bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengths‐based reading assessment for deaf and hard‐of‐hearing students
Authors: Luft Pamela 
Published: August 2019

AbstractMost standardized reading assessments used with deaf and hard‐of‐hearing (d/Dhh) students do not accommodate their frequent lack of spoken language fluency. Such tests are rarely normed on d/Dhh individuals and do not adjust for potentially biased test items. Yet, accurate and valid measures of reading skills are essential for making appropriate instructional and programmatic decisions. The miscue analysis procedure is an individualized reading assessment using an authentic reading experience with systematic procedures for evaluating a reader's meaning‐making processes. It has been used successfully with struggling, successful, bilingual, and diverse hearing readers to identify distinctive skill patterns. Its flexible and individualized procedures may lead to similar insights regarding the reading processes utilized by d/Dhh students. This manuscript describes adaptations of the reading miscue analysis for d/Dhh students who use spoken language, English‐based sign systems, or American Sign Language. Similar to running record procedures, the miscue analysis utilizes a comprehensive analytic process. In addition, each miscue is categorized across graphophonic/visual, semantic, and syntactic aspects of the reading process to identify unique meaning making patterns. This type of comprehensive and authentic assessment can lead to an improved understanding of the strengths and needs of d/Dhh students that result in improved achievement.
Protocadherin 7 is overexpressed in castration resistant prostate cancer and promotes aberrant MEK and AKT signaling
Authors: Shishodia Gauri , Koul Sweaty , Koul Hari K. 
Published: August 2019

AbstractBackgroundCastrate resistant prostate cancer (CRPC) accounts for almost all prostate cancer (PCa) deaths. Aberrant activation of ERK/MEK and PI3K/AKT signaling pathways plays an important role in subsets of patients with CRPC. The role of protocadherin 7 (PCDH7) in modulating these signaling pathways is investigated for the first time in PCa in the present investigation.MethodsPCDH7 expression was analyzed in CRPC/neuroendocrine prostate cancer (NEPC) dataset. Protein expression was assessed by Western blotting and immunohistochemistry, and messenger RNA (mRNA) by quantitative real‐time polymerase chain reaction. Small hairpin ribonucleic acid was used to knockdown PCDH7. Colony formation, cell migration, and invasion studies were done using standard protocols.ResultsPCDH7 amplification/mRNA upregulation was observed in 41% of patients in CRPC/NEPC dataset. PCDH7 was also overexpressed in CRPC cells. Increased PCDH protein expression was observed during tumor progression in PCa tissues and in TRAMP mice. Epidermal growth factor treatment resulted in aberrant activation of ERK/AKT. Knockdown of PCDH7 decreased ERK, AKT, and RB phosphorylation and reduced colony formation, decreased cell invasion, and cell migration.ConclusionsThese data show for the first time that PCDH7 is overexpressed in a large number of patients with CRPC and suggest that PCDH7 may be an attractive target in subsets of patients with CRPC for whom there is no cure to‐date.
Microwave‐Assisted Nanocatalysed Synthesis of Phenacyl Halides as Future Anti‐Platelet Agents
Authors: Jangid Dinesh K , Dhadda Surbhi , Goswami Prakash G. , Guleria Anjali , Pareek Kapil , Jangir Nidhi , Poonam  
Published: August 2019

AbstractAn efficient, environmentally benign and novel method for the synthesis of phenacyl halides as antiplatelet agents has been reported in the presence of nanocatalyst (TiO2) by using N‐halosuccinimides (NXS, X=Cl, Br) as a source of halogen and tert‐Butyl Hydrogen Peroxide (TBHP) under microwave irradiation. Compound 2a showed best in vitro antiplatelet activity with 540 and 480 sec as clotting time in prothrombin time (PT) and activated partial thromboplastin time (APTT) assay respectively. Rest compounds showed good to moderate activity. Structures of all synthesized compounds were elucidated by IR, NMR and Mass spectrometry.
Phosphonium‐Based Ionic Liquids Used as Reagents or Catalysts
Authors: Macarie Lavinia , Simulescu Vasile , Ilia Gheorghe 
Published: August 2019

AbstractThe role and enlarged importance of ionic liquids (ILs) in chemical reactions were already exhaustively demonstrated. The aim of this review is to promote the family of the phosphonium‐based ILs used as reagents and catalysts, which gained increased interest in the last decade. The common and beneficial properties of ILs refer to their negligible vapour pressure, non‐toxicity, reusability, and high thermal stability. Therefore, phosphonium‐based ionic liquids are used successfully as catalysts and reagents in many chemical reactions, and additionally allow the syntheses in mild reaction conditions. Phosphonium ILs have proved their catalytic efficiency in many reactions such as epoxidation of olefins and allylic alcohol, in synthesis of alpha‐aminophosphonates, beta‐ketophosphonates, nitrogen‐containing bisphosphonates, the Michaelis‐Arbuzov reactions, esterification, coupling reaction, aromatic chlorination, dehydrogenation. The major advantage of phosphonium‐based ILs used as catalysts is that they can be reused with only little loss of catalytic activity. Phosphonium ILs revealed their potential as Wittig reagents, halogenation reagents for bromination and bromo‐chlorination reactions with alkenes and alkynes, as monomer and as initiator in frontal polymerization of acrylates. From the literature data, it can be concluded that due to their structure and physical‐chemical properties phosphonium ILs can be tailored function of their purpose.
Controlled Production of Monodisperse Plant‐Mediated AgNP Catalysts Using Microwave Chemistry: A Desirability‐Function‐Based Multiple‐Response Optimization Approach
Authors: Ertürk Ali Serol 
Published: August 2019

AbstractThis study introduces a new straightforward strategy for screening the formation of catalytically active and monodisperse silver nanoparticles (AgNPs) using Epilobium parviflorum green tea extract and microwave technology. The method facilitates from multivariate statistical analysis for the optimization of the reaction conditions at which the produced AgNPs exhibit the best catalytic response for the model reduction reaction of 4‐nitrophenol (4‐NP). A five‐level two‐factor Central Composite (CCD) design of experiments (DOE) together with a response surface methodology (RSM) based desirability function approach was applied for the optimization of two variables, which are microwave exposure time and amount of silver nitrate, to obtain the desired monodisperse AgNPs displaying the best catalytic activity with the green and biogenic synthesis methods. The overall desirability of 82.2% for the measure of dispersity function of AgNPs (
) and the first‐order‐reaction rate constants (
) were obtained. The nanospheres with the TEM mean diameter of 19.10±2.06 nm were successfully synthesized in the optimized conditions: 15 min of microwave exposure time and 4 mL of AgNO3 (10 mM) at 100 °C with a laboratory‐grade microwave reactor and the formed nanoparticles were fully characterized. Verification experiments
and
s−1) confirmed the validity of the predicted model
and
−1) (p<0.05).
Unraveling Structural Information of Turkevich Synthesized Plasmonic Gold–Silver Bimetallic Nanoparticles
Authors: Blommaerts Natan , Vanrompay Hans , Nuti Silvia , Lenaerts Silvia , Bals Sara , Verbruggen Sammy W. 
Published: August 2019

AbstractFor the synthesis of gold–silver bimetallic nanoparticles, the Turkevich method has been the state‐of‐the‐art method for several decades. It is presumed that this procedure results in a homogeneous alloy, although this has been debatable for many years. In this work, it is shown that neither a full alloy, nor a perfect core–shell particle is formed but rather a core–shell‐like particle with altering metal composition along the radial direction. In‐depth wet‐chemical experiments are performed in combination with advanced transmission electron microscopy, including energy‐dispersive X‐ray tomography, and finite element method modeling to support the observations. From the electron tomography results, the core–shell structure can be clearly visualized and the spatial distribution of gold and silver atoms can be quantified. Theoretical simulations are performed to demonstrate that even though UV–vis spectra show only one plasmon band, this still originates from core–shell type structures. The simulations also indicate that the core–shell morphology does not so much affect the location of the plasmon band, but mainly results in significant band broadening. Wet‐chemistry experiments provide the evidence that the synthesis pathway starts with gold enriched alloy cores, and later on in the synthesis mainly silver is incorporated to end up with a silver enriched alloy shell.
Resistant weeds were controlled by the combined use of herbicides and bioherbicides
Authors: Camargo Aline Frumi , Stefanski Fábio Spitza , Scapini Thamarys , Weirich Sabrina Natalia , Ulkovski Cleiton , Carezia Carine , Bordin Eduarda Roberta , Rossetto Vanusa , Júnior Francisco Reichert , Galon Leandro , Fongaro Gislaine , Mossi Altemir José , Treichel Helen 
Published: August 2019

AbstractThe intensive and abundant use of synthetic herbicides has been questioned in recent decades due to the strong dependence and also the resistance effects that are identified in weeds. Several grain crops suffer from the weed control system because many of the weeds are already resistant to the main herbicides that are used. In recent years, there has been a large gap in the market without the addition of new synthetic herbicides with mechanisms of action that differ from those already existing. The objective of this short piece is to address and overcome this challenge and bring an innovative and alternative solution that proposes a synergistic action system between bioherbicides produced by the fungus Trichoderma koningiopsis and synthetic herbicides (2,4‐dichlorophenoxyacetic acid, glyphosate, and ammonium glufosinate). The plants included in this study were Bidens pilosa (amor seco, or in the United States, beggar ticks or Spanish needle), Euphorbia heterophylla (adeus‐brasil), and Conyza bonariensis (margaridinha‐do‐campo, or, in the United States, hairy fleabane or asthmaweed). It was verified that, in the application of the biocomposites in the presence of chemical herbicides, potentiation of the phytotoxic action (100%) occurred under the target plants, emphasizing phytotoxicity to the weed, C. bonariensis, which is currently resistant to available herbicides. The bioherbicides studied have promising characteristics to be explored in the biocontrol of weeds.
Innovativeness of railway transport in the context of the development of tourism in Poland
Authors: Kozłowski Maciej , Pawełczyk Marek , Piotrowska-Piątek Agnieszka 
Published: August 2019

Abstract
The article discusses the issue of innovation activities of companies in railway transport in Poland in the context of the development of tourism. Transport infrastructure and organization, along with economic, social, ecological and political factors, are the basic stimulators for the development of tourism. In literature on the subject, this problem is rarely discussed. This article is of a review and research nature. The aim of it is to consider the condition of innovativeness of railway transport companies in Poland in the context of its role in the development of tourism in Poland. To attain the goals of this research, a critical analysis of literature on the subject and desk research have been carried out, the latter drawing on the unpublished data of Statistics Poland, referring to Polish companies from section Transportation and storage, class Passenger rail transport, interurban (according to NACE rev.2). The data derive from the three latest editions of the Community Innovation Survey (CIS). In the article, there was used data concerning: innovation activity, types of innovation, co-operation during innovative activity, importance of the source of information for innovation activity, importance of the reasons and barriers to not innovate. The data analysis reveals a rather low level of innovativeness of railway transport companies in Poland. In the authors’ opinion, this state of affairs is connected with historical and political factors: the structure and failed reforms in this sector and granting development priority to other branches of transport during the structural transformation in Poland.
On the Deformation of Dendrites During Directional Solidification of a Nickel-Based Superalloy
Authors: Aveson J. W. , Reinhart G. , Goddard C. J. L. , Nguyen-Thi H. , Mangelinck-Noël N. , Tandjaoui A. , Davenport J. R. , Warnken N. , di Gioacchino F. , Lafford T. A. , D’Souza N. , Billia B. , Stone H. J. 
Published: August 2019

Abstract
Synchrotron X-ray imaging has been used to examine in situ the deformation of dendrites that takes place during the solidification of a nickel-based superalloy. By combining absorption and diffraction contrast imaging, deformation events could be classified by their localization and permanence. In particular, a deformation mechanism arising from thermal contraction in a temperature gradient was elucidated through digital image correlation. It was concluded that this mechanism may explain the small misorientations typically observed in single crystal castings.
Volatile oil well test analysis: application of two-phase pseudo-pressure approach
Authors: Baniasadi Hamid , Rashidi Fariborz 
Published: August 2019

AbstractThis study investigates flow behavior in the volatile oil reservoirs with two‐phase flow around the wellbore and the application of two-phase pseudo-pressure function for well test analysis in such volatile oil reservoirs. To this end, flow behavior and saturation profile of the volatile oil reservoirs with flowing bottom-hole pressure below the bubble point pressure are investigated using a synthetic reservoir model. Subsequently, well test behavior of this reservoir in drawdown and buildup tests are examined. Finally, the application of two-phase pseudo‐pressure concept is examined for analyzing well test data of the volatile oil reservoir. It is shown that two-phase flow near the wellbore causes a composite behavior in well test data with decreasing mobility during drawdowns and increasing mobility during buildups. Moreover, employing normalized two-phase pseudo-pressure function introduced in this study is found to be a suitable method for well test analysis in volatile oil reservoirs. Using the aforementioned method, effective permeability and wellbore skin are estimated by eliminating the effect of gas saturation on the well test results.
Niche differentiation among annually recurrent coastal Marine Group II Euryarchaeota
Authors: Orellana Luis H , Francis T Ben , Krüger Karen , Teeling Hanno , Müller Marie-Caroline , Fuchs Bernhard M , Konstantinidis Konstantinos T , Amann Rudolf I 
Published: August 2019

Abstract
Since the discovery of archaeoplankton in 1992, the euryarchaeotal Marine Group II (MGII) remains uncultured and less understood than other planktonic archaea. We characterized the seasonal dynamics of MGII populations in the southern North Sea on a genomic and microscopic level over the course of four years. We recovered 34 metagenome-assembled genomes (MAGs) of MGIIa and MGIIb that corroborated proteorhodopsin-based photoheterotrophic lifestyles. However, MGIIa and MGIIb MAG genome sizes differed considerably (~1.9 vs. ~1.4 Mbp), as did their transporter, peptidase, flagella and sulfate assimilation gene repertoires. MGIIb populations were characteristic of winter samples, whereas MGIIa accounted for up to 23% of the community at the beginning of summer. Both clades consisted of annually recurring, sequence-discrete populations with low intra-population sequence diversity. Oligotyping of filtered cell-size fractions and microscopy consistently suggested that MGII cells were predominantly free-living. Cells were coccoid and ~0.7 µm in diameter, likely resulting in grazing avoidance. Based on multiple lines of evidence, we propose distinct niche adaptations of MGIIa and MGIIb Euryarchaeota populations that are characteristic of summer and winter conditions in the coastal North Sea.
Carbon dioxide electroreduction to C2 products over copper-cuprous oxide derived from electrosynthesized copper complex
Authors: Zhu Qinggong , Sun Xiaofu , Yang Dexin , Ma Jun , Kang Xinchen , Zheng Lirong , Zhang Jing , Wu Zhonghua , Han Buxing 
Published: August 2019

AbstractEfficient electroreduction of carbon dioxide to multicarbon products in aqueous solution is of great importance and challenging. Unfortunately, the low efficiency of the production of C2 products limits implementation at scale. Here, we report reduction of carbon dioxide to C2 products (acetic acid and ethanol) over a 3D dendritic copper-cuprous oxide composite fabricated by in situ reduction of an electrodeposited copper complex. In potassium chloride aqueous electrolyte, the applied potential was as low as −0.4 V vs reversible hydrogen electrode, the overpotential is only 0.53 V (for acetic acid) and 0.48 V (for ethanol) with high C2 Faradaic efficiency of 80% and a current density of 11.5 mA cm−2. The outstanding performance of the electrode for producing the C2 products results mainly from near zero contacting resistance between the electrocatalysts and copper substrate, abundant exposed active sites in the 3D dendritic structure and suitable copper(I)/copper(0) ratio of the electrocatalysts.
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences
Authors: Libis Vincent , Antonovsky Niv , Zhang Mengyin , Shang Zhuo , Montiel Daniel , Maniko Jeffrey , Ternei Melinda A. , Calle Paula Y. , Lemetre Christophe , Owen Jeremy G. , Brady Sean F. 
Published: August 2019

AbstractSequencing of DNA extracted from environmental samples can provide key insights into the biosynthetic potential of uncultured bacteria. However, the high complexity of soil metagenomes, which can contain thousands of bacterial species per gram of soil, imposes significant challenges to explore secondary metabolites potentially produced by rare members of the soil microbiome. Here, we develop a targeted sequencing workflow termed CONKAT-seq (co-occurrence network analysis of targeted sequences) that detects physically clustered biosynthetic domains, a hallmark of bacterial secondary metabolism. Following targeted amplification of conserved biosynthetic domains in a highly partitioned metagenomic library, CONKAT-seq evaluates amplicon co-occurrence patterns across library subpools to identify chromosomally clustered domains. We show that a single soil sample can contain more than a thousand uncharacterized biosynthetic gene clusters, most of which originate from low frequency genomes which are practically inaccessible through untargeted sequencing. CONKAT-seq allows scalable exploration of largely untapped biosynthetic diversity across multiple soils, and can guide the discovery of novel secondary metabolites from rare members of the soil microbiome.
Inducers of settlement and metamorphosis of the shrimp Hippolyte inermis Leach in Posidonia oceanica
Authors: Zupo Valerio , Mutalipassi Mirko , Glaviano Francesca , Buono Anna Cecilia , Cannavacciuolo Antonio , Fink Patrick 
Published: August 2019

AbstractLarvae of the caridean shrimp Hippolyte inermis persist in the plankton of the Mediterranean up to about one month. Since they need to reach appropriate coastal areas for their recruitment in seagrass meadows, we hypothesized that leaves of Posidonia oceanica or, alternatively, algae present in their epiphytic biofilms, might be physically recognised as target substrates and trigger larval metamorphosis and settlement. Chemical cues could improve the finding of suitable habitats for settlement. Thus, the effects of leaves of P. oceanica and biofilms of the diatom Cocconeis scutellum parva, seasonally abundant in the leaf epiphytic stratum, were investigated along with the effect of volatile organic compounds (VOCs) extracted from the epiphytic diatom. The physical induction with P. oceanica accelerated larval settlement, stimulating an earlier and faster metamorphosis of larvae. C. scutellum parva produced a weaker effect on settlement; however, diatom’s VOCs had evident influence and accelerated metamorphosis and settlement. We concluded that such chemical cues as the VOCs produced by epiphytic diatoms, reinforce the effect of physical cues for the identification of suitable settlement locations for this shrimp.
fMRI indicates cortical activation through TRPV1 modulation during acute gouty attacks
Authors: Chen Chiao-Chi , Chang Chen , Hsu Yi-Hua , Peng Yi-Jen , Lee Herng-Sheng , Huang Guo-Shu 
Published: August 2019

AbstractGout is one of the most painful disease conditions. The central mechanism of pain processing in this condition remains elusive. Cerebral blood volume (CBV) responses are faithful correlates of brain activity changes; the application of CBV-weighted functional magnetic resonance imaging (fMRI) may shed light on the issue of interest. Transient receptor potential vanilloid 1 (TRPV1) is a critical ion channel expressed both peripherally in nociceptors and centrally in the brain. Whether TRPV1 plays a critical role in gout pain was also explored. Results showed that, in rats with gouty arthritis, noxious stimulation induced CBV increases in the primary somatosensory cortex and thalamus. These increases were correlated with up-regulated TRPV1 protein expression and pain behavior. Selective blockage of central TRPV1 channel activity by intrathecal administration of AMG9810 reversed the induced pain, and abolished the induced CBV increase in thalamocortical regions. The findings support that TRPV1 activation in the central pain pathway is crucial to the augmentation of pain in gouty conditions. This new information supports the development of TRPV1-based drugs for treating gout pain, while fMRI can be useful for repeated evaluation of brain activity changes induced by gout.
Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes
Authors: Elfawal Mostafa A. , Savinov Sergey N. , Aroian Raffi V. 
Published: August 2019

AbstractSoil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids, are extremely common parasites, infecting 1–2 billion of the poorest people worldwide. Two benzimidazoles, albendazole and mebendazole, are currently used in STN mass drug administration, with many instances of low/reduced activity reported. New drugs against STNs are urgently needed. We tested various models for STN drug screening with the aim of identifying the most effective tactics for the discovery of potent, safe and broad-spectrum agents. We screened a 1280-compound library of approved drugs to completion against late larval/adult stages and egg/larval stages of both the human hookworm parasite Ancylostoma ceylanicum and the free-living nematode Caenorhabditis elegans, which is often used as a surrogate for STNs in screens. The quality of positives was further evaluated based on cheminformatics/data mining analyses and activity against evolutionarily distant Trichuris muris whipworm adults. From these data, two pairs of positives, sulconazole/econazole and pararosaniline/cetylpyridinium, predicted to target nematode CYP-450 and HSP-90 respectively, were prioritized for in vivo evaluation against A. ceylanicum infections in hamsters. One of these positives, pararosaniline, showed a significant impact on hookworm fecundity in vivo. Taken together, our results suggest that anthelmintic screening with A. ceylanicum larval stages is superior to C. elegans based on both reduced false negative rate and superior overall quality of actives. Our results also highlight two potentially important targets for the discovery of broad-spectrum human STN drugs.