bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of the Occurrence of Ion Upflow in Association With Ion/Electron Heating in the Polar Ionosphere
Authors: Ji Eun‐Young , Jee Geonhwa , Lee Changsup 
Published: July 2019

AbstractWe investigate the statistical characteristics of the ion upflow occurrence in association with ion and electron heatings in the polar ionosphere using the European Incoherent Scatter Svalbard Radar during the period of 2000–2015. The ion upflow events are classified as four types: with ion temperature increase (Type 1), with electron temperature increase (Type 2), with both ion and electron temperature increases (Type 3), and without any temperature increase (Type 4). These four types of upflow events are statistically analyzed with various geophysical conditions. We found that the overall occurrence of ion upflow is highest for Type 3 and then followed by Type 2, Type 1, and Type 4. This result indicates that the ion upflow is highly associated with soft particle precipitation induced electron heating, which becomes more effective with simultaneous friction induced ion heating. The statistical characteristics of ion upflow is summarized as follows: (1) It is most highly distributed in the daytime with a double peak structure but a deep minimum at dusk, (2) the highest occurrence appears at about 350‐ to 450‐km altitude for most of local time but extended to higher altitude near the magnetic local noon, (3) the ions mostly reach only up to about 200 km above their initiated altitudes, (4) it tends to increase with magnetic activity, particularly during the daytime, but (5) decreases and distributed at higher altitude with increasing solar activity, and (6) finally, the maximum occurrence appears in December solstice but the minimum in June solstice for most of local times.
Global Ionosphere Estimation Based on Data Fusion From Multisource: Multi‐GNSS, IRI Model, and Satellite Altimetry
Authors: An X. , Meng X. , Jiang W. , Chen H. , He Q. , Xi R. 
Published: July 2019

AbstractTraditionally, the ionosphere determination just uses American Global Positioning System and Russian GLObal NAvigation Satellite System dual‐frequency data and has a low precision particularly on oceans. With the rapid development of Chinese BeiDou and European Galileo systems, they are playing an increasingly important role for modeling global ionosphere. Meanwhile, satellite altimetry provides valuable and precise ionosphere delay over the oceans. Through introducing priori ionosphere values from an advanced empirical ionosphere model, combining the advantages of Global Navigation Satellite System (GNSS) and satellite altimetry technologies, the precision of global ionosphere estimation can be further improved. To assess the improvement, we collect satellite altimetry data from Jason‐2/3 and more than 300 global GNSS stations, the data are processed in 2014 and 2018 when the Sun is in a high and a low activity conditions. The results suggest that the ionosphere determination based on multitechnique fusion in a solar‐geomagnetic reference frame is well suitable to represent the ionosphere and its structure. The determined ionosphere achieves a better global consistency, and its formal accuracy is significantly reduced. By comparing with the International GNSS Service products, evaluating by satellite altimetry measurements, and independently validating with ionosonde techniques, it is proved that the ionosphere results are further improved through employing additional available data, especially for the ionosphere over the oceans.
Effects of the MY34/2018 Global Dust Storm as Measured by MSL REMS in Gale Crater
Authors: Viúdez‐Moreiras D. , Newman C. E. , de la Torre M. , Martínez G. , Guzewich S. , Lemmon M. , Pla‐García J. , Smith M. D. , Harri A.‐M. , Genzer M. , Vicente‐Retortillo A. , Lepinette A. , Rodriguez‐Manfredi J. A. , Vasavada A. R. , Gómez‐Elvira J. 
Published: July 2019

AbstractThe Rover Environmental Monitoring Station (REMS) instrument is on board NASA's Mars Science Laboratory (MSL) Curiosity rover. REMS has been measuring surface pressure, air, and ground brightness temperature, relative humidity, and ultraviolet (UV) irradiance since MSL's landing in 2012. In Mars Year (MY) 34 (2018) a global dust storm reached Gale Crater at Ls ~ 190°. REMS offers a unique opportunity to better understand the impact of a global dust storm on local environmental conditions, which complements previous observations by the Viking landers and Mars Exploration Rovers. All atmospheric variables measured by REMS are strongly affected albeit at different times. During the onset phase, the daily maximum UV radiation decreased by 90% between sols 2075 (opacity ~1) and 2085 (opacity ~8.5). The diurnal range in ground and air temperatures decreased by 35 and 56 K, respectively, with also a diurnal‐average decrease of ~2 and 4 K respectively. The maximum relative humidity, which occurs right before sunrise, decreased to below 5%, compared with prestorm values of up to 29%, due to the warmer air temperatures at night, while the inferred water vapor abundance suggests an increase during the storm. Between sols 2085 and 2130, the typical nighttime stable inversion layer was absent near the surface as ground temperatures remained warmer than near‐surface air temperatures. Finally, the frequency domain behavior of the diurnal pressure cycle shows a strong increase in the strength of the semidiurnal and terdiurnal modes peaking after the local opacity maximum, also suggesting differences in the dust abundance inside and outside Gale.
Combining Numerical and Statistical Models to Predict Storm‐Induced Dune Erosion
Authors: Santos V. M. , Wahl T. , Long J. W. , Passeri D. L. , Plant N. G. 
Published: July 2019

AbstractDune erosion is an important aspect to consider when assessing coastal flood risk, as dune elevation loss makes the protected areas more susceptible to flooding. However, most advanced dune erosion numerical models are computationally expensive, which hinders their application in early‐warning systems. Based on a combination of probabilistic and process‐based numerical modeling, we develop an efficient statistical tool to predict dune erosion during storms. The analysis focuses on Dauphin Island, AL, in the northern Gulf of Mexico, where we combine synthetic sea storms with a calibrated and validated XBeach model to develop and test a range of different surrogate models for their ability to predict barrier island geometric parameters under storm conditions. Surrogate models are developed by combining the oceanographic forcing from 100 optimally sampled sea storm events covering the entire multivariate parameter space (used as XBeach input) and associated changes in the dune system (XBeach output). We test four surrogate models using a k‐fold approach for validation. All models perform well in predicting changes in dune elevation, barrier island area, and width but are less accurate in predicting alterations in the cross‐shore locations of dune morphological features. Multivariate adaptive regression splines is identified as the best surrogate model based on its fast development and good performance, attaining a modified Mielke index of 0.81 for dune crest height. As demonstrated at Dauphin Island, our approach shows potential to be used in an operational framework to predict dune response (in particular crest elevation change) when water level and wave forecasts are available.
Cardioprotective role of APIP in myocardial infarction through ADORA2B
Authors: Lim Bitna , Jung Kwangmin , Gwon Youngdae , Oh Jae Gyun , Roh Jae-il , Hong Se-Hoon , Kho Changwon , Park Woo-Jin , Lee Han-Woong , Bae Jang-Whan , Jung Yong-Keun 
Published: July 2019

AbstractIn ischemic human hearts, the induction of adenosine receptor A2B (ADORA2B) is associated with cardioprotection against ischemic heart damage, but the mechanism underlying this association remains unclear. Apaf-1-interacting protein (APIP) and ADORA2B transcript levels in human hearts are substantially higher in patients with heart failure than in controls. Interestingly, the APIP and ADORA2B mRNA levels are highly correlated with each other (R = 0.912). APIP expression was significantly increased in primary neonatal cardiomyocytes under hypoxic conditions and this induction reduced myocardial cell death via the activation of the AKT-HIF1α pathway. Accordingly, infarct sizes of APIP transgenic mice after left anterior descending artery ligation were significantly reduced compared to those of wild-type mice. Strikingly, knockdown of APIP expression impaired the cytoprotective effects of ADORA2B during hypoxic damage. Immunoprecipitation and proximity ligation assays revealed that APIP interacts with ADORA2B, leading to the stabilization of both proteins by interfering with lysosomal degradation, and to the activation of the downstream PKA-CREB signaling pathways. ADORA2B levels in the hearts of APIPTg/Tg, APIPTg/+, and Apip+/- mice were proportionally downregulated. In addition, ADORA2B D296G derived from the rs200741295 polymorphism failed to bind to APIP and did not exert cardioprotective activity during hypoxia. Moreover, Adora2b D296G knock-in mice were more vulnerable than control mice to myocardial infarction and intentional increases in APIP levels overcame the defective protection of the ADORA2B SNP against ischemic injury. Collectively, APIP is crucial for cardioprotection against myocardial infarction by virtue of binding to and stabilizing ADORA2B, thereby dampening ischemic heart injury.
Positive expression of basic transcription factor 3 predicts poor survival of colorectal cancer patients: possible mechanisms involved
Authors: Liu Qi , Wu Junjie , Lu Tailiang , Fang Zhixue , Huang Zixuan , Lu Shanzheng , Dai Chen , Li Mengqian 
Published: July 2019

AbstractBasic transcription factor 3 (BTF3) is associated with the development of several cancers. The aim of our study was to elucidate the role of BTF3 in colorectal cancer (CRC) tissues. CRC tissues or their paired adjacent noncancerous (ANCT) tissues were obtained from 90 patients who underwent operations in our hospital from November 2011 to December 2016, and then we implemented a gene microarray assay for detecting significant changes in gene expression and confirmed expression in tissues using immunohistochemistry and real-time PCR. We transfected or injected the silencing BTF3 (BTF3-siRNA) plasmid into cells and nude mice, and measured the tumorigenicity of CRC cells with flow cytometry and studied the expression level of BTF3 downstream genes (MAD2L2, MCM3 and PLK1) in CRC cells. BTF3 expression level was not only significantly higher in CRC tissue than in ANCT tissue (2.61 ± 0.07 vs 1.90 ± 0.03,P < 0.001) but BTF3-siRNA decreased tumor formation in a nude mice model. Furthermore, based on the data of gene microarray analysis, MAD2L2, MCM3 and PLK1 were detected as the downstream target genes of BTF3 and their expressions were positive related with BTF3 expression. Also, through transfecting BTF3-siRNA into HCT116 cells, we found that BTF3-siRNA could decrease cell viability and induced cell apoptosis and blocking the cell cycle. In conclusion, BTF3 is positively related to CRC and BTF3-siRNA attenuated the tumorigenicity of colorectal cancer cells via MAD2L2, MCM3 and PLK1 activity reduction.
Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels
Authors: Kilarski Witold W. , Martin Coralie , Pisano Marco , Bain Odile , Babayan Simon A , Swartz Melody A. 
Published: July 2019

AbstractFilariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors assisting in filariae dissemination, we imageLitomosoides sigmodontisinfective larvae during their escape from the skin. Burrowing through the dermis filariae exclusively enter pre-collecting lymphatics by mechanical disruption of their wall. Once inside collectors, their rapid and unidirectional movement towards the lymph node is supported by the morphology of lymphatic valves. In a microfluidic maze mimicking lymphatic vessels, filariae follow the direction of the flow, the first biomechanical factor capable of helminth guidance within the host. Finally, non-infective nematodes that rely on universal morpho-physiological cues alone also migrate through the dermis, and break in lymphatics, indicating that the ability to spread by the lymphatic route is an ancestral trait rather than acquired parasitic adaptation.
Impact of ocean acidification on crystallographic vital effect of the coral skeleton
Authors: Coronado Ismael , Fine Maoz , Bosellini Francesca R. , Stolarski Jarosław 
Published: July 2019

AbstractDistinguishing between environmental and species-specific physiological signals, recorded in coral skeletons, is one of the fundamental challenges in their reliable use as (paleo)climate proxies. To date, characteristic biological bias in skeleton-recorded environmental signatures (vital effect) was shown in shifts in geochemical signatures. Herein, for the first time, we have assessed crystallographic parameters of bio-aragonite to study the response of the reef-building coral Stylophora pistillata to experimental seawater acidification (pH 8.2, 7.6 and 7.3). Skeletons formed under high pCO2 conditions show systematic crystallographic changes such as better constrained crystal orientation and anisotropic distortions of bio-aragonite lattice parameters due to increased amount of intracrystalline organic matrix and water content. These variations in crystallographic features that seem to reflect physiological adjustments of biomineralizing organisms to environmental change, are herein called crystallographic vital effect (CVE). CVE may register those changes in the biomineralization process that may not yet be perceived at the macromorphological skeletal level.
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
Authors: Han Qifeng , Jones Julia A. , Nicely Nathan I. , Reed Rachel K. , Shen Xiaoying , Mansouri Katayoun , Louder Mark , Trama Ashley M. , Alam S. Munir , Edwards Robert J. , Bonsignori Mattia , Tomaras Georgia D. , Korber Bette , Montefiori David C. , Mascola John R. , Seaman Michael S. , Haynes Barton F. , Saunders Kevin O. 
Published: July 2019

AbstractThe HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing antibodies (bnAbs) but not for third variable region (V3) antibodies. Here we show that select V3 macaque antibodies elicited by Env vaccination can neutralize 26% of otherwise tier 2 HIV-1 isolates in standardized virus panels. The V3 antibodies only bound to Env in its open conformation. Thus, Envs on tier 2 viruses sample a state where the V3 loop is not in its closed conformation position. Envelope second variable region length, glycosylation sites and V3 amino acids were signatures of neutralization sensitivity. This study determined that open conformations of Env with V3 exposed are present on a subset of otherwise neutralization-resistant virions, therefore neutralization of tier 2 HIV-1 does not always indicate bnAb induction.
Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: A meta-analysis
Authors: Yau Tung On , Tang Ceen-Ming , Harriss Elinor K. , Dickins Benjamin , Polytarchou Christos 
Published: July 2019

AbstractMicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases identified 17 research articles including 6475, 783 and 5569 faecal-based miRNA tests in CRC, adenoma patients and healthy individuals, respectively. Sensitivity, specificity, positive/negative likelihood and diagnostic odds ratios, area under curve (AUC), summary receiver operator characteristic (sROC) curves, association of individual or combinations of miRNAs to cancer stage and location, subgroup, meta-regression and Deeks’ funnel plot asymmetry analyses were employed. Pooled miRNAs for CRC had an AUC of 0.811, with a sensitivity of 58.8% (95% confidence interval [CI]: 51.7–65.5%) and specificity of 84.8% (95% CI: 81.1–87.8%), whilst for colonic adenoma, it was 0.747, 57.3% (95% CI: 40.8–72.3%) and 76.1% (95% CI: 66.1–89.4%), respectively. The most reliable individual miRNA was miR-21, with an AUC of 0.843, sensitivity of 59.3% (95% CI: 26.3–85.6%) and specificity of 85.6% (95% CI: 72.2–93.2%). Paired stage analysis showed a better diagnostic accuracy in late stage CRC and sensitivity higher in distal than proximal CRC. In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening.
Global ozone depletion and increase of UV radiation caused by pre-industrial tropical volcanic eruptions
Authors: Brenna Hans , Kutterolf Steffen , Krüger Kirstin 
Published: July 2019

AbstractLarge explosive tropical volcanic eruptions inject high amounts of gases into the stratosphere, where they disperse globally through the large-scale meridional circulation. There is now increasing observational evidence that volcanic halogens can reach the upper troposphere and lower stratosphere. Here, we present the first study that combines measurement-based data of sulfur, chlorine and bromine releases from tropical volcanic eruptions with complex coupled chemistry climate model simulations taking radiative-dynamical-chemical feedbacks into account. Halogen model input parameters represent a size-time-region-wide average for the Central American eruptions over the last 200 ka ensuring a comprehensive perspective. The simulations reveal global, long-lasting impact on the ozone layer affecting atmospheric composition and circulation for a decade. Column ozone drops below 220 DU (ozone hole conditions) in the tropics, Arctic and Antarctica, increasing biologically active UV by 80 to 400%. Our model results could potentially be validated using high-resolution proxies from ice cores and pollen records.
Electrophysiological correlates of the processing of different self-aspects of handwritten names
Authors: Sawada Reiko , Toichi Motomi , Masataka Nobuo 
Published: July 2019

AbstractHumans recognize the self in various visual domains, such as faces, names, and motions, as well as in products, such as handwritten letters. Previous studies have indicated that these various domains of self are represented differently in the brain, i.e., domain-specific self-representation. However, it remains unclear whether these differences in brain activation are due to the processing of different visual features or to differential self-processing among the domains, because the studies used different types of visual stimuli. The present study evaluated event-related potentials (ERPs) while participants were presented with their own and others’ names generated by the participants themselves or someone else. Therefore, the visual stimuli included two domains of self-related information, name and motor agent, but only one type of stimulus (handwritten names). The ERP results show that the amplitudes of the P250 component (250–330 ms) in the posterior regions were smaller for self-generated handwritten names than for non-self-generated handwritten names. The results also show that the amplitudes of the P300 component (350–500 ms) were larger for the self-name than for the non-self-name. These results suggest domain-specific processing of self-related information regarding the name and agent of handwritten stimuli.
Long-distance migratory shorebirds travel faster towards their breeding grounds, but fly faster post-breeding
Authors: Duijns Sjoerd , Anderson Alexandra M. , Aubry Yves , Dey Amanda , Flemming Scott A. , Francis Charles M. , Friis Christian , Gratto-Trevor Cheri , Hamilton Diana J. , Holberton Rebecca , Koch Stephanie , McKellar Ann E. , Mizrahi David , Morrissey Christy A. , Neima Sarah G. , Newstead David , Niles Larry , Nol Erica , Paquet Julie , Rausch Jennie , Tudor Lindsay , Turcotte Yves , Smith Paul A. 
Published: July 2019

AbstractLong-distance migrants are assumed to be more time-limited during the pre-breeding season compared to the post-breeding season. Although breeding-related time constraints may be absent post-breeding, additional factors such as predation risk could lead to time constraints that were previously underestimated. By using an automated radio telemetry system, we compared pre- and post-breeding movements of long-distance migrant shorebirds on a continent-wide scale. From 2014 to 2016, we deployed radio transmitters on 1,937 individuals of 4 shorebird species at 13 sites distributed across North America. Following theoretical predictions, all species migrated faster during the pre-breeding season, compared to the post-breeding season. These differences in migration speed between seasons were attributable primarily to longer stopover durations in the post-breeding season. In contrast, and counter to our expectations, all species had higher airspeeds during the post-breeding season, even after accounting for seasonal differences in wind. Arriving at the breeding grounds in good body condition is beneficial for survival and reproductive success and this energetic constraint might explain why airspeeds are not maximised in the pre-breeding season. We show that the higher airspeeds in the post-breeding season precede a wave of avian predators, which could suggest that migrant shorebirds show predation-minimizing behaviour during the post-breeding season. Our results reaffirm the important role of time constraints during northward migration and suggest that both energy and predation-risk constrain migratory behaviour during the post-breeding season.
Mitogenome types of two Lentinula edodes sensu lato populations in China
Authors: Song Xiaoxia , Zhao Yan , Song Chunyan , Chen Mingjie , Huang Jianchun , Bao Dapeng , Tan Qi , Yang Ruiheng 
Published: July 2019

AbstractChina has two populations of Lentinula edodes sensu lato as follows: L. edodes sensu stricto and an unexcavated morphological species respectively designated as A and B. In a previous study, we found that the nuclear types of the two populations are distinct and that both have two branches (A1, A2, B1 and B2) based on the internal transcribed spacer 2 (ITS2) sequence. In this paper, their mitogenome types were studied by resequencing 20 of the strains. The results show that the mitogenome type (mt) of ITS2-A1 was mt-A1, that of ITS2-A2 was mt-A2, and those of ITS2-B1 and ITS2-B2 were mt-B. The strains with heterozygous ITS2 types had one mitogenome type, and some strains possessed a recombinant mitogenome. This indicated that there may be frequent genetic exchanges between the two populations and both nuclear and mitochondrial markers were necessary to identify the strains of L. edodes sensu lato. In addition, by screening SNP diversity and comparing four complete mitogenomes among mt-A1, mt-A2 and mt-B, the cob, cox3, nad2, nad3, nad4, nad5, rps3 and rrnS genes could be used to identify mt-A and mt-B and that the cox1, nad1 and rrnL genes could be used to identify mt-A1, mt-A2 and mt-B.