bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD8‐positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides
Authors: Simo Olivia C. , Warren Simon J. , Mark Lawrence , Hoffmann Kristin , Alomari Ahmed K. 
Published: December 2018

AbstractBackgroundCD8+ lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8+ LyP.ObjectiveWe aim to study the clinical and pathologic features of cases of CD8+ LyP with no or minimal expression of CD30.Material and MethodsWe identified all cases of CD8+ LyP diagnosed in our institution over a period of 10 years. Blinded comparison of clinical and histopathologic features of cases with and without CD30 expression was performed.ResultsAmong seven cases (four patients) with definitive clinical and histopathologic diagnosis of CD8+ LyP, two cases (29%) had no expression of CD30. These two cases had more prominent epidermotropism, less epidermal ulceration, and less vascular damage relative to cases with CD30 expression and therefore resembled mycosis fungoides and type B LyP. CD5 and CD7 were frequently lost regardless of the CD30 status. Expression of cytotoxic markers was not different between the two groups. In the two cases with lack of CD30 expression, subsequent biopsies showed classic features of CD8+ LyP with strong expression of CD30.ConclusionCD8+ LyP with lack of expression of CD30 may have distinct histopathologic features that resemble mycosis fungoides and LyP type B. Clinically, they are indistinguishable from their CD30+ counterparts, signifying the importance of clinical correlation to avoid the erroneous diagnosis of lymphoma. Interval biopsies may be needed to establish a definitive diagnosis.
Rethinking the Ecclesial Mission from a Relational Viewpoint
Authors: Mazzolini Sandra 
Published: December 2018

AbstractChurch is called today to rethink its very identity more from the viewpoint of its relationships than its institutional structures, doctrine, or activities. Analogously, as the nature of the church is essentially missionary, it must rethink its evangelizing mission. This contribution deals with correlated issues. The first part introduces the ecclesiological figure of the church that “goes forth”: as the “community of missionary disciples who take the first step, who are involved and supportive, and bear fruit and rejoice” (see Evangelii Gaudium, 24). This model of church, which can be qualified as responsible, decentralized, inclusive, and dynamic, allows us to link the ecclesiological approach more closely with the anthropological one. In this framework, the second part of the contribution introduces three issues. First is the biblical notion of the imago Dei (image of God) and its implications. At the heart of common dignity lies the fact that each and every person has a trace of affinity with God, who creates and summons everyone into a personal relationship with himself and naturally orients the person to a life of communion. The second issue is the acknowledgement and integration of cultural and religious diversity from a dialogical standpoint. Recognizing the common dignity of human beings entails first acknowledging cultural and religious diversity as an element of the divine project for humankind; and then integrating it into a communal model by promoting and implementing processes of integration and adopting a dialogical methodology. The third issue is theological education and missionary training. Today, the evangelizing mission of church is pushed by the Holy Spirit even closer to the implementation of human relations with God (among human beings and with creation) and to the acknowledgement and integration of diversity in a communal model of church and mission.
Mission and Its Three Pillars
Authors: Simon Benjamin 
Published: December 2018

AbstractThe missionary movement in the 20th century started with the Edinburgh World Missionary Conference in 1910. At that time the aim was to evangelize the world in that generation. Examining the next Conferences on World Mission and Evangelism, especially Willingen (1952), reveals a paradigm shift in the understanding of mission. Mission is not about conversion, but about the three Ts: translation, transmission, and transformation. Since Arusha (2018) it has become even more obvious that mission theology needs to translate the gospel – also figuratively – into different contexts and cultures, including subcultures in our own culture and in secular contexts. It needs to transmit the gospel. Being witnesses of Christ in our world by being able to speak about our own faith is crucial when we consider the Western contexts and the distancing of the younger generation. The third T defining mission is transformation – a far more radical term than we may have wished, as it is about “turning the world upside down” (Acts 17.6). By focusing on these three Ts, mission becomes “a way of life” (Together towards Life 29).
Mission after the Arusha Conference on World Mission and Evangelism, 2018
Authors: Kim Kirsteen 
Published: December 2018

AbstractDrawing on the overall theme of the Arusha conference – “Moving in the Spirit” – this article uses personal reflections on the event as a starting point for some observations about how mission is moving and about moving forward in mission. Given the strength of Christianity in Africa, we are likely to find that it will strongly influence the mission of the future, so particular attention is paid to the African resources presented at the conference and the heritage of the East African Revival. This contribution addresses five main themes: gender justice and peace; the place of mission in the World Council of Churches (WCC); resistance to racism and marginalization; the ecclesiological implications of globalization; and renewal movements. The article sees promise in the theme of “transforming discipleship” as it arises from the WCC statement on mission and evangelism: Together towards Life (2013).
Discipleship in Creative (Un)Certainty
Authors: Jahnel Claudia 
Published: December 2018

AbstractThe theme of the World Mission Conference 2018 brings together theological terms that do not link with each other easily: mission under the main agency of the Spirit of God, transforming discipleship that involves human participation in God’s mission, and, last but not least, mission from the margins. The article highlights some marks that this tension has left on the conference in Arusha and especially on the final declaration of the mission conference, “The Arusha Call to Discipleship,” and notes an apparent move to a new “messianic” understanding of mission. This article suggests that this understanding presents a one‐sided interpretation of mission and strongly contrasts the idea developed in the last decades that the Holy Spirit is the main agent in mission. It continues by exploring how the theology of discipleship, with its wider and stricter interpretation deriving from Dietrich Bonhoeffer, the inspirations of Pentecostal pneumatology, and finally the paradigm of the mission from the margins as epistemological shift all have the potential to correct misleading concepts of mission and give new impulses for the understanding of mission today. The paper concludes by proposing creative (un)certainty as an attitude that keeps the balance between the agency of the Holy Spirit in mission – including unforeseen disruptions evoked by the free blow of the Spirit – and human discipleship.
The Arusha Call
Authors: Ross Kenneth R. 
Published: December 2018

AbstractFor the Protestant churches, the 20th century wrote a story of divergence so far as missiological understanding is concerned. Mid‐century tensions eventually led to a split into two camps, usually described as “Ecumenical” and “Evangelical.” This is a division that has run deep and been definitive for identity, association, theology, and practice in many different contexts around the world. This article argues that, by contrast, the 21st century has seen a remarkable missiological convergence as the two sides in the long‐running debate have sought to attend to each other’s concerns. This trend is evidenced by reference to significant conferences and documents, leading up to the World Council of Churches Conference on World Mission and Evangelism, held in Arusha, Tanzania, in March 2018. Examination of the “Arusha Call to Discipleship” issued by the conference reveals the extent of the convergence now taking place while also exposing its limitations. Even while acknowledging serious remaining challenges, it can be concluded that the Arusha Call is a signal of missiological convergence.
Analyzing Transformational Development as Engagement with African Millennials
Authors: Knoetze Hannes 
Published: December 2018

AbstractThis research focuses on the missiological and diaconal prospects of inclusion of the millennial generation (18–35 years of age) as agents of transformational development in Africa. Transformational development takes place on three levels to address the dichotomies of the modern worldview; spiritual world (gospel as word), seen world (gospel as deed), and the excluded middle (gospel as sign). The literature study shows that although millennials make up the largest population group in Africa, they are not adequately involved in transformational development, neither by the church nor by other agents of development. The article uses the transformational praxis “model” of Kritzinger and Saayman to discuss the possible role of millennials in transformational development in Africa, which includes several dimensions important for a holistic view of transformational development: spirituality, agency, contextual understanding, scrutiny, interpretation of tradition, discernment for action, and reflexivity.
A Study of the Acceptance and Accommodation of Calvinism in the Korean Presbyterian Church
Authors: Seong ShinHyung 
Published: December 2018

AbstractThis research delves into the acceptance and accommodation of Calvinism in the Korean Presbyterian Church, concentrating on the Pyungyang Mission Station of Chosun‐ya‐so‐kyo (Korean Presbyterian Church) in the 1900s to 1930s. It has been suggested that Chosun‐ya‐so‐kyo did not fully introduce Calvinism during this early period of Korean mission because of its historical and cultural limitations. Based on materials such as church history textbooks and academic journals, however, this study argues that Chosun‐ya‐so‐kyo clearly accommodated Calvinism as its theological foundation. In particular, the mission station’s theology education institution developed theological analysis of Calvinism through three perspectives: forging missionaries, Korean conservative theologians, and liberal theologians. Thus, the Korean Presbyterian Church adopted Calvinism as its theological groundwork.
The International Tree‐Ring Data Bank (ITRDB) revisited: Data availability and global ecological representativity
Authors: Zhao Shoudong , Pederson Neil , D'Orangeville Loïc , HilleRisLambers Janneke , Boose Emery , Penone Caterina , Bauer Bruce , Jiang Yuan , Manzanedo Rubén D. 
Published: December 2018

AbstractAimThe International Tree‐Ring Data Bank (ITRDB) is the most comprehensive database of tree growth. To evaluate its usefulness and improve its accessibility to the broad scientific community, we aimed to: (a) quantify its biases, (b) assess how well it represents global forests, (c) develop tools to identify priority areas to improve its representativity, and d) make available the corrected database.LocationWorldwide.Time periodContributed datasets between 1974 and 2017.Major taxa studiedTrees.MethodsWe identified and corrected formatting issues in all individual datasets of the ITRDB. We then calculated the representativity of the ITRDB with respect to species, spatial coverage, climatic regions, elevations, need for data update, climatic limitations on growth, vascular plant diversity, and associated animal diversity. We combined these metrics into a global Priority Sampling Index (PSI) to highlight ways to improve ITRDB representativity.ResultsOur refined dataset provides access to a network of >52 million growth data points worldwide. We found, however, that the database is dominated by trees from forests with low diversity, in semi‐arid climates, coniferous species, and in western North America. Conifers represented 81% of the ITRDB and even in well‐sampled areas, broadleaves were poorly represented. Our PSI stressed the need to increase the database diversity in terms of broadleaf species and identified poorly represented regions that require scientific attention. Great gains will be made by increasing research and data sharing in African, Asian, and South American forests.Main conclusionsThe extensive data and coverage of the ITRDB show great promise to address macroecological questions. To achieve this, however, we have to overcome the significant gaps in the representativity of the ITRDB. A strategic and organized group effort is required, and we hope the tools and data provided here can guide the efforts to improve this invaluable database.
Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment
Authors: Tien Kai‐Jen , Hung Yi‐Jen , Chen Jung‐Fu , Chen Ching‐Chu , Wang Chih‐Yuan , Hwu Chii‐Min , Huang Yu‐Yao , Hsiao Pi‐Jung , Tu Shih‐Te , Wang Chao‐Hung , Sheu Wayne Huey‐Herng 
Published: December 2018

AbstractDiabetes remains a global epidemic and a tremendous health challenge, especially in the Asian population. Dramatic increases in the prevalence of diabetes across different countries or areas in Asia have been reported in recent epidemiological studies. Although clinical guidelines have strengthened appropriate antihyperglycemic medications and lifestyle modifications for optimal diabetes management, inadequate glycemic control still occurs in many patients with an increased risk of developing microvascular and macrovascular complications. Insulin administration is the main therapy for diabetes in response to the inability to secrete insulin, and is recommended in current guidelines to treat patients with type 2 diabetes after failure of oral antidiabetic drugs. Clinical studies have shown that long‐acting insulin analogs improve basal glycemic control with reduced risk of hypoglycemia. In the present review, we discuss previous challenges with basal insulin therapy in Asia, the pharmacological development of insulin analogs to overcome the unmet medical needs and recent clinical studies of the new ultra‐long‐acting insulin analog, insulin glargine U300. Furthermore, relevant findings of current real‐world evidence are also included for the comparison of the efficacy and safety of different insulin formulations. Based on the accumulating evidence showing a low incidence of hypoglycemia and technical benefits of dose titration, treatment with glargine U300 can be a promising strategy for Asian diabetes patients to achieve glycemic targets with favorable safety.
Letter to the Editor: Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II
Authors: Wüthrich B. , Senti G. , Kündig T.M. 
Published: December 2018

Linked article: This article is commented on by A. Wollenberg et al., pp. e153–e154 in this issue. To view this article visit https://doi.org/10.1111/jdv.15384.
Same day implant bridge for full‐arch implant fixed rehabilitation
Authors: Zaninovich Michael , Petrucci Cosimo 
Published: December 2018

AbstractObjectiveTo report an alternative clinical and laboratory protocol for same‐day implant fixed full‐arch provisional rehabilitation that may overcome limitations associated with traditional immediate provisional denture conversion rehabilitation protocols.Clinical ConsiderationsThe traditional denture conversion fabrication method of an immediate full‐arch fixed provisional involves the conversion of a complete denture into a provisional fixed implant‐support prosthesis. The conversion technique has several shortcomings which compromise structural integrity, longevity, ease of modification, and the need for a silicone impression.ConclusionsThe “Same day” implant bridge (SDIB) concept provides clinical and laboratory advantages which overcome the limitations of the traditional denture conversion technique. This article reviews the rationale, clinical stages, and conventional fabrication sequence of the SDIB concept.Clinical SignificanceCompared to the traditional denture conversion method for immediate implant bridge fabrication, the SDIB technique offers the following advantages for implant‐supported fixed rehabilitation: rapid fabrication, improved structural integrity and rigidity, elimination of all silicone impressions, ease of modification to promote comfort, function and adaptability, and favorable esthetics.
Hepatic neuroendocrine carcinoma in a Japanese macaque (Macaca fuscata)
Authors: Hirata Akihiro , Miyamoto Yoko , Kaneko Akihisa , Sakai Hiroki , Yoshizaki Kyoko , Yanai Tokuma , Miyabe‐Nishiwaki Takako , Suzuki Juri 
Published: December 2018

AbstractPrimary neuroendocrine neoplasm of the liver is extremely rare in both humans and non‐human primates. The present report describes the clinical and pathological findings of an aged Japanese macaque (Macaca fuscata) with hepatic neuroendocrine carcinoma. To our knowledge, this is the first report of hepatic neuroendocrine neoplasm in macaques.
Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system
Authors: Sprenkle Neil T. , Lahiri Anirudhya , Simpkins James W. , Meares Gordon P. 
Published: December 2018

AbstractImproper protein folding and trafficking are common pathological events in neurodegenerative diseases that result in the toxic accumulation of misfolded proteins within the lumen of the endoplasmic reticulum (ER). While low‐level stimulation of the unfolded protein response (UPR) is protective, sustained UPR activation resulting from prolonged ER stress can promote neurotoxicity. The cell‐autonomous mechanisms of the UPR have been extensively characterized. However, the cell‐extrinsic role of the UPR under physiological and pathological states in the CNS remains to be elucidated. To begin to address this, we evaluated if transferring conditioned media between ER‐stressed astrocytes and neurons could modulate their functional characteristics. Our results indicate that ER‐stressed astrocytes and neurons secrete a molecule(s) with lipid characteristics which regulates both inflammatory and ER stress responses in other astrocytes, neurons, and microglia in vitro. Initial exposure to this stress factor(s) confers resistance against subsequent ER stress to neurons. However, persistent exposure to this unidentified mediator(s) suppresses the initial protective effect and becomes cytotoxic. Overall, these findings provide insight into the cell non‐autonomous influence of ER stress on cells of the central nervous system.Open Science BadgesThis article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/.
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Caring for the older person with cognitive impairment in hospital: Qualitative analysis of nursing personnel reflections on fall events
Authors: Grealish Laurie , Chaboyer Wendy , Darch Jacob , Real Belinda , Phelan Maggie , Soltau Dawn , Lunn Matthew , Brandis Susan , Todd Jo‐anne , Cooke Marie 
Published: December 2018

AbstractAims and objectivesTo explore nurse and nursing assistant reflections on the care of older patients with cognitive impairment who have experienced a fall.BackgroundWhile there are evidence‐based clinical guidelines for the prevention and management of falls and for the care of older people with cognitive impairment, the falls rates for older people with cognitive impairment are three times as high as those without.DesignCritical incident technique.MethodsEleven registered and two enrolled nurses and four assistants in nursing working in one subacute and two acute wards within two hospitals of a tertiary level health service in south‐east Queensland. Individual semistructured interviews focused on two past events when a patient with cognitive impairment had fallen in hospital: one when there was minimal harm and the second when there was significant harm. Thematic analysis was undertaken. The COREQ checklist was followed.ResultsThree themes emerged from 23 reflective accounts of fall events: “direct observation is confounded by multiple observers” and “knowing the person has cognitive impairment is not enough,” and “want to rely on the guideline but unsure how to enact it.” While participants were aware of the falls prevention policy and techniques available to prevent falls, the implementation of these was challenging due to the complexity of care required by the older person with cognitive impairment.ConclusionsFalls prevention for older people with cognitive impairment is complex and belies the simple application of policy.Relevance to clinical practiceTo reduce falls, nurses can involve the family to support “knowing the patient” to enable prediction of impulsive actions; shift the focus of in‐service from lectures to specific case presentations, with collaborative analysis on person‐focused strategies to prevent falls in older people with cognitive impairment; and reconsider the sitter role from simple observer to assistant, focused on ambulation and supporting independence in activities of daily living.
Transition to practice experiences of first‐ and second‐career nurses: A mixed‐methods study
Authors: Rainbow Jessica G. , Steege Linsey M. 
Published: December 2018

AbstractAims and objectivesTo explore the transition to nursing practice experiences of first‐ and second‐career nursing students.BackgroundTo address the nursing shortage, alternative educational programmes have been increasingly developed and implemented with to help individuals with prior career experiences transition into a career in nursing (second‐career nurses). However, we know little about the transition to practice experiences of second‐career nurses.DesignThis mixed‐methods study utilised qualitative interviews with nurses who had completed a year of practice and a longitudinal survey of nurses’ perceptions of stress, coping and burnout throughout their first year of nursing practice.MethodsQualitative data (n = 15) were analysed using latent thematic analysis and following COREQ guidelines. Descriptive and effect size analysis of quantitative data (n = 122) was conducted in order to assess for significant differences across time points.ResultsThe thematic analysis identified three themes: Stressors and Coping, Prevalence of Burnout and Presenteeism, and Difficulty Describing Nursing’s Role. The quantitative findings showed that participants’ self‐compassion decreased over their first year of practice. Levels of stress, presenteeism and burnout increased by the year mark. These increases were meaningfully significant between time points.ConclusionsDifferences in the stressors and coping of first‐ and second‐career nurses should be considered in developing transition to practice programmes for new nurses. Increasing rates of stress, burnout and presenteeism highlight the ongoing need to address these issues. Improving the nurse work environment may aid in the transition to nursing practice of both first‐ and second‐career nurses.Relevance to clinical practiceFirst‐ and second‐career nurses have increasing rates of stress, burnout and presenteeism that need to be addressed. However, there are differences in stressors and coping between first‐ and second‐career nurses.