bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical study of MEMS/NEMS Force Sensor for Microbotics Applications
Authors: Lamba Monica , Chaudhary Himanshu , Singh Kulwant 
Published: September 2019

Abstract
The purpose of this paper is design, virtual fabrication and simulation of microcantilever based Force sensor using Comsol Multiphysics Software version 5.3a to perform analytical analysis of MEMS/NEMS based sensor for microbotic applications.Piezoresistive MEMS Force sensor having dimension of fixed part is 1000 µm
2 with height of 50µm and movable part is 600 µm length, 500µm breadth and 20 µm height.The analysis of force sensor is observed by plotting a curve between force and voltage, Displacement and Voltage and Sensitivity. The range of force measured by this sensor is from 10N to 1µN, the simulating result shows that a very wide range of force can be measured by this single sensor. The force measurement at microscale has been very common in microbotics for micromanipulation . The simulated MEMS force sensor having resolution 0.1µN using piezoresistive sensing which is improved then the previous work. This range of force, resolution and sensitivity can be used for the application of two –fingered microgripper in microbotic system.Mathematically, dynamic frequency range for microcatilever based force sensor is calculated in range of 1.477076 KHz to 467.935969KHz, along with its different frequency harmonics for force 10N-100µN.Here, microcatilever is used for the measurement of force by using piezoresistors which are arranged in voltage divider sensing technique to obtain higher resolution, sensitivity and wide and lower range of force.
A retrofit design of safety and stability mechanism for two wheelers
Authors: Nitin C M , Patil Santosh 
Published: September 2019

Abstract
This paper presents an idea of a retrofit design of a mechanism which helps in achieving the safety and stability of the two wheeler vehicle. The aim of the mechanism is to avoid the two wheeler from fall/skid and also work as an attachment for physically challenged drivers. The mechanism is a hydraulic system clubbed with linkages, where an extra two small sized wheels are grounded to provide safety from fall and give stability to the two wheeler. The proposed retrofit mechanism would replace the double stand of the vehicle. These extra wheels move along with the vehicle, hence providing the required stability. This forms a replacement of the costly attachments which the physically challenged drivers add to their vehicles. The shock absorbers would be included accordingly in the mechanism. The probable improvements on deploying the said mechanism on a two wheeler will provide easy riding, as the vehicle self-stabilize itself when the small wheels are grounded. This helps the less abled riders to easily ride the vehicle with no worries of grounding their feet. A number of designs were developed, studied and three designs were shortlisted based on the feasibility of the mechanism. Finally, a better design is proposed for further improvement and implementation.
Analysis of an inventory model with both the time dependent holding and sales revenue cost
Authors: Malik A. K. , Mathur Priya , Kumar Satish 
Published: September 2019

Abstract
The research paper explores the possibility of long-life products on inventory model with variable demand rate. We established a new scheme for maximum life time product; their deterioration rate is considered as a function of maximum life time. The main conception behind the planned model is: time dependent both holding and sales revenue cost for finding the optimal total profit with the optimal cycle. Finally, numerical example and sensitivity analysis demonstrate that the proposed mathematical model result and realize the effect of variation in optimal profit function with respect to several parameters used.
Description, Biology, and Impact of the Fruit-Feeding Moth, Mompha luteofascia sp. n. (Lepidoptera: Momphidae), on Miconia calvescens (Melastomataceae) in Costa Rica
Authors: Alfaro-Alpízar Manuel Antonio , Koster Sjaak J C , Johnson M Tracy , Badenes-Pérez Francisco Rubén 
Published: September 2019

AbstractFruits of Miconia calvescens DC. (Melastomataceae) were dissected to study insect frugivory in this plant in its native habitat in Costa Rica. Larvae of an unknown Mompha species (Lepidoptera: Momphidae), Anthonomus monostigma Champion (Coleoptera: Curculionidae), and unidentified Diptera and Hymenoptera were found in M. calvescens fruits. The Mompha species, described here as new as Mompha luteofascia Koster & Badenes-Pérez, was the most abundant insect frugivore in M. calvescens, infesting up to 38.1% of the fruits sampled. Feeding damage by M. luteofascia was positively correlated with fruit maturity, and resulted in significantly reduced numbers of seeds and rates of seed germination. Miconia calvescens fruits with medium damage (50–75% of the pulp missing) and high damage (75–100% of the pulp missing) had an average of 96 and 99 seeds, respectively, whereas undamaged fruits contained an average of 127 seeds per fruit. In fruits with medium and high fruit damage, only 1.9 and 0.1% of the seeds germinated, respectively, whereas 34.8% of the seeds germinated in undamaged fruits. Mompha luteofascia developed through three instars, as determined from measurement of head capsules. Larvae usually fed as one individual per each fruit attacked, exiting fruit to pupate in foliage or litter. Parasitism of M. luteofascia larvae was substantial, averaging 64 and 38% at the two study sites. Although host specificity of M. luteofascia has not been evaluated, the significant reductions in seed numbers and seed germination caused by its larvae indicate that this species deserves further assessment as a potential biological control agent of M. calvescens.
Ovule and seed production patterns in relation to flower size variations in actinomorphic and zygomorphic flower species
Authors: Mochizuki Jun , Itagaki Tomoyuki , Aoyagi Blue Yuta , Ito Masaya , Sakai Satoki 
Published: September 2019

Abstract
Zygomorphic flower species tend to show lower flower size variation than actinomorphic flower species. Have these differences also brought an association in ovule and seed production that has arisen due to natural selection in these species? Flowers were collected from 29 actinomorphic and 20 zygomorphic flower species, and fruits were collected from 21 actinomorphic and 14 zygomorphic flower species in Miyagi and Aomori prefectures, in Japan. The coefficient of variations (CVs) of flower sizes, mean ovule sizes of flowers, ovule numbers of flowers and mean seed sizes of fruits were calculated. The CV of flower sizes was marginally different between the floral symmetry types; tending to be lower in the zygomorphic flower species than in the actinomorphic flower species. The CVs of mean ovule sizes and ovule numbers of flowers increased with increase in the CV of flower sizes in the actinomorphic flower species but not in the zygomorphic flower species. Mean ovule number of flowers tends to increase with increase in mean flower size in the actinomorphic flower species but not in the zygomorphic flower species. The degrees in variations in ovule size and number of flowers were influenced by the interaction of floral symmetry type and flower size variation, suggesting that floral symmetry also has brought an evolutionary association in ovule production by flowers.
Patterns of Performance and Symptom Validity Test Findings After Mild Traumatic Brain Injury
Authors: Donders Jacobus , Lefebre Nathan , Goldsworthy Rachael 
Published: September 2019

Abstract

Objective
The purpose of this study was to evaluate the presence of demographic, injury and neuropsychological correlates of distinct patterns of performance validity test and symptom validity test results in persons with mild traumatic brain injury (mTBI).

Method
One hundred and seventy-eight persons with mTBI completed the Test of Memory Malingering (TOMM; performance validity) and the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; symptom validity) within 1–12 months postinjury. Four groups were compared: (a) pass both TOMM and MMPI-2-RF validity criteria, (b) pass TOMM and fail MMPI-2-RF, (c) fail TOMM and pass MMPI-2-RF, and (d) fail both TOMM and MMPI-2-RF.

Results
Compared to Group a, participants in combined Groups b–d were more than twice as likely to be engaged in financial compensation-seeking and about four times less likely to have neuroimaging evidence of an intracranial lesion. The average performance of Group d on an independent test of verbal learning was more than 1.5 standard deviations below that of Group a. Participants in Group b were more likely to have intracranial lesions on neuroimaging than participants in Group c.

Conclusion
Performance and symptom validity tests provide complementary and non-redundant information in persons with mTBI. Whereas financial compensation-seeking is associated with increased risk of failure of either PVT or SVT, or both, the presence of intracranial findings on neuroimaging is associated with decreased risk of such.
SCSsim: an integrated tool for simulating single-cell genome sequencing data
Authors: Yu Zhenhua , Du Fang , Sun Xuehong , Li Ao 
Published: September 2019

Abstract

Motivation
Allele dropout (ADO) and unbalanced amplification of alleles are main technical issues of single-cell sequencing (SCS), and effectively emulating these issues is necessary for reliably benchmarking SCS-based bioinformatics tools. Unfortunately, currently available sequencing simulators are free of whole-genome amplification involved in SCS technique and therefore not suited for generating SCS datasets. We develop a new software package (SCSsim) that can efficiently simulate SCS datasets in a parallel fashion with minimal user intervention. SCSsim first constructs the genome sequence of single cell by mimicking a complement of genomic variations under user-controlled manner, and then amplifies the genome according to MALBAC technique and finally yields sequencing reads from the amplified products based on inferred sequencing profiles. Comprehensive evaluation in simulating different ADO rates, variation detection efficiency and genome coverage demonstrates that SCSsim is a very useful tool in mimicking single-cell sequencing data with high efficiency.

Availability and implementation
SCSsim is freely available at https://github.com/qasimyu/scssim.

Supplementary information
Supplementary data are available at Bioinformatics online.
Antibiotic Prescribing Variability in a Large Urgent Care Network: A New Target for Outpatient Stewardship
Authors: Stenehjem Edward , Wallin Anthony , Fleming-Dutra Katherine E , Buckel Whitney R , Stanfield Valoree , Brunisholz Kimberly D , Sorensen Jeff , Samore Matthew H , Srivastava Raj , Hicks Lauri A , Hersh Adam L 
Published: September 2019

Abstract
Improving antibiotic prescribing in outpatient settings is a public health priority. In the United States, urgent care (UC) encounters are increasing and have high rates of inappropriate antibiotic prescribing. Our objective was to characterize antibiotic prescribing practices during UC encounters, with a focus on respiratory tract conditions. This was a retrospective cohort study of UC encounters in the Intermountain Healthcare network. Among 1.16 million UC encounters, antibiotics were prescribed during 34% of UC encounters and respiratory conditions accounted for 61% of all antibiotics prescribed. Of respiratory encounters, 50% resulted in antibiotic prescriptions, yet the variability at the level of the provider ranged from 3% to 94%. Similar variability between providers was observed for respiratory conditions where antibiotics were not indicated and in first-line antibiotic selection for sinusitis, otitis media, and pharyngitis. These findings support the importance of developing antibiotic stewardship interventions specifically targeting UC settings.
Therapeutic Drug Monitoring of Biologics During Induction to Prevent Primary Non-Response
Authors: Sparrow Miles P , Papamichael Konstantinos , Ward Mark G , Riviere Pauline , Laharie David , Paul Stephane , Roblin Xavier 
Published: September 2019

Abstract
Biologic therapies have revolutionized the management of inflammatory bowel disease [IBD], but primary and secondary non-responses occur in a significant proportion of patients. Therapeutic drug monitoring [TDM] now has an established role in the treatment algorithm for managing secondary loss of response to anti-tumour necrosis factor [anti-TNF] agents during maintenance therapy. Data to support the use of TDM in the management of secondary loss of response to vedolizumab and ustekinumab are emerging. The potential to prevent primary non-response to biologic agents during induction is of equal, and potentially greater, clinical importance. Again, most data supporting the use of ‘proactive' TDM during induction pertains to the use of anti-TNF agents, but signals of efficacy for the use of TDM during induction with other biologic classes are now appearing. This review aims to summarize data on the use of TDM during induction to prevent pharmacokinetic primary non-response to all three classes of biologic therapy currently available for the treatment of IBD.
Varieties of Affluence: How Political Attitudes of the Rich Are Shaped by Income or Wealth
Authors: Arndt H Lukas R 
Published: September 2019

AbstractSociological research often uses income as the only indicator to describe or proxy the group of the rich. This article develops an alternative framework in order to describe varieties of affluence as three-dimensional: depending on income, wealth, and origin of wealth. The relevance of such a multidimensional perspective for social outcomes is demonstrated by analysing the heterogeneity in political attitudes between different varieties of affluence. For this purpose, ordinary least squares regressions are applied to a sample from 2005, 2009, and 2014 German Socio-Economic Panel (GSOEP). The main results are, first, that the perspective of varieties of affluence reveals significant differences in social outcomes as demonstrated by political attitudes. Especially wealth possession is related to significantly more right political attitudes. Second, there is strong explorative evidence that the rich in Germany should be regarded as a heterogeneous group. These findings are robust to influential data, multiple imputations of wealth data, and endogeneity due to pooled data. The article concludes, among other things, that more data are required to make more certain assertions.
Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment
Authors: Caillaud Marie , Hudon Carol , Boller Benjamin , Brambati Simona , Duchesne Simon , Lorrain Dominique , Gagnon Jean-François , Maltezos Samantha , Mellah Samira , Phillips Natalie ,   Consortium for the Early Identification of Alzheimer’s Disease-Quebec, Belleville Sylvie 
Published: September 2019

Abstract

Objective
The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer’s disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.

Method
We included 126 participants from the Consortium for the Early Identification of Alzheimer’s disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).

Results
Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.

Discussion
As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD’s hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.
No Percolation at Criticality on Certain Groups of Intermediate Growth
Authors: Hermon Jonathan , Hutchcroft Tom 
Published: September 2019

Abstract
We prove that critical percolation has no infinite clusters almost surely on any unimodular quasi-transitive graph satisfying a return probability upper bound of the form $p_n(v,v) \leq \exp \left [-\Omega (n^\gamma )\right ]$ for some $\gamma&gt;1/2$. The result is new in the case that the graph is of intermediate volume growth.
Fock Space Representation of the Circle Quantum Group
Authors: Sala Francesco , Schiffmann Olivier 
Published: September 2019

Abstract
In [12] we have defined quantum groups $\mathbf{U}_{\upsilon }(\mathfrak{sl}(\mathbb{R}))$ and $\mathbf{U}_{\upsilon }(\mathfrak{sl}(S^1))$, which can be interpreted as continuum generalizations of the quantum groups of the Kac–Moody Lie algebras of finite, respectively affine type $A$. In the present paper, we define the Fock space representation $\mathcal{F}_{\mathbb{R}}$ of the quantum group $\mathbf{U}_{\upsilon }(\mathfrak{sl}(\mathbb{R}))$ as the vector space generated by real pyramids (a continuum generalization of the notion of partition). In addition, by using a variant version of the “folding procedure” of Hayashi–Misra–Miwa, we define an action of $\mathbf{U}_{\upsilon }(\mathfrak{sl}(S^1))$ on $\mathcal{F}_{\mathbb{R}}$.
Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells
Authors: Chen Nathan H , Ong Cheryl-Lynn Y , O’Sullivan Jonathan , Ibranovic Ines , Davey Krystelle , Edwards Jennifer L , McEwan Alastair G 
Published: September 2019

Abstract
L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.
Virological Factors Associated with the Occurrence of HBV Reactivation in Patients with Resolved HBV Infection Analyzed through Ultradeep Sequencing
Authors: Sakamoto Kazumasa , Umemura Takeji , Ito Kiyoaki , Okumura Akinori , Joshita Satoru , Ota Masao , Sugiyama Masaya , Mizokami Masashi , Yoneda Masashi , Tanaka Eiji 
Published: September 2019

Abstract

Background
Hepatitis B virus reactivation (HBVr) is an important complication of immunosuppressive drug therapy. It can occur via both virological and host factors; however, the underlying mechanisms remain largely unknown.

Methods
We examined serum samples derived from patients with HBVr and those with acute hepatitis B (AHB). HBV DNA was amplified the targeted nucleic acid molecule and analyzed by next-generation sequencing.

Results
The percentage of patients infected with genotype Bj among the HBVr patients was significantly higher than that in the AHB patients. The frequency of mutation sites in the whole HBV genome, especially in the envelope region, in the HBVr was significantly higher than that in the AHB. The prevalence of the S3N amino acid substitution in the envelope protein and mutations at positions G1896A and G1899A in the precore region were significantly higher in the HBVr compared to AHB. The population of S3N aa substitution and nt G1896A and G1899A mutations in each individual showed quite a similar percentage of occurrence.

Conclusions
We identified specific virological factors in patients with HBVr through ultra-deep sequencing. Our findings would be beneficial for the elucidation of mechanisms underlying HBVr development and for disease control.
Theorizing Religion and the Public Sphere: Affect, Technology, Valuation
Authors: Hamner M Gail 
Published: September 2019

AbstractReligion scholars require a theory of public encounter that is evental, technological, and affective. Instead of a spatial public sphere, today’s encounters occur through technological mediations that are affective and image-laden. This essay examines the latter “publicness” and illustrates its roles as an affective technology of whiteness as that which frames and distributes the persevering powers of, and reluctantly tracks resistances to, white supremacy. Film is a fruitful cultural site for examining the whiteness of publicness. The essay turns to Moonlight (Jenkins, 2016) to demonstrate how film can resist and interrupt normative whiteness and to show how this transvaluative cultural labor can be seen as religious. The essay conceptualizes religion as a hinged form and function through which subjects and publics co-emerge and by which social and sedimented valuations are (re)bound. Grappling with religion as social forms and functions of valuation opens it to algorithmic variability that mandates attention to circulations of power as both capacity and intensity.
Long-term impacts of antibiotic allergy testing on patient perceptions and antibiotic utilization
Authors: Tan N , Holmes N E , Chua K Y , Stewardson A J , Trubiano J A 
Published: September 2019

Abstract

Objectives
To define the long-term impacts of antibiotic allergy testing (AAT) on patient allergy perception and antibiotic utilization.

Methods
Patients were identified from a prospective AAT database as having completed testing during a 15 month period beginning January 2017. Patients were contacted for a follow-up survey at least 12 months post-AAT. For those contacted, baseline demographics, antibiotic allergy label (AAL) history, age-adjusted Charlson comorbidity index, infection history, antibiotic de-labelling (≥1 AAL removed following AAT) and antibiotic usage for 12 months prior to testing (pre-AAT) and 12 months following testing (post-AAT) were recorded for each patient.

Results
From the follow-up survey of 112 patients post-AAT, 95.2% (59/62) of patients with complete AAL removal expressed willingness to use ‘de-labelled’ antibiotics and 91.9% (57/62) were adherent to allergy label modification. Comparing antibiotic utilization 12 months pre-AAT versus 12 months post-AAT, AAT was associated with a significant increase in preferred antibiotic therapy [adjusted odds ratio (aOR) 3.29, 95% CI 1.56–6.92] and reduction in restricted antibiotic utilization (aOR 0.42, 95% CI 0.19–0.93).

Conclusions
An antimicrobial stewardship (AMS)-led AAT programme was safe and effective in the long term in the promotion of preferred and narrow-spectrum antibiotic usage, and favourable patient perception towards the AAT testing results was identified. This study further supports the routine incorporation of AAT into AMS programmes, confirming safety and durability of testing impacts on patients as well as increasing preferred antibiotic utilization.