bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding the signal in the Noise of Citizen Science Observations
Authors: Kelling Steve , Johnston Alison , Fink Daniel , Ruiz-Gutierrez Viviana , Bonney Rick , Bonn Aletta , Fernandez Miguel , Hochachka Wesley M. , Julliard Romain , Kraemer Roland , Guralnick Robert 
Published: May 2018

AbstractWhile many observations of species are being collected by citizen science projects worldwide, it can be challenging to identify projects collecting data that effectively monitor biodiversity. Over the past several years the allure of taking a “Big Data” approach has provided the opportunity to gather massive quantities of observations via the Internet, too often with insufficient information to describe how the observations were made. Information about species populations — where and when they occur and how many of them are there — (i.e., the signal) can be lost because insufficient information is gathered to account for the inherent biases in data collection (i.e., the noise). Here we suggest that citizen science projects that have succeeded in motivating large numbers of participants, must consider factors that influence the ecological process that affect species populations as well as the observation process that determines how observations are made. Those citizen science projects that collect sufficient contextual information describing the observation process can be used to generate increasingly accurate information about the distribution and abundance of organisms. We illustrate this using eBird as a case study, describing how this citizen science platform is able to collect vital contextual information on the observation process while maintaining a broad global constituency of participants. We highlight how eBird provides information with which to generate biodiversity indicators — specifically distribution, abundance, and habitat associations — across the entire annual cycle, even for populations of long distance migratory birds, a highly challenging taxon.
A study of parent–adolescent interaction
Authors: Kim Chankon , Lee Hanjoon , Han Sang-Lin 
Published: May 2018

Purpose
The purpose of this study is to examine the impact of family communication patterns (FCP) on adolescents’ choice of influence strategies and parents’ choice of response strategies in situations of parent–child purchase decision disagreement.

Design/methodology/approach
This study uses family triadic (mother–father–child) survey data collected from 294 Korean families. The study develops classifications of adolescent influence strategies and parental response strategies in the initial stage and subsequently investigates the impact of FCP on the adolescent child’s use of influence strategies and each parent’s use of response strategies. The final stage of the study involved an exploratory investigation aimed at discovering the adolescent influence strategies and parental response strategies that are likely used in conjunction.

Findings
Results show an overall significant impact of FCP on both adolescents’ use of influence strategies and parents’ use of response strategies. They further reveal that Korean mothers tended to encounter their children’s persistent influence attempts with unyielding, strict response strategies. The types of response strategies used by Korean fathers were not linked to particular types of influence strategies used by their children but linked to their level of education attained and household income.

Practical implications
Findings of this study may help marketers formulate an appropriate marketing communication strategy that can be effective in resolving parent–child purchase disagreement.

Originality/value
With its focus on the adolescent influence strategies, parental response strategies, and FCP as a factor influencing the strategy choice by adolescents and parents, this study provides new insights into the parent–child interaction taking place in situations of parent–child disagreement about a purchase decision.
Digital dividends in the phase of falling productivity growth and implications for policy making
Authors: Shahiduzzaman Md. , Kowalkiewicz Marek , Barrett Rowena 
Published: May 2018

Purpose
Despite the rapid pace of digitalization, aggregate productivity growth rates in most advanced countries have slowed down consistently in recent years. It creates a “puzzle”, as investment in information technology (IT) has often been thought of as a remedy to solve productivity problems. The purpose of this paper is to examine the “puzzle” by using industry-level data.

Design/methodology/approach
This research uses industry-level longitudinal data and examines changes in both labour and multifactor productivity (MFP) in Australian industries. This study uses an instrumental variable (IV) approach to estimate the models.

Findings
Findings suggest an improvement in IT-led productivity performance in recent years. Industries with an above-average share of IT (IT investment as a share of total investment) have experienced MFP boosts since 2005.

Research limitations/implications
Because of the aggregate nature of the data it was not possible to incorporate firm-specific factors, such as managerial and organisational factors, in the analysis.

Practical implications
The performance of IT has improved despite the falling growth in technology investment in recent years, suggesting that intangible factors, such as better regulatory and policy frameworks, have potentially played a positive role.

Originality/value
There are only a few studies using sectoral and longitudinal-type data, with many having become dated, meaning that there is a lack of understanding surrounding recent developments.
Longitudinal research into the effects of the high performance organisation framework
Authors: de Waal André , de Haas Jeroen 
Published: May 2018

Purpose
Many models for designing a high-performance organization (HPO) have been proposed in the past decades. However, not much information can be found in the extant literature on whether these models actually improve the results of an organization over time in a sustainable manner. The purpose of this paper is to evaluate whether de Waal’s (2012) HPO framework does help organizations increase their performance in a sustainable manner.

Design/methodology/approach
De Waal’s HPO framework was applied at Nader & Ebrahim S/O Hassan (NEH), a Philippine banana producer and exporter. In 2013, a first HPO diagnosis was conducted, in which the HPO status and possible improvements were identified. This application entailed conducting a questionnaire, holding interviews, and organizing a feedback workshop with management and employees. The aim was to identify possible improvements which the organization could implement in order to achieve high performance. Subsequently, NEH started to work on these improvements, and in 2015, a second diagnosis followed.

Findings
The second HPO diagnosis showed that both NEH’s HPO scores and organizational results had gone up considerably. The research results also showed which of the interventions, which NEH applied during working on the improvements, were most effective.

Originality/value
Virtually all of the HPO frameworks and models described in the literature have not been tested scientifically on their effectiveness. Thus, the research into the workings and effectiveness of de Waal’s framework belongs to an exclusive and limited set of longitudinal research studies which actually brings the study of effective performance models further.
The dilemma of institutional duality and multinational firms 1967-2017
Authors: Ahworegba Akiebe Humphrey 
Published: May 2018

PurposeThe purpose of this paper is to improve the understanding of the dilemma of institutional duality (ID) confronting multinational corporations and to propose a workable solution for this problem.Design/methodology/approachThe author has searched the literature using several terms directly related to the dilemma of ID and multinational firms.FindingsThe findings reveal that to attain “legitimacy”, subsidiaries strive to balance institutional pressures stemming from external environments in the host country and their parent organizations. Understanding institutional theories of multinational corporations enables the subsidiaries to manage external pressures. ID impact varies among subsidiaries, depending on institutional contexts and internal strategies of subsidiaries.Originality/valueAn “institutional duality incidence model” portraying how dual institutions make “legitimacy” problematic for subsidiaries is proposed. A framework for identifying factors generating ID dilemma and their management approach is also proposed. It is concluded that a multinational corporation that recognizes ID as a central concern is more likely to achieve and maintain a higher level of harmony with its subsidiaries and host countries.
High spatial and temporal resolution film thickness planar sensor: comparison of geometries
Authors: Bonilla Riaño Adriana , Velasco Peña Hugo Fernando , Hernandez Rodriguez Oscar Mauricio , Bannwart Antonio Carlos 
Published: May 2018

Purpose
The purpose of this paper is to study planar sensor geometries for the measurement of film thickness in a viscous oil–water flow. The study is relevant due to there are only a few measurement techniques for oil-water flow and these techniques involve oil with low viscosity (close to the water viscosity). Specifically, some techniques have been used in the studies of annular flow (gas–liquid and liquid–liquid flows), but applications in other flow patterns were not encountered.

Design/methodology/approach
Different sensor geometries were numerically simulated to compare their characteristics and choose the best to measure the water film thickness in the oil–water flow through an impedance-based technique. Finite element method was used for resolving the tridimensional electric field over each sensor. The compared characteristics were the penetration depth, the sensitivity, the minimum spatial resolution (high spatial resolution) and the quasi-linear curve.

Findings
The best geometry tested has a spatial resolution of 2 × 2 mm, a penetration depth of 700 µm and a quasi-linear response in the measuring range. This geometry was tested by means of conductance and capacitance static experiments. From these experiments, it could be determined that conductance and the capacitance systems are promising for measuring water film thickness in an oil–water flow.

Originality/value
Several measurement techniques such as micro-PIV, planar laser-induced fluorescence and planar conductive or capacitive sensors that are supposed to be adaptable to the liquid–liquid flow have been proposed recently. Micro-PIV and planar-induced fluorescence need transparent pipes and fluids. On the other hand, conductive or capacitive methods have been only applied to low viscosity fluids. In that context, this paper proposes to study a new technique for non-intrusive measurement of the liquid-liquid flow. The main goal is the validation of the new planar sensor as a reference tool for the development of instrumentation for oilfield application.
Explaining the diversity of antipassives: Formal grammar vs. (diachronic) typology
Authors: Sansò Andrea 
Published: May 2018

AbstractAntipassives have different structural and semantic properties and are used under different conditions across languages. They also show a few universal tendencies: For instance, they generally correlate with imperfectivity. Both the diversity and the universal tendencies of antipassives have fostered a variety of analyses of this construction type in the formalist and the functional typological frameworks. In this article, these analyses will be surveyed with a view to establishing their explanatory potential and will be compared with a diachronic typological account of how antipassives diverge and what they have in common. It will be shown that at least part of this diversity finds a straightforward explanation once the sources of the antipassive are taken into account and that most of the semantic and distributional universals of antipassives are persistent features of their sources.
Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration
Authors: Johnston Nikki , Dettmar Peter W. , Ondrey Frank G. , Nanchal Rahul , Lee Sang‐Hyuk , Bock Jonathan M. 
Published: May 2018

AbstractExtra‐esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but realization of the role of nonacid reflux has resulted in research investigating the use of pepsin as a biomarker for gastric reflux and aspiration. Pepsin analysis can complement the use of questionnaires and office‐based diagnosis and lessen the dependency on invasive and expensive diagnostic tests. Furthermore, pepsin as a first‐line diagnostic biomarker has been shown to improve the accuracy of reflux diagnosis. In addition to its use as a diagnostic biomarker, pepsin has been shown to cause inflammation independent of the pH of the refluxate and thus despite acid suppression therapy. Research is ongoing to develop new therapies for airway reflux that specifically target pepsin.
The Limits of Partisanship: Federalism, the Role of Bureaucrats, and the Path to Universal Health Care Coverage in Brazil
Authors: Segatto Catarina Ianni , Béland Daniel 
Published: May 2018

Scholars have argued that partisanship is the main driving force behind universal social policy, including universal health coverage. This article contributes to this debate by analyzing the Brazilian path to universal health coverage in light of this international social policy literature. The empirical research it features is grounded in the systematization of the literature and the analysis of documents and in‐depth interviews. The analysis shows that the historical and institutional path of federalism, as it intersects with the role of bureaucrats, largely account for the universalization of health care coverage in Brazil. This analysis contributes to the study of social policy universalization by stressing both the limits of partisanship as an explanatory factor and the need to take into account the institutional dynamics of federalism as it interacts with the involvement of bureaucrats in the politics of universality.Related ArticlesBernick,Ethan M., andNathanMyers.2012. “.”Politics & Policy40():131‐159.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2011.00340.x/fullLamb,Charles M., andEric M.Wilk.2009. “.”Politics & Policy37():127‐149.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2008.00164.x/abstractPalley,Howard A.2009. “.”Politics & Policy37():1074‐1077.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2009.00211.x/abstractRelated Media.2013. “Maps and Video Discussion” (in Portuguese).https://saudeamanha.fiocruz.br.2017. “Tracking Universal Health Coverage: 2017 Global Monitoring Report.”http://www.who.int/healthinfo/universal_health_coverage/report/2017/en/
Evaluation of Telavancin Alone and Combined with Ceftaroline or Rifampin against Methicillin-Resistant Staphylococcus aureus in an
In Vitro
Biofilm Model
Authors: Jahanbakhsh Seyedehameneh , Singh Nivedita B. , Yim Juwon , Rose Warren E. , Rybak Michael J. 
Published: May 2018

ABSTRACT

Infections caused by biofilm-producing methicillin-resistant
Staphylococcus aureus
(MRSA) bacteria are challenging due to increasing antibiotic resistance. Synergistic activities of lipopeptides and lipoglycopeptides with β-lactams have been demonstrated for MRSA, but little is known about biofilm-embedded organisms. Our objective was to evaluate two telavancin (TLV) dosage regimens (7.5 mg/kg of body weight and 10 mg/kg every 24 h [q24h]) alone and in combination with ceftaroline (CPT) (600 mg every 8 h [q8h]) or rifampin (RIF) (450 mg every 12 h [q12h]) against two biofilm-producing MRSA strains (494 and N315). Pharmacokinetic/pharmacodynamic CDC biofilm reactor models with polyurethane coupons were used to evaluate the efficacies of the antibiotic combinations over 72 h. Overall, there were no significant differences observed between the two TLV dosing regimens either alone or in combination with RIF or CPT against these strains. Both TLV dosing regimens and CPT alone demonstrated killing but did not reach bactericidal reduction at 72 h. However, both TLV regimens in combination with RIF demonstrated enhanced activity against both strains, with a rapid decrease in CFU/ml at 4 h that was bactericidal and maintained over the 72-h experiment (−Δ3.75 log
10
CFU/ml from baseline;
P
< 0.0001). Of interest, no enhanced activity was observed for TLV combined with CPT. No development of resistance was observed in any of the combination models. However, resistance to RIF developed as early as 24 h, with MIC values exceeding 32 mg/liter. Our results show that TLV plus RIF displayed therapeutic improvement against biofilm-producing MRSA. These results suggest that TLV at 7.5 and 10 mg/kg q24h are equally effective in eradicating biofilm-associated MRSA strains
in vitro
.
Lack of tone in mouse small mesenteric arteries leads to outward remodeling, which can be prevented by prolonged agonist-induced vasoconstriction
Authors: Klein Anika , Joseph Philomeena Daphne , Christensen Vibeke Grøsfjeld , Jensen Lars Jørn , Jacobsen Jens Christian Brings 
Published: May 2018

Inward remodeling of resistance vessels is an independent risk factor for cardiovascular events. Thus far, the remodeling process remains incompletely elucidated, but the activation level of the vascular smooth muscle cell appears to play a central role. Accordingly, previous data have suggested that an antagonistic and supposedly beneficial response, outward remodeling, may follow prolonged vasodilatation. The present study aimed to determine whether 1) outward remodeling follows 3 days of vessel culture without tone, 2) a similar response can be elicited in a much shorter 4-h timeframe, and, finally, 3) whether a 4-h response can be prevented or reversed by the presence of vasoconstrictors in the medium. Cannulated mouse small mesenteric arteries were organocultured for 3 days in the absence of tone, leading to outward remodeling that continued throughout the culture period. In more acute experiments in which cannulated small mesenteric arteries were maintained in physiological saline without tone for 4 h, we detected a similar outward remodeling that proceeded at a rate several times faster. In the 4-h experimental setting, continuous vasoconstriction to ~50% tone by abluminal application of UTP or norepinephrine + neuropeptide Y prevented outward remodeling but did not cause inward remodeling. Computational modeling was used to simulate and interpret these findings and to derive time constants of the remodeling processes. It is suggested that depriving resistance arteries of activation will lead to eutrophic outward remodeling, which can be prevented by vascular smooth muscle cell activation induced by prolonged vasoconstrictor exposure. NEW & NOTEWORTHY We have established an effective 4-h method for studying outward remodeling in pressurized mouse resistance vessels ex vivo and have determined conditions that block the remodeling response. This allows for investigating the subtle but clinically highly relevant phenomenon of outward remodeling while avoiding both laborious 3-day organoid culture of cannulated vessels and in vivo experiments lasting several weeks.
Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations
Authors: Park Song-Yi , Freedman Neal D. , Haiman Christopher A. , Le Marchand Loïc , Wilkens Lynne R. , Setiawan Veronica Wendy 
Published: May 2018

Abstract
Background: Coffee intake has been associated with risk of various cancers, but the findings, mostly from studies in white populations, are inconsistent. We examined the association of coffee consumption with overall cancer incidence and specific cancer sites in a large prospective study of African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites.
Methods: 167,720 participants of the Multiethnic Cohort Study in Hawaii and Los Angeles were included. Baseline coffee intake was assessed by a validated food-frequency questionnaire. HRs and 95% confidence intervals (CIs) for sixteen cancers associated with coffee intake were calculated using Cox regressions.
Results: During a mean follow-up of 15.3 years, 34,031 incident cancer cases were identified among study participants. Coffee intake was associated inversely with liver (≥4 cups/day vs. none: HR = 0.57; 95% CI, 0.38–0.87; Ptrend &lt; 0.001), ovarian (HR = 0.33; 95% CI, 0.17–0.65; Ptrend = 0.007), and thyroid (HR = 0.44; 95% CI, 0.23–0.87; Ptrend = 0.007) cancers and melanoma (HR = 0.72; 95% CI, 0.52–0.99; Ptrend = 0.002). Coffee intake was also inversely associated with endometrial cancer among women with a body mass index &gt;30 kg/m2 (HR = 0.31; 95% CI, 0.14–0.72; Ptrend = 0.04). The associations were similar across five ethnic groups (Pheterogeneity &gt; 0.06) and were mainly observed among those who drank caffeinated coffee.
Conclusions: On the basis of our prospective data in diverse populations, we found a decreased risk of liver, ovarian, thyroid, and endometrial cancers and melanoma associated with higher coffee intake.
Impact: These results suggest that coffee drinking may protect against liver, ovarian, thyroid, and endometrial cancers, and melanoma. Cancer Epidemiol Biomarkers Prev; 27(8); 928–35. ©2018 AACR.
A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease
Authors: Seliger Stephen L. , Abebe Kaleab Z. , Hallows Kenneth R. , Miskulin Dana C. , Perrone Ronald D. , Watnick Terry , Bae Kyongtae Tae 
Published: May 2018

<b><i>Background:</i></b> Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD). <b><i>Methods:</i></b> A phase II, double-blinded randomized placebo-controlled trial of 26 months duration. Participants will include nondiabetic adults (<i>n</i> = 96) aged 18–60 years, with an estimated glomerular filtration rate (eGFR) ≥50 mL/min/1.73 m<sup>2</sup> and ADPKD, recruited from university-based practices in Baltimore and Boston. Participants will be randomized in 1: 1 ratio to metformin or placebo at 500 mg once daily, increased every 2 weeks to a maximum of 1,000 mg twice daily as tolerated. Dose is decreased if eGFR falls to 30–45 mL/min/1.73 m<sup>2</sup> and discontinued at eGFR &#x3c; 30 mL/min/1.73 m<sup>2</sup>. <b><i>Results:</i></b> The primary outcomes are safety, assessed by the rates of hypoglycemia, elevated lactic acid levels, adverse events, and tolerability assessed by the Gastrointestinal Severity Rating Scale and maximum tolerated dose of study medication. Secondary outcomes include changes in total kidney and liver volumes, pain, and health-related quality of life, and changes in urinary metabolomic biomarkers. <b><i>Conclusions:</i></b> Results of this trial will provide important information on the feasibility, safety, and tolerability of long-term use of metformin in patients with ­ADPKD and provide preliminary information regarding its efficacy in slowing disease progression. Furthermore, results may support or refute the hypothesis that metformin effects on disease progression are mediated through the activation of the AMPK pathway. These results will be essential for the justification and design of a full-scale efficacy trial.