bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting and Enabling Scholarship: Developing and Sharing Expertise in Online Learning and Teaching
Authors: Barnes Fiona , Cole Sue , Nix Ingrid 
Published: May 2018

In a highly competitive, rapidly changing higher education market, universities need to be able to generate pedagogical expertise quickly and ensure that it is applied to practice. Since teaching approaches are constantly evolving, partly responding to emerging learning technologies, there is a need to foster ways to keep abreast on an ongoing basis. This paper explores how a small-scale project, the Teaching Online Panel (TOP), used scholarship investigations and a bottom-up approach to enhance one particular aspect of academic practice – online learning and teaching. The experiences of TOP are useful for identifying:

how a scholarship approach can help develop academic expertise
its contribution to enhancing understanding of staff’s different roles in the University
ways of developing the necessary supportive network for those undertaking such scholarship
the effectiveness of staff development which is peer-led rather than imposed from above
how practical examples can stimulate practice development
the relevance of literature on communities of practice and landscapes of practice for scholarship
the important role of ‘brokers’ to facilitate the dissemination of scholarship findings
the benefits to the brokers’ own professional roles
the challenges of sustaining such an approach and lessons learnt.

This study has relevance for those involved in supporting scholarship or delivering staff development in Higher Education.
Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control
Authors: Anaclet Christelle , De Luca Roberto , Venner Anne , Malyshevskaya Olga , Lazarus Michael , Arrigoni Elda , Fuller Patrick M. 
Published: May 2018

Recent studies have identified an especially important role for basal forebrain GABAergic (BFVGAT) neurons in the regulation of behavioral waking and fast cortical rhythms associated with cognition. However, BFVGATneurons comprise several neurochemically and anatomically distinct subpopulations, including parvalbumin-containing BFVGATneurons and somatostatin-containing BFVGATneurons (BFSOMneurons), and it was recently reported that optogenetic activation of BFSOMneurons increases the probability of a wakefulness to non-rapid-eye movement (NREM) sleep transition when stimulated during the rest period of the animal. This finding was unexpected given that most BFSOMneurons are not NREM sleep active and that central administration of the synthetic somatostatin analog, octreotide, suppresses NREM sleep or increases REM sleep. Here we used a combination of genetically driven chemogenetic and optogenetic activation, chemogenetic inhibition, and ablation approaches to further explore thein vivorole of BFSOMneurons in arousal control. Our findings indicate that acute activation or inhibition of BFSOMneurons is neither wakefulness nor NREM sleep promoting and is without significant effect on the EEG, and that chronic loss of these neurons is without effect on total 24 h sleep amounts, although a small but significant increase in waking was observed in the lesioned mice during the early active period. Ourin vitrocell recordings further reveal electrophysiological heterogeneity in BFSOMneurons, specifically suggesting at least two distinct subpopulations. Together, our data support the more nuanced view that BFSOMneurons are electrically heterogeneous and are not NREM sleep or wake promoting per se, but may exert, in particular during the early active period, a modest inhibitory influence on arousal circuitry.SIGNIFICANCE STATEMENTThe cellular basal forebrain (BF) is a highly complex area of the brain that is implicated in a wide range of higher-level neurobiological processes, including regulating and maintaining normal levels of electrocortical and behavioral arousal. The respectivein vivoroles of BF cell populations and their neurotransmitter systems in the regulation of electrocortical and behavioral arousal remains incompletely understood. Here we seek to define the neurobiological contribution of GABAergic somatostatin-containing BF neurons to arousal control. Understanding the respective contribution of BF cell populations to arousal control may provide critical insight into the pathogenesis of a host of neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia, and the cognitive impairments of normal aging.
Adolescent Consumption of Sports Drinks
Authors: Cordrey Kyla , Keim Sarah A. , Milanaik Ruth , Adesman Andrew 
Published: May 2018

BACKGROUND:
Sports drinks are aggressively marketed to teenagers to replenish fluids and/or electrolytes. According to the American Academy of Pediatrics, typical adolescent physical activity does not require sports drink rehydration. Given US obesity rates and that sugar-sweetened sports drinks add superfluous calories to the diet, it is important to assess adolescent sports drink consumption and changes over time.

METHODS:
Researchers in the 2015 Youth Risk Behavior Survey and 2010 National Youth Physical Activity and Nutrition Survey collected nationally representative samples of US high school students about sports drink consumption. Respondent characteristics and health behaviors were examined relative to sports drink consumption by using multivariable survey logistic regression. χ2 tests were used to compare the 2 samples and examine changes over time.

RESULTS:
The 2015 Youth Risk Behavior Survey and 2010 National Youth Physical Activity and Nutrition Survey had national samples of 15 624 and 11 458 respondents, respectively. Sports drink consumption in the previous week increased from 56% (2010) to 57.6% (2015; P = .0002). However, comparisons of daily sports drink consumption revealed reductions for all age groups, sexes, race and/or ethnicity categories, and levels of physical activity. The greatest reductions were for non-Hispanic African Americans and for children with overweight. Daily sports drink consumption did not decrease for children with obesity and increased for children who watched &gt;2 hours per day of television. In 2015, boys, non-Hispanic African Americans, Hispanics, and tobacco users exhibited higher odds of consuming sports drinks daily.

CONCLUSIONS:
Although daily consumption of sports drinks has decreased overall, sugar-sweetened sports drinks remain popular, with the majority of high school students drinking them at least weekly. Of concern, daily consumption increased among teenagers watching television &gt;2 hours per day. Pediatricians should counsel adolescents about the American Academy of Pediatrics’ recommendations regarding sports drinks.
Tüdőlebeny-eltávolítást követő kemoterápia tolerabilitását befolyásoló perioperatív tényezők
Authors: Ottlakán Aurél , Pécsy Balázs , Csada Edit , Ádám Gábor , Maráz Anikó , Borda Bernadett , Lázár György , Furák József 
Published: May 2018

Abstract: Introduction: Lung cancer is the leading cause of malignancy-related deaths in Hungary, involving complex surgical and oncological treatment. Aim: Factors influencing the tolerability of complete/planned and incomplete postoperative chemotherapy after surgery were analyzed. Method: During a 6-year period (January 1, 2011–December 31, 2016), data of 72 patients operated with lung cancer (adenocarcinoma and squamous cell carcinoma), receiving complete (4 cycles) and incomplete (<4 cycles) postoperative chemotherapy were analyzed. The following factors among the two groups [complete: n = 53; incomplete: n = 19] were analyzed: gender, mean age, body mass index, Malnutrition Universal Screening Tool, Charlson Comorbidity Index, second malignant tumor, atrial fibrillation, Forced Expiratory Volume 1 sec, Performance Status, open/Video-Assisted Thoracic Surgery (VATS) lobectomy, duration of surgery, postoperative fever, need for transfusion, prolonged air leak, redo surgery, histology, tumor stage. Results: The rate of complete postoperative cycles obtained from logistic regression analysis, were substantially higher after VATS lobectomies [n = 26 (83.87%)] compared to open procedures [n = 27 (65.85%)]; (p = 0.092; OR = 0.356), without significance. Multivariate analysis (open/VATS lobectomy, upper/middle-lower lobe resection, diabetes, prolonged air leak, postoperative fever) showed significantly increased successful uptake of complete cycles after VATS (p = 0.0495), while upper/middle lobe resections (p = 0.0678) and the lack of diabetes (p = 0.0971) notably increased the number of complete cycles, without significance. Conclusion: Twenty-six percent of patients were unable to receive complete planned postoperative chemotherapy. VATS lobectomy patients received significantly higher number of complete cycles of postoperative chemotherapy. Diabetes and lower lobe lobectomies had a negative effect on the tolerability of postoperative chemotherapy. Orv Hetil. 2018; 159(19): 748–755.
Colorectalis daganatokban a 2-es típusú cukorbetegség és a thrombocytosis előfordulása, a túlélésre gyakorolt hatásuk, a primer tumor műtéti eltávolítása előtt és után
Authors: Herold Zoltán , Ambrus Viktória , Herold Magdolna , Herczeg György , Igaz Péter , Harsányi László , Somogyi Anikó 
Published: May 2018

Abstract: Introduction: The relationship between platelets and metastatic tumor cells is an ongoing research area. Pre- and postoperative thrombocytosis are suggested predictive survival markers. Colorectal cancer and type 2 diabetes are characterized by various changes to platelets. The occurrence of colorectal cancer is more frequent in diabetes. Aim: Our aim was to determine the occurrence of type 2 diabetes in colorectal cancer patients, who attended the Semmelweis University 2nd Department of Internal Medicine’s Oncology Department in the last three years. Further goals included the evaluation of anamnestic, pre- and postoperative laboratory data, and whether diabetes can be a significant survival factor. Method: A retrospective study was conducted with 86 randomly selected colorectal cancer patients’ preoperative (86 patients) and paired postoperative (66, who were operable) data. Patients were monitored no later than September 30, 2017 or until their death. Results: Preoperatively, elevated (over 400 Giga/L) platelet counts were present in 22.1% of the patients (323.5 ± 128.63 Giga/L, mean ± SD) which decreased to 10.6% postoperatively (χ2: p = 0.0351; 289.2 ± 82.45 Giga/L, p = 0.0232). Negative correlation was found between platelet counts and overall survival (R: –0.35, p = 0.0085). One third of the patients had diabetes. Laboratory results (i.e., blood counts, creatinine) between diabetic and non-diabetic patients were not significant. Diabetes is a significant five-fold postoperative risk factor for shorter overall survival (relative risk: 5.1612, p = 0.0165). Average survival was 30.6 ± 26.78 months. Conclusion: Persistent consequential postoperative thrombocytosis may indicate shorter survival time. Our observations suggest elevated platelet counts and type 2 diabetes as prognostic markers for survival at the recognition of colorectal tumors. Orv Hetil. 2018; 159(19): 756–767.
Profil saliva pada penyirih di Kecamatan Rembon Kabupaten Tana Toraja Salivary profile of betel quid tobacco chewers in District of Rembon, Tana Toraja
Authors: Marcelina Marcelina , Samad Rasmidar 
Published: May 2018

Betel quid tobacco (BQT) chewing is a process of chewing betel leaves, areca nut, lime, gambier, and tobacco. Chewing and chemical stimulation of BQT can affect the salivary profile. The purpose of this study is to observe the differences of salivary profile such as volume, pH, and salivary inorganic component (Na + and phosphate) between BQT chewers and non-chewers. This study is an observation analytic with cross sectional design on 30-60 years old women that live in Rembon district of Tana Toraja (n=96) using cluster random sampling technique. Salivary volume was measured by measured glass, salivary pH was measured by indicator pH (Macherey-Nagel). The content of the salivary inorganic component was seen using atomic absorption spectrophotometer in BPTP Laboratory, Maros. Data were analyzed by t-test and chi square test using SPSS v 15.0. The result were mean of salivary volume (chewers=3.88 ml/10 s; p=0.051). Mean of salivary pH (chewers=6.92; p=0.001). Mean of salivary Na+ (chewers=0.38 ppm; p=0.112), Mg2+ (chewers=11.9 ppm; p=0.002), phosphate (chewers=156.8 ppm; p=0.001), Ca 2+ (chewers=174.8 ppm; p=0.000), K concluded that there was no significant difference on salivary volume, pH, Na+, K+, Ca2+, Mg(chewers=445.9 ppm; p=0.429). It was +and K+ content between chewers and non chewers, but the content of salivary Mg 2+, Ca2+and phosphate had significant difference.
Akut pankreatitte prokalsitonin düzeyinin mortalite üzerine etkisi
Authors: KARAKAYA Zeynep , AKYOL Pınar Yeşim , TOPAL Firdes , ESAD Fatih , AYKAÇ Mehmet Coşkun 
Published: May 2018

Amaç: Bu çalışmanın amacı başvuru ve 48. saatte alınan prokalsitonin seviyesinin mortalite ve yatış süresi üzerine etkisinin araştırılmasıdır. Gereç ve Yöntem: Kesitsel retrospektif olan çalışmamızda 3 ay içerisinde acil servise başvuran ve pankreatit tanısı ile servise yatırılan hastalar çalışmaya alındı. Çalışmaya dahil edilen tüm hastaların yaş, cinsiyet, kronik hastalık varlığı, alkol alımı, taş varlığı, ranson geliş değeri, ranson 48. saat değeri, bilgisayarlı tomografi şiddet indeksi, lökosit, platelet, lenfosit, nötrofil sayıları, nötrofil lenfosit oranları, platelet lenfosit oranları, C-Reaktif Protein, Prokalsitonin 0.saat, Prokalsitonin 48.saat düzeyleri ve bunların 6 aylık mortalite ve morbidite üzerine etkisi değerlendirildi. Bulgular: Çalışmaya alınan 39 hastanın %48.7 si (n=19)’u erkek %51.3’ü (n=20) kadındı. Pankreatit tanısı alan hastalardan %10.3 hastada (n=4) alkol kullanımı, %53.8 hastada(n=21) taş varlığı tesbit edildi. Olguların yatış süreleri ile C-Reaktif Protein değerleri arasında pozitif yönde ve istatistiksel olarak anlamlı korelasyon bulundu. 6 aylık mortalite (+) olguların Ranson 48. Saat değerleri 6 aylık mortalite (-) olguların Ranson 48. saat değerlerinden istatistiksel olarak anlamlı yüksek bulundu. Prokalsitonin başvuru esnasında, Prokalsitonin 48.saat düzeyleri ve bunların 6 aylık mortalite ve yatış süreleri üzerine istatistiksel anlamlı etkisi bulunmadı. Sonuç: Pankreatit tanılı hastalarda acil serviste C-Reaktif Protein değerlerine bakılması yatış süresinin tahmininde kullanılabilir. Prokalsitonin başvuru esnasında ve 48. saat değerleri acil serviste yatış süresi ve mortalitenin değerlendirilmesinde kullanımı uygun değildir. Ranson 48. Saat değerlendirmesi mortalite tahmininde kullanılabilir.
Çocuklarda rijit bronkoskopide anestezi: tek merkez deneyimi
Authors: HATİPOĞLU Zehra , ÖZDEN Önder , ÖZCENGİZ Dilek 
Published: May 2018

Amaç: Rijit bronkoskopi, çocuklarda başta yabancı cisim çıkarılması olmak üzere havayolunun incelenmesi ve örnek alınması için genel anestezi ile uygulanan cerrahi bir girişimdir. Retrospektif yapılan bu çalışmada rijit bronkoskopi uygulanan çocuklarda anestezi yönetimi ve perioperatif komplikasyonlar değerlendirildi.Gereç ve Yöntem: Ocak 2015 - Mart 2017 tarihleri arasında rijit bronkoskopi için alınan 74 olgu değerlendirmeye alındı. Olgulara ait bilgiler, Nükleus Medikal Bilgi Sistemi ve anestezi kayıt formlarından elde edildi. Bu kayıtlardan, hastaneye başvuru nedenleri, preoperatif özellikleri, anestezi yönetimi, komplikasyonlar ve yatış süreleri değerlendirildi.Bulgular: Olguların yaş ortancası 24 (3-156) ay, 41’i (%55.4) erkek, 33’ü (%44.6) kız olarak tespit edildi. Olgular yabancı cisim şüphesi (%40.5) ve öksürük (%31.1) şikayetleri nedeniyle hastaneye getirilmişlerdi. Olguların %52.7’sinin akciğer dinleme bulgusunda ve %67.6’sının akciğer grafisinde bir özellik olmadığı belirlendi. Anestezi indüksiyonunda intravenöz ajanlar (%91.8) ve non-depolarizan kas gevşeticilerin (%100) kullanıldığı ve manuel kontrollü ventilasyonun uygulandığı saptandı. Olguların %58.1’inden yabancı cisim çıkarıldığı belirlendi. Nöromusküler blok antagonizması için olguların %46’sında sugammadeks kullanılmıştı. Bir olguda pnömotoraks gelişirken, 5 olgu entübe olarak yoğun bakıma çıkarılmış ve mekanik ventilasyon uygulanmıştır. Sonuç: Rijit bronkoskopi, çocuklarda iyi planlanmış anestezi yöntemi ile güvenle uygulanabilir. Preoperatif değerlendirmenin iyi yapılması, intra- ve postoperatif dönemlerdeki yakın takip, olası komplikasyonların önlenmesinde etkilidir.
Evaluation of the cytotoxic and membrane damaging effects of mountain tea (Sideritis stricta Boiss & Heldr.) essential oil on parental and epirubicin-HCl resistant H1299 cells
Authors: ERDOĞAN Ayşe , ÖZKAN Aysun , ÜNAL Orhan , DÜLGEROĞLU Canan 
Published: May 2018

Purpose: In this study, we evaluated Sideritis stricta (S. stricta), as potential-oxidative agents against parental and epirubicin-HCl resistant H1299 cells. Material and Methods: Oxidative stress biomarkers such as malondialdehyde level determined in cell lysates. Assessment of cell viability was made by CellTiter-Blue® Cell Viability Assay and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay after 20-600 μg/mL essential oil concentrations treated to parental and epirubicin-HCl (drug) resistant H1299 cells for 24, 48 and 72 h. Malondialdehyde levels were assayed for determining the membrane damaging effects. Results: Parental H1299 cells were found to be more sensitive to cytotoxic effect of the essential oil. Essential oil showed cytotoxic and more selective effects depend on time and concentration. Essential oil caused increasing malondialdehyde level on both parental and drug resistant H1299 cells. The highest concentration of the essential oil (IC70) treatment caused the highest membrane damage on both parental and drug resistant H1299 cells.Conclusions: Parental and epirubicin-HCl resistant H1299 cells showed different cellular response against potential antitumour and pro-oxidative effects of essential oil.
Questões epidemiológicas e desafios no atendimento aos chamados povos isolados. Uma experiência de contato com os Korubo
Authors: Reis Roberta Aguiar Cerri , Albertoni Lucas 
Published: May 2018

Nos últimos três anos, grupos indígenas de três etnias distintas, que até então não mantinham relação permanente com o Estado ou mesmo com a sociedade envolvente, passaram a receber assistência à saúde constante e permanentemente do governo brasileiro. Dentre as políticas aplicadas a eles, destaca-se o início de intervenções biomédicas em dois grupos da etnia Korubo na Terra Indígena Vale do Javari, Amazonas. A partir da experiência dos autores, este artigo tem como objetivo relatar e refletir sobre a situação sanitária, o cuidado médico e outras ações de saúde implicados nos processos atuais de contato interétnico, em especial nos eventos ocorrido na Terra Indígena (TI) Vale do Javari envolvendo a etnia Korubo. Busca-se, assim, contribuir para uma reflexão acerca do contexto epidemiológico atual dos povos indígenas que se encontram recentemente inseridos em uma zona de contato com agentes do Estado brasileiro, bem como levantar subsídios para o planejamento de ações de saúde em uma situação de contato.
SENI SPIRITUAL DALAM KONSEPSI ESTETIKA SEYYED HOSSEIN NASR
Authors: M M. Farkhan 
Published: May 2018

This article describes a method of spiritual dimension in understanding the nature of<br />art. One of the ideas that emerged in the art world is the idea of the spiritual art<br />conceived by Seyyed Hossein Nasr. Art is a spiritual view of creativity that once a form of<br />art presupposes that actually has the dimensions or viewpoints that are not one-sided but<br />two-way, i.e. physical viewpoint or exoteric and esoteric spiritual viewpoint. <br /><br /> This study was conducted based on the hermeneutic readings to the texts of religious<br />thought. The purpose is to find an aesthetic view of the artwork that builds upon religious<br />values and how spiritual art form in the light of faith is placed in human life maqam<br />among other arts. Spiritual art is not a choice but something that exists, which should be<br />read through physical knowledge that real empirical.
Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues
Authors: Haque Ashanul , Rahman Md. Ataur , Faizi Md. Serajul Haque , Khan Muhammad S. 
Published: May 2018

Background:
Throughout the history of human civilizations, cancer has been a
major health problem. Despite the advancements made by modern medical sciences, complete
treatment or removal of cancerous cells is still a challenging task. Vinblastine, an alkaloid
obtained from Catharanthus roseus (L.) G. Don is one of the prominent antineoplastic
agents that is being clinically used. To improve the biological potential and reduce sideeffects
of this structurally complex molecule, several related analogues have been reported.
The present article reviews recently reported structurally modified vinblastine analogues and
its impact on biological activity.

Methods:
We carried out a comprehensive database search on recently reported vinblastine
analogues. Both upper (catharanthine) and lower (vindoline) structural units have been considered.
The role of functional group modification on anticancer activities has been discussed.
In addition, formulations based on vinblastine being considered by NIH, USA for
different types of cancers have also been discussed.

Results:
Around fifty papers were included in the review, including computational and experimental
ones. These papers were analysed to discuss the mechanism of action of the parent
vinblastine molecule and their analogues. The importance of each functionalities on its
anticancer activity have been discussed. This reviewed identified the potential sites of vinblastine
core where modification led to improved anticancer activity. Furthermore, several
new formulations have also been discussed which are under different phases of clinical trial.

Conclusion:
The present article highlights the importance of vinblastine in cancer chemotherapy.
Literature survey confirms that it is now possible to synthesize new molecules with
activity in picomolar range. Not only the periphery of the molecule, the core structure of this
magical molecule can be modified to achieve next generation antineoplastic agents.