bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women
Authors: Ding Guan-Jun , Jiang Wei , Lyu Jie-Qiong , Ma Jie , Chen Guo-Chong , Li Fu-Rong , Yang Si-Jia , Miao Meng-Yuan , Hua Yong-Fei 
Published: November 2024

BackgroundWomen are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis of gallbladder disease. This study aimed to assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term risk of cholecystectomy in women.MethodsA total of 184,677 women were included from the UK Biobank. Multivariable Cox regression models were used to estimate the associations of menopausal characteristics and HRT with risk of cholecystectomy. The joint influence of HRT use and the status and type of menopause on incident cholecystectomy were further evaluated.ResultsDuring a median of 12.7 years of follow-up, 4,991 incident cases of cholecystectomy were identified. Natural menopause, regardless of menopausal age, was not associated with risk of cholecystectomy, while surgical menopause at a young age was associated with a higher risk of cholecystectomy. Ever use of HRT was associated with a higher risk of cholecystectomy. In particular, women who were surgically-menopausal and started HRT before menopause had the highest risk for cholecystectomy (hazard ratio = 2.28; 95% confidence interval: 1.70–3.04), when compared with women who were naturally-menopausal and never used HRT.ConclusionsEarly surgical menopause and ever use of HRT was independently associated with the risk of cholecystectomy.
Research trends and hotspots on septic shock: a bibliometric study and visualization analysis
Authors: Wang Sitong , Li Nan , Ma Ben , Zhu Shuang , Zhou Yu , Ma Ruihang 
Published: November 2024

BackgroundSeptic shock, the most severe stage of sepsis, causes potential circulatory failure and abnormal cell metabolism which are severe enough to affect prognosis, increase mortality, and impose significant burdens on the medical system. Despite a growing number of studies exploring the pathophysiology, epidemiology, and risk factors, research trends and hotspots in septic shock remain lacking. This study aims to create a visual knowledge map, identify research hotspots, and predict prospective trends based on bibliometric analysis.MethodsWe searched for publications related to septic shock in Web of Science Core Collection up to June 15, 2023. CiteSpace5.5 R2, VOS viewer and Pathfinder were used to evaluate the annual publications, countries, institutions, journals and keywords. We also analyzed the collaboration among countries, institutions and authors, and identified research hotspots and frontiers.ResultsA total of 4,208 English papers were included in the analysis, and the annual publication displayed a slow upward trend. In terms of publication volume, the top three countries were the United States, France, and Germany, and the University of Pittsburgh (the United States) ranked first (n = 85) among all institutions, with Jeanlouis Vincent from Erasmus Medical Center (Netherlands) as the most published author (n = 32). According to the collaborative network, the United States had the highest level of cooperation, and the University of Pittsburgh, the University of Toronto, and Columbia University were the institutions with the most foreign cooperation. Additionally, the co-author network revealed that scholars such as Jeanlouis Vincent, Rinaldo Bellomo, and Djillali Annane, had the strongest collaborations. The co-citation network showed that the top 3 most cited articles were: Singer M (2016), Rhodes A (2017), Dellinger RP (2013), and the top 3 most cited journals were Crit Care Med (3,664 times), N Engl J Med (3,207 times), Intens Care Med (3,096 times) in this field. In the keyword co-occurrence network, the most frequent keywords were “septic shock” (2531), “sepsis” (1667), and “mortality” (569), indicating the current research hotspots. Pathobiology, fluid therapy, and endotoxic septic shock were emerging trends in research.ConclusionBy using bibliometrics, this study reviewed the studies in septic shock and revealed the hotspots and cutting-edge trends, including the pathogenesis of complications, the development of new biomarkers, the timing and methods of alternative treatments, and the rehabilitation trajectory, etc., which provided a reference for subsequent studies in septic shock.
Gut microbiota dysbiosis in patients with Alzheimer’s disease and correlation with multiple cognitive domains
Authors: Chen Qionglei , Shi Jiayu , Yu Gaojie , Xie Huijia , Yu Shicheng , Xu Jin , Liu Jiaming , Sun Jing 
Published: November 2024

BackgroundAccumulating evidence suggested that Alzheimer’s disease (AD) was associated with altered gut microbiota. However, the relationships between gut microbiota and specific cognitive domains of AD patients have yet been fully elucidated. The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.MethodsA total of 64 subjects (18 mild AD, 23 severe AD and 23 healthy control) were recruited in the study. 16 s rDNA sequencing was performed for the gut bacteria composition, followed by liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) analysis of short-chain fatty acids (SCFAs). The global cognition, specific cognitive domains (abstraction, orientation, attention, language, etc.) and severity of cognitive impairment, were evaluated by Montreal Cognitive Assessment (MoCA) scores. We further identified characteristic bacteria and SCFAs, and receiver operating characteristic (ROC) curve was used to determine the predictive value.ResultsOur results showed that the microbiota dysbiosis index was significantly higher in the severe and mild AD patients compared to the healthy control (HC). Linear discriminant analysis (LDA) showed that 12 families and 17 genera were identified as key microbiota among three groups. The abundance of Butyricicoccus was positively associated with abstraction, and the abundance of Lachnospiraceae_UCG-004 was positively associated with attention, language, orientation in AD patients. Moreover, the levels of isobutyric acid and isovaleric acid were both significantly negatively correlated with abstraction, and level of propanoic acid was significantly positively associated with the attention. In addition, ROC models based on the characteristic bacteria Lactobacillus, Butyricicoccus and Lachnospiraceae_UCG-004 could effectively distinguished between low and high orientation in AD patients (area under curve is 0.891), and Butyricicoccus and Agathobacter or the combination of SCFAs could distinguish abstraction in AD patients (area under curve is 0.797 and 0.839 respectively).ConclusionThese findings revealed the signatures gut bacteria and metabolite SCFAs of AD patients and demonstrated the correlations between theses characteristic bacteria and SCFAs and specific cognitive domains, highlighting their potential value in early detection, monitoring, and intervention strategies for AD patients.
The association between patients’ personality traits and pain perception during orthodontic treatment: a systematic review
Authors: Lorek Monika , Jarząbek Anna , Sycińska-Dziarnowska Magdalena , Gołąb Sylwia , Krawczyk Konrad , Spagnuolo Gianrico , Woźniak Krzysztof , Szyszka-Sommerfeld Liliana 
Published: November 2024

BackgroundOrthodontic treatment is frequently correlated with different levels of discomfort and pain, caused by the application of forces to move the teeth. The mechanism of orthodontic pain is based on the initially activation of sensory receptors in periodontal tissues which results in a cascade of nociceptive pain processing and transduction in both the central and peripheral nervous systems that is finally experienced by patients. The perception of pain is subjective and varies among people, as it is influenced by both general and individual elements. This systematic review aims to synthesize existing knowledge on the association between patients’ personality traits and pain perception during orthodontic treatment, and its influence on the success of orthodontic therapy.MethodsThe search strategy included the databases PubMed, Scopus, Embase, and Web of Science. The inclusion criteria were studies examining the correlation between personality traits and pain perception in patients undergoing orthodontic treatment. The quality of the studies was assessed using the Newcastle–Ottawa Scale (NOS).ResultsThe search strategy yielded 301 potential articles, with 10 papers meeting the inclusion criteria. Five studies were judged at a low risk of bias and another five studies were assessed as having a moderate risk of bias. Most of the studies reported relationship between personality traits and pain perception during orthodontic treatment, as well as treatment attitudes, and post-treatment satisfaction.ConclusionPatients’ psychological characteristics seems to affect pain perception and other factors associated with orthodontic treatment. Given that several studies were judged to have a moderate risk of bias, as well as high heterogeneity among studies, further research is needed.Systematic review registrationThe systematic review was registered in PROSPERO database (CRD42024537185).
Immunohistochemical basis for FAP as a candidate theranostic target across a broad range of cholangiocarcinoma subtypes
Authors: Jorgenson Laura C. , Torbenson Michael S. , Halfdanarson Thorvardur R. , Kankeu Fonkoua Lionel A. , Tran Nguyen H. , Roberts Lewis R. , Smoot Rory L. , Goenka Ajit H. , Thompson Scott M. 
Published: November 2024

PurposeThe aims of this study were to evaluate and compare fibroblast activation protein (FAP) expression and localization in surgically resected cholangiocarcinoma (CCA), primary and metastatic hepatocellular carcinoma (HCC), hepatocellular adenoma (HCA), and focal nodular hyperplasia (FNH), and to identify any association between CCA clinical or pathologic features and FAP expression.Materials and methodsFAP immunostaining from surgically resected CCA (N = 58), primary intrahepatic and extrahepatic metastatic HCC (N = 148), HCA (N26), and FNH (N = 19) was scored (negative, weak positive, moderate positive or strong positive) from tissue microarrays. FAP expression was compared between groups. CCA FAP expression was compared to clinical and tumor pathology features.ResultsModerate-strong FAP expression in the tumor stroma was present in 93.1% of CCA, 60.7% of extrahepatic metastatic HCC, 29.6% of primary HCC, 21.1% of FNH, and 11.6% of HCA. Moderate-strong FAP expression in tumor stroma was significantly more prevalent in CCA than HCC (p &lt; 0.001), metastatic HCC (p = 0.005), HCA (p &lt; 0.001) and FNH (p &lt; 0.001). FAP was expressed in the stroma of all but one CCA (1.7%), and FAP expression in CCA tumor stroma was not associated with any clinical or tumor pathology features (p &gt; 0.05, all).ConclusionFAP is expressed in the stroma of a high proportion (93%) of primary CCA independent of patient clinical or tumor pathology features. As such, these data provide the tissue basis for systematically evaluating FAP as a theranostic target across a broad range of CCA subtypes.
Ubiquitin-specific peptidases in lymphoma: a path to novel therapeutics
Authors: Samareh Salavatipour Maryam , Tavakoli Shirin , Halimi Aram , Tavoosi Shima , Baghsheikhi Amir-Hossein , Talebi-Taheri Abdolkarim , Niloufari Mehdi , Salehi Zahra , Verdi Javad , Rahgozar Soheila , Mosavi-Jarrahi Alireza , Ahmadvand Mohammad 
Published: November 2024

BackgroundUbiquitin-specific peptidases (USPs), also known as deubiquitinating enzymes (DUBs), play a crucial role in maintaining cellular homeostasis by selectively removing ubiquitin molecules from targeted proteins. This process affects protein stability, subcellular localization, and activity, thereby influencing processes such as DNA repair, cell cycle regulation, and apoptosis. Abnormal USP activities have been linked to various diseases, including cancer. Emerging evidence in lymphoma studies highlights the significance of USPs in controlling signaling pathways related to cancer initiation and progression and presents them as potential therapeutic targets.AimThis study aimed to elucidate the multifaceted roles of USPs in lymphoma.MethodsThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles published in English up to May 2023 were retrieved from PubMed, Web of Science, and Scopus. The inclusion criteria focused on studies investigating the role of USPs in lymphoma cancer, involving human subjects or relevant lymphoma cell lines, exploring molecular mechanisms and signaling pathways, and assessing diagnostic or prognostic value.ResultsAfter the selection process, 23 studies were selected for analysis. USPs were found to affect various aspects of lymphoma development and progression. Specific USPs were identified with roles in cell-cycle regulation, apoptosis modulation, drug resistance, DNA repair, and influence of key oncogenic pathways, such as B cell receptor (BCR) signaling.ConclusionThis systematic review underscores the emerging role of USPs in lymphoma and their potential as therapeutic targets. Inhibitors of USPs, such as USP14 inhibitors, show promise in overcoming drug resistance. The dynamic interplay between USPs and lymphoma biology presents an exciting opportunity for future research and the development of more effective treatments for patients with lymphoma. Understanding the intricate functions of USPs in lymphoma offers new insights into potential therapeutic strategies, emphasizing the significance of these enzymes in the context of cancer biology.
Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome
Authors: Ma Xieli , Liu Zixia , Chang Tian , Yao Chuanhui , Yang Yuchen , Shang Biyue , Liu Jiameng , Xia Congmin , Gong Xun , Jiang Quan 
Published: November 2024

ObjectiveTo evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren’s syndrome (SS).MethodsCNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine (CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation. Analyses were performed using Review Manager (version 5.4) and R-4.3.1.ResultsA total of 66 RCTs were included, with a sample size of 5,052, involving four kinds of TCM (total glucosides of paeony capsules, tripterygium glycosides tablet, Xinfeng capsule and Jinju Qingrun capsule) and three kinds of CWM(hydroxychloroquine sulfate, Iguratimod and glucocorticoid). The network meta-analysis results showed that IGU + HCQ + TGP ranked the highest in reducing ESR and IgG and improving the Schirmer test when the three drugs were combined. When the two drugs are combined, IGU + GC and TGT + TGP are good choices for reducing erythrocyte sedimentation rate (ESR) and Immunoglobulin G (IgG). Although TGP + HCQ vs. HCQ had the most studies, TGP combined with HCQ did not rank high in each outcome indicator. It is recommended to use TGT and XFG in decreasing ESR and IgG for a single drug. JJQR have an advantageous role in relieving xerostomia and dry eyes.ConclusionTCM combined with CWM has a very significant effect on treating SS compared with CWM alone. According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42023451845].
Unveiling the therapeutic role of Dachaihu decoction in acute cholecystitis: a comprehensive systematic review and meta-analysis of its efficacy and safety
Authors: Liu Xin-xin , Ma Ying-qi , Kong Ling-yao , Su You-zhu , Robinson Nicola , Liu Jian-ping 
Published: November 2024

BackgroundDachaihu decoction (Dachaihu tang) plays a crucial role in treating acute illnesses. Recently, a significant number of clinical studies on Dachaihu decoction for acute cholecystitis (AC) have been published. This study was conducted to assess the efficacy and safety of Dachaihu decoction in patients with this condition.MethodsTo identify relevant randomized controlled trials (RCTs), eight databases and three clinical trial registries were searched from inception to 30 June 2024. Two researchers independently screened and extracted data from eligible studies using EndNote X9 and Microsoft Office Excel 2019. RoB 2.0 was used to assess the risk of bias in the included studies. Stata 17.0 was used for data analysis. Publication bias and its impact on result stability were evaluated using a funnel plot and the “trim-and-fill” method. The quality of evidence was graded using the GRADE assessment system.ResultsThirty-three RCTs involving 2,851 participants were included. The treatment group demonstrated improved clinical efficacy (RR = 1.18; 95% CI = 1.13 to 1.24), significantly reduced length of hospital stay (MD = −1.78 days; 95% CI = –2.02 to −1.53), and the incidence of adverse events (RR = 0.31; 95% CI = 0.20 to 0.48). Additionally, there appeared to be reductions in the time for abdominal pain to resolve (MD = −1.92 days; 95% CI = –2.33 to −1.51), fever to disappear (MD = −1.52 days; 95% CI = –1.90 to −1.14), white blood cell count to return to normal (MD = −2.89 days; 95% CI = –3.32 to −2.46), alanine aminotransferase (ALT) levels (MD = −11.88 U/L; 95% CI = –15.29 to −8.47), aspartate aminotransferase (AST) levels (MD = −8.74 U/L; 95% CI = –9.76 to −7.72), neutrophil percentage (MD = −9.68; 95% CI = –11.33 to −8.03), TNF-α levels (SMD = −2.10 pg/L; 95% CI = –2.43 to −2.78), and certainty of evidence (moderate-to-low certainty).ConclusionDachaihu decoction may be an effective botanical formula for managing AC and a lower incidence of adverse events. However, due to the substantial risk of bias and heterogeneity across the included studies, these findings should be interpreted with caution and require further validation through well-designed, high-quality trials.Systematic Review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=573332.
Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report
Authors: Jia Yanxi , Zhan Yongchi , Huang Guiqiong , Deng Chunyan , Yu Haiyan 
Published: November 2024

IntroductionBrodifacoum is a highly potent superwarfarin rodenticide that leads to coagulopathy. Although the effect of warfarin during pregnancy is well understood, reports on superwarfarin poisoning, like brodifacoum, during pregnancy are scarce.Case PresentationWe report a case involving a woman with a singleton pregnancy who experienced sudden nasal hemorrhage accompanied by hematuria at 34 weeks and 3 days of gestation, with no apparent etiology. It was ultimately diagnosed as acquired coagulopathy resulting from brodifacoum poisoning. Fetal ultrasonography revealed significant intracranial hemorrhage, leading to intrauterine fetal demise and subsequent pregnancy termination. Following the correction of the patient’s coagulation profile through intravenous and oral administration of vitamin K1, tailored to the serum levels of brodifacoum, diligent monitoring confirmed that the patient was in stable condition.ConclusionThe primary hazard associated with the ingestion of brodifacoum is hemorrhage, with clinical presentations varying from asymptomatic cases to overt bleeding, which may present as hematuria, epistaxis, menometrorrhagia, and intracranial hemorrhage. Therefore, the diagnosis and management of this type of poisoning pose significant challenges. Prompt recognition and ongoing care for pregnant individuals affected by rodenticide toxicity are crucial for optimizing maternal health outcomes.
Enduring effects of psychotherapy, antidepressants and their combination for depression: a systematic review and meta-analysis
Authors: Voderholzer Ulrich , Barton Barbara B. , Favreau Matthias , Zisler Eva M. , Rief Winfried , Wilhelm Marcel , Schramm Elisabeth 
Published: November 2024

IntroductionAlthough depressive disorders are frequently associated with relapses, the sustained efficacy of therapies after their termination has been insufficiently investigated.ObjectiveThe aim of this study was to evaluate the current evidence of enduring effects of psychotherapy, antidepressants and their combination after the end of treatment.MethodsPubMed and PsychINFO were systematically screened according to PRISMA guidelines (except for preregistration). Only randomized controlled trials (RCTs) between 1980 and 2022 comparing the efficacy of psychotherapy, antidepressants and their combination in adult depression at follow-up at least 12 months after termination of therapy, which could be acute phase, maintenance or relapse prevention therapy, were included. Risk of bias was assessed by using the Cochrane risk of bias tool.ResultsIn total 19 RCTs with a total of 1154 participants were included. Psychotherapy was significantly superior to pharmacotherapy regarding relapse rates and Beck Depression Inventory scores at follow-up after acute treatment in two of nine RCTs. Combined treatment performed significantly better than pharmacotherapy, but not psychotherapy, regarding relapse and remission in five out of nine RCTs at least 12 months after treatment termination. Pairwise meta-analyses indicated a superiority of combined treatment compared to pharmacotherapy alone regarding relapse, recurrence, and rehospitalization rates (RR=0.60, 95%-CI: 0.37-0.97, p=.041) and for psychotherapy compared to pharmacotherapy alone regarding relapse and recurrence rates (RR=0.58, 95%-CI: 0.38-0.89, p=.023), however comparative treatment effects between psychotherapy and combined treatment were insignificant.ConclusionsCurrent findings suggest a superiority of psychotherapy and combined treatment over pharmacotherapy alone in major depressive disorder depression. Major limitations were a low number of studies reporting follow-up data after termination of study periods and a heterogeneity in definitions of treatment outcomes. Practice guidelines and participatory decision-making processes for the choice of treatment should consider the current knowledge on long-term effects of antidepressant therapy methods more than has been the case to date.