bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report on the APMP.M.F-S3 supplementary comparison for 1 kN force
Authors: Hayashi T , Ueda K , Maejima H , Hafid  , Nurcahyono D 
Published: January 2019

The comparison results revealed the equivalence of forces realized by the 1 kN and 20 kN DWMs of RCM-LIPI (Indonesia) to those by the 3 kN DWM of NMIJ (Japan) within their claimed uncertainties.
KEY WORDS FOR SEARCH
Force, Equivalence, RCM-LIPI, NMIJ, Supplementary comparison

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
AQUAPONY: visualization and interpretation of phylogeographic information on phylogenetic trees
Authors: Cazaux Bastien , Castel Guillaume , Rivals Eric 
Published: January 2019

Abstract

Motivation
The visualization and interpretation of evolutionary spatiotemporal scenarios is broadly and increasingly used in infectious disease research, ecology or agronomy. Using probabilistic frameworks, well-known tools can infer from molecular data ancestral traits for internal nodes in a phylogeny, and numerous phylogenetic rendering tools can display such evolutionary trees. However, visualizing such ancestral information and its uncertainty on the tree remains tedious. For instance, ancestral nodes can be associated to several geographical annotations with close probabilities and thus, several migration or transmission scenarios exist.

Results
We expose a web-based tool, named AQUAPONY, that facilitates such operations. Given an evolutionary tree with ancestral (e.g. geographical) annotations, the user can easily control the display of ancestral information on the entire tree or a subtree, and can view alternative phylogeographic scenarios along a branch according to a chosen uncertainty threshold. AQUAPONY interactively visualizes the tree and eases the objective interpretation of evolutionary scenarios. AQUAPONY’s implementation makes it highly responsive to user interaction, and instantaneously updates the tree visualizations even for large trees (which can be exported as image files).

Availability and implementation
AQUAPONY is coded in JavaScript/HTML, available under Cecill license, and can be freely used at http://www.atgc-montpellier.fr/aquapony/.
A network of networks approach for modeling interconnected brain tissue-specific networks
Authors: Kawakubo Hideko , Matsui Yusuke , Kushima Itaru , Ozaki Norio , Shimamura Teppei 
Published: January 2019

AbstractMotivationRecent sequence-based analyses have identified a lot of gene variants that may contribute to neurogenetic disorders such as autism spectrum disorder and schizophrenia. Several state-of-the-art network-based analyses have been proposed for mechanical understanding of genetic variants in neurogenetic disorders. However, these methods were mainly designed for modeling and analyzing single networks that do not interact with or depend on other networks, and thus cannot capture the properties between interdependent systems in brain-specific tissues, circuits and regions which are connected each other and affect behavior and cognitive processes.ResultsWe introduce a novel and efficient framework, called a ‘Network of Networks’ approach, to infer the interconnectivity structure between multiple networks where the response and the predictor variables are topological information matrices of given networks. We also propose Graph-Oriented SParsE Learning, a new sparse structural learning algorithm for network data to identify a subset of the topological information matrices of the predictors related to the response. We demonstrate on simulated data that propose Graph-Oriented SParsE Learning outperforms existing kernel-based algorithms in terms of F-measure. On real data from human brain region-specific functional networks associated with the autism risk genes, we show that the ‘Network of Networks’ model provides insights on the autism-associated interconnectivity structure between functional interaction networks and a comprehensive understanding of the genetic basis of autism across diverse regions of the brain.Availability and implementationOur software is available from https://github.com/infinite-point/GOSPEL.Supplementary informationSupplementary data are available at Bioinformatics online.
Plasticity in the antipredator behavior of the orange-footed sea cucumber under shifting hydrodynamic forces
Authors: Brown Nicholas A W , Wilson David R , Gagnon Patrick 
Published: January 2019

AbstractMarine invertebrates that move too slowly to evade unfavorable environmental change may instead exhibit phenotypic plasticity, allowing them to adjust to varying conditions. The orange-footed sea cucumber Cucumaria frondosa is a slow-moving suspension feeder that is preyed on by the purple sunstar Solaster endeca. The sea cucumber’s antipredator behavior involves changing shape and detaching from the substratum, which might increase its probability of being displaced by water motion into an unsuitable environment. We hypothesized that sea cucumbers’ antipredator responses would be diminished under stronger hydrodynamic forces, and that behavioral strategies would be flexible so that individuals could adjust to frequent changes in water flows. In a natural orange-footed sea cucumber habitat, individuals lived along a pronounced hydrodynamic gradient, allowing us to measure antipredator behavior under different water flow strengths. We placed purple sunstars in physical contact with sea cucumbers living at various points along the gradient to elicit antipredator responses. We then repeated this procedure in a laboratory mesocosm that generated weak and strong hydrodynamic forces similar to those observed at the field site. Subjects in the mesocosm experiment were tested in both wave conditions to determine if their antipredator behavior would change in response to sudden environmental change, as would be experienced under deteriorating sea conditions. Antipredator responses did not covary with hydrodynamic forces in the field. However, antipredator responses in the mesocosm experiment increased when individuals were transplanted from strong to weak forces and decreased when transplanted from weak to strong forces. Overall, our results indicate environmentally induced plasticity in the antipredator behavior of the orange-footed sea cucumber.
Aortic root enlargement to mitigate patient–prosthesis mismatch: do early adverse events justify reluctance?†
Authors: Haunschild Josephina , Scharnowski Sven , Mende Meinhard , von Aspern Konstantin , Misfeld Martin , Mohr Friedrich-Wilhelm , Borger Michael A , Etz Christian D 
Published: January 2019

Abstract

OBJECTIVES
Concomitant aortic root enlargement (ARE) at the time of surgical aortic valve replacement can be performed to avoid patient–prosthesis mismatch, an important predictor of adverse long-term outcome.

METHODS
We performed a single-centre, retrospective analysis of 4120 patients receiving isolated aortic valve replacement, of whom 171 (4%) had concomitant ARE between January 2005 and December 2015. The analysis of postoperative outcome and early mortality was performed. Owing to inequality of the groups, patients were matched 1:1.

RESULTS
The mean age of all 4120 patients was 68.8 ± 10.5 years, and comorbidities were equally balanced after matching. The mean aortic cross-clamp time, cardiopulmonary bypass time and total operative time were prolonged by 19, 20 and 27 min in the ARE group, respectively. Early mortality was not statistically significantly different with 1.4% in the surgical aortic valve replacement and 1.8% in the ARE group. Postoperative complications were <5% in all matched 338 patients: bleeding (3% vs 3%), pericardial effusion (3.0% vs 4.2%), sternal instability (1.8% vs 0%) and sternal wound infection (3.0% vs 1.2%). A significant higher number of patients had respiratory failure after ARE (unmatched: 17.1% vs 9.9%, P < 0.001; matched: 18.3% vs 9.5%, P = 0.028). Factors independently associated with overall mortality were age [hazard ratio (HR) 1.71], chronic obstructive pulmonary disease (HR 1.47), diabetes (HR 1.82), atrial fibrillation (HR 2.14) and postoperative respiratory failure (HR 2.84).

CONCLUSIONS
ARE can be performed safely in experienced centres with no significant increase in the risk of early postoperative surgical complications and early mortality. However, the surgeon and the intensive care unit team should be aware of an increased risk for postoperative respiratory failure in ARE patients.
Mental health first aid for the UK Armed Forces
Authors: Crone Diane M , Sarkar Mustafa , Curran Thomas , Baker Colin M , Hill Denise , Loughren Elizabeth A , Dickson Tabitha , Parker Andrew 
Published: January 2019

Abstract
Education programmes in mental health literacy can address stigma and misunderstanding of mental health. This study investigated self-rated differences in knowledge, attitudes and confidence around mental health issues following participation in a bespoke Mental Health First Aid (MHFA) training course for the Armed Forces. The mixed methods approach comprised quantitative surveys and qualitative interviews. A survey, administered immediately post-training (n = 602) and again at 10-months post-attendance (n = 120), asked participants to rate their knowledge, attitudes and confidence around mental health issues pre- and post-training. Quantitative findings revealed a significant increase in knowledge, positive attitudes and confidence from the post-training survey which was sustained at 10-months follow-up.Semi-structured telephone interviews (n = 13) were conducted at follow-up, 6-months post-attendance. Qualitative findings revealed that participation facilitated an ‘ambassador’ type role for participants. This study is the first to have investigated the effect of MHFA in an Armed Forces community. Findings show participants perceived the training to increase knowledge regarding mental health and to enhance confidence and aptitude for identifying and supporting people with mental health problems. Results suggest that such an intervention can provide support for personnel, veterans and their families, regarding mental health in Armed Forces communities.
Leaving the Victorian Children’s Institution: Aftercare, Friendship and Support
Authors: Soares Claudia 
Published: January 2019

Abstract
This article explores the needs of young people leaving residential care and the provision of aftercare support in the late-nineteenth and early-twentieth centuries. Young people’s discharge, aftercare and post-institutional experiences occupy a peripheral position in scholarship on institutional care. This essay broadens interpretations of aftercare, which have been presented as inadequate inspections that monitored employment performance. Examining the formal and informal systems that aimed to enhance care-leavers’ welfare and wellbeing, the essay offers new understandings of the ongoing provision of practical and emotional support to young people, and the importance of sustained contact and affective ties between former inmates and institutional staff.
The Batalin–Vilkovisky Structure on the Tate–Hochschild Cohomology Ring of a Group Algebra
Authors: Liu Yuming , Wang Zhengfang , Zhou Guodong 
Published: January 2019

AbstractWe determine the Batalin–Vilkovisky structure on the Tate–Hochschild cohomology of the group algebra $kG$ of a finite group $G$ in terms of the additive decomposition. In particular, we show that the Tate cohomology of $G$ is a Batalin–Vilkovisky subalgebra of the Tate–Hochschild cohomology of the group algebra $kG$ and that the Tate cochain complex of $G$ is a cyclic ${A_{\infty}}$-subalgebra of the Tate–Hochschild cochain complex of $kG$.
Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients
Authors: Lempers Vincent J , Meuwese Edmé , Mavinkurve-Groothuis Annelies M , Henriet Stefanie , van der Sluis Inge M , Hanff Lidwien M , Warris Adilia , Koch Birgit C P , Brüggemann Roger J 
Published: January 2019

AbstractVoriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations result in target attainment. Patients <19 years from two pediatric hematologic-oncology wards were retrospectively identified based on unexplained high voriconazole trough concentrations (Cmin > 6 mg/l). Patient demographics, clinical characteristics, treatment, voriconazole dosing information, voriconazole Cmin before and after adjustment based on TDM were obtained. Twenty-one patients, median (range) age 7.0 (1.2–18.5) years, were identified in two centers. First Cmin (3.1 mg/l [0.1–13.5]) was obtained after 3 days (1–27) of treatment. The median of all Cmin (n = 485, median 11 per patient) was 2.16 mg/l (0.0 (undetectable)–28.0), with 24.1% of Cmin < 1 mg/l, 48.9% 1–4 mg/l, 9.3% 4–6 mg/l, and 17.7% > 6 mg/l. Intrapatient variability was large (94.1% for IV, 88.5% for PO). Dose increases at Cmin < 1 mg/l resulted in an increased Cmin in 76.4%, with 60% between 1 and 4 mg/l. Dose decreases at Cmin > 6 mg/l resulted in a decreased Cmin in 80%, with 51% between 1 and 4 mg/l. Overall, in 45% of the cases (33 out of 55 and 12 out of 45) therapeutic targets were attained after dose adjustment. Fifty-five percent of initial Cmin was outside the therapeutic target of 1–4 mg/l, with multiple dose adaptations required to achieve therapeutic concentrations. Only 60% and 51% of dose adaptations following sub- and supra-therapeutic Cmin, respectively, did result in target attainment. Intensive and continuous TDM of voriconazole is a prerequisite for ensuring adequate exposure in pediatric patients.
Female lower urinary tract microbiota do not correspond to IC/PBS symptoms: a case-controlled study
Authors: Bresler L. , Price T.K. , Tulke M. , Hilt E.E. , Joyce C. , Fitzgerald C.M. , Wolfe A.J. 
Published: January 2019

ABSTRACTOBJECTIVECurrent etiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is poorly understood and multifactorial. Recent studies suggest the female urinary microbiota (FUM) contribute to IC/PBS symptoms. This study was designed to determine if the FUM, analyzed using mid-stream voided urine samples, differs between IC/PBS patients and controls.MATERIALS AND METHODSThis prospective case-controlled study compared the voided FUM of women with symptoms of urinary frequency, urgency, and bladder pain for greater than 6 months to the voided FUM of healthy female controls without pain. Bacterial identification was performed using 16S rRNA gene sequencing and EQUC, a validated enhanced urine culture approach. Urotype was defined by a genus present at >50% relative abundance. If no genus was present above this threshold, the urotype was classified as ‘mixe’. Chi-square and Fisher’s exact tests were performed. P-values <0.05 were considered significant.RESULTSA mid-stream voided specimen was collected from 21 IC/PBS patients and 20 asymptomatic controls. Both groups had similar demographics. Urotypes did not differ between cohorts as assessed by either EQUC or 16S rRNA gene sequencing. We detected no significant differences between cohorts in terms of alpha-diversity. Cohorts also were not distinct using Principle Component Analysis or hierarchical clustering. Detection by EQUC of bacterial species considered uropathogenic was high in both cohorts, but detection of these uropathogenic species did not differ between groups (p=0.10).CONCLUSIONSEnhanced culture and modern DNA sequencing methods provide evidence that IC/PBS symptoms may not be related to differences in the FUM, at least not its bacterial components. Future larger studies are needed to confirm this preliminary finding.
Epidemic foci of hemorrhagic fever with renal syndrome in Shandong Province, China, based on patients, rodents and molecular epidemiology characteristics, 2012-2015
Authors: Zheng Zhaolei , Wang Peizhu , Wang Zhiqiang , Zhang Dandan , Wang Xu , Zuo Shuqing , Li Xiujun 
Published: January 2019

AbstractBackgroundHemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by hantaviruses, is endemic in China and remains a serious public health problem. Historically, Shandong Province has had the largest HFRS burden in China. However, we do not have a comprehensive and clear understanding of the current epidemic foci of HFRS in Shandong Province.Methodology/Principal FindingsThe incidence and mortality rates were calculated, and a phylogenetic analysis was performed after laboratory testing of the virus in rodents. Spatial epidemiology analysis was applied to investigate the epidemic foci, including their sources. A total of 6,206 HFRS cases and 59 related deaths were reported in Shandong Province. The virus carriage rates of the rodents Rattus norvegicus, Apodemus agrarius and Mus musculus were 10.24%, 6.31% and 0.27%, respectively. The phylogenetic analysis indicated that two novel viruses isolated from R. norvegicus in Anqiu City and Qingzhou City were dissimilar to the other isolated strains, but closely related to strains previously isolated in northeastern China. Three epidemic foci were defined, two of which were derived from the Jining and Linyi epidemic foci, respectively, while the other was the residue of the Jining epidemic focus.Conclusions/SignificanceThe southeastern and central Shandong Province are current key HFRS epidemic foci dominated by A. agrarius and R. norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS.Author summaryHemorrhagic fever with renal syndrome (HFRS) is a global infectious disease, which is still a serious public health threat in China today. The reported HFRS cases in Shandong Province accounted for approximate one third of total cases in the whole country. HFRS is a zoonosis mainly caused by Hantaan virus (HTNV) and Seoul virus (SEOV), which natural rodent hosts are A. agrarius and R. norvegicus, respectively. To explore the current HFRS epidemic foci based on patients, rodents and molecular epidemiology characteristics in Shandong Province, we collected the records of HFRS cases from whole province and the rodents captured in 14 surveillance sites. We found that the epidemic situation of HFRS is quiet different in temporal and spatial distribution. Three epidemic foci were defined based on patients, rodents and molecular epidemiology characteristics. The situation of HFRS epidemic foci in Shandong Province was clear. Our study provides a reference for relevant departments to develop key prevention strategies.
A therapeutic approach to learning through creative storytelling
Authors: Rutherford Jessica I. 
Published: January 2019

PurposeThe purpose of this paper is to provide an overview of a Learning Programme designed around the animation film-making process, contextualising abstract concepts to address the cognitive limitations of children with foetal alcohol spectrum disorders (FASD).Design/methodology/approachAnimation production is tactile, multimodal and multisensory which allows for wide application alongside traditional learning tools, targeting multiple learning pathways with its visual, auditory and kinaesthetic approach. Individuals with FASD require information to be explained in a concrete way to enable them to process and understand. Most information can be drawn, providing a visual to assist the individual, but we must also consider abstract concepts which require further explanation or a series of drawings to display the concepts development. Animation, however, allows us the opportunity to make abstract concepts concrete, contextualising the concept in a visualisation of the child’s story, narrated with their voice and designed to represent their world, in a film produced entirely by them, therefore allowing opportunity for a therapeutic approach to learning through storytelling. This learning tool is designed to be implemented in a specifically designed therapeutic learning environment to enhance the benefits of participation from both educational and therapeutic perspectives.FindingsA review of relevant literature highlights a significant connection between animation, the learning needs of those with FASD and the need for a therapeutic learning environment. This is a proof of concept study, demonstrating the value and potential of animation film making in this new area of practical application. The study closely considers the learning environment from a therapeutic perspective and aims not only to develop a learning tool but to also define the optimum therapeutic learning environment. The study is therefore untested at this stage.Practical implicationsPhase 2 of this ongoing research study seeks to explore additional benefits of participation and engagement with the process in an educational and therapeutic context. Considerations of the therapeutic learning environment will be further explored to determine the optimum setting to support the ongoing learning of this pedagogically bereft (Carpenter, 2011) population. Phase 2 also aims to clarify therapeutic benefits as additional outcomes of participation in this programme.Originality/valueThe proposed learning tool and therapeutic learning environment outlined in this paper is an original contribution to knowledge and if found to be successful, could offer significant opportunities for a therapeutic approach to education for this population and others.
E-books: yes or no? A case study of undergraduate students at the University of Namibia
Authors: Leonard Anna , Snyman Maritha 
Published: January 2019

Purpose
The purpose of the paper is to determine how undergraduate students at the University of Namibia perceive and use e-books. This paper aims to report on the result of a study that investigated the adoption of, views about and use of e-books at the University of Namibia.

Design/methodology/approach
The study used a mixed-method approach. It used three methods, namely, focus group interviews, observation combined with the think aloud and a survey to investigate how undergraduate students use e-books.

Findings
Major findings of the study indicated that students use and prefer e-books for course and research purposes. But they mainly use non-library search engines such as Google, Yahoo and commercial sites. Lack of searching skills, slow/unreliable internet and limited or lack of relevant content of e-book collections were the major hindrances affecting e-book use.

Originality/value
The findings of the study could be used to understand the use of e-books at the University of Namibia and at academic institutions with similar context to Namibia. The study contributes to the knowledge base of library and information science (LIS) by providing a detailed analysis on the views and use of e-books at the University of Namibia. The recommendations of this study can be adopted by libraries in other countries with similar socio-economic conditions like Namibia.