bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing Extrinsic Dissipation to Enhance the Toughness of Composites and Composite Joints: A State‐of‐the‐Art Review of Recent Advances
Authors: Lubineau Gilles , Alfano Marco , Tao Ran , Wagih Ahmed , Yudhanto Arief , Li Xiaole , Almuhammadi Khaled , Hashem Mjed , Hu Ping , Mahmoud Hassan A. , Oz Fatih 
Published: November 2024

AbstractInterfaces play a critical role in modern structures, where integrating multiple materials and components is essential to achieve specific functions. Enhancing the mechanical performance of these interfaces, particularly their resistance to delamination, is essential to enable extremely lightweight designs and improve energy efficiency. Improving toughness (or increasing energy dissipation during delamination) has traditionally involved modifying materials to navigate the well‐known strength‐toughness trade‐off. However, a more effective strategy involves promoting non‐local or extrinsic energy dissipation. This approach encompasses complex degradation phenomena that extend beyond the crack tip, such as long‐range bridging, crack fragmentation, and ligament formation. This work explores this innovative strategy within the arena of laminated structures, with a particular focus on fiber‐reinforced polymers. This review highlights the substantial potential for improvement by presenting various strategies, from basic principles to proof‐of‐concept applications. This approach represents a significant design direction for integrating materials and structures, especially relevant in the emerging era of additive manufacturing. However, it also comes with new challenges in predictive modeling of such mechanisms at the structural scale, and here the latest development in this direction is highlighted. Through this perspective, greater durability and performance in advanced structural applications can be achieved.
3D Nano Hafnium‐Based Ferroelectric Memory Vertical Array for High‐Density and High‐Reliability Logic‐In‐Memory Application
Authors: Yu Jiajie , Wang Tianyu , Lu Chen , Li Zhenhai , Xu Kangli , Liu Yongkai , Song Yifan , Meng Jialin , Zhu Hao , Sun Qingqing , Zhang David Wei , Chen Lin 
Published: November 2024

AbstractA new type of ferroelectric memory device with high reliability and complementary metal‐oxide‐semiconductor (CMOS) compatibility characteristics is an important condition for achieving integrated memory and computing chips. Here, 3D stacked ferroelectric memory devices based on ferroelectric materials of HfO2 are fabricated. The device exhibits high speed (50 ns), low read voltage (0.5 V), and great reliability with no substantial degradation after 1010 cycles and a 10‐years data retention at 85 °C. The IMP and NAND logic are achieved with stable memory window (>200 mV) across the vertical devices’ interconnection. On this basis, combining with the traditional CMOS logic device, multiple combination logic functions containing NOT, AND, and NOR are achieved by simulation. The collaboration of devices in the vertical direction providing the possibility of combining multi‐bit logic in memory functions and paves the way for the implementation of high‐density, high‐reliability, and low‐energy consumption computing‐in‐memory chips compatible with the CMOS technology.
Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot
Authors: Witzig Thomas E. , Taylor William R. , Mahoney Douglas W. , Bamlet William R. , Foote Patrick H. , Burger Kelli N. , Doering Karen A. , Devens Mary E. , Arndt Jacquelyn R. , O'Connell Maria C. , Berger Calise K. , Novak Anne J. , Cerhan James R. , Hennek Jacquelyn , Katerov Slava , Allawi Hatim T. , Jevremovic Dragan , Dao Linda N. , Graham Rondell P. , Kisiel John B. 
Published: November 2024

ABSTRACTLymphoma is one of the leading causes of cancer and cancer deaths and yet has not been amenable to population screening. The role of methylated DNA markers (MDMs) in the detection of lymphoma has not been extensively studied. We aimed to discover, validate, and test tissue–derived MDMs of lymphoma in archival plasma specimens. Reduced representation bisulfite sequencing (RRBS) was performed on a discovery set of frozen tissues. MDMs identified were converted to methylation–specific PCR assays and validated on independent formalin–fixed, paraffin‐embedded (FFPE) tissues. Target enrichment long–probe quantitative‐amplified signal (TELQAS) assays were developed and assayed in plasma–extracted, bisulfite‐converted DNA from independent treatment‐naïve lymphoma patients and healthy controls. Prediction of cancer status was modeled using random forest model with in silico cross‐validation. After discovery and validation in tissue, 16 TELQAS assays (ZNF503, VWA5B1, HOXA9, GABRG3, ITGA5, MAX.chr17.7190, BNC1, CDK20, MAX.chr4.4069, TPBG, DNAH14, SYT6, CACNG8, FAM110B, ADRA1D, and NRN1) were selected for testing in plasma. These detected 78% (95% CI, 74%–82%) of lymphoma cases at 90% specificity. Excluding marginal zone and T‐cell lymphomas, sensitivity increased to 84% (80%–88%). MDMs in plasma show promise to detect lymphoma and are candidates for inclusion in multi‐cancer detection studies.
Centiloid recommendations for clinical context‐of‐use from the AMYPAD consortium
Authors: Collij Lyduine E. , Bollack Ariane , La Joie Renaud , Shekari Mahnaz , Bullich Santiago , Roé‐Vellvé Núria , Koglin Norman , Jovalekic Aleksandar , Garciá David Valléz , Drzezga Alexander , Garibotto Valentina , Stephens Andrew W. , Battle Mark , Buckley Christopher , Barkhof Frederik , Farrar Gill , Gispert Juan Domingo ,   AMYPAD consortium
Published: November 2024

AbstractAmyloid‐PET quantification through the tracer‐independent Centiloid (CL) scale has emerged as an essential tool for the accurate measurement of amyloid‐β (Aβ) pathology in Alzheimer's disease (AD) patients. The AMYPAD consortium set out to integrate existing literature and recent work from the consortium to provide clinical context‐of‐use recommendations for the CL scale. Compared to histopathology, visual reads, and cerebrospinal fluid, CL quantification accurately reflects the amount of AD pathology. With high certainty, a CL value below 10 excludes the presence of Aβ pathology, while a value above 30 corresponds well with pathological amounts. Values falling in between these two cutoffs (“intermediate range”) are related to an increased risk of disease progression. Together, CL quantification is a valuable adjunct to visual assessments of amyloid‐PET images. An abnormal amyloid biomarker assessment is a key criterion to determine eligibility for anti‐amyloid disease‐modifying therapies, and amyloid‐PET quantification can add further value by precisely monitoring amyloid clearance, and hence guiding patient management decisions.Highlights
Centiloid (CL) quantification robustly reflects of the amount of Aβ pathology.
CL < 10/CL > 30 reflects Aβ‐negativity/positivity thresholds with high certainty.
CL quantification is a valuable adjunct to visual assessments of amyloid‐PET.
CL quantification can support trial design and treatment management.
CL quantification could support the identification of early or emerging Aβ pathology.
Hochleistungsaerogelbeton – Biegetragverhalten mit Bewehrung aus GFK
Authors: Heidrich Till , Welsch Torsten , Schnellenbach‐Held Martina 
Published: November 2024

AbstractHochleistungsaerogelbeton (High Performance Aerogel Concrete, HPAC) ist ein neuartiger, auf einer Einbettung von Leichtzuschlägen aus Silica‐Aerogelen in HPC‐Matrizen basierender Konstruktionsleichtbeton. Für die Herstellung biegebeanspruchter HPAC‐Bauteile ist, wie bei Normal‐ und anderen Konstruktionsleichtbetonen auch, die Anordnung einer inneren Bewehrung auf der Biegezugseite erforderlich. Aus bauphysikalischen Erwägungen und aus Gründen der Dauerhaftigkeit sollte hierfür vorzugweise Bewehrung aus faserverstärkten Kunststoffen (FVK), bspw. GFK‐Bewehrung, zum Einsatz kommen. Um das Biegetragverhalten FVK‐bewehrter HPAC‐Bauteile zu untersuchen, wurden 16 Vier‐Punkt‐Biegeversuche an HPAC‐Balken unterschiedlicher Festigkeiten und mit unterschiedlichen Bewehrungsgraden durchgeführt. Zum besseren Verständnis der Versagensmechanismen wurden physikalisch nichtlineare Finite‐Elemente‐Simulationen durchgeführt, die anhand der Versuchsergebnisse validiert wurden. Aus den Resultaten der experimentellen und numerischen Untersuchungen wurde ein Modell zur Biegebemessung FVK‐bewehrter HPAC‐Bauteile abgeleitet. Nachfolgend werden diese Arbeiten zum Biegetragverhalten von HPAC‐Bauteilen mit GFK‐Bewehrung vorgestellt.
Optimization of Extraction Conditions of Phenolic Compounds and Antioxidant Activity From Myrtle (Myrtus communis L.) Fruit
Authors: Taibi Abdeslem , Mokrani Abderrahmane , Kadi Ahcene , Bouherour Razika , Guermi Nour El Yakine , Teffane Mohand , Arroul Younes , Richard Tristan 
Published: November 2024

ABSTRACTThe extraction of polyphenols from myrtle (Myrtus communis L.) fruits using a conventional solid‐liquid extraction was optimized using a single‐factor experiment approach. The influence of several parameters such as type of solvent (50% acetone, 50% methanol, 50% ethanol, and water), solvent concentration (30‐100%; v/v), solvent acidity (0‐0,1 N), temperature (20°C–40°C) and time (30–360 min) on the yield extraction of total phenolic content (TPC), total flavonoid content (TFC), total proanthocyanidin content (TPAC), and on the antioxidant activity: DPPH‐radical scavenging activity (DPPH‐RSA), ABTS‐radical scavenging activity (ABTS‐RSA) and ferric reducing power (FRP) was studied. The results showed that 50% acetone, 40°C, and 180 min were the best conditions for extracting TPC (87 mg GAE/g DW), TFC (12 mg QE/g DW), and TPAC (76 mg CE/g DW). Myrtle berries extracted with these conditions also exhibited the strongest antioxidant activity: DPPH‐RSA (143 mg TE/g DW), ABTS‐RSA (164 mg TE/g DW), and FRP (69 mg AAE/g DW). Pearson correlation coefficients showed good positive correlations between TPC, TFC, and TPAC and antioxidant activities (DPPH‐RSA, ABTS‐RSA, and FRP), mainly under the effect of solvent type (0.93 < r < 0.99) and solvent concentration (0.91 < r < 0.99).
Siloxyflavylium Triflates as Organic Photocatalysts
Authors: Alanthadka Anitha , Carleu Lillian , Vitarbo August , Laybourn Kalen , Grimm Ronald L. , Mattson Anita E. 
Published: November 2024

AbstractPhotocatalysis is a promising tool for complex molecule construction. Inspired by the potential of photocatalysis, the investigations herein describe the development of siloxyflavium triflates as a new family of organic photocatalysts for synthetic chemistry. In this report, the application of siloxyflavium triflate photocatalysis is demonstrated in the α‐C‐H activation of ethers in the presence of chromenones to generate valuable, biologically relevant C(sp3)‐C(sp3) linkages. The scope of the bond‐forming event is demonstrated with 20 substrates.
Is ASCT2 a Suitable Vector for the Selective Delivery of Anticancer Drugs? Modification of Glutamine at Either the Carboxylate or the Side Chain Hinders Binding and Transport
Authors: M Vinitha , Mohammed Adnan Ibrahim , Briot Chelsea , Ryan Renae M. , Hambley Trevor W. 
Published: November 2024

AbstractThe Alanine, Serine, and Cysteine Transporter 2 (ASCT2) transports glutamine into cells and is upregulated in many cancers. Attachment to glutamine to enable ASCT2 to transport anticancer agents into cells has been proposed, but the impact of such modifications is a critical determinant of the potential of this strategy. Transport via ASCT2 of two glutamine analogues modified in ways that reflect possible mechanisms for attaching anticancer agents was studied. The aim was to determine if the modification of glutamine interferes with its transport via ASCT2 and thereby establish whether the conjugation of drugs to glutamine can facilitate the accumulation of anticancer drugs in cancer cells. L‐theanine and a glutamine derivative modified at the carboxylate (7) were applied to Xenopus laevis oocytes expressing ASCT2. Two‐electrode voltage clamp electrophysiology was used to measure substrate‐elicited currents over a range of membrane potentials. Compound 7 was identified as neither a substrate nor an inhibitor while L‐theanine was identified as an inhibitor of ASCT2. Thus, modification of glutamine in these ways prevents it from acting as a substrate and suggests that ASCT2 may not be a suitable target for delivery of anticancer drugs attached via either the carboxylate or side chain positions.
Commercial Silica Materials Functionalized with a Versatile Organocatalyst for the Catalysis Of Acylation Reactions in Liquid Media
Authors: Brand Raoul D. , Maass Mareike , Grebenyuk Anatoliy G. , Golub Alexander A. , Smarsly Bernd M. 
Published: November 2024

AbstractSilica materials, natural and synthetic variants, represent a promising material for the application in heterogeneous organocatalysis due to their readily modifiable surface and chemical inertness. To achieve high catalyst loadings, usually, porous carriers with high surface areas are used, such as silica monoliths or spherical particles for packed bed reactors. While these commercial materials were shown to be efficient supports, their synthesis is elaborate, and thus less complex and cheaper alternatives are of interest, especially considering scaling up for potential applications. In this work, two commercial silica materials functionalized with the organocatalyst 4‐(dimethylamino)pyridine (DMAP) were used in catalytic acylation reactions: a mesoporous silica gel (Siliabond‐DMAP) and non‐porous silica nanoparticles (Ludox). While both were successfully used in the acylation of phenylethanol, the latter required significantly longer reaction times, presumably due to the lack of mesopores and the associated spatial confinement, as well as agglomeration that limits the active amount of catalyst. Furthermore, we find that the influence of the linker molecule is negligible, since for two different linker motifs the reaction yields and activation energy remain largely similar. Lastly, as main result the commercial material Siliabond‐DMAP, despite the non‐uniform particles, were employed in a flow setup, thus demonstrating the potential as support material for application in heterogeneous organocatalysis.
Women and leadership in non‐listed private companies in an emerging country: An analysis of barriers and facilitators
Authors: Islam Md Asadul , Hack‐Polay Dieu , Rahman Mahfuzur , Fijałkowska Justyna , Dal Mas Francesca 
Published: November 2024

AbstractThis study explores women's barriers to accessing leadership positions within non‐listed private companies in Bangladesh, drawing on the Gendered Organization Theory (GOT) as a conceptual framework. This research seeks some possible solutions to overcome these barriers. The study adopts a two‐wave qualitative methodology: semi‐structured interviews with 16 women professionals and subsequent focus‐group discussions to explore solutions. Results reveal that women face significant barriers, such as long working hours, gender pay gaps, unclear responsibilities, biased promotion processes, lack of training, and sexual harassment. These barriers are conceptualized in terms of implicit and explicit gender biases. Research participants emphasized individual efforts like self‐determination, upskilling, job switching, technology leveraging, and family support as key factors in overcoming these obstacles. The study underscores the need for organizational and governmental interventions to promote female leadership and gender equity in non‐listed companies in developing countries.
Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry
Authors: Mosburg Mary , Li Yajing , Helmes Emily , Falt Tara D. , Trott Josephine F. , Solomon Gina , Hovey Russell C. , Moeller Benjamin C. 
Published: November 2024

ABSTRACTHormonal growth promotants (HGPs) are a class of pharmaceutical agents commonly administered to cattle in the United States to improve growth rates of the animal, alter behavior, or to improve the desired characteristics of retail cuts of meat. There is a concern that low residual concentrations of HGPs may remain in tissue after slaughter, and consumption of tissues containing these compounds may increase the risk of adverse health outcomes, including cancer. Sensitive and selective methods are necessary to assess exposure of HGPs by populations that consume meat products from animals that may have been administered HGPs. A liquid chromatography–tandem mass spectrometry method was developed and validated to detect the low‐level presence of HGPs including estradiol, testosterone, estradiol benzoate, melengestrol, melengestrol acetate, progesterone, testosterone propionate, trenbolone, trenbolone acetate, and α‐zearalanol in retail cuts of meat following a liquid–liquid extraction using a high pH solution with 30–50× less mass of meat required as compared to similar approaches. Good chromatographic performance and sensitivity was achieved utilizing ammonium fluoride as a mobile phase additive without the need for derivatization. Validation parameters including accuracy, precision, recovery, matrix effects, limits of detection, limits of quantitation, linear range, and stability were determined. The limits of detection ranged from 0.1 to 1.0 ng/g, depending on the compound, with adequate accuracy and precision without the need for extensive sample preparation approaches.
Symbiont Acquisition Strategies in Post‐Settlement Stages of Two Co‐Occurring Deep‐Sea Rimicaris Shrimp
Authors: Guéganton Marion , Methou Pierre , Aubé Johanne , Noël Cyril , Rouxel Ouafae , Cueff‐Gauchard Valérie , Gayet Nicolas , Durand Lucile , Pradillon Florence , Cambon‐Bonavita Marie‐Anne 
Published: November 2024

ABSTRACTAt deep‐sea hydrothermal vents, deprived of light, most living communities are fueled by chemosynthetic microorganisms. These can form symbiotic associations with metazoan hosts, which are then called holobionts. Among these, two endemic co‐occurring shrimp of the Mid‐Atlantic Ridge (MAR), Rimicaris exoculata and Rimicaris chacei are colonized by dense and diversified chemosynthetic symbiotic communities in their cephalothoracic cavity and their digestive system. Although both shrimp harbor similar communities, they exhibit widely different population densities, distribution patterns at small scale and diet, as well as differences in post‐settlement morphological modifications leading to the adult stage. These contrasting biological traits may be linked to their symbiotic development success. Consequently, key questions related to the acquisition of the symbiotic communities and the development of the three symbiotic organs are still open. Here we examined symbiotic development in juveniles of R. exoculata and R. chacei from TAG and Snake Pit using 16S metabarcoding to identify which symbiotic lineages are present at each juvenile stage. In addition, we highlighted the abundance and distribution of microorganisms at each stage using Fluorescence in situ Hybridization (FISH) and Scanning Electron Microscopy (SEM). For the first time, Candidatus Microvillispirillaceae family with Candidatus Rimicarispirillum spp. (midgut tube), Candidatus Foregutplasma rimicarensis and Candidatus BG2‐rimicarensis (foregut) were identified in late juvenile stages. However, these lineages were absent in early juvenile stages, which coincides for the midgut tube with our observations of an immature tissue, devoid of microvilli. Conversely, symbiotic lineages from the cephalothoracic cavity were present from the earliest juvenile stages of both species and their overall diversities were similar to those of adults. These results suggest different symbiont acquisition dynamics between the cephalothoracic cavity and the digestive system, which may also involve distinct transmission mechanisms.
Effects of sacubitril/valsartan according to background beta‐blocker therapy in patients with heart failure and reduced ejection fraction: Insights from PARADIGM‐HF
Authors: Gupta Sharmistha Datta , Butt Jawad H. , McMurray Eoghan G.M. , Talebi Atefeh , Matsumoto Shingo , Rizkala Adel R. , Henderson Alasdair D. , Desai Akshay S. , Lefkowitz Martin , Packer Milton , Rouleau Jean L. , Solomon Scott D. , Swedberg Karl , Zile Michael R. , Jhund Pardeep S. , McMurray John J.V. ,   for the PARADIGM‐HF Investigators and Committees
Published: November 2024

AimsBeta‐blockers may inhibit neprilysin activity and conversely, neprilysin inhibition may have a sympatho‐inhibitory action. Consequently, sacubitril/valsartan may have a greater effect in patients not receiving a beta‐blocker compared to those treated with a beta‐blocker.Methods and resultsWe examined the effect of sacubitril/valsartan compared to enalapril on outcomes according to background beta‐blocker treatment in the 8399 patients with heart failure with reduced ejection fraction enrolled in PARADIGM‐HF. The primary outcome was time to first heart failure hospitalization or cardiovascular death. Compared to the 7811 patients taking a beta‐blocker, the 588 patients not receiving a beta‐blocker were older, more frequently female, but had a similar mean left ventricular ejection fraction and New York Heart Association class distribution, with little difference in N‐terminal pro‐B‐type natriuretic peptide. Patients not taking beta‐blockers had a higher rate of the primary endpoint than those taking beta‐blockers. The benefit of sacubitril/valsartan on the primary endpoint was evident in both the no beta‐blocker subgroup (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.45–0.82) and the beta‐blocker subgroup (HR 0.82, 95% CI 0.75–0.90; p‐interaction = 0.06). The respective HRs for cardiovascular death were 0.47 (95% CI 0.32–0.69) versus 0.84 (95% CI 0.75–0.95; p‐interaction <0.01) and for HF hospitalization 0.76 (95% CI 0.51–1.12) versus 0.80 (95% CI 0.71–0.90; p‐interaction = 0.73). For all‐cause death, the HR in the no beta‐blocker group was 0.50 (95% CI 0.36–0.71) compared to 0.89 (95% CI 0.80–0.99) in the beta‐blocker group (p‐interaction <0.01). Safety outcomes related to sacubitril/valsartan versus enalapril did not differ according to background beta‐blocker use.ConclusionSacubitril/valsartan may be more effective than enalapril in reducing the risk of death in patients not treated with a beta‐blocker compared to those treated with a beta‐blocker, but is effective regardless of beta‐blocker use.Clinical Trial Registration: ClinicalTrials.gov NCT01035255.