confidence interval, 1.64–9%), may develop PTSD as a result of the terrorist attack and the war.

Conclusions
The predicted number of individuals with PTSD following mass trauma is expected to be considerable. The presented model can assist policymakers, clinicians, and researchers in preparing and devising adequate interventions for the mental health needs of large populations. Moreover, this model can be applied in other instances of mass-trauma exposure.
Application and new findings of scRNA-seq and ST-seq in prostate cancer
Authors: Li Zhuang , Li Zhengnan , Luo Yuanyuan , Chen Weiming , Fang Yinyi , Xiong Yuliang , Zhang Qinyi , Yuan Dongbo , Yan Bo , Zhu Jianguo 
Published: October 2024

AbstractProstate cancer is a malignant tumor of the male urological system with the highest incidence rate in the world, which seriously threatens the life and health of middle-aged and elderly men. The progression of prostate cancer involves the interaction between tumor cells and tumor microenvironment. Understanding the mechanisms of prostate cancer pathogenesis and disease progression is important to guide diagnosis and therapy. The emergence of single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing (ST-seq) technologies has brought breakthroughs in the study of prostate cancer. It makes up for the defects of traditional techniques such as fluorescence-activated cell sorting that are difficult to elucidate cell-specific gene expression. This review summarized the heterogeneity and functional changes of prostate cancer and tumor microenvironment revealed by scRNA-seq and ST-seq, aims to provide a reference for the optimal diagnosis and treatment of prostate cancer.
Development of craquelure patterns in paintings on canvas
Authors: Bury Marcin , Bratasz Łukasz 
Published: October 2024

Abstract
Canvas paintings are layered structures composed of canvas support sized with animal glue, a preparatory layer of the ground, and paint and varnish layers on the top. Preventing or limiting humidity-induced stresses in these structures requires an understanding of the relevant processes and risks. A three-dimensional model of a canvas painting was used to analyse stresses and crack development in the two-layer structure comprised of a glue-sized canvas on a wooden stretcher with a layer of stiff chalk-glue ground representing a pictorial layer in historic canvas paintings. The model was subjected to a large relative humidity fall which induced shrinkage of the glue-sized canvas. The modelling revealed that when a stretcher with flexible wooden bars is considered, high tensile stresses arise in the ground layer at the corners of the painting, and cracks are formed in these areas in the direction perpendicular to the painting’s diagonal. Ratios of critical distances between cracks to the ground layer thickness for which stresses in the midpoints between the cracks dropped to below the level inducing fracture in the material were estimated for various magnitudes of the relative humidity drop and thicknesses of the ground layer. Increasing ground layer thickness limits the hygric response of the sized canvas and makes the paintings less vulnerable to humidity variations. The ratio of stress along the diagonal calculated for painting with one crack to the solution without cracks was described by the double Lorentz function. A simple procedure of calculating stress variations along the diagonal—using the function—on a sequential addition of cracks was developed. Cracks in central parts of canvas painting were found to be induced by permanent cumulative drying shrinkage of the oil-based paints and grounds due to the evolution of the molecular composition of the oil binder. The outcome of the modelling indicated that the risk of cracking of the pictorial layers in canvas paintings due to drops in ambient relative humidity was small.
Quadricuspid aortic valve with complete heart block: a double whammy
Authors: Dhillon Mukesh , Sharma Aditi 
Published: October 2024

Abstract
Background
Developmental abnormalities of aortic valve cusps are relatively common with the bicuspid valve being the most frequently encountered congenital heart disease. However, the quadricuspid aortic valve (QAV) is an exceedingly rare abnormality.

Case presentation
We report a case involving a young, otherwise healthy male who presented with non-exertional syncope and was subsequently diagnosed with complete heart block (CHB). Further evaluation revealed the coexistence of a rare quadricuspid aortic valve and CHB. This combination, in the absence of surgery or infective endocarditis, has only been reported once before in the literature.The patient underwent successful permanent pacemaker implantation and continues to be monitored for aortic regurgitation.

Conclusions
The coexistence of a QAV with CHB, in the absence of infective endocarditis or aortic valve surgery, is extremely rare and necessitates careful evaluation and follow-up.
Associations Between Balance Measures and Risk of Fractures in 70-Year-Old Individuals
Authors: Nordström Peter , Ballin Marcel , Nordström Anna 
Published: October 2024

Abstract

Context
There are uncertainties regarding to what extent poor vision and distracting tasks reduce balance and are associated with fracture risk.

Objective
This work aimed to investigate the associations between body sway assessed under different visual and multitasking conditions and later risk of fractures in older adults.

Methods
This cohort study was conducted in Umeå municipality, Sweden. A total of 5437 community-dwelling 70-year-old individuals participated in a population-based health examination. Body sway at baseline was measured using a Wii balance board in the lateral and anterior-posterior direction during 3 different tests, including with eyes open, dual-tasking, and eyes closed. Fractures during follow-up were ascertained using nationwide registers.

Results
During a mean (range) follow-up of 4.8 (0.0-10.6) years, 348 women (12.3%) and 149 men (5.7%) sustained a fracture. In women, both anterior-posterior sway velocity (hazard ratio [HR], 1.05; 95% CI, 1.01-1.08, per mm/s increase) and variation in sway velocity (HR, 1.05; 95% CI, 1.01-1.09, per SD increase) during dual-tasking testing were associated with higher risk of fracture after adjustment for covariates. During testing with eyes closed, all measures of lateral sway were associated with the risk of fracture (P &lt; .01 for all). In men, variation in lateral (HR, 1.03; 95% CI, 1.00-1.07 per SD increase) and anterior-posterior sway velocity (HR 1.05; 95% CI, 1.01-1.10 per SD increase) during dual-tasking testing were associated with higher risk of fracture.

Conclusion
Higher body sway velocity and larger variation in sway velocity were associated with a higher risk of fractures both in 70-year-old men and women, especially under more challenging testing conditions.
Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy
Authors: Hawkins Kate , Watt Meg , Gillotin Sébastien , Hanspal Maya , Helley Martin , Richardson Jill , Corbett Nicola , Brownlees Janet 
Published: October 2024

ABSTRACT
AMBRA1 has critical roles in autophagy, mitophagy, cell cycle regulation, neurogenesis and apoptosis. Dysregulation of these processes are hallmarks of various neurodegenerative diseases and therefore AMBRA1 represents a potential therapeutic target. The flexibility of its intrinsically disordered regions allows AMBRA1 to undergo conformational changes and thus to perform its function as an adaptor protein for various different complexes. Understanding the relevance of these multiple protein–protein interactions will allow us to gain information about which to target pharmacologically. To compare potential AMBRA1 activation strategies, we have designed and validated several previously described mutant constructs in addition to characterising their effects on proliferation, apoptosis, autophagy and mitophagy in SHSY5Y cells. AMBRA1TAT, which is a mutant form of AMBRA1 that cannot interact with DLC1 at the microtubules, produced the most promising results. Overexpression of this mutant protected cells against apoptosis and induced autophagy/mitophagy in SHSY5Y cells in addition to enhancing the switch from quiescence to proliferation in mouse neural stem cells. Future studies should focus on designing compounds that inhibit the protein–protein interaction between AMBRA1/DLC1 and thus have potential to be used as a drug strategy for neurodegeneration.
Security enhancement for NOMA-PON with 2D cellular automata and Turing pattern cascading scramble aided fixed-point extended logistic chaotic encryption
Authors: Wang Yun , Zhang Qi , Xin Xiangjun , Sun Meng , Gao Ran , Yao Haipeng , Tian Feng , Tian Qinghua , Wang Yongjun , Wang Fu , Zhou Sitong , Li Zuolin , Li Zhipei 
Published: October 2024

The non-orthogonal multiple access-passive optical network (NOMA-PON) is facing the dual security threats of primary user interference and unauthorized third-party user eavesdropping, so efficient data security enhancement techniques are crucial. To solve these problems, we propose a fixed-point extended (FE)-logistic chaotic mapping to reduce the computational complexity while employing a two-dimensional (2D) cellular automata (CA) and Turing pattern (TP) cascading scramble (CA-TPCS) encryption algorithm to further improve the sensitivity of the NOMA-PON system. The CA-TPCS consists of 2D-CA dynamic bit encryption and Turing symbol substitution (TSS). By using FE chaos to construct 2D-CA and adopting index sort to extract the TSS matrix, dynamic diffusion of bits and scrambling of a 2D symbol matrix are achieved. To ensure the key privacy, we employ a dual key mechanism, and uplink data is introduced as the private key. To verify the feasibility of the proposed method, a simulation validation is built on a 17.6 Gb/s power division multiplexing-orthogonal frequency division multiplexing (PDM-OFDM) NOMA-PON system transmitted over 25 km standard single mode fiber (SSMF). The results show that the proposed scheme has no effect on the optimal power allocation rate (PAR) values and the values are all 3. Meanwhile, the receiver sensitivity gains of 0.2 and 0.3 dB are obtained for high-power and low-power users after encryption. The ciphertext has good diffusion and statistical properties, and the key space is flexibly controlled by the FE precision f, the length l of the transmitted bit, and the size T of the TP, with the value of 22f+l+T×T. The results show that the proposed scheme is not only very compatible with PDM technology but also can realize the dual defense of internal aggression and external aggression. It has a good application prospect in the future NOMA-PON.