bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of indications and route of hysterectomy for benign conditions
Authors: Patne Smita S. , Upadhye Aditi J. , Upadhye Jayshree J. 
Published: May 2018

Background: Hysterectomy is the most common operation performed by gynecologist, next to caesarean section. The primary focus of this study was to review the indications and surgical technique of hysterectomy.Methods: This retrospective study was performed in the department of Obstetrics and gynecology, in collaboration with Department of Pathology. All women in the reproductive age group and post-menopausal age who underwent hysterectomy with or without salpingo-oophorectomy were included in this study.Results: In our study, out of 100 patients, clinical indication was fibroid in 45 (45%) patients, menorrhagia in 15 (15%) patients, adenomyosis in 25 (25%) patients, uterovaginal prolapse in 5 (5%) patients, endometrial polyp in 5 (5%) patients and ovarian tumor in 5 (5%) patients. Histo-pathological diagnosis was leiomyoma in 55 (55%), adenomyosis in 30 (30%), endometrial polyp in 5 (5%), endometrial hyperplasia in 5 (5%) and serous cystadenoma of ovary in 5 (5%). Abdominal hysterectomy was performed in 46 (46%) patients, vaginal hysterectomy in 44 (44.33%) patients while laparoscopic hysterectomy was performed in 5 (6.66%) patients.Conclusions: In this study, most common indication for hysterectomy was fibroid uterus and it was correlated well with histopathology. Abdominal & vaginal hysterectomies were performed in almost equal number.
Non-descent vaginal hysterectomy in women with previous caesarean section scar: our experience
Authors: Maiti G. D. , Pillai Ashok , Jose Tony , Lele P. R. 
Published: May 2018

Background: Hysterectomy is one of the common gynaecological major surgeries performed worldwide. In spite of technological advancement with laparoscopic and robotic hysterectomy conventional hysterectomy through vaginal route of nonprolapse uterus popularly known as, Non-Descent Vaginal Hysterectomy (NDVH) remains a justifiable cost effective, cosmetically appealing option especially in resource-crunched developing country. NDVH in post caesarean scarred uterus too a technically challenged procedure requiring skills and expertise.Assessment of technical feasibility and safety of non-descent vaginal hysterectomy in women with previous caesarean section scar were studied.Methods: The study was a prospective observational study of 72 patients with LSCS scar requiring hysterectomy for benign conditions were selected based on the inclusion and exclusion criteria carried out from June 2012 to May 2017. Operating time, blood loss, surgical techniques, intra/postoperative challenges, conversion to laparotomy or laparoscopic assistance and length of hospital stay were recorded for each case. Patients were followed up till 03 months of surgery.Results: Vaginal hysterectomy was successful in all cases. Morcellation, bisection or myomectomy, were done in 86% cases. Two patients had bladder injury, which was repaired vaginally, two cases required support of laparoscopy. No patients needed blood transfusion. None of the patients were converted to laparotomy.Conclusions: Vaginal hysterectomy is a safe and effective procedure for benign non-prolapsed uteri in women with previous caesarean section scar when uterine size is less than 14 weeks. Standby operating laparoscopy provides added advantages to surgeon in doubtful or difficult cases to avoid conversion laparotomy.
Management of traumatic pneumothorax in isolated blunt chest trauma
Authors: SARIÇAM Murat , ÖZKAN Berker , TÜRK Yaşar 
Published: May 2018

Objectives: Pneumothorax
is an important complication of blunt chest trauma. The aim of this study was
to report our experience in treatment strategy and outcomes of traumatic
pneumothorax. Methods: A total of 78 patients who developed pneumothorax due
to isolated blunt chest trauma were evaluated in terms of age, gender, size of
pneumothorax, treatment methods, complications and length of hospital stay. The
size of pneumothorax was calculated with computer-aided volumetry. Results: Tube thoracostomy was performed for 48 patients while observation was
undertaken for 30 cases. Chest tubes were inserted in 6 patients after 24 hours
following the traumatic event. A total of 8 patients who developed prolonged
air leakage and hemothorax as complications underwent video-assisted
thoracoscopic surgery. None of the patients developed any mortality or
morbidity. Conclusions: Traumatic pneumothorax demands prompt diagnosis
and treatment. Monitoring all patients even with small sizes of traumatic
pneumothorax for at least 24 hours onset of their initial assessment and
applying chest tubes for cases who have pneumothorax larger than 50% at first
examination should be an appropriate modality for treatment. Moreover, the
minimally invasive approach of video-assisted thoracoscopic surgery benefits to
overcome the complications of thoracic trauma.
Under the Bed Fred by L. Bailey
Authors: Borle Sean 
Published: May 2018

Bailey, Linda. Under the Bed Fred. Tundra Books, 2017.In this offering of the “monsters are not scary” genre, award winning author Linda Bailey has written a chapter book for newly independent readers. There are five chapters telling the story of Leo, who is afraid of the monster, Fred, who lives under his bed. Eventually Leo befriends Fred and discovers he is not scary. He takes Fred to school, where Fred defends him against the class bully, who is portrayed as a red-headed child with a green shirt. Most readers will relate to dealing with a bully at school.The book is well paced for a new reader’s daily reading time. The text is simple and nearly every page has an illustration. One can imagine a child in Grade 2 or 3 being able to read a chapter each day and feel success at having completed a 63 page book by the end of a week.The illustrations are comic style. The monster looks a lot like a brown bear. There are lots of action images, extreme expressions, and speech balloons. The text appears as a very large typeface to emphasize something scary or loud. Sometimes the text is printed at an angle and sometimes words like “KNOCK! KNOCK! KNOCK!”, “GRRRRRROWWLL!” and “CRASH! OOF! POP!” are printed over images for effect.Overall, this is a good book and it is therefore recommended for public and school libraries. Recommendation: 3 stars out of 4Reviewer: Sean C. BorleSean Borle is a University of Alberta undergraduate student who is an advocate for child health and safety.
A New Song for Herman by P. McAllister
Authors: Borle Sean 
Published: May 2018

McAllister, Paul. A New Song for Herman. Herman’s Monster House Publishing, 2017.There are many books designed to help children who are afraid of monsters. This is the second book that Paul McAllister has written on the subject. In this one, Herman, a green House Monster turned Barista Monster, works at Sarah’s cafe and is famous for his mochaccinos. However, his work is suffering because he is being kept awake at night by an Attic Monster. It turns out that the Attic Monster is just baking cookies in an old Easy Bake Oven, so Herman offers him a job baking at the restaurant. The text is simple, but includes some repetition of the Attic Monster’s song “humba rumba lumba rumba gurgle gurgle bing!”, which children will enjoy and will want to repeat during a reading. Both the text and the illustrations help children identify with monsters rather than being afraid of them. Emily Brown has made the monsters look like cuddly stuffy toys. Even the Attic Monster who scares Herman turns out to be “the cutest little monster he’d ever seen.” Brown has also included fun details in the illustrations. For example, when Herman is at his most sleep deprived, he makes the coffee with dirt and Brown shows him holding a coffee pot that has a flower growing out of it. This fun book is recommended for public and school library collections.Recommended: 3 stars out of 4Reviewer: Sean C. BorleSean Borle is a University of Alberta undergraduate student who is an advocate for child health and safety.
ZAP! Nikola Tesla Takes Charge by M. Kulling
Authors: Distad Merrill 
Published: May 2018

Kulling, Monica. ZAP! Nikola Tesla Takes Charge. Illustrated by Bill Slavin. Tundra Books, 2016.In this, her ninth contribution to Tundra Books’ Great Ideas Series, prolific children’s author Monica Kulling distills and simplifies the life and inventions of immigrant engineer and scientist Nikola Tesla (1856–1943) for primary school readers. Confining her story to the first half of Tesla’s long life, from his humble origins in Slovenia (then a part of the Austro-Hungarian Empire), to his achievements as nineteenth-century America’s foremost electrical engineering genius, Kulling has maintained a manageable length compatible with the attention span of her audience.The rivalry between Tesla and his one-time patron and employer, Thomas Edison, over the suitability of alternating versus direct electrical current (AC vs. DC) is described without exposing all the sordid details of their rivalry. The story then quickly moves on to Tesla’s partnership with George Westinghouse to illuminate the 1892-93 Chicago world’s fair site, and to build the first hydroelectric power plant at Niagara Falls, employing alternating current, a system that allowed electricity to be transmitting over greater distances more cheaply and efficiently than Edison’s rival system. Kulling ends her story in 1898, when Tesla demonstrated a model boat controlled by radio waves, an invisible force that he suggested might also be used for wireless communication, a concept soon made real by radio pioneer Guglielmo Marconi.Apart from an anachronistic use of the word “robot,” Kulling’s text is historically and scientifically accurate, clearly written, and age-appropriate, without being condescending. Bill Slavin’s illustrations are nicely evocative of the late nineteenth-century buildings and workshops, and are scaled large enough for story-hour readings to groups of children.Reviewer: Merrill DistadHighly recommended: 4 out of 4 starsMerrill Distad is Associate University Librarian (Research and Special Collections Services) and University Archivist, University of Alberta, and is the co-editor of Peel’s Bibliography of the Canadian Prairies to 1953 (Toronto, 2003). He is the author, most recently, of The University of Alberta Library: The First Hundred Years, 1908–2008 (Edmonton, 2009).
Turtles All the Way Down by J. Green
Authors: Ratcliffe Caitlin 
Published: May 2018

Green, John. Turtles All the Way Down. Dutton Books, 2017. Turtles All the Way Down ticks many boxes; it has friendship, mystery, and romance. Above all, it is the coming-of-age story of a girl struggling with mental illness.Sixteen-year-old Ava Holmes lives within the ever-tightening spiral of her own thoughts. When billionaire Russell Pickett goes missing under suspicious circumstances, Ava and her “Best and Most Fearless Friend,” Daisy, investigate in the hope of pocketing the reward money. Along the way, Ava renews her childhood friendship with Russell’s son, Davis, and their relationship turns romantic as the two teens explore love and their burgeoning sexuality. Yet these elements of typical YA are filtered through the lens of Ava’s mental illness and her daily struggle with profound anxiety, obsessive thinking, and intrusive thoughts. Ava uses the metaphor of an ever-tightening spiral to conceptualize her obsessive thought patterns. The mystery and the romance plotlines are continuously sidelined by Ava’s ongoing struggle with her own mind. Ava’s illness threatens her relationship with Davis, her friendship with Daisy, and, eventually, her life.John Green is a YouTube personality and an award-winning author, best known for The Fault in Our Stars (2012). This novel fits the pattern of Green’s previous works, which feature poignantly relatable teenagers seeking to understand their place in the world. But in Turtles All the Way Down, Green uses the structure of the YA novel to depict the mental illness that has affected his life since childhood. Readers familiar with Green’s virtual presence will hear echoes of his voice in Ava’s. The novel carries the weight of authenticity, as neither Ava nor the reader can find relief from the obsessive thought spirals. By bringing the reader into Ava’s head, Green bridges the gap between language and Ava’s (and his own) abstract experiences. Ava’s chronic mental illness is not magic-ed away, and the novel’s ending is plausible and moving in its truthfulness. A few elements in the novel feel forced. The climax, for instance, seems to happen simply because the structure of the novel requires one. However, Ava’s daily struggle living with her obsessive thoughts is painfully authentic. Though Green writes through the eyes of a teenage girl, his stream-of-consciousness prose may be easily understood by a wide variety of readers. This novel is a stark, honest, and accessible portrayal of living with mental illness. It is a difficult, astonishing read that is highly recommended for those seeking to understand mental illnesses on a personal level.Highly recommended: 4 out of 4 starsReviewer: Caitlin RatcliffeCaitlin Ratcliffe is an MLIS candidate at the University of Alberta. She completed her Bachelor of Arts with a double major in English and History at the University of Lethbridge. When not studying, she enjoys playing soccer and reading sci-fi, fantasy, and young adult fiction.
Análisis de las cadenas de suministro de bio-etanol y biodiesel en México: Estudio de caso
Authors: Rosas Barajas José Alfredo , Aguilar Ortega Andrés , Cornejo Corona Ivete , Rizo Fernández Zenon , Córdova de la Cruz Saúl Edén , Ramos Frausto Luis Gerardo , Esparza Claudio José de Jesús 
Published: May 2018

El trabajo identificó y analizó el estado actual de los principales actores que intervienen en las cadenas de suministro de biocombustibles líquidos en el sureste de México. Se incluye la descripción del proceso de producción de: biodiesel, bioetanol y aceite de ricino. El caso A se refiere a una empresa que a partir de aceites vegetales reciclados produce biodiésel, el caso B se refiere a una empresa que utiliza melazas para producir etanol anhidro mediante un tamiz molecular, el caso C describe la gestión de la cadena de suministro, desde la orga-nización de los agricultores hasta el proceso de producción de aceite de ricino y su comer-cialización para la industria, los centros INIFAP están trabajando en la mejora de la semilla de jatropha para su uso colectivo en las zonas potenciales de cultivo.
Oximes of Nucleosides and Related Compounds: Synthesis, Reactions and Biological Activity
Authors: Abele Edgars , Abele Ramona 
Published: May 2018

Background:
Literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous
bases from pyrimidine and purine were reviewed. Synthesis of novel heterocyclic systems from nucleoside
oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside
and nitrogenous base oximes was also reviewed.
<p>
Objective: The review focuses on the recent progress in the area of nucleoside oxime synthesis, reactions and
biological activity.

Conclusion:
In summary, literature data on the synthesis and structure of oximes of nucleosides and related
nitrogenous bases derived from pyrimidine, which play an important role in the biological processes, were reviewed.
Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described.
The biological activity of derivatives of nucleoside and nucleotide oximes was also reviewed. The
studied class of compounds show a wide range of imino-amino and imino-nitroso tautomerism, which was investigated
in the presented literature by 1H, 13C and 15N NMR spectroscopy methods. Also, according to the
authors point of view, due to imino-amino and/or imino-nitroso tautomerism the nucleoside oximes show interesting
activity. Most of the compounds exhibit biological activity characteristic of not only oxime derivatives,
but also activity of hydroxylamines or nitroso compounds.
Effect of Carrot Pomace Powder and Dushab (Traditional Grape Juice Concentrate) on the Physical and Sensory Properties of Cakes: A Combined Mixtures Design Approach
Authors: Mohtarami Forogh 
Published: May 2018

Background:Carrot pomace powder (CPP), a valuable by-product of carrot processing, and Dushab, a traditional grape juice concentrate, can be utilized for enrichment of products.Methods:Combined mixtures methodology using D-optimal design was found to be an effective technique to investigate the effects of replacing wheat flour and sucrose with CPP and Dushab on water activity, moisture content, specific volume, crumb color and textural properties of cakes and their sensory evaluation.Results:Moisture content, color difference and browning index of cakes increased with an increase in the amount of CPP and Dushab substitution. The specific volume of the cakes reduced in the supplemented CPP and Dushab cakes. By increasing the level of CPP and Dushab, the firmness of the cakes increased whereas cohesiveness decreased. Chewiness and gumminess were not affected by Dushab substitution but increased by the increment of CPP. Dushab substitution led to the decline of cake springiness compared to the control one. The least sensory accepted product, with a mean score of 0.7 in a scale from 0 to 1, had the maximum substitution of CPP (24% wheat flour) and Dushab (100% sucrose).Conclusion:The optimization tool indicated that a functional cake with high desirability can be achieved with the substitution of 10% wheat flour by CPP and 65% sucrose by Dushab.
4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors
Authors: Borkar Maheshkumar R. , Nandan Santosh , Nagaraj Harish K.M. , Puttur Jayashree , Manniyodath Jisha , Chatterji Dipankar , Coutinho Evans C. 
Published: May 2018

Background:
The treatment of a bacterial infection when the bacterium is growing in a
biofilm is a vexed issue. This is because the bacteria in a biofilm behaves differently compared to
the individual planktonic free-form. As a result, traditional antibacterial agents lose their activity.

Objective:
Presently, there are not many drugs that are effective against bacteria growing in
biofilms. Based on literature reports, we have sought to develop novel derivatives of 4-hydroxy-2-
pyridone as both antimycobacterial and antibiofilm agents.
</P><P>
Methods: The pyridone derivatives were synthesized by reacting 4-hydroxy-6-methyl-2H-pyran-2-
one with appropriate amines and followed by reaction with substituted phenyl isocyanates as reported
in the literature.

Results:
Four compounds in this series significantly inhibit the growth and formation of biofilm by
Mycobacterium smegmatis (mc2 155 strain) at 50 µg/ml. Further, in silico evaluation of the ADME
parameters shows that these compounds possess good drug-like properties and have the potential
to be developed both as antibiofilm and as oral antimycobacterial agents.

Conclusion:
This finding is of significance as presently very few small molecules are known to
inhibit biofilm formation in mycobacteria. These compounds are unique in the sense that they are
more potent against Mycobacterium smegmatis in the biofilm state compared to the planktonic
form.
Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments
Authors: Campos-Rodríguez Carolina , Trujillo-Ferrara José G. , Alvarez-Guerra Ameyali , Vargas Irán M. Cumbres , Cuevas-Hernández Roberto I. , Andrade-Jorge Erik , Zamudio Sergio , Juan Eduardo R.-S. 
Published: May 2018

Background:
Thalidomide, the first synthesized phthalimide, has demonstrated sedative-
hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides
have an interesting chemical structure that confers important biological properties.

Objective:
Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral
phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic
and anticonvulsant effects were tested.

Method:
Homology modeling and molecular docking were employed to predict recognition of the
analogues by hNMDA and mGlu receptors. The neuropharmacological activity was tested with the
open field test and elevated plus maze (EPM). The compounds were tested in mouse models of
acute convulsions induced either by pentylenetetrazol (PTZ; 90 mg/kg) or 4-aminopyridine (4-AP;
10 mg/kg).

Results:
The ortho and para non-chiral compounds at 562.3 and 316 mg/kg, respectively, decreased
locomotor activity. Contrarily, the chiral compounds produced excitatory effects. Increased
locomotor activity was found with S-TGLU and R-TGLU at 100, 316 and 562.3 mg/kg,
and S-TASP at 316 and 562.3 mg/kg. These molecules showed no activity in the EPM test or PTZ
model. In the 4-AP model, however, S-TGLU (237.1, 316 and 421.7 mg/kg) as well as S-TASP
and R-TASP (316 mg/kg) lowered the convulsive and death rate.

Conclusion:
The chiral compounds exhibited a non-competitive NMDAR antagonist profile and
the non-chiral molecules possessed selective sedative properties. The NMDAR exhibited stereoselectivity
for S-TGLU while it is not a preference for the aspartic derivatives. The results appear to
be supported by the in silico studies, which evidenced a high affinity of phthalimides for the
hNMDAR and mGluR type 1.
Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis
Authors: Gul Halise Inci , Tugrak Mehtap , Gul Mustafa , Sakagami Hiroshi , Umemura Naoki , Anil Baris 
Published: May 2018

Background:
In this study, new azafluorenones, 4-(4-fluorophenyl)-2-(4-substitutedphenyl)-5Hindeno[
1,2-b] pyridin-5-one, I1-I8 were synthesized and chemical structures were elucidated by spectral analysis.
All compounds were reported for the first time here.

Method:
Compounds were tested in terms of cytotoxicity. They were found as cytotoxins/anticancer
compounds.

Results:
It was found that the lead compounds of the series were I5 and I8 according to SI, TS, PSE calculations.
When PSE values were considered, compound I5 having chlorine had the highest PSE value of 126.4.
Second highest PSE value of 50.5 belonged to I8, which had thiophene ring in its chemical structure. I8 as a
representative compound of the series was forwarded to cell cycle analysis. I8 arrested S phase of the cell cycle
and lead to apoptosis by inducing PARP cleavage suggesting that at least one of the mechanisms of cytotoxic
action of the series was apoptosis.

Conclusion:
It was clearly demonstrated that compound I8 can induce early apoptosis at a concentration of 5
µM. The compounds I5 and I8 can be considered as lead compounds of the series with the highest SI, TS, PSE
values for further studies.
Impacts of Authority and Unanimity on Social Conformity in Online Chats about Climate Change
Authors: Farmer Yanick , Bissière Mehlia , Benkirane Amina 
Published: May 2018

Background The purpose of this study was to examine whether two variables of persuasive communication, authority and unanimity, induce social conformity when people communicate over digital social media without knowing each other. Analysis Data collection was based on a mixed methodology. In all, 26 subjects were tested ( N = 26). Conclusions and implications The research showed that the tendency of conforming to groups is maintained in online communications. However, the level of such conformity is not as high as the level that prevails in face-to-face communication.