bluuebunny/crossref_metadata_2025_split huggingface dataset:
FARFAR2: Improved de novo Rosetta prediction of complex global RNA folds
Authors: Watkins Andrew M. , Das Rhiju 
Published: September 2019

SummaryMethods to predict RNA 3D structures from sequence are needed to understand the exploding number of RNA molecules being discovered across biology. As assessed during community-wide RNA-Puzzles trials, Rosetta’s Fragment Assembly of RNA with Full-Atom Refinement (FARFAR) enables accurate prediction of complex folds, but it remains unclear how much human intervention and experimental guidance is needed to achieve this performance. Here, we present FARFAR2, a protocol integrating recent innovations with updated RNA fragment libraries and helix modeling. In 16 of 21 RNA-Puzzles revisited without experimental data or expert intervention, FARFAR2 recovers structures that are more accurate than the original models submitted by our group and other participants during the RNA-Puzzles trials. In five prospective tests, pre-registered FARFAR2 models for riboswitches and adenovirus VA-I achieved 3–8 Å RMSD accuracies. Finally, we present a server and three large model archives (FARFAR2-Classics, FARFAR2-Motifs, and FARFAR2-Puzzles) to guide future applications and advances.
Estimating the price range and the effect of price bundling strategies
Authors: Dominique-Ferreira Sérgio , Antunes Cristina 
Published: September 2019

PurposeThe purpose of this paper is to investigate and identify the price sensitivity of consumers of three- and five-star hotels and to determine the impact of bundling strategies on consumers’ price sensitivity.Design/methodology/approachTo calculate price sensitivity, authors apply the van Westendorp’s price sensitivity meter (PSM). To understand the impact of bundling strategies, univariate and bivariate techniques are applied.FindingsPSM results reveal the optimal prices and the range of acceptable prices for three- and five-star hotel. The bundling strategy results reveal that five-star customers are less sensitive to mixed-leader bundling. Regarding mixed-joint bundling, managers could improve sales through bundling strategies if they selected an attractive service (e.g. restaurants).Practical implicationsFindings assist hotel managers to understand the different price sensitivities, according to the hotel typology. Managers can manage prices without the risk of losing market share or revenue. The results help managers in deciding which bundling strategies they can create, as well as the services to be included to achieve highest profitability.Originality/valueNo research to date to the best of the authors’ knowledge has attempted to understand and compare the role of bundling strategies in three- and five-stars hotels. Moreover, no research has attempted to measure and compare customers’ price sensitivity of three- and five-stars hotels.
Negative outcomes of positive brand relationships
Authors: Jain Kokil , Sharma Isha 
Published: September 2019

Purpose
This paper aims to understand how strong brand attachment can intensify the feeling of perceived betrayal, leading to brand hate after a negative experience with the brand. The study further investigates how consumers make causal attributions for negative experiences when strong brand attachment exists. The moderating effect of a narcissistic personality in the dissemination of negative electronic word of mouth (eWOM) following brand hate is also tested.

Design/methodology/approach
The study uses a within-the-subject repeated measures experimental design. A total of 202 college students were exposed to two treatments (high versus no brand attachment), involving a situation of product failure of a smart phone brand. A total of 135 responses were used to compare the outcomes of the two treatments using multivariate analysis. The data of high brand attachment treatment (N = 202) were used to test the proposed research model using partial least square-structural equation modelling.

Findings
The results suggest that having a strong positive relationship with the brand can generate stronger feelings of perceived betrayal and brand hate after the brand transgresses the consumer’s expectations. The results indicate that resentful customers can resort to eWOM after feeling betrayed, even though the prior relationship with the brand was strong.

Originality/value
This paper extends the work on perceived betrayal to study brand hate and proposes that brand hate can arise even if there is a strong brand attachment. It contributes to the growing body of literature on brand hate and its possible antecedents. Additionally, the study poses some crucial managerial implications for the brand managers by suggesting that strong brand relationships not always ensure loyalty or commitment and can lead to consequences that are damaging for the brand equity.
Burned-N-Turned: feeding the fracking boom
Authors: Anderson Beauvais R. , Anderson Joe , Williams Susan K. 
Published: September 2019

Theoretical basis
The discussion questions relating to the case focus students’ attention on breaking away from the intuitive/emotional “boom mentality” driving their business decision and ask them to focus more on analytical decision criteria to support their “go” or “no-go” decisions.

Research methodology
The authors interviewed one of the partners of Burned-N-Turned several times and read the partners’ brief business plan for the food trailer.

Case overview/synopsis
Partners are wrapped up in the “boom mentality” in the Bakken oil fields in 2011 and jump into their decision to open a food trailer restaurant to serve the oil field workers and others. But have they omitted important considerations for their business decision?

Complexity academic level
The study is appropriate for undergrad strategic management courses. The authors have tested the compact case in three sections of capstone senior-level strategic management courses.
Building, leading, and sustaining a cultural enterprise: Martin Guitar in 2019
Authors: Kushner Roland J. 
Published: September 2019

Theoretical basis
The case includes theoretical references to family business, organizational culture, resource-based value and leadership.

Research methodology
The case combines primary and secondary data. There is ample public information about Martin Guitar including histories of the company and its instruments. These were used for background. Primary data were provided by the company in the form of customized data and interviews.. The case writer has served Martin Guitar as a consultant and also plays Martin instruments. The case writer had numerous opportunities to interview Chris and his key lieutenants.

Case overview/synopsis
In 2019, C.F. Martin IV (Chris) was in his fourth decade leading one of the America’s oldest family-owned companies, C.F. Martin & Co., Inc. Martin Guitar is a globally known maker of fine guitars that are prized by collectors, working musicians and amateur musicians. Chris was raised in the family business and took on the CEO’s position at the age of 30. The case describes the company’s management practices and the culture that has emerged from them. In 2019, at age 64, Chris confronted issues faced by his predecessors over multiple generations: how to prepare the company for succession, and maintain its strong performance as a family-owned company in a dynamic industry environment.

Complexity academic level
The case is designed for a management course for upper-level undergraduates.
Avian vulnerability to wind farm collision through the year: Insights from lesser black‐backed gulls (Larus fuscus) tracked from multiple breeding colonies
Authors: Thaxter Chris B. , Ross‐Smith Viola H. , Bouten Willem , Clark Nigel A. , Conway Greg J. , Masden Elizabeth A. , Clewley Gary D. , Barber Lee J. , Burton Niall H. K. 
Published: September 2019

AbstractWind energy generation has become an important means to reduce reliance on fossil fuels and mitigate against human‐induced climate change, but could also represent a significant human–wildlife conflict. Airborne taxa such as birds may be particularly sensitive to collision mortality with wind turbines, yet the relative vulnerability of species’ populations across their annual life cycles has not been evaluated.Using GPS telemetry, we studied the movements of lesser black‐backed gullsLarus fuscusfrom three UK breeding colonies through their annual cycle. We modelled the distance travelled by birds at altitudes between the minimum and maximum rotor sweep zone of turbines, combined with the probability of collision, to estimate sensitivity to collision. Sensitivity was then combined with turbine density (exposure) to evaluate spatio‐temporal vulnerability.Sensitivity was highest near to colonies during the breeding season, where a greater distance travelled by birds was in concentrated areas where they were exposed to turbines.Consequently, vulnerability was high near to colonies but was also high at some migration bottlenecks and wintering sites where, despite a reduced sensitivity, exposure to turbines was greatest.Synthesis and applications. Our framework combines bird‐borne telemetry and spatial data on the location of wind turbines to identify potential areas of conflict for migratory populations throughout their annual cycle. This approach can aid the wind farm planning process by: (a) providing sensitivity maps to inform wind farm placement, helping minimize impacts; (b) identifying areas of high vulnerability where mitigation warrants exploration; (c) highlighting potential cumulative impacts of developments over international boundaries and (d) informing the conservation status of species at protected sites. Our methods can identify pressures and linkages for populations using effect‐specific metrics that are transferable and could help resolve other human–wildlife conflicts.
Body shape is related to the attempt rate and passage success of brook trout at in‐stream barriers
Authors: Goerig Elsa , Wasserman Ben A. , Castro‐Santos Theodore , Palkovacs Eric P. 
Published: September 2019

Abstract

The ability to move between habitats has important implications for fitness in many species. In‐stream barriers such as culverts can impede movements of riverine fishes and thus reduce connectivity between habitats. The ability of fish to overcome barriers is related to the features of the environment and the barrier itself, but also to physiological, morphological and behavioural traits of the fish. Among these, body shape varies among and within species, and influences swimming ability, a key component of passage performance through culverts.

We conducted an experimental study on wild brook trout (Salvelinus fontinalis) to assess the effects of individual body shape on attempt rate and passage success through culverts on six streams.

A more streamlined body shape was associated with an increased motivation to enter and ascend the culverts, and, to a lesser extent, with the probability of successful passage once an attempt was staged. Motivation and successful passage were also influenced by the density of conspecifics below the culvert, time of day, fish body size and water velocity.

Policy implications. While fish body shape is expected to influence swimming performance, our research shows the most important effect of body shape to be on an individual's motivation to stage passage attempts at culverts. This study points to an important connection between behaviour and morphological traits that influence passage success and suggests that in‐stream barriers may be an important agent of selection on behaviour and morphology in wild fish populations.
Education as Transformation: Formalism, Moralism and the Substantivist Alternative
Authors: Yacek Douglas , Ijaz Kailum 
Published: September 2019

Abstract
The term ‘transformation’ and its cognates can be found appended to almost every key term in the contemporary educational lexicon. In educational psychology, teachers are urged to adopt the methods of ‘transformational teaching’. In adult education, the theory of ‘transformative learning’ defines the current research paradigm. Social justice educators regularly couch their consciousness-raising efforts in terms of ‘transformative pedagogy’. And in philosophy of education, pragmatists, phenomenologists, neo-Aristotelians and postmodernists alike point to the special transformative quality of education, both in the Anglo-American as well as the German-language discourses. In this essay, we argue that these various conceptions of transformative education can be organised under two theoretical categories, each with its own distinctive understanding of and approach to creating transformative educational experiences: formalism and moralism. In the first two sections, we discuss the characteristic qualities of these two approaches and point to several problems that arise within them. Drawing on recent developments in the philosophy of language and moral psychology, we then advance a ‘substantivist’ alternative to the formalistic and moralistic approaches, which characterises the transformative experience as a process of renarrativation with two experiential moments: articulation and aspiration. Substantivism is an attractive approach to transformative education, we argue in the final section, because it avoids the problems that arise in the formalistic and moralistic conceptions while providing resources for capturing what is essential to transformative experience in the educational process.
Functionalized AuMBA@Ag Nanoparticles as an Optical and SERS Dual Probe in a Lateral Flow Strip for the Quantitative Detection of Escherichia coli O157:H7
Authors: Liu Hai‐bin , Chen Chun‐yang , Zhang Chen‐ning , Du Xin‐jun , Li Ping , Wang Shuo 
Published: September 2019

AbstractA method combining surface‐enhanced Raman scattering (SERS) with a lateral flow strip (LFS) was developed for the quantitative and sensitive analysis of Escherichia coli O157:H7. AuMBA@Ag nanoparticles were prepared as SERS probes, and 4‐methylthiobenzoic acid (MBA) as a Raman reporter was inserted into the interior gap of the Au@Ag core‐shell nanoparticles, which replaced the Au nanoparticles that serve as SERS nanotags in traditional LFS. Using this developed SERS‐LFS, the presence of the target bacteria could be tested through the appearance of a red band on the test line. Furthermore, quantitative analysis of E. coli O157:H7 was achieved by measuring the specific Raman intensity of MBA on the test line. The sensitivity of this SERS‐LFS biosensor is 5 × 104 CFU/mL of E. coli O157:H7, which is 10‐fold higher than that of a naked eye‐based colorimetric LFS. This quantitative detection of E. coli O157:H7 (= 1993.86 − 6812.17, R2 = 0.9947) was obtained with a wide linear range (5 × 104 to 5 × 108) due to the signal enhancement of the SERS nanotags. In addition, the SERS‐LFS could differentiate E. coli O157:H7 from closely related bacterial species or nontarget contaminants, suggesting high specificity of this assay. The applicability of SERS‐LFS to the analysis of E. coli O157:H7 in milk, chicken breast, and beef was also validated, indicating that the sensitivity was not disturbed by the food matrix. In summary, the SERS‐LFS developed in this study could be a powerful tool for the quantitative and sensitive screening of E. coli O157:H7 in a food matrix.Practical ApplicationThis study demonstrates that a surface‐enhanced Raman scattering (SERS)‐based lateral flow strip (LFS) could be used as a rapid and sensitive method for Escherichia coli O157:H7 detection. Furthermore, this SERS‐based LFS could achieve quantitative detection of the target, eliminating the defect of the traditional colloidal gold LFS, which is not quantifiable.
The role of the national institutional environment in IFRS convergence: a new approach
Authors: Cao June , Patel Chris 
Published: September 2019

AbstractThis study uses an ideal setting to capture the influence of the national institutional environment on outcomes (i.e., earnings quality) of IFRS convergence using a within‐country approach. We show that earnings quality in terms of discretionary accruals and persistence has increased, while conservatism has decreased after IFRS convergence. The results are more pronounced in companies with a strong institutional environment. Our results are robust after considering incentives and other confounding factors. Our findings show differences in earnings quality in firms within a country adopting the same standards, let alone in firms worldwide. This indicates the context embeddedness of accounting standards.
Death spiral PIPEs: a reconsideration of the evidence
Authors: Benson Karen , Linnenluecke Martina K. , Morrison David , Rosov Sviatoslav 
Published: September 2019

AbstractWe challenge the view that PIPEs lead to unfavourable outcomes for issuing firms. We show that structured PIPEs do not have significant negative CARs when a matched firm benchmark is used for computing CARs and when sample selection bias is taken into account. Indeed, structured PIPEs have significantly higher positive skewness, indicating superior optionality, consistent with the real option argument. We also show that the 2002 intervention by the Securities and Exchange Corporation (SEC) has led to unintended consequences, with the substitution of ‘mom and pop’ investors for hedge fund investors in the structured PIPE market.
Association of parental substance use disorder with offspring cognition: a population family‐based study
Authors: Khemiri Lotfi , Larsson Henrik , Kuja‐Halkola Ralf , D'Onofrio Brian M. , Lichtenstein Paul , Jayaram‐Lindström Nitya , Latvala Antti 
Published: September 2019

AbstractAimsTo assess whether parental substance use disorder (SUD) is associated with lower cognitive ability in offspring, and whether the association is independent of shared genetic factors.DesignA population family‐based cohort study utilizing national Swedish registries. Linear regression with increased adjustment of covariates was performed in the full population. In addition, the mechanism of the association was investigated with children‐of‐sibling analyses using fixed‐effects regression with three types of sibling parents with increasing genetic relatedness (half‐siblings, full siblings and monozygotic twins).Setting and participantsA total of 3 004 401 people born in Sweden between 1951 and 1998.MeasurementsThe exposure variable was parental SUD, operationalized as having a parent with life‐time SUD diagnosis or substance‐related criminal conviction in the National Patient Register or Crime Register, respectively. Outcomes were cognitive test score at military conscription and final school grades when graduating from compulsory school. Covariates included in the analyses were sex, birth year, parental education, parental migration status and parental psychiatric comorbid diagnoses.FindingsIn the full population, parental SUD was associated with decreased cognitive test stanine scores at conscription [4.56, 95% confidence interval (CI) = 4.55–4.57] and lower Z‐standardized school grades (−0.43, 95% CI = –0.43 to –0.42) compared to people with no parental SUD (cognitive test: 5.17, 95% CI = 5.17–5.18; grades: 0.09, 95% CI = 0.08–0.09). There was evidence of a dose–response relationship, in that having two parents with SUD (cognitive test: 4.17, 95% CI = 4.15–4.20; grades: −0.83, 95% CI = −0.84 to –0.82) was associated with even lower cognitive ability than having one parent with SUD (cognitive test: 4.60, 95% CI = 4.59–4.60; grades: −0.38, 95% CI = −0.39 to –0.380). In the children‐of‐siblings analyses when accounting for genetic relatedness, these negative associations were attenuated, suggestive of shared underlying genetic factors.ConclusionsThere appear to be shared genetic factors between parental substance use disorder (SUD) and offspring cognitive function, suggesting that cognitive deficits may constitute a genetically transmitted risk factor in SUD.
Is rural mental health workforce a policy imperative?
Authors: Roberts Russell , Maylea Chris 
Published: September 2019

AbstractAn available and effective rural mental health workforce is critical to the provision of contemporary mental health care. During the last 5 years new mental health plans and strategies have been released every state and territory of Australia. This policy analysis examines the extent to which workforce, and particularly rural workforce issues are considered in these policies. The analysis revealed that rural workforce issues receive scant attention in state and territory mental health plans. Rural Australians comprise 28% of the total population, yet rural workforce issues are canvased, on average only 6% of the time general workforce issues are addressed. National mental health workforce plans do focus on the rural workforce, but these are not referenced in the state or territory strategies or workforce plans. Given the rural mental health workforce shortages, and consumer challenges in accessing rural mental health services, more planning and consideration to supporting and developing a rural workforce appears warranted.
Psychology of Mystical Experience: Muḥammad and Siddhārtha
Authors: Galadari Abdulla 
Published: September 2019

AbstractA comparison between Muḥammad and Siddhārtha's psychological states is made to identify how they had their mystical experiences and how their presuppositions and personalities shaped their interpretation of these experiences. Muḥammad's mystical experience appeared to be based on an altered state of consciousness. Siddhārtha's teachings include that one must not have blind faith and remain open to various truths. These teachings may reflect that he was high in openness to experience, which may have fortified him from becoming delusional. While mystical experiences may have pathological overlaps, they could be categorized in a similar way to psychological states. Yet, mindful presuppositions and personality traits, especially from within openness to experience spectrum, are what make perceptions of these experiences diverse.