bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health effects of desert dust and sand storms: a systematic review and meta-analysis protocol
Authors: Tobias Aurelio , Karanasiou Angeliki , Amato Fulvio , Roqué Marta , Querol Xavier 
Published: July 2019

IntroductionDesert dust concentrations raise concerns about adverse effects on human health. During the last decade, special attention has been given to mineral dust particles from desert dust and sand storms. However, evidence from previous reviews reported inconclusive results on their health effects and the biological mechanism remains unclear. We aim to systematically synthesise evidence on the health effects of desert dust and sand storms accounting for the relevant desert dust patterns from source areas and emissions, transport and composition.Methods an analysisWe will conduct a systematic review that investigated the health effects of desert dust and sand storms in any population. The search will be performed for any eligible studies from previous reviews and selected electronic databases until 2018. Study selection and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data from individual studies will be extracted using a standardised data extraction form. Quality of the studies will be assessed using a risk of bias tool for environmental exposures developed by experts convened by the WHO. A meta-analysis will be performed by calculating the appropriate effect measures of association for binary and continuous outcomes from individual studies. Subgroup analyses will be performed by geographical areas to account for desert dust patterns.Ethics and disseminationNo primary data will be collected. For this reason, no formal ethical approval is required. This systematic review will help to fill the research gaps in the knowledge of desert dust on human health. The results will be disseminated through a WHO peer-reviewed publication and a conference presentation.PROSPERO registration numberCRD42018091809
Economics of abortion: a scoping review protocol
Authors: Coast Ernestina , Lattof Samantha R , van der Meulen Rodgers Yana , Moore Brittany 
Published: July 2019

IntroductionAbortion is a common feature of people’s reproductive lives. However, the economic implications of abortion and policies affecting abortion provision are poorly understood. This scoping review aims to systematically review social science literature for studies that have investigated the impact of abortion care (ie, un/safe abortion, post-abortion care) or abortion policies on economic outcomes at the micro-levels (ie, abortion seekers and their households), meso-levels (ie, communities and health systems) and macro-levels (ie, societies and nation states). Informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guideline for protocols, this protocol details the scoping review’s methodological and analytical approaches.Methods and analysisThis scoping review will utilise the PRISMA extension for Scoping Reviews (PRISMA-ScR) tool. Studies reporting on qualitative and/or quantitative data from any world region will be considered. For inclusion, studies must examine one of the following economic outcomes at the micro-levels, meso-levels and/or macro-levels: costs, benefits, impacts and/or value of abortion care or abortion policies. Searches will be conducted in eight electronic databases. We will conduct the searches and application of inclusion/exclusion criteria according to the PRISMA-ScR flow approach. No assessments of items’ quality will be made, as the purpose of this scoping review is to synthesise and describe the coverage of the evidence. After extracting all data, we will inductively develop an economic framework around the economics of abortion. The analysis will synthesise the evidence base and identify knowledge gaps on the costs and benefits of abortion to stakeholders at various levels.Ethics and disseminationFormal ethical approval is not required, as primary data will not be collected in this study. The findings of this study will be disseminated through peer-reviewed publications, conference presentations, and condensed summaries for key stakeholders and partners in the field.
Sex differences in the association of risk factors for heart failure incidence and mortality
Authors: Sillars Anne , Ho Frederick K , Pell Gill P , Gill Jason M R , Sattar Naveed , Gray Stuart , Celis-Morales Carlos 
Published: July 2019

BackgroundThere are known risk factors associated with the development of heart failure (HF), but it is not fully understood whether these differ by sex.ObjectivesTo investigate sex differences in risk factors for HF incidence and mortality.Methods468 941 participants (55.9% women, age range 37–73 years) were included. Established CVD risk factors (hypertension, hypercholesterolaemia, diabetes type 1 and 2, adiposity, smoking, physical activity and poor diet) and novel risk factors (grip strength, fitness, TV viewing and sleep duration) were the exposures of interest. HF incidence and mortality were the outcomes.ResultsOver a mean follow-up of 9.0 years, 1812 participants developed HF and 763 died due to HF. Women with type 1 diabetes (T1DM), type 2 diabetes (T2DM), hypertension, hypercholesterolaemia, low levels of physical activity and fitness, low strength, high levels of TV viewing, sleep duration <7 hours/day, smokers; those who were underweight and who were obese, had high body surface area and those who drink >14 units of alcohol were at higher risk of HF incidence. However, in women T2DM, hypercholesterolaemia, >3 hours/day of TV and sleep <7 hours/day, low level of physical activity and high level of TV viewing were more strongly associated with HF incidence compared with men.ConclusionSeveral modifiable risk factors (in particular diabetes) appear more strongly associated with HF in women compared with men. The relevance of these findings to HF characteristics and future outcomes needs to be established.
Disparities in Socioeconomic Context and Association With Blood Pressure Control and Cardiovascular Outcomes in ALLHAT
Authors: Shahu Andi , Herrin Jeph , Dhruva Sanket S. , Desai Nihar R. , Davis Barry R. , Krumholz Harlan M. , Spatz Erica S. 
Published: July 2019

Background
Observational studies demonstrate that communities of low socioeconomic status have higher blood pressure and worse cardiovascular outcomes. Yet, whether the clinical outcomes resulting from antihypertensive therapy vary by socioeconomic context in a randomized clinical trial, in which participants are treated under a standard protocol, is unknown.

Methods and Results

We used data from ALLHAT (Antihypertensive and Lipid‐Lowering Treatment to Prevent Heart Attack Trial) to study the effect of socioeconomic context, defined as the county‐level median household income, of study sites. We stratified sites into income quintiles and compared characteristics, blood pressure control, and cardiovascular outcomes among
ALLHAT
participants in the lowest‐ and highest‐income quintiles. Among 27 862 qualifying participants, 2169 (7.8%) received care in the lowest‐income sites (quintile 1) and 10 458 (37.6%) received care in the highest‐income sites (quintile 5). Participants in quintile 1 were more likely to be women, to be black, to be Hispanic, to have fewer years of education, to live in the South, and to have fewer cardiovascular risk factors. After adjusting for baseline demographic and clinical characteristics, quintile 1 participants were less likely to achieve blood pressure control (<140/90 mm Hg) (odds ratio, 0.48; 95%
CI
, 0.37–0.63) and had greater all‐cause mortality (hazard ratio [HR], 1.25; 95%
CI
, 1.10–1.41), heart failure hospitalizations/mortality (
HR
, 1.26; 95%
CI
, 1.03–1.55), and end‐stage renal disease (
HR
, 1.86; 95%
CI
, 1.26–2.73), but lower angina hospitalizations (
HR
, 0.70; 95%
CI
, 0.59–0.83) and coronary revascularizations (
HR
, 0.71; 95%
CI
, 0.57–0.89).

Conclusions

Despite standardized treatment protocols,
ALLHAT
participants in the lowest‐income sites experienced poorer blood pressure control and worse outcomes for some adverse cardiovascular events, emphasizing the importance of measuring and addressing socioeconomic context.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
00000542.
Making the Transition from Science Delivery to Knowledge Coproduction in Boundary Spanning: A Case Study of the Alaska Fire Science Consortium
Authors: Colavito Melanie M. , Trainor Sarah F. , Kettle Nathan P. , York Alison 
Published: July 2019

Abstract
Boundary organizations facilitate two-way, sustained interaction and communication between research and practitioner spheres, deliver existing science, and develop new, actionable scientific information to address emerging social–ecological questions applicable to decision-making. There is an increasing emphasis on the role of boundary organizations in facilitating knowledge coproduction, which is collaborative research with end users to develop actionable scientific information for decision-making. However, a deeper understanding of how boundary organizations and knowledge coproduction work in practice is needed. This paper examines the Alaska Fire Science Consortium (AFSC), a boundary organization focused on fire science and management in Alaska that is working to address climate impacts on wildfire. A case study approach was used to assess AFSC activities over time. AFSC’s boundary spanning involves a continuum of outputs and activities, but their overall trajectory has involved a deliberate transition from an emphasis on science delivery to knowledge coproduction. Key factors that facilitated this transition included a receptive and engaged audience, built-in evaluation and learning, subject matter expertise and complementarity, and embeddedness in the target audience communities. Recommendations for boundary organizations wishing to develop knowledge coproduction capacity include knowing your audience, employing trusted experts in boundary spanning, and engaging in frequent self-evaluation to inform change over time.
Measuring Tornado Warning Reception, Comprehension, and Response in the United States
Authors: Ripberger Joseph T. , Krocak Makenzie J. , Wehde Wesley W. , Allan Jinan N. , Silva Carol , Jenkins-Smith Hank 
Published: July 2019

AbstractSocial criteria are important to achieving the mission of the National Weather Service. Accordingly, researchers and administrators at the NWS increasingly recognize a need to supplement verification statistics with complementary data about society in performance management and evaluation. This will require significant development of new capacities to both conceptualize relevant criteria and measure them using consistent, transparent, replicable, and reliable measures that permit generalizable inference to populations of interest. In this study, we contribute to this development by suggesting three criteria that require measurement (forecast and warning reception, comprehension, and response) and demonstrating a methodology that allows us to measure these concepts in a single information domain—tornado warnings. The methodology we employ improves upon previous research in multiple ways. It provides a more generalizable approach to measurement using a temporally consistent set of survey questions that are applicable across the United States; it relies on a more robust set of psychometric tests to analytically demonstrate the reliability of the measures; and it is more transparent and replicable than previous research because the data and methods (source code) are publicly available. In addition to describing and assessing the reliability of the measures, we explore the sensitivity of the measures to geographic and demographic variation to identify significant differences that require attention in measurement. We close by discussing the implications of this study and the next steps toward development and use of social criteria in performance management and evaluation.
Immunosuppressive therapies adversely affect blood biochemical parameters in patients with inflammatory bowel disease: a meta-analysis
Authors: Wang Xiaobing , Wang Ge , Shang Jian , Pan Huaqin , Zhang Xin A , Zhou Feng 
Published: July 2019

Objective This study was performed to investigate whether a definite correlation exists between alteration of blood biochemical parameters and immunosuppressive therapies in patients with inflammatory bowel disease (IBD). Methods A comprehensive search of PubMed, EMBASE, MEDLINE, and the Cochrane Library was conducted. Data on alterations in white blood cells, platelets, hemoglobin, serum creatinine, and liver enzymes in patients with IBD treated with immunomodulators were extracted. Results Data from 1141 patients were included. The relative risk (RR) of leukopenia was significantly higher in the immunosuppressive therapies group than in the placebo group (RR, 12.91; 95% confidence interval [CI], 5.28–31.57). A statistically significant risk of leukocytosis during immunosuppressive therapies was observed (RR, 1.53; 95% CI, 1.05–2.23). Patients taking immunomodulators had increased risks of serum creatinine elevation (RR, 10.68; 95% CI, 2.07–55.12) and serum aminotransferase elevation (RR, 3.18; 95% CI, 1.24–8.17). Conclusion Immunosuppressive therapies might have an impact on variations in blood biochemical parameters in patients with IBD. Although the conclusion regarding leukopenia was reliable in this study, some confounding factors might reduce the reliability of the conclusions about leukocytosis, creatinine elevation, and aminotransferase elevation. Close monitoring is recommended during immunosuppressive therapies for IBD.
Characteristics of Hospitalized Patients Screening Positive for Delirium
Authors: Nguyen Trinh H. , Atayee Rabia S. , Derry Katrina L. , Hirst Jeremy , Biondo Anthony , Edmonds Kyle P. 
Published: July 2019

Background: Delirium in the hospitals leads to worse outcomes for patients. There were no previous studies that characterize patients with delirium from multiple hospital locations. Objective: To describe patient characteristics screening positive for delirium and identify any correlations with hospital location and medication use. Design, Settings, Patients: Retrospective chart review of 227 hospitalized patients from a large, academic, tertiary referral, 2-campus health system. Patients were ≥18 years old and had delirium for at least ≥24 hours. Validated delirium screening tools were utilized. Measurements: Patients’ demographics, inpatient stay information, delirium episodes characteristics, drugs, and palliative and psychiatry teams’ involvement. Results: Most patients were older with a mean age of 64.1 years. The most common primary diagnoses were infection, cardiac, and pulmonary. Average length of delirium was 7.2 days (standard deviation [SD] = 8.2), and average length of stay (LOS) was 18.7 days (median = 10.5, SD = 35.1, 95% confidence interval = 14.1-23). Thirty-day readmission rate was 24.8% (65/262 hospitalizations); 12.8% of patients died in the hospital (29/227). Around one-third of hospitalizations had involvement of palliative care, palliative psychiatry, or general psychiatry team. There was a decrease in the number of medications administered 24 hours after the first recording of delirium compared to the immediate preceding 48 hours. Those hospitalizations where delirium first occurred in the intensive care unit (ICU) did have a longer LOS (average = 22.9, SD = 45.7) than those where delirium first occurred outside the ICU (average = 14.8, SD = 20.5). Patients were likely to have received an opioid within 48 hours in 51% of hospitalizations and to have received benzodiazepines in 16% of hospitalizations. Conclusion: In our study, we found that delirium significantly impacted length of delirium episode, number of episodes of delirium, length of hospital admission, and mortality. The population most sensitive to the impacts of delirium were elderly patients.
Effects of Tumor Necrosis Factor Alpha Inhibitors on Lymph Node and Ileocecal Mucosa-Associated Lymphoid Tissue Architecture in Patients With Inflammatory Bowel Disease
Authors: Duncan Virginia E , Chisholm Karen M , Pacheco M Cristina 
Published: July 2019

Background Antitumor necrosis alpha (TNFα) therapy is often used in the management of patients with inflammatory bowel disease (IBD) and may have effects on lymphoid tissue architecture and function. The goal of our study was to characterize the effects of TNFα inhibitors on mesenteric lymph node and mucosa-associated lymphoid tissue in patients with IBD. Methods We examined lymphoid tissue morphology in IBD patients treated with TNFα inhibitors compared to untreated controls. Intestinal resections from 19 patients (10 anti-TNFα treated and 9 controls) were reviewed. Immunohistochemistry for CD21, CD20, and CD3 was performed on ileocecal valve lymphoid tissue and mesenteric lymph nodes from the resection specimens to assess follicular architecture. Results Relative to control groups, TNFα-treated groups showed less preserved germinal center architecture, evidenced by lower overall semiquantitative scores for follicular architecture. Likewise, the percentage of secondary follicles to total follicles was decreased in patients treated with TNFα blockade. Conclusions Our results suggest that TNFα inhibitors may play a role in disruption of lymphoid germinal center architecture in patients with IBD. Awareness of this disrupted lymphoid morphology when examining histologic sections from patients with IBD treated with TNFα inhibitors may prevent unnecessary studies to exclude a lymphoproliferative disorder.
Feasibility and efficacy of a web-based family telehealth nutrition intervention to improve child weight status and dietary intake: A pilot randomised controlled trial
Authors: Chai Li Kheng , Collins Clare E , May Chris , Ashman Amy , Holder Carl , Brown Leanne J , Burrows Tracy L 
Published: July 2019

Introduction Innovative eHealth solutions that improve access to child weight management interventions are crucial to address the rising prevalence of childhood obesity globally. The study aimed to evaluate the feasibility and preliminary efficacy of a 12-week online telehealth nutrition intervention to improve child weight and dietary outcomes, and the impact of additional text messages (SMS) targeted to mothers and fathers. Methods Families with children aged 4 to 11 were randomised across three groups: Telehealth, Telehealth+SMS, or Waitlist control. Telehealth and Telehealth+SMS groups received two telehealth consultations delivered by a dietitian, 12 weeks access to a nutrition website and a private Facebook group. The Telehealth+SMS group received additional SMS. Feasibility was assessed through recruitment, retention, and intervention utilisation. Efficacy was assessed through changes in measured child body mass index (BMI), waist circumference and diet. Results Forty-four (96%) and 36 (78%) families attended initial and second telehealth consultations, respectively. Thirty-six families (78%) completed week 12 assessments. Child BMI and waist circumference changes from baseline to week 12 were not statistically different within or between groups. Children in Telehealth+SMS had significantly reduced percentage energy from energy-dense nutrient-poor food (95% CI −21.99 to −0.03%E; p = .038) and increased percentage energy from healthy core food (95% CI −0.21 to 21.89%E; p = .045) compared to Waitlist control. Discussion A family-focused online telehealth nutrition intervention is feasible. While the modest sample size reduced power to detect between-group changes in weight status, some improvements in child dietary intakes were identified in those receiving telehealth and SMS.
Safety and efficacy of the use of large bore intermediate suction catheters alone or in combination for the treatment of acute cerebral venous sinus thrombosis: A multicenter experience
Authors: Dandapat Sudeepta , Samaniego Edgar A , Szeder Viktor , Siddiqui Fazeel M , Duckwiler Gary R , Kiddy Ume , Guerrero Waldo R , Zheng Binbin , Hasan David , Derdeyn Colin , Ortega-Gutierrez Santiago 
Published: July 2019

Background and purpose Systemic anticoagulation is the standard treatment for cerebral venous sinus thrombosis (CVST). Several endovascular techniques have been described as salvage therapy for anticoagulation refractory CVST cases. We aim to evaluate the safety and feasibility of endovascular aspiration thrombectomy using the new generation, large bore suction catheters alone or in combination with stentriever devices for the treatment of CVST. Methods We collected data on 16 consecutive patients with CVST who received endovascular aspiration thrombectomy at three large academic centers. Second generation reperfusion catheters were used as a large bore suction catheter and advanced to the affected sinus using a coaxial technique. Suction was performed using pump suction. At times, a stentriever was used as an anchor to facilitate advancing the suction catheter and to increase thrombectomy capabilities. Results Median decade of age was the 50s and nine patients were women. Fifty percent of the patients had multiple sinuses involved. All patients received systemic anticoagulation prior to endovascular aspiration thrombectomy. The most common reason to pursue endovascular aspiration thrombectomy in CVST patients was deterioration of initial clinical status (10/16). The mean time from admission to endovascular aspiration thrombectomy was 1.5 days (range 0–6 days). Good recanalization was obtained in all patients. There were no major peri-procedural complications. Most patients were discharged to either home or a rehabilitation facility. Conclusion Endovascular aspiration treatment using large bore suction catheters for CVST is a safe and feasible approach for the treatment of anticoagulation refractory CVST. Heterogeneity of the clinical and radiological presentation requires further investigation to optimize patient selection before evaluating the efficacy of this technique in larger prospective studies.
Surgical Trends in the Treatment of Lisfranc Injuries Using the American Board of Orthopaedic Surgery (ABOS) Certification Examination Database
Authors: Raja Avais , Pena Fernando 
Published: July 2019

Background: Lisfranc joint complex injury may be managed surgically by either an open reduction internal fixation (ORIF) or primary arthrodesis (PA). Published literature advocates PA for purely ligamentous injuries, but many surgeons in actuality refrain from performing PA. The purpose of the study is to assess surgeon practices and behavior in managing Lisfranc injuries due to the influence of peer reviewed literature with the help of the American Board of Orthopaedic Surgery (ABOS) database. Methods: Data were requested from the ABOS database of cases on Lisfranc joint injury requiring either an ORIF or PA from examination year 2004 to 2017 for both part II and maintenance of certification (MOC) examinees. Cases with ICD-9 code 838.03 only were considered as primarily ligamentous and all fracture codes classified under 825 with 838.03 were considered as fracture dislocation. The number of PA and ORIF were recorded for both types of examinees and specific type of Lisfranc joint injury (primarily ligamentous and fracture dislocation). Results: A total of 2010 cases of Lisfranc joint injuries managed surgically by 1230 board-eligible orthopaedic surgeons. Open fractures (93) and non-/malunion fractures were excluded. A total of 1016 primarily ligamentous and 474 fracture dislocation cases were performed by part II examinees. Overall, 288 primarily ligamentous and 139 fracture dislocation cases were performed by MOC examinees. A total of 27 PA were performed in the primarily ligamentous and 17 were performed on fracture dislocation cases. Conclusion: ORIF is commonly performed by newly trained and senior orthopaedic surgeons. There was no change in the number of PA performed on primarily ligamentous injuries in spite of the published literature. Levels of Evidence: Not applicable