bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twin-Control Evaluation in Industrial Environment: Aerospace Use Case
Authors: Armendia Mikel , Ghassempouri Mani , Gil Guillermo , Mozas Carlos , Sanchez Jose A. , Cugnon Frédéric , Berglind Luke , Peysson Flavien , Fuertjes Tobias 
Published: January 2019

AbstractMore and more ICT applications appear in both market and research world, but few of them are applied under industrial conditions. One of the highlights of Twin-Control project is the validation of the different features in industrial environments. To do that, two validation scenarios, with very different requirements were defined. In this chapter, the evaluation of Twin-Control in an aerospace use case is presented. The evaluation consists in the presentation of the different implementations and the obtained results, as well as the impact caused by them in the end-users. This document shows the benefits of the application of Twin-Control in such a demanding sector like aerospace.
Twin-Control Approach
Authors: Armendia Mikel , Alzaga Aitor , Peysson Flavien , Euhus Dirk 
Published: January 2019

AbstractTwin-Control (http://twincontrol.eu/) is a new concept for machine tool and machining process performance optimization. It is based on a new simulation model that integrates the different aspects that affect machine tool and machining performance. This holistic approach allows a better estimation of machining performance than single-featured simulation packages, including lifecycle concepts like energy consumption and end-of-life components. This theoretical representation of the machine is complemented with real process data by the monitoring of the most important variables of the machining process and machine condition. This monitored information, combined with the developed models, is used at machine level to perform model-based control actions and/or warn about damaged components of the machine tool. In addition, a fleet-level data management system is used for a proper health management and optimizes the maintenance actions on the machine tools.
Modelling of Machining Processes
Authors: Berglind Luke , Ozturk Erdem 
Published: January 2019

AbstractThe Twin-Control product takes a holistic approach to modelling and simulation of machining processes, incorporating machine controller, machine structure, part program, part geometry, and process forces and dynamics into a single system. The focus of this chapter is on the process models used to simulate cutting forces, torques, form error, and tool dynamics throughout a part program. These predictions provide process planners with valuable information about an operation before it is executed on machine, allowing for potential issues to be identified and reduced or eliminated before the first part is produced.
Behaviours Indicators of Machine Tools
Authors: Peysson Flavien , Leon David , Lafuste Quentin , Armendia Mikel , Mutilba Unai , Guruceta Enrique , Kortaberria Gorka 
Published: January 2019

AbstractKnowledge of machine tool behaviour is a key element to improve production, quality and availability as behaviour indicators represent or give an idea of the real state of the machine. Indeed, real conditions can be used to update simulation models’ parameters, detect or anticipate quality fault on workpiece, and to estimate damage state of machine components such as axis and spindle. Behaviour indicators extraction is based on the analysis of specific and known moves or actions of the machine tools. Two kinds of approaches to build these indicators are discussed in this chapter.
Non-intrusive Load Monitoring on Component Level of a Machine Tool Using a Kalman Filter-Based Disaggregation Approach
Authors: Sossenheimer Johannes , Weber Thomas , Flum Dominik , Panten Niklas , Abele Eberhard , Fuertjes Tobias 
Published: January 2019

AbstractCollecting high-quality data points in the production process and using them to optimize the process are becoming increasingly important in the age of Industry 4.0. Measured energy and power data enable benchmarking and condition monitoring applications based on insightful energy performance indicators. As reliable measurement concepts require high investments and are accompanied by uncertain amortization periods, the development of new and more low-cost alternatives is essential. The following chapter will illustrate a cost-effective monitoring approach for industrial production machines on component level that can be applied to a wide range of machines. This is based on an algorithm that calculates the energy consumption from the aggregated power consumption and the control signals of the components. Cost and time-intensive sensor installations can thus be avoided. The data points obtained are then used to derive indicators that are able to identify energy wastage on component level. For this reason, the algorithm is implemented as a plug-in on an existing process control system. To ensure robustness against measurement uncertainties and distorting noise, a Kalman filter forms the basis of the algorithm. The capabilities of the proposed approach are demonstrated on a laboratory machine tool.
Consequences of Intimate Partner Violence
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractIt has been well documented in a host of studies that partner violence leads to many and various consequences for victims. Our study shows that self-reproach, shame of being a victim of violence and social anxiety seem to be universal, rather than gendered, phenomena among people who experience violence from those who are close to them. Those men who have lived in violent relationships have taken time to recognise and process the violence to which they have been subjected.
Men Who Are Subjected to Sexual Abuse
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractThis chapter is based on interviews with ten men who have sought help for sexual abuse. Most of these men have additionally experienced other forms of physical and psychological violence, as well as childhood neglect. Their experiences with these various forms of violence are described here in detail, as are the differing consequences these have had for the men involved.
Experience with Support Agencies
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractThis chapter illuminates men’s experiences with support agencies. First, we investigate men’s help-seeking and their perception of the help they require. We highlight men’s experiences with family counselling services before focusing on men’s experiences of the services offered at crisis centres and at centres against incest and sexual abuse. Several of the men express the feeling that these centres have saved their lives. However, men find it problematic that women and men are kept separate in crisis centres and suggest it detracts from the service offered to them. We conclude the chapter with concrete proposals for action.
“Firm Outlines and Hard Muscles Immortalised”: Ancient Statuary and E.P. Warren’s “Uranian Ideal”
Authors: Grove Jen 
Published: January 2019

AbstractThis chapter examines the role of ancient sculpture in the homoerotic ideals and real-life relationships of collector Edward Perry Warren in the late nineteenth and early twentieth century. The classical male nude in particular facilitated for Warren the establishment of models of virile masculinity and age-differentiated male-male attachments, as well as their wider dissemination through the provision of material to international museums. He saw certain styles of ancient art as embodying specific ancient values which could challenge contemporary heteronormativity, but also associations between homosexuality, effeminacy and aestheticism, and could confront emerging political ideas around gender equality.
Global Disparities in Breast Cancer Genetics Testing, Counselling and Management
Authors: Yip C. H. , Evans D. G. , Agarwal G. , Buccimazza I. , Kwong A. , Morant R. , Prakash I. , Song C. Y. , Taib N. A. , Tausch C. , Ung O. , Meterissian S. 
Published: January 2019

AbstractHereditary breast cancers, mainly due to BRCA1 and BRCA2 mutations, account for only 5–10% of this disease. The threshold for genetic testing is a 10% likelihood of detecting a mutation, as determined by validated models such as BOADICEA and Manchester Scoring System. A 90–95% reduction in breast cancer risk can be achieved with bilateral risk‐reducing mastectomy in unaffected BRCA mutation carriers. In patients with BRCA‐associated breast cancer, there is a 40% risk of contralateral breast cancer and hence risk‐reducing contralateral mastectomy is recommended, which can be performed simultaneously with surgery for unilateral breast cancer. Other options for risk management include surveillance by mammogram and breast magnetic resonance imaging, and chemoprevention with hormonal agents. With the advent of next‐generation sequencing and development of multigene panel testing, the cost and time taken for genetic testing have reduced, making it possible for treatment‐focused genetic testing. There are also drugs such as the PARP inhibitors that specifically target the BRCA mutation. Risk management multidisciplinary clinics are designed to quantify risk, and offer advice on preventative strategies. However, such services are only possible in high‐income settings. In low‐resource settings, the prohibitive cost of testing and the lack of genetic counsellors are major barriers to setting up a breast cancer genetics service. Family history is often not well documented because of the stigma associated with cancer. Breast cancer genetics services remain an unmet need in low‐ and middle‐income countries, where the priority is to optimise access to quality treatment.
Trends in the Nature and Management of Serious Abdominal Trauma
Authors: Ferrah Noha , Cameron Peter , Gabbe Belinda , Fitzgerald Mark , Martin Kate , Beck Ben 
Published: January 2019

AbstractBackgroundThere have been recommendations for increased non‐operative management (NOM) of abdominal trauma in adults. To assess the impact of this trend and changes in the epidemiology of trauma, we examined the management of serious abdominal injuries and mortality, in Victorian major trauma patients 16 years or older, between 2007 and 2016.MethodsUsing data from the population‐based Victorian Trauma Registry, characteristics of patients who underwent laparotomy, embolisation, laparotomy and embolisation, or NOM, were compared with the Chi‐square test. Poisson regression was used to determine whether the incidence of serious abdominal injury changed over time. Temporal trends in the management of abdominal injury and in‐hospital mortality were analysed using, respectively, the Chi‐square test for trend, and multivariable logistic regression.ResultsOf 2385 patients with serious abdominal injuries, 69% (n = 1649) had an intervention; predominantly a laparotomy (n = 1166). The proportion undergoing laparotomy decreased from 60% in 2007 to 44% in 2016 (p < 0.001), whilst embolisation increased from 6 to 20% (p < 0.001). Population‐adjusted incidence of abdominal injury increased 1.6% per year (IRR 1.016, 95% CI 1.002–1.031; p < 0.024), predominantly in people aged 65 years and over (4.6% per year). Adjusted odds of in‐hospital mortality declined 6.0% per year (adjusted odds ratio 0.94; 95% CI 0.89, 1.00; p = 0.04).ConclusionsWhilst the incidence of major abdominal trauma increased during the study period, there was a reduction in the proportion of patients managed with laparotomy and reduction in the adjusted odds of in‐hospital mortality. Older patients, for whom management is influenced by the complex interplay of frailty and co‐morbidities, had lower laparotomy rates.
New voyages to explore the natural product galaxy
Authors: Mouncey Nigel J , Otani Hiroshi , Udwary Daniel , Yoshikuni Yasuo 
Published: January 2019

Abstract
Natural products are a large family of diverse and complex chemical molecules that have roles in both primary and secondary metabolism, and over 210,000 natural products have been described. Secondary metabolite natural products are of high commercial and societal value with therapeutic uses as antibiotics, antifungals, antitumor and antiparasitic products and in agriculture as products for crop protection and animal health. There is a resurgence of activity in exploring natural products for a wide range of applications, due to not only increasing antibiotic resistance, but the advent of next-generation genome sequencing and new technologies to interrogate and investigate natural product biosynthesis. Genome mining has revealed a previously undiscovered richness of biosynthetic potential in novel biosynthetic gene clusters for natural products. Complementing these computational processes are new experimental platforms that are being developed and deployed to access new natural products.
Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL
Authors: Wenski Sebastian L , Kolbert Diana , Grammbitter Gina L C , Bode Helge B 
Published: January 2019

Abstract
Fabclavines, unusual peptide–polyketide–polyamine hybrids, show broad-spectrum bioactivity against a variety of different organism like Gram-positive and -negative bacteria, fungi and protozoa. We elucidated the biosynthesis of these NRPS–PKS hybrids in Xenorhabdus szentirmaii by deletion of most genes encoded in the fabclavine BGC and subsequent analysis of produced fabclavine or polyamine intermediates. Thereby, we identified shortened fabclavines similar to the bioactive zeamines. Furthermore, we analyzed the thioester reductase FclG and the free-standing condensation domain-like protein FclL in detail and observed low substrate specificity for both enzymes.
Influences of Material Aspirations on Migration
Authors: Thornton Arland , Williams Nathalie E. , Bhandari Prem , Young-DeMarco Linda , Sun Cathy , Swindle Jeffrey , Hughes Christina , Xie Yu 
Published: January 2019

Abstract
In this article, we investigate the influences of material aspirations on migration in Nepal, positing that material aspirations may have important influences on decisions to migrate and where to locate. We discuss a theoretical model explaining how these aspirations might be key influences in the migration decision. Using detailed continuous migration histories from the 2008–2012 Chitwan Valley Family Study, we estimate logistic and alternative-specific conditional logit models to examine how material aspirations in Nepal influence migration rates and destinations. Our empirical analyses provide strong evidence that material aspirations have large effects on overall rates of migration and affect destination-specific migration rates, particularly for relatively wealthy Western and Asian destinations. We also show an interaction effect between material aspirations and destination-specific expected earnings in influencing people’s migration choices. It is the people with high aspirations who migrate to destinations with high earning potentials.
Dropping slender-body theory into the mud
Authors: Spagnolie S. E. 
Published: January 2019

The equations describing classical viscous fluid flow are notoriously challenging to solve, even approximately, when the flow is host to one or many immersed bodies. When an immersed body is slender, the smallness of its aspect ratio can sometimes be used as a basis for a ‘slender-body theory’ describing its interaction with the surrounding environment. If the fluid is complex, however, such theories are generally invalid and efforts to understand the dynamics of immersed bodies are almost entirely numerical in nature. In a valiant effort, Hewitt & Balmforth (J. Fluid Mech., vol. 856, 2018, pp. 870–897) have unearthed a theory to describe the motion of slender bodies in a viscoplastic fluid, ‘fluids’ such as mud or toothpaste which can be coaxed to flow, but only with a sufficiently large amount of forcing. Mathematical theories for some tremendously complicated physical systems may now be within reach.
A rarefied gas flow around a rotating sphere: diverging profiles of gradients of macroscopic quantities
Authors: Taguchi Satoshi , Saito Kazuyuki , Takata Shigeru 
Published: January 2019

The steady behaviour of a rarefied gas around a rotating sphere is studied numerically on the basis of the linearised ellipsoidal statistical model of the Boltzmann equation, also known as the ES model, and the Maxwell diffuse–specular boundary condition. It is demonstrated numerically that the normal derivative of the circumferential component of the flow velocity and that of the heat flux diverge on the boundary with a rate

$s^{-1/2}$

, where

$s$

is the normal distance from the boundary. Further, it is demonstrated that the diverging term is proportional to the magnitude of the jump discontinuity of the velocity distribution function on the boundary, which originates from the mismatch of the incoming and outgoing data on the boundary. The moment of force exerted on the sphere is also obtained for a wide range of the Knudsen number and for various values of the accommodation coefficient.
Transition to the ultimate regime in a radiatively driven convection experiment
Authors: Bouillaut Vincent , Lepot Simon , Aumaître Sébastien , Gallet Basile 
Published: January 2019

We report on the transition between two regimes of heat transport in a radiatively driven convection experiment, where a fluid gets heated up within a tunable heating length $\ell$ in the vicinity of the bottom of the tank. The first regime is similar to that observed in standard Rayleigh–Bénard experiments, the Nusselt number $Nu$ being related to the Rayleigh number $Ra$ through the power law $Nu\sim Ra^{1/3}$. The second regime corresponds to the ‘ultimate’ or mixing-length scaling regime of thermal convection, where $Nu$ varies as the square root of $Ra$. Evidence for these two scaling regimes has been reported in Lepot et al. (Proc. Natl Acad. Sci. USA, vol. 115, 2018, pp. 8937–8941), and we now study in detail how the system transitions from one to the other. We propose a simple model describing radiatively driven convection in the mixing-length regime. It leads to the scaling relation $Nu\sim (\ell /H)Pr^{1/2}Ra^{1/2}$, where $H$ is the height of the cell and $Pr$ is the Prandtl number, thereby allowing us to deduce the values of $Ra$ and $Nu$ at which the system transitions from one regime to the other. These predictions are confirmed by the experimental data gathered at various $Ra$ and $\ell$. We conclude by showing that boundary layer corrections can persistently modify the Prandtl number dependence of $Nu$ at large $Ra$, for $Pr\gtrsim 1$.
From Buddha Bones to Bo Trees: Nehruvian India, Buddhism, and the poetics of power, 1947–1956
Authors: OBER DOUGLAS F. 
Published: January 2019

AbstractIn the first decade after Indian independence in 1947, the secular Indian state projected a vision of itself as being guided by universal ethics rooted in the nation's ancient Buddhist past. From the circulation of Buddhist relics in distant lands to the reinvention and incorporation of Buddhist symbols in contemporary state regalia, the government sponsored a wide variety of programmes in the name of world peace, Pan-Asian unity, and enlightened democratic values that promoted Buddhism both within India and across Asia. This more than decades-long effort was entirely the outcome of the political and social visions of India's first prime minister Jawaharlal Nehru and key members of his cabinet. In its most concise formulation, this Nehruvian-style Buddhism consisted of a two-pronged approach, one concerning the uses of Buddhism in the domestic sphere—that is, for domestic consumption by citizens of the new nation—and one concerning the uses of Buddhism as an instrument of foreign policy. At the heart of these projects was the dual effort to integrate a diverse South Asian populace into a wider national consciousness and yield influence among the post-colonial order in Asia. This article details the strategies and ideologies that Nehru and his cabinet employed vis-à-vis Buddhism from the mid-1940s to late 1950s when their Buddhist statecraft began to unravel due to geopolitical crises and the mass conversions of Ambedkarite Dalits. After tracing these developments, the article briefly considers the continued relevance of the Nehruvian engagement with Buddhism as it relates to twenty-first century Indian affairs.
Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone
Authors: Wolke Selina A. , Mehta Mitul A. , O'Daly Owen , Zelaya Fernando , Zahreddine Nada , Keren Hanna , O'Callaghan Georgia , Young Allan H. , Leibenluft Ellen , Pine Daniel S. , Stringaris Argyris 
Published: January 2019

AbstractBackgroundAberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D2 antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression.MethodsWe recruited 43 medication-naïve subjects across the range of depression severity (Beck's Depression Inventory-II score range: 0–43), including healthy volunteers, as well as people meeting full-criteria for major depressive disorder. In a double-blind placebo-controlled cross-over design, all subjects received either placebo or lurasidone (20 mg) across two visits separated by 1 week. Functional magnetic resonance imaging with the Monetary Incentive Delay (MID) task assessed reward functions via neural responses during anticipation and receipt of gains and losses. Arterial spin labelling measured cerebral blood flow (CBF) at rest.ResultsLurasidone altered fronto-striatal activity during anticipation and outcome phases of the MID task. A significant three-way Medication-by-Depression severity-by-Outcome interaction emerged in the anterior cingulate cortex (ACC) after correction for multiple comparisons. Follow-up analyses revealed significantly higher ACC activation to losses in high- v. low depression participants in the placebo condition, with a normalisation by lurasidone. This effect could not be accounted for by shifts in resting CBF.ConclusionsLurasidone acutely normalises reward processing signals in individuals with depressive symptoms. Lurasidone's antidepressant effects may arise from reducing responses to penalty outcomes in individuals with depressive symptoms.