bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of an Australian trial of an automated insulin delivery (AID) system and other studies support likely benefit of AID use for many Australian adults with type 1 diabetes
Authors: Jenkins Alicia J. , Januszewski Andrzej S. , Kirby Adrienne , Hendrieckx Christel , McAuley Sybil A. , Lee Melissa H. , Paldus Barbora , Vogrin Sara , de Bock Martin I. , Abraham Mary B. , Bach Leon A. , Burt Morton G. , Cohen Neale D. , Colman Peter G. , Davis Elizabeth A. , Holmes‐Walker D. J. , Kaye Joey , Keech Anthony C. , Kumareswaran Kavita , MacIsaac Richard J. , McCallum Roland W. , Sims Catriona M. , Speight Jane , Stranks Stephen N. , Sundararajan Vijaya , Trawley Steven , Ward Glenn M. , Jones Timothy W. , O'Neal David N. ,   for the Australian JDRF Closed Loop Research Group
Published: November 2024

AbstractLess than 20% of Australians with type 1 diabetes (T1D) meet recommended glucose targets. Technology use is associated with better glycaemia, with the most advanced being automated insulin delivery (AID) systems, which are now recommended as gold‐standard T1D care. Our Australian AID trial shows a wide spectrum of adults with T1D can achieve recommended targets. Other studies, including lived experience data, are supportive. Insulin pumps are not subsidised for most Australian adults with T1D. We advocate change.
A new family of solutions for graph‐restricted cooperative games: rethinking the weight of intermediary power
Authors: Alarcón Antonio C. , Gallardo José M. , Jiménez‐Losada Andrés 
Published: November 2024

AbstractIn graph‐restricted cooperative games, a group of agents, represented by the nodes of a graph, work together to make a profit. However, two agents can cooperate within a coalition only if they are connected by the graph in the coalition. Several allocation rules have been proposed for these games, but there is something in common in all of them: if a player is an indispensable intermediary to communicate with the players in a coalition, this player will receive, at least, the same share of the profit generated by the coalition as the players who belong to it. In other words, intermediation power is valued, at least, as much as active cooperation. In some situations, this is neither fair nor realistic. In this paper, we introduce a family of values for graph‐restricted games that value intermediary power less than active cooperation.
Is Exposure to Conflict‐Related Violence Associated With Less Intergroup Empathy? The Moderating Role of Ideology
Authors: Ruhrman Anat , Pliskin Ruthie , Shuman Eric , van der Toorn Jojanneke , Halperin Eran 
Published: November 2024

ABSTRACTExposure to conflict‐related violence is one of the most harmful consequences of living amidst a violent intergroup conflict. While its potential significance is profound, the impact of exposure to conflict‐related violence on intergroup empathy remains largely unexplored. The current paper aims to address this gap by proposing political ideology as a potential moderator of the exposure‐empathy link. Three studies conducted among Jewish‐Israeli participants reveal an interactive effect of exposure to conflict‐related violence and political ideology on intergroup empathy. In Study 1, high (vs. low) exposure to conflict‐related violence was associated with decreased empathy among rightists—but increased empathy among leftists—towards individual outgroup members. In Study 2, political ideology also moderated the exposure‐empathy relationship: Bereaved (vs. non‐bereaved) rightists exhibited significantly less intergroup empathy towards both an individual bereaved outgroup member and the outgroup as a whole, an effect not found among leftists. Study 3 revealed a similar, albeit marginally significant, interactive effect of exposure to conflict‐related violence and political ideology on empathy towards individuals living in a different violent conflict. Finally, an internal meta‐analysis provided further, more robust evidence for these effects. We discuss theoretical and practical implications of the findings and suggest future directions for research on this important issue.
Histone Deacetylase 7‐Derived 7‐Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration
Authors: Liu Huina , Li Hua , Bai Xuefeng , Zhao Yue , Cai Yannan , Pan Huiqing , Guo Linyan , Liu Kun , Liu Qian , Huang Xiaochun , Zampetaki Anna , Margariti Andriana , Zeng Lingfang , Cai Ting 
Published: November 2024

ABSTRACTDue to the complexity of wound healing, how to achieve successful healing is a significant clinical challenge. In this study, we found that the histone deacetylase‐7‐derived 7‐amino acid peptide (7A, MHSPGAD), especially its phosphorylated version 7Ap (MH[pSer]PGAD), increased dermal fibroblast cell HDFα proliferation and migration via elevated delta‐catenin (CTNND1) serine phosphorylation‐mediated beta‐catenin (CTNNB) nuclear translocation and subsequent upregulation of c‐Myc and cyclin D1 expression. 7Ap physically interacted with platelet‐derived growth factor receptor (PDGFR) and increased PDGFR interaction with cyclin‐dependent kinase 6 (CDK6). The PDGFR siRNA or CDK6 siRNA knockdown ablated 7AP‐induced CTNND1 phosphorylation and subsequent c‐Myc/cyclin D1 expression, indicating a novel 7Ap‐PDGFR‐CDK6‐CTNND1/CTNNB signal pathway in regulating fibroblast proliferation and migration. Furthermore, 7Ap increased human umbilic vein endothelial cell proliferation and tube formation, suggesting an angiogenic effect. In a full‐thickness excision wound rat model, the local administration of 50 ng/mL of 7Ap in hydrogel exerted a similar effect as 1 μg/mL vascular endothelial growth factor on accelerating wound healing, featured by enhanced fibroblast proliferation and migration, collagen deposition, and increased new vessel formation during the early phase of wound healing. Taken together, this study not only elicited a novel signal pathway in fibroblast proliferation but also paved an avenue to develop 7Ap as a treatment option for skin wound healing.
The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells
Authors: Jakobsen Theresa , Pløen Gro Grunnet , Behsen Alenka Djarmila , Møller Holger Jon , Plesner Torben , Dybkær Karen , Andersen Morten Nørgaard , Misund Kristine , Kristensen Lasse Sommer 
Published: November 2024

ABSTRACTMultiple myeloma (MM) is a haematological malignancy with abnormal proliferation of plasma cells in the bone marrow (BM), and MM patients with highly proliferative plasma cells have reduced overall survival. Circular RNAs (circRNAs) are endogenous, non‐coding molecules that are promising biomarkers in cancer. Here, we present the largest study of circRNAs in MM to date and explore the prognostic potential of circRNAs and the link between proliferation and circRNA expression in MM. We performed deep total RNA sequencing (RNA‐seq) on two cohorts: one cohort consisting of 45 whole BM MM patient samples and 13 healthy controls (HCs), and another cohort consisting of 43 CD138‐purified plasma cell MM patient samples. We found that circRNAs are globally upregulated in the whole BM of MM patients compared to HCs. In whole BM, low proliferation and high circRNA levels were associated with a poor prognosis, while in purified plasma cells, low proliferation and high circRNA levels were associated with a favourable prognosis. Individual circRNAs from purified plasma cells were found to be significantly associated with MM patient outcomes and provide additional prognostic value to the proliferative indexes. Together, our findings emphasise the potential of circRNAs as prognostic biomarkers in MM.
Green hydrogen production by PEM water electrolysis up to the year 2050: Prospective life cycle assessment using learning curves
Authors: Koj Jan Christian , Zapp Petra , Wieland Christoph , Görner Klaus , Kuckshinrichs Wilhelm 
Published: November 2024

AbstractWater electrolysis technologies for producing green hydrogen are promising options for avoiding the use of fossil fuels and thus limiting climate change. Hydrogen can be used in a variety of sectors, enabling sector coupling, and strengthening the security of the energy supply through its storability. Environmental impacts provoked by green hydrogen production are comparatively low and improving manufacturing processes and technological advances will enable to further reduce the demand for raw materials and electricity and thus the environmental impacts. The objective of this study is to compare the status quo with prospective trends and target values. Learning curves of expected specific electricity demand and critical raw material (CRM) intensity are applied, and environmental impacts are subsequently analyzed via life cycle assessment. This study focuses on the polymer electrolyte membrane water electrolysis technology. As a result of the calculated learning curves, the CRM intensity could be reduced by more than 96% between 2022 and 2050. The specific electricity demand is projected to be reduced by 11.2%–22.5%. Combining the extrapolated reductions of electricity and CRM demand, a climate change impact decrease of 16.5%–28.5% is possible for green hydrogen production until the year 2050.
Potential Output Pessimism and Austerity in the European Union
Authors: KUANG PEI , MITRA KAUSHIK 
Published: November 2024

AbstractThe paper develops a business cycle model with policymakers' learning about potential output to analyze the European recession following the Global Financial Crisis. The initial recession led to overpessimism about potential output and cyclically adjusted budget balance (CAB), triggering fiscal austerity. The austerity caused further recession, which reinforced potential output and CAB pessimism, requiring continued austerity. The mutual reinforcement between pessimism and austerity contributed to the prolonged recession. The model replicates new findings regarding revisions to potential output estimates and the relationship between fiscal consolidation and policymakers' beliefs. Without policymakers' overpessimism, Eurozone GDP would have been 4.5% higher in 2012.
An Evaluation of VYC‐17.5L for the Treatment of Marionette Lines: A Prospective, Open‐Label, Postmarketing Study
Authors: Cueto Sofia Ruiz Del , Urdiales Galvez Fernando , Gritti Alessandro , Kefalas Nicola , de la Guardia Carola , Kerson Graeme 
Published: November 2024

ABSTRACTBackgroundMarionette lines are a feature of the aging face, descending from the oral commissures towards the jaw. VYC‐17.5 L is a dermal filler that contains 17.5 mg/mL of hyaluronic acid (HA) and lidocaine (3 mg/mL); it is intended for the treatment of skin depressions. VYC‐17.5 L has been shown to be safe and effective in different conditions, but there is a lack of published literature on its effectiveness in marionette lines.AimsThis 12‐month prospective, open‐label, post‐marketing study evaluated the effectiveness and safety of the injectable HA filler VYC‐17.5 L for the improvement of marionette lines.MethodsAdults (≥ 18 years) with mild‐to‐severe marionette lines on the validated Allergan Marionette Line Scale (AMLS) received VYC‐17.5 L on Day 1 with optional touch‐up on Day 14. The primary endpoint was proportion of participants with ≥ 1‐point change in AMLS from baseline at Month 1 (M1). Secondary endpoints were investigator‐ and participant‐rated Global Aesthetic Improvement Scale (GAIS), FACE‐Q satisfaction with facial appearance, and appraisal of lines: marionette. Safety was assessed throughout.ResultsA total of 83 participants completed the study; 69.9% of participants had ≥ 1‐point change in AMLS at M1. Investigator and participant GAIS showed improvement. Both FACE‐Q scores significantly improved from baseline (p < 0.0001). A significant volume improvement was seen and maximized at M1. Most participant‐reported injection site reactions were mild or moderate and resolved within 8 days; 14 subjects reported adverse device effects, with the most common being pain, which resolved within 8 days.ConclusionThis prospective, open‐label study showed that VYC‐17.5 L effectively improved marionette lines and was well tolerated.
Livin’ La Vida Sola: Network Diversity and Well‐Being in Middle‐Aged Adults Living Alone
Authors: Kersten Philipp , Mund Marcus , Neyer Franz J. 
Published: November 2024

ABSTRACTBackgroundFor individuals living alone, having a diverse personal network is considered crucial for mitigating the risk of social isolation and enhancing well‐being. Although a reciprocal dynamic between network diversity and well‐being is likely, longitudinal evidence supporting reciprocal effects is limited. This study investigates dynamic transactions between network diversity and well‐being (life satisfaction, loneliness, and depressiveness) in a community‐based sample of middle‐aged adults from Germany. It also explores moderations by the duration of living alone.MethodData were drawn from the three‐wave RIKSCHA (Risks and Chances of Living Alone) project, which includes N = 389 middle‐aged adults living alone.ResultsCross‐lagged panel models revealed high rank‐order stabilities and correlated changes in network diversity and well‐being. Random‐intercept cross‐lagged panel models and dynamic panel models indicated that unobserved traits accounted for these high stabilities. Correlated changes disappeared when accounting for the trait‐like stability of variables. Across all models, no evidence of reciprocal associations between network diversity and well‐being was found. All results remained consistent regardless of the duration of living alone.ConclusionsThe study discusses trait factors accounting for the high stabilities observed in network diversity and well‐being among middle‐aged adults living alone. Future research should further explore the traits impacting successful adaptation to living alone within the context of personal networks.
Mucoadhesion and Mucins in Oral Processing: Their Role in Food Interaction, Texture, and Sensory Perception
Authors: Velopoulos Ioannis , Dimopoulou Maria , Chen Jianshe , Ritzoulis Christos 
Published: November 2024

ABSTRACTThis is a review of mucus, and its principal component, mucins, in oral processing; it examines oral processing from the viewpoint of mucins being integral functional constituents of the food after the latter's insertion into the mouth. Under this light, mucins are treated as an omni‐present functional ingredient. The chemical physics of the bolus formation is examined, focused on the role of mucins in the process. The colloidal and rheological aspects of hydrocolloids–mucin systems are subsequently examined, highlighting the role of the oral glycoproteins in complex food models and complex foods. Following the physicochemical and mechanical description of the topic, mucus is examined as a determinant of a food's sensory attributes. Its role in oral sensations such as astringency is reviewed, with a special focus on phenol–mucin interactions. The effect of mucus on the perception of saltiness is then reviewed, and the ensuing strategies for structurally‐based reduction of salt are considered. The review critically discusses the challenges and opportunities that emerge from the above, highlighting the role of mucins and their effect on food function.
A Retrospective Radiologic Analysis of the Treatment Outcomes of Ameloblastomas
Authors: Smit Chané , Robinson Liam , Fonseca Felipe P. , van Heerden Willie F. P. , Uys André 
Published: November 2024

ABSTRACTIntroductionThe current study reviewed the postoperative radiologic findings of 156 cases of ameloblastoma diagnosed at a tertiary institution in South Africa.MethodsHistologically diagnosed cases of ameloblastomas between 2012 and 2022 were retrospectively reviewed. Only cases with both pre‐ and postoperative radiographs of diagnostic quality were included in the study. The demographics, treatment and follow‐up radiologic findings, including recurrences, were assessed. This clinical data was collected from all available patient records and histopathologic reports.ResultsSeventy‐nine cases of ameloblastoma (50.97%) diagnosed at the institution had post‐treatment radiographs available and were included in the study for further analysis. Conservative treatment, including marsupialisation and/or enucleation, was performed in 11 cases (13.92%). The recurrence rate for conservatively treated cases was 44.4% after a mean follow‐up of 31.4 months. Tumour resection was performed in 72 cases (91.1%), including 4 recurrent cases previously treated conservatively. Tumour recurrence was only noted in 4 cases (7.5%) treated via surgical resection after a mean follow‐up of 25 months. Spontaneous bone regeneration was seen in 19 cases (35.8%) of ameloblastomas treated via surgical resection.ConclusionAmeloblastomas are benign neoplasms with high recurrence rates, emphasising the need for appropriate treatment and extended follow‐up periods. The high recurrence rate reported in cases of ameloblastoma managed conservatively highlighted its inappropriate use in treating conventional subtypes. The presence of bony regeneration in this study was higher than the reported literature, correlating with the overall younger age of the current sample.
Manipulation Cases in Free Will and Moral Responsibility, Part 1: Cases and Arguments
Authors: De Marco Gabriel , Cyr Taylor W. 
Published: November 2024

ABSTRACTA common style of argument in the literature on free will and moral responsibility is the Manipulation Argument. These tend to begin with a case of an agent in a deterministic universe who is manipulated, say, via brain surgery, into performing some action. Intuitively, this agent is not responsible for that action. Yet, since there is no relevant difference, with respect to whether an agent is responsible, between the manipulated agent and a typical agent in a deterministic universe, responsibility is not compatible with the truth of determinism. This paper introduces some key types of manipulation cases, the schema for a manipulation argument against compatibilism, the hard‐line/soft‐line categories of responses to manipulation arguments, and various issues that have become important in discussions of manipulation cases and arguments.
Stability of Standing Periodic Waves in the Massive Thirring Model
Authors: Cui Shikun , Pelinovsky Dmitry E. 
Published: November 2024

ABSTRACTWe analyze the spectral stability of the standing periodic waves in the massive Thirring model in laboratory coordinates. Since solutions of the linearized MTM equation are related to the squared eigenfunctions of the linear Lax system, the spectral stability of the standing periodic waves can be studied by using their Lax spectrum. We show analytically that each family of standing periodic waves is distinguished by the location of eight eigenvalues which coincide with the end points of the spectral bands of the Lax spectrum. The standing periodic waves are proven to be spectrally stable if the eight eigenvalues are located either on the imaginary axis or along the diagonals of the complex plane. By computing the Lax spectrum numerically, we show that this stability criterion is satisfied for some standing periodic waves.
Dynamics of a Memory‐Based Diffusion Model With Maturation Delay and Spatial Heterogeneity
Authors: Bu Xiaohong , Zhang Guohong , Song Yongli , Wang Xiaoli 
Published: November 2024

ABSTRACTIn this paper, we consider a single memory‐based diffusion population model with maturation delay, spatial heterogeneity, and Neumann boundary condition. When the integral of the intrinsic growth rate over the domain is nonnegative, we obtain sufficient conditions for the local stability of the positive steady state and the critical values of maturation delay for the associated Hopf bifurcation. When the integral of the intrinsic growth rate over the domain is negative, considering that the characteristic equation involves a non‐self‐adjoint operator and two delays, we utilize a geometric method to determine all bifurcation points in terms of memory and maturation delays. The impact of spatial heterogeneity on the distribution of solutions is also examined via numerical simulations. It is found that the core area of high population density is coincident with the source area of growth rate. This suggests the importance of spatial heterogeneity in shaping the distribution and dynamics of the species.
Evaluating the effectiveness and cost‐effectiveness of integrating mass drug administration for helminth control with seasonal malaria chemoprevention in Ghanaian children: Protocol for a cluster randomised controlled trial
Authors: Afolabi Muhammed O. , Adu‐Gyasi Dennis , Paintain Lucy , Tawiah Theresa , Ali Mohammed Sanni , Greenwood Brian , Asante Kwaku Poku 
Published: November 2024

AbstractObjectivesTo evaluate the effectiveness and cost‐effectiveness of integrating seasonal malaria chemoprevention (SMC) with mass drug administration for helminth control among school‐aged children living in communities where the burden of malaria and helminths is high in Ghana, West Africa.MethodsThis cluster randomised controlled trial will enrol 1200 children aged 5–10 years. Eligible children randomised to intervention clusters will receive SMC drugs (sulphadoxine‐pyrimethamine plus amodiaquine) and anthelminthic drugs for soil‐transmitted helminths—(albendazole), and for schistosomiasis (praziquantel), while children randomised to control clusters will receive SMC drugs alone. Pre‐ and post‐intervention blood, urine and stool samples will be collected from children in both clusters. The effectiveness of the concomitant delivery will be determined by checking whether the combination of SMC and anthelminthic drugs prevents anaemia in the children randomised to the intervention clusters compared to the children in the control clusters. Cost analysis and cost‐effectiveness of this integrated delivery approach will be determined by estimating the incremental costs and effects of co‐administration of SMC drugs with mass drug administration of anthelminthic drugs compared to SMC alone, including cost savings due to cases of moderate and severe anaemia averted.Expected findingsThe findings of this study will provide evidence to inform public health recommendations for an integrated control of malaria and helminths among children living in the poorest countries of the world.