bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porcine parvovirus infection induces necroptosis of porcine placental trophoblast cells via a ZBP1-mediated pathway
Authors: Xu Ning , Du Qian , Cheng Yijiao , Nie Lichen , Ma Peipei , Feng Dingwen , Huang Yong , Tong Dewen 
Published: November 2024

AbstractPorcine parvovirus (PPV) infection induces germ cell death, leading to reproductive disorders in first-pregnant sows. Porcine placental trophoblast cells (PTCs) are the major target of PPV, and we have previously found that PPV infection leads to the death of PTCs by a non-apoptotic process, which may be related to PPV pathogenicity. The Z-nucleic acid-binding protein 1 (ZBP1) is often activated after virus invasion and mediates subsequent cell death. Here, we found that PPV infection induced ZBP1-mediated necroptosis of porcine PTCs in the presence of the apoptosis inhibitor, AC-DEVD-CHO. ZBP1 expression was upregulated during PPV infection, and ZBP1 knockout or RNA interference significantly reduced its expression along with the PPV-induced necroptosis. We discovered that RIPK3 and MLKL, but not Caspase-8, were involved in downstream signaling of ZBP1 during PPV infection; the phosphorylation levels of RIPK3 and MLKL were enhanced, but Caspase-8 was not significantly cleaved. The knockout of RIPK3 and MLKL significantly reduced the PPV infection-induced necroptosis of porcine PTCs. RIPK3 knockout did not affect the PPV infection-induced upregulation of ZBP1 expression, but blocked the activation of MLKL. MLKL knockout did not affect the upregulation of ZBP1 expression and RIPK3 phosphorylation during PPV infection. UV-inactivated PPV induced significantly less necroptosis of porcine PTCs than non-irradiated PPV. A PPV strain with a mutation in the translation initiation codon was still able to induce necroptosis of PTCs through the ZBP1/RIPK3/MLKL pathway. These results provide new insights into the pathogenic mechanism of PPV infection and suggest that PPV infection of porcine PTCs induces necroptosis through the viral DNA-dependent ZBP1/RIPK3/MLKL pathway.
The benefit of early acupuncture within 7 days for neurological outcomes in ischemic stroke patients after cardiac surgery
Authors: Kuan Chia-Hsuan , Tseng Chi-Nan , Huang Tse-Hung , Yang Chien-Chung , Chen Yu-Sheng 
Published: November 2024

Abstract
Background
Stroke is a critical complication of cardiac surgery that results in increased mortality and morbidity. Limited treatment options are available for patients with severe neurological deficits, such as impaired consciousness. Acupuncture is a well-known integrative management method for stroke patients. However, there are no extensive reports discussing the benefit of acupuncture in stroke patients after cardiac surgery. The aim of this study was to demonstrate the role of acupuncture in the neurological recovery of these patients and to identify the factors that provide greater benefit.

Methods
This self-controlled case series utilized inpatient data from stroke patients after cardiac surgery who received acupuncture in a single center from 2013 to 2019. The primary outcomes included the Glasgow Coma Scale, muscle strength grading scale, and Barthel Index. Wilcoxon signed-rank test was used to compare the neurological differences between pre-acupuncture and post-acupuncture.

Results
Fifty-one patients who met the criteria showed significant improvement of the severity of neurological impairment, including the Glasgow Coma Scale, muscle strength grading scale, and Barthel Index (p < 0.05). The group that underwent aortic dissection repair and the group that started acupuncture within 7 days after stroke showed greater improvement (p < 0.01). No adverse events were reported. Three patients with profound neurological impairment who received acupuncture intervention were described.

Conclusions
Acupuncture has a potential benefit in improving neurological impairment and reducing mortality in stroke patients after cardiac surgery, especially within 7 days of the event. Further larger prospective studies with control groups are needed to provide convincing evidence.
Large language model doctor: assessing the ability of ChatGPT-4 to deliver interventional radiology procedural information to patients during the consent process
Authors: Hofmann Hayden L. , Vairavamurthy Jenanan 
Published: November 2024

Abstract
Purpose
The study aims to evaluate how current interventional radiologists view ChatGPT in the context of informed consent for interventional radiology (IR) procedures.

Methods
ChatGPT-4 was instructed to outline the risks, benefits, and alternatives for IR procedures. The outputs were reviewed by IR physicians to assess if outputs were 1) accurate, 2) comprehensive, 3) easy to understand, 4) written in a conversational tone, and 5) if they were comfortable providing the output to the patient. For each criterion, outputs were measured on a 5-point scale. Mean scores and percentage of physicians rating output as sufficient (4 or 5 on 5-point scale) were measured. A linear regression correlated mean rating with number of years in practice. Intraclass correlation coefficient (ICC) measured agreement among physicians.

Results
The mean rating of the ChatGPT responses was 4.29, 3.85, 4.15, 4.24, 3.82 for accuracy, comprehensiveness, readability, conversational tone, and physician comfort level, respectively. Percentage of physicians rating outputs as sufficient was 84%, 71%, 85%, 85%, and 67% for accuracy, comprehensiveness, readability, conversational tone, and physician comfort level, respectively. There was an inverse relationship between years in training and output score (coeff = -0.03413, p = 0.0128); ICC measured 0.39 (p = 0.003).

Conclusions
GPT-4 produced outputs that were accurate, understandable, and in a conversational tone. However, GPT-4 had a decreased capacity to produce a comprehensive output leading some physicians to be uncomfortable providing the output to patients. Practicing IRs should be aware of these limitations when counseling patients as ChatGPT-4 continues to develop into a clinically usable AI tool.
A novel wall interference correction method for airfoil
Authors: Wei Binbin , Gao Yongwei , Qiao Ruiyang , Hu Shuling 
Published: November 2024

AbstractCorrections for wind tunnel experimental results are crucial when accounting for tunnel wall interference. This study introduces a new method, the non-uniform wall pressure signature method (NUWPSM), which is designed to address tunnel wall interference in airfoil. The improved wall pressure signature method (WPSM), an enhanced version of the WPSM, is developed to address the velocity disparities and systematic errors in pressure measurements between with and without model conditions. Furthermore, the NUWPSM considers the non-uniformity of the flow induced by the limited far-field effect in wind tunnel experiments. Utilizing experimental data from three different scaled models of the WA210 airfoil, the efficacy of both the Improved WPSM and NUWPSM is verified. Results indicate that the Improved WPSM exhibits superior capabilities in simulating the distribution of axial induced velocity along the wall compared to the traditional WPSM. Additionally, both the Improved WPSM and NUWPSM demonstrate comparable abilities in correcting tunnel wall interference, achieving precise corrections within an angle of attack range of −180° to +180°. Notably, the NUWPSM effectively captures the velocity non-uniformity induced by the limited far-field effect, thereby extending its applicability to a broader range of scenarios. Furthermore, the NUWPSM showcases enhanced robustness by eliminating human intervention in the singularity quantity and distribution.
The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation
Authors: Pinheiro Amanda , Petty Christopher A. , Stephens Chelsea E. , Cabrera Kevin , Palanques-Tost Eric , Gower Adam C. , Marano Madison , Leviss Ethan M. , Boberg Matthew J. , Mahendran Jawahar , Bock Payton M. , Fetterman Jessica L. , Naya Francisco J. 
Published: November 2024

ABSTRACT
The coordinate regulation of metabolism and epigenetics to establish cell state-specific gene expression patterns during lineage progression is a central aspect of cell differentiation, but the factors that regulate this elaborate interplay are not well-defined. The imprinted Dlk1-Dio3 noncoding RNA (ncRNA) cluster has been associated with metabolism in various progenitor cells, suggesting it functions as a regulator of metabolism and cell state. Here, we directly demonstrate that the Dlk1-Dio3 ncRNA cluster coordinates mitochondrial respiration and chromatin structure to maintain proper cell state. Stable mouse muscle cell lines were generated harboring two distinct deletions in the proximal promoter region, resulting in either greatly upregulated or downregulated expression of the entire Dlk1-Dio3 ncRNA cluster. Both mutant lines displayed impaired muscle differentiation along with dysregulated structural gene expression and abnormalities in mitochondrial respiration. Genome-wide chromatin accessibility and histone methylation patterns were also severely affected in these mutants. Our results strongly suggest that muscle cells are sensitive to Dlk1-Dio3 ncRNA dosage, and that the cluster coordinately regulates metabolic activity and the epigenome to maintain proper cell state in the myogenic lineage.
Abca4, mutated in Stargardt disease, is required for structural integrity of cone outer segments
Authors: Willoughby John J. , Jensen Abbie M. 
Published: November 2024

ABSTRACT
Stargardt disease (STGD), the leading cause of inherited childhood blindness, is primarily caused by mutations in the ABCA4 gene; yet, the underlying mechanisms of photoreceptor degeneration remain elusive, partly due to limitations in existing animal disease models. To expand our understanding, we mutated the human ABCA4 paralogues abca4a and abca4b in zebrafish, which has a cone-rich retina. Our study unveiled striking dysmorphology and elongation of cone outer segments (COS) in abca4a;abca4b double mutants, alongside reduced phagocytosis by the retinal pigmented epithelium (RPE). We report that zebrafish Abca4 protein forms a distinctive stripe along the length of COS, suggesting a potential structural role. We further show that, in wild-type zebrafish, outer segments of cone cells constitutively present externalized phosphatidylserine, an apoptotic ‘eat-me’ signal, and that this pattern is disrupted in abca4a;abca4b double mutants, potentially contributing to reduced RPE phagocytic activity. More broadly, constitutive presentation of the ‘eat-me’ signal by COS − if conserved in humans – might have important implications for other retinal degenerative diseases, including age-related macular degeneration. Our zebrafish model provides novel insights into cone dysfunction and presents a promising platform for unraveling the mechanisms of STGD pathogenesis and advancing therapeutic interventions.
Cross-education Mechanisms and Clinical Rehabilitation Research: A Literature Review
Authors: Sun Liang , Wang Yi , Luo Lanfang , Yang Yi , Luo Jiong 
Published: November 2024

In recent years, cross-education has garnered significant attention in the fields of clinical rehabilitation and sports training. Since the discovery of CE, a growing number of studies have focused on understanding its characteristics for deeper insight and application. Two theoretical models currently attempt to explain this adaptive mechanism and are mutually compatible: the "cross-activation" model, which suggests that adaptations to unilateral exercise extend to the contralateral side of the body, and the "bilateral-access" model, which posits that the motor patterns of unilateral activities are replicated on the opposite side.When formulating clinical rehabilitation prescriptions, factors such as the patient’s gender and training experience must be considered. Males and inexperienced patients seem to benefit more significantly. High-intensity eccentric unilateral resistance training is recommended for rehabilitation exercises, ideally over a period exceeding four weeks with intervals of 1-2 days between sessions. Each intervention should include 2-3 minutes of rest between sets to allow sufficient recovery time, thereby preventing neuromuscular fatigue and enhancing the benefits of CE, ultimately promoting and accelerating the rehabilitation process.
La recuperació dels búnquers de l'Organización Defensiva de los Pirineos, com a espais de mermòria. Exemples de gestió i patrimonialització de les defenses militars franquistes a l'Empordà
Authors: Serrano Jiménez Miquel 
Published: November 2024

Els darrers vint anys s’ha produït una recuperació i dignificació patrimonial en relació als búnquers construïts durant el primer franquisme, entre 1940 i 1955, com a defensa militar per repel·lir possibles atacs procedents de França. Diferents experiències de patrimonialització a tot el Pirineu, la més propera de les quals a la Cerdanya, han obert el camí del reconeixement, la promoció i difusió el patrimoni històric i militar també al’Empordà, on existeix la més gran concentració d’aquest tipus de construccions defensives militars, que són encara relativament desconegudes idesprotegides.
Violencia obstétrica y activismo maternal anishinaabe en Future Home of the Living God: el futurismo indígena de Louise Erdrich
Authors: Segarra-Montero Rosa 
Published: November 2024

Este artículo analiza Un futuro hogar para el dios viviente (2019) [Future Home of the Living God, 2017], obra futurista indígena de la autora chippewa Louise Erdrich, desde una perspectiva de género y de las humanidades médicas. En esta distopía ecocrítica, son dos las instituciones médicas que, desde una mirada occidental, patologizan el cuerpo femenino y lo someten a violencia obstétrica, esto es, prácticas en torno a la maternidad (el embarazo, el parto y el puerperio) sumamente violentas e intrusivas. En este artículo analizaré el modelo médico occidental presente en Un futuro hogar para el dios viviente para demostrar cómo la espacialización colonial y el futurismo reproductivo participan activamente en la violencia obstétrica, una clara forma de biocolonialismo. Con este artículo pretendo poner de relieve cómo las estructuras y prácticas médicas desplegadas por el colonialismo de ocupación, a diferencia de los espacios tradicionales femeninos nativo americanos y el activismo maternal anishinaabe, conforman espacios subyugadores y opresores que desacralizan e instrumentalizan la anatomía femenina y la maternidad.
Modality of input and factors affecting incidental vocabulary learning: reading, listening, and viewing with captions
Authors: Teng Mark Feng 
Published: November 2024

Abstract
The present study examined incidental vocabulary learning (IVL) while considering word-related factors (i.e., word occurrence frequency and word relevance) and learner-related factors (i.e., English proficiency and prior vocabulary knowledge) in different input modes: reading, listening, and viewing captioned videos. Participants were 123 second-year university students learning English as a foreign language (EFL) in China. The participants were randomly assigned to four groups, i.e., three experimental groups of reading, listening, viewing with captions, and a control group. A YouTube video was used as the materials for the three experimental groups. The participants encountered 48 target words in the materials. The control group took the tests without attending the intervention. Learning outcome was based on two tests that measure word meaning recall and recognition while word occurrence frequency, word relevance, vocabulary knowledge, and proficiency were considered. The results indicate that the caption viewing condition was most effective, followed by the reading and listening conditions, in the incidental learning of meaning recall and recognition. The findings also suggest that frequency, word relevance, proficiency, and vocabulary knowledge significantly influenced the IVL outcomes for the immediate posttest. However, their impact was less straightforward for the delayed posttest. Relevant implications based on these findings were discussed.
The Emergence of Arabic Scientific Terminology at the Eastern Contact Zone: Calque and Loanword in Early ʿAbbāsid Time (750–800 CE)
Authors: Abedi Milad , Thomann Johannes 
Published: November 2024

Abstract
Superstratum languages often become substratum languages after military defeats. This was the case with Middle Persian in the Islamic Empire. There were different phases of interference between Middle Persian and Arabic. For example, Middle Persian terms, especially in administration and technology, were borrowed into Arabic. Later, in the first decades of Abbasid rule, a new scientific terminology was developed in Arabic based on translations of Sanskrit and Middle Persian texts in the fields of mathematics, astronomy, and medicine. Besides that, some scientific concepts of Chinese origin were received too. Most of these early Arabic scientific texts are lost, having been replaced later in the 3rd/9th century by translations of Greek scientific works. However, many fragments of them are preserved in secondary tradition, and such materials have been only partially studied. This paper will discuss cases of Arabic borrowings, including calques and loanwords from Sanskrit and Middle Persian.
Wie Hobbes mit dem Naturzustand ein Argument macht. Oder: Wie Hobbes ein Argument für den Naturzustand macht?
Authors: Höhne Ieva 
Published: November 2024

Abstract
This paper deals with Thomas Hobbes’ conception of the state of nature. Deviating from its interpretation as a logically indispensable hypothesis for the purpose of the individualist-contractualist legitimation of the state, the article directs the discussion away from the question of the state of nature’s status within Hobbes’ anthropological or legal framework and towards the issue of where and what kind of evidence for this narrative is supposed to be found. If one interrogates this narrative in epistemological terms, an interpretative perspective is opened up in which ordinary forms of competitive and exploitative behaviour as well as of unmediated rule are of central importance, and the consideration of the state of nature as both a situational-relational and gradual concept is made possible as well as necessary. This contribution not only shows how such interpretative possibility is substantiated by the primary sources, but also asks how it relates to Hobbes’ own reflections on knowledge and scientific method. It is shown that what is crucial here is not the distinction between empirical and idealist approach, but the one between two kinds of experience, the second of which corresponds to a nominalist view of knowledge about politics.
Günther Anders’ philosophischer Okkasionalismus: Methoden, Voraussetzungen, Ziele
Authors: Dries Christian 
Published: November 2024

Abstract
The philosopher, writer and technology critic Günther Anders, né Stern (1902–1992), occasionally referred to his own thinking as “occasional philosophy”. In order to reconstruct this mode of thought, which is also an essential key to understanding Anders, I will refer to a previously unpublished typescript of the same name from his literary estate. This reconstruction will be based on three theses: From the outset, Anders’ work is characterised by a preoccupation with questions of method. Secondly, the tools of occasional philosophy can be found not only in his philosophical writings, but above all in his reflections on art, literature and photomontage. Thirdly, the prima vista eclectic and anti-systematic method is a logical reaction to the fundamentally changed conditions of philosophising in a (post-)modern, technologised society.
Contested Ground: Public Commemorations of the Shoah in Lviv
Authors: Shapiro-Obermair Ekaterina 
Published: November 2024

Abstract
The narratives of World War II, and especially accusations of nationalism and anti-Semitism, are widely used in Russian propaganda to legitimize the military aggression against Ukraine. This article takes a closer look at Lviv, a city with a traditionally strong national identity. While historical events related to the implementation of the Shoah in the city are well researched, less attention has been paid to public perception of them. Besides giving an overview of the local memory actors, the main focus of this article lies on public commemorations, which are considered to be media of the transmission and articulation of historical knowledge. The article first examines the content of speeches, and the manner in which ceremonies are staged. It then questions the views society holds toward the Jewish past and how the Jewish identity is conveyed through these rituals. The study is based on in-situ empirical research conducted between August 2015 and January 2023.
Biology and life table of Oligonychus punicae Hirst (Trombidiformes: Tetranychidae) on three host plants
Authors: González-Hernández Eduardo , Chacón-Hernández Julio César , Heinz-Castro Rapucel T.Q. , Hernández-Juárez Agustín , Moreno-Ramírez Yolanda del Rocío , Neri-Ramírez Efraín 
Published: November 2024

Abstract
Avocado brown mite, Oligonychus punicae (Hirst) (Acari: Tetranychidae), causes significant damage to crops, such as avocado (Persea americana Mill. [Lauraceae]). To implement strategies for integrated management of O. punicae, it is necessary to understand its biology when it feeds on different hosts. Life tables of O. punicae on three host plants (P. americana cv. Hass, Pithecellobium dulce (Roxb.) Benth [Fabaceae] and Rosa hybrida L. [Rosaceae]) were developed under laboratory conditions. The developmental time of immature females differed among the host plants tested and ranged from 10.09 days on P. americana cv. Hass to 12.78 days on R. hybrida. For immature males, it ranged from 10.08 days on P. americana cv. Hass to 12.80 days on R. hybrida. The highest total fecundity was recorded for P. americana cv. Hass (47.48 eggs/female) and was lowest for R. hybrida (21.12 eggs/female). The highest intrinsic rate of increase (r

m
) of O. punicae was registered on P. americana cv. Hass (0.240 day−1) and was lowest on R. hybrida (0.156 day−1). The demographic parameters suggest that R. hybrida is a poor host for the development of O. punicae, and the best O. punicae performance was on P. americana cv. Hass.
Une lamentation pour une cérémonie funèbre avec des références à Dumuzi (MAH 15995)
Authors: Jaques Margaret 
Published: November 2024

Abstract
MAH 15995 is an Old Babylonian lamentation, perhaps for a dead person, with excerpts of prayers to Dumuzi and/or Damu. The content of this lamentation contains unusual aspects that are discussed in the commentary. The format and ductus of the tablet is found in other tablets of the British Museum (BM 15793, BM 15821, BM 22741, BM 23104, BM 23584, BM 23696, and BM 29628).
Les abréviations des compositions correspondent à celles d’Attinger (2021). Je remercie Walther Sallaberger et mon correcteur anonyme pour leurs remarques, ainsi qu’Emmert Clevestine pour ses scans.
A Standardised Demon Sequence
Authors: Barkowsky Marie 
Published: November 2024

Abstract
The article discusses a standardised sequence of demons known from multiple incantations and ritual series. While the order of demons included is remarkably stable from attestation to attestation, the number of demons included can vary, leading to some confusion as to how long the standardised sequence was. The article therefore proposes a maximum length of the series and attempts to trace its development from the Old Babylonian period onwards.