bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational medicine clinical practice data reveal increased injury rates among Hispanic workers
Authors: Riester Scott M. , Leniek Karyn L. , Niece Ashley D. , Montoya‐Barthelemy Andre , Wilson William , Sellman Jonathan , Anderson Paul J. , Bannister Emily L. , Bovard Ralph S. , Kilbride Karis A. , Koos Kirsten M. , Kim Hyun , McKinney Zeke J. , Abrar Fozia A. 
Published: January 2019

BackgroundMinnesota has an ethnically diverse labor force, with the largest number of refugees per capita in the United States. In recent years, Minnesota has been and continues to be a major site for immigrant and refugee resettlement in the United States, with a large population of both immigrant and native born Hmong, Hispanic, and East Africans. This study seeks to evaluate the injury risk among the evolving minority workforce in the Minnesota Twin Cities region.MethodsA retrospective cohort study identifying work‐related injuries following pre‐employment examinations was performed using electronic health records from a large multi‐clinic occupational medicine practice. Preplacement examinations and subsequent work‐related injuries were pulled from the electronic health record using representative ICD‐10 codes for surveillance examinations and injuries. This study included patient records collected over a 2‐year period from January 1, 2015, through December, 2016. The patients in this cohort worked in a wide‐array of occupations including production, assembly, construction, law enforcement, among others.ResultsHispanic minority workers were twice as likely to be injured at work compared with White workers. Hispanics were 2.89 times more likely to develop back injuries compared with non‐Hispanic workers, and 1.86 times more likely to develop upper extremity injuries involving the hand, wrist, or elbow.ConclusionClinical practice data shows that Hispanic workers are at increased risk for work‐related injuries in Minnesota. They were especially susceptible to back and upper extremity injuries. Lower injury rates in non‐Hispanic minority workers, may be the result of injury underreporting and require further investigation.
Catalytic Enantioselective Ynamide Additions to Isatins: Concise Access to Oxindole Alkaloids
Authors: Moskowitz Max , Wolf Christian 
Published: January 2019

AbstractThe highly enantioselective addition of terminal ynamides to a variety of isatins, catalyzed by a bisoxazolidine copper complex under mild, base‐free reaction conditions, is described. The reaction is broad in scope, scalable, applicable to unprotected isatins, and provides efficient access to 3‐hydroxyoxindoles carrying a tetrasubstituted chiral center with excellent yields and enantioselectivities. Synthetically versatile, multifunctional 3‐hydroxyindolinones are obtained by hydration, partial hydrogenation, or hydroxyacyloxylation of the ynamide moiety at room temperature and exhaustive hydrogenation followed by reductive detosylation and spontaneous cyclization affords cinchonamidine alkaloids.
Formal Aza‐Wacker Cyclization by Tandem Electrochemical Oxidation and Copper Catalysis
Authors: Yi Xiangli , Hu Xile 
Published: January 2019

AbstractIn oxidative electrochemical organic synthesis, radical intermediates are often oxidized to cations on the way to final product formation. Herein, we describe an approach to transform electrochemically generated organic radical intermediates into neutral products by reaction with a metal catalyst. This approach combines electrochemical oxidation with Cu catalysis to effect formal aza‐Wacker cyclization of internal alkenes. The Cu catalyst is essential for transforming secondary and primary alkyl radical intermediates into alkenes. A wide range of 5‐membered N‐heterocycles including oxazolidinone, imidazolidinone, thiazolidinone, pyrrolidinone, and isoindolinone can be prepared under mild conditions.
Adhesion Anisotropy Substrate with Janus Micropillar Arrays Guides Cell Polarized Migration and Division Cycle
Authors: Liu Sidi , Nie Yifeng , Zhang Qiang , Zhu Yuting , Li Xiang , Han Dong 
Published: January 2019

AbstractCell migration is a ubiquitous and important cell behaviour. Construction of an interface that can guide and induce cell migration is of significance for studying cell behaviour and carrying out the transplantation of biological materials. Herein, we prepare a micropillar array by precise modification of two different functional groups on each micropillar unit to obtain a “Janus” structure with anisotropic cell‐adhesion properties. This anisotropic structure was capable of influencing the focal adhesion pathway of melanoma cells as shown by transcriptome sequencing and bioinformatics analysis. This the anisotropic substrate can considerably affect the migration ability of highly invasive melanoma cells. The anisotropic structure with Janus micropillar arrays could also affect the cell division cycle. The experiments showed that the anisotropic microstructures regulate cell migration and are thus of use in the research of cell migration without drug stimulation.
A Self‐Healing Integrated All‐in‐One Zinc‐Ion Battery
Authors: Huang Shuo , Wan Fang , Bi Songshan , Zhu Jiacai , Niu Zhiqiang , Chen Jun 
Published: January 2019

AbstractThe self‐healing of zinc‐ion batteries (ZIBs) will not only significantly improve the durability and extend the lifetime of devices, but also decrease electronic waste and economic cost. A poly(vinyl alcohol)/zinc trifluoromethanesulfonate (PVA/Zn(CF3SO3)2) hydrogel electrolyte was fabricated by a facile freeze/thaw strategy. PVA/Zn(CF3SO3)2 hydrogels possess excellent ionic conductivity and stable electrochemical performance. Such hydrogel electrolytes can autonomously self‐heal by hydrogen bonding without any external stimulus. All‐in‐one integrated ZIBs can be assembled by incorporating the cathode, separator, and anode into hydrogel matrix since the fabrication of PVA/Zn(CF3SO3)2 hydrogel is a process of converting the liquid to quasi‐solid state. The ZIBs show an outstanding self‐healing and can recover electrochemical performance completely even after several cutting/healing cycles.
Aggregation‐Induced Electrochemiluminescence of Carboranyl Carbazoles in Aqueous Media
Authors: Wei Xing , Zhu Meng‐Jiao , Cheng Zhe , Lee Mengjeu , Yan Hong , Lu Changsheng , Xu Jing‐Juan 
Published: January 2019

AbstractThe aggregation‐induced electrochemiluminescence (AIECL) of carboranyl carbazoles in aqueous media was investigated for the first time. Quantum yields, morphologies, and particle sizes were observed to determine the electrochemiluminescence (ECL) performance of these aggregated organic dots (ODs). All compounds exhibit much higher ECL stability and intensity than the carborane‐free compound, demonstrating the essential role of the carboranyl motif. Moreover, the results of cyclic voltammetry (CV) suggest that oxidation/reduction reactions take place at the carboranyl motif. The excited states of ODs were proposed to be generated by the mechanism of surface state transitions. More importantly, these compounds show a reductive–oxidative mechanism in contrast to other organic materials that show oxidative–reductive mechanisms. Our experiments and data have established the relation between AIE organic structures and ECL properties that has a strong potential for biological and diagnostic applications.
Origin of Nitric Oxide Reduction Activity in Flavo–Diiron NO Reductase: Key Roles of the Second Coordination Sphere
Authors: Lu Jiarui , Bi Bo , Lai Wenzhen , Chen Hui 
Published: January 2019

AbstractThe second coordination sphere constitutes a distinguishing factor in the active site to modulate enzymatic reactivity. To unravel the origin of NO‐to‐N2O reduction activity of non‐heme diiron enzymes, herein we report a strong second‐coordination‐sphere interaction between a conserved Tyr197 and the key iron–nitrosyl intermediate of Tm FDP (flavo–diiron protein), which leads to decreased reaction barriers towards N–N formation and N–O cleavage in NO reduction. This finding supports the direct coupling of diiron dinitrosyl as the N–N formation mode in our QM/MM modeling, and reconciles the mechanistic controversy of external reduction between FDPs and synthetic biomimetics of the iron–nitrosyls. This work highlights the application of QM/MM 57Fe Mössbauer modeling in elucidating the structural features of not only first, but also second coordination spheres of the key transient species involved in NO/O2 activation by non‐heme diiron enzymes.
Single‐Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity
Authors: Yang Zhen , Jiang Sheng , Li Feng , Qiu Yatao , Gu Jianhua , Pettigrew Roderic I. , Ferrari Mauro , Hamilton Dale J. , Li Zheng 
Published: January 2019

AbstractInteraction of multiple entities and receptors, or multivalency is widely applied to achieve high affinity ligands for diagnostic and therapeutic purposes. However, lack of knowledge on receptor distribution in living subjects remains a challenge for rational structure design. Herein, we develop a force measurement platform to probe the distribution and separation of the cell surface vascular endothelial growth factor receptors (VEGFR) in live cells, and use this to assess the geometry of appropriate linkers for distinct multivalent binding modes. A tetravalent lead ZD‐4, which was developed from an antitumor drug ZD6474 (Vandetanib) with combined hybrid binding effects, yielded a 2000‐fold improvement in the binding affinity to VEGFR with IC50 value of 25 pm. We confirmed the improved affinity by the associated increase of tumor uptake in the VEGFR‐targeting positron emission tomography (PET) imaging using U87 tumor xenograft mouse model.
Poly(lactic acid) biocomposites with mango waste and organo‐montmorillonite for packaging
Authors: Lima Edla Maria Bezerra , Lima Aline Muniz , Minguita Adriana Paula Silva , Rojas dos Santos Natália Rodrigues , Pereira Ingrid Cristina Soares , Neves Thiago Torres Matta , da Costa Gonçalves Lucas Félix , Moreira Ana Paula Duarte , Middea Antonieta , Neumann Reiner , Tavares Maria Inês Bruno , Oliveira Renata Nunes 
Published: January 2019

ABSTRACTPoly(lactic acid) (PLA) is a biodegradable polymer used in packaging, but its properties can be improved by manufacturing composite matrixes. The combination of PLA, starch, and nano‐montmorillonite leads to materials with superior mechanical properties. Mango lump is rich in cellulose and starch. The goal of this study is to develop and characterize biocomposites based on PLA, mango waste, and nano‐organo‐montmorillonite for packaging. The samples were microstructurally, morphologically, and mechanically characterized. Physical interaction between the phases was observed. The mango components displaced the PLA X‐ray diffraction peaks and the clays altered their intensity, by interfering with chain packing. The addition of single components to PLA increased the samples’ transition temperatures, but the addition of multiple components diminished them. PLA showed adhesiveness to cellulose fibers and nonadhesiveness to starch granules. Thicker samples presented better mechanical properties. PLA–mango–“chocolate clay” samples are relatively stable materials, while PLA–mango–“bofe clay” samples could represent promising highly biodegradable materials. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47512.
Influence of fullerenes on the thermal and flame‐retardant properties of polymeric materials
Authors: Pan Yanqun , Guo Zhenghong , Ran Shiya , Fang Zhengping 
Published: January 2019

ABSTRACTAt present, the application of fullerene in polymer materials has become an attractive issue. Fullerene can enhance the thermal and flame‐retardant properties of polymers due to its high capacity to trap free radicals. Fullerene also has good synergistic effect with inorganic metal flame retardant, intumescent flame retardant, brominated flame retardant (BFR), clay, carbon nanotubes, graphene oxide, and so on. In this review, the impact and mechanism of fullerene and its derivatives on the thermal and flame‐retardant properties of polymeric materials are discussed. And the prospect of fullerene in flame‐retardant polymer composites is also briefly introduced by analyzing the research progress in the recent years. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2020,137, 47538.
Biodegradable poly(lactic acid)/cellulose‐based superabsorbent hydrogel composite material as water and fertilizer reservoir in agricultural applications
Authors: Calcagnile Paola , Sibillano Teresa , Giannini Cinzia , Sannino Alessandro , Demitri Christian 
Published: January 2019

ABSTRACTThe work presents a fully degradable superabsorbent composite material to be used in agricultural and horticultural applications. It is designed to retain and release fertilizer solutions to the soil in a controlled manner, permitting resource optimization. Because of its ability to absorb and release large amounts of saline water, a natural superabsorbent hydrogel derived from cellulose was chosen. Potassium nitrate was chosen to model the fertilizer. Poly(lactic acid) was added to the final composition in order to delay solution release. The composite material was obtained using easily available and low‐cost starting materials and using a simple manufacturing process, using a standard mixer. After being analyzed for morphological (scanning electron microscopy), physical (X‐ray diffraction), chemical (energy‐dispersive X‐ray spectroscopy), and thermal properties (thermogravimetric analysis and differential scanning calorimetry), the material was tested using two different Mediterranean cultivations (Pomodoro di Morciano di Leuca and Cicoria Otrantina) and two different kinds of soil (red and white soils). The analysis revealed different water release characteristics for different soils. These findings have been confirmed by measuring plant growth for both species, as well as fruit yield of the tomatoes. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47546.
Design, synthesis, and antitubercular activity of 3‐amidophenols with 5‐heteroatomic substitutions
Authors: Zhang Niu‐niu , Tang Yun‐xiang , Qian Lu , Gao Ya‐min , Liu Zhi‐yong , Zou Zhi‐liang , Zhang Tian‐yu , Yan Ming 
Published: January 2019

AbstractA series of novel 3‐amidophenols with 5‐heteroatomic substitutions were designed and synthesized. Several compounds showed potent antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC = 0.25–5 μg/mL). Compounds 12j and 14i also displayed good inhibitory activity against M. tuberculosis H37Rv and two clinically isolated multidrug‐resistant M. tuberculosis strains (MIC = 0.39–3.12 μg/mL). The privileged compound 14i showed certain oral efficacy on a mouse infection model. The compounds are non‐cytotoxic against L‐O2 hepatocytes and RAW264.7 macrophagocytes. They did not exert inhibitory activity against representative Gram‐positive and Gram‐negative bacteria.
Synthesis and antimicrobial activity of novel 1,2,3‐triazole‐conjugates of quinazolin‐4‐ones
Authors: Głowacka Iwona E. , Grzonkowski Piotr , Lisiecki Paweł , Kalinowski Łukasz , Piotrowska Dorota G. 
Published: January 2019

AbstractA novel series of diethyl{4‐[(4‐oxoquinazolin‐3(4H)‐yl)methyl]‐1H‐1,2,3‐triazol‐1‐yl}alkylphosphonates 9aa–aj and their respective derivatives substituted at C6 of the quinazolinone moiety with a bromine atom (9ba–bj) or a nitro group (9ca–cj) were synthesized and assessed for the antibacterial activity toward selected Gram‐positive and Gram‐negative bacteria. Their antifungal activity was also screened. Compound 9ac was found to be the most active against Staphylococcus aureus ATCC 6535 (MIC 0.625 mg/mL, MBC 1.25 mg/mL), phosphonates 9ab–ai showed promising activity against Enterococcus faecalis ATCC 29212 (MIC = 0.625 mg/mL, MBC = 1.25 mg/mL), while compounds 9ac–j appeared the most active toward Pseudomonas aeruginosa ATCC 27853 (MIC = 0.625 mg/mL, MBC = 1.25 mg/mL). Antifungal assays of compounds 9aa–aj, 9ba–bj, and 9ca–cj were conducted on Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 and revealed noticeable activity of 9aa–aj (MIC = 1.25 mg/mL).
Imaging Macrophage Phagocytosis Using AIE Luminogen‐Labeled E. coli
Authors: Gu Meijia , Zeng Zixuan , Wu Ming‐Yu , Leung Jong‐Kai , Zhao Engui , Wang Shidong , Chen Sijie 
Published: January 2019

AbstractPhagocytosis of bacteria is an important biological process. Gaining insight into this process may greatly benefit related pathological studies and further contribute to development of therapies for infectious diseases. Tools for studying these internalization processes, however, are limited. Herein, we demonstrate the feasibility of employing an environmentally sensitive aggregation‐induced emission (AIE) probe for bacteria labeling and imaging. By tracking the fluorescence variation of the stained bacteria, the pH changes of its microenvironment can be monitored. In this way, the phagocytic entry of these bacteria into the macrophage cells and the intravacuolar acidification can be visualized in real‐time.
Internal herniation of the abdominal wall
Authors: Bloemen Arthur , J. Keijzers Marlies , L. M. Konsten Joop , Aarts Frits , Vogelaar F. Jeroen 
Published: January 2019

Key Clinical MessageA symptomatic arcuate line hernia should be considered in patients with acute lower abdominal complaints. This rare internal herniation is caused by a sharp ending of the posterior aponeurotic sheath of the rectus muscle, rather than the more common gradual delineation, and can cause strangulation or incarceration of abdominal contents.
Effect of Particle Image Velocimetry Setting Parameters on Local Velocity Measurements in an Agitated Vessel
Authors: Šulc Radek , Ditl Pavel , Jašíkova Darina , Kotek Michal , Kopecký Václav , Kysela Bohuš 
Published: January 2019

AbstractAlthough they are obtained under the same conditions, results on the flow field in an agitated vessel achieved using particle image velocimetry (PIV) may vary due to differences in the PIV conditions. The influence on turbulence characteristics of the main PIV setting parameters, i.e., PIV spatial resolution, sampling frequency, and recording time, was investigated. Tests were performed with three different liquids in a developed turbulent field for a Rushton turbine impeller using two‐dimensional time‐resolved PIV. To obtain the relevant velocity gradients, a minimum recording time is needed. No effect of sampling frequency was observed if the sampling frequency was higher than approximately 17 times the impeller frequency, which is about three times the impeller blade frequency.
Highly Dispersible Hexagonal Carbon–MoS2–Carbon Nanoplates with Hollow Sandwich Structures for Supercapacitors
Authors: Quan Ting , Goubard‐Bretesché Nicolas , Härk Eneli , Kochovski Zdravko , Mei Shilin , Pinna Nicola , Ballauff Matthias , Lu Yan 
Published: January 2019

AbstractMoS2, a typical layered transition‐metal dichalcogenide, is promising as an electrode material in supercapacitors. However, its low electrical conductivity could lead to limited capacitance if applied in electrochemical devices. Herein, a new nanostructure composed of hollow carbon–MoS2–carbon was successfully synthesized through an l‐cysteine‐assisted hydrothermal method by using gibbsite as a template and polydopamine as a carbon precursor. After calcination and etching of the gibbsite template, uniform hollow platelets, which were made of a sandwich‐like assembly of partial graphitic carbon and two‐dimensional layered MoS2 flakes, were obtained. The platelets showed excellent dispersibility and stability in water, and good electrical conductivity due to carbon provided by the calcination of polydopamine coatings. The hollow nanoplate morphology of the material provided a high specific surface area of 543 m2 g−1, a total pore volume of 0.677 cm3 g−1, and fairly small mesopores (≈5.3 nm). The material was applied in a symmetric supercapacitor and exhibited a specific capacitance of 248 F g−1 (0.12 F cm−2) at a constant current density of 0.1 A g−1; thus suggesting that hollow carbon–MoS2–carbon nanoplates are promising candidate materials for supercapacitors.
Ultrafast Single‐Scan 2D NMR Spectroscopic Detection of a PHIP‐Hyperpolarized Protease Inhibitor
Authors: Kiryutin Alexey S. , Sauer Grit , Tietze Daniel , Brodrecht Martin , Knecht Stephan , Yurkovskaya Alexandra V. , Ivanov Konstantin L. , Avrutina Olga , Kolmar Harald , Buntkowsky Gerd 
Published: January 2019

AbstractTwo‐dimensional NMR spectroscopy is one of the most important spectroscopic tools for the investigation of biological macromolecules. However, due to the low sensitivity of NMR spectroscopy, it takes usually from several minutes to many hours to record such spectra. Here, the possibility of detecting a bioactive derivative of the sunflower trypsin inhibitor‐1 (SFTI‐1), a tetradecapeptide, by combining parahydrogen‐induced polarization (PHIP) and ultrafast 2D NMR spectroscopy is shown. The PHIP activity of the inhibitor was achieved by labeling with O‐propargyl‐l‐tyrosine. In 1D PHIP experiments a signal enhancement of a factor of approximately 1200 compared to standard NMR was found. This enhancement permits measurement of 2D NMR correlation spectra of low‐concentrated SFTI‐1 in less than 10 seconds, employing ultrafast single‐scan 2D NMR detection. As experimental examples PHIP‐assisted ultrafast single‐scan TOCSY spectra of SFTI‐1 are shown.
Electrocatalytic Synthesis of Non‐Symmetric Biphenols Mediated by Tri(p‐bromophenyl)amine: Selective Oxidative Cross‐Coupling of Different Phenols and Naphthols
Authors: Wang Qing‐Qing , Jiang Yang‐Ye , Zeng Cheng‐Chu , Sun Bao‐Guo 
Published: January 2019

Summary of main observation and conclusionAn efficient electrochemical access to the non‐symmetric biphenols using tri(p‐bromophenyl)amine (TBPA) as a redox mediator has been developed. The electrochemical protocol features highly selective cross‐coupling products in up to 83% yield, instead of forming homo‐coupling ones.
Shared and differential features of Robo3 expression pattern in amniotes
Authors: Friocourt François , Kozulin Peter , Belle Morgane , Suárez Rodrigo , Di‐Poï Nicolas , Richards Linda J. , Giacobini Paolo , Chédotal Alain 
Published: January 2019

AbstractIn Bilaterians, commissural neurons project their axons across the midline of the nervous system to target neurons on the opposite side. In mammals, midline crossing at the level of the hindbrain and spinal cord requires the Robo3 receptor which is transiently expressed by all commissural neurons. Unlike other Robo receptors, mammalian Robo3 receptors do not bind Slit ligands and promote midline crossing. Surprisingly, not much is known about Robo3 distribution and mechanism of action in other vertebrate species.Here, we have used whole‐mount immunostaining, tissue clearing and light‐sheet fluorescent microscopy to study Robo3 expression pattern in embryonic tissue from diverse representatives of amniotes at distinct stages, including squamate (African house snake), birds (chicken, duck, pigeon, ostrich, emu and zebra finch), early postnatal marsupial mammals (fat‐tailed dunnart), and eutherian mammals (mouse and human). The analysis of this rich and unique repertoire of amniote specimens reveals conserved features of Robo3 expression in midbrain, hindbrain and spinal cord commissural circuits, which together with subtle but meaningful modifications could account for species‐specific evolution of sensory‐motor and cognitive capacities. Our results also highlight important differences of precerebellar nuclei development across amniotes.