bluuebunny/crossref_metadata_2025_split huggingface dataset:
The missing light of theHubbleUltra Deep Field
Authors: Borlaff Alejandro , Trujillo Ignacio , Román Javier , Beckman John E. , Eliche-Moral M. Carmen , Infante-Sáinz Raúl , Lumbreras-Calle Alejandro , de Almagro Rodrigo Takuro Sato Martín , Gómez-Guijarro Carlos , Cebrián María , Dorta Antonio , Cardiel Nicolás , Akhlaghi Mohammad , Martínez-Lombilla Cristina 
Published: December 2018

Context. TheHubbleUltra Deep field (HUDF) is the deepest region ever observed with theHubbleSpace Telescope. With the main objective of unveiling the nature of galaxies up toz ∼ 7 − 8, the observing and reduction strategy have focused on the properties of small and unresolved objects, rather than the outskirts of the largest objects, which are usually over-subtracted.Aims. We aim to create a new set of WFC3 IR mosaics of the HUDF using novel techniques to preserve the properties of the low surface brightness regions.Methods. We createdABYSS: a pipeline that optimises the estimate and modelling of low-level systematic effects to obtain a robust background subtraction. We have improved four key points in the reduction: 1) creation of new absolute sky flat fields, 2) extended persistence models, 3) dedicated sky background subtraction and 4) robust co-adding.Results. The new mosaics successfully recover the low surface brightness structure removed on the previous HUDF published reductions. The amount of light recovered with a mean surface brightness dimmer thanμ¯= 26 mag arcsec−2is equivalent to am = 19 mag source when compared to the XDF and am = 20 mag compared to the HUDF12.Conclusions. We present a set of techniques to reduce ultra-deep images (μ >  32.5 mag arcsec−2, 3σin 10 × 10 arcsec boxes), that successfully allow us to detect the low surface brightness structure of extended sources on ultra deep surveys. The developed procedures are applicable to HST, JWST, EUCLID and many other space and ground-based observatories.
Study Of Domestic E-Waste Management in Sungguminasa City, Gowa Regency, South Sulawesi Province, Indonesia
Authors: Irwan Ridwan Rahim , Rusdi Usman Latif , Syahiq Mahzuz Umar 
Published: December 2018

E-waste is the impact resulting from the massive use of electronic goods in the information technology era. The increasing use of electronic goods resulted in increasing electronic waste.
This study aims to calculate the potential of generation and characteristics of e-waste, processing methods and potential economic value of electronic e-waste recycling in Sungguminasa City, Gowa Regency, South Sulawesi Province, Indonesia. The study was conducted in 14 sub-districts in Somba Opu district, the largest population district in Sungguminasa City with population of 157,448 people or about 1.67% of the population of South Sulawesi Province.
The research method is conducted by analyzing the data obtained through: survey, observation and interview to the head of household in Somba Opu District, household divided in 3 groups by monthly income level (high, medium and low) and obtained: e-waste characteristics, waste generation potential, processing method and potential economic value of recycled e- waste.
The analysis results of 37 types of electronic goods, 3 types of electronic goods with the largest percentage are: televisions, refrigerators, personal computers, namely: 26%, and 17%, 14% or respectively: 150, 98, and 80 units/year. The potential of e-waste generation in Somba Opu District: 801,8 ton/year. The traditional method of e-waste processing is “converted function” by 55% and then “repaired” by 19% and “stored” by 17%, while the least applied e-waste method is “discarded” with a percentage of 9%. The results of the economic potential analysis of e-waste recycling of the 3 largest electronic goods are: refrigerator US$ 32,439, computer US$ 45,994 and television US$ 76,254 (US$ 1,00 = IDR 14,000)
Schweigepflicht: Worauf Heilpraktiker achten sollten
Authors: Gosemann Laura 
Published: December 2018

SummaryHeilpraktiker und Ärzte unterliegen der Schweigepflicht, jedoch auf Grundlage unterschiedlicher Gesetze: der Heilpraktiker gemäβ BGB und der Arzt gemäβ dem StGB. Das Patientengeheimnis gilt auch gegenüber dem Finanzamt. Im Gegensatz zum Arzt hat der Heilpraktiker kein Zeugnisverweigerungsrecht.
Ich sehe… was?
Authors: Herzog Michael , Sengebusch Jürgen 
Published: December 2018

SummaryDiese Hautreaktionen treten meist schnell und heftig auf, und zwar aufgrund der verschiedensten Ursachen. Sie können sehr unterschiedlich und teilweise bedrohlich verlaufen. Es ist wichtig, den Hergang einschätzen zu können, um angemessen zu handeln.
Arzneimittelzulassung von Radiopharmaka im klinischen Rahmen
Authors: Schildan Andreas , Hirschfeld Jürgen , Patt Marianne , Sabri Osama 
Published: December 2018

ZusammenfassungGrundlage für das Inverkehrbringen von Radiopharmaka ist die arzneimittelrechtliche Zulassung des betreffenden Arzneimittels. Bei der Arzneimittelmittelzulassung handelt es sich um eine behördliche Genehmigung, deren Zweck die Gefahrenabwehr durch unsichere oder unwirksame Arzneimittel ist und die nur für genau bezeichnete Indikationen gilt, bei denen das positive Nutzen-Risiko-Verhältnis des Arzneimittels erwiesen ist.Neben rein nationalen Zulassungsverfahren existieren auch verschiedene Zulassungsverfahren auf europäischer Ebene, die zur Verkehrsfähigkeit der Arzneimittel in einem, mehreren oder allen Mitgliedstaaten der EU bzw. des EWR führen. Die erteilten Zulassungen gelten nicht unbegrenzt, sondern unterliegen z. B. der Pflicht zur Verlängerung durch den Genehmigungsinhaber. Änderungen in Qualität, Wirksamkeit und Unbedenklichkeit des Arzneimittels bedingen eine fortwährende Pflege der Antragsunterlagen im Rahmen von Änderungsanzeigen, die bestimmten formalen und inhaltlichen Voraussetzungen genügen müssen. Sind diese und andere Voraussetzungen nicht erfüllt oder treten Fristversäumnisse auf, kann eine Zulassung auch erlöschen.
Alles im Lot?
Authors: Strzemsky Simon 
Published: December 2018

SummaryDas CMS umfasst den Kopf, Unterkiefer und alle Strukturen, die auf diesen Komplex einwirken. Treten in auf- oder absteigenden Verkettungen myofunktionelle Störungen auf, kann es zur CMD mit Symptomen im ganzen Organismus kommen. Mithilfe verschiedener Tests lässt sich ermitteln, welche Strukturen des CMS ursächlich beteiligt sind.
Prevalence of Sonographic Markers of Placenta Accreta Spectrum in Low-Risk Pregnancies
Authors: Philips Jennifer , Gurganus Margot , DeShields Sarah , Cunningham Tina , Sinkovskaya Elena , Kanaan Camille , Porche Lea , Abuhamad Alfred 
Published: December 2018

Objective This study was aimed to evaluate the prevalence of sonographic markers for placenta accreta spectrum (PAS) in pregnancies at low-risk for PAS.
Study Design Pregnant women at low-risk for PAS presenting for routine second trimester ultrasound who enrolled in the study were evaluated prospectively for sonographic markers of PAS during two ultrasounds at 18 to 24 and 28 to 34 weeks. Frequencies of PAS markers were compared between the second and third trimester and between those with and without prior cesarean deliveries (CD).
Results Overall, 174 women were included. Several markers were seen frequently in the second trimester: vascular cervical invasion (57%), lacunae (46%), subplacental hypervascularity (37%), and irregularity of the posterior bladder wall (37%). Other markers were seen infrequently or not at all: loss of the retroplacental clear zone, uterovesical interface < 1 mm, bridging vessels, placental bulge or focal exophytic mass. Frequencies of markers did not differ between women with and without prior CD. Lacunae were larger and more numerous in the third trimester. Two or more PAS markers were observed in 98% of second trimester ultrasounds.
Conclusion Several PAS sonographic markers occur commonly in low-risk pregnancies. In the absence of risk factors, the independent predictive value of these markers is questionable.
Muscle-Specific Kinase Autoimmune Myasthenia Gravis: Report of a Pediatric Case and Literature Review
Authors: Benrhouma Hanene , Klaa Hedia , Ben Aoun Rania , Rouissi Aida , Ben Ahmed Melika , Kraoua Ichraf , Ben Youssef-Turki Ilhem , Ben Younes Thouraya 
Published: December 2018

AbstractMyasthenia gravis (MG) with antibodies to the muscle-specific tyrosine kinase (MuSK-MG) receptor is a rare entity. It represents 5 to 8% of all MG patients. Few pediatric cases were reported. Clinical presentation is often atypical. It is characterized by predominant involvement of cranial, bulbar, and axial muscles and early respiratory crises. Myokymia and fasciculation are suggestive of MuSK-MG. The clinical course of patients with MuSK-MG is worse than other types of MG. Responses to standard therapies are variable. We report clinical, neurophysiological, serological, and outcome profile of a Tunisian child with MuSK-MG.
Health Care Professionals' Perceptions about Sensory-Based Interventions in the NICU
Authors: Pineda Roberta , Roussin Jessica , Heiny Elizabeth , Smith Joan 
Published: December 2018

Objective The main objective of this article is to define perceptions of health care professionals regarding current use of sensory-based interventions in the neonatal intensive care unit (NICU).
Study Design A multidisciplinary group of NICU health care professionals (n = 108) defined the types of sensory-based interventions used in their NICU, the postmenstrual age (PMA) sensory-based interventions are administered, conditions under which sensory-based interventions are used, and personnel who administer sensory-based interventions.
Results The most commonly reported tactile intervention was infant holding (88% of respondents), the most common auditory intervention was recorded music/singing (69% of respondents), the most common kinesthetic intervention was occupational and physical therapy (85% of respondents), and the most common vestibular intervention was infant swings (86% of respondents). Tactile interventions were initiated most often at 24 to 26 weeks PMA (74% of respondents), auditory interventions at 30 to 32 weeks (60% of respondents), kinesthetic interventions at 30 to 32 weeks (76% of respondents), vestibular interventions at 33 to 34 weeks (86% of respondents), and visual interventions at 32 to 36 weeks (72% of respondents). Conditions under which sensory-based interventions were administered, and personnel who provided them, varied across settings.
Conclusion Varied use of sensory-based interventions in the NICU were reported. While this study was limited by biased sampling and the identification of health care professionals' perceptions but not real-world practice, this information can be used to build a comprehensive approach to positive sensory exposures in the NICU.
Variation in Gastrostomy Tube Placement in Premature Infants in the United States
Authors: Greene Nathaniel H. , Greenberg Rachel G. , O'Brien Sean M. , Kemper Alex R. , Miranda Marie Lynn , Clark Reese H. , Smith P. Brian 
Published: December 2018

Objective To describe the variation in surgical gastrostomy tube (SGT) placement in premature infants among neonatal intensive care units (NICUs) in the United States.
Study Design We identified 8,781 premature infants discharged from 114 NICUs in the Pediatrix Medical Group from 2010 to 2012. The outcome of interest was SGT placement prior to discharge home from an NICU. Unadjusted proportions and adjusted risk estimates were calculated to quantify variation observed among individual NICUs.
Results SGT placement occurred in 360 of 8,781 (4.1%) of infants. Across NICUs, any gastrostomy tube placement ranged from none in 45 NICUs up to 19.6%. Adjusted risk estimates for factors associated with SGT placement included gestational age at birth (odds ratio [OR]: 0.7/week, 95% confidence interval[CI]: [0.65, 0.75]), small for gestational age status (OR: 2.78 [2.09, 3.71]), administration of antenatal steroids (OR: 0.69 [0.52, 0.92]), Hispanic ethnicity (OR: 0.54 [0.37, 0.78]), and higher 5-minute Apgar scores (7–10, OR: 0.54 [0.37, 0.79]).
Conclusion Individual NICU center has a strong clinical effect on the probability of SGT placement relative to other medical factors. Future work is needed to understand the cause of this variation and the degree to which it represents over or under use of gastrostomy tubes.
Histological and morphological studies of cardiac cells in response to aerobic exercise and rosemary extract in rat model of aging
Authors: Ababzadeh Shima , Iravani Amir , Fallahian Faranak , Aghamiri Seyed 
Published: December 2018

Objective The average age of the world population is growing increasingly. Since aging is the biggest risk factor for cardiac diseases, the incidence of these types of disease will increase significantly in the near future. However, their occurrence may be prevented by some factors, such as the practice of aerobic exercise and the use of herbal medicine.
Materials and methods Thirty male Wistar rats, at 18 months old each, were divided into 5 groups (n = 6): control (NO), gavage (GO), exercised (EO), extract-fed (EXO), and exercised and extract-fed (EEO). The animals of the GO group received distilled water and were put on a silent electric running machine. The animals of the EO and EEO groups were assigned to a treadmill training protocol at low and moderate intensities for 1 hour/day, 5 days/week for 12 weeks. The animals of the EXO and EEO groups were treated with rosemary (Rosmarinus officinalis) extract for 12 weeks. At the end of the experiment, the hearts of the rats were collected and submitted to hematoxylin and eosin and Mallory trichrome staining. Images of these stained samples were captured, and a morphometric analysis of the cardiac tissue was performed.
Results The rats in the EO, EXO and EEO groups showed a reduction in the intercellular space when compared with those of the NO and GO groups. The rats in the EO and EEO groups showed an increase in the clarification of the intercalated discs and in the width of the cardiomyocytes, when compared with those in the other groups. The nuclei of the heart cells of the animals in the EXO group were seen as more euchromatic than others.
Conclusion Aerobic exercise causes changes in the cardiac muscles of rats and confirms the capacity of the fibers to adapt to the requirements of the proposed aerobic exercise. The antioxidants found in rosemary extract improve cell activity to achieve a better performance. However, applying these two factors simultaneously indicates the reduction of their positive influences.
Dravet Syndrome and Psychiatric Comorbidity
Authors: van Gemert Lisette , Gunning W. 
Published: December 2018

AbstractThis is a review of the prevalence of psychiatric comorbidity in patients with Dravet syndrome (DS) and the predictors of psychiatric comorbidity. Symptoms of attention-deficit hyperactivity disorder are most frequently reported in children with DS. Autistic features and “other behavior problems” are also found in a considerable proportion of children. No consistent relationship has been found with intellectual disability level, age of onset of seizures, delay in diagnosis, and seizure frequency. A major limitation of the literature is that formal psychiatric assessment has rarely been applied.
Asymmetric oxidation of 1,3-propanediols to chiral hydroxyalkanoic acids by Rhodococcus sp. 2N
Authors: Kikukawa Hiroshi , Koyasu Rena , Yasohara Yoshihiko , Ito Noriyuki , Mitsukura Koichi , Yoshida Toyokazu 
Published: December 2018

ABSTRACT
Rhodococcus sp. 2N was found as a 1,3-propanediols-oxidizing strain from soil samples through enrichment culture using 2,2-diethyl-1,3-propanediol (DEPD) as the sole carbon source. The culture condition of the strain 2N was optimized, and the highest activity was observed when 0.3% (w/v) DEPD was added in the culture medium as an inducer. Chiral HPLC analysis of the hydroxyalkanoic acid converted from 2-ethyl-2-methyl-1,3-propanediol (EMPD) revealed that the strain 2N catalyzed the (R)-selective oxidation of EMPD. The reaction products and intermediates from DEPD and EMPD were identified by nuclear magnetic resonance analyses, and the results suggested that only one hydroxymethyl group of the propanediols was converted to carboxy group via two oxidation steps. Under optimized conditions and after a 72-h reaction time, the strain 2N produced 28 mM (4.1 g/L) of 2-(hydroxymethyl)-2-methylbutanoic acid from EMPD with a molar conversion yield of 47% and 65% ee (R).
Immunogenicity of the Varicella-Zoster Vaccine in Community-Dwelling Non-robust Elderly Individuals Compared to Robust Elderly Individuals: A Prospective Cohort Study
Authors: Choi Jung-Yeon , Kang Min-gu , Park Kyoung Un , Park Wan Beom , Kim Kwang-il , Kim Eu Suk , Kim Hong Bin , Song Kyoung-Ho , Kim Cheol-Ho 
Published: December 2018

Abstract
To determine whether immunogenicity of the herpes zoster live-attenuated vaccine (ZVL) in elderly individuals is influenced by frailty status and cytokine levels, individuals aged at least 65 years were prospectively administered ZVL after their frailty status and cytokine levels were assessed. Humoral and cellular immunogenicity were assessed using enzyme-linked immunosorbent assays for the varicella-zoster virus–specific IgG antibody and varicella-zoster virus–specific enzyme-linked immunospot assays, before and 6 weeks after vaccination. We enrolled 69 participants (mean age, 74.3 years); 31 were non-robust. Thirty-seven participants had a greater than 2 geometric mean fold rise in IgG antibodies, 22 more participants had at least 10 spot-forming cells/106 peripheral blood mononuclear cells (from 35 to 57 participants), and 42 experienced a twofold geometric mean fold rise increase of spot-forming cells 6 weeks after vaccination. The geometric mean fold rises of the antibody titers were similar in the robust and non-robust groups; moreover, the baseline enzyme-linked immunospot assay geometric mean values were not significantly different before or 6 weeks after vaccination. We observed no significant correlations between baseline cytokine levels and immunogenicity. Approximately half of the community-dwelling elderly participants in this study experienced a twofold rise in antibodies and one-third more participants showed at least 10 spot-forming cells after ZVL administration, suggesting that the ZVL can boost immunity in non-robust (especially pre-frail) and robust elderly individuals.
Associations Between Cognitive Abilities and 20-Year Personality Changes in Older Adults in the ILSE Study: Does Health Matter?
Authors: Wettstein Markus , Tauber Benjamin , Wahl Hans-Werner 
Published: December 2018

Abstract

Objectives
We used data from the Interdisciplinary Longitudinal Study on Adult Development (ILSE study) to investigate whether associations of cognitive abilities with late-life personality changes are moderated by individuals’ physical health.

Method
Individuals born between 1930 and 1932 (n = 473; mean baseline age: 62.87 years) were assessed up to four times over a period of about 20 years (M = 20.34 years). Cognitive abilities were assessed based on multiple tests representing various cognitive functions. In addition, the Big Five personality traits were measured. Study participants’ health was rated by a physician based on several in-depth medical examinations.

Results
Health appeared as a significant moderator of the associations between cognitive abilities and personality trajectories: First, lower cognitive abilities were associated with an increase in neuroticism in individuals with poor health, but not in those with good health. Second, lower cognitive abilities were related with an increase in agreeableness in older adults with good health, but with a decrease in agreeableness among those with poor health. Third, better cognitive abilities were associated with stability in conscientiousness, but only among individuals with poorer health.

Discussion
Our findings suggest that once health is compromised, cognitive abilities may become a compensatory resource to prevent undesirable personality changes.
Inter-Individual Variability in Trajectories of Functional Limitations by Race/Gender
Authors: Lin Jielu 
Published: December 2018

AbstractObjectiveSeveral theories emphasize that systematic interindividual divergence is a key feature of cohort aging and evidence for accumulative social inequality over the life course. While many have documented widening health gaps with age between subgroups, such divergence is only one aspect of the broader social inequality based on race and gender. This article examines patterns of interindividual variability in trajectories of functional limitations within each race/gender.MethodsUsing data from the Health and Retirement Study (HRS)’s HRS cohort (born 1931–1941), I estimate growth curves of functional limitations with Level 2 heteroscedasticity, allowing interindividual variability to differ across 4 groups: white men, black men, white women, and black women. I examine race/gender differences in the age-based pattern of interindividual variability using an interquartile range of estimated individual trajectories.ResultsBlack men, white women, and black women have greater interindividual variability in functional limitations than do white men. Interindividual variability increases systematically with age at similar rates for all groups but black women.DiscussionFunctional limitations become more heterogeneous with age for the entire cohort and for white men, white women, and black men. Future research should identify life-course processes that generate the race and gender patterning of interindividual variability in late-life health.
Farnesol inhibits planktonic cells and antifungal-tolerant biofilms of Trichosporon asahii and Trichosporon inkin
Authors: Cordeiro Rossana de Aguiar , Pereira Lívia Maria Galdino , de Sousa José Kleybson , Serpa Rosana , Andrade Ana Raquel Colares , Portela Fernando Victor Monteiro , Evangelista Antônio José de Jesus , Sales Jamille Alencar , Aguiar Ana Luiza Ribeiro , Mendes Patrícia Bruna Leite , Brilhante Raimunda Sâmia Nogueira , Sidrim José Júlio da Costa , Castelo-Branco Débora de Souza Collares Maia , Rocha Marcos Fabio Gadelha 
Published: December 2018

Abstract
Trichosporon species have been considered important agents of opportunistic systemic infections, mainly among immunocompromised patients. Infections by Trichosporon spp. are generally associated with biofilm formation in invasive medical devices. These communities are resistant to therapeutic antifungals, and therefore the search for anti-biofilm molecules is necessary. This study evaluated the inhibitory effect of farnesol against planktonic and sessile cells of clinical Trichosporon asahii (n = 3) andTrichosporon inkin (n = 7) strains. Biofilms were evaluated during adhesion, development stages and after maturation for metabolic activity, biomass and protease activity, as well as regarding morphology and ultrastructure by optical microscopy, confocal laser scanning microscopy, and scanning electron microscopy. Farnesol inhibited Trichosporon planktonic growth by 80% at concentrations ranging from 600 to 1200 μM for T. asahii and from 75 to 600 μM for T. inkin. Farnesol was able to reduce cell adhesion by 80% at 300 μM for T. asahii and T. inkin at 600 μM, while biofilm development of both species was inhibited by 80% at concentration of 150 μM, altering their structure. After biofilm maturation, farnesol decreased T. asahii biofilm formation by 50% at 600 μM concentration and T. inkin formation at 300 μM. Farnesol inhibited gradual filamentation in a concentration range between 600 and 1200 μM. Farnesol caused reduction of filament structures of Trichosporon spp. at every stage of biofilm development analyzed. These data show the potential of farnesol as an anti-biofilm molecule.