bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Menthol Attenuates Inflammation and Cardiac Remodeling After Myocardial Infarction via the Transient Receptor Potential Melastatin 8
Authors: Wang Qiang , Yang Yi , Chen Ken , Li De , Tang Bing , Peng Ke , Wang Zhen , Yang Ping , Yang Dachun , Yang Yongjian 
Published: October 2019

Abstract

BACKGROUND
Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel, mainly localized in the sensory neurons, which can be activated by menthol, a compound with a naturally cold sensation in mint. However, the effect of TRPM8 activation in inflammation and cardiac remodeling after myocardial infarction (MI) is not well defined.

METHODS
TRPM8 knockout (KO) mice (TRPM8−/−) and their wild-type littermates, aged 8 weeks, were randomly divided into sham and MI groups and were fed with chow or chow plus menthol.

RESULTS
Dietary menthol significantly attenuated MI injury, evidenced by decreased survival rates and plasma cardiac troponion I levels, reduced infarct size and cardiomyocytes, declined collagen deposition, and rescued cardiac function and hemodynamics. However, these effects of menthol disappeared when mice were lacking TRPM8. Furthermore, feeding of menthol ameliorated elevated expression of inflammatory cytokines and chemokines, and aggravated inflammation infiltration in the MI mice but not in TRPM8−/− mice. In addition, menthol treatment increased the release of calcitonin gene-related peptide (CGRP), which were absent in TRPM8−/− mice.

CONCLUSIONS
In conclusion, our results suggest that dietary menthol can protect against inflammation and cardiac remodeling after MI through activation of TRPM8.
The Hastings algorithm at fifty
Authors: Dunson D B , Johndrow J E 
Published: October 2019

SummaryIn a 1970 Biometrika paper, W. K. Hastings developed a broad class of Markov chain algorithms for sampling from probability distributions that are difficult to sample from directly. The algorithm draws a candidate value from a proposal distribution and accepts the candidate with a probability that can be computed using only the unnormalized density of the target distribution, allowing one to sample from distributions known only up to a constant of proportionality. The stationary distribution of the corresponding Markov chain is the target distribution one is attempting to sample from. The Hastings algorithm generalizes the Metropolis algorithm to allow a much broader class of proposal distributions instead of just symmetric cases. An important class of applications for the Hastings algorithm corresponds to sampling from Bayesian posterior distributions, which have densities given by a prior density multiplied by a likelihood function and divided by a normalizing constant equal to the marginal likelihood. The marginal likelihood is typically intractable, presenting a fundamental barrier to implementation in Bayesian statistics. This barrier can be overcome by Markov chain Monte Carlo sampling algorithms. Amazingly, even after 50 years, the majority of algorithms used in practice today involve the Hastings algorithm. This article provides a brief celebration of the continuing impact of this ingenious algorithm on the 50th anniversary of its publication.
Cardiac stunning during haemodialysis: the therapeutic effect of intra-dialytic exercise
Authors: McGuire Scott , Horton Elizabeth J , Renshaw Derek , Chan Klaris , Jimenez Alfonso , Maddock Helen , Krishnan Nithya , McGregor Gordon 
Published: October 2019

Abstract

Background
Cardiovascular risk is elevated in end-stage renal disease. Left ventricular (LV) dysfunction is linked to repetitive transient ischaemia occurring during haemodialysis (HD). Cardiomyocyte ischaemia results in ‘cardiac stunning’, evidenced by regional wall motion abnormalities (RWMAs). Ischaemic RWMA have been documented during HD resulting in maladaptive cardiac remodelling and increased risk of heart failure. Intra-dialytic exercise is well tolerated and can improve quality of life and functional capacity. It may also attenuate HD-induced cardiac stunning.

Methods
This exploratory study aimed to assess the effect of intra-dialytic cycle ergometry on cardiac stunning. Twenty exercise-naïve participants on maintenance HD (mean ± SD, 59 ± 11 years) underwent resting echocardiography and maximal cardiopulmonary exercise testing. Subsequently, cardiac stunning was assessed with myocardial strain-derived RWMAs at four time points during (i) standard HD and (ii) HD with 30 min of sub-maximal intra-dialytic cycle ergometry at a workload equivalent to 90% oxygen uptake at the anaerobic threshold (VO2AT). Central haemodynamics and cardiac troponin I were also assessed.

Results
Compared with HD alone, HD with intra-dialytic exercise significantly reduced RWMAs after 2.5 h of HD (total 110 ± 4, mean 7 ± 4 segments versus total 77 ± 3, mean 5 ± 3, respectively; P = 0.008). Global cardiac function, intra-dialytic haemodynamics and LV volumetric parameters were not significantly altered with exercise.

Conclusions
Intra-dialytic exercise reduced cardiac stunning. Thirty minutes of sub-maximal exercise at 90% VO2AT was sufficient to elicit acute cardio-protection. These data potentially demonstrate a novel therapeutic effect of intra-dialytic exercise.
Improved standardization of transcribed digital specimen data
Authors: Groom Quentin , Dillen Mathias , Hardy Helen , Phillips Sarah , Willemse Luc , Wu Zhengzhe 
Published: October 2019

Abstract
There are more than 1.2 billion biological specimens in the world’s museums and herbaria. These objects are particularly important forms of biological sample and observation. They underpin biological taxonomy but the data they contain have many other uses in the biological and environmental sciences. Nevertheless, from their conception they are almost entirely documented on paper, either as labels attached to the specimens or in catalogues linked with catalogue numbers. In order to make the best use of these data and to improve the findability of these specimens, these data must be transcribed digitally and made to conform to standards, so that these data are also interoperable and reusable.
Through various digitization projects, the authors have experimented with transcription by volunteers, expert technicians, scientists, commercial transcription services and automated systems. We have also been consumers of specimen data for taxonomical, biogeographical and ecological research. In this paper, we draw from our experiences to make specific recommendations to improve transcription data. The paper is split into two sections. We first address issues related to database implementation with relevance to data transcription, namely versioning, annotation, unknown and incomplete data and issues related to language. We then focus on particular data types that are relevant to biological collection specimens, namely nomenclature, dates, geography, collector numbers and uniquely identifying people. We make recommendations to standards organizations, software developers, data scientists and transcribers to improve these data with the specific aim of improving interoperability between collection datasets.
Inflammation, but Not the Underlying Disease or Its Location, Predicts Oral Iron Absorption Capacity in Patients With Inflammatory Bowel Disease
Authors: Aksan Ayşegül , Wohlrath M , Iqbal Tariq H , Dignass A , Stein J 
Published: October 2019

AbstractBackground and AimsAnaemia is common in patients with inflammatory bowel disease [IBD], its two main aetiologies being iron deficiency anaemia [IDA] and anaemia of chronic inflammation [ACI]. Impaired intestinal iron absorption due to inflammatory cytokines is thought to play a role in ACI. We undertook for the first time a controlled prospective study investigating effects of differing underlying diseases, disease locations, and types of iron deficiency or anaemia on oral iron absorption in adult IBD patients with and without inflammation.MethodsThis study was a comparative, single-centred open clinical trial in adults with IBD [n = 73] and healthy controls [n = 22]. Baseline parameters included blood count, iron status [ferritin, transferrin, transferrin saturation, soluble transferrin receptor, hepcidin, serum iron], high-sensitivity C-reactive protein [hsCRP] and interleukin-6. Iron absorption was tested using one oral, enteric-coated capsule containing 567.7 mg iron[II]-glycine-sulphate complex. Serum iron was determined 60/90/120/180/240 min after ingestion.ResultsIron absorption capacity was shown to be influenced by inflammation and anaemia or iron deficiency [ID] type but not by underlying disease type or localisation. The ACI group showed a significantly lower iron absorption capacity than all others. Whereas hsCRP levels [-0.387, p &lt; 0.001], IL-6 [-0.331, p = 0.006], ferritin [-0.531, p &lt; 0.001], and serum hepcidin [-0.353, p = 0.003] correlated negatively with serum iron change at 2 h, transferrin showed a positive correlation at the same time point [0.379, p &lt; 0.001].ConclusionsUnderlying disease type and localisation appear to have little effect on iron absorption capacity, whereas lack of response to oral iron correlates well with serum markers of inflammation. Iron absorption capacity is thus significantly reduced in the presence of inflammation.
A case report: intravalvular regurgitation during percutaneous valve-in-ring implantation due to eccentric bulging of a balloon-expandable valve in a patient with severe right heart failure
Authors: Gerçek Muhammed , Schramm René , Paluszkiewicz Lech , Rudolph Tanja Katharina 
Published: October 2019

Abstract

Background
Severely reduced right heart function and high operative risk are major challenges in the treatment of tricuspid regurgitation (TR) as both can lead to low cardiac output heart failure (LCO-Hf). Alternative methods and criteria for patient selection are actively being sought.

Case summary
We report on a 66-year-old patient with severe right heart failure (rHF) with recurrent TR after prior surgical valve repair with a 32-mm-Edwards-MC3 annuloplasty ring (AR). Surgical revision was discarded due to extreme high surgical risk. A right ventricular assist device was discussed but declined by the patient. Percutaneous edge-to-edge repair was not applicable due to massive tethering of the anterior leaflet and complete lack of coadaptation. According to the Heart team decision, percutaneous tricuspid valve-in-ring implantation was performed using a 29-mm Sapien-3 prosthesis (SP3) under moderate balloon overinflation. Despite satisfying positioning, the prosthesis showed massive intravalvular regurgitation due to immobility of the septally oriented cusp, which was most likely caused by eccentric bulging of the prosthesis in the opening region of the AR. Implantation of a second prosthesis leads to a perfectly functional result. Importantly, no major haemodynamic complications ensued.

Discussion
Although being a potential risk of tricuspid valve repair LCO-hf could not be observed in the present case. Additionally, deformation of the implanted transcatheter aortic valve replacement prosthesis resulting from the regional lack of abutment in AR should be considered as a potential complication. Hence, further careful evaluation of the feasibility of percutaneous tricuspid valve treatment, also in patients with rHF, is needed.
New Dominion constitutionalism at the twilight of the British Empire: An introduction
Authors: Malagodi Mara , McDonagh Luke , Poole Thomas 
Published: October 2019

Abstract
This introduction to the symposium on New Dominion constitutionalism sketches the legal configuration of New Dominion status and the intellectual context from which it emerged. Dominionhood originally represented a halfway house between colonial dependence and postcolonial independence, as developed in Canada, Australia, New Zealand, and South Africa. By contrast, New Dominion constitutionalism refers to the transitional constitutional form developed after World War I in Ireland (1922–1937)—the “Bridge Dominion”—and the post-World War II “New” Dominions of India (1947–1950), Pakistan (1947–1956), and Ceylon (later Sri Lanka, 1948–1972). New Dominion constitutionalism represents the first model designed to manage political transitions on a global scale. Both transitional and transnational, New Dominion constitutions served as a provisional frame of government and the juridical basis for the independent constitution. Although the notion of Dominion fell into disuse, it reemerged as the concept of Commonwealth Realm through which the majority of the remaining British colonies in Asia, Africa, and the Caribbean acquired independence.
The Dominion model of transitional constitutionalism
Authors: Malagodi Mara , McDonagh Luke , Poole Thomas 
Published: October 2019

Abstract
This symposium has explored New Dominion constitutionalism inductively and contextually, placing the phenomenon within a historically nested set of ideas and practices from the Old (Settler) Dominions, through the “Bridge Dominion” of Ireland, before giving detailed attention to the South Asian New Dominions of India, Pakistan, and Ceylon (now Sri Lanka). The articles collectively form a basis from which to analyze the legal configuration of New Dominion status and its legacy by exploring links between New Dominion constitutional framing and post-independence design and practice. Building on the case studies, the principal contention of this summative contribution is that New Dominion constitutionalism should be understood as the first constitutional model of note designed to manage political transitions on a global scale. A product of the twilight of the British Empire, New Dominion constitutionalism represents a model for decolonizing nations and an important antecedent to later post-Cold War transitions. Both transitional and transnational, New Dominion status offered an interim frame of government for political transitions, the fuzzy center of which derived from Westminster-style conventions of political constitutionalism, as well as a template establishing the legal basis for constituting the fully independent state.
A review status on alternative arrangements of power generation energy resources and reserve in India
Authors: Kumar Ravinder , Ojha Kshitij , Ahmadi Mohammad H , Raj Ritu , Aliehyaei Mehdi , Ahmadi Abolfazl , Nabipour Narjes 
Published: October 2019

Abstract
Due to the fast growth of population in India, consumption of energy is growing at a rapid rate. Today’s energy consumption and its utilization at an optimum level is a big challenge in the nation. There are various factors like a demand to mitigate global energy, availability, accessibility, cost, environmental change and storage facility of energy which are important in modern days. Majority of the population is shifting towards the city in comparison to a rural area (town, village and kasbah). According to this fact, the consumption of energy is increasing in cities. The small- and large-scale industries are located nearby the city, because of the easy availability of raw materials, better transportation services and other resources. So, the requirement of energy in a continuous manner is the prime need in these areas. In rural areas, people are using low-grade energy, and thereby there is not so much burden of energy required. It is also observed that there is a maximum loss of electricity due to transmission in India. Oil, gas and electricity are major resources to supply the energy need of the countrymen. However, the fuel situation of the nation with the shortage of fossil fuels creates pressure to drive the nuclear investment for electricity and nearly 25% contribution by 2050. The nation’s dependency on oil and gas is a critical issue, so the country is looking forward to various renewable energy resources. To accomplish this target, various government organizations are investing in solar and wind energy-related projects along with remote location pilot projects. The role of policymakers in this direction is to develop future strategies to decrease the gap between demand and supply of electricity for the growth of sustainable development. In the present work, energy production from various resources, supply, new policy implementation and import of energy is discussed in India. The study concludes that coal and petroleum product import is continuously increasing in the country for power generation and increasing the level of greenhouse gases. So, the Indian government is investing in power generation projects based on renewable energies in the country. ‘Solar Mission’ to achieve a goal of 20 000 MW solar electricity and 60 GW wind power generation by 2022 is already running in this direction.
The effects of improved performance in the U.S. dairy cattle industry on environmental impacts between 2007 and 2017
Authors: Capper Judith L , Cady Roger A 
Published: October 2019

Abstract
The U.S. dairy industry considerably reduced environmental impacts between 1944 and 2007, primarily through improved dairy cow productivity. However, although milk yield per cow has increased over the past decade, whole-system environmental impact analyses have not been conducted over this time period, during which environmental modeling science has improved considerably. The objective of this study was to compare the environmental impact of U.S. dairy cattle production in 2007–2017. A deterministic model based on population demographics, metabolism, and nutrient requirements of dairy cattle was used to estimate resource inputs, nutrient excretion, and greenhouse gas (GHG) emissions per 1.0 × 106 t (one million metric t or MMT) of energy-corrected milk (ECM) produced in 2007 and 2017. System boundaries extended from the manufacture and transport of cropping inputs to milk at the farm gate. Milk transport, processing, and retail were not included. Dairy systems were modeled using typical management practices, herd population dynamics, and production data from U.S. dairy farms. Cropping data were sourced from national databases. The resources required to produce 1.0 MMT ECM in 2017 were considerably reduced relative to those required in 2007, with 2017 production systems using 74.8% of the cattle, 82.7% of the feedstuffs, 79.2% of the land, and 69.5% of the water as compared to 2007. Waste outputs were similarly reduced, with the 2017 U.S. dairy industry producing 79.4%, 82.5%, and 85.7% of the manure, N, and P excretion, respectively. Dairy production in 2017 emitted 80.9% of the CH4 and 81.5% of the N2O per 1.0 MMT ECM compared to 2007. Enteric and manure emissions contributed the major proportion (80%) of GHG emissions per unit of milk, with lesser contributions from cropping (7.6%) and fertilizer application (5.3%). The GHG emissions per 1.0 MMT ECM produced in 2017 were 80.8% of equivalent milk production in 2007. Consequently, although total U.S. ECM production increased by 24.9% between 2007 and 2017, total GHG emissions from this milk production increased by only 1.0%. In line with previous historical analyses, the U.S. dairy industry has made remarkable productivity gains and environmental progress over time. To maintain this culture of continuous improvement, the dairy industry must build on gains made to date and demonstrate its commitment to reducing environmental impacts while improving both economic viability and social acceptability.
Practice, Discourse and Experience: The Relationship Between Design History and Architectural History
Authors: Kelly Jessica , Jamieson Claire 
Published: October 2019

Abstract
This Special Issue explores the relationship between architectural history and design history; two disciplines with close subject areas and methodological links, but which have developed distinct institutional and academic identities that often separate them. This introduction frames the articles contained in the issue—which in different ways demonstrate the compelling nature of research that straddles these disciplines—through an examination of the roots such research approaches have within the recent past of each field. Through a re-reading of key moments within the historiography of each discipline in the UK and USA since the Second World War, it is possible to understand how architectural and design history have evolved in relation to each other, and how the expansion of each into the territory of the other has emerged.
Discovery of a very young high-mass X-ray binary associated with the supernova remnant MCSNR J0513-6724 in the LMC
Authors: Maitra C , Haberl F , Filipović M D , Udalski A , Kavanagh P J , Carpano S , Maggi P , Sasaki M , Norris R P , O’Brien A , Hotan A , Lenc E , Szymański M K , Soszyński I , Poleski R , Ulaczyk K , Pietrukowicz P , Kozłowski S , Skowron J , Mróz P , Rybicki K , Iwanek P , Wrona M 
Published: October 2019

ABSTRACT
We report the discovery of a very young high-mass X-ray binary (HMXB) system associated with the supernova remnant (SNR) MCSNR J0513-6724 in the Large Magellanic Cloud (LMC), using XMM–Newton X-ray observations. The HMXB is located at the geometrical centre of extended soft X-ray emission, which we confirm as an SNR. The HMXB spectrum is consistent with an absorbed power law with spectral index ∼1.6 and a luminosity of 7 × 1033 erg s−1 (0.2–12 keV). Tentative X-ray pulsations are observed with a periodicity of 4.4 s and the OGLE I-band light curve of the optical counterpart from more than 17.5 yr reveals a period of 2.2324 ± 0.0003 d, which we interpret as the orbital period of the binary system. The X-ray spectrum of the SNR is consistent with non-equilibrium shock models as expected for young/less evolved SNRs. From the derived ionization time-scale we estimate the age of the SNR to be <6 kyr. The association of the HMXB with the SNR makes it the youngest HMXB, in the earliest evolutionary stage known to date. An HMXB as young as this can switch on as an accreting pulsar only when the spin period has reached a critical value. Under this assumption, we obtain an upper limit to the magnetic field of <5 × 1011 G. This implies several interesting possibilities including magnetic field burial, possibly by an episode of post-supernova hyper-critical accretion. Since these fields are expected to diffuse out on a time-scale of 103–104 yr, the discovery of a very young HMXB can provide us the unique opportunity to observe the evolution of the observable magnetic field for the first time in X-ray binaries.