bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of medical and surgical treatment on the risk of major adverse cardiovascular and cerebrovascular events in Asian women with endometriosis
Authors: Chiang Hsin-Ju , Lan Kuo-Chung , Yang Yao-Hsu , Chiang John Y. , Kung Fu-Tsai , Huang Fu-Jen , Lin Yu-Ju , Su Yu-Ting , Sung Pei-Hsun 
Published: October 2019

Abstract
Background: Endometriosis (EM) is linked to cardiovascular disease (CVD). However, whether this finding can be applied to the Asian population remained unanswered. Results are still conflicting in terms of therapeutic effect on the risk of CVD in patients with EM. Therefore, we investigated the association between EM and major adverse cardiovascular and cerebrovascular events (MACCE) and the therapeutic effect on the risk of MACCE in Asian women with EM. Methods: The Taiwan National Health Insurance Research Database was used for this retrospective population-based cohort study from 1997 to 2013. A total of 17 543 patients with EM aged between 18 and 50 years were identified from a general population of 1 million after excluding diagnoses of major CVD and cerebrovascular accident (CVA) prior to EM. The comparison group (n = 70 172) without EM was selected by matching the study cohort with age, sex, and income and urbanization levels in a 4:1 ratio. Demographic data and the frequency of comorbidities between groups were compared using the independent t test and chi-square test. The incidence and risk of MACCE were analyzed using the log-rank test and a multivariate Cox proportional hazards model. Results: During a median follow-up period of 9.2 years, Asian women with EM had a significantly higher frequency of comorbidities, medical and surgical treatment, and MACCE than did their non-EM counterparts (2.76% vs 2.18%, P < .0001). After adjustment for comorbidities, patients with EM had an approximately 1.2-fold increased risk of MACCE (95% CI 1.05-1.29; P = .0053) and a higher cumulative incidence of MACCE compared with the normal population. Among women with EM, neither medical nor surgical treatment increased the risk of MACCE, including major CVD and CVA. Furthermore, medical treatment for EM appeared to be protective against MACCE. Conclusion: Asian women with EM not only had a substantially higher frequency of comorbidities but also an increased risk of MACCE compared with the general population. In terms of medical or surgical treatment of EM, the safety concern regarding MACCE was not evident.
Sufficient Tissue Acquisition Rate of Peroral Cholangioscopy-guided Forceps Biopsy
Authors: Onoyama Takumi , Takeda Yohei , Kawata Soichiro , Kurumi Hiroki , Koda Hiroki , Yamashita Taro , Hamamoto Wataru , Sakamoto Yuri , Matsumoto Kazuya , Isomoto Hajime 
Published: October 2019

Abstract
Background: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficient amount of specimen at times. Aims: We evaluated the sufficient tissue acquisition rate and the factors affecting the sufficient tissue acquisition of POCS-guided forceps biopsy for the biliary tract. Methods: Patients who underwent POCS-guided forceps biopsy for biliary disease between September 2016 and October 2018 at our hospital were enrolled retrospectively. We evaluated the sufficient tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion and that for non-stenotic bile duct. In addition, the factors affecting the sufficient tissue acquisition rate of POCS-guided forceps biopsy were evaluated. Results and Conclusions : We enrolled 47 patients with the biliary disease and performed POCS-guided forceps biopsy for biliary lesion and POCS-guided forceps mapping biopsy for non-stenotic bile duct in 40 and 36 patients, respectively. The sufficient tissue acquisition rates of POCS-guided forceps biopsy for biliary lesions and that for non-stenotic bile duct were 86.4%, and 68.9%, respectively. In the multivariate logistic regression analyses, age and previous biliary stenting before POCS were factors affecting the sufficient tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. For non-stenotic bile duct, the location of the biliary lesion, endoscopic sphincterotomy, and procedure time of POCS were factors affecting the sufficient tissue acquisition rate of POCS-guided forceps mapping biopsy.
The risk factors for post-polypectomy bleeding and establishment of a risk-scoring model for small colorectal polyps (&lt;1.5cm) in an ambulatory surgery center: a retrospective analysis
Authors: Lei Tiantian , Yan Hailin , Lu Qing , Wang Yilan , Ma Hongsheng , Yang Jinlin 
Published: October 2019

Abstract
Background: As one of the most common complications of colonoscopy, the risk factors of post-polypectomy bleeding (PPB) has been rarely explored in an ambulatory surgery unit. We aim to develop a risk-scoring model to predict the risk of PPB forsmall colorectal polyps (<1.5cm) in an ambulatory surgery unit. Methods: The patients with single small colorectal polyps (<1.5cm) who underwent endoscopic polypectomy in the Ambulatory Surgery Center of our hospital between January 2014 and June 2017 were included and retrospectively reviewed. We analyzed patient’s clinical characteristics, morphological and pathological characteristics of polyps, polypectomy techniques, and the occurrence of PPB. Risk factors of PPB were identified with a multivariable logistic regression model. In addition, a risk-scoring system was developed and validated eventually. Results: Among the 771 patients enrolled, 26 (3.4%) patients suffered PPB. The male gender, elderly age (≥ 60 years), using hot biopsy forceps as polypectomy technique adenoma in histopathology, complicated withhypertension, use of anticoagulant or antiplatelet agents, and early excessive activities significantly increased the risk of PPB (P＜0.05) as indicated by the results of multivariable logistic regression analysis. The area under the ROC curve (AUC) in the model group (0.890) and validation group (0.924) indicated that the risk-scoring model could predict the occurrence of PPB effectively. Conclusions: This risk-scoring method may help to predict the risk of PPB forsmall colorectal polyps, fit well in the Ambulatory Surgery Center, and provide a new approach to help reduce the incidence of hemorrhage after colorectal polypectomy.Trial registration: This study was retrospectively registered and approved by the Ethics Committee of West China Hospital of Sichuan University (IRB number: ChiCTR1800020201).
Do the human gut metagenomic species possess the minimal set of core functionalities necessary for life?
Authors: Soverini Matteo , Rampelli Simone , Turroni Silvia , Brigidi Patrizia , Biagi Elena , Candela Marco 
Published: October 2019

Abstract
Background.
Advances in bioinformatics recently allowed for the recovery of ‘metagenomes assembled genomes’ from human microbiome studies carried on with shot-gut sequencing techniques. Such approach has been proposed as a mean to discover new so-called ‘uncultured metagenomic species’.
Results.
In the present analysis we compare 400 genomes from isolates available on NCBI database and 400 human gut metagenomic species, screening all of them for the presence of a minimal set of core functionalities necessary, but not sufficient, for life. Even if a genome completeness up to 96% is reported in the original study, the metagenomic species resulted substantially depleted in genes encoding for essential functions to support autonomous bacterial life, with the 16S rRNA gene missing in 237 out of the 400 metagenomic species we analyzed.
Conclusions.
The relevant degree of lacking core functionalities that we observed in metagenomic species raises some concerns about the effective completeness of metagenome-assembled genomes, suggesting caution in extrapolating information about their metabolic propensity and ecological role in the human gastrointestinal tract.
Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
Authors: Wang Wei , Ren Gang , Hong Ni , Jin Wenfei 
Published: October 2019

Abstract
Background: CCCTC-Binding Factor (CTCF), also known as 11-zinc finger protein, participates in many cellular processes, including insulator activity, transcriptional regulation and organization of chromatin architecture. Based on single cell flow cytometry and single cell RNA-FISH analyses, our previous study showed that deletion of CTCF binding site led to a significantly increase of cellular variation of its target gene. However, the effect of CTCF on genome-wide landscape of cell-to-cell variation is unclear.
Results: We knocked down CTCF in EL4 cells using shRNA, and conducted single cell RNA-seq on both wild type (WT) cells and CTCF-Knockdown (CTCF-KD) cells using Fluidigm C1 system. Principal component analysis of single cell RNA-seq data showed that WT and CTCF-KD cells concentrated in two different clusters on PC1, indicating gene expression profiles of WT and CTCF-KD cells were systematically different. Interestingly, GO terms including regulation of transcription, DNA binding, Zinc finger and transcription factor binding were significantly enriched in CTCF-KD-specific highly variable genes, indicating tissue-specific genes such as transcription factors were highly sensitive to CTCF level. The dysregulation of transcription factors potentially explain why knockdown of CTCF lead to systematic change of gene expression. In contrast, housekeeping genes such as rRNA processing, DNA repair and tRNA processing were significantly enriched in WT-specific highly variable genes, potentially due to a higher cellular variation of cell activity in WT cells compared to CTCF-KD cells. We further found cellular variation-increased genes were significantly enriched in down-regulated genes, indicating CTCF knockdown simultaneously reduced the expression levels and increased the expression noise of its regulated genes.
Conclusions: To our knowledge, this is the first attempt to explore genome-wide landscape of cellular variation after CTCF knockdown. Our study not only advances our understanding of CTCF function in maintaining gene expression and reducing expression noise, but also provides a framework for examining gene function.
Joint Modelling of Colorectal Cancer Recurrence and Death after resection using Multi-State Model with Cured Fraction
Authors: Alafchi Behnaz , Roshanaei Ghodratollah , Tapak Leili , Abasi Mohammad , Mahjub Hossein 
Published: October 2019

Abstract
Background Curing of colorectal cancer (CRC) occurs at the time of resection, but it is not immediately observable. If the cancer is not completely eliminated, the patient will not be cured of cancer and will experience a recurrence as the tumor has regrown to a detectable size. The main proposes of the present study was to assess the effects of different covariates on the probability of being cured as well as the time to recurrence, time to death, and time to death after recurrence in CRC patients by using multi-state cure model.Methods In the present study, the information of 283 patients with adenocarcinoma CRC, who underwent resection, from 1992 to 2015 in Imam Khomeini Hospital of Hamadan, Iran, were analyzed. A multi-state cure model is used to joint modeling the recurrence and death in patients with CRC when a fraction of patients was apparently cured after resection.Results The results revealed that females, patients diagnosed at stage IV and whom underwent radiotherapy were less likely to be apparently cured. Also, more than 50% of not cured patients recurred later. Moreover, the survival time of patients was affected by the stage of disease, age at diagnosis and receiving radiation therapy. In addition, sex had a significant effect on the time-to-recurrence.Conclusions The multi-state cure model provided a flexible framework to study and compare the effects of prognostic factors simultaneously on the transition between different health states and the probability of being apparently cured of CRC.
Clinical and Prognostic Value of 18F-FDG-PET/CT in the Restaging Process of Recurrent Cutaneous Melanoma
Authors: Albano Domenico , Familiari Demetrio , Fornito Maria C. , Scalisi Salvatore , Laudicella Riccardo , Galia Massimo , Grassedonio Emanuele , Ruggeri Antonella , Ganduscio Gloria , Messina Marco , Spada Massimiliano , Midiri Massimo , Alongi Pierpaolo 
Published: October 2019

Background:
Several studies on 18F-FDG-PET/CT have investigated the prognostic role of
this imaging modality in different tumors after treatment. Nevertheless, its role in restaging patients
with recurrent CM still needs to be defined.

Objective:
The aim of this retrospective multicenter study was to evaluate the clinical and prognostic
impact of 18F-FDG-PET/CT on the restaging process of cutaneous melanoma (CM) after surgery in
patients with suspected distant recurrent disease or suspected metastatic progression disease.

Materials and Methods:
74 patients surgically treated for CM underwent 18F-FDG-PET/CT for suspected
distant recurrent disease or suspected metastatic progression disease. The diagnostic accuracy of
visually interpreted 18F-FDG-PET/CT was obtained by considering histology (n=21 patients), other
diagnostic imaging modalities performed within 2 months of PET/CT (CT in 52/74 patients and
Whole-Body MRI in 18/74 patients) and clinical follow-up (n=74 patients) for at least 24 months containing
all the clinical and diagnostic information useful for the PET performance assessment and outcome.
Progression-free survival (PFS) and overall survival (OS) were assessed by using the Kaplan-
Meier method. The risk of progression (Hazard Ratio-HR) was computed by the Cox regression analysis.

Results:
Suspicion of recurrent CM was confirmed in 24/27 patients with a positive 18F-FDG-PET/CT
scan. Overall, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy
of 18F-FDG-PET/CT were 82%, 93%, 88%, 89%, and 89%, respectively, with area under the
curve being 0.87 (95%IC 0.78-0.97; p<0.05). 18F-FDG-PET/CT findings significantly influenced the
therapeutic management in 18 patients (modifying therapy in 10 patients; guiding surgery in 8 patients).
After 2 years of follow-up, PFS was significantly longer in patients with a negative vs. a positive
18F-FDG-PET/CT scan (90% vs 46%, p<0.05; Fig. 1). Moreover, a negative scan was associated
with a significantly longer OS than a positive one (76% vs 39% after 2 years, p<0.05; Fig. 2). In addition,
a positive 18F-FDG-PET/CT scan was associated with an increased risk of disease progression
(HR=8.2; p0,05).

Conclusion:
18F-FDG-PET/CT showed a valuable diagnostic performance in patients with suspicion of
recurrent CM. This imaging modality might have an important prognostic value in predicting the survival
outcomes, assessing the risk of disease progression, and guiding treatment decision making.
Connected Health User Willingness to Share Personal Health Data: Questionnaire Study
Authors: Karampela Maria , Ouhbi Sofia , Isomursu Minna 
Published: October 2019

Background
Connected health has created opportunities for leveraging health data to deliver preventive and personalized health care services. The increasing number of personal devices and advances in measurement technologies contribute to an exponential growth in digital health data. The practices for sharing data across the health ecosystem are evolving as there are more opportunities for using such data to deliver responsive health services.

Objective
The objective of this study was to explore user attitudes toward sharing personal health data (PHD). The study was executed within the first year after the implementation of the new General Data Protection Regulation (GDPR) legal framework.

Methods
The authors analyzed the results of an online questionnaire survey to explore the willingness of 8004 people using connected health services across four European countries to share their PHD and the conditions under which they would be willing to do so.

Results
Our findings indicate that the majority of users are willing to share their personal PHD for scientific research (1811/8004, 22.63%). Age, education level, and occupation of the participants, in addition to the level of digitalization in their country were found to be associated with data sharing attitudes.

Conclusions
Positive attitudes toward data sharing for scientific research can be perceived as an indication of trust established between users and academia. Nevertheless, the interpretation of data sharing attitudes is a complex process, related to and influenced by various factors.
Efikasi Misoprostol Rektal Intraoperasi Seksio Cesarea Versus Oksitosin dalam Mengurangi Jumlah Perdarahan untuk Mencegah Perdarahan Post Partum
Authors: Milhan Milhan , Soejoenoes Ariawan , Prawitasari Shinta 
Published: October 2019

Latar Belakang : Perdarahan post partum adalah salah satu etiologi kematian ibu. Setelah operasi caesar, uterotonik dalam bentuk infus oksitosin (20-40 IU) atau misoprostol rektal (200-600 μg) diberikan untuk kontraksi uterus pasca operasi pada pasien pada risiko perdarahan post partum. Penelitian ini dibuat membandingkan kedua agen uterotonik tersebut.Tujuan : Mengetahui perbandingan penggunaan misoprostol rektal tiga tablet (600 ugr) dan penggunaan oksitosin 20 IU selama operasi seksio cesarea dalam mengurangi jumlah perdarahan untuk mencegah perdarahan post partum di fasilitas kesehatan tingkat lanjut.Metode : Penelitian ini adalah double blind randomised controlled trial. Populasi penelitian adalah pasien rawat inap ruang kebidanan dan kandungan RSUD Datu Sanggul, Rantau. Besar sampel ditentukan dengan rumus Kirkwood dan Steme sebesar 98. Secara acak peserta dibagi ke kelompok misoprostol dan oksitosin. Farmasi menyediakan obat penelitian dan plasebo dalam bentuk yang tidak dapat dikenali. Untuk kelompok misoprostol disiapkan tablet misoprostol 600 μg untuk digunakan secara rektal ditambah spuit yang sudah diisi sebelumnya larutan saline normal. Kelompok oksitosin disiapkan tablet plasebo untuk digunakan secara rektal ditambah jarum suntik dengan oksitosin 20 IU dan larutan normal saline.Hasil dan Pembahasan: Didapatkan kelompok 1 (misoprostol) dari 42 sampel, yang mengalami perdarahan kurang dari 1000 ml sebanyak 41 sampel (97,6%) dan yang perdarahan lebih dari atau sama dengan 1000 ml sebanyak 1 sampel (2,38%). Sedangkan kelompok 2 (oksitosin) dari 42 sampel yang mengalami perdarahan kurang dari 1000 ml sebanyak 36 sampel (85,7% ) dan yang perdarahan lebih dari 1000 ml sebanyak 6 sampel (14,3% )Kesimpulan: Ada perbedaan bermakna antara jumlah perdarahan kelompok misoprostol dengan jumlah perdarahan kelompok oksitosin. Karena mean rank kelompok misoprostol lebih rendah dapat disimpulkan bahwa: “Jumlah perdarahan pada penggunaan misoprostol rektal tiga tablet (600 ugr) lebih sedikit dibanding penggunaan oksitosin 20 IU selama operasi seksio cesarea”. Di antara variabel-variabel perancu, riwayat partus lama dan adanya faktor keterlambatan, berhubungan dengan jumlah perdarahan. Variabel yang dapat digunakan untuk memprediksi jumlah atau banyaknya perdarahan adalah variabel “ada terlambat/tidak”. Kata Kunci: Jumlah Perdarahan, Oksitosin, Misoprostol, Perdarahan Postpartum
On the Question of Choice of Software Tools for Modeling Radio Systems
Authors: Raev A. S. , Kopysov A. N. , Khvorenkov V. V. 
Published: October 2019

Ключевым трендом современных радиотехнических систем является переход к цифровым технологиям. Особенно ярко это выражено в процессе развития и широкого внедрения технологии программно-определяемых радиосистем, или иначе software-defined radio(SDR). В результате формирования данной технологии появилась возможность разработки современных радиолокационных систем, используя программные модели, базирующиеся на технологии SDR .В работе рассматривается вопрос выбора разработчиком программных инструментов для моделирования и проектирования радиолокационных систем. Для ответа на данный вопрос выполняется оценка двух сред программирования SDR-систем – Lab VIEW и GNU Radio, производится их общие описание. Рассматриваются их структуры, модели основных компонентов, интерфейсов, а также системы программного обеспечения и системные требования.Приведены примеры использования инструментов в исследовании радиолокационных систем на основе сигнала с линейной частотной модуляцией. На основе алгоритма генерации такого сигнала разработаны модели генераторов и проведена оценка работы исследуемых сред программирования SDR. Построены графики генерируемого сигнала с выбранными параметрами как во временной, так и в частотной областях. В процессе работы и конфигурации примеров проведен анализ вычислительных возможностей и временных затрат, сопряженных с работой оцениваемых сред программирования SDR.Сформулированы основные достоинства; к их числу относятся универсальность и доступность, а также недостатки, включающие затраты времени на программирование и отсутствие гибкости проектов, описанных оболочек, проведено их сравнение в совокупности между собой.
Ethnopharmacy Study of Suku Anak Dalam (SAD) in Muara Kilis Village, Tengah Ilir, Tebo District, Jambi Province
Authors: Perawati Santi , Andriani Lili , Anggresani Lia , Ardila Eti 
Published: October 2019

ABSTRACT
Background: Indonesia consists of various ethnics on each island, one of which is Suku Anak Dalam (SAD) precisely on Sumatra island of Jambi Province. Each ethnic group has a variety of natural and traditional remedies. This observation was conducted from November 2017 to February 2018 in Muara Kilis Village, Tengah Ilir District, Tebo District, Jambi Province.This research purpose to determined of various disease and know the various natural resources that are used as a treatmenton Suku Anak Dalam at Muara Kilis. Method: This research type is descriptive research using qualitative method and purposive sampling for sampling technique and open-ended interview with informant using voice recording media. Results: The disease are often experienced by Suku Anak Dalam among others fever, cough, asthma, measles, gastritis, hemorrhoids, stomachaches, and allergy. To treat the disease by utilizing natural resources like plants and animals. Part of the plants used among others, leaves, sap, and fruit, while for animal parts used are bile, urine, and blood. Processing methods are pounded, boiled, grated, and fried, while the use of these ingredients by eating, drinking, bathed, and applied directly on part of sickness skin Conclusion: Based on the results that has been done there are 8 diseases that often occur and there are 5 kinds of plants and 4 animals from different genus and family that are used as traditional medicine in Suku Anak Dalam Muara Kilis Village.

Keywords: (Ethnopharmacy, Suku Anak Dalam, Diseases, Natural Resources)