bluuebunny/crossref_metadata_2025_split huggingface dataset:
Veteran‐centred content in medical education
Authors: Ross Paula T , Lypson Monica L 
Published: March 2018

SummaryBackgroundVeterans have unique experiences that warrant special consideration in health care. Unfortunately, training in veteran‐centred care has not been a clear focus of medical education, and only a very small proportion of medical schools include military cultural competency in their curricula.MethodsWe conducted an 80‐minute focus group with six US veterans. Open‐ended questions were used to elicit their perceptions of the health care that they receive, and how it can be improved. The audio‐recording was transcribed verbatim and coded for thematic content. A phenomenological analytic approach was used to analyse the 31‐page transcript and arrive at the final themes.ResultsFormer service members from various periods of conflict (e.g. World War II, Vietnam, Persian Gulf) offered key insights about how to improve veterans’ health care experiences. Veterans suggested that consideration of their previous military service would improve care. They lamented that the lack of military consciousness is a barrier to care. Finally, they suggested that clinicians pay close attention to the transition from service member to civilian, as reintegration to civilian life is a critical life experience.Training in veteran‐centred care has not been a clear focus of medical educationDiscussionVeteran‐centred care ensures optimal health care through ease of access to services, and through positive patient–provider interactions. Being aware of military culture can help providers to contextualise veterans’ experiences and beliefs about health care seeking and illness management, particularly for invisible wounds of war, including traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD).
Aspergillus flavus native valve endocarditis following combined liver and renal transplantation: Case report and review of the literature
Authors: Alsobayeg Sultan , Alshehri Nada , Mohammed Shamayel , Fadel Bahaa M. , Omrani Ali S. , Almaghrabi Reem S. 
Published: March 2018

AbstractAspergillus endocarditis is a rare infection that occurs most commonly in patients with prior cardiac surgery but cases in post‐transplant recipients without prior cardiac surgery have been reported. Diagnosis is often delayed and requires high index of suspicion. We here report a case of Aspergillus endocarditis in solid organ transplant recipient.
Re‐infection of Toxoplasma gondii after HSCT presenting lymphadenopathy resembling recurrence of lymphoma
Authors: Hashiguchi Junichi , Onozawa Masahiro , Naka Tomoaki , Hatanaka Kanako C. , Shiratori Souichi , Sugita Junichi , Fujimoto Katsuya , Matsuno Yoshihiro , Teshima Takanori 
Published: March 2018

AbstractToxoplasma gondii (T. gondii) reactivation is one of the fatal complications after hematopoietic stem cell transplantation (HSCT); however, re‐infection has not been reported. Here, we report a case of mycosis fungoides in which cervical lymphadenopathy developed after HSCT. Initially, recurrent lymphoma was suspected. However, biopsy of the lymph node showed typical histology of toxoplasmosis and serology showed re‐infection of T. gondii. Toxoplasmosis needs to be differentiated for cases with lymphoadenopthy after HSCT.
GreenCut protein CPLD49 of Chlamydomonas reinhardtii associates with thylakoid membranes and is required for cytochrome b6f complex accumulation
Authors: Wittkopp Tyler M. , Saroussi Shai , Yang Wenqiang , Johnson Xenie , Kim Rick G. , Heinnickel Mark L. , Russell James J. , Phuthong Witchukorn , Dent Rachel M. , Broeckling Corey D. , Peers Graham , Lohr Martin , Wollman Francis‐André , Niyogi Krishna K. , Grossman Arthur R. 
Published: March 2018

SummaryThe GreenCut encompasses a suite of nucleus‐encoded proteins with orthologs among green lineage organisms (plants, green algae), but that are absent or poorly conserved in non‐photosynthetic/heterotrophic organisms. In Chlamydomonas reinhardtii, CPLD49 (Conserved in Plant Lineage and Diatoms49) is an uncharacterized GreenCut protein that is critical for maintaining normal photosynthetic function. We demonstrate that a cpld49 mutant has impaired photoautotrophic growth under high‐light conditions. The mutant exhibits a nearly 90% reduction in the level of the cytochrome b6f complex (Cytb6f), which impacts linear and cyclic electron transport, but does not compromise the ability of the strain to perform state transitions. Furthermore, CPLD49 strongly associates with thylakoid membranes where it may be part of a membrane protein complex with another GreenCut protein, CPLD38; a mutant null for CPLD38 also impacts Cytb6f complex accumulation. We investigated several potential functions of CPLD49, with some suggested by protein homology. Our findings are congruent with the hypothesis that CPLD38 and CPLD49 are part of a novel thylakoid membrane complex that primarily modulates accumulation, but also impacts the activity of the Cytb6f complex. Based on motifs of CPLD49 and the activities of other CPLD49‐like proteins, we suggest a role for this putative dehydrogenase in the synthesis of a lipophilic thylakoid membrane molecule or cofactor that influences the assembly and activity of Cytb6f.
Analytical validation of a flow cytometric protocol for quantification of platelet microparticles in dogs
Authors: Cremer Signe E. , Krogh Anne K. H. , Hedström Matilda E. K. , Christiansen Liselotte B. , Tarnow Inge , Kristensen Annemarie T. 
Published: March 2018

BackgroundPlatelet microparticles (PMPs) are subcellular procoagulant vesicles released upon platelet activation. In people with clinical diseases, alterations in PMP concentrations have been extensively investigated, but few canine studies exist.ObjectivesThis study aims to validate a canine flow cytometric protocol for PMP quantification and to assess the influence of calcium on PMP concentrations.MethodsMicroparticles (MP) were quantified in citrated whole blood (WB) and platelet‐poor plasma (PPP) using flow cytometry. Anti‐CD61 antibody and Annexin V (AnV) were used to detect platelets and phosphatidylserine, respectively. In 13 healthy dogs, CD61+/AnV− concentrations were analyzed with/without a calcium buffer. CD61+/AnV−, CD61+/AnV+, and CD61−/AnV+ MP quantification were validated in 10 healthy dogs. The coefficient of variation (CV) for duplicate (intra‐assay) and parallel (inter‐assay) analyses and detection limits (DLs) were calculated.ResultsCD61+/AnV− concentrations were higher in calcium buffer; 841,800 MP/μL (526,000‐1,666,200) vs without; 474,200 MP/μL (278,800‐997,500), P < .05. In WB, PMP were above DLs and demonstrated acceptable (<20%) intra‐assay and inter‐assay CVs in 9/10 dogs: 1.7% (0.5‐8.9) and 9.0% (0.9‐11.9), respectively, for CD61+/AnV− and 2.4% (0.2‐8.7) and 7.8% (0.0‐12.8), respectively, for CD61+/AnV+. Acceptable CVs were not seen for the CD61−/AnV+ MP. In PPP, quantifications were challenged by high inter‐assay CV, overlapping DLs and hemolysis and lipemia interfered with quantification in 5/10 dogs.ConclusionsCalcium induced higher in vitro PMP concentrations, likely due to platelet activation. PMP concentrations were reliably quantified in WB, indicating the potential for clinical applications. PPP analyses were unreliable due to high inter‐CV and DL overlap, and not obtainable due to hemolysis and lipemia interference.
Multicenter in vitro thromboelastography and thromboelastometry standardization
Authors: Goggs Robert , Borrelli Antonio , Brainard Benjamin M. , Chan Daniel L. , de Laforcade Armelle , Goy‐Thollot Isabelle , Jandrey Karl E. , Kristensen Annemarie T. , Kutter Annette , Marschner Clara B. , Rannou Benoît , Sigrist Nadja , Wagg Catherine 
Published: March 2018

AbstractObjectiveTo establish and compare the repeatability and reproducibility of activated thromboelastography (TEG) and thromboelastometry (ROTEM) assays.DesignMulticenter in vitro test standardization.SettingVeterinary academic centers.AnimalsTest samples were obtained from normal, healthy dogs. Sixty identical 5 mL aliquots of canine platelet‐rich plasma collected by apheresis, frozen in 6% dimethyl sulfoxide, were tested initially. Sixty identical 6 mL aliquots of canine fresh frozen plasma with admixed cryoprecipitate were subsequently evaluated.InterventionsNone.Measurements and Main ResultsFrozen study samples, quality controls, reagents, and consumables were distributed to participating centers (7 TEG and 3 ROTEM). TEG centers analyzed study samples with kaolin and tissue factor activated assays; ROTEM centers ran proprietary ellagic acid activated and tissue factor activated assays. All machines underwent quality control prior to sample analysis. Within‐ and between‐center coefficients of variation (CVs) were calculated and compared using Mann–Whitney tests and calculation of intraclass correlation coefficients. Within and between centers, individual parameters for both TEG and ROTEM assays were comparable. Both within‐center and between‐center CVs varied markedly (0.7–120.5% and 1.4–116.5%, respectively) with assay type, instrument, and parameter. CVs for equivalent parameters were not significantly different between the 2 platforms. Intraclass correlation coefficients suggested moderate agreement between centers. In general, individual parameter CVs for platelet‐rich plasma samples were lower in TEG centers, while CVs for canine fresh frozen plasma with admixed cryoprecipitate samples were lower in ROTEM centers.ConclusionsMore variation within and between centers was identified than anticipated, but some parameters such as alpha angle were repeatable and reproducible. Sample types for future multicenter standardization efforts will require further optimization and may need to be adapted separately to each platform. Individual centers using viscoelastic tests for evaluation and management of clinical patients should take steps to minimize preanalytical and analytical sources of variation.
Arthroscopic removal of osteochondral fragments in the dorsal pouch of the proximal intertarsal joint in 29 horses
Authors: Espinosa‐Mur Pablo , Coté Nathalie , Desjardins Marc R. 
Published: March 2018

AbstractObjectiveTo describe the radiographic and surgical findings of horses with osteochondral fragments (OCF) in the proximal intertarsal joint (PIJ) and to detail the technique for arthroscopic fragment retrieval and report outcomes.Study designRetrospective case series.AnimalsTwenty‐nine horses (32 tarsi) with OCF in the PIJ.MethodsMedical records of horses with radiographic evidence of OCF in the PIJ were reviewed. Clinical features, number of fragments, location, arthroscopic appearance, and outcome were recorded. Technical modifications with visual aids specific to this arthroscopic technique are described.ResultsTwenty‐seven horses (93%) had radiographic evidence of osteochondritis dissecans lesions in the tarsocrural joint (TCJ). OCF were most commonly located distal to the medial trochlear ridge of the talus. In all cases, fragments were successfully retrieved with a technique based on exposing the fragments after resection of the proximal intertarsal joint capsule (PIJC). Fragments were visible from the TCJ prior resection of the PIJC in 4 of 32 tarsi. A third portal was created to access fragments located distal to the lateral trochlear ridge in 3 of 32 tarsi. Moderate intra‐articular bleeding occurred when the PIJC was resected in 3 of 32 tarsi. One horse had postoperative swelling that resolved with conservative medical management. All horses with long‐term follow‐up available (16/29) started training or returned to their athletic career.Conclusion and clinical significanceThe arthroscopic technique based on resection of PIJC was effective in retrieving OCF in the PIJ and was associated with minor complications. The clinical relevance of these fragments in the PIJ remains unknown.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: March 2018

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 6, Number 4 Burcu Duman, Bartin University, TurkeyChosang Tendhar, Long Island University (LIU), USAEman ElBealy, Kiing Khalid University, Saudi ArabiaErkut Tutkun, Uludağ University, TurkeyFadime Seçgin, Gaziosmanpaşa University, TurkeyFatih Yazıcı, TurkeyGökhan Gencer, TurkeyHüseyin Eroğlu, Turkeyİbrahim Yaşar Kazu, Firat University, TurkeyIntakhab Khan, King Abdulaziz University, Saudi ArabiaIoannis Syrmpas, University of Thessaly, GreeceIşıl Tanriseven, Mersin University, TurkeyJohn Bosco Azigwe, Bolgatanga Polytechnic, GhanaKadir Yıldız, TurkeyLisa Marie Portugal, Grand Canyon University, USALorna T. Enerva, Polytechnic University of the Philippines, PhilippinesMaria Pavlis Korres, Hellenic Open University, GreeceMark Willems, University of Chichester, TurkeyMehmet Elban, TurkeyMehmet Inan, Marmara University, TurkeyMetin Kaya, TurkeyMurat Taş, TurkeyMurtaza Aykaç, Niğde Ömer Halis Demir University, TurkeyMustafa Gümüş, Bulent Ecevit University, TurkeyMuzaffer Selcuk, TurkeyNecdet Ekinci, TurkeyÖnder Dağlıoğlu, Gaziantep University, TurkeyPirkko Siklander, University of Lapland, FinlandRichard H. Martin, Mercer University, USARichard Penny, University of Washington Bothell, USASadia Batool, Preston University Islamabad, PakistanSelcuk Akpinar, TurkeySerdar Büyükipekçi, TurkeySermin Algul, TurkeySerpil Özdemir, Bartin University, TurkeySimona Savelli, Università degli Studi Guglielmo Marconi, ItalySisi Chen, American University of Health Sciences, USASüleyman Murat Yildiz, Muğla Sıtkı Koçman University, TurkeyTurhan Toros, TurkeyUğur Sönmezoğlu, Pamukkale University, TurkeyVedat Ayan, TurkeyVedat Cinar, TurkeyVeronica Rosa, University Rome, ItalyYerlan Seisenbekov, Kazakh National Pedagogical University, KazakhstanZeynep Dinç, Turkey Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
Agreement Errors in Learner Corpora across CEFR: A Computer-Aided Error Analysis of Greek and Turkish EFL Learners Written Productions
Authors: Can Cem 
Published: March 2018

This paper illustrates the use of learner corpus data (extracted from Cambridge Learner Corpus – CLC) to carry out an error analysis to investigate authentic learner errors and their respective frequencies in terms of types and tokens as well as contexts in which they regularly occur across four distinct proficiency levels, B1-B2; C1-C2, as defined by Common European Framework of Reference for Languages (henceforth CEFR) (Council of Europe, 2001). As a variety of learner corpora compiled by researchers become relatively accessible, it is possible to explore interlanguage errors and conduct error analysis (EA) on learner-generated texts. The necessity to cogitate over these authentic learner errors in designing foreign language learning programs and remedial teaching materials has been widely emphasized by many researchers (see e.g., Juozulynas, 1994; Mitton, 1996; Cowan, Choi, & Kim, 2003; Ndiaye & Vandeventer Faltin, 2003; Allerton et al., 2004). This study aims at conducting a corpus-based error analysis of agreement errors to reveal the related error categories between Greek and Turkish EFL learners, the distribution of agreement errors along the B1 - C2 proficiency range according to CEFR, and the distribution of agreement error types in respect of the L1 of the learners. The data analyzed in this study is extracted from the Cambridge Learner Corpus (CLC), the largest annotated test performance corpus which enables the investigation of the linguistic and rhetorical features of the learner performances in the above stated proficiency bands. The findings from this study reveal that, across B1-C2 proficiency levels and across different registers and genres, the most common agreement error categories by the frequency in which they occur are Verb Agreement (AGV), Noun Agreement (AGN), Anaphor Agreement (AGA), Determiner Agreement (AGD), Agreement Error (AG), and Quantifier Agreement (AGQ) errors. This study’s approach uses the techniques of computer corpus linguistics and follows the steps of the Error Analysis framework proposed by Corder (1971): identification, description, classification and explanation of errors.
Metaboreceptor activation in heart failure with reduced ejection fraction: Linking cardiac and peripheral vascular haemodynamics
Authors: Barrett‐O'Keefe Zachary , Lee Joshua F. , Berbert Amanda , Witman Melissa A. H. , Nativi‐Nicolau Jose , Stehlik Josef , Richardson Russell S. , Wray D. Walter 
Published: March 2018

New Findings
What is the central question of this research?
Do patients with heart failure with reduced ejection fraction (HFrEF) exhibit a greater dependence on cardiac or peripheral vascular haemodynamics across multiple levels of muscle metaboreflex activation provoked by postexercise circulatory occlusion?

What is the main finding and its importance?
The metaboreflex‐induced pressor response in HFrEF patients is governed almost entirely by the peripheral circulation, which places a substantial haemodynamic load on the failing heart. This maladaptive response exacerbates the disease‐related impairment of systolic function that is a hallmark feature of HFrEF and may therefore contribute to exercise intolerance in this patient group.

AbstractWe sought to evaluate the muscle metaboreflex in heart failure with reduced ejection fraction (HFrEF) patients, with an emphasis on the interaction between cardiac and peripheral vascular haemodynamics across multiple levels of metaboreceptor activation. In 23 HFrEF patients (63 ± 2 years of age) and 15 healthy control subjects (64 ± 3 years of age), we examined changes in mean arterial pressure, cardiac output, systemic vascular conductance, effective arterial elastance, stroke work and forearm deoxyhaemoglobin concentration during metaboreceptor activation elicited by postexercise circulatory occlusion (PECO) after three levels of static‐intermittent handgrip exercise (15, 30 and 45% maximal voluntary contraction). Across workloads, the metaboreflex‐induced increase in deoxyhaemoglobin and mean arterial pressure were similar between groups. However, in control subjects, the pressor response was driven by changes (Δ) in cardiac output (Δ495 ± 155, Δ564 ± 156 and Δ666 ± 217 ml min−1), whereas this change was accomplished by intensity‐dependent reductions in systemic vascular conductance in patients with HFrEF (Δ−4.9 ± 1.5, Δ−9.1 ± 1.9 and Δ−12.7 ± 1.8 ml min mmHg−1). This differential response contributed to the exaggerated increases in effective arterial elastance in HFrEF patients compared with control subjects, coupled with a blunted response in stroke work in the HFrEF patients. Together, these findings indicate a preserved role of the metaboreflex‐induced pressor response in HFrEF but suggest that this response is governed by changes in the peripheral circulation. The net effect of this response appears to be maladaptive, as it places a substantial haemodynamic load on the left ventricle that may exacerbate left ventricular systolic dysfunction and contribute to exercise intolerance in this patient population.
Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient
Authors: Ridler Thomas , Matthews Peter , Phillips Keith G. , Randall Andrew D. , Brown Jonathan T. 
Published: March 2018

Key points
The medial entorhinal cortex (mEC) has an important role in initiation and propagation of seizure activity. Several anatomical relationships exist in neurophysiological properties of mEC neurons; however, in the context of hyperexcitability, previous studies often considered it as a homogeneous structure.
Using multi‐site extracellular recording techniques, ictal‐like activity was observed along the dorso‐ventral axis of the mEC in vitro in response to various ictogenic stimuli. This originated predominantly from ventral areas, spreading to dorsal mEC with a surprisingly slow velocity.
Modulation of inhibitory tone was capable of changing the slope of ictal initiation, suggesting seizure propagation behaviours are highly dependent on levels of GABAergic function in this region.
A distinct disinhibition model also showed, in the absence of inhibition, a prevalence for interictal‐like initiation in ventral mEC, reflecting the intrinsic differences in mEC neurons.
These findings suggest the ventral mEC is more prone to hyperexcitable discharge than the dorsal mEC, which may be relevant under pathological conditions.
AbstractThe medial entorhinal cortex (mEC) has an important role in the generation and propagation of seizure activity. The organization of the mEC is such that a number of dorso‐ventral relationships exist in neurophysiological properties of neurons. These range from intrinsic and synaptic properties to density of inhibitory connectivity. We examined the influence of these gradients on generation and propagation of epileptiform activity in the mEC. Using a 16‐shank silicon probe array to record along the dorso‐ventral axis of the mEC in vitro, we found 4‐aminopyridine application produces ictal‐like activity originating predominantly in ventral areas. This activity spreads to dorsal mEC at a surprisingly slow velocity (138 μm s−1), while cross‐site interictal‐like activity appeared relatively synchronous. We propose that ictal propagation is constrained by differential levels of GABAergic control since increasing (diazepam) or decreasing (Ro19‐4603) GABAA receptor activation, respectively, reduced or increased the slope of ictal initiation. The observation that ictal activity is predominately generated in ventral mEC was replicated using a separate 0‐Mg2+ model of epileptiform activity in vitro. By using a distinct disinhibition model (co‐application of kainate and picrotoxin) we show that additional physiological features (for example intrinsic properties of mEC neurons) still produce a prevalence for interictal‐like initiation in ventral mEC. These findings suggest that the ventral mEC is more likely to initiate hyperexcitable discharges than the dorsal mEC, and that seizure propagation is highly dependent on levels of GABAergic expression across the mEC.