bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐Infrared Tandem Organic Photodiodes for Future Application in Artificial Retinal Implants
Authors: Simone Giulio , Di Carlo Rasi Dario , de Vries Xander , Heintges Gaël H. L. , Meskers Stefan C. J. , Janssen René A. J. , Gelinck Gerwin H. 
Published: October 2018

AbstractPhotovoltaic retinal prostheses show great potential to restore sight in patients suffering from degenerative eye diseases by electrical stimulation of the surviving neurons in the retinal network. Herein, organic photodiodes (OPDs) sensitive to near‐infrared (NIR) light are evaluated as photovoltaic pixels for future application in retinal prostheses. Single‐junction and tandem OPDs are compared. In the latter, two nominally identical single‐junction cells are processed on top of each other, effectively doubling the open‐circuit voltage (V
OC). Both single‐junction and tandem OPD micropixels can deliver the required charge to stimulate neurons under pulsed NIR light at physiologically safe intensities when connected to stimulating microelectrodes in a physiological saline solution. However, only tandem OPD pixels can cover the entire charge per pulse neural stimulation window due to their higher V
OC (≈1.4 V). This demonstrates the viability of high‐resolution retinal prostheses based on flexible OPD arrays.
Rational Construction of Highly Tunable Donor–Acceptor Materials Based on a Crystalline Host–Guest Platform
Authors: Zhang Da‐Shuai , Gao Qiang , Chang Ze , Liu Xiao‐Ting , Zhao Bei , Xuan Zhi‐Hong , Hu Tong‐Liang , Zhang Ying‐Hui , Zhu Jian , Bu Xian‐He 
Published: October 2018

AbstractOrganic donor–acceptor systems have attracted much attention due to their various potential applications. However, the rational construction and modulation of highly ordered donor–acceptor systems could be a challenge due to the complicated self‐assembly process of donor and acceptor species. Considering the well‐defined arrangement of species at the molecule level, a crystalline host–guest system could be an ideal platform for the rational construction of donor–acceptor systems. Herein, it is shown how the rational construction of highly tunable donor–acceptor materials can be achieved based on a crystalline host–guest platform. Within the well‐established metal–organic framework NKU‐111 as the crystalline host enabled by the relatively stable coordination‐directed assembly, the introduction and arrangement of guest molecules in the crystals allow the rational construction of the NKU‐111⊃guest donor–acceptor system. The donor–acceptor interaction in the systems can be readily modulated with different guest molecules, which can be justified by the well‐demonstrated guest‐dependent characteristics. Accordingly, the NKU‐111⊃guest reveals highly tunable donor–acceptor properties such as charge‐transfer‐based emissions and electrical conductivity. This work indicates the potential of crystalline host–guest systems as an ideal platform for systematic investigations of donor–acceptor materials.
Plasma‐Assisted Growth of β‐MnO2 Nanosystems as Gas Sensors for Safety and Food Industry Applications
Authors: Barreca Davide , Gasparotto Alberto , Gri Filippo , Comini Elisabetta , Maccato Chiara 
Published: October 2018

AbstractThe development of efficient sensors for security field and food quality control applications has gained an ever‐increasing attention for various end‐uses. In this context, this work reports on the preparation of β‐MnO2 nanosystems by plasma enhanced‐chemical vapor deposition (PE‐CVD), using a fluorinated Mn(II) diamine‐diketonate as single‐source precursor for both Mn and F. Modulations of oxygen partial pressure enable to tailor not only the morphology and oxygen vacancy content, but also fluorine doping level of the resulting systems. For the first time, the gas sensing performances of PE‐CVD β‐MnO2 nanomaterials are tested in the detection of acetonitrile, a poisonous chemical warfare agent (CWA) simulant, and ethylene, an important marker of fruit ripening. The obtained results demonstrate that the fabricated sensors can efficiently detect these analytes, with the best responses at moderate temperatures (≤200 °C), enhanced by a higher oxygen vacancy content and fluorine concentration. These features, coupled with the good selectivity and response times, candidate the developed systems as amenable platforms for practical applications.
Superior Performance of Silver Bismuth Iodide Photovoltaics Fabricated via Dynamic Hot‐Casting Method under Ambient Conditions
Authors: Ghosh Biplab , Wu Bo , Guo Xintong , Harikesh Padinhare Cholakkal , John Rohit Abraham , Baikie Tom , Arramel  , Wee Andrew T. S. , Guet Claude , Sum Tze Chien , Mhaisalkar Subodh , Mathews Nripan 
Published: October 2018

AbstractBismuth‐based ternary halides have recently gained a lot of attention as lead‐free perovskite materials. However, photovoltaic performances of these devices remain poor, mostly due to their low‐dimensional crystal structure and large bandgap. Here, a dynamic hot casting technique to fabricate silver bismuth iodide‐based perovskite solar cells under an ambient atmosphere with power conversion efficiencies above 2.5% is demonstrated. Silver bismuth iodides are 3D analogs of complex ternary bismuth halides with a suitable bandgap for a single junction solar cell. As far as it is known, these results represent the highest efficiency for solution processed air‐stable lead‐free perovskite solar cells. The enhanced solar cell performance via this dynamic hot casting technique can be attributed to long carrier lifetimes, micrometer‐sized crystalline grains, and pinhole free thin‐film formation with uniform morphology. This work provides a new direction for fabrication of solution‐processed lead‐free perovskite solar cells with a rapid fabrication strategy irrespective of the processing environment.
Simultaneously Inhibiting Lithium Dendrites Growth and Polysulfides Shuttle by a Flexible MOF‐Based Membrane in Li–S Batteries
Authors: He Yibo , Chang Zhi , Wu Shichao , Qiao Yu , Bai Songyan , Jiang Kezhu , He Ping , Zhou Haoshen 
Published: October 2018

AbstractLithium–sulfur (Li–S) batteries are considered a promising candidate for next‐generation energy storage devices due to their ultrahigh theoretical energy density (≈2600 Wh kg−1). However, the uncontrolled growth of Li dendrites and the adverse effect of polysulfide shuttling seriously hinder their practical applications. Herein, a metal organic framework based membrane (MOF@PVDF‐HFP) with good flexibility is designed and fabricated by a facial vacuum filtration strategy. The highly uniform pore sizes of MOF particles facilitate homogenous Li‐ion fluxes, fundamentally inhibiting the growth of Li dendrites and resulting in stable Li plating/striping even at a quite high current density (10 mA cm−2). In addition, owing to the narrow pore size window of MOF nanoparticles, the MOF@PVDF‐HFP membrane serves as an effective barrier for suppressing the polysulfide shuttle, realizing an ultralong cycle life Li–S coin cell with an ultralow capacity fading upon 2000 cycles (0.015% per cycle). Moreover, high specific capacity (1269 mA h g−1) and excellent capacity retention (936 mA h g−1 after 200 cycles) of a flexible Li–S pouch cell with a high sulfur loading (5.8 mg cm−2) demonstrate the potential of MOF@PVDF‐HFP membranes for the development of practical energy storage devices.
Total Synthesis of an Atropisomer of the Schisandra Triterpenoid Schiglautone A
Authors: Ma Binjie , Zhao Yifan , He Chi , Ding Hanfeng 
Published: October 2018

AbstractA diastereoselective approach for the total synthesis of an unusual atropisomer of the Schisandra triterpenoid (±)‐schiglautone A is described. The efficient synthetic strategy features three key transformations: 1) two sequential titanium(III)‐catalyzed radical cyclization/homologation reactions to construct the trans‐fused [6,7] bicycle as well as install the quaternary carbons at C10 and C14 with the desired stereochemistry; 2) a Claisen rearrangement followed by a ring‐closing metathesis to forge the strained nine‐membered ring; and 3) a substrate‐controlled Michael addition to enable the introduction of the C17 side‐chain with good diastereoselectivity.
Selective CO2 Splitting by Doubly Reduced Aryl Boranes to Give CO and [CO3]2−
Authors: von Grotthuss Esther , Prey Sven E. , Bolte Michael , Lerner Hans‐Wolfram , Wagner Matthias 
Published: October 2018

AbstractAlkali metal salts M2[1] (M=Li, Na) of doubly reduced 9,10‐dimethyl‐9,10‐dihydro‐9,10‐diboraanthracene (1) instantaneously add the C=O bond of CO2 across their boron centers to furnish formal [4+2]‐cycloadducts M2[2]. If only 1 equiv of CO2 is supplied, these products are stable. In the presence of excess CO2, however, C−O bond cleavage occurs and an O2− equivalent is transferred to CO2 to furnish CO and [CO3]2−. With M=Li, Li2CO3 precipitates and the neutral 1 is liberated such that it can be reduced again to establish a catalytic cycle. With M=Na, [CO3]2− remains coordinated to both boron atoms in a bridging mode (Na2[4]). A mechanistic scenario is proposed, based on isolated intermediates and model reactions.
High recovery of intracellular recombinant HBsAg from Pichia pastoris via continuous pulsed laser cell disruption system optimized by response surface methodology
Authors: Gazor Maryam , Ashraf Talesh Seyed Siamak , Hosseini Seyed Nezamedin , Javidanbardan Amin , Khatami Maryam 
Published: October 2018

AbstractIn our previous study, we demonstrated that continuous power laser could be a clean, rapid, and convenient alternative to the other conventional disruption techniques for the release of recombinant hepatitis B surface antigen (rHBsAg) from Pichia pastoris. In the current work, we examined the effect of pulsed laser in the continuous laboratory‐scale process on cell disruption. Design‐of‐experiments (DOE) methodology was used for optimization of cell disruption process to obtain the highest protein concentration in the disruption buffer. Our investigations for the pulsed laser at wavelength of 1,064 nm demonstrated that for disrupting P. pastoris cell and releasing rHBsAg, the laser power was the most influential factor, and laser pulse duration and cycle number were in the second and third places. According to the results, the effect of laser power and pulse duration (time) had a direct relationship with protein concentration. For the number of cycles, however, increasing the value from the lowest point at first led to the enhancement and then reduction of protein concentration. The maximum cell disruption and rHBsAg release were recorded for the laser system in the energy input of 284 mW and the pulse duration of 100 mSec after four complete rounds of circulation.
The influence of physico‐chemical parameters, substrate concentration, and species variations on the biochemical methane production rates of ten tropical/subtropical grasses
Authors: Holder Nikolai , Persaud Amiesha , Mota‐Meira Marilaine , Born Jens , Sutrina Sarah L. 
Published: October 2018

AbstractThere are several problems faced by small island developing states (SIDS), especially when it comes to waste management and energy production. There is little land space available for dumping and fuel has to be imported in order to meet energy demands. These problems can be mitigated by using grass cuttings from landscaping, which are often dumped, to produced biogas, which can be used as a fuel. In this study the rates of methane production of 10 different tropical and subtropical species of grasses were determined. Based on the results for 20 g/kg samples, the specific rates of gas production ranged from 2.40 ± 0.21 NmL/gFM/day (Zoysia matrella) to 6.52 ± 0.36 NmL/gFM/day (lemon grass). It was also observed that organic dry matter (oDM) loads did not correlate with methane production, suggesting that the oDM content is not necessarily an accurate indicator of a substrate's methane potential, and highlighting areas for further study. The results in this paper provide a database on the rates of methane production of grasses which are common to the tropical and subtropical regions and can be found in several SIDS. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd.
Integrated analysis of long noncoding RNA interactions reveals the potential role in progression of human papillary thyroid cancer
Authors: You Xin , Zhao Yixin , Sui Jing , Shi Xianbiao , Sun Yulu , Xu Jiahan , Liang Geyu , Xu Qingxiang , Yao Yongzhong 
Published: October 2018

AbstractRecent scientific evidence has suggested that long noncoding RNAs (lncRNAs) play an important part in tumorigenesis as an important member of competing endogenous RNAs (ceRNAs). Hundreds of RNA sequence data and relevant clinic information are freely accessible in The Cancer Genome Atlas (TCGA) datasets. However, the role of cancer‐related lncRNAs in papillary thyroid cancer (PTC) is not fully understood yet. In this study, we identified 461 RNA sequencing data from TCGA. Subsequently, 45 lncRNAs, 21 miRNAs, and 78 mRNAs were chosen to construct a ceRNA network of PTC. Then, we analyzed the correlation between these 45 PTC‐specific lncRNAs and clinic features and patient outcome. Thirty‐seven of these lncRNAs were found to be closely related to age, race, gender, lymph node metastasis, TNM staging system, and patient outcome. Additionally, three of them were linked to PTC patient overall survival. Eventually, we selected eight lncRNAs randomly and performed quantificational real‐time polymerase chain reaction (qRT‐PCR) in 28 newly diagnosed patients with PTC to verify the reliability of the above results. The results of qRT‐PCR are totally in agreement with the bioinformatics analysis. Additionally, it was found that HAND2‐AS1 was negatively related to tumor size (P < 0.05). The results were consistent with the bioinformatics analysis in TCGA. Taken together, we identified the differentially expressed lncRNAs and constructed a PTC ceRNA network. The study provides a new perspective and supplement for our understanding of lncRNAs in PTC development and reveals potential diagnostic and prognostic markers in PTC.
A prospective analysis of symptom burden for patients with chronic myeloid leukemia in chronic phase treated with frontline second‐ and third‐generation tyrosine kinase inhibitors
Authors: Zulbaran‐Rojas Alejandro , Lin Huei‐Kan , Shi Qiuling , Williams Loretta A. , George Binsah , Garcia‐Manero Guillermo , Jabbour Elias , O’Brien Susan , Ravandi Farhad , Wierda William , Estrov Zeev , Borthakur Gautam , Kadia Tapan , Cleeland Charles , Cortes Jorge E. , Kantarjian Hagop 
Published: October 2018

AbstractBackgroundTreatment with tyrosine kinase inhibitors (TKIs) for patients with chronic myeloid leukemia (CML) is effective but needs to continue for several years, possibly indefinitely. Although generally safe, TKI may have hitherto poorly recognized effects in the quality of life (QoL) of such patients.MethodsWe prospectively measured the symptom burden of patients with chronic phase CML enrolled on frontline TKI trials with dasatinib, nilotinib, or ponatinib. A total of 219 patients were enrolled and filled out the MD Anderson Symptom Inventory (MDASI)‐CML questionnaire before the start of therapy and during follow‐up at defined time points of 3, 6, 9, 12, 18, and 24 months.ResultsThe median age was 50 years. Longitudinal analysis showed relatively stable symptom severity scores over time. Fatigue was the most common symptom in all three cohorts, both prior to the start of therapy and during therapy, including after achievement of deep molecular remission. Work was the most affected component of daily living. Overall patients tolerated therapy well with improvement of their symptoms from baseline, with few dose reductions related to toxicity or symptomatology. Although 31% of the patients who completed MDASI‐CML achieved complete molecular remission by 24 months of treatment, nearly 90% experienced persistent mild symptoms.ConclusionSide effects related to TKIs may impact the quality of life in patients with CML‐CP. Further studies should investigate factors (comorbidities, concomitant medications, dose and schedule, etc) associated with these symptoms and interventions that may improve the patients’ QoL, including treatment discontinuation when safely feasible.
Fc‐gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer
Authors: Shepshelovich Daniel , Townsend Amanda R. , Espin‐Garcia Osvaldo , Latifovic Lidija , O’Callaghan Chris J. , Jonker Derek J. , Tu Dongsheng , Chen Eric , Morgen Eric , Price Timothy J. , Shapiro Jeremy , Siu Lillian L. , Kubo Michiaki , Dobrovic Alexander , Ratain Mark J. , Xu Wei , Mushiroda Taisei , Liu Geoffrey 
Published: October 2018

AbstractBackgroundTwo germ line Fc‐γ receptor (FCGR) polymorphisms, rs1801274 [FCGR2A; His(H)131Arg(R)] and rs396991 [FCGR3A; Phe(F)158Val(V)], produce altered proteins through amino acid substitutions. We previously reported that the FCGR2A H/H genotype was associated with longer overall survival (OS) in cetuximab‐treated chemotherapy‐refractory patients with metastatic colorectal cancer. Here, we aimed to replicate and extend this finding in the Canadian Clinical Trials Group CO.20 trial.MethodsAfter germ line DNA genotyping, polymorphic relationships with survival were assessed using log‐rank tests and hazard ratios (HR) from Cox proportional hazard models, adjusting for known prognostic factors. The dominant genetic inheritance model was used for the main analysis.ResultsOf 592 wild‐type KRAS patients treated with cetuximab, those with the FCGR2A H/H genotype (n = 165, 28%) had improved OS (HR: 0.66, P < 0.001; median absolute benefit, 1.3 months) compared to those with R/‐ genotype (n = 427, 72%). Patients with H/R had intermediate results under a codominant genetic inheritance model (HR: 0.72, P = 0.003). No significant associations were found between FCGR3A genotype and OS. In an exploratory analysis, patients with the combination of FCGR2A H/H + FCGR3A F/F genotype had significantly better OS (HR: 0.33, P = 0.003; median absolute benefit, 12.5 months) than patients with the combination of double‐variant R/R + V/V genotype. Progression‐free survival results were similar to OS. Toxicity rates were not associated with either polymorphism.ConclusionsThe FCGR2A genotype was associated with efficacy but not with toxicity in wild‐type KRAS, cetuximab‐treated colorectal cancer patients. FCGR3A genotype may modulate the relationship between FCGR2A polymorphism and outcome. FCGR2A is a promising biomarker for clinical management for these patients.
Structural Insight into H‐NOX Gas Sensing and Cognate Signaling Protein Regulation
Authors: Guo Yirui , Marletta Michael A. 
Published: October 2018

AbstractHeme‐nitric oxide/oxygen binding (H‐NOX) proteins are a family of gas‐binding hemoproteins that bind diatomic gas ligands such as nitric oxide (NO) and oxygen (O2). In bacteria, H‐NOXs are often associated with signaling partners, including histidine kinases (HKs), diguanylate cyclases (DGCs) or methyl‐accepting chemotaxis proteins (MCPs), either as a stand‐alone protein or as a domain of a larger polypeptide. H‐NOXs regulate the activity of cognate signaling proteins through ligand‐induced conformational changes in the H‐NOX domain and protein/protein interactions between the H‐NOX and the cognate signaling partner. This review summarizes recent progress toward deciphering the molecular mechanism of bacterial H‐NOX activation and the subsequent regulation of H‐NOX‐associated cognate sensor proteins from a structural and biochemical point of view.
Enhanced Supercapacitive Performance of MnCO3@rGO in an Electrolyte with KI as Additive
Authors: Li Hua , Wu Xiaozhong , Zhou Jin , Liu Yuxiang , Huang Ming , Xing Wei , Yan Zifeng , Zhuo Shuping 
Published: October 2018

AbstractMnCO3@rGO (GM) was synthesized through a facile one‐pot hydrothermal process with graphene oxide and KMnO4 as precursors. X‐ray diffraction analysis reveals that the prepared MnCO3 possesses a high crystallinity with a grain size of 28.4 nm. To improve the capacitive performance of GM, KI was added to the Na2SO4 electrolyte as a redox additive. Electrochemical measurements show that the specific capacitance of GM in KI additive electrolyte could reach up to 546 F g−1 at the current density of 0.5 A g−1. This value is 8 times larger than that (61 F g−1) in Na2SO4 electrolyte at the same current density. The elevated specific capacitance is attributed to the presence of I−, which can bring about significant pseudocapacitance through the redox couples of I−/I3− and I−/IO3− as confirmed by X‐ray photoelectron spectroscopy. GM also possesses a capacitance retention ratio of around 103 % after 2000 cyclic voltammetry measurements, suggesting a superior cycling stability.
Simultaneous Modulation of Composition and Oxygen Vacancies on Hierarchical ZnCo2O4/Co3O4/NC‐CNT Mesoporous Dodecahedron for Enhanced Oxygen Evolution Reaction
Authors: Ma Yangde , Yang Yang , Dai Xiaoping , Luan Xuebin , Yong Jiaxi , Qiao Hongyan , Zhao Huihui , Cui Meilin , Zhang Xin , Huang Xingliang 
Published: October 2018

AbstractElectrochemical water splitting is a promising way for the sustainable production of hydrogen, but the efficiency of the overall water‐splitting reaction largely depends on the oxygen evolution reaction (OER) because of its sluggish kinetics. Herein, a series of hierarchical ZnCo2O4/Co3O4/NC‐CNT (NC‐CNT=nitrogen‐rich carbon nanotube) mesoporous dodecahedrons grafted to carbon nanotubes have been synthesized from ZnCo bimetallic zeolitic imidazolate frameworks (ZnCo‐ZIFs) through sequential pyrolysis in nitrogen and mild oxidation in air. The simultaneous modulation of oxygen vacancies, composition, and hierarchical mesoporous architecture remarkably enhanced their electronic conduction and the amount and reactivity of accessible actives; thus boosting their intrinsic activity in the OER. The optimal ZnCo2O4/Co3O4/NC‐CNT‐700 sample exhibited a large current density of 50 mA cm−2 at a potential of 1.65 V, a small Tafel slope of 88.5 mV dec−1, and superior stability in alkaline media. This work should provide a facile strategy for the rational design of advanced OER catalysts by simultaneous engineering of oxygen vacancies and composition.
Stereoselective pharmacokinetics of (R)‐(+)‐ and (S)‐(−)‐rabeprazole in human using chiral LC‐MS/MS after administration of rabeprazole sodium enteric‐coated tablet
Authors: Sun Lu‐Ning , Shen Yi‐Wen , Ying Yu‐Wen , Li Duo , Li Teng‐Fei , Zhang Xue‐Hui , Zhao Ping , Ding Li , Wang Yong‐Qing 
Published: October 2018

AbstractRabeprazole is an effective proton pump inhibitor to treat acid‐related diseases. To achieve the simultaneous determination of rabeprazole enantiomers in human plasma, a chiral LC‐MS/MS method was developed and validated. Acetonitrile including 0.1% ammonium were used as protein precipitating agent. Analytes were separated within 8 minutes on a Chiralpak IC column (4.6 mm × 150 mm, 5 μm). The mobile phase was 10 mM ammonium acetate including 0.2% acetic acid‐acetonitrile (35:65, v/v). An API 4000 mass spectrometer was used as detector for the analysis, and the multiple reactions monitoring transitions of m/z 360.1 → 242.2 and 346.1 → 198.1 were opted for quantifying rabeprazole enantiomers and internal standard. Matrix effects were not apparent for each enantiomer and internal standard (esomeprazole), the calibration curves were linear over the concentration of 0.500 to 400 ng·mL−1, the intra‐run precisions were below 5.4%, the inter‐run precisions were below 9.9%, and the accuracy was between −9.2% and 9.3%. There was no chiral inversion observed during sample storage, preparation procedure, and analysis, demonstrating that analytes were stable in this study. This method was applied to the stereoselective pharmacokinetic study of (R)‐(+)‐ and (S)‐(−)‐rabeprazole after oral administration of 10‐mg rabeprazole sodium enteric‐coated tablet in healthy Chinese subjects.