bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease
Authors: Bertagnolli Mariane , Xie Li Feng , Paquette Katryn , He Ying , Cloutier Anik , Fernandes Rafael Oliveira , Béland Chanel , Sutherland Megan R. , Delfrate Jacques , Curnier Daniel , Bigras Jean‐Luc , Rivard Alain , Thébaud Bernard , Luu Thuy Mai , Nuyt Anne Monique 
Published: July 2018

Background

Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm‐born infants, especially endothelial colony‐forming cells (
ECFC
), show enhanced susceptibility to prematurity‐related pro‐oxidant stress. Whether
ECFC
dysfunction is present in adulthood following preterm birth is unknown.

Methods and Results

This cross‐sectional observational study includes 55 preterm‐born (≤29 gestational weeks) young adults (18–29 years old, 38% male) and 55 sex‐ and age‐matched full‐term controls.
ECFC
were isolated from peripheral blood; cell proliferative and vascular cord formation capacities were assessed in vitro. Daytime systolic blood pressure was higher, whereas glucose tolerance and body mass index were lower in preterm‐born subjects.
ECFC
colonies grew in culture for 62% of full‐term‐ and 58% of preterm‐born participants. Preterm‐born participants have formed
ECFC
colonies later in culture and have reduced proliferation compared with controls. Only in preterm‐born individuals, we observed that the later the
ECFC
colony grows in culture, the worse was overall
ECFC
function. In addition, in preterms, elevated systolic blood pressure significantly correlated with reduced
ECFC
proliferation (

r
S

=−0.463;
P
=0.030) and numbers of branches formed on matrigel (

r
S

=−0.443;
P
=0.039). In preterm‐born subjects, bronchopulmonary dysplasia was associated with impaired
ECFC
function, whereas exposure to antenatal steroids related to better
ECFC
function.

Conclusions

This study is the first to examine
ECFC
in preterm‐born adults and to demonstrate
ECFC
dysfunction compared with full‐term controls. In the preterm‐born group,
ECFC
dysfunction was associated with bronchopulmonary dysplasia, the major prematurity‐related neonatal morbidity, and with increased systolic blood pressure into adulthood.
Cortical Microinfarcts on 3T Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy
Authors: van den Brink Hilde , Zwiers Angela , Switzer Aaron R. , Charlton Anna , McCreary Cheryl R. , Goodyear Bradley G. , Frayne Richard , Biessels Geert Jan , Smith Eric E. 
Published: July 2018

Background and Purpose—
Cerebral microinfarcts are small ischemic lesions that are found in cerebral amyloid angiopathy (CAA) patients at autopsy. The current study aimed to detect cortical microinfarcts (CMI) on in vivo 3 Tesla (3T) magnetic resonance imaging (MRI) in CAA patients, to study the progression of CMI over a 1-year period, and to correlate CMI with markers of CAA-related vascular brain injury and cognitive functioning.

Methods—
Thirty-five CAA patients (mean age, 74.2±7.6 years), 13 Alzheimer disease (AD) patients (67.0±5.8 years), and 26 healthy controls (67.2±9.5 years) participated in the study. All participants underwent a standardized clinical and neuropsychological assessment as well as 3T MRI. CMI were rated according to standardized criteria.

Results—

CMI were present in significantly more CAA patients (57.1%; median number: 1, range 1–9) than in Alzheimer disease (7.7%) or in healthy controls (11.5%;
P
<0.001). Incident CMI were observed after a 1-year follow-up. CMI did not correlate with any other MRI marker of CAA nor with cognitive function.

Conclusions—
In vivo CMI are a frequent finding on 3T MRI in CAA patients, and incident CMI are observable after 1-year follow-up. CMI can be regarded as a new MRI marker of CAA, potentially distinct from other well-established markers. Future larger cohort studies with longitudinal follow-up are needed to elucidate the relationship between CMI and possible causes and clinical outcomes in CAA.
Ultraearly Intravenous Thrombolysis for Acute Ischemic Stroke in Mobile Stroke Unit and Hospital Settings
Authors: Tsivgoulis Georgios , Geisler Frederik , Katsanos Aristeidis H. , Kõrv Janika , Kunz Alexander , Mikulik Robert , Rozanski Michal , Wendt Matthias , Audebert Heinrich J. 
Published: July 2018

Background and Purpose—
Mobile stroke units (MSUs) are known to increase the proportion of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) in the first golden hour (GH) after onset compared with hospital settings (HS). However, because of the low number of AIS patients treated with intravenous thrombolysis within this ultraearly time window in conventional care, characteristics, and outcome of this subgroup of AIS patients have not been compared between MSU and HS.

Methods—
MSU-GH patients were selected from the Berlin-based MSU (STEMO [Stroke Emergency Mobile]), whereas HS-GH patients were selected from the SITS-EAST (Safe Implementation of Treatments in Stroke-East) registry. The outcome events of interest included the rates of favorable functional outcome (modified Rankin Scale scores of 0 or 1), distribution of the modified Rankin Scale scores, and mortality after 3 months between MSU-GH and HS-GH groups.

Results—

We identified 117 MSU-GH (38.4% of 305 MSU-treated patients) and 136 HS-GH (0.9% of 15 591 HS-treated patients) eligible patients without prestroke disability. No significant differences were documented in the rates of favorable functional outcome (51.3% versus 46.2%,
P
=0.487) and mortality (7.7% versus 9.9%,
P
=0.576) at 3 months, or in the distribution of 3-month modified Rankin Scale scores between the 2 groups (
P
=0.196). In multivariable logistic regression analyses, adjusting for potential confounders, MSU treatment was not associated with a significantly different likelihood of favorable functional outcome (odds ratio, 1.84 for MSU patients; 95% CI, 0.86–3.96) or mortality (odds ratio, 0.95; 95% CI, 0.28–3.20) at 3 months.

Conclusions—
There is no evidence that safety and efficacy of ultraearly intravenous thrombolysis for AIS differs when used in MSUs or in HS.
Explicit Prediction of Hail in a Long-Lasting Multicellular Convective System in Eastern China Using Multimoment Microphysics Schemes
Authors: Luo Liping , Xue Ming , Zhu Kefeng , Zhou Bowen 
Published: July 2018

Abstract
During the afternoon of 28 April 2015, a multicellular convective system swept southward through much of Jiangsu Province, China, over about 7 h, producing egg-sized hailstones on the ground. The hailstorm event is simulated using the Advanced Regional Prediction System (ARPS) at 1-km grid spacing. Different configurations of the Milbrandt–Yau microphysics scheme are used, predicting one, two, and three moments of the hydrometeor particle size distributions (PSDs). Simulated reflectivity and maximum estimated size of hail (MESH) derived from the simulations are verified against reflectivity observed by operational S-band Doppler radars and radar-derived MESH, respectively. Comparisons suggest that the general evolution of the hailstorm is better predicted by the three-moment scheme, and neighborhood-based MESH evaluation further confirms the advantage of the three-moment scheme in hail size prediction. Surface accumulated hail mass, number, and hail distribution characteristics within simulated storms are examined across sensitivity experiments. Results suggest that multimoment schemes produce more realistic hail distribution characteristics, with the three-moment scheme performing the best. Size sorting is found to play a significant role in determining hail distribution within the storms. Detailed microphysical budget analyses are conducted for each experiment, and results indicate that the differences in hail growth processes among the experiments can be mainly ascribed to the different treatments of the shape parameter within different microphysics schemes. Both the differences in size sorting and hail growth processes contribute to the simulated hail distribution differences within storms and at the surface.
Identification of Hydrologic Models, Optimized Parameters, and Rainfall Inputs Consistent with In Situ Streamflow and Rainfall and Remotely Sensed Soil Moisture
Authors: Wright Ashley J. , Walker Jeffrey P. , Pauwels Valentijn R. N. 
Published: July 2018

Abstract
An increased understanding of the uncertainties present in rainfall time series can lead to improved confidence in both short- and long-term streamflow forecasts. This study presents an analysis that considers errors arising from model input data, model structure, model parameters, and model states with the objective of finding a self-consistent set that includes hydrological models, model parameters, streamflow, remotely sensed (RS) soil moisture (SM), and rainfall. This methodology can be used by hydrologists to aid model and satellite selection. Taking advantage of model input data reduction and model inversion techniques, this study uses a previously developed methodology to estimate areal rainfall time series for the study catchment of Warwick, Australia, for multiple rainfall–runoff models. RS SM observations from the Soil Moisture Ocean Salinity (SMOS) and Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E) satellites were assimilated into three different rainfall–runoff models using an ensemble Kalman filter (EnKF). Innovations resulting from the observed and predicted SM were analyzed for Gaussianity. The findings demonstrate that consistency between hydrological models, model parameters, streamflow, RS SM, and rainfall can be found. Joint estimation of rainfall time series and model parameters consistently improved streamflow simulations. For all models rainfall estimates are less than the observed rainfall, and rainfall estimates obtained using the Sacramento Soil Moisture Accounting (SAC-SMA) model are the most consistent with gauge-based observations. The SAC-SMA model simulates streamflow that is most consistent with observations. EnKF innovations obtained when SMOS RS SM observations were assimilated into the SAC-SMA model demonstrate consistency between SM products.
Qualitative exploration of critical health literacy among Afghan and Congolese refugees resettled in the USA
Authors: Im Hyojin , Swan Laura ET 
Published: July 2018

Objectives: Previous research that revealed a high prevalence of low health literacy among immigrants and refugees tended to over emphasise functional health literacy as a risk factor for low health status and poor disease management. Despite a significant knowledge gap, little has been investigated regarding critical health literacy (CHL) in refugee populations whose culture deeply interweaves individual and contextual capacity to promote health. Design: This study adopted a qualitative approach to explore CHL that is built through community health workshops (CHWs) with Afghan and Congolese refugee communities in US resettlement. Setting: As part of a community-based participatory research project, the study was conducted with Afghan and Congolese refugees resettled in the USA. Method: A series of open-ended questions for focus group interviews were embedded in each workshop session explore health literacy skills and capacity over time. This study adopted a hybrid thematic design whereby the conceptual framework of CHL was applied to emergent themes from the data. Results: Thematic analysis revealed four major CHL thematic domains, as experienced and demonstrated by Afghan and Congolese refugee participants: (1) critical appraisal, (2) self-efficacy and confidence, (3) empowerment, and (4) collective problem solving. Conclusion: Study findings underline the importance of health education validating existing cultural knowledge and practices in a group setting so as to facilitate the building and enhancement of social support systems and community action for health promotion.
Present-day geothermal regime of the Uliastai Depression, Erlian Basin, North China
Authors: Xu Wei , Huang Shaopeng , Zhang Jiong , Yu Ruyang , Zuo Yinhui , Zhou Yongshui , Chang Junhe 
Published: July 2018

In this study, we calculated the present-day terrestrial heat flow of the Uliastai Depression in Erlian Basin by using systematical steady-state temperature data obtained from four deep boreholes and 89 thermal conductivity measurements from 22 boreholes. Then, we calculated the lithospheric thermal structure, thermal lithospheric thickness, and lithospheric thermo-rheological structure by combining crustal structure, thermal conductivity, heat production, and rheological parameter data. Research from the Depression shows that the present-day terrestrial heat flow ( qs) is 86.3 ± 2.3 mW/m2, higher than the average of 60.4 ± 12.3 mW/m2 of the continental area of China. Mantle heat flow ( qm) in the Depression ranges from 33.7 to 39.3 mW/m2, qm/ qs ranges from 40 to 44%, show that the crust plays the dominant position in the terrestrial heat flow. The thermal thickness of the lithosphere is about 74–88 km and characterized by a “strong crust–weak mantle” rheological characteristic. The total lithospheric strength is 1.5 × 1012 N/m under wet mantle conditions. Present-day geothermal regime indicates that the Uliastai Depression has a high thermal background, the activity of the deep-seated lithosphere is relatively intense. This result differs significantly from the earlier understanding that the area belongs to a cold basin. However, a hot basin should be better consistent with the evidences from lithochemistry and geophysical observations. The results also show the melts/fluids in the study area may be related to the subduction of the Paleo-Asian Ocean. The study of the geothermal regime in the Uliastai Depression provides new geothermal evidence for the volcanic activity in the eastern part of the Central Asian Orogenic Belt and has significant implications for the geodynamic characteristics.
Acidic stress induces protective autophagy in SGC7901 cells
Authors: Sheng Jie , Sun Li-Bin , Zhao Shu-Fen , Qi Wei-Wei , Lv Jing , Zhang Zhong-Guang , Ding Ai-Ping , Qiu Wen-Sheng 
Published: July 2018

Objective To investigate the effect of acidity on gastric cancer SGC7901 cells in terms of autophagy and provide a new strategy for therapeutically targeting gastric cancer autophagy in an acidic environment. Methods Transmission electron microscopy (TEM) and confocal laser scanning microscopy were used to examine the effect of an acidic environment on autophagosome formation. Light chain 3 (LC3) and p62 levels in SGC7901 cells exposed to acidic conditions were measured using Western blot analysis. To explore changes in autophagy flux, the cells were treated with an inhibitor of autophagy bafilomycin A1. The CCK-8 assay was performed to determine if inhibiting acid-induced autophagy affected cell proliferation. Results Increased autophagosome formation was observed by TEM. Punctate LC3 structures were observed in cells cultured under acidic conditions, whereas untreated cells exhibited diffuse and weak staining for punctate LC3 structures. Cytoplasmic LC3-I translocated to the autophagic membrane (LC3-II) levels increased under acidic conditions, whereas p62 levels decreased. The bafilomycin A1-induced inhibition of autophagy caused by the acidic environment inhibited cell proliferation. Conclusion The acidic environment upregulates autophagy in SGC7901 cells. In long-term culture, a stable and high level of autophagy is maintained in an acidic environment, which has a protective effect on cells.
Neoadjuvant chemotherapy followed by interval debulking surgery for unresectable stage IVB Serous endometrial cancer
Authors: Bogani Giorgio , Ditto Antonino , Leone Roberti Maggiore Umberto , Scaffa Cono , Mosca Lavinia , Chiappa Valentina , Martinelli Fabio , Lorusso Domenica , Raspagliesi Francesco 
Published: July 2018

Objective: To test the safety and effectiveness of neoadjuvant chemotherapy followed by interval debulking surgery in unresectable stage IVB serous endometrial cancer. Methods: Data of consecutive stage IVB serous endometrial cancer are reviewed. Patients undergoing neoadjuvant chemotherapy plus interval debulking surgery were propensity matched with patients undergoing primary surgery followed by adjuvant treatment. Results: Thirty-four patients were diagnosed with a stage IVB endometrial cancer. Fifteen (44.1%) patients had neoadjuvant chemotherapy followed by interval debulking surgery; while 19 (55.8%) patients had primary cytoreduction. Among this latter group, 15 (78.9%) patients were selected, using a propensity-matched algorithm. Results of propensity-matching baseline characteristics of patients included were similar between groups. Patients having neoadjuvant chemotherapy plus interval debulking surgery had shorter length of hospital stay (4 [1.40] vs 6 [2.5] days; p=0.011) compared with patients in the control group. Moreover, patients in the neoadjuvant chemotherapy group experienced a trend toward shorter operative time (127 [62] vs 177.6 [84.5] minutes; p=0.072) and lower transfusion rate than patients in the control group (6.6% vs 33.3%; p=0.067). Cytoreduction rate was similar between groups (p=0.962). No difference in postoperative morbidity was recorded. Median disease-free survival was 12.0 vs 15.3 months in the experimental vs control group (p=0.663; log-rank test). Median overall survival was 16.7 vs 18.0 months in the experimental vs control group (p=0.349; log-rank test). Conclusions: Neoadjuvant chemotherapy might be a valuable treatment modality for patients with unresectable stage IVB serous endometrial cancer. Innovative treatments are warranted in this cluster of patients.
Economic benefits of treating medication-overuse headache – results from the multicenter COMOESTAS project
Authors: Jellestad Pernille Linde , Carlsen Louise Ninett , Westergaard Maria Lurenda , Munksgaard Signe Bruun , Bendtsen Lars , Lainez Miguel , Fadic Ricardo , Katsarava Zaza , Goicochea Maria Teresa , Spadafora Santiago , Jensen Rigmor Højland , Nappi Giuseppe , Tassorelli Cristina ,   the COMOESTAS Consortium
Published: July 2018

Background Medication-overuse headache is a costly disease for individuals and society. Objective To estimate the impact of medication-overuse headache treatment on direct and indirect headache-related health care costs. Methods This prospective longitudinal study was part of the COMOESTAS project (COntinuous MOnitoring of Medication Overuse Headache in Europe and Latin America: development and STAndardization of an Alert and decision support System). Patients with medication-overuse headache were included from four European and two Latin American headache centers. Costs of acute medication, costs of health care services, and measurements of productivity were calculated at baseline and at 6-month follow-up Treatment consisted of overused drug withdrawal with optional preventive medication. Results A total of 475 patients (71%) completed treatment and were followed up for 6 months. Direct health care costs were on average reduced significantly by 52% ( p < 0.001) for the total study population. Significant reductions were seen in both number of consumed tablets (−71%, p < 0.001) and number of visits to physicians (−43%, p < 0.001). Fifty percent of patients reduced their number of consumed tablets ≥ 80%. Headache-related productivity loss, calculated either as absence from work or ≥ 50% reduction of productivity during the workday, were reduced by 21% and 34%, respectively ( p < 0.001). Conclusion Standardized treatment of medication-overuse headache in six countries significantly reduced direct health care costs and increased productivity. This emphasizes the importance of increasing awareness of the value of treating medication-overuse headache. Trial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056)
Graft-Recipient Anteroposterior Mismatch Does Not Affect the Midterm Clinical Outcomes of Osteochondral Allograft Transplantation of the Femoral Condyle
Authors: Wang Dean , Coxe Francesca R. , Balazs George C. , Chang Brenda , Jones Kristofer J. , Rodeo Scott A. , Williams Riley J. 
Published: July 2018

Background: For the treatment of femoral condyle cartilage defects with osteochondral allograft transplantation (OCA), many surgeons have relaxed their graft-recipient size-matching criteria given the limited allograft supply. However, since the anteroposterior (AP) length is typically correlated with the radius of curvature for a given condyle, a large mismatch in graft-recipient AP length can indicate a corresponding mismatch in the radius of curvature, leading to articular incongruity after implantation. Purpose: To evaluate the association between femoral condyle graft–recipient AP mismatch and clinical outcomes of OCA. Study Design: Case-control study; Level of evidence, 3. Methods: A retrospective review was conducted of patients treated with OCA for femoral condyle chondral defects from 2000 to 2015. Graft characteristics, including AP and mediolateral dimensions, were gathered from vendor-specific allograft offering documents. Patient condyle dimensions were measured on preoperative magnetic resonance imaging. Reoperations and patient responses to validated outcome measures were reviewed. Failure was defined by any partial removal/revision of the allograft or conversion to knee arthroplasty. A multivariable logistic regression model was fitted to examine the association of AP mismatch with OCA failure while adjusting for patient age and number of previous ipsilateral knee surgical procedures. Results: A total of 69 knees from 69 patients (mean age, 35.7 years; 71% male) met the inclusion criteria. Mean duration of follow-up was 4 years (range, 2-16 years). The mean absolute graft-recipient AP mismatch was 6.7 mm (range, 0-20 mm; P < .01). At final follow-up, 19 knees had failed. There was no significant difference in the mean absolute AP mismatch between failures (8.1 mm) and nonfailures (6.2 mm; P = .17). Multivariate logistic regression revealed that AP mismatch was not associated with graft failure ( P = .14). At final follow-up, significant improvements were noted in the 36-Item Short Form Health Survey, International Knee Documentation Committee subjective form, and Knee Outcome Survey–Activities of Daily Living ( P < .01 for all). Magnitude of AP mismatch was not associated with postoperative outcome scores or achievement of minimal clinically significant differences in outcome scores. Conclusion: Magnitude of graft-recipient AP mismatch was not associated with midterm OCA failure rates or patient-reported outcome scores, suggesting that AP length mismatch within the limits measured here is not a contraindication for graft acceptance.