bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telephone health survey estimates: Effects of nonresponse and sample limitations
Authors: Fowler Floyd J. , Brenner Philip S. , Buskirk Trent D. , Roman Anthony 
Published: January 2019

ObjectiveThe objective of this study was to assess nonresponse error in telephone health survey data based on an address‐based sample.Data SourcesTelephone and in‐person interviews in Greater Boston.Study Design/Data CollectionInterviewers attempted telephone interviews at addresses that were matched to telephone numbers using questions drawn from federal health surveys. In‐person household interviews were carried out with telephone nonrespondents and at addresses without matching telephone numbers.Principal FindingsAfter adjusting for demographic differences, only eight of 15 estimates based on the telephone interviews lay within two standard errors of the estimates when data from all three groups were included.ConclusionsFor health surveys of address‐based samples, many estimates based on telephone respondents differ from the total population in ways that cannot be corrected with simple demographic adjustments.
Vision‐related quality of life according to location of visual field loss in patients with glaucoma
Authors: Chun Yeoun Sook , Sung Kyung Rim , Park Chan Kee , Kim Hwang Ki , Yoo Chungkwon , Kim Yong Yeon , Park Ki Ho , Kim Chan Yun , Choi Kyu‐Ryong , Lee Kyoo Won , Han Seungbong , Kim Chang‐sik ,   the LIGHT (Life Quality of Glaucoma Patients Who Underwent Treatment) study of the Korean Glaucoma Society
Published: January 2019

AbstractPurposeTo assess influence of the location of visual field (VF) loss on vision‐related quality of life (VRQOL) in patients with glaucoma.MethodsWe included 826 patients with primary open‐angle glaucoma (POAG) enrolled in the prospectively designed Life Quality of Glaucoma Patients Who Underwent Treatment (LIGHT) study organized by the Korean Glaucoma Society. We divided the integrated binocular visual field (IVF) into four regions and evaluated the associations between Rasch‐analysed 25‐item National Eye Institute Visual Function Questionnaire (NEI VFQ‐25) and location of the IVF using univariate and hierarchical multivariable linear regression.ResultsMean deviation (MD) of the IVF at superior centre showed the lowest value among the four regions. Multivariable linear regression analysis revealed significant correlation of the composite score and all subscales of the NEI VFQ‐25 except ocular pain and near activities at each of four IVF regions. Mean deviation at superior centre showed significant correlation with composite score (R2 = 0.181), near activities (R2 = 0.175), and social functioning (R2 = 0.166); MD at superior periphery showed highest correlation with role difficulties (R2 = 0.137); MD at inferior centre showed highest correlation with driving (R2 = 0.145); and MD at inferior periphery showed significant correlation with distance activities (R2 = 0.214) and dependency (R2 = 0.119).ConclusionFour different regions of the IVF had a similarly important impact on subscales of the NEI VFQ‐25 in glaucoma patients. Preservation of the superior field should be considered as much as that of the inferior field for maintaining a good VRQOL in patients with glaucoma.
No conscientious objection without normative justification: A reply
Authors: Blackshaw Bruce P. 
Published: January 2019

AbstractBenjamin Zolf, in his recent paper ‘No conscientious objection without normative justification: Against conscientious objection in medicine’, attempts to establish that in order to rule out arbitrary conscientious objections, a reasonability constraint is necessary. This, he contends, requires normative justification, and the subjective beliefs that ground conscientious objections cannot easily be judged by normative criteria. Zolf shows that the alternative of using extrinsic criteria, such as requiring that unjustified harm must not be caused, are likewise grounded on normative criteria. He concludes that conscientious objection is therefore untenable. Here, I present an alternative account, based on the value we are willing to place on conscientious objection as an expression of freedom of conscience and religion. Using an extrinsic criterion such as harm, we can make a judgement of what degree of harm should be tolerated as the cost of permitting conscientious objection. A normative criterion for judging individual claims is therefore not required.
Testing the Heckscher–Ohlin–Vanek theory with a natural experiment
Authors: Zimring Assaf 
Published: January 2019

AbstractI use the historical episode of near‐elimination of commuting from the West Bank into Israel to test three key predictions of the Heckscher–Ohlin–Vanek model of trade and find strong support for them. On the production side, I use variation between districts and find that wage changes were not correlated with the size of the shock to the labour force (factor price insensitivity) and that districts that received larger influx of returning commuters shifted production more towards labour‐intensive industries (Rybczynski effect). On the consumption side, data are consistent with identical homothetic preferences, which, combined with the production results, supports the Heckscher–Ohlin–Vanek theorem on the factor content of trade.
Identification and characterization of a naïve CD8+ T cell repertoire for benzylpenicillin
Authors: Bechara Rami , Maillere Bernard , Joseph Delphine , Weaver Richard J. , Pallardy Marc 
Published: January 2019

SummaryBackgroundBeta‐lactams allergy is the most commonly reported drug allergy and constitutes an important health problem. We previously showed the pre‐existence of a naïve CD4+ T cell repertoire for benzylpenicillin (BP) coupled to human serum albumin (HSA) but little is known about the naïve CD8+ T cell repertoire specific for BP.ObjectiveThe purpose of this work was to identify naïve CD8+ T cells specific for BP and to explore mechanisms dictating their activation.MethodsCo‐cultures were established with naïve CD8+ T cells and autologous dendritic cells (DCs) loaded with HSA‐BP or free BP. T cells were restimulated once a week with autologous DCs loaded with HSA‐BP or BP. The specific CD8+ T cell response was measured using an IFN‐γ ELISpot assay.ResultsWhen using free BP, we were able to detect a naïve CD8+ T cell repertoire for BP in the 6 out of 7 tested healthy donors. However, our results showed that HSA‐BP was recognized by naïve CD8+ T cells in only one donor out of five tested healthy donors. Using free BP, we evidenced its binding to cellular proteins in DCs that was concentration dependent and was correlated with BP‐specific CD8+ T cell activation. Moreover, the BP‐specific CD8+ cell response was MHC class I‐dependent and required intracellular processing and proteasome activity.Conclusion and clinical relevanceThis work showed the existence of a naïve CD8+ T cell repertoire for BP when DCs were treated with free BP suggesting that patients could be immunized by haptenated peptides from cellular proteins generated in antigen‐presenting cells.
Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Authors: Mojtahed Poor S , Ulshöfer T , Gabriel L A , Henke M , Köhm M , Behrens F , Geisslinger G , Parnham M J , Burkhardt H , Schiffmann S 
Published: January 2019

Summary
Introduction of biotherapeutics has been a major milestone in the treatment of different chronic diseases. Nevertheless, the immune system can recognize the administered biological as non-self and respond with generation of anti-drug antibodies (ADA), including neutralizing ADA (nADA). Immunogenic responses may result in altered drug dynamics and kinetics leading to changes in safety and efficacy. However, there are several challenges with standard techniques for immunogenicity testing. Ustekinumab (UST), used in different inflammatory diseases, is a therapeutic antibody directed against the shared p40 subunit of interleukin (IL)-12 and IL-23, interfering in the pathogenically crucial T helper type 1 (Th1)/Th17 pathway. We established and validated different approaches for detection and quantitation of UST, UST-specific ADA and nADA. Addressing the obstacle of complex formation of UST with nADA, we developed an acidification assay to approach the total amount of nADA. Validated methods were based on surface plasmon resonance spectroscopy (SPR), enzyme-linked immunosorbent assay (ELISA) and a cell-based approach to characterize neutralizing capacity of nADA. Parameters assessed were determination and quantitation limits, linearity, range, precision, accuracy and selectivity. Quantitation of ADA and UST was feasible at lower concentrations using ELISA, whereas SPR showed a wider linear range for determination of ADA and UST. Accuracy, precision and linearity for quantitation were comparable using ELISA, SPR and the cell-based approach. All validated parameters fulfill the requirements of regulatory agencies. A combination of the testing approaches could address the increasing demand of precision medicine as it can be suitable for capturing the whole spectrum of immunogenicity and is transferable to other biologicals.
Clinical outcomes and cortical reserve in adrenal histoplasmosis—A retrospective follow‐up study of 40 patients
Authors: Singh Mahaveer , Chandy David D. , Bharani Tamnay , Marak Rungmei S. K. , Yadav Subhash , Dabadghao Preeti , Gupta Sushil , Sahoo Saroj K. , Pandey Rakesh , Bhatia Eesh 
Published: January 2019

SummaryObjectiveDetailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy.DesignSingle‐centre retrospective hospital‐based study of 40 consecutive adults with AH [39 males; age (mean ± SD) 53 ± 11 years] was conducted between 2006 and 2018. The median duration of follow‐up was 2.5 years (range 0.2‐12 years).Patients and methodsAH was diagnosed by bilateral adrenal enlargement on CT scan and presence of Histoplasma by histology and/or culture of biopsied adrenal tissue. All patients received oral itraconazole and, if required, amphotericin B as per guidelines. ACTH‐stimulated serum cortisol (normal > 500 nmol/L) was measured in 38 patients at diagnosis and re‐tested after one year of antifungal therapy in 21 patients.ResultsSeventy‐three per cent of patients had primary adrenal insufficiency (PAI) and one‐third had an adrenal crisis at presentation. HIV antibody was negative in all patients. Of the 29 patients who completed antifungal therapy, 25 (86%) were in remission at last follow‐up. Overall, 8 (20%) patients died: three had a sudden death, four had severe histoplasmosis and one died due to adrenal crisis. No patient with PAI became eucortisolemic on re‐testing after one year of antifungal therapy. Of the eight patients with normal cortisol at diagnosis, two developed adrenal insufficiency on follow‐up.ConclusionAll patients with AH tested negative for HIV antibody. While patients achieved a high rate of clinical remission after antifungal therapy, overall mortality was significant. Cortisol insufficiency did not normalize despite treatment.
QingBai decoction regulates intestinal permeability of dextran sulphate sodium‐induced colitis through the modulation of notch and NF‐κB signalling
Authors: Lin Jun‐Chao , Wu Jie‐Qiong , Wang Fang , Tang Feng‐Ying , Sun Jia , Xu Bing , Jiang Mingzuo , Chu Yi , Chen Di , Li Xiaowei , Su Song , Zhang Yujie , Wu Nan , Yang Shaoqi , Wu Kaichun , Liang Jie 
Published: January 2019

AbstractObjectiveChinese Herb QingBai decoction (QBD) has been approved affective in the treatment of IBD patients in clinic. However, the underlying mechanism remains unknown. We aim to investigate the effect of QBD on the mouse model of ulcerative colitis and its possible mechanism.MethodsC57/bL mice were given 5% DSS to induce colitis and were divided as QBD and mesalazine group. Weight, faeces and mental status were recorded each day and the histopathological changes (goblet cells etc) of the colon were observed after sacrificed. Fluorescein isothiocyanate‐dextran 4000 was measured to reflect the intestinal mucosal permeability. In addition, cell junction‐related proteins and possible signal pathways were investigated.ResultsQingBai decoction could significantly alleviate the inflammation and the protection effect of colitis is comparable as those in mesalazine enema group. It was found that the permeability reduced significantly with QBD treatment vs the control group, while no significant difference between the mesalazine and QBD groups. QBD treatment could upregulate the expression of tight junction complex（ZO‐1, claudin‐1 and occludin）and muc‐2 expression. It significantly reduced the production and secretion of serials proinflammatory cytokines (IL‐1β, IL‐6, Kc and TNF‐α) compared with the control group. Meanwhile, NF‐κB and Notch pathways were regulated.ConclusionQingBai decoction can effectively alleviate intestinal inflammation and mucosal barrier function in colitis mice, and the mechanism may be related to the inhibition of inflammatory cascade as well as enhanced mucus layer barrier and mechanical barrier function by NF‐κB and Notch signalling.
Access to Routinely Collected Clinical Data for Research: A Process Implemented at an Academic Medical Center
Authors: Guerrero Susan C. , Sridhar Sujatha , Edmonds Cynthia , Solis Christina F. , Zhang Jiajie , McPherson David D. , Bernstam Elmer V. 
Published: January 2019

Electronic health records are valuable for clinical and translational research. Institutions must protect patient privacy and comply with applicable regulations while allowing appropriate access to clinical data for research. The processes that investigators must follow to access clinical data can be substantially different at different institutions. In this paper, we describe the process developed at our institution that has been active for 5 years and was used to satisfy over 200 requests for access to identified clinical data, usually within 1 day for internal requests and 3 days for visiting researchers.
RANKL is associated with persistent primary teeth and delayed permanent tooth emergence
Authors: Arid Juliana , Xavier Thaís Aparecida , da Silva Raquel Assed Bezerra , De Rossi Andiara , da Silva Lea Assed Bezerra , de Queiroz Alexandra Mussolino , Galo Rodrigo , Antunes Lívia Azeredo Alves , Silva Marcelo José Barbosa , Antunes Leonardo Santos , Abbasoglu Zerrin , Nelson Filho Paulo , Küchler Erika Calvano , Fukada Sandra Yasuyo 
Published: January 2019

BackgroundTooth eruption is a process that is not fully understood.AimTo evaluate whether genetic polymorphisms for RANK/RANKL/OPG are associated with delayed tooth emergence. To evaluate whether the relative expression of this genes is associated with persistent primary teeth.DesignTo evaluate whether genetic polymorphisms for RANK/RANKL/OPG could be involved in delayed tooth emergence, saliva samples from 160 children, aged 6‐13 years old, were analysed. To test if there is correlation between gene expression of RANK/RANKL/OPG in children with delayed tooth emergence and persistent primary teeth, periapical tissue from 15 children with persistent primary teeth and from 15 control subjects were collected for qPCR analysis.ResultsFifty‐six children with delayed tooth emergence (35%) had at least one permanent tooth with delayed emergence. The T allele in RANKL (rs9594738) increased the risk of delayed tooth emergence (P = 0.02; OR = 1.71, 95%CI 1.09‐2.75). The relative gene expression for RANKL and the ratio RANKL/OPG in children with delayed tooth emergence and persistent primary teeth were lower compared to controls (P = 0.02 and P = 0.005, respectively).ConclusionsData suggest that the polymorphism rs9594738 in RANKL is associated with delayed permanent tooth emergence. Moreover, reduced relative gene expression of RANKL in periapical tissue is associated with persistent primary teeth.
High triglyceride to high‐density lipoprotein cholesterol ratio and arterial stiffness in postmenopausal Korean women
Authors: Chung Tae‐Ha , Shim Jae‐Yong , Kwon Yu‐Jin , Lee Yong‐Jae 
Published: January 2019

The ratio of triglyceride to high‐density lipoprotein cholesterol (TG/HDL) is positively linked to insulin resistance, and it has emerged as an independent predictor of cardiovascular disease. Menopause is characterized by various detrimental metabolic and vascular changes that may lead to high TG with low HDL cholesterol and arterial stiffness. Several epidemiological studies have reported that high TG/HDL ratio has a positive association with arterial stiffness in both adult and adolescent populations; it is not known whether TG/HDL ratio is related to brachial‐ankle PWV (baPWV) in postmenopausal women. Thus, the authors aimed to investigate the association between TG/HDL ratio and arterial stiffness as measured by baPWV in 434 postmenopausal women. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for high baPWV were calculated after adjusting for confounding variables across TG/HDL ratio quartiles using multiple logistic regression analysis. The mean values of meaningful cardiometabolic variables increased with TG/HDL ratio quartiles. The adjusted baPWV (SEs) significantly increased with TG/HDL quartiles: Q1 = 1412 (22.1), Q2 = 1469 (21.4), Q3 = 1482 (21.0), and Q4 = 1505 (21.6) cm/s after adjusting for age, body mass index (BMI), and systolic blood pressure. The OR (95% CI) of the highest TG/HDL ratio quartile as compared to the lowest TG/HDL ratio quartile for high PWV was 2.77 (1.16‐6.63) after adjusting for age, BMI, smoking status, regular exercise, mean arterial pressure, fasting plasma glucose, total cholesterol level, hypertension, log‐transformed C‐reactive protein, and the use of antihypertensive and lipid‐lowering drugs. The TG/HDL ratio was positively and independently associated with arterial stiffness in postmenopausal Korean women.
‘Absent’ pulmonary valve with intact ventricular septum mimicking tricuspid valve atresia: Prenatal diagnosis and postnatal course
Authors: Monacci Francesca , Bondi Tommaso , Canessa Clementina , Chiappa Enrico 
Published: January 2019

AbstractAbsent pulmonary valve syndrome is a rare congenital heart disease characterized by absent or rudimentary pulmonary valve leaflets and hypoplastic pulmonary annulus. The most common variant, associated with tetralogy of Fallot, implies dilatation of pulmonary branches and usually absent ductus arteriosus. Rarely, absent pulmonary valve occurs with intact ventricular septum: pulmonary branches are normally sized or mildly dilated and ductus arteriosus is usually patent. The rarest type is associated with intact ventricular septum and tricuspid atresia. A close connection has been raised between pulmonary regurgitation and development of tricuspid valve. We describe a case of prenatal diagnosed absent pulmonary valve with intact ventricular septum and patent ductus arteriosus in which severe pulmonary regurgitation caused reversible functional atresia of tricuspid valve. Postnatally, satisfactory biventricular circulation was obtained with inotropic support for a few days while ductus arteriosus closed spontaneously. At a 3‐year follow up the child is asymptomatic without therapy.
Unusual facio‐upper arm band of a fetus mimicking amniotic band syndrome
Authors: Inan Cihan , Sayin N. Cenk , Gurkan Hakan , Erzincan Selen G. , Uzun Isil , Sutcu Havva , Atli Engin , Varol Fusun 
Published: January 2019

AbstractAmniotic band syndrome can lead to a wide spectrum of congenital abnormalities including orofacial and visceral defects. It is associated with malformations in truncal, craniofacial regions and the limbs, whereas it sometimes may imitate some genetic disorders. Here, we present an atypical case mimicking amniotic band syndrome with a facio‐upper arm band that was having multiple fetal structural abnormalities including scoliosis, bilateral cleft lip and palate, upper limb abnormality, unilateral anophthalmia with contralateral microphthalmia, left hypertrophic kidney and severe ventriculomegaly.
Memory studies and the eighteenth century
Authors: Davis Leith 
Published: January 2019

AbstractInMemory in Culture, Astrid Erll contends that if we want to understand the various crises of the present, we need to consider the “mental, discursive, and habitual paradigms that were formed in long historical processes – via cultural memory.” In the current climate of debates about the national past, it is timely to take stock of the field of memory studies, as such studies can help us understand, as Ann Rigney suggests, “how stories about the past emerge as common points of reference and, in the process, help to define collective identities.” This article will provide some background to the field of memory studies and discuss two important new directions in the field: a concern with the mediation of memory and an interest in postcolonial, transnational, and “traveling” memory. The specific objective is to consider the relevance of memory studies for scholars of 18th‐century literature and, conversely, the relevance of 18th‐century literature for the field of memory studies. The broader aim is to encourage further work that will focus attention on the constructedness of even the most long‐standing and pervasive national memories.
Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens
Authors: Rother Ulrich , Amann Kerstin , Adler Werner , Nawroth Nina , Karampinis Ioannis , Keese Michael , Manap Serhat , Regus Susanne , Meyer Alexander , Porubsky Stefan , Hilgers Karl , Krämer Bernhard K. , Lang Werner , Nowak Kai , Gerken Andreas L. H. 
Published: January 2019

AbstractObjectiveICG fluorescence angiography enables a quantitative real‐time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre‐transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference.MethodsSeventy‐seven patients with end‐stage renal disease undergoing kidney transplantation were prospectively included in two centers. Correlation analysis of chronic changes in kidney biopsy specimens and the IN ofICGfluorescence signal were investigated.ResultsThe results yielded a significantly negative correlation for the renal chronicity (r = −0.294,P = 0.017) as well as the intestinal fibrosis and tubular atrophy score (r = −0.328,P = 0.007). There was a significant inverse relationship between the IN and the meanRIvalues of the upper pole of the kidney allograft.ConclusionsIn summary, fluorescence angiography reflects preexisting morphological changes of the renal cortex.ICGangiography may serve as an alternative method for the assessment of microperfusion of the kidney allograft.