bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Outcomes of Haemorrhoidectomy along With Suture Haemorrhoidopexy in Multiple Haemorrhoids
Authors: Khalil Mohammad Ibrahim , Rahman Md Ashiqur , Ahmed Adnan , Uddin Samia Shihab , Alauddin Mohammad , Alam ABM Khurshid , Hossain AZM Mostaque 
Published: September 2019

Background: Haemorroid stapler becomes easier and safe to deal multiple and prolapsed haemorrhoid at a time.
Objectives: The purpose of the present study was to evaluate the outcome of suture haemorrhoidopexy for secondary position haemorrhoids in addition to haemorrhoidectomy for primary haemorrhoids (multiple).
Methodology: This prospective interventional study was performed in Dhaka Medical College Hospital, Dhaka, Bangladesh and in a private hospital in Gazipur, Bangladesh for over five (05) years from January 2012 to December 2016. Patients who were presented with secondary position haemorrhoids in addition to primary position haemorrhoids (multiple haemorrhoids) were included in this study. Open haemorrhoidectomy (Milligan-Morgan) followed by suture haemorrhoidopexy was done. All patients were followed up after 1, 2, 4, 8 weeks, 6 months and 1 yearly.
Result: Total 18 patients were operated. Among those immediate complications were encountered in patients in the form of per rectal bleeding 1(5.55%), pain 3(visual pain scale 4)16.66%, mucosal oedema 6(33.33%), no patient developed early postoperative prolapse. No patient developed bowel incontinence. Late complications experienced as prolapse at 1 year follow up which was treated by conservative measures. No patient developed anal stenosis. Mean operating time was 25 minutes and duration of hospital stay was 1 day.
Conclusion: Stapled haemorrhoidopexy is a safe procedure for circumferential excision of mucosa and submucosa dealing all haemorrhoids and prolapse simultaneously.
Journal of Current and Advance Medical Research 2019;6(2): 73-76
Association of Serum Albumin Level in Predicting of Preeclampsia among Pregnant Women in Dhaka City of Bangladesh
Authors: Begum Taslima , Habib Md Anwar , Chaudhury Shipra , Akter Hasina , Firdousi Tahmida , Hafez Fahmida , Mohammad Nur , Amin ABM Ruhul 
Published: September 2019

Background: Serum albumin level is very important during the pregnancy for the good outcome of delivery.
Objective: The purpose of the present study was to see the association of serum albumin level in predicting of preeclampsia among the pregnant women.
Methodology: This descriptive cohort study was conducted in the OPD of the Department of Obstetrics and Gynaecology at Rajshahi Medical College Hospital, Rajshahi, Bangladesh from January 2013 to December 2014 for a period of two (2) years. This study was carried on pregnant woman attending in outdoor department of Gynaecology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh before 20 weeks of pregnancy who were healthy normotensive primigravidae with singleton pregnancy. Healthy normotensive primigravidae with singleton pregnancy were enrolled in this study before 20th weeks and were followed up after 28th weeks of pregnancy. The data of serum albumin in gm/dL before 20th weeks and after 28th weeks of pregnancy were collected.
Result: A total number of 75 pregnant women were finally included in this study. PE was identified in 12(16%) women out of 75 patients on the basis of one or more following parameters. Mean serum albumin in 1st visit was 3.84±0.41 gm/dL. No association was found between development of preeclampsia and levels of serum albumin in early trimester of pregnancy (p=0.960).
Conclusion: In conclusion serum albumin level is not a predictor of development of preeclampsia among the pregnant women in early stage.
Journal of Current and Advance Medical Research 2019;6(2):83-86
Female Factors related with Infertility and Their Pregnancy Outcome after Intrauterine Insemination: Experience of 790 Cases in Bangladesh
Authors: Khanam Shafeya , Khanam Rehana , Shuvro Muqsuda Ashraf , Shati Morium Faruque , Obayed Trifa 
Published: September 2019

Background: Several female factors are related with the cause of infertility.
Objectives: The purpose of the present study was to assess female factors related with infertility and their pregnancy outcome after intrauterine insemination.
Methodology: This prospective cohort study was carried out at a private infertility centre (Central Hospital Limited, Dhaka) in Dhaka city of Bangladesh from January 2012 to December 2017 for a period of 6 years. Infertile couples who already had undergone natural cycles of super-ovulation for six months or whose duration of infertility was more than one year were included. Infertile women were evaluated and the causes of infertility were assessed. The follow up was performed to see the pregnancy outcome.
Result: A total number of 790 women were recruited. The mean age with standard deviation of study population was 28.94±5.386 years. Among 790 infertile women 12 women were become pregnant after IUI. Among these 12 women female factors of infertility was present in 8(66.7%) cases and the rest 4(33.3%) cases were absent. However, 778 women could not pregnant after IUI and among these 277(35.6%) cases had the presence of female factors and the rest 501(64.4%) cases had absence of female infertility causes. The presence of female factor had 3.62 (95% CI 1.08-12.12) times more risk to become pregnant among the infertile women after IUI (p=0.026). Among 790 infertile women 285(36.1%) women had presence of female infertility factors.
Conclusion: In conclusion female factors are significantly related with infertility and their pregnancy outcome after intrauterine insemination.
Journal of Current and Advance Medical Research 2019;6(2):87-91
Comparison of Clinical Foetal Weight and Ultrasonography Detected Foetal Weight
Authors: Firdousi Tahmida , Begum Taslima , Hafez Fahmida , Mohammad Nur , Ahmad Ashfaq , Amin ABM Ruhul 
Published: September 2019

Background: Comparison of foetal weight detection between clinical examination and ultrasonography is very important. Objective: The purpose of the present study was to compare the detection of foetal weight between clinical examination and ultrasonography.
Methodology: This cross-sectional comparative study was carried out in the Department of Obstetrics & Gynaecology at Rajshahi Medical Hospital Hospital (RMCH), Rajshahi, Bangladesh from July 2012 to June 2014 for a period of 2(two) years. Pregnant women with known gestational age at term (38 to 40 weeks of pregnancy), singleton pregnancy with longitudinal lie were included in this study. The clinical estimation of foetal weight was done. Foetal weight was estimated by using Johnson’s formula. The patient was then taken to Dept. of Radiology & Imaging, RMCH. Ultrasonographic estimation of foetal weight was done from estimation of foetal abdominal circumference (AC), biparietal diameter (BPD) and foetal femur length (FL). All the weights measured by ultrasound were recorded in the data sheet.
Result: A total number of 245 pregnant women in term pregnancy were recruited as per inclusion and exclusion criteria. Table 1 shows age distribution of the study subjects. The mean age was 26.42 (SD ± 4.46). Low birth weight was found 12(4.9%) cases in ultrasonographic examination and 14(5.7%) cases in clinical measurement. Overweight was found 13(5.2%) cases in ultrasonographic examination and 16(6.5%) cases in clinical measurement. The mean with SD of birth weight among the study population were 3283.27±461.05 gram and 2870.41±424.84 gram in clinical and Ultrasonographic examination respectively (p < 0.05).
Conclusion: In conclusion clinical estimation of foetal weight is significant differed with the measurement of USG.
Journal of Current and Advance Medical Research 2019;6(2):92-96
Antimicrobial Activity of <i>N</i>-ariliden(alkylidene)hydrazides of Carboxymethylalginic Acid
Authors: Kosareva D. N. , Ananieva E. P. , Iozep A. A. 
Published: September 2019

Introduction. Nowadays, due to the emergence of new broad-spectrum antibiotics and synthetic chemotherapeutic agents, the use of nitrofuran has significantly decreased. At the same time, they remain important for the treatment of urinary tract infections and intestinal infections, as well as local antiseptics. However, low solubility in water, the possibility of undesirable reactions, as well as the absence of prolonged action significantly limit their use. It is known that the inclusion of biologically active substances in the polysaccharide molecule allows improving the already known drugs while changing their properties. Thus, the introduction of the 5-nitrofuran cycle in native alginic acid and some of its derivatives led to the emergence of antifungal activity and improved solubility. However, the information about the antimicrobial activity of N-arylidene(alkyliden)hydrazides of carboxymethylalginic acid in the literature are practically absent.Aim. Synthesis and study of antimicrobial activity of N-arylidene(alkyliden)hydrazides of carboxymethylalginic acid with different content of a biologically active fragment.Materials and methods. For the proof of the structure of the synthesized substances were used IRand UV-spectroscopy, antimicrobial activity was analyzed by double serial dilution on the test-cultures Staphylococcus aureus, Escherichia coli and Candida albicans.Results and discussion. With the introduction of 5-nitrofurfural and β-(5-nitro-2-furyl)-acrolein into the carboxymethylalginic acid, samples with antimicrobial activity were obtained, whose spectrum of action differs from furacilin. Thus, in the polymer acylhydrazones β-(5-nitro-2-furyl)-acrolein of alginic acid, a high antifungal action against C. albicans was found, the fungistatic and fungicidal action reaches 1,8 and 3,6 µg/ml.Conclusion. The synthesized samples of polymer acylhydrazones 5-nitrofurfural and β-(5-nitro-2-furyl)-acrolein have antimicrobial action, and unlike furacilin are highly soluble in water and do not irritate the skin and mucous membranes. The content of 5-nitrofuran fragment, at which the maximum antimicrobial activity is achieved, is revealed.
The Method of Express Measurement of Moisture of Bulk Material During Pneumo Transport Process in the Pharmaceutical Industry, Based on the Pockels Effect (Review)
Authors: Gulyaev V. G. , Gulyaev I. V. 
Published: September 2019

Introduction. The article presents data on the development and implementation of a method for measuring the moisture content of bulk material during its pneumatic transport in pharmaceutical production. The method of measuring moisture is theoretically based on the physical Pockels effect. An analysis of the currently existing pharmacopoeial methods for monitoring the quantitative water content and methods of in-process control of the drying process is presented. The development of new methods and technical means that provide the necessary speed and accuracy of moisture measurement is an important task, especially in the pharmaceutical industry to control the residual moisture of the starting materials, intermediate products during their production and finished products.Text. Analysis of the theoretical assumptions for the method and technical systems for measuring the mass of bulk dielectric materials during their pneumatic conveying shows the ability to measure the moisture content of the bulk dielectric material transported by air through a pipeline in a new non-contact manner. The proposed method is based on one measurable parameter – the intensity of the light wave passing through the Pockels cell. A block diagram of the system developed by the authors for automated moisture measurement of bulk dielectric materials with an electrooptical Poсkels cell is presented. The article describes a method for measuring moisture, based on the Pockels effect, for bulk material during its pneumatic transport.Conclusion. The proposed method of measuring moisture is contactless, just technically feasible, has a high speed and measurement accuracy, since it is based on the Pockels effect. The method is universal for determining the moisture content of bulk dielectric materials in the process of their pneumatic transportation. The above advantages of this method suggest the possibility of its successful application in pharmaceutical production.
Comparative Analysis of Perspective Extragation Methods for Receiving Extractions from Fenugreek Seeds
Authors: Belokurov S. S. , Flisyuk E. V. , Narkevich I. A. , Luzhanin V. G. , Shilov S. V. , Novikova K. O. 
Published: September 2019

Introduction. Today, innovative technologies are widely used in pharmacology (in particular, in the production of herbal preparations), in cosmetology (obtaining various extracts and oils, complex preparations), as well as in the food industry (as natural dyes, etc.). Plant extracts with a high level of risk do not have a harmful effect on the human body, except that they provide environmental safety, which creates a special interest for the pharmaceutical industry . vibrocavitation and supercritical fluid CO2 extraction.Aim. The choice of the optimal level of extraction to obtain a high level of fenugreek seeds.Materials and methods. Obtaining a vibrocavitation extract with an experimental vibration-explosive installation made at the Department of Processes and Apparatus of the St. Petersburg State Technology Institute. Extracts at a temperature of 60±2 ºС. The frequency of revolutions of the homogenizer ranged from 1000 to 5000 rpm. Ultrasonic impact using ultrasound unit I100-6/4 Ultrasonic effect on solid plant material with an intensity of 22 kHz for 60 minutes. The time of extraction in a vibro-cavitation extractor-homogenizer was studied for optimal values.Supercritical fluid CO2-extraction is obtained in two versions with the use of extragent (96% ethanol in the presence of carbon dioxide: ethanol 9:1) and without it. Extraction of the sound of a supercritical fluid extraction system with a 1-liter vessel. SFE1000-2-BASE with a kit for upgrading the SFE1000-2-BASE system to an SFE1000M1-2-FMC50 system (Waters, USA). The flow rate of the extractant was 60 g/min. Emergency listening for one hour and pressure 200, 300 and 400 bar. Extraction is observed three times. The obtained extracts indicate the amount of extractive substances according to article of Russian state pharmacopoeia 1.5.3.0006.15 «Determination of the content of extractive substances in plant raw materials and medicinal plant preparations». Quantitative determination of the saponin complex of parasitic seed seeds on an Agilent QTOF-6530 chromatograph with two ESI and APCI ionization sources according to Gravel et al.Results and discussion. Studies have allowed to determine the amount of extractives in the seeds and choose the most promising method. Conclusion. As a result of our research, it was found that the most promising extraction method for extracting seeds is a parasitic with vibration extraction at frequent revolutions of the homogenizer of 5000 rpm and an extraction time of 60 minutes.
Development and Validation of Approach for the Detection of Neutralizing Antibodies Against Insulin (Glargine) in Human Blood Plasma
Authors: Abramenko N. A. , Vnukova P. I. , Golovina E. S. , Makarenko I. E. , Mosikian A. A. , Nikiforova A. G. , Gremyakova P. A. , Kazey V. I. 
Published: September 2019

Introduction. IImmunogenicity identification of therapeutic proteins, such as human insulin analogues, is one of the most relevant and significant area in medicine and pharmaceuticals. Determination the possibility of producing neutralizing antibodies to insulin reducing the therapeutic effect of the drug, is an important step to understand the pharmacological profile of the drug. Applying of cell-based methods one allows to determinate neutralizing antibodies to insulin.Aim. Development and validation methods for detection of neutralizing antibodies against insulin in human plasma.Materials and methods. The method is based on the use of the iLiteTM Insulin Assay Ready Cells [1], in the genome of which the firefly luciferase reporter gene is introduced under the control of an insulin-dependent promoter. As the insulin concentration increases, the firefly luciferase expression (Firefly) increases, allowing one to use this cell line to estimate the number of neutralizing antibodies against insulin. For normalization by the number of cells and considering the matrix effect of studied samples, the second reporter gene luciferase Renilla is used, which is expressed under the control of a constitutive promoter. The activity of both luciferases was measured using the DualGlo Luciferase Assay System (Promega) assay [2].Results and discussion. Optimal insulin concentration and plasma/serum dilution were determined to identify neutralizing antibodies to insulin. The long-term stability of neutralizing antibodies to insulin were shown in human plasma for more than 3 months. The developed method was applied in a comparative research of the safety and immunogenicity of insulin analogues (Glargine). Method for the determination of antibodies to insulin was.Conclusion. A method for determination of neutralizing antibodies to insulin in human K2EDTA plasma was developed and validated using iLiteTM Insulin Assay Ready Cells system; based on the binding of the insulin alpha chain to the high-affinity heterodimeric CD220 receptor.
Pengaruh Kualitas Pelayanan dan Kepuasan Pelanggan Terhadap Pembelian Ulang
Authors: Purbasari Dewi Maharani , Permatasari Dewi Laily 
Published: September 2019

Abstract. The purpose of this study is to determine the effect of service quality and customer satisfaction on repeat purchase. The research method used in this research is quantitative research method. Population in this research is consumer of Yogya Grand Cirebon, with total sample counted 100 respondents. The sampling technique used uses purposive sampling. Data collection techniques used in this study is a questionnaire, with the scale measurement instrument using Likert scale. Data analysis technique used is multiple regression. The results showed that there is a significant influence between service quality and customer satisfaction on repeat purchase, partially and simultaneously. Keywords: Service quality ; Customer satisfaction; Repeat purchase Abstrak. Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas pelayanan dan kepuasan pelanggan terhadap pembelian ulang. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Populasi dalam penelitian ini adalah konsumen Yogya Grand Cirebon, dengan jumlah sampel sebanyak 100 orang responden. Teknik penarikan sampel yang digunakan mennggunakan sampling purposive. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner, dengan skala pengukuran instrumen menggunakan skala likert. Teknik analisis data yang digunakan adalah regresi ganda. Hasil penelitian menunjukan bahwa terdapat pengaruh yang signifikan antara kualitas pelayanan dan kepuasan konsumen terhadap pembelian ulang, secara parsial dan simultan. Katakunci: Kualitas Pelayanan ; Kepuasan pelanggan; Pembelian Ulang
Analisis Faktor Yang Mempengaruhi Underpricing Pada Perusahaan Yang Terdaftar di Bursa Efek Indonesia Tahun 2010-2016
Authors: Sembiring Era Franatalia , Rahmawati Gina , Kusumawati Ferby Wijaya 
Published: September 2019

Abstract. The aim of this research is to analyze the influencing factors stock underpricing in the year of 2010-2016. This research analyzes the influence Debt to Asset Ratio (DAR), Return on Equity (ROE), and the firm size to stock underpricing. This research uses purposive sampling method so, from 155 companies of the population, there are 96 companies were selected as research samples. The test consists of a classic assumption test and statistical hypothesis test namely partial test and simultan test uses multiple regressions. The results of the research show partially, variable return on equity (ROE) take effect negatively and significant to underpricing, firm size take effect positively and significant to underpricing, but variable debt to asset ratio (DAR) there is no effect to company underpricing. Simultaneously, debt to asset ratio (DAR), return on equity (ROE), and firm size jointly have a significant effect to underpricing. For further research, is expected to add to the research period and add more research variable allows affect underpricing. Keywords: DAR, IPO, ROE , Size, Underpricing Abstrak. Penelitian ini dilakukan dengan tujuan untuk menganalisis faktor-faktor yang mempengaruhi underpricing saham pada tahun 2010-2016. Penelitian ini menganalisis pengaruh Debt to Asset Ratio (DAR), Return on Equity (ROE), dan ukuran perusahaan terhadap underpricing saham. Metode pengambilan sampel dalam penelitian ini adalah purposive sampling sehingga dari 155 perusahaan yang menjadi populasi terpilih 96 perusahaan yang dijadikan sampel penelitian. Pengujian terdiri dari uji asumsi klasik dan uji hipotesis statistik yaitu uji parsial dan uji simultan menggunakan multiple regresi. Hasil penelitian menunjukkan bahwa secara parsial variabel return on equity (ROE) berpengaruh negatif dan signifikan terhadap underpricing, ukuran perusahaan (Size) berpengaruh positif dan signifikan terhadap underpricing, sedangkan variabel debt to asset ratio (DAR) tidak berpengaruh terhadap underpricing perusahaan. Secara simultan debt to asset ratio (DAR), return on equity (ROE), dan ukuran perusahaan (size) secara bersama-sama berpengaruh signifikan terhadap underpricing. Untuk penelitian selanjutnya diharapkan untuk menambah periode penelitian dan menambah varibel penelitian yang lebih memungkinkan mempengaruhi underpricing. Kata Kunci : DAR, IPO, ROE , Size, Underpricing
8. Sınıf Türkçe Dersi Merkezî Sınav Sorularının PISA Okuma Becerileri Yeterlilikleri Açısından İncelenmesi
Authors: TUZLUKAYA Salih 
Published: September 2019

PISA araştırmasında
okuma becerileri; “kişinin topluma katılmak, potansiyelini ve bilgisini
geliştirmek ve amaçlarını gerçekleştirmek için yazılı metinleri anlaması,
kullanması, onlar üzerinde düşünmesi ve onlarla uğraşması” olarak
tanımlanmaktadır.

Bir dil ve beceri
eğitimi olan Türkçe öğretiminde öğrencilerin metni anlamaları, öğrenme sürecine
aktif olarak katılmaları, metni çözümlemeleri, eleştirel düşünme becerilerini
aktif olarak kullanabilmeleri ancak metni oluşturan tüm parçaların bütün olarak
ele alınmasıyla mümkün olacaktır. Böyle bir yaklaşımla Türkçe derslerinin
işlenmesi, öğrencilerin metni gerçekten analiz etmelerini, anlamlandırmalarını
ve metni bir bütün olarak parçalarıyla ve parçaların birbirleriyle olan
ilişkilerini kavramalarına yardımcı olacaktır. Bu veriler
doğrultusunda, yapılan son PISA araştırmasında okuma becerileri alanında ve
temel eğitimden ortaöğretime geçişte büyük bir paya sahip 8. Sınıflar Merkezi
Sınavlarda Türkçe dersindeki öğrencilerin başarısız olma nedenleri düşünüldüğünde
“okuryazarlık” becerilerinin öğrencilerde eksik olduğu görülmektedir. Bu
sebeple, MEB tarafından hazırlanan temel eğitimden ortaöğretime geçişte
uygulanan 8.Sınıf Türkçe Dersi Merkezî Sınav soruları ve soruların dayanağı
olan kazanımlar, PISA yeterliliklerine göre yeniden gözden geçirilmeli ve
yapılandırılmalıdır. Bu bağlamda 8. Sınıf Türkçe Öğretim Programı’ndaki okuma
alanı ile ilgili kazanımlarla PISA yeterlilikleri karşılaştırıldığında Türkçe
dersi kazanımlarının daha çok alt düzey becerileri gerçekleştirmeye yönelik
olduğu sonucu ortaya çıkmaktadır. O halde Türkçe dersi kazanımlarının ve
sorularının PISA okuma becerileri değerlendirme çerçevesine göre daha üst düzey
becerileri ölçebilecek niteliğe çıkarılması uygun olacaktır.﻿