bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the clinical characteristics and outcomes of patients admitted to intensive care units after the Kahramanmaras (Türkiye) earthquake: a multicenter observational study
Authors: Halacli Burcin , Guven Goksel , Kaya Esat Kivanc , Yildirim Mehmet , Bulut Yuksel Nihal Deniz , Kocak Gamze , Bulut Kadir , Gulen Derful , Erdemir Sullu Begum , Kilicaslan Banu , Seven Asir Eren , Gemcioglu Emin , Simsek Meltem , Yuksel Recep Civan , Temel Sahin , Kaynar Ahmet Safa , Deveci Kamil , Alptekinoglu Mendil Nilgun , Aydin Emre , Ulger Birkan , Esmaoglu Aliye , Boyaci Dundar Nazlihan , Ortac Ersoy Ebru , Gundogan Kursat , Akinci Seda Banu , Topeli Arzu 
Published: February 2025

IntroductionThe outcomes of patients admitted to intensive care units (ICUs) after earthquakes that occurred on the 6th of February 2023 in Türkiye are unknown. Our objective was to delineate the demographic and clinical characteristics, therapeutic approaches, and ICU outcomes of earthquake victims who were hospitalized in Turkish ICUs.MethodsThis was a retrospective multicenter study of adult patients admitted to 12 ICUs across eight tertiary hospitals located in five different cities within 2 weeks after consecutive earthquakes. Clinical and laboratory data were documented at four specific time intervals: upon hospital admission and during the first, second, and third days of ICU admission. To identify independent predictors of ICU mortality, a binary logistic regression model was used for variables identified from the univariate analysis.ResultsA total of 201 patients were admitted to ICUs. The median age of the entire cohort was 36 [26–54] years. 87 patients were male (43.3%), and 114 were female (56.7%). The majority of patients (79.1%) were initially admitted to the emergency department. The median duration of being trapped under the rubble was 12 [5–31] hours. The primary reason (63.7%) for ICU admission was crush syndrome. Acute kidney injury (AKI) was identified in 61.5% of patients. Of 201 patients, 184 had information regarding ICU survival. The ICU mortality rate was 10%. A five-year increase in age, the presence of crush syndrome, and the requirement for vasopressor therapy during ICU care were independently associated with increased ICU mortality rates, while an increase of one point in the Glasgow Coma Scale (GCS) score was favorable for ICU mortality.ConclusionThis study demonstrated that crush syndrome accounted for 63.7% of the reasons for ICU admissions. The ICU mortality rate was recorded as 10%. Noteworthy independent risk factors for mortality were the presence of crush syndrome, increased age, vasopressor treatment and lower GCS score.
Analysis of central corneal thickness in systemic lupus erythematosus
Authors: Saldaña-Garrido Juan David , Cantó-Cerdán Mario , Gil-Guillén Vicente Francisco , Alfaro-Beltrá María Luisa , Sivera Francisca 
Published: February 2025

IntroductionSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with ocular involvement in up to 30% of cases. Due to its type I collagen composition, the cornea is particularly susceptible to thinning due to immune-complex deposition. A reduced central corneal thickness (CCT) is clinically relevant in glaucoma, where a thinner CCT increases glaucoma risk and in refractive surgery planning. Previous studies on CCT in SLE are limited due to methodological heterogeneity, technology use, inclusion criteria, and sample size, resulting in conflicting findings. This study aims to evaluate and compare the mean CCT values between patients with SLE and healthy controls.Materials and methodsThis cross-sectional study assessed mean CCT in 71 participants, 36 patients with SLE and 35 age- and sex-matched healthy controls, recruited from ophthalmology consultations. Participants with other risk factors for corneal thinning were excluded. A pilot study estimated a sample size of 34 participants per group. After confirming concordance using the Kappa index, one randomly selected eye per participant was included. CCT was measured using Zeiss HD Cirrus 5,000 optical coherence tomography. Correlation analysis was conducted using Spearman’s Rho coefficient, while a Loess regression was performed to visualize both linear and non-linear trends. Multivariate linear regression assessed the relationship between CCT, SLE, and other variables.ResultsPatients in the SLE group exhibited significantly thicker CCT than controls (536.44 ± 39.91 μm vs. 517.57 ± 29.62 μm, p = 0.014). Intraocular pressure (IOP) was similar between groups (14.31 ± 3.12 mmHg vs. 14.54 ± 2.36 mmHg, p = 0.898). CCT positively correlated with the length of hydroxychloroquine (HCQ) use (R: 0.357; p = 0.041), showing a trend toward an increase with prolonged usage, peaking approximately 100 months. Multivariate regression confirmed the association between SLE and higher CCT, potentially due to HCQ use.DiscussionWe established an association between CCT and the presence of SLE, with SLE patients exhibiting significantly higher CCT values, potentially due to hydroxychloroquine use. These findings have important implications for IOP assessment, glaucoma risk evaluation, and refractive surgery planning in SLE patients and those undergoing treatment with HCQ. Further prospective studies are warranted to validate these observations and explore the underlying mechanisms.
Blood compatibility evaluation of polydopamine nanoparticles
Authors: Li Sha , Yan Si-Ming , Zhang Li-Wei , Yang Xiao-Yan , Guo Zhong 
Published: February 2025

IntroductionPolydopamine nanoparticles (PDA NPs) exhibit numerous outstanding characteristics, including simple preparation, broad light absorption, drug binding ability, excellent biocompatibility and adhesive properties, making them suitable for biomedical application. However, the limited information on their hemocompatibility may hinder their progression from laboratory research to clinical application.MethodsIn this study, we investigated comprehensively the hemocompatibility of PDA NPs, assessed the effects of PDA NPs on red blood cells (RBCs) morphology and lysis, fibrinogen structure and conformation, blood coagulation, platelet activation, complement system activation, and organ toxicity.ResultsThe results indicated that PDA NPs can induce morphological changes and hemolysis in RBCs in a concentration-dependent manner. Interactions with fibrinogen suggested a disturbance in the protein’s microenvironment without significantly altering its secondary structure. This study also revealed that PDA NPs have a concentration-dependent effect on blood coagulation, platelet activation, and complement system activation. Additionally, PDA NPs showed no significant acute toxicity after intravenous injection.ConclusionThe findings offer important insights into the hemocompatibility of PDA NPs, which is essential for their safe and effective clinical use. Understanding their interactions with blood components is key to ensuring their compatibility in biomedical applications. These results are vital for guiding the development of PDA NPs for medical use, particularly in blood-contacting applications.
Exploring the role of nutritional strategies to influence physiological and cognitive mechanisms in cold weather operations in military personnel
Authors: Smid Dagmar J. , Klous Lisa , Ballak Sam B. , Catoire Milène , De Hoogh Iris M. , Hoevenaars Femke P. M. 
Published: February 2025

IntroductionAs a basis for performance optimal nutritional balance is key to keep the body functioning at homeostatic capacity. When environmental circumstances become challenging such as in a cold environment extraordinary performance is requested specifically for physiological (i.e., vascular response, diet induced thermogenesis, immune response), and cognitive mechanisms (i.e., cognitive function, psychological and cognitive wellbeing) of the human body. In this review we describe which nutritional strategies could enhance military performance in the cold by mitigation of CWIs.MethodsWe will first describe how exposure to cold affects the physiological or cognitive mechanisms itself and then we will explain how nutrition can be used to optimize these affected mechanisms. We will discuss long-term nutritional solutions preventing shortfalls and potential direct quick fixes for physiological and cognitive mechanisms.ResultsFor optimal functioning of the immune system and infection prevention, absence of micronutrient deficiencies is key and should be pursued amongst military personnel. For the effectivity of PUFA’s, Echinacea purpurea and probiotics in immune functioning, more research is needed in the CWO context. A multitude of micronutrients (i.e., nitrate, L-citrulline, L-arginine) appears to be able to enhance vasodilation, perhaps partially offsetting the detrimental effect of cold on peripheral blood circulation. Although the direct effect of diet induced thermogenesis is small in comparison to being physically active, it is of interest to investigate the effects of adding a combination of spices to the rations, such as capsaicin from red pepper, cinnamon, ginger, and menthol. Also, of interest for stimulation of thermogenesis are caffeine, and polyphenolic compounds. Caffeine and tyrosine supplementation 1 h, resp. 2 h before a cognitively demanding task during CWOs could be used to mitigate decreases in cognitive performance. Alternatives that are of interest, but need more research, include chocolate polyphenols and omega-3 fatty acids.ConclusionEven though some recommendations can be provided, it is evident that much information regarding the effectiveness and application of micronutrients in cold weather operations is still lacking. More focus should be placed on investigating (micro)nutritional solutions, practical feasibility, and implementation in operational military personnel to better understand the magnitude of the possible benefits in cold conditions.
“I feel like people would look at me like I’m dirty or like I’m a thief:” a qualitative exploration of interpersonal and intrapersonal experiences that influence recovery among adults at risk of opioid-related overdose
Authors: Szlyk Hannah S. , Jones Sara , Michener Jordan , Zhang Zhuoran , Kaiser Nina , Holtz Heidi , Frempong Melody Rachel Konadu , Lateef Husain , Hutson William , Cavazos-Rehg Patricia 
Published: February 2025

ObjectiveDue to the nature of early termination of treatment and the transient lifestyles of many people who use substances, many providers are unaware of the factors that may have contributed to their client’s engagement in treatment. Treatment providers and researchers need a better understanding of intrapersonal and interpersonal factors that impact recovery from the clients’ perspective. This study uses qualitative methods to explore these factors.MethodsEligible participants were adults who had used opioids and/or stimulants and were receiving treatment at a consenting facility. Participants completed one-month follow-up interviews after using a mobile health intervention. Transcripts were analyzed using deductive thematic analyses. Two research staff members coded the transcripts independently. The third coder identified coding discrepancies.ResultsOut of 24 participants, most were middle-aged, and the majority identified as female and as white. Half of participants (n = 12) shared that they have recovery-related worries, predominantly about finances and finding work after treatment. Twenty participants (n = 20) discussed how they currently take care of their daily needs. All participants shared proactive factors that support recovery, specifically seeking motivation from loved ones. Conversely, many participants shared how they had strained familial relationships when using substances. Twenty participants reported experiencing the theme of stigma due to their substance use, specifically by family members and providers.ConclusionMost participants are concerned about their financial future; the respective treatment facilities help to meet current basic needs. Most participants have relationships with family members and identify them as a source of support in recovery. Overall, many individuals in recovery have the tools to address interpersonal and intrapersonal challenges. Patients may still benefit from assistance planning for life post-treatment.
How is patient trust transferred from online medical platforms to offline?
Authors: Liang Lin 
Published: February 2025

IntroductionThe function of the internet medical platform has expanded from online consultation to offline diagnosis and treatment appointment, forming a complete service process combining online and offline, improving the patient's medical experience and promoting the transfer of online trust to offline. However, the existing studies pay insufficient attention to the dynamic and multi-stage characteristics of online medical trust, especially the lack of in-depth discussion on the trust transfer of patients from online to offline.MethodsThis study builds a patient trust transfer model based on relevant theories, and analyzes the influence mechanism of online reputation feedback on patients' online and offline trust combined with text mining technologies such as sentiment analysis. The research adopts the multi-dimensional analysis method, comprehensively considers the online and offline scenarios, and reveals the key drivers of trust transfer through large-scale data analysis.ResultsThe study found that doctors' online reputation feedback and interaction quality were important factors affecting patients' trust transfer. Positive online interaction and high-quality reputation feedback significantly enhanced patient trust and promoted the transfer of online trust to offline. The trust transfer process is dynamic and multi-stage, and the influencing factors of different stages are different. The study also revealed the significant difference in trust mechanism between online medicine and traditional medicine.DiscussionThis study revealed the formation and transfer mechanism of trust in online health care by building a trust transfer model, filling the gap in related research. The results provide practical guidance for the online medical platform to optimize the service process and enhance the trust of patients. In the future, we can further explore the trust transfer mechanism under different cultural backgrounds to promote the globalization of Internet medicine.
“Your behavior is not welcome here…”: forced internal displacement of sexual and gender minorities in Kenya
Authors: Igonya Emmy Kageha , Armah-Ansah Ebenezer Kwesi , Muga Winstoun , Stojanovski Kristefer 
Published: February 2025

BackgroundWhile migration studies have boomed, little is mentioned about internal displacement of queer persons. In Kenya, internal displacement of sexual and gender minorities is often overlooked and not well understood, which results in increased marginalization and vulnerabilities. The article provides an in-depth analysis of forced serial internal displacement trajectories of sexual and gender minorities, and its effect on navigating socialites and livelihoods.MethodsWe draw on qualitative data conducted between 2010 and 2023 using participant observations, in-depth interviews, case histories, and focus group discussions with LGBTQ+ persons, as well as mothers and fathers of gay men in Kenya. We used a thematic approach and principles of interpretive anthropology to organize and describe the meaning of the data as a continuous process. Broader themes were identified from the beginning of the first study, resulting in the development of a codebook framework that was reiterated over time.FindingsOur findings show that sexual and gender minorities are forced into internal migration. Factors informing are located at the individual, interpersonal, institutional, and communal levels. We identified three main themes with eight subthemes. The main themes were (1) reasons for migration, which were often related to stigma, violence and oppression, (2) patterns of migration, which primarily had rural to urban patterns and instability, and (3) kinship, networks, and social systems, which required rebuilding, and gaining “respectability” from kin.ConclusionThere can be little doubt that sexual and gender minorities face stigma and discrimination across levels of the socioecological model, and that in most cases, there has been multiplied grievances and anti- LGBTQ+ activities instigating serial forced migration. Forced serial displacement of sexual and gender minorities in Kenya requires research attention, and it might be better served if examined through the lens of “forced migration,” given the non-voluntary aspects of fleeing and displacement. Rethinking LGBTQ+ IDPs through the lens of coercion may better capture the lived experiences given the structural stigma and violence in which they live and cannot escape.
Shape and Size Variability of the Gynostemium in Epipactis helleborine (L.) Crantz (Orchidaceae)
Authors: Łobas Zbigniew , Jakubska-Busse Anna 
Published: February 2025

Epipactis helleborine (L.) Crantz is considered a challenging and phenotypically difficult species to identify due to its wide range of morphological variability. This variability is mainly observed in the perianth parts but also extends to the gynostemium structure, which has so far been considered one of the most useful diagnostic characteristics. As a result, a simple graphic illustrating the structural pattern of gynostemium morphology has appeared in 10 different forms in available European taxonomic keys, which significantly complicates the identification of this species. A total of 122 flowers of E. helleborine were collected from four natural populations in the Lower Silesia region (Poland) between 2017 and 2019 and analysed for gynostemium morphological variation. Geometric morphometric analyses, including Procrustes ANOVA, PCA, and CVA, were used to examine gynostemium shape, with statistical tests assessing variation in size and stigma inclination angle among populations, individual plants (ramets), and years of research. Statistical analysis revealed significant positive correlations between gynostemium width and height, with significant variation in size and angle of stigma inclination, primarily driven by population, while ramet and year of research had a lesser impact. Geometric morphometric analyses indicated significant population-level variation in gynostemium shape, with principal component analysis identifying the ventral view as the most informative for discriminating these differences. The first two principal components explained the major shape variation, and canonical variate analysis confirmed that this view is most important for species identification.
Investigation of the Mechanical Properties of Calcareous Sand Improved by Polyurethane Foam Adhesive Under Fixed Principal Stress Axes Shearing
Authors: Chang Dan , Xie Yongjun , Zhang Xinghua , Liu Jiankun 
Published: February 2025

The mechanical properties and envelope curve predictions of polyurethane-improved calcareous sand are significantly influenced by the magnitude and direction of principal stress. This study conducted a series of directional shearing tests with varying polyurethane contents (c = 2.5%, 5%, and 7.5%), stress Lode angles (θσ = −19.1°, 0°, 19.1°, and 30°), and major principal stress angles (α = 0°, 30°, 45°, 60°, and 90°) to investigate the strength and non-coaxial characteristics of calcareous sand improved by polyurethane foam adhesive (PFA). Key findings revealed that failure strength varied significantly with the major principal stress axis direction, initially decreasing to a minimum at α = 45° before increasing, with a 30% decrease and 25% increase observed at c = 5%. Non-coaxial characteristics between strain increment and stress directions became more pronounced, with angles varying up to 15°. Increasing polyurethane content from 2.5% to 7.5% enhanced sample strength by 20% at θσ = −19.1° and α = 60°. A generalized linear strength theory in the π-plane accurately described strength envelope variations, while a modified Lade criterion, incorporating polymer content, effectively predicted multiaxial strength characteristics with less than 10% deviation from experimental results. These contributions provide quantitative insights into failure strength and non-coaxial behavior, introduce a robust strength prediction framework, and enhance multiaxial strength prediction accuracy, advancing the understanding of polyurethane-improved calcareous sand for engineering applications.
Análise da sintomatologia das doenças murcha de Fusarium e sigatoka-negra da bananeira e proposta de diagnose com redes neurais convolucionais e aerofotogrametria
Authors: Santos Gilmar Souza , Parreira Douglas Silva 
Published: February 2025

O Brasil produziu em 2022 aproximadamente sete milhões de toneladas da banana com um valor de produção de 12 bilhões de reais. A despeito disso, a bananeira sofre com várias doenças prejudiciais à sua produção, a exemplo da Murcha de Fusarium e da Sigatoka-Negra. Neste contexto, o objetivo desta pesquisa é analisar a sintomatologia das duas doenças e propor um modelo de diagnose usando inteligência artificial com Redes Neurais Convolucionais (deep learning). As imagens das doenças para o treinamento foram obtidas em base de dados internacional. Com essas imagens, a aprendizagem supervisionada obteve uma acurácia acima de 96%. Também foi realizada duas coletas de imagens para diagnose manual e rotulagem na região rural de Cruz de Almas, Bahia e de Piedade de Caratinga, Minas Gerais. A acurácia, precisão e recall, obtidas na matriz de confusão, ficaram acima de 70%. Além disso, foi desenvolvido um método de avaliação de possíveis focos das doenças por meio de imagens aéreas por drones (aerofotogrametria). Os resultados mostraram que a Redes Neurais Convolucionais e a Aerofotogrametria, quando aplicadas juntas, são estratégias robustas e viáveis para detecção das duas doenças da bananeira.
Congelamento de sêmen de garanhões utilizando câmera criogênica com curva em aceleração
Authors: Figueiredo Leonardo de , Barreto Marcus Antônio Pessanha , Silva Arthur Andrade Helfensteller Straggiotti , Costa Karine Rangel da , Monteiro Lucas Lopes Horta , Fonseca Marcella Florencio , Shimoda Eduardo , Silva José Frederico Straggiotti 
Published: February 2025

O resultado da inseminação artificial com sêmen congelado ainda é menor quando comparado com sêmen fresco ou refrigerado. O objetivo do presente trabalho foi comparar a curva de congelamento em aceleração, com uma curva de congelamento convencional sobre os parâmetros cinéticos do sêmen equino. Foram feitas cinco coletas de sêmen de cinco garanhões da raça Mangalarga Marchador. As amostras de sêmen foram processadas e envasadas e em seguida foram submetidas ao congelamento em duas curvas de congelamento distintas. No grupo controle foi utilizada uma curva de congelamento convencional com equação linear realizada em cerca de 70 minutos. As amostras do grupo experimental foram criopreservadas utilizando uma curva de congelamento em aceleração com equação logarítmica realizada em 25 minutos e 30 segundos. Após o descongelamento as amostras foram submetidas ao teste de termorresistência (TTR) nos momentos 0, 30, 60, 90 min. Foi realizada uma análise computadorizada da cinética espermática (CASA) com auxílio do AndroVision® (Minitube). A curva de congelamento em aceleração aumentou (P < 0,05) a motilidade total e VCL em todos os tempos analisados. A motilidade progressiva, o VSL, VAP, ALH foram maiores (P < 0,05) nos tempos 0, 60, 90 minutos. Para o tempo de 30 min, não houve diferença significativa entre as duas curvas testadas. A curva de congelamento em aceleração demonstrou ser mais eficiente para a preservação da qualidade do sêmen congelado, em relação à curva convencional.