bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine use of feeding jejunostomy in oesophageal cancer resections: results of a survey in England
Authors: Tham J C , Dovell G , Berrisford R G , Humphreys M L , Wheatley T J , Sanders G , Ariyarathenam A V 
Published: October 2019

SUMMARY
Nutrition and post-operative feeding in oesophageal cancer resections for enhanced recovery remain a controversial subject. Feeding jejunostomy tubes (FJT) have been used post-operatively to address the subject but evidence to support its routine use is contentious. There is currently no data on FJT use in England for oesophageal cancer resections. Knowledge regarding current FJT usage, and rationale for its use may provide a snapshot of the trend and current standing on FJT use by resectional units in England. A standardised survey was sent electronically to all oesophageal resectional units in the United Kingdom (UK) between October 2016 and January 2018. In summary, the questionnaire probes into current FJT use, rationale for its usage, consideration of cessation of its use, and rationale of cessation of its use for units not using FJT. The resectional units were identified using the National Oesophago-Gastric Cancer Audit (NOGCA) progress report 2016 and 1 selected resectional unit from Northern Ireland, Scotland, and Wales, respectively. Performance data of those units were collected from the 2017 NOGCA report. Out of 40 units that were eligible, 32 (80.0%) centres responded. The responses show a heterogeneity of FJT use across the resectional centres. Most centres (56.3%) still place FJT routinely with 2 of 18 (11.1%) were considering stopping its routine use. FJT was considered a mandatory adjunct to chemotherapy in 3 (9.4%) centres. FJT was not routinely used in 9 (28.1%) of centres with 5 of 9 (55.6%) reported previous complications and 4 of 9 (44.4%) cited using other forms of nutrition supplementation as factors for discontinuing FJT use. There were 5 (15.6%) centres with divided practice among its consultants. Of those 2 of 5 (40.0%) were considering stopping FJT use, and hence, a total of 4 of 23 (17.4%) of units are now considering stopping routine FJT use. In conclusion, the wider practice of FJT use in the UK remains heterogenous. More research regarding the optimal post-operative feeding regimen needs to be undertaken.
Do all roads lead to Rome? Treatment of malposition pacemaker lead in the left ventricle
Authors: Schmiady Martin Oliver , Hofmann Michael , Maisano Francesco , Morjan Mohammed 
Published: October 2019

Abstract
Malpositioning of a pacemaker lead in the left ventricle is a rare device-related complication, which can lead to serious complications. Herein, we describe the case of a malpositioned lead, which entered the left ventricle via a direct transcutaneous puncture of the left common carotid artery.
Interannual dynamics of zooplankton in the Kola Section of the Barents Sea during the recent warming period
Authors: Prokopchuk Irina P , Trofimov Alexander G 
Published: October 2019

Abstract
Our research focused on the analysis of interannual variability of zooplankton in the Kola Section (the Barents Sea) in the period of current warming in the Arctic basing on previously unpublished data. The zooplankton community was investigated based on the analysis of 240 plankton samples, collected in late May–early June 2009–2017. A total of 74 zooplankton taxa of nine phyla were identified in the plankton samples, but copepods were the most diverse and numerous taxonomic group. The biodiversity index varied considerably from year to year, but a stable tendency for the index to increase since the beginning of the period studied was observed. Copepods dominated in terms of abundance and biomass, comprising on average 73–96% of the total zooplankton abundance and 81–96% of the total zooplankton biomass. Calanus finmarchicus was the main zooplankton species utterly dominated by abundance and biomass (on average 92 and 97% respectively). Considerable differences in zooplankton abundance and biomass at different stations of the section were observed. Although the investigations were carried out during a warming period, interannual differences in zooplankton abundance and biomass were observed. Zooplankton biomasses were higher in the years with higher temperatures and stronger water inflow.
Uncertain sovereignty: Ceylon as a Dominion 1948–1972
Authors: Abeyratne Rehan 
Published: October 2019

Abstract
This article, a contribution to a symposium on dominion constitutionalism, looks at sovereignty in Ceylon’s Dominion period (1948–1972). While the Ceylon Constitution has been the subject of in-depth historical and sociopolitical study, it has received less attention from legal scholars. This article hopes to fill that gap. It analyzes Ceylon Supreme Court and Privy Council judgments from this era on both rights-based and structural questions of constitutional law. In each area, sovereignty-related concerns influenced the judicial approach and case outcomes. On fundamental rights, both the Supreme Court and the Privy Council adopted a cautious approach, declining to invalidate legislation that had discriminatory effects on minority communities. This reluctance to entrench fundamental rights resulted, at least in part, from judges’ undue deference to the Ceylon Parliament, which was wrongly looked upon like its all-powerful British progenitor. On constitutional structure, the Ceylon Supreme Court deferred to Parliament even when legislation encroached into the judicial realm. The Privy Council, though, was not so passive. It upheld a separate, inviolable judicial power that Parliament could not legislate away. But by asserting itself as a check on legislative power, the Council—as a foreign judicial body intervening in Ceylonese affairs—stoked concerns that Ceylon was less than fully sovereign, which ultimately ended Dominion status.
Usefulness of routine use of bilateral axillary artery perfusion in total arch replacement
Authors: Nishimura Yoshiharu , Honda Kentaro , Yuzaki Mitsuru , Kaneko Masahiro , Fujimoto Takahiro , Agematsu Kouta , Nagashima Mitsugi 
Published: October 2019

Abstract

OBJECTIVES
To avoid cerebral infarction for aortic arch aneurysm and malperfusion for acute aortic dissection, the site of cannulation during total arch replacement remains important. Recently, we have used bilateral axillary artery perfusion in total arch replacement and in acute aortic dissection. Herein, we report the surgical outcomes.

METHODS
Seventy-eight patients with aortic arch aneurysm and 45 patients with acute aortic dissection were enrolled in this study. During surgery, translocation of the total arch was performed on 67 patients using a ‘frozen elephant trunk technique’.

RESULTS
In patients with aortic arch aneurysm, there was no postoperative cerebral infarction. New postoperative cerebral infarction was observed in only one patient who underwent acute aortic dissection. Two patients who had aortic arch aneurysm and 2 patients who had acute aortic dissection died at the hospital. Complications related to bilateral axillary perfusion were not observed.

CONCLUSIONS
The routine use of bilateral axillary artery perfusion in total arch replacement for aortic arch aneurysm to avoid cerebral infarction has the potential to be a useful procedure. It can facilitate the frozen elephant trunk procedure in acute aortic dissection.
Gevrey Expansions of Hypergeometric Integrals II
Authors: Castro-Jiménez Francisco-Jesús , Fernández-Fernández María-Cruz , Granger Michel 
Published: October 2019

AbstractWe study integral representations of the Gevrey series solutions of irregular hypergeometric systems under certain assumptions. We prove that, for such systems, any Gevrey series solution, along a coordinate hyperplane of its singular support, is the asymptotic expansion of a holomorphic solution given by a carefully chosen integral representation.
Wind Power with Energy Storage Arbitrage in Day-ahead Market by a Stochastic MILP Approach
Authors: GOMES I L R , MELICIO R , MENDES V M F , POUSINHO H M I 
Published: October 2019

Abstract
This paper is about a support information management system for a wind power (WP) producer having an energy storage system (ESS) and participating in a day-ahead electricity market. Energy storage can play not only a leading role in mitigation of the effect of uncertainty faced by a WP producer, but also allow for conversion of wind energy into electric energy to be stored and then released at favourable hours. This storage provides capability for arbitrage, allowing an increase on profit of a WP producer, but must be supported by a convenient problem formulation. The formulation proposed for the support information management system is based on an approach of stochasticity written as a mixed integer linear programming problem. WP and market prices are considered as stochastic processes represented by a set of scenarios. The charging/discharging of the ESS are considered dependent on scenarios of market prices and on scenarios of WP. The effectiveness of the proposed formulation is tested by comparison of case studies using data from the Iberian Electricity Market. The comparison is in favour of the proposed consideration of stochasticity.
Laparoscopic repair of a right-sided paraduodenal hernia
Authors: Walkner Stephanie , Nebiker Christian A 
Published: October 2019

Abstract
With an incidence of less than 1%, paraduodenal hernias are very rare but account for ~0.2–5.8% of mechanical small bowel obstruction and carry a mortality rate of 20–50%. Right-sided paraduodenal hernias are three times less frequent than left-sided paraduodenal hernias. We report the case of a 37-year-old man who suffered from colicky abdominal pain accompanied by vomiting. The computed tomography scan showed a mechanical ileus, caused by a presumed paraduodenal hernia, and we chose an elective laparoscopic surgical approach. The patient recovered quickly and was discharged on the second postoperative day. Paraduodenal hernias are a diagnostic challenge as they are typically characterized by long-term non-specific abdominal symptoms and are only detected in the event of acute intestinal obstruction. Until now, laparoscopic therapy has only been described in eight case reports and we review this rare condition and the surgical options.
A rare case of multi-focal non-contiguous necrotizing soft tissue infections and literature review
Authors: Xu Yaying Eileen , Gounder Vinay 
Published: October 2019

Abstract
Necrotising soft tissue infection (NSTI) is a rare yet life-threatening surgical emergency, characterized by rapidly spreading infection below the epidermis to the soft tissue layers of the dermis, subcutaneous layers, fascia and sometimes muscle. Multi-focal NSTIs have been rarely described in the literature, with reported cases predominantly involving immunocompromised patients. We report a case of an immunocompromised 70-year-old woman who initially presented with concern of a perforated colonic malignancy requiring exploratory laparotomy and within 24 hours while on inotropes, developed rapidly progressing necrotizing fasciitis (NF) of the left thigh with renal failure secondary to sepsis. Despite aggressive debridement, a progress computed tomography later showed multi-focal non-contiguous necrotising myositis of the whole left lower limb and right gluteal regions. Early diagnosis of multi-focal NF especially in immunocompromised patients, repeat assessment, aggressive surgical debridement and prompt antibiotics usage are the key to treatment.
In silico study of the role of cell growth factors in photosynthesis using a virtual leaf tissue generator coupled to a microscale photosynthesis gas exchange model
Authors: Retta Moges A , Abera Metadel K , Berghuijs Herman Nc , Verboven Pieter , Struik Paul C , Nicolaï Bart M 
Published: October 2019

Abstract
Computational tools that allow in silico analysis of the role of cell growth and division on photosynthesis are scarce. We present a freely available tool that combines a virtual leaf tissue generator and a two-dimensional microscale model of gas transport during C3 photosynthesis. A total of 270 mesophyll geometries were generated with varying degrees of growth anisotropy, growth extent, and extent of schizogenous airspace formation in the palisade mesophyll. The anatomical properties of the virtual leaf tissue and microscopic cross-sections of actual leaf tissue of tomato (Solanum lycopersicum L.) were statistically compared. Model equations for transport of CO2 in the liquid phase of the leaf tissue were discretized over the geometries. The virtual leaf tissue generator produced a leaf anatomy of tomato that was statistically similar to real tomato leaf tissue. The response of photosynthesis to intercellular CO2 predicted by a model that used the virtual leaf tissue geometry compared well with measured values. The results indicate that the light-saturated rate of photosynthesis was influenced by interactive effects of extent and directionality of cell growth and degree of airspace formation through the exposed surface of mesophyll per leaf area. The tool could be used further in investigations of improving photosynthesis and gas exchange in relation to cell growth and leaf anatomy.
The small GTPase Rab5a and its guanine nucleotide exchange factors are involved in post-Golgi trafficking of storage proteins in developing soybean cotyledon
Authors: Wei Zhongyan , Pan Tian , Zhao Yuyang , Su Bohong , Ren Yulong , Qiu Lijuan 
Published: October 2019

Abstract
Storage protein is the most abundant nutritional component in soybean seed. Morphology-based evidence has verified that storage proteins are initially synthesized on the endoplasmic reticulum, and then follow the Golgi-mediated pathway to the protein storage vacuole. However, the molecular mechanisms of storage protein trafficking in soybean remain unknown. Here, we clone the soybean homologs of Rab5 and its guanine nucleotide exchange factor (GEF) VPS9. GEF activity combined with yeast two-hybrid assays demonstrated that GmVPS9a2 might specifically act as the GEF of the canonical Rab5, while GmVPS9b functions as a common activator for all Rab5s. Subcellular localization experiments showed that GmRab5a was dually localized to the trans-Golgi network and pre-vacuolar compartments in developing soybean cotyledon cells. Expression of a dominant negative variant of Rab5a, or RNAi of either Rab5a or GmVPS9s, significantly disrupted trafficking of mRFP–CT10, a cargo marker for storage protein sorting, to protein storage vacuoles in maturing soybean cotyledons. Together, our results systematically revealed the important role of GmRab5a and its GEFs in storage protein trafficking, and verified the transient expression system as an efficient approach for elucidating storage protein trafficking mechanisms in seed.
Redox homeostasis in the growth zone of the rice leaf plays a key role in cold tolerance
Authors: Gázquez Ayelén , Abdelgawad Hamada , Baggerman Geert , Van Raemdonck Geert , Asard Han , Maiale Santiago Javier , Rodríguez Andrés Alberto , Beemster Gerrit T S 
Published: October 2019

AbstractWe analysed the cellular and molecular changes in the leaf growth zone of tolerant and sensitive rice varieties in response to suboptimal temperatures. Cold reduced the final leaf length by 35% and 51% in tolerant and sensitive varieties, respectively. Tolerant lines exhibited a smaller reduction of the leaf elongation rate and greater compensation by an increased duration of leaf growth. Kinematic analysis showed that cold reduced cell production in the meristem and the expansion rate in the elongation zone, but the latter was compensated for by a doubling of the duration of cell expansion. We performed iTRAQ proteome analysis on proliferating and expanding parts of the leaf growth zone. We identified 559 and 542 proteins, of which 163 and 210 were differentially expressed between zones, and 96 and 68 between treatments, in the tolerant and sensitive lines, respectively. The categories protein biosynthesis and redox homeostasis were significantly overrepresented in the up-regulated proteins. We therefore measured redox metabolites and enzyme activities in the leaf growth zone, demonstrating that tolerance of rice lines to suboptimal temperatures correlates with the ability to up-regulate enzymatic antioxidants in the meristem and non-enzymatic antioxidants in the elongation zone.
Chromatin dynamics during interphase and cell division: similarities and differences between model and crop plants
Authors: Pecinka Ales , Chevalier Christian , Colas Isabelle , Kalantidis Kriton , Varotto Serena , Krugman Tamar , Michailidis Christos , Vallés María-Pilar , Muñoz Aitor , Pradillo Mónica 
Published: October 2019

AbstractGenetic information in the cell nucleus controls organismal development and responses to the environment, and finally ensures its own transmission to the next generations. To achieve so many different tasks, the genetic information is associated with structural and regulatory proteins, which orchestrate nuclear functions in time and space. Furthermore, plant life strategies require chromatin plasticity to allow a rapid adaptation to abiotic and biotic stresses. Here, we summarize current knowledge on the organization of plant chromatin and dynamics of chromosomes during interphase and mitotic and meiotic cell divisions for model and crop plants differing as to genome size, ploidy, and amount of genomic resources available. The existing data indicate that chromatin changes accompany most (if not all) cellular processes and that there are both shared and unique themes in the chromatin structure and global chromosome dynamics among species. Ongoing efforts to understand the molecular mechanisms involved in chromatin organization and remodeling have, together with the latest genome editing tools, potential to unlock crop genomes for innovative breeding strategies and improvements of various traits.
A perspective on crassulacean acid metabolism photosynthesis evolution of orchids on different continents: Dendrobium as a case study
Authors: Li Ming-He , Liu Ding-Kun , Zhang Guo-Qiang , Deng Hua , Tu Xiong-De , Wang Yan , Lan Si-Ren , Liu Zhong-Jian 
Published: October 2019

AbstractMembers of the Orchidaceae, one of the largest families of flowering plants, evolved the crassulacean acid metabolism (CAM) photosynthesis strategy. It is thought that CAM triggers adaptive radiation into new niche spaces, yet very little is known about its origin and diversification on different continents. Here, we assess the prevalence of CAM in Dendrobium, which is one of the largest genera of flowering plants and found in a wide range of environments, from the high altitudes of the Himalayas to relatively arid habitats in Australia. Based on phylogenetic time trees, we estimated that CAM, as determined by δ 13C values less negative than –20.0‰, evolved independently at least eight times in Dendrobium. The oldest lineage appeared in the Asian clade during the middle Miocene, indicating the origin of CAM was associated with a pronounced climatic cooling that followed a period of aridity. Divergence of the four CAM lineages in the Asian clade appeared to be earlier than divergence of those in the Australasian clade. However, CAM species in the Asian clade are much less diverse (25.6%) than those in the Australasian clade (57.9%). These findings shed new light on CAM evolutionary history and the aridity levels of the paleoclimate on different continents.
From diffuse extragalactic and galactic gamma-rays to limits on extra dimensions
Authors: Cassé Michel , Mansoulié Bruno , Silk Joseph 
Published: October 2019

ABSTRACT
We derive the maximum fraction of energy emitted in the form of massive (Kaluza–Klein) gravitons by core collapse supernovae, and the corresponding minimal extra-dimensional Planck mass M* in the ADD gravity framework at TeV scales. Our constraints arise (a) from the extragalactic gamma-ray background observed by Fermi-LAT after astrophysical sources have been removed and (b) via the residual galactic emission left after astrophysical and potentially dark matter emission have been removed. We focus on a number of extra dimensions 3 and 4, since M* is then in the TeV range, where astrophysical and collider constraints compete. Lower limits on M* are derived in the case (a) of 8.0 and 1.1 TeV for n = 3 and n = 4, respectively, and in the case (b) of 16 and 1.9 TeV. These limits are especially robust and insensitive to the various uncertainties involved.
Hyperkalemia and blood pressure regulation
Authors: Mutig Kerim , Bachmann Sebastian 
Published: October 2019

AbstractHypertension is common in the general population. Management of hypertensive patients at risk of hyperkalemia is challenging due to potential life-threatening complications such as cardiac arrest. Chronic hyperkalemia is often associated with impaired renal ability to excrete excessive potassium ions (K+). This may refer to chronic kidney disease or certain pharmacological interventions, including broadly used renin–angiotensin–aldosterone system and calcineurin inhibitors. Understanding the intrinsic mechanisms permitting kidney adaptations to hyperkalemia is critical for choosing therapeutic strategies. Valuable insights were obtained from the analysis of familial hyperkalemic hypertension (FHHt) syndrome, which became a classic model for coincidence of high blood pressure and hyperkalemia. FHHt can be caused by mutations in several genes, all of them resulting in excessive activity of with-no-lysine kinases (WNKs) in the distal nephron of the kidney. WNKs have been increasingly recognized as key signalling enzymes in the regulation of renal sodium ions (Na+) and K+ handling, enabling adaptive responses to systemic shifts of potassium homoeostasis consequent to variations in dietary potassium intake or disease. The WNK signalling pathway recruits a complex protein network mediating catalytic and non-catalytic effects of distinct WNK isoforms on relevant Na+- or K+-transporting proteins. In this review article, we summarize recent progress in understanding WNK signalling. An update of available models for renal adaptation to hyperkalemic conditions is presented. Consequences for blood pressure regulation are discussed. Pharmacological targeting of WNKs or their substrates offers promising options to manage hypertension while preventing hyperkalemia.