bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Heart Failure among Diabetic Patients with Ischemic Heart Disease: A Cohort Study
Authors: Abdissa Senbeta Guteta , Deressa Wakgari , Shah Amit 
Published: August 2019

Abstract
Background

In population studies of heart failure (HF), diabetes was shown to be an independent risk factor but the evidence regarding Diabetes Mellitus (DM) having incremental effect in incidence of HF in patients with ischemic heart disease (IHD) is scarce. Our study aimed to assess the incidence of HF in diabetic IHD patients compared to non-diabetic IHD patients.

Methods

A retrospective cohort study was conducted among 306 patients with IHD followed-up at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia. The IHD patients who did not have HF at baseline were followed for 24 months beginning from November 30, 2015. We assessed the incidence of HF in patients with diabetic IHD versus the non-diabetic IHD. Cox proportional hazards models were used to assess the association between diabetic IHD and HF after controlling for important covariates.

Results

Mean age was 56.8 years and male patients accounted for 69%. Prevalence of DM was 31.4% (n=96). During the 24 months follow-up period, 196 (64.1%) had incident HF. Predictors of incident HF were female sex [COR 2.2(1.3-3.8), p=0.006], DM [COR 1.8 (1.1-3.0), p = .04], older age [t (304) = 2.5, p = 0.01, two tailed], bigger left atrial size [t (196) = 2.9, p = 0.005, two-tailed], and lower hemoglobin [t (232) = - 2.3, p = 0.02, two-tailed]. On multivariate Cox regression, DM was significantly associated with incident HF [Hazard Ratio = 2.04, 95% CI: 1.32-3.14, p = 0.001]. Furthermore, when the patients were stratified by hypertension (HTN), DM was associated with worse prognosis, the strongest association being in those with co-existing DM and HTN [HR = 2.57,95% CI =1.66-3.98, p<0.0001] followed by the presence of DM without HTN [HR 2.27, 95% CI = 1.38-3.71, p=0.001].

Conclusion

DM is the strongest predictor of incident HF in patients with IHD. It is worse when DM is combined with HTN.
Hyperhomocysteinemia in association with male gender, advanced age, uric acid and metabolic syndrome: A retrospective cross-sectional study
Authors: Chen Po-Ju , Lu Yueh-Chien , Wang Pei-Ming , Loke Song-Seng 
Published: August 2019

Abstract
Background
Elevated homocysteine level has been proposed as a risk factor for cardiovascular disease. The aim of this study is to evaluate the connection between hyperhomocysteinemia with other factors for early detection of possible cardiovascular disease.
Methods
The data in this retrospectively designed cross-sectional study was retrieved from the health examination database in a medical center located in southern Taiwan in 2016. The correlation of hyperhomocysteinemia with sex, age, body mass index, waist circumference, lipid profile, blood pressure, uric acid, high sensitivity C-reactive protein and lipoprotein were investigated. Both simple and multiple stepwise logistic regression models were used for the assessment of their connection.
Results
A total of 878 subjects with mean age of 55.4 ± 10.8 years were included in the current study and 73 (9.1%) participants had elevated homocysteine levels. Simple logistic regression analysis showed elevated Hcy was significantly associated with sex (OR 0.11, 95% CI 0.04-0.31, P < 0.001), age (OR 1.03, 95% CI 1.00-1.05, P < 0.035), waist circumference (OR 1.04, 95% CI 1.02-1.06, P = 0.001), HDL-C (OR 0.97, CI 0.95-0.99, P = 0.011), triglyceride (OR 1.00, CI 1.00-1.01, P = 0.002), SBP (OR 1.02, CI 1.01-1.03, P = 0.004), DBP (OR 1.04, CI 1.02-1.06, P = 0.001), sugar level (OR 1.01, CI 1.00-1.02, P = 0.021), uric acid (OR 1.39, CI 1.20-1.60, P < 0.001) and the presence of metabolic syndrome (OR 1.81, CI 1.12-2.93, P = 0.016). Multiple stepwise logistic regression analysis was applied and the result showed that male gender (OR 0.15, 95% CI 0.05-0.43, P < 0.001), advanced age (OR 1.03, 95% CI 1.00-1.05, P < 0.036), triglycerides (OR 1.002, 95% CI 1.001-1.004, P = 0.022), systolic blood pressure (OR 1.02, 95% CI 1.00-1.03, P = 0.023) and uric acid (OR 1.26, 95% CI 1.07-1.47, P = 0.005) were significantly associated with the elevation of plasma homocysteine.
Conclusions
Several factors are associated with hyperhomocysteinemia in asymptomatic subjects including sex, age, uric acid and metabolic syndrome components. Among these factors, male, advanced age, systolic blood pressure, plasma level of triglyceride and uric acid were independently associated with hyperhomocysteinemia.
Wistar and Sprague-Dawlay rats demonstrate distinct features of metabolic profile after acute myocardial infarction
Authors: Zheng Yue , Zhang Qiang , Xu Wenxuan , Dong Zhihuan , Huang Lei , Zhang Lei , Li Tong 
Published: August 2019

Abstract
Background: Wistar and Sprague-Dawley (SD) Outbred Rat can be considered the standard rodents for acute myocardial infarction (AMI). However, a direct comparison between Wistar and SD Rat as models of AMI has not been adequately evaluated so far.
Methods: MI was constructed and cardiac functions were measured to show the success of model construction. The metabolites among Wistar, SD rats and patients with AMI were screened, respectively, and further three groups and subgroups metabolic pathway analysis was applied through MetaboAnalyst 4.0.
Results: The animal MI model was constructed successfully. All the QC samples we inserted qualified, which allowed us to confirm that the analytical results were valid. After screening by three methods, there are 42 significant plasma metabolites determined in our study, which consist of 19, 18 and 23 metabolites in Wistar, SD rats and human with AMI, respectively. Therefore, to discuss the similarity of Wistar and SD rats to human, SD rats and human had two similar screened metabolic pathways, whereas Wistars rats and human had three screened metabolic pathways. Through subgroup analysis, Glycerophospholipid metabolism was only one which possessed metabolic pathway difference and did not affected by age and time, whereas Sphingolipid metabolism increased only in AMI when compared to SHAM group.
Conclusions: Sphingolipid metabolism in SD rats is not suggested to be substitute for human metabolic research and the effect of Wistar rats on metabonomic is better than that of SD rats because their metabolic pathways are relatively closer to human’s real world.
Early postnatal care utilization among mothers gave birth in the last six weeks in remote district of Ethiopia: a cross-sectional study
Authors: Ayana Zewde , Wirtu Deselegn , Etana Belachew , Beakuma Tariku Tesfaye 
Published: August 2019

Abstract
Background

majority of neonate and maternal death is occurring in the first week of delivery. Therefore, utilization of postnatal care within the first week of delivery is essential to increase the survival of both a mother and newborn. Therefore, this study was aimed to assess the use of postnatal care in the first week of delivery and factors associated among women who gave birth in the last six weeks.

Method

A community-based cross-sectional study was conducted in the Dano District, one of the remotest districts in the Oromia Region of Ethiopia. A total of 274 women who gave birth during the last six weeks and selected using random sampling method were included in the study. Multivariate logistic regression was used to identify factors associated with the utilization of postnatal care within the first week of delivery. Finding with a p-value less than 0.05 is considered a statistically significant association.

Result

early postnatal care utilization is found to be (within the first week of delivery) was 23.7 percent. Mother given appointment after delivery [AOR=4.84, 95% CI= (1.46, 16.1)], have used postnatal care previous [AOR= 7.4, 95% CI= (2.9, 18.5)] and aware of postnatal care within first week of delivery [AOR=4.27, 95% CI= (1.46, 12.49)] were more likely to use the postnatal care within first week. The qualitative finding indicated traditional beliefs during postpartum also found to affect the use of postnatal care.

Conclusion

The utilization of postnatal care within first week of delivery in was low in the district. Therefore, creating awareness on the benefits of early postnatal care, and designing of strategies to decrease the effect of traditional belief on postnatal care recommended to improve the coverage.
DNA extraction from resin producing Boswellia tree
Authors: Khan Abdul Latif , Khan Adil , Asaf Sajjad , Al-Harrasi Ahmed , Al-Rawahi Ahmed 
Published: August 2019

Abstract
The wild nature of plant and the presence of the secondary compounds e.g., Resin and phenolic compound make DNA extraction problematic. Some of them will co-precipitate with DNA during extraction and inhibit further enzymatic modification of the DNA. Furthermore large amounts of complex polysaccharides also make extraction of usable DNA impossible. Previously reported protocols yielded highly viscous and slimy DNA preparations that were not amenable to further analysis. We tried many commonly used protocols but were unable to isolate high quality DNA from the gum containing plant Bosweliia sacra. We did extensive optimization of the Cetyl Trimethyl Ammonium Bromide \(CTAB) protocol established by Doyle in 1987 to extract DNA which is feasible for PCR amplification. In this study, we have specifically tested the previously developed CTAB based protocols developed by I Haque adapted for Commiphora wightii and Bipin Deochand Lade protocol developed for Passiflora foetida. Both are developed for plants, which contain high amount of secondary metabolites, polysaccharides and phenolic compounds. Furthermore, we investigate the possibility to extract DNA from resin producing plants which is feasible for downstream application. To our knowledge, this is the first optimized protocol which a rapid and less laborious method for the extraction of DNA from Boswellia species \(Boswellia sacra and Boswellia elongata found in Oman and Yemen respectively) which are resin \(Luban) producing plant. The isolated DNA by the currently optimized protocol were suitable for polymerase chain reaction \(PCR) mediated amplification for applications genetic diversity and DNA barcoding.
Quantifying membrane protein oligomerization using two-dimensional fluorescence intensity fluctuation spectrometry
Authors: Stoneman Michael R. , Biener Gabriel , Ward Richard J. , Pediani John D. , Badu Dammar , Eis Annie , Popa Ionel , Milligan Graeme , Raicu Valerică 
Published: August 2019

Abstract
Current methods for determining membrane protein association in cells are either very time consuming, require complicated procedures, or lack the sensitivity needed to assess the effect of concentration or ligand binding on the observed oligomerization. To overcome these limitations, we provide a detailed protocol for quantifying the relative abundance and stability of oligomers of differing sizes using two-dimensional fluorescence intensity fluctuation (2D-FIF) spectrometry. The approach can be implemented using a standard laser scanning fluorescence microscope along with custom written software for image analysis. This method may be applied to evaluate the extent of oligomerization as a function of receptor concentration and is particularly suited to assess the effects of agonists and antagonists on the oligomeric size of membrane receptors of interest.
HetEnc: A Deep Learning Predictive Model for Multi-type Biological Dataset
Authors: Wu Leihong , Liu Xiangwen , Xu Joshua 
Published: August 2019

Abstract
Background: Researchers today are generating unprecedented amounts of biological data. One trend in current biological research is integrated analysis with multi-platform data. Effective integration of multi-platform data into the solution of a single or multi-task classification problem; however, is critical and challenging. In this study, we proposed HetEnc, a novel deep learning-based approach, for information domain separation.

Results: HetEnc includes both an unsupervised feature representation module and a supervised neural network module to handle multi-platform gene expression datasets. It first constructs three different encoding networks to represent the original gene expression data using high-level abstracted features. A six-layer fully-connected feed-forward neural network is then trained using these abstracted features for each targeted endpoint. We applied HetEnc to the SEQC neuroblastoma dataset to demonstrate that it outperforms other machine learning approaches. Although we used multi-platform data in feature abstraction and model training, HetEnc does not need multi-platform data for prediction, enabling a broader application of the trained model by reducing the cost of gene expression profiling for new samples to a single platform. Thus, HetEnc provides a new solution to integrated gene expression analysis, accelerating modern biological research.
Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis
Authors: Weise Hannes , Naros Andreas , Weise Christina , Reinert Siegmar , Hoefert Sebastian 
Published: August 2019

Abstract
ABSTRACT
Background
More than 90% of all infections in the head and neck region can be traced back to an odontogenic origin. In rare cases they can lead to sepsis, which may pose a vital threat to the patient. The purpose of this study was to analyse characteristics concerning etiology and progress of severe odontogenic infections with a fulminant development.
Methods
All patients with odontogenic infections requiring hospital admission were included in a retrospective analysis conducted from 02/2012 to 09/2017. Of 483 patients 16 patients (13 male, 3 female) showed severe exacerbation with septic progress. The average age was 52.8 years. All patients underwent at least one surgical procedure that involved an extraoral incision and drainage as well as high volume irrigation intraoperatively. At least one revision was required for four of the patients. Three patients showed an exceedingly severe disease progression with multiorgan dysfunction syndrome (MODS) and circulatory arrest. Antibiotic treatment was adjusted according to the results of an antibiogram and resistogram. Irrigation with saline was done several times a day.
Results
Sixteen patients showed odontogenic infections that spread over multiple maxillo-facial and cervical regions accompanied by septic laboratory signs. All these patients needed intensive care and a tracheostomy. The hospitalization period was 27.8 days on average. In 16 cases risk factors for the development of odontogenic abscesses like diabetes mellitus, obesity, chronic alcohol and nicotine abuse, rheumatism and poor oral hygiene were present. Intraoperative swabs showed a typical polymicrobial aerobic and anaerobic spectrum of oral bacteria, especially anaerobes and streptococci, mainly Streptocococcus viridans.
Conclusion
Odontogenic infections with fulminant progression should be treated based on clinical and imaging data with immediate surgical incision and drainage including elimination of odontogenic foci as well as intensified intra- and postoperative irrigation. If needed, repeat imaging followed by further incisions should be performed. Immediate antibiotic treatment adapted to the antibiogram is of utmost importance. A combination of tazobactam and piperacillin has proven to be a good first choice and can be recommended for abscesses that spread over multiple levels with initial signs of severe infections.
Transverse Versus Longitudinal Uterine Incision in Abdominal Myomectomy: A Randomized Controlled Trial
Authors: Elguindy Alaa , Hemeda Hosam , Shawky Mohamed Esmat , Nawara Maii , Elsenity Mohamed , Elsayed Medhat Adel , Fahim Ahmed , Afifi Khaled 
Published: August 2019

Abstract
Background: It is unclear whether transverse uterine incision is non-inferior to longitudinal incision during myomectomy with regard to bleeding. Our aim was to compare between transverse and longitudinal uterine incisions in myomectomy.
Methods: A parallel randomized controlled single-blinded study in a university affiliated hospital, in the period between January 2017 and April 2018, in which 52 women candidates for abdominal myomectomy were randomized into transverse uterine incision or longitudinal uterine incision groups (26 in each group). Intraoperative blood loss (estimated directly by blood volume in suction bottle and linen towels and indirectly by difference between preoperative and postoperative hematocrit), operative time and postoperative fever were analyzed.

Results: No statistically significant difference was found between transverse and longitudinal incisions regarding intraoperative blood loss (389.7 ± 98.56 ml vs 485.04 ± 230.6 ml respectively, p value=0.07), operative time (59.96 ± 16.78 min vs 66.58 ± 17.33 min respectively, p value=0.18), and postoperative fever (4% vs 8.33%, p value=0.6).
Conclusion: Transverse uterine incision does not cause more blood loss than longitudinal incision and is a reasonable option during abdominal myomectomy.
Trial registration: NCT03009812 at clinicaltrials.gov, registered January 2017
Health systems readiness to provide geriatric friendly care services in Uganda: a cross-sectional study
Authors: Ssensamba Jude Thaddeus , Mukuru Moses , Nakafeero Mary , Ssenyonga Ronald , Kiwanuka Suzanne N 
Published: August 2019

Abstract
Background

As ageing emerges as the next public health threat in Africa, there is a paucity of information on how prepared its health systems are to provide geriatric friendly care services. In this study, we explored the readiness of Uganda’s public health system to provide geriatric friendly care services in Southern Central Uganda.

Methods

Four districts with the highest proportion of old persons in Southern Central Uganda were purposively selected, and a cross section of 18 randomly selected health facilities (HFs) were visited and assessed for availability of key items deemed important for provision of geriatric friendly services; as derived from World Health Organization’s Age-friendly primary health care centres toolkit. Data was collected using an adapted health facility geriatric assessment tool, entered into Epi-data software and analysed using STATA version 14. Kruskal-Wallis and Dunn’s post hoc tests were conducted to determine any associations between readiness, health facility level and district.

Results

The overall readiness index was 16.92 (SD ±4.19) (range 10.8 - 26.6). This differed across districts; Lwengo 17.91 (SD ±3.15), Rakai 17.63 (SD ±4.55), Bukomansimbi 16.51 (SD ±7.18), Kalungu 13.74 (SD ±2.56) and facility levels; Hospitals 26.62, Health centers four (HCIV) 20.05 and Health centers three (HCIII) 14.80. Low readiness was due to poor scores with regard to; leadership (0%), financing (0%), human resources (1.7%) and health management information systems (HMIS) (11.8%) WHO building blocks. Higher level HFs were statistically significantly friendlier than lower level HFs (p= 0.015). The difference in readiness between HCIIIs and HCIVs was 2.39 (p=0.025).

Conclusion

There is low readiness of public health facilities to provide geriatric friendly care services in Uganda. This is due to gaps in all of the health system building blocks. There is a need for health system reforms in Uganda to adequately cater for service provision for old people if the 2020 global healthy ageing goal is to be met.
Emoticons e Letramento Visual: Pedagogia da Imagem
Authors: Costa Ana Valéria De Figueiredo da , Carneiro Isabel Almeida 
Published: August 2019

Você está em silêncio e, de repente, seu telefone celular emite um som avisando que chegou mensagem pelo aplicativo whatsapp, popularmente conhecido com zap. Por um momento, a atividade que se realiza é interrompida. Não se lê nenhuma palavra escrita; aparece apenas figurinha (conhecida como emoji, emoticon ou smile) avisando que a resposta que se esperava é positiva. Sem nenhuma palavra escrita ou gravada, você - e eu também – entendemos que tudo está bem resolvido. A partir dessa contextualização, tomando por base a força da imagem como comunicação e, ainda, a facilidade de acesso às novas Tecnologias Digitais de Informação e Comunicação (TDIC) nos dispositivos móveis, o presente artigo tem como objetivo propor reflexões sobre a utilização de imagens para a comunicação sem palavras, porém repleta de significados partilhados.
Estimation of the COVIMEP Variation in a HCCI Engine
Authors: POLAT Seyfi , SOLMAZ Hamit , CALAM Alper , YILMAZ Emre 
Published: August 2019

In this study, variation of the COVIMEP was tried to be predicted by using the artificial neural network method for 4-stroke, 4-cylinder, direct injection and supercharged HCCI engine experimental data obtained by using n-heptane fuel at 60 oC intake air temperature, 1000 rpm engine speed at different inlet air intake pressure. Intake air inlet pressure and lambda were used as input data in artificial neural network model. The COVIMEP value was used as the target. Three layers and five neurons were used to construct the network using the Levenberg-Marquardt algorithm. Correlation between targets and outputs for teaching, accuracy and testing were obtained as 0.97989, 0.9504 and 0.91644, respectively. Total correlation factor was found as 0.96983. As a result of the study, it was seen that the stored data and the estimated COVIMEP data were compatible.
An Analysis of Grammatical Errors Committed by the Tenth Grade Students of SMA Negeri 1 Baturiti in Writing Recount Text in Academic Year 2014/2015
Authors: Purnayatri L A , Seken I Ketut , Adnyani L D.S. 
Published: August 2019

The present study aimed at 1) finding the types of grammatical errors committed by the tenth grade students of SMA Negeri 1 Baturiti in writing recount text in academic year 2014/2015; and 2) finding the sources of the errors committed by the tenth grade
students of SMA Negeri 1 Baturiti in writing recount text in academic year 2014/2015. This study was designed as descriptive-qualitative study. The methods used to collectdata were document analysis and interview. The instruments used were project and interview guide. The data in this study were analyzed by using data analysis theory
proposed by Miles and Hubarman. The types of grammatical errors used in this study were based on the surface strategy taxonomy proposed by Dulayat alwhile the sources of the errors were based on the combination of theories proposed by Richards and Brown.
Model of error analysis used in this study was the one proposed by Gass and Selinker. The result of the study showed that the subject committed 167 errors in their writing, namely misformation (29.94%), addition (27.54%), omission (24.55%), and misordering (17.96%).
PEMAHAMAN GURU KELAS AWAL SEKOLAH DASAR TERHADAP MODEL PEMBELAJARAN TERPADU BERBASIS BUDAYA
Authors: Fatmawati Nia , Kisno Kisno 
Published: August 2019

Penelitian ini bertujuan untuk memberikan gambaran pemahaman guru kelas awal sekolah dasar tentang implementasi model pembelajaran terpadu berbasis budaya. Metode penelitian menggunakan pendekatan kuantitatif. Sampel penelitian terdiri dari 27 lembaga sekolah dasar dengan jumlah 46 orang guru kelas awal. Lokasi penelitian dilakukan pada beberapa lembaga sekolah dasar di kota Metro. Pengambilan sampel dilakukan melalui teknik cluster random sampling. Teknik dan pengumpulan data menggunakan angket dan dokumen berupa rencana pelaksanaan pembelajaran terpadu. Data dianalisis secara kuantitatif. Hasil penelitian menunjukkan bahwa pemahaman guru tentang pembelajaran terpadu berbasis budaya mencapai 61,15%.