bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformation of grade II to grade III rhabdoid-papillary meningioma: Is SRS the culprit?
Authors: Christodoulides Ioannis , Pedro Lavrador Jose , Vergani Francesco , Bhangoo Ranjeev , Gullan Richard , Ashkan Keyoumars 
Published: October 2019

Abstract

Objectives
Meningiomas demonstrate specific genetic and epigenetic mutations, whose effect on recurrence and progression is still of limited understanding. Single-fraction stereotactic radiosurgery (SRS) is an established alternative treatment to surgical resection, proven to achieve excellent local disease control with minimal side effects. However, its effects on tumorigenesis and malignant transformation are still uncertain. The published estimated risk ranges from 0.04%-2.6% at 15 years.

Design
Case report

Subjects
Female patient referred to our neurosurgical service

Methods
Retrospective analysis of patient’s notes, histopathology reports, clinic letters, MDT decisions and imaging studies

Results
This report describes a case of a grade II parafalcine meningioma, that was initially resected with a Simpson 2 clearance, and upon recurrence, was managed with a single dose of SRS. More than 7 years later, the meningioma recurred, and due to its increasing size on follow-up imaging, it was re-resected. Histopathology revealed a grade III rhabdoid-papillary lesion, with local brain invasion.

Conclusions
To our knowledge, this was the first report to describe malignant transformation of a grade II to a grade III meningioma following SRS therapy to date. Therefore, considering the recent trend towards SRS-treatment for meningiomas, the treating team should always consider its potential effects on tumorigenesis.
Nondetectable or minimal detectable residue levels of N-(n-butyl) thiophosphoric triamide in bovine tissues and milk from a 28-d NBPT dosing study
Authors: van de Ligt Jennifer , Borghoff Susan J , Yoon Miyoung , Ferguson Lin J , DeMaio William , McClanahan Robert H 
Published: October 2019

Abstract
N-(n-butyl) thiophosphoric triamide (NBPT) (Figure 1) is an active ingredient in nitrogen stabilizer (urease inhibitor), which temporarily inhibits the action of the urease enzyme to improve the efficiency of urea-containing fertilizers. Given the potential for NBPT residues to be present in milk and tissues of dairy cattle, due diligence is needed to demonstrate the safety of NBPT in urea-based fertilizers used on forages and crops intended for consumption by Holstein dairy cows. This study used controlled dosing of NBPT in capsule form to dairy cattle for 28 d, followed by a 14-d depuration phase to assess the potential for residues to exist in milk and tissues of dairy cattle at exaggerated use levels. Fourteen lactating cows were selected for the dosing and depuration phases of the study, based on health, body weight (BW), and milk production. There were four treatment groups: 0 mg NBPT/kg BW (Control) (n = 2 cows), 1 mg NBPT/kg BW (1×) (n = 3 cows), 3 mg NBPT/kg BW (3×) (n = 3 cows), and 10 mg NBPT/kg/BW (10×) (n = 6 cows); levels were based on maximum tolerable amount of urea that a cow can ingest on a daily basis (1×) and the maximum concentration of NBPT commercially used when treating urea (0.1 wt% NBPT in urea). At the end of the 28-d dosing phase, cows were randomly selected for the 14-d depuration phase of the study (one control and three 10× cows). The results showed no NBPT residue is detectable at all dose levels, except that a residue level was above the lower limit of quantitation in a single milk and subcutaneous fat sample in the highest (10×) treatment group, which represents the level of NBPT that would be theoretically present in 10× the lethal dosing of daily consumable urea to a cow. Overall, the study demonstrated that it is unlikely for NBPT residues to be present in cattle milk or edible tissues or to cause negative effects on animal health under good agricultural practice.
Treerecs: an integrated phylogenetic tool, from sequences to reconciliations
Authors: Comte Nicolas , Morel Benoit , Hasic Damir , Guéguen Laurent , Boussau Bastien , Daubin Vincent , Penel Simon , Scornavacca Celine , Gouy Manolo , Stamatakis Alexandros , Tannier Eric , Parsons David P. 
Published: October 2019

AbstractMotivationGene and species tree reconciliation methods are used to interpret gene trees, root them and correct uncertainties that are due to scarcity of signal in multiple sequence alignments. So far, reconciliation tools have not been integrated in standard phylogenetic software and they either lack performance on certain functions, or usability for biologists.ResultsWe present Treerecs, a phylogenetic software based on duplication-loss reconciliation. Treerecs is simple to install and to use. It is fast and versatile, has a graphic output, and can be used along with methods for phylogenetic inference on multiple alignments like PLL and Seaview.AvailabilityTreerecs is open-source. Its source code (C++, AGPLv3) and manuals are available from https://project.inria.fr/treerecs/Contacteric.tannier@inria.fr or david.parsons@inria.fr
Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses
Authors: Frederiksen Simona D , Wicki-Stordeur Leigh E , Swayne Leigh Anne 
Published: October 2019

ABSTRACTMany neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signalling scaffold is linked to several of these neurological conditions and is an emerging regulator of synaptic development and plasticity; however, its synaptic pathogenic contributions are relatively unexplored. To this end, we explored connections between synaptic neurodevelopmental disorder and neurodegenerative disease susceptibility genes discovered by genome-wide association studies (GWASs), and the neural PANX1 interactome (483 PANX1-interacting proteins identified from mouse Neuro2a cells). To identify shared susceptibility genes, we compared synaptic suggestive GWAS candidate genes amongst autism spectrum disorders, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Next, to further probe PANX1 signalling pathways at the synapse, we used bioinformatics tools to identify PANX1 interactome signalling pathways and protein-protein interaction clusters. To shed light on synaptic disease mechanisms potentially linking PANX1 and these four neurological conditions, we performed additional cross-analyses between gene ontologies enriched for the PANX1 synaptic and disease-susceptibility gene sets. Finally, to explore the regional specificity of synaptic PANX1-neurological conditions connections, we identified brain region-specific elevations of synaptic PANX1 interactome and GWAS candidate gene set transcripts. Our results confirm considerable overlap in risk genes for autism spectrum disorders and schizophrenia and identify potential commonalities in genetic susceptibility for neurodevelopmental disorders and neurodegenerative diseases. Our findings also pinpointed novel putative PANX1 links to synaptic disease-associated pathways, such as regulation of vesicular trafficking and proteostasis, warranting further validation.
High and stable ATP levels prevent aberrant intracellular protein aggregation
Authors: Takaine Masak , Imamura Hiromi , Yoshida Satoshi 
Published: October 2019

ABSTRACTATP at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the significance of this high ATP level under physiological conditions and the mechanisms that maintain ATP remain unclear. We herein demonstrated that AMP-activated protein kinase (AMPK) and adenylate kinase (ADK) cooperated to maintain cellular ATP levels regardless of glucose levels. Single cell imaging of ATP-reduced yeast mutants revealed that ATP levels in these mutants repeatedly underwent stochastic and transient depletion, which induced the cytotoxic aggregation of endogenous proteins and pathogenic proteins, such as huntingtin and α-synuclein. Moreover, pharmacological elevations in ATP levels in an ATP-reduced mutant prevented the accumulation of α-synuclein aggregates and its cytotoxicity. The removal of cytotoxic aggregates depended on proteasomes, and proteasomal activity cooperated with AMPK or ADK to resist proteotoxic stresses. The present study is the first to demonstrate that cellular ATP homeostasis ensures proteostasis and revealed that suppressing the high volatility of cellular ATP levels prevented cytotoxic protein aggregation, implying that AMPK and ADK are important factors that prevent proteinopathies, such as neurodegenerative diseases.
Lysosomal degradation ensures accurate chromosomal segregation to prevent genomic instability
Authors: Almacellas Eugènia , Day Charles , Ambrosio Santiago , Tauler Albert , Mauvezin Caroline 
Published: October 2019

ABSTRACTLysosomes, as primary degradative organelles, are the end-point of different converging pathways including macroautophagy. To date, lysosome function has mainly focused on interphase cells, while their role during mitosis remains controversial. Mitosis dictates the faithful transmission of genetic material among generations, and perturbations of mitotic division lead to chromosomal instability, a hallmark of cancer. Heretofore, correct mitotic progression relies on the orchestrated degradation of mitotic factors, which was mainly attributed to ubiquitin-triggered proteasome-dependent degradation. Here, we show that mitotic transition does not only rely on proteasome-dependent degradation, as impairment of lysosomes increases mitotic timing and leads to mitotic errors, thus promoting chromosomal instability. Furthermore, we identified several putative lysosomal targets in mitotic cells. Among them, WAPL, a cohesin regulatory protein, emerged as a novel p62-interacting protein for targeted lysosomal degradation. Finally, we characterized an atypical nuclear phenotype, the toroidal nucleus, as a novel biomarker for genotoxic screenings. Our results establish lysosome-dependent degradation as an essential event to prevent genomic instability.
Rutin, a Natural Inhibitor of IGPD Protein, Inhibits the Biofilm Formation inStaphylococcus xylosusATCC700404
Authors: Bello-Onaghise God’spower , Xiaoxu Xing , Yonghui Zhou , Qianwei Qu , Wenqiang Cui , Yang Tang , Xingru Chen , Jinpeng Wang , Li Yan-Hua 
Published: October 2019

ABSTRACTThe biofilm of bacteria plays an important role in antibiotic resistance and chronic infection. Thus, in order to solve the problem of resistant bacteria, it is very important to find new drugs that can inhibit the formation of biofilms. In recent years, researchers have shifted their attention to natural products. As a flavonoid, rutin has been reported to have a variety of biological activities, interestingly, in this study, the inhibitory effect of rutin on the biofilm ofStaphylococcus xylosuswas investigated. We confirmed that rutin could effectively inhibit the biofilm formation ofS. xylosus, then, for the sake of discussion on how it interferes with the biofilm formation, the interaction between rutin and imidazolyl phosphate dehydratase (IGPD) which has been identified as the key enzyme that plays a vital role in the process of biofilm formation was analyzed by molecular docking, the results showed that rutin had a strong affinity with IGPD, it occupied the hydrophobic cavity of the active center forming four hydrogen bonds and many other interactions. In addition, we proved that rutin was able to combine with IGPD using SPR technique. Therefore, we determined the enzyme activity and histidine content of IGPD, the result indicated that rutin could simultaneously inhibit the activity of IGPD and abrogate the synthesis of histidine. Interestingly, thehisBgene encoding for IGPD and IGPD inS. xylosuswere also significantly inhibited when the bacterial culture was treated with rutin. Taken together, the results have provided evidence that rutin is a natural drug that has the ability to interfere with the formation of biofilm inS. xylosus. It is therefore a potential enzyme inhibitor of IGPD.Author’s SummaryStaphylococcus xylosushas been isolated from a variety of infections, and the biofilm formed byS. xylosuscan help the bacteria evade the immune system of the host and cause chronic infections. Here, we dealt with this menace by establishing a highly effective drug with the ability to interfere with the process involved in the formation of biofilm inS. xylosus. IGPD has been reported to be directly involved in the formation of biofilm inStaphylococcus xylosusand it is known to be present in a variety of microorganisms. Based on this study, we developed a drug therapy targeting IGPD and at the same time interfere with the formation of biofilm inS. xylosus
The Effect of Foreign Demand on Residential Property Prices: Evidence from Australia
Authors: Wokker Chris , Swieringa John 
Published: October 2019

AbstractThis study estimates the impact of foreign demand for Australian residential real estate on property prices. Using postcode‐level administrative data and fixed‐effects regression techniques we find a positive relationship between foreign investment approvals and price growth. Our analysis suggests that, on average, foreign investment contributed between $80 and $122 to quarterly price growth in Sydney and Melbourne between July 2010 and March 2015. This is a small proportion of the increase in property prices over the period.
Progressive Politics in a Changing World: Challenging the Fallacies of Blue Labour
Authors: Bloomfield Jon 
Published: October 2019

AbstractIn Britain and across Europe, the social alliances that sustained progressive politics for a century are disintegrating. The financial crisis of 2007–8 showed that Labour and its ‘third way’ European followers had got the economics of modern capitalism wrong. With the mainstream left compromised, it has been the nationalist right that has benefitted, re‐defining politics around issues of nation, culture and identity. What is surprising is the number of influential voices across the centre and left of politics who have accepted much of this far‐right analysis and adopted its language and terminology. These trends, especially post‐Brexit, have crystallised in the UK around the label of ‘Blue Labour’. This article examines the fallacies and flaws of the Blue Labour tendency in four key areas—class, economy, family and race—and suggests alternative ways forward, which seek to forge rather than disrupt alliances between the working class and new social movements.
Volume of ropivacaine 0.2% and sciatic nerve block duration: A randomized, blinded trial in healthy volunteers
Authors: Christiansen Claus B. , Madsen Mikkel H. , Rothe Christian , Andreasen Asger M. , Lundstrøm Lars H. , Lange Kai H. W. 
Published: October 2019

BackgroundSciatic nerve blocks are used for many orthopaedic procedures on the knee, lower leg, foot and ankle. However, as nerve block durations vary considerably, the timing of supplemental analgesia is challenging. Therefore, knowledge on the effect of local anaesthetic (LA) dose on block duration is important to outweigh the benefits of increasing LA dose against the risk of LA systemic toxicity. In this randomized, double‐blind trial, we aimed to explore the relationship between the volume of ropivacaine 0.2% and sciatic nerve block duration. We hypothesized that increasing LA volume would prolong block duration.MethodsWe randomized 60 healthy volunteers to receive one of five volumes of ropivacaine 0.2%: 5, 10, 15, 20, or 30 mL. We used an ultrasound‐guided, catheter‐based technique targeting the sciatic nerve in the infragluteal region. The primary outcome was sensory block duration defined as the time of insensitivity to a cold stimulus. Intergroup differences were tested using one‐way ANOVA.ResultsMean (SD) sensory block durations for the tibial nerve (TN) with increasing volume were: 9.3 hours (1.7), 10.4 hours (1.6), 9.7 hours (2.9), 10.7 hours (2.8) and 9.9 hours (2.6). Mean (SD) sensory block durations for the common peroneal nerve (CPN) were: 10.6 hours (2.7), 11.9 hours (1.5), 11.0 hours (3.3), 13.2 hours (3.7), and 13.5 hours (6.1). There were no intergroup differences (P = .67 [TN]; P = .25 [CPN]).ConclusionWe found no effect of increasing the volume of ropivacaine 0.2% from 5 to 30 mL on sensory sciatic nerve block duration.
Exercise‐induced attenuation of treatment side‐effects in patients with newly diagnosed prostate cancer beginning androgen‐deprivation therapy: a randomised controlled trial
Authors: Ndjavera Wilphard , Orange Samuel T. , O'Doherty Alasdair F. , Leicht Anthony S. , Rochester Mark , Mills Robert , Saxton John M. 
Published: October 2019

Objectives(i) To assess whether exercise training attenuates the adverse effects of treatment in patients with newly diagnosed prostate cancer beginning androgen‐deprivation therapy (ADT), and (ii) to examine whether exercise‐induced improvements are sustained after the withdrawal of supervised exercise.Patients and MethodsIn all, 50 patients with prostate cancer scheduled for ADT were randomised to an exercise group (n = 24) or a control group (n = 26). The exercise group completed 3 months of supervised aerobic and resistance exercise training (twice a week for 60 min), followed by 3 months of self‐directed exercise. Outcomes were assessed at baseline, 3‐ and 6‐months. The primary outcome was difference in fat mass at 3‐months. Secondary outcomes included: fat‐free mass, cardiopulmonary exercise testing variables, QRISK®2 (ClinRisk Ltd, Leeds, UK) score, anthropometry, blood‐borne biomarkers, fatigue, and quality of life (QoL).ResultsAt 3‐months, exercise training prevented adverse changes in peak O2 uptake (1.9 mL/kg/min, P = 0.038), ventilatory threshold (1.7 mL/kg/min, P = 0.013), O2 uptake efficiency slope (0.21, P = 0.005), and fatigue (between‐group difference in Functional Assessment of Chronic Illness Therapy‐Fatigue score of 4.5 points, P = 0.024) compared with controls. After the supervised exercise was withdrawn, the differences in cardiopulmonary fitness and fatigue were not sustained, but the exercise group showed significantly better QoL (Functional Assessment of Cancer Therapy‐Prostate difference of 8.5 points, P = 0.034) and a reduced QRISK2 score (−2.9%, P = 0.041) compared to controls.ConclusionA short‐term programme of supervised exercise in patients with prostate cancer beginning ADT results in sustained improvements in QoL and cardiovascular events risk profile.
Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives
Authors: Svärd A , Roos Ljungberg K , Brink M , Martinsson K , Sjöwall C , Rantapää Dahlqvist S , Kastbom A 
Published: October 2019

Summary
The aim of this study was to evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and immunoglobulin (Ig)A ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first-degree relatives (FDRs). Patients with RA (n = 194) and first-degree relatives unaffected by RA (n = 191) were recruited for analysis of secretory antibodies to second-generation cyclic citrullinated peptides (anti-CCP) in plasma. From a subpopulation (25 RA patients, 21 first-degree relatives and 11 controls), saliva samples were obtained for IgA anti-CCP analysis. The presence of secretory ACPA was compared between subject categories, and related to genetic and environmental risk factors. Secretory ACPA occurred in 37 (19%) plasma samples from patients with RA, but only in two (1%) of FDRs. IgA ACPA in saliva was found in three of 25 (12%) patients with RA, but not in any of the 21 FDRs (&lt; 5%). No significant associations were seen between the presence of secretory ACPA and SE or smoking, either among RA patients or among FDRs. Despite occurring in 19% of RA plasma, secretory ACPA was rare in both saliva and plasma among FDRs, even among those positive for conventional ACPA of non-mucosal origin. Longitudinal studies are warranted to determine whether circulating secretory ACPA occurs before or in parallel with the development of clinical arthritis.
Datafication, value and power in developing countries: Big data in two Indian public service organizations
Authors: Heeks Richard , Rakesh Vanya , Sengupta Ritam , Chattapadhyay Sumandro , Foster Christopher 
Published: October 2019

AbstractMotivationDatafication—the growing presence, use and impact of data in social processes—is spreading to all sectors in developing countries. But, to date, there are few analyses of real‐world experiences of datafication in developing country organizations.PurposeWe address this knowledge gap by analysing evidence of big data in practice in relation to three key issues: implementation, value and power.Approach and methodsUsing interview, observation and documentary sources, we analyse the implementation and impact of big data systems in Indian electricity and transport public sector organizations.FindingsBig data systems have been much slower to implement than anticipated, and the article exposes the nature and scale of the implementation challenge facing such systems. These are already delivering value for some managers within public service organizations but are, as yet, more operational than strategic and incremental not transformative. Big data systems are facilitating a shift in power from the public sector to the private sector, and from labour and middle management to panopticon‐type control by central managers. Big data intersects with politics especially around the imaginaries of wider stakeholders, changing their view of the financial and political issues that technology can address.Policy implicationsPolicy‐makers and practitioners can better understand and plan for big data in development using three frameworks presented in the article: information value chain, decision pyramid, and big data–power model. These expose key issues of implementation, organizational value and power that must be incorporated into big data policy and projects. Benefits of datafication have been largely restricted to senior managers, private contractors and some politicians. To spread these to other stakeholders, including workers and citizens, action must be taken to address both practical and political issues arising in the datafication of development.
A model of emotional stress‐induced binge eating in female mice with no history of food restriction
Authors: Anversa Roberta G. , Campbell Erin J. , Ch'ng Sarah S. , Gogos Andrea , Lawrence Andrew J. , Brown Robyn M. 
Published: October 2019

AbstractOvereating is a major contributing factor to obesity and related health complications. For women, in particular, negative emotions such as stress strongly influence eating behavior and bingeing episodes. Modeling this type of binge eating in rodents presents challenges: firstly, stress‐induced anorexia is commonly observed in rodents therefore a mild stressor is required in order to observe an orexigenic effect. Second, many studies report using calorie restriction to observe the required behavior; yet this does not necessarily reflect the human condition. Thus, the aim of this study was to develop a model of emotional stress‐induced bingeing independent of caloric restriction. Female and male C57BL/6J mice were divided into ad libitum (n = 20 per sex) and food‐restricted (n = 20 per sex) groups which were both further split into a control group and a group exposed to frustration stress (n = 10 per group). All mice were provided intermittent access to a highly palatable food in 2 cycles. At the end of each cycle the stress group was subjected to a 15‐minute frustration episode where highly palatable food was within the home cage but inaccessible. Both groups were then given free access for 15 minutes. Frustrated female mice from the ad libitum displayed binge‐like behavior compared with controls (P = .0001). Notably, this behavior was absent in males. Ovariectomy had no impact on binge‐like behavior. Collectively, these data validate a novel model of emotional stress‐induced binge eating specific to female mice which does not require caloric restriction and is not driven by ovarian hormones.