bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conclusion
Authors: Chong Nicholas 
Published: November 2024

AbstractThis book concludes with a brief consideration of two issues. First, evidence concerning Beethoven’s religious views after he completed the Missa solemnis suggests that his outlook continued to mix progressive elements inspired by the Catholic Enlightenment with an openness to some aspects of the more conservative Catholic Restoration. Second, the long-standing tendency to separate Beethoven from Catholicism, as well as the related marginalization of his religious works, emerged after the composer’s death because of two simultaneous historical processes. On the one hand, Beethoven and his music were increasingly used as symbols of a liberal German national identity that, given the political hegemony of Protestant Prussia, excluded Catholicism. On the other hand, the Catholic Church became more and more hostile toward the reformist visions of the Church associated with the Catholic Enlightenment. Beethoven’s religious works thus came to be considered too Catholic by liberals, and not Catholic enough by the Church.
Introduction
Authors: Macfarlane Kirsten 
Published: November 2024

Abstract
This book offers a fresh account of the intellectual dynamics of transatlantic puritanism using a microhistorical reconstruction of a single community of immigrants to New England. The introduction briefly introduces the nature and scope of the evidence on which this reconstruction rests, but primarily focusses on outlining the wider historiographical landscape in which it is situated. It explains how the book brings together three separate bodies of literature: the history of biblical scholarship in early modern Europe; the history of puritanism and popular religion in both Britain and North America; and the history of the book, especially the history of reading practices. By combining insights and (most importantly) methods from each of these fields, this book aspires to fulfil the early promise made by book historians that their field might be able to write ‘a social history of culture’.
Systematic review of guideline recommendations for older and frail adults with type 2 diabetes mellitus
Authors: Bolt Jennifer , Carvalho Valeria , Lin Kristine , Lee Sung Ju , Inglis Colleen 
Published: November 2024

Abstract

Background
The application of clinical practice guidelines (CPGs) across the spectrum of individuals living with diabetes can be challenging, particularly in older adults, where factors such as frailty and multimorbidity exacerbate the complexity of management.

Objective
This systematic review aimed to explore the guidance provided within diabetes CPGs for management of individuals who are older and/or frail, including recommendations for haemoglobin A1C (HbA1c) target and pharmacotherapeutic management.

Methods
A systematic search was completed in Medline and Embase to identify national or international type 2 diabetes CPGs published in the last 10 years. Data extracted included recommendations for HbA1c targets and pharmacotherapy in older and frail adults, frailty screening and deprescribing. Quality of included CPGs was appraised with the AGREE II tool.

Results
Twenty-three CPGs were included, within which older adults and frailty were discussed in 21 and 14 CPGs, respectively. Specific HbA1c targets for older and/or frail adults were provided by 15 CPGs, the majority of which suggested a strict target (&lt;7.0%–7.5%) in healthier older adults and a more relaxed target (&lt;8.0%–8.5%) in those who are frail or medically complex. Ten CPGs provided recommendations for insulin therapy and 16 provided recommendations for non-insulin antihyperglycaemic agents that were specific to older and/or frail populations, which primarily focused on minimising risk of hypoglycaemia.

Conclusion
Most diabetes CPGs recommend strict HbA1c targets in healthier older adults, with more relaxed targets in those living with frailty or medical complexity. However, significant variability exists in pharmacotherapy recommendations and there were proportionately less recommendations for individuals who are frail.
Reactive loops and normative indeterminacy
Authors: Werner Jonas 
Published: November 2024

Abstract
Temporal loops in which two agents are involved in a circle of reactive attitudes create a puzzle concerning who harms whom. I argue that this puzzle, which has been developed by Stephen Kearns in a recent paper in this journal, should be solved by accepting that the situation involves normative indeterminacy. A supervaluationist treatment of this indeterminacy allows us to maintain that the normative supervenes on the non-normative and that the involved agents are in normatively symmetric situations. It further allows to maintain that it is determinately the case that one agent wrongs the other just in case the latter does not wrong the former. I conclude by tentatively arguing that the indeterminacy involved should not be understood as semantic and that the puzzle provides us with a novel case of indeterminacy in reality.
AutoXAI4Omics: an automated explainable AI tool for omics and tabular data
Authors: Strudwick James , Gardiner Laura-Jayne , Denning-James Kate , Haiminen Niina , Evans Ashley , Kelly Jennifer , Madgwick Matthew , Utro Filippo , Seabolt Ed , Gibson Christopher , Bedi Bharat , Clayton Daniel , Howell Ciaron , Parida Laxmi , Carrieri Anna Paola 
Published: November 2024

Abstract
Machine learning (ML) methods offer opportunities for gaining insights into the intricate workings of complex biological systems, and their applications are increasingly prominent in the analysis of omics data to facilitate tasks, such as the identification of novel biomarkers and predictive modeling of phenotypes. For scientists and domain experts, leveraging user-friendly ML pipelines can be incredibly valuable, enabling them to run sophisticated, robust, and interpretable models without requiring in-depth expertise in coding or algorithmic optimization. By streamlining the process of model development and training, researchers can devote their time and energies to the critical tasks of biological interpretation and validation, thereby maximizing the scientific impact of ML-driven insights. Here, we present an entirely automated open-source explainable AI tool, AutoXAI4Omics, that performs classification and regression tasks from omics and tabular numerical data. AutoXAI4Omics accelerates scientific discovery by automating processes and decisions made by AI experts, e.g. selection of the best feature set, hyper-tuning of different ML algorithms and selection of the best ML model for a specific task and dataset. Prior to ML analysis AutoXAI4Omics incorporates feature filtering options that are tailored to specific omic data types. Moreover, the insights into the predictions that are provided by the tool through explainability analysis highlight associations between omic feature values and the targets under investigation, e.g. predicted phenotypes, facilitating the identification of novel actionable insights. AutoXAI4Omics is available at: https://github.com/IBM/AutoXAI4Omics.
From Atalanta to Angelina: Smith & Wesson feminism, white heteropatriarchy, and intimate partner violence
Authors: Nguyen Kim Hong , Voorhees Gerald 
Published: November 2024

Abstract
This article re-examines the increasingly ubiquitous media representations of ass-kicking heroines celebrated by academic and popular feminism in North America. We look at these violent white women as Smith & Wesson feminists, empowered by whiteness and their capacity for physical violence and death. As refigurations of the mythical Atalanta, their fighting power is understood as part of a feminine arsenal for managing romantic or sexual partners. This is a particular kind of white (post)feminism, prominent in the US and Canada, that may be empowering on some level, but only to the extent that women are enabled to enjoy the privileges of and assist in policing the boundaries of white heteropatriarchy. In addition to buttressing the alliance between whiteness and heteropatriarchy, it rationalizes intimate partner violence and other forms of violence, including state sanctioned violence, against women who fight back.
A novel mouse model of myositis-associated interstitial lung disease was established by using TLR9 agonist combined with muscle homogenate
Authors: Bai Ling , Zhu Jiarui , Ma Wenlan , Zhao Peipei , Li Feifei , Zhang Cen , Zhang Sigong 
Published: November 2024

Abstract
Our group previously demonstrated that NETs were involved in interstitial lung diseases (ILD) among patients with idiopathic inflammatory myopathies (IIM) and the experimental autoimmune myositis (EAM) mouse model and that NETs activated lung fibroblasts through the TLR9-miR7-Smad2 axis. This study aimed to establish a novel mouse model of myositis-associated interstitial lung disease (MAILD) by using a TLR9 agonist (ODN2395). ODN2395 and muscle homogenate were used to induce MAILD in BALB/c mice. MAILD was evaluated using histopathology, immunohistochemistry, serum NETs determination, and myositis-specific antibody profile. Furthermore, TLR9 and IRF3 were examined in a lung biopsy tissue from a dermatomyositis patient with ILD. MAILD mice developed inflammatory myopathy with positive expression of myositis-specific antibodies. ILD occurred in all mice of the MAILD group. ODN2395 at doses of 5 μg, 10 μg, or 20 μg induced ILD, with increasing severity as the dose increased, but 20 μg ODN2395 was not recommended due to non-specific damage to the lungs. ILD could occur as early as one week after immunization and was most pronounced by the fourth/fifth week. MAILD process was accompanied by NETs infiltration and TLR9 activation. TLR9 activation was demonstrated in the patient with DM-ILD. Serum levels of Cit-H3 were elevated in the MAILD group. Skeletal muscle homogenate and ODN2395 induced neutrophils to form NETs in vitro. Combined with muscle homogenate, ODN2395 induced a novel MAILD mouse model with NETs infiltration and TLR9 activation, which are similar to pathogenesis of IIM-ILD, suggesting that MAILD model could replace EAM model in IIM-ILD research.
PCBM synthesis using photoflow strategy
Authors: Sumino Shuhei , Tanaka Yuya , Murata Michihisa , Matsumoto Fukashi , Iwai Toshiyuki , Ito Takatoshi 
Published: November 2024

Abstract
In this study, photoflow synthesis was investigated to develop a more efficient synthesis of [6,6]-phenyl-C61-butyric acid methyl ester. High chemical yields were achieved via photoirradiation during heating. In addition, continuous production was confirmed using large-volume flow units, and high chemical yields and productivity were achieved.
Crustal heterogeneity and fault parametrization effects on seismic hazards assessment: southeastern margin of the Tibetan Plateau case study
Authors: Rui X , Williams C A , Stamps D S , Fang L H 
Published: November 2024

SUMMARY
Assumptions about lithospheric composition and fault discretization schemes are crucial for estimating seismic hazards. This study aims to examine the impact of these two variables in the Southeastern Margin of the Tibetan Plateau, with a specific focus on the Daliangshan mountain area. This area, located along the central segment of the Xianshuihe–Xiaojiang fault system, has been considered in the last few decades to host the highest seismic hazards in mainland China given its historical recurrence intervals of large magnitude earthquakes. Previous studies have constrained the kinematics of the region, including estimates of fault slip and accumulated moment magnitudes, assuming (1) the crust is compositionally homogeneous and isotropic and (2) the discretized fault patches (nodes) are coupling independent. In this work, we use constraint from an updated GNSS velocity solution comprised of 287 sites to test the influence of a compositionally heterogeneous crust and two fault patch (node) parametrizations to assess predicted fault slip rates and several seismic hazard quantities. The two fault node parametrizations are: (1) node depth-dependent (NDD; locking coefficients of nodes along a depth profile are dependent) and (2) node depth-independent (NDI; locking coefficients of all nodes are independent). Statistical tests (F-tests) indicate that the NDD model fits GNSS data significantly better than the NDI model even with less than ∼50 per cent of to-be-estimated parameters. We further examine the impact of lithospheric composition on regional kinematics by incorporating data from high-resolution seismic tomography. Comparisons between homogeneous and heterogeneous models for our preferred NDD fault locking parametrization scheme suggest that the material heterogeneity has minimal influence on the predicted recurrence interval estimates of large (e.g. Mw = 7) earthquakes but some influence on discerning the details of the fault coupling distribution. These results show that the crustal medium and parametrization scheme have an impact on the description of fault kinematics, which should be considered as one of the sources of uncertainty in hazard assessment.
Recording a revolution: the clerk of the parliaments and the journals of the house of lords, 1640–9
Authors: Beeton Alex 
Published: November 2024

Abstract
This article examines the creation of the journals of the house of lords during the 1640s. Making extensive use of notes kept by the clerk of the parliaments and his assistants, it argues that the journals are not objective factual records, but documents intended to project an image of the Lords as driven by consensus and tradition. In reality, the Lords were fractious and riven by faction. An investigation of the journals also has important implications for understandings of early modern record-keeping and the nascent information state, showing a deep-rooted desire in seventeenth-century England to conceal and destroy information alongside the recently explored wish to collect and use it.
The genus Paris: a fascinating resource for medicinal and botanical studies
Authors: Ye Xiao , Tao Yang , Pu Xiu-Lan , Hu Hong , Chen Jing , Tan Chun-Lin , Tan Xin , Li Sheng-Hong , Liu Yan 
Published: November 2024

Abstract
The genus Paris, comprising a series of distinctive medicinal plants, has been utilized globally for its therapeutic properties over centuries. Modern pharmacological studies have demonstrated that secondary metabolites from Paris species exhibit significant pharmacological activities, including anticancer, hemostatic, anti-inflammatory, antimicrobial and other effects. Additionally, the unique morphological traits and large genome size of Paris species have continuously captivated the interest of botanists and horticulturalists. Nonetheless, the conservation of wild Paris populations is threatened due to the lengthy reproductive cycle and overexploitation, posing considerable challenges to their development and sustainable use. This review provides a comprehensive overview of the botanical characteristics, historical medicinal uses, pharmacological effects and toxicity evaluation of secondary metabolites in Paris species. It also covers the molecular biological research conducted on the genus Paris and proposes key research questions and important directions for future solutions. We advocate for the expansion and implementation of multi-omics approaches, as well as molecular and genetic technologies recently advanced in model plant research, to intensively study Paris species. This will facilitate the comprehensive understanding of gene function and molecular mechanisms underlying specialized metabolite formation in Paris.
Global Well-Posedness for Supercritical SQG With Perturbations of Radially Symmetric Data
Authors: Bulut Aynur , Dong Hongjie 
Published: November 2024

Abstract
We study the global well-posedness of the supercritical dissipative surface quasi-geostrophic (SQG) equation, a key model in geophysical fluid dynamics. While local well-posedness is known, achieving global well-posedness for large initial data remains open. Motivated by enhanced decay in radial solutions, we aim to establish global well-posedness for small perturbations of potentially large radial data. Our main result shows that for small perturbations of radial data, the SQG equation admits a unique global solution.
The impact of overseas assignments on metabolic factors: Panasonic cohort study 23
Authors: Murano Tetsuya , Okada Hiroshi , Hamaguchi Masahide , Kurogi Kazushiro , Tatsumi Yoshihide , Murata Hiroaki , Yoshida Naoki , Ito Masato , Fukui Michiaki 
Published: November 2024

Abstract

Objectives
This study aimed to assess the effects of overseas assignments on the metabolic factors associated with lifestyle disease including body mass index, blood pressure, plasma glucose, lipid profiles, liver enzyme, and uric acid in Japanese individuals.

Methods
A retrospective cohort study was conducted using annual health examination data from employees of the Panasonic Corporation in Japan. We evaluated the differences in the changes in metabolic factors associated with lifestyle disease during the observation periods between the overseas and non-overseas assignment groups. Propensity score matching was performed to match the characteristics of the two groups. In subgroup analysis, the impact of family accompaniment and the destination on metabolic factors associated with lifestyle disease were also evaluated.

Results
The median ages of the overseas (n = 899) and non-overseas assignment groups (n = 899) were 46 (41–50) and 46 (41–50) years. The average overseas assignment duration was 4.1 ± 1.7 years. Overall, 65.4% of individuals were assigned overseas alone in the overseas assignment group. No significant differences were observed in the changes in metabolic factors associated with lifestyle disease between the overseas and non-overseas assignment groups. In subgroup analyses, the family accompaniment and the destination did not affect changes in any of metabolic factors associated with lifestyle disease during the overseas assignment.

Conclusions
In conclusion, no significant difference was observed in metabolic factors associated with lifestyle disease between the overseas and non-overseas assignment groups in Japanese employees.
Silencing c-myc gene by siRNA delivered by cationic niosomes in MCF-7 cells
Authors: Abdeljaber Shatha N , Aljabali Alaa A , Altrad Bahaa , Obeid Mohammad A 
Published: November 2024

Abstract

Objectives
Gene therapy has a strong potential to treat different cancer types cancers with high therapeutic outcomes. c-myc is believed to be responsible for more than 15% of all gene regulation and functions as a transcription factor for proteins essential for cell proliferation. This study aimed to develop niosome nanocarriers to knockdown c-myc expression using anti-c-myc short-interfering RNA (siRNA) in MCF-7 cells. Altering the activity of the c-myc proto-oncogene has been identified as an important element in minimizing cancer cell growth because anti-c-myc siRNA degrades c-myc mRNA.

Methods
Noisomes were prepared from Tween 85, cholesterol, and didodecyldimethylammonium bromide at 50:40:10 and 40:40:20 molar ratios. Anti-c-myc siRNA was loaded in the prepared niosomes and then applied on MCF-7 cells.

Key findings
Niosomes had a total positive charge formed electrostatic interactions with siRNA. Niosomes were spherical with a size range of 70–100 nm. The prepared niosomes were nontoxic to MCF-7 cells, with IC50 values of &gt;250 µg/ml for both formulations. After encapsulation of anti-c-myc siRNA, nioplexes reduced c-myc mRNA expression by more than 50% compared with the untreated cells. Empty niosomes did not affect c-myc mRNA expression levels, indicating that the effect was due to siRNA rather than the particles themselves.

Conclusions
This study provides evidence that niosomes can function as suitable carriers for siRNA delivery to knockdown the c-myc oncogene in MCF-7 cells, thus reducing cancer cell growth.
Contrasting bivalve body-size distributions between Northern and Southern Hemispheres
Authors: Doyle Amanda 
Published: November 2024

ABSTRACT
Despite similarly frigid climates and low diversity compared to the tropics, the Northern and Southern Hemisphere polar regions—and the high latitudes of the Northern and Southern Hemisphere at large—have different histories, and their biotas differ in a number of ways, but these biotic contrasts remain understudied. In this study, I tested whether the body sizes of Northern and Southern Hemisphere extratropical bivalve faunas differ from each other. The Southern Hemisphere polar bivalve fauna has a significantly smaller median body size than the Northern Hemisphere polar region, and this difference remains whether shared families, shared genera or the whole fauna was compared. There were also significant, pervasive contrasts in body size between the Northern and Southern Hemisphere throughout the extratropics for the whole bivalve fauna and largely for the five major bivalve clades examined (Protobranchia, Pteriomorphia, Archiheterodonta, Anomalodesmata and Imparidentia), and these contrasts largely remained even when only endemics were compared.
PanKB: An interactive microbial pangenome knowledgebase for research, biotechnological innovation, and knowledge mining
Authors: Sun Binhuan , Pashkova Liubov , Pieters Pascal Aldo , Harke Archana Sanjay , Mohite Omkar Satyavan , Santos Alberto , Zielinski Daniel C , Palsson Bernhard O , Phaneuf Patrick Victor 
Published: November 2024

Abstract
The exponential growth of microbial genome data presents unprecedented opportunities for unlocking the potential of microorganisms. The burgeoning field of pangenomics offers a framework for extracting insights from this big biological data. Recent advances in microbial pangenomic research have generated substantial data and literature, yielding valuable knowledge across diverse microbial species. PanKB (pankb.org), a knowledgebase designed for microbial pangenomics research and biotechnological applications, was built to capitalize on this wealth of information. PanKB currently includes 51 pangenomes from 8 industrially relevant microbial families, comprising 8402 genomes, over 500 000 genes and over 7M mutations. To describe this data, PanKB implements four main components: (1) Interactive pangenomic analytics to facilitate exploration, intuition, and potential discoveries; (2) Alleleomic analytics, a pangenomic-scale analysis of variants, providing insights into intra-species sequence variation and potential mutations for applications; (3) A global search function enabling broad and deep investigations across pangenomes to power research and bioengineering workflows; (4) A bibliome of 833 open-access pangenomic papers and an interface with an LLM that can answer in-depth questions using its knowledge. PanKB empowers researchers and bioengineers to harness the potential of microbial pangenomics and serves as a valuable resource bridging the gap between pangenomic data and practical applications.