bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical application value of mixed reality in robotic laparoscopic partial nephrectomy
Authors: Zou Xin Chang , Xu Xiang Da , Huang Jian Biao , Chao Hai Chao , Zeng Tao 
Published: November 2024

PurposeRobot-assisted laparoscopic partial nephrectomy (RAPN) has become a key technology in the treatment of renal tumors. Effective preoperative planning and precise intraoperative navigation are critical to a successful surgical outcome. This study aimed to evaluate the clinical application value of mixed reality (MR) in robotic nephron-sparing partial nephrectomy for patients with renal tumors of different complexity based on the R.E.N.A.L. score.Patients and methodsA retrospective analysis was conducted on 68 eligible patients with renal cancer who underwent RAPN at The Second Affiliated Hospital of Nanchang University from January 2021 to December 2023, with postoperative pathology confirmation. Patients were divided into two groups: the MR group, with 28 cases, and the traditional imaging (control) group, with 40 cases. All patients underwent mid-abdominal CT plain scans and enhancements. The MR group utilized three-dimensional reconstruction of CT data and employed 3D tablets and HoloLens glasses for preoperative discussions, surgical planning, and intraoperative guidance. Collect clinical data and metrics to assess surgical outcomes, as well as evaluate performance in areas such as preoperative discussions, doctor-patient communication, surgical planning, and intraoperative navigation.ResultsCompared to robot-assisted partial nephrectomy in the control group, the MR group experienced a reduction in operation time by approximately 30 min [(135.89 ± 23.494) min vs. (165.00 ± 34.320) min, P&lt; 0.001)] and a decrease in ischemia time by around 2.5 min [(20.36 ± 3.956) min vs. (23.80± 6.889) min, P = 0.02)]. Within the subgroup with a R.E.N.A.L. score of less than 7 points, the MR group only showed a significant reduction in operation time [(134.55 ± 150.190) min vs. (150.19 ± 28.638) min, P = 0.045], with no notable differences in other parameters. For the subgroup with a R.E.N.A.L. score of 7 points or higher, the MR group exhibited shorter operation time [(140.83 ± 25.183) min vs. (195.77 ± 23.080) min, P&lt; 0.001] and reduced warm ischemia time [(21.17 ± 2.714) min vs. (28.85 ± 7.570) min, P = 0.029]. Additionally, there was less estimated blood loss [(53.33 ± 5.164) min vs. (114.62 ± 80.376) min, P = 0.018]. All patients had negative resection margins, indicating equivalent therapeutic outcomes between the two groups.ConclusionIn comparison to traditional RAPN, MR technology demonstrates the ability to decrease operation time and warm ischemia time all the while maintaining equivalent curative outcomes. Additionally, it enhances preoperative discussions, doctor-patient interactions, preoperative strategizing, and intraoperative navigation, particularly excelling in complex renal tumor cases of RAPN, where its benefits are most pronounced.
Tinosporae Radix attenuates acute pharyngitis by regulating glycerophospholipid metabolism and inflammatory responses through PI3K-Akt signaling pathway
Authors: Lu Lijie , Huang Chengfeng , Zhou Yongfeng , Jiang Huajuan , Chen Cuiping , Du Jinyu , Zhou Tao , Wen Feiyan , Pei Jin , Wu Qinghua 
Published: November 2024

IntroductionWith the onset of the COVID-19 pandemic, the incidence and prevalence of acute pharyngitis (AP) have increased significantly. Tinosporae Radix (TR) is a vital medication utilized in the treatment of pharyngeal and laryngeal ailments, especially AP. The study endeavors to explore unclear molecular mechanisms of TR in addressing AP.MethodsNetwork pharmacology and metabolomics analyses of effect of TR on AP were conducted, and apossible pathway was validated both in vivo using the acute pharyngitis rat model and in vitro using the LPS-induced RAW264.7 cells model, through techniques such as histopathological examinations, immunohistochemical technology, ELISA, RT-qPCR, and Western blotting to systematically explore the possible mechanisms underlying the inhibition of AP by TR.Results and discussionNetwork pharmacology analysis identified several key targets, including PIK3CA, IL6, AKT1, TNF, and PTGS2, alongside pivotal signaling pathways such as IL-17, TNF, Hepatitis B, nuclear factor kappa B (NF-κB), Influenza A, and the PI3K-Akt pathway. Most of them are closely associated with inflammation. Then, wide-target metabolomics analysis showed that TR downregulated substances within the glycerophospholipid metabolic pathway, and modulated the PI3K-Akt pathway. The integrated findings from network pharmacology and metabolomics underscored the pivotal role of the PI3K-Akt signaling pathway and the attenuation of inflammatory responses. Finally, in vitro and in vivo experiments have shown that TR can inhibit inflammatory factors such as IL-6, TNF - α, and COX-2, downregulate targets such as PI3K and AKT on the PI3K-Akt signaling pathway, and thereby alleviate the inflammatory response of AP. Our study demonstrated that TR exerts an anti-AP effect through suppression of release of inflammatory factors and modulation of glycerophospholipid metabolism via suppressing the PI3K-Akt signaling pathway.
Do government environmental audits reduce air pollution? Evidence obtained from Lanzhou
Authors: Chen Tianyou , Li Ji 
Published: November 2024

IntroductionThis study investigates the effectiveness of government environmental audits in mitigating air pollution. Specifically, it focuses on a pilot project conducted in Lanzhou City by the former Ministry of Environmental Protection. The research employs a regression discontinuity design to empirically assess the impact of these audits on air quality.MethodsThe study utilizes a regression discontinuity design to evaluate the impact of the government environmental audits. The primary outcome variable is the Air Quality Index (AQI). The analysis includes extensive robustness checks, such as sensitivity testing for optimal bandwidths of key pollutants, adjusting for precipitation levels, and conducting various robustness tests to ensure the reliability of the results.ResultsThe findings reveal a significant decline in the AQI following the implementation of the environmental audits. The AQI decreased from 31 to 25 during and after the audit period. Additionally, the study observed a notable increase in precipitation levels, suggesting potential environmental improvements. Robustness tests further confirm the reliability of the regression results.DiscussionThe research outcomes demonstrate the effectiveness of government environmental audits in reducing air pollution. By supervising local governments in the implementation of environmental protection policies, these audits contribute to improved air quality. The findings highlight the importance of targeted interventions and policy enforcement in addressing environmental challenges.
Overexpression of the Kiwifruit Transcription Factor AaMYB44 Decreases the Cold Tolerance in Arabidopsis thaliana
Authors: Li Yihang , Lin Miaomiao , Zhang Qina , Zhang Peng , Zhang Zhenzhen , Li Yukuo , Sun Leiming , Li Sumei , Li Congcong , Chen Dixin , Qi Xiujuan 
Published: November 2024

Cold stress is one of the main abiotic stresses that affect the development and growth of kiwifruit (Actinidia arguta). Herein, we analyzed the transcriptomic data of A. arguta dormant shoots in response to low-temperature treatment, identified 52 MYB genes, and constructed a phylogenetic tree based on the encoded protein sequences. Then, the effect of one MYB gene on cold tolerance was analyzed. This gene had an open reading frame of 837 bp long and encoded 279 amino acids. Sequence alignment and phylogenetic analysis revealed that this gene belongs to the R2R3-MYB family and was named AaMYB44 based on its homology to other MYB family members. Quantitative real-time PCR revealed that AaMYB44 expression was significantly induced by low temperatures but exhibited the opposite trend in cold-tolerant genotypes. Subcellular localization assays revealed the nuclear localization of the AaMYB44 protein. Furthermore, AaMYB44 was transformed into Arabidopsis thaliana (A. thaliana) via inflorescence infection, and physiological and biochemical tests revealed that the cold resistance and antioxidant capacity of the transgenic A. thaliana were lower than those of wild-type plants. Overall, AaMYB44 might play a negative regulatory role in response to cold stress, providing new insight into the mechanism of cold tolerance.
Primary care performance in a Ugandan rural district: cross-sectional descriptive study
Authors: Besigye Innocent Kabahena , Mash Robert James 
Published: November 2024

BackgroundTo strengthen primary health care (PHC), there is a need to measure its performance.AimTo measure primary care performance in one rural Ugandan district.Design and study settingA cross-sectional survey of Tororo District administered the Primary Care Assessment Tool (PCAT) across a sample of 51 facilities. There were four levels of health facilities (health centres II to general hospital).MethodRandom sample of 100 users was obtained from each level while including all primary care providers and managers. Data was collected in REDCap software, and analysed using Statistical Package for Social Sciences vs23.ResultsOnly 35.1% of users had a strong affiliation with their PHC facility. Overall primary care score suggested that performance was acceptable to the majority of users (58.9% rating performance at least acceptable). Ongoing care was rated by users as very poor (<25% of people rating it at least acceptable). Comprehensiveness (services available) was rated poor by users (<50% finding it at least acceptable). Users rated first contact access and coordination (information systems) acceptable (51-75% finding them at least acceptable). Person-centredness and comprehensiveness (services provided) were rated good by users (>75% rating them as acceptable or more). Providers and users differed significantly in their scoring across all domains, with providers usually more positive. Performance significantly improved as the PHC level increased.ConclusionPrimary care performance in the study district was sub-optimal. The PCAT identified primary care functions that needed improving and may be a useful tool to measure PHC performance across the region.
Analisis Preferensi Konsumen terhadap Produk Beras di Pasar Baru Cikarang Kabupaten Bekasi
Authors: Adriyan Fikri , Azzahra Fatimah , Mahatmayana I Ketut Manu 
Published: November 2024

Consumer preference for a product is based on utility and importance value. Consumers of rice in the Pasar Baru Cikarang rarely choose the attribute and levels of the rice product is the color, hygiene, type, aroma, and price. The purpose of this research is to analyze the usefulness of consumer preferences and the importance of consumer preference in choosing rice products in Pasar Baru Cikarang Kabupaten Bekasi with the time of research from May to June. The method used in this study is quantitative methods and descriptive methods. Data analysis used is conjoin analysis. Determination of respondents using accidental sampling technique, with a total of 100 respondents. The results of this study show that of the total respondents, the combination of products in choosing rice products that are useful to the preference of consumer and interests to consumer preference is color with clear white, hygiene without fleas, type of pulen, aroma of fragrance, and price of Rp10.000/kg – Rp12.000/kg. In choosing a rice product, the sequence of the most important attribute that influence consumer purchase is the first color attribute with a presentation of 45.32%, the second price atribut with a persentage of 16.61%, the third aroma attribute with a persentage of 15.61%, four hygienic atribut with a persentage of 15,52% and the last is the type attribute with a persentage of 7.34%.
Pay Later dan Perilaku Impulse Buying di Era Industri 4.0
Authors: Irin Mirrah Luthfia  , Mona Inayah Pratiwi  , Destine Fajar Wiedayanti  , Ana Putri Nastiti  
Published: November 2024

Pay later services play an important role in the era of Industry 4.0 by bringing flexibility and integrated payment convenience with the development of digital technology. The advantages and convenience offered by pay later are very appealing. Impulse buying, which refers to the sudden, spontaneous, and unplanned purchase of goods or services, often occurs due to emotional impulses, sudden desires, or external factors such as promotions or discount offers. Pay later technology is well-received by the Indonesian society, and pay later users in Indonesia are categorized as quite high (Sari, 2021). This study employed interview techniques with 10 adult women who have used pay later applications, where 80% of the respondents used the pay later method because of its convenience. The use of pay later can provide flexibility in financial management, especially if used wisely. However, individuals need to carefully consider their budget, understand the requirements and costs associated with pay later services, and limit the tendency for impulsive shopping to avoid getting trapped in an uncontrollable debt cycle.
Abstrak
Layanan Pay later berperan penting dalam era industri 4.0 dengan menghadirkan fleksibilitas dan kemudahan pembayaran yang terintegrasi dengan perkembangan teknologi digital. Keunggulan dan kemudahan yang ditawarkan oleh pay later sangat menarik. Impulse buying atau pembelian impulsif, yang merujuk pada pembelian barang atau layanan yang dilakukan secara tiba-tiba, spontan, dan tanpa perencanaan yang matang, sering kali terjadi karena dorongan emosional, keinginan mendadak, atau rangsangan dari faktor eksternal seperti promosi atau penawaran diskon. Teknologi pay later disambut baik oleh masyarakat Indonesia dan pengguna pay later di Indonesia berada dalam kategori cukup tinggi (Sari, 2021). Penelitian ini menggunakan Teknik wawancara kepada 10 orang wanita dewasa yang telah menggunakan aplikasi pay later dimana 80% responden menggunakan metode pay later karena kemudahannya. Penggunaan Pay later dapat memberikan fleksibilitas dalam pengelolaan keuangan, terutama jika digunakan dengan bijaksana. Namun, individu perlu mempertimbangkan secara hati-hati anggaran mereka, memahami persyaratan dan biaya yang terkait dengan layanan Pay later dan membatasi kecenderungan untuk belanja impulsif agar tidak terjebak dalam siklus hutang yang tidak terkendali.
ANALYSIS OF THE CORRELATION BETWEEN BUSINESS ECOSYSTEM AND ENTERPRISE PERFORMANCE UNDER THE BACKGROUND OF DIGITAL TRANSFORMATION
Authors: Wang Wei , Tong Zelin 
Published: November 2024

This study, grounded in the theory of the business ecosystem, investigates how the digital capabilities of Chinese high-tech manufacturing enterprises influence corporate performance. The study builds a chain effect model of "digital capabilities—value co-creation—network capabilities—corporate performance" and looks at how environmental uncertainty affects the model. We looked at Chinese high-tech manufacturing companies through a questionnaire survey and in-depth analysis. The study found that: (1) digital capabilities greatly enhance corporate performance through the mediating role of value co-creation and network capabilities; (2) environmental uncertainty has a moderating effect on the relationship between digital capabilities and corporate performance. This study enriches theoretical research on the relationship between digital transformation and corporate performance, providing theoretical guidance and practical inspiration for Chinese high-tech manufacturing enterprises to enhance their competitiveness in the digital economy era.
A STUDY OF THE IMPACT OF SERVICE QUALITY ON CUSTOMER REVISIT INTENTION OF PSYCHOLOGICAL SERVICE COMPANIES: USING CUSTOMER EXPERIENCE AND DISEASE AWARENESS AS MEDIATING VARIABLES
Authors: Zheng Yi 
Published: November 2024

In today's society, mental health issues are receiving increasing attention, and numerous psychological service companies have emerged as providers of professional mental health services. However, the market competition is also becoming more intense, making service quality a crucial factor for psychological enterprises to achieve long-term development and customer loyalty. This study aims to explore the specific mechanisms by which various elements of service quality, such as accessibility, convenience, reliability, and efficiency, affect clients' willingness to revisit psychological consulting firms. Through empirical analysis, the study seeks to clarify the degree of association between different service quality dimensions and the intention to revisit and analyze their internal relationships. Therefore, the study will survey clients who have received psychological counseling and therapy services, using client experience and disease perception as mediating variables to examine the impact of service quality on the revisit intention of customers in psychological service enterprises. Additionally, through an in-depth study of the YM Psychological Counselor Training Company, the research will analyze issues related to the company's low revisit intention and propose recommendations for adjustment, offering a reference for similar enterprises.
CHALLENGE IN TREATING OPTIC NEURITIS IN PATIENT WITH CEREBRAL TOXOPLASMOSIS RELATED TO IMMUNOCOMPROMISED CONDITION
Authors: Latifah Latifah , Vierla Wino Vrieda 
Published: November 2024

Introduction: This study aimed to discuss the prognosis of optic neuritis in a patient with cerebral toxoplasmosis related to an immunocompromised condition.
Case Report: A 28-year-old female complained of blurred vision and double vision 2 weeks before admission, accompanied by headache, low extremities weakness, dysphonia, and dysphagia. Visual acuity of both eyes was 6/30 and worsened to 6/60 in a couple of days. Anterior segment examination revealed anisocoria pupil, and RAPD was positive in the left eye. Funduscopic examination showed a blurry margin and hyperemia of the optic nerve head. There was impaired eye movement, indicating oculomotor and abducens nerve palsies. High titer of IgG Antibody Toxoplasma (264) and very low titer of CD4 (<50) with non-reactive HIV rapid test were found in laboratory findings. Multiple ring enhancement was shown in MRI finding. Unfortunately, patient passed away during hospitalization due to respiratory failure.
Discussion: Toxoplasmosis-associated optic neuritis is rare and usually becomes potentially serious. Although parasite detection by microscopy and bioassay is considered the gold standard for the diagnosis of toxoplasmosis, clinical diagnosis relies more on serological examination methods. The high proportion of deaths from this disease is mostly caused by late diagnosis of the infection.
Conclusion: Optic neuritis that accompanied by systemic disorders needs special attention and comprehensive treatment among multidisciplinary divisions, especially in the immunocompromised condition. Early detection and primary prevention are important to improve prognosis and survival rate.
The University as a catalyst in the processes of Adult Continuing Education (ACE)
Authors: Bonometti Stefano , Ferri Letizia 
Published: November 2024

The article analyzes the cooperation between university researchers and local stakeholders in promoting adult continuing education (ACE) through action research. It outlines four projects conducted at the Chair of Pedagogy at the University of Insubria, through which innovative solutions have been developed in various sectors using research and social learning methodologies. The RE-START project involved establishing community tables at the local level, the Adolescent Tables of the Municipality of Varese were structured according to the Change Laboratory logic, the Morselli Project implemented a Service Learning approach in collaboration with local schools, and vertical Communities of Practice were developed for the co-construction of school guidance modules with secondary schools. In all these projects, the University positioned itself as a catalyst and activator of the agency of the adults with whom it collaborated and co-designed.

Il ruolo dell’Università come catalizzatore nei processi di Educazione Continua per Adulti (ECA).
L’articolo analizza la cooperazione tra ricercatori universitari e operatori territoriali nel promuovere l’educazione continua per adulti (ECA) attraverso la ricerca-azione. Si delineano quattro progetti condotti presso la cattedra di Pedagogia dell’Università degli Studi dell’Insubria, attraverso i quali sono state costruite soluzioni innovative in diversi settori tramite metodologie di ricerca e apprendimento sociale. Il progetto RE-START ha visto l’istituzione di tavoli di comunità a livello locale, i Tavoli Adolescenti del Comune di Varese sono stati articolati secondo la logica del Change Laboratory, il Progetto Morselli ha implementato un approccio di Service Learning in collaborazione con le istituzioni e le scuole locali, sono state sviluppate Comunità di Pratica verticali per la co-costruzione di moduli di orientamento scolastico con le scuole secondarie. In tutti questi progetti l’Università si è posta come lievito ed attivatore dell’agency degli adulti con cui ha collaborato e co-progettato.
The future of thinking in the digital age
Authors: Michelini Maria-Chiara 
Published: November 2024

This paper deals with the future of thinking in the light of the increasing and widespread irruption of Artificial Intelligence. In this sense, it will investigate the ways in which this impact is realized and some potential long-term effects on the way of thinking, emphasizing the ethical dimensions involved. It will highlight the need for a refined and shared reflection in view of the human project to which AI and consequent AI design strategies should be oriented. Within this framework, it will show the responsibility and the peculiar competence of pedagogy in identifying some formative perspectives, deemed necessary to ensure the future of the best form of thinking.

Il futuro del pensiero nell’era digitale.
Il presente contributo affronta il tema del futuro del pensiero alla luce della crescente e capillare irruzione dell’Intelligenza Artificiale. In tal senso, indagherà le forme con cui tale impatto si realizza e alcuni potenziali effetti nel lungo periodo sul modo di pensare, sottolineando dimensioni etiche implicate. Evidenzierà la necessità di una riflessione raffinata e condivisa in vista del progetto umano al quale orientare l’IA e le conseguenti strategie di design dell’IA. Entro questa cornice, mostrerà la responsabilità e la peculiare competenza della pedagogia nell’individuare alcune prospettive formative, ritenute necessarie per assicurare il futuro della miglior forma di pensiero.