bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Spatiotemporal Links Between Meteorological and Hydrological Droughts From a Three‐Dimensional Perspective
Authors: Liu Yi , Zhu Ye , Ren Liliang , Singh Vijay P. , Yong Bin , Jiang Shanhu , Yuan Fei , Yang Xiaoli 
Published: February 2019

AbstractInvestigating the spatiotemporal link among different drought types is of great significance for understanding the causative mechanism of droughts. In this study, we propose a new approach for connecting meteorological and hydrological drought events by considering their overlaps in drought persistence time and spatial coverage in three dimensions (i.e., latitude, longitude, and time). The variable infiltration capacity model with daily hydrometeorological observations in and around the Yellow River basin for the period of 1961–2012 is used to derive the standardized precipitation evapotranspiration index and standardized runoff index. Results show that minor meteorological drought events with short durations and small areas generally are not prone to cause a hydrological drought, especially in winter for the source region, leading to failure matches between the two drought types. By contrast, meteorological droughts of large magnitudes are more likely to influence a hydrological drought in different ways. In three dimensions, the transformation from meteorological to hydrological droughts is characterized by lengthened duration, lagged response time, and attenuated drought severity, which is in accordance with previous studies. Moreover, the drought area also decreases during this process. The increase in potential evapotranspiration from February to April after 1998 is the reason for the attenuation of drought area. The enlarged evaporative demand from potential evapotranspiration aggravates the atmospheric dry condition and promotes the development of meteorological drought but does not necessarily cause a hydrological drought.
Assimilating Every‐10‐minute Himawari‐8 Infrared Radiances to Improve Convective Predictability
Authors: Sawada Yohei , Okamoto Kozo , Kunii Masaru , Miyoshi Takemasa 
Published: February 2019

AbstractImproving the predictability of sudden local severe weather is a grand challenge for numerical weather prediction. Recently, the capability of geostationary satellites to observe infrared radiances has been significantly improved, and it is expected that the “Big Data” from the new generation geostationary satellites could contribute to improving convective predictability. We examined the potential impacts of assimilating frequent infrared observations from a new generation geostationary satellite, Himawari‐8, on convective predictability. We implemented the real‐data experiment in which Himawari‐8 all‐sky moisture‐sensitive infrared radiances of band 8 (6.2 μm) and band 10 (7.3 μm) were assimilated into the high‐resolution (2 km) limited area model, Japan Meteorological Agency's Non‐Hydrostatic Model, every 10 min by the Local Ensemble Transform Kalman Filter. The frequent infrared observations from Himawari‐8 improve the analysis and forecast of isolated convective cells and sudden local severe rainfall induced by weak large‐scale forcing. The results imply that satellite data assimilation can contribute to better forecasting severe weather events in smaller spatiotemporal scales than the previous studies.
Holocene Solar Activity Imprint on Centennial‐ to Multidecadal‐Scale Hydroclimatic Oscillations in Arid Central Asia
Authors: Liu Xiaokang , Rao Zhiguo , Shen Chuan‐Chou , Liu Jianbao , Chen Jianhui , Chen Shengqian , Wang Xianfeng , Chen Fahu 
Published: February 2019

AbstractNumerous studies have been conducted on the Holocene climatic evolution of arid central Asia (ACA) using various geological proxies. However, the quality of the age control and the temporal resolution of the proxy records used make it difficult to characterize hydroclimatic changes on centennial to multidecadal timescales. Here we present a stalagmite δ18O record from Baluk cave in Xinjiang, NW China, in ACA, which has an average 22.8‐year resolution and provides a record of inferred hydroclimatic changes from 8.4 to 2.7 ka. Abrupt hydroclimatic shifts are evident during the following intervals: 2.75–2.90, 3.25–3.35, 3.75–3.85, 4.45–4.55, 4.75–4.90, 5.05–5.15, 5.2–5.3, 5.4–5.5, 5.9–6.0, 6.2–6.3, 6.4–6.5, 6.8–6.9, 7.1–7.6, 7.85–7.95, and 8.05–8.25 ka. Notably, an overall in‐phase relationship is observed between the hydroclimatic variations and change in solar activity, and the results of spectral analysis suggest the presence of the Eddy (~1,080 years), de Vries (~205 years), and Gleissberg (~88–102 years) cycles. This indicates a linkage between solar activity and hydroclimatic changes in ACA on centennial to multidecadal scales during the Holocene. We suggest that the influence of solar activity on hydroclimatic changes in ACA occurs via its effects on North Atlantic sea surface temperature, North Atlantic Oscillation, northern high‐latitude regional temperatures, and via direct heating. The relationship suggests that solar activity may play an important role in determining future hydroclimatic changes in ACA.
Effects of Local Dust Storms on the Upper Atmosphere of Mars: Observations and Simulations
Authors: Qin Jun Feng , Zou Hong , Ye Yu Guang , Yin Ze Fan , Wang Jing Song , Nielsen Erling 
Published: February 2019

AbstractThe effects of a local dust storm on the upper atmosphere of Mars are researched through the observations of the lower and upper Martian atmosphere in the MGS (Mars Global Surveyor) radio occultation experiments. The ionosphere profiles in the high‐latitude region of northern hemisphere are thought to be under the influence of a local dust storm occurring in the low‐latitude areas during Ls 135–150°, Mars Year (MY) 27. A method to estimate the Martian upper neutral densities via the heights of ionospheric main peak is presented. Through the method, the 130‐km atmospheric neutral densities (or CO2 densities) of the area during the dust storm were calculated. MCD V4.3 (Mars Climate Database, Version 4.3) is used to derive the normal (or dust‐storm‐free) neutral densities of the same region and period. By analyzing the differences between the calculated densities and MCD (V4.3) simulated ones, the influence of the local dust storm on the upper atmosphere densities can be quantitatively derived. Based on the variation of the upper atmosphere densities, the behavior of regional ionospheric main peak under the dust storm can be simulated by a photochemical equilibrium model. The simulated ionosphere parameters are compared with the MGS‐observed ones, and it is found that two profile data sets are consistent with one another, thus indicating that the method employed to estimate the upper neutral densities is accurate.
The association of urinary phosphorous-containing flame retardant metabolites and self-reported personal care and household product use among couples seeking fertility treatment
Authors: Ingle Mary E. , Mínguez-Alarcón Lidia , Carignan Courtney C. , Butt Craig M. , Stapleton Heather M. , Williams Paige L. , Ford Jennifer B. , Hauser Russ , Meeker John D. ,   for the EARTH Study Team
Published: February 2019

Abstract
Background
Phosphorous-containing flame-retardants (PFRs) are widely detected. They are used both as a flame retardant as well as plasticizer.

Methods
A subset of 230 women and 229 men were recruited from Massachusetts General Hospital fertility clinic between 2005 and 2015. At each visit, participants completed a questionnaire of personal care product (PCP) and household product (HP) use. Metabolites [bis(1,3-dichloro-2-propyl) phosphate, diphenyl phosphate (DPHP), isopropylphenyl phenyl phosphate (ip-PPP), tert-butylphenyl phenyl phosphate and bis(1-chloro-2-propyl) phosphate] were measured in urine (1–5 samples; n = 638 women, n = 335 men). Associations were assessed using generalized mixed models, adjusted for SG, age, BMI, smoking, education, and season.

Results
In women, moisturizer (60%), nail polish remover (77%), and nail polish (134%) use were associated (p < 0.05) with an increase in DPHP concentrations, while ip-PPP concentrations increased 21–27% with conditioner, cosmetics, deodorant, and hair product use. Mouthwash and vinyl glove use were associated with a respective 31% and 92% increase in DPHP among men.

Conclusions
Our exploratory analysis suggests PFRs may be used as a plasticizer in consumer products, and nail polish use contributes to internal DPHP exposure. Further research is needed to understand how PFRs are used in these products and how it relates to exposure.
PhaseStain: the digital staining of label-free quantitative phase microscopy images using deep learning
Authors: Rivenson Yair , Liu Tairan , Wei Zhensong , Zhang Yibo , de Haan Kevin , Ozcan Aydogan 
Published: February 2019

AbstractUsing a deep neural network, we demonstrate a digital staining technique, which we term PhaseStain, to transform the quantitative phase images (QPI) of label-free tissue sections into images that are equivalent to the brightfield microscopy images of the same samples that are histologically stained. Through pairs of image data (QPI and the corresponding brightfield images, acquired after staining), we train a generative adversarial network and demonstrate the effectiveness of this virtual-staining approach using sections of human skin, kidney, and liver tissue, matching the brightfield microscopy images of the same samples stained with Hematoxylin and Eosin, Jones’ stain, and Masson’s trichrome stain, respectively. This digital-staining framework may further strengthen various uses of label-free QPI techniques in pathology applications and biomedical research in general, by eliminating the need for histological staining, reducing sample preparation related costs and saving time. Our results provide a powerful example of some of the unique opportunities created by data-driven image transformations enabled by deep learning.
Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
Authors: Nazio Francesca , Bordi Matteo , Cianfanelli Valentina , Locatelli Franco , Cecconi Francesco 
Published: February 2019

AbstractAutophagy and mitophagy act in cancer as bimodal processes, whose differential functions strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to promote cancer progression by helping cancer cells survive stress or, instead, when mutated or abnormal, to induce carcinogenesis by influencing cell signaling or promoting intracellular toxicity. For this reason, the study of autophagy in cancer is the main focus of many researchers and several clinical trials are already ongoing to manipulate autophagy and by this way determine the outcome of disease therapy. Since the establishment of the cancer stem cell (CSC) theory and the discovery of CSCs in individual cancer types, autophagy and mitophagy have been proposed as key mechanisms in their homeostasis, dismissal or spread, even though we still miss a comprehensive view of how and by which regulatory molecules these two processes drive cell fate. In this review, we will dive into the deep water of autophagy, mitophagy, and CSCs and offer novel viewpoints on possible therapeutic strategies, based on the modulation of these degradative systems.
Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation
Authors: Parker Aimée , Vaux Laura , Patterson Angela M. , Modasia Amisha , Muraro Daniele , Fletcher Alexander G. , Byrne Helen M. , Maini Philip K. , Watson Alastair J. M. , Pin Carmen 
Published: February 2019

AbstractThe intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology over time, but the mechanisms driving early pathogenesis events are not clear. We studied the epithelial response to inflammation by combining mathematical models with in vivo experimental models resembling acute and chronic TNF-mediated injury. We found significant villus atrophy with increased epithelial cell death along the crypt-villus axis, most dramatically at the villus tips, in both acute and chronic inflammation. In the acute model, we observed overexpression of TNF receptor I in the villus tip rapidly after TNF injection and concurrent with elevated levels of intracellular TNF and rapid shedding at the tip. In the chronic model, sustained villus atrophy was accompanied by a reduction in absolute epithelial cell turnover. Mathematical modelling demonstrated that increased cell apoptosis on the villus body explains the reduction in epithelial cell turnover along the crypt-villus axis observed in chronic inflammation. Cell destruction in the villus was not accompanied by changes in proliferative cell number or division rate within the crypt. Epithelial morphology and immunological changes in the chronic setting suggest a repair response to cell damage although the villus length is not recovered. A better understanding of how this state is further destabilised and results in clinical pathology resembling IBD will help identify suitable pathways for therapeutic intervention.
Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer
Authors: Li Hengcun , Zhang Zheng , Chen Lei , Sun Xiujing , Zhao Yu , Guo Qingdong , Zhu Shengtao , Li Peng , Min Li , Zhang Shutian 
Published: February 2019

AbstractPrevious studies revealed that Asporin (ASPN) is a potential mediator in the development of various types of cancer as a secreted stroma protein, but the function of ASPN inside the cancer cells remains largely unknown. Here, we demonstrated a higher expression level of ASPN in colorectal cancer (CRC) than matched normal tissues, and 25% (2/8) CRC showed copy number variation (CNV) gain/amplification inASPNgene. Both higher ASPN expression levels andASPNCNV gain/amplification indicated a worse prognosis in CRC patients. ASPN can promote proliferation, migration, and invasion of CRC cells, and inhibit apoptosis by activating Akt/Erk and TGF-β/Smad2/3 signalings. Further investigations revealed that ASPN interacts with Smad2/3, facilitates its translocation into nucleus, and up-regulates the expression of Epithelial-mesenchymal transition (EMT) related genes. Rescue assays confirmed that TGF-β signaling is essential for the effects of ASPN on promoting CRC cell migration and invasion. In conclusion, ASPN promotes the migration and invasion of CRC cells via TGF-β/Smad2/3 pathway and could serve as a potential prognostic biomarker in CRC patients.
Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K–Akt pathway
Authors: Kucharava Krystsina , Sekulic-Jablanovic Marijana , Horvath Lukas , Bodmer Daniel , Petkovic Vesna 
Published: February 2019

AbstractGentamicin is a widely used antibiotic for the treatment of gram-negative bacterial infections; however, its use often results in significant and permanent hearing loss. Hearing loss resulting from hair cell (HC) degeneration affects millions of people worldwide, and one major cause is the loss of sensory HCs in the inner ear due to aminoglycoside exposure. Strategies to overcome the apparently irreversible loss of HCs in mammals are crucial for hearing protection. Here, we report that the somatostatin analog pasireotide protects mouse cochlear HCs from gentamicin damage using a well-established in vitro gentamicin-induced HC loss model and that the otoprotective effects of pasireotide are due to Akt up-regulation via the PI3K–Akt signal pathway activation. We demonstrate active caspase signal in organ of Corti (OC) explants exposed to gentamicin and show that pasireotide treatment activates survival genes, reduces caspase signal, and increases HC survival. The neuropeptide somatostatin and its selective analogs have provided neuroprotection by activating five somatostatin receptor (SSTR1–SSTR5) subtypes. Pasireotide has a high affinity for SSTR2 and SSTR5, and the addition of SSTR2- and SSTR5-specific antagonists leads to a loss of protection. The otoprotective effects of pasireotide were also observed in a gentamicin-injured animal model. In vivo studies have shown that 13 days of subcutaneous pasireotide application prevents gentamicin-induced HC death and permanent hearing loss in mice. Auditory brainstem response analysis confirmed the protective effect of pasireotide, and we found a significant threshold shift at all measured frequencies (4, 8, 16, 24, and 32 kHz). Together, these findings indicate that pasireotide is a novel otoprotective peptide acting via the PI3K–Akt pathway and may be of therapeutic value for HC protection from ototoxic insults.
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
Authors: Czechowicz Agnieszka , Palchaudhuri Rahul , Scheck Amelia , Hu Yu , Hoggatt Jonathan , Saez Borja , Pang Wendy W. , Mansour Michael K. , Tate Tiffany A. , Chan Yan Yi , Walck Emily , Wernig Gerlinde , Shizuru Judith A. , Winau Florian , Scadden David T. , Rossi Derrick J. 
Published: February 2019

AbstractHematopoietic stem cell transplantation (HSCT) is a curative therapy for blood and immune diseases with potential for many settings beyond current standard-of-care. Broad HSCT application is currently precluded largely due to morbidity and mortality associated with genotoxic irradiation or chemotherapy conditioning. Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor hematopoietic cell engraftment. Importantly, CD117-ADC selectively targets hematopoietic stem cells yet does not cause clinically significant side-effects. Blood counts and immune cell function are preserved following CD117-ADC treatment, with effective responses by recipients to both viral and fungal challenges. These results suggest that CD117-ADC-mediated HSCT pre-treatment could serve as a non-myeloablative conditioning strategy for the treatment of a wide range of non-malignant and malignant diseases, and might be especially suited to gene therapy and gene editing settings in which preservation of immunity is desired.
BLADE-ON-PETIOLE genes temporally and developmentally regulate the sheath to blade ratio of rice leaves
Authors: Toriba Taiyo , Tokunaga Hiroki , Shiga Toshihide , Nie Fanyu , Naramoto Satoshi , Honda Eriko , Tanaka Keisuke , Taji Teruaki , Itoh Jun-Ichi , Kyozuka Junko 
Published: February 2019

AbstractAxis formation is a fundamental issue in developmental biology. Axis formation and patterning in plant leaves is crucial for morphology and crop productivity. Here, we reveal the basis of proximal-distal patterning in rice leaves, which consist of a proximal sheath, a distal blade, and boundary organs formed between these two regions. Analysis of the three rice homologs of the Arabidopsis BLADE-ON-PETIOLE1 (BOP1) gene indicates that OsBOPs activate proximal sheath differentiation and suppress distal blade differentiation. Temporal expression changes of OsBOPs are responsible for the developmental changes in the sheath:blade ratio. We further identify that the change in the sheath:blade ratio during the juvenile phase is controlled by the miR156/SPL pathway, which modifies the level and pattern of expression of OsBOPs. OsBOPs are also essential for differentiation of the boundary organs. We propose that OsBOPs, the main regulators of proximal-distal patterning, control temporal changes in the sheath:blade ratio of rice leaves.
Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
Authors: Bittner Nora , Jockwitz Christiane , Mühleisen Thomas W. , Hoffstaedter Felix , Eickhoff Simon B. , Moebus Susanne , Bayen Ute J. , Cichon Sven , Zilles Karl , Amunts Katrin , Caspers Svenja 
Published: February 2019

AbstractLifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.
Author Correction: Layer-dependent quantum cooperation of electron and hole states in the anomalous semimetal WTe2
Authors: Das Pranab Kumar , Di Sante D. , Vobornik I. , Fujii J. , Okuda T. , Bruyer E. , Gyenis A. , Feldman B. E. , Tao J. , Ciancio R. , Rossi G. , Ali M. N. , Picozzi S. , Yazdani A. , Panaccione G. , Cava R. J. 
Published: February 2019

This Article contains an error in the spelling of the author A. Yazdani, which is incorrectly given as A. Yadzani. The error has not been fixed in the original PDF and HTML versions of the Article.
Network-based integrated analysis of omics data reveal novel players of TGF-β1-induced EMT in human peritoneal mesothelial cells
Authors: Han Soo Min , Ryu Hye-Myung , Suh Jinjoo , Lee Kong-Joo , Choi Soon-Youn , Choi Sangdun , Kim Yong-Lim , Huh Joo Young , Ha Hunjoo 
Published: February 2019

AbstractLong-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) of mesothelial cells is an important mechanism involved in peritoneal fibrosis, and TGF-β1 is considered central in this process. However, targeting currently known TGF-β1-associated pathways has not proven effective to date. Therefore, there are still gaps in understanding the mechanisms underlying TGF-β1-associated EMT and peritoneal fibrosis. We conducted network-based integrated analysis of transcriptomic and proteomic data to systemically characterize the molecular signature of TGF-β1-stimulated human peritoneal mesothelial cells (HPMCs). To increase the power of the data, multiple expression datasets of TGF-β1-stimulated human cells were employed, and extended based on a human functional gene network. Dense network sub-modules enriched with differentially expressed genes by TGF-β1 stimulation were prioritized and genes of interest were selected for functional analysis in HPMCs. Through integrated analysis, ECM constituents and oxidative stress-related genes were shown to be the top-ranked genes as expected. Among top-ranked sub-modules, TNFAIP6, ZC3H12A, and NNT were validated in HPMCs to be involved in regulation of E-cadherin, ZO-1, fibronectin, and αSMA expression. The present data shows the validity of network-based integrated analysis in discovery of novel players in TGF-β1-induced EMT in peritoneal mesothelial cells, which may serve as new prognostic markers and therapeutic targets for peritoneal dialysis patients.