bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child Poverty, Child Maintenance and Interactions with Social Assistance Benefits Among Lone Parent Families: a Comparative Analysis
Authors: HAKOVIRTA MIA , SKINNER CHRISTINE , HIILAMO HEIKKI , JOKELA MERITA 
Published: March 2019

AbstractIn many developed countries lone parent families face high rates of child poverty. Among those lone parents who do get child maintenance there is a hidden problem. States may retain all, or a proportion, of the maintenance that is paid in order to offset other fiscal costs. Thus, the potential of child maintenance to alleviate poverty among lone parent families may not be fully realized, especially if the families are also in receipt of social assistance benefits. This paper provides an original comparative analysis exploring the effectiveness of child maintenance to reduce child poverty among lone parent families in receipt of social assistance. It addresses the question of whether effectiveness is compromised once interaction effects (such as the operation of a child maintenance disregard) are taken into account in four countries Australia, Finland, Germany and the UK using the LIS dataset (2013). It raises important policy considerations and provides evidence to show that if policy makers are serious about reducing child poverty, they must understand how hidden mechanisms within interactions between child maintenance and social security systems can work as effective cost recovery tools for the state, but have no poverty reduction impact.
Military refusers and the invocation of conscience: Relational subjectivities and the legitimation of liberal war
Authors: Zehfuss Maja 
Published: March 2019

AbstractDuring the Iraq War, some US soldiers refused (re)deployment. While liberal states appear to protect individuals’ right not to fight against their moral convictions by allowing the right to conscientious objection, those whose objections do not align with the regulations have to break the law in order to follow their convictions. This article explores how the legitimation of liberal war is challenged when we listen to the stories such refusers tell. Focusing on the United States, it briefly sets out the normative context such soldiers faced, highlighting the distinction between permissible conscientious objectors and contemptible deserters. Drawing on Judith Butler, it then focuses on two refusers by reading their own accounts of themselves in their memoirs. Despite not being eligible under the regulations, both invoke their conscience to make their refusal intelligible. By listening to their detailed accounts, the article traces the production and disruption of their subjectivities in relation to the prevailing moral order. Although invoking conscience appears to provide the chance to embrace an authentic self in a bid to resist the problematic moral order, subjectivity remains fractured due to relationality. Put differently, the sovereign subjectivity required by liberal war is simultaneously undermined by it.
Effectiveness of cognitive behavioural group therapy for social anxiety disorder: long-term benefits and aftercare
Authors: Fogarty Ciara , Hevey David , McCarthy Odhrán 
Published: March 2019

AbstractBackground:Empirical research demonstrates the short- to medium-term efficacy and effectiveness of cognitive behavioural group therapy (CBGT) for social anxiety disorder (SAD). Little is known about the durability of gains beyond 1 year following treatment in real-life clinical settings. Literature regarding the impact of aftercare programs as an adjunct to CBGT treatment on SAD is scarce.Aims:To evaluate the long-term effectiveness of CBGT for SAD in a community sample and to explore the relationship between long-term treatment outcomes and aftercare support group attendance.Method:A longitudinal cohort design evaluated changes in standardized psychological measures assessing aspects of SAD, anxiety and depression. Questionnaires were completed before the program (time 1, N = 457), after the program (time 2, n = 369) and at an average of 4.6 years follow-up (time 3, n = 138).Results:Large treatment effect sizes at post-intervention were maintained at long-term follow-up on measures of SAD, anxiety and depression. There was no statistically significant relationship between frequency of attendance at an aftercare support group and degree of improvement from post-treatment severity on any measure.Conclusions:CBGT is an effective intervention in the long-term in a routine clinical setting and should be considered a viable treatment option for SAD. Recommendations for future research, treatment implications and study limitations are considered.
Storm Time Mesoscale Plasma Flows in the Nightside High‐Latitude Ionosphere: A Statistical Survey of Characteristics
Authors: Gabrielse Christine , Pinto Victor , Nishimura Yukitoshi , Lyons Larry , Gallardo‐Lacourt Bea , Deng Yue 
Published: March 2019

AbstractAlthough much work has been done to characterize the global response of Earth's upper atmosphere to geomagnetic storms, much is unknown regarding the response on mesoscales (~30–500 km). In order to understand how the nightside, high‐latitude ionosphere responds on these scales during storms, we have characterized widths, velocities, and occurrence rates of equatorward and poleward mesoscale flows. We characterized them according to main phase versus recovery phase as well as coronal mass ejection (CME) versus high‐speed stream (HSS) storms. Some results include the following: Mesoscale flows are faster during the main phase of the storms. Faster flows >400 m/s are more frequent and probable during CME storms as compared to HSS storms, but more flows occur during HSS storms. Polar cap flows are wider during CMEs than during HSSs. There is a postmidnight preference for polar cap mesoscale flows during storms, especially during recovery phase and during HSSs.
Coseismic and Postseismic Deformation of the 2016 MW 6.2 Lampa Earthquake, Southern Peru, Constrained by Interferometric Synthetic Aperture Radar
Authors: Xu Guangyu , Xu Caijun , Wen Yangmao , Yin Zhi 
Published: March 2019

AbstractWe use Sentinel‐1 radar imagery to explore the coseismic and postseismic surface displacements associated with the 2016 MW 6.2 Lampa earthquake in southern Peru. Based on coseismic interferograms, the preferred slip model links to a blind south southeast striking, south southwest dipping normal fault with a shallow dip (45.2°) and a peak slip of 0.71 m at depth ~5.3 km, which is consistent with seismic solutions. Postseismic interferograms, derived from two tracks of the Sentinel‐1A/B satellites using a small baseline subset method, show subsidence up to ~3 cm in the first year after the mainshock. The kinematic inversions of interferometric synthetic aperture radar (InSAR) observations imply that the postseismic surface displacements observed in 1 year after the earthquake are governed by afterslip occurring along the updip extension of the coseismic slip patches. To further improve the data fitting, we generate a fault with variable strike to refine the kinematic afterslip model. The stress‐driven afterslip forward modeling shows that the postseismic deformation is controlled by afterslip distributed at the edge of the compact coseismic slip area. The surface displacement predictions of the poroelastic rebound show subsidence of the hanging wall, but the magnitude of the displacements is small compared to the observed signal. We as well test a collection of viscoelastic relaxation models and find that the predicted surface displacements are not consistent with the observations. The InSAR results show that the strike of the seismogenic fault is quasi‐parallel to the Vilcanota normal fault system and both the fault associated with earthquake and Vilcanota normal fault dip in the same direction. Therefore, we suspect that the causative fault of this 2016 event may be a normal fault belonging to a “domino” faulting system.
Sea Level Rise in the Samoan Islands Escalated by Viscoelastic Relaxation After the 2009 Samoa‐Tonga Earthquake
Authors: Han Shin‐Chan , Sauber Jeanne , Pollitz Fred , Ray Richard 
Published: March 2019

AbstractThe Samoan islands are an archipelago hosting a quarter million people mostly residing in three major islands, Savai'i and Upolu (Samoa), and Tutuila (American Samoa). The islands have experienced sea level rise by 2–3 mm/year during the last half century. The rate, however, has dramatically increased following the Mw 8.1 Samoa‐Tonga earthquake doublet (megathrust + normal faulting) in September 2009. Since the earthquake, we found large‐scale gravity increase (0.5 μGal/year) around the islands and ongoing subsidence (8–16 mm/year) of the islands from our analysis of Gravity Recovery And Climate Experiment gravity and GPS displacement data. The postseismic horizontal displacement is faster in Samoa, while the postseismic subsidence rate is considerably larger in American Samoa. The analysis of local tide gauge records and satellite altimeter data also identified that the relative sea level rise becomes faster by 7–9 mm/year in American Samoa than Samoa. A simple viscoelastic model with a Maxwell viscosity of 2–3×1018 Pa s for the asthenosphere explained postseismic deformation at nearby GPS sites as well as Gravity Recovery And Climate Experiment gravity change. It is found that the constructive interference of viscoelastic relaxation from both megathrust and normal faulting has intensified the postseismic subsidence at American Samoa, causing ~5 times faster sea level rise than the global average. Our model indicates that this trend is likely to continue for decades and result in sea level rise of 30–40 cm, which is independent of and in addition to anticipated climate‐related sea level rise. It will worsen coastal flooding on the islands leading to regular nuisance flooding.
Impact of Air Pollution Controls on Radiation Fog Frequency in the Central Valley of California
Authors: Gray Ellyn , Gilardoni S. , Baldocchi Dennis , McDonald Brian C. , Facchini Maria Cristina , Goldstein Allen H. 
Published: March 2019

AbstractIn California's Central Valley, tule fog frequency increased 85% from 1930 to 1970, then declined 76% in the last 36 winters. Throughout these changes, fog frequency exhibited a consistent north‐south trend, with maxima in southern latitudes. We analyzed seven decades of meteorological data and five decades of air pollution data to determine the most likely drivers changing fog, including temperature, dew point depression, precipitation, wind speed, and NOx (oxides of nitrogen) concentration. Climate variables, most critically dew point depression, strongly influence the short‐term (annual) variability in fog frequency; however, the frequency of optimal conditions for fog formation show no observable trend from 1980 to 2016. NOx concentration, which has a decreasing north‐south concentration gradient, declined continuously over this period, consistent with the long‐term temporal and spatial trends in fog. As development in the Central Valley increased direct particle and other pollutant emissions from 1930 to 1970, fog frequency increased. Following the Clean Air Act, particle emissions quickly declined, and NOx emissions declined steadily, reducing the cloud condensation nuclei (CCN) available for fog formation. As a precursor of ammonium nitrate aerosols, which are efficient CCN, we used NOx measurements and emission trends as a proxy for the CCN trend. We conclude that while the short‐term fog variability is dominantly driven by climate fluctuations, the longer‐term temporal and spatial changes in fog have been driven by changes in air pollution. For conditions close to the dew point, a decrease in fog of 5 days/year per 10 parts per billion NOx decrease occurred across the Central Valley.
Basin‐Scale Estimate of the Sea‐Air CO2 Flux During the 2010 Warm Event in the Tropical North Atlantic
Authors: Lefèvre Nathalie , Veleda Doris , Tyaquiçã Pedro , Perruche Coralie , Diverrès Denis , Ibánhez J. Severino P. 
Published: March 2019

AbstractFollowing the anomalous warming event occurring in the tropical North Atlantic in 2010, higher than usual surface fugacity of CO2 (fCO2) was observed. To evaluate the spatial extent of these anomalies and their drivers, and to quantify the sea‐air CO2 flux at basin scale, the Mercator‐Ocean model is used from 2006 to 2014 within the region 0–30°N, 70–15°W. Model outputs are generally in accordance with underway sea surface temperature, sea surface salinity, and surface fCO2 recorded by two merchant ships. The anomalous warming of 2010 is well reproduced by the model and is the main driver of fCO2 anomalies. The first coupled Empirical Orthogonal Function mode, between sea surface temperature and fCO2, captures more than 70% of the total variance and is characterized by a basin‐scale warming associated to positive fCO2 anomalies. The corresponding principal components are correlated to the Tropical North Atlantic Index and identify 2010 as the year with the highest positive anomaly over 2006–2014. Exceptions to this general pattern are located near the African coast, where the weakening of the coastal upwelling causes negative inorganic carbon anomalies, and close to the Amazon River plume, where fCO2 anomalies are primarily associated with sea surface salinity anomalies. Although the fCO2 anomalies of 2010 appear mostly in spring, they affect the annual CO2 budget and lead to an increased CO2 outgassing twice as large (46.2 Tg C per year) as the mean annual flux over the 2006–2014 period (23.3 Tg C per year).
Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging
Authors: Krell-Roesch Janina , Vassilaki Maria , Mielke Michelle M. , Kremers Walter K. , Lowe Val J. , Vemuri Prashanthi , Machulda Mary M. , Christianson Teresa J. , Syrjanen Jeremy A. , Stokin Gorazd B. , Butler Lesley M. , Traber Martin , Jack Clifford R. , Knopman David S. , Roberts Rosebud O. , Petersen Ronald C. , Geda Yonas E. 
Published: March 2019

AbstractNeuropsychiatric symptoms (NPS) are a risk factor for cognitive impairment and are associated with cortical β-amyloid (Aβ) deposition. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging to examine the frequency of NPS among cognitively unimpaired (CU) and mild cognitive impairment (MCI) participants who either have normal (A−) or abnormal (A+) Aβ deposition. We also investigated whether combined presence of MCI and amyloid positivity (MCI/A+) is associated with greater odds of having NPS as compared to CU/A− (defined as reference group). Participants were 1627 CU and MCI individuals aged ≥ 50 years (54% males; median age 73 years). All participants underwent NPS assessment (Neuropsychiatric Inventory Questionnaire (NPI-Q); Beck Depression Inventory II (BDI-II); Beck Anxiety Inventory (BAI)) and 11C-PiB-PET. Participants with an SUVR > 1.42 were classified as A+. We conducted multivariable logistic regression analyses adjusted for age, sex, education, and APOE ε4 genotype status. The sample included 997 CU/A−, 446 CU/A+, 78 MCI/A−, and 106 MCI/A+ persons. For most NPS, the highest frequency of NPS was found in MCI/A+ and the lowest in CU/A−. The odds ratios of having NPS, depression (BDI ≥ 13), or anxiety (BAI ≥ 8, ≥ 10) were consistently highest for MCI/A+ participants. In conclusion, MCI with Aβ burden of the brain is associated with an increased risk of having NPS as compared to MCI without Aβ burden. This implies that the underlying Alzheimer’s disease biology (i.e., cerebral Aβ amyloidosis) may drive both cognitive and psychiatric symptoms.
Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy
Authors: He Jiabei , Lee Hong-Jen , Saha Suchandrima , Ruan Diane , Guo Hua , Chan Chia-Hsin 
Published: March 2019

AbstractTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer that harbors enriched cancer stem cell (CSC) populations in tumors. Conventional chemotherapy is a standard treatment for TNBC, but it spares the CSC populations, which cause tumor recurrence and progression. Therefore, identification of the core molecular pathway that controls CSC activity and expansion is essential for developing effective therapeutics for TNBC. In this study, we identify that USP2 deubiquitinating enzyme is upregulated in CSCs and is a novel regulator of CSCs. Genetic and pharmacological targeting of USP2 substantially inhibits the self-renewal, expansion and chemoresistance of CSCs. We show that USP2 maintains the CSC population by activating self-renewing factor Bmi1 and epithelial-mesenchymal transition through Twist upregulation. Mechanistically, USP2 promotes Twist stabilization by removing β-TrCP-mediated ubiquitination of Twist. Animal studies indicate that pharmacological inhibition of USP2 suppresses tumor progression and sensitizes tumor responses to chemotherapy in TNBC. Furthermore, the histological analyses reveal a positive correlation between USP2 upregulation and lymph node metastasis. Our findings together demonstrate a previously unrecognized role of USP2 in mediating Twist activation and CSC enrichment, suggesting that targeting USP2 is a novel therapeutic strategy to tackle TNBC.
Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells
Authors: Marzoq Aseel J. , Mustafa Shakhawan A. , Heidrich Luzia , Hoheisel Jörg D. , Alhamdani Mohamed Saiel Saeed 
Published: March 2019

AbstractPancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment. As part of it, pancreatic stellate cells (PSCs) provide a fibrotic niche, stimulated by a dynamic communication between activated PSCs and tumour cells. Investigating how PSCs contribute to tumour development and for identifying proteins that the cells secrete during cancer progression, we studied by means of complex antibody microarrays the secretome of activated PSCs. A large number of secretome proteins were associated with cancer-related functions, such as cell apoptosis, cellular growth, proliferation and metastasis. Their effect on tumour cells could be confirmed by growing tumour cells in medium conditioned with activated PSC secretome. Analyses of the tumour cells’ proteome and mRNA revealed a strong inhibition of tumour cell apoptosis, but promotion of proliferation and migration. Many cellular proteins that exhibited variations were found to be under the regulatory control of eukaryotic translation initiation factor 4E (eIF4E), whose expression was triggered in tumour cells grown in the secretome of activated PSCs. Inhibition by an eIF4E siRNA blocked the effect, inhibiting tumour cell growth in vitro. Our findings show that activated PSCs acquire a pro-inflammatory phenotype and secret proteins that stimulate pancreatic cancer growth in an eIF4E-dependent manner, providing further insight into the role of stromal cells in pancreatic carcinogenesis and cancer progression.
Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis
Authors: Liu Congmin , Jin Jing , Shi Jin , Wang Liqun , Gao Zhaoyu , Guo Tiantian , He Yutong 
Published: March 2019

Abstract
Background: Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated correlated with clinical outcomes in various cancers. However, the results from each study are insufficient and not completely consistent. Therefore, we perform a systematic meta-analysis to evaluate the value for a feasible biomarker for metastasis and prognosis of cancer. Methods: Relevant English literatures were searched in PubMed, Cochrane Library, Web of science, Embase databases and Chinese literatures were searched in Chinese National Knowledge Infrastructure Wanfang from inception up to 17 April 2018. The pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) using random/fixed-effect were used to identify the relationship between UCA1 and lymph node metastasis (LNM) or overall survival (OS) of cancer patients. Subgroup analysis and sensitivity analysis were performed. The current meta-analysis was performed using Review Manager 5.3 and Stata 12.0 software. Results: A total of 3411 patients from 38 studies were finally included. Patients who with high UCA1 expression suffered from an increased risk of LNM (OR = 2.50; 95% CI: 1.93–3.25). UCA1 was also significantly associated with OS (HR = 2.05; 95% CI: 1.77–2.38). Subgroup analyses across several different variables also showed the similar results in LNM and OS of cancer patients. Conclusion: High expression of UCA1 was linked with poor clinical outcome. UCA1 can serve as a potential molecular marker for metastasis and prognosis in different types of cancers.
Study on liquids diffusion into and relevant corrosion behaviour of glass fibre reinforced polymer used in high voltage composite insulator
Authors: Gao Yanfeng , Liang Xidong , Bao Weining , Wu Chao , Li Shaohua , Liu Yingyan , Cai Yuanji 
Published: March 2019

Long‐term liquids diffusion tests were performed on glass fibre reinforced polymer (GFRP) used in high voltage composite insulator. The plate‐shaped GFRP specimens were immersed in three types of liquids, which high voltage composite insulator would encounter in practice, including deionised water, NaCl solution and nitric acid solution for a period of 4000 h. Chemical reaction and physical dissolution complicated the diffusion processes, which could be divided into three types based on the features of diffusion curves. Fourier transform infrared spectroscopy, scanning electron microscopy and optical interferometry were employed to investigate the chemical property, two‐dimensional (2D) and 3D surface morphologies of GFRP. The results revealed that the surface layer of GFRP was destroyed to some extent depending on the type and concentration of the liquid, the maximum of profile height deviation of GFRP surface was proposed to evaluate the extent of the corrosion of GFRP, the greater the profile height deviation, the more serious the corrosion of GFRP. The present work is helpful for a better understanding of the diffusion behaviour of liquids into GFRP used in high voltage composite insulator as well as in other industry applications.
Green synthesis of Au–Ag alloy nanoparticles using Lysimachia christinae polysaccharide and its application for reducing CO in cigarette mainstream smoke
Authors: Liang Miao , Zhang Guo , Li Ruili , Feng Yajie , Wang Jianmin , Hou Pei 
Published: March 2019

An environmentally friendly and facile method for the synthesis of small‐sized Au–Ag alloy nanoparticles is proposed. The method involves the coreduction of HAuCl4 and AgNO3 using Lysimachia christinae polysaccharide as reductant and stabiliser at 85°C. The synthesised alloy nanoparticles with a mean diameter of 3.81 nm are stable in solution due to the stabilising effect of the polysaccharide. Furthermore, Au–Ag nanoparticles have first been introduced into cigarette filter to serve as a synergistic catalyst for reducing CO in mainstream smoke.