bluuebunny/crossref_metadata_2025_split huggingface dataset:
QUANTITATIVE RELATIONSHIP OF ELECTRONIC STRUCTURE AND INHIBITION ACTIVITY OF CURCUMIN ANALOGS ON ETHOXYRESORUFIN o-DEALKYLATION (EROD) REACTION
Authors: Pranowo Harno Dwi , Tahir Iqmal , Widiatmoko Ajidarma 
Published: January 2019

Electronic structure and inhibition activity relationship study of curcumin analogs has been established for 29 curcumin analogs on Ethoxyresorufin O-Dealkylation (EROD) reaction using atomic net charge descriptor based on AM1 semiempirical calculations. The QSAR (Quantitative Structure and Activities Relationships) equation model was determined by statistical parameter from multiple regression analysis and leave-one-out cross validation method. The best QSAR equation was described: Keywords: curcumin, QSAR, descriptor, atomic net charge, semiempirical methods.
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF BIXIN PIGMENT FROM ANNATTO (Bixa orellana L.) SEEDS
Authors: Kurniawati Pipin T. , Soetjipto H. , Limantara Leenawati 
Published: January 2019

Research on Bixa orellana L. have been done to isolate, identify and determine bixin percentage, the antioxidant and antibacterial activities of bixin from B. orellana seed. Isolation and identification of bixin was done by thin layer chromatography (TLC), column chromatography, chemical test of bixin and UV-Vis double beam spectroscopy. Percentage of bixin was calculated by JECFA method, the antioxidant activity was determined by DPPH (1-1 diphynilpicrylhidrazil) method while antibacterial activity was analyzed by the use of agar diffusion method. Thin layer chromatography (TLC) for the crude extract contained 5 spot, where spot 5th was bixin. Bixa orellana has 75±3% of bixin. Antioxidant activity of bixin had IC50 548.5±20.0 ppm. Whereas the antibacterial activity of bixin against the Escherichia coli and Staphylococus aureus could be classified as weak inhibition category at 500-750 μg and medium inhibition category at 1500 μg. Keywords: Bixa orellana L., bixin, antioxidant, antibacteria
IDENTIFICATION OF THE ISOLATED COMPOUNDS FROM Zingiber amaricans BL. RHIZOME
Authors: Riyanto Sugeng 
Published: January 2019

Five extracts were obtained from extraction of rhizomes of Zingiber amaricans. Hexane, dichloromethane and methanol extracts were obtained by maceration, while dichloromethane and acetone extracts the resulted of soxhlet extraction. By column chromatography technique 2,6,9-humulantrien-9-one (zerumbone) was isolated as the major constituent of the hexane, dichloromethane and methanol extracts. The minor constituents were phytosterol mixtures isolated from hexane and dichloromethane extracts. The mixtures consisted cholesterol, campesterol, stigmasterol and b-sitosterol. The structure elucidations of zerumbone was confirmed by spectroscopic method, whereas the phytosterol mixtures was identified by gas chromatography-mass. Keywords: zerumbone, phytosterol, zingiber amaricans, spectroscopy
MONTE CARLO SIMULATIONS OF Co (II) IN WATER INCLUDING THREE-BODY CORRECTION
Authors: Kusumawardani Cahyorini , Pranowo Harno Dwi , Partana Crys Fajar , Mudasir Mudasir 
Published: January 2019

In order to describe the cobalt-water interaction correctly, a new ab initio potential was developed consisting of pair interaction terms as well as three-body contributions. Within this approach, it was possible to correct for the well-known failures of pair potentials in describing solvation phenomena of such ions. A first-shell coordination number of 6 in agreement with experimental data were obtained from Monte Carlo simulations of a single cobalt (II) ion in water. The structure of hydrated ion is discussed in terms of radial density functions and coordination number, energy and angular distributions. Keywords: MC Simulations, cobalt(II), hydration, three-body correction
BALANOCARPOL AND AMPELOPSIN H, TWO OLIGORESVERATROLS FROM STEM BARK OF <i>Hopea odorata</i> (DIPTEROCARPACEAE)
Authors: Atun Sri , Aznam Nurfina , Arianingrum Retno , Niwa Masatake 
Published: January 2019

Two oligoresveratrol, namely balanocarpol (2) and ampelopsin H (3) had been isolated from the steam bark of Hopea odorata (Dipterocarpaceae). The structures of these compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR 1D and 2D). The activity of these compounds was evaluated against the 2-deoxyribose degradation induced by the hydroxyl radical generated via a Fenton-type reaction. The result showed that activity each compounds as radical hydroxyl scavenger of balanocarpol, and ampelopsin H with an IC50 1802.3 and 4840.0 μg/mL, respectively. Each compound showed low activity. Vitamin C (IC50 83.9 μg/mL) and butylated hydroxyl toluene (1328.0 μg/mL) were used as positif controls. These results suggest that oligoresveratrols from stem bark of H. odorata may be useful as potential sources of natural antioxidants. Keywords: balanocarpol, ampelopsin H, antioxidant, Dipterocarpaceae
THE COMPOSITION AND THE CONTENT OF PIGMENTS FROM SOME DYEING PLANT FOR IKAT WEAVING IN TIMORRESE REGENCY, EAST NUSA TENGGARA
Authors: Ati Neltji Herlina , Rahayu Puji , Notosoedarmo Soenarto , Limantara Leenawaty 
Published: January 2019

Ikat weaving is one of traditional-home industry using plant pigments as a dye which have not been known for their pigments composition. So, the research was carried out to know the composition and the content of pigments in young leaf teak, noni root, turmeric tuber, casuarine bark and betel-nut root. The result showed that pigment composition in young leaf teak consisted of β-carotene, pheophytine, phelargonydine 3-glucosyde, phelargonydine 3,7-diglucosyde, chlorophyllide and two other pigments that have not been identified. Most of the pigments composition in betel-nut root have not been identified, but one of them was condensed tanin. Noni root had pigment composition which consisted of hydrolised tanin, flavonoid and morindon. Pigment composition in turmeric tuber were curcumin, demethoxy curcumin and bis-demethoxy curcumin. Whereas casuarine bark had pigment composition which consisted of delphynidine, cyanydine and phelargonydine. The highest pigment concentration in young leaf teak, betel-nut root, noni root, tumeric tuber and casuarine bark was pheophytine, tanin condensation, morindon, curcumin and cyanidine, respectively. Keywords: ikat weaving, chlorophyll, carotenoid, anthocyanin
ELECTROPOLYMERISATION AND CHARACTERISATION OF DOPED-POLYPYRROLE AS HUMIDITY SENSOR
Authors: Siswoyo Siswoyo , Nugroho Trio F. , Zulfikar Zulfikar , Subekti Agus 
Published: January 2019

A new type of sensing materials for humidity measurement has been developed based on conducting polymer polypyrrole synthesised from pyrrole by adding some dopant compounds, bromide and chloride, it is prepared by potentiodynamic-electropolymerisation technique. Variation of dopant types and concentration has been carried out in order to investigate the effect of this variation to the change of polymeric conductivity when interacting with water vapour. Polypyrrole-Cl (Ppy-Cl) and polypyrrole-Br (Ppy-Br) exhibit a good principal characteristic as sensor candidate namely responding proportionally to humidly variation ranging 30% - 90% relative humidity. Characterisation test for the sensor candidates has been carried out for evaluating their linearity respond toward humidity, their stability in certain period and their reproducibility in some tests. The results show that Ppy-Cl and Ppy-Br showing good linearity respond with R value in a range of 0.95 - 0.99. Their reproducibility and sensitivity were relatively good, however their respond stability were only last in few days. The stability probably is related to the stability of resulted polymeric structure that very affected by synthesis process and dopant used. It is necessary to extend the use of other dopant materials and changing the synthesis process in order to improve sensor stability. In other hand it is also necessary to characterise other performance characteristic of the sensor namely response time, and interference effect of some volatile chemicals and other gases. Keywords: polypyrrole, potentiodynamic, electropolymerisation, humidity sensor and conducting polymer
THE INFLUENCES OF Fe(III) ION and Fe(OH)<sub>3</sub> COLLOID ON THE PHOTODEGRADATION of <i>p</i>-CHLOROPHENOL CATALYZED BY TiO<sub>2</sub>
Authors: Wahyuni Endang Tri , Mudasir Mudasir , Hadipranoto Ngatidjo 
Published: January 2019

The influences of ionic Fe(III) and colloidal Fe(OH)3 on the effectiveness of p-chlorophenol photodegradation catalyzed by TiO2 has been studied. Photodegradation was carried out in a batch system by irradiating a suspension of TiO2, p-chlorophenol, and Fe(III) as ionic or colloidal forms, using UV lamp for a period of time accompanied by magnetic stirring. Concentration of photodegraded p-chlorophenol was calculated by subtracting the initial concentration with that of undegraded p-chlorophenol. Concentration of undegraded p-chlorophenol was determined by gas chromatography. In this study, TiO2 mass and the photodegradation time were optimized. The influences of concentration of Fe(III) solution, mass of Fe(OH)3, and pH of the solution have also been systematically studied. The research results showed that the presence of Fe(III) ions improved the effectiveness of photocatalytical degradation of p-chlorophenol, which was proportional to the concentrations of Fe(III) ion. In contrast, the increasing mass of Fe(OH)3 led to a decrease in the degree of p-chlorophenol photodegradation. Furthermore, it was observed that increasing pH of the solution resulted in a decrease in the photodegradation of p-chlorophenol. This phenomena may be due to the different species of TiO2 available at the surface of photocatalyst and of ionic Fe(III) and colloidal Fe(OH)3 in the solution resulted from the pH alteration. The highest photodegradation degree, ca. 80 % was obtained when 20 mg of TiO2 was applied in the photodegradation of 50 mL of 100 ppm p-chlorophenol solution in the presence of 100 ppm Fe3+ irradiated by UV-light for 25 hours. Keywords: p-chlorophenol photodegradation, TiO2, Fe(III) species
GROWTH RATE DISTRIBUTION OF BORAX SINGLE CRYSTALS ON THE (001) FACE UNDER VARIOUS FLOW RATES
Authors: Suharso Suharso 
Published: January 2019

The growth rates of borax single crystals from aqueous solutions at various flow rates in the (001) direction were measured using in situ cell method. From the growth rate data obtained, the growth rate distribution of borax crystals was investigated using Minitab Software and SPSS Software at relative supersaturation of 0807 and temperature of 25 °C. The result shows that normal, gamma, and log-normal distribution give a reasonably good fit to GRD. However, there is no correlation between growth rate distribution and flow rate of solution. Keywords: growth rate dispersion (GRD), borax, flow rate
RADIATION GRAFTING OF STYRENE ONTO PTFE FILM
Authors: Yohan Yohan , Nur Rifaid M. , Hendrajaya Lilik , Siradj E. S. 
Published: January 2019

Radiation grafting of styrene monomer onto poly(tetrafluoroethylene) (PTFE) film has been investigated. This research is emphasized on the conditioning of PTFE film. It was irradiated by -ray radiation at various irradiation dose from 2.5 - 12.5 kGy with dose rate 1.9 kGy/hour. Irradiated copolymer was then grafted by styrene monomer under various conditions. The results showed that degree of grafting increased by increasing irradiation dose, solvent concentration, temperature and time of grafting. The optimum condition of radiation grafting relatively was obtained at irradiation dose of 10 kGy, 2-propanol solvent, styrene concentration of 40 volume%, temperature and time of grafting of 70 oC and 6 hours each. Keywords: Radiation grafting, PTFE, Fuel cell
PHOTODEGRADATION OF ALIZARIN S DYE USING TiO<sub>2</sub>-ZEOLITE AND UV RADIATION
Authors: Wijaya Karna , Sugiharto Eko , Fatimah Is , Tahir Iqmal , Rudatiningsih Rudatiningsih 
Published: January 2019

An investigation of Alizarin S photodegradation using TiO2-zeolite and UV radiation was performed. TiO2-zeolite was prepared by dispersing oligocations of titanium into suspension of zeolite. The suspension was stirred and then filtered to separate the solid phase from the filtrate. the solid phase was calcined by microwave oven at 800 Watt for 5 minutes to convert the oligocations into its oxide forms. The calcined product and unmodified zeolite were characterized using x-ray diffractometry, FT-IR spectrophotometry, X-ray fluorescence and gas sorption analysis methods to determine their physicochemical properties. Photocatalytic activity of TiO2-zeolite was tested on Alizarin S solution using following method: 50 mg of zeolite was dispersed into 25 mL of 10-4 M Alizarin S. The dispersion was irradiated using 365 nm UV light at room temperature on various irradiation times, i.e. 10, 20, 30, 40 and 60 minutes. At certain irradiation time, the dispersion was filtered and the filtrate was then analyzed its concentration using UV-Vis spectrophotometry method. Characterization results exhibited that the formation of TiO2 on internal as well as external surfaces of zeolite could not be detected with x-ray diffractometry and FT-IR spectrophotometry, however determination of titanium using x-ray fluorescence analysis on the calcined product showed that the concentration of titanium was much higher than zeolite (0.22% on zeolite and 12.08% on TiO2-zeolite). Gas sorption analysis result indicated that the the calcination resulted in the increase of specific surface area (16,31 m2/g on zeolite and 100.96 m2/g on TiO2-zeolite) as well as total pore volume of calcined product (13.34 mL/Å/g on zeolite and 57.54 mL/Å/g on TiO2-zeolite). The result of photocatalytic activitiy study showed that ca 99 % of Alizarin S was degraded by TiO2-zeolite after UV irradiation for 60 min. Keywords: TiO2-zeolite, photocatalytic, Alizarin S.
BIOACCUMULATION DYNAMICS OF HEAVY METALS IN <sub>Oreochromis nilotycus</sub>: PREDICTED THROUGH A BIOACCUMULATION MODEL CONSTRUCTED BASED ON BIOTIC LIGAND MODEL (BLM)
Authors: Noegrohati Sri 
Published: January 2019

In estuarine ecosystem, sediments are not only functioning as heavy metal scavenger, but also as one of potential sources for heavy metals to the ecosystem. Due the capability of aquatic organisms to accumulate heavy metals, there is possibility of heavy metals to exert their toxic effect towards the organisms and other organisms positioned in higher trophic level, such as fish, and further to human beings. To understand the different processes of heavy metal bioaccumulation in a dynamic manner, a bioaccumulation model is required. Since bioaccumulation starts with the uptake of chemical across a biological membrane, the bioaccumulation model was constructed based on Biotic Ligand Model (BLM). The input for the model was determined from laboratory scale simulated estuarine ecosystem of sediment-brackish water (seawater:Aquaâ 1:1) for determining the heavy metal fractions in sediments; simulated Oreochromis nilotycus - brackish water (fish-water) ecosystem for determining the rate constants; simulated fish-water-sediment ecosystem for evaluating the closeness between model-predicted and measured concentration, routes and distribution within specific internal organs. From these bioaccumulation studies, it was confirmed that the internalization of metals into the cells of gills and internal epithelias follows similar mechanisms, and governed mostly by the waterborne or hydrophilic heavy metals. The level of hydrophilic heavy metals are determined by desorption equilibrium coefficients, 1/KD, and influenced by salinity. Physiologically, the essential Cu and Zn body burden in O. nilotycus are tightly homeostasis regulated, shown as decreasing uptake efficiency factor, EW, at higher exposure concentrations, while non essential Cd and Hg were less or not regulated. From the distribution within specific internal organs, it was revealed that carcass was more relevant in describing the bioaccumulation condition than liver. It is clear that every heavy metal has its own bioaccumulation dynamics, depend to the metal studied and environmental conditions, however the obtained parameters are applicable to bioaccumulation of Cd and Hg in natural estuarine ecosystem of Segara Anakan, Central Java. Keywords: heavy metal, estuarine, bioaccumulation, model, dynamics
NON PHENOLIC COMPOUNDS ISOLATED FROM THE LEAVES OF FERN <i>Chingia sakayensis</i> (Zeiller) Holtt
Authors: Suyatno Suyatno , Zaini Noor Cholies , Indrayanto Gunawan , Tori Motoo 
Published: January 2019

Two non phenolic compounds namely a wax ester hexacosyl hexadecanoic and a steroid -sitosterol were isolated from the n-hexane extract of the fern Chingia sakayensis (Zeiller) Holtt's leaves. Their structures were elucidated on the basis of the spectrometric evidences (UV, IR, 1H-NMR, 13C-NMR, EIMS and HR-CIMS ). Keywords: Chingia sakayensis, wax ester, steroid, hexacosyl hexadecanoic, -sitosterol
SYNTHESIS AND PHYSICOCHEMISTRY PROPERTIES PREDICTION OF A NEW POTENTIAL ANTI-INFLAMMATORY AGENT: DIACETYL PENTAGAMAVUNON-1
Authors: Margono Supardjan A. , Pudjono Pudjono , Prasojo St. Layli , Julianus Jeffry , Istyastono Enade Perdana 
Published: January 2019

Synthesis and physicochemistry properties prediction of a potential anti-inflammatory agent, diacetyl pentagamavunon-1 (diacetyl PGV-1), has been done. The synthesis was using pentagamavunon-1 (PGV-1) (2,87x10-3 mole) and anhydride acetic acid (26x10-3 mole; 37x10-3 mole; 49x10-3 mole) as starting materials and NaOH ethanolic as a catalyst. The AM1 semiempirical quantum-chemical calculations using the computational chemistry approach was used to predict and compare the physicochemisty properties of diacetyl PGV-1 to PGV-1. Odorless, light-yellow powder has been obtained. The powder was 0.8512-0.9602 g (2.02 x10-3 - 2.22x10-3 mole; 70.4-77.4%) and the purity of the powder was 92.4%. The purity of the product has been examined by high performance liquid chromatography (HPLC), while the structure elucidation has been done using IR (Infra Red), 1H-NMR (Nuclear Magnetic Resonance) and MS (Mass Spectroscopy). The physicochemisty properties prediction showed that diacetyl PGV-1 was more hydrophobic than PGV-1. Keywords: Anti-inflammatory, PGV-1, diacetyl PGV-1, AM1
SYNTHESIS OF 4-(3,4-DIMETOXY-PHENYL)-3-BUTENE-2-ON AND ACTIVITY IT’S TEST AS A FRUIT FLIES ATRACTANT
Authors: Pranowo Deni , Suputa Suputa , Wahyuningsih Tutik Dwi 
Published: January 2019

4-(3,4-dimethoxyphenyl)-3-buten-2-on has been synthesized from veratraldehyde and acetone via aldol condensation. The reaction was performed at room temperature under basic condition for 24 hours to give brown solid of product (m.p 64-6 5oC) in 73.7% yield. Veratraldehyde itself was produced from alkylation of vanillin by the use of dimethylsulfate. The structure of the products was analyzed by FTIR, 1H NMR and GC-MS. Activity test of 4-(3,4-dimethoxyphenyl)-3-buten-2-on as an attractant was carried out in Sleman, Bantul and Kulon Progo with methyl eugenol as a reference. The result showed that 4-(3,4-dimethoxyphenyl)-3-buten-2-on was inactive compound as a fruit flies attractant and some of fruit flies, i.e. Bactrocera papayae, B. carambolae, B. umbrosa and B. abdolonginqua was found on the test area. Keywords: 4-(3,4-dimetoxy-phenyl)-3-butene-2-on, Bactrocera spp., attractant
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS (QSAR) OF VINCADIFFORMINE ANALOGUES AS THE ANTIPLASMODIAL COMPOUNDS OF THE CHLOROQUINOSENSIBLE STRAIN
Authors: Tahir Iqmal , Mudasir Mudasir , Yulistia Irza , Mustofa Mustofa 
Published: January 2019

Quantitative Structure-Activity Relationship (QSAR) analysis of vincadifformine analogs as an antimalarial drug has been conducted using atomic net charges (q), moment dipole (), LUMO (Lowest Unoccupied Molecular Orbital) and HOMO (Highest Occupied Molecular Orbital) energies, molecular mass (m) as well as surface area (A) as the predictors to their activity. Data of predictors are obtained from computational chemistry method using semi-empirical molecular orbital AM1 calculation. Antimalarial activities were taken as the activity of the drugs against chloroquine-sensitive Plasmodium falciparum (Nigerian Cell) strain and were presented as the value of ln(1/IC50) where IC50 is an effective concentration inhibiting 50% of the parasite growth. The best QSAR model has been determined by multiple linier regression analysis giving QSAR equation: Log (1/IC50) = 9.602.qC1 -17.012.qC2 +6.084.qC3 -19.758.qC5 -6.517.qC6 +2.746.qC7 -6.795.qN +6.59.qC8 -0.190. -0.974.ELUMO +0.515.EHOMO -0.274. +0.029.A -1.673	(n = 16; r = 0.995; SD = 0.099; F = 2.682) Keywords: QSAR analysis, antimalaria, vincadifformine.
DETERMINATION OF VANILLIN IN VANILLA (Vanilla planifolia Andrews) FROM LAMPUNG INDONESIA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Sujalmi Siti , Suharso Suharso , Supriyanto R , Buchari Buchari 
Published: January 2019

This paper describes a reverse-phase high performance liquid chromatographic (HPLC) method for the separation, identification and quantification of vanillin in ethanolic extracts of cured vanilla. The fresh green beans were cured by three methods: scalding in hot water, drying in the oven, and drying in the sun. Two treatments for the cured beans before extraction, there were cutting cured vanilla about 2.5 cm and not cutting. The extraction was with Soxhletation and percolation method in 99.9 % ethanol. The vanillin was separated on C18 column using a mobile phase gradient of methanol - acidified water (10-90), detection at 280 nm. The HPLC technique allows a more accurate means of determining the vanillin content of vanilla than the spectrophotometric method . Keywords: Vanilla planifolia Andrews, Vanillin, HPLC
EFFECT OF ACID CONCENTRATION ON CHARACTERS OF SILICA GEL SYNTHESIZED FROM SODIUM SILICATE
Authors: Nuryono Nuryono , Narsito Narsito 
Published: January 2019

In this research, synthesis and characterization of silica gel from sodium silicate through sol-gel process using H2SO4, HCl, and citric acid have been investigated. Synthesis was carried out by mixing and stirring 20 mL of H2SO4, HCl or citric acid at certain concentration with 50 mL of sodium silicate solution (Na2O 0.17 M and SiO2 0.61 M) for one hour and let to form gel. The gel was washed with distillated water, and dried in an oven at 100 oC. Characterization of silica gel was carried out by determination of acidity, water adsorption capacity, and water content. Identification of functional group and structure were identified using x-ray diffractometer (XRD) and infrared (IR) spectrophotometer, respectively. Results showed that at a range of investigated concentration (0.6 - 3.0 M) the increase of concentration, formation of gel with H2SO4 tended to be faster, but with HCl and citric acid to be slower. The increase of acid concentration caused water content, water adsorption capacity, and acidity of the silica gel resulted with HCl and citric acid tended to be increased, increased, and increased, but with H2SO4 to be decreased, increased, and decreased, respectively. Based on the IR spectra and XRD data, it could concluded that the synthetic silica gels contained silanol (Si-OH) and siloxane (Si-O-Si) and were amorphous, showing similar pattern to kieselgel G 60 produced by Merck. Keywords: silica gel, adsorption capacity, sodium silicate, acidity
STUDY OF REACTION OF TRANS-[Pt(<sup>15</sup>NH<sub>3</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]<sup>2+</sup> WITH N-ACETYL-L-CYSTEINE
Authors: Hadi Sutopo , Appleton Trevor G 
Published: January 2019

A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and N-acetyl-L-cysteine (H3accys) was undertaken to confirm the identity of the products formed. In alkaline solution, the platinum products observed were mononuclear species, while in acidic solution, the oligomeric products were obtained. The mass spectrometry of the reaction in alkaline solution showed a sulfur-bridged dinuclear platinum(II) species, trans-[{Pt(H2accys-S)2(15NH3)2}2((-H2accys-S)]+ giving m/z 948 and the lost of two ammines was observed. Keywords: thiolate, oligomers, 2D NMR, mass spectrometry