bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐Related Quality of Life and Cognitive Functioning in Pediatric Liver Transplant Recipients
Authors: Ohnemus Daniella , Neighbors Katie , Rychlik Karen , Venick Robert S. , Bucuvalas John C. , Sundaram Shikha S. , Ng Vicky L. , Andrews Walter S. , Turmelle Yumi , Mazariegos George V. , Sorensen Lisa G. , Alonso Estella M. ,   for Studies of Pediatric Liver Transplantation (SPLIT)
Published: September 2019

The goal of this work was to examine the change in health‐related quality of life (HRQOL) and cognitive functioning from early childhood to adolescence in pediatric liver transplantation (LT) recipients. Patients were recruited from 8 North American centers through the Studies of Pediatric Liver Transplantation consortium. A total of 79 participants, ages 11‐18 years, previously tested at age 5‐6 years in the Functional Outcomes Group study were identified as surviving most recent LT by 2 years and in stable medical follow‐up. The Pediatric Quality of Life 4.0 Generic Core Scale, Pediatric Quality of Life Cognitive Function Scale, and PROMIS Pediatric Cognitive Function tool were distributed to families electronically. Data were analyzed using repeated measures and paired t tests. Predictive variables were analyzed using univariate regression analysis. Of the 69 families contacted, 65 (94.2%) parents and 61 (88.4%) children completed surveys. Median age of participants was 16.1 years (range, 12.9‐18.0 years), 55.4% were female, 33.8% were nonwhite, and 84.0% of primary caregivers had received at least some college education. Median age at LT was 1.1 years (range, 0.1‐4.8 years). The majority of participants (86.2%) were not hospitalized in the last year. According to parents, adolescents had worse HRQOL and cognitive functioning compared with healthy children in all domains. Adolescents reported HRQOL similar to healthy children in all domains except psychosocial, school, and cognitive functioning (P = 0.02; P < 0.001; P = 0.04). Participants showed no improvement in HRQOL or cognitive functioning over time. For cognitive and school functioning, 60.0% and 50.8% of parents reported “poor” functioning, respectively (>1 standard deviation below the healthy mean). Deficits in HRQOL seem to persist in adolescence. Over half of adolescent LT recipients appear to be at risk for poor school and cognitive functioning, likely reflecting attention and executive function deficits.
Neutralizing the shamefulness judgements of materialistic buyer behavior: The role of price promotions and the smart‐shopper attribution
Authors: Zhang Yi , Mick David Glen 
Published: September 2019

AbstractAs a value and lifestyle of acquiring more things to attain happiness, materialism has been long condemned by religious leaders, philosophers, and psychologists, among others. This criticism comes also from American citizens who readily affix moral‐shamefulness judgments to their country's standing as a leading materialistic culture, while they continue, nonetheless, purchasing discretionary, and self‐presentational goods at breath‐taking levels. We integrate dispersed literature on materialism, moral psychology, American history, and retailing to propose that observers judge higher materialistic buyer behavior as being more morally shameful; however, we also propose that observers will reduce the harshness of their judgments when the buyer secures a favorable price promotion that has been shown in prior research to evoke the smart‐shopper attribution. Three studies provide supportive evidence, including the moderating role of different levels or types of price promotions on shamefulness judgments and the mediating role of the smart‐shopper attribution. Together these new insights reveal the substantive and theoretical knowledge value of considering materialism more intently from a moral psychology perspective and considering how retail promotions can influence materialism judgments and buying behavior. Discussion focuses on extensions of our findings in future research and for consumer education.
Benchmark rainfall verification of landfall tropical cyclone forecasts by operational ACCESS‐TC over China
Authors: Yu Zifeng , Chen Ying Jun , Ebert Beth , Davidson Noel E. , Xiao Yi , Yu Hui , Duan Yihong 
Published: September 2019

AbstractResults from object‐based verification of rainfall forecasts for landfalling tropical cyclones (TCs) over China during the period 2012–2015 are presented. The sample consists of 25 landfall events and 133 operational numerical forecasts from the TC version of the Australian Community Climate and Earth System Simulator. Mean equitable threat scores, probabilities of detection and false alarm ratios for the 30 mm isohyet for the unadjusted forecasts at 0–6 hr (essentially the initialization) are (0.23, 0.55, 0.65), while the performance measures of 24 hr forecast accumulations are the best for the 0–24 hr forecast (0.37, 0.67, 0.40) and then worsen to (0.16, 0.38, 0.66) for the 48–72 hr forecast. Forecast ability also decreases with the increase in rainfall amount. The contiguous rain area (CRA) verification method is used to diagnose the source of systematic errors from the displacement, rotation, volume and pattern of the forecasted rain fields. Results show that the errors are mostly from rainfall patterns, followed by displacement errors, particularly for very heavy rain. After application of the displacement and rotation adjustments of the CRA method, averaged errors improve by about 15%. Results suggest that rainfall prediction will continue to improve with improved track prediction, but more work is needed on model initialization and the prediction of TC structure. The study has uncertainty related to the limited sample size, which could cause large variability, particularly for heavy rainfall at 6 and 72 hr. However, the results still represent a useful benchmark for future verification of landfalling TCs.
A Combination of Pharmacophore and Docking‐based Virtual Screening to Discover new Tyrosinase Inhibitors
Authors: Vittorio Serena , Seidel Thomas , Germanò Maria Paola , Gitto Rosaria , Ielo Laura , Garon Arthur , Rapisarda Antonio , Pace Vittorio , Langer Thierry , De Luca Laura 
Published: September 2019

AbstractMelanogenesis controls the formation of melanin pigment whose overproduction is related to various hyperpigmentary disorders in humans. Tyrosinase is a type‐3 copper enzyme involved in the rate limiting step of melanin synthesis, therefore its inhibition could represent an efficient way for the development of depigmenting agents. In this work, a combination of pharmacophore and docking‐based studies has been employed to screen two in‐house 3D compound databases containing about 2,000 molecules from natural and synthetic sources. As result we selected two “hit compounds” which proved to inhibit tyrosinase activity showing IC50 values in the micromolar range.
Implicit implementation of the stabilized non‐ordinary state‐based peridynamic model
Authors: Li Pan , Hao Zhiming , Yu Shaorong , Zhen Wenqiang 
Published: September 2019

SummaryThis paper presents a stabilized non‐ordinary state‐based peridynamic model, in which the numerical instability problems induced by the zero‐energy mode are overcome. The implicit discretization formulation of this model is proposed. In order to depict the progressively damaging process in coarse discretization conditions, a bilinear damage model based on the influence function is developed. An implicit implementation of the stabilized non‐ordinary state‐based peridynamic model is presented, in which an iterative procedure based on the secant stiffness method is used to solve the nonlinear problem. This method does not need to introduce a damping term in solving static problems, and relatively large load steps are desirable. Five numerical examples are analyzed to demonstrate the effectiveness of the present method for quantitatively simulating the quasi‐static crack propagation problems.
Learning from usability testing of an arts‐based knowledge translation tool for parents of a child with asthma
Authors: Archibald Mandy M. , Scott Shannon D. 
Published: September 2019

AbstractAimDigital, art‐ and story‐based resources can be viable and engaging knowledge translation strategies in health care. Understanding the usability of these approaches can help maximize their impact. The aim of this work is to understand what aspects of ‘My Asthma Diary’, an art‐based digital knowledge translation tool for parents of children with asthma, has an impact on usability.DesignSequential explanatory mixed methods pilot study.MethodsEighteen parents of children with asthma reviewed ‘My Asthma Diary’ in a paediatric emergency department and completed a usability questionnaire. Follow‐up interviews were conducted with five parents and analysed with qualitative description.ResultsWe identified four themes which complemented the quantitative results: (a) the eBooks are relatable and mirror personal experience; (b) the digital format is convenient and easy to navigate; (c) the narrative structure aids learning; and (d) the narrative and illustrations are synergistic. We summarize core usability considerations for subsequent research and creative knowledge translation tool development in other contexts.
Dealing with adolescents' recurrent pain problems in school health care—Swedish school nurses' view
Authors: Golsäter Marie , Nilsson Stefan , Wigert Helena 
Published: September 2019

AbstractAimTo explore school nurses' strategies for supporting adolescents with recurrent pain.DesignAn explorative inductive qualitative design.MethodTwenty‐one Swedish school nurses were interviewed, and the interviews were subjected to content analysis.ResultsThe findings show that the nurses are aware that recurrent pain problems are common among the adolescents. In their attempt to support these adolescents, the nurses describe how they are striving in attempts to acquire an understanding of the adolescents' situation, to understand the cause of the pain problem and to devise strategies that can be used to help the adolescents handle the situation.
Reduced‐order LQG/LTR procedure for the plant output side
Authors: Ishihara Tadashi , Zheng Liang‐An 
Published: September 2019

SummaryIt is commonly believed that reduced‐order observers, including reduced‐order Kalman filters, cannot be used in the loop transfer recovery (LTR) design of the plant output side. In contrast to common understanding, we show that, at least for nonminimum‐phase plants, the reduced‐order Kalman filter can be used in the linear‐quadratic‐Gaussian (LQG)/LTR design of the plant output side with clear meaning in systems theory. The key concept is to regard a reduced‐order Kalman filter as a high‐gain full‐order Kalman filter. For the reduced‐order LQG controller, we examine the asymptotic property achieved by applying the recovery procedure used in the full‐order LQG/LTR design. Using the equivalent full‐order Kalman filter, we find that the sensitivity property of the reduced‐order LQG controller is asymptotically equivalent to that of a high‐gain partial output injection system. Motivated by this result, we propose the reduced‐order LQG/LTR procedure taking the high‐gain partial output injection system as a target. Some target properties are discussed to clarify the difference from the full‐order design. A multivariable design example is presented to show that the procedure provides a systematic design of a reduced‐order controller with optimality consideration.
Crosslinking of polyamides using dianhydrides, diacid chloride and dialdehyde: a promising approach for water treatment
Authors: Zahra Manzar , Zulfiqar Sonia , Skene William G , Sarwar Muhammad Ilyas 
Published: September 2019

AbstractNew crosslinked polyamides were successfully produced from the condensation of pre‐synthesized monomer, 5‐(2,2,2‐trifluoroacetamido)isophthaloylchloride (TFAIAC) and diamines at low temperature. These polyamides were used as promising metal‐chelating adsorbents due to the presence of O and N donor sites on the crosslinked polyamides. For this purpose, trifluoroacetic anhydride was used to protect the amino group of 5‐aminoisophthalic acid, thus generating 5‐(2,2,2‐trifluoroacetamido)isophthalic acid (TFAIA). TFAIA was converted into TFAIAC using oxalyl chloride, which was exploited as a suitable monomer for the synthesis of aromatic polyamides. Amino groups were then set free under basic conditions and the crosslinking was carried out through amino groups present on the polyamide chains with different dianhydrides, isophthaloyl chloride and 2,5‐thiophenedicarboxaldehyde. The synthesis of monomers and polymers was confirmed by Fourier transform infrared, 1H and 13C NMR spectroscopy and molar masses of the polyamides were measured by gel permeation chromatography. The crosslinked macromolecules were found to possess enough chain alignment as depicted by their XRD patterns. The thermal stability of the crosslinked polyamides was increased as their decomposition temperatures were improved from 420 to 619 °C. Metal ion uptake was scrutinized through atomic absorption spectroscopy with 83%–85% adsorption capacity at optimized parameters, i.e. a contact time of 3 h at pH 6. The mechanism of adsorption was further investigated through the Freundlich and Langmuir adsorption isotherms. The results reveal that uptake of metal ions followed monolayer adsorption of cations owing to coordination to electronegative centers on the macromolecules, confirming the Langmuir adsorption model. © 2019 Society of Chemical Industry
Proteome Oxidative Modifications and Impairment of Specific Metabolic Pathways During Cellular Senescence and Aging
Authors: Hamon Marie‐Paule , Ahmed Emad K. , Baraibar Martín A. , Friguet Bertrand 
Published: September 2019

AbstractAccumulation of oxidatively modified proteins is a hallmark of organismal aging in vivo and of cellular replicative senescence in vitro. Failure of protein maintenance is a major contributor to the age‐associated accumulation of damaged proteins that is believed to participate to the age‐related decline in cellular function. In this context, quantitative proteomics approaches, including 2‐D gel electrophoresis (2‐DE)‐based methods, represent powerful tools for monitoring the extent of protein oxidative modifications at the proteome level and for identifying the targeted proteins, also referred as to the “oxi‐proteome.” Previous studies have identified proteins targeted by oxidative modifications during replicative senescence of human WI‐38 fibroblasts and myoblasts and have been shown to represent a restricted set within the total cellular proteome that fall in key functional categories, such as energy metabolism, protein quality control, and cellular morphology. To provide mechanistic support into the role of oxidized proteins in the development of the senescent phenotype, untargeted metabolomic profiling is also performed for young and senescent myoblasts and fibroblasts. Metabolomic profiling is indicative of energy metabolism impairment in both senescent myoblasts and fibroblasts, suggesting a link between oxidative protein modifications and the altered cellular metabolism associated with the senescent phenotype of human myoblasts and fibroblasts.
Controlled ring‐expansion polymerization of thiiranes based on cyclic aromatic thiourethane initiator
Authors: Takahashi Akira , Yuzaki Ryu , Ishida Yoshihito , Kameyama Atsushi 
Published: September 2019

ABSTRACTRing‐expansion polymerization (REP) of thiiranes was investigated using 3H‐benzothiazol‐2‐one (BT) as the cyclic aromatic thiourethane initiator in the presence of tetrabutylammonium chloride (TBAC) catalyst. The polymerization proceeded in a well‐controlled manner to afford cyclic polysulfides with one BT moiety per macrocycle, as confirmed by MALDI‐TOF MS spectroscopy. Differential scanning calorimetry (DSC) measurement of the obtained cyclic polysulfides revealed slight decrease in the glass‐transition temperature as the increase in the molecular weight, supporting the cyclic topology of the products. Postpolymerization of thiiranes using the BT‐initiated cyclic polysulfide as the macroinitiator afforded the ring‐expanded product while maintaining the narrow polydispersity and well‐defined cyclic structure, which enabled precise synthesis of cyclic block copolymer with different thiirane combination. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2442–2449
Changes in mean flow and atmospheric wave activity in the North Atlantic sector
Authors: Paeth Heiko , Pollinger Felix 
Published: September 2019

AbstractIn recent years, the midlatitudes are characterized by more intense heatwaves in summer and sometimes severe cold spells in winter that might emanate from changes in atmospheric circulation, including synoptic‐scale and planetary wave activity in the midlatitudes. In this study, we investigate the heat and momentum exchange between the mean flow and atmospheric waves in the North Atlantic sector and adjacent continents by means of the physically consistent Eliassen–Palm flux diagnostics applied to reanalysis and forced climate model data. In the long‐term mean, momentum is transferred from the mean flow to atmospheric waves in the northwest Atlantic region, where cyclogenesis prevails. Further downstream over Europe, eddy fluxes return momentum to the mean flow, sustaining the jet stream against friction. A global climate model is able to reproduce this pattern with high accuracy. Atmospheric variability related to atmospheric wave activity is much more expressed at the intraseasonal rather than the interannual time‐scale. Over the last 40 years, reanalyses reveal a northward shift of the jet stream and a weakening of intraseasonal weather variability related to synoptic‐scale and planetary wave activity. This pertains to the winter and summer seasons, especially over central Europe, and correlates with changes in the North Atlantic Oscillation as well as regional temperature and precipitation. A very similar phenomenon is found in a climate model simulation with business‐as‐usual scenario, suggesting an anthropogenic trigger in the weakening of intraseasonal weather variability in the midlatitudes.
Major dams and the challenge of achieving “No Net Loss” of biodiversity in the tropics
Authors: Jones Isabel L. , Bull Joseph W. 
Published: September 2019

AbstractDam construction is booming across tropical regions critical for global biodiversity and ecosystem service provision. The principle of “No Net Loss” (NNL)—under which biodiversity impacts of development projects are quantified and fully mitigated—is being increasingly applied to large infrastructure development worldwide, including dams. We discuss the impacts of major tropical dams and associated implementation of NNL policies and outline three major challenges in achieving NNL: (1) overcoming practicalities implementing NNL in highly connected river systems over large spatio‐temporal scales; (2) the stakes are high if NNL fails because tropical regions are hyper‐diverse, rich in species endemism, and difficult to restore; and (3) inclusion of ecosystem services in NNL design is necessary due to the importance of tropical biodiversity for ecosystem service provision at multiple spatial scales. Overcoming these challenges is crucial when hundreds of dams are planned and under construction across the tropics, many potentially subject to NNL policies.
Effect of Reducing Agent NaBH4 on Photocatalytic Properties of Bi/BiOBr/Bi2WO6 Composites
Authors: Gao Zhanyao , Yao Binghua , Ji Liangliang , Xu Tiantian 
Published: September 2019

AbstractWith the improvement of human living standards, a large amount of drugs in the fields of medicine, agriculture, animal husbandry and other fields have being invested and used, resulting in an increasing demand for cleaning antibiotics to clean water sources. In this study, Bi/BiOBr/Bi2WO6 composite photocatalyst was successfully synthesized by ahydrothermal method with BiOBr as the precursor. The effect of reducing agent sodium borohydride (NaBH4) on the structure and photocatalytic activity of the composite was studied. The results showed that most active photocatalyst was obtained when 20 mmol/L of sodium borohydride was used. The degradation of norfloxacin on Bi/BiOBr/Bi2WO6 reached 96.1%, which was about 6.7% higher than that on BiOBr/Bi2WO6. And the reaction rate was 1.4 times of BiOBr/Bi2WO6. The heterojunction formed by the three substances was the main reason for the enhanced catalytic activity. These results were beneficial for the practical application of high performance Bi/BiOBr/Bi2WO6 photocatalytic materials.
Iodine‐DMSO‐Catalyzed Chemoselective Biomimetic Aromatization of Tetrahydro‐β‐carbolines‐3‐carboxylic Acid: Mechanism Study with DFT‐Calculation
Authors: Gaikwad Sunil V. , Nadimetla Dinesh N. , Kobaisi Mohammad Al , Devkate Manisha , Joshi Rekha , Shinde Rohit G. , Gaikwad Milind V. , Nikalje Milind D. , Bhosale Sheshanath V. , Lokhande Pradeep D. 
Published: September 2019

AbstractA new protocol for the chemoselective aromatization of tetrahydro‐β‐carboline‐3‐carboxylic acids to direct biomimetic one step synthesis of β‐carboline‐3‐carboxylic acids 2 A‐L using catalytic amount of I2 in DMSO/H+ produces very good yield. This method was also successfully extended for the aromatization of tetrahydro‐β‐carboline‐3‐methyl esters 5 A‐G as well as one‐step synthesis of Marinacarbolines‐D analog, respectively. Further, the mechanism and role of iodine–DMSO in aromatization has been studied by Density Functional Theory Calculation.
Jack of all trades and master of knowledge: The role of diversification in new distant knowledge integration
Authors: Nagle Frank , Teodoridis Florenta 
Published: September 2019

AbstractResearch SummaryWe consider the role of individual‐level diversification as a mechanism through which skilled researchers engage in successful exploration—recognizing and integrating new knowledge external to one's domains of expertise. To approach an ideal experiment, we (a) employ a matching procedure and (b) exploit the unexpected adoption of Microsoft Kinect as a motion‐sensing technology in research. We evaluate the impact of Kinect and its embodiment of new knowledge on a set of ability‐matched, diversity‐varying researchers without prior experience in motion‐sensing and find that diversified researchers explore more successfully than their more specialized peers. We also examine the role of personal preferences and professional incentives as antecedents of diversification and find that culture, age and intellectual freedom are positively associated with the propensity to diversify successfully.Managerial SummaryOrganizations where R&D is core to driving competitive advantage face important tradeoffs when hiring researchers. Specifically, diverse combinations of knowledge generate the most impactful discoveries. Yet, coordinating such combinations increasingly requires larger teams as knowledge accumulation causes researchers to specialize in narrower areas. How should organizations achieve the best balance? We argue and show evidence that diversified researchers, individuals routinely criticized for their lack of knowledge depth, are more likely than specialized researchers of similar ability to integrate new knowledge from beyond their domains of expertise to create impactful innovations. Therefore, organizations aiming to create competitive advantage by pushing the boundaries of knowledge should carefully consider the nuanced tradeoffs between specialized and diversified researchers when strategizing about hiring the optimal types of expertise.