bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phthalocyanine-based solid-state electrolyte for high-capacity and long-life lithium-ion batteries
Authors: Lucente Leah , Lawson Jacob , Feld William , Firsich David , Kichambare Padmakar , Jenkins Thomas , Rodrigues Stanley , Scanlon Lawrence 
Published: October 2024

A new solid-state electrolyte (SSE) with low energy activation for lithium-ion conduction was designed and tested in an all-solid-state battery configuration with a lithium metal anode and a lithium iron phosphate (LiFePO[Formula: see text] cathode. The aromatic character of the phthalocyanine-based SSE facilitates cell stabilization against lithium metal dendrites, and the low energy of activation enables battery cycling at -20 °C. The use of the phthalocyanine-based SSE necessitated the development of an in-situ process for the formation of an effective solid electrolyte interphase (SEI) layer between the anode and the SSE. Such a procedure enabled battery cycling over a 12-to-16-month time frame. The cells delivered high discharge capacities of up to 291.3 mAh/g at 23 °C and 194.5 mAh/g at -20 °C. All cells were fabricated in a dry room via simple solution casting of the soluble SSE onto either an aerosol-jet-deposited or tape-cast LiFePO4 cathode.
Qualitatively Analyzing Optimization Objectives in the Design of HPC Resource Manager
Authors: Boëzennec Robin , Dufossé Fanny , Pallez Guillaume 
Published: October 2024

A correct evaluation of scheduling algorithms and a good understanding of their optimization criteria are key components of resource management in HPC. In this work, we discuss bias and limitations of the most frequent optimization metrics from the literature. We provide elements on how to evaluate performance when studying HPC batch scheduling.
We experimentally demonstrate these limitations by focusing on two use-cases: a study on the impact of runtime estimates on scheduling performance, and the reproduction of a recent high-impact work that designed an HPC batch scheduler based on a network trained with reinforcement learning. We demonstrate that focusing on quantitative optimization criterion (“our work improves the literature by X%”) may hide extremely important caveat, to the point that the results obtained are opposed to the actual goals of the authors.
Key findings show that mean bounded slowdown and mean response time are hazardous for a purely quantitative analysis in the context of HPC. Despite some limitations, utilization appears to be a good objective. We propose to complement it with the standard deviation of the throughput in some pathological cases. Finally, we argue for a larger use of area-weighted response time, that we find to be a very relevant objective.
Novel Ball-Type Phthalocyanines with Eight Benzotriazole Groups: Synthesis, Computational DFT Studies, and Supercapacitor Properties
Authors: Koçyiğit Nilüfer , Ramzy Ahmed Taalat Anwar , Yazar Sibel , Arvas Melih Beşir , Acar-Selçuki Nursel , Özer Metin , Bekaroğlu Özer 
Published: October 2024

Novel four MBTOB-bridged ball-type metallophthalocyanines were obtained from 4,4′-((methylenebis(6-(2H-benzo[d][1, 2, 3]triazol-2-yl)−4-(2,4,4-trimethylpentan-2-yl)−2, 1-phenylene))bis(oxy))diphthalonitrile by means of transition metal (II) acetate salts in 2-dimethylaminoethanol. The new starting bisphthalonitrile compound was accomplished from 2,2′-methylenebis[6-(benzotriazol-2-yl)−4-tert-octylphenol] and 4-nitrophthalonitrile in dimethylformamide under the catalysis of potassium carbonate at 50 °C. The structural characterization of the compounds was accomplished by infrared, proton-nuclear magnetic resonance, matrix-assisted laser desorption/ionisation time-of-flight mass, and ultraviolet–visible spectroscopic methods. The supercapacitor performances of the electrodes were examined by cyclic voltammetry, galvanostatic charge discharge, and electrochemical impedance spectroscopy analyses. The specific capacitances obtained from the GCD measurements were calculated as 320.4 ± 15.1 F g−1 for ball-type zinc (II) phthalocyanine in three electrode systems. The highest specific capacitance value was found in the electrode containing ball-type nickel (II) phthalocyanine as 929.8 ± 32.8 F g−1 at a scan rate of 100 mV s−1. In symmetric supercapacitor measurements, the capacitance retention value was 100.7% after 5000 cycles.
Integrating Molecular Imaging and Transcriptomic Profiling in Advanced HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine: An Analysis of the ZEPHIR Clinical Trial
Authors: Rediti Mattia , Fimereli Danai , Mileva Magdalena , Wimana Zéna , Venet David , Flamen Patrick , Guiot Thomas , de Vries Elisabeth G.E. , Schröder Carolien P. , Menke-van der Houven van Oordt Catharina Willemien , Maetens Marion , Majjaj Samira , Larsimont Denis , Rothé Françoise , Sotiriou Christos , Gebhart Géraldine 
Published: October 2024

Abstract

Purpose:
The ZEPHIR clinical trial evaluated the role of [89Zr]trastuzumab-PET/CT (HER2-PET/CT) and 2-[18F]fluoro-2-deoxy-D-glucose PET/CT ([18F]FDG-PET/CT) in predicting outcomes in patients with advanced HER2-positive breast cancer treated with trastuzumab emtansine (T-DM1). In this study, we combined molecular/metabolic imaging and transcriptomic data to investigate the biological processes associated with [89Zr]trastuzumab and [18F]FDG uptake and to dissect the mechanisms involved in T-DM1 resistance.

Experimental Design:
RNA was extracted from metastasis biopsies obtained in the ZEPHIR trial. HER2-PET/CT and [18F]FDG-PET/CT imaging data of biopsied lesions were integrated with transcriptomic data. Lesions were compared based on the level of [89Zr]trastuzumab uptake as well as on the presence/absence of metabolic response, defined comparing baseline and on-treatment [18F]FDG-PET/CT.

Results:
We analyzed matched transcriptomic and molecular/metabolic imaging data for 24 metastases. Genes and pathways involved in extracellular matrix (ECM) organization and glycosylphosphatidylinositol synthesis were enriched in lesions presenting low [89Zr]trastuzumab uptake. [18F]FDG uptake at baseline correlated with proliferation and immune-related processes. Hypoxia and ECM-related processes were enriched in lesions showing no metabolic response to T-DM1, whereas immune-related processes were associated with high [89Zr]trastuzumab uptake and metabolic response. Gene signatures including differentially expressed genes according to [89Zr]trastuzumab uptake and metabolic response showed predictive value in an external cohort.

Conclusions:
To the best of our knowledge, this study represents the first correlative analysis between [89Zr]trastuzumab tumor uptake and gene expression profiling in humans. Our findings suggest a role for ECM in impairing [89Zr]trastuzumab tumor uptake and T-DM1 metabolic response in advanced HER2-positive breast cancer, highlighting the potential of molecular imaging to depict tumor microenvironment features.
Phase I/II Investigator-Initiated Study of Olaparib and Temozolomide in SCLC: Final Analysis and CNS Outcomes
Authors: Meador Catherine B. , Digumarthy Subba R. , Yeap Beow Y. , Hung Yin P. , Mino-Kenudson Mari , Farago Anna F. , Heist Rebecca S. , Marcoux J. Paul , Rangachari Deepa , Barbie David A. , Piotrowska Zofia 
Published: October 2024

Abstract

Purpose:
Temozolomide plus PARP inhibition has shown promise in small cell lung cancer (SCLC). We previously reported outcomes from the first 50 patients (cohort 1) of a phase I/II trial of olaparib/temozolomide in recurrent SCLC. In this study, we report a final analysis of this trial, including a second cohort with an alternate dosing strategy and an exploratory analysis of central nervous system (CNS)–specific outcomes.

Patients and Methods:
This was an open-label phase I/II trial testing the combination of olaparib and temozolomide in relapsed SCLC. The primary endpoint was objective response rate (ORR). Secondary endpoints were safety, progression-free survival, and overall survival. We tested escalating doses of olaparib/temozolomide across two cohorts, both of which had temozolomide dosed on days 1 to 7 of each 21-day cycle. In previously published cohort 1, olaparib was dosed on days 1 to 7; in cohort 2, olaparib was dosed continuously.

Results:
Sixty-six patients were enrolled across the two cohorts: 50 in cohort 1 and 16 in cohort 2. The confirmed ORR of cohort 1 was 41.7% (20/48 evaluable), and the confirmed ORR of cohort 2 was 7% (1/14 evaluable; closed after dose escalation to enrollment for lack of observed efficacy). Among 15/66 patients (22.7%) with untreated brain metastases at enrollment, the best overall intracranial response was complete response in 6/15 patients, partial response in 4/15 patients, and stable disease in 3/15 patients for a CNS disease control rate of 87% (95% confidence interval, 59.5%–98.3%).

Conclusions:
Olaparib/temozolomide may be effective in relapsed SCLC, especially for patients with CNS disease. Ongoing analyses with regard to optimal dosing schedule will inform potential for future use of this combination in SCLC.
Emerging Role of the p53 Pathway in Modulating NK Cell–Mediated Immunity
Authors: Chen Yu-Chi , Bazewicz Christopher G. , Dinavahi Saketh S. , Huntington Nicholas D. , Schell Todd D. , Robertson Gavin P. 
Published: October 2024

Abstract
The p53 pathway plays an important role in role in cancer immunity. Mutation or downregulation of the proteins in the p53 pathway are prevalent in many cancers, contributing to tumor progression and immune dysregulation. Recent findings suggest that the activity of p53 within tumor cells, immune cells, and the tumor microenvironment can play an important role in modulating NK cell–mediated immunity. Consequently, efforts to restore p53 pathway activity are being actively pursued to modulate this form of immunity. This review focuses on p53 activity regulating the infiltration and activation of NK cells in the tumor immune microenvironment. Furthermore, the impact of p53 and its regulation of NK cells on immunogenic cell death within solid tumors and the abscopal effect are reviewed. Finally, future avenues for therapeutically restoring p53 activity to improve NK cell–mediated antitumor immunity and optimize the effectiveness of cancer therapies are discussed.
Gefitinib Reverses PD-L1–Mediated Immunosuppression Induced by Long-term Glutamine Blockade in Bladder Cancer
Authors: Ma Guofeng , Jia Huiqing , Li Zhiqiang , Zhang Xiangyan , Wang Liping , Zhang Zhilei , Xiao Yujing , Liang Zhijuan , Li Dan , Chen Yuanbin , Tian Xintao , Wang Yonghua , Liang Ye , Niu Haitao 
Published: October 2024

Abstract
Glutamine is a major energy source for tumor cells, and blocking glutamine metabolism is being investigated as a promising strategy for cancer therapy. However, the antitumor effect of glutamine blockade in bladder cancer remains unclear, necessitating further investigation. In this study, we demonstrated that glutamine metabolism was involved in the malignant progression of bladder cancer. Treatment with the glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON) inhibited the growth of bladder cancer cells in vitro in several ways. In addition, we observed inhibition of tumor growth in bladder cancer–bearing mice by using JHU083, a prodrug that was designed to prevent DON-induced toxicity. However, the antitumor immune effect of T cells changed from activation to inhibition as the administrated time extended. We found that both in vitro treatment with DON and in vivo prolonged administration of JHU083 led to the upregulation of PD-L1 in bladder cancer cells. Mechanistically, glutamine blockade upregulated PD-L1 expression in bladder cancer cells by accumulating reactive oxygen species, subsequently activating the EGFR/ERK/C-Jun signaling pathway. Combination treatment of JHU083 and gefitinib reversed the upregulation of PD-L1 in bladder cancer cells induced by prolonged glutamine blockade, resulting in the alleviation of T-cell immunosuppression and a significant improvement in therapeutic outcome. These preclinical findings show promise for glutamine metabolism targeting as a viable therapeutic strategy for bladder cancer, with the potential for further enhancement through combined treatment with gefitinib.
Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
Authors: Coats Josh T. , Li Shuyu , Tanaka Tomoyuki U. , Tauro Sudhir , Sutherland Calum , Saurin Adrian T. 
Published: October 2024

Abstract
Elraglusib (9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3) with preclinical studies demonstrating broad activity against many tumor types. Promising early-phase clinical trial data led to FDA orphan drug status, and a randomized phase II study in combination with cytotoxic chemotherapy in pancreatic cancer has recently completed its recruitment. Similarly, single-agent responses in adult T-cell leukemia/lymphoma and melanoma and combination treatment data in several other tumor types have been encouraging. The elraglusib mechanism of action is unknown, but it is unlikely to act through GSK3 inhibition because cytotoxicity is observed below the IC50 for GSK3, and other small molecule GSK3 inhibitors do not produce cytotoxic effects, at least in lymphoma cells. We show here that elraglusib perturbs chromosomal alignment to cause a mitotic arrest in multiple tumor lines. This arrest is caused by direct microtubule (MT) depolymerization, which prevents the attachment of kinetochores to MTs. At clinically relevant doses, these mitotically arrested cells eventually undergo mitotic slippage, leading to gross chromosome missegregation, DNA damage, and apoptosis. These effects explain the cytotoxicity of elraglusib because temporarily pausing cell-cycle progression with the CDK4/6 inhibitor palbociclib abolishes any drug-induced genotoxicity and apoptosis. In summary, elraglusib acts as a direct MT destabilizer both in vitro and across multiple cancer types, resulting in mitotic arrest, DNA damage, and apoptosis. These effects likely account for its broad pan-cancer activity, which does not rely upon GSK3 inhibition as they are not replicated by other GSK3 inhibitors.

Significance:
Elraglusib was designed as a GSK3 inhibitor and is currently in clinical trials for several cancers. We show conclusively that the target of elraglusib that leads to cytotoxicity is MTs and not GSK3. This has significant implications for ongoing clinical trials of the compound and will help in understanding off-target side effects, inform future clinical trial design, and facilitate the development of biomarkers to predict response.
Impacts of Hospital Volume and Patient-Hospital Distances on Outcomes of Older Adults Receiving Percutaneous Microaxial Ventricular Assist Devices for Cardiogenic Shock
Authors: Watanabe Atsuyuki , Miyamoto Yoshihisa , Ueyama Hiroki A. , Gotanda Hiroshi , Jentzer Jacob C. , Kapur Navin K. , Jorde Ulrich P. , Tsugawa Yusuke , Kuno Toshiki 
Published: October 2024

BACKGROUND:
Percutaneous microaxial ventricular assist devices (pVADs) have the potential to reduce mortality of patients with cardiogenic shock (CS). However, the association between the distribution of pVAD-performing centers and outcomes of CS has not been explored.

METHODS:
This observational study included Medicare fee-for-service beneficiaries aged 65 to 99 years treated with pVAD for CS from 2016 to 2020. It examined the associations between patient outcomes and 2 exposure variables: hospitals’ procedure volumes of pVAD and patient-hospital distances (in quintiles [Qn]). We developed Cox proportional hazards regression for 180-day mortality and heart failure readmission rates, and multivariable logistic regression for in-hospital outcomes, adjusting for patient demographics, comorbidities, concomitant treatments, and hospital characteristics, including CS volume, teaching status, and the ability to perform extracorporeal membrane oxygenation.

RESULTS:

A total of 6637 patients with CS underwent pVAD at 1041 hospitals, with the annualized hospital volume ranging widely from 0.3 to 55.6 cases/year. Patients treated at higher-volume centers experienced lower 180-day mortality compared with those treated at lower-volume centers (Qn1=reference; Qn2: adjusted hazard ratio [aHR], 0.88 [95% CI, 0.79–0.97]; Qn3: aHR, 0.88 [95% CI, 0.79–0.98]; Qn4: aHR, 0.88 [95% CI, 0.78–0.99]; Qn5: aHR, 0.84 [95% CI, 0.74–0.95];
P
for trend, 0.026), while we found no evidence that patient-hospital distances were associated with mortality (Qn1=reference; Qn2: aHR, 0.99 [95% CI, 0.89–1.09]; Qn3: aHR, 0.94 [95% CI, 0.85–1.04]; Qn4: aHR, 1.01 [95% CI, 0.92–1.11]; Qn5: aHR, 0.91 [95% CI, 0.82–1.01];
P
for trend, 0.160). We found no evidence that the hospital volume and patient-hospital distances were associated with in-hospital bleeding, intracranial hemorrhage, or renal replacement therapy initiation.

CONCLUSIONS:
Hospital volume was more strongly associated with mortality than patient-hospital distances, suggesting that rational distribution of pVAD-performing centers while ensuring adequate procedure volumes may optimize patient mortality.
Measuring behavioral synchronization and spatial cohesion in the activity budgets of three adult white-handed gibbon (Hylobates lar) dyads in Huai Kha Khaeng Wildlife Sanctuary, Thailand
Authors: Light Lydia E.O. , Romano Milena L. 
Published: October 2024

Abstract
Individual behavior of primates living in small groups is often seen to represent behavior of all group members due to close spatial cohesion. However, given that females expend more energy on reproduction than males (including lactation and infant carrying), females and males may exhibit different behaviors even when maintaining spatial proximity, particularly in highly seasonal or resource-poor environments. We collected 187 hours of data from three dyads (n = 6 individuals) of white-handed gibbons (Hylobates lar) living in a fruit-poor environment in western Thailand during the period of fruit scarcity. We calculated activity budgets, dyad behavioral synchronization, and dyad spatial cohesion. We hypothesized that activity budgets would differ significantly between sexes or pairs would engage in behaviors independently to provide females with an opportunity to obtain more resources. We also hypothesized that pairs would remain in close proximity. Overall, activity budgets exhibited significant variation when analyzed by sex (X2 = 27.693, ) and group (X2 = 119.584, ). Females spent less time resting and vocalizing and more time traveling compared to males. Percentages of synchronized behavior were lower than expected with only 55% of records synchronized (group B: 58.6%; group D: 58.5%; group L: 49.7%). Spatial cohesion, however, was relatively high overall with adults in the same or adjacent trees in 67.1% of paired records but significantly variable across groups (B: 89.4%; D: 73.1%; L: 48.2%; X2 = 190.111, ). We suggest that behavioral synchronization and spatial cohesion may be indicators of pair bond strength, not just the result of pair living. Given differences in activity budgets, low behavioral synchronization, and variable amounts of time pair mates spent apart, we conclude that pair mates should be considered individual actors who engage in behaviors independently from one another, particularly when coping with challenging ecological conditions.
An untapped resource: social media accounts show problem solving in numerous new animal species
Authors: Rowell Misha K. , Rymer Tasmin L. 
Published: October 2024

Abstract
Problem solving in animals is often studied by measuring an animal’s ability to solve man-made puzzles, such as puzzle feeders. Outside of scientific studies, puzzle feeders are also presented to captive animals housed in zoos, aquaria, and sanctuaries as a form of enrichment. Footage of these interactions is commonly posted on social media accounts to increase public engagement with the institution. However, because these puzzle feeders are not presented to animals for research purposes, the problem-solving abilities of numerous species may not be recorded in the scientific literature. Therefore, we searched through three social media platforms (Facebook, Instagram and X) for footage of captive animals solving problems to determine if social media could be a useful tool for behavioural scientists. For each video, we recorded what species was featured, what the puzzle was, how it was solved, and whether this was the first documentation of problem solving for the species (to the best of our knowledge). We found 111 records of successful problem solving across 74 species, including mammals (), birds (), and reptiles (). Overall, this was the first record of problem solving in 29 of these species. We suggest that social media could be a useful tool for researchers studying problem solving, particularly of mammalian and avian species.
The Houthi Movement in Context of the Religious and Tribal Situation in Yemen
Authors: Kuznetsov Alexander A. 
Published: October 2024

Abstract
This article examines the role of the religious and tribal factors in the genesis, development and expansion of the Houthi movement in Yemen. The relevance of this work stems from the transformation of the Ansarullah movement into the driver of not only domestic policy in Yemen but also of regional policy and the regional security situation. The article contains: a scrutiny of Zaydism as one of the leading religions in Yemen and its connection with the Houthi movement; the genesis of the Ansarullah movement and how it became dominant in Northern Yemen; and interrelations of this movement with the Yemeni tribes. The author of the article stipulates that from a religious point of view the Houthi movement reflects the teaching of traditional Zaydism and has its roots in Yemeni history, especially in the al-Mutawakkil Imamate. The article contains an analysis as to how the Houthis succeeded in neutralizing or exploiting the tribes of Yemen, taking into account that the tribal factor was a driver of political instability in the country. The author explains, in part, the success of the Houthis and their domination in conditions of war and conflicts (wars of Saada and the war against the Arabian coalition).
Hezbollah in Lebanon
Authors: Zreik Mohamad , Yazdani Enayatollah , Caba-Maria Flavius 
Published: October 2024

Abstract
This paper explores the evolution of Hezbollah following Israel’s 1982 invasion of Lebanon. Initially established to counter Israeli aggression and occupation, Hezbollah transitioned into a significant political and military entity in Lebanon post-2001. The organization has gained prominence as Lebanon’s leading political force, receiving substantial support from the Islamic Republic of Iran and adhering to the doctrine of Wilayat al-Faqih. Its transformation into a regional entity, coupled with a significant security role beyond Lebanon’s borders, has been noteworthy. However, Hezbollah’s dual existence as both a political party and an armed group has led to divergent perceptions internationally, with some Western governments labeling it a terrorist organization. The paper critically examines Hezbollah’s historical trajectory and delves into the ongoing debate over its dual roles, highlighting the internal conflicts and national controversies within Lebanon due to the concentration of military power in the hands of a single party.