bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Factors of Hospital Mortality After Near Hanging: A Retrospective two-Center French Study
Authors: Gueddoum Yanis , Goury Antoine , Legros Vincent , Floch Thierry , Mourvillier Bruno , Thery Guillaume 
Published: December 2024

Introduction suicide is a global public health issue, with over 800 000 people taking their own lives every year. However, most suicide attempts do not result in death. Hanging is the most common method used in France, often leading to post-hanging coma (PHC). The prognosis for patients admitted in intensive care unit (ICU) following PHC is poor, yet predictive criteria of mortality have been poorly evaluated. Methods we retrospectively collected prehospital and in-hospital data from 65 patients hospitalized in 2 French ICU for PHC, between first March 2010 and first August 2023, and compared characteristics between patients alive and dead. Results hospital mortality was 52%. Among baseline characteristics, SAPSII and pre-hospital cardiac arrest were associated with mortality, respectively 47 versus 62 ( P = .005) and 32% versus 85% ( P = .001). Concerning neuroprognostication, abnormal pupillary light reflex (PLR) was more frequent in patients who died (14% vs 56%, P = .002), as abnormal EEG (0% vs 32%, P = .002) and abnormal transcranial doppler (10% vs 35%, P = .031). Conclusion we identified several poor prognostic factors associated with hospital mortality after PHC. Further larger-scale studies are needed to supplement these findings.
Cisplatin in Combination with Apigenin Inhibits Human Osteosarcoma Cells Proliferation by Promoting Osteogenic Differentiation:  A Mechanistic Insight
Authors: Alqarni Abdullah , Hosmani Jagadish , Assiri Khalil , Alassiri Saeed , Alqahtani Ali Mosfer 
Published: December 2024

Background Osteosarcoma, the predominant primary bone cancer in the pediatric and adolescent population globally, exhibits a relatively low annual incidence but contributes significantly to morbidity and mortality. Purpose: The current study aims to explore the impact of cisplatin, apigenin, and their combination on human osteosarcoma cell line (MG-63) osteosarcoma cells, given the challenges in clinical treatment such as chemotherapy’s adverse effects, resistance development, and relapses. Methods Cytotoxicity assessment using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was conducted for cisplatin, apigenin, and their combination. Apoptotic potential was evaluated through ethidium bromide (EtBr)/acridine orange (AO) dual staining for the combination treatment. Reactive oxygen species (ROS) production and cell cycle arrest were analyzed posttreatment with the cisplatin + apigenin combination using 2′-7′-dichlorodihydrofluorescein diacetate (DCF-DA) staining and fluorescence-activated cell sorting (FACS) analysis, respectively. Proapoptotic and antiapoptotic gene expression was assessed via quantitative polymerase chain reaction (qPCR) analysis. Additionally, messenger ribonucleic acid (mRNA) and protein expression of B-cell-specific Moloney murine leukemia virus integration site 1 (BMIL1) were analyzed in both untreated and cisplatin + apigenin treated cells. Enzyme-linked immunosorbent assay (ELISA) analysis was performed for p16INK4a, E-cadherin, and Notch1. Results Results indicated that the combination treatment significantly inhibited MG-63 cell proliferation compared to individual treatments. Enhanced apoptosis and ROS production were observed in the combination treatment, along with cell cycle arrest at the sub G0- G1 phase. Furthermore, the combination downregulated BMIL1 and Bcl2 expression while upregulating mRNA expression of Bax, Caspase 3, Caspase 9, Apaf-1, and p53. Gene expression results corroborated BMIL1 downregulation in the combination treatment. Additionally, protein levels of p16INK4a and E-cadherin were significantly decreased in the combination treatment compared to individual treatments and untreated control. Conclusions In conclusion, cisplatin and apigenin combination exhibited superior efficacy against osteosarcoma.
A comparison of two law enforcement marksmanship assessments
Authors: Orr Robin Marc , Canetti Elisa Fontenelle Dumans , Schram Ben 
Published: December 2024

Background: Law enforcement officers (LEO) must be confident in their ability to employ their firearm and be accurate in its application in high stress, life threatening, situations. To assess officer firearm marksmanship and training needs, police officers are assessed annually on their firearm handling and shooting accuracy. The unknown is whether different marksmanship assessments may yield different results in officer qualification rates, and measures of officer firearm comfort, confidence, and safety. Objective: This study aimed to identify differences in officer firearm qualification rates and perceptions of comfort, confidence, and safety in the handling of their firearms between their current Traditional Pistol Assessment (TPA) and an Alternate Pistol Assessment (APA). Methods: Australian LEO (male n = 8; female n = 6) consented and participated in a cross sectional, within-subjects, randomised, repeated measures study. Subjective data (e.g. perceived confidence), objective data (e.g. heart rate and breathing rate), and marksmanship qualification results were collected for both assessments. Results: Four (29%) officers passed the TPA, while seven (50%) passed the APA. While more complex, officers had greater confidence in their sidearm handling and marksmanship ability following the APA. There were no significant differences in physiological demands between the two assessments. Conclusions: Officer firearm qualification rates are influenced by the nature of the marksmanship assessment undertaken as are their perceptions of firearm comfort, confidence, and safety when handling and firing their firearm. A firearms qualification assessment should include a variety of occupationally relevant situations (e.g. moving, shooting from behind cover, vocalisation, etc.), and consider impacts on officer firearms confidence.
Health threats to Polish firefighters during vehicle fires – analysis of fire and rescue operations in Poland in 2017–2022
Authors: Dudziński Łukasz , Bihałowicz Jan Stefan , Weiner Marcin , Kasperczyk Rafał , Kubiak Tomasz 
Published: December 2024

Background Firefighters while extinguishing fires, are exposed to air pollution resulting from combustion processes, especially dangerous when originating from the combustion of plastics. Air pollution during a fire results from the release of gases, vapors, smokes, and dusts of varying composition and toxicity levels into the atmosphere. Objective To analyse and estimate the health hazards to firefighters resulting from exposure to harmful chemical compounds generated during vehicle fires in Poland between 2017 and 2022. Methods Data from the Decision Support System of the State Fire Service (DSS-SFS), provided by the Operational Planning Office, were used. Events from the period 1st January 2017—31st December 2022 were analysed. Quantitative data were described using the mean (Mean) and standard deviation (SD). Correlations and differences at the significance level of p < 0.05 were considered statistically significant. The analysis is anonymous for both the victims and the officers involved in the described fire and rescue operations. Results According to the DSS-SFS system records, firefighters carried out n = 55,422 (min 8441, max 9847, mean 9237, SD 494.2) fire interventions (F), in the category of object: motor vehicles, during 2017–2022. The maximum firefighting operation times were observed for trucks, which may result from the purpose of these vehicles (carrying loads), the necessity of firefighting operations in the cargo space and the transported materials. Conclusion Attention should be paid to the various possibilities of exposure to fire substances, not only directly at the source of combustion but also in the fire engine, on protective clothing, firefighting equipment, which can cause secondary exposures long after the firefighting operation has ended, and the correct decontamination process..
Levator Veli Palatini Muscle Ratio Is a Clinically Significant Anatomic Predictor for Velopharyngeal Surgical Need
Authors: Mason Kazlin N. , Gampper Thomas , Black Jonathan 
Published: December 2024

Objective Velopharyngeal insufficiency (VPI) poses challenges for normal speech production, often necessitating surgical intervention. Determining optimal candidates for surgery remains complex and requires a nuanced understanding of underlying anatomic factors contributing to VPI. This study aimed to identify anatomic predictors that drive surgical recommendations for VPI. Design Prospective observational cohort study. Setting Pediatric tertiary care hospital. Methods Magnetic resonance imaging data were acquired from 150 children (aged 4–17) to identify anatomic predictors of VPI and surgical need. Fourteen velopharyngeal variables were measured in the oblique coronal and midsagittal imaging planes. Calculations included differences in levator veli palatini (LVP) muscle angles of origin, mean extravelar length, differences between left and right extravelar segments, the VP Needs ratio, and a newly developed LVP ratio. Multivariate logistic regression models with k-fold cross validation were utilized to identify anatomic profiles predictive of VPI and receiving a surgical recommendation. Results The models demonstrated high accuracy, sensitivity, and specificity. Among anatomic variables, the LVP ratio emerged as the strongest determinant of surgical need (β = 11.256, p < .001). Notably, an increase in the LVP ratio of 0.10 is associated with a 3.08-fold increase in the likelihood of receiving a surgical recommendation. LVP ratios above 1.0 were significant for both VPI classification and surgical need. Conclusions The LVP ratio significantly differentiates individuals with VPI and is predictive of surgical need for VPI management. Inclusion of the LVP ratio into clinical evaluations may refine patient stratification, enabling more precise surgical decision-making tailored to individual anatomic variations.
Dynamics of phonetic-level language control in language switching with a letter-naming paradigm
Authors: Zhang Yong , Ji Feng , Li Ya , Yue Chang , Guo Huan , Damian Markus F. 
Published: December 2024

Aims: How bilinguals control multiple languages is the object of intense recent scientific debate. Empirical research on language control at various linguistic levels has remained scarce, with language control at the phonetic level particularly underexplored. The present study aimed to examine the dynamics of phonetic-level language control during speech production. Design: Chinese-English-German speakers named the letter of the alphabet in English (L2) or German (L3), either in single-language blocks or in alternate-language mixed blocks. Letters vary regarding how phonetically similar pronunciation is across the two languages, hence allowing to explore cross-language phonetic influences. Data and analysis: Three-way repeated-measures analysis of variance (ANOVA) with trial type (non-switch vs. single-language for mixing costs; non-switch vs. switch for switch costs), response language (English/L2 vs. German/L3), and phonetic similarity (similar vs. neutral vs. different) as variables were conducted on 52 subjects’ response times and accuracy for mixing costs and switch costs, respectively. Findings: Results showed substantial mixing and switch costs, as well as a “reversed language dominance” effect, suggesting inhibitory control in response to cross-language phonetic interference. Cross-language facilitation was observed for phonetically similar letters, and mixing/switch costs were modulated by phonetic similarity in a complex pattern. Originality: The findings show a complex interplay of suppression (e.g., as indexed by switch costs) and facilitation (i.e., the effect of phonetic similarity between letter translation equivalents). Significance: The evidence for cross-language phonetic interference as well as facilitation effects at local and global levels of control implies a dynamic interaction between the two phonetic systems.
Do Green Spaces Mitigate Mental Health Disorders in Tehran? Evidence from 358 Neighborhoods
Authors: Shahabi Shahmiri Mojtaba , Boujari Pouria , Sadat Fazeli Dehkordi Zeynab , Khatami Seyed Mahdi 
Published: December 2024

Background With a prevalence of mental disorders affecting 18 out of every 100 Iranians and a rising urban population, it is crucial to examine the impact of built environments on people's well-being. Objective While some studies have conducted individual-level surveys in Iran, this research aims to investigate the potential impact of green spaces on mental health at the neighborhood level in Tehran. Method Using secondary data from 358 neighborhoods in Tehran in 2011, a linear regression analysis was conducted to investigate the correlation between four green space indicators and three mental health metrics. Results The results indicate that green space indicators have the potential to mitigate mental disorders in Tehran, with accessibility to green spaces emerging as the most impactful factor among those studied on mental disorders and anxiety. However, no significant association was found with depression when considering intervening variables. The study also found that other green space indicators, such as the ratio of green space in neighborhoods and satisfaction with green spaces, did not show significant effects, underscoring the importance of accessibility over size or quantity of green spaces per person. Additionally, our findings suggest that higher levels of unemployment in neighborhoods have a more pronounced impact on mental disorders among sociodemographic factors. Conclusion Urban planners and designers should prioritize equitable access to green spaces within neighborhoods, rather than focusing solely on size or per capita availability. Additionally, policymakers should recognize that addressing both environmental and socioeconomic factors—rather than just one–can effectively alleviate residents’ mental health issues.
User-centered design and development of a web-based tool to support healthy feeding practices by parents of urban minority youth at risk for childhood obesity
Authors: Mateo Katrina F , Vilme Helene , Verdaguer Sandra , Fuqua Abigail , Hoyt Kris , Davis Jacquelyn , Leung May May 
Published: December 2024

Objectives Technology, mobile health (mHealth), and “eHealth” are broadly used in childhood overweight and obesity interventions. However, the impact of technology-based interventions where parents or caregivers are involved is unclear. Thus, the objective of this manuscript is to provide valuable insights about the development of a parent–child web-based tool to promote healthy eating among preadolescents. Methods The tool development was an iterative process and comprised of two phases. In Phase 1, formative research (focus groups and interviews) were conducted with parents of children around the topics of dietary behaviors, technology use, and proposed intervention components. In Phase 2, a brief survey, focus groups, interviews, and user-centered approaches were used to confirm/finalize content, assess the website wireframe, and conduct usability testing. Results From the Phase 1 formative research, parents preferred reading/looking up health-related information on larger laptop/tablet screens, but preferred smartphones when reading “on-the-go.” Suggestions for an online health tool included quick/easy/low-cost recipes, tips for healthy feeding and involving their children around healthy dietary-related behaviors, clear tool navigation, and using pictures/visuals. In Phase 2, when finalizing the tool wireframe and content, parents preferred a variety of motivational healthy feeding tips, local family-oriented community events, and a simple layout with minimal clicking to access links. During usability testing, parents responded positively to the content (healthy feeding tips, recipes, coupons, and free community events) and the clean layout. Conclusions Formative research and user-centered approaches with parents of preadolescents resulted in a web-based, mobile-friendly health promotion tool.
Decreasing Incidence of Youth Wrestling Injuries: A 10-Year Analysis of National Injury Data
Authors: Snyder Eli M. , Obana Kyle K. , Abdelaziz Abed , Parisien Robert L. , Ahmad Christopher S. , Popkin Charles A. , Trofa David P. 
Published: December 2024

Background: Wrestling is among the most common youth sports in the United States, with about 260,000 high school participants annually. There is a lack of literature investigating wrestling injury profiles and mechanisms of injuries. In the past 15 years, urgent care utilization has increased, and National Federation of State High School Associations (NFHS) concussion protocols have been developed and implemented. Purpose/Hypothesis: The purpose of this study was to analyze causes, diagnoses, body parts, and trends associated with wrestling injuries presenting to US emergency departments. It was hypothesized that there would be (1) decreased overall injuries presenting to emergency departments because of increased urgent care utilization and (2) decreased concussions because of the NFHS rule implementation and revision. Study Design: Descriptive epidemiology study; Level of evidence, 3. Methods: Youth wrestling injuries presenting to US emergency departments between January 1, 2013, and December 31, 2022, were queried from the National Electronic Injury Surveillance System database. The data included date of presentation, age, sex, race, body part, injury diagnosis, disposition, and a brief injury narrative. National estimates (NE) were calculated using the associated statistical weight of the reporting hospital. Linear regressions were performed to investigate the relationship between year and NE for overall injuries, diagnoses, body parts, mechanisms of injury, and other subanalyses. Statistical significance was set at P < .05. Results: A total of 8628 (NE = 296,502) wrestling injuries met the inclusion criteria for this study. The mean age at presentation was 14.3 ± 2.6 years (range, 3 to 18 years). The shoulder (NE = 43,207 [14.6%]), head (NE = 40,875 [13.8%]), and knee (NE = 30,218 [10.2%]) were the most injured body parts. The most common diagnoses were strain/sprain (NE = 91,924 [31%]), other/not stated (NE = 53,736 [18.1%]), and fracture (NE = 52,261 [17.6%]). Common mechanisms of injury included not specified (NE = 148,169 [50%]), impact with mat (NE = 61,557 [20.8%]), and abnormal rotation/strain (NE = 37,449 [12.6%]). Overall injuries ( P = .01) (coefficient: –1763 [95% CI, –2963 to −563]) and concussions ( P = .01) (coefficient: –178 [95% CI, –302 to −55]) statistically significantly decreased. Conclusions: Our study showed a trend in the decrease in overall injuries and concussions in high school wrestlers. Strains/sprains were the most common diagnoses with the shoulder being the most common site. Youth wrestlers would benefit from future research analyzing risks associated with these injuries as well as advances in protective gear.
Azacytidine Plus PD-1 Therapy in Relapsed or Refractory Hodgkin Lymphoma
Authors: Qian Liren , Zhu Haiyan , Liu Yu , Ding Mingshuang , Bumbea Horia , Tomuleasa Ciprian 
Published: December 2024

Background: The treatment of relapsed or refractory (R/R) Hodgkin lymphoma (HL) remains challenging. Azacitidine has been demonstrated enhancing PD-1 expression in vivo. The aim of this study is to evaluate the safety and efficacy of azacitidine when given together with PD-1 therapy(AP) in treating patients with relapsed/refractory classic Hodgkin lymphoma.
Methods: Adult patients with R/R HL who had progressed after at least 1 prior line of therapy were enrolled to receive Azacytidine(75 mg/m2 qd on days 1-7) plus PD-1 therapy(200mg qd on day 8). Treatment continued until disease progression or unacceptable toxicity occurred post CR. Patients discontinue treatment after 2 years of sustained CR (NCT06190067).
Results: 2 patients with R/R HL were enrolled. Patient 1 received complete remission after two cycles of ABVD, but relapsed after six cycles of ABVD. Patient 1 then received complete remission again after four cycles of DP（Decitabine pus PD-1 therapy）, but relapsed again after six cycles of DP. Then, the patient received complete remission the third time after 3 cycles of AP and received AP maintenance therapy. The patient is still in complete remission until now (8 months). Patient 2 received partial remission after two cycles of ABVD，but progressed after four cycles of ABVD. Patient 2 received complete remission after 3 cycles of AP and received AP maintenance therapy. The patient is still in complete remission until now (9 months).
Conclusion: This study found that the AP regimen was effective and safe in patients with R/R HL after multiline therapy. Surprisingly, in the patient who relapsed after demethylated drug decitabine plus PD-1 therapy, AP regimen also showed a better response. More R/R HL patients need to be enrolled and further prospective studies were warranted.
Enhancing Quality of Life in Myeloproliferative Neoplasms: Insights from Janus Kinase Inhibitors-a Comprehensive Review and Meta-Analysis
Authors: Shahzad Moazzam , Noor Jawad , Dave Prashil , Khalid Muhammad Fareed , Zaidi Maheen , Goyal Shriya , Naeem Ammad , Mir Waleed Ahmed , Anwar Iqra , Amin Muhammad Kashif , Jaglal Michael V. , Ammad Ud Din Mohammad , Mohammad Turab , Faisal Muhammad Salman 
Published: December 2024

Background
Patients with myeloproliferative neoplasms (MPN) are known to have a high symptomatic burden, impairing quality of life. While JAK inhibitors (JAKi) have been the therapeutic backbone for the treatment of MPN, only a few studies have focused on quality of life (QoL) aspects. This meta-analysis aims to explore the effects of JAKi on QOL in MPN.
Methods
Following PRISMA guidelines, PubMed, Cochrane Register of Controlled Trials, and Clinicaltrials.gov were searched using MeSH terms and keywords for “Myeloproliferative Disorder”, “Quality of Life”, and “Janus Kinase Inhibitors” from the date of inception to January 31, 2024. 17 out of 129 articles reporting QoL with the use of JAKi in MPN patients were included. The inter-study variance was calculated using the Der Simonian-Laird Estimator. Proportions along with a 95% confidence interval (CI) were extracted to compute pooled analysis using the “meta” package by Schwarzer et al. in the R programming language (version 4.16-2).
Results
A total of 2136 patients were included for analysis. The median age was 64.9 (26-90) years and 57.2% (1175-2055) were male. The median follow-up time was 6.5 (6-67) months. Most patients had MF 70.6%, followed by PV 17.6% (3/17), while ruxolitinib was the most commonly used JAKi 41.2%, followed by Momelotinib 23.5%, Pacritinib 11.7%, Fedratinib 17.6%, and Gandotinib 6%. The most commonly used questionnaire to assess for QoL was EORTC QLQ-C30, 41.2%. The mean percentage change in baseline score for fatigue, insomnia, and appetite loss was -8.2,-12.1, and -5.7, respectively. MPNSAF TSS was the most commonly used questionnaire to assess symptom score 88.2%. The pooled ≥50% symptoms improvement was 40.3% (95% CI 0.32-0.49, I2=85%, p&lt; 0.01 n=960), while the pooled spleen response, defined as at least a 35% reduction in spleen volume, was 29.1% (95% CI 0.21-0.38, I2=92%,p&lt; 0.01 n=1664). Anemia 31%, diarrhea 29.5%, thrombocytopenia 21.6%, and nausea 13.7% were the most commonly reported side effects, with a mortality rate of 10.7%.
Conclusions
This analysis shows symptomatic improvement as well as better QoL with JAKi in MPN patients. However, further randomized studies are needed to better delineate these findings and establish guidelines.