bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment Outcome of Macular Hole Associated with Rhegmatogenous Retinal Detachment
Authors: Okonkwo ON , Akanbi T , Onwuegbuna AA 
Published: December 2024

Background:
Macular holes are an infrequent association with rhegmatogenous retinal detachment, increasing the complexity of surgery and affecting outcome.

Aim:
To report the visual outcome, macular hole (MH) closure, and retinal reattachment rate after vitrectomy with silicone oil plus different MH closure techniques for MH associated with rhegmatogenous retinal detachment and to compare the visual outcome between the techniques.

Materials and Methods:
A retrospective, comparative study. Review of pre and postoperative Snellen best corrected visual acuity (BCVA) and the logarithm of minimum angle of resolution (LogMAR) conversion for nine eyes of 9 consecutively treated macular hole in rhegmatogenous retinal detachment patients. Pre and postoperative optical coherence tomography (OCT) macula scans and retinal reattachment three months post silicone oil removal were assessed.

Results:
Surgical techniques: Inverted internal limiting membrane flap (n = 4; 44.45%), internal limiting membrane (ILM) plug (n = 4; 44.45%), and autologous retinal transplant (n = 1; 11.1%). Outcome: Single-surgery retinal reattachment rate was 88.9% (8/9 eyes), and 100% with second surgery. Primary MH closure was 100%. One reopened MH with retinal re-detachment, post silicone oil removal, required additional surgery. The mean preoperative BCVA was 2.53 ± 0.93 LogMAR, and mean postoperative BCVA was 0.94 ± SD 0.43 LogMAR (P = 0.000). Mean change in Snellen line = 2.22 ± 1.72. The postoperative vision was the same as preoperative in 22.2% and improved in 77.8%. Mean postoperative vision for the inverted ILM flap group (n = 4) was 1.10 ± 0.62 LogMAR (P = 0.038), and for the ILM plug group (n = 4) 0.83 ± 0.23 LogMAR (P = 0.002). The surgical technique did not influence postoperative BCVA (P = 0.85). Only one eye had an outer retina on OCT evaluation. Complications were macular atrophy (55.6%), macular edema (44.4%), and epiretinal membrane (33.3%).

Conclusion:
Single-surgery retinal reattachment rate and macular hole closure using any of the techniques is high, and none showed superiority.
An In-vitro Evaluation of the Shear Bond Strength to Dentin and Microhardness of Different Restorative Materials Placed by Different Techniques
Authors: Nezir M , Özcan S 
Published: December 2024

Background:
The mentioned advantages of bulk-fill composite resin and high-viscosity glass ionomer restorative materials have increased their use in restorative dentistry in recent years; accordingly, the bonding of these materials to dental tissues and their mechanical properties have become more important.

Aim:
This study aimed to evaluate the effects of different application methods on Vicker’s hardness and shear bond strength of three different restorative materials.

Methods:
In this in-vitro study; Teflon molds were used for the microhardness test. In the control group, reinforced high-viscosity glass ionomer, high-viscosity glass ionomer, and flowable bulk-fill composite resin were applied by the manufacturer’s instructions. In other groups, preheating, ultrasonic activation, and both preheating and ultrasonic activation were applied, respectively (n = 14). Microhardness values of the upper surfaces of the specimens were measured with Vicker’s hardness measuring device. For the shear bond strength test, 84 intact human molar teeth were used. The teeth were sectioned two in the mesiodistal direction (n = 14). The materials were applied to the dentin using the same placement protocols as those used in the hardness test. After the specimens were maintained at 37°C for 24 h, the shear bond strength test was performed using a universal test device.

Statistical Analysis Used:
The data were analyzed using SPSS 26.0 at a 95% confidence level. The Mann–Whitney test was also used for the statistical analysis of the data (P = 0.05).

Results:
Preheating the restorative materials significantly decreased the shear bond strength in the flowable bulk-fill composite resin group (11.77 ± 4.46 MPa) compared with that in the control group (12.14 ± 4.23 MPa) (P < 0.05) but significantly increased the shear bond strength in the reinforced high-viscosity glass ionomer group (3.91 ± 2.93 MPa) (P < 0.05).

Conclusions:
It can be concluded that preheating before application may increase the shear bond strength of reinforced high-viscosity glass ionomer.
Pattern of Medication Adherence, Spirituality and Viral Load amongst Adult Patients on Highly Active Antiretroviral Therapy in Rural Southwest Nigeria
Authors: Olanrewaju Moronkeji Temitope , Olanrewaju Olatutu Ololade , Ibrahim Azeez Oyemomi , Ipinnimo Tope Michael , Ajayi Paul Oladapo , Sito Oluwafunmilayo Kehinde 
Published: December 2024

Introduction:
Previous studies have been conducted on medication adherence in Southwest Nigeria, but none of these has reported the relationship between highly active antiretroviral therapy (HAART) adherence, spirituality and viral load (VL) amongst people living with Human immunodeficiency virus (HIV)/AIDS, especially in rural settings of Southwestern Nigeria. This study assessed the pattern of medication adherence, spirituality and VL and ascertained the association of socio-demographics and spirituality on medication adherence amongst patients on HAART in rural Southwestern Nigeria.

Materials and Methods:
A hospital-based cross-sectional study involving 321 consented patients on HAART who were recruited by systematic sampling technique at the adult HIV clinic. Data were collected using an interviewer-administered questionnaire that assessed participants’ socio-demographic profiles, medication adherence and spirituality. Their blood samples were collected and their VLs were determined. The data were analysed using SPSS version 20. Logistic regression was done to identify the independent predictors of medication adherence.

Results:
The majority of the respondents reported a medium level of medication adherence (66.4%), a high level of spirituality (68.8%) and a low level of VL (67.3%). Amongst variables that had a statistically significant association with medication adherence were being educated, married, divorced, separated or widowed (P < 0.05). Furthermore, persons with high spirituality were 2.6 times more likely to be adherent to antiretroviral drugs when compared to persons with low spirituality (P < 0.05).

Conclusion:
It was shown that high spirituality is a positive predictor of medication adherence amongst patients on HAART. It, therefore, suggests that efforts deployed to improve the spirituality of these patients would most likely improve their medication adherence.
Phenotype and genetic spectrum of six Indian patients with bestrophinopathy
Authors: Shakeel Areeba , Bhatt Darshan M , Gopal Lingam , Raman Rajiv , Rao Chetan , Sripriya S. , Bhende Muna 
Published: December 2024

Abstract
The aim of this study is to describe genotype and phenotype of patients with bestrophinopathy. The case records were reviewed retrospectively, findings of multimodal imaging such as color fundus photograph, optical coherence tomography (OCT), fundus autofluorescence, electrophysiological, and genetic tests were noted. Twelve eyes of six patients from distinct Indian families with molecular diagnosis were enrolled. Exon 4 of BEST1 was mutated in 3 cases, while exons 2, 3, and 7 in others. Deletion is seen in Exon 7 and missense mutation in other exons. Sporadic autosomal dominant and recessive inheritance was observed in these families. Two patients had primary angle closure glaucoma with a history of consanguineous marriage and glaucoma in the family. Based on our findings, multifocal vitelliform subretinal deposits were the most common fundus finding in patients with autosomal recessive mutation while macular vitelliform lesion was seen with sporadic or autosomal dominant mutation; however, cosegregation analysis was not done. Baseline OCT showed macular and extramacular subretinal exudates, subretinal fluid, intraretinal cystic and schitic spaces, and thickened photoreceptors outer segment tips. Two patients developed abnormal vasculature and focal choroidal excavation in OCT. A severe reduction in the electro-oculogram Ardens ratio was noted while electroretinography was normal. Bestrophinopathy has a varied presentation with complex genotype-phenotype relationships. OCT is a noninvasive tool for monitoring and prognostication. Genetic testing of other family members should be facilitated.
A $2$-complex with contracting non-positive immersions and positive maximal irreducible curvature
Authors: Blufstein Martín Axel , Minian Elías Gabriel 
Published: December 2024

We prove that the

2

-complex associated to the presentation

\langle a,b \mid b,bab^{-1}a^{-2}\rangle

has contracting non-positive immersions and positive maximal irreducible curvature. This example shows that the contracting non-positive immersions property is not equivalent to the notion of non-positive irreducible curvature, answering a question raised by H. Wilton.
La machine à lire plurilingue : un outil numérique pour s’entrainer à lire en français langue seconde, en classe et à la maison
Authors: Perego Christine 
Published: December 2024

L’article présente la mise en œuvre expérimentale d’un outil pédagogique numérique provisoirement nommé « la machine à lire plurilingue » dans des classes accueillant des enfants migrant·e·s plurilingues. L’analyse croise des observations de classes et des entretiens avec des enseignant·e·s et des parents.
Activités plurilingues au secondaire Ponts entre l’éducation formelle et non formelle en Grèce et en France
Authors: Gatsi Giota , Dulong Stéphanie 
Published: December 2024

Nous présentons le fruit d’ateliers expérientiels et ludiques plurilingues menés auprès d’adolescents en Grèce et en France dans deux contextes différents : l’un formel, dans un collège grec, et l’autre en dehors de l’école, dans une association. Ces ateliers ont été menés dans les établissements des écoles privées (Grèce) dans le cadre des cours de français. Ils ont été réalisés en parallèle par l’association Croisée des langues dans le cadre d’activités périscolaires auprès d’adolescents résidant dans le 13e arrondissement de Paris. Les deux formatrices-chercheuses ont ainsi développé quatre activités plurilingues qui sont à la fois transférables en français et en grec et dans d’autres langues, tout en étant adaptables en contexte formel et non formel. Pour chacune de ces activités, une fiche synthétique utilisable par le formateur est proposée. Ainsi, les objectifs, le matériel nécessaire, la durée, les modalités pédagogiques et le déroulement de l’activité sont exposés afin que le formateur puisse découvrir et réaliser l’atelier avec les adolescents. À cela s’ajoutent des propositions d’adaptations établies suite aux expérimentations réalisées, ainsi que des photos illustrant les ateliers réalisés en Grèce et en France. Cette conception des activités avec des adolescents de différents pays a pour but d’enrichir la recherche sur la didactique du plurilinguisme et d’accompagner les adolescents dans leur construction identitaire en contexte scolaire et postscolaire.
Teaching how to build bridges between languages
Authors: Sielanko-Byford Elzbieta , Zielińska Janina 
Published: December 2024

The article presents examples of activities and tasks used during classes devoted to plurilingual education at the Centre for Foreign Language Teacher Training and European Education of the University of Warsaw. In the first part of the paper, the context in which future teachers of languages are educated at the Centre is described. The description focuses on the Plurilingual and Pluricultural Education course and the Integrated Language Didactics course, which enable students to become acquainted with the pluralistic approaches to languages and cultures and to further develop their plurilingual and pluricultural competence. These courses are an integral part of the programme of study at the Centre and it is assumed that the students will use the knowledge and skills acquired while attending them in their future work at school in order to facilitate the teaching and learning of languages. The second part of the paper is devoted to activities and tasks presented during the 10th International Conference of the EDiLiC Association. They include an awakening to languages activity, conducted as part of the Plurilingual and Pluricultural Education course at the Centre, and tasks used during the Integrated Language Didactics course for pre-service teachers of English and German or English and French.
Le matériel didactique dans le projet MEMO : développer les compétences plurilingues dans et pour l’apprentissage du français
Authors: Grimm-Pfefferli Linda , Morkötter Steffi , Schröder-Sura Anna 
Published: December 2024

La didactique du plurilinguisme permet un apprentissage approfondi des langues et offre de nombreuses possibilités de soutenir non seulement le développement des répertoires linguistiques et culturels individuels des apprenant·e·s, mais aussi de les utiliser de façon effective et systématique pour l’apprentissage d’une nouvelle langue. Dans notre contribution, il s’agit de présenter des matériaux de didactique du plurilinguisme développés pour le niveau A1 débutant du français en tant que deuxième langue étrangère après l’anglais pour les niveaux primaire, secondaire I et secondaire II. Ce matériel est le fruit d’une collaboration entre des partenaires de quatre pays germanophones dans le cadre d’un projet Erasmus+ intitulé « Modules pour promouvoir le plurilinguisme dans l’enseignement des langues étrangères (MEMO) – Exemples pour un enseignement initial du français sensible aux langues et cultures ». Par-delà les extraits de matériaux didactiques, nous exposerons les idées de base du projet ainsi que la méthodologie pour le développement des modules. Le projet s’inscrit dans la perspective ouverte par les approches plurielles des langues et des cultures et tire profit des descripteurs du CARAP (Cadre de Référence pour les approches plurielles des langues et des cultures) pour définir les compétences visées par les matériaux.
Клинико-фармакологические подходы к применению антиоксидантной терапии при мужском бесплодии
Authors: О.В. Жукова , Е.В. Ших 
Published: December 2024

Мужской фактор служит причиной бесплодия в 24% случаев, причем в 23% наблюдений регистрируются отклонения в анализе спермы. В настоящее время многие исследователи указывают на прогрессирующее снижение качества спермы у мужчин. В последние годы активно обсуждается роль оксидативного стресса в патогенезе мужского бесплодия. Оксидативный стресс, обусловленный высоким содержанием активных форм кислорода (АФК), наблюдается у 30–80% бесплодных пациентов. Сперматозоиды уязвимы для оксидативного стресса, поскольку не обладают необходимыми цитоплазматическими антиоксидантными системами восстановления, их мембрана богата полиненасыщенными жирными кислотами, что делает их восприимчивыми к перекисному окислению липидов, индуцированному оксидативным стрессом. В семенной плазме содержатся защитные факторы. Поэтому с АФК и свободными радикалами можно бороться, применяя антиоксидантную терапию. Установлено, что при совместном применении антиоксиданты проявляют синергические эффекты, что обусловливает эффективность антиоксидантных комплексов в лечении мужского бесплодия. Целесообразно сочетание в комплексе прямых и митохондриальных антиоксидантов. Митохондрии представляют собой источник энергии, являются ключевыми органеллами для подвижности сперматозоидов, акросомальной реакции и оплодотворения. Комплексная антиоксидантная терапия при оксидативном стрессе в первую очередь влияет на подвижность и концентрацию сперматозоидов, что повышает шансы на возможность наступления естественной беременности. В то же время она практически не влияет на морфологию сперматозоидов.
The male factor is the cause of infertility in 24% of cases, with abnormalities in sperm analysis recorded in 23% of cases. Currently, many studies indicate a progressive decline in sperm quality in men. In recent years, the role of oxidative stress in the pathogenesis of male infertility has been actively discussed. Oxidative stress caused by high levels of reactive oxygen species (ROS) is observed in 30–80% of infertile patients. Spermatozoa are vulnerable to oxidative stress because they do not have the necessary cytoplasmic antioxidant recovery systems, their membrane is rich in polyunsaturated fatty acids, which makes them susceptible to lipid peroxidation induced by oxidative stress. Seminal plasma contains protective factors. Therefore, ROS and free radicals can be combated using antioxidant therapy. It has been established that when used together, antioxidants exhibit synergistic effects, which makes antioxidant complexes an effective means of treating male infertility. It is advisable to combine direct and mitochondrial antioxidants in a complex. Mitochondria are a source of energy, are key organelles for sperm motility, acrosomal reaction and fertilization. Complex antioxidant therapy for oxidative stress primarily affects sperm motility and concentration, which increases the chances of natural pregnancy. At the same time, it has virtually no effect on sperm morphology.
Оценка эффективности ферментативных препаратов при лечении хронического простатита
Authors: Е.А. Яковец , Р.Э. Гилязитдинов 
Published: December 2024

Хронический простатит, или синдром хронической тазовой боли (СХТБ), представляет актуальную проблему современной урологии. СХТБ сопровождается разнообразными симптомами со стороны нижних мочевых путей, психосоциальными отклонениями и сексуальными нарушениями. Распространенность заболевания варьирует в широком диапазоне – от 2,2 до 41,2%, поэтому необходимо правильно диагностировать его причину для назначения своевременной этиотропной терапии. По данным нескольких исследований, типичные для бактериальных простатитов микроорганизмы образуют биопленки, что приводит к недостаточной диагностике и неэффективности лечения. Доказано, что применение ферментативных препаратов способствует высвобождению микроорганизмов из состава биопленок и увеличивает эффективность антибиотикотерапии. В статье представлены результаты исследования, проведенного с целью оценить эффективность ферментативных препаратов Лонгидаза и Вобэнзим в лечении хронического бактериального простатита. Показано, что использование протеолитических ферментов способствует повышению качества диагностики и эффективности лечения пациентов с хроническим простатитом.
Chronic prostatitis, or chronic pelvic pain syndrome (CPPS), is a pressing problem in modern urology. CPPS is accompanied by various lower urinary tract symptoms, psychosocial abnormalities, and sexual dysfunction. The prevalence of the disease varies widely – from 2.2 to 41.2%, so it is necessary to correctly diagnose its cause to prescribe timely etiotropic therapy. According to several studies, microorganisms typical of bacterial prostatitis form biofilms, which leads to insufficient diagnostics and ineffective treatment. It has been proven that the use of enzymatic preparations promotes the release of microorganisms from biofilms and increases the effectiveness of antibiotic therapy. The article presents the results of a study conducted to evaluate the effectiveness of enzymatic preparations Longidaza and Wobenzym in the treatment of chronic bacterial prostatitis. It has been shown that the use of proteolytic enzymes improves the quality of diagnosis and the effectiveness of treatment of patients with chronic prostatitis.
Risk Profile: Imported Eggs and Egg Products
Authors: Amanatidou Elli , Kane Catherine , Au Kaman , Hargreaves Jacob , Stoneley Amelia , Simitdjioglu Djeren , Thomas Chloe L , James Marianne , Neill Amy 
Published: December 2024

This risk profile identifies and characterises the primary hazards associated with shell eggs and egg products (EEPs) imported into the United Kingdom (UK) from domestic poultry species. The scope includes liquid, dry, cooked, and preserved egg products, excluding composite foods containing eggs or egg products. The document aims to provide essential background information on food safety concerns related to imported EEPs, support the assessment of market access requests for exporting EEPs to the UK, and assist in audit and assurance activities for EEP imports. A comprehensive literature review and analysis of incident and alert data identified over 100 potential hazards in eggs. Through expert judgement and inclusion criteria, 22 key hazards were shortlisted for characterisation. The microbiological hazards characterised include Campylobacter spp., Listeria monocytogenes, and non-typhoidal Salmonella (Salmonella Enteritidis and Salmonella Typhimurium), with Salmonella Enteritidis being the most frequently reported hazard. Chemical hazards characterised include agricultural contaminants (aflatoxins, ochratoxin A, pyrrolizidine alkaloids), biocides (fipronil, chlorate), environmental contaminants (persistent organic pollutants, melamine, metals), and various pesticides, veterinary medicinal products, and feed additives. Risk factors for microbiological hazards include hygiene and biosecurity failures, flock age and size, and environmental conditions. Chemical hazards are linked to environmental exposure and misuse of substances. Mitigation measures for microbiological hazards include eradication and vaccination programmes, while chemical hazard mitigation focuses on environmental controls and monitoring programmes. Regulatory measures in Great Britain and Northern Ireland are in place to control both chemical and microbiological hazards in eggs. This risk profile supports the Department for Environment, Food and Rural Affairs (DEFRA) and the Food Standards Agency (FSA) in ensuring the safety of imported EEPs and guiding market access and audit activities.
COMPREHENSIVE FRAMEWORK FOR REHABILITATION: SOCIAL, LEGAL, AND ECONOMIC PERSPECTIVES IN INDONESIA
Authors: Sumarno Setyo 
Published: December 2024

The book:
COMPREHENSIVE FRAMEWORK FOR REHABILITATION: SOCIAL, LEGAL, AND ECONOMIC PERSPECTIVES IN INDONESIA
ISBN 978-630-95064-0-5
is published in Technium Books.Authors full list:
Setyo Sumarno, Mu’man Nuryana, Nurhayu, Togiaratua Nainggolan, Achmadi Jayaputra, Sugiyanto, Ruaida Murni, Ery Agus Kurnianto, Himawan Estu Bagijo, Sulistyani Eka Lestari, Mohamad Miftah, Asriani, Herrukmi Septa Rinawati, Andjar Prasetyo, Andi Tenri Awaru, Husnah Rahman, Hasniati
The policy of the “100% digital court” and the principles of procedural speed and access to justice: an overview of rondônia state justice court.
Authors: Castro Souza Cássio Bruno , Montes Gregory 
Published: December 2024

The current study analyzes the “100% Digital Court” institutional policy promoted by the National Council of Justice, as a tool to impact the processing time of lawsuits in the Special Civil Courts of the Porto Velho region between 2021 and 2022, in order to check if it brought economy, speed and expansion of access to justice for those under jurisdiction, as well as if the principle of reasonable duration of the process has been observed. In view of this, innovation and technology applied to the Judiciary were analyzed, especially regarding the content of the sixth renewal wave of access to justice. Regarding the approach, deductive methodology was used for this work, given that the 100% Digital Judgment was analyzed focusing on the principles of reasonable duration of the process and access to justice and its repercussion in the Special Civil Courts of the district of Porto Velho. Regarding the procedure, the research used qualitative and quantitative methods.