bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study
Authors: Novak G V , Molinari B C , Ferreira J C , Sakamoto A P , Terreri MT , Pereira R M R , Saad-Magalhães C , Aikawa N E , Campos L M , Len C A , Appenzeller S , Ferriani V P , Silva M F , Oliveira S K , Islabão A G , Sztajnbok F R , Paim L B , Barbosa C M , Santos M C , Bica B E , Sena E G , Moraes A J , Rolim A M , Spelling P F , Scheibel I M , Cavalcanti A S , Matos E N , Robazzi T C , Guimarães L J , Santos F P , Silva C T , Bonfá E , Silva C A 
Published: July 2018

Objective The objective of this study was to compare demographic data, clinical/laboratorial features and disease activity at diagnosis in three different groups with distinct time intervals between onset of signs/symptoms and disease diagnosis. Methods A multicenter study was performed in 1555 childhood-onset systemic lupus erythematosus (American College of Rheumatology criteria) patients from 27 pediatric rheumatology services. Patients were divided into three childhood-onset systemic lupus erythematosus groups: A: short time interval to diagnosis (<1 month); B: intermediate time interval (≥1 and <3 months); and C: long time interval (≥3 months). An investigator meeting was held to define the protocol. Demographic data, SLICC classification criteria and SLEDAI-2 K were evaluated. Results The number of patients in each group was: A = 60 (4%); B = 522 (33.5%); and C = 973 (62.5%). The median age at diagnosis (11.1 (4.2–17) vs. 12 (1.9–17.7) vs. 12.5 (3–18) years, P = 0.025) was significantly lower in group A compared with groups B and C. The median number of diagnostic criteria according to SLICC (7 (4–12) vs. 6 (4–13) vs. 6 (4–12), P < 0.0001) and SLEDAI-2 K (18 (6–57) vs. 16 (2–63) vs. 13 (1–49), P < 0.0001) were significantly higher in group A than the other two groups. The frequency of oral ulcers in the palate (25% vs. 15% vs. 11%, P = 0.003), pleuritis (25% vs. 24% vs. 14%, P < 0.0001), nephritis (52% vs. 47% vs. 40%, P = 0.009), neuropsychiatric manifestations (22% vs. 13% vs. 10%, P = 0.008), thrombocytopenia (32% vs. 18% vs. 19%, P = 0.037), leucopenia/lymphopenia (65% vs. 46% vs. 40%, P < 0.0001) and anti-dsDNA antibodies (79% vs. 66% vs. 61%, P = 0.01) were significantly higher in group A compared with the other groups. In contrast, group C had a less severe disease characterized by higher frequencies of synovitis (61% vs. 66% vs. 71%, P = 0.032) and lower frequencies of serositis (37% vs. 33% vs. 25%, P = 0.002), proteinuria >500 mg/day (48% vs. 45% vs. 36%, P = 0.002) and low complement levels (81% vs. 81% vs. 71%, P < 0.0001) compared with groups A or B. Conclusions Our large Brazilian multicenter study demonstrated that for most childhood-onset systemic lupus erythematosus patients, diagnosis is delayed probably due to mild disease onset. Conversely, the minority has a very short time interval to diagnosis and a presentation with a more severe and active multisystemic condition.
Composite urinary biomarkers to predict pathological tubulointerstitial lesions in lupus nephritis
Authors: Ding Y , Nie L-M , Pang Y , Wu W-J , Tan Y , Yu F , Zhao M-H 
Published: July 2018

Objective This study aimed to evaluate the clinical value of urinary biomarkers including kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis. Methods A total of 109 biopsy-proven lupus nephritis patients were included and 50 healthy individuals were used as normal controls. Urinary KIM-1, NGAL, and MCP-1 levels were measured by ELISA and their correlations with clinical and histological features were assessed. Receiver operating characteristic curves were performed and the Cox regression model was applied to identify prognostic factors associated with renal outcomes. Results Active lupus nephritis patients exhibited elevated urinary levels of KIM-1, NGAL, and MCP-1 compared with lupus nephritis patients in remission ( P < 0.001) and normal controls ( P < 0.001). The urinary KIM-1 level was correlated with pathological tubular atrophy ( r = 0.208, P < 0.05) and increased significantly in the presence of interstitial inflammatory lesions ( P = 0.031). Urinary KIM-1, NGAL, and MCP-1 levels were higher in patients with active tubulointerstitial lesions than in those with only chronic lesions ( P = 0.015, P = 0.230, and P = 0.086, respectively). A combination of KIM-1, NGAL, and MCP-1 was a good indicator for diagnosing active tubulointerstitial lesions (area under the curve: 0.796). The combination of KIM-1 and NGAL was identified as an independent risk factor for renal outcomes (hazard ratio = 7.491, P < 0.05). Conclusion Urinary KIM-1, NGAL, and MCP-1 levels were associated with kidney injury indices in lupus nephritis. The combination of the three biomarkers showed increased power in predicting tubulointerstitial lesions and renal outcomes.
Wear Characteristics of Conventional Ultrahigh-Molecular-Weight Polyethylene Versus Highly Cross-Linked Polyethylene in Total Ankle Arthroplasty
Authors: Schipper Oliver N. , Haddad Steven L. , Fullam Spencer , Pourzal Robin , Wimmer Markus A. 
Published: July 2018

Background: The aim of this study was to compare the polyethylene wear rate, particle size, and particle shape of primary semiconstrained, fixed-bearing, bone-sparing total ankle arthroplasty using conventional ultrahigh-molecular-weight polyethylene (CPE) versus highly cross-linked polyethylene (HXLPE) by applying a level walking input using a joint simulator. Methods: Two fixed-bearing total ankle replacement systems with different types of polyethylene liners were tested: (1) CPE sterilized in ethylene oxide, and (2) HXLPE sterilized with gas plasma after electron beam irradiation. Three implants for each design underwent wear testing using gravimetric analysis over 5 million simulated walking cycles. A fourth implant was used as a load soak control. Equivalent circle diameter (ECD) and equivalent shape ratio (ESR) were computed to determine particle size and particle shape, respectively. Results: The mean wear rate from 1.5 to 5 million cycles (MC) was 2.0 ± 0.3 mg/MC for HXLPE and 16.7 ± 1.3 mg/MC for CPE ( P < .001). The total number of particles per cycle generated for HXLPE and CPE were 0.17 × 106 particles/cycle and 0.53 × 106 particles/cycle, respectively ( P < .001). The mean ECD of HXLPE particles (0.22 ± 0.11 μm) was significantly smaller than the mean ECD of CPE particles (0.32 ± 0.14 μm) ( P < .001). HXLPE particles were significantly more round than CPE particles ( P < .001). Conclusions: HXLPE liners had a significantly lower wear rate and produced significantly fewer and rounder particles than CPE liners. The results of this study suggest that HXLPE has more favorable wear characteristics for total ankle arthroplasty. Clinical Relevance: Polyethylene wear particles have been linked to osteolysis after total ankle arthroplasty. There is no consensus on the importance of highly cross-linked polyethylene in total ankle arthroplasty with regard to implant wear. This is the first nonindustry study to compare the polyethylene wear rate, particle size, and particle shape of fixed-bearing total ankle arthroplasty conventional polyethylene versus highly cross-linked polyethylene. The lower wear rate and different particle size/morphology of highly cross-linked polyethylene could be beneficial in vivo to decrease osteolysis.
A penalized approach for the bivariate ordered logistic model with applications to social and medical data
Authors: Enea Marco , Lovison Gianfranco 
Published: July 2018

Bivariate ordered logistic models (BOLMs) are appealing to jointly model the marginal distribution of two ordered responses and their association, given a set of covariates. When the number of categories of the responses increases, the number of global odds ratios to be estimated also increases, and estimation gets problematic. In this work we propose a non-parametric approach for the maximum likelihood (ML) estimation of a BOLM, wherein penalties to the differences between adjacent row and column effects are applied. Our proposal is then compared to the Goodman and Dale models. Some simulation results as well as analyses of two real data sets are presented and discussed.
Validation of Breast Cancer Models for Predicting the Nonsentinel Lymph Node Metastasis After a Positive Sentinel Lymph Node Biopsy in a Chinese Population
Authors: Wu Peiqi , Zhao Ke , Liang Yanli , Ye Weitao , Liu Zaiyi , Liang Changhong 
Published: July 2018

Objectives: Over the years, completion axillary lymph node dissection is recommended for the patients with breast cancer if sentinel lymph node metastasis is found. However, not all of these patients had nonsentinel lymph node metastasis on final histology. Some predicting models have been developed for calculating the risk of nonsentinel lymph node metastasis. The aim of our study was to validate some of the predicting models in a Chinese population. Method: Two hundred thirty-six patients with positive sentinel lymph node and complete axillary lymph node dissection were included. Patients were applied to 6 models for evaluation of the risk of nonsentinel lymph node involvement. The receiver–operating characteristic curves were shown in our study. The calculation of area under the curves and false negative rate was done for each model to assess the discriminative power of the models. Results: There are 105 (44.5%) patients who had metastatic nonsentinel lymph node(s) in our population. Primary tumor size, the number of metastatic sentinel lymph node, and the proportion of metastatic sentinel lymph nodes/total sentinel lymph nodes were identified as the independent predictors of nonsentinel lymph node metastasis. The Seoul National University Hospital and Louisville scoring system outperformed the others, with area under the curves of 0.706 and 0.702, respectively. The area under the curve values were 0.677, 0.673, 0.432, and 0.674 for the Memorial Sloan-Kettering Cancer Center, Tenon, Stanford, and Shanghai Cancer Hospital models, respectively. With adjusted cutoff points, the Louisville scoring system outperformed the others by classifying 26.51% of patients with breast cancer to the low-risk group. Conclusion: The Louisville and Seoul National University Hospital scoring system were found to be more predictive among the 6 models when applied to the Chinese patients with breast cancer in our database. Models developed at other institutions should be used cautiously for decision-making regarding complete axillary lymph node dissection after a positive biopsy in sentinel lymph node.
Outcomes of cementless joint prosthesis versus tendon interposition for trapeziometacarpal osteoarthritis: a prospective study
Authors: Cebrian-Gomez Roman , Lizaur-Utrilla Alejandro , Sebastia-Forcada Emilio , Lopez-Prats Fernando A. 
Published: July 2018

We compared 84 patients with the Ivory trapeziometacarpal prosthesis versus 62 with ligament reconstruction and tendon interposition arthroplasty performed for osteoarthritis. There were 134 women and 12 men with a mean age of 60 years. Prospective clinical assessment was made using the Quick Disability of the Arm, Shoulder and Hand (DASH) questionnaire, visual analogue scale for pain, range of motion, and grip and pinch strength. The mean follow-up was 4 years (range 2–5). Prosthetic replacement provided significantly better thumb abduction, adduction, pinch strength, QuickDASH, pain relief, satisfaction and a faster return to daily activities and previous work. Revision surgery was required for two patients in the prosthesis group, two for dislocation and one cup loosening, while in the ligament reconstruction group there were no revisions. We conclude that trapeziometacarpal prosthesis provides better mid-term results in terms of function compared with ligament reconstruction and tendon interposition for patients with Stages 2 and 3 osteoarthritis of the trapeziometacarpal joint. Level of evidence: II
Health State Utilities in Edentulous Patients: A Time Trade-off Approach
Authors: Sendi P. , Oppliger N. , Chakroun F. , Marinello C.P. , Bucher H.C. , Bornstein M.M. 
Published: July 2018

Background: Health is generally regarded as a very high good, and oral health may substantially affect the quality of life of patients. Oral health–related quality of life has usually been investigated by means of disease-specific descriptive instruments, such as the Oral Health Impact Profile and the General Oral Health Assessment Index. These instruments, however, do not enable a comparison of oral health–related quality of life with other medical diseases. Economic methods, such as the time trade-off technique, enable a comparison of the impact of oral health with other medical diseases and thus provide a means to build a bridge in quality-of-life assessments between medicine and dentistry. Methods: We included in our study a total of 58 patients who received a complete denture in our clinic in the last 10 y (between January 2001 and May 2012) and who were ≥65 y old. Patient preferences for the edentulous and poorest imaginable oral health state were assessed via the time trade-off method. Results: Edentulous patients rated their current oral health state as 0.73 (SD, 0.25) and the poorest oral health state as 0.43 (SD, 0.33) on a scale between 0 (death) and 1 (best possible health state). These results are comparable to patient preferences for other serious diseases, such as breast cancer (0.75), asymptomatic HIV infection (0.69), depression (0.44), and osteoarthritis of the hip (0.44). Conclusion: In conclusion, our results suggest that oral health may substantially affect quality of life no less than other medical diseases. Knowledge Transfer Statement: Health is generally considered the highest good of humankind. In the present article, we show that oral health substantially affects quality of life. In particular, we show that loss of teeth (i.e., being edentulous) reduces quality of life no less than other systemic diseases. Treatment modalities for the edentulous patient may therefore substantially improve the patient’s well-being and should be a research priority.
Efficacy of 18F‐fluorodeoxyglucose PET/CT for Detecting Lymph Node Metastasis in Papillary Thyroid Carcinoma
Authors: Lee Dong Won , Song Chang Myeon , Ji Yong Bae , Kim Ji Young , Choi Yun Young , Lee Ji Young , Tae Kyung 
Published: July 2018

ObjectiveTo evaluate the efficacy of preoperative 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for detecting cervical lymph node (LN) metastasis in papillary thyroid carcinoma (PTC).Study DesignCase series with chart review.SettingUniversity tertiary care facility.Subjects and MethodsWe retrospectively compared the pathologic results for 409 cervical LN levels in 140 patients who underwent thyroidectomy and central neck dissection with/without lateral neck dissection with the findings of preoperative PET/CT, ultrasonography (US), and CT. We judged LN metastasis in PET/CT using the maximum standardized uptake value (SUVmax) at the optimal cutoff value in receiver operating characteristic curves and compared the sensitivity, specificity, and diagnostic accuracy of the 3 imaging tools.ResultsAt all neck levels (central and lateral compartments), PET/CT had a sensitivity of 57.5%, specificity of 68.6%, and diagnostic accuracy of 63.6% when the cutoff value of SUVmax was 1.125. The corresponding values were 59.1%, 90.6%, and 76.3%, respectively, for US and 53.8%, 91.9%, and 74.6% for CT. In the central compartment (level VI), sensitivity, specificity, and diagnostic accuracy were 48.9%, 67.4%, and 59.9% for PET/CT (cutoff SUVmax 1.125); 47.8%, 96.3%, and 76.7% for US; and 41.3%, 97.0%, and 74.4% for CT, respectively. In the lateral compartment (levels II‐V), the corresponding values of sensitivity, specificity, and diagnostic accuracy were 70.2%, 69.3%, and 69.8% for PET/CT (cutoff SUVmax 1.055); 70.2%, 81.8%, and 75.8% for US; and 65.9%, 84.1%, and 74.7% for CT.ConclusionPET/CT is less effective as a preoperative diagnostic tool for detecting cervical lymph node metastasis in PTC than US or CT.
Brette Pearl Spar Mable (BPSM): a potential recoverable catalyst as a renewable source of biodiesel from Thevetia peruviana seed oil for the benefit of sustainable development in West Africa
Authors: Adepoju T. F. , Olatunbosun B. E. , Olatunji O. M. , Ibeh M. A. 
Published: July 2018

Abstract
Background
The energy requirements are globally on a rapid escalation, as technology advances, which is also true for a developing country like Nigeria, which is dependent on fossil fuels and its derivatives. Apart from its adverse effect on its economy, it has also negative impacts on the health and the environment, in general. However, investments in renewable energy are faced by the competitive oil prices, the very high investment cost for renewable energy, and high local electricity prices. This paper appraises the attractiveness of investing in renewable energy sources over the continued use of non-edible oil for electricity generation.

Methods
This paper explores the application of biomass seed oil to produce a renewable fuel (biodiesel) using heterogeneous base catalyst. Meanwhile, two-step processes were employed to produce the biofuel. In the first step (esterification), the acid value of the oil was reduced to the recommended limit (FFA ≤ 1.5) using H2SO4, while in the second step (transesterification), the catalyst calcination of grounded Brette Pearl Spar Mable (BPSM) pre-soaked in methanol was used as a biobase for biodiesel production. For the optimization, minitab response surface (MRS) and artificial neural network (ANN) were employed to model and optimize the process variables responsible for the optimum production of the oil and the biodiesel.

Results
The result presented showed that T. peruviana seed was found to be rich in oil with an average yield of 44.00% (w/w), and the oil was highly unsaturated with a high FFA. The maximum experimental biodiesel yield obtained was 86.00% at a catalyst amount of 4 g, a reaction time of 70 min, and a methanol/oil ratio of 0.1(v/v). This result was validated in triplicate under the same conditions, which yielded 85.70% (v/v) for MRS and 85.98% (v/v) for ANN. Furthermore, the optimization results also indicated that the p values (p < 0.05) of the model terms were significant, and the accuracy of the models achieved by MRS and ANN based on R2 depict that both optimization tools gave good predictions of R2 (MRS: R2 = 99.98% and ANN: R2 = 99.97%). The properties of the biodiesel, as described in other earlier reports using the same feedstock with different catalysts, indicated that the produced biodiesel had properties which agreed to those reported in the literature.

Conclusions
T. peruviana seed has proved to be a good biomass raw material for oil production, and its conversion to biofuel using a heterogeneous biobase catalyst showed its suitability as a renewable environmental friendly fuel. Government should invest in more sustainable sources of energy by imposing law for the use of non-edible oil or decreasing the price of electricity.
Induction Chemotherapy Followed by Cetuximab Radiotherapy Is Not Superior to Concurrent Chemoradiotherapy for Head and Neck Carcinomas: Results of the GORTEC 2007-02 Phase III Randomized Trial
Authors: Geoffrois Lionnel , Martin Laurent , De Raucourt Dominique , Sun Xu Shan , Tao Yungan , Maingon Philippe , Buffet Joëlle , Pointreau Yoann , Sire Christian , Tuchais Claude , Babin Emmanuel , Coutte Alexandre , Rolland Frédéric , Kaminsky Marie-Christine , Alfonsi Marc , Lapeyre Michel , Saliou Marie , Lafond Cédric , Jadaud Eric , Gery Bernard , Zawadi Ayman , Tourani Jean-Marc , Khoury Cédric , Henry Anne Rose , Hasbini Ali , Guichard François , Borel Christian , Meert Nicolas , Guillet Pierre , Calais Marie-Hélène , Garaud Pascal , Bourhis Jean 
Published: July 2018

Purpose Both concurrent chemoradiotherapy (CT-RT) and cetuximab radiotherapy (cetux-RT) have been established as the standard of care for the treatment of locally advanced squamous cell carcinoma of the head and neck. It was not known whether the addition of induction chemotherapy before cetux-RT could improve outcomes compared with standard of care CT-RT. Patients and Methods The current trial was restricted to patients with nonmetastatic N2b, N2c, or N3 squamous cell carcinoma of the head and neck and fit for taxotere, cisplatin, fluorouracil (TPF). Patients were randomly assigned to receive three cycles of TPF followed by cetux-RT versus concurrent carboplatin fluorouracil and RT as recommended in National Comprehensive Cancer Network guidelines. The trial was powered to detect a hazard ratio (HR) of 0.66 in favor of TPF plus cetux-RT for progression-free survival at 2 years. The inclusion of 180 patients per arm was needed to achieve 80% power at a two-sided significance level of .05. Results Between 2009 and 2013, 370 patients were included. All patients and tumors characteristics were well balanced between arms. There were more cases of grade 3 and 4 neutropenia in the induction arm, and the induction TPF was associated with 6.6% treatment-related deaths. With a median follow-up of 2.8 years, 2-year progression-free survival was not different between both arms (CT-RT, 0.38 v TPF + cetux-RT, 0.36; HR, 0.93 [95% CI, 0.73 to 1.20]; P = .58). HR was 0.98 (95% CI, 0.74 to 1.3; P = .90) for locoregional control and 1.12 (95% CI, 0.86 to 1.46; P = .39) for overall survival. These effects were observed regardless of p16 status. The rate of distant metastases was lower in the TPF arm (HR, 0.54 [95% CI, 0.30 to 0.99]; P = .05). Conclusion Induction TPF followed by cetux-RT did not improve outcomes compared with CT-RT in a population of patients with advanced cervical lymphadenopathy.
Sirolimus for Secondary Prevention of Skin Cancer in Kidney Transplant Recipients: 5-Year Results
Authors: Dantal Jacques , Morelon Emmanuel , Rostaing Lionel , Goffin Eric , Brocard Anabelle , Tromme Isabelle , Broeders Nilufer , del Marmol Véronique , Chatelet Valérie , Dompmartin Anne , Kessler Michèle , Serra Andreas , Hofbauer Günther F.L. , Kamar Nassim , Pouteil-Noble Claire , Kanitakis Jean , Roux Adeline , Decullier Evelyne , Euvrard Sylvie ,   TUMORAPA Study Group
Published: July 2018

PurposeTransplant recipients who develop cutaneous squamous cell carcinomas are at high risk for multiple subsequent skin cancers. Sirolimus has been shown to reduce the occurrence of secondary skin cancers, but no study included a follow-up exceeding 2 years. We extended at 5 years the TUMORAPA randomized trial of sirolimus-based immunosuppressive regimen versus calcineurin inhibitor–based immunosuppression.MethodsKidney transplant recipients receiving calcineurin inhibitors who had at least one cutaneous squamous cell carcinoma were randomly assigned to receive sirolimus as a substitute for calcineurin inhibitors (n = 64) or to maintain their initial treatment (n = 56). The primary end point was survival free of squamous cell carcinoma at 5 years. Secondary end points included the occurrence of other skin cancers, renal function, patient and graft survival, and treatment tolerance.ResultsSurvival free of cutaneous squamous cell carcinoma was significantly longer in the sirolimus group than in the calcineurin inhibitor group ( P = .007). In the sirolimus group, the number of patients with new skin cancers was significantly lower compared with the calcineurin inhibitor group: 22% versus 59% for squamous cell carcinomas ( P < .001), 34% versus 66% for other skin cancers ( P < .001), and 20% versus 37.5% for basal cell carcinomas ( P < .05). Kidney graft function, patients, and graft survival were similar in both groups. In the sirolimus group, the mean number of serious adverse effects per patient decreased from 1.16 during the first 2 years, to 0.83 between years 2 and 5.ConclusionIn kidney transplant recipients with previous cutaneous squamous cell carcinomas, the antitumoral effect of conversion from calcineurin inhibitors to sirolimus was maintained at 5 years, and sirolimus tolerance was satisfactory.