bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal control analysis of deterministic and stochastic epidemic model with media awareness programs
Authors: Gani Shrishail Ramappa , Halawar Shreedevi Veerabhadrappa 
Published: November 2018

The present study considered the optimal control analysis of both deterministic differential equation modeling and stochastic differential equation modeling of infectious disease by taking effects of media awareness programs and treatment of infectives on the epidemic into account. Optimal media awareness strategy under the quadratic cost functional using Pontrygin's Maximum Principle and Hamiltonian-Jacobi-Bellman equation are derived for both deterministic and stochastic optimal problem respectively. The Hamiltonian-Jacobi-Bellman equation is used to solve stochastic system, which is fully non-linear equation, however it ought to be pointed out that for stochastic optimality system it may be difficult to obtain the numerical results. For the analysis of the stochastic optimality system, the results of deterministic control problem are used to find an approximate numerical solution for the stochastic control problem. Outputs of the simulations shows that media awareness programs place important role in the minimization of infectious population with minimum cost.
Computational Analysis for Mixed Convective Flows of Viscous Fluids With Nanoparticles
Authors: Farooq Umer , Lu DianChen , Ahmed Salim , Ramzan Muhammad , Chung Jae Dong , Ali Chandio Farman 
Published: November 2018

Abstract
In this article, magnetohydrodynamic (MHD) mixed convection in an exponentially stretchable surface saturated with viscous fluid has been studied. BVPh 2.0 is employed which is mathematica-based algorithm created on the basis of optimal homotopy analysis method (OHAM). Adequate transformations are utilized for the conversion of governing system into nonlinear ordinary differential system. Convergence of BVPh 2.0 results is demonstrated through tabular values of squared residual errors. Graphical analysis is executed for broad range of governing parameters. It has been revealed an increase in buoyancy leads to the growth of boundary layer width. Further results predict the heat infiltration into the fluid increases as Brownian motion and Biot number enlarges. Mathematically this work exhibits the potential of BVPh 2.0 for nonlinear differential systems.
Anticoagulant therapies for acute venous thromboembolism: a comparison between those discharged directly from the emergency department versus hospital in two Canadian cities
Authors: Bungard Tammy J , Ritchie Bruce , Bolt Jennifer , Semchuk William M 
Published: November 2018

ObjectiveTo compare the characteristics/management of acute venous thromboembolism (VTE) for patients either discharged directly from the emergency department (ED) or hospitalised throughout a year within two urban cities in Canada.DesignRetrospective medical record review.SettingHospitals in Edmonton, Alberta (n=4) and Regina, Saskatchewan (n=2) from April 2014 to March 2015.ParticipantsAll patients discharged from the ED or hospital with acute deep vein thrombosis or pulmonary embolism (PE). Those having another indication for anticoagulant therapy, pregnant/breast feeding or anticipated lifespan <3 months were excluded.Primary and secondary outcomesPrimarily, to compare proportion of patients receiving traditional therapy (parenteral anticoagulant±warfarin) relative to a direct oral anticoagulant (DOAC) between the two cohorts. Secondarily, to assess differences with therapy selected based on clot burden and follow-up plans postdischarge.Results387 (25.2%) and 665 (72.5%) patients from the ED and hospital cohorts, respectively, were included. Compared with the ED cohort, those hospitalised were older (57.3 and 64.5 years; p<0.0001), more likely to have PE (35.7% vs 83.8%) with a simplified Pulmonary Embolism Severity Index (sPESI) ≥1 (31.2% vs 65.2%), cancer (14.7% and 22.3%; p=0.003) and pulmonary disease (10.1% and 20.6%; p<0.0001). For the ED and hospital cohorts, similar proportions of patients were prescribed traditional therapies (72.6% and 71.1%) and a DOAC (25.8% and 27.4%, respectively). For the ED cohort, DOAC use was similar between those with a sPESI score of 0 and ≥1 (35.1% and 34.9%, p=0.98) whereas for those hospitalised lower risk patients were more likely to receive a DOAC (31.4% and 23.8%, p<0.055). Follow-up was most common with family physicians for those hospitalised (51.5%), while specialists/VTE clinic was most common for those directly discharged from the ED (50.6%).ConclusionsTraditional and DOAC therapies were proportionately similar between the ED and hospitalised cohorts, despite clear differences in patient populations and follow-up patterns in the community.
Effect of physical exercise on weight loss and physical function following bariatric surgery: a meta-analysis of randomised controlled trials
Authors: Ren Zi-Qi , Lu Guang-Dong , Zhang Tian-Zi , Xu Qin 
Published: November 2018

ObjectivesWe performed a meta-analysis of all of the available randomised controlled trials (RCTs) to investigate whether physical exercise contributes to weight loss or physical function improvement in adults receiving bariatric surgery.MethodsWe searched PubMed, Embase, the Cochrane Library, OVID and the CINAHL up through May 2018. RCTs that assigned adults with obesity to either an exercise training group or a no-exercise group after bariatric surgery were included. The primary outcomes were weight loss and physical function. Study bias was assessed using the Cochrane risk of bias tool, and the quality of evidence was assessed using GRADEpro.ResultsA total of eight studies met the inclusion criteria (n=347 participants). Most of the studies carried a low risk of bias due to randomisation and blinding. Compared with those without exercise intervention after surgery, patients engaging in physical exercise were associated with greater weight loss (weighted mean difference (WMD) −1.94 kg; 95% CI −3.18 to −0.69; n=8) and longer 6 min walk distance (6MWD; WMD29.67 m; 95% CI 25.97 to 33.37; n=2) during follow-up. By subgroup analyses, the additional weight loss in exercise group was related to the starting time and type of exercise: patients engaging in exercise 1 year or more after surgery and patients received aerobic–resistance exercise experienced more weight loss. Besides, patients in exercise training group also had lower systolic blood pressure and resting heart rate after surgery. The quality of evidence for these outcomes was moderate to very low.ConclusionsPhysical exercise after bariatric surgery provides 1.94 kg additional weight loss and 29.67 m longer 6MWD compared with surgery alone. Moreover, engaging in exercise 1 year or more after surgery, and a combined aerobic and resistance training programme may result in greater weight loss.
Expanded teased nerve fibre pathological conditions in disease association
Authors: Xu Min , Pinto Marcus , Sun Chenjing , Engelstad Janean K , James Dyck P , Dyck Peter J , Klein Christopher J 
Published: November 2018

ObjectiveTo describe an expanded teased nerve fibre classification in disease association.MethodsWe reviewed four newly proposed teased nerve fibre types (Types J–M): Type J, rope-like fibres; K, fibril-like clumps of osmium positivity; L, cellular debris along and within nerve fibres; M, circular axonal inclusions surrounded by thin myelin. Different clinical pathological entities were studied for these fibre types including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP: N=20); amyloid polyneuropathy (N=20); intraneural B-cell lymphoma (N=20) or adult-onset polyglucosan body disease (APBD: N=6) in comparison with 112 disease controls. Student’s t-test was used to test significance of association between the identified fibre types and the specific clinical diagnosis.ResultsEach fibre type significantly associated (p<0.001) with particular disease categories: Type J, 60% of CIDP cases; Type K, 75% of amyloid cases; Type L, 75% of intraneural lymphoma cases; Type M, 100% of APBD cases. Rarely were these fibres found in the other disease control cases ≤3% of cases. In three cases, the teased fibre findings were so striking additional paraffin nerve preparations were made to make the pathological diagnosis when initial paraffin sections were non-diagnostic.ConclusionsTeased nerve fibre Types J–M associate with commonly seen pathological diagnosis and are helpful in the consideration of specific neuropathy diagnoses.
German military geology and military mining on the Eastern Front in World War I
Authors: Willig Dierk 
Published: November 2018

Abstract

At its peak, the Eastern Front encompassed the entire frontier between the Russian Empire and Romania on the Allied side and the Austro-Hungarian Empire, Bulgaria, the (Turkish) Ottoman Empire and the German Empire on the other: a distance of
c.
1500–1700 km. Mobile warfare alternated with periods of static trench and siege warfare, when ‘mines’ (tunnels charged with explosives detonated to breach the overhead fortifications) and ‘dugouts’ (to protect troops from artillery or aerial bombardment) were constructed in at least 50 localities between 1915 and 1917, from Mitau in present-day Latvia to Rarancze in Moldova. Terrain ranged from plateaux floored by Cenozoic sediments in the north to mountains with more complex, older, stronger rocks in the south. Despite lessons learnt from the Russo-Japanese war of 1904–05, both sides began the conflict unprepared for tunnelling warfare. However, German and Austro-Hungarian forces soon developed units of military geologists whose duties included guidance of tunnelling projects. Eight teams of German military geologists and four of Austro-Hungarian, in total over 60 men who can be named, are known to have served on the Front, as did newly formed and equipped specialist engineer mining battalions from Prussia, Bavaria and Austria-Hungary.
The influence of layer-interface geometry on single-layer folding
Authors: Griera Albert , Gomez-Rivas Enrique , Llorens Maria-Gema 
Published: November 2018

Abstract

Geometrical heterogeneities along layer interfaces play a key role in determining the geometries of folds developed during shortening of competent layers. We present a series of numerical simulations to investigate the influence of initial sinusoidal perturbations on the folding of single layers. Models consist of a competent viscous single layer embedded in a softer matrix, with the layer orientated parallel to the shortening direction. We first generalize the wide spectrum of sinusoidal perturbations accounting for asymmetries along and across a competent single layer, using two parameters: transversal asymmetry (
A
′) and longitudinal asymmetry (
φ
). These two parameters allow the transition between classical fold shapes and pinch and swell geometries to be studied. The parameter
A
′ describes the development of fold hinges with different geometries between the upper and lower layer interfaces, and abnormal curvatures between the outer and inner arcs of fold hinges. The parameter
φ
induces a strong polarity on the folds, with a systematic preferred orientation of the pinch and swell regions of the layer, even if there is no shear component parallel to the layer. Our results demonstrate the importance of structural inheritance on the resulting fold geometries, and suggest that caution must be taken when using certain types of asymmetrical folds as strain markers and kinematic indicators.
Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans
Authors: Fujii Naoto , Kashihara Miki , Kenny Glen P. , Honda Yasushi , Fujimoto Tomomi , Cao Yinhang , Nishiyasu Takeshi 
Published: November 2018

Hyperthermia causes hyperventilation at rest and during exercise. We previously reported that carotid chemoreceptors partly contribute to the hyperthermia-induced hyperventilation at rest. However, given that a hyperthermia-induced hyperventilation markedly differs between rest and exercise, the results obtained at rest may not be representative of the response in exercise. Therefore, we evaluated whether carotid chemoreceptors contribute to hyperthermia-induced hyperventilation in exercising humans. Eleven healthy young men (23 ± 2 yr) cycled in the heat (37°C) at a fixed submaximal workload equal to ~55% of the individual’s predetermined peak oxygen uptake (moderate intensity). To suppress carotid chemoreceptor activity, 30-s hyperoxia breathing (100% O2) was performed at rest (before exercise) and during exercise at increasing levels of hyperthermia as defined by an increase in esophageal temperature of 0.5°C (low), 1.0°C (moderate), 1.5°C (high), and 2.0°C (severe) above resting levels. Ventilation during exercise gradually increased as esophageal temperature increased (all P ≤ 0.05), indicating that hyperthermia-induced hyperventilation occurred. Hyperoxia breathing suppressed ventilation in a greater manner during exercise (−9 to −13 l/min) than at rest (−2 ± 1 l/min); however, the magnitude of reduction during exercise did not differ at low (0.5°C) to severe (2.0°C) increases in esophageal temperature (all P > 0.05). Similarly, hyperoxia-induced changes in ventilation during exercise as assessed by percent change from prehyperoxic levels were not different at all levels of hyperthermia (~15–20%, all P > 0.05). We show that in young men carotid chemoreceptor contribution to hyperthermia-induced hyperventilation is relatively small at low-to-severe increases in body core temperature induced by moderate-intensity exercise in the heat. NEW & NOTEWORTHY Exercise-induced increases in hyperthermia cause a progressive increase in ventilation in humans. However, the mechanisms underpinning this response remain unresolved. We showed that in young men hyperventilation associated with exercise-induced hyperthermia is not predominantly mediated by carotid chemoreceptors. This study provides important new insights into the mechanism(s) underpinning the regulation of hyperthermia-induced hyperventilation in humans and suggests that factor(s) other than carotid chemoreceptors play a more important role in mediating this response.
Cardiovascular responses during isometric exercise following lengthening and shortening contractions
Authors: Seed Jeremy D. , St. Peters Benjamin , Power Geoffrey A. , Millar Philip J. 
Published: November 2018

The present study investigated the effects of prior lengthening or shortening contractions on cardiovascular responses during isometric exercise. We utilized the history dependence of skeletal muscle, where active 2-s lengthening or shortening before an isometric contraction can increase [residual force enhancement (RFE)] or decrease [force depression (FD)] force production. Matching torque output between RFE and FD conditions yields lower and higher electromyography (EMG) values, respectively. In study 1, heart rate and perceived exertion (PE; Borg10) were measured in 20 participants during 20-s isometric plantar flexion contractions at low (16 ± 4% MVC)-, moderate (50 ± 5% MVC)-, and high (88 ± 7% MVC)-intensity. In study 2, heart rate and blood pressure were measured in 14 participants during 2-min isometric plantar flexion contractions (40% MVC). In both studies, torque output was held constant between FD and RFE conditions resulting in differences in soleus EMG activity ( P < 0.05). In study 1, PE was lower during the RFE condition ( P < 0.01), while increases in heart rate were similar between FD and RFE at low (∆2 ± 8 vs. 3 ± 6 beats/min, P > 0.99) and moderate (∆14 ± 9 vs. 14 ± 9 beats/min, P > 0.99) intensity but smaller during RFE at high intensity (∆35 ± 13 vs. 29 ± 13 beats/min, P = 0.004). In study 2, heart rate responses were smaller in the RFE condition following the initial 20-s period; diastolic blood pressure responses were smaller during the last 80 s. A 2-s active change in muscle length before an isometric contraction can influence heart rate and blood pressure responses; however, these differences appear to be modulated by both intensity and duration of the contraction. NEW & NOTEWORTHY Using the history dependence of isometric force to alter maximal torque production and motor unit activation between residual force enhancement and force depression conditions, we observed that heart rate responses were different between conditions during a subsequent 20-s high-, but not low- or moderate-, intensity isometric contraction. A 2-min moderate-intensity contraction revealed time-dependent effects on heart rate and diastolic blood pressure. Active 2-s shortening and lengthening before an isometric contraction can influence the cardiovascular responses.
Cardiorespiratory coupling in preterm infants
Authors: Joshi Rohan , Kommers Deedee , Long Xi , Feijs Loe , Van Huffel Sabine , van Pul Carola , Andriessen Peter 
Published: November 2018

In preterm infants, a better understanding and quantification of cardiorespiratory coupling may help improve caregiving by enabling the tracking of maturational changes and subclinical signatures of disease. Therefore, in a study of 20 preterm infants admitted to a neonatal intensive care unit, we analyzed the cardiac and respiratory regulatory mechanisms as well as the coupling between them. In particular, we selectively analyzed coupling from changes in heart rate to respiratory oscillations as well as coupling from respiratory oscillations to the heart rate. Furthermore, we stratified this coupling based on decelerations and accelerations of the heart rate and by inspiration and expiration during respiration while contrasting periods of kangaroo care, an intervention known to enhance autonomic regulation, with periods in the incubator. We identified that preterm infants exhibit cardiorespiratory coupling that is nonsymmetric with regard to the direction of coupling. We demonstrate coupling from decelerations and accelerations of the heart rate to exhalation and inhalation, respectively, both on a beat-to-beat basis as well as with sustained decelerations and accelerations. On the other hand, on average, we also observed coupling from both inspiration and expiration to marginal decelerations in the heart rate. These phenomena, especially coupling from the changes in the heart rate to respiratory oscillations, were sensitive to whether the infant was receiving kangaroo care. NEW & NOTEWORTHY Preterm infants exhibit cardiorespiratory coupling that is nonsymmetric with regard to the direction of coupling; coupling from fluctuations in the heart rate to respiratory oscillations and vice versa are asymmetric. On average, coupling is observable from decelerations or accelerations in the heart rate to inhalation or exhalation, respectively, whereas, on average, both peaks and troughs of respiration exhibit coupling to marginal decelerations in the heart rate.
NK cell function is impaired during long-duration spaceflight
Authors: Bigley Austin B. , Agha Nadia H. , Baker Forrest L. , Spielmann Guillaume , Kunz Hawley E. , Mylabathula Preteesh L. , Rooney Bridgette V. , Laughlin Mitzi S. , Mehta Satish K. , Pierson Duane L. , Crucian Brian E. , Simpson Richard J. 
Published: November 2018

Maintaining astronaut health during space travel is paramount for further human exploration of the solar system beyond Earth’s orbit. Of concern are potential dysregulations in immunity, which could increase the likelihood of cancer and latent viral reactivation. Natural killer (NK) cells are critical effectors of the innate immune system, and their function and phenotype are important to immunosurveillance of nascent tumors and latent viral infections. We compared changes in NK cell phenotype and function in eight crew members who completed an ~6-mo mission to the International Space Station (ISS) with healthy controls who remained on Earth. Assessments were made before (180 and 60 days before launch), during [flight day + 90 days (FD+90) and 1 day before return (R−1)], and after the mission (at R+0, R+18, R+33, and R+66). These samples, plus an additional in-flight sample (FD+180), were collected from a crew member who spent 340 days (~1 yr) on the ISS. NK cell cytotoxic activity (NKCA) against K562 leukemia targets in vitro was reduced by ~50% at FD+90 in ISS crew but not controls. This decrease was more pronounced in “rookie” compared with “veteran” crew members. The ~1-yr mission crew member did not show declines in NKCA against K562 until late in the mission (R−1 and R+0). NK cell numbers, expression of activating and inhibitory receptors, target cell binding, and expression and degranulation of perforin and granzyme B were unaltered with spaceflight. Similarly, when we exposed an immortalized NK cell line (NK-92) to sera collected at different mission time points (before, during, and after flight), there was no effect on NKCA. This is the first study to report impaired NK cell function during long-duration space travel. Countermeasures may be needed to mitigate immune system impairment in exploration class mission crew during long-duration spaceflight missions.NEW & NOTEWORTHY Immune system impairment may inhibit future human space exploration missions to Mars. Natural killer (NK) cells are key components of immunity and vital for tumor surveillance and the prevention of latent virus reactivation. We report that NK cell function is impaired in astronauts during an ~6-mo orbital space mission compared with preflight levels and ground-based controls. Declines in NK cell function were more marked in first-time “rookie” fliers. Countermeasures are needed to preserve NK cell-mediated immunity during spaceflight.
Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs
Authors: Allison Beth J. , LaRosa Domenic A. , Barton Samantha K. , Hooper Stuart , Zahra Valerie , Tolcos Mary , Chan Kyra Y. Y. , Barbuto Jade , Inocencio Ishmael M. , Moss Timothy J. , Polglase Graeme R. 
Published: November 2018

Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and systemic inflammation in preterm lambs. Ventilation was initiated in anaesthetized preterm lambs [125 ± 1 (SD) days gestation] using an injurious strategy for the first 15 min. Lambs were subsequently ventilated with a protective strategy for a total of 2 h. Lambs were randomized to receive either intravenous saline (Vent; n = 7) or intravenous 300 ( n = 5), 1,000 (EPO1000; n = 5), or 3,000 (EPO3000; n = 5) IU/kg of human recombinant EPO via an umbilical vein. Lung tissue was collected for molecular and histological assessment of inflammation and injury and compared with unventilated control lambs (UVC; n = 8). All ventilated groups had similar blood gas and ventilation parameters, but EPO1000 lambs had a lower fraction of inspired oxygen requirement and lower alveolar–arterial difference in oxygen. Vent and EPO lambs had increased lung interleukin (IL)-1β, IL-6, and IL-8 mRNA, early lung injury genes connective tissue growth factor, early growth response protein 1, and cysteine-rich 61, and liver serum amyloid A3 mRNA compared with UVCs; no difference was observed between Vent and EPO groups. Histological lung injury was increased in Vent and EPO groups compared with UVCs, but EPO3000 lambs had increased lung injury scores compared with VENT only. Early low-doses of EPO do not exacerbate ventilation-induced lung inflammation and injury and do not provide any short-term respiratory benefit. High doses (≥3,000 IU/kg) likely exacerbate lung inflammation and injury in ventilated preterm lambs. NEW & NOTEWORTHY Trials are ongoing to assess the efficacy of erythropoietin (EPO) to provide neuroprotection for preterm infants. However, high doses of EPO increase ventilation-induced lung injury (VILI) in preterm lambs. We investigated whether early lower doses of EPO may reduce VILI. We found that lower doses did not reduce, but did not increase, VILI, while high doses (≥3,000 IU/kg) increase VILI. Therefore, lower doses of EPO should be used in preterm infants, particularly those receiving respiratory support.