bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Elderly Behavior Monitoring Technology Based on WSN and Neural Network
Authors: Lieping Zhang , Zhengzhong Wang , Zhenyu Yang , Rui Wang , Kunjian Li , Keying Wei , Shenglan Zhang , Yu Zhang 
Published: September 2019

Background:
The elderly are prone to do some abnormal behaviors, such as tumbling or
stepping out of the guardians’ monitoring area. These abnormal behaviors bring enormous hidden
dangers to the health of the elderly, which need to be monitored effectively in order to be dealt with
in time.

Objective:
Provide an approach based on Wireless Sensor Network (WSN) and Multi-Layer Perceptron
(MLP) to establish the behaviors monitoring system for the elderly.

Methods:
A behavior monitoring system based on wireless sensor network and neural network is
proposed in this paper, according to the behavior characteristics of the elderly. The system collects
real-time behavior data of the elderly by wearing a bracelet with acceleration sensors wore on their
hands. And then a behavior recognition model of the elderly is established through the MLP and the
collected behavior data. The established behavior recognition model is used to classify and identify
the five typical behavior characteristics of the elderly, such as walking, sitting, lying, standing and
tumbling. At the same time, the location information of the elderly is estimated by the centroid
localization technology based on Received Signal Strength Indication (RSSI) ranging.

Results:
The experiment results show that the designed system can timely acquire the behavior
characteristic parameters of the elderly, and it can accurately identify the five typical behaviors with
a 100% recognition accuracy rate. And also, it can timely give the warning of the abnormal
behaviors of the elderly, such as tumbling or walking out of the active area.

Conclusion:
The proposed system in this paper can accurately identify the abnormal behaviors of
elderly and timely inform the guardians. The proposed monitoring method can effectively reduce
the hurt injury elderly, and can improve the work efficiency of guardians. And it has its theoretical
and practical value.
In-silico Design, ADMET Screening, MM-GBSA Binding Free Energy of Some Novel Isoxazole Substituted 9-Anilinoacridines as HER2 Inhibitors Targeting Breast Cancer
Authors: Kalirajan Rajagopal , Pandiselvi Arumugasamy , Gowramma Byran , Balachandran Pandiyan 
Published: September 2019

Background:Human Epidermal development factor Receptor-2 (HER2) is a membrane tyrosine kinase which is overexpressed and gene amplified in human breast cancers. HER2 amplification and overexpression have been linked to important tumor cell proliferation and survival pathways for 20% of instances of breast cancer. 9-aminoacridines are significant DNA-intercalating agents because of their antiproliferative properties.Objective:Some novel isoxazole substituted 9-anilinoacridines(1a-z) were designed by in-silico technique for their HER2 inhibitory activity. Docking investigations of compounds 1a-z are performed against HER2 (PDB id-3PP0) by using Schrodinger suit 2016-2.Methods:Molecular docking study for the designed molecules 1a-z are performed by Glide module, in-silico ADMET screening by QikProp module and binding free energy by Prime-MMGBSA module of Schrodinger suit. The binding affinity of designed molecules 1a-z towards HER2 was chosen based on GLIDE score.Results:Many compounds showed good hydrophobic communications and hydrogen bonding associations to hinder HER2. The compounds 1a-z, aside from 1z have significant Glide scores in the scope of - 4.91 to - 10.59 when compared with the standard Ethacridine (- 4.23) and Tamoxifen (- 3.78). The in-silico ADMET properties are inside the suggested about drug likeness. MM-GBSA binding of the most intense inhibitor is positive.Conclusion:The outcomes reveal that this study provides evidence for the consideration of isoxazole substituted 9-aminoacridine derivatives as potential HER2 inhibitors. The compounds, 1s,x,v,a,j,r with significant Glide scores may produce significant anti breast cancer activity and further in vitro and in vivo investigations may prove their therapeutic potential.
MALATYA YÖRESİ İÇİN ÖRNEK BİR GÜNEŞ SANTRALİ MODELİNİN BENZETİMİ VE ŞEBEKEYE ETKİLERİNİN İNCELENMESİ
Authors: Akdağ Ozan , Yeroğlu Celaleddin 
Published: September 2019

Güneş enerjisi günümüzde soğutma, ısıtma ve elektrik enerjisi elde
etme gibi birçok alanda kullanılmaktadır. Güneş enerjisinin temiz bir yenilenebilir enerji kaynağı oluşu,
ülkemizin güneş enerji potansiyelinin yüksek olması ve 2023 yılı ülkemizin 5000
MW kurulu güneş santrali hedefinin olması, güneş enerjisine ilgiyi artırmaktadır. Güneş santralleri
kurulmadan önce ön çalışmalar yaparak, güneş santrali yapılacak bölgenin
tespiti, ilave edilecek güç sistemine etkileri ve güvenirlikli bir işletme
şartlarının oluşturulması önemlidir. Bu gibi işlemleri önceden öngörmek ve
güneş santralini, güç sistemine en iyi biçimde entegre etmek için modellemeler
yapmak gereklidir. Bu çalışmada Malatya ilinde güneş santrali kurulumu
açısından uygun olan bir bölge ön etüt çalışması yapılarak belirlenip, daha
sonra o bölgeye en yakın 154/34,5 kV transformatör merkezinin 34,5 kV’lık barasına
dâhil edilmesi düşünülen santralin, sanal modeli oluşturulup güç sistemine
etkileri detaylı bir şekilde analiz edilmiştir.
YAKLAŞIK ÇÖZÜM TEKNİKLERİNİ KULLANARAK PLASTİK ENJEKSİYON PROSESİNİN TASARIM METODOLOJİSİ
Authors: KAYABAŞI Oğuz , ÇAKMAK Hüseyin 
Published: September 2019

Bu çalışmada, istatistiksel deney tasarım
yöntemleri kullanılarak hazırlanan deney setine uygun olarak yapılan akış
analizleri ile enjeksiyon parametreleri optimize edilmiştir. Elde edilen
sonuçları değerlendirmek için, ilk olarak istatistiksel deney yazılımı olan
MiniTab vasıtası ile uygun bir regresyon modeli oluşturulmuştur, model
katsayılarının doğruluğunu saptamak için F testi, parametrelerin sonuçlar
üzerindeki etkisini saptamak için ANOVA testi uygulanmıştır. İkinci olarak
süreç, bir hipoteze dayanan değişken yaratılarak, Monte Carlo simülasyonu ile
optimize edilmiştir. Monte Carlo simülasyonu, analitik olarak belirsiz
durumlarda varsayımlara dayanan hesaplamaları yapmak için kullanılır. Kalıp
sıcaklığı, soğutma suyu sıcaklığı, enjeksiyon basıncı gibi işlem parametreleri
sabit değildir. Bu belirsizliği gidermek için süreç hipoteze dayalı değişken
üretmek suretiyle optimize edilmiştir. Son aşamada farklı optimizasyon
yöntemleri kullanılarak elde edilen sonuçlar karşılaştırılarak, hangi yöntemin
daha doğru sonuç verdiği değerlendirilmiştir. Sonuç olarak Monte Carlo simülasyonu ile minimum çarpılma
değeri elde edilmiştir. Sonuç bölümünde yer alan Tablo 7 ve Grafik 1 üzerinden
bu sonuç daha net anlaşılmaktadır. Plastik enjeksiyon işlemi gibi birçok
parametrenin sonuç üzerinde etkin olduğu üretim yöntemleri için yapılacak
optimizasyon çalışmalarında, belirsizlikleri gidermek için hipoteze dayalı rastsal
parametre değerleri ile çalışmak avantaj sağlamaktadır.
Fine-Tuning Bidirectional Encoder Representations From Transformers (BERT)–Based Models on Large-Scale Electronic Health Record Notes: An Empirical Study
Authors: Li Fei , Jin Yonghao , Liu Weisong , Rawat Bhanu Pratap Singh , Cai Pengshan , Yu Hong 
Published: September 2019

BackgroundThe bidirectional encoder representations from transformers (BERT) model has achieved great success in many natural language processing (NLP) tasks, such as named entity recognition and question answering. However, little prior work has explored this model to be used for an important task in the biomedical and clinical domains, namely entity normalization.ObjectiveWe aim to investigate the effectiveness of BERT-based models for biomedical or clinical entity normalization. In addition, our second objective is to investigate whether the domains of training data influence the performances of BERT-based models as well as the degree of influence.MethodsOur data was comprised of 1.5 million unlabeled electronic health record (EHR) notes. We first fine-tuned BioBERT on this large collection of unlabeled EHR notes. This generated our BERT-based model trained using 1.5 million electronic health record notes (EhrBERT). We then further fine-tuned EhrBERT, BioBERT, and BERT on three annotated corpora for biomedical and clinical entity normalization: the Medication, Indication, and Adverse Drug Events (MADE) 1.0 corpus, the National Center for Biotechnology Information (NCBI) disease corpus, and the Chemical-Disease Relations (CDR) corpus. We compared our models with two state-of-the-art normalization systems, namely MetaMap and disease name normalization (DNorm).ResultsEhrBERT achieved 40.95% F1 in the MADE 1.0 corpus for mapping named entities to the Medical Dictionary for Regulatory Activities and the Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT), which have about 380,000 terms. In this corpus, EhrBERT outperformed MetaMap by 2.36% in F1. For the NCBI disease corpus and CDR corpus, EhrBERT also outperformed DNorm by improving the F1 scores from 88.37% and 89.92% to 90.35% and 93.82%, respectively. Compared with BioBERT and BERT, EhrBERT outperformed them on the MADE 1.0 corpus and the CDR corpus.ConclusionsOur work shows that BERT-based models have achieved state-of-the-art performance for biomedical and clinical entity normalization. BERT-based models can be readily fine-tuned to normalize any kind of named entities.
Peritoneal Dialysis Patient Outcomes under the Medicare Expanded Dialysis Prospective Payment System
Authors: Young Eric W. , Kapke Alissa , Ding Zhechen , Baker Regina , Pearson Jeffrey , Cogan Chad , Mukhopadhyay Purna , Turenne Marc N. 
Published: September 2019

Background and objectives
Peritoneal dialysis (PD) use increased in the United States with the introduction of a new Medicare prospective payment system in January 2011 that likely reduced financial disincentives for facility use of this home therapy. The expansion of PD to a broader population and facilities having less PD experience may have implications for patient outcomes. We assessed the impact of PD expansion on PD discontinuation and patient mortality.

Design, setting, participants, & measurements
A prospective cohort study was conducted of patients treated with PD at 90 days of ESKD. Patients were grouped by study start date relative to the Medicare payment reform: prereform (July 1, 2008 to December 31, 2009; n=10,585), interim (January 1, 2010 to December 31, 2010; n=7832), and reform period (January 1, 2011 to December 31, 2012; n=18,742). Patient characteristics and facility PD experience were compared at baseline (day 91 of ESKD). Patients were followed for 3 years for the major outcomes of PD discontinuation and mortality using Cox proportional hazards models.

Results
Patient characteristics, including age, sex, race, ethnicity, rurality, cause of ESKD, and comorbidity, were similar or showed small changes across the three study periods. There was an increasing tendency for patients on PD to be treated in facilities with less PD experience (from 34% during the prereform period being treated in facilities averaging <14 patients on PD per year to 44% in the reform period). Patients treated in facilities with less PD experience had a higher rate of PD discontinuation than patients treated in facilities with the most experience (hazard ratio [HR], 1.16; 95% confidence interval [95% CI], 1.10 to 1.23 for the first versus fifth quintile of PD experience). Nevertheless, the risk of PD discontinuation fell during the late interim period (HR, 0.88; 95% CI, 0.82 to 0.95) and most of the reform period (from HR, 0.85; 95% CI, 0.79 to 0.91 to HR, 0.94; 95% CI, 0.87 to 1.01). Mortality risk was stable across the three study periods.

Conclusions
In the context of expanding PD use and declining facility PD experience, the risk of PD discontinuation fell, and there was no adverse effect on mortality.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_09_12_CJN01610219.mp3
STATISTICAL DESIGN AND DEVELOPMENT OF A LIQUID ORAL FLOATING IN SITU GEL OF METFORMIN HYDROCHLORIDE FOR SUSTAINED RELEASE: PHARMACODYNAMIC AND TOXICITY (HISTOPATHOLOGY) STUDIES
Authors: MATHEWS RASHMI , RAO B. PRAKASH , KONDE ABBULU , S. SUDARSHAN , TAHA NAWRES A. , C. SURESH 
Published: September 2019

Objective: To statistically design, optimize and evaluate a liquid oral, floating in situ gel of metformin hydrochloride (MH) to increase the gastric residence time (the absorption window being the upper part of the duodenum), sustain and modulate the release behavior of the drug. No liquid oral SR formulations of MH are yet available in the market.
Methods: A simple mixing based ionic cross-linking method was used for the formulation. A Two-square Factorial Design was employed and the effect of sodium alginate and three categorical levels of HPMC (K4M, K100M, E50) on the response variables were studied.
Results: The optimized formulation gelled instantaneously in simulated gastric fluid and showed>24 h floating. The drug release in 1h was 37.98 %, followed by a moderate sustained release for 12 h. Pharmacodynamic studies showed a significant reduction in blood glucose levels in Wistar rats. Short term preclinical safety studies revealed no toxicity to pancreatic tissues. On the contrary, faster regeneration of the β cells of the islets of Langerhans was observed with the group treated with the optimized formulation. Stability studies revealed a 2-year shelf life.
Conclusion: An elegant, needle-free, in situ gelling, SR liquid oral of metformin hydrochloride could be developed with drug release modulated as per official specifications for SR formulations of MH. This would be an interesting alternative for geriatric patients who find it difficult to swallow bulky tablets.
DEVELOPMENT AND EVALUATION OF CLOBETASOL–LOADED SOLID LIPID NANOPARTICLES FOR TOPICAL TREATMENT OF PSORIASIS
Authors: REDDY K. RAMESH , SATYANARAYANA S. V. , REDDY V. JAYASANKAR 
Published: September 2019

Objective: The current research was structured to achieve a maximum topical delivery for the drug clobetasol-17-propionate (CP) and to predict the effects of various independent variables like lipid: drug ratio, surfactant, and homogenization time on particulate characters and performance solid lipid nanoparticles (SLNs).
Methods: CP loaded SLNs were formulated by Emulsification–Homogenization method and optimized using 33 full factorial designs (Design-Expert software 11.0). Drug loaded SLNs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in vitro drug release through skin (Franz diffusion cell), drug deposition study and stability.
Results: The optimized formulation (SLNs) attains a minimal Particle size of 133.3±3.66 nm, Poly dispersibility index of 0.179±0.081, % entrapment efficiency of 78.1±1.11 and Zeta potential of-36.2±0.11mV. Skin permeation study of CP loaded SLNs suspension showed prolonged drug release up to 24h. Maximum drug deposition was obtained after developing the drug into SLNs (48.22µg/ml) when compared to the pure drug (19.12µg/ml).
Conclusion: SLNs were promising colloidal particulate carriers by which prolonged drug release and improved skin permeation was achieved for the drug Clobetasol 17- propionate.
DEVELOPMENT OF COSMETIC CREAM CONTAINING A PHARMACEUTICAL COCRYSTAL OF SALICYLIC AND PHENYLALANINE
Authors: PHETMUNG HIRIHATTAYA , SAWATDEE SOMCHAI 
Published: September 2019

Objective: The objective of this present work was to develop the chemical peeling cream containing the synthesized active ingredient pharmaceutical cocrystal of salicylic acid and phenylalanine.
Methods: The salicylic acid and phenylalanine cocrystal (H2Sal·Phe) was synthesized by the solvent evaporation method and characterized by various techniques such as single-crystal X-ray diffraction and Fourier transform infrared spectroscopy. The five formulas of cocrystal cream were prepared. All formulas were then examined and observed for appearance, spreadability, viscosity, pH, homogeneity, SPF test, microbial limit test and stability test.
Results: The (H2Sal·Phe) consists of no zwitterion phenylalanine for the first time. X-ray crystal structure of cocrystal consists of double H2Sal and Phe molecules with stabilized by inter-, intra-molecular and π-π interactions. By using this cocrystal as an active ingredient for cosmetic development, the chemical peeling cream was produced along with the pharmaceutical examinations. The (H2Sal·Phe) formulations were prepared 0-1% and excipients included of jojoba oil, isopropyl myristate, castor oil, glyceryl monostearate cetostearyl alcohol, cyclomethicone (and) dimethicone crosspolymer, vitamin E, white bee's wax, glycerin, PEG 400, xanthan gum, Span 80 and Tween 60. We finally found that the F4 (1% H2Sal·Phe) was the best formulation with suitable physical properties of cream and chemical stable after storage. The results of cell viability show H2Sal·Phe is non-toxic with cell.
Conclusion: The chemical peeling cream containing (H2Sal·Phe) has shown the promising results which are both safe and efficacious peeling agent. Cocrystal (H2Sal·Phe) cream can be used as an alternative choice in whitening skin.
FORMULATION AND EVALUATION OF TELMISARTAN FAST DISSOLVING TABLETS USING JACK FRUIT SEED STARCH AS SUPERDISINTEGRANT
Authors: MUPPARAJU SUNDEEP , SURYADEVARA VIDYADHARA , DOPPALAPUDI SANDEEP , REDDYVALLAM L. C. SASIDHAR , ANNE RAMU , SUNKARA SIVA PRASAD 
Published: September 2019

Objective: The main objective of the current study is to enhance the solubility of Biopharmaceutical Classification System (BCS) Class-II drug Telmisartan using jack fruit seed starch as super disintegrant which increases drug release.
Methods: Starches were extracted using alkali technique using sodium hydroxide at 0.1%, 0.25%, and 0.5% concentrations and water from Jack fruit seed powder. These starches were evaluated for various phytochemical and physicochemical tests. Fast dissolving tablets were prepared using Telmisartan, jack fruit seed starch and Croscarmellose sodium in various concentrations using wet granulation technique. Various pre and post-compression parameters were evaluated along with in vitro drug release studies, characterization studies like Fourier Transform Infra-Red spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and accelerated stability studies.
Results: Phytochemical tests revealed the presence of only starch in all the extracts. The starch prepared from 0.1% sodium hydroxide (JFS2) showed best physicochemical properties. From in vitro dissolution studies, it was observed that formulations F5 and F11 containing 15% w/w of JFS2 and 15% w/w of croscarmellose sodium showed faster disintegration and increased dissolution rate compared with other formulations. FTIR and DSC studies showed that there were no major interactions among drug and excipients. XRD studies revealed the nature of formulations. Accelerated stability studies revealed the stability of tablets.
Conclusion: Thus, the tablets prepared using Jack fruit seed starch revealed the super disintegrant property of starch.
SUPEROXIDE DISMUTASE LOADED NIOSOMES DELIVERY TO HAIR FOLLICLES: PERMEATION THROUGH SYNTHETIC MEMBRANE AND GUINEA PIG SKIN
Authors: KARAMI MASOUD ALI , JALILI RAD MARZIE , ZADEH BEHZAD SHARIF MAKHMAL , SALIMI ANAYATOLLAH 
Published: September 2019

Objective: Alopecia aretea is associated with an increase in free radicals causing damage to hair follicles. Superoxide dismutase (SOD) with sufficient penetration through hair follicles, can prevent their death by its strong antioxidant effects. SOD with high molecular weight underwent limitation in follicular delivery. The aim of this study was the improvement of SOD localization into hair follicles.
Methods: SOD-loaded niosomes were prepared by thin layer hydration method and were used as a vehicle for delivery to hair follicles through guinea pig skin and the synthetic membrane. Particle size, entrapment efficiency, drug release, and permeability parameters through hairly and non-hairly pig skin compared with a synthetic membrane were evaluated.
Results: Niosomes demonstrated 152-325 nm particle size and the SOD burst and sustained release from niosomes were mainly controlled by diffusion and dissolution phenomena. SOD was protected against degradation by niosomes and after six months, enzyme content and activity decreased less than 5%. In comparison with free SOD, niosomes increased SOD affinity to penetration through follicles by interaction with sebum. Likewise, niosome's characters such as type of surfactant, solid lipid/liquid lipid ratio played critical roles on SOD deposition on hair follicles.
Conclusion: Synthetic membrane and hairy guinea pig skin demonstrated similar barrier property against free-SOD thereby implying that free SOD does not interact with guinea pig sebum. Niosomes can introduce a suitable carrier for SOD localization into the hair follicles.
STABILITY INDICATING ULTRA PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF PHENYLEPHRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, PARACETAMOL, GUAIPHENESIN AND BROMHEXINE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATION
Authors: CHENGALVA PRASANTHI , KUCHANA MADHAVI 
Published: September 2019

Objective: The objective of the present study is to develop simple, rapid, sensitive, accurate and economic stability-indicating ultra-performance liquid chromatographic (UPLC) method for the simultaneous quantification of phenylephrine hydrochloride, chlorpheniramine maleate, paracetamol, guaiphenesin and bromhexine hydrochloride in bulk and tablet dosage form.
Methods: The separation of drugs in the chromatographic column was accomplished on Hibar C18 (100 mm x 2.1 mm, 1.6 µm) column at a detection wavelength of 220 nm. The mobile phase was a combination of sodium phosphate monobasic monohydrate buffer (pH was adjusted to 3.5 with orthophosphoric acid) and acetonitrile in the ratio of 70:30 % v/v which was pumped at a flow rate of 0.3 ml/min. The column temperature was maintained at 30 °C and the injection volume was 0.3 µl. Forced degradation studies of drugs were carried out using acid, base, peroxide, light and heat.
Results: All the five drugs have been eluted within 3 min. The retention times were found to be 0.834 min, 1.199 min, 1.600 min, 1.979 min and 2.525 min for phenylephrine, chlorpheniramine maleate, paracetamol, guaiphenesin and bromhexine respectively. The correlation coefficient (r2) was found to be 0.999 for all the drugs. The recovery levels were found to be in the range of 99.17 % to 100.69 %. RSD values of drugs were found to be below 2 %. The results of limit of detection and quantitation specified the sensitivity of the developed method. Significant degradation of drugs as a result of stress studies was found in acid, base and peroxide, but they were slightly degraded in photolytic and thermal conditions. The method has effectively resolved the degraded products. All the validation parameters were found to be within the limits according to International Conference on Harmonization (ICH) guidelines.
Conclusion: A simple and rapid UPLC method was established for the determination of five drugs. Hence, the proposed method can be employed for the quality control of specified drugs in bulk and pharmaceutical formulation even in the presence of degradation products.