bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrafast and highly sensitive infrared photodetectors based on two-dimensional oxyselenide crystals
Authors: Yin Jianbo , Tan Zhenjun , Hong Hao , Wu Jinxiong , Yuan Hongtao , Liu Yujing , Chen Cheng , Tan Congwei , Yao Fengrui , Li Tianran , Chen Yulin , Liu Zhongfan , Liu Kaihui , Peng Hailin 
Published: August 2018

AbstractInfrared light detection and sensing is deeply embedded in modern technology and human society and its development has always been benefitting from the discovery of various photoelectric materials. The rise of two-dimensional materials, thanks to their distinct electronic structures, extreme dimensional confinement and strong light–matter interactions, provides a material platform for next-generation infrared photodetection. Ideal infrared detectors should have fast respond, high sensitivity and air-stability, which are rare to meet at the same time in one two-dimensional material. Herein we demonstrate an infrared photodetector based on two-dimensional Bi2O2Se crystal, whose main characteristics are outstanding in the whole two-dimensional family: high sensitivity of 65 AW−1 at 1200 nm and ultrafast photoresponse of ~1 ps at room temperature, implying an intrinsic material-limited bandwidth up to 500 GHz. Such great performance is attributed to the suitable electronic bandgap and high carrier mobility of two-dimensional oxyselenide.
Large networks of rational agents form persistent echo chambers
Authors: Madsen Jens Koed , Bailey Richard M , Pilditch Toby D. 
Published: August 2018

AbstractEcho chambers (ECs) are enclosed epistemic circles where like-minded people communicate and reinforce pre-existing beliefs. It remains unclear if cognitive errors are necessarily required for ECs to emerge, and then how ECs are able to persist in networks with available contrary information. We show that ECs can theoretically emerge amongst error-free Bayesian agents, and that larger networks encourage rather than ameliorate EC growth. This suggests that the network structure itself contributes to echo chamber formation. While cognitive and social biases might exacerbate EC emergence, they are not necessary conditions. In line with this, we test stylized interventions to reduce EC formation, finding that system-wide truthful ‘educational’ broadcasts ameliorate the effect, but do not remove it entirely. Such interventions are shown to be more effective on agents newer to the network. Critically, this work serves as a formal argument for the responsibility of system architects in mitigating EC formation and retention.
A centuries-long delay between a paleo-ice-shelf collapse and grounding-line retreat in the Whales Deep Basin, eastern Ross Sea, Antarctica
Authors: Bart Philip J. , DeCesare Matthew , Rosenheim Brad E. , Majewski Wojceich , McGlannan Austin 
Published: August 2018

AbstractRecent thinning and loss of Antarctic ice shelves has been followed by near synchronous acceleration of ice flow that may eventually lead to sustained deflation and significant contraction in the extent of grounded and floating ice. Here, we present radiocarbon dates from foraminifera that constrain the time elapsed between a previously described paleo-ice-shelf collapse and the subsequent major grounding-line retreat in the Whales Deep Basin (WDB) of eastern Ross Sea. The dates indicate that West Antarctic Ice Sheet (WAIS) grounding-line retreat from the continental shelf edge was underway prior to 14.7 ± 0.4 cal kyr BP. A paleo-ice-shelf collapse occurred at 12.3 ± 0.2 cal kyr BP. The grounding position was maintained on the outer-continental shelf until at least 11.5 ± 0.3 cal kyr BP before experiencing a 200-km retreat. Given the age uncertainties, the major grounding-line retreat lagged ice-shelf collapse by at least two centuries and by as much as fourteen centuries. In the WDB, the centuries-long delay in the retreat of grounded ice was partly due to rapid aggradational stacking of an unusually large volume of grounding-zone-wedge sediment as ice-stream discharge accelerated following ice-shelf collapse. This new deglacial reconstruction shows that ongoing changes to ice shelves may trigger complex dynamics whose consequences are realized only after a significant lag.
Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison
Authors: Glauche Ingmar , Kuhn Matthias , Baldow Christoph , Schulze Philipp , Rothe Tino , Liebscher Hendrik , Roy Amit , Wang Xiaoning , Roeder Ingo 
Published: August 2018

AbstractLongitudinal monitoring of BCR-ABL transcript levels in peripheral blood of CML patients treated with tyrosine kinase inhibitors (TKI) revealed a typical biphasic response. Although second generation TKIs like dasatinib proved more efficient in achieving molecular remission compared to first generation TKI imatinib, it is unclear how individual responses differ between the drugs and whether mechanisms of drug action can be deduced from the dynamic data. We use time courses from the DASISION trial to address statistical differences in the dynamic response between first line imatinib vs. dasatinib treatment cohorts and we analyze differences between the cohorts by fitting an established mathematical model of functional CML treatment to individual time courses. On average, dasatinib-treated patients show a steeper initial response, while the long-term response only marginally differed between the treatments. Supplementing each patient time course with a corresponding confidence region, we illustrate the consequences of the uncertainty estimate for the underlying mechanisms of CML remission. Our model suggests that the observed BCR-ABL dynamics may result from different, underlying stem cell dynamics. These results illustrate that the perception and description of CML treatment response as a dynamic process on the level of individual patients is a prerequisite for reliable patient-specific response predictions and treatment optimizations.
Patterns of early primary school-based literacy interventions among Pacific children from a nationwide health screening programme of 4 year olds
Authors: Schluter Philip J. , Kokaua Jesse , Tautolo El-Shadan , Richards Rosalina , Taleni Tufulasi , Kim Hyun M. , Audas Richard , McNeill Brigid , Taylor Barry , Gillon Gail 
Published: August 2018

AbstractLiteracy success is critical to unlocking a child’s potential and enhancing their future wellbeing. Thus, the early identification and redressing of literacy needs is vital. Pacific children have, on average, the lowest literacy achievement levels in New Zealand. However, this population is very diverse. This study sought to determine whether the current national health screening programme of pre-school children could be used as an early detection tool of Pacific children with the greatest literacy needs. Time-to-event analyses of literacy intervention data for Pacific children born in years 2005–2011 were employed. A multivariable Cox proportional hazard model was fitted, and predictive assessment made using training and test datasets. Overall, 59,760 Pacific children were included, with 6,861 (11.5%) receiving at least one literacy intervention. Tongan (hazard ratio [HR]: 1.33; 95% confidence interval [CI]: 1.23, 1.45) and Cook Island Māori (HR: 1.33; 95% CI: 1.21, 1.47) children were more likely to receive an intervention than Samoan children; whereas those children with both Pacific and non-Pacific ethnic identifications were less likely. However, the multivariable model lacked reasonable predictive power (Harrell’s c-statistic: 0.592; 95% CI: 0.583, 0.602). Regardless, important Pacific sub-populations emerged who would benefit from targeted literacy intervention or policy implementation.
3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration
Authors: Kim Ji Hyun , Seol Young-Joon , Ko In Kap , Kang Hyun-Wook , Lee Young Koo , Yoo James J. , Atala Anthony , Lee Sang Jin 
Published: August 2018

AbstractA bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which mimics the structural and functional characteristics of the native tissue, is needed for reconstructive surgery. Rapid progress in the cell-based tissue engineering principle has enabled in vitro creation of cellularized muscle-like constructs; however, the current fabrication methods are still limited to build a three-dimensional (3D) muscle construct with a highly viable, organized cellular structure with the potential for a future human trial. Here, we applied 3D bioprinting strategy to fabricate an implantable, bioengineered skeletal muscle tissue composed of human primary muscle progenitor cells (hMPCs). The bioprinted skeletal muscle tissue showed a highly organized multi-layered muscle bundle made by viable, densely packed, and aligned myofiber-like structures. Our in vivo study presented that the bioprinted muscle constructs reached 82% of functional recovery in a rodent model of tibialis anterior (TA) muscle defect at 8 weeks of post-implantation. In addition, histological and immunohistological examinations indicated that the bioprinted muscle constructs were well integrated with host vascular and neural networks. We demonstrated the potential of the use of the 3D bioprinted skeletal muscle with a spatially organized structure that can reconstruct the extensive muscle defects.
Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
Authors: Clemente Nicolina , Abdine Alaa , Ubarretxena-Belandia Iban , Wang Chunyu 
Published: August 2018

AbstractIntramembrane-cleaving proteases (I-CLiPs) play crucial roles in physiological and pathological processes, such as Alzheimer’s disease and cancer. However, the mechanisms of substrate recognition by I-CLiPs remain poorly understood. The aspartic I-CLiP presenilin is the catalytic subunit of the γ-secretase complex, which releases the amyloid-β peptides (Aβs) through intramembrane proteolysis of the transmembrane domain of the amyloid precursor protein (APPTM). Here we used solution NMR to probe substrate docking of APPTM to the presenilin homologs (PSHs) MCMJR1 and MAMRE50, which cleaved APPTM in the NMR tube. Chemical shift perturbation (CSP) showed juxtamembrane regions of APPTM mediate its docking to MCMJR1. Binding of the substrate to I-CLiP decreased the magnitude of amide proton chemical shifts δH at the C-terminal half of the substrate APPTM, indicating that the docking to the enzyme weakens helical hydrogen bonds and unwinds the substrate transmembrane helix around the initial ε-cleavage site. The APPTM V44M substitution linked to familial AD caused more CSP and helical unwinding around the ε-cleavage site. MAMRE50, which cleaved APPTM at a higher rate, also caused more CSP and helical unwinding in APPTM than MCMJR1. Our data suggest that docking of the substrate transmembrane helix and helical unwinding is coupled in intramembrane proteolysis and FAD mutation modifies enzyme/substrate interaction, providing novel insights into the mechanisms of I-CLiPs and AD drug discovery.
Invasive meningococcal disease in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation
Authors: Chen Mingliang , Rodrigues Charlene M. C. , Harrison Odile B. , Zhang Chi , Tan Tian , Chen Jian , Zhang Xi , Chen Min , Maiden Martin C. J. 
Published: August 2018

AbstractSerogroup B invasive meningococcal disease (IMD) is increasing in China, but little is known about the causative meningococci. Here, IMD and carriage isolates in Shanghai characterised and the applicability of different vaccines assessed. Seven IMD epidemic periods have been observed in Shanghai since 1950, with 460 isolates collected including 169 from IMD and 291 from carriage. Analyses were divided according to the period of meningococcal polysaccharide vaccine (MPV) introduction: (i) pre-MPV-A, 1965–1980; (ii) post-MPV-A, 1981–2008; and (iii) post-MPV-A + C, 2009–2016. Over this period, IMD incidence decreased from 55.4/100,000 to 0.71 then to 0.02, corresponding to successive changes in meningococcal type from serogroup A ST-5 complex (MenA:cc5) to MenC:cc4821, and finally MenB:cc4821. MenB IMD became predominant (63.2%) in the post-MPV-A + C period, and 50% of cases were caused by cc4821, with the highest incidence in infants (0.45/100,000) and a case-fatality rate of 9.5%. IMD was positively correlated with population carriage rates. Using the Bexsero Antigen Sequence Type (BAST) system, fewer than 25% of MenB isolates in the post-MPV-A + C period contained exact or predicted cross reactive matches to the vaccines Bexsero, Trumenba, or an outer membrane vesicle (OMV)-based vaccine, NonaMen. A unique IMD epidemiology was seen in China, changing periodically from epidemic to hyperepidemic and low-level endemic disease. At the time of writing, MenB IMD dominated IMD in Shanghai, with isolates potentially beyond coverage with licenced OMV- and protein-based MenB vaccines.
AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation
Authors: Bretin Alexis , Lucas Cécily , Larabi Anaïs , Dalmasso Guillaume , Billard Elisabeth , Barnich Nicolas , Bonnet Richard , Nguyen Hang Thi Thu 
Published: August 2018

AbstractA high prevalence of adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn’s disease patients has been shown. AIEC colonize the intestine and induce inflammation in genetically predisposed mouse models including CEABAC10 transgenic (Tg) mice expressing human CEACAM6-receptor for AIEC and eif2ak4−/− mice exhibiting autophagy defect in response to AIEC infection. Here, we aimed at investigating whether gut microbiota modification contributes to AIEC-induced intestinal inflammation in these mouse models. For this, eif2ak4+/+ and eif2ak4−/− mice or CEABAC10 Tg mice invalidated for Eif2ak4 gene (Tg/eif2ak4−/−) or not (Tg/eif2ak4+/+) were infected with the AIEC reference strain LF82 or the non-pathogenic E. coli K12 MG1655 strain. In all mouse groups, LF82 colonized the gut better and longer than MG1655. No difference in fecal microbiota composition was observed in eif2ak4+/+ and eif2ak4−/− mice before infection and at day 1 and 4 post-infection. LF82-infected eif2ak4−/− mice exhibited altered fecal microbiota composition at day 14 and 21 post-infection and increased fecal lipocalin-2 level at day 21 post-infection compared to other groups, indicating that intestinal inflammation developed after microbiota modification. Similar results were obtained for LF82-infected Tg/eif2ak4−/− mice. These results suggest that in genetically predisposed hosts, AIEC colonization might induce chronic intestinal inflammation by altering the gut microbiota composition.
A 200-year annually laminated stalagmite record of precipitation seasonality in southeastern China and its linkages to ENSO and PDO
Authors: Zhang Haiwei , Cheng Hai , Spötl Christoph , Cai Yanjun , Sinha Ashish , Tan Liangcheng , Yi Liang , Yan Hong , Kathayat Gayatri , Ning Youfeng , Li Xianglei , Zhang Fan , Zhao Jingyao , Edwards R. Lawrence 
Published: August 2018

AbstractIn southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for the interval 1810–2009 AD from E’mei cave, Jiangxi Province, SEC. The comparison between δ18Os and instrumental data indicates that the δ18Os variability is primarily controlled by the precipitation seasonality (i.e., the ratio of EASM/NSM precipitation) modulated by the El Niño/Southern Oscillation (ENSO) on interannual to interdecadal timescales. Higher (lower) δ18Os values thereby correspond to lower (higher) EASM/NSM ratios associated with El Niño (La Niña) events. Significant correlations with ENSO and the Pacific Decadal Oscillation (PDO) indicate that the precipitation seasonality in SEC is remarkably influenced by ocean-atmosphere interactions, with lower (higher) EASM/NSM ratios during warm (cold) phases of ENSO/PDO. The progressive increase in δ18Os since 2005 AD may reflect a strengthening of the central Pacific El Niño under continued anthropogenic global warming. The relationship between seasonal precipitation and δ18Os with ENSO/PDO requires further studies.
Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease
Authors: Solopchuk Oleg , Sebti Moustapha , Bouvy Céline , Benoit Charles-Etienne , Warlop Thibault , Jeanjean Anne , Zénon Alexandre 
Published: August 2018

AbstractFatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson’s disease (PD). Earlier studies have examined the role of dopamine and serotonin in pathogenesis of fatigue, but the plausible role of noradrenalin (NA) remains underexplored. We investigated the relationship between fatigue in Parkinsonian patients and the extent of degeneration of Locus Coeruleus (LC), the main source of NA in the brain. We quantified LC and Substantia Nigra (SN) atrophy using neuromelanin-sensitive imaging, analyzed with a novel, fully automated algorithm. We also assessed patients’ fatigue, depression, sleep disturbance and vigilance. We found that LC degeneration correlated with the levels of depression and vigilance but not with fatigue, while fatigue correlated weakly with atrophy of SN. These results indicate that LC degeneration in Parkinson’s disease is unlikely to cause fatigue, but may be involved in mood and vigilance alterations.
Oral Delivery of a DNA Vaccine Expressing the PrM and E Genes: A Promising Vaccine Strategy against Flavivirus in Ducks
Authors: Huang Juan , Jia Renyong , Shen Haoyue , Wang Mingshu , Zhu Dekang , Chen Shun , Liu Mafeng , Zhao Xinxin , Wu Ying , Yang Qiao , Yin Zhongqiong , Cheng Anchun 
Published: August 2018

AbstractA flavivirus, named duck tembusu virus (DTMUV), emerged in China in 2010. This virus has caused great economic losses in the poultry industry in China and may pose a threat to public health. As a safe, efficient and convenient vaccine development strategy, DNA-based vaccines have become a popular approach for both human and veterinary applications. Attenuated bacteria have been widely used as vehicles to deliver heterologous antigens to the immune system. Thus, an efficient and low-cost oral delivery DNA vaccine SL7207 (pVAX1-SME) based on envelope proteins (prM and E) of DTMUV and attenuated Salmonella typhimurium aroA- strain SL7207 was developed and evaluated in this study. The prM and E antigen proteins were successfully expressed from the vaccine SL7207 (pVAX1-SME) both in vitro and in vivo. High titers of the specific antibody against the DTMUV-E protein and the neutralizing antibody against the DTMUV virus were both detected after vaccination with SL7207 (pVAX1-SME). Ducks orally vaccinated with the SL7207 (pVAX-SME) vaccine were efficiently protected from lethal DTMUV infection in this study. Taken together, we demonstrated that prM and E proteins of DTMUV possess strong immunogenicity against the DTMUV infection. Moreover, an oral delivery of the DNA vaccine SL7207 (pVAX1-SME) utilizing Salmonella SL7207 was an efficient way to protect the ducks against DTMUV infection and provides an economic and fast vaccine delivery strategy for a large-scale clinical use.
Subwavelength Interferometric Control of Absorption in Three-port Acoustic Network
Authors: Richoux O. , Achilleos V. , Theocharis G. , Brouzos I. 
Published: August 2018

AbstractUtilizing the effect of losses, we show that symmetric 3-port devices exhibit coherent perfect absorption of waves and we provide the corresponding conditions on the reflection and transmission coefficients. Infinite combinations of asymmetric inputs with different amplitudes and phase at each port as well as a completely symmetric input, are found to be perfectly absorbed. To illustrate the above we study an acoustic 3-port network operating in a subwavelength frequency both theoretically and experimentally. In addition we show how the output from a 3-port network is altered, when conditions of perfect absorption are met but the input waves phase and amplitude vary. In that regard, we propose optimized structures which feature both perfect absorption and perfect transmission at the same frequency by tuning the amplitudes and phases of the input waves.
Hyperuricemia is associated with atrial fibrillation prevalence in very elderly - a community based study in Chengdu, China
Authors: Huang Gang , Xu Rong-hua , Xu Jun-bo , liu Ya , Liu Zhao-hui , Xie Xue , Zhang Ting-jie 
Published: August 2018

AbstractHyperuricemia is a risk factor for cardiovascular diseases. However, in very elderly, the relationship between hyperuricemia and the prevalence of atrial fibrillation (AF) is not clear. This study aimed to investigate hyperuricemia and the risk of AF in community very elderly. In this cross-sectional study, 1056 very elderly in community were enrolled. Serum uric acid (SUA) were measured and rest 12-lead electrocardiogram was performed. Multiple logistic regression models were used to explore risk factors for AF in very elderly. Finally, 1038 participants were included in analysis and the mean age of the study participants were 83.6 ± 3.4 years (age range 80–100 years). The mean SUA level was 350.1 ± 84.5 µmol/L. The estimated prevalence of AF was 5.3%, and there was no significant sex difference (5.8% for men and 4.8% for women, p = 0.401). Multiple logistic regression found that participants with hyperuricemia (SUA >416 µmol/L in men and >357 µmol/L in women) had a higher risk (odds ratio: 2.080, 95% confidence interval: 1.103–4.202, P = 0.007) of suffering AF in very elderly Chinese. In conclusion, AF is relatively frequent in this community very elderly Chinese in Chengdu. Hyperuricemia is associated with the prevalence of AF in general very elderly.
COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation
Authors: Youn Seock-Won , Lee Hyun-Chae , Lee Sae-Won , Lee Jaewon , Jang Hyunduk , Lee Eun Ju , Kim Hyo-Soo 
Published: August 2018

AbstractAngiopoietin-1 modulates vascular stability via Tie2 on endothelial cells. In our previous study, we also showed it acts as an inhibitor of cardiomyocyte death. However, it remains poorly understood how Ang1 regulates myogenesis during muscle regeneration. Here we found that COMP-Ang1 (cAng1) enhances muscle regeneration through N-cadherin activation. Muscle fiber regeneration after limb muscle damage by ischemic injury was enhanced with cAng1 treatment. Mechanistically cAng1 directly bound to N-cadherin on the myoblast surface in a Ca2+ dependent manner. The interaction enhanced N-cadherin activation via N-cadherin/p120-catenin complex formation, which in turn activated p38MAPK (but not AKT or ERK) and myogenin expression (but not myoD) as well as increasing myogenin+ cells in/ex vivo. After transplantation of GFP-expressing myoblasts (GFP-MB), we showed an increased generation of GFP+ myotubes with adenovirus cAng1 (Adv-cAng1) injection. Adv-cAng1, however, could not stimulate myotube formation in N-cadherin-depleted GFP-MB. Taken together, this study uncovers the mechanism of how cAng1 promotes myoblast differentiation and muscle regeneration through the N-cadherin/p120-catenin/p38MAPK/myogenin axis.