bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality management of the apiproduct from the drone larvae
Authors: Prokhoda I A , Eliseeva E V , Katunina N P , Laktyushina O V , Tachkova I A , Litvin F B 
Published: June 2019

Abstract
The paper deals with the process of the apiproduct quality management, reflects the organization of its production and the factors that form and preserve the native properties of a highly biologically active product from the drone larvae. Possibility of the apiproduct manufacturing at the small innovative enterprise “Apiproduct” (SIE “Apiproduct” Ltd.) in two forms - as a paste and a powder - is demonstrated in the article. The main qualitative indicators - the organoleptic (color, taste, smell and consistency) and the physicochemical (mass fraction of water, proteins, fats, sugars, amino acids and fatty acids, vitamins and minerals) ones have been studied. According to the results of the organoleptic tests of the paste and powder, it has been identified that these are the pasty and powdery substances of the light yellow with a pleasant bread taste, without any foreign tastes and smells; they completely dissolve in water, their pH is 5.8 … 7.0, and they do not contain any mechanical impurities. According to the results of physical and chemical studies, it has been established that this is the paste with a solids content of 23.2%; it contains 13.2% of proteins, up to 9.5% of sugars and 1.2% of fats. It is established that the powder is characterized by a significant content of proteins (51.2%), vitamins and minerals, the content of which is 4 times higher than in the paste. The contained protein refers to a full-fledged one, and on the lysine, tryptophan and histidine it exceeds the level of ideal protein on the FAO/WHO scale by several times. The apiproduct contains up to 5% of fats and 28 higher fatty acids. The quantitative composition of fats practically corresponds to the formula of a balanced diet. The authors found that the factors shaping the quality of the apiproduct include raw materials and production technology. The author’s technology for the production of the apiproduct “Bilar” includes the following stages: cultivation, reception and grinding of larvae to biomass, sublimation vacuum drying of the biomass and obtaining a powder with a mass fraction of moisture of 2%. It has been established that drying preserves biologically active substances (β-carotene and α-tocopherol) and biopolymers (proteins, lipids and sugars) by 98.8 … 99.5%. The factors that preserve the quality of the apiproduct include packaging and storage.
Mechanism for managing the transition to sustainable development of natural-anthropogenic complexes of rural areas created as a result of the production of grain crops
Authors: Shumakova O V , Nardin D S , Nardina S A 
Published: June 2019

Abstract
The article substantiates a methodological approach to the formation of a mechanism for managing the transition to the sustainable development of natural and anthropogenic complexes in rural areas of the region, created as a result of grain production. A method of analyzing the level of impact of natural and anthropogenic complexes on natural landscapes and the level of socio-economic development of rural areas of the region has been developed. The methodology analyzed and proposed a set of measures aimed at creating a mechanism for managing the transition to sustainable development of natural and anthropogenic complexes in rural areas of the Omsk region.
Developing an emulsion product with a functional purpose using an emulsifier of plant origin
Authors: Zhmurina N D , Yu Kobzeva S , Shelepina N V , Baturina N A , Vlasova M V 
Published: June 2019

Abstract
Emulsion products, with vegetable oil in a dispersed state, occupy a definite place among promising fatty foods, which increases their digestibility and nutritional value. In addition, food emulsions for different populations can be created by changing the ratios of different types of oil in the recipe. The presence of the aqueous phase allows one to enter into the composition of the emulsions of water-soluble physiologically functional ingredients, as well as the use of non-traditional emulsifiers of plant origin. Therefore, work in this direction is promising. The article assesses consumer motivation when choosing sauces, as one of the stages of creating functional products, in order to study the demand for new functional sauces. Theoretically, based on the study of chemical and amino acid composition, as well as the organoleptic evaluation of the powder from dried champignons, the expediency of its use is justified as an emulsifier of vegetable origin in the production of emulsion products of functional purpose. Based on experimental studies to establish the technological parameters for the production of an emulsion product, the following parameters were determined: optimum soaking temperature, soaking time, optimal hydromodule of the mushroom powder, concentration of the wet mushroom powder, and optimal emulsion emulsification modes. Optimization of the fat component in the emulsion product was conducted in the ratio of ω-3 and ω-6=10: 1 fatty acids for a healthy diet. Scientifically based technology and formulation of an emulsion product of a functional purpose using as a emulsifier powder of dried champignons with a balanced fatty acid composition (for healthy nutrition) and structural and mechanical characteristics as close as possible to the mayonnaise sauce. Comparative characteristics produced chemical composition and organoleptic evaluation of the emulsion product using as an emulsifier of vegetable origin and mayonnaise sauce. The absence of cholesterol, reduced energy value can be attributed to the developed emulsion product to products for healthy people and for people with high cholesterol. The high content of potassium and sodium allows its use in the diet of people with cardiovascular diseases.
Dehydration and renal failure in older persons during heatwaves-predictable, hard to identify but preventable?
Authors: Brennan Michelle , O’Keeffe Shaun T , Mulkerrin Eamon C 
Published: June 2019

Abstract
Extremes of temperature are likely to increase in frequency associated with climate change. Older patients are particularly vulnerable to the effects of heat with excess mortality well documented in this population. Age-associated neurohormonal changes particularly affecting the renin angiotensin aldosterone system (RAAS), alterations in thermoregulatory mechanisms, changes in renal function and body composition render older persons vulnerable to dehydration, renal failure, heat stroke and increased mortality. Barriers to diagnosis and recognition of dehydration and renal failure include the absence of reliable clinical signs and cost-effective diagnostic tools. Regularly used medications also impact on physiological responses to excess heat as well as interfering with the recognition and management of dehydration during heat waves. In view of the above, anticipatory measures should be instituted ideally prior to the onset of heat waves to minimise morbidity and mortality for older people during periods of excess heat.
The extraction of complex relationships and their conversion to biological expression language (BEL) overview of the BioCreative VI (2017) BEL track
Authors: Madan Sumit , Szostak Justyna , Komandur Elayavilli Ravikumar , Tsai Richard Tzong-Han , Ali Mehdi , Qian Longhua , Rastegar-Mojarad Majid , Hoeng Julia , Fluck Juliane 
Published: June 2019

Abstract
Knowledge of the molecular interactions of biological and chemical entities and their involvement in biological processes or clinical phenotypes is important for data interpretation. Unfortunately, this knowledge is mostly embedded in the literature in such a way that it is unavailable for automated data analysis procedures. Biological expression language (BEL) is a syntax representation allowing for the structured representation of a broad range of biological relationships. It is used in various situations to extract such knowledge and transform it into BEL networks. To support the tedious and time-intensive extraction work of curators with automated methods, we developed the BEL track within the framework of BioCreative Challenges. Within the BEL track, we provide training data and an evaluation environment to encourage the text mining community to tackle the automatic extraction of complex BEL relationships. In 2017 BioCreative VI, the 2015 BEL track was repeated with new test data. Although only minor improvements in text snippet retrieval for given statements were achieved during this second BEL task iteration, a significant increase of BEL statement extraction performance from provided sentences could be seen. The best performing system reached a 32% F-score for the extraction of complete BEL statements and with the given named entities this increased to 49%. This time, besides rule-based systems, new methods involving hierarchical sequence labeling and neural networks were applied for BEL statement extraction.
Never drop your guard down after atrial septal defect closure: a case report
Authors: Bergonti Marco , Toscano Olga , Teruzzi Giovanni , Trabattoni Daniela 
Published: June 2019

Abstract

Background
Percutaneous atrial septal defect (ASD) closure carries a not negligible burden of complications, such as the erosion of cardiac structures surrounding the device. Complications related to erosion are rare and often occur during the first 6 months after implantation.

Case summary
A 40-year-old female patient underwent percutaneous ASD closure in 2006. After 12 years of uneventful follow-up, in March 2018, a device dislodgement causing atrial shunting was incidentally discovered and was attributed to device-induced atrial septal erosion. The patient successfully underwent surgical removal of the device and correction of the interatrial defect.

Discussion
Our purpose is to underline the importance of staged long-term imaging follow-up, even many years after a successful procedure and to highlight the possible risk factors leading to this worrisome condition. In addition, we sought to underline the possible risks associated with deficient aortic rim and explain pros and cons of different approaches.
AAV-based gene therapies for the muscular dystrophies
Authors: Crudele Julie M , Chamberlain Jeffrey S 
Published: June 2019

Abstract
Muscular dystrophy (MD) is a group of progressive genetic diseases affecting the musculature that are characterized by inflammatory infiltrates, necrosis and connective tissue and fat replacement of the affected muscles. Unfortunately, treatments do not exist for the vast majority of MD patients. Adeno-associated viral vector (AAV)-based gene therapy is thus emerging as a potential treatment for many types of MD. Treatments strategies based on AAV are being adapted for replacement of mutant disease-causing genes, knockdown of dominant disease-causing genes using antisense oligonucleotides or inhibitory RNAs, delivery of gene editing tools such as clustered regularly interspaced short palindromic repeats/Cas9 and effecting alterations in pre-mRNA splicing and by manipulating expression levels of modifier genes. Translational and clinical trial work focused on these types of AAV treatments for Duchenne MD, various limb girdle MDs, myotonic dystrophy 1, facioscapulohumeral MD, dysferlinopathies and congenital MDs are discussed here, with a focus on recent studies, pre-clinical large animal work and many promising ongoing and upcoming AAV clinical trials.
Gene therapy for glycogen storage diseases
Authors: Kishnani Priya S , Sun Baodong , Koeberl Dwight D 
Published: June 2019

AbstractThe focus of this review is the development of gene therapy for glycogen storage diseases (GSDs). GSD results from the deficiency of specific enzymes involved in the storage and retrieval of glucose in the body. Broadly, GSDs can be divided into types that affect liver or muscle or both tissues. For example, glucose-6-phosphatase (G6Pase) deficiency in GSD type Ia (GSD Ia) affects primarily the liver and kidney, while acid α-glucosidase (GAA) deficiency in GSD II causes primarily muscle disease. The lack of specific therapy for the GSDs has driven efforts to develop new therapies for these conditions. Gene therapy needs to replace deficient enzymes in target tissues, which has guided the planning of gene therapy experiments. Gene therapy with adeno-associated virus (AAV) vectors has demonstrated appropriate tropism for target tissues, including the liver, heart and skeletal muscle in animal models for GSD. AAV vectors transduced liver and kidney in GSD Ia and striated muscle in GSD II mice to replace the deficient enzyme in each disease. Gene therapy has been advanced to early phase clinical trials for the replacement of G6Pase in GSD Ia and GAA in GSD II (Pompe disease). Other GSDs have been treated in proof-of-concept studies, including GSD III, IV and V. The future of gene therapy appears promising for the GSDs, promising to provide more efficacious therapy for these disorders in the foreseeable future.
A power for the future? Global Britain and the future character of conflict
Authors: Uttley Matthew , Wilkinson Benedict , van Rij Armida 
Published: June 2019

Abstract
This article explores how the United Kingdom Ministry of Defence's (MoD) institutional vision of the potential future character of conflict is reflected in current defence policy decision-making and future force development planning. On the face of it, institutional arrangements in the MoD suggest that the results of ‘horizon-scanning’ and ‘futures’ analysis guide long-term defence planning in the design and development of the UK's future military roles and force structure. Our analysis points to the opposite. It suggests that it is the unchallenged assumption that the UK will remain a ‘Tier One’ defence power capable of deploying military power on a global scale and the MoD's long-term planning cycle that shape long-range forecasts of the future operating environment, rather than the other way round. Our explanation for this inversion is derived from the ‘New Institutionalism’ approach to public policy analysis. In taking this approach, we suggest that the outcomes of UK defence policy formation are strongly influenced by path dependency in the form of baked-in institutional ideas about the ‘appropriate’ role of Britain as a military power (‘what should be done’), along with historical capability investments underpinning UK defence that are costly to reverse (‘what can be changed’). By extension, we argue that if these embedded path dependencies explain the development of previous and current UK defence policy, then it should come as no surprise that the current ends, ways and means in UK defence are projected forward in the MoD's institutional view of potential future operating environments, resulting in limited change within established paths.
Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats
Authors: Pradhan Amynah A , Tipton Alycia F , Zhang Huaibo , Akbari Areeb , Pandey Subhash C 
Published: June 2019

Abstract

Background
Increased pain sensitivity is observed following alcohol withdrawal, and attempts to alleviate this hyperalgesia can contribute to the cycle of addiction. The aim of this study was to determine if alcohol withdrawal-induced hyperalgesia was observed in a chronic ethanol exposure model and if this pain was affected by histone deacetylase inhibitors, thus revealing an epigenetic mechanism.

Methods
Adult male Sprague Dawley rats received Lieber-DeCarli liquid control or ethanol (9% v/v) diet for 15 days. Mechanical sensitivity was measured with von Frey hair stimulation of the hindpaw during ethanol administration and 24- and 72-hour withdrawal.

Results
Ethanol withdrawal produced severe and sustained mechanical hyperalgesia, an effect not observed in the control or ethanol-maintained groups. Furthermore, this hyperalgesia was attenuated by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid treatment.

Conclusions
Heightened pain sensitivity was observed following withdrawal from chronic ethanol exposure, and histone deacetylase inhibitors could be novel treatments for this alcohol withdrawal-induced hyperalgesia.
Eye Movements in Frogs and Salamanders—Testing the Palatal Buccal Pump Hypothesis
Authors: Witzmann F , Brainerd E L , Konow N 
Published: June 2019

SynopsisIn frogs and salamanders, movements of the eyeballs in association with an open palate have often been proposed to play a functional role in lung breathing. In this “palatal buccal pump,” the eyeballs are elevated during the lowering of the buccal floor to suck air in through the nares, and the eyeballs are lowered during elevation of the buccal floor to help press air into the lungs. Here, we used X-Ray Reconstruction of Moving Morphology to investigate eye movements during lung breathing and feeding in bullfrogs and axolotls. Our data do not show eye movements that would be in accordance with the palatal buccal pump. On the contrary, there is a small passive elevation of the eyeballs when the buccal floor is raised. Inward drawing of the eyeballs occurs only during body motion and for prey transport in bullfrogs, but this was not observed in axolotls. Each eye movement in bullfrogs has a vertical, a mediolateral, and an anteroposterior component. Considering the surprisingly weak posterior motion component of the eyeballs, their main role in prey transport might be fixing the prey by pressing it against the buccal floor. The retraction of the buccal floor would then contribute to the posterior push of the prey. Because our study provides no evidence for a palatal buccal pump in frogs and salamanders, there is also no experimental support for the idea of a palatal buccal pump in extinct temnospondyl amphibians, in contrast to earlier suggestions.
In Brands We Trust? A Multicategory, Multicountry Investigation of Sensitivity of Consumers’ Trust in Brands to Marketing-Mix Activities
Authors: Rajavi Koushyar , Kushwaha Tarun , Steenkamp Jan-Benedict E M 
Published: June 2019

Abstract
The essence of a brand is that it delivers on its promises. However, consumers’ trust in brands (CTB) has declined around the world in recent decades. As a result, CTB has become a major concern for managers. The authors examine whether CTB is influenced by marketing-mix activities (i.e., advertising, new product introduction, distribution, price, and price promotion) implemented by brands. The authors propose and show that the sensitivity of CTB to marketing-mix activities is moderated by consumer, category, and country characteristics, using a multisource data set consisting of a survey of 15,073 respondents and scanner panel data on 589 brands in 46 CPG categories across 13 countries (including the four largest emerging markets), which collectively account for half of the world’s population. The authors find strong positive effects for advertising and new product introduction intensity, weak positive effects for price and distribution intensity, and a minor negative effect for price promotion intensity on CTB. Furthermore, the authors find that the effect of marketing-mix activities on CTB is moderated by consumers’ personality traits, consumers’ reliance on brands in a category, and countries’ secular-rational and self-expression cultural values.
Differential Impacts of Citrus Thrips Across Sweet Orange and Mandarin Species
Authors: Mueller Tobias G , Kahl Hanna M , Cass Bodil N , Grafton-Cardwell Elizabeth E , Rosenheim Jay A 
Published: June 2019

AbstractSeveral domesticated Citrus species are grown as major commercial crops in California. Despite this, farmers currently use a single set of management practices, originally created for sweet oranges (Citrus sinensis (L.) Osbeck [Sapindales: Rutaceae]), for both sweet oranges and all mandarin species. Mandarins, primarily Citrus reticulata Blanco, Citrus clementina hort. ex Tanaka, and Citrus unshiu Marcovitch, comprise almost 25% of California citrus acreage, and little work has been done to assess host–pest interactions for these species. Citrus thrips (Scirtothripscitri Moulton [Thysanoptera: Thripidae]) are one of the main pests in California citrus and are major targets for early spring, “petal fall” insecticide applications. We used mixed species citrus blocks to test the influence of Citrus species, including C. sinensis, C. reticulata, C. clementina, and C. unshiu, on 1) citrus thrips densities following petal fall; 2) citrus thrips-induced scarring on both the calyx and stylar ends of fruit; and 3) fruit deformation. Citrus sinensis and C. unshiu had relatively high citrus thrips densities and scarring levels, whereas C. reticulata had lower densities of citrus thrips and scarring levels. The age structure of citrus thrips populations also varied across Citrus species. Fruit deformity associated with citrus thrips scarring was found on all Citrus species examined. Scarring on the stylar-end of fruit, a previously largely ignored location of citrus thrips scarring, was found to be common in C. reticulata. It is clear from our work that species-specific management guidelines for citrus thrips are needed in sweet oranges and mandarins.
The repeated cytogenetic analysis of subjects occupationally exposed to nanoparticles: a pilot study
Authors: Rossnerova Andrea , Pelclova Daniela , Zdimal Vladimir , Rossner Pavel , Elzeinova Fatima , Vrbova Kristyna , Topinka Jan , Schwarz Jaroslav , Ondracek Jakub , Kostejn Martin , Komarc Martin , Vlckova Stepanka , Fenclova Zdenka , Dvorackova Stepanka 
Published: June 2019

Abstract
The application of nanomaterials has been rapidly increasing during recent years. Inhalation exposure to nanoparticles (NP) may result in negative toxic effects but there is a critical lack of human studies, especially those related to possible DNA alterations. We analyzed pre-shift and post-shift a group of nanocomposite researchers with a long-term working background (17.8 ± 10.0 years) and matched controls. The study group consisted of 73.2% males and 26.8% females. Aerosol exposure monitoring during a working shift (involving welding, smelting, machining) to assess the differences in exposure to particulate matter (PM) including nanosized fractions <25–100 nm, and their chemical analysis, was carried out. A micronucleus assay using Human Pan Centromeric probes, was applied to distinguish between the frequency of centromere positive (CEN+) and centromere negative (CEN−) micronuclei (MN) in the binucleated cells. This approach allowed recognition of the types of chromosomal damage: losses and breaks. The monitoring data revealed differences in the exposure to NP related to individual working processes, and in the chemical composition of nanofraction. The cytogenetic results of this pilot study demonstrated a lack of effect of long-term (years) exposure to NP (total frequency of MN, P = 0.743), although this exposure may be responsible for DNA damage pattern changes (12% increase of chromosomal breaks—clastogenic effect). Moreover, short-term (daily shift) exposure could be a reason for the increase of chromosomal breaks in a subgroup of researchers involved in welding and smelting processes (clastogenic effect, P = 0.037). The gender and/or gender ratio of the study participants was also an important factor for the interpretation of the results. As this type of human study is unique, further research is needed to understand the effects of long-term and short-term exposure to NP.