bluuebunny/crossref_metadata_2025_split huggingface dataset:
flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
Authors: Wang Zhen-Yu , Mehra Armaan , Wang Qian-Chen , Gupta Savita , Ribeiro da Silva Agatha , Juan Thomas , Günther Stefan , Looso Mario , Detleffsen Jan , Stainier Didier Y. R. , Marín-Juez Rubén 
Published: November 2024

ABSTRACT
VEGFA administration has been explored as a pro-angiogenic therapy for cardiovascular diseases including heart failure for several years, but with little success. Here, we investigate a different approach to augment VEGFA bioavailability: by deleting the VEGFA decoy receptor VEGFR1 (also known as FLT1), one can achieve more physiological VEGFA concentrations. We find that after cryoinjury, zebrafish flt1 mutant hearts display enhanced coronary revascularization and endocardial expansion, increased cardiomyocyte dedifferentiation and proliferation, and decreased scarring. Suppressing Vegfa signaling in flt1 mutants abrogates these beneficial effects of flt1 deletion. Transcriptomic analyses of cryoinjured flt1 mutant hearts reveal enhanced endothelial MAPK/ERK signaling and downregulation of the transcription factor gene egr3. Using newly generated genetic tools, we observe egr3 upregulation in the regenerating endocardium, and find that Egr3 promotes myofibroblast differentiation. These data indicate that with enhanced Vegfa bioavailability, the endocardium limits myofibroblast differentiation via egr3 downregulation, thereby providing a more permissive microenvironment for cardiomyocyte replenishment after injury.
Noise suppression and image enhancement in cold atom absorption imaging
Authors: Zheng Pengcheng , Zhang Songqian , Ma Zhu , Niu Haipo , Wu Jiatao , Huang Zerui , Han Chengyin , Lu Bo , Liu Peiliang , Lee Chaohong 
Published: December 2024

The noise in absorption imaging of cold atoms significantly impacts measurement accuracy across a range of applications with ultracold atoms. It is crucial to adopt an approach that offers effective denoising capabilities without compromising the unique structure of atom clouds. Here, we introduce, to our knowledge, a novel image enhancement algorithm for cold atomic absorption imaging. The algorithm successfully suppresses background noise, enhancing image contrast significantly. Experimental results showcase that this approach can improve the image’s signal-to-noise ratio by about 10 dB and enhance the uncertainty of cold atom number measurements by approximately tenfold, preserving the spatial distribution of the atom clouds. Moreover, the method exhibits exceptional performance and robustness when confronted with fringe noise and multi-component imaging scenarios, offering high stability. Importantly, this method can perform denoising based on a single image (without the need to establish a reference library), and the optimization process is entirely automated, eliminating the need for manual parameter selection. The method is both compatible and practical, making it applicable to various cold atom absorption imaging fields.
Le dieu de Sénèque : Optimisme rationnel et pessimisme tragique - Indices
Authors: Merckel Cécile 
Published: November 2024

<p>Ce volume conclut à l’existence d’une théologie sénéquienne unifiée et faisant système, malgré la dualité des approches philosophique et littéraire qu’elle implique. Cette quête de définition du dieu stoïcien se réalise à travers une multiplicité de formes littéraires, qui sont autant de perspectives sur le divin. Les idées religieuses du philosophe offrent au progressant en sagesse une connaissance du dieu inductive et non déductive, expérimentale et non seulement théorique, sensible et non purement rationnelle – dans le cadre d’un monothéisme philosophique païen. Toute l’originalité de l’entreprise théologique de Sénèque réside donc paradoxalement dans un recentrage sur l’Homme, qu’il s’agit de délivrer de ses angoisses existentielles et de conduire à l’acceptation héroïque du plan divin. En effet, la théodicée mûrement pensée par Sénèque dépasse l’optimisme traditionnel du Portique – qui tient le dieu rationnel pour foncièrement provident – et affronte positivement la question de l’existence du Mal, qui culmine dans les tragédies. En définitive, le centre de gravité de la religion de Sénèque – fondée sur une exaltation de l’intériorité humaine – se déplace du dieu vers le sage, véritable héros parvenu à dépasser les vicissitudes de l’existence et dont la glorification constitue le degré suprême de piété. </p>
Nodal solutions for a zero-mass Chern-Simons-Schrödinger equation
Authors: Deng Yinbin , Liu Chenchen , Yang Xian 
Published: November 2024

Abstract
This study deals with the existence of nodal solutions for the following gauged nonlinear Schrödinger equation with zero mass:

−
Δ
u
+

h

u

2

(

∣
x
∣

)

∣
x
∣

2

+

∫

∣
x
∣

+
∞

h

u

(

s

)

s

u

2

(

s

)

d
s

u
=

∣
u
∣

p
−
2

u
,

x
∈

R

2

,

-\Delta u+\left(\frac{{h}_{u}^{2}\left(| x| )}{{| x| }^{2}}+\underset{| x| }{\overset{+\infty }{\int }}\frac{{h}_{u}\left(s)}{s}{u}^{2}\left(s){\rm{d}}s\right)u={| u| }^{p-2}u,\hspace{1.0em}x\in {{\mathbb{R}}}^{2},

where

p
>
6

p\gt 6

and

h

u

(

s

)

=

1

2

∫

0

s

r

u

2

(

r

)

d
r

{h}_{u}\left(s)=\frac{1}{2}{\int }_{0}^{s}r{u}^{2}\left(r){\rm{d}}r

. By variational methods, we prove that for any integer

k
≥
0

k\ge 0

, the above equation has a nodal solution

w

k

{w}_{k}

which changes sign exactly

k

k

times. Moreover, we also prove that

w

k

{w}_{k}

belongs to

L

2

(

R

2

)

{L}^{2}\left({{\mathbb{R}}}^{2})

provided

p
>
10

p\gt 10

.
Power of Terroir: Case study of Grašac at the Fruška Gora wine region (North Serbia)
Authors: Tomić Nemanja , Ninkov Jordana , Milić Stanko , Marković Slobodan B. , Tomić Tijana 
Published: December 2024

Abstract
The main goal of this study is to find out if there are any differences between Grašac wines from two different locations of the Fruška Gora Mountain and to further explore why these differences (if they exist) occur. To achieve this, we selected one vineyard in Sremski Karlovci and one in Neštin where we have analyzed the topography features, soil, and climate at both sites as well as the chemical analysis of the wines from these sites from three different vintages (2017–2019). Additionally, a sensory analysis was also done for seven consecutive vintages (2016–2022). The results reveal that the wines from Sremski Karlovci have a higher aroma intensity on the nose and dominant primary fruit aromas while they are young. These characteristics tend to drop quickly with age. On the other hand, Grašac wines from Neštin tend to age better, becoming fuller bodied, more intense, complex, with tertiary aromas on the nose and palate and with a longer finish. The key differences between these two locations are connected to the thick loess deposits and the amount of available water at the analyzed sites.
A socio-ecological approach to understanding self-regulation among adolescents with developmental challenges and delays
Authors: Paat Yok-Fong , Srinivasan Satish Mahadevan , Lin Mei-Ling 
Published: December 2024

Abstract
Drawing from the socio-ecological model, this study examined the relationships between child, family, and neighborhood/community factors and self-regulation among five subgroups of adolescents aged 12–17 years with developmental challenges and delays (Attention Deficit Disorder/Attention-Deficit/Hyperactivity Disorder, Autism/Autism Spectrum Disorder, developmental delay, learning disability, and intellectual disability). Data for this study came from the 2019 National Survey of Children’s Health, a nationally representative dataset (n=3,181). Using multiple regression analyses, we found that not all five subgroups of adolescents shared similar experiences. In sum, having good health and health insurance was positively associated with self-regulation, while adverse childhood experiences and being bullied were negatively linked to self-regulation. Family and neighborhood/community-related variables that were positively related to adolescents’ self-regulation consisted of parent-child closeness, having college-educated parents, household food security, and parents’ knowledge of where to obtain help in their neighborhood. Family variables negatively associated with adolescents’ self-regulation included living in two-parent households and receiving public assistance, but only for adolescents with intellectual disabilities. Socio-demographic variables significantly linked to adolescents’ self-regulation were biological sex, age, Hispanic ethnicity, and race. Future research and practice should focus on identifying and addressing the diverse ecological factors influencing adolescents’ social-emotional development to improve behavioral outcomes and support their transition to adulthood.
A Dangerous Metaphor: Thoughts on the Dysfunctionality of the Notion of a “Public-Private Divide”
Authors: Dowdle Michael W. 
Published: November 2024

Abstract
This article argues that the notion that state and religion should be strictly separated, resulting in a condition that is often captured by the metaphor of the “public-private divide,” is both unfounded and dangerous. It is unfounded in the sense that at least in modern functional democracies, the state and religion are not actually separated but are in fact constantly interacting and affecting one another. It is dangerous in the sense that if church and state could truly be separated, it would pose an existential threat to modern democratic-constitutional governance.
Excluding Women from Advertisements: Between Public and Private
Authors: Hostovsky Brandes Tamar , Tirosh Yofi 
Published: November 2024

Abstract
Advertisers in Israel routinely omit representation of women and girls as a form of adaptation to norms prevalent among ultra-Orthodox Jewish communities, by which the representation or allusion to a woman’s body, voice, or garments is considered immodest and distracting. What, if any, should be the response of antidiscrimination law to exclusionary advertisements, and why is this question worth exploring? This article argues that laws banning discrimination in the provision of products and services should also apply to advertisements that categorically refrain from presenting women. Beyond protecting individual members of vulnerable groups, antidiscrimination law should partake in freeing the public sphere of messages that reinforce discriminatory values. The intended, overt, and complete denial of women’s existence merits the law’s intervention in commercial speech. After conceptualizing the harm caused to unspecified individuals and defining discriminatory advertisements, we outline the considerations that should guide the designing of rules against discriminatory ads and apply them to a set of real-life incidents of exclusionary advertisements, demonstrating how to assess the severity of discrimination in each case. Finally, we consider the free speech implications, as well as the argument that liberal multicultural accommodation renders “modest” advertisements legitimate.
ЭГО-ДОКУМЕНТЫ В КОНТЕКСТЕ СОХРАНЕНИЯ И ИЗУЧЕНИЯ ИСТОРИКО-КУЛЬТУРНОГО НАСЛЕДИЯ
Authors: С.В. КОЗЛОВ 
Published: November 2024

В статье анализируется тенденция усиления внимания различных авторов к вопросам сохранения историко-культурного наследия, которое в европейских странах явилось значимым элементом национально-государственного строительства. Показано, как в связи с масштабными трансформациями, произошедшими в социогуманитарном знании в 1980-е гг., осуществляется становление нового междисциплинарного исследовательского направления heritage studies, занимающегося изучением наследия, в рамках которого сформировалось представление о наследии как о продукте, который создается и наделяется соответствующим символическим статусом заинтересованными в этом агентами в интересах воспроизводства разноуровневых идентичностей. Определено место, которое занимают в структуре наследия эго-документы как специфический вид источников, позволяющий вписывать индивидуальные биографии в общеисторический контекст. Отмечено, что, начиная с 1980-х гг., как в России, так и за рубежом наметилось существенное повышение внимания к публикации и изучению эго-документального наследия.
Currently, various state, municipal and public institutions show a steady interest in the issues of preserving historical and cultural heritage. The reason for this interest is related to the integral role that heritage plays in the reproduction of national, regional and local identity, which involves turning to a common past. The emergence of both the very concept of heritage and various practices of its preservation in Europe in the 19th century was closely associated with trends in national and state construction. In the 1980s, both the methods of preserving heritage and the sphere of heritage research undergo significant transformations. On the one hand, the number of agents involved in the processes of attributing symbolic status of heritage to certain artifacts is increasing, on the other hand, a new interdisciplinary scientific field of heritage studies is emerging, which has made heritage an object of study. The approaches developed in this area allow us to consider heritage as a result of endowing symbolic status to tangible and intangible objects, which are given the meaning necessary for the agents participating in this process. Ego-documents occupy a significant place in the structure of historical and cultural heritage as a specific type of source that allows individual biographies to fit into the general historical context and correlate individual testimonies with the official narrative that forms the national memory. Since the 1980s, in both Russia and abroad there has been a significant increase in attention to the publication and study of ego-documentary heritage. Various agents use the assignment of the symbolic status of elements of national, regional and local heritage to the documents of personal origin to reproduce multilevel identity. The intensification of these practices is also associated with the processes of digitizing an array of historical data with the involvement of various establishments and organizations.
Identidades y enseñanza de las ciencias sociales. Estudio de casos desde tres lugares del mundo.
Authors: Tosello Julia 
Published: December 2024

The construction of identities is of relevance for the teaching of democracy and social sciences (Santisteban y Pagés, 2007). With their imprint on action and anchoring in the future, identities are dynamic, narrative, historical, social, plural and permanent constructions, through which the world is interpreted and subjectivities are organized (Hall, 1996). From an interpretative and critical perspective, this paper aims to explore and analyze what the secondary curriculum of Social Sciences in Argentina, Catalonia and South Africa say about identities, and then, based on testimonies about the practice, establish some possible guidelines for potential proposals and curricular innovations on the subject. Through a mainly qualitative methodology (Eisner, 1990), the curriculums are approached through a document analysis (Rapley, 2014); the testimonies -corresponding to questionnaires and interviews made to some members of the professoriate of the three sites - are analyzed by emphasizing the perspectives on the practice by investigating and interpreting their meaning (Flick, 2015). Although in all three curriculums identities are assumed as social, historical and temporal constructions (Grossberg, 1996), in each case it occurs in a different way and with its own characteristics. A majority of teachers conceive identities as traits or characteristics of people and a minority thinks of them as constructions. Among the possible contributions for potential curricular innovations are emphasized in the identities as social constructions and in their relevance in the teaching of the social sciences.
Keywords
Identities; curriculum; social sciences; teaching; professorate
Evaluation of β-hCG regression after evacuation of molar pregnancy as a predictive factor for malignant GTN
Authors: Kader Mousumi , Elora Ashfi Laila , Chowdhury Mina , Afrose Taslima , Amin Rogina , Sultana Jolly Rabeya 
Published: November 2024

Background: Gestational trophoblastic disease (GTD) is a group of disorders identified by abnormal proliferation of trophoblastic tissue. The general term GTN is used to describe a wide range of trophoblastic diseases including invasive mole, choriocarcinoma, epithelioid trophoblastic tumor, and placental site trophoblastic tumor. The persistence of GTN post-molar pregnancy can be efficiently detected with serial measures of the β subunit of hCG, or β-hCG. Therefore, this study aimed to evaluate the β-hCG regression after evacuation of molar pregnancy as a predictive factor for malignant GTN.
Methods: This was a prospective analytical study conducted in the Gynaecological Oncology Unit and Department of Obstetrics and Gynecology, Dhaka Medical College Hospital, Dhaka, Bangladesh during the period from January 2022 to December 2022. In our study, we included 50 patients with molar pregnancies attending the Gynaecological Oncology Unit and Department of Obstetrics & Gynecology of DMCH.
Result: The mean age of participants was 23.5 years. The GTN was diagnosed among 24% of patients. In 2nd week, the mean β-hCG was found 91027.50±24430.53 miU/ml in the persistent GTN group and 19339.68±13978.59 miU/ml in the remission group. The mean Β-hCG significantly decreased to 64399.33±23404.81 and 4.47±2.57miU/ml in the persistent GTN and remission group respectively in the 15th week (p<0.05).
Conclusion: This study found that serum β-hCG levels in the 2nd, 3rd, and 4th weeks following molar evacuation can predict over 24% of patients who developed GTN after molar evacuation. The decline in serum β-hCG levels during weeks was statistically linked to the development of GTN.
Is Tamil consonant “G\" A misleading factor? - A pilot study
Authors: Maran Keerthi Priya , Karuppiah Prabhu 
Published: December 2024

The article emphasizes the importance of acknowledging linguistic diversity in palatographic evaluations within clinical settings. It highlights the distinct phonetic variations of the "G" consonant in the Tamil language compared to English, demonstrating the necessity for customized assessment tools and phonetic indexes to accurately evaluate and accommodate these differences.To examine the influence of Tamil phonetics on the fabrication of complete dentures and to use palatogram as a method for evaluating the phonetic impact on complete denture fabrication in Tamil-speaking patients. The study involved ten completely edentulous denture wearers. These dentures were fabricated and assessed for phonetic influences using specific Tamil phonetic sounds: SH, N, CH, K, and G. The primary focus of this article is on the phonetic sound "G," evaluated using the word "Jeevan." The phonetic evaluation was conducted through the palatogram method.The study demonstrated that the palatograms from all edentulous patients showed significant variations in their palatographic patterns. These patterns tended to be more palatolingual differing from the velar palatographic pattern observed with the English consonant "G." The study emphasizes that relying exclusively on English norms may not adequately capture the intricacies present in other languages. Therefore, the development of specific palatographic indices for each language is essential for precise evaluations and meeting the requirements of diverse patient populations. This approach aligns with healthcare principles of linguistic and cultural competence, ultimately enhancing diagnostic accuracy and treatment effectiveness.
Effect of different scan patterns on accuracy of angulated and straight implant- An in vitro study
Authors: Diwase Harshal Ghanashyam , Gholap Aishwarya Diliprao , Mahale Kishor , Khalikar Smita Arun , Rajguru Vilas , Mahajan Sonali , Tandle Ulhas 
Published: December 2024

: A recently introduced scan body enables digital scan of implant, giving its perfect position .However, information on the effect of different scan pattern on scan accuracy of digital implant, scan of angulated and parallel implant is lacking.The purpose of this In -Vitro study was to evaluate effect of different scan pattern on scan accuracy of digital implant scan of angulated and parallel implant to adjacent tooth.Two models were generated secured with lab analog ,one parallel to adjacent tooth and one angulated (between 15 to 18degree) to the adjacent teeth at right second molar region in dentate mandibular model .The master reference model was generated by scanning the model with lab scanner.The models were then scanned with 4 different scan pattern(SP-A,SP-B,SP-C,SP-D) by using intra oral scanner ( Densply Sirona cerec Omnican). STL file was generated for both (control and study group) and by using Autodesk mesh mixer software measurements were made for accuracy.Results were analyzed using One way anova test. No statistical significant difference found between scan patterns in both parallel and angled implant but there was different in the mean deviation in both the models among different scan pattern. In both the models, scan pattern A was found more accurate compared to other scan patterns.The scan pattern influenced by accuracy of intra oral scanner in different ways. n terms of both trueness and precision SP-A is found most accurate and SP-D least has least accuracy. Hence full arch scanning will give more accurate results rather than sectional scanning.
Prosthetic management in mayer-rokitansky-küster-hauser (MRKH) Syndrome: A case report highlighting vaginal reconstruction and its impact on quality of life
Authors: Selvam Divyabharathi , Balaji Hemamalini , Mohamed K Kasim 
Published: December 2024

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a congenital condition affecting 1 in 4,500 female births, is marked by the absence or underdevelopment of the uterus and upper vagina. Vaginal reconstruction is vital for sexual function, with prosthetic stents playing a key role in maintaining neovaginal patency.Femal patient with MRKH syndrome were treated using custom-made hollow vaginal stents following the Abbe-McIndoe technique. Stents were fabricated from heat-cure acrylic resin based on MRI measurements, ensuring optimal fit and function. Follow-up confirmed maintained vaginal patency. This case report highlights the critical role of prosthodontists in managing MRKH syndrome. Custom prosthetic stent provided excellent outcomes, though challenges with retention and patient compliance was noted, underscoring the need for continued innovation. Personalized prosthetic vaginal stents are effective in managing MRKH syndrome, improving patient quality of life. These findings support their use as a standard treatment option.