bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation
Authors: Wen Jie , Zhao Lingmao , Li Zhuohan , Pi Chao , Feng Xianhu , Shi Peng , Yang Hongru , Chen Ligang , Wang Xiaodong , Liu Furong , Wei Yumeng , Zhao Ling 
Published: November 2024

Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthesized, and evaluated in the present study. Among them, CA8 exhibited the highest water solubility, which was approximately 2.37 × 106 times that of CU. In addition, compared with CU, its cytotoxicity on Caco-2 cells (19.2 times/48 h) was stronger. Of note, CA8 arrestedthe cell cycle of Caco-2 cells at the G2/M phase and induced apoptosis. Meanwhile, acute toxicity experiments indicated that KM mice tolerated CA8 for up to 300 mg/kg CA8 (oral administration) and 50 mg/kg CA8 (intraperitoneal injection). The oral administration of CA8 to Sprague Dawley rats exhibited higher AUC (0-t) (6.23-fold) and longer MRT (0-t) (3.35-fold) than that of CU. CA8 also inhibited the proliferation and angiogenesis of tumor cells more than CU and tegafur. Finally, CA8 may exert anti-tumor effects through the activation of JNK pathway and inhibition of AKT pathway. These results suggest that CA8 is a safe and highly effective new drug for colon cancer treatment.
Effects of loneliness on short video addiction among college students: the chain mediating role of social support and physical activity
Authors: Zhao Zhe , Kou Yali 
Published: November 2024

Loneliness is a common public health problem that affects physical and mental health. Prior research has demonstrated a connection between internet addiction and loneliness. Short video addiction is a novel internet addiction. It is necessary to study the potential psychological mechanisms between loneliness and short video addiction. This study investigated the associations between loneliness and short video addiction, as well as the mediating roles played by social support and physical activity.MethodsA sample of 388 college students was selected, and the questionnaires included the Loneliness Scale Short Version, the Short Video Addiction Scale, the Social Support Scale, and the Physical Activity Scale. The data were analyzed using SPSS for correlation analysis and PROCESS macros for mediation effect analysis.Results(1) Loneliness significantly positively affected short video addiction. (2) The association between loneliness and short video addiction was independently mediated by social support. (3) Physical activity independently mediated loneliness and short video addiction. (4) Social support and physical activity play a chain mediating role in the association between loneliness and short video addiction. Our research improves the literature on loneliness and short video addiction, enhances comprehension of the impacts, and offers college students effective ways to combat the addiction.
Persistent elevation of plasma markers of cellular senescence after hip fracture: a pilot longitudinal study
Authors: Lenze Eric J. , Nicol Ginger E. , Kuchel George A. , Avidan Michael S. , Diniz Breno S. 
Published: November 2024

IntroductionHip fractures may result from and contribute to accelerated biological aging. We aimed to evaluate the impact of hip fracture and its surgery on the senescence-associated secretory phenotype (SASP) index, a composite of peripheral protein markers where higher scores are thought to indicate greater levels of cellular senescence and accelerated aging.MethodsWe examined the SASP index in plasma over 12 weeks post-surgery and its prediction of long-term post-surgical functional outcomes. We included 60 older adults: 20 recruited immediately after hip fracture surgery, and 40 comparison individuals who were either healthy or suffering chronic psychosocial stress (caregiving). We assessed 22 SASP biomarkers and calculated the SASP index score for each hip fracture participant immediately following fracture surgery and 4 and 12 weeks later. Functional recovery was assessed at 12, 26, and 52 weeks after hip replacement surgery.ResultsThe hip fracture group had higher SASP index scores than the comparison groups, after adjusting for potential confounding variables (p = 0.021). SASP index scores in hip fracture patients increased further by week 4 after surgery (p &lt; 0.001), declining by week 12 but remaining elevated overall. However, the SASP index scores were not significantly associated with functional recovery after hip replacement surgery at 26 or 52 weeks after surgery. In conclusion, after hip fracture surgery SASP scores are elevated, continue to rise over time, and do not return to normal by 12 weeks post-surgery.DiscussionOur findings support the need to investigate this phenomenon of post-operative senescence, including whether novel interventions such as senolytics would help older adults facing major surgery.
Theories of change: navigating diverse expert perceptions and preferences for global food system transformation
Authors: Loring Philip A. , Loken Brent , Bhalla Iqbal S. , Daniel Adil , De La Torre Ana , Friedman Suzy , Melo-Rijk Melody , del Rosario Liezl Stuart , Tardiou Ariane , van Dooren Corné , Upadhyay Gargi 
Published: November 2024

IntroductionEfforts are underway to transform food systems in light of their contributions to global challenges like climate change. However, food systems are highly complex, involve noteworthy place-based challenges, and there is often debate and disagreement among experts over appropriate technologies or interventions to prioritize. Tracking progress, and understanding these differences, is thus a critical need.MethodsWe surveyed food systems experts in eight countries about their preferences for 20 different food system transformation strategies and their sentiment regarding whether current initiatives are sufficient to meet 2030 goals for climate and biodiversity.ResultsExpert sentiment is overwhelmingly negative, and experts are concerned about multiple “transformation gaps,” including gaps in ambition, strategy, and implementation. Expert rankings for 20 strategies vary notably among countries and in ways that do not match those same experts’ rankings for the strength of the science behind each lever. Factor analysis reveals four distinct theories of change informing experts’ subjective biases: transformation via technical optimization, via smallholder support, via nature-positive solutions, and via supply chain enabling conditions.DiscussionThese findings provide insights for navigating the complexities of food system transformation and illustrate the influence on our strategies of preconceptions and biases in how we have come to understand the nature of the challenge.
Fisiopatologia da gastrite e correlação com H. pylori: uma investigação profunda e suas implicações clínicas
Authors: Duarte Ana Carolinne Guerreiro , Zhao Bruna Wu , Lemos Clarissa de Deus , Santos Kézia Signer , Araújo Lanna Samara de Carvalho , Pascoal Millena Lima , Lemos Yasmin de Deus , Silva Patricia Alves 
Published: November 2024

A gastrite é uma inflamação da mucosa gástrica que pode ser desencadeada por diversos fatores, tais como o uso prolongado de alguns medicamentos, o tabagismo, e a infecção pela bactéria Helicobacter pylori (HP). A prevalência dessa infecção engloba, aproximadamente, metade da população mundial, e, embora a relação dessa com a gastrite não se encontrar completamente elucidada, sabe-se que a virulência bacteriana, o sistema imunológico do hospedeiro e as influências ambientais interagem a constituir um mecanismo complexo que estabelece diferentes fenótipos da gastrite. Esses diferentes fenótipos podem distinguir-se em cronicidade, gravidade, diagnóstico tardio, resposta ou refratariedade ao tratamento, e complicações clínicas. Esta revisão de literatura visa explorar a fisiopatologia da gastrite associada a Helicobacter pylori e suas implicações clínicas, a fim de fornecer uma compreensão abrangente dessa condição e suas implicações para a prática médica, abordando sua associação com úlceras pépticas, câncer gástrico e anemia, além de revisar opções terapêuticas disponíveis contra esta infecção. Para tanto, foram identificados 154 artigos e, destes, foram selecionados 18 para este estudo com base nos critérios de inclusão e de exclusão adotados. Desse modo, observou-se a ação potencializadora da H. pylori no desenvolvimento de algumas doenças gastroenterológicas, como constatado no aumento da expressão genética de PREX2, encontrado em células cancerosas e nos achados endoscópicos de nodularidade antral, ambos em decorrência desta bactéria, o que permite concluir a estreita relação da gastrite com implicações clínicas de intensa gravidade e a longo prazo.
Antioxidant activity and content of total phenols and flavonoids of aqueous extracts from leaves of Pistacia lentiscus L.
Authors: Walid Benchiha , Ahmed Aouadj Sid , Ahmed Megharbi , Asma Tamert , Khaoula Lazreg , Houda Lazreug Nour El , Atika Belkhadem 
Published: November 2024

The Mounts of Tessala (western of Algeria) is a remarkable site of plants diversity, characterized by the presence of numerous aromatic and medicinal species used by the local population as therapeutic agents, the mastic tree (Pistacia lentiscus L.) is among the plants inhabiting this mountain; it is a perennial shrub belonging to the family Anacardiaceae.
The dosage of some polyphenols (total phenols, flavonoids) varied respectively between 21.20 - 98.23 mg gallic acid equivalents/g and 39.767 - 91.288 mg catechin equivalents/g. ANOVA revealed a significant variation in the mean concentrations according to the used extract.
Evaluation of the antioxidant power of aqueous extracts has revealed a remarkable biological effect. The high inhibition percentages (100%) were found in the decocted extract at 10 mg/mL, followed by the macerated extract at 10 mg/mL, and finally the infused extract with 82.99% at 20 mg/mL. The DPPH free radical scavenging test revealed that the antioxidant activity of aqueous extracts varied significantly according to extract type and its concentration.
The results obtained not only confirm the richness of active principles in the studied plant but also its therapeutic effectiveness.
No Experience Required: Inclusive Undergraduate Research in Computational Biophysical Chemistry
Authors: Theisen Kelly E. 
Published: November 2024

ABSTRACT
Undergraduate research is a key tool for recruitment and, more importantly, retention of science, technology, engineering, and math students. Unfortunately, many students are not aware of or do not take advantage of these opportunities and, at best, often wait until late in their college careers. For my undergraduate computational biophysical chemistry research lab I have established a no-experience-required policy that allows me to recruit and mentor more research students. It also allows me to be more inclusive and expand the pool of students who have access to research. This also results in a more diverse research group, which is particularly important at a primarily undergraduate institution that has a diverse population with a high percentage of first-generation students. Here, I lay out the procedures I use to recruit and train students of all levels for my research lab, as well as the research products produced by students and myself.
Hubungan Lama Menyandang Diabetes Melitus dengan Kualitas Hidup Pasien Klub Prolanis Maleosan Tomohon
Authors: Tombokan Vera D. , Salibana Hengki E. 
Published: November 2024

Abstract: Data of the 2018 Riset Kesehatan Dasar (Riskesdas) showed that North Sulawesi was ranked 4th in the highest prevalence of diabetes mellitus. In Tomohon City, cases of diabetes mellitus also increase continually from year to year and are one of the five most common metabolic diseases. Prolanis (chronic disease control program) is expected to be a forum to improve health and quality of life of patients with chronic diseases such as diabetes mellitus. This study aimed to determine the relationship between the length of time suffering from diabetes and the quality of life of Prolanis Maleosan Club patients in Tomohon. This was a correlation and analytical study. Samples were 45 prolanis patients of Maleosan club. Data were collected using the WHOQOL-BREF questionnaire and were analyzed using the chi-square test. The results showed that there was no relationship between the length of time suffering from diabetes mellitus and the quality of life of Prolanis patients with a p-value of 0.322. In conclusion, there is no relationship between the length of time suffering from diabetes mellitus and the quality of life among patients of Prolanis Maleosan Club in Tomohon.
Keywords: diabetes mellitus; length of suffering; quality of life

Abstrak: Data Riskesdas 2018 menunjukkan bahwa Sulawesi Utara menempati peringkat ke 4 angka prevalensi diabetes melitus tertinggi. Di Kota Tomohon kasus diabetes melitus juga terus mengalami peningkatan dari tahun ke tahun dan merupakan 1 dari 5 penyakit metabolik terbanyak. Prolanis diharapkan dapat menjadi wadah untuk meningkatkan derajat kesehatan dan kualitas hidup pasien penyakit kronis seperti diabetes melitus. Penelitian ini bertujuan untuk mengetahui hubungan antara lama menyandang diabetes dengan kualitas hidup pasien prolanis klub Maleosan Tomohon. Jenis penelitian ialah analitik korelasi dengan sampel 45 pasien. Pengambilan data menggunakan kuesioner WHOQOL- BREF dan data dianalisis menggunakan menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa tidak terdapat hubungan antara lama menyandang diabetes dengan kualitas hidup pasien dengan nilai p= 0,322. Simpulan penelitian ini ialah tidak terdapat hubungan antara lama menyandang diabetes melitus dengan kualitas hidup pasien prolanis Maleosan Tomohon.
Kata kunci: diabetes melitus; lama menyandang; kualitas hidup
Edukasi Pertolongan Pertama pada Kecelakaan (P3K) untuk Kegiatan Pertanian di Desa Mojokembang Pacet
Authors: Rachmat Aulia Nadia , Rohma Dhani Mey , Santoso Mochamad Yusuf , Khairansyah Mades Darul , Amrullah Haidar Natsir , Anindita Galih , Arninputranto Wibowo 
Published: November 2024

Industri pertanian dari hulu ke hilir meliputi produksi, awal, distribusi, serta pengolahan lanjutan. Proses produksi terdiri dari beberapa kegiatan yaitu penanaman dan pemeliharaan tanaman. Produksi padi berupa gabah kering giling meningkat sebesar 1,93% dari tahun 2022 ke tahun 2023. Peningkatan produksi ini juga meningkatkan risiko kecelakaan kerja yang dialami pekerja di bidang pertanian. Petani memiliki risiko kecelakaan kerja berupa cedera akibat penggunaan alat dan mesin pertanian. Maka dari itu, petani perlu diberikan pelatihan tentang pertolongan pertama pada kecelakaan (P3K). Kegiatan pengabdian kepada masyarakat yang telah dilakukan meliputi pemberian materi tentang jenis cedera yang dapat diderita serta cara penanganannya. Kegiatan tersebut meningkatkan wawasan warga Desa Mojokembang Pacet tentang pentingnya keselamatan dan kesehatan kerja (K3) di sawah.
A educação patrimonial e os métodos de ensino na mesorregião do norte de minas gerais: os casos de Montes Claros e Mato Verde/MG
Authors: Melo Bernardes Brenda , Borsagli Alessandro , Sérgio Marques Amaro , Crispim Marçal Graziela 
Published: November 2024

O presente trabalho investiga a aplicação da educação patrimonial em instituições de ensino, com destaque para a produção de cartilhas, mapas mentais e murais de exposição por estudantes, enquanto meio de difusão da importância patrimonial dos bens culturais em espaços coletivos. A partir dessa abordagem são analisadas as metodologias de ensino para conhecimento e a valorização acerca do patrimônio e da formação da cidade de Mato Verde e de Montes Claros, que concentram expressivo patrimônio cultural, integrando a mesorregião do norte de Minas Gerais. Nesse sentido, define-se como objetivo geral deste artigo compreender a importância das ações educativas para a preservação da memória coletiva vinculada aos bens culturais, tendo como contexto as práticas conduzidas em duas instituições de ensino do norte de Minas Gerais. Utiliza-se como metodologia de pesquisa, além do levantamento de campo, a análise dos conceitos tratados por Grunberg e pelo Iphan relativos ao patrimônio, educação patrimonial e paisagem. Como resultado da pesquisa, ressalta-se que as experiências didáticas são fundamentais para fortalecer a importância da educação patrimonial como aliado na salvaguarda dos bens materiais e imateriais. Além disso, essas experiências incentivam o envolvimento das comunidades locais com o patrimônio cultural.
Abstract
The present work investigates the application of heritage education in educational institutions. It emphasis on the production of booklets, mind maps, and exhibition walls by students as a means of disseminating the heritage importance of cultural assets in collective spaces. From this approach, we analyse teaching methodologies for knowledge and appreciation of the heritage and formation of the cities of Mato Verde and Montes Claros. These cities concentrate significant cultural heritage integrating the mesoregion of northern Minas Gerais. In this sense, this article aims to understand the importance of educational actions for safeguarding collective memory linked to cultural assets. We take the practices conducted in two educational institutions in the north of Minas Gerais. The research methodology, in addition to the field survey, is the analysis of the concepts discussed by Grunberg and Iphan on heritage, heritage education, and landscape. As a result of the research, it is highlighted that didactic experiences are fundamental to strengthening the importance of heritage education as an ally in safeguarding material and immaterial assets. Furthermore, these experiences encourage the involvement of local communities with cultural heritage
A PRÁTICA DA LAVAGEM DAS MÃOS COMO INDICADOR DE HIGIENE
Authors: Silva Rodrigues Leidiane , Moura da Silva Anisia , Gonçalves de Oliveira e Silva Elissa , Cofani Costa Pomini Priscila 
Published: November 2024

A higienização das mãos é uma medida fundamental para prevenir infecções relacionadas à assistência à saúde (IRAS). Ao ser analisado os acadêmicos realizando o procedimento 77% não removeram os adornos, 72% realizaram o procedimento em menos tempo do que o recomenda e 66% não higienizaram todas as áreas das mãos, podemos concluir que existe uma discrepância entre o conhecimento teórico e a prática da higienização das mãos entre os acadêmicos. É necessário investir em medidas de aprimoramento da prática, como treinamentos práticos regulares, campanhas de conscientização e integração da técnica na rotina de ensino e avaliação. A Infecção Associada aos Cuidados de Saúde (IACS) é definida como aquela que surge durante a prestação de cuidados em um hospital ou outra instituição, sendo que não existia e nem estava em incubação quando foi realizada a admissão, inclui também infecções adquiridas no hospital, mas que se manifestam após a alta. Este problema assume cada vez maior importância no mundo, uma vez que, é uma importante causa de mortalidade e morbilidade, representando um acréscimo de consumo de recursos. A IACS apresenta muitas características que torna um componente importante de qualquer programa de segurança do doente, dentre as precauções básicas, a higienização das mãos é considerada a medida de maior impacto e comprovada eficácia na prevenção de IACS, e isto, deve-se ao fato de impedir a transmissão cruzada de microrganismos. Objetivo: Avaliado os procedimentos utilizados pelos acadêmicos em relação à higienização das mãos. Métodos: Pesquisa de campo, Quali-Quantitativa. Característica transversal, pois foi coletado dados em um único momento da pesquisa. Aplicado aos acadêmicos do curso de enfermagem, através de uma dinâmica utilizando tinta guache, com a tinta nas mãos cada um realizou os movimentos que necessários conforme preconiza a normativa 007 de 2019, ao final as partes das mãos que ficaram sem a tinta correspondem às áreas na qual o degermante não alcançou; e foi utilizada a estatística descritiva, pois foi realizado uma demonstração dos resultados em constância respectiva de percentuais e explanados em tabelas e gráficos. Resultados: Através desse trabalho foi analisado como os acadêmicos de enfermagem utilizam-se da técnica da lavagem das mãos.
PALAVRAS-CHAVE:
Higienização das mãos; Infecção hospitalar; Segurança do paciente.
Efektivitas Komsumsi Labu Siam Terhadap Peningkatan Hemoglobin pada Ibu Hamil
Authors: Ismi Wahyuni Nur , Sukmawati  
Published: November 2024

Anemia pada ibu hamil memiliki konsekuensi serius terhadap kesehatan ibu dan janin. Namun penanganan anemia dengan mengonsumsi tablet Fe memiliki banyak efek samping. Oleh karena itu diperlukan penanganannya melalui pendekatan komplementer dengan efek samping minim seperti mengkonsumsi makanan labu siam. Tujuan: Untuk mengetahui efektivitas konsumsi labu siam dalam meningkatkan kadar hemoglobin pada ibu hamil.
Metode: Penelitian ini menggunakan rancangan pretest-posttest. Jumlah sampel yang digunakan adalah sebanyak 30 orang ibu hamil. Pengambilan data kadar Hb toolkit Easy Touch GCHb. Analisis data dilakukan melalui t paired sample. Hasil: Rata-rata kadar Hb ibu sebelum konsumsi labu siam adalah 9,7 g/dL; sebelum konsumsi labu siam adalah 10,9 g/dL; labu siam efektif meningkatkan kadar Hb ibu hamil (p-value: 0,000 < 0,05).
Efektivitas Kunjungan Nifas Terhadap Pengurangan Ketidaknyamanan Fisik yang Terjadi pada Ibu Selama Masa Nifas di Wilayah Kerja Puskesmas Kecamatan Pulogadung Jakarta Tahun 2023
Authors: Farlikhatun Lili , Yanuarti Tuty 
Published: November 2024

Kunjungan selama nifas sering dianggap sangat tidak penting oleh ibu yang sedang dalam masa nifas di Wilayah Kerja Puskesmas Kecamatan Pulogadung bahwa dari 30 orang ibu yang sedang dalam masa nifas, hanya 7 orang yang berkunjung 4 kali ke fasilitas keehatan untuk mendapatkan pelayanan kesehatan nifas. Tujuan penelitian ini mengetahui efektivitas kunjungan nifas terhadap pengurangan ketidaknyaman fisik pada ibu selama masa nifas. Penelitian ini deskriptif korelasi dengan pendekatan waktu cross sectional. Sampelnya seluruh ibu nifas, teknik pengambilan sampel secara accidental sempling. Total sampel sebanyak 30. Penelitian dilakukan pada bulan November – Desember 2023. Hasil uji statistik chi-square terdapat nilai p - value= 0,000 ( < 0,05 ). Artinya terdapat hubungan yang signifikan antara kunjungan nifas dengan ketidaknyamanan fisik selama masa nifas pada ibu di Wilayah Kerja Puskesmas Pulogadung Tahun 2023. Diharapkan petugas kesehatan dapat memberikan edukasi tentang pentingnya kunjungan nifas yang baik selama masa nifas.