bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Cancer Genomics in the United States: Views of Payers and Other Stakeholders on Challenges and the Role of Payers in Solutions
Authors: Trosman Julia R. , Weldon Christine B. , Kurian Allison W. , Mrig Emily , Phillips Kathryn A. 
Published: February 2025

PURPOSE
Genomic testing is crucial in cancer risk identification, diagnosis, and treatment. However, health care implementation is challenging, even for tests covered by insurance. US payers are important health care participants and may contribute to addressing implementation challenges. We explored whether and how payers consider their role in genomic test implementation, and the perspectives of nonpayer stakeholders on payers' participation.

METHODS
We conducted a group interview with private payers (N = 12) to elucidate views on their role in genomic test implementation, implementation challenges, and potential solutions. Subsequently, we conducted individual interviews (N = 10) with nonpayer stakeholders—five cancer advocacy groups and five medical societies working in cancer, examining their reactions to payer input and capturing additional ideas. Qualitative research methods were used to frame the study and analyze results.

RESULTS
Payers considered cancer genomics implementation important and expressed willingness and ability to be involved. They articulated specific challenges relevant to them, including underutilization of covered tests in clinical practice, inequitable test use, and inconsistencies across guidelines, and suggested specific solutions to collaborate on with other stakeholders. Stakeholders viewed payers' participation in implementation as appropriate and feasible, expressed willingness to work with payers where relevant, and concurred with the key challenges noted by payers. Stakeholders' agreement with payers' solutions varied, but they offered additional ideas for addressing challenges.

CONCLUSION
Both payers and other stakeholders considered payers' role in addressing genomics implementation challenges appropriate and feasible, and offered specific avenues for payer participation. Our findings inform efforts by payers and other stakeholders to address broad health care implementation. They may also help precision oncology professionals, cancer centers, and health systems to frame their own implementation efforts and influence a broader policy and implementation agenda.
Consequences of Medicare Advantage for Beneficiaries and Politics: Revisiting The Delegated Welfare State
Authors: Campbell Andrea Louise , Morgan Kimberly J. 
Published: February 2025

Abstract
The Delegated Welfare State (Morgan and Campbell 2011) explored the causes and possible consequences of the 2003 Medicare reform boosting private managed care plans in the delivery of Medicare benefits. In this paper, we review scholarship on beneficiary experience (access, costs, outcomes) and political feedbacks arising from the delegated governance reform to evaluate whether predictions about consumer behavior and policy entrenchment have manifested. We find that beneficiary experiences and satisfaction do not differ significantly between Medicare Advantage and traditional Medicare, and MA plans’ managed care techniques have cut per beneficiary spending. However, MA remains costlier to the federal government, per beneficiary, because of the outsized payments received by plan providers. Officials have failed to rectify these overpayments because of policy feedback effects – the empowerment of lobbying groups with a stake in the program and beneficiary support for it. Growing dependence on private plans to deliver health insurance for a large and politically influential constituency, senior citizens, has rendered government officials and elected politicians reluctant to imperil this market and the happiness of beneficiaries.
The Evolution of Medicare: Challenges, Responses, and Prospects
Authors: Glied Sherry , Frank Richard , Lui Brendan 
Published: February 2025

Abstract
The Medicare program has provided a near-universal source of health care coverage for America's elderly since 1965. Over its 60-year history, the program has evolved to cover a greater share of the population and pay for an increasing share of the nation's health care bills. As Medicare has grown, so too have its challenges. The traditional Medicare program has failed to keep pace with a rapidly changing health care sector and demographic shifts. Constrained by its own benefit design, Medicare has allowed privately-contracted health plans (Medigap, Medicare Advantage) to provide much needed yet inadequate remedies to the program's shortcomings. After briefly recounting Medicare's origins, we discuss how the program's founding statutes have hindered its ability to respond to new and growing challenges along the dimensions of cost-sharing, cost containment, and benefit design. We then propose a three-pronged approach to reforming Medicare's benefit structure. We argue that a simplified enrollment process, a single benefit that brings together the program's constituent parts (Part A, Part B, and Part D), and a new organizational structure for care delivery based on the program's experience with Accountable Care Organizations (ACOs), will together create a robust foundation that can sustain the Medicare program into the future.
Distributionally Robust Optimal Allocation with Costly Verification
Authors: Bayrak Halil İbrahim , Koçyiğit Çağıl , Kuhn Daniel , Pınar Mustafa Çelebi 
Published: February 2025

Allocation with Costly Verification under Ambiguity In “Distributionally Robust Optimal Allocation with Costly Verification,” Bayrak, Koçyiğit, Kuhn, and Pınar examine the mechanism design problem faced by a principal allocating a single good to one of several agents with costly verification and without monetary transfers, adopting a distributionally robust optimization perspective. Each agent desires the good and generates value for the principal, who does not initially know these values but can verify them at a cost. This problem arises in various scenarios, such as a venture capitalist selecting a start-up for funding or a procurement manager choosing a supplier. Many such allocation problems occur infrequently, leaving the principal with limited knowledge about the distribution of the agents’ values. The authors model these allocation problems as distributionally robust mechanism design problems, explicitly addressing distributional ambiguity. They introduce the first robustly (and Pareto-robustly) optimal mechanisms in the literature. These mechanisms are not only robust but also simple and interpretable.
Improving Flipped Academic Advising: Designing Materials for the Technology-Based Higher Education Landscape
Authors: Paschke Jaron D. , Ditta Annie S. 
Published: February 2025

Abstract
This study investigated best practices in creating and providing advising materials to students in an asynchronous online environment (i.e., flipped advising). Specifically, we examined the effects of creating advising tutorials in different modalities (i.e., text vs. video), and providing learning support via a pre-tutorial before engaging with the flipped advising content (i.e., pre-tutorial vs. no pre-tutorial). We found a significant interaction of these factors such that participants who watched video tutorials benefitted from having a pre-tutorial, but those who read text tutorials were hindered by the pre-tutorial. These results suggest that pre-tutorials warrant additional investigation, especially in the context of technology-driven flipped academic advising.
Career Advising in a VUCA Environment
Authors: Shaffer Leigh S. , Zalewski Jacqueline M. 
Published: February 2025

Abstract
Recent developments in the knowledge-driven, postindustrial economy have radically affected college students’ prospects for entering and completing successful careers. In this volatile, uncertain, complex, and ambiguous (VUCA) environment, fewer organizations find profitability in hiring, training, and retaining workers. Over the last 20 years, traditional careers, with lifelong security and opportunities for financial success, have been systematically replaced by a contract with workers who maintain their own employability. In addition, college degrees no longer assure graduates of having marketable knowledge and skills, and so traditional career advising yields limited results in a VUCA environment. This is the first in a series of articles outlining a human capital approach to career advising that addresses the challenges of a VUCA environment.
Changes in the distribution of the tear film lipid layer after intensive pulsed light combined with meibomian gland expression in patients with meibomian gland dysfunction
Authors: Lee Yongwoo , Lee Sung Woo , Yun Ji Kyu , Han So Young , Choi Chul Young 
Published: February 2025

Purpose
This study aimed to investigate changes in dry eye disease (DED) parameters and tear film lipid layer distribution after intensive pulse light (IPL) combined with meibomian gland expression (MGX) in patients with meibomian gland dysfunction (MGD).

Methods
This retrospective study included 218 patients diagnosed with MGD who underwent IPL combined with MGX. Various DED parameters, including tear film lipid layer thickness (LLT), were measured using a Placido disc tear film analyzer and slit lamp. Inferior corneal images were quantified and divided into upper, lower, nasal, and temporal quadrants, with further subdivision into six parts from top to bottom using Python.

Results
The ocular surface disease index, meibomian gland expressibility, and quality scores significantly improved after three treatment sessions. Slit-lamp-measured DED parameters also improved, excluding the fluorescein-stained tear meniscus height. Redness in the nasal limbal and bulbar conjunctivae significantly decreased. The mean LLT tended to increase after treatment. LLT in the upper half of the images, but not in the lower half, increased significantly, with the difference in LLT between the two halves decreasing significantly from 34.46 ±  15.73 to 30.27 ±  14.63 nm (p =  0.031). When the vertical distribution was analyzed by further subdivision into six equal parts from top to bottom, the average difference in LLT decreased in the uppermost segment after treatment.

Conclusion
IPL combined with MGX reduced the vertical distribution of lipids in patients with MGD by reducing lower tear film lipid layer stasis. Thus, the Placido disc tear film analyzer is a useful tool for analyzing lipid layer distribution in MGD.
The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review
Authors: Ryan Niamh , O’Mahony Siobhain , Leahy-Warren Patricia , Philpott Lloyd , Mulcahy Helen 
Published: February 2025

Background
Perinatal maternal stress, which includes both psychological and physiological stress experienced by healthy women during pregnancy and the postpartum period, is becoming increasingly prevalent. Infant early exposure to adverse environments such as perinatal stress has been shown to increase the long-term risk to metabolic, immunologic and neurobehavioral disorders. Evidence suggests that the human microbiome facilitates the transmission of maternal factors to infants via the vaginal, gut, and human milk microbiomes. The colonization of aberrant microorganisms in the mother’s microbiome, influenced by the microbiome-brain-gut axis, may be transferred to infants during a critical early developmental period. This transfer may predispose infants to a more inflammatory-prone microbiome which is associated with dysregulated metabolic process leading to adverse health outcomes. Given the prevalence and potential impact of perinatal stress on maternal and infant health, with no systematic mapping or review of the data to date, the aim of this scoping review is to gather evidence on the relationship between perinatal maternal stress, and the human milk, maternal, and infant gut microbiomes.

Methods
This is an exploratory mapping scoping review, guided by the Joanna Briggs Institute’s methodology along with use of the Prisma Scr reporting guideline. A comprehensive search was conducted using the following databases, CINAHL Complete; MEDLINE; PsycINFO, Web of Science and Scopus with a protocol registered with Open Science Framework DOI 10.17605/OSF.IO/5SRMV.

Results
After screening 1145 papers there were 7 paper that met the inclusion criteria. Statistically significant associations were found in five of the studies which identify higher abundance of potentially pathogenic bacteria such as Erwinia, Serratia, T mayombie, Bacteroides with higher maternal stress, and lower levels of stress linked to potentially beneficial bacteria such Lactococcus, Lactobacillus, Akkermansia. However, one study presents conflicting results where it was reported that higher maternal stress was linked to the prevalence of more beneficial bacteria.

Conclusion
This review suggests that maternal stress does have an impact on the alteration of abundance and diversity of influential bacteria in the gut microbiome, however, it can affect colonisation in different ways. These bacterial changes have the capacity to influence long term health and disease. The review analyses data collection tools and methods, offers potential reasons for these findings as well as suggestions for future research.
Hubungan Early Warning Scoring System dengan Mortalitas Pasien COVID-19 di Rumah Sakit Universitas Indonesia
Authors: Listiana Saetia , Adnan Nurhayati 
Published: February 2025

Background: Tingkat mortalitas COVID-19 di Indonesia sebesar 2,7%, angka ini merupakan yang tertinggi di Asia Tenggara. Pasien COVID-19 yang mengalami perburukan di rumah sakit seperti masuk ICU dan kematian sebanyak 15-20%. Perubahan klinis pasien sebelum terjadinya perburukan dan kematian tidak disadari oleh 27,06% tenaga kesehatan. Menurut WHO, EWS dapat digunakan untuk mendeteksi perburukan pasien lebih awal, namun penelitian yang dilakukan untuk melihat hubungan EWS dengan kematian COVID-19 masih terbatas. Tujuan penelitian ini adalah untuk mengetahui besar risiko highrisk EWS dengan kejadian kematian serta probabilitas kesintasan pada pasien COVID-19 yang dirawat di RS UI.Methods: Penelitian ini menggunakan desain studi kohort retrospektif. Populasi pada penelitian ini adalah seluruh pasien COVID-19 yang dirawat inap di RS UI pada periode Maret – Desember 2020. Penelitian ini menggunakan total sampling. Jumlah sampel pada penelitian ini adalah 740 orang yang terdiri dari 137 orang pada kelompok terpapar dan 603 kelompok tidak terpapar. Analisis kesintasan dilakukan dengan menggunakan Kaplan Meier sedangkan analisis multivariat dilakukan dengan cox regresi.Result: Probabilitas kesintasan pasien COVID-19 yang di rawat di RS UI sampai dengan 72 hari pengamatan sebesar 47,4%. Besar risiko pasien COVID-19 yang memiliki highrisk EWS untuk terjadi kematian sebesar 5,32 (95% CI= 3,26-8,69).Conclusion : Tenaga kesehatan diharapkan dapat mendeteksi perburukan pasien sedini mungkin agar bisa dilakukan intervensi lebih awal untuk mencegah kematian pada pasien COVID-19.
Carbon dioxide adsorption modeling to determine breakthrough curves in a fixed bed: isotherm and temperature effects
Authors: Esquivel G. Chavez , Shafeeyan Mohammad S. , Rodríguez Nava Celestino O. , Cabello-Robles Juan J. , Hernández Botello Mayuric T. , García-Martínez Julio Cesar 
Published: February 2025

Abstract
Carbon dioxide (CO2) is a major greenhouse gas produced by anthropogenic activities, such as industrial processes and energy consumption. This study focuses on CO2 adsorption, a widely used industrial method, specifically dynamic CO2 capture from the atmosphere using ammonia-modified granular activated carbon (OXA-GAC). The research integrates experimental investigations with mathematical modeling to optimize the adsorption process. A numerical solution for mass balance equations, formulated from partial differential equations (PDEs), was implemented using the method of lines (MOL). To simulate the CO2 breakthrough profile in the adsorption column, three kinetic models were employed: pseudo-first-order, pseudo-second-order, and Avrami. Among these, the Avrami model demonstrated the best fit, exhibiting the highest correlation factor with experimental kinetic data at 30 °C, 45 °C, and 60 °C. Furthermore, two equilibrium adsorption isotherms, Toth and Langmuir, were evaluated. For low CO2 concentrations, the Yoon-Nelson model outperformed the Thomas model, particularly at 30 °C and 45 °C across all C/C0 ratios. At 60 °C, the adsorption performance in the column was accurately represented by these models for C/C0 ratios below 0.7. This study contributes to the advancement of CO2 capture technologies by optimizing dynamic CO2 adsorption using OXA-GAC. It provides valuable insights into process optimization under varying temperature and concentration conditions, supporting the development of more efficient and sustainable carbon capture systems.
“We did something, but we did it differently…” Crisis, Resilience, and Innovation in Contemporary Hungarian Cheesemaking Practices
Authors: Balogh Pál Géza 
Published: February 2025

AbstractIn the following paper, based on a case study of a specific business sector comprising makers of Hungarian artisanal cheese, I examine the impact of radical changes in the external economic environment on individual economic practices. These changes are often experienced in the form of sudden shocks and crises, over which individuals have little influence. I present the complex situations these individuals face, their efforts to respond, and the potential innovations that may emerge as a result. Based on fieldwork among cheesemakers in Pest, Veszprém, and Baranya counties, the case study presents the complex impacts of two recent crises — the COVID-19 pandemic and the inflation crisis — on the different localities. Focusing on the notion of resilience, I demonstrate the varying responses of the studied cheesemakers to these diverse impacts. The fundamental differences between the two crises allow us to examine important aspects of the functioning of economic practices, including the practical benefits of the strategy of pursuing security and diversification in a crisis situation. The two crises highlighted in different ways the vitally important questions of personal contact and trust in the context of businesses that produce “local foods.” Such aspects represent an important advantage in terms of marketing, and a disadvantage when it comes to pricing. At the same time, the intensifying polycrisis makes the resilience of small-scale farms a key issue for the future.
Satellite remote sensing – A modern tool for monitoring mites (Acari)
Authors: Manu Minodora , Onete Marilena 
Published: February 2025

AbstractIn the present day, it has become extremely important to protect and use natural resources in a “smart” way, focusing on sustainability. Modern techniques which can provide information on the spatial variation, extent, potential and limitations of natural resources can be very useful for human society. Remote sensing technology works by measuring and recording the reflection and the emission of electromagnetic radiation from the target area using sensors. Research projects using this technique for monitoring arthropod diversity are scarce. In this paper we review the pros and cons of using satellite remote sensing for the monitoring of mites. We also discuss those fields for which this technique may be most suitable, and which are the best remote sensing indices to use. In total, 60 scientific papers were analysed and 55 remote sensing indices were assessed. Five indices stood out in terms of their frequency of use, being calculated not only for agricultural fields, orchards or greenhouses, but also in research connected with human health. Application of remote sensing methods to practical management requires: a) determining the scale at which mite invasion can reliably be estimated; b) improving the standardisation of aerial imagery; c) quantifying the environmental factors influencing the imagery; and d) conducting ground-level studies. Remote sensing should enable the effective monitoring of management outcomes and support sustainable land use.
Effects of green exercise and walking in natural environments on physiological and cognitive health
Authors: Bayrakdar Akan , Güneş Elif 
Published: February 2025

Background and Study Aim. Exposure to natural environments is an important factor in physical and mental well-being. However, the specific effects of outdoor walking on cognitive and physiological health still require the search for effective solutions. This study aims to examine the effects of walking exercises in natural environments on the physiological and cognitive health of university students.
Materials and Methods. Thirty-two university students leading a sedentary lifestyle participated in the study. The experimental group (age = 21.25 ± 1.61) walked in nature twice a week for eight weeks, covering distances ranging from 6 to 10 km. The control group (age = 22.00 ± 1.54) maintained their sedentary lifestyle during this period. Reaction time, accuracy rate, memory capacity, cognitive performance, resting heart rate (RHR), and oxygen saturation level (SpO₂) were measured before and after the study. These measurements were recorded using OpenSesame software and analyzed using the visual memory paradigm. Data were processed using SPSS 26.0 (IBM Corp., Armonk, NY), with statistical significance set at p < 0.05.
Results. Although reaction time increased by 5.15% in the experimental group, no significant difference was found. Accuracy rate (8.42%), memory capacity (7.52%), cognitive performance (9.60%), oxygen saturation (1.03%), and RHR (4.26%) improved significantly. Pre-test and post-test comparisons revealed significant differences (p < 0.001) in these variables. In the control group, a statistically significant difference was observed only in RHR, while no significant changes were found in other variables. Intergroup comparisons showed no significant difference in reaction time; however, accuracy rate, memory capacity, cognitive performance, oxygen saturation, and RHR demonstrated significant differences (p < 0.001).
Conclusions. Regular walking in natural environments positively affects cognitive and physiological health. It also improves RHR and oxygen saturation while enhancing cognitive performance.
Multiplexed Distributed Acoustic Sensing Offshore Central Oregon
Authors: Shi Qibin , Williams Ethan F. , Lipovsky Bradley P. , Denolle Marine A. , Wilcock William S. D. , Kelley Deborah S. , Schoedl Katelyn 
Published: February 2025

Abstract
Distributed acoustic sensing (DAS) on submarine fiber-optic cables is providing new observational insights into solid Earth processes and ocean dynamics. However, the availability of offshore dark fibers for long-term deployment remains limited. Simultaneous telecommunication and DAS operating at different wavelengths in the same fiber, termed optical multiplexing, offers one solution. In May 2024, we collected a four-day DAS dataset utilizing an L-band DAS interrogator and multiplexing on the submarine cables of the Ocean Observatory Initiative’s Regional Cabled Array offshore central Oregon. Our findings show that multiplexed DAS has no impact on communications and is unaffected by network traffic. Moreover, the quality of DAS data collected via multiplexing matches that of data obtained from dark fiber. With a machine-learning event detection workflow, we detect 31 T waves and the S wave of one regional earthquake, demonstrating the feasibility of continuous earthquake monitoring using the multiplexed offshore DAS. We also examine ocean waves and ocean-generated seismic noise. We note high-frequency seismic noise modulated by low-frequency ocean swell and hypothesize about its origins. The complete dataset is freely available.