bluuebunny/crossref_metadata_2025_split huggingface dataset:
МНОГОЛЕТНЯЯ ДИНАМИКА ПРОФИЛЯ ПОДВОДНОГО БЕРЕГОВОГО СКЛОНА (НА ПРИМЕРЕ ПЕСЧАНЫХ БЕРЕГОВ ЧЕРНОГО МОРЯ), "Геоморфология"
Authors: Корзинин Д.В. 
Published: August 2018

Анализ динамики рельефа подводного берегового склона в течение длительного периода необходим для выявления различий и общих тенденций эволюции берегов разных типов, а также для осуществления долгосрочного морфодинамического прогноза. На основе картографических данных и отдельных промеров по профилям исследуется морфодинамика берегового профиля на примере песчаных берегов трех разных типов, расположенных в северной части Черного моря. Выявленные трансформации берегового профиля, связаны с разным бюджетом прибрежно-морских осадков за исследуемый период времени, с действием штормов разной структуры и интенсивности, а также c изменением относительного уровня водоема в связи с тектоническими условиями. Признаков смещения внешней границы динамической зоны, определяемой волнением, за исследуемый временной период не обнаружено.
Nickel Chelate Derived NiS2 Decorated with Bifunctional Carbon: An Efficient Strategy to Promote Sodium Storage Performance
Authors: Zhao Ganggang , Zhang Yang , Yang Li , Jiang Yunling , Zhang Yu , Hong Wanwan , Tian Ye , Zhao Hongbo , Hu Jiugang , Zhou Liang , Hou Hongshuai , Ji Xiaobo , Mai Liqiang 
Published: August 2018

AbstractThe sodium storage performance of NiS2 suffer from low initial coulombic efficiency and poor cycling stability which are ascribed to the volume expansion and collapse of the structure during the charge/discharge transformation process. Compared with composites, encapsulating NiS2 in carbon framework is more effective in buffering for the volume expansion and enhancing the electronic conductivity of sodium‐ion batteries. In this work, NiS2 decorated with bifunctional carbon (NiS2@C@C), where nickel dimethylglyoxime and polyaniline are employed as the precursor and carbon source, respectively, are obtained. Since the introduced carbon layer suppresses the volume expansion and enhances both the electronic conductivity and charge transfer of Na+, the attained NiS2@C@C displays outstanding sodium storage performance. At a current density of 0.1 A g−1, a high reversible specific capacity of 580.8 mAh g−1 remains even after 100 cycles. The first coulombic efficiency (79.65%) and rate performance (448 mAh g−1 at 1.6 A g−1) of NiS2@C@C are also remarkable. Extraordinarily, the excogitation of NiS2 decorated with bifunctional carbon is also significant for the preparation of similar materials.
Magnetic Resonance Imaging‐Guided Drug Delivery to Breast Cancer Stem‐Like Cells
Authors: Sun Yujin , Kim Hoe Suk , Kang Sukmo , Piao Yin Ji , Jon Sangyong , Moon Woo Kyung 
Published: August 2018

AbstractThe feasibility of detecting breast cancer stem‐like cells (BCSCs) with magnetic resonance imaging using extradomain‐B of fibronectin (EDB‐FN)‐specific peptide (APTEDB)‐conjugated thermally cross‐linked superparamagnetic iron oxide nanoparticles (APTEDB‐TCL‐SPIONs) is previously demonstrated. Here, doxorubicin (Dox)‐loaded APTEDB‐TCL‐SPIONs (Dox@APTEDB‐TCL‐SPIONs) are generated and their theranostic ability in a BCSC xenograft mouse model is assessed. The Dox@APTEDB‐TCL‐SPIONs enable more efficient delivery of Dox to tumors than nontargeted Dox@TCL‐SPIONs. Much greater inhibition of BCSC tumor growth is observed after treatment with the Dox@APTEDB‐TCL‐SPIONs than with either Dox@TCL‐SPIONs or free Dox. Hypointense signals are observed in the majority of the mice in postcontrast but not precontrast T2*‐weighted MR images of tumors 7 days after treatment with Dox@APTEDB‐TCL‐SPIONs. An inverse correlation is observed between signal intensity and both EDB‐FN expression and response to chemotherapy. The data indicate Dox@APTEDB‐TCL‐SPIONs can detect BCSCs within tumors by targeting EDB‐FN‐expressing cells. These nanoparticles thus have theranostic potential in breast cancer.
Chemically Reactive Polyurethane–Carbon Nanotube Fiber with Aerogel‐Microsphere‐Thin‐Film Selective Filter
Authors: Jeong Sang‐Mi , Kang Youngsoo , Lim Taekyung , Ju Sanghyun 
Published: August 2018

AbstractRecently, as the frequency of use of volatile organic compounds (VOCs) in everyday life has increased, there is an increasing interest in chemical sensors that can easily confirm the degree of exposure to VOCs in the surrounding environment in real time. Among the various chemical sensors, the fiber‐type chemical sensor is flexible and lightweight and can be applied to various wearable electronics, such as clothing and ornaments. In this study, a chemically reactive polyurethane–carbon nanotube (PU–CNT) composite fiber coated with an aerogel‐microsphere‐thin‐film (AMTF) is fabricated by using the PU as an insulating body material and CNTs as a 1D conductive material, which provide excellent elasticity and flexibility. The AMTF, which can block liquid‐phase VOCs/water and allow only vapor‐state VOCs to permeate, is introduced to the surface of the sensing channel of the fiber‐type chemical sensor. The PU–CNT composite fiber with the AFMT is able to measure the concentration of various VOCs in water. Thus, it solves the problem that water in contrast to the VOCs to be sensed – cannot be reliably changed by absorption and expansion into the polymer chain when the fiber‐type chemical sensor based on polymer conductive composite materials comes into contact with liquid.
Extending the Spectral Responsivity of MoS2 Phototransistors by Incorporating Up‐Conversion Microcrystals
Authors: Zhang Youwei , Wang Jiao , Wang Bing , Shao Jinhai , Deng Jianan , Cong Chunxiao , Hu Laigui , Tian Pengfei , Liu Ran , Zhang Shi‐Li , Qiu Zhi‐Jun 
Published: August 2018

AbstractLayered 2D semiconductors are characterized by unique photoelectric properties and, therefore, constitute a new class of basic building block for next‐generation optoelectronics. However, their wide bandgaps limit the spectral responsivity to a narrow range. Here, a facile approach is demonstrated by integrating β‐NaYF4:Yb3+, Er3+ up‐conversion microcrystals (UCMCs) with monolayer‐MoS2 phototransistors to break this bandgap‐imposed barrier and to drastically extend the responsivity range. In essence, the UCMCs up‐convert a near‐infrared excitation at 980 nm to visible light of photons with energy matching the large bandgap (i.e., 1.8 eV) of monolayer‐MoS2, thereby activating the phototransistor with remarkable photocurrent and minimum interference. This approach leads to preservation of the excellent electrical merits of monolayer‐MoS2 and simultaneous retention of its low dark current and high photoresponsivity to the above‐bandgap lights. Significantly, an enhancement by over 1000 times is achieved for both responsivity and specific detectivity at 980 nm excitation. Moreover, the rate of response is kept identical to that when the MoS2 phototransistor is excited by a visible light. Therefore, integrating with UCMCs can enable the emerging 2D semiconductors of wide bandgap to respond to infrared excitations with high efficacy and without sacrificing their performance in the visible region.
Rhodium‐Catalyzed Annulations of 1,3‐Dienes and Salicylaldehydes/2‐Hydroxybenzyl Alcohols Promoted by 2‐Ethylacrolein
Authors: Li Hong‐Shuang , Xiong Yang , Zhang Guozhu 
Published: August 2018

AbstractA rhodium‐catalyzed 2‐ethylacrolein‐promoted protocol enables the annulation reactions of 1,3‐dienes with either salicylaldehydes or 2‐hydroxybenzyl alcohols leading to 2‐alkylchroman‐4‐ones with high regioselectivity. This research highlights the use of 2‐ethylacrolein which probably serves as a tool of bidentate coordination to rhodium intermediates. Mechanistic studies reveal that the transformation proceeds through the 1,4‐hydroacylation pathway to access unsaturated linear ketones with subsequent oxo‐Michael addition.magnified image
Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer
Authors: Tian Ye , Guo Ranran , Yang Wuli 
Published: August 2018

AbstractRecently, photothermal therapy (PTT) has demonstrated excellent results in the treatment of preclinical cancer models and thus attracted intensive interests from the research fields of material science, biochemistry, oncology, and pharmacy. Also, its combination with other cancer therapies shows great promise for clinical application: PTT is able to make up for the drawbacks of others and improve the prognosis through various synergistic effects. In these combination therapies, design of nanoscale multifunctional therapeutics is key to achieve enhanced or even synergistic therapeutic effect. Herein, the recent progress is summarized in the development of strategies involving combination of PTT with other cancer therapies, conventional or emerging, with increased efficacy. The highlight lies in integrating various functional units to form multifunctional nanomaterials that play the role of photothermal agents as well as other therapeutics in a combination therapy and the design of an effective targeted delivery system for them. Smart combination of therapies will undoubtedly improve the therapeutic efficacy and make a contribution to the advancement in fighting cancer.
Variable Clinical Manifestations of Xia‐Gibbs syndrome: Findings of Consecutively Identified Cases at a Single Children's Hospital
Authors: Ritter Alyssa L. , McDougall Carey , Skraban Cara , Medne Livija , Bedoukian Emma C. , Asher Stephanie B. , Balciuniene Jorune , Campbell Colleen D. , Baker Samuel W. , Denenberg Elizabeth H. , Mazzola Sarah , Fiordaliso Sarah K. , Krantz Ian D. , Kaplan Paige , Ierardi‐Curto Lynne , Santani Avni B. , Zackai Elaine H. , Izumi Kosuke 
Published: August 2018

AbstractXia‐Gibbs syndrome (XGS) is a recently described neurodevelopmental disorder due to heterozygous loss‐of‐function AHDC1 mutations. XGS is characterized by global developmental delay, intellectual disability, hypotonia, and sleep abnormalities. Here we report the clinical phenotype of five of six individuals with XGS identified prospectively at the Children's Hospital of Philadelphia, a tertiary children's hospital in the USA. Although all five patients demonstrated common clinical features characterized by developmental delay and characteristic facial features, each of our patients showed unique clinical manifestations. Patient one had craniosynostosis; patient two had sensorineural hearing loss and bicuspid aortic valve; patient three had cutis aplasia; patient four had soft, loose skin; and patient five had a lipoma. Differential diagnoses considered for each patient were quite broad, and included craniosynostosis syndromes, connective tissue disorders, and mitochondrial disorders. Exome sequencing identified a heterozygous, de novo AHDC1 loss‐of‐function mutation in four of five patients; the remaining patient has a 357kb interstitial deletion of 1p36.11p35.3 including AHDC1. Although it remains unknown whether these unique clinical manifestations are rare symptoms of XGS, our findings indicate that the diagnosis of XGS should be considered even in individuals with additional non‐neurological symptoms, as the clinical spectrum of XGS may involve such non‐neurological manifestations. Adding to the growing literature on XGS, continued cohort studies are warranted in order to both characterize the clinical spectrum of XGS as well as determine standard of care for patients with this diagnosis.
A comprehensive analysis of SNCA‐related genetic risk in sporadic parkinson disease
Authors: Pihlstrøm Lasse , Blauwendraat Cornelis , Cappelletti Chiara , Berge‐Seidl Victoria , Langmyhr Margrete , Henriksen Sandra Pilar , van de Berg Wilma D. J. , Gibbs J. Raphael , Cookson Mark R. ,   the International Parkinson Disease Genomics Consortium,   the North American Brain Expression Consortium, Singleton Andrew B. , Nalls Mike A. , Toft Mathias 
Published: August 2018

ObjectiveThe goal of this study was to refine our understanding of disease risk attributable to common genetic variation in SNCA, a major locus in Parkinson disease, with potential implications for clinical trials targeting α‐synuclein. We aimed to dissect the multiple independent association signals, stratify individuals by SNCA‐specific risk profiles, and explore expression quantitative trait loci.MethodsWe analyzed participant‐level data from 12,503 patients and 12,502 controls, optimizing a risk model and assessing SNCA‐specific risk scores and haplotypes as predictors of individual risk. We also explored hypotheses about functional mechanisms and correlated risk variants to gene expression in human brain and protein levels in cerebrospinal fluid.ResultsWe report and replicate a novel, third independent association signal at genome‐wide significance level downstream of SNCA (rs2870004, p = 3.0*10−8, odds ratio [OR] = 0.88, 95% confidence interval [CI] = 0.84–0.92). SNCA risk score stratification showed a 2‐fold difference in disease susceptibility between top and bottom quintiles (OR = 1.99, 95% CI = 1.78–2.23). Contrary to previous reports, we provide evidence supporting top variant rs356182 as functional in itself and associated with a specific SNCA 5′ untranslated region transcript isoform in frontal cortex.InterpretationThe SNCA locus harbors a minimum of 3 independent association signals for Parkinson disease. We demonstrate a fine‐grained stratification of α‐synuclein–related genetic burden in individual patients of potential future clinical relevance. Further efforts to pinpoint the functional mechanisms are warranted, including studies of the likely causal top variant rs356182 and its role in regulating levels of specific SNCA mRNA transcript variants. Ann Neurol 2018;83:117–129
Metal‐Free and Redox‐Neutral Conversion of Organotrifluoroborates into Radicals Enabled by Visible Light
Authors: Liu Wenbo , Liu Peng , Lv Leiyang , Li Chao‐Jun 
Published: August 2018

AbstractConverting organoboron compounds into the corresponding radicals has broad synthetic applications in organic chemistry. To achieve these transformations, various strong oxidants such as Mn(OAc)3, AgNO3/K2S2O8, and Cu(OAc)2, in stoichiometric amounts are required, proceeding by a single‐electron transfer mechanism. Established herein is a distinct strategy for generating both aryl and alkyl radicals from organotrifluoroborates through an SH2 process. This strategy is enabled by using water as the solvent, visible light as the energy input, and diacetyl as the promoter in the absence of any metal catalyst or redox reagent, thereby eliminating metal waste. To demonstrate its synthetic utility, an efficient acetylation to prepare valuable aryl (alkyl) methyl ketones is described and applications to construct C−C, C−I, C−Br, and C−S bonds are also feasible. Experimental evidence suggests that triplet diacetyl serves as the key intermediate in this process.
Adaptive Structured Pickering Emulsions and Porous Materials Based on Cellulose Nanocrystal Surfactants
Authors: Li Yanan , Liu Xubo , Zhang Zhen , Zhao Shaojie , Tian Guifang , Zheng Jinkai , Wang Dong , Shi Shaowei , Russell Thomas P. 
Published: August 2018

AbstractTaking advantage of the formation and assembly of cellulose nanocrystal surfactants (CNCSs) at the water–oil interface, where polar cellulose nanocrystals (CNCs) and end‐functionalized polymer chains interact, the preparation and stability of emulsions prepared with CNCSs were investigated. The packing density of CNCSs at the interface can be adjusted by tuning parameters such as pH, ionic strength, and concentration/molecular weight of the end‐functionalized polymer ligands. Stable non‐spherical emulsions are obtained during homogenization, as a result of the interfacial jamming of CNCSs, with pH‐triggered reconfigurability. Porous materials are prepared by freeze‐drying creamed, CNCS‐stabilized emulsions. The cells of the porous materials have a controlled pore size and shape that are commensurate with the droplets in the emulsion and are responsive to pH. The behavior of the adaptive, reconfigurable supracolloidal system is coupled to its internal and surrounding environment.
Long‐Term Clinical Outcomes in a Cohort of Adults With Childhood‐Onset Systemic Lupus Erythematosus
Authors: Groot N. , Shaikhani D. , Teng Y. K. O. , de Leeuw K. , Bijl M. , Dolhain R. J. E. M. , Zirkzee E. , Fritsch‐Stork R. , Bultink I. E. M. , Kamphuis S. 
Published: August 2018

ObjectiveChildhood‐onset systemic lupus erythematosus (SLE) is a severe, lifelong, multisystem autoimmune disease. Long‐term outcome data are limited. This study was undertaken to identify clinical characteristics and health‐related quality of life (HRQoL) of adults with childhood‐onset SLE.MethodsPatients participated in a single study visit comprising a structured history and physical examination. Disease activity (scored using the SLE Disease Activity Index 2000 [SLEDAI‐2K]), damage (scored using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and HRQoL (scored using the Short Form 36 Health Survey) were assessed. Medical records were reviewed.ResultsIn total, 111 childhood‐onset SLE patients were included; the median disease duration was 20 years, 91% of patients were female, and 72% were white. Disease activity was low (median SLEDAI‐2K score 4), and 71% of patients received prednisone, hydroxychloroquine (HCQ), and/or other disease‐modifying antirheumatic drugs. The vast majority of new childhood‐onset SLE–related manifestations developed within 2 years of diagnosis. Damage such as myocardial infarctions began occurring after 5 years. Most patients (62%) experienced damage, predominantly in the musculoskeletal, neuropsychiatric, and renal systems. Cerebrovascular accidents, renal transplants, replacement arthroplasties, and myocardial infarctions typically occurred at a young age (median age 20 years, 24 years, 34 years, and 39 years, respectively). Multivariate logistic regression analysis showed that damage accrual was associated with disease duration (odds ratio [OR] 1.15, P < 0.001), antiphospholipid antibody positivity (OR 3.56, P = 0.026), and hypertension (OR 3.21, P = 0.043). Current HCQ monotherapy was associated with an SDI score of 0 (OR 0.16, P = 0.009). In this cohort, HRQoL was impaired compared to the overall Dutch population. The presence of damage reduced HRQoL scores in 1 domain. High disease activity (SLEDAI‐2K score ≥8) and changes in physical appearance strongly reduced HRQoL scores (in 4 of 8 domains and 7 of 8 domains, respectively).ConclusionThe majority of adults with childhood‐onset SLE in this large cohort developed significant damage at a young age and had impaired HRQoL without achieving drug‐free remission, illustrating the substantial impact of childhood‐onset SLE on future life.
Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies
Authors: Ge Changrong , Xu Bingze , Liang Bibo , Lönnblom Erik , Lundström Susanna L. , Zubarev Roman A. , Ayoglu Burcu , Nilsson Peter , Skogh Thomas , Kastbom Alf , Malmström Vivianne , Klareskog Lars , Toes René E. M. , Rispens Theo , Dobritzsch Doreen , Holmdahl Rikard 
Published: August 2018

ObjectiveAnti–citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross‐reactivity of ACPAs from patients with RA.MethodsAntibodies isolated from RA patients were expressed as monoclonal chimeric antibodies with mouse Fc. These antibodies were characterized for glycosylation using mass spectrometry, and their cross‐reactivity was assessed using Biacore and Luminex immunoassays. The crystal structures of the antigen‐binding fragment (Fab) of the monoclonal ACPA E4 in complex with 3 different citrullinated peptides were determined using x‐ray crystallography. The prevalence of autoantibodies reactive against 3 of the citrullinated peptides that also interacted with E4 was investigated by Luminex immunoassay in 2 Swedish cohorts of RA patients.ResultsAnalysis of the crystal structures of a monoclonal ACPA from human RA serum in complex with citrullinated peptides revealed key residues of several complementarity‐determining regions that recognized the citrulline as well as the neighboring peptide backbone, but with limited contact with the side chains of the peptides. The same citrullinated peptides were recognized by high titers of serum autoantibodies in 2 large cohorts of RA patients.ConclusionThese data show, for the first time, how ACPAs derived from human RA serum recognize citrulline. The specific citrulline recognition and backbone‐mediated interactions provide a structural explanation for the promiscuous recognition of citrullinated peptides by RA‐specific ACPAs.
Superbenzene–Porphyrin Gas‐Phase Architectures Derived from Intermolecular Dispersion Interactions
Authors: Lungerich Dominik , Hitzenberger Jakob F. , Hampel Frank , Drewello Thomas , Jux Norbert 
Published: August 2018

AbstractA systematic series of superbenzene–porphyrin conjugates was synthesized and characterized. All conjugates show a high degree of cluster formation that correlates to the amount of tert‐butylated hexa‐peri‐hexabenzocoronenes (tBuHBCs) attached to the porphyrin's periphery. Determined by mass spectrometry and X‐ray diffraction, van der Waals (vdW) interactions like London dispersions (LD), stemming from solubilizing tert‐butyl groups, were identified to be the major reason for the cluster formation. Cluster sizes comprised of more than twenty molecules with masses up to 70 000 Da were observed, which are rare examples of large architectures based on synthetic functional molecules, assembled by dispersion interactions. Novel strategies towards the design of solution processable functional materials, capable of dynamic transformations based on non‐covalent synthesis can be envisioned.
Cold Sintering of a Covalently Bonded MoS2/Graphite Composite as a High Capacity Li–Ion Electrode
Authors: Nayir Selda , Waryoba Daudi R. , Rajagopalan Ramakrishnan , Arslan Cüneyt , Randall Clive A. 
Published: August 2018

AbstractABSTRACT. A cold sintering approach is demonstrated to fabricate highly dense electrochemically active MoS2/graphite (MG) composites with 88% relative density at an extremely low processing temperature of 140 °C. The process provides a pathway to sinter covalently bonded materials effectively to produce either dense or near dense pellets and/or thick films. Composites that include up to 20 wt% graphite, as well as a Li‐ionic solid electrolyte (lithium aluminum germanium phosphate) could be easily integrated and densified using this method. Cold sintering also offers an elegant approach to achieve very low interfacial electrode resistances (∼42 Ω cm2) through the densification process. The specific capacity of the fabricated composite electrode was ∼ 950 mAh/g at 0.1 A/g and also displayed good capacity retention at higher current densities.