bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technique of the laparoscopic pelvic exenteration
Authors: Galliamov E. A. , Biktimirov R. G. , Sergeev V. P. , Aminova L. N. , Sanzharov A. E. , Agapov M. A. , Volodin D. I. , Gallyamov Е. E. , Gololobov G. Yu. 
Published: November 2018

Background: Laparoscopic surgery has proved itself to be a “golden standard” for treatment of most abdominal and retroperitoneal cancers. Such a serious procedure as pelvic exenteration continues to be a complex surgical intervention usually performed through a conventional laparotomic access. However, studies on minimally invasive approach for this intervention have becoming increasingly published in the world literature.Aim: To describe the laparoscopic pelvic exenteration technique of pelvic exenteration, as well as to assess short- and long-term results of these interventions.Materials and methods: From 2011 to 2018, 21 procedures of laparoscopic pelvic exenteration have been performed in 6 surgical centers (Moscow, Russia). Six (6) patients had previously confirmed cervical cancer, 7 patients had bladder cancer, 4 patients had rectal cancer, 1 patient had vaginal cancer, 2 patients had relapsing vaginal cancers after previous uterine extirpation, and 1 patient had an ovarian neoplasm.Results: The laparoscopic pelvic exenteration volumes were as follows: 9 total, 7 anterior and 5 posterior procedures. In 19 out of 21 cases, negative resection margin (R0) was possible. Median duration of the procedure was 254 minutes, median blood loss was 515 ml, and median postoperative hospital stay was 13 days. Postoperative complications were registered in 6 (28.6%) patients. The 3-year overall survival was 85.71%.Сonclusion: The choice of laparoscopic access can reduce blood loss, decrease the rates of early postoperative complications, contributes to a more comfortable postoperative period with early activation and less severe pain syndrome, and leads to a reduction in the duration of hospital stay. These results of the laparoscopic technique are comparable with those of laparoscopic and open pelvic exenteration published by other authors.
The use and evaluation of prevention methods to reduce inflammatory and diffuse septic complications in patients undergoing pancreatic resection
Authors: Korobka V. L. , Korobka R. V. , Shapovalov A. M. 
Published: November 2018

Background:Surgery for chronic pancreatitis and pancreatic neoplasms is associated with a risk of acute destructive pancreatitis and pancreaticojejunal anastomotic leakage in the early postoperative period. Despite the availability of multiple surgical and pharmaceutical approaches to prevent these complications, they continue to be associated with high mortality.Aim:To evaluate the efficacy of the clinical use of our original preventive methods of postoperative pancreatitis and diffuse inflammatory and septic complications in patients undergoing pancreatic resection due to its benign and malignant diseases.Materials and methods: We retrospectively analyzed the results of surgical treatment of 524 patients following pancreatic resection. All patients underwent pancreatic surgery in the Rostov Regional Clinical Hospital (Rostov-on-Don, Russia) from February 2005 to April 2018 for the following indications: complicated chronic pancreatitis in 221 patient, pancreatic and major duodenal papilla tumors in 303 patients. Organ-preserving procedures were performed in 250 patients, and radical extended resections of the pancreas in 274 patients. In 489 patients, the procedures were finalized with the formation of anastomosis between the pancreatic duct and jejunum. In 373 patients, the reconstruction step included enterostomal drainage of the pancreatic duct. To prevent acute postoperative pancreatitis and diffuse septic and inflammatory complications, in 298 patients we used our original techniques, while 226 patients underwent conventional procedures.Results:Among 226 patients, who had underwent conventional procedures, the complications occurred in 75 (33.19%), with septic complications in 29.33% (22 patients). Of 298 patients, in whom any of the original prevention techniques had been used, the complications were seen in 67 (22.48%), with septic complications in 13.43% (9 patients). Seventeen (17, or 11.97% of the total number) patients had to be re-operated, with 15 (6.64%) having been initially operated without additional preventive measures, and 2 (0.67%) with the use of the original prevention techniques. Overall postoperative mortality was 2.48%. The causes of death were: peritonitis in 4 patients, arrosive bleeding from visceral arteries in 4, bleeding from pancreatic head stump into the omental sac in 2, bleeding at the pancreaticojejunal anastomosis in 1, and cardiac disorders in 2.Conclusion:The study results have shown that the use of techniques to prevent the spread of inflammation and septic in the abdominal cavity and decreasing the rates of postoperative necrotic pancreatitis in pancreatic resections allows for a reduction of these complications and related mortality.
Mindfulness-Based Stress Reduction for Newly Graduated Registered Nurses
Authors: Kulka Joanne M. , Chang De Gagne Jennie , Mullen Cydney K. , Robeano Karen 
Published: November 2018

Background The transition from student to professional nurse is an important milestone in the development of newly graduated nurses. Mindfulness-based stress reduction (MBSR) has been shown to reduce symptoms of stress in those engaged in regular practice (Bazarko, Cate, Azocar, & Kreitzer, 2013; Kabat-Zinn, 1990). Method The quality improvement project used a one-group pre-test/posttest design to measure newly graduated registered nurses’ awareness of mindfulness and perceived stress. Results Mindfulness awareness improved from pre-intervention ( M = 3.66, SD = .81) to post-innovation ( M = 4.03, SD = .69) although this was not statistically significant, ( t[67] = 1.93, p = .057). There was a statistically significant decrease in perceived stress from pre-innovation ( M = 19.47, SD = 7.16) to post-innovation (M = 15.71, SD = 6.90), ( t[66] = 2.16, p = .034). Qualitative themes of increased patient safety communication, and teamwork were identified. Conclusion MBSR has the potential to increase mindfulness and decrease perceived stress in newly graduated registered nurses, encouraging improved patient safety communication, and teamwork.
Community-Based Stroke Recognition Education and Response: An Evidence-Based Intervention Project
Authors: Sposito Jennifer , Zipf Amy , Alhowaymel Fahad , Tala Almutairi Mohammed , Breda Karen 
Published: November 2018

Background Stroke has a significant impact on mortality and disability in the United States. This led the aforementioned master's students to create a community-based educational intervention using stroke curriculum from the American Heart Association/American Stroke Association (AHA/ASA). Purpose The purpose of this evidence-based intervention project was to examine the effectiveness of public stroke education utilizing the AHA/ASAs Face, Arm, Speech, Time (FAST) curriculum for stroke symptom recognition and response (Jauch, et al., 2013) at three central Connecticut senior centers. Design This evidence-based intervention project was based on the theoretical framework of Dorothea Orem's Self-Care Deficit Theory (Petiprin, 2016). Nurses can provide stroke based education to older adults in the community, ultimately empowering participants to recognize and respond to stroke symptoms. Methods An educational session on the AHA/ASA FAST curriculum was presented by master's students to groups of senior adults at three different senior centers, followed by a post teach-back session conducted by the students in smaller groups to assess learning. The total number of participants was 62 ( n = 62). Results The majority of participants (87%) were able to accurately teach back the four components of the FAST curriculum after the educational intervention. Conclusions FAST was simple to teach and engaging for participants. Using the FAST curriculum in senior center populations increased the participants’ awareness of stroke signs and symptoms, and their willingness to activate the 911 emergency system. Implications for Practice Educational interventions in the community with older adults can produce increased awareness of stroke symptoms and willingness to respond when necessary.
The Global Burden of Musculoskeletal Pain—Where to From Here?
Authors: Blyth Fiona M. , Briggs Andrew M. , Schneider Carmen Huckel , Hoy Damian G. , March Lyn M. 
Published: November 2018

To summarize the current understanding of the global burden of musculoskeletal pain–related conditions, consider the process of evidence generation and the steps to generate global pain estimates, identify key gaps in our understanding, and propose an agenda to address these gaps, we performed a narrative review. In the 2010 Global Burden of Disease Study (GBD), which broadened the scope of musculoskeletal conditions that were included over previous rounds, low back pain imposed the highest disability burden of all specific conditions assessed, and subsequent GBD reports further reinforce the size of this burden. Over the past decade, the GBD has produced compelling evidence of the leading contribution of musculoskeletal pain conditions to the global burden of disability, but this has not translated into global health policy initiatives. However, system- and service-level responses to the disease burden persist across high-, middle-, and low-income settings. There is a mismatch between the burden of musculoskeletal pain conditions and appropriate health policy response and planning internationally that can be addressed with an integrated research and policy agenda.
A Healthy Retail Intervention in Native American Convenience Stores: The THRIVE Community-Based Participatory Research Study
Authors: Bird Jernigan Valarie Blue , Salvatore Alicia L. , Williams Mary , Wetherill Marianna , Taniguchi Tori , Jacob Tvli , Cannady Tamela , Grammar Mandy , Standridge Joy , Fox Jill , Tingle Owens JoAnna , Spiegel Jennifer , Love Charlotte , Teague Travis , Noonan Carolyn 
Published: November 2018

Objectives. To assess a healthy retail intervention in Tribal convenience stores in Oklahoma. Methods. We adapted healthy retail strategies to the context of 8 Tribally owned stores. We assessed individual- and store-level outcomes in a cluster-controlled intervention trial (April 2016–June 2017). We measured fruit and vegetable intake, store environment perceptions, and purchases before and after the intervention among a cohort of 1637 Native American shoppers. We used mixed-effects linear regression to estimate pre- to postintervention changes in and between groups. Results. We followed 74% of participants (n = 1204) 9 to 12 months. Intervention and control participants perceived healthier stores after intervention. Higher shopping frequency was related to purchases of fruits, vegetables, and healthy items. Conclusions. Intervention exposure was associated with healthy purchasing but not fruit and vegetable intake. Research is needed to further assess impacts of environmental interventions on intake. Public Health Implications. As the first healthy retail intervention in Tribally owned stores, our results contribute evidence for environmental and policy interventions to address obesity in Tribal Nations. Multicomponent interventions, led by Tribal leaders from diverse sectors, are needed to create healthy environments and sustainable improvements in Native American health.
Successful Implementation of New Technologies in Sour Oman Fields: Securing High Risk Wells, Savings & Production Increase
Authors: Narwal Tushar , Riyami Yaqoob , Rashdi Mansoor , Abri Zahir , Sariri Aisha , Benchekor Ahmed , Hadhrami Abdullah , Dsouza Rylan , Brodie Alan , Strom Kyle 
Published: November 2018

Abstract
In South Oman, PDO is producing from high Sour Fields (H2S 1-10%) with high reservoir pressures ranging from 50,000 to 100,000kpa for more than 20 yrs. Operating these high sour wells comes with huge challenges and risks, which can easily get escalated to very high levels in case of any integrity issues with the wells. These situations not only provide significant exposure to expensive and risky well interventions but also pose threats to production due to Simultaneous Operations (SIMOPS) issues.
The authors describe case studies where team was exposed to these challenging situations due to integrity failures in two such wells. New technologies were implemented which resulted in restoring the well integrity in a very cost effective manner (cost savings worth millions) and also reduced the HSE risks on the nearby operations. As a result, production was safeguarded (3-4% of Station Capacity) by allowing drilling of new wells and oil deferment from existing wells in the nearby area was avoided.
Intensive Tillage Converting Grassland to Cropland Immediately Reduces Soil Microbial Community Size and Organic Carbon
Authors: Cotton Jon , Acosta‐Martínez Veronica 
Published: November 2018

Core Ideas
Decreased CRP funding is resulting in US grassland being tilled.
Intensive tillage of grassland rapidly decreases soil health indicators.
One month after tilling grassland surface microbial biomass (0–10 cm) decreased 52%.
Soil organic C decreased by 20% in the top 30 cm after one growing season.
Alternative grassland conversion methods are needed to sustain soil health.
Intensive tillage of grassland has negative long‐term effects on soil health, but little data exist to understand how quickly this decline occurs. We sampled a commercial field in the semiarid Southern Plains of the United States before and after tilling grassland and compared the results to adjacent row crop and perennial grass fields. Within the first month of tillage, we detected losses of 52% of microbial biomass C (505 to 241 mg kg−1 soil), 33% of organic C (11.6 to 7.78 g kg−1 soil), 30% of total N (1.09 to 0.760 g kg−1 soil) and 64 to 70% of β‐glucosidase and phosphodiesterase activities. The rapid decreases in these soil health indicators demonstrate that tillage management decisions are crucial for maintaining soil health if perennial grasses are converted to row cropping.
Yield of Native Warm‐Season Grasses in Response to Nitrogen and Harvest Frequency
Authors: Rushing J. B. , Lemus R. W. , White J. A. , Lyles J. C. , Thornton M. T. 
Published: November 2018

Core Ideas
Within year, harvest frequency has the greatest effect on DM production of native warm‐season grasses.
Nitrogen has little effect on native warm‐season grass DM yield.
Eastern gamagrass can tolerate consecutive years of frequent defoliations and maintain yield.
Five native warm‐season grass species and mixtures were grown in east‐central Mississippi on a coarse‐loamy, siliceous, semiactive, thermic Glossic Fragiudult, to determine their potential as forage grasses in response to harvest frequency and N application. Established stands were harvested at 30, 40, 60, and 120 d intervals, and were fertilized with N rates of 0, 56, 112, 168, and 224 kg N ha−1 for two consecutive years (2016 and 2017). Dry matter (DM) yield and agronomic nitrogen use efficiency (aNUE) were analyzed. Year, treated as a repeated measure, was the main source of variation affecting DM yields. Within year, harvest frequency had the greatest effect on cumulative yields in 2016, accounting for 44% of the variation observed. This effect was not observed in 2017. Frequent defoliations led to overall lower yields in 2017. Nitrogen was significant, but moderately, accounting for 2 and 4% of variation for 2016 and 2017, respectively. Species was also significant for both years. Agronomic N use efficiency varied between year, species, N rate, and harvest frequency. Eastern gamagrass [Tripsacum dactyloides (L.) L.] was the only species in which cumulative DM yield remained consistent across both years of the study, regardless of harvest frequency or N application. Results suggest that rest periods should be based on species present, and that less frequent harvests are required for sustained DM yields.
Viscosity Is Linked to Temporal Behavior of Hydrocarbon Injury on a Bermudagrass Green
Authors: Berndt William , Riger Jonathan , Riger Charles 
Published: November 2018

Core Ideas
Temporal behavior of hydrocarbon injury varied with hydrocarbon fluid type.
Descriptors of injury behavior correlated with kinematic viscosity of hydrocarbon fluids.
Injury from high‐viscosity fluids began healing later and had longer recovery times.
Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review
Authors: Sharma Bhawana , Dabur Rajesh 
Published: November 2018

Background:Metabolic pathways perturbations lead to skeletal muscular atrophy in the cachexia and sarcopenia due to increased catabolism. Pro-inflammatory cytokines induce the catabolic pathways that impair the muscle integrity and function. Hence, this review primarily concentrates on the effects of pro-inflammatory cytokines in regulation of skeletal muscle metabolism.Objective:This review will discuss the role of pro-inflammatory cytokines in skeletal muscles during muscle wasting conditions. Moreover, the coordination among the pro-inflammatory cytokines and their regulated molecular signaling pathways which increase the protein degradation will be discussed.Results:During normal conditions, pro-inflammatory cytokines are required to balance anabolism and catabolism and to maintain normal myogenesis process. However, during muscle wasting their enhanced expression leads to marked destructive metabolism in the skeletal muscles. Proinflammatory cytokines primarily exert their effects by increasing the expression of calpains and E3 ligases as well as of Nf-κB, required for protein breakdown and local inflammation. Proinflammatory cytokines also locally suppress the IGF-1and insulin functions, hence increase the FoxO activation and decrease the Akt function, the central point of carbohydrates lipid and protein metabolism.Conclusion:Current advancements have revealed that the muscle mass loss during skeletal muscular atrophy is multifactorial. Despite great efforts, not even a single FDA approved drug is available in the market. It indicates the well-organized coordination among the pro-inflammatory cytokines that need to be further understood and explored.
Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management
Authors: Leung Alexander K. C. , Lam Joseph M. , Leong Kin Fon 
Published: November 2018

Background:
The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based
on lesion morphology, the presence of a positive Darier sign, and the absence of systemic involvement.
Knowledge of this condition is important so that an accurate diagnosis can be made.

Objective:
To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and
management of a solitary cutaneous mastocytoma.

Methods:
A PubMed search was completed in Clinical Queries using the key term "solitary cutaneous
mastocytoma". The search strategy included meta-analyses, randomized controlled trials,
clinical trials, observational studies, and reviews. Only papers published in English language were
included. The information retrieved from the above search was used in the compilation of the present
article.

Results:
Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow-
brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in
diameter. The lesion often has a peau d'orange appearance and a leathery or rubbery consistency. A
solitary cutaneous mastocytoma may urticate spontaneously or when stroked or rubbed (Darier
sign). Organomegaly and lymphadenopathy are characteristically absent. The majority of patients
with skin lesions that erupt within the first two years of life have spontaneous resolution of the lesions
before puberty. Treatment is mainly symptomatic. Reassurance and avoidance of triggering
factors suffice in most cases.

Conclusion:
The diagnosis is mainly clinical, based on the morphology of the lesion, the presence
of a positive Darier sign, and the absence of systemic involvement. A skin biopsy is usually not
necessary unless the diagnosis is in doubt.
Simultaneous Determination of Three Alkaloids in Wutou Decoction in Rat Plasma Via the UPLC–MS/MS Method and its Application in Pharmacokinetic Study
Authors: Jian WU , Yu-bin JI , Ying-jie Liu , Ying XU , Wei Zheng , Miao Yu 
Published: November 2018

Introduction:
Wutou decoction has been wildly applied for the treatment of RA in China for
several thousand years.

Methods:
This study aims to develop a highly sensitive and specific ultra performance liquid chromatography
coupled with tandem mass spectrometry and electrospray ionization (UPLC-ESI-MS/MS)
method to explore the pharmacokinetic properties of three representative bioactive alkaloids after intragastric
administration of Wutou decoction in rats. Chromatographic separation was performed on a C18
column under the Multiple Reaction Monitoring (MRM) in the positive electrospray ionization (ESI)
mode. The pharmacokinetic parameters were evaluated by software DAS 3. 0.

Results:
The validation of the method was achieved in accordance with the FDA guidelines. The results
of pharmacokinetic study showed that the in vivo concentrations of benzoylmesaconine and
benzoylhypaconine were significantly higher than benzoylaconine. Our PK results showed that these
three compounds were quickly absorbed after the administration of Wutou decoction, and Tmax ranged
from 30 min to 45 min.

Conclusion:
The results of pharmacokinetic study showed that the in vivo concentrations of
benzoylmesaconine and benzoylhypaconine were significantly higher than benzoylaconine. There were
also similar pharmacokinetic behaviors observed among BAC, BHA, and BMA after oral administration
of WTD.
Cytotoxic Action of N-aryl, Furan-derived Aminophosphonates against HT29 and HCT116 Cancer Cell Lines
Authors: Lewkowski Jarosław , Rzeszotarska Edyta , Matusiak Agnieszka , Morawska Marta , Gajek Gabriela , Nowak Karolina , Kontek Renata 
Published: November 2018

Background:
The anticancer activity of aminophosphonic derivatives has been described extensively, some
recent papers included furan-derived aminophosphonates and their cytostatic action against various cancer cells.

Objective:
A series of twelve furan-derived dibenzyl and diphenyl aminophosphonates 2a-f and 3a-f was synthesized
and tested in aspect of their cytotoxic action on two cell lines of colorectal cancer: HT29 and HCT116.
Seven of them are new compounds, while the rest five have already been published by us, together with their
cytotoxic action against squamous esophageal cancer cells.

Methods:
To estimate the cytotoxicity effect of tested compounds MTT test was used. Pro-apoptotic activity of
five selected compounds was evaluated using APC Annexin V Apoptosis Detection Kit on a flow cytometer.
Quantification of caspases 3/7 activity was performed using Caspase-Glo® 3/7 Assay Kit.

Results:
Five of these aminophosphonates showed significant cytotoxicity higher than those of cisplatin. Simultaneous
evaluation of their cytotoxicity against PBLs revealed that these compounds are rather not harmful for
regular human lymphocytes. Tests on apoptosis vs. their necrotic actions on cells were performed with selected
compounds showing the most significant cytotoxicity against cancer cells and all tested compounds did not
induce significant increase of necrosis in cells, whereas they showed moderate-to-strong proapoptotic actions
even at the lowest applied concentration. Caspase 3/7 activity results confirmed proapoptotic properties of tested
aminophosphonates.

Conclusion:
From among studied compounds, dibenzyl N-phenyl substituted amino(2-furyl)methylphsophonates
were found to be more potent compounds in aspect of their antiproliferative action than the corresponding
diphenyl derivatives.