bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal aortic aneurysm as an IgG4-related disease
Authors: Prucha M , Sedivy P , Stadler P , Zdrahal P , Prokopova P , Voska L , Sedlackova L 
Published: April 2019

Summary
The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4+ plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1·35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1·20 g/l, with the number of IgG4+ plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.
Partial nomadism in large‐bodied bream (Abramis brama)
Authors: Brodersen Jakob , Hansen Joan H. , Skov Christian 
Published: April 2019

AbstractThe recent focus on a common movement ecology paradigm has increased awareness about the importance of distinguishing different movement patterns for understanding their specific impact on animal ecology and evolution. One specific form of movement is nomadism, where animals move between habitats in an arrhythmic fashion. Although not yet described in detail for freshwater fish, nomadism between lakes within drainage systems could affect local lake food webs in an otherwise unpredictable fashion. In this study, we used passive telemetry to describe inter‐lake movements of 1,280 individually tagged adult benthivorous bream (Abramis brama) over nine contiguous years in a drainage system with two paired lakes. The movements can best be described as partial nomadism, where a part of the population is neither resident nor migratory, but instead moves between lakes in a variable, arrhythmic fashion, often with long residency in one lake before moving to the other. We found extensive between‐year variation in the proportion and direction of bream moving, with higher movement propensity being partly associated with lower somatic condition. Notably, movements out of lakes were significantly more in direction of the neighbouring lake than away from the paired lakes, suggesting that at least direction was not random. Since bream are important ecosystem engineers, fluctuating densities of adult bream could affect ecological stability in lakes. Our study suggests that fish populations in interconnected lakes within drainages should not be treated as isolated units, and we discuss this in relation to lake ecology and the importance for lake ecosystem management.
Vertical movements of coastal pike (Esox lucius)—On the role of sun basking
Authors: Nordahl Oscar , Koch‐Schmidt Per , Tibblin Petter , Forsman Anders , Larsson Per 
Published: April 2019

AbstractKnowledge of patterns and drivers of the spatiotemporal distribution of top predatory fish is key to understand ecological dynamics and to successful management. Here, we integrated field and laboratory approaches to study vertical movements of pike (Esox lucius) in relation to season, light regimes and body temperature. We tagged pike from the Baltic Sea with data storage tags during spawning migration and retrieved them during migration the following years to obtain high‐resolution data from full year of movements. The results showed seasonal and diel patterns of activity and body temperature that conformed to distinct patterns of crepuscular activity and diel vertical migrations. The latter manifested as two different patterns, either a stationary phase in the surface water during day followed by night‐time in deeper water or vice versa. The occurrence of these two behaviours varied among individuals and within individuals among seasons. Diel vertical migration has previously not been described for this shallow‐dwelling species, but was a common and consistent behaviour among individuals in this study. We suggest that the function of the daytime surface behaviour in pike is to increase body temperature through sun basking. This thermoregulatory role of surfacing was supported by the laboratory study where individuals sought the surface layer, exposed themselves to infrared light and thereby attained body temperatures in excess of ambient water. These results support sun basking as a mechanism for heat gain and further suggest that access to sunlight in the surface layer could be an important driver of vertical migrations.
Do behavior and emotions improve after pediatric epilepsy surgery? A systematic review
Authors: Reilly Colin , Baldeweg Torsten , Stewart Neil , Wadhwani Suresh , Jones Chloe , Helen Cross J. , Heyman Isobel 
Published: April 2019

AbstractObjectiveThe objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow‐up) pediatric epilepsy surgery.MethodsThe systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. PubMed and EMBASE were searched from inception. Findings are described with respect to (1) changes in behavior and emotions between baseline and follow‐up, (2) factors associated with changes in behavior and emotions, and (3) impact of study quality on findings.ResultsFifteen studies met inclusion criteria. The majority of studies employed parent report screening checklists. In these studies, scores were reported to have significantly improved at follow‐up on at least one domain in seven studies and not to have changed significantly in two studies. In no studies was a deterioration in behavior noted. In studies that used Diagnostic and Statistical Manual of Mental Disorders (DSM) clinical diagnoses, no significant change was noted in the numbers of children diagnosed at baseline and at follow‐up. In total, 21 children lost diagnoses, whereas 16 children developed new diagnoses. A better seizure outcome was associated with improvements in behavioral‐emotional functioning at follow‐up in three of the four studies where it was considered. In terms of study quality, none of the studies was rated as strong (ie, had no weak ratings on a quality assessment tool).SignificanceThere is some evidence of improvement in emotional and behavioral functioning after epilepsy surgery. However, this is confined to scores on parent‐reported screening measures of emotional and behavioral symptoms and not clinical diagnoses. Future research should focus on including responses from multiple respondents (child, parent, teacher) when using screening instruments, but also diagnostic interviews. There is a need for long‐term follow‐up (beyond 2 years) with sufficiently large sample sizes including data from nonsurgery controls to understand factors associated with changes in functioning postsurgery.
Episodic and Chronic Migraine in Primary Care
Authors: Young Nathan P. , Philpot Lindsey M. , Vierkant Robert A. , Rosedahl Jordan K. , Upadhyaya Sudhindra G. , Harris Ann , Ebbert Jon O. 
Published: April 2019

ObjectiveTo inform migraine care model development by assessing differences between patients with chronic migraine (CM) and episodic migraine (EM) in the current state of treatment, disability, patient satisfaction, and quality improvement opportunities.BackgroundEfficient and focused use of scarce resources will be needed to address challenges within large populations of migraine patients.MethodsWe deployed a cross‐sectional survey study of randomly selected migraine patients within a community primary care practice.ResultsThere were 516 survey respondents (516/1804 [30%] response rate). CM patients were more likely than EM patients to report care from a neurologist (76/110 [69%] vs 229/406 [56%]; P = .0026), and higher disability according to the Migraine Disability Assessment and Headache Impact Test – 6 questionnaires (P < .0001). CM patients were less likely than EM patients to report overall satisfaction with care (16/110 [38%] vs 156/406 [66%], P = .0002), satisfaction with access to care (17/110 [33%] vs 176/406 [68%], P < .0001), and advice they needed (16/110 [31%] vs 160/406 [62%], P < .0001). Most patients with migraine had been offered triptan medications 377/516 (78%). Overall, 156/516 (31%) of individuals were currently taking any medication for migraine prevention, and 208/516 (40%) including botulinum toxin injections. CM patients were more likely to be taking preventive medication (39/110 [36%] vs 117/406 [29%], P = .0191) and report familiarity with the diagnosis of medication‐overuse headache than patients with EM (80/110 [81%] vs 256/406 [69%], P = .0178).ConclusionsWe observed differences between patients with chronic and EM and expected care delivery improvement opportunities for migraine patients in primary care. CM patients report higher levels of disability and less satisfaction with access to perceived needed medical advice and care. These findings support the need to further develop and study novel care models to efficiently and effectively deliver high‐quality care and expertise in limited supply to a diverse migraine population.
Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children
Authors: Deng Xiangling , Ma Jia , Yuan Yuan , Zhang Zhixin , Niu Wenquan 
Published: April 2019

SummaryBackgroundOverweight or obesity is increasingly recognized as a possible risk factor for childhood asthma.ObjectivesWe aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study heterogeneity.MethodsLiterature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.ResultsEighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23‐1.39; P < 0.001) and wheeze (OR = 1.90; 95% CI, 1.38‐2.63; P < 0.001), with none/marginal publication bias as revealed by the Egger test (P = 0.938/0.038), respectively. Subgroup analyses showed that children with obesity (OR = 1.40; 95% CI, 1.29‐1.52) were more likely to have asthma than children with overweight (OR = 1.22; 95% CI, 1.14‐1.31), and in children with overweight or obesity, girls (OR = 1.34; 95% CI, 1.16‐1.56) were more likely to have asthma than boys (OR = 1.27; 95% CI, 1.15‐1.40).ConclusionsOur findings indicate that overweight or obesity is a significant risk factor for childhood asthma and wheeze and in children with overweight or obesity, the risk is more evident in girls than in boys.
A cash‐constrained dynamic lot‐sizing problem with loss of goodwill and credit‐based loan
Authors: Chen Zhen , Zhang Ren‐qian 
Published: April 2019

AbstractWe consider a small retailer that manages its inventory under a strict cash constraint. At each period, the retailer's available cash restricts the maximum inventory level that it can replenish. These retailers are nanostores, which are widely present in emerging markets, or small online retailers in some Chinese e‐commerce platforms. We assume that the retailer can decide the satisfied demand quantity even if it has enough inventory, but unsatisfied demand in one period may cause customer demand to decrease in the next period considering the loss of goodwill. The retailer could adopt a credit‐based loan provided by its suppliers or e‐commerce platforms to alleviate cash shortages. A profit maximization single‐item lot‐sizing model is constructed for this problem. Numerical tests demonstrate that cash‐flow constraint is different from traditional capacity constraint, and that cash availability, as well as loan interest rate, can substantially affect a retailer's optimal lot‐sizing decisions. Our model can help a retailer decide at the beginning of the planning horizon whether it is worth applying for a credit‐based loan with a given loan policy. We prove that the zero‐inventory‐ordering property still holds for certain situations, and propose a polynomial algorithm with heuristic adjustments to solve this problem when customers' payment delay length can be neglected. If unit variable ordering costs are equal and the loss of goodwill rate is zero, the algorithm can obtain optimal solutions. Under other situations, comparisons with CPLEX 12.6.2 show that our algorithm can reach optimal performance in most cases, and it has a computation time advantage for large‐sized problems.
Single‐step preparation of rutile‐type CrNbO4 and CrTaO4 oxides from oxalate precursors–characterization and properties
Authors: Androš Dubraja Lidija , Pajić Damir , Vrankić Martina , Dragović Jure , Valant Matjaz , Benčina Metka , Jurić Marijana 
Published: April 2019

AbstractChromium niobate and tantalate (CrNbO4 and CrTaO4) were synthesized by pyrolysis of the oxalate‐based heterometallic complexes [Cr2(bpy)4(μ‐O)4Nb2(C2O4)4]·3H2O (Cr‐Nb) and [Cr(bpy)2(H2O)(μ‐O)Ta(C2O4)3]2·3.5H2O (Cr‐Ta) (bpy = 2,2'‐bipyridine). Compared to conventional solid‐state synthesis, herein studied oxides are prepared at lower temperatures, in one step without repeating grinding procedures. The structure, morphology, and optical properties of the as‐synthesized oxides were characterized using powder X‐ray diffraction (PXRD), field emission scanning electron microscopy (SEM), the thermogravimetric and differential thermal analysis (TG/DTA) and UV‐vis diffuse reflectance spectroscopy (UV‐vis DRS). The determined band gap energies of CrNbO4 and CrTaO4 are 2.39 and 2.82 eV, respectively, which prompted us to investigate photocatalytic activity of these oxides in degradation of dyes. Microscopy studies show that the particles of both oxides began to aggregate into bigger particles, leading to an increase in grain size. Additionally, magnetization measurements on both oxides revealed spin‐glass behavior at low temperatures.
The Science of Salt: Updating the evidence on global estimates of salt intake
Authors: Thout Sudhir Raj , Santos Joseph Alvin , McKenzie Briar , Trieu Kathy , Johnson Claire , McLean Rachael , Arcand JoAnne , Campbell Norman R. C. , Webster Jacqui 
Published: April 2019

AbstractThe Global Burden of Disease (GBD) 2010 study estimated national salt intake for 187 countries based on data available up to 2010. The purpose of this review was to identify studies that have measured salt intake in a nationally representative population using the 24‐hour urine collection method since 2010, with a view to updating evidence on population salt intake globally. Studies published from January 2011 to September 2018 were searched for from MEDLINE, Scopus, and Embase databases using relevant terms. Studies that provided nationally representative estimates of salt intake among the healthy adult population based on the 24‐hour urine collection were included. Measured salt intake was extracted and compared with the GBD estimates. Of the 115 identified studies assessed for eligibility, 13 studies were included: Four studies were from Europe, and one each from the United States, Canada, Benin, India, Samoa, Fiji, Barbados, Australia, and New Zealand. Mean daily salt intake ranged from 6.75 g/d in Barbados to 10.66 g/d in Portugal. Measured mean population salt intake in Italy, England, Canada, and Barbados was lower, and in Fiji, Samoa, and Benin was higher, in recent surveys compared to the GBD 2010 estimates. Despite global targets to reduce population salt intake, only 13 countries have published nationally representative salt intake data since the GBD 2010 study. In all countries, salt intake levels remain higher than the World Health Organization's recommendation, highlighting the need for additional global efforts to lower salt intake and monitor salt reduction strategies.
Research Review: Outcomes of 24‐ to 36‐month‐old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta‐analysis
Authors: Micheletti Megan , McCracken Courtney , Constantino John N. , Mandell David , Jones Warren , Klin Ami 
Published: April 2019

BackgroundDespite widespread recommendations for early surveillance of risk for autism spectrum disorder (ASD), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested that children with ASD ascertained via prospective follow‐up have better outcomes than those ascertained via community referral. Because prospective studies include early surveillance, by comparing outcomes of children with ASD across ascertainment strategies, we may gain insight into the effects of early surveillance relative to its absence.MethodsA systematic review was conducted to identify studies reporting outcomes of 24‐ to 36‐month‐olds with ASD ascertained via prospective follow‐up, community referral, or universal screening. A meta‐analysis using a random effects model was used to calculate overall effect size estimates for developmental level and symptom severity across ascertainment cohorts.ResultsEleven prospective, ten community referral, and eight universal screening studies were identified, reporting on 1,658 toddlers with ASD. We found no differences in outcomes between community referral and universal screening studies. Relative to both, prospective studies reported significantly higher developmental levels and lower symptom severities.ConclusionsOutcomes of young children with ASD ascertained via prospective follow‐up are better than those of children with ASD recruited via community referral or universal screening. Although we discuss why sampling bias is not likely the driving force behind these findings, we cannot rule out the possibility that sampling bias contributes to the observed differences; future studies should probe the effects of sociodemographic variables on clinical outcomes as a function of ascertainment strategy. This limitation notwithstanding, our results raise the possibility that prospective follow‐up may confer a ‘surveillance effect’ that contributes to improved developmental and diagnostic outcomes in children with ASD. Future research should test this hypothesis and determine the specific mechanism by which surveillance may improve outcomes.
Long‐term safety and efficacy of the sodium–glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon‐like peptide‐1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52‐week open‐label, multicenter, post‐marketing clinical study
Authors: Terauchi Yasuo , Fujiwara Hisataka , Kurihara Yuji , Suganami Hideki , Tamura Masahiro , Senda Masayuki , Gunji Ryoji , Kaku Kohei 
Published: April 2019

AbstractAims/IntroductionTofogliflozin is a potent and highly selective sodium–glucose cotransporter 2 inhibitor that is currently used to treat patients with type 2 diabetes mellitus. The aim of the present study was to evaluate the safety and efficacy of tofogliflozin add‐on to glucagon‐like peptide‐1 (GLP‐1) receptor agonist monotherapy.Materials and MethodsIn this 52‐week, prospective, multicenter, single arm, post‐marketing clinical study, Japanese patients who had already been receiving GLP‐1 receptor agonist monotherapy for ≥8 weeks, glycated hemoglobin ≥7.0 and <10.5%, and body mass index ≥18.5 and <35.0 kg/m2 were enrolled. Tofogliflozin 20 mg was orally administered once daily for 52 weeks with GLP‐1 receptor agonist. Primary end‐points were safety and change in glycated hemoglobin from baseline to week 52. Safety was assessed on the basis of the adverse events. Changes from baseline in fasting plasma glucose, bodyweight, blood pressure, uric acid and lipid parameters were assessed as secondary efficacy end‐points.ResultsOf the 67 patients enrolled, 63 patients completed the study. Overall, 26 adverse drug reactions occurred in 17 patients (25.4%). Adverse drug reactions with a frequency of two or more patients (3.0%) were constipation, thirst, dehydration and pollakiuria. Hypoglycemia (n = 1) was limited. With the addition of tofogliflozin to GLP‐1 receptor agonist, the subsequent mean (standard deviation) reduction in glycated hemoglobin was −0.6% (1.0%; P < 0.0001). Fasting plasma glucose, bodyweight and blood pressure were significantly improved.ConclusionsTofogliflozin add‐on to GLP‐1 receptor agonist monotherapy is an effective treatment option with an acceptable safety profile.
Defoliation of wild native box trees (Buxus sempervirens): Does box rust (Puccinia buxi) infection influence herbivory, survival and growth of the invasive Cydalima perspectalis?
Authors: Baur Bruno , Jung Janina , Rusterholz Hans‐Peter 
Published: April 2019

AbstractThe invasive box‐tree moth Cydalima perspectalis causes damage to horticultural box trees (Buxus spp.) in private gardens and parks in Europe and defoliation of large areas of European native box trees Buxus sempervirens, which grow in the understorey of deciduous forests. In some parts of their distribution area, wild native box trees are infected by the box rust Puccinia buxi, a fungus which does not occur in the native range of C. perspectalis. We examined whether the infection of P. buxi deters grazing by C. perspectalis in 31 wild box‐tree stands in forests in north‐western Switzerland and south‐western Germany. On average, 82.4% of the box trees were infested by P. buxi (among‐site variation 20%–100%), or 18.5% of their leaves. Linear mixed‐effect (LME) models revealed that the percentage of rust‐infected leaves was influenced by the local box‐tree density and the slope aspect of the forest site. 9.5% of the leaves showed grazing damage by C. perspectalis. LME showed that the percentage of leaves with grazing damage was affected by the elevation of the site and the percentage of rust‐infected leaves. The effect of box rust infection on food choice and larval performance (survival and growth rate) was examined in two experiments. In food‐choice tests, larvae of C. perspectalis did not show any preference for uninfected or rust‐infected box‐tree leaves and consumed similar amounts of leaf tissue of either type. However, when larvae were reared on leaves with three different degrees of P. buxi‐infection (and uninfected leaves as control), both survival and growth rate decreased with increasing degree of rust infection. This indicates that larval performance of C. perspectalis is reduced by the box rust. In the case of an outbreak of C. perspectalis, however, larvae may indiscriminately defoliate wild box trees.