bluuebunny/crossref_metadata_2025_split huggingface dataset:
IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells
Authors: Agostini-Dreyer Allyson , Jetzt Amanda E , Skorupa Jennifer , Hanke Jennifer , Cohick Wendie S 
Published: December 2018

Abstract
IGF-binding protein (IGFBP)-3 is a multifunctional protein that can exert IGF-independent effects on apoptosis. Anisomycin (ANS) is a potent inducer of IGFBP-3 production in bovine mammary epithelial cells (MECs), and knockdown of IGFBP-3 attenuates ANS-induced apoptosis. IGFBP-3 is present in the nucleus and the conditioned media in response to ANS. The goal of this study was to determine whether ribotoxic stress induced by ANS or a second ribotoxin, deoxynivalenol (DON), specifically regulates transport of IGFBP-3 to the nucleus and to determine the pathway by which it traffics. In ribotoxin-treated cells, both endogenous IGFBP-3 and transfected IGFBP-3 translocated to the nucleus. Inhibition of the nuclear transport protein importin-β with importazole reduced ribotoxin-induced nuclear IGFBP-3. Immunoprecipitation studies showed that ANS induced the association of IGFBP-3 and importin-β, indicating that ribotoxins specifically induce nuclear translocation via an importin-β‒dependent mechanism. To determine whether secretion of IGFBP-3 is required for nuclear localization, cells were treated with Pitstop 2 or brefeldin A to inhibit clathrin-mediated endocytosis or overall protein secretion, respectively. Neither inhibitor affected nuclear localization of IGFBP-3. Although the IGFBP-3 present in both the nucleus and conditioned media was glycosylated, secreted IGFBP-3 exhibited a higher molecular weight. Deglycosylation experiments with endoglycosidase Hf and PNGase indicated that secreted IGFBP-3 completed transit through the Golgi apparatus, whereas intracellular IGFBP-3 exited from the endoplasmic reticulum before transit through the Golgi. In summary, ANS and DON specifically induced nuclear localization of nonsecreted IGFBP-3 via an importin-β‒mediated event, which may play a role in their ability to induce apoptosis in MECs.
Radtools: R utilities for smooth navigation of medical image data
Authors: Russell Pamela H. , Ghosh Debashis 
Published: December 2018

The radiology community has adopted several widely used standards for medical image files, including the popular DICOM (Digital Imaging and Communication in Medicine) and NIfTI (Neuroimaging Informatics Technology Initiative) standards. These file formats include image intensities as well as potentially extensive metadata. The NIfTI standard specifies a particular set of header fields describing the image and minimal information about the scan. DICOM headers can include any of >4,000 available metadata attributes spanning a variety of topics. NIfTI files contain all slices for an image series, while DICOM files capture single slices and image series are typically organized into a directory. Each DICOM file contains metadata for the image series as well as the individual image slice. The programming environment R is popular for data analysis due to its free and open code, active ecosystem of tools and users, and excellent system of contributed packages. Currently, many published radiological image analyses are performed with proprietary software or custom unpublished scripts. However, R is increasing in popularity in this area due to several packages for processing and analysis of image files. While these R packages handle image import and processing, no existing package makes image metadata conveniently accessible. Extracting image metadata, combining across slices, and converting to useful formats can be prohibitively cumbersome, especially for DICOM files. We present radtools, an R package for smooth navigation of medical image data. Radtools makes the problem of extracting image metadata trivially simple, providing simple functions to explore and return information in familiar R data structures. Radtools also facilitates extraction of image data and viewing of image slices. The package is freely available under the MIT license at https://github.com/pamelarussell/radtools and is easily installable from the Comprehensive R Archive Network (https://cran.r-project.org/package=radtools).
Estimated Nonreimbursed Costs for Care Coordination for Children With Medical Complexity
Authors: Ronis Sarah D. , Grossberg Richard , Allen Rabon , Hertz Andrew , Kleinman Lawrence C. 
Published: December 2018

BACKGROUND AND OBJECTIVES:
Multidisciplinary care teams may improve health and control total cost for children with medical complexity (CMC). We aim to quantify the time required to perform nonreimbursed care coordination activities by a multidisciplinary care coordination program for CMC and to estimate the direct salary costs of that time.

METHODS:
From April 2013 to October 2015, program staff tracked time spent in practicably measured nonbilled care coordination efforts. Staff documented the discipline involved, the method used, and the target of the activity. Cost was estimated by multiplying the time spent by the typical salary of the type of personnel performing the activity.

RESULTS:
Staff logged 53 148 unique nonbilled care coordination activities for 208 CMC. Dietitians accounted for 26% of total time, physicians and nurse practitioners 24%, registered nurses 29%, and social workers 21% (1.8, 2.3, 1.2, and 1.4 hours per CMC per month per full-time provider, respectively). Median time spent in nonreimbursed care coordination was 2.3 hours per child per month (interquartile range 0.8–6.8). Enrollees required substantially greater time in their first program month than thereafter (median 6.7 vs 2.1 hours per CMC per month). Based on 2015 national salary data, the adjusted median estimated cost of documented activities ranged from $145 to $210 per CMC per month.

CONCLUSIONS:
In this multidisciplinary model, care coordination for CMC required substantial staff time, even without accounting for all activities, particularly in the first month of program enrollment. Continued advocacy is warranted for the reimbursement of care coordination activities for CMC.
May-Thurner syndrome and varicose veins of the pelvic organs in men
Authors: Kapto A. A. 
Published: December 2018

The study objectiveis to study the methods of diagnosis and treatment of iliac venous compression in men with urological and andrological pathology and varicose veins of the pelvic organs.Materials and methods. From 2015 to 2018, 110 patients with bilateral varicocele, varicose veins of the pelvic organs and May–Thurner syndrome in age from 17 to 69 years (mean 33.2 years) were examined. Ultrasound echography of the scrotum organs and vessels of the penis, including transrectal and Doppler mode, magnetic resonance phlebography, dynamic pharmacocavernosography were used for the examination.Results.The presence of bilateral varicocele in all patients was verified. Aorto-mesenteric compression in combination with iliac venous compression was detected in 36 (32.7 %) patients. X-ray surgical treatment of ileal venous compression syndrome was performed in 26 patients. After 3 months in all cases there was a decrease in the maximum diameter of the veins of the prostate gland. In 13 patients with isolated ileal compression (without combination with arterial aorto-mesenteric forceps), by 3 months after surgery, a reduction in varicocele was observed: in all cases the diameter of the left and right testicular veins lying and without tension was less than 2 mm.Conclusion.Angioplasty and stenting of the iliac veins in arterio-venous conflicts is a highly effective method of treating patients with varicose veins of the pelvic organs in combination with varicocele.
Phytopreparations in complex treatment of patients with benign prostatic hyperplasia and erectile dysfunction
Authors: Bat’ko A. B. 
Published: December 2018

The study objectiveis to evaluate clinical effectiveness of a phytopharmaceutical Vialissil® for treatment of patients with benign prostatic hyperplasia (BPH) and erectile dysfunction.Materials and methods. At the multi-specialty clinic “Family Doctor” (Saint Petersburg) 34 patients aged from 55 to 67 years (mean age 59.6 + 0.7 years) with BPH and concomitant erectile dysfunction without the need for surgical intervention were examined. All patients received previously prescribed symptomatic therapy for BPH and erectile dysfunction (a-adrenoblockers and phosphodiesterase type 5 inhibitors on demand). The treatment group included 18 patients who additionally received Vialissil® as capsules once a day for 30 days. The remaining 16 patients were the control group.Results.After treatment, intensity of general symptoms decreased more in the treatment group than in the control group (by 10 and 4 points, respectively). After the course of therapy, erectile function improved in both groups but only in the treatment group these dynamics were statistically significant. An increase in testosterone level was statistically significant only after combination therapy with Vialissil® (by 16.5 %), and blood level of biologically accessible (active) testosterone increased twofold.Conclusion.Combination therapy for BPH and erectile dysfunction including administration of the Vialissil® phytopharmaceutical more effectively decreases disease intensity compared to standard therapy.
Connection of urethral microbiota with the semen quality and the concentration of endocrine disrupters in men semen
Authors: Chigrinets S. V. , Bryuhin G. V. 
Published: December 2018

The study objective is to investigate the correlations between opportunistic microorganisms of the urethra and the quality of ejaculate, as well as the concentration of ubiquitory endocrine disruptors (bisphenol A and triclosan) in men semen.Materials and methods. We analysed 63 semen samples of men with normo- and patozoospermia. In seminal fluid the concentration of bisphenol A and triclosan was determined by gas chromatography with mass spectrometry. The microbiocenosis of the urethra was studied by real-time polymerase chain reaction using the Androflor test system. The results were subjected to statistical processing using the Mann — Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant.Results. Bisphenol A was found in 100 % of the semen samples. Triclosan was detected in 84.9 % of the samples. Comparison groups on the quality of ejaculate (normo- and pathozoospermia) were statistically significantly different in the concentration of bisphenol A and triclosan in seminal fluid (p <0.001) and (p = 0.003) respectively. The study established statistically significant correlations between bisphenol A concentration, seminal triclosan and urethral microbiota: Lactobacillus spp. (r = 0.501, p = 0.003), Corynebacterium spp. (r = 0.425, p = 0.015), Anaerococcus spp. (r = 0.371, p = 0.045), Eubacterium spp. (r = 0.357, p = 0.037) for bisphenol A and Staphylococrns spp. (r = 0.392, p = 0.026), Streptococcus spp. (r = —0.486, p = 0.005) for triclosan.Conclusion. In this study the connection of the urethral microbiota with the quality of the ejaculate and the concentration of endocrine dis-ruptors (bisphenol A and triclosan) in men semen was established. In this regard, it is necessary to take into account the role of asymptomatic urethral dysbiosis when administering patients with poor ejaculate quality.
Polineoplasia in patients with cervical cancer in the Chelyabinsk region of Russia
Authors: Bekhtereva S. A. , Domogirova A. S. , Vazhenin A. V. , Aksenova I. A. 
Published: December 2018

The purpose of the study was to analyze the incidence of primary-multiple cancer (PMC) of the female reproductive system according to the population cancer register of the Chelyabinsk region for 15 years (1999-2013) using the example of PMC of the cervix. Carry out an analysis of the adjusted cumulative survival in the group of patients with PMC of the cervix as compared with solitary cervical cancer.Material and methods. The material was processed using the classification of Zisman I. F. and Kirichenko G. D. (1978) on the sequence of tumors: metachronous, synchronous, mechatronic-synchronous and synchronous-metachronous. The interval of metachronousness is 6 months. The survival rates of cancer patients in the Chelyabinsk region were calculated automatically with the use of the computer program "Calculation of survival rates" — an application to the population-based cancer registry of OOO Novell-SPb. Using the method of continuous sampling, we carried out a retrospective analysis of the case histories of patients with PMC of the female reproductive system treated in the SBEO CRCOD for 15 years (1999-2013).Results. During the period under review, 82 patients with PMC of the cervix uteri were examined, metachronous tumors prevailed in 55 (67.1%), synchronous tumors developed in 27 (33.75%). In the group of metachronous tumors in 12 (21.8%) patients had a combination of three tumors. Three (5.45%) patients had a combination of four tumors. Analysis of combinations of cervical cancer showed that more often, the cervical cancer metachronically met with breast cancer 35% (14 patients), endometrial cancer 17.5% (7 patients), ovarian cancer 7.5% (3 patients). Synchronously cervical cancer was more often combined with breast cancer 42.8% (9 patients), endometrium 28.6% (6 patients), ovaries 23.8% (5 patients) and rectal cancer 4.8% (1 patient).The results of calculation of the index of the adjusted cumulative survival of the study group of the PMC of the cervix showed that in the group of metachronous tumors, survival rates were significantly higher than in the group of synchronous tumors: single-year survival was 84.8 ± 6.3% against 82.4 ± 9.2, three-year survival — 66.8 ± 7.8% against 47, 1 ± 12.1, and five years after the diagnosis, 53.8 ± 8.6% of patients survived.Conclusion. Thus, patients with cervical cancer are at risk of developing cancer of other localizations that share common etiopathogenetic factors, such as HPV infection in women, hormonal disorders.
Prediction of success in assisted reproductive technology with the help of morphology of the testis
Authors: Kulchenko N. G. 
Published: December 2018

In the structure of infertile marriage male factor of infertility occurs in about 40-50%. About 30% of infertile men who have sought medical care have oligozoospermia or azoospermia of unknown etiology. The question of the chances of spermatogenesis recovery and increased probability of sperm extraction in repeated assisted reproductive technology (ART) programs is important for both the doctor and the patient.Purpose. To evaluate the morphological changes of spermatogenic epithelium in patients with male infertility in terms of prognosis of ART success.Patients and methods. 264 men with infertility were examined. The scope of clinical study of all patients included: history, examination, determination of blood hormones, study of ejaculate, karyotype, ultrasound. We performed a biopsy of the testis according to the patient's symptoms. Testicular tissue was subjected to morphological examination.Results. Primary infertility was observed in 172 men (65.2%), secondary — 92 (34.8%). 112 (42.4%) patients had severe infertility. The results of morphological studies in these men showed a different degree of violation of spermatogenesis. Based on the study, a diagnostic algorithm of patients with male infertility is proposed, which allows to predict the success of ART taking into account morphological changes in the testicle.Conclusion. On the basis of clinical and morphological study of the features of spermatogenesis of a particular patient a plan can be made for further personal diagnostic and therapeutic measures.
Blunt trauma of the scrotum and testicle: algorithm of choice of treatment tactics
Authors: Yarovoy S. K. , Khromov R. A. 
Published: December 2018

Purpose of the study. The aim of this study is to improve the quality of emergency urological care for patients with scrotal and testicular trauma.Patients and methods. The study is a comparison of the results of prospective (according to the algorithm) and retrospective fragments, including a total of 459 patients (414 retrospectively, 45 prospectively). Patients received inpatient urological care for traumatic damage to the scrotum and testicle in D. Pletnyov City Clinical Hospital Department of Health of Moscow, N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology — Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation for the period 2008-2018.Results. The article analyzes the clinical effectiveness of the developed algorithm for the choice of therapeutic tactics in different variants of scrotal and testicular injuries. The key differences between the proposed algorithm and the generally accepted tactics are the extension of indications for emergency testicular revision (to operate with hematocele of any volume) and the same type of antibacterial prevention/therapy of infectious posttraumatic orchitis, regardless of the nature of the injury.Conclusion. When using the algorithm, the following clinical advantages were noted: reducing the likelihood of acute post-traumatic orchitis 2.4 times (p = 0,0271); reduced likelihood of postoperative infectious-inflammatory complications is reduced 2.0 times; reducing the likelihood of orchiectomy or hardening of the testicle 1.4 times.
Fen Bilimleri Öğretimi Öz Yeterlik Ölçeği: Geçerlik ve Güvenirlik Çalışması
Authors: GÖZÜM Ali İbrahim Can , GÜNEŞ Tohit 
Published: December 2018

Bu çalışmanın
amacı, fen öğretimi veya fen etkinlikleri yapılan ortamlardaki öğretmenlerin öz
yeterlik inanç düzeyini çeşitli değişkenlerle ölçme işlemi yapabilmek için bir
ölçme aracı geliştirmektir. Araştırmanın çalışma grubunu 2013-2014 yılları
arasında Kars il ve ilçe merkezinde görev yapmakta olan okul öncesi, sınıf ve
fen bilgisi öğretmenleri oluşturmaktadır.
Bu araştırma tarama modeline uygun ölçek geliştirme çalışmasıdır. Ölçme
aracının geliştirilmesi için uygun olan süreç sistematik olarak izlenmiştir.
Araştırmada elde edilen veriler uygun istatistiksel yöntemler kullanılarak
analiz edilmiştir. Ölçeğin kapsam geçerliğini tespit etmek için ilgili alan
yazın taranmış ve uzman görüşüne başvurulmuştur. Yapı geçerliği için açımlayıcı
faktör analizi (AFA) ve doğrulayıcı faktör analizi kullanılmıştır. Açımlayıcı
faktör analizi, Kars il merkezinde 90 okul öncesi, 188 sınıf ve 60 fen bilgisi
olmak üzere toplam 338 öğretmenin oluşturduğu çalışma grubuna uygulanmıştır.
Açımlayıcı faktör analizi yapılan ölçeğin 46 maddeden ve iki boyuttan oluştuğu
tespit edilmiştir. Bu boyutların ve ölçeğin geçerliliğin doğrulanması için doğrulayıcı
faktör analizi yapılmıştır. Doğrulayıcı faktör analizi, Kars ilçe merkezindeki
42 okul öncesi, 153 sınıf öğretmeni ve 55 fen bilgisi olmak üzere toplam 250
öğretmene uygulanmıştır. Yapılan geçerlilik çalışmaları sonucunda iki faktörlü
yapı olumlu öz yeterlik ve olumsuz öz yeterlik şeklinde adlandırılmıştır. Ölçeğin
güvenirlik çalışması için iç tutarlık katsayısı, madde toplam korelasyonu,
ayırt edicilik ve faktörler arasında anlamlı bir ilişki bulunup bulunmadığını
tespit etmek amacıyla pearson momentler çarpımı korelasyonu hesaplanmıştır. Ölçeğe
ait Cronbach alfa güvenirlik katsayısı ,946 iken olumlu öz yeterlik boyutu
katsayısının ,933 ve olumsuz öz yeterlik alt boyutuna ait katsayının ,920 olduğu
tespit edilmiştir. Bu bulgular ışığında ölçeğin, fen öğretimi ya da fen
etkinlikleri yapılan ortamlardaki bireylere ait öz yeterlik inancını geçerli ve
güvenilir şekilde ölçtüğü belirlenmiştir.
Bilinçli Farkındalık ve Algılanan Stres İlişkisinde Ruminasyon ve Olumsuz Duygu Düzenlemenin Aracı Rolü
Authors: Cenkseven Önder Fulya , Utkan Çağrı 
Published: December 2018

Araştırmada
üniversite öğrencilerinin bilinçli farkındalıkları ile algıladıkları stres
arasındaki ilişkide ruminasyon ve olumsuz duygudurum düzenlemenin aracılık rolünü
incelemek amaçlanmıştır. Araştırma 425’i
kadın (%57) ve 320’si erkek (%43) olmak üzere toplam 745 üniversite öğrencisi
üzerinde gerçekleştirilmiştir. Öğrencilerin yaş ortalaması 21.64’dür (Ss=2.77).
Araştırmada “Bilinçli Farkındalık Ölçeği”, “Algılanan Stres Ölçeği”, “Ruminatif
Düşünme Biçimi Ölçeği” ve “Olumsuz Duygudurum Düzenlemesi Ölçeği”
kullanılmıştır. Aracılık analizlerinde regresyon temelli aracılık makrosu
kullanılmıştır. Dolaylı etkilerin anlamlılığını incelemek için hem Sobel Z, hem
de bootstrapping prosedürü kullanılmıştır. Araştırma sonucunda Sobel Z testi ve
bootstrapping sonuçları hem ruminasyonun (Z= -6.99, p&lt;.001, Bootstrap
katsayısı= -.06, Sh= .01, %95 GA= -.09, -04) hem de olumsuz duygudurum
düzenlemenin (Z= -6.99, p&lt;.001, Bootstrap katsayısı= -.09, Sh= .01, %95 GA=
-.12, -07) bilinçli farkındalık ve algılanan stres arasındaki ilişkide kısmi
aracı role sahip olduğunu göstermiştir.
Okulların Fiziksel Donanım Yeterliliğinin Müzik, Beden ve Doğa Zekâ Alanları Açısından İncelenmesi
Authors: HOTAMAN Davut 
Published: December 2018

Okul,
öğrenme kuramlarındaki değişimlere göre kendini geliştirmek ve yenilemek
zorundadır. Bazı toplumlarda okula ve akademik bilgiye ilişkin tutumlar, gün
geçtikçe olumsuz bir hal almakta, bakımsız, sevimsiz, okul mimarisi yetersiz,
gerekli fiziksel donanımdan yoksun okullarda uzun ve sıkıcı bir öğrenme
sürecinin gerekliliği tartışma konusu olmaktadır. Bu durumun bir problem olarak
ele alınarak, okula karşı oluşan bu olumsuz tutumları ortadan kaldırarak okulun
gerekliliğini yeniden inşa etmek gerekmektedir. Okul bunu yaparken, gelişen
öğrenme kuramlarına paralel olarak kendisini gözden geçirerek, geliştirmek
zorundadır. Bu araştırma, nitel boyutlu bir durum çalışması
desenindedir. Bu araştırmada amaç, devlet okullarının sahip olduğu fiziksel donanımı, müzik, beden ve doğa zekâ
alanları açısından incelenmektir. Okulun
fiziksel donanımına ilişkin bilgiler yarı yapılandırılmış görüşme formu
kullanarak yönetici, yönetici yardımcılarından ve öğretmenlerden, Müzik, Beden ve Doğa Zekâ alanlarına
ilişkin kazanımlar ise, MEB Talim Terbiye Kurul Başkanlığının yeni öğretim
program kaynakları taranmak suretiyle elde edilmiştir. Araştırma yapılan İstanbul ili Esenler ve Güngören
ilçelerindeki yönetici görüşleri okulların Müzik,
Beden ve Doğa Zekâ alanlarını destekler nitelikte bir fiziksel donanıma
sahip olmadığı şeklinde oluşurken, öğretmen görüşleri de var olan fiziksel
donanımın ilgili zekâ alanlarına ait kazanımları etkili bir şekilde hayata
geçirmede yetersiz kaldığı yönünde oluşmuştur.
TEKDÜZEN MUHASEBE SİSTEMİNDE GERÇEKLİĞİ BOZAN HÜKÜMLER VE GÜNCELLEME İHTİYACI
Authors: DİNÇ Engin , ATABAY Esra 
Published: December 2018

Türkiye’de 26 yıldır yürürlükte olan
Tekdüzen Muhasebe Sistemi, muhasebe uygulama ve eğitimine birçok katkılar
sunmuştur. Ancak, mevcut tekdüzen muhasebe sisteminin gerçeğe uygunluk
açısından birçok eksiği mevcuttur. Bu da
muhasebe aracılığı ile üretilen finansal bilginin gerçeklikten uzaklaşmasına
neden olmaktadır. Bilginin çok değerli olduğu günümüzde, işletmelerin ihtiyaç
duyduğu gerçekçi bilginin üretilebilmesi için tekdüzen muhasebe sisteminin
yeniden güncellenmesi ve çağa uygun hale getirilmesi gerekmektedir. Bu
çalışmanın amacı; muhasebenin gerçeğe uygun bilgi üretmesinin önünde engel
olarak duran tekdüzen muhasebe sistemindeki hükümleri temel kavramlar, mali
tablo sunum ve içeriği, hesap planı ve değerleme hükümleri açısından incelemek ve
uygulamadaki yanlışlıkları tartışmaya açmaktır.