bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jurassic location of the Yukon-Tanana Terrane from paleomagnetism of the folded Mississippian Tatlmain Batholith and Ragged Stock
Authors: Symons D T A , Kawasaki K 
Published: September 2019

Summary
The extensive Yukon-Tanana terrane of the northern Canadian Cordillera has been considered controversially to be part of the allochthonous ‘Baja B.C.’ microcontinent or of the para-autochthonous North American cratonic margin during the Mesozoic. Paleomagnetic methods have isolated a very-stable Early Jurassic thermochemical remanent remagnetization in the terrane's felsic Tatlmain batholith and mafic Ragged stock after correction for: 1) rotation from northeast-plunging anticlinal deformation; 2) northerly dipping tectonic tilt of the host rocks; and, 3) northwestward regional translation on the adjacent Tintina transcurrent fault zone. The resulting 196 ± 6 Ma Tatlmain and Ragged paleopoles are 64.9° N, 44.8° E (A95 = 5.9°) and 64.2° N, 58.5° E (A95 = 7.7°), respectively. The YTT paleopoles support para-autochthonous tectonic models that have the YTT: 1) accreting to North America by the Early Jurassic; 2) undergoing non-significant orogen-perpendicular shortening by mid-Early Cretaceous from thrust-faulting; and, then 3) undergoing significant orogen-parallel northward translation of ∼500 km from mid-Early Cretaceous to the Eocene. In contrast, the paleopoles for Stikinia and Quesnellia of the Intermontane Belt show progressive northwestward translation relative to North America by ∼1000 km and a rotation of ∼55° cw since mid-Early Cretaceous. We speculate that ∼500 km of the northward translation is related to dextral motion on the Tintina and Northern Rocky Mountain Trench fault in British Columbia, and that the clockwise rotation is related to upper crustal tectonics in both Yukon and southern British Columbia.
Estimation of frictional properties and slip evolution on a long-term slow slip event fault with the ensemble Kalman filter: numerical experiments
Authors: Hirahara Kazuro , Nishikiori Kento 
Published: September 2019

SummaryA variety of slow slip events at subduction zones have been observed. They can be stress meters for monitoring the stress state of megathrust faults during their earthquake cycles. In this study, we focus on long-term slow slip events (LSSEs) recurring at downdip portions of megathrust faults among such slow earthquakes. Data analyses and simulation studies of LSSEs have so far been executed independently. In atmosphere and ocean sciences, data assimilations that optimally combine data analyses and simulation studies have been developed. We develop a method for estimating frictional properties and monitoring slip evolution on an LSSE fault, with a sequential data assimilation method, the ensemble Kalman filter (EnKF). We executed numerical twin experiments for the Bungo Channel LSSE fault in southwest Japan to validate the method. First, based on a rate- and state-dependent friction law, we set a rate-weakening circular LSSE patch on the rate-strengthening flat plate interface, whose critical nucleation size is larger than that of the patch, and reproduced the observed Bungo Channel LSSEs with recurrence times of approximately 7 yr and slip durations of 1 yr. Then, we synthesized the observed data of surface displacement rates at uniformly distributed stations with noises from the simulated slip model. Using our EnKF method, we successfully estimated the frictional parameters and the slip rate evolution after a few cycles. Secondly, we considered the effect of the megathrust fault existing in the updip portion of the LSSE fault, as revealed by kinematic inversion studies of Global Navigation Satellite System (GNSS) data and added this locked region with a slip deficit rate in the model. We estimated the slip rate on the locked region only kinematically, but the quasi-dynamic equation of motion in each LSSE fault cell includes the stress term arising from the locked region. Based on this model, we synthesized the observed surface displacement rate data for the actual distribution of GNSS stations and executed EnKF estimations including the slip rate on the locked region. The slip rate on the locked region could be quickly retrieved. Even for the actual distribution of GNSS stations, we could successfully estimate frictional parameters and slip evolution on the LSSE fault. Thus, our twin numerical experiments showed the validity of our EnKF method, although we need further studies for actual GNSS data analyses.
Analysis of random walks on a hexagonal lattice
Authors: Di Crescenzo Antonio , Macci Claudio , Martinucci Barbara , Spina Serena 
Published: September 2019

Abstract
We consider a discrete-time random walk on the nodes of an unbounded hexagonal lattice. We determine the probability generating functions, the transition probabilities and the relevant moments. The convergence of the stochastic process to a two-dimensional Brownian motion is also discussed. Furthermore, we obtain some results on its asymptotic behaviour making use of large deviation theory. Finally, we investigate the first-passage-time problem of the random walk through a vertical straight line. Under suitable symmetry assumptions, we are able to determine the first-passage-time probabilities in a closed form, which deserve interest in applied fields.
Tedizolid is a promising antimicrobial option for the treatment of Staphylococcus aureus infections in cystic fibrosis patients
Authors: Roch Melanie , Varela Maria Celeste , Taglialegna Agustina , Rosato Adriana E 
Published: September 2019

Abstract

Background
Tedizolid is a protein synthesis inhibitor in clinical use for the treatment of Gram-positive infections. Pulmonary MRSA infections are a growing problem in patients with cystic fibrosis (CF) and the efficacy of tedizolid-based therapy in CF pulmonary infections is unknown.

Objectives
To evaluate the in vitro and in vivo activity of tedizolid and predict the likelihood of tedizolid resistance selection in CF-background Staphylococcus aureus strains.

Methods
A collection of 330 S. aureus strains (from adult and paediatric patients), either of normal or small colony variant (SCV) phenotypes, gathered at three CF centres in the USA was used. Tedizolid activity was assessed by broth microdilution, Etest and time–kill analysis. In vivo tedizolid efficacy was tested in a murine pneumonia model. Tedizolid in vitro mutants were obtained by 40 days of exposure and progressive passages. Whole genome sequencing of clinical S. aureus strains with reduced susceptibility to tedizolid was performed.

Results
MRSA strain MIC90s were tedizolid 0.12–0.25 mg/L and linezolid 1–2 mg/L; for MSSA strains, MIC90s were tedizolid 0.12 mg/L and linezolid 1–2 mg/L. Two strains, WIS 441 and Seattle 106, with tedizolid MICs of 2 mg/L and 1 mg/L, respectively, had MICs above the FDA tedizolid breakpoint (0.5 mg/L). Tedizolid at free serum concentrations exhibited a bacteriostatic effect. Mean bacterial burdens in lungs (log10 cfu/g) for WIS 423-infected mice were: control, 11.2±0.5; tedizolid-treated (10 mg/kg), 3.40±1.87; linezolid-treated (40 mg/kg), 4.51±2.1; and vancomycin-treated (30 mg/kg), 5.21±1.93. For WIS 441-infected mice the (log10 cfu/g) values were: control, 9.66±0.8; tedizolid-treated, 3.18±1.35; linezolid-treated 5.94±2.19; and vancomycin-treated, 4.35±1.7.

Conclusions
These results suggest that tedizolid represents a promising therapeutic option for the treatment of CF-associated MRSA/MSSA infections, having potent in vivo activity and low resistance potential.
Gaussian beam velocity tomography based on azimuth-opening angle domain common imaging gathers
Authors: Cai Jiexiong , Zheng Hao 
Published: September 2019

Abstract
Ray-based tomography in the imaging domain, implemented with seismic migration, is currently widely used in industrial applications. However, conventional ray-based tomography has some inherent problems, such as shadow area, multi-path problem and so on, which limit the inversion accuracy. To alleviate these problems, we proposed Gaussian beam velocity tomography (GBT) based on azimuth-opening angle domain common imaging gathers (ADCIGs). According to the first-order Born and Rytov approximations, we derived a linear relationship between travel-time perturbation and velocity perturbation in the imaging domain, by which we construct the explicit expression of the sensitivity kernel function and use a Gaussian beam operator to compute the kernel. Furthermore, by introducing the preconditioned model regularization, a method of GBT under the constraint of a structure-guided filter is derived. Iterative applications of migration and tomography, both based on a Gaussian beam propagator, embody the idea of integrating velocity inversion and imaging. Numerical tests on both synthetic data and field data demonstrate that Gaussian beam propagator-based travel-time tomography in the imaging domain is effective.
Reducing West Nile Virus Risk Through Vector Management
Authors: Nasci Roger S , Mutebi John-Paul 
Published: September 2019

Abstract
Over 50,000 human West Nile virus (WNV) (Flaviviridae: Flavivirus) clinical disease cases have been reported to the CDC during the 20 yr that the virus has been present in the United States. Despite the establishment and expansion of WNV-focused mosquito surveillance and control efforts and a renewed emphasis on applying integrated pest management (IPM) principles to WNV control, periodic local and regional WNV epidemics with case reports exceeding 2,000 cases per year have occurred during 13 of those 20 yr in the United States. In this article, we examine the scientific literature for evidence that mosquito control activities directed at either preventing WNV outbreaks or stopping those outbreaks once in progress reduce WNV human disease or have a measurable impact on entomological indicators of human WNV risk. We found that, despite a proliferation of research investigating larval and adult mosquito control effectiveness, few of these studies actually measure epidemiological outcomes or the entomological surrogates of WNV risk. Although many IPM principles (e.g., control decisions based on surveillance, use of multiple control methodologies appropriate for the ecosystem) have been implemented effectively, the use of action thresholds or meaningful public health outcome assessments have not been used routinely. Establishing thresholds for entomological indicators of human risk analogous to the economic injury level and economic thresholds utilized in crop IPM programs may result in more effective WNV prevention.
Simulation of Chemotherapy Effects in Older Breast Cancer Patients With High Recurrence Scores
Authors: Chandler Young , Jayasekera Jinani C , Schechter Clyde B , Isaacs Claudine , Cadham Christopher J , Mandelblatt Jeanne S 
Published: September 2019

Abstract

Background
Tumor genomic expression profile data are used to guide chemotherapy choice, but there are gaps in evidence for women aged 65 years and older. We estimate chemotherapy effects by age and comorbidity level among women with early-stage, hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancers and Oncotype DX scores of 26 or higher.

Methods
A discrete-time stochastic state transition simulation model synthesized data from population studies and clinical trials to estimate outcomes over a 25-year horizon for subgroups based on age (65–69, 70–74, 75–79, and 80–89 years) and comorbidity levels (no or low, moderate, severe). Outcomes were discounted at 3%, and included quality-adjusted life-years (QALYs), life-years, and breast cancer and other-cause mortality with chemoendocrine vs endocrine therapy. Sensitivity analysis tested the effect of varying uncertain parameters.

Results
Women aged 65–69 years with no or low comorbidity gained 0.16 QALYs with chemo-endocrine and reduced breast cancer mortality from 34.8% to 29.7%, for an absolute difference of 5.1%; this benefit was associated with a 12.8% rate of grade 3–4 toxicity. Women aged 65–69 years with no or low or moderate comorbidity levels, and women aged 70–74 years with no or low comorbidity had small chemotherapy benefits. All women aged 75 years and older experienced net losses in QALYs with chemo-endocrine therapy. The results were robust in sensitivity analyses. Chemotherapy had greater benefits as treatment effectiveness increased, but toxicity reduced the QALYs gained.

Conclusion
Among women aged 65–89 years whose tumors indicate a high recurrence risk, only those aged 65–74 years with no or low or moderate comorbidity have small benefits from adding chemotherapy to endocrine therapy. Genomic expression profile testing (and chemotherapy use) should be reserved for women aged younger than 75 years without severe comorbidity.
Long-term variability of a black widow’s eclipses – A decade of PSR J2051$-$0827
Authors: Polzin E J , Breton R P , Stappers B W , Bhattacharyya B , Janssen G H , Osłowski S , Roberts M S E , Sobey C 
Published: September 2019

ABSTRACT
In this paper we report on $\sim 10$  yr of observations of PSR J2051$-$0827, at radio frequencies in the range 110–4032 MHz. We investigate the eclipse phenomena of this black widow pulsar using model fits of increased dispersion and scattering of the pulsed radio emission as it traverses the eclipse medium. These model fits reveal variability in dispersion features on time-scales as short as the orbital period, and previously unknown trends on time-scales of months–years. No clear patterns are found between the low-frequency eclipse widths, orbital period variations, and trends in the intrabinary material density. Using polarization calibrated observations we present the first available limits on the strength of magnetic fields within the eclipse region of this system; the average line of sight field is constrained to be $10^{-4}$ G $\lesssim B_{||} \lesssim 10^2$ G, while for the case of a field directed near-perpendicular to the line of sight we find $B_{\perp } \lesssim 0.3$ G. Depolarization of the linearly polarized pulses during the eclipse is detected and attributed to rapid rotation measure fluctuations of $\sigma _{\text{RM}} \gtrsim 100$ rad m$^{-2}$ along, or across, the line of sights averaged over during a subintegration. The results are considered in the context of eclipse mechanisms, and we find scattering and/or cyclotron absorption provide the most promising explanation, while dispersion smearing is conclusively ruled out. Finally, we estimate the mass-loss rate from the companion to be $\dot{M}_{\text{C}} \sim 10^{-12}\, \mathrm{M}_\odot$ yr$^{-1}$, suggesting that the companion will not be fully evaporated on any reasonable time-scale
Hypertrophic Interstitial Neuropathy of the Trigeminal Nerve: Case Report and Literature Review
Authors: Wang Alick P , Catana Dragos , Provias John P , Reddy Kesava K V 
Published: September 2019

Abstract

BACKGROUND AND IMPORTANCE
Hypertrophic interstitial neuropathy (HIN) is an uncommon, non-neoplastic lesion typically affecting peripheral nerves. Cranial nerve (CN) involvement is exceedingly rare. We present a case of isolated trigeminal nerve HIN manifesting with V3 distribution neuralgia.

CLINICAL PRESENTATION
A 50-yr-old male presented with left sided trigeminal neuralgia refractory to medical management. The patient underwent retromastoid craniectomy for possible microvascular decompression. Intra-operatively, the trigeminal nerve appeared to be focally enlarged with a sausage-like configuration. We selectively resected 1 fascicle which was predominantly involved. Histopathological examination revealed onion bulb formations composed of Schwann cells around centrally placed axons. A diagnosis of HIN was made. Postoperatively, the patient experienced complete resolution of symptoms.

CONCLUSION
This is the third case of isolated trigeminal nerve HIN in the literature. We performed a selective resection in a patient presenting with trigeminal neuralgia, resulting in complete resolution of symptoms. It is reported here with intraoperative microscope images, along with a review and analysis of this topic as it related to CN.
Fermion mass and mixing in a low-scale seesaw model based on the S4 flavor symmetry
Authors: Vien V V , Long H N , Hernández A E Cárcamo 
Published: September 2019

Abstract
We construct a low-scale seesaw model to generate the masses of active neutrinos based on $S_4$ flavor symmetry supplemented by the $Z_2 \times Z_3 \times Z_4 \times Z_{14}\times U(1)_L$ group, capable of reproducing the low-energy Standard Model (SM) fermion flavor data. The masses of the SM fermions and the fermionic mixing parameters are generated from a Froggatt–Nielsen mechanism after spontaneous breaking of the $S_4\times Z_2 \times Z_3 \times Z_4 \times Z_{14}\times U(1)_L$ group. The obtained values for the physical observables of the quark and lepton sectors are in good agreement with the most recent experimental data. The leptonic Dirac CP-violating phase $\delta _\mathrm{CP}$ is predicted to be $259.579^\circ$ and the predictions for the absolute neutrino masses in the model can also saturate the recent constraints.
Oscillopsia in Bilateral Vestibular Hypofunction: Not Only Gain But Saccades Too
Authors: Batuecas-Caletrio Angel , Trinidad-Ruiz Gabriel , Rey-Martinez Jorge , Matiño-Soler Eusebi , Martin Sanz Eduardo , Perez Fernandez Nicolás 
Published: September 2019

Objectives:
Oscillopsia is a disabling condition for patients with bilateral vestibular hypofunction (BVH). When the vestibulo-ocular reflex is bilaterally impaired, its ability to compensate for rapid head movements must be supported by refixation saccades. The objective of this study is to assess the relationship between saccadic strategies and perceived oscillopsia.

Design:
To avoid the possibility of bias due to remaining vestibular function, we classified patients into two groups according to their gain values in the video head impulse test. One group comprised patients with extremely low gain (0.2 or below) in both sides, and a control group contained BVH patients with gain between 0.2 and 0.6 bilaterally. Binary logistic regression (BLR) was used to determine the variables predicting oscillopsia.

Results:
Twenty-nine patients were assigned to the extremely low gain group and 23 to the control group. The BLR model revealed the PR score (saccades synchrony measurement) to be the best predictor of oscillopsia. Receiver operating characteristic analysis determined that the most efficient cutoff point for the probabilities saved with the BLR was 0.518, yielding a sensitivity of 86.6% and specificity of 84.2%.

Conclusions:
BVH patients with higher PR values (nonsynchronized saccades) were more prone to oscillopsia independent of their gain values. We suggest that the PR score can be considered a useful measurement of compensation.
Impact of Prolonged Skeletal Traction in Patients With Acetabular Fractures
Authors: Boissonneault Adam R. , Schenker Mara , Wilson Jake , Schwartz Andrew , Staley Christopher , Maceroli Michael 
Published: September 2019

Objectives:
To explore the association between increased time in traction and in-hospital pulmonary complications in patients with acetabular fractures.

Design:
Retrospective.

Setting:
Level I trauma center.

Patients/Participants:
One hundred ninety consecutive patients.

Intervention:
Application of skeletal traction before fixation of acetabular fracture.

Main Outcome Measurements:
The primary outcome measure was pulmonary complication as defined by pulmonary embolism, pneumonia, and acute respiratory distress syndrome. Secondary outcome measures included length of intensive care unit stay (in days), total length of hospital stay (in days), deep hardware-associated infection, subsequent conversion to total hip arthroplasty, urinary tract infection, and lower-extremity deep venous thrombosis.

Results:
The mean time in traction for patients who developed a pulmonary complication was 210 hours compared with 62 hours for those who did not (P < 0.001). After controlling for Injury Severity Score, chest injury, and concomitant long bone injury requiring intramedullary nailing, the odds of developing a pulmonary complication for patients who spent longer than 120 hours in traction were over 40 times higher than those treated within 5 days (P < 0.001). The mean intensive care unit stay for patients who spent at least 120 hours in traction was 17 days compared with 5 days for those treated in less than 120 hours (P < 0.001).

Conclusion:
Early definitive fixation and decreased time in skeletal traction is associated with a lower rate of complications in patients with acetabular fractures. Our results would suggest that fixation of acetabular fractures before 120 hours (5 days) confers a significant risk-reduction benefit.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Feasibility of Hidden Markov Models for the Description of Time-Varying Physiologic State After Severe Traumatic Brain Injury
Authors: Asgari Shadnaz , Adams Hadie , Kasprowicz Magdalena , Czosnyka Marek , Smielewski Peter , Ercole Ari 
Published: September 2019

Objectives:
Continuous assessment of physiology after traumatic brain injury is essential to prevent secondary brain insults. The present work aims at the development of a method for detecting physiologic states associated with the outcome from time-series physiologic measurements using a hidden Markov model.

Design:
Unsupervised clustering of hourly values of intracranial pressure/cerebral perfusion pressure, the compensatory reserve index, and autoregulation status was attempted using a hidden Markov model. A ternary state variable was learned to classify the patient’s physiologic state at any point in time into three categories (“good,” “intermediate,” or “poor”) and determined the physiologic parameters associated with each state.

Setting:
The proposed hidden Markov model was trained and applied on a large dataset (28,939 hr of data) using a stratified 20-fold cross-validation.

Patients:
The data were collected from 379 traumatic brain injury patients admitted to Addenbrooke’s Hospital, Cambridge between 2002 and 2016.

Interventions:
Retrospective observational analysis.

Measurements and Main Results:
Unsupervised training of the hidden Markov model yielded states characterized by intracranial pressure, cerebral perfusion pressure, compensatory reserve index, and autoregulation status that were physiologically plausible. The resulting classifier retained a dose-dependent prognostic ability. Dynamic analysis suggested that the hidden Markov model was stable over short periods of time consistent with typical timescales for traumatic brain injury pathogenesis.

Conclusions:
To our knowledge, this is the first application of unsupervised learning to multidimensional time-series traumatic brain injury physiology. We demonstrated that clustering using a hidden Markov model can reduce a complex set of physiologic variables to a simple sequence of clinically plausible time-sensitive physiologic states while retaining prognostic information in a dose-dependent manner. Such states may provide a more natural and parsimonious basis for triggering intervention decisions.