bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ Ability in Varying English Sentences: A Gender Approach
Authors: Hanafi Nurachman , Jazadi Iwan , Nuriadi Nuriadi , Udin Udin , Djuhaeni Eni 
Published: July 2019

Studi ini menguji kemampuan mahasiswa dan mahasiswi S1 Bahasa Inggris untuk mengubah kalimat bahasa Inggris sesuai dengan perbedaan gender pada tingkat kalimat dasar: intransitif (one-place verb), transitif (two-place verb) dan ditransitif (three-place verb). Data korpus diperoleh dengan menggunakan tes pilihan ganda tertulis yang terdiri dari 30 item: 10 kalimat intransitif, 10 kalimat transitif dan 10 kalimat transitif. Penggunaan model uji ini dimaksudkan untuk memungkinkan mereka mengubah kalimat dasar bahasa Inggris secara praktis dan efisien dalam hal waktu. Setiap item memiliki 5 pilihan yang benar dan salah. Subyek diminta untuk memilih variasi yang dapat diterima sebanyak mungkin pada setiap item tes sesuai dengan aturan sintaksis bahasa Inggris yang berterima (gramatikal). Hasil penelitian menunjukkan bahwa rerata kemampuan para mahasiswa adalah 49,05% (sedang), sedangkan rerata kemampuan para mahasiswi adalah 34,75% (rendah). Adapun perbandingan kemampuan kedua kelompok mahasiswa dan mahasiswi terhadap tiga kalimat dasar sebagai berikut: (a) intransitif (18,28%: 11,94%), (b) transitif (14,21%: 11,33%) dan (c) ditransitif (16,56%: 11,48%). Kemampuan memvariasikan kalimat dasar bahasa Inggris mahasiswa lebih tinggi (14,8%) daripada kemampuan mahasiswi, walau rerata mereka masih tergolong moderat (50%). Ke depan, proses belajar-mengajar ketrampilan menulis Bahasa Inggris dari kalimat sederhana ke lebih kompleks perlu ditingkatkan dengan memperhatikan teori sintaksis agar dapat membantu mahasiswa dan mahasiswi S1 menulis kalimat bahasa Inggris yang benar (grammatically correct) dan secara budaya berterima (culturally acceptable). تبحث هذه الدراسة قدرة الطلاب على تغيير الجمل الإنجليزية وفقا للاختلافات بين الجنسين في مستويات الجملة الأساسية: إنترانسيتيف (الفعل في مكان واحد)، متعدية (الفعل من مكانين) و ديترانسيتيف (الفعل ثلاثة مكان). تم الحصول على مجموعة البيانات باستخدام اختبار اختيار متعدد مكتوب يتكون من 30 مادة، بما في ذلك 10 الجمل إنتيرزنيتيف، 10 متعدية و 10 جمل متعدية. وكان القصد من استخدام هذا النموذج اختبار لتمكين القدرة على تغيير جملها الإنجليزية بطريقة عملية وفعالة من حيث الوقت. كل بند لديه 5 الخيارات الصحيحة والخاطئة. وقد طلب من الموضوعات اختيار أكبر عدد ممكن من الاختلافات مقبولة على كل عنصر الاختبار وفقا للقواعد النحوية الإنجليزية النحوية. وأظهرت النتائج أن متوسط قدرة الطلاب الذكور هو 49.05٪ (معتدل)، في حين أن متوسط قدرة الطالبات هو 34.75٪ (منخفض). إن المقارنة بين كل من الذكور والإناث في الجمل الأساسية الثلاث هي: (أ) الأفعال ذات الموضع الواحد (18.28٪: 11.94٪)، (ب) الأفعال ذات الموضعين (14.21٪: 11.33٪) و (ج) ثلاثة الفعل -Blace (16.56٪: 11.48٪). القدرة على تغيير الجمل الإنجليزية للطلاب الذكور أعلى (14.8٪) من قدرة الطالبات، ومع ذلك لا يزال المتوسط مصنفا تحت المعتدل (50٪). في المستقبل، فمن الضروري تحسين مهارة التدريس في كتابة الجمل الإنجليزية الأساسية لطلاب المرحلة الجامعية بدءا من الفصل الدراسي الثاني.
Reconstruction of evolutionary trajectories of coffee chromosomes
Authors: Li Jing , Yuan Jiaqing , Zhao Yuhao , Meng Fanbo , Liu Chao , Zhang Zhikang , Guo He , Xie Yangqin , Hou Yue , Li Xinyu , Wang Xiyin 
Published: July 2019

Abstract
Background

Polyploidization is a widespread phenomenon in plants, especially in angiosperms. Because of the rearrangement of chromosomes and the loss of genes, the number of plant chromosomes will reduce. Studies have shown that core dicotyledons are derived from ancestors with seven proto-chromosomes, which triplicated in a core-eudicot-common hexaploidization. Therefore, dicotyledon with different chromosome numbers have evolved on the basis of 21 chromosomes. On this basis, we selected grape as the intermediate reference species to infer the karyotype evolutionary process of coffee.

Results

We found that all the chromosome fusion forms in grape were end-end joining, and 7 (70.0%) chromosome fusion forms in coffee were end-end joining. In the process of grape forming 19 chromosomes, there were three chromosome fusions and one chromosome fission. In the process of coffee 11 chromosomes formation, 10 chromosome fusions occurred. During the process, we inferred that satellite chromosomes formed by telomeres from the same or different chromosomes were produced; and the lost of them resulted in chromosome number reduction

Conclusions

Notably, we found that the major fusion mode of chromosomes in coffee is end-end joining, which is well explained by telomere-centric model, shared by grape and possibly by many other eudicots. This is contrastively different from the observation of monocot plants like grasses, in which nested chromosome fusions often occurred. The present work will help to understand the structural and functional innovations of plant chromosomes.
Patient satisfaction and objective outcome assessment following mid-urethral sling procedures in women with stress urinary incontinence: A prospective study
Authors: Ghanbari Zinat , Sany Seyedeh Belin Tavakoly , Hajhashemi Maryam , Radnia Nahid , Orooji Arezoo , Mohajer Taraneh 
Published: July 2019

Abstract
Background

Mid-urethral sling (MUS) operations are currently a recognized as the most popular and effective procedures for the surgical treatment of stress urinary incontinence (SUI) among women population. However, data reporting a long-term outcome is still equivocal, and thus, the data available are limited. This study aims to examine the efficacy of MUS operations after implantation for the treatment of women SUI during 3-years follow up.

Method

A prospective study was conducted in referral centers in the Tehran University of Medical Science, Emam Khomeini Hospital, Iran. 105 patients with urodynamically proven pure SUI or mix incontinence treated by MUS surgeries (TOT-TVT) were included. Patients with history of prior anti-incontinence surgery and abdominal radical pelvic surgery were excluded. Data regarding objective cure rates, subjective outcomes (Urogenital Distress Inventory Questionnaire–Short Form, Surgical Satisfaction Questionnaire) were collected during follow-up. We analyzed the preoperative parameters by univariate and multivariate

analysis was conducted to investigate outcomes.

Results

One hundred five women had MUS implantation. At 4-years follow-up, 101 women (95%) were available for the assessment. We find evidence of significant improvement in urinary symptoms, objective cure rates and patient satisfaction after operation. At 3-years follow up, 80 of 101 women (82.17%) indicated themselves cured. Similarly, at 3-years evaluation, 83 of 101 women (82.17%) were satisfied or very satisfied, not showing visible urine leakage; and a state that did not need interval surgery. The multivariate analysis of the preoperative parameters revealed that age, VD, absences of urgency symptoms were the parameters related independently to the surgical success and patient’s satisfaction and Qmax was well associated with postoperative voiding dysfunction (PVD).

Conclusion

The 4-years findings of this study suggest that MUS surgeries are an effective procedures for the treatment of SUI.
Does Case-based blended-learning expedite the transfer of declarative knowledge to procedural knowledge in practice?
Authors: Turk Bela Rui , Ertl Sebastian , Wong Guoruey , Wadowski Patricia P , Loeffler-Stastka Henriette 
Published: July 2019

Abstract
Background

Case-Based Learning (CBL) has seen widespread implementation in undergraduate education since the early 1920s. Ample data has shown CBL to be an enjoyable and motivational didactic tool, and effective in assisting the expansion of declarative and procedural knowledge in academia. Although a plethora of studies apply multiple choice questions (MCQs) in their investigation, few studies measure CBL or case-based blended learning (CBBL)-mediated changes in students’ procedural knowledge in practice or employ comparison or control groups in isolating causal relationships.

Methods

Utilizing the flexibilities of an e-learning platform, a CBBL framework consisting of a) anonymized patient cases, b) case-related textbook material and online e-CBL modules, and c) simulated patient (SP) contact seminars, was developed and implemented in multiple medical fields for undergraduate medical education. Additionally, other fields saw a solo implementation of e-CBL in the same format. E- cases were constructed according to the criteria of Bloom’s taxonomy.

In this study, Objective Structured Clinical Examination (OSCE) results from (n=619) medical students in 2013 before CBBL implementation, and after CBBL implementation in 2015 (n=624) and 2016 (n=643) were analyzed.

Results

A significant improvement (adjusted p=.002) of the mean OSCE score by 1.02 points was seen between 2013 and 2015 (min=0, max=25).

Conclusion

E-Case-Based Learning is an effective tool in increasing student satisfaction, improving performance outcomes and may provide a sustainable learning platform for many fields of medicine in future.
Meningitis gone viral: Description of the German Echo Wave 2013
Authors: Graf Jonas , Hartmann Christian , Lehmann Helmar C , Otto Carolin , Adams Ortwin , Karenfort Michael , Schneider Christian , Ruprecht Klemens , Bosse Hans Martin , Diedrich Sabine , Böttcher Sindy , Schnitzler Alfons , Hartung Hans-Peter , Aktas Orhan , Albrecht Philipp 
Published: July 2019

Abstract
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges.
OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013.
RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 2.1% of all EV-positive cases which were voluntarily reported within the National Enterovirussurveillance (based on investigation of patients with suspected aseptic meningitis/encephalitis and acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were echovirus-positive (18 pediatric and 20 adult cases, median age 18.5 years). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and one EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home.
CONCLUSION: Voluntary disease-specific surveillance, such as provided by the National Enterovirussurveillance in our study may be a valuable tool for epidemiological research.
Vaikų elgesio kultūros ugdymo(si) būdai ir metodai Radviliškio miesto „X“ ikimokyklinėje ugdymo įstaigoje (atvejo analizė)
Authors: Smilgienė Jurgita , Jonaitienė Dalė 
Published: July 2019

Nesvarbu, kokio amžiaus vaikas bebūtų, ugdant tinkamą elgesio kultūrą, svarbiausi yra suaugusieji, kurie savo elgesiu ir požiūriu į juos daro didžiausią įtaką. Ne tik šeima, bet ir ikimokyklinio ugdymo įstaiga tampa atsakinga už vaikų elgesio kultūros ugdymą, švietimą bei skatinimą elgtis mandagiai, pagarbiai, sąžiningai, draugiškai ir t. t. Kultūringo elgesio įgūdžių ir įpročių formavimas, įvairiapusis elgesio kultūros ugdymo būdų taikymas, laisvas kūrybinis darbas sudaro sąlygas ugdytiniams save pažinti, kurti, išreikšti. Darbo procese jie ugdo(si) bendravimo ir bendradarbiavimo įgūdžius, atsakomybę už savo ir grupės darbo rezultatus. Šiame kontekste formuluotas probleminis tyrimo klausimas – kokiais būdais ugdoma vaikų elgesio kultūra ikimokyklinėje ugdymo įstaigoje?Tyrimas buvo atliekamas „X“ miesto ikimokyklinėje ugdymo įstaigoje. Vykdant pedagogų apklausą raštu atskleistos trylikos pedagogų patirtys apie jų taikomus būdus vaikų elgesio kultūrai ugdyti. Kokybinio tyrimo duomenys apdoroti turinio analizės būdu.Atliktas pedagogų patirties tyrimas atskleidė, kad ikimokyklinio ugdymo įstaigoje dirbantys pedagogai elgesio kultūros ugdymą laiko prioritetine sritimi. Veikloje vyrauja tradiciniai, vaiko poreikius atitinkantys elgesio kultūros ugdymo metodai, t. y. žaidimai, pokalbiai, pavyzdžio metodas, rečiau minimos netradicinės ugdymo formos. Kaip labiausiai pasiteisinusius vaikų elgesio kultūros ugdymui(si) būdus, metodus pedagogės vardijo tokius, kaip drausminimas, skatinimas, taisyklių laikymasis, ekskursijų ir išvykų organizavimas, grožinės literatūros skaitymas ir analizė.
PENGGUNAAN LKS BERBASIS KARAKTER BERPIKIR KRITIS TERHADAP HASIL BELAJAR FISIKA SISWA KELAS X MIPA SMA
Authors: Karisma Mariska 
Published: July 2019

Penelitian ini dilatarbelakangi oleh hasil pembelajaran fisika siswa dengan menggunakan lembar kerja siswa konvensional yang masih rendah. Populasi siswa adalah seluruh siswa kelas X matematika dan fisika SMA Negeri 9 Padang yang terdiri lima kelas. Teknik pengambilan sampel adalah cluster random sampling memilih kelas X matematika dan fisika 5 sebagai eksperimen, dan kelas X matematika dan fisika 4 sebagai kelas kontrol. Instrumen yang digunakan adalah uji prestasi fisika dalam bentuk lembar penilaian esai dan keterampilan. Berdasarkan lembar penilaian ketrampilan yang dikenal dengan predikat kelas eksperimen 96,90 nilai A, dan kelas kontrol 73,20 bernilai B . Sedangkan berdasarkan uji prestasi fisika diketahui kelas eksperimen berkonotasi 87,58 dan predikatB, kelas kontrol 73,20 berkonversi 2,93 predikat C. Hasil analisis data diketahui bahwa kedua sampel tersebut biasanya distribusinya dan tidak memiliki ho mogeny, pada tingkat α = 0,05. Uji hipotesis diperoleh t’ = 2,52 dan t = 1,20 berarti t’ > t hipotesis diterima. Kata kunci: Hasil pembelajaran fisika, lembar kerja siswa berbasis pemikiran kritis
PENGARUH MODEL PEMBELAJARAN LANGSUNG DISERTAI QUIZ TEAM PADA PEMAHAMAN KONSEP FISIKA KELAS VIII SMP NEGERI 22 PADANG
Authors: Puspa Melia 
Published: July 2019

Penelitian ini dilatarbelakangi oleh hasil belajar fisika siswa yang masih rendah. Hal itu disebabkan beberapa siswa dalam proses belajar yang kurang aktif. Oleh karena itu, proses pembelajaran diaplikasikan, dengan menggunakan model pembelajaran langsung oleh tim kuis. Jenis penelitian adalah percobaan kuasi, dengan desain kelompok kontrol posttest saja. Penelitian ini menggunakan teknik cluster random sampling. Menurut hasil uji hipotesis dengan uji Mann Withney diperoleh Z_hitung = 2,43> Z_tabel = 1,76, maka H_0 ditolak. Selain data yang diperoleh dari hasil uji akhir ada juga data hasil belajar dari domain afektif. Persentase rata-rata hasil belajar afektif siswa kelas eksperimen adalah 72,38% sedangkan kelas kontrol 60,10%. Berdasarkan hasil analisis uji akhir dan data domain afektif yang telah diperoleh dapat disimpulkan bahwa ditemukan hasil pembelajaran fisika siswa kelas VIII SMPN 22 Padang yang menerapkan model pembelajaran langsung disertai Tim Kuis.Kata kunci Pembelajaran Langsung, Tim kuiz, Hasil pembelajaran siswa
PENGARUH PENGGUNAAN TEKNIK PROBING PROMPTING DALAM PEMBELAJARAN DISCOVERY LEARNING TERHADAP HASIL BELAJAR SISWA
Authors: Maysyarah Rahayu 
Published: July 2019

Penelitian ini berdasarkan pada siswa yang tidak terbiasa dengan model discovery learning . Fenomena ini menyebabkan hasil belajar siswa dari ilmu pengetahuan alam masih rendah. Penelitian ini bertujuan untuk mengetahui penggunaan teknik simulasi probing dalam model discovery learning terhadap hasil belajar sains siswa kelas VII SMPN 1 Sutera. Populasi penelitian ini adalah seluruh siswa kelas VII SMP N 1 Sutera yang terdiri dari delapan kelas. Metode pengambilan sampel adalah cluster random sampling yang dipilih pada kelas VII.5 sebagai percobaan, dan kelas VII.2 sebagai kelas kontrol. Instrumen yang digunakan adalah uji prestasi sains dalam bentuk esai. Berdasarkan uji prestasi sains diketahui nilai rata-rata kelas eksperimen 62 dan kelas kontrol 50. Hasil analisis data diketahui kedua sampel tersebut tidak normal distribusinya namun homogen, pada taraf nyata α = 0,05. Uji hipotesis diperoleh analisis uji mann whitney dengan Zhitung = 2,08 dan Ztable = 0,98 berarti Zhitung> Ztable sehingga hypothesis diterima. Kata kunci: Pembelajaran Discovery, Hasil Belajar Ilmu Pengetahuan Alam Siswa, Probing Prompting
PENGARUH PENGGUNAAN METODE PROBLEM SOLVING LEARNING TERHADAP HASIL BELAJAR FISIKA SISWA KELAS XII IPA MAN 1 PESISIR SELATAN
Authors: Meki Septika Ulan 
Published: July 2019

Penelitian ini didasarkan pada kurangnya interaksi siswa dalam proses belajar mengajar yang membuat siswa tidak memahami konsep fisik. Untuk menyelesaikan masalah di atas, solusinya adalah menerapkan metode pembelajaran pemecahan masalah. Instrumen berupa uji domain kognitif dalam tes akhir, lembar observasi siswa sebagai uji domain afektif. Belajar otcome dalam domain kognitif yang diperoleh, nilai rata-rata kelas eksperimen adalah 55,14 dan kelas kontral 46,24. Hasil aktivitas domain afektif menunjukkan bahwa nilai rata-rata kelas eksperimen lebih tinggi daripada kelas kontrol, yaitu 82,65 untuk kelas eksperimen dan 71,91 untuk kelas kontrol. Singkatnya, ada pengaruh menggunakan metode pembelajaran problem solving terhadap hasil belajar fisik XII IPA MAN 1 Pesisir Selatan.Kata Kunci: Pembelajaran Fisika, Problem Solving Learning, Hasil Belajar Fisika.
PENGARUH PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE GROUP INVESTIGATION TERHADAP HASIL BELAJAR FISIKA PESERTA DIDIK KELAS XI MIPA
Authors: Karmilawati Afni , Rahmi Aidhia 
Published: July 2019

The background of this research not all students like physics learning. This is caused by students' lack of understanding of physics learning material. The students' incomprehension can be seen when the learning process takes place, some students are embarrassed to ask even though basically the students do not understand the material presented by the teacher in front of the class. This type of research is Quasi Experiment with research design in the form of Design Group Control. Data on physics learning results are seen in two domains, namely the cognitive and affective domains. In the cognitive domain, the average experimental class has an average of 67.37 while the class has an average of 60.76. Learning outcomes in the affective domain obtained from the assessment of student activity sheets had an average of 79 in the experimental class and 74 in the control class. Based on the results of the analysis of hypothesis testing with the F test, it was found that t count = 1.64, and t table = 2.00, where if –t table < t count < t table then the hypothesis is rejected. So it can be concluded that the use of cooperative learning model type Group Investigation does not affect the learning outcomes of physics students of class XI MIPA SMAN 1 Enam Lingkung.
THE MOLDAVIAN COMPOSER V. ROTARU AND HIS CHAMBER-INSTRUMENTAL WORK.
Authors: DJALİLOVA Natalia 
Published: July 2019

This article analyzes the piano Trio INO-3 V. Rotaru, its significance
in the author's work, the basic style, the harmonic, rhythmic and inerprtative
aspects. The connection with neo-folklore direction in music and traditional
genres in Moldovan folk music is revealed, the synthesis of traditional folklore
with modern composition techniques.This article assumes to define first of all value of the considered Trio
INO-3 in the context of all area of chamber-instrumental music of V. Rotaru, as
the last composition of the composer in this genre sphere. The article also
focuses on the neo-folklore features of the composer's style and their
harmonious combination with the classical traditions typical of the trio of
Russian and Western European composers. As for the classical traditions, the
Trio is a three-part cycle with a characteristic tempo dramaturgy:I. ModeratoII. Lento
e molto lamentoIII. Allegro
moderatoSince this Trio is the last in the cycle and was
written shortly before the composer's death, the author's appeal to the genre
of mourning Saraband in the middle part is of interest. As for the neo-folk
style elements, they define the whole thematic, rhythmic and Lado - harmonic
material of the composition. The article focuses on the Lado - harmonic
features of all parts of the Trio, which are characteristic intonation formulas
of Moldovan folklore: motives with II increased and decreased levels, motives
with IV increased level, VI increased level, enriched with melismatics. From
the point of view of rhythm, the composer relies on the rhythmic formulas of fast
Moldovan dances, with variable meters and changing accents. The ensemble
texture goes back to the classical traditions, which consist in frequent
variation of thematism transmitted from one member of the ensemble to another,
as well as in rich polyphonic techniques such as imitation, Canon and
contrasting polyphony. In General, the trio INO3 is a concert composition with
vivid figurative contrasts, which is worthy of being in demand in pedagogical
and concert practice in our country and abroad.
PENGEMBANGAN E-LKPD BERPENDEKATAN SAINTIFIK LARUTAN ELEKTROLIT DAN NON ELEKTROLIT
Authors: Apriyanto Candra , Yusnelti Yusnelti , Asrial Asrial 
Published: July 2019

Telah dilakukan penelitian tentang pengembangan e-LKPD berpendekatan saintifik pada materi larutan elektrolit dan non elektrolit kimia SMA. Penelitian ini meliputi pengembangan e-LKPD dan respon siswa serta penilaian guru terhadap e-LKPD tersebut. Pengembangan e-LKPD menggunakan desain 4-D yang meliputi 4 tahap pengembangan yaitu Define, Design, Development, dan Desseminate. Instrumen yang digunakan untuk memvalidasi berupa validasi materi dan validasi media serta angket respon siswa dan angket penilaian guru. Berdasarkan hasil respon siswa pada uji coba kelompok kecil diperoleh persentasi skor sebesar 81,7% dan melihat data tabel kriteria penilaian kualifikasi produk, maka produk yang dikembangkan oleh pengembang dapat dikategorikan sangat baik. Sedangkan pada uji coba kelompok besar diperoleh persentasi skor sebesar 82,3% yang mengidentifikasikan produk yang dikembangkan termasuk kategori sangat baik.
Kata Kunci : LKPD Elektronik, Pendekatan saintifik, Larutan elektrolit dan non elektrolit
Pasif Tümör Hedefli İnorganik İlaç Nanotaşıyıcıların Akciğer Sağlıklı ve Kanser Hücreleri Üzerindeki Uzun Dönemli Etkisi
Authors: DAĞLIOĞLU Cenk , KACI Fatma Necmiye 
Published: July 2019

İlaç nanotaşıyıcıları, kontrollü ve
sürekli ilaç salım özellikleri ile kanser tedavisinde büyük bir potansiyele
sahiptir. Bu nanotaşıyıcılar pasif veya aktif hedefli olarak ilaç taşınımı
sağlayabilmektedir, ancak aktif hedefli muadillerine göre, pasif hedefli
nanotaşıyıcılar tümörlü dokularda daha yavaş ve düşük düzeyde ilaç birikimi
sağladığından kanserli hücrelerin yanında sağlıklı hücrelerde uzun süre bu
nanotaşıyıcılara maruz kalmaktadır. Bu nedenle, bu çalışmada, pasif hedefli
ilaç nanotaşıyıcıların insan akciğer epitel BEAS-2B hücreleri ve insan akciğer
kanser A549 hücreleri üzerindeki uzun dönem etkileri araştırıldı. Bunun için,
görüntüleme ve tedavi edici özellikleri bir arada barından Fe3O4@SiO2(FITC)-DOX
formülasyonuna sahip ilaç nanotaşıyıcıları kullanıldı ve hücresel birikim,
sitotoksisite ve apoptoz üzerindeki etkileri araştırıldı. Hücresel alım ve
sitotoksisite deneyleri, pasif hedefli nanotaşıyıcıların kanser hücresi canlılığının
etkin bir şekilde azalttığını gösterirken, 24 saatlik inkübasyon sürecinde
sağlıklı hücreler üzerinde kayda değer bir etki görülmedi. Ancak 96 saatlik
uzun inkübasyon sürecinde, sağlıklı BEAS-2B hücreleri makul seviyelerde
nanotaşıyıcı alımı gerçekleştirirken, A549 kanser hücrelerine kıyasla düşük
düzeylerde ilaç-aracılı sitotoksisite sergiledi. Ayrıca, nanotaşıyıcılar A549
hücrelerindeki apoptoz seviyelerini önemli ölçüde artırırken, BEAS-2B
hücrelerinde 96 saat sonunda dahi apoptotik etki göstermedi. Bu sonuçlar, pasif
hedefli inorganik ilaç nanotaşıyıcıların, sağlıklı hücreleri ihmal edilebilir
düzeyde etkileyerek, antikanser
ilaçların kemoterapötik etkilerini artırmada umut verici olduğunu göstermektedir.