bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid imaging of dutch‐type hereditary cerebral amyloid angiopathy carriers
Authors: Schultz Aaron P. , Kloet Reina W. , Sohrabi Hamid R. , van der Weerd Louise , van Rooden Sanneke , Wermer Marieke J. H. , Moursel Laure Grand , Yaqub Maqsood , van Berckel Bart N. M. , Chatterjee Pratishtha , Gardener Samantha L. , Taddei Kevin , Fagan Anne M. , Benzinger Tammie L. , Morris John C. , Sperling Reisa , Johnson Keith , Bateman Randall J. ,   Dominantly Inherited Alzheimer Network, Gurol M. Edip , van Buchem Mark A. , Martins Ralph , Chhatwal Jasmeer P. , Greenberg Steven M. 
Published: July 2019

ObjectiveTo determine whether amyloid imaging with the positron emission tomography (PET) agent Pittsburgh compound B (PiB) can detect vascular β‐amyloid (Aβ) in the essentially pure form of cerebral amyloid angiopathy associated with the Dutch‐type hereditary cerebral amyloid angiopathy (D‐CAA) mutation.MethodsPiB retention in a cortical composite of frontal, lateral, and retrosplenial regions (FLR) was measured by PiB‐PET in 19 D‐CAA mutation carriers (M+; 13 without neurologic symptoms, 6 with prior lobar intracerebral hemorrhage) and 17 mutation noncarriers (M−). Progression of PiB retention was analyzed in a subset of 18 serially imaged individuals (10 asymptomatic M+, 8 M−). We also analyzed associations between PiB retention and cerebrospinal fluid (CSF) Aβ concentrations in 17 M+ and 11 M− participants who underwent lumbar puncture and compared the findings to PiB‐PET and CSF Aβ in 37 autosomal dominant Alzheimer disease (ADAD) mutation carriers.ResultsD‐CAA M+ showed greater age‐dependent FLR PiB retention (p < 0.001) than M−, and serially imaged asymptomatic M+ demonstrated greater longitudinal increases (p = 0.004). Among M+, greater FLR PiB retention associated with reduced CSF concentrations of Aβ40 (r = −0.55, p = 0.021) but not Aβ42 (r = 0.01, p = 0.991). Despite comparably low CSF Aβ40 and Aβ42, PiB retention was substantially less in D‐CAA than ADAD (p < 0.001).InterpretationIncreased PiB retention in D‐CAA and correlation with reduced CSF Aβ40 suggest this compound labels vascular amyloid, although to a lesser degree than amyloid deposits in ADAD. Progression in PiB signal over time suggests amyloid PET as a potential biomarker in trials of candidate agents for this untreatable cause of hemorrhagic stroke. ANN NEUROL 2019;86:616–625
Halogenid‐basierte Materialien und Chemie für wiederaufladbare Batterien
Authors: Zhao Xiangyu , Zhao‐Karger Zhirong , Fichtner Maximilian , Shen Xiaodong 
Published: July 2019

AbstractWiederaufladbare Batterien gelten als eine der effektivsten Energiespeichertechnologien, die die Überleitung zwischen der Erzeugung und dem Verbrauch erneuerbarer Energien schafft. Die weitergehende Entwicklung wiederaufladbarer Batterien mit Eigenschaften wie hohe Energiedichte, Kostengünstigkeit, Sicherheit und eine lange Lebensdauer muss dabei die stetig zunehmenden Energiespeicheranforderungen erfüllen. Dieser Aufsatz zeigt den wissenschaftlichen und technologischen Fortschritt wiederaufladbarer Batterien auf, der durch Halogenid‐basierten Materialien und Chemikalien zustande kommt, inklusive der Verwendung von Halogenid‐Elektroden, Halogendotierung von Elektroden und/oder Elektrodenoberflächen, Elektrolyt‐Design und Additive, die schnellen Ionen‐Shuttle und stabile Elektroden/Elektrolyt‐Grenzflächen ermöglichen sowie neue Batteriechemie realisieren. Eine Vielzahl von Batteriechemie basierend auf monovalentem Kation‐, multivalenten Kation‐, Anion‐ oder Dual‐Ionen‐Transfer wird beschrieben. Dieser Aufsatz zielt darauf ab, das Verständis von Halogenid‐basierten Materialien und Chemikalien zu fördern und die weitere Forschung und Entwicklung im Bereich hochleistungsfähiger wiederaufladbarer Batterien anzuregen. Er soll außerdem einen Ausblick auf die Nutzung neuer elektrochemischer Energiespeichermaterialien und ‐systeme bieten.
2D Poly(arylene vinylene) Covalent Organic Frameworks via Aldol Condensation of Trimethyltriazine
Authors: Jadhav Thaksen , Fang Yuan , Patterson William , Liu Cheng‐Hao , Hamzehpoor Ehsan , Perepichka Dmitrii F. 
Published: July 2019

AbstractDesigning structural order in electronically active organic solids remains a great challenge in the field of materials chemistry. Now, 2D poly(arylene vinylene)s prepared as highly crystalline covalent organic frameworks (COFs) by base‐catalyzed aldol condensation of trimethyltriazine with aromatic dialdehydes are reported. The synthesized polymers are highly emissive (quantum yield of up to 50 %), as commonly observed in their 1D analogues poly(phenylene vinylene)s. The inherent well‐defined porosity (surface area ca. 1000 m2 g−1, pore diameter ca. 11 Å for the terephthaldehyde derived COF‐1) and 2D structure of these COFs also present a new set of properties and are likely responsible for the emission color, which is sensitive to the environment. COF‐1 is highly hydrophilic and reveals a dramatic macroscopic structural reorganization that has not been previously observed in framework materials.
Halide‐Based Materials and Chemistry for Rechargeable Batteries
Authors: Zhao Xiangyu , Zhao‐Karger Zhirong , Fichtner Maximilian , Shen Xiaodong 
Published: July 2019

AbstractRechargeable batteries are considered one of the most effective energy storage technologies to bridge the production and consumption of renewable energy. The further development of rechargeable batteries with characteristics such as high energy density, low cost, safety, and a long cycle life is required to meet the ever‐increasing energy‐storage demands. This Review highlights the progress achieved with halide‐based materials in rechargeable batteries, including the use of halide electrodes, bulk and/or surface halogen‐doping of electrodes, electrolyte design, and additives that enable fast ion shuttling and stable electrode/electrolyte interfaces, as well as realization of new battery chemistry. Battery chemistry based on monovalent cation, multivalent cation, anion, and dual‐ion transfer is covered. This Review aims to promote the understanding of halide‐based materials to stimulate further research and development in the area of high‐performance rechargeable batteries. It also offers a perspective on the exploration of new materials and systems for electrochemical energy storage.
On‐Surface Reactive Planarization of Pt(II) Complexes
Authors: Ren Jindong , Cnudde Marvin , Brünink Dana , Buss Stefan , Daniliuc Constantin G. , Liu Lacheng , Fuchs Harald , Strassert Cristian A. , Gao Hong‐Ying , Doltsinis Nikos L. 
Published: July 2019

AbstractA series of Pt(II) complexes with tetradentate luminophores has been designed, synthesized, and deposited on coinage metal surfaces with the aim to produce highly planar self‐assembled monolayers. Low‐temperature scanning tunneling microscopy (STM) and density functional theory (DFT) calculations reveal a significant initial nonplanarity for all complexes. A subsequent metal‐catalyzed separation of the nonplanar moiety at the bridging unit via the scission of a C−N bond is observed, leaving behind a largely planar core complex. The activation barrier of this bond scission process is found to depend strongly on the chemical nature of both bridging group and coordination plane, and to increase from Cu(111) through Ag(111) to Au(111).
Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors
Authors: Soliman Beatrice , Wang Ning , Zagotto Giuseppe , Pockes Steffen 
Published: July 2019

AbstractRecent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR‐PI376, as highly potent agonists at the human histamine H4 receptor (hH4R). While imidazole‐containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six‐membered heterocycles (piperidine, morpholine, thiomorpholine, and N‐methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C3–C5) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand‐binding assays exhibited only very weak activity at the hH1R and hH3R, while nearly all compounds were inactive at the hH2R and hH4R. In the case of piperidine‐containing compounds, moderate affinities at the hH3R over the single‐digit micromolar range were detected.
Stabilizing Metal–Organic Polyhedra (MOP): Issues and Strategies
Authors: Mollick Samraj , Fajal Sahel , Mukherjee Soumya , Ghosh Sujit K. 
Published: July 2019

AbstractMetal–organic polyhedra (MOPs) are discrete, metal–organic molecular entities composed of edge‐sharing molecular polygons or connected molecular vertices. Unlike the infinite metal–organic coordination networks popularized by metal–organic frameworks (MOFs), spherical MOPs, also known as nanocages, nanospheres, nanocapsules, or nanoballs, are obtained through the self‐organization of metal–carboxylate or metal–pyridine/pyrimidine links to afford cage‐like nanoarchitectures. MOPs offer much promise as porous materials owing to their well‐defined structures and solution processability. However, these advantages become moot if their poor aqueous stability and/or guest‐removal‐induced aggregation handicaps remain unaddressed. The concise premise of this contribution limits our discussion to the design principles in action behind recent developments in stable carboxylate MOPs. To highlight the structure–property relationships between the structural and compositional features of these metal carboxylate polyhedra, related scientific challenges and state‐of‐the‐art research directions for further exploration are presented in brief.
Tag‐Convertible Photocrosslinker with Click‐On/Off N‐Acylsulfonamide Linkage for Protein Identification
Authors: Hayashi Ryuji , Morimoto Shota , Tomohiro Takenori 
Published: July 2019

AbstractThe N‐acylsulfonamide group, known as a safety‐catch linker, has been applied to photoaffinity labeling (PAL) using a cinnamate‐type photocrosslinker to improve the efficiency of PAL‐based target identification. A bioorthogonal sulfo‐click reaction was used to stably link a photocrosslinker unit with N‐acylsulfonamide linkage to produce a photoactivatable probe without any protection. In addition, the crosslinked protein was selectively isolated with a small cinnamate tag via linkage disruption upon N‐alkylation. Furthermore, the tag moiety was photochemically converted to a stable coumarin derivative by losing a water molecule, which is a useful property in MS‐based identification.
Predicting ships' CO2emissions using feature‐oriented methods
Authors: Reis Marco S. , Rendall Ricardo , Palumbo Biagio , Lepore Antonio , Capezza Christian 
Published: July 2019

AbstractShipping companies are forced by the current EU regulation to set up a system for monitoring, reporting, and verification of harmful emissions from their fleet. In this regulatory background, data collected from onboard sensors can be utilized to assess the ship's operating conditions and quantify its CO2emission levels. The standard approach for analyzing such data sets is based on summarizing the measurements obtained during a given voyage by the average value. However, this compression step may lead to significant information loss since most variables present a dynamic profile that is not well approximated by the average value only. Therefore, in this work, we test two feature‐oriented methods that are able to extract additional features, namely, profile‐driven features (PdF) and statistical pattern analysis (SPA). A real data set from a Ro‐Pax ship is then considered to test the selected methods. The data set is segregated according to the voyage distance into short, medium, and long routes. Both PdF and SPA are compared with the standard approach, and the results demonstrate the benefits of employing more systematic and informative feature‐oriented methods. For the short route, no method is able to predict CO2emissions in a satisfactory way, whereas for the medium and long routes, regression models built using features obtained from both PdF and SPA improve their prediction performance. In particular, for the long route, the standard approach failed to provide reasonably good predictions.
Functionalized pyrene‐based AIEgens: synthesis, photophysical characterization and density functional theory studies
Authors: Mohan Makesh , James Juliya , Satyanarayan M.N. , Trivedi Darshak R. 
Published: July 2019

AbstractThree new pyrene‐based derivatives P1, P2 and P3 with a substituted pyrazole were designed, synthesized and characterized using standard spectroscopic techniques. Ultraviolet–visible (UV–vis) spectroscopic studies for P1–P3 uncovered a finite bathochromic shift of the molecules in solvents of varying polarity. Photoluminescence (PL) studies revealed the significant fluorescence emission of all molecules in higher polar solvents such as MeOH and dimethylformamide (DMF). Fluorescence quantum yield studies demonstrated the importance of P3 possessing cyanofunctionality for imparting higher emission with a quantum yield of 0.36%. Ratiometric studies performed in a tetrahydrofuran (THF)/H2O mixture indicated fluorescence enhancement with increasing overall percentage of water, confirming the aggregation‐induced emission effect. Cyclic voltammetry study of molecules P1–P3 revealed an irreversible oxidation peak and the band gaps were calculated to be 2.26 eV for P1 and 2.31 eV for P2 and P3 respectively. Density functional theory (DFT) studies performed on molecules P1–P3 validate the structure correlation of the molecules. Theoretically estimated highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO) and bandgap correlated well with the experimental values. Furthermore, time‐dependent (TD)DFT showed that the major contribution for the electronic transitions occurring in the system was governed by HOMO‐1 and LUMO+1 orbitals.
Human entorhinal cortex electrical stimulation evoked short‐latency potentials in the broad neocortical regions: Evidence from cortico‐cortical evoked potential recordings
Authors: Takeyama Hirofumi , Matsumoto Riki , Usami Kiyohide , Nakae Takuro , Kobayashi Katsuya , Shimotake Akihiro , Kikuchi Takayuki , Yoshida Kazumichi , Kunieda Takeharu , Miyamoto Susumu , Takahashi Ryosuke , Ikeda Akio 
Published: July 2019

AbstractObjectiveWe aimed at clarifying the clinical significance of the responses evoked by human entorhinal cortex (EC) electrical stimulation by means of cortico‐cortical evoked potentials (CCEPs).MethodsWe enrolled nine patients with medically intractable medial temporal lobe epilepsy who underwent invasive presurgical evaluations with subdural or depth electrodes. Single‐pulse electrical stimulation was delivered to the EC and fusiform gyrus (FG), and their evoked potentials were compared. The correlation between the evoked potentials and Wechsler Memory Scale‐Revised (WMS‐R) score was analyzed to investigate whether memory circuit was involved in the generation of the evoked potentials.ResultsIn most electrodes placed on the neocortex, EC stimulation induced unique evoked potentials with positive polarity, termed as “widespread P1” (P1w). Compared with FG stimulation, P1w induced by EC stimulation were distinguished by their high occurrence rate, short peak latency (mean: 20.1 ms), small peak amplitude, and waveform uniformity among different recording sites. A stimulation of more posterior parts of the EC induced P1w with shorter latency and larger amplitude. P1w peak amplitude had a positive correlation (r = .69) with the visual memory score of the WMS‐R. In one patient, with depth electrode implanted into the hippocampus, the giant evoked potentials were recorded in the electrodes of the anterior hippocampus and EC near the stimulus site.ConclusionsThe human EC electrical stimulation evoked the short‐latency potentials in the broad neocortical regions. The origin of P1w remains unclear, although the limited evidence suggests that P1w is the far‐field potential by the volume conduction of giant evoked potential from the EC itself and hippocampus. The significance of the present study is that those evoked potentials may be a potential biomarker of memory impairment in various neurological diseases, and we provided direct evidence for the functional subdivisions along the anterior–posterior axis in the human EC.
Resilience of sustainability‐oriented and financially‐driven organizations
Authors: Carmeli Abraham , Dothan Ari , Boojihawon Dev Kumar 
Published: July 2019

AbstractTo answer key questions concerning how negative and positive financial performance gaps motivate organizations to build more resilient systems, we develop a conceptual process model to reveal the process by which financially and sustainability‐driven organizations can translate these negative and positive financial performance gaps into organizational resilience. We specify the different modes of search behaviors that these organizations pursue when encountering negative and positive financial performance gaps. We then expand on group engagement model to theorize that vicarious search is likely to encourage limiting behaviors, whereas internal search is likely to foster promotion behaviors. Finally, we explain how both promoting and limiting behaviors can be helpful in improving organizational resilience. In this way, we hope to advance research that connects and integrates relatively disparate realms and, more specifically, to contribute to the sustainability, resilience, and performance feedback literatures.
Corporates' strategic responses to economic policy uncertainty in China
Authors: Mirza Sultan Sikandar , Ahsan Tanveer 
Published: July 2019

AbstractUsing a novel news‐based index of economic policy uncertainty, this paper studies the impact of economic policy uncertainty on corporate strategic positioning and corporate risk in China from 2009 to 2015. The study also investigates the impact of corporate strategic positioning on corporate risk. The results show that corporate strategic positioning and economic policy uncertainty have a significant positive impact on corporate risk. The results also explain that economic policy uncertainty increases the market risk of the firms irrespective of their corporate strategy. However, it increases the business risk of prospector firms and decreases the business risk of defensive firms. The study may help the firms to formulate and improve their strategic positioning while considering economic policy uncertainty. Our results are robust to alternate proxies of economic policy uncertainty and corporate risk.
Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound‐guided radiofrequency ablation for papillary thyroid microcarcinoma
Authors: Zhang Yan , Zhang Ming‐bo , Luo Yu‐kun , Li Jie , Zhang Ying , Tang Jie 
Published: July 2019

AbstractBackgroundChronic lymphocytic thyroiditis (CLT) is an autoimmune disease commonly associated with papillary thyroid carcinoma characterized by a smaller primary tumor size at presentation. The efficacy and safety of ultrasound‐guided radiofrequency ablation (RFA) for papillary thyroid microcarcinoma (PTMC) coexisting with CLT is still unknown.MethodsSixty patients with unifocal PTMC were enrolled and classified into PTMC and PTMC+CLT groups (n = 30/group). CLT was diagnosed histopathologically. The ablation area exceeded the tumor margins, and was evaluated by US and contrast‐enhanced US (CEUS) for residual tumor to prevent recurrence. Three months after ablation, US‐guided core‐needle biopsy was performed to assess the presence of residual and recurrent cancer. Preoperative and postoperative data on patients and tumors were recorded and analyzed.ResultsThere were no differences between groups in age, sex, preoperative tumor volume, ablation time, or ablation power (P > 0.05). There was also no significant difference in postoperative ablation zone volume between the groups at the 1‐, 3‐, 6‐, 12‐, and 18‐month follow‐ups (P > 0.05). The volume reduction rate significantly differed between the two groups at month 3 (P = 0.03). The ablation area could not be identified on US and CEUS at 9.8 ± 5.0 and 10.0 ± 4.8 months in the PTMC and PTMC + CLT groups, respectively (P = 0.197). No serious complications occurred during and after ablation. No residual cancer cells were found on biopsy after ablation.ConclusionsRFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT.
Semi‐Batch Photocatalytic Reduction of Nitrates: Role of Process Conditions and Co‐Catalysts
Authors: Bahadori Elnaz , Tripodi Antonio , Ramis Gianguido , Rossetti Ilenia 
Published: July 2019

AbstractPhotocatalysis has been used to reduce nitrate ions from waste and drinking water. A semibatch photoreactor was developed for this process and commercial nanostructured TiO2 (P25) and TiO2 in nanosized form prepared by flame spray pyrolysis (FSP) were used as catalysts. Several noble metals were added as co‐catalyst on both titania samples and the chemical physical properties of every sample were studied by XRD, BET and UV‐Vis spectroscopy techniques. The optimum pH to reach the highest conversion of nitrates with lower selectivity toward ammonia was different for P25 and FSP samples, at basic pH and nearly neutral, respectively. The bare and doped FSP samples, with higher surface area, showed higher nitrates conversion with respect to P25‐based samples. The photocatalytic rate of nitrate reduction over undoped TiO2 was higher than that of most noble metal loaded TiO2, except Ag. The highest activity for nitrate conversion has been obtained by adding Ag on P25 and FSP, increasing the conversion up to 3.5 and 1.5 times with respect to the bare semiconductor, respectively.
New Insights into the Catalytic Activity of Cobalt Orthophosphate Co3(PO4)2from Charge Density Analysis
Authors: Keil Helena , Hellström Matti , Stückl Claudia , Herbst‐Irmer Regine , Behler Jörg , Stalke Dietmar 
Published: July 2019

AbstractAn extensive characterization of Co3(PO4)2was performed by topological analysis according to Bader‘s Quantum Theory of Atoms in Molecules from the experimentally and theoretically determined electron density. This study sheds light on the reactivity of cobalt orthophosphate as a solid‐state heterogeneous oxidative‐dehydration and ‐dehydrogenation catalyst. Various faces of the bulk catalyst were identified as possible reactive sites given their topological properties. The charge accumulations and depletions around the two independent five‐ and sixfold‐coordinated cobalt atoms, found in the topological analysis, are correlated to the orientation and population of the d‐orbitals. It is shown that the (011) face has the best structural features for catalysis. Fivefold‐coordinated ions in close proximity to advantageously oriented vacant coordination sites and electron depletions suit the oxygen lone pairs of the reactant, mainly for chemisorption. This is confirmed both from the multipole refinement as well as from density functional theory calculations. Nearby basic phosphate ions are readily available for C−H activation.