bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quiescent Infections ofElephant Endotheliotropic HerpesvirusesandElephant GammaherpesvirusesDetected in African Elephants in Botswana, Gabon, Kenya, South Africa and USA
Authors: Pearson Virginia Riddle , Hayward Gary S. 
Published: November 2024

ABSTRACTIn this study, initiated in 2009, quiescent infections ofAfrican Elephant Endotheliotropic Herpesviruses (EEHVs)EEHV2, EEHV3A, EEHV3B, EEHV6, EEHV7AandEEHV7B, that can cause lethalElephant Hemorrhagic Disease(EHD)andAfrican Elephant Gammaherpesviruses (EGHVs) EGHV1B, EGHV2, EGHV3B, EGHV4BandEGHV5B, that are not associated with severe morbidity, were detected in African elephants,Loxodonta africanaandLoxodonta cyclotis, in Africa and USA. We genetically evaluated trunk fibropapillomas (nodules), saliva, blood and tissues collected from 43 wildLoxodonta africana(African savannah elephants) in Botswana, Kenya and South Africa; saliva received from 25 wildLoxodonta cyclotis(African forest elephant) in Gabon; and saliva collected over a seven year period from 7 wild-bornLoxodonta africana(6 from Uganda and 1 from Zimbabwe) residing in Six Flags Safari Park in Jackson, NJ, USA, and saliva, blood and tissues collected from an additional 200Loxodonta africanaand 100Elephas maximus(Asian elephant) in USA. DNA was extracted and amplified by conventional PCR (cPCR) using three-round nested primer sets targeting manyAfrican Elephant EEHVsgenes loci and primers designed specifically to recognizeAfrican Elephant EGHVsspecies. Sanger sequencing yielded unambiguous positive genetic matches to knownAfrican Elephant EEHV2, EEHV3A, EEHV6,EEHV7A, EGHV1B, EGHV2, EGHV3B, EGHV4B, EGHV5Band discovered novel species includingEEHV3B, rare subtypesEEHV3C to EEHV3HandEEHV7B, and the prototypeAfrican Elephant EGHV1B. Our extensive library of elephant viral sequences and genomic DNA samples are invaluable assets for development of vaccines againstEHDand for conserving genomic diversity in dwindling herds in situ and isolated herds in preserves and zoos worldwide.
Chromosome engineering to restore euploidy in cells harboring a complex rearrangement of chromosome 8
Authors: Lee Sophia N. , Qiao Lu , Thompson Sarah L. , Hagenson Ryan A. , Davoli Teresa , Sheltzer Jason M. 
Published: November 2024

AbstractChromosomal rearrangements on the short arm of chromosome 8 cause 8p syndrome, a rare developmental disorder characterized by neurodevelopmental delays, epilepsy, and cardiac abnormalities. While significant progress has been made in managing the symptoms of 8p syndrome and other conditions caused by large-scale chromosomal aneuploidies, no therapeutic approach has yet been demonstrated to target the underlying disease-causing chromosome. Here, we establish a two-step approach to eliminate the abnormal copy of chromosome 8 and restore euploidy in cells derived from an individual with a complex rearrangement of chromosome 8p. Transcriptomic analysis revealed 361 differentially expressed genes between the proband and the euploid revertant, highlighting genes both within and outside the 8p region that may contribute to 8p syndrome pathology. Our work demonstrates the feasibility of using chromosome engineering to correct complex aneuploidies in vitro and suggests a potential therapeutic avenue for disorders caused by chromosomal rearrangements.
Time affects a time-consuming, flexible component and a fast, inflexible component of sensorimotor adaptation
Authors: Leow Li-Ann , Marinovic Welber , Albert Scott , Carroll Timothy J 
Published: November 2024

AbstractPrior learning can impair future learning when the requirements of the two memories conflict, a phenomenon termed anterograde interference. In sensorimotor adaptation, the passage of time between initial and future learning can reduce such interference effects. However, we still do not fully understand how time affects learning, as some studies found no effects of time on interference. One possible explanation for such inconclusive findings is that time affects distinct processes underpinning sensorimotor adaptation differently, and these processes may compensate for each other’s effects on behaviour. Here, we used task manipulations that (1) dissociate adaptation processes driven by task errors from adaptation processes driven by sensory prediction errors, and (2) separate the task-error driven adaptation processes into a flexible component that could not be acquired under time-pressure, or a less-flexible component that could not be acquired under time-pressure. The time between initial and subsequent learning seemed to alter both the flexible and inflexible components of adaptation driven by task errors. Time also led to a small reduction of interference arising from sensory prediction errors. Thus, we provide evidence that multiple components of sensorimotor adaptation are sensitive to the passage of time.
Glutamate receptor-dependent cytosolic acidification in hippocampal neurons involves passive flux of protons from the extracellular space
Authors: Pedersen Sofie E. , Konomi-Pilkati Ainoa , Hansen Nikolaj W. , Kvist Trine , Posselt Leonie P. , Andreassen Thorvald F. , Sørensen Andreas T. , Perrier Jean François , Madsen Kenneth L. 
Published: November 2024

AbstractGlutamate receptor-dependent cytosolic acidification can be induced in hippocampal neurons by pharmacological or seizure-like stimulation. This acidification is thought to arise from Ca2+and metabolism-related processes, however, the exact underlying mechanism as well as its functional role remains uncertain. To reassess the mechanism of cytosolic acidification in excitatory hippocampal neurons and address the physiological relevance of the phenomenon, we combined pH/Ca2+biosensors to study activity-induced pH dynamics in hippocampal neurons. First, we addressed cytosolic acidification in relation to LTP at hippocampal CA3-CA1 synapses. Using hippocampal slices from adult rats of both sexes, we show that LTP-inducing stimulation at the Schaffer collaterals evokes transient cytosolic acidification in hippocampal CA1 neurons. This highlights neuronal pH shifts as a trait of general hippocampal neurotransmission rather than a marker of excitotoxicity, possibly serving as a secondary messenger. Moreover, using dissociated hippocampal neurons from rat embryos, we show that glutamate receptor agonists typically induce larger cytosolic acid shifts compared to simple depolarization or spontaneous activity, suggesting that glutamate receptor-mediated acidification involves several separate mechanisms; pyruvate-dependent dampening of neuronal acidification may reflect a direct inhibition of NMDA receptors rather than reduced glycolytic activity, questioning the previously reported involvement of metabolism in cytosolic acidification; and whereas acid shifts induced by simple depolarization show exclusive dependence on cytosolic Ca2+, AMPA-induced acidification depends both on cytosolic Ca2+andon an inward electrochemical driving force for protons. These results suggest that glutamate receptor-induced cytosolic acidification relies both on cytosolic Ca2+and on a passive proton influx, possibly mediated by the receptor itself.Graphical abstractSignificance statementAlthough several studies report that hippocampal pyramidal neurons show significant cytosolic acidification in response to activation by drugs, epilepsy and stroke, the molecular mechanism and functional impact of the phenomenon remains uncertain. Using live imaging of both Ca and H dynamics, we demonstrate that the induction of LTP at hippocampal synapses is associated with cytosolic acidification in the postsynaptic neurons, suggesting that the cytosolic acid shifts may be a general trait of neurotransmission and related plasticity. We further revisit the mechanistic relation between the two ion systems. Our results suggest that glutamate receptor-induced cytosolic acidification involves two distinct mechanisms, one related to cytosolic Ca and another involving a passive H influx, possibly mediated by the receptor itself.
A Protocol for Adapting a Mindfulness-Based Intervention with Contingency Management to Reduce Alcohol Misuse Among Latine Emerging Adults
Authors: Hospital Michelle M , Alessi Sheila , Contreras Perez Maria Eugenia , Langwerden Robbert , Perez Katherine R , Quintana Jordan , Morris Staci Leon , Castellanos Gus , Fernandez Sofia B , Wagner Eric F 
Published: November 2024

AbstractEmerging adulthood (ages 18-25 years old) is a critical period for the onset of problematic drinking, especially within underserved populations, such as Latine emerging adults. This protocol outlines the adaptation of a Mindfulness-Based Intervention (MBI) incorporating Contingency Management (CM) to address alcohol misuse in Latine young adults, a demographic with limited treatment access and increased vulnerability to substance use disorders. Grounded in Community-Engaged Research (CEnR) principles, this study employs a structured formative development approach to culturally and developmentally adapt a Mindfulness-Based Stress Reduction (MBSR) program. The intervention is designed to enhance emotional regulation and reduce alcohol misuse, supported by CM strategies to boost participant retention. This study’s objectives include assessing the feasibility, acceptability, and initial efficacy of the adapted MBI among non-treatment-seeking Latine emerging adults engaging in heavy episodic drinking. If successful, this protocol will provide a culturally resonant, non-traditional intervention model to mitigate alcohol misuse within this high-need population and inform future preventive efforts.
Exploring optimal sensitivity of lepton flavor violating effective couplings at the
e+e−
colliders
Authors: Jahedi Sahabub , Sarkar Abhik 
Published: November 2024

We analyze lepton flavor violation (LFV) using the Standard Model effective field theory (SMEFT) framework at the future lepton colliders. Our focus is on the associated production of tau lepton with electron/muon at the electron-positron (e+e−) colliders, related to four-Fermi SMEFT effective operators. In accordance with the upper limits on effective couplings from lepton flavor violating tau decays, we conduct a cut-based analysis to achieve sufficient signal significance. We utilize the optimal observable technique (OOT) to estimate the optimal sensitivity of the effective couplings. The impact of electron beam polarization and the interplay of signal and background in enhancing the optimal sensitivity of the effective couplings are discussed in detail. We find that the sensitivity of flavor-violating effective couplings is enhanced by order of one for 3 TeV center-of-mass (CM) energy and 1000  fb−1 integrated luminosity at the e+e− colliders.

Published by the American Physical Society
2024
How are regions using European funds to promote the circular economy? Shedding light on factors explaining the pathway
Authors: Barbero Javier , Rodríguez-Crespo Ernesto , M. Santos Anabela 
Published: November 2024

Purpose
This study aims to examine the geographical spread of the EU-funded circular economy projects in the European Union.

Design/methodology/approach
The authors use a novel database of research and development projects funded by the European Regional Development Fund related to the circular economy to estimate a fractional response model on data for 231 European regions.

Findings
First, the authors detect a geographical pattern in the share of circular economy funds. Second, the authors find that institutional quality, employment, human capital and income may drive the concentration of circular economy research and development funds. Third, the authors find overall differences between technology projects and circular economy projects, suggesting that addressing the circular economy at the subnational level is complex.

Social implications
This work can be helpful to disseminate Sustainable Development Goals (SDGs). In particular, the authors pay special emphasis on SDGs numbers 11 (Sustainable Cities and Communities) and 13 (Climate Action).

Originality/value
The findings confirm the existence of a geographical spread of the circular economy, which may be useful to move toward regional sustainable development in the European Union.
Reliability analysis of (r,s)-out-of-n multi-state systems using copulas
Authors: Erem Halilsoy Aysegul , Iscioglu Funda 
Published: November 2024

PurposeThis study evaluates the reliability of a multi-state system (MSS) with n components, each having two s-dependent components via copulas.Design/methodology/approachThe study employs copula functions to model dependencies between components in an MSS. Specifically, it analyzes a (1,1)-out-of-n three-state system using Frank and Clayton copulas for reliability evaluation. A simulation-based case study of a micro-inverter solar panel system is also conducted using the Farlie–Gumbel–Morgenstern (FGM) copula.FindingsThe study finds that incorporating component dependencies significantly impacts the reliability of multi-state systems. Using Frank and Clayton copulas, the analysis shows how dependency structures alter system performance compared to independent models. The case study on a micro-inverter solar panel system, using the FGM copula, demonstrates that real-world systems with dependent components exhibit different performances. Also some effects of dependence parameters on the performance characteristics of the system such as mean residual lifetime and mean past lifetime are also examined.Originality/valueThis study is original in its use of copula functions to evaluate the performance of multi-state systems, particularly focusing on a (1,1)-out-of-n three-state system with dependent components. By applying Frank and Clayton copulas, the research advances reliability analysis by considering component dependencies, often overlooked in traditional models. Additionally, a case study on a micro-inverter solar panel system using the FGM copula highlights the practical application of these methods.
Triple-loop learning as a framework for advancing health systems science in medical education: a transformational change approach
Authors: Kwon Chang-kyu , Lee Andrew Sanghyun , An Soonok , Brandt Mary Catherine 
Published: November 2024

Purpose
The American Medical Association has recently adopted health systems science (HSS) as the third pillar of medical education to provide comprehensive and holistic patient care. The purpose of this paper is to propose a novel organizational learning perspective in considering how medical schools can facilitate a transformational HSS curriculum change.

Design/methodology/approach
This is a conceptual paper seeking to present triple-loop learning as a potential approach to HSS curriculum change.

Findings
Due to its potential for structural accountability and sustainability stemming from the inclusion of diverse voices, the authors argue that HSS curriculum change, guided by the principles of triple-loop learning, is likely to lead to the development of medical curricula that are more adaptive and responsive to the constantly changing health-care landscape. The authors advocate for the deliberate inclusion of stakeholders who have historically been excluded or marginalized in the HSS curriculum change process, such as patients and those in sentinel roles (e.g. nurses, social workers). The authors also suggest an integrated, multilevel transformation that involves collaboration among medical schools, accreditation organizations, licensing boards and health-care systems.

Originality/value
To the best of the authors’ knowledge, this paper represents the first attempt to apply the theory of triple-loop learning in the context of HSS curriculum change. It highlights how this critical systemic learning approach uniquely contributes to HSS curriculum change, and subsequently to the necessary, larger cultural changes demanded in medical education as a whole.
How does female representation affect long-term firm performance? Capturing causal complexity with a configurational approach
Authors: Tao Yan , Wang Huilin , He Jiaxi , Zhang Ziye , Liu Hong 
Published: November 2024

Purpose
Via dialectical perspective and configurational approach, this paper aims to explore the relationship between female representation and long-term firm performance when combined with environmental conditions.

Design/methodology/approach
For necessary condition analysis and time-series qualitative comparative analysis, a sample of 614 listed Chinese manufacturing firms between 2017 and 2020 was obtained.

Findings
The inclusion of female executives can aid firms in their long-term performance and resilience. Seven configurations, categorized as chimpanzee type, African elephant type and queen bee type, can prompt long-term firm performance. Chimpanzee-type configuration is the most prevalent path for firms to achieve long-term performance.

Practical implications
Firms could reconsider the role of female executives in achieving long-term success, assist in breaking the invisible “glass ceiling” and “glass cliff,” and refrain from viewing them as mere “tokens.” Policymakers can improve female representation by institutionally guaranteeing women’s opportunities for empowerment, education and promotion.

Originality/value
This study presents evidence for the legitimacy of female representation by demonstrating the intricate causality between female representation and firm performance beyond the controversy between business ethics and coercive policy. This paper also builds upon and extends the literature on female representation and provides alternative ways to improve female representation by combining female executives’ percentages, professionalism and positions.
Dual solutions of hybrid nanofluid flow past a permeable melting shrinking sheet with higher-order slips, shape factor and viscous dissipation effect
Authors: Abu Bakar Shahirah , Pop Ioan , Md Arifin Norihan 
Published: November 2024

Purpose
This paper aims to explore dual solutions for the flow of a hybrid nanofluid over a permeable melting stretching/shrinking sheet with nanoparticle shape factor, second-order velocity slip conditions and viscous dissipation. The hybrid nanofluid is formulated by dispersing alumina (Al2O3) and copper (Cu) nanoparticles into water (H2O).

Design/methodology/approach
The governing partial differential equations (PDEs) are first reduced to a system of ordinary differential equations (ODEs) using a mathematical method of similarity transformation technique. These ODEs are then numerically solved through MATLAB’s bvp4c solver.

Findings
Key parameters such as slip parameter, melting parameter, suction parameter, shrinking parameter and Eckert number are examined. The results reveal the existence of two distinct solutions (upper and lower branches) for the transformed ODEs when considering the shrinking parameter. Increasing value of Cu-volume fraction and the second-order velocity slip enhances boundary layer thicknesses, whereas the heat transfer rate diminishes with rising melting and suction parameters. These numerical results are illustrated through various figures and tables. Additionally, a stability analysis is performed and confirms the upper branch is stable and practical, while the lower branch is unstable.

Practical implications
The analysis of hybrid nanofluid flow over a shrinking surface has practical significance with applications in processes such as solar thermal management systems, automotive cooling systems, sedimentation, microelectronic cooling or centrifugal separation of particles. Both steady and unsteady hybrid nanofluid flows are relevant in these contexts.

Originality/value
While the study of hybrid nanofluid flow is well-documented, research focusing on the shrinking flow case with specific parameters in our study is still relatively scarce. This paper contributes to obtaining dual solutions specifically for the shrinking case, which has been less frequently addressed.
Analyzing critical success factors in Lean Six Sigma training
Authors: Paneerselvam Nithiaprathap , Muhammad Nur Amalina , Azhan Anis Masturina , Muhammad Noorhafiza 
Published: November 2024

PurposeThis study aims to assess the effectiveness of Lean Six Sigma (LSS) training by investigating critical success factors (CSFs) categorized into the domains of people, processes and technology.Design/methodology/approachA survey methodology, information was used to collect information from a participant pool of 102 individuals. The collected data were analyzed using ANOVA to examine the relationship between CSF and LSS training.FindingsOrganizing CSF significantly enhances the effectiveness of LSS training. High ratings were consistently observed for experienced instructors, structured materials and interactive elements. However, challenges were identified in evaluating the impact of training and the integration of e-learning platforms. These findings shed light on areas where improvements can be made to further enhance the outcomes of LSS training programs.Research limitations/implicationsThe sample size of 102 participants may limit the generalizability of the findings to a broader population. This study primarily examined short-term outcomes, so additional exploration of the long-term effects of LSS training is warranted. This research acknowledges potential bias in self-reported survey data and recognizes that personal perspectives may influence participant responses.Originality/valueThis research contributes a nuanced perspective by categorizing CSFs into the domains of people, process and technology, offering a comprehensive understanding of their interplay. Acknowledging the challenges in training evaluation and e-learning platforms adds originality to the study and provides practical insights for organizations aiming to optimize their LSS training initiatives.
The power of play and community – managing exercise at work by combining institutional logics
Authors: Wagner Ulrik , Møller Ly Lykke 
Published: November 2024

PurposePlay and exercise at the workplace have been promoted as ways to counter the development of lacking physical activity and improve workplace health. Through a reappraisal of the critical literature on workplace exercise, the analysis seeks to answer two questions: How do managers perceive employee health in the intersection between individual responsibility and collective community? How can the performative potentials of workplace exercise be critically understood?Design/methodology/approachWe use an institutional approach along with critical theories on management in which we argue that specific logics guide certain practices, values and beliefs within organizations. This qualitative study relies on insights from three diverse Danish workplaces that have implemented exercise during workhours.FindingsAdopting exercise and play as elements inspired by community sports becomes a powerful managerial technique. Managers combine practices such as play and voluntarism with the logics of profession and corporation. This gives rise to practices known from community sport that can lead to micro-emancipations during work as well as to subtle forms of managerial power by hiding explicit references to employee health.Originality/valueBy combining an institutional logics perspective with critical views, the study contributes to the growing body of research on workplace exercise by pointing to the potentials and constraints of adopting a community logic into practices. The study adds nuances to the view on workplace exercise in the critical management literature as well as illustrating the conditions necessary to make exercise and health promotion reconcilable with existing managerial practices.