bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doping Si/O to enhance interfacial occupancy of demulsifiers for low‐carbon breaking of water‐in‐heavy oil emulsions
Authors: Tian Ying , He Changqing , Zhang Xincheng , He Lin , Xu Zhenghe , Sui Hong , Li Xingang 
Published: November 2024

AbstractSeparating water‐in‐heavy oil (W/HO) emulsions at low (room) temperature is challenging when exploiting heavy oil. We propose an adaptable strategy for constructing Si/O‐doped demulsifiers. A nonionic demulsifier (APBMP) has been synthesized based on polysiloxane modified by allyl polyether and butyl acrylate. APBMP achieves 95.97% dehydration within 5 min for W/HO emulsions at 288.15 K and complete dehydration in 15 min at 323.15 K. Mechanistic studies found that doping Si/O into the demulsifier molecules increases the number of hydrogen bond sites, which enables the demulsifiers to quickly disperse natural stabilizers (e.g., asphaltenes) and replace them at the oil–water interfacial film. The demulsifiers prefer to occupy the interfacial sites rather than dissolve into the bulk oil or water phases. Driven by hydrogen‐bond‐dominated noncovalent interactions, the oil–water interfacial film is softened, reconstructed, and broken. These findings provide insights into developing novel materials for oil–water separations in a low‐carbon way.
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)
Authors: Mormino Elizabeth C. , Biber Sarah A. , Rahman‐Filipiak Annalise , Arfanakis Konstantinos , Clark Lindsay , Dage Jeffrey L. , Detre John A. , Dickerson Bradford C. , Donohue Michael C. , Kecskemeti Steven , Hohman Timothy J. , Jagust William J. , Keene Dirk C. , Kukull Walter , Levendovszky Swati R. , Rosen Howie , Thompson Paul M. , Villemagne Victor L. , Wolk David A. , Okonkwo Ozioma C. , Rabinvovici Gil D. , Rivera‐Mindt Monica , Foroud Tatiana , Johnson Sterling C. 
Published: November 2024

AbstractThe presence of multiple pathologies is the largest predictor of dementia. A major gap in the field is the in vivo detection of mixed pathologies and their antecedents. The Alzheimer's Disease Research Centers (ADRCs) are uniquely positioned to address this gap. The ADRCs longitudinally follow ≈ 17,000 participants, ranging from cognitively unimpaired to dementia, arising from Alzheimer's disease (AD) and related dementias (ADRD; e.g., AD, Lewy body disorders, vascular). Motivated by the Alzheimer's Disease Neuroimaging Initiative's (ADNI) impact, the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) was formed. Leveraging existing ADRC infrastructure, CLARiTI will integrate standardized imaging and plasma collection to characterize mixed pathologies and use community‐engaged research methods to ensure that ≥ 25% of the sample is from underrepresented populations (e.g., ethnoculturally minoritized, low education). The resulting ADRD profiles, within a more diverse sample, will provide key resources for ADRCs and an unprecedented, more generalizable publicly available imaging‐plasma dataset.Highlights
In vivo detection of mixed pathologies is critical for Alzheimer's disease and related dementias research.
The Alzheimer's Disease Research Centers (ADRCs) are uniquely positioned to address gaps related to mixed pathologies.
The ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) will enhance this national program by adding standardized imaging and plasma collection to existing ADRC infrastructure.
This effort will provide key resources for ADRCs and an unprecedented publicly available imaging–plasma–neuropath dataset.
Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease
Authors: Koops Elouise A. , Dutta Joyita , Hanseeuw Bernard J. , Becker J. Alex , Van Egroo Maxime , Prokopiou Prokopis C. , Price Julie C. , Arnold Steven E. , Sperling Reisa A. , Johnson Keith A. , Jacobs Heidi I. L. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

AbstractINTRODUCTIONAlterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)‐pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.METHODSWe examined associations of [18F]‐fluorodeoxyglucose positron emission tomography (FDG‐PET) ‐derived LC metabolism with clinical diagnostic status, cerebrospinal fluid (CSF) ‐based AD biomarkers of AD pathology, and cognitive decline in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 604).RESULTSFDG‐PET‐derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline in preclinical stages, particularly in those with low CSF Aβ42, but not in AD patients with cognitive impairment.DISCUSSIONHigher locus coeruleus [18F]‐FDG‐PET‐derived signal in the early preclinical stages of AD can confer cognitive resilience and may reflect increased metabolic activity, whereas later stages are characterized by lower LC FDG‐PET‐derived signal, possibly due to neurodegeneration.Highlights
LC FDG‐PET signal is lower in Alzheimer's disease (AD) patients.
LC FDG‐PET signal is higher in the preclinical stage of AD.
We observed less memory decline in those with higher LC FDG‐PET signal.
Higher LC FDG‐PET signal conferred cognitive resilience in preclinical AD.
An Yb(OTf)₃‐Mediated Indirect Activation Strategy for the Stereoselective Synthesis of α‐Sialosides from 2‐Fluorosialyl Donors
Authors: Ruan Bo‐Chang , Li Cheng‐Hsu , Chang Huai‐En , Li Pei‐Jhen 
Published: November 2024

AbstractMost of chemical sialylation reactions are conducted at extremely low temperatures to achieve the formation of challenging sialic acid linkages with high stereoselectivities. Performing chemical sialylation at room temperature independent of enzymatic methods represents an effective approach, particularly significant in biological and biochemical research. Our study aims to develop a convenient method of providing α‐sialyl glycosides. Herein, we carry out sialyation using Yb(OTf)3 as an activating promoter at room temperature in tetrahydrofurane and obtain excellent stereoselectivities when reacting the N‐acetyl‐5‐N,4‐O‐carbonyl‐2‐fluorosialyl donor with galacto‐ or glucopyranosides. The advantages of this method include an over eight‐month shelf life of the sialyl donors and minimal formation of the hydrolyzed or eliminated side‐products. Sialylation of the C3 hydroxyl group in galactosides affords exclusive α‐selectivities, and a one‐pot synthesis of trisaccharide is accomplished by application of this method. Finally, we anticipate that this sialylation strategy can compensate for the limitations of the current enzymatic synthesis of complex glycans.
Dual (oxy)hydroxide Cocatalyst Synergistically Boosts Solar Water Splitting of BiVO4 Photoanode
Authors: Su Youyi , Du Yian , Yan Ruyu , Wang Haohua , Zhang Ming , Pang Xiangui , Peng Pai , Yang Pingping , Lu Xinxin , Xie Jiale 
Published: November 2024

AbstractBismuth oxide (BiVO4) is considered one of the most promising semiconductors for photoelectrochemical (PEC) water splitting due to its highly theoretical photocurrent of 7.5 mA cm−2. However, its sluggish kinetics and severe photocorrosion still hinder the real application of a large‐area BiVO4 photoanode. Herein, a room‐temperature immersion method has been used to fabricate a dual cocatalyst‐coated BiVO4 film, namely the BiVO4/FeOOH/Co(OH)2 photoanode. This composite photoanode delivers a photocurrent density of 2.56 mA cm−2, which is 2.7 times that of pure BiVO4. After a long‐term testing of 10 h, its retention rate of photocurrent reaches 71.63 %, which is 4.6 times that of BiVO4. The kinetic studies illustrate that dual cocatalyst can significantly lower the charge transfer resistance, improve the charge injection efficiency, and reduce the Tafel slope. Specifically, FeOOH plays a role in transporting photogenerated holes, while Co(OH)2 facilitates water oxidation reactions. In addition, the dual cocatalyst coating can slow down vanadium ion dissolution and improve PEC stability. This immersion method can easily be applied to large‐area photoelectrodes.
Prescribing Agreement Improves Judgments and Decisions
Authors: Voinov Pavel V. , Knoblich Günther 
Published: November 2024

ABSTRACTWe investigated whether prescribing agreement improves the quality of judgments and decisions. Participants were first asked to provide judgments or decisions individually. Then, they either revised their initial judgments and decisions based on a partners' response, or they provided a joint judgment agreed upon with their partner. In the latter condition, we allowed for a minimal communication protocol restricted to acceptance and rejection responses to each other's proposals. In the Agreement condition, participants improved both in a cognitive (Experiment 1a) and a perceptual decision task (Experiment 1b). The cognitive task agreement allowed participants to improve above the level of accuracy achieved with revision. Surprisingly, the prescribing agreement improved the quality of the initial independent decisions. In a judgment task (Experiment 2), the prescribing agreement led to more accurate judgments because partners weighed each other's judgments more equally than in the Revision condition where they gave higher weight to their own judgments. We conclude that prescribing agreement reduces egocentric discounting bias and motivates individuals to be more accurate. These results not only demonstrate that collective benefits in judgment and decision making can be accrued without verbal communication but also suggest potential limitations of this approach.
Fluorescence Turn‐Off‐On Sensing Strategy for the Detection of Pb2+ and Metalaxyl Fungicide Using Yellow Fluorescent Carbon Dots From Cordia dichotoma Fruits
Authors: Vadia Foziya Yusuf , Malek Naved I. , Park Tae Jung , Kailasa Suresh Kumar 
Published: November 2024

ABSTRACTIn this work, a facile and rapid fluorescence turn‐off‐on sensing method was developed for the detection of Pb2+ and metalaxyl fungicide in environmental samples using yellow carbon dots (CDs) from Cordia dichotoma fruits. The prepared C. dichotoma‐CDs showed the emission band (𝜆Em) at 535 nm under 448 nm of excitation wavelength. The fluorescence intensity of C. dichotoma‐CDs quenches by Pb2+ ion and then restores by metalaxyl fungicide, favoring to develop a fluorescence turn‐off‐on sensing strategy. The intensity ratios (I0/I and I/I0) are linear against Pb2+ (0.01–50 μM) and metalaxyl fungicide (0.025–10 μM) concentrations, offering the detection limits of 0.0054 and 0.0087 μM for Pb2+ and metalaxyl fungicide, respectively. Additionally, the potential application of C. dichotoma‐CD‐based fluorescence turn‐off‐on sensing approach was effectively demonstrated for Pb2+ and metalaxyl fungicide assays in real samples, which confirms that C. dichotoma‐CDs act as “turn‐off‐on” fluorescent probe for assaying of Pb2+ and metalaxyl fungicide, respectively.
Sequence and Configuration of a Novel Bispecific Antibody Format Impacts Its Production Using Chinese Hamster Ovary (CHO) Cells
Authors: Hussain Hirra , Ozanne Angelica M. S. , Patel Tulshi , Vito Davide , Ellis Mark , Hinchliffe Matthew , Humphreys David P. , Stephens Paul E. , Sweeney Bernie , White James , Dickson Alan J. , Smales C. Mark 
Published: November 2024

ABSTRACTThere are a number of new format antibody‐inspired molecules with multiple antigen binding capabilities in development and clinical evaluation. Here, we describe the impact of the sequence and configuration of a unique bispecific antibody format (termed BYbe) using a panel of four BYbe's and the three IgG1s from which they were derived on their production in a Chinese hamster ovary (CHO) cell expression system. Following transfection and selection, one bispecific antibody format yielded fewer mini‐pools in comparison to the other bispecific cell pools. When the top 12 expressing stable mini‐pools of all BYbe configurations and sequences were evaluated, both the dsscFv sequence and antibody chain configuration or placement directly impacted productivity. The cell‐specific productivity (qP, pg/cell/day) was lower in all BYbe cell pools compared to the IgG1 cell lines. However, when the actual molecules/cell/day produced were considered, three of the four bispecific cell pools outproduced the parental IgG1 cell pools. While gene copy number did not correlate to productivity, mRNA analysis showed that for specific BYbe formats there was a strong correlation with productivity. In summary, we describe how bispecific antibody format configuration impacts the cell line construction process and yield of product from CHO cells.
Development of a Microphysiological System to Model Human Cancer Metastasis From the Colon to the Liver
Authors: Miller Paula G. , Huang Emina , Fisher Robert , Shuler Michael L. 
Published: November 2024

ABSTRACTWe describe a novel device to mimic the metastasis of cancer cells from the colon into the liver in a human model. The colon mimic is connected to the liver model by a gravity‐driven recirculating unidirectional flow of a blood surrogate and can mimic the five steps of the metastatic cascade: invasion in the colon, intravasation into the bloodstream, systemic transportation, extravasation into the liver, and colonization in the liver. The colon mimic uses established normal colon epithelial organoid cells (NL) and human umbilical vein endothelial cells (HUVEC) plated on opposite sides of a membrane. To better mimic the colon structure the NL side of the membrane is exposed to air to establish an air‐liquid interface. The liver mimic consists of human liver sinusoidal endothelial cells (HHSEC) and epithelial hepatic cells (HepG2 C3A) plated in Matrigel on opposite sides of a membrane. Labeled colorectal cancer cells/clusters (CA) from organoids are introduced into an established normal colon epithelial cell (NL) layer from the same patient before assembly of the system or alternatively NL organoids and fluorescently labeled CA organoids from the same patient were prepared as a ratio of 10:1 NL:CA and established together before assembly of the system. Cell viability is greater than 85% in this system. We demonstrate that over 5 days of operation that the five steps of the metastatic cascade are replicated. This novel device allows an in vitro estimate of metastatic capability (as measured by using percentages of the labeled areas per device through ImageJ) in response to selected variables. In this study, the metastatic capability depends on the source of cancer cells (e.g., the patient), the clumping of cancer cells, glucose concentration, and oxygen levels (hypoxia). For the first time, this new in vitro system mimics all five steps of the metastatic cascade in a single device and provides a new device to probe and observe the process of metastasis in a human‐based model in only 5 days. The rapid observation is due to the use of a high concentration of cancer cells in the colon (e.g. 10%) and the absence of the immune system. Our device makes it possible to probe aspects of each step of metastasis and interactions between steps.
Circulating serum miRNAs predict response to platinum chemotherapy in high‐grade serous ovarian cancer
Authors: Suzuki Kazuhiro , Yokoi Akira , Matsuzaki Juntaro , Yoshida Kosuke , Yamamoto Yusuke , Kato Tomoyasu , Ishikawa Mitsuya , Ochiya Takahiro , Kajiyama Hiroaki 
Published: November 2024

AbstractBackgroundPlatinum chemotherapy is the cornerstone of treatment for high‐grade serous ovarian cancer (HGSOC); however, validated biomarkers that can accurately predict platinum response are lacking. Based on their roles in the underlying pathophysiology, circulating microRNAs are potential, noninvasive biomarkers in cancer. In the present study, we aimed to evaluate the circulating miRNA profiles of patients with HGSOC and to assess their potential utility as biomarkers to predict platinum response.MethodsPretreatment serum samples collected from patients who received platinum chemotherapy for Stage III–IV HGSOC between 2008 and 2016 were analyzed using miRNA microarray. LASSO logistic regression analysis was used to construct predictive models for treatment‐free interval of platinum (TFIp).ResultsThe median follow‐up was 54.6 (range, 3.5–144.1) months. The comprehensive analysis of 2588 miRNAs was performed in serum samples of 153 eligible patients, and predictive models were constructed using a combination of circulating miRNAs with an area under the receiver operating characteristic curve of 0.944 for TFIp >1 month, 0.637 for TFIp ≥6 months, 0.705 for TFIp ≥12 months, and 0.938 for TFIp ≥36 months. Each predictive model provided a significant TFIp classification (p = 0.001 in TFIp >1 month, p = 0.013 in TFIp ≥6 months, p < 0.001 in TFIp ≥12 months, and p < 0.001 in TFIp ≥36 months).ConclusionCirculating miRNA profiles has potential utility in predicting platinum response in patients with HGSOC and can aid clinicians in choosing appropriate treatment strategies.
Confinement Effects of Coordination Cages on the Synthesis and Application of Polyoxometalates
Authors: Liu Cui‐Lian , Kalandia Givi , Reek Joost N. H. , Parac‐Vogt Tatjana N. 
Published: November 2024

AbstractThe confinement effects within coordination cages present powerful tools in modern chemistry, particularly for the synthesis and manipulation of complex molecules. This concept article reviews the use of coordination cages to stabilize and tune the properties of polyoxometalates (POMs), a class of nano‐sized metallic clusters, expanding the focus beyond traditional organic reactions. The article provides a brief overview of coordination cages, POM chemistry and discusses the encapsulation of POMs in coordination cages, highlighting how these cages provide a confinement effect that enhances the stability and reactivity of POMs. Additionally, the concept of cavity‐directed synthesis is explored as a method for creating labile POMs, which are often unstable in aqueous conditions, underlining its implications for supramolecular catalysis. Future research will focus on expanding the structures and applications of encapsulated POMs, as well as improving cage designs to unlock new cluster architectures.
Rationale and Design of Dual Antiplatelet Therapy in Patients with Coronary Multi‐Vessel Disease (DAPT‐MVD): A Multicenter, Randomized, Controlled Trial
Authors: Tian Jinwei , Wang Zhuozhong , Wang Yan , Wang Fan , Wang Yini , Zhao Peng , Hou Xinyu , Peng Xiang , Tian Maoyi , Wang Duolao , Yu Bo 
Published: November 2024

ABSTRACTBackgroundThe optimal duration of dual antiplatelet therapy (DAPT) for patients with coronary multi‐vessel disease (MVD) who have received drug‐eluting stents (DES) remains unclear.Hypothesis and MethodsThe Dual Antiplatelet Therapy in Patients with Coronary Multi‐Vessel Disease (DAPT‐MVD) study is a multicenter, open‐label, randomized controlled trial designed to assess the efficacy and safety of extended DAPT in MVD patients 12 months following DES implantation. We plan to enroll 8250 patients across approximately 100 sites in China. Participants will be randomized in a 1:1 ratio to receive either extended DAPT (75 mg clopidogrel plus 75–150 mg aspirin daily) or monotherapy (75–150 mg aspirin daily) beyond 12 months post‐DES implantation. The follow‐up period will last at least 12 months, with all potential endpoints adjudicated by a blinded Clinical Events Committee. The primary endpoint is major adverse cardiovascular and cerebrovascular events (MACCE), including cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke.ResultsAs of April 2024, a total of 8250 participants have been enrolled in the study. The mean age of the enrolled patients was 60.5 ± 8.8years, with 5753 (69.7%) being men.ConclusionsThe DAPT‐MVD study is the first large‐scale trial to evaluate the efficacy and safety of prolonged DAPT with clopidogrel plus aspirin beyond 12 months after DES implantation in MVD patients. The trial will provide novel insights into the optimal duration of DAPT for MVD patients (ClinicalTrials. gov ID: NCT04624854. Registered on 10/27/2020).
Coordination Compounds as Antivirals against Neglected Tropical Diseases
Authors: Rezende Wallace S. , Neto Antonio Marçal , Corbi Juliano J. , Corbi Pedro P. , de Paiva Raphael E. F. , Bergamini Fernando R. G. 
Published: November 2024

AbstractNeglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen‐related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate‐to‐cold environments. The slow‐paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS‐CoV‐2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod‐borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.
Considerations in screening for asymptomatic carotid artery stenosis in irradiated head and neck cancer survivors
Authors: Day Andrew T. , Mitchell Dalia N. , Eary Rebecca L. , Jones Erica , Pinho Marco C. , Zaha Vlad G. , Yang Eric H. , Sher David J. 
Published: November 2024

Carpenter et al. add to the body of evidence demonstrating that irradiated head and neck cancer survivors are at high risk for carotid artery stenosis. In this editorial, the concept of screening for asymptomatic carotid artery stenosis in this subpopulation is explored.
Pharmacokinetics and Bioequivalence Evaluation of Trazodone Hydrochloride Sustained‐Release Tablets in Healthy Chinese Volunteers
Authors: Wang Jingyan , Xu Yuan , Zhao Zhicheng , Meng Tian , Zou Yang , Lan Yi 
Published: November 2024

AbstractThe aim of this study was to investigate the pharmacokinetics, bioequivalence, and safety of generic trazodone hydrochloride sustained‐release tablet and its reference listed product in healthy Chinese subjects. An open, randomized, single‐dose, and 2‐period crossover study was involved under fasting and fed conditions, with a 7‐day washout period. A single oral dose of 150 mg of 2 trazodone hydrochloride sustained‐release tablets was administered to 84 healthy volunteers, with 36 in the fasting group and 48 consuming a high‐fat diet, respectively. The plasma concentrations of trazodone were analyzed using a liquid chromatography‐tandem mass spectrometry method, and pharmacokinetic parameters were obtained from concentration‐time profiles. The geometric mean ratio with 90% confidence intervals of the maximum trazodone concentration, area under the plasma concentration‐time curve (AUC) from time 0 to the last measurable concentration, and AUC from time 0 to infinity were within the bioequivalence acceptance criteria (80%‐125%) under fasting and fed conditions, which indicated that the test and reference formulations were bioequivalent. Compared with the fasting study, the concomitant administration of trazodone with a high‐fat diet had a negligible influence on the drug pharmacokinetic behavior. Adverse events were recorded, and no serious adverse events were observed during either fasting or fed conditions. Trazodone has proven to have an acceptable safety profile in the Chinese population, with bioequivalence successfully established under both fasting and fed conditions.