bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le bien-être numérique, un enjeu de santé mentale technologique : la place du téléphone intelligent
Authors: Khazaal Yasser , Vera Cruz Germano 
Published: November 2024

Objectifs Présenter le concept de bien-être numérique et explorer la place d’outils digitaux au service de ce bien-être.
Méthode L’article se base sur une description du concept de bien-être numérique, des modèles d’intervention actuellement disponibles et des possibilités d’évolution de ces modèles.
Résultats L’utilisation des téléphones intelligents ou « smartphones » est devenue omniprésente dans la société moderne, en particulier chez les adolescents et les jeunes adultes. Avec une connectivité intelligente, interactive, pratique et permanente, les individus sont confrontés à de nouveaux défis et à de nouvelles pressions liées au moment, à l’endroit, à la manière et à l’intensité avec lesquels ils décident de se connecter ou de se déconnecter des services fournis par le téléphone intelligent. L’utilisation problématique des téléphones intelligents a été associée à des troubles de la santé mentale et à des problèmes fonctionnels. Face à cet enjeu d’un usage du numérique au service du bien-être, le concept de bien-être numérique a récemment été introduit. Il s’agit de l’expérience subjective et individuelle d’un équilibre optimal entre les avantages et les inconvénients associés à la technologie numérique. Des outils technologiques orientés sur le contrôle des temps d’usage des écrans sont proposés. Les résultats de ces approches sont mitigés.
Conclusion Pour une efficacité optimale, une meilleure intégration des interfaces dynamiques entre l’humain et la machine pourrait être essentielle.
Développer le flair du psychiatre : des enseignements tirés de deux cas cliniques de syndrome de référence olfactive
Authors: Masse Morganne , Stip Emmanuel 
Published: November 2024

L’olfaction est souvent négligée en sémiologie psychiatrique, malgré sa pertinence clinique et son impact sur le fonctionnement social. Le syndrome de référence olfactive (SRO), qui se manifeste par une fausse croyance selon laquelle une personne émet une odeur nauséabonde, entraîne une détresse sévère et altère le fonctionnement social. Cet article cherche à souligner la pertinence de l’olfaction dans la sémiologie psychiatrique, en mettant l’accent sur le SRO. Nous présentons une étude de deux hommes atteints de SRO, suivis en unité de troubles psychotiques, selon les critères CARE. Une revue de littérature effectuée selon les critères PRISMA, examine 53 études issues de PubMed, PsychInfo, Google Scholar et Cairns et complète les présentations cliniques.
Cette analyse permet ainsi une discussion sur les connaissances actuelles du SRO, en réfutant, nuançant et validant les hypothèses en vigueur sur la nosographie et l’étiologie du trouble. Nous proposons d’approfondir le rôle de l’olfaction, en explorant son association avec les émotions, la formation des impressions et la Théorie de l’Esprit. Affiner notre compréhension de l’influence de l’olfaction sur le fonctionnement psychique et social pourra enrichir nos approches diagnostiques et thérapeutiques en psychiatrie du SRO.
Un regard sur le domaine de la psychothérapie et sur le développement du programme APAP
Authors: Borgeat François , Amado Danielle , Lallier Carmen , Barabé Joanie 
Published: November 2024

Objectif Le domaine des psychothérapies est en demande accrue et ses offres s’avèrent très diversifiées. L’objectif du présent article est d’effectuer un survol basé sur des recherches cliniques et sur des résultats de psychothérapeutes avec des formes de psychothérapies établies et pratiquées dans des milieux universitaires et plus récemment à l’Institut universitaire en santé mentale de Montréal.
Méthode Les méthodes de recherche et d’évaluations cliniques ont changé au cours de plusieurs années. Les psychothérapeutes ont varié leurs approches selon les milieux et plusieurs ont participé à de nombreuses recherches et publications. Les recherches au fil des années sont discutées ce qui inclut le développement de stratégies récentes dont le programme informatisé APAP ainsi appelé pour Augmentation de la Psychothérapie par Amorçage Préconscient. Cette méthode vise à faciliter le changement cognitif et propose une stratégie d’écoute préconsciente répétitive.
Résultats Les recherches s’étendent sur plusieurs années, car les psychothérapeutes étaient aussi des cliniciens et leurs contributions variaient. Par exemple, certains premiers travaux avec des patients volontaires montraient l’intérêt des écoutes préconscientes répétitives. Puis, par la suite, dans le contexte de l’IUSMM, une recherche à double insu a été réalisée et a montré l’efficacité de ce nous avons appelé l’amorçage préconscient pour faciliter le changement cognitif.
Conclusion La recherche sur la psychothérapie demeure difficile et s’étale sur de longues périodes, par exemple la recherche mentionnée plus haut s’est étendue sur plus d’une année. Les recherches à double insu s’avèrent peu nombreuses, car les placebos crédibles sont rares. Notre recherche était favorisée par l’écoute préconsciente échappant à la conscience, et il nous était possible de comparer les effets de stimuli porteurs de messages préconscients visant les besoins des patients à divers contenus variés ou neutres, par exemple des nombres aléatoires.
Study of Nitrogen Use Efficiency in Potato (Solanum tuberosum L.)
Authors: Sandilya Vivek Kumar , Rangare N. R. , Khokhar Dharmendra , Kumar Vikky , Rangare Smita Bala 
Published: November 2024

The study was conducted under All India Coordinated Research project on potato at Research cum Instructional farm, Department of Genetics and Plant Breeding, College of Agriculture, Indira Gandhi Krishi Vishwavidyalaya, Raipur, (C.G.) during Rabi season 2021-22, in split plot design with three replications, for this research the experimental material consisting of twenty potato genotypes including two check variety Kufri Khyati and Kufri Chipsona-1.With three Nitrogen levels (0, 180 and 250 kg N/ ha), to find out the N requirement and Nitrogen use efficiency of Potato genotypes. The results of the present experiment revealed that all the genotypes are showing genotypic variability for NUE, there is sufficient variation for NUE. The genotypes used in the experiment show response to nitrogen and performing different the same genotype in three different nitrogen levels, among the twenty genotypes P-73 recorded maximum Nitrogen Use efficiency at all the levels of nitrogen followed by Kufri Mohan and Kufri Lalima. Genotype P-73 proved to possess high tolerance to N stress and was the most nitrogen-efficient variety followed by Kufri Mohan and Kufri Neelkanth. This experiment can be concluded that, the variety responded the same at 180 and 250 Kg Nitrogen can be recommended to apply only 180 kg of Nitrogen, the knowledge of NUE can save the money and land of farmers by minimal use of Nitrogen.
Improvements in treatment planning calculations motivated by tightening IMRT QA tolerances
Authors: Stambaugh Cassandra , Gagneur Justin , Uejo Arielle , Clouser Edward , Ezzell Gary 
Published: January 2019

AbstractImplementing tighter intensity modulated radiation therapy (IMRT) quality assurance (QA) tolerances initially resulted in high numbers of marginal or failing QA results and motivated a number of improvements to our calculational processes. This work details those improvements and their effect on results. One hundred eighty IMRT plans analyzed previously were collected and new gamma criteria were applied and compared to the original results. The results were used to obtain an estimate for the number of plans that would require additional dose volume histogram (DVH)‐based analysis and therefore predicted workload increase. For 2 months and 133 plans, the established criteria were continued while the new criteria were applied and tracked in parallel. Because the number of marginal or failing plans far exceeded the predicted levels, a number of calculational elements were investigated: IMRT modeling parameters, calculation grid size, and couch top modeling. After improvements to these elements, the new criteria were clinically implemented and the frequency of passing, questionable, and failing plans measured for the subsequent 15 months and 674 plans. The retrospective analysis of selected IMRT QA results demonstrated that 75% of plans should pass, while 19% of IMRT QA plans would need DVH‐based analysis and an additional 6% would fail. However, after applying the tighter criteria for 2 months, the distribution of plans was significantly different from prediction with questionable or failing plans reaching 47%. After investigating and improving several elements of the IMRT calculation processes, the frequency of questionable plans was reduced to 11% and that of failing plans to less than 1%. Tighter IMRT QA tolerances revealed the need to improve several elements of our plan calculations. As a consequence, the accuracy of our plans have improved, and the frequency of finding marginal or failing IMRT QA results, remains within our practical ability to respond.
LncRNA MAFG‐AS1 facilitates the migration and invasion of NSCLC cell via sponging miR‐339‐5p from MMP15
Authors: Jia You Chao , Wang Jian Yi , Liu Yu Ying , Li Bin , Guo Hui , Zang Ai Min 
Published: January 2019

AbstractNon‐small‐cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG‐AS1) was over‐expressed in NSCLC tissues and cell lines. Overexpression of MAFG‐AS1 promoted the migration, invasion and enhanced epithelial‐mesenchymal transition (EMT) of NSCLC cell. In addition, miR‐339‐5p was predicted to be a target of MAFG‐AS1 and the level of miR‐339‐5p was down‐regulated in NSCLC. Over‐expression of MAFG‐AS1 significantly decreased the level of miR‐339‐5p in NSCLC cell. Moreover, the matrix metalloproteinase 15 (MMP15) was identified to be a target of miR‐339‐5p. The level of MMP15 was negatively regulated by miR‐339‐5p whereas positively controlled by MAFG‐AS1. In addition, up‐regulation of miR‐339‐5p neutralized the promoting impact of MAFG‐AS1 on the migration, invasion and EMT of NSCLC cell. Finally, the xenograft model suggested that MAFG‐AS1 promoted the metastasis of NSCLC cell in vivo. Altogether, we proved that MAFG‐AS1‐miR‐339‐5p‐MMP15 axis might be a promising therapeutic target for the treatment of patients with NSCLC.
Catalan Virgin Olive Oil Protected Designations of Origin: Physicochemical and Major Sensory Attributes
Authors: Vichi Stefania , Tres Alba , Quintanilla‐Casas Beatriz , Bustamante Julen , Guardiola Francesc , Martí Esteve , Hermoso Juan F. , Ninot Antonia , Romero Agustí 
Published: January 2019

Catalonia, located in the northeast of Spain, comprises five extra virgin olive oil (EVOO) protected designations of origin (PDOs). Despite the proximity between them, these PDOs represent unique pedoclimatic conditions and traditional olive cultivars that are briefly reviewed in the present manuscript. In addition to the compliance with quality standards fixed by product specifications, EVOOs show singular and distinctive composition and sensory profiles. With the aim to describe the characteristics of Catalan EVOOs, their sensory and analytical traits are reviewed with the support of data collected between 2009 and 2017 in more than 42 milling facilities from the five Catalan PDOs, within the frame of official surveys launched by the Catalan Government.Practical Applications: A detailed knowledge of the characteristics of differentiated‐quality productions will favor their valorization and protection, improving their image and increasing the consumer confidence. For this reason, studies to objectively define the characteristics of PDO EVOOs are useful tools to promote this sector.Despite the proximity between Catalan PDOs, their unique pedoclimatic conditions and traditional olive cultivars contribute to produce extra virgin olive oils with singular and distinctive composition and sensory profiles.
Recent Amendment to Product Specification of Brisighella PDO (Emilia‐Romagna, Italy): Focus on Phenolic Compounds and Sensory Aspects
Authors: Barbieri Sara , Bendini Alessandra , Gallina Toschi Tullia 
Published: January 2019

The Brisighella Protected Designation of Origin (PDO) extra virgin olive oil (EVOO) has been protected by European trademark since 1996. It is obtained from olives belonging to the cv “Nostrana di Brisighella” (must make up at least 90% of groves) grown exclusively in Brisighella, a circumscribed area of the Emilia‐Romagna region, in the north of Italy. Brisighella PDO EVOO is produced by the unique plant mill of the Consortium (Consorzio Olio DOP “Brisighella”). In this research, minor amendments to product specification of Brisighella PDO approved by the EU in 2016 are described. The proposed modifications to the Brisighella PDO product specification are supported by chemical‐sensory analyses carried out on 15 EVOOs from cultivars autochthonous of the Emilia‐Romagna region (Nostrana di Brisighella and Ghiacciolo), selected as representatives of 14 geographical sites (small farms) with different characteristics in terms of climatic and environmental conditions (e.g., altitude, geographical orientation and slope of the olive orchard) of the production area established in the product specification. These results are also compared with available data of EVOOs certified as PDO Brisighella in the period 2004–2012 and commissioned by the responsible certification control body.Practical Application: The product specification represents the product's identification document that must contain a description of the requirements that the product must comply with (e.g., product description in terms of chemical and sensory characteristics, delimitation of geographical area and evidence of the link with the territory, methodology applied, etc.). It also must include the references relative to control systems; therefore, amendments according to the updating of EU legislation in the sector are desirable to assure the final consumer that the expected value of the product effectively corresponds with what has been declared. Moreover, considering the growing interest of consumers toward health properties, this update will contribute to communicating the intrinsic properties of olive oil and benefits to health, enhancing the product image and promoting informed consumption.Recent amendment to product specification of Brisighella PDO (Emilia‐Romagna, Italy). Considering the growing interest of consumers toward health properties, this update will contribute to communicate the intrinsic properties of olive oil and benefits to health, enhancing the product image, and promoting informed consumption.
Optimized Analysis of MCPD‐ and Glycidyl Esters in Edible Oils and Fats Using Fast Alkaline Transesterification and13C‐Correction for Glycidol Overestimation: Validation Including Interlaboratory Comparison
Authors: Zwagerman Ralph , Overman Pierre 
Published: January 2019

As of March 2018, legislation has come into force within the European Union (EU) that places maximum levels on the glycidyl ester (GE) content of vegetable oils intended for use in foodstuffs for the European market. As a result, producers of edible oils are obliged to closely monitor the GE levels in all their products. Unfortunately, the three available AOCS methods to measure GE are not really suited for application in a quality control (QC) laboratory within a production facility, where short turnaround times are vital. AOCS Cd29c‐13 has the highest potential from a turnaround perspective, but remains disputable because it is based on a differential GE measurement. Hence, in 2016 the authors published an automated procedure in which the shortcomings of the AOCS Cd29c‐13 are effectively addressed. This article presents the results of an interlaboratory comparison, which is organised across six laboratories in four countries. Methods involved include AOCS Cd29b‐13 as well as an optimized version of the 2016 method, which is carried out both automatically and manually. Prior to validation, several optimizations are implemented to further reduce turnaround time and improve robustness of the original method. Based on the results of the interlaboratory comparison, it is concluded that the automated procedure performs slightly better than the manual alternative. Compared to the AOCS Cd29b‐13, no significant differences are observed for various types and blends of vegetable oils.Practical Application: Because the EU has recently enforced its legislation for maximum GE levels in edible oils, QC laboratories across the EU are looking for methods which are easily implemented. In practice, this implies high quality, low costs and high sample capacity. Food safety demands fast and reliable analysis in order to verify the quality of refined edible oils and fats. Due to the toxicological relevance of these process contaminants, turnaround time is a crucial performance parameter and any possibility of reducing analysis time has to be fully exploited. The method presented here, provides the short turnaround times required for these purposes and is validated by interlaboratory comparison. This is crucial in the coming years when new EU legislation as well as efforts by food companies will continue to push the continuation of mitigation efforts by edible oil producers.Graphical overview of serial versus parallel preparation of seven authentic samples and the profound effect on the total sample preparation time required for the analysis of MCPDe and GE in edible oils.
microRNA‐27a and microRNA‐146aSNPin cerebral malaria
Authors: Wah Saw Thu , Hananantachai Hathairad , Patarapotikul Jintana , Ohashi Jun , Naka Izumi , Nuchnoi Pornlada 
Published: January 2019

AbstractBackgroundDuringPlasmodium falciparuminfection, microRNAexpression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. MicroRNAregulates gene expression post‐transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the immunological disorder. We hypothesize that single‐nucleotide polymorphism in a microRNAinfluences microRNAbiogenesis or target gene recognition and altering susceptibility to cerebral malaria.MethodsWe performed a literature search based on immunological mechanism and applied microRNA‐related single‐nucleotide polymorphisms database to examine candidate microRNA SNPs possibly responsible for cerebral malaria. MicroRNA‐27a and microRNA‐146a are supposed to involve in cerebral malaria pathology. To assess the relationship of microRNA SNPto cerebral malaria outcome, we performed TaqMan Genotyping Assays in 110 cerebral malaria and 207 uncomplicated malaria cases for three candidate microRNA SNPs (rs895819 of microRNA‐27a, rs57095329 and rs2910164 of microRNA‐146a).ResultsOur study detected no significant difference in genotype and allele frequency of individual microRNA SNPs as well as in haplotypes of microRNA‐146a between these two groups of malaria patients in Thailand. Hardy–Weinberg disequilibrium of rs57095329 in the cerebral malaria group showed a heterozygous excess which might be due to natural selection.ConclusionOur data supported that the candidate microRNA SNPs have no major role to develop cerebral malaria.
The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype
Authors: Kolli Sai , Bojic Sanja , Ghareeb Ali E. , Kurzawa-Akanbi Marzena , Figueiredo Francisco C. , Lako Majlinda 
Published: January 2019

Abstract
Nerve growth factor (NGF) has demonstrated great benefit in the treatment of neurotrophic corneal ulcers. There is evidence for multiple modes of action in promoting corneal healing, but only indirect evidence exists for NGF's effects on limbal stem cells (LSCs). Understanding the role of NGF in LSC biology will improve our understanding of paracrine regulation of the limbal niche and the design of stem cell-based therapies for conditions such as LSC deficiency. In this article, we studied the regulation of NGF signaling components during LSC differentiation and the role of NGF in LSC proliferation and maintenance of the stem cell phenotype. LSC differentiation was induced by prolonged (40 day) culture which resulted in a significant increase in cell size, decrease in colony-forming efficiency and expression of putative LSC markers. A protein microarray measuring expression of 248 signaling proteins indicated the low affinity NGF receptor p75NTR to be the most downregulated protein upon differentiation. Further confirmation by Western blotting and real-time quantitative polymerase chain reaction indicated that NGF and p75NTR are expressed in early LSC cultures and downregulated upon differentiation. LSC cultures grown in the presence of anti-NGF antibody showed decreased colony-forming efficiency, DNA replication and expression of putative LSC markers ABCG2 and C/EBPδ. Supplementation of LSC culture medium with NGF extended the life span of LSC cultures in vitro and increased the expression of putative LSC markers ΔNp63α and ABCG2. Taken together, our data indicate that NGF signaling is a key promoter of LSC proliferation, colony-forming efficiency, and a maintainer of the LSC phenotype. Stem Cells 2019;37:139–149
Bioenergetic Changes Underline Plasticity of Murine Embryonic Stem Cells
Authors: Vlaski-Lafarge Marija , Loncaric Darija , Perez Laura , Labat Véronique , Debeissat Christelle , Brunet de la Grange Philippe , Rossignol Rodrigue , Ivanovic Zoran , Bœuf Hélène 
Published: January 2019

Abstract

Murine embryonic stem cells (mESCs) are endowed by a time-dependent window of plasticity during their early commitment steps. Indeed, while mESCs deprived of leukemia inhibitory factor (LIF) for 24 hours revert to their naive pluripotent state after subsequent LIF readdition, cells deprived of LIF for 48 hours are no longer efficient in reverting, upon LIF addition, and undergo irreversible differentiation. We investigated undisclosed bioenergetic profiles of early mESC-derived committed cells versus their undifferentiated states in order to reveal specific bioenergetic changes associated with mESC plasticity. Multiparametric bioenergetic analysis revealed that pluripotent (+LIF) and reversibly committed cells (−LIF24h) are energetically flexible, depending on both oxidative phosphorylation (OXPHOS) and glycolysis. They exhibit high mitochondrial respiration in the presence of the main energetic substrates and can also rely on glycolysis in the presence of OXPHOS inhibitor. Inhibition of the glycolysis or mitochondrial respiration does not change drastically the expression of pluripotency genes, which remain well expressed. In addition, cells treated with these inhibitors keep their capacity to differentiate efficiently upon embryoid bodies formation. Transition from metabolically active mESCs to irreversibly committed cells is associated with a clear change in mitochondrial network morphology, to an increase of adenosine triphosphate (ATP) produced from glycolysis and a decline of ATP turnover and of the mitochondrial activity without change in the mitochondrial mass. Our study pointed that plasticity window of mESCs is associated with the bivalent energetic metabolism and potency to shift to glycolysis or OXPHOS on demand. LIF removal provokes glycolytic metabolic orientation and consecutive loss of the LIF-dependent reversion of cells to the pluripotent state. Stem Cells 2019;37:463–475