bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining and Measuring Crewmember Operational State for Spaceflight Operations
Authors: Zero Michael , Klaus David , Arquilla Katya , Fanchiang Christine 
Published: November 2024

INTRODUCTION: A suite of human health and performance metrics can be used to provide a holistic cognitive, physical, and emotional view of an individual and assess how well they are integrated with the overall system during spaceflight missions. The combination of such individual metrics as defined here is notionally termed “crewmember operational state.”
METHODS: This work identifies and defines the contributing components that comprise the proposed crewmember operational state.
RESULTS: Considerations of how to measure the components in a spaceflight environment are summarized and the steps required to analyze and integrate these measurements into an operational framework are outlined. Use of the measurements and integration steps are then extended into several applications relevant to human spaceflight mission design and operations.
DISCUSSION: For the framework and applications defined here to become operationally feasible, several limitations and gaps that remain to be addressed are presented with recommended future research and enabling technology advancement needs.
Zero M, Klaus D, Arquilla K, Fanchiang C. Defining and measuring crewmember operational state for spaceflight operations. Aerosp Med Hum Perform. 2024; 95(12):919–929.
Facial Expression Perception and Psychological Changes During Space Analogs
Authors: Van Hoy Scott 
Published: November 2024

INTRODUCTION: Facial expression perception is the process by which someone can interpret the emotion of another individual using their facial cues. Below-average scores on tests designed to measure facial expression recognition (FER) accuracies are associated with inappropriate behavioral responses and are often linked to mental or neurological disorders. Head-down bed rest microgravity analog studies show changes in facial emotion processing that may indicate a behavioral health risk during spaceflight.
METHODS: During short-duration space analog missions at two separate facilities, 15 subjects took daily FER tests before, during, and after the mission. Each test was accompanied by questionnaires measuring either potential causal or impacted variables: stress, depression, loneliness, irritability, risk-taking, empathy, and intrinsic motivation.
RESULTS: Analysis of variance and post hoc t-tests showed that during the mission, the subjects were less likely to identify angry, sad, or fearful faces as disgusted compared to the baseline. Also, interest/enjoyment and perceived competence increased throughout the mission lifecycle. Multiple regression analyses were able to account for greater than 20% of the variance for depression and health/safety risk-taking using the FER data.
DISCUSSION: Changes in FER during space mission simulations show that perception changes are not limited to microgravity analogs. A perceptual change was observed during the short-duration missions, but there is not sufficient evidence to show behavioral health impacts. However, associations between FER and the questionnaires show a potential to develop predictive models, countermeasures, or psychological monitoring tools using FER. Additional research is required to determine the efficacy of such tools during long-duration spaceflight.
Van Hoy S. Facial expression perception and psychological changes during space analogs. Aerosp Med Hum Perform. 2024; 95(12):913–918.
Association between the systemic immune-inflammation index and the outcome of liver fibrosis in patients with chronic hepatitis C
Authors: Ma Yuanji , Wang Jiayi , Du Lingyao , Tang Hong 
Published: November 2024

BackgroundRisk factors that influence the outcome of patients with chronic hepatitis C (CHC) are not fully understood. The systemic immune-inflammatory index (SII) is an independent prognostic factor for multiple diseases. However, the impact of the SII on the outcome of liver fibrosis is unclear.MethodsThis prospective real-world study enrolled patients with CHC treated with sofosbuvir/velpatasvir. Logistic regression models were used to investigate the relationship between the SII and the outcome of liver fibrosis in treatment-naive patients. Liver fibrosis was assessed using aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4).ResultsOf the 288 participants, the SII was 238.2 (153.0–358.2). The non-improved outcomes of liver fibrosis assessed with APRI (non-improved APRI) and FIB-4 (non-improved FIB-4) were 83.0 and 87.5%, respectively. Adjusted models showed that the SII was positively associated with non-improved APRI (adjusted OR (95% CI): 1.013 (1.009–1.017), p &lt; 0.001) and FIB-4 (adjusted OR (95% CI): 1.004 (1.001–1.007), p = 0.012). Similarly, a higher SII was associated with a higher risk of non-improved APRI (adjusted OR (95% CI): 13.53 (5.60–32.68), p &lt; 0.001) and FIB-4 (adjusted OR (95% CI): 5.69 (2.17–14.90), p &lt; 0.001). The association with non-improved APRI was much more remarkable in patients with alanine aminotransferase &lt;2 ULN, and the association with non-improved FIB-4 was remarkable in patients aged &lt;50 years. Multiple imputation analyses confirmed the robustness of these results.ConclusionOur findings suggested that the SII was positively associated with non-improved outcomes of liver fibrosis in patients with CHC. These results need to be validated in large-scale prospective cohorts.
Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China
Authors: Liang Hui , Liu Yao , Yin Suyue , Jiang Mengyu , Dou Qiuyan , Wang Hanhan , Liu Jie , Chen Yibo , Liu Pei , Wang Jing , Wang Yishan , Wu Zhe 
Published: November 2024

ObjectiveThis study aimed to evaluate the clinical utility of PAX1/JAM3 methylation (CISCER) test in triaging high-risk human papillomavirus (hrHPV)-positive women.MethodsWe enrolled women who underwent opportunistic screening at Cervical Disease outpatient clinics of Xuzhou Maternity and Child Health Hospital, and Yueyang Central Hospital from December 2022 to May 2024. The effectiveness of CISCER and cytology tests in triaging hrHPV+ patients was analyzed.ResultsAmong the 436 study participants, 283 (64.9%) had no cervical intraepithelial neoplasia (CIN), while 53 (12.2%) had CIN1, 40 (9.2%) had CIN2, 34 (7.8%) had CIN3, and 26 (5.9%) had cervical cancers. The CISCER tests identified all cases of cervical cancer, particularly 2 hrHPV-negative adenocarcinoma cases. In 396 hrHPV+ individuals, the sensitivity of CISCER tests for detecting CIN2+ lesions was 92.6% (95% CI: 87.2-97.9%), with a specificity of 95.7% (95% CI: 93.4-98%), and an area under the receiver operating characteristic curve (AUC) of 0.941 (95% CI: 0.903-0.979), outperforming cytology tests in both HPV16/18+ and non-16/18 hrHPV+ women. Notably, CISCER demonstrated 100% (95% CI: 90-100%) sensitivity in women aged≥50 and 100% (95%CI: 93.6-100%) specificity in women aged&lt;30. Among CIN2+ women, 37.2% (including 3 cancer) showed low-grade cytological changes that could be detected by CISCER. Meanwhile, 52% of CIN2- women exhibited cytological abnormalities but had negative CISCER results. The immediate CIN3+ risk based on positive CISCER results was 54% (95% CI: 43.8-63.9%).ConclusionThe PAX1/JAM3 methylation detection using cervical exfoliated cells showed superior triage performance for hrHPV-positive patients compared to traditional strategies.
GNA14 may be a potential prognostic biomarker in nasopharyngeal carcinoma
Authors: Hao Jinrong , Yu Xia , Xiong Lei , Deng Li , Lian Shifeng , Sun Shijun , Li Xiaoling , Du Yun , Ji Mingfang 
Published: November 2024

BackgroundNasopharyngeal carcinoma (NPC) is a highly invasive malignant tumor. Recurrence and distant metastasis represent the primary causes of treatment failure. This study aimed to identify biomarkers highly associated with NPC and investigate its roles in tumor progression.MethodsTranscriptome sequencing (RNA-seq) data of NPC and normal tissues were downloaded from the Gene Expression Omnibus (GEO) database. By analyzing the RNA-seq data, we found that G Protein Subunit Alpha 14 (GNA14) is closely associated with the diagnosis and prognosis of NPC. Immunohistochemistry (IHC) was used to detect the expression of GNA14 in tumor tissues of 165 NPC patients, and we analyzed the relationship between GNA14 expression and patient prognosis. The potential mechanisms by which GNA14 affects tumor prognosis were preliminarily analyzed using bioinformatics analysis.ResultsAnalysis of RNA-seq data and IHC showed that GNA14 expression was downregulated in NPC (p &lt; 0.001, p &lt; 0.01, respectively), and low expression of GNA14 was closely associated with poor prognosis. IHC analysis showed that patients with low GNA14 expression had significantly shorter progression-free survival (PFS) and distant metastasis-free survival (DMFS) than those with high GNA14 expression (p = 0.023, p = 0.008, respectively). Multivariate analysis indicated that the GNA14 expression was an independent risk factor for DMFS (p = 0.030). The DMFS nomogram included GNA14 expression, EBV DNA, and N stage as prognostic factors and the concordance index (C-index) of the nomogram was 0.73. Bioinformatics analysis indicated that NPC patients with low GNA14 expression might represent lower levels of immune cell infiltration and poorer drug sensitivity.ConclusionLow GNA14 expression may be a risk factor for poor prognosis in NPC.
Effects of ECMF Isolated from Mining Areas on Water Status, Photosynthesis Capacity, and Lead Ion Transport of Populus alba Under Pb Stress
Authors: Wu Na , Li Zhen , Wu Fei , Tan Jing 
Published: November 2024

Native ectomycorrhizal fungi (ECMF) are generally more effective than non-native ECMF in facilitating the phytoremediation of heavy metal (HM) ions from contaminated soils. This study aimed to investigate the contributions of four ECMF species—Suillus luteus, Suillus flavidus, Suillus variegatus, and Gomphidius glutinosus—that were isolated from mining areas to the growth, water status, photosynthesis, and metallothionein gene expression of Populus alba exposed to varying concentrations of lead (Pb). The experiment lasted two months and involved P. alba cuttings subjected to Pb concentrations of 0, 200, and 400 mg kg−1, representing no Pb stress, moderate Pb stress, and severe Pb stress, respectively. Results indicated that S. flavidus significantly enhanced the growth, water status, photosynthesis parameters, and metallothionein gene expression of P. alba under Pb stress, whereas S. luteus only exhibited positive effects under severe Pb stress. S. variegatus negatively affected the growth, water status, photosynthesis, and metallothionein gene expression of P. alba under Pb stress, while no significant difference was observed between the control treatment and G. glutinosus symbiosis. Therefore, S. flavidus and S. luteus are promising ECMF species for ecological restoration in mining areas, especially in P. alba woodlands.
Гендерные особенности эндотелия у больных гипертонической болезнью
Authors: С.Н. Маммаев , Х.И. Ибрагимова , С.С. Заглиева 
Published: November 2024

Цель: изучить содержание эндотелина-1 в сыворотке крови и гормонально-метаболические показатели у больных артериальной гипертензией (АГ) в зависимости от пола и возраста. Материалы и методы. У 120 больных женщин АГ изучено состояние гормонального статуса, а также эффективность монотерапии ирбесартаном. Результаты. Установлены гендерные и возрастные различия содержания эндотелина-1. У женщин в постменопаузе установлено наличие достоверных корреляционных связей между концентрацией эндотелина-1 и показателями липидного профиля, а также параметрами суточного мониторинга артериального давления. Высокий уровень эндотелина-1 способствует возникновению АГ у женщин в постменопаузе, что свидетельствует о максимальной выраженности эндотелиальной дисфункции и преобладании вазоконстрикторных эффектов эндотелина-1 в периоде постменопаузы. Заключение. Выявленные корреляционные связи подтверждают патогенетическую роль изменения гормонального статуса в прогрессировании эндотелиальной дисфункции и АГ.
Objective. to study the content of endothelin-1 in the blood serum and hormonal-metabolic parameters in patients with arterial hypertension (AH) depending on gender and age Material and methods. In 120 sick women with AH, the state of hormonal status was studied, as well as the effectiveness of irbesartan monotherapy. Results. Gender and age differences in the content of endothelin-1 were established. In postmenopausal women, the presence of reliable correlation between the concentration of endothelin-1 and the lipid profile, as well as the parameters of daily monitoring of blood pressure was established. A high level of endothelin-1 contributes to the occurrence of hypertension in postmenopausal women, which indicates the maximum severity of endothelial dysfunction and the predominance of the vasoconstrictor effects of endothelin-1 in the postmenopausal period. Conclusion. The revealed correlation relationships confirm the pathogenetic role of changes in hormonal status in the progression of endothelial dysfunction and increased blood pressure.
Роль лучевых методов исследования в диагностике остеопороза
Authors: С.А. Абдулкадыров , П.А. Таибова , У.Г. Акамова 
Published: November 2024

Цель данной статьи показать актуальность проблемы и современные методы диагностики и профилактики остеопороза у пациентов разного возраста и пола. Материалы. Использованы материалы научных статей и монографий, данные ВОЗ. Результаты. Анализ применения различных методов исследования, их преимущества и недостатки. Рентгеновская абсорбциометрия в настоящее время является наилучшим методом диагностики остеопороза и оценки риска переломов. Заключение. Диагноз остеопороза зачастую устанавливается после травматических повреждений. Ранняя диагностика остеопороза имеет огромное значение для предотвращения осложнений , приводящих к инвалидизации больных .На сегодняшний день медицина располагает различными возможностями диагностики данной патологии, основанными на использовании высокотехнологичных методов лучевой диагностики.
The purpose. of this article is to show the relevance of the problem and modern methods for the diagnosis and prevention of osteoporosis in patients of different ages and sex. Materials. The materials of scientific articles and monographs used by WHO are used. Results. Analysis of the application of various research methods, their advantages and disadvantages. X-ray absorptiometry is currently the best method for diagnosing osteoporosis and assessing the risk of fractures. Conclusion The diagnosis of osteoporosis is often established after traumatic injuries. Early diagnosis of osteoporosis is of great importance to prevent complications leading to disability of patients. Today, medicine has various diagnostic capabilities for this pathology, based on the use of high-tech methods of radiation diagnosis.
«НАНОТЕХНОЛОГИИ», КАК ФАКТОР РАЗВИТИЯИННОВАЦИОННОГО ПОТЕНЦИАЛА ПРОМЫШЛЕННОСТИ,НАУКИ И НАУЧНОЙ ИНДУСТРИИ
Authors: В.П. Иванников , А.В. Кабакова , Е.А. Кабаков 
Published: November 2024

В настоящее время уровень развития техники и технологий определяет степень удовлетворения жизненных потребностей человека. Чем выше уровень развития, тем более качественную и более надежную продукцию можно изготавливать, тем меньше уровень отрицательного воздействия человека на природу, экологические риски и, в конечном итоге, выше уровень независимости и свобод, который может позволить себе каждая личность, общество и государство в целом. В этой связи, совершенствование техники и технологий на современном этапе научно-технического развития является важнейшим фактором реализации инновационного потенциала промышленности, науки и научной индустрии и направлено на развитие ресурсосберегающих, безотходных технологий, что ведет, в свою очередь, к совершенствованию организации, управлению и росту эффективности производства.
Annotation. These days the level of engineering and technologies development define the degree of satisfaction of a man living needs. Higher the development level, higher quality and reliable product we can produce and lower the level of negative influence of a human beings on the nature, eco-risks and as a result higher the level of independence and freedom, which every person can achieve as well as society and nation. In that context advance of engineering and technologies at the present stage of scientific and technical development is one of the most important factors of realization of innovation potential of manufacturing, science and scientific industry. It is directed to the development of resource-saving, unwaste technologies, which leads further to advanced organization and management and rise in the efficiency of production.
ПОЛИГОНЫ ТВЕРДЫХ БЫТОВЫХ ОТХОДОВ И СВАЛКИ КАК ДОПОЛНИТЕЛЬНЫЕ ИСТОЧНИКИ УГЛЕВОДОРОДНОГО СЫРЬЯ И ОБЪЕКТЫ ЭКОЛОГИЧЕСКОГО МОНИТОРИНГА
Authors: М.Я. Боровский , С.В. Шакуро , А.С. Борисов , В.И. Богатов 
Published: November 2024

Рассмотрены аспекты промышленного использования свалочного газа (биогаза) в качестве альтернативного источника энергии в западных странах и в России. Подчеркнуты негативное влияние полигонов ТБО на окружающую среду и необходимость ведения экологического мониторинга. Для определения тенденции развития загрязнения окружающей среды сформулирована стадийность геофизических исследований свалок и полигонов твердых бытовых отходов. Приведены примеры использования электротомографии. Продемонстрирована возможность использования карт площадного распределения электрических свойств для оценки защищенности геологической среды от негативного воздействия процессов, происходящих в теле полигонов ТБО и свалок.
Aspects of industrial use of landfill gas (biogas) as an alternative energy source in Western countries and in Russia are considered. The negative impact of landfills on the environment and the need for environmental monitoring are emphasized. In order to determine the development trend of environmental pollution, a stage-by-stage geophysical survey of landfills and solid waste landfills is formulated. Examples of using electrotomography within solid waste landfills are given. The possibility of using maps of the area distribution of electrical properties to assess the protection of the geological environment from the negative impact of processes occurring in the body of solid waste landfills and landfills is demonstrated.
ОСНОВНЫЕ ПОДХОДЫ К СОКРАЩЕНИЮ КОЛИЧЕСТВА ОТХОДОВ НА ПРЕДПРИЯТИЯХ
Authors: А.Н. Журавлева , А.С. Игонина , И.В. Копысова 
Published: November 2024

На основе анализа систем обращения с отходами ряда предприятий выявлены общие закономерности по сокращению количества отходов на производстве. Внедрение системы раздельного сбора отходов позволяет уменьшить количество отходов, выделить полезные компоненты и реализовать их предприятиям-переработчикам. Благодаря этому происходит сокращение количества отходов и уменьшение затрат. Создание и внедрение системы электронного документооборота на предприятиях позволяет снизить затраты на покупку бумаги и уменьшить количество бумажных отходов. Создание замкнутой системы обращения с отходами на предприятии позволяет использовать отходы одного производства в качестве первичного материала для другого. В качестве примера рассмотрена относительно замкнутая система обращения с отходами в химической лаборатории. Рассмотрены варианты по организации системы раздельного сбора отходов для коммунально-бытовой сферы, а также электронного документооборота среди населения.
Based on the analysis of waste management systems of a number of enterprises, General patterns for reducing the amount of waste in production have been identified. The introduction of a separate waste collection system allows you to reduce the amount of waste, allocate useful components and sell them to recycling companies. This reduces the amount of waste and reduces costs. Creating and implementing an electronic document management system at enterprises allows you to reduce the cost of buying paper and reduce the amount of paper waste. Creating a closed waste management system at the enterprise allows using waste from one production as the primary material for another. A relatively closed waste management system in a chemical laboratory is considered as an example. Options for organizing a system of separate waste collection for the utility sector, as well as electronic document management among people, are considered.
СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ УТИЛИЗАЦИИ ОТХОДОВ НА ЖЕЛЕЗНОДОРОЖНОМ ТРАНСПОРТЕ
Authors: О.А. Ганаева , Н.В. Лугаськова 
Published: November 2024

Степень воздействия железнодорожного транспорта на окружающую среду достаточно велика. В статье рассматривается современное состояние проблемы утилизации отходов на железнодорожном транспорте. Проведен анализ системы образования загрязнений, выявлены основные виды отходов и способы обращения с ними, исследованы причины вредных выбросов от предприятий железнодорожного транспорта. Приведены текущие результаты совершенствования системы образования и утилизации отходов. Рассмотрены стратегические цели в области экологического развития предприятий железнодорожного транспорта. Отрицательное влияние железнодорожного транспорта на окружающую среду требует постоянной комплексной профилактической работы, так как ущерб, наносимый среде, приобретает глобальный характер. Необходимо разрабатывать новые технологии и методы обращения с отходами железнодорожной отрасли.
The solving of environmental problems is becoming one of the priorities of Russia's development. The impact of rail transport on the environment is quite high. This article is about current stituation of the problem of waste disposal in railway transport. The analysis of the pollution generation system was carried out, the main types of waste and ways of handling them were identified. The causes of harmful emissions from railway transport enterprises were investigated. The current results of improving the system of education and waste disposal are presented. Strategic goals in thesection of ecological development of railway transport enterprises are considered. The negative impact of railway transport on the environment requires continuous comprehensive preventive work. Based on the conducted research, the author revealed that every year this influence causes more and more damage, which has already acquired a global character. It is necessary to develop the new technologies and methods of waste management in the railway industry.