bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female entrepreneurial networking in the marketing services sector
Authors: Foster Carley , Brindley Clare 
Published: February 2018

PurposeNetworking is a key element of entrepreneurial and SME activity. The skills required to network share similarities to those of a marketer and can be associated with feminine traits, such as relationship building. Yet, little is known about how female SME marketers engage in networking. This study aims to address this gap by exploring how self-employed female services marketers build, use and value networks over the lifetime of their business.Design/methodology/approachIn-depth narrative interviews were conducted with 26 self-employed women working in the UK marketing services sector. Template analysis was used to analyse the materials.FindingsA model encapsulates the fluid nature of the networking activity throughout the lifetime of the participants’ businesses by illustrating which networks the women used and their perceived value. Networking led to multi-directional outsourcing opportunities and philanthropic marketing activity, all of which supported the success of the SME. Despite support from family, friends and the community, these were not regarded as networks by the women.Practical implicationsAt the individual level, insights are offered into which networking activity is more valuable for female entrepreneurs working in the sector. For policymakers, the study indicates that participants did not see value in the formal, government networks and the women did not engage with professional bodies. More creative solutions to supporting female marketing entrepreneurs are required.Originality/valueThe study is original, in that it offers qualitative insights into how self-employed female marketers use and value networks throughout the lifetime of their business. It concentrates on one sector (marketing services) and so answers criticisms that studies in entrepreneurship do not consider specific sectors. In contrast to studies which focus on one stage of the business lifecycle, this research contributes to a holistic, longitudinal understanding of entrepreneurial female networking activity in marketing. More generally, it contributes to the paucity of literature which explores the reality of working in the marketing services sector.
Disseminating environmental ethics and values: a study of ecotourism business owners
Authors: Bowles Leonie , Ruhanen Lisa 
Published: February 2018

PurposeEstablishing a shared understanding of the environment and sustainable development between stakeholders should be fundamental to theraison d'êtreof ecotourism businesses. Indeed, many will begin ecotourism businesses with the objective of sharing their own personal environmental ethics and values with their customers through the tourism experience. Yet it is not always the business owner that interacts with the customer, the organisations’ employees will also interact with the guest and are thus responsible for communicating the environmental ethics and values that underpin the business. The purpose of this paper is to explore how ecotourism business owners ensure that their employees convey their environmental ethics and values to their customers. So how do ecotourism business owners ensure that employees convey their environmental ethics and values to their customers?Design/methodology/approachThis paper reports on the findings of interviews with 18 eco-tourism business owners in Australia who sought to examine their strategies for disseminating environmental ethics and values with the organisation’s employees.FindingsIt was found that strategic recruitment to attract like-minded employees was important which was reinforced through education, training and mentoring to develop an organisational culture underpinned by shared values and responsibility.Originality/valueThis study has contributed to the growing body of literature focused on the supply side of ecotourism businesses. It has addressed a gap in our understanding by specifically investigating the strategies that ecotourism business owners adopt to disseminate their personal environmental ethics and values to their employees.
Politics of The Ring: Limits to Public Participation in Engineering Practice
Authors: Hillier Joseph 
Published: February 2018

AbstractHow engineering in the context of urban socio‐environmental challenges is practically and effectively mobilized has been the subject of some debate. Numerous professional bodies have encouraged engineers to approach socio‐environmental issues through increased engagement with, and accountability to, the public through effective participatory practices. This article presents a close empirical analysis of a major engineering project in London to argue that engineering has a more complex relationship with social, political and environmental conditions than the idealistic participatory conception supposes. In fact, the spatial, technical and economic arrangements of engineering practice may limit the potential for public participation. Through a detailed analysis of the example of the London Water Ring Main (from around 1988 to 1994), this article shows how myriad sometimes conflicting engineering issues and responsibilities interfered with key elements of effective participation. Therefore, although increased public engagement in engineering may be desirable in theory, substantial professional, institutional and political change may have to occur before this is possible in practice.
The Engineer and The Plumber: Mediating Mumbai's Conflicting Infrastructural Imaginaries
Authors: Björkman Lisa 
Published: February 2018

AbstractTwo decades ago, the rules governing the provision of piped municipal water supply in Mumbai became linked to the policy frameworks governing eligibility for a property titling scheme. This article outlines the ideological basis and practical implications of the shift, as well as the contradictions of the new regulatory regime. The article demonstrates how these contradictions have been mediated by the material and practical knowledge, embodied expertise, local authority and wide‐ranging socio‐political work of two sets of actors: municipal water engineers and a cast of characters known locally as ‘plumbers’. The social, political and hydraulic imaginaries animating the work of ‘plumbing’ are bound up with a temporal and spatial imaginary distinctly at odds with the network‐flow conception of hydraulic engineering within which the work of water supply planning and distribution in Mumbai is conceptualized, materialized and institutionalized. The hydraulic and legal contradictions of these clashing infrastructural idioms––of flow and event––have rendered the regulatory framework highly unstable. These contradictions eventually erupted in Mumbai's waterscape, leaving the city's water infrastructures suspended in a highly politicized state of limbo between dueling infrastructural imaginaries.
Delinquencies, Default and Borrowers' Strategic Behavior toward the Modification of Commercial Mortgages
Authors: Buschbom Stephen L. , Kau James B. , Keenan Donald C. , Lyubimov Constantine 
Published: February 2018

AbstractThis article constructs a model of mortgage delinquency which tests the extent to which borrowers anticipate a loan modification resulting from such a delinquency. Using a sample of modified loans from commercial mortgage‐backed securities (CMBS), we estimate the present value of modified cash flows and project modification benefits each month for all CMBS loans which serve to proxy for a borrower's anticipation of a beneficial modification. Our results confirm a borrower's anticipation of a modification increases the delinquency hazard, and supports the theory that borrower delinquency is strategically endogenous.
Nurr1 promotes neurogenesis of dopaminergic neuron and represses inflammatory factors in the transwell coculture system of neural stem cells and microglia
Authors: Chen Xiao‐Xiang , Qian Yuan , Wang Xiang‐Peng , Tang Zhi‐Wei , Xu Jiao‐Tian , Lin Hai , Yang Zhi‐Yong , Song Xiao‐Bin , Lu Di , Guo Jia‐Zhi , Bian Li‐Gong , Li Yu , Zhou Lei , Deng Xing‐Li 
Published: February 2018

SummaryIntroductionNeural stem cells (NSCs) are the most promising cells for cell replacement therapy for Parkinson's disease (PD). However, a majority of the transplanted NSCs differentiated into glial cells, thereby limiting the clinical application. Previous studies indicated that chronic neuroinflammation plays a vital role in the degeneration of midbrain DA (mDA) neurons, which suggested the developing potential of therapies for PD by targeting the inflammatory processes. Thus, Nurr1 (nuclear receptor‐related factor 1), a transcription factor, has been referred to play a pivotal role in both the differentiation of dopaminergic neurons in embryonic stages and the maintenance of the dopaminergic phenotype throughout life.AimThis study investigated the effect of Nurr1 on neuroinflammation and differentiation of NSCs cocultured with primary microglia in the transwell coculture system.ResultsThe results showed that Nurr1 exerted anti‐inflammatory effects and promoted the differentiation of NSCs into dopaminergic neurons.ConclusionsThe results suggested that Nurr1 protects dopaminergic neurons from neuroinflammation insults by limiting the production of neurotoxic mediators by microglia and maintain the survival of transplanted NSCs. These phenomena provided a new theoretical and experimental foundation for the transplantation of Nurr1‐overexpressed NSCs as a potential treatment of PD.
Sensitivity to the Sampling Process Emerges From the Principle of Efficiency
Authors: Jara‐Ettinger Julian , Sun Felix , Schulz Laura , Tenenbaum Joshua B. 
Published: February 2018

AbstractHumans can seamlessly infer other people's preferences, based on what they do. Broadly, two types of accounts have been proposed to explain different aspects of this ability. The first account focuses on spatial information: Agents' efficient navigation in space reveals what they like. The second account focuses on statistical information: Uncommon choices reveal stronger preferences. Together, these two lines of research suggest that we have two distinct capacities for inferring preferences. Here we propose that this is not the case, and that spatial‐based and statistical‐based preference inferences can be explained by the assumption that agents are efficient alone. We show that people's sensitivity to spatial and statistical information when they infer preferences is best predicted by a computational model of the principle of efficiency, and that this model outperforms dual‐system models, even when the latter are fit to participant judgments. Our results suggest that, as adults, a unified understanding of agency under the principle of efficiency underlies our ability to infer preferences.
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema
Authors: Tolliver Starling , Graham Jaqueline , Kaffenberger Benjamin H. 
Published: February 2018

AbstractNecrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome. It presents with annular eruptions of migrating erythematous papules and plaques with superficial epidermal necrosis, central flaccid bullae, and crusted erosions located primarily in the intertriginous areas. Treatment with the long‐acting somatostatin analog Octreotide is a potential therapy to help ameliorate skin symptoms. We present a case of a patient with a 1‐year history of a pancreatic glucagonoma that developed an ulcerated, plaque‐like, weeping rash over multiple areas of their body despite current treatment with Octreotide and stable pancreatic tumor staging. The patient had a similar rash when initially diagnosed with a glucagonoma, and it quickly improved after Octreotide treatment. Clinical examination and biopsy were consistent with necrolytic migratory erythema due to an underlying glucagonoma. This rare case adds to our understanding of the clinical presentation of NME, as well as highlights the relapsing and remitting course, even if the underlying pancreatic tumor is stable and the patient is undergoing treatment.
Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review
Authors: Eshghipour Baharak , Tofighi Hamid , Nehal Faham , Vohra Fahim , Javed Fawad , Akram Zohaib 
Published: February 2018

AbstractIn the present study, the impact of scaling and root planing (SRP) on gingival crevicular fluid (GCF) cytokine/chemokine levels in smokers with chronic periodontitis was assessed. The PICO (population, intervention, comparison, outcome) question was: In smokers with chronic periodontitis (population), what is the effect of SRP (intervention) in comparison to SRP in non‐smokers with chronic periodontitis (comparison) on the GCF cytokine/chemokine level (outcome)? Indexed databases were searched up to September 2017. Of 4330 titles, nine studies reporting the levels of 13 different cytokines/chemokines were included. Eight studies had a moderate risk of bias, while one study had a high risk of bias. Almost all cytokines/chemokines were pro‐inflammatory cytokines. Five cytokines/chemokines studied in four clinical studies were decreased in the smoker‐chronic periodontitis group following SRP. One study observed that the GCF levels of interleukin‐17 increased, while anti‐inflammatory osteoprotegerin was reduced in both the SCP and non‐smoker‐chronic periodontitis groups at follow up. However, the majority of cytokines/chemokines did not change in the SCP groups at follow up. The current weight of evidence is not sufficient to prove that SRP has an impact on GCF cytokine/chemokine profile in smokers with chronic periodontitis. Evaluation of wide panels of pro‐inflammatory cytokines/chemokines related to collagen degradation and alveolar bone destruction in future studies are warranted.
Sexual Minority Adults: A National Survey on Depression, Religious Fundamentalism, Parent Relationship Quality & Acceptance
Authors: Heiden‐Rootes Katie , Wiegand Ashley , Bono Danielle 
Published: February 2018

Sexual minority persons from religious families may experience low acceptance by parents, however, little is known about the relationship of religiosity and parent relationships on mental health into adulthood. This study sought to test a moderated mediation model predicting depression based on religious fundamentalism, parent acceptance, and parent‐child relationship quality. Sexual minority adult participants (n = 384) from across the U.S. completed a web‐based, anonymous survey. Results found a conditional indirect effect of religious fundamentalism on depression through parent acceptance with the parent‐child relationship quality moderating the relationship between parent acceptance and depression. This was significant up to age 52. Clinical implications and future research with sexual minority adults and their families are explored.
What Makes a Good Trader? On the Role of Intuition and Reflection on Trader Performance
Authors: CORGNET BRICE , DESANTIS MARK , PORTER DAVID 
Published: February 2018

ABSTRACTUsing laboratory experiments, we provide evidence on three factors influencing trader performance: fluid intelligence, cognitive reflection, and theory of mind (ToM). Fluid intelligence provides traders with computational skills necessary to draw a statistical inference. Cognitive reflection helps traders avoid behavioral biases and thereby extract signals from market orders and update their prior beliefs accordingly. ToM describes the degree to which traders correctly assess the informational content of orders. We show that cognitive reflection and ToM are complementary because traders benefit from understanding signals’ quality only if they are capable of processing these signals.
Deleterious effect of anti‐angiotensin II type 1 receptor antibodies detected pretransplant on kidney graft outcomes is both proper and synergistic with donor‐specific anti‐HLA antibodies
Authors: Malheiro Jorge , Tafulo Sandra , Dias Leonídio , Martins La Salete , Fonseca Isabel , Beirão Idalina , Castro‐Henriques António , Cabrita António 
Published: February 2018

AbstractAimBoth donor‐specific antibodies (DSA) and anti‐angiotensin II type 1 receptor antibodies (AT1R‐abs) have been associated with poor graft outcomes after kidney transplantation (KT). We aimed to understand the impact of pretransplant AT1R‐abs with or without concomitant DSA on KT outcomes.MethodsSeventy‐six patients transplanted in 2009 were studied. DSA (MFI > 1000) and/or AT1R‐abs (>10UI) were detected by solid‐phase assays in pre‐KT sera. Multivariable Cox regression models were used to determine independent predictors of outcomes: acute rejection (AR) and graft failure.ResultsAt transplant, 48 patients were AT1R‐abs (−)/DSA (−), 12 AT1R‐abs (+)/DSA (−), 9 AT1R‐abs (−)/DSA (+) and 7 AT1R‐abs (+)/DSA (+). Incidence of acute rejection at 1‐year increased from 6% in AT1R‐abs (−)/DSA (−), to 35% in AT1R‐abs (+)/DSA (−), 47% in AT1R‐abs (−)/DSA (+) and 43% in AT1R‐abs (+)/DSA (+) (P < 0.001). No difference in DSA strength and C1q‐binding ability was observed between AT1R‐abs (−) /DSA (+) and AT1R‐abs (+)/DSA (+) patients. Graft survival at 6‐years was the lowest in AT1R‐abs (+)/DSA (+) (57%), followed by AT1R‐abs (+)/DSA (−) (67%), and higher in AT1R‐abs (−)/DSA (−) (94%) and AT1R‐abs (−)/DSA (+) (89%) patients (P = 0.012). AT1R‐abs (+)/DSA (−) (HR = 6.41, 95% CI: 1.43–28.68; P = 0.015) and AT1R‐abs (+)/DSA (+) (HR = 7.75, 95% CI: 1.56–38.46; P = 0.012) were independent predictors of graft failure.ConclusionAcute rejection incidence and graft failure were associated with both DSA and AT1R‐abs. These results demonstrate a proper negative effect of AT1R‐abs on graft outcomes, besides a synergistic one with DSA. Pretransplant AT1R‐abs should be acknowledged to better stratify patients’ immunological risk.
Organic zinc and copper supplementation on antioxidant protective mechanism and their correlation with sperm functional characteristics in goats
Authors: Narasimhaiah M , Arunachalam A , Sellappan S , Mayasula VK , Guvvala PR , Ghosh SK , Chandra V , Ghosh J , Kumar H 
Published: February 2018

ContentsTrace minerals feeding had significant effects on sperm production and fertility with better absorption and proper utilization within the body for optimum reproductive function. Several studies have shown that more influenced trace elements in the diets of animals are copper (Cu) and zinc (Zn). Bucks showing deficiency of this mineral might affect the quality of semen production which in turn would affect the fertility. This experiment was thus designed to test the effects of organic Cu and Zn supplementation on antioxidants enzyme activities and sperm functional attributes in fresh semen of bucks. Forty bucks (n = 40, Aged 5 months) were assigned to ten groups of four animals in each group, supplemented (for a period of 8 months) with different levels of organic Zn: 20 mg (T2), 40 mg (T3) and 60 mg (T4), organic Cu: 12.5 mg (T5), 25 mg (T6), 37.5 mg (T7) and combined organic Zn and Cu: 20 + 12.5 mg (T8), 40 + 25 mg (T9), 60 + 37.5 mg (T10), respectively, per kg dry matter and no additional mineral diet (control; T1). One hundred and sixty semen samples were collected through electro‐ejaculator and analysed for sperm quantity, quality, acrosome intactness and plasma membrane integrity and correlated with the catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase enzyme activities in seminal plasma. The results indicated organic Cu and zinc supplemented bucks produced more sperm cells, had higher sperm concentrations, maintained higher (p < .01) sperm livability, plasma membrane and acrosome integrities, more motility and velocity. The increased antioxidant enzyme activities, reduced oxidative stress and lowered lipid peroxidation were positively correlated (p < .05) with the sperm functional attributes. In conclusion, organic Cu and Zn supplement to male goats showed protective roles against oxidative damage and maintained better fresh semen characteristics.
Public health response to an imported case of canine melioidosis
Authors: Ryan C. W. , Bishop K. , Blaney D. D. , Britton S. J. , Cantone F. , Egan C. , Elrod M. G. , Frye C. W. , Maxted A. M. , Perkins G. 
Published: February 2018

SummaryMelioidosis in humans presents variably as fulminant sepsis, pneumonia, skin infection and solid organ abscesses. It is caused by Burkholderia pseudomallei, which in the United States is classified as a select agent, with “potential to pose a severe threat to both human and animal health, to plant health or to animal and plant products” (Federal Select Agent Program, http://www.selectagents.gov/, accessed 22 September 2016). Burkholderia pseudomallei is found in soil and surface water in the tropics, especially South‐East Asia and northern Australia, where melioidosis is endemic. Human cases are rare in the United States and are usually associated with travel to endemic areas. Burkholderia pseudomallei can also infect animals. We describe a multijurisdictional public health response to a case of subclinical urinary B. pseudomallei infection in a dog that had been adopted into upstate New York from a shelter in Thailand. Investigation disclosed three human contacts with single, low‐risk exposures to the dog's urine at his residence, and 16 human contacts with possible exposure to his urine or culture isolates at a veterinary hospital. Contacts were offered various combinations of symptom/fever monitoring, baseline and repeat B. pseudomallei serologic testing, and antibiotic post‐exposure prophylaxis, depending on the nature of their exposure and their personal medical histories. The dog's owner accepted recommendations from public health authorities and veterinary clinicians for humane euthanasia. A number of animal rescue organizations actively facilitate adoptions into the United States of shelter dogs from South‐East Asia. This may result in importation of B. pseudomallei into almost any community, with implications for human and animal health.
Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
Authors: Fernández-García Laura , Fernandez-Cuenca Felipe , Blasco Lucía , López-Rojas Rafael , Ambroa Anton , Lopez María , Pascual Álvaro , Bou Germán , Tomás María 
Published: February 2018

ABSTRACT

The molecular mechanisms of tolerance and persistence associated with several compounds in
Acinetobacter baumannii
clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an
A. baumannii
strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain
A. baumannii
ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.