bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Potential of Circulating Tumor Cells in Colorectal Cancer: A Prospective Study
Authors: Baek Dong Hoon , Kim Gwang Ha , Song Geun Am , Han In Sub , Park Eun Young , Kim Hyun Sung , Jo Hong Jae , Ko Sang Hwa , Park Do Youn , Cho Yoon-Kyung 
Published: June 2019

OBJECTIVES:
Circulating tumor cells (CTCs) in the blood have been used as diagnostic markers in patients with colorectal cancer (CRC). In this study, we evaluated a CTC detection system based on cell size to assess CTCs and their potential as early diagnostic and prognostic biomarkers for CRC.

METHODS:
From 2014 to 2015, 88 patients with newly diagnosed CRC, who were scheduled for surgery, and 31 healthy volunteers were enrolled and followed up in Pusan National University Hospital. CTCs were enriched using a centrifugal microfluidic system with a new fluid-assisted separation technique (FAST) and detected by cytomorphological evaluation using fluorescence microscopy.

RESULTS:
Two or more CTCs were detected using FAST in 74 patients and 3 healthy volunteers. The number of CTCs in the CRC group was significantly higher than that in the healthy volunteers (P < 0.001). When a receiver operating characteristic curve was created to differentiate patients with CRC from healthy volunteers, the sensitivity and specificity were almost optimized when the critical CTC value was 5/7.5 mL of blood. When this value was used, the sensitivity and specificity in differentiating patients with CRC from the healthy controls were 75% and 100%, respectively. In patients with CRC with ≥5 CTCs, vascular invasion was frequently identified (P = 0.035). All patients with stage IV were positive for CTCs. Patients with ≥5 CTCs showed a trend toward poor overall and progression-free survival.

DISCUSSION:
Our study demonstrated promising results with the use of FAST-based CTC detection for the early diagnosis and prognosis of CRC.
Cátedra Libre de Pueblos Originarios: 10 años de relaciones interculturales con las comunidades de Tucumán, Argentina
Authors: Sulca Olga Liliana , Segura Zulma 
Published: June 2019

El proyecto Cátedra Libre: Pueblos Originarios se inició en 2009 y sigue vigente dentro del ámbito de la Facultad de Filosofía y Letras de la Universidad Nacional de Tucumán (Argentina). Dicha propuesta se direccionó a atender, por un lado, la diversidad étnica del estudiantado que llega a la Facultad, promoviendo la equidad y fomentando su participación. Y, por otro lado, a interactuar con las diferentes comunidades indígenas autorreconocidas dentro del territorio provincial.
Sin duda que estas experiencias han propiciado una instancia favorable no solo en la inclusión de alumnos indígenas que ingresan a esta unidad académica, sino también en cuanto a situar el conocimiento indígena desde otras epistemologías.
En este espacio de la cátedra confluyeron alumnos indígenas y no indígenas, docentes de los distintos niveles educativos, miembros de las diferentes comunidades indígenas y dirigentes indígenas. El presente trabajo dará cuenta de 10 años de esta experiencia.
En este espacio de la cátedra confluyeron alumnos indígenas y no indígenas, docentes de los distintos niveles educativos, miembros de las diferentes comunidades indígenas y dirigentes indígenas. El presente trabajo dará cuenta de 10 años de esta experiencia.
Loci identification of a N-acyl homoserine lactone type quorum sensing system and a new LysR-type transcriptional regulator associated with antimicrobial activity and swarming in Burkholderia gladioli UAPS07070
Authors: Seynos-García E. , Castañeda-Lucio M. , Muñoz-Rojas J. , López-Pliego L. , Villalobos M. , Bustillos-Cristales R. , Fuentes-Ramírez L. E. 
Published: June 2019

AbstractA random transposition mutant library of B. gladioli UAPS07070 was analyzed for searching mutants with impaired microbial antagonism. Three derivates showed diminished antimicrobial activity against a sensitive strain. The mutated loci showed high similarity to the quorum sensing genes of the AHL-synthase and its regulator. Another mutant was affected in a gene coding for a LysrR-type transcriptional regulator. The production of toxoflavin, the most well known antimicrobial-molecule and a major virulence factor of plant-pathogenic B. glumae and B. gladioli was explored. The absence of a yellowish pigment related to toxoflavin and the undetectable transcription of toxA in the mutants indicated the participation of the QS system and of the LysR-type transcriptional regulator in the regulation of toxoflavin. Additionally, those genes were found to be related to the swarming phenotype. Lettuce inoculated with the AHL synthase and the lysR mutants showed less severe symptoms. We present evidence of the participation of both, the quorum sensing and for the first time, of a LysR-type transcriptional regulator in antibiosis and swarming phenotype in a strain of B. gladioli
Hypergraph-of-entity
Authors: Devezas José , Nunes Sérgio 
Published: June 2019

AbstractModern search is heavily powered by knowledge bases, but users still query using keywords or natural language. As search becomes increasingly dependent on the integration of text and knowledge, novel approaches for a unified representation of combined data present the opportunity to unlock new ranking strategies. We have previously proposed the graph-of-entity as a purely graph-based representation and retrieval model, however this model would scale poorly. We tackle the scalability issue by adapting the model so that it can be represented as a hypergraph. This enables a significant reduction of the number of (hyper)edges, in regard to the number of nodes, while nearly capturing the same amount of information. Moreover, such a higher-order data structure, presents the ability to capture richer types of relations, includingnary connections such as synonymy, or subsumption. We present the hypergraph-of-entity as the next step in the graph-of-entity model, where we explore a ranking approach based on biased random walks. We evaluate the approaches using a subset of the INEX 2009 Wikipedia Collection. While performance is still below the state of the art, we were, in part, able to achieve a MAP score similar to TF-IDF and greatly improve indexing efficiency over the graph-of-entity.
Feature extraction for license plate location based onL0-norm smoothing
Authors: Huang Junqing , Ruzhanshy Michael , Feng Haoxiang , Zheng Lingfang , Huang Xin , Wang Haihui 
Published: June 2019

AbstractWe propose a simple feature extraction algorithm for license plate location, which can reduce the occurrence of pseudo-licenses significantly. Our scheme arises from a novelL0-norm image smoothing, in which the multiple local textures in the complex backgrounds can be suppressed remarkably without changing the structures and edges of the license objects. Due to this “edgeaware” property, we then combine a feature filtering with an efficient binarized image, a simple multi-scale image analysis algorithm, to remove the potential false license plates. Finally, we extract license plates with a projection method. Experimental results show the proposed method provides a flexible and powerful way to the license plate location in complex backgrounds.
Legislating Morality in the US Congress…or Not: Religion, Polarization, and the Next Wave of Culture
Authors: Oldmixon Elizabeth A. 
Published: June 2019

Abstract
Americans routinely petition their legislators for moral redress, drawing the US Congress into cultural debates about who we are as a people and what behaviors and social relationships are compatible with that shared identity. By engaging moral issues, Congress affirms one set of values over another, and legislative behavior is informed by cultural proxies such as religion, ideology, and partisanship. The institution falls short, however, when it comes to crafting lasting, comprehensive policy outputs in this domain. This is because moral issues do not lend themselves to compromise, whereas Congress is structured to seek compromise. The difficulties are exacerbated by party polarization driven by religious and ideological sorting. The upshot is that policymakers are often unable to build the broad coalitions necessary provide policy solutions. Assuming institutional arrangements and levels of polarization remain intact, and barring massive shifts in public opinion or developments in the courts, gridlock on moral issues will likely be the norm.
Biodynamic preparations, greater root growth and health, stress resistance, and soil organic matter increases are linked
Authors: Goldstein Walter A. , Koepf Herbert H. , Koopmans Chris J. 
Published: June 2019

Abstract
The effects of biodynamic preparations were tested in the context of comparisons of conventional, organic, and biodynamic systems and diverse crop rotations in Washington and Wisconsin, USA. Wisconsin research also entailed testing a new nettle-and-manure-based field spray preparation (NCP). Focus was on winter wheat and maize and on soil quality. In Washington, preparations increased root growth of winter wheat, microbial biomass, and soil organic matter. In Wisconsin, applying a combination of preparations that included NCP increased root growth of maize, root health, and particulate organic matter in the soil. Relative to the organic treatments, root dry matter increases associated with the use of preparations varied from 12% to 39% and root length differences varied from 10% to 37% depending on the experiment, crop, year, and preparation application. The biodynamic + NCP treatment also induced substantial, positive yield compensatory effects for maize and wheat under stress condition years. The response slopes were practically identical for wheat and maize, indicating that the effect is of the same magnitude for both crops. Results were higher average grain yields and gross financial returns than for organic grain. The greater root production and root health stimulated by preparations is probably linked to greater vegetative growth, enhanced yield under stress conditions, and increased soil quality and carbon in soils.
Integration of organic sources with inorganic phosphorus increases hybrid maize performance and grain quality
Authors: Ali Muqarrab , Khan Imran , Ali Muhammad Arif , Anjum Shakeel A. , Ashraf Umair , Waqas Muhammad Ahmed 
Published: June 2019

Abstract
Integrative use of organic and inorganic fertilizers not only fulfills the nutritional needs of crops, but also ensures sustainable production and environmental protection. Thus, this study was conducted to determine the influence of phosphorous application from integrated organic and inorganic fertilizers on maize. In this study poultry manure and press mud were integrated with single superphosphate (SSP) as the phosphorus source. Maximum amounts of time to 50% tasseling (47.75 and 47.63 days), 50% silking (53.07 and 53. 11 days) and maturity (106.47 and 106.49 days) were recorded where the recommended dose of phosphorus was applied from only inorganic sources. For application of phosphorus from integrated sources, the treatment containing 25% poultry manure + 75% SSP provided the highest number of grains per cob (459.60 and 460.70), 100-grain weight (26.85 and 27.82), stover yield (9.61 and 10.41 t ha-1), grain yield (7.14 and 7.82 t ha-1) and grain protein content (8.59 and 8.63%) during both years. However, all treatments had non-significant effects on grain oil and starch content. Moreover, in given years, the integrated use of 75% poultry manure and 25% SSP resulted in a maximum benefit-cost ratio of 2.97 and 3.11 USD, respectively, as compared to integrated use of 25% poultry manure and 75% SSP, which produced a benefit-cost ratio of 2.58 and 2.81 USD. In conclusion, integration of organic sources with inorganic phosphorus substantially improves the yield and economics of hybrid maize.
Morbidity and mortality in women with advanced ovarian cancer who underwent primary cytoreductive surgery compared to cytoreductive surgery for recurrent disease: a meta-analysis
Authors: Bartels Helena C. , Rogers Ailin C. , Postle James , Shields Conor , Mulsow Jurgen , Conneely John , Brennan Donal J. 
Published: June 2019

AbstractBackgroundThe primary treatment for advanced ovarian cancer is aggressive cytoreductive surgery (CRS), which is associated with considerable morbidity. The aim of this meta-analysis is to compare morbidity associated with primary CRS and secondary CRS for recurrent disease.MethodsA literature search was performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for publications reporting morbidity and mortality in patients undergoing CRS in primary and recurrent ovarian malignancy. Embase, Medline, Pubmed, Pubmed Central, clinicaltrials. gov and Cochrane databases were searched. Two independent reviewers applied inclusion and exclusion criteria to select included papers. A total of 215 citations were reviewed; 6 studies comprising 641 patients were selected for the analysis.ResultsResults were reported as mean differences or pooled odds ratios (OR) with 95 % confidence intervals (95 % CI). The overall morbidity rate was 38.4 %, and this did not differ between the two groups (p=0.97). This did not change when only Clavien-Dindo grade 3 and 4 morbidities were accounted for (14 % primary CRS, 15 % recurrent, p=0.83). Compared to primary CRS, secondary CRS was associated with a similar operative time (mean 400 min, I2=79 %, p=0.45), rate of bowel resection (I2=75 %, p=0.37) and transfusion requirements (MD – 0.7 L, I2=76 %, p=0.45). The mortality rate in both groups was too low to allow for meaningful meta-analysis, with four deaths in the group undergoing primary cytoreductive surgery (1.0 %) and two deaths in the group with recurrent disease (0.9 %).ConclusionsIn conclusion, secondary CRS for recurrent ovarian cancer is a safe and feasible option in carefully pre-selected patients with comparable morbidity to primary CRS.
Low-grade inflammation causes gap junction-coupled cell dysfunction throughout the body, which can lead to the spread of systemic inflammation
Authors: Hansson Elisabeth , Skiöldebrand Eva 
Published: June 2019

Abstract

Background and aims
Gap junction-coupled cells form networks in different organs in the body. These networks can be affected by inflammatory stimuli and become dysregulated. Cell signaling is also changed through connexin-linked gap junctions. This alteration affects the surrounding cells and extracellular matrix in organs. These changes can cause the spread of inflammatory substances, thus affecting other network-linked cells in other organs in the body, which can give rise to systemic inflammation, which in turn can lead to pain that can turn into chronic.

Methods
This is a review based on literature search and our own research data of inflammatory stimuli that can affect different organs and particularly gap-junction-coupled cells throughout the body.

Conclusions
A remaining question is which cell type or tissue is first affected by inflammatory stimuli. Can endotoxin exposure through the air, water and body start the process and are mast cells the first target cells that have the capacity to alter the physiological status of gap junction-coupled cells, thereby causing breakdown of different barrier systems?

Implications
Is it possible to address the right cellular and biochemical parameters and restore inflammatory systems to a normal physiological level by therapeutic strategies?
Investigation of the Coarse Aggregate Texture Property Using an Improved Laplacian Smoothing Algorithm
Authors: Xu Dongqing , Zhang Dong , Zhuang Xinyi 
Published: June 2019

Abstract
Surface texture is one of the most important morphology properties of coarse aggregates. It has an important effect on the performances of asphalt mixtures, such as the stiffness modulus and high temperature stability. Accurate characterization of the coarse aggregate texture is important for the quality control of coarse aggregates and the design of asphalt mixtures. The two-dimensional (2-D) image analysis method has been used to study the texture property of coarse aggregates in the past two decades. Because of the spatial and mesoscopic properties of the surface texture of coarse aggregates, the traditional 2-D image analysis method is not accurate enough to characterize the texture. In this study, a three-dimensional (3-D) image analysis method (Laplacian smoothing algorithm) was employed to study the coarse aggregate texture property based on the high-precision 3-D image. A minor improvement was added into the Laplacian smoothing algorithm to determine the smoothing scale. Three parameters (deviation limit, iteration number, and smoothness level) are used in the improved Laplacian smoothing algorithm to control the final smoothing result. The 3-D images with the precision of 0.05 mm and 0.1 mm of two sizes of limestone aggregates and two sizes of basalt aggregates were used to study the effect of the three parameters on the smoothing results. The optimal combination of the three parameters was determined based on the parameter study. The results indicate that the deviation limit should be set to 3%, the iteration number should be set to 1, and the smoothness level should be set to 1. A preliminary discussion on the scanning precision was presented based on the 3-D aggregate images with the precision of 0.05, 0.1, 0.2, and 0.5 mm. The results indicate that the 3-D images with average point spacing greater than or equal to 0.2 mm cannot provide sufficient texture details for the evaluation.
Tensile Testing of Carbon FRP (CFRP) and Glass FRP (GFRP) Bars: An Experimental Study
Authors: Khan Qasim S. , Sheikh M. Neaz , Hadi Muhammad N. S. 
Published: June 2019

Abstract
The available ASTM recommends grout-filled steel tube anchors (STAs) for the tensile testing of 6.4- to 32-mm-diameter glass fiber-reinforced polymer (GFRP) bars and a 9.5-mm-diameter carbon FRP (CFRP) bar. The available ASTM provides minimum STA dimensions for tensile testing of the FRP bars. However, because of the large variations in the FRP bars, the exact STA dimensions for successfully testing the FRP bars in tension vary significantly and depend on the type and diameter of the FRP bar. In this experimental study, tensile testing of 9- and 15-mm-diameter CFRP bars and a 15.9-mm-diameter GFRP bar was successfully conducted using cement grout–filled STAs. For the 9-mm-diameter CFRP bar, a STA of 31.8-mm outer diameter (OD), 17.6-mm inner diameter (ID), and 460-mm anchorage length (La) was used. For the 15-mm-diameter CFRP bar, a STA of 46.3-mm OD, 27.1-mm ID, and 600 mm La was used. For the 15.9-mm-diameter GFRP bar, a STA of 46.3-mm OD, 27.1-mm ID, and 460-mm La was used. This study investigated the effect of anchorage length of STAs, number of sand coat layers, and grout age on the tensile stress–strain response of the FRP bars. The experimental results showed that increasing the anchorage length of STAs and the number of layers of sand coating improved the frictional resistance between the FRP bars and the surrounding cement grout, which resulted in rupturing of the FRP bars. The experimental results showed that FRP bars with grout-filled STAs tested at 3 days of casting failed by the rupturing of FRP bars, whereas FRP bars with grout filled STA tested at 28 days of casting slipped out from STAs during the tensile test.
U-shaped relationship between iodine status and thyroid autoimmunity risk in adults
Authors: Wang Bin , He Weiwei , Li Qian , Jia Xi , Yao Qiuming , Song Ronghua , Qin Qiu , Zhang Jin-an 
Published: June 2019

Background
Iodine status has long been regarded as an environmental determinant for thyroid dysfunction, but its relationship with thyroid autoimmunity (TAI) is still controversial. Our study aimed to elucidate the relationship between iodine status and TAI through both a population-based study and a dose–response meta-analysis of eligible epidemiological studies.

Methods
A population-based, cross-sectional study was firstly carried out, which enrolled a total of 2808 Chinese adults. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated through logistic regression analysis. A dose–response meta-analysis of eligible epidemiological studies was also carried out.

Results
The cross-sectional study showed an U-shaped relationship between iodine intake and TAI in adults. Compared with those with more than adequate iodine status, individuals with iodine deficiency, adequate iodine status and iodine excess all had higher risk of TAI, and the adjusted ORs were 1.50 (95% CI 1.03–2.17, P = 0.032), 1.50 (95% CI 1.09–2.07, P = 0.013) and 1.68 (95% CI 1.11–2.53, P = 0.014), respectively. The dose–response meta-analysis included 22 epidemiological studies with a total of 69,987 participants and further validated the U-shaped relationship between iodine intake and TAI in adults, which proved the significantly increased risk of TAI among individuals with either iodine deficiency or iodine excess. Stratified analysis of studies with low risk of confounding bias also identified similar findings.

Conclusion
The study suggests an U-shaped relationship between iodine intake and TAI in adults, and both iodine deficiency and iodine excess are risk factors of TAI in adults. The underlying mechanisms need to be elucidated in future studies.
ANALISIS TECHNOLOGY ACCEPTANCE MODEL PADA APLIKASI PLATFORM PERDAGANGAN ELEKTRONIK DI KALANGAN MAHASISWA
Authors: Fiyah Nur , Mayangky Nissa Almira , Hadianti Sri , Riana Dwiza 
Published: June 2019

Shopee merupakan platform perdagangan elektronik yang didirikan pada tahun 2009 sebagai pasar mobile-sentris sosial yang pertama dimana pengguna aplikasi shopee ini dapat melakukan belanja, menjual, dan menjelajahi kapan saja melalui ponsel pintar dengan aman dan praktis. Aplikasi Shopee dipengaruhi dari beberapa faktor untuk menghasilkan sistem belanja yang sesuai dengan kebutuhan penggunanya, tidak menutup kemungkinan bahwa masih ada pengguna yang merasa dikecewakan dengan pelayanan Shopee, hal inilah yang membuat para pengguna aplikasi merasa dikecewakan.Untuk meningkatkan kemudahan dan kenyamanan pengguna sistem maka perlu adanya pengukuran yang mendalam mengenai faktor mana yang mempengaruhi sikap penerimaan pengguna aplikasi Shopee di kalangan Mahasiswa. Metode penelitian menggunakan eksploratory dengan jumlah responden sebanyak 100 orang mahasiswa. Teknik analisis data menggunakan technology acceptance model (TAM). Hasil penelitian menunjukkan bahwa faktor Perceived usefulness, Perceived ease of use, Attitude, dan Intention to use semua berpengaruh signifikan pada penerimaan penggunaan aplikasi shopee dikalangan Mahasiswa. Hasil pengujian secara keseluruhan yang dihasilkan R squares adjusted sebesar 0.550 atau 55% dengan nilai T value pada Perceived ease of use terhadap Attitude memiliki nilai sebesar 7.861, Perceived ease of useterhadap Perceived ease of use memiliki nilai sebesar 9.777, Attitude terhadap Intention to use memiliki nilai sebesar 8.476 sehingga hasil ini menunjukkan bahwa nilai T value lebih besar dari taraf signifikansi 5% dan dapat diambil kesimpulan bahwa faktor Perceived usefulness, Perceived ease of use, Attitude, dan Intention to use saling berpengaruh signifikan terhadap pengguna aplikasi Shopee di kalangan Mahasiswa.