bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial sustainability of social enterprise in Central and Eastern Europe
Authors: Staicu Daniela 
Published: June 2018

Abstract
Recent years have seen a burgeoning interest in social enterprise across Europe. In Central and Eastern European countries, the transition to a market economy stimulated civil society initiatives, and opened new pathways for entrepreneurial initiatives, including the pioneering establishment of the first social enterprises. Eight of the Central and Eastern European countries studied acknowledge the functioning of approximately 24000 social enterprises ‘hidden’ among a variety of existing legal forms, out of which 15172 associations and foundations undertaking some economic activity. Relatively little consideration has been given to the longer-term growth and performance of these hybrid organizational forms. To succeed, these ventures must adhere to both social goals and financial constraints. It implies that common forces from multiple actors - government and other public bodies, banks, corporations, investment funds as well as individuals join efforts. Business failure among social enterprises has been attributed to various difficulties related to size, a lack of resources, and finance and funding issues. It is essential to understand which revenue streams ensure financial sustainability in the case of the social enterprise. This paper analyzes the entrepreneurial dimension of social enterprise activity in eight Central and East European countries: Bulgaria, Croatia, the Czech Republic, Hungary, Poland, Romania, Slovakia, and Slovenia, addressing the question of social enterprise revenue streams. Most social enterprises examined are aware of the need to insure financial stability to their social mission and are actively securing and combining a blend of income streams, in order to avoid overdependence on one source of income and insure sustainability. None of the countries are solely depending on market sources. Research limitations were encountered when analyzing the variety of revenue streams due to the fact that some country reports presented also the dimension of a specific revenue, whereas others do not comprise specific numbers.
IT in the workspace – The need for digital transformation
Authors: Telegescu Tiberiu 
Published: June 2018

Abstract
We live today in a world irreversibly and comprehensively impacted by the digital economy, either by its ability to transform traditional markets into digital ones or by creating new ones altogether. In such a digitized environment, agility, speed, adaptability and innovation through disruption are key attributes for organizations to maximize, in order to enable their workforce to be effective and efficient and achieve the organizational goals. The paper aims to outline that organizations have, as part of their digital transformation journey, opportunities to embrace the benefits that the new tools of the digital economy, such as cloud, mobility and big data analytics bring. The most immediate advantage of such a change is the ability to reduce the total IT spend, making the organization more frugal and allowing resources to be diverted into other ( potentially revenue generating ) parts of the business. As a method of proving that, we’ve taken several case study examples of enterprises both achieving savings by implementing new tools into their business. However, businesses often do not settle just for that but instead use part of the newly freed up resources to enhance their digital environments. Digital tools enable teams to work easily together and allow the workforce to access any and all of the organization’s resources from anywhere and at any time they wish. This “consumerized” demand model, where IT service is customized every step of the way is what lead enterprises to change their internal IT work frame and thus migrate from the legacy “one size fits all “ model, to the new, flexible, scalable and customizable model, through the usage of new capabilities like Cloud, Big Data, Analytics, Internet of Things (IoT), Mobility.
Business excellence models: a comparison
Authors: Toma Sorin-George , Marinescu Paul 
Published: June 2018

Abstract
A new approach, called “business excellence”, has emerged in the business world and scientific literature in the past decades. Facing an increasingly turbulent and chaotic environment, more and more companies have implemented business excellence strategies and made quality a key element of their business philosophy. Modern measurement frameworks were created and developed by national or international bodies such as the excellence business models. These models provide guidelines and criteria for evaluation and are used by companies across the world as groundwork for continuous improvement. The paper aims to present and compare three well-known business excellence models in the world: Malcolm Baldrige National Quality Award, the Australian Business Excellence Framework and the European Foundation for Quality Management Excellence Model. In this respect, the authors have displayed the key elements of each business excellence model, followed by their comparison. In order to achieve the previous goals, the paper uses two methods: analysis and comparison. The information were obtained from multiple secondary sources of data- books and academic journal articles from the domains of total quality management and production economics found in libraries and electronic databases- through a desk research based on a significant literature review. The paper contributes to a better understanding of the business excellence models and may help managers to design and implement business excellence strategies. The paper shows that business excellence models provide a holistic approach to continuous improvement for any type of organization. These models are based on sound values, concepts and principles and have proved their viability during the time. Consequently, they gave birth to frameworks that allow organizations to benchmark their performances and demonstrate best practices in their field of activity. Also, the research findings indicate that the American model constituted a landmark for other business excellence models around the world.
New trends in training nuclear power plant employees: probabilistic safety analysis
Authors: Tudoran Cristian 
Published: June 2018

Abstract
In the last four decades, as the nuclear industry grew and got mature, the importance of adequate risk evaluating tools became decisive. Therefore, the Probabilistic Risk Assessment (also known as Probabilistic Safety Analysis) became a cornerstone of the decisions in such high energy and high-risk industry. PSA has an internationally recognised standard, and it is supported by a group of highly trained experts, (no more than a few hundred worldwide).This work can be used as a guide for the improving the required individual and teamwork skills needed in a Probabilistic Safety Analysis - PSA Team. The necessity of such a moment in a PSA Training was imagined by Dan Serbanescu, doctor in science, nuclear energy expert, risk and safety analyst, in May 2017. After few discussions and according to recognised international standards (Probabilistic Risk Assessment procedures guide, 1983), a first time delivery was possible in the PSA Training delivered in Centrala Nuclearoelectrica Cernavoda / Nuclear Power Plant Cernavoda (2017).This article presents a systematic approach for team improvement skills, consisting of the observation, presentation of the skills required, the skills practised in the proposed exercises, the techniques used during this module (coaching included), and results. The Purpose of the newly proposed combination of training and coaching methods with the specific traditional one oriented mainly to the technical and procedural skills is to raise participants’ awareness about how soft-skills can be used in the PSA Teamwork. As Nuclear Power Plant can be easily compared with a complex organisation, soft skills are vital to be developed within the teams. PSA is becoming more required not only in nuclear but also in the aerospace industry (it was adopted by NASA - National Aeronautics and Space Administration for all future space program and by some hazardous chemical industries, as also stated in international documents (of the European Commission for instance).
Генезис інституціоналізму в працях українських учених ХХ–ХХІ ст.
Authors: Haliant Sergii 
Published: June 2018

У статті розглянуто вплив інституціоналізму на господарський розвиток суспільства, розглянуто еволюцію поглядів вітчизняних та іноземних дослідників на поняття «інституту» й «інституціоналізму», узагальнено аспекти української економічної школи інституціоналізму, структуровано етапи розвитку інституціоналізму в працях українських учених ХХ–ХХІ ст.
Особливості використання геоінформаційних систем у міжнародному туризмі
Authors: Lіutak Olena 
Published: June 2018

У статті розглянуто особливості використання інформації та геоінформаційних систем у туризмі. Визначено переваги від упровадження інформаційних ресурсів у сферу міжнародного туризму. Здійснено аналіз можливостей, що виникають при використанні інформаційних технологій у туристичній галузі.
Neurowetenschappelijke kennis en de jeugdstrafrechtsketen
Authors: Cornet Liza , de Kogel Katy 
Published: June 2018

Neuroscience and the juvenile criminal justice system
In 2017, the Research and Documentation Centre of the Ministry of Justice & Security (WODC) published the report ‘Neuroscientific application in the juvenile criminal justice system’. This report concerns an inventory of possible neuroscientific applications in the juvenile criminal justice system. The release of the report attracted attention from well-recognized national media. The positive media attention was striking for several reasons. It indicated that –in contrast to a few decades ago – it has become more accepted to study neurobiological correlates of antisocial behavior. On the other hand, the overwhelming news value indicated that the idea that antisocial behavior is also associated with neurobiological deficts has not become common knowledge yet. Based on the WODC report, in the current article the authors summarize how neuroscientific knowledge and methods could be applied in the juvenile criminal justice system.
Performance of Reverse Water Gas Shift on Coprecipitated and C‐Templated BaFe‐Hexaaluminate: The Effect of Fe Loading, Texture, and Promotion with K
Authors: Utsis Natalie , Landau Miron V. , Erenburg Alexander , Nehemya Roxana Vidruk , Herskowitz Moti 
Published: June 2018

AbstractThe effects of chemical composition, texture, and promotion with potassium of coprecipitated and carbon‐templated BaFe‐hexaaluminate catalysts on their performance in reverse water gas shift (RWGS) reaction were studied in a fixed‐bed catalytic reactor at T=350 °C, p=20 bar, H2: CO2 of 3. The methane selectivity at these conditions did not exceed 0.1 %. It was established that the rate of RWGS is strongly affected by the catalysts iron content gradually increasing up to 45 % Fe. Decreasing the catalyst nanocrystals platelets size (diameter/thickness) from 500–800/50–80 nm to 150–250/30–50 nm (SEM) by implementing the CT increased the surface area and the rates of reaction. Modeling of the redox cycle of RWGS by CO2‐TPD, TP reaction and TP reduction indicated that H2 reduction is needed for regeneration of active sites Fe2+ ions associated with oxygen vacancies. Potassium displayed a strong promotion effect on the activity of Ba−Fe‐hexaaluminates. At optimal K content of 6 wt %, the RWGS rates increased by a factor of 12–15 without changing the TOF number. This was attributed to increasing concentration of active sites due to the reduction of Fe3+ ions (XPS).
Pregnancy as a valuable period for preventing hypoxia‐ischemia brain damage
Authors: Netto C.A. , Sanches E.F. , Odorcyk F. , Duran‐Carabali L.E. , Sizonenko S.V. 
Published: June 2018

AbstractNeonatal brain Hypoxia–Ischemia (HI) is one of the major causes of infant mortality and lifelong neurological disabilities. The knowledge about the physiopathological mechanisms involved in HI lesion have increased in recent years, however these findings have not been translated into clinical practice. Current therapeutic approaches remain limited; hypothermia, used only in term or near‐term infants, is the golden standard. Epidemiological evidence shows a link between adverse prenatal conditions and increased risk for diseases, health problems, and psychological outcomes later in life, what makes pregnancy a relevant period for preventing future brain injury. Here, we review experimental literature regarding preventive interventions used during pregnancy, i.e., previous to the HI injury, encompassing pharmacological, nutritional and/or behavioral strategies. Literature review used PubMed database. A total of forty one studies reported protective properties of maternal treatments preventing perinatal hypoxia‐ischemia injury in rodents. Pharmacological agents and dietary supplementation showed mainly anti‐excitotoxicity, anti‐oxidant or anti‐apoptotic properties. Interestingly, maternal preconditioning, physical exercise and environmental enrichment seem to engage the same referred mechanisms in order to protect neonatal brain against injury. This construct must be challenged by further studies to clearly define the main mechanisms responsible for neuroprotection to be explored in experimental context, as well as to test their potential in clinical settings.
Individual responses of rodents in modelling of affective disorders and in their treatment: prospective review
Authors: Einat Haim , Ezer Itamar , Kara Nirit Z , Belzung Catherine 
Published: June 2018

AbstractIntroductionLack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals.ResultsDifferences between mice strains were studied for some decades now, and sex differences get more attention than in the past. It is suggested that one factor that is mostly neglected, individual variability within groups, should get much more attention. The importance of individual differences in behavioral biology and ecology was repeatedly mentioned but its application to models of affective illness or to the study of drug response was not heavily studied. The standard approach is to overcome variability by standardization and by increasing the number of animals per group.ConclusionsPossibly, the individuality of specific animals and their unique responses to a variety of stimuli and drugs, can be helpful in deciphering the underlying biology of affective behaviors as well as offer better prediction of drug responses in patients.
Solar Coronal Loop Dynamics Near the Null Point Above Active Region NOAA 2666
Authors: Filippov B. 
Published: June 2018

AbstractWe analyse observations of a saddle-like structure in the corona above the western limb of the Sun on 2017 July 18. The structure was clearly outlined by coronal loops with typical coronal temperature no more than 1 MK. The dynamics of loops showed convergence towards the centre of the saddle in the vertical direction and divergence in the horizontal direction. The event is a clear example of smooth coronal magnetic field reconnection. No heating manifestations in the reconnection region or magnetically connected areas were observed. Potential magnetic field calculations, which use as the boundary condition the SDO/HMI magnetogram taken on July 14, showed the presence of a null point at the height of 122 arcsec above the photosphere just at the centre of the saddle structure. The shape of field lines fits the fan-spine magnetic configuration above NOAA 2666.
An outbreak of listeriosis linked to turkey meat products in the Czech Republic, 2012–2016
Authors: Gelbíčová T. , Zobaníková M. , Tomáštíková Z. , Van Walle I. , Ruppitsch W. , Karpíšková R. 
Published: June 2018

AbstractSince 2012–2016 an increased number of listeriosis cases, especially from one region of the Czech Republic, were observed. Most of them were caused by strains of serotype 1/2a, clonal complex 8, indistinguishable by pulsed-field gel electrophoresis. Twenty-six human cases were reported, including two neonatal cases in twins. Three cases were fatal. The typing of Listeria monocytogenes isolates from food enabled to confirm a turkey meat delicatessen as the vehicle of infection for this local outbreak in the Moravian-Silesian Region. The food strains belonging to identical pulsotype were isolated from ready-to-eat turkey meat products packaged by the same producer between 2012 and 2016. This fact confirms that the described L. monocytogenes outbreak strain probably persisted in the environment of the aforementioned food-processing plant over several years. Whole-genome sequencing confirmed a very close relationship (zero to seven different alleles) between isolates from humans, foods and swabs from the environment of the food-processing plant under investigation.
An Examination of the Composition and Microstructure of Coarse Intermetallic Particles in AA2099-T8, Including Li Detection
Authors: MacRae Colin M. , Hughes Anthony E. , Laird James S. , Glenn A. M. , Wilson Nicholas C. , Torpy Aaron , Gibson Mark A. , Zhou Xiaorong , Birbilis Nick , Thompson George E. 
Published: June 2018

AbstractElectron and proton microprobes, along with electron backscatter diffraction (EBSD) analysis were used to study the microstructure of the contemporary Al–Cu–Li alloy AA2099-T8. In electron probe microanalysis, wavelength and energy dispersive X-ray spectrometry were used in parallel with soft X-ray emission spectroscopy (SXES) to characterize the microstructure of AA2099-T8. The electron microprobe was able to identify five unique compositions for constituent intermetallic (IM) particles containing combinations of Al, Cu, Fe, Mn, and Zn. A sixth IM type was found to be rich in Ti and B (suggesting TiB2), and a seventh IM type contained Si. EBSD patterns for the five constituent IM particles containing Al, Cu, Fe, Mn, and Zn indicated that they were isomorphous with four phases in the 2xxx series aluminium alloys including Al6(Fe, Mn), Al13(Fe, Mn)4 (two slightly different compositions), Al37Cu2Fe12 and Al7Cu2Fe. SXES revealed that Li was present in some constituent IM particles. Al SXES mapping revealed an Al-enriched (i.e., Cu, Li-depleted) zone in the grain boundary network. From the EBSD analysis, the kernel average misorientation map showed higher levels of localized misorientation in this region, suggesting greater deformation or stored energy. Proton-induced X-ray emission revealed banding of the TiB2 IM particles and Cu inter-band enrichment.
Biopsychosocial distress and clinical outcome in metastatic renal cell carcinoma
Authors: Bergerot Cristiane Decat , Clark Karen Lynn , Ashing Kimlin Tam , Bergerot Paulo Gustavo , Obenchain Richard , Dizman Nazli , Hsu JoAnn , Philip Errol , Loscalzo Matthew , Pal Sumanta Kumar 
Published: June 2018

AbstractObjectiveLimited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival.MethodA cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen–based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains. Association between biopsychosocial distress and clinicopathologic criteria was interrogated. Overall survival was compared between patients with low distress versus high distress.ResultHigh rates of distress (20.7%) were found among patients newly diagnosed with mRCC. Among those domains contributing to distress, pain, fatigue, and financial comorbidity were the most commonly reported by patients with mRCC. A trend toward poorer overall survival in those patients with high distress versus low distress was observed among mRCC patients.Significance of resultsBased on data from a relatively large sample of patients, this study provides the first specific insights into the potential impact of biopsychosocial distress and outcomes among patients with mRCC.
Persistierendes Foramen ovale – aktuelles Vorgehen
Authors: Schön Steffen P. , Wunderlich Carsten , Braun Martin , Kretzler Lucie , Wiedemann Stephan , Christoph Marian 
Published: June 2018

ZusammenfassungDas persistierende Foramen ovale (PFO) kann bei 25 – 30% der Bevölkerung nachgewiesen werden. Über ein PFO kann es zu einer paradoxen Embolie und zum Schlaganfall kommen. Nach neueren Studien scheint der PFO-Verschluss bei Patienten mit kryptogenem Schlaganfall embolisch-ischämische Rezidive effektiver vermeiden zu können als eine medikamentöse Therapie.
Evaluation of the Utility of von Willebrand Factor Propeptide in the Differential Diagnosis of von Willebrand Disease and Acquired von Willebrand Syndrome
Authors: Stufano Francesca , Boscarino Marco , Bucciarelli Paolo , Baronciani Luciano , Maino Alberto , Cozzi Giovanna , Peyvandi Flora 
Published: June 2018

AbstractAn increased von Willebrand factor propeptide (VWFpp) to VWF antigen (VWF:Ag) ratio (VWFpp/VWF:Ag) indicates an enhanced clearance of VWF. This finding has been described in von Willebrand disease (VWD) and in acquired von Willebrand syndrome (AVWS). A distinction between these two diseases, one congenital and the other acquired, is primarily based on family and personal history of bleeding. However, if this information is scanty, the diagnosis might be challenging due to the lack of an effective diagnostic biomarker. In this cross-sectional study, we assessed the ability of VWFpp/VWF:Ag for the differential diagnosis between VWD and AVWS. VWFpp/VWF:Ag was measured in a group of 153 patients (125 with VWD and 28 with AVWS). Most patients with AVWS and VWD showed an increased VWFpp/VWF:Ag, although to variable degrees. A marked increase of VWFpp/VWF:Ag was mainly associated with the diagnosis of AVWS and VWD type 1 Vicenza. A receiver operating characteristic curve was used to identify the optimal cutoff of VWFpp/VWF:Ag for discrimination of patients with a modestly increased (most VWD cases) versus those with a markedly increased clearance (AVWS and VWD type 1 Vicenza), and this cutoff was identified at the value of 3.9 (sensitivity: 0.70, specificity: 0.97). The ROC curve sorting from a logistic model containing VWFpp/VWF:Ag, age, and sex had an area under the curve (AUC) of 0.88 (95% confidence interval: 0.80–0.95). A subsequent molecular evaluation discriminated VWD type 1 Vicenza from AVWS. In conclusion, VWFpp/VWF:Ag appears helpful to discriminate patients with a markedly increase VWF clearance (AVWS or VWD type 1 Vicenza) from those with a modestly increased clearance (most VWD patients).
Modulation of transcriptional burst frequency by histone acetylation
Authors: Nicolas Damien , Zoller Benjamin , Suter David M. , Naef Felix 
Published: June 2018

Significance
Single-cell approaches have shown that many mammalian genes are transcribed stochastically in bursts of specific sizes and frequencies; however, molecular mechanisms controlling these bursting parameters have remained largely undetermined. By studying transcriptional bursting of a luciferase reporter controlled by a circadian gene promoter, we found that the gene integration site mainly influenced the burst size, while the circadian time primarily modulated the burst frequency. These daily variations in burst frequency correlated with histone acetylation levels, and CRISPR-Cas9–mediated acetylation of the promoter was sufficient to change the burst frequency. Since this correlation was also observed in other genes and in several cell types, we conclude that the impact of histone acetylation on gene expression is achieved mainly through modulation of burst frequency.