bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prospects of a Small-Block House Building within the Concept of the Automated Structure Construction of Residential Buildings
Authors: Kulikov A V , Baranov V A 
Published: June 2019

Abstract
This article represents conceptual research of the issues of automation of wall construction of multistoried buildings. Initially, the authors of the article reviewed key issues arising at realization of layer-by-layer wall construction method using building printers (so-called contour construction). According to the authors, the specified problems make significant limitations in the further development of contour construction method, since they have no simple solutions within this method. In other words, the method doesn’t allow to solve some specific technological issues related to the field of structural design. Authors proposed a concept of the automated small-block construction method, which allows to solve the listed issues, and also to reduce quantity of technological steps made directly on the building site. The concept borrows some practices of the existing contour construction methods (in particular, use of portal printers), by keeping unchanged the principle of small-block wall construction method. Thus the automation of the building of the walls concerns precisely the processes of preparation, delivery, and installation of small blocks in their specified position, and the associated technological processes (like wall decoration or channel making) decide due to complication of wall blocks structure. The authors of the article consider that the proposed small-block construction method will allow to optimize and accelerate processes of structure construction of residential buildings.
Longitudinal Walls Oscillations of an Annular Channel Filled with Pulsating Viscous Fluid
Authors: Kondratov D V , Popov V S , Popova A A 
Published: June 2019

Abstract
The mathematical model for longitudinal oscillations study of elastically fixed walls of an annular channel filled with a viscous fluid is reviewed. We assume that the channel walls are formed by two coaxial cylinders. These cylinders were elastically fixed at the edges and could make only longitudinal oscillations. The fluid motion in the channel takes place due to assigned pulsating pressure difference. The creeping liquid motion is studied and the hydrodynamic parameters distribution laws of the annular fluid layer as well as the motion laws of the channel walls are estimated. The steady-state harmonic oscillations regime is considered. Amplitude frequency characteristics of the annular channel walls are constructed.
CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction
Authors: Yeung Yiu To , Fan Suyu , Lu Bingbing , Yin Shuying , Yang Sen , Nie Wenna , Wang Meixian , Zhou Liting , Li Tiepeng , Li Xiang , Bode Ann M , Dong Zigang 
Published: June 2019

Abstract
The phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway is important in the regulation of cell proliferation through its production of phosphatidylinositol 3,4,5-triphosphate (PIP3). Activation of this pathway is frequently observed in human cancers, including non-small cell lung carcinoma. The PI3-K/Akt pathway is negatively regulated by the dual-specificity phosphatase and tensin homolog (PTEN) protein. PTEN acts as a direct antagonist of PI3-K by dephosphorylating PIP3. Studies have shown that PTEN phosphatase activity is inhibited by PREX2, a guanine nucleotide exchanger factor (GEF). Multiple studies revealed that CELF2, an RNA binding protein, cooperates synergistically with PTEN as a tumor suppressor in multiple cancers. However, the underlying mechanism as to how CELF2 enhances PTEN activity remains unclear. Here, we report that CELF2 interacts with PREX2 and reduces the association of PREX2 with PTEN. Consistent with this observation, PTEN phosphatase activity is upregulated with CELF2 overexpression. In addition, overexpression of CELF2 represses both Akt phosphorylation and cell proliferation only in the presence of PTEN. In an ex vivo study, CELF2 gene delivery could significantly inhibit patient-derived xenografts (PDX) tumor growth. To further investigate the clinical relevance of this finding, we analyzed 87 paired clinical lung adenocarcinoma samples and the results showed that CELF2 protein expression is downregulated in tumor tissues and associated with poor prognosis. The CELF2 gene is located on the chromosome 10p arm, a region frequently lost in human cancers, including breast invasive carcinoma, low-grade glioma and glioblastoma. Analysis of TCGA datasets showed that CELF2 expression is also associated with shorter patient survival time in all these cancers. Overall, our work suggests that CELF2 plays a novel role in PI3-K signaling by antagonizing the oncogenic effect of PREX2.
Parallel 3-D marine controlled-source electromagnetic modelling using high-order tetrahedral Nédélec elements
Authors: Castillo-Reyes Octavio , de la Puente Josep , García-Castillo Luis Emilio , Cela José María 
Published: June 2019

SUMMARY
We present a parallel and high-order Nédélec finite element solution for the marine controlled-source electromagnetic (CSEM) forward problem in 3-D media with isotropic conductivity. Our parallel Python code is implemented on unstructured tetrahedral meshes, which support multiple-scale structures and bathymetry for general marine 3-D CSEM modelling applications. Based on a primary/secondary field approach, we solve the diffusive form of Maxwell’s equations in the low-frequency domain. We investigate the accuracy and performance advantages of our new high-order algorithm against a low-order implementation proposed in our previous work. The numerical precision of our high-order method has been successfully verified by comparisons against previously published results that are relevant in terms of scale and geological properties. A convergence study confirms that high-order polynomials offer a better trade-off between accuracy and computation time. However, the optimum choice of the polynomial order depends on both the input model and the required accuracy as revealed by our tests. Also, we extend our adaptive-meshing strategy to high-order tetrahedral elements. Using adapted meshes to both physical parameters and high-order schemes, we are able to achieve a significant reduction in computational cost without sacrificing accuracy in the modelling. Furthermore, we demonstrate the excellent performance and quasi-linear scaling of our implementation in a state-of-the-art high-performance computing architecture.
Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1α expression1
Authors: Zhang Yong , Yu Bing , Yu Jie , Zheng Ping , Huang Zhiqing , Luo Yuheng , Luo Junqiu , Mao Xiangbing , Yan Honglin , He Jun , Chen Daiwen 
Published: June 2019

Abstract
The present study aimed to investigate the influence of dietary butyrate supplementation on muscle fiber-type composition and mitochondrial biogenesis of finishing pigs, and the underlying mechanisms. Thirty-two LY (Landrace × Yorkshire) growing pigs with BW of 64.9 ± 5.7 kg were randomly allotted to either control (basal diet) or butyrate diets (0.3% butyrate sodium). Compared with the control group, diet supplemented with butyrate tended to increase average daily gain (P < 0.10). Pigs fed butyrate diet had higher intramuscular fat content, marbling score and pH24 h, and lower shear force and L*24 h in longissimus thoracis (LT) muscle than that fed control diet (P < 0.05). Interestingly, supplemented with butyrate increased (P < 0.05) the mRNA level of myosin heavy chain I (MyHC-I) and the percentage of slow-fibers, and decreased (P < 0.05) the mRNA level of MyHC-IIb in LT muscle. Meanwhile, pigs in butyrate group had an increase in mitochondrial DNA (mtDNA) copy number and the mRNA levels of mtDNA-encoded genes (P < 0.05). Moreover, feeding butyrate diet increased PGC-1α (PPAR γ coactivator 1α) level, decreased miR-133a-3p level and increased its target gene level (TEAD1, TEA domain transcription factor 1), increased miR-208b and miR-499-5p levels and decreased their target genes levels (Sp3 and Sox6, specificity protein 3 and SRY-box containing gene 6; P < 0.05) in the LT muscle. Collectively, these findings suggested that butyrate promoted slow-twitch myofiber formation and mitochondrial biogenesis, and the molecular mechanism may be via upgrading specific microRNAs and PGC-1α expression, finally improving meat quality.
Effect of Temperature and Tissue Type on the Development of the Forensic Fly Chrysomya megacephala (Diptera: Calliphoridae)
Authors: Bambaradeniya Y Tharindu B , Karunaratne W A Inoka P , Tomberlin Jeffery K , Goonerathne Induwara , Kotakadeniya Rasika B , Magni Paola A 
Published: June 2019

Abstract
Chrysomya megacephala Fabricius is one of the most common myiasis-causing and carrion-feeding fly species in the tropics. This species has a worldwide distribution due to globalization and therefore is of critical importance to the public health sector and forensic investigations. Development studies carried worldwide show that Ch. megacephala reared at similar temperatures may require different amounts of time to complete their cycle of growth. The present study determined for the first time the life-history information of this species in Sri Lanka. Chrysomya megacephala colonies were reared on three different food sources (bovine muscle, swine muscle, and swine liver) considering the most common forensic entomology rearing mediums and the capability of Ch. megacephala to cause myiasis in cattle. Furthermore, colonies were reared at four temperature regimes representing several specific development conditions of this blowfly: 1) 20°C representing the estimation of the lower developmental threshold for this species in Sri Lanka; 2) 25 and 27°C representing typical room/environmental temperatures in Sri Lanka; and 3) 38°C as this is the typical living animal temperature, representing myiasis conditions. Results show that temperature significantly affected larval length and width over time; however, tissue type was not a significant factor. The fastest development was recorded at 38°C for immature feeding on bovine muscle (162.15 h), followed by those fed swine liver (184.15 h) and swine muscle (208.00 h). The calculated minimum temperature threshold for Ch. megacephala was 13°C. Data generated will be crucial for future forensic investigations involving living or deceased individuals colonized by this species.
Advantageous Feeding on Different Blood Meal Sources by the Chagas Disease Vector Triatoma barberi (Hemiptera: Reduviidae)
Authors: Martínez-Ibarra J A , Nogueda-Torres B , Meraz-Medina T , Diaz-Chavez R , Virgen-Cobian C J , Quirarte-Brambila M 
Published: June 2019

AbstractTriatominae bugs (Hemiptera: Reduviidae) are usually associated with different vertebrate species, upon which many of them feed. Yet how these different blood meal sources influence key biological parameters is rarely investigated for triatomines. To fill this knowledge gap, this study sought to determine the effect of a domestic rat species (Rattus norvegicus Berkenhout (Rodentia: Muridae)), a domestic mice species (Mus musculus L. (Rodentia: Muridae)), and chickens (Gallus gallus domesticus L. (Galliformes: Phasianidae)), as blood meal sources upon several biological parameters (development time, number of required blood meals to moult and feeding and defecation behaviors) of the Mexican major vector Triatoma barberi Usinger. The three studied cohorts’ development times were similar (325–338 d), but the number of required blood meals to moult (21), as well as the total mortality rate (26%), were both the highest in the cohort that fed on chickens. The longevity of females (186–190 d) was similar among the three studied cohorts, as was that of males. The median time elapsed between the presentation of a blood meal source and onset of feeding (10 min) was similar among the three studied cohorts, as were their feeding times and defecation patterns. Most of our studied parameters demonstrate how T. barberi can effectively take advantage of feeding on rodents as much as it does on hens. Those parameter results also show that T. barberi should be considered as a potential yet underappreciated vector in some areas, thus warranting a surveillance program of its current distribution area in Mexico.
Luminosity–duration relation of fast radio bursts
Authors: Hashimoto Tetsuya , Goto Tomotsugu , Wang Ting-Wen , Kim Seong Jin , Wu Yi-Han , Ho Chien-Chang 
Published: June 2019

Abstract
Nature of dark energy remains unknown. Especially, to constrain the time variability of the dark energy, a new, standardizable candle that can reach more distant Universe has been awaited. Here we propose a new distance measure using fast radio bursts (FRBs), which are a new emerging population of ∼ ms time-scale radio bursts that can reach high-z in quantity. We show an empirical positive correlation between the time-integrated luminosity (Lν) and rest-frame intrinsic duration (wint, rest) of FRBs. The Lν−wint, rest correlation is with a weak strength but statistically very significant, i.e. Pearson coefficient is ∼ 0.5 with P value of ∼0.038, despite the smallness of the current sample. This correlation can be used to measure intrinsic luminosity of FRBs from the observed wint, rest. By comparing the luminosity with observed flux, we measure luminosity distances to FRBs, and thereby construct the Hubble diagram. This FRB cosmology with the Lν−wint, rest relation has several advantages over SNe Ia, Gamma-Ray Burst (GRB), and well-known FRB dispersion measure (DM)-z cosmology; (i) access to higher redshift Universe beyond the SNe Ia, (ii) high event rate that is ∼3 orders of magnitude more frequent than GRBs, and (iii) it is free from the uncertainty from intergalactic electron density models, i.e. we can remove the largest uncertainty in the well-debated DM-z cosmology of FRB. Our simulation suggests that the Lν−wint, rest relation provides us with useful constraints on the time variability of the dark energy when the next-generation radio telescopes start to find FRBs in quantity.
Spectral energy distribution of the first galaxies: contribution from pre-main-sequence stars
Authors: Mitani Hiroto , Yoshida Naoki , Omukai Kazuyuki , Hosokawa Takashi 
Published: June 2019

ABSTRACT
One of the major goals of next-generation space-borne and ground-based telescopes is to detect and characterize the first galaxies that were in place in the first few hundred million years after the big bang. We study the spectral energy distribution (SED) of the first galaxies and discuss the prospects for detection and identification. We consider very young star-forming galaxies at z = 15 and incorporate the contribution from pre-main-sequence (PMS) stars. Unlike in the present-day galaxies, primordial protostars are not embedded in dusty gas clouds, and hence the light from them can be visible at a wide range of wavelengths. We use mesa to follow the PMS evolution and use the BT-Settl model to calculate the SED of individual PMS stars. We show that PMS stars contribute to boost the flux in the mid-infrared, and that the galaxy SED at very early evolutionary phases is overall redder than at later phases. The infrared flux contribution is comparable to that caused by emission lines powered by massive stars. We argue that the contribution from PMS stars is important for characterizing young galaxies in the early Universe and also for target selection with future deep galaxy surveys.
Toxin–antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA–KacT complex
Authors: Qian Hongliang , Yu Hao , Li Peifei , Zhu E , Yao Qingqing , Tai Cui , Deng Zixin , Gerdes Kenn , He Xinyi , Gan Jianhua , Ou Hong-Yu 
Published: June 2019

AbstractBacterial toxin–antitoxin pairs play important roles in bacterial multidrug tolerance. Gcn5-related N-acetyltransferase (GNAT) toxins inhibit translation by acetylation of aminoacyl-tRNAs and are counteracted by direct contacts with cognate ribbon–helix–helix (RHH) antitoxins. Our previous analysis showed that the GNAT toxin KacT and RHH antitoxin KacA of Klebsiella pneumoniae form a heterohexamer in solution and that the complex interacts with the cognate promoter DNA, resulting in negative autoregulation of kacAT transcription. Here, we present the crystal structure of DNA-bound KacAT complex at 2.2 Å resolution. The crystal structure revealed the formation of a unique heterohexamer, KacT–KacA2–KacA2–KacT. The direct interaction of KacA and KacT involves a unique W-shaped structure with the two KacT molecules at opposite ends. Inhibition of KacT is achieved by the binding of four KacA proteins that preclude the formation of an active KacT dimer. The kacAT operon is auto-regulated and we present an experimentally supported molecular model proposing that the KacT:KacA ratio controls kacAT transcription by conditional cooperativity. These results yield a profound understanding of how transcription GNAT–RHH pairs are regulated.
Fractures and their sequelae in non-dialysis-dependent chronic kidney disease: the Stockholm CREAtinine Measurement project
Authors: Runesson Björn , Trevisan Marco , Iseri Ken , Qureshi Abdul Rashid , Lindholm Bengt , Barany Peter , Elinder Carl Gustaf , Carrero Juan Jesus 
Published: June 2019

Abstract

Introduction
People undergoing maintenance dialysis are at high risk for fractures, but less is known about fracture incidence and associated outcomes in earlier stages of chronic kidney disease (CKD).

Methods
We conducted an observational analysis from the Stockholm Creatinine Measurement project, a Swedish health care utilization cohort during 2006–11. We identified all adults with confirmed CKD Stages 3–5 and no documented history of fractures and extracted information on comorbid history, ongoing medication, cardiovascular events and death. We studied incidence rates of fractures (overall and by location), with the estimated glomerular filtration rate (eGFR) as time-dependent exposure. We then studied hazard ratios [HRs and 95% confidence intervals (CIs)] for the events of death and major adverse cardiac events (MACE) using Cox regression with fracture as time-varying exposure.

Results
We identified 68 764 individuals with confirmed CKD (mean age 79 years, 56% women). During a median follow-up of 2.7 years, 9219 fractures occurred, of which 3105 were hip fractures. A more severe CKD stage was associated with a higher risk of fractures, particularly hip fractures: compared with CKD Stage 3a, the adjusted HR was 1.10 (95% CI 1.02–1.19), 1.32 (1.17–1.49) and 2.47 (1.94–3.15) for CKD Stage 3b, 4 and 5, respectively. Spline curves suggested a linear association with fracture risk with an eGFR &lt;30 mL/min/1.73 m2. Compared with non-fracture periods, incident fracture was associated with a 4-fold increased mortality within 90 days [HR 4.21 (95% CI 3.95–4.49)]. The risk remained elevated beyond 90 days [HR 1.47 (95% CI 1.40–1.54)] and was stronger after hip fractures. Post-fracture MACE risk was also highest in the first 90 days [HR 4.02 (95% CI 3.73–4.33)], particularly after hip fractures, and persisted beyond 90 days [HR 1.20 (95% CI 1.10–1.30)].

Conclusion
Our findings highlight the commonness of fractures and the increased risk for subsequent adverse outcomes in CKD patients. These results may inform clinical decisions regarding post-fracture clinical surveillance and fracture prevention strategies.
Planning the Presentation of Topics in Piano Pedagogy
Authors: Crappell Courtney 
Published: June 2019

Abstract
Chapter 2, “Planning the Presentation of Topics in Piano Pedagogy,” begins with an introduction to the topics commonly included in piano pedagogy courses. It will be most useful to pedagogy teachers who are designing, or redesigning, pedagogy curricula. Topics in piano pedagogy are framed within the following four large categories: (1) knowledge, (2) skills, (3) business concerns, and (4) research and perspectives in piano pedagogy. After an introduction to the topics within each category, it includes suggestions for how pedagogy teachers can adjust the scope of topics within their curriculum plan and also offers suggestions for planning course assignments.
“Mayhem”
Authors: Kolker Robert P. , Abrams Nathan 
Published: June 2019

Abstract
Stanley Kubrick died shortly after screening his final cut of Eyes Wide Shut. This chapter clears up the debate of whether the film was “unfinished.” Kubrick had indeed left undone many details of the editing of the film, the choice of whether or not to use voiceover narration that had been written, and the completion of the music score. The final decision to create digital figures to black out some of the orgy scenes had to be made to avoid receiving an NC-17 rating. Decisions about marketing and distribution, which Kubrick used to handle himself, also had to be taken.
Identities
Authors: Halkitis Perry N. 
Published: June 2019

Abstract
Gay men hold multiple identities, which define who they are and which shape their experiences of coming out. The chapter introduces the fifteen men of varying ages, races, ethnicities, and places of birth, whose life narratives provide the means for exploring the coming out process within and across generations and of the social, emotional, and behavioral conditions that have defined the lives of gay men. Five gay men who emerged into adolescence in the late 1950s, 1960s, and early 1970s constitute the Stonewall Generation; those who came of age in the late 1970s through the early 1990s are defined as members of the AIDS Generation; and those emerging into adulthood after the turn of the century belong to the Queer Generation. Each of the fifteen men is introduced in relation to his earliest memories of what would prove to be his gay identity and in the social-political context of the time.
Pedagogical Experiments in the Brazilian Countryside
Authors: Tarlau Rebecca 
Published: June 2019

Abstract
Chapter 1 analyzes the pedagogical experiments that MST activists developed in the Brazilian countryside in the 1980s and 1990s. In the early 1980s these educational experiments were largely isolated initiatives in dozens of different camps and settlements. There was room to experiment with pedagogical alternatives even under a dictatorship, partially due to the lack of state presence in these rural areas. In 1987, the MST leadership made education an official concern of the movement and founded the national MST education sector. Then, in the 1990s, MST leaders refined their educational proposal through their own teacher training programs, which became spaces for pedagogical experimentation and the prefiguration of alternative social and political values. These experiments took place under a conservative and antagonistic national government. In 1997, the MST published its first national educational manifesto, summarizing the different components of its educational approach.
From the Pedagogy of the MST to Educação do Campo
Authors: Tarlau Rebecca 
Published: June 2019

Abstract
Chapter 3 shows how the institutionalization of movement goals can sometimes look like a process of social movement absorption. In the late 1990s and early 2000s, the MST’s local educational practices in areas of agrarian reform evolved into a national proposal for an alternative educational approach in the entire Brazilian countryside. This proposal, which became known as Educação do Campo (Education of the Countryside), was explicitly linked to an alternative vision for rural development. Between 2004 and 2012 this educational proposal was implemented in the Ministry of Education (MEC) through several laws, an office, and a series of programs. However, the MEC’s hierarchical organization, focus on best practices, and need to rapidly expand its educational programs undermined the MST’s ability to participate—even with a federal government historically aligned with the movement. During this period, agribusiness groups also began to embrace Educação do Campo, leading to a watering down of the original proposal.