bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyaluronic High Definition Fill Technique
Authors: Lourenço Luciana M. , Di Sessa David , Tebet Ana Carolina Franco , de Noronha Maria Gabriela Ortiz , de Medeiros Helena Lourenço , Sigrist Rosa 
Published: November 2024

ABSTRACTIntroductionAchieving a defined abdomen through traditional surgical methods like liposuction and abdominoplasty involves risks and significant downtime. Hyaluronic acid (HA) body filling has emerged as a minimally invasive alternative, offering immediate results with reduced recovery periods.Patients and MethodsThe high‐definition abdomen through HA technique (HHD) was implemented on young men with BMI < 24.9, excluding those with obesity or excessive skin laxity. HA gel with large particle sizes (800–1800 μm) and high G prime was chosen based on subcutaneous thickness. Injections were guided by ultrasound into the lamellar fat layer between Camper's fascia and Scarpa's fascia, targeting abdominal metameres for enhancement. Participants completed the Global Aesthetic Improvement Scale.ResultsThe technique produced satisfactory outcomes, enhancing abdominal metamere definition. Mild post‐procedural hematomas and transient discomfort were noted. At 10 months, 71.4% of patients reported “much improved,” and 28.6% reported “improved,” per the GAIS questionnaire.DiscussionCustomizing HA characteristics and employing ultrasound guidance ensured safe and precise injections, minimizing vascular risks. Limitations such as HA's temporary nature and exclusions for surgical candidates were acknowledged.ConclusionHHD using large particle HA proved effective in achieving aesthetic abdominal enhancements with minimal risks and downtime. This technique not only provided immediate results but also contributed to enhanced patient satisfaction and self‐esteem. Further research is needed to explore broader applications and refine outcomes across diverse patient groups.
Governing Inter‐Organizational Collaboration through Purpose Work and Purpose Borrowing: How Social Enterprises' Normative Aspirations Influence Business Partners' Practices
Authors: Bruder Ignas M. , Sydow Jörg 
Published: November 2024

AbstractSocial enterprises may boost their impact by convincing collaborating businesses to contribute to their purposes. However, such enterprises typically lack the leverage to influence mainstream businesses. We investigate to what extent their abundant social resources might enable them to remedy this weakness to some extent. Taking a practice‐based perspective, we conduct an ethnographic case study of a social enterprise's collaborative relationships. We discover a collaboration process grounded in social purpose: If a social enterprise's underlying normative aspiration is to put ‘purpose before profit’ and it practices ‘purpose work’, its partners may conversely engage in ‘purpose borrowing’, which involves actions espousing the social enterprise's purpose even if they go against business common sense. We advance research on hybrid organizations by explaining how social enterprises can exert a significant degree of influence on their business partners thanks to their inherent social resources, which are more diverse and powerful than assumed so far. Furthermore, we contribute to inter‐organizational collaboration research by identifying a new mode of relational governance founded on social purpose that goes beyond the established modes based on legitimacy, trust, and reciprocity.
New mid‐Cretaceous macrothelids showing a similar living mode to extant Macrothelidae (Araneae: Mygalomorphae)
Authors: Wang Xuying , Yu Kun , Selden Paul A. , Ren Dong , Guo Xiangbo 
Published: November 2024

AbstractFive new spider fossils of the family Macrothelidae (Araneae: Mygalomorphae) are described from mid‐Cretaceous Kachin amber, Myanmar. A new genus Acanthomacrothele gen. nov. is established for three new species: Acanthomacrothele pauciverrucae sp. nov., Acanthomacrothele geminata sp. nov., and Acanthomacrothele longicaudata sp. nov. Both male and female specimens of A. pauciverrucae sp. nov. are described, representing a rare case of a fossil spider with both sexes known. We also describe an unidentified juvenile of Macrothelidae to document different developmental stages of Cretaceous species. To test the phylogenetic position of the new fossils, we undertook phylogenetic analyses using both topology‐unconstrained and topology‐constrained methods. Our analyses supported the placement of Acanthomacrothele gen. nov. in Macrothelidae, although its phylogenetic relationship to other genera of Macrothelidae differed among different analytical methods. The fossils documented here have elongated, widely spaced posterior lateral spinnerets, compact rectangular group of eyes on a tubercle, and more spines on male tibia of anterior legs than female, similar to extant macrothelids, suggesting that they probably have similar retreat construction behavior, habitat preference, and mating position to their living relatives.
An Exploration Into the Measurement and Reporting of Food Firmness and Hardness
Authors: Rosenthal Andrew J. 
Published: November 2024

ABSTRACTHardness is a commonly reported food property, measured by compression at a high strain where the food structure breaks. Hardness should not be reported for foods that deform without breaking. Firmness is an intermediate level of hardness associated with nondestructive compression, at strains typically around 0.1. Sensory perception enables accurate classifications of hardness. Conversely (and perhaps counterintuitively), instrumental measurements of hardness while often precise are not necessarily accurate. The outcome depending on the test protocol, whereby the geometry of the test apparatus, the speed of the test and the degree of deformation all influence the result. Ambiguity occurs in how instrumental measurements of hardness are reported, with some authors using stress, while others use force.
Ninja turtles: an experimental evaluation of potential anthropogenic barriers to movement for a freshwater turtle
Authors: Dowling J. M. , Bower D. S. , Nordberg E. J. 
Published: November 2024

AbstractAnthropogenic landscape change due to urbanization, agriculture, and resource extraction results in barriers within the landscape. Artificial structures such as roads, fences, levees, and dams limit the movement of some species and further fragment residual habitat. In this study, we investigated the ability of Eastern long‐necked turtles (Chelodina longicollis) to cross various terrestrial obstacles commonly encountered throughout their habitat. We tested two types of fences (chicken wire and hinged joint exclusion fencing) commonly used in agricultural systems and three sizes of rocks (gravel, cobbles, and boulders) often used for road construction, erosion control, and waterway stabilization. We examined the success rates of turtles in crossing obstacles, the effect of fatigue on crossing attempts, and the impact of individual boldness on movement behaviour. Turtles had high success rates in crossing gravel (85.4%), cobbles (86%), boulders (73.3%) and hinged joint exclusion fencing (94.7%). Turtles did not successfully cross chicken wire fencing (0%) despite 276 attempts. A significant fatigue effect occurred throughout the experiment, with turtles making an average of 3.94 (±1.42 SE) fewer attempts at the end of the experiment (day 18) than on day 1. Bolder turtles were faster at crossing obstacles, but boldness had no influence on obstacle‐crossing success. Our results highlight the need for thoughtful selection of waterway, wetland, and riparian bordering infrastructure and the fatiguing impact of constant exposure to anthropogenic barriers for wildlife.
Feeding ecology of two wild sympatric canids in protected areas of northeastern Argentina
Authors: Bay‐Jouliá R. , Romero V. L. , Natalini M. B. , Kowalewski M. M. 
Published: November 2024

AbstractThe role of mesocarnivores in wildlife communities tends to be overlooked, which has led to a large gap in natural history knowledge. In northeastern Argentina, two mesocarnivore foxes, Cerdocyon thous and Lycalopex gymnocercus, live in sympatry in noncompetitive coexistence. Their feeding habits have been studied in many occasions; however, the studies related to trophic variability in a wider spatial scale remain scarce. In this study, we aimed to analyze how the diet of these foxes varies in three protected areas in Argentina: the Mburucuyá National Park (MNP), the “San Nicolás Portal” (SN), and the Natural Reserve Rincón de Santa María (RSM). We collected fecal samples in each area, identified them using thin layer chromatography at species level, and classified the found feeding items to obtained two parameters: occurrence and relative frequency. Furthermore, we compared the diet of the two species in each site and between sites using chi‐square and estimated trophic niche breadth and overlap between the species. We found that both species consumed different food categories, with variable frequencies across study sites. We observed that in each area, the foxes differed in diet composition. However, we found no differences between the diet compositions of C. thous and L. gymnocercus, showing high niche overlap in each site. Here, we show the plasticity of both fox species in changing their diets even with small geographical variation. Both species can coexist even with a high diet overlap, possibly explained by their noncompetitive coexistence which may occur due to the current changes in the ecosystem interactions, or partitioning may exist but on a smaller niche level.
A multi‐perspective fusion model for operating speed prediction on highways using knowledge‐enhanced graph neural networks
Authors: Gao Jianqiang , Yu Bo , Chen Yuren , Gao Kun , Bao Shan 
Published: November 2024

AbstractThis study proposes a multi‐perspective fusion model for operating speed prediction based on knowledge‐enhanced graph neural networks, named RoadGNN‐S. By utilizing message passing and multi‐head self‐attention mechanisms, RoadGNN‐S can effectively capture the coupling impacts of multi‐perspective alignment elements (i.e., two‐dimensional design, 2.5‐dimensional driving, and three‐dimensional spatial perspectives). The results of driving simulation data show that root mean squared error, mean absolute error, mean absolute percentage error, and R‐squared values of RoadGNN‐S are superior to those of other classic deep learning algorithms. Then, prior knowledge (i.e., highway geometry supply, driver expectations, and vehicle dynamics) is introduced into RoadGNN‐S, and the models’ prediction accuracy and transferability are verified by field observation experiments. Compared to the above data‐driven models, knowledge‐enhanced RoadGNN‐S effectively avoids the fundamental errors, improving the R‐squared value in predicting passenger cars’ and trucks’ operating speed by 7.9% and 10.7%, respectively. The findings of this study facilitate the intelligent highway geometric design with multi‐perspective fusion and knowledge enhancement techniques.
Exploring the Caregiver Experiences of Symptom Management in Children With Cancer: A Qualitative Systematic Review
Authors: Whalan Ethan , Skrabal Ross Xiomara , Bowers Alison , Bradford Natalie 
Published: November 2024

ABSTRACTAlthough caregivers of children with cancer play an instrumental role in managing their child's symptoms, the impact of their own experiences or perspectives is under‐explored. Understanding these factors is essential as they influence caregiving behaviors and overall well‐being. This qualitative systematic review addresses this knowledge gap by synthesizing existing research on caregiver's experiences. The review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Two reviewers utilized Rayyan to screen titles and abstracts retrieved from comprehensive keyword searches of five databases including CINAHL, APA PsycINFO, Embase, and MEDLINE. Databases and bibliographies were hand‐searched for additional articles. One reviewer completed full text assessment and data were extracted into an Excel spreadsheet. The Quality Assessment with Diverse Studies tool was used to appraise included studies. Thematic content analysis was used to synthesize findings, which are presented narratively. Twelve articles are included, representing the experiences of 597 caregivers, most of which (83%) were undertaken in high‐income nations. Quality appraisal scores indicated all studies were of moderate to robust quality. Three main themes were identified including: (1) caregivers as protectors in their role, (2) normalization of symptoms yet they remain disrupting, and (3) communication between the caregiver and child. Findings emphasize the importance of formalized information provision and education to better support caregivers in managing their child's cancer‐related symptoms. Nurses are uniquely positioned to provide this essential support thereby improving the quality of life for both caregivers and children.
A style guide for the structuralist
Authors: Carr Lucy 
Published: November 2024

AbstractOntic structuralists claim that there are no individual objects, and that reality should instead be thought of as a “web of relations”. It is difficult to make this metaphysical picture precise, however, since languages usually characterize the world by describing the objects that exist in it. This paper proposes a solution to the problem; I argue that when discourse is reformulated in the language of the calculus of relations ‐ an algebraic logic developed by Alfred Tarski ‐ it can be interpreted without presupposing the existence of objects. What is distinctive about the language of the calculus is that it contains no operator that resembles a quantifier, and yet it can be used to paraphrase any sentence expressible in first‐order logic. Since the use of a first‐order quantifier (or some similar operator) is usually what establishes commitment to an ontology of objects, and since the calculus of relations eschews the quantifier in favor of a composition operator that can be given a natural interpretation consistent with structuralist metaphysics, the calculus is an ideal language for the structuralist to use to describe the world.
MicroRNA399s and strigolactones mediate systemic phosphate signaling between dodder‐connected host plants and control association of host plants with rhizosphere microbes
Authors: Zhao Man , Zheng Xijie , Su Zhongxiang , Shen Guojing , Xu Yuxing , Feng Zerui , Li Wenxing , Zhang Shuhan , Cao Guoyan , Zhang Jingxiong , Wu Jianqiang 
Published: November 2024

Summary
A dodder (Cuscuta) often simultaneously parasitizes two or more adjacent hosts. Phosphate (Pi) deficiency is a common stress for plants, and plants often interact with soil microbes, including arbuscular mycorrhizal fungi (AMF), to cope with Pi stress. Little is known about whether dodder transmits Pi deficiency‐induced systemic signals between different hosts.
In this study, dodder‐connected plant clusters, each composed of two tobacco (Nicotiana tabacum) plants connected by a dodder, were established, and in each cluster, one of the two tobacco plants was treated with Pi starvation. AMF colonization efficiency, rhizosphere bacterial community, and transcriptome were analyzed in the other dodder‐connected Pi‐replete tobacco plant to study the functions of interplant Pi signals.
We found that dodder transfers Pi starvation‐induced systemic signals between host plants, resulting in enhanced AMF colonization, changes of rhizosphere bacterial communities, and alteration of transcriptomes in the roots of Pi‐replete plants. Importantly, genetic analyses indicated that microRNA399s (miR399s) and strigolactones suppress the systemic Pi signals and negatively affect AMF colonization in the Pi‐replete plants.
These findings provide new insight into the ecological role of dodder in mediating host–host and host–microbe interactions and highlight the importance of strigolactone and miR399 pathways in systemic Pi signaling.
Developmental constraint underlies the replicated evolution of grass awns
Authors: Patterson Erin , MacGregor Dana R. , Heeney Michelle M. , Gallagher Joseph , O'Connor Devin , Nuesslein Benedikt , Bartlett Madelaine Elisabeth 
Published: November 2024

Summary
Replicated trait evolution can provide insights into the mechanisms underlying the evolution of biodiversity. One example of replicated evolution is the awn, an organ elaboration in grass inflorescences.
Awns are likely homologous to leaf blades. We hypothesized that awns have evolved repeatedly because a conserved leaf blade developmental program is continuously activated and suppressed over the course of evolution, leading to the repeated emergence and loss of awns. To evaluate predictions arising from our hypothesis, we used ancestral state estimations, comparative genetics, anatomy, and morphology to trace awn evolution.
We discovered that awned lemmas that evolved independently share similarities in developmental trajectory. In addition, in two species with independently derived awns and differing awn morphologies (Brachypodium distachyon and Alopecurus myosuroides), we found that orthologs of the YABBY transcription factor gene DROOPING LEAF are required for awn initiation. Our analyses of awn development in Brachypodium distachyon, Alopecurus myosuroides, and Holcus lanatus also revealed that differences in the relative expansion of awned lemma compartments can explain diversity in awn morphology at maturity.
Our results show that developmental conservation can underlie replicated evolution and can potentiate the evolution of morphological diversity.
Mechanisms Underlying Medication‐Related Osteonecrosis of the Jaw
Authors: Lee Kyeongho , Kim Kihun , Kim June Yeon , Kim Jin‐Woo , Kang Young‐Hoon , Kim Yun Hak , Kim Sung‐Jin 
Published: November 2024

ABSTRACTObjectiveMedication‐related osteonecrosis of the jaw (MRONJ) is a rare but debilitating disease characterized by a progressive necrosis of jaw bones in patients who have received anti‐resorptive or anti‐angiogenic therapies. Unfortunately, we still have no validated preventive or pharmaceutical interventions to help these patients, primarily due to our limited understanding of MRONJ pathogenesis. Here, we offer an extensive review of recent studies relevant to MRONJ pathogenesis. We present a hypothesis regarding the coupling of bone resorption and angiogenesis that relies on osteoblast‐derived, matrix‐bound vascular endothelial growth factors to explain why ONJ is associated with both anti‐resorptive and anti‐angiogenic agents.MethodsA narrative review was conducted by searching databases, including PubMed, Scopus, Google Scholar, and Web of Science, to retrieve relevant reports.ResultsReduced bone resorption leads to reduced angiogenesis, and vice versa, creating a vicious cycle that ultimately results in ischemic necrosis of the jaw. Additionally, we suggest that reduced angiogenesis, induced by anti‐resorptive or anti‐angiogenic agents, aggravates bacterial infection‐induced bone necrosis, explaining why the jaw bone is particularly susceptible to necrosis.ConclusionOur novel hypothesis will facilitate the advancement of future research and the development of more targeted approaches to managing MRONJ.
Management of patients at risk of harms from both continuing and discontinuing their long‐term opioid therapy: A qualitative study to inform the gap in clinical practice guidelines
Authors: Timko Christine , Lor Mai Chee , Kertesz Stefan , Kroenke Kurt , Macia Kathryn , Nevedal Andrea , Hoggatt Katherine J. 
Published: November 2024

AbstractBackgroundAlthough long‐term opioid therapy (LTOT) for chronic pain has declined, it remains common in the U.S. Providers do not have clinical practice guidelines for vulnerable LTOT patients, in whom both LTOT continuation and tapering to discontinuation pose risks of harm and in whom opioid use disorder (OUD) is absent.MethodsTo begin to meet the gap in guidelines, the study used a multiple case study approach. Five cases were constructed to systematically vary key elements of LTOT continuation and discontinuation harms among patients reporting LTOT's lack of efficacy (experience of pain and poor function). For each, treatment approaches were collected from 28 opioid safety experts identified through their participation in a national policy panel (19 were physicians) and analyzed using template analysis.ResultsFor patients receiving LTOT with harms of continuation and discontinuation, experts recommended attempting a slow taper (even with a prior unsuccessful taper, possibly with adjuvant medications to manage withdrawal) and not maintaining opioid therapy. Experts considered switching to buprenorphine, especially if the patient had aberrant behaviors. They also considered adding non‐opioid pain therapies (especially re‐trying such therapies if they were unhelpful before) and engaging in shared decisionmaking, although with little consensus on specific approaches. Some experts would address co‐occurring conditions related to patient safety (alcohol use, mental health symptoms, opioid side effects). Few experts referenced assessing or addressing OUD or overdose risk. In quantitative data, 36% of experts agreed LTOT is beneficial, 36% agreed most LTOT patients should be discontinued, and 57% agreed patients experience harm from tapering and from discontinuation.DiscussionEvidence is needed to build on and test these experts' recommendations to attempt tapering and add non‐opioid pain therapies for patients reporting harms of continued LTOT who may experience harms from tapering. Such evidence informs the development of clinical practice guidelines that provide comprehensive protocols to support the safety and functioning of this group of patients.
Pathway elucidation and heterologous reconstitution of the long‐chain alkane pentadecane biosynthesis from Pogostemon cablin
Authors: Wen Jing , Xia Wanxian , Wang Ying , Li Juan , Guo Ruihao , Zhao Yue , Fen Jing , Duan Xinyu , Wei Guo , Wang Guodong , Li Zhengguo , Xu Haiyang 
Published: November 2024

SummaryVery‐long‐chain (VLC) alkanes are major components of hydrophobic cuticular waxes that cover the aerial epidermis of land plants, serving as a waterproofing barrier to protect the plant against environmental stresses. The mechanism of VLC‐alkane biosynthesis has been extensively elucidated in plants. However, little is known about the biosynthesis of long‐chain alkanes (LC, C13 ~ C19) such as pentadecane in plants. Alkanes with different chain lengths are also major constituents of fossil fuels and thus the discovery of the alkane biosynthetic machinery in plants would provide a toolbox of enzymes for the production of renewable hydrocarbon sources and next generations of biofuels. The top leaves of Pogostemon cablin at young stage accumulate large amounts of LC‐alkane pentadecane, making this plant an excellent system for the elucidation of LC‐alkane biosynthetic machinery in plant. We show here that LC‐alkane pentadecane biosynthesis in P. cablin involves an endoplasmic reticulum (ER)‐localized complex made of PcCER1‐LIKE3 and PcCER3, homologues of Arabidopsis ECERIFERUM1 (AtCER1) and AtCER3 proteins that are involved in Arabidopsis VLC‐alkane biosynthesis. We reconstitute the biosynthesis of pentadecane in Nicotiana benthamiana by co‐expression of PcCER1‐LIKE3 and PcCER3 and further improve its production by silencing multifunctional acetyl‐CoA carboxylases involved in fatty acid elongation pathway. Taken together, we uncovered the key biosynthetic machinery of LC‐alkane pentadecane in P. cablin and demonstrated that using these newly identified enzymes to engineer this LC‐alkane for liquid biofuel production in a heterologous plant host is possible.