bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed- Versus Adjustable-Loop Femoral Cortical Suspension Devices for Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Biomechanical Studies
Authors: Houck Darby A. , Kraeutler Matthew J. , McCarty Eric C. , Bravman Jonathan T. 
Published: October 2018

Background: Fixed- and adjustable-loop femoral cortical suspension devices are commonly used for femoral graft fixation during anterior cruciate ligament reconstruction (ACLR). Purpose: To compare the biomechanical results of fixed- versus adjustable-loop femoral cortical suspension devices in studies simulating ACLR with an isolated device and/or specimen setup using porcine femora and bovine flexor tendons. Study Design: Systematic review. Methods: Two independent reviewers searched PubMed, Embase, and the Cochrane Library databases to find studies comparing the biomechanical strength of fixed- and adjustable-loop cortical suspension devices for ACLR with isolated device and/or specimen setups using porcine femora and bovine flexor tendons. Studies that compared both devices with similar biomechanical methods were included. Data extracted included displacement during cyclic loading, ultimate load to failure, and mode of failure of the different cortical suspension devices for ACLR. Results: Six studies were identified that met the inclusion criteria, including a total of 76 fixed-loop devices and 120 adjustable-loop devices. Load to failure was significantly different ( P < .0001), with the strongest fixation device being the ToggleLoc with ZipLoop adjustable-loop device (1443.9 ± 512.3 N), compared with the Endobutton CL fixed-loop device (1312.9 ± 258.1 N; P = .04) and the TightRope RT adjustable-loop device (863.8 ± 64.7 N; P = .01). Cyclic displacement was significantly different, with Endobutton CL (3.7 ± 3.9 mm) showing the least displacement, followed by ToggleLoc with ZipLoop (4.9 ± 2.3 mm) and TightRope RT (7.7 ± 11.1 mm) ( P < .0001). Mode of failure was statistically different between the 3 groups ( P = .01), with suture failure accounting for 83.8% of TightRope RT devices, 69.4% of ToggleLoc with ZipLoop devices, and 60.3% of Endobutton CL devices. Conclusion: Current biomechanical data suggest that the ToggleLoc with ZipLoop device is the strongest fixation device at “time zero” in terms of ultimate load to mechanical failure. However, the Endobutton CL device demonstrated the least cyclic displacement, which may be a more clinically applicable measure of device superiority.
Complications After Tibial Tuberosity Osteotomy: Association With Screw Size and Concomitant Distalization
Authors: Johnson Alex A. , Wolfe Elizabeth L. , Mintz Douglas N. , Demehri Shadpour , Shubin Stein Beth E. , Cosgarea Andrew J. 
Published: October 2018

Background: Tibial tuberosity osteotomy (TTO) is a versatile procedure commonly used to treat patellar instability as well as to unload cartilage lesions. TTO with concomitant distalization (TTO-d) may be performed in patients with patella alta to stabilize the patella by helping it to engage in the trochlea earlier during flexion. Purpose: To identify and compare perioperative complications in patients who underwent TTO and those who underwent TTO-d and to analyze risk factors associated with these complications. Study Design: Cohort study; Level of evidence, 3. Methods: We retrospectively identified perioperative complications and associated factors from medical records for 240 patients who underwent TTO with or without distalization performed by 2 surgeons at 2 institutions between 2009 and 2015. A musculoskeletal radiologist at each institution determined osteotomy union using a published grading system. Significance was set at P < .01. Results: Of the 240 patients, 153 (122 TTO, 31 TTO-d) had clinical and radiographic follow-up of at least 90 days or evidence of osseous union. Eighty-eight complications were identified in 71 of 153 (46%) patients: delayed union (n = 35); painful hardware (n = 32); deep vein thrombosis (n = 4); clinical nonunion, delayed range of motion, sensory deficit, and wound breakdown (n = 3 each); and broken screw, fascial hernia, hematoma, quadriceps dysfunction, and tibial fracture (n = 1 each). Thirteen of 35 delayed unions occurred in the TTO-d group ( P = .005). Painful hardware was more frequent in patients who received 4.5-mm screws (31/115) than in those who received 3.5-mm screws (1/38) ( P = .001). A reoperation was required in 38 of 153 patients (37 patients using 4.5-mm screws vs 1 patient using 3.5-mm screws; P < .001), primarily for screw removal (32/38). Conclusion: Minor complications, including delayed union and painful hardware, were common, but major complications such as tibial fracture, deep vein thrombosis, and clinical nonunion were rare. Delayed union was more frequent in the TTO-d group. The 3.5-mm screws were less painful and less likely to need removal than the 4.5-mm screws.
Long-term safety of pirfenidone: results of the prospective, observational PASSPORT study
Authors: Cottin Vincent , Koschel Dirk , Günther Andreas , Albera Carlo , Azuma Arata , Sköld C. Magnus , Tomassetti Sara , Hormel Philip , Stauffer John L. , Strombom Indiana , Kirchgaessler Klaus-Uwe , Maher Toby M. 
Published: October 2018

Real-world studies include a broader patient population for a longer duration than randomised controlled trials (RCTs) and can provide relevant insights for clinical practice.PASSPORT was a multicentre, prospective, post-authorisation study of patients who were newly prescribed pirfenidone and followed for 2 years after initiating treatment. Physicians collected data on adverse drug reactions (ADRs), serious ADRs (SADRs) and ADRs of special interest (ADRSI) at baseline and then every 3 months.Post hocstepwise logistic regression models were used to identify baseline characteristics associated with discontinuing treatment due to an ADR.Patients (n=1009, 99.7% with idiopathic pulmonary fibrosis) had a median pirfenidone exposure of 442.0 days. Overall, 741 (73.4%) patients experienced ADRs, most commonly nausea (20.6%) and fatigue (18.5%). ADRs led to treatment discontinuation in 290 (28.7%) patients after a median of 99.5 days. Overall, 55 (5.5%) patients experienced SADRs, with a fatal outcome in six patients. ADRSI were reported in 693 patients, most commonly gastrointestinal symptoms (38.3%) and photosensitivity reactions/skin rashes (29.0%). Older age and female sex were associated with early treatment discontinuation due to an ADR.Findings were consistent with the known safety profile of pirfenidone, based on RCT data and other post-marketing experience, with no new safety signals observed.
User-elicited dual-hand interactions for manipulating 3D objects in virtual reality environments
Authors: Nanjappan Vijayakumar , Liang Hai-Ning , Lu Feiyu , Papangelis Konstantinos , Yue Yong , Man Ka Lok 
Published: October 2018

Abstract
Virtual reality technologies (VR) have advanced rapidly in the last few years. Prime examples include the Oculus RIFT and HTC Vive that are both head-worn/mounted displays (HMDs). VR HMDs enable a sense of immersion and allow enhanced natural interaction experiences with 3D objects. In this research we explore suitable interactions for manipulating 3D objects when users are wearing a VR HMD. In particular, this research focuses on a user-elicitation study to identify natural interactions for 3D manipulation using dual-hand controllers, which have become the standard input devices for VR HMDs. A user elicitation study requires potential users to provide interactions that are natural and intuitive based on given scenarios. The results of our study suggest that users prefer interactions that are based on shoulder motions (e.g., shoulder abduction and shoulder horizontal abduction) and elbow flexion movements. In addition, users seem to prefer one-hand interaction, and when two hands are required they prefer interactions that do not require simultaneous hand movements, but instead interactions that allow them to alternate between their hands. Results of our study are applicable to the design of dual-hand interactions with 3D objects in a variety of virtual reality environments.
Characterization of pigments and binders in a mural painting from the Andean church of San Andrés de Pachama (northernmost of Chile)
Authors: Tomasini Eugenia P. , Cárcamo José , Castellanos Rodríguez Diana M. , Careaga Valeria , Gutiérrez Sebastián , Rúa Landa Carlos , Sepúlveda Marcela , Guzman Fernando , Pereira Magdalena , Siracusano Gabriela , Maier Marta S. 
Published: October 2018

Abstract
The Andean church of San Andrés de Pachama is located in the highland of the northernmost of Chile, near the limit with Bolivia and next to the Ruta de la Plata. This commercial route contributed in the past to the transport and commerce of various raw materials, such as silver, from the Andean mountains region to the Pacific Ocean coast and then to the European market. The walls inside the church are decorated with paintings from the end of the eighteenth century that reproduce religious motivs together with flowers, fruits, and birds. In this study, micro samples taken from one of the mural paintings have been analysed to acquire information on the artistic materials and the painting technique previous to the restoration of the paintings. Analysis by micro-Raman spectroscopy complemented with scanning electron microscopy–energy dispersive X-ray spectroscopy, attenuated total reflection infrared spectroscopy, X-ray diffraction, and high-performance liquid chromatography with diode-array detection allowed the identification of orpiment, vermilion, indigo, smalt, antlerite, hematite, carmine lake, and wood charcoal as pigments as well as gypsum as the ground layer. Lipidic and proteinaceous materials extracted from the microsamples were identified by gas chromatography coupled to mass spectrometry and indicated the use of a mixture of egg and siccative oil as binders and a secco painting technique involving animal glue as the plaster primer. Smalt and the prized cochineal lake are reported for the first time in an Andean colonial mural painting.
IL‐2Rα up‐regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T‐cell lymphoma
Authors: Wang Liang , Bi Xi‐wen , Zhu Yu‐jia , He Ying‐zhi , Lai Qiu‐yu , Xia Zhong‐jun , Cai Qing‐qing 
Published: October 2018

AbstractBackgroundNatural killer/T‐cell lymphoma (NKTCL) is a highly aggressive non‐Hodgkin lymphoma often resistant to chemotherapy. Serum level of soluble IL‐2 receptor α (IL‐2Rα) is elevated in NKTCL patients and correlates significantly with treatment response and survival. In the current study we examined the potential role of IL‐2Rα by over‐expressing IL‐2Rα in representative cell lines.MethodsLevels of IL‐2Rα were evaluated in the human natural killer cell line NK‐92 and the NKTCL cell line SNK‐6. Lentiviral vectors were used to express latent membrane protein 1 (LMP1) in NK‐92 cells, and IL‐2Rα in both NK‐92 and SNK‐6 cells. The biological effects of these genes on proliferation, apoptosis, cell cycle distribution, and chemosensitivity were analyzed.ResultsExpression of IL‐2Rα was significantly higher in SNK‐6 cells than in NK‐92 cells. Expressing LMP1 in NK‐92 cells remarkably up‐regulated IL‐2Rα levels, whereas selective inhibitorss of the proteins in the MAPK/NF‐κB pathway significantly down‐regulated IL‐2Rα. IL‐2Rα overexpression in SNK‐6 cells promoted cell proliferation by altering cell cycle distribution, and induced resistance to gemcitabine, doxorubicin, and asparaginase. These effects were reversed by an anti‐IL‐2Rα antibody.ConclusionsOur results suggest that LMP1 activates the MAPK/NF‐κB pathway in NKTCL cells, up‐regulating IL‐2Rα expression. IL‐2Rα overexpression promotes growth and chemoresistance in NKTCL, making this interleukin receptor a potential therapeutic target.
Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing
Authors: Slavin Thomas P. , Banks Kimberly C. , Chudova Darya , Oxnard Geoffrey R. , Odegaard Justin I. , Nagy Rebecca J. , Tsang Kar Wing Kevin , Neuhausen Susan L. , Gray Stacy W. , Cristofanilli Massimo , Rodriguez Angel A. , Bardia Aditya , Leyland-Jones Brian , Janicek Mike F. , Lilly Michael , Sonpavde Guru , Lee Christine E. , Lanman Richard B. , Meric-Bernstam Funda , Kurzrock Razelle , Weitzel Jeffrey N. 
Published: October 2018

Purpose To determine the potential for detection of incidental germline cancer predisposition mutations through cell-free DNA (cfDNA) analyses in patients who underwent solid tumor somatic mutation evaluation. Patients and Methods Data were evaluated from 10,888 unselected patients with advanced (stage III/IV) cancer who underwent Guardant360 testing between November 2015 and December 2016. The main outcome was prevalence of putative germline mutations identified among 16 actionable hereditary cancer predisposition genes. Results More than 50 cancer types were studied, including lung (41%), breast (19%), colorectal (8%), prostate (6%), pancreatic (3%), and ovarian (2%). Average patient age was 63.5 years (range, 18 to 95 years); 43% were male. One hundred and fifty-six individuals (1.4%) had suspected hereditary cancer mutations in 11 genes. Putative germline mutations were more frequent in individuals younger than 50 years versus those 50 years and older (3.0% v 1.2%, respectively; P < .001). Highest yields of putative germline findings were in patients with ovarian (8.13%), prostate (3.46%), pancreatic (3.34%), and breast (2.2%) cancer. Putative germline mutation identification was consistent among 12 individuals with multiple samples. Patients with circulating tumor DNA copy number variation and/or reversion mutations suggestive of functional loss of the wild-type allele in the tumor DNA also are described. Conclusion Detection of putative germline mutations from cfDNA is feasible across multiple genes and cancer types without prior mutation knowledge. Many mutations were found in cancers without clear guidelines for hereditary cancer genetic counseling/testing. Given the clinical significance of identifying hereditary cancer predisposition for patients and their families as well as targetable germline alterations such as in BRCA1 or BRCA2, research on the best way to validate and return potential germline results from cfDNA analysis to clinicians and patients is needed.
Associations of Pre- and Postdiagnosis Diet Quality With Risk of Mortality Among Men and Women With Colorectal Cancer
Authors: Guinter Mark A. , McCullough Marjorie L. , Gapstur Susan M. , Campbell Peter T. 
Published: October 2018

Purpose Dietary patterns, indicators of overall diet quality, are associated with colorectal cancer (CRC) incidence but less consistently with mortality among CRC survivors. We prospectively evaluated associations of diet quality pre- and postdiagnosis with risk of mortality among men and women with CRC. Patients and Methods In the Cancer Prevention Study-II Nutrition Cohort, 2,801 participants were cancer free at baseline in 1992/1993 and subsequently diagnosed with invasive, nonmetastatic CRC during follow-up through June 2013. Pre- and postdiagnosis diet data were available for 2,671 and 1,321 participants, respectively, among whom 1,414 and 722 died. Concordance with the Dietary Approaches to Stop Hypertension (DASH), American Cancer Society nutrition guidelines (ACS-score), prudent, and Western dietary patterns was used to evaluate diet quality. Results Extreme scoring group comparisons showed that prediagnosis ACS-score was inversely associated with all-cause (hazard ratio high v low [HRHigh vLow], 0.78; 95% CI, 0.65 to 0.95) and CRC-specific (HRHigh vLow, 0.74; 95% CI, 0.54 to 1.03) mortality, whereas the Western diet score was associated with higher all-cause mortality (HRHigh vLow, 1.30; 95% CI, 1.03 to 1.64). For postdiagnosis diet, the ACS-score was associated with lower risk of all-cause (HRHigh vLow, 0.62; 95% CI, 0.47 to 0.83) and CRC-specific (HRHigh vLow, 0.35; 95% CI, 0.17 to 0.73) mortality, the DASH score was inversely associated with all-cause (HRHigh vLow, 0.79; 95% CI, 0.62 to 0.99) and CRC-specific (HRHigh vLow, 0.56; 95% CI, 0.35 to 0.89) mortality, and the prudent score was inversely associated with all-cause mortality (HRHigh vLow, 0.72; 95% CI, 0.56 to 0.93). Among participants with a low diet quality before diagnosis, improved DASH (HR, 0.54; 95% CI, 0.31 to 0.92) and prudent (HR, 0.53; 95% CI, 0.29 to 0.95) scores from pre- to postdiagnosis were inversely associated with CRC-specific mortality. Conclusion Dietary patterns reflective of high intakes of plant foods and low intakes of animal products before and after CRC diagnosis are associated with longer survival.
Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories
Authors: Dupont Cyr Bernard-Antonin , Dufresne France , Christen Felix , Desrosiers Véronique , Proulx Émilie , Le François Nathalie R. , Vandenberg Grant W. , Blier Pierre U. 
Published: October 2018

ABSTRACT
Hybridization between closely related species can generate genetic and phenotypic variation, providing valuable biological material to assess the physiological impact of the structural or functional variability of different organs. In the present study, we examined growth rates of various organs and whole body in brook char, Arctic char and their reciprocal hybrids over a period of 281 days. Parental species achieved significantly higher body mass than their hybrids. Hybridization significantly reduced the relative size of the heart, liver and spleen. The relative size of pyloric caeca did not differ among the four groups. The observed lower growth performance of the hybrids compared to parental species strongly suggests that divergence in the relative size of digestive organs, liver and heart partly dictate growth capacity. Our results also suggest that the increased variability achieved through hybridization may prove useful in a genetic selection program.
Functional proteomic profiling reveals KLK13 and TMPRSS11D as active proteases in the lower female reproductive tract
Authors: Muytjens Carla M.J. , Yu Yijing , Diamandis Eleftherios P. 
Published: October 2018

Background: Cervical-vaginal fluid (CVF) hydrates the mucosa of the lower female reproductive tract and is known to contain numerous proteases. The low pH of CVF (4.5 or below in healthy women of reproductive age) is a uniquely human attribute and poses a challenge for the proteolytic functioning of the proteases identified in this complex biological fluid. Despite the abundance of certain proteases in CVF, the proteolytic activity and function of proteases in CVF is not well characterized.Methods: In the present study, we employed fluorogenic substrate screening to investigate the influence of pH and inhibitory compounds on the proteolytic activity in CVF. Activity-based probe (ABP) proteomics has evolved as a powerful tool to investigate active proteases within complex proteomes and a trypsin-specific ABP was used to identify active proteases in CVF.Results: Serine proteases are among the most abundant proteins in the CVF proteome. Labeling human CVF samples with the trypsin-specific ABP revealed serine proteases transmembrane protein serine 11D and kallikrein-related peptidase 13 as active proteases in CVF. Furthermore, we demonstrated that the proteolytic activity in CVF is highly pH-dependent with an almost absolute inhibition of trypsin-like proteolytic activity at physiological pH levels.Conclusions: These findings provide a framework to understand proteolytic activity in CVF. Furthermore, the present results provide clues for a novel regulatory mechanism in which fluctuations in CVF pH have the potential to control the catalytic activity in the lower female reproductive tract.
FDTool: a Python application to mine for functional dependencies and candidate keys in tabular data
Authors: Buranosky Matt , Stellnberger Elmar , Pfaff Emily , Diaz-Sanchez David , Ward-Caviness Cavin 
Published: October 2018

Functional dependencies (FDs) and candidate keys are essential for table decomposition, database normalization, and data cleansing. In this paper, we present FDTool, a command line Python application to discover minimal FDs in tabular datasets and infer equivalent attribute sets and candidate keys from them. The runtime and memory costs associated with seven published FD discovery algorithms are given with an overview of their theoretical foundations. We conclude that FD_Mine is the most efficient FD discovery algorithm when applied to datasets with many rows (> 100,000 rows) and few columns (< 14 columns). This puts it in a special position to rule mine clinical and demographic datasets, which often consist of long and narrow sets of participant records. The structure of FD Mine is described and supplemented with a formal proof of the equivalence pruning method used. FDTool is a re-implementation of FD Mine with additional features added to improve performance and automate typical processes in database architecture. The experimental results of applying FDTool to 12 datasets of different dimensions are summarized in terms of the number of FDs checked, the number of FDs found, and the time it takes for the code to terminate. We find that the number of attributes in a dataset has a much greater effect on the runtime and memory costs of FDTool than does row count. The last section explains in detail how the FDTool application can be accessed, executed, and further developed.
Ambient and Indoor Air Pollution in Pregnancy and the risk of Low birth weight and Ensuing Effects in Infants (APPLE): A cohort study in Bangalore, South India
Authors: Shriyan Prafulla , Babu Giridhara R , Ravi Deepa , Ana Yamuna , van Schayck Onno CP , Thankachan Prashanth , Murthy GVS 
Published: October 2018

Background: Exposure to air pollution (IAP) from the combustion of solid fuels is a significant cause of morbidity and mortality in developing countries. Pregnant women exposed to higher pollutant levels are at higher risk of delivering a low-birth-weight (LBW) baby. There is a lack of standardized data regarding the levels and types of specific pollutants and how they impact LBW. We aim to prospectively assess the association between ambient and indoor air pollution levels in pregnancy and low birth weight and understand the subsequent risk of adiposity in these infants. Methods: We will conduct a prospective cohort study of 516 pregnant women recruited before 18 weeks of gestation in the urban slums of Bangalore, who have voluntarily consented to participate. We will estimate the level of air pollutants including coarse particulate matter 10 ug/m3 (PM10 ), fine particulate matter 2.5 ug/m3(PM2.5) and carbon monoxide (CO) parts per million (ppm) levels in both indoor and ambient environment. The follow-up of the delivered children will be done at delivery until the infant is two years old. The association between pollutants and LBW will be evaluated using logistic regression adjusting for potential confounders.Further, we will explore the mediation role of LBW in the hypothesized causal chain of air pollution and adiposity. Nested within a larger Maternal Antecedents of Adiposity and Studying the Transgenerational role of Hyperglycemia and Insulin (MAASTHI) cohort, we can estimate the absolute risk of having low birth weight caused by air pollution and other variables. Discussion: Understanding the association between exposures to ambient and indoor air pollution and low birth weight is essential in India. LBW babies have a higher risk of developing obesity and Non-Communicable Diseases (NCDs) during adulthood. The results from this study can inform the efforts for controlling the air pollution-related chronic diseases in India.