bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review
Authors: Mei Lin , Khurana Arushi , Al-Juhaishi Taha , Faber Anthony , Celi Francesco , Smith Steven , Boikos Sosipatros 
Published: March 2019

AbstractPheochromocytoma (PCC) and paraganglioma (PGL) are rare malignancies while pathogenesis is strongly influenced by genetics. The prognostic factors of these patients remain poorly defined. We aim to study the epidemiology and survival pattern by analyzing the combination of SEER and Cancer Genome Atlas (TCGA) database. Primary outcome was overall survival (OS) and disease specific survival (DSS). Between 1973 and 2013, a total of 1014 patients with PGL or PCC were analyzed. Younger age and female were associated with better outcomes. The incidence of second primary malignancy in PGL/PCC patients was about 14.6%. This population had a significant longer DSS. Other factors, including surgical resection and origin from of aortic/carotid bodies, conferred remarkable survival advantage. In contrast, distant spread portended worse prognosis. Laterality, race, positive serum catecholamine marker did not demonstrate a significant association with OS and DSS. By analyzing TCGA database with total 184 patients were identified. Eighty out of 184 patients (43.5%) had at least one pathogenic mutation. Female had higher ratio of pathogenic mutations than male (58.7% vs. 41.3%) and NF1 mutation was associated with elderly population. SHDB mutation had higher percentage in male. Twenty-nine patients (15.8%) had 2 or more primary. ATRX was the most common oncogenic mutations in metastatic cohort. In conclusion, younger age, female sex, origin from aortic/carotid bodies, complete surgical resection, regional disease, as well as concomitant second primary malignancies were associated with better prognosis. The prognostic value of radiotherapy and oncogenomics warrants further investigation.
Motivation und Diabetes – Zeit für einen Paradigmenwechsel? – Ein Positionspapier –
Authors: Petrak Frank , Meier Juris J. , Albus Christian , Grewe Petra , Dieris-Hirche Jan , Paust Rainer , Risse Alexander , Röhrig Bonnie , Herpertz Stephan 
Published: March 2019

ZusammenfassungÄrztliche Behandlungsempfehlungen bei Patienten mit Diabetes werden von den Betroffenen zu einem großen Teil nicht umgesetzt. Dies betrifft sowohl die Medikamenteneinnahme als auch Empfehlungen zu einem gesundheitsförderlichen Lebensstil mit entsprechender körperlicher Aktivierung, gesunder Ernährung, ggf. Beendigung des Rauchens und angemessener Gewichtskontrolle. Das Nichtbefolgen dieser Empfehlungen führt nachweislich zu einer deutlichen Risikoerhöhung für Diabeteskomplikationen, Morbidität und eine vorzeitige Mortalität. Ärztliche Reaktionen auf dieses Patientenverhalten umfassen verstärkte Bemühungen um „Therapietreue“ und resultieren langfristig nicht selten in einem Gefühl von Ohnmacht und Resignation. Forschungsbemühungen konzentrieren sich auf eine zunehmende Zahl von Interventionen zur Förderung der Therapieadhärenz, wobei die Ergebnisse von Metaanalysen auf einen nur mäßigen Erfolg hinweisen.Mit dem vorliegenden Positionspapier wird ein praxisorientierter Ansatz zur Diskussion gestellt, der auf eine Verbesserung der beschriebenen Problematik abzielt. Zentral ist dabei die Reflexion der verschiedenen Rollen sowie der Verantwortungsübernahme der Patienten auf der einen Seite und der Ärzte bzw. anderer Berufsgruppen (Diabetesberater, Psychotherapeuten) auf der anderen Seite. Es wird eine neue Klassifikation verschiedener Arten der Therapieadhärenz bzw. Non-Adhärenz vorgeschlagen. Diese bilden den Ausgangspunkt zu einem praxisbezogenen Algorithmus zum ärztlichen Umgang mit unterschiedlichen Arten der Therapieadhärenz, bei dem die Rollen und die Verantwortungen für Behandler und Patienten explizit geklärt werden. Dabei wird keine Therapieadhärenz von Patienten forciert. Vielmehr wird darauf abgezielt, dass Patienten eine informierte, tragfähige und eigenverantwortete Entscheidung für oder gegen einen ärztlichen Vorschlag treffen und dass dies von Behandlerseite akzeptiert werden kann, sodass Frustrationen und Ohnmachtsempfinden vermieden werden. Abschließend werden Thesen zum Umgang mit „Motivationsproblemen bei Diabetes“ zur Diskussion gestellt.
V2 Trigeminal Referred Pain from Chronic Occipital Neuralgia Caused by Entrapment of the Greater Occipital Nerve
Authors: Lee Chang-ik , Son Byung-chul 
Published: March 2019

AbstractAlthough entrapment of the greater occipital nerve (GON) is a well-known cause of occipital neuralgia, occurrence of referred hemifacial trigeminal pain involving V2 distribution from chronic occipital neuralgia is rare. A 67-year-old female patient with intermittent left-sided occipital neuralgia of 10-year duration presented with a new onset of left-sided hemifacial pain of 5-month duration. With aggravation of left-sided occipital neuralgia, continuous burning pain and paresthesia gradually developed in her left malar and periorbital area. They also spread to her left upper lip. Severe compression of the left GON by tendinous aponeurotic attachment of the trapezius was found intraoperatively. Decompression of the left GON from chronic entrapment resulted in immediate relief for her hemifacial pain and chronic occipital neuralgia. These findings provide clinical affirmation of the existence of trigeminal/cervical convergence and hypersensitivity. Chronic irritating afferent input of occipital neuralgia caused by entrapment of the GON seems to be associated with sensitization and hypersensitivity of the second-order neurons in the trigeminocervical complex receiving convergent input from dural and cervical structures. Referred trigeminal pain from chronic occipital neuralgia may extend to V2 in addition to V1 trigeminal distribution.
Changing Trends of Angiographic Profiles in Women with Coronary Artery Disease over a Decade
Authors: Aramalla Sunitha , Chakkera Priyanka 
Published: March 2019

Abstract
Background Cardiovascular diseases, especially coronary artery disease (CAD), have assumed epidemic proportions worldwide. CAD is the leading cause of disability and death in women. In woman during postmenopausal years, traditional risk factors tend to become very present and increase the risk for CAD. Patterns in epidemiology of CAD are doubtlessly changing continually in many ways, only some of which are recognized at any given point of time.
Aim To identify the changing trends of CAD in female patients who were admitted for coronary angiogram (CAG) over a period of 10 years.
Materials and Methods We retrospectively collected the data of female patients from our unit CAG registry. We noted the demographic data (age, ethnicity, socioeconomic status), clinical data (diabetic status, hypertension status, symptoms and their duration, past history), laboratory data (complete blood picture, cardiac enzymes, renal function tests, liver function tests, serum electrolytes), and CAG findings (normal coronaries [NC]/single-vessel disease [SCD]/double-vessel disease [DVD]/triple-vessel disease [TVD]) of the female patients in 2007 and a decade later that was 2017.
Results Data of 64 women in 2007 and of 184 in 2017 were analyzed. CAG women in 2017 were older than those in 2007 (53.1 ± 11.7 vs. 57.1 ± 12.3 years; p = 0.024). There was no significant difference found in the parameters such as hypertension (p = 0.797), diabetes mellitus (DM) (37.5% vs. 41.3%; p = 0.59), left ventricular (LV) dysfunction, type of presentation (acute coronary syndrome [ACS] or chronic stable angina [CSA]) and presence of CAD (53.9% vs. 51.1%; p = 0.69). In the 2017 female group, there was increase in detection of the electrographic (ECG) abnormalities (98.4% vs. 62.5%; p = 0.000). Radial route was used more frequently for CAG (98.4% vs. 40.6%; p = 0.000). Subgroup analysis of CAD (proven angiographically) showed a statistically significant difference of occurrence of SVD that was more frequent in 2007 female group (32.8% vs. 20.1%; p = 0.05), whereas TVD (was more frequent in 2017 female group (14.1% vs. 4.6%; p = 0.01).
Conclusion This study shows that even though there was no change in the incidence of occurrence of normal coronaries on angiogram over time; however, there was a significant increase in severity of the CAD (TVD) in 2017 female group (p = 0.01).
Outcomes of Patients after Implantation of the Pericardial All-Biological Valve No-React Aortic Conduit (BioIntegral) for Root Replacement in Complex Surgical Procedures
Authors: Puehler Thomas , Freitag-Wolf Sandra , Friedrich Christine , Salem Mohamed , Renner Jochen , Cremer Joachim , Haneya Assad 
Published: March 2019

Objective Therapy of complex aortic root pathologies remains a great surgical challenge. Though different graft materials are available to replace the often-destroyed aortic root, long durability and freedom from reoperation of the latter are still under debate. The aim of our study was to investigate patients' postoperative outcome after implantation of the BioIntegral conduit in complex aortic root pathologies.
Methods From February 2014 to May 2017, 33 consecutive patients (69.7% male) with a median age of 73 (57.5; 76.2) years underwent aortic root replacement with the BioIntegral conduit at our institution. Severe aortic valve endocarditis (78.8%) was the predominant indication for surgery. In 28 patients (84.9%), implantation was performed as redo or in 87.8% as urgent and emergent surgery. Primary end-point was the 30-day survival time, evaluated by Cox regression analysis. Secondary midterm outcome and graft-related reoperation were analyzed.
Results Median follow-up for all patients was 178 (8; 659) days. Median EuroScore II was 19.9% (13.4; 29.9). Freedom from reoperation was 97%. The overall 30-day mortality rate was 33% mainly caused by multiorgan failure in six (18.2%) patients and cardiac failure in five (15.1%) patients. One further death occurred during follow-up at day 156. None was directly conduit-related. Graft reinfection after the 4th surgery with basal abscess formation occurred in only one patient (3%). Early echocardiographic assessment of the valve revealed good functional results. A higher EuroScore II was significantly associated with a poorer 30-day survival time (hazard ratio, 1.039; 95% confidence interval, 1.015–1.063, p = 0.001).
Conclusion Aortic root replacement for complex pathologies is associated with substantial 30-day mortality, but survival of patients after discharge from hospital was stable. Early functional status of the BioIntegral valve was good. Though freedom from re-operation was low, long-term outcome and long-term functional status have to be further evaluated.
Minimally Invasive Plate Osteosynthesis for Periprosthetic and Interprosthetic Fractures Associated with Knee Arthroplasty: Surgical Technique and Review of Current Literature
Authors: Borade Amrut , Sanchez Daniela , Kempegowda Harish , Maniar Hemil , Pesantez Rodrigo , Suk Michael , Horwitz Daniel 
Published: March 2019

AbstractWith the increasing number of total knee arthroplasties (TKAs) being performed, the incidence of periprosthetic fractures adjacent to a TKA is rising. Minimally invasive plate osteosynthesis (MIPO) has proven to be successful for the biological fixation of many fractures. Advances in surgical instrumentation and techniques made MIPO possible for more complex fractures. Periprosthetic fractures are always complicated by problems of soft tissue incisions, scarring, and, of course, the arthroplasty components. MIPO techniques may be particularly suited to these injuries and may make the surgical repair of these fractures safer and more reliable. In this review, case examples are used to define the indications, preoperative planning, implant selection, complications, limitations, and challenges of MIPO for the treatment of periprosthetic fractures about the knee. When considering MIPO for any fracture, we recommend prioritizing an acceptable reduction with biological fixation and resorting to mini-open or open approach when necessary to achieve it. Awareness of the learning curve of the surgical technique, advances in implant designs, the tips and tricks involved, and the limitations of the MIPO is of paramount importance from the orthopaedic surgeon's perspective.
Nail–Plate Constructs for Periprosthetic Distal Femur Fractures
Authors: Mirick Mueller Gudrun 
Published: March 2019

AbstractOver the past several years, the nail–plate construct (NPC) has emerged as a novel construct for the treatment of challenging distal femoral periprosthetic fractures. This construct, which uses a combination of the two primary treatment methods—lateral locked plating and retrograde intramedullary nailing, creates hybrid stabilization and allows the potential for early mobilization. This article will give the rationale for the use of the NPC as well as a review of the current published literature reviewing its use.
The “Diagonal” Lesion: A New Type of Combined Injury Pattern Involving the Impingement Fracture of Anteromedial Tibial Plateau and the Injury of Posterior Cruciate Ligament and Posterolateral Corner
Authors: Li Xu , Song Guanyang , Li Yue , Liu Xin , Zhang Hui , Feng Hua 
Published: March 2019

AbstractThe purpose of this study was to investigate the incidence and clinical characteristics of the “diagonal” lesion. A total of 273 consecutive patients with combined posterolateral corner (PLC) and posterior cruciate ligament (PCL) injuries were retrospectively analyzed. All preoperative knee joint evaluations were reviewed including the computed tomography, the anteroposterior (AP) view, the lateral view, the full-length long-standing AP view, and the physical examination results with the patient under anesthesia. Twenty-six patients (9.5%) were verified as having the “diagonal” lesions. The anteromedial impingement fractures could be categorized into small (small fracture group, n = 7) and large (large fracture group, n = 19). The PCL injuries were classified into grade 2 (n = 22) and grade 3 (n = 4). The PLC injuries could be classified into type A (n = 3), type B (n = 8), and type C (n = 15) according to the Fanelli's classification system. Notably, there were 20 chronic cases. Among them, 14 (70%) had varus deformities. The proportion of patients with varus deformity in the large fracture group was significantly higher than that of the small fracture group (p = 0.026). In this study, the incidence of the “diagonal” lesions was 9.5%. Patients who had larger fracture size tended to develop subsequent varus deformity of the lower extremity. It was important for us to recognize the PCL/PLC injuries and to fully reduce the large bony fracture during the initial treatment of the “diagonal” lesions to prevent the residual instability and varus deformity.
Osteomeniscal Impact Edema (OMIE): Description of a Distinct MRI Finding in Displaced Flap Tears of the Medial Meniscus, with Comparison to Posterior Root Tears
Authors: Krych Aaron J. , Wu Isabella T. , Desai Vishal S. , Kennedy Nicholas I. , Littrell Laurel A. , Collins Mark S. , Saris Daniël B.F. , Stuart Michael J. 
Published: March 2019

AbstractBone marrow edema (BME) can be a late finding in osteoarthritis or a sign of subchondral insufficiency. The purpose of this study was to describe the magnetic resonance imaging (MRI) finding we refer to as “osteomeniscal impact edema” (OMIE), or reactive BME adjacent to a displaced meniscus flap tear. In addition, this edema pattern is compared with a control group of medial meniscus posterior root tears (MMPRT) with subchondral insufficiency edema. MRI records from 2000 to 2017 were retrospectively reviewed for studies that showed the presence of a medial meniscus displaced flap tear and an adjacent area of BME. The selected MRIs were matched to an equal number of MMPRT MRI studies. All MRI studies were assessed for cartilage surface grade using the modified Outerbridge classification system and for the extent of accompanying structural abnormalities using the whole-organ magnetic resonance imaging score. Descriptive statistics and hypothesis testing were utilized to compare the MRI findings between groups. Twenty-two flap tear (OMIE group) patients with a mean age of 57 (SD: 15) and 22 root tear (MMPRT) group patients with a mean age of 61 (SD: 10) were included. MRIs in the OMIE group showed a distinctive pattern of focal, peripheral edema adjacent to the meniscus flap tear, compared with more diffuse, central edema in the MMPRT group. Quantitatively, MRIs of the MMPRT group showed significantly worse mean femoral Outerbridge scores (3.72 vs. 2.68, p < 0.0001), more severe central (1.63 vs. 0.5, p = 0.0007) and posterior (0.31 vs. 0.0, p = 0.04) subchondral edema grades, and a higher incidence of tibial subchondral fractures (3 vs. 0, p = 0.036). Meniscus flap tears may present with a distinct MRI pattern of focal, adjacent, peripheral edema, which we refer to as OMIE. Patients with meniscus flap tears showed significantly less arthritic change, lower subchondral edema grades, and a lower incidence of insufficiency fractures and subchondral collapse compared with the diffuse overload edema pattern found with root tears. The Level of Evidence for this study is III.
Fabrication of Feeding Plate in Cleft Palate Patient: A Case Report
Authors: Lodhi Tulsi , Patil Surendra Kumar , Bahetwar Surendra Kumar , Sharma Aparna , Ninawe Nupur , Dolas Arti 
Published: March 2019

AbstractCleft lip and palate is one of the most common congenital craniofacial malformations. It is associated with various problems such as difficulty in sucking, nasal regurgitation, hearing and speech problems, etc. Feeding is of primary and immediate concern for the growth of infants. In this case report, a 3-month-old female child diagnosed with Veau's class II cleft reported with the difficulty in sucking of milk and nasal regurgitation while feeding. To overcome this problem, a feeding plate was fabricated with simple impression method, which helped the infant feed and restore the proper weight required for cleft palate reconstructive surgery.
Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution
Authors: Ye Xiang , Lin Jiabei , Mayne Leland , Shorter James , Englander S. Walter 
Published: March 2019

Significance
The cryo-EM revolution now provides snapshots of the structure of large protein molecular machines, but the fundamental mechanisms and principles that determine how they work have so far been elusive. What is needed is a technology that can investigate their architecture, structural dynamics, and energetics when they are active in physiological solution. This paper demonstrates the use of hydrogen exchange mass spectrometry methods to resolve all of the functionally active and inactive elements of Hsp104, characterize their interactions and dynamics, and uniquely their energetics. The results reveal in broad structural and energy-based terms how Hsp104 works. The methods used, the results obtained, and the energetic considerations that they suggest will be widely applicable to other ATPase-dependent protein machines.
Kujigamberoic acid A, a carboxylic acid derivative of kujigamberol, has potent inhibitory activity against the degranulation of RBL-2H3 cells
Authors: Takahashi Honoka , Shimoda Nozomu , Koshino Hiroyuki , Kimura Ken-ichi 
Published: March 2019

ABSTRACT
The aldehyde and carboxylic acid derivatives of kujigamberol were synthesized using pyridinium dichromate (PDC). The carboxylic acid derivative exhibited lower cytotoxicity and inhibited the degranulation of rat basophilic leukemia-2H3 (RBL-2H3) cells stimulated by thapsigargin more than kujigamberol. The carboxylic acid derivative was detected and isolated from the methanol extract of Kuji amber (MEKA) by the modified isolation procedure. Thus, it has been named as kujigamberoic acid A.
Possible Registration of Magnetic Particles in Biological Objects
Authors: Ichkitidze L P , Belodedov M V , Selishchev S V , Telishev D V 
Published: March 2019

Abstract
The possibility of non-invasive detection of magnetic particles in biological objects using magnetic field sensors of various types is investigated. Estimates of the threshold sensitivity of the sensors and the maximum distance at which the sensor can detect magnetic particles are made. It is shown that magnetite particles with a concentration of ∼ 10-9 vol.%, superparamagnetic particles and catalytic particles of the composition “iron in carbon nanotubes” can be fixed by SQUID or combined magnetic field sensors with operating temperatures ∼ 4 K at a distance of ≤ 0.1 m. It is noted that magnetic field sensors with ultra-low threshold sensitivity values (≤ 10-10 T) may be promising for non-invasive control of organs, implants, prostheses and other elements of biological systems.
Critical Current in the Strip Wires from the Josephson Medium
Authors: Belodedov M V , Ichkitidze L P , Selishchev S V 
Published: March 2019

Abstract
On the basis of the previously proposed phenomenological material equation of a superconducting granular medium, numerical simulation of some products from granular superconductors which include, in particular, products from high-temperature superconducting ceramics (and electrodynamic processes in them) is carried out. An expression is obtained for the first critical field of the medium in question and its relation to the phenomenological parameters of the medium. A strip wire model from a granular superconducting medium is constructed, the maximum current of these wires and its dependence on the external magnetic field were obtained. An analogue of the SQUID based on the strip from a granular superconductor is proposed, it is shown that its field characteristic has similarities with the field characteristics of the classical single-contact SQUID.
Combined Magnetic Field Sensor with Nanostructured Elements
Authors: Ichkitidze L P , Selishchev S V , Telyshev D V 
Published: March 2019

Abstract
A combined magnetic field sensor consisting of a magnetic field concentrator based on a superconducting ring film and a magnetically sensitive element with a spintronics structure is investigated. The active strip (narrowed part) of the concentrator is separated by an insulating film from the magnetically sensitive element, i.e. the combined magnetic field sensor is a sandwich. It has been established that the concentration coefficient of a sandwich-type magnetic field can be increased by fragmentation (nanostructuring) of the active band, in the form of several superconducting branches and cuts 20 nm wide. Increasing the number of incisions also reduces the threshold sensitivity of the sensor by several times. Nanostructured elements in the form of nanoscale sections in the active strip allow you to reduce the diameter of the concentrator ring, which allows the sensor to make the maximum linear size less than 1mm. It is noted that the considered combined magnetic field sensor with nanostructured elements has a high potential for detecting ultraweak magnetic fields (∼ 10 pT), and apparently, can be an alternative to SQUID.
Created, Changeable, and Yet Acausal?
Authors: Carr Vanessa 
Published: March 2019

AbstractAmongst the entities that have been created by human agents, and can be changed by human agents, besides concrete particulars, such as tables and chairs, our intuitions suggest that there are repeatables—entities that can each have multiple concrete instances. And since there is reason to think that repeatables are acausal, there is reason to think that that there are entities that are created, changeable, repeatable and acausal. Then again, it might be supposed that if an entity is created then it is causal, and that if an entity is changed then it is causal. It is argued here that these suppositions are insufficiently motivated to undermine the case for the existence of entities that are created, changeable, repeatable and acausal.