bluuebunny/crossref_metadata_2025_split huggingface dataset:
VNS methods for home care routing and scheduling problem with temporal dependencies, and multiple structures and specialties
Authors: Frifita Sana , Masmoudi Malek 
Published: October 2018

AbstractThe need for optimization in the Home Care Service is becoming more and more legitimate in the face of the increase of demand and cost all over the world. Recently, many researchers in the Operation Research community have been attracted by this issue, which presents interesting aspects related to the vehicle routing problems. In this paper, we consider a new variant called the vehicle routing problem with time windows, temporal dependencies (synchronization, precedence, and disjunction), multi‐structures, and multispecialties problem (VRPTW‐TD‐2MS). This new variant is an extension of the vehicle routing problems with time windows and synchronization constraints (VRPTW‐S) that is well‐studied in literature. We present a Mixed Integer Programming method, and propose three Variable Neighborhood Search approaches. Extensive experiments show the effectiveness and efficiency of the General Variable Neighborhood Search with Ejection Chains‐based local search for solving VRPTW‐TD‐2MS and VRPTW‐S.
Functional role of RRS1 in breast cancer cell proliferation
Authors: Song Jinlian , Ma Zhongliang , Hua Yanan , Xu Junting , Li Ning , Ju Chuanxia , Hou Lin 
Published: October 2018

AbstractRRS1 (human regulator of ribosome synthesis 1), an essential nuclear protein involved in ribosome biogenesis, is overexpressed in some human cancers, yet its role in breast cancer remains unclear. Here, we report a functional analysis of RRS1 in breast cancer and its likely mechanism. Immunohistochemistry (IHC) and RT‐qPCR analyses indicated that RRS1 was commonly overexpressed in breast cancer tissues. The copy numbers of RRS1 were higher in tumours compared with those for normal tissues. And there was a significant correlation between copy number and mRNA expression. In addition, RRS1 overexpression was significantly correlated with lymph node metastasis and poor survival. RRS1 mRNA and protein levels were also significantly increased in a panel of human breast cancer cell lines. RRS1 knockdown inhibited proliferation and induced apoptosis and cell cycle arrest in all three cell lines. Furthermore, RRS1 knockdown suppressed the tumour formation and growth of MDA‐MB‐231 cells in nude mice. Additionally, RRS1 knockdown activated p53 and p21 in MCF‐7 cells. A marked increase in the quantity of ribosome‐free RPL11 was detected by Western blot. Moreover, co‐immunoprecipitation (CoIP) experiments showed that RRS1 knockdown activated p53 by facilitating the direct contact of MDM2 and RPL11/RPL5. Taken together, our results suggest that RRS1 may contribute to breast cancer proliferation through RPL11/MDM2‐mediated p53 activation. Therefore, RRS1 may be a promising target for breast cancer therapy.
Some of the effective factors in the pathogenesis of gastro‐oesophageal reflux disease
Authors: Nejat Pish‐Kenari Fatemeh , Qujeq Durdi , Maghsoudi Hossein 
Published: October 2018

AbstractOesophageal adenocarcinoma is one of the most fatal tumours to affect the digestive tract and is the eighth most common malignancy worldwide. Gastro‐oesophageal reflux has an important role in the incidence of adenocarcinoma of the oesophagus. Gastro‐oesophageal reflux disease (GERD) is a multifactorial, acid‐peptic disorder that results from the reflux of noxious material from the stomach into the oesophagus. The refluxed material causes the occurrence of oesophageal inflammation which creates a condition that is called reflux oesophagitis. The prevalence of this disease has increased dramatically in recent decades, mostly in the western world, where it affects about 10% to 30% of the population. The aetiology of oesophageal mucosal damage is complicated. Many inflammatory mediators are produced within the gastrointestinal (GI) tract, but their contributions in pathophysiology and disease pathogenesis have not been well investigated. Despite the protective barrier provided by the oesophageal mucosa, refluxed materials can cause oxidative injury and in?ammatory responses that involve the epithelium and immune cells. The analysing cellular events in gastro‐ oesophageal reflux disease and physiological responses to such conditions are important and necessary for a better grasp of the pathogenesis of GERD and the expansion of new treatments. Therefore, we want to discuss some of the important and key factors of GERD disease in this article.
Assessment of cognitive‐driven activity of daily living impairment in non‐demented Parkinson's patients
Authors: Becker Sara , Bäumer Alena , Maetzler Walter , Nussbaum Susanne , Timmers Maarten , Van Nueten Luc , Salvadore Giacomo , Zaunbrecher Detlev , Roeben Benjamin , Brockmann Kathrin , Streffer Johannes , Berg Daniela , Liepelt‐Scarfone Inga 
Published: October 2018

The core criterion for Parkinson's disease dementia (PDD) is the impairment in activities of daily living (ADL) function primarily caused by cognitive, not motor symptoms. There is evidence to assume that mild ADL impairments in mild cognitive impairment (PD‐MCI) characterize those patients at high risk for dementia. Data of 216 Parkinson's disease (PD) patients assessed with comprehensive motor and neuropsychological assessments were analysed. Based on linear regression models, subscores of the Functional Activities Questionnaire (FAQ) primarily reflecting patients’ global cognitive status (FAQC) or PD‐related motor severity (FAQM) were developed. A quotient (FAQQ) of both scores was calculated, with values >1 indicating more cognitive‐ compared to motor‐driven ADL impairment. Both FAQC and FAQM scores were higher in PD‐MCI than cognitively normal (PD‐CN) patients, indicating more severe cognitive‐ and motor‐driven ADL impairments in this group. One third (31.6%) of the PD‐MCI group had a FAQQ score >1, which was significantly different from patients with PD‐CN (p = .02). PD‐MCI patients with an FAQQ score >1 were more impaired on tests assessing attention (p = .019) and language (p = .033) compared to PD‐MCI patients with lower FAQQ values. The differentiation between cognitive‐ and motor‐driven ADL is important, as the loss of functional capacity is the defining factor for a diagnosis of PDD. We were able to differentiate the cognitive‐driven from the motor‐driven ADL impairments for the FAQ. PD‐MCI patients with more cognitive‐ compared to motor‐driven ADL impairments may pose a risk group for conversion to PDD and can be targeted for early treatments.
The Experience of Untapped Potential: Towards a Subjective Temporal Understanding of Work Meaningfulness
Authors: De Boeck Giverny , Dries Nicky , Tierens Hans 
Published: October 2018

AbstractIn this paper, we propose that untapped potential acts as a subjective temporal meaning‐making mechanism. Using a two‐wave survey design, we examine the relationship between job characteristics, untapped potential, and work meaningfulness in a heterogeneous sample of 542 employees. We found that employees’ perceived amount of untapped potential mediates the effects of skill variety, autonomy, and job feedback on work meaningfulness. This mediated relationship was moderated by the valence employees attributed to their untapped potential. Moreover, decreases in the perceived amount of untapped potential over time were related to increases in perceived work meaningfulness. Our research shows that work that allows employees to move beyond the here‐and‐now by providing opportunities to realize future work selves is experienced as particularly meaningful. We conclude that, if we wish to understand what makes work meaningful for employees in the present, we need to know how it aligns with their self‐perceptions in the future.
Body size trajectories and cardio‐metabolic resilience to obesity
Authors: Johnson W. 
Published: October 2018

AbstractIndividuals with obesity do not represent a single homogenous group in terms of cardio‐metabolic health prospects. The concept of metabolically healthy obesity is a crude way of capturing this heterogeneity and has resulted in a plethora of research linking to future outcomes to show that it is not a benign condition. By contrast, very few studies have looked back in time and modelled the life course processes and exposures that explain the heterogeneity in cardio‐metabolic health and morbidity and mortality risk among people with the same body mass index (BMI) (or waist circumference or percentage body fat). The aim of the Medical Research Council New Investigator Research Grant (MR/P023347/1) ‘Body size trajectories and cardio‐metabolic resilience to obesity in three United Kingdom birth cohorts’ is to reveal the body size trajectories, pubertal development patterns and other factors (e.g. early‐life adversity) that might attenuate the positive associations of adulthood obesity makers (e.g. BMI) with cardio‐metabolic disease risk factors and other outcomes, thereby providing some degree of protection against the adverse effects of obesity. This work builds on the Principle Investigator's previous research as part of the Cohort and Longitudinal Studies Enhancement Resources initiative and focuses on secondary data analysis in the nationally representative UK birth cohort studies (initiated in 1946, 1958 and 1970), which have life course body size and exposure data and a biomedical sweep in adulthood. The grant will provide novel evidence on the life course processes and exposures that lead to some people developing a cardio‐metabolic complication or disease or dying while other people with the same BMI do not. This paper details the grant's scientific rationale, research objectives and potential impact.
Optimising the identification of causal variants across varying genetic architectures in crops
Authors: Miao Chenyong , Yang Jinliang , Schnable James C. 
Published: October 2018

SummaryAssociation studies use statistical links between genetic markers and the phenotype variation across many individuals to identify genes controlling variation in the target phenotype. However, this approach, particularly conducted on a genome‐wide scale (GWAS), has limited power to identify the genes responsible for variation in traits controlled by complex genetic architectures. In this study, we employ real‐world genotype datasets from four crop species with distinct minor allele frequency distributions, population structures and linkage disequilibrium patterns. We demonstrate that different GWAS statistical approaches provide favourable trade‐offs between power and accuracy for traits controlled by different types of genetic architectures. FarmCPU provides the most favourable outcomes for moderately complex traits while a Bayesian approach adopted from genomic prediction provides the most favourable outcomes for extremely complex traits. We assert that by estimating the complexity of genetic architectures for target traits and selecting an appropriate statistical approach for the degree of complexity detected, researchers can substantially improve the ability to dissect the genetic factors controlling complex traits such as flowering time, plant height and yield component.
A metabolome‐based core hybridisation strategy for the prediction of rice grain weight across environments
Authors: Dan Zhiwu , Chen Yunping , Xu Yanghong , Huang Junran , Huang Jishuai , Hu Jun , Yao Guoxin , Zhu Yingguo , Huang Wenchao 
Published: October 2018

SummaryMarker‐based prediction holds great promise for improving current plant and animal breeding efficiencies. However, the predictabilities of complex traits are always severely affected by negative factors, including distant relatedness, environmental discrepancies, unknown population structures, and indeterminate numbers of predictive variables. In this study, we utilised two independent F1 hybrid populations in the years 2012 and 2015 to predict rice thousand grain weight (TGW) using parental untargeted metabolite profiles with a partial least squares regression method. A stable predictive model for TGW was built based on hybrids from the population in 2012 (r = 0.75) but failed to properly predict TGW for hybrids from the population in 2015 (r = 0.27). After integrating hybrids from both populations into the training set, the TGW of hybrids could be predicted but was largely dependent on population structures. Then, core hybrids from each population were determined by principal component analysis and the TGW of hybrids in both environments were successfully predicted (r > 0.60). Moreover, adjusting the population structures and numbers of predictive analytes increased TGW predictability for hybrids in 2015 (r = 0.72). Our study demonstrates that the TGW of F1 hybrids across environments can be accurately predicted based on parental untargeted metabolite profiles with a core hybridisation strategy in rice. Metabolic biomarkers identified from early developmental stage tissues, which are grown under experimental conditions, may represent a workable approach towards the robust prediction of major agronomic traits for climate‐adaptive varieties.
Evidence for the treatment of Talarodictyon tilesii as an older taxonomic synonym of Hydroclathrus stephanosorus (Scytosiphonaceae, Phaeophyceae)
Authors: Santiañez Wilfred John E. , Wynne Michael J. 
Published: October 2018

SUMMARYMorphological and anatomical evidence is presented to support the taxonomic judgment that Talarodictyon tilesii Endlicher is conspecific with Hydroclathrus stephanosorus Kraft in Kraft & Abbott. Because the former name has nomenclatural priority over the latter name, Hydroclathrus tilesii (Endlicher) comb. nov. is proposed.
The relation between blood donor recruitment and donor diversity and loyalty in the Netherlands
Authors: Piersma Tjeerd W. , Klinkenberg Elisabeth F. 
Published: October 2018

Background and ObjectivesBlood donor populations have been susceptible to change, often showing a trend towards feminization while remaining ethnically homogeneous, leading to an underrepresentation of young men and ethnic minorities. The aim of our study was to examine whether recruitment strategies are related to donor diversity and loyalty of specific demographic groups in the Netherlands.Materials and MethodsAnalyses were conducted using the Dutch blood donor database on whole‐blood donors registered between 2013 and 2017 (n = 155 054). Chi‐squared tests were used to study relationships between donor characteristics (i.e., sex, age, and Duffy‐negative antigen as proxy for donors from African descent) and recruitment strategies; linear and Cox regressions were used to study relationships between recruitment strategies, and number of donations and length of the donor career, respectively.ResultsMost donors were recruited via other donors (44·6%) or became donor on their own initiative (28·4%). Young men were often recruited by other donors and Duffy‐negative donors were often recruited via missing minorities campaigns. Donor‐recruits‐donor was associated with the highest number of donations; telephone recruitment was associated with the lowest number of donations. Although telephone recruitment was associated with the longest donor careers, it also showed the largest proportional stopping prevalence. Student recruitment and missing minorities campaigns were associated with the shortest donor careers.ConclusionOur results showed proportional differences in how people from different sex, age and ethnicity are recruited, and how recruitment relates to donor loyalty. We advocate for more personalized, evidence‐based recruitment and retention strategies.
Non‐electrocardiographic‐gated computed tomographic angiography can be used to diagnose coronary artery anomalies in Bulldogs with pulmonary valve stenosis
Authors: Gunther‐Harrington Catherine T. , Phillips Kathryn L. , Visser Lance C. , Fousse Samantha L. , Stern Joshua A. 
Published: October 2018

AbstractCoronary artery anomalies have been reported in Bulldogs and present an increased risk when performing balloon valvuloplasty. Identification of coronary anomalies has been reported using multidetector‐row computed tomographic (MDCT) angiography with electrocardiographic gating. However, the utility of non‐electrocardiographic‐gated 16‐row computed tomographic for MDCT for the identification of coronary artery anatomy or anomalies to the authors’ knowledge has not been fully investigated. The purpose of this study was to evaluate the feasibility of non‐electrocardiographic‐gated computed tomographic (CT) angiography to identify coronary anomalies in Bulldogs with pulmonary valve stenosis. In this prospective, observational study, Bulldogs with echocardiographically diagnosed pulmonary valve stenosis, an echocardiographically derived transpulmonic pressure gradient >70 mm Hg, and a clinician recommendation for balloon valvuloplasty were included. Anesthetized dogs underwent a 16‐row MDCT non‐electrocardiographic‐gated CT angiography. A board‐certified veterinary radiologist and board‐certified veterinary cardiologist reviewed the CT angiography studies and identified the coronary artery anatomy. When normal coronary artery anatomy was detected on CT angiography, a right ventricular outflow tract fluoroscopic angiogram was performed and evaluated during levophase to confirm normal coronary anatomy prior to balloon valvuloplasty. Dogs with coronary anomalies noted on CT angiography were recovered from anesthesia and balloon valvuloplasty was not performed. All dogs (10/10; 100%) had interpretable images from the non‐electrocardiographic‐gated CT angiography. Coronary anomalies were identified in six dogs based on non‐electrocardiographic‐gated CT angiography, five with type R2A anomaly and one had a single left coronary ostium. Four dogs had normal coronary anatomy based on non‐electrocardiographic‐gated CT angiography. Balloon valvuloplasty was performed without incident in these four dogs. We conclude that non‐electrocardiographic‐gated CT angiography represents a noninvasive method for diagnosing coronary anomalies in Bulldogs with pulmonary valve stenosis.
Comparison of the Quality of Pediatric Randomized Controlled Trials Published in Both Nursing and Medical Journals: Adherence to the CONSORT Statement
Authors: Devos Flora , Ibrahim Nour , Foissac Frantz , Bouazza Naim , Ancel Pierre‐Yves , Chappuy Hélène , Elie Caroline , Tréluyer Jean‐Marc 
Published: October 2018

AbstractBackgroundNursing care should be based on scientific evidence. However, studies must be performed rigorously with accurate reporting for their findings to be applicable to practice. Since the body of scientific nursing literature is broad, the quality and validity of its findings should be regularly controlled and verified to ensure their application and their practical impact.PurposeTo compare reporting quality of pediatric randomized controlled trial (RCT) articles in nursing and medical journals.MethodsRandomly selected articles were reviewed and scored to assess the number of CONSORT items that were adequately reported, generating a CONSORT score. The CONSORT scores for 28 items were compared between the two journal types.Results and DiscussionThe CONSORT scores by journal type were not significantly different: (19.2 [16.2; 22] for medical journals and 19.5 [16.1; 21.5] for nursing journals, p = .77). The reporting of CONSORT items was poor for both journal types. However, there were two significant differences: item 19 (Declaration of all important harm or unintended effects, p = .0006) and item 23 (Registration number of the study, p = .0003), were reported more often in medical journals. The adherence of journals to the CONSORT statement and large sample size was associated with better quality of the reporting of studies.ConclusionsBased on reporting quality, nursing studies have the same scientific credibility and rigor as medical studies in the pediatric field.Linking Evidence to ActionThe findings of this study could help researchers improve the reporting of their studies and highlight the importance of reporting quality for future knowledge transfer and practical use. The quality of research and its reporting is necessary to improve knowledge transfer into practice.
Continuous infusion versus intermittent bolus doses of fentanyl for analgesia and sedation in neonates: an open-label randomised controlled trial
Authors: Abiramalatha Thangaraj , Mathew Sumith Koshy , Mathew Binu Susan , Shabeer Machilakath Panangandi , Arulappan Geethanjali , Kumar Manish , Jayaseelan Visalakshi , Kuruvilla Kurien Anil 
Published: October 2018

ObjectiveAdequate data on fentanyl pharmacokinetics in neonates are lacking. The study was performed to compare serum concentrations and clinical outcome between continuous infusion (CI) and intermittent bolus (IB) doses of fentanyl for analgesia and sedation in neonates.MethodsIn this open-label randomised controlled trial, neonates requiring 24–48 hours of mechanical ventilation and fentanyl administration were recruited. In CI regimen, 1 mcg/kg loading dose was followed by 1 mcg/kg/hour infusion. In IB regimen, 1mcg/kg/dose was administered every 4 hours.Maximum six blood samples were collected in 48 hours from each baby at prespecified time points for estimating serum fentanyl concentration. Secondary outcomes were pain scores (Neonatal Infant Pain Scale and Neonatal Pain, Agitation and Sedation Scale for acute and ongoing pain, respectively) and incidence of adverse effects of fentanyl.Results100 neonates were recruited, 53 in CI and 47 in IB group. In CI regimen, median (IQR) serum fentanyl concentration was 0.42 (0.35, 0.46) to 0.61 (0.47, 0.89) ng/mL throughout the infusion period. In IB regimen, median (IQR) peak concentration ranged from 2.21 (1.82, 3.55) to 3.61 (2.91, 4.51) ng/mL and trough concentration 0.41 (0.33, 0.48) to 0.97 (0.56, 1.25) ng/mL for various doses.Median (IQR) peak concentration (Cmax, 3.06 (1.09, 4.50) vs 0.78 (0.49, 1.73) ng/mL; p<0.001) was significantly higher and area under concentration-time curve (AUC0–24, 19.6 (10.4, 33.5) vs 13.2 (10.8, 22.6) µg·hour/L; p=0.12) was higher (though not statistically significant) in IB than CI regimen. Pain scores and adverse effects were comparable between the two regimens.ConclusionCI regimen of fentanyl produces steady serum concentrations, whereas IB regimen produces wide fluctuations in serum concentration with high-peak concentrations. A serum fentanyl concentration of 0.4–0.6 ng/mL produces adequate analgesia and sedation in neonates.Trial registration numberCTRI/2014/11/005190.