bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Clinical Monitoring After Morphine Administration: A Retrospective Multicenter Practice Survey
Authors: Raft Julien , Podrez Kévin , Baumann Cédric , Richebé Philippe , Bouaziz Hervé 
Published: March 2019

Background:The objective of this survey was to describe the clinical monitoring practically used after intravenous, subcutaneous or neuraxial (epidural or intrathecal) administration of morphine.Methods:It was a descriptive, retrospective, multicenter (10 hospitals) survey based on the medical charts’ analysis, which evaluated the postoperative clinical monitoring after morphine administration.Results:Morphine was delivered intravenously (69%), intrathecally (19%), epidurally (10%) and/or subcutaneously (12%). Clinical monitoring protocols and protocols for the management of side effects were both present in 60% (n=6/10), only one of the two types of protocols in 10% (n=1/10) and both absent in 30% (n=3/10). Protocols for the management of respiratory depression and consciousness evaluation were present in 70% of cases (n=7/10). These events were reported on medical records without any prescription or protocol in 35% (n=14/40) and 37,5% (n=15/40) respectively. Prescriptions for respiratory rate evaluation and clinical monitoring of consciousness were in agreement with only 20% of the medical data and medical records. Different levels of respiratory rate were observed: 43% (n=3/7) below 8/min, 43% (n=3/7) below 10/min and 14% (n=1/7) below 12/min. Clinical monitoring was not performed in 31% (n=31/100) for consciousness and in 35% (n=35/100) for respiratory rate. Pulse oximeter was used in 48% (n=48/100) of patients. Capnography was never used. Respiratory depression occurred in 1% (n=1/100) of cases.Conclusion:This survey emphasizes an important disparity in the prescription of medical monitoring and a lack of use of protocols when morphine is administered. It demonstrates the need for a standardization of protocols according to the existing guidelines.
Synthesis and Investigation of Therapeutic Potential of Isoform-Specific HDAC8 Inhibitors for the Treatment of Cutaneous T Cell Lymphoma
Authors: Umamaheswari Appavoo , Puratchikody Ayarivan , Hari Natarajan 
Published: March 2019

Background:The available treatment option for any type of cancer including CTCL is chemotherapy and radiation therapy which indiscriminately persuade on the normal cells. One way out for selective destruction of CTCL cells without damaging normal cells is the use of histone deacetylase inhibitors (HDACi). Despite promising results in the treatment of CTCL, these HDACi have shown a broadband inhibition profile, moderately selective for one HDAC class but not for a particular isotype. The prevalence of drug-induced side effects leaves open a narrow window of speculation that the decreased therapeutic efficacy and observed side effects may be most likely due to non specific HDAC isoform inhibition. The aim of this paper is to synthesis and evaluates HDAC8 isoform specific inhibitors.Methods:Based on the preliminary report on the design and in silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. A series of in vitro assays in addition to HDAC8 inhibitory activity was used to evaluate the synthesised compounds.Results:Inhibitors 1e, 2e, 3e, 4e and 5e exerted the anti-proliferative activities against CTCL cell lines at 20- 100 µM concentrations. Both the pyrimidine- and pyridine-based probes exhibited μM inhibitory activity against HDAC8. The pyrimidine-based probe 1e displayed remarkable HDAC8 selectivity superior to that of the standard drug, SAHA with an IC50 at 0.1µM.Conclusion:Our study demonstrated that simple modifications at different portions of pharmacophore in the hydroxamic acid analogues are effective for improving both HDAC8 inhibitory activity and isoform selectivity. Potent and highly isoform-selective HDAC8 inhibitors were identified. These findings would be expedient for further development of HDAC8-selective inhibitors.
The Treatment of Male Infertility After Allograft Renal Transplantation: A Case Series
Authors: Takamoto Daiji , Kawahara Takashi , Takeshima Teppei , Kuroda Shinnosuke , Mochizuki Taku , Makiyama Kazuhide , Yumura Yasushi , Teranishi Jun-ichi , Uemura Hiroji 
Published: March 2019

Background:
Renal transplantation is a useful option for allowing female renal failure patients of childbearing age to achieve pregnancy. However, there have been a few reports on the effects of renal transplantation on infertility treatment in male renal failure patients. We herein report two cases in which male patients underwent infertility treatment after renal transplantation.

Case Presentation:
Case 1: A 51-year-old Asian (Japanese) man underwent transplantation (the donor was his wife) for renal failure due to Autosomal Dominant Polycystic Kidney Disease (ADPKD). At two years after transplantation, he visited the reproduction center in our institute due to infertility. A semen analysis revealed oligoasthenozoospermia. He ultimately failed to achieve pregnancy and gave up on infertility treatment.
Case 2: A 47-year-old Asian (Japanese) man underwent renal transplantation (the donor was his sister) due to renal failure caused by diabetes mellitus. At three years after renal transplantation, he visited the reproduction center in our institute for infertility. Due to ejaculation disability and the absence of sperm in the patient’s urine after masturbation, he was diagnosed with anejaculation. Thus, testicular sperm extraction (TESE) was performed. Twenty-three motile spermatozoa were successfully retrieved by microdissection TESE (micro-TESE). ICSI was subsequently performed and a good embryo was transferred. His wife achieved pregnancy and is expected to deliver this October.

Conclusion:
We report two cases of male infertility treatment after renal transplantation.
Resilience in Patients with Diabetes-Related Lower Limb Amputation
Authors: Makai Gábor , Rátvai Edina , Veszely Judit , Pethes Barbara , Kiss Enikő Csilla 
Published: March 2019

Background:Several factors may hinder postoperative rehabilitation following lower limb amputation. This study contributes to the existing knowledge of the impact of psychological factors on patients’ successful adaptation.Objective:The study focused on the importance of resilience following lower limb amputation due todiabetes mellitus, especially on protective and risk factors potentially influencing adaptation to limb loss.Method:Patients (n=29) completed a test battery one and sixth months after amputation including the following questionnaires: Beck Depression Inventory (BDI-R), Hospital Anxiety and Depression Scale (HADS), Connor-Davidson Resilience Scale (CD-RISC), Medical Outcomes Study Social Support Survey (MOS-SSS), Sense of Coherence Scale (SOC), Positive and Negative Affect Schedule (PANAS).Results:Anxiety, depression and negative emotional states negatively correlated with resilience, suggesting to be risk factors hindering adaptation. Positive effects act as a protective factor, while negative emotions hinder coping with the trauma, particularly six months after limb loss. The overall score and all three subscales of the MOS-SSS correlated positively with resilience at both measurements, which suggests that social support has importance in successfully dealing with resilience. Patients’ Sense Of Coherence (SOC) was found to be positively correlated with resilience six months after amputation suggesting it is also a protective factor.Conclusion:This study expands the limited empirical knowledge of patients with lower limb amputation due todiabetes mellitus. The study approached adaptation to limb loss from a new perspective focusing on protective and risk factors related to resilience. A complex test battery was compiled to implement the new approach to the essential protective factors in rehabilitation.
Gambaran Tingkat Kepuasan Pasien pada Pelayanan Kesehatan dengan Jamu di Rumah Riset Jamu Hortus Medicus Tawangmangu
Authors: Lestari Tri Wahyuni , Nurhayati Nurhayati , Delima Delima , Opitasari Cicih , Siswoyo Hadi 
Published: March 2019

Abstrak
Rumah Riset Jamu Hortus Medicus (RRJHM) berdasarkan Permenkes No.003/Menkes/Per/2010, merupakan klinik jamu yang melakukan kegiatan penelitian berbasis pelayanan. Sebagai bagian dari fasilitas penelitian berbasis pelayanan kesehatan, maka RRJHM terus meningkatkan kualitas pelayanannya agar senantiasa dapat memenuhi kebutuhan pasien. Salah satu aspek peningkatan mutu pelayanan adalah aspek kepuasan pasien. Penelitian ini menggunakan disain cross-sectional dan merupakan analisis lanjut dari data penelitian Model Pelayanan Kesehatan Tradisional tahun 2016. Subjek penelitian adalah pasien yang berobat di RRJHM pada saat penelitian berlangsung. Tujuan analisis untuk mengetahui gambaran tingkat kepuasan pasien yang berobat ke RRJHM. Data dianalisis secara deskriptif. Hasil penelitian menunjukkan hampir seluruh responden merasa puas terhadap pelayanan di RRJHM. Namun, masih ada beberapa responden yang berpendapat tidak atau kurang puas terhadap beberapa aspek pelayanan seperti: pelayanan yang dapat diberikan dengan cepat, selalu menanyakan keluhan pasien, selalu memberikan kesempatan bertanya kepada pasien, memberikan informasi tentang penyakit, cara pengobatan/tindakan yang dilakukan, kontra indikasi dan efek samping yang mungkin terjadi secara jelas/mudah dimengerti, memberikan edukasi tentang pola hidup sehat (diet, aktivitas fisik), prosedur administrasi yang cepat, ruangan yang tertata bersih, rapi dan nyaman.
Kata kunci: Kepuasan pasien, pelayanan kesehatan, jamu
Abstract
Based on Permenkes No.003/Menkes/Per/2010, Rumah Riset Jamu Hortus Medikus (RRJHM) is a jamu clinic that conducts service-based research activities. As part of the service based research facility, RRJHM continues to improve the quality of its services so that it can always fulfill the needs of patients. One aspect of improving the quality of service is the aspect of patient satisfaction. This cross-sectional descriptive study is an analysis of secondary data from the former research i.e.Traditional Health Service Model in 2016 that was conducted regarding patient satisfaction who visited at RRJHM. This study aims to determine the aspects of patient satisfaction at RRJHM. Data were analyzed descriptively. The results show that almost all respondents satisfied with the service at the RRJHM. However, there are still some respondents who are not satisfied with the service, especially in the aspect such as: the service is given quickly, always asks the patient’s complaint, always gives the opportunity to ask the patient, providing information about the disease, how the treatment/action is done, contra indications and side effects that may occur clearly/easily understood, providing education about healthy lifestyle (diet, physical activity), rapid administration procedures, clean, neat and comfortable room.
Keywords: patient satisfaction, health service, herbal medicine
The Impact of Benchmark Set Composition on Auditors' Level 3 Fair Value Judgments
Authors: Bhattacharjee Sudip , Moreno Kimberly K. , Wright Nicole S. 
Published: March 2019

ABSTRACT
Auditors frequently use benchmarking analysis to evaluate the appropriateness of a client's estimates. Client management may strategically select benchmark data, making an auditor's evaluation task more difficult. Psychology research suggests that the composition of the benchmark set can lead to contrast effects, because evaluations of an option in a choice set can change based on the inclusion of other options in the set. In Experiment 1, we examine and find that auditors' judgments of the reasonableness of a client-preferred discount rate for a Level 3 investment are inappropriately influenced by the set of peer companies provided by the client as justification. In Experiment 2, audit managers performing the same task similarly exhibited contrast effects. However, as managers' investment experience increased, the influence of contrast effects from the benchmark set decreased. Given the widespread use of benchmark data, contrast effects from benchmark set composition have implications for accounting and auditing contexts.
FENOMENA PERUBAHAN BENTUK BANGUNAN RUMAH TINGGAL DI DESA SODO PALIYAN, GUNUNG KIDUL
Authors: Wati Dwi Wahjoeni Soesilo 
Published: March 2019

Abstract: Dynamic changes will always occur. The aim of this research, which concerns about the phenomenon of the changes of new house form in Sodo village, is to find factors which influence changes of the building form and the varieties of changes. This research uses qualitative method. The result of this research shows that the changes of the house are affected by livelihood, limited size of the land, stages in building construction, people involved in the construction, and the openness of communication and information. Types of changes are the orientation of buildings, building form, the form of verandah, the location and shape of the main door and windows, as well as materials and building colors.Keywords: phenomenon of change, house, Sodo, Paliyan, Gunung KidulAbstrak: Perubahan merupakan dinamika yang akan selalu terjadi. Penelitian ini adalah tentang fenomena perubahan bentuk rumah baru yang terjadi di Desa Sodo. Tujuan penelitian ini adalah untuk menemukan faktor-faktor yang berpengaruh pada perubahan bentuk dan menemukan bentuk perubahannya. Penelitian menggunakan metoda kualitatif. Hasil penelitian menemukan adanya beberapa faktor yang berpengaruh pada perubahan bentuk bangunan rumah tinggal, antara lain: mata pencaharian, keterbatasan luas lahan untuk bangunan, tahapan membangun, cara membangun, dan keterbukaan komunikasi dan informasi dengan dunia luar. Perubahan yang terjadi selain pada arah hadap bangunan, juga terjadi pada sosok bangunan, bentuk serambi, bentuk dan letak pintu dan jendela, material bangunan, dan warna bangunan.Kata Kunci: fenomena perubahan,bangunan rumah tinggal, Sodo, Paliyan, Gunung Kidul
PERTIMBANGAN PENENTUAN LOKASI KAMPUNG VERTIKAL DI DAERAH TEPI SUNGAI PADA PERANCANGAN TAPAK YANG EKOLOGIS DI YOGYAKARTA
Authors: Atmadji Andreas , Putra Aulia Ramdhana Adi 
Published: March 2019

Abstract: This research starts from the existence of slums in areas are not intended for settlement or has not been managed well by the government such as the riverside that established by low income people (MBR). slums in Yogyakarta give the negative impact that is declining quality of society and environment. Vertical village became one of the solutions the housing needs. Determination and processing of good location being the initial success of the dwelling environment. With inductive-descriptive method expected to results of this research provide direction or consideration in determining the location of flats as the basis for the design of vertical riverside village on ecological footprint design in Yogyakarta.Keywords : riverside, vertical village, housing, ecologicalAbstrak: Penelitian ini berawal dari keberadaan kawasan kumuh di wilayah-wilayah yang tidak diperuntukkan untuk hunian atau belum dikelola baik oleh pemerintah seperti di bantaran sungai yang didirikan oleh masyarakat berpenghasilan rendah (MBR). Terbentuknya kawasan kumuh di Yogyakarta memberikan dampak negatif yaitu menurunnya kualitas hidup dan sosial masyarakat serta lingkungan. Kampung vertikal menjadi salah satu solusi untuk pemenuhan kebutuhan hunian. Penentuan dan pengolahan lokasi yang baik menjadi awal keberhasilan lingkungan hunian. Dengan metode induktif deskriptif diharapkan hasil penelitian dapat memberikan arahan atau pertimbangan dalam penentuan lokasi rumah susun sebagai dasar perancangan kampung vertikal tepi sungai pada perancangan tapak yang ekologis di Yogyakarta.Kata kunci : bantaran sungai, kampung vertikal, hunian, ekologis
TINJAUAN NORMATIF TENTANG PERLINDUNGAN HUKUM TERHADAP ANAK KORBAN KEKERASAN DALAM RUMAH TANGGA
Authors: Mayasari Dian Ety 
Published: March 2019

AbstractViolence against children is a violation of children's rights, especially if the abuser is the child's own parents, this is called domestic violence. The government had ratified legislation governing child rights and protection of children in Indonesia with sanctions for perpetrators who violate, but sanctions are more focused on criminal sanctions, when in fact it could be the imposition of civil penalties by filing a compensation lawsuit against the perpetrators based on Article 1365 of the Code of Civil Law concerning unlawful act that is broadly defined, not only violate the law but also violated decency and public order.Keywords: Violence, Children, VictimsIntisariKekerasan pada anak merupakan pelanggaran hak anak, apalagi jika pelaku kekerasan ini adalah orang tua anak itu sendiri, hal ini disebut kekerasan dalam rumah tangga. Pemerintah sudah mengesahkan peraturan tentang hak-hak anak dan perlindungan bagi anak di Indonesia dengan adanya sanksi bagi pelaku yang melanggar, namun sanksinya lebih berfokus pada sanksi pidana, padahal sebenarnya bisa juga sanksi perdata dengan mengajukan gugatan ganti rugi pada pelaku berdasarkan Pasal 1365 Kitab Undang-Undang Hukum Perdata tentang perbuatan melawan hukum yang diartikan secara luas, tidak hanya melanggar undang-undang namun juga melanggar kesusilaan dan ketertiban umum.Kata Kunci : Kekerasan, Anak, Korban
IDENTIFIKASI DAN VALIDITAS NORMA-NORMA JUS COGENS DALAM HUKUM INTERNASIONAL
Authors: Luhulima Hendro Valence 
Published: March 2019

This paper would like to examine the requirements and validity of jus cogens. This is very important because jus cogens itself is very difficult to identify. This ambiguity makes jus cogens a controversial norm, and is considered not to provide legal certainty. Moreover, in terms of the implementation of the norm. In this regard, I will provide some alternative requirements of a norm as jus cogens, and a brief review of the validity of jus cogens inferred from the opinions of international legal experts and the provisions of the Vienna Convention 1969 on the Law of Treaties.Keywords: Jus cogens, international law, Vienna Convention on the law of treaties 1969. IntisariTulisan ini hendak mengkaji persyaratan dan validitas dari jus cogens. Hal ini dianggap penting sebab jus cogens itu sendiri sangat sulit untuk diidentifikasikan. Ketidakjelasan ini membuat jus cogens sebagai norma yang kontroversial, dan dianggap tidak memberikan kepastian hukum. Terlebih lagi dalam hal pemberlakuan norma tersebut. Berkaitan dengan hal tersebut, tulisan ini akan memberikan beberapa alernatif persyaratan suatu norma sebagai jus cogens, dan kajian singkat mengenai validitas pemberlakuan jus cogens yang disimpulkan dari pendapat-pendapat ahli hukum internasional dan ketentuan Konvensi Wina 1969 tentang Hukum Perjanjian Internasional.Kata Kunci: Jus cogens, hukum internasional, Konvensi Wina Tahun 1969 tentang Hukum Perjanjian Internasional.
THE IMPACT OF PANCASILA AS THE STATE IDEOLOGY OF INDONESIA TOWARD THE PROVISION ON DEATH PENALTY IN THE PENAL CODE BILL
Authors: Munthe Cesar Antonio , Soge Paulinus 
Published: March 2019

Pancasila has been the state ideology of Indonesia since the day after the independence of Indonesia that is on the 18th of August 1945. It was formulated by our founding fathers by taking our own values and cultures inherited by our ancestors from some old kingdoms such as Kutai in Kalimantan, Sriwijaya in Sumatra, and Majapahit in Java. One year after the independence on the 17th of August 1945, Indonesian government promulgated Law No. 1 Year 1946 concerning The Penal Code on 26th of February 1946. Through this law the government at that time stated that Wetboek van Strafrecht voor Nederlandsch-Indie (W.v.S. Ned. Indie (S. 1915 No. 732) as the main written penal code and was formally called Kitab Undang-undang Hukum Pidana (KUHP) which in Article 10 provides death penalty as the heaviest main punishment. Dealing with that provision there has been a long debate among Indonesian people whether death penalty is in accordance with Pancasila or not. Netherlands as the home base of death penalty dropped it out from its penal code in 1870 because of the strong struggle of human right proponents. In Indonesia a research carried out in 1981/1982 by The Law Faculty of Undip collaborating with the The Supreme Court found out that both proponents and opponents of death penalty used Pancasila as “justification”. In the effort to give respect to both parties legal drafters of the Penal Code Bill provide death penalty as “specific punishment” and put it out of the main punishment in the Penal Code Bill.Key Words: Pancasila, State ideology, Legal drafters, Specific punishment, The Penal Code Bill.
Waves of identity: Reflections on the terms “indigenous” and “indigeneity”
Authors: Sasa-Tepania Latoia 
Published: March 2019

Throughout my childhood upbringing, the term Indigenous was never once used in my household. I identify myself as a Samoa, Maori woman. If someone were to ask me of my birthplace, Aotearoa would be the first name I reply with before New Zealand.
My father, a proud Samoa man, who acknowledges his village of birth being Papasataua, Savaii born o n the island of Samoa; is how he introduces himself. My beautiful mother, who identifies herself as mana wahine born Manaia, Taranaki. A child of the Whakatutu, Tepania whanau line.
Both of my parents never used the terms Indigenous or indigeneity to introduce who they are, or as a sentence starter to explain their connection to land, sea or people.
In recent years, it has come to my attention the term Indigenous, is not only spoken often in and around my place of study; but also, printed several times within the tertiary provider’s prospectus.
I begin to think; now is an excellent time to explore and look at the relevance, of the term concerning the New Zealand context, field of practice and I as a practitioner.
It is with hopes my findings and personal views, help you the reader, start to think and really look at the types of words people place on you.
After all, who likes being called names. Instead I, myself give the right to a name; then have a n ame give its power to define me.
Manu Tū Rangatira
Authors: Tekaharoa Potts Romana 
Published: March 2019

From this awesome world of being a Tangata Whenua and being enlightened in all aspects of Te Ao maarama from my Whaea, and many Rangatira I connected with I set forth on my journey into the world of light and discovered our Manu Rangatira. The kōrero being passed down to me flawless as the Kūkupa Harakore, about our Manu being the first to lay their foundation upon the whenua including their tikanga. Being created by Tāne before the ira tangata, they are our tuākana, our elders. My tūpuna had so much manaakitanga for our manu that they followed in their footsteps, the many tikanga of the bush and land and also seasonal cycles for food gathering and natural survival. Aotearoa was a land of Manu whenua. Many could fly, but as there were no real predators around, many chose to walk through the great forests of Tāne. As I filled my kete with all these treasures from meeting many great Pouako along my journey of life, I wove the wānanga of these Manu with the way they moved and walked as Rangatira on our whenua, thus creating.....