bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current targeted therapies in lymphomas
Authors: Chung Clement 
Published: October 2019

AbstractPurposeThis article summarizes current targeted therapies that have received regulatory approval for the treatment of B- and T-cell lymphomas.SummaryOver the last 20 years, new drug therapies for lymphomas of B cells and T cells have expanded considerably. Targeted therapies for B-cell lymphomas include: (1) monoclonal antibodies directed at the CD20 lymphocyte antigen, examples of which are rituximab, ofatumumab, and obinutuzumab; (2) gene transfer therapy, an example of which is chimeric antigen receptor–modified T-cell (CAR-T) therapy directed at the CD19 antigen expressed on the cell surface of both immature and mature B cells; and (3) small-molecule inhibitors (ibrutinib, acalabrutinib, copanlisib, duvelisib, and idelalisib) that target the B-cell receptor signaling pathway. Of note, brentuximab vedotin is an antibody–drug conjugate that targets CD30, another lymphocyte antigen expressed on the cell surface of both Hodgkin lymphoma (a variant of B-cell lymphoma) and some T-cell lymphomas. Although aberrant epigenetic signaling pathways are present in both B- and T-cell lymphomas, epigenetic inhibitors (examples include belinostat, vorinostat, and romidepsin) are currently approved by the Food and Drug Administration for T-cell lymphomas only. In addition, therapies that target the tumor microenvironment have been developed. Examples include mogamulizumab, bortezomib, lenalidomide, nivolumab, and pembrolizumab. In summary, the efficacy of these agents has led to the development of supportive care to mitigate adverse effects, due to the presence of on- or off-target toxicities.ConclusionThe therapeutic landscape of lymphomas has continued to evolve. In turn, the efficacy of these agents has led to the development of supportive care to mitigate adverse effects, due to the presence of on- or off-target toxicities. Further opportunities are warranted to identify patients who are most likely to achieve durable response and reduce the risk of disease progression. Ongoing trials with current and investigational agents may further elucidate their place in therapy and therapeutic benefits.
Tropical cyclones and the organization of mangrove forests: a review
Authors: Krauss Ken W , Osland Michael J 
Published: October 2019

AbstractBackgroundMany mangrove ecosystems are periodically exposed to high velocity winds and surge from tropical cyclones, and often recover with time and continue to provide numerous societal benefits in the wake of storm events.ScopeThis review focuses on the drivers and disturbance mechanisms (visible and functional) that tropical cyclones of various intensities have on mangrove ecosystem properties around the world, as well as the potential ecosystem services role offered by mangroves along storm-ravaged coastlines. When viewed together, studies describe repeatable types of impact and a variety of responses of mangroves that make them ecologically resilient to high velocity winds, and which have served to advance the notion that mangroves are disturbance-adapted ecosystems.ConclusionsStudies have documented massive tree mortality and forest structural shifts as well as high variability of spatial effects associated with proximity and direction of the tropical cyclone trajectory that influence biogeochemical processes, recovery of individual trees, and forest regeneration and succession. Mangroves provide coastal protection through surge and wind suppression during tropical cyclones, and yet are able to overcome wind effects and often recover unless some alternative environmental stress is at play (e.g. hydrological alteration or sedimentation). Structural elements of mangroves are influenced by the legacies imposed by past tropical cyclone injury, which affect their current appearance, and presumably their function, at any point in time. However, much is yet to be discovered about the importance of the effects of tropical cyclones on these fascinating botanical ecosystems, including the role of storm-based sediment subsidies, and much more effort will be needed to predict future recovery patterns as the frequency and intensity of tropical cyclones potentially change.
A cross-linguistic comparison of category verbal fluency test (ANIMALS): a systematic review
Authors: Ardila Alfredo 
Published: October 2019

AbstractBackgroundCross-linguistic information about performance in neuropsychological verbal tests is extremely scarce. It has been suggested that verbal fluency test using animal fluency test is one of the few tests fulfilling the fundamental criteria desirable in a robust neuropsychological test.ObjectiveTo compare and establish cross-linguistic information about performance in the animal fluency test.ResultsIn an extensive search, it was found that norms for the semantic fluency test using the category ANIMALS are available in 15 different languages. These languages represent a relatively broad spectrum of world languages, including not only Indo-European languages, but also Semitic, Sino-Tibetan, Austroasiatic, Dravidian, and even Amerindian languages. Normative data in these 15 languages are analyzed and the results are compared.ConclusionsIt is concluded that (a) pure linguistic factors, such as type of language and word-length, seemingly do not significantly affect the performance in this test; (b) two major demographic variables—age and education—account for a significant percentage of the variance in this test; the effect of sex seems to be neglectable; (c) in bilinguals, when the native language has few speakers and/or is a marginalized language, a very low score can be observed in the native language, even lower than in the second language; (d) there is a frequently overlooked major factor accounting for differences in cognitive test performance: the effort made in performing the test. It depends on the significance given to the test performance. Effort is quite variable across cultures and is higher in psychometric-oriented societies.
Hawkmoth pollination of the orchid Habenaria clavata: mechanical wing guides, floral scent and electroantennography
Authors: Johnson Steven D , Balducci Marco G , Shuttleworth Adam 
Published: October 2019

AbstractFloral morphology can play a key role in mechanically guiding pollinators towards reproductive structures, particularly when visibility is limited at night, but the functional significance of morphological traits has seldom been considered in this context. Here we describe a remarkably intricate pollination mechanism in the hawkmoth-pollinated African grassland orchid Habenaria clavata, and also document aspects of the reproductive success and chemical ecology of this pollination system. The flowers are pollinated by several short-tongued hawkmoths, particularly Basiothia schenki, which was the most frequent visitor and occurred at all sites. Moths are probably attracted by the strong scent, which was dominated by several oxygenated aromatics that also elicited strong electrophysiological responses from antennae of B. schenki. Apart from the white rostellum lobes and stigma, which serve as a visual guide to the spur entrance, the flower parts are entirely green and indistinguishable from leaves in terms of spectral information. Using motion-activated video cameras we established that the leading edges of the forewings of foraging hawkmoths contact the two upwardly curving petal lobes, and that hawkmoths are then apparently mechanically guided down onto the reproductive structures. Pollinaria are attached in an unusual place – among hairs on the ventral surface of the thorax, between the middle legs – and are brushed over the protruding stigma lobes when the proboscis is fully inserted in the 41-mm-long spur. These results highlight how multiple traits (morphology, spectral reflectance and scent) can act synergistically to ensure transfer of pollen among flowers.
Covariates of Burnout and Secondary Traumatisation in Professionals Working with Child Survivors of Trauma: A Research Synthesis
Authors: Vang Maria L , Gleeson Christina , Hansen Maj , Shevlin Mark 
Published: October 2019

Abstract
It has been demonstrated that working with trauma-exposed children increases the risk for developing secondary traumatisation (ST) and burnout (BO). High correlations between ST and BO have been reported, suggesting an empirical overlap between the constructs. The purpose of the present review was to synthesise research investigating covariates of BO and ST to explore whether this overlap extends to covariates. Seven research databases were searched for studies investigating covariates of both BO and ST. Identified studies were screened in accordance with predefined inclusion and exclusion criteria, resulting in thirteen articles being included for further review. Fourteen covariates were examined in two or more of the included studies and were synthesised according to the ‘levels of evidence approach’. Some individual and operational factors appeared to be equally related to BO and ST. There was a predominance of equivocal evidence for and against the salience of different covariates as well as an over-representation of demographic factors compared to organisational and operational factors in the current literature. More research investigating the nature of the overlap between BO and ST is needed, and future research would benefit from integrating covariates supported in the work and organisational literature with covariates from the psychotraumatological literature.
Push and pull of downstream moving juvenile sea lamprey (Petromyzon marinus) exposed to chemosensory and light cues
Authors: Johnson Nicholas S , Miehls Scott M , Haro Alex J , Wagner C Michael 
Published: October 2019

AbstractVisual and olfactory stimuli induce behavioural responses in fishes when applied independently, but little is known about how simultaneous exposure influences behaviour, especially in downstream migrating fishes. Here, downstream moving juvenile sea lamprey (Petromyzon marinus) were exposed to light and a conspecific chemosensory alarm cue in a flume and movement were monitored with overhead cameras and nets. When exposed to light, sea lamprey were more likely to be captured in a net closest to the light array. When exposed to the alarm cue, sea lamprey transit rate through the flume increased, but sea lamprey did not avoid the alarm cue plume by moving perpendicular to flow. When the alarm cue and light were applied simultaneously in a push and pull configuration, the alarm cue still triggered enhanced downstream movement (push downstream) and more sea lamprey was still captured in the net nearest the light (pull to the side), resulting in twice as many sea lamprey being captured in the lighted net relative to controls. To our knowledge, this is the first study using multiple sensory cues in a push-pull configuration to modulate fish outmigration. Push and pull of juvenile sea lamprey with sensory cues could be useful to reduce turbine entrainment where native and enhance trap catch where invasive.
Financial Trouble Across Generations: Evidence from the Universe of Personal Loans in Denmark
Authors: Kreiner Claus Thustrup , Leth-Petersen Søren , Willerslev-Olsen Louise Charlotte 
Published: October 2019

Abstract
This article uses administrative data with longitudinal information about defaults for the entire Danish population to analyse the driving forces behind financial problems. Non-parametric evidence shows that the default propensity is more than four times higher for individuals with parents in default compared with that for individuals with parents not in default. This intergenerational relationship is apparent soon after children move into adulthood and become legally able to borrow, and is remarkably stable across parental income levels, childhood school performances, levels of loan balances and time periods. The evidence indicates that inherited financial behaviour is important for explaining differences in financial trouble.
Mini-extracorporeal circulation surgery produces less inflammation than off-pump coronary surgery
Authors: Permanyer Eduard , Munoz-Guijosa Christian , Padró Josep-Maria , Ginel Antonino , Montiel José , Sánchez-Quesada José Luis , Vila Luis , Camacho Mercedes 
Published: October 2019

AbstractOBJECTIVESBoth off-pump coronary artery bypass grafting surgery (OPCABG) and mini-extracorporeal circulation (MECC) have been associated with lower morbidity and mortality and less inflammation than conventional cardiopulmonary bypass. However, studies comparing the 2 techniques are scarce and the results are controversial. We compared the clinical outcomes and inflammatory response of low-risk patients undergoing coronary bypass grafting with MECC versus OPCABG.METHODSWe conducted a prospective, randomized study in patients undergoing coronary heart surgery. Two hundred and thirty consecutive low-risk patients were randomly assigned to either receive OPCABG (n = 117) or MECC (n = 113). Clinical outcomes and postoperative biochemical results were analysed in both groups. We also analysed 19 circulating inflammatory markers in a subgroup of 40 patients at 4 perioperative time points. The area under the curve for each marker was calculated to monitor differences in the inflammatory response.RESULTSNo significant differences were found between groups regarding perioperative clinical complications and no deaths occurred during the trial. Plasma levels in 9 of the 19 inflammatory markers were undetectable or showed no temporal variation, 3 were higher in the MECC group [interleukin (IL)-10, macrophage inflammatory protein-1β and epidermal growth factor] and 7 were higher in the OPCABG group (growth regulator oncogene, IL-6, IL-8, soluble CD40 ligand, monocyte chemoattractant protein-1, monocyte chemoattractant protein-3 and tumour necrosis factor-α). Differences in 2 proinflammatory cytokines, IL-6 and monocyte chemoattractant protein 1, between the 2 surgical procedures were statistically significant.CONCLUSIONSNo clinical differences were observed between in low-risk patients undergoing MECC or OPCABG surgery, but OPCABG was associated with an increased release of proinflammatory cytokines compared with MECC. Studies in larger cohorts and in patients at higher risk are needed to confirm these findings.Clinical trial registration numberNCT02118025.
The effect of the 2008 recession on well-being and employment status of people with and without mental health problems
Authors: Jónsdóttir Unnur , þórðardóttir Edda Björk , Aspelund Thor , Jónmundsson þórarinn , Einarsdóttir Kristjana 
Published: October 2019

Abstract

Background
The world was hit hard by the 2008 recession which led to increased unemployment and financial strain. However, how the recession affected people with pre-existing mental health problems has been understudied. This study investigates the effect of the 2008 recession in Iceland on stress, well-being and employment status of people with regard to whether they are suffering from mental health problems.

Methods
The study cohort included participants (18–69 years old) of the ‘Health and Wellbeing of Icelanders’, a 3-wave survey conducted before (in 2007) and after (in 2009 and 2012) the recession in 2008. Self-assessed well-being was measured with the Short Warwick-Edinburgh Mental Well-being Scale and the 4-item Perceived Stress Scale. Logistic regression was used to assess the effect of the 2008 recession on self-assessed well-being and employment status in 2009 and 2012, using 2007 as a reference year.

Results
Participants with no pre-recession mental health problems were at increased risk of both poor well-being, (with adjusted odds ratio at 1.66, in 2009 and 1.64 in 2012) and higher perceived stress, (with adjusted odds ratio at 1.48 in 2009 and 1.53 in 2012), after the recession. Interestingly, no significant change in well-being and perceived stress was observed among participants suffering from pre-recession mental health problems. Both groups had increased risk of unemployment after the recession.

Conclusion
Results indicate that after recessions, the risk of stress and poor well-being increases only among those who do not suffer from pre-recession mental health problems.
The invasive ACGW Dryocosmus kuriphilus (Hymenoptera: Cynipidae) in Spain: native parasitoid recruitment and association with oak gall inducers in Catalonia
Authors: Jara-Chiquito Juan Luis , Askew Richard R , Pujade-Villar Juli 
Published: October 2019

AbstractThe Asian chestnut gall wasp (ACGW), Dryocosmus kuriphilus (Hymenoptera: Cynipidae), is an invasive pest that affects chestnut trees. The first record of this pest in Spain was in 2012, in Catalonia, and it is now distributed in virtually every chestnut growing area in the country. In this study, we present an overview of parasitoid recruitment by ACGW in Catalonia over a 4-year period (2013–2016) comparing parasitoid communities attacking galls on oak and chestnut trees at the same sites. A total of 22 species of native parasitoids that normally attack oak cynipids emerged from ACGW galls, together with the non-native Torymus sinensis. The most abundant species were Bootanomyia dorsalis, Torymus flavipes, Ormyrus pomaceus and Eupelmus urozonus. The study also found that 20 of the 22 native parasitoids in ACGW galls were also reared from galls of 13 species of oak gall inducer (12 Cynipidae, 1 Cecidomyiidae).
Impact of Mutation Rate and Selection at Linked Sites on DNA Variation across the Genomes of Humans and Other Homininae
Authors: Castellano David , Eyre-Walker Adam , Munch Kasper 
Published: October 2019

AbstractDNA diversity varies across the genome of many species. Variation in diversity across a genome might arise from regional variation in the mutation rate, variation in the intensity and mode of natural selection, and regional variation in the recombination rate. We show that both noncoding and nonsynonymous diversity are positively correlated to a measure of the mutation rate and the recombination rate and negatively correlated to the density of conserved sequences in 50 kb windows across the genomes of humans and nonhuman homininae. Interestingly, we find that although noncoding diversity is equally affected by these three genomic variables, nonsynonymous diversity is mostly dominated by the density of conserved sequences. The positive correlation between diversity and our measure of the mutation rate seems to be largely a direct consequence of regions with higher mutation rates having more diversity. However, the positive correlation with recombination rate and the negative correlation with the density of conserved sequences suggest that selection at linked sites also affect levels of diversity. This is supported by the observation that the ratio of the number of nonsynonymous to noncoding polymorphisms is negatively correlated to a measure of the effective population size across the genome. We show these patterns persist even when we restrict our analysis to GC-conservative mutations, demonstrating that the patterns are not driven by GC biased gene conversion. In conclusion, our comparative analyses describe how recombination rate, gene density, and mutation rate interact to produce the patterns of DNA diversity that we observe along the hominine genomes.
Older Adults’ Self-Perceptions of Aging and Being Older: A Scoping Review
Authors: Hausknecht Simone , Low Lee-Fay , O’Loughlin Kate , McNab Justin , Clemson Lindy 
Published: October 2019

Abstract

Background and Objectives
Older adults’ self-perceptions of aging and being older can influence well-being and quality of life. This systematic scoping review aimed to map out current research on older adults’ self-perceptions of aging and being older.

Research Design and Methods
The scoping review followed Arksey and O’Malley’s methodological framework. A total of 5,037 records were identified (duplicates removed). After screening, a final 148 papers were included. Descriptives, including year of publication, methodology, age, gender, and location of participants, were calculated. Thematic analyses were conducted examining ways in which the topic was conceptualized.

Results
The most frequent method used in the research was quantitative. Participants were from 38 different countries. There were more female participants than male. Seven themes representing the main research emphasis emerged: attitudes towards one’s own aging (n = 48), aging well (n = 23), aging stereotypes, self-stigma (n = 23), construction of aging identities (n = 22), subjective age (n = 18), the aging body (n = 8), and future self-views (n = 6).

Discussion and Implications
The research within these themes approach self-perceptions of aging using varying points of reference for what participants compare their age to. The methods used to illicit aging perspectives held their own assumptions about aging.
Evidencing the relationship between injected volume of water and maximum expected magnitude during the Puerto Gaitán (Colombia) earthquake sequence from 2013 to 2015
Authors: Gómez Alba Sebastián , Vargas Carlos A , Zang Arno 
Published: October 2019

ABSTRACTSince 2013 to date more than 1000 seismic events have been recorded by the Servicio Geologico Colombiano (Colombian Geological Survey, SGC) in the municipality of Puerto Gaitán (Colombia). A total of 14 earthquakes are moment magnitude Mw > 4.0. The largest event ever recorded in the area occurred in November 2015 with Mw 4.8. It seems like the case of Puerto Gaitán is associated with the deep injection of coproduced wastewater from oil and gas extraction. The data presented in this work suggests a close relationship in space and time between injection operations and seismicity. An analysis of temporality between both data sets resulted in a time lag equivalent to about 218 d. For this paper, we computed the input and output energy during injection operations from 2013 to 2015 in order to estimate the fraction of total input energy that is radiated as seismic waves. Our results suggest that the seismic energy is only a small fraction of the total energy into the system. Although Puerto Gaitan is one of the places with the most significant volume of wastewater injected among the ones reported in the literature, the energy efficiency of the system is the lowest reported to date in comparison with other applied technologies. The low efficiency seems to be associated to the aseismic deformation of the reservoir rocks. The observed clustering of earthquakes is delimited by the basement crystalline depth. From an operational point of view, we determine that, like most cases associated with fluid injection, volume of fluid is the variable that determines change in the seismic moment released. Furthermore, the sequence of events in Puerto Gaitán may not fit into a well-known correlation between the volume of fluid injected and the maximum expected magnitude. The observed magnitudes in Puerto Gaitan are well bellow compared to those reported in the literature for similar volumes of injected fluid.
Using Conceptual Metaphors to Represent Temporal Context in Time Series Data Sonification
Authors: Roddy Stephen 
Published: October 2019

Abstract
This article explores how conceptual metaphor theory can be applied to the problem of representing temporal context in the sonification of time series data. It opens with an introduction to some of the conceptual metaphors involved in our understanding of time and music. Two of these metaphors are extended to the domain of Auditory Display and act as a guide to the creation of a design framework for representing temporal context in the sonification of time series data. An empirical listener evaluation of this framework is then presented and the results analysed to gauge the efficacy of this approach. The results suggest that the framework supports the listener, to a limited degree, in estimating which time-point they are currently hearing, how many time-points they have already heard and how many time-points they have left to hear. Improvements to the framework are suggested, and plans for future iterations are discussed.