bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposition méthodologique en ergotoxicologie pour révéler les expositions à des produits chimiques
Authors: Galey Louis , Judon Nathalie , Jolly Caroline , Goutille Fabienne , Morelot Sarah , Albert Marion , Lhospital Olivier , Martin Patrick , Noel-Suberville Catherine , Pasquereau Pierrick , Aublet-Cuvelier Agnès , Mohammed-Brahim Brahim , Garrigou Alain 
Published: April 2019

L’ergotoxicologie a constitué depuis une quinzaine d’années un corpus conceptuel et méthodologique (Garrigou, 2011 ; Mohammed-Brahim & Garrigou, 2009) afin de contribuer à la prévention des expositions des travailleurs aux produits chimiques. Faisant suite au texte de Mohammed-Brahim et Garrigou (2009) publié dans cette revue, cet article présente les derniers développements méthodologiques en ergotoxicologie et en particulier les apports de l’usage de mesures en temps réel synchronisées à des enregistrements vidéo de situations de travail. La méthodologie fait alors appel à une technique de video exposure monitoring (VEM), dont l’objectif est de « révéler » des situations d’exposition à des produits chimiques, afin de les mettre en débat au sein des entreprises et les transformer dans une logique préventive. Cette contribution méthodologique s’appuie sur un retour d’expérience basé sur trois études de cas. Enfin, nous discutons les perspectives de cette méthodologie pour l’ergonomie afin de développer des pratiques de prévention impliquant les travailleurs, leur encadrement et les acteurs de la santé au travail.
Triple-negative breast cancer: Pattern of recurrence and survival outcomes
Authors: Chintalapani Shyny Reddy , Bala Stalin , Konatam Meher Lakshmi , Gundeti Sadashivudu , Kuruva Siva Prasad , Hui Monalisa 
Published: April 2019

Abstract
Introduction: Triple-negative breast cancer (TNBC) is a subtype of breast cancer which is defined as the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 overexpression by immunohistochemistry. As the survival data on TNBC in the Indian population are scant, this study was done to analyze the clinicopathological features and clinical outcomes of TNBC patients. Materials and Methods: Data from medical records of patients with breast cancer between 2009 and 2014 were retrieved, and patients with TNBC were identified and analyzed for demographic and clinicopathological features. Survival analyses were performed using the Kaplan–Meier method for disease-free survival (DFS) and overall survival (OS). Results: A total of 1024 breast cancer patients were registered at our institute during the study period, of which 198 were TNBCs accounting for 19.3% of all breast cancers. Median age at the diagnosis was 50 years (range, 22–78 years). Lymph nodal positivity in TNBC was associated with larger tumor size (P = 0.003) and higher tumor grade (P = 0.01). At a median follow-up of 48 months (range, 12–88), 36 (19.1%) patients had recurrence of the disease, whereas 28 (14%) patients were lost to follow-up. Lung (52.7%) was the most common site of recurrence followed by bone (25%) and brain (11.1%). Three-year DFS and OS were 63.2% and 65.6%, respectively. On univariate analysis, nodal status, size of tumor, and lymphovascular invasion were found to have a significant impact on OS and DFS. On multivariate analysis, only nodal status was significant for DFS and OS (P < 0.001 and P = 0.001, respectively). Conclusions: TNBCs have a rapid clinical course, and early recurrences are common inspite of timely medical intervention which reflects the aggressive tumor biology. This warrants further studies on intensification of chemotherapy and identification and development of targeted therapy aimed at decreasing recurrences and improving survival in this patient population.
T790M mutation and clinical outcomes with osimertinib in patients with epidermal growth factor receptor-mutant nonsmall cell lung cancer
Authors: Jaiswal Ravi , Pinninti Rakesh , Mohan MVT Krishna , Santa A , Boyella Pavan Kumar , Nambaru Lavanya , Murthy Sudha S , Chowdary K Veeriah , Rajappa Senthil 
Published: April 2019

Abstract
Introduction: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors TKIs) are highly effective in EGFR-mutant advanced lung cancer. The most common resistance mechanism to EGFR-TKI is the development of T790M mutation in Exon 20. Osimertinib, a highly selective EGFR-TKI, has been approved for use in patients who progress on the first-line TKI and harbor the T790M mutation. Objective: The primary objective is to prospectively study the incidence of T790M mutation in patients who progress on the first-line EGFR-TKI. Secondary objectives include clinical characteristics that predict for T790M mutation and outcomes with osimertinib. Materials and Methods: This single-center, prospective observational study included 90 patients who progressed on first-line EGFR TKI. All patients had DNA extracted from tissue re-biopsy or plasma circulating tumor DNA (re-biopsy was not feasible or inadequate). T790M mutation was detected using amplification refractory mutation system-polymerase chain reaction, and patients harboring T790M mutation were started on osimertinib (80 mg once daily) until progression or unacceptable side effects. Results: At progression, T790M mutation was detected in 47/90 patients (52.2%). On binary logistic regression model analysis, variables that were independently predictive of the development of T790M were younger age (odds ratio [OR] 4.3, 95% confidence interval [CI] 1.14–16.6, P = 0.031); nonerlotinib TKI use (OR 8.3, 95% CI 1.24–55.8, P = 0.029); and pure adenocarcinoma histology (OR 6.2, 95% CI 1.60–24.7, P = 0.008). Forty-six patients were started on osimertinib. The overall response rate and median progression-free survival were 65.21% and 12.45 months (standard deviation [SD] 1.03, 95% CI 10.41–14.48), respectively. Osimertinib was well tolerated with most toxicities being Grade 1 and 2 diarrhea and skin rash. Conclusions: In our prospective cohort, half of all patients had a T790M mutation at progression on the first-line EGFR TKI. Tissue biopsy is feasible in the majority of patients. Clinical outcomes with osimertinib were consistent with those reported.
Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer
Authors: Ribeiro André Marcondes Braga , Lima Eduardo Nóbrega Pereira , Rocha Maurìcio Murce 
Published: April 2019

AbstractPositron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen.68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.
Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel?
Authors: Rahbar Kambiz , Afshar-Oromieh Ali , Seifert Robert , Wagner Stefan , Schäfers Michael , Bögemann Martin , Weckesser Matthias 
Published: April 2019

AbstractRecently introduced fluorine-18 prostate-specific membrane antigen-1007 (18F-PSMA-1007) for imaging prostate cancer has an intense physiologic liver uptake and biliary excretion. The aim of the present study was to evaluate the effect of different dietary conditions on this physiological uptake. Forty consecutive prostate cancer patients were scanned with 18F-PSMA-1007 positron emission tomography/computed tomography at different dietary conditions. In addition to a blinded read scoring, tracer uptake intensities (standardized uptake values [SUVs]) were measured in the liver and small bowel. There was no significant difference in liver and small-bowel uptake between different patient groups. Wilcoxon signed-rank tests revealed no significant difference of the median mean SUV of the liver or maximum SUV of the horizontal part of the duodenum between different dietary conditions groups. A dietary preparation of patients by fasting or the attempt to clear liver activity by high caloric drinks does not have a significant effect on tracer uptake in the liver or in the small bowel.
Genetic variations in the sheep &lt;i&gt;SIRT7&lt;/i&gt; gene and their correlation with body size traits
Authors: Xu Hongwei , Zhang Xiaoyu , Zang Rongxin , Cai Yong , Cao Xin , Yang Jutian , Li Jie , Lan Xianyong , Wu Jianping 
Published: April 2019

Abstract. As a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase
and ADP ribosyl transferase, the silent information regulator 7 (Sirtuin 7,
SIRT7) plays a crucial role in regulating the differentiation of adipocytes
and myoblasts, lipid metabolism, glucose metabolism, and cellular growth in
mammals. It has been hypothesized that SIRT7 affects growth traits in animals;
therefore, in this study, the potential insertion/deletion (indel) of genetic variations within
the ovine SIRT7 gene and their correlation with sheep growth traits
were explored. A total of 709 individuals from five Chinese
and Mongolian sheep breeds were analyzed. Two novel indel loci of the sheep
SIRT7 gene were detected and were named 5′ promoter
region-insertion-7 bp (5′ promoter region-7 bp) and 3′
UTR-insertion-17 bp (3′ UTR-17 bp), respectively. In all of the sheep breeds,
frequencies of the 5′ promoter region-7 bp mutation were low, whereas
mutations of 3′ UTR-17 bp were high in Tong sheep and Lanzhou fat-tail
sheep (LFTS). Furthermore, both indel polymorphisms had significant
associations with different growth characteristics (P<0.05). Among
these associations, the 3′ UTR-17 bp was highly correlated with rump width
in small-tail Han sheep (STHS, rams; P<0.01), and
individuals with the ID genotype had better chest depth values than those
with the II genotype. In this paper, two novel indels within the sheep
SIRT7 gene were identified, and genetic diversity and its
effects on body size traits were explored. These findings will potentially provide
useful DNA markers for the improvement of economic traits in sheep genetic breeding.
Exercise-induced changes in skin temperature and blood parameters in horses
Authors: Soroko Maria , Śpitalniak-Bajerska Kinga , Zaborski Daniel , Poźniak Błażej , Dudek Krzysztof , Janczarek Iwona 
Published: April 2019

Abstract. The aim of the study was to assess the effects of
training on haematological and biochemical blood parameters as well as on
the changes in body surface temperature in horses. In order to identify the
predictive value of surface temperature measurements as a marker of animal's
performance, their correlations with blood parameters were investigated. The
study was carried out on nine horses divided into two groups: routinely ridden
and never ridden. Infrared thermography was used to assess surface
temperature changes before (BT) and just after training (JAT) on a
treadmill. Seven regions of interest (ROIs) located on the neck, shoulder,
elbow, back, chest, gluteus and quarter were analysed. The blood samples
were taken BT, JAT and 30 min after training (30AT). Haematological
parameters including white blood cells, lymphocytes (LYMs), monocytes (MONOs),
granulocytes (GRAs), eosinophils (EOSs), haematocrit (HCT) and platelets (PLTs)
as well as biochemical parameters such as glucose (GLUC), urea,
Na+, K+ and Ca2+, and creatine phosphokinase (CPK) were
analysed. Our results indicated a significant increase in surface
temperature JAT (p=0.043) in the neck, shoulder, elbow, gluteus and
quarter in routinely ridden horses. Significant changes in EOS (p=0.046)
and HCT (p=0.043) in the case of the never-ridden and routinely ridden group,
respectively, were found between the times of blood collection. In addition,
there was a significant effect of the horse group and the time of blood
collection on the CPK activity (p=0.025 to p=0.045) and urea
concentrations (p=0.027 to p=0.045). In the routinely ridden horses,
there were significant correlations between the changes in MONO
(ρ=0.40), GRA (ρ=-0.40), PLT (ρ=-0.77), HCT (ρ=-0.36), GLUC
(ρ=0.56) and urea (ρ=0.56) and the total ROI temperature changes.
Moreover, significant correlations between the changes in MONO
(ρ=-0.86), EOS (ρ=-0.65), GLUC (ρ=0.85), urea (ρ=0.85),
Na+ (ρ=0.59) and K+ (ρ=-0.85) and the total ROI
temperature changes were found in never-ridden horses. Different changes in
body surface temperature and blood parameters in routinely ridden and
never-ridden horses could be associated with different conditioning and
performance. A significantly higher surface temperature in routinely ridden
horses, as well as the dynamics of changes in HCT, CPK and urea after
training indicate better performance of these horses. Significant
correlations between MONO, GLUC, and urea and a total ROI surface temperature
as well as a negative correlation between MONO and the total ROI temperature
in never-ridden horses indicated poor performance.
Fitting a stochastic fire spread model to data
Authors: Wang X. Joey , Thompson John R. J. , Braun W. John , Woolford Douglas G. 
Published: April 2019

Abstract. As the climate changes, it is important to understand the effects on the
environment. Changes in wildland fire risk are an important example. A
stochastic lattice-based wildland fire spread model was proposed by Boychuk
et al. (2007), followed by a more realistic variant (Braun and Woolford,
2013). Fitting such a model to data from remotely sensed images could be used
to provide accurate fire spread risk maps, but an intermediate step on the
path to that goal is to verify the model on data collected under
experimentally controlled conditions. This paper presents the analysis of
data from small-scale experimental fires that were digitally video-recorded.
Data extraction and processing methods and issues are discussed, along with
an estimation methodology that uses differential equations for the moments of
certain statistics that can be derived from a sequential set of photographs
from a fire. The interaction between model variability and raster resolution
is discussed and an argument for partial validation of the model is provided.
Visual diagnostics show that the model is doing well at capturing the
distribution of key statistics recorded during observed fires.
Ocean carbon and nitrogen isotopes in CSIRO Mk3L-COAL version 1.0: a tool for palaeoceanographic research
Authors: Buchanan Pearse J. , Matear Richard J. , Chase Zanna , Phipps Steven J. , Bindoff Nathan L. 
Published: April 2019

Abstract. The isotopes of carbon (δ13C) and nitrogen
(δ15N) are commonly used proxies for understanding the ocean.
When used in tandem, they provide powerful insight into physical and
biogeochemical processes. Here, we detail the implementation of
δ13C and δ15N in the ocean component of an
Earth system model. We evaluate our simulated δ13C and
δ15N against contemporary measurements, place the model's
performance alongside other isotope-enabled models and document the response
of δ13C and δ15N to changes in ecosystem
functioning. The model combines the Commonwealth Scientific and Industrial
Research Organisation Mark 3L (CSIRO Mk3L) climate system model with the
Carbon of the Ocean, Atmosphere and Land (COAL) biogeochemical model. The
oceanic component of CSIRO Mk3L-COAL has a resolution of 1.6∘
latitude × 2.8∘ longitude and resolves multimillennial
timescales, running at a rate of ∼400 years per day. We show that this
coarse-resolution, computationally efficient model adequately reproduces
water column and core-top δ13C and δ15N
measurements, making it a useful tool for palaeoceanographic research.
Changes to ecosystem function involve varying phytoplankton stoichiometry,
varying CaCO3 production based on calcite saturation state and
varying N2 fixation via iron limitation. We find that large changes
in CaCO3 production have little effect on δ13C and
δ15N, while changes in N2 fixation and phytoplankton
stoichiometry have substantial and complex effects. Interpretations of
palaeoceanographic records are therefore open to multiple lines of
interpretation where multiple processes imprint on the isotopic signature,
such as in the tropics, where denitrification, N2 fixation and
nutrient utilisation influence δ15N. Hence, there is
significant scope for isotope-enabled models to provide more robust
interpretations of the proxy records.
Impact of prechemotherapy preparation on knowledge, coping attitude and satisfaction among newly diagnosed patients with cancer
Authors: Aboalizm Samira E. , El-Sayad Hanaa E. 
Published: April 2019

Objective: Cancer’s patients receiving chemotherapy need information about the treatments and self-care that must practice in order to prevent serious complications. Purpose of the study: To determine the impact of prechemotherapy preparation on knowledge, coping attitude and satisfaction among newly diagnosed patients with cancer.Methods: Quasi experimental research design was used. The study was conducted at outpatient’s chemotherapy clinic and at word of the Oncology Menoufia University Hospital, Shebin El-Kom, Egypt. A convenience sample of 100 adult patients of both sexes who were diagnosed with cancer in the Oncology outpatient clinic and would receive first time chemotherapy treatment were enrolled in this study. Three tools were used. Tool I: Chemotherapy Patients needs assessment: structured interviewing scheduled questionnaire: The tool consisted of the following 2 parts. Part 1: Sociodemographic and clinical data, Part II: Pre Chemotherapy Knowledge Assessment Sheet. Tool II: 16 attributes of cancer therapy satisfaction questionnaire (CTSQ). Tool III: Cancer Coping Questionnaire (CCQ) 21 Items Versions.Results: The study group had better knowledge, coping and satisfaction post intervention than control group. There was statistically considerable differences between study and control group concerning the mean total score of satisfaction and coping (p value < .001). There were significant positive correlation total score of cancer coping and mean score of cancer therapy satisfaction p value < .001.Conclusions: Prechemotherapy preparation to cancer patients improved patient’s knowledge, satisfaction and coping. Recommendation: Prechemotherapy education should be considered a part of routine nursing care performed for all newly diagnosed patients with cancer who would receive chemotherapy for first time.
Evaluation of the socially evaluated cold-pressor group test (SECPT-G) in the general population
Authors: Becker Linda , Schade Ursula , Rohleder Nicolas 
Published: April 2019

Background. In stress research, economic instruments for introducing acute stress responses are needed. In this study, we investigated whether the socially evaluated cold-pressor group test (SECPT-G) induces salivary alpha-amylase and/or cortisol responses in the general population and whether it is associated with anthropometric, experimental, and lifestyle factors.
Methods. A total of 91 participants was recruited. Salivary cortisol and alpha-amylase levels were assessed prior (t0), immediately after (t1), and ten minutes after the SECPT-G (t2).
Results. A strong cortisol increase was found immediately after the SECPT-G, which further increased between t1 and t2. This was independent of most of the control variables. However, men showed stronger cortisol increases than women. No sAA responses were found at all.
Conclusions. We conclude that the SECPT-G is a good means of an acute stress test when cortisol – but not necessarily sAA – responses are intended.
Single‐Stimulus‐Induced Modulation of Multiple Optical Properties
Authors: Li Hai , Li Chaoran , Sun Wei , Wang Yuzhu , Hua Wenqiang , Liu Jingjing , Zhang Shumin , Chen Zhijie , Wang Shenghua , Wu Zhiyi , Zhu Qishan , Tang Rujun , Yu Jia , He Le , Ozin Geoffrey A. , Zhang Xiaohong 
Published: April 2019

AbstractStimuli‐responsive smart optical materials hold great promise for applications in active optics, display, sensing, energy conversion, military camouflage, and artificial intelligence. However, their applications are greatly restricted by the difficulty of tuning different optical properties within the same material, especially by a single stimulus. Here, magnetic modulations of multiple optical properties are demonstrated in a crystalline colloidal array (CCA) of magnetic nanorods. Small‐angle X‐ray scattering studies reveal that these nanorods form an unusual monoclinic crystal in concentrated suspensions. The CCA exhibits optical anisotropy in the form of a photonic bandgap and birefringence, thus enabling magnetic tuning of the structural color and transmittance at a rate of 50 Hz. As a proof‐of‐concept, it is further demonstrated that the fabrication of a multifunctional device for display, anticounterfeiting, and smart‐window applications based on this multiple magneto‐optical effect. The study not only provides a new model system for understanding colloidal assembly, but also opens up opportunities for new applications of smart optical materials for various purposes.
Phenothiazine‐Based Organic Catholyte for High‐Capacity and Long‐Life Aqueous Redox Flow Batteries
Authors: Zhang Changkun , Niu Zhihui , Peng Sangshan , Ding Yu , Zhang Leyuan , Guo Xuelin , Zhao Yu , Yu Guihua 
Published: April 2019

AbstractRedox‐active organic materials have been considered as one of the most promising “green” candidates for aqueous redox flow batteries (RFBs) due to the natural abundance, structural diversity, and high tailorability. However, many reported organic molecules are employed in the anode, and molecules with highly reversible capacity for the cathode are limited. Here, a class of heteroaromatic phenothiazine derivatives is reported as promising positive materials for aqueous RFBs. Among these derivatives, methylene blue (MB) possesses high reversibility with extremely fast redox kinetics (electron‐transfer rate constant of 0.32 cm s−1), excellent stability in both neutral and reduced states, and high solubility in an acetic‐acid–water solvent, leading to a high reversible capacity of ≈71 Ah L−1. Symmetric RFBs based on MB electrolyte demonstrate remarkable stability with no capacity decay over 1200 cycles. Even concentrated MB catholyte (1.5 m) is still able to deliver stable capacity over hundreds of cycles in a full cell system. The impressive cell performance validates the practicability of MB for large‐scale electrical energy storage.