bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL‐17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K/AKT signalling pathway
Authors: Zheng Qianqian , Diao Shuo , Wang Qi , Zhu Chen , Sun Xun , Yin Bo , Zhang Xinwen , Meng Xin , Wang Biao 
Published: October 2018

AbstractGlioblastomas (GBMs) are the most common of both benign and malignant primary brain tumours, in which the inflammatory and immunologic abnormalities are involved. Interleukin‐17A (IL‐17A) plays an important role in various inflammatory diseases and cancers. Several recent studies revealed that the expression of IL‐17A was overexpressed in human GBMs tissue. However, the accurate role of IL‐17A in GBMs remains unclear. In this study, we aimed to explore the effect of IL‐17A on cell migration and invasion of GBMs and the mechanism by which the effects occurred. We found that exogenous IL‐17A promoted significantly cell migration and invasion abilities in two GBMs cell lines (U87MG and U251) in a time‐dependent manner. In addition, the protein expressions of PI3K, Akt and MMP‐2/9 were increased in the GBMs cells challenged by IL‐17A. Furthermore, a tight junction protein ZO‐1 was down‐regulated but Twist and Bmi1 were up‐regulated. Treatment with a PI3K inhibitor (LY294002) significantly reduced the abilities of both migration and invasion in U87MG and U251 cells. LY294002 treatment also attenuated the IL‐17A causing increases of protein levels of PI3K, AKT, MMP‐2/9, Twist and the decreases of protein level of ZO‐1 in the U87MG and U251 cells. Taken together, we concluded that IL‐17A promotes the GBM cells migration and invasion via PI3K/AKT signalling pathway. IL‐17A and its related signalling pathways may be potential therapeutic targets for GBM.
Revealing the Environmental Advantages of Industrial Symbiosis in Wood‐Based Bioeconomy Networks: An Assessment From a Life Cycle Perspective
Authors: Hildebrandt Jakob , O'Keeffe Sinéad , Bezama Alberto , Thrän Daniela 
Published: October 2018

SummaryThe German government has recently initiated funding schemes that incentivize strategies for wood‐based bioeconomy regions. Regional wood and chemical industries have been encouraged to act symbiotically, that is, share pilot plant facilities, couple processes where feasible, and cascade woody feedstock throughout their process networks. However, during the planning stages of these bioeconomy regions, options need to be assessed for sustainably integrating processes and energy integration between the various industries that produce bio‐based polymers and engineered wood products. The aim of this paper is to identify the environmental sustainability of industrial symbiosis for producing high‐value‐added, bio‐based products in the wood‐based bioeconomy region of Central Germany. An analysis was conducted of three possible future scenarios with varying degrees of symbiosis in the bioeconomy network. A life cycle assessment (LCA) approach was used to compare these three scenarios to a traditional fossil‐based production system. Eleven environmental impact categories were considered. The results show that, in most cases, the bioeconomy network outperformed the fossil‐based production system, mitigating environmental impacts by 25% to 130%.
Association between sexual behavior and suicidal ideation among South Korean middle school students
Authors: Song Seunghun , Lee Gyuyoung 
Published: October 2018

AbstractAimTo identify the association between sexual behavior and suicidal ideation among South Korean middle school students.MethodsThis study used raw data from the 2013 Korean Youth Risk Behavior Web‐Based Survey. Among the data from 72,435 students, the data from 36,530 individuals in middle school were analyzed. The prevalence of sexual behavior and suicidal ideation, according to the participants’ general characteristics, and suicidal ideation, according to sexual behaviors, were assessed by using a complex sample Chi‐squared test. A complex sample logistic regression was used to examine the association between sexual behavior and suicidal ideation.ResultsOverall, 3.8% of the students reported having had sexual intercourse and 17.6% of the students reported suicidal ideation during the past 12 months. Having had sexual intercourse was statistically significantly associated with suicidal ideation. The students who had had sexual intercourse usually used contraception and those who had contracted sexually transmitted diseases were more likely to report suicidal ideation in both the unadjusted and adjusted models.ConclusionThis study illustrates the need to develop a prevention program that addresses the common factors between sexual behavior and suicidal ideation in order to effectively reduce both sexual behavior and suicidal ideation in middle school students.
Care Personnel's Attitudes and Fears Toward Care Robots in Elderly Care: A Comparison of Data from the Care Personnel in Finland and Japan
Authors: Coco Kirsi , Kangasniemi Mari , Rantanen Teemu 
Published: October 2018

AbstractPurposeThe aim of the study was to analyze and compare elderly care personnel attitudes toward care robots in Finland and Japan.DesignCross‐sectional survey in Finland and Japan.MethodsThe Finnish sample was collected from care personnel in home care facilities in five municipalities in 2016. The Japanese sample was collected from personnel in two rehabilitative day centers and three residential care homes for the elderly in the north of Honshu Island in 2017. The data were analyzed using basic statistical methods and calculated descriptive statistics (frequencies). Differences between the Finnish and Japanese data have been analyzed using the Mann‐Whitney U test.FindingsOverall, Japanese care personnel assessed the usefulness of robots more positively than did their Finnish counterparts. The data showed substantial national differences in the perceived importance of various potential tasks for care robots. The findings show that there are also certain fears related to the introduction of care robots, in particular among the Finnish care personnel.DiscussionThe data from the Japanese care personnel bring new perspectives to the concept of a close human–robot relationship. The differences seen in the results between Finland and Japan can be partly explained by cultural dissimilarity, but it is also known that Japan is a more developed country with regard to the use of robotics in nursing care. The research highlights the importance of cultural factors when examining the issue of care robotics. The factors affecting fear are a concern that care robots would be used to replace people, the dehumanization of treatment, and an increased loneliness in the elderly. Thus, further research is required to demonstrate the relationship between different cultural factors, and attitudes and conceptions toward care robots.Clinical RelevanceManagement plays a key role when implementing robotics. It is important to help care personnel accept care robots, and to diminish any fears that their introduction would make the treatment of elderly people inhumane or in some way add to their loneliness. As such, education is crucial in changing attitudes and making care personnel understand that care robots can perform routine tasks, allowing care personnel to focus on providing improved care and nursing.
Nursing knowledge of essential maternal and newborn care in a high‐mortality urban African setting: A cross‐sectional study
Authors: Murphy Georgina A. V. , Gathara David , Mwaniki Ann , Nabea Grace , Mwachiro Jacintah , Abuya Nancy , English Mike 
Published: October 2018

AbstractAimsTo assess the knowledge of nurses of national guidelines for emergency maternity, routine newborn and small and sick newborn care in Nairobi County, Kenya.BackgroundThe vast majority of women deliver in a health facility in Nairobi. Yet, maternal and neonatal mortality remain high. Ensuring competency of health workers, in providing essential maternal and newborn interventions in health facilities will be key if further progress is to be made in reducing maternal and neonatal mortality in low‐resource settings.DesignCross‐sectional survey.MethodsQuestionnaires comprised of clinical vignettes and direct questions and were administered in 2015–2016 to nurses (n = 125 in 31 facilities) on duty in maternity and newborn units in public and private facilities providing 24/7 inpatient neonatal services. Composite knowledge scores were calculated and presented as weighted means. Associations were explored using regression. STROBE guidelines were followed.ResultsNurses scored best for knowledge on active management of the mother after birth and immediate routine newborn care. Performance was worst for questions on infant resuscitation, checking signs and symptoms of sick newborns, and managing hypertension in pregnancy. Overall knowledge of care for sick newborns was particularly low (score 0.62 of 1). Across all areas assessed, nurses who had received training since qualifying performed better than those who had not. Poorly resourced and low case‐load facilities had lower average knowledge scores compared with better‐resourced and busier facilities.ConclusionOverall, we estimate that 31% of maternity patients, 3% of newborns and 39% of small and sick newborns are being cared for in an environment where nursing knowledge is very low (score <0.6).Relevance to clinical practiceFocus on periodic training, ensuring retention of knowledge and skills among health workers in low‐case load setting, and bridging the know‐do gap may help to improve the quality of care delivered to mothers and newborns in Kenya.
Communication training and its effects on carer and care‐receiver outcomes in dementia settings: A systematic review
Authors: Nguyen Hoang , Terry Daniel , Phan Hoang , Vickers James , McInerney Fran 
Published: October 2018

AbstractAims and objectivesTo review communication interventions that aim to improve regular care interactions between people with dementia and their carers in various settings; and to examine the impact of such interventions on both carer and care‐receiver outcomes.BackgroundEffective communication is imperative to ensure quality of care for people living with dementia. Due to neurodegenerative changes, people with dementia encounter ongoing and progressive difficulties in both understanding and expressing themselves. This in turn creates challenges for carers, which highlights the need for equipping them with necessary communication skills to respond to the specific communication needs of people with dementia.DesignSystematic review and meta‐analysis.MethodMedline, Embase, CINAHL, ProQuest and PsycINFO databases were searched for eligible interventions with any date of the publication. Hand searching was also conducted through reviewing the reference lists of relevant articles. The screening and selection of studies were based on the inclusion/exclusion criteria for eligibility and the methodological quality assessment checklist. Random‐effects meta‐analyses were conducted on comparable quantitative data. The review is reported following the PRISMA reporting guidelines.ResultsSeventeen studies were included in the final review, including 12 randomised controlled trials (RCTs), three nonrandomised controlled trials (NRCTs) and two controlled before–after interventions. The intervention designs, settings and outcome measures were varied. The findings suggest that the communication training had a positive impact on both carer and care‐receiver outcomes, albeit to different degrees. The intervention effects were found to be strongest on carer communication skills and knowledge.ConclusionThere is solid evidence for the positive impact of communication training on the skills and knowledge of carers. More research is needed regarding the effects of such educational interventions on carer physio‐psychological outcomes and care‐receiver neuropsychiatric symptoms. It is important to establish best practices in training design, develop validated outcome measures and adopt consistent reporting approaches.Relevance to clinical practiceThe increasing global prevalence of people with dementia manifests across clinical and community contexts. The profound impact of dementia on communication and associated care raises the imperative for enhanced health worker and carer communication skills to meet the needs of this particular client group. The findings of this review indicate that educational interventions incorporating face‐to‐face and diverse instructional delivery methods in dementia communication showed positive outcomes for communication skills in all carer groups and warrant inclusion as strategies in dementia training.
Breast cancer survivors' experiences of dealing with information during and after adjuvant treatment: A qualitative study
Authors: Aunan Siv Tove , Wallgren Gry Ciekals , Sætre Hansen Britt 
Published: October 2018

AbstractAims and objectivesTo describe breast cancer (BC) survivors' experiences of participating in a 2‐day educational programme (Breast Cancer School, BCS) and their critical reflection on information received during and after adjuvant treatment. The following research questions guided the study. How do BC survivors experience their participation in an educational programme? How do BC survivors experience the information trajectory during and after adjuvant treatment?BackgroundBC is the most prevalent cancer among women in Norway. BC survivors have a substantial need for information about the disease, treatment and recovery. During the past few years, BC treatment in Norway has changed from inpatient‐ to outpatient‐based treatment. Oncology nurses and oncologists are obliged to provide patients and their families with information, which has necessitated reorganisation of the procedures for providing information. New arenas such as the Breast Cancer School (BCS) offer the opportunity to learn from experts and fellow patients.DesignQualitative, descriptive design.MethodsFocus groups with 20 BC survivors after having participated in the BCS were used to enable critical reflection. The COREQ checklist was followed to ensure rigour in the study.ResultsTwo themes emerged from qualitative analysis: Balancing between the need for and the fear of information and Moving from a safe structure to lonely recovery. We identified differences between BC survivors in diversity, uniqueness and need for information. Continuity and expert knowledge provided by a primary oncology nurse and oncologists were highlighted as important.ConclusionThe study reveals the need for information tailored to each BC survivor's unique needs. The BC survivors expressed both the need for and the fear of information. BCS takes both a systematic and individual approach to provide expert information, dialog and the opportunity to meet with fellow patients. The transition from the structure of the treatment to lonely recovery after the most intensive treatment was perceived as unsafe and challenging. BC patients' experiences must be continuously valued and used to improve educational programmes, care and treatment. Oncology nurses play an important part in the information chain and continuity.Relevance to clinical practiceThis study highlights the importance of including BC survivors in the design and evaluation of educational programmes. The provision of information and supportive care with continuity between oncology nurses and oncologists through the trajectory of treatment and care is crucial.
A qualitative analysis of eating behaviour change for patients with diabetes and non‐dialysis dependent chronic kidney disease stages 4–5
Authors: Notaras Stephanie , Conti Janet 
Published: October 2018

SUMMARYBackgroundDietary changes recommended for chronic kidney disease (CKD) stages 4–5 and concurrent diabetes are difficult to follow given the multitude of food and fluid restrictions aimed at reducing the rate of CKD progression. Reduced adherence is commonplace and there is limited literature on patients’ experiences with dietary changes and potential strategies to overcome this.ObjectivesExamine patients’ experiences when adopting dietary changes recommended for CKD Stages 4–5 (pre‐dialysis) and diabetes, and their perceptions of dietetic services and how they can be improved to assist them with dietary change.MethodsAn exploratory qualitative study was undertaken using a purposive sampling method from a dietetic pre‐dialysis clinic. Participants were interviewed using a semi‐structured interview style. Data were analysed using an inductive thematic analysis from a constructivist perspective.ResultsThree themes were identified: (1) Negative motivation to change eating behaviour to avoid dialysis; (2) sustaining motivation for change is challenging due to a sense of loss and confusion to incorporate the dietary changes recommended and (3) support is needed for eating behaviour change.ConclusionThese findings have implications for dietitians to enhance their understanding of the patient experience and improve their skills in motivational counselling. Development of dietitian‐specific communication and nutrition counselling programmes are recommended to equip dietitians with skills to better support patients. CKD Stage 3 nutrition education programmes could be beneficial to promote earlier access to dietetic services and dietary recommendations.
Petrography and geochemistry of lunar meteorites Dhofar 1673, 1983, and 1984
Authors: Hill Patrick J. A. , Osinski Gordon R. , Banerjee Neil R. , Korotev Randy L. , Nasir Sobhi J. , Herd Christopher D. K. 
Published: October 2018

AbstractThe Dhofar 1673, Dhofar 1983, and Dhofar 1984 meteorites are three lunar regolith breccias classified based on their petrography, mineralogy, oxygen isotopes, and bulk chemistry. All three meteorites are dominated by feldspathic lithic clasts; however, impact melt rock clasts and spherules are also found in each meteorite. The bulk chemistry of these samples is similar to other feldspathic highland meteorites with the Al2O3 content only slightly lower than average. Within the lithic clasts, the Mg # of mafic phases versus the anorthite content of feldspars is similar to other highland meteorites and is found to plot intermediate of the ferroan‐anorthositic suite and magnesian suite. The samples lack any KREEPy signature and have only minor indications of a mare basalt component, suggesting that the source region of all three meteorites would have been distal from the Procellarum KREEP Terrane and could have possibly been the Feldspathic Highland Terrane. All three meteorites were found within 500 m of each other in the Dhofar region of Oman. This, together with their similar petrography, stable isotope chemistry, and geochemistry indicates the possibility of a pairing.
Untangling the knots: Co‐infection and diversity of Bartonella from wild gerbils and their associated fleas
Authors: Gutiérrez Ricardo , Cohen Carmit , Flatau Ron , Marcos‐Hadad Evgeniya , Garrido Mario , Halle Snir , Nachum‐Biala Yaarit , Covo Shay , Hawlena Hadas , Harrus Shimon 
Published: October 2018

AbstractBased on molecular data, previous studies have suggested a high overall diversity and co‐infection rates of Bartonella bacteria in wild rodents and their fleas. However, partial genetic characterization of uncultured co‐infecting bacteria limited sound conclusions concerning intra‐ and inter‐specific diversity of the circulating Bartonella. To overcome this limitation, Bartonella infections of wild populations of two sympatric gerbil species and their fleas were explored by multiple isolations of Bartonella organisms. Accordingly, 448 pure Bartonella isolates, obtained from 20 rodent blood and 39 flea samples, were genetically characterized to the genotype and species levels. Results revealed a remarkable diversity and co‐infection rates of Bartonella among these sympatric rodents and their associated fleas. Specifically, 38 genotypes, classified into four main Bartonella species, were identified. Co‐infection was confirmed in 56% of the samples, which contained two to four Bartonella genotypes per sample, belonging to up to three different species. Recombination within and between these species was demonstrated, serving as a direct evidence of the frequent bacteria–bacteria interactions. Moreover, despite the noticeable interchange of common Bartonella genotypes between rodents and fleas, the co‐occurrence of genotypes was not random and differences in the overall diversity, and the ecological and phylogenetic similarities of the infection compositions were significantly associated with the carrier type (rodent vs. flea) and the rodent species. Thus, comprehensive identification of the co‐infecting organisms enabled the elucidation of ecological factors affecting the Bartonella distribution among reservoirs and vectors. This study may serve as a model for the investigation of other vector‐borne organisms and their relationships with Bartonella.
Classical Planning Model‐Based Approach to Automating Construction Planning on Earthwork Projects
Authors: Li Duanshun , Lu Ming 
Published: October 2018

AbstractExtensive research in automated operation planning has led to significant advances in the area of robotics. Theories and methods resulting from robotics have yet to be adapted to enable automated project planning in construction engineering. Aiming to demonstrate the potential of implementing automated planning theory and methods in construction project planning, we developed an automated earthwork planner prototype following the principles and framework of classical planning model in computer science. As time is not explicitly represented, implementing classical planning model to perform optimization and planning simultaneously results in potential temporal–spatial conflicts (TSCs). The present research develops a two‐step approach to separate operations optimization and earthwork planning in typical rough grading projects. As such, TSCs encountered in existing mathematical programming based earthwork planning methods are resolved. To enable fully integrated and automated earthwork planning, the prototype system has been seamlessly integrated with project scheduling and operations simulation software for higher level analyses. To demonstrate advantages of the automated planning methodology, construction plans were independently produced by 14 graduate student teams on the same “testbed” project; results were evaluated and compared with the plan generated by the proposed system.