bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score
Authors: Onengut-Gumuscu Suna , Chen Wei-Min , Robertson Catherine C. , Bonnie Jessica K. , Farber Emily , Zhu Zhennan , Oksenberg Jorge R. , Brant Steven R. , Bridges S. Louis , Edberg Jeffrey C. , Kimberly Robert P. , Gregersen Peter K. , Rewers Marian J. , Steck Andrea K. , Black Mary H. , Dabelea Dana , Pihoker Catherine , Atkinson Mark A. , Wagenknecht Lynne E. , Divers Jasmin , Bell Ronny A. ,   SEARCH for Diabetes in Youth,   Type 1 Diabetes Genetics Consortium, Erlich Henry A. , Concannon Patrick , Rich Stephen S. 
Published: January 2019

OBJECTIVE
Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated with type 1 diabetes risk in African-ancestry participants and develops an African-specific GRS.

RESEARCH DESIGN AND METHODS
We generated single nucleotide polymorphism (SNP) data with the ImmunoChip on 1,021 African-ancestry participants with type 1 diabetes and 2,928 control participants. HLA class I and class II alleles were imputed using SNP2HLA. Logistic regression models were used to identify genome-wide significant (P &lt; 5.0 × 10−8) SNPs associated with type 1 diabetes in the African-ancestry samples and validate SNPs associated with risk in known European-ancestry loci (P &lt; 2.79 × 10−5).

RESULTS
African-specific (HLA-DQA1*03:01-HLA-DQB1*02:01) and known European-ancestry HLA haplotypes (HLA-DRB1*03:01-HLA-DQA1*05:01-HLA-DQB1*02:01, HLA-DRB1*04:01-HLA-DQA1*03:01-HLA-DQB1*03:02) were significantly associated with type 1 diabetes risk. Among European-ancestry defined non-HLA risk loci, six risk loci were significantly associated with type 1 diabetes in subjects of African ancestry. An African-specific GRS provided strong prediction of type 1 diabetes risk (area under the curve 0.871), performing significantly better than a European-based GRS and two polygenic risk scores in independent discovery and validation cohorts.

CONCLUSIONS
Genetic risk of type 1 diabetes includes ancestry-specific, disease-associated variants. The GRS developed here provides improved prediction of type 1 diabetes in African-ancestry subjects and a means to identify groups of individuals who would benefit from immune monitoring for early detection of islet autoimmunity.
Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial
Authors: Callaway Leonie K. , McIntyre H. David , Barrett Helen L. , Foxcroft Katie , Tremellen Anne , Lingwood Barbara E. , Tobin Jacinta M. , Wilkinson Shelley , Kothari Alka , Morrison Mark , O’Rourke Peter , Pelecanos Anita , Dekker Nitert Marloes 
Published: January 2019

OBJECTIVE
Given the role of gut microbiota in regulating metabolism, probiotics administered during pregnancy might prevent gestational diabetes mellitus (GDM). This question has not previously been studied in high-risk overweight and obese pregnant women. We aimed to determine whether probiotics (Lactobacillus rhamnosus and Bifidobacterium animalis subspecies lactis) administered from the second trimester in overweight and obese women prevent GDM as assessed by an oral glucose tolerance test (OGTT) at 28 weeks’ gestation. Secondary outcomes included maternal and neonatal complications, maternal blood pressure and BMI, and infant body composition.

RESEARCH DESIGN AND METHODS
This was a double-blind randomized controlled trial of probiotic versus placebo in overweight and obese pregnant women in Brisbane, Australia.

RESULTS
The study was completed in 411 women. GDM occurred in 12.3% (25 of 204) in the placebo arm and 18.4% (38 of 207) in the probiotics arm (P = 0.10). At OGTT, mean fasting glucose was higher in women randomized to probiotics (79.3 mg/dL) compared with placebo (77.5 mg/dL) (P = 0.049). One- and two-hour glucose measures were similar. Preeclampsia occurred in 9.2% of women randomized to probiotics compared with 4.9% in the placebo arm (P = 0.09). Excessive weight gain occurred in 32.5% of women in the probiotics arm (55 of 169) compared with 46% in the placebo arm (81 of 176) (P = 0.01). Rates of small for gestational age (&lt;10th percentile) were 2.4% in the probiotics arm (5 of 205) and 6.5% in the placebo arm (13 of 199) (P = 0.042). There were no differences in other secondary outcomes.

CONCLUSIONS
The probiotics used in this study did not prevent GDM in overweight and obese pregnant women.
Quantification of acute parasympathetic denervation during cryoballoon ablation by using extracardiac vagal stimulation
Authors: Osório Thiago Guimarães , Coutiño Hugo-Enrique , Iacopino Saverio , Sieira Juan , Ströker Erwin , Martín-Sierra Cristina , Salghetti Francesca , Paparella Gaetano , Aryana Arash , Varnavas Varnavas , Terasawa Muryo , Brugada Pedro , de Asmundis Carlo , Chierchia Gian-Battista 
Published: January 2019

Aims
The purpose of this study was to systematically quantify the level of acute parasympathetic denervation in a stepwise fashion by means of extracardiac vagal stimulation (ECVS) by positioning a quadripolar catheter in the internal jugular vein, in a cohort of patients undergoing second-generation cryoballoon ablation for paroxysmal atrial fibrillation.

Methods
Fifty patients with symptomatic paroxysmal atrial fibrillation, having undergone extracardiac vagal stimulation before and after ablation by means of second-generation cryoballoon second-generation cryoballoon ablation, were included.

Results
The extracardiac vagal stimulation performed preablation provoked cardioinhibitory responses in all patients with mean pause duration of 10130.6 ± 3280.0 ms. At the end of the procedure, the VRs were significantly diminished with mean pause of 1687.5 ms ± 2183.7 ms (P = 0.00 compared with the pause before the procedure).

Conclusion
The ECVS proved to be a reproducible, feasible and reliable method to quantify the degree of parasympathetic denervation during CB-A. In all patients, significant cardiac parasympathetic denervation could be observed at the end of the procedure. Responses to ECVS were more specific to quantify the vagal denervation than the increase in the heart rate. However larger studies are needed to confirm this observation.
Evaluation of skin turgor and capillary refill time as predictors of dehydration in exercising dogs
Authors: Goucher Taylor K. , Hartzell Alexandra M. , Seales Tessa S. , Anmuth Abigail S. , Zanghi Brian M. , Otto Cynthia M. 
Published: January 2019

Abstract
OBJECTIVE To determine usefulness of skin turgor and capillary refill time (CRT) for predicting changes in hydration status of working dogs after a 15-minute exercise period.
ANIMALS 9 exercise-conditioned working dogs between 8 and 108 months of age.
PROCEDURES Skin tent time (SkTT; time for tented skin on the forehead to return to an anatomically normal position) and CRT (time for occluded mucous membrane capillary vessels to return to the color visible before occlusion) were measured on dogs in a field setting and by video review. Body weight (BW), SkTT, CRT, and core body temperature were measured before and after a 15-minute exercise period. Exercise challenge was performed on days 1 and 8.
RESULTS Time (day 1 vs day 8) did not significantly affect results; therefore, data were pooled for the 2 trial days. Mean ± SE BW decreased (but not significantly) by 0.83 ± 0.27% after exercise. The SkTT increased significantly (both field setting and video review) after exercise. Correlation between SkTT results for the field setting and video review (r = 0.68) was significant. The CRT decreased (but not significantly) after exercise.
CONCLUSIONS AND CLINICAL RELEVANCE Dogs became mildly dehydrated (mean BW loss, 0.83%) during a 15-minute exercise period, and the mild dehydration was evident as a visually detectable change in skin turgor. Monitoring the SkTT appeared to be a useful strategy for predicting small shifts in hydration status of dogs during exercise. The CRT decreased and was not a significant predictor of a change in hydration status.
Design and FPGA implementation of 11th order Efficient IIR Wavelet Filter Banks with Approximate Linear-phase
Authors: Hamad Rasha W. 
Published: January 2019

In this paper. Bireciprocal Lattice Wave Digital Filters (BLWDFs) are utilized in an approximate linear-phase in pass-band design of order IIR wavelet filter banks (FBs). These filter banks are efficiently designed by replacement one of branches for (BLWDFs) by only a unit delay. The coefficients of the designed filter are achieved by simulating the IIR response suggested in [1]. The design is first simulated using Matlab programming in order to investigate the resulting wavelet filter properties and to find the suitable wordlength for the BLWDFs coefficients. FPGA implemtation of the proposed IIR wavelet filter bank is also achived for three levels with less complexity and high operating frequency.
Petrography and geochemistry of coarse-crystalline veins within Vredefort Granophyre, Vredefort impact structure, South Africa
Authors: Kovaleva E. , Huber M.S. , Zaccarini F. 
Published: January 2019

Abstract
Vredefort Granophyre dykes are generally considered to be a part of impact melt, which intruded downward from the melt sheet of the Vredefort impact structure (South Africa). This work reports enigmatic textural inhomogeneities found within the Daskop and southeast Holfontein granophyre dykes located in the core of the Vredefort impact structure, and in the Kopjeskraal core-collar granophyre dyke. The heterogeneities attributed to the clast-rich dykes (up to 70 vol% of clasts), however, do not occur within the portions of high clast abundance in these dykes. Instead, they are found within dyke portions with 5 to 10 vol% of clasts. They were not observed in the clast-poor northwest Holfontein dyke. The reported heterogeneities are veins with macroscopically straight and sharp boundaries that are parallel to the strike of the host dyke. The veins are usually from 4 to 20 cm wide and are often differentially eroded with respect to the host rock.
Microscopic analyses demonstrate that the veins are coarser-grained than the host granophyre, with the increase in grain size of at least four times. Portable μ-XRF, whole rock WD-XRF and microprobe analyses indicate practically identical composition of the veins to the host granophyre. Slightly higher Ab and K mole % values of plagioclase and Fe-enriched rims of orthopyroxene within the veins suggest lower crystallization temperatures of the veins and/or crystallization over a longer period of time.
We interpret the coarse-grained veins as either pegmatitic, typical for felsic intrusive rocks, or being similar to coarse-grained segregation veins reported from basaltic flows, both of which would normally involve late, volatile-enriched residual melts. In either case, the veins probably formed with comparatively small volatile component (≤1 wt% of water) derived from the wall rocks and from the incorporated lithic clasts. The main implication of our study is that the granophyre dykes are inhomogeneous and complicated formations, which contrasts with previous reports. Additionally, we report for the first time that the composition of the granophyre is corresponding to dacite.
A Manual Therapy and Home Stretching Program in Patients With Primary Frozen Shoulder Contracture Syndrome: A Case Series
Authors: Dueñas Lirios , Balasch-Bernat Mercè , Aguilar-Rodríguez Marta , Struyf Filip , Meeus Mira , Lluch Enrique 
Published: January 2019

Background Manual therapy has been demonstrated to reduce pain and improve function in patients with frozen shoulder contracture syndrome (FSCS), but no evidence exists to support one form of manual therapy over another. This case series describes both short- and long-term outcomes after a manual therapy program and home stretching exercises based on specific impairments in shoulder mobility and level of tissue irritability in patients with FSCS. Case Description Eleven patients with primary FSCS were treated with an individually tailored, multimodal manual therapy approach once weekly for 12 visits, coupled with home stretching exercises once a day, 5 days per week. Pain, disability, range of motion (ROM), and muscle strength of the affected shoulder were assessed at baseline, posttreatment, at 6 months, and at 9 months. Outcomes Significant improvements in self-reported pain, disability, shoulder ROM, and strength were reported following treatment. Additionally, 4 of 11 patients showed pain improvements that exceeded the minimal clinically important difference (MCID) on the visual analog scale postintervention, and 8 of 11 showed pain improvements at 6 and 9 months. Moreover, 7 of 11 patients showed improvements in Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire scores exceeding the MCID postintervention and at 6 months, and 8 of 11 exceeded the MCID at 9 months. Discussion Clinically meaningful changes in shoulder pain and disability, ROM, or muscle strength were observed in 11 patients with primary FSCS treated with an individually tailored approach of both manual therapy techniques and stretching exercises, accounting for tissue irritability. Level of Evidence Therapy, level 5. J Orthop Sports Phys Ther 2019;49(3):192–201. Epub 18 Jan 2019. doi:10.2519/jospt.2019.8194
Ultrasound-Guided Percutaneous Electrical Nerve Stimulation of the Radial Nerve for a Patient With Lateral Elbow Pain: A Case Report With a 2-Year Follow-up
Authors: Arias-Buría José L. , Cleland Joshua A. , El Bachiri Youssef R. , Plaza-Manzano Gustavo , Fernández-de-las-Peñas César 
Published: January 2019

Background Patients with lateral elbow pain are often diagnosed with lateral epicondylalgia. Lateral elbow pain is often associated with dysfunction of the wrist extensor muscles; however, in some cases, it can also mimic signs and symptoms of radial nerve dysfunction. Case Description In this case report, a 43-year-old man, who was originally referred with a diagnosis of lateral epicondylalgia as a result of playing table tennis and who previously responded favorably to manual therapy and exercise, presented to the clinic for treatment. An exacerbation while participating in a table tennis match resulted in a return of his lateral epicondylalgia symptoms, which did not respond favorably to the same interventions used in his prior course of therapy. Further examination revealed sensitization of the radial nerve, which was treated with 2 sessions of ultrasound-guided percutaneous electrical nerve stimulation and 4 weeks of a low-load, concentric/eccentric exercise program for the wrist extensors. Outcomes Following this intervention, the patient experienced clinically meaningful improvement in pain intensity (numeric pain-rating scale), function (Patient-Rated Tennis Elbow Evaluation), and related disability (Disabilities of the Arm, Shoulder and Hand questionnaire). The patient progressively exhibited complete resolution of pain and function, which was maintained at 2 years. Discussion This case report demonstrates the outcomes of a patient with lateral elbow pain who did not respond to manual therapy and exercise. Once radial nerve trunk sensitivity was identified and the intervention, consisting of ultrasound-guided percutaneous electrical nerve stimulation targeting the radial nerve combined with a low-load exercise program, was applied, a full resolution of pain and function occurred rapidly. Future clinical trials should examine the effect of percutaneous electrical nerve stimulation in the management of nerve-related symptoms associated with musculoskeletal pain conditions. Level of Evidence Therapy, level 5. J Orthop Sports Phys Ther 2019;49(5):347–354. Epub 18 Jan 2019. doi:10.2519/jospt.2019.8570
The Impact of Decreased Scapulothoracic Upward Rotation on Subacromial Proximities
Authors: Lawrence Rebekah L. , Braman Jonathan P. , Ludewig Paula M. 
Published: January 2019

Background Decreased scapulothoracic upward rotation has been theorized to increase an individual's risk for rotator cuff compression by reducing the clearance for the tendons in the subacromial space (ie, subacromial proximities). However, the impact of decreased scapulothoracic upward rotation on subacromial proximities has not been tested during dynamic in vivo shoulder motion. Objective To determine the impact of decreased scapulothoracic upward rotation on subacromial proximities. Methods Shoulder kinematics were quantified in 40 participants, classified as having high or low scapulothoracic upward rotation, during scapular plane abduction using single-plane fluoroscopy and 2-D/3-D shape-matching. Subacromial proximities were calculated as (1) the normalized minimum distance between the coracoacromial arch and humeral rotator cuff insertion, and (2) the surface area of the humeral rotator cuff insertion in immediate proximity to the coracoacromial arch. The effect of decreased scapulothoracic upward rotation on subacromial proximities was assessed using 2-factor mixed-model analyses of variance. The prevalence of contact between the coracoacromial arch and rotator cuff was also quantified. Results Subacromial distances were generally smallest below 70° of humerothoracic elevation. With the arm at the side, the normalized minimum distance for participants in the low scapulothoracic upward rotation group was 34.8% smaller compared to those in the high upward rotation group (P = .049). Contact between the coracoacromial arch and rotator cuff tendon occurred in 45% of participants. Conclusion Decreased scapulothoracic upward rotation shifts the range of risk for subacromial rotator cuff compression to lower angles. However, the low prevalence of contact suggests that subacromial rotator cuff compression may be less common than traditionally presumed. J Orthop Sports Phys Ther 2019;49(3):180–191. Epub 18 Jan 2019. doi:10.2519/jospt.2019.8590
The Epidemiology of Low Back Pain and Injury in Dance: A Systematic Review
Authors: Swain Christopher T.V. , Bradshaw Elizabeth J. , Ekegren Christina L. , Whyte Douglas G. 
Published: January 2019

Background Dance is a physical pursuit that involves loading the spine through repetitive dynamic movements and lifting tasks. As such, low back pain (LBP) and low back injury (LBI) have been identified as common health problems in contemporary and classical ballet dancers. However, clarity regarding the experience of LBP and LBI in dance is lacking. Objectives To systematically review and synthesize the epidemiology of LBP and LBI in dance populations. Methods A comprehensive search of 6 electronic databases, back catalogs of dance science–specific journals, and reference lists of relevant articles and a forward citation search were performed. Results Fifty full-text articles were included in the final systematic review. There was considerable methodological heterogeneity among the included studies. The median (range) point, yearly, and lifetime prevalence of LBP was 27% (17%–39%), 73% (41%–82%), and 50% (17%–88%), respectively. The lower back contributed to 11% (4%–22%) of time loss and 11% (5%–23%) of medical-attention injuries. Conclusion Dancers are vulnerable to LBP and LBI. The use of definitions that are sensitive to the complexity of LBP and LBI would facilitate improved understanding of the problem within dance, inform health care strategies, and allow for monitoring LBP-specific intervention outcomes. J Orthop Sports Phys Ther 2019;49(4):239–252. Epub 18 Jan 2019. doi:10.2519/jospt.2019.8609
PENINGKATAN KEMAMPUAN MANAJEMEN WIRAUSAHA UNTUK PEDAGANG KAKI LIMA DI LINGKUNGAN KAMPUS UNISBA
Authors: Amaranti Reni , Nugraha Nugraha , Nurrahman Ahmad Arif , Dzikron M 
Published: January 2019

Keberadaan para pedagang kaki lima yang berjualan di sekitar kampus unisba saat ini sedikit mengganggu kenyamanan dan kebersihan lingkungan kampus. Walaupun demikian, keberadaan pedagang kaki lima tersebut telah memberikan alternatif bagi mahasiswa Unisba untuk mendapatkan makanan dan minuman selain di kantin kampus atau di koperasi mahasiswa. Pengamatan awal menunjukkan bahwa cara berdagang yang mereka lakukan tidak berubah dari waktu ke waktu, padahal mereka sudah berjualan bertahun-tahun bahkan puluhan tahun. Manajemen usaha yang sangat sederhana menyebabkan usaha tidak berkembang secara signifikan. Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatan kemampuan manajemen wirausaha dari para pedagang kaki lima tersebut sehingga mereka dapat mengelola usahanya dengan lebih baik dan usahanya dapat berkembang secara signifikan.Pengabdian pada masyarakat ini dilakukan dengan memberikan pelatihan dan pendampingan mengenai manajemen usaha, meliputi manajemen produksi, manajemen keuangan sederhana, manajemen produksi, dan pemasaran. Untuk mengurangi kejenuhan peserta pelatihan, pelatihan tidak dilakukan dalam kelas. Selain itu juga dilakukan inisiasi pembentukan paguyuban pedagang untuk memudahkan koordinasi dan komunikasi antar pedagang atau antara pedagang dengan pihak lain. Hasil kegiatan ini menunjukkan bahwa terjadi peningkatan pada pemahaman para pedagang mengenai cara mengelola usaha mereka dan sebagian besar peserta pelatihan merasa puas dengan pelaksanaan pelatihan yang dilakukan. Para pedagang mengharapkan kegiatan serupa dilakukan secara rutin dengan materi pelatihan yang berbeda sehingga kemampuan mereka semakin bertambah.
PERANCANGAN ULANG KURSI KULIAH YANG ERGONOMIS DI UNIVERSITAS ISLAM BANDUNG JL. TAMANSARI NO.1 BANDUNG
Authors: Achiraeniwati Eri , Rejeki Yanti Sri , As'ad Nur Rahman , Pratama Widi 
Published: January 2019

Universitas Islam Bandung (Unisba), merupakan salah satu universitas swasta yang berada di Bandung Jawa Barat. Unisba memiliki visi “ Menjadi Perguruan Tinggi Islam yang mandiri, dan terkemuka di Asia”. Salah satu upaya dalam mewujudkan visi tersebut adalah dengan meningkatkan kualitas pembelajaran. Kualitas belajar yang baik dapat dipengaruhi oleh faktor lingkungan fisik kelas. Setiap ruang kelas yang ada di Universitas Islam Bandung (Unisba) telah dilengkapi fasilitas pembelajaran sebagai sarana pendukung dalam proses pembelajaran. Fasilitas yang tersedia terdiri dari kursi kuliah, papan tulis, layar proyektor dan lingkungan kelas. Fasilitas tersebut masih dirasakan kurang nyaman, khususnya pada kelas yang berada di Jl. Tamansari No.1. Berdasarkan hasil kuesioner mengenai fasilitas kelas yang dirasakan belum nyaman dan perlu diperbaiki terhadap 40 mahasiswa, yang terdiri dari 11 mahasiswa Fakultas Psikologi, 9 mahasiswa Fakultas Teknik, 8 mahasiswa Fakultas Ekonomi, dan 12 mahasiswa Fakultas Komunikasi, menunjukan bahwa fasilitas yang paling dirasakan belum nyaman dan perlu diperbaiki adalah kursi kuliah. Oleh karena itu perlu dilakukan perancangan ulang terhadap kursi kuliah di Unisba dengan memperhatikan keinginan pengguna dan aspek ergonomis. Metode yang digunakan untuk penelitian ini adalah metode Ergonomic Function Deployment (EFD) dan Antropometri. Data yang digunakan dalam penelitian ini diperoleh dengan cara menyebarkan kuesioner Nordic body Map untuk mengetahui keluhan yang dirasakan oleh mahasiswa terhadap penggunaan kursi kuliah, kuesioner keinginan mahasiswa terhadap kursi kuliah, dan pengukuran dimensi tubuh untuk memperoleh ukuran kursi kuliah yang sesuai dengan ukuran mahasiswa. Jumlah responden sebanyak 98 responden, yang mewakili Fakultas Psikologi, Teknik, Ekonomi dan Komunikasi. Hasil dari penelitian ini adalah rancangan kursi kuliah yang sesuai dengan keinginan dan ukuran tubuh mahasiswa pengguna kursi kuliah yang ada di Kampus Unisba Jl. Tamansari No. 1.