bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaboration strategies for bridging health, behavioral health, and social services in California's Medi‐Cal Whole Person Care Pilot Program
Authors: Chuang Emmeline , Ross Rachel , Safaeinili Nadia , Haley Leigh Ann , O'Masta Brenna , Pourat Nadereh 
Published: December 2024

AbstractObjectiveTo identify collaboration strategies used to integrate health, behavioral health, and social services for Medicaid members in California's Medi‐Cal Whole Person Care Pilot program (WPC).Data Sources and Study SettingWPC was a social care intervention implemented to identify and address eligible members' health, behavioral health, and social needs. Data included semi‐structured key informant interviews conducted in 2018–2019 (n = 221) and 2021 (n = 167); pilot‐level surveys; whole‐network surveys of 507 organizations in all 25 pilots participating in WPC; and documents submitted by pilots to the state. Pilots served a total of 247,887 unique members between 2017 and 2021, the majority of whom were non‐white (72%) and over half of whom experienced homelessness.Study Design/Data CollectionData were collected as part of the statewide evaluation of WPC. We analyzed qualitative data to examine strategies used by pilots to integrate care, network data to identify pilots that improved cross‐sector collaboration (i.e., strengthened density or multiplexity of cross‐sector ties) following WPC implementation, and comparative case analysis to identify strategies that differentiated pilots that improved collaboration from those that did not.Principal FindingsPilots used multiple strategies to facilitate the integration of care. Network analyses identified 10 pilots that significantly improved either density or multiplexity of cross‐sector ties, and one pilot with high cross‐sector collaboration prior to WPC. Compared to pilots that did not improve cross‐sector collaboration, these pilots meaningfully engaged partners in program design and implementation, used braided funds, and leveraged WPC to support broader systems change. These pilots also reported fewer challenges in developing and managing contractual relationships and ensuring meaningful use of data‐sharing infrastructure by frontline staff responsible for care coordination.ConclusionsData sharing is necessary but not sufficient for systems alignment. Collaboration strategies focused on addressing financial barriers to integration and strengthening normative and interpersonal integration are also needed.
Business strategy and CEO pay duration
Authors: Gu Zhenjiang , Ding Rong , Ding Wenhong , Yu Yangxin 
Published: December 2024

AbstractIn this study, we investigate the effect of firm's business strategy on an important feature of chief executive officer (CEO) incentive compensation – the pay duration. Drawing on archival data collected from a large sample of US listed firms, we find that firms following a prospector strategy grant longer‐duration compensation to their CEOs than firms following a defender strategy. We further show that this effect of business strategy on pay duration is more pronounced for firms with higher information asymmetry and firms managed by CEOs with higher revealed ability. Our results are robust to alternative business strategy measures, an entropy balancing approach, alternative fixed‐effects models and an alternative pay duration measure that excludes performance‐vesting grants. Overall, the findings are consistent with prospector firms using longer pay duration to extend managers' investment horizon and to retain managerial talent.
The influence of corpus luteum and first‐wave dominant follicle location on conception rate after artificial insemination in Holstein cattle
Authors: Ho Thomas Chia‐Tang , Kubo Tomoaki , Aoki Akiko , Ichikawa Yuki , Uruma Hideyuki , Kawamoto Yuka , Tamura Yoji , Kojima Shusuke , Matsuo Mami , Koyama Keisuke 
Published: December 2024

AbstractThe influence of post‐ovulatory corpus luteum (CL) and first‐wave dominant follicle (1DF) location on pregnancy establishment in cattle remains controversial. This study aimed to reveal the relationship between CL and 1DF positioning, pregnancy outcomes, and blood steroid hormone levels following artificial insemination (AI) in Holstein cattle. Data from heifers (n = 163) and cows (n = 69) with optimally timed AI, defined as ovulation within 24 h post‐AI, were analyzed to determine associations between CL (left/right ovary) and 1DF (ipsilateral/contralateral to CL) locations and conception rates. Plasma progesterone (P4) and estradiol‐17β (E2) concentrations were measured five days post‐insemination. In heifers, neither CL (p = 0.24) nor 1DF location (p = 0.44) affected conception rates. Cows with left‐sided CL tended to have higher conception rates than those with right‐sided CL (p = 0.08). Relative 1DF location did not affect conception in cows. The location of CL and 1DF did not affect plasma P4 and E2 concentrations or the ratio of plasma E2 to P4 in heifers or cows. These findings suggest a trend towards improved conception rates in cows with CL located on the left ovary post‐AI, regardless of 1DF location. The mechanism should not be associated with systemic ovarian hormones.
Investigation of corticosteroid levels in the hairs of female Holstein calves
Authors: Fushuku Hiroki , Matsunaga Nobuyoshi 
Published: December 2024

AbstractThis study was designed to investigate the degree of long‐term effects by measuring cortisol and aldosterone concentrations in the growing hair including lipid which is absorbed from the blood of six female Holstein calves by enzyme‐linked immunosorbent assay (ELISA). The total number of calves used was 18 (three seasons). Three comparative factors were used: region (back and chest), hair color (black and white), and season (summer, winter, and spring). The hair cortisol of the back region (white color) was higher than the other region and color (p < 0.05). The measured value in the spring season (back region) was significantly higher than that in the summer (chest region) (p < 0.05). Although there has been no report on the hair aldosterone until now, it was possible to measure the concentration in the present study. The hair aldosterone of the back region was higher than the chest region (p < 0.01), and the white hair color was higher than the black hair color (p < 0.05). The measured value in the spring season was also significantly higher than that in the summer season and the winter season (p < 0.01). This result suggested the changes are affected by the hair region factor, the hair color factor, and the changing meteorological conditions.
Heterogeneous experiences of people with bipolar disorder during euthymia: Profiles of global remission and personal recovery
Authors: Munuera Caroline , Compagnone Philippe , Gard Sébastien , Chevrier François , Chevrier Basilie , M'Bailara Katia 
Published: December 2024

AbstractObjectivesClinical heterogeneity is a major problem in mental health, referring to wide clinical variability among people with the same diagnosis. In bipolar disorders (BD), an heterogeneity was found both in global remission (symptomatic and functional) and in personal recovery during euthymia. This heterogeneity is a challenge for clinicians, who have to adapt their care to the individuals' characteristics. This preliminary study aimed at identifying profiles of experiences during euthymia by considering global remission (manic and depressive symptomatology, and functional impairment) and personal recovery, and exploring personal and contextual correlates associated with the heterogeneity of experiences.MethodsA convenience sample of 58 participants in euthymia of BD was recruited. Data were collected using self‐report questionnaires. Consistent with a person‐oriented approach, clustering was performed to identify profiles by simultaneously considering symptomatology, functional impairment, and personal recovery. Associations between the identified profiles and socio‐demographic, clinical, and family characteristics were explored using analysis of variance, Fisher's exact tests, and post hoc tests.ResultsFive profiles were identified when considering both global remission and personal recovery: adverse experience (20.69%), slightly adverse experience (22.41%), unbalanced experience (10.34%), positive experience (22.14%), and hyperthymic positive experience (24.14%). Among the correlates, only current family functioning was significantly associated with the identified profiles through cohesion, communication, and satisfaction dimensions.ConclusionsThese results highlight that personal recovery and family dynamics of people with BD should be more considered in the clinical practice to better understand their experience during euthymia and adapt therapeutic care accordingly.
Literature and Psychoanalytic Process: A Look Through The Lens of Metaphor
Authors: Enckell Henrik 
Published: December 2024

AbstractIn this paper, the author highlights some aspects of the psychoanalytic process through the perspective of poetic metaphors. In reading new metaphors, we often become bewildered. A literal reading, and a first hand meaning, comes to nothing. A concrete reference, as well as truth, is likewise destroyed. On the ruins of these literary dimensions, however, a second hand reading, meaning, world, and truth may be formed. To take a step from literal understanding to a metaphoric one is demanding, as the former provides safety. The same is true of the position of the psychoanalytic patient. He or she needs to leave an idiosyncratic, well known, way of apprehending world and others, to take perspectives never tried before. The challenges and vulnerabilities the patient meets when facing the possibilities of starting a psychoanalytic process are compared to the position of the reader of poetic metaphors. The argument is illustrated with a psychoanalytical case.
Antidepressant Medication and Psychotherapy: Why It Matters
Authors: Chiesa Marco 
Published: December 2024

AbstractMany patients enter psychotherapy while being on antidepressant medication. This article outlines and discusses the main effects of antidepressant medication both on the patient and on the psychotherapy process. Although widely prescribed, the effectiveness of antidepressant medication is still open to debate, and several authors have questioned whether it is more effective than placebo. The multi‐faceted adverse effects of antidepressants include emotional blunting, sexual dysfunction, a number of physical ailments and chronicity in the course of depression. These adverse effects are often not easy to identify as stemming from the medication and may be mistakenly attributed to the patient's own emotional difficulties. This presents a challenge to the process of psychotherapy with the risk of creating an impasse and unfavourable outcome. In most cases, a gradual process of withdrawal from antidepressant medication is necessary to reduce the impact of these side effects both on the patient's quality of life and on the psychotherapy process. A clinical case of a patient with a 10‐year history of psychiatric medication and hospitalisations, who was suffering from medication stressful adverse effects while not improving psychiatrically. A gradual withdrawal of psychiatric medication coupled with a combination of supportive and exploratory psychotherapy led to a more favourable prognosis and clear improvements in the patient's life.
Comparing ambulatory to inpatient percutaneous nephrolithotomy: systematic review and meta‐analysis
Authors: Du Katie , Uy Michael , Cheng Alan , Millan Braden , Shayegan Bobby , Matsumoto Edward 
Published: December 2024

ObjectivesTo investigate the differences in perioperative characteristics and postoperative outcomes between inpatient and ambulatory percutaneous nephrolithotomy (PCNL) with a subgroup analysis of same‐day discharge (SDD) patients, summarise published ambulatory pathways and compare cost and satisfaction data.Patients and MethodsThis study was completed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines and registered a priori with the International Prospective Register of Systematic Reviews (PROSPERO: CRD42023438692). Ambulatory PCNL was defined as patients who were discharged after an overnight stay (≤23 h) and SDD was considered a subgroup discharged on postoperative Day 0.ResultsA total of 25 studies were included in the systematic review, of which 12 comparative studies were utilised for meta‐analysis. We had a pooled population of 2463 patients, of which 1956 (79%) ambulatory (747 [30%] SDD) and 507 (21%) inpatients. The ambulatory PCNL cohort had fewer overall complications (risk ratio [RR] 0.65, 95% confidence interval [CI] 0.47–0.90; P = 0.010); however, there were no differences in major complications (i.e., Clavien–Dindo Grade ≥III; RR 0.46; 95% CI 0.17–1.21; P = 0.12), emergency department visits (RR 1.09, 95% CI 0.69–1.74; P = 0.71), 30‐day readmission (RR 1.09, 95% CI 0.54–2.21; P = 0.81) or readmission at any point (RR 1.00, 95% CI 0.53–1.88; P = 0.99). The ambulatory PCNL cohort was more likely to be stone‐free defined by imaging (RR 1.35, 95% CI 1.09–1.66; P = 0.005); however, when stone‐free was inclusive of any definition there was no difference in stone‐free rates (RR 1.10, 95% CI 0.98–1.23; P = 0.10). Subgroup analysis of SDD did not result in any significant differences. Cost savings ranged from $932.37 to a mean (standard deviation) $5327 (442) United States Dollars per case. No studies reported patient satisfaction data.ConclusionsAmbulatory PCNL seems to be a safe and efficacious model for select patients. Selection bias likely influenced ambulatory outcomes; however, this supports overall safety of current ambulatory inclusion criteria.
The impact of positive surgical margins after cystectomy on oncological outcomes: a nationwide study
Authors: Bosveld Jikke , Nguyen Tri Q. , Boormans Joost L. , Witjes J. Alfred , van der Heijden Antoine G. , Mehra Niven , Kiemeney Lambertus A. , Aben Katja K.H. ,   ProBCI Study Group, Meijer Richard P. , Richters Anke 
Published: December 2024

ObjectiveTo evaluate whether surgical margin status, alongside existing postoperative risk indicators, improves the identification of bladder cancer patients who may benefit from adjuvant therapy following radical cystectomy (RC).MethodsIn this nationwide cohort study, patients aged ≥18 years diagnosed with muscle‐invasive bladder cancer (MIBC) without nodal or distant metastasis (cT2‐4aN0/xM0) between November 2017 and December 2020 who underwent RC were selected from the Netherlands Cancer Registry. Detailed information on surgical margin status was obtained through linkage with the Dutch central pathology database, Palga. Overall survival (OS) and progression‐free survival (PFS) were assessed using the Kaplan–Meier method. Multivariable Cox regression analysis was performed to assess the independent prognostic effect of positive surgical margins (carcinoma in situ (CIS) only or invasive carcinoma) on PFS and OS.ResultsWe identified 1445 MIBC patients treated by RC (53% open, 47% robot‐assisted), of whom 135 (9.3%) had positive surgical margins (10.7% in the open and 7.7% in the robot‐assisted cohort). In the entire cohort, OS was 79% and 60% at 12 and 48 months after RC, respectively. PFS was 70% and 61% at 12 and 24 months, respectively. Multivariable Cox regression showed worse PFS (hazard ratio (HR) 2.13, 95% confidence interval (CI) 1.67–2.72) and OS (HR 2.02, 95% CI 1.58–2.58) in patients with surgical margins with invasive carcinoma vs patients with negative margins. Patients with only CIS in the margins also appeared to have worse PFS (HR 1.60, 95% CI 1.00–2.58) but these results were not statistically significant. No difference was found for OS (HR 1.30, 95% CI 0.80–2.12).ConclusionPositive margins should be considered a ‘high risk feature’, as they result in increased risk of disease progression and impaired survival outcomes. These findings support further investigation of the potential efficacy of adjuvant therapy (i.e., radiotherapy and systemic therapy) among patients with positive surgical margins.
Sun, Sea and Sand; Cretaceous Source to Sink Systems of Senegal, NW Africa
Authors: Pearson M. , Casson M. , Pashley V. , Redfern J. 
Published: December 2024

ABSTRACTPaleo source to sink system analysis requires a complete earth systems model approach, utilising regional geology, tectonics, climate and modern‐day source to sink analogues. This study examines the Cretaceous source to sink systems of Senegal, NW Africa, integrating a broad regional dataset using a multidisciplinary mineralogical approach. The most significant regional geological and tectonic events to affect Senegal since the Pan‐African Orogenies (800–520 Ma) are the Hercynian Orogeny (320–290 Ma), Pangea break‐up and rifting between S. America and Africa, with associated Central Atlantic Magmatic Province volcanism (200 Ma) and uplift of the Mauritanide hinterland (113–66 Ma). In addition to tectonic controls, climate is the principal driver for paleo‐drainage reorganisation. During the Cretaceous an antithetical shift in climate from warm and arid (145–115 Ma), to hot and humid (100–88 Ma), increased fluvial catchment and energy. Antecedent paleo‐drainage of the Cretaceous Senegalese Basin is governed by subsurface grabens striking hundreds of kilometres into the continent formed during Atlantic rifting. Early Cretaceous aridity restricted fluvial catchments to recycling pre‐Cretaceous basinal sediments. Climate change triggered expansion of paleo‐drainage catchments during the Aptian caused fluvial incision and erosion of the Gaouâ Group Hercynian to Pan‐African age source rocks along the western flank of the Mauritanides. Exhumation increased significantly throughout the Cretaceous Thermal Maximum during the Cenomanian–Turonian, with exhumation of the Gadel Group Pan‐African source rocks, evidenced from a shift between a garnetiferous to staurolitic basin mineralogy. Inclusion of 200 Ma zircons into the central Senegalese Basin during the Albian is evidence of possible catchment shifts to include CAMP detritus from the Fouta Djallon Plateau. Cretaceous basinal sediments are almost exclusively sourced from the Mauritanide belt which includes Hercynian metamorphic host rocks and Palaeozoic sediments ultimately derived from the erosion of the Pan‐African orogenic belts. During the Maastrichtian, the central fluvial systems breached the southern Mauritanides, sourcing Cambrian zircons from the south.
Comprehensive Analysis of TEK Variants in Patients With Vascular Malformations
Authors: Ghasemi Reza , Corliss Meagan M. , Bowling Kevin M. , Krysiak Kilannin , Walker Jason , Dickson Alexa M. , Schroeder Molly C. , Parikh Bijal A. , Neidich Julie A. , Polonis Katarzyna , Cao Yang 
Published: December 2024

ABSTRACTPathogenic variants in the receptor tyrosine kinase TIE2, encoded by TEK, are known to cause vascular malformations (VMs). In this study, we retrospectively reviewed the deidentified data generated through clinical NGS testing in our laboratory and found 88 VM cases with a total of 107 clinically significant TEK variants. Among those, 23 unique variants at the amino acid level were identified, including five novel (p.Cys1040Arg, p.Arg1099PhefsTer12, p.Glu1109Ter, p.Phe1111LeufsTer7, p.Phe1111ValfsTer7) and 18 previously published variants. Missense variants were identified more often in the tyrosine kinase domain, while all nonsense/frameshift variants were clustered in the C‐terminal tail (CTT). In addition, most variants occurred as solitary alterations, whereas certain variants always co‐occurred with a second TEK variant. Five patterns of TEK variants (P1–P5) were identified: (P1) Arg849 + another variant; (P2) Tyr897 + another variant; (P3) Leu914 single variants; (P4) Arg915/918 single variants; and (P5) CTT single /co‐occurring variants. This study provides the most comprehensive view of pathogenic TEK variants in VMs to date.
Movement Ecology of a Coastal Foundation Seagrass Species: Insights From Genetic Data and Oceanographic Modelling
Authors: Ruocco Miriam , Lacorata Guglielmo , Palatella Luigi , Provera Isabella , Zenone Arturo , Martinez Marco , Dattolo Emanuela , Pazzaglia Jessica , Giacalone Vincenzo Maximiliano , Badalamenti Fabio , Procaccini Gabriele 
Published: December 2024

ABSTRACTAimSeed dispersal plays a key role in shaping the distribution and genetic complexity of seagrass populations and affects their resilience capacity under disturbance. The endemic seagrass Posidonia oceanica is a key component of Mediterranean coastal ecosystems, but knowledge about movement ecology in this species is limited, especially regarding seed movement pathways and dispersal potential.LocationWestern coast of Sicily (central Mediterranean).MethodsBeach‐cast fruits of the Mediterranean seagrass P. oceanica were collected from nine localities along the Western coast of Sicily, along with adult shoots from eight putative donor meadows. We determined pair‐wise genetic differentiation between established meadows and seed cohorts. Genetic assignment tests were used to infer the most likely meadow of origin of individual seeds and were complemented with forward and backward Lagrangian simulations of dispersal.ResultsA significant genetic differentiation was found between seed pools and the most‐likely meadow of origin. The genetic assignment confirmed that seeds from the same cohort originated from multiple meadows and emphasised the presence of long‐distance‐dispersal (LDD) events (up to hundreds of km). Genetic connectivity appeared to be greater than that predicted by oceanographic simulations, which may reflect the longer temporal scales on which gene flow is shaped, in contrast to contemporary dispersal patterns. Lagrangian simulations highlighted that fruits were physically capable of dispersing beyond the study area and that the north Tunisian coast could be a key source of propagules for the populations studied.Main ConclusionsOur study represents a significant step forward in the understanding of P. oceanica movement ecology and could guide meadows' conservation and restoration actions. Our findings are significant in a broader context outside of the research area and could be the basis of similar studies in other regions, especially considering the increasing number of fruiting events recorded across the Mediterranean likely associated with ocean warming.
New Fetal Sonographic Marker to Rule Out Total Anomalous Pulmonary Venous Return: Color Doppler Drainage From Pulmonary Vein to Atrium to Ventricle (CDDVAV)
Authors: Chainarong Natthicha , Anton Tracy , Satou Gary , Voleti Sonia , DeVore Greggory , Ambrowitz Karen , Sklansky Mark 
Published: December 2024

ABSTRACTMany cases of total anomalous pulmonary venous return (TAPVR) present with life‐threatening pulmonary venous obstruction within hours following delivery. As a result, prenatal detection represents an important approach to optimizing outcome. Unfortunately, TAPVR remains one of the most challenging major forms of congenital heart disease to detect prenatally; most cases elude diagnosis until postnatal life, despite the widespread recognition of multiple fetal two‐dimensional (2D) and color Doppler sonographic markers. This commentary demonstrates that even the 2D and color Doppler appearance of pulmonary venous drainage to the left atrium may be seen in cases of TAPVR. Accordingly, we describe, for the first time, a novel color Doppler fetal sonographic marker to rule out TAPVR.