bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migration and Phenotype Control of Human Dermal Fibroblasts by Electrospun Fibrous Substrates
Authors: Chen Huizhi , Lui Yuan Siang , Tan Zhen Wei , Lee Justin Yin Hao , Tan Nguan Soon , Tan Lay Poh 
Published: March 2019

AbstractElectrospun fibrous matrices, mimicking extracellular matrix (ECM) hierarchical structures, are potential scaffolds for wound healing. To design functional scaffolds, it is important to explore the interactions between scaffold topographic features and cellular responses, especially directional migration and phenotypic changes, which are critical functional aspects during wound healing. Here, accelerated and persistent migration of human dermal fibroblasts (HDFs) is observed on fibers with aligned orientation. Furthermore, aligned fibers can induce fibroblast‐to‐myofibroblast differentiation of HDFs. During wound healing, the presence of myofibroblasts advances wound repair by rendering contractile force and ECM deposition within the early and middle courses, but its continuous persistence in the later event may not be desired due to the contribution in pathological scarring. To tune the balance, it is noted in this work that the introduction of matricellular protein angiopoietin‐like 4 (ANGPTL4) is capable of reversing the phenotypic alteration induced by aligned fibers, in a time‐dependent manner. These results indicate fibrous matrices with oriented configuration are functional in mediating directional cell migration and phenotypic change. The discoveries further suggest that tissue‐engineered fibrous grafts with precise alignment modulation and ANGPTL4 releasing properties may thus be promising to promote wound repair with minimizing scar formation.
tert‐Butoxide‐Mediated Synthesis of 3,4′‐Biquinolines from 2‐Aminochalcones
Authors: Jeon Jiye , Lee So Young , Cheon Cheol‐Hong 
Published: March 2019

AbstractA novel protocol to synthesize 3,4’‐biquinolines from 2‐aminochalcones in the presence of a stoichiometric amount of sodium tert‐butoxide as the nucleophilic promotor was developed. Conjugate addition of tert‐butoxide to 2‐aminochalcones provided the corresponding enolates, which underwent Michael addition to another molecule of 2‐aminochalcone to afford a dimeric species of 2‐aminochalcones. Subsequent cyclization between the amino and carbonyl groups followed by aromatization provides 3,4’‐biquinoline products. Various 2‐aminochalcones were submitted to this protocol and the desired 3,4’‐biquinoline products were obtained in good to high yields in a short reaction time.magnified image
Disgust sensitivity in relation to menstrual cycle phase in women with and without an infection
Authors: Milkowska Karolina , Galbarczyk Andrzej , Jasienska Grazyna 
Published: March 2019

AbstractObjectivesThe compensatory prophylaxis hypothesis (CPH) proposes that evolved psychological mechanisms enhance the avoidance of potential contaminants during periods of reproductive immunomodulation in order to decrease a chance of infection. However, the results of previous studies are inconclusive. Our aim was to investigate the differences in disgust sensitivity during phases of menstrual cycle in regularly cycling young healthy women and among women who reported having an infection.MethodsThe disgust sensitivity was measured using Two Domains of the Three Domain Disgust Scale (TDDS), Padua Inventory (PI), and photographs during the internet‐based survey. Women (N = 527) were divided by phases of menstrual cycle using two different methods on the basis of reported cycle length and the number of days since the onset of their most recent menstrual bleeding.ResultsThe women who had an infection and who were in luteal phase had higher scores in Pathogen Disgust Domain than women in follicular phase. However, they did not differ in other assessments of disgust sensitivity.ConclusionsThe results provide weak support for the CPH hypothesis. We found differences in disgust sensitivity in women who declared having an infection—participants in the luteal phase scored higher in the Pathogen Domain Scale of TDDS than women in the follicular phase. We suggest that future studies should measure levels of sex steroids and immunological markers of infection.
Oxidative Annulation of Acetanilides with Alkynes Catalyzed by Cyclopentadienyl Rhodium(III) Complexes with Pendant Amides
Authors: Yoshimura Ryo , Shibata Yu , Yoshizaki Soichi , Terasawa Jyunichi , Yamada Takayuki , Tanaka Ken 
Published: March 2019

AbstractIt has been established that a cationic cyclopentadienyl (Cp) rhodium(III) complex with a pendant N‐phenylcarbamoyl moiety (CpA1RhIII) showed high catalytic activity towards the oxidative [3+2] annulation of acetanilides with internal alkynes to produce substituted indoles. Catalytic activity of the CpA1RhIII complex in the reactions of symmetric internal alkynes (diphenylacetylene and 6‐dodecyne) was higher than that of the Cp*‐rhodium(III) complex and comparable to that of a Cp‐rhodium(III) complex with two ethoxycarbonyl groups (CpERhIII). On the other hand, the CpA1RhIII complex showed significantly higher catalytic activity than the CpERhIII complex in the reactions of unsymmetric internal alkynes (1‐phenyl‐1‐propyne and 1‐phenyl‐1‐hexyne). Additionally, the catalytic activity of the CpA1RhIII complex in the oxidative tandem [2+2+2] annulation‐lactamization of acetanilides with two unsymmetric electron‐deficient internal alkynes (ethtyl 2‐butynoate) was also comparable to that of the CpERhIII complex.
Reversible Nature of Coke Formation on Mo/ZSM‐5 Methane Dehydroaromatization Catalysts
Authors: Kosinov Nikolay , Uslamin Evgeny A. , Meng Lingqian , Parastaev Alexander , Liu Yujie , Hensen Emiel J. M. 
Published: March 2019

AbstractNon‐oxidative dehydroaromatization of methane over Mo/ZSM‐5 zeolite catalysts is a promising reaction for the direct conversion of abundant natural gas into liquid aromatics. Rapid coking deactivation hinders the practical implementation of this technology. Herein, we show that catalyst productivity can be improved by nearly an order of magnitude by raising the reaction pressure to 15 bar. The beneficial effect of pressure was found for different Mo/ZSM‐5 catalysts and a wide range of reaction temperatures and space velocities. High‐pressure operando X‐ray absorption spectroscopy demonstrated that the structure of the active Mo‐phase was not affected by operation at elevated pressure. Isotope labeling experiments, supported by mass‐spectrometry and 13C nuclear magnetic resonance spectroscopy, indicated the reversible nature of coke formation. The improved performance can be attributed to faster coke hydrogenation at increased pressure, overall resulting in a lower coke selectivity and better utilization of the zeolite micropore space.
Isolierung eines diylidstabilisierten Stannylens und Germylens: Erhöhte Donorstärke durch coplanare Anordnung freier Elektronenpaare
Authors: Mohapatra Chandrajeet , Scharf Lennart T. , Scherpf Thorsten , Mallick Bert , Feichtner Kai‐Stephan , Schwarz Christopher , Gessner Viktoria H. 
Published: March 2019

AbstractDie Darstellung des ersten stabilen, diylidsubstituierten Stannylens und Germylens Y2E (mit E=Ge, Sn und Y=[PPh3‐C‐SO2Tol]−) wird berichtet. Die Synthese gelingt in einem Schritt durch die einfache Umsetzung des metallierten Ylids YNa mit der entsprechenden Vorstufe ECl2. Y2Ge und Y2Sn weisen eine ungewöhnliche Struktur sowohl im Festkörper als auch in Lösung auf, bei der die drei freien Elektronenpaare der zentralen C‐E‐C‐Einheit coplanar zueinander angeordnet sind. DFT‐Studien zeigen, dass aufgrund der starken anionenstabilisierenden Eigenschaften der Sulfonylgruppen im Ylidrückgrat und deren Koordination an das Metall diese Bindungssituation gegenüber der typischen π‐Donation des Liganden in das freie p‐Orbital des Metalls bevorzugt wird. Die Ausrichtung der drei freien Elektronenpaare führt zu einer deutlichen Erhöhung der HOMO‐Energie und damit der Donorstärke der Tetrylene. Hierdurch werden Y2Ge und Y2Sn zu stärkeren Donoren als ihre diamin‐ oder diarylsubstituierten Analoga und vergleichbar mit cyclischen Alkyl(amino)carbenen. Erste Reaktivitätsstudien bestätigen die hohe Reaktivität von Y2Ge und Y2Sn, welche zum Beispiel intramolekulare C‐H‐Aktivierungen mittels Metall‐Ligand‐Kooperation eingehen.
Validating the Biphilic Hypothesis of Nontrigonal Phosphorus(III) Compounds
Authors: Lee Kyounghoon , Blake Anastasia V. , Tanushi Akira , McCarthy Sean M. , Kim Daniel , Loria Sydney M. , Donahue Courtney M. , Spielvogel Kyle D. , Keith Jason M. , Daly Scott R. , Radosevich Alexander T. 
Published: March 2019

AbstractConstraining σ3‐P compounds in nontrigonal, entatic geometries has proven to be an effective strategy for promoting biphilic oxidative addition reactions more typical of transition metals. Although qualitative descriptions of the impact of structure and symmetry on σ3‐P complexes have been proposed, electronic structure variations responsible for biphilic reactivity have yet to be elucidated experimentally. Reported here are P K‐edge XANES data and complementary TDDFT calculations for a series of structurally modified P(N)3 complexes that both validate and quantify electronic structure variations proposed to give rise to biphilic reactions at phosphorus. These data are presented alongside experimentally referenced electronic structure calculations that reveal nontrigonal structures predicted to further enhance biphilic reactivity in σ3‐P ligands and catalysts.
Excitation Wavelength Dependent Fluorescence of an ESIPT Triazole Derivative for Amine Sensing and Anti‐Counterfeiting Applications
Authors: Zhang Yujian , Yang Heyi , Ma Huili , Bian Gaofeng , Zang Qiguang , Sun Jingwei , Zhang Cheng , An Zhongfu , Wong Wai‐Yeung 
Published: March 2019

AbstractExcitation wavelength dependent (Ex‐De) emission materials have potential applications in anti‐counterfeiting labels and bioimaging. Nevertheless, few purely organic chromophores are used in these areas. In this study, multiple excited states were incorporated into a molecule that was excited state intramolecular proton transfer (ESIPT) active, with the goal of manipulating the relaxation pathways of the excited states. The triazole derivative exhibits Ex‐De photoluminescence (PL), and the maximum PL wavelength is located at 526 nm and 593 nm under a series of excitation wavelengths. Spectral identification indicates that the excimer and ESIPT processes are responsible for the green (526 nm) and orange (593 nm) fluorescence, respectively. Importantly, the quick response code and test strip prepared with this triazole derivative can be used for anti‐counterfeiting and food spoilage detection applications, respectively. This research opens the door for developing novel Ex‐De materials for anti‐counterfeiting purposes.
Radiation synthesis of polysilane‐modified graphene oxide for improving thermal conductivity and mechanical properties of silicone rubber
Authors: Dai Pei , Jiao Yang , Ma Huiling , Zeng Xinmiao , Lu Yongjun , Wang Liancai , Bao Mao , Zhai Maolin 
Published: March 2019

ABSTRACTFunctionalized graphene oxide (named GO‐Si) was synthesized with graphene oxide and triethoxyvinylsilane (TEVS) using tetrahydrofuran solution by γ‐ray irradiation. TEVS was successfully covered onto GO sheets, and the polysilane content on GO‐Si was increased upon increasing the absorbed dose. The structures of GO‐Si were verified by atomic force microscopy, Fourier transform infrared spectroscopy, and X‐ray photoelectron spectroscopy. The resultant GO‐Si was dispersed into α,ω‐dihydroxypolydimethylsiloxane to prepare room temperature vulcanized silicone rubber composites (named SR/GO‐Si) by solution casting. The dispersion of GO‐Si was more uniform than that of GO. Compared to that of pure SR, the thermal conductivity of SR/GO‐Si‐1.95 composites was increased 1.5‐fold, and its tensile strength and elongation at break increased 78.6 and 71.4%, respectively. It was expected that SR/GO‐Si would have potential application as the thermal interface material. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47776.
Quantitative study of the capillaries within the white matter of the Tg2576 mouse model of Alzheimer's disease
Authors: Zhang Yi , Chao Feng‐lei , Zhang Lei , Jiang Lin , Zhou Chun‐ni , Chen Lin‐mu , Lu Wei , Jiang Rong , Tang Yong 
Published: March 2019

AbstractIntroductionTo quantitatively investigate the capillaries within the white matter of Tg2576 Alzheimer's disease (AD) transgenic mice during the early stage.MethodsIn the current study, 10‐month‐old male Tg2576 AD mice were used as the early‐stage AD group and age‐matched nontransgenic littermate mice were used as the wild‐type group. Then, the Morris water maze was used to examine the spatial learning and memory abilities of the mice in both groups, and unbiased stereological methods were used to accurately quantify the volume of white matter and the parameters of the capillaries within the white matter, such as the total length, total volume, and total surface area of capillaries.ResultsThe Morris water maze performance of the Tg2576 group was worse than that of the wild‐type group, while the white matter volume did not significantly differ between the wild‐type group and the Tg2576 group. The total length, total volume, and total surface area of the capillaries within the white matter of the Tg2576 group were significantly decreased compared to those of the wild‐type group.ConclusionsThe current study provide structural basis for understanding the pathological changes of the early stage of AD and cognitive decline in AD might be associated with changes in the white matter capillaries. Capillaries within the white matter might, thus, serve as a valid target for the prevention and treatment of early‐stage AD.
The dark figure of sexual recidivism
Authors: Scurich Nicholas , John Richard S. 
Published: March 2019

Empirical studies of sexual offender recidivism have proliferated in recent decades. Virtually all of the studies define recidivism as a new legal charge or conviction for a sexual crime, and these studies tend to find recidivism rates of the order of 5–15% after 5 years and 10–25% after 10+ years. It is uncontroversial that such a definition of recidivism underestimates the true rate of sexual recidivism because most sexual crime is not reported to legal authorities, a principle known as the “dark figure of crime.” To estimate the magnitude of the dark figure of sexual recidivism, this paper uses a probabilistic simulation approach in conjunction with the following: (i) victim self‐report survey data about the rate of reporting sexual crime to legal authorities; (ii) offender self‐report data about the number of victims per offender; and (iii) different assumptions about the chances of being convicted of a new sexual offense given that it is reported. Under any configuration of assumptions, the dark figure is substantial, and as a consequence the disparity between recidivism defined as a new legal charge or conviction for a sex crime and recidivism defined as actually committing a new sexual crime is large. These findings call into question the utility of recidivism studies that rely exclusively on official crime statistics to define sexual recidivism, and highlight the need for additional, long‐term studies that use a variety of different measures to assess whether or not sexual recidivism has occurred.
Esthetic Management of Peripheral Giant Cell Granuloma Affecting a Dental Implant in the Esthetic Zone
Authors: Mordini Lorenzo 
Published: March 2019

IntroductionA size increase of the gingiva can be a manifestation of gingival disease. While gingival lesions can affect periodontal tissue, only few reports described the association between peripheral giant‐cell granuloma (PGCG) with dental implants and their clinical management. Their clinical relevance is of a great interest since some lesions may lead to extensive bone resorption, esthetic alterations, or even tooth/implant loss. To the author's best knowledge, no specific guidelines for the treatment of PGCG affecting dental implant in the esthetic zone have been reported. The aim of this paper was to report an extensive PGCG associated with a dental implant in the esthetic area and its surgical management.Case PresentationA 39‐year‐old suffered from concussive trauma on her anterior maxillary dentition leading to an expanded, purplish soft tissue lesion surrounding the implant provisional crown on right central maxillary incisor. After complete lesion excision, the implant neck was carefully and gently debrided. Histological analysis confirmed the diagnosis of PGCG. The patient was then evaluated weekly for the first 3 weeks then monthly. No episodes of recurrence were identified. After 16 weeks of undisturbed healing, a soft tissue augmentation via tunnel technique was elected as the first treatment option to improve esthetics. Final implant restoration was delivered. Follow up at 22 months from biopsy excluded any recurrence of PGCG with stability of peri‐implant soft tissues.ConclusionExcisional biopsy, careful removal of irritating factors, monitoring, and connective tissue grafting can esthetically improve a malpositioned implant and showed no recurrence over a period of 22 months.
Long‐Term Outcome (10 Years) of Multiple Recession‐Type Defects Treated With Acellular Dermal Matrix Graft and Coronally Advanced Flap: A Case Report
Authors: Schinini Guillermo , Romanelli Hugo , Chambrone Leandro 
Published: March 2019

IntroductionThere is limited evidence related to the long‐term treatment outcomes of acellular dermal matrix graft (ADMG) plus coronally advanced flap (CAF) for the treatment of multiple recession defects. The aim of this case report is to assess the short‐ and long‐term clinical outcomes of Miller Class I multiple gingival recession‐type defects in the maxilla treated with ADMG plus CAF.Case PresentationA 36‐year‐old female patient smoking < five cigarettes per day presented multiple adjacent Miller Class I gingival recession in the left maxilla and was referred for treatment with chief complaints of dental hypersensitivity and esthetics. Root coverage was achieved by ADMG + CAF and the patient underwent a 10‐year follow‐up.ConclusionsWithin the limits of this case report, mean root coverage obtained at 6 months could not be maintained in the long term. A significant relapse was detected after 10 years, from 80% complete root coverage (CRC) at 6 months to 40% at 10 years. Monitoring, compliance, and reinstructions in oral hygiene techniques seem mandatory for minimizing relapse of gingival recessions after root coverage procedures.
Luminescent Rhenium(I)–Polypyridine Complexes Appended with a Perylene Diimide or Benzoperylene Monoimide Moiety: Photophysics, Intracellular Sensing, and Photocytotoxic Activity
Authors: Yip Alex Man‐Hei , Shum Justin , Liu Hua‐Wei , Zhou Huipeng , Jia Meiqi , Niu Niu , Li Yongxin , Yu Cong , Lo Kenneth Kam‐Wing 
Published: March 2019

AbstractThis communication reports novel luminescent rhenium(I)–polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non‐conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol‐sensing capability and excellent photocytotoxic activity.
Optimization of Aqueous Stability versus π‐Conjugation in Tetracationic Bis(triarylborane) Chromophores: Applications in Live‐Cell Fluorescence Imaging
Authors: Griesbeck Stefanie , Ferger Matthias , Czernetzi Corinna , Wang Chenguang , Bertermann Rüdiger , Friedrich Alexandra , Haehnel Martin , Sieh Daniel , Taki Masayasu , Yamaguchi Shigehiro , Marder Todd B. 
Published: March 2019

AbstractThe stability of tetracationic triarylboranes in dilute aqueous solution was investigated by tuning the steric demand of the linker in a (para‐(N,N,N‐trimethylammonio)xylyl)2B–(linker)–B(para‐(N,N,N‐trimethylammonio)xylyl)2 structure. With increasing steric bulk of the linker, namely 1,4‐phenylene, 2,2′′′‐(3,3′′′‐dimethyl)‐5,2′:5′,2′′:5′′,5′′′‐quaterthiophene, 9,10‐anthracenylene, and 4,4′′′‐(5′‐(3,5‐dimethylphenyl))(5′′‐(3′′′,5′′′‐dimethylphenyl))‐2′,2′′‐bithiophene, the stability of the compounds increased. The anthracene‐based chromophore, compound 3M is water‐stable for at least 48 h, is nontoxic to cells and exhibits an exceedingly high fluorescence quantum yield of 0.86 in water making it an ideal candidate for confocal live‐cell imaging of lysosomes.
Rhodium‐Catalyzed Alkylation of C−H Bonds in Aromatic Amides with Non‐activated 1‐Alkenes: The Possible Generation of Carbene Intermediates from Alkenes
Authors: Yamaguchi Takuma , Natsui Satoko , Shibata Kaname , Yamazaki Ken , Rej Supriya , Ano Yusuke , Chatani Naoto 
Published: March 2019

AbstractThe alkylation of C−H bonds (hydroarylation) in aromatic amides with non‐activated 1‐alkenes using a rhodium catalyst and assisted by an 8‐aminoquinoline directing group is reported. The addition of a carboxylic acid is crucial for the success of this reaction. The results of deuterium‐labeling experiments indicate that one of deuterium atoms in the alkene is missing, suggesting that the reaction does not proceed through the commonly accepted mechanism for C−H alkylation reactions. Instead the reaction is proposed to proceed through a carbene mechanism. The carbene mechanism is also supported by preliminary DFT calculations.
Empirical likelihood confidence intervals under imputation for missing survey data from stratified simple random sampling
Authors: Cai Song , Qin Yongsong , Rao J. N. K. , Winiszewska Malgorzata 
Published: March 2019

AbstractMissing observations due to non‐response are commonly encountered in data collected from sample surveys. The focus of this article is on item non‐response which is often handled by filling in (or imputing) missing values using the observed responses (donors). Random imputation (single or fractional) is used within homogeneous imputation classes that are formed on the basis of categorical auxiliary variables observed on all the sampled units. A uniform response rate within classes is assumed, but that rate is allowed to vary across classes. We construct confidence intervals (CIs) for a population parameter that is defined as the solution to a smooth estimating equation with data collected using stratified simple random sampling. The imputation classes are assumed to be formed across strata. Fractional imputation with a fixed number of random draws is used to obtain an imputed estimating function. An empirical likelihood inference method under the fractional imputation is proposed and its asymptotic properties are derived. Two asymptotically correct bootstrap methods are developed for constructing the desired CIs. In a simulation study, the proposed bootstrap methods are shown to outperform traditional bootstrap methods and some non‐bootstrap competitors under various simulation settings. The Canadian Journal of Statistics 47: 281–301; 2019 © 2019 Statistical Society of Canada