bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance P enhances the local activation of NK1R-expressing c-Kit+ cardiac progenitor cells in right atrium of ischemia/reperfusion-injured heart
Authors: Jeong YunMi , Cheng Xian Wu , Lee KyungHye , LEE SORA , Cho Haneul , Kim Weon 
Published: August 2019

Abstract
Background: Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R signal pathways in the RA remains unclear. Sprague-Dawley rats were randomly divided into 4 groups (n=22 each); subjected to sham, ischemia/reperfusion-injury (I/R), I/R with 5 nmole/kg SP injection (SP+I/R), and SP+I/R with 1 mg/kg RP67580 injection (RP, a selective non-peptide tachykinin NK1R antagonist) (RP/SP+I/R). The left anterior descending coronary artery was occluded for 40 min followed by 1 day reperfusion with SP or SP+RP or without either. After 1 day, both atria and ventricles as well as the heart apexes were collected. Results: SP promoted the expression of c-Kit, GATA4, Oct4, Nanog, and Sox2 in only the RA of the SP+I/R rats via NK1R activation. In agreement with these observations, NK1R-expressing c-Kit+ Nkx2.5+GATA4+ cardiac progenitor cells (CPCs) in the ex vivo RA explant outgrowth assay markedly migrated out from RA1 day SP+I/R approximately 2-fold increase more than RA1 day I/R. Treatment of SP promoted proliferation, migration, cardiosphere formation, and potential to differentiate into cardiomyocytes. Using RP inhibitor, NK1R antagonist not only inhibited cell proliferation and migration but also reduced the formation of cardiosphere and differentiation of c-Kit+ CPCs Conclusion: SP/NK1R might play a role as a key mediator involved in the cellular response to c-Kit+ CPC expansion in RA of the heart within 24 h after I/R.
Size of bone flap in decompressive craniectomy: an analysis of complications and prognosis in traumatic brain injury
Authors: Xu Min , Luo Yu , Yi Pan , Wang Cunzu 
Published: August 2019

Abstract
Objective: To investigate association of size of bone flap with common complications and prognosis in traumatic brain injury. Methods: A retrospective analysis was performed in 108 TBI patients of Northern Jiangsu People's Hospital from January 2018 to March 2019. Patients’ gender, age, Glasgow Coma Scale at admisson, pupils reactivity to the light, size of bone flap, types of craniocerebral injuries and injury locations were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Prognostic indicators including Glasgow Outcome Scale scores at discharge and GOS scores of 6 months after operation were extracted to evaluate surgical effcacy.Results : Postoperative complications such as encephalocele and subdural effusion were significantly associated with size of bone flap ( P <0.05). The incidence of encephalocele and SE increased with bone flap size in bone flap groups. Age, GCS at admisson, pupils reactivity to the light, and size of bone flap were shown significantly differences between prognosis groups ( P <0.05). By binary logistic regression, Age, pupils reactivity to the light, and the size of bone flap showed statistical significance ( P <0.05). Conclusion: Size of bone flap in decompressive craniectomy is a dependent factor to prognosis. Avoiding oversize craniectomy may bring less complications and positive prognosis.
Segmenting OCT for Detecting Drug Efficacy in CRAO
Authors: Shearer Thomas Robert , Hwang Thomas S , Steinkamp Peter N , Azuma Mitsuyoshi 
Published: August 2019

Abstract
Thinning of the inner layers of the retina occurs in patients with central retinal artery occlusion (CRAO). The mechanism for such thinning may be partially due to proteolysis by a calcium-activated protease called calpain. Calpain inhibitor SNJ-1945 ameliorated the proteolysis in a past series of model experiments. The purposes of the present retrospective study were to: 1) use segmentation analysis of optical coherence tomography (OCT) images to mathematically model the loss of specific retinal layers in CRAO patients, and 2) predict the number of patients and days of observation needed for clinical trials of SNJ-1945 inhibitor against CRAO.
Supercapsular percutaneously-assisted total hip (SuperPath) versus posterolateral total hip arthroplasty in bilateral osteonecrosis of the femoral head: a pilot clinical trial
Authors: Meng Weikun , Huang Zhong , Wang Haoyang , Wang Duan , Luo Zeyu , Bai Yang , Gao Liang , Wang Guanglin , Zhou Zongke 
Published: August 2019

Abstract
Background: The supercapsular percutaneously-assisted total hip arthroplasty (SuperPath) was proposed to be minimally invasive and tissue sparing with possible superior postoperative outcomes to traditional approaches of total hip arthroplasty (THA). Here, we compared the short-term outcomes of staged THA with the SuperPath or through posterolateral approach (PLA) for bilateral osteonecrosis of the femoral head (ONFH). Methods: Patients with bilateral late-stage ONFH were prospectively recruited from our department during March 2017 to March 2018. Staged bilateral THAs with one side SuperPath and the other side PLA were performed consecutively in the same patients with right and left hips alternating within groups. The average time interval between the staged THAs was 3 months. Perioperative status (operation time, incision length, intraoperative blood loss, soft tissue damage, and length of hospital stay) and postoperative function (range of motion, pain, and hip function) were recorded and compared between the SuperPath and PLA groups within 12-month postoperatively. Results: Four male patients (age, 51.00 ± 4.54; BMI, 21.49 ± 1.73) with bilateral alcohol-induced ONFH (Ficat III/IV) were followed up over 12 months postoperatively. Compared with the PLA, the SuperPath yielded significantly shorter incision length (7.62 vs. 11.12 cm, P = 0.049), longer operation time (103.25 vs. 66.50 min, P = 0.034), more blood loss (1108.50 vs. 843.50 ml, P = 0.023), deficient acetabular cup positioning (abduction angle, 38.75° vs. 44.50°, P = 0.035), and inferior early-term hip function (Harris hip score, 72.50 vs. 83.25, P = 0.025) at 12-month postoperatively. However, soft tissue damage, length of hospital stay, postoperative pain, postoperative range of motion, and 12-month patient satisfaction were comparable between both groups. Conclusions: The SuperPath might not be truly minimal invasive with advantages over the PLA for total hip arthroplasty in osteonecrosis of the femoral head. More investigations are required to provide convincing favorable evidences of the SuperPath over other traditional THA approaches.
The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study
Authors: Tang Lizhi , Tong Yuzhen , Zhang Fang , Chen Guilin , Zhang Yun Cong , Jobin John , Tong Nanwei 
Published: August 2019

Abstract
Background

Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population.Methods

The study was based on cross-sectional analysis of data from 524 nondiabetic subjects aged 40~65. All participants were recruited from a screening survey for Metabolic Syndrome in a community in Southwest China, including 294 subjects categorized as overweight (defined as BMI≧25 kg/m 2 ) and 230 subjects as normal control (defined as 18.5≦BMI<25 kg/m 2 ). Serum irisin concentration was quantified by enzyme linked immunosorbent assay (ELISA). The relationship of irisin with metabolic factors was determined by Pearson correlation. Multivariate linear regression was used to analyze the association of irisin with insulin resistance. Logistic regression was performed to assess the association of irisin with odds of overweight.Results

Serum irisin levels were significantly lower in nondiabetic overweight subjects compared with control (11.46±4.11vs14.78±7.03µg/mL, p=0.02). Circulating irisin was positively correlated with quantitative insulin sensitivity check index (QUICKI, r=0.178, p=0.045) and triglycerides (r=0.149, p=0.022); while irisin was negatively correlated with waist circumference (WC, r=-0.185, p=0.037), waist-to-hip ratio (WHR, r=-0.176, p=0.047), fasting insulin (r=-0.2, p=0.024), serum creatinine (r=-0.243, p=0.006), homeostasis model assessment for insulin resistance (HOMA-IR, r=-0.189, p=0.033). Multiple linear regression showed that irisin was inversely associated with HOMA-IR (β=-0.342±0.154, p=0.029). Higher irisin was associated with decreased odds of being overweight (OR=0.281, β=-1.271, p=0.024).Conclusions

We found that serum irisin levels were lower in overweight subjects. Moreover, serum irisin levels were inversely correlated with adverse metabolic parameters including WC, WHR, creatinine, HOMA-IR and fasting insulin, suggesting that irisin may play a role in obesity related insulin resistance.
Effect of Winter Canola Cultivar on Seed Yield, Oil, and Protein Content
Authors: Tetteh Edmund T. , de Koff Jason P. , Pokharel Bharat , Link Richard , Robbins Chris 
Published: August 2019

Canola (Brassica napus L.) is an oilseed crop that can produce healthy cooking oil and animal feed byproducts. Although it is a relatively new crop, approved for human consumption less than 40 yr ago, advances in breeding have allowed for its production as a winter crop in the southeastern United States. There is little published research, however, related to its performance and quality in this region. Therefore, a study was conducted during the 2014–2015 (Year 1) and 2015–2016 (Year 2) seasons in Tennessee. Twenty‐three varieties were planted in a randomized complete block design with four replications across both years to determine seed yield, seed oil, and seed protein content. Differences in fertilizer application rates, planting, and harvest management and differences in weather conditions probably led to significant interactions between years. Cultivar yields ranged from 1269 to 2647 and 1494 to 4199 kg ha−1, seed oil content ranged from 44 to 48% and from 43 to 46%, and seed protein content ranged from 20 to 24% and from 19 to 23% for Years 1 and 2, respectively. In each year, open‐pollinated cultivars had significantly lower yield and oil content but significantly greater protein content than hybrid cultivars. There was also a strong negative correlation between seed oil and seed protein and the linear models were significant (r = 0.88, p < 0.0001 for Year 1; r = 0.85, p < 0.0001 for Year 2). Recommended winter canola cultivars include Exp1302 and Hekip.Core Ideas

Little published research is available related to the performance of winter canola in the southeastern United States.
Yield, oil, and protein content were identified across 23 potential winter canola cultivars over 2 yr.
Significant linear relationships were observed between seed oil and protein content but not when compared with yield.
Unpredictable Nature of Environment on Nitrogen Supply and Demand
Authors: Raun William R. , Dhillon Jagmandeep , Aula Lawrence , Eickhoff Elizabeth , Weymeyer Gwen , Figueirdeo Bruno , Lynch Tyler , Omara Peter , Nambi Eva , Oyebiyi Fikayo , Fornah Alimamy 
Published: August 2019

The second law of thermodynamics states that entropy or randomness in a given system will increase with time. This is shown in science, where more and more biological processes have been found to be independent. Contemporary work has delineated the independence of yield potential (YP0) and nitrogen (N) response in cereal crop production. Each year, residual N in the soil following crop harvest is different. Yield levels change radically from year to year, a product of an ever‐changing and unpredictable/random environment. The contribution of residual soil N for next years’ growing crop randomly influences N response or the response index (RI). Consistent with the second law of thermodynamics, where it is understood that entropy increases with time and is irreversible, biological systems are expected to become increasingly random with time. Consequently, a range of different biological parameters will influence YP0 and RI in an unrelated manner. The unpredictable nature that environment has on N demand, and the unpredictable nature that environment has on final grain yield, dictate the need for independent estimation of multiple random variables that will be used in mid‐season biological algorithms of the future.Core Ideas

Randomness in biological systems is increasing.
Many biological processes are independent.
Yield levels change from one year to the next.
Environments change over time and are random.
Optimum fertilizer nitrogen rates change dramatically from year to year.
A procedure for designing natural water retention measures in new development areas under hydraulic-hydrologic invariance constraints
Authors: Masseroni Daniele , Ercolani Giulia , Chiaradia Enrico Antonio , Gandolfi Claudio 
Published: August 2019

AbstractIn recent years, in Italy and elsewhere, regional regulations based on hydraulic-hydrologic invariance (HHI) principles have taken hold, especially for new development areas. Natural water retention measures (NWRMs) are among the most interesting options to provide the storage and infiltration capacities that are needed to achieve the HHI objectives. A procedure for the design of NWRMs in new development areas under HHI constraints is presented and is based on a simple combination of Soil Conservation Service Curve Number (SCS-CN) method for determining rainfall excess and lag-time method for simulating runoff propagation. Three types of NWRMs can be considered: rain barrels, drainage wells and drainage trenches; five types of synthetic hyetographs can be selected and three different approaches for the determination of critical storm duration applied. The results obtained by applying the procedure in a new development area located in northern Italy are illustrated and some general conclusions are drawn. It clearly emerges that practitioners should pay particular attention to the correct determination of design storm duration in order to avoid large underestimations of NWRMs size. Moreover, different combinations of the three NWRMs can provide the required reduction of peak of runoff after the transformation, but it appears that drainage trenches are more effective with respect to harvesting systems in reducing the peak runoff value.
Is Pouch Specific to Colon and Not Ileum?
Authors: Gupta Sonal , Tiwari Pradeep , Gupta Nidhi , Nunia Vandana , Saxena Amulya K , Simlot Anita , Kothari Shanker Lal , Suravajhala Prashanth , Medicherla Krishna Mohan , Mathur Praveen 
Published: August 2019

Background:Congenital Pouch Colon (CPC) is an anorectal anomaly with an incidence of 3.5:1 in males and females, respectively. We have earlier reported CPC to be quite prevalent in north Indian tertiary care centers.Objective:n this article, we deliberate on the possible causes associated with CPC bringing the manifestation of the disease. In addition, we throw insights on the effective role of this congenital anomaly in Colon and provide systems genomic evaluation by comparing our recent analysis to that of Colon and Ileum based on Next-Generation Sequencing (NGS) studies.Conclusions:In this commentary article, we argue that a host of epigenetic factors could be the reason why the disease is manifested in colon alone. We further hypothesize on the few unmet challenges linking epigenetics to understand the genetic variants.
Development and Evaluation of Bioresponsive Tablets of a Selective COX-2 Inhibitor for Colonic Delivery
Authors: Tambe Srushti , Desai Namita 
Published: August 2019

Background:
We report the effectiveness of a targeted delivery system containing Meloxicam
using polysaccharides for the treatment of colorectal cancer. We also propose a novel biorelevant
dissolution method to overcome drawbacks of existing dissolution methodologies of polysaccharidebased
systems. The proposed method includes a mixture of probiotics cultured under anaerobic conditions
in the presence of prebiotic in the in vitro dissolution study to surrogate colonic conditions. Polysaccharide-
based system can be simple, safe and effective drug delivery system to target drugs to colon.

Methods:
Press-coated tablets of Meloxicam were prepared by direct compression using various polysaccharides,
such as xanthan gum, guar gum and pectin as coating polysaccharides. Developed tablets
were evaluated for physical parameters, lag phase and in vitro drug release. Developed probioticsbased
dissolution method was validated and explored for versatility using other polysaccharides.

Results:
Press-coated tablets of Meloxicam were successfully developed exhibiting targeted delivery to
the colon using guar gum as coat and releasing more than 80% of drug in simulated colonic fluid. The
developed probiotics based dissolution method may prove to be useful as a bio-relevant and discriminatory
method.

Conclusion:
Developed Meloxicam tablets press-coated with guar gum can be taken orally for treatment
or as an adjuvant therapy in colon cancer. Polymers used in this formulation are abundant, nontoxic,
biodegradable and inexpensive which make this a a very promising approach for the treatment of
different colonic diseases. The proposed biorelevant, animal sparing, probiotics based dissolution medium
was found to be versatile to study drug release from other polysaccharide based formulations for
colonic delivery.
Osteopathic Considerations for Peripheral Neuropathy Due to Concomitant Diffuse Idiopathic Skeletal Hyperostosis Syndrome and Lumbar Epidural Lipomatosis: Case Report
Authors: Chin Justin , Kviatkovsky Bina , Lomiguen Christine 
Published: August 2019

Background
Diffuse idiopathic skeletal hyperostosis (DISH) syndrome and lumbar epidural lipomatosis are relatively asymptomatic neurological conditions, with findings often seen incidentally on radiological studies.

Objective
The aim of this paper is to present unique findings of concomitant, symptomatic DISH syndrome and lumbar epidural lipomatosis and to discuss the osteopathic diagnosis and treatment implications.

Methods
Concomitant, symptomatic variants are rare and present challenges to treatment and management, as seen with a 60-year-old African American woman who presented with worsening disequilibrium and new-onset bilateral fingertip numbness. Past medical history was significant for alcohol abuse disorder, hypertension, hyperlipidemia, and multiple episodes of self-resolving vertigo and lower extremity neuropathy.

Results
The patient was referred to the neurology department for stroke workup, which was negative. Osteopathic structural exam revealed thoracolumbar and sacral dysfunctions. Magnetic resonance imaging revealed findings consistent with thoracic DISH syndrome and lumbar epidural lipomatosis in the areas of somatic dysfunctions.

Conclusions
Due to minimal information on osteopathic manipulative treatment in rare neurological diseases, only gentle techniques of myofascial release, balanced ligamentous tension, and muscle energy were performed with resultant minimal improvement, thus highlighting the necessity for better guidelines and further research.
Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts from Brain Dead Donors: Protocol for a Prospective Pilot Study
Authors: Meister Franziska Alexandra , Czigany Zoltan , Bednarsch Jan , Böcker Jörg , Amygdalos Iakovos , Morales Santana Daniel Antonio , Rietzler Katharina , Moeller Marcus , Tolba René , Boor Peter , Rohlfs Wilko , Neumann Ulf Peter , Lurje Georg 
Published: August 2019

Background
Kidney transplantation is the only curative treatment option for end-stage renal disease. The unavailability of adequate organs for transplantation has resulted in a substantial organ shortage. As such, kidney donor allografts that would have previously been deemed unsuitable for transplantation have become an essential organ pool of extended criteria donor allografts that are now routinely being transplanted on a global scale. However, these extended criteria donor allografts are associated with significant graft-related complications. As a result, hypothermic oxygenated machine perfusion (HOPE) has emerged as a powerful, novel technique in organ preservation, and it has recently been tested in preclinical trials in kidney transplantation. In addition, HOPE has already provided promising results in a few clinical series of liver transplantations where the liver was donated after cardiac death.

Objective
The present trial is an investigator-initiated prospective pilot study on the effects of HOPE on extended criteria donor allografts donated after brain death and used in kidney transplantation.

Methods
A total of 15 kidney allografts with defined inclusion/exclusion criteria will be submitted to two hours of HOPE via the renal artery before implantation, and are going to be compared to a case-matched group of 30 patients (1:2 matching) who had kidneys transplanted after conventional cold storage. Primary (posttransplant dialysis within 7 days) and secondary (postoperative complications, early graft function, duration of hospital and intensive care unit stay, and six-month graft survival) endpoints will be analyzed within a six-month follow-up period. The extent of ischemia-reperfusion injury will be assessed using kidney tissue, perfusate, and serum samples taken during the perioperative phase of kidney transplantation

Results
The results of this trial are expected in the first quarter of 2020 and will be presented at national and international scientific meetings and published in international peer-reviewed medical journals. The trial was funded in the third quarter of 2017 and patient enrollment is currently ongoing.

Conclusions
This prospective study is designed to explore the effects of HOPE on extended criteria donor kidney allografts donated after brain death. The present report represents the preresults phase.

Trial Registration
Clinicaltrials.gov NCT03378817; https://clinicaltrials.gov/ct2/show/NCT03378817
ANALISIS WACANA KRITIS PEMBERITAAN TENTANG ORMAS ISLAM PADA SITUS BERITA ONLINE
Authors: M.Si Gigit Mujianto, 
Published: August 2019

Dalam analisis wacana kritis Model Theo van Leeuwen, teks dipandang sebagai medium saluran kelompok yang dominan memanipulasi ideologi kepada kelompok yang tidak dominan melalui kampanye disinformasi yang sarat stigma. Stigma yang menjadi stempel/cap ormas Islam hadir dalam kesadaran khalayak melalui proses eksklusi dan proses inklusi. Melalui proses eksklusi, pengeluaran subjek dengan membuat dalih, dihadirkan dengan strategi: (1) pasivasi, meniadakan hadirnya aktor dalam teks; (2) nominalisasi, mengubah makna tindakan menjadi peristiwa; dan (3) penggantian anak kalimat, membuat subjek tersembunyi. Adapun melalui proses inklusi, peristiwa atau aktor disertai stigma, dihadirkan dengan strategi: (1) diferensiasi, menampilkan perbedaan yang kontras untuk menyudutkan; (2) objektivasi-abstraksi, menampilkan dalih objektif dan negatif; (3) kategorisasi, menghadirkan persepsi negatif; (4) determinasi, menampilkan anonimitas, tokoh, peristiwa, dan tokoh dengan konotasi negatif; (5) asimilasi, menghadirkan citra dan julukan negatif. Dengan berbagai strategi tersebut stempel/cap ormas Islam ditampilkan secara asosiatif untuk memberikan penguatan stigma ormas Islam guna memperoleh legitimasi nonformal, baik legitimasi politik maupun legitimasi peran.