bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and isokinetic strength differences: bilateral and ipsilateral variation by different sport activity
Authors: Maly Tomas , Mala Lucia , Bujnovsky David , Hank Mikulas , Zahalka Frantisek 
Published: February 2019

Abstract

Background
The purpose of this study was to investigate the morphological and isokinetic strength asymmetry and magnitude in young athletes.

Methods
One hundred and thirty nine male subjects (soccer, floorball, non-athletes) were measured for proportion of muscle mass between upper extremities (BADΔ) and lower extremities (BLDΔ). Moreover, the peak muscle torque of knee extensors (PTE) and flexors (PTF), ipsilateral (H:Q) and bilateral strength ratio (Q:Q, H:H) were measured.

Results
We found significant differences in observed parameters with respect to different sport activities (F = 13.02, p = 0.00,

η
p
2

$\eta^2_p$

= 0.80). Higher values of BADΔ were observed in the non-active (0.19 ± 0.11 kg) group compared with soccer players (0.10 ± 0.11 kg). We found a lower value of BLDΔ in floorball players (0.32 ± 0.11 kg) compared with soccer players (0.58 ± 0.27 kg) and non-active boys (0.63 ± 0.28 kg). Results revealed significantly higher PTE in soccer players compared with non-active boys and floorball players and higher Q:Q ratio in soccer players (10.99 ± 7.75%) compared with non-active boys (7.47 ± 5.92%).

Conclusions
This study revealed that there are morphological and strength asymmetries in the observed groups, which may have potential maladaptive effects (e.g. uncompensated overload of extremity) in athletes affected by specific load.
Radiation stability of phosphine oxide functionalized pillar[5]arenes
Authors: Geng Junshan , Wang Ying , Cai Yimin , Yang Bin , Yuan Lihua , Feng Wen 
Published: February 2019

Abstract
The radiation stability of three phosphine oxide functionalized pillar[5]arenes (POP5A) was studied by an electron accelerator with dose up to 5 MGy in air at room temperature. The structures of both irradiated and unirradiated pillar[5]arenes samples were comparatively characterized by Micro-FTIR, NMR, UV-vis, ESI-HRMS and HPLC techniques. The results revealed different degrees of radiation damage at different doses for POP5A, and the degradation products are mainly composed of organic species containing hydroxyl groups and carbonyl groups. The possible radiolytic degradation pathway was proposed. In addition, extraction of uranyl ion with irradiated POP5A samples was examined. The distribution ratio of uranyl ion was found to increase at low radiation dose and decrease until 3000 kGy. This is the first time that the irradiation stability of pillar[5]arenes derivative extractants has been studied in detail and it provides reliable data support for further application of pillar[5]arenes extractants in practical applications.
The Impact of VAAs on (non-Voting) Aspects of Political Participation: Insights from Panel Data Collected During the 2017 German Federal Elections Campaign
Authors: Manavopoulos Vasilis , Triga Vasiliki , Marschall Stefan , Wurthmann Lucas Constantin 
Published: February 2019

Abstract
Thus far, research on the effects of Voting Advice Applications has focused on some aspects of voting behavior, whether, for example, these online tools impact citizens’ likelihood to vote or their voting choices. Relatively under-researched remain questions concerning the relationship between using VAAs and other forms of engagement with politics, such as involvement in electoral campaigns and information seeking about politics and parties. This paper seeks to examine effects in these behaviors associated with VAA-use employing panel data generated during and after the period of the German Bundestag Federal Election in September, 2017. The data from roughly 1120 participants, sampled to be representative of the German internet users, were collected in four waves, 1 month before the election at the earliest and several weeks following at the latest. We find that VAA-use is positively associated with consuming information about politics through other media (e.g. TV) and other election-related information-seeking activities, such as reading party programmes. On the other hand, we find no statistically significant relationship between VAA-use and interpersonal talk about politics or more active engagement with electoral campaigns such as attending party rallies.
Reflections on habituality across other grammatical categories
Authors: Boneh Nora , Jędrzejowski Łukasz 
Published: February 2019

AbstractThe main aim of this introduction article is to give a general overview of how habituality has been investigated in the literature as a grammatical category. In doing so, we first elaborate on the question of how habituality can be characterized and what difficulties one encounters in determining its properties, which include non-contingent modal event recurrence. A brief discussion of these issues is given in Section 2. Section 3 outlines selected (conceptual and formal) connections between habituality and other grammatical categories. What our observations essentially indicate is that habituality, on the one hand, closely interacts with several TAM categories, most prominently imperfective aspect and its derivatives (progressive, continuative), and also interacts in special ways with modal categories, such as the evidential or the future, on the other hand, we also observe – as has been done previously – that habituality is often not encoded overtly and can be expressed by several forms within one and the same language, and if overtly marked by a dedicated form, diachronically, it is not always stable. Finally, Section 4 summarizes the most relevant findings of the articles collected in the present special issue and highlights their importance for the general discussion about habituality.
Burst Firing and Spatial Coding in Subicular Principal Cells
Authors: Simonnet Jean , Brecht Michael 
Published: February 2019

The subiculum is the major output structure of the hippocampal formation and is involved in learning and memory as well as in spatial navigation. Little is known about how neuronal diversity contributes to function in the subiculum. Previously,in vitrostudies have identified distinct bursting patterns in the subiculum. Here, we asked how burst firing is related to spatial codingin vivo. Using juxtacellular recordings in freely moving male rats, we studied the bursting behavior of 102 subicular principal neurons and distinguished two populations: sparsely bursting (∼80%) and dominantly bursting neurons (∼20%). These bursting behaviors were not linked to anatomy: both cell types were found all along the proximodistal and radial axes of the subiculum and all identified cells were pyramidal neurons. However, the distinct burst firing patterns were related to functional differences: the activity of sparsely bursting cells showed a stronger spatial modulation than the activity of dominantly bursting neurons. In addition, all cells classified as boundary cells were sparsely bursting cells. In most sparsely bursting cells, bursts defined sharper firing fields and carried more spatial information than isolated spikes. We conclude that burst firing is functionally relevant to subicular spatially tuned neurons, possibly by serving as a mechanism to transmit spatial information to downstream structures.SIGNIFICANCE STATEMENTThe subiculum is the major output structure of the hippocampal formation and is involved in spatial navigation.In vitro, subicular cells can be distinguished by their ability to initiate bursts as brief sequences of spikes fired at high frequencies. Little is known about the relationship between cellular diversity and spatial coding in the subiculum. We performed high-resolution juxtacellular recordings in freely moving rats and found that bursting behavior predicts functional differences between subicular neurons. Specifically, sparsely bursting cells have lower firing rates and carry more spatial information than dominantly bursting cells. Additionally, bursts fired by sparsely bursting cells encoded spatial information better than isolated spikes, indicating that bursts act as a unit of information dedicated to spatial coding.
Evaluation of the efficacy of Phyllanthus niruri standardized extract combined with magnesium and vitamin B6 for the treatment of patients with uncomplicated nephrolithiasis
Authors: Cealan Alexandru , Coman Radu-Tudor , Simon Vasile , Andras Iulia , Telecan Teodora , Coman Ioan , Crisan Nicolae 
Published: February 2019

Introduction. The aim of our study was to assess the efficacy of Phyllanthus niruri standardized extract, combined with magnesium and B6 vitamin, used to treat uncomplicated nephrolithiasis.
Patients and methods. We included in the present study 48 patients with uncomplicated nephrolithiasis, with the maximum calculi diameter of up to 15 mm, confirmed by non-contrast-enhanced computer tomography. Each patient followed a three-month therapeutic regimen with the above mentioned combination, with imaging assessment of the calculi after treatment.
Results. Per patient: The mean age of the patients was 48 years. The median number of calculi was 1 and the mean dimension was 5.5 mm. The stone-free status after treatment was not correlated with gender (p=0.7), side location (p=0.8) or with the number of calculi (p=0.3), but we found a correlation with the location in the upper or middle calyx (54.5% vs 13.8%, p=0.008) and with the maximum diameter (p=0.001). Per stone: 60 calculi were analyzed, 8.3% being located in the upper calyx, 36.7% in the middle and 55% in the lower one. After treatment, 40% were absent, 21.7% showed lower dimensions and 38.3% remained unchanged, with the mean reduction of 1.7 mm. We identified a cut-off value of ≤ 3 mm (AUC 0.9, CI:0.8-0.9, p<0.0001) for the prediction of stone-free status after treatment.
Conclusions. The current treatment had the highest efficacy in achieving stone-free status for patients with calculi ≤ 3 mm, located in the middle or upper calyx. A higher duration of the treatment might show improved results.
Retrospect and Prospect for Lung Cancer in China: Clinical Advances of Immune Checkpoint Inhibitors
Authors: Lu Shun , Yu Yongfeng , Yang Yi 
Published: February 2019

AbstractLung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths in China. The recent emergence of immunotherapy treatment options, such as the use of programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) checkpoint inhibitors, has also led to a paradigm shift in the treatment of non-small cell lung cancer, and has provided promising directions for the treatment of small cell lung cancer. This review provides a summary of the developmental process of immunotherapy, especially immune checkpoint inhibitors in lung cancer, ongoing international and domestic clinical trials in this field, and the challenges and considerations related to the use of immunotherapy in Chinese patients with lung cancer, with the aim of providing detailed information for future immunotherapy-related clinical trials in China. Research regarding immune checkpoint inhibitors in China is several years behind similar research in several developed countries. However, although PD-1/PD-L1 inhibitor-related clinical trials remain in their early stages in China, increased efforts by Chinese clinicians, researchers, and government staff have been directed toward trying to introduce novel drugs into the clinical setting. Because of the specific characteristics of Chinese patients with lung cancer (such as high epidermal growth factor receptor mutation rates, later disease stages, and different toxicity profiles), large-scale clinical trials targeting the Chinese population or Chinese participation in multinational trials should be promoted.
O Principado de Nero nos 'Anais' de Tácito
Authors: Coelho Ana Lucia Santos 
Published: February 2019

Resenha de: BELCHIOR, Y. K. Nero: bom ou mau imperador? Retórica, política e sociedade em Tácito (54 a 69 d.C.). Curitiba: Prismas, 2016. 288 p.
INVESTMENT PROGRAM OF POWER GRID COM PANIES: CHECK ALL CAN NOT BE SELECTED
Authors: Karle V. A. , Zolotova LYU. , Kechin S. A. 
Published: February 2019

Starting in 2017, the carrying out of technological and price audit of investment programs (projects of investment programs) and reports on their implementation has been secured as the necessary measures for the electric grid companies of Russia in the framework of approval procedures and approval of investment programs and oversee their implementation.Realization of technological and price audit requires to review large set of information in short period of time, which is limited by investment program validation procedures. Forming representative sample (which describes general population accurately) as an object of analysis could increase audit efficiency. The approach shown in the article is based on mathematical methods of analysis.On the example of the project of the investment program of PJSC "MOESK" the authors made an attempt to apply the described technique. This technique made it possible to perform the main task - the formation of a sample of investment projects, which allows without loss of quality and complexity of the investment program materials to preserve the validity and objectivity of the formed conclusion based on the results of technological and price audit.
INVESTMENTS IN DEVELOPMENT OF SUPPLY CHAINS
Authors: Balchik E. A. , Kalinina O. V. , Barykin S. E. 
Published: February 2019

The problems of investment in the development of supply chains are considered. The trends that are characteristic of investment processes in the industry are investigated, and problems of investing in the supply chain are highlighted, namely, the lack of a wellcoordinated partnership between the state and private business, underestimation of projects due to incomplete information about the characteristics of investment projects and underdeveloped investment assessment methodology. The authors confirmed the thesis that the development of investment in innovative solutions for supply chains is ensured by more active participation of stakeholders in the investment process.
MATHEMATICAL FORMALIZATION OF INSTITUTIONS
Authors: Obydenov A. Yu. 
Published: February 2019

The article proposes the way of mathematical formalization of institutions in the framework of game-theory approach. The rules are represented by transpositions of payoffs in payment matrix. Such the transitions call the change the structure of game equilibriums. This approach allows separation of coordination and distribution aspects of institutions, division institutions into classes and distinguishing aggregateс of institutions, which produce identical transformation. Through evolutionary game theory formalism it is shown that such parametric management influences the structure of steady states, what allows investigation of institutions’ influence on self-organization, in particular, through transformation of topology of phase portrait of the system. In accordance with the fact that dynamic with multiple steady states is typical for coordination problem as a whole, an approach suggested of the rules formalization appears to have rather broad application.
INFLUENCE OF INFORMATION SIGNALS ON THE FUTURE EARNINGS
Authors: Lutsenko S. I. 
Published: February 2019

It is considered of information signals on the future earnings of the Russian companies. Information signals can influence behaviour of investors at an estimation of the future earnings. Indicators of internal growth and shock can influence on earnings in the future. The shock indicator allows to consider a situation when the company will pass from debt financing to internal sources of financing to lower the wastage rate of assets connected with influence of shocks. Internal financing is performed at the expense of the cheapest source - earnings. It allows to reduce level of debt risk by means of capital structure adjustment (repayment of a part of amount of debt). Indicators of shock and internal growth for investors are the information indicator of prospects of development of the company.
Disruptions of spermatogenic function after testicle torsion in childhood and adolescence
Authors: Shormanov Igor S. , Shchedrov Dmitriy N. , Morozov Evgenij V. 
Published: February 2019

Aim of research. To assess the state of spermatogenesis in men after an experience of testicle torsion in childhood and adolescence.
Materials and methods. A semen analysis was performed involving 76 men, ages 18 to 29 years, who had testicle torsion in childhood and adolescence. Inclusion criteria in this study were an age of 18 years and an active sexual life. Analysis of the ejaculate was performed in accordance with the World Health Organization Guidelines for the study of human ejaculate. Macroscopic and microscopic evaluation of ejaculate, as well as assessment of motility, viability, number, and morphology of sperm was performed. The control group included 49 men who lacked potential risk factors for male infertility.
Results and discussion. Changes in the ejaculate depended on the patient's age, as well as the duration and degree of testicular ischemia. When the gonad was preserved after critical ischemia occurred, the spermogram indices were significantly worse than when performing primary orchiectomy, which indicates functional failure of the gonad following its atrophy and suggests that it is inadvisable to maintain the gonad with the expectation of improved long-term results.
Conclusions: 1. Changes in the spermogram after ischemia were observed in terms of sperm morphology and mobility. 2. The most pronounced changes in the spermogram were noted in patients who had experienced third-degree inversion of the testicle with preservation of gonads; the least pronounced changes were noted in patients who had experience inversion with spontaneous generation and incomplete inversion, which involved minimal ischemic damage. 3. The worst ischemia in puberty occurred in the context of mature sex glands. 4. There was a direct dependence of spermogram changes on the duration of acute ischemia. 5. The most unfavorable combination occurred in puberty, with disease lasting for more than 1 day, comprising complete inversion with “critical” ischemia. 6. After critical ischemia with preservation of the gonad, the semen is less favorable than after completion of orchiectomy, due to the failure of atrophied gonads; this finding casts doubt on the practice of gonad preservation.
MODELING OF QUALITY ASSURANCE INFORMATION SYSTEM FOR ISO-CERTIFIED HIGHER EDUCATION INSTITUTIONS
Authors: Legowo Mercurius Broto 
Published: February 2019

<pre><em>The purpose of this research is to develop a model of the quality assurance information system based on an integration of BAN-PT accreditation and ISO 9001: 2008 for ISO-certified higher education institutions. Problems that arise when the higher education has been certified ISO 9001: 2008 and will carry out accreditation of study program based on BAN-PT. Another problem is that higher education institutions do not have an integrated model of the quality assurance information system based on the integration of BAN-PT Accreditation and ISO 9001: 2008. </em><em>This study is the next stage of previous research showing a framework of accreditation results of BANT-PT and ISO 9001: 2008. </em><em>This National Strategy Research for Institutions is a type of applied research that uses a qualitative approach. The result of this research is a model of Quality Assurance Information System (QAIS) based on an integration of BAN-PT accreditation and ISO 0001: 2008 for ISO-certified higher education institutions. This QAIS modeling will later facilitate software application development at the next stage of research in the future. This Quality Assurance Information System will be able to support the change management of study program to improve the accreditation standard of study program significantly.</em><em></em></pre><pre><em><br /></em><em></em></pre>
Sildenafil does not affect the proliferation of human lymphocytes in the in vitro transplant model
Authors: Kaleta Beata 
Published: February 2019

Sildenafil is a selective inhibitor of type 5 phosphodiesterase (PDE5) used in the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Numerous studies revealed beneficial effects of sildenafil use in chronic kidney disease, and also in renal, liver, heart and bone marrow transplant recipients. Some reports suggest that sildenafil modulates function of the immune system, and additionally proliferation of endothelial, bone marrow and cancer cells. Despite the fact that PDE5 inhibitors showed efficacy and safety, it is very important to know whether these drugs have immunomodulatory properties, because are used in patients after organ transplantation. The influence of sildenafil on antigen-induced proliferation of lymphocytes remains currently unknown, thus the aim of the study was to investigate the effects of the drug on human peripheral blood mononuclear cells (PBMCs) proliferation in a mixed lymphocyte reaction (MLR).PBMCs were isolated from venous blood from 30 donors. The proliferation was examined on the DNA synthesis level by measurements of 3H-thymidine incorporation. Cell viability was determined using trypan blue exclusion method.The study demonstated that sildenafil at concentrations of 0.06 µM, 0.6 µM and 6µM did not affect auto- and alloantigen-induced proliferation of PBMCs and showed no cytotoxic effect. However, further analysis is required to fully understand the role of PDE5 inhibitors in the regulation of human immune system.
THE INFORMATION TECHNOLOGY LITERACY LEVEL OF NEWLY ENROLLED FEMALE COLLEGE STUDENTS IN JAPAN
Authors: Nishikawa Tomoko , Izuta Guido 
Published: February 2019

Purpose: The objective of the study was to assess the self-assessment of information literacy among newly enrolled Japanese female college student in what concerns to the ability to operate office applications; namely, word processors, spreadsheets and presentation software. In addition, researchers also investigated the time period when they started using them. Methodology: A survey was performed on 272 junior college female students of humanities courses and 41 college students of nutrition science course in April 2018, right after their entrance ceremonies. Statistical free software R was used to process the data, which consisted of chi-square test of independence for a contingency table, and correspondence analysis. The parameters assessed were (1) self-evaluation of the ability to use office applications, and (2) the period of time the students started using time. Main Findings: ‘Upper intermediate’ level students in word processors were correlated with the period around ‘Class in elementary school’ or ‘Class in junior high school’. By contrast, ‘Upper intermediate’ level students in spreadsheeting were associated with the first contact in a ‘Class in junior high school’ or ‘Class in high school’. Presentation software has been used frequently since elementary school up to high school and its club activities. Finally, the results suggest that ‘Advanced’ level students were taught how to use all these applications from family members. Implications: These findings may help teachers to improve their academic curriculum in order to fill the gap between those who are skilled and those who are not. They also can give useful hints to explore new teaching methods on information literacy subjects in higher education. Novelty: The results suggest that that the period of time that students had their first contact with the applications affects the awareness of their importance and the motivation to learn them.