bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fouling on a Multistage Axial Compressor in the Presence of a Third Substance at the Particle/Surface Interface
Authors: Aldi Nicola , Casari Nicola , Dainese Devid , Morini Mirko , Pinelli Michele , Spina Pier Ruggero , Suman Alessio 
Published: August 2018

Solid particle ingestion is one of the principal degradation mechanisms in the compressor and turbine sections of gas turbines. In particular, in industrial applications, the micro-particles not captured by the air filtration system can cause deposits on blades and, consequently, can result in a decrease in compressor performance. It is of great interest to the industry to determine which zones of the compressor blades are impacted by these small particles. However, this information often refers to single stage analysis.
This paper presents three-dimensional numerical simulations of the micro-particle ingestion (0.15 μm – 1.50 μm) in a multistage (i.e. eight stage) subsonic axial compressor, carried out by means of a commercial CFD code. Particle trajectory simulations use a stochastic Lagrangian tracking method that solves the equations of motion separately from the continuous phase.
The effects of humidity, or more generally, the effects of a third substance at the particle/surface interface (which is considered one of the major promoters of fouling) is then studied. The behavior of wet and oiled particles, in addition to the usual dry particles, is taken into consideration. In the dry case, the particle deposition is established only by using the sticking probability. This quantity links the kinematic characteristics of particle impact on the blade with the fouling phenomenon. In the other two cases, the effect of the presence of a third substance at the particle/surface interface is considered by means of an energy-based model. Moreover, the influence of the tangential impact velocity on particle deposition is analyzed.
Introducing the effect of a third substance, such as humidity or oil, the phenomenon of fouling concerns the same areas of the multistage compressor. The most significant results are obtained by combining the effect of the third substance with the effect of the tangential component of the impact velocity of the particles. The deposition trends obtained with these conditions are comparable with those reported in literature, highlighting how the deposits are mainly concentrated in the early stages of a multistage compressor. Particular fluid dynamic phenomena, such as corner separations and clearance vortices, strongly influence the location of particle deposits.
Development and Testing of the Hybrid Electric Drive Program for the Navy’s DDG 51 Class Ships
Authors: Buonamici Gianfranco , Schauble Michael 
Published: August 2018

This paper will discuss the development and testing of an electric drive option designed for the propulsion system of the US Navy’s DDG 51 Class ships. It will briefly explain the history of the Hybrid Electric Drive (HED) program, including that of its predecessor, Proof of Concept (PoC), and the HED’s planned shipboard installation schedule.
Operating at lower ship speeds, in a range where the currently installed propulsion gas turbines are less fuel efficient, the HED is expected to increase the ship’s fuel economy, allowing the ship to remain on station accomplishing its mission for a longer period of time. This paper will discuss how the gas turbine propulsion system, in concert with the HED, will be used to provide the most fuel efficient drive combination for various operating scenarios. Also covered will be a description of the major stakeholders involved in the HED’s development and implementation along with some of the constraints and challenges that were encountered in the testing phase of the program, both at the OEM facilities and at the US Navy’s Land Based Engineering Site (LBES) in Philadelphia PA.
Planned fuel economy testing results obtained at the LBES facility will also be presented, intended to determine an estimate of the fuel savings that can be expected when the system is first placed in service on USS TRUXTUN (DDG 103) July 2018.
Development and Testing of a Gas Turbine Engine Combustion Air Inlet Protection Shroud for the USMC Amphibious Combat Vehicle
Authors: Gastopoulos Thomai , McGinn Patricia , Lawton Joseph 
Published: August 2018

The Marine Corps Systems Command is evaluating alternative propulsion systems to achieve high water speed for the future USMC Amphibious Combat Vehicle (ACV). A gas turbine engine is one of the propulsion systems evaluated. The primary risk of operating a gas turbine engine in the ACV is power loss due to the ingestion of marine contaminants such as saltwater mist in the air, saltwater spray generated from the vehicle operation, green water wash caused by the operation of the vehicle in the surf zone or in rough seas, and hard particles such as sand present in the marine environment.
The Auxiliary Ships and New Acquisition Support Branch (Code 425) of the Naval Surface Warfare Center, Philadelphia Division conducted a study to assist the Marine Corps Systems Command in assessing the feasibility of using a gas turbine engine as a propulsion system on future USMC ACVs. The study was focused on developing and testing a gas turbine intake solution for the ACV that can remove saltwater from the intake airstream of the notional 3,000 horsepower ACV engine.
Code 425 developed a two-part solution for the intake of the ACV. The first part of the solution is the Combustion Air Protection Shroud (CAPS) located at the entrance of the engine intake and designed to protect the ACV engine from green water wash by elevating the intake above the ACV deck. The second part of the solution is a gas turbine intake filtration system located downstream of the intake shroud and designed to remove marine contaminants that enter the intake shroud.
A reduced-scale model of the CAPS was designed by Code 425 in conjunction with Gibbs & Cox and tested at the Davidson Laboratory High Speed Test Basin at the Stevens Institute of Technology to determine the optimum extension height of the CAPS to protect the engine intake. This paper covers the design and testing of the CAPS. The results showed that a 2.67 ft. tall CAPS with selectively closeable air intake louvers is sufficient to keep out saltwater from the ACV gas turbine engine.
Fuel Variation Effects in Propagation and Stabilization of Turbulent Counter-Flow Premixed Flames
Authors: Abbasi-Atibeh Ehsan , Jella Sandeep , Bergthorson Jeffrey M. 
Published: August 2018

Sensitivity to stretch and differential diffusion of chemical species are known to influence premixed flame propagation, even in the turbulent environment where mass diffusion can be greatly enhanced. In this context, it is convenient to characterize flames by their Lewis number (Le), a ratio of thermal-to-mass diffusion. The work reported in this paper describes a study of flame stabilization characteristics when the Le is varied. The test data is comprised of Le ≪ 1 (Hydrogen), Le ≈ 1 (Methane), and Le > 1 (Propane) flames stabilized at various turbulence levels.
The experiments were carried out in a Hot exhaust Opposed-flow Turbulent Flame Rig (HOTFR), which consists of two axially-opposed, symmetric turbulent round jets. The stagnation plane between the two jets allows the aerodynamic stabilization of a flame, and clearly identifies fuel influences on turbulent flames. Furthermore, high-speed Particle Image Velocimetry (PIV), using oil droplet seeding, allowed simultaneous recordings of velocity (mean and rms) and flame surface position.
These experiments, along with data processing tools developed through this study, illustrated that in the mixtures with Le ≪ 1, turbulent flame speed increases considerably compared to the laminar flame speed due to differential diffusion effects, where higher burning rates compensate for the steepening average velocity gradient, and keeps these flames almost stationary as bulk flow velocity increases.
These experiments are suitable for validating the ability of turbulent combustion models to predict lifted, aerodynamically-stabilized flames. In the final part of this paper, we model the three fuels at two turbulence intensities using the FGM model in a RANS context. Computations reveal that the qualitative flame stabilization trends reproduce the effects of turbulence intensity, however, more accurate predictions are required to capture the influences of fuel variations and differential diffusion.
Large-Eddy Simulation of Corner Separation in a Compressor Cascade
Authors: Min Byung-Young , Joo Jongwook , Mendoza Jomar , Lee Jin , Xia Guoping , Medic Gorazd 
Published: August 2018

In this paper, wall-resolved LES computations for a compressor cascade from Ecole Centrale de Lyon [1] are presented. A computational grid containing about 600 million computational cells was used in these simulations. This grid resolves the details of tripping strips used in the experiments, located near the leading edge of the blade on both suction and pressure sides. Endwall turbulent boundary layer at cascade inlet was measured to be at a momentum thickness based Reynolds number of about 7000 to 8000, with quite a bit of variation in the pitchwise direction. In order to avoid the cost of simulating the entire duct upstream of the cascade, and any auxiliary flat plate boundary layer simulations, the inlet fluctuations for LES computations were generated using digital filtering method for synthetic turbulence generation [27]. Turbulence statistics from a database of high fidelity eddy simulations of flat plate boundary layers (at similar Reynolds numbers) from KTH Royal Institute of Technology in Stockholm [28] were used to fully define the properties of the cascade inlet boundary layer.
In this paper, time-averaged results from three LES computations for this configuration are presented — one with no inlet fluctuations at the cascade endwall at the domain inlet, and then two computations with inlet fluctuations and boundary layers at Reθ of 7000 and 8183. These provide a sensitivity of LES predictions of corner separation in the cascade to the boundary layer thickness at cascade inlet.
A comparison of these simulations with prior DDES (and RANS) simulations from UTRC [26], as well as existing LES results from Ecole Centrale de Lyon [12], allows to further the understanding of critical elements of the endwall flow physics. More specifically, it provides more insight into which phenomena need to be sufficiently resolved (e.g. horseshoe vortex) in order to capture both the average behavior of the corner separation, as well as its unsteady dynamics. In addition, it provides new information which will help define best practice guidelines for the use of eddy simulations to resolve endwall features in compressors at off-design conditions.
Implications of parental lifestyle changes and education level on adolescent offspring weight: a population based cohort study - The HUNT Study, Norway
Authors: Naess Marit , Sund Erik R , Holmen Turid Lingaas , Kvaløy Kirsti 
Published: August 2018

ObjectiveObesity tends to cluster in families reflecting both common genetics and shared lifestyle patterns within the family environment. The aim of this study was to examine whether parental lifestyle changes over time, exemplified by changes in weight and physical activity, could affect offspring weight in adolescents and if parental education level influenced the relationship.Design, setting and participantsThe population-based cohort study included 4424 parent-offspring participants from the Nord-Trøndelag Health Study, Norway. Exposition was parental change in weight and physical activity over 11 years, and outcome was offspring weight measured in z-scores of body mass index (BMI) in mixed linear models.ResultsMaternal weight reduction by 2–6 kg was significantly associated with lower offspring BMI z-scores: −0.132 (95% CI −0.259 to −0.004) in the model adjusted for education. Parental weight change displayed similar effect patterns on offspring weight regardless of parents’ education level. Further, BMI was consistently lower in families of high education compared with low education in the fully adjusted models. In mothers, reduced physical activity level over time was associated with higher BMI z-scores in offspring: 0.159 (95% CI 0.030 to 0.288). Associations between physical activity change and adolescent BMI was not moderated by parental education levels.ConclusionLifestyle changes in mothers were associated with offspring BMI; reduced weight with lower—and reduced physical activity with higher BMI. Father’s lifestyle changes, however, did not significantly affect adolescent offspring’s weight. Overall, patterns of association between parental changes and offspring’s BMI were independent of parental education levels, though adolescents with parents with high education had lower weight in general.
Venous sinus stenting for idiopathic intracranial hypertension: a systematic review and meta-analysis
Authors: Nicholson Patrick , Brinjikji Waleed , Radovanovic Ivan , Hilditch Christopher Alan , Tsang Anderson Chun On , Krings Timo , Mendes Pereira Vitor , Lenck Stéphanie 
Published: August 2018

BackgroundStenting of the intracranial venous sinuses is used as a treatment in certain cases of idiopathic intracranial hypertension (IIH). Interest in, and experience of, this technique is growing, particularly in recent years. We sought to provide an updated systematic review and meta-analysis of the use of venous stenting in these patients, examining clinical outcomes.MethodsA literature search of venous stenting in IIH patients was performed. Using random-effects meta-analysis, we evaluated the following outcomes: clinical resolution of papilledema; headaches and pulsatile tinnitus; recurrence of symptoms after stenting; and complications.ResultsTwenty articles from 18 different centers were included. In a total of 474 patients. 418 were female (88%). The mean age of the patients was 35, while the mean body mass index (BMI) was 35 kg/m2. Median follow-up was 18 months. The overall rate of improvement in papilloedema was 93.7% (95% CI 90.5% to 96.9%), while the overall rate of improvement or resolution of headache was 79.6% (95% CI 73.3% to 85.9%). Pulsatile tinnitus resolved in 90.3% (95% CI 83.8% to 96.70%), while the overall rate of recurrence of IIH symptoms after stenting was 9.8% (95% CI 6.7% to 13%). The rate of major complications was 1.9% (95% CI 0.07% to 3.1%).ConclusionsVenous sinus stenting in patients with IIH who are refractory to medical therapy appears to have an excellent safety profile and is associated with significant improvements in headaches, pulsatile tinnitus, and papilledema.
Comparison of quantitative multiple-breath specific ventilation imaging using colocalized 2D oxygen-enhanced MRI and hyperpolarized 3He MRI
Authors: Arai Tatsuya J. , Horn Felix C. , Sá Rui Carlos , Rao Madhwesha R. , Collier Guilhem J. , Theilmann Rebecca J. , Prisk G. Kim , Wild Jim M. 
Published: August 2018

Two magnetic resonance specific ventilation imaging (SVI) techniques, namely, oxygen-enhanced proton (OE-1H) and hyperpolarized 3He (HP-3He), were compared in eight healthy supine subjects [age 32 (6) yr]. An in-house radio frequency coil array for 1H configured with the 3He transmit-receive coil in situ enabled acquisition of SVI data from two nuclei from the same slice without repositioning the subjects. After 3 × 3 voxel downsampling to account for spatial registration errors between the two SV images, the voxel-by-voxel correlation coefficient of two SV maps ranged from 0.11 to 0.63 [0.46 mean (0.17 SD); P < 0.05]. Several indexes were analyzed and compared from the tidal volume-matched SV maps: the mean of SV log-normal distribution (SVmean), the standard deviation of the distribution as a measure of SV heterogeneity (SVwidth), and the gravitational gradient (SVslope). There were no significant differences in SVmean [OE-1H: 0.28 (0.08) and HP-3He: 0.32 (0.14)], SVwidths [OE-1H: 0.28 (0.08) and HP-3He: 0.27 (0.10)], and SVslopes [OE-1H: −0.016 (0.006) cm−1 and HP-3He: −0.013 (0.007) cm−1]. Despite the statistical similarities of the population averages, Bland-Altman analysis demonstrated large individual intertechnique variability. SDs of differences in these indexes were 42% (SVmean), 46% (SVwidths), and 62% (SVslopes) of their corresponding overall mean values. The present study showed that two independent, spatially coregistered, SVI techniques presented a moderate positive voxel-by-voxel correlation. Population averages of SVmean, SVwidth, and SVslope were in close agreement. However, the lack of agreement when the data sets were analyzed individually might indicate some fundamental mechanistic differences between the techniques. NEW & NOTEWORTHY To the best of our knowledge, this is the first cross-comparison of two different specific ventilation (SV) MRI techniques in the human lung (i.e., oxygen-enhanced proton and hyperpolarized 3He). The present study showed that two types of spatially coregistered SV images presented a modest positive correlation. The two techniques also yielded similar population averages of SV indexes such as log-normal mean, SV heterogeneity, and the gravitational slope, albeit with some intersubject variability.
Impact of Biomarker-based Design Strategies on the Risk of False-Positive Findings in Targeted Therapy Evaluation
Authors: Vo Tat-Thang , Vivot Alexandre , Porcher Raphaël 
Published: August 2018

Abstract

Purpose:
When there is more than one potentially predictive biomarker for a new drug, the drug is often evaluated in different subpopulations defined by different biomarkers. We aim to (i) estimate the risk of false-positive findings with this approach and (ii) evaluate the cross-validated adaptive signature design (CVASD) as a potential alternative.

Experimental Design:
By using numerically simulated data, we compare the current approach and the CVASD across different settings and scenarios. We consider three strategies for CVASD. The first two CVASD strategies are different in terms of the partitioning of the overall significance level (between the population test and the subgroup test). In the third CVASD strategy, the order of the two tests is reversed, that is, the population test is realized when the prioritized subgroup test is not statistically significant.

Results:
The current approach results in a high risk of false-positive findings, whereas this risk is close to the nominal level of 5% once applying the CVASD, regardless of the strategy. When the treatment is equally effective to all patients, only the CVASD strategies could specify correctly the absence of a sensitive subgroup. When the treatment is only effective for some sensitive responders, the third CVASD strategy stands out by its ability to correctly identify the predictive biomarker(s).

Conclusions:
The drug–biomarker coevaluation based on a series of independent enrichment trials can result in a high risk of false-positive findings. CVASD with some appropriate adjustments can be a good alternative to overcome this multiplicity issue.
Is GPNMB the Achilles' Heel of Mo-MDSC While Marking Their Suppressive Activity?
Authors: Colombo Mario P. 
Published: August 2018

Abstract
Glycoprotein nonmetastatic B/DC-Hil/Osteoactivin on myeloid-derived suppressor cells impairs T lymphocytes through the binding of Syndecan-4, delineating a new checkpoint pair to be targeted perhaps in combination with PD-1/PD-L1 blockage.
See related article by Kobayashi et al., p. 828
Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma
Authors: Dower Christopher M. , Bhat Neema , Gebru Melat T. , Chen Longgui , Wills Carson A. , Miller Barbara A. , Wang Hong-Gang 
Published: August 2018

Abstract
Neuroblastoma is the most common extracranial solid malignancy in the pediatric population, accounting for over 9% of all cancer-related deaths in children. Autophagy is a cell self-protective mechanism that promotes tumor cell growth and survival, making it an attractive target for treating cancer. However, the role of autophagy in neuroblastoma tumor growth and metastasis is largely undefined. Here we demonstrate that targeted inhibition of an essential autophagy kinase, unc-51 like autophagy kinase 1 (ULK1), with a recently developed small-molecule inhibitor of ULK1, SBI-0206965, significantly reduces cell growth and promotes apoptosis in SK-N-AS, SH-SY5Y, and SK-N-DZ neuroblastoma cell lines. Furthermore, inhibition of ULK1 by a dominant-negative mutant of ULK1 (dnULK1K46N) significantly reduces growth and metastatic disease and prolongs survival of mice bearing SK-N-AS xenograft tumors. We also show that SBI-0206965 sensitizes SK-N-AS cells to TRAIL treatment, but not to mTOR inhibitors (INK128, Torin1) or topoisomerase inhibitors (doxorubicin, topotecan). Collectively, these findings demonstrate that ULK1 is a viable drug target and suggest that inhibitors of ULK1 may provide a novel therapeutic option for the treatment of neuroblastoma. Mol Cancer Ther; 17(11); 2365–76. ©2018 AACR.
Building a Modern Political Ecology and the Need to Demystify Political Meritocracy
Authors: Liu Jingxi , Bihler Anja 
Published: August 2018

Abstract
To construct socialism with Chinese characteristics, advance socialist democracy, and establish a political ecology for socialism with Chinese characteristics, we should devote our efforts toward building a stronger political system and strengthening the rule of law and democracy. Important projects, such as the anti-corruption campaign, mass-line education, or team building for government officials should be guided by the spirit of democracy and the rule of law and proceed in an orderly and regulated manner. Still, voices in support of political meritocracy have become increasingly audible in Chinese political and academic circles, supporting a political phenomenon completely incompatible with the goal of building a socialist democracy. Meritocracy as a political system entails a high degree of uncertainty, unsustainability, and risk and is essentially just a modified version of the rule of man or, to put it differently, the rule of man “2.0.” Its fatal weakness is its inability to resolve two fundamental problems related to the legitimacy of political power: Where does power originate, and how can we control it? An important theoretical prerequisite for building a clean political ecology is thus to demystify meritocracy and dispel any popular myths surrounding it.
Eris and Epos
Authors: Christensen Joel P. 
Published: August 2018

Abstract
This article examines the development of the theme of eris in Hesiod and Homer. Starting from the relationship between the destructive strife in the Theogony (225) and the two versions invoked in the Works and Days (11–12), I argue that considering the two forms of strife as echoing zero and positive sum games helps us to identify the cultural and compositional force of eris as cooperative competition. After establishing eris as a compositional theme from the perspective of oral poetics, I then argue that it develops from the perspective of cosmic history, that is, from the creation of the universe in Hesiod’s Theogony through the Homeric epics and into its double definition in the Works and Days. To explore and emphasize how this complementarity is itself a manifestation of eris, I survey its deployment in our major extant epic poems.