bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vision 2030 for the optimal approach to cancer research and care in Europe: A mission or a network of networks?
Authors: Philip Thierry , Almouzni Geneviève , Poortmans Philip 
Published: June 2018

Introduction: A mission-oriented approach to cancer care in Europe was proposed by Julio Celis and Dainius Pavalkis in 2017. The major proposed objective is to achieve long-term survival of 3 out of 4 cancer patients by 2030. Background: The authors are president or president-elect of Organization of European Cancer Institutes (OECI) EU Life or European Cancer Community Organization (ECCO). Results: The goal is laudable and ambitious. However, it can only be successful if it is coordinated with active involvement of all stakeholders and interacts with an already well-organized, recognized, and certified European Accreditation and Designation quality approach to identify and select the potential candidates to participate in such a virtual network. Conclusions: The building of a virtual European Cancer Institute based on coordinated networks should refer to unquestioned criteria using a solid and proven methodology operated by an independent arbitration body. The cancer community must share a fundamental responsibility to act collectively and in today’s era of the World Wide Web, it is time to think out of the box and consider the possibility of establishing networks of networks.
Linking migraine frequency with family history of migraine
Authors: Pelzer Nadine , Louter Mark A , van Zwet Erik W , Nyholt Dale R , Ferrari Michel D , van den Maagdenberg Arn MJM , Haan Joost , Terwindt Gisela M 
Published: June 2018

Background Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. Methods We investigated in 2829 migraine patients (14% males) whether ‘migraine frequency’ (measured as the number of migraine days per month) was related to ‘genetic load’ (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression. Results We found an association between the number of migraine days per month and family history of migraine for males ( p = 0.03), but not for females ( p = 0.97). This association was confirmed in a linear regression analysis. Also, a lower age-at-onset ( p < 0.001), having migraine with aura ( p = 0.03), and a high number of medication days ( p = 0.006) were associated with a stronger family history of migraine, whereas lifetime depression ( p = 0.13) was not. Discussion Migraine frequency, as measured by the number of migraine days per month, seems associated with a genetic predisposition only in males. A stronger family history of migraine was also associated with a lower age-at-onset, a higher number of medication days, and migraine with aura. Our findings suggest that specific clinical features of migraine seem more determined by genetic factors.
Operative Outcomes of Grade 3 Turf Toe Injuries in Competitive Football Players
Authors: Smith Kenneth , Waldrop Norman 
Published: June 2018

Background: Turf toe is a term used to describe a hyperextension injury to the first metatarsophalangeal joint. Although the vast majority of turf toe injuries can be treated successfully without operative intervention, there are instances where surgery is required to allow the athlete to return to play. Although there is a plethora of literature on turf toe injuries and nonoperative management, there are currently few reports on operative outcomes in athletes. Methods: We obtained all cases of turf toe repair according to the ICD-10 procedural code. The inclusion criteria included: age greater than 16, turf toe injury requiring operative management and at least a varsity level high school football player. The charts were reviewed for age, BMI, level of competition, injury mechanism, football position, setting of injury and playing surface. In addition, we recorded the specifics of the operative procedure, a listing of all injured structures, the implants used and the great toe range of motion at final follow-up visit. The AOFAS Hallux score and VAS was used postoperatively as our outcome measures. Our patient population included 15 patients. The average follow-up time was 27.5 months. Results: The average patient was 19.3 years old with a body mass index of 32.3. The average playing time missed was 16.5 weeks. The average dorsiflexion range of motion at the final follow-up was 42.3 degrees. At final follow-up, the average AOFAS Hallux score was 91.3. The average VAS pain score was 0.7 at rest and 0.8 with physical activity. Conclusion: Complete turf toe injuries are often debilitating and may require operative management to restore a pain-free, stable, and functional forefoot. This study represents the largest cohort of operatively treated grade 3 turf toe injuries in the literature and demonstrates that good clinical outcomes were achieved with operative repair. Level of Evidence: Level IV, case series
Focal and diffuse cervical spinal cord damage in patients with early relapsing–remitting MS: A multicentre magnetisation transfer ratio study
Authors: Combès Benoît , Kerbrat Anne , Ferré Jean Christophe , Callot Virginie , Maranzano Josefina , Badji Atef , Le Page Emmanuelle , Labauge Pierre , Ayrignac Xavier , Carra Dallière Clarisse , de Champfleur Nicolas Menjot , Pelletier Jean , Maarouf Adil , de Seze Jérôme , Collongues Nicolas , Brassat David , Durand-Dubief Françoise , Barillot Christian , Bannier Elise , Edan Gilles 
Published: June 2018

Background: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing–remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. Methods: We included 60 patients with RRMS <12  months and 34 age-matched controls at five centres. Axial T2*w, sagittal T2w, sagittal phase-sensitive inversion recovery (PSIR), 3DT1w, and axial magnetisation transfer (MT) images were acquired from C1 to C7. Lesions were manually labelled and mean MTR values computed both for the whole SC and for normal-appearing SC in different regions of interest. Results: Mean whole SC MTR was significantly lower in patients than controls (33.7 vs 34.9  pu, p  =  0.00005), even after excluding lesions (33.9  pu, p  =  0.0003). We observed a greater mean reduction in MTR for vertebral levels displaying the highest lesion loads (C2–C4). In the axial plane, we observed a greater mean MTR reduction at the SC periphery and barycentre. Conclusion: Cervical SC tissue damage measured using MTR is not restricted to macroscopic lesions in patients with early RRMS and is not homogeneously distributed.
Predicting risk of secondary progression in multiple sclerosis: A nomogram
Authors: Manouchehrinia Ali , Zhu Feng , Piani-Meier Daniela , Lange Markus , Silva Diego G , Carruthers Robert , Glaser Anna , Kingwell Elaine , Tremlett Helen , Hillert Jan 
Published: June 2018

Objectives: We aimed at designing a nomogram, a prediction tool, to predict the individual’s risk of conversion to secondary progressive multiple sclerosis (SPMS) at the time of multiple sclerosis (MS) onset. Methods: One derivation and three validation cohorts were established. The derivation cohort included 8825 relapsing-onset MS patients in Sweden. A nomogram was built based on a survival model with the best statistical fit and prediction accuracy. The nomogram was validated using data from 3967 patients in the British Columbia cohort, 176 patients in the ACROSS and 2355 patients in FREEDOMS/FREEDOMS II extension studies. Results: Sex, calendar year of birth, first-recorded Expanded Disability Status Scale (EDSS) score, age at the first EDSS and age at disease onset showed significant predictive ability to estimate the risk of SPMS conversion at 10, 15 and 20 years. The nomogram reached 84% (95% confidence intervals (CIs): 83–85) internal and 77% (95% CI: 76–78), 77% (95% CI: 70–85) and 87% (95% CI: 84–89) external accuracy. Conclusions: The SPMS nomogram represents a much-needed complementary tool designed to assist in decision-making and patient counselling in the early phase of MS. The SPMS nomogram may improve outcomes by prompting timely and more efficacious treatment for those with a worse prognosis.
Risk factors for the development of micro-vascular complications of type 2 diabetes in a single-centre cohort of patients
Authors: Teliti Marsida , Cogni Giulia , Sacchi Lucia , Dagliati Arianna , Marini Simone , Tibollo Valentina , De Cata Pasquale , Bellazzi Riccardo , Chiovato Luca 
Published: June 2018

Aims: In type 2 diabetes, we aimed at clarifying the role of glycated haemoglobin variability and other risk factors in the development of the main micro-vascular complications: peripheral neuropathy, nephropathy and retinopathy. Methods: In a single-centre cohort of 900 patients, glycated haemoglobin variability was evaluated as intra-individual standard deviation, adjusted standard deviation and coefficient of variation of serially measured glycated haemoglobin in the 2-year period before a randomly selected index visit. We devised four models considering different aspects of glycated haemoglobin evolution. Multivariate stepwise logistic regression analysis was performed including the following covariates at the index visit: age, disease duration, body mass index, total cholesterol, high-density lipoprotein cholesterol, triglycerides, sex, smoking habit, hypertension, dyslipidemia, treatment with anti-diabetic drugs, occurrence of macro-vascular events and the presence of another micro-vascular complication. Results: Males with high mean glycated haemoglobin, long duration of diabetes, presence of macro-vascular events and retinopathy emerged at higher risk for peripheral neuropathy. Development of nephropathy was independently associated with higher glycated haemoglobin variability, older age, male sex, current smoking status, presence of retinopathy, of peripheral neuropathy and of hypertension. Higher mean glycated haemoglobin, younger age, longer duration of diabetes, reduced estimated glomerular filtration rate and the presence of peripheral neuropathy were significantly associated with increased incidence of retinopathy. Conclusion: Glycated haemoglobin variability was associated with increased incidence of nephropathy, while mean glycated haemoglobin emerged as independent risk factor for the development of retinopathy and peripheral neuropathy. The presence of macro-vascular events was positively correlated with peripheral neuropathy. Finally, the occurrence of another micro-vascular complication was found to be a stronger risk factor for developing another micro-vascular complication than the mean or variability of glycated haemoglobin.
Systemic analysis of medication administration omission errors in a tertiary-care hospital in Quebec
Authors: Poder Thomas G , Maltais Serge 
Published: June 2018

Objective: Medication administration omission errors (MAOEs) occur frequently in hospitals and can significantly affect patient health. An interdisciplinary committee was formed in summer 2012 to analyse incident/accident reports (AH-223-1 forms) of MAOEs for the 2011–2012 fiscal year in order to identify contributing factors and to propose preventive solutions. Special attention was paid to events with consequences for patients. Method: An aggregate data analysis involving four major steps was conducted: sampling, categorisation, identification of contributing factors, and seeking preventive solutions. One hundred omissions were randomly selected from the 889 reported for this period. All omissions categorised as having had consequences for patients were then added, making a final total of 145 omissions. The omissions were categorised using an Ishikawa diagram developed from an exploratory literature review and process mapping. Subsequent to failure modes, effects and criticality analysis, cause-and-effect diagrams were constructed with the main prioritised categories to differentiate the proximal causes from the root causes. Brainstorming was used to develop solutions, which were then prioritised with an impact/effort matrix. Results: This study identified 27 categories of MAOEs, of which the 7 most frequent and the most critical accounted for 79.3% of the reports. The event categories, in decreasing order of importance, were related to intravenous (IV) therapy (29.0%), failure in using the medication administration record (MAR; 23.4%), failure in creating/updating the MAR (10.3%), medications on the patient’s bedside (7.6%), and three types of MAOEs related to transcribing prescriptions (9.0%). Conclusion: The interdisciplinary committee formulated 10 main recommendations related to these 7 categories, including 3 for IV therapy and 4 for failure in using or creating/updating the MAR.
Responsiveness of Nasal Provocation Testing—But Not Skin Test and Specific Immunoglobulin E Blood Level—Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients
Authors: Wanjun Wang , Qiurong Hu , Yanqing Xie , Mo Xian , Nili Wei , Jing Li 
Published: June 2018

Background The results of skin and blood allergen testing are not consistently relevant to clinical manifestations in allergic patients. Objective The aim of the study was to investigate the relationship between severity of allergic rhinitis and different allergen diagnostic tests in Dermatophagoides species-sensitized patients. Methods Study subjects included 65 rhinitis patients—50 with Dermatophagoides pteronyssinus (DP) sensitization (DP+) and 15 without DP sensitization (DP−), and 15 DP+ and 37 DP− healthy controls (HCs) confirmed by allergen skin prick (SPT) and blood specific immunoglobulin E (sIgE) tests. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was tested. All subjects underwent DP nasal provocation test (DP-NPT). Visual analogue scoring (VAS) of nasal symptoms and nasal airway resistance (NAR) were measured before and after NPT. Correlations between the 3 allergen tests and score of RQLQ were performed. Results All rhinitis subjects had significantly higher VAS and NAR after DP-NPT than HCs ( P < .01). All DP+ rhinitis, 40% of DP− rhinitis subjects, 13.3% of DP+ HCs and 0% of DP− HCs had positive DP-NPT. Dose of positive DP-NPT positively correlated with SPT diameter and sIgE level in all tested subjects ( P < .001). Score of RQLQ positively correlated with dose of DP-NPT ( P < .001), but not with SPT diameter and sIgE level in rhinitis patients. Conclusion Although DP nasal provocation, skin prick wheal size and blood sIgE level correlate with each other, only nasal provocation testing is associated with severity of nasal symptoms. It is suggested that NPT should be performed to verify a clinically relevant allergy.
Effects of an intensive long-term prevention programme after myocardial infarction – a randomized trial
Authors: Wienbergen Harm , Fach Andreas , Meyer Sven , Meyer Jochen , Stehmeier Janina , Backhaus Tina , Michel Stephan , Krämer Kirsten , Osteresch Rico , Schmucker Johannes , Haase Henning , Härle Tobias , Elsässer Albrecht , Hambrecht Rainer 
Published: June 2018

BackgroundLong-term risk factor control after myocardial infarction (MI) is currently inadequate and there is an unmet need for effective secondary prevention programmes.Design and methodsIt was the aim of the study to compare a 12-month intensive prevention programme (IPP), coordinated by prevention assistants and including education sessions, telephone visits and telemetric risk factor control, with usual care after MI. Three hundred and ten patients were randomized to IPP vs. usual care one month after hospital discharge for MI in two German heart centres. Primary study endpoint was the IPP Prevention Score (0–15 points) quantifying global risk factor control.ResultsGlobal risk factor control was strongly improved directly after MI before the beginning of the randomized study (30% increase IPP Prevention Score). During the 12-month course of the randomized trial the IPP Prevention Score was improved by a further 14.3% in the IPP group ( p < 0.001), while it decreased by 11.8% in the usual care group ( p < 0.001). IPP significantly reduced smoking, low-density lipoprotein cholesterol, systolic blood pressure and physical inactivity compared with usual care ( p < 0.05). Step counters with online documentation were used by the majority of patients (80%). Quality of life was significantly improved by IPP ( p < 0.05). The composite endpoint of adverse clinical events was slightly lower in the IPP group during 12 months (13.8% vs. 18.9%, p = 0.25).ConclusionsA novel intensive prevention programme after MI, coordinated by prevention assistants and using personal teachings and telemetric strategies for 12 months, was significantly superior to usual care in providing sustainable risk factor control and better quality of life.
Return to Play After Anterior Cervical Discectomy and Fusion in Professional Athletes
Authors: Watkins Robert Green , Chang David , Watkins Robert Green 
Published: June 2018

Background: Data are limited on return to play after anterior cervical discectomy fusion (ACDF) in professional athletes. Purpose: To determine the rate and time of return to play among professional athletes after ACDF. Study Design: Case series; Level of evidence, 4. Methods: This study involved the prospective and retrospective review of patient charts and diagnostic studies as well as an internet search to collect data on a consecutive series of professional athletes who underwent cervical fusion by 1 of the 2 senior authors between 1982 and 2016. Demographic data included sport, preoperative symptoms and radiologic findings, date of surgery, level of surgery, postoperative symptoms and radiologic findings, and confounding factors (eg, other orthopaedic injuries). An internet search engine was used to determine date of return to play and length of career after surgery. Results: A total of 27 ACDFs were performed on 26 professional athletes: 12 National Football League athletes, 5 National Hockey League athletes, 5 Major League Baseball athletes, 3 National Basketball Association athletes, and 1 Major League Soccer athlete. Twenty-six procedures (96.3%) showed clinical and radiographic evidence of fusion, and 20 of 25 eligible players returned to play (80%). At the conclusion of this study, 2 players were still in the rehabilitation phase and expected to return at the start of the next National Football League season. The mean time to return to play in a professional game was 9.5 months (range, 5.0-20.2 months). Of 15 players who returned to play but had retired by the time of this study, the mean career length after fusion was 3.2 years (range, 0.1-8.0 years). Clinical follow-up ranged from 1 to 96 months, with a mean of 22.1 months and mode of 11 months. Conclusion: After single-level ACDF, 80% of professional athletes were able to return to sport at approximately 9 months. The study findings will help athletes, physicians, and teams better predict outcome after ACDF surgery.
DYNAMIC PROGRAMMING AS A TOOL TO SUPPORT DECISION-MAKING FOR THE INVESTMENT PROJECT PLANNING
Authors: Архипкина Анастасия , Arkhipkina Anastasia 
Published: June 2018

Investment activity is inherent in any enterprise, as it is one of the most important aspects of its functioning, as investment decisions are often inextricably linked with the rest of the company's activities. In addition, investments form a promising organizational structure of the company and its investment culture. The most complicated geopolitical situation in the world, aimed at isolating the Russian Federation in the international economic space, leads to the need for a qualified assessment of the possibilities of implementing investment projects in the context of increasing uncertainty and risks. In this regard, the relevance of tasks to improve the efficiency of management decisions plays an important role in ensuring economic growth in the sectors of the Russian economy.
The use of dynamic programming method can be a good tool for finding the optimal distribution of investments in the absence of the possibility of full financing of the formed project
GROUNDED THEORY E NARRATIVAS DAS PRÁTICAS: UM POSSÍVEL CAMINHO METODOLÓGICO PARA O ESTUDO DA ESTRATÉGIA COMO PRÁTICA SOCIAL
Authors: Santos Leonardo Lemos da Silveira 
Published: June 2018

A despeito do crescimento e, de certo grau de consolidação já conquistado, a perspectiva da estratégia como prática ainda carece de uma discussão mais aprofundada acerca dos procedimentos metodológicos que ela requer. Como (re)fazer da prática o aspecto central da pesquisa em estratégia é uma questão ainda em aberto e que merece um pouco mais de atenção por parte dos pesquisadores. Ao que parece, é mais fácil discorrer sobre o assunto do que realizar um estudo de campo, que nos permita apreender aquilo que os estrategistas fazem no seu dia-a-dia. Menos do que descrever uma metodologia única capaz de resolver esse problema, o que pretendemos aqui é discutir a possibilidade da utilização de uma abordagem de pesquisa que combine o uso da grounded theorye das narrativas de práticas para investigações sobre a estratégia como prática. Partindo dessa articulação, acreditamos que os pesquisadores poderão compreender melhor as atividades estratégicas que os praticantes desenvolvem no cotidiano das organizações.
Effect of fixed orthodontic appliances on nonmicrobial salivary parameters
Authors: Zogakis Ioannis P. , Koren Erez , Gorelik Shlomit , Ginsburg Isaac , Shalish Miriam 
Published: June 2018

ABSTRACT

Objectives:
To examine possible changes in the levels of salivary antioxidants, C-reactive protein (CRP), cortisol, pH, proteins, and blood in patients treated with fixed orthodontic appliances.

Materials and Methods:
Salivary samples from 21 orthodontic patients who met specific inclusion criteria were collected before the beginning of orthodontic treatment (T0; baseline), 1 hour after bonding (T1), and 4–6 weeks after bonding (T2). Oxidant-scavenging ability (OSA) was quantified using a luminol-dependent chemiluminescence assay. Cortisol and CRP levels were measured using immunoassay kits. pH levels and presence of proteins and blood in the samples were quantified using strip-based tests.

Results:
A significant decrease in salivary pH was observed after bonding (P = .013). An increase in oxidant-scavenging abilities during orthodontic treatment was detected, but the change was not statistically significant. Cortisol and CRP levels slightly increased after bonding, but the difference was small without statistical significance. Changes in the presence of proteins and blood were also insignificant.

Conclusions:
Exposure to fixed orthodontic appliances did not show a significant effect on salivary parameters related to inflammation or stress, with the exception of a significant but transient pH decrease after bonding.