bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased local failure for patients with intermediate‐risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group
Authors: Casey Dana L. , Chi Yueh‐Yun , Donaldson Sarah S. , Hawkins Douglas S. , Tian Jing , Arndt Carola A. , Rodeberg David A. , Routh Jonathan C. , Lautz Timothy B. , Gupta Abha A. , Yock Torunn I. , Wolden Suzanne L. 
Published: June 2019

BackgroundThe objective of this study was to evaluate local control for patients with intermediate‐risk rhabdomyosarcoma (RMS) treated on Children's Oncology Group (COG) protocol ARST0531.MethodsThis study analyzed 424 patients with intermediate‐risk RMS. Patients were randomized to chemotherapy with either vincristine, dactinomycin, and cyclophosphamide (VAC) or VAC alternating with vincristine and irinotecan. With the goal of improving local control, radiation therapy (RT) was delivered early at week 4 and was concurrent with irinotecan in the experimental arm. Individualized local control plans for children 24 months old or younger were allowed. Local failure on ARST0531 was compared with local failure on the preceding COG intermediate‐risk study, D9803.ResultsFor patients with group I/II alveolar RMS (n = 55), the 5‐year cumulative incidence of local failure was 13.4%; for group III alveolar RMS (n = 141), it was 20.2%; and for group III embryonal RMS (n = 228), it was 27.9% (P = .03). Among patients with group III disease, local failure did not differ by histology, site, nodal status, RT modality, or treatment arm. Local failure was worse for a tumor size >5 cm (32.3% vs 16.7%; P = .001). Among patients with group III embryonal RMS, local failure was higher on ARST0531 than D9803 (27.9% vs 19.4%; P = .03). After the exclusion of patients 24 months old or younger or patients who did not receive radiation, local failure remained significantly increased on ARST0531 (P = .02). After adjustments for clinical prognostic factors, event‐free survival and overall survival were worse on ARST0531 (P = .004 and P = .05, respectively).ConclusionsDespite interventions designed to enhance local control, local control was inferior on ARST0531 in comparison with D9803. The reason for this is unclear, but it could be the reduced cyclophosphamide dose on ARST0531.
Amygdala growth from youth to adulthood in the macaque monkey
Authors: Schumann Cynthia M. , Scott Julia A. , Lee Aaron , Bauman Melissa D. , Amaral David G. 
Published: June 2019

AbstractEmerging evidence suggests that the human amygdala undergoes extensive growth through adolescence, coinciding with the acquisition of complex socioemotional learning. Our objective was to longitudinally map volumetric growth of the nonhuman primate amygdala in a controlled, naturalistic social environment from birth to adulthood. Magnetic resonance images were collected at five time‐points in 24 male and female rhesus macaques from 6 months to adulthood at 5 years. We then compared amygdala growth to other brain regions, including newly collected isocortical gray and white matter volumes, and previously published data on the same cohort. We found that amygdala volume increases by nearly 50% from age 6 months to 5 years. This dramatic growth is in contrast to overall brain and hippocampal volume, which peak near 3 years, white matter, which slows from 3 to 5 years, and isocortical gray, which has a net decrease. Similar to isocortical gray and hippocampal volumes, amygdala volume is ~8% larger in males than females. Rate of growth does not differ by sex. Although the underlying neurobiological substrate for protracted amygdala growth into adulthood is unclear, we propose it may be due in part to the unique cellular development of immature neurons in paralaminar nucleus that mature in size and connectivity with age. Prolonged amygdala maturation raises the possibility that environmental and genetic perturbations that disrupt this trajectory may contribute to the emergence of psychiatric disorders, such as anxiety, depression, schizophrenia, and autism; all in which the amygdala is strongly implicated.
Software defined vehicular networks: A comprehensive review
Authors: Bhatia Jitendra , Modi Yash , Tanwar Sudeep , Bhavsar Madhuri 
Published: June 2019

SummaryThe recent breakthroughs in the automobile industries and telecommunication technologies along with the exceptional multimodal mobility services brought focus on intelligent transportation system (ITS), of which vehicular ad hoc networks (VANETs) gain much more attention. The distinctive features of software‐defined networking (SDN) leverages the vehicular networks by its state of the centralized art having a comprehensive view of the network. Its potential to bring the flexibility, programmability and other extensive advancements to vehicular networks has set the stage for a novel networking paradigm termed as software‐defined vehicular networks (SDVNs). Many researchers have demonstrated the SDN‐based VANETs with the various configuration of the SDN components in VANET architecture. However, a compilation of the work on the SDN‐based VANET system as a whole, incorporating its architecture, use‐cases, and opportunities, is still inadequate. We start with the summary of the recent studies that exist on the SDVNs, followed by the comprehensive explanation of its components. Next, we present the taxonomy of SDVN based on the architecture modes, protocols, access technologies, and opportunities with trending technologies. Finally, we highlight the challenges, open research issues, and future research directions.
Cutaneous nocardiosis with discharging sinus clinically mimicking tuberculosis diagnosed by cytology
Authors: Gudivada Vijayalakshmi , Gochhait Debasis , Bhandary Chandni , Mishra Nimesh , Siddaraju Neelaiah 
Published: June 2019

AbstractNocardiosis is primarily a pulmonary infection commonly seen in immunocompromised individuals. However, lymphocutaneous nocardiosis is observed in immunocompetent individuals often after trauma. The clinical and cytomorphological features of lymphocutaneous nocardiosis closely mimic the most common infections in India such as tuberculosis and mycetoma (very common cutaneous infection with discharging sinus). As it is crucial to differentiate nocardiosis from tuberculosis, to avoid unnecessary antitubercular treatment, special stains like modified Ziehl–Neelsen stain and Gram stain can be employed to differentiate the morphology of Nocardia from tuberculosis. Fine‐needle cytology from these cutaneous lesions helps in yielding adequate material for rapid and accurate diagnosis of immediate specific antibiotic treatment. We report a rare case that presented with clinical diagnosis of tuberculosis but turned out to be nocardiosis on cytomorphology with simple and most feasible fine‐needle aspiration method of tissue diagnosis and scrape cytology.
Effects of a herbicide on paddy predatory insects depend on their microhabitat use and an insecticide application
Authors: Hashimoto Koya , Eguchi Yuji , Oishi Hiroki , Tazunoki Yuhei , Tokuda Makoto , Sánchez‐Bayo Francisco , Goka Koichi , Hayasaka Daisuke 
Published: June 2019

AbstractIndirect effects of agrochemicals on organisms via biotic interactions are less studied than direct chemical toxicity despite their potential relevance in agricultural landscapes. In particular, the role of species traits in characterizing indirect effects of pesticides has been largely overlooked. Moreover, it is still unclear whether such indirect effects on organisms are prevalent even when the organisms are exposed to direct toxicity. We conducted a mesocosm experiment to examine indirect effects of a herbicide (pentoxazone) on aquatic predatory insects of rice paddies. Because the herbicide selectively controls photosynthetic organisms, we assumed that the effects of the herbicide on predatory insects would be indirect. We hypothesized that phytophilous predators such as some Odonata larvae, which cling to aquatic macrophytes, would be more subject to negative indirect effects of the herbicide through a decrease in abundance of aquatic macrophytes than benthic, nektonic, and neustonic predators. Also, we crossed‐applied an insecticide (fipronil) with herbicide application to examine whether the indirect effects of the herbicide on the assembling predators act additively with direct adverse effects of the insecticide. The herbicide application did not decrease the abundance of phytoplankton constitutively, and there were no clear negative impacts of the herbicide on zooplankton and prey insects (detritivores and herbivores). However, the abundance of aquatic macrophytes was significantly decreased by the herbicide application. Although indirect effects of the herbicide were not so strong on most predators, their magnitude and sign differed markedly among predator species. In particular, the abundance of phytophilous predators was more likely to decrease than that of benthic, nektonic, and neustonic predators when the herbicide was applied. However, these indirect effects of the herbicide could not be detected when the insecticide was also applied, seemingly due to fipronil's high lethal toxicity. Our study highlights the importance of species traits such as microhabitat use, which characterize biotic interactions, for predicting indirect effects of agrochemicals. Given that indirect effects of the chemicals vary in response to species traits and direct toxicity of other chemicals, efforts to explain this variation are needed to predict the realistic risks of indirect effects of agrochemicals in nature.
Urban meadows as an alternative to short mown grassland: effects of composition and height on biodiversity
Authors: Norton Briony A. , Bending Gary D. , Clark Rachel , Corstanje Ron , Dunnett Nigel , Evans Karl L. , Grafius Darren R. , Gravestock Emily , Grice Samuel M. , Harris Jim A. , Hilton Sally , Hoyle Helen , Lim Edward , Mercer Theresa G. , Pawlett Mark , Pescott Oliver L. , Richards J. Paul , Southon Georgina E. , Warren Philip H. 
Published: June 2019

AbstractThere are increasing calls to provide greenspace in urban areas, yet the ecological quality, as well as quantity, of greenspace is important. Short mown grassland designed for recreational use is the dominant form of urban greenspace in temperate regions but requires considerable maintenance and typically provides limited habitat value for most taxa. Alternatives are increasingly proposed, but the biodiversity potential of these is not well understood. In a replicated experiment across six public urban greenspaces, we used nine different perennial meadow plantings to quantify the relative roles of floristic diversity and height of sown meadows on the richness and composition of three taxonomic groups: plants, invertebrates, and soil microbes. We found that all meadow treatments were colonized by plant species not sown in the plots, suggesting that establishing sown meadows does not preclude further locally determined grassland development if management is appropriate. Colonizing species were rarer in taller and more diverse plots, indicating competition may limit invasion rates. Urban meadow treatments contained invertebrate and microbial communities that differed from mown grassland. Invertebrate taxa responded to changes in both height and richness of meadow vegetation, but most orders were more abundant where vegetation height was longer than mown grassland. Order richness also increased in longer vegetation and Coleoptera family richness increased with plant diversity in summer. Microbial community composition seems sensitive to plant species composition at the soil surface (0–10 cm), but in deeper soils (11–20 cm) community variation was most responsive to plant height, with bacteria and fungi responding differently. In addition to improving local residents’ site satisfaction, native perennial meadow plantings can produce biologically diverse grasslands that support richer and more abundant invertebrate communities, and restructured plant, invertebrate, and soil microbial communities compared with short mown grassland. Our results suggest that diversification of urban greenspace by planting urban meadows in place of some mown amenity grassland is likely to generate substantial biodiversity benefits, with a mosaic of meadow types likely to maximize such benefits.
Benthification, biotic homogenization behind the trophic downgrading in altered ecosystems
Authors: Bezerra Luis Artur Valões , Ribeiro Vanessa Maria , Freitas Matheus Oliveira , Kaufman Les , Padial Andre Andrian , Vitule Jean Ricardo Simões 
Published: June 2019

AbstractSeveral dozen fish species have been introduced into Neotropical waters, causing significant biotic changes that include deterministic predation interactions with ecosystem effects. In general, reservoirs are preferred over lakes as places for stocking policies, due to their artificial aspect, consequently promoting fish introductions. In a meta‐analytic approach, we compared the biomass of plankton‐feeding (and top predators) with bottom‐feeding fish species between reservoirs and lakes, considering the influence of invaders and trophic levels. Among the 26 ecosystems (12 reservoirs and 14 lakes), there is a dominance of non‐native bottom‐feeding species in artificial environments. We revealed a mechanism behind this dominance in a study case, a tendency for trophic downgrading and biotic homogenization based on interactions between an expatriate invasive centrarchid (sunfish family) predator from North America (the largemouth bass Micropterus salmoides) and two omnivorous cichlids from Africa in novel environmental contexts in Brazil (the benthification process). Both juvenile and adult largemouth bass are keystone predators in aquatic food webs in both their native and introduced ranges. The omnivore–detritivore tilapiines Oreochromis spp. and the phytophagous–omnivorous Coptodon spp. are species that exhibits strong generalist tendencies. Such species feed on the omnivore and detritivore compartments, enhancing detritus cycling among a large variety of δ13C sources. Since their consumption is disproportionate, facilitation of other species occurs with multiplicative effects in the environment. Interactions between invasive species, that is, when an invasive predator (bird, fish, or invertebrate) eats an invasive prey (mainly fish and invertebrates), can serve to highlight biotic homogenization on fresh waters.
Numerical response of a mammalian specialist predator to multiple prey dynamics in Mediterranean farmlands
Authors: Mougeot François , Lambin Xavier , Rodríguez‐Pastor Ruth , Romairone Juan , Luque‐Larena Juan‐José 
Published: June 2019

AbstractThe study of rodent population cycles has greatly contributed, both theoretically and empirically, to our understanding of the circumstances under which predator–prey interactions destabilize populations. According to the specialist predator hypothesis, reciprocal interactions between voles and small predators that specialize on voles, such as weasels, can cause multiannual cycles. A fundamental feature of classical weasel–vole models is a long time‐lag in the numerical response of the predator to variations in prey abundance: weasel abundance increases with that of voles and peaks approximately 1 yr later. We investigated the numerical response of the common weasel (Mustela nivalis) to fluctuating abundances of common voles (Microtus arvalis) in recently colonized agrosteppes of Castilla‐y‐Léon, northwestern Spain, at the southern limit of the species’ range. Populations of both weasels and voles exhibited multiannual cycles with a 3‐yr period. Weasels responded quickly and numerically to changes in common‐vole abundance, with a time lag between prey and weasel abundance that did not exceed 4 months and occurred during the breeding season, reflecting the quick conversion of prey into predator offspring and/or immigration to sites with high vole populations. We found no evidence of a sustained, high weasel abundance following vole abundance peaks. Weasel population growth rates showed spatial synchrony across study sites approximately 60 km apart. Weasel dynamics were more synchronized with that of common voles than with other prey species (mice or shrews). However, asynchrony within, as well as among sites, in the abundance of voles and alternative prey suggests that weasel mobility could allow them to avoid starvation during low‐vole phases, precluding the emergence of prolonged time lag in the numerical response to voles. Our observations are inconsistent with the specialist predator hypothesis as currently formulated, and suggest that weasels might follow rather than cause the vole cycles in northwestern Spain. The reliance of a specialized predator on a functional group of prey such as small rodents does not necessarily lead to a long delay in the numerical response by the predator, depending on the spatial and interspecific synchrony in prey dynamics.
How geomorphic context governs the influence of wildfire on floodplain organic carbon in fire‐prone environments of the western United States
Authors: Wohl Ellen , Lininger Katherine B. , Rathburn Sara L. , Sutfin Nicholas A. 
Published: June 2019

AbstractWe draw on published studies of floodplain organic carbon storage, wildfire‐related effects on floodplains in temperate and high latitudes, and case studies to propose a conceptual model of the effects of wildfire on floodplain organic carbon storage in relation to climate and valley geometry. Soil organic carbon typically constitutes the largest carbon stock in floodplains in fire‐prone regions, although downed wood can contain significant organic carbon. We focus on the influence of wildfire on soil organic carbon and downed wood as opposed to standing vegetation to emphasize the geomorphic influences resulting from wildfire on floodplain organic carbon stocks. The net effect of wildfire varies depending on site‐specific characteristics including climate and valley geometry. Wildfire is likely to reduce carbon stock in steep, confined valley segments because increased water and sediment yields following fire create net floodplain erosion. The net effect of fire in partly confined valleys depends on site‐specific interactions among floodplain aggradation and erosion, and, in high‐latitude regions, permafrost degradation. In unconfined valleys in temperate latitudes, wildfire is likely to slightly increase floodplain organic carbon stock as a result of floodplain aggradation and wood deposition. In unconfined valleys in high latitudes underlain by permafrost, wildfire is likely in the short‐term to significantly decrease floodplain organic carbon via permafrost degradation and reduce organic‐layer thickness. Permafrost degradation reduces floodplain erosional resistance, leading to enhanced stream bank erosion and greater carbon fluxes into channels. The implications of warming climate and increased wildfires for floodplain organic carbon stock thus vary. Increasing wildfire extent, frequency, and severity may result in significant redistribution of organic carbon from floodplains to the atmosphere via combustion in all environments examined here, as well as redistribution from upper to lower portions of watersheds in the temperate zone and from floodplains to the oceans via riverine transport in the high‐latitudes. © 2019 John Wiley & Sons, Ltd.
Modeling boulder transport by coastal waves on cliff topography: Case study at Hachijo Island, Japan
Authors: Watanabe Masashi , Goto Kazuhisa , Imamura Fumihiko , Kennedy Andrew , Sugawara Daisuke , Nakamura Norihiro , Tonosaki Takayuki 
Published: June 2019

AbstractClifftop coastal boulders transported by storm waves or tsunamis have been reported around the world. Although numerical calculation of boulder transport is a strong tool for the identification of tsunami or storm boulders, and for estimation of the wave size emplacing boulders, models which can reasonably solve boulder transport from below a cliff or from a cliff‐edge onto a cliff‐top do not yet exist. In this study, we developed a new numerical formulation for cliff‐top deposition of boulders from the cliff edge or below the cliff, with validation from laboratory tests. We then applied the model using storm and tsunami wave forcing to simulate the observed boulder deposits at the northwest coast of Hachijo Island, Japan. Using the model, the actual distribution of boulders was explained well using a reasonable storm wave height without assumption of anomalously high‐water level by storm surge. Results show that boulder transport from the cliff edge or under the cliff onto the cliff‐top was possible from a tsunami with periods of 5~10 min or storm waves with no storm surge. However, the actual distribution of boulders on the cliff was explained only by storm waves, but not by tsunami. Therefore, the boulders distributed at this site are likely of storm wave origin. Our developed model for the boulder transport calculation can be useful for identifying a boulder's origin and can reasonably calculate cliff‐top deposition of boulders by tsunami and storm waves. © 2019 John Wiley & Sons, Ltd. © 2019 John Wiley & Sons, Ltd.
A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals
Authors: Carlson Jenna C. , Anand Deepti , Butali Azeez , Buxo Carmen J. , Christensen Kaare , Deleyiannis Frederic , Hecht Jacqueline T. , Moreno Lina M. , Orioli Ieda M. , Padilla Carmencita , Shaffer John R. , Vieira Alexandre R. , Wehby George L. , Weinberg Seth M. , Murray Jeffrey C. , Beaty Terri H. , Saadi Irfan , Lachke Salil A. , Marazita Mary L. , Feingold Eleanor , Leslie Elizabeth J. 
Published: June 2019

AbstractPhenotypic heterogeneity is a hallmark of complex traits, and genetic studies of such traits may focus on them as a single diagnostic entity or by analyzing specific components. For example, in orofacial clefting (OFC), three subtypes—cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP) have been studied separately and in combination. To further dissect the genetic architecture of OFCs and how a given associated locus may be contributing to distinct subtypes of a trait we developed a framework for quantifying and interpreting evidence of subtype‐specific or shared genetic effects in complex traits. We applied this technique to create a “cleft map” of the association of 30 genetic loci with three OFC subtypes. In addition to new associations, we found loci with subtype‐specific effects (e.g.,GRHL3[CP],WNT5A[CLP]), as well as loci associated with two or all three subtypes. We cross‐referenced these results with mouse craniofacial gene expression datasets, which identified additional promising candidate genes. However, we found no strong correlation between OFC subtypes and expression patterns. In aggregate, the cleft map revealed that neither subtype‐specific nor shared genetic effects operate in isolation in OFC architecture. Our approach can be easily applied to any complex trait with distinct phenotypic subgroups.