bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview
Authors: Thakur Sourav , Singh Bhupendra , Mishra Vijay , Yadav Nishika , Giri Namita , Sharma Pardeep , Saini Ankit , Garg Lavi K. 
Published: March 2019

Background:
Asthma is a common ailment with a larger circadian difference. Nocturnal
Asthma (NA) is an inconstant exacerbation of asthmatic condition related to the rise in warning sign
during the night time and there is a need for its treatment addressing air route alertness and decline in
lung functions. These symptoms are linked to sleep or known as circadian events. Chronotherapeutics
is a management system based on an in-vivo drug accessibility programmed to check the rhythms of
ailment in a direction to improve the therapeutic outcomes by suppressing the side effects. This review
aims to provide an overview of NA, chronotherapeutics for the treatment of NA, bilayer tablets, and
advanced techniques involved in the fabrication of bilayer tablets. The review also discusses some of
the related patents.

Methods:
Relevant literature about the latest developments and updated information related to NA,
chronotherapeutics and bilayer tablets has been very widely searched on different biomedical literature
programs such as Google, Web of Science, PubMed portals, etc. Bilayer tablet mediated chronotherapy
has gained significant attention and consideration as it is developed and fabricated based on the body’s
circadian rhythm. Bilayer tablets can deliver the bioactive compounds at an appropriate time, place as
well as amount and site.

Results:
Available literature advocated that the bilayer matrix tablet containing a single drug in the
sustained release film and fast releasing film, may be beneficial for the chronic diseases like asthma,
migraine, diabetes, hypertension and inflammation which usually require immediate as well as
maintained therapeutic effect.

Conclusion:
The application of nanotechnology in the arena of medicine will transform the diagnosis
and treatment strategies of a wide range of diseases in the upcoming years. The findings of this review
confirm the importance of bilayer tablet based chronotherapy in nocturnal asthma.
Gamma Emitters in Pancreatic Endocrine Tumors Imaging in the PET Era: Is there a Clinical Space for 99mTc-peptides?
Authors: Briganti Vittorio , Cuccurullo Vincenzo , Di Stasio Giuseppe Danilo , Mansi Luigi 
Published: March 2019

Background:Pancreatic Neuroendocrine Tumors (PNETs) are rare neoplasms, sporadic or familial, even being part of a syndrome. Their diagnosis is based on symptoms, hormonal disorders or may be fortuitous. The role of Nuclear Medicine is important, mainly because of the possibility of a theranostic strategy. This approach is allowed by the availability of biochemical agents, which may be labeled with radionuclides suitable for diagnostic or therapeutic purposes, showing almost identical pharmacokinetics. The major role for radiopharmaceuticals is connected with radiolabeled Somatostatin Analogues (SSA), since somatostatin receptors are highly expressed on some of the neoplastic cell types.Discussion:Nowadays, in the category of radiolabeled SSA, although 111In-pentetreotide, firstly commercially proposed, is still used, the best choice for diagnosis is related to the so called DOTAPET radiotracers labeled with 68-Gallium (Ga), such as 68Ga-DOTATATE, 68Ga-DOTANOC, and 68Ga-DOTATOC. More recently, labeling with 64-Copper (Cu) (64Cu-DOTATATE) has also been proposed. In this review, we discuss the clinical interest of a SAA (Tektrotyd©) radiolabeled with 99mTc, a gamma emitter with better characteristics, with respect to 111Indium, radiolabeling Octreoscan ©. By comparing both pharmacokinetics and pharmacodynamics of Octreoscan©, Tektrotyd© and PET DOTA-peptides, on the basis of literature data and of our own experience, we tried to highlight these topics to stimulate further studies, individuating actual clinical indications for all of these radiotracers.Conclusion:In our opinion, Tektrotyd© could already find its applicative dimension in the daily practice of NETs, either pancreatic or not, at least in centers without a PET/CT or a 68Ga generator. Because of wider availability, a lower cost, and a longer decay, compared with respect to peptides labeled with 68Ga, it could be also proposed, in a theranostic context, for a dosimetry evaluation of patients undergoing Peptide Receptor Radionuclide Therapy (PRRT), and for non-oncologic indications of radiolabelled SSA. In this direction, and for a more rigorous cost/effective evaluation, more precisely individuating its clinical role, further studies are needed.
Calculation of Thermal Radiation Level During a Pool Fire Caused by Leakage of Kerosene from Tanker Wagon at Railway Crossings
Authors: Mišić Nikola , Zigar Darko , Božilov Aca , Pešić Dušica 
Published: March 2019

Abstract
The spillages due to collisions related incidents involving the wagon tankers, which carrying hazardous materials (hazmat), can be followed by fires or explosions, presents a severe threat to the safety of residents and nearby buildings. In this study, ALOHA and PHAST was used to evaluate the level of thermal radiation at different distances from the place of accident. Discussed scenario analyze a leakage of kerosene from a tanker wagon, from different opening diameters, where is formed a pool fire. As an assumption for location of possible accident, parts of the railway where it can be expected a large number of people and vehicles were taken. For study area was chosen city of Niš, Serbia.
EFFECT OF ERGONOMIC GYMNASTIC ON BLOOD PRESSURE AND LIPID PROFILE HYPERTENSION PATIENT AT SUMBER AGUNG VILLAGE, JATIREJO DISTRICT, MOJOKERTO CITY, INDONESIA
Authors: Soemah Eka Nur , Hariyanto Agus , Akbar Amar 
Published: March 2019

Background : Hypertension is the most common disease found in the community. It does not only degrade the quality of life, but it can be life-threatening. Hypertension is known as heterogeneous group of disease because it can affect anyone from different age groups and various economic classes. There are two therapies for hypertension ie pharmacology and nonpharmacology. One of non-pharmacology therapy is doing ergonomic gymnastics. The purpose of this study is to see the effect of ergonomic gymnastics on blood pressure in people with hypertension in Sumber Agung Village, Jatirejo Sub-district, Mojokerto Regency.
Method : This research method used one group pre test - post test design with control group. Sampling technique used was simple random sampling, from 80-person population of hypertension patient in Sumber Agung Village Jatirejo Sub-district Mojokerto Regency and become sample number 20 respondents in treatment group, and 20 respondents in control group according to criteria. Data collection using interval scale blood presure and total cholesterol. Analysis using statistical test Paired T test and Independent T-test SPSS 17.
Result : From the analysis we got result p value 0,00 <0,05 it indacted that means of blood presure and lipid profile before ergonomic gymnastic and after ergonomic gymnastic shown significat value, it means that ergonomic gymnastic was very effective for blood pressure and lipid profile (total cholesterol).
Discussion : Ergonomic gymnastics is one of effective therapy, easy to do and useful. Because ergonomic gymnastics can make the body become relaxed and blood vessels become vasodilated so that the blood flow and oxygen supply becomes smooth and it get impact in lipid profile .
keywords : Aergonomic Gymnastic, Blood Pressure, Lipid Profile, Hipertension.
THE CORRELATION OF PSYCHOLOGICAL COUNSELING IN PKPR WITH THE ABILITY TO PROBLEM SOLVING ADOLESCENTS AGED 13-15 YEARS AT LOWER SECONDARY SCHOOL STATE 1 PURI MOJOKERTO
Authors: Wahyuningsih Binarti Dwi , Wahyuni Lutfi Wahyuni 
Published: March 2019

THE CORRELATION OF PSYCHOLOGICAL COUNSELING IN PKPR WITH THE ABILITY TO PROBLEM SOLVING ADOLESCENTS AGED 13-15 YEARS AT LOWER SECONDARY SCHOOL STATE 1 PURI MOJOKERTO
By: Binarti Dwi,Lutfi Wahyuni,

Abctract : This study aims to analyze correlation between the role of adolescence care services (PKPR) particular program as psychological counseling to problem solving capabilities in adolescent aged 13-15 years at lower secondary school state 1 puri Mojokerto. This study used is analytic with cross-sectional. A simple of 52 people were taken by cluster random sampling. Protap monitoring data collection using standard PKPR 3 adolescence, especcially psychological counseling program and questionnaire problem solving abilities. Spearman rho test showed that p (0,000) < Î± (0,05) so, H0 is rejected it means there is correlation of psychological counseling in pkpr with the ability to problem solving adolescents aged 13-15 years at lower secondary school state 1 puri Mojokerto. Whith valve r-0,474 which shows correlation moderat. To improve quality of Psychological counseling services in PKPR expected to help adolescent choose alternative solotions to problems and improve the ability of problem solving in adolescent.
PENGAMBILAN KEPUTUSAN HUTANG PADA USAHA KECIL DAN MENENGAH (UKM) DI PULAU LOMBOK: SUATU PERSPEKTIF BEHAVIORAL FINANCE
Authors: Hidayati Siti Aisyah , Suryani Embun , Muhdin M 
Published: March 2019

The purpose of this study is to find out what factors determine decision making of debt and what are the most dominant factors in decision making of debt for SMEs on the island of Lombok. This research is an explanatory research with quantitative approach. The population is all SMEs located in Lombok island. The sample is selected by Non probability sampling technique with a judgment sampling method where the SMEs that selected as samples are SMEs in handicraft industry of pottery and already exporting the products. Of the existing population, there are 25 (twenty five) SMEs that can be sampled. Respondents in this study are managers who also the owner of the SMEs. Data was collected using questionnaire. To achieve the research objectives, the data obtained will be processed according to needs using Factor Analysis.The results of this study indicate there are three groups of factors that determine decision making of debt, namely the First Factor Group consists of: Variable Excessive Optimism, Variable Overconfidence, Variable Confirmation Bias and Variable Aversion to sure loss. This factor is named Factor Overconfidence. The Second Factor Group consisted of Representativeness Variables, Avaibility Variables and Anchoring and Adjustment Variables. This factor is named the Avaibility Factor. The third factor group consists of Affect Variables and Aversion Loss Variables. This factor is named the Factor of Loss Aversion. The most dominant factor in determining debt decision making for SMEs in Lombok Island is the Overconfidence factor group consisting of Variable Excessive Optimism, Variable Overconfidence, Variable Confirmation Bias and Variable Aversion to sure loss .Keyword:Behavioral finance, decision making of debt, SMEs
Effects of Zinc Borate on the Flame Retardancy Performance of Aluminum Diethylphosphinate in Polyamide-6 and its Composites
Authors: Polat O. , Kaynak C. 
Published: March 2019

Abstract
In this study, the flame retardancy contribution of zinc borate when used together with a traditional flame retardant (aluminum diethylphosphinate compound) was investigated for neat polyamide-6 and for 15 wt% short glass fiber reinforced composite. Melt mixing with twin-screw extrusion was the compounding method while injection and compression molding were the shaping methods of specimens. Three different flammability tests (limiting oxygen index, UL-94 vertical burning, mass loss calorimetry) indicated that many flame retardancy parameters could be improved significantly by replacing a certain amount of aluminum diethylphosphinate with zinc borate. For example, using aluminum diethylphosphinate alone resulted in only 32 % suppression in the value of the peak heat release rate for neat polyamide-6, while it was 82 % (more than two-fold) when used together with zinc borate. It was revealed by evolved gas analyses, char analyses, x-ray diffraction and thermogravimetry that the main contribution of zinc borate to aluminum diethylphosphinate was in terms of a barrier mechanism via formation of additional boron phosphate inorganic content in the barrier layer.
MEKAN, MÜZİK VE KİMLİK İLİŞKİSİ EKSENİNDE ÇAMDİBİ MÜZİSYEN KIRAATHANESİ VE “AREFE ÇALGISI” UYGULAMASI
Authors: DEVRİM KÜÇÜKEBE Hande 
Published: March 2019

İnsanın çeşitli sosyal aktiviteleri gerçekleştirmek amacıyla kendi eliyle yarattığı,
coğrafi sınırlarla belirlenmiş mekanlar, yüklendikleri sembolik özellikler aracılığıyla
kültürel kimliği yaratma, yeniden yaratma ya da dönüştürme gücüne sahiptirler.
Mekanın müzik aracılığı ile kültürel kimliği inşa etme/dönüştürme gücünün
görüldüğü/mekan-müzik-kimlik ilişkisinin irdelenebileceği örnek olaylar ise küresel,
yerel ve bölgesel, kentsel, hatta sanal düzeyde mekanlarda
gerçekleşebilmektedirler. Bu makalede mekan kavramı geniş ölçekte İzmir kenti,
daha dar ölçekte ise Çamdibi semti ve ona bağlı bir kent mekanı olan Çamdibi
Müzisyen Kıraathanesi ile sınırlandırılmıştır. Makedonya göçmenleri, İzmir’de
yerleştikleri başlıca semtlerden biri olan Çamdibi’nde evlerini ve mahallelerini inşa
ederken yeni koşullar altında kültürel kimliklerini de yeniden kurgulamışlardır. Bu
yeni kimliksel yapı içerisinde müzik, onları kozmopolit İzmir kentindeki diğer
kültürel gruplardan farklı kılan ve grup kimliğini yaratan unsurlardan biri olmuştur.
Çamdibi Müzisyen Kıraathanesi ise “Çamdibili olma” ve “müzik” anahtar
kelimelerinin “Makedonya göçmeni olmak” ile eş değer olduğu bu anlam dünyası
içerisinde var edilmiş ve göçmen müzisyenlerin Ramazan bayramını karşılamak
üzere düzenledikleri “Arefe Çalgısı” uygulamasının doğuşuna vesile olmuştur.
Makale, söz konusu mekanın ve uygulamanın göçmen kimliği ve müzisyen
kimliğinin oluşum/dönüşüm sürecindeki rolünü ele almaktadır.&nbsp;
Evaluating continuous measurement: Data quality in the Bronx test site of the American community survey
Authors: Salvo Joseph J. , Lobo Arun Peter , Love Susan P. 
Published: March 2019

The American Community Survey (ACS) is a continuous measurement survey program designed to replace the census long form sample. While the census sample provides detailed socioeconomic data once a decade, the ACS will provide these data annually using a questionnaire that largely mirrors the census long form. This paper examines operational data in Bronx County, one of 36 ACS test counties, and finds the ACS superior to the census on two important measures of data quality. First, applying the minimal data requirement for inclusion of a long form in the census sample, ACS questionnaires were significantly more likely than the long forms to meet this threshold. Second, the level of nonresponse to items on the ACS was often one-half the census level. The ACS and census have sharply divergent goals and operational methods that affect data quality. The primary objective of the census is a population count for reapportionment and redistricting; collecting long form information is a secondary goal. In contrast, the primary objective of the ACS is to estimate the characteristics of an area based on answers to all items on the survey. Operationally, the census follows up every nonresponding household, using a pool of minimally trained, temporary workers. In comparison, the ACS follows up only one-in-three nonresponding households, using a permanent cadre of professional interviewers. This results in superior nonresponse follow-up in the ACS, with lower levels of non-sampling error, even in more difficult-to-enumerate high poverty areas of the Bronx. The ACS is to be fully implemented in July 2004, pending Congressional funding. With detailed socioeconomic data available annually from the ACS, the 2010 census would then be able to focus primarily on a population headcount. The paper concludes by discussing operational aspects of the ACS that must be improved, including increasing its visibility, for the survey to be accepted as an integral part of the nation's data collection system.
A new monthly index of the Texas business cycle
Authors: Phillips Keith R. 
Published: March 2019

The timing, length and severity of economic recessions and expansions in a state are important to businesses seeking to set up operations or expand in those areas. Given a limited amount of data at the state level and their sometimes inconsistent movements, it is not straightforward to define a state business cycle. In this article I attempt to measure the Texas business cycle using a technique developed by Stock and Watson that statistically estimates the underlying comovement in broad indicators of the state's economy. The new Texas Coincident Index (TCI) is constructed with the Texas unemployment rate, a quarterly Real Gross State Product measure due to Berger and Phillips, and a nonfarm employment series that is benchmarked quarterly and is seasonally adjusted using the two-step approach described in Berger and Phillips. Use of these components and the Kalman filter, which smoothes across variables as well as over time, results in an index which is much smoother and gives clearer signals of turning points than the old TCI produced by Phillips. The new TCI exhibits cyclical patterns that are highly correlated with those of employment and RGSP, and matches well with recessions and expansions that were independently identified.
Perubahan Teknologi dan Efisiensi pada Organisasi Pengelola Zakat di Indonesia
Authors: Rusydiana Aam Slamet 
Published: March 2019

Zakah institution is the intermediary organizations based on social. Although based on social activities, but the management is still needs to uphold professional, accountability and transparency principles. This study attempts to analyze the productivity level of zakat organization in Indonesia, both in terms of changes of its efficiency, and also its technological. There are two things that are calculated in Malmquist index measurement that is catch-up effect and frontier shift effect. The catch-up effect measures the rate of change in relative efficiency from period 1 to period 2. Meanwhile the frontier shift effect measures the rate of technological change that is a combination of input and output from period 1 to period 2. The frontier shift effect is often called an innovation effect. Findings from the results of the productivity index analysis are very interesting. In general, there has been an increase in the level of productivity of zakat institutions in Indonesia in the period 2011 to 2016. The increase in productivity growth (1.116) of zakat institutions in Indonesia is generally caused by technological change (1.137) instead of changes in efficiency (0.982). Thus the service of zakat institutions is needed which is more innovative in relation to the development of technology in the future.
Aplicabilidad del derecho procesal interamericano a un país en transición de paz.
Authors: Duque Sierra Dudley , Rivas Mosquera Luis Alberto , Mena Romaña Andrés Francisco 
Published: March 2019

El derecho evoluciona a la par con la sociedad, principio universal de justica; los gobiernos adoptan sistemas y prácticas de aplicación del derecho, como lo hace la justicia interamericana que vela para que se aplique en lo regional lo pactado, en especial la protección y promoción de DDHH; la norma de derecho sustancial para su efectividad requiere de un mecanismo que pueda lograr desentrañar el espíritu de las mismas permitiendo así que todas sus prerrogativas puedan ser materializadas garantizando justicia, verdad, reparación y no repetición. La investigación se realizó utilizando el método deductivo directo; se partió conocimiento lato de la normativa existente y su contraste con el sistema internacional definido para la garantía y protección de los Derechos Humanos.
Formalidades del matrimonio en el código general del proceso
Authors: Morales Acacio Alcides 
Published: March 2019

En esta investigación se apreciarán las distintas normativas existentes para la celebración del matrimonio, a partir de la entrada en vigencia del Código General del Proceso, en las cuales quedaron derogados algunos artículos del Código de Procedimiento Civil. Por ello, es perentorio realizar un análisis holístico y jurídico del contrato sinalagmático del matrimonio en el nuevo Código General del Proceso para verificar su validez jurídica, con el propósito de identificar las nuevas formalidades existentes y su apoyo legal. Se encontrarán en la investigación todos los cambios introducidos por el legislador, encaminados a brindar eficacia procesal a este contrato.
Corrupción en Colombia : el lado oscuro de un país en desarrollo.
Authors: Correa Fernández Marlon De Jesús 
Published: March 2019

Según estudios de organismos nacionales e internacionales, se evidencia altos niveles de corrupción en el país, a pesar de adoptar diferentes mecanismos legales. Por eso, se buscó delimitar las raíces de la corrupción en Colombia; la legislación nacionales con mayor corrupción; y las posibles soluciones. Se concluyó, la necesidad de adoptar medidas coercitivas, desarrollar una cultura desde la educación, para formar un ciudadano cumplidor de la ley en beneficio su comunidad.