bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-Related Quality of Life Impact from Adding Bevacizumab to Cisplatin-Pemetrexed in Malignant Pleural Mesothelioma in the MAPS IFCT-GFPC-0701 Phase III Trial
Authors: Eberst Guillaume , Anota Amélie , Scherpereel Arnaud , Mazieres Julien , Margery Jacques , Greillier Laurent , Audigier-Valette Clarisse , Moro-Sibilot Denis , Molinier Olivier , Léna Hervé , Rivière Frédéric , Monnet Isabelle , Gounant Valérie , Janicot Henri , Gervais Radj , Locher Chrystelle , Charton Emilie , Morin Franck , Zalcman Gérard , Westeel Virginie 
Published: June 2019

Abstract

Purpose:
The IFCT-GFPC-0701 MAPS phase III trial highlighted significant improvement in overall survival from adding bevacizumab to the standard first-line chemotherapy regimen [cisplatin plus pemetrexed (PC)] in advanced malignant pleural mesothelioma (MPM). We present the results of health-related quality of life (HRQoL), a secondary endpoint of MAPS.

Patients and Methods:
HRQoL was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire QLQ-C30 and the lung cancer–specific module QLQ-LC13 at randomization and then every 9 weeks until disease progression.
HRQoL deterioration–free survival (QFS), used to analyze longitudinal HRQoL data, was defined as the interval between randomization and the occurrence of the first clinically relevant definitive deterioration compared with the HRQoL score at baseline, or death.

Results:
A total of 448 patients were included in the MAPS trial between 2008 and 2014. At baseline, 425 patients (94.8%) completed the HRQoL questionnaire. We report that adding bevacizumab to cisplatin and pemetrexed (PCB) significantly improved QFS for the peripheral neuropathy dimension, with a median QFS of 12.09 months [95% confidence interval (CI), 9.59–13.67] in the PCB arm versus 7.59 months (95% CI, 6.57–8.61) in the PC arm [HR (PCB vs. PC) = 0.74; 95% CI, 0.61–0.91; P = 0.004]. QFS was also longer in the PCB arm for the pain dimension (HR = 0.84; 95% CI, 0.69–1.02; P = 0.08).

Conclusions:
This study demonstrated that adding bevacizumab to standard chemotherapy in patients with advanced MPM had no negative impact on HRQoL. A significant improvement in the peripheral neuropathy and pain HRQoL dimensions was even observed.
Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data
Authors: Ventz Steffen , Lai Albert , Cloughesy Timothy F. , Wen Patrick Y. , Trippa Lorenzo , Alexander Brian M. 
Published: June 2019

Abstract

Purpose:
We discuss designs and interpretable metrics of bias and statistical efficiency of “externally controlled” trials (ECT) and compare ECT performance to randomized and single-arm designs.

Experimental Design:
We specify an ECT design that leverages information from real-world data (RWD) and prior clinical trials to reduce bias associated with interstudy variations of the enrolled populations. We then used a collection of clinical studies in glioblastoma (GBM) and RWD from patients treated with the current standard of care to evaluate ECTs. Validation is based on a “leave one out” scheme, with iterative selection of a single-arm from one of the studies, for which we estimate treatment effects using the remaining studies as external control. This produces interpretable and robust estimates on ECT bias and type I errors.

Results:
We developed a model-free approach to evaluate ECTs based on collections of clinical trials and RWD. For GBM, we verified that inflated false positive error rates of standard single-arm trials can be considerably reduced (up to 30%) by using external control data.

Conclusions:
The use of ECT designs in GBM, with adjustments for the clinical profiles of the enrolled patients, should be preferred to single-arm studies with fixed efficacy thresholds extracted from published results on the current standard of care.
Archetypes of Knowledge
Authors: Zwart H.A.E. (Hub) 
Published: June 2019

Abstract
This paper substantiates why Jung’s psychology is still highly relevant for understanding science today. I explore how his methods and insights allow us to come to terms with the phenomenon of scientific discovery. After outlining core Jungian concepts and insights concerning science, I will focus on the relationship between alchemy and modern science. Also, I will highlight Jung’s understanding of scientific research as a practice of the self, directed at individuation (the integration of various aspects of the self into a coherent whole). Finally, I discuss the role of archetypes in the context of discovery of modern science. Whereas archetypal ideas may function as sources of insight and inspiration, the task for researchers is to come to terms with them, instead of being overwhelmed by them. Besides case studies discussed by Jung himself, I also present more recent examples, taken from molecular life sciences research and climate change research.
Blockchain-Based Money as the Ultimate Challenge to Sovereignty
Authors: de Caria Riccardo 
Published: June 2019

The article considers the radical challenge that blockchain, and in particular the blockchain-based cryptocurrency Bitcoin, poses to state sovereignty. If blockchain ever succeeds to be adopted on a large scale, Bitcoin, or any other permissionless blockchain-based cryptocurrency for that matter, is a direct threat to one of the key tenets of sovereignty: the monopoly over money. Without this traditional monopoly, states will not be able to exist as they have so far. Building on this premise, the article argues that blockchain-based money is currently posing a serious challenge to state sovereignty and could therefore reshape public law.
This article also contends that Bitcoin in particular might collapse for technical reasons. However, if Bitcoin proves to be resilient enough to resist ongoing legal challenges, then the very “basic norm” of our legal systems will arguably change.
Challenges and Opportunities Brought to the Chinese Economy by Brexit and the New US Administration
Authors: Morales Lucía , Andreosso-O’Callaghan Bernadette 
Published: June 2019

The impact of Brexit and the election of Donald Trump as the 45th US president in the context of stock market reactions and economic policy uncertainty (EPU) within three key zones in ‘the Greater China Region’ (Hong Kong, Taiwan and China Mainland) are examined in this article. The chosen research period is from January 2014 to June 2017, and the EPU Index in the USA and the UK is used as a proxy to measure political uncertainty in two of the world major economies and how they impact on the Chinese stock market. The main contribution of the article can be found in the analysis of how stock market performance can be driven by policy-related uncertainty shocks in the international context. The results show that the stock markets in the ‘Greater China Region’ did not seem to react either to the uncertainty generated by Brexit or to the election of Donald Trump, implying that the Chinese stock markets appear to be quite resilient to the recent political events that have been disrupting the global economy. JEL codes: G58, G15, G18
Strength and Function Across Maturational Levels in Young Athletes at the Time of Return to Sport After ACL Reconstruction
Authors: Ithurburn Matthew P. , Paljieg Adam , Thomas Staci , Hewett Timothy E. , Paterno Mark V. , Schmitt Laura C. 
Published: June 2019

Background: The impact of maturation on lower extremity strength and function after anterior cruciate ligament reconstruction (ACLR) may help guide future studies of age-specific rehabilitation. Hypothesis Pediatric ACLR patients would demonstrate higher thigh strength symmetry and knee-related function at return to sport (RTS) compared with adolescent and young adult participants who underwent traditional ACLR. Study Design: Prospective cohort study. Level of Evidence: Level 2. Methods: A total of 144 young athletes at the time of RTS clearance post-ACLR were classified into 3 maturational groups (pediatric, n = 16 with physeal-sparing ACLR [mean age = 12.3 years; range = 9.2-14.6 years]; adolescent, n = 113 [mean age = 16.5 years; range = 14.1-19.8 years]; young adult, n = 15 [mean age = 22.0 years; range = 20.5-24.9 years]). Quadriceps and hamstring strength were measured using an electromechanical dynamometer. Knee-related function was measured using the International Knee Documentation Committee (IKDC) subjective form and single-leg hop tests. The Limb symmetry Index (LSI) was used in calculations for hop and strength tests. Group differences were compared with Kruskal-Wallis tests and Mann-Whitney U post hoc tests. Proportions of participants meeting literature-recommended RTS criterion cutoffs were compared among the groups using chi-square tests. Results: The pediatric group demonstrated higher quadriceps LSI ( P = 0.01), IKDC scores ( P < 0.01), single-hop LSI ( P < 0.01), and crossover-hop LSI ( P = 0.02) compared with the young adult group. In addition, the pediatric group demonstrated higher IKDC scores ( P < 0.01) and single-hop LSI ( P = 0.02) compared with the adolescent group. The adolescent group demonstrated higher IKDC scores ( P < 0.01), single-hop LSI ( P = 0.02), and crossover-hop LSI ( P = 0.03) compared with the young adult group. The proportions of participants meeting all RTS criterion cutoffs were highest in the pediatric group and lowest in the young adult group ( P = 0.03). Conclusion: Young athletes at RTS clearance after pediatric ACLR demonstrated higher quadriceps strength symmetry and knee-related function than adolescents and young adults after traditional ACLR. Clinical Relevance: These findings demonstrate the need for further study regarding the impact of these group differences on longitudinal outcomes after ACLR, including successful RTS and risk of second ACL injury.
Total Quality Management, Concurrent Engineering and Manufacturing Performance: An Empirical Investigation
Authors: Deshpande Anant 
Published: June 2019

The purpose of the research is to empirically investigate the relationships among the dimensions of total quality management, concurrent engineering, and manufacturing performance for a sample of 204 Indian manufacturing managers. Using the resource-based view, a theoretical framework is proposed. Structural equation modelling was used to test the relationships between the dependent and the independent variables. Our research empirically indicates, that the dimensions of total quality management and concurrent engineering have a positive impact on each other and on the manufacturing performance the firm. However, customer focus was not found to have a significant impact on cost performance. The results of the study may not be generalizable as the study was conducted only in India. As future research, the relationships may be explored in other countries and cross-country differences may be investigated. To the best of our knowledge, no study has previously investigated the linkages between the dimensions of total quality management, concurrent engineering, and manufacturing performance in a unified context. Such investigations are crucial as the results of the research may provide a concrete support for the simultaneous implementation of total quality management and concurrent engineering and motivate more organizations to engage in such practices. Understanding the interlinkages between dimensions of these practices and the performance outcomes will also provide a theoretical as well as a practical platform for organizations to gain sustainable competitive advantage.
Quantification of Cardiorespiratory Fitness in Children with Obesity
Authors: BHAMMAR DHARINI M. , ADAMS-HUET BEVERLEY , BABB TONY G. 
Published: June 2019

ABSTRACT

Purpose
Without consideration for the effects of fat mass, there could be an underestimation of cardiorespiratory fitness in children with obesity leading to a clinical diagnosis of deconditioning and resulting in unrealistic training goals and limitation of physical activities. The purpose of this study was to identify methods of quantifying cardiorespiratory fitness that were less influenced by fat mass.

Methods
Fifty-three children, 27 with obesity (10.9 ± 1.0 yr) and 26 without obesity (11.0 ± 1.0 yr), volunteered for this study. Maximal oxygen uptake, an indicator of cardiorespiratory fitness, was referenced to lean body mass, body mass, and predicted body mass at the 50th and 85th body mass index percentiles.

Results
Children with obesity carried 18 kg more fat mass and 7 kg more lean body mass compared with children without obesity. Cardiorespiratory fitness based on lean body mass, body mass, and predicted body mass at the 85th percentile was lower in children with obesity compared with children without obesity (P < 0.001). Differences in cardiorespiratory fitness based on predicted body mass at the 50th percentile between children with and without obesity did not reach statistical significance (P = 0.84). Fat mass influenced cardiorespiratory fitness least when referenced to lean body mass or predicted body mass at the 50th percentile (R
2 < 0.26) in contrast to when it was referenced to body mass or predicted body mass at the 85th percentile (R
2 > 0.37).

Conclusion
Quantifying cardiorespiratory fitness based on lean body mass or predicted body mass at the 50th percentile could be useful for estimating fitness levels in children with obesity.
‘Welcome to the World’: parents' experiences of an antenatal nurturing programme
Authors: Wadephul Franziska , Jones Catriona , Jomeen Julie 
Published: June 2019

Background The transition to parenthood lays the foundations for the parent-infant relationship, but can also be a time of increased vulnerability. It can therefore be a suitable time for interventions to increase parents' emotional wellbeing and support couple relationships as well as the relationship with the baby. Aims This study aimed to explore the experiences of attendees at an antenatal nurturing programme and its effect on their experiences of the early postnatal period. Methods A total of 36 attendees took part in six focus groups across the UK. Findings Participants' experiences of the programme were very positive; it provided knowledge and skills and gave participants a safe space in which to explore feelings and concerns. The programme encouraged participants to nurture themselves, as well as their babies and their relationships. Some groups formed strong support networks, while others did not. Conclusion Participants felt they had benefitted from the programme, particularly in terms of their emotional wellbeing and couple relationships.
Women's experiences of outpatient induction of labour
Authors: Kandola Dalvir 
Published: June 2019

BackgroundOutpatient induction of labour is offered to relieve the pressure on inpatient stay and to improve women's experiences.AimTo contribute to the knowledge of outpatient induction of labour with the focus on women's experiences to inform practice. The question was: ‘What are women's experiences of outpatient induction of labour?’MethodA comprehensive literature review using a pluralistic approach and thematic analysis.FindingsThe review found three themes: the home as a positive setting for outpatient induction of labour, the value of outpatient induction of labour in promoting normality and the importance of receiving reassurance during outpatient induction of labour.ConclusionAlthough the results were mostly positive and in favour of outpatient induction of labour, there were variations in service provision. There was a lack of understanding as to how best to offer reassurance to women once discharged home, which was found to have a direct effect on their experiences.
Educación y género en el espacio social cordobés. Una aproximación a la estructura de la desigualdad social
Authors: Jimenez Cecilia ines 
Published: June 2019

El papel que el género juega en la construcción de las clases sociales viene siendo cada vez más atendido en el campo de estudios sobre desigualdad social. Los trabajos clásicos sobre la estratificación han tendido a olvidar esta variable, o bien a subsumirla en la posición del principal sostén de hogar, que suele corresponder con un varón.
El avance durante el siglo XX de las mujeres en el acceso a derechos se ha plasmado en su creciente y constante incorporación al mercado de trabajo y al sistema educativo, sobrepasando en algunos casos las titulaciones o niveles educativos de los varones. Considerando el lugar creciente del capital cultural en la definición de las posiciones de clase, y atendiendo al aumento de inversiones de las mujeres en esta materia, proponemos una lectura de la distribución del capital cultural en las diferentes clases sociales de Gran Córdoba (2011) por género. Además, realizamos una interpretación en términos de homogamia educativa entre cónyuges. Por último, esbozamos algunas hipótesis sobre el rol de las credenciales educativas para definir la posición de las mujeres al interior de los hogares, como referentes de hogar -ya sea en situaciones conyugales o monoparentales- o como cónyuges en las diferentes clases sociales.
Humiliation Inventory: Adaptation study for Portuguese population
Authors: Cardoso Francisco M. S. , Ramos Ana C. M. , Hartling Linda M. 
Published: June 2019

Temos como principal objetivo apresentar um estudo de adaptação de um inventário de humilhação para a população Portuguesa. Tivemos como ponto de partida a versão original do inventário de Hartling e Luchetta (1999) composto por trinta e dois itens distribuídos por dois fatores: humilhação cumulativa e medo da humilhação. Participaram 1116 respondentes da população geral, Midade= 32.25, DPidade=11.5. Procedemos a uma AFC que não confirmou a estrutura fatorial inicial. Por consequência, procurámos modelos alternativos. Em primeiro lugar, realizámos uma ACP da qual resultou a extração de três fatores, denominados por humilhação cumulativa, medo/receio de humilhação e preocupação para com a humilhação que explicam cerca de 72% da variância total e apresentam boa fiabilidade. Subsequentemente, realizámos uma AFC que, após reespecificação, confirmou o modelo de três fatores com muito bom ajustamento: Satorra-Bentler(factor correction)=1.416, χ2(196)=570.766, χ2/df=2.91, CFI=.984, TLI=.981, RMSEA=.041, CI [.038, .045], SRMR=.028. De modo semelhante, apresentou bons valores respeitantes à fiabilidade compósita e fatorial e boas validades convergente e discriminante. Em conclusão, o estudo de adaptação conferiu um bom instrumento de medida, realçando um novo fator - preocupação para com a humilhação - o qual, na versão original, estava agregado ao segundo fator, medo/receio de humilhação. Esta diferença encontrada dever-se-á à diferente composição da amostra e a diferenças culturais específicas.
Solidão e sintomatologia depressiva na velhice
Authors: Faísca Letícia Raquel , Afonso Rosa Marina , Pereira Henrique , Vaz Patto Maria Assunção 
Published: June 2019

A solidão e a depressão encontram-se relacionadas com o bem-estar psicológico na velhice. Contudo, esta relação não é clara dada a complexidade destas dimensões, nomeadamente da solidão. Este estudo pretende avaliar estas duas dimensões e discutir a sua relação em pessoas idosas, considerando aspetos sociodemográficos. Participaram no estudo 213 pessoas com idades entre os 65 e os 96 anos, sendo a média de idades de 75 anos (DP=6.74). Foram utilizados como instrumentos de avaliação, um questionário sociodemográfico, a Escala de Depressão Geriátrica (GDS) (Pocinho, Farate, Dias, Lee, & Yesavage, 2009) e questões diretas para avaliar a solidão (Paúl, Fonseca, Ribeiro, & Teles, 2006). Os resultados indicam que 26.76% (57) dos indivíduos apresentaram sintomatologia depressiva. Verificaram-se diferenças estatisticamente significativas entre os géneros, níveis de escolaridade, estados civis e condições de vida dos participantes. Relativamente à experiência de solidão, 12.7% (27) dos indivíduos apresentaram solidão. Foram, também, encontradas associações estatisticamente significativas entre a solidão e o género, e o estado civil e as condições de vida dos participantes. Os resultados revelaram uma associação estatisticamente significativa entre a solidão e a sintomatologia depressiva [χ2(2)=35.315; p<0.001)], constatando-se que 35.1% (20) dos participantes apresentam solidão e sintomatologia depressiva. Este estudo alerta para a importância de se perceber a relação entre a solidão e a depressão para que, no desenho de avaliações e intervenções para a velhice, se otimizem as configurações da rede social da pessoa idosa para uma melhoria da sua saúde e qualidade de vida.
Preparation and Properties of Microwave-Absorbing Asphalt Mixtures Containing Graphite and Magnetite Powder
Authors: Wu Shuyin , Yang Jun , Yang Ruochong , Zhu Jipeng , Liu Song 
Published: June 2019

Abstract
The concept of microwave-absorbing asphalt concrete has been proposed to create an asphalt mixture with high microwave heating efficiency. A mixture of 20 % graphite powder and 80 % magnetite powder was used as the microwave-absorbing composite to replace the common mineral filler in asphalt mixtures to improve its microwave absorption capacity. This study aimed to evaluate the effect of proposed absorbent composite on the properties and microwave heating efficiency of asphalt mixtures. The results indicate that the addition of graphite and magnetite powder exhibited an improvement in the microwave heating efficiency of asphalt mixtures. The heating rate of asphalt mastic was improved by more than 10 times, whereas the heating rate of asphalt mixtures containing the absorbent composite was improved by 47.8 %. The pavement performance test results show that the mechanical performances including the dynamic stability, bending strain, residual Marshall stability, and ratio of splitting tensile strength after and before the freeze-thaw cycle satisfy the relevant specification requirements.
Apresentação Dossiê Sexualidades, Intersecções e Mídias
Authors: Balieiro Fernando De Figueiredo , Do Prado Juliana 
Published: June 2019

Nesse Dossiê há artigos que trabalham a partir das interseccionalidades para analisar as mídias e as formas contemporâneas de sexualidade. Os textos que seguem se caracterizam por fazer não apenas isso, mas por trazerem a contribuição de pesquisas que lidam com mídias para analisar aspectos centrais nas relações sociais, como as dimensões da intimidade, afetos, representações, em formas dissidentes à heteronormatividade, a partir de personagens que desafiam, inclusive, os modos como pensamos as relações de poder a partir da influência das mídias.
O desejo pela branquitude e o fantasma das diferenças raciais: negociações das diferenças a partir do uso dos bate-papos na cidade de São Carlos
Authors: Kurashige Keith Diego 
Published: June 2019

Este artigo apresenta alguns resultados da minha pesquisa de mestrado, que envolveu usuários de um site de relacionamento em uma cidade média do interior paulista. Desenvolvido em 2012 a 2014, a investigação procurou compreender como homens, que buscam se relacionar homoeroticamente em segredo, negociam as suas diferenças sociais, em especial a “raça”, nos bate-papos voltados para o público da cidade de São Carlos-SP. Foram feitas observações da plataforma e também interações (que articularam as esferas interdependentes on /off-line) com os usuários, a fim de entender como estes fazem o uso das mídias digitais e negociam os seus desejos. Embora seja datada, esta pesquisa apresenta dados importantes que contribuem para entender como está se dando o uso dos bate-papos em um contexto localizado e também mostra como a gramática erótica deve ser compreendida em sua heterogeneidade e de modo contextual. Levando em consideração as especificidades do contexto são-carlense, o artigo mostra que os usuários do bate-papo refletem ideais de branquitude e os fantasmas das diferenças racializadas constituídas historicamente que fundamentam as suas buscasdesejantes.Palavras-chave: Mídias Digitais; Diferenças; Negociações.