bluuebunny/crossref_metadata_2025_split huggingface dataset:
A virtual reality-based self-guided training on identification of negative automatic thoughts in healthy adults: a mixed-methods feasibility study
Authors: Yang Bixi , Liao Chenxi , Yang Yuqing , Shi Binbin , Zhang Caidi , Li Chunbo 
Published: November 2024

BackgroundCognitive restructuring (CR) is an evidence-based psychological technique for depression. However, face-to-face CR is not easily accessible. Digital CR interventions often overlook the difficulties individuals experiencing depression encounter in identifying their negative automatic thoughts (NAT), leading to suboptimal outcomes. Virtual Reality (VR) has potential advantages in assisting the identification of NAT in CR intervention.ObjectiveThe aim of this preliminary feasibility study is to assess the efficacy, acceptability and safety of a VR-based self-guided training on the identification of negative automatic thoughts (VR-STINAT) for depression, as well as to evaluate the user experience.MethodsIn a mixed methods study, 20 healthy participants underwent VR-STINAT and completed a semi-structured interview, followed by post-training homework. The VR-STINAT includes three modules: psychological education, NAT identification training in VR scenarios, and practice in personally experienced scenarios. Effectiveness was measured via Thought Record Skills Assessment (TRSA) of homework and Cognitive Therapy Awareness Scale (CTAS). Acceptability was measured using an adapted Technology Acceptance Model and duration of training. Safety was measured via Simulator Sickness Questionnaire and self-reported negative emotions. Qualitative material was analyzed using thematic analysis.ResultsThe VR-STINAT was acceptable, with an average rating of 80.68%. The accuracy of NAT identification in TRSA reached 84.55%, and CTAS correctness reached 76.67%. The majority of participants experienced minimal or no side effects, although a few (10%, 2/20) reported relatively severe fatigue and craniofacial pain. Thematic analysis reviewed four themes: effectiveness, acceptability, advantages of VR, difficulties in use and suggestions for improvement. Most participants indicated that they’ve learned how to identify their NAT through VR-STINAT (85%, 17/20), which was engaging (90%, 18/20) and easy to use (60%, 12/20).ConclusionThis study provides preliminary evidence that self-guided training for the identification of negative automatic thoughts related to depression using VR is feasible. Future studies are needed to compare the efficacy of VR with other intervention modalities in people with depression.
Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image
Authors: Xiao Liu , Wen Xue , Li Lin , Li Yuhao 
Published: November 2024

PurposeBisphenol A (BPA) and its analogs have been proved to be harmful to human health. This study aimed to assess the correlation of BPA and its major analog, Bisphenol S (BPS), with metabolic parameters within main organs using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging.MethodsA retrospective analysis was conducted on patients who had undergone FDG PET/CT imaging and were also examined for BPA and BPS levels. Urine samples were collected for detection of BPA and BPS. Standardized uptake values (SUVmax and SUVmean) of main organ tissues including liver, blood, spleen, muscle, thyroid, and cerebral cortex were quantified. Statistical analysis was performed using Spearman’s rank correlation.ResultsForty patients (20 female, 20 male; mean age: 56.1 ± 15.4 years) were included. Mean urine BPA and BPS concentrations were 2.1 ± 1.2 ng/mL and 1 ± 0.6 ng/mL, respectively. Urine BPA exhibited a moderate positive correlation with liver SUVmax (r = 0.351, p = 0.026) and SUVmean (r = 0.361, p = 0.022) in male. No significant correlations were found between BPA and blood, muscle, spleen, thyroid, and cerebral cortex (p &gt; 0.05). Conversely, urine BPS demonstrated a negative correlation with thyroid SUVmax in male (r = −0.43, p = 0.012) and SUVmean (r = −0.432, p = 0.012), while a positive correlation was observed between BPS and cerebral cortex SUVmax in female (r = 0.366, p = 0.033).ConclusionUrinary levels of BPA and BPS exerted distinct influences on tissue metabolic parameters observed via FDG PET/CT imaging, particularly affecting the liver, thyroid, and cerebral cortex.
Development and validation of a nomogram for predicting motoric cognitive risk syndrome among community-dwelling older adults in China: a cross-sectional study
Authors: Yuan Huiqi , Jiang Ye , Li Yali , Bi Lisha , Zhu Shuhong 
Published: November 2024

BackgroundMotoric cognitive risk (MCR) syndrome is characterized by slow gait speed and subjective cognitive complaints (SCC) and increases the risk of dementia and mortality.ObjectiveThis study aimed to examine the clinical risk factors and prevalence of MCR in community-dwelling older adults, with the goal of developing and validating a nomogram model for developing prevention strategies against MCR.MethodsWe enrolled community-dwelling participants aged 60–85 years at Guangwai Community Health Service Center between November 2023 and January 2024. A total of 1,315 older adults who met the criteria were randomly divided into a training set (n = 920) and a validation set (n = 395). By using univariate and stepwise logistic regression analysis in the training set, the MCR nomogram prediction model was developed. The area under the receiver operator characteristic curve (AUC), calibration plots, and Hosmer-Lemeshow goodness of fit test were used to evaluate the nomogram model’s predictive performance, while decision curve analysis (DCA) was used to evaluate the model’s clinical utility.ResultsEducation, physical exercise, hyperlipoidemia, osteoarthritis, depression, and Time Up and Go (TUG) test time were identified as independent risk factors and were included to develop a nomogram model. The model exhibited high accuracy with AUC values of 0.909 and 0.908 for the training and validation sets, respectively. Calibration curves confirmed the model’s reliability, and DCA highlighted its clinical utility.ConclusionThis study constructs a nomogram model for MCR with high predictive accuracy, which provides a reference for large-scale early identification and screening of high-risk groups for MCR.
A meta-analysis of the efficacy of physical exercise interventions on activities of daily living in patients with Alzheimer's disease
Authors: Xiao Yang , Fan Yu , Feng Zhengteng 
Published: November 2024

ObjectiveThis study aimed to systematically review published randomized controlled trials on the effects of physical exercise on activities of daily living (ADL) in Alzheimer's patients through meta-analysis, thereby synthesizing existing evidence to provide scientific intervention recommendations for exercise prescriptions in Alzheimer's patients.MethodsBased on strict literature inclusion and exclusion criteria, a systematic search was conducted in databases including PubMed and Web of Science from their inception to July 1, 2024. The Cochrane risk assessment tool was used to evaluate the design of randomized controlled trials. Studies reporting on physical exercise interventions for ADL in Alzheimer's patients were systematically identified. Subgroup analyses and meta-regression were performed to explore sources of heterogeneity.ResultsNineteen articles, for analysis, providing 27 randomized controlled trials (RCTs). A random-effects model was used to calculate the effect size and 95% confidence interval for each independent study, and meta-analysis was performed using Stata 16.0 and RevMan 5.4 software. The results showed that physical exercise might significantly improve ADL in Alzheimer's patients (SMD = 0.33, 95% CI: 0.12–0.54, I2 = 81.7%). Sensitivity analysis confirmed the robustness of the results (p &gt; 0.05). Egger's test did not reveal significant publication bias (p = 0.145). Samples were divided into different subgroups based on intervention content, duration, frequency, and session length. Subgroup analysis based on intervention characteristics showed that resistance training or aerobic exercise (SMD = 0.83, 95% CI: 0.60–1.05), long-term interventions (&gt;6 months, SMD = 0.31, 95% CI: 0.13–0.49), medium-frequency interventions (4-5 times per week, SMD=0.39, 95% CI: 0.23-0.55), and short-duration training ( ≤ 30 min, SMD = 0.96, 95% CI: 0.71–1.21) might be most effective in enhancing ADL in Alzheimer's patients. These improvements were not only statistically significant but also had substantial impact in clinical practice.ConclusionResistance training or aerobic exercise lasting more than 6 months, 4–5 times per week, and lasting no more than 30 min per session may be most effective in improving ADLs in patients with Alzheimer's disease.
Возможности использования интраокулярной коррекции со сложной оптикой у пациентов с эпимакулярным фиброзом
Authors: Д.М. Губжокова , А.А. Плюхова , Н.Ю. Юсеф , Д.В. Петрачков 
Published: November 2024

Эпимакулярный фиброз является распространенной патологией сетчатки и приводит к снижению максимальной корригированной остроты зрения и потере контрастной чувствительности. Существует множество классификаций данного заболевания, но наибольшее распространение получила классификация Гасса. Жалобы пациентов зависят от типа и стадии процесса. Обычно отмечают метаморфопсии, микропсии или макропсии, фотопсии, снижение остроты зрения, диплопию и потерю центрального зрения. Хирургическое лечение эпимакулярного фиброза включает в себя витрэктомию, удаление эпиретинальной мембраны и устранение натяжения сетчатки. Иногда витрэктомия сочетается с одномоментным удалением катаракты – факоэмульсификацией, включающей имплантацию интраокулярной линзы (факовитрэктомия). В описании к использованию мультифокальной интраокулярной линзы заболевания сетчатки являются противопоказанием для установки данных линз. Но поскольку средняя продолжительность жизни увеличивается и многие пациенты продолжают свою трудовую деятельность, ведут активный образ жизни, а прогрессирование одной из самых частых макулярных патологий – эпимакулярного фиброза встречается все чаще, возможность применения нового типа интраокулярной линзы с углубленным фокусом – EDOF является, несомненно, актуальной.
Epimacular fibrosis is a common pathology of the retina and leads to a decrease in MCOZ and loss of contrast sensitivity. There are many classifications of this disease, but the most widespread classification is Gass. Patient complaints depend on the type and stage of the process. Patients usually report metamorphopsies, micropsies or macropsies, photopsies, decreased visual acuity, diplopia and loss of central vision. Surgical treatment of epimacular fibrosis includes vitrectomy, removal of the epiretinal membrane and removal of retinal tension. Sometimes vitrectomy is combined with simultaneous cataract removal- phacoemulsification, including implantation of an intraocular lens (phacovitrectomy). In the description of the use of multifocal IOL, retinal diseases are a contraindication for the installation of these lenses. But, since the average life expectancy is increasing and many of the patients continue their work, lead an active lifestyle, and the progression of one of the most common macular pathologies – epimacular fibrosis is becoming more common, the possibility of using a new type of IOL with an in-depth focus – EDOF is undoubtedly relevant.
ВЛИЯНИЕ РЯДА ПРОИЗВОДНЫХ 1,4-ДИКАРБОНОВЫХ КИСЛОТ НА ВРЕМЯ СВЕРТЫВАНИЯ КРОВИ
Authors: Н.В. Колотова , А.В. Старкова 
Published: November 2024

Исследовано влияние шести монозамещенных амидов и восьми ацилгидразидов янтарной, малеиновой, цитраконовой и фталевой кислот на гемостаз на коагулометре АПГ4-02-П. Опыты проводили на цитратной (3,8%) крови (9:1) кроликов. Для определения активности в кювету помещали 50 мкл крови и добавляли 50 мкл 0,2% раствора исследуемого соединения. В контроле вместо вещества добавляли 50 мкл изотонического раствора хлорида натрия. В качестве препарата сравнения использовали 50 мкл гепарина в концентрации 1 ЕД/мл крови или 50 мкл раствора препарата «Этамзилат» в концентрации 0,2%. Степень влияния соединений на гемостаз определяли по изменению времени свертывания цитратной крови в контроле и опыте. Из 14 исследованных производных 1,4-дикарбоновых кислот 10 соединений оказали влияние на гемостаз. Пять соединений проявили антикоагулянтный эффект. Гемостатическое действие проявили пять соединений. Эффект двух соединений аналогичен действию препарата «Этамзилат».
The effect of six monosubstituted amides and eight acylhydrazides of succinic, maleic, citraconic and phthalic acids on hemostasis on the coagulometer APG4-02-P was studied. The experiments were performed on citrated (3.8%) blood (9:1) rabbits. To determine the activity, 50 μl of blood was placed in the cuvette and 50 μl of a 0.2% solution of the test compound was added. In the control, instead of the substance, 50 μl of isotonic sodium chloride solution was added. As the reference preparation, 50 μl of heparin was used at a concentration of 1 U/ml of blood or 50 μl of a solution of the preparation Etamsilat at a concentration of 0.2%. The degree of influence of the compounds on hemostasis was determined by the change in the clotting time of citrated blood in the control and experiment. Of the fourteen studied derivatives of 1,4-dicarboxylic acids, ten compounds had an effect on hemostasis. Five compounds exhibited anticoagulant effects. Five compounds exhibited a hemostatic effect. The effect of the two compounds is similar to that of Etamsilat.
НЕКОТОРЫЕ ВОПРОСЫ ФАРМАЦЕВТИЧЕСКОЙ РАЗРАБОТКИ ИНТРАВАГИНАЛЬНОЙ ЛЕКАРСТВЕННОЙ ФОРМЫ С ЭКСТРАКТОМ ХМЕЛЯ ОБЫКНОВЕННОГО
Authors: Г.В. Аюпова , Г.М. Латыпова , Ю.Л. Борцова , Е.Д. Батырова , Р.М. Киреева , Р.Г. Баламетова 
Published: November 2024

Представлены результаты исследований по разработке технологической схемы производства и изучения антиоксидантной активности интравагинальной лекарственной формы. Исследования методом хемилюминесценции продемонстрировали прямое антиоксидантное действие, снижение процессов образования свободных радикалов в модельных системах.
The paper presents the results of the studies on development of technological scheme of production and study of antioxidant activity of intravaginal drug form. Research by the chemiluminescence method has demonstrated direct antioxidant effect reduction of free radical formation processes of formation of free radicals in model systems.
ОЦЕНКА СОДЕРЖАНИЯ БИОЛОГИЧЕСКИ-АКТИВНЫХ ВЕЩЕСТВ В СВЕЖЕМ И ВЫСУШЕННОМ СЫРЬЕ БАЗИЛИКА КАМФОРНОГО (OCIMUM BASILICUM L.)
Authors: Н.В. Нестерова , К.И. Кравчук , В.Ю. Ермакова , Н.В. Бирюкова , Д.А. Доброхотов 
Published: November 2024

В данной работе авторами было проведено качественное и количественное определение ряда известных групп билогически-активных веществ, таких как эфирные масла, полифенолы и антоцианы. Качественный анализ проводился характерными качественными реакциями и методом тонкослойной хроматографии. Количественная оценка исследуемых групп, проводилась известными фармакопейными методами (эфирные масла, антоцианы) и методом Фолина-Чокальтеу, широко применяемом в пищевой промышленности (полифенолы). Максимальный выход веществ характерен для свежего сырья базилика Перечного, в котором содержание эфирного масла составило 0,82%, полифенольных соединений - 6,42%, антоцианов - 0,560%
In this article the authors conducted a qualitative and quantitative determination of a number of known groups of bilogically active substances, such as essential oils, polyphenols and anthocyanins. Qualitative analysis was performed using characteristic qualitative reactions and thin-layer chromatography. Quantitative evaluation of the groups studied was carried out using well-known Pharmacopoeia methods (essential oils, anthocyanins) and the Follin – Chicalteu method, which is widely used in the food industry (polyphenols). The maximum yield of substances is typical for fresh raw materials of Pepper Basil, in which the content of essential oil was 0.82%, polyphenolic compounds – 6.42%, anthocyanins – 0.560%.
ТРЕХМЕРНАЯ АДДИТИВНАЯ ПЕЧАТЬ В ТЕХНОЛОГИИ ЛЕКАРСТВЕННЫХ ФОРМ
Authors: К.В. Алексеев , Е.В. Блынская , С.В. Тишков , А.А. Иванов , В.К. Алексеев 
Published: November 2024

Аддитивные технологии (трехмерная печать) - сегодня наиболее развивающееся направление в различных сферах и отраслях. В фармацевтической отрасли этот вид производства тесно связан с концепцией персонифицированной медицины, где на основании личных данных пациента создается лекарственная форма с индивидуальными характеристиками. В обзоре представлен ряд технологий трехмерной печати с классификацией по физическому принципу работы различных видов 3D-принтеров. Описаны принцип действия, характеристики, преимущества и недостатки таких видов 3D-печати, как экструзионная печать, порошковая печать (TheriForm) и стереолитография. Продемонстрированы особенности применения трехмерной печати в таких лекарственных формах, как имплантаты, таблетки и трансдермальные системы доставки (пластыри с микроиглами). Сделан вывод о приемлемости трехмерной печати в фармацевтической технологии, показаны перспективы развития, необходимые условия для формирования нормативной базы и внедрения принципов аддитивного производства лекарственных форм в повседневную практику.
Additive technologies (three-dimensional printing) are currently the most developing area in various fields and industries. In pharmaceutical technology, this type of production is closely related to the concept of personalized medicine, where a dosage form with individual characteristics is created on the basis of the patients personal data. This literature review presents various 3D printing technologies with physical classification of different types of 3D printers. The principle of operation, characteristics, advantages and disadvantages of such types of 3D printing as extrusion printing, powder printing (TheriForm) and stereolithography are described. Demonstrated features of the use of three-dimensional printing in such dosage forms as: implants, tablets and transdermal delivery systems (patches with microneedles). The conclusion is made about the acceptability of three-dimensional printing to pharmaceutical technology, the development prospects and the necessary conditions for the formation of a regulatory framework and the introduction of the principles of additive production of dosage forms in everyday practice.
ИССЛЕДОВАНИЕ И РАЗРАБОТКА ГЕПАТОПРОТЕКТОРНОГО СРЕДСТВА
Authors: Е.В. Ферубко 
Published: November 2024

Разработано многокомпонентное растительное средство под условным названием «Пентафит». В результате проведенных экспериментов установлено, что его курсовое введение per os в дозе 300 мг/кг нелинейным крысам с экспериментальными повреждениями печени оказывает антигепатотоксическое, гепатопротективное и мембраностабилизирующее действие.
A multicomponent plant agent under the conditional name "Pentafite" has been developed. As a result of the experiments carried out, it was found that its course administration per os at a dose of 300 mg/kg to nonlinear rats with experimental liver injuries has antihepatotoxic, hepatoprotective and membrane stabilizing effect.
РОССИЙСКИЕ ИСПЫТАТЕЛЬНЫЕ ЦЕНТРЫ: АСПЕКТЫ РАЗРАБОТКИ СИСТЕМ МЕНЕДЖМЕНТА КАЧЕСТВА ДЛЯ ВНЕДРЕНИЯ ПРИНЦИПОВ НАДЛЕЖАЩЕЙ ЛАБОРАТОРНОЙ ПРАКТИКИ
Authors: А.А. Таубэ , А.А. Шарафиева , Л.В. Шигарова , Е.В. Флисюк , А.В. Москвин 
Published: November 2024

На основании анализа документов предложены 11 практических шагов по внедрению в деятельность испытательных центров, проводящих неклинические исследования лекарственных средств в соответствии с требованиями ГОСТ Р ИСО 9001-2015. Даны рекомендации для руководства и ответственных за внедрение в лаборатории стандартов ИСО. Внедрение системы менеджмента качества в соответствии со стандартами ISO серии 9000 (ГОСТ Р ИСО 9000-2015) является первым этапом подготовки испытательного центра к внедрению требований надлежащей лабораторной практики. Российские лаборатории, проводящие неклинические испытания на этапе разработки лекарственных средств, могут достичь значительных успехов, внедряя требования международного стандарта ISO 9001 в свою деятельность. На основе стандартов ИСО серии 9000 сформированы основные этапы по созданию системы менеджмента качества (СМК) в лаборатории, проводящей доклинические исследования.
Based on the analysis of the documents, 11 practical steps were proposed to introduce the requirements of GOST R ISO 9001-2015 into the activities of testing centers conducting non-clinical trials of drugs. Recommendations are given for the management and those responsible for the implementation of ISO standards in the laboratory. Based on the analysis of the requirements of international standards ISO 9001:2015 and GLP, it can be concluded that the decision to implement a quality management system in accordance with the ISO 9001 series (GOST R ISO 9001-2015) as the first stage of certification of a testing center for compliance with the requirements of an appropriate laboratory practice. Russian laboratories conducting non-clinical trials at the stage of drug development can achieve significant success by implementing the requirements of the international standard ISO 9001 in their activities. Based on ISO 9001 standards, steps are proposed to create a Quality Management System in an organization conducting preclinical research: management commitment and appointment of a quality representative, training of employees in ISO 9001, initial state analysis and planning, development of documents at appropriate levels, monitoring of implementation processes and audit.
ОСОБЕННОСТИ ФАРМАЦЕВТИЧЕСКОЙ РАЗРАБОТКИ ТАБЛЕТОК НА ОСНОВЕ СУХИХ ЭКСТРАКТОВ
Authors: А.В. Фотеева , М.П. Чугунова , Н.А. Прозорова , П.Н. Вшивков 
Published: November 2024

Определение критических параметров технологического процесса является одним из важных аспектов фармацевтической разработки лекарственных препаратов стабильно высокого качества. Цель данной работы - выявление факторов, потенциально способных оказать влияние на качество и стабильность таблетированного лекарственного препарата, содержащего сухой экстракт алтея, - «Мукалтин, таблетки 50 мг». Для определения параметров, являющихся критическими при производстве таблеток мукалтина, было проведено изучение влияния ряда факторов на стабильность препарата в процессе хранения: влажность исходных компонентов; остаточная влажность готовой таблетки; физико-химические свойства вспомогательного компонента (изомерия винной кислоты); материал первичной упаковки. В ходе проведенного исследования установлено, что из изученных факторов к критическим параметрам процесса производства таблеток мукалтина относятся: влажность полупродуктов и готового продукта и материал упаковки.
The determination of critical process parameters is one of the most important development studies of the drug products which quality is consistently high. The purpose of this work is to identify the factors that can potentially affect the quality and stability of the drug product "Mukaltin, tablets 50 mg", containing althea dry extract. To determine the critical parameters of the manufacturing process of mucaltin tablets there were carried out some stability studies. We've studied the influence of different factors on the stability of this drug product during its storage. They are the humidity of the starting materials, the residual humidity of the finished product, physical and chemical properties of the excipient (isomerism of tartaric acid) and primary packaging material. During these studies it was revealed that such factors as the humidity of the intermediates and of the finished product and also the packaging material should be included to the critical process parameters.