bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cold chain logistics performance: a framework
Authors: Chermala Ashok , Acharya Padmanav , Singh Rohit Kumar 
Published: November 2024

Purpose
Building a robust cold chain logistics system boosts the company’s profits in various ways. Any cold chain logistics company needs well-organised and efficient management of cold chain logistics to produce high-quality products, ensure that the product reaches the customer without any changes to the quality, and do so promptly. This paper aims to identify factors influencing cold chain logistics performance design. These factors are further helpful in analysing the behaviour intentions of stakeholders on increasing the cold chain logistic performance.

Design/methodology/approach
The authors conducted a thorough literature review to identify the variables that affect the performance of the cold chain logistics design. The factors were identified using exploratory factor analysis and empirically analysed using confirmatory factor analysis. The study also used structural equation modelling (SEM) to examine cold chain logistics performance determinants. Data was collected from 380 respondents working in the cold chain.

Findings
This study selected the factors influencing CCL performance, including five main factors and 22 sub-factors. Distribution, warehouse inventory storage, quality, demand, and technology affect the CCL’s performance. The results confirmed the theoretical model and proved that the factors significantly positively impact CCL performance.

Research limitations/implications
Future studies should focus on actual case studies to confirm the usefulness of the parameters found, examine how they affect performance growth, provide important insights into how to improve overall business performance and assist in identifying crucial research hotspots.

Practical implications
The study provides insight into issues regarding performance development in cold chain logistics for various stakeholders associated with the cold chain logistics industry, including practical managers, academics, and consultants. It also argues in favour of giving problems with CCL performance a higher priority. Policymakers interested in the service sector, like the Indian Department of Commerce and MSMEs, make up a modest additional audience for this work.

Social implications
Indian meat industry can be organised by implementing this methodology. This work benefits the government to get more transparent transaction and data digitalisation, which comes into account of GST.

Originality/value
There is a lack of significant quantitative literature suggesting modification strategies for factors affecting processed meat and chicken products in storage and transportation levels in India. Thus, this work tried to fill this gap and add the food chain logistics literature that helps practitioners and scholars enhance the food supply chain in developing countries.The framework developed for this study is where its originality lies. A detailed examination of cold chain logistics is included in the paper.
A novel strategy for simultaneous super‐resolution reconstruction and denoising of post‐stack seismic profile
Authors: Yu Wenshuo , Dong Shiqi , Lu Shaoping , Dong Xintong 
Published: November 2024

AbstractPost‐stack seismic profiles are images reflecting geological structures which provide a critical foundation for understanding the distribution of oil and gas resources. However, due to the limitations of seismic acquisition equipment and data collecting geometry, the post‐stack profiles suffer from low resolution and strong noise issues, which severely affects subsequent seismic interpretation. To better enhance the spatial resolution and signal‐to‐noise ratio of post‐seismic profiles, a multi‐scale attention encoder–decoder network based on generative adversarial network is proposed. This method improves the resolution of post‐stack profiles and effectively suppresses noises and recovers weak signals as well. A multi‐scale residual module is proposed to extract geological features under different receptive fields. At the same time, an attention module is designed to further guide the network to focus on important feature information. Additionally, to better recover the global and local information of post‐stack profiles, an adversarial network based on a Markov discriminator is proposed. Finally, by introducing an edge information preservation loss function, the conventional loss function of the Generative Adversarial Network is improved, which enables better recovery of the edge information of the original post‐stack profiles. Experimental results on simulated and field post‐stack profiles demonstrate that the proposed multi‐scale attention encoder–decoder network based on generative adversarial network method outperforms two advanced convolutional neural network‐based methods in noise suppression and weak signal recovery. Furthermore, the profiles reconstructed by the multi‐scale attention encoder–decoder network based on generative adversarial network method preserve more geological structures.
Phenotypic and Genomic Insights Into Bacillus spp. and Peribacillus spp. of Spanish Olive Groves With Biotechnological Potential
Authors: Manetsberger Julia , Gómez Natacha Caballero , Benomar Nabil , Christie Graham , Abriouel Hikmate 
Published: November 2024

ABSTRACTSpore‐forming organisms are an integral component of the rhizosphere, providing plants with significant advantages. Previous studies determined the antimicrobial activity of the olive sporobiota, identifying five candidates of particular relevance, belonging to the Bacillus subtilis, Peribacillus simplex and Bacillus cereus clade. This study aimed to determine their biotechnological properties, safety aspects, spore structure and resistance, and interaction with the environment through a combined microbiological and genomic approach. We report on the ability of these strains to produce hydrolytic and surface‐active enzymes and provide evidence for differences in population behaviour through the formation of strong sessile or floating biofilms. Electron microscopic analysis revealed for the first time the presence of an exosporium layer in olive sporobiota isolates belonging to the P. simplex and B. cereus clade, including numerous pili‐like structures on the latter. Spores showed significant differences in their resistance to wet heat, oxidising agents, and UV exposure. Whole genome sequencing of isolate Peribacillus frigoritolerans yielded information on its antimicrobial compound biosynthesis and environmental safety. Overall, our findings provide insights into the phenotypic, morphological and genetic variations of spore‐formers from Spanish olive groves, which can be useful for the development of bioactive compounds in sustainable agriculture.
Deciphering the enigma of human−lion coexistence in India
Authors: Gogoi Keshab , Banerjee Kausik , Chakrabarti Stotra , Singh Anirudh Pratap , Jhala Yadvendradev V. 
Published: November 2024

AbstractAsiatic lions (Panthera leo leo) have increased in range and abundance in densely populated India, a rare example of coexistence between humans and large carnivores. We sought to determine the underlying mechanisms of this coexistence and to infer lessons that could help conserve carnivores in multiuse landscapes, globally. Using data collected from 2012 to 2017 from conflict‐compensation records, we studied the spatiotemporal trends in human−lion conflict across the lion's range in India. We also surveyed 1434 people from 277 villages across the gradient of conflict to better understand their tolerance of lions. The cumulative number of villages that registered attacks on livestock increased by 105 (9.61%) per year, suggestive of an expanding lion population. Livestock killed per village increased by 15% per year, indicative of increasing lion density. Attacks on humans averaged 20.8 (SE 2.3) per year and showed no trend. Attacks on humans were spatially correlated with livestock predation, and both were best explained by proximity to lion tourism areas, lion habitat, and areas with low lion density. Intolerance of lions was related to economic losses (49.8%) and fear of lions (43.9%). Communities that lived longer with lions had higher probability of tolerating lions and practiced livestock‐rearing techniques that minimized predation. Human−lion coexistence is common in India as indicated by 61% of respondents being tolerant of lions. This coexistence is related to a mix of sociocultural tolerance, enforced legal protection, government compensation, and mutual adaptation of humans and lions to each other. Lions receive food subsidies from people and space, and local communities have enhanced livelihoods through tourism and bolstered sociocultural norms. Institutionalizing lion‐based ecotourism on community lands could support coexistence in the long term. Only through such participatory and profitable land‐sharing approaches can we best sync the well‐being of local communities with sustainable carnivore conservation.
Prognostic factors associated with worse outcomes following chemoradiation therapy in patients with anal carcinoma
Authors: Khurrum Muhammad , Cruz Alejandro , Schaub David , Gunderson Joseph , Moreno Andrea , Tecle Daniom , Gong Amanda , Assar Manijeh , Hargis McKenzie , Dooley Danielle Alexandra , Cruz Jose , Nfonsam Valentine 
Published: November 2024

AbstractAimChemoradiation therapy (CRT) is considered as the first line of treatment for patients with squamous cell carcinoma of the anal canal. Following initial CRT, patients who present with either persistent or locally recurrent disease are treated by surgical intervention. The aim of our study is to determine the prognostic factors associated with failure of CRT and overall mortality in patients with anal squamous cell carcinoma (SCC).MethodsWe performed a 14‐year analysis (2004–2017) of the National Cancer Database and included patients diagnosed with non‐metastatic SCC of the anal canal who underwent CRT. Baseline patient characteristics including demographics, comorbidities and tumour characteristics were analysed. Outcome measures were needed for operative intervention after 4 months of initiation of CRT (failure of CRT) and 5‐year overall mortality. Multivariate logistic regression analysis identified prognostic factors independently associated with failure of CRT.ResultsWe included a total of 37 615 patients with anal SCC who received CRT. Predictors of operative intervention included male sex, higher Deyo–Charlson Comorbidity Index (DCCI) and higher primary tumour stage. The 5‐year overall survival rate was 77.6%, and 2.4% of patients failed CRT, defined as requiring and undergoing surgical intervention within 4 months post‐initiation of CRT. Median follow‐up time was 47 (95% CI 24–84) months. Independent predictors of overall mortality within the first 5 years of diagnosis were increased age, male sex, Black race, non‐insured status, higher DCCI, higher primary tumour grade, and higher primary tumour and lymph node stage. The 5‐year survival rate was significantly lower in patients who underwent operative intervention compared to those who received CRT alone (57.4% vs. 78.1%; P < 0.01).ConclusionOur study showed that male sex, younger age, DCCI of 1 and 3, and increased tumour size were predictive of CRT failure among patients with anal SCC. Increased age, male sex, Black race, non‐insured status, increased DCCI, and more aggressive tumour characteristics were associated with increased 5‐year overall mortality. More importantly, patients who failed CRT had worse 5‐year overall survival. Our findings support increased emphasis on intensive surveillance for these high‐risk patient cohorts.
Repurposing metformin: A potential off‐label indication for ischaemic stroke?
Authors: Oo Thura Tun 
Published: November 2024

AbstractThe term ‘clinical cemetery’ is frequently used to characterize ischaemic stroke, one of the leading causes of mortality and long‐term morbidity globally. Over the past two decades, a number of novel therapies have been investigated for ischaemic stroke. However, aside from mechanical thrombectomy, the only FDA‐approved prescription for treating ischaemic stroke is tissue plasminogen activator, which has a limited therapeutic period. Although post‐stroke rehabilitation therapies are helpful in improving functional recovery, their benefits cannot be yielded promptly. Nowadays, drug repurposing might be an appealing approach to expanding therapeutic options for ischaemic stroke. During the last decade, metformin has been extensively researched as a potential repurposing medicine for ischaemic stroke, with a focus on both preventive and therapeutic approaches. With regard to the idea of repurposing metformin in ischaemic stroke, this review aims to compile the available data from pre‐clinical and clinical trials, address and clarify any discrepancies, and offer solutions.
Using Process Data to Evaluate the Impact of Shortening Allotted Case Time in a Simulation‐Based Assessment
Authors: Liu Chunyan , Cuddy Monica M. , He Qiwei , Ouyang Wenli , Artman Cara 
Published: November 2024

AbstractThe Computer‐based Case Simulations (CCS) component of the United States Medical Licensing Examination (USMLE) Step 3 was developed to assess the decision‐making and patient‐management skills of physicians. Process data can provide deep insights into examinees’ behavioral processes related to completing the CCS assessment task. In this paper, we utilized process data to evaluate the impact of shortening allotted time limit by rescoring the CCS cases based on process data extracted at various timestamps that represented different percentages of the original allotted case time. It was found that examinees’ performance as well as the correlation between original and newly generated scores both tended to decrease as the timestamp condition became stricter. The impact of shortening allotted time limit was found marginally associated with case difficulties, but strongly dependent on the case time intensity under the original time setting.
Atrial fibrillation in young stroke patients: Associated factors and outcomes in a nationwide analysis
Authors: Garrido‐Hernández Tania , Amaya‐Pascasio Laura , Quesada‐López Miguel , Arjona‐Padillo Antonio , García‐Torrecillas Juan Manuel , Martínez‐Sánchez Patricia 
Published: November 2024

AbstractBackground and purposeKnowledge about the prevalence of atrial fibrillation (AF) in young stroke patients, as well as its associated factors and outcomes, is scarce. Our objective was to analyse it.MethodsA retrospective analysis of the Spain Nationwide Minimum Basic Data Set (MBDS) (2016–2020), including ischaemic stroke (IS) patients aged 18 and 50 years, was conducted. Multivariate analyses were conducted to identify factors related to AF diagnosis.ResultsAmongst 11,615 young IS patients, 426 (3.7%) had AF. Patients with AF were older (median age 45, interquartile range 42–48 vs. 44, interquartile range 40–47 years, p < 0.001) and displayed more incapacitating symptoms, higher in‐hospital complications and were less often discharged home (p < 0.001). Multivariate analyses showed that older age (odds ratio [OR] 1.053, 95% confidence interval [CI] 1.032–1.074), obstructive sleep apnoea (OR 1.508, 95% CI 1.018–2.233), hyperthyroidism (OR 3.741, 95% CI 1.798–7.783), valvular heart disease (OR 6.094, 95% CI 4.261–8.716), congenital (OR 2.386, 95% CI 1.146–4.969) and non‐congenital (OR 4.446, 95% CI 3.149–6.278) cardiopathies and heart failure (OR 3.098, 95% CI 1.905–5.037) were independently associated with higher probability of AF, whereas female gender (OR 0.647, 95% CI 0.516–0.812), diabetes mellitus (0.487, 95% CI 0.339–0.699), smoking (OR 0.617, 95% CI 0.501–0.759), patent foramen ovale (OR 0.210, 95% CI 0.111–0.396) and arterial dissection (OR 0.294, 95% CI 0.130–0.668) were associated with a lower probability.ConclusionsIn young IS patients, AF is associated with more in‐hospital complications and disabling strokes. These findings emphasize the need to recognize AF in this demographic group, especially in patients with risk factors like hyperthyroidism and cardiomyopathies. Clinicians should assess these risk factors to ensure timely diagnosis and management of AF.
Real‐life experience with disease‐modifying drugs in hereditary transthyretin amyloid polyneuropathy: A clinical and electrophysiological appraisal
Authors: Rebouh Hadia , Verschueren Annie , Fortanier Etienne , Grapperon Aude‐Marie , Kouton Ludivine , Salort‐Campana Emmanuelle , Attarian Shahram , Delmont Emilien 
Published: November 2024

AbstractIntroductionNew treatments have dramatically improved the prognosis for Hereditary Transthyretin Amyloid Polyneuropathy (ATTRv‐PN). However, there is a lack of routine follow‐up studies outside of therapeutic trials. Our aim was to report the long‐term clinical and electrophysiological evolution of a cohort of ATTRv‐PN patients and to determine which biomarkers are most sensitive to change.MethodsWe retrospectively collected neuropathy impairment scale (NIS), polyneuropathy disability scale (PND), overall neuropathy limitation scale (ONLS), rash built overall disability scale (RODS), electrodiagnostic data, motor unit number index (MUNIX), troponin and N‐terminal pro‐brain natriuretic peptide levels. Electrophysiological worsening was defined as a 20% decrease in previous values.ResultsThirty‐five patients, with a median age of 58 (interquartile ranges 42–71) years, were followed for a median of 36 (24–48) months. All patients received a transthyretin stabiliser, gene silencer or liver transplant.Overall assessment of the cohort showed clinical, biological and electrophysiological stability. However, on an individual basis, NIS worsened in 45% of patients (14/31), ONLS in 46% (13/28), PND in 28% (9/32) and RODS in 39% (11/28) at the last follow‐up. Motor amplitude sum score decreased in 33% (11/33), amplitude recorded on tibialis anterior muscle in 44% (12/27), sensory amplitude sum score in 39% (11/28) and MUNIX sum score in 27% (7/26).ConclusionsOverall effectiveness of ATTRv‐PN treatments in routine care is good. However, individual assessments show up to 40% deterioration over time. Electrophysiological measures are valuable monitoring tools but are not more sensitive to change than clinical scores. Results must be confirmed in larger cohorts.
Association of early general anesthesia with outcome in adults with status epilepticus: A propensity‐matched observational study
Authors: Beuchat Isabelle , Novy Jan , Alvarez Vincent , Rosenow Felix , Kellinghaus Christoph , Rüegg Stephan , Tilz Christian , Trinka Eugen , Unterberger Iris , Uzelac Zeljko , Strzelczyk Adam , Rossetti Andrea O. 
Published: November 2024

AbstractGeneral anesthesia (GA) earlier than recommended (as first‐ or second‐line treatment) was recently described to improve status epilepticus (SE) outcome. We aimed to assess the impact of early GA on outcome in matched groups. Data from a multicenter, prospective cohort of 1179 SE episodes in 1049 adults were retrospectively analyzed. Incident SE episodes were categorized as “early anesthesia” (eGA; GA as first‐ or second‐line treatment) or “non‐early anesthesia” (neGA; GA after second‐line treatment or not at all). Using propensity score matching, eGA episodes were paired 1:4 with neGA episodes. We assessed survival, functional outcomes at discharge (good: modified Rankin Scale = 0–2 or no worsening), SE cessation rate, SE duration, and hospital stay. Among 1049 SE episodes, 55 (5.2%) received eGA, and 994 constituted the neGA group; 220 represented the matched controls. Patients receiving eGA were younger (median = 63, interquartile range [IQR] = 56–76 vs. median = 70, IQR = 54–80 years, p = .004), had deeper consciousness impairment (80% vs. 40% stuporous/comatose, p < .001), and had more severe SE forms (89% vs. 54% generalized convulsive SE/nonconvulsive SE in coma, p < .001). Mortality, functional outcome, SE cessation rate, and duration of SE and hospital stay were similar between the eGA group and matched controls. We conclude that early anesthesia for SE treatment did not influence prognosis.
Comparison of universal screening for gestational diabetes mellitus between one‐step and two‐step method among Thai pregnant women: A randomized control trial
Authors: Phoblap Natthaphon , Jatavan Phudit , Tongsong Theera 
Published: November 2024

ABSTRACTAimsTo compare the prevalence of GDM and pregnancy outcomes between the one‐step and two‐step methods of universal screening among Thai pregnant women.MethodsA randomized controlled trial was conducted on singleton Thai pregnant women at a gestational age of 24–28 weeks. They were randomly assigned to either the one‐step method group (a universal 75‐gm 2‐h oral glucose tolerance test: OGTT) or the two‐step method group (a universal 50‐gm oral glucose challenge test followed by a 100‐gm 3‐h OGTT). The women received standard antenatal care. The prevalence of GDM and obstetric outcomes were compared.ResultsA total of 143 women meeting the inclusion criteria were randomly allocated into the one‐step group (72 cases) and the two‐step group (71 cases). The prevalence of GDM was significantly higher in the one‐step group than in the two‐step group, with rates of 24/73 (33.3%) vs 8/70 (11.3%); P value 0.002; relative risk of 2.96, 95% CI: 1.43–6.14, respectively. Demographic data and maternal and neonatal outcomes were comparable between the two groups.ConclusionsThe one‐step method can markedly increase the prevalence of GDM to nearly three times that of the two‐step method, leading to a substantial increase in care costs and burdens without clear benefits. Convincingly, the one‐step method as a new approach may not be suitable for universal screening in a busy antenatal care setting, especially in low‐resource health centers in developing countries or among populations with a high prevalence of GDM.
Neuroendocrine tumors in the stomach: An epidemiological analysis of Belgian Cancer Registry data 2010–2019
Authors: Maly Marlies , Callebout Eduard , Ribeiro Suzane , Hoorens Anne , Carton Saskia , Cuyle Pieter‐Jan , Vandamme Timon , Borbath Ivan , Demetter Pieter , Van Damme Nancy , Van Eycken Liesbet , Verslype Chris , Geboes Karen 
Published: November 2024

AbstractThe prevalence of gastric NEN is estimated worldwide at 8.9% of all gastroenteropancreatic neuroendocrine neoplasm (GEP‐NEN) and only 0.3%–1% of all gastric neoplasms, but is rising in the last decades. The aim of this project was to map the epidemiology of gastric neuroendocrine neoplasm (gNEN) in Belgium. This is a population‐wide retrospective cohort study over 10 years (2010–2019), based on data from the Belgian Cancer Registry. A total of 641 patients were included; 605 patients with gNEN and 36 with MiNEN. The AAIR of gNEN was 0.67 per 100,000 person‐years, increasing over the years and with a slight female predominance (55.4%). Neuroendocrine carcinoma (NEC) accounted for 15.7% (N = 95), with an AAIR of 0.11 per 100,000 person‐years. The other 510 patients were diagnosed with gNET: G1 NET was most prevalent (54.3%) followed by G2 (32.5%) and G3 NET (3.5%). Concerning the clinical classification (type) of gNET, a diagnosis of type 1 tumors was presumed in 67.6%, type 3 tumors in 17.1% and type 2 tumors in 0.6% of patients. In only 3.8% of patients, the clinical classification was explicitly stated in the pathology report. Stage IV tumors were diagnosed in 13.4% (N = 81). A favorable evolution in pathology reporting is seen. Some variables—for example, clinical classification of gNET—were heavily underreported, stressing the importance of registries integrating clinical and pathological information.