bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain
Authors: Kute Preeti M , Pauzin Francois P , Labun Kornel , Bramham Clive R , Valen Eivind 
Published: November 2024

AbstractProtein synthesis in neurons is highly compartmentalised and regulated, with key roles for translation initiation and elongation factors. The most widely used transcriptome-wide method for measuring translation, ribosome profiling, characterises the elongation phase of translation but does not provide insight into the initiation phase with scanning of the small ribosomal subunit (SSU). Here, we adapted and optimised ribosome complex profiling (RCP-seq) for brain tissue, that captures SSUs and allows analysis of translation initiation dynamics in the adult murine dentate gyrus (DG) region of the hippocampus. We show an accumulation of SSUs upstream of the start codon specifically enriched on synaptically localised RNAs and extensive translation of 5’ upstream open reading frames (uORFs), suggesting regulation both during scanning and transition to the elongation phase. We further demonstrate that neuron-specific transcripts are more expressed, scanned, and translated than glia-specific transcripts. Of the neuronal mRNAs, monosome-preferring mRNAs exhibited reduced scanning and elongation relative to polysome-preferring transcripts implying reduced recruitment of ribosomes. In sum, RCP-seq elucidates translation initiation dynamics in the mammalian brain and uncovers cell-type-and transcript-specific regulation.
Rapid fluctuations in histamine associated with intake of nutritive and non-nutritive solutions
Authors: Volcko KL , Gresch A , Benowitz B , Taghipourbibalan H , Visser M , Stuber GD , Gordon-Fennell AG , Patriarchi T , McCutcheon JE 
Published: November 2024

AbstractThe neurotransmitter histamine is involved in control of food intake, yet its dynamics during individual feeding episodes remain unexplored. Therefore, we used the novel genetically-encoded histamine sensor, HisLightG, combined with fiber photometry to measure histamine release in two hypothalamic regions critical in the food-suppressive effects of histamine, the paraventricular nucleus of the hypothalamus (PVH), and the ventromedial hypothalamus (VMH). Male mice were tested under different conditions to assess whether hunger, time of day, or the caloric content of the solution they were given affected histamine fluctuations. We found that histamine levels changed rapidly in response to eating, with reductions in histamine release occurring towards the end of licking bouts. These histamine fluctuations were independent of the experimental conditions. Notable regional differences were identified, however, such that in the PVH histamine rebounded to baseline levels, whereas in the VMH histamine remained lower than baseline for at least 10 seconds after licking ceased. In a separate cohort of male and female mice, enhancing histamine tone via administration of a histamine precursor (L-histidine) reduced the number of licks across multiple sucrose concentrations. Together, these findings indicate that histaminergic activity is modulated rapidly during ingestive episodes, and that understanding these release patterns may give insight into histamine’s role in appetite suppression.Significance statementThe findings from these experiments are important because, for the first time histamine has been recorded using a novel sensor, HisLightG, via fiber photometry during food intake. We now know that the neurotransmitter fluctuates on a timescale of seconds and is closely linked to licking behavior. This, combined with the multispout data demonstrating a pronounced effect of histamine precursor on licking, set the stage for future experiments to elucidate precisely what role histamine in particular nuclei has in eating behavior.
Development and validation of the leader–member exchange scale in the Indian context
Authors: Srivastava Urmila Rani , Mohaley Shefali , Jaiswal Aishwarya , Singh Meena 
Published: November 2024

PurposeThe primary objective of the present study was to develop an appropriate scale for evaluating LMX by investigating how individuals personally perceive and encounter distinct relationships (both high quality and low quality) with their supervisors, with a specific focus on the Indian context.Design/methodology/approachThe scale was administered on a sample of 290 middle-level managers from two large manufacturing organizations located in North India.FindingsThe factors identified as important for the construct of leader-member exchange were affect, loyalty, and contribution.Research limitations/implicationsThe internal consistency reliability of the LMX contribution dimension is very low. Future researchers should add a few additional items to increase the reliability of the contribution scale of LMX scale so that it fulfills adequate criteria of reliability. Further, the supervisor–subordinate relationship from both supervisor and subordinate perspectives should also be examined.Practical implicationsThis study has made significant advancements in the field of LMX. The findings will also be utilized by the authorities of the organization in focusing future training for its managers.Social implicationsThe findings of this research will help not only advancement in the field of LMX but will also help the manager using LMX to influence subordinates to have better knowledge on which factors to focus on to get better results.Originality/valueOverall, the results of the current study provide evidence for the sound reliability and validity of the leader-member exchange scale with employees of Indian manufacturing organizations, supporting its use with these populations. Further, this scale is suitable not only in Indian culture but also in the Western cultural context, as the results corroborate the findings of Western scholars, indicating a fair level of cross-cultural validity. However, future research should also address the cross-validation of the factor structure of LMX on other samples and occupations.
Leveraging players' goal-setting and cognitive gaming elements to create flow
Authors: Pham Thi Tuan Linh , Huang Guan-Ling , Huang Tzu-Ling , Liao Gen-Yih , Cheng T.C.E. , Teng Ching-I 
Published: November 2024

PurposeOnline games are widely adopted electronic applications that facilitate flow experiences, which is a highly enjoyable experience for players, thus motivating further engagement in online gameplay. During gameplay, players set gaming goals, and they must make cognitive efforts to achieve these goals. However, we do not know how goal-setting and cognitive gaming elements (game complexity and game familiarity) create flow, indicating a research gap. To fill this gap, we use the cognitive gaming elements in the literature and the theoretical elements of goal-setting theory to build a model.Design/methodology/approachConducting a large-scale online survey, we collect 3,491 responses from online game players and use structural equation modeling for data analysis.FindingsWe find that challenging goals, game complexity, game familiarity and telepresence are positively linked to player-perceived flow, explaining 45% of the variance. The new finding is that challenging goals can strengthen the link between game complexity and flow. We also find that telepresence can strengthen the link between game familiarity and flow.Originality/valueOur study provides the novel insight that gaming goals and cognitive gaming elements can generate player-perceived flow. This insight can help game makers design gaming elements to accommodate players' cognitive efforts to achieve in-game goals, thus creating flow and effectively increasing players' game engagement.
Factors affecting artificial intelligence (AI) adoption in the talent acquisition process: the case of Vietnam’s medium-sized firms
Authors: Cao Tri Minh , Nguyen Loc Thi Vy 
Published: November 2024

Purpose
This study aims to assess the factors that impact the adoption of artificial intelligence (AI) in the human resource (HR) recruitment procedure in Vietnam’s medium-sized firms.

Design/methodology/approach
Through a quantitative approach, this paper collected data of 297 hiring managers, HR directors and top-level executives from Vietnam’s medium-sized firms with a structured questionnaire. The partial least squares structural equation model was used to analyze the data and evaluate the hypothesis model (on platform Smart PLS 3.0).

Findings
The results show that in Vietnam’s medium-sized companies, both perceived benefits and perceived sacrifices directly impact on perceived value, which leads to organizations’ adoption of AI. HR readiness also has a moderating effect between perceived value and AI adoption.

Research limitations/implications
Future research can compare AI adoption between large and medium companies, as well as other criteria in Asian countries. Other organizational constructs can be considered moderators between perceived value and AI adoption.

Practical implications
This study offers a context-specific understanding of the practice of using AI to acquire talent in Vietnam. Both of AI technology’s perceived benefits and perceived sacrifices directly impact its perceived value, therefore indirectly impacting its adoption. In this study, HR readiness serves as an inhibitor to adoption. Some essential managerial implications are suggested.

Originality/value
This study provides valuable insights into applying AI to Vietnam’s medium-sized companies, especially in the recruitment process. It adds to a substantial body of work on applying AI to HR management.
Theoretical study of the solution of the diffusion equation under effect of the magnetic field on the silicon solar cell
Authors: Khalis M. , Masrour R. 
Published: November 2024

PurposeThe purpose of this study is to investigate the behavior of a silicon solar cell when subjected to a magnetic field. Specifically, the study aims to understand how the presence of the magnetic field influences the distribution of excess minority carriers within the base region of the solar cell. By solving the one-dimensional continuity equation under these conditions, the study seeks to elucidate the transient dynamics of carrier generation, recombination and transport processes. This research contributes to the broader understanding of how external magnetic fields can impact the performance and efficiency of silicon solar cells, potentially informing future optimizations or applications in photovoltaic technology.Design/methodology/approachThe solar cell is assumed to be uniformly illuminated, which simplifies the analysis of carrier generation to a function of depth (x). The emitter and space charge region contributions are considered while neglecting the diffusion region. The injection level remains constant throughout the analysis, focusing specifically on the base thickness region, H = 200 µm.FindingsThe findings of this study reveal significant insights into the behavior of a silicon solar cell under the influence of a magnetic field. Key findings include Impact on carrier distribution: the magnetic field affects the distribution of excess minority carriers within the base region of the solar cell. This distribution is crucial for understanding the efficiency of carrier collection and overall cell performance. Transient dynamics: the transient behavior of carrier generation, recombination and transport processes in the base region is influenced by the magnetic field. This understanding helps in predicting the response time and effectiveness of the solar cell under varying magnetic field strengths. Optimization potential: insights gained from this study suggest potential strategies for optimizing the design and operation of silicon solar cells to enhance their performance in environments where magnetic fields are present. Theoretical framework: the study provides a theoretical framework based on the one-dimensional continuity equation, offering a systematic approach to analyzing and predicting the behavior of solar cells under magnetic field conditions. These findings contribute to advancing the understanding of how external factors such as magnetic fields can impact the operation and efficiency of silicon solar cells, thereby guiding future research and development efforts in photovoltaic technology.Originality/valueThe originality and value of this study lie in its contribution to advancing the understanding of how magnetic fields influence silicon solar cell performance, providing both theoretical insights and potential practical applications in diverse technological contexts.
Sustainable warehouse management: a literature review and future research agenda
Authors: Kumar Vishwajit , Adil Gajendra Kumar 
Published: November 2024

Purpose
Warehouses, essential nodes in the supply chain, significantly contribute to sustainability issues, accounting for about 11% of emissions related to logistics activities. The purpose of this study is to review articles on sustainable warehouse management (SWM) from the Scopus database to analyze trends, synthesize existing knowledge, and identify research gaps for future studies.

Design/methodology/approach
The review uses text mining of initial relevant documents to create a search string for paper retrieval. Text mining is further used to generate a dendrogram of the most frequently used words in the research papers, which is then analyzed to identify themes and sub-themes in SWM.

Findings
The dendrogram reveals four major themes and their sub-themes within SWM, including two novel themes: sustainable warehouse in green logistics and sustainable warehouse location. In addition, 12 research recommendations are identified through content analysis and are subsequently linked to specific Sustainable Development Goals (SDGs).

Research limitations/implications
The methodological innovation in keyword selection for searching relevant papers and identifying themes serves as a structured template for researchers to explore further.

Practical implications
The research recommendations, aligned with the SDGs, aim to assist managers in making informed decisions and operational strategies to enhance factors associated with the Building Research Establishment Environmental Assessment Method and the sustainable performance of warehouses.

Originality/value
This study is novel in its application of text-mining techniques to generate a search string for identifying relevant papers and discerning themes by analyzing the dendrogram.
Who’s in? Variance in top management team definition effect on corporate political activity
Authors: Johnson Andrew F. , McDonald Aaron T. 
Published: November 2024

Purpose
Causal relationships between top management team (TMT) characteristics and corporate political activity (CPA) are well established in management literature. Yet, recent research has uncovered that there is little consistency in how researchers operationalize the TMT. Thus, the purpose of this paper is to empirically demonstrate how variation in TMT operationalization can affect causal relationships between TMT characteristics and CPA. Theoretical implications for these findings are discussed.

Design/methodology/approach
This study examines how varying the operationalization of the TMT affects the statistical outcomes of random-effects negative binomial regression models that examine how the state-level CPA of the largest 100 firms headquartered in Texas (from 2000 to 2010) is influenced by TMT characteristics.

Findings
How the TMT is operationalized greatly affects the level and significance of study results. These findings inform TMT and CPA research theoretically and statistically.

Research limitations/implications
This study underscores the importance of definition of TMT in studies where it is a variable.

Originality/value
This study provides novel insights into how TMT operationalization can greatly affect TMT research and theory.
Market transparency and consumer search—Evidence from the German retail gasoline market
Authors: Martin Simon 
Published: November 2024

AbstractWe estimate a model of incomplete information price competition where consumers endogenously choose whether to use a price search website. We examine how consumer search and prices would change under different transparency regimes. We find that aggregate consumer welfare is maximized when the price search website lists the lowest 20% of prices (i.e., one station in markets with less than five stations, and two stations in markets with more than five stations), with consumer expenditures falling by 1.5% relative to a regime where all are listed.
Biased bureaucrats and the policies of international organizations
Authors: Lang Valentin , Wellner Lukas , Kentikelenis Alexandros 
Published: November 2024

AbstractThis article advances a novel argument about the policy output of international organizations (IOs) by highlighting the role of individual staffers. We approach them as purposive actors carrying heterogeneous ideological biases that materially shape their policy choices on the job. Pursuing this argument with an empirical focus on the International Monetary Fund (IMF), we collected individual‐level information on the careers of 835 IMF “mission chiefs”—staffers with primary responsibility for a particular member state—and matched them to newly coded data on more than 15,000 IMF‐mandated policy conditions over the 1980–2016 period. Leveraging the appointment of the same mission chief to different countries throughout their career, we find that individual staffers influence the number, scope, and content of IMF conditions according to their personal ideological biases. These results contribute to our understanding of the microfoundations behind IO output and have implications for the accountability and legitimacy of IOs.
Clinical analysis of supraciliary effusion development following gonioscopy‐assisted transluminal trabeculotomy surgery for pseudoexfoliation glaucoma
Authors: Gunay Murat , Uzun Burak , Turk Adem , Kose Busra , Uzlu Dilek 
Published: November 2024

AbstractPurposeTo investigate clinical characteristics of postoperative supraciliary effusion (SCE) development following gonioscopy‐assisted transluminal trabeculotomy (GATT) in patients with pseudoexfoliation glaucoma (PEXG).MethodsIn this prospective and observational study, 64 eyes (64 patients) with PEXG were examined with spectral‐domain optical coherence tomography (SD‐OCT) after GATT over a 12‐month follow‐up. Outcomes were surgical success, intraocular pressure (IOP), best‐corrected visual acuity (BCVA), number of antiglaucoma medications (AGM) and complications of the SCE (+) group with those of SCE (−) group.ResultsSCE was observed in 39 eyes (60.9%) within the first postoperative week. Probability of complete success was significantly higher in the SCE (+) group than in the SCE (−) group (25.6% vs. 16.0%, p = 0.009). IOP was significantly lower at postoperative first day in the SCE (+) group than in the SCE (−) group (p = 0.04), but it was similar thereafter during follow‐up (p > 0.05). Postoperative BCVA did not show significant difference at the end of the follow‐up (p > 0.05). Postoperative number of AGM was found to be significantly lower in the SCE (+) group compared to the SCE (−) group (p < 0.05). A significant IOP rise was observed after SCE resolution (p = 0.002).ConclusionPresence of SCE accompanied with significantly lower IOP during the early postoperative period after GATT surgery for PEXG. SCE might have a favourable impact on postoperative AGM use. SCE can easily be examined by SD‐OCT, and be used as a prognostic indicator.
Dating an ancient spring tunnel using archaeological artefacts functioning as nuclei of cave pearls
Authors: Yechezkel Azriel , Vaknin Yoav , Cooper‐Frumkin Shlomit , Ryb Uri , Shaar Ron , Gadot Yuval , Frumkin Amos 
Published: November 2024

AbstractCave pearls are spherical concentric speleothems growing radially around nuclei in shallow pools saturated with calcite. They are very rare in the Southern Levant. We present a unique assemblage of 50 cave pearls found in the Iron Age Joweizeh artificial spring tunnel in the Jerusalem Hills of Israel. Some of these deposits represent the first global evidence of formation on archaeological artefacts: pottery sherds and ancient plaster. Multi‐analyses were conducted to date and characterize the different nuclei and pearls. Charcoal samples extracted from the plaster nuclei of two pearls were 14C dated to the Hellenistic period. Two pearls were formed on sherds of Hellenistic lamps. XPS found Co colour remains, suggesting both had been imported. The Hellenistic date is also supported by archaeomagnetic dates of seven other pottery nuclei. Most Hellenistic remains are probably the outcome of a renovation campaign in the tunnel. Four pearls were sampled for stable isotopes (δ13C and δ18O). The range of δ18O values from the Joweizeh pearls is compatible with the Holocene Soreq and Jerusalem caves’ records. The δ13C differences between Joweizeh and Soreq indicate local changes in the overlying vegetation throughout history. The various lines of evidence enabled us to characterize the pearls’ formation process, reconstruct the Joweizeh spring tunnel's hydraulic environment and detect changes that occurred in its water flow regime throughout history.
Delaying pegaspargase during induction in adults with acute lymphoblastic leukaemia is associated with lower risk of high‐grade hepatotoxicity without adversely impacting outcomes
Authors: Tinajero Jose , Xu Sharon , Ngo Dat , Li Shanpeng , Palmer Joycelynne , Nguyen Tina , Stein Anthony , Koller Paul , Agrawal Vaibhav , Pourhassan Hoda , Murphy Lindsey , Forman Stephen , Douer Dan , Marcucci Guido , Pullarkat Vinod , Aldoss Ibrahim 
Published: November 2024

SummaryPegaspargase is a key drug for the treatment of younger adults with acute lymphoblastic leukaemia (ALL). Pegaspargase‐associated hepatotoxicity is most common during induction, and its incidence increases with age and body mass index (BMI). We hypothesized that the delayed administration of pegaspargase during induction is associated with lower risk of hepatotoxicity while retaining efficacy. We retrospectively reviewed 141 adult patients with newly diagnosed ALL who received pegaspargase during induction from November 2013 to February 2024. There were 78 (55.3%) patients who received early pegaspargase (EP) on day 4 and 63 (44.7%) patients who received delayed pegaspargase (DP) on day 15. High‐grade hepatotoxicity (grade ≥ 3 transaminitis and/or hyperbilirubinaemia) occurred more frequently in the EP group (p = 0.06). Rates of complete remission and negative minimal residual disease post induction were not different between cohorts. Univariate logistic regression analysis showed that BMI and age significantly predicted an increased risk of high‐grade hepatotoxicity while DP was associated with a lower risk (odds ratio = 0.44; p = 0.04). Overall survival and event‐free survival were not significantly different between cohorts. Delaying pegaspargase administration from day 4 to day 15 during induction cycle in adults with ALL might reduce the risk of high‐grade hepatotoxicity without adversely impacting clinical efficacy outcomes.