bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural, Electrochemical and Hydrogen Sorption Studies of Nanocrystalline Ti-V-Co and Ti-V-Ni-Co Alloys Synthesized by Mechanical Alloying Method
Authors: Balcerzak M. 
Published: August 2019

Abstract
In this paper, Ti-V-Co and Ti-V-Ni-Co alloys are considered as the hydrogen storage systems and the negative electrodes in Ni-MH
x
secondary batteries. This work shows results of studies that have been made on Ti0.5V1.5−x
Co
x
and Ti0.5V1.4−x
Ni0.1Co
x
nanocrystalline alloys (x = 0, 0.1 0.2, 0.3) synthesized by the mechanical alloying technique. The goal of this study is to determine an effect of partial replacement of V by Co atoms on hydrogen storage and electrochemical properties of Ti-V and Ti-V-Ni alloys. X-ray diffraction studies have proven that 14 h of the ball milling has resulted in crystallization of body-centered-cubic solid solution. Studies performed on high-resolution transmission electron microscope confirm creation of nanocrystalline materials. Hydrogen sorption/desorption measurements that have been performed at 303 K show that Co accelerates the hydrogen sorption process, diminishes hysteresis and ameliorates the hydrogen storage reversibility. Properties of Ti-V-Co alloys, described in this work, originate mainly from structure of these materials. Electrochemical measurements of Ti-V-Co alloys have shown these materials poorly absorb hydrogen in 6 M KOH solution. Ti0.5V1.4−x
Ni0.1Co
x
alloys are characterized by better activation properties and improved cyclability in comparison to Co-free Ti0.5V1.4Ni0.1 alloy.
IBN AL-HAYTHAM, IBN SĪNĀ, AL-ṬŪSĪ : ÉGALITÉ OU CONGRUENCE
Authors: Rashed Roshdi 
Published: August 2019

AbstractAs their greek predecessors, mathematicians and arab-speaking philosophers raised several important epistemological questions. One of those questions concerns the concept of equality and the concept of congruence of geometric magnitudes. What was the meaning of such concepts? How were they related to the idea of movement? Answers to these questions were often combining metric elements and other, philosophical (topological) elements, and I chose to study those of a mathematician, of a philosopher, and of a mathematician-philosopher.
Spray mixture pH as affected by dicamba, glyphosate, and spray additives
Authors: Mueller Thomas C , Steckel Lawrence E 
Published: August 2019

AbstractThe pH of spray mixtures is an important attribute that affects dicamba volatility under field conditions. This report examined the effect of different components added to water sources that ranged in initial pH from 4.6 to 8.4. Commercial products were used, which include formulations of dicamba, glyphosate, the drift retardant Intact, ammonium sulfate (AMS), and several pH modifiers. Adding BAPMA salt of dicamba always increased the mixture pH, whereas diglycolamine + VaporGrip® (DGA+VG) had a mixed response. The addition of AMS decreased pH slightly (usually <0.5 pH unit), whereas the addition of potassium salt of glyphosate (GLY-K) always decreased the measured pH (from 1.0 to 2.1 pH units). A substantial pH change could have profound effects on dicamba volatility. Moreover, the 1.0 to 2.1 pH units would not be consistent with the registrant’s report stating that GLY-K decreased mixtures with DGA+VG pH by only 0.2 to 0.3 units. The drift retardant Intact had no effect on pH. There was no difference in resultant pH when comparing K salt and isopropylamine (IPA) salts of glyphosate. Spray carrier volume, ranging from 94 to 187 L ha–1, had only a minor effect on measured pH after the addition of various spray components. The addition of selected pH modifiers raised the pH above 5.0, which is a critical value according to the latest dicamba application labels. The order of mixing of various pH modifiers, including AMS, had only limited effect on measured spray solution pH.
MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling
Authors: Li Xiaowei , Lu Wen-Jing , Li Ya’nan , Wu Fujian , Bai Rui , Ma Shuhong , Dong Tao , Zhang Hongjia , Lee Andrew S. , Wang Yongming , Lan Feng 
Published: August 2019

AbstractMuscle LIM protein (MLP, CSRP3) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients. However, due to lack of human models, mechanisms underlining the pathogenesis of MLP defects remain unclear. In this study, we generated a knockout MLP/CSRP3 human embryonic stem cell (hESC) H9 cell line using CRISPR/Cas9 mediated gene disruption. CSRP3 disruption had no impact on the cardiac differentiation of H9 cells and led to confirmed MLP deficiency in hESC-derived cardiomyocytes (ESC-CMs). MLP-deficient hESC-CMs were found to develop phenotypic features of HCM early after differentiation, such as enlarged cell size, multinucleation, and disorganized sarcomeric ultrastructure. Cellular phenotypes of MLP-deficient hESC-CMs subsequently progressed to mimic heart failure (HF) by 30 days post differentiation, including exhibiting mitochondrial damage, increased ROS generation, and impaired Ca2+ handling. Pharmaceutical treatment with beta agonist, such as isoproterenol, was found to accelerate the manifestation of HCM and HF, consistent with transgenic animal models of MLP deficiency. Furthermore, restoration of Ca2+ homeostasis by verapamil prevented the development of HCM and HF phenotypes, suggesting that elevated intracellular Ca2+ concentration is a central mechanism for pathogenesis of MLP deficiency. In summary, MLP-deficient hESC-CMs recapitulate the pathogenesis of HCM and its progression toward HF, providing an important human model for investigation of CSRP3/MLP-associated disease pathogenesis. More importantly, correction of the autonomous dysfunction of Ca2+ handling was found to be an effective method for treating the in vitro development of cardiomyopathy disease phenotype.
Aurora-A/ERK1/2/mTOR axis promotes tumor progression in triple-negative breast cancer and dual-targeting Aurora-A/mTOR shows synthetic lethality
Authors: Zhang Wenfeng , Xia Ding , Li Zhangyun , Zhou Tao , Chen Tingting , Wu Zhengping , Zhou Weihua , Li Zilun , Li Longkun , Xu Jie 
Published: August 2019

Abstract
Triple-negative breast cancer (TNBC), defined as a tumor subtype that lacks ER, PR, and HER2, shows a poor prognosis due to its aggressive tumor biology and limited treatment options. Deregulation of Aurora kinase A (Aur-A), a member of the mitotic serine/threonine Aurora kinase family, and overactivation of the mTOR pathway commonly occur in multiple cancer types. We previously found that Aur-A activated the mTOR pathway and inhibited autophagy activity in breast cancer cell models. Whether and how Aur-A regulates mTOR in TNBC are still unclear. Here, we found that Aur-A and p-mTOR are highly expressed and positively associated with each other in TNBC cells and tissues. Inhibition or knockdown of Aur-A decreased p-mTOR and suppressed cell proliferation and migration, whereas overexpression of Aur-A increased p-mTOR levels and promoted cell proliferation and migration, which was significantly abrogated by simultaneous silencing of mTOR. Intriguingly, overexpression of Aur-A enhanced the expression of p-mTOR and p-ERK1/2, and silencing or inhibition of ERK1/2 blocked Aur-A-induced p-mTOR. However, silencing or inhibition of mTOR failed to reverse Aur-A-induced ERK1/2, indicating that Aur-A/ERK1/2/mTOR forms an oncogenic cascade in TNBC. We finally found that double inhibition of Aur-A and mTOR showed significant synergistic effects in TNBC cell lines and a xenograft model, indicating that Aur-A and mTOR are potential therapeutic targets in the TNBC subtype.
The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death
Authors: El-Mesery Mohamed , Rosenthal Tina , Rauert-Wunderlich Hilka , Schreder Martin , Stühmer Thorsten , Leich Ellen , Schlosser Andreas , Ehrenschwender Martin , Wajant Harald , Siegmund Daniela 
Published: August 2019

AbstractThe NEDD8-activating enzyme (NAE) inhibitor MLN4924 inhibits cullin-RING ubiquitin ligase complexes including the SKP1-cullin-F-box E3 ligase βTrCP. MLN4924 therefore inhibits also the βTrCP-dependent activation of the classical and the alternative NFĸB pathway. In this work, we found that a subgroup of multiple myeloma cell lines (e.g., RPMI-8226, MM.1S, KMS-12BM) and about half of the primary myeloma samples tested are sensitized to TNF-induced cell death by MLN4924. This correlated with MLN4924-mediated inhibition of TNF-induced activation of the classical NFκB pathway and reduced the efficacy of TNF-induced TNFR1 signaling complex formation. Interestingly, binding studies revealed a straightforward correlation between cell surface TNFR1 expression in multiple myeloma cell lines and their sensitivity for MLN4924/TNF-induced cell death. The cell surface expression levels of TNFR1 in the investigated MM cell lines largely correlated with TNFR1 mRNA expression. This suggests that the variable levels of cell surface expression of TNFR1 in myeloma cell lines are decisive for TNF/MLN4924 sensitivity. Indeed, introduction of TNFR1 into TNFR1-negative TNF/MLN4924-resistant KMS-11BM cells, was sufficient to sensitize this cell line for TNF/MLN4924-induced cell death. Thus, MLN4924 might be especially effective in myeloma patients with TNFR1+ myeloma cells and a TNFhigh tumor microenvironment.
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
Authors: Chua Adeline C. Y. , Ong Jessica Jie Ying , Malleret Benoit , Suwanarusk Rossarin , Kosaisavee Varakorn , Zeeman Anne-Marie , Cooper Caitlin A. , Tan Kevin S. W. , Zhang Rou , Tan Bee Huat , Abas Siti Nurdiana , Yip Andy , Elliot Anne , Joyner Chester J. , Cho Jee Sun , Breyer Kate , Baran Szczepan , Lange Amber , Maher Steven P. , Nosten François , Bodenreider Christophe , Yeung Bryan K. S. , Mazier Dominique , Galinski Mary R. , Dereuddre-Bosquet Nathalie , Le Grand Roger , Kocken Clemens H. M. , Rénia Laurent , Kyle Dennis E. , Diagana Thierry T. , Snounou Georges , Russell Bruce , Bifani Pablo 
Published: August 2019

AbstractThe ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodium falciparum revolutionized research on this important parasite. However, for P. vivax, the most widely distributed and difficult to treat malaria parasite, a strict preference for reticulocytes thwarts efforts to maintain it in vitro. Cultivation of P. cynomolgi, a macaque-infecting species phylogenetically close to P. vivax, was briefly reported in the early 1980s, but not pursued further. Here, we define the conditions under which P. cynomolgi can be adapted to long term in vitro culture to yield parasites that share many of the morphological and phenotypic features of P. vivax. We further validate the potential of this culture system for high-throughput screening to prime and accelerate anti-P. vivax drug discovery efforts.
Smart machine learning or discovering meaningful physical and chemical contributions through dimensional stacking
Authors: Griffin Lee A. , Gaponenko Iaroslav , Zhang Shujun , Bassiri-Gharb Nazanin 
Published: August 2019

AbstractDespite remarkable advances in characterization techniques of functional materials yielding an ever growing amount of data, the interplay between the physical and chemical phenomena underpinning materials’ functionalities is still often poorly understood. Dimensional reduction techniques have been used to tackle the challenge of understanding materials’ behavior, leveraging the very large amount of data available. Here, we present a method for applying physical and chemical constraints to dimensional reduction analysis, through dimensional stacking. Compared to traditional, uncorrelated techniques, this approach enables a direct and simultaneous assessment of behaviors across all measurement parameters, through stacking of data along specific dimensions as required by physical or chemical correlations. The proposed method is applied to the nanoscale electromechanical relaxation response in (1 − x)PMN-xPT solid solutions, enabling a direct comparison of electric field- and chemical composition-dependent contributors. A poling-like, and a relaxation-like behavior with a domain glass state are identified, and their evolution is tracked across the phase diagram. The proposed dimensional stacking technique, guided by the knowledge of the underlying physics of correlated systems, is valid for the analysis of any multidimensional dataset, opening a spectrum of possibilities for multidisciplinary use.
A continuum study of layer analysis for single species ion transport inside double-layered graphene sheets with various separations
Authors: Chan Yue , Saeed Muhammad , Lee Shern-Long , Wylie Jonathan J. 
Published: August 2019

AbstractWe investigate the formation of thin ionic layers driven by electro-osmotic forces, that are commonly found in micro- and nano-channels. Recently, multi-layers have been reported in the literature. However, the relation between classical Debye layers and multi-layers, which is a practically and fundamentally important question, was previously unexplained. Here, we fill this gap by using a continuum approach to investigate the flow of lithium ions inside double-layered graphene sheets. Fluid flow, charge conductivity and thermal stability will be investigated. We show that the separation and strength of forces between the sheets, the external electric field and thermal effects determine the topology of the ionic layers between the graphene sheets.
Strip rotary tillage with a two-year subsoiling interval enhances root growth and yield in wheat
Authors: He Jianning , Shi Yu , Zhao Junye , Yu Zhenwen 
Published: August 2019

AbstractExcessive tillage and soil compaction threaten the sustainable farmlands in the Huang-Huai-Hai Plains of China. Our study explores tillage practices to improve soil and root ecology and promote productivity in the winter wheat fields. We tested the impact of plowing, rotary, strip rotary tillage and strip rotary tillage with a two-year subsoiling interval (SRS) on wheat yield and root quality. SRS decreased soil bulk density compared with other treatments, resulting in lower soil penetration resistance. Root morphology and weight density decreased with the increased soil depth and was higher in SRS. Moreover, SRS increased the indoleacetic acid and trans zeatin riboside levels corresponding to greater TTC reduction activities, the total and active absorption root area. SRS increased the superoxide dismutase and catalase activities and soluble protein concentration and decreased the malondialdehyde concentration. The first two factors extracted using 11 root attributes in various soil layers through principal component analysis were selected as the integrated indicators for the minimum data set, and their integrated score was calculated to quantify the root quality. Our study suggests that SRS could significantly improve root morphology and enhance the root activity in subsoil layers, thus, delaying root senescence and increasing winter wheat yield.
Genome-wide Identification, Classification, Expression and Duplication Analysis of GRAS Family Genes in Juglans regia L.
Authors: Quan Shaowen , Niu Jianxin , Zhou Li , Xu Hang , Ma Li , Qin Yang 
Published: August 2019

AbstractFifty-two GRAS genes are identified in walnut genome. Based on the evolutionary relationship and motif analysis, the walnut GRAS gene family was divided into eight subfamilies, and the sequence features analysis of JrGRAS proteins showed that the JrGRAS protein sequences were both conserved and altered during the evolutionary process. Gene duplication analysis indicated that seven GRAS genes in walnut have orthologous genes in other species, and five of them occurred duplicated events in walnut genome. Expression pattern analysis of the GRAS family genes in walnut showed that two JrGRAS genes (JrCIGRa-b and JrSCL28a) were differentially expressed between flower bud and leaf bud (p < 0.01), and two JrGRAS genes (JrCIGRa-b and JrSCL13b-d) were differentially expressed between the different development stages of flower buds transition (p < 0.01), besides, three hub genes (JrGAIa, JrSCL3f and JrSHRc) were identified by co-expression analysis, which suggested these GRAS genes may play an important role in regulating the development of apical meristem in walnut. This study laid a foundation for further understanding of the function of GRAS family genes in walnut.
Improved culture of fastidious Gemmata spp. bacteria using marine sponge skeletons
Authors: Kaboré Odilon D. , Godreuil Sylvain , Drancourt Michel 
Published: August 2019

AbstractGemmata are Planctomycetes bacteria recalcitrant to traditional cultivation in the clinical microbiology laboratory and they have been seldom documented in patients. Based on previously known relationships of Planctomycetes with marine sponges, we designed a new culture medium A incorporating marine sponge skeleton of Spongia sp. to the standard culture medium; and culture medium B incorporating Spongia sp. skeleton heat aqueous filtrate into medium A; and inoculating the three culture media (standard, A and B) with Gemmata obscuriglobus DSM 5831T and Gemmata massiliana DSM 26013T in the presence of negative controls. Cultures were observed by naked eyes for 7 days and bacterial growth was quantified by microscopic observations and culture-based enumerations. Macroscopic observations at day-3 revealed a pink bacterial pellet in medium B tubes while standard medium tubes remained limpid until day-8. Growing Gemmata spp. bacteria in medium A yielded air bubbles released by bacterial respiration, whereas control tubes remained bubble-free. The number of colonies in standard medium (1.363 ± 115 for G. obscuriglobus, 1.288 ± 83 for G. massiliana) was significantly lower than those counted from medium B (2.552 ± 128 for G. obscuriglobus, 1.870 ± 112 for G. massiliana) and from medium A (2.851 ± 137 for G. obscuriglobus, 2.035 ± 163 for G. massiliana) (p < 0.10−4) at day-2 incubation. At day-3 incubation, the number of colonies counted from supplemented media A and B increased up to one log than those counted from the control medium (p < 0.10−4). Along the following day-4–7 incubation, the number of colonies counted from media A and B remained significantly higher compared to standard medium (p < 0.10−4). These data indicate that incorporation of spongin-based marine sponge skeleton and heat aqueous filtrate of sponge skeleton significantly improved growth of Gemmata spp. bacteria. These observations pave the way towards improved isolation and culture of Gemmata spp. from environmental and clinical specimens.
Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) – Part 1 with Recommendations on the Epidemiology, Etiology, Prediction, Primary and Secondary Prevention of Preterm Birth
Authors: Berger Richard , Abele Harald , Bahlmann Franz , Bedei Ivonne , Doubek Klaus , Felderhoff-Müser Ursula , Fluhr Herbert , Garnier Yves , Grylka-Baeschlin Susanne , Helmer Hanns , Herting Egbert , Hoopmann Markus , Hösli Irene , Hoyme Udo , Jendreizeck Alexandra , Krentel Harald , Kuon Ruben , Lütje Wolf , Mader Silke , Maul Holger , Mendling Werner , Mitschdörfer Barbara , Nicin Tatjana , Nothacker Monika , Olbertz Dirk , Rath Werner , Roll Claudia , Schlembach Dietmar , Schleußner Ekkehard , Schütz Florian , Seifert-Klauss Vanadin , Steppat Susanne , Surbek Daniel 
Published: August 2019

Abstract
Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recent scientific literature, the experience of the members of the guideline commission and the views of self-help groups.
Methods Based on the international literature, the members of the participating medical societies and organizations developed Recommendations and Statements. These were adopted following a formal process (structured consensus conference with neutral moderation, voting was done in writing using the Delphi method to achieve consensus).
Recommendations Part I of this short version of the guideline lists Statements and Recommendations on the epidemiology, etiology, prediction and primary and secondary prevention of preterm birth.
Metal-Catalyzed Site-Selective Monoacylation of Diols in Aqueous Media
Authors: Li Yuyang , Kluger Ronald 
Published: August 2019

Site-selective reactions of water-soluble biomolecules are being developed to produce efficient conversions in water and water­/solvent mixtures. This review focuses on the use of designs based on bis-bidentate chelation of large metal ions by diols to be acylated by a co-chelated water-stable reagent. Topics discussed include: 1. The preparation and properties of water-stable acyl phosphate monoesters and their reactions with diol-chelated metal ions. 2. Site-selective monoaminoacylation of 3′-terminal diols of RNA and their applications in protein engineering. 3. Site-selective monoacylation of sugars with acyl phosphate monoesters associated with metal ions, including lanthanum and lead. The combination of metal ion, 1,2-diol, and acyl phosphate monoester produces site-selective reactions in aqueous media­ that can produce a general approach to site-selective mono-(amino)acylation in RNA and carbohydrates.1	Introduction2	Synthetic Aminoacylation of tRNA3	Activated Amino Acids in Water4	Metal Ions and Their Effects on the Reactivity of Acyl Phosphate
Monoesters5	The Challenge of Site-Selective Acylation of Carbohydrates in
Water6	Conclusions and Prospects
Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles
Authors: Saha Amit K. , Zhen Min-Yi S. , Erogbogbo Folarin , Ramasubramanian Anand K. 
Published: August 2019

AbstractNanoparticles have numerous biomedical applications including, but not limited to, targeted drug delivery, diagnostic imaging, sensors, and implants for a wide range of diseases including cancer, diabetes, heart disease, and tuberculosis. Although the mode of delivery of the nanoparticles depends on the application and the disease, the nanoparticles are often in immediate contact with the systemic circulation either because of intravenous administration or their ability to enter the bloodstream with relative ease or their longer survival time in circulation. Once in circulation, the nanoparticles may elicit unintended hemostatic and inflammatory responses, and hence the design of nanoparticles for therapeutic applications should take broad hemocompatibility concerns into consideration. In this review, we present the principles underlying the structural and functional design of various classes of nanoparticles that are currently approved by the US Food and Drug Administration, categorize these particles based on their interactions with cardiovascular tissues and ensuing adverse events, and also describe various in vitro assays that may be used evaluate their hemocompatibility.