bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Peripheral Vascular Disease With Complications After Total Ankle Arthroplasty
Authors: Conti Matthew S. , Savenkov Oleksandr , Ellis Scott J. 
Published: April 2019

Background: Despite limited evidence, peripheral vascular disease is often cited as a contraindication for total ankle arthroplasty. The purpose of our study was to identify whether peripheral vascular disease in patients undergoing total ankle arthroplasty increased the rate of infection, postoperative irrigation and debridement, or failure of the implant. Methods: The PearlDiver Database was used to identify Medicare patients who underwent a total ankle arthroplasty from 2005 to 2014. These data were then analyzed for postoperative infections within 90 days, subsequent irrigation and debridements, and failure of total ankle arthroplasties. A diagnosis of preoperative peripheral vascular disease only included those patients who had peripheral vascular disease as an ICD-9 diagnosis code and underwent a preoperative lower extremity angiogram prior to total ankle arthroplasty. Medical comorbidities were identified using ICD-9 diagnosis codes. Three multivariable logistic regression models were then developed in order to identify risk factors associated with postoperative infections and failure after total ankle arthroplasty. Results: A total of 10 698 Medicare patients who underwent a primary total ankle arthroplasty were identified. There were 334 patients who had a postoperative infection within 90 days of their total ankle arthroplasty, and 95 of those patients required an irrigation and debridement. Regression analysis demonstrated that patients with peripheral vascular disease had the greatest risk of developing a postoperative infection within 90 days (OR 2.85, P < .01), requiring an irrigation and debridement postoperatively (OR 4.87, P < .001), and having a total ankle arthroplasty failure at any time point postoperatively (OR 2.51, P < .001). Conclusions: Our study suggests that preoperative peripheral vascular disease is a significant risk factor for an acute postoperative infection, postoperative irrigation and debridement, and failure of the implant in Medicare patients undergoing a total ankle arthroplasty. Level of Evidence: Level III, therapeutic.
Myeloid translocation gene CBFA2T3 directs a relapse gene program and determines patient-specific outcomes in AML
Authors: Steinauer Nickolas , Guo Chun , Huang Chunfa , Wong Madeline , Tu Yifan , Freter Carl E. , Zhang Jinsong 
Published: April 2019

Abstract
CBFA2T3 is a master transcriptional coregulator in hematopoiesis. In this study, we report novel functions of CBFA2T3 in acute myeloid leukemia (AML) relapse. CBFA2T3 regulates cell-fate genes to establish gene expression signatures associated with leukemia stem cell (LSC) transformation and relapse. Gene set enrichment analysis showed that CBFA2T3 expression marks LSC signatures in primary AML samples. Analysis of paired primary and relapsed samples showed that acquisition of LSC gene signatures involves cell type–specific activation of CBFA2T3 transcription via the NM_005187 promoter by GCN5. Short hairpin RNA–mediated downregulation of CBFA2T3 arrests G1/S cell cycle progression, diminishes LSC gene signatures, and attenuates in vitro and in vivo proliferation of AML cells. We also found that the RUNX1-RUNX1T1 fusion protein transcriptionally represses NM_005187 to confer t(8;21) AML patients a natural resistance to relapse, whereas lacking a similar repression mechanism renders non–core-binding factor AML patients highly susceptible to relapse. These studies show that 2 related primary AML-associated factors, the expression level of CBFA2T3 and the ability of leukemia cells to repress cell type–specific CBFA2T3 gene transcription, play important roles in patient prognosis, providing a paradigm that differential abilities to repress hematopoietic coregulator gene transcription are correlated with patient-specific outcomes in AML.
Addition of Low-Dose Decitabine to Anti–PD-1 Antibody Camrelizumab in Relapsed/Refractory Classical Hodgkin Lymphoma
Authors: Nie Jing , Wang Chunmeng , Liu Yang , Yang Qingming , Mei Qian , Dong Liang , Li Xiang , Liu Jiejie , Ku Wenjing , Zhang Yan , Chen Meixia , An Xiaojing , Shi Lu , Brock Malcolm V. , Bai Jie , Han Weidong 
Published: April 2019

PURPOSE Anti–programmed death-1 (PD-1) monotherapy induces a high response rate in patients with relapsed/refractory classic Hodgkin lymphoma (cHL), but complete remission (CR) is infrequently observed. As decitabine is known to boost T-cell function, we assessed the safety and efficacy of anti–PD-1 camrelizumab alone versus decitabine-primed camrelizumab in patients with relapsed/refractory cHL. METHODS This two-arm, open-label, phase II study enrolled patients with relapsed/refractory cHL who had received at least two lines of previous therapy. Anti–PD-1 treatment-naïve patients were randomly assigned (1:2) to camrelizumab (200 mg) monotherapy or decitabine (10 mg/d, days 1 to 5) plus camrelizumab (200 mg, day 8) combination therapy every 3 weeks. Patients who were previously treated with anti–PD-1 were assigned combination therapy. Primary end point was CR rate and safety. RESULTS Overall, 86 patients were enrolled and evaluated for response, with a median follow-up of 14.9 months. In anti–PD-1–naïve patients, CR rate was 32% (six of 19 patients) with camrelizumab monotherapy versus 71% (30 of 42 patients) who were administered decitabine plus camrelizumab ( P = .003). At the time of analysis, the response duration rate at 6 months was 76% on camrelizumab monotherapy versus 100% on decitabine plus camrelizumab. For patients who were previously treated with anti–PD-1, 28% achieved CR and 24% partial response after decitabine plus camrelizumab. Ten patients maintained a response at more than 6 months and 81% of responders were estimated to have a response at more than 1 year. For both treatments, the most common adverse events were clinically inconsequential cherry hemangiomas and leukocytopenia that were self-limiting. CONCLUSION CR rate in patients with relapsed/refractory cHL who were clinically naïve to PD-1 blockade was significantly higher with decitabine plus camrelizumab than with camrelizumab alone. Decitabine plus camrelizumab may reverse resistance to PD-1 inhibitors in patients with relapsed/refractory cHL.
Role of septins in microbial infection
Authors: Van Ngo Hoan , Mostowy Serge 
Published: April 2019

ABSTRACT
Septins are widely recognized as a component of the cytoskeleton that is essential for cell division, and new work has shown that septins can recognise cell shape by assembling into filaments on membrane regions that display micrometer-scale curvature (e.g. at the cytokinetic furrow). Moreover, infection biology studies have illuminated important roles for septins in mediating the outcome of host–microbe interactions. In this Review, we discuss a selection of mechanistic insights recently gained from studying three infection paradigms: the rice blast fungus Magnaporthe oryzae, the poxvirus family member vaccinia virus and the Gram-negative bacterium Shigella flexneri. These studies have respectively discovered that higher-order septin assemblies enable fungal invasion into plant cells, entrap viral particles at the plasma membrane and recognize dividing bacterial cells for delivery to lysosomes. Collectively, these insights illustrate how studying septin biology during microbial infection can provide fundamental advances in both cell and infection biology, and suggest new concepts underlying infection control.
Sustainable practices in the coffee supply chain in the cerrado mineiro region, Brazil
Authors: Silva Warley Henrique da , Guarnieri Patrícia , Carvalho José Márcio 
Published: April 2019

The incorporation of sustainable practices in the supply chain management (SCM) has become recurrent in the business environment, resulting from a social reflection on the need to seek new development alternatives. In this context, the objective of this paper is to verify the existence of sustainable practices throughout the supply chain of coffee in the Cerrado Mineiro Region (CMR) and to understand the effects of this adoption regarding Green SCM. This paper focus on the relationship between producers and collective organizations, such as cooperatives and development foundations. To this end, a case study was carried out with the representatives of the supply chain members in CMR, which included coffee producers, cooperatives and a development foundation. It was verified the predominance of practices focused on environmental issues, followed by social and, finally, economic ones. It is also highlighted that the data identified allow us to understand that the development of sustainable strategies can bring positive effects to the agents studied. Considering that these aspects, evidently, improve the relationship of supply chain members, making it more collaborative. The results contribute to the systemic understanding of the way in which sustainability has been incorporated and operationalized in coffe supply chains in CMR.
Trends in Medicare base payment rates for hospital discharges, 2009-2018
Authors: Rapp Zachary , Egeland Ryan , David Frank S. 
Published: April 2019

Background: Under the inpatient prospective payment system (IPPS), Medicare assigns hospital discharges to medical severity-adjusted diagnosis related groups (MS-DRGs), and determines a fixed payment amount for each discharge based on its MS-DRG that is adjusted annually based on providers’ reported costs. Trends in these capitated reimbursement rates may affect the incentive for manufacturers to develop drugs and devices used in inpatient care, as well as the predilection of customers (hospitals) to purchase them. Methods: In this descriptive study, we analyzed the growth of inflation-adjusted MS-DRG base payment rates to acute care hospitals from 2009 to 2018. Results: Inflation-adjusted base reimbursement rates for MS-DRGs in continuous existence from 2009 to 2018 (N=211) had a median best-fit compound annual growth rate (CAGR) of -0.26%. Medical MS-DRGs exhibited a more negative median best-fit CAGR than surgical ones. Among surgical MS-DRGs, those related to musculoskeletal diagnoses had a larger median best-fit CAGR that was statistically significant compared with those associated with digestive or infectious disease diagnoses. Conclusions: The majority of MS-DRG base payment rates for inpatient discharges have failed to keep pace with inflation, and this negative growth is more pronounced in certain clinical areas. The relationship between these reimbursement trends and decision-making by manufacturers and hospitals warrants further study.
Early repair of trauma-related full-thickness rotator cuff tears does not eliminate the problem of healing failure
Authors: Aagaard K. E. , Lunsjö K. , Frobell R. 
Published: April 2019

AimsFailure of healing is a well-known problem after repair of the rotator cuff. This study aimed to investigate if early repair of trauma-related full-thickness rotator cuff tears (FTRCTs) could prevent this failure.Patients and MethodsIn this prospective trial, 62 consecutive patients (14 women (23%), 48 men (77%); median age 61 years (interquartile range (IQR) 54 to 65)) with trauma-related FTRCT underwent arthroscopic single-row repair within six weeks of trauma. Tendon integrity was assessed one year after surgery using the Sugaya score on MR images. Patients were followed up with Western Ontario Rotator Cuff (WORC) index, EuroQol visual analogue scale (EQ VAS), and the Constant–Murley score (CS) two years after repair.ResultsA total of 57 patients (92%) had MR images available at one year; 59 patients (95%) had CS (one year), WORC (two years), and EQ VAS scores (two years). Intact repair was found on MRI in 36 patients (63%); 13 patients (23%) displayed healing failure of at least one repaired tendon and eight patients (14%) displayed total healing failure. Median WORC index and relative CS improved from 30.8 points (IQR 20.1 to 38.6) at baseline to 85.0 points (IQR 60.6 to 95.7) at two years and 26.5 points (IQR 21.2 to 37.4) to 83.2 points (IQR 71.9 to 97.5) at one year, respectively. The relative CS at one year was significantly better among those with intact repairs compared with those with healing failure (91.6 vs 78.1 points; p = 0.031).ConclusionAlthough early repair of trauma-related FTRCT improved patient relevant outcomes over two years for the entire cohort, only two out of three repaired rotator cuffs displayed intact structural integrity on MRI after one year. Consequently, early repair did not seem to prevent healing failure after trauma-related FTRCT. Cite this article: Bone Joint J 2019;101-B:603–609.
Production Planning and Control as Routing in Manufacturing Networks
Authors: Bach Terje , Jæger Bjørn , Hoff Arild 
Published: April 2019

In this paper, we explore the use of network routing for production planning and control in manufacturing of complex industrial products. Such a product is the result of a joint effort of many manufacturing companies; each considered a collection of work centre nodes connected by transportation links forming a company-wide manufacturing network. Each company is, in turn considered a manufacturing node connected to other manufacturers by transportation links forming a distributed manufacturing network that produces the final product. We model the manufacturing network as a distribution network where the incoming and outgoing inventories of products are distinct nodes in addition to the work centre nodes. Production planning and control are done by minimizing the cost of handling all products in all work centre nodes. This formulation provides a scalable and flexible production planning and control scheme adhering to the networked structure of manufacturing of complex products. We apply the model to a company-wide manufacturing network as a first approach. A case study using the model demonstrates production planning using network routing at a manufacturer of ship propulsion engines.
WECIA Graph: Visualization of Classification Performance Dependency on Grayscale Conversion Setting
Authors: Skrabanek Pavel , Yayilgan Sule Yildirim 
Published: April 2019

Grayscale conversion is a popular operation performed within image pre-processing of many computer vision systems, including systems aimed at generic object categorization. The grayscale conversion is a lossy operation. As such, it can signicantly in uence performance of the systems. For generic object categorization tasks, a weighted means grayscale conversion proved to be appropriate. It allows full use of the grayscaleconversion potential due to weighting coefficients introduced by this conversion method. To reach a desired performance of an object categorization system, the weighting coefficients must be optimally setup. We demonstrate that a search for an optimal setting of the system must be carried out in a cooperation with an expert. To simplify the expert involvement in the optimization process, we propose a WEighting Coefficients Impact Assessment (WECIA) graph. The WECIA graph displays dependence of classication performance on setting of the weighting coefficients for one particular setting of remaining adjustable parameters. We point out a fact that an expert analysis of the dependence using the WECIA graph allows identication of settings leading to undesirable performance of an assessed system.
Using Artificial Intelligence to Determine the Type of Rotary Machine Fault
Authors: Zuth Daniel , Marada Tomas 
Published: April 2019

The article deals with the possibility of using machine learning in vibrodiagnostics to determine the type of fault of rotating machine. The data source is real measured data from the vibrodiagnostic model. This model allows simulation of some types of faults. The data is then processed and reduced for the use of the Matlab Classication learner app, which creates a model for recognizing faults. The model is ultimately tested on new samples of data. The aim of the article is to verify the ability to recognize similarly rotary machine faults from real measurements in the time domain.
Differential Evolution and Deterministic Chaotic Series: A Detailed Study
Authors: Senkerik Roman , Viktorin Adam , Zelinka Ivan , Pluhacek Michal , Kadavy Tomas , Kominkova Oplatkova Zuzana , Bhateja Vikrant , Satapathy Suresh Chandra 
Published: April 2019

This research represents a detailed insight into the modern and popular hybridization of deterministic chaotic dynamics and evolutionary computation. It is aimed at the influence of chaotic sequences on the performance of four selected Differential Evolution (DE) variants. The variants of interest were: original DE/Rand/1/ and DE/Best/1/ mutation schemes, simple parameter adaptive jDE, and the recent state of the art version SHADE. Experiments are focused on the extensive investigation of the different randomization schemes for the selection of individuals in DE algorithm driven by the nine different two-dimensional discrete deterministic chaotic systems, as the chaotic pseudorandom number generators. The performances of DE variants and their chaotic/non-chaotic versions are recorded in the one-dimensional settings of 10D and 15 test functions from the CEC 2015 benchmark, further statistically analyzed.
Particle Swarm Optimization with Distance Based Repulsivity
Authors: Pluhacek Michal , Zelinka Ivan , Senkerik Roman , Viktorin Adam , Kadavy Tomas 
Published: April 2019

In this study, we propose a repulsive mechanism for the Particle Swarm Optimization algorithm that improves its performance on multi-modal problems. The repulsive mechanism is further extended with a distance-based modification. The results are presented and tested for statistical significance. We discuss the observations and propose further directions for the research.
Diagnosis of Hemoglobinopathy and β-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood
Authors: He Lidong , Rockwood Alan L , Agarwal Archana M , Anderson Lissa C , Weisbrod Chad R , Hendrickson Christopher L , Marshall Alan G 
Published: April 2019

Abstract

BACKGROUND
Hemoglobinopathies and thalassemias are the most common genetically determined disorders. Current screening methods include cation-exchange HPLC and electrophoresis, the results of which can be ambiguous because of limited resolving power. Subsequently, laborious genetic testing is required for confirmation.

METHODS
We performed a top-down tandem mass spectrometry (MS/MS) approach with a fast data acquisition (3 min), ultrahigh mass accuracy, and extensive residue cleavage by use of positive electrospray ionization 21 Tesla Fourier transform ion cyclotron resonance–tandem mass spectrometry (21 T FT-ICR MS/MS) for hemoglobin (Hb) variant de novo sequencing and β-thalassemia diagnosis.

RESULTS
We correctly identified all Hb variants in blind analysis of 18 samples, including the first characterization of homozygous Hb Himeji variant. In addition, an Hb heterozygous variant with isotopologue mass spacing as small as 0.0194 Da (Hb AD) was resolved in both precursor ion mass spectrum (MS1) and product ion mass spectrum (MS2). In blind analysis, we also observed that the abundance ratio between intact δ and β subunits (δ/β) or the abundance ratio between intact δ and α subunits (δ/α) could serve to diagnose β-thalassemia trait caused by a mutation in 1 HBB gene.

CONCLUSIONS
We found that 21 T FT-ICR MS/MS provides a benchmark for top-down MS/MS analysis of blood Hb. The present method has the potential to be translated to lower resolving power mass spectrometers (lower field FT-ICR mass spectrometry and Orbitrap) for Hb variant analysis (by MS1 and MS2) and β-thalassemia diagnosis (MS1).
Health Care Providers Discussions of Tobacco Use, Advice to Quit and Patient Satisfaction at College Health Centres
Authors: Burke Michael V. 
Published: April 2019

AbstractThe prevalence of cigarette smoking among young people is a cause for concern. College health care providers (HCPs) can provide evidence-based interventions but frequently do not, in part, because of concerns that tobacco interventions might alienate their young patients. Six hundred and eighty-four college student patients were interviewed as they exited a college health centre. The patients were asked about smoking status, about discussions with their provider regarding tobacco and to rate their satisfaction with the visit. Of the students who smoked, 48.6% reported the HCP discussed tobacco use and 38.6% reported that the HCP provided advice to quit. Mean ranked satisfaction was significantly higher among students who received tobacco discussions and/or advice to quit. This study should encourage college providers to intervene with smoking college students without fear that this will alienate patients.
Bilingual children as “laboratories” for studying contact outcomes: Development of perfective aspect
Authors: Szeto Pui Yiu , Matthews Stephen , Yip Virginia 
Published: April 2019

AbstractThis paper examines the close parallels between the contact phenomena in Cantonese-English bilingual children and Southeast Asian creoles, especially in the domain of perfective aspect marking. ‘Already’ is a cross-linguistically common lexical source of perfective aspect markers given its conceptual link with the sense of perfectivity. In contact scenarios involving a European lexifier and Southeast Asian substrates, the development of ‘already’ into a perfective marker is further triggered by the incompatibility between the verbal morphology of the former and the isolating typology of the latter. Adopting an ecological approach to language transmission and creole genesis we discuss how the transient grammaticalization phenomena in the bilingual children can be compared to decreolization, and how the study of bilingual acquisition can contribute to contact linguistics. Despite the prevalence of unpredictable factors in contact scenarios, we argue that bilingual children can still serve as powerful “laboratories” for studying contact outcomes at the communal level.
Intersubjectivity and engagement in Ku Waru
Authors: Rumsey Alan 
Published: April 2019

Abstract
Following Evans et al. (2018a, 2018b), I use “engagement” to refer to grammatical encoding of the relative accessibility of an entity or state of affairs to the speaker and addressee. I refer to what is thereby encoded as the “engagement function”. How neatly does that function map on to grammatical categories of particular languages? Here I address that question with respect to the Papuan language Ku Waru, focusing on spatial and epistemic demonstratives, and definiteness and indefinite marking. I show that forms within each of those word/morpheme classes do serve engagement functions, but in cross-cutting and partial ways. I show how the engagement function is also achieved through poetic parallelism, prosody, gaze direction and other aspects of bodily comportment. In the examples considered, the engagement function is realised through interaction between those extra-linguistic features and the grammatical ones. The main thing that is added by grammatical engagement marking is an explicit signalling of the intersubjective accord that has been achieved on other bases. I hypothesize that that is true of engagement overall, and conclude by suggesting some ways to test that hypothesis and to advance the understanding of engagement more generally.