bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les préparatifs d’un hackathon recherche : au coeur de la fabrique des données
Authors: Gruson-Daniel Celya , de Quatrebarbes Constance 
Published: December 2018

Depuis les années 2010, de nouveaux formats de recherche tels que leshackathonset lesdata sprintsse sont développés dans le cadre d’expérimentations en sociologie numérique. Sur un temps très court, ces événements proposent d’analyser des données numériques ou numérisées et d’en présenter les premiers résultats. Or, on observe que ces « formats courts » relèguent souvent dans l’ombre la phase de préparation de ces données pour se concentrer sur l’exploration et la visualisation de jeux de données. En tant que coordonnatrices d’un hackathon recherche portant sur la consultation République numérique, nous avons observé les préparatifs à l’oeuvre dans l’organisation d’un tel événement. Des observations qui mettent en lumière un important travail de fabrication des données. De leur collecte à leur mise à disposition le jour de l’événement, ces étapes invisibilisées par ces « formats courts » révèlent un ensemble d’enjeux politiques autour de cesdataet de leur ouverture, qui se dessinent même dans les choix techniques opérés par les acteurs en présence.
Recombinant yeast VDAC2: a comparison of electrophysiological features with the native form
Authors: Magrì Andrea , Karachitos Andonis , Di Rosa Maria Carmela , Reina Simona , Conti Nibali Stefano , Messina Angela , Kmita Hanna , De Pinto Vito 
Published: December 2018

Voltage‐dependent anion channel isoform 2 of the yeast Saccharomyces cerevisiae (yVDAC2) was believed for many years to be devoid of channel activity. Recently, we isolated yVDAC2 and showed that it exhibits channel‐forming activity in the planar lipid bilayer system when in its so‐called native form. Here, we describe an alternative strategy for yVDAC2 isolation, through heterologous expression in bacteria and refolding in vitro. Recombinant yVDAC2, like its native form, is able to form voltage‐dependent channels. However, some differences between native and recombinant yVDAC2 emerged in terms of voltage dependence and ion selectivity, suggesting that, in this specific case, the recombinant protein might be depleted of post‐translational modification(s) that occur in eukaryotic cells.
Comparison of different registration landmarks for MRI‐CT fusion in radiotherapy for lung cancer with post‐obstructive lobar collapse
Authors: Han Qian , Liang Hengpo , Cheng Peng , Shi Dapeng 
Published: December 2018

AbstractThe registration of the two sets of images based on the spine and pulmonary artery landmarks and the geometric center difference of the mean displacement in the X, Y, and Z directions (X, Y, and Z represent the directions of the body from left to right, superior to inferior, and anterior to posterior) between their MRI‐CT fusions were compared, respectively. Fifty‐five lung cancer patients with post‐obstructive lobar collapse were enrolled in this study. Before radiation, two sets of simulating images according to the spine and the pulmonary artery registrations were obtained for each patient using MRI‐CT fusion. The differences of mean displacement in the X, Y, and Z directions based on spine and pulmonary artery landmarks were of −0.29, 0.25, and 0.18 cm, respectively. The mean displacements of the pulmonary artery based images in the three directions were smaller than that in the spine registration images (P < 0.05). By the method of pulmonary artery landmark, MRI‐CT has better registration accuracy and can better help confirm the target volume.
Ultrathin Non‐van der Waals Magnetic Rhombohedral Cr2S3: Space‐Confined Chemical Vapor Deposition Synthesis and Raman Scattering Investigation
Authors: Zhou Shasha , Wang Renyan , Han Junbo , Wang Deli , Li Huiqiao , Gan Lin , Zhai Tianyou 
Published: December 2018

AbstractTwo dimensional (2D) magnetic materials display enormous application potential in spintronic fields. However, most of currently reported magnetic materials are van der Waals layered structure that is easy to be isolated via exfoliation method. By contrast, the studies on non‐van der Waals ultrathin magnetic materials are rare, largely due to the difficulty in fabrication. Rhombohedral Cr2S3, an intensively studied antiferromagnetic transition metal chalcogenide with Neel temperature of ≈120 K, has a typical non‐van der Waals structure. Restricted by the strong covalent bonding in all the three dimensions of non‐van der Waals structure, the synthesis of ultrathin Cr2S3 single crystals is still a challenge that is not achieved yet. Besides, the study on the Raman modes of rhombohedral Cr2S3 is also absent. Herein, by employing space‐confined chemical vapor deposition strategy, ultrathin rhombohedral Cr2S3 single crystals with a thickness down to ≈2.5 nm for the first time are successfully grown. Moreover, a systematically investigation is also conducted on the Raman vibrations of ultrathin rhombohedral Cr2S3. With the aid of angle‐resolved polarized Raman technique, the Raman modes of rhombohedral Cr2S3 for the first time based on crystal symmetry and Raman selection rules are rationally assigned.
High Modulus Conductive Hydrogels Enhance In Vitro Maturation and Contractile Function of Primary Cardiomyocytes for Uses in Drug Screening
Authors: Wu Fengxin , Gao Aijun , Liu Jian , Shen Yaoyi , Xu Panpan , Meng Jie , Wen Tao , Xu Lianghua , Xu Haiyan 
Published: December 2018

AbstractEffective and quick screening and cardiotoxicity assessment are very crucial for drug development. Here, a novel composite hydrogel composed of carbon fibers (CFs) with high conductivity and modulus with polyvinyl alcohol (PVA) is reported. The conductivity of the composite hydrogel PVA/CFs is similar to that of natural heart tissue, and the elastic modulus is close to that of natural heart tissue during systole, due to the incorporation of CFs. PVA/CFs remarkably enhance the maturation of neonatal rat cardiomyocytes (NRCM) in vitro by upregulating the expression of α‐actinin, troponin T, and connexin‐43, activating the signaling pathway of α5 and β1 integrin‐dependent ILK/p‐AKT, and increasing the level of RhoA and hypoxia‐inducible factor‐1α. As a result, the engineered cell sheet–like constructs NRCM@PVA/CFs display much more synchronous, stable, and robust beating behavior than NRCM@PVA. When exposed to doxorubicin or isoprenaline, NRCM@PVA/CFs can retain effective beating for much longer time or change the contractile rate much faster than NRCM@PVA, respectively, therefore representing a promising heart‐like platform for in vitro drug screening and cardiotoxicity assessment.
Intracellular Delivery of His‐Tagged Genome‐Editing Proteins Enabled by Nitrilotriacetic Acid–Containing Lipidoid Nanoparticles
Authors: Li Yamin , Li Alice Chukun , Xu Qiaobing 
Published: December 2018

AbstractProtein‐ and peptide‐based therapeutics with high tolerance and specificity along with low off‐target effects and genetic risks have attracted tremendous attention over the last three decades. Herein, a new type of noncationic lipidoid nanoparticle (LNP) is reported for His‐tagged protein delivery. Active lipidoids are synthesized by conjugating a nitrilotriacetic acid group with hydrophobic tails (EC16, O16B, and O17O) and nanoparticles are formulated in the presence of nickel ions and helper lipids (cholesterol, 1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine, and 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000]). It is demonstrated that the newly developed LNPs are capable of delivering various His‐tagged proteins including green fluorescent protein (GFP), (−30)GFP‐Cre recombinase, and CRISPR/Cas9 ribonucleoprotein into mammalian cells.
Minimally Invasive and Regenerative Therapeutics
Authors: Ashammakhi Nureddin , Ahadian Samad , Darabi Mohammad Ali , El Tahchi Mario , Lee Junmin , Suthiwanich Kasinan , Sheikhi Amir , Dokmeci Mehmet R. , Oklu Rahmi , Khademhosseini Ali 
Published: December 2018

AbstractAdvances in biomaterial synthesis and fabrication, stem cell biology, bioimaging, microsurgery procedures, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics, herein defined as cells, biomaterials, biomolecules, and their combinations, can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Sophisticated methods of tracking, sensing, and stimulation of therapeutics in vivo using nano‐biomaterials and soft bioelectronic devices provide great opportunities to further develop minimally invasive and regenerative therapeutics (MIRET). In general, minimally invasive delivery methods offer high yield with low risk of complications and reduced costs compared to conventional delivery methods. Here, minimally invasive approaches for delivering regenerative therapeutics into the body are reviewed. The use of MIRET to treat different tissues and organs is described. Although some clinical trials have been performed using MIRET, it is hoped that such therapeutics find wider applications to treat patients. Finally, some future perspective and challenges for this emerging field are highlighted.
Doping of Carbon Materials for Metal‐Free Electrocatalysis
Authors: Hu Chuangang , Dai Liming 
Published: December 2018

AbstractCarbon atoms in the graphitic carbon skeleton can be replaced by heteroatoms with different electronegative from that of the carbon atom (i.e., heteroatom doping) to modulate the charge distribution over the carbon network. The charge modulation can be achieved via direct charge transfer with an electron acceptor/donor (i.e., charge transfer doping) or through introduction of defects (i.e., defective doping). Various doping strategies, including heteroatom doping, charge‐transfer doping, and defective doping, have now been devised for modulating the charge distribution of numerous graphite carbon materials to impart new properties to carbon materials. Consequently, carbon nanomaterials with defined doping have recently become prominent members in the carbon family, promising for a variety of applications, including catalysis, energy conversion and storage, environmental remediation, and important chemical production and industrial processes. The purpose of this review is to present an overview on the doping of carbon materials for metal‐free electrocatalysis, especially the development of doping strategies and doping‐induced structure and property changes for potential catalytic applications. Current challenges and future perspectives in the doped carbon‐based metal‐free catalyst field are also discussed.
Pd‐Decorated CuO Thin Film for Photodegradation of Acetaminophen and Triclosan under Visible Light Irradiation
Authors: Katal Reza , Panah Saeid Masudy , Saeedikhani Mohsen , Kosari Mohammadreza , Sheng Chua Chin , Leong Ong Say , Xiao Gong , Jiangyong Hu 
Published: December 2018

AbstractInefficient visible light photocatalytic degradation of organic pollutants, such as acetaminophen (ACE) and triclosan (TS), is one of the main limiting factors for implementing cost‐effective metal oxide photocatalyst for large‐scale deployment. Here, a highly efficient CuO thin film photocatalyst is developed through rapid thermal annealing. The CuO thin film is decorated with Pd nanostructures for enhanced visible light degradation of ACE and TS. It is shown that compared to the as‐deposited thin CuO film photocatalyst, the rapid thermal assisted CuO photocatalyst can significantly enhance charge generation and separation efficiency through improvement of crystallinity and reduction of recombination centres. Furthermore, it is demonstrated that the incorporation of Pd nanostructures can considerably increase optical absorption, which further improve the photocatalytic performance through the enhancement of surface plasmon resonance. The CuO film with the 40 s of Pd sputtering (Pd40–CuO) shows the highest performance for photocatalytic degradation of both ACE and TS. The Pd40–CuO film shows good stability and does not show any considerable reduction in photocatalytic activity after five cycles. This indicates the high potential of Pd40–CuO for water and wastewater treatment on industrial scale.
Nanoparticle Assembled Mesoporous MoO2 Microrods Derived from Metal Organic Framework and Wrapped with Graphene as the Sulfur Host for Long‐Life Lithium–Sulfur Batteries
Authors: Razaq Rameez , Sun Dan , Xin Ying , Li Qian , Huang Taizhong , Zhang Zhaoliang , Huang Yunhui 
Published: December 2018

AbstractLithium–sulfur (Li–S) batteries are highly potential for next‐generation electrochemical energy storage due to their high energy density. However, low conductivity of the sulfur cathode, dissolution, and poor conversion kinetics of lithium polysulfides (LiPSs) are the key challenges. Herein crispy rice‐like nanoparticle assembled mesoporous MoO2 microrods derived from metal organic frameworks and wrapped with graphene (MoO2/rGO) are fabricated, exhibiting high electron and lithium ion conductivity from the inherent metallic conductivity for MoO2 and mesoporous‐structural microrod morphology, physical confinement for LiPSs through mesopores, chemical adsorption, and catalytic conversion of LiPSs by formation of thiosulfates (polythionates) due to moderate redox potential for MoO2. The S‐MoO2/rGO cathode shows a discharge capacity of 1145 mAh g−1 at 0.5C and keeps at 1027 mAh g−1 after 500 cycles, corresponding to an average capacity decay rate of 0.02% per cycle. Specifically, an ultralong cycling life with a low capacity decay of 0.016% only over 3200 cycles at 3.0C is the best performance in long‐life Li–S batteries among reported sulfur hosts.
Domino Synthesis of 3‐Alkyliden‐2,3‐Dihydro‐4‐Quinolones
Authors: Raga Esther , Escolano Marcos , Torres Javier , Rabasa‐Alcañiz Fernando , Sánchez‐Roselló María , del Pozo Carlos 
Published: December 2018

AbstractThe synthesis of 3‐alkyliden‐2,3‐dihydro‐4‐quinolones has been accomplished in a domino fashion through a three‐step sequence that comprised an initial aza‐Baylis‐Hillman reaction, followed by a 1,3‐rearrangement and an intramolecular amination. Starting from readily available aryl vinyl ketones and N‐tosyl imines, the reaction with PPh3, CsOAc and CuI in CH3CN gave rise, in good overall yields, to final 3‐alkyliden‐4‐quinolone derivatives, valuable scaffolds in medicinal chemistry. The simultaneous addition of two bases, PPh3 and CsOAc, was found to be crucial for the success of the process. While PPh3 promoted the reversible aza‐Baylis‐Hillman reaction, CsOAc triggered the subsequent 1,3‐rearrangement, which shifted the initial equilibrium and allowed to complete the synthetic sequence upon the addition of CuI.magnified image
Copper‐Catalyzed Intermolecular Hydroamination of Arylamines or Aza‐Heterocycles with Nitrostyrene Derivatives
Authors: Park Subin , Kang Seongil , Lee Yunmi 
Published: December 2018

AbstractA new copper‐catalyzed protocol for the intermolecular anti‐Markovnikov addition of arylamines or heterocycles to terminal and unsymmetrical 1,2‐disubstituted vinylarenes has been developed. The direct hydroamination is catalyzed by a readily available N‐heterocyclic carbene‐based copper complex and KOt‐Bu, and the use of MeOH as an additive enhances the reactivity. The method provides a broad range of new and versatile amine compounds bearing various functional groups in good to excellent yields.magnified image
Dual‐Gate Organic Field‐Effect Transistor for pH Sensors with Tunable Sensitivity
Authors: Pfattner Raphael , Foudeh Amir M. , Chen Shucheng , Niu Weijun , Matthews James R. , He Mingqian , Bao Zhenan 
Published: December 2018

AbstractDual‐gate field‐effect transistors (FETs) based on organic semiconductor polymer and SiOx as the topmost active sensing layer permit monitoring of pH in physiologically relevant conditions in a fast and reversible fashion. Beyond that, due to the bottom gate‐induced field effect, such sensors exhibit tunable sensitivity and provide faster continuous measurements compared to conventional bulky glass bulb pH sensors. pH response of bare SiOx is evaluated independently by means of voltmeter measurements. When assembled in dual‐gate architecture, the pH response of FET devices scales in agreement with the theoretical model, which assumes capacitive coupling, exhibiting an amplification of up to 10. This opens up the possibility for reversible and reliable sensing based on organic semiconductors well beyond pH sensors.
Thermodynamic and Kinetic Origins of Ferroelectricity in Fluorite Structure Oxides
Authors: Park Min Hyuk , Lee Young Hwan , Mikolajick Thomas , Schroeder Uwe , Hwang Cheol Seong 
Published: December 2018

AbstractFerroelectricity in fluorite structure oxides such as HfO2 and ZrO2 has been intensively studied since the first report on it in 2011. The ferroelectricity in this material system is induced by the formation of a non‐centrosymmetric orthorhombic phase, which is not thermodynamically stable under the normal thin‐film processing conditions. Therefore, the thermodynamic and kinetic origins of the formation of the ferroelectric phase have yet to be clearly elucidated. Here, the previously proposed thermodynamic model based on the surface/interface/grain boundary energy argument is critically reviewed, and it is concluded that the thermodynamic model could not account for the emergence of the metastable phase accurately. Subsequently, the probable kinetic paths of phase evolution during the crystallization annealing and cooling processes are reassessed. A phase transition in Hf1−xZrxO2 thin films can be considered a feasible example of the well‐known Ostwald's step rule involving a two‐step phase transition with different kinetic energy barriers. It is concluded that the emergence of the ferroelectric orthorhombic phase can be mainly attributed to a kinetic origin: the transition to a stable nonferroelectric monoclinic phase either from the tetragonal or orthorhombic phase, which must be initially formed during the crystallization anneal, is kinetically suppressed.
Silver Telluride Nanowire Assembly for High‐Performance Flexible Thermoelectric Film and Its Application in Self‐Powered Temperature Sensor
Authors: Zeng Xiaoliang , Yan Changzeng , Ren Linlin , Zhang Tao , Zhou Fengrui , Liang Xianwen , Wang Ning , Sun Rong , Xu Jian‐Bin , Wong Ching‐Ping 
Published: December 2018

AbstractFlexible thermoelectric materials that enable harvesting electricity from human body heat or an ambient temperature gradient have potential applications in self‐powered flexible wearable electronics. The development of more efficient and flexible n‐type thermoelectric materials, however, is highly desired but challenging. Herein, reported is a nylon substrate supported fabric silver telluride (Ag2Te) nanowire network used as flexible n‐type thermoelectric materials, by the combination of vacuum filtrated assembly and mechanical pressing method. The prepared silver telluride nanowire films show optimal thermoelectric properties with the Seebeck coefficient of −129.5 µV K−1 and electrical conductivity of 187.78 S cm−1, leading to the highest power factor of 315.1 µW m−1 K2. Owing to the elimination of Peierls stress in the fabrics interlocking structure, the silver telluride nanowire films exhibit good flexibility, as the thermoelectric properties only have a change below 10% after 500 bending cycles. Based on the silver telluride nanowire film, a flexible self‐powered temperature sensor is fabricated for detecting the temperature from a human finger. The sensor shows high sensitivity that its response time and reset time are about 1.05 and 2.1 s, respectively. The results imply that silver telluride nanowire films have great potential applications in flexible thermoelectric energy conversion and self‐powered temperature sensing.
Deaminative (Carbonylative) Alkyl‐Heck‐type Reactions Enabled by Photocatalytic C−N Bond Activation
Authors: Jiang Xuan , Zhang Mao‐Mao , Xiong Wei , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: December 2018

AbstractThe palladium‐catalyzed Heck reaction is a well‐known, Nobel Prize winning transformation for producing alkenes. Unlike the alkenyl and aryl variants of the Heck reaction, the alkyl‐Heck reaction is still underdeveloped owing to the competitive side reactions of alkyl–palladium species. Herein, we describe the development of a deaminative alkyl‐Heck‐type reaction that proceeds through C−N bond activation by visible‐light photoredox catalysis. A variety of aliphatic primary amines were found to be efficient starting materials for this new process, affording the corresponding alkene products in good yields under mild reaction conditions. Moreover, this strategy was successfully applied to deaminative carbonylative alkyl‐Heck‐type reactions.
Late‐Stage Diversification through Manganese‐Catalyzed C−H Activation: Access to Acyclic, Hybrid, and Stapled Peptides
Authors: Kaplaneris Nikolaos , Rogge Torben , Yin Rongxin , Wang Hui , Sirvinskaite Giedre , Ackermann Lutz 
Published: December 2018

AbstractBioorthogonal C−H allylation with ample scope was accomplished through a versatile manganese(I)‐catalyzed C−H activation for the late‐stage diversification of structurally complex peptides. The unique robustness of the manganese(I) catalysis manifold was reflected by full tolerance of sensitive functional groups, such as iodides, esters, amides, and OH‐free hydroxy groups, thereby setting the stage for the racemization‐free synthesis of C−H fused peptide hybrids featuring steroids, drug molecules, natural products, nucleobases, and saccharides.
Interconverting Lanthanum Hydride and Borohydride Catalysts for C=O Reduction and C−O Bond Cleavage
Authors: Patnaik Smita , Sadow Aaron D. 
Published: December 2018

AbstractThe high catalytic reactivity of homoleptic tris(alkyl) lanthanum La{C(SiHMe2)3}3 is highlighted by C−O bond cleavage in the hydroboration of esters and epoxides at room temperature. The catalytic hydroboration tolerates functionality typically susceptible to insertion, reduction, or cleavage reactions. Turnover numbers (TON) up to 10 000 are observed for aliphatic esters. Lanthanum hydrides, generated by reactions with pinacolborane, are competent for reduction of ketones but are inert toward esters. Instead, catalytic reduction of esters requires activation of the lanthanum hydride by pinacolborane.
The Cardiac Gap Junction has Discrete Functions in Electrotonic and Ephaptic Coupling
Authors: Gourdie Robert G. 
Published: December 2018

ABSTRACTConnexin43‐formed gap junctions have long been thought to contribute to cardiac conduction in the mammalian ventricle by providing direct electrotonic connectivity between the cytoplasms of neighboring cardiomyocytes. However, accumulating data from studies of non‐mammalian hearts, Connexin 43 (Cx43) knockout mice and human Cx43 mutations have raised questions as to whether gap junctions are the sole means by which electrical coupling between cardiomyocytes is accomplished. Computational and experimental work over the last decade have indicated that intercellular propagation of action potentials in the heart may involve both electrotonic and ephaptic contributions—in what has been dubbed “mixed‐mode” conduction. Interestingly, the Cx43 gap junction may provide a common structural platform in mammals that facilitates the operation of these two mechanisms. In addition to gap junction channels functioning in an electrotonic role, the perinexus region at the edge of gap junctions may be provide a niche for voltage‐gated sodium channels from neighboring cells to be in sufficiently close proximity to enable ephaptic transmission of action potential. A novel role has recently been identified in this potential ephaptic mechanism for inter‐membrane adhesion mediated by the beta subunit (beta1/Scn1b) of the sodium channel. The new perspective of the operational redundancy that is built into cardiac electrical connectivity could provide new understanding of arrhythmia mechanisms and holds the promise for new approach to anti‐arrhythmic therapy. Anat Rec, 302:93–100, 2019. © 2018 Wiley Periodicals, Inc.