bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of plasma LP(a), Hcy and D-D levels with the subtype of ischemic cerebrovascular disease
Authors: Tang Yong , Geng Deqin 
Published: March 2019

Abstract
The relevance of LP(a), Hcy, and D-D in ischemic cerebrovascular disease remains undefined. This study aimed to assess the associations of plasma LP(a), Hcy and D-D levels with the subtype of ischemic cerebrovascular disease.
Patients with ischemic cerebrovascular disease admitted to the Taixing People's Hospital were retrospectively enrolled from November 2017 to July 2018. Immunoturbidimetry was used to assess 119 LAA, 107 SAO, and 112 TIA patients for plasma LP(a), Hcy, and D-D levels.
Plasma LP(a), Hcy, and D-D levels in the large artery atherosclerosis (LAA) group were significantly lower than those of the transient ischemic attack (TIA) group (all P < .05). LP(a), Hcy, and D-D levels were significantly reduced in the SAO group compared with the TIA group (both P < .05). The LAA and SAO groups showed comparable values for all the above parameters (P > .05).
LP(a), Hcy, and D-D levels differ according to the subtype of ischemic cerebrovascular disease.
The reciprocal influences of prognosis between two types of surgical interventions and early breast cancer patients with diverse luminal subtypes
Authors: He Lin , Zhao Shengnan , Liu Min , Su Zhumin , Ren Yuanzhong , Song Yuhua 
Published: March 2019

Abstract

Background:
To investigate and compare the effects of breast-conserving therapy (BCT) and mastectomy on the disease recurrence and long-term survival in early-stage luminal breast cancer and the difference in prognosis across diverse luminal subtypes receiving single surgical modality.

Methods:
The databases of PubMed and Embase were retrieved to select eligible trials that were published from inception to 13 November 2018. The clinical trials that offered the details about recurrent disease and/or survival in luminal tumors underwent BCT or mastectomy met the inclusion criteria (n=24). With the random- or fixed-effect model basing on heterogeneity Chi2 test with its significant level of P < .1, pooled odds ratio (OR) with its 95% CI, and P value were identified for endpoints.

Results:
The analyzed data were constituted of 25 qualified trials with 13,032 unique women suffered from luminal cancers. The fixed-effect models were utilized. On the LRR regarding BCT versus mastectomy, the pooled data indicated no significant difference in luminal carcinomas (OR, 0.84; 95%CI, 0.43–1.64; P = .61; n = 867). In BCT cohort, the pooled data showed that there were some significant benefits favoring luminal A over luminal B in LR (OR, 0.61; 95%CI, 0.46–0.81; P = .0007; n = 5406), DM (OR, 0.53; 95%CI, 0.41–0.69; P < .00001; n = 4662), DFS (OR, 0.59; 95%CI, 0.36–0.96; P = .03; n = 776) and OS (OR, 0.65; 95%CI, 0.42–0.99; P = .05; n = 1149), but not in LRR (OR, 0.74; 95%CI, 0.48–1.13; P = .16; n = 3732), coupled with luminal A/B over luminal-HER2 in LRR (OR, 0.43; 95%CI, 0.25–0.76; P = .004; n = 890), DM (OR, 0.56; 95%CI, 0.35–0.90; P = .02; n = 1396), DFS (OR, 0.47; 95%CI, 0.27–0.83; P = .009; n = 532); in mastectomy cohort, there were apparent advantages of LRR (OR, 0.58; 95%CI, 0.36–0.92; P = .02; n = 1768), LR (OR,0.56; 95%CI, 0.38–0.83; P = .004; n = 1209), DM (OR, 0.58; 95%CI, 0.40–0.84; P = .004; n = 652) and OS (OR, 0.62; 95%CI, 0.43–0.89; P = .009; n = 652) in luminal A vs luminal B.

Conclusion:
For early luminal breast cancer, the equality of LRR was achieved in BCT and mastectomy. In comparison, luminal A cancers benefit the most improved tumor re-appearence and survival in luminal diseases regardless of the option of surgical modality, whereas luminal-HER2 is affected by the worst clinical outcomes in them who follows BCT.
The effects of methotrexate and uterine arterial embolization in patients with cesarean scar pregnancy
Authors: Xiao Zhuoni , Cheng Dan , Chen Jiao , Yang Jing , Xu Wangming , Xie Qingzhen 
Published: March 2019

Abstract
In this study, we explored the optimal treatment for cesarean scar pregnancy (CSP). One hundred three women diagnosed with CSP received 1 of the 3 treatments: local or systemic methotrexate (MTX) injection and surgery (MTX + Surg), uterine arterial embolization (UAE) and surgery (UAE + Surg) or surgery only (Surg only). We compared their therapeutic effects and their follow-up results. There was no significant difference between the groups in the baseline of clinical characteristic except for the initial β human chorionic gonadotropin levels, which was highest in the MTX + Surg group (median, [interquartile range]), (120,004 [16,720–181,727] mIU/mL), compared to the UAE + Surg group (38,219 [23,194–100,029] mIU/mL) and Surg only group (22,557 [9113–49,573] mIU/mL). There was no significant difference between groups in the sonographic characteristic of patients. The intraoperative hemorrhage was highest in the Surg-only group (7/42, 16.67%), compared to the MTX + Surg group (4/26, 15.38%) and the UAE + Surg group (0/35, 0%). The incidence of intrauterine adhesions was highest in the UAE + Surg group (20%), compared to the MTX + Surg group (0%) and the Surg only group (0%). The incidence of embryo residue was highest in Surg-only group (21.43%), compared to the MTX + Surg group (0%) and the UAE + Surg group (2.86%). To conclude, MTX injection plus surgery might be the best treatment for CSP patients.
Gestational diabetes mellitus increases the baseline level of procalcitonin in maternal blood but not in umbilical cord blood in late pregnancy
Authors: Ma Yan , Ye Wenfeng , Tang Yanhong 
Published: March 2019

Abstract
To study the effects of gestational diabetes mellitus (GDM) on the level of procalcitonin (PCT) in maternal blood and umbilical cord blood in late-pregnant women.
We retrospectively analyzed 37 pregnant women in late pregnancy who had GDM and compared with those of 97 age-matched normal glucose-tolerant (NGT) pregnant women. The PCT level was converted to a value with normal distribution (LG-PCT) by taking the logarithm of each value to the base 10 (log10).
The body mass index (BMI) before delivery, family history of diabetes mellitus (DM), and postpartum blood loss within 24 hours were markedly higher in GDM group than in NGT group, while the gestational age was smaller in GDM group than in NGT group. The maternal blood LG-PCT was significantly higher in GDM group than in NGT group, while the umbilical cord blood LG-PCT was not significantly different between the 2 groups. Multivariate analysis showed that family history of DM, gestational age, and maternal blood LG-PCT were independent risk factors of GDM after adjusting for BMI and postpartum blood loss within 24 hours.
GDM increases the baseline level of maternal blood PCT but has little effect on umbilical cord blood PCT.
Prediction of surgical management for operated adhesive postoperative small bowel obstruction in a pediatric population
Authors: Deng Yuhua , Wang Yongming , Guo Chunbao 
Published: March 2019

Abstract
Abdominal surgery might contribute to postoperative intraperitoneal adhesions, with a high rate of recurrence. In the present study, we aimed to analyze potential factors for the surgical intervention of operated adhesive postoperative small bowel obstruction (SBO) in pediatric patients and compare the outcomes of patients managed by conservative treatment or surgical operation for an episode of SBO.
From January 2007 to January 2017, the records of 712 patients admitted with SBO to Children's Hospital, Chongqing Medical University, were reviewed retrospectively. The patients were divided according to surgical intervention or conservative management. Potential predictors for surgical intervention were investigated, including the initial operation data and the current clinical variables. A Cox regression model was used to determine the independent risk factors of surgical intervention. A systematic follow-up for recurrence was performed based on surgical intervention or conservative management.
Among the 712 patients admitted with SBO, 266 patients were managed surgically and 446 patients were managed conservatively. In the multivariate analysis, the predictors for the surgical intervention included initial surgical features, such as elevated markers of inflammation (WBC, CRP), incision location (HR, 2.31; 95CI, 1.29–5.26; P = .031), and emergency procedure (HR, 1.46; 95%CI, 1.13–3.42; P = .014), and current variables, such as crampy pain (HR, 4.66; 95%CI, 1.69–9.48; P < .001), ascites (HR, 5.43; 95%CI, 1.84–13.76; P < .001) and complete small bowel obstruction (HR, 3.21; 95%CI, 1.45–8.74; P < .001). The median follow-up time (interquartile range) was 3.6 years (range, 1 month-8 years) for the entire study population. Twenty-one patients (9.2%) who had undergone surgical intervention were rehospitalized for a new SBO episode, as were 53 patients (14.9%) who had been managed conservatively (P = .028; OR, 1.72, 95% CI, 1.00–2.95).
Operated adhesive postoperative SBO with the following characteristics should heighten vigilance for surgical intervention: an initial emergency procedure with midline incisions and the current strangulation status. New hospitalizations were lower after surgical management than conservative treatment.
Prevalence of Obsessive-Compulsive Disorder in Patients With Schizophrenia and Outcome on Positive and Negative Symptoms, Cognition, and Quality of Life
Authors: Wehbé Joelle , Haddad Chadia , Obeid Sahar , Hallit Souheil , Haddad Georges 
Published: March 2019

Abstract
The objectives were to examine the prevalence of obsessive-compulsive disorder (OCD) in hospitalized patients with schizophrenia and to compare the clinical, cognitive, and functional characteristics of schizophrenia patients with and without OCD. This cross-sectional study, performed between May and August 2018, enrolled 308 patients (200 men and 108 women). The prevalence of OCD in patients with schizophrenia was 3.2%. An increase in patients having a mild β was significantly associated with higher social relationship score (β = 1.68) and the Memory Functioning Scale–Informant (MFS-I) version (β = 5.67). OCD did not affect the positive and negative symptoms of these patients. The prevalence of OCD in these patients was low (3.2%). Schizophrenia patients with and without OCD have comparable clinical profiles with few exceptions. The existence of OCD may affect the social relationship quality of life and the MFS-I version.
Depressive Symptom Severity in Individuals With Epilepsy and Recent Health Complications
Authors: Kumar Neha , Lhatoo Rigzin , Liu Hongyan , Colon-Zimmermann Kari , Tatsuoka Curtis , Chen Peijun , Kahriman Mustafa , Sajatovic Martha 
Published: March 2019

Abstract
Identifying relationships between depression severity and clinical factors may help with appropriate recognition and management of neuropsychiatric conditions in persons with epilepsy (PWE). Demographic characteristics, epilepsy variables, and medical and psychiatric comorbidities were examined from a baseline randomized controlled trial sample of 120 PWE. Among demographic characteristics, only inability to work was significantly associated with depression severity (p = 0.05). Higher 30-day seizure frequency (p < 0.01) and lower quality of life (p < 0.0001) were associated with greater depression severity. Comorbid bipolar disorder (p = 0.02), panic disorder (p < 0.01), and obsessive-compulsive disorder (p < 0.01) were correlated with worse depression severity. The literature supports our findings of correlations between worse depression, seizure frequency, and lower quality of life. Less well studied is our finding of greater depression severity and selected psychiatric comorbidities in PWE.
Prevalence of Religious and Spiritual Experiences and the Perceived Influence Thereof in Patients With Bipolar Disorder in a Dutch Specialist Outpatient Center
Authors: Ouwehand Eva , Braam Arjan W. , Renes Janwillem , Muthert Hanneke J.K. , Stolp Hanne A. , Garritsen Heike H. , Zock Hetty T.H. 
Published: March 2019

Abstract
The aim of the current cross-sectional study was to estimate the prevalence of religious and spiritual (R/S) experiences and their perceived lasting influence in outpatients with bipolar disorder (BD; n = 196). A questionnaire with a range of R/S was constructed, building on the results of an earlier qualitative study. Experiences of horizontal transcendence (not necessarily referring to the divine) such as the experience of “intense happiness, love, peace, beauty, freedom” (77%) or “meaningful synchronicity” (66%) were the most prevalent. The experience of “divine presence” (vertical transcendence, referring to the divine) had a prevalence of 44%. Perceived lasting influence of the experiences was 20% to 67% of the total frequency, depending on the type. Most positive R/S experiences were significantly more related to BD I and mania, and on average, persons with BD I had more R/S experiences (mean = 4.5, SD = 2.6) than those with BD II (mean = 2.8, SD = 2.4, p = 0.000). Patient-reported R/S experiences in BD can have both R/S and pathological features.
Predictors of Consent to Treatment and Premature Termination of Treatment in a Sample of Veterans With Military-Related PTSD
Authors: Levi Ofir , Lazarov Amit , Bar-Haim Yair , Lubin Gadi , Wald Ilan 
Published: March 2019

Abstract
This study examined different variables as predictors of treatment entry and treatment dropout among veterans with military-related posttraumatic stress disorder (PTSD). First, we examined predictors of treatment entry versus refusal of treatment. Among the veterans who started therapy, we examined predictors of treatment completion. Symptom severity of PTSD, depression, and anxiety at baseline were measured. Daily functioning at baseline was also measured. Results indicate that the younger the veterans were, the more likely they were to refuse treatment. Dropout from treatment was also predicted by younger age at referral, as well as by past treatment, higher number of years of education, and higher depression levels at baseline. Two conclusions can be drawn from the results. First, it may be beneficial to increase awareness of treatment options for PTSD among younger veterans as this may increase treatment consent rates. Second, to reduce treatment dropout in veteran patients with PTSD, therapists should take into consideration both past treatment and baseline depression levels as risk factors for dropout.
Cultural and Generational Considerations in RN Retention
Authors: Dols Jean Dowling , Chargualaf Katie A. , Martinez Kathryn S. 
Published: March 2019

OBJECTIVE
The aim of this study was to identify evolving cultural and generational factors influencing nurse retention.

BACKGROUND
Multigenerational/culturally diverse workforces challenge the nurse leader's understanding of nurse satisfaction.

METHODS
A survey was designed to identify the RN's career intentions, desired leadership traits, and practice environment appraisal.

RESULTS
While generally satisfied with their current position, generational differences in the average number of years nurses intend to stay at their current employer exist with Millennials anticipating staying 3.03 years; Generation X, 5.83 years; and Boomers, 8.25 years. Perceived inability to meet patient needs, which varied by generation, was significantly related to nurse satisfaction (P < .01). Factors identified by the nurses that may improve retention, regardless of generation, were pay, staffing, and nursing leadership support. Preferred leader traits varied by generation and ethnicity. Hispanic nurses value hardworking, honest leaders, whereas non-Hispanic nurses value dependability.

CONCLUSION
Nurse leaders must individualize efforts to retain an ethnically diverse and multigenerational nursing workforce.
Clinical Training Innovation for Prelicensure Graduate Nursing Students to Expand Roles in Primary Care
Authors: Hooper-Arana Erica D. , Li Judy N. , Borges Wanda J. , Bodenheimer Thomas 
Published: March 2019

Background
With the aging population, the prevalence of chronic disease is increasing, requiring a team-based approach to care with registered nurses (RNs) playing a vital role.

Problem
Nursing education generally prioritizes acute care rather than ambulatory care; however, nursing students should also be prepared to adequately respond to the population needs for longitudinal chronic care management.

Approach
To address the need for RNs to assume a role in chronic care management, a School of Nursing and Health Professions piloted a clinical option in which second-degree master of science in nursing students are prepared to function as health coaches on primary care teams at a local community health center.

Conclusions
Reshifting the focus of nursing education to integrate primary care nursing, it is important to embed nursing students into primary care practices where they can learn about the longitudinal care of patients with chronic conditions.
Sick Students
Authors: Critz Catharine , Feagai Hobie Etta , Akeo April , Tanaka Mieko , Shin Juh Hyun , Erickson Michael , Ikeda Mari , Moriya Haruyo , Ozaki Kyoko 
Published: March 2019

Background
Presenteeism, the act of going to work while sick, is associated with increases in medication errors, patient falls, diminished quality of care, and higher costs. To date, presenteeism has not been described among nursing students.

Purpose
This study described presenteeism in nursing students from 3 different international nursing programs.

Method
A self-administered survey with open-ended responses was used.

Results
While nearly all student respondents believed going to class and clinical experiences put their classmates and patients at risk, the overall presenteeism rate was 85.5% for class and 69.5% for clinical experiences. Although there were significant differences between universities for reasons for presenteeism, a lack of opportunity for making up missed lecture or clinical time predominated.

Conclusion
Nursing students in 3 culturally different cities reported going to class and clinical experiences while sick despite recognizing the safety risk.
Nursing Students Who Fail and Repeat Courses
Authors: Lewis Lisa S. 
Published: March 2019

Background
Nursing students who fail and are required to repeat courses experience personal consequences and have an impact on the academic institution and nursing profession because of delayed graduation or even attrition.

Purpose
The purpose was to summarize the literature on nursing students who fail and repeat courses and identify gaps in knowledge about this population.

Methods
This was a scoping review.

Results
Academic failure and course repetition have emotional, social, and financial consequences and impact the student, institution, and nursing profession. Nursing student repeaters are at increased risk for poor academic outcomes, but supportive interventions can be beneficial.

Conclusions
The literature lacks a comprehensive description of nursing school progression policies, the incidence of nursing student repeaters, the financial implications of course repetition, and effective interventions to support the academic success of nursing students who repeat courses.
Characteristics of Gay, Bisexual and Other Men Who Have Sex With Men With Multiple Diagnoses of Infectious Syphilis in British Columbia, Canada, 2005–2014
Authors: Konrad Stephanie , Mak Donna B. , Grennan Troy , Zakher Bernadette , Brownrigg Bobbi , Ogilvie Gina , Morshed Muhammad , Tyndall Mark , Gilbert Mark , Krajden Mel , Wong Jason 
Published: March 2019

Background
Infectious syphilis has increased substantially over the past decade. Targeting limited public health resources toward subpopulations with multiple reinfections may have a large impact in reducing onward transmission within a community.

Methods
A chart review was conducted for individuals with 4 or more infectious syphilis diagnoses between 2005 and 2014 (the top 1% of all syphilis diagnoses in British Columbia, Canada). We characterized the sociodemographics, partner notification outcomes and social network.

Results
Between 2005 and 2014, there were 30 individuals with 4 or more syphilis diagnoses, accounting for 139 diagnoses. All were men who have sex with men and 29 (96%) were human immunodeficiency virus–positive. Of the 139 diagnoses, 65% occurred in the early latent stage of infection, 22% in the secondary stage, and 14% in the primary stage. The median number of sexual partners per diagnosis was 5 (range, 1–50). Among the 838 partners reported, 79% were notifiable, 53% were notified, and 23% were reported to be tested or treated. Sexual network mapping showed that almost half of the members of this group could be linked to one another either directly or indirectly via partners over 10 years. Social network mapping demonstrated high connectivity, with 4 venues associated with almost two thirds of the study population.

Conclusions
The connectivity and recurrent diagnoses in this study population suggest potential benefits of targeted interventions to individuals with multiple diagnoses and their partners. Our study highlights the need for enhanced care, increased syphilis testing frequency, and exploring alternative preventative methods among individuals with syphilis rediagnoses to reduce syphilis incidence.
Assessment of Usability and Task Load Demand Using a Robot-Assisted Transfer Device Compared With a Hoyer Advance for Dependent Wheelchair Transfers
Authors: Greenhalgh Mark , Landis James Matthew , Brown Joshua , Kulich Hailee , Bass Sarah , Alqahtani Saleh , Deepak Nikitha , Cryzter Theresa Marie , Grindle Garrett G. , Koontz Alicia M. , Cooper Rory A. 
Published: March 2019

Objective
Manual lifting can be burdensome for people who care for power wheelchair users. Although technologies used for dependent transfers are helpful, they have shortcomings of their own. This study compares the usability and task load demand of a novel robot-assisted transfer device to a clinical standard when performing dependent transfers.

Design
A cross-sectional study was conducted to assess caregivers (N = 21) transferring a 56-kg mannequin with the Strong Arm and Hoyer Advance at three transfer locations. Feedback was gathered through qualitative surveys.

Results
Usability was significant in multiple areas important for transfers. Caregiver fatigue and discomfort intensity were reduced, and the Strong Arm was preferred at the three transfer locations. Device ease and efficiency favored Strong Arm at two stations as was discomfort frequency. In addition, physical demand, frustration, and effort were significantly lower using Strong Arm compared with the Hoyer Advance.

Conclusions
Compared with the Hoyer, participants favored Strong Arm for transfer usability and task load demand. However, further Strong Arm developments are needed.