bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central nervous system involvement in arthrogryposis multiplex congenita: Overview of causes, diagnosis, and care
Authors: Dieterich Klaus , Kimber Eva , Hall Judith G. 
Published: August 2019

AbstractArthrogryposis or AMC, arthrogryposis multiplex congenita, is defined as multiple congenital joint contractures in more than two joints and in different body areas. The common cause of all AMC is lack of movement in utero, which in turn can have different causes, one of which is CNS involvement. Intellectual disability/CNS involvement is found in approximately 25% of all AMC. AMC with CNS involvement includes a large number of genetic syndromes. So far, more than 400 genes have been identified as linked to AMC, with and without CNS involvement. A number of neonatally lethal syndromes and syndromes resulting in severe disability due to CNS malfunction belong to this group of syndromes. There are several X‐linked disorders with AMC, which are primarily related to intellectual disability. A number of neuromuscular disorders may include AMC and CNS/brain involvement. Careful clinical evaluation by a geneticist and a pediatrician/pediatric neurologist is the first step in making a specific diagnosis. Further investigations may include MRI of the brain and spinal cord, electroencephalogram, blood chemistry for muscle enzymes, other organ investigations (ophtalmology, cardiology, gastrointestinal, and genitourinary systems). Nerve conduction studies, electromyogram, and muscle pathology may be of help when there is associated peripheral nervous system involvement. But most importantly, genetic investigations with targeted or rather whole exome or genome sequencing should be performed. A correct diagnosis is important in planning adequate treatment, in genetic counselling and also for future understanding of pathogenic mechanisms and possible new treatments. A multidiciplinary team is needed both in investigation and treatment.
Multilayer‐Functionalized Reduced Graphene Oxide Decorated with Gold Nanoparticles as a Designed Nanonanocatalyst for the Selective Oxidation of Cyclohexene by Molecular Oxygen in a Solvent‐Free System
Authors: Shahabi Nejad Mohaddeseh , Behzadi Soheila , Sheibani Hassan 
Published: August 2019

The aerobic oxidation of cyclohexene is of great significance from the viewpoints of both fundamental and industry studies as it can transfer the petrochemical feedstock into valuable chemicals. In this research, gold nanoparticles were synthesized on the multi‐layer functionalized reduced graphene oxide. The surface of reduced graphene oxide (rGO) was modified with hydrophobic and hydrophilic layers to create the rGO with scattered hydrophilic positions. The gold nanoparticles were synthesized and immobilized simultaneously in small hydrophilic micro reactors in a mild condition. Characterization of synthesized nanocatalyst was confirmed with different techniques such as TEM, XRD, FT‐IR, and SEM. TEM images of synthesized catalyst show the gold nanoparticles have diameters less than 5 nm. Designed nanonanocatalyst was investigated for the selective liquid phase oxidation of cyclohexene with molecular oxygen in solvent free condition which after optimized conditions a maximum of 88% conversion and 91% selectivity was obtained.
Insights into Polymerization of Vegetable Oil: Oligomerization of Oleic Acid
Authors: Bonetti Rino , Parker Wallace O. 
Published: August 2019

AbstractViscous gel‐like species form in vegetable oils during frying. After fatty acid formation, thermal oxidation of unsaturated chains causes polymerization. Heat treatment of oleic acid was employed to produce and identify the initial polymerization products. Spectroscopic studies revealed that heating oleic acid (210 °C, open to air) causes the formation of oligomers cross‐linked by ester groups. The absence of esters, before thermal treatment, facilitated observation of cross‐links (ester groups) that propagate to produce heavier insoluble products.
Rhodamine B hydrazide loaded polysulfone fabrics for Cu(II) detection: Morphological and optical properties
Authors: Morsi Rania E. , Elsawy Moataz , Ali MennatAllah M. , Gentili Denis , Cavallini Massimiliano , Manet Ilse , Bandini Elisa , Venturini Alessandro , Benaglia Massimo , Ventura Barbara 
Published: August 2019

ABSTRACTPolysulfone‐based materials were fabricated as casted films, porous membranes, and nanofibers by solution casting, phase inversion process, and electrospinning technique, respectively. Photoactive rhodamine B hydrazide molecules were loaded into the fabrics either in preloading or postloading processes. The morphological structure of the fabrics was investigated by scanning electron microscopy and the wettability was determined by contact angle measurements. Detailed spectroscopic characterizations of the closed and open forms of rhodamine B was performed both in solution and in the solid‐state composite materials. Theoretical investigations supported the depiction of the absorption and emission features of the two forms. The response of the prepared composite materials to Cu(II) ions has been tested by absorption and emission spectroscopy and confocal fluorescence imaging. The most effective materials for Cu(II) detection were found to be polysulfone films prepared by phase inversion and postloaded with 10% rhodamine B hydrazide. These results open the way to the development of composite sensory membranes. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48408.
Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes
Authors: Liang Hai‐wei , Luo Bin , Du Li‐hua , He Rong‐quan , Chen Gang , Peng Zhi‐gang , Ma Jie 
Published: August 2019

AbstractObjectiveTo investigate the expression level and potential mechanism of hypoxia‐inducible factor 1 alpha (HIF‐1α) in patients with myelodysplastic syndromes (MDS).MethodsImmunohistochemistry (IHC) techniques were used to examine the protein expression of HIF‐1α in paraffin‐embedded myeloid tissues from 82 patients with MDS and 33 controls (patients with lymphoma that is not invading myeloid tissues). In addition, the associations between the protein expression of HIF‐1α and clinical parameters were examined. To further investigate the significance of HIF‐1α expression in MDS patients, the researchers not only extracted the data about HIF‐1α expression from MDS‐related microarrays but also analyzed the correlation between the level of HIF‐1α expression and MDS. The microRNA (miRNA) targeting HIF‐1α was predicted and verified with a dual luciferase experiment.ResultsImmunohistochemistry revealed that the positive expression rate of HIF‐1α in the bone marrow of patients with MDS was 90.24%. This rate was remarkably higher than that of the controls (72.73%) and was statistically significant (P < .05), which indicated that HIF‐1α was upregulated in the myeloid tissues of MDS patients. For the GSE2779, GSE18366, GSE41130, and GSE61853 microarrays, the average expression of HIF‐1α in MDS patients was higher than in the controls. Particularly for the GSE18366 microarray, HIF‐1α expression was considerably higher in MDS patients than in the controls (P < .05). It was predicted that miR‐93‐5p had a site for binding with HIF‐1α, and a dual luciferase experiment confirmed that miR‐93‐5p could bind with HIF‐1α.ConclusionThe upregulated expression of HIF‐1α was examined in the myeloid tissues of MDS patients. The presence of HIF‐1α (+) suggested an unsatisfactory prognosis for patients, which could assist in the diagnosis of MDS. In addition, miR‐93‐5p could bind to HIF‐1α by targeting, showing its potential to be the target of HIF‐1α in MDS.
Alcohol septal ablation in patients with concomitant hypertrophic cardiomyopathy and aortic valvular stenosis
Authors: El‐Sabawi Bassim , Nishimura Rick A. , Guerrero Mayra E. , Rihal Charanjit S. , Eleid Mackram F. 
Published: August 2019

AbstractObjectiveTo describe the hemodynamic and early clinical outcomes of percutaneous alcohol septal ablation in patients with concomitant dynamic left ventricular outflow tract (LVOT) obstruction and aortic valvular stenosis (AS).BackgroundAlcohol septal ablation is an established method to relieve dynamic LVOT obstruction in patients with hypertrophic cardiomyopathy (HCM). However, the feasibility, safety, and efficacy of alcohol septal ablation in patients with serial obstructions from HCM and AS remain unclear.MethodsIn this case series, we describe the early outcomes of alcohol septal ablation in six patients with significant dynamic LVOT obstruction and AS. All patients had evidence of severe dynamic LVOT obstruction (resting or provoked gradient ≥50 mmHg), mild to severe AS, and NYHA class III symptoms or greater.ResultsFour (66.7%) patients had septal ablation performed in the setting of concomitant native valvular AS and two (33.3%) patients had TAVR performed prior to septal ablation. Successful alcohol septal ablation was performed in all patients and was associated with an immediate reduction of the dynamic LVOT gradient with a residual fixed obstruction related to AS. Four (66.7%) patients had follow‐up at 1 month and of these, three (75%) had NYHA Class I–II symptoms and one (25%) Class III.ConclusionsAlcohol septal ablation is a feasible method of relieving dynamic LVOT obstruction in patients with concomitant HCM and AS. Further study is required to determine the optimal treatment approach in these patients.
Improved Electrochemical Performance of FeF3 by Inlaying in a Nitrogen‐Doped Carbon Matrix
Authors: Li Jia , Fu Licai , Zhu Jiajun , Yang Wulin , Li Deyi , Zhou Lingping 
Published: August 2019

AbstractFeF3 is favored by researchers because of its high theoretical specific capacity and high voltage. It is expected to be utilized as a cathode material for lithium‐ion batteries in the future. However, the poor electronic conductivity, inferior reaction kinetics, and severe volume expansion seriously prevents its practical application. Herein, a FeF3@N‐doped carbon nanocomposite was successfully produced by in situ fluorination and dehydration. In addition, the nanocomposite showed a reversible capacity of 84.9 mAh g−1 for 200th cycle after cycling at a high current of 2 C, which is approximately 300 times higher than that of bare FeF3. Benefitting from the N‐doped carbon matrix, the composite electrodes exhibited minor transfer resistance (117.4 Ω, only 44.0 % of that of bare FeF3) and very low polarization voltage (ca. 0.19 V). Meanwhile, it provided a buffer for volume expansion during the insertion of Li+ and maintained cycling stability. This work can supply a simple pathway for designing ultrahigh‐rate and long‐life FeF3 cathode materials.
Adsorption for perfluorooctanoic acid with graphitic‐phase carbon nitride and its HPLC fluorescence determination
Authors: Hu Xiao , Liu Yan , Yang Rongguang , Jiang Yinhua , Meng Minjia , Liu Zhanchao , Ni Liang , Wu Weifu , Liu Hongwei 
Published: August 2019

AbstractIn this paper, graphitic‐phase carbon nitride (g‐C3N4) was prepared from urea and detected by FTIR, XRD, SEM, TEM, Boehm titration, zeta potential, and N2 adsorption‐desorption analyzes, demonstrating that g‐C3N4 possesses a thin sheet structure, negative surface, and strong alkalinity. Considering the alkaline groups and huge areas, g‐C3N4 was employed to adsorb perfluorooctanoic acid (PFOA). The adsorption capacity of g‐C3N4 towards PFOA was evaluated by batch adsorption experiments, indicating the considerable adsorption capacity of 120.879 mg g−1. The isothermal models and kinetic models were also performed in order to study the adsorption process, proving that PFOA adsorption was fitted by the Langmuir isothermal model and pseudo second‐order model. In addition, residual PFOA concentration after adsorption was determined by high performance liquid chromatography (HPLC) with a fluorescence detector after being derived with 3‐(2‐bromoacetyl) coumarin (3‐BrAC). The HPLC fluorescent detection showed satisfied linearity from 0.5 to 20.0 ug mL−1 with a sound R
2 of 0.9992. This is the first time that g‐C3N4 was applied to PFOA adsorption from aqueous solutions with outstanding adsorption capacity.
Transition‐Metal‐Free Defluorosilylation of Fluoroalkenes with Silylboronates
Authors: Gao Pan , Wang Guoqiang , Xi Longlong , Wang Minyan , Li Shuhua , Shi Zhuangzhi 
Published: August 2019

Summary of main observation and conclusionSilylated fluoroalkenes are important synthetic intermediates with complementary reactivity, which play a key role in the construction of natural products, pharmaceuticals, and manmade materials. Converting the normally highly stable fluoroalkenes into silylated fluoroalkenes by selective defluorosilylation is a challenging task. Herein, we report a simple, inexpensive and robust defluorosilylation of a variety of fluoroalkenes with silylboronates in the presence of alkoxy base to directly synthesize various silylated fluoroalkenes. The protocol features mild and safe reaction conditions that avoid a catalyst, a transition metal, a ligand, and high reaction temperature and tolerates a wide scope of fluoroalkene substrates without compromising the efficiency. Density functional theory calculations show that transient silyl anion complex undergoes an SN2’ or SNV substitution, which is responsible for this base‐mediated defluorosilylation.
Mapping of ventricular tachycardia in patients with ischemic cardiomyopathy: Current approaches and future perspectives
Authors: Pandozi Claudio , Lavalle Carlo , Russo Maurizio , Galeazzi Marco , Ficili Sabina , Malacrida Maurizio , Centurion Aznaran Carlos , Colivicchi Furio 
Published: August 2019

AbstractDespite the technical improvements made in recent years, the overall long‐term success rate of ventricular tachycardia (VT) ablation in patients with ischemic cardiomyopathy remains disappointing. This unsatisfactory situation has persisted even though several approaches to VT substrate ablation allow mapping and ablation of noninducible/nontolerated arrhythmias. The current substrate mapping methods present some shortcomings regarding the accurate definition of the true scar, the modality of detection in sinus rhythm of abnormal electrograms that identify sites of critical channels during VT and the possibility to determine the boundaries of functional re‐entrant circuits during sinus or paced rhythms. In this review, we focus on current and proposed ablation strategies for VT to provide an overview of the potential/real application (and results) of several ablation approaches and future perspectives.
Late mortality after bone marrow transplant for chronic myelogenous leukemia in the context of prior tyrosine kinase inhibitor exposure: A Blood or Marrow Transplant Survivor Study (BMTSS) report
Authors: Wu Jessica , Chen Yanjun , Hageman Lindsey , Francisco Liton , Ness Emily C. , Parman Mariel , Kung Michelle , Watson James A. , Weisdorf Daniel J. , Snyder David S. , McGlave Philip B. , Forman Stephen J. , Arora Mukta , Armenian Saro H. , Bhatia Ravi , Bhatia Smita 
Published: August 2019

BackgroundLate mortality was investigated in patients with chronic myelogenous leukemia (CML) who underwent blood or bone marrow transplant (BMT) with or without prior tyrosine kinase inhibitor (TKI) therapy.MethodsBy using data from the Blood or Marrow Transplant Survivor Study, the authors examined late mortality in 447 patients with CML who underwent BMT between 1974 and 2010, conditional on surviving ≥2 years post‐BMT. For vital status information, the medical records, the National Death Index, and the Accurint database were used. Standardized mortality ratios (SMRs) were calculated using general population age‐specific, sex‐specific, and calendar‐specific mortality rates. Kaplan‐Meier techniques and Cox regression were used for all‐cause mortality analyses. Cumulative incidence and proportional subdistribution hazards models for competing risks were used for cause‐specific mortality analyses.ResultsThe 10‐year overall survival rate was 65.7% and 73% for those who underwent transplant with and without pre‐BMT exposure to TKI therapy, respectively. Patients who underwent transplant with and without pre‐BMT TKI experienced SMRs of 6.4 and 6.4, respectively (P = .8); and the SMRs were 11.6 and 8.1, respectively, for those with high‐risk disease (P = .2). Independent predictors of non–CML‐related mortality included chronic graft‐versus‐host disease (hazard ratio [HR], 2.8; 95% CI, 1.8‐4.4) and busulfan/cyclophosphamide conditioning (HR, 0.5; 95% CI, 0.3‐0.9; reference, total body irradiation/cyclophosphamide conditioning). The 20‐year cumulative incidence of CML‐related and non–CML‐related mortality was 6% and 36%, respectively, for the entire cohort. Both CML‐related mortality (HR, 1.0; 95% CI, 0.1‐12.6) and non–CML‐related mortality (HR, 1.3; 95% CI, 0.6‐3.1) were comparable for those with and without pre‐BMT TKI therapy.ConclusionsThe similar late mortality experienced by patients with CML who undergo transplantation with or without pre‐BMT TKIs suggests that allogeneic BMT can be considered in the context of TKI intolerance or nonadherence. The prevention of post‐BMT non–CML‐related mortality could favorably affect long‐term survival.
Deep neural network model construction with interactive code reuse and automatic code transformation
Authors: Lee Keon Myung , Park Ki‐Sun , Hwang Kyung‐Soon , Kim Kwang‐Il 
Published: August 2019

SummaryMany application developers have been recently interested in applying deep learning techniques to their works but have little knowledge and experience on them. This paper presents the methods for a GUI‐based modeling tool to easily build deep learning models and automatically transform them into executable program codes. For reuse of existing deep learning codes, it introduces a method that imports such a program code, extracts the deep learning model architecture, and transforms it into a graphical representation that can be modified on a graphical interface. Meanwhile, a deep learning model with many layers is difficult to be visualized on a small display screen. To handle the difficulty, it proposes a method to identify the submodules called articulable subgraphs in a deep learning model and to organize the deep learning model into a hierarchical architecture using the nesting relationships of articulable subgraphs. It introduces a method to identify frequent substractures as well as articulable subgraphs as building blocks for deep learning models for levelwise views. The hierarchical representation easily enables to build deep learning models with many layers. The GUI‐based modeling tool employing the proposed methods makes nonexpert developers easily use deep learning techniques in their practical applications.
Socially responsible investment returns and news: Evidence from Asia
Authors: Yen Meng‐Feng , Shiu Yung‐Ming , Wang Chi‐Feng 
Published: August 2019

AbstractWe set out in this study to examine (a) whether “socially responsible investment” (SRI) portfolios can outperform less‐SRI portfolios in the emerging Asian stock markets and (b) whether investors within these emerging markets achieve awareness of SRI through publicly available news. On the basis of 2009–2013 data, we find that SRI portfolios tend to perform better in Japan. However, firms in the emerging Asian markets do not earn rewards for superior corporate social responsibility (CSR) practices. We also find that investors in the emerging Asian markets are indeed aware of SRI through public CSR news releases; in particular, investors in these markets reward high environmental‐, social‐, and governance‐rated firms for their good CSR practices advertised through such news releases, relative to those with no news releases.
Modified method for transformer magnetizing characteristic computation and point‐on‐wave control switching for inrush current mitigation
Authors: Yahiou Abdelghani , Bayadi Abdelhafid , Babes Badreddine 
Published: August 2019

SummaryThis paper proposes a new model for the low‐frequency transient analysis of a transformer, with a modified equation for calculation of the flux‐current characteristic representing the saturation inductance of the transformer. The model is based on the V‐I (voltage‐current) no‐load curves and uses the no‐load reactive power losses. To validate the model, it was used to simulate the no‐load magnetizing current in steady‐state condition, as well as the transient inrush current at network frequency. Evaluation was done both by comparing the simulation results obtained with the proposed model and those available in the relevant literature, and by practical measurements. The experimental results presented in this paper were obtained via a laboratory setup and a data acquisition system based on the dSPACE board 1104. Moreover, a control switching to mitigate the transient inrush current in a transformer was developed and applied experimentally in the laboratory and also in the simulations. This control strategy was performed by taking into account the residual flux at the opening instant of the related circuit breaker. A comparative study was carried out showing the validity of the proposed model and the mitigation technique.
A fast tag identification anti‐collision algorithm for RFID systems
Authors: Wijayasekara Sanika Krishnamali , Nakpeerayuth Suvit , Annur Robithoh , Hsieh Hung‐Yun , Sanguankotchakorn Teerapat , Sandrasegaran Kumbesan , Srichavengsup Warakorn , Phromsa‐ard Tharathorn , Wuttisittikulkij Lunchakorn 
Published: August 2019

SummaryIn this work, we propose a highly efficient binary tree‐based anti‐collision algorithm for radio frequency identification (RFID) tag identification. The proposed binary splitting modified dynamic tree (BS‐MDT) algorithm employs a binary splitting tree to achieve accurate tag estimation and a modified dynamic tree algorithm for rapid tag identification. We mathematically evaluate the performance of the BS‐MDT algorithm in terms of the system efficiency and the time system efficiency based on the ISO/IEC 18000‐6 Type B standard. The derived mathematical model is validated using computer simulations. Numerical results show that the proposed BS‐MDT algorithm can provide the system efficiency of 46% and time system efficiency of 74%, outperforming all other well‐performed algorithms.
Untersuchung und Sanierung eines feuchten Kellermauerwerks (Gutachten)
Authors: Pittino Philipp , Hafellner Hans 
Published: August 2019

AbstractIn the following expertise report, the existing condition of the cellar of a semi‐detached house, which was built in a coupled construction, is analysed and considerations for a hygric refurbishment are discussed. First and foremost, it was necessary to find the cause of the damp present in the outside walls of the cellar of the building. In order to describe the current characteristics of the building, an inventory analysis was made of obvious building defects. This is summarised and described in the following report, which was the basis for all further proceeding. Building physics measurements and evaluations were carried out, building materials were examined for their physical properties and corresponding evaluations and analyses were carried out. Finally, all measurement results and findings were collected to provide a conclusive explanation for the existing defects to the building fabric of the building. This in turn was the foundation for all further measures to be taken in order to determine the necessary remediation concepts and changes to the interior design or the use of the rooms. The aim was to make the cellar space fully usable again and to be able to hand over a list of proposals for the necessary technical remediation measures to the client.