bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochemistry and zircon U–Pb ages of basic rocks in the Kekebieketi mining area from Fuyun (Xinjiang, China) and their geological significance
Authors: Shao Tiequan , Hu Bo , Tang Hanhua , Shan Lihua , Jiang Kaituo , Jia Chenhui 
Published: March 2018

The Kekebieketi mining area is located on the southern margin of the Altai Mountains in Northern Xinjiang and is at the junction of the Siberia and Kazakhstan‐Junggar plates. Faults and magmatic rocks are well developed, and the main stratum is the Middle Devonian Kaxiweng Formation. The Kekebieketi‐Kalatongke‐Xibodu basic to ultrabasic mixed rock strip is an appropriate area for mineral resources and a good target to study the crustal and mantle evolution. This study explored the tectonic age and setting of basic rocks in the Kekebieketi mining area and provides a basis for the study of basic rocks and discrimination of the wider formation. The basic rocks were mainly gabbro, pyroxenolite, basic subvolcano rock, and diabase. They have all been altered to different degrees through amphibolization, sub‐amphibolization, actinolitization, chloritization, epidotization, zoisitization, uralitization, and serpentinization. Similar rare earth element compositions of the different rock types suggest that they are homologous. Enrichment of large ion lithophile elements (Cs, Rb, Sr, and U) and depletion of high field strength elements (Nb, Ta, Zr, and Hf) showed that the basic rocks have the characteristics of island arc magmatic rocks. A single zircon U–Pb age of 321 ± 2.5 Ma was obtained from a hornblende gabbro. Based on the petrological and geochemical features, we concluded that the basic rocks in the study area were formed during the post‐collision period in East Junggar. The parental magma is mainly composed of metasomatic mantle wedge material and upwelling asthenosphere, which is why it showed geochemical characteristics of subduction.
Dopamine D1 receptor‐mediated upregulation of BKCa currents modifies Müller cell gliosis in a rat chronic ocular hypertension model
Authors: Wu Hang‐Jing , Li Xue‐Yan , Qian Wen‐Jing , Li Qian , Wang Shu‐Yue , Ji Min , Ma Yuan‐Yuan , Gao Feng , Sun Xing‐Huai , Wang Xin , Miao Yanying , Yang Xiong‐Li , Wang Zhongfeng 
Published: March 2018

AbstractMüller cell gliosis is a common response in many retinal pathological conditions. We previously demonstrated that downregulation of Kir channels contributes to Müller cell gliosis in a rat chronic ocular hypertension (COH) model. Here, the possible involvement of outward K+ currents in Müller cell gliosis was investigated. Outward K+ current densities in Müller cells isolated from COH rats, as compared with those in normal rats, showed a significant increase, which was mainly contributed by large‐conductance Ca2+‐activated K+ (BKCa) channels. The involvement of BKCa channels in Müller cell gliosis is suggested by the fact that glial fibrillary acidic protein (GFAP) levels were augmented in COH retinas when these channels were suppressed by intravitreal injections of iberiotoxin. In COH retinas an increase in dopamine (DA) D1 receptor (D1R) expression in Müller cells was revealed by both immunohistochemistry and Western blotting. Moreover, protein levels of tyrosine hydroxylase were also increased, and consistent to this, retinal DA contents were elevated. SKF81297, a selective D1R agonist, enhanced BKCa currents of normal Müller cells through intracellular cAMP‐PKA signaling pathway. Furthermore, GFAP levels were increased by the D1R antagonist SCH23390 injected intravitreally through eliminating the BKCa current upregulation in COH retinas, but partially reduced by SKF81297. All these results strongly suggest that the DA‐D1R system may be activated to a stronger extent in COH rat retinas, thus increasing BKCa currents of Müller cells. The upregulation of BKCa channels may antagonize the Kir channel inhibition‐induced depolarization of Müller cells, thereby attenuating the gliosis of these cells.
Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta‐analysis
Authors: Vuong Huy Gia , Odate Toru , Duong Uyen N. P. , Mochizuki Kunio , Nakazawa Tadao , Katoh Ryohei , Kondo Tetsuo 
Published: March 2018

AbstractBackgroundSolid variant papillary thyroid carcinoma (SVPTC) is a rare variant of papillary thyroid cancer (PTC) and its prognostic value is still unclear. The purpose of this systematic clinical review and meta‐analysis is to investigate the prognostic value of SVPTC in comparison with classical PTC (cPTC).MethodsFour electronic databases, including PubMed, Scopus, Web of Science, and Virtual Health Library, were searched in June 2017. Extracted data were pooled into odds ratio (OR) or hazard ratio (HR) and their corresponding 95% confidence interval (CI) using the random‐effect model.ResultsFrom 1439 articles, we finally included 11 studies with 205 SVPTCs for meta‐analysis. Overall, SVPTC manifested a significantly higher risk for vascular invasion, tumor recurrence, and cancer mortality as compared to cPTC. The genetic profile of SVPTC was also distinct from that of cPTC.ConclusionA case of SVPTC should be regarded as an aggressive variant of PTC because of a higher risk for tumor recurrence and mortality.
Are malignant self‐regard and vulnerable narcissism different constructs?
Authors: Huprich Steven K. , Nelson Sharon , Sohnleitner Aimee , Lengu Ketrin , Shankar Sneha , Rexer Kyle 
Published: March 2018

AbstractIn the clinical and empirical literature, vulnerable narcissism and malignant self‐regard (MSR) have been found to be highly interrelated and associated with theoretically related personality constructs, suggesting that the two constructs may be much more similar than different. The present study set out to test this hypothesis by examining the relationship of vulnerable narcissism and MSR to experiences and expressions of anger, the factor structure of grandiose and vulnerable narcissism with MSR, the associations of MSR and vulnerable narcissism to the five factor model of personality, and to global self‐esteem in self‐report measures within 1168 undergraduate students. A separate study of 158 undergraduates also assessed how MSR and vulnerable narcissism predicted state and trait anxiety and anger after receiving positive or negative feedback, and the extent to which negative feedback interacted with MSR and vulnerable narcissism. Overall, compared with grandiose narcissism, both MSR and vulnerable narcissism were more associated with experiencing anger internally, self‐reports of state and trait anger, high levels of neuroticism and openness, and lower levels of extraversion and global self‐esteem. Both vulnerable narcissism and MSR uniquely predicted trait levels of anger and anxiety and state levels of anger after receiving negative feedback. It is concluded that MSR and vulnerable narcissism are likely identical constructs.
1‐Methylcyclopropene (1‐MCP) effects on natural disease resistance in stored sweet potato
Authors: Amoah Robert S , Terry Leon A 
Published: March 2018

AbstractBACKGROUNDThe potential of 1‐methylcyclopropene (1‐MCP) to maintain postharvest storage of sweet potato was studied. In two separate experiments, the orange‐fleshed sweet potato cv. Covington was treated with 1‐MCP (1.0 µL L−1, 24 h) and roots stored at 15 °C. During storage, samples were evaluated for the respiration rate, sprout growth, weight loss, incidence of decay and changes in dry matter. The roots were further assayed for the temporal changes in individual non‐structural carbohydrates and phenolic compounds in the skin and flesh tissues of the proximal (stem end), middle and distal (root end) regions.RESULTS1‐MCP treatment reduced root weight loss and decay but respiration rate and non‐structural carbohydrates were not affected. No sprouting was recorded irrespective of the treatment. 1‐MCP transiently suppressed the accumulation of individual phenolic compounds, especially in the middle and distal segments. This accentuated the proximal dominance of phenolic compounds. Isochlorogenic acid A and chlorogenic acid were the dominant phenolics in the skin and flesh tissues, respectively.CONCLUSION1‐MCP treatment may have an anti‐decay effect and reduce weight loss. Therefore, storage trials that involve the use of continuous ethylene supplementation to inhibit sprout growth may be combined with 1‐MCP to alleviate ethylene‐induced weight loss and decay in sweet potato. © 2018 Society of Chemical Industry
Effect of organic agronomic techniques and packaging on the quality of lamb's lettuce
Authors: Ceglie Francesco G , Amodio Maria Luisa , de Chiara Maria Lucia V , Madzaric Suzana , Mimiola Giancarlo , Testani Elena , Tittarelli Fabio , Colelli Giancarlo 
Published: March 2018

AbstractBACKGROUNDThis research focused on the effect of organic production systems on initial quality and postharvest performance of lamb's lettuce leaves stored in air or under modified atmosphere at refrigerated temperature. Different strategies of organic soil fertility management were compared under the same environmental conditions: (i) a simplified organic production system based on organic commercial fertilizers to recover crop uptake (SB); (ii) an organic production system based on organic matter amendment mainly supplied by animal manure (AM); and (iii) an organic production system based on organic matter amendment supplied by green waste compost (AC). Fully developed lamb's lettuce leaves were harvested and then packed into perforated bags (control in AIR) or in modified atmosphere packaging (MAP) and stored at 4 °C.RESULTSAt harvest, the yield of lamb's lettuce in the AM and AC systems was higher than that in SB. Phenol and dehydroascorbic acid accumulation was observed in the system with the lowest initial supply of organic amendment (SB). Regarding the effect of packaging, AIR conditions maintained the initial quality attributes for a longer period than MAP, which developed off‐odours above the threshold of acceptability at 11 days, irrespective of the production system used.CONCLUSIONIn general, the initial differences among the production systems were minimal during the postharvest storage. As for the tested packaging systems, AIR successfully maintained the initial quality attributes for a longer period than the MAP. © 2018 Society of Chemical Industry
Influence of cultivar and of conventional and organic agricultural practices on phenolic and sensory profile of blackberries (Rubus fruticosus)
Authors: Pinto Teresa , Vilela Alice , Pinto Andreia , Nunes Fernando M , Cosme Fernanda , Anjos Rosário 
Published: March 2018

AbstractBACKGROUNDConsumer demand for organic products is increasing because of their claimed health benefits. Blackberries are a rich source of polyphenols, with high antioxidant activity; nevertheless, the impact of organic versus conventional agricultural practices on its phytochemical composition is unknown. ‘Loch Ness’ and ‘Chester Thornless’ were selected as blackberry cultivars for this study because of their desired sensory and technological properties, which make them more suitable for export.RESULTS‘Loch Ness’ variety presented a higher amounts of polyphenols and higher antioxidant activity when compared to the ‘Chester Thornless’ variety. The impact of agricultural practices on the phytochemical composition of the two varieties was contradictory. Under organic agricultural practices, levels of polyphenols increased for ‘Loch Ness’ and decreased for ‘Chester Thornless’, whereas the soluble solids content increased in both varieties. These changes in composition were correlated with changes observed in the blackberries' sensory profile.CONCLUSIONThe effect of agricultural practices on the blackberries' chemical and sensory profile was dependent on the variety and cannot be generalized. © 2018 Society of Chemical Industry
Effect of substituting fresh‐cut perennial ryegrass with fresh‐cut white clover on bovine milk fatty acid profile
Authors: Stergiadis Sokratis , Hynes Deborah N , Thomson Anna L , Kliem Kirsty E , Berlitz Carolina GB , Günal Mevlüt , Yan Tianhai 
Published: March 2018

AbstractBACKGROUNDIncluding forage legumes in dairy systems can help address increasing environmental/economic concerns about perennial ryegrass monoculture pastures. This work investigated the effect of substituting fresh‐cut grass with increasing quantities of fresh‐cut white clover (WC) on milk fatty acid (FA) profile and transfer efficiency of dietary linoleic (LA) and α‐linolenic (ALNA) acids to milk fat. Three groups of three crossbred dairy cows were used in a 3 × 3 crossover design. Dietary treatments were 0 g kg−1 WC + 600 g kg−1 grass, 200 g kg−1 WC + 400 g kg−1 grass, and 400 g kg−1 WC + 200 g kg−1 grass. All treatments were supplemented with 400 g kg−1 concentrates on a dry matter basis. Cows had a 19‐day adaptation period to the experimental diet before a 6‐day measurement period in individual tie stalls.RESULTSIncreasing dietary WC did not affect dry matter intake, milk yield or milk concentrations of fat, protein or lactose. Milk polyunsaturated FA concentrations (total n‐3, total n‐6, LA and ALNA) and transfer efficiency of LA and ALNA were increased with increasing dietary WC supply.CONCLUSIONInclusion of WC in pastures may increase concentrations of nutritionally beneficial FA, without influencing milk yield and basic composition, but any implications on human health cannot be drawn. © 2018 The Authors. Journal of the Science of Food and Agriculture published by JohnWiley & Sons Ltd on behalf of Society of Chemical Industry.
Neutrophil‐lymphocyte ratio is associated with prognosis in patients who underwent potentially curative resection for gastric cancer
Authors: Szor Daniel José , Roncon Dias Andre , Pereira Marina A. , Ramos Marcus F.K.P. , Zilberstein Bruno , Cecconello Ivan , Ribeiro Ulysses 
Published: March 2018

Background and ObjectivesThe role of inflammation in cancer development is a well‐known phenomenon that may be represented by the neutrophil‐lymphocyte ratio (NLR). The present research intends to determine the impact of NLR on the survival outcome of patients with gastric cancer (GC), and to evaluate its use as a stratification factor for the staging groups.MethodsData regarding clinical characteristics, surgery, pathology, and follow‐up were retrospectively collected from our single‐center prospective database. Blood samples were obtained before surgery.ResultsA total of 383 patients (231 males) who underwent gastrectomy with lymphadenectomy were evaluated between 2009 and 2016. NLR established cutoff was 2.44, and patients were divided in NLR ≥2.44 (hNLR) and <2.44 (lNLR). hNLR patients (38.4% of the cases) had lower disease‐free survival and overall survival (OS) compared to lNLR patients (P = 0.047 and P = 0.045, respectively). Risk stratification according to NLR value was done in same tumor depth (T4 and <T4), stage (III and <III) and lymph node status (N+ and N−) group of patients. The OS was significantly lower when NLR was high in same tumor depth (P = 0.032) and stage (P = 0.020), but not in same lymph node status patients (P = 0.184). In a multivariate analysis, NLR was an independent factor of worse OS (HR 1.50 95%CI 1.27‐4.21, P = 0.048).ConclusionA high NLR was an independent risk factor for reduced survival in GC patients submitted to potentially curative resection. Calculating NLR is easily reproducible and may be incorporated in pre‐operative evaluation.
The impact of cultivated land spatial shift on food crop production in China, 1990–2010
Authors: Li Yuanyuan , Li Xiubin , Tan Minghong , Wang Xue , Xin Liangjie 
Published: March 2018

AbstractCultivated land has been undergoing significant spatial shift during the last 2 decades in China, according to land‐use data derived from the Landsat Thematic Mapper. Based on soil organic matter data and yield data at county level, we developed a constant crop yield dataset at pixel level with a resolution of 1 km. Using this dataset, this paper quantitatively evaluates average crop yield change due to cultivated land spatial shift at national and regional levels. The results show that (a) at national level, the average crop yield per unit area decreased by 1.99% during the period 1990–2010. The main reason for this is that built‐up areas occupied a significant amount of high‐yield cultivated land whereas low‐yield land converted in ecologically vulnerable areas. (b) In spite of 77.2 thousand km2 cultivated land was converted to built‐up areas, especially in areas with high economic value, such as Huang–Huai–Hai Plain, 329.4 thousand km2 land was converted to cultivated land, especially in Northeastern and Northwestern China. (c) The quality gap between cultivated land converted to built‐up areas nationally and new cultivated land regionally suggests that the loss of 1 km2 of cultivated land converted to built‐up area would, to achieve equivalency, need to be compensated by 1.54 km2 of new land in Xinjiang, or more in Northeastern China. However, cultivated land expansion in these areas may cause land degradation and a series of ecological environment problems.
Autonomic dysfunction in genetic forms of synucleinopathies
Authors: Chelban Viorica , Vichayanrat Ekawat , Schottlaende Lucia , Iodice Valeria , Houlden Henry 
Published: March 2018

ABSTRACTThe discovery of genetic links between alpha‐synuclein and PD has opened unprecedented opportunities for research into a new group of diseases, now collectively known as synucleinopathies. Autonomic dysfunction, including cardiac sympathetic denervation, has been reported in familial forms of synucleinopathies that have Lewy bodies at the core of their pathogenesis. SNCA mutations and multiplications, LRRK2 disease with Lewy bodies as well as other common, sporadic forms of idiopathic PD, MSA, pure autonomic failure, and dementia with Lewy bodies have all been associated with dysautonomia. By contrast, in familial cases of parkinsonism without Lewy bodies, such as in PARK2, the autonomic profile remains normal throughout the course of the disease. The degeneration of the central and peripheral autonomic systems in genetic as well as sporadic forms of neurodegenerative synucleinopathies correlates with the accumulation of alpha‐synuclein immunoreactive‐containing inclusions. Given that dysautonomia has a significant impact on the quality of life of sufferers and autonomic symptoms are generally treatable, a prompt diagnostic testing and treatment should be provided. Moreover, new evidence suggests that autonomic dysfunction can be used as an outcome prediction factor in some forms of synucleinopathies or premotor diagnostic markers that could be used in the future to define further research avenues. In this review, we describe the autonomic dysfunction of genetic synucleinopathies in comparison to the dysautonomia of sporadic forms of alpha‐synuclein accumulation and provide the reader with an up‐to‐date overview of the current understanding in this fast‐growing field. © 2018 International Parkinson and Movement Disorder Society
Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia
Authors: Mente Karin , Edwards Nancy A. , Urbano Demelio , Ray‐Chaudhury Abhik , Iacono Diego , Alho Ana Tereza Di Lorenzo , Alho Eduardo Joaquim Lopes , Amaro Edson , Horovitz Silvina G. , Hallett Mark 
Published: March 2018

ABSTRACTBackgroundThe etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in dystonia animal models and human imaging studies. Some animal models have cholinergic neuronal loss in the striatum and increased acetylcholinesterase activity in the pedunculopontine nucleus.ObjectivesThe objective of this study was to determine the presence of cholinergic abnormalities in the putamen and pedunculopontine nucleus in cervical dystonia human brain donors.MethodsFormalin‐fixed brain tissues were obtained from 8 cervical dystonia and 7 age‐matched control brains (controls). Pedunculopontine nucleus was available in only 6 cervical dystonia and 5 controls. Neurodegeneration was evaluated pathologically in the putamen, pedunculopontine nucleus, and other regions. Cholinergic neurons were detected using choline acetyltransferase immunohistochemistry in the putamen and pedunculopontine nucleus. Putaminal cholinergic neurons were quantified. A total of 6 cervical dystonia patients and 6 age‐matched healthy controls underwent diffusion tensor imaging to determine if there were white matter microstructural abnormalities around the pedunculopontine nucleus.ResultsDecreased or absent choline acetyltransferase staining was identified in all 6 pedunculopontine nucleus samples in cervical dystonia. In contrast, strong choline acetyltransferase staining was present in 4 of 5 pedunculopontine nucleus controls. There were no differences in pedunculopontine nucleus diffusion tensor imaging between cervical dystonia and healthy controls. There was no difference in numbers of putaminal cholinergic neurons between cervical dystonia and controls.ConclusionsOur findings suggest that pedunculopontine nucleus choline acetyltransferase deficiency represents a functional cholinergic deficit in cervical dystonia. Structural lesions and confounding neurodegenerative processes were excluded by absence of neuronal loss, gliosis, diffusion tensor imaging abnormalities, and beta‐amyloid, tau, and alpha‐synuclein pathologies. © 2018 International Parkinson and Movement Disorder Society
Predicting a successful outcome in sacral neuromodulation testing: Are urodynamic parameters prognostic?
Authors: Nobrega Richard P. , Solomon Eskinder , Jenks Julie , Greenwell Tamsin , Ockrim Jeremy 
Published: March 2018

AimsTo assess whether the urodynamic parameters of mean voided volume, peak detrusor overactivity (DO) pressure, bladder compliance, capacity, and volume at first detrusor overactivity during filling cystometry can predict a successful outcome at first stage tined lead placement (FSTLP).MethodsNinty‐nine consecutive patients with urodynamically proven idiopathic detrusor overactivity (IDO) refractory to medical treatment and opting for Sacral Nerve Stimulation (SNS), were assessed pre and post FSTLP. Data from 3‐day frequency‐volume charts, and patient reported (subjective) outcomes were used to assess success or failure after FSTLP. Success was defined as improvement in symptoms >50%. Binary logistic regression analysis was used to ascertain whether key parameters at filling cystometrogram were predictors for success prior to FSTLP.ResultsBinary logistic regression analysis did not demonstrate any significant relationship between the five parameters at urodynamics and outcome at FSTLP (B < 0.01, P > 0.16) for all parameters.ConclusionsThe results from this prospective analysis on patients with IDO refractive to medical therapy referred for SNS would suggest that aside from proving DO at urodynamics as a pre‐requisite for intervention as per NICE and EAU guidelines, no parameter is predictive for a successful outcome at FSTLP.