bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of different irrigants on substance P and IL‐8 expression for single visit root canal treatment in acute irreversible pulpitis
Authors: Evangelin J. , Sherwood I. Anand , Abbott Paul V. , Uthandakalaipandian Ramesh , Velu Vijay 
Published: July 2019

AbstractThe aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL‐8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL‐8 were done using ELISA test. Post‐operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL‐8 values. Dexamethasone irrigation was more effective in controlling post‐operative pain.
Evaluation of bevelled needle tip deformation with Dental Inferior Alveolar Nerve blocks
Authors: Skapetis Tony , Doan‐Tran Phuong Diem , Hossain Nibir M. 
Published: July 2019

AbstractThe study aimed to investigate whether any correlation existed between bevel orientation and needle tip deformation following the administration of a standard inferior alveolar nerve block (IANB) technique during patient treatment. Ninety‐three needles of a single brand were collected from a group of eleven similarly trained Australian dentists’ following either single or dual insertion and bone contact. Specimens were examined under scanning electron microscopy at 500x, and both the direction of deformation (either towards or away from lumen) and the extent of deformation were calculated using image processing software. Results showed no correlation between bevel orientation and either the direction (P = 0.8787) or degree (P = 0.0752) of deformation. Significance was demonstrated, regardless of bevel orientation, following multiple needle use with respect to extent of needle tip deformation (P < 0.0001). A clinical recommendation can be made that the dental needle should be routinely replaced when subsequent injections are required during the delivery of a typical IANB.
Weed seed availability, carabid intraspecific interference and their interaction drive weed seed consumption by carabid beetles
Authors: Carbonne Benjamin , Bohan David A. , Charalabidis Alice , Petit Sandrine 
Published: July 2019

Abstract
Carabid beetles may play a role in the regulation of arable weeds, when seed predation is directly density‐dependent and consumption increases more than proportionally with seed density.
We quantified the effect of seed and carabid density on consumption by two carabid species (Poecilus cupreus and Harpalus affinis) of the weed species Taraxacum officinale and Viola arvensis. For each pairing of carabid and weed species, we quantified per capita seed mortality (PCSM) over 72 h under combinations of low and high densities of carabids and seeds, aiming to assess whether per capita consumption increased more or less than proportionally with seed density.
We tested three hypotheses: (i) PCSM is constant as seed availability increases; (ii) for a fixed seed density, PCSM decreases with increasing numbers of carabid conspecifics; and (iii) the response of PCSM changes with the interaction between seed and carabid density.
Without intraspecific competition, we detected a seed density‐independent predation effect, which became inverse density‐dependent over time. At similar seed densities, the presence of conspecific carabids did not affect PCSM, although it led to a faster shift towards inverse density dependence in T. officinale.
The findings of the present study suggest that a sufficiently large carabid numerical response might lead to direct predation density‐dependence.
Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery
Authors: Dudi‐Venkata Nagendra N. , Kroon Hidde M. , Bedrikovetski Sergei , Moore James W. , Sammour Tarik 
Published: July 2019

BackgroundPost‐operative ileus (POI) and delayed return of gastrointestinal (GI) function are common complications after colorectal surgery. There is a lack of uniformity in enhanced recovery protocols (ERPs) with regards to interventions used to target these complications. This systematic review aims to categorize and summarize management recommendations available from published ERPs.MethodsA systematic search of Ovid MEDLINE, Embase, Cochrane Library and PubMed databases was performed from January 1990 to May 2018. All studies publishing enhanced recovery or fast‐track or multimodal pathway protocols for colorectal surgery in their full‐text were included. Data on interventions aimed at reducing the duration of POI were extracted, as well as references quoted to support specific interventions.ResultsOf 481 manuscripts screened, 37 published ERPs were identified from 37 studies (18 cohort, seven historical‐control, five guidelines, four randomized controlled trials, one randomized controlled trial protocol, one case series and one narrative review). The most commonly recommended interventions were magnesium‐based laxatives (18 of 37, 48.6%), chewing gum (13 of 37, 35.1%), Alvimopan (6 of 37, 16.2%), lactulose (4 of 37, 10.8%), neostigmine (2 of 37, 5.4%) and bisacodyl (2 of 37, 5.4%). Geographical trends were noted for the various interventions, but high‐quality evidence was only referenced to support the use of Alvimopan.ConclusionERP recommendations specific to interventions targeting POI and return of GI function are varied. While laxatives are the most commonly recommended intervention, there is only weak evidence reported to support this practice.
MicroRNA‐128/homeobox B8 axis regulates ovarian cancer cell progression
Authors: Li Rui , Gong Lingling , Li Pin , Wang Jing , Bi Liangliang 
Published: July 2019

AbstractMicroRNA‐128 (miR‐128) has been found to be dysregulated and might function as a tumour suppressor in various cancers, including ovarian cancer. However, the underlying mechanism of miR‐128 in ovarian cancer has not been fully understood. The miR‐128 and homeobox B8 (HOXB8) levels in clinical samples and cultured cell lines were measured using qRT‐PCR and/or Western blot analysis. Cell proliferation was assessed using Cell Counting Kit‐8 assay. Cell apoptosis was determined using flow cytometry. The association between miR‐128 and HOXB8 was confirmed using dual‐luciferase reporter assay. Results showed that decreased miR‐128 expression and increased HOXB8 expression were observed in ovarian cancer tissues and cell lines. Transfection with miR‐128 mimics suppressed the cell proliferation and enhanced paclitaxel sensitivity in ovarian cancer cell lines. miR‐128 directly targeted HOXB8 in ovarian cancer cell lines. Knockdown of HOXB8 abolished the effects of miR‐128 inhibitor on ovarian cancer cell proliferation and paclitaxel sensitivity. Summarily, miR‐128 displayed a tumour suppressor role in ovarian cancer via targeting HOXB8. It is supposed that miR‐128 might be effective for targeting therapy for ovarian cancer.
The influence of narrative competence on mental state talk in kindergarten and primary school children
Authors: Tarchi Christian , Bigozzi Lucia , Pinto Giuliana 
Published: July 2019

This study investigates the relationships between narrative competence and mental state talk at different age levels. Specifically, we explored whether a higher level of structure in narratives is associated with children's mental state talk, and whether this effect is moderated by age (kindergarten, lower and upper primary school). The participants in the study were 172 Italian children. The children were asked to tell a story and their productions were coded for narrative structural level and mental state talk. Data showed higher levels of narrative structure were associated with a higher frequency of emotional, cognitive, moral, and socio‐relational terms. Results of the present study contributed to improve our understanding about how mental state talk and narrative competence are associated in different ways at different ages. This result suggests that children may develop in the ability to coordinate mental state talk and narrative structure as an effect of both, age and schooling.
Statement of contribution

What is already known on this subject?

Theory of mind and language are interconnected.

Theory of mind can be assessed through mental state talk.

Mental state talk is elicited through narrative tasks.

What does this study add?

Narrative competence is associated with mental state talk.

The first years of primary school seem to represent an important transition in children's development in narrative competence and MST.

Children may develop in the ability to coordinate mental state talk and narrative structure as an effect of both, age and schooling.
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection
Authors: Rosli Sarah , Kirby Francis J. , Lawlor Kate E. , Rainczuk Kate , Drummond Grant R. , Mansell Ashley , Tate Michelle D. 
Published: July 2019

Background and PurposeSevere influenza A virus (IAV) infections are associated with damaging hyperinflammation that can be fatal. There is an urgent need to identify new therapeutic agents to treat severe and pathogenic IAV infections. Repurposing of drugs with an existing and studied pharmacokinetic and safety profile is a highly attractive potential strategy. We have previously demonstrated that the NLRP3 inflammasome plays time‐dependent roles during severe IAV infection with early protective responses and later dysregulation leading to excessive inflammation, contributing to disease severity.Experimental ApproachWe tested two existing drugs, probenecid and AZ11645373, to target P2X7 receptor signalling and dampen NLRP3 inflammasome responses during severe IAV infection. In vitro, the drugs were assessed for their ability to limit NLRP3 inflammasome‐dependent IL‐1β secretion in macrophage cultures. In vivo, their effects were assessed on hyperinflammation and disease during severe IAV infection in C57BL/6 mice.Key ResultsTreatment of macrophages with probenecid or AZ11645373 in vitro diminished NLRP3 inflammasome‐dependent IL‐1β secretion. Intranasal therapeutic treatment of mice displaying severe influenza disease with probenecid or AZ11645373 reduced pro‐inflammatory cytokine production, cellular infiltrates in the lung, and provided protection against disease. Importantly, these drugs could be administered at either early or late stage of disease and provide therapeutic efficacy.Conclusions and ImplicationsOur study demonstrates that the anti‐inflammatory drugs probenecid and AZ11645373, which have documented pharmacokinetics and safety profiles in humans, are effective at dampening hyperinflammation and severe influenza disease providing potentially new therapeutic strategies for treating severe or pathogenic IAV infections.
Screen time and childhood overweight/obesity: A systematic review and meta‐analysis
Authors: Fang Kehong , Mu Min , Liu Kai , He Yuna 
Published: July 2019

AbstractBackgroundControlling childhood overweight/obesity would help early prevention on children from getting chronic noncommunicable diseases, exposing to screen for long periods may increase the risk of overweight/obesity due to lack of physical activity and tend to intake too much energy, and the relationship between screen time and overweight/obesity is inconsistent. Thus, the object of the present study was to estimate the relationship between screen time and overweight/obesity in children (<18 years) by systematically review prevalence studies.MethodsWe collected data from relevant studies published up to May 2019 using predefined inclusion/exclusion criteria. And all the literatures were searched in PubMed, ScienceDirect, Embase, and Web of Science.ResultsA total of 16 studies met the criteria and were included in the meta‐analysis. When compared with the screen time <2 hr/day, an increased overweight/obesity risk among children was shown in the screen time ≥2 hr/day (OR = 1.67; 95% CI [1.48, 1.88], P < .0001). The subgroup analysis showed a positive association between the different types of screen time and overweight/obesity among children.ConclusionBased on our study, increasing screen time could be a risk factor for being overweight/obesity in children and adolescents.
Plant domestication disrupts biodiversity effects across major crop types
Authors: Chacón‐Labella Julia , García Palacios Pablo , Matesanz Silvia , Schöb Christian , Milla Rubén 
Published: July 2019

AbstractPlant diversity fosters productivity in natural ecosystems. Biodiversity effects might increase agricultural yields at no cost in additional inputs. However, the effects of diversity on crop assemblages are inconsistent, probably because crops and wild plants differ in a range of traits relevant to plant–plant interactions. We tested whether domestication has changed the potential of crop mixtures to over‐yield by comparing the performance and traits of major crop species and those of their wild progenitors under varying levels of diversity. We found stronger biodiversity effects in mixtures of wild progenitors, due to larger selection effects. Variation in selection effects was partly explained by within‐mixture differences in leaf size. Our results indicate that domestication might disrupt the ability of crops to benefit from diverse neighbourhoods via reduced trait variance. These results highlight potential limitations of current crop mixtures to over‐yield and the potential of breeding to re‐establish variance and increase mixture performance.
The historian beneath the skin: Embodiment as methodology in colonial India
Authors: Topdar Sudipa 
Published: July 2019

AbstractWhile the pioneering historians of medicine and sexuality in colonial India have left us a rich scholarly legacy, this article contributes to the history of the body by examining recent historiographical trends outside these realms. I provoke and ask: in what other imaginative ways can we understand our body, its meanings, and its engagement with culture and self. I use embodiment as an analytical category and pedagogical device that offers promising possibilities to access wider social, economic, and epistemological shifts in history. When intersected with other critical concepts such as gender, race, nation, class, caste, and sexuality, embodiment becomes a bridge to the past for understanding how key moments were experienced and lived. Embodiment provides a point of convergence at which both the discursive body and its experiences are given equal attention in order to understand histories. I begin this article with an overview of foundational moments in the historiography of embodiment as a category of historical analysis. Subsequently, I explore three main axes of historiographical pursuits keeping embodiment as the pivot: first, social inscriptions on the body; second, the performance of gender; and third, embodiment as experience.
lilacs search strategy for systematic reviews of diagnostic test accuracy studies
Authors: Pereira Rogério Aparecido , Puga Maria Eduarda dos Santos , Atallah Álvaro Nagib , Macedo Elizeu Coutinho , Macedo Cristiane Rufino 
Published: July 2019

AbstractBackgroundThere are few publications on search strategies to identify diagnostic test accuracy (DTA) studies in lilacs.ObjectiveTo translate and customise medline search strategies for use in lilacs and assess their retrieval of studies in Cochrane DTA systematic reviews.MethodWe developed a six‐step process to translate and customise medline search strategies for use in lilacs (iAHx interface). We identified medline search strategies of published Cochrane DTA reviews, translated/customised them for use in lilacs, ran searches in lilacs and compared the retrieval results of our translated search strategy versus the one used in the published reviews.ResultsOur lilacs search strategies translated/customised from the medline strategies retrieved studies in 70 Cochrane DTA reviews. Only 29 of these reviews stated that they had searched the lilacs database and 21 published their lilacs search strategies. Few had used the lilacs database search tools, none exploded the subject headings, and 86% used only English terms.ConclusionTranslating and tailoring a medline search strategy for the lilacs database resulted in the retrieval of DTA studies that would have been missed otherwise.
Increasing shelf life of strawberries (Fragaria ssp) by using a banana starch‐chitosan‐Aloe vera gel composite edible coating
Authors: Pinzon Magda I. , Sanchez Leidy T. , Garcia Omar R. , Gutierrez Ramón , Luna Julio C. , Villa Cristian C. 
Published: July 2019

SummaryStrawberries are among the most consumed fruits in the world, however, they are highly susceptible to both microbial and fungal contamination during storage. In this study, we used composite films made from banana starch‐chitosan and Aloe vera gel (AV gel) at different AV gel concentrations. Our results show that AV gel inclusion can significantly reduce fungal decay, increasing strawberries shelf life up to 15 day of storage at the highest AV gel concentration (20%), while maintaining their physicochemical properties, such as colour and firmness. Weight loss was reduced 5% with respect of the uncoated fruit. Our results can be attributed to the limited water vapour transfer allowed by the edible coating, this is the result of the crosslinking effect of the different AV gel and starch molecules that allows a more controlled decay of the strawberries in commercial storage conditions.
Nanoemulsion as advanced edible coatings to preserve the quality of fresh‐cut fruits and vegetables: a review
Authors: Hasan S. M. Kamrul , Ferrentino Giovanna , Scampicchio Matteo 
Published: July 2019

SummaryThe increasing consumer's demand regarding the healthy diet has promoted the research towards novel approaches for preserving minimally processed fruits and vegetables without the necessity of using preservatives. Emulsion‐based edible coatings technology is considered a valuable alternative to improve fresh‐cut fruit and vegetable quality. This review discusses some recent advances for the preservation of the quality and safety of fresh‐cut fruits and vegetables with respect to the use of nanoemulsion‐based edible coatings as carrier of functional compounds such as antimicrobial agents, antioxidants and texture enhancers. It focuses especially on the use of natural functional compounds in food preservation as an alternative to synthetic additives. Moreover, the preparation and characterisation of nanoemulsion are also reviewed.
Molecular prevalence of thalassemia and hemoglobinopathies among the Lao Loum Group in the Lao People’s Democratic Republic
Authors: Phanmany Sayphonh , Chanprasert Supantitra , Munkongdee Thongperm , Svasti Saovaros , Leecharoenkiat Kamonlak 
Published: July 2019

AbstractIntroductionThalassemias and hemoglobinopathies are the most prevalent inherited anemias detected in South East Asians. These disorders represent not only a clinical health problem but also a socioeconomic problem for this region. Regarding the prevention and control of thalassemias and hemoglobinopathies in the Lao PDR, screening and diagnostic strategies should be strongly considered. The knowledge about the prevalence and molecular genotyping of thalassemias and hemoglobinopathies among the Lao Loum group, which includes the majority of Lao people, is now limited, making the prevention and control of thalassemias difficult.MethodsThis study aimed to determine the prevalence of thalassemia among Lao Loum subjects of reproductive age. Multiplex gap PCR and direct sequencing were used to investigate the mutations of α‐globin and β‐globin genes.ResultsThalassemias and hemoglobinopathies were detected in 154 of 354 (43.50%) patients, and 22 different genotypes were identified in this cohort. Remarkably, high frequencies of hemoglobin E, α0 –thalassemia (‐‐SEA), and α+ –thalassemia (‐α3.7) were noted. A variety of hematologic features was observed, including co‐inheritance of heterozygous HbE and heterozygous α‐thalassemia, which was associated with significantly lower levels of MCV and MCH values than those observed in typical HbE heterozygotes. Female participants who were heterozygous for β0 or co‐inheritance of heterozygous βE with heterozygous α‐thalassemia exhibited mild anemia.ConclusionOur data show that thalassemias and hemoglobinopathies have become health problems imposing a serious burden in the Lao PDR. Prevention programs aimed at decreasing the incidence of severe thalassemia diseases should be designed and initiated.
Performance evaluation of new Abbott Alinity hq hematology analyzer
Authors: Woo Kwang‐Sook , Jeong In‐Hwa , An Gyu‐Dae , Lim Hyeon‐Ho , Han Jin‐Yeong 
Published: July 2019

AbstractIntroductionAbbott Alinity hq is a next‐generation automated hematology analyzer providing complete blood count (CBC) with 6‐part white blood cells (WBC) differential counts. The purpose of this study was to evaluate the performance of the analyzer to verify the diagnostic and clinical utility of the Abbott Alinity hq automated system.MethodsWe evaluated specimen stability, precision, linearity, carry‐over, and method comparison to assess the performance of Alinity hq. For comparison of the Alinity hq with Sysmex XN‐9000, totally 314 samples from adult and pediatric patients including both normal and abnormal hematology profiles were analyzed in parallel. The Alinity hq was also compared with the manual differential counts for the same 314 samples.ResultsAt 4°C, the Alinity hq analyzer showed no significant changes in CBC and WBC differential count up to 48 hours. When stored at room temperature (18‐25°C), all parameters except the mean platelet volume (MPV) were stable up to 36 hours. The Abbott Alinity hq analyzer demonstrated excellent reproducibility and between‐batch precision for all CBC and WBC differential parameters. WBC, red blood cells (RBC), hemoglobin (HGB), and platelets showed good linearity and acceptable carry‐over. Comparison with a Sysmex XN‐9000 analyzer and manual 400‐cell differential showed excellent correlation for CBC and WBC differential count parameters (correlation coefficient = 0.815‐0.999) except for mean corpuscular hemoglobin concentration (MCHC) and basophils.ConclusionWe performed initial validation studies and confirmed performance specifications on specimen stability, precision, linearity, carry‐over, and method comparison. The Abbott Alinity hq analyzer showed good analytical performance for all standard CBC parameters.
Modeling and improving the logistic distribution network of a hospital
Authors: Madelin Gabriel , Lahrichi Nadia 
Published: July 2019

AbstractThis paper discusses using simulation and optimization to improve the hospital‐internal distribution network, for example, how to schedule and deliver the goods, which items should go on which cart, how to manage the variable consumption in the units, etc. We use a real case to build a simulation model to test various processes and incorporate an optimization algorithm to find the best distribution routes. The results highlight concrete improvements that could be made. These are the use of the same cart for different types of supplies to reduce the number of routes, the reduction of the distribution frequency for certain care units, and the use of optimized routes to reduce the transportation time.