bluuebunny/crossref_metadata_2025_split huggingface dataset:
Esthetic Rehabilitation of Coronal Fractures of Maxillary Anterior Teeth after Pulpotomy: Report of Cases.
Authors: Gupta Alpa , Saini Hans , Duhan Jigyasa , Bala Shashi 
Published: October 2018

AbstractThe present case report describes management of two cases with complicated coronal fracture where fractured fragments were reattached, before reattachment of fractured fragments pulpotomy was performed in both cases using different pulpotomy agents, calcium hydroxide in patient with immature apex and mineral trioxide aggregate (MTA) in patient where root development was complete. Both the patients were evaluated for sign and symptoms for a period of 18 months with successful outcome.
Case Series of Intracanal Rehabilitation with Light Transmitting Posts
Authors: Vats Anjali , Vats Ankur , Kothari Paras 
Published: October 2018

AbstractIntra-radicular rehabilitation is a procedure in which the root canals with very little remaining dentin thickness are strengthened by the use of such material that bonds and reinforces the root structure. In this case report, intra radicular rehabilitation with the use of seventh generation bonding agent and flowable composite is described and discussed as a treatment approach for the restoration of a thin fragile root. The procedure provides for an extended clinical application of the all-in-one bonding agent resulting in conservative, reliable treatment approach for the treatment of compromised root canals due to variety of reasons
Alloderm for Root Coverage: A Case Report
Authors: Goyal Sachin , Gupta Garima , Nayyar Nandini , Garg Avnika 
Published: October 2018

AbstractThe main indication for root coverage procedures is esthetic or cosmetic demand by the patient. Root coverage procedures mainly include use of pedicle soft tissue grafts or free autogenous grafts. Recently acellular dermal matrix allograft has been introduced as a substitute for donor tissue in gingival augmentation procedures.
Nonsyndromic Oligodontia: A Rare Case Report with Review of Literature
Authors: Bajaj Puneet , Sabharwal Robin , Joshi Sonia 
Published: October 2018

AbstractDental agenesis is the most common developmental anomaly in humans and is frequently associated with several other oral abnormalities. In the literature, some terms are used to describe missing teeth like Oligodontia, Anodontia and Hypodontia. Oligodontia is defined as the developmental absence of six teeth or more, excluding third molars. It can be isolated or as a part of a syndrome such as in ectodermal dysplasia. The present case describes agenesis of permanent teeth which are non-familial and with no apparent systemic abnormalities
Oral Health Related Quality Of Life: Perspectives
Authors: Sood Poonam , Ahuja Gourav , Makkar Diljot , Gaba Rohini , Sidana Jasmohan 
Published: October 2018

AbstractGood oral health is essential for the overall wellbeing of an individual. Oral diseases like dental caries, periodontal diseases and oral cancer are highly prevalent and can lead to pain, discomfort, anxiety, poor facial appearance, low self esteem and impaired function. With patient centric measures gaining importance, it is essential to incorporate patient centric measures while restoring the oral health. OHRQoL aims to add this wider view to the clinical assessment of an individual's oral health. It challenges biomedical model of health and provides complete view of the health and disease status of an individual. It is an individual's assessment of how functional, psychological, social and other factors affect personal wellbeing. Various generic and oral health specific quality of life instruments have been developed to assess oral health related quality of life. It has implications in routine clinical practice, research, patient education, surveys and policy formulations. The overall result is a satisfied individual, clinician, researcher and community.
Sealing Ability of Novel Hydrophilic Single-Cone Obturation Systems in an Oval Canal: an In-Vitro Glucose Leakage Study
Authors: Hegde Vibha , Arora Shashank 
Published: October 2018

Abstract
Objective: To compare the sealing ability of three single-cone obturation systems using a glucose leakage model. Materials and Methods: A total of 90 freshly extracted human mandibular incisors with oval canals were selected and their crowns were cut. The root canal of each sample was instrumented using a rotary crown down technique and then divided into four experimental (n = 20 each) and two control groups (n = 5 each). Samples in the experimental groups were filled as follows: Group 1, cold lateral condensation using Gutta-percha/AH Plus; Group 2, single-cone C-Points/Smart-Paste Bio Sealer; Group 3, single cone Bio-Ceramic Impregnated Gutta-Percha/Endo-Sequence Bio-Ceramic Sealer; Group 4, single-cone Resilon/RealSeal SE. After 7 days, the sealing ability of root canal fillings was tested at different time intervals using glucose leakage model. Glucose leakage values were measured using a spectrophotometer and statistically analyzed. Results: The four experimental groups presented significantly different glucose leakage values at all test periods (P < 0.05). At the end of the observation period, the cumulative glucose leakage values of Groups 2 and 3 were significantly lower than those of Groups 1 and 4 (P < 0.05). Conclusion: C-Points/Smart-Paste Bio and Bio-Ceramic Impregnated Gutta-Percha/Endo-Sequence Bio-Ceramic Sealer combinations provided the superior sealing ability over the lateral condensation technique.
Comparison of Anti-Bacterial and Anti-Inflammatory Properties of Neem, Curcumin and Aloe Vera in Conjunction with Chlorhexidine as an Intracanal Medicament – an In-Vivo Study.
Authors: Khetarpal Samta , Bansal Abhishek , Kukreja Navneet 
Published: October 2018

Abstract
Aim & Objective: The main aim of this study was to evaluate the potential of Neem, Curcumin and Aloe vera as an effective intracanal medicament in root canal therapy of infected teeth and to determine the antimicrobial and anti-inflammatory properties of these three herbal substances used in the study. Material and Method: In this study, thirty three patients(33) within the age group of 25-40 years with two single rooted anterior teeth, presenting with periapical radiolucency requiring endodontic therapy were selected. These 33 patients were divided into two groups, in which one was the test and another was control in one single patient. The control samples were taken from all the 33 patients i.e (33 samples) in which chlorhexidine is used as intracanal medicament, whereas the test groups were divided into another three respective groups with 11 samples in each group on the basis of three herbal intracanal medicaments used in this study. The antimicrobial and anti-inflammatory property was assessed in our study using the microbial colony count method and the Visual analogue pain scale method respectively. Results: Test Group A(Neem) showed the highest antibacterial activity with maximum reduction in microbial colony count scores. and the test Group B(Curcumin) showed the highest anti-inflammatory activity with maximum reduction in the VAS pain score. On comparing test groups with control group and antimicrobial property was analyzed. The results were statistically non-significant when Group A(Neem) was compared with Control group(Chlorhexidine) and statistically significant when Group B(Curcumin) and Group C(Aloe vera) was compared with Chlorhexidine.
Comparative Evaluation of Salivary Interleukin-8 Levels in Diabetics, Hypertensives and Smokers with Chronic Periodontitis
Authors: Jain Sanjeev , Kaur Harjit , Aggarwal Nisha , Gupta Milli , Saxena Divya , Pandav Gaurav 
Published: October 2018

Abstract
Background: Cytokines are pivotal to the pathogenesis of periodontal disease and may be used as markers in diagnosis. Systemic diseases and smoking are considered risk factors that have been associated with periodontal disease progression. Cytokine production may also be influenced by smoking and systemic diseases leading to an imbalance that disturbs the host–parasite relationship. Aim: The aim of the present study was to determine and compare the levels of salivary IL-8 in diabetics, smokers and hypertensive patients with chronic periodontitis. Materials and method: A total of 80 patients with chronic periodontitis were included in the study. They were divided into four groups: 20 controls, 20 diabetics, 20 hypertensives and 20 smokers. Unstimulated saliva samples were collected at first visit and IL-8 levels were measured by enzyme linked immunosorbent assay (ELISA). Results: It was found that as compared to control group, diabetic group presented with higher levels of IL-8 whereas hypertensive and smoker groups presented with lower levels of IL-8. After statistical analysis it was found that this alteration was significant in smokers group only. Conclusion It can be concluded from the study that the levels of inflammatory biomarkers in chronic periodontitis patients are altered with systemic factors.
Overdenture Utilizing Access Post System - A Case Report
Authors: Aggarwal Sumit , Jain Shalu , Raghav Pradeep 
Published: October 2018

AbstractOverdenture treatment precludes the inevitability of “floating plastic” in edentulous mouths. It is an effective and versatile way of restoring teeth and improving facial contours. This case report presents an insight on utilizing a new innovative ‘Access post overdenture’ system which provides more advantages than any other passive overdenture post. It’s patented thick walled hollow tube design, stabilizing flange and undercuts of the shank offer strength, retention and stability with the added insurance policy of retreatability. The access post overdenture fabricated was well retentive and esthetic serving as a conservative approach to root preservation.
Erythema Multiforme- Case Report with Review
Authors: Gupta Neha , Bansal Amol , Bansal Aarti 
Published: October 2018

AbstractErythema Multiforme is a rare, acute, inflammatory mucocutaneous condition caused by a hypersensitivity reaction with the appearance of cytotoxic T lymphocytes in the epithelium that induce apoptosis in keratinocytes, which leads to satellite cell necrosis. Reactions to drugs are quite common and are generally mild, hence not reported. However, occasionally life threatening reactions including Erythema multiforme major (Steven Johnson’s syndrome) and Toxic Epidermal Necrolysis may occur. A wide spectrum of drugs can sometimes give rise to Erythema Multiforme. We report a case of Erythema Multiforme following administration of Non Steroidal Anti-Inflammatory Drugs.
Leiomiosarcoma intratesticular primario diagnosticado por biopsia hepática percutánea ecodirigida
Authors: Castellanos González M. , Delgado Martínez C. , Gómez Rubio M. , Butrón Vila M. , Arance Gil J. , Cuenca Morón B. 
Published: October 2018

ResumenSe presenta el caso clínico de un varón de 80 años diagnosticado de leiomiosarcoma testicular primario, a raíz de alteraciones del perfil hepático en analítica sanguínea y lesiones ocupantes de espacio (LOE) hepatoesplénicas en ecografía abdominal. En primer lugar, se realizó punción de lesión hepática y posteriormente orquiectomía radical, revelando concordancia histológica, compatible con leiomiosarcoma intratesticular. Presentamos el caso clínico debido a la rareza de ese tipo de tumores, sobre todo en estadio III, y su peculiar diagnóstico, tras la detección de alteración hepática tanto analítica como ecográfica.
HSP90 is a chaperone for DLK and is required for axon injury signaling
Authors: Karney-Grobe Scott , Russo Alexandra , Frey Erin , Milbrandt Jeffrey , DiAntonio Aaron 
Published: October 2018

Significance
Defining mechanisms of axon injury signaling is critical to understand axon regeneration. This knowledge can be used to develop strategies of axonal repair. Identification of such injury signals has been limited by traditional in vivo assays of proregenerative injury signaling. Here, we describe an in vitro screening platform that specifically identifies proregenerative axon injury signals in mouse neurons. We show that HSP90 is required for injury signaling and detail a mechanism by which HSP90 chaperones the essential proregenerative kinase, dual leucine zipper kinase (DLK). Thus, this work also describes HSP90 as a previously unidentified regulator of DLK, a critical neuronal stress sensor that drives axon regeneration, degeneration, and neurological disease.
Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts
Authors: Wu Kai , Oberstein Adam , Wang Wei , Shenk Thomas 
Published: October 2018

Significance
Human CMV (HCMV) is a major cause of birth defects, an opportunistic infection in untreated HIV/AIDS, and a life-threatening complication in immunosuppressed transplant patients. HCMV infects multiple different cell types, so understanding mechanisms supporting the entry of the virus into different cells is crucial to deciphering its pathogenesis. Two viral glycoprotein complexes (trimeric and pentameric complexes) are known to control HCMV tropism in different cell types. Here we have refined our understanding of the mechanism by which the cell-surface receptor tyrosine kinase, PDGF receptor-α, supports the entry of HCMV into fibroblasts.
Bayesian approach to SETI
Authors: Grimaldi Claudio , Marcy Geoffrey W. 
Published: October 2018

SignificanceOngoing and future initiatives in the search for extraterrestrial intelligence (SETI) will explore the Galaxy on an unprecedented scale to find evidence of communicating civilizations beyond Earth. Here, we construct a Bayesian formulation of SETI to infer the posterior probability of the mean number of radio signals crossing Earth, given a positive or a null outcome of all-sky searches for nonnatural radio emissions. We show that not detecting signals within∼40kly from Earth is compatible with the absence in the entire Galaxy of detectable emitters of a wide range of radiated power. The discovery of even a single emission within∼1kly implies instead that over 100 signals typically cross our planet from the Milky Way.
Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
Authors: Heusser Stephanie A. , Lycksell Marie , Wang Xueqing , McComas Sarah E. , Howard Rebecca J. , Lindahl Erik 
Published: October 2018

SignificanceMolecular mechanisms of general anesthetic modulation in pentameric ligand-gated ion channels remain controversial. Here we present molecular simulations and functional data that reveal correlations between dynamic differences in a membrane-accessible cavity and dramatic anesthetic effects, separate inhibitory and potentiating effects within the same electrophysiology recordings, and support a model for communication between the lipid bilayer and ion channel pore. In particular, enhanced electrostatic interactions in the membrane-accessible site were associated with a unique mode of anesthetic potentiation, persisting tens of minutes after washout. These results offer a bridge between lipid- and receptor-based theories of anesthesia, with the potential to inform both mechanistic understanding and drug development.
Active apolar doping determines routes to colloidal clusters and gels
Authors: Massana-Cid Helena , Codina Joan , Pagonabarraga Ignacio , Tierno Pietro 
Published: October 2018

Significance
Collections of polar active particles have been unable to form stable and long-living structures due to the presence of self-propulsion. We solve this timely issue by introducing the concept of “active doping” and show that a few light-activated apolar, i.e., non–self-propelling, units can be used to rapidly trigger the formation of solid clusters and gels composed of passive colloidal particles. Our active doping can be used to assemble disparate microscopic objects, including synthetic or biological ones, paving the way toward the extension of fundamental concepts of gel and glass formation to active out-of-equilibrium systems.
Beyond Verismo: Massenet's La Navarraise and ‘Realism’ in Fin-de-siècle Paris
Authors: Bentley Charlotte 
Published: October 2018

AbstractThe ‘réalisme’ of Massenet's La Navarraise divided critics at its belated Parisian première on 3 October 1895. While the opera has typically been read as a straightforward attempt at French verismo, this article suggests a more complex set of ways in which modernity and the modern world shaped critical perceptions of and responses to realism. Placing La Navarraise within its wider cultural and technological contexts, I argue that the critics’ ambivalence to its realism provides insight into the changing and contested nature of critical perception and subjectivity in Paris in the final years of the nineteenth century.
Single-nucleotide variants in human RNA: RNA editing and beyond
Authors: Guo Yan , Yu Hui , Samuels David C , Yue Wei , Ness Scott , Zhao Ying-yong 
Published: October 2018

AbstractThrough analysis of paired high-throughput DNA-Seq and RNA-Seq data, researchers quickly recognized that RNA-Seq can be used for more than just gene expression quantification. The alternative applications of RNA-Seq data are abundant, and we are particularly interested in its usefulness for detecting single-nucleotide variants, which arise from RNA editing, genomic variants and other RNA modifications. A stunning discovery made from RNA-Seq analyses is the unexpectedly high prevalence of RNA-editing events, many of which cannot be explained by known RNA-editing mechanisms. Over the past 6–7 years, substantial efforts have been made to maximize the potential of RNA-Seq data. In this review we describe the controversial history of mining RNA-editing events from RNA-Seq data and the corresponding development of methodologies to identify, predict, assess the quality of and catalog RNA-editing events as well as genomic variants.
Opening the Black Box of Citations: A Qualitative Analysis on the Basis of the Taxonomy of Erikson and Erlandson
Authors: Marí-Sáez Víctor-M , Ceballos-Castro Gonzalo 
Published: October 2018

AbstractOver recent years, citation practice has become progressively more pertinent to academic production, a relevance that poses the challenge of addressing this object of study not only from a quantitative perspective, but also using qualitative approaches. On the basis of these premises, the aim of this article is to analyze, from a qualitative perspective, the literature on communication for development and social change (CDSC) published in the top 10 communication journals in Spain. To this end, a qualitative analysis of the most frequently cited papers on this topic was performed on the basis of the citation categories suggested by M. G. Erikson and P. A. Erlandson (2014), as well as the implications and consequences of their widespread use. The conclusions of this article point to the predominance of citations that, in many cases, reveal a disturbing disregard for the cited works and a general lack of scholarly debate between authors and conflicting paradigms.
Explaining farm structural change in the European agriculture: a novel analytical framework
Authors: Neuenfeldt Sebastian , Gocht Alexander , Heckelei Thomas , Ciaian Pavel 
Published: October 2018

Abstract
In this paper, we analyse the drivers of farm structural change in the EU-27, applying a novel analytical framework in the field of agricultural economics known as the multiplicative competitive interaction (MCI) model. MCI offers a more parsimonious specification for estimating models of regional farm group shares compared to the often-applied Markov approach. The MCI framework enables farm group-specific equations, which are used to account for drivers specific to certain farm groups. The MCI framework explains farm group shares at the regional level taken from the Farm Structure Survey (FSS) using socio-economic variables from the Farm Accountancy Data Network (FADN) and other databases for the period 1989–2013. We consider eight production specialisations and two size classes at the NUTS 2 regional level. The results indicate that the past farm structure explains approximately 36 per cent of the EU farm structure variation across regions and time, followed by natural conditions (16 per cent), agricultural prices (14 per cent), macroeconomic variables (9 per cent), subsidies (7 per cent), population (6 per cent) and agricultural income (6 per cent). Further, we have run a simulation experiment where we derived elasticities of structural change with respect to time-varying variables. The structural change appears to be the most elastic with respect to income and macroeconomic variables.
Structured illumination approaches for super-resolution in plant cells
Authors: Shaw Sidney L , Thoms David , Powers James 
Published: October 2018

Abstract
The advent of super-resolution techniques in biological microscopy has opened new frontiers for exploring the molecular distribution of proteins and small molecules in cells. Improvements in optical design and innovations in the approaches for the collection of fluorescence emission have produced substantial gains in signal from chemical labels and fluorescent proteins. Structuring the illumination to elicit fluorescence from specific or even random patterns allows the extraction of higher order spatial frequencies from specimens labeled with conventional probes. Application of this approach to plant systems for super-resolution imaging has been relatively slow owing in large part to aberrations incurred when imaging through the plant cell wall. In this brief review, we address the use of two prominent methods for generating super-resolution images in living plant specimens and discuss future directions for gaining better access to these techniques.
Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations
Authors: Majumdar Manasi , Sharif Salmaan , Klapsa Dimitra , Wilton Thomas , Alam Muhammad Masroor , Fernandez-Garcia Maria Dolores , Rehman Lubna , Mujtaba Ghulam , McAllister Gina , Harvala Heli , Templeton Kate , Mee Edward T , Asghar Humayun , Ndiaye Kader , Minor Philip D , Martin Javier 
Published: October 2018

Abstract

Background
Enteroviruses are common human pathogens occasionally associated with severe disease, notoriously paralytic poliomyelitis caused by poliovirus. Other enterovirus serotypes such as enterovirus A71 and D68 have been linked to severe neurological syndromes. New enterovirus serotypes continue to emerge, some believed to be derived from nonhuman primates. However, little is known about the circulation patterns of many enterovirus serotypes and, in particular, the detailed enterovirus composition of sewage samples.

Methods
We used a next-generation sequencing approach analyzing reverse transcriptase polymerase chain reaction products synthesized directly from sewage concentrates.

Results
We determined whole-capsid genome sequences of multiple enterovirus strains from all 4 A to D species present in environmental samples from the United Kingdom, Senegal, and Pakistan.

Conclusions
Our results indicate complex enterovirus circulation patterns in human populations with differences in serotype composition between samples and evidence of sustained and widespread circulation of many enterovirus serotypes. Our analyses revealed known and divergent enterovirus strains, some of public health relevance and genetically linked to clinical isolates. Enteroviruses identified in sewage included vaccine-derived poliovirus and enterovirus D-68 stains, new enterovirus A71 and coxsackievirus A16 genogroups indigenous to Pakistan, and many strains from rarely reported serotypes. We show how this approach can be used for the early detection of emerging pathogens and to improve our understanding of enterovirus circulation in humans.