bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Future Projections of Precipitation Characteristics around Japan in Early Summer Combining GPM DPR Observation and CMIP5 Large-Scale Environments
Authors: Yokoyama Chie , Takayabu Yukari N. , Arakawa Osamu , Ose Tomoaki 
Published: June 2019

AbstractThis study estimates future changes in the early summer precipitation characteristics around Japan using changes in the large-scale environment, by combining Global Precipitation Measurement precipitation radar observations and phase 5 of the Coupled Models Intercomparison Project climate model large-scale projections. Analyzing satellite-based data, we first relate precipitation in three types of rain events (small, organized, and midlatitude), which are identified via their characteristics, to the large-scale environment. Two environmental fields are chosen to determine the large-scale conditions of the precipitation: the sea surface temperature and the midlevel large-scale vertical velocity. The former is related to the lower-tropospheric thermal instability, while the latter affects precipitation via moistening/drying of the midtroposphere. Consequently, favorable conditions differ between the three types in terms of these two environmental fields. Using these precipitation–environment relationships, we then reconstruct the precipitation distributions for each type with reference to the two environmental indices in climate models for the present and future climates. Future changes in the reconstructed precipitation are found to vary widely between the three types in association with the large-scale environment. In more than 90% of models, the region affected by organized-type precipitation will expand northward, leading to a substantial increase in this type of precipitation near Japan along the Sea of Japan, and in northern and eastern Japan on the Pacific side, where its present amount is relatively small. This result suggests an elevated risk of heavy rainfall in those regions because the maximum precipitation intensity is more intense in organized-type precipitation than in the other two types.
The Impact of Large-Scale Orography on Northern Hemisphere Winter Synoptic Temperature Variability
Authors: Lutsko Nicholas J. , Baldwin Jane Wilson , Cronin Timothy W. 
Published: June 2019

Abstract
The impact of large-scale orography on wintertime near-surface (850 hPa) temperature variability on daily and synoptic time scales (from days to weeks) in the Northern Hemisphere is investigated. Using a combination of theory, idealized modeling work, and simulations with a comprehensive climate model, it is shown that large-scale orography reduces upstream temperature gradients, in turn reducing upstream temperature variability, and enhances downstream temperature gradients, enhancing downstream temperature variability. Hence, the presence of the Rockies on the western edge of the North American continent increases temperature gradients over North America and, consequently, increases North American temperature variability. By contrast, the presence of the Tibetan Plateau and the Himalayas on the eastern edge of the Eurasian continent damps temperature variability over most of Eurasia. However, Tibet and the Himalayas also interfere with the downstream development of storms in the North Pacific storm track, and thus damp temperature variability over North America, by approximately as much as the Rockies enhance it. Large-scale orography is also shown to impact the skewness of downstream temperature distributions, as temperatures to the north of the enhanced temperature gradients are more positively skewed while temperatures to the south are more negatively skewed. This effect is most clearly seen in the northwest Pacific, off the east coast of Japan.
Do We Really Need More Stages? Comparing the Effects of Likelihood Alarm Systems and Binary Alarm Systems
Authors: Zirk Anna , Wiczorek Rebecca , Manzey Dietrich 
Published: June 2019

Objective This research investigates the potential behavioral and performance benefits of a four-stage likelihood alarm system (4-LAS) contrasting a 3-LAS, a binary alarm system with a liberal threshold (lib-BAS), and a BAS with a conservative threshold (con-BAS). Background Prior research has shown performance benefits of 3-LASs over conventional lib-BASs due to more distinct response strategies and better discriminating true from false alerts. This effect might be further enhanced using 4-LASs. However, the increase in stages could cause users to reduce cognitive complexity by responding in the same way to the two lower and the two higher stages, thus treating the 4-LAS like a con-BAS. Method All systems were compared using a dual-task paradigm. Response strategies, number of joint human machine (JHM) false alarms (FAs), misses, and sensitivity were regarded. Results Compared with the lib-BAS, JHM sensitivity only improved with the 4-LAS and the con-BAS. However, the number of JHM misses was lowest for the con-BAS compared with all other systems. Conclusion JHM sensitivity improvements can be achieved by using a 4-LAS, as well as a con-BAS. However, only the latter one may also reduce the number of JHM misses, which is remarkable considering that BASs with conservative thresholds a priori commit more inbuilt misses than other systems. Application Results suggest implementing conservative BASs in multi-task working environments to improve JHM sensitivity and reduce the number of JHM misses. When refraining from designing systems which are miss prone, 4-LASs represent a suitable compromise.
A controlled clinical trial of preoperative pain neuroscience education for patients about to undergo total knee arthroplasty
Authors: Louw Adriaan , Puentedura Emilio J , Reed Jordan , Zimney Kory , Grimm Derek , Landers Merrill R 
Published: June 2019

Objective: The aim of this study was to determine if a preoperative pain neuroscience education program would result in superior outcomes compared to usual preoperative education for total knee arthroplasty. Design: Controlled clinical trial with alternating allocation. Setting: Community-based hospital. Subjects: Consecutive sample of 120 patients scheduled for total knee arthroplasty. Intervention: Traditional hospital preoperative total knee arthroplasty education program on its own, or with an additional 30-minute group pain neuroscience education session. Main measures: Primary outcomes were measurements at one, three, and six months for pain, function, fear of movement, and pain catastrophization. We also compared opioid usage, healthcare expenses, and patient satisfaction between groups. Results: There were no statistically significant differences in any outcome measures between the two groups over time, except for patient satisfaction. Those in the experimental group had more agreement with statements about “preparation for surgery” ( P = .038), “would do again” ( P = .032), and “met expectations” ( P = .033) compared to those in the control group averaged over the three measurement times. Patients improved in several outcome measures over time regardless of group assignment, with a 34% improvement in pain, 36% improvement in function, 16% improvement in fear of movement, and 23% improvement in pain catastrophization scores. Conclusion: Adding a brief 30-minute pain neuroscience education session to a traditional preoperative total knee arthroplasty education program did not result in any significant improvements, except patient satisfaction.
An integrated cell isolation and purification method for rat dorsal root ganglion neurons
Authors: Shen Huaishuang , Gan Minfeng , Yang Huilin , Zou Jun 
Published: June 2019

Objective Neurobiology studies are increasingly focused on the dorsal root ganglion (DRG), which plays an important role in neuropathic pain. Existing DRG neuron primary culture methods have considerable limitations, including challenging cell isolation and poor cell yield, which cause difficulty in signaling pathway studies. The present study aimed to establish an integrated primary culture method for DRG neurons. Methods DRGs were obtained from fetal rats by microdissection, and then dissociated with trypsin. The dissociated neurons were treated with 5-fluorouracil to promote growth of neurons from the isolated cells. Then, reverse transcription polymerase chain reaction and immunofluorescence assays were used to identify and purify DRG neurons. Results Isolated DRGs were successfully dissociated and showed robust growth as individual DRG neurons in neurobasal medium. Both mRNA and protein assays confirmed that DRG neurons expressed neurofilament-200 and neuron-specific enolase. Conclusions Highly purified, stable DRG neurons could be easily harvested and grown for extended periods by using this integrated cell isolation and purification method, which may help to elucidate the mechanisms underlying neuropathic pain.
Effect of using a home-bed mattress on bystander chest compression during out-of-hospital cardiac arrest
Authors: Ahn Hong Joon , Cho Yongchul , You Yeon Ho , Min Jin Hong , Jeong Won Joon , Ryu Seung , Lee Jin Woong , Cho Sung Uk , Oh Se Kwang , Park Jung Soo , Choi Younhyuk 
Published: June 2019

Background: Bystander cardiopulmonary resuscitation is a key component of life-saving after an out-of-hospital cardiac arrest. In the pre-arrival instructions for out-of-hospital cardiac arrest, it is recommended that the patient be laid on a flat floor. However, the most common reason for not performing cardiopulmonary resuscitation is that the bystander could not move the patient. Objectives: This study aim to investigate the effects of using a home-bed mattress on the quality of chest compression. Methods: In this prospective, randomized study, chest compression without ventilation was performed for 4 min on a Resusci Anne manikin placed on a flat floor or on three types of home-bed mattresses (hard, medium and soft). Chest compression depth, chest compression rate and chest recoil were measured from the manikin with the Laerdal PC Skill Reporting System, and changes in chest compression quality using the four different surfaces were compared. Results: Thirty participants were enrolled to perform chest compression. There was no significant difference in chest compression depth and depth accuracy between the four surfaces. The median chest compression rates were 108.1 ± 8.5, 107.0 ± 8.3, 103.3 ± 8.9 and 98.3 ± 7.9 compressions/min ( p < 0.001) for the flat floor, hard-, medium-, and soft-firmness mattresses, respectively. Moreover, there was no a significant difference in chest recoil accuracy. Conclusion: Using a home-bed mattress did not decrease the chest compression quality, except chest compression rate of soft-firmness mattress. Thus, it may be effective to initiate chest compression on a home-bed mattress if the bystander cannot move the patient to the floor.
Videoconferencing psychotherapy for veterans with PTSD: Results from a randomized controlled non-inferiority trial
Authors: Liu Lin , Thorp Steven R , Moreno Lucy , Wells Stephanie Y , Glassman Lisa H , Busch Angela C , Zamora Tania , Rodgers Carie S , Allard Carolyn B , Morland Leslie A , Agha Zia 
Published: June 2019

Introduction Veterans with post-traumatic stress disorder (PTSD) face significant barriers that make it less likely for them to pursue treatment. A randomized controlled non-inferiority trial was used to determine if providing psychotherapy for PTSD via videoconference (VC) is as effective as in-person (IP) psychotherapy. Methods All eligible veterans ( n = 207) received cognitive processing therapy (CPT) to treat PTSD symptoms in one of the two treatment modalities. Participant symptoms were collected at baseline, post-treatment, and six months after treatment completion. The primary outcome measure, the Clinician-Administered PTSD Scale (CAPS), was used to assess PTSD diagnosis and symptom severity. Secondary outcomes included two self-report measures of symptom severity, the Post-traumatic Stress Disorder Checklist – Specific (PCL–S) for PTSD and the Patient Health Questionnaire – 9 (PHQ–9) for depressive symptoms. A linear mixed-effects model was used to assess non-inferiority for participants who completed treatment (completers) and those who were randomized to treatment (intention-to-treat (ITT)). Results Both completer and ITT analyses showed that improvement in CAPS scores in the VC condition was non-inferior to that in the IP condition at six-month follow-up, but VC was inferior to IP for improvement in CAPS at post-treatment. Non-inferiority was supported by completer analyses for PCL–S and PHQ–9 in both post-treatment change and six-month follow-up change, and the ITT analysis supported the significant non-inferiority for PCL at post-treatment change. Discussion These findings generally suggest that CPT delivered via VC can be as effective as IP for reducing the severity of PTSD symptoms.
The United States’ Regulatory Environment Is Evolving to Accommodate a Coming Boom in Gene Therapy Research
Authors: Eisenman Daniel 
Published: June 2019

Introduction: A dramatic increase in the number of clinical trials involving gene-modified cell therapy and gene therapy is taking place. The field is on the verge of a boom, and the regulatory environment is evolving to accommodate the growth. Discussion: This commentary summarizes the current state of the field, including an overview of the growth. The United States (US) regulatory structure for gene therapy will be summarized, and the evolution of the oversight structure will be explained. Conclusion: The gene therapy field has recently produced its first FDA-approved therapeutics and has a pipeline of other investigational products in the final stages of clinical trials before they can be evaluated by the FDA as safe and effective therapeutics. As research continues to evolve, so must the oversight structure. Biosafety professionals and IBCs have always played key roles in contributing to the safe, evidence-based advancement of gene therapy research. With the recent regulatory changes and current surge in gene therapy research, the importance of those roles has increased dramatically.
Phenomapping of subgroups in hypertensive patients using unsupervised data-driven cluster analysis: An exploratory study of the SPRINT trial
Authors: Yang Da-ya , Nie Zhi-qiang , Liao Li-zhen , Zhang Shao-zhao , Zhou Hui-min , Sun Xiu-ting , Zhong Xiang-bin , Du Zhi-min , Zhuang Xiao-dong , Liao Xin-xue 
Published: June 2019

Background Hypertensive patients are highly heterogeneous in cardiovascular prognosis and treatment responses. A better classification system with phenomapping of clinical features would be of greater value to identify patients at higher risk of developing cardiovascular outcomes and direct individual decision-making for antihypertensive treatment. Methods An unsupervised, data-driven cluster analysis was performed for all baseline variables related to cardiovascular outcomes and treatment responses in subjects from the Systolic Blood Pressure Intervention Trial (SPRINT), in order to identify distinct subgroups with maximal within-group similarities and between-group differences. Cox regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for cardiovascular outcomes and compare the effect of intensive antihypertensive treatment in different clusters. Results Four replicable clusters of patients were identified: cluster 1 (index hypertensives); cluster 2 (chronic kidney disease hypertensives); cluster 3 (obese hypertensives) and cluster 4 (extra risky hypertensives). In terms of prognosis, individuals in cluster 4 had the highest risk of developing primary outcomes. In terms of treatment responses, intensive antihypertensive treatment was shown to be beneficial only in cluster 4 (HR 0.73, 95% CI 0.55–0.98) and cluster 1 (HR 0.54, 95% CI 0.37–0.79) and was associated with an increased risk of severe adverse effects in cluster 2 (HR 1.18, 95% CI 1.05–1.32). Conclusion Using a data-driven approach, SPRINT subjects can be stratified into four phenotypically distinct subgroups with different profiles on cardiovascular prognoses and responses to intensive antihypertensive treatment. Of note, these results should be taken as hypothesis generating that warrant further validation in future prospective studies.
Sensitivity and Specificity of Gene Xpert in the Diagnosis of Spinal Tuberculosis: A Prospective Controlled Clinical Study
Authors: Solanki Anil M. , Basu Saumyajit , Biswas Amitava , Roy Subhendu , Banta Aditya 
Published: June 2019

Study Design: Prospective matched cohort study Objective: To evaluate the sensitivity and specificity of Gene Xpert in the diagnosis of spinal tuberculosis. Methods: From January 2016 to August 2018, Gene Xpert results were prospectively studied in 68 patients of clinicoradiologically suspected spinal tuberculosis (STB) and a control group (CG) of 92 patients, all of whom underwent computed tomography–guided/C-arm-guided/open surgical biopsy. Sensitivity, specificity, positive predictive value, and negative predictive value are obtained using standard equations. Results: Out of 68 cases of STB, Gene Xpert was positive in 62 (true positive: 62/68) and negative in 6 (false negative: 6/68). Gene Xpert was negative for all 92 cases of CG (true negative: 92/92, false positive 0/92). Thus, in our series, sensitivity of Gene Xpert is 91.18%, specificity is 100%, positive predictive value is 100%, and negative predictive value is 93.88%. Out of all cases of STB, 62/68 (91.18%) were Gene Xpert positive, but only 35/64 (54.69%) was acid-fast bacilli (AFB) culture positive and 53/60(88.33%) was histopathologically conclusive of TB. Also, Gene Xpert was positive in 7/7 (100%) cases of STB in which histopathology were inconclusive and 25/29 (86.21%) cases of STB in which AFB culture was negative. Conclusion: In STB, Gene Xpert clearly outperforms AFB culture and histopathology due to its high sensitivity and specificity apart from being rapid in diagnosis. Hence it is justified to diagnose spinal tuberculosis by Gene Xpert though histopathology is confirmative and AFB culture remains the gold standard.
Suicide Attempts and Pattern Among the Beginners and Established Female Commercial Sex Workers
Authors: G. V. Vaniprabha , S. Madhusudhan 
Published: June 2019

Objective: The purpose of this study was to explore the pattern of suicide and extent of depression among female commercial sex workers (CSWs). Methodology: 200 female CSWs classified as beginners and established depending on the number of years of sex work were referred to Victoria Hospital in Bengaluru, India, by an NGO called Swathi Mane which works for the betterment of these women. Results: The pattern of suicide and the number of attempts among both the groups were different indicating that the number of years of sex work played a major role among these women in deciding the number of attempts and pattern of suicide. The reasons for attempting suicide also are interesting to the fact that the women who are new to this profession suffer from depression and guilt and attempt suicide, while women who are into this profession for quite some time now are accustomed to this trade and have lesser or no suicide attempts. The depression scores among these two groups were also higher as per Hamilton Rating Scale for Depression scores.
Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning
Authors: van Besien Koen , Artz Andrew , Champlin Richard E. , Guarneri Danielle , Bishop Michael R. , Chen Julianne , Gergis Usama , Shore Tsiporah , Liu Hongtao , Rondon Gabriela , Mayer Sebastian A. , Srour Samer A. , Stock Wendy , Ciurea Stefan O. 
Published: June 2019

Abstract
Haplo-identical transplant with posttransplant cyclophosphamide (haplo) and umbilical cord blood transplant supported by third-party CD34 cells (haplo-cord) are competing approaches to alternative donor transplant. We compared, in adults younger than age 60 years, the outcomes of 170 haplo at 1 institution with that of 137 haplo-cord at 2 other institutions. All received reduced intensity conditioning with fludarabine and melphalan ± total body irradiation. GVHD prophylaxis for haplo consisted of cyclophosphamide, tacrolimus, and mycophenolate, whereas haplo-cord received antithymocyte globulin, tacrolimus, and mycophenolate. Haplo transplant used mostly bone marrow, and peripheral blood stem cells were used in haplo-cord transplants. Haplo-cord were older and had more advanced disease. Haplo-cord hastened median time to neutrophil (11 vs 18 days, P = .001) and platelet recovery (22 vs 25 days, P = .03). At 4 years, overall survival (OS) was 50% for haplo-cord vs 49% for haplo. Progression-free survival (PFS) was 40% for haplo-cord vs 45% for haplo. In multivariate analysis, the disease risk index was significant for OS (hazard ratio, 1.8; 95% confidence interval, 1.48-2.17; P = .00) and PFS. Total body irradiation was associated with decreased recurrence and improved PFS, age &gt;40 with increased nonrelapse mortality. The type of transplant had no effect on OS, PFS, relapse, or nonrelapse mortality. Cumulative incidence of grade 2-4 acute graft-versus-host disease (GVHD) by day 100 was 16% after haplo-cord vs 33% after haplo (P &lt; .0001), but grade 3-4 GVHD was similar. Chronic GVHD at 1 year was 4% after haplo-cord vs 16% after haplo (P &lt; .0001). Haplo or haplo-cord results in similar and encouraging outcomes. Haplo-cord is associated with more rapid neutrophil and platelet recovery and lower acute and chronic GVHD. Institutional review board authorization for this retrospective study was obtained at each institution. Some patients participated in trials registered at www.clinicaltrials.gov as #NCT01810588 and NCT 01050946.
Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
Authors: Keshavarz Mohsen , Solaymani-Mohammadi Farid , Miri Seyed Mohammad , Ghaemi Amir 
Published: June 2019

AbstractOncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via the release of damage-associated molecular patterns (DAMPs) and the activation of autophagy-related immunogenic cell death (ICD). Subsequent cross-presentation of tumor-associated antigens (TAA) through the MHC-I complex to CD8+ T cells results in the productive priming of the tumor-specific immune response. In this review, we first briefly discuss autophagy and explain the process of viral xenophagy. Finally, we focus on the interactions between virus and autophagy proteins, elaborating on the global preclinical studies on oncolytic paramyxoviruses.