bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN KARAKTER SENSORIS DAN EKONOMI PADA KERUPUK SAYUR
Authors: Kawiji Kawiji 
Published: July 2019

<p>Kerupuk sayur adalah kerupuk dengan bahan-bahan wortel, bayam dan jagung manis, dengan demikian kerupuk sayur ini merupakan kerupuk yang mengandung berbagai zat gizi dan vitamin. Kandungan sayuran inilah yang menjadikan kerupuk sayur ini sebagai makanan camilan yang bermanfaat bagi kesehatan. Tujuan<br />penelitian ini memunculkan produk olahan baru berbasis karbohidrat dan sayuran berbentuk kerupuk yang memiliki nilai tambah vitamin, protein dan kandungan zat besi. Produk baru sebagai kerupuk sayur yang dirancang praktis ini, diharapkan mampu meningkatkan diversifikasi produk sayuran sehingga menjadi produk<br />olahan yang siap konsumsi. Pembuatan kerupuk sayur terdiri dari beberapa tahap, yaitu sortasi, penimbangan, pemblanchingan, penghalusan bumbu-bumbu, pembuatan adonan, pengukusan, pendinginan, pencetakan, pengeringan,<br />penggorengan dan pengemasan. Dari perbandingan t hitung dan t tabel diketahui bahwa warna, kenampakan, aroma, rasa pedas dan rasa asin dari kedua jenis kerupuk adalah sama, sedangkan tekstur dan keseluruhannya berbeda. Dari uji ranking dan skoring kerupuk sayur dengan jagung manis lebih disukai sehingga kerupuk sayur yang akan diproduksi adalah kerupuk sayur dengan penambahan jagung manis dan selanjutnya jenis kerupuk ini yang dianalisis ekonominya. <br />Biaya produksi yang digunakan dalam pembuatan kerupuk sayur sebesar Rp Rp 296.676,1 per hari dan laba bersih yang diperoleh sebesar Rp 55.006,6 per hari dengan kapasitas produksi kerupuk sayur setiap hari adalah 17,6 kg dengan harga Rp 2.000 per 100 gram (1 bungkus). Berdasarkan perhitungan kelayaan usaha<br />diperoleh Break Even Point (BEP) produksi sebesar 148,3 bungkus (148 bungkus), yang artinya pada tingkat produksi sebanyak 148 bungkus akan menghasilkan titik impas. Besarnya Return of Invesment (ROI) sebelum pajak yaitu 18,65 % dan ROI sesudah pajak yaitu 18,54 %. <br />Kata Kunci: karakter sensoris, kerupuk sayur, evaluasi ekonomi</p>
KARAKTERISTIK FISIKO-KIMIA DAN SENSORI VELVA PEPAYA (Carica papaya L.) DENGAN PEMANIS MADU
Authors: Rahmawati Suci , Nurhartadi Edhi , Ishartani Dwi 
Published: July 2019

<p>Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi konsentrasi madu sebagai pengganti sukrosa terhadap karakteristik fisik, kimia, dan sensori velva pepaya. Penelitian ini menggunakan pola Rancangan Acak Lengkap (RAL) dengan satu faktor yaitu konsentrasi pemanis madu. Konsentrasi pemanis madu yang digunakan 5-15%. Dilakukan pengulangan sampel sebanyak dua kali dan tiga kali pengulangan analisa. Data yang diperoleh pada pengujian fisik, kimia, sensori dianalisis menggunakan one way ANOVA pada tingkat α = 0,05. Jika terdapat perbedaan nyata, maka dilanjutkan dengan uji Duncan Multiple Range Test<br />(DMRT) pada α= 0,05. Untuk data yang diperoleh dari uji Intensitas Tingkat Kemanisan, jika ada perbedaan nyata dilanjutkan dengan uji Tukey. Hasil penelitian yang diperoleh penggunaan pemanis madu meningkatkan<br />serat pangan, vitamin C, β-karoten, aktivitas antioksidan, daya leleh, dan total padatan terlarut, serta menurunkan kadar air dan overrun velva pepaya yang dihasilkan. Penggunaan pemanis madu berpengaruh nyata terhadap<br />karakteristik sensori yaitu menurunkan tingkat kesukaan panelis pada parameter warna, rasa, aroma, tekstur, dan overall velva pepaya. Uji intensitas tingkat kemanisan diketahui bahwa velva pepaya dengan 5% pemanis madu<br />memiliki tingkat kemanisan lebih rendah dari velva pepaya dengan 20% pemanis sukrosa, velva pepaya dengan 10% pemanis madu memiliki tingkat kemanisan sama dengan velva pepaya dengan 20% pemanis sukrosa dan velva pepaya dengan 15% pemanis madu memiliki tingkat kemanisan lebih tinggi dari velva pepaya dengan 20% pemanis sukrosa.</p><p><br />Kata kunci: madu, sukrosa, velva papaya</p>
KARAKTERISTIK FISIKOKIMIA TEPUNG KACANG TURI BERBUNGA PUTIH (Sesbania grandiflora) DENGAN BEBERAPA PERLAKUAN PENDAHULUAN
Authors: Ishartani Dwi , Affandi Dian Rachmawanti , Purnamasari Dessy Cahya 
Published: July 2019

<p>Tujuan penelitian ini adalah mempelajari pengaruh perlakuan pendahuluan terhadap sifat kimia (abu, lemak, protein, asam fitat, dan asam sianida) serta sifat fisik (derajat putih, densitas kamba, dan kelarutan) tepung kacang turi berbunga putih. Penelitian ini menggunakan rancangan acak lengkap dengan satu faktor,<br />yaitu perlakuan pendahuluan yang meliputi: kontrol (F1), perebusan 90 menit dengan kulit (F2), perendaman 24 jam dengan kulit (F3), pengupasan kulit (F4), perebusan 90 menit kupas kulit (F5) dan perendaman 24 jam kupas kulit (F6). Hasil penelitian menunjukkan bahwa seluruh perlakuan pendahuluan menghasilkan tepung dengan kadar abu, asam fitat dan asam sianida (HCN) yang lebih rendah dibandingkan kontrol. Perlakuan pendahuluan pengupasan baik dengan maupun tanpa perebusan 90 menit dan perendaman 24 jam (F4, F5, F6) menghasilkan tepung dengan kadar lemak dan kadar protein lebih tinggi dibandingkan kontrol. Perebusan 90 menit dan perendaman 24 jam menghasilkan tepung dengan kadar lemak dan protein lebih rendah dibandingkan kotrol baik yang dikupas maupun yang tidak dikupas kulitnya (F2, F3, F5, F6). Tepung dengan kadar lemak dan<br />protein tertinggi yaitu tepung dengan perlakuan pendahuluan pengupasan kulit (F4) dan tepung dengan kadar lemak dan protein terendah yaitu tepung dengan perlakuan pendahuluan perendaman 24 jam tanpa pengupasan kulit (F2). Penurunan kadar asam fitat dan asam sianida terbesar terjadi pada perlakuan pendahuluan perebusan 90 menit disertai pengupasan kulit (F5) sedangkan yang terkecil pada perlakuan pendahuluan pengupasan kulit (F4). Secara umum, perlakuan pendahuluan menurunkan densitas kamba dan kelarutan tepung yang dihasilkan, kecuali tepung dengan perlakuan pendahuluan 24 jam tanpa pengupasan kulit (F2) yang memiliki densitas kamba yang tidak berbeda nyata dengan kontrol. Derajat putih tepung dengan berbagai perlakuan pendahuluan<br />cukup variatif, yang paling tinggi derajat putihnya adalah tepung dengan perlakuan pendahuluan pengupasan kulit (F4) dan yang paling rendah adalah tepung dengan perlakuan pendahuluan perendaman 24 jam tanpa pengupasan kulit (F2). <br />Kata kunci : pengupasan kulit, perebusan, perendaman, sifat kimia, tepung kacang turi berbunga putih</p>
The anti-neoplastic effect of Doxycycline in Osteosarcoma as a Metalloproteinase (MMP)-inhibitor. A systematic review
Authors: Hadjimichael Argyris Costas , Foukas Athanasios Fotios , Savvidou Olga D. , Mavrogenis Andreas F. , Psyrri Amanda K. , Papagelopoulos Panagiotis J. 
Published: July 2019

Abstract
ABSTRACT

Background
Osteosarcoma is as a very aggressive primary bone tumor, affecting mainly young populations. Most cases diagnosed have distant macro and micro-metastases at the time of diagnosis. Surgical resection with neoadjuvant and adjuvant therapies improve overall and disease-free survival of patients. Doxycycline, a synthetic tetracycline has been found to act either as an antibiotic drug as well as a chemotherapeutic agent. Its anti-neoplastic role has been proven to be extremely significant in various types of cancer like prostate, intestinal, central neural system cancers and osteosarcoma. Inhibition of metalloproteinases (MMPs) in different stages of tumor expansion is the most well understood mechanism. MMPs are secreted molecules from various normal cells like fibroblasts, leucocytes and vascular smooth muscles but also from cells with high proliferative potential like tumor cells. In osteosarcoma, MMPs have been found to be overexpressed. MMPs help osteosarcoma cells to survive, grow and give metastases in distant sites, mainly in lungs. Doxycycline, blocks extracellular matrix and basic membranes degradation by suppressing MMPs function. As a consequence, osteosarcoma cells lose their ability to invade and give metastases. Additionally, doxycycline eliminates the secretion of vascular endothelial growth factor (VEGF) and deprives the supply of circulating nutritious components, by its anti-angiogenesis action. The aim of this review is to evaluate doxycycline’s action against osteosarcoma cells as an MMP-inhibitor and interpret its usage as a chemotherapeutic agent.
Methods
We checked PubMed and Google Scholar for recent published data, on the tumor-supportive role of MMPs and VEGF in osteosarcoma cells. We further studied published experimental trials, on the role of doxycycline as a tumor-suppressive agent via MMPs and VEGF inhibition.
Results
MMPs and VEGF have been found to play a fundamental role in osteosarcoma cells survival and its high aggressiveness by in vitro, in vivo and clinical trials. Nevertheless, Doxycycline proved its tumor-suppressive effect, by in vivo experimental trials in various cancers, but not yet in osteosarcoma.
Conclusion
Doxycycline remains a promising chemotherapeutic agent against osteosarcoma, via MMPs inhibition, showing of the need, for further in vivo and clinical trials to carried out in the future.
Key Words: Osteosarcoma, Metalloproteinase, VEGF, Doxycycline, Metastasis
Pathological staging of chorioamnionitis comtributes to complications in preterm infants
Authors: Miao Jiayu , Ren Zhuxiao , Rao Yunbei , Xia Xin , Zhang Qi , Xu Fang , Zhang Xiaoling , Yang Jie 
Published: July 2019

Abstract
【Abstact】
Objective: To investigate the effect of pathological staging of chorioamnionitis (CA) on complications in preterm infants;
Methods: A single-center, retrospective study was conducted to choose singleton preterm infants in our hospital from December 2016 to December 2017. The basic data and placental pathological results were retrospectively collected. The patients were divided into 4 groups according to the placental pathological results, the incidence of common complications in preterm infants in each group was compared, and analyzed the influence of pathological staging of CA on the complications. Further, CA 0/I phase was combined into non-amnitis group, CA II/III phase was combined into amnitis group, gestational age and birth weight were corrected, logistic regression was used to analyze the effects on complications whether inflammation infiltrated amnion according to odds ratio (OR) value.
Results: A total of 221 preterm infants were enrolled, including 84 cases of non-chorioamnionitis(CA0), 102 cases of CAI, 30 cases of CAII, and 5 cases of CAIII. The gestational age of CA II and III groups was lower than CA 0 and I, birth weight was lower than that of CA 0 and I, and the hospital stay in CA II and III was longer (P<0.05); The incidence of intraventricular hemorrhage（IVH） in CAII/III group (26.7%, 60.0%) was higher than that in CA 0 and I (15.5%, 9.8%)(P = 0.007),and the early-onset IVH was more common(P=0.021). CA 0, I was divided into non-amnitis group according to whether the inflammation infiltrated the amniotic layer ( placental fetal surface), CA II and III were divided into amnitis group, and the risk of IVH increased by amnitis(OR= 3.248, P value <0.05), and after correction of gestational age and birth weight, the risk of it still increased (OR = 3.236, P value <0.05), the difference was statistically significant.
Conclusion: Intrauterine inflammation leads to a significant reduction in gestational age and birth weight in preterm infants ,and it is also an independent risk factor for increasing the incidence of IVH;
Intra-tumoural estrogen sulfotransferase (hSULT1E1) regulations in human breast cancer tissues are influenced by cellular redox-modifications through antioxidants and Nrf-2/NFκβ interplay.
Authors: nazmeen aarifa , Chen Guangping , Ghosh Tamal Kanti , maiti smarajit 
Published: July 2019

Abstract
Background: Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Reports reveal a potential redox-regulation of hSULT1E1/ E2-signalling. Further, oxidatively-regulated nuclear-receptor-factor 2 (Nrf2) and NFκβ in relation to hSULT1E1/E2 could be therapeutic-target via cellular redox-modification. Methods: Here, oxidative stress-regulated SULT1E1-expression was analyzed in human breast carcinoma-tissues and in rat xenografted with human breast-tumor. Tumor and its surrounding tissues were obtained from the district-hospital. Intracellular redox-environment of tumors was screened with some in-vitro studies. RT-PCR and western blotting was done for SULT1E1 expression. Immunohistochemistry was performed to analyze SULT1E1/Nrf2/NFκβ localization. Tissue-histoarchitechture/DNA-stability (comet assay) studies were done. Results: Oxidative-stress induces SULT1E1 via Nrf2/NFκβ cooperatively in tumor-pathogenesis to maintain the required proliferative-state under enriched E2-environment. Higher malondialdehyde/non-protein-soluble-thiol with increased superoxide-dismutase/Glutathione-peroxidase/catalase activities was noticed. SULT1E1 expression and E2-level were increased in tumor-tissue compared to their corresponding surrounding-tissues. Conclusions: It may be concluded that tumors maintain a sustainable oxidative-stress through impaired antioxidants as compared to the surrounding. Liver-tissues from xenografted rat manifested similar E2/antioxidant dysregulations favoring pre-tumorogenic environment.
Diagnosis and Treatment of Abdominal Extra- Gastrointestinal Stromal Tumors
Authors: He Yu , Rao Hua-Min , Ji She-Qing , Yu Yu-Jun , Zhou Qiao-Miao , Wang Cheng , Wang Rong-Jian , He Jian-Bo , Han Shao-Liang 
Published: July 2019

Abstract
Background: To investigate the clinicopathological features and treatment outcome of abdominal extra-gastrointestinal stromal tumors (EGISTs).
Methods: The clinicopathological data and follow-up results of 22 patients with abdominal EGISTs proved by pathology were reviewed retrospectively.
Results: The main symptoms were abdominal mass in 14 cases, abdominal distention and pain in 6, detected by healthy screening in one, spontaneous rupture of tumor and intra-abdominal hemorrhage in one. The tumor locations were retroperitonum in 11 cases, mesentery in 6, and greater momentum in 3, liver in one and pancreas in one, and the tumor size<5cm in one case, 5-10cm in 9 and >10cm in 12. The immunochemistry stain revealed that the positive rate of CD117 was 95.5%, CD34 36.4%, DOG-1 13.6%, SMA 4.5%, and S-100 protein 4.5%.
The resection rate was 81.8% (18/22 cases), including tumor resection in 16, an irregular hepatectomy in one, a distal pancreactomy in one, and simple laparotomy with biopsy in 4. The radicality of operation was R0 resection in 14 cases, R1 resection in 2 and R2 resection in 2. Eleven cases (50.0%) in this group received imatinib adjuvant treatment, including administration greater than 1 year in 6 cases, and greater than 3 years in 5.
The 1, 3, 5-year overall survival rates in the study were 88.9% (16/18 cases), 72.2% (13/18), and 55.6% (10/21), respectively. Among them, 72.7% (8/11), 45.5% (5/11) and 45.5% (5/11) were for retroperitoneal tumors, respectively; and 100.0% (6/6), 100.0% (6/6) and 66.7% (4/6) for mesentery EGIST, respectively.
Conclusions: Abdominal EGISTs have a high potential of malignancy, the surgery is the choice of the treatment, and the postoperative adjuvant treatment with imatinib may improve the survival rate of high-risk cases.
[Key words] Extra-gastrointestinal stromal tumor;
Abdomen; Surgical treatment; Imatinib
Apoptosis and Necrosis on T47D Cells Induced by Shiga-Like Toxin from Local Isolates of Escherichia coli O157:H7
Authors: Suardana I Wayan - , Sudisma I Gusti Ngurah - , Pinatih Komang Januartha Putra , Widiasih Dyah Ayu 
Published: July 2019

Abstract
Background

Apoptosis and cell cycle arrest induction are targeted in the strategy of cancer therapy. Furthermore, bacterial toxins such as Shiga-like toxin producing Escherichia coli have been suggested to be used as a novel therapeutic agent against tumor malignancies, either as independent anti-neoplastic agents, or in combination treatment with chemo or radiotherapy. The aim of study was to investigate the potency of Shiga-like toxin originating from local strains of E. coli O157:H7 which was known less toxic than ATCC 43894 as a new cancer therapy.

Methods

As many as 10 culture cells T47D cell line were subjected by crude extract Shiga-like toxin originating from five local isolates of E. coli O157:H7 with each codes KL-48(2), SM-25(1), SM-7(1), DS-21(4), and one isolate ATCC 43894 as a control with IC50 doses, respectively. The treatment was observed for 24 h, with two replications. An FITC-Annexin V and PI assay was used to observe apoptosis and necrosis effect, and simultaneously with cell cycle analysis using propidium iodide (PI) staining.

Results

The study shown that T47D cells treated with Shiga-like toxin from local strain KL-48 (2) show the lowest viable cell, followed by SM7(1), ATCC 43894, SM-25(1), DS-21(4) in contrary with the control cells with each percentages at 15.20, 16.36, 22.17, 22.64, 33.86, and 94.36%, respectively. The results were also confirmed by the induction of the cell cycle arrest in phase G0-G1 as inactive phase, i.e. 66.41, 63.37, 61.52, 55.36 and 47.28% for T47D cells treated with toxins of KL-48(2), ATCC 43894, SM 25(1), SM 7(1), and DS 21(4), respectively.

Conclusions

These results show tendency deleterious effect of Shiga-like toxin from local isolates on T47D cells, so It is concluded that they have potency as a good anticancer drug against Gb3-expressing breast cancer.
A clinical example of the management of a premature baby born after IFV
Authors: Druzhinina N. A. , Merzlyakova D. R. , Shiryaeva G. P. 
Published: July 2019

Babies born through in vitro fertilization (IVF) treatment are most often born preterm [1]. Most authors state that these children are more likely to have congenital malformations, bronchopulmonary dysplasia (BPD), hypoxic central nervous system damage, hyperbilirubinemia. It is known that these children are 6 times more likely to have an extremely low birth weight and intrauterine growth retardation [2]. More than 35 years have passed since the birth of the first child through the IVF treatment. During this time, the assisted reproductive technologies have improved and therewith the number of children conceived in vitro has also increased. In this regard, the issues relating to the study of the health of children conceived through IVF treatment are growing more urgent. In the Russian Federation, the share of premature babies averages 6–8% among all newborns. Children born prematurely should always be in the center of attention of pediatricians, since it is among them that the highest percentage of perinatal pathology is observed and deviations in subsequent development are detected much more often [3].Objective of the study: to study the state of health of a premature baby in the first year of life born through IVF. Material and methods: the researchers performed a continuous, documentary, retrospective analysis of the medical history of a child treated in the Special Care Nursery of the City Children’s Clinical Hospital in Ufa, and afterwards monitored the child in the Catamnesis Unit. The child underwent clinical examination, assessment of physical development using the centile method, laboratory tests, analysis of primary medical documentation (hospital neonatal record f. 097/u, outpatient medical record f. 112/u). The premature baby was examined taking into account the adjusted age (from the calendar age to 40 weeks of gestation).Results: the health and age of the mother are crucial in forming the health of the child. The mother had a combined pathology. The 3rd pregnancy (the 1st pregnancy ended in childbirth at 35 weeks, the child grows in a family, the 2nd pregnancy ended in spontaneous abortion) through IVF treatment developed against the threat of interruption starting from 8 weeks, combined gestosis, grade 1B placental violation, low placentation, isthmic-cervical insufficiency (ICI), antiphospholipid syndrome, which resulted in early, premature birth at 29 weeks’ gestational age. The child was born prematurely with perinatal nervous system damage, the development of acute pneumonia, respiratory distress syndrome of the newborn.Findings: A clinical case determines the need for targeted observation of a premature child from a risk group, timely advanced training of a pediatrician regarding the features of management of premature babies born through the IVF treatment, taking into account the adjusted age.
Influence of adherence to medical recommendations on symptom control in children with bronchial asthma
Authors: Zastrozhina A. K. , Zakharova I. N. , Sychev D. A. 
Published: July 2019

The search for factors affecting the efficacy of bronchial asthma (BA) therapy in children is an actual problem. subject of many modern scientific studies. Authors note that adherence to therapy in patients with asthma ranges from 30 to 70%. Often this index does not exceed 50%. Analysis of adherence to medical recommendations in children with asthma and the search for compliance reduction factors is one of the ways for optimizing therapy and improving the quality of life for children with asthma.Purpose. In order to optimize bronchial asthma therapy in pediatric practice, we analysed adherence to medical recommendations and its effect on the controllability of the disease in children with asthma.Materials and methods. The study included 94 children aged 6 to 17 years with an established diagnosis of bronchial asthma. All patients had previously been recommended basic therapy in the form of inhaled glucocorticosteroids (ICS) or their fixed combinations with long-acting beta2-adrenomimetikami (LABA). An assessment of BA control symptoms was carried out, and factors affecting adherence to medical recommendations were analyzed. The effect of decreased patient compliance on the control of asthma symptoms was evaluated.Results. 61.7% of children with asthma have insufficient disease control. In 42.55% of patients, a survey revealed insufficient adherence to medical recommendations. 88.3% of children and their parents reported the presence of factors capable of influencing the decrease in compliance. The most frequently occurring factor in reducing adherence to therapy turned out to be insufficient patient awareness of the disease itself, the mechanisms of therapy action, and the prospect of treatment. Statistical data processing showed a statistically significant decrease in adherence to medical recommendations in the group of patients with insufficient asthma symptom control (p = 0.038).Conclusion. Only 38.3% of children had complete asthma symptom control. The statistically significant reduction in adherence to medical recommendations in the group of children with insufficient symptom control suggests the need for educational activities for children with BA and their parents in order to increase adherence to medical recommendations, optimize the effectiveness of therapy and improve the quality of patients’ life.