bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community Care Management: Advanced Practice Nurses as Care Managers
Authors: Waszynski Christine M. , Murakami Wendy , Lewis Mary 
Published: September 2018

A group of advanced practice nurses partnered with a major insurer in the design and implementation of a care coordination model for high-risk older adults. This article will discuss the process of such an undertaking, highlighting the successes and barriers encountered. The key elements of this program included early identification and regular reassessment of each member’s acuity level; fostering close partnerships between individual or teams of APRNs and groups of physicians; and uninterrupted clinical management of high-risk members across the health care continuum. This model was designed to achieve the following outcomes: to support the physician management of high-risk, chronic individuals; to increase or maintain the health of members; and to reduce health care costs. Outcome studies have demonstrated a substantial net savings by decreasing acute care admissions by 54%, reducing hospital days by 42%, and trimming primary care physicians’ and specialists’ visit costs by 37%. There was a 33% reduction in the overall costs of health care for members enrolled in this program. Physicians and members both rated their satisfaction with the APRN-based model of care as very high.
Penelusuran Miskonsepsi Operasi Bilangan Bulat dalam Pembelajaran Matematika Pada Mahasiswa PGMI dengan Menggunakan Cri (Certainty of Respon Index)
Authors: Fatmahanik Ulum 
Published: September 2018

Abstract: The academic anxiety in this paper is the misconception of MI prospective teachers at IAIN Ponorogo in understanding the concept of integer operations. This study aims to trace the misconception of integer operations which includes addition, subtraction, multiplication and division by using a number line. The research method used is descriptive qualitative. The subjects of this study are students of GMI.D class of PGMI IAIN Ponorogo who are taking the course of mathematics learning MI which amounted to 32 students. To trace the misconception of students used Certainty of Response Index (CRI) so as to distinguish between students who have misconception with students who do not understand the concept. The instrument used in this study is a test in the form of a diagnostic test in the form of essays accompanied by Certainty of Response Index (CRI), and interviews conducted on students who experience misconception. Based on the results of the search for misconceptions of integer operations the causes of such misconceptions are 1) the principle of using the number lines in inconsistent integer operations; 2) count operation and type of number; 3) the interpretation of the form a + (-b); a - (-b); a x b and a: b, 4) the number of irrelevant reference books; 5) wrong concept of integer operation. ملخص: المشكلة الدافعة لإجراء هذه الدراسة هي المفاهيم الخاطئة لدى طلاب قسم التربية لإعداد مدرسي المدارس الابتدائية الجامعة الإسلامية الحكومية فونوروغو في فهم مفهوم عملية عدد صحيح. هدف هذا البحث إلى العثور على المفاهيم الخاطئة عن عملية عدد صحيح المحتوية على الجمع، والطرح، والتقسيم باستخدام الخط العددي. استخدم هذا البحث طريقة البحث الوصفي الكيفي. وموضوعات البحث هي طلاب الصف GMI.D قسم إعداد معلمي المدارس الإبتدائية الجامعة الإسلامية الحكومية فونوروغو وهم يدرسون تعليم الرياضيات للمدارس الإبتدائية، وعددهم 32 طالبا. وللعثور على المفاهيم الخاطئة لدى الطلاب استخدمت أداة Certainty of Response Index (CRI) حتى يمكن التفريق بين الطلاب المصابون بالمفاهيم الخاطئة والطلاب غير الفاهمين للمفاهيم. وأداة البحث المستخدمة هي الاختبار التشخيصي وفيه الأسئلة الاستيعابية ومعها Certainty of Response Index (CRI)، والمقابلة التي تجرى على الطلاب المصابين بالمفاهيم الخاطئة. ونتائج البحث دلت على أن أسباب وقوع المفاهيم الخاطئة لدى الطلاب هي : 1) أساس استخدام الخط العددي في عملية عدد صحيح الغير المنضبط، 2) عملية الحساب وأنواع العدد، 3) تفسير الشكل a + (-b); a – (-b); a x b dan a : b, ، 4) كثرة المراجع غير المناسبة، 5) المفهوم الخاطئ عن عملية العدد الصحيح.
Improving an Active‐Optical Reflectance Sensor Algorithm Using Soil and Weather Information
Authors: Bean G.M. , Kitchen N.R. , Camberato J.J. , Ferguson R.B. , Fernandez F.G. , Franzen D.W. , Laboski C.A.M. , Nafziger E.D. , Sawyer J.E. , Scharf P.C. , Schepers J. , Shanahan J.S. 
Published: September 2018

Core Ideas
Canopy sensor performance improved using site‐specific information.
Evenness of early‐season rainfall is crucial for adjusting N recommendations.
Adjusting N recommendations using measured vs. USDA mapped soil data performed alike
Active‐optical reflectance sensors (AORS) use light reflectance characteristics from a crop canopy as an indicator of the plant’s N health. However, studies have shown AORS algorithms used in conjunction with measured reflectance characteristics for corn (Zea mays L.) N fertilizer rate recommendations are not consistently accurate. Our objective was to determine if soil and weather information could be utilized with an AORS algorithm developed at the University of Missouri (ALGMU) to improve in‐season (∼V9 corn development stage) N fertilizer recommendations. Nitrogen response trials were conducted across eight states over three growing seasons, totaling 49 sites with soils ranging in productivity. Nitrogen fertilizer rates according to the ALGMU were compared to economic optimal nitrogen rate (EONR). Without soil and weather information included, the root mean square error (RMSE) of the difference between ALGMU and EONR (MUDIFF) was 81 and 74 kg N ha−1 for treatments receiving 0 and 45 kg N ha−1 applied at planting, respectively. When ALGMU was adjusted using weather (seasonal precipitation and distribution prior to sidedress) and soil clay content, the RMSE was reduced by 24 to 26 kg N ha−1. Without adjustment, 20 and 29% of sites were within 34 kg N ha−1 of EONR with 0 and 45 kg N ha−1 at planting, respectively. But with adjustment for soil and weather data, 45 and 51% of sites were within 34 kg N ha−1 of EONR. These results show that weather and soil information could be used to improve ALGMU N recommendation performance.
The Effect of Drying around Power Cables on the Vadose Zone Temperature
Authors: Hruška Marina , Clauser Christoph , De Doncker Rik W. 
Published: September 2018

Core Ideas
We show the impact of soil hydraulic properties on its critical temperature.
Ambient conditions have a larger impact in some fields than local soil parameters.
We introduce a parameter for optimizing cable backfill based on hydraulic properties.
The effects of moisture migration away from power cables depend strongly in most soils on whether the soil has reached the so‐called critical conditions (e.g., critical temperature) for a dry‐out. However, research on how to estimate this critical temperature has been limited. We solved numerically a differential equation for the planar case of steady‐state coupled heat and mass transfer in porous media, using the van Genuchten–Mualem model for the hydraulic properties of the medium. The critical isotherm is assessed by the temperature at which the steepest change occurs in the moisture content with temperature. We considered the impact of the properties of the surrounding medium and of the ambient temperature and moisture content on the dry‐out temperature. We found that seasonal variations in ambient conditions in a field in Italy have a greater impact on the critical temperature than the variations in soil properties in that field (under the assumption of a nearly uniform moisture content with depth). However, our analysis shows that, under certain conditions, a change in the van Genuchten parameter n and in a specific combination of parameters that we call a dynamic parameter can have as large an effect on the critical temperature. This suggests a direction in the optimization of backfill materials.
Electrocardiographic Assessment and Genetic Analysis in Neonates: a Current Topic of Discussion
Authors: Sarquella-Brugada Georgia , Cesar Sergi , Zambrano Maria Dolores , Fernandez-Falgueras Anna , Fiol Victoria , Iglesias Anna , Torres Francesc , Garcia-Algar Oscar , Arbelo Elena , Brugada Josep , Brugada Ramon , Campuzano Oscar 
Published: September 2018

Background:Sudden death of a newborn is a rare entity, which may be caused by genetic cardiac arrhythmias. Among these diseases, Long QT syndrome is the most prevalent arrhythmia in neonates, but other diseases such as Brugada syndrome, Short QT syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia also cause sudden death in infants. All these entities are characterized by well-known alterations in the electrocardiogram and the first symptom of the disease may be an unexpected death. Despite the low prevalence of these diseases, the performance of an electrocardiogram in the first hours or days after birth could help identify these electrical disruptions and adopt preventive measures. In recent years, there has been an important impulse by some experts in the scientific community towards the initiation of a newborn electrocardiogram-screening program, for the detection of these electrocardiographic abnormalities. In addition, the use of genetic analysis in neonates could identify the cause of these heart alterations. Identification of relatives carrying the genetic alteration associated with the disease allows adoption of measures to prevent lethal episodes.Conclusion:Recent technological advances enable a comprehensive genetic screening of a large number of genes in a cost-effective way. However, the interpretation of genetic data and its translation into clinical practice are the main challenges for cardiologists and geneticists. However, there is important controversy as to the clinical value, and cost-effectiveness of the use of electrocardiogram as well as of genetic testing to detect these cases. Our review focuses on these current matters of argue.
In Vitro Release Test of Nano-drug Delivery Systems Based on Analytical and Technological Perspectives
Authors: Nemutlu Emirhan , Eroğlu İpek , Eroğlu Hakan , Kır Sedef 
Published: September 2018

Background:Nanotech products are gaining more attention depending on their advantages for improving drug solubility, maintenance of drug targeting, and attenuation of drug toxicity. In vitro release test is the critical physical parameter to determine the pharmaceutical quality of the product, to monitor formulation design and batch-to-batch variation.Methods:Spectrophotometric and chromatographic methods are mostly used in quantification studies from in vitro release test of nano-drug delivery systems. These techniques have advantages and disadvantages with respect to each other considering dynamic range, selectivity, automation, compatibility with in vitro release media and cost per sample.Results:It is very important to determine the correct kinetic profile of active pharmaceutical substances. At this point, the analytical method used for in vitro release tests has become a very critical parameter to correctly assess the profiles. In this review, we provided an overview of analytical methods applied to the in vitro release assay of various nanopharmaceuticals.Conclusion:This review presents practical direction on analytical method selection for in vitro release test on nanopharmaceuticals. Moreover, precautions on analytical method selection, optimization and validation were discussed.
Development and Validation of an RP-HPLC Method for Determination of Atorvastatin and its Hydroxyl Metabolites in Human Plasma
Authors: Sowińska Dagmara , Pogorzelska Alicja , Rakicka Marlena , Sznura Justyna , Janowska Justyna , Gorzycka Patrycja , Malak Mateusz , Karażniewicz-Łada Marta 
Published: September 2018

Background:
Atorvastatin (AT) belongs to cholesterol-lowering agents, commonly used in
patients with an increased risk of cardiovascular disease. The drug, as well as its hydroxyl metabolites,
exhibit pharmacological activity, and their plasma levels may be helpful in the assessment of the therapeutic
effectiveness.

Objective:
Development and validation of a fast and reproducible RP-HPLC method with UV detection
for the simultaneous determination of atorvastatin and its active metabolites, para-hydroxy-atorvastatin
(p-OH-AT) and ortho-hydroxy-atorvastatin (o-OH-AT) in human plasma.

Methods:
Optimal conditions of chromatographic separation of the analytes, as well as rosuvastatin,
chosen as an internal standard, were studied. The absorbance of the compounds was measured at λ=248
nm. Validation of the method was performed. The usefulness of the method was confirmed for determination
of the analytes in plasma of patients treated with the drug.

Results:
Total peak separation was achieved at LiChrospher 100 RP-18 column with a mobile phase
composed of methanol and water (1:1,v:v) and a flow rate of 1.2 ml/min. The method was linear in the
ranges of 0.025 - 1.0 μg/ml for AT, o-OH-AT and p-OH-AT. Intra- and inter-assay precision expressed
as relative standard deviation was ≤13% for AT, ≤12% for p-OH-AT and ≤11% for o-OH-AT. Intraand
inter-day accuracy of the method, expressed as a relative error, was ≤15%.

Conclusion:
The elaborated HPLC method is specific, repeatable, reproducible, adequately accurate
and precise and fulfills the validation requirements for the bioanalytical method. The method was
successfully applied for analysis of atorvastatin and its o-hydroxy metabolite in plasma of patients
treated with the drug.
S-Phase Kinase-Associated Protein-2 and Nuclear Factor-kappa Beta as Molecular Targets of Oral Burkitt’s Lymphoma Cell Induced by Quinolinone Derivate-Vesnarinone
Authors: Supriatno  
Published: September 2018

Background:
3,4-Dihydro-6-[4-3,4-dimethoxybenzoyl-1-piperazinyl]-2(1H)-quinolinone
(vesnarinone), a novel inotropic drug with unique and complex mechanisms of action, is
known to show antitumor activity against several human malignancies. In the present study,
vesnarinone-induced signal transduction of S-phase kinase-associated protein 2 (Skp2) and
Nuclear Factor-kappa Beta (NF-κB) as molecular targets of oral malignant Burkitt’s lymphoma
(Raji cells) was evaluated.

Materials and Methods:
Raji cells were incubated with vesnarinone at concentrations of 0,
1.25x10-2, 2.50x10-2, or 5.0x10-2 Molar. After 24 h, chemotactic cell migration was examined by
a Boyden chamber kit. Apoptosis induction was observed by caspase-9 colorimetric assay. To
evaluate levels of Skp2, NF-kB, and α-tubulin, Western blot analysis was performed.

Results:
Vesnarinone markedly suppressed chemotactic cell migration and significantly induced
apoptosis by increasing the caspase-9 activity of Raji cells through down regulation of Skp2
and NF-κB.

Conclusion:
Vesnarinone decreased the expression of Skp2 and NF-κB indicating these molecules
may be targeted for the treatment of oral malignant Burkitt’s lymphoma (BL). The results
of this work offer a promising therapeutic approach for BL tumors.
Performance of Cone Beam Computed Tomography Systems in Visualizing the Cortical Plate in 3D Image Reconstruction: An In Vitro Study
Authors: Shokri Abbas , Jamalpour Mohammad Reza , Eskandarloo Amir , Godiny Mostafa , Amini Payam , Khavid Atefeh 
Published: September 2018

Introduction:
Cortical bone is an important anatomical structure and its thickness needs to be determined prior to many dental procedures to ensure treatment success. Imaging modalities are necessarily used in dentistry for treatment planning and dental procedures. Three-dimensional image reconstruction not only provides visual information but also enables accurate measurement of anatomical structures; thus, it is necessarily required for maxillofacial examination and in case of skeletal problems in this region.

Aims:
This study aimed to assess the ability of three Cone Beam Computed Tomography (CBCT) systems including Cranex 3D, NewTom 3G and 3D Promax for Three-Dimensional (3D) image reconstruction of the cortical plate with variable thicknesses.

Methods:
Depending on the cortical bone thickness, samples were evaluated in three groups of ≤ 0. 5 mm, 0.6 -1 mm and 1.1-1.5 mm cortical bone thickness. The CBCT scans were obtained from each sample using three systems, their respective FOVs, and 3D scans were reconstructed using their software programs. Two observers viewed the images twice with a two-week interval. The ability of each system in the 3D reconstruction of different thicknesses of cortical bone was determined based on its visualization on the scans. The data were analyzed using SPSS and Kappa test.

Results:
The three systems showed the greatest difference in the 3D reconstruction of cortical bone with < 0.5 mm thickness. Cranex 3D with 4×6 cm2 FOV had the highest and 3D Promax with 8×8 cm2 FOV had the lowest efficacy for 3D reconstruction of cortical bone. Cranex 3D with 4×6 cm2 and 6×8 cm2 FOVs and NewTom 3G with 5×5 cm2 and 8×5 cm2 FOVs showed significantly higher efficacy for 3D reconstruction of cortical bone with 0.6-1mm thickness while 3D Promax followed by NewTom 3G with 8×8 cm2 FOV had the lowest efficacy for this purpose.

Conclusion:
Most CBCT systems have high efficacy for 3D image reconstruction of cortical bone with thicknesses over 1 mm while they have poor efficacy for image reconstruction of cortical bone with less than 0.5 mm thickness. Thus, for accurate visualization of anatomical structures on CBCT scans, systems with smaller FOVs and consequently smaller voxel size are preferred.
Non-Antimicrobial Drugs: Etodolac as a Possible Antimicrobial or Adjuvant Agent Against ESKAPE Pathogens
Authors: Pereira Sónia G. , Domingues Vanessa S. , Theriága João , Chasqueira Maria de Jesus , Paixão Paulo 
Published: September 2018

Introduction:Multiple-drug resistant bacteria are emerging exponentially in healthcare units, threatening public health and requiring novel therapeutic approaches. In 2017, World Health Organization published a list that frames antimicrobial resistant bacteria into priority levels for research of novel drugs to fight them.Methods & Materials:Antimicrobial resistant ESKAPE (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,Enterobactersp.) andEnterococcus faecalisandEscherichia colipathogens are present in this list. Representative isolates of each species were used to test the Antibacterial and anti-biofilm formation activities of Etodolac (a Non-Steroidal Anti-Inflammatory Drug, NSAID) at 10 and 1 mM using a broth microdilution technique.Results & Discussion:Statistically significant (p< 0,05) results were observed against all tested gram-positives, particularly anti-biofilm activity againstE. faecium. Etodolac had an almost null influence on tested gram-negatives, with the exception of oneA. baumanniiclinical isolate regarding biofilm formation inhibition. Observed differences deserve further analysis and prospection of the involved mechanisms, to unravel possible novel bacterial targets for drug development. Similar work with other NSAID’s may also be worth exploring to ascertain novel therapeutic applications for these drugs, particularly regarding biofilm formation inhibition,per sior as adjuvants of current antibiotherapy, mainly against gram-positives, as suggested by present work.Conclusion:Already approved drugs in terms of pharmacokinetics and safety may deploy faster solutions for antimicrobial therapy against priority pathogens. Current work intends to bring attention to that possibility, particularly regarding NSAIDs, anti-biofilm formation and top priority pathogens.
Maternal Risk Factors Associated with Low Birth Weight in Indonesia
Authors: Siramaneerat Issara , Agushybana Farid , Meebunmak Yaowaluck 
Published: September 2018

Background:
Low birth weight (LBW) is a major risk factor for death and disease in the fetus and newborn infant. However, the study about LBW and maternal risk factors involved in Indonesia is still limited.

Objective:
The present study attempted to examine the association of maternal risk factors including mother’s age, mother and husband education, mother and husband occupation and wealth, ANC visit, desired pregnancy and obstetric complication toward the occurrence of low birth weight infant across region and family wealthy.

Methods:
This study employed the data from the national survey of Indonesia Demographic and Health Survey (IDHS). The latest births from married women who gave birth within 2 years (2011 and 2012) preceding the IDHS were considered as sample selection. It was approximately 15,126 respondents. The predicted risks of low birth weight were estimated using multilevel logistic analysis.

Results:
Data were collected on 15,126 pregnant women who reported 10.2% were with LBW infants. When using the multilevel logistic analysis, the factors associated with LBW were maternal delivery-baby age, mother’s education, antenatal care and pregnancy complication at significant levels of 0.01.

Conclusion:
The prevalence of preterm infants in this study was quite high. Factors affecting LBW were maternal age, maternal education, ANC visits and pregnancy complication. The ANC visit of pregnant women is a potential and feasible activity to reduce the incidence of LBW.
Stigmatising Attitudes Towards Depression and Alcohol Misuse in Young People: Relationships with Help-Seeking Intentions and Behavior
Authors: Cheetham Ali , Jorm Anthony F. , Wilson Coralie , Berridge Bonita J. , Blee Fiona , Lubman Dan I. 
Published: September 2018

Background and Objective:Adolescents experiencing mental health problems often approach their peers rather than seeking professional help. A better understanding of adolescents’ stigmatising attitudes towards mental illness will help inform interventions that aim to improve the quality of advice that young people provide to their peers. In particular, there is a need for research examining adolescents’ attitudes towards alcohol misuse, given it’s increase in prevalence during this period as well as the adverse outcomes that are associated with untreated early drinking problems.Methods:High-school students (n=2447) were recruited as part of an intervention focussed on overcoming barriers to accessing help for mental health and substance use problems. Participants were presented with two vignettes that described a peer experiencing depression and alcohol misuse, respectively, and completed the General Help-Seeking Questionnaire as well as a 10-item scale measuring stigmatising attitudes. Past helping behavior was also assessed.Results:Compared to depression, a peer experiencing alcohol misuse was more likely to be considered “weak” rather than sick, and was perceived as more dangerous and unpredictable. The “weak-not-sick” and “dangerousness” dimensions of stigma predicted weaker intentions to encourage help-seeking from informal sources, while ‘dangerousness’ predicted stronger intentions to encourage formal help-seeking. Both dimensions were associated with fewer instances of past helping behavior.Conclusion:Young people stigmatise alcohol misuse more severely than depression. Overall, stigma was associated with weaker intentions to encourage peers to seek help. While perceptions of ‘dangerousness’ were associated with stronger intentions to seek help from formal sources, this association may not translate into actual helping behavior.