bluuebunny/crossref_metadata_2025_split huggingface dataset:
Truth, consequences, and the Evil-god challenge: a response to Anastasia Scrutton
Authors: LANCASTER-THOMAS ASHA 
Published: October 2018

AbstractIn her 2016 article in Religious Studies, Anastasia Scrutton attempts to undermine Stephen Law's Evil-god challenge by arguing that belief in a good god is more justified than belief in an evil god, despite the alethic similarity of the two hypotheses. Drawing on the epistemological theory of pragmatic encroachment, Scrutton claims that is it more reasonable to believe in a benevolent deity than a malevolent one because belief in the latter (i) is detrimental to one's well-being and (ii) has worse moral consequences, whereas belief in the former (i) is good for one's well-being and (ii) has better moral consequences. In this article, I critically respond to Scrutton's argument by proposing that even if belief in a good god results in better consequences than belief in an evil god does, pragmatic encroachment does not undermine the Evil-god challenge. I further argue that pragmatic encroachment potentially undermines itself in this instance.
Would Aristotle Have Seen the Wrongness of Slavery If He Had Undergone a Course of Moral Enhancement?
Authors: Pleasants Nigel 
Published: October 2018

AbstractI agree with those proponents of bio-medical moral enhancement who claim that we face large-scale global moral problems which are currently un-recognised or un-acted upon. But I argue that the proposed bio-medical means for tackling them is misconceived. I show that both bio-medical and “traditional” conceptions of moral enhancement share a misleading picture of the relation between the moral psychology of individuals and the socially structured moral problems with which they are faced. The argument unfolds in three stages. First I reflect on prominent historical cases of large-scale progressive moral change to assess the role of the agents’ moral psychology in bringing that about and sustaining it. Second, I identify some current cases of people recognising one or more of (what I call) the “new moral problems” that we face but not acting in accordance with that recognition. Third, I adumbrate an alternative stance to the idea of both traditional and bio-medical moral enhancement.
Moral Enhancement and the Human Condition
Authors: Skidelsky Edward 
Published: October 2018

AbstractI argue that the project of moral enhancement is incipiently contradictory. All our judgements of human excellence and deficiency rest on what I call the human “form of life”, meaning that a radical transformation of this form of life, such as is envisioned by advocates of moral enhancement, would undermine the basis of those judgements. It follows that the project of moral enhancement is self-defeating: its fulfilment would spell the abolition of the very conditions that allow us to describe it as an “enhancement”.
Moral Enhancement and Climate Change: Might it Work?
Authors: Kulawska Aleksandra , Hauskeller Michael 
Published: October 2018

AbstractClimate change is one of the most urgent global problems that we face today. The causes are well understood and many solutions have been proposed; however, so far none have been successful. Ingmar Persson and Julian Savulescu have argued that this is because our moral psychology is ill-equipped to deal with global problems such as this. They propose that in order to successfully mitigate climate change we should morally enhance ourselves. In this chapter we look at their proposal to see whether moral enhancement is indeed a viable solution to the climate crisis, and conclude that due to various theoretical and practical problems it most likely is not.
A novel technique for iatrogenic pseudoaneurysm obliteration with ultrasound-guided thrombin foam injection
Authors: Lewandowski Paweł , Baran Jakub , Maciejewski Paweł , Budaj Andrzej 
Published: October 2018

Abstract. Background: Iatrogenic pseudoaneurysms (IPA) are treated with ultrasound-guided thrombin injections (UGTI). We describe a novel technique for IPA repair that applies UGTI with thrombin foam (UGTFI). Methods and results: Successful obliteration of 6 IPAs (IPA without a neck, n = 5; with a neck, n = 1) in 6 patients (2 males, aged 68 ± 1 years, 4 females, aged 59 ± 11 years) was performed by using UGTFI. The dose of administered thrombin was 25–75 IU. No microembolization phenomenon and no serious clinical complications were observed. Conclusions: Treatment of IPA with UGTFI may reduce the embolization rate, risk of IPA cavity thrombin leakage, required drug dose. Use of the thrombin foam could be the next step in the development of the UGTI, particularly in the treatment of IPA without a neck. Keywords: Iatrogenic pseudoaneurysms, thrombin, ultrasound-guided thrombin injection, UGTI
Spatial Distribution of Fine‐Structured and Unstructured EMIC Waves Observed by the Arase Satellite
Authors: Matsuda S. , Kasahara Y. , Miyoshi Y. , Nomura R. , Shoji M. , Matsuoka A. , Kasaba Y. , Kurita S. , Teramoto M. , Ishisaka K. 
Published: October 2018

AbstractWe surveyed 378 electromagnetic ion cyclotron (EMIC) wave events using Arase during the first 12 months. We discriminated the observed EMIC waves into two types (fine‐structured EMIC waves and unstructured EMIC waves), according to whether or not they exhibited clear periodic amplitude modulations. We found a clear afternoon peak in the occurrence probability of unstructured EMIC waves in the region of L = 5–9. Fine‐structured EMIC waves were mainly distributed in the off‐equatorial region, and their occurrence probability was clearly high around the noon sector. Such noon sector EMIC wave peaks had not been found in the THEMIS, AMPTE, or Cluster measurements, due to their limited L shell coverages. The Van Allen probes, too, were not able to measure the major region of fine‐structured EMIC waves because of their limited latitudinal coverage. Our unique statistical results demonstrate the importance of discriminating the wave structures as well as of performing observations over a wide range of latitudes.
Rapid Oligocene to Early Miocene Extension Along the Grant Range Detachment System, Nevada, USA: Insights From Multipart Cooling Histories of Footwall Rocks
Authors: Long Sean P. , Heizler Matthew T. , Thomson Stuart N. , Reiners Peter W. , Fryxell Joan E. 
Published: October 2018

AbstractIn Nevada and Utah, the Cordilleran orogen underwent a protracted Cenozoic transition to an extensional setting. However, the geodynamic processes that controlled this transition are poorly understood, in part because the space‐time patterns of extension are not known in many areas. Localities of pre‐Neogene extension have the potential to elucidate the dynamics of the Cordilleran crust during the final stages of subduction. Here we present data that constrain the timing of extension in the Grant Range in eastern Nevada, which was deformed by a low‐angle normal fault system. We present temperature‐time histories of eight granite samples exhumed by this fault system, constrained by muscovite 40Ar/39Ar multi‐diffusion domain modeling and fission track and (U‐Th)/He ages from zircon and apatite. These data demonstrate rapid cooling (20–35 °C/Myr) from 350–425 to 25–50 °C between 28–31 and 15–19 Ma. The fault system accommodated ~24 km of extension (~115%), and exhumed the granite samples from 7–9 km depths to the near‐surface. Rapid Oligocene‐early Miocene cooling is interpreted to date the duration of motion on the fault system, and defines an extension rate of 1.5–2.6 km/Myr. This was one of the most significant fault systems active during an episode of spatially distributed late Eocene‐Oligocene extension, which overlaps temporally with volcanism generated by slab rollback. Reduced interplate coupling that accompanied slab rollback is interpreted as the primary driver of extension of the Cordilleran plateau during the final stages of subduction. This supports a scenario of orogenic collapse that proceeded in distinct episodes that were initiated by external geodynamic events.
Ultrafast cryptography with indefinitely switchable optical nanoantennas
Authors: Ma Pujuan , Gao Lei , Ginzburg Pavel , Noskov Roman E. 
Published: October 2018

AbstractBistability is widely exploited to demonstrate all-optical signal processing and light-based computing. The standard paradigm of switching between two steady states corresponding to “0” and “1” bits is based on the rule that a transition occurs when the signal pulse intensity overcomes the bistability threshold, and otherwise, the system remains in the initial state. Here, we break with this concept by revealing the phenomenon of indefinite switching in which the eventual steady state of a resonant bistable system is transformed into a nontrivial function of signal pulse parameters for moderately intense signal pulses. The essential nonlinearity of the indefinite switching allows realization of well-protected cryptographic algorithms with a single bistable element in contrast to software-assisted cryptographic protocols that require thousands of logic gates. As a proof of concept, we demonstrate stream deciphering of the word “enigma” by means of an indefinitely switchable optical nanoantenna. An extremely high bitrate ranging from ~0.1 to 1 terabits per second and a small size make such systems promising as basic elements for all-optical cryptographic architectures.
Atmospheric sulfur is recycled to the crystalline continental crust during supercontinent formation
Authors: LaFlamme Crystal , Fiorentini Marco L. , Lindsay Mark D. , Bui Thi Hao 
Published: October 2018

AbstractThe sulfur cycle across the lithosphere and the role of this volatile element in the metasomatism of the mantle at ancient cratonic boundaries are poorly constrained. We address these knowledge gaps by tracking the journey of sulfur in the assembly of a Proterozoic supercontinent using mass independent isotope fractionation (MIF-S) as an indelible tracer. MIF-S is a signature that was imparted to supracrustal sulfur reservoirs before the ~2.4 Ga Great Oxidation Event. The spatial representation of multiple sulfur isotope data indicates that successive Proterozoic granitoid suites preserve Δ33S up to +0.8‰ in areas adjacent to Archean cratons. These results indicate that suturing of cratons began with devolatilisation of slab-derived sediments deep in the lithosphere. This process transferred atmospheric sulfur to a mantle source reservoir, which was tapped intermittently for over 300 million years of magmatism. Our work tracks pathways and storage of sulfur in the lithosphere at craton margins.
Group decision-making is optimal in adolescence
Authors: Haller Simone P. W. , Bang Dan , Bahrami Bahador , Lau Jennifer Y. F. 
Published: October 2018

AbstractGroup decision-making is required in early life in educational settings and central to a well-functioning society. However, there is little research on group decision-making in adolescence, despite the significant neuro-cognitive changes during this period. Researchers have studied adolescent decision-making in ‘static’ social contexts, such as risk-taking in the presence of peers, and largely deemed adolescent decision-making ‘sub-optimal’. It is not clear whether these findings generalise to more dynamic social contexts, such as the discussions required to reach a group decision. Here we test the optimality of group decision-making at different stages of adolescence. Pairs of male pre-to-early adolescents (8 to 13 years of age) and mid-to-late adolescents (14 to 17 years of age) together performed a low-level, perceptual decision-making task. Whenever their individual decisions differed, they were required to negotiate a joint decision. While there were developmental differences in individual performance, the joint performance of both adolescent groups was at adult levels (data obtained from a previous study). Both adolescent groups achieved a level of joint performance expected under optimal integration of their individual information into a joint decision. Young adolescents’ joint, but not individual, performance deteriorated over time. The results are consistent with recent findings attesting to the competencies, rather than the shortcomings, of adolescent social behaviour.
Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy
Authors: Latt Khun Zaw , Honda Kenjiro , Thiri Myo , Hitomi Yuki , Omae Yosuke , Sawai Hiromi , Kawai Yosuke , Teraguchi Shunsuke , Ueno Kazuko , Nagasaki Masao , Mabuchi Akihiko , Kaga Hajime , Komatsuda Atsushi , Tokunaga Katsushi , Noiri Eisei 
Published: October 2018

AbstractThe associations of single nucleotide polymorphisms (SNPs) in PLA2R1 and HLA-DQA1, as well as HLA-DRB1*15:01-DQB1*06:02 haplotype with idiopathic membranous nephropathy (IMN) is well known. However, the primary associations of these loci still need to be determined. We used Japanese-specific SNP genotyping array and imputation using 2,048 sequenced Japanese samples to fine-map PLA2R1 region in 98 patients and 413 controls. The most significant SNPs were replicated in a separate sample set of 130 patients and 288 controls. A two-SNP haplotype of intronic and missense SNPs showed the strongest association. The intronic SNP is strongly associated with PLA2R1 expression in the Genotype-Tissue Expression (GTEx) database, and the missense SNP is predicted to alter peptide binding with HLA-DRB1*15:01 by the Immune Epitope Database (IEDB). In HLA region, we performed relative predispositional effect (RPE) tests and identified additional risk alleles in both HLA-DRB1 and HLA-DQB1. We collapsed the risk alleles in each of HLA-DRB1 and HLA-DQB1 into single risk alleles. Reciprocal conditioning of these collapsed risk alleles showed more residual significance for HLA-DRB1 collapsed risk than HLA-DQB1 collapsed risk. These results indicate that changes in the expression levels of structurally different PLA2R protein confer risk for IMN in the presence of risk HLA-DRB1 alleles.
Assessment of Concurrent Chemoradiotherapy plus Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma: Cisplatin, Fluorouracil, and Docetaxel versus Gemcitabine and Cisplatin
Authors: Zeng Zhen , Yan Ruo-Nan , Tu Li , Wang Yu-Yi , Chen Pei-Ran , Luo Feng , Liu Lei 
Published: October 2018

AbstractInduction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the treatment outcomes and toxicities between two induction chemotherapy regimens, with both followed by concurrent chemoradiotherapy. The first strategy used docetaxel, cisplatin and fluorouracil for induction chemotherapy (TPF), and the second utilised gemcitabine and cisplatin (GP). A retrospective analysis was performed on eligible NPC patients attending our hospital between May 2009 and Dec 2014. A total of 113 patients were enrolled with 58 patients receiving TPF and 55 receiving GP induction chemotherapy. Ninety-four patients (83.2%) were alive after 36-months follow-up. The median overall survival (OS) and progression-free survival (PFS) time were 48.3 and 39.7 months, respectively. The 3-year OS for the TPF regimen was 87.9% and 87.4% with GP chemotherapy (P = 0.928). The 3-year PFS of the TPF treatment was 84.5%, while it was 83.5% for the GP group (P = 0.551). Univariate analysis showed that lymph node metastasis was a significant PFS prognostic factor, while N3 stage was an independent predictor of PFS and distant failure-free survival (DMFS) in multivariate analysis. There were no significant differences in adverse toxicities or treatment efficacy between the chemotherapy regimens in the treatment of locoregionally advanced NPC.
Projections of the future disappearance of the Quelccaya Ice Cap in the Central Andes
Authors: Yarleque Christian , Vuille Mathias , Hardy Douglas R. , Timm Oliver Elison , De la Cruz Jorge , Ramos Hugo , Rabatel Antoine 
Published: October 2018

AbstractWe analyze the future state of Quelccaya Ice Cap (QIC), the world’s largest tropical ice cap with a summit elevation of 5680 m a.s.l., which, in terms of its elevation range (~5300–5680 m a.s.l.), is representative of many low-elevation glacierized sites in the tropical Andes. CMIP5 model projections of air temperature (Ta) at QIC indicate a warming of about 2.4 °C and 5.4 °C (respectively) for RCP4.5 and RCP8.5 scenarios by the end of the 21stcentury, resulting in a pronounced increase in freezing level height (FLH). The impact of this warming on the QIC was quantified using equilibrium-line altitude (ELA) projections. The change in the ELA was quantified based on an empirical ELA–FLH relationship, and calibrated with observations of the highest annual snowline altitude (SLA) derived from LANDSAT data. Results show that from the mid-2050s onwards, the ELA will be located above the QIC summit in the RCP8.5 scenario. At that time, surface mass balance at QIC and most tropical glaciers at similar elevations will become increasingly negative, leading to their eventual complete disappearance. Our analysis further corroborates that elevation-dependent warming (EDW) contributes significantly to the enhanced warming over the QIC, and that EDW at Quelccaya depends on the rate of anthropogenic forcing.
Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals
Authors: Perisin Matthew A. , Sund Christian J. 
Published: October 2018

AbstractFood waste represents an underutilized resource for commodity chemical generation. Constituents of the human gut microbiota that are already adapted to a food waste stream could be repurposed for useful chemical production. Industrial fermentations utilizing these microbes maintain organisms in isolation; however, microbial consortia offer an attractive alternative to monocultures in that metabolic interactions may result in more efficient processes with higher yields. Here we computationally assess the ability of co-cultures vs. monocultures to anaerobically convert a Western diet to commodity chemicals. The combination of genome-scale metabolic models with flux-balance analysis predicts that every organism analyzed can benefit from interactions with another microbe, as evidenced by increased biomass fluxes in co-culture vs. monoculture. Furthermore, microbe combinations result in emergent or increased commodity chemical production including butanol, methane, formaldehyde, propionate, hydrogen gas, and urea. These overproducing co-cultures are enriched for mutualistic and commensal interactions. Using Clostridium beijerinckii co-cultures as representative examples, models predict cross-fed metabolites will simultaneously modify multiple internal pathways, evident by different internal metabolic network structures. Differences in degree and betweenness centrality of hub precursor metabolites were correlated to C. beijerinckii metabolic outputs, and thus demonstrate the potential of co-cultures to differentially direct metabolisms to useful products.
A double guidance mechanism, nitroaniline based microstructured optical fiber
Authors: Violakis Georgios , Pissadakis Stavros 
Published: October 2018

AbstractA new type of all-solid, photonic bandgap fiber exhibiting a wavelength dependent guidance mechanism and second harmonic generation capabilities is presented. A silica glass microstructured optical fiber was infiltrated with 2-methyl 4-nitroaniline for creating the composite material optical fiber. This optical fiber was characterized over a broad wavelength range, revealing that a transition from photonic bandgap guidance to modified total internal reflection propagation occurs from short to longer wavelengths, attributed to the dispersion characteristics of the low Abbe number nitroaniline. Annealing post-processing was used for tuning the morphology of the solidified nitroaniline inside the capillaries of the silica glass microstructured optical fiber which increased the extinction ratio of the transmission bandgaps. This composite material optical fiber also exhibits second harmonic generation capabilities under 1064 nm laser excitation, with conversion characteristics dependent upon the packing of the nitroaniline inside the optical fiber capillaries. As the pump and generated light fall into different guidance regimes of the optical fiber, such a device could be potentially used as an all optical gate or light conversion device.
Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
Authors: Xu Jin , Jia Yun-Fang , Tapadar Subhasish , Weaver Jessica D. , Raji Idris O. , Pithadia Deeti J. , Javeed Naureen , García Andrés J. , Choi Doo-Sup , Matveyenko Aleksey V. , Oyelere Adegboyega K. , Shin Chong Hyun 
Published: October 2018

Abstractβ-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε), as enhancers of β-cell regeneration. The most potent β-cell regeneration enhancer was a cinnamic acid derivative (E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid (PIAA), which, acting through the cAMP-dependent protein kinase A (PKA), stimulated β-cell-specific proliferation by increasing cyclic AMP (cAMP) levels and mechanistic target of rapamycin (mTOR) activity. A combination of PIAA and cilostamide, an inhibitor of β-cell-enriched cAMP hydrolyzing enzyme phosphodiesterase (PDE) 3, enhanced β-cell proliferation, whereas overexpression of PDE3 blunted the mitogenic effect of PIAA in zebrafish. PIAA augmented proliferation of INS-1β-cells and β-cells in mammalian islets including human islets with elevation in cAMP levels and insulin secretion. PIAA improved glycemic control in streptozotocin (STZ)-induced diabetic mice with increases in β-cell proliferation, β-cell area, and insulin content in the pancreas. Collectively, these data reveal an evolutionarily conserved and critical role of TBK1/IKKε suppression in expanding functional β-cell mass.
Pattern of reading eye movements during monovision contact lens wear in presbyopes
Authors: Zeri Fabrizio , Naroo Shehzad A. , Zoccolotti Pierluigi , De Luca Maria 
Published: October 2018

AbstractMonovision can be used as a method to correct presbyopia with contact lenses (CL) but its effect on reading behavior is still poorly understood. In this study eye movements (EM) were recorded in fifteen presbyopic participants, naïve to monovision, whilst they read arrays of words, non-words, and text passages to assess whether monovision affected their reading. Three conditions were compared, using daily disposable CLs: baseline (near correction in both eyes), conventional monovision (distance correction in the dominant eye, near correction in the non-dominant eye), and crossed monovision (the reversal of conventional monovision). Behavioral measures (reading speed and accuracy) and EM parameters (single fixation duration, number of fixations, dwell time per item, percentage of regressions, and percentage of skipped items) were analyzed. When reading passages, no differences in behavioral and EM measures were seen in any comparison of the three conditions. The number of fixations and dwell time significantly increased for both monovision and crossed monovision with respect to baseline only with word and non-word arrays. It appears that monovision did not appreciably alter visual processing when reading meaningful texts but some limited stress of the EM pattern was observed only with arrays of unrelated or meaningless items under monovision, which require the reader to have more in-depth controlled visual processing.