bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Role of Carbon Monoxide in Improving Neurological Outcome After Cardiac Arrest in Aged Rats: Involvement of Inducing Mitochondrial Autophagy
Authors: Wu Jun , Li Yi , Yang Peng , Huang Yaping , Lu Shiqi , Xu Feng 
Published: April 2019

Background

Dysfunctional mitochondria are associated with neurological injury after cardiac arrest (
CA
). Although carbon monoxide (
CO
) has shown various potential therapeutic effects in preclinical tissue injury models, its mechanism of action in
CA
remains unclear. We sought to investigate the effects of a novel
CO
‐releasing molecule on cerebral mitochondrial dysfunction and neurological injury after
CA
.

Methods and Results

Male Sprague‐Dawley rats aged 20 to 22 months were subjected to 6‐minute asphyxia
CA
before receiving
CO
treatment. Survival, neurologic deficit scores, neuronal death, mitochondrial function, and autophagy were evaluated after the return of spontaneous circulation. Results showed
that CO
post‐treatment increased 3‐day survival rate from 25% to 70.83% and reduced neurologic deficit scores.
CO
also ameliorated
CA
‐induced neuronal apoptosis and necrosis in the cerebral cortex and improved cerebral mitochondrial function by reducing reactive oxygen species, reversing mitochondrial membrane potential depolarization, and preventing cytochrome C release. Furthermore,
CO
increased mitochondrial autophagy by inducing mitochondrial accumulation of
PINK
1 (
PTEN
‐induced putative kinase 1) and Parkin. Downregulation of
PINK
1 with genetic silencing si
RNA
abolished
CO
‐afforded mitochondrial autophagy.

Conclusions

Taken together, our results indicate, for the first time, that
CO
treatment confers neuroprotection against ischemic neurological injury after
CA
possibly by promoting mitochondrial autophagy.
Review of the genus Holostaspis Kolenati, 1858 (Acari: Laelapidae)
Authors: BABAEIAN ESMAEIL , MAŠÁN PETER , HALLIDAY BRUCE 
Published: April 2019

Mites in the genus Holostaspis Kolenati, 1858 (Acari: Laelapidae) are usually found in association with ants (Hymenoptera: Formicidae). In this paper we review the genus based on examination of six species from Slovakia, namely H. ambigua sp. nov., H. collina (Huhta & Karg, 2010), H. flexuosa (Michael, 1891) comb. nov., H. isotricha Kolenati, 1858, H. montana (Berlese, 1904) and H. oophila (Wasmann, 1897). We also carried out a careful study of the published work on Holostaspis and related genera, and examined types in the Berlese Acaroteca and other collections. Seven species previously described under the names Hypoaspis (Holostaspis) and Holostaspis are transferred to other genera—H. (H.) brevidentis Karg, 1978 = Pseudoparasitus brevidentis (Karg, 1978) comb. nov., H. (H.) chelaris Teng, Zhang & Cui, 1992 = Euandrolaelaps chelaris (Teng, Zhang & Cui, 1992) comb. nov., H. (H.) metapodalii Karg, 1978 = Gymnolaelaps metapodalii (Karg, 1978) comb. nov., H. mooni Keum, Jung & Joharchi, 2017 = Hypoaspisella mooni (Keum, Jung & Joharchi, 2017) comb. nov., H. (H.) serpentis Karg, 1979 = Hypoaspisella serpentis (Karg, 1979) comb. nov., H. (H.) tridentata Karg, 1979 = Gymnolaelaps tridentatus (Karg, 1979) comb. nov., and Holostaspis (Holostaspis) marginedentatus Trägårdh, 1910 is transferred to Glyptholaspis (Macrochelidae). Based on features of the type specimens (deposited at the Berlese Collection in Florence), the morphological concept of Myrmonyssus (Laelaspulus) acuminatus Berlese, 1903 is revised and the systematic status of the subgenus is re-evaluated. The monobasic Laelaspulus Berlese, 1904 is now removed from synonymy with Myrmozercon Berlese, 1902 and newly considered as a junior synonym of Holostaspis. Another four revised species, originally classified in Laelaps Koch, Myrmozercon Berlese or Hypoaspis Canestrini, are transferred into Holostaspis—L. flexuosa Michael, 1891 = Holostaspis flexuosa (Michael, 1891) comb. nov., M. iranicus Babaeian & Nemati, 2014 = Holostaspis iranica (Babaeian & Nemati, 2014) comb. nov., M. michaeli Joharchi, 2013 = Holostaspis michaeli (Joharchi, 2013) comb. nov., and H. submontana Bai, Gu & Chen, 1994 = Holostaspis submontana (Bai, Gu & Chen, 1994) comb. nov. A complete list of all species formerly classified in Holostaspis is presented, with details of their current placement. An identification key for the species now included in Holostaspis is also provided.
Examination of the Expendable Digital Dropsonde–Derived Vertical Velocities from the Tropical Cyclone Intensity (TCI) Experiment
Authors: Nelson T. Connor , Harrison Lee , Corbosiero Kristen L. 
Published: April 2019

Abstract
The newly developed expendable digital dropsonde (XDD) allows for high spatial and temporal resolution data collection in tropical cyclones (TCs). In 2015, a total of 725 XDDs were launched into Hurricanes Marty (27–28 September), Joaquin (2–5 October), and Patricia (20–23 October) as part of the Tropical Cyclone Intensity (TCI) experiment. These dropsondes were launched from a NASA WB-57 at altitudes above 18 km, capturing the full depth of the TCs to the tropopause. This study documents the vertical velocity distributions observed in TCI using the XDDs and examines the distributions altitudinally, radially, and azimuthally. The strongest mean or median XDD-derived vertical velocities observed during TCI occurred in the upper levels and within the cores of the three TCs. There was little azimuthal signal in the vertical velocity distribution, likely due to sampling asymmetries and noise in the data. Downdrafts were strongest in Joaquin, while updrafts were strongest in Patricia, especially within the eyewall on 23 October. Patricia also had an impressive low-level (&lt;2 km) updraft that exceeded 10 m s−1 associated with a shallow, overturning, radial circulation in the secondary eyewall.
Anthropometric Dimensions of Individuals With High Body Mass Index
Authors: Wiggermann Neal , Bradtmiller Bruce , Bunnell Sue , Hildebrand Cathy , Archibeque John , Ebert Sheila , Reed Matthew P. , Jones Monica L. H. 
Published: April 2019

Objective: This study presents anthropometric data for individuals with high body mass index (BMI). Modified anthropometric dimensions were also developed to address the challenges of obtaining accurate and repeatable data for this population segment. Background: The prevalence of obesity affects approximately 40% of the U.S. adult population. Anthropometric data are needed to guide product design and safety, but few individuals with high BMI have been measured in available datasets. Method: Anthropometric data for a convenience sample of 288 adults with high BMI (≥30 kg/m2) were collected. To increase participation and minimize participant discomfort, measurements were collected at three bariatric weight loss clinics and one academic research institution. Results: The current obese cohort are heavier than the U.S. general population, with a difference in mean body weight of 47 kg for women and 56 kg for men. The obese cohort are also heavier and have a higher BMI compared with the NIOSH (National Institute for Occupational Safety and Health) truck driver population. Waist circumferential measures of the current obese cohort were larger than women or men in either population compared, a result indicative of meaningful body shape differences. Conclusion: To our knowledge, this study is the first to collect anthropometric data for the obese population segment and conduct comparisons to the U.S. general population and available occupational databases. The obese cohort differed substantially with respect to the distributions of anthropometric variables. Application: These data provide insights about the obese population segment that are relevant to product design, and establish a foundation for future data collection efforts.
Effects of parent–child interaction training on children who are excessively exposed to digital devices: A pilot study
Authors: Sadeghi Saeid , Pouretemad Hamid Reza , Khosrowabadi Reza , Fathabadi Jalil , Nikbakht Sedighe 
Published: April 2019

Objective In the last decade, the use of digital devices among children has increased. This study examines the effects of parent–child interaction training on the amount of time children use digital devices, conflict and closeness in parent–child relationships, executive functions, and the electroencephalogram absolute power in children who excessively use the digital devices. Method The sample group consisted of 12 children (24 to 47 months) who spent more than half of their waking hours using digital devices. Parents were trained to intensive interaction with the child for two months. Electroencephalogram absolute power, parent–child interaction, the amount of time children use digital devices, and children’s executive function skills were assessed. Results Parent–child intensive interaction reduces the use of digital devices; decrease the conflicts and increase the closeness in parent–child relationships; decrease executive functioning problems; and increase the absolute power of alpha and alpha 2 (F3), beta 1 (F3), and beta and beta 2 (F3, Fp2). Conclusion These findings provide evidence of the negative effects of the excessive use of digital devices in children, the importance of parent–child interaction, and its positive impacts on cognitive and brain functions in children. It might contribute to better understand the importance of parent–child interaction in the early years.
Design and implementation of a test bed for building controls
Authors: Goyal Siddharth , Wang Weimin , Brambley Michael R 
Published: April 2019

Advanced controls play an essential role toward the improvement of building operational efficiency and the integration of responsive loads in buildings for grid services. Ideally, control algorithms must be sufficiently tested and validated before they are applied on real systems. This paper presents the development and current state of such an evolving test bed to support and enable experiments on advanced controls for buildings. The test bed presented in this paper consists of nine operating buildings—which possess various types of equipment and systems having different control systems and communication mechanisms (e.g., media and protocols) used in building automation systems—on the Pacific Northwest National Laboratory campus. The test bed architecture is developed in such a way that (1) it supports interactions among the buildings and heterogeneous building components and systems, including both virtual and physical devices, e.g., heating, ventilating, and air-conditioning and lighting systems; (2) it can be easily reconfigured for different control topologies and methodologies, e.g., centralized and distributed; (3) it allows selection of communication protocols, communication media, and computation resources; and (4) it is part of a larger cyber-physical test bed that includes both physical and virtual assets on distributed renewable generation, energy storage, and power system assets. Practical application: The test bed presented in this paper can be used by industry to develop and evaluate the performance of advanced control algorithms on real systems for buildings and buildings-to-grid applications. This provides practitioners an opportunity to test the applications and modify them accordingly based on their use cases and selection criteria, e.g., a controller modulating the temperature in a hospital will have different criterion as compared to an office building.
Mice Lacking Brain‐Derived Serotonin Have Altered Swallowing Function
Authors: Haney Megan M. , Sinnott Joseph , Osman Kate L. , Deninger Ian , Andel Ellyn , Caywood Victoria , Mok Alexis , Ballenger Brayton , Cummings Kevin , Thombs Lori , Lever Teresa E. 
Published: April 2019

The intricate sensorimotor neural circuits that control swallowing are heavily reliant on serotonin (5‐hydroxytryptamine [5‐HT]); however, the impact of 5‐HT deficiency on swallow function remains largely unexplored. We investigated this using mice deficient in tryptophan‐hydroxylase‐2 (TPH2), the enzyme catalyzing the rate‐limiting step in 5‐HT synthesis. Videofluoroscopy was utilized to characterize the swallowing function of TPH2 knockout (TPH2‐/‐) mice as compared with littermate controls (TPH2+/+). Results showed that 5‐HT deficiency altered all 3 stages of swallowing. As compared with controls, TPH2‐/‐ mice had significantly slower lick and swallow rates and faster esophageal transit times. Future studies with this model are necessary to determine if 5‐HT replacement may rescue abnormal swallowing function. If so, supplemental 5‐HT therapy may have vast applications for a large population of patients with a variety of neurologic disorders resulting in life‐diminishing dysphagia, particularly amyotrophic lateral sclerosis and Parkinson’s disease, for which 5‐HT deficiency is implicated in the disease pathogenesis.
Intraoperative Imaging with Second Window Indocyanine Green for Head and Neck Lesions and Regional Metastasis
Authors: Stubbs Vanessa C. , Jaffe Samantha , Rajasekaran Karthik , Cannady Steven B. , Shanti Rabie M. , Lee John Y. K. , Newman Jason G. 
Published: April 2019

While optical imaging with near‐infrared (NIR) fluorescent dye has been used in oncologic surgery, its use in the head and neck has not been established. We aimed to evaluate the feasibility of using NIR to visualize primary tumor and regional metastasis in head and neck malignancy. Patients undergoing resection of primary head and neck tumors were included in this pilot study. Each patient was injected with indocyanine green dye (ICG) the day prior to surgery. The VisionSense Iridium camera system was used to visualize the primary lesion, its margins, and neck dissection specimen intraoperatively. Fourteen patients were enrolled. Eighty‐six percent of primary tumors showed fluorescence as compared with surrounding tissues. ICG positivity showed 100% sensitivity for pathologic nodes in 7 neck dissection specimens; however, for 3 patients, nonpathologic nodes also showed ICG positivity. NIR imaging with ICG dye can be considered for intraoperative imaging of head and neck lesions.
Impaired Core Stability as a Risk Factor for the Development of Lower Extremity Overuse Injuries: A Prospective Cohort Study
Authors: De Blaiser Cedric , De Ridder Roel , Willems Tine , Vanden Bossche Luc , Danneels Lieven , Roosen Philip 
Published: April 2019

Background: Core stability has been suggested to influence lower extremity functioning and might contribute to the development of lower extremity overuse injuries. However, prospective studies to investigate this relationship are limited. Purpose: To research the role of different components of core stability as risk factors for the development of lower extremity overuse injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 142 first-year physical education students participated in this study. They were tested in 2015 and were prospectively followed for 1.5 years by means of a multilevel injury registration method. Three participants were excluded owing to physical complaints during testing. As such, 139 participants were included in the statistical analysis. At baseline, dynamic postural control, isometric core and hip muscle strength, core muscle endurance, core neuromuscular control and proprioception, and functional movement were measured for all participants. Competing risk regression analyses were performed to identify significant contributors to the development of lower extremity overuse injuries. Results: During the follow-up period, 34 (24%) of the 139 participants developed a lower extremity overuse injury. Significant predictive effects for an overuse injury were found for an increased side-by-side difference in dynamic postural control ( P = .038), decreased isometric hip extension:flexion strength ratio ( P = .046), and decreased abdominal core muscle endurance ( P = .032). Conclusion: This study identified measures for dynamic postural control, core muscle strength, and core muscle endurance as significant risk factors for the development of overuse injuries after statistical model building. However, core neuromuscular control and proprioception and functional movement might not allow clinicians to identify patients at risk. These accessible, reliable screening tools could be used in clinical practice with regard to screening and injury prevention for overuse injuries. Injury prediction based on this model needs to be done with caution given the low relative predictive accuracy (53%).
A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy
Authors: Hudd Timothy R. , Blake Christie S. , Rimola-Dejesus Yahiada , Nguyen Thu-Trang , Zaiken Kathy 
Published: April 2019

Introduction: Paroxetine is a selective serotonin reuptake inhibitor (SSRI) with several indications, one of which is for depression. We present a case of probable paroxetine-induced serotonin syndrome. Case Summary: A 21-year-old female with a history of generalized anxiety disorder and major depression presented with increased depressive symptoms over several months while taking fluoxetine 20 mg daily. Fluoxetine was discontinued without taper and replaced with paroxetine 10 mg daily, along with hydroxyzine 50 mg twice daily as needed for anxiety. Within a week of starting the paroxetine, the patient reported increased anxiety, insomnia, and constant shaking. The paroxetine continued to be uptitrated over a 3-week period to a dose 30 mg due to unremitting depressive symptoms. One month later, the patient presented with tachycardia, generalized body aches, extreme fatigue, weakness, uncontrollable twitching, tremor, and hyperreflexia. A widespread burning sensation accompanied by random hot flashes without diaphoresis was also noted. Serotonin syndrome was diagnosed using the Hunters criteria. Paroxetine was discontinued, and the patient’s physical symptoms resolved within a week. Discussion: To date, only 5 cases of serotonin syndrome have been reported in patients receiving SSRI monotherapy at recommended therapeutic doses.
Dopamine dysregulation syndrome in non-Parkinson’s disease patients: a systematic review
Authors: Cartoon Jodi , Ramalingam Jothi 
Published: April 2019

Objectives: To explore the presence of dopamine dysregulation syndrome in non-Parkinson’s disease patients receiving dopamine replacement therapy. Methods: Electronic searches were conducted of Medline, Embase, PsycINFO and PreMedline to capture articles related to dopamine misuse or factitious disorder combined with the presence of dopamine replacement therapy or a non-Parkinson’s disease population. In total, 430 articles were reviewed and studies that addressed dopamine dysregulation syndrome in non-Parkinson’s disease patients were included. Results: Nine case reports were identified. Conclusions: The pathophysiology underlying dopamine dysregulation syndrome has been thoroughly explored with numerous mechanisms posited. What remains unclear is whether dopamine dysregulation syndrome is a phenomenon specific to Parkinson’s disease, as indicated in the proposed diagnostic criteria. A more useful predictor of susceptibility to dopamine dysregulation syndrome may be temperamental traits such as novelty seeking and impulsivity, which overlap with predisposing factors for an addiction disorder.
Features of high flow access in the elderly
Authors: Kanno Taro , Kanno Yutaka , Shiroi Kazunari , Kobayashi Nobuhiko , Matsushita Natsumi , Kamishima Kasumi , Hashimoto Koji , Kamijo Yuji 
Published: April 2019

Introduction: The number of elderly hemodialysis patients continues to grow. The aim of this study was to investigate differences in elderly high flow access patients compared with middle-aged and young patients. Methods: We performed a retrospective study to determine the characteristics of elderly patients (aged >60 years) following blood flow suppression procedures. Preoperative and postoperative data from 177 patients who underwent blood flow suppression procedures and 73 patients who underwent procedures for run-off vein ligation and subcutaneous fixation of the superficial artery were compared. Results: A high proportion of young (aged 20–40 years) and middle-aged (aged 41–60 years) patients met the criteria for blood flow suppression procedures (flow volume 1500 mL/min, flow volume/cardiac output 35%), whereas a high proportion of elderly patients did not. Moreover, heart strain could evidently be caused even with low flow volume. In elderly patients, a tricuspid regurgitation pressure gradient and right heart strain were observed more frequently. Conclusion: Elderly patients who underwent blood flow suppression procedures or subcutaneous fixation of the superficial artery exhibited lower flow volume, and the effects of high flow access in elderly patients depend on the nature of vascular changes. Ultimately, the underlying conditions and hemodynamics of each patient must be determined on an individual basis.
Palliative care for people with non-malignant respiratory disease and their carers: a review of the current evidence
Authors: Mc Veigh Clare , Reid Joanne , Larkin Philip , Porter Sam , Hudson Peter 
Published: April 2019

Background Internationally, non-malignant respiratory disease is on the increase. However, although palliative care is recommended as an appropriate healthcare option for this client group, evidence suggests that these patients and their carers do not receive the same standards of palliative care as patients with a malignant lung condition. Aim The aim of this review was to provide a critical overview of the current evidence base in relation to the palliative service provision for people with non-malignant respiratory disease and their carers. Methods A review of the literature was conducted in July 2015 and updated in October 2017 and focused on the palliative care service provision for patients with interstitial lung disease, chronic obstructive pulmonary disease and bronchiectasis. Results In total, 71 empirical studies were included in the review and grouped into two main themes: patient and carer’s bio-psychosocial symptom needs and management, and palliative care service provision for patients with non-malignant respiratory disease and their carers. Conclusion The majority of palliative research focuses on patients with a diagnosis of chronic obstructive pulmonary disease. A deeper insight is required into the palliative service provision experienced by those with other forms of non-malignant respiratory disease such as bronchiectasis and interstitial lung disease.
Measurement of thumb pronation and palmar abduction angles with a small motion sensor: a comparison with Kapandji scores
Authors: Kuroiwa Tomoyuki , Nimura Akimoto , Suzuki Shiro , Sasaki Toru , Okawa Atsushi , Fujita Koji 
Published: April 2019

The Kapandji score is used widely to record thumb opposition and is the only alternative to angular measurements. We aimed to verify the extent to which the Kapandji score reflects the angle of pronation. We recruited volunteers with unaffected upper limbs (33 hands) and patients with carpal tunnel syndrome (20 hands). We attached a small gyroscope to the thumb metacarpal and measured the pronation and palmar abduction angles at each position of the Kapandji score in both groups. The Kapandji score showed a strong ceiling effect, and the increase in angle size at each Kapandji score levelled off around a score of 6 in both groups. A Kapandji score greater than 6 does not necessarily reflect thumb opposition. Level of Evidence: III