bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Residues within GABAAReceptor α Subunits That Mediate Specific Assembly with Receptor β Subunits
Authors: Taylor Pamela M. , Connolly Christopher N. , Kittler Josef T. , Gorrie George H. , Hosie Alistair , Smart Trevor G. , Moss Stephen J. 
Published: April 2018

GABAAreceptors can be constructed from a range of differing subunit isoforms: α, β, γ, δ, and ε. Expression studies have revealed that production of GABA-gated channels is achieved after coexpression of α and β subunits. The expression of a γ subunit isoform is essential to confer benzodiazepine sensitivity on the expressed receptor. However, how the specificity of subunit interactions is controlled during receptor assembly remains unknown. Here we demonstrate that residues 58–67 within α subunit isoforms are important in the assembly of receptors comprised of αβ and αβγ subunits. Deletion of these residues from the α1 or α6 subunits results in retention of either α subunit isoform in the endoplasmic reticulum on coexpression with the β3, or β3 and γ2 subunits. Immunoprecipitation revealed that residues 58–67 mediated oligomerization of the α1 and β3 subunits, but were without affect on the production of α/γ complexes. Within this domain, glutamine 67 was of central importance in mediating the production of functional α1β3 receptors. Mutation of this residue resulted in a drastic decrease in the cell surface expression of α1β3 receptors and the resulting expression of β3 homomers. Sucrose density gradient centrifugation revealed that this residue was important for the production of a 9S α1β3 complex representing functional GABAAreceptors.Therefore, our studies detail residues that specify GABAAreceptor αβ subunit interactions. This domain, which is conserved in all α subunit isoforms, will therefore play a critical role in the assembly of GABAAreceptors composed of αβ and αβγ subunits.
Improving Anaphylaxis Care: The Impact of a Clinical Pathway
Authors: Lee Juhee , Rodio Bonnie , Lavelle Jane , Lewis Megan Ott , English Rachel , Hadley Sarah , Molnar Jennifer , Jacobstein Cynthia , Cianferoni Antonella , Spergel Jonathan , Zielinski Lisa , Tsarouhas Nicholas , Brown-Whitehorn Terri 
Published: April 2018

BACKGROUND:
Recommended durations of observation after anaphylaxis have been widely variable, with many ranging from 4 to 24 hours. Prolonged durations often prompt admission for ongoing observation.

METHODS:
In a multidisciplinary quality improvement initiative, we revised our emergency department (ED) anaphylaxis clinical pathway. Our primary aim was to safely decrease the recommended length of observation from 8 to 4 hours and thereby decrease unnecessary hospitalizations. Secondary aims included provider education on anaphylaxis diagnostic criteria, emphasizing epinephrine as first-line therapy, and implementing a practice of discharging ED patients with an epinephrine autoinjector in hand. The study period consisted of the 18 months before pathway revision (baseline) and the 18 months after revision.

RESULTS:
The overall admission rate decreased from 58.2% (106 of 182) in the baseline period to 25.3% (65 of 257) after pathway revision (P &lt; .0001). There was no significant difference in the percentage of patients returning to the ED within 72 hours, and there were no adverse outcomes or deaths throughout the study period. After pathway revision, the median time to first epinephrine administration for the most critical patients was 10 minutes, and 85.4% (164 of 192) of patients were discharged with an epinephrine autoinjector in hand.

CONCLUSIONS:
By revising an anaphylaxis clinical pathway, we were able to streamline the care of patients with anaphylaxis presenting to a busy pediatric ED, without any compromise in safety. Most notably, decreasing the recommended length of observation from 8 to 4 hours resulted in a near 60% reduction in the average rate of admission.
Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats
Authors: Totou NL , Moura SS , Coelho DB , Oliveira EC , Becker LK , Lima WG 
Published: March 2018

Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and were trained for 8 weeks under similar intensities (60 min/day). Arterial pressure (AP) and heart rate (HR) were recorded. The renal function was evaluated through urinary volume at each week of training; sodium and potassium excretions, plasma and urinary osmolarities, glomerular filtration rate (GFR), levels of proteinuria, and renal damage were determined. SE and RE rats presented reduced mean AP, systolic blood pressure, and HR in comparison with S group. SE and RE rats showed higher urine osmolarity compared with S. SE rats showed higher free water clearance (P < 0.01), lower urinary density (P < 0.0001), and increased weekly urine volume (P < 0.05) in comparison with RE and S groups. GFR was increased in both SE and RE rats. The proteinuria of SE (7.0 ± 0.8 mg/24 h) rats was decreased at the 8th week of the PE in comparison with RE (9.6 ± 0.8 mg/24 h) and S (9.8 ± 0.5 mg/24 h) groups. The glomerulosclerosis was reduced in SE rats (P < 0.02). SE produced different response in renal function in comparison with RE, in which only swimming-trained rats had better profile for proteinuria and glomerulosclerosis.
Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital
Authors: Mohamed Bashir Abdrhman Bashir 
Published: April 2018

Background Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients.Materials and Methods A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014. 334 cases of dengue along with 101 cases of control were enrolled. Rapid immune chromatographic test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P< 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT.ConclusionThis study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies.
THE INFLUENCE OF ENTREPRENEUR ORIENTATION AND GOVERNMENT ROLE TOWARD BATIK SMES PERFORMANCE IN THE PACITAN
Authors: Sudjatno Sudjatno , Safitri Rini 
Published: March 2018

<p>This research has aim to determine the effect of entrepreneur orientation on performance of existing businesses in SMEs Batik Pacitan District and the government role as mediating variable. Questionnaire was used to collect data and this research called explanatory quantitative research. The sample is the amount of 40 respondents in the Pacitan that is work in the Batik SMEs. To analyse the data used Warp PLS. This research gives correlation evidence between entrepreneur orientation and business performance. The R square score in the amount of 0.64, that means regression model able to explain 64% the effect of government role to the entrepreneur orientation toward business performance and the 36% for the rest will be explained by other varible that exclude this research. Based on that result, the goverment should pay attention to the entrepreneur and give contribution to them for expand SMEs because it will give feedback to the government for example increase per capita income, opening job vacancy, and reduce unemployment. </p>
KUR’ÂN’DA DİNÎ ŞÜPHE
Authors: Denizer Nurullah 
Published: March 2018

İnsan, doğası gereği merak eden, sorgulayan, bir bilginin hakikatini
kabullenebilmek için ikna olması gereken ve bu konuda sürekli tatmin arayışı
içerisinde bulunan bir varlıktır. Bu durumdan dinî bilgi de istisna değildir.
İnsan vahiy ile kendisine bildirilen dinî bilgiler hususunda da sürekli bir
merak ve onların hakikatini arayış içerisinde olmuştur. Dinî bilginin fizikî
dünyaya dair yönü her devrin imkânları nispetince araştırılmış ve araştırılmaya
devam etmektedir. Dinî bilginin metafizik yönü ise fizikî imkânlarla
doğrulanabilir bir alan değildir. Dolayısıyla bu konular iman sahası içine
girmektedir. Sağlam bir imanın, içerisinde şüphe barındırmaması beklenir.
Bununla birlikte imanın bu seviyeye ulaşması sürecinde birey, inandığı konular
hakkında şüphe içerisine düşebilir. Bu durumda şüphe; bireyin imanî meselelerde
çıkmaza girmesine ve hatta imanını kaybetmesine sebep olabileceği gibi onu,
kuşku duyduğu konuları araştırmaya sevk ederek imanda tahkik seviyesine de
ulaştırabilir. Bu çalışmada öncelikle, Kur’ân-ı Kerîm’de şüphe anlamında
kullanılan kavramlar ele alınacak, Kur’ân-ı Kerîm’de hangi konularda insanların
şüpheye düştüğü değerlendirilecek ve Hz. Peygamber’in konu ile ilgili hadîs-i
şerîflerinden de yararlanılarak şüphenin iman ile olan ilişkisi, Kur’ân-ı Kerîm
ışığında ortaya konmaya çalışılacaktır.
Community Consensus: Respect Your Elders
Authors: Spady Darcy 
Published: April 2018

President's column
The value of senior professionals
As the SPE 2018 President, I set a goal to revisit the SPE strategic plan, which was last updated in 2013. A lot has changed over those 5 years, and SPE has responded to those changes. Our mission remains unchanged, and our commitment to the One SPE guiding principles (adopted in September 2001) has endured.
One of the products of the 2013 strategic plan was an impact review of the “Big Crew Change,” as the current generation of senior professionals with more than 30 years of industry experience retire and leave our ranks. The demographic representing those 55 and older was identified in the strategic plan as a vital and valuable segment of our membership, at risk of slipping away during the then-nascent oil price downturn.
While the crew change has passed, our strategic response to this potential significant loss of membership, knowledge, experience, and human resource is critical to the future of SPE and our industry. These valued members carry with them the institutional memory of our trade, the competencies and technical knowledge we seek to disseminate, and the volunteer spirit on which SPE was built. The value of retaining and engaging these senior professional members cannot be overstated, and I personally wish to recruit these venerated members to assist in achieving my goals.
I value these members as strategic thinkers, champions of community outreach, and supporters of corporate responsibility. They have so much to offer by mentoring less-experienced members as well as future SPE and industry leaders. These senior professional members can also mutually benefit from their continued engagement in our society. I believe it is imperative that SPE recognize the value these members represent by offering benefits tailored to their specific needs.
The Use of Grammar Learning Strategies by Libyan EFL Learners at Sebha University
Authors: Alsied Safia Mujtaba , Ibrahim Noura Winis , Pathan Mustafa Mubarak 
Published: March 2018

<em>For most English language learners, grammar can be a very hard subject and some students tend to use different types of strategies to learn grammar. Using learning strategies is very beneficial as they facilitate the learning process and make it more controlled, enjoyable and effective for learners. This study explores the grammar learning strategies used by Libyan EFL undergraduate students at the English Department of Sebha University and the most frequents used strategies. The study also aims to find out if there is a significant difference between the students' use of learning strategies and gender. The population of the study were 121 Libyan EFL undergraduate students who are currently in their first and second years. Data was collected through questionnaire distributed to the participants in the class. The result of the study revealed that Libyan EFL learners used different types of grammar learning strategies which included memory strategies, metacognitive strategies, socio-affective strategies and cognitive strategies which were the least frequent used ones. It was found that the most frequent used strategies were memory strategies. The findings also showed that there is no significant difference between the use of grammar learning strategies and the participants' genders.</em>
Investigation assembly state of spindle bearing based on improved maximum correlated kurtosis deconvolution and support vector machine
Authors: Zhang Yanfei , Li Xiaohu , Wang Sun’an , Sun Yanhui 
Published: March 2018

Aiming at the skew and misalignment between the inner and outer rings of the spindle bearing during the installation process, a new method for detecting the spindle bearing assembly state is proposed combined an improved maximum correlated kurtosis deconvolution (IMCKD) and support vector machine (SVM). The vibration and impulse signals induced by bearing assembly skew or dislocation are quite weak. In this paper, the collected vibration signals were preprocessed by IMCKD algorithm with optimized parameters between the normal and skewed state of the outer rings at first, which aims to deconvolve periodic impulse characteristic and enhance the periodic impulse component from a new assembly spindle vibration signal. Then, wavelet packet decomposition method was adopted to extract the characteristic energy value of different frequency bands, and the eigenvector of the assembly state of the spindle bearing was calculated. Furthermore, the support vector machine classification method is implemented to analyze the eigenvectors under different assembly states. Finally, the proposed method was verified by experimental results. The results show that the IMCKD and SVM methods can effectively detect the bearing assembly skew state of the spindle with an accuracy of more than 95 %.
Production and characterization of used cooking oil as an alternative fuel: optimization by response surface methodology
Authors: Kumar K. Vinod , Prasad V. V. S. 
Published: March 2018

The application of biodiesel in internal combustion engines are increasing at a faster rate, due to the fact that biodiesel posses more oxygen content (Approximately 12 %), which helps in the complete combustion of the fuel. On the other hand the production cost of the biodiesel is high compared to mineral diesel fuel. This may be due to the availability of raw oil and its high initial cost. To minimize the high initial cost of the biodiesel used cooking oil is one of the best solutions. In this paper an attempt was made to analyze the fatty acid compositions and other characteristics of used cooking oil. Optimization techniques like response surface methodology (RSM) was successfully used for better yield estimation with the help of advanced software Design Expert. The optimum values of the variables were: oil to methanol ratio (1:8.37), catalyst concentration (0.74 Wt%), reaction temperature (47.950 °C) and reaction time (54.58 min) at 250 rpm. The predicted response value at these optimum values was 96.15 %. To confirm these optimum values, experimentations were conducted based on the optimum values and achieve the yield of 96 %. This shows that the yield of used cooking oil methyl ester is very near to the optimum value with an error of 0.15 % which may be accepted. This showed that the model correctly explains the influence of the process variables on the production of FAME from used cooking oil (UCOME). And from the gas chromatography results there is equal distribution of saturated and unsaturated fatty acids. 14 % oxygen can be acclaimed in UCOME by elemental analysis. Unsaturated level of fatty acids are observed.
Zakres odpowiedzialności majątkowej małżonków majątkiem wspólnym a zgoda na zaciągnięcie zobowiązania przez współmałżonka
Authors: Olszewski Przemysław 
Published: April 2018

Artykuł przedstawia kwestię odpowiedzialności majątkowej małżonków majątkiem wspólnym za zobowiązania powstałe z czynności prawnych w kontekście udzielenia zgody pierwszego małżonka na zaciągnięcie zobowiązania przez drugiego. Analizie pod kątem odpowiedzialności majątkowej małżonków za zobowiązania powstałe z czynności prawnych poddany został artykuł 41 Kodeksu rodzinnego i opiekuńczego. W pracy poruszona została między innymi problematyka wyrażenia zgody małżonka na zaciągnięcie zobowiązania jako elementu determinującego zakres odpowiedzialności majątkowej małżonków pozostających w ustawowym ustroju majątkowym. Na gruncie rozważań dotyczących odpowiedzialności majątkowej małżonków niniejszy artykuł pomoże w odpowiedzi na pytanie, czy obecne regulacje dotyczące rozważanego zagadnienia są właściwe i adekwatnie odnoszą się do wagi normowanej materii mającej wpływ na funkcjonowanie rodziny, ale również na sprawność i pewność obrotu prawnego. Powyższa analiza pozwoli ustalić, czy interesy każdej ze stron są właściwie chronione przez prawo.
Endoscopic Analysis of Wave Propagation with Ag-nanoparticles in Curved Tube Having Permeable Walls
Authors: Irshad Nuzhat , Saleem Anber , Nadeem Sohail , Shahzadi Iqra 
Published: April 2018

Objective: The purpose of this article is to analyze the effects of different shaped Agnanoparticles
on peristaltic flow through curved tube with permeable walls.

Method:
In the considered endoscope the inner tube is rigid while outer tube experience a sinusoidal
wave and both tubes make an annulus. Bricks, cylinders and platelets are different shaped Agnanoparticles.
Toroidal coordinate system is used to examine the nature of Ag-nanoparticles mathematically
in the curved tube with viscous fluid. Analysis is performed with the consideration of
low Reynolds number and long wavelength approximation. Perturbation approximation is used to
solve the problem and achieve results for pressure gradient, pressure rise, axial velocity and stream
functions.

Results:
The effects of various parameters such as Grashoff's number, Darcy's number, radius of
the endoscope and amplitude ratio on flow variables have been discussed graphically. The contemporary
investigation has revealed that the temperature profile shows a decrease for larger shape factor
of Ag-nanoparticles. Pressure gradient exhibits higher results with larger Darcy's number. Also
trapped bolus tend to have bigger size for greater shape factor.

Conclusion:
Temperature profile for the nanofluid decreases with the increase in shape factor m of
nanoparticles. The trapping phenomena reveal that the size of inner bolus appears larger for platelet
nanoparticles as compared to brick and cylinder nanoparticles.
Micropropagation and conservation of Rheum webbianum collected from Zanaskar valley via tissue culture
Authors: Khan Shagoon Tabin , Kamili Azra N. , R.C. Gupta 
Published: March 2018

Rheum webbianum is one of the famous and popular medicinal plant found in Ladakh region. Rheum webbianum Royle is an important medicinal plant belonging to the family Polygonaceae. It is commonly known as ‘Himalayan Rhubarb’ in English, ‘Revandchini’ in Hindi, ‘xu mi da huang’ in Chinese, and ‘Lachhu’ or ‘Chu-rtsa’ in Ladakh. It is native to Asia-Temperate to Asia-Tropical, from China to India, Nepal and Pakistan. In India, it is found in Himachal Pradesh, Jammu and Kashmir, Uttar Pradesh. In Jammu and Kashmir, it is grown on open slopes and shrubberies. Due to overexploitation the Rheum webbianum has become endangered. so, it was conserved by the tissue culture and showed best results on different phytohormones. The plant formation was observed on combination of 6-Benzyl Amino Purine, Thidiazuron, 2, 4-Dichlorophenoxyacetic acid and Indole 3-butyric acid.
Plan de acción tutorial para evitar el plagio en materias de formación básica / Tutorial action plan to avoid plagiarism in basic training subjects
Authors: Ruiz Ledesma Elena Fabiola 
Published: April 2018

En el presente artículo se muestra el desarrollo de un Plan Tutorial que permitió identificar y proponer estrategias que ayuden a los estudiantes de una de las Unidades Académicas del Instituto Politécnico Nacional (IPN), a evitar que incurran en prácticas de plagio tanto de trabajos académicos como de la resolución de problemas y ejercicios de áreas de formación básica.El estudio se apoya en el paradigma sociocrítico pues se tuvo como finalidad el que los estudiantes reflexionaran y tomaran conciencia de lo nocivo que es el incurrir en prácticas de plagio.Se trabajó con 60 estudiantes quienes cursaban dos unidades de aprendizaje de formación básica (Cálculo Aplicado y Probabilidad y Estadística). Para la toma de decisiones en el desarrollo del plan de acción fue indispensable conocer el perfil de los estudiantes, mismo que se pudo identificar mediante la fase de diagnóstico. Se muestran algunos otros factores que intervienen en la problemática considerada, factores de tipo epistemológico, social, demográfico, didáctico, entre otros. Se emplearon instrumentos metodológicos como lo es el cuestionario y la entrevista, para recopilar información que permitió realizar un análisis cuantitativo para determinar categorías que condujeron a la realización de un análisis cualitativo, llegando a la determinación de estrategias que son sugeridas a los estudiantes como caminos que pueden seguir para dejar de realizar prácticas de plagio y formas que pueden ayudarles a mejorar su aprovechamiento académico en las asignaturas de matemáticas.
ANALISIS RESIDU KLORPIRIFOS DALAM SAYURAN KUBIS DENGAN METODE HPLC DI BEBERAPA PASAR TRADISIONAL DI SULAWESI UTARA
Authors: Saiya Abdon 
Published: April 2018

One type of pesticide that is widely used is a group of organophosphates with chlorpyrifos as the active ingredients, because it has more favorable characteristics such as easy to decompose and short persistence time. However, the use of pesticides in addition to leaving residues that can cause environmental pollution, also cause disruption to human health and inhibit trade. Therefore, it is necessary to monitor the use of pesticides through the fulfillment of the maximum residual limit (MRL) so as to ensure food safety by limiting pesticide residue levels on agricultural products. The purpose of this study was to determine the residual levels of chlorpyrifos in cabbage vegetables with previously optimized and validated HPLC methods. The sample of this research is vegetable cabbage taken from several traditional markets in North Sulawesi. Based on the results of the study, it was found that chlorpyrifos were detected in all samples analyzed, although the levels were still below the specified MRL value. The results of this study can be a consideration for consumers and relevant agencies in North Sulawesi to more frequently monitor and evaluate the existence and use of these compounds.