bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kepler-411: a four-planet system with an active host star
Authors: Sun L. , Ioannidis P. , Gu S. , Schmitt J. H. M. M. , Wang X. , Kouwenhoven M. B. N. 
Published: February 2019

We present a detailed characterization of the Kepler-411 system (KOI 1781). This system was previously known to host two transiting planets: one with a period of 3 days (R = 2.4 R⊕; Kepler-411b) and one with a period of 7.8 days (R = 4.4 R⊕; Kepler-411c), as well as a transiting planetary candidate with a 58-day period (R = 3.3 R⊕; KOI 1781.03) from Kepler photometry. Here, we combine Kepler photometry data and new transit timing variation (TTV) measurements from all the Kepler quarters with previous adaptive-optics imaging results, and dynamical simulations, in order to constrain the properties of the Kepler-411 system. From our analysis, we obtain masses of 25.6 ± 2.6 M⊕ for Kepler-411b and 26.4 ± 5.9 M⊕ for Kepler-411c, and we confirm the planetary nature of KOI 1781.03 with a mass of 15.2 ± 5.1 M⊕, hence the name Kepler-411d. Furthermore, by assuming near-coplanarity of the system (mutual inclination below 30°), we discover a nontransiting planet, Kepler-411e, with a mass of 10.8 ± 1.1 M⊕ on a 31.5-day orbit, which has a strong dynamical interaction with Kepler-411d. With densities of 1.71 ± 0.39 g cm−3 and 2.32 ± 0.83 g cm−3, both Kepler-411c and Kepler-411d belong to the group of planets with a massive core and a significant fraction of volatiles. Although Kepler-411b has a sub-Neptune size, it belongs to the group of rocky planets.
Das ZI-Track-Konzept in der modernen Psychiatrie: Eine syndromspezifische sektorenübergreifende Behandlung
Authors: Leweke F. Markus , Hirjak Dusan , Staudter Claus , Borgwedel Doris , Coenen-Daniel Maria , Heser Marco , Erk Katrin , Juckel Georg , Beivers Andreas , Meyer-Lindenberg Andreas 
Published: February 2019

ZusammenfassungDie leitliniengerechte Versorgung wiederkehrend oder chronisch psychisch kranker Menschen stellt eine Herausforderung dar, die sowohl sich entwickelnden diagnostischen und therapeutischen Möglichkeiten als auch den gesellschaftlichen und ökonomischen Rahmenbedingungen Rechnung tragen muss. Durch diese Veränderungen ergibt sich die Notwendigkeit zur Weiterentwicklung von stationären, tagesklinischen und ambulanten Behandlungsansätzen. Eine vielversprechende Behandlungsalternative bietet das sogenannte „Track-Konzept“. Ein „Track“ bzw. eine „Track-Einheit“ ist als eine symptom- und syndromspezifisch ausgerichtete, dezentral arbeitende, modular aufgebaute und an die individuellen Bedürfnisse der Patienten angepasste sektorenübergreifend integrierte stationär-teilstationär-ambulante Einheit zu verstehen. Dieses Konzept erlaubt es, Patienten über die gesamte Spanne der psychiatrischen Versorgung von der Diagnostik und Therapie in der Akutphase über die stationäre und teilstationäre Regelbehandlung bis hin zur ambulanten Betreuung ohne Brüche stadiengerecht eine Behandlungskontinuität anzubieten. Obwohl das Track-Konzept zur Verbesserung der Versorgungsqualität bei gleichzeitiger Sicherung der wirtschaftlichen Leistungsfähigkeit einer Klinik substantiell beitragen kann, stellt seine Umsetzung im klinischen Alltag eine Herausforderung dar. Die vorliegende Arbeit widmet sich den theoretischen Gesichtspunkten eines setting-übergreifenden Behandlungssystems im psychiatrisch-psychotherapeutischen Bereich. Dabei haben die Autoren den Anspruch, diese alternative Therapiemodalität aus ethischen, therapeutischen, personellen und weiterbildungsrelevanten Perspektiven zu beleuchten.
Beeinträchtigung der Sehbahn bei Glaukomen
Authors: Schmidt Manuel , Engelhorn Tobias , Dörfler Arnd , Michelson Georg 
Published: February 2019

ZusammenfassungBei Glaukomen ist die Darstellung der Sehbahn mittels Diffusionsbildgebung und metabolischer MRT möglich; es findet sich mit zunehmendem Alter eine Atrophie der Sehstrahlung, welche das Ausmaß der physiologischen Hirnvolumenminderung deutlich übersteigt. Bei den unterschiedlichen Glaukomsubtypen erlaubt die qualitative Auswertung der Diffusionsbildgebung mit Berechnung von fraktionaler Anisotropie (FA) und radialer Diffusivität (RD) die Beurteilung der axonalen Integrität entlang der Sehbahn. Es finden sich bei Glaukomen bereits im Anfangsstadium der Erkrankung deutliche FA- und RD-Veränderungen sowohl entlang der Sehbahn wie auch in weiteren Hirnregionen außerhalb der Sehbahn, die nahelegen, dass es sich beim Glaukom um eine komplexe neurodegenerative Erkrankung handelt. Die metabolische MRT wird uns künftig weitere Einblicke in die Pathophysiologie verschiedener Glaukomformen geben und damit zum Therapiemonitoring beitragen und die Diagnostik verbessern.
Die idiopathische Mauke – eine therapeutische Herausforderung
Authors: Gerdes Anja 
Published: February 2019

ZusammenfassungDie ekzematöse Dermatitis war und ist eine unangenehme und zum Teil folgenschwere Erkrankung für das Pferd – und nach wie vor eine Herausforderung bezüglich ihrer Behandlung. Auf die Hintergründe, die klinische Einteilung und Symptomatik sowie Anamnese und Diagnostik wird im Folgenden näher eingegangen. Die Überlieferungen aus der volkstümlichen Erfahrungsmedizin und alternativ- bzw. komplementärmedizinische Therapiemöglichkeiten werden kritisch erörtert.
Visual Performance, Subjective Satisfaction and Quality of Life Effect of a New Refractive Intraocular Lens with Central Extended Depth of Focus
Authors: Gillmann Kevin , Mermoud André 
Published: February 2019

Abstract
Purpose To assess the visual performance, clinical and quality of life outcomes, and subjective patient satisfaction after implantation of a new refractive/extended depth of focus (EDOF) hybrid intraocular lens (IOL).
Methods This is a monocentric, retrospective study of 29 patients (45 eyes), carried out in a tertiary care glaucoma research centre. All patients underwent implantation of a Lucidis (Swiss Advanced Vision, SAV-IOL SA, Neuchâtel, Switzerland) IOL during cataract surgery. Near, intermediate, and distance best-corrected visual acuities and uncorrected visual acuities were collected at baseline and 3 months postoperatively. Adverse events, contrast sensitivity, optical aberrations, subjective satisfaction, and spectacle independence were also analysed at 3 months.
Results At 3 months postoperatively, the mean photopic uncorrected monocular distance, and intermediate and near visual acuities were 0.2 logMAR (~ 20/32), 0.07 logMAR (~ 20/23), and 0.15 logMAR (~ 20/28), respectively. Mean best-corrected visual acuity was 0.05 logMAR (~ 20/23) for distance and 0.03 logMAR (~ 20/21) for near vision. Mean photopic contrast sensitivity was 1.5 log. The mean root mean square (RMS) was 0.119 ± 0.05 µm. Subjectively, over the 3-month follow-up, 9% of patients (n = 4) complained of halos, and 2% (n = 1) of photophobia. No other adverse events were noted.
Conclusions The Lucidis IOL demonstrates a good safety profile, with an acceptably low complication rate. While the uncorrected visual performance of this new optical design is inferior to that of other EDOF IOLs for distance vision, it achieves better results in intermediate and near vision, with consistently near-normal contrast sensitivity. Interestingly, self-reported spectacle independence and subjective patient satisfaction were high for all distances.
Antibiotikatherapie von Infektionen bei
Verbrennungspatienten – Eine systematische Übersichtsarbeit
Authors: Houschyar K.S. , Tapking C. , Duscher D. , Wallner C. , Sogorski A. , Rein S. , Pförringer D. , Reumuth G. , Weissenberg K. , Grieb G. , Branski L.K. , Siemers F. , Behr B. , Lehnhardt M. 
Published: February 2019

Zusammenfassung
Hintergrund Durch den Verlust der natürlichen Hautbarrierefunktion und
folglich reduzierter Immunkompetenz infolge eines Plasmaverlustes sowie
zahlreichen intensivmedizinischen Interventionen sind Verbrennungspatienten
besonders gefährdet für Infektionen.
Studiendesign Systematische Übersichtsarbeit
Methoden In einer systematischen Übersicht der deutsch- und
englischsprachigen Literatur zwischen 1990 und 2018 werden epidemiologische und
diagnostische Aspekte sowie der therapeutische Einsatz von Antibiotika bei
Infektionen von Verbrennungspatienten in klinischen Studien analysiert.
Ergebnisse Insgesamt erfüllten 53 randomisiert kontrollierte klinische
Studien die Auswahlkriterien. Untersucht wurden verschiedene
Arten/Applikationsformen der antibiotischen Prophylaxe bei Verbrennungswunden:
Topisch, systemisch (generell), systemisch (perioperativ), nicht absorbierbare
Antibiotika (= selektive Darmdekontamination), lokal (inhaliert) und jegliche
Applikationsformen versus Kontrolle. Die frühe „Postburn-Prophylaxe“ wurde bei
Patienten mit geringgradiger Verbrennung (sechs Studien) und Patienten mit
schwerer Verbrennung (sieben Studien) untersucht. Die antimikrobielle Prophylaxe
zeigte keine präventive Wirksamkeit des toxischen Schocksyndroms bei
geringgradigen Verbrennungen, ist aber bei Patienten mit schweren Verbrennungen
und der Notwendigkeit einer mechanischen Beatmung nützlich. Die perioperative
Prophylaxe (= Metaphylaxe) wurde in zehn Studien untersucht.
Schlussfolgerung Der Nutzen für eine längerfristige systemische
antibiotische Prophylaxe bei der Mehrheit von Verbrennungspatienten ist nicht
evident. Leichte Infektionen in stabilem klinischen Zustand sind engmaschig zu
beobachten, während bei schwerer Infektion die internationalen Sepsis-Leitlinien
und das Tarragona-Prinzip empfohlen werden.
A cumulative meta-analysis of endoscopic papillary balloon dilation versus endoscopic sphincterotomy for removal of common bile duct stones
Authors: Tringali Alberto , Rota Matteo , Rossi Marta , Hassan Cesare , Adler Douglas G. , Mutignani Massimiliano 
Published: February 2019

Abstract
Background Endoscopic papillary balloon dilation (EPBD) was introduced to overcome the risk of adverse events associated with endoscopic sphincterotomy in the removal of common bile duct (CBD) stones. We performed a meta-analysis of randomized controlled trials (RCTs) comparing efficacy and safety of EPBD vs. endoscopic sphincterotomy, focusing on stone size, balloon diameter, and balloon dilation time.
Methods A multiple database search was performed, including MEDLINE, EMBASE and Cochrane Library, from their inception date until October 2017. RCTs comparing the efficacy and safety of EPBD vs. endoscopic sphincterotomy in the removal of CBD stones were included. Cumulative meta-analyses over time, and subgroup analyses according to stone size, and balloon diameter and dilation time were carried out.
Results 25 RCTs met the inclusion criteria. Despite the cumulative meta-analysis showing a trend over time in favor of endoscopic sphincterotomy in studies published up to 2004, the conventional meta-analysis revealed that EPBD was equally efficacious compared with endoscopic sphincterotomy in stone removal at first attempt (odds ratio [OR] 0.95, 95 % confidence interval [CI] 0.65 – 1.38). Endoscopic sphincterotomy was superior to EPBD in terms of overall stone clearance (OR 0.65, 95 %CI 0.43 – 0.99) in studies published since 2002, but no differences emerged in studies using large ( ≥ 10 mm) balloons (OR 1.37, 95 %CI 0.72 – 2.62). No statistically significant difference in pancreatitis occurrence emerged between EPBD and endoscopic sphincterotomy (OR 1.35, 95 %CI 0.90 – 2.03). Pancreatitis was more common with EPBD than with endoscopic sphincterotomy in studies using balloons < 10 mm (OR 1.78, 95 %CI 1.07 – 2.97), whereas no difference emerged in studies using large balloons (OR 0.84, 95 %CI 0.46 – 1.53). EPBD had lower rates of bleeding and cholecystitis.
Conclusions Our latest data confirm that EPBD is currently inferior to endoscopic sphincterotomy in terms of overall stone clearance. However, EPBD using large balloons (≥ 10 mm) was as effective as endoscopic sphincterotomy, both in stone clearance and the need for endoscopic mechanical lithotripsy, without carrying an increased risk of pancreatitis.
Diagnosing Immune Thrombocytopenia
Authors: Sachs Ulrich J. 
Published: February 2019

AbstractAlthough the detection of a characteristic autoantibody can prove immune thrombocytopenia (ITP), this diagnosis is often based on the exclusion of other causes of thrombocytopenia. Direct glycoprotein (GP)-specific tests have the property required to demonstrate such a characteristic autoantibody. In contrast, platelet-associated immunoglobulin G or antibody detection in plasma or serum is an insufficient diagnostic test. Moreover, data for commercial capture assays are sparse and their use is currently not recommended. A significant drawback of direct GP-specific tests is their low sensitivity, and a negative test result has no relevance. It is therefore also useful to establish a diagnosis of (primarily) hyperdestructive thrombocytopenia. A full blood count together with the immature platelet fraction has an excellent positive predictive value for ITP. Plasma glycocalicin has no apparent diagnostic value in identifying ITP patients, and conflicting data for TPO preclude its use for diagnostic purposes.
Diblock copolymers enhance folding of a mechanosensitive membrane protein during cell-free expression
Authors: Jacobs Miranda L. , Boyd Margrethe A. , Kamat Neha P. 
Published: February 2019

Significance
Membrane protein folding is a critical step that underlies proper cellular function as well as the design of technologies like vesicle-based biosensors and artificial cells. Membrane composition is known to play a role in membrane protein folding; however, the specific mechanical properties of membranes that govern protein folding remain unclear. Using a highly elastic nonnatural amphiphile, we highlight the importance of a membrane mechanical property, membrane elasticity, on the spontaneous insertion and folding of a model α-helical membrane protein. Through this study, we gain a deeper understanding of cellular membrane protein folding and offer a potential approach to improve the production of membrane proteins through optimizing the mechanical properties of synthetic scaffolds present in cell-free reactions.
Defining the economic scope for ecosystem-based fishery management
Authors: Kroetz Kailin , Reimer Matthew N. , Sanchirico James N. , Lew Daniel K. , Huetteman Justine 
Published: February 2019

Significance
Ecosystem-based fisheries management provides a framework for incorporating ecological linkages between fisheries into policymaking. However, relatively little attention has been given to economic linkages between fisheries: If fishers consider multiple fisheries when deciding where, when, and how much to fish, there is potential for management decisions in one fishery to generate spillover impacts in other fisheries. We evaluate changes in participation and economic connectivity of fisheries following the implementation of Alaska’s catch-share programs. Catch shares are increasingly used worldwide and typically implemented and evaluated on a single-fishery basis. We provide evidence that changes beyond the catch-share fishery have occurred, suggesting that spillovers should be considered when designing and evaluating catch-share policies.
H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus
Authors: White Maria C. , Tao Hui , Steel John , Lowen Anice C. 
Published: February 2019

Significance
Influenza A viruses (IAV) can exchange genetic material in coinfected cells in a process termed reassortment. The last three IAV pandemic strains arose from reassortment events involving human and nonhuman IAVs. Because introduction of the hemagglutinin (HA) gene from a nonhuman virus is required for a pandemic, we addressed the compatibility of human and avian IAV. We show that sequence differences between human and avian HA genes limit the potential for reassortment. However, human IAV still incorporated heterologous HA genes at a low level in coinfected animals. This observed low level of incorporation could become significant if reassortant viruses had a fitness advantage within the host, such as resistance to preexisting immunity, and highlights the continued need for IAV surveillance.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity
Authors: Onda Masanori , Kobayashi Kazuto , Pastan Ira 
Published: February 2019

SignificanceRegulatory T cells (Tregs) protect cancer cells from immune attack. Tregs express CD25 on their surface and can be killed by antibodies and immunoconjugates targeting CD25. These agents have not been effective in controlling tumor growth, probably because they also kill cytotoxic CD8 T cells expressing CD25 that are needed for antitumor activity. To overcome these deficiencies, we have directly injected tumors with a potent anti-CD25 immunotoxin, 2E4-PE38, that kills CD25-expressing Treg cells in the tumor, causes injected and distant tumors to regress, and induces antitumor immunity. Because 2E4-PE38 is present at very low concentrations in the blood, it does not kill CD25-expressing cells at distant sites. This strategy could be employed for treating tumors in people.
Criticism and justification of negotiated compromises
Authors: Laar Jan Albert van , Krabbe Erik C. W. 
Published: February 2019

Abstract
The paper focuses on conflicts about an already negotiated compromise, taking as its example a debate in Dutch
parliament about the approval of the Paris Agreement on climate change of 2015. It deals with a variety of worries that opponents
of approval may advance and the arguments in its defense thus invited. It concludes with a profile of dialogue providing
reasonable options for those involved in such a conflict.
Deontic power and institutional contexts
Authors: Fairclough Isabela 
Published: February 2019

Abstract
In this article I study the constraints and opportunities available to decision-makers in an institutional context
(a county council), by analyzing the deliberative process that led to the rejection of an application for exploratory fracking.
Drawing on a corpus of 130,000 words, I intend to develop the theorization of argumentation in institutional contexts initiated in
pragma-dialectics (van Eemeren, 2010) by drawing on philosopher John Searle’s (2010) concept of “deontic power”. Illustrating both the restrictive and
enabling force of the institutional context, my analysis shows that, while decisions which are in keeping with institutional rules
are legitimate in the sense of being legal, the reasonableness of the institutional context itself cannot be taken for granted.
With various institutional rules in place seeming to obstruct rather than facilitate a rational decision outcome, and a local
decision, democratically arrived at, subsequently legally overturned by central government, it can be argued that bias against
local democracy was in this case built into (legal) institutional design.
“Leftie snowflakes” and other metaphtonymies in the British political discourse
Authors: Prażmo Ewelina Maria 
Published: February 2019

Abstract
The present paper deals with the use of deliberate metaphors in the political discourse. The potential of dehumanising metaphors to create derogatory descriptions used to disparage one’s political opponents is analysed. Also, metaphorical descriptions prove to be very productive in creating polysemy in previously monosemous items which are used in a new capacity in order to create an effect of novelty and surprise. This function appears especially useful in the language of politics in general, and the language of British politics in particular. The paper is maintained within the methodological framework of cognitive linguistics, focusing on the theories of conceptual metaphor and conceptual metonymy.
Individual moral otherness as a means to underscore sectoral otherness
Authors: Shukrun-Nagar Pnina 
Published: February 2019

AbstractThis study examines the news broadcasts of the Israeli TV Channel 2. It focuses on coverage of instances in whichHaredi‘Jewish ultra-Orthodox’ individuals are accused of committing immoral acts such as child abuse, hit and run accident and rape. I argue that in all of these instances, the moral otherness of these individuals is linked to theirHarediidentity, thus intensifying the negative-sectoral otherness of the entireHaredicommunity.I discuss tagging, visual devices and especially discursive strategies used to link individual moral otherness to sectoral otherness at various levels of directness. Additionally, I analyze online comments written by viewers of the items discussed, which indicate the identification and interpretation of implications and implicatures conveyed by this rhetorical linkage.
Audiological outcome for hearing preservation surgery in acoustic neuroma
Authors: Franchella S. , Borsetto D. , Mazzocco T. , Cazzador D. , Zanoletti E. 
Published: February 2019

Purpose:
Early diagnosis in acoustic neuroma (AN) has increased the prevalence of small tumors with good hearing. Otoneurological centres have increasingly aimed to preserve hearing function. The managementoptions of small ANs range from observation to active treatments (surgery, radiotherapy). No firm agreement has been made on which is the best option for audiological function preservation. Nowadays, no definitive guidelines are present in order to suggest a standard way of evaluating and comparing the hearing quality. The lack of a universally agreed hearing classification leads to the impossibility of comparing data from different centres or different therapeutic options.

Method:
The paper wantst o show, analyzing our surgical experience in hearing preservation surgery for ANs, the different results that are demonstrable by just using different hearing classification.

Results:
About the 13 patients considered ‘in protocol’ who underwent HPS, 69% are considered to have ‘good’ hearing after surgery using the Tokyo or Sanna classifications; with the AAO-HNS or the GR classifications the outcome of ‘good’ hearing preservation was 77% and in 87% with the WRS classification.

Conclusion:
A shared hearing classification is potentially the solution in order to facilitate comparison of functional outcomes across different centres or different treatment modalities.
Fibroblast Growth Factor 2 Enhances Zika Virus Infection in Human Fetal Brain
Authors: Limonta Daniel , Jovel Juan , Kumar Anil , Lu Julia , Hou Shangmei , Airo Adriana M , Lopez-Orozco Joaquin , Wong Cheung Pang , Saito Leina , Branton William , Wong Gane Ka-Shu , Mason Andrew , Power Christopher , Hobman Tom C 
Published: February 2019

Abstract
Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is not well understood. Here, we show that ZIKV infection of human fetal astrocytes (HFAs), the most abundant cell type in the brain, results in elevated expression and secretion of fibroblast growth factor 2 (FGF2). This cytokine was shown to enhance replication and spread of ZIKV in HFAs and human fetal brain explants. The proviral effect of FGF2 is likely mediated in part by suppression of the interferon response, which would represent a novel mechanism by which viruses antagonize host antiviral defenses. We posit that FGF2-enhanced virus replication in the fetal brain contributes to the neurodevelopmental disorders associated with in utero ZIKV infection. As such, targeting FGF2-dependent signaling should be explored further as a strategy to limit replication of ZIKV.