bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does online insomnia treatment reduce depressive symptoms? A randomized controlled trial in individuals with both insomnia and depressive symptoms
Authors: van der Zweerde T. , van Straten A. , Effting M. , Kyle S. D. , Lancee J. 
Published: May 2018

AbstractBackgroundInsomnia is effectively treated with online Cognitive Behavioral Therapy for Insomnia (CBT-I). Previous research has suggested the effects might not be limited to sleep and insomnia severity, but also apply to depressive symptoms. Results, however, are mixed.MethodsIn this randomized controlled trial we investigated the effects of guided online CBT-I on depression and insomnia in people suffering from symptoms of both. Participants (n= 104) with clinical insomnia and at least subclinical depression levels were randomized to (1) guided online CBT-I and sleep diary monitoring (i-Sleep) or (2) control group (sleep diary monitoring only). The primary outcome was the severity of depressive symptoms (Patient Health Questionnaire-9 without sleep item; PHQ-WS). Secondary outcomes were insomnia severity, sleep diary parameters, fatigue, daytime consequences of insomnia, anxiety, and perseverative thinking.ResultsAt post-test, participants in the i-Sleep condition reported significantly less depressive symptoms (PHQ-WS) compared with participants in the sleep-diary condition (d= 0.76). Large significant effects were also observed for insomnia severity (d= 2.36), most sleep diary parameters, daytime consequences of insomnia, anxiety, and perseverative thinking. Effects were maintained at 3 and 6 month follow-up. We did not find significant post-test effects on fatigue or total sleep time.ConclusionsFindings indicate that guided online CBT-I is not only effective for insomnia complaints but also for depressive symptoms. The effects are large and comparable with those of depression therapy. Clinical trial registration number: NTR6049 (Netherlands Trial Register).
Copper chaperone blocks amyloid formation via ternary complex
Authors: Horvath Istvan , Werner Tony , Kumar Ranjeet , Wittung-Stafshede Pernilla 
Published: May 2018

AbstractProtein misfolding in cells is avoided by a network of protein chaperones that detect misfolded or partially folded species. When proteins escape these control systems, misfolding may result in protein aggregation and amyloid formation. We here show that aggregation of the amyloidogenic protein α-synuclein (αS), the key player in Parkinson's disease, is controlled by the copper transport protein Atox1 in vitro. Copper ions are not freely available in the cellular environment, but when provided by Atox1, the resulting copper-dependent ternary complex blocks αS aggregation. Because the same inhibition was found for a truncated version of αS, lacking the C-terminal part, it appears that Atox1 interacts with the N-terminal copper site in αS. Metal-dependent chaperoning may be yet another manner in which cells control its proteome.
CONSUMPTION AND SOCIAL CHANGE
Authors: Hassoun Nicole 
Published: May 2018

Abstract:How should consumers exercise their basic economic powers? Recently, several authors have argued that consumption to bring about social change must be democratic. Others maintain that we may consume in ways that we believe promote positive change. This paper rejects both accounts and provides a new alternative. It argues that, under just institutions, people may consume as they like as long as they respect the institutions’ rules. Absent just institutions, significant moral constraints on consumption exist. Still, it is permissible, if not obligatory, for people to pursue non-democratic, genuinely positive, change within whatever moral constraints exist.
Reduced plant fitness by pre-dispersal seed predation in the threatened plant species Cirsium decussatum
Authors: Stachurska-Swakoń Alina , Barabasz-Krasny Beata , Klasa Anna , Palaczyk Andrzej 
Published: May 2018

AbstractSeed predation has been suggested to play a crucial role in plant population dynamics and could act as a strong selective force in the evolution of plant traits such as plant phenology, size and number of flowers. The loss of seeds could be particularly threatening for population maintenance of rare plant species. We investigated the influence of seed predators on plant fitness of the rare monocarpic thistle Cirsium decussatum. We tested the following hypotheses: (1) pre-dispersal seed predators reduce the number of dispersed propagules; (2) seed predators select larger inflorescences as oviposition sites; (3) the size of the capitulum is correlated with seed productivity; and (4) seed predators compete for the oviposition sites. We identified ten insect taxa from different taxonomic groups in the capitula of C. decussatum. Terellia longicauda larvae (Diptera: Tephritidae) were the most common. The presence of the flies’ larvae was positively correlated with the predation level in the capitula. Females of T. longicauda selected larger inflorescences for laying eggs that may increase offspring fitness as larger inflorescences promise more food resources. We could not prove the presence of competition between insect species inhabiting the capitula. Our data suggest, however, that T. longicauda, a specialized seminophagous dipteran, is one of the factors that negatively influence the fitness of threatened C. decussatum, lowering significantly the seed pool. Terellia longicauda potentially acts as a strong selective force in the evolution of C. decussatum inflorescence size.
Earth flows and lively stone. What differences does ‘vibrant’ matter make?
Authors: Cipolla Craig N. 
Published: May 2018

AbstractThis essay differentiates between various branches of post-human scholarship as they relate to issues of colonial inequality, social action and politics. Through their critique of human exceptionalism, through their recognition of the vibrancy of matter, and in theirpotentialconnections with politically engaged scholarship, certain lines of post-humanist thought stand to make important contributions to archaeologies of long-term and colonial Indigenous history. I argue that these qualities offer nuanced perspectives on the plural colonial past and present of New England (north-eastern North America). I explore the prospects for a selectively post-human and pragmatic archaeology in connection with recent debates over stone landscapes. This approach makes room for various stakeholder narratives, finding possible common ground in a shared human condition between stakeholders, i.e. subject to ‘earth flows and lively stone’.
The precarious conviviality of watermills
Authors: Given Michael 
Published: May 2018

AbstractSocial institutions such as the water-powered grain mills of Ottoman Cyprus are elaborately interconnected with a wide range of human and non-human players, from millers and villagers to water, gradient, stone and climate. When participants recognize their mutual dependencies and operate according to social and environmental limits, then following Ivan Illich we can call these watermills convivial tools. The European-owned sugar plantations, mills and refineries of medieval Cyprus, by contrast, divided and alienated their workforce, and their demands for water, labour, soil and fuel surpassed what their landscape and society could provide. They are, then, unconvivial tools. Conviviality is always precarious: it needs continual negotiation, conflict and compromise, as well as an acceptance of the mutual dependence of all participants, non-human and human. This politics of conviviality is particularly urgent in times of social and ecological crisis.
Agency (again). A response to Lindstrøm and Ribeiro
Authors: Sørensen Tim Flohr 
Published: May 2018

AbstractIn this reaction article I reflect on criticism raised by Torill Christine Lindstrøm and Artur Ribeiro in recent issues of this journal. I attempt to identify the source of our disagreement, and focus on three particular aspects of their previous reactions: (1) their framing of agency in Alfred Gell and symmetrical archaeology, (2) their basis for declaring symmetrical archaeology redundant and (3) their identification of the terminology of symmetrical archaeology as inflated and crammed with ‘buzzwords’ and ‘neologisms’.
Interval-based resource usage verification by translation into Horn clauses and an application to energy consumption
Authors: LOPEZ-GARCIA P. , DARMAWAN L. , KLEMEN M. , LIQAT U. , BUENO F. , HERMENEGILDO M. V. 
Published: May 2018

AbstractMany applications require conformance with specifications that constrain the use of resources, such as execution time, energy, bandwidth, etc. We present a configurable framework for static resource usage verification where specifications can include data size-dependent resource usage functions, expressing both lower and upper bounds. Ensuring conformance with respect to such specifications is an undecidable problem. Therefore, to statically check such specifications, our framework infers the same type of resource usage functions, which safely approximate the actual resource usage of the program, and compares them against the specification. We review how this framework supports several languages and compilation output formats by translating them to an intermediate representation based on Horn clauses and using the configurability of the framework to describe the resource semantics of the input language. We provide a detailed formalization and extend the framework so that both resource usage specification and analysis/verification output can include preconditions expressing intervals for the input data sizes for which assertions are intended to hold, proved, or disproved. Most importantly, we also extend the classes of functions that can be checked. We also report on and provide results from an implementation within the Ciao/CiaoPP framework, as well as on a practical tool built by instantiating this framework for the verification of energy consumption specifications for imperative/embedded programs. Finally, we show as an example how embedded software developers can use this tool, in particular, for determining values for program parameters that ensure meeting a given energy budget while minimizing the loss in quality of service.
Combination between Ca, P and Y in the Martian Meteorite NWA 6963 could be used as a strategy to indicate liquid water reservoirs on ancient Mars?
Authors: do Nascimento-Dias Bruno Leonardo 
Published: May 2018

AbstractAlthough we have learned much about the geological characteristics and history of Mars, the gaps in our knowledge certainly exceed what we understand. Martian meteorites, such as Northwest Africa (NWA) 6963, can be excellent materials for understanding the present and past of Mars, as part of the records of the planet's evolution is preserved in these extraterrestrial rocks. Micro X-ray fluorescence provided data, in which it was possible to verify the presence of Ca, P and Y elements, which are call attention because they were detected superimposed in certain regions. The way these elements were detected indicates the formation of minerals composed by the combination of these elements, such as, for example, Calcite (CaCO3), Apatite [Ca5(PO4)3(OH, F, Cl)], Merrilite [Ca9NaMg (PO4)7] and Xenotime (YPO4). These minerals are great indicators of aqueous environments. In general, the formation of these minerals is due to processes involving hydrothermal fluids or sources (>100 °C). Some geological indications suggest that in the past there might have been a large amount of liquid water, which could have accumulated large reservoirs below the Martian surface. Thus, the laboratory study of Martian meteorites and interpretations of minerals present in these samples can contribute in a complementary way to the existing results of telescopic observations and/or missions of space probes as a strategy to indicate reservoirs of liquid water.
Exploring the associations between spiritual well-being, burden, and quality of life in family caregivers of cancer patients
Authors: Spatuzzi Roberta , Giulietti Maria Velia , Ricciuti Marcello , Merico Fabiana , Fabbietti Paolo , Raucci Letizia , Bilancia Domenico , Cormio Claudia , Vespa Anna 
Published: May 2018

AbstractObjectiveThe spiritual dimension is important in the process of coping with stress and may be of special relevance for those caring for cancer patients in the various phases of caregivership, although current attention is most prevalent at the end of life. This study explores the associations among spiritual well-being (SWB), caregiver burden, and quality of life (QoL) in family caregivers of patients with cancer during the course of the disease.MethodThis is a cross-sectional study. All participants (n = 199) underwent the following self-report questionnaires: the SWB-Index, the Medical Outcomes Study Short Form, and the Caregiver Burden Inventory (CBI). SWB scores were dichotomized at a cutoff corresponding to the 75th percentile. Statistical analyses were made using the Student t or by chi-square test to compare high and low SWB groups.ResultThe high SWB group reported significantly better Medical Outcomes Study Short Form scores in bodily pain (p = 0.035), vitality (p &lt; 0.001), social activities (p = 0.001), mental health (p &lt; 0.001), and in standardized mental component subscales (p &lt; 0.001) than the low SWB group. No significant differences were detected between the two SWB groups in physical activity, physical role, general health, emotional status, and standardized physical component scale. The high SWB group also had better CBI scores in the physical (p = 0.049) and developmental burden (p = 0.053) subscales. There were no significant differences in the other CBI scores (overall and sections).Significance of resultsThis study points out that high SWB caregivers have a more positive QoL and burden. Knowledge of these associations calls for more attention on the part of healthcare professionals toward spiritual resources among family cancer caregivers from the moment of diagnosis and across the entire cancer trajectory.
What the City Has to Offer: Urbanization and Women's Empowerment in Turkey
Authors: Cinar Kursat , Ugur-Cinar Meral 
Published: May 2018

AbstractThis article examines the relationship between urbanization and women's empowerment through the Turkish case. The article first tests statistically the overall impact of urbanization on women's empowerment by tapping into educational, economic, and political indicators at the province level. The results yield a positive relationship between urbanization and women's empowerment. We argue that these empowerment indicators demonstrate the necessary conditions of women's empowerment, yet whether these are sufficient for women to feel empowered needs to be further tested. To do so, the article utilizes an extensive original survey of 334 well-educated urban women in 43 out of 81 provinces of Turkey to examine the extent to which the results found in the quantitative section are paralleled by the actual experiences of women. The survey analysis reveals prospects and obstacles that well-educated women face in old and new urban centers. This nonrandom, purposive sample of seemingly empowered urban women shows that the barriers faced by these women would easily multiply when lower strata of society are reached. The Turkish case demonstrates that societal transformations such as urbanization have an imprint on the fates of women, yet further women's empowerment needs collective action at the political, legal, and societal levels.
Yet more on a stochastic economic model: Part 5: a vector autoregressive (VAR) Model for retail prices and wages
Authors: Wilkie A. D. , Şahin Şule 
Published: May 2018

AbstractIn this paper we develop a vector autoregressive model for retail prices and wages within the Wilkie model. The results turn out to be a slight improvement over the original model, but the simulated results are not very different.
What Makes Us Feel Good or Bad
Authors: Schmidt Barbara , Warns Luise , Hellmer Meike , Ulrich Natalie , Hewig Johannes 
Published: May 2018

Abstract. Affective science calls for methods to induce mood in an engaging and ecologically valid way. We present a method employing a naturally occurring scenario that fits these criteria: a job interview. Participants got positive or negative feedback from a fictive expert to induce positive or negative mood. After mood induction, we assessed participants’ decision making behavior in the so-called information sampling task (IST). Results show that our mood induction successfully changed valence, dominance, and state self-esteem ratings, while there were no differences in arousal ratings. Decision making in the IST was not influenced by the induced mood. Effect sizes of mood induction were equally high for positive and negative mood concerning valence ratings (d = .8) with participants scoring high on self-control showing smaller mood induction effects. We conclude that our mood induction technique is an effective and natural way to induce mood in the laboratory, meeting current criteria of affective science.
Increasing Methane Emissions From Natural Land Ecosystems due to Sea‐Level Rise
Authors: Lu Xiaoliang , Zhou Yuyu , Zhuang Qianlai , Prigent Catherine , Liu Yaling , Teuling Adriaan 
Published: May 2018

AbstractAtmospheric methane (CH4) is one of the most important greenhouse gases. However, there is still a large uncertainty in simulating CH4 emissions from terrestrial ecosystems. Different from modeling studies focusing on response of CH4 emissions to various environmental changes in land ecosystems, this study analyzed the response of CH4 emissions to sea‐level rise (SLR). To do so, a large‐scale surface water routing module was incorporated into an existing CH4 model. This allowed the model to simulate the effect of SLR on river flows and inland water levels. This study focused on these freshwater systems and did not address saltwater intrusion or coastal wetland impacts. Both the annual maximum inundation extent and CH4 emissions at the global level showed a steadily growing trend, with an increase of 1.21 × 105 km2 in extent and an increase of 3.13 Tg CH4/year in CH4 emissions, in a 22‐year SLR experiment from 1993 to 2014. Most of new inundation and methane source areas were located near rivers' deltas and along downstream reaches of rivers. The increase in the inundation extent is primarily influenced by precipitation, channel geomorphic characteristics, and topography of riverside area. The increase of CH4 emissions due to the SLR is largely determined by the inundation extent, but other factors such as air temperature and carbon storage also play roles. Although the current SLR‐induced increases in the inundation extent and CH4 emissions only accounted for 1.0% and 1.3% of their global totals, these increases contributed 7.0% and 17.3% of the mean annual variability in both, respectively, during the study period. Considering that SLR has a long‐term increasing trend, future SLR under a changing climate could play a more important role in global CH4 emissions.
Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα
Authors: Rosato Benedetta , Ranieri Danilo , Nanni Monica , Torrisi Maria Rosaria , Belleudi Francesca 
Published: May 2018

AbstractThe tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular contexts, including keratinocytes. Therefore, in this paper we propose to clarify if FGFR2b could play a role also in the late steps of keratinocyte differentiation and to assess if this receptor-induced process would sequentially involve PKCδ and PKCα isoforms. Immunofluorescence, biochemical, and molecular approaches, performed on 2D cultures or 3D organotypic rafts of human keratinocytes overexpressing FGFR2b by stable transduction, showed that receptor signaling induced the precocious onset and an accelerated progression of keratinocyte differentiation, indicating that FGFR2b is a crucial regulator of the entire program of keratinocyte differentiation. In addition, the use of specific inhibitors and gene silencing approaches through specific siRNA demonstrated that PKCδ controls the onset of FGFR2b-triggered differentiation, while PKCα plays a role restricted to the terminal stages of the process. Molecular analysis revealed that the two PKC isoforms sequentially act via induction of KLF4 and DLX3, two transcription factors linked by negative loops to p63, suggesting that p63 would represent the hub molecule at the crossroad of an intricate signaling network downstream FGFR2b, involving multiple PKC-induced transcription factors.
PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing
Authors: Liang Xin , Chen Weixia , Shi Haiyang , Gu Xiangyu , Li Yueqi , Qi Yingxue , Xu Ke , Zhao Aiguang , Liu Jianwen 
Published: May 2018

AbstractPolypyrimidine tract-binding protein 3 (PTBP3) is an essential RNA-binding protein with roles in RNA splicing, 3′ end processing and translation. Although increasing evidence implicates PTBP3 in several cancers, its role in gastric cancer metastasis remains poorly explored. In this study, we found that PTBP3 was upregulated in the gastric cancer tissues of patients with lymph node metastasis. Patients with high PTBP3 expression levels had significantly shorter survival than those with low PTBP3 expression. Overexpression/knockdown of PTBP3 expression had no effect on proliferation, whereas it regulated migration and invasion in vitro. In addition, when a mouse xenotransplant model of MKN45 was established, knockdown of PTBP3 in MKN45 cells caused the formation of tumours that were smaller in size than their counterparts, with suppression of tumour lymphangiogenesis and metastasis to regional lymph nodes. Furthermore, we identified caveolin 1 (CAV1) as a downstream target of PTBP3. RNA immunoprecipitation (RIP) assays and dual-luciferase reporter gene assays indicated that PTBP3 interacted with the CU-rich region of the CAV1 gene to downregulate CAV1α expression. Knockdown of CAV1α abrogated the reduction of FAK and Src induced by PTBP3 knockdown. In summary, our findings provide experimental evidence that PTBP3 may function as a metastatic gene in gastric cancer by regulating CAV1 through alternative splicing.
Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina
Authors: Comitato Antonella , Subramanian Preeti , Turchiano Giandomenico , Montanari Monica , Becerra S. Patricia , Marigo Valeria 
Published: May 2018

AbstractCalcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF) is a promising neuroprotective protein for photoreceptor cells but the mechanisms mediating its effects against retinal degeneration are still not well characterized. We addressed this question in the rd1 degenerating mouse retina that bears a mutation in the Pde6b gene encoding one subunit of the phosphodiesterase enzyme. Loss of phosphodiesterase activity in rod photoreceptor cells increases cyclic guanosine monophosphate (cGMP) levels leading to a rise in intracellular calcium. Short-term treatments with recombinant human PEDF protein decreased intracellular calcium in photoreceptors in vivo. Taking advantage of calcium pump blockers, we defined that PEDF signaling acts on PMCA calcium pumps to lower intracellular calcium. PEDF restrained cell death pathways activated by high calcium levels and engaging calpains, BAX and AIF. The neurotrophic effects were mediated by the PEDF receptor (PEDF-R), encoded by the PNPLA2 gene. Finally, peptides containing the neurotrophic domain of PEDF targeted these same cell death pathways in vivo. The findings reveal rescue from death of degenerating photoreceptor cells by a PEDF-mediated preservation of intracellular calcium homeostasis.