bluuebunny/crossref_metadata_2025_split huggingface dataset:
Previewing a face in the periphery reduces the fN170: Combined EEG and eye-tracking suggests two stages of trans-saccadic predictive processes
Authors: Huber-Huber Christoph , Buonocore Antimo , Hickey Clayton , Melcher David 
Published: November 2018

AbstractThe world appears stable despite saccadic eye-movements. One possible explanation for this phenomenon is that the visual system predicts upcoming input across saccadic eye-movements, based on peripheral preview of the saccadic target. We tested this idea using concurrent electroencephalography (EEG) and eye-tracking. Participants made cued saccades to peripheral upright or inverted face stimuli that could change (invalid preview) or keep their orientation (valid preview) across the saccade. Experiment 1 demonstrated better discrimination performance and a reduced fixation-locked N170 (fN170) with valid than with invalid preview demonstrating integration of pre- and post-saccadic information. Moreover, the early fixation-locked EEG showed a preview face inversion effect suggesting that we perceive pre-saccadic input up to about 170 ms post fixation-onset, at least for face orientation. Experiment 2 replicated Experiment 1 and manipulated the proportion of valid and invalid trials (mostly valid versus mostly invalid, 66.6% to 33.3%) to test whether the preview effect reflected active expectations. A whole-scalp Bayes factor analysis provided evidence for no influence of proportion on the fN170 preview effect. Instead, before the saccade the preview face orientation effect declined earlier in the mostly invalid than in the mostly valid block suggesting some form of pre-saccadic expectations. We conclude that visual stability is achieved by two trans-saccadic integration processes: pre-saccadic prediction, reflected in the pre-saccadic proportion modulation, and early post-saccadic change-detection reflected in the fN170 preview effect.
What’s in Your Gamma? Activation of The Ventral Fronto-Parietal Attentional Network in Response to Distracting Sounds
Authors: ElShafei Hesham A. , Fornoni Lesly , Masson Rémy , Bertrand Olivier , Bidet-Caulet Aurélie 
Published: November 2018

ABSTRACTAuditory attention operates through top-down (TD) and bottom-up (BU) mechanisms that are supported by dorsal and ventral brain networks, respectively, with the main overlap in the lateral prefrontal cortex (lPFC). A good TD/BU balance is essential to be both task-efficient and aware of our environment, yet it is rarely investigated. Oscillatory activity is a novel method to probe the attentional dynamics with evidence that gamma activity (>30Hz) could signal BU processing and thus would be a good candidate to support the activation of the ventral BU network. MEG data were collected from 21 young adults performing the Competitive Attention Task which enables simultaneous investigation of BU and TD attentional mechanisms. Distracting sounds elicited an increase in gamma activity in regions of the BU ventral network. TD attention modulated these gamma responses in regions of the inhibitory cognitive control system: the medial prefrontal and anterior cingulate cortices. Finally, distracting-sound-induced gamma activity was synchronous between the auditory cortices and several distant brain regions, notably the lPFC. We provide novel insight into the role of gamma activity (1) in supporting the activation of the BU ventral network, and (2) in subtending the TD/BU attention balance in the prefrontal cortex.
DNA Extraction Method Optimized for Nontuberculous Mycobacteria Long-Read Whole Genome Sequencing
Authors: Bouso Jennifer M. , Planet Paul J. 
Published: November 2018

AbstractNontuberculous mycobacteria (NTM) are a major cause of pulmonary and systemic disease in at-risk populations. Gaps in knowledge about transmission patterns, evolution, and pathogenicity during infection have prompted a recent surge in genomic NTM research. Increased availability and affordability of whole genome sequencing (WGS) techniques, including the advent of Oxford Nanopore Technologies, provide new opportunities to sequence complete NTM genomes at a fraction of the previous cost. However, extracting large quantities of pure genomic DNA is particularly challenging with NTM due to their slow growth and recalcitrant cell wall. Here we report a DNA extraction protocol that is optimized for long-read WGS of NTM, yielding large quantities of highly pure DNA. Our refined method was compared to 6 other methods with variations in timing of mechanical and enzymatic digestion, quantity of matrix material, and reagents used in extraction and precipitation. We also demonstrate the ability of our optimized protocol to produce sufficient DNA to yield near-complete NTM genome assemblies using Oxford Nanopore Technologies long-read sequencing.
Noncontractile tissue forces mask muscle fiber forces underlying muscle spindle Ia afferent firing rates in stretch of relaxed rat muscle
Authors: Blum Kyle P. , Nardelli Paul , Cope Timothy C. , Ting Lena H. 
Published: November 2018

AbstractStretches of relaxed cat and rat muscle elicit similar history-dependent muscle spindle Ia firing rates that resemble history-dependent forces seen in single activated muscle fibers (Nichols and Cope, 2004). During stretch of relaxed cat muscle, whole musculotendon forces exhibit history-dependence that mirror history-dependent muscle spindle firing rates, where both muscle force and muscle spindle firing rates are elevated in the first stretch in a series of stretch-shorten cycles (Blum et al., 2017). By contrast, rat musculotendon are only mildly history-dependent and do not mirror history-dependent muscle spindle firing rates in the same way (Haftel et al., 2004). We hypothesized that history-dependent muscle spindle firing rates elicited in stretch of relaxed rat muscle would mirror history-dependent muscle fiber forces, which are masked by noncontractile tissue at the level of whole musculotendon force. We removed noncontractile tissue force contributions from the recorded musculotendon force using an exponentially-elastic tissue model. We then show that the remaining estimated muscle fiber force resembles history-dependent muscle spindle firing rates recorded simultaneously. These forces also resemble history-dependent forces recorded in stretch of single activated fibers and attributed to muscle cross-bridge mechanisms (Campbell and Moss, 2000). Our results suggest that history-dependent muscle spindle firing in both rats and cats arise from stretch of cross-bridges in muscle fibers.
Tcf4 encodescortical differentiation during development
Authors: Mesman Simone , Bakker Reinier , Smidt Marten P. 
Published: November 2018

AbstractTcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in humans, however, the mechanisms behind its role in disease development is still elusive. In the present study, we provide evidence that Tcf4 has a critical function in the differentiation of cortical regions during development.We show that Tcf4 is present throughout the developing brain at the peak of neurogenesis. Deletion of Tcf4 results in mis-specification of the cortical layers, malformation of the corpus callosum and hypoplasia of the hippocampus. RNA-sequencing on E14.5 cortex material shows that Tcf4 functions as a transcriptional activator and loss of Tcf4 results in downregulation of genes linked to the emergence of other neurodevelopmental disorders. Taken together, we show that neurogenesis and differentiation are severely affected in Tcf4 mutants, phenocopying morphological brain defects detected in PTHS patients. The presented data identifies new leads to understand the mechanism of human brain defects and will assist in genetic counseling programs.
Subcellular orchestration of alpha-synuclein variants in Parkinson’s disease brains revealed by 3D multicolor STED microscopy
Authors: Moors Tim E. , Maat Christina A. , Niedieker Daniel , Mona Daniel , Petersen Dennis , Timmermans-Huisman Evelien , Kole Jeroen , El-Mashtoly Samir F. , Spycher Liz , Zago Wagner , Barbour Robin , Mundigl Olaf , Kaluza Klaus , Huber Sylwia , Hug Melanie N. , Kremer Thomas , Ritter Mirko , Dziadek Sebastian , Geurts Jeroen J.G. , Gerwert Klaus , Britschgi Markus , van de Berg Wilma D.J. 
Published: November 2018

AbstractPost-translational modifications of alpha-synuclein (aSyn), particularly phosphorylation at Serine 129 (Ser129-p) and truncation of its C-terminus (CTT), have been implicated in Parkinson’s disease (PD) pathology. To gain more insight in the relevance of Ser129-p and CTT aSyn under physiological and pathological conditions, we investigated their subcellular distribution patterns in normal aged and PD brains using highly-selective antibodies in combination with 3D multicolor STED microscopy. We show that CTT aSyn localizes in mitochondria in PD patients and controls, whereas the organization of Ser129-p in a cytoplasmic network is strongly associated with pathology. Nigral Lewy bodies show an onion skin-like architecture, with a structured framework of Ser129-p aSyn and neurofilaments encapsulating CTT aSyn in their core, which displayed high content of proteins and lipids by label-free CARS microscopy. The subcellular phenotypes of antibody-labeled pathology identified in this study provide evidence for a crucial role of Ser129-p aSyn in Lewy body formation.
Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models
Authors: Liedekerke Paul Van , Neitsch Johannes , Johann Tim , Warmt Enrico , Valverde Ismael Gonzales , Höhme Stefan , Grosser Steffen , Käs Josef , Drasdo Dirk 
Published: November 2018

AbstractMathematical models are increasingly designed to guide experiments in biology, biotechnology, as well as to assist in medical decision making. They are in particular important to understand emergent collective cell behavior. For this purpose, the models, despite still abstractions of reality, need to be quantitative in all aspects relevant for the question of interest. The focus in this paper is to study the regeneration of liver after drug-induced depletion of hepatocytes, in which surviving dividing and migrating hepatocytes must squeeze through a blood vessel network to fill the emerged lesions. Here, the cells’ response to mechanical stress might significantly impact on the regeneration process. We present a 3D high-resolution cell-based model integrating information from measurements in order to obtain a refined quantitative understanding of the cell-biomechanical impact on the closure of drug-induced lesions in liver. Our model represents each cell individually, constructed as a physically scalable network of viscoelastic elements, capable of mimicking realistic cell deformation and supplying information at subcellular scales. The cells have the capability to migrate, grow and divide, and infer the nature of their mechanical elements and their parameters from comparisons with optical stretcher experiments. Due to triangulation of the cell surface, interactions of cells with arbitrarily shaped (triangulated) structures such as blood vessels can be captured naturally. Comparing our simulations with those of so-called center-based models, in which cells have a rigid shape and forces are exerted between cell centers, we find that the migration forces a cell needs to exert on its environment to close a tissue lesion, is much smaller than predicted by center-based models. This effect is expected to be even more present in chronic liver disease, where tissue stiffens and excess collagen narrows pores for cells to squeeze through.
Conflict-resolution algorithms for RPAS in non-segregated airspace
Authors: Pérez-Castán Javier A. , Gómez Comendador Fernando , Rodríguez-Sanz Álvaro , Arnaldo Valdés Rosa M. , Torrecilla Jaime 
Published: November 2018

Purpose
The purpose of this paper is to focus on the development of conflict-resolution algorithms between Remotely Piloted Aircraft System (RPAS) and conventional aircraft. The goal of the conflict-resolution algorithm is to estimate the minimum protection distance (MPD) which is required to avoid a potential conflict.

Design/methodology/approach
The conflict-resolution algorithms calculate the last location at which an RPAS must start climbing to avoid a separation minima infringement. The RPAS maneuvers to prevent the conventional aircraft based on the kinematic equations. The approach selects two parameters to model the conflict-geometry: the path-intersection angle and the Rate of Climb (ROCD).

Findings
Results confirmed that the aircraft pair flying in opposition was the worst scenario because the MPD reached its maximum value. The best value of the MPD is about 12 Nautical Miles to ensure a safe resolution of a potential conflict. Besides, variations of the ROCD concluded that the relation between the ROCD and the MPD is not proportional.

Research limitations/implications
The primary limitation is that the conflict-resolution algorithms are designed in a theoretical framework without bearing in mind other factors such as communications, navigation capacity, wind and pilot errors among others. Further work should introduce these concepts to determine how the MPD varies and affects air traffic safety. Moreover, the relation between an ROCD requirement and the MPD will have an impact on regulations.

Practical implications
The non-linear relation between the MPD and the ROCD could be the pillar to define a standardized MPD in the future for RPAS systematic integration. To accomplish this standard, RPAS could have to fulfil a requirement of minimum ROCD until a specified flight level.

Originality/value
This paper is the first approach to quantify the Minimum Protection Distance between RPAS and conventional aircraft, and it can serve the aeronautical community to define new navigation requirements for RPAS.
Role of logistics strategy, coordination and customer service commitment on Chinese manufacturing firm competitiveness
Authors: Spillan John E. , Mintu-Wimsatt Alma , Kara Ali 
Published: November 2018

Purpose
The purpose of this paper is to assess the robustness of the three (Bowersox and Daugherty, 1987) dimensions (process, market and information strategies) of logistics strategy in a Chinese manufacturing environment. In addition, the impact of the three dimensions, coordination and customer service on the organizational competitiveness of Chinese manufacturers firms is explored.

Design/methodology/approach
The authors conducted an online survey hosted at Sojump.com and disseminated to members of a manufacturing trade association. A total of 513 completed responses were generated. Confirmatory factor analysis (CFA) and structural equation model (SEM) were used to test the hypothesized relationships in the conceptual model.

Findings
The findings suggest that the three dimensions of the Bowersox and Daugherty (1987) were relevant to the Chinese manufacturing environment. The authors also found that the overall logistics strategy measured by the three dimensions as well as coordination and customer service effectiveness positively influenced Chinese manufacturing firms’ competiveness.

Research limitations/implications
Further research into logistics and supply chain management may benefit from expanding the understanding to include antecedents and moderating factors (e.g. competition, market turbulence and differences in business environment) into the model. Future studies on cross-cultural logistics/supply chain management logistics may benefit from the application of strategy-structure-process (SSP) approaches similar to those discussed in this manuscript.

Practical implications
This study attempted to provide a robust conceptual framework to increase the understanding of the role of logistics/supply chain management strategy and provide insights to managers seeking to improve firm competitiveness. An essential implication of the conceptual model presented in this manuscript is the dynamics of logistics strategy as a competitive tool.

Social implications
The findings provide an understanding of how business and manufacturing are operating in various locations in China with opportunities for employment and socio-economic gain among the population of these geographic locations. Having employment can provide a better quality of life and assist the community in developing its opportunities for other groups.

Originality/value
As the current Chinese administration seeks to achieve its goal of generating higher value-added production through its “Made in China 2025” initiative, the results the authors represent are quite timely and insightful. Examining manufacturing firms’ logistics strategies (i.e., OLS), coordination and customer service could provide state planners (SOEs) and/or privately owned Chinese manufacturers insights on how to move closer towards their aforementioned goal and achieve global competitiveness.
The principal contradiction and its evolution in the new era of the socialism society with Chinese characteristics
Authors: Wei Xinghua 
Published: November 2018

Purpose
Marx suggested that it is infeasible and wrong to arrange the economic categories according to the order by which they have worked in history. Their order is determined by their interrelationship in the modern bourgeois society, which is in contrast to their natural sequence or that which is in accordance with the course of history. Sometimes, a logical sequence is precisely opposite to the historical sequence. There are many efforts to be done in the study of China’s economic and social issues with Marxist logical and historical methods. The paper aims to discuss these issues.

Design/methodology/approach
When reading Das Kapital, we can clearly see the historical materialism methods. Another method of Marxist political economics is the scientific abstract method.

Findings
This is based on the new development idea to carry out scientific and technological innovation and change the focus of development from quantity to quality. With regard to the supply side structural reform as the main focus, people’s ever-growing demand for a better life can be satisfied and the higher level dynamic supply–demand balance can be kept.

Originality/value
In fact, measures to remedy unbalanced and inadequate development of the social principal contradiction have been plainly indicated in the report delivered at the 19th National Congress of the Communist Party of China. This is based on the new development idea to carry out scientific and technological innovation and change the focus of development from quantity to quality.
A welfare economics analysis of China’s industrial layout restructuring
Authors: Fuxiang Wu , Yue Cai 
Published: November 2018

Purpose
At present, China’s industrial spatial layout faces the predicament of over-agglomeration of Eastern China industries and the near disintegration of industrial structure in the central and western regions. The paper aims to discuss this issue.

Design/methodology/approach
Based on the perspective of differentiated inter-regional labor mobility, this paper constructed a model framework of quadratic sub-utility quasi-linear preference utility function, and conducted model deduction and numerical simulation on causal factors of this spatial imbalance along the two dimensions of individual and regional welfare.

Findings
The study finds that in the long run, industrial spatial layout imposes a certain threshold limit on the portfolio proportion of differentiated labor. The dilemma of China’s industrial spatial layout is attributable to the deviation of the market’s optimal agglomeration from the social optimal agglomeration, and to the disfunction of Eastern China’s role as an intermediary between the global and the domestic value chain.

Originality/value
To resolve this predicament of industrial layout, the unitary welfare compensation based on fiscal transfer payment has to be switched to a more comprehensive approach giving consideration to industrial rebalancing.
Validating a model of strategic leadership practices for Malaysian vocational college educational leaders
Authors: Mohd Ali Hairuddin bin , Zulkipli Inas Binti 
Published: November 2018

Purpose
The purpose of this study is to conceptualize, validate and confirm a structural equation modeling (SEM) hypothesized model of strategic leadership practices of Malaysian vocational college educational leaders.

Design/methodology/approach
The study used a quantitative survey approach. The data were collected from 500 educational leaders of 65 Malaysian vocational colleges throughout Malaysia using a five-point strategic leadership scale. The gender composition of the sample was almost equivalent. The study embarked on descriptive statistics, confirmatory factor analysis and full-fledged SEM for the data analyses.

Findings
The findings revealed that the Malaysian vocational college educational leaders had high tendency and inclination of practicing strategic leadership at their workplace. Besides, there was also evidence that the educational leaders of the Malaysian vocational college exhibited high levels or degree of strategic leadership practices. The responses to the survey items were consistent with seven distinct practices of strategic leadership such as strategic orientation, strategic alignment, strategic intervention, restlessness, absorptive capacity, adaptive capacity and leadership wisdom. The use of SEM procedures had confirmed that the hypothesized model of strategic leadership practices for Malaysian vocational college educational leaders was empirically valid and reliable.

Practical implications
The findings highlighted the importance of planning and development of a specific-context training program for Malaysian vocational college educational leaders in strategic leadership. The training was considered fundamental in pursuit of effective leadership and positive institutional outcomes for such colleges in Malaysia.

Originality/value
The study had successfully formulated, tested and validated a model of strategic leadership practices for Malaysian vocational college educational leaders. The model was believed to be the first of its kind in the Malaysian vocational education context.
Household mortgage demand: a study of the UK, Australia and Japan
Authors: Naoi Michio , Tiwari Piyush , Moriizumi Yoko , Yukutake Norifumi , Hutchison Norman , Koblyakova Alla , Rao Jyoti 
Published: November 2018

PurposeHomeownership has been the main focus of housing policies in most countries. Typical means that households use to achieve homeownership is to take out a loan and supplement this with accumulated wealth for a downpayment. This paper aims to analyze the mortgage demand behavior of households in the UK, Australia and Japan.Design/methodology/approachUsing three panel data sets, HILDA for Australia, KHPS for Japan and USS for the UK, the paper estimates three equations using ordinary least squares: mortgage demand function, housing demand function and initial loan to value ratio function.FindingsThough homeownership is a preferred tenure and the mortgages are “recourse” loans, housing markets in these three countries operate in different mortgage market institutional structures. Results indicate that income elasticity of mortgage demand differ despite income elasticity of housing demand being similar. Different mortgage institutions in countries that pose constraints for borrowers also determine mortgage demand. Other factors such as demography and economic conditions have also played an important role in determining mortgage and housing demand.Originality/valueThe paper is first, to the authors’ knowledge, that explores the role of institutions in mortgage demand in a comparative framework for the UK, Japan and Australia.