bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing sustainability within territorial and urban heritage
Authors: Del Espino Hidalgo Blanca 
Published: August 2018

Purpose
The purpose of this paper is to develop a methodology to assess urban sustainability within built, urban, territorial and landscape heritage, considering that cultural heritage has recently emerged as one of the keys of urban and territorial sustainability due to its inherent properties of durability and adaptability to changes over time. The implementation pivots on a case study based on medium-sized historical cities. Both academic and official documents consider this urban category as particularly likely to demographic, environmental and economic sustainability.

Design/methodology/approach
The methodology used begins with a theoretical approach, case study delimitation and presentation of existing indicator-based systems that include heritage concerns. Then, the criteria for the selection and creation of indicators are settled to create an ad hoc system. This is tested for the case study of medium-sized historical cities in inner Andalusia, Spain.

Findings
The results obtained are merged and represented for further discussion. First, this methodology states the need of including cultural heritage aspects within sustainability assessment, especially when urban and territorial historic fabrics are involved. Second, a correlation between heritage preservation and the general level of sustainability is revealed.

Originality/value
Finally, the results provide the basis for decisions to academic, technical and administrative spheres regarding urban and territorial sustainability, especially when dealing with the incorporation of cultural heritage factors and the assessment of medium-sized cities-based case studies.
Seismic time‐lapse imaging using interferometric least‐squares migration: Case study
Authors: Sinha Mrinal , Schuster Gerard T. 
Published: August 2018

ABSTRACTSeismic time‐lapse surveys are susceptible to repeatability errors due to varying environmental conditions. To mitigate this problem, we propose the use of interferometric least‐squares migration to estimate the migration images for the baseline and monitor surveys. Here, a known reflector is used as the reference reflector for interferometric least‐squares migration, and the data are approximately redatumed to this reference reflector before imaging. This virtual redatuming mitigates the repeatability errors in the time‐lapse migration image. Results with synthetic and field data show that interferometric least‐squares migration can sometimes reduce or eliminate artifacts caused by non‐repeatability in time‐lapse surveys and provide a high‐resolution estimate of the time‐lapse change in the reservoir.
Temperature sensitivities of microbial plankton net growth rates are seasonally coherent and linked to nutrient availability
Authors: Morán Xosé Anxelu G. , Calvo‐Díaz Alejandra , Arandia‐Gorostidi Nestor , Huete‐Stauffer Tamara Megan 
Published: August 2018

SummaryRecent work suggests that temperature effects on marine heterotrophic bacteria are strongly seasonal, but few attempts have been made to concurrently assess them across trophic levels. Here, we estimated the temperature sensitivities (using activation energies, E) of autotrophic and heterotrophic microbial plankton net growth rates over an annual cycle in NE Atlantic coastal waters. Phytoplankton grew in winter and late autumn (0.41 ± 0.16 SE d−1) and decayed in the remaining months (−0.42 ± 0.10 d−1). Heterotrophic microbes shared a similar seasonality, with positive net growth for bacteria (0.14–1.48 d−1), while nanoflagellates had higher values (> 0.4 d−1) in winter and spring relative to the rest of the year (−0.46 to 0.29 d−1). Net growth rates activation energies showed similar dynamics in the three groups (−1.07 to 1.51 eV), characterized by maxima in winter, minima in summer and resumed increases in autumn. Microbial plankton E values were significantly correlated with nitrate concentrations as a proxy for nutrient availability. Nutrient‐sufficiency (i.e., > 1 μmol l−1 nitrate) resulted in significantly higher activation energies of phytoplankton and heterotrophic nanoflagellates relative to nutrient‐limited conditions. We suggest that only within spatio‐temporal windows of both moderate bottom‐up and top‐down controls will temperature have a major enhancing effect on microbial growth.
Understanding (Mis)classification Trends of Latin Americans in Fordisc 3.1: Incorporating Cranial Morphology, Microgeographic Origin, and Admixture Proportions for Interpretation
Authors: Hughes Cris E. , Dudzik Beatrix , Algee‐Hewitt Bridget F.B. , Jones Ansley , Anderson Bruce E. 
Published: August 2018

AbstractAssigning correct population affinity to a skeleton can contribute important information to an investigation—yet recent work highlights high error rates when classifying Latinos with a traditional tool, Fordisc 3.1 (FD3). Our study examines whether misclassification trends exist, and whether these can be used to infer population affinity. We examine the relationships among ancestry, geography, and FD3 misclassifications of Latinos using canonical variate analysis and unsupervised model‐based clustering of craniometrics. Northern Mexicans appear more strongly associated with FD3 references samples with elevated amounts of European ancestry (e.g., American Blacks and Whites), while Southern Mexicans are more strongly associated with FD3 reference samples with reduced amounts of European ancestry (e.g., Guatemalans and Native Americans). FD3 classifications revealed that Latinos exhibited lower posterior probabilities when compared to other common case demographics (Whites and African Americas), even when the classification was “correct.” We make recommendations for practitioner interpretation of FD3 reports for casework.
Advice and recipes for invalid and convalescent cookery in Australian cookbooks 1860–1950
Authors: Williams Peter 
Published: August 2018

AimsThe aims of the present study were to assess the prevalence of recipes about invalid cookery in Australian cookbooks published from 1860 to 1950; describe the dishes regarded as suitable for invalids and summarise the advice about how best to feed invalids or convalescents in the home.MethodsUsing published bibliographies, the Trove database, and the author's private collection, all available cookbooks published in Australia up to 1950 were reviewed and all recipes and advice about feeding invalids were recorded.ResultsEight hundred and eighty‐nine book titles were examined and 25% contained some recipes specifically designed for people who were sick or convalescing. One thousand, four hundred and seventy‐one different recipes were recorded with more than half for beverages, desserts and soups. The most common recipes were for beef tea, barley water, gruel and meat broths. Advice about feeding focused on the food requirements of invalids, safe and appealing meal service, cooking methods and suitable food choices. The recipes and advice did not appear to change substantially over the nine decades and most did not appear to be based on any clear scientific evidence.ConclusionsMany of the general principles of invalid cookery in these books are similar to the requirements of the light diet, commonly used in Australian hospitals up until the 1980s. Further research into the source and rationale for the advice in these books would be worthwhile.
Safety of endobronchial ultrasound‐guided transbronchial needle aspiration in patients with lung cancer within a year after percutaneous coronary intervention
Authors: Gil Hyun‐Il , Choe Junsu , Jeong Byeong‐Ho , Um Sang‐Won , Jeon Kyeongman , Hahn Joo‐Yong , Kim Hojoong , Kwon O Jung , Chang Yoon Soo , Lee Kyungjong 
Published: August 2018

BackgroundEndobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) may be necessary for patients with incidental lung cancer during or after coronary intervention. Although EBUS‐TBNA is quite safe, the safety in patients who recently received percutaneous coronary intervention (PCI) has not been demonstrated. The aim of this study was to assess the safety of EBUS‐TBNA in patients with lung cancer who underwent PCI within one year.MethodsWe retrospectively reviewed the medical records of 24 patients who underwent EBUS‐TBNA within one year after PCI between May 2009 and June 2017. Cardiovascular complications (death, myocardial infarction, arrhythmia, and acute heart failure) were assessed as primary outcomes. Procedural‐related complications were assessed as secondary outcomes.ResultsThe coronary artery diseases requiring PCI were: myocardial infarction (n = 10), unstable angina (n = 10), stable angina (n = 2), and silent ischemia (n = 2). The median interval between PCI and EBUS‐TBNA was 125 days (interquartile range: 66–180). Atrial fibrillation with a rapid ventricular response temporarily occurred in one patient after EBUS‐TBNA. No other significant cardiovascular complications were encountered. Fifteen patients were administered an anti‐thrombotic agent the day of EBUS‐TBNA, while four had ceased taking the agent < 4 days before EBUS‐TBNA, however, there was no significant bleeding among those patients.ConclusionEBUS‐TBNA was safe and did not cause serious adverse events in patients with lung cancer who required tissue confirmation or mediastinal staging within one year after PCI. Incidental lung cancer found during or after a coronary intervention should be actively evaluated by EBUS‐TBNA.
Expression and regulation of metallothioneins in myometrium and fetal membranes
Authors: Lappas Martha 
Published: August 2018

ProblemMetallothioneins (MTs) play important roles in regulating oxidative stress, inflammation, and hormone signaling. These processes play a major role in labor at term and preterm. The aims of this study were to characterize (a) temporal‐ and labor‐associated changes and (b) the effect of pro‐inflammatory and pro‐labor insults on the expression of MT1 isoforms, MT2A, MT3, and MT4 in fetal membranes and myometrium.Method of StudyThe expression of MTs was assessed in fetal membranes and myometrium from nonlaboring and laboring women at preterm and term by RT‐qPCR. Tissue explants were used to assess the effect of pro‐inflammatory cytokines and Toll‐like receptor (TLR) ligands on the expression of MTs in fetal membranes and myometrium.ResultsIn fetal membranes, the expression of MT1A, MT1E, MT1F, MT1X, and MT2A was higher at term compared with preterm. Preterm labor and preterm histological chorioamnionitis were associated with increased expression of MT1A, MT1G, MT1M, MT1X, MT2A, and MT3. Term labor was associated with increased expression of MT1A, MT1F, MT1X, MT2A, and MT3 in fetal membranes and expression of MT1A, MT1E, MT1F, MT1G, MT1M, MT1X, MT2A, and MT3 in myometrium. Pro‐inflammatory cytokines and TLR ligands increased the expression of MT1A, MT1E, MT1F, MT1G, MT1H, MT1X, and MT2A in fetal membranes and myometrium.ConclusionTemporal‐, labor‐, and infection‐associated increases in MT1 isoforms, MT2A, and MT3 have been observed in fetal membranes and/or myometrium. Furthermore, pro‐inflammatory cytokines and bacterial and viral products increased the expression of MT1 isoforms, MT2A, MT3, and MT4 mRNA expression in fetal membranes and myometrium.
Men's expectations and experiences of fertility awareness assessment and counseling
Authors: Sylvest Randi , Koert Emily , Vittrup Ida , Birch Petersen Kathrine , Hvidman Helene W , Hald Finn , Schmidt Lone 
Published: August 2018

AbstractIntroductionMen play an important role in couples' decisions about the timing of parenthood and they tend to delay parenthood. The reasons for delaying childbearing are multifaceted and complex. Their decisions may be based on a lack of accurate information about the reproductive life span and the consequences of delaying parenthood. The aim of this study was to explore men's expectations and experiences of fertility counseling.Material and methodsData were collected through semi‐structured qualitative interviews with 21 men attending either the Fertility Assessment and Counseling Clinic in Copenhagen or in Horsens, Denmark. The men had no known fertility problems before going to the fertility counseling. They were interviewed before and after fertility counseling.ResultsThe men were not concerned about their fertility before going to counseling. They believed they would be able to conceive whenever they wanted. Three of them had low semen quality and felt “punched in the gut” when they received these results at the fertility counseling. The study participants preferred clear and concrete information, and relevant knowledge at the right time was very important. The men felt empowered after the fertility counseling because they were equipped with concrete information that could inform their parenthood plans and decisions. Even the men who received unexpected bad news felt positive about the counseling. The participants perceived their knowledge and awareness of risk factors concerning fertility had increased.ConclusionsMen may benefit from an individualized approach where their fertility is assessed and they receive tailored fertility counseling specific to their personal fertility results. This type of intervention may be effective in increasing men's fertility awareness because it is personally relevant.
Impact of Heart Rate on Pulsatile Hemodynamic Performance in a Neonatal ECG‐Synchronized ECLS System
Authors: Wang Shigang , Moroi Morgan K. , Force Madison , Kunselman Allen R. , Ündar Akif 
Published: August 2018

AbstractThe experimental circuit consisted of an i‐cor diagonal pump, a Medos Hilite 800 LT oxygenator, an 8Fr Biomedicus arterial cannula, a 10Fr Biomedicus venous cannula, and six feet of 1/4 in ID tubing for arterial and venous lines. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 40%). Trials were conducted at various heart rates (90, 120, and 150 bpm) and flow rates (200, 400, and 600mL/min) under nonpulsatile and pulsatile mode with pulsatile amplitudes of 1000–4000rpm (1000 rpm increments). Real‐time pressure and flow data were recorded for analysis. The i‐cor pump was capable of creating nonpulsatile and electrocardiography (ECG)‐synchronized pulsatile flow, and automatically reducing pulsatile frequency by increasing the assist ratio at higher heart rates. Reduced pulsatile frequency led to lower hemodynamic energy generation but did not affect circuit pressure drop. Pulsatile flow delivered more hemodynamic energy to the pseudopatient when compared with nonpulsatile flow. The pump generated more hemodynamic energy with higher pulsatile amplitudes. The i‐cor pump can automatically adjust the pulsatile assist ratio to create pulsatile flow at higher heart rates, although this caused some hemodynamic energy loss. Compared with nonpulsatile flow, pulsatile flow generated and transferred more hemodynamic energy to the neonate during ECLS (200–600mL/min), especially at high pulsatile amplitudes and low flow rates.
Blood Purification With CytoSorb in Critically Ill Patients: Single‐Center Preliminary Experience
Authors: Calabrò Maria Grazia , Febres Daniela , Recca Gaia , Lembo Rosalba , Fominskiy Evgeny , Scandroglio Anna Mara , Zangrillo Alberto , Pappalardo Federico 
Published: August 2018

AbstractThe CytoSorb adsorber, a blood purification therapy, is able to remove molecules in the 5–60 kDa range which comprises the majority of inflammatory mediators and some endogenous molecules. We aimed to evaluate CytoSorb therapy on clinical outcomes in critically ill patients. A retrospective case series study, from February 2016 to May 2017, was performed in 40 patients with multiple organ failure who received CytoSorb treatment. There were 28 patients with cardiogenic shock, 2 with septic shock, 9 with acute respiratory distress syndrome, and 1 with liver failure. Nineteen patients (47%) underwent extracorporeal membrane oxygenation, 11 (27%) had an intra‐aortic balloon pump, 9 (22%) were implanted with Impella, 6 (15%) had a ventricular assist device, and 18 (45%) were treated with continuous veno‐venous hemofiltration. After CytoSorb treatment, total bilirubin decreased from 11.6 ± 9.2 to 6.8 ± 5.1 mg/dL (P = 0.005), lactate from 12.1 ± 8.7 to 2.9 ± 2.5 mmol/L (P < 0.001), CPK from 2416 (670–8615) to 281 (44–2769) U/L (P < 0.001) and LDH from 1230 (860–3157) to 787 (536–1148) U/L (P < 0.001). The vasoactive‐inotropic score after 48 h of treatment was reduced to 10 points, P = 0.009. Thirty‐day mortality was 55% and ICU mortality was 52.5% at expected ICU mortality of 80%. Our study shows that CytoSorbTM treatment is effective in reducing bilirubin, lactate, CPK and LDH, in critically ill patients mainly due to cardiogenic shock. There is a need for randomized controlled trials to conclude on the potential benefits blood purification with CytoSorb in critically ill patients.
LVAD Pump Flow Does Not Adequately Increase With Exercise
Authors: Gross Christoph , Marko Christiane , Mikl Johann , Altenberger Johann , Schlöglhofer Thomas , Schima Heinrich , Zimpfer Daniel , Moscato Francesco 
Published: August 2018

AbstractLeft ventricular assist devices (LVADs) restore cardiovascular circulatory demand at rest with a spontaneous increase in pump flow to exercise. The relevant contribution of cardiac output provided by the LVAD and ejected through the aortic valve for exercises of different intensities has been barely investigated in patients. The hypothesis of this study was that different responses in continuous recorded pump parameters occur for maximal and submaximal intensity exercises and that the pump flow change has an impact on the oxygen uptake at peak exercise (pVO2). Cardiac and pump parameters such as LVAD flow rate (QLVAD), heart rate (HR), and aortic valve (AV) opening were analyzed from continuously recorded LVAD data during physical exercises of maximal (bicycle ergometer test) and submaximal intensities (6‐min walk test and regular trainings). During all exercise sessions, the LVAD speed was kept constant. Cardiac and pump parameter responses of 16 patients for maximal and submaximal intensity exercises were similar for QLVAD: +0.89 ± 0.52 versus +0.59 ± 0.38 L/min (P = 0.07) and different for HR: +20.4 ± 15.4 versus +7.7 ± 5.8 bpm (P < 0.0001) and AV‐opening with 71% versus 23% of patients (P < 0.0001). Multi‐regression analysis with pVO2 (R2 = 0.77) showed relation to workload normalized by bodyweight (P = 0.0002), HR response (P = 0.001), AV‐opening (P = 0.02), and age (P = 0.06) whereas the change in QLVAD was irrelevant. Constant speed LVADs provide inadequate support for maximum intensity exercises. AV‐opening and improvements in HR show an important role for higher exercise capacities and reflect exercise intensities. Changes in pump flow do not impact pVO2 and are independent of AV‐opening and response in HR. An LVAD speed control may lead to adequate left ventricular support during strenuous physical activities.
BUILDING THE MANAGERIAL CAPITAL OF AGRICULTURAL COOPERATIVES IN AFRICA
Authors: FRANCESCONI Gian Nicola , WOUTERSE Fleur 
Published: August 2018

ABSTRACTAgricultural cooperatives in Africa tend to be community‐based organizations defined by principles of inclusion, voluntarism, democracy, equity, autonomy, mutuality and solidarity. This means that they generally operate in accordance with the principles endorsed by the International Cooperative Alliance (ICA). However, only a few of these organizations are successful in commercializing the agricultural produce of their members. In this study, we argue that growth‐problems leading to commercial failure and organizational degeneration in these cooperatives can be attributed to a lack of managerial capital. Drawing on the literature and evidence from the field we set out key management solutions for counterbalancing cooperative principles in the context of rural Africa. These solutions were taught to the leaders and managers of 362 cooperatives at four training events held in Madagascar, Malawi and twice in Uganda. Using a production function for cognitive achievement and key informant interviews, we find that our training contributed to the adoption of the proposed solutions by some of the cooperatives. Using the Ugandan sub‐ sample, we estimate an OLS regression and a PSM model to show that the training translated into higher revenues per member generated through collective commercialization.
Survival of Campylobacter jejuni and Campylobacter coli water isolates in lake and well water
Authors: Nilsson Anna , Johansson Cecilia , Skarp Astrid , Kaden René , Bertilsson Stefan , Rautelin Hilpi 
Published: August 2018

The role of water for transmission of Campylobacter jejuni and C. coli to humans might be underestimated, as factors important for bacterial viability in water are largely unknown. We have studied water survival of seven C. jejuni and eight C. coli isolates originally isolated from Swedish waters, together with selected reference strains, over eight days at 4 °C in the dark in untreated water collected from a local lake and a private well. To study seasonality, lake water samples were collected during spring and autumn. Samples for culturable bacterial counts were taken on days 2, 4, 6, and 8 and compared to the start inoculum. For C. jejuni, a significantly better survival was observed in autumn than in spring lake water. Furthermore, C. jejuni had a significantly better survival than C. coli in autumn lake and well water samples; the rate of culturability loss was almost double for C. coli in autumn lake water. These findings contribute to a better understanding on the seasonality of waterborne Campylobacter infections and the general predominance of C. jejuni.
Increased levels of serum miR‐148a‐3p are associated with prostate cancer
Authors: Dybos Sandra Amalie , Flatberg Arnar , Halgunset Jostein , Viset Trond , Rolfseng Toril , Kvam Solveig , Skogseth Haakon 
Published: August 2018

Prostate cancer (PCa) is one of the most common types of cancer and the fifth leading cause of death among men worldwide. The tools for diagnosing PCa have limited value, and to improve correct diagnosis there is a need for markers that can contribute to a more precise diagnosis, which would lead to proper treatment of only those patients who need it. Micro RNA (miRNA) plays a key role in the development of cancer and is therefore a potential marker for PCa. Next‐generation sequencing was used to discover differences in miRNA expression between serum samples from PCa patients and healthy controls, and the results were validated by quantitative real‐time polymerase chain reaction. Detection of the miRNA of interest was attempted in prostate tissue by in situ hybridization. All samples were collected in collaboration with Biobank1®. By miRNA sequencing of serum samples, significant expression of some miRNAs in patients with PCa and healthy controls was detected. This study showed that miR‐148a‐3p is upregulated in men with PCa, and the miRNA is differentially expressed in PCa patients compared to healthy controls. The results also showed that miR‐148a‐3p is located in prostate tissue.