bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination Therapies of Hypomethylating Agents for Elderly Patients with Acute Myeloid Leukemia
Authors: Huang Jiayu , Lian Yun , Qian Sixuan 
Published: September 2018

AbstractOlder patients with acute myeloid leukemia (AML) are encumbered with poor long-term outcomes due to patient and disease characteristics. Hypomethylating agents (HMAs), acting as DNA methyltransferase (DNMT) inhibitors, have been established as a new treatment option, but they have been associated with relatively low response rates (15%–20% complete remission) when administered separately for treating elderly with AML. However, appropriate combination therapies with decitabine or azacitidine have flourished. The results of randomized trials of various combinations of HMAs with chemotherapy, histone deacetylase inhibitors, monoclonal antibodies, immunomodulatory agents, kinase inhibitors, or bexarotene are summarized.
Bankowanie. Mikrobiologiczne bezpieczeństwo przeszczepienia krwiotwórczych komórek macierzystych
Authors: Ewa Bembnista , Agnieszka Kubiak , Paula Matuszak , Maria Kozłowska-Skrzypczak 
Published: September 2018

StreszczenieW procesie przygotowania komórek krwiotwórczych (k.k.) do transplantacji istotne jest wdrożenie oraz utrzymanie procedur pozwalających na zachowanie mikrobiologicznego bezpieczeństwa przeszczepu. Do głównych źródeł zanieczyszczenia przeszczepu należy: powietrze, personel, woda oraz materiał. Kontaminacja przeszczepu może mieć miejsce na etapie pozyskania, przetwarzania oraz dystrybucji k.k. Jakość materiału transplantacyjnego powinna być kontrolowana na wszystkich kluczowych etapach jego przetwarzania. Bankowanie k.k. może odbywać się w systemie otwartym lub zamkniętym. System przetwarzania k.k., otwarty lub zamknięty, znacząco wpływa m. in. na kryteria kwalifikacji pomieszczeń oraz przygotowania pracowników do pracy. Jednakże niezależnie od systemu przetwarzania k.k., kontrola mikrobiologiczna powinna obejmować zarówno materiał transplantacyjny, jak i środowisko jego przewarzania. Formalne wymogi dla banków komórek zawarte są w Rozporządzeniach Unii Europejskiej, Ustawie Transplantacyjnej oraz Rozporządzeniach Ministra Zdrowia. Wdrożenie oraz utrzymanie procedur odpowiedniego przygotowania pracowników, sprzętów oraz pomieszczeń do pracy w znaczący sposób wpływają na zmniejszenie ryzyka kontaminacji przeszczepu, a tym samym na kliniczne parametry leczenia transplantacyjnego.
Clinical and laboratory features of Adult T-cell Leukemia/lymphoma (ATL): a study of 37 cases
Authors: de Araújo Cristiane da Silva Rodrigues , Carmo Mirna Maira Bezerra Calazan do , Maximo Claudia de Alvarenga , de Carvalho Sílvia Maia Farias 
Published: September 2018

AbstractAdult T-cell leukemia/lymphoma (ATL) related to the human T-cell lymphotropic virus type I (HTLV-I) is a malignant lymphoproliferative disease. ATL is classified in four subtypes: lymphoma, acute, smoldering and chronic. We analyzed, retrospectively, 46 consecutive patients with T-cell disease with ATL diagnosed from 1995 to 2007. ATL diagnose was confirmed in 37 of these patients. There were 26 females and 11 males (70% vs 30%, respectively, p=0.014). The median age was 42 years old. Twenty-five were nonwhite and twelve were white (67.6% vs 32.4%, respectively, p=0.033).Twenty two patients had the acute form, eight had chronic form and seven had lymphomatous form. Two of them had osteolytic lesions. There were two cases with pulmonary infiltrates; one patient had ATL associated to Hansen’s disease. All cases had antibodies to HTLV-I confirmed by Western Blot, polymerase chain reaction (PCR) was performed in 22 cases. Flow cytometry revealed positivity for CD4 and CD25 in most cases. The mean and median overall survival time was 11.3 months and 2 months, respectively. The family´s study showed that 60% of the mothers were HTLV-I seropositive. These data emphasize the importance of a serologic screening for HTLV and immunophenotyping to differentiate ATL from others T-lymphoproliferative disorders.
Clinical and Radiological Assessment in Axial Spondyloarthritis
Authors: Ng Alexandra Yan Hoi , Ng Kam Hung 
Published: September 2018

Abstract
The Assessment of SpondyloArthritis International Society (ASAS) has developed the concept of axial spondyloarthritis (SpA) in 2009. The symptoms and burden of disease of nonradiographic axial SpA and Ankylosing Spondylitis (AS) are similar and both can affect multiple organs and systems. Assessment and monitoring in SpA are, therefore, crucial. Different instruments have been developed for assessing and monitoring the wide variety of presentations in SpA. Generally, disease monitoring of patients can include patient reported outcome, clinical findings, laboratory tests, imaging, and disease activity composite scores.
Chronic Traumatic Encephalopathy: The Horse Is Still Chasing the Cart
Authors: Asken Breton M. , Bauer Russell M. 
Published: September 2018

Chronic traumatic encephalopathy (CTE) occupies a unique and expanding position in both the scientific and lay communities concerned with sport participation at all levels. The benefits of rapid, widespread reporting and increased public awareness are counterbalanced by misinformation and an oversimplification of an increasingly complex topic. In this Viewpoint, we will describe the current understanding of CTE pathology and proposed criteria for characterizing traumatic encephalopathy syndrome (TES), the proposed clinical syndrome associated with underlying CTE pathology, but possibly other proteinopathies as well. We want to emphasize that CTE and TES are not the same entity, at least according to our current understanding. We additionally highlight those at greatest risk for CTE and the significant challenges to symptom attribution specific to these populations. J Orthop Sports Phys Ther 2018;48(9):672–675. doi:10.2519/jospt.2018.0612
Displaced Fracture Dislocation of the Proximal Humerus
Authors: Hunt Christopher , Markowski Alycia 
Published: September 2018

The patient was a 41-year-old man who injured his right shoulder falling onto his outstretched hand while skiing. Radiographs taken in the emergency department demonstrated a 3-part fracture dislocation of the proximal humerus for which he underwent same-day surgery. Physical therapy was initiated on postoperative day 27, and postoperative radiographs and physical examination results assisted in devising an appropriate plan of care and treatment. J Orthop Sports Phys Ther 2018;48(9):728. doi:10.2519/jospt.2018.6208
The Effect of Playing Video Advertisement Inside a Car on Driver Visual Distraction
Authors: Abhari Mohammadreza , Tabibi Masoud , Moghadas Nejad Fereydoon , Ramezani Khansari Ehsan , Amini Ehsan 
Published: September 2018

With the development of in-car technologies and the use of portable devices such as tablets inside the car, one of the most interesting topics for different companies might be to promote advertising within the car. The most important issue with regard to advertising inside the vehicle is the safety issues and issues related to driver distraction. The NHTSA regulation, restricted in- car advertising in 2014, whereas, by increasing the use of in-vehicle devices and technologies, in 2016 showing video images in the vehicles were allowed under certain circumstances. The current research aims to assess the degree of visual distraction of driver caused by video advertisements broadcasted inside a car. The results of this study indicate that the type of advertisement has a direct impact on the visual distraction of the driver. In addition, findings indicate that in case of playing an advertisement in a simple form (accommodated by a speech), a safer situation might be expected compared to situations in which the same advertisement has been broadcasted by a musical content (with or without a speech).
Behavior of Hybrid Reactive Powder Concrete Columns Exposed to Chloride Attack
Authors: Salman Mohammed \m. , Jarallah Husain K. , Al-Behadili Raed Satar 
Published: September 2018

In this paper, the cross section behavior of reinforced concrete columns made of normal and hybrid reactive powder concrete (hybrid by steel and polypropylene fibers) under concentric and eccentric vertical load was study. The casted columns were cured in two different type tap water for 28 days and chloride water for six months. Chloride salts with concentration was 8341.6 mg/l. Three variables were adopted in the experimental program; concrete type, curing type and the eccentricity of vertical load. Twenty (120x120x1200) mm columns were casted and tested depending on these variables. The different eccentricities were (0, 50,100 and 150) mm and where (e/h) were (0, 0.42, 0.83 and 1.25) respectively from the center of column, the other types of loading are tested the specimens as beam.
The experimental results showed increasing in ultimate load capacity and higher chlorides resisting for hybrid reactive powder concrete in comparison with normal concrete in both types of curing (tap and chloride water). Through studying load deflection, test results for Normal Strength Concrete (NSC) and Hybrid Fiber Reactive Powder Concrete (HFRPC) columns that deflection for columns cured in chloride water more than tap water when compared at the same load that also by increase eccentricity leads to an increase in deflection for both cured and The neutral axis depth for HFRPC columns is more than NSC at the same load also when eccentricity increases, the compression zone decreases and neutral axis also decrease by increase eccentricity. These results occur when columns are cured in tap and chloride water.
“Pengaruh Adversity Quotient Terhadap Kinerja Karyawan Melalui Motivasi Kerja Sebagai Variabel Intervening (“Studi Pada Pengemudi Taksi Konvensional di Kota Medan)”
Authors: Lubis Anggia Sari 
Published: September 2018

<p align="center"><strong><em>Abstract</em></strong></p><p> <em>The purpose of this study is to analyze and determine the effect of adversity quotient on Employee Pe-formance Through Job Motivation as an intervening variable in the conventional taxi driver in Medan. The nature of this study was associative,and the type of this research was quantitative. A sample of this research are 253 conventional taxi driver in Medan. The data that has been collected through a valid and reliable questionnaire,</em> <em>then processed using Path analysis approach. Results of this study are (1) adversity quotient has positive effect and significant effect on the employee performance, (2) adversity quotient has positive and significant effect on job motivation, (3) Job motivation has a positive and significant effect on the employee performance, (4) Job motivation was not as a perfect mediation between adversity quotient and employee performance. </em></p><p><em>.</em><em> </em></p><p><em> </em></p><p> </p>
PENGARUH PELAYANAN PURNA JUAL TERHADAP LOYALITAS PELANGGAN SIM CARD (SURVEI PADA MAHASISWA FAKULTAS EKONOMI UMN AL WASHLIYAH DAN UNIVA MEDAN)
Authors: Yuliana Yayuk 
Published: September 2018

Penelitian ini bertujuan untuk mengetahui pengaruh Pelayanan Purna Jual yang terdiri dari Garansi, Reparasi, dan Suku Cadang secara parsial dan simultan terhadap loyalitas pelanggan <em>sim card</em>. Jenis penelitian yang digunakan adalah penelitian (<em>explanatory research</em>) yang menggunakan pendekatan kuantitatif. Populasi sebanyak 488 orang mahasiswa. Sampel yang diambil sebanyak 100 responden dengan menggunakan teknik <em>purposive sampling</em>. Responden adalah pengguna produk <em>sim card</em> di dua universitas yaitu universitas Muslim Nusantara Al Washliyah dan Universitas Al Washliyah (UNIVA) Medan. Teknik analisis data menggunkan analisis deskriptif dan analisis regresi linier berganda dengan memperhatikan uji asumsi klasik dengan program <em>SPSS</em>. Hasil penelitian menunjukkan bahwa Pealyanan Purna Jual yang terdiri dari garansi, reparasi dan suku cadang secara parsial berpengaruh signifikan terhadap loyalitas pelanggan <em>sim card</em>, Layanan Purna Jual secara simultan berpengaruh signifikan terhadap loyalitas pelanggan <em>sim card</em>, Reparasi adalah variabel yang dominan memiliki pengaruh terhadap loyalitas pelanggan <em>sim card</em>. Hasil uji koefisien determinasi menunjukkan bahwa Garansi, Reparasi, dan Suku Cadang berpengaruh terhadap loyalitas pelanggan memiliki R<sup>2</sup> sebesar 90,7%.
Pembentukan Wilayah Pertahanan Dan Persoalan Agraria Di Pesisir Selatan Kebumen-Cilacap
Authors: Cahyati Devi Dhian 
Published: September 2018

AbstractThis paper describes the formation of defence area that often triggers agrarian questions at local level. The determination of defence area frequently aroused conflicts with local community having evidence of land ownership and cultivating the land for productive purposes. Ironically, military power, as an instrument for national defence claimed those land and use it for economic interests. This research uses qualitative method. Data collection was conducted by literature study, in-depth interviews and observation. This paper concludes that military defence was used as a tool to secure economic interests of the Colonial Government in colonial era. Furthermore, Indonesian military following this pattern in post-reform era. This means that there is a dislocation of authority when the Military uses public assets for their private interests. Intisari Tulisan ini menjelaskan mengenai pembentukan wilayah pertahanan yang sering kali memicu persoalan agraria di ranah lokal. Penentuan wilayah pertahanan sering kali memunculkan persoalan dengan masyarakat lokal yang memiliki bukti kepemilikan tanah dan menggunakan tanah tersebut untuk kegiatan produktif. Militer sebagai alat pertahanan negara secara ironis melakukan klaim tanah dan memanfaatkan tanah untuk kepentingan ekonomi mereka. Penelitian ini menggunakan metode kualitatif dengan metode pengumpulan data melaluistudi pustaka, wawancara mendalam dan observasi. Tulisan ini menyimpulkan bahwa pertahanan menjadi alat untuk mengamankan kepentingan ekonomi pemerintah kolonial dan diikuti oleh militer Indonesia pasca reformasi. Artinya terjadi dislokasi wewenang ketika militer menggunakan aset publik untuk kepentingan privat.
Pluralisme Hukum sebagai Strategi Pembangunan Hukum Progresif di Bidang Agraria di Indonesia
Authors: Puri Widhiana H 
Published: September 2018

Pluralism of agrarian law is a consequence of the choice of society law that has a diversity of culture, ethnicity, customs and religion. This condition creates the selection to use legal norms beside national laws defined by the state. The philosophy is to find and to acquire the most appropriate legal order and provide justice for the people. This concept consistent with the progressive nature of the law that led to a dynamic legal system and was processed following the dynamics of the community responsive to the needs and aspirations of justice in society. By using non state law as a complement of the state law, the chance of the state to quickly respons every dynamics of the community is possible, making the law progressive and responsive. This paper is a normative article with descriptive analytic from the perspective of philosophy of jurisprudence.Pluralisme hukum agraria adalah sebuah kondisi yang menjadi konsekuensi atas pilihan hukum masyarakat yang memiliki keragaman budaya, suku, adat istiadat serta agama. Kondisi ini menciptakan adanya pilihan norma hukum yang digunakan selain hukum nasional yang ditetapkan negara. Filosofinya adalah menemukan dan memperoleh tatanan hukum yang paling sesuai dan memberikan keadilan bagi masyarakat. Konsep ini sejalan dengan hakikat hukum progresif yang mengarah pada sebuah sistem hukum yang dinamis dan berproses mengikuti dinamika masyarakat sehingga responsif terhadap kebutuhan dan cita keadilan dalam masyarakat. Dengan menempatkan hukum masyarakat sebagai pelengkap hukum negara, maka peluang negara untuk merespon setiap dinamika dalam masyarakat secara cepat dapat dilakukan sehingga terwujud hukum progresif dan responsif. Kajian ini bersifat normatif dengan pendekatan deskriptif analitis dari perspektif filsafat ilmu hukum.
Adaptive low density parity check encoder for a complete free space optics/continuous variable-quantum key distribution system using commercially available off-the-shelf devices for variable throughput network considering dynamical atmospheric turbulence levels
Authors: Lopez Josue 
Published: September 2018

In this paper, an adaptive LDPC encoder for complete FSO/CV-QKD system using a COTS device for emulated dynamical atmospheric turbulence levels is presented. The experimental and emulation results show the maximum and minimal final secret key rates of 105 Kbps and 10 Kbps, respectively, for minimal and maximal throughput in a commercial network, 30 Mbps and 90 Mbps, respectively. Our proposal presents an adequate performance for weak and moderate atmospheric turbulence levels and a suitable option for improve the using of QKD systems.
Differential and integral cross sections for electron elastic scattering by ammonia for incident energies ranging from 10 eV to 20 keV
Authors: Aouchiche Hocine 
Published: September 2018

Differential and integral cross sections for elastic scattering of electron by NH3 molecule are investigated for the energy ranging from 10 eV to 20 keV. The calculations are carried out in the framework of partial wave formalism describing the target molecule by means of one center molecular Hartree-Fock functions. A spherical complex optical potential used includes a static part – obtained here numerically from quantum calculation – and fine effects like correlation, polarization and exchange potentials. The results obtained in this model point out clearly the role played by the exchange and the correlation-polarization contributions in particular at lower scattering angles and lower incident energies. Both differential and integral cross sections obtained are compared with a large set of experimental data available in the literature and well agreement is found throughout the scattering angles and whole energy range investigated here.
Single and staged laser interstitial thermal therapy ablation for cortical tubers causing refractory epilepsy in pediatric patients
Authors: Tovar-Spinoza Zulma , Ziechmann Robert , Zyck Stephanie 
Published: September 2018

OBJECTIVEMagnetic resonance–guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the authors report on clinical outcomes for a series of pediatric patients with tuberous sclerosis complex (TSC) and medication-refractory epileptogenic cortical tubers.METHODSA retrospective chart review was performed at SUNY Upstate Golisano Children’s Hospital in Syracuse, New York. The authors included all cases involving pediatric patients (< 18 years) who underwent MRgLITT for ablation of epileptogenic cortical tubers between February 2013 and November 2015.RESULTSSeven patients with cortical tubers were treated (4 female and 3 male). The patients’ average age was 6.6 years (range 2–17 years). Two patients had a single procedure, and 5 patients had staged procedures. The mean time between procedures in the staged cases was 6 months. All of the patients had a meaningful reduction in seizure frequency as reported by Engel and ILAE seizure outcome classifications, and most (71.4%) of the patients experienced a reduction in AED burden. Three of the 4 patients who presented with neuropsychiatric symptoms had some improvement in these domains after laser ablation. No perioperative complications were noted. The mean duration of follow-up was 19.3 months (range 4–49 months).CONCLUSIONSLaser ablation represents a minimally invasive alternative to resective epilepsy surgery and is an effective treatment for refractory epilepsy due to cortical tubers.
Altun Yaruk Sekizinci Kitap (Engin ÇETİN)'ın Yayın Tanıtımı
Authors: Karaman Ahmet 
Published: September 2018

Eski Uygur Türkçesi döneminin önemli eserlerinden biri olan Altun Yaruk üzerine Türkiye'de daha fazla çalışma yapılması gerekmektedir. Eski Uygur Türkçesiyle yazılmış eserleri Almanca'dan Türkiye Türkçesine çevirerek bilgi sahibi olmak biz Türkolog adayları açısından büyük bir açmazdır. İşte tam da bu noktada sayın Engin Çetin'in yapmış olduğu "Altun Yaruk Sekizinci Kitap" adlı çalışma oldukça önem kazanmaktadır. Biz de bu kitabın bir yayın tanıtımını yaparak bu alana katkı vermeyi düşündük.
ROMAN TEKNİĞİ BAKIMINDAN TAHSİN YÜCEL’İN “YALAN” ROMANI
Authors: KARABULUT MUSTAFA , Güvenç İpek 
Published: September 2018

Tahsin Yücel; öykü,
roman, deneme, eleştiri, çeviri vb. türlerindeki eserleriyle Cumhuriyet dönemi
Türk edebiyatında önemli, bir yere sahiptir. O,
entelektüel söylem gücünü anlatılarına başarıyla aktaran en önemli
romancılardandır. Göstergebilimin Türkiye’de tanınmasını sağlayan kişidir.
“Yalan” adlı romanı kuramsal yapıdan yararlanarak kurgulamıştır. Yazar bu
romanında günümüz toplum modelinin idolünü Yusuf Aksu’nun kişiliğinde gösterir.
Bu romanda “yalan, yapaylık yüzeysellik, gösteriş, düzenbazlık, riyakârlık,
pişmanlık” vb. konu ve temaları eleştirel bir üslupla anlatır. “Yalan” içinde
bulunulan toplumun intihal (aşırma) hastalığına, üniversite ortamında bile bu
hastalığın müptelası olan bilim insanlarına da bir eleştiri niteliğindedir. Çok
katmanlı bir roman olan “Yalan”, entelektüelin karşıt söylemi ekseninde,
bilimsel olarak geçerliliği olmayan bir kuramın; pasif, yönlendirilmeye yatkın
bir kişiye mal edilerek sonrasında gelişen olaylar üzerine kuruludur. Tahsin
Yücel’in alışılmışın dışında bir karakter seçerek onu topluma sunması, toplumun
onu koşulsuz şartsız kabullenmesi de içinde bulunduğumuz yalanın hangi
boyutlara ulaştığının göstergesidir. “Yalan” bu yönüyle her şeyden önce gerçekle
yalanın savaştığı günümüz toplumunda gerçeğin kazanmasını isteyen entelektüelin
çabasının romanıdır. Bu çalışmada amaç,
Tahsin Yücel’in “Yalan” adlı romanını roman tekniği bakımından tahlil etmektir.
Bu sebeple yazarın “Yalan” adlı romanı; konu, tematik düzlem, olay örgüsü,
kişiler, mekan, zaman, bakış açısı ve anlatıcı ve dil ve üslûp bakımlarından
incelendi.
AFGANİSTAN’DAN DERLENMİŞ TÜRKMENCE BİR MASAL
Authors: GÜLTEKİN Mevlüt 
Published: September 2018

Afganistan’da bir çok dil konuşulmaktadır.
Bu diller arasında Özbekçe, Türkmence, Azerice ve Kırgızca gibi Türk dilleri de
bulunmaktadır. Özbekçe, Azerice ve Kırgızca ile ilgili bazı çalışmalar yapılmış
olmakla beraber Afganistan’da konuşulan Türkmen ağızlarıyla ilgili hemen hemen
hiçbir şey yapılmamıştır. Bundan dolayı bu çalışmada Afganistan’da konuşulan
Türkmence bir ağız ele alınmaktadır. çalışmada Türkmen Türkçesinin Ersarı
ağzına giren, Kuzey Afganistan'ın Faryab İli
Qaramqol İlçesi Altıbölek beldesinde konuşulan Türkmen Türkçesi
ağzından kaydedilmiş bir masal metni çeviri
yazı alfabesiyle verilmektedir. Metin Türkiye Türkçesine aktarılmış, ses ve şekil bilgisi
özellikleri verilmiş ve çalışmanın sonuna, metinde
geçen bütün
kelimeleri, metindeki anlamlarıyla gösteren bir indeks konulmuştur. İndekste alıntı
kelimelerin kökenleri de verilmiştir.
Amacımız üzerinde çok az çalışma bulunan Afganistan Türkmen ağız
araştırmalarına küçük de olsa bir katkıda bulunmaktır.
Biogenic Synthesis of Silver and Gold Nano Particles using Fungal Species
Authors: Shaikh S M , Shaikh T J 
Published: September 2018

Gold and Silver nanoparticles synthesized by various technique have received special attention because they have found potential application in many fields such as catalysis, sensors, drug delivery system. Additionally, silver nanaparticles possess an excellent biocompatibility and low toxicity. The present investigation have done to check out the synthetic compatibility of Nano particles of some fungal strain i.e. Alternaria alternata, Aspergillus niger, Fusarium oxysporum, Pennicelium digitatum and Pennicelium spp.