bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of tumor margins using diffuse reflectance spectroscopy with an extended‐wavelength spectrum in a porcine model
Authors: Dahlstrand U. , Sheikh R. , Nguyen C. D. , Hult J. , Reistad N. , Malmsjö M. 
Published: May 2018

ObjectiveA novel extended‐wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non‐invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.Materials and methodsExtended‐wavelength diffuse reflectance spectroscopy recordings (350‐1550 nm) were made on 13 pigmented skin lesions and non‐pigmented skin, as a reference. The hand‐held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS‐defined border and the histological border was measured by 3 independent examiners.ResultsThe median difference between the EWDRS‐defined border and the histological border was 70 μm toward the pigmented tissue (range: −579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.ConclusionsExtended‐wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non‐invasive tumor margin delineation in the future.
Laboratory assessment of the quality of adult and neonatal red cell concentrates manufactured from whole blood, exchange transfusion or intrauterine transfusion red cell units
Authors: Meli A. , New H. , McAndrew M. , Wiltshire M. , Cardigan R. 
Published: May 2018

BackgroundWe evaluated the quality of red cell components in additive solution over 42 days of storage when re‐manufactured from neonatal exchange transfusion (ExTx) or intrauterine transfusion (IUT) units on day 7 for issue to adults, neonates or infants.Materials and methodsRed cell concentrates (RCC) manufactured from WB were compared to RCC re‐manufactured from ExTx or IUT on day 7, and red cell splits (RCS) manufactured from WB were compared to RCS re‐manufactured from ExTx or IUT on day 7. All components were stored at 2–6°C and tested throughout storage until day 42 for in vitro parameters of red cell quality. One RCS manufactured from each of WB, ExTx or IUT, was irradiated on day 14 and tested on day 28 along with a non‐irradiated RCS from the same unit.ResultsAll the re‐manufactured arms had no worse haemolysis, red cell microvesicle (RCMV) release or ATP over storage compared to controls. All arms complied with the 0·8% haemolysis UK specification, except for re‐manufactured RCS from the IUT arm irradiated on day 14 and tested on day 28. Re‐manufactured units had significantly decreased potassium levels compared to control over storage (P < 0·001 all).ConclusionRCC or RCS re‐manufactured from ExTx or IUT units on day 7 are suitable for transfusion up to the standard day 35 of storage. Re‐manufactured RCS from ExTx units (but not IUT), may be irradiated up to day 14 and stored for 14 days post‐irradiation.
Efficacy of vaporized hydrogen peroxide for repeated sterilization of a single‐use single‐incision laparoscopic surgery port
Authors: Scharf Valery F. , Dent Brian , Jacob Megan E. , Moore Brandon 
Published: May 2018

AbstractObjectiveTo determine the ability of vaporized hydrogen peroxide (VHP) to sterilize a single‐use single‐incision laparoscopic surgery port and its associated components after repeated simulated uses.Study designProspective in vitro experimental study.Sample populationSix single‐use single‐incision laparoscopic surgery ports with associated cannulas and insufflation tubing.MethodsPorts, cannulas, and tubing were subjected to 10 cycles of simulated use, bacterial inoculation with Staphylococcus pseudintermedius and Escherichia coli, decontamination and sterilization, and testing via culture based on their treatment group designation. Bacteriological scores were compared among the negative control, positive control, and 4 treated ports and components.ResultsThere was no difference in bacteriological scores between treated ports, cannulas, and insufflation tubing and the negative control port and components. Bacteriological scores of ports and components undergoing 6‐10 cycles were not significantly different from scores of ports and components undergoing 5 or fewer sterilization cycles. No difference was found in detection of bacteria from treated ports by biopsy of the foam versus sampling via wash.ConclusionThis study suggests that a single‐use single‐incision laparoscopic port and its associated components can be effectively sterilized after multiple simulated uses by using VHP.Clinical significanceReuse of a single‐use single‐incision laparoscopic port is a safe and effective method of cost reduction in veterinary patients.
Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome
Authors: Singh Preeti , Mahmoud Ranim , Gold June-Anne , Miller Jennifer L , Roof Elizabeth , Tamura Roy , Dykens Elisabeth , Butler Merlin G , Driscoll Dan J , Kimonis Virginia 
Published: May 2018

IntroductionPrader-Willi syndrome (PWS) is a complex genetic disorder associated with three different genetic subtypes: deletion of the paternal copy of 15q11-q13, maternal UPD for chromosome 15 and imprinting defect. Patients are typically diagnosed because of neonatal hypotonia, dysmorphism and feeding difficulties; however, data on the prenatal features of PWS are limited.ObjectiveThe aim of the study was to identify and compare frequencies of prenatal and neonatal clinical features of PWS among the three genetic subtypes.MethodsData from 355 patients with PWS from the Rare Diseases Clinical Research Network PWS registry were used to analyse multiple maternal and neonatal factors collected during an 8-year multisite study.ResultsAmong our cohort of 355 patients with PWS (61% deletion, 36% UPD and 3% imprinting defect) 54% were born by caesarean section, 26% were born prematurely and 34% with a low birth weight (frequencies 32%, 9.6% and 8.1%, respectively, in the general population). Fetal movements were reported as decreased in 72%. All babies were hypotonic, and 99% had feeding difficulties. Low Apgar scores (<7) were noted in 17.7% and 5.6% of patients, respectively, compared with 1% and 1.4%, respectively, in the general population. Maternal age and pre-pregnancy weight were significantly higher in the UPD group (p=0.01 and <0.001, respectively).ConclusionWe found a higher rate of perinatal complications in PWS syndrome compared with the general population. No significant differences in the genetic subtypes were noted except for a higher maternal age and pre-pregnancy weight in the UPD subgroup
Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease
Authors: Liem David A. , Murali Sanjana , Sigdel Dibakar , Shi Yu , Wang Xuan , Shen Jiaming , Choi Howard , Caufield John H. , Wang Wei , Ping Peipei , Han JiaWei 
Published: May 2018

Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. Using a novel bioinformatics text-mining tool, we studied six categories of cardiovascular disease (CVD), namely, ischemic heart disease, cardiomyopathies, cerebrovascular accident, congenital heart disease, arrhythmias, and valve disease, anticipating novel ECM protein-disease and protein-protein relationships hidden within vast quantities of textual data. We conducted a phrase-mining analysis, delineating the relationships of 709 ECM proteins with the 6 groups of CVDs reported in 1,099,254 abstracts. The technology pipeline known as Context-Aware Semantic Online Analytical Processing was applied to semantically rank the association of proteins to each CVD and all six CVDs, performing analyses to quantify each protein-disease relationship. We performed principal component analysis and hierarchical clustering of the data, where each protein was visualized as a six-dimensional vector. We found that ECM proteins display variable degrees of association with the six CVDs; certain CVDs share groups of associated proteins, whereas others have divergent protein associations. We identified 82 ECM proteins sharing associations with all 6 CVDs. Our bioinformatics analysis ascribed distinct ECM pathways (via Reactome) from this subset of proteins, namely, insulin-like growth factor regulation and interleukin-4 and interleukin-13 signaling, suggesting their contribution to the pathogenesis of all six CVDs. Finally, we performed hierarchical clustering analysis and identified protein clusters predominantly associated with a targeted CVD; analyses of these proteins revealed unexpected insights underlying the key ECM-related molecular pathogenesis of each CVD, including virus assembly and release in arrhythmias. NEW & NOTEWORTHY The present study is the first application of a text-mining algorithm to characterize the relationships of 709 extracellular matrix-related proteins with 6 categories of cardiovascular disease described in 1,099,254 abstracts. Our analysis informed unexpected extracellular matrix functions, pathways, and molecular relationships implicated in the six cardiovascular diseases.
Practical Predictability of Supercells: Exploring Ensemble Forecast Sensitivity to Initial Condition Spread
Authors: Flora Montgomery L. , Potvin Corey K. , Wicker Louis J. 
Published: May 2018

Abstract
As convection-allowing ensembles are routinely used to forecast the evolution of severe thunderstorms, developing an understanding of storm-scale predictability is critical. Using a full-physics numerical weather prediction (NWP) framework, the sensitivity of ensemble forecasts of supercells to initial condition (IC) uncertainty is investigated using a perfect model assumption. Three cases are used from the real-time NSSL Experimental Warn-on-Forecast System for Ensembles (NEWS-e) from the 2016 NOAA Hazardous Weather Testbed Spring Forecasting Experiment. The forecast sensitivity to IC uncertainty is assessed by repeating the simulations with the initial ensemble perturbations reduced to 50% and 25% of their original magnitudes. The object-oriented analysis focuses on significant supercell features, including the mid- and low-level mesocyclone, and rainfall. For a comprehensive analysis, supercell location and amplitude predictability of the aforementioned features are evaluated separately.
For all examined features and cases, forecast spread is greatly reduced by halving the IC spread. By reducing the IC spread from 50% to 25% of the original magnitude, forecast spread is still substantially reduced in two of the three cases. The practical predictability limit (PPL), or the lead time beyond which the forecast spread exceeds some prechosen threshold, is case and feature dependent. Comparing to past studies reveals that practical predictability of supercells is substantially improved by initializing once storms are well established in the ensemble analysis.
Lack of consensus on optimal acetabular cup orientation because of variation in assessment methods in total hip arthroplasty: a systematic review
Authors: Snijders Thom E , Willemsen Koen , van Gaalen Steven M , Castelein Rene M , Weinans Harrie , de Gast Arthur 
Published: May 2018

Introduction: Dislocation is 1 of the main reasons for revision of total hip arthroplasty but dislocation rates have not changed in the past decades, compromising patients’ well-being. Acetabular cup orientation plays a key role in implant stability and has been widely studied. This article investigates whether there is a consensus on optimal cup orientation, which is necessary when using a navigation system. Methods: A systematic search of the literature in the PubMed, Embase and Cochrane databases was performed (March 2017) to identify articles that investigated the direct relationship between cup orientation and dislocation, including a thorough evaluation of postoperative cup orientation assessment methods. Results: 28 relevant articles evaluating a direct relation between dislocation and cup orientation could not come to a consensus. The key reason is a lack of uniformity in the assessment of cup orientation. Cup orientation is assessed with different imaging modalities, different methodologies, different definitions for inclination and anteversion, several reference planes and distinct patient positions. Conclusions: All available studies lack uniformity in cup orientation assessment; therefore it is impossible to reach consensus on optimal cup orientation. Using navigation systems for placement of the cup is inevitably flawed when using different definitions in the preoperative planning, peroperative placement and postoperative evaluation. Further methodological development is required to assess cup orientation. Consequently, the postoperative assessment should be uniform, thus differentiating between anterior and posterior dislocation, use the same definitions for inclination and anteversion with the same reference plane and with the patient in the same position.
The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire
Authors: Nauta Ilse M , Balk Lisanne J , Sonder Judith M , Hulst Hanneke E , Uitdehaag Bernard MJ , Fasotti Luciano , de Jong Brigit A 
Published: May 2018

Background: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS). Objective: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P). Methods: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses. Results: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition. Conclusion: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.
Evaluation of Cytotoxic and Genotoxic Effects of Extremely Low-frequency Electromagnetic Field on Mesenchymal Stromal Cells
Authors: Ross Christina L , Pettenati Mark J , Procita Joseph , Cathey Lisa , George Sunil K , Almeida-Porada Graca 
Published: May 2018

Background Interest in the use of extremely low-frequency (ELF) electromagnetic field (EMF) for the treatment of pain and inflammation is increasing due to the ability of this promising therapy to compete with pharmaceuticals without the adverse effects caused by drugs. However, there continues to be concerns regarding cytotoxic and genotoxic effects that may occur as a result of exposure to EMF. Objective To investigate this concern, we tested the effect of our known therapeutic 5 Hz, 0.4 milliTesla (mT) EMF on a human mesenchymal stromal cell (hMSC) line to determine whether ELF-EMF exposure would cause cytotoxic or genotoxic effects. Methods Treated samples along with controls were exposed to 5 Hz, 0.4 mT ELF-EMF for 20 min/day, 3×/week for 2 weeks and then assayed for cell viability, proliferation rates, and chromosome breaks. Results Cytogenetic analysis of the viability and proliferation rates along with analysis of morphological genome stability showed no cytotoxicity, and no chromosome breaks per karyotype analysis—therefore no genotoxicity. Conclusion Exposure to an ELF-EMF of 5 Hz, 0.4 mT for 20 min/day, 3×/week for 2 weeks does not cause cytotoxic or genotoxic effects in hMSCs.
Charles and Ray Eameses’ museums without walls: Films as exhibition and exhibitions as film
Authors: Ince Catherine 
Published: May 2018

Abstract
This article outlines the intersections between the exhibition and film work of Charles and Ray Eames and the Eames Office, and explores the ways in which film was used to create exhibition environments and vice versa. The Eameses’ desire to transmit ideas to the broadest public generated a concept of the ‘museum without walls’ that found its ultimate expression in the creation of large-scale multi-media and multi-sensory exhibition environments. Their influential practice pioneered new methods of immersive exhibition design, experimented with the use of film as inhabitable exhibit and also as a tool to capture and display cultural subjects and artefacts typically experienced in museum settings. Considering the Eameses’ projects afresh allows us to assess their role in shaping the expansive possibilities of film and the exhibition environment and the challenges of communicating ideas that continue to face museum professionals today.
The modern art of filmmaking: Architecture on-screen at MoMA
Authors: Collard Pete 
Published: May 2018

Abstract
The 1930s saw the Museum of Modern Art (MoMA) in New York become the first museum to include film within its exhibitions of architecture. Although other institutions had offered film screenings for visitors, what set MoMA apart was the manner in which the productions were presented, shown as exhibits within its galleries and displayed alongside photographic reproductions, architectural models and drawings as part of the curatorial narrative. Commissioned in an ad hoc fashion at times and produced to limited budgets, the films brought an emerging form of architectural representation to MoMA at a time when the cultural value of the cinema was still being debated. Under the leadership of Museum Director Alfred J. Barr Jr., the commissioning, curating and collecting of such works became part of a wider movement at MoMA to label the moving image as an art form in its own right.
Installing Islamic Art: Interior Space and Temporal Imagination
Authors: Kadoi Yuka 
Published: May 2018

Abstract
This special issue challenges the anachronistic image of Islamic art galleries that dominated the museum field worldwide during the twentieth century and seeks alternative modes of display to suit current sociopolitical circumstances. Entitled ‘Installing Islamic Art: Interior Space and Temporal Imagination’, the present issue gathers articles dealing with multifaceted topics that address the issue of display and curation of ‘Islamic art’. While the term itself requires further critical reassessment, each author offers an innovative approach and methodological proposition in an effort to recontextualize the current exhibitory trends in the public presentation of material remains from Muslim-majority societies, including the Arab lands, Iran, Turkey, and South Asia. Taken together, this collection of articles reveals many possibilities, rather than limitations, regarding how to thoughtfully showcase Muslim cultural heritage, representing a positive indication of future of curating Islamic art.
Islamic Occultism and the Museum
Authors: Leoni Francesca 
Published: May 2018

Abstract
The exhibition Power and Protection: Islamic Art and the Supernatural, held at the Ashmolean Museum, Oxford, between 20 October 2016 and 15 January 2017, provided the opportunity to reconsider some of the parameters employed in largescale Islamic art exhibitions. The subject of the show – select divinatory and amuletic practices, itself a break from more conventional themes – was explored by adopting a more inclusive and critical approach, drawing evidence from a wide social spectrum and transcending classifications of ‘ethnographic material’ and ‘fine art’. Attention was also given to daily practice, creating a fresh vantage point to reflect on the role and forms of devotion and broader notions of belief. While presenting practices and evidence that many might deem marginal (and that have certainly been marginalized over time), the exhibition ultimately offered a new analytical lens to challenge hierarchies of higher and lower culture, as well as sanctioned versus heterodox religious practices that continue to structure museum presentations and inform public perception of Islamic culture. By exploring the difficulties, achievements, and shortcomings of the project, and by incorporating insights from audience evaluations and impact questionnaires, this article reflects on the range of factors that shape today’s presentations of Islamic art and culture in the museum, as well as on the unprecedented challenges faced by specialists of Islam in western institutions at this critical historical moment. Furthermore, by considering the exhibition in the context of the current, revitalized museological interest in religions, it offers a contribution to the broader debate about religious objects in secular institutions and the need to reconcile multiple views and expectations.
Rockers, soulheads and lovers: Sound systems back in da day
Authors: McMillan Michael 
Published: May 2018

Abstract
This article explores the emergence of sound system culture in Britain, from post-war Caribbean migration to the early 1980s, in terms of House and Blues parties, clubs and dancehalls, bass culture, dance-floor corporeality, and raver’s sartorial aesthetics and interventions, with reference to oral history interviews with sound system pioneers, practitioners and ravers from my installation-based exhibition, Rockers, Soulheads & Lovers: Sound Systems Back in Da Day (New Art Exchange, Nottingham and 198 Contemporary Arts & Learning, London 2015–16).
Spatial and temporal distribution of Yunnan snub-nosed monkey, Rhinopithecus bieti, indices
Authors: Fu Rong , Li Li , Yu ZhongHua , Afonso Eve , Giraudoux Patrick 
Published: May 2018

Abstract
Studying elusive species of conservation concern might be difficult for technical and ethical reasons. However, censuses can be based on the observation of activity indices. When coupled to non-invasive genetic methods this approach can provide extremely precise information about population size, individual movements and diseases. However, the design of optimal sampling is dependent on a knowledge on group distribution and possible variations of detectability of index targets. The aim of this study was to document the distribution of Yunnan snub-nosed monkey indices in space and time in that perspective. Based on transects carried out across the range of a fed population and on counts along the trail across the range of a wild group, we show that 2–3 day stays of a group in a place of some hectares were sufficient to get an homogeneous distribution of indices. Furthermore, the number of indices found were dependent on both pig presence and season. On the other hand, on a large scale of 100 km2 indices were spatially distributed as nested clusters. Indices distribution indicated a strong preference towards southern slopes and altitudes ranging between 2900 and 3400 m. Those observations pinpoint the importance of considering spatial scale to organise sampling designed to estimate population distribution.