bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of different salts on the gelation behaviour and mechanical properties of citric acid‐induced tofu
Authors: Zhao Yan‐Yan , Cao Feng‐Hong , Li Xing‐Jiang , Mu Dong‐Dong , Zhong Xi‐Yang , Jiang Shao‐Tong , Zheng Zhi , Luo Shui‐Zhong 
Published: August 2019

SummaryTo elucidate the effects of salts on the properties of citric acid‐induced tofu gel, gelation was induced in the presence of KCl, CaCl2 or CaSO4, and gypsum tofu was used as a reference. The textural properties, water‐holding capacity (WHC), rheological behaviour, aggregate size distribution and microstructure of the tofu were evaluated. The results indicated that the addition of 0.10 g/100 mL KCl,0.05 g/100 mL CaCl2 and 0.15 g/100 mL CaSO4 yields more elastic tofu with high water‐holding capacity. The WHC of tofu induced in the presence of salts was similar to that of gypsum tofu, while the tofu was firmer and less elastic than gypsum tofu. The maximum elasticity of citric acid‐induced tofu was obtained with addition of 0.15 g/100 mL CaSO4. These results are useful to understand the effects of different salts on soymilk gelation and provide a theoretical base for the quality improvement of citric acid‐induced tofu.
Real‐time PCR based on single‐copy housekeeping genes for quantitative detection of goat meat adulteration with pork
Authors: Wang Zhicheng , Wang Zhiying , Li Tingting , Qiao Lu , Liu Rui , Zhao Yan , Xu Zhenzhen , Chen Gang , Yang Shuming , Chen Ailiang 
Published: August 2019

SummaryAdulteration of goat meat with cheaper meat such as pork has been frequently found. Conventional PCR methods to distinguish goat meat from adulteration are qualitative, which easily produce false‐positive results due to contamination but not adulteration. To address this problem, real‐time PCR based on single‐copy housekeeping genes encoding replication protein A1 was developed for goat meat and pork. By calculating the Ct ratio of goat meat/pork, the goat meat content in a suspected adulteration could be deduced by a good linear correlation (R2 = 0.9868) in a range from 5% to 80%. Analysis of the simulated samples of goat meat showed high accuracy with recoveries of 104.91% and 105.00% for the goat meat contents of 40% and 60%, respectively, and coefficient of variations were as low as 9.24% and 9.09%. Thus, the developed assay supplied a useful tool for food regulation authorities to achieve quantitative authentication of goat meat.
Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China
Authors: Li Jiming , Zhang Huifen , Huang Xiaoli , Zhang Jiyong , Wu Xingdong 
Published: August 2019

AbstractObjectivesTo observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs).MethodsOverall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline.ResultsThe RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups.ConclusionsThere are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.
Specific stressors relate to nurses' job satisfaction, perceived quality of care, and turnover intention
Authors: Bautista John Robert , Lauria Percy Aiggie S. , Contreras Maria Cecilia S. , Maranion Maheni Micarla G. , Villanueva Hermeliza H. , Sumaguingsing Robert C. , Abeleda Ronne D. 
Published: August 2019

AbstractAimsTo determine which stressor has the highest occurrence and what stressors are related to nurse outcomes, such as job satisfaction, perceived quality of care, and turnover intention.BackgroundNumerous stressors have been identified in nursing practice, but it is unclear if specific stressors are related to nurse outcomes.DesignThe study used a cross‐sectional and descriptive‐correlational research design.MethodsIn July and August 2017, survey data were collected from 427 staff nurses employed in a large tertiary‐level private hospital in Metro Manila, Philippines. The Nursing Stress Scale was used to measure stress frequency. Structural equation modelling was used to determine the relationship of stressors and nurse outcomes.ResultsExploratory and confirmatory factor analyses indicate nine Nursing Stress Scale factors. Workload is the most frequent stressor. Moreover, workload was negatively related to job satisfaction and perceived quality of care. Workload and conflict with nurses were positively related to turnover intention.ConclusionsThe Nursing Stress Scale has a different factor structure based on a survey of nurses in the Philippines. Only workload and conflict with nurses were related to specific nurse outcomes. Nurse managers should identify and mitigate stressors experienced by nurses since these can lead to turnover and poor quality of care.
Laboratory‐derived early warning score for the prediction of in‐hospital mortality, intensive care unit admission, medical emergency team activation and cardiac arrest in general medical wards
Authors: Ratnayake Hasanka , Johnson Douglas , Martensson Johan , Lam Que , Bellomo Rinaldo 
Published: August 2019

AbstractBackgroundGeneral medical wards admit a varied cohort of patients from the emergency department, some of whom deteriorate during their hospital stay. Currently, we use vital signs based warning scores to predict patients at risk of imminent deterioration, but there is now a growing body of literature that commonly available laboratory results may also help to identify those at risk.AimTo assess whether a laboratory‐based admission score can predict in hospital mortality, intensive care unit (ICU) admission, medical emergency team (MET) activation or cardiac arrest in a cohort of Australian general medical patients admitted through the emergency department (ED).MethodsWe performed a retrospective observational study of all general medical admissions to hospital through the ED in 2015. Admission pathology was used to calculate a risk score. In‐patient outcomes of death, ICU transfer, MET call activation or cardiac arrest were collected from hospital records.ResultsWe studied 2942 admissions derived from 2521 patients, with a median age of 81 years. There were 143 in‐patient deaths, 82 ICU admissions, 277 MET calls and 14 cardiac arrest calls. The laboratory‐based admission score had an area under the receiver operating characteristic curve (AUC‐ROC) of 0.76 (95% confidence interval (CI): 0.72–0.80) for inpatient death, an AUC‐ROC of 0.79 (95% CI: 0.66–0.93) for inpatient cardiac arrest, an AUC‐ROC of 0.64 (95% CI: 0.58–0.70) for ICU transfer and an AUC‐ROC of 0.59 (95% CI: 0.55–0.62) for MET call activation. When patients aged over 75 were analysed separately, the AUC‐ROC for prediction of in‐patient death was 0.74 (95% CI: 0.70–0.78) and increased to 0.86 (95% CI: 0.73–0.98) for the prediction of in‐patient cardiac arrest.ConclusionA simple laboratory‐derived score obtained at patient admission is a fair to good predictor of subsequent in‐patient death or cardiac arrest in general medical patients and in the older patient cohort. Prospective interventional studies are required to ascertain the clinical utility of this admission score.
BNT‐based ferroelectric ceramics: Electrical properties modification by Ta2O5 oxide addition
Authors: Han Jihui , Yin Jie , Wu Jiagang 
Published: August 2019

AbstractDue to their superior piezo‐responses (strain S > 0.3%), bismuth sodium titanate (BNT)‐based relaxor ferroelectrics have received much attention. Compared to other chemical elements, tantalum (Ta) doping provides superior electro‐strain for these ferroelectrics, while the effect of Ta2O5 as oxide additive has been rarely reported. Herein, lead‐free piezoceramics of Bi0.5(Na0.72K0.22Li0.06)0.5TiO3‐xTa2O5 (BNKLT‐xTa2O5, x = 0‐0.015) are synthesized. We study the effects of Ta2O5 addition on the crystal structure, piezoelectric responses, dielectric properties, and ferroelectric properties of BNKLT ceramics. All of the ceramics exhibit a typical perovskite structure, and Ta2O5 diffuses into the BNKLT lattice to form a uniform solid solution. The addition of Ta2O5 can make the grains more regular and uniform, while excess Ta2O5 result in finer grains. The undoped BNKLT ceramics show good ferroelectric and piezoelectric properties (remnant polarization Pr = 22.5 μC/cm2 and piezoelectric coefficient d33 = 250 pC/N); however, the addition of Ta2O5 leads to an clear degradation in d33 and Pr. Meanwhile, the addition of an appropriate Ta2O5 amount leads to an increase in the electro‐strain, and the unipolar strain reaches 0.385% under 60 kV/cm for x = 0.003, together with a higher normalized strain (d33*=Smax/Emax) of 633 pm/V (x = 0.003). The enhanced strain behaviors can be attributed to the coexistence of the ferroelectric and relaxor states, and an excellent electrostriction coefficient Q33 (Q33 = S/P2) value of 0.038 m4C−2 is obtained under 60 kV/cm for x = 0.003.
The prescribing needs of community practitioner nurse prescribers: A qualitative investigation using the theoretical domains framework and COM‐B
Authors: Chater Angel M. , Williams Jane , Courtenay Molly 
Published: August 2019

AbstractAimWith a number of qualified community practitioner nurse prescribers (CPNPs) not prescribing, this research aimed to understand what influences this behaviour.DesignA qualitative research design.MethodsSemi‐structured interviews, based on the theoretical domains framework (TDF) were conducted with 20 CPNPs. Data collection took place between March‐July 2018 and continued until data saturation was reached.ResultsNine themes inductively explained prescribing behaviour: 1) ‘Knowledge and experience’; 2) ‘Consultation and communication skills’; 3) ‘Professional confidence and identity’; 4) ‘Wanting the best outcome’; 5) ‘NHS versus patient cost’; 6) ‘Emotion‐led decisions’; 7) ‘Time allocation’; 8) ‘Formulary access’ and 9) ‘Supporting environment for patient‐centred care’. Themes were then deductively mapped to the TDF and COM‐B.ConclusionThere is an ongoing need to support community practitioner nurse prescribers’ ‘Capability’ to prescribe in terms of knowledge and aquired skills; ‘Opportunity’ to make prescribing easier, such as access to a wider and up to date nurse formulary alongside effective clinical support; and ‘Motivation’ to feel confident in prescribing behaviour, highlighting positive patient outcomes while reducing perceived issues such as cost and non‐adherence.ImpactFindings show that Capability, Opportunity and Motivation all influence the decision to prescribe. Those responsible for professional regulation and training should ensure community practitioner nurse prescribers have access to the relevant knowledge, skills and formulary to facilitate their prescribing behaviour. Professional confidence and identity as a prescriber should be encouraged, with acknowledgment of influences such as cost and emotion. An environment that allows for patient‐centred care and the best outcome should be supported, this may mean increasing time allocated to consultations.
Experimental verification of the value of the Tpeak–Tend interval in ventricular arrhythmia inducibility in an early repolarization syndrome model
Authors: Yoon Namsik , Hong Seo Na , Cho Jeong Gwan , Jeong Hyung Ki , Lee Ki Hong , Park Hyung Wook 
Published: August 2019

AbstractIntroductionIn patients with early repolarization patterns on ECG, many researchers have studied to find predictors of fatal arrhythmia. However, there are no satisfying clinical predictors. We evaluated the value of the Tpeak–Tend interval on pseudo‐ECG in canine myocardial wedge preparation models of early repolarization syndrome.Methods and ResultsTransmural pseudo‐ECG and endocardial/epicardial action potentials were recorded from coronary‐perfused canine left ventricular wedge preparations (n = 34). The Ito agonist NS5806 (8‐10 µM), the calcium channel blocker verapamil (3 µM) and acetylcholine (2‐3 µM) were used to mimic the disease model. A ventricular arrhythmia induction test was performed. QTpeak, QTend, Tpeak–Tend, and Tpeak–Tend/QTend were measured at 15 to 20 minutes after the provocative agent infusion. Polymorphic ventricular tachycardias (pVT) developed in 23 of the 34 preparations (67%). The maximal values of Tpeak–Tend and Tpeak–Tend/QTend were recorded just before pVT induction. At baseline, without the provocative agents, Tpeak–Tend and Tpeak–Tend/QTend were not different between pVT‐induced and pVT‐noninduced preparations. The Tpeak–Tend of the pVT‐induced preparations was longer than that of non‐induced preparations (58 ± 26.8 msec vs 33 ± 6.8 msec, P < .001). The Tpeak–Tend/QTend of pVT‐ induced preparations was larger than that of noninduced preparations (0.220 ± 0.1017 vs 0.128 ± 0.0312, P < .001). The transmural and epicardial dispersion of repolarization of pVT‐induced preparations were larger than those of pVT‐noninduced preparations. The transmural dispersion of repolarization showed a positive correlation with Tpeak–Tend.ConclusionTpeak–Tend predicted malignant ventricular arrhythmias in early repolarization syndrome models. Tpeak–Tend reflects the repolarization heterogeneity of ventricular myocardium.
circCPA4 acts as a prognostic factor and regulates the proliferation and metastasis of glioma
Authors: Peng Hao , Qin Chaoying , Zhang Chao , Su Jun , Xiao Qun , Xiao Yao , Xiao Kai , Liu Qing 
Published: August 2019

AbstractCircular RNAs (circRNAs) are reported to play vital roles in tumour process and might be potential prognostic biomarkers and therapeutic targets for tumours. But the expression and function of circRNAs in glioma remain unclear. Here, we performed circRNA microarray analysis of glioma tissues and matched normal brain tissue samples to explore the circRNA profile in glioma. GO analysis, KEGG and Reactom pathway analysis of linear mRNA transcripts corresponding to circRNAs were performed to study the involved biological process and pathways. The clinical significance of the selected circRNA was investigated by Kaplan‐Meier survival analysis. Relevant biological function, such as cell proliferation and metastasis, was detected in vitro and in vivo. And possible mechanism of the regulatory function of the selected circRNA in glioma was explored. We found that circCPA4 (hsa_circ_0082374) up‐regulated the most in glioma tissues and high levels of circCPA4 were positively related to poor outcome of glioma. And knockdown of circCPA4 suppresses cell proliferation and metastasis in glioma. Moreover, circCPA4 interacts with let‐7 and serves as a sponge for let‐7. Through the competitive endogenous RNA (ceRNA) mechanism, circCPA4 sponges let‐7 to regulate the expression of CPA4 and glioma progression. The circCPA4/let‐7/CPA4 axis regulates glioma progression by ceRNA mechanism, and circCPA4 could be a novel prognostic biomarker and target for glioma treatment.
Establishment the critical control point methodologies of seven major food processes in the catering industry to meet the core concepts of ISO 22000:2018 based on the Taiwanese experience
Authors: Chen Hsinjung , Chen Yijuan , Liu Shihlun , Yang Huiting , Chen Chinshuh , Chen Yuhshuen 
Published: August 2019

AbstractThis study focused on significant hazard analysis, the determination and establishment of prerequisite programs, and the role of critical control point (CCP) based on ISO 22000:2018, providing guidelines and experiences related to the incorporation of significant hazard analysis and the use of the CCP decision tree approach to determine and update the possible CCPs of seven primary food processes in the catering industry so as to adhere to the core concept of ISO 22000:2018.Practical ApplicationsThe revised ISO 22000:2018 guideline regarding food safety management systems has been widely implemented by small‐ and medium‐sized catering companies around the world because it suggests appropriate measures for risk management, corporate operations, and the reinforcement of autonomous management that help companies to nip food catering service safety risks in the bud.
Preoperative prediction of futile surgery in patients with radiologically resectable or borderline resectable pancreatic adenocarcinoma
Authors: Lee Hee Seung , An Chansik , Hwang Ho Kyoung , Roh Yun Ho , Kang Huapyong , Jo Jung Hyun , Chung Moon Jae , Park Jeong Youp , Kang Chang Moo , Park Seung Woo , Yoon Dong Sup , Lee Woo Jung , Song Si Young , Bang Seungmin 
Published: August 2019

AbstractBackground and AimThe aim of this study is to identify the predictive factors for futile surgery in patients with radiologically resectable or borderline resectable pancreatic cancer and to develop a prediction model.MethodsThis retrospective study included patients who underwent pancreatic surgery for pancreatic cancer between 2006 and 2017. To identify independent risk factors for futile surgery, logistic regression and random forest analyses were performed in the training cohort, based on which a nomogram was established. The predictive accuracy and discriminative ability of the nomogram were validated in the validation cohort.ResultsOf 389 patients who underwent pancreatic surgery, the laparotomy was futile in 40 patients (10.3%). In the training cohort, the univariate and multivariate logistic regression analyses revealed that serum carbohydrate antigen 19‐9 level of ≥ 150 U/mL (P = 0.003), the presence of suspicious lymph node (P = 0.013), and more extensive peripancreatic tumor infiltration (P < 0.001) were independent predictive factors for futile surgery. The bootstrap‐corrected concordance index of the nomogram was high in the training cohort, 0.826 with a 95% confidence interval of 0.745–0.907. This model also showed a good discriminative performance in the validation cohort, with a concordance index of 0.831.ConclusionsWe established and validated a novel nomogram that predicts the risk of futile surgery due to occult distant metastasis in patients with radiologically resectable or borderline resectable pancreatic cancer.
Health Literacy Matters More Than Experience for Advance Care Planning Knowledge Among Older Adults
Authors: Nouri Sarah S. , Barnes Deborah E. , Volow Aiesha M. , McMahan Ryan D. , Kushel Margot , Jin Chengshi , Boscardin John , Sudore Rebecca L. 
Published: August 2019

BACKGROUNDAdvance care planning (ACP) engagement is low among vulnerable populations, including those with limited health literacy (LHL). Limited knowledge about ACP may be a modifiable mediator of the relationship between LHL and ACP. Our goal was to determine whether health literacy is associated with ACP knowledge.DESIGNCross‐sectional design.SETTINGA public health delivery system and Veterans Affairs Medical Center in San Francisco, CA.PARTICIPANTSEnglish‐ and Spanish‐speaking patients (N = 1400).MEASUREMENTSACP knowledge was assessed with seven validated multiple‐choice questions. Health literacy was measured using a validated scale. Sociodemographic measures included age, sex, language, education, race, health status, and social support. Prior ACP experience was defined as having documented legal forms and/or goals‐of‐care discussions in the medical record. We used Kruskal‐Wallis tests and linear regression to examine associations of ACP knowledge with LHL, prior ACP experience, and sociodemographic factors.RESULTSMean age of participants was 65 (±10) years, 48% were women, 34% had LHL, 32% were Spanish speaking, 47% had high school education or less, and 70% were nonwhite. Mean 7‐point knowledge scores were lower for those with limited vs adequate health literacy (3.8 [SD = 1.9 vs 5.5 (SD = 1.7); P < .001). In multivariable analysis, ACP knowledge scores were 1.0 point lower among those with LHL; 0.6 points lower among Spanish speakers and those with high school education or less; and 0.5 points lower among individuals of nonwhite race (P < .001 for all). Knowledge scores were 0.02 points lower per year of older age (P = .007) and 0.01 points higher per point of greater social support (P = .005). Prior ACP experience was not associated with knowledge after adjustment (P = .7).CONCLUSIONSHealth literacy and sociodemographics are stronger predictors than prior ACP experience of ACP knowledge. This study suggests that providing easy‐to‐understand ACP materials is paramount and should be offered even if patients have previous experience with the ACP process. J Am Geriatr Soc 67:2151–2156, 2019
Induction of systemic resistance in tomato against broomrape (Phelipanche aegyptiaca)
Authors: Borzouei Shahla , Sharifi Rouhallah , Moarrefzadeh Nahid 
Published: August 2019

AbstractRhizosphere dwelling bacteria can increase plant resistance to biotic and abiotic stresses, and they promote plant growth through various mechanisms. In this study, three bioassays were conducted including the following: (a) screening for effective bacterial isolates in the suppression of broomrape, (b) evaluating induced systemic resistance against broomrape and (c) comparing the selected bacterium isolate with plant chemical inducers. Fifteen plant growth‐promoting rhizobacteria (PGPR) were examined to assess their biocontrol potential against Egyptian broomrape (Phelipanche aegyptiaca). Ten isolates significantly reduced the broomrape biomass compared to the control. The Lysinibacillus boronitolerans B124 reduced the dry weight of broomrape plants from 2.15 g in control to 0.45 g. Bacillus megaterium B6 was the best isolate in reducing the number of broomrape tubercles. In addition, the activity of three selected bacterial isolates was investigated in induced systemic resistance to broomrape by split‐root method. The Bacillus pumilus INR7 reduced the number of visible broomrape tubercles by 90%, and B. megaterium B71 and L. boronitolerans B124 were the next two in rank. Compared with the control, L. boronitolerans B124 reduced the dry weight of broomrape from 1.49 g in control to 0.39 g. In a subsequent experiment, L. boronitolerans B124 was evaluated along with some resistance‐inducing volatile compounds. Lysinibacillus boronitolerans B124 decreased the number of broomrapes by 87% on average, while the lowest dry weight of broomrape was observed in methyl jasmonate treatment. In conclusion, PGPR have considerable potential to be used in the integrated management of broomrape. It is also possible to use a mixture of rhizobacteria and defence inducers, such as biogenic volatiles as a promising approach in the management of this noxious parasitic weed.