bluuebunny/crossref_metadata_2025_split huggingface dataset:
EPIDEMIOLOGIC AND PATHOLOGIC CHARACTERISTICS OF PATIENTS WITH ESOPHAGEAL CARCINOMA AT KURDISTAN CENTER FOR GASTROENTEROLOGY AND HEPATOLOGY
Authors: Ibrahim Abdullah , Lake Rebaz , Salih Karokh , Mohammed Mohammed 
Published: July 2019

Background Esophageal carcinoma is the sixth in cancer incidence and cancer related deaths. There are marked geographic variations in the incidence of different types and etiology/risk factors for esophageal carcinoma. Better understanding of the etiology/ risk factors may suggest opportunity for its primary prevention. Objectives To assess the demographic characteristics, etiology and risk factors of patients with esophageal carcinoma at Kurdistan Center for Gastroenterology and Hepatology. Materials and Methods A cross sectional study extended from March 2014 to December 2015; during this period100 patients with histologically diagnosed as esophageal carcinoma (EC) were included. Details about the demographic characteristics and risk factors for esophageal carcinoma had been reviewed. Results The mean age of the study population was 67±13.27 years. The male constituted 58% and female 42%, (75%) were Squamous cell carcinoma (SCC) and (25%) were Adenocarcinoma (AC). Up to 84% of AC cases were male (P value: 0.002). There was significant association beteewn type of esophageal cancer and tea drinking, temperature of tea and interval between tea being poured and drunken, P- value was 0.011, 0.031 and 0.001 respectively. There was no statistically significant association between types of EC and demographic characteristic, smoking and body mass index. Conclusion SCC was more common than AC; AC was more common in males. Drinking hot tea was associated with EC. Most patients were smoker and had low fruit and vegetable intake, with more dried and preserved foods intake.
USE OF LIPID PROFILE AS MARKER OF SEVERITY IN PRE-ECLAMPSIA
Authors: Mahmood Maryam 
Published: July 2019

Background
Pre-eclampsia is the major cause of maternal morbidity and mortality, preterm birth, perinatal death, and intrauterine growth restriction. The incidence of pre-eclampsia globally varies widely from 5-15 percentages. Studies result’s find correlation of essential hypertension with alteration of serum cholesterol, triglycerides and HDL-C, various studies claim that abnormal lipid synthesis leading to increase of thromboxane level and the decrease of prostaglandin levels.
Objectives
To assess changes in lipid profile in pre-eclampsia and if these changes can be used as a marker of severity of the condition.
Patients and Methods
Case-control Study at Sulaimani Maternity Teaching Hospital from 01. Feb. 2017 to 01. Aug. 2017, it includes 100 pregnant women divided into three groups. Control group who remained normotensive during study period and case group who subdivided to two group including those cases who developed mild and sever pre-eclampsia during study period.
Results
There was significant rise in the serum TC, TG, LDL and VLDL and decrease in HDL in pre-eclamptic groups compared to normal healthy pregnant women. When we compare patient with sever pre-eclampsia with patient with mild pre-eclampsia we found that women with sever pre-eclampsia has significantly higher level of TG (334.9 ± 97.8vs 250.2 ± 31.5) and VLDL (66.4 ± 19.8vs45.4 ± 12.7 only.
Conclusion
Maternal dyslipidemia early in second trimester may be an indicator for development of future pre-eclampsia.
BUPIVACAINE VERSUS LIDOCAINE LOCAL ANESTHESIA FOR OPEN CARPAL TUNNEL RELEASE: A RANDOMIZED COMPARATIVE STUDY
Authors: Saeed Areewan 
Published: July 2019

Background
Carpal tunnel syndrome is symptomatic compression of the median nerve at the wrist; surgery can be performed under general and local anesthesia. Local anesthesia is associated with shorter operative time and fewer coasts.
Objectives
To compare the use of Bupivacaine and Lidocaine when performing open carpal tunnel surgery.
Patients and Methods
We studied the visual analogue scale, intraoperative blood loss and postoperative intake of analgesics in 85 patients (100 wrists), whom divided randomly to two groups, each receiving one type of local anesthesia. Age range 20-80years, female 84 and one male, 61 patients having moderate and 24 having severe grades.
Results
The mean visual analogue score was significantly less in the first group the first10 hours, 7 days and 14 days postoperatively (p values 0.001, 0.001, 0.02), thereafter the mean difference was not significant (P value 0.06-0.11). Intra operative bleeding was significantly less in the bupivacaine group (66% ≤ 6 ml) when compared to the Lidocaine group, (92% ≥6ml and 59% having loss of 10 ml). The difference in consumption of acetaminophen in the first two weeks was statistically significant. In the first group 39 patients (76.4%) taking <15 grams, while in the second group 36 patients (73.4%) taking >15 grams.
Conclusion
Bupivacaine provides longer postoperative pain relief, less chance of long standing pain and significantly less intraoperative bleeding. The need for postoperative analgesia is significantly less making the procedure relatively safe and less coasty when using bupivacaine.
Телесно-ориентированная психотерапия: специфика, возможности, механизмы воздействия
Authors: Леви Татьяна Самуиловна 
Published: July 2019

<p>В статье раскрываются содержательные и этические основы телесно-ориентированной психотерапии, ее специфика и возможности в работе с различной психологической проблематикой. Расширение телесного осознавания, в процессе которого происходит изменение отношения человека к своему телу от объектного к субъектному рассматривается в качестве основного направления в деятельности телесного психолога.</p>
STUDY OF NEPETAE CATARIAE HERBA FRUITS AS PROMISING MEDICINAL PLANT RAW MATERIAL
Authors: Devyatov A. G. , Lapshin G. S. , Babaeva E. Yu. , Motina E. A. , Zvezdina E. V. , Vandishev V. V. 
Published: July 2019

Nepetae catariae herba is used in the Russian Federation as spice. The chemical compounds of herb have been studied. This plant has been introduced into the culture. There are its domestic varieties. The fruits of the plant accumulate up to 25% of fatty oil and contain specific laballenic acid, which has a wide range of antimicrobial and fungicidal actions. The yield of fruit crops is 5–6 c/ha.The aim is to study some criteria for the standardization of the quality of Nepetae catariae herb as a new medicinal plant raw material.Materials and methods. The studied fruits are from the biological collection of Federal State Budgetary Institution of All – Russia Research Institute of Medicinal and Aromatic Plants. Binocular magnifier brand MBS-10 and Axioplan 2 imaging microscope by Carl Zeiss were used. The sample preparation was carried out according to the State Pharmacopoeia of the Russian Federation (XIV edition). Anatomical diagnostic features were studied in powder and cross section with staining reagents for the presence of some biologically active substances. Qualitative reactions were carried out with water and alcohol-water extracts from the fruits. The content of the lipid complex according to pharmacopoeia monograph 2.5.0035.15 has been determined.Results. A description of the external and diagnostic anatomical features is given. The main groups of biologically active substances and the content of the lipid complex in a possible new material – the fruits of Nepeta cataria – have been identified.Conclusion. The description of the external features of the fruit has been specified. For the first time, crushed fruits have been characterized. It has been established that the morphology of endocarp cells and seed embryo cells are best preserved in a mellow fruit. Physico-optical properties of cellular structures and the ability for basic microchemical reactions are preserved in all zones of pericarp and seeds. Qualitative reactions showed the presence of the following components in the fruits: saponins, flavonoids and a lipid complex. A dispersion composition has been studied. The yield of the lipid complex and its appearance have been determined. Fruits can be used as promising fat-oil raw materials. The results of the study can be used in drafting Pharmacovigilance Reference Document considering a promising type of medicinal plant raw material on the basis of Nepetae catariae herba fruits.
STUDY OF BAICALIN HYDROLYSIS KINETICS IN THE PROCESS OF ITS EXTRACTION FROM SCUTELLARIA BAICALENSIS GEORGI ROOTS
Authors: Boyko N. N. , Pisarev D. I. , Zhilyakova E. T. , Maljutina A. Yu. , Novikov O. O. , Bocharnikova M. A. 
Published: July 2019

The aim of this study was to investigate the kinetics of baicalin hydrolysis in the process of its extraction from Scutellaria baicalensis Georgi roots.Materials and methods. For the studies, Scutellaria baicalensis Georgi roots with a particle range of 0.1–0.5 mm were used. The method of extraction was a simple maceration during a specified period of time, the ratio of plant raw material : extractant was 1:10 w/v at the temperature of 24±1°С. Baicalin and baicalein contents were analyzed by reverse phase high performance liquid chromatography (RP HPLC) at the analytical wavelength of 275 nm. The extractant was a water solution of ethanol 26, 43, 59, 72, 81, 97±1% v/v. The time of the extraction was from 1 to 24 hours.Results. The experimental points of dependency of baicalin concentration in the extract on the time of extraction for ethanol solutions with a concentration of 43 and 72% v/v are closely approximated by a linear equation in coordinates lnC=f(t). The value of determination coefficient is more than R²˃0,99. Half lifetime for baicalin has been calculated: for ethanol with the concentration of 43% v/v it is 4.3±0.7 hours, and for ethanol with the concentration of 72% v/v it is 42.3±1.8 hours.Conclusion. Baicalin hydrolysis kinetics in the process of its extraction from Scutellaria baicalensis Georgi roots with 43 and 72% v/v ethanol concentration. has been studied. It has been established that the process of baicalin hydrolysis is well described by the first order kinetic equation. The constants of baicalin hydrolysis during its extraction from Scutelaria baicalensis roots with ethanol having different concentrations have been calculated. Recommendations on technology optimization for baicalin or baicalein extraction from Scutellaria baicalensis Georgi roots have been given.
OPTIMIZATION OF THE METHOD FOR OBTAINING NANOCAPSULES, DEVELOPMENT OF THE METHODS OF DETERMINING THE DEGREE OF CINNARIZINE INCLUSION IN A PROLONGED DOSAGE FORM BASED ON POLY-D, L-LACTID-CO-GLICOLIDE, AND ITS VALIDATION
Authors: Sorokoumova M. V. , Blagorazumnaya N. V. , Kompantsev V. A. , Shcherbakova L. I. , Zyablitseva N. S. , Medvetskaya Yu. G. , Vasina T. M. , Miroshnichenko K. A. 
Published: July 2019

Common pathologies of the cardiovascular system are cerebrovascular disorders, for which cinnarizine is prescribed. An innovative, prolonged nanocapsule dosage form based on poly-D, L-lactide-co-glycolide (PLGA) has been developed.The aim of the research was improvement of the technology and development of the methods for determining the level of cinnarizine inclusion in nanocapsules. The research problem consisted of a great number of drug encapsulation peculiarities, as well as various physicochemical properties of the substances that cannot be taken into account in the existing methods of determination.Materials and methods. In the study, the following substances were used: cinnarizine, PLGA (50:50), polyvinyl alcohol (PVA). The remaining reagents and solvents fitted into the category of chemically pure. For development of the methods for quantitative determination of cinnarizine and its validation, a spectrophotometric method of analysis was used. Model mixtures used as objects of the study, had been prepared. Validation assessment of the methods was carried out upon such indicators as specificity, linearity, detection limit, repeatability, reproducibility.Results. Methods for spectrophotometric determination of the degree of cinnarizine inclusion has been developed. It has been established that encapsulation reaches 63.74%. Validation testing methods has been carried out. The results of such tests as specificity, linearity, detection limit, repeatability, reproducibility correspond to the safe range of values regulated by Product specification file. Due to the impossibility of determining the degree of cinnarizine inclusion on the basis of standard methods of preparation, the technology of producing nanocapsules has been adjusted.Conclusion. The technology has been optimized and new techniques have been developed. Taking into account the characteristics of production and the physicochemical properties of the components, they make a reliable analysis of the degree of cinnarizine inclusion in nanocapsules possible. The relative error of the developed methods of determination does not exceed ± 2.67%. Based on the results of the validation assessment, this methods is valid for all indicators.
MODERN MODEL FORMATION OF DRUG PROVISION OF PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA IN KABARDINO-BALKARIA
Authors: Umirova A. A. , Adzhienko V. L. , Kabakova T. I. , Korzhavykh E. A. , Gatsan V. V. 
Published: July 2019

The increase in the incidence of community-acquired pneumonia (СAP) is a major problem of national and regional importance. Its pharmacotherapy is based on the active use of antibacterial drugs. That requires a special attention of both, a doctor and a patient, the search for all new and advanced medicines (drugs).The aim of the study is to justify and develop a regional model of drug provision of pharmacotherapy in community-acquired pneumonia.Materials and methods. The use of the resource approach and the methodology of pharmaceutical care (PhC) for the formation of a modern model of drug supply have been tested. Logical, retrospective, sociological, pharmacoeconomic, marketing, statistical and other analytical methods have been used. The materials were official statistics, literature data and the results of the research carried out by the authors themselves.Results. The state and tendencies of development of organizational, personnel, financial (population) and drug resources as the external factors affecting PhC to patients with CAP in the Kabardino-Balkarian Republic (KBR) have been identified. The following internal factors of PhC have been defined: medical prescriptions, consumer demands and the cost of pharmacotherapy. A model of drug provision for patients with CAP in the region has been formed. It is aimed at increasing the effectiveness of treatment, taking into account the stage of treatment and the price factor.Conclusion. Under the conditions of a particular region, the use of the resource approach and the PhC methodology allows to more accurately identify the problems and risks of both drug provision and pharmacotherapy of the patients’ population under study, and form a model adequate to reality, develop recommendations for all participants of PhC – a doctor, a patient and a pharmaceutist (a pharmacist).
Pengaruh Permainan Tradisional Engklek Terhadap Perkembangan Kognitif Anak Usia 5-6 Tahun
Authors: Pertiwi Dwi Ana , Fitroh Siti Fadjryana , Mayangsari Dewi 
Published: July 2019

<em><span lang="IN">This study aims to determine the effect of traditional games on children cognitive development aged 5-6 years in TK Tarbiyatul Athfal Jaddih, Socah District Bangkalan rege. The game is able to increase affiliation with peers, reduce stress, and improve cognitive development. This game has been proved to increase affiliation with peers, reduce the pressure, and improve children cognitive development. This “englek” traditional games is utilized to stimulate cognitive development in the naming of numbers 1-20 and match numbers with symbols of numbers. This research employed quantitative method with Pre-experimental approach in the form of one group pretestposttest. Subjects in this study were 11 students aged 5-6 years in kindergarten Tarbiyatul Athfal. The data collection was carried out by conducting observation and documentation in the form images of the activities and daily lesson plan. Data analysis was executed by conducting statistical analysis technique of parametris in the form of t-test with data gathered from the result of pretest and posttest. The results obtained at the pretest, there were 2 children have low score and 9 children have been successfully on middle score. The Posttest was carried after giving treatment using “englek” traditional game found 2 children started to grow, 5 children developed as expected, and 4 children developed very well. The result of t-test showed that the value t <sub>count</sub> is -5,83 and t <sub>table</sub> 2,086, then -2,086&gt; -5,83 so that Ha was accepted. This finding shows that there is a significant effect of "englek" traditional game on children cognitive development aged 5-6 years in TK tarbiyatul athfal jaddih, Socah District Bangkalan Regency. </span></em>
Expression analysis of Rab11 during zebrafish embryonic development
Authors: Zhang Haijun , Gao Yu , Dong Zhangji , Hao Wenjin , Liu Dong , Duan Xuchu 
Published: July 2019

Abstract
Background: Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. In zebrafish, there are 3 rab11 paralogues, known as rab11a, rab11ba and rab11bb, sharing high identity with each other. However, the expression analysis of rab11 is so far lacking.
Results: Here, by phylogeny analysis, we found the three rab11 genes are highly conserved especially for their GTPase domains. We examined the expression patterns of rab11a, rab11ba and rab11bb using RT-PCR and in situ hybridization. We found that all the three genes were highly enriched in the central nervous system, but in different areas of the brain. Apart from brain, rab11a was also expressed in caudal vein, pronephric duct, proctodeum, pharyngeal arches and digestive duct, rab11ba was detected to express in muscle, and rab11bb was expressed in kidney, fin and spinal cord. Different from rab11a and rab11ba, which both have maternal expressions in embryos, rab11bb only expresses during 24hpf to 96hpf.
Conclusions: Our results suggest that rab11 genes play important but distinct roles in the development of the nervous system in zebrafish. The findings could provide new evidences for better understanding the functions of rab11 in the development of zebrafish embryos.
Lack of association between intraoperative handoff of care and postoperative complications: a retrospective observational study
Authors: O'Reilly-Shah Vikas N , Melanson Victoria G , Sullivan Cinnamon L , Jabaley Craig S , Lynde Grant C 
Published: July 2019

Abstract
Background:
The significance of intraoperative anesthesia handoffs on patient outcomes are unclear. While clearly an opportunity for inadequate communication, resulting in lapses of care, the literature has displayed mixed results. One possibility for this is inadequate treatment of confounding factors, such as patient comorbidities and surgery time of day. We performed this study to quantify the significance of confounding variables on composite adverse events during intraoperative anesthesia handoffs.
Methods:
In this retrospective study, we analyzed data from the American College of Surgeons National Surgical Quality Improvement Project (ACS NSQIP). We examined the effects of intraoperative handoffs between anesthesia personnel. A total of 12,111 cases performed examined at two hospitals in a single healthcare system that were that included in the ACS NSQIP database performed. The presence of attending and anesthetist or resident handoffs, patient age, sex, body mass index, American Society of Anesthesiologists Physical Status (ASA-PS) classification, case length, surgical case complexity, and evening/weekend start time were measured.
Results:
A total of 2,586 of all cases in the NSQIP dataset experienced a handoff during the case. When analyzed as a single variable, attending handoffs were associated with higher rates of adverse outcomes. However, once confounding variables were added into the analysis, attending handoffs and complete care transitions were no longer statistically significant.
Conclusions:
Inclusion of significant covariates is essential to fully understanding the impact provider handoffs have on patient outcomes. Case timing and lengthy case duration are more likely to result in both a handoff and an adverse event. Communication lapses during intraoperative handoffs are a potential source of medical error, the effects of which are difficult to quantify.
Comparison open liver resection and RFA on the treatment of solitary 3-5cm hepatocellular carcinoma
Authors: Lei Jianyong , Yan LN , Li DJ , Wang WT 
Published: July 2019

Abstract
Aim

The goal of this study is to compare the postoperative results of liver resection and radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) (3-5cm).

Patients and methods

We retrospectively collected 122 patients with small solitary HCC treated at our center, with diameters in the range of 3-5cm. According to the treatment program received at our center, they are divided into the liver resection group (72 cases) and the RFA group (50 cases).

Result

In comparison with the RFA group, the resection group requires a longer operative time, and the intra-operative blood loss is more (P<0.01); there is also more hepatic inflow occlusion, and the postoperative days of hospital stay are significantly longer (P<0.01). The 1-, 3-, and 5- year expected overall survival rates and tumor-free survival rates are comparable between two groups. Cox regression analysis showed that resection or RFA was not a significant risk factor for overall or tumor-free survival for HCC.

Conclusions

For solitary HCC of 3-5cm, RFA can achieve better hospital clinical results and similar long-term outcome, and RFA can be considered for wide application especially for central cases.
Palliative stenting in a newborn with critical coarctation of the aorta
Authors: Soynov I. , Kulyabin Yu. , Gorbatykh A. , Voytov A. , Omelchenko A. , Gorbatykh Yu. , Ivantsov S. , Arkhipov A. 
Published: July 2019

Newborns with critical coarctation of the aorta with a closed arterial duct often require surgical repair. Primary repair is associated with a high risk of unfavorable outcomes owing to severe systemic outflow obstruction and multiple organ failure. We present the case of a premature male newborn (weight = 1.9 kg) with critical coarctation of the aorta and multiple organ dysfunction syndrome with a closed arterial duct who successfully underwent isthmus stenting as a palliative step before surgical repair. The indication for primary stent implantation was decompensated metabolic acidosis. For stenting, the retroperitoneal approach was selected, and elective surgical cut-down of the right iliac artery was performed. Standard coronary stents (diameter = 4 mm; length = 13 mm) were delivered via a 4F sheath. The right iliac artery was repaired after sheath removal. The procedure was successful, and there were no procedural complications. Four days after stent implantation, the patient was stable, and he then underwent surgery. The coronary stent was extracted, the aortic isthmus was divided, and an extended anastomosis was created. The surgery was performed without complications. On the fourth day, the newborn was transferred from the intensive care unit to the ward, and on the fifteenth day, he was discharged from the hospital in good condition. Hence, palliative stenting is beneficial in newborns with critical aortic coarctation in the decompensated state because it stabilizes and prepares them for subsequent radical surgery, thereby reducing the risk of severe complications and mortality.
Received 3 October 2018. Accepted 11 December 2018.
Informed consent: The written informed consent has been obtained from the patient’s parents for this publication.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Acknowledgment: We express our gratitude to Melina G. Galstyan for technical support in article writing.