bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TELESSAÚDE COMO FERRAMENTA NA EDUCAÇÃO CONTINUADA PARA O DIAGNÓSTICO PRECOCE DO CÂNCER INFANTOJUVENIL
Authors: Barros MARIANA Boulitreau Siqueira Campos , Vicente Débora Rafaelly da Silva , Bushatsky Magaly , E Silva Débhora Ísis Barbosa , Coutinho Natália Maria Penha , De Morais Vera Lúcia Lins , Diniz Paula Rejane Beserra , De Santana Jocastra Bispo , Melo Raul Antônio Morais , Novaes Magdala de Araujo 
Published: August 2018

RESUMOINTRODUÇÃO: O câncer infantojuvenil vem se apresentando como a segunda causa de óbito na população entre 0 e 19 anos no Brasil, atrás apenas das causas externas. As tecnologias de informação e comunicação, especificamente, a telessaúde, revela-se uma mola propulsora na triagem de suspeitas de neoplasias malignas, além de promover a integração da equipe da atenção primária à saúde e a do centro de referência, diminuindo distâncias, e promovendo educação continuada igualitária.OBJETIVO: Associar os resultados do pré e pós-testes e descrever as teleconsultorias enviadas após a intervenção do projeto FIQUE ATENTO: PODE SER CÂNCER: A telessaúde como ferramenta para a suspeição precoce do câncer infantojuvenil, realizado com profissionais da atenção primária à saúde em Recife-Pernambuco.MÉTODO: Trata-se de um estudo quase-experimental sem grupo controle, descritivo, com abordagem quantitativa. Realizado nos anos de 2015 e 2016, a partir da análise de dados secundários da Plataforma de Telessaúde HealthNET da RedeNutes, do Núcleo de Telessaúde da Universidade Federal de Pernambuco. Utilizou-se o software EpiInfo 7.2 como suporte estatístico para o cálculo das frequências absolutas e relativas, assim como para as medidas de associação. Adotou-se o p-valor menor que 0,05 para o cálculo de significância estatística. O projeto foi aprovado sob o número do CAAE 50707515.7.0000.5208.RESULTADOS: Os profissionais, após a intervenção, mostraram maior desenvolvimento com relação aos conhecimentos obtidos sobre epidemiologia (p<0,001), e sinais e sintomas das neoplasias infantojuvenis (p<0,001). Foram geradas oito teleconsultorias com tempo médio de resposta de 53,32 horas, em que 50% (4) foram casos clínicos e tiveram seus encaminhamentos qualificados, e nenhum precisou ser regulado à unidade de referência.CONCLUSÃO: A telessaúde mostra-se como uma ferramenta com potencial de educação permanente, contribuindo para o diagnóstico precoce do câncer infantojuvenil, aumentando as chances de cura e sobrevida. Palavras-chave: Saúde da Criança; Saúde do Adolescente; Neoplasias; Telessaúde; Atenção primária à saúde.
An acoustic study of phonological phrases containing sequences of words with adjacent primary-stressed syllables: does stress shift occur in brazilian portuguese?
Authors: Madureira Sandra 
Published: August 2018

O objetivo deste trabalho é discutir o fenômeno de deslocamento acentual (stress shift) em português brasileiro como postulado pela Regra do Ritmo (Rhythm Rule), fundamentando-se em evidência acústica provinda sobretudo da análise de contornos de freqüência fundamental de sintagmas fonológicos contendo seqüências de palavras em condição ou não de encontro acentual (stress clash). Para o propósito da presente discussão, seis frases de três dos corpora designados para a investigação do fenômeno são considerados. Três locutores do português brasileiro foram gravados produzindo cinco repetições de cada frase. Os resultados mostram que não há diferença entre contornos de f0 das duas condições em contraste e somente uma diferença de alinhamento de pico de f0 ocorre, dependendo este do tipo de padrão acentual lexical (oxítono ou paroxítono) da segunda palavra do sintagma. Aspectos ligados a diferenças interlingüísticas são discutidos.
Failure and Fatigue Fracture at the Femoral Stem-Metaphyseal Sleeve Junction in a Modular Knee Prosthesis
Authors: Christiner Tom , Pabbruwe Moreica B. , Kuster Markus 
Published: August 2018

Case:
A 66-year-old active man had undergone revision total knee replacement surgery with a femoral metaphyseal sleeve and a cemented stem in 2013 after loosening of the implant following the primary knee arthroplasty. He was overweight and had a high activity level, and there had been progressive osteolysis surrounding the distal aspect of the femoral sleeve. In 2017, the metaphyseal sleeve had loosened, resulting in corrosion of the threaded taper and catastrophic failure of the implant, with a fracture of the stem at the junction of the sleeve.

Conclusion:
This unique method of failure in this knee implant highlights a weak point in the design. Clinicians must be aware of the increased likelihood of this type of failure with these implants in patients who have contributory factors.
ATRIBUTOS PESSOAIS DA CULTURA DA HOSPITALIDADE: APLICAÇÃO AOS ESTUDANTES DE ENSINO SUPERIOR EM PORTUGAL
Authors: Fernandes Adriana Lopes , Fonseca Drielle de Santana , Ribeiro Lílian Ponzo 
Published: August 2018

Esta pesquisa teve como objetivo compreender se a formação oferecida pelas instituições de ensino superior portuguesas, voltadas para a hospitalidade e gestão hoteleira, é capaz de desenvolver nos estudantes os atributos pessoais necessários e desejados aos profissionais da indústria da hotelaria. Relativamente à metodologia, foi realizado um survey com estudantes de gestão hoteleira ou equivalente. O instrumento utilizado na coleta dos dados foi devidamente traduzido e adaptado do inglês para a língua portuguesa e distribuído online por meio da plataforma Limesurvey. A amostra foi composta de 112 estudantes de graduação e mestrado. Os dados foram classificados e analisados utilizando-se o software IBM SPSS Statistics. Os resultados apontam que embora haja preocupação das instituições portuguesas na formação técnica, o escore dos estudantes foi um pouco abaixo do esperado para profissionais dessa indústria. Concluiu-se que as instituições de ensino portuguesas, principalmente ao nível da graduação, precisam criar estratégias capazes de desenvolver nos estudantes atributos necessários ao trabalho nessa indústria, de forma a evitar um problema já nela existente, que é a alta rotatividade.
Identification of Xanthine Derivatives as Inhibitors of Phosphodiesterase 9A Through In silico and Biological Studies
Authors: Singh Nivedita , Patra Swagata , Patra Sanjukta 
Published: August 2018

Background:
In recent times, computer aided methodologies have received broad
attention in drug development. These studies have improved the accuracy and shortened the time
frame to identify suitable drug candidates from large datasets. Xanthine is a plant alkaloid which also
acts as an intermediate product on the pathway of purine degradation. Xanthine acts as scaffold for
various natural and synthetically derived bioactive molecules.

Objective:
The present work aims to screen xanthine derivatives targeting phosphodiesterase 9A
(PDE9A), one of the most important regulatory protein of signal transduction.

Method:
In silico approach such as Virtual screening, molecular docking and molecular dynamic
was attempted to screen a repertoire of 2055 xanthine derivatives extracted from ZINC database
against PDE9A. The potency of the resultant screened compound was finally validated by
spectrophotometric malachite green inhibition assay.

Results:
Preliminary virtual screening narrowed down the compounds to a list of 10 which is
followed by a second round of stringent screening using molecular docking approach. Top four hits
were selected for thorough interaction analysis with PDE9A. The molecular docking analysis of best
ranked compound, ZINC62579975 (-12.59) revealed its potential to establish essential chemical
interactions with inhibition determining key residues in the PDE9A active site. The stability of
ZINC62579975 in PDE9A was further validated by 6 ns molecular dynamic simulation studies. The
in vitro malachite spectrophotometric assay confirmed the bioactive potential of the above
compound. Comparative inhibition studies asserted more potency of ZINC62579975 towards
PDE9A (46.96 ± 1.78 µM) than PDE5A (61.023 ± 1.71 µM) and PDE4D (70.04 ± 1.98 µM).

Conclusion:
The entire study validates ZINC62579975 as a potent candidate molecule for PDE9A
inhibition. The present study provides a roadmap for future drug designing of more potent xanthine
derivatives. This study also explores the potential of xanthine scaffold in future drug development
process.
The Cellular Uptake and Apoptotic Efficiency of Colchicine is Correlated with Downregulation of MMP-9 mRNA Expression in SW480 Colon Cancer Cells
Authors: Ozmen Nuri , Kaya-Sezginer Ecem , Bakar-Ates Filiz 
Published: August 2018

Background:
Colchicine, a tricyclic alkaloid, is commonly used in treatment due to its antiinflammatory
and anti-fibrotic effects. Besides its toxicity at high doses, colchicine is reported for its potential
anticancer effects at lower concentrations. The present study aimed to evaluate the anticancer effects of colchicine
in SW480 cells.

Methods:
The effect of colchicine on cell proliferation was determined by MTT assay. The cellular colchicine
uptake was measured by HPLC analysis. The apoptotic effects was evaluated by annexin v binding assay and
MMP-9 mRNA expression was determined by RT-PCR experiments.

Results:
Colchicine showed significant cytotoxicity at 10 ng/ml and higher concentrations and caused a cell
cycle arrest of SW480 cells at G2/M phase. The results of HPLC analysis showed that colchicine uptake was
increased in correlation with treated concentrations. Colchicine concentrations have increased the amount of
apoptotic cell population. The elisa and western blot measurements showed that colchicine led to nuclear translocation
of NF-κB proteins and increased caspase levels. The real time PCR experiments showed that colchicine
has inhibitory effect on MMP-9 mRNA expression in a concentration dependent manner.

Conclusion:
These results illustrated that low dose colchicine efficiently induced cell death and apoptosis of
SW480 cells and the inhibition of MMP-9 mRNA levels was significantly correlated with the amount of cellular
colchicine uptake, suggesting that colchicine has a potential value in the treatment of human colorectal cancer.
Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster
Authors: Fatima Ambreen , Jyoti Smita , Siddique Yasir Hasan 
Published: August 2018

Background & Objective: Parkinson’s disease is the second most common neurodegenerative
disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD
cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases
are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an
animal model system is a valuable approach to further elucidate the roles of the genes in PD.

Conclusion:
The present review highlights the models used to study PD symptoms with special emphasis
on Drosophila.
3D Object Recognition System Based On Local Shape Descriptors and Depth Data Analysis
Authors: Chowdhary Chiranji Lal 
Published: August 2018

Background:
A physical object, which is actually in 3D form, is captured by a sensor/
camera (in case of computer vision) and seen by a human eye (in case of a human vision). When
someone is observing something, many other things are also involved there which make it more challenging
to recognize. After capturing such a thing by a camera or sensor, a digital image is formed
which is nothing other than a bunch of pixels. It is becoming important to know that how a computer
understands images.

Objective:
This paper is for highlighting novel techniques on 3D object recognition system with local
shape descriptors and depth data analysis.

Methods:
The proposed work is applied to RGBD and COIL-100 datasets and this is of four-fold as
preprocessing, feature generation, dimensionality reduction, and classification. The first stage of preprocessing
is smoothing by 2D median filtering on the depth (Z-value) and registration by orientation
correction on 3D object data. The next stage is of feature generation and having two phases of shape
map generation with shape index map and SIFT/SURF descriptors. The dimensionality reduction is the
third stage of this proposed work where linear discriminant analysis and principal component analysis
are used. The final stage is fused on classification.

Results:
Here, calculation of the discriminative subspace for the training set, testing of object data and
classification is done by comparing target and query data with different aspects for finding proper
matching tasks.

Conclusion:
This concludes with new proposed approach of 3D Object Recognition. The local shape
descriptors are used for 3D object recognition system to implement and test. This system is achieves
89.2% accuracy for Columbia object image library-100 images by using local shape descriptors.
EEG Wavelet Coherence Based Analysis of Neural Connectivity in Action Video Game Players in Attention Inhibition and Short-term Memoryretention Task
Authors: Hazarika Jupitara , Kant Piyush , Dasgupta Rajdeep , Laskar Shahedul Haque 
Published: August 2018

Background:
The involvement in action video gaming alters the cognitive abilities and
hence affects the neural functionality. Electroencephalogram (EEG) favorably provides the measure.
Wavelet coherence, which is a wavelet transform based feature that provides useful information
regarding synchronized activity between two signals. It does not depend on the stationarity of the
signal and hence very much relevant for non-stationary EEG application.

Methods:
We aimed to examine how the task-related synchronization pattern of action video game
players (AVGPs) differs from non-AVGPs. EEG data were collected from thirty-five young and
healthy male participants while performing an attention inhibition task and a visuospatial short-term
memory-retention task. The sub-frequency components, theta, alpha, beta and gamma bands of EEG
were extracted using Discrete wavelet transform (DWT). The intra and inter-hemispheric coherence
in EEG sub-frequency bands were assessed as a feature for the analysis.

Results:
Theta, alpha, beta and gamma coherence has shown a significant difference (p<0.05) between
AVGPs and non-AVGPs in both the visuo-spatial tasks in intra and inter-hemispheric functionality.
More than 90% classification accuracies are achieved with ANFIS algorithm. Results also
indicate that frontoparietal connectivity is significantly improved in AVGPs in both the visual sensory
tasks considered.

Conclusion:
These EEG based analysis reports enhanced neural communication with improved attention
inhibition and short-term memory retention in AVGPs. Result also established the Wavelet
coherence as an effective tool in understanding the neural communication among different brain locations.
Integration of Fraud Risk in the Risk of Material Misstatement and the Effect on Auditors' Planning Decisions
Authors: Popova Velina K. 
Published: August 2018

ABSTRACT
Prior research finds that although auditors assess fraud risk accurately, they generally fail to adjust audit procedures appropriately. The most recent Public Company Accounting Oversight Board (PCAOB) inspections in 2016 still identify response to risks of material misstatement (RMM) as a major area of inspection focus and cite it as a recurring audit deficiency. In this study, participants assess RMM and make audit-planning judgments in a high/low fraud risk environment using either a traditional source-based representation of RMM (i.e., based on inherent, control, and fraud risk) or a newer type-based representation of RMM (i.e., based on error and fraud risk). The results indicate that while auditors in both groups show similar sensitivity to risk, the type-based group of auditors are better able modify their audit plans by using more procedures that are new to a standard audit program and assigning more experienced staff to address high fraud risk.
Data Availability: Contact the author.
Hasil Belajar Matematika dengan Strategi Discovery Learning dan Group Investigation Ditinjau dari Keaktifan Siswa SMP
Authors: Sutama Sutama , Mayasri Atik 
Published: August 2018

The aim of observation is to analyses the effects of using learning strategies of investigation group and discovery learning base on the result of learning mathematic process, to analyses the effects of being active of students base on the result of learning mathematic process, to analyses of interaction between learning strategies of investigation group and discovery learning with being active on result of learning mathematic. The types base on scientific quantitative. Design of observation is quasi experimental. The technique of analysis data is using analysis variants two ways. Base on the result of observation, can conclude there are influence of strategies of group investigation and discovery learning for the result of learning mathematic with significant level 5%, to influence the level of being active in result of learning mathematic with significant level 5%, for the interaction between group investigation and discovery learning with significant level 5%.
Pengaruh Supervisi Kepala Sekolah dengan Teknik Kelompok (Meeting) terhadap Peningkatan Prestasi Kerja Guru di Gugus V Nakula Kecamatan Serengan Surakarta
Authors: Ismiyatun Ismiyatun 
Published: August 2018

The purposes of this research were based on the above problem statement, therefore, the purposes of the research which would be reached were: 1) To know whether there is influence of the headmaster supervision on the performance of the elementary school teachers in Gugus V Nakula of Serengan Sub-district, Surakarta; 2) To know how much the influence of the headmaster supervision on the performance of the elementary school teachers in Gugus V Nakula of Serengan Sub-district, Surakarta was. This scientific paper applied the School Action Research (PTS) that was an effort of increasing the work discipline of teachers in the teaching learning process through an individual supervision through a technique approach of class visit consisting of two cycles and each cycle consisted of four stages: (1) planning, (2) implementation of action, (3) observation/evaluatiom, and (4) reflection. This School Action Research was conducted in Elementary Schools all over Gugus V Nakula of Serengan Sub-district, Surakarta Municipality. Gugus V Nakula consisted of 5 elementary schools, 2 public elementary schools and 3 private elementary schools SMP only the national standard in the district of Nusa Penida includes two (2 ) regions and villages Desa Lembongan Jungutbatu, with the amount of students was 315 (three hundres and fifteen) students, consisting of 12 (twelve) classes, with the amount of teachers was 31 (thirty one) teachers, 3 (three) people had qualification of S2 (post graduate degree), 28 (twenty eight) people had qualification of S1 (undergraduate degree), 1 (one) person had Diploma I (D1) degree. Based on the results of data analysis, either in cycle I or cycle II, it could be concluded that 1) there was an influence of the headmaster supervision on the performance of 1-6 grades teachers in the elementary schools all over Gugus V Nakula, Serengan Sub-district, Surakarta. It was proved from the analysis scores in the cycle I which the average percentage was 67.26% which increased into 78,12%; 2) The amount of influence of the headmaster supverision on the performance of 1-6 grades teachers in the elementary schools all over Gugus V Nakula, Serengan Sub-district, Surakarta in this research was 10.86%
Peningkatan Aktivitas Belajar Dan Pemahaman Konsep Biologi Dengan Strategi Survey, Question, Read, Recite, Review (SQ3R) Pada Siswa Kelas XI IPA SMA Negeri 5 Kendari
Authors: Tendrita Miswandi 
Published: August 2018

This classroom action research is aimed at improving activities and students' understanding of biological concepts by applying the strategies SQ3R. SQ3R strategies make it possible for students to learn systematically, effectively and efficiently in the face of various teaching materials. The research was done at SMA Negeri 5 Kendari, in academic year 2013/2014. The subject of the research were 42 student that registered in the second semester of the school year 2013/2014. The data collecting method were done by using interview and observation. Source data from this study was the measurement of student learning activities using observation sheet comprehension test and measurement concept that refers to indicators of understanding of the concept according to Anderson and Krathwoll in the first cycle, second cycle and third cycle. The data analysis was done by descriptive statistics. The research concludes that: 1) The percentage score activitiies students in first cycle is 77,08, second cycle is 82,14%, and the three cycle is 86,31%. 2) ) The percentage score understanding of the concept in first cycle is 72,62%, second cycle is 90,18%, and the three cycle is 92,62%.
Pengembangan Model Pembelajaran Kepenyiaran Radio dengan Pemanfaatan Streaming Radio sebagai Upaya PembentukanLife SkillBagi Mahasiswa
Authors: Kusumaningsih Dewi 
Published: August 2018

This study examines the importance of developing learning model of radio broadcasting as a means of facilitating cognitive competencies and life skill for the students. The purposes of this study are (1) to describe the development of radio broadcasting learning model, (2) to prove that radio broadcasting learning can teach life skill the students. The method used is research and development (R D). The research is a preliminary study that includes (1) The field study on the learning model of radio broadcasting in PBSI Veteran Bangun Nusantara University lasted 2 years; (2) Stage description and analysis of findings; (3) Phase of drafting a learning model development and test radio broadcasting limited to science communication specialists. The data used are the Events Unit Class (SAP), the value of the fourth semester student at the college broadcasting PBSI, teaching faculty journals, and interviews. The results obtained are learning radio broadcasting fourth semester of academic year 2014/2015 was limited to conventional methods that rely lecture techniques and the use of textbooks. Students are invited to visit the study just outside the campus radio to simply look how the broadcaster broadcasts. Learning skills are not trained life skill which covers various techniques of designing a radio broadcast of the event, made a rundown of events, made hot clock radio broadcast, live events in studio practice until the practice of streaming radio.