bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between sleep‐disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction
Authors: Suzuki Satoshi , Yoshihisa Akiomi , Sato Yu , Watanabe Shunsuke , Yokokawa Tetsuro , Sato Takamasa , Oikawa Masayoshi , Kobayashi Atsushi , Yamaki Takayoshi , Kunii Hiroyuki , Nakazato Kazuhiko , Suzuki Hitoshi , Saitoh Shu‐ichi , Ishida Takafumi , Takeishi Yasuchika 
Published: February 2018

AbstractAimsSleep‐disordered breathing (SDB) is associated with arterial stiffness, which may be one of the factors that lead to heart failure (HF). We examined the relationship between pulse wave velocity (PWV) and SDB in patients who have HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).Methods and resultsWe measured the apnoea–hypopnoea index (AHI) by polysomnography, echocardiographic parameters, and PWV in 221 HF patients. Age, blood pressure, and PWV were higher in HFpEF (ejection fraction > 50%, n = 70) patients than in HFrEF (ejection fraction < 50%, n = 151) patients. All HF patients were divided into three groups according to AHI: none‐to‐mild SDB group (AHI < 15 times/h, n = 77), moderate SDB group (15 < AHI < 30 times/h, n = 59), and severe SDB group (AHI > 30 times/h, n = 85). Although blood pressure and echocardiographic parameters did not differ among the three groups, PWV was significantly higher in the severe SDB group than in the none‐to‐mild and moderate SDB groups (P = 0.002). When the HFrEF and HFpEF patients were analysed separately, PWV was significantly higher in the severe SDB group than in the none‐to‐mild and moderate SDB groups in patients with HFpEF (P = 0.002), but not in those with HFrEF (P = 0.068). In the multiple regression analysis to determine PWV, the presence of severe SDB was found to be an independent predictor of high PWV in HFpEF (β = 0.234, P = 0.005), but not in HFrEF patients.ConclusionsSevere SDB is associated with elevated arterial stiffness and may be related to the pathophysiology of HF, especially in HFpEF patients.
Chloroquine‐induced cardiomyopathy: a reversible cause of heart failure
Authors: Yogasundaram Haran , Hung Whitney , Paterson Ian D. , Sergi Consolato , Oudit Gavin Y. 
Published: February 2018

AbstractChloroquine (CQ) and hydroxychloroquine (HCQ) are anti‐rheumatic medications frequently used in the treatment of connective tissue disorders. We present the case of a 45‐year‐old woman with CQ‐induced cardiomyopathy leading to severe heart failure. Electrocardiographic abnormalities included bifascicular block, while structural disease consisted of severe biventricular and biatrial hypertrophy. Appropriate diagnosis via endomyocardial biopsy led to cessation of CQ and subsequent dramatic improvement in symptoms and structural heart disease. Cardiac toxicity is an under‐recognized adverse effect of CQ/HCQ leading to cardiomyopathy with concentric hypertrophy and conduction abnormalities, with the potential for significant morbidity and mortality. Predisposing factors for CQ/HCQ‐induced cardiomyopathy have been proposed. CQ/HCQ cardiomyopathy is a phenocopy of Fabry disease, and α‐galactosidase A polymorphism may account for some heterogeneity of disease presentation.
Intermittent energy restriction for weight loss: Spontaneous reduction of energy intake on unrestricted days
Authors: Harvey Jennifer , Howell Anthony , Morris Julie , Harvie Michelle 
Published: February 2018

AbstractThere is increasing interest for the use of intermittent energy restriction (IER) in weight management. However, there are concerns that IER could result in ‘rebound’ overconsumption of energy on unrestricted days. We studied self‐reported food records from participants in two trials of IER versus continuous energy restriction (Study 1; 44 women on IER for 6 months and Study 2; 72 women on two types of IER for 4 months). Energy intake was assessed on restricted and unrestricted days immediately before and after restricted days and on other unrestricted days. We assessed consistency of days of the week chosen as restricted days, and whether this was associated with greater weight loss. Reported energy intake was reduced on unrestricted days in Study 1 and 2 and was 19% lower compared with the allocated isoenergetic diet, and respectively 21% and 29% lower than their baseline reported daily intakes. Energy intake appeared to be similarly reduced the day immediately before and after restricted days and on other unrestricted days. Seventy percent of women in Study 1 and 79% in Study 2 undertook consistent days of restriction each week (>50% of restricted days on the same 2 days each week). When studies were combined percentage weight loss at 3 months was −5.8 (−6.7 to −4.7) % in the consistent group and −7.4 (−8.7 to −6.2) % in the non‐consistent group (p = .09). Food records from patients undertaking IER suggest a spontaneous reduction in energy intake below their baseline reported intakes and the prescribed isoenergetic diet during all unrestricted days including the days immediately before and after restricted days which contributes to the weight loss success with these diets. Consistency of restricted days was not associated with weight loss success. These findings need to be confirmed in larger groups of patients ideally using objective measures of energy balance.
Origin and influence of a Late Mesozoic multistage I‐ and A‐type granitic complex in northern Fujian Province, South China
Authors: Wang Kai‐Xing , Huang Hui , Liu Xiao‐Dong , Pan Jia‐Yong 
Published: February 2018

The Late Mesozoic Pucheng granitic complex in northern Fujian Province is composed of the Chengbu and Shipi peralkaline A‐type granitoids, the Pucheng A‐type granitoid, and the Yongxing I‐type granitoid. The Chengbu and Shipi peralkaline granitoids were dated at 160 and 130 Ma, respectively, and are explained by the melting of meta‐igneous rocks with TDM2 of 1.70 Ga and 2.01 to 2.05 Ga. The Pucheng A‐type granitoid was emplaced at 110 and 102 Ma and is divided into two groups. Group 1 comprises the extremely felsic A‐type granite (SiO2 > 73 wt.%), high FeOT/MgO (>16), and low Ga/Al ratios and Zr + Nb + Ce + Y content. Group 2 contains a less‐evolved A‐type granite with high Zr + Nb + Ce + Y content. Both groups can be explained by dehydration melting of meta‐igneous rocks at low pressure. The diversity between the two groups was caused by different physicochemical environments. The Yongxing I‐type granite, which is abundant in mafic microgranular enclaves, was emplaced at 106 ± 1 Ma. It can be explained by the mingling of mantle‐derived and crustal‐derived magmas. Our data along with previously published data demonstrate that the northern Fujian Province was under an extensional environment from 160 to 100 Ma. This was caused by the NW‐trending subduction of the palaeo‐Pacific Plate. The Jurassic peralkaline granitoids were probably generated in a rift environment as a result of the reactivation of pre‐existing faults caused by the initial subduction of the palaeo‐Pacific Plate. The Early Cretaceous peralkaline granitoids may represent a rift environment as a tectonic response from low‐angle subduction to an increasing subduction dip angle. The 100 Ma granitoids derive from an intraplate extensional environment caused by the roll‐back of the palaeo‐Pacific Plate.
Enigmatic nodule‐bearing rocks in the mafic to ultramafic Diana Mills pluton, Piedmont Province, Virginia
Authors: Owens Brent E. , Telep Elizabeth S. , Garry W. Brent 
Published: February 2018

The Silurian Diana Mills pluton is a metamorphosed mafic–ultramafic body in the Piedmont Province of Virginia. Major rock types in the pluton include metadiorite and chlorite‐amphibole rock, with lesser amounts of hornblendite. However, the most visually striking rocks, found at 4 locations, consist of tan‐weathering nodules in a dark green matrix. The purpose of this study was to investigate the origin of these nodular rocks. All rocks show evidence of greenschist‐facies metamorphism, but relict igneous textures are preserved locally. Apart from the nodules, Ca‐amphibole is ubiquitous in all rock types. Nodules are dominated by serpentine or talc (+magnetite ± chromite), and many show a thin (≤5 mm) radially oriented shell of serpentine against adjacent matrix. The nodules are ultramafic (Mg# ~80–90, up to7,563 ppm Cr, up to 2,038 ppm Ni), and their normative mineralogy is dominated by olivine and orthopyroxene. Thus, they represent metamorphosed harzburgites and pyroxenites. Matrix minerals are dominantly amphibole + chlorite, along with variable amounts of talc + magnetite. Some matrix samples are chlorite‐rich, probably reflecting metasomatic reaction with nodules (i.e., they are small‐scale “blackwalls”). Matrix samples are also ultramafic (high Mg#, Cr, and Ni). The matrix of the nodule‐bearing outcrops is essentially the same as other chlorite‐amphibole rocks elsewhere in the pluton. We consider these rocks to represent emplacement of an original hornblende peridotite crystal mush (a mixture of crystals and hydrous melt), which locally carried harzburgitic nodules. The nodules most likely represent the earliest‐formed cumulates from the Diana Mills parent magma.
Astrocytes sustain long‐term productive HIV‐1 infection without establishment of reactivable viral latency
Authors: Barat Corinne , Proust Alizé , Deshiere Alexandre , Leboeuf Mathieu , Drouin Jean , Tremblay Michel J. 
Published: February 2018

AbstractThe “shock and kill” HIV‐1 cure strategy proposes eradication of stable cellular reservoirs by clinical treatment with latency‐reversing agents (LRAs). Although resting CD4+ T cells latently infected with HIV‐1 constitute the main reservoir that is targeted by these approaches, their consequences on other reservoirs such as the central nervous system are still unknown and should be taken into consideration. We performed experiments aimed at defining the possible role of astrocytes in HIV‐1 persistence in the brain and the effect of LRA treatments on this viral sanctuary. We first demonstrate that the diminished HIV‐1 production in a proliferating astrocyte culture is due to a reduced proliferative capacity of virus‐infected cells compared with uninfected astrocytes. In contrast, infection of non‐proliferating astrocytes led to a robust HIV‐1 infection that was sustained for over 60 days. To identify astrocytes latently infected with HIV‐1, we designed a new dual‐color reporter virus called NL4.3 eGFP‐IRES‐Crimson that is fully infectious and encodes for all viral proteins. Although we detected a small fraction of astrocytes carrying silent HIV‐1 proviruses, we did not observe any reactivation using various LRAs and even strong inducers such as tumor necrosis factor, thus suggesting that these proviruses were either not transcriptionally competent or in a state of deep latency. Our findings imply that astrocytes might not constitute a latent reservoir per se but that relentless virus production by this brain cell population could contribute to the neurological disorders seen in HIV‐1‐infected persons subjected to combination antiretroviral therapy.
The impact of child welfare legislation on domestic violence‐related homicide rates
Authors: Dasgupta Kabir , Pacheco Gail 
Published: February 2018

SummaryState‐specific statutes providing legal consequences for perpetrating domestic violence in the presence of a child have been enacted across the United States between 1996 and 2012. This paper examines the impact of this child welfare legislation, using a difference‐in‐differences approach. We find a significant drop in domestic violence‐related homicide rates, when considering a wide range of victim–offender relationships. However, this result does not hold for marital homicides, suggesting that for this subpopulation, the risk of reprisal and consequent reduction in reporting may be counterbalancing the hypothesized deterrent impacts of the legislation.
The “ripple effect”: Health and community perceptions of the Indigenous Marathon Program on Thursday Island in the Torres Strait, Australia
Authors: Macniven Rona , Plater Suzanne , Canuto Karla , Dickson Michelle , Gwynn Josephine , Bauman Adrian , Richards Justin 
Published: February 2018

AbstractIssue addressedPhysical inactivity is a key health risk among Aboriginal and Torres Strait Islander (Indigenous) Australians. We examined perceptions of the Indigenous Marathon Program (IMP) in a remote Torres Strait island community.MethodsSemi‐structured interviews with community and program stakeholders (n = 18; 14 Indigenous) examined barriers and enablers to running and the influence of the IMP on the community. A questionnaire asked 104 running event participants (n = 42 Indigenous) about their physical activity behaviours, running motivation and perceptions of program impact. Qualitative data were analysed using thematic content analysis, and quantitative data were analysed using descriptive statistics.ResultsInterviews revealed six main themes: community readiness, changing social norms to adopt healthy lifestyles, importance of social support, program appeal to hard‐to‐reach population groups, program sustainability and initiation of broader healthy lifestyle ripple effects beyond running. Barriers to running in the community were personal (cultural attitudes; shyness) and environmental (infrastructure; weather; dogs). Enablers reflected potential strategies to overcome described barriers. Indigenous questionnaire respondents were more likely to report being inspired to run by IMP runners than non‐Indigenous respondents.ConclusionsPositive “ripple” effects of the IMP on running and broader health were described to have occurred through local role modelling of healthy lifestyles by IMP runners that reduced levels of “shame” and embarrassment, a common barrier to physical activity among Indigenous Australians. A high initial level of community readiness for behaviour change was also reported.So what?Strategies to overcome this “shame” factor and community readiness measurement should be incorporated into the design of future Indigenous physical activity programs.
Predictive Models in Ecotoxicology: Bridging the Gap Between Scientific Progress and Regulatory Applicability
Authors: Focks Andreas , Grisoni Francesca , Barsi Alpar , Vighi Marco 
Published: February 2018

Abstract

This special series is the outcome of the session “Predictive models in ecotoxicology: Bridging the gap between scientific progress and regulatory applicability,” held at the 27th SETAC Europe annual meeting (Brussels, May 2017). In this foreword the rationale behind the special series, the reasons for proposing it, and its objectives are described briefly. Integr Environ Assess Manag 2018;14:601–603. © 2018 SETAC
Spatiotemporal Patterns on a Ring Network of Oscillatory Electrochemical Reaction with Negative Global Feedback
Authors: Sebek Michael , Kiss István Z. 
Published: February 2018

AbstractThe formation of spatiotemporal patterns in chemical systems can often be attributed to local and global interactions with the nonlinear kinetics, e. g., due to diffusion or an external constraint, respectively. We investigate the dynamics of an oscillatory chemical reaction on a ring of discrete elements, where the positive local coupling and negative global feedback can be varied independently to observe the emerging spatiotemporal patterns. With local coupling, the oscillations exhibit nearly in‐phase synchronization. When increasing the global negative feedback, a transition is seen from nearly sinusoidal phase profile oscillations through rotating and standing waves to amplitude death behavior. The experimental studies are interpreted with a kinetic model of nickel electrodissolution. The results demonstrate the presence of rich spatiotemporal patterns that can be obtained in a network with positive local and negative global interactions.
Enhanced brain image retrieval using carrier frequency offset compensated orthogonal frequency division multiplexing for telemedicine applications
Authors: Chitra S. , Kumaratharan N. , Ramesh S. 
Published: February 2018

AbstractWireless technology plays a vital role in the Electronic health (e‐health) applications such as telemedicine and remote patient monitoring. One of the major challenges of telemedicine applications is ensuring adequate quality of service and realizing precise diagnosis. Telemedicine employs image fusion to enhance the quality of medical image for better diagnosis. However, the transmission of medical image needs high data rate and bandwidth. Due to the robustness to multipath fading, high data rate transmission capability, high flexibility, high bandwidth efficiency, and easy implementation using fast Fourier transform, an orthogonal frequency division multiplexing (OFDM) is the suitable technique for medical image transmission in telemedicine applications This paper is focused on improving the quality of the fused brain image transmission over OFDM based telemedicine service using comb type pilot based carrier frequency offset compensation. The simulation results show that the proposed method offers better performance in terms of mean squared error, Euclidean distance, peak signal to noise ratio, bit error rate, carrier to interference ratio, and computational complexity.
An improved strategy for skin lesion detection and classification using uniform segmentation and feature selection based approach
Authors: Nasir Muhammad , Attique Khan Muhammad , Sharif Muhammad , Lali Ikram Ullah , Saba Tanzila , Iqbal Tassawar 
Published: February 2018

AbstractMelanoma is the deadliest type of skin cancer with highest mortality rate. However, the annihilation in early stage implies a high survival rate therefore, it demands early diagnosis. The accustomed diagnosis methods are costly and cumbersome due to the involvement of experienced experts as well as the requirements for highly equipped environment. The recent advancements in computerized solutions for these diagnoses are highly promising with improved accuracy and efficiency. In this article, we proposed a method for the classification of melanoma and benign skin lesions. Our approach integrates preprocessing, lesion segmentation, features extraction, features selection, and classification. Preprocessing is executed in the context of hair removal by DullRazor, whereas lesion texture and color information are utilized to enhance the lesion contrast. In lesion segmentation, a hybrid technique has been implemented and results are fused using additive law of probability. Serial based method is applied subsequently that extracts and fuses the traits such as color, texture, and HOG (shape). The fused features are selected afterwards by implementing a novel Boltzman Entropy method. Finally, the selected features are classified by Support Vector Machine. The proposed method is evaluated on publically available data set PH2. Our approach has provided promising results of sensitivity 97.7%, specificity 96.7%, accuracy 97.5%, and F‐score 97.5%, which are significantly better than the results of existing methods available on the same data set. The proposed method detects and classifies melanoma significantly good as compared to existing methods.
Geographical offender profiling: Dragnet's applicability on a Brazilian sample
Authors: Lino Denis , Calado Bruna , Belchior Danielly , Cruz Mayara , Lobato Aline 
Published: February 2018

AbstractEven though geographical offender profiling is already widely used and researched in countries such as England, Canada, and United States, it is still severely overlooked in Brazil, as there are no researches on the subject using a Brazilian sample. Therefore, the present paper aims to start filling this gap by analysing the applicability of the geographical offender profiling and Dragnet on a sample of Brazilian serial killers. In order to achieve this objective, the authors collected data through police records on 15 serial killers that were active between June 2009 and June 2015, in the city of Campina Grande, Paraíba, Brazil. As a result, the circle hypothesis was confirmed, considering that 66.7% of the sample fell into the marauder category. Interestingly, the Dragnet's result accurately informed the area that contained the offender's base in the same cases in which the offender acted according to the marauder model. Also, other important correlations were found such as the influence of age, intelligence, resourcefulness, and method of approach on the distance travelled to commit a murder. Those results show that the geographical offender profiling can be effectively applied in Brazil and thus is a valid investigative tool to aid police officers in serial crimes investigations.
Electromagnetic pulse response of planar screens
Authors: Araneo Rodolfo , Lovat Giampiero , Burghignoli Paolo , Celozzi Salvatore 
Published: February 2018

AbstractA general numerical method for calculating the time‐domain characteristics of the electromagnetic field generated by a pulsed dipole in the presence of a planar multilayered screen is presented. The method involves the efficient evaluation of classical Sommerfeld integrals and an inverse Fourier transform to recover the time‐domain field from the frequency‐domain field. For sufficiently thin screens with highly conductive properties, an analytical method, based on a modified Cagniard–de Hoop approach, is also presented to validate the results.
Serum, salivary, and tissue levels of plasminogen in familial Mediterranean fever, amyloidosis, and chronic periodontitis
Authors: Fentoğlu Özlem , Dinç Gözde , Doğru Atalay , Karahan Nermin , İlhan İlter , Kırzıoğlu F. Yeşim , Şentürk Mehmet Fatih , Orhan Hikmet 
Published: February 2018

AbstractBackgroundThere are no published studies regarding the role of the plasminogen (PLG) system in familial Mediterranean fever (FMF), FMF‐associated secondary amyloidosis, or chronic periodontitis (CP), although recent limited data have focused on the association between FMF and chronic periodontitis. Therefore, the aim of this study was to evaluate the serum, salivary, and gingival tissue levels of PLG in patients with CP, FMF, and amyloidosis.MethodsThe study population included 122 patients with FMF (only FMF, and FMF and amyloidosis and 128 individuals who were systemically healthy controls. Blood and salivary samples were obtained from the cases and controls, and clinical periodontal parameters were recorded. Serum and salivary PLG levels were assessed. The gingival tissue samples of the case and control groups were analyzed histopathologically and immunohistochemically for amyloid deposition and PLG.ResultsThe amyloidosis group had significantly more severe clinical periodontal parameters than those of the FMF and systemically healthy groups (P < 0.05). Salivary levels of PLG were significantly higher in the FMF and amyloidosis groups compared with those in the control group (P < 0.001). The FMF with periodontitis and amyloidosis with periodontitis groups had higher salivary PLG levels compared with those in the CP group. Serum and salivary PLG levels were significantly associated with the clinical periodontal parameters in the FMF group. The amyloidosis cases had hyperplasia, severe inflammation, and activation of the gingiva.ConclusionThe PLG system could play an important role in inflammatory diseases, such as chronic periodontitis, FMF, and FMF‐associated secondary amyloidosis.