bluuebunny/crossref_metadata_2025_split huggingface dataset:
New cardiovascular biomarkers in patients with advanced cancer – A prospective study comparing MR‐proADM, MR‐proANP, copeptin, high‐sensitivity troponin T and NT‐proBNP
Authors: Anker Markus S. , Lück Laura C. , Khan Muhammad Shahzeb , Porthun Jan , Hadzibegovic Sara , Lena Alessia , Wilkenshoff Ursula , Weinländer Pia , Evertz Ruben , Totzeck Matthias , Mahabadi Amir A. , Rassaf Tienush , Anker Stefan D. , Bullinger Lars , Keller Ulrich , Karakas Mahir , Landmesser Ulf , Butler Javed , von Haehling Stephan 
Published: November 2024

AbstractAimsTraditional cardiovascular (CV) biomarkers (high‐sensitivity troponinT [hsTnT] and N‐terminal pro‐B‐type natriuretic peptide [NT‐proBNP]) are important to monitor cancer patients' cardiac function and to assess prognosis. Newer CV biomarkers (mid‐regional pro‐adrenomedullin [MR‐proADM], C‐terminal pro‐arginine vasopressin [copeptin], and mid‐regional pro‐atrial natriuretic peptide [MR‐proANP]) might outperform traditional biomarkers.Methods and resultsOverall, 442 hospitalized cancer patients without significant CV disease or current infection were enrolled (61 ± 15 years, 52% male, advanced cancer stage: 85%) and concentrations of CV biomarkers were analysed. Differences in echocardiographic, clinical, laboratory parameters were assessed. Patients were followed for up to 69 months for all‐cause mortality. In univariable analyses, MR‐proADM, hsTnT, copeptin, MR‐proANP, and NT‐proBNP predicted all‐cause mortality. In multivariable analyses (adjusted for sex, age, Eastern Cooperative Oncology Group performance status, estimated glomerular filtration rate [eGFR], C‐reactive protein, anti‐cancer therapy, reason for hospitalization, cancer stage and type), only MR‐proADM remained an independent predictor of mortality (MR‐proADM per 1 ln: hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.47–3.50], p < 0.001). MR‐proADM had the highest area under the curve (AUC) using receiver operating characteristic analysis (AUC [95% CI] 0.74 [0.69–0.79]; hsTnT: AUC 0.69; copeptin: AUC 0.66; MR‐proANP: AUC 0.63; NT‐proBNP: AUC 0.62). Optimal cut‐point for mortality prediction with MR‐proADM was 0.94 nmol/L (HR 2.43 [95% CI 1.92–3.06], p < 0.001). Patients with MR‐proADM >0.94 nmol/L were older, more often had cancer stage IV, showed reduced performance status, eGFR, haemoglobin, diastolic left ventricular function, and elevated systolic pulmonary artery pressure.ConclusionMR‐proADM is an independent predictor of mortality in advanced stage, hospitalized cancer patients without significant CV disease or current infection. The optimal MR‐proADM cut‐point for mortality prediction was 0.94 nmol/L with hazards for mortality being approximately 2.5 times higher. There was a continuous increase in mortality risk with stepwise increase of MR‐proADM concentrations. Elevated concentrations of MR‐proADM were also associated with reduced performance status and mildly reduced left ventricular diastolic function as well as higher age and more often cancer stage IV.
Discontinuation and reinitiation of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction
Authors: Landucci Laura , Faxén Ulrika Ljung , Benson Lina , Dahlström Ulf , Carrero Juan J. , Savarese Gianluigi , Lund Lars H. 
Published: November 2024

AbstractAimsMineralocorticoid receptor antagonists (MRA) improve outcomes in heart failure with reduced ejection fraction (HFrEF) but are underused. Point prevalent use has been described, but the kinetics of discontinuation and the extent of reinitiation have not been studied.Methods and resultsPatients with HFrEF enrolled in the Swedish Heart Failure Registry between 2006 and 2021 were linked to the Prescribed Drug Register. The rate of discontinuation during the first year of treatment and reinitiation the year after discontinuation were estimated using the Kaplan–Meier method. Multivariable Cox proportional hazards models were used to assess the predictors of discontinuation. Of 11 474 MRA new users, 71% remained on therapy at 1 year. Baseline characteristics independently associated with discontinuation were: estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m2 (hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.34–2.27), hyperkalaemia (HR 1.73, 95% CI 1.25–2.40), eGFR 30–60 ml/min/1.73 m2 (HR 1.51, 95% CI 1.37–1.66), age ≥80 years (HR 1.26, 95% CI 1.10–1.43), enrolment as inpatient (HR 1.25, 95% CI 1.14–1.38), a diagnosis of atrial fibrillation (HR 1.24, 95% CI 1.10–1.39), living alone (HR 1.23, 95% CI 1.13–1.34), ischaemic heart disease (HR 1.20, 95% CI 1.09–1.31), anaemia (HR 1.17, 95% CI 1.07–1.29), diabetes mellitus (HR 1.15, 95% CI 1.04–1.27) and New York Heart Association class III–IV (HR 1.13, 95% CI 1.02–1.24). Reinitiation within a year occurred in 46% of cases, mostly within 3 months after discontinuation.ConclusionAmong patients with HFrEF initiated on MRA, 71% remained on therapy at 1 year. Discontinuation occurred early and was more common in patients with advanced kidney disease, hyperkalaemia, lack of follow‐up in specialty care, more severe heart failure, comorbidities, and markers of sociodemographic frailty. Among those who discontinued, almost half reinitiated treatment the year following discontinuation.
Asymmetrically Fused Nanographene‐Porphyrin Architectures
Authors: Oleszak Christoph , Ritterhoff Christian L. , Meyer Bernd , Jux Norbert 
Published: November 2024

AbstractA strategy to combine three standalone aromatic building blocks in one coherent, fully conjugated molecule is presented. Namely, benzene, pyrene, and hexa‐peri‐hexabenzocoronene (HBC) are assembled around a central porphyrin core in an ABAC type of geometry and interconnected under oxidative Scholl conditions to achieve merging of the individual π‐systems. The three asymmetric porphyrin conjugates obtained this way exhibit intriguing absorption features, namely strongly red‐shifted and broadened spectra. The presented series of molecules demonstrates the ability to control and influence these optical properties with high precision by altering the size of the aromatic system in a controlled manner. Density functional theory calculations gave more profound insights into the electronic structure and optical transitions of the investigated fused architectures.
Beck Depression Inventory‐II Response Following Parathyroidectomy for Primary Hyperparathyroidism: A Systematic Review and Meta‐Analyses
Authors: Chitnis Om S. , Wagner Sabrina K. , Caraway J. Joseph , Watson Nora L. , Allard Rhonda J. , Orestes Michael I. 
Published: November 2024

ABSTRACTBackgroundThere is currently a lack of consensus regarding neuropsychiatric symptoms as an indication for parathyroidectomy in primary hyperparathyroidism (pHPT). The purpose of this study is to perform a systematic review and meta‐analyses of pre‐ and postoperative Beck Depression Inventory‐II (BDI‐II) scores in patients with pHPT undergoing parathyroidectomy.MethodsA search of the literature was performed using Embase, PubMed, Web of Science, PsycINFO, and OvidAll EBM Reviews. Studies were included if they evaluated BDI‐II scores in pHPT patients before and after parathyroidectomy.ResultsThe literature search returned 1554 studies, of which nine articles met criteria for inclusion. Baseline BDI‐II scores were significantly higher in pHPT patients compared to control patients. pHPT patients experienced a statistically significant decrease in BDI‐II scores at ≤ 1 and 6 months postoperatively.ConclusionsBased on the results of this study, a BDI‐II score ≥ 14 could potentially advocate for parathyroidectomy in patients with pHPT.
Effects of technological issues on session evaluation in metaverse counseling: The role of psychological symptoms using HLM analysis
Authors: Kang Jieun , Tsai Chin‐Chung , Lee Sang Min 
Published: November 2024

AbstractThe main objective of this study was to examine the role of psychological symptoms in the relationship between technological issues and session evaluation within the context of metaverse counseling. Evaluating the effectiveness of sessions within virtual counseling environments and understanding how psychological factors influence clients’ sensitivity to technological issues during these sessions seemed important. Dataset comprising 148 sessions with 25 South Korean clients and 6 counselors was used for analysis. The findings indicated that technological issues negatively influenced each session's evaluation (between session levels), but these issues did not significantly affect the overall session evaluation among clients (between‐client levels). Interestingly, clients with more severe psychological symptoms tended to be less satisfied with each counseling session when faced with more technological difficulties than clients who faced fewer psychological symptoms. The theoretical and practical implications of this study were further discussed, along with suggestions for future research.
Exploring adolescents' and stakeholders' perceptions of online and school‐based mental health provision
Authors: Bell Beth T. , Fox Laura , Salhi Louisa , Fitton Daniel 
Published: November 2024

AbstractBackgroundAdolescents' engagement with online mental health support (e.g., apps, social media) may affect their engagement with traditional support, including in schools. However, research has typically considered engagement with online‐ and school‐based mental health support separately meaning the mesosystemic interaction between the two is overlooked. Using co‐produced exploratory qualitative methods, the present study explored adolescents' and adult stakeholders' perceptions of how and why adolescents engage with school‐based and online mental health support, the interaction between these two modalities, and the associated risks and opportunities.MethodsA youth advisory board (n = 4; Age = 18–25) co‐created data collection methods, ethics procedures, and data analysis. For the main phase of data collection, 27 adolescents (Age M = 15.42, SD = 1.58, Range = 12–18, Girls = 73.1%, White = 84.6%) with mental health difficulties who had engaged with online support while at school were recruited from across England. Participants chose to participate in an interview (n = 10) or focus group (n = 17, 5 groups). In addition, interviews were conducted with 12 adult stakeholders who worked in fields related youth mental health.ResultsData was analysed using template analysis resulting in four themes; (a) Support is abundant, but accessing what you need when you need it is tough, (b) Human connection is vital and can be achieved in diverse ways, (c) Striving for autonomy and control, (d) Navigating credibility and trust across contexts.ConclusionsDifferent types of support met adolescents' needs in different ways, and each offered relative strengths and weaknesses. Findings highlight how adolescents value autonomy and choice when engaging with support, using multiple different sources of support in complementary and self‐directed ways to meet their needs. Several challenges were identified across settings, which could be overcome through increased collaboration. This improved collaboration has potential to improve the quality of support available to adolescents.
Tenascin C deletion impairs tendon healing and functional recovery after rotator cuff repair
Authors: Tashjian Robert Z. , Zitnay Jared , Kazmers Nikolas H. , Veerabhadraiah Shivakumar R. , Zelada Antonio C. , Honeggar Matthew , Smith Matthew C. , Chalmers Peter N. , Henninger Heath B. , Jurynec Michael J. 
Published: November 2024

AbstractThe biological factors that affect healing after rotator cuff repair (RCR) are not well understood. Genetic variants in the extracellular matrix protein Tenascin C (TNC) are associated with impaired tendon healing and it is expressed in rotator cuff tendon tissue after injury, suggesting it may have a role in the repair process. The purpose of the current study was to determine the role of TNC on tendon healing after RCR in a murine model. The supraspinatus tendon was transected and repaired on the left shoulder of wild‐type (WT‐RCR), Tenascin C null (Tnc−‐RCR) and Tnc heterozygous (Tnc+/−‐RCR) mice. Controls included the unoperated, contralateral shoulder of WT‐RCR, Tnc—RCR, Tnc+/−‐RCR mice and unoperated shoulders from age and genotype matched controls. We performed histologic, activity testing, bulk RNA‐seq, and biomechanical analyses. At 8‐weeks post‐RCR, Tnc− and Tnc+/− mice had severe bone and tendon defects following RCR. Tnc−‐RCR mice had reduced activity after RCR including reduced wheel rotations, wheel duration, and wheel episode average velocity compared with WT‐RCR. Loss of Tnc following RCR altered gene expression in the shoulder, including upregulation of sex hormone and WNT pathways and a downregulation of inflammation and cell cycle pathways. Tnc− mice had similar biomechanical properties after repair as WT. Further research is required to evaluate tissue specific alterations of Tnc, the interactions of Tnc and sex hormone and inflammation pathways as well as possible adjuvants to improve enthesis healing in the setting of reduced TNC function.
Serum S100A8/A9 Correlates to Surgery‐Free Interval in Idiopathic Subglottic Stenosis
Authors: Mafla Laura M. , So Raymond J. , Abd‐Elazem Ibrahim , Collins Samuel L. , Chan‐Li Yee , Lilly Gabriela , Lina Ioan A. , Gelbard Alexander H. , Hillel Alexander T. , Motz Kevin M. 
Published: November 2024

ObjectiveIdiopathic subglottic stenosis (iSGS) is a progressive fibrotic condition of the subglottis that presents in women of northern European descent. Endoscopic dilation is a common surgical approach to management of iSGS. The surgery‐free interval, or the time between endoscopic dilation procedures is considered an indicator of disease severity. Variations in surgery‐free intervals among iSGS patients underscore the necessity for prognostic biomarkers. The objective of this study was to explore serum levels of the damage‐associated molecular pattern S100A8/A9 as a prognostic biomarker in iSGS.MethodsSerum from 20 iSGS patients and eight healthy controls was collected and S100A8/A9 levels were quantified using an ELISA. Patient data, including demographics and surgery‐free intervals, were obtained from medical records. Serum S100A8/A9 levels were compared to surgery‐free intervals. S100A8/A9 was also assessed using gene expression and immunofluorescence in iSGS specimens.ResultsS100A8/A9 was significantly elevated (p = 0.0413) in the serum of iSGS patients compared to controls (312.75 vs. 181.49 ng/mL). Linear regression analysis revealed a correlation (p = 0.009) between S100A8/A9 levels and endoscopic surgery‐free interval. S100A8/A9 was significantly elevated (p = 0.0011) in patients with surgery‐free intervals less than 1 year (455.2 ± 60.45 ng/mL; n = 8) compared to patients with intervals over 1 year (292.5.93 ± 162.4; n = 6).ConclusionS100A8/A9 is increased in the serum and tissue of patients with iSGS. In this cohort of iSGS patients, serum S100A8/A9 was associated with surgery‐free intervals, potentially representing a prognostic biomarker. Further research within a larger cohort is needed to confirm these findings.Level of EvidenceLevel 3 Laryngoscope, 2024
Silicon‐Nitride‐Integrated Hybrid Optical Fibers: A New Platform for Functional Photonics
Authors: Yan Zhengyu , Xie Shangran , Wang Caoyuan , Xiong Cong , Yu Ruowei , Linghu Shuangyi , Gu Fuxing , Xu Hongtao , An Zhenhua , Wu Ming , Liu Ai‐Qun , Hua Ping , Peacock Anna C. , Xiao Limin 
Published: November 2024

AbstractHybrid optical fibers that integrate exotic materials within more traditional silica glass architectures open a route for the development of highly functional all‐fiber photonic systems. Here, a compact hybrid optical fiber platform is reported formed by depositing a silicon nitride (SiNx ‐ nitride‐rich) nanolayer onto the surface of fused‐silica microfibers via plasma‐enhanced chemical vapor deposition. The SiNx thickness can be precisely tuned over a range of tens of nanometers, while maintaining an ultra‐smooth deposition surface, allowing for tunable coupling between the modes guided predominantly in the nanolayer and the fiber core. The effective indices of the hybrid modes display an anti‐crossing behavior under resonant conditions, resulting in a rich dispersion landscape that can be tailored via adjusting the SiNx thickness. By fabricating a SiNx‐silica hybrid microfiber with precise dispersion engineering and a low insertion loss, a flat supercontinuum spectrum spanning >1.5 octaves (−20 dB level) has been generated. The results demonstrate that SiNx‐silica hybrid microfibers can offer a unique combination of broadband transmission and wide tunablity of the mode properties, while still retaining the benefits of robust integration with conventional silica glass fiber networks, providing a rich playground for hybrid fiber‐based photonic systems.
Polyharmonic fields and Liouville quantum gravity measures on tori of arbitrary dimension: From discrete to continuous
Authors: Schiavo Lorenzo Dello , Herry Ronan , Kopfer Eva , Sturm Karl‐Theodor 
Published: November 2024

AbstractFor an arbitrary dimension , we study:

the polyharmonic Gaussian field on the discrete torus , that is the random field whose law on given by
where is the Lebesgue measure and is the discrete Laplacian;
the associated discrete Liouville quantum gravity (LQG) measure associated with it, that is, the random measure on
where is a regularity parameter.
As , we prove convergence of the fields to the polyharmonic Gaussian field on the continuous torus , as well as convergence of the random measures to the LQG measure on , for all .
The first eigenvalue of one‐dimensional elliptic operators with killing
Authors: Dai Kang , Sun Xiaobin , Wang Jian , Xie Yingchao 
Published: November 2024

AbstractIn this paper, we investigate the first eigenvalue for one‐dimensional elliptic operators with killing. Two‐sided approximation procedures and basic estimates of the first eigenvalue are given in both the half line and the whole line. The proofs are based on the ‐transform, Chen's dual variational formulas, and the split technique. In particular, a few examples are presented to illustrate the power of our results.
Anisole Processible n‐Type Conjugated Polymers Synthesized via C─H/C─H Oxidative Direct Arylation Polycondensation for Organic Electrochemical Transistors
Authors: Yu Zerui , Jiang Xingyu , Shi Cheng , Shi Yibo , Huang Lizhen , Han Yang , Deng Yunfeng , Geng Yanhou 
Published: November 2024

AbstractThe development of n‐type polymers for organic electrochemical transistors (OECTs) has lagged significantly behind their p‐type counterparts. Moreover, these polymers are often synthesized via Stille polycondensation. Herein, three polymers with thiazole‐flanked diketopyrrolopyrrole is synthesized as the monomer through C─H/C─H oxidative direct arylation polycondensation (Oxi‐DArP). This protocol employs unfunctionalized (C─H terminated) monomers, and the generated byproducts are environmentally benign. The electron‐deficient polymer backbone confers these polymers with LUMO energy levels below −4.20 eV, enabling all of them to exhibit n‐type behavior in OECTs. Additionally, the resulting polymers are soluble in the green solvent anisole. With an optimized alkyl spacer between oligo(ethylene glycol) side chain and conjugated backbone, the polymer gTzDPP‐C8 showed the best device performance with geometry normalized transconductance (gm,norm) up to 6.31 S cm−1 and µC* up to 23.1 F V−1 cm−1 s−1. This work has successfully proved that C─H/C─H Oxi‐DArP is a promising method for synthesizing n‐type OMIECs to fulfill high‐performance OECTs.
A Heat Sensitivity Scale for People with Parkinson's Disease
Authors: Hunt Andrew P. , Pagnussat Aline Souza , Lehn Alexander , Moore Daniel , Schweitzer Daniel , Laakso E‐Liisa , Hennig Ewald , Morris Meg E. , Kerr Graham , Stewart Ian 
Published: November 2024

AbstractBackgroundPeople living with Parkinson's disease (PD) commonly experience heat sensitivity—worsening symptoms and restricted daily activities in heat.ObjectiveThis study aimed to develop a scale of heat sensitivity for people with PD.MethodsThrough a search of the scientific literature and online forums, we developed 41 items relating to experiences of heat for people with PD to assess heat sensitivity. A panel of experts was then consulted to review the scale items critically. After two rounds of review, the scale was refined to 36 items with an overall scale content validity index of 0.89. Via an online survey, 247 people with PD responded to the items.ResultsThe items were examined with exploratory factor analysis to determine the underlying factors therein. After several iterations, a simple structure was achieved with 29 items loading uniquely onto one of four factors: daily activities, sweating and exercise, heat‐related illness, and symptoms and medications. The model had acceptable to excellent fit statistics (root mean square error of approximation = 0.073 [90% confidence interval 0.067–0.081], root mean square of the residuals = 0.03, comparative fit index = 0.93, and Tucker‐Lewis index = 0.91), and each factor showed high reliability (Cronbach's α ≥0.89). Factor and total scale scores were significantly higher among those reporting sensitivity to heat and poor health status.ConclusionThis new heat sensitivity scale for people living with PD can enable health professionals and clients to assess the severity and impact of heat sensitivity.
Use of parenteral nutrition in the management of enterocutaneous fistula
Authors: Kumpf Vanessa J. , Yeh D. Dante 
Published: November 2024

AbstractNutrition plays an integral role in the management of patients with enterocutaneous fistula (ECF), but practice guidelines are often vague because of limited evidence. As a result, clinicians must rely on expert consensus and sound nutrition principles to guide practice. The initial phase of ECF management involves recognition (eg, fistula location and quantifying output) and stabilization (eg, source control and fluid and electrolyte balance). All patients with ECF should be considered at risk of malnutrition because of malabsorption, high gastrointestinal fluid and nutrient losses, and chronic inflammation. Strict bowel rest in conjunction with parenteral nutrition (PN) is typically warranted on initial presentation, but patients can often transition to oral diet or enteral nutrition if ECF output is low (<500 ml/day) and there is good control of ECF drainage at the skin level. Patients with high‐output ECF (>500 ml/day) may require PN to meet fluid, electrolyte, and nutrient requirements to support spontaneous or surgical closure of the ECF. Because the healing process can take months, transfer from the inpatient to home setting should be considered when a patient is medically stable. Preparing for discharge home requires stabilization of fluid and electrolyte balance, achievement of glycemic control, containment of ECF output, and patient and/or caregiver training. A long‐term PN treatment plan should be developed that incorporates outpatient monitoring, determination of target weight, and desired PN end point. The purpose of this article is to review the optimal use of PN in adult patients with ECF.