bluuebunny/crossref_metadata_2025_split huggingface dataset:
Session V: Macro Perspectives: Bigger Problems than Corporate Governance
Authors: Greenwald Bruce , Mitts Joshua , Phelps Edmund 
Published: September 2019

Columbia Business School's well‐known authority on value‐based investing begins by attributing today's economic problems to a “global economic dislocation,” one that is rooted in the ongoing—and in Greenwald's view, inevitable—decline of manufacturing and displacement by services. Like the other example of dislocation in modern times, the Great Depression of the 1930s, the 2008 global financial crisis and protracted recession— still very much with us—are viewed as originating in the sharp decline of a major “sector” of the global economy. In the Depression of the ‘30s it was agriculture; in the recent financial crisis it was manufacturing. In both cases, technological advances and economy‐wide productivity increases led to huge increases in stock and financial asset prices—but also to sharp drops in the prices of farm and manufactured goods, and massive overcapacity and ruinous competition in both sectors.According to the author, the working off of overcapacity in the agricultural sector was accomplished largely by the effect of World War II in moving huge numbers off the farm and into the mainly urban industrial sector at government expense. This labor force relocation, which occurred in all developed economies, was essential to a global economic transformation that for the next 50 years provided high productivity growth and greater equality of income and wealth.More recently, however, the global economy has been confronted with the challenge of accomplishing a transition from manufacturing to services that will feature lower productivity growth and more inequality. Foreseeing a long, difficult process, Greenwald's biggest concern is that government intervention will distract businesses from making this transition effectively—which means continuing to operate as efficiently as possible, downsizing when necessary—and so make the problems worse. And while business focuses on preserving its own efficiency and value, Greenwald urges governments to look for more cost‐effective ways—for example, expanded use in the U.S. of the Earned Income Tax Credit—to cushion workers from the consequences. Nobel laureate Edmund Phelps, while agreeing with much of Greenwald's analysis, has a different explanation of the U.S. productivity dilemma. Innovation is viewed as the primary driver of the prosperity of the advanced economies. Higher income and wealth matter less than job satisfaction, participation, and an array of non‐material “modern values” that have somehow been lost and that, for Phelps, are the key to restoring economic growth and “mass flourishing.”
The Case for Maximizing Long‐Run Shareholder Value
Authors: Denis Diane 
Published: September 2019

Criticism of the shareholder model of corporate governance stems in part from misunderstanding about what shareholder wealth maximization means for the other stakeholders of public companies. The corporate goal of shareholder wealth maximization does not imply that such stakeholders “do not matter.” Managers maximize shareholder value by maximizing the total expected cash flows available to distribute to all of their stakeholders. To maximize such cash flows, managers must provide their customers with desirable goods and services at attractive prices—which in turn requires that managers attract the employees, suppliers, and financial capital needed to conduct their businesses by providing each of these groups with market‐determined returns on their contributions to firm value. In this way, successful corporations benefit all of their stakeholders, and what is good for the corporation is generally good for society.External forces such as the media and government exert considerable influence on corporate actions and, in so doing, they play a role in helping to limit negative corporate “externalities” such as pollution and climate change. But direct regulation of productive activities should be used sparingly, and subjected to ongoing cost‐benefit analysis. Government regulation replaces the collective decisions of a broad marketplace of stakeholders using their own resources to act in their own interests with decisions made by government officials with complicated incentives and using resources generated by others. More generally, government should seek to regulate corporate actions only in the limited situations in which there are no market solutions for reducing the effects of externalities. For example, government plays a critically important role in identifying and deterring corporate fraud, and in ensuring competition and a level playing field for companies and all their stakeholders.
Beyond EVA
Authors: Milano Greg 
Published: September 2019

A former partner of Stern Stewart begins by noting that the recent acquisition of EVA Dimensions by the well‐known proxy advisory firm Institutional Shareholder Services (ISS) may be signaling a resurgence of EVA as a widely followed corporate performance measure. In announcing the acquisition, ISS said that it's considering incorporating the measure into its recommendations and pay‐for‐performance model.While applauding this decision, the author also reflects on some of the shortcomings of EVA that ultimately prevented broader adoption of the measure after it was developed and popularized in the early 1990s. Chief among these obstacles to broader use is the measure's complexity, arising mainly from the array of adjustments to GAAP accounting. But even more important is EVA's potential for encouraging “short‐termism”—a potential the author attributes to EVA's front‐loading of the costs of owning assets, which causes EVA to be negative when assets are “new” and can discourage managers from investing in the business.These shortcomings led the author and his colleagues to design an improved economic profit‐based performance measure when founding Fortuna Advisors in 2009. The measure, which is called “residual cash earnings,” or RCE, is like EVA in charging managers for the use of capital; but unlike EVA, it adds back depreciation and so the capital charge is “flat” (since now based on gross, or undepreciated, assets). And according to the author's latest research, RCE does a better job than EVA of relating to changes in TSR in all of the 20 (non‐financial) industries studied during the period 1999 through 2018.The article closes by providing two other testaments to RCE's potential uses: (1) a demonstration that RCE does a far better job than EVA of explaining Amazon's remarkable share price appreciation over the last ten years; and (2) a brief case study of Varian Medical Systems that illustrates the benefits of designing and implementing a customized version of RCE as the centerpiece for business management. Perhaps the most visible change at Varian, after 18 months of using a measure the company calls “VVA” (for Varian Value Added), has been a sharp increase in the company's longer‐run investment (not to mention its share price) while holding management accountable for earning an adequate return on investors’ capital.
The role of microvesicles and its active molecules in regulating cellular biology
Authors: Lv YingMei , Tan Jin , Miao Yuyang , Zhang Qiang 
Published: September 2019

AbstractCell‐derived microvesicles are membrane vesicles produced by the outward budding of the plasma membrane and released by almost all types of cells. These have been considered as another mechanism of intercellular communication, because they carry active molecules, such as proteins, lipids and nucleic acids. Furthermore, these are present in circulating fluids, such as blood and urine, and are closely correlated to the progression of pathophysiological conditions in many diseases. Recent studies have revealed that microvesicles have a dual effect of damage and protection of receptor cells. However, the nature of the active molecules involved in this effect remains unclear. The present study mainly emphasized the mechanism of microvesicles and the active molecules mediating the different biological effects of receptor cells by affecting autophagy, apoptosis and inflammation pathways. The effective ways of blocking microvesicles and its active molecules in mediating cell damage when microvesicles exert harmful effects were also discussed.
Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis
Authors: Clementini Marco , Ambrosi Alessandro , Cicciarelli Valerio , De Risi Valeria , de Sanctis Massimo 
Published: September 2019

AbstractAimTo assess the effectiveness, in terms of clinical performance and patient perception, of minimally invasive periodontal surgeries (MIPSs), and to compare MIPSs to traditional surgery in the treatment of periodontal infrabony defects.Materials and MethodsAn electronic search and a manual search were carried out to identify studies investigating clinical (CAL, PPD, REC), radiographic (bone fill) and patient's centred (VAS) outcomes at least 6 months after MIPSs. A linear mixed‐effect model was used for meta‐analysis. Subgroup analyses were performed according to the study quality (RCT or case series). A meta‐analysis assessing differences in clinical parameters between MIPSs and traditional flaps was also performed.ResultsMeta‐analysis from the 18 included studies revealed a PPD reduction of 4.24 mm (95% CI = 3.79–4.69 mm), a CAL gain of 3.89 mm (95% CI = 3.42–4.35 mm), a REC increase of 0.44 mm (95% CI = 0.11–0.77 mm), a radiographic bone fill gain of 58.25% (95% CI = 42.30%–74.21%) and a VAS value of 1.16 (95% CI = 0.78–1.54). Based on 2 RCTs, MIPSs are more effective than traditional surgery for PPD reduction (0.93 mm, 95% CI = 1.71–0.15) and CAL gain (1 mm, 95% CI = 1.75–.24).ConclusionMinimally invasive periodontal surgeries may be considered for the treatment of periodontal infrabony defects. However, the real effect cannot be systematically evaluated due to the paucity of studies comparing MIPSs to traditional flap for periodontal reconstructive surgery.
Immune response to chronic Toxocara canis infection in a mice model
Authors: Ruiz‐Manzano Rocío Alejandra , Hernández‐Cervantes Rosalía , Del Río‐Araiza Víctor Hugo , Palacios‐Arreola Margarita Isabel , Nava‐Castro Karen Elizabeth , Morales‐Montor Jorge 
Published: September 2019

AbstractAimsThe zoonotic nematode Toxocara canis causes larva migrans syndrome that induces an immune response characterized by the production of antibodies and eosinophilia. A Th2 polarization has been associated with the infection, but there are still details of the cellular and humoral immune response that need to be described. Thus, the aim of this study was to describe the systemic host immune response to T canis chronic infection in a mouse model.Methods and ResultsBALB/c mice were inoculated once with 500 T canis embryonated eggs, per os. After 49 days, the amounts of larval found in brain and muscle tissues were statistically two and four times higher, respectively, than the amounts found in lung, liver, kidney or heart tissues. Splenic proportions of F4/80+ cells, as well as B, cytotoxic T and CD4+Foxp3+ lymphocytes, were statistically higher (P ≤ .05, P ≤ .01, P ≤ .001 and P ≤ .001, respectively) as compared with control mice. In lymph nodes, some of these proportions changed, with the exception of F4/80+ cells. IgG1 levels in infected mice sera were increased. IL‐4, IL‐10 and VEGF levels were statistically higher in spleen (P ≤ .05, all) and sera (P ≤ .01, P ≤ .05 and P ≤ .05, respectively) in the infected mice. Also, in infected animals, IL‐5 serum levels were increased (P ≤ .01).ConclusionThese results suggest that T canis chronic infection in BALB/c mice results in a type 2 response with an incipient regulatory response.
Immune mechanisms in human and canine demodicosis: A review
Authors: Gazi Umut , Taylan‐Ozkan Aysegul , Mumcuoglu Kosta Y. 
Published: September 2019

AbstractDemodex mites are saprophytic parasites of the mammalian skin, mostly found in or near pilosebaceous units of hairy regions. While they can be found in healthy humans and animals without causing any clinical manifestations, they were suggested to create pathogenic symptoms when they appear in high densities under favourable conditions (ie, demodicosis). Nevertheless, their role as the primary causative agent of the pathogenic conditions in humans is debated today. Canine demodicosis, which is highly prevalent in certain dog breeds, provides a valuable tool for studying the pathogenesis of human demodicosis. Canine and human demodicosis are caused by different Demodex species, and the clinical manifestations in former could be life‐threatening. Nevertheless, current literature suggests similar immune responses and immune evasion mechanisms in human and canine demodicosis; cellular immunity appeared to have a central role in protection against demodicosis, and Demodex mites were shown to influence both innate and adaptive immune response to escape immune attack. The aim of this review is to summarize the relevant literature on demodicosis obtained from studies conducted on both organisms, and draw the attention to the effect of mite‐associated factors (eg, microbiota) on the different clinical manifestations displayed during human and canine demodicosis.
Detection of Echinococcus granulosus sensu lato infection by using extracts derived from a protoscoleces G1 cell line
Authors: Maglioco Andrea , Gentile Jorge , Barbery Venturi Melisa S. , Jensen Oscar , Hernández Claudia , Gertiser María Laura , Poggio Verónica , Canziani Gabriela , Fuchs Alicia Graciela 
Published: September 2019

AbstractCystic echinococcosis (CE) can be diagnosed by means of several serological approaches, but their results vary among laboratories due to the molecular characteristics of the reference antigens used. Thus, this study aimed to address both the relevance of an EGPE cell line previously obtained from Echinococcus granulosus protoscoleces G1 and the complexity of the immune response by using two different in vitro growth stages as separate sources of parasite antigens. The serum reactivity was investigated by western blotting (WB) in 21 CE patients from an endemic area in a matched case‐control design and also in seven experimentally infected sheep and five healthy control sheep. EGPE‐antigen‐human serum sensitivity by WB was higher than that of hydatid fluid (HF) WB, ELISA and DD5 (P < .05, Chi‐square test). EGPE protein extract was immunogenic in mice and hyperimmune plasma reacted with HF proteins, and AgB2 expression was detected by molecular analysis. Proteins of 37 to 60 kDa were recognized by 95.24% of the CE patients’ sera but, with poor specificity. Statistically significant differences were found between serum protein extract recognition at 7 and 20 days of cell growth. The EGPE cell line is a laboratory source of antigens for improvement of CE serological diagnosis.
Turbulent Flame Shape Switching at Conditions Relevant for Gas Turbines
Authors: Langella Ivan , Heinze Johannes , Behrendt Thomas , Voigt Lena , Swaminathan Nedunchezhian , Zedda Marco 
Published: September 2019

Abstract
A numerical investigation is conducted to shed light on the reasons leading to different flame configurations in gas turbine (GT) combustion chambers of aeronautical interest. Large eddy simulations (LES) with a flamelet-based combustion closure are employed for this purpose to simulate the DLR-AT big optical single sector (BOSS) rig fitted with a Rolls-Royce developmental lean burn injector. The reacting flow field downstream this injector is sensitive to the intricate turbulent–combustion interaction and exhibits two different configurations: (i) a penetrating central jet leading to an M-shape lifted flame; or (ii) a diverging jet leading to a V-shaped flame. The LES results are validated using available BOSS rig measurements, and comparisons show the numerical approach used is consistent and works well. The turbulent–combustion interaction model terms and parameters are then varied systematically to assess the flame behavior. The influences observed are discussed from physical and modeling perspectives to develop physical understanding on the flame behavior in practical combustors for both scientific and design purposes.
A Study on the Leakage and Rotordynamic Coefficients of a Long-Smooth Seal With Laminar-Two-Phase, Mainly-Oil Mixtures
Authors: Zhang Min , Childs Dara W. , Tran Dung L. , Shrestha Hari 
Published: September 2019

Abstract
This paper conducts a comprehensive study on the effects of the presence of air in the oil on the leakage and rotordynamic coefficients of a long-smooth seal (inner diameter D = 89.306 mm, radial clearance Cr = 0.140 mm, and length-diameter ratio L/D = 0.65) under laminar-two-phase flow conditions. The mixture consists of air and silicone oil with inlet gas volume fraction (GVF) up to 10%. Tests are performed at inlet temperature Ti = 39.4 °C, exit pressure Pe = 6.9 bars, pressure drop PD = 31, and 37.9 bars, and rotor speed ω = 5, 7.5, and 10 krpm. The test seal is always concentric with the rotor, and no intentional fluid prerotation is provided at the seal inlet. The complex dynamic stiffness coefficients Hij of the test seal are measured and fitted by the frequency-independent direct stiffness K, cross-coupled stiffness k, direct damping C, cross-coupled damping c, direct virtual-mass M, and cross-coupled virtual-mass mq coefficients. Under laminar flow conditions, increasing inlet GVF has negligible effects on K, k, C, and effective damping Ceff, while it decreases c and M. These trends are correctly predicted by San Andrés's bulk-flow model with laminar flow friction formula. As inlet GVF increases, measured leakage flow rate m˙ increases slightly. In general, the predictions of K, k, C, c, Ceff, and m˙ are reasonably close to measurements.
A Study for Rotordynamic and Leakage Characteristics of a Long-Honeycomb Seal With Two-Phase, Mainly Air Mixtures
Authors: Zhang Min , Childs Dara W. 
Published: September 2019

Abstract
This paper investigates the impact of the oil (silicone oil PSF-5cSt) presence in the air on the leakage and rotordynamic characteristics of a long-honeycomb seal with length-to-diameter ratio L/D = 0.748 and diameter D = 114.656 mm. Tests are carried out with inlet pressure Pi = 70.7 bars, pressure ratio (PR) = 0.35 and 0.25, inlet liquid volume fraction (LVF) = 0%, 3.5%, and 7%, and shaft speed ω = 10, 15, and 20 krpm. During the tests, the seal is centered. Test results show that leakage mass flow rate m˙ increases (as expected) as inlet LVF increases. Increasing inlet LVF makes direct stiffness K increase more rapidly with increasing excitation frequency Ω. Increasing inlet LVF has a negligible effect on K at low Ω values, but increases K at high Ω values. The value of effective damping Ceff at about 0.5ω is an indicator to the system stability since an unstable centrifugal compressor rotor can precess at about 0.5ω. Increasing inlet LVF increases the value of Ceff at about 0.5ω, reducing the possibility of subsynchronous vibrations (SSVs) at about 0.5ω. San Andrés's model is used to produce predictions. The model assumes that the test fluid in the seal clearance is an isothermal-homogenous mixture. The model adequately predicts m˙, K, and the value of Ceff at about 0.5ω.
Numerical Investigation of Shape Effect on Microdroplet Evaporation
Authors: Shan Li , Shuai Shuai , Ma Binjian , Du Zichen , Dogruoz Baris , Agonafer Damena 
Published: September 2019

Abstract
As electronic devices continue to shrink in size and increase in functionality, effective thermal management has become a critical bottleneck that hinders continued advancement. Two-phase cooling technologies are of growing interest for electronics cooling due to their high heat removal capacity and small thermal resistance (<0.1 k cm2/W). One typical example of a two-phase cooling method is droplet evaporation, which can provide a high heat transfer coefficient with low superheat. While droplet evaporation has been studied extensively and used in many practical cooling applications (e.g.,, spray cooling), the relevant work has been confined to spherical droplets with axisymmetric geometries. A rationally designed evaporation platform that yields asymmetric meniscus droplets can potentially achieve larger meniscus curvatures, which gives rise to higher vapor concentration gradients along the contact line region, and therefore, yields higher evaporation rates. In this study, we develop a numerical model to investigate the evaporation behavior of asymmetrical microdroplets suspended on a porous micropillar structure. The equilibrium profiles and mass transport characteristics of droplets with circular, triangular, and square contact shapes are explored using the volume of fluid (VOF) method. The evaporative mass transport at the liquid–vapor interface is modeled using a simplified Schrage model. The results show highly nonuniform mass transport characteristics for asymmetrical microdroplets, where a higher local evaporation rate is observed near the locations where the meniscus has high curvature. This phenomenon is attributed to a higher local vapor concentration gradient that drives faster vapor diffusion at more curved regions, similar to a lightning rod exhibiting a strong electric field along a highly curved surface. By using contact line confinement to artificially tune the droplet into a more curved geometry, we find that the total evaporation rate from a triangular-based droplet is enhanced by 13% compared to a spherical droplet with the same perimeter and liquid–vapor interfacial area. Such a finding can guide the design and optimization of geometric features to improve evaporation in advanced microcooling devices.
Measurements and Modeling of the Movement Behavior of a Radial Adaptive Seal
Authors: Beermann Laura , Wilhelm Julius , Bauer Hans-Jörg 
Published: September 2019

Abstract
The radical change in the energy market with a raising share of renewable energy production leads to new operating cycles in turbo machinery. The machines must be optimized for frequent transient load cycles and part load utilization. New radial adaptive sealing concepts in the secondary air system can help to increase part load efficiency and achieve a long service life. These seals are pressure-activated and adapt their gap width during operation. The sealing concepts have to be analyzed in more detail to fully understand their operational behavior. In this paper, a model to understand and predict the movement of a radial adaptive seal called hydrostatic advanced low leakage (HALO) seal is presented. Experimental results of the gap width, leakage, and pressure distribution are used in combination with two-dimensional (2D) computational fluid dynamics (CFD) to obtain force distributions across the seal for static operation. These data are used to derive a model to predict the forces acting on the seal as well as the operational gap width, which is necessary for a reliable seal design.