bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Antimicrobial Electrotherapy and Wound Monitoring Hydrogel with Bimetal Phenolic Networks for Smart Healthcare
Authors: Yang Qin , Chen Rong , Li Mingzi , Song Hongzhao , Zhao Xiaoying , Zhang Liang , Zhou Yuanzhen , Chen Jiao , Li Jianli , Chen Mi 
Published: October 2024

AbstractThe design and fabrication of novel soft bioelectronic materials for rapid wound healing and real‐time monitoring are critical for smart healthcare. However, developing such integrated multifunctional materials devices remains challenging due to fabrication dynamics and sensing interface issues. Herein, a novel strategy is presented for accelerating the kinetics of hydrogels integrating antimicrobial, electrotherapeutic, and wound monitoring functions via bimetallic phenolic networks. The Al3+ catalyzes the radical copolymerization reaction of acrylic acid, resulting in the gelation of the system within 10 s, and also catalyzes the redox reaction between silver and lignin, inducing the sustained release of catechol, which significantly enhances the hydrogel's antimicrobial activity and shortened the wound healing process. Meanwhile, the abundant non‐covalent interactions enhance the hydrogel's tissue adhesion, and mechanical properties (tensile strength 1.558 MPa and elongation 1563%). In addition, the bimetallic ions endow the hydrogels with excellent sensing properties. Under the synergy of electrical stimulation, the wound healing rate is accelerated. Notably, wound assessment can be performed by monitoring changes in electrical signals over the wound, which can assist physicians and patients in achieving intelligent wound management. This work provides new insights into the design and application of multifunctional smart bioelectronic materials.
A Multisite Atomic‐Oxygen Anchoring Strategy Affords Efficient and Stable Perovskite Solar Cells
Authors: Li Mingguang , Pan Wenjing , Zhao Lian , Wan Wei , Deng Yong , Guo Ke , Yang Wenhan , He Ling‐Jun , Chen Runfeng , Wu Guangbao 
Published: October 2024

AbstractLewis base molecules are widely used to passivate structural defects in perovskites. However, the spatial compatibility between these molecules and the perovskite lattice is seldom considered. Herein, a multisite atomic‐oxygen (O) anchoring passivation strategy using 1,1,2,2‐tetra(4‐methoxyphenyl)ethene (TMPE), which contains four electronegative O atoms to selectively anchor iodine vacancies and passivate under‐coordinated Pb2+ or MA+ defects is proposed. It is found that the distance between any three O atoms in a TMPE molecule matches that of iodine ions in the lattice structure, thereby maximizing passivation effects and enhancing lattice stability. Additionally, the coordination of TMPE facilitates the formation of larger colloid sizes in the precursor solution, effectively regulating crystal growth. Due to the molecular extrusion effect, TMPE‐based anchors localize on the surface, passivating defects and mitigating nonradiative recombination. As a result, defects in MA‐based and FA‐based perovskite films are significantly reduced, achieving optimized power conversion efficiencies (PCEs) of 19.9% and 24.5%, while exhibiting exceptional stability by retaining 90% of initial PCE after 1200 h of storage without encapsulation. This single molecule‐controlled perovskite multisite anchoring strategy would help resolve lattice stability issue caused by perovskite defects, thereby paving the pathway for the development of high‐performance and highly stable perovskite solar cells.
Tailoring Carrier Dynamics of BiVO4 Photoanode via Dual Incorporation of Au and Co(OH)x Cooperative Modification for Photoelectrochemical Water Splitting
Authors: Chen Xinchao , Li Xiang , Peng Youming , Yang Hao , Tong Yexiang , Balogun M.‐Sadeeq , Huang Yongchao 
Published: October 2024

AbstractPhotoelectrochemical solar to hydrogen production is a promising way to achieve carbon neutrality, but severe charge recombination in photoanodes limits the conversion efficiency. Herein, Au nanoparticles and Co(OH)x co‐sensitized bismuth vanadate (BiVO4) to construct AuCo(OH)x/BiVO4 photoanode for significantly enhancing the performance of photoelectrochemical water splitting. This process significantly improves the bulk charge carrier separation efficiency, the surface kinetics of water oxidation, and the electron density of BiVO4 photoanode through Au surface plasmon resonance (SPR) and Co(OH)x oxygen evolution catalysts effect. Additionally, the enhancement of the *O and the *OOH generation accelerate the oxygen evolution reaction kinetics. Consequently, the constructed AuCo(OH)x/BiVO4 photoanode demonstrates an excellent photocurrent of 6.2 mA cm−2 at 1.23 V versus reversible hydrogen electrode and a stable continuous output within 42 h. This work contributes to developing high‐efficiency and high‐stability photoanodes for solar H2 production through SPR effect and oxygen evolution catalysts.
Cell‐Shearing Chemistry Directed Closed‐Pore Regeneration in Biomass‐Derived Hard Carbons for Ultrafast Sodium Storage
Authors: Lan Nan , Shen Yushan , Li Jingyi , He Hanna , Zhang Chuhong 
Published: October 2024

AbstractThe closed‐pore structure of hard carbons holds the key to high plateau capacity and rapid diffusion kinetics when applied as sodium‐ion battery (SIB) anodes. However, understanding and establishing the structure‐electrochemistry relationship still remains a significant challenge. This work, for the first time, introduces an innovative deep eutectic solvent (DES) cell‐shearing strategy to precisely tailor the cell structure of natural bamboo and consequently the closed‐pore in its derived hard carbons. The DES shearing force effectively modifies the pore architecture by simultaneously shearing and dissolving amorphous components to form closed pore cores with adjustable sizes, as well as disintegrating crystalline cellulose through generation of competing hydrogen bonds to elaborately tune the pore wall thickness and ordering. The optimized closed‐pore structure featuring appropriate pore size (∼2 nm) and ultra‐thin (1–3 layers) disordered pore walls, exhibits abundant active sites and delivers rapid ion diffusion kinetics and high reaction reversibility. Consequently, a high reversible capacity of 422 mAh g−1 at 30 mA g−1 along with an exceptional rate capability (318.6 mAh g−1 at 6 A g−1) are achieved, outperforming almost all previous reported hard carbons. The new concept of cell‐shearing chemistry for closed‐pore regeneration significantly advances the applications of biomass materials for energy storage.
Ferric‐Tannic Nanoparticles Inhibit Early‐Stage Hepatocarcinogenesis by Activating Tumor Immune Responses in Rats
Authors: Intakhad Jannarong , Vachiraarunwong Arpamas , Wongpoomchai Rawiwan , Pilapong Chalermchai 
Published: October 2024

AbstractEarly diagnosis and treatment of hepatocellular carcinoma (HCC) remain major challenges. Significant efforts have been made to find new approaches to address these issues. Ferric‐tannic nanoparticles (FTs) have emerged as promising tools for targeting the early phase of hepatocarcinogenesis due to their preferential accumulation in preneoplastic liver lesions. In this study, the therapeutic potential of FTs is demonstrated in early‐stage hepatocarcinogenesis in rats. FTs inhibit the progression of early hepatocarcinogenesis, reducing hepatic nodules, preneoplastic foci (glutathione S‐transferase placental (GST‐P) form‐positive foci), and HCC cell proliferation. The therapeutic effects of FTs appear to be mediated by inhibiting cell proliferation through the activation of immune responses. FTs show promise as novel immunomodulators or therapeutic agents for the treatment of early‐stage HCC.
Adipose Tissue‐Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway
Authors: Zhu Yucheng , Yang Ruiqi , Deng Zhangchao , Deng Bohua , Zhao Kun , Dai Chen , Wei Gang , Wang YanJiang , Zheng Jinshui , Ren Zhuqing , Lv Wentao , Xiao Yingping , Mei Zhinan , Song Tongxing 
Published: October 2024

AbstractObesity represents a low‐grade chronic inflammation status, which is associated with compromised adaptive thermogenesis. However, the mechanisms underlying the defective activation of thermogenesis in chronic inflammation remain unclear. Here, a chronic inflammatory model is first estabolished by injecting mice with low‐dose lipopolysaccharide (LPS) before cold exposure, and then it is verified that LPS treatment can decrease the core body temperature of mice and alter the microbial distribution in epididymal white adipose tissue (eWAT). An adipose tissue‐resident bacterium Sphingomonas paucimobilis is identified as a potential inhibitor on the activation of brown fat and browning of inguinal WAT, resulting in defective adaptive thermogenesis. Mechanically, LPS and S. paucimobilis inhibit the production and release of 15‐HETE by suppressing its main metabolic enzyme 12 lipoxygenase (12‐LOX) and 15‐ Hydroxyeicosatetraenoic acid (15‐HETE) rescues the impaired thermogenesis. Interestingly, 15‐HETE directly binds to AMP‐activated protein kinase α (AMPKα) and elevates the phosphorylation of AMPK, leading to the activation of uncoupling protein 1 (UCP1) and mitochondrial oxidative phosphorylation (OXPHOS) complexes. Further analysis with human obesity subjects reveals that individuals with high body mass index displayed lower 15‐HETE levels. Taken together, this work improves the understanding of how chronic inflammation impairs adaptive thermogenesis and provides novel targets for alleviating obesity.
Single‐Cell RNA Sequencing Uncovers Pathological Processes and Crucial Targets for Vascular Endothelial Injury in Diabetic Hearts
Authors: Zhang Yan , Cao Yang , Zhang Xuebin , Lin Jie , Jiang Mengyuan , Zhang Xiao , Dai Xinchun , Zhang Xiaohua , Liu Yue , Ge Wen , Qiang Huanhuan , Li Congye , Sun Dongdong 
Published: October 2024

AbstractCardiovascular disease remains the leading cause of high mortality in individuals with diabetes mellitus. Endothelial injury is a major contributing factor for vascular dysfunction in diabetes. However, the precise mechanisms underlying endothelial cell injury and their heterogeneity in diabetes remains elusive. In this study, single‐cell sequencing is performed in heart tissues from leptin receptor knock‐out (db/db) diabetic mice at various pathological stages. Through cell cluster identification, differential gene analysis, intercellular communication analysis, pseudo time analysis, and transcription factor analysis, a novel mechanism of cardiac vascular endothelial damage in diabetes is identified. Specifically, a single‐cell transcription map of cardiac vascular endothelial cells is presented in db/db mice. Diverse cellular clusters are found to play vital roles under diabetes‐induced damage, highlighting crucial transcription factors involved in their regulation. In addition, the essential transcription factor Ets1 is found to protect against vascular endothelial injury in db/db mice. In summary, the work provides a comprehensive understanding of the development of diabetic cardiac vascular endothelial damage and the heterogeneity of the cells involved. These findings offer valuable insights into potential treatments and assessments of diabetic cardiovascular endothelial damage.
High‐Strength and High‐Temperature‐Resistant Structural Battery Integrated Composites via Polymeric Bi‐Continuous Electrolyte Engineering
Authors: Xun Lijiao , Li Chen , Meng Qinghai , Wang Zilong , Guo Ying , Zheng Kun , Zhou Heng , Zhao Tong 
Published: October 2024

AbstractStructural battery integrated composites (SBICs) combining outstanding strength and heat resistance are highly desirable candidates for next generation high speed aircraft. Here, a novel high‐temperature‐resistant bi‐continuous electrolyte based on phthalonitrile resin is presented, allowing the construction of SBICs capable of stable operation across a wide temperature range. Excellent mechanical strength and high ionic conductivity can coexist in a bi‐continuous structure electrolyte (PL50) where the phthalonitrile resin serves as the matrix phase and the ionic liquid electrolyte serves as the conductive phase. Benefiting from the thermal stability of the phthalonitrile resin, SBICs assembled with a PL50 bi‐continuous electrolyte deliver excellent mechanical performance even at temperatures exceeding 200 °C, with a flexural strength of 299 MPa and a flexural modulus of 31.8 GPa. Additionally, with an increase in operating temperature, PL50@SBICs demonstrated enhanced rate performance while maintaining good cycling stability. The demonstration of resisting mechanical abuse at high temperatures and flame retardance further suggests the promise of SBICs with PL50 bi‐continuous electrolytes operating under extreme conditions.
Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression
Authors: Gan Yu , Hao Qian , Han Tao , Tong Jing , Yan Qingya , Zhong Hongguang , Gao Bo , Li Yanan , Xuan Zhisheng , Li Pengfei , Yao Litong , Xu Yingying , Jiang Yi‐Zhou , Shao Zhi‐Ming , Deng Jun , Chen Jiaxiang , Zhou Xiang 
Published: October 2024

AbstractElevated ribosome biogenesis correlates with the rapid growth and progression of cancer. Targeted blockade of ribosome biogenesis induces nucleolar stress, which preferentially leads to the elimination of malignant cells. In this study, it is reported that the nucleolar protein BRIX1 is a critical regulator for the homeostasis between ribosome biogenesis and p53 activation. BRIX1 facilitated the processing of pre‐rRNA by supporting the formation of the PeBoW complex. In addition, BRIX1 prevented p53 activation in response to nucleolar stress by impairing the interactions between MDM2 and the ribosomal proteins, RPL5, and RPL11, thereby triggering the resistance of cancer cells to chemotherapy. Conversely, depletion of BRIX1 induced nucleolar stress, which in turn activated p53 through RPL5 and RPL11, consequently inhibiting the growth of tumors. Moreover, engineered exosomes are developed, which are surface‐decorated with iRGD, a tumor‐homing peptide, and loaded with siRNAs specific to BRIX1, for the treatment of cancer. iRGD‐Exo‐siBRIX1 significantly suppressed the growth of colorectal cancer and enhanced the efficacy of 5‐FU chemotherapy in vivo. Overall, the study uncovers that BRIX1 functions as an oncoprotein to promote rRNA synthesis and dampen p53 activity, and also implies that targeted inhibition of BRIX1 via engineered exosomes can be a potent approach for cancer therapy.
Artificial Microglia Nanoplatform Loaded With Anti‐RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke
Authors: Cheng Ruiqi , Luo Xiaoqin , Wu Xiaohui , Wang Zijie , Chen Ziqun , Zhang Shaoru , Xiao Hongmei , Zhong Jiaju , Zhang Rongrong , Cao Yang , Qin Xinyue 
Published: October 2024

AbstractIschemic stroke is a leading cause of death and disability worldwide, and the main goals of stroke treatment are to destroy the thrombus to recanalize blood vessels and protect tissue from ischemia/reperfusion injury. However, current recanalization therapies have serious limitations and there are few neuroprotection methods. Hence, an artificial nanoplatform loaded with anti‐Repulsive Guidance Molecule a monoclonal antibody (anti‐RGMa) and coated with microglia membrane (MiCM) is reported for stroke treatment, namely MiCM@PLGA/anti‐RGMa/Fe3O4@PFH (MiCM‐NPs). Tail vein injection of MiCM‐NPs targeted the ischemia‐damaged endothelial cells because of the MiCM, then superparamagnetic iron oxide (Fe3O4) and anti‐RGMa are released after external low‐intensity focused ultrasound (LIFU) exposure. The thrombus is destroyed by LIFU‐induced “liquid‐to‐gas” phase transition and cavitation of perfluorohexane (PFH) as well as Fe3O4 movements induced by an external magnetic field. Anti‐RGMa protected the ischemic region from ischemia/reperfusion injury. The nanoplatform enabled visualization of the thrombus by ultrasound/photoacoustic imaging when the clot is in an extracranial artery. Importantly, in vivo animal studies revealed good safety for MiCM‐NPs treatment. In conclusion, this nanoplatform shows promise as an ischemic stroke treatment strategy combining targeted delivery, recanalization, and neuroprotection.
Preparation, optimization, and modification of urea‐formaldehyde resin for used as a plugging agent in fractured and caved oil and gas reservoirs
Authors: Bojian Zhang , Youquan Liu , Ying Xiong , Cheng Fu , Wang Xianbing 
Published: October 2024

AbstractBased on the requirements of resin‐based plugging agents on initial viscosity, gel time and cost, the urea‐formaldehyde resin Poly‐UF was synthesized via aqueous solution polymerization. Subsequently, the Poly‐UF was further modified by using melamine, polyvinyl alcohol (PVA), and oxidized starch to enhance its application performances, which were marked by Poly‐UF‐M, Poly‐UF‐PVA and Poly‐UF‐OS, respectively. Simultaneously, the relationship between the preparation process, structural, and performance characteristics of the different resin types was investigated using a single‐factor experimental approach, specifically, the solid content, viscosity, and free formaldehyde content were evaluated to gauge its application performance. In this study, the chemical structure, thermal stability and microscopic morphology of Poly‐UF‐M, Poly‐UF‐PVA and Poly‐UF‐OS were studied by using FTIR, TG‐DTG and SEM. As a result, it was confirmed that the Poly‐UF was successfully modified, and the thermal stability was obviously improved, and the microstructure was further enhanced by melamine, PVA and oxidized starch. The outcomes revealed a notable reduction in free formaldehyde content and a significant increase in solid content for Poly‐UF‐M, Poly‐UF‐PVA, and Poly‐UF‐OS, specifically, the free formaldehyde content decreased by 47.15%, 36.59%, and 32.52%, respectively, while the solid content increased by 3.47%, 1.62%, and 1.39%, respectively. Moreover, the acid and alkali solubility, mechanical strength of cured Poly‐UF‐M, Poly‐UF‐PVA and Poly‐UF‐OS were improved attribute to excellent membrane‐forming performance. The innovation of this study is that the systematic investigation and optimization of urea‐formaldehyde resin are presented, providing technical insights on its utilization as a plugging agent in fractured and caved oil and gas reservoirs.
Selective separation of dyes and tetracycline hydrochloride in polymer‐nucleotide coacervate droplets
Authors: Zhu Chuntao , Yu Meng , Liang Zijian , Zhang Lanhe , Zhang Jian 
Published: October 2024

AbstractThis paper reports the formation of coacervates by the electrostatic interaction of poly (diallyldimethylammonium chloride) (PDDA) and adenosine triphosphate (ATP) in aqueous solution, examining its formation conditions, stability, and efficiency in separation. The ideal concentration for creating coacervate droplets in pure water, HEPES buffer, and NaCl solution was determined to be 20 mM of PDDA and ATP. Enhancing the stability of coacervates was achieved by incorporating phospholipid vesicles on their surface, presenting a novel strategy for building cell models. Ostwald Ripening was employed to comprehend the growth mechanism of the coacervates, while the Hofmeister Ion Series and Schulze‐Hardy's rule were utilized to elucidate the stability differences in solutions containing NaCl, Na2SO4, and MgCl2. These coacervates were stable at concentrations below 90 mM NaCl, 200 mM Na2SO4, and 30 mM MgCl2, respectively. We also explored the specific separation of dyes and tetracycline hydrochloride (TC) in the coacervates. Separation efficiencies of 92.98% for methylene blue (MB), 94.19% for methyl orange (MO), and 85.94% for TC, were achieved by the coacervates, which can be attributed to the synergistic effects of hydrophobicity, electrostatic forces, and π‐π interactions. The proposed coacervates have great potential in cell mimicry and water treatment.
Synthesis and thermal behavior of acrylonitrile/guanidine crotonate copolymer for carbon fiber precursor
Authors: Wang Yuhang , Malik Hamza , He Jian , Zhang Hui , Liu Yong , Yu Jianyong 
Published: October 2024

AbstractThe thermal oxidation stabilization of polyacrylonitrile (PAN) copolymer is a highly exothermic process. It significantly impacts the quality of the finished PAN‐based carbon fiber, which is often addressed by adding appropriate comonomers. This paper synthesized guanidine crotonate (GCA) as a comonomer and copolymerized with acrylonitrile (AN) to prepare P(AN‐GCA). DSC analysis revealed that when compared to PAN and P(AN‐CA) copolymers, the initial exothermic temperature, maximum exothermic heat flux, and heat flux of P(AN‐GCA) copolymer were greatly reduced. FT‐IR spectroscopy showed that the degree of pre‐oxidation increased with the increasing comonomer GCA content, indicating that the addition of comonomer GCA could promote PAN pre‐oxidation cyclization and improve the copolymer's degree of pre‐oxidation. The activation energies of PAN and P(AN‐GCA) were 160 and 126 KJ/mol, respectively. It was shown that the addition of GCA could effectively reduce the activation energy of the cyclization reaction of the polymer while simultaneously promoting it. TGA analysis shows that the introduction of GCA improves the copolymer's thermal stability, and the yield at 800°C is more than 54%, which is at least 19% higher than PAN homopolymer. P(AN‐GCA) has the potential to be carbon fiber precursor.
Fracture‐mechanical properties of tailored epoxy nanocomposites at elevated temperatures
Authors: Bajpai Ankur , Alapati Arun Kumar , Davidson James R. , Saxena Prateek , Wetzel Bernd 
Published: October 2024

AbstractAn investigation was conducted to assess the influence of hybridized block‐copolymer (BCP) and core–shell rubber (CSR) particles on the tensile properties, fracture mechanical properties, and toughening mechanisms of a high strength epoxy/anhydride system at elevated temperatures (80°C). Utilizing standard tensile and compact tension (CT) specimens, substantial increases in fracture energy were observed for specimens enhanced with nanoparticles—831% for the 4 wt.% BCP‐toughened system and 600% for the 12 wt.% CSR‐toughened system. Field emission gun–scanning electron microscope imaging indicated that the inclusion of BCP and CSR significantly altered fracture surface morphologies, consistent with the improved mechanical properties. Glass transition temperature (Tg) determined through dynamic mechanical analysis—were not significantly influenced by additive inclusion, presenting a ~1°C decrease for BCP and ~3°C increase for CSR toughened systems relative to the unaltered matrix. Toughening mechanisms induced by the BCP and CSR particles were identified as (a) localized enhanced plastic shear‐band yielding around the particles and (b) cavitation of the particles followed by enhanced plastic void growth in the epoxy matrix. Outcomes from this study highlight the role of BCP and CSR particles in the toughening of epoxy/anhydride systems and provide a comprehensive assessment of their influence on mechanical characteristics at high temperatures.