bluuebunny/crossref_metadata_2025_split huggingface dataset:
Easy, Rapid and High‐Throughput Production of Single and Multicompartment Liposomes by Vortex Emulsification
Authors: Luo Zhen‐Hong , Shi Gong‐Yu , Deng Nan‐Nan 
Published: November 2024

AbstractCell‐sized liposomes, the self‐assembled phospholipid vesicles with bilayer membranes, have garnered substantial attention across various fields, particularly as cell mimics. In this study, we introduce a simplified method for rapidly producing single‐ and multicompartment liposomes using a common laboratory vortex mixer. The simplicity of our method has the potential to greatly facilitate artificial cell and tissue‐related research, potentially leading to broader applications of liposomes.
Numerical Investigation and Cross‐Section Type Selection of Concrete‐Filled Double Steel Plate (CFDSP) Composite Shear Walls Under Cyclic Loading
Authors: Cobanoglu Omer , Ni Xiangyong , Zhao Bin 
Published: November 2024

ABSTRACTConcrete‐filled double steel plate (CFDSP) composite shear walls have excellent seismic performance and are generally used as lateral resistance for high‐rise buildings. However, the numerical simulation of such walls is complicated because of the complex contact between the concrete, the external steel plate, and the shear studs. Eighteen CFDSP walls in the present literature were numerically simulated under cyclic and constant axial loading, and the accuracy was evaluated by comparing them with the experimental results. Then, the impact of cross‐section variations on the structural performance of CFDSP walls under the same steel content ratio was numerically investigated. Designed numerical walls were evaluated under the same loading conditions with four distinct cross‐sections for comparative analysis. Finally, parametric analysis was performed to observe the influence of aspect ratio, steel thickness, and stud spacing on the seismic performance of CFDSP walls. The analysis results show that the proposed numerical model can accurately recover the hysteretic curves of CFDSP walls regarding strength reduction, energy dissipation, and pinch behavior.
Considerations for the Design of Pedagogical Tasks in Computer‐Based L2 Listening
Authors: Cárdenas‐Claros Mónica S. , Dassonvalle Kimberley , Rodríguez‐Arias Paula , Cáceres‐Ramírez Belén 
Published: November 2024

AbstractThis multi‐stage study introduces a comprehensive set of considerations to inform task design for pedagogical purposes in computer‐based L2 listening environments. Using a 360‐degree approach to consideration construction and validation, which included bottom‐up and top‐down perspectives, this study engaged participants with diverse backgrounds in language learning, language teaching, and research, and employed varied data collection and data analysis procedures. During the initial stage, we used educational engineering techniques to elicit personal goals from 68 high school learners of English. In Stage 2, we undertook a participatory action research cycle involving pre‐service and in‐service language teachers to construct guidelines based on the data analysis and results from Stage 1. Finally, in Stage 3, we refined and validated those guidelines and devised a final set of eight considerations with the input of L2 listening and CALL experts. We conclude this paper by presenting the final set of eight considerations to the community and encourage implementation in diverse language teaching contexts.
Presence of Microplastics in Water, Soil, Organic Fertilizer, and Potato Plants on Potato Plantations
Authors: Setyobudi Roy Hendroko , Iswahyudi Iswahyudi , Damat Damat , Garfansa Marchel Putra , Hermayanti Diah , Ramadani Shefa Dwijayanti , Vincevica‐Gaile Zane , Nurfadilah Lira Rizqi , Savitri Evika Sandi , Meylanzharie Zhulvie 
Published: November 2024

ABSTRACTMicroplastics (MPs) have become a significant environmental concern, but data on their presence in potato gardens are limited. This study aims to identify and quantify MPs in soil, organic fertilizer, irrigation water, and potato plants in potato gardens. Soil, fertilizer, irrigation water, and potato samples were collected from potato fields. Analysis was carried out using a microscope and Fourier transform infrared spectroscopy (FTIR) to identify the shape, color, quantity, and type of MP polymer. The results indicate significant MPs contamination with the most dominant shape of fibers (86%) and fragments (8%), dominant color black (35%) and blue (27%), abundances of MPs 0.10–9.20 g−1, as well as the presence of polyethylene terephthalate (PET) and high‐density polyethylene (HDPE) polymers. These MPs have the potential to harm plant growth and soil quality. MPs are found in significant quantities in potato gardens and have the potential to disrupt agricultural ecosystems. The presence of MPs in potato gardens can affect the quality of agricultural products and human health throughout the food chain.
Assessment of Groundwater Quality and Fluoride Contamination in Dharmapuri and Krishnagiri Districts, Tamil Nadu, India
Authors: Kavisri M. , Moovendhan Meivelu 
Published: November 2024

ABSTRACTFluoride is highly threatening to human health, and it is a serious issue worldwide, especially in India, because several states in India are at high risk of fluoride contamination in drinking water. In this study, the groundwater from Dharmapuri and Krishnagiri districts was chosen for estimation of quality and fluoride level. The 20 samples were collecetd from two districts, water quality and fluoride were estimated using standard protocols. The results showed that in Dharmapur districts, including Dharmapuri and Morappur, the water quality was very poor and the water was in bad condition, and also the water quality and fluoride levels were above the acceptable limits of WHO and TWAD board norms. In Krishnagiri district, such as Hosur, and Larger domestic water samples were highly polluted. The Pochampalli and Hangar, Anjetti, and area ground waters were in poor condition, the rest of the area's water quality and fluoride level are moderate, and may increase in the upcoming years. The quality of water and fluoride levels have crossed the permissible limits of WHO and TWAD board standards in several sites of Krishnagiri and Dharmapuri districts. Frequent monitoring, more awareness programs, fluoride removal advanced eco‐friendly, and highly efficient technologies are needed to manage these pollutants issues.
Frühe Hilfen im deutschsprachigen Raum – unterschiedliche Wege zum gleichen Ziel
Authors: Weigl Marion , Haas Sabine 
Published: November 2024

ZusammenfassungUnter „Frühen Hilfen“ wird im deutschsprachigen Raum grundsätzlich ein Gesamtkonzept von Maßnahmen zur Gesundheitsförderung und insbesondere gezielten Frühintervention in Schwangerschaft und früher Kindheit verstanden, das sich vor allem an Familien in belastenden Lebenssituationen richtet. Dieser Artikel bietet einen Überblick über die Frühen Hilfen in Deutschland, Österreich, Schweiz, Liechtenstein und Südtirol.Während in Deutschland verschiedene Modelle in die Umsetzung gelangt sind und bis heute noch nebeneinander fortbestehen, wurde in Österreich ein einheitliches Modell festgeschrieben. An diesem orientieren sich auch Südtirol und Liechtenstein. Für die Schweiz liegt zwar mittlerweile auch ein Konzept vor, die Umsetzung erfolgt jedoch bislang nur in einzelnen Kantonen. Eine rechtliche Verankerung gibt es bis dato in Deutschland, Österreich und Südtirol. In Deutschland, Österreich und Liechtenstein wurde jeweils ein nationales Zentrum zur laufenden fachlich-wissenschaftlichen Begleitung und Qualitätsentwicklung beauftragt. Auf Ebene der Bundesländer (Deutschland und Österreich) bzw. der Regionen (Südtirol) sind koordinierende Einheiten aktiv, die jedoch teilweise unterschiedliche Aufgaben innehaben. Das Kernelement der freiwilligen, kostenlosen und aufsuchenden Familienbegleitung erfolgt nach dem österreichischen Modell durch ein multiprofessionelles Team, in Deutschland durch definierte Berufsgruppen (Familienhebammen und Familien-Gesundheits- und Kinderkrankenpflegende). Die verfügbaren Daten sowie Ergebnisse aus der Begleitforschung zeigen, dass die Frühen Hilfen ihr Ziel erreichen. Familien werden entlastet, es werden Zugänge zu spezifischen Unterstützungsangeboten erleichtert. Als sozial bzw. sozioökonomisch benachteiligt geltende Familien können großteils gut erreicht werden.
Effects of drugs on the oxygen dissociation curve—a scoping review
Authors: Haller Thomas , Lesser Lukas , Woyke Simon 
Published: November 2024

Abstract
Purpose
The shape and position of the hemoglobin-oxygen dissociation curve (ODC) is of critical importance in medicine, as it determines the uptake of O2 in the lungs and the delivery of O2 to the tissues. Numerous reports have identified affinity-modulating effects of drugs in humans. Such effects may be relevant to conditions such as pulmonary diffusion disorders, peripheral vascular disease, or coronary artery disease. The aim of this scoping review was to assess and summarize the current evidence on these effects.

Methods
The review was based on the PRISMA-ScR guidelines. We searched PubMed and the Cochrane Library and only included papers with free full-text access. The search covers all papers published before September 2024 and used the following keywords: “Oxygen affinity” or “oxygen dissociation curve” in combination with > 100 substance classes that should cover most drugs in clinical use.

Results
The search returned 2447 hits of which 80 were selected for further full text review. In terms of discipline, cardiology accounted for the largest proportion, and in terms of effect quality, a right-ward shift resulting in improved tissue oxygenation was most common. For example, quantitative data show an increase in P50 of 6.1–12.4% and 25–53% for propranolol and RSR13, respectively.

Conclusion
Despite a substantial body of data, the effects of the vast majority of drugs on the ODC have not been studied or have not been studied in sufficient detail. The undeniable potential for medical interventions to alter the ODC calls for revival of this area of research.
Analysis of the effects of fiber positioning on water transfer in hollow fiber humidifiers using cfd and statistical uniformity metrics
Authors: Pollak Markus , Tegethoff Wilhelm , Koehler Juergen 
Published: November 2024

Abstract
Hollow fiber membrane humidifiers are used in mobile proton exchange membrane (PEM) fuel cell systems to humidify the supply air of the fuel cell and thereby to achieve a sufficient level of humidification of the PEM. A hollow fiber humidifier contains a large amount of hollow fiber membrane that transfers water from the moisture-laden exhaust gas of the fuel cell to the dry supply air along a concentration gradient. In this study, the effect of fiber placement on the water transfer inside hollow fiber bundles is investigated in detail using a validated CFD model of a membrane humidifier. To analyze the effects of fiber positioning, 80 simulations using humidifiers with different fiber numbers and placements are carried out and analyzed for two operating points. Two statistical metrics, the wrap-around discrepancy and a distance-based metric called MaxiMin, are used to assess the uniformity and space-filling properties of the fiber placements. Correlations of the uniformity of fiber placement and the water transfer inside hollow fiber bundles are then identified. Furthermore, it is demonstrated that both, the wrap-around discrepancy and the MaxiMin, can be used as optimization criterion for the fiber placement inside humidifiers to maximize water transfer rates. The optimization leads to an average improvement of 5 % in water transfer compared to a median random fiber distribution.
Resting metabolic rate and energy efficiency in response to an intensive 84-day combat-swimmer training in the German Armed Forces
Authors: Richter Tony H. , Braun Wiebke , Scheit Lorenz , Schröder Jan , Reer Rüdiger , Harth Volker , Bender Katrin , Koch Andreas , Bosy-Westphal Anja , Müller Manfred J. 
Published: November 2024

Abstract
Purpose
According to the ‘constrained model’, there are compensations in resting metabolic rate (RMR) at high levels of physical activity (PA). Here, we have used a standardized combat-swimmer training protocol (CST) to investigate whether changes in RMR (i) confirm the ‘constraint model’, and (ii) differ between successful participants and dropouts.

Methods
Controlled 84d CST in 44 male soldiers with 13 finally successful. Fat mass (FM) and fat-free mass (FFM) were measured using Quantitative Magnetic Resonance. RMR was assessed by indirect calorimetry, VO2max, and work efficiency by treadmill spiroergometry. Plasma levels of thyroid hormones, testosterone, and cortisol were analysed by standard laboratory methods.

Results
CST increased VO2max (+ 6.9%) and exercise efficiency at low workloads of 10 and 12 km/h (+ 8.7 and + 6.5%; both p < 0.05). As energy balance was moderately negative (−356 ± 383 kcal/d), FFM and FM decreased (−2 and −16%; both p < 0.05). There was a considerable inter-individual variance but no change in in the mean values of RMR and RMRadjFFM. RMRadjFFM before CST had a negative association with its decrease with CST (p < 0.005). Concomitantly, plasma hormone levels were unchanged. When compared with dropouts, successful participants had a higher VO2max at baseline (5.2 ± 0.6 vs. 4.9 ± 04 l/min; p < 0.05) that increased with CST (+ 4.4 vs. −0.4%; p < 0.05) at similar changes in body composition and energy balance.

Conclusion
While CST increased VO2max and exercise efficiency as a compensation, there was an inter-individual variance in exercise-related compensation of RMR with no differences between ‘completers’ and ‘non-completers’.
Trial registration DRKS00018850, November 27, 2019.
Erfassung und Visualisierung unterirdischer Bewegungsräume zur Vervollständigung des Lagebilds in Urban Operations
Authors: Kern Josef , Rauch Carl , Wenighofer Robert , Schneider Daniel , Weitzer Mario 
Published: November 2024

ZusammenfassungIm Forschungsprojekt EVUB (Erfassung und Visualisierung von unterirdischen Bewegungsräumen zur Vervollständigung des Lagebilds in Urban Operations) wurden die relevanten Geo-Faktoren, Infrastruktur und Bewegungsräume definiert, die als Grundlage für eine 3D-Darstellung für das Österreichische Bundesheer verwendet werden können.Als Untersuchungsgebiet für einen Prototyp wurde ein Gebiet rund um den Wiener Karlsplatz definiert, um festzustellen, welche Daten aus öffentlichen Quellen recherchiert werden können und in welcher Qualität und Quantität diese vorliegen. Ferner wurde erhoben, welche nicht öffentlich zugänglichen Daten (Closed-Data) bereitgestellt und unter welchen Umständen diese Daten im Projekt verwendet werden können.Im Testgebiet wurden verschiedene Erhebungsmethoden und -technologien erprobt: von der Modellierung von CAD-Gebäudeplänen über die Erfassung von Strukturen mit LiDAR-Scanner und einer Mixed Reality-Brille, zum Vermessen von Baustrukturen mit einem Laser-Entfernungsmessgerät und deren Verbindung mit Echtdaten für unzugängliche Areale.Erhobene Daten wurden als 3D-Modelle aufbereitet und erfolgreich in das Führungsinformationssystem des NIKE-Forschungs- und Entwicklungsprogramms der Theresianischen Militärakademie integriert, wo diese Informationen von Einsatzkräften mit Hilfe von Augmented Reality genutzt werden können.Ein wesentliches Projektziel war es, die Dimensionen und Komplexitäten der Thematik zu verstehen und auf dieser Grundlage den Aufwand einer Ausrollung in einem größeren Stadtgebiet sowie für aufwändigere Visualisierungen abschätzen zu können.Für eine Ausweitung des Projekts auf die Erstellung eines österreichweiten Untertage-Atlasses wurden Vorarbeiten geleistet, die – bei entsprechender finanzieller und inhaltlicher Unterstützung der Städte und Gemeinden – in der nächsten Phase umgesetzt werden können.
Strukturparameter des Rettungswesens in Deutschland – Ergebnisse einer bundesweiten Abfrage und politische Einordnung
Authors: Wolff Justus , Breuer Florian , Pommerenke Christopher , Dahmen Janosch 
Published: November 2024

ZusammenfassungVor dem Hintergrund einer immer stärker wachsenden Inanspruchnahme der Notfallversorgung respektive des Rettungsdiensts ist der Ruf aus dem Gesundheitswesen und der Wissenschaft nach einer umfassenden Notfallreform in Deutschland immer lauter geworden. Die vorliegende Publikation analysiert erstmals für über 50 der bevölkerungsreichsten Gebietskörperschaften, zusammengesetzt aus Großstädten und Landkreisen in Deutschland, deren Strukturparameter des Rettungswesens. Dies soll als ein Grundstein für eine sachliche Diskussion über die Zukunft und Ausgestaltung einer Reform des deutschen Rettungsdiensts dienen. Im Mittelpunkt stehen die Auswertungen von Inanspruchnahme, Leistungs- und Strukturparametern, basierend auf einer Umfrage unter den Ärztlichen Leitungen Rettungsdienst (ÄLRD) aus 50 unterschiedlichen Gebietskörperschaften. Die Ergebnisse lassen schlussfolgern, dass die Art der Notrufabfrage Einfluss auf den Umfang der Einsatzmittelvorhaltung hat. Weiterhin zeigt die Analyse der zum Thema publizierten Literatur und inzwischen vorliegenden wissenschaftlichen Stellungnahmen beziehungsweise Gutachten, dass eine bundeseinheitliche, koordinierte und umfassende Reform der Notfallversorgung einschließlich der Teilbereiche Leitstelle, Rettungsdienst und integrierte Notfallzentren dringend erforderlich ist. Mithilfe der in dieser Arbeit vorgestellten Umfrageergebnisse werden Bausteine für eine evidenzbasierte Grundlage der Diskussion um den Rettungsdienst in Deutschland gelegt und wichtige Einblicke für zukünftige Entscheidungen auf allen exekutiven und legislativen Ebenen gegeben.
EchiNam: multicenter retrospective study on the experience, challenges, and pitfalls in the diagnosis and treatment of alveolar echinococcosis in Belgium
Authors: Plum Pierre-Emmanuel , Ausselet Nathalie , Kidd François , Noirhomme Séverine , Garrino Maria-Grazia , Dili Alexandra , Hayette Marie-Pierre , Detry Olivier , Leonard Philippe , Motet Christian , Hites Maya , Bourgeois Marc , Montesinos Isabel , Delaere Bénédicte 
Published: November 2024

Abstract

Objectives
The aim of this retrospective study was to collect epidemiological, clinical, laboratory, imaging, management, and follow-up data on cases of alveolar echinococcosis (AE) diagnosed and/or followed up within the Namur Hospital Network (NHN) in order to gather information on the challenges, pitfalls, and overall experience in the diagnosis and treatment of AE.

Methods
EchiNam was a multicenter retrospective study. Patients diagnosed and/or treated for probable or confirmed AE in the NHN between 2002 and 2023 were included in the study. Patient selection was based on diagnosis codes, laboratory results, and albendazole (ABZ) dispensing.

Results
A total of 22 AE cases were retrieved, of which four were classified as probable and 18 as confirmed cases. Nine patients were either asymptomatic or had symptoms attributed to another disease. Clinical examination yielded pathologic findings in 10 patients. The median duration from the first AE-suggestive laboratory abnormalities to diagnosis was 176 days, and the median duration from the first AE-related imaging abnormalities to diagnosis was 133 days. Overall, 12 patients underwent surgical resection, with only four achieving complete lesion resection. Nine patients experienced ABZ-related adverse effects, with temporary ABZ discontinuation in five.

Conclusion
Due to various factors such as a long incubation period and a lack of awareness among Belgian physicians, AE is often diagnosed at advanced disease stages. Treatment then becomes more complex or even suboptimal, resulting in prolonged therapy, higher risk of adverse effects, significantly impaired quality of life, poor prognosis, and higher mortality rates. Measures should be taken to achieve early diagnosis in endemic areas.
Ionospheric tomography for SWARM satellite orbit determination using single-frequency GNSS data
Authors: Prol Fabricio S. , Pignalberi Alessio , Smirnov Artem , Pezzopane Michael , Christovam Ana L. , Selvan Kannan , Hoque Mainul , Kaasalainen Sanna 
Published: November 2024

Abstract
Ionospheric tomography offers three-dimensional (3D) description of the electron density distribution, enabling the direct incorporation of electron density data into the slant total electron content (STEC) computation. As a result, STEC derived from tomography helps mitigate the ionospheric delay experienced in the line of sight between global navigation satellite systems (GNSS) and satellites positioned in low Earth orbits (LEO). Tomography can therefore be effectively employed to correct single-frequency GNSS observations and allow enhanced positioning of spaceborne platforms. We demonstrate the accuracy and performance of a global-scale ionospheric tomography method for determining satellite orbits, utilizing single-frequency GNSS measurements combined with a precise point positioning (PPP) algorithm. We compare the tomographic outcomes against orbit determination derived from the GRoup and PHase ionospheric correction (GRAPHIC) observable and based on an ionospheric climatological model. Near the peak of solar cycle 24, the overall accuracy achieved with tomography was around 3.8 m. notably, compared to the background climatological model, tomography demonstrated improvements ranging from 15 to 20%. The GRAPHIC method outperformed tomography, achieving an accuracy of 0.7 m, whereas we obtained around 7 m accuracy when no ionospheric model is employed. Although the developed ionospheric tomography has yet to match the precision of GRAPHIC, our results bring us relatively closer to this objective.
Characteristics of patients hospitalized for falls: electronic health records analysis
Authors: Schuster Anna Kathrin , Kesselmeier Miriam , Weisbach Laura , Stumme Christoph , Behringer Wilhelm , Hartmann Michael , Farker Katrin 
Published: November 2024

Abstract
Aim
Falls are common adverse events, often leading to hospitalization with adverse effects on the physiological and psychological health of patients. Although risk factors for falls are well examined, it is difficult to identify fallers through their electronical health records (EHR). This study investigates whether EHR contain characteristics that indicate a fall before hospitalization.

Subject and methods
We evaluated 500 EHR of patients hospitalized through the Department of Emergency Medicine of Jena University Hospital. We considered electronically available characteristics including free texts and ICD-10-GM codes. Inpatients with and without a fall event previous to their hospitalization were compared for significant differences in EHR characteristics. Therefore, we applied the Mann–Whitney U test and the exact Fisher test, respectively, with a two-sided significance level of 0.05 and without correction for multiple testing.

Results
It was possible to identify significant differences between fallers and non-fallers by gender (66.3% women), age (median: 84 years), living situation prior to hospital admission (20.5% from nursing home, 41.1% living alone) and type of discharge. Besides other risk factors, ICD-10-GM codes included injuries, especially fractures and superficial injuries, but also cognitive deficits, incontinence, and physical limitations were more prevalent with fallers than non-fallers.

Conclusion
This study identified characteristics that can support identification of fall patients through EHR. Such information should be tested in other hospitals and is expected to enhance patient safety and utilization of healthcare resources.