bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma
Authors: Tobochnik Steven , Regan Michael S. , Dorotan Maria K.C. , Reich Dustine , Lapinskas Emily , Hossain Md Amin , Stopka Sylwia , Meredith David M. , Santagata Sandro , Murphy Melissa M. , Arnaout Omar , Bi Wenya Linda , Chiocca E. Antonio , Golby Alexandra J. , Mooney Michael A. , Smith Timothy R. , Ligon Keith L. , Wen Patrick Y. , Agar Nathalie Y.R. , Lee Jong Woo 
Published: November 2024

Abstract

Purpose:
Glutamatergic neuron–glioma synaptogenesis and peritumoral hyperexcitability promote glioma growth in a positive feedback loop. The objective of this study was to evaluate the feasibility and estimated effect sizes of the targeted AMPA receptor antagonist perampanel on peritumoral hyperexcitability.

Experimental Design:
An open-label trial was performed comparing perampanel with standard of care (SOC) in patients undergoing resection of newly diagnosed radiologic high-grade glioma. Perampanel was administered as a preoperative loading dose followed by maintenance therapy until progressive disease or up to 12 months. SOC treatment involved levetiracetam for 7 days or as clinically indicated. The primary outcome of hyperexcitability was defined by intraoperative electrocorticography high-frequency oscillation (HFO) rates. Seizure freedom and overall survival were estimated by the Kaplan–Meier method. Tissue concentrations of perampanel, levetiracetam, and correlative biomarkers were measured by mass spectrometry.

Results:
HFO rates were similar between patients treated with perampanel and levetiracetam. The trial was terminated early after a planned interim analysis, and outcomes assessed in 11 patients (seven perampanel treated; four treated with SOC). Over a median 281 days of postenrollment follow-up, 27% of patients had seizures, including 14% maintained on perampanel and 50% treated with SOC. Overall survival in perampanel-treated patients was similar to that in a glioblastoma reference cohort. Glutamate concentrations in surface biopsies were positively correlated with HFO rates in adjacent electrode contacts and were not significantly associated with treatment assignment or drug concentrations.

Conclusions:
Glioma peritumoral glutamate concentrations correlated with high-gamma oscillation rates. Targeting glutamatergic activity with perampanel achieved similar electrocorticographic hyperexcitability levels as in levetiracetam-treated patients.
Diagnosing Monogenic Stroke at Younger Age
Authors: Ilinca Andreea , Kafantari Efthymia , Wallenius Joel , Kristoffersson Ulf , Englund Elisabet , Puschmann Andreas , Lindgren Arne G. 
Published: November 2024

BACKGROUND:
An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age.

METHODS:
Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or more first to second degree relatives with stroke under 60 years or same stroke-causing condition/disease; (2) no hypertension, hypercholesterolemia, diabetes, heart disease, or smoking; or (3) either multiple stroke episodes or multiple arterial dissections. Variants with minor allele frequency under 0.01, identified by using our stroke gene panels, were assessed. The stroke subtypes, including large artery atherosclerotic, large artery nonatherosclerotic (tortuosity, dolichoectasia, aneurysm, nonatherosclerotic dissection, or occlusion), cerebral small vessel disease, cardioembolic (arrhythmia, heart defect, or cardiomyopathy), coagulation dysfunctions (venous thrombosis, arterial thrombosis, or bleeding tendency), intracerebral hemorrhage, vascular malformations (cavernoma or arteriovenous malformations), metabolic disorders, or cryptogenic embolic, were used for genotype-phenotype correlation. In a final step, we combined genetic and clinical information to determine if the genetic variant likely was the cause of stroke in the patients.

RESULTS:
Whole genome sequencing of younger patients with stroke identified 17 clinically matching genetic variants in 15 of 50 (30%) patients, while a stronger clinical correlation with stroke was established in only 6 (12%) of them. Stroke-related genetic variants were identified in 4 of 5 (80%) patients with cardioembolic stroke subtype, 3 of 4 (75%) with intracerebral hemorrhage, 7 of 18 (39%) with cryptogenic embolic stroke, 1 of 6 (17%) with small vessel disease, and 3 of 15 (20%) of patients with nonatherosclerotic large artery stroke, including 1 of 11 (9%) with cervical dissection stroke.

CONCLUSIONS:
Careful clinical interpretation of whole genome data using stroke gene panels can detect monogenic causes of early stroke, allowing individualized follow-up and opening new possibilities for potential treatment.
Open Science at the generative AI turn: An exploratory analysis of challenges and opportunities
Authors: Hosseini Mohammad , Horbach Serge P. J. M. , Holmes Kristi , Ross-Hellauer Tony 
Published: November 2024

Abstract
Technology influences Open Science (OS) practices, because conducting science in transparent, accessible, and participatory ways requires tools and platforms for collaboration and sharing results. Due to this relationship, the characteristics of the employed technologies directly impact OS objectives. Generative Artificial Intelligence (GenAI) is increasingly used by researchers for tasks such as text refining, code generation/editing, reviewing literature, and data curation/analysis. Nevertheless, concerns about openness, transparency, and bias suggest that GenAI may benefit from greater engagement with OS. GenAI promises substantial efficiency gains but is currently fraught with limitations that could negatively impact core OS values, such as fairness, transparency, and integrity, and may harm various social actors. In this paper, we explore the possible positive and negative impacts of GenAI on OS. We use the taxonomy within the UNESCO Recommendation on Open Science to systematically explore the intersection of GenAI and OS. We conclude that using GenAI could advance key OS objectives by broadening meaningful access to knowledge, enabling efficient use of infrastructure, improving engagement of societal actors, and enhancing dialogue among knowledge systems. However, due to GenAI’s limitations, it could also compromise the integrity, equity, reproducibility, and reliability of research. Hence, sufficient checks, validation, and critical assessments are essential when incorporating GenAI into research workflows.
Carry Trades and FX Risk Buffers: Foreign Currency Debt of Emerging Market Firms
Authors: Lee Annie Soyean , Yeung Wu Steve Pak 
Published: November 2024

Abstract
The surge in foreign currency (FC) corporate debt in emerging economies has sparked concerns about macroeconomic stability, heightened by speculation about non-financial firms engaging in carry trades. Using firm-level data on the currency denomination of both assets and liabilities, we find evidence of firms' carry trades: firms save in local currency liquid assets and earn higher interest income after issuing short-term FC debt. They also set aside FC liquid assets as FX risk buffers. A large degree of heterogeneity in incentives is observed. Notably, listed firms participate more in carry trades and allocate less FX risk buffers than non-listed firms.
Technology and Humanity in Chinese Christian Perspective
Authors: 賴 品超 , 鍾 俊明 
Published: November 2024

Abstract
The ideas of transhumanism and Anthropocene supported by contemporary technological developments seem to contradict the Christian understanding of humanity. Based on a review of the relationship between the interpretations of the doctrine of imago Dei and the developments of technology in the Western world, this essay reinterprets the concept of imago Dei in connection with the concept of the “garment of skin” by making references to the Orthodox tradition represented by Maximus the Confessor (579–662). After spelling out its implications for the understanding of the relationship between humanity and technology, this essay explains further how the Confucian understanding of humanity and technology is compatible with and can enrich the Christian understanding. The resultant Chinese Christian understanding of humanity, integrating the traditions of Christian theology and Chinese culture, supports an affirmative and yet critical view of technology and challenges transhumanism and Anthropocene by offering a more adequate and balanced view of technology and humanity.
Prevalence and risk factors of hospital acquired venous thromboembolism
Authors: Li Hai-Lei , Zhang He , Chan Yiu Che , Cheng Stephen W 
Published: November 2024

Objectives To investigate the prevalence, clinical characteristics and risk factors of hospital acquired venous thromboembolism (HA-VTE) in a Chinese Hospital. Methods Retrospective analysis of patients diagnosed as HA-VTE in a single institution from January 2016 to December 2022 was performed. Patients with VTE prior to admission or within 48 h after admission were excluded. Demographic data of patients was retrieved from the electronic medical database, and parameters affecting the occurrence of HA-VTE were analyzed. Results 4,022 patients from 321,997 episodes of medical admissions were diagnosed as VTE. Among these, 952 (23.7%) fulfilled the criteria of HA-VTE, corresponding to an incidence of 0.296%. 76% of patients presented with HA-deep vein thrombosis (DVT) alone, 13% presented with isolated HA-pulmonary embolism (PE), and 11% presented with concomitant HA- DVT and PE. Risk factor analyses showed statistically higher incidence in patients with elder age (67.5 ± 15.5 vs 48.3 ± 17.2 years, p < .001), male gender (0.346% vs 0.262%, p < .001), malignancy (0.513% vs 0.252%, p < .001), trauma (0.659% vs 0.28%, p < .001), emergency admission (0.664% vs 0.186%, p < .001), ICU stay (2.981% vs 0.226%, p < .001), and patients undergoing major surgery (0.702% vs 0.176%, p < .001). Patients with HA-VTE had longer hospital stay (22.5 ± 26.6 vs 7.21 ± 9.23 days, p < .001) and higher mortality rate (8.51% vs 1.01%, p < .001). The crude incidence rate of HA-VTE increased annually from 0.75 per 1,000 patients in 2016 to 5.89 per 1,000 patients in 2022. The subspecialties with the highest incidence rate of HA-VTE were cardiovascular surgery (1.40%), neurosurgery (1.10%), and respiratory medicine (0.72%). Conclusion This is one of the few large scale studies to show that HA-VTE, accounting for nearly one quarter of all VTE events, occurs in 0.296% of adult hospitalizations. Patients with elder age, malignancy, ICU stay, and undergoing major surgery require more intensive HA-VTE surveillance and prevention.
Rituximab in lupus anticoagulant hypoprothrombinemia syndrome: A case report
Authors: Agnelli Giacchello Jacopo , Trincheri Nicol Francesca , Sciancalepore Patrizia , Contino Laura , Santi Roberto Mario , Pengo Vittorio 
Published: November 2024

Background Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune condition characterized by acquired prothrombin (FII) deficiency associated with antiphospholipid syndrome (APS) and life-threatening bleeding. We present the case of a 34-year-old woman with heavy menstrual bleeding (HMB), positive Lupus anticoagulant (LA) test, and high titer anticardiolipin antibodies Immunoglobulin G (ACA IgG) and anti-β2 glycoprotein I antibodies IgG (antiB2GPI IgG). Severe iron deficiency anemia necessitated recurrent blood transfusions and intravenous iron infusions from 2018 to 2021. Results In January 2022, she was admitted to our clinic. Von Willebrand disease screening and platelet function analysis (PFA100) were normal. FII and FIX deficiencies were detected, without factor IX inhibitors. Anti-phosphatidylserine/prothrombin antibodies were confirmed by Padua University lab. To reduce antibody titers and menstrual bleeding, immunosuppressive therapy (Rituximab 375 mg/m2 weekly ×4 weeks) and hormonal therapy (desogestrel 75 mcg/day) were initiated. Conclusion After 1-year, complete remission of clinical symptoms was achieved, with normalization of FII and FIX values and moderate reduction of aPS/PT titers, especially IgM isotype.
Angiotensin-Converting Enzyme Inhibitor Washout Period Prior to Angiotensin Receptor/Neprilysin Inhibitor Initiation in the Inpatient Setting
Authors: Shah Kaanan , Mabhugu Stella , Obioma Jessica , Nguyen Quang , Schillig Jessica , Torres Brittany P. , Howard Meredith , Lindley Bryn 
Published: November 2024

Background: The 2022 AHA-ACC HFSA Guideline for Management of Heart Failure recommend initiating an angiotensin receptor/neprilysin inhibitor (ARNI) in patients with heart failure with reduced ejection fraction (HFrEF) who can tolerate an angiotensin-converting enzyme inhibitor (ACEi). The manufacturer recommends initiating a 36-hour washout period when switching from ACEi to ARNI due to an increased risk of adverse effects, including angioedema. This study investigated the adherence to the washout period when transitioning from ACEi to ARNI at a community hospital. Objectives: The primary objective was to assess the rate of adherence to the 36-hour washout when transitioning patients from ACEi to ARNI. Secondary outcomes included heart failure exacerbation readmission rates within 90 days and the rate of adverse effects (angioedema, hypotension, acute kidney injury, and hyperkalemia). Methods: This was a retrospective cohort study including patients with HFrEF who were transitioned from ACEi to ARNI during their hospital stay between March 1, 2016 and December 31, 2022. Patients were excluded if they did not receive an ACEi or ARNI during their admission or if they had an ejection fraction >40%. Pearson chi-square was used to analyze categorical data. Results: Of 33 patients included in this study, 67% received the full 36-hour washout period when transitioning from ACEi to ARNI. There were no significant differences between the rates of hospital readmissions or adverse effects between the groups. No patients experienced hyperkalemia or angioedema. Conclusion and Relevance: This is the first study to our knowledge to describe real-world prescribing practices when transitioning patients from ACEi to ARNI for the treatment of HFrEF. Larger, multicenter studies are needed to provide more data on prescribing practices outside this single center. Future research should also include pharmacist’s role in adhering to the recommended washout.
Effects of Mecobalamin on the Functional Outcomes of Complex Regional Pain Syndrome Type 1 of the Foot and Ankle
Authors: Arunakul Marut , Kohkaeng Watcharin , Samornpitakul Pheemaphol , Arunakul Preeyaphan , Kulalert Prapasri , Rachayont Krit 
Published: November 2024

Background: Because of the unclear pathophysiology and the lack of consensus on the gold standard treatment of complex regional pain syndrome (CRPS), management requires a multidisciplinary approach, with the use of various treatment modalities. Nonetheless, no studies have ever been conducted to uncover the potential of mecobalamin as a treatment for CRPS type 1. Hence, the aim of this clinical trial was to evaluate the effects of mecobalamin on the functional outcomes of patients with CRPS type 1 of the foot and ankle, the total amount of pregabalin ingested, and the duration of pregabalin use in each patient. Methods: Forty-seven patients diagnosed with acute CRPS type 1 of the foot and ankle were recruited. Patients were randomly allocated into a control group (23 patients) and a mecobalamin group (24 patients), both receiving similar pain control medications and rehabilitation programs. Three divided doses of mecobalamin 1.5 mg/d were provided to the mecobalamin group for the first 3 months, whereas a placebo was administered to the control group. Data were collected from the pretreatment period, and from 1, 3, 6, and 12 months following the treatment. Results: Both groups had similar demographics. The mean Foot and Ankle Ability Measure (FAAM) activities of daily living (ADL) and FAAM-sport scores in the mecobalamin group at 3 months were 74.5 ± 17.9 and 56.3 ± 22.9, whereas the mean FAAM-ADL and FAAM-sport scores in the placebo group at 3 months were 62.2.5 ± 15.2 and 43.4 ± 14.9, respectively ( P < .05). The 36-Item Short Form Health Survey (SF-36) mental health subscale after 3 months were 83.3 ± 9.5 points and 75.8 ± 12.6 points in the mecobalamin and placebo group, respectively ( P < .05). However, at other time points of assessment (1, 6, and 12 months), the improvement in symptoms was not distinguishable between the 2 groups. Both the amount and duration of total pregabalin required to achieve similar improvements in pain scores were significantly lower in the mecobalamin group than the control group. Conclusion: This small study revealed an improvement of the functional outcomes in patients with CRPS type 1 of the foot and ankle who received mecobalamin instead of a placebo at 3 months that was not sustained at 6 and 12 months. We identified an average 39% total reduction in the amount of total pregabalin used in the mecobalamin group in the first 12 months.
Carboplatin dosing in obese patients
Authors: Ramírez-Roig Cristina , Espuny-Miró Alberto , Olmos-Jiménez Raquel , Díaz-Carrasco María Sacramento 
Published: November 2024

Objectives The study aimed to: 1) Describe the carboplatin dosing criteria in obese patients in routine clinical practicein a general university hospital. 2) Evaluate toxicity based on the dosing criterion used. 3) Assess effectiveness in major diagnoses according to the dosing criterion employed. Methodology An observational, retrospective, descriptive study, including all obese patients (BMI ≥ 30 kg/m2) who started carboplatin treatment between 1st January 2012 and 31st January 2015. Data on patient characteristics, disease and treatment were collected. As a result variables were collected: carboplatin dosing methods, dosage criteria, alternative dosing approaches, treatment delays, dose reductions, relative dose intensity, adverse reactions and severity (CTCAE v. 4.0) as well as overall survival and progressive free survival for major diagnoses. Conclusions 1) Carboplatin dosing at the centre used Calvert's formula for calculating AUC and Cockcroft-Gault's formula for estimating glomerular filtration rate. 2) Cockcroft-Gault's formula employed actual body weight and ideal adjusted body weight in similar proportions. 3) The ideal adjusted body weight was more commonly used in patients with higher obesity and diabetes. 4) In the general population, the developmental trend of toxicity during treatment was greater in the group dosed by actual body weight, reaching significant differences in thrombopenia, neutropenia, GOT elevation, hyporexia and myalgias. 5) Major diagnoses in the present study were ovarian cancer and non-small cell lung cancer. The effectiveness in terms of overall survival and progression-free survival, comparing the groups dosed by actual body weight and ideal adjusted body weight within each pathology did not show statistically significant differences.
Exploring the Relationship of Dietary Intake With Inattention, Hyperactivity, and Impulsivity, Beyond ADHD
Authors: Dalnoki Laura , Hurks Petra P. M. , Gubbels Jessica S. , Eussen Simone J. P. M , Mommers Monique , Thijs Carel 
Published: November 2024

Objectives: This study investigates the association between dietary intake and ADHD diagnosis and its dimensions in adolescents. Methods: In the KOALA Birth Cohort Study, 810 adolescents aged 16 to 20 years provided information on ADHD diagnosis and completed a food frequency questionnaire. Dietary patterns were extracted using Principal Component Analysis. Parents reported on ADHD symptoms using the Conners’ Parent Rating Scale—Revised Short form, and the Impulsivity subscale from the Temperament in Middle Childhood Questionnaire. Results: The 80 adolescents with ADHD scored higher on the Snacking dietary pattern compared to those without ADHD, while they did not differ on Healthy, Animal-based, Sweet, or Beverage dietary patterns. All ADHD symptom scores (Hyperactivity, Inattention and Impulsivity, and ADHD-index) correlated with increased Snacking. Impulsivity was inversely related to Sweet dietary patterns and positively to Beverage dietary patterns. Conclusion: The results highlight the importance of considering ADHD dimensions beyond diagnosis in understanding adolescents’ dietary intake.
Decreased Serum Insulin Receptor Messenger RNA Level in H. pylori IgG Seropositive Type 2 Diabetic Patients
Authors: Tagoe Emmanuel Ayitey , Appiah Jael Acquah , Boateng Pius Agyenim , Quaye Osbourne , Bosomprah Samuel 
Published: November 2024

Background: Helicobacter pylori (H. pylori) is a known gastro-intestinal pathogen but implicated in extra-gastric diseases. The relationship between H. pylori infection and type 2 diabetes (T2DM) remains insufficiently elucidated, particularly in terms of molecular mediators such as microRNAs (miRNAs) and messenger RNAs (mRNAs). Objective: We aimed to characterize expression pattern of insulin signalling mRNAs and targeted miRNAs in T2DM patients exposed to H. pylori infection. Methods: We conducted a cross-sectional study among patients diagnosed with type 2 diabetes mellitus and were aged 18 to 60 years. Overnight fasting blood samples were collected and processed for plasma and serum. The plasma samples were used for glucose estimation and the serum used for H. pylori IgG screening. Total RNA was extracted from the serum with commercial kit, and mRNAs and miRNAs quantified by RT-qPCR with specific primers and under predetermined amplification conditions. Clinical data were obtained from medical records of patients. Results: Among 351 patients enrolled, 267 (76.1%) were females, 224 (63.8%) were married, and 79 (22.5%) had tertiary education. Expression level of insulin receptor mRNA was significantly lower in H. pylori positive T2DM patients compared to H. pylori negative ( P < .05). There was no evidence of a difference in insulin receptor substrate 1 mRNA level ( P > .05). Although not statistically significant, the expression levels of miRNA-222 and miRNA-155 in the patients exposed to H. pylori were higher than that of the unexposed group ( P > .05). Conclusions: We found a significantly reduced serum insulin receptor messenger RNA level and higher levels of miRNA-222 and miRNA-155 in H. pylori exposed T2DM patients. The findings suggest a possible role of the infection in insulin signalling alteration in the patients.