bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Atrial Fibrillation with Insomnia in the Elderly Population
Authors: Nguyen Justin , Mookerjee Neil , Koirala Prashant , Schmalbach Nicole , Antinori Gianna , Thampi Subhadra , Windle-Puente Dylan , Gilligan Amy , Huy Ha , Andrews Megha , Sun Angela , Gandhi Roshni , Benedict William , Chang Austin , Sanders Ben , Keesara Maanika Reddy , aliev Janet , Patel Aneri , Hughes Isaiah , Millstein Ian , Hunter Krystal , Roy Satyajeet 
Published: November 2024

Introduction/Objectives: Insomnia is a common sleep disorders that affects most individuals in the United States, and worldwide. Insomnia is linked with an increased risk of atrial fibrillation (AF) in adults, although the strengths of association were weak, especially in the elderly population. AF is estimated to affect approximately 3 to 6 million people in the United States. We studied the association of AF with insomnia in the elderly population. Methods: We reviewed the electronic medical records of elderly patients who received care in an internal medicine office from July 1, 2020 through June 30, 2021. Patients were grouped into AF group, and a group without AF (NOAF). Association of insomnia and other variables were compared between the 2 groups. Results: Among 2428 patients, 341 (14%) had AF. Patients in the AF group were significantly older compared to no-AF group (80.3 ± 7.9 vs 76.1 ± 7.4 years; P < .001). A higher frequency of men was noted in AF group versus NOAF group (54.3 vs 42.0%; P < .001). The frequency of insomnia was significantly higher in AF group versus NOAF group (14.1 vs 9.5%; P < .05). Additionally, greater frequencies of associations of other comorbid medical conditions were noted in the AF group compared to NOAF group, such as cerebrovascular accident (CVA; 12.9 vs 5.4%; P < .001), transient ischemic attack (TIA; 7.0 vs 3.0%; P < .001), dementia (5.9 vs 3.3%; P < .05), coronary artery disease (CAD; 34.9 vs 18.3%; P < .001), congestive heart failure (CHF; 21.1 vs 3.8%; P < .001), other cardiac arrhythmias (53.4 vs 6.3%; P < .001), chronic obstructive pulmonary disease (COPD; 12.3 vs 5.7%; P < .001), obstructive sleep apnea (OSA; 17.6 vs 11.8%; P = .003), chronic kidney disease (CKD; 22.9 vs 11.9%; P < .001), anemia (23.2 vs 13.0%; P < .001), and cancer (36.1 vs 27.9%; P = .002). There was significantly greater odds of AF in patients who had insomnia (OR = 1.972, CI = 1.360-2.851; P < .001). Conclusion: AF was associated with insomnia in the elderly population. Higher frequencies of association of AF were also seen with older age, male sex, White race, CVA, TIA, dementia, CAD, CHF, other cardiac arrhythmias, COPD, OSA, CKD, anemia, and cancer.
Perspectives on drug development in chronic myelomonocytic leukemia: changing the paradigm
Authors: Hunter Anthony M. , Patnaik Mrinal M. , Itzykson Raphael , Mesa Ruben , Karanes Chatchada , Li Yanxia , de Claro R. Angelo , Norsworthy Kelly J. , Theoret Marc , Pulte Elizabeth , Padron Eric 
Published: November 2024

Abstract
Drug development for chronic myelomonocytic leukemia (CMML) has failed to parallel the recent success observed in related myeloid neoplasms. To address these shortcomings, the US Food and Drug Administration (FDA) held a “Mini-symposium on CMML: Current State of the Art and Trial Design” in September 2023. This symposium brought together a panel of key FDA regulators and academic experts in CMML drug development to discuss challenges and provide perspectives on future drug development for this disease. The panel explored unique challenges that underlie the lack of therapeutic advances in CMML to date and discussed relevant topics such as clinical trial design, study end points, and key regulatory considerations. This article summarizes the key points of discussion from this symposium to facilitate advancements in the field.
Weight-based disparities in perinatal care: quantitative findings of respect, autonomy, mistreatment, and body mass index in a national Canadian survey
Authors: Malhotra Nisha , Jevitt Cecilia M. , Stoll Kathrin , Phillips-Beck Wanda , Vedam Saraswathi ,   the RESPCCT Study Team
Published: November 2024

Abstract
Background
Qualitative studies document episodes of weight-related disrespectful care, particularly for people with high body mass index (BMI ≥ 30) and reveal implicit and explicit biases in health care providers. No large quantitative studies document the pervasiveness of weight stigma or if experiences change with increasing BMI.

Methods
The multi-stakeholder RESPCCT study team designed and distributed a cross-sectional survey on the experiences of perinatal services in all provinces and territories in Canada. From July 2020 to August 2021, participants who had a pregnancy within ten years responded to closed and open-ended questions. Chi square analysis assessed differences in mean scores derived from three patient-reported experience measures of autonomy (MADM), respect (MOR), and mistreatment (MIST). Controlling for socio-demographic factors, multivariate logistic regression analysis explored relationships between different BMI categories and respectful care.

Results
Of 4,815 Canadians who participated, 3,280 with a BMI of ≥ 18.5 completed all the questions. Pre-pregnancy BMI was significantly associated with race/ethnicity, income sufficiency, and education but not with age. Individuals with higher BMIs were more likely to experience income insufficiency, have lower levels of education, and more frequently self-identified as Indigenous or White. Those with BMI ≥ 35 exhibited notably higher odds of reduced autonomy (MADM) scores, with an unadjusted odds ratio of 1.62 and an adjusted odds ratio of 1.45 compared to individuals with a normal weight. Individuals with BMIs of 25–25.9, 30–34.9, and ≥ 35 exhibited odds of falling into the lower tercile of respect (MOR) scores of 1.34, 1.51, and 2.04, respectively (p < .01). The odds of reporting higher rates of mistreatment (top 33% MIST scores) increased as BMI increased.

Conclusions
While socio-demographic factors like race and income play significant roles in influencing perinatal care experiences, BMI remains a critical determinant even after accounting for these variables. This study reveals pronounced disparities in the provision of respectful perinatal care to pregnant individuals with higher BMIs in Canada. Data suggest that those with higher BMIs face disrespect, discrimination, and mistreatment. Identification of implicit and explicit weight bias may give providers insight enabling them to provide more respectful care.
Art and design workshops at a residential care facility – social care professionals’ experiences of co-creation and participation in designing the physical environment
Authors: Wikström Ewa , Dahlin-Ivanoff Synneve , Gunn Maja , Lood Qarin 
Published: November 2024

Abstract
Background
Co-creation and participation among different user groups have been highlighted as pivotal for improving residential care facilities for older persons. However, more knowledge is needed on methods aiming to overcome challenges in constructing inclusive co-creation and participation processes. In particular, there is a need for knowledge concerning how art and design workshops could contribute to co-creation and participation of social care professionals designing the physical environment in residential care facilities. Therefore, this study aimed to examine how art and design workshops can contribute to co-creation and participation in designing the physical environment with residential care facility professionals.

Methods
A qualitative method was used to investigate social care professionals’ experiences. Data were collected through semi-structured group interviews and analysed with inspiration from Corbin and Strauss’s analysis method.

Results
This study concludes that art and design workshops could serve as deliberating and developing practices. First, the art and design workshop as a deliberating practice involves conditions that create a communication arena and space supporting professionals in sharing experiences and voicing different perspectives. Second, the art and design workshop, as a developing practice, supports shared agency through dialogue focusing on designing the physical environment in residential care facilities, using photographs, materials, and fabrics.

Conclusions
This research contributes to the understanding of the relevance of art and design workshops and co-creation between artists and social care professionals in designing the physical environment in residential care facilities. The study can be valuable in identifying important mechanisms that facilitate co-creation and participation among social care professionals, as well as the development of art and design as a tool for improving environments in residential care facilities. The research focuses on how art and design workshops could influence co-creation and participation through art and design from the perspective of social care professionals.
The politics of health systems policies during COVID-19: reflections on experiences from Latin America and the Caribbean
Authors: Flores Walter , Sullivan Alexis , Jerez Fernando , Rodríguez Daniela C. 
Published: November 2024

AbstractPolitics as the exercise of power always influence public policies–which reflects the multifaceted nature of decision-making–but “using politics” as a motivation for self-serving interests of government leaders and their allies poses problems. This article reviews the impacts of COVID-19 on health systems of the Latin American and Caribbean region from a political lens. We highlight the overriding influence of politics in health policies, weak governance structures that became compromised, exacerbation of corruption, and breakdowns in the communication and trust between governments and their citizens. There are many factors that did not work well-or as expected. For instance, the poor predictive ability of the Global Health Security Index, which showed that pre-pandemic assessments were deeply naive to how health systems evidence and expertise are uniquely vulnerable to politics. We argue that there is an urgent need to rethink health policy and systems frameworks-including metrics-at national and global level. There is also a need for new global health governance arrangements. The expected solidarity and collaboration among countries was trumped by the rich countries practice of gauging essential resources and vaccines and applying health diplomacy to the rest of the world, and the unchecked power of commercial corporations producing essential medical supplies and vaccines.
Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
Authors: Radaelli Antonia , Zanotto Carlo , Brambilla Chiara , Adami Tommaso , Paolini Francesca , Venuti Aldo , Manuka Adriana , Mehmeti Irsida , De Giuli Morghen Carlo 
Published: November 2024

AbstractAlthough not as lethal as variola virus (VARV), the cause of smallpox, monkeypox virus (MPXV) represents a threat to public health, with important infection rates and mortality in several African countries and signs of spreading worldwide. MPXV may establish new reservoirs in non-endemic countries and can be considered a possible biological weapon. Human-to-human MPXV transmission is increasing with a growing susceptibility, coincident with the declining herd immunity against smallpox. The emerging threat of MPXV highlights the urgent need for protection from new zoonotic infections, as mankind is completely unprepared for encounters with new viruses. Preventive vaccination remains the most effective control against orthopoxviruses (OPXVs) such as MPXV and prime-boost vaccination strategies can significantly influence vaccine efficacy and enhance immune responses. Our study aimed at characterizing potential vaccine candidates against OPXV infections in a murine model using DNA, viral and protein recombinant vaccines using different prime-boost regimens. The experiments employed Vaccinia virus (VACV) A33, B5, L1, and A27 envelope proteins as immunogens for both priming and boosting. Priming was carried out using a mixture of four plasmids (4pVAXmix), and boosts employed fowlpox (FWPV) recombinants (4FPmix) and/or the purified recombinant proteins (4protmix), all of them expressing the same antigens. One or two doses of the same immunogens were tested and identical protocols were also compared for intranasal (i.n.) or intramuscular (i.m.) viral administration, before challenge with the highly pathogenic VACV VVIHD−J strain. Our results show that a single dose of any combined immunogen elicited a very low antibody response. Protein mixtures administered twice boosted the humoral response of DNA immunizations by electroporation (e. p.), but did not protect from viral challenge. The antibody neutralizing titer was inversely correlated with animals’ weight loss, which was initially similar in all of the groups after the challenge, but was then reversed in mice that had been primed twice with the DNA recombinants and boosted twice with the FWPV recombinants.
The efficacy of fiber-supplemented enteral nutrition in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Authors: Koch Jana Larissa , Lew Charles Chin Han , Kork Felix , Koch Alexander , Stoppe Christian , Heyland Daren K. , Dresen Ellen , Lee Zheng-Yii , Hill Aileen 
Published: November 2024

Abstract
Background
Evidence on the benefits of fiber-supplemented enteral nutrition (EN) in critically ill patients is inconsistent, and critical care nutrition guidelines lack recommendations based on high-quality evidence. This systematic review and meta-analysis (SRMA) aims to provide a current synthesis of the literature on this topic.

Methods
For this SRMA of randomized controlled trials (RCT), electronic databases (MEDLINE, EMBASE, CENTRAL) were searched systematically from inception to January 2024 and updated in June 2024. Trials investigating clinical effects of fiber-supplemented EN versus placebo or usual care in adult critically ill patients were selected. Two independent reviewers extracted data and assessed the risk of bias of the included studies. Random-effect meta-analysis and trial sequential analysis (TSA) were conducted. The primary outcome was overall mortality, and one of the secondary outcomes was diarrhea incidence. Subgroup analyses were also performed for both outcomes.

Results
Twenty studies with 1405 critically ill patients were included. In conventional meta-analysis, fiber-supplemented EN was associated with a significant reduction of overall mortality (RR 0.66, 95% CI 0.47, 0.92, p = 0.01, I2 = 0%; 12 studies) and diarrhea incidence (RR 0.70, 95% CI 0.51, 0.96, p = 0.03, I2 = 51%; 11 studies). However, both outcomes were assessed to have very serious risk of bias, and, according to TSA, a type-1 error cannot be ruled out. No subgroup differences were found for the primary outcome.

Conclusion
Very low-certainty evidence suggests that fiber-supplemented EN has clinical benefits. High-quality multicenter RCTs with large sample sizes are needed to substantiate any firm recommendation for its routine use in this group of patients.
PROSPERO registration number: CRD42023492829.
A panoramic view of the molecular epidemiology, evolution, and cross-species transmission of rosaviruses
Authors: Zhang Minyi , Fan Shunchang , Liang Minyi , Wu Ruojun , Tian Jingli , Xian Juxian , Zhou Xiaofeng , Chen Qing 
Published: November 2024

AbstractRosavirus is a newly discovered member of the family Picornaviridae that was initially detected in wild rodents and subsequently in children with diarrhoea. Nevertheless, there is a significant gap in our understanding of the geographical distribution, phylogenetic relationships, evolutionary patterns, and transmission of rosaviruses. To address these issues, we analysed 434 rodents and shrews from five different species that were collected in southern China. Using PCR screening of faecal samples, we detected rosaviruses in Norway rats (Rattus norvegicus) and identified two previously undocumented host species: tanezumi rats (Rattus tanezumi) and Asian house shrews (Suncus murinus). Rosaviruses were particularly common in these animals, with an overall prevalence rate of 32.49% (141/434). For genetic and evolutionary analyses, we selected six representative positive samples to amplify the complete genomes of rosaviruses. Bayesian phylogenetic analysis suggested that our sequences clustered within the genus Rosavirus, where genotype B sequences are the closest relatives. The elevated nonsynonymous-to-synonymous ratios observed in rosavirus B may be attributed to relaxed selection pressures driven by virus spillover events. On the basis of the available data, it is hypothesized that the genus Rosavirus may have originated from Norway rats around the year 1339. In summary, these findings provide valuable insights into the complex evolutionary history of rosaviruses and underscore the urgent need for ongoing surveillance of this virus.
Hydraulic properties for a wide range of undisturbed and compacted French forest soils: in situ measurements and estimation with the BEST method
Authors: Martin Manon , Chanzy André , Lassabatere Laurent , Legout Arnaud , Pousse Noémie , Ruy Stéphane 
Published: November 2024

Abstract
Key message
The dataset provides hydraulic properties estimated using the Beerkan Estimation of Soil Transfer (BEST) method, on undisturbed and on compacted and rutted French forest soils. It allows a reliable assessment of the effect of traffic on soil permeability. However, hydraulic properties could not be estimated on extremely rutted soils, underscoring the necessity for tailored protocols for these conditions.
The psychodynamics of self-harm
Authors: Gibbons Rachel 
Published: November 2024

SUMMARY
This article examines the complex phenomenon of self-harm, exploring its motivations, theoretical underpinnings and the intricate transference and countertransference reactions that arise in clinical settings. It aims to integrate psychiatric understanding with contemporary theories of the impact of trauma on both the body and the mind, to deepen the knowledge of self-harm and increase the effectiveness of treatment approaches. The article argues for a nuanced view of self-harm and emphasises the need for compassionate, well-informed care. By addressing the psychodynamics of self-harm, the article seeks to improve therapeutic outcomes and foster an empathetic and effective clinical response. Fictitious case studies are used to illustrate these concepts, demonstrating the critical role of early attachment experiences and the challenges faced by healthcare providers in management.
Averaging method for the existence of singular canards in a two-cell inhibitory neural network
Authors: Liu Yaru , Liu Shenquan , Kurths Jürgen 
Published: November 2024

Abstract
Studies of firing rate neuronal competition models, as observed in binocular rivalry, showed that the variation of the stimulus parameters can lead to rich and interesting dynamics. We use the two-cell inhibitory neural network model to address the canards accompanied by the L

s
-typed mixed-mode oscillations (MMOs). Specifically, we prove the existence and asymptotic expression of canards for this two-cell model by the average method. Meanwhile, our simulation indicates that the results are in accordance with the theory. Our solution can provide ideas for determining and selecting weights in model fusion of machine learning.
Technical Note—Leveraging the Degree of Dynamic Substitution in Assortment and Inventory Planning
Authors: Zhang Jingwei , Ma Will , Topaloglu Huseyin 
Published: November 2024

Optimizing Assortment and Inventory Under Stockout-Based Substitution In the realm of retail, a common challenge arises when retailers must decide the set of substitutable products to offer and how much inventory to stock at the beginning of a selling season when customers choose and substitute among the products that are available to them. This problem is challenging, as the demand for each product is shaped by the inventories of all products and the substitution behavior. In this paper, Zhang, Ma, and Topaloglu focus on the stockout-based substitution and develop a novel rounding scheme based on a fluid relaxation. The authors provide a rigorous theoretical analysis of the method, improving earlier results. In particular, for the multinomial logit model, they achieve an optimality gap that does not depend on the number of products. This result has practical implications for online retailers with vast product varieties, ensuring reliable performance, even when both the demand and the number of products are large.
Effect of different running protocols on bone morphology and microarchitecture of the forelimbs in a male Wistar rat model
Authors: Xavier Andy , Bourzac Céline , Bensidhoum Morad , Mura Catherine , Portier Hugues , Pallu Stéphane 
Published: November 2024

Background
It is accepted that the metabolic response of bone tissue depends on the intensity of the mechanical loads, but also on the type and frequency of stress applied to it. Physical exercise such as running involves stresses which, under certain conditions, have been shown to have the best osteogenic effects. However, at high intensity, it can be deleterious for bone tissue. Consequently, there is no clear consensus as to which running modality would have the best osteogenic effects.

Aim
Our objective was to compare the effects of three running modalities on morphological and micro-architectural parameters on forelimb bones.

Methods
Forty male Wistar rats were randomly divided into four groups: high intensity interval training (HIIT), continuous running, combined running ((alternating HIIT and continuous modalities) and sedentary (control). The morphometry, trabecular microarchitecture and cortical porosity of the ulna, radius and humerus were analyzed using micro-tomography.

Results
All three running modalities resulted in bone adaptation, with an increase in the diaphyseal diameter of all three bones. The combined running protocol had positive effects on the trabecular thickness in the distal ulna. The HIIT protocol resulted in an increase in both medio-lateral diameter and cortical bone area over total area (Ct.Ar/Tt.Ar) at the ulnar shaft compared with sedentary condition. Moreover, the HIIT protocol decreased the mean surface area of the medulla (Ma.Ar) according to sedentary condition at the ulnar shaft.

Conclusion
This study has shown that HIIT resulted in a decrease in trabecular bone fraction in favor of cortical bone area at the ulna.