bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transversal Maxillary Distraction in Patients with Cleft Lip and Palate
Authors: Martinez Plaza Adoración , Bullejos Martínez Elena , Cariati Paolo , Fernández-Valdés Gámez Ricardo , España López Antonio , Fernández Valadés Ricardo 
Published: February 2019

Objective:
The aim of this study is to describe the importance of osteodistraction with transpalatal distractors for treating transversal maxillary hypoplasia in patients with cleft and lip palate.

Methods:
The participants were 17 patients (9 females and 8 males) with cleft lip and palate. Among these, 10 presented unilateral cleft lip and palate, 4 bilateral cleft lip and palate, and 3 cleft palate only.

Results:
All patients experienced a satisfactory palatal expansion and crossbite correction. The mean lengthening was 12.7 mm. The average increase of intercanine distance, intermolar distance, maxillary transverse dimension (MTD), facial transverse dimension (FTD) was 12.16, 8.45, 1.77, and 1.67 mm, respectively. The clinical follow-up was 29.7 months (range: 6–61 months).

Conclusion:
Palatal distraction is a safe and successful alternative for treating maxillary transversal alterations in patients with cleft lip and palate. This technique facilitates the establishment of an adequate transverse dimension of maxillary, and consequently a proper dental occlusion.
Langerhans Cell Histiocytosis in the Pediatric Population: Treatment of Isolated Craniofacial Lesions
Authors: Gargano Francesco , Welch Jennifer J. , Klinge Petra M. , Sullivan Stephen R. , Taylor Helena O. 
Published: February 2019

Abstract
Langerhans cell histiocytosis (LCH) commonly affects the craniofacial skeleton and prognosis depends on location, extension, and recurrence of the disease. The aim of our study is to better define the treatment of single craniofacial lesions, as to date different treatment modalities have been suggested and recurrence rates for both unifocal and multifocal bony lesion range between 10% and 70%. Between 2000 and 2014, we retrospectively reviewed clinical findings, anatomic location, extent of the disease, therapy, and outcomes in 24 pediatric patients with histologically confirmed LCH. Seventeen patients (67%) had craniofacial involvement, of which 13 had single system involvement and 4 had multisystem involvement. Eight patients (33%) had no craniofacial involvement. Eleven patients affected by unifocal cranial lesions were treated with resection and reconstruction. One patient with a unifocal mastoid lesion was treated with chemotherapy alone (vinblastine and prednisone). Four patients with mandible lesions were treated with curettage alone.
There were no recurrences in patients treated with excision alone. One patient (25%) treated with curettage recurred. Two patients with diffuse disease manifested organ dysfunction and diabetes insipidus. Chemotherapy was tolerated in 12 patients treated.
Our findings suggest that resection of isolated LCH lesions of the cranium is safe and chemotherapy is effective and well tolerated for nonsurgical cases.
Prevalence of Bifid Zygomaticus Major Muscle
Authors: Phan Kevin , Onggo James 
Published: February 2019

Abstract
Facial expression muscles have significant morphological variability, including its size, shape, attachment patterns, and prevalence. The zygomaticus major (ZMj) represents one such important structure involved in facial expressions. The bifid ZMj muscle is a known anatomical variation that clinically presents as a dimple in the cheek; however, its prevalence and variation with ethnicity and geography remains poorly understood. The authors performed the first meta-analysis examine and established the prevalence of bifid ZMj variant across different population groups. From 7 studies identified via electronic databases, the prevalence of bifid ZMj variant was most prominent in the American subgroup 34% (95% CI 22.3%–48%), followed by the Asian subgroup at 27.4% (95% CI 14.3%–46.1%) and European subgroup at 12.3% (95% CI 6.5%–22.1%). Subgroup difference was found to be statistically significant (P = 0.027). The overall prevalence of the bifid ZMj is 22.7% (95% CI 14.3%–34.2%). This contributes to the understanding of various facial muscle morphologies and attachment patterns, which have significant implications in surgical planning and procedures for facial reanimation and recreation of natural patient appearances.
What Is a Safe Distance for Preservation of the Inferior Alveolar Nerve in Lower Gingival Squamous Cell Carcinoma? A Radiographic and Histopathological Study
Authors: Tabrizi Reza , Farahani Zeinab , Barouj Mehrdad Dehghanpour , Kheirkhahi Mahtab , Jafari Mehrshad , Sadeghi Hassan Mirmohammad 
Published: February 2019

Purpose:
Involvement of the inferior alveolar nerve (IAN) is important in the prognosis and treatment of gingival squamous cell carcinoma (SCC).

Methods:
In this cross sectional study, patients with gingival SCC (T4a), undergoing hemimandibulectomy or subtotal hemimandibulectomy, were examined. The distance between the lesion and inferior alveolar canal (IAC) was measured, using axial computed tomography scans before resection. Following that, histopathological evaluation of IAN was conducted. The receiver operating characteristic curve was plotted to determine the association of IAN involvement in histopathological evaluation with various distances between the lesion and IAC.

Results:
A total of 29 patients were examined in this study. The mean distance between the lesion and IAC was 9.40 ± 2.21 mm. Nerve involvement was documented in 9 (45%) out of 20 males, while 11 (55%) men showed no involvement. Thirteen (44.82%) patients showed IAN involvement. The receiver operating characteristic curve demonstrated a cut-off point of 9.75 mm for the lesion-IAN distance. The possibility of IAN involvement was 23.33 times higher in patients who reported paresthesia, compared with patients without nerve involvement (odds ratio, 23.33; 95% CL; P = 0.001)

Conclusion:
It seems that in a CT scan view, a 9.75-mm safe margin is associated with high accuracy for preserving IAN in patients with gingival SCC. Also, neurosensory disturbance can be considered a strong predictor of IAN involvement.
Tracheoesophageal Puncture Site Closure With Butterfly Cartilage Graft
Authors: Yenigun Alper , Ozturan Orhan , Kulaksiz Yasin , Aksoy Fadlullah , Tugrul Selahattin 
Published: February 2019

Abstract
A tracheoesophageal voice prosthesis is very effective for improving speech after total laryngectomy. Although it is generally a safe method, it may be necessary to close the tracheoesophageal fistula due to complications such as prosthesis-related cellulitis, granulation tissue formation, tracheoesophageal fistula necrosis, or salivary leakage around the prosthesis. Surgical and non-surgical methods for closure have been described. In this article, a method for closing the tracheoesophageal fistula with a butterfly cartilage graft is described. The butterfly cartilage technique is safe and efficient in terms of anatomical closure of the fistula. This study shows that the method can be easily applied, with low morbidity, using an auto-graft material with local anesthesia in an outpatient setting.
Clinical Application of Temporary External Fixator for Immediate Mandibular Reconstruction
Authors: Yin Xue-lai , Tan Yi-ran , Liu Ying , Sun Wen-wen , Zhang Xin-yu , Hu Yong-jie , Sun Jian , Zhang Chen-ping , Zhong Lai-ping 
Published: February 2019

Abstract
Immediate mandibular reconstruction is always necessary for the patients receiving segmental mandibulectomy to recover the facial contour and function of occlusion. When 3D modeling is unavailable, temporary external fixator is necessary to maintain the occlusion relationship and facial contour. In this study, we introduce the clinical application of temporary external fixator for immediate mandibular reconstruction in patients receiving segmental mandibulectomy, which consists of 2 anchor claws, 2 all-round retentive arms, and 1 central locking structure. From August 2016 to September 2017, temporary external fixator was applied in 13 patients. Clinical data of gender, age, surgical procedure, duration of operation, and clinical outcomes were recorded and analyzed. Among the 13 patients, there were 4 men and nine women whose ages ranged from 21 to 64 (mean 47.7) years old. There were 9 benign and 4 malignant lesions. All lesions expended at the buccal side of mandible. 12 fibular flaps and 1 vascularized iliac bone graft were used. The mandibular defect ranged from 6 to 14 (mean 10) cm. The operation duration of surgery ranged from 5 to 10 (mean 7) hours. All flaps survived with primary healing. The occlusion and facial contour were good, without significant changes of the length of mandibular body and width of mandible before and after surgery. No functional sequelae were noted at the donor sites. From these results, the temporary external fixator is easy to operate; the surgical procedure is simple and time-saving for surgeon when 3D modeling is unavailable. The indication for temporary external fixator usage is the mandibular lesion growing outward to cheek soft tissue.
Likelihood of Diagnosing Neuroblastoma in Isolated Horner Syndrome
Authors: Ben Shabat Avi , Ash Shifra , Luckman Judith , Toledano Helen , Goldenberg-Cohen Nitza 
Published: February 2019

Background:
The need for an extensive evaluation for neuroblastoma in children with Horner syndrome is controversial.

Methods:
A retrospective study design was used. The cohort included 47 children with anisocoria who were diagnosed with Horner syndrome and 135 children with neuroblastoma evaluated at a pediatric medical center between 2007 and 2015. To detect neuroblastoma, patients with Horner syndrome underwent brain and cervical MRI, abdominal ultrasound, and/or measurement of urinary vanillylmandelic acid (VMA). The neuroblastoma group was evaluated for signs/symptoms of Horner syndrome at the time of diagnosis.

Results:
Seven patients with Horner syndrome were lost to follow-up, and the findings of the remaining 40 were categorized according to the age of the patient. Horner syndrome most frequently was idiopathic (58%), and in only 1 patient did the discovery of neuroblastoma precede the appearance of Horner syndrome. In the 21 patients aged 1–18 years, Horner syndrome was acquired in 15 patients and congenital in 6. The most common etiology was trauma (62%). Imaging was performed in 14 patients and VMA testing in 13. Neuroblastoma was diagnosed in 5 patients; in none was it related to Horner syndrome. In the 135 patients with neuroblastoma, most of the tumors were diagnosed at Stage 4 (60%) or Stage 3 (30%) with 53% originating in the abdomen. In one patient (0.74%) with signs/symptoms of Horner syndrome at diagnosis of neuroblastoma, the tumor had been identified prenatally and the diagnosis confirmed by imaging postnatally.

Conclusions:
The absence of occult neuroblastoma in children with Horner syndrome and of signs/symptoms of Horner syndrome in the children diagnosed with neuroblastoma suggests that Horner syndrome might not be as frequent a cause of neuroblastoma as previously thought. We recommend that full investigation for neuroblastoma be reserved for suspicious cases associated with additional systemic signs or symptoms.
Can one trust kinetic and thermodynamic observables from biased metadynamics simulations: detailed quantitative benchmarks on millimolar drug fragment dissociation
Authors: Pramanik Debabrata , Smith Zachary , Kells Adam , Tiwary Pratyush 
Published: February 2019

AbstractObtaining atomistic resolution of ligand dissociation from a protein is a much sought after experimental and computational challenge. Structural details of the dissociation process are in general hard to capture in experiments, while the relevant timescales are far beyond molecular dynamics (MD) simulations even with the most powerful super-computers. As such many different specialized enhanced sampling methods have been proposed that make it possible to efficiently calculate the dissociation mechanisms in protein-ligand systems. However, accurate benchmarks against long unbiased MD simulations are either not reported yet or simply not feasible due to the extremely long timescales. In this manuscript, we consider one such recent method “infrequent metadynamics”, and benchmark in detail the various thermodynamics and kinetic information obtained from this method against extensive unbiased MD simulations for the dissociation dynamics of two different millimolar fragments from the protein FKBP in explicit water with residence times in nanoseconds to microseconds regime. We find that the metadynamics approach gives the same binding free energy profile, dissociation pathway and ligand residence time as the unbiased MD, albeit using only 6 to 50 times lower computational resources. Furthermore, we demonstrate how the metadynamics approach can self-consistently be used to ascertain whether the reweighted kinetic constants are reliable or not. We thus conclude that the answer to the question posed in the title of this manuscript is: statistically speaking, yes.
A Novel Integrative Multiomics Method Reveals a Hypoxia-Related Subgroup of Breast Cancer with Significantly Decreased Survival
Authors: Pouryahya Maryam , Oh Jung Hun , Javanmard Pedram , Mathews James C. , Belkhatir Zehor , Deasy Joseph O. , Tannenbaum Allen R. 
Published: February 2019

AbstractThe remarkable growth of multi-platform genomic profiles has led to the multiomics data integration challenge. The effective integration of such data provides a comprehensive view of the molecular complexity of cancer tumors and can significantly improve clinical out-come predictions. In this study, we present a novel network-based integration method of multiomics data as well as a clustering technique involving the Wasserstein (Earth Mover’s) distance from the theory of optimal mass transport. We applied our proposed method of integrative Wasserstein-based clustering (iWCluster) to invasive breast carcinoma from The Cancer Genome Atlas (TCGA) project. The subtypes were characterized by the concordant effect of mRNA expression, DNA copy number alteration, and DNA methylation as well as the interaction network connectivity of the gene products. iW-Cluster is substantially more effective in distinguishing clusters with different survival rates as compared to isolated one-dimensional conventional omics analysis. Applying iWCluster to breast cancer TCGA data successfully recovered the known PAM50 molecular subtypes. In addition, iWCluster preserves the gene-specific data, which enables us to interpret the results and perform further analysis of significant genes for a specific cluster. The gene ontology enrichment analysis of significant genes in our substantially low survival sub-group leads to the well-known phenomenon of tumor hypoxia and the transcription factor ETS1 whose expression is induced by hypoxia. Increased expression of ETS1 is associated with an increased risk of recurrence and worse prognosis in breast cancer. Consequently, we believe iWCluster has the potential to discover novel subtypes by accentuating the genes that have concordant multiomics measurements in their interaction network, which are challenging to find without the network inference or with single omics analysis.
Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936
Authors: Hillary Robert F. , McCartney Daniel L. , Harris Sarah E. , Stevenson Anna J. , Seeboth Anne , Zhang Qian , Liewald David C. , Evans Kathryn L. , Ritchie Craig W. , Tucker-Drob Elliot M. , Wray Naomi R. , McRae Allan F. , Visscher Peter M. , Deary Ian J. , Marioni Riccardo E. 
Published: February 2019

AbstractAlthough plasma proteins may serve as important markers of disease risk in neurological conditions, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. In this study, we conducted genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750). We identified 62 independent genome-wide significant loci for 37 proteins (P < 5.4 × 10−10) and 68 epigenome-wide significant sites associated with the levels of 7 proteins (P < 3.9 × 10−10). Using this information, we identified biological pathways in which putative neurological biomarkers are implicated as well as molecular mechanisms through which genetic variation may perturb plasma protein levels. Additionally, we found evidence that poliovirus receptor is causally associated with Alzheimer’s disease. In conclusion, we identified many novel genetic and epigenetic factors that are associated with neurological protein levels which may inform disease biology and establish causal relationships between biomarkers and neurological diseases.
Antagonistic framing of sustainability by energy suppliers
Authors: Weder Franzisca , Koinig Isabell , Voci Denise 
Published: February 2019

PurposeThe purpose of this paper is to determine inasmuch energy suppliers dedicate communicative resources toward sustainable development and corporate social responsibility (CSR), also paying attention to how they frame it, and if they manage to achieve consistency in their communication or fall victim to contradictions.Design/methodology/approachBy use of a qualitative content analysis, online communication tools (information on corporate websites) as well as content for download were examined in detail. The present study sample comprised of 12 case studies from selected countries (Austria, Russia, Germany, the USA, France and Korea).FindingsOverall, findings indicate that CSR has already been implemented in most energy and energy-related industries; however, it is put forward with varying degrees of attention and intensity, depending on which topics energy companies choose to address communicatively (results were classified according to a frame positioning scheme by Weder, 2012, 2018). Results underscore the fact that, at times, companies are struggling to link their CSR projects back to their core businesses. Yet, a clear trend to politicization can be described as a strong correlation of communication strategies of energy suppliers and political programs of the respective country becomes obvious.Research limitations/implicationsLimited research as to how CSR topics are framed in different branches has been conducted to date; likewise, the energy sector, whose motives has been often subject to public questioning, has received little attention in CSR communication research to date. Hence, ambiguities were presumed to exist.Originality/valueThe present study examines the relevance and framing of CSR in a highly competitive, centralized industry that is challenged by a global process of transition to renewable energy. The results show that the analyzed energy suppliers offer only a limited variety of issue-specific frames; instead CSR as well as sustainability are (ab)used as master frames or “buzz words” in a fairly shallow economic or socio-political argumentation.
Resource budget for workface planning in industrial-construction
Authors: Siu Ming Fung Francis 
Published: February 2019

Purpose
The purpose of this paper is to develop a novel analytical approach for workface planning practice in industrial-construction sector such that the construction work package (CWP) resource budget can be sufficiently planned for delivering possible field installation work package (FIWP) schedules with work uncertainty.

Design/methodology/approach
The relationship between CWP resource budget and FIWP schedules is first elucidated based on workface planning practice. The literature of work packaging, workface planning and project scheduling is reviewed. A novel analytical approach is then developed to quantify CWP resource budget based on a probability theory, in consideration of the probability of occurrence of feasible FIWP schedules formulated based on a resource scheduling approach. The results of case studies given by the new approach are cross validated by using simulation and optimization techniques.

Findings
The new analytical approach can assist workface planning by quantifying the expected CWP resource budget to deliver the FIWP work scope with certain activities that are planned at project level and with uncertain activities that are found at workface level.

Practical implications
The new analytical approach helps project and workface planners to reliably deploy CWP resource budget for delivering FIWP schedules instead of guessing the budget based on experience. An industrial-construction project for upgrading oil-sands refinery facility is used to show the practical implications.

Originality/value
This research develops a new analytical approach for workface planning practice to determine sufficient CWP resource budget for delivering feasible FIWP schedules with work uncertainty.
Perceived corporate social responsibility performance in professional football and its impact on fan-based patronage intentions
Authors: Liu Dongfeng , Wilson Rob , Plumley Daniel , Chen Xiaofeng 
Published: February 2019

Purpose
The purpose of this paper is to analyze fans’ perceptions of the corporate social responsibility (CSR) activities of a professional football club, specifically whether or not perceived CSR performances are then likely to influence patronage intentions of the fans in relation to the football club.

Design/methodology/approach
The paper uses the example of a professional football club in China as a case study for data analysis. Based on a sample of 451 home team fans, analysis was conducted through calculation of descriptive statistics, and exploratory factor analysis. Regression analysis was conducted to determine the impact of perceived CSR performance on fans’ patronage intentions.

Findings
The results revealed that factor 3 (“CSR to customer and employee”) and factor 4 (“Community development and youth education”) were significantly predictive of all the three patronage intention variables, i.e. repeat purchase, word-of-mouth and merchandise consumption. In addition, factor 2 (“charity”) would also affect merchandise consumption intention, but have no effect on any other dimensions.

Originality/value
A scale measuring perceived CSR performance in professional football clubs by the fans in the Chinese context has been developed. In addition, the authors have identified that the two main CSR factors that would influence fans’ patronage intentions are: “CSR to the customer and employee” and “community development and youth education.” Thus, if football clubs are to use CSR strategically to leverage spend, then it is these two areas that they should focus on, explicitly in relation to CSR activities. This paper adds value to an area that is currently under-researched in respect of CSR activities in Chinese professional football.