bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of mindfulness-based interventions for patients with COPD: a systematic review and meta-analysis protocol
Authors: Tian Lingyun , Zhang Ying , Li Li , Wu Ying , Li Yinglan 
Published: May 2019

IntroductionChronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease. It has adverse effects on patients’ physical health, mental well-being and quality of life. The purpose of mindfulness-based interventions (MBIs) is to raise non-judgemental awareness and attention to current internal and external experiences. This means the attention is shifted from perceived and involuntary inner activities to current experience, keeping more curious, open and accepting attitudes towards current experience. Although some studies on the intervention effect of MBIs in patients with COPD have been conducted, the results are controversial, especially on dyspnoea, level of mindfulness and quality of life. Therefore, a systematic review of MBIs in patients with COPD is required to provide available evidence for further study.Methods and analysisIn this study, different studies from various databases will be involved. Randomised controlled trials(RCTs)/quantitative studies, qualitative studies and case studies on the effect of MBIs in patients with COPD aged over 18 years will be included. We will search the literature in the databases of PubMed, Excepta Medica Base (EMBASE), Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, PsycINFO and China National Knowledge Infrastructure(CNKI). The primary outcomes will include efficacy of MBIs for patients with COPD in terms of dyspnoea, depression and anxiety. The secondary outcomes will include efficacy of MBIs in terms of quality of life, mindful awareness, 6-minute walk test(6MWT) and nutritional risk index. Data extraction will be conducted by two researchers independently, and risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0.Ethics and disseminationSince this study is a systematic review, the findings are based on the published evidence. Therefore, examination and agreement by the ethics committee are not required in this study. We intend to publish the study results in a journal or conference presentations.PROSPERO registration numberCRD42018102323.
Auricular points acupressure for insulin resistance in overweight/obese women with polycystic ovary syndrome: protocol for a randomised controlled pilot trial
Authors: Li Yan , Hou Lihui , Wang Yingji , Xie Liangzhen , Zhang Meiwei , Pan Zimeng , Li Yangyang , Ding Yicheng , Sun Miao , Qu Yufang , Liu Songjiang 
Published: May 2019

IntroductionApproximately 5%–20% of reproductive women suffer from polycystic ovary syndrome (PCOS). Auricular points acupressure (AA) may serve as alternative management for PCOS for its benefits in both physical and psychological well-being. However, the effects of AA for insulin resistance (IR) in overweight/obese PCOS women have not been confirmed.Methods and analysisThe present study is designed as a randomised, placebo-controlled pilot trial to evaluate the effectiveness and safety of AA in treating IR in women with PCOS. A total of 60 eligible PCOS subjects will be randomised into an intervention group (AA group) and a control group (sham AA group) in a ratio of 1:1. Magnetic beads will be taped to the auricular points by the same senior acupuncture specialist from the First Affiliated Hospital, Heilongjiang University of Chinese Medicine. The treatment will last for 12 weeks. Primary outcome measure will be changes in homeostasis model assessment of IR between baseline and after 3 months of AA/sham AA treatment. Secondary outcomes include hormonal profile, weight, waist/hip circumference, body mass index, blood pressure, Ferriman-Gallwey score, acne and the assessment of health-related quality of life. Outcome measures are collected at baseline and the end of treatment visit.Ethics and disseminationThe protocol has been approved by the ethics committee of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine (HZYLLKY201800301). Written informed consent will be obtained from all participants. The results will be disseminated through peer-reviewed journals for publications.Trial registration numberNCT03546595; Pre-results.
Accounting for health literacy and intervention preferences when reducing unhealthy snacking: protocol for an online randomised controlled trial
Authors: Ayre Julie , Cvejic Erin , Bonner Carissa , Turner Robin M , Walter Stephen D , McCaffery Kirsten J 
Published: May 2019

IntroductionHealth literacy describes the cognitive and social skills that individuals use to access, understand and act on health information. Health literacy interventions typically take the ‘universal precautions approach’ where all consumers are presented with simplified materials. Although this approach can improve knowledge and comprehension, its impact on complex behaviours is less clear. Systematic reviews also suggest that health literacy interventions underuse volitional strategies (such as planning) that play an important role in behaviour change. A recent study found volitional strategies may need to be tailored to the participant’s health literacy. The current study aims to replicate these findings in a sample of people who have diabetes and/or are overweight or obese as measured by body mass index, and to investigate the most effective method of allocating an action plan to a participant to reduce unhealthy snacking.Methods and analysisWe plan to recruit approximately 2400 participants at baseline. Participants will receive one of two alternative online action plans intended to reduce unhealthy snacking (‘standard’ action plan or ‘literacy-sensitive’ action plan). Participants will be randomised to a method of allocation to an action plan: (1) random allocation; (2) allocation by health literacy screening tool or (3) allocation by participant selection. Primary outcome is self-reported serves of unhealthy snacks during the previous month. Multiple linear regression will evaluate the impact of health literacy on intervention effectiveness. The analysis will also identify independent contributions of each action plan, method of allocation, health literacy and participant selections on unhealthy snacking at 4-week follow-up.Ethics and disseminationThis study was approved by the University of Sydney Human Research Ethics Committee (2017/793). Findings will be disseminated through peer-reviewed international journals, conferences and updates with collaborating public health bodies (Diabetes New South Wales (NSW) & Australian Capital Territory (ACT), and Western Sydney Local Health District).Trial registration numberACTRN12618001409268; Pre-results.
Life course analysis on income and incident AMI: a Danish register-based cohort study
Authors: Kriegbaum Margit , Hougaard Charlotte Ørsted , Andersen Ingelise , Brønnum-Hansen Henrik , Lund Rikke 
Published: May 2019

BackgroundSocial inequality in ischaemic heart disease has been related to socioeconomic position in childhood, early adulthood and late adulthood. However, the impact of relative level of accumulated income periods across adult life course and the potential gender and age differences have not been investigated. The aim was to investigate the association between relative level of accumulated income across the life course and acute myocardial infarction (AMI) from age 60+ years and to study if the associations differ by gender and in different age groups (30–39 years, 40–49 years and 50–59 years).MethodsAll Danes born 1935–1954 (N=1 235 139) were followed up in registers for incident AMI (42 669 cases). The accumulated proportional deviation from median equivalised income (APDMEI) for each gender/age/calendar year strata was constructed and divided in quartiles. The associations were analysed by means of Cox’s proportional hazard models.ResultsAmong men, those in the lowest APDMEI quartile had an HR 1.40 (1.35–1.45) of AMI compared with the highest quartile. Those in the second and third highest quartiles had HR of 1.24 (1.20–1.28) and 1.14 (1.10–1.18), respectively. Among women, the lowest quartile had an HR of 1.78 (1.69–1.88), the second 1.45 (1.37–1.53) and the third 1.19 (1.13–1.26). The social gradient was similar across the different age groups.ConclusionThe risk of AMI increased with lower levels of relative accumulated income across the life course. While men generally had a higher risk of AMI, the social gradient was steeper in women. There was no indication of a specific sensitive age period for exposure to relative level of accumulated income.
Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtle
Authors: Hawrysh Peter John , Buck Leslie Thomas 
Published: May 2019

The western painted turtle ( Chrysemys picta bellii) has the unique ability of surviving several months in the absence of oxygen, which is termed anoxia. One major protective strategy that the turtle employs during anoxia is a reduction in neuronal electrical activity, which may result from a natural reduction in reactive oxygen species (ROS). We previously linked a reduction in ROS levels to an increase in γ-amino butyric acid (GABA) receptor currents. The purpose of this study is to understand how fast-spiking, GABA-releasing neurons respond to reductions in ROS and how this affects GABA release. Using a fluorescence-coupled enzymatic microplate assay for GABA, we found that anoxia, the ROS scavenger N-(2-mercaptopriopionyl)glycine (MPG), or the mitochondria-specific ROS scavenger MitoTEMPO resulted in a 2.5-, 2.0-, and 2.5-fold increase in extracellular GABA concentration, respectively. This phenomenon could be blocked with TTX, indicating that it is activity dependent. Using whole cell patch-clamping techniques, we found that fast-spiking, burst-firing GABAergic turtle neurons increase the duration and number of action potentials per burst by 26% and 42%, respectively, in response to ROS scavenging via MPG. These results suggest that the reduction in mitochondrially produced ROS that occurs during anoxia leads to increased GABA release, which promotes postsynaptic inhibitory activity through activation of GABA receptors.NEW & NOTEWORTHY This is a novel study examining the response of cerebral cortical stellate interneurons to anoxia and mitochondrial reactive oxygen species (ROS) scavenging with MitoTEMPO. Under both conditions burst firing increases in these cells, and we show that extracellular GABA release increases in the presence of the ROS scavenger. We conclude that in the anoxia-tolerant painted turtle brain, a decrease in ROS levels is an important low oxygen signal.
A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma
Authors: McMichael Elizabeth L. , Benner Brooke , Atwal Lakhvir S. , Courtney Nicholas B. , Mo Xiaokui , Davis Melanie E. , Campbell Amanda R. , Duggan Megan C. , Williams Kallan , Martin Kyle , Levine Kala , Olaverria Salavaggione Gonzalo N. , Noel Tiffany , Ganju Akaansha , Uppati Sarvani , Paul Bonnie , Olencki Thomas , Teknos Theodoros N. , Savvides Panos , Tridandapani Susheela , Byrd John C. , Caligiuri Michael A. , Liu Stephen V. , Carson William E. 
Published: May 2019

AbstractPurpose:mAbs including cetuximab can induce antibody-dependent cellular cytotoxicity (ADCC) and cytokine production mediated via innate immune cells with the ability to recognize mAb-coated tumors. Preclinical modeling has shown that costimulation of natural killer (NK) cells via the Fc receptor and the IL12 receptor promotes NK-cell–mediated ADCC and production of cytokines.Patients and Methods:This phase I/II trial evaluated the combination of cetuximab with IL12 for the treatment of EGFR-expressing head and neck cancer. Treatment consisted of cetuximab 500 mg/m2 i.v. every 2 weeks with either 0.2 mcg/kg or 0.3 mcg/kg IL12 s.c. on days 2 and 5 of the 2-week cycle, beginning with cycle 2. Correlative studies from blood draws obtained prior to treatment and during therapy included measurement of ADCC, serum cytokine, and chemokine analysis, determination of NK cell FcγRIIIa polymorphisms, and an analysis of myeloid-derived suppressor cell (MDSC) frequency in peripheral blood.Results:The combination of cetuximab and IL12 was well tolerated. No clinical responses were observed, however, 48% of patients exhibited prolonged progression-free survival (PFS; average of 6.5 months). Compared with patients that did not exhibit clinical benefit, patients with PFS &gt;100 days exhibited increased ADCC as therapy continued compared with baseline, greater production of IFNγ, IP-10, and TNFα at the beginning of cycle 8 compared with baseline values and had a predominance of monocytic MDSCs versus granulocytic MDSCs prior to therapy.Conclusions:Further investigation of IL12 as an immunomodulatory agent in combination with cetuximab in head and neck squamous cell carcinoma is warranted.
Voxel Forecast for Precision Oncology: Predicting Spatially Variant and Multiscale Cancer Therapy Response on Longitudinal Quantitative Molecular Imaging
Authors: Bowen Stephen R. , Hippe Daniel S. , Chaovalitwongse W. Art , Duan Chunyan , Thammasorn Phawis , Liu Xiao , Miyaoka Robert S. , Vesselle Hubert J. , Kinahan Paul E. , Rengan Ramesh , Zeng Jing 
Published: May 2019

Abstract

Purpose:
Prediction of spatially variant response to cancer therapies can inform risk-adaptive management within precision oncology. We developed the “Voxel Forecast” multiscale regression framework for predicting spatially variant tumor response to chemoradiotherapy on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging.

Experimental Design:
Twenty-five patients with locally advanced non–small cell lung cancer, enrolled on the FLARE-RT phase II trial (NCT02773238), underwent FDG PET/CT imaging prior to (PETpre) and during week 3 (PETmid) of concurrent chemoradiotherapy. Voxel Forecast was designed to predict tumor voxel standardized uptake value (SUV) on PETmid from baseline patient-level and voxel-level covariates using a custom generalized least squares (GLS) algorithm. Matérn covariance matrices were fit to patient- specific empirical variograms of distance-dependent intervoxel correlation. Regression coefficients from variogram-based weights and corresponding standard errors were estimated using the jackknife technique. The framework was validated using statistical simulations of known spatially variant tumor response. Mean absolute prediction errors (MAEs) of Voxel Forecast models were calculated under leave-one-patient-out cross-validation.

Results:
Patient-level forecasts resulted in tumor voxel SUV MAE on PETmid of 1.5 g/mL while combined patient- and voxel-level forecasts achieved lower MAE of 1.0 g/mL (P &lt; 0.0001). PETpre voxel SUV was the most important predictor of PETmid voxel SUV. Patients with a greater percentage of under-responding tumor voxels were classified as PETmid nonresponders (P = 0.030) with worse overall survival prognosis (P &lt; 0.001).

Conclusions:
Voxel Forecast multiscale regression provides a statistical framework to predict voxel-wise response patterns during therapy. Voxel Forecast can be extended to predict spatially variant response on multimodal quantitative imaging and may eventually guide optimized spatial–temporal dose distributions for precision cancer therapy.
Olfactory recognition of snake cues by fawn-footed mosaic-tailed rats Melomys cervinipes
Authors: Paulling Kelsey , Wilson David , Rymer Tasmin L. 
Published: May 2019

Abstract
Rodents rely on their sensitive olfactory systems to detect and respond to predators. We investigated the ability of a native Australian rodent, the fawn-footed mosaic-tailed rat Melomys cervinipes, to detect, recognise, and discriminate between two species of native snakes. We used snake sheds from a sympatric venomous red-bellied black snake Pseudechis porphyriacus and a non-sympatric non-venomous Stimson’s python Antaresia stimsoni. 20 mosaic-tailed rats each experienced three olfactory tests using a Y-maze. Rats were first exposed to one snake shed against a paper control, and then exposed to the other snake shed against a paper control. Which rat experienced which shed first was allocated randomly. Mosaic-tailed rats were then exposed to both sheds simultaneously. Rats could detect the snake sheds, spending longer investigating, and making more visits to, the sheds than the paper control. They also recognised the sheds as potentially dangerous, reducing their total investigation over time, but increasing their frequency of visits. However, rats did not discriminate between sheds, suggesting a general strategy for assessing the identity of reptilian predators.
Food Production or Food Distribution: The Key to Global Food Security?
Authors: Kick Edward L. , Tiezzi Francesco , Pena Diego Castedo 
Published: May 2019

Abstract
Major world agencies have identified a serious contemporary food insecurity problem, and sound even louder alarms that by the year 2050 around one billion people will be “food insecure.” The solution proposed by the World Bank in a 2012 Report is that the world grow significantly more food. Eyes certainly are on the us to remediate this problem by growing more livestock. Is “more food” the answer? This study uses World Bank data and path/structural equation modeling to determine the veracity of this position versus another. It is counter argued that food distribution and waste prevent food from reaching substantial segments of the world’s population. That is, the poor and dependent are unable to gain access to food that is privateered by governance systems that permit rulers and the wealthy to access food, and set food prices at unreachable levels for the poorest of the poor and, sometimes, even the middle class. Further, wages are set below the level needed to purchase basic food stuffs. The reaction has been food riots in countries ranging from Venezuela to the Middle East countries such as Lebanon, Jordan, Libya, and Egypt, among others.
Decolonizing Food Systems: Food Sovereignty, Indigenous Revitalization, and Agroecology as Counter-Hegemonic Movements
Authors: Figueroa-Helland Leonardo , Thomas Cassidy , Aguilera Abigail Pérez 
Published: May 2019

Abstract
We employ an intersection of critical approaches to examine the global food system crisis and its alternatives. We examine counterhegemonic movements and organizations advancing programs of constructive resistance and decolonization based on food sovereignty, indigenous revitalization and agroecology. Food system alternatives rooted in intersectional critiques of the world-system open spaces for materially-grounded, commons-based socioecological relations that make just, sustainable, and equitable worlds possible beyond a civilization in crisis.
Private Health Care Expenditure and Child Health Outcomes in the World’s Poorest Countries
Authors: Yasin Jehad , Gani Azmat 
Published: May 2019

Abstract
Empirical studies investigating the direct effects of private health expenditure on child health outcomes for the world’s poorest countries are rare. This study attempts to fill this gap. The methodology includes empirical estimations of cross-country annual data for the period 1995-2010 for several low-income countries. The results obtained through fixed-effects estimation provide strong evidence that private health care spending has the expected negative and statistically significant effect on neonatal, infant and under-five mortality rates. The findings also reveal that other than private health care spending, income, nutrition, urbanization, family size, immunization against measles, and access to an improved water supply and sanitation as other strong determinants of neonatal, infant and under-five mortality rates. Some policy implications are drawn.
Before There Were Charismatics
Authors: Moudry Susan Lyn 
Published: May 2019

Abstract
Pentecostalism came to Pittsburgh prior to the 1967 Catholic Charismatic Movement through the life and teaching of Charles Hamilton Pridgeon. Although Pridgeon commonly appears in texts about Pentecostalism as a footnote to the larger story, he offers an interesting case study. His journey into the pentecostal ranks illustrates diversity among early pentecostal leaders both theologically and socially. Pridgeon, then, offers a lens for viewing Pittsburgh’s early encounter with Pentecostalism, while also demonstrating motives for such groups as the Assemblies of God who defined theological boundaries early in the twentieth century in response to his work.
The Reşwan Kurds and Ottoman Tribal Settlement in Syria, 1683-1741
Authors: Winter Stefan 
Published: May 2019

Abstract
The Reşwan were one of the most important tribal confederations in the Ottoman Empire in the eighteenth century. Yet their history remains almost completely ignored, while the few contemporary authors who refer them almost invariably fail to mention that they were Kurds. This article seeks to retrace the history of the Reşwan confederation and particularly their place in the Ottoman imperial tribal settlement (iskan) scheme of the eighteenth century. Drawing on both Ottoman chancery documents and local şeriat archives, it seeks to show that the Reşwan enjoyed relatively good relations with the Ottoman authorities and a high degree of integration with other groups in northern Syria and Mesopotamia, with individual members attaining high office in the region. While the Reşwan name has virtually disappeared, members of the confederation in Turkey today still trace their origins to the Syrian settlement initiative.
L’economia islamica: alternativa apparente o reale?
Authors: Cattelan Valentino 
Published: May 2019

Abstract
This article deals with the nature of Islamic economics as a scientific paradigm which claims to be alternative to conventional economic thinking.
To critically evaluate this claim, the work investigates the peculiar religious and moral principles that shape the idea of social justice in Islam. Subsequently, it outlines how Islamic economics derives from these principles a specific conceptualization of property rights and commercial relations that embraces parameters of (1) primacy of real economy; (2) transactional equilibrium; (3) and profit- and risk-sharing.
By endorsing the conceptual autonomy of Islamic economics from conventional capitalism, the article also refers to the current emergence of the Islamic financial market at a global stage, and the possible implications for a plural financial system in the future.
Les sources de Victor Hugo par rapport à la Perse
Authors: Tavakoli Hélia 
Published: May 2019

AbstractEn tant que le chef de file du romantisme, Victor Hugo a énormément influencé le XIXe siècle par ses idées et sa philosophie. Comment pouvons-nous étudier l’Orient et ne pas parler des Orientales ? C’est en lisant Les Orientales de Hugo que nous avons aperçu à notre grand étonnement, en tête de ses poèmes, les épigraphes de poètes persans. Cet article illustre une étude sur Victor Hugo et la Perse et essaie de répondre aux questions suivantes : Que savait Hugo de la Perse ? Comment pouvait-il connaitre les poètes persans ? Qui étaient ses poètes persans préférés ? Ses informations sur la Perse étaient-elles seulement littéraires ou étaient-elles également inspirées par l’histoire et la religion de ce pays dans lequel n’avait jamais voyagé ? S’il connaissait la Perse ancienne, avait-il eu des idées sur Zoroastre et Mani ?