bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Factors in Treatment Satisfaction in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Chari Ajai , Romanus Dorothy , DasMahapatra Pronabesh , Hoole Michael , Lowe Maria , Curran Chris , Campbell Scott , Bell Jill A. 
Published: August 2019

Abstract

Background
Therapy choices in relapsed/refractory multiple myeloma (RRMM) should consider patient satisfaction with treatment, because it is associated with adherence to therapy, health outcomes, and medical safety. The primary objective of this pilot cross-sectional observational study was to ascertain factors associated with patient-reported treatment satisfaction in RRMM.

Patients and Methods
Patients with a self-reported diagnosis of RRMM recruited from PatientsLikeMe, MyelomaCrowd, and Facebook were administered an electronic survey that included questions on demographics and clinical history, treatment experience, economic burden, and standardized patient-reported outcome measures, including the Treatment Satisfaction Questionnaire for Medication, Eastern Cooperative Oncology Group performance status (ECOG PS) measure, and Work Productivity and Activity Impairment Questionnaire: Specific Health Problem V2.0. Univariable and multivariable analyses were used to identify predictors of patient-perceived treatment satisfaction.

Results
One hundred sixty patients with RRMM participated in the study, with a median of two prior relapses and 66.3% reporting the most recent relapse within the last 12 months. ECOG PS ≥2 was associated with lower patient-reported global satisfaction and perceived effectiveness of current treatment. In addition to shorter time spent receiving therapy, orally administered treatment was the strongest predictor of higher satisfaction with treatment convenience. For patients receiving an injectable drug-containing regimen versus an all-oral regimen, respectively, time spent receiving multiple myeloma-directed therapy was higher (12.6 vs. 4.0 hours per month), and total monthly indirect costs were $1,033 and $241.

Conclusion
Poor ECOG PS was linked to reduced treatment satisfaction and perceived effectiveness of current therapy, whereas an all-oral regimen was associated with increased treatment convenience satisfaction.

Implications for Practice
This study suggests that attributes including better Eastern Cooperative Oncology Group performance status, less time spent receiving treatment, and oral route of treatment administration lead to higher patient-perceived satisfaction with relapsed/refractory multiple myeloma (RRMM) treatment. Oral route of administration was also associated with less time spent receiving treatment and reduced economic burden for patients. Increased attention to these factors in shared treatment decision making is warranted to help identify individual patient needs, preferences, and expectations for RRMM treatments, to resolve dissatisfaction issues, and to improve the experience of patients with RRMM.
The use of psychometric methods for the diagnosis of anxiety and depressive disorders in patients with a general somatic profile
Authors: Dubatova I V , Voyakina V G , Lepyavka S V , Safronenko A V , Demidov I A 
Published: August 2019

Aim. To identify and compare the level of anxiety and depression in therapeutic patients with somatic pathology, establish the structure of the gender distribution of anxiety and depressive disorders.
Methods. The study involved 126 people: 74 (58.73%) women and 52 (41.27%) men aged 21–59 years. 59 patients had diseases of the respiratory system (chronic bronchitis in the acute stage with an asthmatic component), 67 patients with cardiovascular diseases (40 subjects with coronary heart disease, 27 subjects with arterial hypertension). In 11 patients with coronary artery disease and 13 patients with hypertension, type I thyrotoxicosis was diagnosed. Clinical psychopathological, psychometric, psychological and statistical methods were used in the study. Psychometric tests were used: the Depression Scale of the Center for Epidemiological Research; Hospital Anxiety and Depression Scale and Taylor Anxiety Disorder Scale adapted by T.A. Nemchinova and V.G. Norakidze, adapted standardized multivariate questionnaire for personality research.
Results. According to the severity of anxiety and depressive disorders, patients were divided into the groups: group 1 with severe level, group 2 with a moderate (subclinical) level, and group 3 with mild (not exceeding the norm) anxiety and depressive disorders. Severe and moderate disorders are most characteristic for the pathology of cardiovascular system. In coronary artery disease and arterial hypertension, abnormal (severe and moderate) anxiety and depressive disorders were observed in 24/29 (82.76%) and 20/22 (90.9%) patients, respectively. In patients with abnormal anxiety and depressive disorders, the number of women prevailed over men in the subgroup with hypertension (80% versus 20%, p=0.025) as well as in combination of hypertension with type 1 thyrotoxicosis (85.7% versus 14.3%, р=0.029).
Conclusion. In patients, severe and moderate anxiety and depressive disorders are associated with the development of the pathology of cardiovascular system: coronary heart disease and arterial hypertension.
Microanatomy of vitreoretinal interactions in macular and paramacular areas
Authors: Lyskin P V 
Published: August 2019

Aim. To refine microanatomy of vitreoretinal interactions in central areas of retina and to obtain additional information on vitreoretinal interactions regarding theoretical possibility of collagen synthesis in the vitreous body of adult humans and mechanisms of vitreoretinal adhesion.
Methods. Scanning electron microscopy study was performed in central areas of human retina after removal of vitreous base from its surface.
Results. On the surface of retina we found a thin layer of epiretinal vitreous body most strongly bound to the retina. Thickness of paramacular epiretinal vitreous is 3–5 µm and it is formed mainly by thin densely packed fibrils. Its surface layer facing the vitreous cavity consists of the thickest (1 µm) and longest (250 µm) fibrils loosely packed. These fibrils look like “pearl threads” and exhibit signs of newly formed fibrils. Epiretinal layer of the vitreous in the fovea is thinner, its thickness is about 2 µm. Top layer of fibrils is least densely packed with the thickness of the fibrils of about 0.2 µm. The closer to internal limiting membrane, the thinner the fibrils, the denser their packing. The discovered layer can be interpreted as an additional anatomic structural unit of the vitreous body — epiretinal vitreous.
Conclusion. We detected indirect signs of lifetime synthesis of newly formed fibrils in the vitreous of adult human; newly formed collagen may be localized in epiretinal vitreous which may be the main binding component providing vitreoretinal adhesion.
Laser treatment of chronic central serous chorioretinopathy with a point of leakage in the subfoveolar zone without fluorescein angiography
Authors: Samoylov A N , Korobitsin A N 
Published: August 2019

Aim. Develop a methodology and evaluate the clinical results of laser treatment of patients with chronic central serous chorioretinopathy in the presence of a leakage point in the foveola zone.
Methods. The results of patients (32 eyes) with central serous chorioretinopathy after laser exposure in the avascular area were analyzed. The best-corrected visual acuity in these patients before treatment was 0.7 to 1.0 (average 0.78±0.15) with a height of neuroepithelial detachment of 162 to 328 μm according to optical coherence tomography. No signs of choroidal neovascularization was detected in angio mode on optical coherence tomography. The treatment was performed with an Ellex Integre Pro Scan 561 nm. The follow-up examination was performed in 1 and 6 months.
Results. In 1 month, positive dynamics of both functional and anatomical parameters was noted in all eyes. According to the optical coherence tomography, a complete attachment of the neuroepithelium in the central zone of the retina occurred, detachment of the neuroepithelium was absent. Best-corrected visual acuity in 1 month after treatment increased to 0.89±0.08, in 6 months to 0.92±0.04. The study revealed a correlation between visual acuity and the central thickness of the retina in the fovea, there were no complaints about the appearance of scotomas after laser treatment in the foveola zone.
Conclusion. The developed techniqe of laser exposure on the foveola zone in case of chronic central serous chorioretinopathy with a 561 nm laser demonstrated high clinical efficacy and safety and can be recommended to all patients with central serous chorioretinopathy.
Effect of endocrine disrupting chemicals bisphenol A and triclosan on semen quality
Authors: Chigrinets S V , Bryukhin G V 
Published: August 2019

Aim. To establish a relationship between the concentration of endocrine disruptors (bisphenol A, triclosan) in testicular tissues or seminal fluid and semen quality in men and experimental animals.
Methods. 53 samples of seminal fluid were investigated from men with normo- and pathozoospermia. In seminal fluid the level of bisphenol A and triclosan were determined by gas chromatography-mass spectrometry. The spermiological study was carried out according to the World Health Organization guidelines (2010). The experimental part of the study was performed on adult male lab Wistar rats (n=28). The amount of spermatozoa per 1 ml of sperm was determined with the calculation of their motility and atypical forms. The concentration of bisphenol A and triclosan in the testicles was measured by gas chromatography-mass spectrometry.
Results. Bisphenol A and triclosan were detected in 100 and 84.9% of the ejaculate samples with a median concentration of 0.15 (0.06–0.31) ng/ml and 0.13 (0.05–0.22) ng/ml, respectively. With the Spearman's rank correlation coefficient, statistically significant correlation was found between the concentration of endocrine disruptors and ejaculate parameters: between bisphenol A and the total count of spermatozoa, their concentration, the proportion of progressively motile spermatozoa, the proportion of spermatozoa with normal morphology and degree of sperm DNA fragmentation. Triclosan concentration correlated with the proportion of spermatozoa with normal morphology and the degree of sperm DNA fragmentation. The experimental part of the study demonstrated that bisphenol A reduced the total number of spermatozoa with an increase in the proportion of atypical forms of spermatozoa and a violation of the proportion of fertile spermatozoa compared to the group of intact animals. Triclosan reduced the proportion of progressively motile spermatozoa.
Conclusion. Bisphenol A and triclosan have a negative effect on sperm quality in men and experimental animals.
Determination of felodipine in biological fluids
Authors: Kvachakhiya L L , Shormanov V K , Kononenko N S 
Published: August 2019

Aim. Development of methods for the determination of felodipine in blood and plasma.
Methods. The study object was felodipine [3-ethyl-5-methyl-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate]. The experiments were carried out on model mixtures of felodipine with blood and human blood plasma. Acetone was proposed as an isolating agent for the extraction of felodipine from biological fluids. To identify and quantify felodipine in extracts from blood and plasma, the methods of thin-layer chromatography, spectrophotometry and gas-liquid chromatography in combination with mass spectrometry were proposed.
Results. The possibility of using acetone as an isolating agent to extract felodipine from biological fluids is demonstrated. The optimal conditions for the extraction of felodipine with acetone were found to be achieved already at 2-fold infusion of a biological object with an isolating agent, if the mass ratio of isolating liquid and biological material at each infusion stage is at least 2:1, and the infusion time is at least 30 minutes. Optimal felodipine purification conditions were achieved in a macrocolumn (15×1 cm) of Silasorb S-18 sorbent of 30 μm with elution of the substance with the polar eluent acetonitrile-water (7:3). The methods of determining felodipine in the blood and plasma were developed. With the content of felodipine of 25 mg in 25 g of biological fluid, the developed methods allow determining 86.01–87.86% in blood and 95.64–96.18% of the substance in blood plasma. The values of the detection limit of felodipine in the blood and plasma by the developed methods are 200 μg/100 g and 150 μg/100 g, respectively.
Conclusion. Methods for the determination of felodipine in biological fluids were developed based on isolating with acetone and purification in the Silasorb S-18 sorbent column; use of these methods allows determining up to 87.86% of the analyte in the blood and up to 96.18% in the blood plasma.
Results of a comprehensive study of expert opinion and social hygienic aspects of doctors of draft boards of the subjects of the Russian Federation
Authors: Sogiyaynen A A 
Published: August 2019

Aim. Examination of expert opinions and social and hygienic aspects of the activities of draft board doctors of the subjects of the Russian Federation.
Methods. The results of an anonymous continuous survey of medical specialists of the military-medical commissions of the military commissariats of the subjects of the Russian Federation (n=646) are presented, who directly conduct military-medical examination of the studied contingent.
Results. When interviewing experts, significant factors were found that affect the health of citizens of draft age and the quality of military medical expertise. Thus, experts assessed the state of health of modern young men as satisfactory in 84% of cases, and in 3.6% as unsatisfactory. 46.5% of medical specialists noted a positive trend in the level of moral and psychological training of the contingent. Over 14% of respondents noted a negative trend in the health status of young men of draft age over the past 5 years. 9.8% of specialists assess the level of treatment and preventive measures among persons of draft age as unsatisfactory, 25.3% of experts consider it necessary to expand the list of mandatory diagnostic studies when preparing citizens for military service. The reasons for the unsatisfactory work of the system for the prevention of diseases among citizens before being drafted for military service, according to medical specialists, are formalism in carrying out activities for the prevention of diseases, lack of subspecialists in health care organizations, especially in remote areas, and the elimination of adolescent service. The state of the regulatory framework governing the relationship of the parties during the medical provision of training and conscription to the military forces of the Russian Federation adversely affects the work of 43.6% of doctors.
Conclusion. An expert opinion of the medical specialists of the military medical commissions of the military commissariats indicates that the main reserves for improving the quality of measures to prepare citizens for military service are the expansion of diagnostic and treatment and prophylactic measures carried out before military conscription.
Clinical case of destructive pulmonary tuberculosis combined with laryngeal tuberculosis
Authors: Naumov A G , Boronin K A , Bokova K V , Zherebyat'eva N S , Zhukova E V , Konygina K S , Sukhova O A 
Published: August 2019

Timely detection of tuberculosis among the population, both pulmonary and, especially, extrapulmonary, is a priority task of domestic and foreign health care. Often, extrapulmonary forms of tuberculosis mask various other pathologies. For example, laryngeal tuberculosis may be masked as a malignant neoplasm or occur as a nonspecific lesion. The purpose of the article is to attract the attention of medical specialists to the problem of diagnosing tuberculosis on the example of a clinical case of a patient with combined pulmonary and laryngeal tuberculosis. In accordance with the obtained clinical, laboratory and instrumental data, we concluded that when patients are admitted to a non-specialized medical organization with complaints from the larynx (dysphonia, aphonia) or oropharyngeal organs (dysphagia), complete diagnostic minimum is required including chest X-ray, complete blood count, otolaryngology consultation and microbiological monitoring (sputum microscopy) for the purpose of integrated examination of the patient and further routing to antituberculous institution. An example is given of successful treatment of a patient with a combination of pulmonary and extrapulmonary tuberculosis (laryngeal tuberculosis) identified due to the presence of symptoms in the larynx.
Boyd-Bowman, Peter (2003): Léxico Hispanoamericano (1493-1993), eds. Ray Harris-Northall y John Nitti, CD-ROM, Nueva York, Hispanic Seminary of Medieval Studies
Authors: Gago Jover Francisco 
Published: August 2019

Reseña: Boyd-Bowman, Peter (2003): Léxico Hispanoamericano (1493-1993), eds. Ray Harris-Northall y John Nitti, CD-ROM, Nueva York, Hispanic Seminary of Medieval Studies.
Sanda Reinheimer Ripeanu (2004): Les emprunts latins dans les langues romanes, Bucarest, Editura Universitatii din Bucureti
Authors: Prat Sabater Marta 
Published: August 2019

Reseña de libro: Sanda Reinheimer Ripeanu (2004): Les emprunts latins dans les langues romanes, Bucarest, Editura Universitatii din Bucureti.
A retrospective study on prevalence, bacteriological profile and antibiotic sensitivity pattern of urinary tract infection in children of 2-12 years age in a tertiary care centre, Puducherry, India
Authors: Angamuthu Dharmalingam , Bhaskar Chandru , Aswathaman Nalini 
Published: August 2019

Background: Urinary tract infections (UTIs) are a common cause of acute bacterial illness in infants and children(1).Diagnosis is often missed in infants and children as urinary symptoms are minimal and nonspecific. It is becoming increasingly difficult to treat due to increasing prevalence of antimicrobial resistance among organisms.Method: It was done as a retrospective cross sectional study conducted on Children of 2-12 years of age suspected to have UTI from January 2018 to December 2018 in Pediatric Department of AVMCH.Results: Out of 286 children with symptoms suggestive of Urinary tract infection, 22(7.7%) were found to have culture positive UTI with 9.2% prevalence in 2-6 years age group as against 6.4% in 7-12 years of age group. Culture positive UTI was predominantly found in males in 2-6 years age group as against female predominance in 7-12 years age group. E. coli (45.5%) was the commonest organism isolated among them followed by Klebsiella. 90% of organisms were sensitive to Nitrofurantoin and 80% were sensitive to Amikacin(80%).Discussion: Culture positive UTI rate varies with gender and age group. It was predominantly found in males in 2-6 years age group as against female predominance in 7-12 years age group. E. coli and Klebsieella were the most common organisms with predominant sensitivity to Nitrofurantoin and Amikacin similar to other studies. Limitation of this study Retrospective study, small sample size and follow up for complications not done.Conclusion: This study concludes E. coli and Klebsieella were the most common organisms with predominant sensitivity to Nitrofurantoin and Amikacin. Antibiotics need to be selected based on organisms and their sensitivity pattern.
Production and characterization of mixed pineapple and hibiscus jam
Authors: De Vilela Silva Eugênia Telis , Moura Henrique Valentim , Feitosa de Figueiredo Rossana Maria , De Melo Queiroz Alexandre Jose , Santos Moreira Inácia Dos 
Published: August 2019

Pineapple is a food rich in vitamins, antioxidants and bromelain, but because it has high water content it becomes a highly perishable fruit. Hibiscus is a plant with flowers rich in phytochemicals that can be used as an ingredient to add value to processed products. The objective of this work was to prepare mixed jams using pineapple with hibiscus extract at different concentrations and to characterize the physicochemical properties
of the jams produced. Experimental design was completely randomized with four replicates. The treatments consisted of three concentration levels of hibiscus extract (5, 10 and 15%) in pineapple jelly (50:50). Analyzed physical-chemical characteristics were: water content, water activity, ash, lipids, total sugars, reducing and non-reducing sugars, vitamin C, total titratable acidity, pH and total soluble solids. It was found that increasing
concentrations of hibiscus in the formulations significantly influenced resulting jam composition. Increasing hibiscus concentration reduced the total sugars content and increased ascorbic acid content, acidity, total soluble solids and ash, as well as total anthocyanins and flavonoids contents. Among the jams produced, the formulation with 15% hibiscus was distinguished by its high content of ascorbic acid, flavonoids and anthocyanins. The addition of hibiscus to pineapple jelly improves the nutritional and functional value of the resulting jams, so it can be considered a high potential ingredient for this type of product.
Dagome iudex jako prototyp konkordatów
Authors: Burczak Krzysztof 
Published: August 2019

Reforma Kościoła przeprowadzona w XI w. przez papieża Grzegorza VII (1073-1085) doprowadziła do podniesienia poziomu życia religijnego i dyscyplinarnego. Współpracujący z papieżem w dziele reformy kardynał Deusdedit sporządził Collectio canonum. W dziele tym, w którym zamieścił dokumenty poświadczające terytoria oddane w protektorat Stolicy Apostolskiej, znalazł się regest dokumentu nazwanego od imienia władcy Dagome iudex. Jest to dokument poświadczający oddanie przez Mieszka I państwa polskiego w protektorat Stolicy Apostolskiej. Nakreślone w dokumencie granice państwa, od Morza Bałtyckiego do Prus, na wschodzie Ruś, na południu Morawy, na zachodzie Odra, stanowią historyczny opis piastowskich ziem. Czynność prawna określona w dokumencie przez słowo „contulisse” (przekazać) polegała na przekazaniu państwa polskiego Stolicy Apostolskiej. Za to, państwo polskie zostało przyjęte w protekcję. Spowodowało to nawiązanie pomiędzy państwem polskim i Stolicą Apostolską określonego stosunku prawnego. Protekcja Stolicy Apostolskiej stanowiła moralną ochronę przed jakimkolwiek atakiem państw na terytorium państwa polskiego. Ten akt prawny pociągał za sobą obowiązek płacenia trybutu na rzecz Stolicy Apostolskiej. Celem politycznym decyzji Mieszka I było zabezpieczenie państwa przed atakami państw sąsiednich. Celem dalekosiężnym w obszarze stosunków kościelnych, było umożliwienie budowy własnych struktur kościelnych. Poprzez ten akt prawny Polska weszła w obszar stosunków polityczno-kościelno-prawnych ze Stolicą Apostolską. Dokument Dagome iudex można więc widzieć jako prototyp przyszłych konkordatów, które regulują relacje pomiędzy państwami i Stolicą Apostolską, jak też relacje pomiędzy państwem i Kościołem w danym państwie.
Status prawny dziecka w niemieckim ustawodawstwie w Generalnym Gubernatorstwie (1939-1945)
Authors: Wrzyszcz Andrzej , Mielnik Hubert 
Published: August 2019

Przedmiotem artykuły jest analiza statusu prawnego dziecka w niemieckim ustawodawstwie w Generalnym Gubernatorstwie. Autorzy przedstawiają status dziecka na gruncie różnych aktów prawnych wprowadzonych przez niemieckich okupantów w poszczególnych gałęziach prawa. Ochronne funkcje prawa względem dziecka zostały praktycznie w całości złamane w ustawodawstwie niemieckim w Generalnym Gubernatorstwie. Prawodawcy w Generalnym Gubernatorstwie nie prowadzili zaplanowanej i usystematyzowanej działalności ustawodawczej względem dzieci. Wprowadzone przez niemieckich okupantów przepisy dotyczące dzieci odzwierciedlały jednak najważniejsze cele polityki nazistowskiej. W przepisach dotyczących dzieci w Generalnym Gubernatorstwie widoczne są wszystkie cechy prawa nazistowskiego: rasizm, pogwałcenie podstawowych zasad słuszności i sprawiedliwości. Autorzy analizują w artykule wyłącznie sferę normatywną, pomijając działania podejmowane poza sferą normatywną.