bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting microRNA‐disease association based on microRNA structural and functional similarity network
Authors: Ding Tao , Gao Jie , Zhu Shanshan , Xu Junhua , Wu Min 
Published: May 2019

BackgroundIncreasing evidences indicate that microRNAs (miRNAs) are functionally related to the development and progression of various human diseases. Inferring disease‐related miRNAs can be helpful in promoting disease biomarker detection for the treatment, diagnosis, and prevention of complex diseases.MethodsTo improve the prediction accuracy of miRNA‐disease association and capture more potential disease‐related miRNAs, we constructed a precise miRNA global similarity network (MSFSN) via calculating the miRNA similarity based on secondary structures, families, and functions.ResultsWe tested the network on the classical algorithms: WBSMDA and RWRMDA through the method of leave‐one‐out cross‐validation. Eventually, AUCs of 0.8212 and 0.9657 are obtained, respectively. Also, the proposed MSFSN is applied to three cancers for breast neoplasms, hepatocellular carcinoma, and prostate neoplasms. Consequently, 82%, 76%, and 82% of the top 50 potential miRNAs for these diseases are respectively validated by the miRNA‐disease associations database miR2Disease and oncomiRDB.ConclusionTherefore, MSFSN provides a novel miRNA similarity network combining precise function network with global structure network of miRNAs to predict the associations between miRNAs and diseases in various models.
State Ownership and “State-Sharing”: The Role of Collective Identities and the Sociopolitical Cleavage between Ethnic Macedonians and Ethnic Albanians in the Republic of North Macedonia
Authors: Piacentini Arianna Maria 
Published: May 2019

AbstractThe article analyzes, from a historical and institutional perspective, the sociopolitical cleavages existing between ethnic Macedonians and ethnic Albanians in the Republic of North Macedonia. Although primarily ethnic, the division between the two groups is deeply connected to state ownership and the official status each group occupies and wishes to occupy in it. By scrutinizing both groups’ claims, standpoints, and dissatisfactions, the article asserts that the implementation of consociationalism in 2001, through the de facto institutionalization of ethnicity, has partly soothed both groups’ frustrations, using the pragmatic exploitation of the existing ethnic divide as a proxy for “state sharing” in addition to power sharing.
The Carboneras Fault Zone (southeastern Spain) revisited with Ground Penetrating Radar – Quaternary structural styles from high-resolution images
Authors: Reicherter K.R. , Reiss S. 
Published: May 2019

AbstractThe Carboneras Fault Zone (CFZ) represents an active set of sinistral strike-slip faults in the Betic Cordilleras of southeastern Spain. It constitutes a major segment of the ‘Trans-Alboran shear zone’ during the Cenozoic, striking NE-SW. The CFZ separates the Cabo de Gata Block (Neogene volcanics) against Neogene basinal sediments and the metamorphic basement of the Alpujarride Complex.Three sites along the CFZ were examined with Ground Penetrating Radar techniques. Radar surveying was complemented by structural studies. Shallow-depth high-resolution imaging of Tyrrhenian beach terraces exhibited both vertical and minor horizontal offsets in the Rambla Morales site in the south. A sinistral strike-slip fault associated with minor thrust faults in a positive flower structure was detected in the middle segment along the La Serrata ridge, sealed by a caliche of late Pleistocene age (> 10 ka). The Playa de Bolmayor section yielded sub-surface evidence for several faults probably related to recent activity of individual fault strands. Our results suggest a distributed tectonic activity of the CFZ during the Late Quaternary.
Seismogenic faulting in an area of low seismic activity: Paleoseismicity of the El Camp fault (Northeast Spain)
Authors: Masana E. , Villamarín J.A. , Cabañero J. Sánchez , Plaza J. , Santanach P. 
Published: May 2019

AbstractGiven that earthquakes do not occur only along high slip-rate faults, slow moving seismogenic faults should be characterized in order to minimize seismic hazard uncertainties. Although no historical earthquakes related to the El Camp fault have been documented, earlier regional geological analysis and the presence of a fault scarp provide evidence of its activity. A paleoseismological study on the southern part of the fault was performed in accordance with the following steps: 1) geological and géomorphologie analysis focussing on the detection of evidence for the seismogenic behavior of the fault, 2) near fault analysis to select the best trenching sites, and 3) trenching to establish and characterize the paleoseismic events. Different dating procedures were used in regional and trenching analyses (Thermoluminiscence, U/Th, Radiocarbon, Pollen analysis). The seismogenic nature of the fault was established by the presence of liquefaction features related to the fault, and by the presence of colluvial wedges composed of large angular blocks. We identified a segment boundary to the north of the Porquerola creek and we focussed our attention on the southern segment, which was active after 125000 yr. The slip rate in this southern segment is 0.02 mm/yr. A minimum of three seismic events were detected, from young to old: the last event Z took place some time prior to 1195 yr AD, the penultimate event Y between event X and the Holocene, and, finally, event X occurred after 125000 yr and prior to 60000 yr. The recurrence period is between 25000 and 35000 yr, the elapsed time is estimated to be no longer than 3000 yr; and the maximum estimated earthquake considering both the onshore and the offshore part of the fault is Mw 6.7 +/-0,5.
Major active faults in Italy: available surficial data
Authors: Galadini Fabrizio , Meletti Carlo , Vittori Eutizio 
Published: May 2019

AbstractAn inventory of the available surficial data on active faults in Italy has been compiled by gathering all the available information on peninsular Italy (project by CNR, National Group for the Defense against Earthquakes), the central-eastern Alps and the Po Plain (EC ‘PALEOSIS’ project). Such information has been summarised in maps (reporting surficial expressions of faults with length L≥11 km) and in a table where fault parameters relevant for seismic hazard assessment (e.g. slip rates, recurrence intervals for surface faulting events, etc..) have been reported. Based on the geological characteristics of the Italian territory, a fault has been considered as active if it shows evidence of Late Pleistocene-Holocene displacements. Active faults in Italy are distributed throughout the entire Apennine chain, in the Sicilian and Calabrian regions and in some Alpine sectors, but knowledge is not homogeneously distributed through the territory. The largest amount of data is related to the central Apennines. In contrast, fault geometries and parameters are less well defined in the southern Apennines, Sicily and Calabria, where investigations have started more recently. Knowledge is sparse in the northern Apeninnes, where data necessary to define fault parameters are lacking and also the chronology of the activity has to be considered cautiously. Abundant blind faulting in the Po Plain hinders the detection of active faults by means of the classical surficial investigations and therefore the present knowledge is limited to the Mantova fault. Blind faults and the peculiar recent geological history of the Alpine areas, which is strongly conditioned by the erosional and depositional activity during and after the last glacial maximum, also hinder the identification of active faults in the central-eastern Alps. Some faults in this Alpine sector are believed to be active, but data on their segmentation are still missing. Available information indicates that Italian active faults are usually characterised by slip rates lower than 1 mm/yr. Recurrence intervals for surface faulting events are longer than 1,000 years in the central and southern Apennines. This review on the Italian active faults represents the first step to produce a map of the major seismic sources in Italy, which in turn will result from the merge of surficial data with seismological and geological subsurficial data. The available knowledge gathered in this paper indicates those areas where data are presently sparse. It should be, therefore, possible to better plan future geomorphological and paleoseismological investigations.
FLAT RING EPIMORPHISMS OF COUNTABLE TYPE
Authors: POSITSELSKI LEONID 
Published: May 2019

AbstractLet R→U be an associative ring epimorphism such that U is a flat left R-module. Assume that the related Gabriel topology $\mathbb{G}$ of right ideals in R has a countable base. Then we show that the left R-module U has projective dimension at most 1. Furthermore, the abelian category of left contramodules over the completion of R at $\mathbb{G}$ fully faithfully embeds into the Geigle–Lenzing right perpendicular subcategory to U in the category of left R-modules, and every object of the latter abelian category is an extension of two objects of the former one. We discuss conditions under which the two abelian categories are equivalent. Given a right linear topology on an associative ring R, we consider the induced topology on every left R-module and, for a perfect Gabriel topology $\mathbb{G}$, compare the completion of a module with an appropriate Ext module. Finally, we characterize the U-strongly flat left R-modules by the two conditions of left positive-degree Ext-orthogonality to all left U-modules and all $\mathbb{G}$-separated $\mathbb{G}$-complete left R-modules.
The Buddhist salvation of Ajātaśatru and the Jaina non-salvation of Kūṇika
Authors: Wu Juan 
Published: May 2019

AbstractThis article examines Buddhist and Jaina attitudes towards the salvation of the Magadhan king Ajātaśatru (alias Kūṇika), a narrative character found in both Buddhist and Jaina traditions. A number of Buddhist texts prophesy that Ajātaśatru, despite his next birth in hell, will attain liberation in his final birth. Jaina sources also speak of Kūṇika's descent into hell, but give no prophecy of his ultimate liberation. While the Buddhists offered various solutions to Ajātaśatru's sinful condition, the Jainas proposed no remedy to mitigate the consequences of Kūṇika's sins. The Buddhist prophecies of Ajātaśatru's eventual liberation indicate that some Buddhists in ancient India were particularly concerned with the salvation of an archetypal villain such as Ajātaśatru. The Jaina silence on Kūṇika's destiny suggests that the Jainas in general had little interest in bringing this violent figure to liberation, and deemed him incapable of overcoming his “false view of reality” (mithyātva) due to his strong passions.
Presence of PolyclonalPseudomonas aeruginosain an Intensive Care Unit A 27-Month Prospective Study on Molecular Epidemiology
Authors: Cortés Pilar , Mariscal Dolors , Vallés Jordi , Rello Jordi , Coll Pere 
Published: May 2019

AbstractPseudomonas aeruginosawas isolated in 22.2% of 305 intensive care unit environmental cultures. A high genetic heterogeneity (18 pulsotypes) was evident. Taps and related surfaces were a stable reservoir for certain pulsotypes. The 15.4% of theP aerugi-Mosa-positive cultures were polyclonal. Different colony morpho-types should be assayed in surveillance studies.
Effect of plasma urea concentration at the time of insemination or embryo transfer on pregnancy rate in cattle
Authors: Gath V.P. , Fahey J. , Snijders S.E.M. , O'Callaghan D. 
Published: May 2019

AbstractPlasma urea concentrations have been used as a diagnostic tool in the investigation of reproductive performance in cattle. Data were compiled from three recent studies on bovine fertility and a retrospective comparison of plasma urea concentrations was made between those animals that conceived to an insemination or embryo transfer. In studies I and 2 plasma urea concentrations around the time of insemination were determined. Pregnancies were diagnosed using ultrasonography 35 days later. There was no significant difference between the mean plasma urea concentrations around the time of insemination in the cattle subsequently diagnosed pregnant or not pregnant. In study 3, in vitro produced good quality embryos were transferred into three groups of beef heifers. The three groups were allocated to diets of high energy / high urea, high energy / no urea and low energy / high urea. The plasma urea concentrations at the time of embryo transfer were different between the three groups. However, the pregnancy rates 28 days post transfer, were not significantly different between the three groups. This suggests that the previously reported effects of high protein diets on fertility are not solely due to disruptive effects on the uterine environment. The main effect of urea on fertility may be on oocyte development within the follicle. Overall, these results indicate that measurement of plasma urea concentrations in individual animals around the time of insemination or embryo transfer is not a useful predictor of subsequent pregnancy rate.
Relationships between body condition score (BCS), biochemical blood parameters and pregnancy rates in Prim'Holstein cows under subtropical conditions
Authors: Tillard E. , Nabeneza S. , Faye B. , Humblot P. 
Published: May 2019

AbstractThe relationships between body condition score (BCS), metabolic measurements and pregnancy rates were studied from 214 cows belonging to 6 herds located in Reunion Island between January and December 1998. BCS (0 to 5 scale) and biochemical blood parameters were measured before calving, 0-30, 60-90 and 120-150 days post-partum. Pregnancy status was also checked precisely after 171 AI's (n=104 cows) by EIA progesterone determination in milk 23 to 24 days after AI and pregnancy specific protein B (PSPB) measurements 30 to 45 days after AI and was further confirmed by rectal palpation by 60 days post AI. A preliminary analysis led to determine 3 groups of herds according to their pregnancy rates (40%, 26% and 14.5% respectively for group 1, 2 and 3 cows). Significant differences between the 3 groups were found for BCS, glucose and urea (p < 0.0001) and a significant main effect of the post-partum stage was observed as well (p < 0.0001). Mean BCS were not different in the 3 groups before calving but were higher in group 1 cows than in group 2 and 3 cows at all other stages studied. A similar trend was found for urea. Glucose concentrations were severely depressed in group 3 cows when compared to group 1 and 2 cows whatever the stage studied. These results sugggest that variables illustrating negative energy balance (BCS decrease and low glucose concentrations) or deficit in nitrogen supply (urea concentrations) on a herd basis are related to poor pregnancy rates.
Adverse childhood experiences predict autonomic indices of emotion dysregulation and negative emotional cue-elicited craving among female opioid-treated chronic pain patients
Authors: Garland Eric L. , Reese Sarah E. , Bedford Carter E. , Baker Anne K. 
Published: May 2019

AbstractThrough autonomic and affective mechanisms, adverse childhood experiences (ACEs) may disrupt the capacity to regulate negative emotions, increasing craving and exacerbating risk for opioid use disorder (OUD) among individuals with chronic pain who are receiving long-term opioid analgesic pharmacotherapy. This study examined associations between ACEs, heart rate variability (HRV) during emotion regulation, and negative emotional cue-elicited craving among a sample of female opioid-treated chronic pain patients at risk for OUD. A sample of women (N= 36, mean age = 51.2 ± 9.5) with chronic pain receiving long-term opioid analgesic pharmacotherapy (mean morphine equivalent daily dose = 87.1 ± 106.9 mg) were recruited from primary care and pain clinics to complete a randomized task in which they viewed and reappraised negative affective stimuli while HRV and craving were assessed. Both ACEs and duration of opioid use significantly predicted blunted HRV during negative emotion regulation and increased negative emotional cue-elicited craving. Analysis of study findings from a multiple-levels-of-analysis approach suggest that exposure to childhood abuse occasions later emotion dysregulation and appetitive responding toward opioids in negative affective contexts among adult women with chronic pain, and thus this vulnerable clinical population should be assessed for OUD risk when initiating a course of extended, high-dose opioids for pain management.
Spindle and chromosome configuration analysis of human biopsied versus non-biopsied embryos by confocal laser scanning microscopy following vitrification
Authors: Chatzimeletiou Katerina , Vanderzwalmen Pierre , Panagiotidis Yannis , Papatheodorou Achilleas , Karagiannidis Alexandros , Kolibianakis Efstratios , Grimbizis Grigoris , Prapas Nikos , Prapas Yannis , Tarlatzis Basil C. 
Published: May 2019

SummaryThe aim of this study was to investigate the effects of zona drilling and biopsy on day 3 followed by vitrification on day 5 on the cytoskeleton and development of human embryos, by analysing survival rates and spindle and chromosome configurations by fluorescence and confocal laser scanning microscopy in human biopsied and non-biopsied embryos. In total, 98 human blastocysts (50 non-biopsied and 48 following biopsy on day 3) were vitrified on day 5 using either a commercial dimethyl sulphoxide (DMSO)-free vitrification kit or increasing concentrations of DMSO/EG (5%/5–10%/10–20%/20%). Following warming, the blastocysts were allowed to recover in culture for 24 h and were immunostained with α-tubulin, acetylated tubulin, and/or γ-tubulin antibodies in combination with 4′,6-diamidino-2-phenylindole (DAPI). Labelled embryos were examined by both fluorescence and confocal laser scanning microscopy. The survival rates following warming (92% non-biopsied vs 83.3% biopsied) and the incidence of normal spindle chromosome configurations was not statistically different between the two groups (65.2% non-biopsied vs 59.2% biopsied,P>0.05). The incidence of spindle abnormalities including multipolarity, chromosome lagging, congression failure and chromosome bridging were also similar between the two groups (P>0.05). This study is the first to compare the incidence of cytoskeletal abnormalities in biopsied and non-biopsied human embryos following vitrification. We conclude that there was no significant difference in the survival rates and the incidence of spindle abnormalities between the two groups.
An Ex Ante Assessment of Investments in Texas Grapefruit under Uncertainty
Authors: Elmer Nicole A. , Thurow Amy P. , Johnson Jason L. , Rosson C. Parr 
Published: May 2019

AbstractThe Dixit-Pindyck model was applied to examine the hypothesis that uncertainty associated with grapefruit production costs and returns is an important determinant of Texas grapefruit growers' investment behavior. Freezes, price variability, and the effects of expanded trade were analyzed as risk factors. An investment decision rule based on a net-present value calculation would approve a 25-year commitment to a 20-acre grapefruit grove, given a 6-percent discount rate. The modified hurdle rate, calculated using an ex ante version of the Dixit-Pindyck model, is 24 percent. The major source of the risk borne by Texas grapefruit investors is from freezes, rather than from expanded trade.
Assessing Spatial Break-even Variability in Fields with Two or More Management Zones
Authors: English Burton C. , Mahajanashetti S.B. , Roberts Roland K. 
Published: May 2019

AbstractFarmers are interested in knowing whether applying inputs at variable rates across a field is economically viable. The answer depends on the crop, the input, their prices, the cost of variable rate technology (VRT) versus uniform rate technology (URT), and the spatial and yield response variability within each field. Methods were investigated for determining the range of spatial variability over which the return to VRT covers its additional cost compared with URT in fields with multiple management zones. Models developed in this article, or variants thereof, could be used to help farmers make the VRT adoption decision.
Independent effects of dietary linoleic and linolenic fatty acids on the conjugated linoleic acid content of cows’ milk
Authors: Lock A.L. , Garnsworthy P.C. 
Published: May 2019

AbstractIt may be desirable to increase the level of conjugated linoleic acid (CLA) in milk as a health benefit in human nutrition. The purpose of this work was to separate the effects of linoleic and linolenic acids on CLA production in dairy cows and to determine to what extent endogenous synthesis contributes to cis-9, trans-11 CLA concentration in milk fat. Eight lactating cows and four non-lactating duodenal fistulated cows were used in a 4 ✕ 4 Latin-square design. All cows received a basal diet of grass silage that was supplemented with one of four concentrates, which were designed to differ in their linoleic and linolenic acid contents. The oil components of the concentrates were produced from mixtures of olive, linseed, rape, soya and sunflower oils to produce the four treatments: low linoleic/ low linolenic acid (LL), low linoleic/high linolenic acid (LH), high linoleic/low linolenic acid (HL) and high linoleic/ high linolenic acid (HH). Milk cis-9, trans-11 CLA contents were 0·8, 0·9, 0·9 and 1·1 g/100 g fatty acid methyl esters (P < 0·05) and yields were 5, 7, 7 and 8 g/day (P < 0·05) for the LL, LH, HL and HH treatments, respectively. The yields of trans-C18:1fatty acids in milk were 19, 22, 21 and 23 g/day (P < 0·05), respectively. Taking the data for the cis-9, trans-11 CLA content and flow of duodenal fluid from the fistulated cows and representing this in terms of dietary intake by the lactating animals, the amounts of cis-9, trans-11 CLA produced in the rumen were calculated to be 0·8, 0·9, 1·2 and 1·1 g/day (P < 0·05) and for trans-C18:1fatty acids 58, 58, 66 and 69 g/day (P < 0·05). Increasing linoleic and/or linolenic acids in the diet can increase the cis-9, trans-11 CLA content of cows’ milk. Only diets high in linoleic acid increased cis-9, trans-11 CLA production in the rumen. On all four diets, more than 80% of cis-9, trans-11 CLA in milk was produced endogenously by Δ9-desaturase from trans-11 C18:1in the mammary gland. Cows on the same diet have different milk fat cis-9, trans-11 CLA concentrations that may be partially explained by differences in Δ9-desaturase activity between cows. Increasing the activity of Δ9-desaturase in the mammary gland may offer greater potential for enhancing the cis-9, trans-11 CLA content of milk fat than increasing cis-9, trans-11 CLA production in the rumen.