bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Delivery of Anticancer Agents Using Nanoparticulate Drug Delivery System
Authors: Mathur Prateek , Rawal Shruti , Patel Bhoomika , Patel Mayur M. 
Published: October 2019

Background:Conventionally, anti-cancer agents were administered through the intravenous route. The major drawbacks associated with the intravenous route of administration are: severe side effects, need of hospitalization, nursing care, and palliative treatment. In order to overcome the drawbacks associated with the intravenous route of administration, oral delivery of anti-cancer agents has gained tremendous interest among the scientific fraternity. Oral delivery of anti-cancer agents principally leads to a reduction in the overall cost of treatment, and aids in improving the quality of life of patients. Bioavailability of drugs and inter-subject variability are the major concerns with oral administration of anti-cancer agents. Factors viz. physicochemical and biological barriers (pre-systemic metabolism and transmembrane efflux of the drug) are accountable for hampering oral bioavailability of anti-cancer agents can be efficiently overcome by employing nanocarrier based drug delivery systems. Oral delivery of anticancer agents by employing these drug delivery systems will not only improve the quality of life of patients but will also provide pharmacoeconomic advantage and lead to a reduction in the overall cost of treatment of life-threatening disease like cancer.Objective:This article aims to familiarize the readers with some of the recent advancements in the field of nanobased drug delivery systems for oral delivery of anticancer agents.Conclusion:Advancement in the field of nanotechnology-based drug delivery systems has opened up gateways for the delivery of drugs that are difficult to administer orally. Oral delivery of anti-cancer agents by these drug delivery systems will not only improve the quality of life of patients but will also provide pharmacoeconomic advantage and lead to a reduction in the overall cost of treatment of life-threatening disease like cancer.
Virulence Factors in Sporothrix schenckii, One of the Causative Agents of Sporotrichosis
Authors: Tamez-Castrellón Alma K. , Romeo Orazio , García-Carnero Laura C. , Lozoya-Pérez Nancy E. , Mora-Montes Héctor M. 
Published: October 2019

:
Sporothrix schenckii is one of the etiological agents of sporotrichosis, a fungal infection
distributed worldwide. Both, the causative organism and the disease have currently received limited
attention by the medical mycology community, most likely because of the low mortality rates associated
with it. Nonetheless, morbidity is high in endemic regions and the versatility of S. schenckii to
cause zoonosis and sapronosis has attracted attention. Thus far, virulence factors associated with this
organism are poorly described. Here, comparing the S. schenckii genome sequence with other medically
relevant fungi, genes involved in morphological change, cell wall synthesis, immune evasion,
thermotolerance, adhesion, biofilm formation, melanin production, nutrient uptake, response to stress,
extracellular vesicle formation, and toxin production are predicted and discussed as putative virulence
factors in S. schenckii.
Neonatal Immune Activation May Provoke Long-term Depressive Attributes
Authors: Schelder-Marzzani Simone H. , Dias Paula , Freiberger Viviane , Ventura Letícia , Silva Bruna B. , Dutra Matheus L. , Bobinski Franciane , Schlindwein Aline D. , Cassol Omar J. , Comim Clarissa M. 
Published: October 2019

Background:Studies have shown the relationship between neuroinflammation and depressive- like parameters. However, research still has not been carried out to evaluate neuroinflammation in the neonatal period and psychiatric disorders in adulthood.Objective:To verify the association between neonatal immune activation and depressive-like parameters in adulthood using an animal model.Methods:Two days old C57BL/6 animals were exposed to lipopolysaccharides (LPS) or phosphate- buffered saline (PBS). When the animals were 46 days old, they received PBS or Imipramine at 14 days. At 60 days, the consumption of sucrose; immobility time; adrenal gland and the hippocampus weight; levels of plasma corticosterone and hippocampal Brain-derived neurotrophic factor (BDNF) were evaluated.Results:It was observed that the animals exposed to LPS in the neonatal period and evaluated in adulthood decreased the consumption of sucrose and had reducted hippocampus weight. Also, the exposed animals presented an increase of immobility time, adrenal gland weight and plasma levels of corticosteroids. The use of imipramine did not only modify the decreased hippocampal weight. On the other hand, there were no alterations in the BDNF levels in the hippocampus with or without the use of imipramine.Conclusion:These results suggest that neonatal immune activation may be associated with depressive- like parameters in adulthood. It is believed that endotoxemia may trigger physiological and behavioral alterations, increasing vulnerability for the development of depression in adulthood.
Etiological Features of Liver Involvement in Rheumatoid Arthritis
Authors: Sellami Meriem , Saidane Olfa , Mahmoud Ines , Tekaya Aicha Ben , Tekaya Rawdha , Abdelmoula Leila 
Published: October 2019

Background:
Liver involvement is not considered a typical extra-articular manifestation
and has rarely been studied in rheumatoid arthritis (RA).

:
We aimed to identify the prevalence and aetiologies of liver disease in RA patients.

Methods:
A cross-sectional study included 150 patients with RA enrolled over 5 years (2010-
2015). The clinical and paraclinical features of RA were analyzed. The clinical and biological characteristics
of liver impairment and its aetiologies were collected.

Results:
One hundred and fifty RA patients (124 women) with a mean age of 57.09 years and a
mean RA duration of 7.52 years were included. Liver involvement was diagnosed in 66 patients
(44%). The liver disease was asymptomatic in 94% of the cases, revealed by increased gammaglutamyl
transferase levels in 74% of the patients. The aetiologies of liver involvement were hepatotoxicity
of medications in 38 cases (57%), hepatitis B and C in 14 patients (21%), fatty liver disease
in 10 cases (15%), autoimmune liver disease in 2 patients (3%), hydatid cyst in 1 case (2%),
and liver angiomas in 1 case (2%). Non-steroidal anti-inflammatory drugs and methotrexate were
the drugs most often involved in the genesis of hepatotoxicity (21% and 20% of the cases, respectively).

Conclusion:
Liver involvement occurred in 44% of RA patients. Aetiologies were mainly hepatotoxicity
and viral hepatitis B and C. Patients with RA should be systematically screened for liver
disease, which is rarely symptomatic.
A ADVOCACIA PÚBLICA COMO INSTITUIÇÃO ESSENCIAL AO ESTADO DE DIREITO DEMOCRÁTICO E SOCIAL
Authors: Santos Marcus Gouveia dos 
Published: October 2019

O presente artigo tem como objeto a função constitucional da Advocacia Pública, pretendendo demonstrar a sua natureza de princípio garantia para a consolidação dos princípios estruturantes do Estado de Direito Democrático e Social. Para alcançar este propósito, formularam-se os seguintes objetivos: a) analisar a trajetória histórica de reconhecimento do Estado de Direito Democrático e Social na Constituição; b) analisar o percurso histórico e as respectivas funções da Advocacia Pública no Estado de Direito; c) demonstrar as consequências da adoção do Estado de Direito Democrático e Social como princípio estruturante da Constituição Brasileira, considerando, entre outros aspectos, a influência sobre a concretização da dignidade da pessoa humana. Do ponto de vista metodológico, desenvolveu-se pesquisa descritiva, cujas fontes principais foram: a Constituição Brasileira, a legislação nacional e a doutrina produzida por juristas de diferentes países, que trazem a lume alguns consensos e divergências quanto à função constitucional da Advocacia Pública para a consolidação dos princípios estruturantes. Ao final, apresentam-se considerações no intuito de contribuir para a garantia dos princípios constitucionais estruturantes, por meio de uma concepção constitucionalmente adequada do papel da Advocacia Pública.
Estimasi Nilai Ekonomi Obat Tidak Digunakan pada Kalangan Rumah Tangga Kota Yogyakarta
Authors: Ridwan Bai Athur , Kristina Susi Ari , Wiedyaningsih Chairun 
Published: October 2019

Pengeluaran untuk obat-obat yang diresepkan dan obat yang dijual bebas merupakan persentase besar dari total biaya perawatan kesehatan. Pasien mungkin tidak dapat menggunakan semua obat yang diperoleh dari pengobatan karena perubahan dosis atau obat-obat yang telah kedaluwarsa. Hal ini diperkirakan memiliki konsekuensi terhadap finansial. Tujuan utama dari penelitian ini adalah untuk mengetahui nilai ekonomi obat tidak digunakan dan kedaluwarsa pada kalangan rumah tangga Kota Yogyakarta.Jenis Penelitian ini yaitu observatif dengan rancangan studi cross sectional. Responden dipilih secara convenience sampling dan diwawancara langsung dan mendata obat-obat yang disimpan di rumah. Data dianalisis dan dipersentasikan secara deskriptif.Dari 400 responden, hanya 261 (65,2%) yang menyimpan obat terdiri dari obat sedang digunakan dan persediaan, obat tidak digunakan dan obat kedaluwarsa dengan total harga sebesar Rp7.082.556. Total harga obat tidak digunakan sebesar Rp1.273.921 (18%) dengan rata-rata Rp13.698 per orang sedangkan obat kedaluwarsa hanya berharga Rp140.065 (2%) dengan rata-rata Rp12.733. Berdasarkan kelas terapi, jumlah obat tidak digunakan paling banyak adalah analgesik (28,6%), sistem respirasi (13,7%), dan antimikroba (11,9%), sedangkan obat kedaluwarsa utamanya analgesik, saluran cerna dan antiseptik masing-masing (18,8%). Nilai ekonomi obat tidak digunakan dan kedaluwarsa pada kalangan rumah tangga dari penelitian ini relatif kecil. Penelitian ini dapat berfungsi dalam program edukasi masyarakat untuk meningkatkan kepatuhan dan penggunaan obat secara tepat dan efisien agar dapat dilakukan penghematan biaya kesehatan yang dikeluarkan.Kata Kunci: Obat tidak digunakan, obat kedaluwarsa, biaya
Reflexiones metodológicas en torno al estudio de las Representaciones Sociales. Su relevancia para la investigación educativa
Authors: Gutiérrez-Vidrio Silvia 
Published: October 2019

En el campo de estudio de las representaciones sociales es común encontrar trabajos que incorporan el concepto y la teoría de manera poco sistemática, o en los que existe cierta confusión nocional e inconsistencia investigativa. Al respecto, en este texto presento algunas reflexiones y recomendaciones sobre elementos claves que necesitan reunir las investigaciones en este campo, con el fin de que las personas interesadas en esta propuesta y en su aplicación en la investigación educativa, puedan diseñar e implementar investigaciones de manera sólida. Los contenidos se articulan en tres nudos problemáticos: la construcción del objeto de investigación y la elección de los sujetos que la comparten, los enfoques teórico-metodológicos que marcan los diferentes abordajes que siguen los estudios empíricos y los métodos de acopio y análisis más utilizados.
Instant Corn Rice Product Development
Authors: Hidayat Khoirul , Mu'tamar Mohammad Fuad Fauzul , Firmansyah R Arief , Illahi Wahyudi 
Published: October 2019

The Madurese consumes corn as the primary source of carbohydrates. However, currently, they are experiencing a shift in consumption from corn to rice. It is caused by the availability of abundant rice. Moreover, another reason is the process of processing corn requires a relatively long time. The purpose of this research is to develop instant Madura corn rice. The method used in this research is the Quality Function Deployment (QFD) method. Based on the House of Quality matrix obtained 16 attributes of consumer needs both in terms of products and packaging. Highest Attributes of the needs of consumers are attributes without preservatives for the product aspect and presenting attributes for the packaging aspect. There are 17 attributes of technical requirements needed to meet the attributes of consumer needs. Highest priority The technical requirements are the corn type attribute for the product side and the font-size attribute for the packaging aspect. The results of product comparisons with competitors, Madura corn rice products have advantages in the yellow color attribute. Furthermore, It needs to be improved attributes about the texture a little soft.
Comercio informal en el espacio publico del barrio San Isidro en Villavicencio, Meta Colombia. Legalización ¿realidad o utopía?
Authors: Castro Garzón Hernando , Romero Rincón Yuri Yaneth , Sarmiento Suarez Karol Liceth 
Published: October 2019

El fenómeno de la informalidad se ha destacado como uno de los factores que incide en el mercado laboral de Colombia y el mundo, no solo por su efecto dentro de la economía, si no a raíz de su acelerado crecimiento.
El presente trabajo está dirigido a identificar los principales motivos de permanencia de los comerciantes informales en las calles del barrio San Isidro, donde funcionó la plaza de mercado municipal, en la ciudad de Villavicencio, Colombia. Lo anterior, ha sido producto de una década de fracasos por parte de la institucionalidad sin que se conozca aún la decisión sobre el ordenamiento de esta zona; generando un inadecuado manejo y disposición de residuos orgánicos así como la invasión del espacio público. Adicionalmente, se ha demostrado que soluciones coyunturales como el desalojo de los puestos de trabajo sólo trae violencia en los lugares donde es llevado a cabo.
Por consiguiente, la permanencia está dada en términos de: nivel de ingresos, horarios flexibles, autonomía, experiencia y conocimiento del mercado; adicionando que la formalización no está considerada como una alternativa viable de ejercer el comercio.
Análisis del riesgo financiero y riesgo de salud para las enfermedades de alto costo en una EPS de la ciudad de Bucaramanga año 2018
Authors: Almeida Espinosa Alexander , Castro Mendez Wilson 
Published: October 2019

Introducción: Las enfermedades de alto costo se han convertido hoy en di a en un determinante e indicador de perdurabilidad, calidad y prestación de servicios de salud en las empresas promotoras de salud (Eps) de la ciudad de Bucaramanga. Sumado a esto, el alto costo viene creciendo en esta ciudad de forma descontrolada, debido a que las personas no están siguiendo condiciones de hábitos de vida saludables y controles eficientes de salud, que son recomendados según su esquema de salud, cuadro clínico y factores de salud identificados. Todo esto repercute de forma negativa en la prestación de servicios de salud, ya que ocasiona un costo administrativo mayor que conlleva el amparo y prestación con calidad de esquemas de salud para combatir la mitigación de factores y la misma enfermedad de alto costo. Objetivo: analizar el riesgo financiero y de salud de las enfermedades des alto costo en una eps de la ciudad de Bucaramanga en el año 2018. Metodología: estudio descriptivo, transversal, prospectivo con enfoque cuantitativo. Conclusiones. Las enfermedades de alto costo colocan en riesgo financiero – administrativo las eps de la ciudad de Bucaramanga debido al costo elevado que se debe tener para la mitigación de las mismas y mejorar la calidad de vida de los usuarios.
Studi Kualitatif Fenomenologis: Motivasi Memakai Hijab Modis pada Mahasiswa
Authors: Atmawati Fitri Dwi , Permadi Aad Satria 
Published: October 2019

Hijab merupakan pakaian yang wajib dipakai oleh wanita muslimah.Seiring perkembangannya, hijab tidak lagi dipandang pakaian serba tertutup yang menggambarkan kesan tradisional, monoton dan kuno. Hijab hadir dengan bermacam-macam bahan, warna dan aksesoris sehingga penggunaan hijab tidak hanya sebatas perintah agama untuk menutup aurat, namun juga sebagai simbol wanita muslimah yang mengikuti trend. Universitas Muhammadiyah Surakarta memiliki peraturan yang ditujukan kepada mahasiswa untuk memakai pakaian yang sesuai dengan norma kesopanan, kesusilaan, dan ajaran agama Islam, akan tetapi, banyak mahasiswa yang memakai pakaian yang ketat maupun terawang sehingga menggambarkan bentuk tubuh.Penelitian kualitatif ini mempunyai tujuan untuk mendeskripsikan motivasi yang dimiliki oleh mahasiswa Universitas Muhammadiyah Surakarta dalam memakai hijab modis. Informan penelitian sebanyak 6 orang yang dipilih secara purposive sampling yaitu mahasiswa Universitas Muhammadiyah Surakarta yang memakai hijab modis dengan rentang usia 19 - 25 tahun. Teknik analisis data terdapat beberapa tahap yaitu: a) pengumpulan data, b) tahap reduksi data, c) tahap display data, d) tahap penarikan kesimpulan. Hasil penelitian menunjukan bahwa motivasi dipengaruhi oleh faktor intrinsik yaitu kurangnya pemahaman terhadap aturan memakai hijab, ketidaksiapan memakai pakaian syar’i, dan rasa nyaman, serta faktor ekstrinsik yaitu konformitas, kebebasan dari orang tua, model pakaian yang bervariasi dan reinforcement berupa pujian.
Transfemoral transcatheter aortic valve replacement in the presence of a mitral prosthesis
Authors: Toutouzas Konstantinos , Drakopoulou Maria , Latsios George , Synetos Andreas , Stathogiannis Konstantinos , Soulaidopoulos Stergios , Oikonomou George , Trantalis George , Papanikolaou Aggelos , Aggeli Constantina , Vavuranakis Manolis , Mastrokostopoulos Antonis , Katsimaglis George , Voudris Vassilis , Dardas Petros , Tousoulis Dimitris 
Published: October 2019

PurposeIn the current case series, we present our experience with the self-expanding CoreValve or Evolut R (Medtronic Inc.) in patients with severe symptomatic aortic valve stenosis and concomitant mitral valve prosthesis.MethodsTwelve patients with previous mitral valve prosthesis underwent transcatheter aortic valve replacement for severe symptomatic aortic valve stenosis and/or aortic valve regurgitation. All patients underwent evaluation with an echocardiogram, computed tomography and coronary angiogram. After the index intervention and before discharge all patients underwent transthoracic echocardiography. All outcomes were defined according to the Valve Academic Research Consortium-2 criteria.ResultsEleven patients underwent transcatheter aortic valve replacement for severe symptomatic aortic valve stenosis and one patient for severe aortic valve regurgitation. There was immediate improvement of patients’ hemodynamic status; no cases of procedural death, stroke, myocardial infarction, or urgent cardiac surgery occurred. There was no 30-day mortality and all patients improved, with 91.6% in functional New York Heart Association class I–II.ConclusionThe current study demonstrates that in patients with severe aortic valve stenosis or regurgitation and mitral valve prosthesis, the implantation of a self-expanding aortic valve via the transfemoral route is safe and feasible, with maintained long-term results.
LAKON PUNAKAWAN DALAM KARYA FOTOGRAFI SENI
Authors: Rosa Gea , Wulandari Arti , Samaratungga Oscar 
Published: October 2019

Abstrak Penciptan karya seni ini bermula dari keprihatinan terhadap pementasan wayang yang sudah mulai ditinggalkan di era milenial ini, sangat disayangkan apaila pementasan tersebut hilang begitu saja. Padahal kesenian ini sangat banyak memberikan pelajaran yang dapat membentuk karakter generasi muda menjadi lebih baik. Sebagai seorang yang lahir dan besar di Jawa, berkewajiban untuk turut andil dalam melestarikan kesenian peninggalan nenek moyang ini. Penciptaan karya seni ini mengambil tokoh Punakawan yang beranggotakan Semar, Gareng, Petruk dan Bagong. Tokoh-tokoh wayang tersebut diambil karena perannya dalam dunia pewayangan sangat besar. Penciptaan karya seni ini memvisualkan cuplikan lakon Punakawan ke dalam karya fotografi seni. Selain itu, ingin menyampaikan pesan moral yang terdapa dalam lakon Punakawan di karya fotografi seni. Karya visual ini mengandung elemen-elemen pendukung sesuai dengan topik yang diangkat. Elemen-elemen tersebut digabungkan dengan teknik montase yang diproses menggunakan digital imaging dan dicetak di media kertas foto. Dengan demikian, visual yang dihadirkan sesuai dengan harapan dan pesan yang akan disampaikan bisa tersampaikan dengan baik. Kata kunci : lakon, Punakawan, fotografi seni Abstract Punakawan Play in Fine Art Photography. The creation of this art work originated from the concern about puppet showa that already abandoned in this millenial era. It is unfortunate if the show just disappear. Exen trough this art provides a lot of knowledge that can estabilish young generation character to be better. As a person born and raised in Java, emerged a sense of having an obligation to take part in perserving traditional arts. The creation of this art work takes in the figure of a slownman who consist of Semar, Gareng, Petruk and Bagong. The Puppet caracter is taken, because of the role in the world of puppetry is very large. The creation of this artwork visualizes snoppet of the clown. Storie into photographic artwork. Moreover, want to convey a moral message contained in the storie of clowns into photography artwork. The creation contain elemens that supporting as compatible as the topic raised. The elements combaineed with montage technique that proceeded using digital imaging and printed on photo paper, so the visual that served consistent to the hope. Also the message delivered,conveyed well. Keywords: Punakawan, play, fine art photography
New Trends in Israel Regional Policy (2009-2019)
Authors: Karasova T. A. 
Published: October 2019

Changes in Israeli regional politics were triggered by the current political situation in the Middle East, characterized by a high degree of intensity and unpredictability. The region experiences a complex process of serious political changes making Israel adjust its regional policy to the new challenges. The article focuses upon the new elements of Israelis strategy on key regional issues: the settlement of Palestinian-Israeli conflict; new approaches to countering Iranian nuclear program; the Syrian civil war and escalation of terrorism activities. The aim of the article is to describe and analyze new trends in Israeli regional strategy over the past 10 years identifying its external and internal factors. The main external factor is a close partnership of Israel with US, which plays a key role in supporting Israel’s regional and international status. The changes taking place inside the region could be considered as internal factors. They include Arab Spring; prospects for settlement of the Palestinian-Israeli conflict; the growth of the Islamic radicalism and terrorism, new terrorist groups such as ISIS, and the civil war in Syria.The main changes of Israeli regional policy include toughening approaches to resolving the Palestinian-Israeli conflict, in particular, de facto abandonment of the «two states for two peoples» formula. Equally important are events that, although not directly related to Israel, are changing its regional agenda. Assessment of Iran’s nuclear program as an existential threat explains Israel’s negative attitude to the international agreement with Iran in 2015 during the presidency of B. Obama (JCPOA). The subsequent withdrawal of the Trump administration from this agreement strengthened Israel’s anti-Iranian position. This also allowed Israel to develop cooperative ties with the so-called pro-Western states of the region, such as Saudi Arabia and some Persian Gulf countries in pursuit of containing the Iranian nuclear threat and its growing regional influence. Saudi Arabia and the Gulf countries became real partners of Israel in confronting Iran. This gives the Israeli state the opportunity to at last enter the regional system and free itself from the traditional image of rogue state among the Muslim countries in the Middle East.