bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed‐time adaptive sliding mode trajectory tracking control of uncertain mechanical systems
Authors: Sun Liang , Liu Yuanji 
Published: April 2019

AbstractAn adaptive fixed‐time trajectory tracking controller is proposed for uncertain mechanical systems in this study. The polynomial reference trajectory is planned for trajectory tracking error. Fractional power of linear sliding mode is applied to design the nonlinear controller, adaptive laws are used to adjust controller parameters. Trajectory planning and fractional power are combined to ensure the tracking‐error convergence in a fixed time. The boundary layer technique is used to suppress the model uncertainties and decrease the chattering phenomenon. The closed‐loop system stability is proved strictly in the Lyapunov framework to show that the trajectory tracking errors and adaptive parameters tend to zero in a fixed time set in advance. Numerical simulation results of robotic manipulators illustrate the effectiveness of the proposed controller.
Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender
Authors: Sturm Alexandra , Kasari Connie 
Published: April 2019

There is a pressing need to better characterize the college‐bound population of individuals with autism spectrum disorder (ASD), as prior studies have included small samples, consisting of individuals who are either recruited due to diagnosis or are treatment seeking. As postsecondary institutions look to respond to the growing need for support services for individuals with ASD, insights derived from large, population‐based samples is a necessity. The current study included a sample of over 2000 incoming postsecondary students who self‐identified with ASD as a part of surveys distributed by institutions nationally. The impact of heterogeneity (gender, comorbid attention‐deficit/hyperactivity disorder [ADHD], and/or learning disability) on demographic characteristics, and psychosocial (psychological health, interpersonal self‐confidence) and academic (self‐regulated learning, intellectual self‐confidence) domains critical for success in postsecondary education were compared to a matched sample of students with ADHD or no diagnoses. College‐bound students with ASD broadly endorsed similar rates of ADHD, LD, and psychological disorder comorbidity to clinic‐referred samples, and were more similar than different from their typically developing peers. A comorbid diagnosis of ADHD was associated with greater academic disengagement. Females with ASD and those with any comorbid disorder were more likely to self‐report poorer psychological health. Findings revealed that self‐reported levels of functioning in critical domains differed by self‐reported comorbid disorders and gender. Findings have implications for targeted support service recommendations based on unique sources of heterogeneity (e.g., gender, presenting comorbid disorders) and are detailed in the current study. Autism Res 2019, 12: 931–940. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryCollege‐bound students with ASD feel academically competent; however feel less confident with their peers. Students with ASD and another diagnosis (e.g., ADHD, learning disability) and girls with ASD may be particularly at risk of experiencing poorer psychological health while enrolled in postsecondary education. Using this information, postsecondary institutions can provide more targeted support services to students with ASD enrolled in postsecondary education.
Rate it again: Using the wisdom of many to improve performance evaluations
Authors: Barneron Meir , Allalouf Avi , Yaniv Ilan 
Published: April 2019

AbstractMuch research shows that judgmental estimation could be improved by combining estimates from independent judges as well as within judges. These results have been obtained mostly with judgments about matters of fact, that is, for which there are objective truth criteria. In the present research, we extend these findings to performance evaluations. In a controlled field study, expert judges provided evaluations of a large number of essays written by college applicants taking college entrance tests. The judges were asked to evaluate each essay twice—on two occasions, a week apart. This design allowed us to assess the benefits of two methods of combining evaluations: within rater and across raters. Accuracy gains were obtained with both methods. Although the within‐rater combinations yielded fewer gains than the across‐rater ones, they were still appreciable in comparison with the across rater ones. Our findings extend the class of judgments to which the “wisdom of many” could be applied. These findings are potentially applicable to performance evaluations in social, educational, and employment settings.
How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?
Authors: van Niekerk Gustav , Davis Tanja , Patterton Hugh‐George , Engelbrecht Anna‐Mart 
Published: April 2019

Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and hyperglycemia. Second, emerging evidence indicates that a decrease in mitochondrial respiration and an increase in reactive oxygen species (ROS) production are not necessarily manifestations of pathology, but adaptations taking shape as the mitochondria is abdicating its adenosine triphosphate (ATP)‐producing function (which is taken over by glycolysis) and instead becomes “retooled” for an immunological role. Collectively, these observations challenge the commonly held belief that acute hyperglycemia induces mitochondrial damage leading to immune cell dysfunction.
Effects of phosphonium‐based ionic liquids on the lipase activity evaluated by experimental results and molecular docking
Authors: Barbosa Milson S. , Freire Cintia C. C. , Souza Ranyere L. , Cabrera‐Padilla Rebeca Y. , Pereira Matheus M. , Freire Mara G. , Lima Álvaro S. , Soares Cleide M. F. 
Published: April 2019

AbstractIn this work, the effect of several phosphonium‐based ionic liquids (ILs) on the activity of lipase fromBurkholderia cepacia(BCL) was evaluated by experimental assays and molecular docking. ILs comprising different cations ([P4444]+, [P444(14)]+, [P666(14)]+) and anions (Cl−, Br−, [Deca]−, [Phosp]−, [NTf2]−) were investigated to appraise the individual roles of IL ions on the BCL activity. From the activity assays, it was found that an increase in the cation alkyl chain length leads to a decrease on the BCL enzymatic activity. ILs with the anions [Phosp]−and [NTf2]−increase the BCL activity, while the remaining [P666(14)]‐based ILs with the Cl−, Br−, and [Deca]−anions display a negative effect on the BCL activity. The highest activity of BCL was identified with the IL [P666(14)][NTf2] (increase in the enzymatic activity of BCL by 61% at 0.055 mol·L−1). According to the interactions determined by molecular docking, IL cations preferentially interact with the Leu17 residue (amino acid present in the BCL oxyanion hole). The anion [Deca]−has a higher binding affinity compared to Cl−and Br−, and mainly interacts by hydrogen‐bonding with Ser87, an amino acid residue which constitutes the catalytic triad of BCL. The anions [Phosp]−and [NTf2]−have high binding energies (−6.2 and −5.6 kcal·mol−1, respectively) with BCL, and preferentially interact with the side chain amino acids of the enzyme and not with residues of the active site. Furthermore, FTIR analysis of the protein secondary structure show that ILs that lead to a decrease on the α‐helix content result in a higher BCL activity, which may be derived from an easier access of the substrate to the BCL active site.
Comparing high‐dose cisplatin with cisplatin‐based combination chemotherapy in definitive concurrent chemoradiation setting for locally advanced head and neck squamous cell carcinoma (LAHNSCC)
Authors: Furqan Muhammad , Snyders Travis P. , Saqlain Mohammed U. , Mott Sarah L. , Laux Douglas , Snow Anthony , Anderson Carryn M. , Watkins John M. , Clamon Gerald H. 
Published: April 2019

AbstractBackgroundHigh‐dose cisplatin (Cis) is a preferred systemic agent for concurrent chemoradiation (CRT) in locally advanced head and neck squamous cell cancer (LAHNSCC) patients. As some patients are unable to tolerate Cis, this study compares the toxicity and efficacy of weekly cisplatin‐paclitaxel (CP) regimen with Cis.MethodsPatients with LAHNSCC receiving definitive chemoradiation either with Cis (Cisplatin—100 mg/m2 q3w x 3) or CP (Cisplatin—20 mg/m2; Paclitaxel—30 mg/m2qw x7) were included.ResultsCis and CP groups were comprised of 114 and 111 subjects, respectively. Complete response for Cis versus CP groups was 88% versus 88%, respectively. Median follow‐up for the study was 58.5 months. After adjusting for potential treatment selection bias, no significant differences were evident between Cis and CP groups for overall survival (hazard ratios [HR] 0.85, 95% CI 0.59‐1.21, P = 0.36), progression free survival (HR 0.88, 95% CI 0.62‐1.24, P = 0.46), locoregional control (HR 0.77, 95% CI 0.52‐1.15, P = 0.21), and distant control (HR 0.87, 95% CI 0.61‐1.23, P = 0.42). Patients in the CP group had less acute and chronic toxicities.ConclusionsWeekly CP regimen can serve as an alternative systemic therapy with radiation in patients with LAHNSCC who are not fit for Cis.
Gene amplification derived a cancer‐testis long noncoding RNA PCAT6 regulates cell proliferation and migration in hepatocellular carcinoma
Authors: Chen Shuaizhou , Chen Yao , Qian Qufei , Wang Xuewei , Chang Yuting , Ju Sihan , Xu Yide , Zhang Chang , Qin Na , Ding Hui , Gu Yayun , Han Jing , Wang Cheng , Zhang Erbao , Hu Zhibin 
Published: April 2019

AbstractOur previous work demonstrated cancer‐testis (CT) genes as a new source of candidate driver of cancer. Recently, mounting evidence indicates that long noncoding RNAs (lncRNAs) with CT expression pattern could play a pivotal role in cancer biology. Here, we characterized a conserved CT long noncoding RNA (CT‐lncRNA), PCAT6, which is expressed exclusively in the testis and is reactivated in liver hepatocellular carcinoma (LIHC) tissues due to the highly frequent amplification. The expression in LIHC was correlated with clinical prognosis in TCGA data. Knockdown of PCAT6 could inhibit cell proliferation and migration in hepatocellular carcinoma (LIHC) cells. Gene set enrichment analysis (GSEA) based on coexpression network revealed that PCAT6 was involved in similar cilium‐related pathways in the testis and LIHC tissues. However, PCAT6 was mainly positively correlated with gametogenesis‐related pathways in the testis but was coexpressed with mitotic cell cycle genes in LIHC. Together, our data demonstrated that CT‐lncRNA PCAT6 represents the similarity and difference between tumorigenesis and gametogenesis. The CT expression pattern and important role in LIHC oncogenesis make PCAT6 an ideal target for LIHC diagnosis and therapy.
Self‐concept of relational skills in psychotherapy trainees: A pilot study
Authors: Tilkidzhieva Elitsa , Gelo Omar C. G. , Gullo Salvatore , Orlinsky David E. , Mörtl Kathrin , Fiegl Jutta 
Published: April 2019

AbstractBackgroundPersonal characteristics and relational skills represent central aspects of the psychotherapist's work, and yet, little is still known about them in the context of psychotherapy training.ObjectiveThis paper presents a preliminary exploration of the self‐concepts of relational skills in psychotherapy trainees. Changes in the self‐concept in N = 131 psychotherapy trainees were explored through analysis of self‐image ideal‐self and self/ideal‐self discrepancy in two stages (beginning vs. advanced).MethodData were collected with a modified version of the self‐rated instruments Trainee Background Information Form and Trainee Current Practice Report (Orlinsky et al., 2015), and analysed with analyses of covariances for each dependent variable.ResultsExpected differences in the self‐image of beginning versus advanced trainees were not detected. However, differences in trainees’ ideal‐self and in self/ideal‐self discrepancy were found. Some gender and age differences were also detected.ConclusionsThe results suggest possible changes in the self‐concept of relational skills, indicative of self‐development processes such as discovering a realistic sense of self and self‐boundaries, managing intensive emotional interactions and developing regulatory interpersonal mechanisms. An in‐depth and more refined future exploration of various aspects of the self‐concept in the context of psychotherapy training is needed to help understand the complex processes of forming an integrated self of psychotherapists.
Clinical outcomes at 2 years of the Absorb bioresorbable vascular scaffold versus the Xience drug‐eluting metallic stent in patients presenting with acute coronary syndrome versus stable coronary disease—AIDA trial substudy
Authors: Tijssen Ruben Y.G. , van der Schaaf Rene J. , Kraak Robin P. , Vink Maarten A. , Hofma Sjoerd H. , Arkenbout E. Karin , Weevers Auke P.J.D. , Kerkmeijer Laura S.M. , Onuma Yoshinobu , Serruys Patrick W. , Beijk Marcel A.M. , Koch Karel T. , Baan Jan , Vis M. Marije , Piek Jan J. , Tijssen Jan G.P. , Henriques Jose P.S. , de Winter Robbert J. , Wykrzykowska Joanna J. 
Published: April 2019

AbstractBackgroundPatients with acute coronary syndrome (ACS) might represent a specific subgroup, in which bioresorbable scaffold implantation in percutaneous coronary intervention (PCI), might lead to better outcomes when compared to conventional treatment with metallic drug eluting stents. In this prespecified subgroup analysis of the Amsterdam Investigator‐Initiated Absorb Strategy All‐Comers (AIDA) trial, we evaluated the clinical outcomes of Absorb bioresorbable vascular scaffold (BVS) versus Xience everolimus eluting stent (EES) treated patients presenting either with or without ACS.Methods and resultsWe classified AIDA patients on the basis of clinical presentation of ACS or of no‐ACS. The rate of the 2‐year primary endpoint of target vessel failure (TVF) was similar after treatment with Absorb BVS or Xience EES in ACS patients (10.2% versus 9.0% respectively; P = 0.49) and in no‐ACS patients (11.7% versus 10.7%, respectively; P = 0.67) Definite or probable device thrombosis occurred more frequently with Absorb BVS compared to Xience EES in ACS patients (4.3% versus 1.7%, respectively, P = 0.03) as well as in no‐ACS patients (2.4% versus 0.2%, respectively; P = 0.002). There were no statistically significant interactions between clinical presentation and randomized device modality for TVF (P = 0.80) and for the endpoint of definite or probable device thrombosis (P = 0.17).ConclusionIn the AIDA trial, the 2‐year outcomes of PCI with Absorb BVS versus Xience EES were consistent in ACS and no‐ACS patients: similar rates for TVF and consistently higher rates of definite or probable stent thrombosis under Absorb BVS versus Xience EES. There were no statistically significant interactions between clinical presentation and randomized device modality.
Use of wearable cardioverter‐defibrillator in association with catheter ablation for atrial fibrillation‐related tachycardiomyopathy
Authors: Conti Sergio , Bonomo Vito , Taormina Antonio , Giordano Umberto , Sgarito Giuseppe 
Published: April 2019

Key Clinical MessageImplantable cardioverter‐defibrillator (ICD) is an effective therapy in patients known to be at high risk for sudden cardiac death (SCD). Nevertheless, ICD implantation is not indicated in transient or reversible causes of SCD. Wearable cardioverter‐defibrillator is increasingly used for SCD prevention in patients with a transient risk of ventricular arrhythmia.
Phosphine Ligand‐Free Ruthenium Complexes as Efficient Catalysts for the Synthesis of Quinolines and Pyridines by Acceptorless Dehydrogenative Coupling Reactions
Authors: Guo Bin , Yu Tian‐Qi , Li Hong‐Xi , Zhang Shi‐Qi , Braunstein Pierre , Young David J. , Li Hai‐Yan , Lang Jian‐Ping 
Published: April 2019

AbstractA series of phosphine‐free Ru(III)/Ru(II) complexes of NH functionalized N˄N˄N pincer ligands exhibit excellent activity for acceptorless dehydrogenative coupling (ADC) of secondary alcohols with 2‐aminobenzyl or γ‐amino alcohols to quinolines and pyridines. Ru(III) complexes [LRuCl3] (L=6‐(3‐R1,5‐R2‐1H‐pyrazol‐1‐yl)‐N‐(pyridin‐2‐yl)pyridin‐2‐amine; 1 a: R1=R2=H (L1); 1 b: R1=R2=Me (L2); 1 c: R1=H, R2=CF3 (L3); 1 d: R1=H, R2=Ph (L4); 1bMe: L=6‐(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐N‐methyl‐N‐(pyridin‐2‐yl)pyridin‐2‐amine (L2Me)) were obtained by refluxing RuCl3 ⋅ xH2O with the corresponding ligand in EtOH. Five Ru(II) complexes [LRu(DMSO‐κS)Cl2] (2 a: L=L1; 2 b: L=L2; 2 c: L=L3; 2 d: L=L4; 2bMe: L=L2Me) were formed by reducing the corresponding Ru(III) complex in refluxing EtOH. The latter complexes could also be prepared directly by refluxing Ru(DMSO)4Cl2 with the corresponding ligand in EtOH. These Ru(III) and Ru(II) complexes, especially 1 b/2 b, exhibited high catalytic efficiency and broad functional group tolerance in ADC reactions of secondary alcohols with 2‐aminobenzyl or γ‐amino alcohols to quinolines and pyridines. A detail mechanistic study indicated the Ru(III) complex was reduced into the Ru(II) species, which is the active catalytic center for ADC via a Ru−H/N−H bifunctional outer‐sphere mechanism. This protocol provides a reliable, atom‐economical and environmentally benign procedure for C−N and C−C bond formation.
Binder‐Free Electrodes Derived from Interlayer‐Expanded MoS2 Nanosheets on Carbon Cloth with a 3D Porous Structure for Lithium Storage
Authors: Han Yan , Chatti Manjunath , Ge Yu , Wang Caiyun , Chao Yunfeng , Simonov Alexandr N. , Wallace Gordon G. 
Published: April 2019

AbstractAnchoring nanostructured MoS2 on a conductive carbon substrate is an effective approach to produce flexible binder‐free electrodes for energy storage applications. However, they are commonly fabricated through time‐consuming hydrothermal reactions. Herein, MoS2 nanosheet arrays grown on a flexible carbon fiber cloth (CC) have been synthesized within 2 h by using a microwave‐assisted method. These vertically aligned MoS2 nanosheets with expanded interlayer spacing of approximately 1 nm densely cover the support surface and form an interconnected network with significant void space. When employed as anodes for lithium‐ion batteries, the microwave‐synthesized binder‐free MoS2/CC composites exhibit a high areal capacity of 2.5 mAh cm−2 at 0.15 mA cm−2, excellent cycle performance, and good rate capability.
Electrochemical Characteristics of Cobaltosic Oxide in Organic Electrolyte According to Bode Plots: Double‐Layer Capacitance and Pseudocapacitance
Authors: Xu Yinsheng , Wang Shengping , Peng Huiling , Yang Zhigao , Martin Darren J. , Bund Andreas , Nanjundan Ashok Kumar , Yamauchi Yusuke 
Published: April 2019

AbstractPseudocapacitive behavior is usually observed in transition‐metal oxide anodes for lithium‐ion batteries, such as Co3O4. It is necessary to develop electrochemical technologies for clarifying the properties of the pseudocapacitance in the electrode reactions, as the understanding and controllable application of pseudocapacitance benefits the development of electrode materials with multi‐storage mechanisms for lithium‐ion batteries. To this end, in this work, electrode processes are divided into four component parts with corresponding equivalent circuit diagrams used to emphasize the pseudocapacitive behavior of Co3O4. After analyzing the properties of Bode plots in the whole frequency range (10−2–105 Hz), phase‐angle Bode plots are demonstrated to be suitable for revealing the pseudocapacitance for Co3O4 at a certain state. In addition,
is utilized to determine the magnitude of the pseudocapacitance and double‐layer capacitance. For Co3O4 in the fully charged state (3 V vs. Li+/Li), the pseudocapacitance and double‐layer capacitance are approximately 180.28 and 1.32 μF cm−2, respectively. Therefore, the goal of monitoring pseudocapacitive behavior for a transition‐metal oxide anode such as Co3O4 in a certain state without the influence of double‐layer capacitance and faradaic processes controlled by solid‐phase diffusion is realized by using Bode plots, greatly promoting the understanding and controllable application of pseudocapacitance.
S‐nitrosylation of cytoskeletal proteins
Authors: Horenberg Allison L. , Houghton Alisa M. , Pandey Saurav , Seshadri Vikram , Guilford William H. 
Published: April 2019

AbstractNitric oxide has pronounced effects on cellular functions normally associated with the cytoskeleton, including cell motility, shape, contraction, and mitosis. Protein S‐nitrosylation, the covalent addition of a NO group to a cysteine sulfur, is a signaling pathway for nitric oxide that acts in parallel to cyclic guanosine monophosphate (cGMP), but is poorly studied compared to the latter. There is growing evidence that S‐nitrosylation of cytoskeletal proteins selectively alters their function. We review that evidence, and find that S‐nitrosylation of cytoskeletal targets has complementary but distinct effects to cyclic‐GMP in motile and contractile cells—promoting cell migration, and biasing muscle contraction toward relaxation. However, the effects of S‐nitrosylation on a host of cytoskeletal proteins and functions remains to be explored.
Highly Efficient Dynamic Degradation of Methylene Blue on Hierarchical Nitrogen/Cobalt‐Co‐Doped Carbonaceous Beads with Diffusion Promoting Nanostructures
Authors: Zhao Xin , An Qing‐Da , Bo Shu‐Feng , Guo Dong‐Mei , Xiao Zuo‐Yi , Zhai Shang‐Ru , Li Zhong‐Cheng 
Published: April 2019

AbstractUn‐restricted diffusion channels for ions and molecules within catalytic composites is of practical significance for environmental remediation with aqueous reaction systems. Herein, hierarchical Co/N‐co‐doped carbonaceous beads with diffusion‐promoting nanostructures for activating peroxymonosulfate (PMS) were prepared through a seaweed‐based hydrogel strategy. Several technologies were applied to characterize resultant samples including XRD, SEM, TEM, XPS and N2 adsorption‐desorption. The degradation was carefully tested in simulations of real conditions such as in running water, laboratory waste liquid, and seawater, which indicated that the catalyst/PMS system has a practical and a wide range of degradation capacity. Moreover, SA/N−CoxOy could also prepared with waste cobalt solution, and also showed relatively good catalytic performance. In contrast to other works which mostly concentrated on the study of static testing, this research is mainly concerned with dynamic degradation. Batch and fixed‐bed column degradation experiments were simultaneously carried out to evaluate the efficiency and potential industrial applications, which revealed that the as‐prepared sample led to the fast removal of 90.26% of MB within 400 minutes and continuously degraded the dye for 25 h at 298 K. The recycling performance was also investigated by means of dynamic degradation tests, which only showed a slight decline with time.