bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-neglect and safeguarding adult reviews: towards a model of understanding facilitators and barriers to best practice
Authors: Preston-Shoot Michael 
Published: August 2019

Purpose
The purpose of this paper is twofold: first, to update the core data set of self-neglect safeguarding adult reviews (SARs) and accompanying thematic analysis; second, to draw together the learning available from this data set of reviews to propose a model of good practice that can be used as the basis for subsequent SARs.

Design/methodology/approach
Further published reviews are added to the core data set from the websites of Safeguarding Adults Boards (SABs). Thematic analysis is updated using the four domains employed previously. A sufficient number of reviews have been performed from which to construct an evidence-based model of good practice. A framework is presented with the proposition that this can be used as a proportional methodology for further SARs where self-neglect is in focus.

Findings
Familiar findings emerge from the thematic analysis. This level of analysis, constructed over time and across reviews, enables a framework to be developed that pulls together the findings into a model of good practice with individuals who self-neglect and for policies and procedures with which to support those practitioners involved in such cases. This framework can then be used as an evidence-based model with which to review new cases where SARs are commissioned.

Research limitations/implications
The national database of reviews commissioned by SABs is incomplete and does not contain many of the SARs reported in this evolving data set. The Care Act 2014 does not require publication of reports but only a summary of findings and recommendations in SAB annual reports. It is possible, therefore, that this data set is also incomplete. Drawing together the findings from the reviews nonetheless enables conclusions to be proposed about the components of effective practice, and effective policy and organisational arrangements for practice. Future reviews can then explore what enables such effective to be achieved and what barriers obstruct the realisation of effective practice.

Practical implications
Answering the question “why” is a significant challenge for SARs. A framework is presented here, drawn from research on SARs featuring self-neglect, that enables those involved in reviews to explore the enablers and barriers with respect to an evidence-based model of effective practice. The framework introduces explicitly research and review evidence into the review process.

Originality/value
The paper extends the thematic analysis of available reviews that focus on work with adults who self-neglect, further building on the evidence base for practice. The paper also proposes a new approach to SARs by using the findings and recommendations systematically within a framework designed to answer “why” questions – what promotes and what obstructs effective practice.
The impact of cryptocurrencies market development on banks’ deposits variability in the GCC region
Authors: Othman Anwar Hasan Abdullah , Alhabshi Syed Musa , Kassim Salina , Sharofiddin Ashurov 
Published: August 2019

PurposeWith the continuing development of the financial technology revolution, a better understanding of bank deposits variability has become necessary for bank management and policymakers, especially central banks. This is because the novel innovations of cryptocurrencies operate beyond the realm of the banking system, which may impact the performance of banks and their deposits variability. This study aims to investigate the long- and short-run effects of cryptocurrencies’ market capitalization development on the banks’ deposit variability in the Gulf Cooperation Council (GCC) region.Design/methodology/approachIn this study, the Johansen–Juselius (1990) cointegration test with vector error correction model was applied to examine the long-run relationships, while the Engle and Granger (1987) and the Granger (1969) causality tests were used to detect causal relationships in the short term.FindingsThe findings of Johansen–Juselius cointegration test indicate that the banks’ deposits variability in all six states of the Gulf region share negative long-run equilibrium association with the development of global cryptocurrencies market capitalization, but with different statistically significant levels. For the short-run analysis, the study found that the development of cryptocurrencies market capitalization has significant unidirectional causal effects on bank deposits variabilities in only four states, namely, UAE, Qatar, Kuwait and Bahrain. The findings of the study therefore suggest that to eradicate the effects of cryptocurrencies industry and its threats to the banking industry, banks in GCC region are encouraged to either consider cryptocurrencies as an alternative investment asset for their portfolio investment diversification strategies or adopt the blockchain technology in their operation system to facilitate their customers with low transaction cost, high level of security and ease of use and real-time settlement.Research limitations/implicationsThe empirical findings of the study will provide valuable input for policymakers, especially central banks and bank managements, to evaluate the current situation and the threats of the cryptocurrencies market growth and its effect on the banking industry’s performance, future survival and their deposits variability for better regulation and policy planning and investment strategies.Originality/valueThis is a pioneering study that empirically explores the phenomenon of bank deposits variability as a consequence of expansion in cryptocurrencies market capitalization, where the findings proved evidence of a drastic decline in banks’ deposits size due to the substantial growth in cryptocurrencies market capitalization.
Relational fragility, development and an emerging self: service user views of engaging in an IIRMS in the OPD pathway
Authors: Ryan Sue , Gordon Frances , Gordon Neil 
Published: August 2019

Purpose
The purpose of this paper is to gain an in-depth view into how participants perceived their experience of engaging in an enhanced Intensive Intervention and Risk Management Service (IIRMS), which is a part of the Offender Personality Disorder (OPD) pathway based within the community.

Design/methodology/approach
Five participants were interviewed. They were at different points of engagement with the service. Interviews were taped, transcribed and analysed using the grounded theory methodology.

Findings
Participants were able to provide in-depth reflections about their experiences at the service. The main issues centred upon “managing fragile relationships” and “an emerging self”. Subcategories linked to managing fragile relationships were: “letting people in and keeping them away”; “surviving the ruptures”; and “treating me like a person”. Subcategories linked to an emerging self were: “readiness to change” and “making new connections”.

Research limitations/implications
This study focused upon one enhanced IIRMS and findings are not necessarily generalisable to other services within the OPD pathway, although themes are likely to resonate for those leaving custody with complex interpersonal difficulties.

Practical implications
This study has provided access to participants’ perspectives on engaging with an IIRMS. Many factors impact upon the individual’s journey, which is central to the relational approach underpinning the pathway.

Originality/value
The findings have important messages for service providers and commissioners and crucially service user perspectives have been obtained that are integral to future development of the OPD pathway. The findings are also relevant for released prisoners attempting to reintegrate within the community.
Effect of medical thoracoscopy‐guided intrapleural docetaxel therapy to manage malignant pleural effusion in patients with non‐small cell lung cancer: A pilot study
Authors: Choi Myeong Geun , Park Sojung , Oh Dong Kyu , Kim Hyeong Ryul , Lee Geun Dong , Lee Jae Cheol , Choi Chang‐Min , Ji Wonjun 
Published: August 2019

BackgroundAlthough chemical pleurodesis is a useful treatment option for malignant pleural effusion, little is known about the effects of intrapleural docetaxel therapy.ObjectivesThis study aimed to evaluate the effects of medical thoracoscopy‐guided intrapleural docetaxel therapy in patients with lung cancer.MethodsPatients with lung cancer who diagnosed malignant pleural effusion were enrolled in this single‐center prospective pilot study. The clinical response and toxicity were evaluated at two, six and 12 weeks post‐treatment.ResultsMedical thoracoscopy‐guided intrapleural docetaxel therapy was conducted in four patients between June 2016 and August 2017. The control rate of malignant pleural effusion was 100% (4/4), and the progression‐free duration of effusion was 527 ± 109 days. No serious adverse events were observed, but only mild‐to‐moderate adverse events were observed and well controlled by conservative management. Although the overall quality of life assessed using questionnaires did not show significant improvement, symptom burden due to dyspnea was significantly improved.ConclusionsIntrapleural docetaxel therapy with medical thoracoscopy showed good clinical responses, relieving dyspnea symptoms and providing tolerable safety profiles in patients with non‐small cell lung cancer (NSCLC) with malignant pleural effusion. A further prospective trial is warranted to evaluate the clinical effects of intrapleural docetaxel therapy in order to compare it with other treatment modalities.
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival
Authors: Chen Liang‐Jian , Yang Zhi‐Xia , Wang Yang , Du Lei , Li Yan‐Ru , Zhang Na‐Na , Gao Wen‐Yi , Peng Rui‐Rui , Zhu Feng‐Yu , Wang Li‐Li , Li Cong‐Rong , Li Jian‐Min , Wang Fu‐Qiang , Sun Qing‐Yuan , Zhang Dong 
Published: August 2019

AbstractProlonging the ovarian lifespan is attractive and challenging. An optimal clinical strategy must be safe, long‐acting, simple, and economical. Allotransplantation of brown adipose tissue (BAT), which is most abundant and robust in infants, has been utilized to treat various mouse models of human disease. Could we use BAT to prolong the ovarian lifespan of aging mice? Could we try BAT xenotransplantation to alleviate the clinical need for allogeneic BAT due to the lack of voluntary infant donors? In the current study, we found that a single rat‐to‐mouse (RTM) BAT xenotransplantation did not cause systemic immune rejection but did significantly increase the fertility of mice and was effective for more than 5 months (equivalent to 10 years in humans). Next, we did a series of analysis including follicle counting; AMH level; estrous cycle; mTOR activity; GDF9, BMP15, LHR, Sirt1, and Cyp19a level; ROS and annexin V level; IL6 and adiponectin level; biochemical blood indices; body temperature; transcriptome; and DNA methylation studies. From these, we proposed that rat BAT xenotransplantation rescued multiple indices indicative of follicle and oocyte quality; rat BAT also improved the metabolism and general health of the aging mice; and transcriptional and epigenetic (DNA methylation) improvement in F0 mice could benefit F1 mice; and multiple KEGG pathways and GO classified biological processes the differentially expressed genes (DEGs) or differentially methylated regions (DMRs) involved were identical between F0 and F1. This study could be a helpful reference for clinical BAT xenotransplantation from close human relatives to the woman.
Accommodation payment plans in residential aged care: The impact of consumer choice
Authors: Abiona Olukorede , Yu Serena , Woods Mike , van Gool Kees 
Published: August 2019

AbstractObjectiveTo examine changes in accommodation payments to residential aged care facilities following the introduction of consumer choice reforms in 2014. These reforms have allowed residents to choose between making lump sum refundable deposits and/or rental‐style payments.MethodsQuantitative analysis was undertaken for facility‐level quarterly data of 136 separate facilities, which were operated by six providers over the period under study.ResultsWhile the total pool of payments has grown strongly, consumers have increasingly favoured rental‐style payments over lump sum refundable deposits.ConclusionConsumer choice has changed the landscape of accommodation payment receipts in the provision of residential aged care services. Greater understanding is needed on how consumer preferences impact on the financial risk borne by providers and their ability to invest in future capacity.
Impact of a major sporting event on local orthopaedic service provision: Commonwealth Games 2018, Gold Coast, Australia
Authors: Quinn Jonathan , Fairbairn William , Tan Ezekiel S. L. 
Published: August 2019

BackgroundThe Gold Coast (Queensland, Australia) held the 2018 Commonwealth Games. Previous studies have focussed on the socio‐economic and employment impact of hosting a major sporting event; however, there is limited research available about the provision of medical recourses required of the host city.MethodsTwelve weeks of data were retrospectively collected from the local health service to quantify the orthopaedic department workload for the period surrounding the 2018 Commonwealth Games. Data collected included referrals to Orthopaedic Fracture Outpatient clinic, theatre cases – emergency and category 1 (scheduled trauma) performed, and entries made into electronic medical records by the on‐call orthopaedic staff.ResultsA statistically significant increase was found for theatre cases performed during the Commonwealth Games (86 versus 71 cases per week, P = 0.033, 95% confidence interval 1.46–27.5). We found no statistically significant increase in Fracture Outpatient Clinic referrals or medical record entries between peri‐games and games periods (P = 0.149 and 0.699, respectively).ConclusionBased on our experience, orthopaedic departments should plan for an increase in operative intervention requirements of at least 20%, in consultation with other local services. Strategic use of pre‐existing resources and staff may be sufficient to address the increased workload during the event period.
The problem of imposing risk and the procedural dimension of stakeholder management
Authors: Cohen Marc A. 
Published: August 2019

AbstractThe case Caprica Energy and Its Choices concerns a fictionalized energy corporation choosing between three potential drilling sites. According to the published Teaching Note, the case is an exercise in the stakeholder approach to business: it requires balancing profit considerations with potential harm to those who live near those drilling sites. Though unintended, the case raises a further question not addressed in the case or in the Teaching Note: what gives Caprica Energy the right to impose risk on members of the communities surrounding its drilling sites? The first section of the present article argues that, in such cases, management can only justify imposing risk on the local community by securing those stakeholders' consent. The second section outlines the implications for stakeholder theory and stakeholder management. The third section outlines one connection between this material and recent literature on the imposition of risk and moral theory; that section offers an account of what make this particular instance of imposing risk morally problematic, with reference to the directedness of the imposition.
The relationship between insecure attachment and paranoia in psychosis: A systematic literature review
Authors: Lavin Rachel , Bucci Sandra , Varese Filippo , Berry Katherine 
Published: August 2019

ObjectivesParanoia is a key symptom in psychosis and associated with a range of poor outcomes. Earlier life experiences increase vulnerability to paranoid thinking, and attachment theory has been proposed as a key model in explaining this causal pathway. Previous reviews highlight evidence of associations between insecure attachment styles and overall severity of psychotic symptoms. Studies report on associations between insecure attachment and paranoia, but to date, this literature has not been adequately synthesized. The aim of the current review was to report the strength and consistency of associations between paranoia and insecure attachment across published studies, and provide systematic appraisal of study quality.MethodWe carried out a systematic review of electronic databases using search terms to capture concepts of adult attachment, paranoia, and psychosis. We pre‐registered the review protocol and followed PRISMA guidelines.ResultsSignificant associations were reported in 11 out of 12 studies between an insecure attachment and paranoia, with associations remaining significant in studies that controlled for comorbid symptoms. The strongest, most commonly reported relationship was between an anxious attachment style and paranoia.ConclusionsThe findings support the proposed role of attachment insecurity in the development and maintenance of paranoia in psychosis and highlight the need to address insecure attachment representations in the treatment of paranoia.Practitioner points

There is consistent evidence of associations between insecure attachment style and paranoia.

Insecure anxious attachment is more consistently associated with paranoia than an insecure avoidant attachment.

Associations between attachment and paranoia remain significant when key confounders are controlled for in the analyses.

Interventions that address insecure attachment representations and promote a more secure attachment are likely to help reduce paranoia.
Emergency response to radiological and nuclear accidents and incidents
Authors: Gale Robert P. , Armitage James O. , Hashmi Shahrukh K. 
Published: August 2019

SummaryBone marrow damage is an important consequence of exposure to acute high‐dose whole‐body radiation. As such, haematologists can play an important role in managing this complication. However, these accident and incident scenarios are complex and often involve injuries to other organs and tissues from heat, projectiles and chemicals. In the case of a large‐scale event there will likely be severe infrastructure disruptions and injury or death to medical personnel. Accurate estimates of dose and uniformity of exposure are needed to intelligently direct appropriate interventions, which range from antibiotics, antifungals and anti‐virus drugs, molecularly‐cloned haematopoietic growth factors and, in rare instances, haematopoietic cell transplants. These therapies are ones that haematologists often use in the context of anti‐cancer therapy, especially therapy of haematological cancers like leukaemia. However, most haematologists have little knowledge of radiation biology and should consider updating this aspect of their expertise in continuing medical education. As in other areas of medicine, prevention is better than cure and haematologists should be active in decreasing risks of a nuclear war.
Complaints‐Based Entrepreneurialism: Worker Experiences of the Employment Standards Complaints Process in Ontario, Canada
Authors: Mirchandani Kiran , Hande Mary Jean , Condratto Shelley 
Published: August 2019

AbstractIn Ontario, workers who face unfair working conditions have the option of filing an official complaint with the Ministry of Labour. Complaints making is characterized as a widely available, easily accessible, and free‐of‐cost avenue for workers who may have experienced a violation of the law. However, interviews with Ontario workers who have filed complaints tell a different story. This paper is based on a community‐university project on the enforcement of the Employment Standards Act in Ontario. We draw on 36 interviews with workers employed in precarious jobs in Sudbury, Toronto, and Windsor, who filed complaints to the Ministry. Workers characterize the complaints process as rife with bureaucratic complexity, risk, and unsuccessful payouts. Their experiences shed light on the efficacy of complaint‐based approaches that are often promoted as a form of “bottom‐up” enforcement of employment standards (ES). We demonstrate that the current ES complaints system requires workers to enact neoliberal entrepreneurialism (rather than agentic or collective entrepreneurialism) creating a highly stressful, enormously time‐consuming, and demoralizing experience. We document the increasingly individualized and contradictory avenues through which workers must act as entrepreneurs to navigate and self‐advocate when their rights have been violated. We argue that the current complaint processes limit the potentially empowering impact of this strategy.
Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial
Authors: Shimizu Yasuhiro , Yoshikawa Toshiaki , Kojima Takashi , Shoda Kayoko , Nosaka Kazuto , Mizuno Shoichi , Wada Satoshi , Fujimoto Yuki , Sasada Tetsuro , Kohashi Kenichi , Bando Hideaki , Endo Itaru , Nakatsura Tetsuya 
Published: August 2019

AbstractHeat shock protein 105 (HSP105) is overexpressed in many cancers, including colorectal cancer (CRC) and esophageal cancer (EC). We carried out a phase I clinical trial of HLA‐A24‐ and HLA‐A2‐restricted HSP105 peptide vaccines in patients with CRC or EC. In this additional study of the trial, we examined the immunological efficacy of the novel vaccine. Thirty patients with advanced CRC or EC underwent HSP105 peptide vaccination. Immunological responses were evaluated by ex vivo and in vitro γ‐interferon enzyme‐linked immunospot assays and their correlation with patients’ prognosis was analyzed. The HSP105 peptide vaccines induced peptide‐specific CTLs in 15 of 30 patients. Among HLA‐A24 patients (n = 15), 7 showed induction of CTLs only ex vivo, whereas among HLA‐A2 patients (n = 15), 4 showed the induction ex vivo and 6 in vitro. Heat shock protein 105‐specific CTL induction correlated with suppression of cancer progression and was revealed as a potential predictive biomarker for progression‐free survival (P = .008; hazard ratio = 3.03; 95% confidence interval, 1.34‐6.85) and overall survival (P = .025; hazard ratio = 2.72; 95% confidence interval, 1.13‐6.52). Production of cytokines by HSP105 peptide‐specific CTLs was observed at the injection sites (skin) and tumor tissues, suggesting that HSP105‐specific CTLs not only accumulated at vaccination sites but also infiltrated tumors. Furthermore, we established 2 HSP105 peptide‐specific CTL clones, which showed HSP105‐specific cytokine secretion and cytotoxicity. Our results suggest that the HSP105 peptide vaccine could induce immunological effects in cancer patients and improve their prognosis.