bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retextualisation through Contextualisation
Authors: Holtzhauer Sebastian 
Published: December 2018

Abstract
On the basis of Cod. pal. germ. 60 (ub Heidelberg) the author shows how strategies and concepts for the arrangement of texts in medieval manuscripts can call forth and highlight certain connotations of the separate texts in a manuscript. Several texts and their included illustrations in this manuscript, among them a prose version of ‘The Voyage of Saint Brendan’, and also a German translation of the ‘Tractatus de purgatorio Sancti Patricii’, by their interference point at a ‘Narrative of the Purgatory’, which is spread like a net over the entire manuscript. Consequently, the interpretation goes beyond the usual textual analysis of the works and asks for retextualisation within the framework of a concrete manuscript context, and therefore also for their ‘status in life’. Central in the research are the strategies of legitimization of fictional contents, which take the codex into account as the communicator of text and illustrations and so draw the reality of the recipients into it, by which they are drawn into the narrated world.
A New Parameterization of the Accretion of Cloud Water by Graupel and Its Evaluation through Cloud and Precipitation Simulations
Authors: Jin Han-Gyul , Lee Hyunho , Baik Jong-Jin 
Published: December 2018

Abstract
A new parameterization of the accretion of cloud water by graupel for use in bulk microphysics schemes is derived by analytically integrating the stochastic collection equation (SCE). In this parameterization, the collection efficiency between graupel particles and cloud droplets is expressed in a functional form using the data obtained from a particle trajectory model by a previous study. The new accretion parameterization is evaluated through box model simulations in comparison with a bin-based direct SCE solver and two previously developed accretion parameterizations that employ the continuous collection equation and a simplified SCE, respectively. Changes in cloud water and graupel mass contents via the accretion process predicted by the new parameterization are closest to those predicted by the direct SCE solver. Furthermore, the new parameterization predicts a decrease in the cloud droplet number concentration that is smaller than the decreases predicted by the other accretion parameterizations, consistent with the direct SCE solver. The new and the other accretion parameterizations are implemented into a cloud-resolving model. Idealized deep convective cloud simulations show that among the accretion parameterizations, the new parameterization predicts the largest rate of accretion by graupel and the smallest rate of accretion by snow, which overall enhances rainfall through the largest rate of melting of graupel. Real-case simulations for a precipitation event over the southern Korean Peninsula show that among the examined accretion parameterizations, the new parameterization simulates precipitation closest to observations. Compared to the other accretion parameterizations, the new parameterization decreases the fractions of light and moderate precipitation amounts and increases the fraction of heavy precipitation amount.
Transient binocular blindness: A rare presentation of aortic dissection
Authors: Shaharudin Abdul Hafiz , Ab Hamid Muhamad Hafiq , Yahaya Rosliza , Nik Him Nik Ahmad Shaiffudin , Nik Mohamed Nik Arif , Wan Jusoh Azizul Fadzli 
Published: December 2018

Introduction: Aortic dissection is a clinical chameleon that can have variable presenting features that require a careful history and physical examination. A non-specific presentation of this life-threatening condition causes a diagnostic dilemma among clinicians especially in the emergency department leading to grave consequences. Case Presentation: We present a case of aortic dissection that presented as an acute bilateral blindness that was associated with a sudden onset of loss of consciousness and central chest pain. Bedside carotid ultrasound showed a double lumen carotid artery suggesting an intraluminal flap. Computed tomography angiography revealed extensive dissection of the entire length of the aorta. Discussion: This case illustrated the need for a high index of suspicion to diagnose patients with aortic dissection especially as the patient presented with an acute binocular visual loss and chest pain. Conclusion: A bedside carotid artery ultrasound in the emergency department was found useful in screening and diagnosing a carotid artery–related pathology.
Cardiac troponin I in cats with compromised renal function
Authors: Langhorn Rebecca , Jessen Lisbeth R , Kloster Anne S , Jensen Anders P , Koch Jørgen 
Published: December 2018

Objectives Cardiac troponins are sensitive and specific markers of myocardial injury. However, their reliability in renal disease has been questioned owing to possible renal involvement in troponin elimination. The primary objective of the present study was to examine whether serum cardiac troponin I is elevated in cats with compromised renal function and no clinically relevant structural cardiac disease. A secondary objective was to examine whether cardiac troponin I is measurable in the urine of cats with normal and compromised renal function. Methods This prospective case-control study included 52 cats (19 with compromised renal function, 19 with primary cardiac disease and 14 healthy controls). For all cats, clinical examination, echocardiography, electrocardiography, blood pressure, complete blood count, biochemistry, serum thyroxine and urinalysis were performed. Cardiac troponin I was measured in the serum and urine of each cat. Results Median (range) serum cardiac troponin I concentrations were 0.052 ng/ml (0.015–0.78 ng/ml) for the renal group, 0.083 ng/ml (0.003–3.27 ng/ml) for the cardiac group and 0.012 ng/ml (0.003–0.14 ng/ml) for the control group. The renal and cardiac groups both had significantly higher serum cardiac troponin I concentrations than the control group, whereas no difference could be detected between the renal and cardiac groups. In the renal group 7/19 cats had measurable urine cardiac troponin I, whereas cardiac troponin I was measurable in the urine of one cat in the cardiac group and two healthy controls. There was no significant correlation between serum and urine cardiac troponin I. Conclusions and relevance Elevated serum cardiac troponin I in cats with compromised renal function may occur without evidence of clinically relevant structural cardiac disease. Moreover, detecting cardiac troponin I in urine is most likely in cats with compromised renal function.
Statin use is associated with less postoperative cardiac arrhythmia after total hip arthroplasty
Authors: Chen Michael J , Bala Abiram , Huddleston James I , Goodman Stuart B , Maloney William J , Aaronson Alistair J , Amanatullah Derek F 
Published: December 2018

Introduction: While statins have been found to reduce postoperative atrial fibrillation after cardiac surgery, little is known about their use in total hip arthroplasty (THA). This study investigated if statins would similarly reduce postoperative arrhythmias in patients undergoing THA. Methods: We queried a large Medicare and private-payer database from 2005 to 2012 and identified 12,075 patients who were on a statin prior to THA. We then age and sex matched 34,446 non-statin users who underwent THA. Baseline comorbidities and postoperative complications were obtained and assessed via standard descriptive statistics. Results: The statin users had more preoperative comorbidities including congestive heart failure, valvular heart disease, pulmonary and renal disease, diabetes, hypertension, obesity, and anaemia (all p values < 0.001). Postoperatively, the statin users had a statistically higher 90-day incidence of transfusion, acute renal failure, heart failure, pneumonia, and sepsis/shock. All new-onset cardiac arrhythmia was significantly less frequent in the statin group at 2 weeks (3.88% vs. 4.72%, p < 0.001), 30 days (4.47% vs. 5.29%, p < 0.001), and 90 days (5.44% vs. 6.31%, p = 0.001) postoperative. There was no difference in the frequency of venous thromboembolism, myocardial infarction, postoperative anaemia, or bleeding at 90 days postoperative. Discussion: Despite being medically sicker at baseline with multiple risk factors for atrial fibrillation compared to the non-statin users, the statin users displayed a consistently lower occurrence of postoperative cardiac arrhythmia in this retrospective cohort study. Statins may therefore be beneficial in the preoperative optimisation of medically complex patients undergoing THA.
Submicron Filtration Media
Authors: Shields Christopher 
Published: December 2018

Biopharmaceutical processes, membrane pretreatment, water purification and food and beverage applications all require fine filtration. There are many different types of filter media that can be used for these applications. The types of media vary by materials of construction, processing method and performance characteristics. Each process produces a media with unique properties that have advantages in different applications. These industries have traditionally relied on membranes for their submicron filtration needs. Nonwoven media have not been successful in finer filtration applications due to the relatively large fibers that are produced or the technical and/or operational difficulties in producing fine fiber media. A significant amount of research has been expended over the last few years on developing high efficiency wetlaid media and producing fine diameter synthetic fibers in drylaid operations. Nonwoven media have begun to compete with membranes and other separation technologies in these fine filtration applications. High efficiency nonwoven media composites have equivalent efficiency as many types of membranes but with significantly higher dirt holding capacity or life. This paper will discuss the different types of wetlaid, drylaid and membrane media available for submicron filtration and compare their methods of construction, performance and cost.
Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma
Authors: Mohanty Atish , Sandoval Natalie , Phan An , Nguyen Thang V. , Chen Robert W. , Budde Elizabeth , Mei Matthew , Popplewell Leslie , Pham Lan V. , Kwak Larry W. , Weisenburger Dennis D. , Rosen Steven T. , Chan Wing C. , Müschen Markus , Ngo Vu N. 
Published: December 2018

Abstract
The neural transcription factor SOX11 is usually highly expressed in typical mantle cell lymphoma (MCL), but it is absent in the more indolent form of MCL. Despite being an important diagnostic marker for this hard-to-treat malignancy, the mechanisms of aberrant SOX11 expression are largely unknown. Herein, we describe 2 modes of SOX11 regulation by the cell-cycle regulator cyclin D1 (CCND1) and the signal transducer and activator of transcription 3 (STAT3). We found that ectopic expression of CCND1 in multiple human MCL cell lines resulted in increased SOX11 transcription, which correlated with increased acetylated histones H3K9 and H3K14 (H3K9/14Ac). Increased H3K9/14Ac and SOX11 expression was also observed after histone deacetylase 1 (HDAC1) or HDAC2 was depleted by RNA interference or inhibited by the HDAC inhibitor vorinostat. Mechanistically, we showed that CCND1 interacted with and sequestered HDAC1 and HDAC2 from the SOX11 locus, leading to SOX11 upregulation. Interestingly, our data revealed a potential inverse relationship between phosphorylated Y705 STAT3 and SOX11 expression in MCL cell lines, primary tumors, and patient-derived xenografts. Functionally, inactivation of STAT3 by inhibiting the upstream Janus kinase (JAK) 1 or JAK2 or by STAT3 knockdown was found to increase SOX11 expression, whereas interleukin-21 (IL-21)–induced STAT3 activation or overexpression of the constitutively active form of STAT3 decreased SOX11 expression. In addition, targeting SOX11 directly by RNA interference or indirectly by IL-21 treatment induced toxicity in SOX11+ MCL cells. Collectively, we demonstrate the involvement of CCND1 and STAT3 in the regulation of SOX11 expression, providing new insights and therapeutic implications in MCL.
The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma
Authors: Runckel Kyle , Barth Matthew J. , Mavis Cory , Gu Juan J. , Hernandez-Ilizaliturri Francisco J. 
Published: December 2018

Abstract
Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) family proteins. Here, we provide evidence to support pharmacologically targeting IAPs in lymphoma with LCL-161, a small molecule mimetic of the second mitochondria-derived activator of caspases (SMAC). The antitumor effect of LCL-161 was determined using luminescent adenosine triphosphate assays, flow cytometry, SCID mouse xenografts, and ex vivo patient biopsy sample studies. In vitro exposure to LCL-161 also resulted in a dose-dependent decrease in IAP levels, along with synergistic enhancement of the antitumor effect of cytotoxic chemotherapy, in rituximab-sensitive cell lines and RRCLs. In addition, LCL-161 increased the cytotoxic effect of the proteasome inhibitor carfilzomib in ex vivo lymphoma patient samples. The combination of LCL-161 with the chemotherapy regimen rituximab, gemcitabine, and vinorelbine (RGV) improved in vivo survival compared with RGV alone in severe combined immunodeficient mice implanted with RRCLs but not in animals implanted with rituximab-sensitive cell lines. In summary, LCL-161 exhibits synergistic antitumor activity in both in vitro and in vivo models of resistant lymphoma. Our data support further preclinical investigation of LCL-161 as a novel antilymphoma agent.
Drinking vessel preferences in older nursing home residents: optimal design and potential for increasing fluid intake
Authors: Bak Aggie , Wilson Jennie , Tsiami Amalia , Loveday Heather 
Published: December 2018

Background: residents in nursing and residential care homes are at risk of dehydration due to both resident and institutional factors. Previous studies have focused on improving fluid intakes by concentrating on types of fluids offered and assisting residents to drink. Aim: to determine resident opinion of the optimal features of drinking vessels and evaluate the impact of improving vessel design on fluid consumption. Methods: residents from two units (25-bed and 21-bed) in one nursing home evaluated a range of drinking vessels. Vessels with preferred features were introduced on a 25-bed unit. The effect was tested by observing residents' fluid consumption during breakfast on three consecutive days and comparing with baseline intakes. Findings: vessels that received the highest ratings were lightweight, had large handles and held 200–300 ml of fluid. Following the introduction of the new drinking vessels, mean fluid intakes at breakfast increased from 139 ml (±84 ml) to 205 ml (±12 ml, n=65), p=0.003. Conclusion: some drinking vessels used in nursing homes may be difficult for residents to handle. Making improvements to the design of drinking vessels has the potential to increase fluid intakes without increasing staff workload.
6-8. Sınıf Üstün Yetenekli Öğrencilerin Problem Çözerken Sergiledikleri Üst Bilişsel Beceriler: Gümüşhane Örneği
Authors: ÖZTÜRK Mesut , AKKAN Yaşar , KAPLAN Abdullah 
Published: December 2018

Üstün yetenekli öğrencilerin üst bilişsel becerilerini kullanarak problem çözmeleri, öğrencilerin matematik kavramlarına yönelik ilişki kurmasını güçlendirerek, matematiksel anlamalarını ve matematiği derinlemesine öğrenmelerini geliştirecektir. Bu nedenle çalışmanın amacı 6-8. sınıf üstün yetenekli öğrencilerin problem çözerken sergiledikleri üst bilişsel becerileri belirlemek ve karşılaştırmaktır. Çalışmada nitel araştırma desenlerinden durum çalışması yöntemi kullanılmıştır. Üstün yetenekli dokuz ortaokul öğrencisiyle yürütülen bu çalışmada veriler, sesli düşünme protokolü (görüşme formları) ve gözlem formları kullanılarak toplanmıştır. Alan yazıdaki çalışmalardan yararlanılarak tematik analiz yapılmıştır. Çalışmanın sonucunda farklı öğrenim seviyesindeki üstün yetenekli öğrencilerin problem çözme basamaklarının tamamında üst bilişsel beceri sergiledikleri, öğrencilerin öğrenim seviyesi arttıkça problem çözme süreçlerinde sergiledikleri üst bilişsel becerilerin sayısının genel olarak arttığı belirlenmiştir. Bunula birlikte problem çözme basamaklarının tümünde öğrencilerin genel olarak kendilerine güvendikleri, hedeflerini (tekrar) gözden geçirdikleri ve her basamakta kendilerini değerlendirdikleri/kontrol ettikleri tespit edilmiştir.
Focus 20 - décembre 2016
Authors: Van der Linden Bruno 
Published: December 2018

Selon les projections économiques de l’automne 2016 réalisées par la BNB, l’emploi en Belgique a augmenté de 116.000 unités sur la période 2014-2016. Le gouvernement fédéral s’est empressé d’y voir une illustration du succès de sa politique. Ce que notamment l’Institut pour un développement durable a «mis en perspective».
Se faire une opinion quant au lien entre l’action de tel gouvernement et nos performances d’emploi est un exercice critiquable si l’évolution observée n’est pas comparée à la construction d’une situation de référence de qualité. Celle-ci doit mesurer ce qu’il serait advenu à l’emploi chez nous en l’absence de l’action du gouvernement concerné. La construction de cette situation de référence est indispensable. Elle est aussi un défi, souvent mal relevé.
Point-of-care haemostasis monitoring during liver transplantation is cost effective
Authors: Leon-Justel Antonio , Alvarez-Rios Ana I. , Noval-Padillo Jose A. , Gomez-Bravo Miguel A. , Porras Manuel , Gomez-Sosa Laura , Lopez-Romero Juan L. , Guerrero Juan M. 
Published: December 2018

Abstract

Background
Optimal haemostasis management in orthotropic liver transplant (OLT) could reduce blood loss and transfusion volume, improve patient outcomes and reduce cost.

Methods
We performed a study including 336 OLTs to evaluate the clinical and cost effectiveness of a new point-of-care (POC)-based haemostatic management approach in OLT patients.

Results
In terms of health benefit we found that the new approach showed a significant reduction in transfusion requirements (red blood cell transfusion units were reduced from 5.3±4.6 to 2.8±2.9 [p<0.001], free frozen plasma from 3.1±3.3 to 0.4±1.0 [p<0.001] and platelets from 2.9±3.9 to 0.4±0.9 [p<0.001], transfusion avoidance, 9.7% vs. 29.1% [p<0.001] and massive transfusion, 14.5% vs. 3.8% [p=0.001]); we also found a significant improvement in patient outcomes, such, reoperation for bleeding or acute-kidney-failure (8.3% vs. 2.4%, p=0.015; 33.6% vs. 5.4%, p<0.001), with a significant reduction in the length of the hospital total stay (40.6±13.8 days vs. 38.2±14.4 days, p=0.001). The lowest cost incurred was observed with the new approach (€73,038.80 vs. €158,912.90) with significant patient saving associated to transfusion avoidance (€1278.36), ICU-stay (€3037.26), total-stay (€3800.76) and reoperation for bleeding (€80,899.64).

Conclusions
POC haemostatic monitoring during OLT is cost effective.
Hard Decisions Shape the Neural Coding of Preferences
Authors: Voigt Katharina , Murawski Carsten , Speer Sebastian , Bode Stefan 
Published: December 2018

Hard decisions between equally valued alternatives can result in preference changes, meaning that subsequent valuations for chosen items increase and decrease for rejected items. Previous research suggests that this phenomenon is a consequence of cognitive dissonance reduction after the decision, induced by the mismatch between initial preferences and decision outcomes. In contrast, this functional magnetic resonance imaging and eye-tracking study with male and female human participants found that preferences are already updated online during the process of decision-making. Preference changes were predicted from activity in left dorsolateral prefrontal cortex and precuneus while making hard decisions. Fixation durations during this phase predicted both choice outcomes and subsequent preference changes. These preference adjustments became behaviorally relevant only for choices that were remembered and were in turn associated with hippocampus activity. Our results suggest that preferences evolve dynamically as decisions arise, potentially as a mechanism to prevent stalemate situations in underdetermined decision scenarios.SIGNIFICANCE STATEMENTMost theories of decision-making assume that we always choose the best option available, based on a set of stable preferences. However, what happens for hard decisions when the available options are preferred equally? We show that in such stalemate situations, decision-makers adjust their preferences dynamically during the process of decision-making, and these preference adjustments are predicted by a left prefrontal-parietal network. We also show that eye movements during decision-making are predictive of the magnitude of the upcoming value change. Our results suggest that preferences are dynamic, adjusted every time a hard decision is made, prompting a re-evaluation of existing frameworks of decision-making.
Sınıf II Aktivatör İle Tedavi Edilmiş Bireylerde Havayolu Değişikliklerinin İncelenmesi
Authors: Sayar Gülşilay , Kılınç Delal Dara 
Published: December 2018

Amaç: Bu
çalışmanın amacı fonksiyonel ortopedik tedavi gören bireylerde Andresen
aktivatörünün havayolu üzerine etkisini
kontrol grubu ile karşılaştırmalı olarak değerlendirmektir.

Gereç ve Yöntemler:Çalışmaya
büyümesi devam eden iskeletsel Sınıf II
maloklüzyona sahip aktivatör ile tedavi edilen 19 birey tedavi grubu, sabit
fonksiyonel ortopedik tedavi öncesi ortodontik tedavisi yapılacak ve
gözlenmekte olan 19 adet iskeletsel Sınıf II birey kontrol grubu olarak
katılmıştır. Bu hastalardan elde edilen lateral sefalometrik filmler üzerinde
ölçümler gerçekleştirilmiştir. Normal dağılım gösteren verilerin
karşılaştırılmasında bağımsız örnek t testi ile eşli örnek t testi kullanıldı.
Normal dağılım göstermeyen verilerin karşılaştırılmasında ise Mann Whitney U
testi kullanıdı. Anlamlılık düzeyi
p&lt;0,05 olarak alındı.

Sonuçlar:Aktivatör
kullanımı ile üst ve alt havayolunda tedavi öncesi ile tedavi sonrası arasında
anlamlı artış bulunmasına rağmen, kontrol grubu ile aralarında anlamlı
farklılık bulunmamıştır.

Anahtar Kelimeler:Aktivatör,
Sınıf II maloklüzyon, Ortodonti, Havayolu
Redes sociales y estudiantes: motivos de uso y gratificaciones. Evidencias para el aprendizaje
Authors: García-Ruiz Rosa , Tirado Morueta Ramón , Hernando Gómez Angel 
Published: December 2018

Aunque las nuevas generaciones utilizan las redes sociales como un medio de comunicación habitual, en el ámbito educativo aún no se han utilizado de manera generalizada por los docentes como recurso didáctico. Conocer las gratificaciones que encuentran las nuevas generaciones al usar las redes sociales, permitirá al profesorado hacer un uso estimulante de estos medios en la educación secundaria y universitaria. El objetivo de este trabajo es conocer cuáles son las gratificaciones que encuentran los estudiantes de educación secundaria y universitaria al utilizar intensamente las redes sociales Facebook, Instagram y YouTube. Utilizando la teoría de Usos y Gratificaciones, se recogen datos a través de un cuestionario de estudiantes españoles de educación secundaria (N=260) y universitarios (N=315). Los resultados muestran que los estudiantes de secundaria buscan una mayor presencia social y velan por su propia imagen, mientras que los estudiantes universitarios buscan entretenimiento. Finalmente, se discuten los resultados y las implicaciones para un uso estimulante y didáctico de las redes sociales en contexto de enseñanza-aprendizaje.