bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vildagliptin, a dipeptidyl peptidase-4 inhibitor, attenuated endothelial dysfunction through miRNAs in diabetic rats
Authors: Zhang Qian , Xiao Xinhua , Zheng Jia , Li Ming , Yu Miao , Ping Fan , Wang Tong , Wang Xiaojing 
Published: August 2019

IntroductionDipeptidyl peptidase-4 (DPP-4) inhibitors have various cellular effects that are associated with vascular protection. Here, we examined whether vildagliptin protected endothelial function in diabetic rats and explored the involved mechanism.Material and methodsExperimental diabetic rats were obtained by feeding a high-fat diet and administering an intraperitoneal injection of streptozotocin. Rats were randomly divided into four groups: controls (CON), diabetes (DM), diabetes + low dose of vildagliptin (Lvil, 10 mg/kg/day), and diabetes + high dose of vildagliptin (Hvil, 20 mg/kg/day). The metabolic parameters, endothelial function, and whole miRNA expression were measured.ResultsAfter a 12-week treatment, vildagliptin-treated rats showed a significant reduction in blood glucose and blood lipid levels. Moreover, vildagliptin recovered aortic endothelial function in diabetic rats. We identified 31 miRNAs that were differentially expressed in the Hvil group compared with the diabetic group. Importantly, through miRNA target biological function and pathway analysis, we found that vildagliptin activated miR-190-5p to inhibit Ccl2 expression and inhibited miR-134-5p and miR-375-3p to increase Bdnf and Pdk1 expression in the aorta.ConclusionsOur present study indicates that vildagliptin can recover endothelial function in diabetic rats. Anti-inflammatory and anti-apoptosis mechanisms and endothelial moderation may be the intervention targets of vildagliptin to protect the cardiovascular system through miRNA regulation.
Effects of experimental colitis in rats on incretin levels, inflammatory markers, and enteric neuronal function
Authors: Derosa Giuseppe , Maffioli Pamela , D’Angelo Angela , Cipolla Giovanna , Moro Elisabetta , Crema Francesca 
Published: August 2019

IntroductionThe aim of the study was to assess the effects of chronic inflammation on incretin levels, inflammatory markers, and enteric neuronal function measured in isolated preparations of smooth muscle of rat.Material and methodsWe induced experimental colitis using 2,4-dinitrobenzenesulfonic acid (DNBS) in 17 Albino male Sprague-Dawley rats, while 16 rats were used as a control. They were housed in temperature-controlled rooms in a 12-h light/dark cycle at 22–24°C and 50 to 60% humidity. We evaluated in both inflamed and healthy rats: fasting plasma glucose concentration, fasting plasma insulin, myeloperoxidase, active glu-cose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and GLP-2 levels, adiponectin, and C-reactive protein (CRP). We also evaluated colonic longitudinal smooth muscle contractile activity.ResultsIntrarectal administration of DNBS reduced body weight gain in inflamed rats. We recorded higher levels of fasting plasma glucose, and insulin in inflamed rats. We observed higher levels of myeloperoxidase and CRP, and lower levels of ADN in inflamed rats. We recorded higher levels of GIP, GLP-1, and GLP-2 in inflamed rats compared to the healthy ones. Regarding functional response of colon intestinal smooth muscle after electrical stimulation, we recorded a lower functional response of colon intestinal smooth muscle after electrical stimulation in inflamed rats.ConclusionsWe can conclude that chronic inflammation leads to an increase of incretin levels and to a decrease of functional response of colon intes-tinal smooth muscle after electrical stimulation.
Haemoglobin switching modulator SNPs rs5006884
is associated with increased HbA2
in β-thalassaemia
carriers
Authors: Cyrus Cyril , Vatte Chittibabu , Chathoth Shahanas , Sayed Abdul Azeez , Borgio J. Francis , Alrubaish Mohammed Abdullah , Alfalah Rawan , Alsaikhan Jana , Ali Amein K. Al 
Published: August 2019

IntroductionHaemoglobin A<sub>2</sub> (HbA<sub>2</sub>), the tetramer of α- and δ-globin chains, is used as a diagnostic biomarker for β-thalassaemia carriers. The HbA<sub>2</sub> levels are regulated by the presence of HPFH, δ-thalassaemia, HbA<sub>1/2</sub> gene triplication, and variants of KLF1, β-globin gene, and HbF regulating QTLs. Saudi Arabia has a high incidence of borderline HbA<sub>2</sub> levels, thereby making it difficult to classify the haemoglobinopathies. This study aims to investigate the association of known HbF enhancer QTL gene SNPs with HbA<sub>2</sub> levelsMaterial and methods14 Specific SNPs in BCL11A, HMIP, OR51B6, HBBP1, and HBG2 loci were genotyped in 164 Saudi β-thalassaemia carriers by TaqMan assay to validate their role as regulators of HbA<sub>2</sub> levels. HbA<sub>2</sub> levels were determined using the Variant II β-Thalassemia Short Program Recorder kit. The non-random association of these SNPs was tested using HaploView software. Protein inter-action was assessed using 3D structure modelling for OR51B6 (rs5006884), comparative energy minimisation, and root-mean-square deviation (RMSD) prediction.ResultsElevated HbA<sub>2</sub> levels were associated with SNPs in HBBP1, OR51B6, and TCT haplotype from HBG2 promoter region. The bioinformatics modelling and prediction revealed that the exonic rs5006884 had RMSD value deviations and significantly varied binding energy minimisation. α-globin variations were found in 57.92% of individuals but were not associated with elevated HbA<sub>2</sub>.ConclusionsThe haemoglobin switching modulators rs2071348, rs7482144, and rs5006884 are involved in regulation of HbA<sub>2</sub> level with rs5006884 influencing the tetramer formation. Screening for haemoglobinopathies should take these SNPs into consideration, specif-ically in borderline HbA<sub>2</sub> cases. Assiduous analysis of rs5006884 as HbA<sub>2</sub> modulator for amelioration of disease severity is recommended.
Does a high-fat diet-induced obesity model brown adipose tissue thermogenesis? A systematic review
Authors: Perez Gabriela S. , Cordeiro Gabriele D.S. , Santos Lucimeire S. , Espírito-Santo Djane D.A. , Boaventura Gilson T. , Barreto-Medeiros Jairza M. 
Published: August 2019

IntroductionIn this systematic review, we analysed studies that assessed the brown adipose tissue (BAT) activity in the high-fat/cafeteria diet model of obesity in rats.Material and methodsScopus, PubMed, Embase, and ScienceDirect databases were searched from January 2017 to November 2017. Using specific combinations of medical subject heading (MeSH) descriptors, seven papers remained after the inclusion and exclusion criteria.ResultsMost papers showed an increase in BAT thermogenesis in rodents fed high-fat/cafeteria diet. Some studies did not mention the diet composition or housing temperature, and the most of them investigated the thermogenesis superficially, being limited to the analysis of the UCP 1 expression.ConclusionsDespite the consolidated use of high-fat/cafeteria diets as a model to induce obesity, the identification of the energy expenditure arm has been slow, especially the direct quantitative assessment of the contribution of BAT to the increase in metabolic rate in rats fed a cafeteria/high-fat diet.
Circ-RHOJ.1 regulated myocardial cell proliferation
and apoptosis via targeting the miR-124-3p/NRG-1 axis
in myocardial ischemia/reperfusion injury
Authors: Liu Yan , Ke Xiao , Guo Wenyu , Wang Xiaoqing , Peng Changnong , Liao Zhiyong , Liu Qiang , Zhou Yingling 
Published: August 2019

IntroductionMyocardial ischemia/reperfusion (I/R) injury is a leading cause of cardiac dysfunction. Circular RNAs (circRNAs) are involved in the pathogenesis of myocardial I/R injury. However, the functions and underlying mechanisms are unclear. The present study determined the role of circ-RHOJ.1 in regulating myocardial cell proliferation and apoptosis after I/R injury.Material and methodsMyocardial cells isolated from Sprague-Dawley rats were identified with an immunofluorescence assay using cardiac troponin T antibody. Expression of circ-RHOJ.1, miR-124-3p and neuregulin-1 (NRG1) mRNA was assessed with real-time quantitative polymerase chain reaction. NRG1 protein expression was evaluated with western blot and immunofluorescence assays. Dual-luciferase reporter assay was performed to confirm interaction between miR-124-3p and circ-RHOJ.1, and miR-124-3p and NRG1. Effects of circ-RHOJ.1 overexpression or miR-124-3p inhibition on cell proliferation and apoptosis were evaluated using cell counting kit (CCK)-8 assay and flow cytometry. Cytokines levels were analyzed with an enzyme-linked immunosorbent assay.ResultsMyocardial cells were successfully isolated and had down-regulated expression of circ-RHOJ.1 and NRG1, and up-regulated expression of miR-124-3p after I/R injury. circ-RHOJ.1 acted as a sponge for miR-124-3p, and NRG1 served as a target gene of miR-124-3p. circ-RHOJ.1 overexpression or miR-124-3p inhibition increased interleukin (IL)-10 levels and reduced IL-2, IL-6, and tumor necrosis factor-a levels in myocardial cells after I/R injury. Functional assay results illustrated that circ-RHOJ.1 overexpression or miR-124-3p inhibition enhanced proliferation and inhibited apoptosis of myocardial cells after I/R injury.ConclusionsCirc-RHOJ.1 served as a molecular marker of myocardial I/R injury via regulation of miR-124-3p and NRG1 expression.
Effects of pre-event massage on anxiety among Nigeria national team football players: a pilot study
Authors: Kayode Shuiabu Abdulsalam , Bello Bashir 
Published: August 2019

PurposeThe purpose of the study was to examine the effect of pre-event massage on anxiety among Nigeria national team football players during the World Cup matches. As secondary outcomes, the effects of massage on blood pressure (BP) and heart rate (HR) were analysed.MethodsOverall, 17 World Cup players had massage both less and more than 24 hours prior to matches. Holey and Cook massage protocol was used. The Mental Readiness Form version 3 (MRF-3) was applied to assess anxiety level while an electronic BP monitoring kit served to monitor BP and HR before and after massage. Inferential statistic of paired t-test was carried out for the effect of massage on BP and HR.ResultsThe result of the study showed a significant difference in anxiety after massage with <i>p</i> < 0.05 at periods less and more than 24 hours before the matches. There was also a significant difference between the pre- and post-massage BP and HR at a period less and more than 24 hours before the matches (<i>p</i> < 0.05).ConclusionsPre-event massage before World Cup matches reduced anxiety among Nigeria national team football players.
Concurrent validity of the five-minute pyramid test for VO2max estimation in healthy young adults
Authors: Ronan Jacob T. , Shafer Alex B. 
Published: August 2019

PurposeMaximal oxygen uptake (VO<sub>2</sub>max) is an important physiological parameter related to sports performance and chronic disease risk. Many field tests have been developed to estimate VO<sub>2</sub>max at reduced cost, time, and energy demands compared with laboratory measurement. The purpose of this investigation is to assess the concurrent validity of the 5-minute pyramid test (5MPT).MethodsOverall, 14 young (21.1 ± 2.1 years) adult male (<i>n</i> = 7) and female (<i>n</i> = 7) participants completed 5MPT for VO<sub>2</sub>max estimation, and a criterion measurement of VO<sub>2</sub>max by using indirect calorimetry with the Bruce treadmill protocol.ResultsA strong positive correlation (<i>r</i> = 0.86, <i>p</i> < 0.0001) was observed between the estimated and measured VO<sub>2</sub>max for the entire sample. The group mean VO<sub>2</sub>max of 5MPT (3.08 ± 0.84 l ∙ min<sup>–1</sup>) was significantly lower (<i>p</i> < 0.001, Cohen’s <i>d</i> = 0.65) than the measured value of the Bruce protocol (3.68 ± 0.99 l ∙ min<sup>–1</sup>). This difference was also observed when analysing VO2max in ml ∙ kg<sup>–1</sup> ∙ min<sup>–1</sup> (37.87 ± 5.43 ml ∙ kg<sup>–1</sup> ∙ min<sup>–1</sup> vs. 46.76 ± 9.23 ml ∙ kg<sup>–1</sup> ∙ min<sup>–1</sup>, <i>p</i> < 0.001, Cohen’s <i>d</i> = 1.17), indicating a tendency to underestimate VO<sub>2</sub>max.Conclusions5MPT was designed to estimate VO<sub>2</sub>max with a submaximal, field-test approach. It may underestimate VO<sub>2</sub>max when compared with treadmill derived maximal values in healthy young adults. Additional investigations are warranted to further test the validity and reliability of 5MPT in a variety of populations.
Aerobic power, anaerobic power, and vertical jumping ability over an entire competitive period in young elite male handball players
Authors: Manou Vasiliki , Aguilera Jose Francisco Tornero , Dalamitros Athanasios A. 
Published: August 2019

PurposeThe purpose of the study was to examine the in-season variations in aerobic power, anaerobic power, and vertical jumping ability in young elite handball players in a laboratory setting.MethodsThe study involved 13 athletes (age: 19.9 ± 0.7 years, body mass: 90.0 ± 12.1 kg, height: 186.3 ± 6.3 cm, body fat percentage: 13.7 ± 4.8%), all members of the young national handball team. Maximal oxygen uptake (VO<sub>2</sub>max), Wingate Anaerobic Test (WAnT) performance (peak power [PP], mean power [MP], fatigue index [FI]), and vertical jumping ability(countermovement jump [CMJ]) were assessed on 3 occasions during the competitive period (beginning [T1], middle [T2], end [T3]).ResultsOnly slight and not significant changes were observed throughout the tested period for VO<sub>2</sub>max (T1 = 52.04 ± 4.30; T2 = 49.31 ± 3.96; T3 = 51.68 ± 5.38 ml ∙ kg–1; T1 to T3: –0.24 ± 5.83%, <i>p</i> > 0.05) and CMJ values (T1 = 46.99 ± 7.98; T2 = 46.57 ± 5.87; T3 = 48.15 ± 6.58 cm; T1 to T3: –3.26 ± 6.88%, <i>p</i> > 0.05). Similarly, all parameters evaluated during the
WAnT showed small variations (PP: T1 to T3: 1.11 ± 5.67%; MP: T1 to T3: –0.04 ± 4.34%; FI: T1 to T3: 3.43 ± 9.20%; <i>p</i> > 0.05).ConclusionsThe indices of aerobic power, anaerobic power, and vertical jumping ability remained relatively constant among the tested group of young elite athletes throughout the handball competitive period.
Translation and cross-cultural adaptation of the Polish Central Sensitization Inventory
Authors: Turczyn Paweł , Kosińska Barbara , Janikowska-Hołoweńko Dorota , Malec-Milewska Małgorzata , Marszalec Natalia , Maleszka Piotr , Tarnacka Beata 
Published: August 2019

ObjectivesThe Central Sensitization Inventory (CSI) is a new, simple clinimetric instrument intended to help doctors who deal with pain of unclear origin. It may be particularly useful when there is a large component of neuropathic pain and to assess non-specific symptoms associated with the phenomenon of central sensitization known under the common name of the central sensitization syndrome. The aim of this study is to perform translation of the CSI into Polish, its cultural adaptation and its preparation for further validation. The proposed adaptation of the scale may be applied both at the clinical level and at the level of primary care.Material and methodsThe CSI translation process took place in several stages. Firstly, the text of the questionnaire was translated from English to Polish by five independent translators. Secondly, the optimal version of the text was determined and, at the third stage, it was submitted to a linguist in order to assess it in the context of the idiomatic and semantic clarity. Thirdly, the translation was passed on to a native speaker who verified the congruence of the Polish translation with its original version. At a later stage, the effect of translating the scale and its usefulness were discussed by a group of experts in order to adapt a cultural tool. The final step was to provide it to be completed and evaluated by twenty anonymous patients with the aim of pre-assessing the level of its understanding.ResultsThe final result of the undertaken activities is the Polish version of the CSI ready for validation.ConclusionsAfter the multistage preparation and thorough verification of the Polish questionnaire at conceptual, empirical, semantic and idiomatic levels, necessary due to numerous cultural and linguistic differences, the Polish translation of the CSI seems to be a product ready for further validation and introduction to clinical practice.
The species of Ctenopelma Holmgren (Hymenoptera, Ichneumonidae) from China
Authors: Sun Shu-Ping , Li Tao , Sheng Mao-Ling , Gao Chun 
Published: August 2019

Eleven species of Ctenopelma Holmgren, 1857 are reported from China. Five species are new to science: C. labiatum Sheng, Sun & Li sp. nov., from Ningxia Hui Autonomous Region, C. lii Sheng, Sun & Li sp. nov., from Liaoning province, C. rufofasciatum Sheng, Sun & Li sp. nov., reared from Cephalcia lariciphila (Wachtl, 1898) from Beijing, C. pineatum Sheng, Sun & Li sp. nov., reared from Acantholyda posticalis (Matsumura, 1912) and Cephalcia lariciphila from Beijing and Henan, Shanxi, Shan’xi, Liaoning, Jilin and Heilongjiang provinces, and C. spiraculare Sheng, Sun & Li sp. nov., reared from Cephalcia lariciphila from Henan and Shanxi provinces. One species, C. nigrum Holmgren, 1857, reared from Cephalcia lariciphila in Beijing, is a new record for China. Ctenopelma tomentosum (Desvignes, 1856) was reared from Neurotoma sibirica Gussakovskij, 1935 (new host record) in Liaoning province. A key to species of Ctenopelma known in China is provided.
O uso de geometria dinâmica e da investigação matemática na validação de propriedades geométricas
Authors: Barbosa Lucas de Souza , Meneghetti Cinthya Maria Schneider , Poffal Cristiana Andrade 
Published: August 2019

Este artigo apresenta uma atividade sobre Geometria Espacial de posição usando o software GeoGebra, fundamentada na Investigação Matemática. A Geometria Dinâmica, através de softwares, torna-se uma ferramenta para a formação de uma imagem mental dos objetos abstratos e motivação para introduzir a ideia de justificar suas propriedades estudadas por meio de argumentos exteriores ao software. Aliada a Geometria Dinâmica, a Investigação Matemática norteia os possíveis caminhos para a construção de conjecturas e justificativas e enfatiza que, conjecturar e procurar propriedades são tão importantes quanto demonstrá-las, já que mostra a Matemática como um conhecimento em construção e favorece a evolução cognitiva da relação entre percepção e abstração. A atividade foi aplicada e observou-se que, a partir dela, o aluno consegue formular conjecturas e desenvolver habilidades de argumentação lógica e formal que são essenciais para construir entes geométricos a partir de suas propriedades.
Aplicações da Matriz Insumo-Produto em análises ambientais no Brasil: uma revisão sistemática de literatura
Authors: Castelao Raul Asseff , Souza Celso Correia de , Frainer Daniel Massen 
Published: August 2019

Diversos fatores têm contribuído para o aumento da degradação ambiental do planeta. Entre eles, o aumento da população e, consequentemente, aumento da demanda por produtos e serviços, sendo considerado um dos principais fatores geradores de externalidades para o meio ambiente. De forma a identificar ferramentas para minimizar os níveis de degradação do meio ambiente, diversas iniciativas têm sido desenvolvidas de modo a descrever a relação da economia com o meio ambiente. Como sendo um destes instrumentos, a matriz insumo-produto possibilita a descrição da relação de interdependência dos setores de uma economia com o meio ambiente de forma mais específica. Neste sentido, o objetivo deste trabalho foi o de apresentar uma revisão sistemática de literatura (RSL) sobre o uso de matriz insumo-produto com enfoque a questões ambientais no Brasil. Para tanto, foi feito uma RSL em periódicos internacionais e nacionais de modo a: quantificar e analisar os estudos disponíveis que tratam da relação do meio ambiente e matriz insumo. Foi possível identificar a existência de 1.667 artigos que trabalham com a técnica de matriz insumo-produto e o meio ambiente, sendo que deste total, 19 estudos abordam essa temática para o Brasil entre os anos de 2000 a 2018.
Kolofon
Authors: Nielsen Hans Jørn 
Published: August 2019

1. årgang, nr. 1, maj 2005ISSN 1604-7869© Forfatterne og Danmarks Biblioteksskole. Det er tilladt at kopiere frit til privat brug med tydelig kildeangivelse. Kopiering i større omfang til undervisningsbrug o.l. kan kun ske efter indhentning af forfatternes og Danmarks Biblioteksskoles tilladelse eller i henhold til kopieringsaftale med Copy-Dan.Redaktion: Hans Jørn Nielsen (ansvh.) Marianne Lykke Nielsen Camilla Moring Lennart BjörnebornRedaktører af dette nummer: Camilla Moring Lennart BjörnebornLayout: Bruno Kjær
Et andet hjem. Kvindelig Læseforenings historie 1872-1962
Authors: Worsøe-Schmidt Lisbeth 
Published: August 2019

ANMELDELSE: Helle Hvenegaard-Lassen: Et andet hjem. KvindeligLæseforenings historie 1872-1962. Museum Tusculanums Forlag og Det Kongelige Bibliotek, Serie:Danish Humanist Text and Studies. Kbh. 2008. 480sider, rigt illustreret.
Folkbibliotek makt och disciplinering. En genealogisk studie av folkbiblioteksområdet under den organiserade moderniteten
Authors: Rydbeck Kerstin 
Published: August 2019

ANMELDELSE: Andersson, Dan (2009) Folkbibliotek makt och disciplinering: en genealogisk studie av folkbiblioteksområdet under den organiserade moderniteten. Doktorsavhandlingar från Pedagogiska institutionen, nr 163. Stockholm: Stockholms universitet. 228 s. ISBN 978 91 7155 951 7. Finns även fritt tillgänglig i fulltext via SwePub: http://swepub.kb.se
Kompetencer i forskningsbibliotekerne i historisk og aktuel belysning. Udviklingsbehov i perspektiv af digitaliseringen
Authors: Hjørland Birger 
Published: August 2019

Artiklen optrækker nogle udviklingslinjer i bibliotekarers, forskningsbibliotekarers og informationsspecialisters uddannelse, kvalifikationer og kompetencer og diskuterer disse i relation til udviklingstendenserne i forskningsbibliotekernes arbejdsopgaver. Et sæt af mulige fremtidige arbejdsområder diskuteres i lyset af digitaliseringen: a) materialevalg, b) dokumentbeskrivelse med deskriptive og administrative metadata c) Emneindeksering og klassifikation d) referencearbejde og dokumentation e) fagspecifik undervisning i informationssøgning og informationskompetence f) konstruktion af fagportaler g) kommunikation med relevante fagmiljøer, herunder publikationsstøtte h) metavidenskabelig forskning samt i) det samfundspolitiske arbejde omkring bl.a. ’sikring affri og lige adgang til information og viden’. For hver af disse mulige arbejdsopgaver diskuteres de kompetencer, der skal være til stede for at udføre opgaverne kvalificeret, herunder behovet for faglig specialistviden, for informationsvidenskabelig viden og for IT-viden. Hovedkonklusionen er, at disse vidensformer ikke kan kombineres på en ydre facon, men i vidtomfang må integreres i de personer, der skal udføre arbejdsopgaverne. Implikationer for informationsvidenskabelig uddannelse belyses.