bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Authors: Xu Xiaxia , Chini Mattia , Bitzenhofer Sebastian H. , Hanganu-Opatz Ileana L. 
Published: January 2019

Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 (DISC1), which represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. Mice with whole-brain DISC1 knock-down show impaired prefrontal–hippocampal function and cognitive abilities throughout development and at adulthood, especially when combined with early environmental stressors, such as maternal immune activation (MIA). However, the contribution of abnormal DISC1-driven maturation of either prefrontal cortex (PFC) or hippocampus (HP) to these deficits is still unknown. Here, we usein uteroelectroporation to restrict the DISC1 knock-down to prefrontal layer II/III pyramidal neurons during perinatal development and expose these mice to MIA as an environmental stressor (dual-hit GPFCE mice, both sexes). Combiningin vivoelectrophysiology and neuroanatomy with behavioral testing, we show that GPFCE mice at neonatal age have abnormal patterns of oscillatory activity and firing in PFC, but not HP. Abnormal firing rates in PFC of GPFCE mice relate to sparser dendritic arborization and lower spine density. Moreover, the long-range coupling within prefrontal–hippocampal networks is decreased at this age. The transient prefrontal DISC1 knock-down was sufficient to permanently perturb the prefrontal–hippocampal communication and caused poorer recognition memory performance at pre-juvenile age. Thus, developmental dysfunction of prefrontal circuitry causes long-lasting disturbances related to mental illness.SIGNIFICANCE STATEMENTHypofrontality is considered a main cause of cognitive deficits in mental disorders, yet the underlying mechanisms are still largely unknown. During development, long before the emergence of disease symptoms, the functional coupling within the prefrontal–hippocampal network, which is the core brain circuit involved in cognitive processing, is reduced. To assess to which extent impaired prefrontal development contributes to the early dysfunction, immune-challenged mice with transient DISC1 knock-down confined to PFC were investigated in their prefrontal–hippocampal communication throughout development byin vivoelectrophysiology and behavioral testing. We show that perturbing developmental processes of prefrontal layer II/III pyramidal neurons is sufficient to diminish prefrontal–hippocampal coupling and decrease the cognitive performance throughout development.
Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking
Authors: Pardo-Garcia Thibaut R. , Garcia-Keller Constanza , Penaloza Tiffany , Richie Christopher T. , Pickel James , Hope Bruce T. , Harvey Brandon K. , Kalivas Peter W. , Heinsbroek Jasper A. 
Published: January 2019

Outputs from the nucleus accumbens (NAc) include projections to the ventral pallidum and the ventral tegmental area and subtantia nigra in the ventral mesencephalon. The medium spiny neurons (MSN) that give rise to these pathways are GABAergic and consist of two populations of equal number that are segregated by differentially expressed proteins, including D1- and D2-dopamine receptors. Afferents to the ventral pallidum arise from both D1- and D2-MSNs, whereas the ventral mesencephalon is selectively innervated by D1-MSN. To determine the extent of collateralization of D1-MSN to these axon terminal fields we used retrograde labeling in transgenic mice expressing tdTomato selectively in D1-MSN, and found that a large majority of D1-MSN in either the shell or core subcompartments of the accumbens collateralized to both output structures. Approximately 70% of D1-MSNs projecting to the ventral pallidum collateralized to the ventral mesencephalon, whereas >90% of mesencephalic D1-MSN afferents collateralized to the ventral pallidum. In contrast, <10% of dorsal striatal D1-MSNs collateralized to both the globus pallidus and ventral mesencephalon. D1-MSN activation is required for conditioned cues to induce cocaine seeking. To determine which D1-MSN projection mediates cued cocaine seeking, we selectively transfected D1-MSNs in transgenic rats with an inhibitory Gi-coupled DREADD. Activation of the transfected Gi-DREADD with clozapine-N-oxide administered into the ventral pallidum, but not into the ventral mesencephalon, blocked cue-induced cocaine seeking. These data show that, although accumbens D1-MSNs largely collateralize to both the ventral pallidum and ventral mesencephalon, only D1-MSN innervation of the ventral pallidum is necessary for cue-induced cocaine seeking.SIGNIFICANCE STATEMENTActivity in D1 dopamine receptor-expressing neurons in the NAc is required for rodents to respond to cocaine-conditioned cues and relapse to drug seeking behaviors. The D1-expressing neurons project to both the ventral pallidum and ventral mesencephalon, and we found that a majority of the neurons that innervate the ventral pallidum also collateralize to the ventral mesencephalon. However, despite innervating both structures, only D1 innervation of the ventral pallidum mediates cue-induced cocaine seeking.
High Level of Conservation of Mitochondrial RNA Editing Sites Among Four Populus Species
Authors: Brenner Wolfram Georg , Mader Malte , Müller Niels Andreas , Hoenicka Hans , Schroeder Hilke , Zorn Ingo , Fladung Matthias , Kersten Birgit 
Published: January 2019

Abstract
RNA editing occurs in the endosymbiont organelles of higher plants as C-to-U conversions of defined nucleotides. The availability of large quantities of RNA sequencing data makes it possible to identify RNA editing sites and to quantify their editing extent. We have investigated RNA editing in 34 protein-coding mitochondrial transcripts of four Populus species, a genus noteworthy for its remarkably small number of RNA editing sites compared to other angiosperms. 27 of these transcripts were subject to RNA editing in at least one species. In total, 355 RNA editing sites were identified with high confidence, their editing extents ranging from 10 to 100%. The most heavily edited transcripts were ccmB with the highest density of RNA editing sites (53.7 sites / kb) and ccmFn with the highest number of sites (39 sites). Most of the editing events are at position 1 or 2 of the codons, usually altering the encoded amino acid, and are highly conserved among the species, also with regard to their editing extent. However, one SNP was found in the newly sequenced and annotated mitochondrial genome of P. alba resulting in the loss of an RNA editing site compared to P. tremula and P. davidiana. This SNP causes a C-to-T transition and an amino acid exchange from Ser to Phe, highlighting the widely discussed role of RNA editing in compensating mutations.
TATA KELOLA PEMUKIMAN NELAYAN DI WILAYAH PERKOTAAN PESISIR UTARA JAKARTA
Authors: Maharani Hertria , Nurlaili Nurlaili 
Published: January 2019

Pemukiman nelayan di kawasan perkotaan belum banyak diperhatikan oleh pemerintah. Seharusnya sebagai bagian dari perencanaan kota, pemukiman nelayan mempunyaI urgensi yang sama untuk diatur sehingga dapat dikelola dengan baik. Makalah ini mempunyai tiga tujuan utama, yaitu: 1) Mengidentifikasi kondisi eksisting kawasan pemukiman nelayan; 2) Mengidentifikasi hambatan perencanaan pemukiman nelayan di perkotaan; dan 3) menganalisis peran perencanaan kota pada tatakelola pemukiman nelayan. Observasi hanya dilakukan di pantai utara Teluk Jakarta (Kamal Muara) terkait kondisi eksisting dan hambatan perencanaan pemukiman nelayan. Data primer diperoleh dari hasil wawancara informan kunci dengan menggunakan bantuan topik data. Hasil penelitian menunjukkan bahwa kondisi pemukiman nelayan masih jauh dari kondisi ideal, yang mulai dari sanitasi, desain pemukiman, drainase dan sebagainya. Sedangkan terdapat 3 stakeholder yang bertanggungjawab atas kesulitan pengaturan pemukiman nelayan yaitu masyarakat nelayan, pemerintah dan instansi swasta termasuk pengembang dan perbankan. Ketiga elemen stakeholder tersebut harus bersamasama melakukan upaya untuk perbaikan tata kelola pemukiman nelayan dengan tanpa melupakan pemahaman bahwa nelayan tidak dapat dipisahkan dari laut dan tepi pantai sebagai tempat bekerja, komunitas dan budaya.Title: Fisherman Settlement Management in Urban Region of Northern-Coast of Jakarta Fisherman settlements in urban areas have received less attention by the government. As a part of urban planning, fisherman settlements should have the same urgency to be well governed. This paper has three main objectives: 1) to identify existing conditions of fishermen residential areas; 2) to identify barriers on planning of fisherman settlements in urban area; and 3) to analyze the role of urban planning on fisherman settlements governance. Observation toward existing conditions and the barriers on fisherman settlements planning were only completed in Kamal Muara, the northern coast of Jakarta Bay. Primary data were obtained from key informant interviews using data topic tool. The results show that the conditions of the fisherman settlement is still under ideal level, including its sanitation, settlement design, drainage, etc. There are 3 stakeholders who are responsible for the difficulties in regulating fisherman settlements, they are fishing communities, government and private institutions including developers and commercial banks. These three elements must jointly improve the governance of fisherman settlements under the same perception that fishermen cannot be separated from the sea and coast area as a work place, community and culture.
Spirituality and psycho-organic regulation
Authors: Cvetek Robert , Gostečnik Christian , Pate Tanja , Simonič Barbara , Valenta Tanja , Repič Slavič Tanja 
Published: January 2019

Traumatic experiences are very important for the psycho-organic regulation of an individual. These experiences can very profoundly mark an individual, especially if they happened in childhood. They can be very disruptive and they scream for healing. In this process of healing spirituality plays a crucial role. Religiousness and sacramental life can be an essential regulatory system in the establishment of a functional psycho–organic response and spiritual life.
Luigi Giussani and Catholic Historiography
Authors: Klumpenhouwer Samuel 
Published: January 2019

This essay explores the difficulties of conducting historiographical research from a Catholic view point. It through the life and writings of Luigi Giussani, founder of the movement Communion and Liberation. Three main approaches to history will be explored: the rationalist approach, the Protestant approach, and finally the Orthodox-Catholic approach. The essay argues that only the third approach is sufficient to examine the historical claims about Jesus.
Jakość życia osób starszych uczestniczących w zajęciach uniwersytetu trzeciego wieku
Authors: Talaga Stanisława , Dyrcz Marta , Lubińska-Żądło Bogumiła , Kiełtyka Aleksandra 
Published: January 2019

Jakość życia osób starszych uczestniczących w zajęciach uniwersytetu trzeciego wieku. W związku z zjawiskiem starzenia się społeczeństwa i tworzeniem nowej polityki społecznej powstał nowy kierunek w pedagogice zwany andragogiką, czyli subdyscyplina zajmującą się kształceniem dorosłych. Zadanie kształcenia dorosłych przejęły uniwersytety trzeciego wieku, realizując takie cele jak: edukacja ustawiczna, aktywizacja społeczno-kulturowa, aktywizacja ruchowa oraz szerzenie wśród uczestników gerontologicznej profilaktyki. Celem niniejszej pracy jest porównanie jakości życia osób po 60. roku życia, studiujących na uniwersytecie trzeciego wieku, z osobami nieuczestniczącymi w żadnych zajęciach dla seniorów i bytujących wyłącznie we własnym środowisku domowym. W badaniu zastosowano metodę sondażu diagnostycznego. Jako narzędzie badawcze posłużył kwestionariusz ankiety własnego autorstwa zawierający 22 pytania, Kwestionariusz Oswestry oraz The World Health Organization Quality of Life (WHOQOL) – BREFF.
La definizione di sacramento in pensiero di Pietro Lombardo
Authors: Jeziorski Sławomir 
Published: January 2019

Le Sentenze di Pietro Lombardo influirono molto sul pensiero teologico medievale. Di conseguenza non è priva del significato per la teologia la sua definizione del sacramento, la quale si trova nell’opera principale del autore. Presente articolo è un tentativo di descrivere quella definizione che diede una base per la sistematizzazione e la definizione del settenario dei sacramenti nella Chiesa cattolica. A tale scopo, prima è stato brevemente presentato il contesto storico-culturale del pensiero di Lombardo. Poi, su quello sfondo, è stata presentata la definizione del sacramento nelle Sentenze. Essa è stata sottomessa all’analisi grammatica e successivamente a quella teologica. E questa seconda contiene la descrizione del segno, casualità, somiglianza e forma del sacramento.
Poświęcić swoje życie dla innych. Ofiara Edyty Stein, Laury Vicuñi i nazaretanek z Nowogródka
Authors: Durma Izabela 
Published: January 2019

Celem artykułu było przedstawienie trzech historii wyniesionych na ołtarze kobiet, które poniosły śmierć, ofiarowując swoje życie za innych. Zwrócono jednakże uwagę nie tyle na samą ofiarę, ile jej gotowość. Wzorem takiej postawy niewątpliwie był patriarcha Abraham. Błogosławiona Laura, Święta Edyta i Błogosławione Nazaretanki w trosce o swoich bliskich prosiły na modlitwie o to, aby mogły ponieść cierpienia w określonych intencjach, nie wiedząc, jak miałoby to wyglądać. Kiedy jednak przyszedł czas na wypełnienie obietnicy, wszystkie potwierdziły je czynem.
Duchowa sylwetka alumna Jana Ślęzaka na podstawie notatek rekolekcyjnych z lat 1935–1937
Authors: Rąpała Tomasz 
Published: January 2019

Ksiądz Jan Ślęzak, proboszcz w Ołpinach był człowiekiem, który realizował powołanie w sposób radosny i bardzo ofiarny. Rozpalała go miłość do Boga, a poprzez to do drugiego człowieka. Był księdzem „z powołania” – zgodnie z określeniem, którego wierni używają w odniesieniu do księży, którzy są dla nich, a nie dla siebie.Z Notatek rekolekcyjnych wiemy, w jaki sposób kształtował swe powołanie alumn Jan. Bardzo wyraźnie dostrzegamy jego zaangażowanie w formację ludzką, duchową i intelektualną. To właśnie w Seminarium Duchownym w Tarnowie odnalazł fundament na całe życie. Dlatego też posługa w parafii przynosiła tak wiele owoców.Ksiądz Jan Ślęzak wpisuje się w profil duchowy księdza diecezjalnego, który spala się w posłudze kapłańskiej dla wiernych, ogłaszając zmartwychwstałego Chrystusa. Tym profilem jest bycie dla ludu, bycie z ludem. I to ma najgłębszy sens.
Dual Zariski Topology on Comultiplication Modules
Authors: ÖNEŞ Ortaç 
Published: January 2019

This paper deals
with dual Zariski topology on comultiplication modules. We define a subspace
topology of dual Zariski topology on comultiplication modules and study some
properties of this subspace topology. We prove that XsN is an Artinian topological space if and only if M satisfies
the SN-condition.
PRODUCTION OF URANIUM-MOLYBDENUM ALLOY AS A CANDIDATE FOR NUCLEAR RESEARCH REACTOR FUEL
Authors: Suryaman Ganisa Kurniati , Wildan Muhammad Waziz , Supardjo Supardjo , Agus Susanto Yatno Dwi 
Published: January 2019

PRODUCTION OF URANIUM−MOLYBDENUM ALLOY AS A CANDIDATE FOR NUCLEAR RESEARCH REACTOR FUEL. Research and development on high density uranium for nuclear research reactor fuel is still in progress. Uranium-molybdenum alloy is one of the strongest candidates of nuclear research reactor fuel material. The properties and characteristics of U-Mo alloy is of important consideration for the selction of the fabrication techniques for the production of the fuel. In this work, uranium-molybdenum (U-Mo) alloys with varied molybdenum content have been produced succesfully by arc melting technique. The molybdenum content variations were 7 %wt, 8 %wt, 9 %wt and 10 %wt Mo. The melting process was done 5 times to achieve homogenization. Metallographic micrograph shows the presence of dendritic structure. XRD examination result affirms the presence of 2 phases of γ-U phase and d-U2Mo phase. Microhardness Vickers test shows higher hardness value for Uranium-molybdenum alloy with higher molybdenum content.Keywords: U−Mo alloy, research reactor, fuel.
ÖĞRETMENLERİN POZİTİF PSİKOLOJİK SERMAYE ALGILARI İLE PROBLEM ÇÖZME BECERİLERİNİN İNCELENMESİ
Authors: Anık Sabri , Tösten Rasim 
Published: January 2019

Bu araştırmanın amacı öğretmenlerin
pozitif psikolojik sermaye algıları ile problem çözme becerileri arasındaki ilişkiyi
incelemektir. Araştırma nicel desenli olup ilişkisel tarama modelindedir.
Araştırmanın evrenini 2017-2018 öğretim yılında Şırnak merkezinde bulunan 39
ilkokul, 37 ortaokul ve 13 lisede görev yapan toplam 1161 öğretmen
oluşturmaktadır. Ancak evreni temsil edeceği düşünülen tabakalı örneklem alma
yoluna gidilmiştir. Bu amaçla araştırma 496 öğretmen ile yürütülmüştür.
Araştırma verilerinin toplanmasında iki ölçek kullanılmıştır. Ölçme aracı üç
bölümden oluşmakta olup birinci bölümde öğretmenlerin kişisel bilgilerini
almaya yönelik sorular, ikinci bölümde psikolojik sermaye ölçeği ve üçüncü
bölümde problem çözme becerisi envanteri yer almıştır. Öğretmenlerin pozitif
psikolojik sermaye algılarını ölçmek amacıyla Tösten ve Özgan (2014) tarafından
geliştirilen 6 boyuttan ve 26 maddeden oluşan ‘Pozitif Psikolojik Sermaye
Ölçeği’ ve öğretmenlerin problem çözme becerilerini ölçmek amacıyla Heppner
(1988) tarafından geliştirilen ve Şahin, Şahin ve Heppner (1993) tarafından
Türkçe’ye uyarlanan 6 boyut ve 35 maddeden oluşan problem çözme envanteri
uygulanmıştır. Elde edilen verilerin çözümlenmesinde betimsel (tanımlayıcı)
testlerden, korelasyon testi ve regresyon analizinden yararlanılmıştır.

Araştırma sonucunda,
öğretmenlerin pozitif psikolojik sermaye algılarının yüksek düzeyde olduğu;
problem çözme becerilerinin orta düzeyde olduğu; pozitif psikolojik sermaye
algıları ile problem çözme becerileri arasında orta düzeyde pozitif yönde
ilişkinin olduğu; öğretmenlerde pozitif psikolojik sermayenin problem çözme becerisini
yordamasında modelin anlamlı olduğu ve %10 yordadığı görülmüştür.
Assessment of national vector borne disease control programme in state of Karnataka
Authors: Arali Puneet Kumar , Shanbhag Deepthi N. 
Published: January 2019

ABSTRACTBackground:National vector borne disease control programme(NVBDCP) was launched to control the prevalence of vector borne diseases like malaria, filaria, Japanese encephalitis (JE), Dengue/DHF, chikungunya, lymphatic filariasis and Kala Azar. The present study was done to assess the activities of NVBDCP in state of Karnatakaand to analyze selective qualitative and quantitative indicators related to the activities.Methods:Quantitatively retrospective data was collected from Directorate office Department of Health and Family Welfare, NVBDCP section from April 2016 to March 2017. Qualitatively questionnaire based protocol was made and interviews were conducted with District programme officer, PHC medical officer and grass root level health workers like ANM, ASHA with reference to one each of selected least performing districts and good performing districts in the state. The collected data was analysed by using Microsoft Excel 2010 version.Results:The highest prevalent districts in Karnataka areDakshina Kannada for malaria, Udupi for dengue, Tumakurufor chikungunya andBidar for lymphatic filariasis. Major factors related to poor outcome in some districts were rigid attitude of the community, poor support of local panchayats and less human resources.Conclusion:The result of this investigation revealed that Dakshina Kannada has got highest number of cases with greater proposition and high prevalence rate of vector borne diseases due to lack of sufficient human resources and geographical factors. Strengthening the surveillance activities along with integrated vector control programmes will improves the outcome of the programme.
The practice and guidance and counseling in Amhara region Ethiopia.
Authors: Legas Alebachew Mohammed , Mengistu Antehun Atanaw 
Published: January 2019

The Practice of guidance and counseling service in Amhara region public universityâ€™s Ethiopia.
Alebachew Mohammed1 and Antehun Atanaw2
1Department of psychology, Debere Tabor university E-mail, alebemohaa@gmail.com
2Department of English language and literature, Debere Tabor university E-mail, antehuns@gmail.com
Abstract
Supporting students through their academic and social development are central mission of any university. This study aimed to assess the practice of guidance and counseling service in Amhara region public universities. The study was conducted on Bahir Dar university, Wollo university and Debre Tabor university. Through using sample size determination formula 576 regular students by stratified random sampling and 4 counselors using comprehensive sampling techniques were selected. The data was gathered through observation, interview and questionnaire. The collected data were analyzed qualitatively through narration of words and descriptive statistics of frequency and percentage. The finding indicates all counselors except Debre Tabor university donâ€™t have female counselors as well all are first degree. Furthermore, the average the ratio of one counselor is 5-10,000 students. Regarding the awareness, majority of student 69%-77.1% of student donâ€™t know the office location of the counselor. Approximately 1% of Bahir Dar university, 3% of Debere Tabor university, 4% of Wollo university students were reported using the service. Among this 28(50.9%) of student evaluated the service as not helpful. Regarding the referral of student by academic staffs (Instructors, departments and Facultyâ€™s) to counselor found poor. Furthermore, counselors are not formally delegated to attend issues that concern students like Forum, discipline and HIV etc. which might be helpful for the intervention. All university use Regular government working time and no night, weekend, telephone counseling service. Student consult their problems mainly to their friends, mothers and religious father. Teachers and counselors are among the least possible source of advisee. In conclusion, the general service provision of guidance and counseling were found poor and given less attention by universities. Thus, ministry of education and the university officials should give due attention by restructuring the office and allocation of resource and experts.
Key word; guidance and counseling, student, counselor, personal and social problems
Crímenes inmemoriales: nota roja y Material de los sueños
Authors: Flores Esquivel Enrique 
Published: January 2019

Desde el comienzo de su trayectoria, José Revueltas revela una atracción persistente por los casos criminales, sus repercusiones populares y su investigación filosófica. A partir de la exploración del submundo de la nota roja y los impresos populares, yde una inmersión a fondo en los archivos judiciales, sus últimos trabajos profundizan una reflexión a veces excesiva y delirante sobre el crimen y su memoria, la libertad y la ley, el “acto profundo” y el olvido de un crimen cometido antes, en el marco de una especulación que apela a los recursos narrativos —poética en el fondo, y a veces psicoanalítica—. Este trabajo aborda, sobre todo a partir de las notas y borradores dejados por Revueltas, dos fragmentos de ese último periodo: el relato “Hegel y yo”, de Material de los sueños, y las páginas de su novela inacabada: El tiempo y el número. Y con el trasfondo del sueño y la muerte.