bluuebunny/crossref_metadata_2025_split huggingface dataset:
GEL FILTRATION OF COW MILK WHEY PROTEINS
Authors: Yukalo V. , Datsyshyn K. 
Published: January 2019

The work considers the isolation of homogeneous precursor proteins of biologically active peptides from milk whey by gel filtration, in conditions that maximally ensure the preservation of their structure, composition, and properties. Considering the range of molecular masses of the main precursor proteins, the sephadex G-100 was selected for the gel filtration. As a result of the gel filtration of milk whey on a column with this sephadex, three peaks have been obtained, one of which was asymmetric and divided into two sectors. In total, four sectors from the three peaks have been received. Further, an electrophoretic analysis in the polyacrylamide gel of the proteins composition of all sectors was carried out. Sector A (the first peak) included immunoglobulins, lactoferrin, serum albumin. Sectors B and C (the second peak) consisted of β-lactoglobulin and α-lactalbumin in different ratios. The components of sector D (the third peak) had a small molecular weight and did not contain proteins. The next stage of the work was obtaining homogeneous lactoproteins. To this end, another gel filtration of the combined fractions of sectors A, B, and C was performed. Each of the chromatographic peaks obtained was divided into three ranges for the analysis of the proteins composition. Analytical electrophoresis of the combined chromatographic fractions of each range has shown that in six ranges out of nine, homogeneous precursor proteins of bioactive peptides were present. As a result of this repeated gel filtration on sephadex G-100, two homogeneous fractions (β-lactoglobulin, immunoglobulins) were obtained, which together, based on the results of the three gel filtrations, composed 59% of the whole milk whey protein. The processing of electrophoregrams, with the use of the image reading function imread, has shown high homogeneity of the fractions obtained (immunoglobulins ˃ 90%, and β-lactoglobulin ˃94%). These fractions were used to develop a biotechnology for obtaining and studying bioactive antihypertensive and bactericidal peptides from milk whey proteins.
SECONDARY PLANT RESOURCES AS PROSPECTIVE UNCONVENTIONAL SOURCES OF PECTIС SUBSTANCES
Authors: Aider M. , Olkhovatov E. , Pylypenko L. , Nikitchina T. , Kasyanov G. 
Published: January 2019

The secondary raw materials have been studied as sources of pectic substances necessary for the endo-ecological protection of the organism in the globally deteriorating living conditions of modern humans. The article reveals the significance and long-term benefits of such sources of pectic substances as fruit and seed coats, which are obtained in considerable quantities as a secondary raw material during the implementation of the technological process, and often do not find rational use. Research has been carried out on new prospective sources of pectin substances – secondary resources of processing soybean Glycine max (L.) Merrill, sainfoin Onobrýchis arenária, rapeseed Brassica napus L. oleifera, Sarepta mustard Brassica juncea (L.) Czern, and black mustard Brassica nigra (L.) W.D.J. Koch, castor bean Ricinus communis L., sunflower Helianthus annuus L. Fruit and seed coats of these plant species have been studied. The prospects of their secondary resources for pectin production have been shown. The assessment of the quantitative and qualitative characteristics of the pectic substances of the objects under study, as well as their fractional composition and analytical indicators, make it possible to characterize the potential functional, technological and therapeutic properties of pectin preparations. It has been indicated that in the polyuronid component (fraction of galacturonic acid), all the studied samples of surface tissues of soybean, mustard, sainfoin, sunflower, one rape variety meet international requirements for food pectin (52.87–73.22%), and one of them, the pectin from seed coat of the Valenta variety, meets the requirements for pectins for medical purposes (75.83%). Pectic substances of soybean, mustard, castor bean varieties are characterized by a high degree of esterification (62.37–76.88%) in contrast to the varieties of sainfoin and sunflower (45.29–55.15%). According to the degree of esterification, rape varieties are close to low-esterified pectiс substances – 59.34–61.48%. The prospects of using seed and fruit membranes as an unconventional secondary plant raw material to improve the environmental performance of production and to obtain a valuable therapeutic-and-prophylactic food ingredient have been substantiated.
MICROSTRUCTURAL ANALYSIS OF FORCEMEATS OF READY-TO-COOK CHOPPED MEAT WITH FUNCTIONAL INGREDIENTS
Authors: Paska M. , Bal-Prylypko L. , Masliichuk O. , Lychuk M. 
Published: January 2019

Meat products, at different technological stages and as finished articles, retain their morphological features. Microstructure analysis of the raw material, ready-to-cook products, or finished articles allows determining the presence of certain types of tissues, organs, spices – and low-value admixtures the recipe does not provide for, as well as reused raw materials. Microstructural studies of ready-to-cook chopped meat products allows identifying their components, establishing different properties of various tissue and cellular structures, and controlling the articles manufactured. Minced beef as the object of research was modified, with 5 %, 10 %, 15 % of the meat part replaced with lupin flour and 0.5% of elecampane root powder added as aromatic raw material. For microscopic examination, samples of the forcemeats developed were put marks on and fixed in a 10 % neutral formalin solution. The sections, as thick as 0.5–1 cm, were cut on a sledge microtome. They were stained with haematoxylin and eosin, and the PAS reaction. Light microscopy and microphotography of the tissue specimens were performed with a microscope Leica DM 2500 and a camera Leica DFC 450C with the software Leica aplitation suite 4.4. The micrographic investigation of the forcemeats revealed polygonal and round muscle fibres (their dark nuclei were clearly seen under the sarcolemma), concentrations of adipose tissue histologically characterized by a reticulate structure. In the microphotographs, lupin flour looks like groups of round light purple cytoplasm with dark purple nuclei in the centre of polygonal cells; bread looks like loose brown fibres; wavy violet fibres represent onions; and single dark brown spots marked elecampane. It has been shown that histological studies, with the PAS reaction used, are helpful in determining the meat and plant content in the ready-to-cook meat developed, and that haematoxylin and eosin can help determine the functional ingredients content.
Refining the Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma
Authors: Margalit Ofer , Mamtani Ronac , Kopetz Scott , Yang Yu-Xiao , Lawrence Yaacov R. , Abu-Gazala Samir , Reiss Kim A. , Golan Talia , Halpern Naama , Aderka Dan , Giantonio Bruce , Shacham-Shmueli Einat , Boursi Ben 
Published: January 2019

Abstract

Background
Current guidelines include the use of adjuvant oxaliplatin in clinical stage II or III rectal adenocarcinoma. However, its efficacy is supported by a single phase II trial. We aimed to examine whether oxaliplatin confers survival benefit in this patient population.

Methods
Using the National Cancer Database (2006–2013) we identified 6,868 individuals with clinical stage II or III rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy. We used multivariate Cox regression to evaluate survival differences according to treatment intensity and change from clinical to pathological stage.

Results
We demonstrated an association with improved overall survival with the use of doublet adjuvant chemotherapy in pathological stage III rectal adenocarcinoma (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.67–0.92). This association was confirmed in patients with clinical stage III and subsequent pathological stage III disease (HR, 0.69; 95% CI, 0.57–0.83) and was not observed in patients who progressed from clinical stage II to pathological stage III disease. Doublet adjuvant chemotherapy was not associated with improved overall survival in patients with pathological stage 0 or I disease, regardless of their clinical stage.

Conclusion
Adjuvant oxaliplatin following neoadjuvant chemoradiotherapy in rectal adenocarcinoma was confirmed in patients with clinical stage III and subsequent pathological stage III disease. Omission of oxaliplatin can be considered in pathological complete response or pathological stage I disease.
Bridge: Person-Centered Collaborative Care for Patients with Serious Mental Illness and Cancer
Authors: Irwin Kelly E. , Park Elyse R. , Fields Lauren E. , Corveleyn Amy E. , Greer Joseph A. , Perez Giselle K. , Callaway Catherine A. , Jacobs Jamie M. , Nierenberg Andrew A. , Temel Jennifer S. , Ryan David P. , Pirl William F. 
Published: January 2019

Abstract

Background
Individuals with serious mental illness (SMI) experience increased cancer mortality due to inequities in cancer treatment. Psychiatric care at cancer diagnosis may improve care delivery, yet models for integrating psychiatry and cancer care are lacking. We assessed the feasibility and acceptability of a person-centered collaborative care trial for SMI and cancer.

Subjects, Materials, and Methods
We developed the Bridge intervention for patients with SMI (schizophrenia, bipolar disorder, and severe major depression) and cancer. Bridge includes proactive identification of SMI, person-centered care from a psychiatrist and case manager, and collaboration with oncology. We conducted a 12-week, single-group trial in patients with SMI and a new breast, gastrointestinal, lung, or head/neck cancer. We assessed the feasibility of patient identification, enrollment and study completion; evaluated acceptability and perceived benefit with exit interviews with patients, caregivers, and oncology clinicians; and examined change in psychiatric symptoms with the Brief Psychiatric Rating Scale (BPRS).

Results
From November 2015 to April 2016, 30/33 eligible patients (90.9%) enrolled, and 25/29 (86.2%) completed assessments at all timepoints, meeting feasibility criteria. Of 24 patients, 23 (95.8%) found meeting with the psychiatrist helpful; 16/19 caregivers (84.2%) shared that Bridge addressed key caregiving challenges. Oncology clinicians evaluated Bridge as “very” or “most” useful for 94.3% of patients. Exit interviews with all participant groups suggested that Bridge fostered patient-clinician trust, increased access to psychiatric treatment, and enabled patients to initiate and complete cancer treatment. Psychiatric symptoms on the BPRS improved from baseline to 12 weeks.

Conclusion
Bridge is a feasible and acceptable care delivery model for patients with SMI, their caregivers, and oncology clinicians. Randomized trials are warranted to assess the efficacy of improving cancer outcomes in this underserved population.
A Generic Circuit Model for Memristor Based One Diode-One Resistor Devices
Authors: GÜL Fatih 
Published: January 2019

Memristor-based resistive random access
memory (RRAM) devices are very good competitors for next generation
non-volatile crossbar memory applications.
The sneak paths problem is one of the main constraints in fabricating
crossbar memory devices. The one diode-one resistor (1D1R) structure design is
effective for suppressing the sneak paths problem. Suitable circuit models are
needed to simulate semiconductor structures.

A general circuit model for memristor-based
one diode-one resistor structures is proposed in this work. The Simulation
Program with Integrated Circuit Emphasis (SPICE) environment was used to
simulate the designed circuit. Well-known mathematical models such as those of
Strukov, Biolek, Joglekar, Prodromakis and Zha were used to simulate the
memristor component of the circuit. The current-voltage characteristics were
obtained for different mathematical models. All results were compatible with
the expected characteristics. The best
fit characteristics were acquired using the Zha and Strukov models.
Penile strangulation by a metal ring: an easy and unique thread method for removal of the ring
Authors: Vyas Kunj N. , Solanki Mehul I. 
Published: January 2019

Penile incarceration is a rare but serious problem. Rapid treatment is necessary to prevent penile infarction. Glass bottles, metal rings, steel nuts and bull rings have been reported as constricting agents. Depending on the type of material, various tools such as diamond drills, bolt cutters and glass saws have been used to remove the objects. Penile strangulation by metal ring is a rare surgical emergency situation which requires urgent intervention to avoid vascular and urethral injury. It is usually associated with an attempt to improve sexual act and/or to prolong erection, psychosexual disorder. It is difficult to cut a metal ring as the edema was out of proportion and metal ring had made pressure ulcer at pen scrotal junction. The treatment of penile strangulation is decompression of the constricted penis to facilitate free blood flow and micturition. It requires no particular skill but does require resourcefulness to perform the removal simply and effectively, and with as little discomfort for the patient as possible. Here, author presented a case of penile strangulation in which metal ring was removed by silk thread.
Massive left lobe liver cyst: a rare case report and review of literature
Authors: Muthammal Ramula , Natarajan Arivazagan , Raj Mohan , Radhakrishnan Ramprasath 
Published: January 2019

Huge Cyst of the liver not frequently found. This case of massive liver cyst (left lobe) in a female patient is reported for its rarity. In this case, the patient presented with no other complaints except distention of abdomen and vague pain abdomen. To highlight diagnostic challenges and treatment options available to rural population, that is affordable and accessible. A 57 years old female patient from nearby village, presented with distention of abdomen for 5years, which was small to start with and gradually increasing in size to attain the present size. Preoperatively, it was a huge tensely cystic swelling arising from left lobe of liver occupying whole upper abdomen. Swelling appeared to be arising from segment II and III (Couinaud system), right lobe compressed to a rim. The cyst was opened anteriorly and drained 4.8l of clear fluid. Marsupialization of the cyst was done. Though huge cystic swellings are comparatively rare, they should be considered in the pre-operative differential diagnosis of abdominal masses. They can be easily diagnosed and managed in hospitals with limited resources and are affordable to the patients also.
Conhecimento científico e tecnológico dos povos africanos: estratégia de resistência à tradição seletiva no ensino de ciências
Authors: Brito Marlene Oliveira de , Machado Vitor 
Published: January 2019

<p>O presente artigo examina possibilidades de inclusão da história e culturas africanas e afro-brasileiras no ensino de ciências, em atendimento à Lei 10.639/03, defendendo a inserção da diversidade étnico-racial e cultural a partir do recorte histórico referente ao conhecimento científico de povos africanos. A análise é realizada nos conteúdos propostos no currículo escolar oficial da Secretaria de Educação do Estado de São Paulo (SEE/SP), especificamente para o 7º ano do ensino fundamental. A proposta é refletir sobre a atuação pedagógica dos envolvidos na educação escolar, como instrumento capaz de resultar em significações no posicionamento diante as demandas relativas ao enfrentamento do preconceito e da discriminação com fundamento racial.</p><p><strong>Palavras-chave</strong></p><p>Educação antirracista. Ciência e tecnologia africana. Currículo e ensino de ciências.</p><p> </p><p><strong>Scientific and Technological Knowledge of African Peoples: Strategy of Resistance to the Selective Tradition in Science Education</strong></p><p><strong>Abstract</strong></p><p>This article examines possibilities of including African and AfroBrazilian history and culture in science education, in compliance with the Law 10.639 / 03. It advocates the inclusion of ethnic-racial and cultural diversity, based on historical references to the scientific knowledge of African peoples. We analyze the contents proposed in the official curriculum issued by the Education Department of the State of São Paulo (SEE / SP), specifically for the 7th grade of primary education. We propose a reflection on the pedagogical action of those involved in school education as an instrument that can produce significations in stances towards demands related to fighting racially based prejudice and discrimination.</p><p><strong>Keywords</strong></p><p>Anti-racist education. African science and technology. Curriculum. Science teaching.</p>
A carreira do professor da rede pública de Chicago
Authors: Becker Howard S. 
Published: January 2019

<p>As carreiras dos professores de Chicago exibem movimentações “horizontais” entre cargos em um mesmo nível da hierarquia escolar, em termos de configuração dos problemas profissionais básicos apresentados por cada cargo, mais do que movimentações verticais entre vários desses níveis. Um grande padrão de carreira consiste em mudar-se da escola de classe baixa, onde as carreiras geralmente começam; outro padrão consiste em adaptarse, ao longo de um período de anos, aos problemas de tais escolas. Uma vez estabelecido em uma escola, o professor pode ser perturbado por mudanças relacionadas à estrutura da vizinhança ou ao pessoal administrativo com quem ele lida.</p><p><strong>Palavras-chave</strong></p><p>Carreira docente. Movimentação docente. Desigualdades socioespaciais. Relações étnico-raciais.</p><p> </p><p><strong>The career of the Chicago public schoolteacher</strong></p><p><strong>Abstract</strong></p><p>The careers of Chicago teachers exhibit “horizontal” movement among positions at one level of the school-work hierarchy in terms of the configuration of the occupation’s basic problems presented by each rather than vertical movement between several such levels. One major career pattern consists in moving from the lower-class school in which careers usually begin; another consists in adjusting, over a period of years, to the problems of such schools. Having settled in a school, the teacher may be upset by changes in neighborhood structure or in the administrative personnel with whom she deals.</p><p><strong>Keywords</strong></p><p>Teaching career. Teacher movement. Socio-spatial inequalities. Ethnic-racial relations.</p>
Nenhum movimento curricular no Brasil teve força para mudar a prática dos professores em matemática.
Authors: Amabile Mansutti Maria 
Published: January 2019

<p>Maria Amabile Mansutti sempre se interessou pela matemática na escola, desde as séries iniciais. Ela não gosta muito de falar sobre isso. Mas fatos são fatos e uma informação como essa não poderia deixar de ser dada na abertura de uma entrevista com uma professora que dedicou toda a sua vida profissional a discutir como se ensina e se aprende essa disciplina. Mesmo sem ter licenciatura na área (ela é formada em Pedagogia pela Universidade de São Paulo), conversa com os especialistas sobre números, operações, geometria, estatística e ainda acrescenta conhecimentos sobre como as crianças aprendem esses conteúdos e a melhor maneira de ensinálos – dois temas, aliás, em que nenhum bacharel e poucos licenciados se arriscam.</p><p>Atual diretora de Tecnologias Educacionais do Centro de Estudos e Pesquisas em Educação, Cultura e Ação Comunitária (Cenpec), Amabile tem especialização em Didática da Matemática pela Pontifícia Universidade Católica de São Paulo (PUC-SP). Fez carreira na rede municipal da capital paulista como professora, técnica em educação e gestora. Como formadora de professores, atuou em diversas redes municipais e estaduais e em escolas particulares. Integrou a equipe que elaborou os PCN de matemática para o Ensino Fundamental e implantou o Programa Parâmetros em Ação em mais de 3 mil municípios. Foi diretora do Departamento de Política da Educação Fundamental da Secretaria da Educação Fundamental do Ministério da Educação (MEC). De 2006 a 2011 foi consultora de programas voltados à Educação de Jovens e Adultos (EJA), desenvolvidos pela Organização Alfasol junto ao Ministério de Educação de São Tomé e Príncipe.</p>
Profil Pengelolaan dan Ketersediaan Obat Anti Diabetes Oral di Puskesmas
Authors: Rahem Abdul 
Published: January 2019

Pendahuluan: Ketersediaan obat di puskesmas merupakan aspek yang sangat penting dalam menjamin kerasionalan penggunaan obat oleh pasien, dan membangun kepercayaan masyarakat terhadap fasilitas pelayanan kesehatan tersebut. Pengelolaan obat di puskesmas haruslah baik dan benar, karena pengelolaan yang baik dan benar akan menjamin ketersediaan obat sesuai dengan kebutuhan puskesmas. Tujuan: Untuk mengetahui profil pengelolaan dan ketersediaan obat antidiabetes oral pada Puskesmas di Kabupaten Pamekasan. Metode: Desain penelitian deskriptif observasional, metode pengumpulan data dilakukan dengan menggunakan kuesioner sebagai instrumen. Penelitian ini dilakukan pada 11 puskesmas di Kabupaten Pamekasan. Hasil: Semua puskesmas melakukan perencanaan pada awal tahun dengan menggunakan pola konsumsi sebagai pertimbangan menentukan jenis dan jumlah kebutuhan obatnya. Pengadaan kepada Dinas Kesehatan dilakukan pada saat obat akan habis atau sesuai kebutuhan. Penyimpanan obat di puskesmas 72,72 % tidak sesuai dengan standar yang berlaku, ketersediaan obat antidiabetes oral dengan kategori aman hanya 23,3%. Kesimpulan: Pengelolaan obat pada 11 puskesmas di Kabupaten Pamekasan belum sesuai dengan standar, dan ketersediaan obat dengan kategori aman hanya 23,3%.
Pengetahuan Siswa Lulusan SMA Terhadap Tugas Apoteker di Berbagai Bidang Kerja Kefarmasian
Authors: Ratri Dinda Monika Nusantara , Puspitasari Arina Dery 
Published: January 2019

Pendahuluan: Apoteker adalah profesi kesehatan yang kompeten terkait pengelolaan obat-obatan. Banyak upaya yang dilakukan oleh organisasi profesi agar peranan Apoteker dalam melakukan pekerjaan kefarmasian lebih dirasakan kehadirannya. Siswa lulusan SMA merupakan calon mahasiswa yang akan meneruskan jenjang pendidikan ke tingkat lebih lanjut, sehingga pengetahuan calon mahasiswa terkait sebuah profesi penting diamati untuk mengetahui strategi promosi pendidikan farmasi yang dapat dilakukan. Tujuan: Studi ini bertujuan untuk mengamati pengetahuan siswa lulusan SMA terhadap tugas Apoteker diberbagai lingkungan kerja kefarmasian Metode: Studi ini merupakan studi cross sectional dengan metode pengambilan accidental sampling. Total 128 siswa lulusan SMA diberikan kuesioner yang berisi pertanyaan terkait tugas Apoteker diberbagai bidang kerja kefarmasian, selanjutnya hasil kuesioner tersebut dilakukan penilaian terkait tingkat pengetahuan. Hasil: Dari studi ini didapatkan persentase siswa yang memiliki pengetahuan baik terkait perihal yang dipelajari dalam pendidikan farmasi hanya 37 (28,91%.) responden. Pengetahuan baik tentang pekerjaan kefarmasian yang dilakukan seorang Apoteker paling tinggi adalah dilingkungan kerja pengawasan obat dan makanan yakni sebesar 87 (67,97%) responden, selanjutnya Apotek 85 (66,41%) responden, Rumah Sakit 77 (60,16%) responden dan Industri 68 (53,12%) responden. Kesimpulan: Skor pengetahuan siswa lulusan SMA terkait tugas Apoteker tertinggi adalah di area pengawasan obat dan makanan, sedangkan paling rendah di area industri.