bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levantite, KCa3(Al2Si3)O11(PO4), a new latiumite-group mineral from the pyrometamorphic rocks of the Hatrurim Basin, Negev Desert, Israel
Authors: Galuskin Evgeny V. , Krüger Biljana , Galuskina Irina O. , Krüger Hannes , Vapnik Yevgeny , Pauluhn Anuschka , Olieric Vincent 
Published: June 2019

AbstractLevantite, with the end-member formula KCa3(Al2Si3)O11(PO4), is the phosphate analogue of latiumite, KCa3(Al3Si2)O11(SO4, CO3) found in gehlenite–wollastonite hornfels on Har Parsa, Negev Desert, Israel. Levantite forms later zones on long-prismatic crystals of latiumite. Rarer homogeneous colourless levantite crystals up to 0.2 mm long and with mean composition (K0.94Ba0.01Na0.01□0.04)Σ1.00(Ca2.96Mg0.03)Σ2.99{(Si2.69Al2.06Fe3+0.16P0.06)Σ4.97O11}[(PO4)0.65(SO4)0.35]Σ1.00were noted. Minerals of the levantite–latiumite series are associated with gehlenite, wollastonite, clinopyroxene of the esseneite–diopside series, anorthite and Ti-bearing andradite. Levantite crystalises in space groupP21with unit-cell parametersa= 12.1006(9) Å,b= 5.1103(4) Å,c= 10.8252(9) Å, β = 107.237(8)°,V= 639.34(9) Å3andZ= 2. The structure of levantite is analogous to latiumite. It is formed by tetrahedral hybridzweierdouble layers [(Si,Al)10O22] connected by Ca atoms. Three Ca atoms linked to different double layers are bridged over by (PO4) and minor (SO4) groups. K atoms reside in the cavities between two superimposedzweierdouble layers. The measured micro-indentation hardness of levantite gave VHN50= 580(19) (mean of 14), range 550–611 kg/mm2, which correlates with 5 on the Mohs scale. Cleavage is good on (100). Twinning on (100) is polysynthetic or simple. The calculated density is 2.957 g cm–3. Levantite is optically negative with α = 1.608(2), β = 1.618(2), γ = 1.622(2) (λ = 589 nm), 2Vmeas.= 70(5)° and 2Vcalc.= 64.3°. Dispersion of the optical axes r > v is weak; the optical orientation is:Z=b,X^c= 22–27°; and it is non-pleochroic. Minerals of the levantite–latiumite series from Israel show characteristic Raman spectra with the main bands at 994 cm–1[ν1(SO4)2–] and 945 cm–1[ν1(PO4)3–]. The band intensity ν1(PO4)3–/ν1(SO4) ratio is well correlated with P and S contents in the investigated minerals. The strongest lines in the powder diffraction pattern [dobs, Å (I, %) (hkl)] are: 3.0762(100)(310), 2.8551(96)($\bar 2$13), 2.9704(92)($\bar 3$12), 2.8573(83)(013), 2.5552(66)(020), 2.8228(48)(212), 2.8893(40)(400), and 3.0634(30)(103).
USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
Authors: Man Xiaojun , Piao Chiyuan , Lin Xuyong , Kong Chuize , Cui Xiaolu , Jiang Yuanjun 
Published: June 2019

Abstract
Background
USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

Methods
q-RT-PCR was performed to examine the expression of miR-130b-3p, miR-301b-3p and USP13 in BC tissue samples. Western blot, q-RT-PCR, bioinformatic analysis and dual-luciferase reporter assay were conducted to identify the regulatory function of miR-130b-3p/301b-3p for USP13. Co-immunoprecipitation assay was performed to assess the interaction between USP13 and PTEN protein. Cell-counting-kit 8, colony formation assay and transwell assay were performed to value the proliferative, migrative and invasive capacities of BC cells in vitro. Mouse xenograft model of BC cells was established to verify the function of USP13 in vivo. Immunohistochemistry was performed to identify the protein expression of USP13, NF-kB p65 or PTEN in clinical/xenograft tumor tissues.

Results
Our present study reveals that USP13 functions as a tumor suppressor by interacting with PTEN protein and increasing its expression in bladder cancer. We found that loss of USP13 led to the downregulation of PTEN and promoted proliferative, invasive and migrative capacities of bladder cancer cells. Furthermore, we discovered that USP13 was a common target of miR-130b-3p and miR-301b-3p, and the miR-130b/301b cluster, which could be transcriptionally upregulated by NF-kB. Our data demonstrated that NF-kB activation decreased expression level of USP13 and PTEN, and promoted the tumorigenesis phenotypes of BC cells. In addition, reintroduction of USP13 partially rescued PTEN expression as well as the oncogenesis trend caused by NF-kB.

Conclusion
We reported a potential regulatory loop that the NF-kB-induced miR-130b/301b overexpression decreased USP13 expression and subsequently resulted in the downregulation of PTEN protein and promoted tumorigenesis of bladder cancer. Moreover, NF-kB-mediated PTEN downregulation is very likely to facilitate the full activation of NF-kB.
Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells
Authors: Rossi Jean‐François , Céballos Patrice , Lu Zhao‐Yang 
Published: June 2019

AbstractCancer cell growth is associated with immune surveillance failure. Nowadays, restoring the desired immune response against cancer cells remains a major therapeutic strategy. Due to the recent advances in biological knowledge, efficient therapeutic tools have been developed to support the best bio‐clinical approaches for immune precision therapy. One of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies, particularly the use of rituximab for B‐cell lymphoproliferative disorders. More recently, other monoclonal antibodies have been developed, to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression, or to enhance some immune functions with immune adjuvants through different targets such as Toll‐receptor agonists. The aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse effects. This effect is supported by enhancing the number, functions, and activity of the immune effector cells, including the natural killer (NK) lymphocytes, NKT‐lymphocytes, γδ T‐lymphocytes, cytotoxic T‐lymphocytes, directly or indirectly through vaccines particularly with neoantigens, and by lowering the functions of the immune suppressive cells. Beyond these new therapeutics and their personalized usage, new considerations have to be taken into account, such as epigenetic regulation particularly from microbiota, evaluation of transversal functions, particularly cellular metabolism, and consideration to the clinical consequences at the body level. The aim of this review is to discuss some practical aspects of immune therapy, giving to clinicians the concept of immune effector cells balancing between control and tolerance. Immunological precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.
Circulating Exosomes Activate Dendritic Cells and Induce Unbalanced CD4+ T Cell Differentiation in Hashimoto Thyroiditis
Authors: Cui Xuejiao , Liu Yongping , Wang Shuo , Zhao Na , Qin Jing , Li Yushu , Fan Chenling , Shan Zhongyan , Teng Weiping 
Published: June 2019

AbstractObjectiveThis study explored whether circulating exosomes effectively participate in the inflammatory response in Hashimoto thyroiditis (HT).DesignExosomes were extracted from the serum of 30 patients with HT and 30 healthy control (HC) subjects. The expression of thyroperoxidase (TPO), thyroglobulin, high mobility group box 1 (HMGB1), heat shock protein 60 (HSP60), major histocompatibility complex class II (MHC-II), and intercellular adhesion molecule 1 (ICAM1) in exosomes was determined by Western blotting. Flow cytometry and immunofluorescence were performed to confirm that exosomes were taken up by healthy peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs). Then, either DCs or PBMCs were stimulated with HT exosomes (serum exosomes from patients with HT) or HC exosomes (serum exosomes from HC subjects) in the presence or absence of Toll-like receptor (TLR)2/3 inhibitors.ResultsTPO, HSP60, and MHC-II expression was higher in HT exosomes than in HC exosomes. Exosomes were mainly taken up by CD14+ monocytes and CD11c+ DCs. After DCs were stimulated by HT exosomes, significant elevations were observed in MyD88, TRIF, and p-P65 expression; median fluorescence intensity of CD40 and CD83; and IL-6 production. After stimulating PBMCs with HT exosomes, CD11c+TLR2+/TLR3+ and CD4+IFN-γ+Th1/IL-17A+Th17A cell percentages were significantly elevated, and CD4+CD25+Foxp3+ Treg cell percentage was significantly decreased. HT exosomes induced increased IL-17A and IFN-γ production, whereas IL-10 production was suppressed. However, addition of TLR2 or TLR3 inhibitor reversed most of the abovementioned results.ConclusionsOur study demonstrates that HT exosomes can present antigens to DCs and bind TLR2/3, causing DC activation via the nuclear factor κB signaling pathway, leading to an imbalance in CD4+ T lymphocyte differentiation, and potentially contributing to HT onset.
Protestant Buddhism and “Influence”
Authors: Abeysekara Ananda 
Published: June 2019

AbstractCritiques of the concept of “Protestant Buddhism” claim to tell a different story about the relation between religion and modernity (“Protestantism”) in South Asia. They seek to reconstruct the temporal relation between the past and the present, contesting postcolonial conceptions of history, time, and religious practice. This story of temporality is staked on the question of “influence,” which has a genealogy that includes not just colonial, missionary, liberal politics but also contemporary legal-political questions about foreign influence on democracy and sovereignty. This article argues that preoccupation with influence inscribes an a priori ontology that already separates the past from the present. This makes it difficult to understand the relation between temporality and a form of life in a discursive tradition, as the question of influence grounds the ostensive plurality of religions in some preexisting ontological difference. Once religion as such is understood as an object of influence, the temporality of the form, which is encountered within power—that is, the formations of particular sensibilities and dispositions within the coherence of a tradition—is rendered marginal if not irrelevant to the embodied life of religion. The article calls for renewed attention to the temporality of sensibilities to think about the temporality of a form of life within the limits of a tradition.
Proust’s Natural History Museum
Authors: Crawford Ryan 
Published: June 2019

Abstract
This essay takes the last pages of Marcel Proust’s In Search of Lost Time at its word: at the moment the narrator achieves a definitive conception of the work he intends to write, he sees society composed, not of people of flesh and blood, but of monsters fit for a museum of natural history. As the novel culminates in images and concepts that are essentially nonhuman, inhuman, or posthuman in character, it demonstrates an exacting knowledge of what the present is only now beginning to realize: after two world wars and humanity’s recent entry into what is called the age of the Anthropocene, certain fundamental relations (between subject and object, between nature and history, between past, present, and future) must be rethought to account for both the eclipse of the human as well as nature’s ultimate survival. This essay seeks to develop a philosophical form that would approximate the novel’s discovery of this posthuman natural history.
Prelacteal feeding practice and maintenance of exclusive breast feeding in Bihar, India – identifying key demographic sections for childhood nutrition interventions: a cross-sectional study
Authors: Das Aritra , Sai Mala Guntur , Singh Ram Shankar , Majumdar Amlan , Chatterjee Rahul , Chaudhuri Indrajit , Mahapatra Tanmay 
Published: June 2019

Background: Exclusive breastfeeding (EBF) during the first six months of life is considered a high impact, but low-cost, measure for improving nutritional status, and reducing morbidity and mortality among children. However, providing prelacteal feed to a newborn, a widely practiced custom in rural India, is a major barrier to the practice of EBF. The present study evaluated the association between provision of prelacteal feeding and continuation of EBF among children up to 3 months age in Bihar, a resource-poor Indian state. Methods: Data from four rounds of a population-based multi-stage sampling survey, conducted in 8 districts of Bihar between 2012 and 2013, were used for the present analysis. Using simple and adjusted logistic regression modelling, we tested the association of providing prelacteal feeding with two outcome measures - 1) giving only breastmilk during the last 24 hours, and 2) exclusively breastfed (EBF) since birth (excluding the first 3 days of life). Results: Among 10,262 children for whom prelacteal feeding data was available, 26% received prelacteal feeding. About 55% mothers reported that their children were exclusively breastfed, whereas 82% mothers provided only breastmilk to their children during the previous 24 hours. Children who received prelacteal feeding had approximately 60% lesser odds of being breastfed exclusively during the previous 24 hours [AOR = 0.39(0.33-0.47)] and 80% lesser odds of receiving continued EBF since birth [AOR = 0.20(0.17-0.24)]. Conclusions: Frontline workers (FLW) provide nutritional counselling to mothers and children of rural India. In order to improve uptake of EBF, the families practicing prelacteal feeding should be identified early and educated on the harmful effects of prelacteal feeding for EBF and subsequently on infant health. Midwives/nurses at the public and private facilities as well as the home birth attendants should also be made aware about the negative effects of prelacteal feed.
Jak (wy)tłumaczyć punkt widzenia kota?
Authors: Jeleń Krzysztof 
Published: June 2019

How to Explain a Cat’s Viewpoint? (On Russian Translations of Wisława Szymborska’s Poem Cat in an Empty Apartment)
This paper deals with some difficulties related to Russian translations of Wisława Szymborska’s poem Cat in an empty apartment. The question of presence and visibility of lyrical subject in the original text and its translations is one of the major issues presented in the article. An analysis of N. Astafiewa’s and N. Gorbaniewska’s tranlations has been conducted with special respect to the agentivity phenomenon on the level of verb forms. Linguistic categorization has also been mentioned. The author tries to present how differently Russian translators, who perform their typical role of poetry translators, strive for faithfulness of form and content of the original text and in what manner their solutions can influence the lyrical subject’s viewpoint.
Contribuições de uma teoria da consciência irrefletida para uma filosofia da liberdade a partir de A transcendência do Ego
Authors: Guimarães Deborah Moreira 
Published: June 2019

O propósito desse artigo é explicitar os aspectos fundamentais acerca da teoria da consciência desenvolvida por Sartre em A transcendência do Egono âmbito da passagem de seu projeto fenomenológico ao seu projeto ético. Partiremos da dicotomia entre “consciência e mundo” a fim de alcançarmos a distinção da consciência em níveis, o que será de extrema importância para se compreender o propósito ético que também envolve a interpretação da constituição egoica humana em sua relação com a condição de ser-no-mundo.
Survival rates of resin composite restorations in loadbearing situations in posterior teeth
Authors: Burke F J Trevor , Mackenzie Louis , Shortall Adrian CC 
Published: June 2019

The use of resin composite for routine restoration of cavities in posterior teeth is now commonplace, and will increase further following the Minamata Agreement and patient requests for tooth-coloured restorations in their posterior teeth. It is therefore relevant to evaluate the published survival rates of such restorations. A Medline search identified 144 possible studies, this being reduced to 24 when inclusion criteria were introduced. Of these, ten directly compared amalgam and composite, eight were cohort studies, and six were systematic reviews. It was concluded that posterior composites may provide restorations of satisfactory longevity and with survival rates generally similar to those published on amalgam restorations. However, the ability of the operator in placing the restoration may have a profound effect. CPD/Clinical Relevance: With the increasing use of composite for restorations in posterior teeth, it is relevant to note that these may provide good rates for survival.
Infinitely Many Solutions for a Non-homogeneous Differential Inclusion with Lack of Compactness
Authors: Ge Bin , Rădulescu Vicenţiu D. 
Published: June 2019

Abstract
In this paper, we consider the following class of differential inclusion problems in

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-\Delta_{p(x)}u+V(x)\lvert u\rvert^{p(x)-2}u\in a(x)\partial F(x,u)\quad\text{% in}\ \mathbb{R}^{N}.

We are concerned with a multiplicity property, and our arguments combine the variational principle for locally Lipschitz functions with the properties of the generalized Lebesgue–Sobolev space. Applying the nonsmooth symmetric mountain pass lemma and the fountain theorem, we establish conditions such that the associated energy functional possesses infinitely many critical points, and then we obtain infinitely many solutions.
Fabrication of 3D microstructures using grayscale lithography
Authors: Lima Frederico , Khazi Isman , Mescheder Ulrich , Tungal Alok C. , Muthiah Uma 
Published: June 2019

Abstract
Following the demand for three-dimensional (3D) micromachined structures, additive and subtractive processes were developed for fabrication of real 3D shapes in metals, alloys and monocrystalline Si (c-Si). As a primary structuring step for well-defined 3D structuring of the photoresist, grayscale lithography by laser direct writing was used. For additive fabrication of 3D microstructures, structured photoresist was used as molds. They were sputtered and subsequently electroplated by a metal (Cu) and an alloy (NiCo). The derived electroplated structures were demolded from the photoresist using an organic stripper. These metal structures are satisfactory replicas of the photoresist pattern. For subtractive pattern transfer of 3D structures into c-Si, reactive ion etching (RIE) was used to transfer the 3D photoresist structure into c-Si with 1:1 pattern transferability. The process parameters of RIE were optimized to obtain a selectivity of 1 and an anisotropy factor close to 1. Whereas conventional X-ray lithography (LIGA) and nanoimprint lithography result in 2.5D patterns, these techniques allow the fabrication of almost any arbitrary 3D shapes with high accuracy. In many cases, 3D structures (‘free forms’) are required, e.g. for molding of optical components such as spheres (or aspheres), channels for lab-on-a-chip and pillars for biological applications. Moreover, 3D structures on Si could be used as optical gratings and sensors.
Analysis of the Yielding Behavior of Electrorheological Suspensions by Controlled Shear Stress Experiments
Authors: Pavlínek Vladimír , Sáha Petr , Pérez-González José , de Vargas Lourdes , Stejskal Jaroslav , Quadrat Otakar 
Published: June 2019

AbstractThe yielding behavior of two model electrorheological suspensions of uncoated silica particles and silica coated with polyaniline base in silicone oil using controlled shear rate and controlled shear stress experiments has been analyzed. The results demonstrate that unlike the uncertain dynamic yield stress values estimated from the results obtained in the former mode by extrapolation of the unsteady shear stresses to zero shear rate, the controlled shear stress measurement permits to detect sensitively the region starting from the initial rupture of particle chain structure in the electric field at rest corresponding to a static yield stress τyand ending in total breakage of suspension structure at a breaking stress τb.. The latter quantity can be detected with a good accuracy and proved to be a reliable criterion of the stiffness of ER structure.
Rheology of LCP/PET Blends at Solid and Molten States of LCP
Authors: Hashmi S.A.R. , Kitano Takeshi 
Published: June 2019

Abstract
Liquid crystalline polymer (LCP) and polyethylene terephthalate (PET) were blended in an elastic melt extruder to make samples having different volume fractions of constituent polymers. Shear stress, shear viscosity, first normal stress difference at different shear rates under steady state conditions of these blends were evaluated at two different temperatures 265 and 285˚C. The LCP was in solid state at 265˚C and in melt state at 285˚C and was dispersed in molten matrix of PET at both temperatures. Shear viscosity of blend increased with addition of LCP in PET matrix. A maxima was observed in viscosity versus composition plot. Blends containing more than 50 vol. % of LCP in the blend show higher viscosity as compared to the constituent polymers. First normal stress difference, N1, increased with LCP content in the blend at 285˚C when ploted against shear stress whereas at 265˚C this trend was opposite. The increased value of N1 with shear rate was explained assuming a tendency of asymmetric particles to rotate under velocity gradient of suspending medium. At 285˚C N1 varied with shear stress in two stages. First stage was characterized with high sensitivity of N1 with shear stress, which reduced in second stage on plastic deformation of LCP droplets.
Ca2+-Induced Cold-Set Gelation of Whey Protein Isolate Fibrils
Authors: Bolder Suzanne G. , Hendrickx Hanneke , Sagis Leonard M.C. , van der Linden Erik 
Published: June 2019

Abstract
In this paper we describe the rheological behaviour of Ca2+-induced cold-set gels of whey protein mixtures. Cold- set gels are important applications for products with a low thermal stability. In previous work [1], we determined the state diagram for whey protein mixtures that were heated for 10 h at pH 2 at 80°C. Under these conditions, the major whey protein, β-lactoglobulin (β-lg), forms fibrils. When whey protein mixtures are heated at protein concentrations in the liquid solution regime of the state diagram, cold-set gels can be formed by adding Ca2+ ions at pH 7. We studied the rheological behaviour of cold-set gels for various sample compositions for whey protein mixtures. When keeping the total whey protein concentration constant, the elastic modulus, G’, for the cold-set gels decreased for increasing a-lactalbumin and bovine serum albumin ratios, because less material (β- lg fibrils) was available to form a gel network. In the cold-set gels the interactions between the β-lg fibrils induced by the calcium ions are dominant. The β-lg fibrils are forming the cold-set gel network and therefore determine the gel strength. a-Lactalbumin and bovine serum albumin are not incorporated in the stress-bearing structure of the gels.
Scattering from Shear-Ordered Dispersions
Authors: Versmold H. 
Published: June 2019

Abstract
Rheology is commonly used as a tool for analytics and quality control in latex technology. As soon as flow becomes essential for the structure measured in a scattering experiment we call it scattering from shear-ordered dispersions or rheologic scattering. In this paper it is shown that the structure of concentrated dispersions can with advantage be studied by scattering experiments. Theoretical and experimental aspects as well as examples of small-angle synchrotron x-ray and neutron scattering from colloidal dispersions, presented in the paper, are closely related to rheology.