bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of stakeholder relations with multi-person aggregation
Authors: Blanco-Mesa Fabio , Gil-Lafuente Anna Maria , Merigo Jose M. 
Published: April 2018

Purpose
The purpose of this paper is to develop a novel method to analyse dynamic interactions of stakeholders to explain how a set of agents can act by considering the power/influence positions.

Design/methodology/approach
A novel mathematical application uses the importance of characteristics algorithm in combination with composition max-min to compare, group and order information according to the importance of its characteristics. The mathematical application is focused on a strategic analysis, evaluating stakeholder dynamics through power relationships.

Findings
The results show a comparison of the relationships among each of the stakeholders to obtain the relative intensity and importance of relationships between them, given by the fuzzy matrix FRInM and the fuzzy matrix FRIM, respectively. This application provides a useful tool for a dynamic analysis of stakeholders in a complex environment, where the best approach to performing a strategic analysis process is sought.

Research limitations/implications
The main implication of the proposed approach is taking into account the importance of information to establish the boundaries and relationships of each characteristic according to its intensity. However, limitations are due to the nature of this research, based on theoretical assumptions regarding stakeholders and the use of a hypothetical example to show the operation of algorithms.

Originality/value
The primary advantage of this proposition is that it takes into account the importance of information to establish the relationships among the characteristics according to their intensity. In addition, it performs multiple comparisons among each characteristic of the information. The interests and opinions of decision makers can be parameterised. A mathematical application shows how each interest group could be classified and related according to subjective information.
A Paleogeographic and Depositional Model for the Neogene Fluvial Succession, Pishin Belt, Northwest Pakistan: Effect of Post Collisional Tectonics on Sedimentation in a Peripheral Foreland Setting
Authors: KASI Aimal K. , KASSI Akhtar M. , UMAR Muhammad , FRIIS Henrik , MOHIBULLAH Mohibullah , MANAN Razzaq A. 
Published: April 2018

AbstractDetailed facies analysis of the Neogene successions of the Pishin Belt (Katawaz Basin) has enabled documentation of successive depositional systems and paleogeographic settings of the basin formed by the collision of the northwestern continental margin of the Indian Plate and the Afghan Block. During the Early Miocene, subaerial sedimentation started after the final closure of the Katawaz Remnant Ocean. Based on detailed field data, twelve facies were recognized in Neogene successions exposed in the Pishin Belt. These facies were further organized into four facies associations i.e. channels, crevasse splay, natural levee and floodplain facies associations. Facies associations and variations provided ample evidence to recognize a number of fluvial architectural components in the succession e.g., low‐sinuosity sandy braided river, mixed‐load meandering, high‐sinuosity meandering channels, single‐story sandstone and/or conglomerate channels, lateral accretion surfaces (point bars) and alluvial fans. Neogene sedimentation in the Pishin Belt was mainly controlled by active tectonism and thrusting in response to the oblique collision of the Indian Plate with the Afghan Block of the Eurasian Plate along the Chaman‐Nushki Fault. Post Miocene deformation of these formations successively caused them to contribute as an additional source terrain for the younger formations.
Dual Control of Depositional Facies on Uranium Mineralization in Coal‐bearing Series: Examples from the Tuanyushan Area of the Northern Qaidam Basin, NW China
Authors: GUO Biao , SHAO Longyi , WEN Huaijun , HUANG Guangnan , ZOU Mingjun , LI Yonghong 
Published: April 2018

AbstractThe uranium deposits in the Tuanyushan area of northern Qaidam Basin commonly occur in coal‐bearing series. To decipher the U‐enrichment mechanism and controlling factors in this area, a database of 72 drill cores, including 56 well‐logs and 3 sampling wells, was examined for sedimentology and geochemistry in relation to uranium concentrations. The results show that coal‐bearing series can influence uranium mineralization from two aspects, i.e., spatial distribution and dynamic control. Five types of uranium‐bearing rocks are recognized, mainly occurring in the braided river and braided delta sedimentary facies, among which sandstones near the coals are the most important. The lithological associations of sandstone‐type uranium deposits can be classified into three subtypes, termed as U‐coal type, coal‐U‐coal type, and coal‐U type, respectively. The coal and fine siliciclastic rocks in the coal‐bearing series confined the U‐rich fluid flow and uranium accumulation in the sandstone near them. Thus, the coal‐bearing series can provide good accommodations for uranium mineralization. Coals and organic matters in the coal‐bearing series may have served as reducing agents and absorbing barriers. Methane is deemed to be the main acidolysis hydrocarbon in the U‐bearing beds, which shows a positive correlation with U‐content in the sandstones in the coal‐bearing series. Additionally, the δ13C in the carbonate cements of the U‐bearing sandstones indicates that the organic matters, associated with the coal around the sandstones, were involved in the carbonation, one important component of alteration in the Tuanyushan area. Recognition of the dual control of coal‐bearing series on the uranium mineralization is significant for the development of coal circular economy, environmental protection during coal utilization and the security of national rare metal resources.
How Often Do Safety Signals Occur by Chance in First‐in‐Human Trials?
Authors: Clayton Gemma L. , Schachter Asher D. , Magnusson Baldur , Li Yue , Colin Laurence 
Published: April 2018

AbstractClinicians working on first‐in‐human clinical studies need to be able to judge whether safety signals observed on an investigational drug were more likely to have occurred by chance or to have been caused by the drug. We retrospectively reviewed 84 Novartis studies including 1,234 healthy volunteers receiving placebo to determine the expected incidence of changes in commonly measured laboratory parameters and vital signs, in the absence of any active agent. We calculated the frequency of random incidence of safety signals, focusing on the liver, cardiovascular system, kidney, and pancreas. Using the liver enzyme alanine aminotransferase (ALT) as an example, we illustrate how a predictive model can be used to determine the probability of a given subject to experience an elevation of ALT above the upper limit of the normal range under placebo, conditional on the characteristics of this subject and the study.
Physical deterioration in an acute mental health unit: A quantitative retrospective analysis of medical emergencies
Authors: Porter Joanne E. , Cant Robyn , Missen Karen , Raymond Anita , Churchill Anne 
Published: April 2018

AbstractNursing management of physical deterioration of patients within acute mental health settings is observed, recorded, and actively managed with the use of standardized Adult Deterioration Detection System (ADDS) charts. Patient deterioration may require the urgent assistance of a hospital rapid response or Medical Emergency Team. A five‐and‐a‐half‐year (2011–2016) audit of hospital‐wide Medical Emergency Team attendances was conducted in an acute mental health unit of a single large 250 bed regional hospital in Victoria, Australia. Data were extracted from the hospitals’ quality and patient safety program,RISKMan, and entered into a statistical data program for analysis. A total of 140 patient records were analysed, and the ‘Worried’ category (34%,n = 47) was the principle reason for a Medical Emergency Team call in a mental health ward, followed by hypotension (23%,n = 31) and a low Glasgow Coma Score (16%,n = 22). Upon further investigation of the ‘Worried’ category, the most common conditions recorded were an altered conscious state (22%,n = 9), low oxygen saturation (20%,n = 8), or chest pain (17%,n = 7). Activation of Medical Emergency Team calls predominantly occurred in the daylight morning hours (6am–12md). When data were compared to the general hospital patients, the context of the physiological deterioration of the mental health patients was strikingly similar. Further research is recommended to ascertain the extent and frequency with which staff working in mental health units are performing vital signs monitoring as an essential component of detection of early signs of physiological deterioration.
Countercyclical Policy and the Speed of Recovery after Recessions
Authors: FRANCIS NEVILLE , JACKSON LAURA E. , OWYANG MICHAEL T. 
Published: April 2018

AbstractWe consider policies intended to accelerate recoveries by analyzing the duration of recoveries of U.S. states. Studying multiple recessions for a state and multiple states for a recession controls for differences in the economic conditions and the causes of recessions. Expansionary monetary policy at the national level helps to stimulate the exit of individual states from recession. Exogenous measures of decreases in taxes or targeted increases in federal spending reduce state recovery times, while ambient economic conditions (other states in the same region suffering from recession, the length of the preceding recession, and increases in oil prices) extend recovery times.
Eastern Orthodoxy and national indifference in Habsburg Bukovina, 1774–1873
Authors: Leustean Lucian N. 
Published: April 2018

AbstractBukovina, a predominantly Eastern Orthodox land, today divided between northern Romania and southwestern Ukraine, was the outmost frontier of the Habsburg Empire. Between its incorporation into the Empire in 1774 and Greater Romania in 1918, Bukovina produced an unusual Church. Rather than support a mono‐ethnic Orthodox community, as evident across nation building processes in Southeastern Europe, in 1873, Romanians, Ruthenians and Serbians (in Dalmatia) established a multi‐ethnic Church which rejected association with that of their Romanian brethren in Habsburg Transylvania. This article explores the lead up to the establishment of the church in 1873 and argues that, under the leadership of Bishop Eugen Hakmann, the Metropolitanate of Bukovina and Dalmatia was a novel ecclesiastical institution in which the clergy refused national identification while laypeople supported the growing rise of nationalist movements. This multi‐ethnic Church became one of the most intriguing Orthodox structures which would impact upon the emergence of national churches in nineteenth‐century Romania, Serbia and Ukraine.
Light‐emitting Diode Blue Light Alters the Ability of Penicillium digitatum to Infect Citrus Fruits
Authors: Lafuente María T. , Alférez Fernando , González‐Candelas Luis 
Published: April 2018

AbstractPenicillium digitatum (Pers.:Fr.) Sacc. is the main fungus causing postharvest losses in citrus fruits. Previous work showed the potential of LED blue light (LBL) in controlling P. digitatum growth. Here, we have investigated whether LBL alters the ability of this fungus to infect citrus fruits. Before fruit infection, Petri plates inoculated with the same conidia concentration were held under darkness (control) or LBL (100 μmol m−2 s−1) for 8 d (continuous light), or were treated with the same LBL for 3 d and then shifted to darkness for 5 d (non‐continuous light). Spores from cultures exposed to continuous light showed very low capacity to germinate (1.8% respect to control) but a high viability and a similar morphology and ability to infect the fruits than spores from control cultures. The number of spores produced in plates exposed to non‐continuous light was slightly lower than in control plates, but they showed much lower viability and lower capacity to infect the fruits. This effect was more likely related to aberrant morphology of spores, which formed aggregates, than to its metabolic activity or its ability to produce ethylene that might contribute to destroy natural defense barriers from the fruit.
Quantification of Leptospira interrogans Survival in Soil and Water Microcosms
Authors: Casanovas-Massana Arnau , Pedra Gabriel Ghizzi , Wunder Elsio A. , Diggle Peter J. , Begon Mike , Ko Albert I. 
Published: April 2018

ABSTRACT

Leptospira interrogans
is the etiological agent of leptospirosis, a globally distributed zoonotic disease. Human infection usually occurs through skin exposure with water and soil contaminated with the urine of chronically infected animals. In this study, we aimed to quantitatively characterize the survival of
Leptospira interrogans
serovar Copenhageni in environmental matrices. We constructed laboratory microcosms to simulate natural conditions and determined the persistence of DNA markers in soil, mud, spring water and sewage using a quantitative PCR (qPCR) and a propidium monoazide (PMA)-qPCR assay. We found that
L. interrogans
does not survive at high concentrations in the tested matrices. No net growth was detected in any of the experimental conditions and in all cases the concentration of the DNA markers targeted decreased from the beginning of the experiment following an exponential decay with a decreasing decay rate over time. After 12 and 21 days of incubation the spiked concentration of 10
6
L. interrogans
cells/ml or g decreased to approximately 100 cells/ml or g in soil and spring water microcosms, respectively. Furthermore, culturable
L. interrogans
persisted at concentrations under the limit of detection by PMA-qPCR or qPCR for at least 16 days in soil and 28 days in spring water. Altogether, our findings suggest that the environment is not a multiplication reservoir but a temporary carrier of
L. interrogans
Copenhageni, although the observed prolonged persistence at low concentrations may still enable the transmission of the disease.

IMPORTANCE
Leptospirosis is a zoonotic disease caused by spirochetes of the genus
Leptospira
that primarily affects impoverished populations worldwide. Although leptospirosis is transmitted by contact with water and soil, little is known about the ability of the pathogen to survive in the environment. In this study, we quantitatively characterized the survival of
L. interrogans
in environmental microcosms and found that although it cannot multiply in water, soil or sewage, it survives for extended time periods (days to weeks depending on the matrix). The survival parameters obtained here may help to better understand the distribution of pathogenic
Leptospira
in the environment and improve the predictions of human infection risks in areas where such infections are endemic.
Public performance reporting and hospital choice: a cross-sectional study of patients undergoing cancer surgery in the Australian private healthcare sector
Authors: Prang Khic-Houy , Canaway Rachel , Bismark Marie , Dunt David , Miller Julie A. , Kelaher Margaret 
Published: April 2018

ObjectivesNational mandatory public performance reporting (PPR) for Australian public hospitals, including measures of cancer surgery waiting times, was introduced in 2011. PPR is voluntary for private hospitals. The aims of this study were to assess whether PPR of hospital data is used by patients with breast, bowel or lung cancer when selecting a hospital for elective surgery and how PPR could be improved to meet their information needs.DesignA national cross-sectional postal questionnaire.SettingAustralian private healthcare sector.ParticipantsPrivate patients with breast, bowel or lung cancer who attended a public or private hospital for elective surgery (n=243) in 2016.Outcome measuresPatients’ choice of hospital, use of PPR information and preferred areas of PPR information. Descriptive and conventional qualitative content analyses were conducted.ResultsTwo hundred and twenty-eight respondents (94%) attended a private hospital. Almost half could choose a hospital. Choice of hospital was not influenced by PPR data (92% unaware) but by their specialist (90%). Respondents considered PPR to be important (71%) but they did not want to see the information, preferring their general practitioners (GPs) to tell them about it (40%). Respondents considered surgery costs (59%), complications (58%) and recovery success rates (57%) to be important areas of information that should be publicly reported. Almost half suggested that quality indicators should be reported at the individual clinician level. Analysis of the open-ended questions identified four themes: (1) decision-making factors; (2) data credibility; (3) unmet information needs and (4) unintended consequences.ConclusionsPPR of hospital data had no substantial impact on patients’ choice of hospital. Nonetheless, many respondents expressed interest in using it in future. To increase PPR awareness and usability, personalised and integrated information on cost and quality of hospitals is required. Dissemination of PPR information via specialists and GPs could assist patients to interpret the data and support decision-making.
The relationship between sleep duration and fruit/vegetable intakes in UK adults: a cross-sectional study from the National Diet and Nutrition Survey
Authors: Noorwali Essra A , Cade Janet E , Burley Victoria J , Hardie Laura J 
Published: April 2018

ObjectivesThere is increasing evidence to suggest an association between sleep and diet. The aim of the present study was to examine the association between sleep duration and fruit/vegetable (FV) intakes and their associated biomarkers in UK adults.DesignCross-sectional.SettingData from The National Diet and Nutrition Survey.Participants1612 adults aged 19–65 years were included, pregnant/breastfeeding women were excluded from the analyses.Outcome measuresSleep duration was assessed by self-report, and diet was assessed by 4-day food diaries, disaggregation of foods containing FV into their components was conducted to determine total FV intakes. Sleep duration was divided into: short (<7 hours/day), reference (7–8 hours/day) and long (>8 hours/day) sleep periods. Multiple regression adjusting for confounders was used for analyses where sleep duration was the exposure and FV intakes and their associated biomarkers were the outcomes. Restricted cubic spline models were developed to explore potential non-linear associations.ResultsIn adjusted models, long sleepers (LS) consumed on average 28 (95% CI −50 to −6, p=0.01) g/day less of total FV compared to reference sleepers (RS), whereas short sleepers (SS) consumed 24 g/day less (95% CI −42 to –6, p=0.006) and had lower levels of FV biomarkers (total carotenoids, β-carotene and lycopene) compared to RS. Restricted cubic spline models showed that the association between sleep duration and FV intakes was non-linear (p<0.001) with RS having the highest intakes compared to SS and LS. The associations between sleep duration and plasma total carotenoids (p=0.0035), plasma vitamin C (p=0.009) and lycopene (p<0.001) were non-linear with RS having the highest levels.ConclusionsThese findings show a link between sleep duration and FV consumption. This may have important implications for lifestyle and behavioural change policy.
Theodor W. Adorno on ‘Marx and the Basic Concepts of Sociological Theory’
Authors: Adorno Theodor W. , Erlenbusch-Anderson Verena , O’Kane Chris 
Published: April 2018

Abstract
The following is the transcript of a lecture taken in shorthand by Hans-Georg Backhaus. The transcript was originally published as an appendix in Hans-Georg Backhaus, Dialektik der Wertform. Untersuchungen zur marxschen Ökonomiekritik (Freiburg: ça ira, 1997), a complete translation of which is forthcoming in the Historical Materialism book series.
The Old Adam, After All
Authors: Thorne Christian 
Published: April 2018

AbstractHill and Montag’s The Other Adam Smith confirms many of the Left’s established positions on Adam Smith, but does so by framing the philosopher as a standard-bearer of the Scottish Enlightenment, and not just as an arch-capitalist and proto-Hayekian. The book makes a strong case, but also strong-arms its readers into choosing between the Scottish Enlighteners and the Spinozism that its authors prefer.
CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML
Authors: Lucas Claire M. , Scott Laura J. , Carmell Natasha , Holcroft Alison K. , Hills Robert K. , Burnett Alan K. , Clark Richard E. 
Published: April 2018

Key Points
PP2A inhibition occurs in AML by 2 different pathways: CIP2A in normal karyotype patients and SETBP1 in adverse karyotype patients. AKTS473 phosphorylation is a predictor of survival, and diagnostic levels of AKTS473 could be a novel biomarker in AML.
Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia
Authors: Morita Kiyomi , Kantarjian Hagop M. , Wang Feng , Yan Yuanqing , Bueso-Ramos Carlos , Sasaki Koji , Issa Ghayas C. , Wang Sa , Jorgensen Jeffrey , Song Xingzhi , Zhang Jianhua , Tippen Samantha , Thornton Rebecca , Coyle Marcus , Little Latasha , Gumbs Curtis , Pemmaraju Naveen , Daver Naval , DiNardo Courtney D. , Konopleva Marina , Andreeff Michael , Ravandi Farhad , Cortes Jorge E. , Kadia Tapan , Jabbour Elias , Garcia-Manero Guillermo , Patel Keyur P. , Futreal P. Andrew , Takahashi Koichi 
Published: April 2018

Purpose The aim of the current study was to determine whether the degree of mutation clearance at remission predicts the risk of relapse in patients with acute myeloid leukemia (AML). Patients and Methods One hundred thirty-one previously untreated patients with AML who received intensive induction chemotherapy and attained morphologic complete remission (CR) at day 30 were studied. Pretreatment and CR bone marrow were analyzed using targeted capture DNA sequencing. We analyzed the association between mutation clearance (MC) on the basis of variant allele frequency (VAF) at CR (MC2.5: if the VAF of residual mutations was < 2.5%; MC1.0: if the VAF was < 1%; and complete MC [CMC]: if no detectable residual mutations) and event-free survival, overall survival (OS), and cumulative incidence of relapse (CIR). Results MC1.0 and CMC were associated with significantly better OS (2-year OS: 75% v 61% in MC1.0 v non-MC1.0; P = .0465; 2-year OS: 77% v 60% in CMC v non-CMC; P = .0303) and lower CIR (2-year CIR: 26% v 46% in MC1.0 v non-MC 1.0; P = .0349; 2 year-CIR: 24% v 46% in CMC v non-CMC; P = .03), whereas there was no significant difference in any of the above outcomes by MC2.5. Multivariable analysis adjusting for age, cytogenetic risk, allogeneic stem-cell transplantation, and flow cytometry–based minimal residual disease revealed that patients with CMC had significantly better event-free survival (hazard ratio [HR], 0.43; P = .0083), OS (HR, 0.47; P = .04), and CIR (HR, 0.27; P < .001) than did patients without CMC. These prognostic associations were stronger when preleukemic mutations, such as DNMT3A, TET2, and ASXL1, were removed from the analysis. Conclusion Clearance of somatic mutation at CR, particularly in nonpreleukemic genes, was associated with significantly better survival and less risk of relapse. Somatic mutations in nonpreleukemic genes may function as a molecular minimal residual disease marker in AML.