bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability and Stabilization of Fractional‐Order Systems with Different Derivative Orders: An LMI Approach
Authors: Badri Pouya , Sojoodi Mahdi 
Published: July 2018

AbstractStability and stabilization analysis of fractional‐order linear time‐invariant (FO‐LTI) systems with different derivative orders is studied in this paper. First, by using an appropriate linear matrix function, a single‐order equivalent system for the given different‐order system is introduced by which a new stability condition is obtained that is easier to check in practice than the conditions known up to now. Then the stabilization problem of fractional‐order linear systems with different fractional orders via a dynamic output feedback controller with a predetermined order is investigated, utilizing the proposed stability criterion. The proposed stability and stabilization theorems are applicable to FO‐LTI systems with different fractional orders in one or both of 0 < α < 1 and 1 ≤ α < 2 intervals. Finally, some numerical examples are presented to confirm the obtained analytical results.
Development of a new anti‐CD123 monoclonal antibody to target the human CD123 antigen as an acute myeloid leukemia cancer stem cell biomarker
Authors: Abdollahpour‐Alitappeh Meghdad , Razavi‐Vakhshourpour Sepand , Abolhassani Mohsen 
Published: July 2018

AbstractAcute myeloid leukemia (AML) is a clonal hematologic malignancy arising from a small population of leukemic cells initiating the disease. CD123 is differentially expressed in AML blasts compared with normal hematopoietic stem and progenitor cells. The aim of this study was to develop specific monoclonal antibodies (mAbs) directed against AML. Three BALB/c mice were immunized with the human CD123 antigen, and the immune spleen cells were fused with the SP2/0 myeloma cell line. Hybridomas were screened by indirect enzyme‐linked immunosorbent assay (ELISA), and the positive hybrids were cloned by limiting dilution. The mAb isotype was determined, ascitic fluids were produced, and antibodies were purified using Fast protein liquid chromatography (Sephacryl S‐200). The specificity of the hybridomas was examined by ELISA, cell‐based ELISA, and flow cytometry. After three rounds of cell cloning, four anti‐CD123 secreting hybridomas were obtained with the IgM isotype. Among them, one stable hybrid, designated sC1, exhibited the higher ability to recognize the CD123 antigen, as compared with the other hybridomas. Our results showed that sC1 has the ability to bind specifically to the CD123 antigen (41.36%) on the cell surface. The anti‐CD123 mAb produced in this study may be useful for the development of both diagnostic and therapeutic purposes for AML.
Isolation and characterization of a novel nicotinophilic bacterium, Arthrobacter sp. aRF‐1 and its metabolic pathway
Authors: Ruan Aidong , Gao Yuan , Fang Chao , Xu Yaofei 
Published: July 2018

AbstractNicotine is a potent parasympathomimetic stimulant and an important natural alkaloid mainly found in the Nicotiana genus of plants. It can directly threaten ecological security and human health in tobacco waste, wastewater, and other forms of tobacco production. Therefore, it is the basis of nicotine pollution prevention and of great application value to explore efficient and a wide range of nicotinophilic bacteria for tobacco industry and environmental protection. In this study, one nicotinophilic bacterium was isolated from the soil, which accumulated tobacco waste over 50 years at a Hefei cigarette factory. The strain was named aRF‐1, which was identified as Arthrobacter sp. by analysis. The nicotine degradation tests showed that the optimum temperature for cell growth and metabolism of nicotine of Arthrobacter sp. aRF‐1 was 30 °C, and the optimum initial pH value was about 7.0. Under the optimum experimented conditions, it can tolerance nicotine concentration as high as 8 g·L−1. The highest removal rate of nicotine was 93.8% in 72 H in nonsterilization contaminated soil by Arthrobacter sp. aRF‐1. LC‐MS/MS was used to analyze the nicotine metabolic intermediates of strain Arthrobacter sp. aRF‐1. A total of nine major metabolites that were detected were able to metabolize nicotine along a variant pathway of pyridine and pyrrolidine, and there may be more than two nicotine metabolic pathways for Arthrobacter sp. aRF‐1 through the analysis of the main intermediate products.
Meta-analysis of the diagnostic accuracy of ultrasound-guided fine-needle aspiration and core needle biopsy in diagnosing axillary lymph node metastasis
Authors: Balasubramanian I , Fleming C A , Corrigan M A , Redmond H P , Kerin M J , Lowery A J 
Published: July 2018

Abstract

Background
Axillary lymph node status remains a significant prognostic indicator in breast cancer. Here, the diagnostic accuracy of ultrasound-guided fine-needle aspiration (US-FNA) and ultrasound-guided core needle biopsy (US-CNB) in axillary staging was compared.

Methods
A comprehensive search was undertaken of all published studies comparing the diagnostic accuracy of US-CNB and US-FNA of axillary lymph nodes in breast cancer. Studies were included if raw data were available on the diagnostic performance of both US-FNA and US-CNB, and compared with final histology results. Relevant data were extracted from each study for systematic review. Meta-analysis was performed using a random-effects model. The pooled sensitivity and specificity of US-FNA and US-CNB were obtained using a bivariable model. Summary receiver operating characteristic (ROC) graphs were created to confirm diagnostic accuracy.

Results
Data on a total of 1353 patients from six studies met the inclusion criteria and were included in the final analysis. US-CNB was superior to US-FNA in diagnosing axillary nodal metastases: sensitivity 88 (95 per cent c.i. 84 to 91) versus 74 (70 to 78) per cent respectively. Both US-CNB and US-FNA had a high specificity of 100 per cent. Reported complication rates were significantly higher for US-CNB compared with US-FNA (7·1 versus 1·3 per cent; P &lt; 0·001). Conversely, the requirement for repeat diagnostic procedures was significantly greater for US-FNA (4·0 versus 0·5 per cent; P &lt; 0·001).

Conclusion
US-CNB is a superior diagnostic technique to US-FNA for axillary staging in breast cancer.
Complementarity patterns in cognitive therapy for major depressive disorder
Authors: Thompson Katherine , Schwartzman Deborah , D'Iuso Debora , Dobson Keith S. , Drapeau Martin 
Published: July 2018

AbstractBackgroundInterpersonal theories suggest that cohesion between two individuals can be described by the degree to which they communicate harmoniously or, the complementarity, of their interactions (Gurtman, 2001; Kiesler, 1996). Friendly complementarity within therapy dyads is linked to both alliance and treatment outcome (Kiesler & Watkins, 1989; von der Lippe, Monsen, Rønnestad & Eilertsen, 2008; Samstag et al., 2008; Tracey, Sherry & Albright, 1999).AimThe purpose of this study was to identify complementarity patterns that may help or hinder the effectiveness of cognitive therapy (CT) for depression.MethodThe Structural Analysis of Social Behavior (Benjamin, 1974) was used to code CT sessions for individuals with depression. Dyads (N = 16) were divided into high‐ and low‐change groups. Lag Sequential Analysis (Sackett, 1979) was used to analyse first order sequences in client and therapist interpersonal behaviour.FindingsAs expected, complementarity was better among high‐change dyads for affiliative behaviour. Low‐change dyads demonstrated stronger patterns of complementarity along the autonomy axis.ConclusionThis preliminary investigation illustrates different communication patterns among high‐ and low‐change dyads. Implications for clinical practice are discussed.
Bcl6 knockdown aggravates hypoxia injury in cardiomyocytes via the P38 pathway
Authors: Gu Yang , Luo Man , Li Yong , Su Zhongping , Wang Yaqing , Chen Xiru , Zhang Siqi , Sun Wei , Kong Xiangqing 
Published: July 2018

AbstractB‐cell lymphoma 6 (Bcl6) functions as a sequence‐specific transcriptional repressor and negative regulator of many signaling proteins. The effects of Bcl6 on cardiomyocyte injury are not clear. This study was designed to determine whether Bcl6 affects hypoxia‐induced cardiomyocyte injury and, if so, to identify the underlying mechanism. To meet this aim, cardiomyocytes were exposed to hypoxia and Bcl6 siRNA was used to silence Bcl6 in cardiomyocytes. Bcl6 knockdown under physiological conditions caused increased oxidative stress, apoptosis, and expression of pro‐inflammatory cytokines. Increased inflammatory response, oxidative stress, and apoptosis were observed after cells were exposed to hypoxia for 24 h. Bcl6 knockdown aggravated cardiomyocyte injury when exposed to hypoxia. Bcl6 knockdown increased P38 activation without affecting JNK and ERK phosphorylation levels. Treatment with a P38 inhibitor reversed the Bcl6 silencing‐induced deteriorating phenotype, as evidenced by reduced inflammatory response, improved oxidative stress response, and increased cell viability. The results indicate that Bcl6 knockdown causes cardiomyocyte injury at baseline conditions and aggravates cardiomyocyte hypoxia injury via activating the P38 pathway.
An Organotin Vanadate with Sodalite Topology and Catalytic Versatility in Oxidative Transformations
Authors: Gomes Ana C. , Antunes Margarida M. , Abrantes Marta , Valente Anabela A. , Paz Filipe A. Almeida , Gonçalves Isabel S. , Pillinger Martyn 
Published: July 2018

AbstractThe new coordination polymer formulated as [Et3SnVO3] (1) has been synthesized and shown by a combined single‐crystal and synchrotron powder X‐ray diffraction structural analysis, supported by solid‐state NMR, to possess a three‐dimensional network structure with the sodalite topology, formed by tetravanadate polyanions, [V4O12]4−, that are linked by Et3Sn+spacers. The catalytic versatility of compound1for liquid phase organic reactions was demonstrated by applying it for the epoxidation of olefins, the oxidative dehydrogenation of alcohols, and the oxidation of benzyl alcohol to benzaldehyde and benzoic acid, usingtert‐butyl hydroperoxide (TBHP) as oxidant. Compound1acts a solid reservoir for soluble, catalytically active species, which promote high selectivities to the epoxide and carbonyl (aldehyde/ketone/acid) products. The epoxidation activity compares favorably with those reported for other organotin molybdate, tungstate and vanadate coordination polymers, and is superior to that displayed by the starting materials used for its synthesis (Et3SnBr and NH4VO3) and the metavanadate NBu4VO3.
Copper‐(II) Catalyzed N‐Formylation and N‐Acylation of Aromatic, Aliphatic, and Heterocyclic Amines and a Preventive Study in the C‐N Cross Coupling of Amines with Aryl Halides
Authors: Sonawane Rahul B. , Rasal Nishant K. , Bhange Dattatraya S. , Jagtap Sangeeta V. 
Published: July 2018

AbstractA Cu‐(II) catalyzed N‐formylation and N‐acylation of amines with moderate to excellent yields, using N, N‐dimethyl formamide (DMF) and N, N‐dimethyl acetamide (DMA) as a formyl and acylating sources in the presence of 1,2,4‐triazole is reported. This novel, highly efficient and simple protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines. In addition, the conditions to prevent N‐formylation and N‐acylation impurities in the C−N cross coupling of amines and aryl halides are described typically when DMF and DMA are used as solvents, with various catalysts, ligands, and bases.
Synthesis of Industrial Primary Diamines via Intermediate Diols – Combining Hydroformylation, Hydrogenation and Amination
Authors: Fuchs Sarah , Lichte Dominik , Jolmes Tristan , Rösler Thorsten , Meier Gregor , Strutz Heinz , Behr Arno , J.Vorholt Andreas 
Published: July 2018

AbstractA homogenous transition metal catalysis that combines hydroformylation, hydrogenation and direct amination presents an elegant multi‐step pathway for synthesising primary diamines from olefins and ammonia. The valuable intermediate TCD‐diamine is obtained, which has a wide range of industrial applications as a monomer building block. The rhodium‐catalysed hydrohydroxymethylation step converts non‐conjugated dienes to the intermediate diols. Ammonia is added in a second ruthenium‐catalysed amination step to obtain primary diamines. The conditions for both reactions were first optimised independently and combined to design a tandem reaction. For the amination reaction of the diol, excellent diamine yields of up to 88 % in toluene were achieved. An analysis of the interactions between the two catalytic systems demonstrated that the conditions of both single reaction steps counteract each other, meaning the presence of either rhodium or ruthenium blocks the other respective reaction. Using a two‐step approach, optimised reaction conditions were applied to achieve equally high diamine yields of 88 %.
Spectroscopy and Photodissociation of the Perfluorooctanoate Anion
Authors: Douix Suzie , Dossmann Héloïse , Nicol Edith , Duflot Denis , Giuliani Alexandre 
Published: July 2018

AbstractPerfluorocarbons, a class of fully fluorinated compounds, are highly persistent and toxic pollutants that are receiving increasing attention due to their widespread environmental distribution. In this study, attention was focused on one compound in particular, namely, perfluorooctanoic acid (PFOA). The first investigation of the UV/VUV photochemistry of the PFOA anion in the gas phase by action spectroscopy of selected ions is reported. Two main relaxation channels were identified: photodissociation and photodetachment. Absolute cross sections for the individual observed processes were measured. DFT calculations and natural transition orbital analysis were carried out to help in the interpretation of the experimental results.
In vitro phase I metabolism of three phenethylamines 25D‐NBOMe, 25E‐NBOMe and 25N‐NBOMe using microsomal and microbial models
Authors: Grafinger Katharina Elisabeth , Stahl Katja , Wilke Andreas , König Stefan , Weinmann Wolfgang 
Published: July 2018

AbstractNumerous 2,5‐dimethoxy‐N‐benzylphenethylamines (NBOMe), carrying a variety of lipophilic substituents at the 4‐position, are potent agonists at 5‐hydroxytryptamine (5HT2A) receptors and show hallucinogenic effects. The present study investigated the metabolism of 25D‐NBOMe, 25E‐NBOMe, and 25N‐NBOMe using the microsomal model of pooled human liver microsomes (pHLM) and the microbial model of the fungi Cunninghamella elegans (C. elegans). Identification of metabolites was performed using liquid chromatography–high resolution–tandem mass spectrometry (LC–HR–MS/MS) with a quadrupole time‐of‐flight (QqToF) instrument. In total, 36 25D‐NBOMe phase I metabolites, 26 25E‐NBOMe phase I metabolites and 24 25N‐NBOMe phase I metabolites were detected and identified in pHLM. Furthermore, 14 metabolites of 25D‐NBOMe, 11 25E‐NBOMe metabolites, and nine 25N‐NBOMe metabolites could be found in C. elegans. The main biotransformation steps observed were oxidative deamination, oxidative N‐dealkylation also in combination with hydroxylation, oxidative O‐demethylation possibly combined with hydroxylation, oxidation of secondary alcohols, mono‐ and dihydroxylation, oxidation of primary alcohols, and carboxylation of primary alcohols. Additionally, oxidative di‐O‐demethylation for 25E‐NBOMe and reduction of the aromatic nitro group and N‐acetylation of the primary aromatic amine for 25N‐NBOMe took place. The resulting 25N‐NBOMe metabolites were unique for NBOMe compounds. For all NBOMes investigated, the corresponding 2,5‐dimethoxyphenethylamine (2C‐X) metabolite was detected. This study reports for the first time 25X‐NBOMe N‐oxide metabolites and hydroxylamine metabolites, which were identified for 25D‐NBOMe and 25N‐NBOMe and all three investigated NBOMes, respectively. C. elegans was capable of generating all main biotransformation steps observed in pHLM and might therefore be an interesting model for further studies of new psychoactive substances (NPS) metabolism.
Polyvinyl Alcohol/Polypyrrole/Molecularly Imprinted Polymer Nanocomposite as Highly Selective Chemiresistor Sensor for 2,4‐DNT Vapor Recognition
Authors: Koudehi Masoumeh Foroutan , Pourmortazavi Seied Mahdi 
Published: July 2018

AbstractIn this research, a chemiresistor sensor coated with the polyvinyl alcohol/polypyrrole/molecularly imprinted polymer (PVA/PPy/MIP) nanocomposite was designed and fabricated to detect the vapor of 2,4‐DNT as a nitroaromatic explosive material. The molecularly imprinted polymer was composed of molecular nanoparticles containing cavities compatible with DNT; while, the nanoparticles were synthesized using PVA and glutaraldehyde as functionalized polymer and cross‐linking agent, respectively. Composition and chemical properties of the synthesized MIP and PPy nanoparticles were investigated using scanning electron microscopy (SEM), infrared Fourier transform spectroscopy (ATR‐FTIR), and X‐ray diffraction (XRD) analyses. Results indicated that the nanoparticles of polypyrrole and the synthesized MIP have an average particle sizes of 56 nm and 45 nm, respectively. Afterwards, sensor surface was coated by a thin layer of nanocomposite composed of PVA, the PPy and MIP nanoparticles. The prepared sensors were calibrated and performance‐tested in a static setup. The developed sensor was used to measure different concentrations (0.1–150 ppm) of the explosive vapor. The coated sensor presented a linear range of response within the concentration range of 0.1–70 ppm. Also, selectivity tests were carried out in the presence of DNT and vapor of other organic matters and the results indicated that the designed sensor possesses high sensitivity and selectivity toward DNT.
Voltammetric Sensor with Replaceable Polyaniline‐DNA Layer for Doxorubicin Determination
Authors: Kulikova T. N. , Porfireva A. V. , Shamagsumova R. V. , Evtugyn G. A. 
Published: July 2018

AbstractNew voltammetric DNA sensor has been developed on the base of glassy carbon electrode covered with electropolymerized polyaniline with entrapped native DNA saturated with Methylene blue. The thickness and redox properties of the coating are easily regulated by the number of potential cycles and pH of the solution. Doxorubicin competes with Methylene blue for DNA binding sites and suppresses the electron transfer within the layer. The measurement of the decay of the cathodic peak current made it possible to determine down to 0.01 nM doxorubicin. After that, DNA can be replaced by consecutive treatment of the biosensor with concentrated HCl and fresh DNA solution. Second involvement of DNA was confirmed by electrochemical impedance spectroscopy. The DNA sensor developed was tested on artificial samples mimicking ionic content of human serum and on commercial drug formulation containing doxorubicin.
Fuel Cell Electric Vehicle‐to‐Grid: Experimental Feasibility and Operational Performance as Balancing Power Plant
Authors: Oldenbroek V. , Hamoen V. , Alva S. , Robledo C. B. , Verhoef L. A. , van Wijk A. J. M. 
Published: July 2018

AbstractThe world's future energy supply will include intermittent renewable sources, such as solar and wind power. To guarantee reliability of supply, fast‐reacting, dispatchable and renewable back‐up power plants are required. One promising alternative is parked and grid‐connected hydrogen‐powered fuel cell electric vehicles (FCEVs) in “Vehicle‐to‐Grid“ systems. We modified a commercial FCEV and installed an external 9.5 kW three‐phase alternating current (AC) grid connection. Our experimental verification of this set‐up shows that FCEVs can be used for mobility as well as generating power when parked. Our experimental results demonstrate that present‐day grid‐connected FCEVs can respond to high load gradients in the range of –760 % s−1 to + 730 % s−1, due to the parallel connection of the high voltage battery and the fuel cell stack. Virtual power plants composed of multiple grid‐connected FCEVs could perform higher power gradients than existing fast‐reacting thermal power plants with typical power gradients of 1.67 % s−1. Hydrogen consumption in 9.5 kW AC grid‐connected mode was 0.55 kg h−1, resulting in a Tank‐To‐Grid‐AC efficiency of 43% on a higher heating value basis (51 % on a lower heating value basis). Direct current to alternating current efficiency was 95 %.
Ambiguity preferences for health
Authors: Attema Arthur E. , Bleichrodt Han , L'Haridon Olivier 
Published: July 2018

AbstractIn most medical decisions, probabilities are ambiguous and not objectively known. Empirical evidence suggests that people's preferences are affected by ambiguity. Health economic analyses generally ignore ambiguity preferences and assume that they are the same as preferences under risk. We show how health preferences can be measured under ambiguity, and we compare them with health preferences under risk. We assume a general ambiguity model that includes many of the ambiguity models that have been proposed in the literature. For health gains, ambiguity preferences and risk preferences were indeed the same. For health losses, they differed with subjects being more pessimistic in decision under ambiguity. Utility and loss aversion were the same for risk and ambiguity. Our results imply that reducing the clinical ambiguity of health losses has more impact than reducing the ambiguity of health gains, that utilities elicited with known probabilities may not carry over to an ambiguous setting, and that ambiguity aversion may impact value of information analyses if losses are involved. These findings are highly relevant for medical decision making, because most medical interventions involve losses.
Virtualization of government‐to‐citizen engagement process: Enablers and constraints
Authors: Ofoeda Joshua , Boateng Richard , Asmah Alexander 
Published: July 2018

AbstractThe purpose of this study is to investigate the factors that constrain or enable process virtualization in a government‐to‐citizen engagement process. Past research has established that most e‐government projects, especially in developing countries, are regarded as total failure or partial failure. Citizens' unwillingness to use government electronic services and lack of awareness are among some of the reasons why these electronic services fail. Using the process virtualization theory (PVT) as theoretical lens, the authors investigated the various activities within the driver license acquisition process at the Driver and Vehicle Licensing Authority. The PVT helped in identifying factors which enable or inhibit the virtualization of the driver license acquisition process in Ghana. Based on a survey data of 317 participants, we report that process characteristics in the form of relationship requirements affect citizens' willingness toward the use of government virtualized processes. Situating the PVT within a developing country context, our findings reveal that some cultural and behavioral attributes such as socialization hinder the virtualization of some activities within the driver licensing process.