bluuebunny/crossref_metadata_2025_split huggingface dataset:
The UK Stewardship Code and investee earnings quality
Authors: Lu Chun , Christensen Jacqui , Hollindale Janice , Routledge James 
Published: July 2018

PurposeThe UK Stewardship Code was the first voluntary governance code specifically for institutional investors. The Code sets out the principles of effective stewardship by institutional investors toward their investee companies with the aim of improving long-term risk-adjusted returns to shareholders. This paper aims to examine whether compliance by institutional investors with UK Stewardship Code is related to the earnings quality of their investee companies.Design/methodology/approachThe association between institutional investor Code compliance and Code compliance quality and investee company accruals quality is investigated.FindingsFor a sample of large UK listed companies from 2013, the authors find reasonably high levels of compliance with the Code by institutional investors. The analysis does not suggest that Code compliance is positively related to investee company earnings quality. Rather, the finding is that substantial or long-term investments are more likely to result in effective stewardship regardless of Code compliance.Originality/valueThis study offers valuable insights regarding the efficacy of the Stewardship Code’s policy approach to improving corporate governance by institutional investors.
Performance measurement and management systems as IT artefacts
Authors: Marchand Marie , Raymond Louis 
Published: July 2018

Purpose
Considering performance measurement and management systems (PMMS) to be “mission-critical” information systems for many business organisations, calls have been made for researchers to shift from studying the use of such systems to studying their “effective” use, and in so doing to focus on their characterisation as information technology (IT) artefacts. The paper aims to discuss this issue.

Design/methodology/approach
In seeking to answer these calls, the authors apply Burton-Jones and Grange’s theoretical framework to study the dimensions, contextual drivers and benefits of the effective use of PMMS. This is done through a field study of 16 PMMS artefacts as used in small- and medium-sized enterprises (SMEs).

Findings
In characterising, contextualising and valuing the effective use of PMMS, this study provides answers to the following questions: What constitutes the effective use of PMMS? What are the user, artefactual and task-related drivers of such use? And what are the benefits for SMEs of using performance measurement and management (PMM) systems effectively?

Practical implications
With regard to the design of a PMMS artefact, the findings imply that one should concentrate on those artefactual attributes that most enable informed action on the part of owner-managers, as it is these actions have the greater consequences for the realisation of IT business value in SMEs. Moreover, the nomological network resulting from this research provides the theoretical and methodological underpinnings of a diagnostic tool meant to develop the PMM function in SMEs.

Originality/value
This study provides further empirical grounding and understanding. This study provides further empirical grounding and understanding of the concept of effective use, as well as further applicability and actionability to this concept and to the nomological network of its dimensions, contextual drivers and benefits in the case of PMMS and in the context of SMEs.
Women’s football studies: an integrative review
Authors: Valenti Maurizio , Scelles Nicolas , Morrow Stephen 
Published: July 2018

Purpose
Women’s football has received increasing attention in the academic literature, partly due to its growing popularity worldwide. However, women’s football research remains scattered across numerous academic domains. Focusing on the social sciences, humanities and management disciplines, the purpose of this paper is to map and organise contributions, and to identify research directions for future studies within these disciplines.

Design/methodology/approach
Using the keywords “women”, “girls”, “female” and “football” or “soccer” to initially identify articles, an integrative approach was followed to evaluate and analyse relevant literature. In all, 117 academic journals were classified and subsequently divided into 26 themes according to the subject area, topic and level examined.

Findings
Results of this integrative review show an increasing trend of journal publications since 1998, with a large representation of studies related to historical and sociological research, where qualitative methods are dominant. Articles investigating economic, managerial and marketing areas appeared in more recent times. Women’s football has been researched from different perspectives (players, fans, sport organisations) and across various countries.

Research limitations/implications
The restricted scope of this review (i.e. its focus on social sciences) and the manual classification of articles represent two limitations of this study. However, the synthesis of academic literature provided may assist scholars who are interested in women’s football and women’s sports research to fill identified research gaps and contribute to further advance academic investigations in this area.

Originality/value
This paper provides an overview of salient research avenues and represents the first attempt to critically appraise the direction of academic contributions in women’s football for the purpose of advancing scholarly inquiry in this sport.
Mind wandering, together with test anxiety and self‐efficacy, predicts student's academic self‐concept but not reading comprehension skills
Authors: Desideri Lorenzo , Ottaviani Cristina , Cecchetto Carla , Bonifacci Paola 
Published: July 2018

BackgroundMind wandering (MW) has commonly been linked to bad scholastic performance; however, such association has rarely been investigated in the classroom. Moreover, in examining such association, motivational variables have been largely ignored.AimWe aimed at examining the associations between the dispositional tendency to engage in MW and a series of reading comprehension skills and measures of academic self‐concept above and beyond the role of sex, age, test anxiety, self‐efficacy, and self‐regulation strategies.SampleLate adolescents (N = 272, 133 females; 17.23 ± 1.10 years) recruited from 15 classes in public high schools.MethodsStudents were examined in their classroom during regular teaching activities and first performed a reading comprehension test. Then, they underwent a battery assessing literacy skills, academic self‐concept, the dispositional tendency to mind wander, and aspects related to self‐regulated learning.ResultsReading comprehension and literacy skills (decoding, orthographic awareness, spelling skills, and phonological abilities) were not associated with the tendency to mind wander. Instead, MW, test anxiety, and self‐efficacy – but not self‐regulatory strategies – were independent predictors of academic self‐concept.ConclusionsThis study highlights the importance of evaluating the effects of MW on academic self‐concept, taking into account a complex pattern of motivational and emotional variables.
Clinical profile of gilteritinib in Japanese patients with relapsed/refractory acute myeloid leukemia: An open‐label phase 1 study
Authors: Usuki Kensuke , Sakura Toru , Kobayashi Yukio , Miyamoto Toshihiro , Iida Hiroatsu , Morita Satoshi , Bahceci Erkut , Kaneko Masahito , Kusano Mikiko , Yamada Shunsuke , Takeshita Shigeru , Miyawaki Shuichi , Naoe Tomoki 
Published: July 2018

Gilteritinib, a novel, highly specific, potent fms‐like tyrosine kinase 3/AXL inhibitor, demonstrated antileukemic activity in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML). In this open‐label phase 1 study (NCT02181660), Japanese patients (aged ≥18 years) with R/R AML received once‐daily gilteritinib, escalating from 20 to 300 mg/d. Primary endpoints were safety/tolerability, including the maximum tolerated dose (MTD) and the recommended dose (RD); secondary endpoints were antileukemic activity and pharmacokinetics (PK). Twenty‐four Japanese patients with R/R AML received once‐daily oral gilteritinib in 1 of 6 dose‐escalation cohorts (20, 40, 80, 120, 200, and 300 mg/d). Gilteritinib was well tolerated. The MTD was 200 mg/d; dose‐limiting toxicities were grade 3 tumor lysis syndrome (120 mg/d; n = 1); and grade 3 elevated blood lactate dehydrogenase, amylase, blood creatine phosphokinase levels, and syncope (all n = 2; 300 mg/d). The RD was 120 mg/d. The most common drug‐related grade ≥3 adverse events were thrombocytopenia (n = 4 [16.7%]) and increased blood creatine phosphokinase (n = 3 [12.5%]). Gilteritinib had a dose‐proportional PK profile. Among patients with mutated fms‐like tyrosine kinase 3, the overall response rate (ORR) was 80% (n = 4 of 5; complete remission [CR] with incomplete platelet recovery, 1 [20%]; CR with incomplete hematologic recovery, 2 [40%]; partial remission (PR), 1 [20%]). Among patients with wild‐type fms‐like tyrosine kinase 3, ORR was 36.4%; (n = 4 of 11; CR, 1 [9.1%]; CR with incomplete platelet recovery, 2 [18.2%]; PR, 1 [9.1%]). In conclusion, gilteritinib was well tolerated and demonstrated antileukemic activity in a Japanese R/R AML population.
Injury among children and young people with and without attention‐deficit hyperactivity disorder in the community: The risk of fractures, thermal injuries, and poisonings
Authors: Prasad Vibhore , West Joe , Sayal Kapil , Kendrick Denise 
Published: July 2018

AbstractBackgroundInjuries commonly cause morbidity and mortality in children and young people (CYP). Attention‐deficit hyperactivity disorder (ADHD) is the commonest neurobehavioural disorder in CYP and is associated with increased injury risk. However, large, population‐based estimates of the risk of specific injuries are lacking. We aimed to provide estimates of the risk of fractures, thermal injuries, and poisonings in CYP with and without ADHD.MethodsIn this population‐based cohort study, we used primary and secondary care medical records from England from the Clinical Practice Research Datalink. There were 15,126 CYP with ADHD frequency‐matched to 263,724 without, aged 3–17 years at diagnosis. The risk of (a) fractures, (b) thermal injuries, and (c) poisonings in CYP with ADHD was compared with those without.ResultsThe absolute rate of injury per thousand person‐years at risk in CYP with versus without ADHD was fracture 28.9 (95% CI [27.5, 30.3]) versus 18.7 (95% CI [18.5, 19.0]), long bone fracture 17.7 (95% CI [16.7, 18.8]) versus 11.8 (95% CI [11.6, 12.0]), thermal injuries 4.4 (95% CI [3.9, 4.9]) versus 2.2 (95% CI [2.1, 2.3]), and poisonings 6.3 (95% CI [5.7, 6.9]) versus 1.9 (95% CI [1.9, 2.0]). Adjusting for age, sex, geographical region, deprivation, and calendar year, CYP with ADHD had 25% increase in risk of fracture (hazard ratio [HR] = 1.25; 95% CI [1.19, 1.31]), 21% increase in risk of long bone fracture (HR = 1.21; 95% CI [1.13, 1.28]), double the risk of thermal injury (HR = 2.00; 95% CI [1.76, 2.27]), and almost four times the risk of poisoning (HR = 3.72; 95% CI [3.32, 4.17]).ConclusionsCYP with ADHD are at greater risk of fracture, thermal injury, and poisoning compared with those without. Paediatricians and health care professionals should provide injury prevention advice at diagnosis and reviews.
Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy
Authors: Kong Tingting , Hao Liying , Wei Yuanyuan , Cai Xiaoxiao , Zhu Bofeng 
Published: July 2018

AbstractObjectivesCarbon dots (CDs) are one of the most promising carbon‐based materials in bioimaging and drug/gene delivery applications. In this study, we have attempted to study the drug carrying capacity of highly fluorescent CDs for delivery of doxorubicin (DOX) and investigate the therapeutic activity of the CDs‐DOX drug delivery system.Materials and methodsCarbon dots were synthesized by means of a hydrothermal approach with mixing citric acid and ethylenediamine. The properties of CDs were characterized in respects of spectral property, zeta potential, particle morphology and chemical composition. The drug loading efficiency (DLE) and release profile of CDs‐DOX were determined by a fluorescence spectrophotometer. We investigated the cellular toxicity and pharmaceutical activity of CDs and CDs‐DOX in L929 cells and MCF‐7 cells by the CCK‐8 assay. We also studied the cellular uptake of CDs‐DOX with the methods of confocal microscopy and flow cytometry. In addition, the effect of CDs‐DOX on cell apoptosis was assessed by flow cytometry.ResultsThe obtained CDs possessed good biocompatibility and showed a potential capacity of promoting proliferation. DOX was successfully conjugated to CDs through electrostatic interaction, and the results of the DLE and loading content (DLC) suggested a relatively high drug loading capacity of CDs. Compared with free DOX, the CDs‐DOX complex had a higher cellular uptake and better anti‐tumour efficacy on MCF‐7 cells.ConclusionsThe results of this study indicated that the CDs‐DOX drug delivery system had a potential value in cancer chemotherapeutic application.
Enhanced thalamo‐hippocampal synchronization during focal limbic seizures
Authors: Aracri Patrizia , de Curtis Marco , Forcaia Greta , Uva Laura 
Published: July 2018

SummaryObjectiveThe key factors that promote the termination of focal seizures have not been fully clarified. The buildup of neuronal synchronization during seizures has been proposed as one of the possible activity‐dependent, self‐limiting mechanisms. We investigate if increased thalamo‐cortical coupling contributes to enhance synchronization during the late phase of focal seizure‐like events (SLEs) generated in limbic regions.MethodsRecordings were simultaneously performed in the nucleus reuniens of the thalamus, in the hippocampus and in the entorhinal cortex of the isolated guinea pig brain during focal bicuculline‐induced SLEs with low voltage fast activity at onset.ResultsSpectral coherence and cross‐correlation analysis demonstrated a progressive thalamo‐cortical entrainment and synchronization in the generation of bursting activity that characterizes the final part of SLEs. The hippocampus is the first activated structure at the beginning of SLE bursting phase and thalamo‐hippocampal synchronization is progressively enhanced as SLE develops. The thalamus takes the lead in generating the bursting discharge as SLE end approaches.SignificanceAs suggested by clinical studies performed during pre‐surgical intracranial monitoring, our data confirm a role of the midline thalamus in leading the synchronous bursting activity at the end of focal seizures in the mesial temporal regions.
HORMAD2 methylation‐mediated epigenetic regulation of gene expression in thyroid cancer
Authors: Lin Qiuyu , Hou Sen , Guan Feng , Lin Chenghe 
Published: July 2018

AbstractThis study is aimed to investigate the methylation level of candidate genes and its impact on thyroid carcinoma (THCA) development. Infinium Human Methylation 450 BeadChip Arrays by Illumina (Illumina HM450K) was the most popular CpG microarray platform widely used in biological and medical research. The methylation level of differentially expressed genes and their corresponding CpG sites were analysed by R programme. The expression of HORMAD2 was evaluated by qRT‐PCR and Western blot, while the methylation level was examined via methylation‐specific PCR. Cell viability, metastasis, cell cycle and apoptosis were detected by MTT assay, transwell and wound healing assay and flow cytometry, respectively, after treatment with 5‐aza‐2′‐deoxycytidine (5‐Aza). Tumour formation assay was used to analyse thyroid tumour growth in nude mice in vivo. The methylation levels of all 116 differentially expressed genes were analysed. HORMAD2 was significantly hypermethylated and its mRNA expression was inhibited in THCA cells. After treatment with 5‐Aza, HORMAD2 expression was up‐regulated in THCA cells and its overexpression can suppress thyroid cancer cell viability, mobility and invasiveness remarkably. Up‐regulation of HORMAD2 in THCA cells could prolong G0/G1 phase and shorten S phase to impede cell mitosis as well as promote thyroid cancer cells apoptosis. Furthermore, tumour formation assay showed that increased HORMAD2 level impeded tumour growth in vivo. Hypermethylation of HORMAD2 could induce THCA progression, while hypomethylation of HORMAD2 retard cell growth and mobility and facilitate apoptosis through increasing its mRNA expression.
Replacement reactions and deformation by dissolution and precipitation processes in amphibolites
Authors: Giuntoli Francesco , Menegon Luca , Warren Clare J. 
Published: July 2018

AbstractThe deformation of the middle to lower crust in collisional settings occurs via deformation mechanisms that vary with rock composition, fluid content, pressure, and temperature. These mechanisms are responsible for the accommodation of large tectonic transport distances during nappe stacking and exhumation. Here, we show that fracturing and fluid flow triggered coupled dissolution–precipitation and dissolution–precipitation creep processes, which were responsible for the formation of a mylonitic microstructure in amphibolites. This fabric is developed over a crustal thickness >500 m in the Lower Seve Nappe (Scandinavian Caledonides). Amphibolites display a mylonitic foliation that wraps around albite porphyroclasts appearing dark in panchromatic cathodoluminescence (CL). The albite porphyroclasts were dissected and fragmented by fractures preferentially developed along the (001) cleavage planes and display lobate edges with embayments and peninsular features. Two albite/oligoclase generations, bright in CL, resorbed and overgrew the porphyroclasts, sealing the fractures. Electron backscattered diffraction shows that the two albite/oligoclase generations grew both pseudomorphically and topotaxially at the expense of the albite porphyroclasts and epitaxially around them. These two albite/oligoclase generations also grew as neoblasts elongated parallel to the mylonitic foliation. The amphibole crystals experienced a similar microstructural evolution, as evidenced by corroded ferrohornblende cores surrounded by ferrotschermakite rims that preserve the same crystallographic orientation of the cores. Misorientation maps highlight how misorientations in amphibole are related to displacement along fractures perpendicular to its c‐axis. No crystal plasticity is observed in either mineral species. Plagioclase and amphibole display a crystallographic preferred orientation that is the result of topotaxial growth on parental grains and nucleation of new grains with a similar crystallographic orientation. Amphibole and plagioclase thermobarometry constrains the mylonitic foliation development to the epidote amphibolite facies (˜600°C, 0.75–0.97 GPa). Our results demonstrate that at middle to lower crustal levels, the presence of H2O‐rich fluid at grain boundaries facilitates replacement reactions by coupled dissolution–precipitation and favours deformation by dissolution–precipitation creep over dislocation creep in plagioclase and amphibole.
Outpatient preoperative oral nutritional support for undernourished surgical patients: A systematic review
Authors: van Noort Harm H.J. , Ettema Roelof G.A. , Vermeulen Hester ,  Huisman‐de Waal Getty ,   the Basic Care Revisited Group (BCR)
Published: July 2018

AbstractAims and objectivesTo evaluate the effects of preoperative nutritional support using a regular diet for undernourished surgical patients at the outpatient clinic.BackgroundUndernutrition (or malnutrition) in surgical patients has severe consequences, that is, more complications, longer hospital stay and decreased quality of life. While systematic reviews show the effects of oral nutritional supplements (ONS), enteral and parenteral nutrition in surgical patients, the effects of normal foods and regular diets remain unclear.DesignA systematic review.MethodsPubMed, CINAHL, Web of Science, PsycINFO, Cochrane Library and EMBASE were searched up to July 24, 2017. Studies on undernourished patients receiving nutritional support using regular or therapeutic diet, performed preoperatively at the outpatient clinic, were considered eligible. Risk of bias was assessed using the Cochrane Risk of Bias tool. Two reviewers independently performed study selection, quality assessment and data extraction.ResultsSix studies with moderate risk of bias were included. Interventions were preoperatively performed in mainly oncological outpatients by dieticians and aimed to reach nutrient requirements. Interventions included consults for counselling and advice, follow‐up meetings and encouragements, and ONS. Nutritional status, nutrient intake and quality of life improved in supported patients. Improvements were better in counselled patients compared to patients using supplements. Unsupported patients experienced worse outcomes.ConclusionFrequent consults with counselling and advice as nutritional support for undernourished patients before surgery result in improvements to nutritional status, intake and quality of life. This statement is supported by weak evidence due to few studies and inadequate methods.Relevance to clinical practiceNutritional support should be provided to all undernourished surgical patients during preoperative course. Nurses are in key position to provide nutritional support during outpatient preoperative evaluations.
The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton
Authors: Blair Kris M. , Mears Kevin S. , Taylor Jennifer A. , Fero Jutta , Jones Lisa A. , Gafken Philip R. , Whitney John C. , Salama Nina R. 
Published: July 2018

SummaryChronic infection with Helicobacter pylori can lead to the development of gastric ulcers and stomach cancers. The helical cell shape of H. pylori promotes stomach colonization. Screens for loss of helical shape have identified several periplasmic peptidoglycan (PG) hydrolases and non‐enzymatic putative scaffolding proteins, including Csd5. Both over and under expression of the PG hydrolases perturb helical shape, but the mechanism used to coordinate and localize their enzymatic activities is not known. Using immunoprecipitation and mass spectrometry we identified Csd5 interactions with cytosolic proteins CcmA, a bactofilin required for helical shape, and MurF, a PG precursor synthase, as well as the inner membrane spanning ATP synthase. A combination of Csd5 domain deletions, point mutations, and transmembrane domain chimeras revealed that the N‐terminal transmembrane domain promotes MurF, CcmA, and ATP synthase interactions, while the C‐terminal SH3 domain mediates PG binding. We conclude that Csd5 promotes helical shape as part of a membrane associated, multi‐protein shape complex that includes interactions with the periplasmic cell wall, a PG precursor synthesis enzyme, the bacterial cytoskeleton, and ATP synthase.