bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain Susceptibility Phenotypes in Those Free of Knee Pain With or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Authors: Carlesso Lisa C. , Segal Neil A. , Frey‐Law Laura , Zhang Yuqing , Na Lu , Nevitt Michael , Lewis Core E. , Neogi Tuhina 
Published: October 2018

ObjectiveIt is not clear why some individuals develop pain with knee osteoarthritis (OA). We undertook this study to identify pain susceptibility phenotypes (PSPs) and their relationship to incident persistent knee pain (PKP) 2 years later.MethodsWe identified individuals free of PKP from the Multicenter Osteoarthritis Study, a longitudinal cohort of older adults with or at risk of knee OA. Latent class analysis was used to determine PSPs that may contribute to development of PKP apart from structural pathology. These included widespread pain, poor sleep, and psychological factors as well as pressure pain threshold and temporal summation (TS) as determined by quantitative sensory testing (QST). We used logistic regression to evaluate the association of sociodemographic factors with PSPs and the relationship of PSPs to the development of PKP over 2 years.ResultsA total of 852 participants were included (mean age 67 years, body mass index 29.5 kg/m2, 55% women). Four PSPs were identified, primarily characterized by varying proportions (low/absent, moderate, or high) of the presence of pressure pain sensitivity and of facilitated TS, reflecting different measures of sensitization. Subjects in the PSP with a high proportion of pressure pain sensitivity and a moderate proportion of facilitated TS were twice as likely to develop incident PKP over 2 years (odds ratio 1.98 [95% confidence interval 1.07–3.68]) compared with subjects in the PSP having a low proportion of sensitization by both measures.ConclusionFour PSPs were identified, 3 of which were predominated by QST evidence of sensitization and 1 of which was associated with developing PKP 2 years later. Prevention or amelioration of sensitization may be a novel approach to preventing onset of PKP in OA.
Sustainability core values and sustainability risk management: Moderating effects of top management commitment and stakeholder pressure
Authors: Wijethilake Chaminda , Lama Tek 
Published: October 2018

AbstractThis study examines the moderating effects of top management commitment and stakeholder pressure on the relationship between sustainability core values and sustainability risk management (SRM). We collected survey data from senior management in both local and multinational organisations in Sri Lanka. Data were analysed via partial least squares structural equation modelling. We find that the extent to which organisations integrate sustainability into core values has a significant positive impact on SRM. As predicted, top management commitment to sustainability positively moderates the relationship. However, contrary to our expectation, stakeholder pressure for sustainability shows a negative effect on the relationship. We add novel insights into the strategic conformity of internal and external sustainability drivers on SRM.
Strong impact of sulfotransferases on DNA adduct formation by 4‐aminobiphenyl in bladder and liver in mice
Authors: Li Yun , Chen Zhidan , Paonessa Joseph D. , Meinl Walter , Bhattacharya Arup , Glatt Hansruedi , Vouros Paul , Zhang Yuesheng 
Published: October 2018

AbstractBladder cancer risk is 3‐4 times higher in men than women, but the reason is poorly understood. In mice, male bladder is also more susceptible than female bladder to 4‐aminobiphenyl (ABP), a major human bladder carcinogen; however, female liver is more susceptible than male liver to ABP. We investigated the role of sulfotransferase (Sult) in gender‐related bladder and liver susceptibility to ABP. Sulfation reactions of aromatic amine bladder carcinogens catalyzed by Sult may generate highly unstable and toxic metabolites. Therefore, liver Sult may decrease bladder exposure to carcinogens by promoting their toxic reactions in the liver. Notably, the expression of several liver Sults is suppressed by androgen in male mice. Here, we show that two Sults are critical for gender‐related bladder susceptibility to ABP in mice. We measured tissue level of N‐(deoxyguanosin‐8‐yl)‐4‐aminobiphenyl (dG‐C8‐ABP), a principal ABP‐DNA adduct, as readout of tissue susceptibility to ABP. We identified Sutl1a1 and to a lesser extent Sult1d1 as Sults that promote dG‐C8‐ABP formation in hepatic cells. In mice, gender gap in bladder susceptibility to ABP was narrowed by knocking out Sult1a1 and was almost totally eliminated by knocking out both Sutl1a1 and Sult1d1. This was accompanied by dramatic decrease in ABP genotoxicity in the liver (>97%). These results show the strong impact of the Sults on bladder and liver susceptibility to a human carcinogen. Because liver expression of both Sult1a1 and Sutl1d1 is suppressed by androgen in male mice, our results suggest that androgen renders bladder more exposed to ABP in male mice by suppressing Sult‐mediated ABP metabolism in liver, which increases bladder delivery of carcinogenic metabolites.
Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need To Protect DNA against Destruction in Nucleosome Core Particles Containing Abasic Sites
Authors: Yang Kun , Greenberg Marc M. 
Published: October 2018

AbstractAbasic sites (AP) are produced 10 000 times per day in a single cell. Strand cleavage at AP is accelerated ≈100‐fold within a nucleosome core particle (NCP) compared to free DNA. The lysine‐rich N‐terminal tails of histone proteins catalyze single‐strand breaks through a mechanism used by base‐excision‐repair enzymes, despite the general dearth of glutamic acid, aspartic acid, and histidine—the amino acids that are typically responsible for deprotonation of Schiff base intermediates. Incorporating glutamic acid, aspartic acid, or histidine proximal to lysine residues in histone N‐terminal tails increases AP reactivity as much as sixfold. The rate acceleration is due to more facile DNA cleavage of Schiff‐base intermediates. These observations raise the possibility that histone proteins could have evolved to minimize the presence of histidine, glutamic acid, and aspartic acid in their lysine‐rich N‐terminal tails to guard against enhancing the toxic effects of DNA damage.
π‐Allylpalladium Species in Micelles of FI‐750‐M for Sustainable and General Suzuki‐Miyaura Couplings of Unactivated Quinoline Systems in Water
Authors: Handa Sachin , Ibrahim Faisal , Ansari Tharique N. , Gallou Fabrice 
Published: October 2018

AbstractThe front cover artwork for issue 19/2018 is a collaboration between the University of Louisville (USA) and Novartis Pharmaceuticals at Basel (Switzerland). The image illustrates the high‐stability and recyclability of π‐allyl palladium in the micelles of recently designed amphiphile FI‐750‐M to conduct cross‐couplings of unactivated quinolines in water under mild conditions. See the Full Paper itself at https://doi.org/10.1002/cctc.201800958.
Organic Dyes based on Tetraaryl‐1,4‐dihydropyrrolo‐[3,2‐b]pyrroles for Photovoltaic and Photocatalysis Applications with the Suppressed Electron Recombination
Authors: Wang Jinfeng , Chai Zhaofei , Liu Siwei , Fang Manman , Chang Kai , Han Mengmeng , Hong Li , Han Hongwei , Li Qianqian , Li Zhen 
Published: October 2018

AbstractA tetraaryl‐1,4‐dihydropyrrolo‐[3,2‐b]pyrroles (TAPP) moiety with the combination of two pyrrole rings and four phenyl moieties demonstrated strong electron‐donating ability and nonplanar configuration simultaneously. Once incorporated into the organic dyes as a novel electron donor, it was beneficial for the enhancement of light‐harvesting ability and suppression of electron recombination in the photovoltaic and photocatalysis systems. With the linkage of tunable conjugated bridges and electron acceptor, the corresponding organic dyes exhibited improved photovoltaic performance in dye‐sensitized solar cells and facilitated photocatalytic hydrogen generation with a highest turnover number (TON) of 4337. Through the detailed investigation of relationship between molecular structures and photovoltaic/photocatalysis property, the connection and difference in molecular design for these two systems are well explained, with the aim to promote the application of dye‐sensitized technology in various fields.
Mapping the Magnetic Anisotropy at the Atomic Scale in Dysprosium Single‐Molecule Magnets
Authors: Klahn Emil A. , Gao Chen , Gillon Beatrice , Gukasov Arsen , Fabrèges Xavier , Piltz Ross O. , Jiang Shang‐Da , Overgaard Jacob 
Published: October 2018

AbstractInvited for the cover of this issue is the group of Shang‐Da Jiang at Peking University and Jacob Overgaard at Aarhus University. Read the full text of the article at 10.1002/chem.201803300.
Synthesis and Characterization of the First Tin Fluoride Borate Sn3[B3O7]F with Second Harmonic Generation Response
Authors: Schönegger Sandra , Jantz Stephan G. , Saxer Andreas , Bayarjargal Lkhamsuren , Winkler Björn , Pielnhofer Florian , Höppe Henning A. , Huppertz Hubert 
Published: October 2018

AbstractInvited for the cover of this issue is work resulting from an international research cooperation of the Huppertz and Höppe groups (University of Innsbruck, Austria and University of Augsburg, Germany) with Lkhamsuren Bayarjargal associated to the Winkler Group (University of Frankfurt, Germany), Florian Pielnhofer (University of Regensburg, Germany), and Andreas Saxer (University of Innsbruck, Austria). The image depicts synthesis and crystal structure of the first hydrothermally synthesized tin fluoride borate Sn3[B3O7]F. Read the full text of the article at 10.1002/chem.201803478.
Chemoimmunotherapy with inotuzumab ozogamicin combined with mini‐hyper‐CVD, with or without blinatumomab, is highly effective in patients with Philadelphia chromosome–negative acute lymphoblastic leukemia in first salvage
Authors: Jabbour Elias , Sasaki Koji , Ravandi Farhad , Huang Xuelin , Short Nicholas J. , Khouri Maria , Kebriaei Partow , Burger Jan , Khoury Joseph , Jorgensen Jeffrey , Jain Nitin , Konopleva Marina , Garcia‐Manero Guillermo , Kadia Tapan , Cortes Jorge , Jacob Jovitta , Montalbano Kathryn , Garris Rebecca , O’Brien Susan , Kantarjian Hagop M. 
Published: October 2018

BackgroundThe outcomes of patients with relapsed or refractory (R‐R) acute lymphoblastic leukemia (ALL) are poor. Inotuzumab ozogamicin and blinatumomab have single‐agent activity in R‐R ALL. Their addition to low‐intensity chemotherapy may further improve the outcomes of patients with ALL in their first relapse.MethodsThe chemotherapy was lower in intensity than conventional hyperfractionated cyclophosphamide, vincristine, adriamycin, and dexamethasone and was called mini‐hyperfractionated cyclophosphamide, vincristine, and dexamethasone (or mini‐HCVD). Inotuzumab was given on day 3 of each of the first 4 cycles at 1.8 to 1.3 mg/m2 for cycle 1, and this was followed by 1.3 to 1.0 mg/m2 for subsequent cycles. From patient 39 onward, the inotuzumab dose was reduced and fractionated into weekly doses (0.6 and 0.3 mg/m2 during cycle 1 and 0.3 and 0.3 mg/m2 during subsequent cycles), and blinatumomab was administered for up to 4 cycles after inotuzumab therapy.ResultsForty‐eight patients with Philadelphia chromosome–negative ALL with a median age of 39 years were treated during their first relapse. Overall, 44 patients (92%) responded, with 35 of them (73%) achieving a complete response. The overall minimal residual disease negativity rate among the responders was 93%. Twenty‐four patients (50%) underwent allogeneic stem cell transplantation (ASCT). Veno‐occlusive disease of any grade occurred in 5 patients (10%). With a median follow‐up of 31 months, the median progression‐free survival (PFS) and the median overall survival (OS) were 11 and 25 months, respectively. The 2‐year PFS and OS rates were 42% and 54%, respectively. Of the 24 patients (50%) who underwent ASCT, 14 patients were alive at the last follow‐up (13 [54%] in remission). Of the remaining 20 responding patients who did not undergo subsequent ASCT, 6 (30%) remained in remission at the last follow‐up. According to propensity score matching, the combination of mini‐HCVD and inotuzumab with or without blinatumomab conferred better outcomes than intensive salvage chemotherapy or inotuzumab alone.ConclusionsThe combination of inotuzumab and low‐intensity mini‐HCVD chemotherapy with or without blinatumomab shows encouraging results in patients with ALL in first salvage.
Color Engineering of Silicon Nitride Surfaces to Characterize the Polydopamine Refractive Index
Authors: Vega Milena , Martín del Valle Eva M. , Pérez Maximiliano , Pecharromán Carlos , Marcelo Gema 
Published: October 2018

AbstractA simple methodology to generate polydopamine (PDA) surfaces featured with color due to thin‐film interference phenomena is presented. It is based on depositing ultra‐thin films of polydopamine on a Si/Si3N4 wafer that exhibits an interferential reflectance maximum right at the visible/UV boundary (∼400 nm). Therefore, a small deposit of PDA modifies the optical path, in such manner that the wavelength of the maximum of reflectance red shifts. Because the human eye is very sensitive to any change of the light spectral distribution at the visible region, very small film thickness changes (∼30 nm) are enough to notably modify the perceived color. Consequently, a controlled deposit of PDA, tune the color along the whole visible spectrum. Additionally, good quality of PDA deposits allowed us to determine the refractive index of polydopamine by ellipsometry spectroscopy. This data can be crucial in confocal skin microscopic techniques, presently used in diagnosis of skin tumors.
Acceleration of 3D DOSY NMR by Spatial Encoding of the Chemical Shift
Authors: Jacquemmoz Corentin , Dumez Jean‐Nicolas 
Published: October 2018

AbstractDiffusion‐ordered NMR spectroscopy (DOSY) is a powerful method for the analysis of solution mixtures. With 3D DOSY, the 2D NMR spectra of a mixture's components can be separated according to the translational diffusion coefficient of each component. The acquisition of 3D DOSY data is, however, very time‐consuming because of the need to consecutively acquire scans for both the diffusion and the indirect spectral dimensions. We show that spatial encoding of the indirect spectral dimension, of the kind used in ultrafast 2D NMR, can accelerate 3D DOSY experiments by an order of magnitude or more. This is illustrated with homonuclear single‐quantum (COSY) and double‐quantum (DQS) correlation spectra. Implementations with concatenated and incorporated (iDOSY) diffusion blocks are compared and in both cases, 2D spectra are separated with less than 6 min of experiment time.
Spectroscopic Characterization of the Product Ions Formed by Electron Ionization of Adamantane
Authors: Bouwman Jordy , Horst Stefan , Oomens Jos 
Published: October 2018

AbstractA structural characterization of the products formed in the dissociative electron ionization of adamantane (C10H16) is presented. Molecular structures of product ions are suggested based on multiple‐photon dissociation spectroscopy using the Free Electron Laser for Infrared eXperiments (FELIX) in combination with quantum‐chemical calculations. Product ions are individually isolated in an ion trap tandem mass spectrometer and their action IR spectra are recorded. Atomic hydrogen loss from adamantane yields the 1‐adamantyl isomer. The IR spectrum of the C8H11+ product ion is best reproduced by computed spectra of 2‐ and 4‐protonated meta‐xylene and ortho‐ and para‐protonated ethylbenzenes. The spectrum of the product ion at m/z 93 suggests that it is composed of a mixture of ortho‐protonated toluene, para‐protonated toluene and 1,2‐dihydrotropylium, while the spectrum of the m/z 79 ion is consistent with the benzenium ion. This study thus suggests that adamantane is efficiently converted into aromatic species and astrophysical implications for the interstellar medium are highlighted.
A Highly Reversible and Low‐Cost Sulfur‐Graphite Dual‐Ion Battery
Authors: Shuai Yi , He Xuan , Zhang Zeping , Chen Kanghua , Lou Jin , Wang Yu , Li Na 
Published: October 2018

The development of energy storage systems (ESSs) has received increasing attention due to the environmental degradation and fossil fuel shortage. In this study, a highly reversible sulfur‐graphite dual‐ion battery is developed, in which sulfurized polyacrylonitrile (S@PAN) is used as the anodic material. Compared with a graphite (372 mAh g−1) or aluminum (structural instability) anode in a dual‐ion battery, this anodic material exhibits an excellent structural stability and a high specific capacity during lithiation or delithiation. Statistically, a considerable specific capacity of 750 mAh g−1 when calculated based on the weight of S@PAN over a voltage plateau of ≈2 V with only a 7% capacity loss is achieved after 50 cycles at 100 mA g−1 and shows an attractive rate performance at different current densities. This sulfur‐graphite dual‐ion battery is considered to become a promising ESS candidate.
Variable hillslope‐channel coupling and channel characteristics of forested mountain streams in glaciated landscapes
Authors: Hassan Marwan A. , Bird Stephen , Reid David , Ferrer‐Boix Carles , Hogan Dan , Brardinoni Francesco , Chartrand Shawn 
Published: October 2018

AbstractChannel morphology of forested, mountain streams in glaciated landscapes is regulated by a complex suite of processes, and remains difficult to predict. Here, we analyze models of channel geometry against a comprehensive field dataset collected in two previously glaciated basins in Haida Gwaii, B.C., to explore the influence of variable hillslope–channel coupling imposed by the glacial legacy on channel form. Our objective is to better understand the relation between hillslope–channel coupling and stream character within glaciated basins. We find that the glacial legacy on landscape structure is characterized by relatively large spatial variation in hillslope–channel coupling. Spatial differences in coupling influence the frequency and magnitude of coarse sediment and woody material delivery to the channel network. Analyses using a model for channel gradient and multiple models for width and depth show that hillslope–channel coupling and high wood loading induce deviations from standard downstream predictions for all three variables in the study basins. Examination of model residuals using Boosted Regression Trees and nine additional channel variables indicates that ~10 to ~40% of residual variance can be explained by logjam variables, ~15–40% by the degree of hillslope–channel coupling, and 10–20% by proximity to slope failures. These results indicate that channel classification systems incorporating hillslope–channel coupling, and, indirectly, the catchment glacial legacy, may present a more complete understanding of mountain channels. From these results, we propose a conceptual framework which describes the linkages between landscape history, hillslope–channel coupling, and channel form. © 2018 John Wiley & Sons, Ltd.
Wind tunnel tests of the dynamic processes that control wind erosion of a sand bed
Authors: Wang Xuesong , Zhang Chunlai , Huang Xiaoqi , Shen Yaping , Zou Xueyong , Li Jiao , Cen Songbo 
Published: October 2018

AbstractAeolian sand transport is a complicated process that is affected by many factors (e.g. wind velocity, sand particle size, surface microtopography). Under different experimental conditions, erosion processes will therefore produce different results. In this study, we conducted a series of wind tunnel experiments across a range of wind velocities capable of entraining sand particles (8.0, 10.0, 12.0, and 14.0 m s‐1) to study the dynamic changes of the shear velocity, aerodynamic roughness length, and sand transport. We found that the shear velocity and aerodynamic roughness length are not constant; rather, they change dynamically over time, and the rules that describe their changes depend on the free‐stream air velocity. For wind tunnel experiments without feeding sand into the airflow, the sand bed elevation decreases with increasing erosion time, and this change significantly affected the values of shear velocity and aerodynamic roughness length. A Gaussian distribution function described the relationships between the sand transport rate (qT) and the duration of wind erosion (T). It is therefore necessary for modelers to consider both deflation of the bed and the time scale used when calculating sand transport or erosion rates. © 2018 John Wiley & Sons, Ltd.
Estimating returns to fertilizer adoption with unobserved heterogeneity: Evidence from Ethiopia
Authors: Wossen Tesfamicheal , Gatiso Tsegaye T. , Kassie Menale 
Published: October 2018

AbstractThis paper examines the relationship between chemical fertilizer adoption and agricultural productivity in Ethiopia. Our results suggest that average returns to fertilizer adoption are high. Further, we find substantial heterogeneity across farm households in returns to fertilizer adoption, with comparative advantage playing a significant role in the adoption decision of farmers. While the adoption decision of farmers was largely rational, fertilizer use across plots was sub‐optimal. The results of this paper underscore the importance of improving farmers awareness about proper use of fertilizer through site‐specific extension services for improving agricultural productivity.
Depression and excess mortality in the elderly living in low‐ and middle‐income countries: Systematic review and meta‐analysis
Authors: Brandão Diego José , Fontenelle Leonardo Ferreira , da Silva Simone Almeida , Menezes Paulo Rossi , Pastor‐Valero Maria 
Published: October 2018

ObjectiveTo investigate the association between depression and mortality in the elderly living in low‐ and middle‐income countries.MethodsA systematic review and meta‐analysis was performed. We searched in five electronic databases for observational studies investigating the association between mortality and depression. Two reviewers worked independently to select articles, extract data, and assess study quality.ResultsA total of 10 studies including 13 828 participants (2402 depressed and 11 426 nondepressed) from six countries (Brazil, four articles; China, two articles; Botswana, India, South Africa, and South Korea, one article) were included. The overall unadjusted relative risk (RR) of mortality in depressed relative to nondepressed participants was 1.62 (95% CI, 1.39‐1.88; P < 0.001), with high heterogeneity (I2 = 66%; 95% CI, 33‐83; P < 0.005). After adjustment for publication bias, the overall RR decreased to 1.60 (95% CI, 1.37‐1.86; P < 0.001). No significant differences were observed between subgroups except those defined by study quality. The high‐quality studies had a pooled RR of 1.48 (95% CI, 1.32‐1.67; P < 0.001), while the low‐quality studies resulted had a pooled RR of 1.82 (95% CI, 1.25‐2.65; P < 0.005).ConclusionsDepression is associated with excess mortality in the elderly living in low‐ and middle‐income countries. In addition, this excess mortality does not differ substantially from that found in high‐income countries. This suggests environmental factors occurring in low‐ and middle‐income countries might not have a direct association with the excess mortality in the depressed elderly.