bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic panniculitis in active systemic lupus erythematosus
Authors: Goyal Amrita , Jain Meera , Rehberg Kim , Goodman Warren , Gertner Elie 
Published: May 2019

AbstractThis report documents the case of a 64‐year‐old African‐American female with new end‐stage renal disease (ESRD), diagnosed with systemic lupus erythematosus (SLE) on renal biopsy and serologies including a positive ANA (>1:2560), positive anti‐Sm antibodies, low titer anti‐RNP antibodies, high titer anti‐Ro antibodies, anti‐dsDNA antibodies, lupus anticoagulant, and hypocomplementemia. She was also noted to have tender nodules on the bilateral shins. Excisional biopsy of one of the nodules showed marked fat necrosis with “ghost cells” and patchy basophilic granular debris consistent with pancreatic panniculitis. Further examination for pancreatic pathology showed an elevated lipase of 585 U/L (reference range 8‐78 U/L) and amylase of 214 U/L (reference range 25‐125 U/L). However, computed tomography imaging showed no evidence of pancreatitis or pancreatic tumors. This is very similar to another case recently reported in the literature. Similarities of these two cases (African‐American females with lupus nephritis on dialysis) may represent a particular subset of SLE patients at increased risk for pancreatic panniculitis.
Community‐based program promotes interprofessional collaboration among home healthcare professionals: A non‐randomized controlled study
Authors: Noguchi‐Watanabe Maiko , Maruyama‐Sakurai Keiko , Yamamoto‐Mitani Noriko , Matsumoto Yoshiko , Yoshie Satoru , Iijima Katsuya , Yamanaka Takashi , Akishita Masahiro 
Published: May 2019

AimTo evaluate the effect of an interprofessional collaboration (IPC) promotion program among community healthcare professionals.MethodsA non‐randomized controlled study was carried out. Study participants were home healthcare‐related professionals in a suburban city near Tokyo; program participants were compared with non‐participants. The program consisted of two workshops each 2 h long and 4 months apart. The first workshop focused on developing a community resource map, and discussing community strengths and features. The second focused on examining a case of transitional care from hospital to home. Mail surveys were carried out before the first workshop and 6 months after. The IPC level was examined using an established seven‐domain scale. Analysis of covariance was used to examine the program effect by comparing baseline and 6‐month data in the two groups.ResultsAltogether, 213 professionals participated (intervention: n = 141 vs control: n = 72); approximately 60% were women, with a mean age of 45.9 ± 10.2 years. There were significant between‐group differences in baseline IPC score, age, type of profession and number of other educational opportunities. After adjusting for these variables, the IPC domains of “familiarity” and “meeting and talking” improved significantly in the intervention group as compared with the control group (P = 0.011 and 0.036, respectively). When the intervention group was split in two (two‐time vs one‐time participants), the improvement at 6 months was not significantly different between two‐ and one‐time participants.ConclusionsIt is suggested that our program is effective to improve the IPC level; one‐time participation might be enough to have expected improvement. Geriatr Gerontol Int 2019; 19: 660–666.
Liver transplantation in Japan: Registry by the Japanese Liver Transplantation Society
Authors: Umeshita Koji , Eguchi Susumu , Egawa Hiroto , Haga Hironori , Kasahara Mureo , Kokudo Norihiro , Sakisaka Shotaro , Takada Yasutsugu , Tanaka Eiji , Eguchi Hidetoshi , Uemoto Shinji , Ohdan Hideki 
Published: May 2019

As of 31 December 2017, a total of 9242 liver transplants have been carried out in 67 institutions in Japan. There were 447 deceased donor transplants (444 from heart‐beating donors and 3 from non‐heart‐beating donors) and 8795 living‐donor transplants. The annual total of liver transplants in 2017 was 416 (69 deceased donor transplants and 347 living‐donor transplants). The most frequent indication was cholestatic disease, followed by neoplastic disease and hepatocellular disease. In terms of hepatocellular disease in 2017, cirrhosis due to hepatitis C and B decreased (13 and 8, respectively), whereas alcoholic cirrhosis markedly increased (32). Patient survival following transplantation from heart‐beating donor (444 transplants: 1 year, 89.1%; 3 years, 85.2%; 5 years, 82.9%; 10 years, 75.4%; 15 years, 70.7%) was similar to that from living‐donor (8794 transplants: 1 year, 85.0%; 3 years, 80.9%; 5 years, 78.5%; 10 years, 73.2%; 15 years, 68.5%; 20 years, 65.7%; 25 years, 64.6%). Graft survival was very much the same as patient survival (heart‐beating donor: 1 year, 88.4%; 3 years, 84.5%; 5 years, 82.2%; 10 years, 74.7%; 15 years, 70.1%; living donor: 1 year, 84.3%; 3 years, 79.9%; 5 years, 77.3%; 10 years, 71.4%; 15 years, 66.3%; 20 years, 63.3%; 25 years, 61.9%). Survival data are reported according to age and sex of recipient, indication, age and sex of donor, ABO compatibility, and other factors.
Are general practitioners getting the information they need from hospitals and specialists to provide quality cancer care for Indigenous Australians?
Authors: Valery Patricia C. , Bernardes Christina M. , de Witt Audra , Martin Jennifer , Walpole Euan , Garvey Gail , Williamson Daniel , Meiklejohn Judith , Hartel Gunter , Ratnasekera Isanka U. , Bailie Ross 
Published: May 2019

AbstractBackgroundCancer care involves many different healthcare providers. Delayed or inaccurate communication between specialists and general practitioners (GP) may negatively affect care.AimTo describe the pattern and variation of communication between primary healthcare (PHC) services and hospitals and specialists in relation to the patient's cancer care.MethodsA retrospective audit of clinical records of Indigenous Australians diagnosed with cancer during 2010–2016 identified through 10 PHC services in Queensland is described. Poisson regression was used to model the dichotomous outcome availability of hospital discharge summary versus not.ResultsA total of 138 patient records was audited; 115 of those patients visited the PHC service for cancer‐related care after cancer diagnosis; 40.0% visited the service before a discharge summary was available, and 36.5% of the patients had no discharge summary in their medical notes. While most discharge summaries noted important information about the patient's cancer, 42.4% lacked details regarding the discharge medications regimen.ConclusionsDeficits in communication and information transfer between specialists and GP may adversely affect patient care. Indigenous Australians are a relatively disadvantaged group that experience poor health outcomes and relatively poor access to care. The low proportion of discharge summaries noting discharge medication regimen is of concern among Indigenous Australians with cancer who have high comorbidity burden and low health literacy. Our findings provide an insight into some of the factors associated with quality of cancer care, and may provide guidance for focus areas for further research and improvement efforts.
Histone deacetylase inhibitor treatment promotes spontaneous caregiving behaviour in non‐aggressive virgin male mice
Authors: Mayer Heather S. , Crepeau Marc , Duque‐Wilckens Natalia , Torres Lisette Y. , Trainor Brian C. , Stolzenberg Danielle S. 
Published: May 2019

AbstractThe majority of mammalian species are uniparental, with the mother solely providing care for young conspecifics, although fathering behaviours can emerge under certain circumstances. For example, a great deal of individual variation in response to young pups has been reported in multiple inbred strains of laboratory male mice. Furthermore, sexual experience and subsequent cohabitation with a female conspecific can induce caregiving responses in otherwise indifferent, fearful or aggressive males. Thus, a highly conserved parental neural circuit is likely present in both sexes; however, the extent to which infants are capable of activating this circuit may vary. In support of this idea, fearful or indifferent responses toward pups in female mice are linked to greater immediate early gene (IEG) expression in a fear/defensive circuit involving the anterior hypothalamus compared to that in an approach/attraction circuit involving the ventral tegmental area. However, experience with infants, particularly in combination with histone deacetylase inhibitor (HDACi) treatment, can reverse this pattern of pup‐induced activation of fear/defence circuitry and promote approach behaviour. Thus, HDACi treatment may increase the transcription of primed/poised genes that play a role in the activation and selection of a maternal approach circuit in response to pup stimuli. In the present study, we investigated whether HDACi treatment would impact behavioural response selection and associated IEG expression changes in virgin male mice that are capable of ignoring, attacking or caring for pups. The results obtained indicate that systemic HDACi treatment induces spontaneous caregiving behaviour in non‐aggressive male mice and alters the pattern of pup‐induced IEG expression across a fear/defensive neural circuit.
Development of Immigrant Couple Relations in Germany
Authors: Johnson Matthew D. , Neyer Franz J. , Anderson Jared R. 
Published: May 2019

AbstractObjective: This study investigates whether relationship satisfaction, conflict frequency, and self‐disclosure follow distinct developmental trajectories for immigrant couples when compared with native‐born couples and explores the factors that explain developmental diversity for immigrant couples.Background: Despite nearly a quarter of a billion people worldwide living in a country other than their birth country, no longitudinal research has examined immigrant couple intimate relations. Stress‐focused theoretical perspectives provide motivation for the current study.Method: Five annual waves of survey data from the German Family Panel (pairfam) study were analyzed. Propensity score matching was used to select a sample of immigrant (n = 614) and native‐born (n = 2,097) couples matched on a number of potentially confounding demographic (e.g., marital status) and values‐based (e.g., traditional gender‐role attitudes) variables.Results: Latent growth curve analyses revealed few differences between immigrant and native‐born couple trajectories and, where differences arose, the trajectories converged by Wave 5. Within immigrant couples, having both partners as immigrants emerged as a protective factor, whereas citizenship status in the receiving country and length of time since immigrating were not consistently associated with the relationship outcomes. Associations among couple supportiveness, traditional gender roles, and Big Five personality variables with the immigrant couple trajectories were consistent with findings in the relationship science literature.Conclusion: Although being an immigrant entails navigating additional challenges in daily life as a result of one's minority status, these results bear testament to the remarkable resilience of immigrant couples.
Bias: A 30‐Year Review of Randomized Controlled Trials Published in Three Prosthodontic Journals
Authors: Dumbrigue Herman B. , Dumbrigue Derek C. , Dumbrigue Ethan C. , Chingbingyong Marianne I. 
Published: May 2019

AbstractPurposeBias can occur in various phases of an investigation, and its control is an important measure of the validity of results for randomized controlled trials (RCTs). The purpose of this study is to determine if bias control in prosthodontic RCTs published from 2008 to 2017 improved over those published from 1988 to 1997.Materials and MethodsMEDLINE was searched for RCTs in The International Journal of Prosthodontics, The Journal of Prosthetic Dentistry, and The Journal of Prosthodontics published from 2008 to 2017. Citations retrieved were included if the trial involved human subjects, included at least 2 treatment groups, and group assignment was by random allocation. Pilot and follow‐up studies were excluded. Included RCTs were evaluated on the basis of how control of potential sources of bias in trial methodology were reported. Three areas—control of bias at entry, control of bias in assessment of outcome, and control of bias after entry—were scored 1 or 0, based on whether method of randomization was explicitly reported, blinding was done, and all subjects were accounted for at the end of the study. Thus, the maximum quality score was 3 (good bias control) and the minimum 0 (poor bias control). Frequencies were calculated for each dimension of trial methodology, and overall scores were reported. Results were compared to those of RCTs published from 1988 to 1997 reported in a previous study.ResultsNinety‐six RCTs published from 2008 to 2017 met the inclusion criteria and were reviewed. Method of randomization was explicit in 68% of RCTs, 50% reported blinding, and 85% accounted for all subjects; 32% scored the maximum 3 points for good bias control. In comparison, 62 RCTs published from 1988 to 1997 had frequencies of 47%, 40%, and 76% in the 3 areas examined, respectively; only 16% had maximum scores for good bias control.ConclusionControl of bias and overall quality scores have improved for RCTs published in the 3 studied prosthodontic journals.
Case Marking Variation in Heritage Slavic Languages in Toronto: Not So Different
Authors: Łyskawa Paulina , Nagy Naomi 
Published: May 2019

AbstractWe examined case‐marking variation in heritage Polish, Russian, and Ukrainian. Comparing heritage to homeland Polish and Ukrainian speakers, we found only a few types and a few tokens of systematic distinction between heritage and homeland varieties. A total of 6,291 instances of nouns and pronouns were extracted from transcribed conversations with 62 speakers. Comparing normative forms to observed forms in logistic regression analyses showed that the form of the nominal and the case selector have significant effects on the rate of match between normative and observed forms, while declension does not. Most mismatches in the heritage data were replaced by the nominative, a pattern which is also occasionally found in homeland speech. The second most frequent pattern is genitive–accusative mismatch in specific contexts, in both heritage and homeland speech. Importantly, no significant differences between homeland and heritage speakers emerged, with 8% mismatch attested in the heritage and 2% in homeland data.
Using a gender lens to understand eating behaviours of adolescent females living in low‐income households in Bangladesh
Authors: Blum Lauren S. , Khan Rasheda , Sultana Marzia , Soltana Nahian , Siddiqua Yasmin , Khondker Rudaba , Sultana Sabiha , Tumilowicz Alison 
Published: May 2019

AbstractAdolescence is a critical period characterized by rapid physical, psychological, and social development and growth. In Bangladesh, high rates of undernutrition persist among adolescent females living in low‐income households. Prevalence of adolescent marriage and pregnancy is extremely high, with almost half of Bangladeshi women giving birth by 18 years of age. Qualitative research was carried out from April to June 2017 to examine individual, social, and environmental factors influencing eating behaviours of female adolescents between 15 and 19 years of age living in low‐income families in urban and rural settings in Bangladesh. Methods included freelisting exercises (33), key informant interviews (11), in‐depth interviews (24), direct observations (16), and focus group discussions (12). Findings show that household food insecurity necessitates adjustments in meal food quality and frequency. Gender norms prescribe that females receive small meal portions and make sacrifices in food consumption so that male family members can eat more. Work and school schedules cause long breaks between meal consumption, restricting food intake of adolescent females for extended periods. Gender discrimination and its manifestations likely amplify susceptibility to psychological stresses in adolescent females. An inferior social position makes adolescent females living in food insecure households vulnerable to undernutrition, with factors affecting food deprivation increasing as they approach childbearing. Policies to increase age of marriage and reduce adolescent pregnancy must continue. Programmes must ensure that school‐going adolescents eat adequately during the school day. Prolonging school education and strengthening the economic viability of women should alter cultural expectations regarding marriage age and normative female roles.
Calcium‐phosphate product and its impact on mortality in hospitalized patients
Authors: Thongprayoon Charat , Cheungpasitporn Wisit , Mao Michael A , Erickson Stephen B 
Published: May 2019

ABSTRACTAimThis study aimed to assess the relationship between admission Calcium‐phosphate (CaP) and in‐hospital mortality in hospitalized patients.MethodsAll adult hospitalized patients who had both admission serum calcium and phosphate levels available between years 2009 and 2013 were enrolled. Admission CaP was categorized based on its distribution into six groups (<21, 21–<27, 27–<33, 33  39, 39–<45 and ≥45 mg2/dL2). Multivariate logistic regression was used to assess the association between admission CaP and in‐hospital mortality, using the CaP of 27–<33 mg2/dL2 as the reference group.ResultsAbut 14 772 patients were included in the analysis. The association between CaP and in‐hospital mortality was U‐shaped with the lowest in‐hospital mortality in CaP of 27–<33 mg2/dL2. After adjusting for potential confounders, both CaP <21 and ≥39 mg2/dL2 were associated with higher in‐hospital mortality. Subgroup analysis demonstrated that the highest in‐hospital mortality risk in both chronic kidney disease (CKD) and non‐CKD patients occurred when CaP ≥ 45 mg2/dL2.ConclusionCaP levels on admission were associated with in‐hospital mortality. Highest mortality risk was observed in hospitalized patients with admission CaP of ≥45 mg2/dL2 in both CKD and non‐CKD patients.
Contribution and consequences of xylem‐transported CO2 assimilation for C3 plants
Authors: Stutz Samantha S. , Hanson David T. 
Published: May 2019

Summary

Traditionally, leaves were thought to be supplied with CO2 for photosynthesis by the atmosphere and respiration. Recent studies, however, have shown that the xylem also transports a significant amount of inorganic carbon into leaves through the bulk flow of water. However, little is known about the dynamics and proportion of xylem‐transported CO2 that is assimilated, vs simply lost to transpiration.

Cut leaves of Populus deltoides and Brassica napus were placed in either KCl or one of three [NaH13CO3] solutions dissolved in water to simultaneously measure the assimilation and the efflux of xylem‐transported CO2 exiting the leaf across light and CO2 response curves in real‐time using a tunable diode laser absorption spectroscope.

The rates of assimilation and efflux of xylem‐transported CO2 increased with increasing xylem [13CO2*] and transpiration. Under saturating irradiance, rates of assimilation using xylem‐transported CO2 accounted for c. 2.5% of the total assimilation in both species in the highest [13CO2*].

The majority of xylem‐transported CO2 is assimilated, and efflux is small compared to respiration. Assimilation of xylem‐transported CO2 comprises a small portion of total photosynthesis, but may be more important when CO2 is limiting.
Plant proton pumping pyrophosphatase: the potential for its pyrophosphate synthesis activity to modulate plant growth
Authors: Primo C. , Pizzio G. A. , Yang J. , Gaxiola R. A. , Scholz‐Starke J. , Hirschi K. D. 
Published: May 2019

AbstractCellular pyrophosphate (PPi) homeostasis is vital for normal plant growth and development. Plant proton‐pumping pyrophosphatases (H+‐PPases) are enzymes with different tissue‐specific functions related to the regulation of PPi homeostasis. Enhanced expression of plant H+‐PPases increases biomass and yield in different crop species. Here, we emphasise emerging studies utilising heterologous expression in yeast and plant vacuole electrophysiology approaches, as well as phylogenetic relationships and structural analysis, to showcase that the H+‐PPases possess a PPi synthesis function. We postulate this synthase activity contributes to modulating and promoting plant growth both in H+‐PPase‐engineered crops and in wild‐type plants. We propose a model where the PPi synthase activity of H+‐PPases maintains the PPi pool when cells adopt PPi‐dependent glycolysis during high energy demands and/or low oxygen environments. We conclude by proposing experiments to further investigate the H+‐PPase‐mediated PPi synthase role in plant growth.
High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers
Authors: Gohir Wajiha , Kennedy Katherine M. , Wallace Jessica G. , Saoi Michelle , Bellissimo Christian J. , Britz‐McKibbin Philip , Petrik Jim J. , Surette Michael G. , Sloboda Deborah M. 
Published: May 2019

Key points
Maternal obesity has been associated with shifts in intestinal microbiota, which may contribute to impaired barrier function
Impaired barrier function may expose the placenta and fetus to pro‐inflammatory mediators
We investigated the impacts of diet‐induced obesity in mice on maternal and fetal intestinal structure and placental vascularization
Diet‐induced obesity decreased maternal intestinal short chain fatty acids and their receptors, impaired gut barrier integrity and was associated with fetal intestinal inflammation.
Placenta from obese mothers showed blood vessel immaturity, hypoxia, increased transcript levels of inflammation, autophagy and altered levels of endoplasmic reticulum stress markers.
These data suggest that maternal intestinal changes probably contribute to adverse placental adaptations and also impart an increased risk of obesity in the offspring via alterations in fetal gut development.
AbstractShifts in maternal intestinal microbiota have been implicated in metabolic adaptations to pregnancy. In the present study, we generated cohorts of female C57BL/6J mice fed a control (17% kcal fat, n = 10–14) or a high‐fat diet (HFD 60% kcal from fat, n = 10–14; ad libitum) aiming to investigate the impact on the maternal gut microbiota, intestinal inflammation and gut barrier integrity, placental inflammation and fetal intestinal development at embryonic day 18.5. HFD was associated with decreased relative abundances of short‐chain fatty acid (SCFA) producing genera during pregnancy. These diet‐induced shifts paralleled decreased maternal intestinal mRNA levels of SCFA receptor Gpr41, modestly decreased cecal butyrate, and altered mRNA levels of inflammatory cytokines and immune cell markers in the maternal intestine. Maternal HFD resulted in impaired gut barrier integrity, with corresponding increases in circulating maternal levels of lipopolysaccharide (LPS) and tumour necrosis factor. Placentas from HFD dams demonstrated blood vessel immaturity and hypoxia; decreased free carnitine, acylcarnitine derivatives and trimethylamine‐N‐oxide; and altered mRNA levels of inflammation, autophagy, and ER stress markers. HFD exposed fetuses had increased activation of nuclear factor‐kappa B and inhibition of the unfolded protein response in the developing intestine. Taken together, these data suggest that HFD intake prior to and during pregnancy shifts the composition of the maternal gut microbiota and impairs gut barrier integrity, resulting in increased maternal circulating LPS, which may ultimate contribute to changes in placental vascularization and fetal gut development.