bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criteria for return to running after anterior cruciate ligament reconstruction: a scoping review
Authors: Rambaud Alexandre J M , Ardern Clare L , Thoreux Patricia , Regnaux Jean-Philippe , Edouard Pascal 
Published: May 2018

ObjectiveTo describe the criteria used to guide clinical decision-making regarding when a patient is ready to return to running (RTR) after ACL reconstruction.DesignScoping review.Data sourcesThe MEDLINE (PubMed), EMBASE, Web of Science, PEDro, SPORTDiscus and Cochrane Library electronic databases. We also screened the reference lists of included studies and conducted forward citation tracking.Eligibility criteria for selecting studiesReported at least one criterion for permitting adult patients with primary ACL reconstruction to commence running postoperatively.Results201 studies fulfilled the inclusion criteria and reported 205 time-based criteria for RTR. The median time from when RTR was permitted was 12 postoperative weeks (IQR=3.3, range 5–39 weeks). Fewer than one in five studies used additional clinical, strength or performance-based criteria for decision-making regarding RTR. Aside from time, the most frequently reported criteria for RTR were: full knee range of motion or >95% of the non-injured knee plus no pain or pain <2 on visual analogue scale; isometric extensor limb symmetry index (LSI)>70% plus extensor and flexor LSI>70%; and hop test LSI>70%.ConclusionsFewer than one in five studies reported clinical, strength or performance-based criteria for RTR even though best evidence recommends performance-based criteria combined with time-based criteria to commence running activities following ACL reconstruction.
Subjects with cardiovascular disease or high disease risk are more sedentary and less active than their healthy peers
Authors: Vasankari Ville , Husu Pauliina , Vähä-Ypyä Henri , Suni Jaana Helena , Tokola Kari , Borodulin Katja , Wennman Heini , Halonen Jari , Hartikainen Juha , Sievänen Harri , Vasankari Tommi 
Published: May 2018

ObjectivesWe investigated differences in objectively measured sedentary behaviour (SB) and physical activity (PA) levels in subjects with cardiovascular disease (CVD) diagnosis or high CVD risk compared with healthy controls.MethodsThe present study includes a subsample (n=1398, Health 2011 Study) of participants, who attended health examinations and wore a triaxial accelerometer (≥4 days). Patients with CVD were identified and CVD risk was calculated for others using Framingham Risk Score (FRS). Participants were categorised into groups: FRS<10%; FRS=10%–30%; FRS>30%/CVD. Raw acceleration data were analysed with mean amplitude deviation (MAD) and angle for posture estimation (APE). MAD corresponding to intensity of PA was converted to metabolic equivalents (MET) and categorised to light (1.5–2.9 METs) and moderate to vigorous PA (MVPA≥3.0 METs). APE recognises SB and standing.ResultsDaily accumulated time of >30 s MVPA bouts was higher in FRS<10% group (46 min) than in FRS>30%/CVD group (29 min) (p<0.001). FRS>30%/CVD group were more sedentary, their mean daily number of >10 min SB bouts (13.2) was higher than in FRS <10% group (11.5) (p=0.002).ConclusionNumber and accumulated times of SB and PA bouts differed between the CVD risk groups. Causative research is required to assess the importance of SB and PA in prevention and rehabilitation of CVDs.
Smad4/DPC4
Authors: McCarthy Aoife J , Chetty Runjan 
Published: May 2018

Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-β) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation ofsmad4/DPC4is best recognised in pancreatic cancer. However,smad4/DPC4is also mutated in other conditions and cancers such as juvenile polyposis syndrome with and without hereditary haemorrhagic telangiectasia, colorectal and prostate cancers.Immunohistochemistry for smad4/DPC4 protein is most useful in separating benign/reactive conditions from pancreatic cancer in needle/core biopsies. In normal and reactive states, the protein is localised to the cytoplasm and nucleus, while the protein is lost in high-grade pancreatic intraepithelial neoplasia/carcinoma in situ and pancreatic cancer.
Access to radical resections of pancreatic cancer is region-dependent despite the public healthcare system in Finland
Authors: Ahola Reea , Hölsä Heini , Kiskola Samuli , Ojala Pirkka , Pirttilä Aino , Sand Juhani , Laukkarinen Johanna 
Published: May 2018

BackgroundSurgical resection is the best treatment option to improve the prognosis of pancreatic cancer (PC). Our aim was to analyse whether PC treatment strategies show regional variation in Finland, a country with a nationwide public healthcare system.MethodsAll patients diagnosed with PC in 2003 and 2008 were identified from the Finnish Cancer Registry. The data regarding tumour, treatment, demographics and timespans to treatment were recorded from the patient archives. Patients were included in the healthcare district where the diagnosis was made. The healthcare districts were classified according to experience in pancreatic surgery into three groups (high level of experience region (HLER), n=2; medium level of experience region (MLER), n=6, and low level of experience region (LLER), n=13).ResultsPatients included numbered 1546 (median age 72 years (range 34–97), 45% men). Demographics and the ratio of stage IV disease (53%) were similar between the regional groups. Despite this, the proportion of radical surgery was greater in HLERs than in the MLERs and LLERs (18% vs 8%–11%; p<0.01). Logistic regression analysis including age, American Society of Anesthesiologists classification, stage and level of experience showed that more radical resections were performed in the HLERs. Preoperative bile drainage showed no regional differences (p=0.137). Palliative chemotherapy only was used more frequently in MLER and LLER than in HLERs (24% vs 33%–30%; p<0.01).ConclusionAccess to PC curative treatment was more likely for patients in healthcare districts including a hospital with high level of experience in pancreatic surgery. This highlights the importance of centralized treatment guidance.
Rates of pelvic inflammatory disease and ectopic pregnancy in Australia, 2009–2014: ecological analysis of hospital data
Authors: Goller Jane L , De Livera Alysha M , Guy Rebecca, J , Low Nicola , Donovan Basil , Law Matthew , Kaldor John M , Fairley Christopher K , Hocking Jane S 
Published: May 2018

ObjectiveTo analyse yearly rates of pelvic inflammatory disease (PID) and ectopic pregnancy (EP) diagnosed in hospital settings in Australia from 2009 to 2014.MethodsWe calculated yearly PID and EP diagnosis rates in three states (Victoria, New South Wales, Queensland) for women aged 15–44 years using hospital admissions and emergency department (ED) attendance data, with population and live birth denominators. We stratified PID diagnoses as chlamydial-related or gonorrhoeal-related (Chlamydia trachomatis (CT)-related or Neisseria gonorrhoeae (NG)-related), acute, unspecified and chronic, and analysed variations by year, age and residential area using Poisson regression models.ResultsFor PID, the rate of all admissions in 2014 was 63.3 per 100 000 women (95% CI 60.8 to 65.9) and of all presentations in EDs was 97.0 per 100 000 women (95% CI 93.9 to 100.2). Comparing 2014 with 2009, the rate of all PID admissions did not change, but the rate of all presentations in EDs increased (adjusted incidence rate ratio (aIRR) 1.34, 95% CI 1.24 to 1.45), and for admissions by PID category was higher for CT-related or NG-related PID (aIRR 1.73, 95% CI 1.31 to 2.28) and unspecified PID (aIRR 1.09, 95% CI 1.00 to 1.19), and lower for chronic PID (aIRR 0.84, 95% CI 0.74 to 0.95). For EP, in 2014 the rate of all admissions was 17.4 (95% CI 16.9 to 17.9) per 1000 live births and of all ED presentations was 15.6 (95% CI 15.1 to 16.1). Comparing 2014 with 2009, the rates of all EP admissions (aIRR 1.06, 95% CI 1.04 to 1.08) and rates in EDs (aIRR 1.24, 95% CI 1.18 to 1.31) were higher.ConclusionsPID and EP remain important causes of hospital admissions for female STI-associated complications. Hospital EDs care for more PID cases than inpatient departments, particularly for young women. Updated primary care data are needed to better understand PID epidemiology and healthcare usage.
Assessing genetic diversity of various Canadian sheep breeds through pedigree analyses
Authors: Stachowicz Katarzyna , Brito Luiz F. , Oliveira Hinayah R. , Miller Stephen P. , Schenkel Flávio S. 
Published: May 2018

The loss of genetic variability in a population will drastically affect the success of a breeding program by reducing selection response and fitness and, consequently, affecting reproduction, resilience, and production efficiency. The objective of this study was to perform an in-depth analysis of the pedigree of the Canadian sheep breeds to assess the levels of inbreeding, effective population size, and other metrics of genetic diversity, which included the five most important sheep breeds in Canada: Dorset, Polypay (PO), Rideau-Arcott, Romanov (RV), and Suffolk, using a large dataset (1 336 926 animals). As measures of genetic diversity, effective population size, inbreeding coefficient, effective number of founders, effective number of founder genomes, effective number of nonfounders, and effective number of ancestors were estimated. The completeness and depth of the Canadian sheep pedigree datasets were reasonably high, with <20% parental information missing. More attention should be given to PO breed, which was found to have the smallest effective population size (55), and RV breed, which had the highest average level of inbreeding (4.8%). Techniques such as optimum contribution selection and minimum coancestry mating could be used to minimize the inbreeding of future generations, while maintaining genetic progress at a desirable level.
Compression of a mixed antiproton and electron non-neutral plasma to high densities
Authors: Aghion Stefano , Amsler Claude , Bonomi Germano , Brusa Roberto S. , Caccia Massimo , Caravita Ruggero , Castelli Fabrizio , Cerchiari Giovanni , Comparat Daniel , Consolati Giovanni , Demetrio Andrea , Di Noto Lea , Doser Michael , Evans Craig , Fanì Mattia , Ferragut Rafael , Fesel Julian , Fontana Andrea , Gerber Sebastian , Giammarchi Marco , Gligorova Angela , Guatieri Francesco , Haider Stefan , Hinterberger Alexander , Holmestad Helga , Kellerbauer Alban , Khalidova Olga , Krasnický Daniel , Lagomarsino Vittorio , Lansonneur Pierre , Lebrun Patrice , Malbrunot Chloé , Mariazzi Sebastiano , Marton Johann , Matveev Victor , Mazzotta Zeudi , Müller Simon R. , Nebbia Giancarlo , Nedelec Patrick , Oberthaler Markus , Pacifico Nicola , Pagano Davide , Penasa Luca , Petracek Vojtech , Prelz Francesco , Prevedelli Marco , Rienaecker Benjamin , Robert Jacques , Røhne Ole M. , Rotondi Alberto , Sandaker Heidi , Santoro Romualdo , Smestad Lillian , Sorrentino Fiodor , Testera Gemma , Tietje Ingmari C. , Widmann Eberhard , Yzombard Pauline , Zimmer Christian , Zmeskal Johann , Zurlo Nicola , Antonello Massimiliano 
Published: May 2018

Abstract

We describe a multi-step “rotating wall” compression of a mixed cold antiproton–electron non-neutral plasma in a 4.46 T Penning–Malmberg trap developed in the context of the AEḡIS experiment at CERN. Such traps are routinely used for the preparation of cold antiprotons suitable for antihydrogen production. A tenfold antiproton radius compression has been achieved, with a minimum antiproton radius of only 0.17 mm. We describe the experimental conditions necessary to perform such a compression: minimizing the tails of the electron density distribution is paramount to ensure that the antiproton density distribution follows that of the electrons. Such electron density tails are remnants of rotating wall compression and in many cases can remain unnoticed. We observe that the compression dynamics for a pure electron plasma behaves the same way as that of a mixed antiproton and electron plasma. Thanks to this optimized compression method and the high single shot antiproton catching efficiency, we observe for the first time cold and dense non-neutral antiproton plasmas with particle densities n ≥ 1013 m−3, which pave the way for an efficient pulsed antihydrogen production in AEḡIS.

Graphical abstract
Measurements of the Reactor Antineutrino with Solid State Scintillation Detector
Authors: Alekseev I. , Belov V. , Brudanin V. , Danilov M. , Egorov V. , Filosofov D. , Fomina M. , Hons Z. , Kazartsev S. , Kobyakin A. , Kuznetsov A. , Machikhiliyan I. , Medvedev D. , Nesterov V. , Olshevsky A. , Pogorelov N. , Ponomarev D. , Rozova I. , Rumyantseva N. , Rusinov V. , Salamatin A. , Samigullin E. , Shevchik Ye. , Shirchenko M. , Shitov Yu. , Skrobova N. , Starostin A. , Svirida D. , Tarkovsky E. , Tikhomirov I. , Vlášek J. , Zhitnikov I. , Zinatulina D. 
Published: May 2018

Measurements of reactor antineutrino play an important role in the efforts at the frontier of the modern physics. The DANSS collaboration presents preliminary results of a one year run with a cubic meter solid state detector placed below 3.1 GW industrial light water reactor. The experiment is sensitive to sterile neutrino in the most interesting region of mixing parameter space. 2500 scintillation strips of the sensitive volume of the detector have multilayer passive shielding of copper, lead and borated polyethylene and active muon veto. Detector position below the reactor gives an advantage of overburden about 50 m of water equivalent providing factor of six in cosmic muon suppression and eliminating fast neutrons.The detector is placed on a vertically movable platform which allows to change the distance to the reactor core center in the range 10.7-12.7 m within a few minutes. The strips are read out individually by SiPMs and in groups of 50 by PMTs. 5000 inverse beta-decay events per day are collected in the fiducial volume, which is 78% of the whole detector, at the position closest to the reactor. Overburden, active veto and good segmentation of the detector result in an excellent signal to background ratio. The talk is dedicated to the data analysis and preliminary results. The experiment status is also presented.
Top Quark Mass and Properties Measurements with the ATLAS Detector
Authors: Moreno Llácer M. 
Published: May 2018

The top quark is the heaviest elementary particle and unique among the known quarks since it decays before forming hadronic bound states. This makes measurements of the top quark itself particularly interesting as one can access directly the properties of a bare quark. The latest measurements of these properties with the ATLAS detector are reported using data from 8 TeV and 13 TeV proton-proton collisions at the Large Hadron Collider at CERN. The latest measurements of the top quark mass using template methods, as well as others aiming to measure the mass in a well-defined scheme, are presented. In addition, measurements for the top quark decay width, top quark spin observables and [Formula: see text]-boson helicity in events with top quark pairs ([Formula: see text]) are presented and compared to the Standard Model predictions. The cross-section measurements of top quark pair production in association with a photon, [Formula: see text]- or [Formula: see text]-boson are also reported and compared to the most accurate theoretical calculations. These measurements probe the top quark electroweak couplings. Limits on the rate of flavour-changing neutral current processes in the production or decay of the top quark are also shown.
Measurements of Properties of Antihydrogen
Authors: Olin Art ,   M. Ahmadi, B.X.R. Alves, C.J. Baker, W. Bertsche, E. Butler, A. Capra, C. Carruth, A.E. Charman, L.T. Evans, C.L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, L.T. Evans, N. Evetts, J. Fajans, T. Friesen, M.C. Fujiwara, D.R. Gill, J.S. Hangst, W.N. Hardy, M.E. Hayden, C.A. Isaac, M.A. Johnson, J.M Jones, S.A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J.T.K. McKenna, S.Menary, T. Momose, J.J. Munich, K. Olchanski, A. Olin, P. Pusa, C. Rasmussen, F.
Published: May 2018

The ALPHA project at the CERN AD is testing fundamental symmetries between matter and antimatter using trapped antihydrogen atoms. The spectrum of the antihydrogen atom may be compared to ordinary hydrogen where it has been measured very precisely. CPT conservation, which underpins our current theoretical framework, requires equality of the masses and charges of matter and its antimatter partners, so antihydrogen spectroscopy presents a path to precision CPT tests. I will discuss the techniques used by ALPHA to trap more than 8000 antihydrogen atoms in 2016, and interrogate them for 600s. The 1S-2S transition in antihydrogen has been observed for the first time, and it agrees with its hydrogen counterpart within an uncertainty of 400 kHz or 0.2 ppb. The charge of the antihydrogen atom has been bounded below [Formula: see text]. A value of 1420.4 0.5MHz for the hyperfine splitting has been obtained from observation of the positron spin resonance spectrum.
3D numerical modelling of the Wilson cycle: structural inheritance of alternating subduction polarity
Authors: Beaussier Stéphane J. , Gerya Taras V. , Burg Jean-Pierre 
Published: May 2018

Abstract
Alternating subduction polarity along suture zones has been documented in several orogenic systems. Yet the mechanisms leading to this geometric inversion and the subsequent interplay between the contra-dipping slabs have been little studied. To explore such mechanisms, 3D numerical modelling of the Wilson cycle was conducted from continental rifting, breakup and oceanic spreading to convergence and self-consistent subduction initiation. In the resulting models, near-ridge subduction initiating with the formation of contra-dipping slab segments is an intrinsically 3D process controlled by earlier convergence-induced ridge swelling. The width of the slab segments is delimited by transform faults inherited from the rifting and ocean floor spreading stages. The models show that the number of contra-dipping slab segments depends mainly on the size of the oceanic basin, the asymmetry of the ridge and variations in kinematic inversion from divergence to convergence. Convergence velocity has been identified as a second-order parameter. The geometry of the linking zone between contra-dipping slab segments varies between two end-members governed by the lateral coupling between the adjacent slab segments: (1) coupled slabs generate wide, arcuate linking zones holding two-sided subduction; and (2) decoupled slabs generate narrow transform fault zones against which one-sided, contra-dipping slabs abut.
Reappraisal of the magma-rich versus magma-poor rifted margin archetypes
Authors: Tugend Julie , Gillard Morgane , Manatschal Gianreto , Nirrengarten Michael , Harkin Caroline , Epin Marie-Eva , Sauter Daniel , Autin Julia , Kusznir Nick , McDermott Ken 
Published: May 2018

Abstract
Rifted margins are commonly defined as magma-poor or magma-rich archetypes based on their morphology. We re-examine the prevailing model inferred from this classification that magma-rich margins have excess decompression melting at lithospheric breakup compared with steady-state seafloor spreading, while magma-poor margins have inhibited melting. We investigate the magmatic budget related to lithospheric breakup along two high-resolution long-offset deep reflection seismic profiles across the SE Indian (magma-poor) and Uruguayan (magma-rich) rifted margins.
Resolving the magmatic budget is difficult and several interpretations can explain our seismic observations, implying different mechanisms to achieve lithospheric breakup and melt production for each archetype. We show that the Uruguayan and other magma-rich margins may indeed involve excess decompression melting compared with steady-state seafloor spreading but could also be explained by a gradual increase with an early onset relative to crustal breakup. A late onset of decompression melting relative to crustal breakup enables mantle exhumation characteristic of magma-poor margin archetypes (e.g. SE India).
Despite different volumes of magmatism, the mechanisms suggested at lithospheric breakup are comparable between both archetypes. Considerations on the timing of decompression melting onset relative to crustal thinning may be more important than the magmatic budget to understand the evolution and variability of rifted margins.
Interspike interval analysis and spikelets in presubicular head-direction cells
Authors: Coletta Stefano , Zeraati Roxana , Nasr Khaled , Preston-Ferrer Patricia , Burgalossi Andrea 
Published: May 2018

Head-direction (HD) neurons are thought to provide the mammalian brain with an internal sense of direction. These cells, which selectively increase their firing when the animal’s head points in a specific direction, use the spike rate to encode HD with a high signal-to-noise ratio. In the present work, we analyzed spike train features of presubicular HD cells recorded juxtacellularly in passively rotated rats. We found that HD neurons could be classified into two groups on the basis of their propensity to fire spikes at short interspike intervals. “Bursty” neurons displayed distinct spike waveforms and were weakly but significantly more modulated by HD compared with “nonbursty” cells. In a subset of HD neurons, we observed the occurrence of spikelets, small-amplitude “spike-like” events, whose HD tuning was highly correlated to that of the co-recorded juxtacellular spikes. Bursty and nonbursty HD cells, as well as spikelets, were also observed in freely moving animals during natural behavior. We speculate that spike bursts and spikelets might contribute to presubicular HD coding by enhancing its accuracy and transmission reliability to downstream targets. NEW & NOTEWORTHY We provide evidence that presubicular head-direction (HD) cells can be classified into two classes (bursty and nonbursty) on the basis of their propensity to fire spikes at short interspike intervals. Bursty cells displayed distinct electrophysiological properties and stronger directional tuning compared with nonbursty neurons. We also provide evidence for the occurrence of spikelets in a subset of HD cells. These electrophysiological features (spike bursts and spikelets) might contribute to the precision and robustness of the presubicular HD code.