bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encysted hydrocele of the canal of Nuck in an 11-month-old child with a past history of duodenal atresia and Arnold-Chiari malformation
Authors: Zvizdic Zlatan , Milisic Emir , Chikha Adisa , Sefic Irmina , Dzananovic Amra , Vranic Semir 
Published: January 2019

Abstract

Rationale:
Hydrocele of the canal of Nuck is a rare developmental disorder and represents of a homolog of hydrocele of spermatic cord in males. Hydrocele of the canal of Nuck is a very rare cause of inguinal swelling in female infants and children. It results from the failure of obliteration of the distal portion of evaginated parietal peritoneum within the inguinal canal, which forms a sac containing fluid.

Patient concerns:
We describe a case of hydrocele of the canal of Nuck in an 11-month-old girl with a past medical history of duodenal atresia and Arnold-Chiari malformation.

Diagnosis:
Physical examination and ultrasound revealed a soft, cystic, noncompressible, and non-fluctuant labial mass measuring approximately 5 cm.

Interventions:
The patient underwent surgical exploration through a right skin crease incision. The cystic lesion was histologically confirmed to be a non-communicated hydrocele of canal of Nuck.

Outcomes:
The child is doing well at 1-year follow-up with no swelling or recurrence on the operated side.

Lessons:
Hydrocele of the canal of Nuck is a rare developmental disorder but should be considered in a differential diagnosis in young girls with an inguino-labial swelling.
Bilateral kidneys involvement of collecting duct carcinoma with cystic change
Authors: Gong Guanghui , Lin Ting , Yuan Yishu , Li Yulai , Liu Ruijie 
Published: January 2019

Abstract

Rationale
Collecting duct carcinoma (CDC) is a rare neoplasm arising from the collecting duct and should be distinguished from other renal cell carcinomas that mostly originated from the proximal tubular epithelium and tumors originated from the urothelium. It usually occurs in unilateral kidney, sometimes found with cystic change.

Patient concerns
We present the case of a 53-year-old male suffering from repeated bilateral flank pain for 6 months, increased pain with dysuria for 5 days.

Diagnosis
Ultrasound showed 2 similar hybrid echo masses in bilateral kidneys with enlarged lymph nodes surrounded, which accords with magnetic resonance imaging (MRI), and intraoperative biopsy reported malignancy.

Interventions
An exploratory operation was performed and the mass on the left kidney was removed, but pathological result reported collecting duct carcinoma according to the morphological features and immunohistochemical tests. Also postsurgery positron emission tomography-computed tomography (PET-CT) confirmed the mass on the left kidney is also a lesion of CDC.

Outcomes
The patient refused chemotherapy and had an overall survival of 7 months.

Lessons
We presented a case of CDC involving bilateral kidneys with cystic change; this is the first case of bilateral renal occurrence with cystic change to our knowledge. Because of CDC's rapid growth and the lack of effective adjuvant treatment after surgery, the prognosis is poor and the diagnosis should be made carefully.
A study of affecting the recovery of Chinese patients with Bell palsy
Authors: Zhang Hongbo , Du Haixia , Qian Mingjing , Wang Yu , Zhou Shenghua , Chen Jing , Wan Haitong , Yang Jiehong 
Published: January 2019

Abstract
We explored the risk factors for preventing recovery of Bell palsy (BP) in Chinese inpatients. Five hundred thirteen patients were included. The two end-points of assessment were the discharge and final follow-up results. Relationship between discharge and baseline: long patients delay (unhealed 4.03 ± 1.16 d vs improved 2.24 ± 1.0 d, P < .001), combined diseases (yes 77.06% vs no 86.71%, P = .01), and early use of acupuncture (yes 47.46% vs no 97.62%, P < .001) were bad factors. Therapeutic factors and discharge: only use of steroids was a positive factor (yes 92.54% vs no 57.30%, P < .001). Binary logistic regression found that early use of steroids was a favorable factor (P = .001), while early use of acupuncture (P < .001) and long patient delay (P < .001) were adverse factors. Subgroups analysis showed early use of steroids plus antivirals (steroids + antivirals vs antivirals + mecobalamin, P < .001) and early use of steroids plus mecobalamin were good choices (steroids + antivirals vs steroids + mecobalamin, P = .745), while early use of antivirals plus mecobalamin was a bad choice (vs other 2 groups, P < .001). Effect of drug dose and treatment course on discharge: long time use of steroids didn’t mean good efficacy (unhealed 10.80 ± 1.53 d vs improved 10.38 ± 1.21 d, P = .026). Final follow-up results: improved patients were better than that of unhealed at discharge (P < .001). Risk factors of discharge included long patient delay, combined diseases, and early use of acupuncture. Steroids plus antivirals or steroids plus mecobalamin were good choices for treatment. Long time use of steroids didn’t mean good effect. Improved patients at discharge had better results finally.
Widespread latitudinal asymmetry in marginal population performance
Authors: Pulido Fernando , Castagneyrol Bastien , Rodríguez-Sánchez Francisco , Cáceres Yónatan , Pardo Adhara , Moracho Eva , Kollmann Johannes , Valladares Fernando , Ehrlén Johan , Jump Alistair S. , Svenning Jens-Christian , Hampe Arndt 
Published: January 2019

AbstractAimRange shifts are expected to occur when populations at one range margin perform better than those at the other margin, yet no global trend in population performances at range margins has been demonstrated empirically across a wide range of taxa and biomes. Here we test the prediction that, if impacts of ongoing climate change on population performance are widespread, then populations from the high-latitude margin (HLM) should perform as well as or better than central populations, whereas populations at low-latitude margins (LLM) populations should perform worse.LocationGlobalTime period1898–2020Major taxa studiedPlants and animalsMethodsTo test our prediction, we used a meta-analysis quantifying the empirical support for asymmetry in the performance of high- and low-latitude margin populations compared to central populations. Performance estimates were derived from 51 papers involving 113 margin-centre comparisons from 54 species and 705 populations. We then related these performance differences to climatic differences among populations. We also tested whether patterns are consistent across taxonomic kingdoms (plants vs. animals) and across habitats (marine vs. terrestrial).ResultsPopulations at margins performed significantly worse than central populations and this trend was primarily driven by the low-latitude margin. Although the difference was of small magnitude, it was largely consistent across biological kingdoms and habitats. The differences in performance were positively related to the difference in average temperatures between populations during the period 1985–2016.Major conclusionsThe observed asymmetry in marginal population performance confirms predictions about the effects of global climate change. It indicates that changes in demographic rates in marginal populations, despite extensive short-term variation, can serve as early-warning signals of impending range shifts.
Molecular Biology Information Service: An innovative medical library-based bioinformatics support service for biomedical researchers
Authors: Chattopadhyay Ansuman , L. Iwema Carrie , A. Epstein Barbara , V. Lee Adrian , S. Levine Arthur 
Published: January 2019

AbstractBiomedical researchers are increasingly reliant on obtaining bioinformatics training in order to conduct their research. Here we present a model that academic institutions may follow to provide such training for their researchers, based on the Molecular Biology Information Service (MBIS) of the Health Sciences Library System, University of Pittsburgh. The MBIS runs a four-facet service with the following goals: (1) identify, procure, and implement commercially-licensed bioinformatics software, (2) teach hands-on workshops using bioinformatics tools to solve research questions, (3) provide in-person and email consultations on software/databases, and (4) maintain a web portal providing overall guidance on the access and use of bioinformatics resources and MBIS-created webtools. This paper describes these facets of MBIS activities from 2006-2018, including outcomes from a survey measuring attitudes of University of Pittsburgh researchers about MBIS service and performance.
TRANSFER LEARNING FROM NUCLEUS DETECTION TO CLASSIFICATION IN HISTOPATHOLOGY IMAGES
Authors: Yousefi Safoora , Nie Yao 
Published: January 2019

ABSTRACTDespite significant recent success, modern computer vision techniques such as Convolutional Neural Networks (CNNs) are expensive to apply to cell-level prediction problems in histopathology images due to difficulties in providing cell-level supervision. This work explores the transferability of features learned by an object detection CNN (Faster R-CNN) to nucleus classification in histopathology images. We detect nuclei in these images using class-agnostic models trained on small annotated patches, and use the CNN representations of detected nuclei to cluster and classify them. We show that with a small training dataset, the proposed pipeline can achieve superior nucleus detection and classification performance, and generalizes well to unseen stain types.
Functional potential of bacterial strains in the premature infant gut microbiome is associated with gestational age
Authors: Rahman Sumayah F. , Olm Matthew R. , Morowitz Michael J. , Banfield Jillian F. 
Published: January 2019

AbstractThe gut microbiota of premature and full-term infants have many known differences, but the extent to which the degree of prematurity influences the structure and functional potential of the microbiome has not been deeply explored. Here, we used genome-resolved metagenomics to address how gestational age impacts the premature infant gut microbiome. We found that gestational age is associated with species richness, with more premature infants having lower species richness; this effect lasts until the fourth week of life. NovelClostridiumspecies and strains related toStreptococcus salivariusandEnterococcus faecaliscolonize infants of different gestational ages, and the metabolic potential of these organisms can be distinguished. Thus, we conclude that the extent of prematurity, or directly linked factors, can be an important influence on the microbiome and its functions.
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage
Authors: Li Zhong-Rui , Li Jie , Cai Wenlong , Lai Jennifer Y. H. , McKinnie Shaun M. K. , Zhang Wei-Peng , Moore Bradley S. , Zhang Wenjun , Qian Pei-Yuan 
Published: January 2019

AbstractColibactin is an as-yet-uncharacterized human gut bacterial genotoxin, whose biosynthesis is linked toclbgenomic island that distributes widespread in pathogenic and commensal human enterobacteria. Colibactin-producing gut microbes promote colon tumor formation and enhance progression of colorectal cancer (CRC) via DNA double-strand breaks (DSBs)-induced cellular senescence and death; however, the chemical basis contributing to the pathogenesis at the molecular level remains elusive. Here we report the discovery and the mechanism of action of colibactin-645 as the highly sought final colibactin metabolite with a novel molecular scaffold. Colibactin-645 recapitulates its previously assumed genotoxicity and cytotoxicity, exhibiting a strong DNA DSBs activityin vitroand in human cell cultures via a unique copper-mediated oxidative mechanism. We also present a complete model for colibactin biosynthesis, revealing an unprecedented dual function of the aminomalonate-utilizing polyketide synthases. This work thus provides the first molecular basis for colibactin’s genotoxic activity and facilitates further mechanistic study of colibactin-related CRC incidence and prevention.
Changing agents of change in neoliberally framed organizations
Authors: Asirvatham Sheeba , Humphries Maria 
Published: January 2019

PurposeThis paper aims to invite reflection and action among scholars of gender in management to the shaping and meeting of commitments to universal justice.Design/methodology/approachIn total, 12 women employed as senior scholars in public universities in Aotearoa New Zealand were invited to discuss their career experiences. An observed disjuncture between radical feminist analyses of their career experiences and their liberal feminist responses to issues arising for them prompted reflection on a wider disjuncture in the shaping of justice wherever neoliberal directives prevail, generating this paper’s activist call to integrity between analyses and practice among scholars as agents of change.FindingsImplications drawn from the conversations with participants vindicated earlier critiques of diversity management under the conditions of neoliberalism when accommodating damaging social outcomes and systemic compliance is morally compromising.Originality/valueExploring accommodation of system preserving career strategies of scholars claiming commitment to justice is an evocative and original call to scholarly activism.
A cold call on work-based learning: a “live” group project for the strategic selling classroom
Authors: Lloyd Robert , Martin Michael J. , Hyatt James , Tritt Addison 
Published: January 2019

PurposeThe purpose of this paper is to describe a case study used in a strategic sales class that employs the use of work-based learning pedagogy to expose students to real-life cold calling experiences. This real-life cold calling experience involves students within the course building a target list of prospective students for a small liberal arts college. The students must then construct pre-call strategies, build rapport with prospective students and finally “close the deal” by having the prospective student visit campus.Design/methodology/approachThis paper begins by describing work-based learning as a unique pedagogical method and the importance of cold-calling skills in the context of workplace skills in demand. Theoretical foundations in Lichtenstein and Lyon’s (1996) entrepreneurial skillset is analyzed, as is the application of “live” group projects. The case is then described in detail and focuses on the project itself, the personal and group incentives used in the course of the project, and finally, a review of the learning outcomes and desired skillset outcomes for the class.FindingsThe case shows that students can learn and implement the behaviors, attitudes and practices that make professional cold-callers successful. The impact on the university can also be seen since real contributions were made to the recruiting efforts of the collegevis-à-vishigher matriculation numbers. The entrepreneurial skillsets and “live” group project literature is contextualized in light of the findings of the project. This research found that students engaged in varying levels of progress in their managerial, entrepreneurial, technical skillsets as well as levels of personal maturity. Finally, the authors provide guidance for future research to expound the findings of this project by testing the variables using quantitative methodologies.Originality/valueThe paper showcases an innovative pedagogic approach to exposing students to the best practices of cold-calling and allows them to exercise these tools real time as they make actual cold calls and work toward sales incentives. The focus on recruiting new students as customers of the college serves is not only active classroom learning, but it also serves mission-based outcomes to help the college achieve desired recruiting goals. This case study will provide a tool for small, liberal arts colleges to use which mobilizes faculty and students in the effort to recruit new students, in an environment where enrollment numbers are falling for this market sector in higher education.
Access and utilization of health services by migrant domestic helpers in Cyprus: the role of the employer
Authors: Kantaris Marios , Theodorou Mamas , Kaitelidou Daphne 
Published: January 2019

Purpose
The dominant role of the employer regarding the access and use of healthcare services by migrant domestic helpers (MDH) often has a negative impact on healthcare provision for migrants in Cyprus. Research relating to the perceptions of MDH employers remains scarce. The purpose of this paper is to investigate the role of employers on the access and use of healthcare services by their MDH.

Design/methodology/approach
Three studies were carried out using semi-structured interviews with MDH (n=13) and employers of MDH (n=12) and structured questionnaires with MDH (n=625). Content analysis for qualitative findings was carried out using QSR Nvivo 10 and for quantitative using Statistical Package for Social Sciences version 17.

Findings
Findings provide information about migrant health needs from different views leading to improved documentation via multiple triangulation. Employers play a key gatekeeping role but are not in position to provide sufficient information and guidance to their MDH. MDH reported a need for health services which was not met (18 percent), attributing this to their employers not granting them permission.

Originality/value
The role of the employer is critical and has an impact on the quality of care provided to this migrant group. The involvement of the employer in MDH health matters functions as a barrier. A significant gap exists between employers and MDH regarding the health needs of the latter.
Fatigue damage analysis of steel components subjected to earthquake loadings
Authors: Hou Chien-Yuan , Lee Yung-Feng , Peng Yen-Hao 
Published: January 2019

PurposeExamination of steel moment resisting frames after the 1994 Northridge earthquake showed fatigue cracks presented in the beam–column connections of the frames. These observations indicate that fatigue failure may occur in the steel components of building structures in an earthquake event. To apply the fatigue design approach using the Palmgren–Miner’s rule for steel components of the moment resisting frames requires the knowledge regarding the damage index value at fatigue failure. The purpose of this paper is to perform fatigue tests to give the first damage values of steel components subjected to real earthquake-induced loadings.Design/methodology/approachThe added-damping-and-stiffness steel plates which are used in building structures for earthquake mitigation were fabricated and tested by constant amplitude, SAC block and earthquake-induced loadings to failure. The earthquake loadings were obtained from the dynamic analysis of a steel frame with the mentioned plates. The load cycles of the SAC block and the calculated earthquake loadings were counted using the rainflow-counting method, and the damage index value of each specimen were calculated using the Palmgren–Miner’s rule.FindingsReverse stiffness obtained from cyclic load-displacement loops is a robust and consistent parameter that can be used for determining fatigue failure of tested components. The Palmgren–Miner’s damage values at failure, caused by earthquake loadings, are smaller than 1, and in addition, are also smaller than those obtained from the tests of the SAC block loading. The large-amplitude cycles in the earthquake loading produce large damage on the specimens, and intermediate range cycles also produce damage that should not be neglected in the fatigue analysis.Originality/valueToday’s building design code allows large plastic deformation to occur in steel frames during an earthquake. However, the pre-Northridge earthquake steel frames showed fatigue cracks without the expected substantial plastic deformation at beam flanges. Proposed solutions to this problem were the reduced beam section neglecting the existence of the cracks at beam–column connections. This study considered the fatigue phenomenon in steel frames and provided the first set of tested fatigue damage values for steel components subjected to realistic earthquake loadings, which offered a possible method of dealing with fatigue cracks in the steel components of a building structure.
Adoption of social networking sites for educational use
Authors: Owusu Godfred Matthew Yaw , Bekoe Rita Amoah , Otoo Dorothea Sekyiwa , Koli Akua Pokuaa Essah 
Published: January 2019

PurposeThe purpose of this paper is to examine the views of university students on social networking sites (SNSs) adoption for educational purposes and investigate the factors that motivate students to use SNSs for academic purposes.Design/methodology/approachA survey method of research was adopted and questionnaires were administered to the respondent group. A total of 522 valid responses from the University of Ghana Business School Students were used in the empirical analysis. Regression analysis was used to examine the relationship among the key constructs of the study.FindingsThe results of this study suggest that perceived usefulness, perceived ease of use, the existence of facilitating conditions and the purposes of SNSs are the key factors that motivate students to adopt SNSs for academic purposes. However, the influence of other people in society and the desire to be identified with social groups were found not to be important predictors of SNSs use by students for educational purposes.Research limitations/implicationsThe data examined in this study are based on sample responses from only one university, which may limit the extent of generalization of the findings.Originality/valueThis paper provides some useful insights into the key predictors of SNSs adoption for educational use by university students from the perspective of a developing country.
Examining attitudes on pay for low level workers: do consumers care?
Authors: Moran Nora 
Published: January 2019

PurposeThis paper examines whether decisions to improve pay for low-level employees lead to more positive attitudes toward firms, depending on firm’s service reputation.Design/methodologyFour experiments examine whether information on compensation decisions for employees affects consumer attitudes toward firms.FindingsResults show attitudes toward firms providing raises are more positive when firms are known for high quality (vs average) service. This occurs because individuals use information about firm reputation as a cue to make inferences about employees, and fairness of firm pay procedures. Moderators are introduced to show how these effects can be altered.Research limitations/implicationsDrawing from research on the representativeness bias, this work extends theories on justice and equity and contributes to the literature on corporate social responsibility.Practical implicationsThis research provides firms with insight on how to promote their efforts to improve employees’ financial welfare.Social implicationsFindings provide guidance on how to increase public support of initiatives to improve financial well-being for low-wage workers.Originality/valueThis research is the first to examine how specific firm factors affect reception of initiatives to improve employee financial welfare and to delineate the process.