bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additional studies in Neobertiera (Rubiaceae, Sipaneeae): a new species from the state of Pará, Brazilian Amazon, and a new combination for a species from French Guiana
Authors: DELPRETE PIERO G. 
Published: February 2019

In a recent revision of Neobertiera, three new species were described and the distylous condition of this genus was reported for the first time. In the present paper, a new species, N. montedouradensis, from the state of Pará, Amazon Basin, is described, which represents a significant range extension and the first record of this genus for Brazil. This new species is unique within the genus by having hypanthia and fruits with trichomes conspicuously tuberculate at base. In addition, a new combination is proposed for a species from French Guiana recently named N. glomerata. A correction regarding the corolla size of N. pakaraimensis is included. In view of these taxonomic novelties, a key to the five species of Neobertiera is provided.
Community Forums to Address the Opioid Crisis: An Effective Grassroots Approach to Rural Community Engagement
Authors: Palombi Laura , Olivarez Michelle , Bennett Laura , Hawthorne Amanda N 
Published: February 2019

Purpose: With opioid overdose deaths on the rise in rural Minnesota and across the nation, the call for community-based grassroots efforts is stronger than ever. Recognizing that substance use prevention and recovery programming rely upon community resources, collaborative teams planned and implemented a series of nine community forums focused on opioid and heroin use across rural northeast Minnesota to educate and unite invested community members on the critical public health issue. This article examines the outcomes of the forums and the ingredients of a successful forum. Methods: Surveys were distributed at seven rural community forums to assess measures of growth in knowledge and awareness, as well as demographic characteristics of respondents. Findings: Forums planned by university faculty and community members were effective in increasing overall awareness and knowledge of the opioid crisis within each community. Forums that were rated more highly by attendees included speakers from varied professional backgrounds and integrated cultural strengths. Communities that planned forums together have reported increased collaboration to prevent and address substance use and increased community member engagement on local grassroots coalitions since the time of the forum. Conclusions: Community forums have functioned as an effective grassroots approach to engaging rural community members in opioid use prevention and intervention efforts.
Postprandial Plasma Amino Acid Responses Between Standard Whey Protein Isolate and Whey Protein Isolate Plus Novel Technology
Authors: Sharp Matthew H , Stefan Matthew W , Lowery Ryan P , Wilson Jacob M 
Published: February 2019

Background: Muscle mass is an important determinant of metabolic health and physical function. It has previously been demonstrated that the postprandial rise in circulating essential amino acids (EAA) acts as the main stimulus for muscle protein synthesis (MPS). This study investigated postprandial plasma amino acid (AA) responses of 2 different forms of whey protein isolate (WPI) with iso-caloric and iso-nitrogenous profiles to investigate plasma concentrations of EAA. Methods: In all, 12 healthy men (n = 12) between 19 and 32 years of age were recruited for a randomized, cross-over design, which involved consumption of protein supplements on 2 testing days separated by a 6-day washout period between conditions. On each testing day, subjects consumed either 29.6 g of WPI or WPI + io (whey protein isolate plus Ingredient Optimized Protein®) mixed with 236 mL of water. Plasma EAA and branch chain amino acid (BCAA) concentrations were assessed from whole body donated by subjects at pre-consumption and 30, 60, 90, 120, and 180 minutes post consumption. Results: Plasma levels of total EAA concentration was significantly greater in WPI + io at 30, 60, 90, and 120 minutes post consumption ( P < .01, P < .001, P < .01, and P < .01, respectively). Plasma levels of total BCAA concentration was significantly greater in WPI + io at 30, 60, 90, and 120 minutes post consumption ( P < .01, P < .001, P < .01, and P < .05, respectively) compared with WPI. For leucine, only WPI + io had elevated levels compared with pre-test at 90 minutes post consumption ( P < .001). Discussion: Both conditions significantly elevated EAA, BCAA, and leucine from basal levels. However, we conclude that the consumption of the treated WPI significantly raises plasma EAA, BCAA, and leucine to a greater extent compared with WPI with no treatment. Thus, supplementation with WPI that has undergone Ingredient Optimized® technology may be highly beneficial for those who partake in regular exercise, elderly individuals, or those affected by a reduced sensitivity to amino acids.
Predicting Long-Term Mortality, Morbidity, and Survival Outcomes Following a Cardiac Event: A Cardiac Rehabilitation Study
Authors: Graham Helen L , Lac Andrew , Lee Haeok , Benton Melissa J 
Published: February 2019

Background: Cardiac rehabilitation (CR) has been shown to decrease mortality and morbidity but estimations vary. While there is significant literature supporting short-term benefits, there is not a similarly body of research as to long-term (LT) benefits. Low participation rates in CR are due to several causes and evidence demonstrating positive LT outcomes could be a catalyst to increased participation rates. Objective: To predict LT mortality, readmission, and survival benefits associated with CR participation in a nationally certified program. Methods: Investigators collected mortality and hospital readmission data in a retrospective study to examine a cohort of cardiac patients following a myocardial infarction (MI), MI/percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) up to 14 years ago. Hospital electronic medical record (EMR; n = 207) were used to measure hospital readmission outcome and State Health Department records (n = 361) for mortality and survival outcomes. Participation in CR, age, gender prior history of cardiac event, and diagnosis were used to predict readmission, mortality, and survival. Results: Approximately half (52.1%) the sample participated in CR. Participants included 72% males, average age 68 years (38-91 years), and were predominantly Non-Hispanic white. CR participants attended an average of 20 sessions. CR group differed in diagnoses MI (58.5%), CABG (57.4%) and in prior history of heart disease (25.4%) from the non-cardiac rehabilitation (NCR) group (83.2%, 25.4%, 42.2%, respectively) ( P < .05). After controlling for the covariates in logistic regression analyses, the CR group independently predicted lower all-cause mortality (odds ratio, OR = 0.22, 95% CI 0.12 to 0.39) and decreased hospital readmissions (OR = 0.48, 95% CI 0.24 to 0.96). After controlling for the covariates in survival analysis, the CR group significantly contributed to decreased likelihood of death hazard (hazard ratio = 0.36, 95% CI 0.24 to 0.54). Median survivor time for the participants was 5.91 years, SD = 3.81 years. Conclusions: Participation in CR for middle age and elderly patients is associated with increased survival, a marked decrease in all-cause mortality, and a decrease in cardiovascular-related hospital readmission. A referral to a nationally certified outpatient CR program prior to hospital discharge and early enrollment may improve LT outcomes.
Patterns and Mechanisms of Political Participation among People with Disabilities
Authors: Powell Sierra , Johnson April A. 
Published: February 2019

Abstract
Context: Previous research has shown that Americans with disabilities turn out to vote at significantly lower levels than people without disabilities, even after accounting for demographic and other situational factors related to political involvement. The authors examined the potential mechanisms underlying their low turnout. They asked whether people with disabilities exhibit participatory attitudes and behaviors at levels commensurate with their other individual-level characteristics.
Methods: The present study conducted descriptive and predictive analyses on data from the 2012 and 2016 American National Election Studies.
Findings: Despite low levels of turnout in recent elections, people with disabilities were just as participatory, if not more so, when considering alternative forms of political engagement. The authors' analyses indicate that, while disability status had no bearing on political efficacy or partisan strength, those with disabilities reported being even more interested in politics than those without disabilities. Evidence is provided that depressed turnout rates among those with disabilities may be due in part to lower levels of attentiveness to the news, political knowledge, and negative perceptions of government.
Conclusions: The psychological impacts and behavioral consequences that emerge from possessing a disability and the broader role of disability in the American political context are multifaceted. This area of research would benefit from future studies that examine a variety of electoral contexts.
Prediction of the Blood-Brain Barrier Permeability Using RP-18 Thin Layer Chromatography
Authors: Sobańska Anna W. , Wanat Karolina , Brzezińska Elżbieta 
Published: February 2019

AbstractThe Blood-Brain Barrier (BBB) permeability is an important factor governing a drug’s ability to act upon the Central Nervous System. The measure of the BBB permeability used throughout this study is the log BB (the blood/brain partitioning coefficient) measuredin vivoor calculated. Useful yet simple models of the BBB permeability were developed by Stepwise Multiple Regression Analysis based on the chromatographic parametersRfandRf/PSAobtained by RP-18 TLC with acetonitrile - pH 7.4 phosphate buffered saline 70:30 (v/v) as mobile phase, combined with descriptors - the number of H-bond donors (HD), the number of H-bond acceptors (HA), energy of the highest occupied molecular orbital – (eH), energy of the lowest unoccupied molecular orbital (eL). The ability of the solutes to cross the BBB has been studied qualitatively using Discriminant Function Analysis. Almost all compounds with the knownBB vivoparameter were correctly classified as CNS+/-. The classification functions based onRf/PSAhave been verified using an external group. The results of the chromatographic analysis proposed in this study (RP-18 TLC) are a source of valuable information on the BBB permeability of compounds available even on a very small scale.
Scaffolding clinical reasoning of medical students with virtual patients: effects on diagnostic accuracy, efficiency, and errors
Authors: Braun Leah T. , Borrmann Katharina F. , Lottspeich Christian , Heinrich Daniel A. , Kiesewetter Jan , Fischer Martin R. , Schmidmaier Ralf 
Published: February 2019

Abstract

Background
Understanding clinical reasoning is a major challenge in medical education research. Little is known about the influence of scaffolding and feedback on the clinical reasoning of medical students. The aim of this study was to measure the effects of problem representation (cognitive representation of a clinical case) and structured scaffolding for reflection with or without feedback on the diagnostic efficiency and characterization of diagnostic errors of medical students.

Methods
One hundred and forty-eight advanced medical students were randomly assigned to one of five groups (2 × 2 design with a control group). They worked on 15 virtual clinical cases (five learning cases, five initial assessment cases, and five delayed assessment cases) in an electronic learning environment. After each case, they stated their presumed diagnosis and explained their diagnostic conclusion. Diagnostic accuracy, efficiency, and error distribution were analyzed.

Results
The diagnostic accuracy (number of correctly solved cases) and efficiency (solved cases/total time) did not differ significantly between any of the groups in the two different assessment phases [mean = 2.2–3.3 (standard deviation [SD] = 0.79–1.31), p = 0.08/0.27 and mean = 0.07–0.12 (SD = 0.04–0.08), p = 0.16/0.32, respectively]. The most important causes for diagnostic errors were a lack of diagnostic skills (20%), a lack of knowledge (18%), and premature closure (17%).

Conclusions
Neither structured reflections nor representation scaffolding improved diagnostic accuracy or efficiency of medical students compared to a control group when working with virtual patients.
Rao-Blackwellizing field goal percentage
Authors: Daly-Grafstein Daniel , Bornn Luke 
Published: February 2019

Abstract
Shooting skill in the NBA is typically measured by field goal percentage (FG%) – the number of makes out of the total number of shots. Even more advanced metrics like true shooting percentage are calculated by counting each player’s 2-point, 3-point, and free throw makes and misses, ignoring the spatiotemporal data now available (Kubatko et al. 2007). In this paper we aim to better characterize player shooting skill by introducing a new estimator based on post-shot release shot-make probabilities. Via the Rao-Blackwell theorem, we propose a shot-make probability model that conditions probability estimates on shot trajectory information, thereby reducing the variance of the new estimator relative to standard FG%. We obtain shooting information by using optical tracking data to estimate three factors for each shot: entry angle, shot depth, and left-right accuracy. Next we use these factors to model shot-make probabilities for all shots in the 2014–2015 season, and use these probabilities to produce a Rao-Blackwellized FG% estimator (RB-FG%) for each player. We demonstrate that RB-FG% is better than raw FG% at predicting 3-point shooting and true-shooting percentages. Overall, we find that conditioning shot-make probabilities on spatial trajectory information stabilizes inference of FG%, creating the potential to estimate shooting statistics earlier in a season than was previously possible.
Discrete Wavelet Packet Transform Based Discriminant Analysis for Whole Genome Sequences
Authors: Huang Hsin-Hsiung , Girimurugan Senthil Balaji 
Published: February 2019

AbstractIn recent years, alignment-free methods have been widely applied in comparing genome sequences, as these methods compute efficiently and provide desirable phylogenetic analysis results. These methods have been successfully combined with hierarchical clustering methods for finding phylogenetic trees. However, it may not be suitable to apply these alignment-free methods directly to existing statistical classification methods, because an appropriate statistical classification theory for integrating with the alignment-free representation methods is still lacking. In this article, we propose a discriminant analysis method which uses the discrete wavelet packet transform to classify whole genome sequences. The proposed alignment-free representation statistics of features follow a joint normal distribution asymptotically. The data analysis results indicate that the proposed method provides satisfactory classification results in real time.
Orozomukoid és sziálsav – szerkezet, funkció, klinikai vonatkozások
Authors: Jakab Lajos 
Published: February 2019

Abstract: The work focuses on orosomucoid. First, the biological role and the development of this essential molecule is summarized, then the formation of its special molecular structure is introduced. After the summary of the specific characteristics and the physiological, pathophysiological as well as clinical properties of orosomucoid and sialic acid, their most important roles are also presented. Orosomucoid belongs to the family of lipocalins and the subfamily of immunocalins – this determines its immunological, anti-inflammatorical and transporting capacities. Another important quality of the molecule is that it is recognized by lectins. Orosomucoid is highly bioactive. More knowledge is increasing about its function and biological role. The clinical relations are summarised, too. Orv Hetil. 2019; 160(8): 283–290.
Ritka szisztémás gyógyszer-interakció: timololtartalmú szemcsepp és lerkanidipintabletta együttes alkalmazása során ismétlődően jelentkező syncope
Authors: Kun Edit , Dienes Lóránt , Simonyi Gábor , Finta Ervin 
Published: February 2019

Abstract: The control and planning of the treatment of hypertensive patients need specific attention. As regards concomitant diseases and treatments, glaucoma and the use of eye drops should be taken into consideration. The ingredients of the administered eye drops get through the nasolacrimal canal and can be absorbed by the nasal mucosa. Because of the lack of enterohepatic ‘first pass’ effect, they can act systemically – like after intravenous administration. This way they can cause systemic side effects. The authors present a case of a patient, too, who was examined and medically checked regularly for years with negative results because of repeated syncope. It became clear only at the Hypertension Centre that the timolol-containing combined eye drops caused the symptoms. The authors draw attention to the fact that in the case of systemic side effects which can be connected to beta-blocking agents (blood pressure fall, bradycardia, breathing disturbance, depression), the role of the eye drops should be taken into consideration. At the same time, the possibility of the systemic drug interactions should not be forgotten either. The interaction with dihydropyridine-type calcium-channel blockers can be of great importance. In these cases, after consultation with an ophthalmologist, the glaucoma treatment with eye drops containing beta-blockers should be modified. Orv Hetil. 2019; 160(8): 309–313.
A hyponatraemia klinikai jelentősége
Authors: Vígh József , Ábrahám György , Kálmán János , Zöllei Magdolna , Forster Tamás 
Published: February 2019

Abstract: Hyponatremia is a most common disorder of electrolytes encountered in everyday clinical practice. Although many cases are mild and relatively asymptomatic, hyponatremia is nonetheless important clinically because of the potential for substantial morbidity and mortality. Despite the knowledge of hyponatremia since the mid-20th century, this common disorder remains incompletely understood in many basic areas because of its causation by multiple etiologies with differing pathophysiological mechanisms. Up to this time, the optimal treatment strategies have not been well defined. The authors present 3 typical hypotonic hyponatremic patients for colleages in clinical practice for studying, for establishing a common conception for the managing of hyponatremia. Orv Hetil. 2019; 160(8): 314–319.
A hidradenitis suppurativa nőgyógyászati vonatkozásai
Authors: Kiss Norbert , Plázár Dóra , Lőrincz Kende , Bánvölgyi András , Valent Sándor , Wikonkál Norbert 
Published: February 2019

Abstract: Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicles, usually presenting after puberty on the apocrine gland-bearing areas of the body. It usually flares up periodically and can lead to a severe condition affecting the 20–40-year-old childbearing age group. HS occurs more commonly in women. The main clinical features consist of painful, cicatrizing nodules and abscesses which develop mostly in the axillary, inguinal, genital and perianal regions and also on the breasts. HS is often accompanied by severe pain and malodorous discharge, both of which cause significant psychological stress and social stigma. Our main aim with this review paper is to highlight the gynecological aspects of this disease, as many times – due to the typical localization of the disease – patients seek gynecological care first when they experience the first symptoms of this disease. The most important classification of HS is the Hurley scale, which is based on the severity of the clinical symptoms. In recent years, numerous clinical trials have been conducted to seek optimized care of HS patients. Several drugs are used for the treatment of HS, but in most cases, the treatment has to be switched many times. It is of great importance to carefully follow comorbidities and possible pregnancies as in these cases, careful selection of treatment is required. Thus, HS is not only a dermatological, but also a gynecological disease. With an appropriate treatment and follow-up, the disease can be effectively handled. Orv Hetil. 2019; 160(8): 291–299.
The impact of adjuvant radiotherapy on the outcome of immediate breast reconstruction after mastectomy in breast cancer patients
Authors: Romanenkov Nikolay Sergeevich , Movchan Konstantin N. 
Published: February 2019

Background. Data allowing to estimate the impact of postoperative radiotherapy on the possibility of prosthetic breast reconstruction with silicone implants or tissue expanders are mainly presented in single-level retrospective cohort studies.
Material and methods. We searched for scientific papers in English published from January 1, 2000 to September 30, 2018 in the PubMed/MEDLINE database. The study parameters included demographic data, the method of breast reconstruction, information about adjuvant radiotherapy parameters, the incidence of postoperative complications.
Results and discussion. Having studied the data about immediate prosthetic breast reconstruction with silicone implant or a tissue expander performed after mastectomy in 3,654 breast cancer patients. The complications after surgery were reported in 40% of all clinical observations. In 15% of cases, the specialists stopped the attempts to perform breast reconstruction. In general, the aesthetic results of immediate prosthetic breast reconstruction performed before postop radiotherapy are far from being perfect. Nevetheless, most patients are satisfied with them after the surgery.
Conclusion. Adjuvant radiotherapy has a negative impact on the results of immediate prosthetic breast reconstruction after mastectomy. Despite this, the need for radiotherapy should not be regarded as an absolute contraindication for the immediate breast reconstruction with silicone implants and tissue expanders.
The Correlation between Fat Consumption and Atherogenic Index on Type 2 Diabetes Melitus Patients in dr. Soebandi Hospital
Authors: Ratnasari Mega , Santosa Ali , Rahmawati Dwita Aryadina 
Published: February 2019

One of the risk factor that can be changed in type 2 diabetes melitus is food consumption. Fat is one of the macronutrients that have significant influence in consumption. Unhealthy diet can be a trigger to macrovascular complication that is coronary heart disease (CHD) which started with atherosclerosis. Atherogenic index is a good predictor for CHD. This study aims to determine the correlation between fat consumption with atherogenic index in DMT 2 patients at RSD dr. Soebandi. This is an analitic observational study with cross sectional design, using 74 type 2 diabetes melitus patients from Internal Poly at RSD dr. Soebandi who met inclusion and exclusion criteria. Fat consumption were obtained with 24-hours food recall interview and atherogenic index were obtained from TG and HDL levels in medical record. The average of fat consumption is 34,01% and as much 33 subjects (44,6%) have high risk of CHD (AI>0,21). Spearman correlation test between fat consumption with atherogenic index is p=0,025 which mean there is significant correlation between fat consumption and atherogenic index in type 2 diabetes melitus patients at RSD dr. Soebandi
Keywords: DM Type 2, fat consumption, carbohydrate consumption, atherogenic index