bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin
Authors: Ni Fan , Huang Xianbo , Chen Zhenzhen , Qian Wenbin , Tong Xiangmin 
Published: February 2018

AbstractBurkitt’s lymphoma (BL) is a highly aggressive malignancy molecularly characterized by deregulation of the C-MYC proto-oncogene. Recently, it has been confirmed that phosphatidylinositol-3-kinase (PI3K) pathway activation is a crucial element in the malignant transformation of the B cells in BL. Despite the better outcome of adults with BL treated with high-intensity chemotherapy regimens, the overall survival rate for patients older than 60 years remains dismal. Shikonin, a natural naphthoquinone derived from Chinese herbal medicine plant, has the potential to induce cell death in a series of human cancer. In the present study, we investigated the effect and molecular mechanisms of Shikonin in treatment with BL. Shikonin suppressed cellular proliferation and induced caspase-dependent apoptosis in BL cells. Inhibition of C-MYC and suppression of PI3K/AKT/mTOR pathway played critical roles in SHK-induced apoptosis in BL both in vitro and in vivo. Besides, Shikonin potentiated doxorubicin-induced growth inhibition and apoptosis in vitro. Furthermore, the growth of a subcutaneous xenograft tumor model of BL was significantly inhibited by shikonin. Importantly, we did not find the effect of shikonin on liver function in mice. In summary, these data suggest that shikonin may be an encouraging chemotherapeutic agent in the clinical treatment of BL.
Photonic Generation of Triangular-shaped Waveform Based on External Modulation
Authors: Yuan Jin , Ning Tigang , Li Jing , Pei Li , Zheng Jingjing , Li Yueqin 
Published: February 2018

AbstractWe present a novel approach for triangular-shaped waveform generation by applying optical single sideband (OSSB) modulation and optical carrier suppression (OCS) modulation to an input signal. Firstly, an OSSB modulated signal consists of an optical carrier and +1st-order sideband, is initially generated with a dual-drive Mach-Zehnder modulator (DD-MZM1) driven by a quadruple frequency RF signal. By tuning the amplitude of the RF signal and the bias of the DD-MZM1, the power ratio between the carrier and the +1st-order sideband is controlled as 19 dB. These two components are then transmitted to a DD-MZM2 which is driven by a fundamental frequency. After OCS modulation, four sidebands are existed in optical spectra of the modulated signal. By utilizing a fiber Bragg grating (FBG) to remove the undesired sideband, an output signal that features a triangular-shaped waveform is finally achieved.
fNIRS Optodes’ Location Decider (fOLD): a toolbox for probe arrangement guided by brain regions-of-interest
Authors: Zimeo Morais Guilherme Augusto , Balardin Joana Bisol , Sato João Ricardo 
Published: February 2018

AbstractThe employment of functional near-infrared spectroscopy (fNIRS) as a method of brain imaging has increased over the last few years due to its portability, low-cost and robustness to subject movement. Experiments with fNIRS are designed in the face of a limited number of sources and detectors (optodes) to be positioned on selected portion(s) of the scalp. The optodes locations represent an expectation of assessing cortical regions relevant to the experiment’s hypothesis. However, this translation process remains a challenge for fNIRS experimental design. In the present study, we propose an approach that automatically decides the location of fNIRS optodes from a set of predefined positions with the aim of maximizing the anatomical specificity to brain regions-of-interest. The implemented method is based on photon transport simulations on two head atlases. The results are compiled into the publicly available “fNIRS Optodes’ Location Decider” (fOLD). This toolbox is a first-order approach to bring the achieved advancements of parcellation methods and meta-analyses from functional magnetic resonance imaging to more precisely guide the selection of optode positions for fNIRS experiments.
Implementation Research: Embracing Practitioners' Views
Authors: Feuerstein Julie L. , Olswang Lesley B. , Greenslade Kathryn J. , Dowden Patricia , Pinder Gay Lloyd , Madden Jodi 
Published: February 2018

Purpose
This research explores practitioners' perspectives during the implementation of triadic gaze intervention (TGI), an evidence-based protocol for assessing and planning treatment targeting gaze as an early signal of intentional communication for young children with physical disabilities.

Method
Using qualitative methods, 7 practitioners from 1 early intervention center reported their perceptions about (a) early intervention for young children with physical disabilities, (b) acceptability and feasibility in the use of the TGI protocol in routine practice, and (c) feasibility of the TGI training. Qualitative data were gathered from 2 semistructured group interviews, once before and once after TGI training and implementation.

Results
Qualitative results documented the practitioners' reflections on recent changes to early intervention service delivery, the impact of such change on TGI adoption, and an overall strong enthusiasm for the TGI protocol, despite some need for adaptation.

Conclusion
These results are discussed relative to adapting the TGI protocol and training, when considering how to best bring about change in practice. More broadly, results highlighted the critical role of researcher–practitioner collaboration in implementation research and the value of qualitative data for gaining a richer understanding of practitioners' perspectives about the implementation process.
Tutorial and Guidelines on Measurement of Sound Pressure Level in Voice and Speech
Authors: Švec Jan G. , Granqvist Svante 
Published: February 2018

Purpose
Sound pressure level (SPL) measurement of voice and speech is often considered a trivial matter, but the measured levels are often reported incorrectly or incompletely, making them difficult to compare among various studies. This article aims at explaining the fundamental principles behind these measurements and providing guidelines to improve their accuracy and reproducibility.

Method
Basic information is put together from standards, technical, voice and speech literature, and practical experience of the authors and is explained for nontechnical readers.

Results
Variation of SPL with distance, sound level meters and their accuracy, frequency and time weightings, and background noise topics are reviewed. Several calibration procedures for SPL measurements are described for stand-mounted and head-mounted microphones.

Conclusions
SPL of voice and speech should be reported together with the mouth-to-microphone distance so that the levels can be related to vocal power. Sound level measurement settings (i.e., frequency weighting and time weighting/averaging) should always be specified. Classified sound level meters should be used to assure measurement accuracy. Head-mounted microphones placed at the proximity of the mouth improve signal-to-noise ratio and can be taken advantage of for voice SPL measurements when calibrated. Background noise levels should be reported besides the sound levels of voice and speech.
Nuclotron Beam Momentum Estimation Using Multiwire Proportional Chambers and Drift Chambers in the BM@N Experiment
Authors: Kapishin Mikhail , Lenivenko Vasilisa , Palichik Vladimir , Voytishin Nikolay 
Published: February 2018

The BM@N experiment is considered as the first phase of NICA Mega science project. The energy of the beam will vary from 1 to 6 GeV/u. The beams delivered by Nuclotron will be of different types from protons to Au. The ability to reconstruct the beam momentum with high precision is one way for showing that the tracking detectors are tuned in the right way and the reconstruction procedure performs well.
A quick overview of the experimental setup is given in the work along with the description of some of the main tracking detectors. The beam momentum reconstruction procedure is described and results are presented for different values of the beam energy.
Optimizing the User Experience: Identifying Opportunities to Improve Use of an Inpatient Portal
Authors: Walker Daniel , Menser Terri , Yen Po-Yin , McAlearney Ann 
Published: February 2018

Background Patient portals specifically designed for the inpatient setting have significant potential to improve patient care. However, little is known about how the users of this technology, the patients, may interact with the inpatient portals. As a result, hospitals have limited ability to design approaches that support patient use of the portal.
Objectives This study aims to evaluate the user experience associated with an inpatient portal.
Methods We used a Think-Aloud protocol to study user interactions with a commercially available inpatient portal—MyChart Bedside (MCB). Study participants included 19 English-speaking adults over the age of 18 years. In one-on-one sessions, participants narrated their experience using the MCB application and completing eight specific tasks. Recordings were transcribed and coded into three dimensions of the user experience: physical, cognitive, and sociobehavioral.
Results Our analysis of the physical experience highlighted the navigational errors and technical challenges associated with the use of MCB. We also found that issues associated with the cognitive experience included comprehension problems that spurred anxiety and uncertainty. Analysis of the sociobehavioral experience suggested that users have different learning styles and preferences for learning including self-guided, handouts, and in-person training.
Conclusion Inpatient portals may be an effective tool to improve the patient experience in the hospital. Moreover, making this technology available to inpatients may help to foster ongoing use of technology across the care continuum. However, deriving the benefits from the technology requires appropriate support. We identified multiple opportunities for hospital management to intervene. In particular, teaching patients to use the application by making a variety of instructional materials available could help to reduce several identified barriers to use. Additionally, hospitals should be prepared to manage patient anxiety and increased questioning arising from the availability of information in the inpatient portal application.
BCR-ABL Tyrosine Kinase Inhibitors: Which Mechanism(s) May Explain the Risk of Thrombosis?
Authors: Haguet Hélène , Douxfils Jonathan , Chatelain Christian , Graux Carlos , Mullier François , Dogné Jean-Michel 
Published: February 2018

AbstractImatinib, the first-in-class BCR-ABL tyrosine kinase inhibitor (TKI), had been a revolution for the treatment of chronic myeloid leukemia (CML) and had greatly enhanced patient survival. Second- (dasatinib, nilotinib, and bosutinib) and third-generation (ponatinib) TKIs have been developed to be effective against BCR-ABL mutations making imatinib less effective. However, these treatments have been associated with arterial occlusive events. This review gathers clinical data and experiments about the pathophysiology of these arterial occlusive events with BCR-ABL TKIs. Imatinib is associated with very low rates of thrombosis, suggesting a potentially protecting cardiovascular effect of this treatment in patients with BCR-ABL CML. This protective effect might be mediated by decreased platelet secretion and activation, decreased leukocyte recruitment, and anti-inflammatory or antifibrotic effects. Clinical data have guided mechanistic studies toward alteration of platelet functions and atherosclerosis development, which might be secondary to metabolism impairment. Dasatinib, nilotinib, and ponatinib affect endothelial cells and might induce atherogenesis through increased vascular permeability. Nilotinib also impairs platelet functions and induces hyperglycemia and dyslipidemia that might contribute to atherosclerosis development. Description of the pathophysiology of arterial thrombotic events is necessary to implement risk minimization strategies.
Endoscopic Endonasal Resection of Tuberculum Sellae Meningioma with Utilization of Indocyanine Green
Authors: Shahein Mostafa , Montaser Alaa , Todeschini Alexandre , Revuelta Barbero Juan , Otto Bradley , Carrau Ricardo , Prevedello Daniel 
Published: February 2018

AbstractWe present the case of a 67-year-old female with an incidental finding of a left-sided tuberculum sellae meningioma on a brain magnetic resonance imaging (MRI) for an unrelated complaint. Formal visual field testing showed a small defect in the inferior nasal and temporal fields of the left eye, compatible with mass effect on the optic nerve by the tumor.An endoscopic endonasal transtuberculum approach with decompression of the left optic nerve was performed using a standard binostril four-hand technique, with the patient positioned supine with the head turned to the right side and tilted to the left, fixed in a three-pin head clamp, under imaging guidance. After exposure, we drilled the tuberculum sellae and the floor of the sella and after opening the dura, the tumor and optic nerve came into view. The tumor was completely removed and we confirmed the patency of all perforating vessels using indocyanine green. Reconstruction was done in a multilayered fashion, using collagen matrix and a nasoseptal flap.Patient had an uneventful postoperative stay and was discharged on postoperative day 3, neurologically stable with no new hormonal deficits. Pathology report confirmed a WHO Grade I meningioma with K
i-67 of 1% and 3-month postoperative MRI confirmed a gross total resection and visual fields exam showed a complete recovery.The link to the video can be found at: https://youtu.be/zRmt2aIvX5c.
Endoscopic Endonasal Resection of a Suprasellar Pituitary Adenoma Mimicking Tuberculum Sellae Meningioma in a Patient with an Intrasellar Persistent Trigeminal Artery
Authors: Montaser Alaa , Todeschini Alexandre , Revuelta  Barbero Juan , Shahein Mostafa , Chiocca E. , Otto Bradley , Carrau Ricardo , Prevedello Daniel 
Published: February 2018

AbstractA 50-year-old female with an incidentally diagnosed suprasellar lesion was initially managed conservatively due to the presence of an intrasellar persistent trigeminal artery going through the dorsum sellae and fundamentally forming the blood supply of the entire posterior circulation. Serial follow-up brain magnetic resonance imaging (MRI) revealed progressive enlargement of the suprasellar lesion over 4 years period. Surgery was indicated after the initial tumor growth; however, the patient refused surgery for fear of complications related to the persistent trigeminal artery. Two-and-a-half years later, she presented with deterioration of vision. Formal visual field testing revealed a right temporal field defect. Brain MRI demonstrated significantly enlarged suprasellar lesion, most consistent with tuberculum sellae meningioma, exerting mass effect on the optic apparatus.The patient underwent endoscopic endonasal resection of the lesion through a transplanum/transtuberculum approach. Intraoperatively, absence of hypertrophic McConnel arteries, hyperostosis, and the fact that the dura was soft and not under tension was against the diagnosis of tuberculum sellae meningioma. Additionally, the tumor consistency was similar to a pituitary adenoma. A complete resection was accomplished and multilayer skull base reconstruction was performed with no complications. On postoperative day 1 (POD 1), she was operated upon for the evacuation of small suprasellar hematoma associated with vision deterioration. Histopathological examination confirmed the diagnosis of atypical pituitary adenoma with K
i-67 labeling index of 4 to 5%. The patient ultimately recovered well with improved vision, and was discharged on POD 4 with no new neurological deficits. At 4 years follow-up, her vision was normalized and brain MRI showed no residual or recurrent lesion.The link to the video can be found at: https://youtu.be/QZmzctjAEbw.
Functional Regions of the Medial Patellofemoral Ligament
Authors: Ji Gang , Sun Yifei , Lu Jiangfeng , Niu Yingzhen , Wang Fei 
Published: February 2018

AbstractThe purpose of this study was to explore the anatomy and discuss functional regions of the medial patellofemoral ligament (MPFL). Twelve fresh-frozen knees specimens were dissected. All medial surfaces of knees were intact and did not have indication of injury. General feature of the MPFL were observed. All anatomical landmarks were carefully identified and marked. The length of the two functional regions were conducted and recorded. All data were obtained, described, and analyzed in the form of mean ± standard deviation. The MPFL was found in all specimens we dissected. Closed to the patellar insertion, it adheres to the deep surface of the vastus medialis obliquus (VMO). Due to the VMO, the MPFL is divided into two functional regions: overlap region and nonoverlap region. Anatomically, the overlap region and nonoverlap region of 25.43 ± 2.0 and 44.85 ± 3.04 mm, the width of VMO insertion is 13.94 ± 2.03 mm, and the width of patellar insertion is 22.91 ± 3.46 mm. We divide the MPFL into two anatomical functional regions, demarcated by the meshing points of fibers between the MPFL and VMO: overlap region and nonoverlap region. This finding provides the theoretical foundation for the treatment of the MPFL injury and shed lights on the future researches.
Relationships between maximal strength of lower limb, anthropometric characteristics and fundamental explosive performance in handball players
Authors: Hermassi Souhail , Chelly Mohamed Souhaiel , Wagner Herbert , Fieseler Georg , Schulze Stephan , Delank Karl-Stefan , Shephard Roy J. , Schwesig René 
Published: February 2018

Abstract
Background The purpose of this study was to examine relationships between lower body muscular strength, anthropometric characteristics and several measures of explosive performance in elite team-handball players.
Methods 22 male elite team-handball players (age: 19.1 ± 1.7 years) were studied during the competitive season. Standard anthropometric and body composition measures included body mass index, lower limb and thigh muscle volume, and body fat percentage. Maximal leg strength was determined by a one-repetition maximum (1-RM) half back-squat. Vertical jump performance was assessed using a squat jump (SJ) and a counter movement jump (CMJ). Repeated shuttle-sprint ability (RSA) was tested by 6 (2 × 15 m) shuttle sprints with 20 s of active recovery intervals. The best time in a single shuttle sprint (30m; RSAbest), fastest total time (RSATT) and RSA test performance decrement (RSAdec) were recorded. Agility was measured using a modified T-half test (MAT). Throwing velocities of jump shooting and 3-step throwing were recorded by digital video camera.
Results The explained variance of 1-RM half-back-squats ranged from 0.2 % (RSA% Fatigue Index) to 70.1 % (CMJ). Four out of 8 variables (RSA Best Time, CMJ, SJ, throwing velocity of jump shoot) demonstrated an r2 > 0.5. Jump performances seemed closely related to 1-RM half-back-squats. Furthermore, 1-RM half-back-squats were positively correlated with leg and thigh muscle volumes (r = 0.652, r = 0.768).
Conclusion The anthropometric characteristics and some physical performance tests are closely related to the maximal strength performance of handball players. Coaches should focus on maximal strength training programs for the lower limbs when seeking improvements in the throwing velocity and jump performance of handball players.
Humans quickly learn to blink strategically in response to environmental task demands
Authors: Hoppe David , Helfmann Stefan , Rothkopf Constantin A. 
Published: February 2018

Significance
Eye blinks serve the purpose of maintaining healthy vision but during a blink visual information processing is interrupted. While a multitude of medical, cognitive, and psychological factors have been shown to influence blinking, the present study establishes quantitatively how human blinking behavior is dynamically adapted to environmental task demands. In our experiment participants quickly learned to blink strategically. A minimal computational model captures the observed behavior as a trade-off between internal, physiological benefits and external, task-related costs given perceptual uncertainties. Crucially, the model allows predicting an individual subject’s temporal dynamics of blinking and provides an explanation of the long-known distribution of interblink intervals. Taken together, this provides a basis for future research using blinking as a behavioral marker.
Twisted Lefschetz number formula and 𝑝-adic trace formula
Authors: Xiang Zhengyu 
Published: February 2018

For a reductive group

G

/

Q

G_{/\mathbb {Q}}

, we interpolate Arthurs

L
2

L^2

-Lefschetz number formula

p
p

-adically and give a geometric expansion of Urbans

p
p

-adic trace formula on overconvergent cuspidal representations. If

G

/

Q

G_{/\mathbb {Q}}

is anisotropic at infinity and

H
H

is a Weil restriction of

G
G

, we give a twisted version of Arthur’s

L
2

L^2

-Lefschetz number formula for

H
H

, and we set up both the spectral side and the geometric side of a twisted

p
p

-adic trace formula for

H
H

.
Bioeconomics of the Allee effect in fisheries targeting sedentary resources
Authors: González-Durán Enrique , Hernández-Flores Alvaro , Seijo Juan Carlos , Cuevas-Jiménez Alfonso , Moreno-Enriquez Angélica 
Published: February 2018

AbstractThe improvement of survival in some species due to the close coexistence between individuals is a concept that has caught the attention of scientists over the years. This behaviour has been documented in many taxa, including species which support commercial fisheries. In recent years, a better understanding of the mechanisms associated with the Allee effect has shown its importance in population dynamics and probably plays a more important role than previously thought. In this article, the Allee effect was analysed by means of a spatial bioeconomic model. The Allee effect component was the positive relationship between the mating probability and the density of spawners. A depensation function with an offset to the right side of the origin represented the fraction of females that mated based on density. When the model did not include the Allee effect, the fishery reached the bioeconomic equilibrium; however, when the Allee effect was considered, the fishery did not reach equilibrium, but the stock collapsed in 15 years. Fishing mortality altered the spatial distribution of the stock, causing depensation in recruits per spawner. These results may contribute to a better understanding of the Allee effect on sedentary resources and can be used to explore new models.