bluuebunny/crossref_metadata_2025_split huggingface dataset:
High efficiency liposome fusion induced by reducing undesired membrane peptides interaction
Authors: Zheng Tingting , Chen Yun , Shi Yu , Feng Huanhuan 
Published: March 2019

AbstractA full membrane fusion model which attains both complete lipid mixing and content mixing liposomal membranes mediated by coiled-coil forming lipopeptidesLPK[L-PEG12-(KIAALKE)3] andLPE[L-PEG12-(EIAALEK)3] is presented. The electrostatic effects of lipid anchored peptides on fusion efficiency was investigated. For this, the original amino acid sequence of the membrane boundLPKwas varied at its ‘f’-position of the helical structure, i.e. via mutating the anionic glutamate residues by either neutral serines or cationic lysines. Both CD and fluorescence measurements showed that replacing the negatively charged glutamate did not significantly alter the peptide ability to form a coiled coil, but lipid mixing and content mixing assays showed more efficient liposome-liposome fusion resulting in almost quantitative content mixing for the lysine mutated analogue (LPKK) in conjunction withLPE. A mechanism is proposed for a fusion model triggered by membrane destabilizing effects mediated by the membrane destabilizing activety ofLPKin cooperation with the electrostatic activity ofLPE. This new insight may enlightens the further development of a promising nano carrier tool for biomedical applications.
Zagreb Connection Number Index of Nanotubes and Regular Hexagonal Lattice
Authors: Ye Ansheng , Qureshi Muhammad Imran , Fahad Asfand , Aslam Adnan , Jamil Muhammad Kamran , Zafar Asim , Irfan Rida 
Published: March 2019

AbstractTopological indices are the fixed numbers associated with the graphs. In recent years, mathematicians used indices to check the pharmacology characteristics and molecular behavior of medicines. In this article the first Zagreb connection number index is computed for the nanotubes VC5C7[ p, q] , HC5C7[ p,q] and Boron triangular Nanotubes. Also, the same index is computed for the Quadrilateral section $P_{m}^{n}$and $P_{m+\frac{1}{2}}^{n}$cuts from regular hexagonal lattices.
Specific, highly sensitive and simple spectrofluorimetric method for quantification of daclatasvir in HCV human plasma patients and in tablets dosage form
Authors: Ali Ramadan , Elsutohy Mohamed M 
Published: March 2019

AbstractA simple, selective and highly sensitive spectrofluorimetric method for the quantitative detection of an antiviral drug, daclatasvir (DCV) has been developed and analytically validated in its pure form, in its commercially available pharmaceutical preparations, and in hepatitis-C (HCV) patient’s plasma. The method was based on recording the native fluorescence of DCV that exhibit an emission wavelength maximum at 380 nm upon excitation at 320 nm. Many factors affecting the fluorescence intensity and the method sensitivity including pH, type of surfactant and solvent have been studied and optimized. In addition, a stability-indicating study was performed in accordance with the guidelines of the International Conference on Harmonization (ICH), to detect the drug in the presence of its degradation products which validates the method for application in quality control laboratories. In addition, extraction of DCV from the plasma proteins was performed using a simple technique that was based on using methanol and borate buffer (pH 9) that gave a recovery of ~95%. The results showed that DCV could be detected using this method in the pure form (with a linear range of 2-1000 ng/mL), commercially available tablets and in plasma samples (with a linear range of 5-1000 ng/mL), without any interferences. Furthermore, the method was also analytically and clinically validated according to the Food and Drug Administration (FDA) guidelines, with limit of detection (LOD) of 0.3 and 0.5 ng/mL for DCV in the pure form and plasma samples, respectively.
Critical Roles of the PI3K-Akt-mTOR Signaling Pathway in Apoptosis and Autophagy of Astrocytes Induced by Methamphetamine
Authors: Liu Han-Qing , An Ya-Wen , Hu A-Zhen , Li Ming-Hua , Wu Jue-Lian , Liu Li , Shi Yu , Cui Guang-Hui , Chen Yun 
Published: March 2019

AbstractThis study aimed to reveal potential roles of the phosphatidylinositol 3 kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway in apoptosis and autophagy of astrocytes induced by methamphetamine (METH). A Cell Counting Kit-8 (CCK-8) was used to determine the reduction in proliferation of U-118 MG cells induced by METH. Hoechst 33258 and flow cytometry were used to observe the astrocytes. Western blot analysis was performed to evaluate protein expression and phosphorylation levels. METH inhibited the proliferation of U-118 MG cells and induced apoptosis and autophagy. Western blot analysis showed that the ratio of LC3-II/I was increased, whereas the expression of Bcl-2 was decreased. The phosphorylation cascade of kinases in the PI3K-Akt-mTOR signaling pathway was significantly inhibited by METH exposure, as were proteins downstream of mTORC1, such as p70s6k, rps6, 4EBP1 and eIF4E. METH inhibited proliferation of U-118 MG cells and induced apoptosis and autophagy. The PI3K-Akt-mTOR signaling pathway likely plays a critical role in these effects.
GP and NCP
Authors: Hou Guojin , Jiang Qingsheng 
Published: March 2019

AbstractDespite its theoretical significance, Paul Grice’s CP, as the heart of classic and neo-Gricean pragmatics, has been a bone of contention for the last four decades for both Western and Eastern scholarship. This study addresses the contribution of four Chinese pragmaticians to the anti-CP principles: Guanlian Qian, Meizhen Liao, and Yameng Liu and Chunshen Zhu, focusing on the latter two. We briefly discuss Liao’s Goal Principle (GP) and Liu and Zhu’s Non-Cooperative Principle (NCP), which challenge Grice’s CP head-on. It points out that Liao’s GP is loaded with neo-Gricean pragmatic value as an alternative interpretation of CP but is not deemed “more applicable” as they claim, and that the NCP of Liu and Zhu, based on their CP query, sheds some light on neo-Gricean pragmatics and rhetoric, and yet calls for suspicion of their NCP as an “antistrophos/counterpart rhetoric-principle.” We maintain that cooperation in CP suggests pragma-philosophical cooperativeness or cooperationality between rational humans and that it applies to pragmatics and rhetoric alike, as well as to forensic, daily, and rhetorical utterances. It seems that so-called “non-cooperation in cooperation” or “cooperation in non-cooperation” is only logico-semantic non-cooperation, deeply rooted in the soil of pragma-philosophical cooperativeness or cooperationality.
______ is necessary for interpreting a proposition
Authors: Champagne Marc 
Published: March 2019

Abstract
In Natural propositions (2014), Stjernfelt contends that the interpretation of a proposition or dicisign requires the joint action of two kinds of signs. A proposition must contain a sign that conveys a general quality. This function can be served by a similarity-based icon or code-based symbol. In addition, a proposition must situate or apply this general quality, so that the predication can become liable of being true or false. This function is served by an index. Stjernfelt rightly considers the co-localization of these two parts to be a primitive phenomenon. Although this primitive character would seem to bar any further analysis, I endeavor to clarify the degree of proximity sufficient to enable co-localization. Siding with Pietarinen (2014), who argues that the whole issue should not be construed in metric terms, I conclude that one cannot make sense of propositional co-localization without appealing to some form of first-person perspective.
A Corpus-based Study of Metaphor inPavilion of Women
Authors: Zhao Xia , Han Yaoyao , Zhao Xincheng 
Published: March 2019

AbstractPavilion of Women, a vivid and interesting novel from the Nobel Prize winning author Pearl S. Buck, was selected as the corpus of the study. The goals of the research were to identify the metaphors, interpret their distributions in the novel, and construe Buck's metaphorical thoughts. To achieve these goals, the corpus tool Antconc3.2.4w was used to retrieve the keywords of the metaphors. The research results show that Buck uses many conceptual metaphors, and they are distributed in each chapter. Among them, the metaphors with the highest frequency appear in Chapter 7 and the lowest in Chapter 5, which shows that the more complicated and abstract the plot in a chapter, the more metaphors appear in it and vice versa. Meanwhile, structural metaphors appear the most frequently, followed by ontological metaphors, and finally the orientational metaphors. In addition, Pearl Buck’s cognitive context and her metaphorical thinking are found to have a close relationship with Chinese Yin-Yang semiotics and her own life experiences in China.
Of Thinkers and Tinkerers
Authors: Fernández Eliseo , Campbell Cary 
Published: March 2019

AbstractCary Campbell (ed.): This paper is one of four that were approved for publication in this journal prior to Fernández’s passing in 2017. Many of these backlogged articles did not have abstracts, so I have had to create them based on Fernández 's own in-text summary.In this brief presentation a crucial technological innovation of the early twentieth century – the invention of the triode thermionic valve – is used as a springboard for a historically informed discussion of the complex interrelations of theory and praxis in the generation of technological novelty. This episode was chosen for its critical role in triggering a whole chain of developments that culminated in the growing network of technologies and economic infrastructures that underpin our so-called “information society” and the evolving role of “technoscience.” This represents a starting point in a broadening cascade of innovations that led to the rise of television, digital computers and the expanding web of artifacts that shape our daily existence today. In the present era of technoscience, scientific and technological research are so closely entangled that it is hard to discern their respective natures and interrelations. Nevertheless, it is possible to partially distinguish both their common characteristics and their contrasting differences (i.e. in goals, cognitive styles, methods, etc.). In this context, some reflections are put forward on the activity of “tinkering” as a cognitive instrument (a form of what Peirce calledAbduction) in the generation of technological novelty.
Habit and Generalization
Authors: Fernández Eliseo , Campbell Cary 
Published: March 2019

Abstract
Both terms in our title, “habit” and “generalization,” are ordinary language expressions that take a peculiar and abstract sense in Peirce’s thought. From various standpoints, the concepts denoted by these two terms prove to be fundamental for understanding Peirce’s ideas, and eventually for the further development of these ideas in the philosophy of science. My review suggests that Peirce’s thought moves toward a goal that he constantly suggests but never articulates explicitly. This unstated objective is no other than the goal of generalizing the very idea of generalization. This article demonstrates that once the notion of habit is generalized, its connotational range swells to cover such diverse instances as those of symbol, rule, propensity, and law of nature. Therefore, this expanded conception can be applied to unify previously separated strands of thought and scientific practice. These considerations lead me to speculate on the possibility of extending Peircean synechism toward a wider conception that could include the generalizing functions of ideas concerning symmetry (and symmetry breaking) and other kinds of invariance.
A version of this paper was first presented at the conference “V Jornadas: Peirce en Argentina” at the Academia Nacional De Ciencias, De Buenos Aires, from August 23 to 24, 2012.
Development of Multistage Digital Filters for Dither Signal Removal in Ring Laser Gyro
Authors: Regimanu Bharath , Das Kishore Chandra , Rao Kakarla Subba 
Published: March 2019

Abstract
Ring Laser Gyroscopes (RLG) are widely used in Inertial Navigational Systems for detection of body rotation. But the performance is limited by lock- in state of RLG. To avoid this problem the Laser cavity of RLG is mechanically dithered. This process ensures that RLG stays out of the lock- in zone during its operating condition. But the dither signal appears as noise, which must be removed to obtain the true rotation of the body. This can be achieved by the use of digital filters. The required digital filter should have very high attenuation in the dither band and linear phase response in the pass band. Two types of multistage digital filters namely BBB and BCO filters are developed to remove the dither signal to an acceptable level. The BCO combined filter is found to be good and the same filter is implemented in real time using FPGA. The simulated results and the real time results are compared and found to be nearly same in both cases.
Failure conditions of solid wood on off-axis compression testing
Authors: Yoshihara Hiroshi 
Published: March 2019

Abstract
Off-axis compression tests (OACT) were conducted on solid wood from six tree species, and the relationship between the off-axis compressive strength (OACStr) and the off-axis angle was predicted under the conventional Hill-type quadratic failure conditions, off-axis special failure conditions, and under a condition proposed in this study, which contains terms of interaction between the normal and shear stresses. The latter was an effective approach for accurately predicting the OACStr, although the physical meaning of the interaction terms is not yet clear. Under the off-axis specialized conditions, the approach was simple and accurate for predicting the OACStr, which includes the 45° off-axis angle.
Isolation of natural flavoring compounds from cooperage woods by pressurized hot water extraction (PHWE)
Authors: Alarcón Marina , Díaz-Maroto M. Consuelo , Pérez-Coello M. Soledad , Alañón M. Elena 
Published: March 2019

AbstractCooperage woods are rich in volatile compounds responsible for pleasant aromas described as coconut, vanilla, spice, caramel, toasty, etc. In the present work, the hot water extraction under 103 bar pressure of natural flavoring compounds from cooperage wood residues is described. It was possible to obtain aqueous extracts rich in diverse volatile compounds from the following wood species: oak (Quercus albaandQuercus petraea), chestnut (Castanea sativa), cherry (Prunus avium), false acacia (Robinia pseudoacacia) and lenga (Nothofagus pumilio), while the concentration of the components is similar to that obtained with organic solvents. The gas chromatography-mass spectrometry (GC-MS) analysis of aqueous extracts shows a wide spectrum of natural flavoring compounds, the composition of which are species dependent. The extracts exhibit antioxidant properties. Water extraction under subcritical conditions offers the possibility of a sustainable recovery of natural flavorings and antioxidant compounds from cooperage woods, which are well suited for application in the food industry.
What’s the Buzz? Celebrity Worship and Fandom Experiences of Ted Neeley (Jesus Christ Superstar)
Authors: Roeland Johan , IJzerman Joren 
Published: March 2019

Abstract
This article deals with the question in what ways the fandom surrounding Jesus Christ Superstar actor Ted Neeley can be understood as a form of religious celebrity worship. On the basis of an empirical study among Dutch fans of Neeley, we argue that celebrity worship as proposed by the most influential scholars on this subject was not present in the fandom surrounding Neeley, but that traces of it could still be identified – albeit in a scattered and altered manner. Being perceived as the representation of the religious myth of Superstar, a Jesus-like person and a religious guide, Neeley had religious significance for his fans, suggesting that the concept of celebrity worship is in some way still applicable here.
Joining the Slow Pilgrimage in a Second Holy Week in Autumn: A Theopoetics from the Ars Moriendi.
Authors: Wepener Cas 
Published: March 2019

Abstract
The article is a response to Heather Walton’s IAPT presidential address titled “A Theopoetics of Practice – Re-forming in Practical Theology.” Practices examined in this article are rituals and caring related to death and dying in literature. By making use of Ronald Grimes’ so-called fictive ritual the portrayal of rituals and caring in novels by the Afrikaans novelist Karel Schoeman are examined. As a response to Walton’s address, a theopoetics is developed from the ars moriendi in the work of Schoeman.
Poetic License
Authors: Veling Terry A. 
Published: March 2019

Abstract
This paper is a response to Heather Walton’s 2017 Presidential Address to the International Academy of Practical Theology, “A Theopoetics of Practice – Re-forming in Practical Theology.” It explores a key question raised by Walton: “If we were to construct a way of imagining a theopoetics of practical theology, what would it look like?” The paper critiques systematic and speculative thinking, reflects on Holy Saturday, and offers a poetic reflection on creation and natural love.
Theopoetics as Response to Suffering: the Visual Art of Käthe Kollwitz in the Reformation of Practical Theodicy
Authors: Stoeber Michael 
Published: March 2019

Abstract
This article responds to Heather Walton’s impassioned call to form and reform practical theology via bricolage in the creative arts. It illustrates the epiphanic role of the visual art of Käthe Kollwitz (1867–1945) in transforming suffering. Following a brief outline of Kollwitz’s life, the paper explores the theopoetic power of her art in relation to practical theodicy: in terms of its social activist dynamics, deeply compassionate context, sanctifying and consoling powers, and numinous-mystical affections.
A Theopoetics of Practice: Re-forming in Practical Theology
Authors: Walton Heather 
Published: March 2019

Abstract
This article articulates a challenge to discern what form theopoetics might take within practical theology and, further, to engage with the construction of modes of theopoetic making appropriate to the discipline. To date there has been little conceptual engagement with theopoetics by practical theologians. In order to begin to address this lack Catherine Keller’s work is taken as indicative of the potential significance of this project. An examination of theopoetics within constructive theology highlights the necessity for practical theologians to create their own distinctive forms of theopoetical reflection honouring their disciplinary heritage. It is suggested that a ‘theopoetics of practice’ might be created in the manner of a bricolage from neglected cultural resources. The work embodies in its writing style the creative work it advocates.
Practical Theology in Africa: Situation, Approaches, Framework and Agenda Proposition
Authors: Magezi Vhumani 
Published: March 2019

Abstract
Practical Theology’s situation in Sub-Saharan Africa is not well documented except in South Africa, despite a strong theological focus on practical ministry across the continent and considerable discussion of African contextual theologies, including African theology, Black theology, reconstruction theology and women’s theology. The article sketches the context by highlighting the gaps in the discussion of Practical Theology. It discusses embedded Practical Theological practices within contextual theologies and surveys Practical Theology’s focus and aspirations across Africa, highlighting practices in Anglophone Africa, Francophone Africa and Lusophone Africa. Finally, it deduces a framework for Practical Theology in Africa and identifies the challenges and tasks that should be put on the agenda of Practical Theology.
Factors Affecting ICT Use in Health Communication among the Older Population in Jiangsu, China
Authors: Zhang Yao , Lin Zhenping , Li Xiaoming , Xiaoming Tu , Zhou Yeqin , Zhang Xinping 
Published: March 2019

AbstractWe examined the status of information communication technology (ICT) use among the older population in China and investigated their use of ICT in health communication and the factors that impacted their ICT adoption. A total of 215 people who were 45 or older participated in the study. A questionnaire survey was conducted to collect data on the participants’ social demographic characteristics, health condition, ICT use and ICT-based health communication activities. The data were analyzed using Chi-square test, one-way ANOVA, univariate logistic regression and multiple logistic regression. The results showed that 38.1 % of the participants reported being in a good health while 14.9 % were living with no chronic disease. The utilization of ICT was low, especially for computer and digital monitor devices. Only 4.7 % of the participants reported seeking health information online via computer and 7.4 % seeking health information using their cellphone, while 32 % and 14.9 % of the participants contacted healthcare providers or other patients via cellphone. Findings suggest a digital divide exists between the older population and other age groups in China. The older population need to increase the use of digital monitor devices and other ICT to facilitate their self-management process for healthcare purposes. eHealth literacy should be promoted among the older population to increase the adoption and use of ICT in health communication. Future intervention program developers and service providers should tailor their products and services to benefit the older population, especially those with low incomes, limited education and little experience of using ICT.
Long-standing issues in adjective order and corpus evidence for a multifactorial approach
Authors: Trotzke Andreas , Wittenberg Eva 
Published: March 2019

AbstractIn this paper, we introduce the issue of adjective order and show that different approaches vary in their answers to the question of how fine-grained the semantic categories determining adjective order are. We report on a corpus study that we conducted and that illustrates that a clear answer to the question of what general factors exactly determine adjective order is elusive, given the multifactorial nature of the problem. We then present the individual contributions to this special issue, and how they attempt to add new observations from Germanic languages to the general issues revolving around the topic of adjective order.
Adjective orders in Cimbrian DPs
Authors: Bidese Ermenegildo , Padovan Andrea , Turolla Claudia 
Published: March 2019

AbstractIn this work we aim to give a first description of the morphosyntactic behavior of some adjectives in the Cimbrian of Luserna. This Germanic variety allows a subclass of adjectives to appear in post-nominal position. This aspect seems to be relevant, since neither colloquial Standard German nor any other German substandard variety spoken in German-speaking areas display a similar pattern. Along the lines of Cinque (2010, 2014), we argue that Cimbrian, with respect to the adnominal adjectival order, has maintained the Germanic pattern of Merge, but permits in some cases NP-Movement above the (“bare” AP reduced) relative clause projection. The fact that adjectives following the head noun are predicative rather than attributive is supported by the fact that post-nominal modifiers never show up with inflection.