bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preconception prediction of expectant fathers' mental health: 20-year cohort study from adolescence
Authors: Spry Elizabeth , Giallo Rebecca , Moreno-Betancur Margarita , Macdonald Jacqui , Becker Denise , Borschmann Rohan , Brown Stephanie , Patton George C. , Olsson Craig A. 
Published: March 2018

We examined prospective associations between men's common mental disorders in the decades prior to offspring conception and subsequent paternal antenatal mental health problems. Data came from a prospective intergenerational cohort study which assessed common mental disorder nine times from age 14 to 29 years, and in the third trimester of subsequent pregnancies to age 35 years (N = 295 pregnancies to 214 men). Men with histories of adolescent and young adult common mental disorders were over four times more likely to experience antenatal mental health problems. Future research identifying modifiable perinatal factors that counteract preconception risk would provide further targets for intervention.Declaration of interestNone.
Risk of suicide attempts in adolescents and young adults with attention-deficit hyperactivity disorder: a nationwide longitudinal study
Authors: Huang Kai-Lin , Wei Han-Ting , Hsu Ju-Wei , Bai Ya-Mei , Su Tung-Ping , Li Cheng-Ta , Lin Wei-Chen , Tsai Shih-Jen , Chang Wen-Han , Chen Tzeng-Ji , Chen Mu-Hong 
Published: March 2018

BackgroundAttention-deficit hyperactivity disorder (ADHD) increases the risk of suicidal behaviours through psychiatric comorbidities; however, a significant direct association has not been observed between ADHD and suicide attempts.AimsTo evaluate the risk of suicide attempt in adolescents and young adults with ADHD.MethodUsing a nationwide, population-based insurance claims database, this longitudinal cohort study enrolled 20 574 adolescents and young adults with ADHD and 61 722 age- and gender-matched controls between 2001 and 2009. Any suicide attempt was identified from enrolment to 31 December 2011. The association between ADHD medications and the likelihood of suicide attempt was assessed.ResultsADHD was an independent risk factor for any suicide attempt (hazard ratio = 3.84, 95% CI = 3.19–4.62) and repeated suicide attempts (hazard ratio = 6.52, 95% CI = 4.46–9.53). Subgroup analyses of men, women, adolescents and young adults demonstrated the same trend. Methylphenidate or atomoxetine treatment did not increase the risk of suicide attempt or repeated suicide attempts. Long-term methylphenidate treatment was associated with a significantly decreased risk of repeated suicide attempts in men (hazard ratio = 0.46, 95% CI = 0.22–0.97).ConclusionADHD was a risk factor for suicide attempt and a stronger predictor of repeated suicide attempts, independent of comorbidities. Further investigation is warranted to explore the mechanism underlying the association between ADHD and suicidal behaviours.Declaration of interestNone.
The Association Between Timing of Routine Preoperative Blood Testing and a Composite of 30-Day Postoperative Morbidity and Mortality
Authors: Ruetzler Kurt , Lin Peirong , You Jing , Schacham Yehoshua , Naylor Amanda J. , Sessler Daniel I. , Saager Leif 
Published: March 2018

BACKGROUND:
Laboratory testing is a common component of preanesthesia evaluation and is designed to identify medical abnormalities that might otherwise remain undetected. While blood testing might optimally be performed shortly before surgery, it is often done earlier for practical reasons. We tested the hypothesis that longer periods between preoperative laboratory testing and surgery are associated with increased odds of having a composite of 30-day morbidity and mortality.

METHODS:
We obtained preoperative data from 2,320,920 patients in the American College of Surgeons National Surgical Quality Improvement Program who were treated between 2005 and 2012. Our analysis was restricted to relatively healthy patients with American Society of Anesthesiology physical status I–II who had elective surgery and normal blood test results (n = 235,010). The primary relationship of interest was the odds of 30-day morbidity and mortality as a function of delay between preoperative testing and surgery. A multivariable logistic regression model was used for the 10 pairwise comparisons among the 5 laboratory timing groups (laboratory blood tests within 1 week of surgery; 1–2 weeks; 2–4 weeks; 1–2 months; and 2–3 months) on 30-day morbidity, adjusting for any imbalanced baseline covariables and type of surgery.

RESULTS:
A total of 4082 patients (1.74%) had at least one of the component morbidities or died within 30-days after surgery. The observed incidence (unadjusted) was 1.7% when the most recent laboratory blood tests measured within 1 week of surgery, 1.7% when it was within 1–2 weeks, 1.8% when it was within 2–4 weeks, 1.7% when it was between 1 and 2 months, and 2.0% for patients with most recent laboratory blood tests measured 2–3 months before surgery. None of the values within 2 months differed significantly: estimated odds ratios for patients within blood tested within 1 week were 1.00 (99.5% confidence interval, 0.89–1.12) as compared to 1–2 weeks, 0.88 (0.77–1.00) for 2–4 weeks, and 0.95 (0.79–1.14) for 1–2 months, respectively. The estimated odds ratio comparing 1–2 weeks to each of 2–4 weeks and 1–2 months were 0.88 (0.76–1.03) and 0.95 (0.78–1.16), respectively. Blood testing 2–3 months before surgery was associated with increased odds of outcome compared to patients whose most recent test was within 1 week (P = .002) and 1–2 weeks of the date of surgery.

CONCLUSIONS:
In American Society of Anesthesiologists physical status I and II patients, risk of 30-day morbidity and mortality was not different with blood testing up to 2 months before surgery, suggesting that it is unnecessary to retest patients shortly before surgery.
The Association of Targeted Cell Salvage Blood Transfusion During Cesarean Delivery With Allogeneic Packed Red Blood Cell Transfusions in a Maternity Hospital in China
Authors: Yan Haiya , Hu Ling-Qun , Wu Yun , Fan Qihui , Wong Cynthia A. , McCarthy Robert J. 
Published: March 2018

BACKGROUND:
Autologous transfusion of intraoperative cell salvage blood may be a potential method to decrease the need for allogeneic packed red blood cell transfusions after cesarean delivery, although there are limited data on the benefits of this method. This study evaluated the implementation of targeted intraoperative cell salvage during cesarean delivery in women at increased risk for hemorrhage at the Women’s and Children’s Hospital in Ningbo, China.

METHODS:
All women who underwent cesarean delivery >28 weeks of gestation were included in the study. The period before intraoperative cell collection (October 1, 2010, to August 31, 2012, n = 11,322) was compared with the postimplementation period (September 1, 2012, to June 30, 2015, n = 17,456) using an interrupted time series analysis. In the postimplementation period, women suspected to be at increased risk of the need for a blood transfusion (1604, 9.2%) underwent intraoperative cell salvage collection. The primary outcomes were the monthly rate of allogeneic packed red blood cell use and the incidence of clinical manifestation of acute blood transfusion reactions.

RESULTS:
The mean (standard deviation) estimated monthly allogeneic packed blood cell transfusion rate at the end of the 57-month study was 2.2% ± 0.7% with the implementation compared with 2.7% ± 0.9% without, difference −0.5%, 95% CI, −1.4% to 0.3%; P = .22. The mean number of allogeneic units transfused per patient was 4.1 ± 0.4 units with implementation and 3.9 ± 0.9 units without, difference 0.2, 95% CI, −1.7 to 1.1 units; P = .69. Intraoperative cell salvage blood was reinfused in 757 (47%) and wasted in 847 (53%) cases. The monthly intraoperative allogeneic packed red blood cells use rate was lower after implementation (difference −0.7%, 95% CI, −0.1% to −1.4%; P = .03); however, the monthly postpartum allogeneic packed red blood cell use rate was unchanged (difference −0.2%, 95% CI, −0.4% to 0.7%; P = .56). The clinical manifestation of acute blood transfusion reactions rate was unchanged (difference −2%, 99% CI, −9% to 5%; P = .55) between the periods.

CONCLUSIONS:
Our findings suggest that targeted intraoperative cell salvage in women undergoing cesarean delivery was associated with less allogeneic blood exposure in the operating room, but not in the postoperative period. Intraoperative cell salvage in targeted cesarean deliveries was not associated with a lesser allogeneic red blood cell exposure over the hospital admission period. The lack of adverse events associated with intraoperative cell salvage supports the safety of intraoperative cell salvage in cesarean delivery.
A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range
Authors: Nachman Einav , Clemensen Peter , Santos Katheryn , Cole Alexis R. , Polizzotti Brian D. , Hofmann Grace , Leeman Kristen T. , van den Bosch Sarah J. , Kheir John N. 
Published: March 2018

BACKGROUND:
The accurate measurement of oxygen consumption (VO2) and energy expenditure (EE) may be helpful to optimize the treatment of critically ill patients. However, current techniques are limited in their ability to accurately quantify these end points in infants due to a low VO2, low tidal volume, and rapid respiratory rate. This study describes and validates a new device intended to perform in this size range.

METHODS:
We created a customized device that quantifies inspiratory volume using a pneumotachometer and concentrations of oxygen and carbon dioxide gas in the inspiratory and expiratory limbs. We created a customized algorithm to achieve precise time alignment of these measures, incorporating bias flow and compliance factors. The device was validated in 3 ways. First, we infused a certified gas mixture (50% oxygen/50% carbon dioxide) into an artificial lung circuit, comparing measured with simulated VO2 and carbon dioxide production (VCO2) within a matrix of varying tidal volume (4–20 mL), respiratory rate (20–80 bpm), and fraction of inspired oxygen (0.21–0.8). Second, VO2, VCO2, and EE were measured in Sprague Dawley rats under mechanical ventilation and were compared to simultaneous Douglas bag collections. Third, the device was studied on n = 14 intubated, spontaneously breathing neonates and infants, comparing measured values to Douglas measurements. In all cases, we assessed for difference between the device and reference standard by linear regression and Bland–Altman analysis.

RESULTS:
In vitro, the mean ± standard deviation difference between the measured and reference standard VO2 was +0.04 ± 1.10 (95% limits of agreement, −2.11 to +2.20) mL/min and VCO2 was +0.26 ± 0.31 (−0.36 to +0.89) mL/min; differences were similar at each respiratory rate and tidal volume measured, but higher at fraction of inspired oxygen of 0.8 than at 0.7 or lower. In rodents, the mean difference was −0.20 ± 0.55 (−1.28 to +0.89) mL/min for VO2, +0.16 ± 0.25 (−0.32 to +0.65) mL/min for VCO2, and −0.84 ± 3.29 (−7.30 to +5.61) kcal/d for EE. In infants, the mean VO2 was 9.0 ± 2.5 mL/kg/min by Douglas method and was accurately measured by the device (bias, +0.22 ± 0.87 [−1.49 to +1.93] mL/kg/min). The average VCO2 was 8.1 ± 2.3 mL/kg/min, and the device exhibited a bias of +0.33 ± 0.82 (−1.27 to +1.94) mL/kg/min. Mean bias was +2.56% ± 11.60% of the reading for VO2 and +4.25% ± 11.20% of the reading for VCO2; among 56 replicates, 6 measurements fell outside of the 20% error range, and no patient had >1 of 4 replicates with a >20% error in either VO2 or VCO2.

CONCLUSIONS:
This device can measure VO2, VCO2, and EE with sufficient accuracy for clinical decision-making within the neonatal and pediatric size range, including in the setting of tachypnea or hyperoxia.
Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9
Authors: Goto Hiroki , Nishio Miki , To Yoko , Oishi Tatsuya , Miyachi Yosuke , Maehama Tomohiko , Nishina Hiroshi , Akiyama Haruhiko , Mak Tak Wah , Makii Yuma , Saito Taku , Yasoda Akihiro , Tsumaki Noriyuki , Suzuki Akira 
Published: March 2018

ABSTRACT
Hippo signaling is modulated in response to cell density, external mechanical forces, and rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor proteins are core components of Hippo signaling and influence Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which are potent transcriptional regulators. YAP1/TAZ are key contributors to cartilage and bone development but the molecular mechanisms by which the Hippo pathway controls chondrogenesis are largely unknown. Cartilage is rich in ECM and also subject to strong external forces – two upstream factors regulating Hippo signaling. Chondrogenesis and endochondral ossification are tightly controlled by growth factors, morphogens, hormones, and transcriptional factors that engage in crosstalk with Hippo-YAP1/TAZ signaling. Here, we generated tamoxifen-inducible, chondrocyte-specific Mob1a/b-deficient mice and show that hyperactivation of endogenous YAP1/TAZ impairs chondrocyte proliferation and differentiation/maturation, leading to chondrodysplasia. These defects were linked to suppression of SOX9, a master regulator of chondrogenesis, the expression of which is mediated by TEAD transcription factors. Our data indicate that a MOB1-dependent YAP1/TAZ-TEAD complex functions as a transcriptional repressor of SOX9 and thereby negatively regulates chondrogenesis.
Genome-wide strategies identify downstream target genes of chick connective tissue-associated transcription factors
Authors: Orgeur Mickael , Martens Marvin , Leonte Georgeta , Nassari Sonya , Bonnin Marie-Ange , Börno Stefan T. , Timmermann Bernd , Hecht Jochen , Duprez Delphine , Stricker Sigmar 
Published: March 2018

ABSTRACT
Connective tissues support organs and play crucial roles in development, homeostasis and fibrosis, yet our understanding of their formation is still limited. To gain insight into the molecular mechanisms of connective tissue specification, we selected five zinc-finger transcription factors – OSR1, OSR2, EGR1, KLF2 and KLF4 – based on their expression patterns and/or known involvement in connective tissue subtype differentiation. RNA-seq and ChIP-seq profiling of chick limb micromass cultures revealed a set of common genes regulated by all five transcription factors, which we describe as a connective tissue core expression set. This common core was enriched with genes associated with axon guidance and myofibroblast signature, including fibrosis-related genes. In addition, each transcription factor regulated a specific set of signalling molecules and extracellular matrix components. This suggests a concept whereby local molecular niches can be created by the expression of specific transcription factors impinging on the specification of local microenvironments. The regulatory network established here identifies common and distinct molecular signatures of limb connective tissue subtypes, provides novel insight into the signalling pathways governing connective tissue specification, and serves as a resource for connective tissue development.
Pure Organic Conductors Based on Protonic-Defect Induction: From Semiconductors to Organic Metals
Authors: Kobayashi Yuka 
Published: March 2018

Abstract
Protonic defects function as “lost positive point charges”, and their inclusion in molecules has great potential to control the total charge of a system. In other words, they have the ability to work as a dopant for hole injection. Carrier generation occurs when we confine and stabilize the protonic defects in hydrogen-bonding networks co-existing with a tetrathiafulvalene (TTF) skeleton, affording pure organic conductors without an addition of external dopant or electrochemical oxidation. Their conductivity varies in the range of six orders of magnitude from 10−4 to 102 S/cm, corresponding to molecular design. Moreover, anomalous isotope effects are observed in some electronic properties such as conductivity and thermopower, etc. In this account, the concept, molecular design, carrier generation and electronic properties of a series of the protonic-defect induced pure organic conductors are comprehensively reviewed from semiconductors to organic metals.
ДИНАМИКА КЛИНИКО-ИММУНОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ ОСТРОГО НЕЛИМФОБЛАСТНОГО ЛЕЙКОЗА
Authors: Smirnova Olga Valentinovna , Manchuk Valery Timofeevich 
Published: March 2018

Целью исследования было изучение особенностей клинических проявлений, иммунопатогенеза и механизмов нарушения метаболического статуса лимфоцитов у больных острым миелобластным лейкозом (ОМЛ). На стадии острого дебюта и ремиссии ОМЛ развивается Т-клеточный иммунодефицит, на стадии повторного рецидива – комбинированный иммунодефицит с поражением Т- и В-систем иммунитета. Особенностью ОМЛ является истощение содержания NK-клеток, которое способствует прогрессированию заболевания и развитию рецидива. На всех стадиях ОМЛ наблюдается выраженное уменьшение интенсивности внутриклеточных метаболических процессов лимфоцитов, снижаются митохондриальный транспорт, гликолиз, метаболизм в лимонном цикле. Особенностью острого дебюта и ремиссии ОМЛ является снижение перекисных процессов в лимфоцитах. При повторном рецидиве – восстанавливаются перекисные процессы в лимфоцитах, однако, снижается внутриклеточный липидный катаболизм.
A study with regard to the effect of sport on social values<p>Sporun toplumsal değerler üzerindeki etkisi hakkında bir çalışma
Authors: Abanoz Engin Işık , Soyer Fikret 
Published: March 2018

This work deals with the relationship between social values and sociological function of sport which is a social issue with all its aspects. Sport, both affects and being affected by social structure and processes. In this respect, this work aims to discuss current situation about the relationship between sport and socialvalues. This discussion is starts with the sport’s role on the production of moral values and then focuses a breakthrough which occured at sport’s affects on social values. Accordingly, industrialization of sport, brings with it the aim of win as an highest value. This position of the aim of win, exulcerated sport’s moral values, especially fair play. Therefore, according to this work’s claim, socail values being affected in a bad manner by sport activities.Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetBu çalışmada, her yönüyle toplumsal bir mesele olan sporun sosyolojik işlevinin toplumsal değerlerle ilişkisi konu edilmektedir. Bu bağlamda, toplumsal yapı ve süreçlerden etkilendiği kadar toplumun üzerinde de etkili olan sporun toplumsal değerler ile olan ilişkisinde günümüzde hangi noktada olduğunu tartışmak amaçlanmaktadır. Sporun ahlâki değerlerin üretiminde nasıl bir rol oynadığı ve oynayabileceği ile başlatılan söz konusu tartışma, sporun toplumsal değerler üzerindeki etkisinde yaşanan bir kırılmaya odaklanmaktadır. Buna göre sporun endüstriyelleşmesi, kazanma hedefinin en üst değer olmasını beraberinde getirmiştir. Kazanmanın bu konuma gelmesi, fair play başta olmak üzere spordaki ahlâki değerlerin hemen hepsini aşındırmış ve bu durum da toplumdaki değerleri olumsuz yönde etkilemektedir.
Development of self compassion of hearing impaired students with the activities based on works of art<p>İşitme engelli öğrencilerin öz duyarlıklarının sanat yapıtlarına dayalı etkinlikler ile geliştirilmesi
Authors: Ural Berfin , Çakır İlhan Ayşe 
Published: March 2018

This study was conducted in order to develop the self-compassion of hearing impaired students via activities organized with works of art. 24 students in total who study at 9th, 10th and 11th classes of Private Education Public Vocational High School in Altındağ, Ankara which is under the body of the Ministry of National Education participated in the study. 8 week 90 minutes activity program was applied. In order to measure the self-compassion of the students “Self-compassion Scale for Hearing Impaired” was developed. “Self-compassion Scale for Hearing Impaired” and “Personal Information Form” (pre-test) were applied to experimental and control group after the activities of the experimental group finished (post-test), one month after the study was completed (follow-up test). In this study, pre-test and post-test control group model which is one of the real experiment models was used. The relation between self-compassion was examined in accordance with the study aims. It was determined as a result of the study that self-compassion of the students in the experimental group was improved. It was specified as a result of the analysis that self-compassion development was in favour of the experimental group. Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetBu çalışma, işitme engelli öğrencilerin sanat yapıtları ile düzenlenmiş etkinlikler yolu ile öz duyarlıklarını geliştirmek amacıyla yapılmıştır. Çalışmaya Ankara Altındağ Kemal Yurtbilir Özel Eğitim Meslek Lisesi’nde 9., 10. ve 11. sınıflara devam eden toplam 24 öğrenci katılmıştır. Çalışmaya 15-21 yaş arası işitme engelli gençler katılmıştır. 8 haftalık 90 dakikalık etkinlik programı uygulanmıştır. Öğrencilerin öz duyarlıklarını ölçmek için “İşitme Engelliler İçin öz Duyarlık Ölçeği” geliştirilmiştir. “İşitme Engelliler İçin Öz Duyarlık Ölçeği” ve “Kişisel Bilgi Formu” (ön-test), deney grubunun uygulamaları bittikten sonra (son test), çalışma tamamlandıktan bir ay sonra deney ve kontrol grubuna (izleme testi) uygulanmıştır. Bu çalışmada gerçek deneme modellerinden birisi olan öntest ve sontest kontrol gruplu model kullanılmıştır. Araştırma amaçları doğrultusunda öz duyarlık arasındaki ilişki incelenmiştir. Araştırma sonucunda deney grubunda ki öğrencilerinin öz duyarlık düzeyinin gelişmiş olduğu saptanmıştır. Yapılan analizler sonucunda öz duyarlık gelişimi deney grubu lehine olumlu olarak geliştiği tespit edilmiştir.
Transitions from Pits to Cracks during Stress Corrosion Cracking in a Low-Carbon Steel
Authors: Kolawole S. K. , Obayemi J. D. , Kolawole F. O. , Soboyejo A. B. O. , Soboyejo W. O. 
Published: March 2018

Abstract
This article presents the results of a combined experimental and analytical/computational study of the transition from corrosion pits to stress corrosion cracks during the exposure of low-carbon steel to environments with different pH levels (pH of 3, 5, 8, and 11). The transition from pits to cracks is elucidated via confocal microscopy and scanning electron microscopy. The stress concentrations associated with possible pit sizes and configurations are also modeled using finite element analyses and fracture mechanics models. Finally, the implications of the results are discussed for the modeling of the transition from pitting to stress corrosion cracking in low-carbon steels.
Circulação das ideias e internacionalização da Educação Superior: inferências a partir da teoria dos campos de Pierre Bourdieu
Authors: Azevedo Mário Luiz Neves de , Catani Afrânio Mendes , Hey Ana Paula 
Published: March 2018

A partir da teoria dos campos de Pierre Bourdieu, o presente artigo tem por objetivo problematizar a internacionalização da educação superior e a circulação internacional das ideias. Para além da apropriação conceitual, ressalta-se o uso prático do aporte para a compreensão do campo da educação superior no Brasil e a interface com o campo acadêmico. Enfatizam-se os limites e as possibilidades de um campo internacional da educação superior.