bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brachytherapy for Soft Tissue Sarcoma: Maintaining Local Control While Minimizing Complications
Authors: Montreuil Julien , Kholodovsky Eric , Markowitz Moses , Torralbas Fitz Sergio , Campano Dominic , Geiger Erik , Hornicek Francis , Crawford Brooke , Keisch Martin , Temple H. Thomas 
Published: November 2024

ABSTRACTBackgroundThis study aims to assess the clinical and oncologic outcomes of high‐dose brachytherapy (BRT) versus both preoperative and postoperative external beam radiation therapy (EBRT) in the setting of high‐grade soft tissue sarcoma.MethodsThis is a retrospective cohort study of 144 patients treated surgically for soft tissue sarcoma at the same institution from 2010 to 2021. Patients treated for a soft tissue sarcoma with surgery and radiation therapy in the form of BRT, Neoadjuvant EBRT (Neo‐EBRT) or adjuvant EBRT (AD‐EBRT) were included.Results56 patients were treated with BRT, 42 with Neo‐EBRT, and 46 with AD‐EBRT. There was a greater incidence of grouped wound complications in Neo‐EBRT with 50% compared to both BRT with 25% and AD‐EBRT with 28.3% (p = 0.02). Univariate and multivariate analysis showed that there was an increased risk of wound complications with Neo‐EBRT when compared to brachytherapy (p = 0.03 and p = 0.007, respectively). Univariate and multivariate analysis showed that there was no difference in risk of LR between treatment groups (p = 0.28).ConclusionBrachytherapy is a valuable treatment modality that offers clinical and logistical advantages when compared to the conventional Neo‐EBRT in soft tissue sarcomas. Brachytherapy offers a lower risk of wound complications and a comparable local control. This manuscript presents decision‐making strategies for determining the appropriate radiation modality for specific circumstances.
Artificial Vegetation Restoration Enhances Soil Fertility and Microbial Network Complexity in Eroded Areas
Authors: Wang Xiaopeng , Zhou Man , Tan Zechuang , Wang Zumei , Lin Gengen , Zhang Yue , Jiang Fangshi , Huang Yanhe , Lin Jinshi 
Published: November 2024

ABSTRACTAlthough artificial vegetation restoration measures decelerate soil erosion, the impacts on soil microbial communities and soil fertility remain unclear. This impedes our ability to assess the true effects of artificial vegetation restoration measures on degraded soil ecosystems. To address this issue, we used vegetation restoration plots in severely eroded areas in China as research objects and applied high‐throughput sequencing technology to determine the composition of the soil bacterial and fungal communities. Compared with eroded sites, artificial vegetation restoration plots not only presented greater microbial diversity and network complexity but also presented increased resistance to environmental stress. Artificial vegetation restoration measures altered the microbial community composition by increasing the content of soil alkali‐hydrolyzable nitrogen, reducing the relative abundance of dominant microbes such as Chloroflexi and Ascomycota. Changes in microbial community characteristics were closely associated with variations in a comprehensive index of soil fertility induced by artificial vegetation restoration measures. In summary, these results indicate that artificial vegetation restoration measures have significant positive impacts on the rehabilitation of degraded soil ecosystems.
Postionization Mass Spectrometry Imaging: Past, Present, and Future
Authors: Guan Xiaokang , Lu Qiao , Liu Shuxian , Yan Xiaowen 
Published: November 2024

ABSTRACTMass spectrometry imaging (MSI) technologies are widely used today to study the in situ spatial distributions for a variety of analytes. As these technologies advance, the pursuit of higher resolution in MSI has intensified. The limitation of direct desorption/ionization is its insufficient ionization, posing a constraint on the advancement of high‐resolution MSI technologies. The introduction of postionization process compensates the low ionization efficiency caused by sacrificing the desorption area while pursuing high spatial resolution, resolving the conflict between high spatial resolution and high sensitivity in direct desorption/ionization method. Here, we discuss the sampling and ionization steps of MSI separately, and review the postionization methods in MSI according to three different sampling modes: laser sampling, probe sampling, and ion beam sampling. Postionization technology excels in enhancing ionization efficiency, boosting sensitivity, mitigating discrimination effect, simplifying sample preparation, and expanding the scope of applicability. These advantages position postionization technology as a promising tool for biomedical sciences, materials sciences, forensic analysis and other fields.
The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells
Authors: Garcia‐Vicién Gemma , Ruiz Núria , Micke Patrick , Ruffinelli José Carlos , Mils Kristel , Bañuls María , Molina Natalia , Pardo Miguel A. , Lladó Laura , Mezheyeuski Artur , Molleví David G. 
Published: November 2024

AbstractColorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter associated with worst prognosis. This study aimed to investigate the tumor microenvironment (TME) between HGPs supporting different survival. Multiplexed immunohistochemical staining was performed with the Opal7 system in a 100‐patients cohort to evaluate the tumor–liver interface with three different cell panels: lymphoid, myeloid, and carcinoma‐associated fibroblasts. Differences between HGPs were assessed by Mann–Whitney U test with Pratt correction and Holm–Bonferroni multitest adjustment. Cytotoxic T‐cells were more abundant in tumoral areas of dHGP, while non‐dHGP had higher macrophages infiltration, Th2, CD163+, and Calprotectin+ cells as well as higher pSMAD2 expression. Regarding carcinoma‐associated fibroblasts, several subsets expressing COL1A1 were enriched in dHGP, while αSMAlow_single cells were present at higher densities in non‐dHGP. Interestingly, Calprotectin+ cells confer better prognoses in non‐dHGP, identifying a subgroup of good outcome patients that unexpectedly also show an enrichment in other myeloid cells. In summary, our results illustrate different TME landscapes with respect to HGPs. dHGP presents a higher degree of immunocompetence, higher amounts of Collagen 1 as well as lesser presence of myeloid cell populations, features that might be influencing on the better prognosis of encapsulated metastases.
Synthesis, Characterization, and Measurement of New 1144‐Type Iron‐Based Superconductors: A Systematic Review
Authors: Mebratie Gedefaw , Negussie Tamiru , Kahsay Gebregziabher 
Published: November 2024

ABSTRACTThe newly discovered 1144‐type iron‐based superconductors (FeBSCs) are hybrids of the same two 122‐type structures. The novel 1144‐type FeBSCs were synthesized with a superconducting transition temperature ranging from 31 to 37 K. This study systematically investigates the current findings and future possibilities of EuRbFe4As4, EuCsFe4As4, CaRbFe4As4, and CaKFe4As4 FeBSCs since they have high upper critical magnetic field, high critical current density and low anisotropy, strong vortex pinning properties. The current review article gives a brief explanation on the crystal structure, electronic structure, band gap, magnetic properties, superconductivity, pairing mechanism, synthesis methods, characterization, and measuring mechanisms of the selected novel 1144‐type FeBSCs.
Centralized Investigator Review of Radiological and Functional Imaging Reports in Real‐World Oncology Studies: The SACHA‐France Experience
Authors: Berlanga Pablo , Aerts Isabelle , Corradini Nadège , Ndounga‐Diakou Lee Aymar , Entz‐Werle Natacha , Ducassou Stéphane , André Nicolas , Sevrin François , Chastagner Pascal , Puiseux Chloe , Cleirec Morgane , Plantaz Dominique , De Carli Emilie , Gambart Marion , Khanfar Camille , Thouvenin Sandrine , Petit Arnaud , Klein Sébastien , Briandet Claire , Millot Frédéric , Pluchart Claire , Reguerre Yves , Schneider Pascale , Serre Jill , Halfon‐Domenech Carine , Carausu Liana , Piguet Christophe , Saumet Laure , Benadiba Joy , Abbou Samuel , Laghouati Salim , Geoerger Birgit , Vassal Gilles 
Published: November 2024

ABSTRACTSACHA‐France (NCT04477681) is a prospective real‐world study that collects clinical safety and efficacy data of novel anticancer therapies prescribed off‐label or on compassionate use to patients <25 years. From March 2020 until February 2024, 640 patients with solid tumors or lymphomas were included, with 176 (28%) reported objective tumor responses. Centralized medical monitoring of local radiological/functional imaging reports by the SACHA coordinating investigator led to response modification in 45 out of 176 cases (26%), highlighting the relevance of the medical review of study data. We suggest this pragmatic approach for improving clinical trial data when centralized radiological review is not performed.
Potential for Recycled Silicon Solar Cells as Feedstock for New Ingot Growth
Authors: Geerligs L. J. , Kuypers Ando D. , Theelen Mirjam J. 
Published: November 2024

ABSTRACTThis paper investigates, by modeling, the potential for high‐value recycling of silicon wafers recovered from end‐of‐life PV modules. Technology for PV module recycling is making steady progress, both at recycling companies and R&D institutes, and it is possible that as a result, soon a stream of wafers or wafer fragments recovered from waste modules will become commercially available. Recycling the silicon for manufacturing of new PV modules is an opportunity both for reduction of cost and reduction of environmental footprint of PV. In this paper, we analyze possibilities for recycling of wafer fragments as feedstock for new silicon ingot growth. This could save up to about 0.16 kWh/Wp energy for production of the new PV system. Compared with lower value applications of the recovered silicon, the potential value and energy savings when used as feedstock for ingot growth are considerably higher. This paper presents the possibilities and challenges for recycling wafer fragments from the point of view of dopant type and resistivity control, and mitigation of the impact of recombination activity from possible increased impurity levels or related to boron. Because in current PV production a rapid transition to n‐type wafer doping is taking place, the paper also considers the question what can be done with p‐type doped recycled wafer material. We illustrate how application for perovskite–silicon tandem cells helps to mitigate possible performance loss from metallic impurities or boron. The application in tandem cells is perhaps the only realistic approach to make economically worthwhile use of recycled B‐doped silicon as feedstock for silicon ingot growth.
Impact of Self‐Regulated Learning Programs in Primary Education: A Systematic Review
Authors: Olid‐Luque Marta , Ayllón‐Salas Patricia , Arco‐Tirado José L. , Fernández‐Martín Francisco D. 
Published: November 2024

ABSTRACTThe aims of this systematic review were to identify, describe, and synthesize the characteristics and effectiveness of self‐regulated learning training programs on primary education students' self‐regulated learning and academic achievement. The study implemented a systematic review protocol that encompassed both primary and complementary literature searches to ensure the comprehensive inclusion of unbiased studies. Subsequently, the results were analyzed by narrative content analysis. After the selection process, 10 studies were finally qualified for data extraction and review. The results revealed that the selected interventions had a statistically significant positive impact and effectiveness in fostering students' self‐regulated learning. Additionally, many of them seemed to be effective in terms of improving pupils' academic performance. Nevertheless, this systematic review emphasizes the necessity for additional studies employing robust evaluation research designs to enhance the quality of research in this domain.
Bee bread collected by honey bees (Apis mellifera) as a terrestrial pesticide biomarker to complement water studies
Authors: Stalder Samira , Fracheboud Marion , Stalder Ann‐Kathrin , Droz Benoît , Chiaia‐Hernández Aurea C. , Kast Christina 
Published: November 2024

AbstractBACKGROUNDPesticides in aquatic environments are frequently studied, yet those in terrestrial environments remain relatively unexplored. This study monitored bee bread collected from two apiaries located in a typical agricultural environment in Switzerland from March to August 2022 as a proxy for terrestrial pesticide inputs. The temporal appearance of the selected pesticides was compared to their profiles in the water of a small catchment within this area.RESULTSOverall, 62% (31 of 50) of the targeted pesticides were detected in bee bread, with occurrences in both apiaries largely overlapping (23 pesticides), demonstrating a similar agricultural landscape across the region. Furthermore, nine pesticides were detected in bee bread and water, two pesticides were detected only in bee bread, and two additional pesticides were detected only in water. Comparative temporal analysis revealed that pesticides with moderate‐to‐high movement potential [Groundwater ubiquity score (GUS) ≥ 2.19] appeared simultaneously in bee bread and water (azoxystrobin, boscalid, flufenacet and terbuthylazine). However, pesticides with low movement potential (GUS ≤ 1.86) showed different profiles in both matrices (cyprodinil, prosulfocarb, tebuconazole and thiacloprid), indicating the difficulty of predicting their fate, given that they adhere to soil particles and cannot be covered by current water monitoring programmes.CONCLUSIONOur findings present bee bread as a viable biomarker for monitoring pesticides by complementing the conventional water monitoring, and permitting a more comprehensive assessment of the exposure of terrestrial organisms to pesticides. Bee bread allows immediate recording of the applied pesticides and promptly reflects the seasonal variation in pesticide use. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Improving Survey Inference Using Administrative Records Without Releasing Individual‐Level Continuous Data
Authors: Williams Sharifa Z. , Zou Jungang , Liu Yutao , Si Yajuan , Galea Sandro , Chen Qixuan 
Published: November 2024

ABSTRACTProbability surveys are challenged by increasing nonresponse rates, resulting in biased statistical inference. Auxiliary information about populations can be used to reduce bias in estimation. Often continuous auxiliary variables in administrative records are first discretized before releasing to the public to avoid confidentiality breaches. This may weaken the utility of the administrative records in improving survey estimates, particularly when there is a strong relationship between continuous auxiliary information and the survey outcome. In this paper, we propose a two‐step strategy, where the confidential continuous auxiliary data in the population are first utilized to estimate the response propensity score of the survey sample by statistical agencies, which is then included in a modified population data for data users. In the second step, data users who do not have access to confidential continuous auxiliary data conduct predictive survey inference by including discretized continuous variables and the propensity score as predictors using splines in a Bayesian model. We show by simulation that the proposed method performs well, yielding more efficient estimates of population means with 95% credible intervals providing better coverage than alternative approaches. We illustrate the proposed method using the Ohio Army National Guard Mental Health Initiative (OHARNG‐MHI). The methods developed in this work are readily available in the R package AuxSurvey.
Se‐Doped CoS2@MoS2 Heterostructures on Multiwalled Carbon Nanotubes as Efficient Bifunctional Electrocatalysts for Alkaline Overall Water Splitting
Authors: Jiang Yuwei , An Xuguang , Zhang Yu , Wang Feng , Abdukayum Abdukader , Kong Qingquan , Gao Sanshuang , Hu Guangzhi 
Published: November 2024

AbstractThe use of efficient and affordable non‐precious metal catalysts for hydrogen and oxygen evolution reactions is vital for replacing and widely implementing new energy sources. Nevertheless, improving the catalytic performance of these non‐precious‐metal bifunctional electrocatalysts continues to be a major challenge. In this article, an optimized Se‐incorporated bulk CoS2@MoS2 heterostructure grown on the surface of carbon nanotubes is reported. The resulting Se‐CoS2@MoS2/CNTs exhibit robust bifunctional electrocatalytic performance, with low overpotentials of 85 and 240 mV @ 10 mA·cm−2 for HER and OER, respectively. The materials exhibit superior long‐term stability of over 145 h, surpassing most electrocatalysts of similar type. This enhanced performance is attributed to the synergistic effect at the interface between the MoS2 and CoS2 phases, abundant active sites, and high active surface area, which collectively improves the electron‐transfer efficiency during the reaction process. Furthermore, the incorporation of the amorphous state of Se into the heterostructure yields a change in the crystallinity of the heterostructure in the electronic structure, which optimizes the adsorption and activation energy barriers of the catalytic intermediate. This study thus presents a promising approach to regulating anion doping in bifunctional electrocatalysts.
Federated Learning‐Based Mobile Traffic Prediction in Satellite‐Terrestrial Integrated Networks
Authors: Jiang Weiwei , Mu Jianbin , Han Haoyu , Zhang Yang , Huang Sai 
Published: November 2024

ABSTRACTIntroductionWith the development and integration of satellite and terrestrial networks, mobile traffic prediction has become more important than before, which is the basis for service provision and resource scheduling when supporting various vertical applications. However, existing traffic prediction methods, especially deep learning‐based methods, require massive data for model training. Due to data privacy concerns, mobile traffic data are not easily shared among different parties, making it difficult to obtain a precise prediction model.MethodsTo mitigate the data leakage risk, a federated learning framework is proposed in this study for mobile traffic prediction in satellite‐terrestrial integrated networks to achieve a tradeoff between data privacy and prediction accuracy. In the proposed framework, local models are trained in base stations on the ground, and a global model is aggregated in the satellite edge server in space.ResultsA deep learning‐based prediction model with an adaptive graph convolutional network (AGCN) and long short‐term memory (LSTM) modules is proposed and validated in numerical experiments, which achieves the lowest prediction error with a real‐world traffic dataset when compared with other graph neural network (GNN) variants in the federated learning setting.ConclusionNumerical experiments with a real‐world mobile traffic dataset demonstrate the effectiveness of the proposed approach, which outperforms other GNN variants with lower prediction errors.
N‐Heterocyclic Carbene Catalyzed Reactions Involving Acetylenic Breslow and/or Acylazolium as Key Intermediates
Authors: He Yujie , Chen Jintao , Jiang Yu , Fang Xiaoyu , Liu Junyang , Yan Jia‐Lei 
Published: November 2024

AbstractN‐heterocyclic carbene (NHC) organocatalysis has been developed as a powerful tool in modern synthetic chemistry. NHC catalytic activation of ynals and alkynoic acid derivatives provided versatile reactions that involve acetylenic Breslow and/or acylazolium as key intermediates, and diverse transformations have been established for access to molecules with unique skeletons in efficient fashions. Herein we summarize the recent achievements in NHC‐catalyzed reactions involving acetylenic Breslow and/or acylazolium intermediates. Different reactions belonging to three catalytic modes, including (1) conjugate additions to acetylenic Breslow derived α,β‐unsaturated acylazolium intermediates, (2) β‐umpolung of ynals via acetylenic Breslow intermediates, and (3) conjugate additions to acetylenic acylazolium intermediates, are emphasized with examples and plausible mechanisms cited to guide a better understanding.
Radiographic and tomographic findings of excretory urography of avian kidneys after induced nephropathy in broiler chicken as a model
Authors: Zangisheh Mahsa , Masoudifard Majid , Madani Seyed Ahmad , Vajhi Alireza , hasannejhad Hamideh , Ghojoghi Ameneh 
Published: November 2024

AbstractBackgroundAlthough kidney diseases have a high prevalence, initial recognition and diagnosis of renal disease are complicated in avian medicine.ObjectiveThe aim of this study is to assess the intraosseous excretory urography (IOEU) in order to introduce a new method for evaluation of kidney's function in broilers as a primary model of birds.MethodsA total of 10 male broiler chickens at the age of 20 days were included and evaluated with plain and serial post‐contrast radiography and computed tomography (CT) scan to check the time and concentration of the contrast media (CM) passage from the kidney. In the next step, after the nephropathy induction with gentamicin, plain and serial post‐contrast radiography and CT scan were repeated. After the necropsy, kidney samples were sent for histopathology evaluation, and statistical analysis of data obtained from image analysis was conducted.ResultsAfter nephropathy induction, all of the chickens exhibited increase in kidney size and in histopathological evaluation, all the samples (30 of 30) showed severe tubular necrosis and mild glomerulopathy. In the IOEU, the average time to create the maximum concentration of CM, the average time to decrease the CM concentration from the kidney and the time of the complete clearance of CM indicated a significant incensement after nephropathy compared to the time before it.ConclusionIntraosseous excretory urography (IOEU) is a safe contrast imaging modality and can be useful in the assessment of the urinary system in chickens to check the changes in kidney size and function.
The Use of Intra‐Operative Endoscopy in Dogs and Cats for the Removal of Gastrointestinal Foreign Bodies: Five Cases (2014–2015)
Authors: Israeli Inbar 
Published: November 2024

ABSTRACTObjectivesWe report the use of intra‐operative endoscopy, termed here ‘surgically‐assisted endoscopy’. The procedure spares a gastrotomy, therefore, shortening anaesthetic time, minimising potential complications and resulting in a quicker and less painful recovery.MethodsFour dogs and one cat requiring surgical celiotomy for various conditions were treated. In all animals, a gastrointestinal foreign body (FB) was located at surgery. During the surgery, with the patient still in dorsal recumbency and the abdomen still open, in lieu of gastrotomy, the animals had their FBs removed via endoscopy, sparing a gastrotomy procedure and its potential complications.ResultsIn all five cases, a gastrotomy was avoided and the FBs were successfully extracted using the endoscope. Only one minor complication was seen intra‐operatively and none at short‐term follow‐up.Clinical SignificanceAlthough prognosis after gastrotomy is considered excellent, potential complications still exist and include haemorrhage, intra‐operative spillage, peritonitis and post‐operative dehiscence. Alternatively, endoscopy negates many of those possible complications and shortens anaesthesia time. In many cases of gastric FBs, or where intestinal FBs can be safely manipulated into the stomach, surgically assisted endoscopy could be considered a viable and potentially preferred option to gastrotomy.