bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis and Therapeutic Potential of Some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
Authors: Kumar Sanjiv , Narasimhan Balasubramanian , Lim Siong Meng , Ramasamy Kalavathy , Mani Vasudevan , Shah Syed Adnan Ali 
Published: December 2018

<P>Background: A series of 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)
derivatives has been synthesized by Claisen-Schmidt condensation and its chemical structures was
confirmed by FT-IR, 1H/13C-NMR spectral and elemental analyses. The molecular docking study was
carried out to find the interaction between active bis-pyrimidine compounds with CDK-8 protein. The
in vitro antimicrobial potential of the synthesized compounds was determined against Gram-positive
and Gram-negative bacterial species as well fungal species by tube dilution technique. Antimicrobial
results indicated that compound 11y was found to be most potent one against E. coli (MICec = 0.67
µmol/mL) and C. albicans (MICca = 0.17 µmol/mL) and its activity was comparable to norfloxacin
(MIC = 0.47 µmol/mL) and fluconazole (MIC = 0.50 µmol/mL), respectively.

Conclusion:
Anticancer screening of the synthesized compounds using Sulforhodamine B (SRB) assay
demonstrated that compounds 2y (IC50 = 0.01 µmol/mL) and 4y (IC50= 0.02 µmol/mL) have high antiproliferative
potential against human colorectal carcinoma cancer cell line than the reference drug (5-
fluorouracil) and these compounds also showed best dock score with better potency within the ATP
binding pocket and may also be used lead for rational drug designing.</P>
Changes in Scaphoid and Lunate Position and Loading at Two Wrist Pushup Positions
Authors: Werner Frederick W. , Tucci Emily R. , Daly Brett T. , Harley Brian J. 
Published: December 2018

Background:
Scapholunate interosseous ligament (SLIL) injury following a fall on an
outstretched hand may lead to carpal instability and in some cases require long-term rehabilitation
following repair. Rehabilitation, especially in athletes, may include pushups, but little is known as
to what type of pushup may be safer.

Objective:
To determine biomechanical differences between two pushup positions (neutral or extended).

Methods:
Six fresh cadaver wrists with pre-existing SLIL damage were uni-axially loaded in neutral
and extension in order to simulate two different pushup styles. The motions of the scaphoid and
lunate in relation to the radius were measured. The dorsal, proximal, and volar insertion sites of the
SLIL were identified and, using the collected kinematic data, gap distances were calculated for
each site.

Conclusion:
The larger gap distances between the scaphoid and lunate in neutral suggest that a
neutral style pushup could put higher forces on a wrist with pre-existing SLIL damage and may
thus hinder recovery for a person with a repaired SLIL. A pushup in extension, in these injured
wrists, may be less detrimental.
DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design and Synthesis
Authors: Khalaf Reema A. , Masalha Dalal , Sabbah Dima 
Published: December 2018

Background:
Lately, diabetes has become the main health concern for millions of people around
the world. Dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged as a new class of oral antidiabetic
agents. Formerly, acridines, N4-sulfonamido-succinamic, phthalamic, acrylic and benzoyl acetic acid derivatives,
and sulfamoyl-phenyl acid esters were designed and developed as new DPP-IV inhibitors.

Objective:
This study aims to develop a pharmacophore model of DPP-IV inhibitors and to evaluate phenanthridines
as a novel scaffold for inhibiting DPP-IV enzyme. In addition, to assess their binding interactions
with the enzyme through docking in the binding site of 4A5S (PDB).

Methods:
Herein, Quantum–Polarized Ligand Docking (QPLD) and ligand-based pharmacophore modeling
investigations were performed. Three novel 3,8-disubstituted-6-phenyl phenanthridine derivatives 3-5 have
been designed, synthesized and characterized. In vitro biological testing against DPP-IV was carried out using
fluorometric assay kit.

Results:
QPLD study demonstrates that compounds 3-5 forms H-bond with Lys554, Trp629, and Tyr631,
besides charge transfer interaction between their aromatic rings and the aromatic rings of Tyr547 and
Tyr666. Moreover, they fit the three pharmacophoric point features of DPP-IV inhibitors and were proven
to have in vitro DPP-IV inhibitory activity where compound 5 displayed a % inhibition of 45.4 at 100 μM
concentration.

Conclusion:
Phenanthridines may serve as a potential lead compound for developing new DPP-IV inhibitors
as a promising antidiabetic agent. Computational results suggest future structural simplification.
Population-Based Study of Risk of AKI with Levetiracetam
Authors: Yau Kevin , Burneo Jorge G. , Jandoc Racquel , McArthur Eric , Muanda Flory Tsobo , Parikh Chirag R. , Wald Ron , Weir Matthew A. , Garg Amit X. 
Published: December 2018

Background and objectives
Regulatory agencies warn about the risk of AKI with levetiracetam use on the basis of information from case reports. We conducted this study to determine whether new levetiracetam use versus nonuse is associated with a higher risk of AKI.

Design, setting, participants, & measurements
This was a population-based retrospective cohort study of adults with epilepsy in Ontario, Canada. Patients who received a new outpatient prescription for levetiracetam between January 1, 2004 and March 1, 2017 were matched to two nonusers on stage of CKD, recorded seizure in the prior 90 days, and logit of a propensity score for levetiracetam use. The primary outcome was a hospital encounter (emergency department visit or hospitalization) with AKI within 30 days of cohort entry. Secondary outcomes were AKI within 180 days and change in the concentration of serum creatinine. We assessed the primary outcome using health care diagnosis codes. We evaluated the change in the concentration of serum creatinine in a subpopulation with laboratory measurements.

Results
We matched 3980 levetiracetam users to 7960 nonusers (mean age 55 years, 51% women). Levetiracetam use was not significantly associated with a higher risk of AKI within 30 days (13 [0.33%] events in levetiracetam users and 21 [0.26%] events in nonusers [odds ratio, 1.24; 95% confidence interval, 0.62 to 2.47]). Similarly, there was no significant association with AKI within 180 days (odds ratio, 0.70; 95% confidence interval, 0.43 to 1.13). The change in the concentration of serum creatinine did not significantly differ between levetiracetam users and nonusers.

Conclusions
In this population-based study levetiracetam use was not associated with a higher risk of AKI.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_12_11_Yau_Podcast.mp3
Ensino de repertórios requisitos e os efeitos sobre comportamentos incompatíveis com aprendizagem em crianças com Transtorno do Espectro Autista
Authors: Guerra Barbara Trevizan 
Published: December 2018

Pessoas com Transtorno do Espectro Autista (TEA) podem apresentar déficits significativos no repertório básico requisito para receber programas de ensino e se engajar com frequência em comportamentos repetitivos e inadequados. Considerando-se que tais comportamentos são incompatíveis com o ensino e resultam em consequências negativas, sejam sociais e/ou acadêmicas, esta pesquisa teve por objetivo ensinar sistematicamente operantes requisitos, como sentar, permanecer sentado, olhar, imitar, imitação generalizada e rastreamento visual para duas crianças com TEA, e verificar o efeito do procedimento sobre os comportamentos inadequados e estereotipias. Os resultados demonstraram que um participante aprendeu todos os comportamentos alvo de ensino enquanto o outro não atingiu o critério de aprendizagem em imitação. Houve redução dos comportamentos incompatíveis com a aprendizagem, logo após a introdução das contingências para os comportamentos de ensino, para ambos. Os resultados demonstram a aquisição de repertórios requisitos importantes em crianças com TEA severo e demonstram que a redução de comportamentos incompatíveis com aprendizagem pode ocorrer mediante ensino de comportamentos desejados.
EVALUASI KESESUAIAN PERAIRAN UNTUK BUDIDAYA IKAN BETUTU Oxyeleotris marmorata (BLEEKER, 1852) DI DESA RANTAU JAYA MAKMUR SUNGAI WAY PEGADUNGAN KECAMATAN PUTRA RUMBIA KABUPATEN LAMPUNG TENGAH
Authors: Diantari Rara , Damai Abdullah Aman , Pratiwi Leoni Dian 
Published: December 2018

Way Pegadungan is a tributary of Way Seputih, has a length of 35.31 km and a river width of 50 to 70 meters. Way Pegadungan is very potential for aquaculture but has not been used optimally. This research was held in March - May 2018 using a descriptive quantitative method aimed at assessing the level of suitability of the waters by knowing the physical and chemical parameters for the cultivation of betutu fish. The data used primary data, namely the parameters of water suitability in the form of water quality values, while the secondary data is in the form of research location maps. Water suitability analysis was carried out using matching and scoring methods. The range of data obtained is depth: 6-7 m, brightness: 37,5-55 cm, temperature: 28-29ºC, pH: 7-8,21, dissolved oxygen: 4,02-6,73 mg / l, current : 0,14-0,16 m / s, nitrate: 0,16-0,21 mg / l, phosphate: 0,01-0,025 mg / l, ammonia: 0,01-0,065 mg / l, organic matter: 6,7-10,76 mg / l. Sampling stations were 4 stations determined by the global positioning system (GPS). At the first and fourth points get moderately sutable (S2) and at the second and third points get marginal sutable (S3).
Perbedaan Individual Mahasiswa dalam Mata Kuliah Pengantar Akuntansi 1 dan Implikasinya dalam Pembelajaran
Authors: Rahmi Elvi 
Published: December 2018

The objective of this study is to descript the individual students differences in the Introduction to Accounting 1 course and how is the implications in learning process. This study uses a quantitative descriptive approach. The population is all of students of the Department of Economics, who took Accounting Introduction 1 course, during The period from July to December 2018, and the sample are 32 students. Data were analyzed using descriptive analysis. Research results showed that students had different educational backgrounds who came from Senior High School majoring in Science, Senior High School majoring in Social Sciences, Vocational High School majoring in Accounting and Vocational High School not majoring in Accounting, From research data, it is also known that there are differences in the ability of students to take part in Accounting learning and only 33.33 % of students who are interested will choose accounting as their choice of expertise. From the results of the study it was suggested to the lecturers who supervise the Accounting Introduction 1 to use multi instructional methods so that individual student differences can be minimized.
Assessment of EU banking network regionalization during post-crisis period
Authors: Gaigaliene Asta , Jurakovaite Otilija , Legenzova Renata 
Published: December 2018

Research background: Recent financial crisis of 2007?2008 has influenced global banking system and led to reduction of cross-border bank lending in the EU and worldwide. Global banking network has been analysed extensively in prior or post-crisis periods, but the literature on regionalization is scarce, especially with regard to the banking sector in the EU. Moreover, in previous empirical research evaluation of banking sector regionalization using network analysis methodology has not been yet applied.
Purpose of the article: The aim of the article is to map the EU banking network and to assess its regionalization during post-crisis period.
Methods: the paper employs comparative literature analysis and synthesis; BIS bilateral interbank cross-border claim yearly flows matrix data and network analysis method (including network mapping, structural and comparative analysis and the data of intraregional and interregional banking network matrices) to assess the changes in regionalization of the EU banking system.
Findings & Value added: The results of the research show that during post-crisis period both, EU 12 and EU 28, banking networks became more clustered and more decentralized; also the level of regionalization within the EU banking network increased. Such results prove that the EU banking network has undergone structural changes with respect to bilateral interbank cross-border claims. This research adds to the knowledge of regionalization processes within the EU banking network during the post-crisis period and intends to be beneficial for market participants, EU level governmental bodies and financial policy makers.
Changes in the global art market
Authors: Bialynicka-Birula Joanna 
Published: December 2018

Research background: The dynamics of the art market are usually presented in terms of price fluctuations, price indexes and financial returns. This paper proposes the value and volume approach, which has not been considered in an aggregative way for a long time in the economic literature.
Purpose of the article: The aim of the paper is to present changes in the global art market in the period 2002?2015. The results of dynamic analysis of the art market are presented, including two approaches: value of transactions and volume of transactions. The impact of the global crisis on the art market is considered.
Methods: In order to present the changes on the global art market, statistical indexes of dynamics (single base and chain indexes) are used. Moreover, trend analyses have been conducted for the value and volume of transactions on the art market. The sources of data on the global art market are from Artprice, ArtTactic, and TEFAF (The European Fine Art Foundation).
Findings & Value added: In the analysed period of 2002?2015, sales on the global art market generally increased. The value and volume of sales peaked in 2007 and 2014. The art market was considerably affected by the economic recession in 2009, but in the next year it recovered. The trend analyses allow the changes on the market to be described by means of mathematical functions, and the countries with the largest share in the global art market can be identified. Particular attention has been paid to the existence of a triad on the art market consisting of Europe, the USA and China. It is noteworthy that Europe and the USA have rapidly lost market share to China.
Estado de exceção como regra: a vida nua sob o “eclipse político” em Giorgio Agamben / State of exception as a rule: the bare life under the "political eclipse" in Giorgio Agamben
Authors: Oliveira Maria Do Socorro Catarina de Sousa 
Published: December 2018

Um dos temas de maior relevância abordado por Giorgio Agamben diz respeito ao estado de exceção como paradigma político, ou seja, o estado de exceção não se restringe aos Estados totalitários, mas a uma prática governamental que vem se propagando rapidamente, inclusive nas sociedades democráticas. Assim, o presente artigo tem como objetivo analisar, a partir de duas obras que compõem o Projeto Homo Sacer, a saber, Homo Sacer: o poder soberano e a vida nua I (2002), e Estado de Exceção: homo sacer II (2004), os principais elementos que formatam a teoria agambeniana do estado de exceção como paradigma de governo e como o delineamento de suas teses nos permite falar em “eclipse político”, o qual está concretizado na impotência do cidadão diante do poder soberano, a figura híbrida que tem a sua disposição não apenas a máquina governamental, mas o próprio ordenamento jurídico desvirtuado de seu objetivo original de proteção e segurança jurídica para um complexo e malicioso mecanismo de manutenção da “ordem social”. AbstractOne of the most relevant topics addressed by Giorgio Agamben is the state of exception as a political paradigm, that is, the state of exception is not restricted to totalitarian states, but to a government practice that is spreading rapidly, even in democratic societies. Thus, this article aims to analyze, from two works that make up the Homo Sacer Project, namely Homo Sacer: sovereign power and naked life I (2002), and State of Exception: homo sacer II (2004) ), the main elements that form the agambenian theory of the state of exception as a paradigm of government and how the delineation of its theses allows us to speak in "political eclipse", which is concretized in the impotence of the citizen before the sovereign power, the hybrid figure which has at its disposal not only the governmental machine, but the legal system itself distorted from its original objective of protection and legal security for a complex and malicious mechanism of maintenance of the "social order".
Neoliberalismo e democracia que resta: uma análise desde o caso brasileiro / Neoliberalism and democracy that remains: an analysis from the brazilian case
Authors: Amaral Augusto Jobim do 
Published: December 2018

A crise democrática por que passa o Brasil, há algum tempo, em alguma medida conjugada com os efeitos do neoliberalismo em escala global, pode ser lida como o último momento das esquerdas no poder no século XX. Não obstante, é necessário recorrer, de maneira autocrítica, as escolhas políticas realizadas pelos governos no país nos últimos anos para localizar os equívocos e, principalmente, o esgotamento de uma governabilidade que insiste nos limites da democracia representativa gerida pela lógica do capital. AbstractThe democratic crisis that has been going on for some time in Brazil, to some extent coupled with the effects of neoliberalism on a global scale, can be read as the last moment of the lefts in power in the twentieth century. Nevertheless, it is necessary to resort, in a self-critical way, to the political choices made by the governments in the country in recent years to locate the misunderstandings and, above all, the exhaustion of a governability that insists on the limits of representative democracy managed by the logic of capital.
Higher in-hospital mortality during weekend admission for acute coronary syndrome: a large-scale cross-sectional Italian study
Authors: Malanchini Giovanni , Stefanini Giulio Giuseppe , Malanchini Margherita , Lombardi Federico 
Published: December 2018

Aims
An increased mortality risk during weekend hospital admission has been consistently observed. In the present study, we evaluated whether the current improvement in management of acute coronary syndromes (ACS) has reduced this phenomenon.

Methods and results
We extracted data from the Italian National Healthcare System Databank of 80 391 ACS admissions in the region of Lombardia between 2010 and 2014. ICD-9 codes were used to assess the diagnosis. We performed a multiple logistic regression analysis to compare the mortality rates between weekend and weekday admissions.
Mean age of the study population was 67.6 years; 30.1% of patients were women. ST segment elevation myocardial infarction (STEMI) accounts for 42.2% of admissions. The total in-hospital mortality was 3.05% and was positively predicted by weekend admission [odds ratio (OR) 1.13, P = 0.006], age and female sex. The weekend effect on mortality was only significant for STEMI (OR 1.11, P = 0.04) in comparison to non-STEMI (NSTEMI) or unstable angina.
The trend of the risk of death was found to be negatively correlated with age: the risk of death was significantly higher in all age clusters younger than 75 (OR 1.22, P < 0.01) and even greater in the very young subgroup under 45 years of age (OR 2.09, P = 0.03).

Conclusion
Our data indicate that increased mortality risk is still present during weekend admissions. This phenomenon is particularly evident in younger patients and in individuals admitted for STEMI.
GREBEG MAULUD DALAM REPRESENTASI BUSANA DAN MOTIF BATIK DI KERATON YOGYAKARTA
Authors: Hasan Renta Vulkanita 
Published: December 2018

Culture growing in Indonesia and overseas intrinsically dynamic. Nature of culture as a result ofhuman creativity is always moving and displacement. When his journey to the vibrant place anyway,culture is likely to mix with the native culture which then grow and develop into a new culture.Culture is a strong factor that affects the mindset. Over time, society has a way of looking at theworld deal, behave, and interact with each other. In other words, they have their own color andpattern of the deal while making rules in social life. Yogyakarta in Java, which is known as one of thecultural centers of Java development, especially ritual Grebeg Maulud. Ritual Grebeg Maulud overtime reflecting the constantly changing movement of social change, culture, politics, economics andsociety in his day. Ritual is a means of connecting Grebeg Maulud transcendental between man andGod (Manunggaling Kawula-Gusti) and guidance from the teachings of the holy book (Islam). But thistime Grebeg Maulud also has another function, namely as a spectacle. This suggests a cultural shiftfrom the sacred to the profane. Batik as a dress code in the Carnival celebrations Grebeg Maulud isone reflection of the existence of culture in Yogyakarta Palace. The use of batik in a ritual processionGrebeg Maulud is a tradition that continues to this day. Batik palace is considered one of the symbolsof the existence of power relations by creating a specific motive for a particular class. Dynamism ofculture led to the use of batik is not only a marker of power relations, but also as an exciting treat forthe fashion show at the Carnival lasts Grebeg Maulud. Keyword: Grebeg, Maulud, representations, clothing, batik, palace, Yogyakarta
Hubungan Antara Self-Esteem dengan Smartphone Addiction pada Remaja SMA di Kota Banda Aceh
Authors: Mulyana Sri , Afriani Afriani 
Published: December 2018

Smartphone addiction merupakan fenomena yang rentan terjadi pada remaja, dan memberikan dampak buruk terhadap perkembangan fisik dan psikologis mereka. Salah satu faktor yang berpengaruh terhadap terjadinya smartphone addiction pada remaja adalah harga diri. Tujuan penelitian ini adalah untuk mengetahui hubungan antara harga diri dengan smartphone addiction pada remaja Sekolah Menengah Atas di Kota Banda Aceh. Sebanyak 336 remaja dari 4 sekolah di kota Banda Aceh dipilih sebagai subjek dalam penelitian ini menggunakan teknik multistage cluster dan disproportionate stratified random sampling. Pengumpulan data dalam penelitian ini menggunakan Rosenberg Self Esteem Scale dan Smartphone Addiction Scale Short Version. Analisis data menggunakan teknik korelasi pearson menunjukkan bahwa terdapat hubungan yang signifikan dan negatif antara harga diri dengan smartphone addiction (r = -0,145, p<0,05). Hal ini menunjukkan bahwa semakin tinggi skor harga diri maka semakin rendah skor pada smartphone addiction pada remaja SMA di Banda Aceh, demikian pula sebaliknya. Dengan demikian, dapat disimpulkan bahwa remaja dengan harga diri tinggi memiliki kemungkinan yang lebih rendah untukÂ mengalami smartphone addiction.