bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study of self-rated health among older adults: a comparison of China and the United States
Authors: Xu Dongjuan , Arling Greg , Wang Kefang 
Published: August 2019

ObjectivesWe used nationally representative samples of China and the US older population to investigate (1) whether factors influencing self-rated health among older Chinese were similar to those among older Americans; and (2) whether there was a significant cross-national difference in self-rated health between China and the USA after controlling those available influencing factors.DesignA cross-sectional study. Data came from the 2014 Health and Retirement Study and China Health and Retirement Longitudinal Study conducted from 2014 to 2015.ParticipantsOur final sample size totaled 8905 older adults in the USA and 4442 older adults in China.OutcomeThe response variable was self-rated health. Ordered logistic regression models were conducted to investigate factors influencing self-rated health among older adults.ResultsMore than three-fourths (78%) of older adults in China reported fair or poor health status, while almost 74% of older adults in the USA reported excellent, very good or good health status. In the overall ordered logistic regression model, when controlling statistically for sociodemographics, family structure, functional limitations, cognition, chronic conditions, mental health and health-related behaviours, the Chinese survey respondents were much more likely to rate their health as being poorer than the US respondents. The odds of having better versus poorer health was almost five times greater in American older adults than those in China (OR=4.88, 95% CI 4.06 to 5.86). Older adults in China living alone rated their health better than those living with spouse/partner; however, no significant difference was found between these two living arrangements in older Americans. In contrast, older adults in the USA living with others rated their health worse compared with those living with spouse/partner. In addition, older adults who had more activities of daily living limitations, poorer self-reported memory, worse mental health and chronic health conditions had lower self-rated health in both countries.ConclusionsWe found a striking difference in self-rated health between China and the USA even after controlling for measures of disease, functional status and other influencing factors. Relative to their American counterparts, Chinese elders were much more likely to report worse health.
Is the introduction of violence and injury observatories associated with a reduction in violence-related injury in adult populations? A systematic review and meta-analysis
Authors: Jabar Ardil , Fong Francisco , Chavira Monica , Cerqueira Maria Teresa , Barth Dylan , Matzopoulos Richard , Engel Mark E 
Published: August 2019

ObjectiveThe aim of this study was to summarise the results from existing studies reporting on the effectiveness of the introduction of violence and injury observatories (VIOs).DesignThis is a systematic review and meta-analysis study.Data sourcesWe searched multiple electronic databases including but not limited to PubMed, PsycINFO, SCOPUS, Cochrane Collaboration, Campbell Collaboration and Web of Knowledge.Eligibility criteriaWe included non-randomised controlled trials, quasi-experimental designs, prospective and retrospective cohort studies, controlled before-and-after studies and cross-sectional studies. We sought to include studies performed in any country and published in any language. The primary outcome was homicide, while the secondary outcome was assault.Data extraction and synthesisWe searched a number of databases, supplemented by searches in grey literature including technical reports. Searches comprised studies from January 1990 to October 2018.ResultsOf 3105 potentially relevant unique citations from all literature searches, 3 empirical studies and 4 technical reports met our inclusion criteria. Studies were conducted in the UK (n=3), Colombia (n=2), Brazil (n=1) and Uruguay (n=1). Subgroup analyses according to the two types of models implemented, the VIO and the injury surveillance system (ISS), provided evidence for an association between implementing the VIO model and a reduction in homicide count in high-violence settings (incidence rate ratio (IRR)=0.06; 95% CI 0.02 to 0.19; four studies), while the introduction of ISS showed significant results in reducing assault (IRR=0.80; 95% CI 0.71 to 0.91; three studies).ConclusionThis systematic review provides the best evidence available for the effectiveness of the introduction of VIOs and ISSs in reducing violence outcomes in adults in high-violence settings. The implementation of VIOs should be considered in high-violence communities where reduction in homicide rates is desired.PROSPERO registration numberCRD42014009818.
Is a clinician’s personal history of domestic violence associated with their clinical care of patients: a cross-sectional study
Authors: McLindon Elizabeth , Humphreys Cathy , Hegarty Kelsey 
Published: August 2019

ObjectiveTo investigate whether domestic violence (DV) impacts on health professionals’ clinical care of DV survivor patients.Design, settingDescriptive, cross-sectional study at an Australian tertiary maternity hospital.Participants471 participating female health professionals (45.0% response rate).Outcome measuresUsing logistic and linear regression, we examined whether health professionals’ exposure to lifetime DV was associated with their clinical care on specific measures of training, attitudes, identification and intervention.ResultsDV survivor health professionals report greater preparedness to intervene with survivor patients in a way that is consistent with ideal clinical care. This indicates that personal DV experience is not a barrier, and may be a facilitator, to clinical care of survivor patients.ConclusionsHealth professionals are at the front line of identifying and responding to patients who have experienced DV. These findings provide evidence that survivor health professionals may be a strength to the healthcare organisations in which they work since among the participants in this study, they appear to be doing more of the work seen as better clinical care of survivor patients. We discuss the need for greater workplace supports aimed at promoting safety and recovery from violence and strengthening clinical practice with patients.
CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease
Authors: Teuber-Hanselmann Sarah , Rekowski Jan , Vogelgsang Jonathan , von Arnim Christine , Reetz Kathrin , Stang Andreas , Jöckel Karl-Heinz , Wiltfang Jens , Esselmann Herrmann , Otto Markus , Tumani Hayrettin , Herring Arne , Keyvani Kathy 
Published: August 2019

ObjectiveThere is still an urgent need for supportive minimally invasive and cost-effective biomarkers for early diagnosis of Alzheimer’s disease (AD). Previous work in our lab has identified Kallikrein-8 (KLK8) as a potential candidate since it shows an excessive increase in human brain in preclinical disease stages. The aim of this study was to evaluate the diagnostic performance of cerebrospinal fluid (CSF) and blood KLK8 for AD and mild cognitive impairment (MCI) due to AD.MethodsIn this multi-centre trans-sectional study, clinical and laboratory data as well as CSF and/or blood serum samples of 237 participants, including 98 patients with mild AD, 21 with MCI due to AD and 118 controls were collected. CSF and/or serum KLK8 levels were analysed by ELISA. The diagnostic accuracy of KLK8 in CSF and blood was determined using receiver operating characteristic (ROC) analyses and compared with that of CSF core biomarkers Aβ42, P-tau and T-tau.ResultsThe diagnostic accuracy of CSF KLK8 was as good as that of core CSF biomarkers for AD (area under the curve (AUC)=0.89) and in case of MCI (AUC=0.97) even superior to CSF Aβ42. Blood KLK8 was a similarly strong discriminator for MCI (AUC=0.94) but slightly weaker for AD (AUC=0.83).ConclusionsThis is the first study to demonstrate the potential clinical utility of blood and CSF KLK8 as a biomarker for incipient AD. Future prospective validation studies are warranted.
Changes in risky sexual behaviours among West African MSM enrolled in a quarterly HIV testing and counselling prevention programme (CohMSM ANRS 12324 – Expertise France)
Authors: Coulaud Pierre-Julien , Sagaon-Teyssier Luis , Mimi Mohamed , Maradan Gwenaëlle , Mora Marion , Bourrelly Michel , Dembélé Keita Bintou , Keita Abdoul Aziz , Anoma Camille , Yoro Stéphane-Alain Babo , Dah Elias Ter Tiero , Coulibaly Christian , Mensah Ephrem , Agbomadji Selom , Palvadeau Pamela , Bernier Adeline , Rojas Castro Daniela , Couderc Clotilde , Laurent Christian , Spire Bruno 
Published: August 2019

ObjectivesWhether regular HIV testing and counselling reduce risky sexual behaviours in African men who have sex with men (MSM) is still a matter for debate. We aimed to identify behavioural trajectories based on HIV risk exposure (HRE) and factors affecting their evolution.MethodsData were collected from 621 HIV-negative West African MSM (Mali, Cote d'Ivoire, Burkina Faso and Togo) included in a community-based cohort providing quarterly HIV testing and counselling. Sociobehavioural data were collected every 6 months. HRE was defined as reporting inconsistent condom use during receptive anal sex with male partners of unknown HIV status in the previous 6 months. Using 18-month follow-up data, group-based trajectory modelling helped identify behavioural trajectories and determine the factors associated with their evolution. HIV seroconversions (n=67) were specified in each group trajectory.ResultsTwo distinct group trajectories were identified: medium-risk exposure MSM (ME-MSM) (61%, 6.4% of whom having seroconverted) and high-risk exposure MSM (HE-MSM) (39%, 17.5% of whom having seroconverted). A significant declining trend in the probability of reporting HRE over time ((95% CI)) was observed for HE-MSM (from 0.59 (0.48 to 0.70) at M0 to 0.31 (0.22 to 0.41) at M18), while it remained constant for ME-MSM (0.034 (0.0 to 0.079)). This can be explained by a progressive use of risk reduction strategies (less receptive anal sex, better knowledge of their partners’ status and increasing condom use). Being younger, living in Burkina Faso, self-considering both a man and a woman and reporting a higher level of depression were all associated with HE membership. Among HE-MSM, HRE was higher in those practising transactional or group sex and those experiencing psychological harassment.ConclusionsQuarterly HIV testing and counselling seem to reduce risky sexual behaviours in HIV-negative MSM at greatest risk of infection. Specific support for young MSM, focusing on identity and mental health, is needed to strengthen HIV prevention in West African MSM.
THE EFFECT OF TECHNOLOGICAL RISK, MARKET UNCERTAINTY AND THE LEVEL OF COMPLEXITY ON NEW TECHNOLOGY VENTURES’ SUCCESS
Authors: SADEH ARIK , DVIR DOV 
Published: August 2019

Innovations in products and services have become a necessity for the survival of modern organizations. The impact of Complexity, Technological risk and Market risk and uncertainty on the success of new technological ventures is investigated. The Complexity dimension reflects the way new ventures are managed during the development and marketing phases. The Novelty dimension reflects market uncertainty, mainly affects the way information about the customers' needs is collected and incorporated into the product design. The technology dimension, deals with the way the development process should be managed. Higher levels of technological risk require longer development periods, more design cycles and later design freeze. Projects are classified by their level of Novelty, Complexity and Technological risk. Structural equation modeling is used in this study to explore the relationships between the various components describing the innovation nature and assessing its success. The study's approach enables testing the relationships between the dependent variables (the Success Measures) and the innovation characteristics. It is shown that building technological infrastructure and new knowledge or technology has a greater impact on the venture's success than meeting operational and economic goals. The question this paper is trying to answer is what factors are more important and how organizations should structure their market and technological strategy. We found that there is no contradiction between high levels of risk or uncertainty and business success. The success of system ventures is significantly higher than the success of lower levels of complexity. Older and more experienced entrepreneurs are likely to be engaged in more complex and novel initiatives than younger, less experienced ones. This study highlights the importance of technological risk with respect to market uncertainty. It is shown that to overcome technological obstacles and to enrich the developing organization with better knowhow and technology will lead to higher innovation success. Although risk and uncertainty that are associated with technology and market may have a negative impact on innovations' success, they are also a source for new opportunities. The research investigates the impact of Technological risk and Market uncertainty on Innovations' success. This approach enables to identify the most important factors affecting technological innovations success.
Impacts of aquatic walking on arterial stiffness, exercise tolerance, and physical function in patients with peripheral artery disease: a randomized clinical trial
Authors: Park Song-Young , Kwak Yi-Sub , Pekas Elizabeth J. 
Published: August 2019

Peripheral artery disease (PAD) is an atherosclerotic disease that is associated with attenuated vascular function, cardiorespiratory capacity, physical function, and muscular strength. It is essential to combat these negative effects on health by incorporating lifestyle interventions to slow disease progression, such as exercise. We sought to examine the effects of aquatic walking exercise on cardiovascular function, cardiorespiratory capacity [maximal volume of oxygen consumption (V̇o2max)], exercise tolerance [6-min walking distance (6MWD)], physical function, muscular strength, and body composition in patients with PAD. Patients with PAD ( n = 72) were recruited and randomly assigned to a 12-wk aquatic walking training group (AQ, n = 35) or a control group (CON, n = 37). The AQ group performed walking and leg exercises in waist-to-chest-deep water. Leg arterial stiffness [femoral-to-ankle pulse wave velocity (legPWV)], heart rate (HR), blood pressure (BP), ankle-to-brachial index (ABI), V̇o2max, 6MWD, physical function, muscular strength, body composition, resting metabolic rate (RMR), and flexibility were measured before and after 12 wk. There were significant group × time interactions ( P < 0.05) after 12 wk for legPWV and HR, which significantly decreased ( P < 0.05) in AQ, and V̇o2max, 6MWD, physical function, and muscular strength, which significantly increased ( P < 0.05) in AQ, compared with no changes in CON. There were no significant differences ( P > 0.05) for BP, ABI, RMR, or flexibility after 12 wk. Interestingly, there was relatively high adherence (84%) to the aquatic walking exercise program in this population. These results suggest that aquatic walking exercise is an effective therapy to reduce arterial stiffness and resting HR and improve cardiorespiratory capacity, exercise tolerance, physical function, and muscular strength in patients with PAD.NEW & NOTEWORTHY The results of this study reveal for the first time that aquatic walking exercise can decrease arterial stiffness and improve exercise tolerance, cardiorespiratory capacity, and muscular strength in patients with peripheral artery disease (PAD). Aquatic walking exercise training demonstrates relatively high exercise adherence in this population. Aquatic walking exercise training may be a useful therapeutic intervention for improving physical function in patients with PAD.
FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor–Positive (HR+) Breast Cancer
Authors: Drago Joshua Z. , Formisano Luigi , Juric Dejan , Niemierko Andrzej , Servetto Alberto , Wander Seth A. , Spring Laura M. , Vidula Neelima , Younger Jerry , Peppercorn Jeffrey , Yuen Megan , Malvarosa Giuliana , Sgroi Dennis , Isakoff Steven J. , Moy Beverly , Ellisen Leif W. , Iafrate A. John , Arteaga Carlos L. , Bardia Aditya 
Published: August 2019

Abstract

Purpose:
While FGFR1 amplification has been described in breast cancer, the optimal treatment approach for FGFR1-amplified (FGFR1+) metastatic breast cancer (MBC) remains undefined.
Experimental Design: We evaluated clinical response to endocrine and targeted therapies in a cohort of patients with hormone receptor–positive (HR+)/HER2− MBC and validated the functional role of FGFR1-amplification in mediating response/resistance to hormone therapy in vitro.

Results:
In the clinical cohort (N = 110), we identified that patients with FGFR1+ tumors were more likely to have progesterone receptor (PR)-negative disease (47% vs. 20%; P = 0.005), coexisting TP53 mutations (41% vs. 21%; P = 0.05), and exhibited shorter time to progression with endocrine therapy alone and in combination with CDK4/6 inhibitor, but not with a mTOR inhibitor (everolimus), adjusting for key prognostic variables in multivariate analysis. Furthermore, mTOR-based therapy resulted in a sustained radiological and molecular response in an index case of FGFR1+ HR+/HER2− MBC. In preclinical models, estrogen receptor–positive (ER+)/FGFR1-amplified CAMA1 human breast cancer cells were only partially sensitive to fulvestrant, palbociclib, and alpelisib, but highly sensitive to everolimus. In addition, transduction of an FGFR1 expression vector into ER+ T47D cells induced resistance to fulvestrant that could be overcome by added TORC1 inhibition, but not PI3K or CDK4/6 inhibition.

Conclusions:
Collectively, these findings suggest that while FGFR1 amplification confers broad resistance to ER, PI3K, and CDK4/6 inhibitors, mTOR inhibitors might have a unique therapeutic role in the treatment of patients with ER+/FGFR1+ MBC.
Cervical Spinal Involvement in a Chinese Pedigree With Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy Caused by a 3′ Untranslated Region Mutation of
COL4A1
Gene
Authors: Zhao Yu-Ying , Duan Ruo-Nan , Ji Lin , Liu Qi-Ji , Yan Chuan-Zhu 
Published: August 2019

Background and Purpose—

Pontine autosomal dominant microangiopathy and leukoencephalopathy, a recently defined subtype of cerebral small vessel disease, is associated with mutations in
COL4A1
(collagen type IV alpha 1 chain) 3′ untranslated region. We here describe a pontine autosomal dominant microangiopathy and leukoencephalopathy pedigree with
COL4A1
mutation presenting both pontine and cervical spinal cord involvement.

Methods—
For the diagnostic purpose, brain and spinal magnetic resonance imaging scanning, skin biopsy, and whole-exome sequencing were performed on the patients in the pedigree. Suspected pathogenic variants were further confirmed by cosegregation analysis using Sanger sequencing in the family members.

Results—

We identified a mutation located at the binding site of miR-29 (microRNA-29) in 3′ untranslated region of
COL4A1
(c.*32G>A). The pontine autosomal dominant microangiopathy and leukoencephalopathy patients in this pedigree carried this variant, whereas other healthy family members but one did not. Magnetic resonance imaging showed lesions in the pons, white matter, and cervical spinal cord. Skin biopsy revealed thickened basal lamina in vessels.

Conclusions—
For the first time, we reported cervical spinal involvement in pontine autosomal dominant microangiopathy and leukoencephalopathy and expanded the clinical spectrum of this disease
Global Assessment of Semidiurnal Internal Tide Aliasing in Argo Profiles
Authors: Hennon Tyler D. , Alford Matthew H. , Zhao Zhongxiang 
Published: August 2019

AbstractThough unresolved by Argo floats, internal waves still impart an aliased signal onto their profile measurements. Recent studies have yielded nearly global characterization of several constituents of the stationary internal tides. Using this new information in conjunction with thousands of floats, we quantify the influence of the stationary, mode-1 M2 and S2 internal tides on Argo-observed temperature. We calculate the in situ temperature anomaly observed by Argo floats (usually on the order of 0.1°C) and compare it to the anomaly expected from the stationary internal tides derived from altimetry. Globally, there is a small, positive correlation between the expected and in situ signals. There is a stronger relationship in regions with more intense internal waves, as well as at depths near the nominal mode-1 maximum. However, we are unable to use this relationship to remove significant variance from the in situ observations. This is somewhat surprising, given that the magnitude of the altimetry-derived signal is often on a similar scale to the in situ signal, and points toward a greater importance of the nonstationary internal tides than previously assumed.
Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries
Authors: Ohlsson Lena , Haanes Kristian A , Kronvall Erik , Xu Cen , Snellman Josefin , Edvinsson Lars 
Published: August 2019

Background Calcitonin gene-related peptide (CGRP) is a neuronal transmitter present in intracranial sensory nerves, where it is involved in migraine pathophysiology as well as other biological functions. Recently, the fully human monoclonal antibody erenumab (AMG 334), which targets the canonical calcitonin gene-related peptide receptor, showed significant prophylactic efficacy and favourable safety in phase II and III clinical trials for episodic and chronic migraine and is now approved for migraine prevention in several countries. Objective Given that calcitonin gene-related peptide can mediate vasodilation, we investigated the effect of erenumab on vasoactive responses in the presence or absence of various vasodilatory and vasocontractile mediators in a model using isolated human cerebral and meningeal arteries. Methods Ring segments of human isolated cerebral and meningeal arteries were mounted in a sensitive myograph. On arterial segments pre-contracted with 30 mM potassium chloride, vasoactive responses to calcitonin gene-related peptide were studied in the presence of different concentrations of erenumab. At the maximal tested inhibitory concentration of erenumab (100 nM), functional arterial relaxation in response to nicardipine or substance P, and the contractile responses to sumatriptan and dihydroergotamine were examined. Results 30 mM potassium chloride produced a stable contraction of the vessel segments and calcitonin gene-related peptide induced a concentration-dependent relaxation. We observed that (i) erenumab had no direct contractile or relaxant effects per se (by itself), (ii) pre-treatment with erenumab antagonized the calcitonin gene-related peptide-induced relaxation in a competitive manner, (iii) the relaxant responses to nicardipine or substance P were unaffected in the presence of erenumab and (iv) the contraction induced by sumatriptan or dihydroergotamine was not modified by erenumab. Conclusion Our findings demonstrate that erenumab, while not associated with vasoactive properties per se, specifically inhibits calcitonin gene-related peptide-induced relaxation of cranial arteries without impacting vasodilatory responses or contractile responses of endogenous or pharmacological vasoactive compounds.