bluuebunny/crossref_metadata_2025_split huggingface dataset:
AÇIKTA KONUMLANAN DERİN SU LİMANLARININ HUKUKÎ STATÜSÜ: GDANSK KÖRFEZİNDE İNŞA EDİLECEK DERİN SU LİMANINA DAİR
Authors: ÇAMYAMAÇ Anıl 
Published: May 2018

1970’lerde
petrol ihtiyacı ve sıkıntısı ciddî bir çalkantıya sebep olmuştur. Bu iklim
altında, Batılı devletlere petrolün verimli biçimde taşınması gereği büyük
tankerlerin inşasını da beraberinde getirmiştir. Fakat, bu büyük taşıtların
limanlarda ağırlanmasına dair yeni bir sorun da ortaya çıkmıştır. O günlerde,
sanayileşmiş devletlerde bu büyüklükteki taşıtları misafir edebilecek
uygunlukta bir liman bulunmamaktaydı. Böylece, denizlerin bu devasa taşıtlarını
misafir edecek derin su limanı projeleri geliştirildi. Günümüzde, bu trend
devam etmekte ve sadece tankerlerle de sınırlı olmamaktadır; misal, sayılan bu
nedenlerden ötürü devasa ebatlarda konteyner gemileri inşa edilmektedir. Derin
su limanı inşaatı ihtiyacı günümüzde hiç olmadığı kadar önemlidir. Bu kısa
makalede, Gdansk’ta inşa edilecek derin su limanı özelinde kıyıdan açıkta
konumlanan derin su limanlarının hukukî statüsü ele alınacaktır. Böylelikle, bu
makale şu şekilde oluşturulmuştur. Sırasıyla limanların, demiryerlerinin ve
derin su limanlarının tanımlanması; derin su limanlarının önemi; plânlanan ve halîhazırda inşa edilmiş derin su
limanları; uluslararası deniz hukukunda derin su limanlarının hukukî statüsü; gdansk
Körfezinde inşa edilecek derin su limanının kısa bir değerlendirmesi ve sonuç.
Low cost sustainable materials for grey water reclamation
Authors: James Dalrene Teresa Keerthika , Ifelebuegu Augustine Osamor 
Published: May 2018

Abstract
Grey water reclamation is a sustainable solution for managing water shortages. However, grey water contains high levels of detergents, particularly surfactants, which alongside other chemical constituents can pose a serious risk to human health and the environment. Biological treatments are not effective in the treatment of grey water since the detergents inhibit the activities of microorganisms. Chemical treatment options have an impact on public perception and could be cost prohibitive for domestic and small scale reuse applications. In this paper, we review the characterization of the constituents of grey water and the application of various low cost sustainable materials such as zeolite, activated carbon, mussel shells, tyre granules, fly ash, ground granulated blast furnace slag and silica gel for the treatment and removal of detergent characteristics.
Recent Insights into the Development of Preclinical Trastuzumab- Resistant HER2+ Breast Cancer Models
Authors: Gonzalez-Alonso Paula , Cristobal Ion , Zazo Sandra , Martin-Aparicio Ester , Chamizo Cristina , Madoz-Gurpide Juan , Rovira Ana , Eroles Pilar , Lluch Ana , Albanell Joan , Rojo Federico 
Published: May 2018

Background:
Overexpression and amplification of the human epidermal growth
factor receptor 2 (HER2) occur in 20% of total breast carcinomas. HER2-overexpression is
implicated in disease initiation and progression and associated with poor prognosis. Trastuzumab,
a humanized monoclonal antibody, is the standard HER2-targeted therapy for early
and metastatic HER2-amplified breast cancer patients. Trastuzumab has significantly increased
clinical benefit in HER2+ metastatic and adjuvant settings; however, it is not effective
for many patients due to primary or acquired resistance to the drug. During the last decade,
many studies have revealed a number of novel molecular traits of HER2+ breast cancer, allowing
us to uncover the molecular mechanisms involved in trastuzumab resistance and develop
strategies to overcome resistance to therapy.

Objective:
In this review, we comprehensively addressed the current achievements in preclinical
studies; we discussed molecular mechanisms of acquired trastuzumab resistance in
HER2+ breast cancer models and potential therapeutic approaches based on the molecular
features for HER2+ breast cancer.

Conclusion:
Enhanced understanding of the molecular profiles in HER2+ breast cancer may
lead to the identification of novel biomarkers for the development of diagnostic approaches
and improvement of therapeutic targets for the prevention and treatment of trastuzumab resistant
HER2+ breast cancer.
Design and Synthesis of Novel Thioethers Derived from 1,5-Diphenyl-6- thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as Antiangiogenic Agents
Authors: Malki Ahmed , Issa Doaa A.E , Elbayaa Rasha Y. , Ashour Hayam M.A. 
Published: May 2018

Background:
In attempts to discover new antiangiogenic entities, a novel series of
thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered
and designed.
</P><P>
Methods: Virtual screening was carried out through docking of the compounds into the vascular
endothelial growth factor and matrix metalloproteinase-9 binding sites. Molecular docking studies
were performed using Lamarckian Genetic Algorithm. Compounds possessing lowest ligandprotein
pairwise interaction energies were synthesized and screened for their antiproliferative activities
against five cancer cell lines namely MHCC97H (liver), MDA-MB 231 (Breast), Colo205 (Colon),
A549 (lung), A498 (kidney) and IC50 values were determined for the most potent compounds.
Additionally, they were tested for their antiangiogenic activities by testing their ability to inhibit
Human Umbilical Vein Endothelial Cell (HUVEC), cord formation and migration in response to
chemoattractant.

Results:
Three compounds 2a, 2b and 5b showed significant antiangiogenic activities. The allyl
thioether 2b was the most active with chemotaxis activity data nearly comparable to that of the positive
control, TNP-470. Additionally, 2a, 2b and 5b, contrary to TNP-470, interfered with the migration
of HUVECs in response to vascular endothelial growth factor rather than endothelial cells proliferation
or cord formation. Compounds 2a, 2b and 5b were also investigated for their inhibitory
effects on MMPs to investigate the relationship between their angiogenic activity and MMPs. Results
revealed that compound 2b was the most effective MMP-9 inhibitor in this series. Additionally,
compound 2b reduced the expression levels of VEGF and pERK1/2.

Conclusion:
Our results suggest that compound 2b is considered as a promising antiangiogenic
agent by targeting VEGF and MMP-9.
Genetics and Epigenetics Mechanism in the Pathogenesis of Behçet’s Disease
Authors: Muhammad Jibran Sualeh , Ishaq Muhammad , Ahmed Khalid 
Published: May 2018

Background:Behçet’s Disease (BD) is characterized by numerous systemic manifestations and is known for its ability to affect both, arteries and the veins. However, the etiology of BD is only partially understood, and previous studies have demonstrated a role for genetic and epigenetic factors that contribute to disease pathophysiology. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in activating lymphocyte proliferation, maturation, and differentiation in BD. This article presents a review of the published literature mainly from the last 20 years. The topics of main concern were the role of genetic and epigenetic factors as contributing factors in disease pathophysiology.Result and Conclusion:The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic” or “epigenetic” to search the PubMed database. All the relevant studies identified were included and are described according to the aforementioned subheadings.
Voltammetric Biosensor Based on Nitrogen-doped Ordered Mesoporous Carbon for Detection of Organophosphorus Pesticides in Vegetables
Authors: Long Beiqing , Tang Lin , Peng Bo , Zeng Guangming , Zhou Yaoyu , Mo Dan , Fang Siyuan , Ouyang Xilian , Yu Jiangfang 
Published: May 2018

Background:
Pesticides residues in agricultural products have posed a serious threat to food
safety and human health, so it is necessary to develop a rapid and accurate method to detect pesticide in
the environment. N-OMC with excellent electroconductivity, high biocompatibility and the functional
amino group that can be covalently attached to the enzyme can be applied to construct a sensitive and
stable acetylcholinesterase biosensor for rapid and accurate detection of organophosphorus pesticides
with the help of L-cysteine self-assembled monolayer and AuNPs.

Methods:
Transmission electron microscopy, scanning electron microscopy, Fourier transform infrared
spectroscopy and nitrogen adsorption measurements are used to characterize materials. Electrochemical
impedance spectroscopy and cyclic voltammetry are used to study the surface features of modified
electrodes. Differential pulse voltammetric is used to measure the peak current of modified electrodes.
GC-MS is applied to verify the reliability of the prepared biosensor for organophosphorus pesticides
detection.

Results:
N-OMC was synthesized and applied to constructed stable and sensitive acetylcholinesterase
biosensors. The combination of N-OMC, L-cysteine self-assembled monolayer and AuNPs to modify
the electrode surface has greatly improved the conductivity of biosensor and provided a stable platform
for acetylcholinesterase immobilization. The linear detection range of paraoxon was from 3 to 24 nM
with a lower detection limit of 0.02 nM.

Conclusion:
The biosensor exhibited satisfactory reproducibility, repeatability and stability, and was
successfully employed to determine the paraoxon in vegetables as well as tap water samples, providing
a promising tool for rapid and sensitive detection of organophosphorus pesticides in agricultural products.
Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives
Authors: Yang Canyu , Li Ji , Yao Yanyun , Qing Chen , Shen Baochun 
Published: May 2018

Background:Cinacalcet is one of the second-generation calcimimetics which consists of a chiral center. The pharmacological effect of R-cinacalcet is 1000 times greater than that of the Scinacalcet. As mentioned in many literatures, 1-(1-naphthyl)ethylamine is used as the starting material for the synthesis of cinacalcet. The absolute structure of cinacalcet is influenced by the starting materials.Methods:We present the chiral separation of cinacalcet and its starting material, 1-(1-naphthyl) ethylamine along with one of its intermediates, N-(1-(naphthalen-1-yl) ethyl)-3- (3-(trifluoromethyl) phenyl) propanamide by high-performance liquid chromatography with chiral stationary phase and chiral mobile phase additives.Results:On vancomycin and cellulose tri 3,5-dimethylphenylcarbamate) chiral stationary phase, cinacalcet and 1-(1-naphthyl)ethylamine achieved enantioseparation under normal phase with addition of triethylamine additives, respectively. Meanwhile, 1-(1-naphthyl)ethylamine and N-(1-(naphthalen-1- yl)ethyl)-3-(3-(trifluoromethyl) phenyl) propanamide achieved enantioseparation on 1-napthalene vancomycin chiral stationary phase using D-tartaric acid, diethyl L-tartrate and diethyl D-tartrate as chiral mobile phase additives.Conclusion:The chiral recognition in our experiment was based on the hydrogen-bonding, dipoledipole and π-π interactions among the solutes, chiral stationary phases and chiral mobile phase additives. In addition, the space adaptability of chiral stationary phases also affected the separation efficacy.
Performance Evaluation of Mechanical Power Amplifier for Various Belt Materials
Authors: Gawande S. H. 
Published: May 2018

Background:
In many applications, it is required to control a large output load using a relatively low control force. To satisfy such purposes, a device like mechanical power amplifier can be used which generally gives a very fast response. As per the requirement of the system, power can be instantaneously available from continuously rotating drums of the mechanical power amplifier.

Objective:
This paper focuses on the computation of amplification factor of the mechanical power amplifier for different rope materials like leather, woven cotton and steel rope.

Method:
In this study the experimental analysis is performed. A capstan is a simple mechanical amplifier-rope wound on a motor-driven drum. The drums rotate continuously but communicate torque only when the input shaft is rotated to constricts drum A as shown in Fig. (3).

Results:
From the experimental analysis, it endorses that when the optimal number of turns tend to two, power amplification factor is to be 2.23 for leather contact, 1.867 for woven cotton contact, 1.32 for steel contact of rope.

Conclusion:
From the experimental analysis, it is seen that power amplification is higher for leather as compared to woven cotton and steel. The results are remarkably consistent with experimental measurements including favorable calculation of amplification factor.
An Overview of Paris polyphylla, a Highly Vulnerable Medicinal Herb of Eastern Himalayan Region for Sustainable Exploitation
Authors: Puwein Arcadius , Thomas Shiny C. 
Published: May 2018

Background:
Paris polyphylla has been traditionally used in China, India and Nepal to
relieve various ailments such as antidote for snake bites, insect poison, relieving wounds, sore
throat, etc. P. polyphylla like many plants in nature contains numerous potential bioactive compounds.
Such bioactive compounds of the herb that have significant biological activities such as anticancer, antibacterial,
antifungal and antiviral need to be validated and augmented with many assays.

Objective:
The objective of this paper is to compile the major research works of the herb and updates
information on its developments and approaches that have been rapidly taking place in recent
years, so that further novel research can be envisaged.

Methods:
The published reviews act as the first catalyst and initiator to delve on the studies done so
far about this medicinal herb. The research about the plant such as classification, micropropagation,
phytochemisty, and bioactivity was investigated from papers that were reported from index journals

Results:
New compounds such as paristenosides A and B are being added to the existing known
compounds. There are new high-throughput approaches in the classification of the plant and micropropagation.
The traditional uses of the herb are being validated through different bioactivity assays.

Conclusion:
The continuous research that is being carried out on this herb implies that the depth of
knowledge about the plant is gradually consolidated and the mechanism of the bioactive compounds
derived is slowly comprehended.
Model of Trust Monitoring and Updating Based on Dynamic Weighted Allocation
Authors: Hu Bin , Wu Yuemin , Sun Min , Bang Liu Zheng , Zhang Lin , Yan Jia-Xing , Huang Shan , Zhu Shu-Xin 
Published: May 2018

Backgrounds: In order to guarantee safe and efficient operation interaction in open network environment, a new dynamic trust monitoring and updating model based on behavior context is proposed in this paper.Methods:Setting four behavior attributes such as security, availability, reliability and performance. Then utilizing the fuzzy clustering and information entropy mathematical methods to carry out the effective synthesis on such attributes.Conclusion:The effectiveness and efficiency of the schema are verified by simulation.
Pemanfaatan Teknologi Digital dalam Proses Alih Media Arsip Statis
Authors: Laksono Ridho 
Published: May 2018

AbstractThis study aims to describe the use of digital technology in the transfer of media. Discussion includes the process of media transfer (digitization), supporting facilities and infrastructure, and the challenges that arise in this process.The methods used in this study are literature study and participant observation. Through the above method, there are several aspects that need to be considered in the transfer of textual archives. The first is supporting facilities, archive and archivist conditions. Second, the stages of digitization process include preparation, scanning, editing, and storing textual archives in the digital file format.Based on the analysis of the context of the use of digital technology in supporting the process of digitization, some hypotheses are drawn. First is the importance of maintaining the archive since it is still active, this is intended to facilitate the processing of the archives. Second, the problem of authenticity of the archive should be the concern of the creator and user. This is important to be discussed further because one of the reasons for preservation of static archives is the legal aspect it has. Third, the process of digitization must refer to Undang – Undang Nomer 43 Tahun 2009 Tentang Kearsipan and Peraturan Pemerintah Nomer 28 Tahun 2012 Tentang Pelaksanaan Undang – Undang Nomer 43 Tahun 2009 Tentang Kearsipan. This reference relating to archive processing that should refer to the principle of the original order and the provenance.Keywords: Archives, digitization IntisariKajian ini bertujuan untuk mendeskripsikan pemanfaatan teknologi digital dalam alih media arsip statis. Pembahasan termasuk proses alih media, sarana dan prasarana pendukungnya, serta tantangan yang muncul dalam proses ini. Metode yang digunakan dalam kajian ini adalah studi pustaka dan observasi partisipatif. Melalui metode di atas didapatkan informasi mengenai beberapa aspek yang perlu dipertimbangkakn dalam alih media arsip statis. Pertama adalah sarana prasarana pendukung, kondisi arsip dan arsiparis. Kedua, tahapan alih media meliputi persiapan, scanning, editing, dan menyimpan arsip statis tekstual dalam format digital file.Berdasarkan analisis terkait konteks pemanfaatan teknologi digital dalam mendukung proses alih media arsip statis, ditarik beberapa hipotesis. Pertama adalah pentingnya pemeliharaan arsip sejak masih berstatus dinamis aktif, hal ini dimaksudkan untuk memudahkan pengolahan. Kedua, permasalahan keotentikan arsip harus menjadi perhatian pihak-pihak yang bersangkutan. Hal ini penting untuk dibahas lebih lanjut sebab salah satu alasan preservasi arsip statis adalah aspek legal yang dimilikinya. Ketiga, proses alih media tetap harus mengacu pada Undang – Undang Nomer 43 Tahun 2009 Tentang Kearsipan dan Peraturan Pemerintah Nomer 28 Tahun 2012 Tentang Pelaksanaan Undang – Undang Nomer 43 Tahun 2009 Tentang Kearsipan. Acuan ini berkaitan dengan pengolahan arsip harus merujuk pada prinsip aturan asli (original order) dan prinsip asal-usul (provenance).Kata kunci: Arsip Statis, alih media.
A SENSIBILIDADE SECULAR DA POLÍTICA BRASILEIRA
Authors: Dullo Eduardo , Quintanilha Rafael 
Published: May 2018

A religião vem se consolidando como um tema de controvérsia e manifestação nas eleições brasileiras das últimas décadas. Apesar disso, os pesquisadores têm se mantido restritos aos agentes religiosos, ignorando a sua contraparte relacional, isto é, os agentes que questionam ou rejeitam a presença religiosa na política eleitoral. Este artigo pretende discutir as críticas feitas ao pertencimento religioso da candidata Marina Silva, sobretudo pela via do humor, como uma maneira de acesso à sensibilidade secular da política brasileira contemporânea. Uma das conclusões é a de que o conflito entre distintas comunidades morais pode ser melhor compreendido por meio do conceito de cismogênese, proposto por Bateson, e que esse conflito
mantém ativa a tensão dinâmica entre o religioso e o secular.
A REINVENÇÃO DO CONSERVADORISMO: OS EVANGÉLICOS E AS ELEIÇÕES FEDERAIS DE 2014
Authors: Tadvald Marcelo Tadvald 
Published: May 2018

Analiso neste trabalho a atuação da Frente Parlamentar Evangélica,
conhecida popularmente como bancada evangélica, a partir do resgate de alguns dados históricos e da atuação desta bancada na legislatura passada para avaliar a campanha eleitoral de 2014 e a sua composição atual, tendo em vista resgatar alguns de seus paradigmas e projetar a sua atuação na próxima legislatura do Parlamento brasileiro.
PENTECOSTAIS E MOVIMENTO LGBT NAS ELEIÇÕES PRESIDENCIAIS DE 2014
Authors: Trevisan Janine 
Published: May 2018

O artigo realiza uma análise da presença pentecostal nas eleições
presidenciais de 2014, especialmente no que se refere ao confronto estabelecido com o movimento LGBT. O artigo está dividido em duas partes. Na primeira, para compreender o processo que repercutiu em 2014, analiso as ações do governo Lula (2003-2010) e do primeiro governo Dilma (2011-2014) para atender as demandas tanto do segmento evangélico quanto do movimento LGBT, buscando destacar o processo político pelo qual lideranças evangélicas ganharam espaço e força política a ponto de confrontar demandas de movimentos sociais, especialmente feministas e LGBT. A segunda parte analisa o primeiro turno das eleições presidenciais de 2014, explorando o caso da controversa alteração no programa da candidata Marina Silva (PSB) sobre as políticas para o segmento LGBT. O caso foi mblemático para demonstrar o crescente embate político entre lideranças pentecostais e lideranças em defesa dos direitos LGBT no Brasil.
ASSISTÊNCIA SOCIAL ESPÍRITA E CULTURA DA FILANTROPIA: APROXIMAÇÕES E DISTINÇÕES ENTRE CARIDADE E AÇÃO CIDADÃ
Authors: Decker Norberto 
Published: May 2018

Por meio de trabalho de campo em duas instituições espíritas de Curitiba, Brasil, que desenvolvem atividades de assistência social, identifico os modos de agir, de pensar e de crer das instituições espíritas vinculadas à área de ação social com o objetivo de apreender a perspectiva dos diferentes agentes sociais envolvidos em atividades definidas como prática da caridade e da assistência social. Aponta a etnografia para um rumo que a ação social espírita vem tomando nas últimas duas décadas ao se apropriar do conceito de cidadania e relacioná-lo ao de caridade, na busca de se produzir novas formas de atuação social do Espiritismo, tais como a inserção deste em fóruns organizados pela sociedade civil e em conselhos do Estado. Atesta-se, assim, a ocorrência de uma reavaliação das funções sociais da religião
junto ao Estado na área das políticas sociais de combate à pobreza, indicando valores religiosos como uma das motivações de participação cidadã.
O CULTO ECÚMENO-CIENTÍFICO: ANÁLISE DO CULTO ECUMÊNICO EM HOMENAGEM AOS DOADORES DE CORPOS
Authors: Freire de Andrade Neves Marcos 
Published: May 2018

Este artigo tem por objetivo fazer uma análise ritual do Culto Ecumênico
em Homenagem aos Doadores de Corpos, promovido por uma universidade na cidade de Porto Alegre. Um Culto ecumênico realizado no interior de uma capela universitária, conduzido por profissionais da saúde vestidos com jalecos brancos, e performado por discursos de progresso científico. A partir da descrição, propõem-se questionamentos acerca da noção de sagrado e sua relação com o cadáver humano, bem como concernentes à interação entre religião e ciência.
“O POVO CATÓLICO TAMBÉM TEM AXÉ”: A ESTÉTICA POP BRASILEIRA E A INCULTURAÇÃO CARISMÁTICA
Authors: De Sousa Bonfim Evandro 
Published: May 2018

O artigo busca mostrar como artistas ligados à Renovação Carismática
Católica lidam com o tema da inculturação, buscando nas fontes da cultura de massa brasileira elementos para a composição de uma estética religiosa pop centrada na transmissão do Espírito Santo através das mídias. O exemplo tratado é o da cantora de axé cristão Jake, que, através de imagens, letras, acompanhamento musical e adoção da fala regional nordestina, se transforma na figura da baiana, procurando
assim produzir uma mensagem cristã brasileira e promover a diversificação interna do movimento carismático.