bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertensive Encephalopathy Triggered by Indomethacin Use
Authors: Plitman Jane , Raco Vanessa , Wu Peter E. 
Published: November 2024

ABSTRACTWe present the case of a man in his 70s who developed acute confusion from hypertensive encephalopathy triggered by indomethacin. He was recently prescribed indomethacin, a non‐steroidal anti‐inflammatory drug (NSAID) for headaches. However, his headaches were in the context of worsening hypertension that was treated with trandolapril. The use of indomethacin consequently worsened his underlying condition. On presentation to the emergency department, his blood pressure was 190/110 mmHg. Bloodwork including electrolytes, glucose, metabolic studies, renal and liver function were within normal limits; infectious workup including blood and urine cultures subsequently returned negative; and brain computed tomography and magnetic resonance imaging revealed no acute process to explain his presentation. Indomethacin was discontinued and the patient's hypertension was treated with amlodipine. Both his confusion and underlying headaches resolved as his blood pressure normalized. The patient was diagnosed with hypertensive encephalopathy triggered by indomethacin. NSAID use can trigger blood pressure decompensation, especially in patients with underlying hypertension; this effect is particularly pronounced in patients treated with anti‐hypertensive medications that inhibit the renin‐angiotensin‐aldosterone (RAS) system. Symptomatic treatment with NSAIDs is not without potential harm; it is important to carefully consider a patient's underlying diagnosis, indication for therapy and risk for adverse effects.
Meso‐β Monofused Porphyrins: Synthesis, Structural, Spectral, Electrochemical and DFT Studies and Their Efficient Third‐Order Nonlinear Optical Properties
Authors: Sohel Bulbul Amir , Jangra Reena , Kuriakose Albin , Nath Acharyya Jitendra , Vijaya Prakash G. , Sankar Muniappan 
Published: November 2024

AbstractThree new series of β‐to‐ortho‐phenyl monofused porphyrins, denoted as MMFP(MN)X2 (where MFP=monofused porphyrin, MN=malononitrile and X=H or Br) and MMFP(MN)MB (where MB=mono benzo, M=2H, Co(II), Cu(II) and Zn(II)) were designed and successfully synthesized with good yields. These compounds were thoroughly characterized using various spectroscopic techniques and single crystal X‐ray diffraction (SCXRD) analysis. Notably, three of the monofused porphyrins; CoMFP(MN)Br2, CuMFP(MN)Br2 and ZnMFP(MN)MB crystallized unambiguously in a triclinic crystal system with a
space group. The twist angle values for these structures ranged from 14.03° to 21.35°. The meso‐β peripheral fusion and substituents led to tunable electronic spectral features across the synthesized porphyrins. The first reduction and oxidation potentials of all the investigated monofused porphyrins exhibited significant anodically shift as compared to their parent tetraphenylporphyrins (TPPs), attributed to peripheral fusion and electron‐withdrawing substituents, which collectively led to a reduced HOMO–LUMO gap. Ultrafast third‐order nonlinear optical (NLO) studies revealed that these monofused porphyrins showed a strong two‐photon absorption coefficient (β=0.18–39.06×10−11 m/W) and effective cross‐section (
=0.03–8.05×105 GM) values along with self‐defocusing negative nonlinear refraction behaviour (n2=(−)0.5–5.28×10−16 m2/W). These findings open new avenues for the application of meso‐β fused porphyrins in optical limiters, optical devices and other optoelectronic applications.
A systematic review and meta‐analysis of patient‐relevant outcomes in comprehensive cancer centers versus noncomprehensive cancer centers
Authors: Thamm Carla , Button Elise , Johal Jolyn , Knowles Reegan , Gulyani Aarti , Paterson Catherine , Halpern Michael T. , Charalambous Andreas , Chan Alexandre , Aranda Sanchia , Taylor Carolyn , Chan Raymond J. 
Published: November 2024

AbstractThis systematic review describes difference in patient‐relevant outcomes between comprehensive cancers (CCCs) versus non‐CCCs. Studies were identified in PubMed, Cochrane CENTRAL, Epistemonikos, and gray literature from January 2002 to May 2024. Data were extracted and appraised by two authors. Results were narratively synthesized, and meta‐analyzed where appropriate. Of 2272 records screened, 36 observational studies were included, predominantly from the United States, and focused on adults with solid cancers. Compared to non‐CCCs, studies consistently or predominantly reported superior outcomes at CCCs relating to mortality and survival, quality of peri‐ and postoperative care, rates of cancer recurrence or progression, and impact on symptoms and health‐related quality of life. Meta‐analysis showed a significantly lower overall mortality risk of 23% in CCCs compared to non‐CCCs (hazard ratio, 0.77; 95% confidence interval, 0.74–0.81, p < .001), with medium heterogeneity (I2 = 64.61%; Q‐test = 36.29, p < .01) observed between the studies. Studies reporting on health equity and costs outcomes consistently or predominantly favored non‐CCCs over CCCs. Mixed results were reported for outcomes relating to time to care, palliative and end‐of‐life care, and health care utilization. The literature reports CCCs are associated with superior outcomes in many areas, especially around mortality and survival. Greater focus is needed to explore outcomes that are important to people with cancer including health‐related quality of life, symptoms, and treatment experience, and economic evaluation. Rather than aiming for superior outcomes, CCCs should be striving to enable equitable, high value, patient‐centered outcomes for all people affected by cancer.
The Combination of Graphitic Carbon Nitride (gC3N4) and Supercritical Carbon Dioxide for Green Photooxidation of Benzylic Alcohols
Authors: Merkulov Vladislav G. , Turova Olga V. , Ivanova Elizaveta A. , Kuchurov Ilya V. , Zharkov Mikhail N. , Zlotin Sergei G. 
Published: November 2024

AbstractThe research focuses on the innovative use of graphite‐like carbon nitride (gC3N4) catalysts along with supercritical carbon dioxide (scCO2) for the green synthesis of valuable organic compounds. Having explored different synthetic routes for gC3N4 and the obtained samples efficiency in the photocatalytic oxidation of benzyl alcohol with molecular oxygen in scCO2, we identified the most effective catalyst bearing ether linkers between layers of a graphite‐like structure. This catalyst facilitates the production of benzaldehyde and benzoic acid derivatives, highlighting the potential for sustainable industrial applications. The study's emphasis on a metal‐free catalyst and a zero‐waste process underlines its contribution to environmentally friendly chemical practices. The proposed approach offers a more sustainable and efficient alternative to traditional processes in small‐scale chemical production.
Scientometric and content analysis‐based review of employees in micro‐level corporate social responsibility research
Authors: Alfa Atia Alpha , Aryee Raphael , Manu Franklyn , Kpekpena Israel 
Published: November 2024

AbstractIn today's fiercely competitive business climate, organisations face challenges that necessitate the implementation of policies to bolster their strategic advantage, regardless of their size or location. One effective strategy employed by present‐day organizations to attain enhanced effectiveness and competitive edge is corporate social responsibility (CSR). This study presents a comprehensive scientometric analysis evaluating current research on micro‐level CSR. This investigation provides valuable insight into current micro‐level CSR research. Utilizing a science mapping method, 4286 Scopus bibliographic records were quantitatively and systematically examined. The findings reveal the most prolific authors, journals, institutions, countries, article citations and co‐occurrence network of keywords via cluster analysis. Additionally, the qualitative analysis uncovered five distinct micro‐level themes concerning CSR, including concepts, drivers, evaluations, reactions, and research design. This study is the first of its kind, and its findings add valuable insights to the existent knowledge. It provides an exhaustive and current literature review of micro‐level CSR. Trends and patterns of the micro‐level CSR field are visualized and comprehended, and the primary research networks, journals, institutions, and countries, along with their interconnections are identified. Furthermore, it introduces a comprehensive framework that classifies the different categories of micro‐level CSR research. Lastly, it highlights the inadequacies in current research and offers insights for future studies. This study will serve as a point of reference for policymakers, practitioners, and research and development agencies.
Association between locomotor muscle quality and cardiac function during exercise in heart failure with preserved ejection fraction
Authors: Sharif Salaheddin M. , Smith Joshua R. , Borlaug Barry A. , Olson Thomas P. 
Published: November 2024

AbstractAimsMuscle quality (MQ) is used to assess skeletal muscle function; however, the relationship between MQ and cardiac function during exercise in heart failure with preserved ejection fraction (HFpEF) is unknown. Therefore, the study aimed to determine the relationship between locomotor MQ and cardiac function during exercise in HFpEF.Methods and resultsA total of 22 HFpEF patients and 23 healthy matched controls (CTL) were recruited. Body composition including leg lean mass percentage (LL%) was measured by dual‐energy X‐ray absorptiometry. Cardiopulmonary exercise testing was performed and peak oxygen uptake (VO2) was measured. Cardiac output (CO) was measured via the open‐circuit acetylene wash‐in technique, heart rate by electrocardiogram, and cardiac power output (CPO) was calculated. Blood pressure was measured manually and mean arterial pressure (MAP) was calculated. MQ was calculated as peak watts divided by LL%. LL% was significantly lower in HFpEF than in CTL (p < 0.05). At peak exercise, workload, VO2, CO, and CPO were significantly lower in HFpEF (p < 0.05 for all). MQ was significantly lower in HFpEF than in CTL (1.6 ± 0.4 vs. 2.3 ± 0.6 W/%, p < 0.0001). MQ was positively correlated with CO (r = 0.51), CPO (r = 0.72) and MAP (r = 0.64) in HFpEF (p < 0.05 for all) but not in CTL.ConclusionOur data suggest MQ is closely related to cardiac function at peak exercise in HFpEF. These data suggest that MQ may be a useful tool for understanding exercise performance in HFpEF.
Knowledge and application of ESC/HFA guidelines in the management of advanced heart failure
Authors: Baudry Guillaume , Girerd Nicolas , Cikes Maja , Crespo‐Leiro Maria Generosa , Damman Kevin , Delmas Clément , Adamopoulos Stamatis , Nalbantgil Sanem , Lim Hoong Sern , Ruschitzka Frank , Metra Marco , Gustafsson Finn 
Published: November 2024

AimsManagement of advanced heart failure (HF) remains challenging despite specific sections in the 2021 European Society of Cardiology/Heart Failure Association (ESC/HFA) guidelines, with delays in referrals exacerbating the issue. This study aimed to evaluate the awareness and implementation of these guidelines among cardiologists and identify barriers to effective referral.Methods and resultsFrom June to October 2023, an online survey was disseminated through the ESC mailing list, targeting cardiologists across Europe. The survey investigated four areas: guideline awareness, healthcare network organization, clinical case management, and perceptions of mechanical circulatory support (MCS) outcomes. Respondents were categorized into heart failure cardiologists (HFCs), general cardiologists (GCs), and other participants (OPs). Among 497 respondents, 25% were heart HFCs, 40% were GCs, and 35% were OPs. A total of 84% of HFCs reported a high level of guideline knowledge, compared to 57% of GCs and 62% of OPs (p < 0.001). Additionally, 76% of HFCs ‘regularly or always’ used ESC/HFA criteria to identify advanced HF, compared to 44% of GCs and 48% of OPs (p < 0.001). Correct responses regarding the recommendation class for heart transplantation were 84%, 55%, and 60% (p < 0.0001), and for MCS as a bridge to transplantation, 69%, 65%, and 55% (p = 0.018) among HFCs, GCs, and OPs, respectively. Referring patients with severe HF to a tertiary centre team was found to be ‘very difficult’ or ‘difficult’ by 8.4% of HFCs, 19.6% of GCs, and 18.2% of OPs (p = 0.0005).ConclusionThe study highlights significant disparities in knowledge and application of advanced HF guidelines among cardiologists, revealing an opportunity for educational initiatives. The difficulty in referring patients to tertiary centres underscores the need to improve the referral pathway for advanced HF patients.
Electrochemical Determination of 17‐α‐Ethinylestradiol on a Graphene Quantum Dots and Carbon‐Black‐Modified Glassy Carbon Electrode
Authors: da Silva Araujo Mayara , de Matos Roberto , Tarley Cesar Ricardo Teixeira , Medeiros Roberta Antigo 
Published: November 2024

A simple and inexpensive electrochemical sensor based on a glassy carbon electrode (GCE) modified with graphene quantum dots and carbon black nanoparticles (dihydrogen phosphate polyelectrolyte) is applied to determination of the emerging contaminant the estrogen 17‐α‐ethinylestradiol (EE2). The combination of this nanocomposite with the GCE has not yet been explored as an electrochemical sensor. Combined, these materials create a synergy that enhances the overall performance of the oxidative detection system, resulting in a more efficient and accurate detection. The analytical curve presents a linear dynamic range from 0.998 to 10.0 µmol L−1, with a detection limit of 0.998 µmol L−1. Addition and recovery studies are carried out on a lake water sample, showing a recovery of 92.3%. The accuracy of the developed method is also evaluated by determining EE2 in pharmaceutical formulation samples. The obtained results are in statistical agreement with those obtained using high‐performance liquid chromatography–diode array detector at a confidence level of 95%. Therefore, the electrochemical sensor developed presents a fast construction procedure and the electroanalytical method for EE2 determination proves to be precise and accurate, with low consumption of reagents and a low relative cost.
Forecasting Realized Volatility: The Choice of Window Size
Authors: Feng Yuqing , Zhang Yaojie 
Published: November 2024

ABSTRACTDifferent window sizes may produce different empirical results. However, how to choose an ideal window size is still an open question. We investigate how the window size affects the predictive performance of volatility. The empirical results show that the loss function for volatility prediction takes on a U‐shape as the window size increases. This suggests that if the window size is chosen too large or too small, the loss function tends to be large and the model's predictive accuracy decreases. A window size of between 1000 and 2000 observations is ideal for various assets because it can produce relatively minimal forecast errors. From an asset allocation perspective, a mean–variance investor can obtain sizeable utility by using a model with a low loss function value for her portfolio. Moreover, the results are robust in a variety of settings.
Instruction to support word‐level reading skills for adolescent learners with learning disabilities
Authors: Chandler Brennan W. , Toste Jessica R. , Hart Elizabeth J. , Kearns Devin M. 
Published: November 2024

AbstractThe middle and high school years represent a unique challenge for students who have not yet attained proficiency with word reading. By this time, it is generally expected that students will be able to independently read a variety of texts to gain content knowledge and to read for understanding. Students with or at‐risk for learning disabilities (LD) often struggle with acquisition of word‐level reading skills and these difficulties are amplified as words become increasing complex. By fifth grade, most of the new words introduced in text are multisyllabic, yet students often lack a systematic approach for decoding these words. Despite these challenges, teachers can effectively support secondary‐aged students with LD in developing the foundational word reading skills necessary for reading proficiency. In this article, we describe the critical role of word reading efficiency, unique challenges of multisyllabic word reading, and the importance of ongoing instructional support for students with LD. We then introduce four instructional routines that can be implemented to facilitate secondary students' acquisition of word‐level reading skills that also affirm and strength students' diverse cultural and linguistic backgrounds.
Increases of Compound Hot Extremes Will Significantly Amplify the Population Exposure Risk Over the Mid–High Latitudes of Asia
Authors: Jiang Wenhao , Chen Huopo , Wang Huijun 
Published: November 2024

ABSTRACTBased on Coupled Model Intercomparison Project phase 6 (CMIP6) simulations, we found that the frequency and intensity of daytime–nighttime compound hot extremes (HEs) in the mid‐high latitudes of Asia (MHA) are expected to increase. The most significant increase is anticipated under the shared socioeconomic pathway (SSP) 5‐8.5, while the smallest increase is expected under SSP1‐2.6. Notably, unlike the decreasing trends of independent HEs since 2050 under the high emission scenarios, the compound HEs, which comprise the largest proportion, are expected to continuously increase and intensify. To better understand the impact of these changes on human society, we also focused on changes in population exposed to HEs. The findings reveal that population exposure to compound and nighttime HEs is projected to increase most rapidly under SSP3‐7.0, with estimates indicating increases of 10.06 and 3.80 times, respectively, by the end of the century. The most significant increases are expected in the mid‐latitudes, where changes in HEs are most pronounced. Climate change is the primary driver behind the rising population exposure to compound and nighttime HEs, with its impact expected to grow over time. Conversely, exposure to daytime HEs is primarily influenced by population changes, particularly in urban areas. Therefore, effective climate change mitigation and adaptive strategies are crucial to reducing future population exposure to HEs in MHA.
Interpersonal Psychotherapy for the Treatment of Depression in Parkinson's Disease: Results of a Randomized Controlled Trial
Authors: Koszycki Diana , Taljaard Monica , Bradwejn Jacques , Lee Caroline , Tasca Giorgio A. , Grimes David A. 
Published: November 2024

AbstractBackgroundDepression is a common nonmotor complication in Parkinson's disease (PD). However, few studies have evaluated the efficacy of first‐line psychological therapies for depression in this patient population.ObjectivesThis randomized controlled trial evaluated the efficacy of interpersonal psychotherapy (IPT), an empirically validated intervention for depression that focuses on the bidirectional relationship between mood disturbance and interpersonal and social stressors. A secondary aim was to assess maintenance of treatment gains at 6‐month follow‐up.MethodsParticipants with PD stages I to III and a comorbid depressive disorder were randomly assigned to 12 sessions of IPT (n = 32) or supportive therapy (ST) (n = 31), our active control intervention. The primary outcome was the Hamilton Depression Rating Scale (HAM‐D) administered blindly by telephone. Secondary outcomes included self‐report depression and anxiety, quality of life, clinician‐rated motor symptom, interpersonal relationships, and attachment style.ResultsIPT compared to ST resulted in a greater reduction in posttreatment HAM‐D scores (least square mean difference = −3.77, 95% confidence interval [CI]: −6.19 to −1.34, P = 0.003) and was associated with a greater odds of meeting remission (odds ratio = 3.23, 95% CI: 1.10–9.51, P = 0.034). The advantage of IPT over ST on HAM‐D scores and remission rates was not sustained at the 6‐month follow‐up. Both treatments improved self‐report depression, anxiety, quality of life, and aspects of interpersonal functioning.ConclusionsThis trial demonstrates the benefits of acute treatment with IPT in reducing depressive symptoms in PD. Clinicians should consider psychotherapy, alone or in combination with medication, as an important treatment option for PD depression. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Artification‐Based Philanthropy at Ornellaia: “Vendemmia d’artista” Supports the “Mind's Eye” Program of the Guggenheim Museum
Authors: Cito Maria Cristina , Veronesi Vittoria 
Published: November 2024

ABSTRACTThis paper investigates the role of artification‐based philanthropy in enhancing brand authenticity and addressing the luxury brand paradox through the case study of Ornellaia's Vendemmia d’artista project. The infusion of art undoubtedly enhances brand perception, particularly for luxury brands that seek to reinforce prestige and exclusivity. On the other hand, philanthropy is a powerful tool to improve brand image by demonstrating the brand's genuine commitment to the common good and strengthening its symbolic value. Thus, for luxury brands, artification‐based philanthropy can be challenging due to the contradiction between the goal of philanthropic activity and the essence of luxury and exclusivity reinforced by art. Through in‐depth qualitative interviews with managers and analysis of internal documents, we investigated the Vendemmia d’artista project as an excellent example of how different initiatives can overcome this contradiction. Particularly, these initiatives include engaging in meaningful dialogue with stakeholders and the public, firmly establishing a strong connection with the brand identity, and committing to long‐term engagement with artists and the Solomon R. Guggenheim Foundation. The article outlines the proper use of artification‐based philanthropy in sectors where brand authenticity is essential for gaining legitimacy among the public and stakeholders. Additionally, it suggests managers prioritize unwavering commitment, strengthened by aligning multiple activities engaging diverse audiences.
Artification in the Industrial Sector: Exploring Florim Ceramiche's Integration of Art Into Business
Authors: Ricci Alessandra , Massara Francesco , Matteo Francesco De 
Published: November 2024

ABSTRACTThis study examines the concept of artification within the industrial sector, focusing on Florim Ceramiche, a leading Italian ceramic manufacturer. While artification has been extensively explored in the luxury and fashion industries, its application in industrial contexts remains under‐researched. Using a case study approach, we investigate the processes and factors involved in artification at Florim, producing its impact on external outcomes, such as brand identity enhancement and market results. Key findings reveal that Florim's artification is supported by a top–down governance approach that reflects corporate values. A trust‐based partnership between Florim and collaborating artists further enhances the cultural authenticity of the artification process. Artification is also an inside–out process underpinned by physical artworks that enrich the workplace environment and promote employee well‐being, aligning with corporate social responsibility (CSR) objectives. The process operates through concentric engagement, starting internally with employees and extending to visitors and the local community. This research highlights artification's potential to foster both social sustainability and brand differentiation, providing insights for managers in the industrial sector aiming to integrate art within CSR frameworks.