bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goal Recognition Design in Deterministic Environments
Authors: Keren Sarah , Gal Avigdor , Karpas Erez 
Published: July 2019

Goal recognition design (GRD) facilitates understanding the goals of acting agents through the analysis and redesign of goal recognition models, thus offering a solution for assessing and minimizing the maximal progress of any agent in the model before goal recognition is guaranteed. In a nutshell, given a model of a domain and a set of possible goals, a solution to a GRD problem determines (1) the extent to which actions performed by an agent within the model reveal the agent’s objective; and (2) how best to modify the model so that the objective of an agent can be detected as early as possible. This approach is relevant to any domain in which rapid goal recognition is essential and the model design can be controlled. Applications include intrusion detection, assisted cognition, computer games, and human-robot collaboration.
A GRD problem has two components: the analyzed goal recognition setting, and a design model specifying the possible ways the environment in which agents act can be modified so as to facilitate recognition. This work formulates a general framework for GRD in deterministic and partially observable environments, and offers a toolbox of solutions for evaluating and optimizing model quality for various settings.
For the purpose of evaluation we suggest the worst case distinctiveness (WCD) measure, which represents the maximal cost of a path an agent may follow before its goal can be inferred by a goal recognition system. We offer novel compilations to classical planning for calculating WCD in settings where agents are bounded-suboptimal. We then suggest methods for minimizing WCD by searching for an optimal redesign strategy within the space of possible modifications, and using pruning to increase efficiency. We support our approach with an empirical evaluation that measures WCD in a variety of GRD settings and tests the efficiency of our compilation-based methods for computing it. We also examine the effectiveness of reducing WCD via redesign and the performance gain brought about by our proposed pruning strategy.
Emergence of ERBB2 Mutation as a Biomarker and an Actionable Target in Solid Cancers
Authors: Subramanian Janakiraman , Katta Archana , Masood Ashiq , Vudem Dashavantha Reddy , Kancha Rama Krishna 
Published: July 2019

Abstract

The oncogenic role ERBB2 amplification is well established in breast and gastric cancers. This has led to the development of a well-known portfolio of monoclonal antibodies and kinase inhibitors targeting the ERBB2 kinase. More recently, activating mutations in the ERBB2 gene have been increasingly reported in multiple solid cancers and were shown to play an oncogenic role similar to that of ERBB2 amplification. Thus, ERBB2 mutations define a distinct molecular subtype of solid tumors and serve as actionable targets. However, efforts to target ERBB2 mutation has met with limited clinical success, possibly because of their low frequency, inadequate understanding of the biological activity of these mutations, and difficulty in separating the drivers from the passenger mutations. Given the current impetus to deliver molecularly targeted treatments for cancer, there is an important need to understand the therapeutic potential of ERBB2 mutations. Here we review the distribution of ERBB2 mutations in different tumor types, their potential as a novel biomarker that defines new subsets in many cancers, and current data on preclinical and clinical efforts to target these mutations.

Implications for Practice
A current trend in oncology is to identify novel genomic drivers of solid tumors and developing precision treatments that target them. ERBB2 amplification is an established therapeutic target in breast and gastric cancers, but efforts to translate this finding to other solid tumors with ERBB2 amplification have not been effective. Recently the focus has turned to targeting activating ERBB2 mutations. The year 2018 marked an important milestone in establishing ERBB2 mutation as an important actionable target in multiple cancer types. There have been several recent preclinical and clinical studies evaluating ERBB2 mutation as a therapeutic target with varying success. With increasing access to next-generation sequencing technologies in the clinic, oncologists are frequently identifying activating ERBB2 mutations in patients with cancer. There is a significant need both from the clinician and bench scientist perspectives to understand the current state of affairs for ERBB2 mutations.
Ocorrência de Escherichia coli e Klebsiella spp produtoras de ESBL em Hospital Universitário, na cidade de Manaus - AM
Authors: Diniz Alena Mileo Monteiro , Santos Rose Mary Correa Santos 
Published: July 2019

Justificativa e Objetivos:Bactérias produtoras de betalactamase de espectro ampliado (ESBL) são crescentes, sobretudo, pelo uso
rotineiro de antibióticos. Causam principalmente, infecções urinárias e de feridas operatórias e, caracterizam-se pela resistência às cefa-losporinas de terceira geração, aztreonam e associação de cefalosporinas com ácido clavulânico. Este estudo teve como objetivo conhecer
a frequência de Escherichia coli ESBL e Klebsiella spp.ESBL através da análise fenotípica. Métodos:Teste de sensibilidade in vitro por
aproximação de discos (CLSI), de bactérias isoladas de meios biológicos dos pacientes atendidos no HUGV entre 2017 e 2018. Resultados:
34,66% eram Escherichia coli ESBL e 46,80% Klebsiella spp.ESBL, totalizando 39,34% de amostras ESBL. Dos meios biológicos predomina-ram ESBL na: urina (56,25%) e feridas cirúrgicas (22,91%). Clínicas com maior ocorrência de ESBL: médica e cirúrgica. Conclusão: Os índices
de ESBL no HUGV estão próximos ou até mais altos do que em algumas regiões do país. Consoante a literatura revisada, predomina a
Escherichia coli nos isolados e há mais Klebisella spp. ESBL do queEscherichia coliESBL.
Descritores:Fenótipo. Escherichia coli. Klebsiella. ESBL. Infecção Hospitalar
Avaliação da terapia medicamentosa de pacientes idosos portadores de hipertensão arterial sistêmica e diabetes mellitus tipo II atendidos em uma unidade básica de saúde no município de Xanxerê – SC
Authors: Dos Santos Andressa Rodrigues , Senger Franciane Rios 
Published: July 2019

Justificativa e Objetivos:Os idosos representam a parcela da população que mais usa medicamentos, por esse motivo é comum en-contrar erros de medicação entre esses pacientes. A hipertensão e o diabetes são as doenças crônicas mais comuns nos idosos, portanto
os fármacos anti-hipertensivos e hipoglicemiantes merecem atenção e cuidados na administração e dispensação. A pesquisa teve por
objetivo avaliar a farmacoterapia prescrita aos idosos portadores de hipertensão arterial sistêmica e diabetes mellitus tipo 2 atendidos em
uma unidade básica de saúde no município de Xanxerê-SC. Métodos:A pesquisa embasou-se na análise da farmacoterapia, patologias
associadas e dados socioeconômicos de pacientes com hipertensão arterial sistêmica e diabetes mellitus tipo 2. Resultado:Os 20 idosos
incluídos no estudo, tinham média de idade de 70,7 anos (±6,1), com idade mínima de 60 anos e máxima de 84 anos, sendo 70 % do gênero
feminino e 30 % do masculino. O número de medicamentos utilizados variou de 2 a 10, num total de 116 medicamentos em uso pelos
pacientes incluídos no estudo. A média por pessoa foi de 5,8 medicamentos (±2,1). Foram identificadas 56 interações medicamentosas.
Conclusão: Os dados analisados nesta pesquisa demonstram a existência de riscos de resultados negativos relacionados aos medica-mentos em pacientes com hipertensão arterial sistêmica e diabetes mellitus tipo 2. Tais resultados estimulam o desenvolvimento de
mecanismos de avaliação de processos que visem reduzir esses riscos, elevando a chance de resultados terapêuticos positivos e benefícios
para os pacientes.
Descritores: Hipertensão. Diabetes Mellitus. Idosos. Interações Medicamentosas
Analisis Hubungan Self-efficacy dan Metakognitif terhadap Hasil Belajar Siswa SMA Berdasarkan Gender pada Konsep Genetika
Authors: Suherman Dewi Purnamasari , Purwianingsih Widi , Diana Sariwulan 
Published: July 2019

The lower of awareness, motivation, and self regulation students’ on learning is a major concern in science education. The purpose of this research is to analyze the effects of self-efficacy beliefs and metacognitive on academic performance among high school students based on gender on Genetic concept that include sub-concepts: Genetic Mendel, Heredity, and Mutation. Descriptive method is constructed this study. A total of 60 students XII grader of high school are participated in the study. Data were collected by Self-efficacy and Metacognitive Questionnaire, Genetic Concept Test, and Final Questionnaire. Data were analyzed using inferential statistics, regression. Regression analysis indicated that self-efficacy and metacognitive was a strong predictor of academic performance. This case are showed by the value of regression, R = 0.612 so that self-efficacy and metacognitive were inferred was a strong predictor of academic performance. The other finding on this research show that male students are outperforming female students on self-efficacy, metacognitive, and academic performance, so that can be conducted a further research about how to increase level of self-efficacy and metacognitive on female students.
The results of treatment of urogenital system rhabdomyosarcoma in children. 15-years of experience
Authors: Kazanstev A. P. , Jumaniyozov Kh. I. , Kerimov P. A. , Rubanskaya M. V. , Rubanskiy M. A. , Kapkova O. A. , Temnyi A. S. , Abbasov Kh. A. , Khakimov G. A. 
Published: July 2019

Background. Despite significount successes in treatment of rhabdomyosarcoma of urogenital system in children there are unresolved questions of choise of optimal chemotherapys combinations, intensity of chemotherapy, volumes and terms of radiotherapy, tactics of treatment residual tumors in last 3 decades.The objective: show 15 years experience of treatment local and locally prevalent rhabdomyosarcoma urogenital system in children. The prognosis for children and adolescents with rhabdomyosarcoma has improved with refinements in multi-modal therapy.Materials and methods. In reseach are included 86 patients with a median age of 8.4 (0.7–17) with a local genitourinary rhabdomyosarcoma, treated in N.N. Blokhin National Medical Research Centre of Oncology from 2000 to 2016. All patients were treated in different riskadopted clinical protocol included chemotherapy and radiotherapy (IRS, SIOP, CWS and local protocol DORMS-6).Results. A 10-year overall survival and disease-free survival rates were 76 and 72 % in the entire group rhabdomyosarcoma patients, respectively.Conclusion. The effectiveness of the risk-adopted strategy in the genitourinary rhabdomyosarcoma treatment as well as the need of new approaches and in the cases of residual viable tumor after induction chemotherapy was demonstrated.
Natureza, sentidos e integração: caso de estudo do centro Helen Keller
Authors: Romeiras Amado Maria 
Published: July 2019

O foco do meu presente estudo incide no Centro Helen Keller, uma escola privada portuguesa fundada em 1955 com o objetivo de integrar alunos com diversas características de visão, nomeadamente crianças cegas, com baixa visão e normovisuais. Integrada num parque natural de Lisboa com 1012 hectares, esta escola dispõe de uma situação privilegiada para assimilar a natureza na sua potência de educação e convívio a tão diverso corpo discente. Do ponto de vista neurológico, a diversidade sensorial presente é assim desenvolvida pela variedade de estímulos existentes na natureza envolvente, disponíveis para aproveitamento de aprendizagem é o meu principal interesse, para tal acompanhando a história e circunstâncias desta escola integrada, de inspiração Freinet, até aos nossos dias, em que valores como a Ecologia são parte do seu quotidiano.
Invisibilización de la violencia en el noviazgo en Chile: evidencia desde la investigación empírica
Authors: Valdivia Peralta Maruzzella , Fonseca-Pedrero Eduardo , González Bravo Luis , Paíno Piñeiro Mercedes 
Published: July 2019

El presente artículo analiza la violencia en el noviazgo mediante el estudio de sus tasas de prevalencia en Latinoamérica y Chile en las dos últimas décadas, comparándolas con los datos procedentes de otros países. Se constata la relevancia del problema en este último país, donde se llega al 51% en violencia psicológica y al 25% en la física. Se exponen además posibles causas de la poca relevancia y difusión de este problema en las políticas públicas, comparando metodologías e instrumentos de evaluación utilizados.
DEVELOPMENT OF UNIVERSITY TEACHER’S INNOVATIVE CULTURE
Authors: MG Sergeeva , AV Serebrennikova , MV Nikolaeva , EE Suslennikova , NG Bondarenko , AA Shumeyko 
Published: July 2019

Purpose: The aim of research is to analyze the development of university teacher’s innovative culture.
Methodology: This is an analytical-descriptive research that obtained data from questionnaires and interviews. Content analysis and model structure have been used to analyze the data.
Main Findings: Results showed that the formed teacher’s innovative space brings a future specialist to the understanding that the quality of life depends on the laborious work on one’s own spirituality, morality and worldview. The future specialist gets experience of professional activity on the basis of universal humane values, which is the main result of the modeled innovative culture in the pedagogical space.
Applications: This research can be used by teachers, the education system and graduate students.
Novelty/Originality: For the first time, modelling the innovation process of teachers has been studied.
STATE POLICY IN DOMESTIC COMPUTING TECHNOLOGY DEVELOPMENT AT THE XX-XXI CENTURIES
Authors: Bodrova Elena V. , Kalinov Viacheslav V. , Kashkin Evgeny V. 
Published: July 2019

Purpose: The aim of the study is to investigate the state policy in domestic computing technology development at the turn of the XX-XXI centuries.
Methodology: The methodological basis of the study was the principles of historicism, objectivity and reliability.
Main Findings: In a number of industry organizations, with the direct participation and under the guidance of the department members, unique automated systems are developed. Hence, the country needs to restructure and modernize its industrial potential, the dialogue between authorities and leading scientists, the training of highly qualified specialists in the field of engineering, etc.
Applications: The research findings can be used by universities, cultural organizations, technology-media institutes and by graduate students in social sciences.
Novelty/Originality: This paper studied Russia’s participation in the international division of labor. Russia’s entry into the global information community required the consideration of international standards during the creation of systems, which needed academic science support.
Seaweed extract of Gracilaria verrucosa as an antibacterial and treatment against Vibrio harveyi infection of Litopenaeus vannamei
Authors: Rudi Mad , Sukenda Sukenda , Wahjuningrum Dinamella , Pasaribu Wesly , Hidayatullah Dendi 
Published: July 2019

ABSTRACTThe objectives of this study were to investigate the antibacterial activity of G. verrucosa extract in test inhibitory zone with different concentrations (500, 1000, 1500, and 2000 mg/L) and to examine G. verrucosa extract with different dosage (0.5, 1.0, 1.5, 2.0 g/kg) in feed on immune responses (total hemocytes count, phagocytic activity, phenoloxidase activity, respiratory burst) and survival rate in the Litopenaeus vannamei against the pathogenic Vibrio harveyi. Pacific white shrimp with an initial body weight of 5.25±0.55 g was reared in the aquarium (60×30×30 cm3) with a density of 10 shrimp/aquarium. Pacific white shrimp had been fed three times a day as much as 3% in at satiation for 14 days after challenged with V. harveyi. The first results of the inhibitory test showed that all the concentration of G. verrucosa extract was able to inhibit the growth of V. harveyi and the second result showed that the extract of G. verrucosa can increase the immune responses of shrimp. In the result of survival showed that shrimp fed with 0.5, 1.0, 1.5, and 2.0 g/kg has 80, 73, 70, and 70%, respectively. In conclusion, the seaweed extract of G. verrucosa has antibacterial activity and can induce the immune responses and resistance of Pacific white shrimp against V. harveyi infection.Keywords: Gracilaria verrucosa, seaweed, Vibrio harveyi, vibriosis, Litopenaeus vannamei ABSTRAKTujuan dari penelitian ini adalah untuk menguji aktivitas antibakteri ekstrak G. verrucosa dalam uji zona hambat dengan konsentrasi yang berbeda (yaitu 500, 1000, 1500, dan 2000 mg/L) dan studi perlakuan pengobatan untuk menguji ekstrak G. verrucosa pada pakan dengan dosis yang berbeda (yaitu 0,5; 1,0; 1,5; dan 2,0 g/kg) pada respons imun (yaitu jumlah total hemosit, aktivitas fagositik, aktivitas fenoloksidase, respiratory burst) dan tingkat kelangsungan hidup pada udang vaname terhadap bakteri patogen Vibrio harveyi. Udang vaname dengan berat badan awal 5,25 ± 0,55 g dipelihara di akuarium (60 × 30 × 30 cm3) dengan kepadatan 10 udang/akuarium. Udang vaname pasifik diberi makan tiga kali sehari 3% at satiation selama 14 hari setelah di uji tantang V. harveyi. Hasil pertama dari uji zona hambat menunjukkan bahwa semua konsentrasi ekstrak G. verrucosa mampu menghambat pertumbuhan V. harveyi dan hasil kedua menunjukkan bahwa pemberian ektrak G. verrucosa dapat meningkatkan respon imun udang. Hasil tingkat kelangsungan hidup menunjukkan bahwa perlakuan pakan udang dengan dosis 0,5; 1,0; 1,5; dan 2,0 g/kg memiliki tingkat kelangsungan hidup masing-masing 80, 73, 70, dan 70%. Kesimpulannya, ekstrak rumput laut G. verrucosa memiliki aktivitas antibakteri dan dapat menginduksi respons imun & ketahanan udang terhadap infeksi V. harveyi.Kata kunci: Gracilaria verrucosa, rumput laut, Vibrio harveyi, vibriosis, udang vaname
Using Projects-Based Learning in Improving Students' Critical Thinking Skills to Recycle Waste Cooking Oil
Authors: Andalas Putri Indah Ningtyas , Fadiawati Noor , Syamsuri M. Mahfudz Fauzi 
Published: July 2019

This study aims to describe the effectiveness of project-based learning in improving students' critical thinking skills. The research design used was the matching only pretest and posttest control group. The population in this study were all students of class XI MIPA, one of the high schools in Bandarlampung. The research sample was students of class XI MIPA 6 and XI MIPA 4. The data analysis technique used is the non parametric statistical test using U Man Whitney. The results of the study showed that the average posttest of critical thinking skills in the experimental class was greater than in the control class. the average n-gain in the experimental class is medium and low in the control class, indicating that project-based learning is effective in improving students' critical thinking skills. Keywords: critical thinking skills, waste cooking oil, project-based learning
Verifikasi Metode Analisis TBC (p-tert butylcatechol) pada Air Limbah Industri dari Proses Polimerisasi
Authors: Yanti Ika 
Published: July 2019

Verifikasi metode analisis TBC (P-Tert Butylcatechol) dalam air limbah menggunakan Spektrofotometer UV-Vis dengan acuan ASTM D 1157-59 telah dilakukan. Verifikasi metode dilakukan untuk membuktikan bahwa metode yang digunakan dapat dipercaya dan dapat dipertanggungjawabakan. Parameter dari verifikasi metode berupa linieritas, presisi, akurasi, dan limit deteksi. Hasil verifikasi metode TBC dalam air limbah industri telah memenuhi syarat dengan hasil uji linieritas sebesar 0,99999~1, uji akurasi standar 10 ppm; 15 ppm; dan 20 ppm sebesar 104,34%; 101,36%; 98,16%, hasil presisi standar 10 ppm; 15 ppm; dan 20 ppm sebesar 0,12903; 0,08430; 0,08429, uji limit deteksi sebesar 0,09447, dan pemantauan konsentrasi sampel air limbah masih berada di bawah ambang batas dengan rata-rata konsentrasi sampel IH-7004 sebesar 3,23 ppm dan sampel S-8503 sebesar 2,28 ppm hasilnya menunjukkan sudah berada di bawah nilai ambang batas yang telah ditentukan yaitu 16 ppm.
PROFIL KOMPETENSI SOSIAL GURU-GURU DI LINGKUNGAN YAYASAN TAMAN PENDIDIKAN DAN SOSIAL NAHDLATUL ULAMA KHADIJAH DAN PENGARUHNYA TERHADAP KEPEKAAN SOSIAL SD KHADIJAH SURABAYA
Authors: Shofiyah Mufidatus Shofiyah 
Published: July 2019

Guru sebagai pendidik mempunyai fungsi untuk membantu siswa berkembang sebagai manusia yang lebih utuh dan penuh. Guru bukan hanya membantu mengembangkan pikiran atau intelektualitas siswa, tetapi juga perkembangan emosi dan kepekaan sosial siswa. Dengan demikian, pendidikan menjadi lebih holistik, lebih menyeluruh, menyangkut seluruh unsur dan nilai kemanusiaan. Fenomena yang sering terjadi saat ini banyak terjadi kekerasan antar siswa, kita saksikan di televisi anak-anak SD menjadi korban kekerasan sesama temannya, siswa tidak disiplin, bersikap tidak sopan terhadap teman, guru dan orang tua, berbicara kotor dengan teman dan tidak tekun dalam beribadah. Tawuran pelajar terjadi dimana-mana dan banyak sekali penyalahgunaan narkoba yang dilakukan oleh pelajar. Hal itu merupakan bukti ketidakberhasilan sekolah untuk membentuk siswa menjadi manusia pembelajar.
Tujuan penelitian ini antara lain; (1) untuk mendiskripsikan tentang profil kompetensi sosial guru-guru SD di lingkungan Yayasan Taman Pendidikan dan Sosial Nahdlatul Ulama (YTPS-NU) Khadijah Surabaya, (2) mendiskripsikan tentang kepekaan sosial siswa SD di lingkungan YTPS-NU Khadijah Surabaya dan (3) mendiskripsikan tentang pengaruh kompetensi sosial guru-guru terhadap kepekaan sosial siswa SD di lingkungan Yayasan Khadijah.
Metode dalam penelitian ini adalah deskriptif kuantitatif, jenis penelitian ini adalah non-eksperimen. Populasi dalam penelitian ini adalah seluruh guru dan siswa kelas III, IV dan V di tiga sekolah YTPS-NU Khadijah Surabaya yang mana jumlah populasi guru 69 dan populasi siswa 692. Jumlah sampel guru dalam penelitian ini 60, dan sampel siswa sejumlah 360 siswa. Teknik pengumpulan data dalam penelitian ini menggunakan angket. Dikarenakan sampel dalam penelitian ini ada 3 sekolah, maka analisis dalam penelitian ini menggunakan analisis inferensial, yang meliputi uji normalitas, uji homogenitas, dan analisis variance.