bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of gene therapy for sensorineural hearing loss in mouse model: A meta‐analysis
Authors: Yilmaz Nevra Keskin , Ozen Dogukan , da Costa Monsanto Rafael , Ocak Emre , Schuster Artur Koerig , Shimura Tomotaka , Cureoglu Sebahattin 
Published: December 2024

AbstractObjectivesSensorineural hearing loss (SNHL) is a disorder characterized by the loss or impairment of cochlear hair cells or the auditory nerve. In recent years, gene therapy has emerged as a promising approach for SNHL treatment. The objective of this study is to evaluate the impact of gene therapy on the restoration or improvement of auditory function in mouse model with loss or impairment of hearing.MethodsStudies with clear experimental designs, and auditory brainstem response (ABR) analysis as relevant outcome measures were included by searching PubMed, Scopus, and Web of Science databases. The PRISMA guideline was used for abstracting data and assessing data quality and validity. A quantitative synthesis was performed using a random effects model to examine the effect of gene therapy on auditory function in SNHL.ResultsNine articles including 71 studies meeting the inclusion criteria were identified. These studies explored therapies targeting the TMC1, VGLUT3, USH1C, CLRN1, WHRN, and PJVK genes, with genetic material ranging from 1.8 × 1011 and 1.4 × 1014 gc/mL being delivered to the inner ear through round window membrane, cochleostomy, or posterior semicircular canal injection methods. The hearing test results showed a significant mean difference of 26.91 dB (95% CI: 22.01–31.85) in favor of the experimental group.ConclusionsAlthough promising results have been obtained regarding the potential success of gene therapy in SNHL, further investigation is needed to explore the long‐term effects of gene therapy, treatment response rates, and the relationships between different genetic mutation types.
Mid‐Infrared on‐Chip Soliton Self‐frequency Shift in Chalcogenide Glass Waveguide
Authors: Yang Lei , Wei Zibo , Xia Kai , Yang Zhen , Wang Haoxian , Yang Peilong , Zhang Wei , Wang Rongping , Dai Shixun , Gan Fuwan , Kang Zhe , Xu Peipeng 
Published: December 2024

AbstractMid‐infrared soliton lasers leveraging the Raman self‐pumping induced soliton self‐frequency shift (SSFS) effect offer continuously tunable, highly efficient, femtosecond coherent sources that are essential for applications such as spectroscopy, metrology, and quantum optics. However, despite significant advancements in fluoride and chalcogenide fiber platforms, realizing mid‐infrared Raman soliton lasers on on‐chip platforms remains challenging. In this study, the first experimental demonstration of a mid‐infrared Raman soliton laser in an on‐chip Ge28Sb12Se60 (GeSbSe) chalcogenide glass waveguide is presented. A fully fiberized femtosecond fiber laser, centered at 1.96 µm and emitting 246 fs pulses at a 50 MHz repetition rate, is utilized as the pump source, establishing a fiber‐to‐chip configuration. The waveguides are meticulously fabricated using e‐beam lithography and plasma etching, achieving high optical quality and precision in the mid‐infrared regime. Through precise geometrical dispersion engineering, a Raman soliton laser is achieved that continuously tunes from 1960 to 2145 nm within a 32.5 mm long snakelike GeSbSe strip waveguide. The threshold for pump peak power is remarkably low, at just 14.1 W (3.47 pJ). Additionally, a more than one‐octave‐spanning near to mid‐infrared supercontinuum (1320–2760 nm at 22.9 pJ), reinforced by the combined Kerr and Raman effects, is also realized, confirming the versatile performance of the proposed GeSbSe waveguide. These findings pave the way for mid‐infrared on‐chip Raman soliton lasers, highlighting their potential for power‐efficient, low‐cost, and field‐deployable on‐chip applications in the mid‐infrared regime.
When Did They Post It? How Temporal Markers Influence the Persuasiveness of Online Reviews
Authors: Hagen Linda , O'Brien Ed 
Published: December 2024

ABSTRACTBefore buying a product, consumers often seek the opinions of others who have past experience with it, for example, by browsing online reviews. This research finds that the persuasive impact of such reviews depends on their temporal context: Consumers view the same review as less persuasive when tagged with proximate temporal markers (e.g., “Bought this one day ago”) versus distant temporal markers (e.g., “Bought this one year ago”). This happens because consumers infer from temporal markers that the reviewer must be (in)sufficiently experienced. These effects emerged both in the field (Experiment 1) and in controlled contexts using varied products (Experiments 2a, 2b) and across valence, such that proximate temporal markers undermined recommendations from positive reviews but also softened criticisms from negative reviews (Experiments 3, 4a,b). Accordingly, the effects were moderated by conditions that restored perceptions of the reviewer's experience in other ways beyond time (Experiments 5–7). Together, these findings highlight how consumers draw reviewer inferences from temporal markers in reviews, which bear on the review's persuasiveness. The undermining impact of proximate temporal markers may be increasingly relevant in today's online review landscape, where speedy reviews have become the expected norm. Temporal markers may wield unintended effects on review persuasion, holding the review constant.
Cerebral vascular malformations: pathogenesis and therapy
Authors: He Qiheng , Huo Ran , Sun Yingfan , Zheng Zhiyao , Xu Hongyuan , Zhao Shaozhi , Ni Yang , Yu Qifeng , Jiao Yuming , Zhang Wenqian , Zhao Jizong , Cao Yong 
Published: December 2024

AbstractCerebral vascular malformations (CVMs), particularly cerebral cavernous malformations and cerebral arteriovenous malformations, pose significant neurological challenges due to their complex etiologies and clinical implications. Traditionally viewed as congenital conditions with structural abnormalities, CVMs have been treated primarily through resection, embolization, and stereotactic radiosurgery. While these approaches offer some efficacy, they often pose risks to neurological integrity due to their invasive nature. Advances in next‐generation sequencing, particularly high‐depth whole‐exome sequencing and bioinformatics, have facilitated the identification of gene variants from neurosurgically resected CVMs samples. These advancements have deepened our understanding of CVM pathogenesis. Somatic mutations in key mechanistic pathways have been identified as causative factors, leading to a paradigm shift in CVM treatment. Additionally, recent progress in noninvasive and minimally invasive techniques, including gene imaging genomics, liquid biopsy, or endovascular biopsies (endovascular sampling of blood vessel lumens), has enabled the identification of gene variants associated with CVMs. These methods, in conjunction with clinical data, offer potential for early detection, dynamic monitoring, and targeted therapies that could be used as monotherapy or adjuncts to surgery. This review highlights advancements in CVM pathogenesis and precision therapies, outlining the future potential of precision medicine in CVM management.
Ionospheric clutter reduction for high‐frequency surface‐wave radar based on time‐frequency‐ridgelet filtering
Authors: Su Yuan , Wei Yinsheng , Xu Rongqing , Liu Yongtan 
Published: December 2024

AbstractThe existence of ionosphere clutter, the target limits the performance of high frequency surface wave radar (HFSWR). It is more desirable to solve the problem of ionosphere clutter mitigation. Existing methods suffer difficulty when the clutter is nonstationary. To overcome this issue, a novel ionospheric clutter mitigation algorithm based on Time‐Frequency‐Ridgelet Filtering (TFRF) is proposed in this paper. Our study shows that the time‐frequency ridgelet coefficients of the clutter are nonstationary, whereas the targets' are stationary. Therefore, the ionosphere clutter can be reduced by the TFRF method. Experimental results show that the proposed TFRF method can effectively mitigate the nonstationary ionospheric clutter, and can improve the Signal to Clutter and Noise Ratio and the detection performance of HFSWR.
A flexible framework for the design and optimization of water‐excitation RF pulses using B‐spline interpolation
Authors: Sieber Xavier , Romanin Ludovica , Bastiaansen Jessica A. M. , Roy Christopher W. , Yerly Jérôme , Wenz Daniel , Richiardi Jonas , Stuber Matthias , van Heeswijk Ruud B. 
Published: December 2024

AbstractPurposeTo implement a flexible framework, named HydrOptiFrame, for the design and optimization of time‐efficient water‐excitation (WE) RF pulses using B‐spline interpolation, and to characterize their lipid suppression performance.MethodsAn evolutionary optimization algorithm was used to design WE RF pulses. The algorithm minimizes a composite loss function that quantifies the fat–water contrast using Bloch equation simulations. In a first study, B‐spline interpolated optimized (BSIO) pulses designed with HydrOptiFrame with durations of 1 and 0.76 ms were generated for 3 T and characterized in healthy volunteers' knees. The femoral bone marrow SNR was compared to that obtained with to 1–1 WE and lipid insensitive binomial off resonant excitation (LIBRE) pulses. In a second study, in the heart at 1.5 T, the water–fat contrast ratio and coronary artery vessel length obtained with a 2.56 ms BSIO pulse was compared to 1–1 WE and LIBRE pulses in free‐running cardiovascular MR.ResultsThe 1 ms BSIO pulse resulted in higher fat suppression and lower contrast ratio (CR) in the bone marrow than the state‐of‐the‐art pulses (4.1 ± 0.2 vs. 4.7 ± 0.4 and 4.4 ± 0.3 for the BSIO, the 1–1 WE and LIBRE respectively, p < 0.05 vs. both) at 3 T. At 1.5 T, the BSIO pulse resulted in a higher blood‐epicardial fat CR (3.8 ± 1.3 vs. 1.6 ± 0.6 and 2.4 ± 1.1 for the BSIO, 1–1 WE and LIBRE, respectively, p < 0.05 vs. both) and longer traceable left coronary artery vessel length (8.7 ± 1.4 cm vs. 7.0 ± 1.0 cm [p = 0.04] and 7.5 ± 1.2 cm [p = 0.09]).ConclusionThe HydrOptiFrame framework offers a new opportunity to design WE RF pulses that are robust to B0 inhomogeneity at multiple magnetic field strengths and for variable RF pulse durations.
Bone Health Determinants in Ambulant Prepubertal Boys With Duchenne Muscular Dystrophy Treated With Deflazacort: Findings From a 3‐Year Study
Authors: Panicucci Chiara , Casalini Sara , Angelelli Alessia , Brolatti Noemi , Pedemonte Marina , Patti Giuseppa , Maghnie Mohamad , Bruno Claudio , Di Iorgi Natascia 
Published: December 2024

ABSTRACTIntroduction/AimsDuchenne muscular dystrophy (DMD) is complicated by bone fragility. This study aimed to elucidate changes in bone mineral density (BMD) and body composition over time and to explore associations with adiposity measures in DMD.MethodsA three‐year follow‐up analysis was performed of total body (TB) and lumbar spine (LS) dual‐energy x‐ray absorptiometry (DXA) measurements, anthropometric measures, Tanner stage and bone turnover biomarkers assessments, and the incidence of fragility fractures in 26 ambulant prepubertal DMD patients treated with deflazacort (DFZ).ResultsAge at baseline was 7.7 years (interquartile range: 6–9.2). The TB BMD Z‐score declined over time and was negatively related to the TB fat mass percentage and fat mass index (p < 0.05), but not to body mass index (BMI) standard deviation score (SDS). In contrast LS bone mineral apparent density (BMAD) Z‐score remained stable and normal. The cumulative incidence of fragility fractures was 19.2%; DMD boys with fractures displayed a 1.5‐fold higher decline of TB BMD Z‐score/year (p < 0.05) and a worse adiposity profile compared to fracture‐free patients. No difference was found in DFZ dose or duration between the two groups.DiscussionWe observed a high incidence of fragility fractures, and identified fat tissue as a potential detrimental factor for bone health, suggesting a need for monitoring in DMD patients with excessive adiposity. Fat mass measures assessed by DXA could help to identify those at risk, enabling targeted interventions for better bone health. The co‐occurrence of multiple glucocorticoid side effects might characterize patients at higher risk of fractures.
Prevalence of Urinary Incontinence and Its Association With Neurodevelopmental Disorders Among Children in Japan
Authors: Watanabe Yoshitaka , Ikeda Hirokazu , Ono Takahiro , Oyake Chisato , Endo Shota , Onuki Yuta , Fuyama Masaki , Watanabe Tsuneki 
Published: December 2024

ABSTRACTAimTo investigate urinary incontinence prevalence and its association with neurodevelopmental disorders among children in Japan.MethodsA web‐based survey was conducted on children aged 5–15 years in Japan. Information on daytime and nocturnal incontinence and neurodevelopmental disorders, such as attention deficit hyperactivity disorder, autism spectrum disorder, and intellectual disability, was collected.ResultsResponses from 5186 questionnaires (2619 boys, 2517 girls) were evaluated. In total, 505 children had neurodevelopmental disorders. Furthermore, 148 children had daytime urinary incontinence. The incidence of daytime urinary incontinence did not differ significantly according to sex. Daytime urinary incontinence was associated with neurodevelopmental disorders in 33.1% of children. Moreover, 220 children had nocturnal enuresis. Boys had a significantly higher prevalence of nocturnal enuresis than girls in the overall cohort and early elementary school age group. Nocturnal enuresis was associated with neurodevelopmental disorders in 29.1% of children. Children with daytime urinary incontinence or nocturnal enuresis had a significantly higher incidence of neurodevelopmental disorders.ConclusionsThe prevalence of concomitant daytime and nocturnal urinary incontinence and neurodevelopmental disorders in children is significant.
Trajectory Planning With A* Algorithm and Tracking With Multiple Controllers
Authors: Yiğit Sinan , Sezgin Aziz 
Published: December 2024

ABSTRACTThis article consists of mathematical modelling of differential drive mobile robot (DDMR), path planning and tracking application via multiple controller usage. Robot kinematic and dynamic models were constructed and simulated in virtual 2D map environment. A* algorithm was applied to the 2D map problem to acquire optimal pathfinding, efficiency and flexibility in trajectory planning stage. After the reference trajectory is obtained by algorithm, the robot needs to be guided using control strategy that manages the speed control of electric motors. At the first part of the control problem, kinematic based backstepping control (KBBC) were used to increase the efficiency of the control system. After that Sliding Mode Control (SMC) and Proportional‐Integral‐Derivative (PID) control strategies were applied to reduce tracking errors between reference and actual coordinate values and heading angle value. To test the robustness and efficiency of control combinations, two different simulation systems were designed using Matlab‐Simulink Software. First system was designed for the non‐disturbance condition, while the second system included disturbance torque and an additional mass applied condition. Test results showcasing the performance of the controllers are presented in the concluding section, through trajectory tracking and error comparison graphs.
Validation and Application of Functions of Future Thinking Scale in Chinese Adults
Authors: Liu Lulu , Dai Lijuan , Wang Ya 
Published: December 2024

ABSTRACTFuture thinking, mentally projecting oneself into future events, scenarios, and circumstances, is common in everyday life. However, no scale has been developed to explore the functions of future thinking in China. This study aimed to validate the Chinese version of the functions of future thinking scale (FoFTS). Based on a sample of 578 Chinese residents, confirmatory factor analysis results indicated that the 10‐factor structure of the Chinese version of FoFTS fit well. The reliability indexes across 10 factors were in an acceptable range. Acceptable convergent validity was reported considering its association with time perspective, future self‐continuity, emotion regulation, and intertemporal decision‐making. Additionally, the effect of age and the severity of emotional states on FoFTS were found. Overall, the Chinese FoFTS is a reliable and valid tool for examining the diverse purposes and roles of future thinking among Chinese adults, thereby enhancing the cross‐cultural study of purposes for future thinking.
Computationally aided design of single‐ion‐conducting block copolymer electrolytes to boost lithium‐ion conductivity
Authors: Song Zi‐Chen , Ma Xiao‐Juan , Huang Chong‐Yang , Xu Fei‐Xiang , Fang Shang‐Quan , Peng Ze‐Xin , Zhang Rui 
Published: December 2024

AbstractIn this work, we implement a combinatory approach that integrates molecular dynamics (MD) simulation and a Gaussian process regression (GPR) algorithm to explore optimal design strategies for a generic single‐ion‐conducting block copolymer electrolyte (SIC‐BCPE) model system that covers a rich design parameter space inspired by recently established poly(ethylene oxide)‐based block copolymer electrolytes. The GPR algorithm is employed to efficiently reveal the relationships between the desired lithium‐ion conductivity and four design parameters reflecting both chain architectural control and specific tuning of molecular chemistry. Guided by the GPR results, an optimal combination of four parameter values is inferred, and MD simulation confirms that the corresponding SIC‐BCPE system produces relatively higher lithium‐ion conductivity. To further understand the influence of each molecular parameter on the trends of lithium‐ion conductivity, we analyse the proportion variation of different types of lithium‐ion coordination and identify a strong correlation between the ion coordination pattern and ionic conductivity. Due to its generality, we expect that the MD‐GPR combinatory approach reported in this work is applicable to a broad range of other polymer‐based ion transport systems. © 2024 Society of Chemical Industry.
Enzymatic Degradation of Poly(Butylene Adipate‐co‐Terephthalate)/Poly(Lactic Acid) Blends
Authors: Benninga Joël , Lima Guilherme Macedo R. , Érsek Gábor , Portale Giuseppe , Folkersma Rudy , Voet Vincent S. D. , Loos Katja 
Published: December 2024

ABSTRACTPoly(lactic acid) (PLA) is regularly blended with poly(butylene adipate‐co‐terephthalate) (PBAT) to produce compostable plastic films used in packaging applications, for example. Since PLA and PBAT both contain ester bonds, these PBAT/PLA blends are interesting candidates for enzymatic recycling. This is a new, green recycling technique that allows the use of mild processing conditions to regenerate the pure building blocks of polymers, thereby enabling repolymerization to virgin‐quality plastic. In this work, various PBAT/PLA blends are prepared (20, 40, 60, and 80 wt% PBAT) and incubated with a cutinase enzyme from Humicola insolens (HiC). Enzymatic degradation is characterized by weight loss, scanning electron microscopy (SEM), and proton nuclear magnetic resonance (1H NMR) spectroscopy. Blends rich in PBAT are effectively degraded by HiC (up to 40% weight loss after 7 days of incubation at 70°C), while PLA‐rich blends are degraded to a lesser extent. HiC is capable of degrading both polymers, although for PLA, the extent of degradation is similar to control experiments without HiC. Furthermore, in the absence of an enzyme, a “shielding” effect is found for nonenzymatic degradation, where a hydrolytically stable PBAT matrix prevents the degradation of the PLA domains. This work provides insight into the enzymatic degradation of uncompatibilized polymer blends and opens up the possibility for the enzymatic recycling of commercial PBAT/PLA blends.
Free‐Radical Polymerization of Liquid Hydroxyethyl Methacrylate Layers Using Nanosecond Plasma Pulses
Authors: Azevedo Gonçalves Ingrid , Abessolo Ondo Dominique , Boscher Nicolas D. , Quintana Robert 
Published: December 2024

ABSTRACTPromoting both high functional group preservation and high deposition rates is a major challenge in plasma deposition. This study explores a dynamic method using nanosecond pulsed plasma discharges to polymerize thin liquid layers of 2‐hydroxyethyl methacrylate (HEMA). The influence of plasma pulse frequency (200 ns) and liquid layer thickness on chemical structure retention, polymeric growth, and thin film growth rate is examined. High‐resolution mass spectrometry (HRMS) highlights that plasma curing of liquid monomer layers achieves significantly better chemical structure preservation and polymeric growth, along with deposition rates an order of magnitude higher than traditional vapour‐phase methods. This work provides valuable insights and guidelines for plasma‐induced free‐radical polymerization of liquid layers into functional thin solid films.
Terroir and rootstock effects on leaf shape in California Central Valley vineyards
Authors: Migicovsky Zoë , Swift Joel F. , Awale Mani , Helget Zachary , Klein Laura L. , Pinkner Leah , Woodhouse Karoline , Cousins Peter , Fennell Anne Y. , Miller Allison J. , Chitwood Daniel H. 
Published: December 2024

Societal Impact StatementThe innumerable effects of terroir—including climate, soil, microbial environment, biotic interactions, and cultivation practice—collectively alter plant performance and production. A more direct agricultural intervention is grafting, in which genetically distinct shoot and root genotypes are surgically combined to create a chimera that alters shoot performance at a distance. Selection of location and rootstock are intentional decisions in viticulture to positively alter production outcomes. Here, we show that terroir and rootstock alter the shapes of grapevine leaves in commercial vineyards throughout the California Central Valley, documenting the profound effects of these agricultural interventions that alter plant morphology.Summary
Embedded in a single leaf shape are the latent signatures of genetic, developmental, and environmental effects. In viticulture, choice of location and rootstock are important decisions that affect the performance and production of the shoot. We hypothesize that these effects influence plant morphology, as reflected in leaf shape.
We sample 1879 leaves arising from scion and rootstock combinations from commercial vineyards in the Central Valley of California. Our design tests 20 pairwise contrasts between Cabernet Sauvignon and Chardonnay scions from San Joaquin, Merced, and Madera counties from vines grafted to Teleki 5C, 1103 Paulsen, and Freedom rootstocks.
We quantify clear differences between Cabernet Sauvignon and Chardonnay leaves. However, we also detect a separate, statistically independent source of shape variance that affects both Cabernet Sauvignon and Chardonnay leaves similarly. We find that this other shape difference is associated with differences in rootstock and location.
The shape difference that arises from rootstock and location affects the basal part of the leaf near the petiole, known as the petiolar sinus, and affects its closure. This shape effect is independent from previously described shape differences that arise from genetic, developmental, or size effects.