bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Everolimus and Octreotide LAR in Patients with Nonfunctioning Gastrointestinal Neuroendocrine Tumors: The GETNE1003_EVERLAR Study
Authors: Capdevila Jaume , Teulé Alexandre , Barriuso Jorge , Castellano Daniel , Lopez Carlos , Manzano Jose Luis , Alonso Vicente , García-Carbonero Rocío , Dotor Emma , Matos Ignacio , Custodio Ana , Casanovas Oriol , Salazar Ramon ,   on behalf of the EVERLAR study investigators
Published: May 2018

Abstract

Background
Antitumor activity of the combination of somatostatin analogues (SSAs) and the mammalian target of rapamycin (mTOR) inhibitor everolimus in patients with neuroendocrine tumors (NETs) has been reported but not confirmed in prospective trials.

Materials and Methods
This prospective, multicenter, single-arm phase II EVERLAR study evaluated everolimus 10 mg/day and the SSA octreotide 30 mg every 28 days in patients with advanced nonfunctioning well-differentiated gastrointestinal NETs (GI-NETs) that progressed in the last 12 months (ClinicalTrials.gov NCT01567488). Prior treatment with SSAs and any systemic or locoregional therapy was allowed except for mTOR inhibitors. Patients continued treatment until disease progression or unacceptable adverse events (AEs). The primary endpoint was progression-free survival (PFS) at 12 months; secondary endpoints included early biochemical response, objective response rate (ORR) by RECIST v1.0, overall survival (OS), AEs, activation of mTOR pathway (insulin-like growth factor 1 receptor [IGF1R] and phosphoS6 [pS6] expression).

Results
Forty-three patients were included in the intent-to-treat analyses. After 12 months of treatment, 62.3% (95% confidence interval [CI] 48%–77%) of patients had not progressed or died. The 24-month PFS rate was 43.6% (95% CI 29%–58%). The confirmed ORR was 2.3%, and stable disease was 58.1%. Median OS was not reached after 24 months of median follow-up. Dose reductions and temporary interruptions due to AEs were required in 14 (33%) and 33 (77%) patients, respectively. The most frequent AEs were diarrhea, asthenia, mucositis, rash, and hyperglycemia. No correlation was observed between IGFR1 and pS6 expression and PFS/OS.

Conclusion
The everolimus-octreotide combination provided clinically relevant efficacy in nonfunctioning GI-NETs, similar to the results of RADIANT-2 in functioning setting.

Implications for Practice
The EVERLAR study reports prospective data of somatostatin analogue in combination with everolimus in nonfunctioning gastrointestinal neuroendocrine tumors suggesting meaningful activity and favorable toxicity profile that supports drug combination in this setting.
Elaboration of Research on Student Withdrawal from Universities in Russia and the United States
Authors: Gorbunova Elena 
Published: May 2018

Student withdrawal (attrition) is becoming an actual phenomenon due to demographic changes, modernization of the economy and education, especially for universities located in economically depressed areas. The tradition of research on student withdrawal is still being formed in Russia, so it is important to clarify the main terminology used for the analysis of withdrawal, to develop a theoretical framework that takes into account the specifics of Russian universities, and to specify the prospects for the elaboration of research. A review of the terminology used in international studies to study the withdrawal as well as the history of studying this phenomenon in the USA is presented. The basic concepts of withdrawal, developed in sociology, psychology, organization theory and economics, are considered. They indicate the effectiveness of accounting for a wide range of factors of differing natures in the study of withdrawal: the processes of social and academic integration, the psychological characteristics of students, the organizational characteristics of the university and educational programs. When adapting existing models to Russian higher education, it is important to take into account that compulsory withdrawal caused by academic failure of students predominates in Russian universities, while international models were created to describe voluntary withdrawal from higher education institutions. National research which can serve as the basis for the development of a model of student withdrawal from Russian universities is analyzed.
Jogo sobre a segurança alimentar: conscientizando alunos e manipuladores de alimentos
Authors: Cordeiro Fabiana 
Published: May 2018

<p class="Pargrafobsico">Este relato foi resultado de um projeto de extensão realizado no Cefet/RJ (<em>Campus </em>Maria da Graça) com objetivo de sensibilizar estudantes da área técnica da segurança do trabalho e manipuladores de alimentos em relação ao conceito de segurança alimentar. Foi desenvolvido um jogo sobre a legislação de boas práticas de fabricação para serviços de alimentação para torná-la de mais fácil entendimento. Como resultado tanto estudantes quanto manipuladores se tornaram conscientes da importância do tema.</p>
GSM Operatör Markalarının Tüketici Açısından Değerlendirilmesi
Authors: ŞENGÜN Halil İbrahim , MENTEŞ Nurettin 
Published: May 2018

Günümüz Bilgi Çağı’nda
en çok bilgiye sahip olup bunu en etkin kullanabilen insanlar, kurumlar,
ülkeler daha başarılı olmaktadır. Bilgi
sahibi olmanın yanında bu bilgiyi kullanıp paylaşmak da hayati öneme sahiptir. Cep
telefonu bilgiyi anında paylaşma imkanı sağlayan ve hızla insanların hayatında
önemli yer edinen aygıtlardır. Cep telefonu kullanım oranındaki bu hızlı artış,
hizmet sağlayıcı olarak GSM operatörleri
arasındaki rekabeti büyük ölçüde arttırmıştır. GSM operatörleri de bu rekabet ortamından başarıyla
sıyrılabilmek için müşterilerini tatmin etmenin yolunu aramaktadır. Bu araştırmada cep telefonu kullanıcılarının GSM operatör
tercihleri tespit edilmeye çalışılmıştır. Bu bağlamda Diyarbakır’daki cep
telefonu kullanıcılarından 464 kişinin yüzyüze anket yöntemi çerçevesinde GSM opertörleri hakkındaki algıları
ölçülmeye çalışılmıştır. Elde edilen veriler istatistik paket programı aracı
ile Frekans ve Ki-Kare testlerine tabi
tutulmuştur. Demografik bulgular ile
tercih edilen GSM operatörleri arasında anlamlı ilişkinin var olup
olmadığı araştırılmıştır. Anlamlı ilişki bulunan verilere ait çapraz tablolar
ayrıntılı olarak incelenmiştir. Buna göre; katılımcıların daha çok faturalı hat
kullandıkları ve aylık görüşme bedeli olarak 26 tl-42tl arası bir harcama
yaptıkları görülmüştür. Katılımcılar için “Her Yöne Tarifeler” in daha fazla
ilgi çektiği görülmüştür. Operatör tercihlerinde en etkili unsur olarak tarife
ücreti uygunluğunu gören katılımcılar, daha sonra sırasıyla GSM Kalitesi ve Kampanyalar’ı önemsemektedirler.
Genç yaştakilerin operatör tercihinde öncelik kampanyayken, orta yaştakilerde
önceliğin GSM Kalitesi olduğu görülmüştür.
Life-Threatening Hemorrhage from an Unrecognized Axillary Vein Injury During Treatment of a Proximal Humeral Fracture-Dislocation with a Known Axillary Artery Injury
Authors: Githens Michael 
Published: May 2018

Case:
A 57-year-old man presented with bilateral proximal humeral fracture-dislocation and an associated axillary artery injury. He was treated urgently with reduction, arterial repair, fasciotomies, and skeletal stabilization. The patient sustained a massive intraoperative hemorrhage from an unrecognized axillary vein injury after the arterial repair.

Conclusion:
An unrecognized axillary vein injury led to substantial blood loss that required a massive transfusion protocol. Although an axillary arterial injury is readily identified with computed tomography angiography, concomitant venous injuries may go unrecognized. The surgical team, including the vascular and orthopaedic surgeons and the anesthesiologists, should be prepared to manage a life-threatening hemorrhage.
Isolated Iliac Crest Tuberculosis
Authors: Stingo Facundo E. , Rodriguez-Fontan Francisco , Burger-Van der Walt Evalina , Arce Javier , Garcia Sebastian N. , Munafo Ricardo M. 
Published: May 2018

Case:
Following an insidious onset of symptoms, a 29-year-old man who had no risk factors for tuberculosis was diagnosed with tuberculosis of the iliac crest. The red flag in this case was the patient’s progressive deterioration despite a variety of antibiotic regimens. Histopathologic demonstration of necrotic granulomatous inflammation and a positive culture led to the diagnosis. A combination of surgery and antitubercular-drug therapy resulted in clinical recovery.

Conclusion:
Iliac crest tuberculosis represents <1% of all skeletal tuberculosis cases. Even in the absence of classic symptoms and risk factors, orthopaedic surgeons should maintain a low threshold for tuberculosis in the differential diagnosis.
CONTAMINAÇÃO POR RESÍDUOS DE DISPAROS DE ARMAS DE FOGO: PERFIL DE VARIAÇÃO DOS CONTAMINANTES
Authors: Lisboa Wesley Machareth , De Assis Joaquim Teixeira , Carvalho Gil de , Zani Jose Humberto 
Published: May 2018

Um crescimento exponencial da violência tem sido assistido pela sociedade moderna em todo o mundo. Neste cenário, o emprego de armas de fogo (AF) está relacionado com a violência de uma forma significativa. Neste contexto, vários trabalhos científicos têm sido desenvolvidos com o objetivo de reduzir os índices de violência relacionada com armas de fogo e dando suporte aos trabalhos de investigação. O presente trabalho consiste na pesquisa para a identificação de resíduos de disparos de arma de fogo, Gunshot residues (GSR), que são depositados nas mãos dos atiradores. Foi utilizado um espectrômetro portátil de raios X, produzido pela AMPTEK, com tubo de raios X de anodo de Au. As amostras foram submetidas a um feixe com 15 e 25 kV de tensão e corrente de 15 e 25?A por um tempo de medida de 300s e 600s, respectivamente. Os espectros foram construídos com auxílio do programa DppMca, também fornecido pela AMPTEK. Os resultados obtidos através de amostras extraídas de atiradores e não atiradores mostraram que o uso da técnica de fluorescência de raios X por dispersão em energia (EDXRF) torna possível identificar elementos característicos de disparos de armas de fogo, GSR.
DIMENSIONAMENTO DE SEDIMENTADORES CONTÍNUOS COM BASE NA MODELAGEM MATEMÁTICA DA SEDIMENTAÇÃO EM PROVETA
Authors: Da Silva Vânia Queiroz , Carvalho Rosilanny Soares , Dias Lorena Lopes , Veloso Stephanie Froes 
Published: May 2018

Sedimentadores contínuos são equipamentos muito utilizados em indústrias químicas, de beneficiamento de minério e em estações de tratamento de água e efluentes. Esses promovem a separação entre sólidos e líquidos com base na diferença entre as densidades das fases presentes, sujeitas à ação do campo gravitacional. A utilização de modelos matemáticos para a simulação, projeto e o controle de sedimentadores é de fundamental importância, uma vez que são de grande interesse teórico, prático e econômico. Neste contexto, o presente trabalho tem como objetivo determinar um modelo matemático para o dimensionamento de sedimentadores para uma vazão pré-estabelecida com base no método de Método de Biscaia Jr. por meio de um teste de proveta para simular a sedimentação. A metodologia foi feita com base no teste de proveta, utilizando-se cinco diferentes concentrações iniciais de solução de carbonato de cálcio, (18,8; 24,8; 29,1; 47,0; 74,4 Kg/m³), com isso, calculou-se a área e a altura do sedimentador em cada condição operacional e desenvolveu-se um modelo matemático para as dimensões de um sedimentador com base no modelo proposto por Biscaia Jr. O modelo matemático obtido se mostrou eficaz na determinação das dimensões de sedimentadores que operem no intervalo de concentrações estudado no presente trabalho.
SIMULAÇÃO DO MODELO EPIDEMIOLÓGICO SIR UTILIZANDO A FERRAMENTA XCOS DO SOFTWARE LIVRE SCILAB
Authors: Veloso Stephanie Froes , Da Silva Vânia Queiroz , Gulberto Leite Neila Marcelle , Santos Maria Nayara Pontes , Teixeira Victor Pádua 
Published: May 2018

A medicina e a matemática deixaram de ser áreas de estudo isoladas e atualmente são desenvolvidas de maneira a solucionar e desenvolver modelos que atendam a sociedade como um todo. A utilização de modelos matemáticos na epidemiologia é de fundamental importância uma vez que são úteis no desenvolvimento de estratégias de contenção de epidemias. As soluções de alguns desses modelos são complexas, obtidas muitas vezes por meio de recursos computacionais. Nesse sentido, o presente trabalho tem como objetivo a simulação do modelo SIR (Susceptível-Infectado-Removido) para o sistema epidemiológico da influenza A H1N1, por meio da utilização da ferramenta Xcos acoplada ao Scilab, em continuação ao trabalho realizado para o modelo SI. Para a metodologia utilizou-se os dados disponibilizados pelo site da Secretaria de Vigilância em Saúde que correspondem à quantidade de indivíduos brasileiros que foram diagnosticados com Síndrome Respiratória Aguda Grave (SRAG). O intervalo de tempo de estudo foram as 20 primeiras semanas do ano de 2013 devido ao maior índice de propagação do vírus Influenza A H1N1 no Brasil. Este trabalho obteve como resultado que o Xcos é uma ferramenta adequada para simulação de modelos mais complexos como o SIR, uma vez que os resultados obtidos estão bem próximos dos dados reais fornecidos pelo boletim epidemiológico disponível pelo Portal da Saúde. Além disso, comprovou-se que o Xcos é de fácil manipulação, bastante didático, de bom desempenho e de domínio público o torna uma ferramenta ainda mais satisfatória.
A generalized model for pumping well hydraulics in confined aquifers
Authors: Anwar Shadab 
Published: May 2018

AbstractA generalized model for well hydraulics in confined aquifers is presented. The lattice Boltzmann method (LBM)-based altered-velocity model is used to simulate well hydraulics in homogeneous and heterogeneous confined aquifers for different pumping conditions. LBM is applied to simulate well hydraulics in two different configurations of heterogeneous aquifer, where (1) a circular disk of material or (2) an infinite linear strip of material is embedded in a matrix of differing hydraulic properties. The effect of hydrogeologic boundaries on drawdown curve in confined aquifers is simulated using LBM. The LBM is further applied to simulate drawdown during harmonic pumping well test. The LBM data in lattice units are scaled to physical units using non-dimensional discharge rate and diffusion length. The results from LBM were found to be sensitive to the relaxation parameter and the RMS error for drawdown was found to be less than 1% for later time. This work will verify the potential of LBM to simulate well hydraulics in homogeneous and heterogeneous confined aquifers for constant, step, and harmonic pumping.
Recent Advances in Nanosuspension Technology for Drug Delivery
Authors: Arora Daisy , Khurana Bharat , Rath Goutam , Nanda Sanju , Goyal Amit K. 
Published: May 2018

Background:
Discovery and development of BCS class 1 drugs through high throughput screening is
one of the biggest challenge faced by formulation scientist.

Methods:

There are a number of approaches that have been exploited to enhance the solubility and permeability
of drugs. Among them, development of nanosuspension has offered several benefits. These techniques may increase
effective surface area due to nanonization of drug particles and further increases saturation solubility and
dissolution properties for improved bioavailability. Various development methods are patented which are cost
effective and easy to scale up.

Conclusion:

Several unique features of nanosuspension make it a versatile delivery system for different routes of
administration including oral, dermal, ocular, parenteral and pulmonary. The present review is focused on preparatory
techniques and formulation considerations of nanosuspension. Brief information about evaluation parameters,
applications of nanosuspension in drug delivery and patented and marketed products available is also
discussed.
Cocrystal and its Application in the Field of Active Pharmaceutical Ingredients and Food Ingredients
Authors: Wang Na , Xie Chuang , Lu Haijiao , Guo Nannan , Lou Yajing , Su Weiyi , Hao Hongxun 
Published: May 2018

Background:
The development of solid drug dosage form and food ingredients is constrained by their
low solubility, low dissolution, low bioavailability and poor physicochemical properties. Formation of cocrystal is
a novel and promising method to enhance and improve the properties of materials without breaking the covalent
bonds.

Methods:
The goal of this review is to summarize the cocrystals and their applications in the field of Active
Pharmaceutical Ingredients (APIs) and food ingredients (AFIs), mainly on the effective improvements of APIs’
and AFIs’ pharmacokinetic, physicochemical and mechanical properties by the formation of cocrystals.

Results:
After years of research and development on cocrystals in the area of pharmaceutical and food industries,
significant progress has been made. Formation of cocrystal is an efficient method for improving the solubility,
dissolution rate, permeability and in vivo bioavailability of APIs and AFIs, as well as for enhancing stability and
mechanical properties.

Conclusion:
Cocrystals exhibit complex structures which can conspicuously affect the physical and chemical
properties of original substance, with good clinical performance and outstanding stability during processing and
storage.
Application of Traditional Chinese Herbal Medicine By-products as Dietary Feed Supplements and Antibiotic Replacements in Animal Production
Authors: Abdallah Abedin , Zhang Pei , Zhong Qingzhen , Sun Zewei 
Published: May 2018

Background:Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is Traditional Chinese Herbal Medicine (TCHM). These herbs contain several but less toxic bioactive compounds which are generally regarded as biodegradable. Recently, advances in the knowledge of the importance of TCHM have led to a rapid increase in its production and hence, increasing the amount of by-products generated. Such by-products have become a serious environmental challenge because producers regard them as industrial waste and discard them directly. This review summarizes scientific findings on the bioactive compounds in TCHM and TCHM by-products, discusses functional dietary patterns and outlines challenges that may hinder full utilization of TCHM by-products in animal production.Methods:Information for this review was obtained through scientific databases and websites such as Pubmed and Google scholar from 2004 to 2017 using experimental studies on bioactive compounds in TCHM and their effects in animal production.Results:Studies have shown that TCHM by-products contain high amounts of bioactive compounds which confer several nutritional and health benefits to animals and thus could be incorporated as feed additives.Conclusion:The findings for this review indicate that TCHM by-products apart from being a good alternative for synthetic antibiotics could also minimize the current environmental challenges associated with its disposal.
Supramolecular Solvent Based Liquid-Liquid Microextraction for Preconcentration of Selected Fluoroquinolone Antibiotics in Environmental Water Sample Prior to High Performance Liquid Chromatographic Determination
Authors: Selahle Shirley K. , Nomngongo Philiswa N. 
Published: May 2018

Background and Objective:
A rapid, simple and environmental friendly supramolecular
solvent (SUPRAS) based liquid-liquid microextraction method for preconcentration of ciprofloxacin
(CIPRO), danofloxacin (DANO) and enrofloxacin (ENRO) from wastewater was developed.

Methods:
This microextraction technique was coupled with high-performance liquid chromatography
equipped with a diode array detector (HPLC-PDA) for detection and separation of the antibiotics. The
SUPRAS composed of decanoic acid and tricaprylymethylammonium chloride. Optimum conditions for
the extraction and preconcentration of all the antibiotics were obtained using surface response methodology
(RSM) based on Box-Behnken design.

Results:
Under optimum conditions, the limits of detection (LOD) and limit of quantification (LOQ)
ranged from 0.06-0.14 µg L−1 and 0.22-0.47 μg L−1, respectively with the preconcentration factors ranging
from 153-241. The linear dynamic ranges were between LOQ and 850 µg L−1 with correlation coefficients
ranging from 0.9928 to 0.9999. The intra-day (n = 15) and inter-day (n = 5) precisions (expressed
in terms of %RSD) for 50 µg L−1 of CIPRO, DANO and ENRO were in the range of 3.3–4%
and 4.1–5.8%, respectively.

Conclusion:
Lastly, the developed method was used for the extraction, preconcentration and quantification
of selected CIPRO, DANO and ENRO in influent and effluent wastewater samples.
Development of an HPLC-UV Method for Quantification of Stattic
Authors: Sedaghat Soheil , Molavi Ommoleila , Faridi Akram , Shayanfar Ali , Rashidi Mohammad Reza 
Published: May 2018

Background:
Signal transducer and activator of transcription 3 (STAT3), an oncogenic protein
found constitutively active in many types of human malignancies, is considered to be a promising
target for cancer therapy.

Objective:
In this study for the first time, a simple and accurate method has been developed for the determination
of a STAT3 dimerization inhibitor called stattic in aqueous and plasma samples.

Methods:
A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18
column as stationary phase, and the mixture of acetonitrile (60%) and water (40%) as mobile phase with
a UV detection at 215 nm were applied for quantification of stattic. The developed method was validated
by Food and Drug Administration (FDA) guideline.

Results:
The method provided a linear range between 1-40 and 2.5-40 µg mL-1 for aqueous and plasma
samples, respectively, with a correlation coefficient of 0.999. The accuracy (as recovery) of the developed
method was found to be between 95-105% for aqueous medium and 85-115% for plasma samples.
The precision (as relative standard deviation) for aqueous and plasma samples was less than 6% and
15%, respectively. The sensitivity of the developed method based on FDA guideline was 1 µg mL-1 for
aqueous and 2.5 µg mL-1 for plasma samples.

Conclusion:
These results show that the established method is a fast and accurate quantification for
stattic in aqueous and plasma samples.