bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Dose 4-Factor Prothrombin Complex Concentrate for Warfarin-Induced Intracranial Hemorrhage
Authors: Merchan Cristian , Ahuja Tania , Raco Veronica , Lewis Ariane 
Published: May 2019

Background and Purpose: The ideal dosing regimen of 4-factor prothrombin complex concentrate (4FPCC) after warfarin-induced intracranial hemorrhage (WICH) remains unclear. We sought to compare the safety and efficacy of the 4FPCC package insert dosing strategy (standard dose [SD]) with our institutional guideline for high-dose (HD) 4FPCC for patients with WICH. Methods: We compared the percentage of SD and HD patients who achieved an international normalized ratio (INR) ≤1.3 at a single institution between January 2014 and July 2017. Additionally, we assessed hematoma expansion, recurrence of INR > 1.3, and occurrence of thrombotic events within 7 days of 4FPCC administration. Results: Of 48 patients with WICH, 30 received SD and 18 received HD. The median baseline INR was 2.5 (2.0-3.8) for SD patients and 3.3 (2.5-5) for HD patients ( P = .147). Successful achievement of an INR ≤ 1.3 after the initial 4FPCC dose was obtained in 70% of patients in the SD group and 94% of patients in the HD group ( P = .124). A higher percentage of patients in the SD group had an INR > 1.3 at some point after admission (30% vs 6%; P = .053). There was a trend toward more hematoma expansion in the SD group, but this was not statistically significant (17% in the SD group vs 0% in HD group; P = .056). There were 2 thrombotic events: one deep vein thrombosis in each group ( P = .243). Conclusions: High-dose 4FPCC appears to be more effective at lowering INR and preventing bleed expansion in patients with WICH, while maintaining a similar safety profile.
The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension
Authors: Pagonas Nikolaos , Vlatsas Stergios , Bauer Frederic , Seibert Felix S , Sasko B , Buschmann I , Ritter O , Kelesidis Theodoros , Westhoff Timm H 
Published: May 2019

Background Exercise training increases high-density lipoprotein (HDL) cholesterol, but its effect on HDL function is unclear. In hypertensives, exercise improves endothelial dysfunction, which is related to HDL function. In the present study, we assess for the first time the effects of different exercise modalities on two cell-free assays of HDL function. Design The study was conducted as a prospective randomized controlled trial in 75 hypertensive patients. Methods Patients were randomized in three groups: (a) handgrip isometric training five times weekly; (b) placebo-handgrip; and (c) aerobic exercise training at least three times per week. HDL function was assessed in serum samples at baseline and after 12 weeks of training by two independent assays that determine the proinflammatory phenotype (haptoglobin content) of a specific amount of HDL (Haptoglobin-HDL [HPHDL]) and oxidized HDL (HDLox) as a measure of reduced antioxidant function of HDL. HDL function measures were normalized by the measures of a pooled control of sera from healthy participants and by HDL-C levels (normalized ratio, no units). Results Aerobic exercise led to significant reduction of the HDLox from 0.99 ± 0.27 to 0.90 ± 0.29 (no units, p = 0.03). The HPHDL did not change in any training group. Changes of HDLox correlated with reduction of the systolic blood pressure only after aerobic exercise ( R = 0.64, p = 0.03). Conclusions Aerobic but not isometric exercise improves the antioxidant function of HDL in patients with hypertension. This improvement correlates positively with reductions of blood pressure.
Improving cardiac rehabilitation uptake: Potential health gains by socioeconomic status
Authors: Hinde Sebastian , Bojke Laura , Harrison Alexander , Doherty Patrick 
Published: May 2019

Background Globally, cardiac rehabilitation (CR) is recommended as soon as possible after admission from an acute myocardial infarction (MI) or revascularisation. However, uptake is consistently poor internationally, ranging from 10% to 60%. The low level of uptake is compounded by variation across different socioeconomic groups. Policy recommendations continue to focus on increasing uptake and addressing inequalities in participation; however, to date, there is a paucity of economic evidence evaluating higher CR participation rates and their relevance to socioeconomic inequality. Methods This study constructed a de-novo cost-effectiveness model of CR, utilising the results from the latest Cochrane review and national CR audit data. We explore the role of socioeconomic status by incorporating key deprivation parameters and determine the population health gains associated with achieving an uptake target of 65%. Results We find that the low cost of CR and the potential for reductions in subsequent MI and revascularisation rates combine to make it a highly cost-effective intervention. While CR is less cost-effective for more deprived groups, the lower level of uptake in these groups makes the potential health gains, from achieving the target, greater. Using England as a model, we estimate the expenditure that could be justified while maintaining the cost-effectiveness of CR at £68.4 m per year. Conclusions Increasing CR uptake is cost-effective and can also be implemented to reduce known socioeconomic inequalities. Using an estimation of potential population health gains and justifiable expenditure, we have produced tools with which policymakers and commissioners can encourage greater utilisation of CR services.
Evolution and Advancement of Adult Spinal Deformity Research and Clinical Care: An Overview of the Scoli-RISK-1 Study
Authors: Cerpa Meghan , Lenke Lawrence G. , Fehlings Michael G. , Shaffrey Christopher I. , Cheung Kenneth M. C. , Carreon Leah Yacat 
Published: May 2019

Study Design: Narrative review. Objective: The prevalence of adult spinal deformity (ASD) has been cited anywhere between 2-32%, while the prevalence in the elderly population has been estimated at 68%. Neurologic complications following ASD surgery remains a concern. Previous literature reported incidence of neurologic complications varied between 1-10%, while non-neurologic complications reported were as high as 50%. To assess the incidence of neurologic deficits, complications, and outcomes following ASD surgery, an international group of spine deformity surgeons initiated a prospective, multicenter, international, observational study: Scoli-RISK-1. Methods: Two hundred seventy-two patients were enrolled from 15 centers with ASD having primary or revision surgery with a major Cobb≥80°, revision including an osteotomy, and/or a complex 3-column osteotomy. Patients had lower extremity muscle strength (LEMS) exams performed preoperatively and at specific time points through 2-year follow-up. Results: Preoperatively, 203 patients (74.9%) had no LEMS impairment (normal) and 68 (25.1%) had a LEMS of <50 (abnormal). Compared with baseline, 23.0% of all patients experienced a LEMS decline at discharge, with this rate decreasing to 17.1% at 6-weeks and to 9.9% at 6-months and remaining stable at 10.0% at 2-years. Conclusion: This study revealed that a decline in LEMS after complex ASD surgery is common and more frequent than previously reported. We identified such a decline in 23.0% of patients at discharge, with neurologic function recovering over time to a decline of 10.0% at 2-years postoperatively. The Scoli-RISK-1 study revealed valuable information regarding the incidence, natural history, and prognosis of neurologic and non-neurologic complications following ASD surgery and provides useful information for patient counseling.
Cell Therapy for Treatment of Intervertebral Disc Degeneration: A Systematic Review
Authors: Meisel Hans-Joerg , Agarwal Neha , Hsieh Patrick C. , Skelly Andrea , Park Jong-Beom , Brodke Darrel , Wang Jeffrey C. , Yoon S. Tim , Buser Zorica 
Published: May 2019

Study Design: Systematic review. Objective: To review, critically appraise, and synthesize evidence on use of cell therapy for intervertebral disc repair. Methods: A systematic search of PubMed/MEDLINE was conducted for literature published through October 31, 2018 and EMBASE and ClinicalTrials.gov databases through April 13, 2018 comparing allogenic or autologous cell therapy for intervertebral disc (IVD) repair in the lumbar or cervical spine. In the absence of comparative studies, case series of ≥10 patients were considered. Results: From 1039 potentially relevant citations, 8 studies across 10 publications on IVD cell therapies in the lumbar spine met the inclusion criteria. All studies were small and primarily case series. For allogenic cell sources, no difference in function or pain between mesenchymal cell treatment and sham were reported in 1 small randomized controlled trial; 1 small case series reported improved function and pain relative to baseline but it was unclear if the change was clinically significant. Similarly for autologous cell sources, limited data across case series suggest pain and function may be improved relative to baseline; whether the changes were clinically significant was not clear. Safety data was sparse and poorly reported. The need for subsequent surgery was reported in 3 case-series studies ranging from 6% to 80%. Conclusions: The overall strength of evidence for efficacy and safety of cell therapy for lumbar IVD repair was very low primarily due to substantial risk of bias, small sample sizes and lack of a comparator intervention. Methodologically sound studies comparing cell therapies to other treatments are needed.
Development and Implementation of Clinical Practice Guidelines: An Update and Synthesis of the Literature With a Focus in Application to Spinal Conditions
Authors: Tetreault Lindsay , Nater Anick , Garwood Philip , Badhiwala Jetan H. , Wilson Jefferson R. , Fehlings Michael G. 
Published: May 2019

Study Design: Review. Objectives: The objectives of this review are to ( a) summarize the role of clinical practice guidelines (CPGs), ( b) outline the methodology involved in formulating CPGs, ( c) provide an illustration of these principles using a CPG developed for degenerative cervical myelopathy, and ( d) highlight the importance of knowledge translation. Methods: A review of the literature was conducted to summarize current standards in CPG development and implementation. Results: CPGs are systematically developed statements intended to affect decisions made by health care providers, policy makers, and patients. The main objectives of CPGs are to synthesize and translate evidence into recommendations, optimize patient outcomes, standardize care, and facilitate shared decision making among physicians, patients, and their caregivers. The main steps involved in the development of CPGs include defining the clinical problem, assembling a multidisciplinary guideline development group and systematic review team, conducting a systematic review of the literature, translating the evidence to recommendations, critically appraising the CPG and updating the document when new studies arise. The final step in developing a CPG is to implement it into clinical practice; this step requires an assessment of the barriers to implementation and the formulation of effective dissemination strategies. Conclusion: CPGs are an important component in the teaching and practice of medicine and are available for a wide spectrum of diseases. CPGs, however, can only be used to influence clinical practice if the recommendations are informed by a systematic review of the literature and developed using rigorous methodology. The opportunity to transform clinical management of spinal conditions is an attractive outcome of the application of high-quality CPGs.
Ognitite, NiBiTe, a new mineral species, and Co-rich maucherite from the Ognit ultramafic complex, Eastern Sayans, Russia
Authors: Barkov Andrei Y. , Bindi Luca , Tamura Nobumichi , Shvedov Gennadiy I. , Winkler Björn , Stan Camelia V. , Morgenroth Wolfgang , Martin Robert F. , Zaccarini Federica , Stanley Christopher J. 
Published: May 2019

AbstractWe describe the new species ognitite, NiBiTe, and a Co-rich variety of maucherite, hitherto unreported; both were discovered in the Ognit ultramafic complex of Neoproterozoic age in Eastern Sayans, Russia. The mean composition of ognitite (n = 7) is: Ni 17.05, Fe 0.07, Cu 0.14, Pd 0.14, Te 32.53, Bi 49.64, total 99.57 wt.%, corresponding to: (Ni1.11Cu0.008Fe0.005Pd0.005)Σ1.13Bi0.90Te0.97 (Σ atoms = 3 apfu). Ognitite is trigonal, space group P3m1 [R1 = 0.0276 for 81 reflections with Fo > 4σ(Fo)]. The unit-cell parameters derived from the single-crystal X-ray diffraction data are: a = 3.928(1) Å, c = 5.385(1) Å and V = 71.95(4) Å3, with Z = 1. The c:a ratio is 1.37. The powder X-ray diffraction data obtained on the same fragment used for the single-crystal study are: a = 3.9332(4) Å, c = 5.3920(6) Å and V = 72.24(1) Å3. Ognitite exhibits the brucite-type structure with edge-sharing NiTe3Bi3 octahedra forming sheets parallel to (0001). It is related to melonite, but is distinct compositionally by the extreme Bi-enrichment (melonite and its synthetic analogue contain <0.4 Bi apfu), and structurally as Bi and Te are ordered at two distinct sites, leading to the loss of the centre of symmetry in ognitite.At more than 9 wt.% Co, or ~2 apfu Co, the core of Co-rich maucherite [(Ni,Co)11As8] in a zoned crystal, which is surrounded by Co-depleted orcelite, far surpasses the norm (≤1 and up to 3.9 wt.% Co). The unit-cell parameters of the Co-rich maucherite are: a = 6.85(2) and c = 21.83(5) Å, which are based on results of synchrotron micro-Laue diffraction.The host rock consists of serpentine, clinochlore (Mg# 95–97) and skeletal chromite. We favour the metastable crystallisation of fluid-saturated globules of a sulfide–arsenide melt to explain the anomalous compositions of ore minerals at Ognit. These anomalies seem consistent with rapid cooling in a fluid-enriched system, possibly related to late-stage degassing of the magma, as reflected in a prominent metasomatic aureole at the contact with the enclosing gneissic rocks.
International approaches to paediatric podiatry curricula: It's the same, but different
Authors: Williams Cylie M. , Nester Chris , Morrison Stewart C. 
Published: May 2019

AbstractIntroductionPre‐registration / entry‐level programmes of study provide the core knowledge, skills and abilities required for clinical practice. These programmes are where students are introduced to specialist domains of practice and begin to shape their professional interests. The aim of this research was to describe paediatric curricula within pre‐registration and entry level podiatry programmes across comparable universities and offer a contemporary synthesis of international practices.MethodsAn exploratory, cross‐sectional, online survey was undertaken across a three‐month period. Representatives from podiatry programmes delivering pre‐registration or entry level podiatry degrees in which graduates are eligible for Professional and Statutory Body registration within their country (deemed at a Bachelor degree or higher), were invited to participate. The survey was administered online using Online Surveys. Descriptive statistics were used to describe the data due to the exploratory nature of the research question and design.ResultsThere were responses from seven (54% of 13) universities in the United Kingdom (UK), nine (100% of nine) universities in Australia and four (50% of eight) of the invited universities external to the UK and Australia (New Zealand, Malta, Ireland, South Africa). There was some variation in curriculum content, but all universities reported to cover ontogeny and developmental milestones and general paediatric orthopaedic conditions. There was further discrepancy with the number of hours dedicated to paediatric podiatry within the curricula (ranging from < 5 h to > 26 h).ConclusionThe findings from this study highlight some disparity in the delivery of training for students relating to paediatrics. The data suggests that there is a need for international coordination in establishing priorities for the paediatric curricula. This will ensure consistency in baseline knowledge, modes of training, amount and nature of curriculum delivery during undergraduate or entry level podiatry training.
Enhanced ground segmentation method for Lidar point clouds in human-centric autonomous robot systems
Authors: Chu Phuong Minh , Cho Seoungjae , Park Jisun , Fong Simon , Cho Kyungeun 
Published: May 2019

Abstract
Ground segmentation is an important step for any autonomous and remote-controlled systems. After separating ground and nonground parts, many works such as object tracking and 3D reconstruction can be performed. In this paper, we propose an efficient method for segmenting the ground data of point clouds acquired from multi-channel Lidar sensors. The goal of this study is to completely separate ground points and nonground points in real time. The proposed method segments ground data efficiently and accurately in various environments such as flat terrain, undulating/rugged terrain, and mountainous terrain. First, the point cloud in each obtained frame is divided into small groups. We then focus on the vertical and horizontal directions separately, before processing both directions concurrently. Experiments were conducted, and the results showed the effectiveness of the proposed ground segment method. For flat and sloping terrains, the accuracy is over than 90%. Besides, the quality of the proposed method is also over than 80% for bumpy terrains. On the other hand, the speed is 145 frames per second. Therefore, in both simple and complex terrains, we gained good results and real-time performance.
Repair, regenerate and reconstruct: meeting the state-of-the-art
Authors: Reuter Hanna , Vogg Matthias Christian , Serras Florenci 
Published: May 2019

ABSTRACT
The seventh EMBO meeting on the Molecular and Cellular Basis of Regeneration and Tissue Repair took place in Valletta, Malta, in September 2018. Researchers from all over the world gathered together with the aim of sharing the latest advances in wound healing, repair and regeneration. The meeting covered a wide range of regeneration models and tissues, identification of regulatory genes and signals, and striking advances toward regenerative therapies. Here, we report some of the exciting topics discussed during this conference, highlighting important discoveries in regeneration and the perspectives for regenerative medicine.
Avian surface reconstruction in free flight with application to flight stability analysis of a barn owl and peregrine falcon
Authors: Durston Nicholas E. , Wan Xue , Liu Jian G. , Windsor Shane P. 
Published: May 2019

ABSTRACTBirds primarily create and control the forces necessary for flight through changing the shape and orientation of their wings and tail. Their wing geometry is characterised by complex variation in parameters such as camber, twist, sweep and dihedral. To characterise this complexity, a multi-view stereo-photogrammetry setup was developed for accurately measuring surface geometry in high resolution during free flight. The natural patterning of the birds was used as the basis for phase correlation-based image matching, allowing indoor or outdoor use while being non-intrusive for the birds. The accuracy of the method was quantified and shown to be sufficient for characterising the geometric parameters of interest, but with a reduction in accuracy close to the wing edge and in some localised regions. To demonstrate the method's utility, surface reconstructions are presented for a barn owl (Tyto alba) and peregrine falcon (Falco peregrinus) during three instants of gliding flight per bird. The barn owl flew with a consistent geometry, with positive wing camber and longitudinal anhedral. Based on flight dynamics theory, this suggests it was longitudinally statically unstable during these flights. The peregrine falcon flew with a consistent glide angle, but at a range of air speeds with varying geometry. Unlike the barn owl, its glide configuration did not provide a clear indication of longitudinal static stability/instability. Aspects of the geometries adopted by both birds appeared to be related to control corrections and this method would be well suited for future investigations in this area, as well as for other quantitative studies into avian flight dynamics.
A Modeling Approach for Evaluating Watershed-scale Water Quality Benefits of Vegetative Filter Strip - A Case Study in Ontario
Authors: Gupta Anand Krishna , Rudra Ramesh Pal , Gharabaghi Bahram , Goel Pradeep Kumar , Sebti Saleh , Shukla Rituraj , Daggupati Prasad 
Published: May 2019

Abstract. Vegetative filter strips (VFS) are globally recognized as an effective BMP in reducing non-point source pollution. Maximum effectiveness of a VFS at a watershed-level could be achieved by adequately installing and sizing a VFS along the edge of the field. Existing watershed models have limitations in appropriately representing and modeling VFS at the watershed scale. Therefore, in this research, a new modeling approach consisting of the Agricultural Non-Point Source (AGNPS) model, AGNPS_VFS toolkit, and a regression equation is developed to explore the effectiveness of VFS applied along the edge of fields. AGNPS cells are identified as locations where the edge of the field VFS is to be installed. Further, the approach was tested with a case study. The model was calibrated and validated for a flow and sediment load at the watershed outlet. Thereafter, the modeling approach is used to compute sediment reducing efficiency (SRE) for the edge of the field VFS. Objectives of this study were to test the effectiveness of uniform VFS (5 × 18 m) lengths located at several locations (draining an upstream area of 3, 4, 6 ha, and at spatially variable locations) within a watershed to demonstrate the ability of the developed approach to evaluate effectiveness of VFS application in sediment abatement. Maximum SRE was observed for VFS placed at spatially variable locations; the developed approach reduced nearly 23.03% of sediment yield, while VFS placed along cells draining an upstream area of 3, 4, and 6 ha removed 9.59%, 12.39%, and 5.91% of sediment loads respectively. Keywords: Non-point source pollution, Sediment transport, Vegetative filter strip (VFS), VFSMOD.