bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educating physicians in seventeenth-century England - ADDENDUM
Authors: Barry Jonathan 
Published: August 2019

ArgumentThe tension between theoretical and practical knowledge was particularly problematic for trainee physicians. Unlike civic apprenticeships in surgery and pharmacy, in early modern England there was no standard procedure for obtaining education in the practical aspects of the physician’s role, a very uncertain process of certification, and little regulation to ensure a suitable reward for their educational investment. For all the emphasis on academic learning and international travel, the majority of provincial physicians returned to practice in their home area, because establishing a practice owed more to networks of kinship, patronage and credit than to formal qualifications. Only when (and where) practitioners had to rely solely on their professional qualification to establish their status as young practitioners that the community could trust would proposals to reform medical education, such as those put forward to address a crisis of medicine in Restoration London, which are examined here, be converted into national regulation of medical education in the early nineteenth century, although these proposals prefigured many informal developments in medical training in the eighteenth century.
Interspeaker covariation in Philadelphia vowel changes
Authors: Tamminga Meredith 
Published: August 2019

AbstractThe paper asks whether six ongoing vowel changes in Philadelphia English show interspeaker covariation. In a sample of 66 young white women, pairwise correlations are significant only between three changes that have previously been observed to show parallel diachronic trajectories of change reversal, whereas changes that do not exhibit this diachronic pattern do not show covariation. I propose that the interspeaker covariation in this subset of the changes in progress arises from a shared social motivation for the change reversals that is not shared by the other changes.
Group versus individual format of intervention for aggressive children: Moderators and predictors of outcomes through 4 years after intervention
Authors: Lochman John E. , Glenn Andrea L. , Powell Nicole P. , Boxmeyer Caroline L. , Bui Chuong , Kassing Francesca , Qu Lixin , Romerro Devon E. , Dishion Thomas 
Published: August 2019

AbstractThis study originated in collaboration with Thomas Dishion because of concerns that a group format for aggressive children might dampen the effects of cognitive-behavioral intervention. Three hundred sixty aggressive preadolescent children were screened through teacher and parent ratings. Schools were randomized to receive either an individual or a group format of the child component of the same evidence-based program. The results indicate that there is variability in how group-based cognitive-behavioral intervention can affect aggressive children through a long 4-year follow-up after the end of the intervention. Aggressive children who have higher skin conductance reactivity (potentially an indicator of poorer emotion regulation) and who have a variant of the oxytocin receptor gene that may be associated with being hyperinvolved in social bonding have better outcomes in their teacher-rated externalizing behavior outcomes over time if they were seen individually rather than in groups. Analyses also indicated that higher levels of the group leaders’ clinical skills predicted reduced externalizing behavior problems. Implications for group versus individual format of cognitive-behavioral interventions for aggressive children, and for intensive training for group therapists, informed by these results, are discussed.
Adipose-derived stem cells transplantation improves endometrial injury repair
Authors: Shao Xiaowen , Ai Guihai , Wang Lian , Qin Jinlong , Li Yue , Jiang Huici , Zhang Tingting , Zhou Linlin , Gao Zhengliang , Cheng Jiajing , Cheng Zhongping 
Published: August 2019

SummaryEndometrial injury is an important cause of intrauterine adhesion (IUA), amenorrhea and infertility in women, with limited effective therapies. Recently, stem cells have been used in animal experiments to repair and improve injured endometrium. To date, our understanding of adipose-derived stem cells (ADSCs) in endometrial injury repair and their further therapeutic mechanisms is incomplete. Here, we examined the benefit of ADSCs in restoration of injured endometrium by applying a rat endometrial injury model. The results revealed by immunofluorescence showed that green fluorescent protein (GFP)-labelled ADSCs can differentiate into endometrial epithelial cells in vivo. At 30 days after ADSCs transplantation, injured endometrium was significantly improved, with increased microvessel density, endometrial thickness and glands when compared with the model group. Furthermore, the fertility of rats with injured endometrium in ADSCs group was improved and had a higher conception rate (60% vs 20%, P = 0.014) compared with the control phosphate-buffered saline (PBS) group. However, there was no difference in the control group compared with the sham group. In addition, expression levels of the oestrogen receptor Eα/β (ERα, ERβ) and progesterone receptor (PR) detected by western blot and enzyme-linked immunosorbent assay (ELISA) were higher in the ADSCs group than in the PBS group. Taken together, these results suggested that ADSC transplantation could improve endometrial injury as a novel therapy for IUA.
Mothers’ beliefs about indigenous and traditional food affordability, availability and taste are significant predictors of indigenous and traditional food consumption among mothers and young children in rural Kenya
Authors: Gewa Constance Awuor , Onyango Agatha Christine , Obondo Angano Frederick , Stabile Bonnie , Komwa Maction , Thomas Phil , Krall Jenna 
Published: August 2019

AbstractObjective:To examine mothers’ and young children’s consumption of indigenous and traditional foods (ITF), assess mothers’ perception of factors that influence ITF consumption, and examine the relationship between perceived factors and ITF consumption.Design:Longitudinal study design across two agricultural seasons. Seven-day FFQ utilized to assess dietary intake. Mothers interviewed to assess their beliefs about amounts of ITF that they or their young children consumed and on factors that influence ITF consumption levels.Setting:Seme sub-County, Kenya.Participants:Mothers with young children.Results:Less than 60 % of mothers and children consumed ITF at time of assessment. Over 50 % of the mothers reported that their ITF consumption amounts and those of their children were below levels that mothers would have liked for themselves or for their young children. High cost, non-availability and poor taste were top three reasons for low ITF consumption levels. Mothers who identified high cost or non-availability as a reason for low levels of ITF consumption had significantly lower odds of consuming all ITF except amaranth leaves. Mothers who identified poor taste had significantly lower odds of consuming all ITF except green grams and groundnuts. Similar relationships were noted for young children’s ITF consumption levels.Conclusions:A majority of the mothers reported that they and their children did not consume as much ITF as the mothers would have liked. Further studies should examine strategies to improve availability and affordability of ITF, as well as develop recipes that are acceptable to mothers and children.
EQUIVARIANT ALGEBRAIC INDEX THEOREM
Authors: Gorokhovsky Alexander , de Kleijn Niek , Nest Ryszard 
Published: August 2019

AbstractWe prove a $\unicode[STIX]{x1D6E4}$-equivariant version of the algebraic index theorem, where $\unicode[STIX]{x1D6E4}$ is a discrete group of automorphisms of a formal deformation of a symplectic manifold. The particular cases of this result are the algebraic version of the transversal index theorem related to the theorem of A. Connes and H. Moscovici for hypo-elliptic operators and the index theorem for the extension of the algebra of pseudodifferential operators by a group of diffeomorphisms of the underlying manifold due to A. Savin, B. Sternin, E. Schrohe and D. Perrot.
Twelve-month mental health service use in six countries of the Americas: A regional report from the World Mental Health Surveys
Authors: Borges G. , Aguilar-Gaxiola S. , Andrade L. , Benjet C. , Cia A. , Kessler R. C. , Orozco R. , Sampson N. , Stagnaro J. C. , Torres Y. , Viana Maria Carmen , Medina-Mora M. E. 
Published: August 2019

Abstract

Aims
To provide cross-national data for selected countries of the Americas on service utilization for psychiatric and substance use disorders, the distribution of these services among treatment sectors, treatment adequacy and factors associated with mental health treatment and adequacy of treatment.

Methods
Data come from data collected from 6710 adults with 12 month mental disorder surveys across seven surveys in six countries in North (USA), Central (Mexico) and South (Argentina, Brazil, Colombia, Peru) America who were interviewed 2001–2015 as part of the World Health Organization (WHO) World Mental Health (WMH) Surveys. DSM-IV diagnoses were made with the WHO Composite International Diagnostic Interview (CIDI). Interviews also assessed service utilization by the treatment sector, adequacy of treatment received and socio-demographic correlates of treatment.

Results
Little over one in four of respondents with any 12 month DSM-IV/CIDI disorder received any treatment. Although the vast majority (87.1%) of this treatment was minimally adequate, only 35.3% of cases received treatment that met acceptable quality guidelines. Indicators of social-advantage (high education and income) were associated with higher rates of service use and adequacy, but a number of other correlates varied across survey sites.

Conclusions
These results shed light on an enormous public health problem involving under-treatment of common mental disorders, although the problem is most extreme among people with social disadvantage. Promoting services that are more accessible, especially for those with few resources, is urgently needed.
Management of pigweed (Amaranthusspp.) in grain sorghum with integrated strategies
Authors: Hay Marshall M. , Dille J. Anita , Peterson Dallas E. 
Published: August 2019

AbstractPigweed is difficult to manage in grain sorghum because of widespread herbicide resistance, a limited number of registered effective herbicides, and the synchronous emergence of pigweed with grain sorghum in Kansas. The combination of cultural and mechanical control tactics with an herbicide program are commonly recognized as best management strategies; however, limited information is available to adapt these strategies to dryland systems. Our objective for this research was to assess the influence of four components, including a winter wheat cover crop (CC), row-crop cultivation, three row widths, with and without a herbicide program, on pigweed control in a dryland system. Field trials were implemented during 2017 and 2018 at three locations for a total of 6 site-years. The herbicide program component resulted in excellent control (>97%) in all treatments at 3 and 8 weeks after planting (WAP). CC provided approximately 50% reductions in pigweed density and biomass for both timings in half of the site-years; however, mixed results were observed in the remaining site-years, ranging from no attributable difference to a 170% increase in weed density at 8 WAP in 1 site-year. Treatments including row-crop cultivation reduced pigweed biomass and density in most site-years 3 and 8 WAP. An herbicide program is required to achieve pigweed control and should be integrated with row-crop cultivation or narrow row widths to reduce the risk of herbicide resistance. Additional research is required to optimize the use of CC as an integrated pigweed management strategy in dryland grain sorghum.
Eddy‐Induced Transport of Saline Kuroshio Water Into the Northern South China Sea
Authors: Yang Yikai , Wang Dongxiao , Wang Qiang , Zeng Lili , Xing Tao , He Yunkai , Shu Yeqiang , Chen Ju , Wang Yinxia 
Published: August 2019

AbstractTo better understand eddy‐induced heat and salt transport, a targeted joint hydrographic investigation focusing on an anticyclonic eddy was carried out in July 2017 in the northern South China Sea. In situ and satellite observations together with Hybrid Coordinate Ocean Model (HYCOM) output show the transport of subsurface saline Kuroshio water into the northern South China Sea by an anticyclonic eddy. Subsurface high‐salinity cores are consistent with the anticyclonic eddy centers. The transport of saline Kuroshio water occurs in two stages accompanied by eddy shedding. First, saline Kuroshio water is trapped within the anticyclonic eddy at its generation location. Then, although the salinity within the eddy gradually weakens as the eddy carries the saline water westward, the quantity of saline water (>34.70 psu) shows a sharp increase, dominated by eddy‐induced salinity advection. A diagnosis of the salinity budget further confirms that the contribution of eddy flow advection is greater than that of mean flow advection. The saline Kuroshio water is trapped and conveyed in this anticyclonic eddy, providing vital evidence and important implications for eddy‐induced salt transport and water exchange.
Thickness of Lunar Mare Basalts: New Results Based on Modeling the Degradation of Partially Buried Craters
Authors: Du Jun , Fa Wenzhe , Wieczorek Mark A. , Xie Minggang , Cai Yuzhen , Zhu Meng‐Hua 
Published: August 2019

AbstractPartially buried craters on the Moon are those craters whose distal ejecta are covered by lava flows and where the crater rim crest still protrudes above the mare plain. Based on the difference in rim heights between a partially buried crater and an unburied crater, previous studies estimated the thicknesses of the lunar mare basalts. However, these studies did not consider the erosion of the crater rim height, which can result in an overestimate in the derived thickness. By using recent high‐resolution topographic data, we report a basalt thickness estimation method based on numerically modeling the topographic degradation of partially buried craters. We identified 661 buried craters over the lunar surface, and their spatial distribution suggests a preferential occurrence along the mare‐highland boundaries. An elevation model of fresh lunar craters was derived, and the topographic diffusion equation was used to model crater degradation. By modeling the formation, degradation, and flooding of partially buried craters, basalt thicknesses were estimated for 41 mare craters whose rims are completely exposed. The resulting mare basalt thicknesses vary from 33 to 455 m, with a median value of 105 m that is 95 m smaller than that derived when not considering crater degradation. The estimated eruption rate of lunar mare basalts is found to have peaked at 3.4 Ga and then decreased with time, indicating a progressive cooling of the lunar interior. As a by‐product from the crater degradation model, our results suggest that the topographic diffusivity of lunar craters increases with diameter.
Nature-inspired chiral metasurfaces for circular polarization detection and full-Stokes polarimetric measurements
Authors: Basiri Ali , Chen Xiahui , Bai Jing , Amrollahi Pouya , Carpenter Joe , Holman Zachary , Wang Chao , Yao Yu 
Published: August 2019

AbstractThe manipulation and characterization of light polarization states are essential for many applications in quantum communication and computing, spectroscopy, bioinspired navigation, and imaging. Chiral metamaterials and metasurfaces facilitate ultracompact devices for circularly polarized light generation, manipulation, and detection. Herein, we report bioinspired chiral metasurfaces with both strong chiral optical effects and low insertion loss. We experimentally demonstrated submicron-thick circularly polarized light filters with peak extinction ratios up to 35 and maximum transmission efficiencies close to 80% at near-infrared wavelengths (the best operational wavelengths can be engineered in the range of 1.3–1.6 µm). We also monolithically integrated the microscale circular polarization filters with linear polarization filters to perform full-Stokes polarimetric measurements of light with arbitrary polarization states. With the advantages of easy on-chip integration, ultracompact footprints, scalability, and broad wavelength coverage, our designs hold great promise for facilitating chip-integrated polarimeters and polarimetric imaging systems for quantum-based optical computing and information processing, circular dichroism spectroscopy, biomedical diagnosis, and remote sensing applications.
Subwavelength polarization optics via individual and coupled helical traveling-wave nanoantennas
Authors: Wang Mengjia , Salut Roland , Lu Huihui , Suarez Miguel-Angel , Martin Nicolas , Grosjean Thierry 
Published: August 2019

AbstractLight polarization control is a key factor in modern photonics. Recent advances in surface plasmon manipulation have introduced the prospect of more compact and more efficient devices for this purpose. However, the current plasmonic-based polarization optics remain much larger than the wavelength of light, which limits the design degrees of freedom. Here, we present a plasmonic traveling-wave nanoantenna using a gold-coated helical carbon nanowire end-fired with a dipolar aperture nanoantenna. Our nonresonant helical nanoantenna enables tunable polarization control by swirling surface plasmons on the subwavelength scale and taking advantage of the optical spin–orbit interaction. Four closely packed helical traveling-wave nanoantennas (HTNs) are demonstrated to locally convert an incoming light beam into four beams of tunable polarizations and intensities, with the ability to impart different polarization states to the output beams in a controllable way. Moreover, by near-field coupling four HTNs of opposite handedness, we demonstrate a subwavelength waveplate-like structure providing a degree of freedom in polarization control that is unachievable with ordinary polarization optics and current metamaterials.
Inhibitory effects of pu-erh tea on alpha glucosidase and alpha amylase: a systemic review
Authors: Yang Chiung-Ying , Yen Yea-Yin , Hung Kuang-Chen , Hsu Shang-Wei , Lan Shou-Jen , Lin Hsin-Cheng 
Published: August 2019

Abstract
Objective
Pu-erh tea was presumed to have anti-hyperglycemic effects via inhibition on alpha-amylase and alpha-glucosidase. However, no integerated literatures were published to substantiate such presumption.

Methods
Current study adopted systemic review method to validate inhibitory effects on alpha amylase and alpha-glucosidase. Five English databases (PubMed, EBSCO, SCOPUS, Cochrane Library, Web of Science) and three Chinese ones (Airti Library, CNKI Library, and Google Scholar) were searched up to 22 March 2018 for eligible literatures, using keywords of Pu-erh, Pu’er, alpha-amylase or alpha-glucosidase.

Results
Six studies exploring inhibitory effects on alpha-glucosidase and seven on alpha-amylase were included for systemic review. Though results showed pu-erh tea has significant inhibitory effects on alpha-amylase and alpha-glucosidase, high heterogeneity was detected among studies included.

Conclusions
High heterogeneity may be due to complex alterations of chemicals under different degrees of fermentation. More future studies are required to further identify principal bioactive component(s) at work.
NURR1 deficiency is associated to ADHD-like phenotypes in mice
Authors: Montarolo Francesca , Martire Serena , Perga Simona , Spadaro Michela , Brescia Irene , Allegra Sarah , De Francia Silvia , Bertolotto Antonio 
Published: August 2019

AbstractThe transcription factor NURR1 regulates the dopamine (DA) signaling pathway and exerts a critical role in the development of midbrain dopaminergic neurons (mDA). NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson’s disease and schizophrenia. However, the association between NURR1 defects and the attention-deficit hyperactivity disorder (ADHD), a DA-associated brain disease characterized by hyperactivity, impulsivity and inattention, has never been demonstrated. To date, a comprehensive murine model of ADHD truly reflecting the whole complex human psychiatric disorder still does not exist. NURR1-knockout (NURR1-KO) mice have been reported to exhibit increased spontaneous locomotor activity, but their complete characterization is still lacking. In the present study a wide-ranging test battery was used to perform a comprehensive analysis of the behavioral phenotype of the male NURR1-KO mice. As a result, their hyperactive phenotype was confirmed, while their impulsive behavior was reported for the first time. On the other hand, no anxiety and alterations in motor coordination, sociability and memory were observed. Also, the number of mDA expressing tyrosine hydroxylase, a rate-limiting enzyme of catecholamines biosynthesis, and DA level in brain were not impaired in NURR1-KO mice. Finally, hyperactivity has been shown to be recovered by treatment with methylphenidate, the first line psychostimulant drug used for ADHD. Overall, our study suggests that the NURR1 deficient male mouse may be a satisfactory model to study some ADHD behavioral phenotypes and to test the clinical efficacy of potential therapeutic agents.
Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
Authors: Kim Jin Yong , Ohn Jungyoon , Yoon Ji-Seon , Kang Bo Mi , Park Minji , Kim Sookyung , Lee Woochan , Hwang Sungjoo , Kim Jong-Il , Kim Kyu Han , Kwon Ohsang 
Published: August 2019

AbstractThe maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little is known about how adult stem cells respond to irreversible DNA damage, resulting in loss of regeneration in humans. Here, we establish a permanent regeneration loss model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. We uncover the underlying mechanisms by which hair follicle stem cells (HFSCs) lose their pool. In contrast to immediate destructive changes in rapidly proliferating hair matrix cells, quiescent HFSCs show unexpected massive proliferation after busulfan and then undergo large-scale apoptosis following cyclophosphamide. HFSC proliferation is activated through PI3K/Akt pathway, and depletion is driven by p53/p38-induced cell death. RNA-seq analysis shows that HFSCs experience mitotic catastrophe with G2/M checkpoint activation. Our findings indicate that priming mobilization causes stem cells to lose their resistance to DNA damage, resulting in permanent loss of regeneration after alkylating chemotherapy.
Thermodynamic efficiency in dissipative chemistry
Authors: Penocchio Emanuele , Rao Riccardo , Esposito Massimiliano 
Published: August 2019

AbstractChemical processes in closed systems inevitably relax to equilibrium. Living systems avoid this fate and give rise to a much richer diversity of phenomena by operating under nonequilibrium conditions. Recent experiments in dissipative self-assembly also demonstrated that by opening reaction vessels and steering certain concentrations, an ocean of opportunities for artificial synthesis and energy storage emerges. To navigate it, thermodynamic notions of energy, work and dissipation must be established for these open chemical systems. Here, we do so by building upon recent theoretical advances in nonequilibrium statistical physics. As a central outcome, we show how to quantify the efficiency of such chemical operations and lay the foundation for performance analysis of any dissipative chemical process.