bluuebunny/crossref_metadata_2025_split huggingface dataset:
The studing of antimicrobial activity of 4-(R-ylidenamino)-3-( morpholinomethylene)-4H-1,2,4-triazole-5-thiol
Authors: Shcherbyna R. О. , Panasenko O. I. , Knysh Ye. H. , Kamyshnyy O. M. 
Published: September 2019

According to the information of the World Health Organization (WHO) the lethal cases caused by pathogenic microorganisms occupied the one of the leading places. Most acutely the problem posed in countries where economic opportunities does not hold the flashes of infectious diseases under control. Therefore necessity of the new, available and high bactericidal drugs is reasonable and justified. Unfortunately, in literary sources missing information which devoted to 4-(R-ylidenamino)-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thioles.
The main aim of our work are studying antimicrobial and antifungal properties of 4-(R-ylidenamino)-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thioles by serial dilutions method and establishing some patterns dependence "structure-action". The research was conducted by using of standard test cultures: Staphylococcus aureus, Escherichia coli, Pseudomоnas aeruginosa, Candida albicans. The trimethoprimum was used as reference preparation for antimicrobial activity studying, the nystatinum – for antifungal.
Thus, the most pronounced antimicrobial action during the experiment shows 3-(morpholinomethylen)-4-(((5-nitrofuran-2-yl)methylene)amino)-4H-1,2,4-triazole-5-thiol (2.18) and 3-(morpholinomethylen)-4-((3-(5-nitrofuran-2-yl)allylidene)amino)-4H-1,2,4-triazole-5-thiol (2.19) which exceeds the standard comparison drug trimethoprimum. The researching of compounds 2.1–2.21 has specified the absence of pronounced antifungal properties for a reference strain of C. albicans. Some regularities of the influence structure of tested substances for the pharmacological activity were established, and they can be useful in future searching of highly effective antimicrobial drugs.
Comparative analysis of medications for local treatment of burns on national and foreign markets
Authors: Vons В. V. , Chubka M. B. , Groshovyi T. A. , Stechyshyn I. P. 
Published: September 2019

Burn wound treatment issues remain relevant in modern medicine, since burns are among the most common types of injuries and rank third among all types of injury in peacetime. The problem of treatment of burn injuries are determined by the high frequency of their occurrence, the complexity and duration of treatment of such patients, with serious consequences.
To date, in the world there are a large number of drugs for local treatment of burns in various forms (ointments, gels, creams, aerosols, solutions for external use, patches) and biological drugs are also used.
The aim of the work was to conduct a comparative analysis of the range of registered medicinal products for local treatment of burns on the national market, with preparations of this segment of the market, registered in Georgia and France. Georgia is a country, which is not a member of the European Union, and France is one of the five countries leading exporters of medicines and is a member of the European Union, in order to determine the relevance and feasibility of developing new drugs. In the analysis of drugs registered in the pharmaceutical markets of France and Georgia, those drugs that have no analogues in Ukraine, for the most part are patches (patches), considering in more detail.
The study of the nomenclature assortment of drugs carrying out in accordance with the State Register of drugs and the Anatomical-Therapeutic-Chemical Classification, as an information source was used Compendium, online-directories and online-pharmacу.
According to the results of the research conducted on the end of 2018, in Ukraine there are about 105 drugs, production in various forms that is directly used for local treatment of burns. In the pharmaceutical markets of Georgia and France, this amount of drugs is respectively 101 and 64 drugs. In all three countries, most medications for local treatment of burns presented in soft drugs, in particular, in Ukraine 67.58%, in Georgia 84.16% and in France 39.06%, respectively. In Ukraine, 58.33% of all drugs for local treatment of burns domestically produced, but in Georgia and France, the proportion of such drugs is significantly lower, namely 11.88% and 32.81% respectively.
The comparative analysis conducted by us proved that in the pharmaceutical markets of France and Georgia there were registered drugs in the form of patches that are widely used in the treatment of burn injuries, the analogues of which are absent in Ukraine.
These studies prove the prospect of expanding the range of existing ursus forms and creating a new group of original drugs that would stimulate regenerative skin processes and improve wound healing.
Scientific methodology and practical use of managed entry agreements for innovative medicines in system of health technology assessment in Ukraine
Authors: Zaliska O. M. , Stasiv KH.-O. J. 
Published: September 2019

In the Health Technology Assessment (HTA) system, it is advisable to use a mini-HTA to save budget funds at the hospital level, taking into account real world data on drug consumption for a rational use of resources at the local level. HTA include Managed Entry Agreements (MEA), which is being actively implemented in Europe to ensure the availability of innovative medicines for the treatment of oncological, hematological, rare diseases, assisted reproductive technologies (ART), and government funding programs.
The aim of this study was to analyze the use of the mini-HTA approach for the evaluation of innovative drugs, in particular with ART. Theoretically and practically substantiate the «Managed Entry Agreement» methodology for innovative drugs for rapid availability to new medicines based on evidence-based medicine and pharmacoeconomics for implementation at the state (local) level and rational use of budget funds.
Research methods – systematic analysis of data of reports, publications about the mini-HTA and the «Managed Entry Agreement» in the leading countries of Europe. The main objects were articles, reviews of pharmacoeconomists of ISPOR, LSE, which are leading in the HTA field in the world. The statistical data on innovative drugs, included in the legislatively regulated by the MEA in the EU, Central and Eastern Europe countries, using the methods of generalization, systematic analysis were studied.
We summarized the HTA data include in mini-HTA reports in EU countries, which were legally regulated and included innovative drugs for the treatment of cancer, hematological and rare diseases. We established that using 6 main MEA methods, regulated by law in the EU countries. There is necessary to create a recommendation on mini-HTA and MEA to improve the regulatory framework and activities of the HTA Department of State Expert Centre, MoH of Ukraine in order to implementation of the State strategy for implementing the State policy of providing the population with medicines for the period up to 2025.
We formulated the term «mini-HTA» as a systematic process of evaluating indicators of effectiveness, safety, quality of life, social and ethical aspects in relation to the costs for innovative drugs to save budget resources at the local level. There is advisable to use the MEA methods to estimate the cost for treatment regimens, including drugs for ART, which will ensure the rational use of funds for state programs, in particular, for the treatment of infertility, and public health resources.
Anticonvulsant activity of 5-(furan-2-yl)-4R1-1,2,4-triazole-3-thione S-derivatives
Authors: Parchenko V. V. 
Published: September 2019

Among the huge number of drugs registered in Ukraine anticonvulsants occupy a special place. They are mainly used for the relief of different etiology seizures. Along with the principal pharmacological action of drugs in this group there were exhibited a number of unwanted side effects. Therefore the question of the searching for new biologically active molecules, remains relevant today and is necessary for the further practical introduction into medical practice.
The purpose of our work was to study the anticonvulsant activity of 5- (furan-2-yl) -4R1-1,2,4-triazole-3-thione S-derivatives.
The anticonvulsant activity study of the 5-(furan-2-yl)-2H-1,2,4-triazole-3-thione S-derivatives and 5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiones were conducted on the test of interaction with agents that stimulate the central nervous system. The theoretical computer predictions indicate the prospects in searching among the represented compounds classes. The criteria for assessing anticonvulsant activity were the changings in attack seizures latency and their duration. Reference drugs were Mydocalmum and Phenobarbital. Among the studied substances two compounds had the highest activity which is equivalent in strength to the activity of reference drugs.
Two compounds among the studied substances have the highest activity which is equivalent in strength to Mydocalm activity/ Also 2-[5-(furan-2-yl)-4-fenil-4H-1,2,4-triazole-3-ylthio]-1-(4-chlorfeniletanon) must be noted, whose activity exceeds the activity of Phenobarbitalum and Midokalm in 1,23 and 1,27 times respectively on korazol model of seizures in rats. For some classes of 1,2,4-triaxole-3-thione 5-furanderivatives there were established structure–action patterns.
Chromato-mass-spectrometric assessment of volatile components for nettle (Urtica dioica L.)
Authors: Smoylovskaya G. P. 
Published: September 2019

The species of nettle (Urtica dioica) are used long ago as hemostaticum for hemorrhages of various genesis both in non-traditional and in official medicine. Besides, the extractions of nettle possess hypolipidemic, cholagogue, anti-inflammatory, spasmolytic, prostatoprotective, adaptogenic properties, etc. Biologic activity of the nettle (Urtica dioica) is conditioned by the presence of various vitamins, carotenoids, proteins, flavonoids, hydroxycinnamic and organic acids, β-cytosterol, volatile compounds and other components.
The aim of our study was to investigate the qualitative and quantitative composition of the volatile content of nettle.
The research has been done on aero-dried vegetable raw-material Urtica dioica L. (leaves), stocked in June 2014 in Zaporizhzhya region. Identification and assessment of a number for volatile components has been done on the chromatograph Agilent Technology 6890 N with mass-spectrometric detector 5973.
Approximately 20 components have been revealed in the leaves of Urtica dioica: hexahydrofarnesilacetate (165,19 mc/kg) and squalene (99,59 mc/kg) are predominated. Phytol, 2-methoxy-4-vinylphenol, nonacosane, etc. are presented in lesser number. The content of chrysanthenone, p-cymen-8-ol, verbenone, nerolidol, caryophyllene oxide, tricosane, tetracosane, heptacosane and untriacontane was insignificant (1,9% of the total amount of volatile components). Total number of volatile components in the leaves of Urtica dioica was 498,61 mc/mg. The research of qualitative composition and a number of volatile components in the leaves of Urtica dioica growing in Ukraine demonstrate expediency to carry out the further researches on the species Urtica dioica for using them in elaborating phytodrugs of complex action.
Daftar Isi Vol. 3 No. 2 2019
Authors: JSHP Jurnal 
Published: September 2019

Puji dan syukur kita panjatkan kehadirat Allah SWT, karena atas berkat dan rahmat-Nya Jurnal Sosial Humaniora dan Pendidikan (JSHP) Volume 3 Nomor 2 Tahun 2019 dapat diterbitkan oleh Pusat Penelitian dan Pengabdian kepada Masyarakat (P3M) Politeknik Negeri Balikpapan.JSHP diterbitkan secara berkala sebagai wadah publikasi hasil penelitian dan karya ilmiah dibidang Sosial, Humaniora dan Pendidikan Tinggi yang dilakukan oleh dosen dan peneliti baik internal Politeknik Negeri Balikpapan serta insan akademik dari perguruan tinggi lain.Dengan terbitnya JSHP ini secara berkala semoga dapat meningkatkan motivasi dan produktivitas dosen dan peneliti di Kota Balikpapan dan sekitarnya untuk lebih banyak menghasilkan karya-karya penelitian yang bermanfaat dan menjawab kebutuhan masyarakat. Disamping itu JSHP ini semoga dapat menjadi sumber referensi untuk kegiatan penelitian serta dapat memperkaya bahan ajar bagi kegiatan belajar mengajar di Kampus Politeknik Negeri Balikpapan dan kampus lainnya. Penerbitan JSHP Vol 3 No 2 2019 mengalami kemunduran terbit dikarenakan dalam proses penyempurnaan tampilan website dan proses review artikel yang baru selesai. Kedepan semoga lebih tepat waktu.Akhirnya redaksi JSHP mengucapkan selamat dan terimakasih pada para dosen/peneliti yang telah berkontribusi dalam penerbitan JSHP Vol 3 No 2 2019. Balikpapan, 10 September 2019 Hormat Kami Redaksi JSHP
Pengetahuan dan Sikap Lansia tentang Penggunaan Obat Tradisional Hipertensi
Authors: Awaluddin Awaluddin , Purwanto Purwanto 
Published: September 2019

The used of traditional medicines to decrease hypertension were increased. The used of them were influenced by knowledge and attitude. The purpose of this study was to known the correlation of knowledge and attitude of the elderly in use of the traditional medicine to reducing hypertension in Batang Tumu Health Center, District of Indragiri Hilir. This study was analytical withcross sectionaldesign. The population were all elderly who had hypertension as many as 143 respondent. The number of samples in this study were 59 respondents. The technique of sampling was purposive. Measuring instrument used was questionnairre. The results showed that elderly with well knowledge were 31 respondents (52.2%) and positive attitude were 38 respondents (64.4%). The chi square test results showed that there was a significant correlation between knowledge with the use of traditional medicine to reduce hypertension with p value 0.002<alpa 0.05. There was a significant correlation between elderly attitude with the use of traditional medicine to reduce hypertension with p value 0.004 <alpa 0.05. This result of study had implication to nursing that needed good knowledge and positive attitude for elderly so that can be use hypertension traditional medicine.
Magnitude of electric burns at a burn center in tertiary level hospital
Authors: Islam Md Tarikul , Rahman Mizanur , Nayeem SM Zulker , Uddin Md Farid 
Published: September 2019

Background: Burns are a public health problem throughout the world. Electrical injury is a major cause of burn injury which causes significant functional disability, disfigurement and mortality. In Bangladesh, the number of electrical injuries are increasing but they are typically underreported.
Aims: This study was conducted to analyze the epidemiological variables of electrical burn injuries and identify preventable measures through them in Khulna region of Bangladesh.
Methods: This descriptive study is a prospective analysis of patients suffering from electrical burns admitted at Burn and plastic surgery department from July 2017 to June 2018. The study population consists of 68 patients who sustained electrical injuries irrespective of age and time with cutaneous burns, admitted at this Center. Patients with electrocution but no electrical cutaneous burn injuries were excluded from this study.
Results: Majority were males (77.94%) of working age and injuries were work related (52.94%) of which 32.36% were construction workers. The primary cause in majority of the cases (57.35%) was accidental direct contact with electric wire followed by secondary contact with electrical power lines by metal rods and electrification of different metallic equipments (42.64%). Most of the patients admitted were high voltage electrical injuries (54.42%). Among them 16.17% had severe electrical burns and 2.94% had associated traumatic injuries. There was a delay in time of injury to hospital admission, 35.29% arrived at the emergency room 8 or more hours after the injury. Most (63.24%) of the patients underwent surgery, majority of which had moderate to severe burns. Length of hospital stay was 3-102 days. Two patients (2.94%) died during this study period due to renal failure and septicaemia.
Conclusion: Most of the electric burn patients acquired injury at working place and primary cause was direct or secondary contact with powerline. Immediate preventive measures should be taken to reduce the incidence of electric burns.
Bang Med J (Khulna) 2018; 51 : 29-34
LOS DERECHOS DE LA NATURALEZA EN LA CONSTITUCIÓN ECUATORIANA DEL 2008: ALCANCE, FUNDAMENTOS Y RELACIÓN CON LOS DERECHOS HUMANOS
Authors: Campaña Farith Simon 
Published: September 2019

El otorgamiento de derechos a la naturaleza (“la pachamama”) en la Constitución ecuatoriana del 2008 se ha presentado como una innovación trascendental en el mundo jurídico para la protección del planeta Tierra. Esta se explica como una confluencia de cosmovisiones distintas (la comprensión indígena sobre la naturaleza y la teoría occidental de la Gaia de James Lovelock) que dio paso a una comprensión de la relación ser humano-naturaleza, dejando atrás un antropocentrismo reflejo claro de la modernidad y ha dado paso al biocentrismo. Este trabajo explora las justificaciones que se han dado para ese reconocimiento, particularmente aquellas que aseguran que la cosmovisión indígena es la que llevó a esta declaración constitucional; la forma en que la jurisprudencia constitucional ecuatoriana ha tratado el tema y lasposibles relaciones que se dan con los derechos humanos.
Management of Rhegmatogenous Retinal detachment with Buckle Sclera and Cryoretinopexcy
Authors: Mutiara Ria , Amin Ramzi 
Published: September 2019

Introduction: Retinal detachment is divided into three categories. The most common type is the regmatogen retinal detachment (rhegmatogenous retinal detachment), which is the result of the tearing of the retinal lining. Actions can be Buckle Sclera, vitrectomy pars plana and pneumatic retinopexy. The purpose of this case report to reported Management of Rhegmatogenous Retinal detachment with Buckle Sclera and Cryoretinopexcy.
Method: A 58 years old man with chief complaint The left eye blurred like a curtain covered since 5 days,floaters (+), photopsia (+),headache (+), Patients never complain of lost vision suddenly before, eyeball pain is not there.History of trauma (+),On examination, the visual acuity 6/9 RE and 1/60 LE, anterior segment lens cloudy (+)nuclaer gr III, fundus photograph we found retinal contours of the blood vessels well, tear (+) is directed at 2-3 hours of superior-temporal and fovea reflex (-), B-scan ultrasound of the posterior segment the retina is not intact, Membran like lession detachment which attach to optic nerve.
Results: The Sclera buckles and cryoretinopexy were performed under general antesthesia. Visual acuity post-operative on left eye 2/60. subconjunctival bleeding (+), the fundus photographs retinal attach but the macular reflex is still negative. post-operative theraphy with topical steroid and antibiotic eye drops, oral antibiotic, and oral analgetic. follow up 1-month post-operative visual acuity 5/60 with fundus photograph obtained retina attach.
Conclusion: a diagnosis of retinal detachment can be found, with the discovery of fullthickness breaks or defects occurring from the retinal neurosensory, this break will allow the vitreous to enter the defect gap between the retinal neurosensory and RPE. Based on the clinical features of the posterior segment, the detachment area was found with the location of the Linchoff Rule 2 break based on the American Academy of Ophthalmology. The objective of operative therapy was to reattach the retinal portion of which one of them was buckle sclera and cryoretinopexcy.
PEMETAAN PARTISIPATIF KAMPUNG PESISIR KELURAHAN TALLO KOTA MAKASSAR
Authors: Fisu Amiruddin Akbar , Marzaman Liza Utama 
Published: September 2019

Warga kampung pesisi di Kelurahan Tallo memiliki masalah dalam bidang sanitasi dan membutuhkan bimbingan dalam pengelolaan prasarana sanitasi tersebut. Tingkat partisipasi warga boleh dikatakan masih sangat kurang. Hal ini disebabkan karena peran partisipasi tersebut telah diambil alih oleh stakeholder-stakeholder kampung, sehingga warga menjadi terbiasa untuk hanya menjadi penonton dari program-program yang masuk ke kampungnya. Kurangnya partisipasi warga, serta kurangnya pendampingan masyarakat yang memadai menjadikan warga cenderung apatis, sehingga sulit untuk mengimplementasikan program-program pembangunan masyarakat jangka panjang, dimana keikutsertaan dan semangat gotong-royong masyarakat lah yang menjadi modal utamanya. Melalui kegiatan pemetaan partisipatif ini, kami ingin mencoba menggugah kembali kesadaran warga tentang pentingnya kegotong-royongan dalam menyelesaikan masalah dalam kehidupan bermasyarakat.Â Dari dua kegiatan yang kami telah lakukan yaitu pemetaan partisipatif dan pengorganisasian warga, kami mengharapkan beberapa target luaran yang akan dicapai yang terbagi atas luaran yang bersifat fisik, dan non-fisik.
A CONCEPÇÃO DE PROFESSORES SOBRE SEXUALIDADE
Authors: Freitas Maria José Dias de , Brêtas José Roberto da Silva 
Published: September 2019

Trata-se de um estudo descritivo com abordagem qualitativa e produção dos dados por meio de Grupo Focal. Buscou-se conhecer as concepções e dificuldades de professoras de Creche, Educação Infantil e Ensino Fundamental I, sobre a sexualidade no ambiente escolar. A análise dos dados foi realizada mediante a análise de conteúdo temática, do tipo categorial, que produziu duas categorias temáticas. Os resultados apontaram dificuldades das professoras em relação à temática. A falta de conhecimento produz informações e crenças estereotipadas, representadas no cotidiano da escola em forma de preconceito e indiferença. O desconhecimento decorre de três fatores: formação deficiente sobre o tema, construções sócio-históricas e visão da sexualidade centrada no ponto de vista adulto. O estudo sinaliza questões importantes a serem incluídas na formação inicial e continuada de professores.
FATORES RELEVANTES NA INICIAÇÃO SEXUAL
Authors: Silva Vilma Maria , Amorim Rosemary de Jesus Machado , Barros Romualda Castro do Rêgo , Javorski Marly , Queiroga Bianca Arruda Manchester de , Andrade Rógerson Tenório de , Lima Luciane Soares de 
Published: September 2019

Na adolescência a sexualidade tem significado especial, já que o indivíduo inicia a consolidação da identidade sexual e atinge a capacidade reprodutiva. A primeira relação sexual acontece cada vez mais cedo e a vivência saudável do período de experimentação inerente à adolescência contribuirá para formação de adultos capazes de tomar decisões conscientes e planejadas ao longo da vida, evitando situações traumáticas. Este trabalho qualiquantitativo é resultado de dissertação com objetivo de conhecer as opiniões dos adolescentes de uma escola pública em relação a fatores relevantes para iniciação sexual. A população foi constituída de adolescentes entre 15 e 19 anos e a amostra foi composta por 61 adolescentes. Foi utilizada a técnica do Discurso do Sujeito Coletivo com o auxílio do Qualiquantisoftware. As categorias identificadas foram: práticas preventivas; sentimentos e parceria; estrutura pessoal, familiar e financeira; rede de apoio; protagonismo juvenil e gênero feminino: responsabilidade, desconhecimento e submissão. Embora este assunto seja muito abordado, muitos adolescentes não trazem as informações para seus contextos de vida. Recomenda-se que as famílias e as escolas priorizem espaços para discussão desse tema, além do acesso às políticas de saúde sexual e reprodutiva.
HISTÓRIA DA EDUCAÇÃO SEXUAL NO BRASIL
Authors: Bueno Rita Cássia Pereira , Ribeiro Paulo Rennes Marçal 
Published: September 2019

Este artigo traça um panorama da Educação Sexual no Brasil, apontando os principais marcos históricos e as iniciativas mais importantes que visaram a implantação da Educação Sexual no país. Inicia sua análise histórica nas primeiras décadas do século XX, centrando nos anos 1960 e seguintes. Os anos1940-1950 constituíram um período de vasta produção bibliográfica, os anos 1960 foram os anos das primeiras ações efetivas de Educação Sexual em escolas e os anos 1980 o período em que órgãos de governos municipais e estaduais desenvolveram projetos de Educação Sexual.