bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased weighting on prior knowledge in Lewy body-associated visual hallucinations
Authors: Zarkali Angeliki , Adams Rick A , Psarras Stamatios , Leyland Louise-Ann , Rees Geraint , Weil Rimona S 
Published: July 2019

Abstract
Hallucinations are a common and distressing feature of many psychiatric and neurodegenerative conditions. In Lewy body disease, visual hallucinations are a defining feature, associated with worse outcomes; yet their mechanisms remain unclear and treatment options are limited. Here, we show that hallucinations in Lewy body disease are associated with altered integration of top-down predictions with incoming sensory evidence, specifically with an increased relative weighting of prior knowledge. We tested 37 individuals with Lewy body disease, 17 habitual hallucinators and 20 without hallucinations, and 20 age-matched healthy individuals. We employed an image-based learning paradigm to test whether people with Lewy body disease and visual hallucinations show higher dependence on prior knowledge. We used two-tone images that are difficult to disambiguate without any prior information but generate a strong percept when information is provided. We measured discrimination sensitivity before and after this information was provided. We observed that in people with Lewy body disease who experience hallucinations, there was greater improvement in discrimination sensitivity after information was provided, compared to non-hallucinators and controls. This suggests that people with Lewy body disease and hallucinations place higher relative weighting on prior knowledge than those who do not hallucinate. Importantly, increased severity of visual hallucinations was associated with an increased effect of prior knowledge. Together these findings suggest that visual hallucinations in Lewy body disease are linked to a shift towards top-down influences on perception and away from sensory evidence, perhaps due to an increase in sensory noise. This provides important mechanistic insights to how hallucinations develop in Lewy body disease, with potential for revealing new therapeutic targets.
Blind Submission
Authors: Bahrainwala Lamiyah 
Published: July 2019

AbstractMuslims in the West are under pressure to perform nationalism and hegemonic gender ideology to neutralize themselves as threats. This has triggered a series of “blindfolded hug” viral videos that show individual Muslim males standing blindfolded in a busy street asking for hugs from passersby who “agree” that they are not a danger to society. In this article, I examine 51 such videos and argue that the visual of a minority male made abject reifies state might while building an aesthetic of peacefulness that Western Muslims are compelled to demonstrate. Such an aesthetic relies on the rhetorics of disability, the affective circulation of hate, and the stripping off of oppositional gazing to be read legibly by White audiences.
Urine Tenofovir Concentrations Correlate With Plasma and Relate to Tenofovir Disoproxil Fumarate Adherence: A Randomized, Directly Observed Pharmacokinetic Trial (TARGET Study)
Authors: Drain Paul K , Kubiak Rachel W , Siriprakaisil Oraphan , Klinbuayaem Virat , Quame-Amaglo Justice , Sukrakanchana Pra-Ornsuda , Tanasri Suriyan , Punyati Pimpinun , Sirirungsi Wasna , Cressey Ratchada , Bacchetti Peter , Okochi Hideaki , Baeten Jared M , Gandhi Monica , Cressey Tim R 
Published: July 2019

Abstract

Background
Direct measurement of tenofovir (TFV) in urine could be an objective measure to monitor adherence to preexposure prophylaxis (PrEP) or TFV-based antiretroviral therapy (ART).

Methods
We conducted a 3-arm randomized, pharmacokinetic study of tenofovir disoproxil fumarate (TDF) 300 mg/emtricitabine (FTC) 200 mg among adults living with human immunodeficiency virus. Participants were randomized to receive controlled TDF/FTC dosing as (1) “perfect” adherence (daily); (2) “moderate” adherence (4 doses/week); or (3) “low” adherence (2 doses/week). We obtained trough spot urine and plasma samples during a 6-week directly observed therapy period and a 4-week washout period. TFV concentrations were compared between adherence arms using 1-way analysis of variance.

Results
Among 28 participants, the median age was 33 years and 16 (57%) were male. Correlation between TFV plasma and urine concentrations was strong (ρ = 0.78; P &lt; .0001). Median (interquartile range) steady-state trough TFV concentrations (ng/mL) for perfect, moderate, and low TDF adherence were 41 (26–52), 16 (14–19), and 4 (3–5) in plasma; and 6480 (3940–14 300), 3405 (2210–5020), and 448 (228–675) in urine. Trough TFV concentrations at steady state were significantly different between the 3 adherence arms for plasma (P &lt; .0001) and urine (P = .0002). Following drug cessation, TFV concentrations persisted longer in urine than plasma samples. Washout urine TFV concentrations and time to undetectable concentrations did not differ between the 3 randomized adherence groups.

Conclusions
Urine TFV concentrations can inform interpretation of novel point-of-care urine-based TFV assays to assess recent TDF adherence.

Clinical Trials Registration
NCT0301260.
Algorithm in the Diagnosis of Febrile Illness Using Pathogen-specific Rapid Diagnostic Tests
Authors: Pokharel Sunil , White Lisa J , Aguas Ricardo , Celhay Olivier , Pellé Karell G , Dittrich Sabine 
Published: July 2019

Abstract

Background
In the absence of proper guidelines and algorithms, available rapid diagnostic tests (RDTs) for common acute undifferentiated febrile illnesses are often used inappropriately.

Methods
Using prevalence data of 5 common febrile illnesses from India and Cambodia, and performance characteristics (sensitivity and specificity) of relevant pathogen-specific RDTs, we used a mathematical model to predict the probability of correct identification of each disease when diagnostic testing occurs either simultaneously or sequentially in various algorithms. We developed a web-based application of the model so as to visualize and compare output diagnostic algorithms when different disease prevalence and test performance characteristics are introduced.

Results
Diagnostic algorithms with appropriate sequential testing predicted correct identification of etiology in 74% and 89% of patients in India and Cambodia, respectively, compared with 46% and 49% with simultaneous testing. The optimally performing sequential diagnostic algorithms differed in India and Cambodia due to varying disease prevalence.

Conclusions
Simultaneous testing is not appropriate for the diagnosis of acute undifferentiated febrile illnesses with presently available tests, which should deter the unsupervised use of multiplex diagnostic tests. The implementation of adaptive algorithms can predict better diagnosis and add value to the available RDTs. The web application of the model can serve as a tool to identify the optimal diagnostic algorithm in different epidemiological settings, while taking into account the local epidemiological variables and accuracy of available tests.
Strong population structure and limited gene flow between Yellow-billed Ducks and Mallards in southern Africa
Authors: Brown Joshua I , Lavretsky Philip , Cumming Graeme S , Peters Jeffrey L 
Published: July 2019

AbstractSecondary contact and hybridization between recently diverged taxa have been increasing due to anthropogenic changes to the environment. Determining whether secondary contact leads to gene flow between species is important for understanding both the evolutionary consequences of such events (i.e. genetic swamping, speciation reversal, hybrid speciation) and for establishing proper conservation measures. Mallards (Anas platyrhynchos), which natively have a Holarctic distribution, have been introduced nearly worldwide due to game-farm and domestic pet releases. Their expanding range has resulted in secondary contact and increased incidences of hybridization with many closely related Mallard-like ducks that comprise the Mallard complex. Here, we assay molecular diversity for 19 nuclear introns and the mitochondrial DNA for wild Mallards (n = 50) across their Holarctic range and Yellow-billed Ducks (n = 30–75; Anas undulata) from southern Africa to determine population genetic structure and test for evidence of Mallard introgression into Yellow-billed Ducks. While we found limited support for contemporary gene flow across nuclear markers, we provide evidence from mitochondrial DNA that best supports ancient gene flow between Yellow-billed Ducks and Mallards. Yellow-billed Ducks best fit a single population at nuclear markers but show some location-specific mtDNA structure that suggests recent founder or bottleneck events. Although we find that introgression from Mallards into Yellow-billed Duck is limited, Yellow-billed Duck populations should be monitored to determine if expanding feral Mallard populations in southern Africa are increasing introgression.
Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
Authors: Manti Maria , Fornes Romina , Pironti Gianluigi , McCann Haworth Sarah , Zhengbing Zhuge , Benrick Anna , Carlström Mattias , Andersson Daniel , Stener-Victorin Elisabet 
Published: July 2019

Abstract

Aims
Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to increase the risk for cardiovascular disease. How PCOS may lead to adverse cardiac outcomes is unclear and here we hypothesized that prenatal exposure to dihydrotestosterone (DHT) and/or maternal obesity in mice induce adverse metabolic and cardiac programming in female offspring that resemble the reproductive features of the syndrome.

Methods and results
The maternal obese PCOS phenotype was induced in mice by chronic high-fat–high-sucrose consumption together with prenatal DHT exposure. The prenatally androgenized (PNA) female offspring displayed cardiac hypertrophy during adulthood, an outcome that was not accompanied by aberrant metabolic profile. The expression of key genes involved in cardiac hypertrophy was up-regulated in the PNA offspring, with limited or no impact of maternal obesity. Furthermore, the activity of NADPH oxidase, a major source of reactive oxygen species in the cardiovascular system, was down-regulated in the PNA offspring heart. We next explored for early transcriptional changes in the heart of newly born PNA offspring, which could account for the long-lasting changes observed in adulthood. Neonatal PNA hearts displayed an up-regulation of transcription factors involved in cardiac hypertrophic remodelling and of the calcium-handling gene, Slc8a2. Finally, to determine the specific role of androgens in cardiovascular function, female mice were continuously exposed to DHT from pre-puberty to adulthood, with or without the antiandrogen flutamide. Continuous exposure to DHT led to adverse left ventricular remodelling, and increased vasocontractile responses, while treatment with flutamide partly alleviated these effects.

Conclusion
Taken together, our results indicate that intrauterine androgen exposure programmes long-lasting heart remodelling in female mouse offspring that is linked to left ventricular hypertrophy and highlight the potential risk of developing cardiac dysfunction in daughters of mothers with PCOS.
Delimiting the Neoproterozoic São Francisco Paleocontinental Block with P-wave traveltime tomography
Authors: Rocha Marcelo Peres , Azevedo Paulo Araújo de , Assumpção Marcelo , Pedrosa-Soares Antônio Carlos , Fuck Reinhardt , Von Huelsen Monica Giannoccaro 
Published: July 2019

SummaryThe São Francisco Paleocontinental Block (SFPB) represents part of the Congo-São Francisco Paleocontinent (CSFP), amalgamated around 2 Ga. In the Neoproterozoic, a branched continental rift system evolved to ocean basins around most edges of the SFPB that remained only partially linked to the Congo Paleocontinent by means of the Bahia-Gabon Continental Bridge. After the Brasiliano—Pan-African orogeny, two relatively preserved CSFP sectors formed the São Francisco and Congo cratons, surrounded by Neoproterozoic orogenic belts. Recent results of upper mantle P-wave seismic tomography allowed us to suggest a delimitation in lithospheric depths of the Neoproterozoic SFPB, which comprise the São Francisco Craton, and that this would have been connected with the Congo Paleocontinent along the Araçuaí Belt. It is characterized by high-velocity anomalies and its boundaries with other blocks are marked by low-velocity anomalies at lithospheric depths. We tested the resolution of the tomographic results through synthetic models obtained by a ray tracing scheme using the observed ray configuration. We observe that the lateral resolution is adequate, but the method used was not able to set the depth reached by the SFPB. Our results indicate that the SFPB area in lithospheric depths is larger than the surface area ascribed to the São Francisco craton, and thus, the SFPB basement deeply extends beneath neighboring orogenic regions, suggesting that these Neoproterozoic mobile belts, such as Araçuaí Orogen and the Brasilia Fold Belt, reworked the continental crust. We observe a low-velocity anomaly in the SFPB central region, corresponding to the Pirapora aulacogen. Our results have a good spatial correspondence with the low Bouguer anomalies used to define the SFPB in previous studies. The limits of the SFPB are consistent with deviation of the mantle flow, as suggested by SKS fast polarization.
Homogenization of fault frictional properties
Authors: Ray Sohom , Viesca Robert C 
Published: July 2019

SUMMARY
The frictional properties of large faults are expected to vary in space. However, fault models often assume that properties are homogeneous, or nearly so. We investigate the conditions under which the details of variations may be neglected and properties homogenized. We do so by examining the behaviour of nonlinear solutions for unstably accelerating fault slip under frictional heterogeneity. We consider a rate- and state-dependent fault friction in which the characteristic wavelength for the property variations is a problem parameter. We find that homogenization is permissible only when that wavelength shows scale separation from an elasto-frictional length scale. However, fault models also often include property transitions that occur over distances comparable to the elasto-frictional length. We show that under such comparable variations, the dynamics of earthquake-nucleating instabilities is controlled by the properties’ spatial distribution.
Fertility preservation: should we reconsider the terminology?
Authors: Grynberg Michaël , Sermondade Nathalie 
Published: July 2019

Abstract
The term ‘fertility preservation’ embraces techniques that are actually mostly based on gamete and gonadal tissue cryopreservation. While the efficiency of these techniques in terms of live births remains difficult to establish, it is remarkable that this ambiguous terminology is routinely used and seems currently well accepted. In order to limit false hopes about the real chances of truly preserving fertility, our medical community should discuss qualifying the term ‘fertility preservation’. ‘Gamete or gonadal tissue cryopreservation’ could appear as a more unambiguous and realistic term. However, it probably captures only a segment of a more global ‘fertility preservation’ process. Discussing how and when to use which terminology, and even finding a more realistic and unifying term, should be further explored.
Left anterior descending artery revascularization with the right internal thoracic artery T-graft: the ‘reverse composite’ configuration
Authors: Ag-Rejuan Yael , Pevni Dmitry , Nesher Nachum , Kramer Amir , Paz Yosef , Mohr Rephael , Malamud Dorel , Ben-Gal Yanai 
Published: July 2019

Abstract

OBJECTIVES
The use of bilateral internal thoracic artery graft for myocardial revascularization has improved the long-term survival and decreased the rate of repeat interventions in patients. A key technical factor for complete arterial revascularization is sufficient length of the internal thoracic artery (ITA) graft. The purpose of this study was to compare early and long-term outcomes of ‘standard composite’ grafting and ‘reverse composite’ grafting. In the former, the left ITA (LITA) is connected to the left anterior descending artery, and the right ITA is connected end-to-side to the LITA for revascularization of the left circumflex artery. In ‘reverse composite’ grafting, the LITA is connected to the left circumflex artery, and the right ITA is connected end-to-side to the LITA, for revascularization of the left anterior descending artery.

METHODS
We compared the outcomes of 1365 patients who underwent coronary artery bypass grafting in Tel-Aviv Sourasky Medical Centre, using bilateral ITA as standard composite versus ‘reverse composite’ grafts, between January 1996 and December 2011. A propensity score matching analysis compared 132 pairs of patients who underwent bilateral ITA by the 2 modes.

RESULTS
Twelve hundred and thirty patients underwent standard ‘composite’ grafts and 135 underwent ‘reverse composite’ grafts. Early mortality and early adverse effects did not differ significantly between the groups. After matching, the difference in late mortality between the groups was not statistically significant.

CONCLUSIONS
This study suggests that revascularization of the left anterior descending with the right ITA, arising from an in situ LITA, is safe and provides early outcomes and long-term survival that are not significantly different from those of the standard composite grafting technique. However, there was evidence of better survival in the standard composite group.
The pattern speed of the Milky Way bar from transverse velocities
Authors: Sanders Jason L , Smith Leigh , Evans N Wyn 
Published: July 2019

ABSTRACT
We use the continuity equation to derive a method for measuring the pattern speed of the Milky Way’s bar/bulge from proper motion data. The method has minimal assumptions but requires complete coverage of the non-axisymmetric component in two of the three Galactic coordinates. We apply our method to the proper motion data from a combination of Gaia DR2 and VISTA Variables in the Via Lactea (VVV) to measure the pattern speed of the bar as $\Omega _\mathrm{p}=(41\pm 3)\, \mathrm{km\, s^{-1}\, kpc^{-1}}$ (where the error is statistical). This puts the corotation radius at $(5.7\pm 0.4)\, \mathrm{kpc}$, under the assumptions of the standard peculiar motion of the Sun and the absence of non-axisymmetric streaming in the Solar neighbourhood. The obtained result uses only data on the near side of the bar which produces consistent measurements of the distance and velocity of the centre of the Galaxy. Addition of the data on the far side of the bar pulls the pattern speed down to $\Omega _\mathrm{p}=(31\pm 1)\, \mathrm{km\, s^{-1}\, kpc^{-1}}$ but requires a lower transverse velocity for the Galactic centre than observed. This suggests systematics of $5-10\, \mathrm{km\, s^{-1}kpc^{-1}}$ dominate the uncertainty. We demonstrate using a dynamically formed bar/bulge simulation that even with the limited field of view of the VVV survey our method robustly recovers the pattern speed.
First Case Report of Human Bacteremia With Malacobacter (Arcobacter) mytili
Authors: Vasiljevic Marija , Fenwick Alexander J , Nematollahi Saman , Gundareddy Venkat P , Romagnoli Mark , Zenilman Jonathan , Carroll Karen C 
Published: July 2019

Abstract
Arcobacter spp. are commonly associated with shellfish and have been increasingly implicated in human gastrointestinal disease. We report the first case of human bacteremia with Malacobacter (previously Arcobacter) mytili acquired after exposure to Maryland crab. Arcobacter spp. should be considered in febrile illnesses when the history indicates exposure to seafood.
Effects of Intraoperative Magnetic Resonance Thermal Imaging Signal Artifact During Laser Interstitial Thermal Therapy on Thermal Damage Estimate and Postoperative Magnetic Resonance Imaging Ablative Area Concordance
Authors: Munier Sean M , Desai Akshay N , Patel Nitesh V , Danish Shabbar F 
Published: July 2019

Abstract

BACKGROUND
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive procedure that utilizes intraoperative magnetic resonance thermal imaging (MRTI) to generate a thermal damage estimate (TDE) of the ablative area. In select cases, the MRTI contains a signal artifact or defect that distorts the ablative region. No study has considered the impact of this artifact on TDE accuracy.

OBJECTIVE
To determine the effect of intraoperative MRTI signal artifact on postoperative magnetic resonance imaging (MRI)-predicted ablative area.

METHODS
All ablations were performed using the Visualase MRI-Guided Laser Ablation System (Medtronic). Patients were grouped based on whether the intraoperative MRTI contained signal artifact that distorted the ablative region. Cross-sectional area of the ablative lesion from the MRI image was measured, and the difference between intraoperative TDE and postoperative MRI cross-sectional area was calculated and compared between groups with and without intraoperative MRTI artifact.

RESULTS
A total of 91 patients undergoing MRgLITT for various surgical indications were examined. MRTI artifact was observed in 43.9% of cases overall. The mean absolute difference between TDE and the postoperative MRI cross-sectional area was 94.8 mm2 (SEM = 11.6) in the group with intraoperative MRTI artifact and 54.4 mm2 (SEM = 5.5) in the nonartifact group.

CONCLUSION
MRTI signal artifact is common during LITT. The presence of signal artifact during intraoperative MRTI results in higher variation between intraoperative TDE and postoperative MRI cross-sectional ablative area. In cases in which intraoperative MRTI artifact is observed, there may be a larger degree of variation between observed intraoperative TDE and measured postoperative MRTI ablative area.
Transforming of Ethos and Developing New Norms and Institutions
Authors: İhsanoğlu Ekmeleddİn 
Published: July 2019

Abstract
Part II discusses the transformation of education from traditional to modern through developing new institutions, introducing new cultural content. Legal identity and autonomy of the Darülfünun and its financial well-being, the evolution of modern scholarly literature and terminology, and the tradition of academic research are explained in detail. This part sheds light on an important and pioneering experiment involving both Islamic and Western cultures. It tracks the multifaceted transformation at work in İstanbul during the transition from classical to modern modes of scientific education. The Ottoman administrators themselves occupy the focus of my study, as they were the ones who set the terms for the new ethos that came to undergird the modern norms and institutions of the empire. In doing so, this study situates the establishment of the Darülfünun within the general context of Ottoman modernization.
The Revolutionary Lens
Authors: Bezzant Rhys S. 
Published: July 2019

Abstract
Part of the intriguing power of Edwards’s mentoring is the legacy he creates during and after the American Revolution. He trains his mentees to be not mere mimics but rather leaders who can reason from first principles and adapt their proclamation to the particular social context of their ministry. Edwards spawns a school of ministry known subsequently as the New Divinity, which institutionalizes Edwards’s revivalist impulses in founding Andover Seminary in Newton, Massachusetts, in 1808. Their successes in New England in local church settings and their influence on debates of the early republic are dramatic, evidenced in federalist political philosophy as well as the cause of abolition. Edwards takes traditional mentoring practices and retools them to operate in a modern and democratic world.