bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistence of anxiety symptoms after elective caesarean delivery
Authors: Janssen Anna B. , Savory Katrina A. , Garay Samantha M. , Sumption Lorna , Watkins William , Garcia-Martin Isabel , Savory Nicola A. , Ridgway Anouk , Isles Anthony R. , Penketh Richard , Jones Ian R. , John Rosalind M. 
Published: August 2018

BackgroundIn the UK, 11.8% of expectant mothers undergo an elective caesarean section (ELCS) representing 92 000 births per annum. It is not known to what extent this procedure has an impact on mental well-being in the longer term.AimsTo determine the prevalence and postpartum progression of anxiety and depression symptoms in women undergoing ELCS in Wales.MethodPrevalence of depression and anxiety were determined in women at University Hospital Wales (2015–16;n= 308) through completion of the Edinburgh Postnatal Depression Scale (EPDS; ≥13) and State-Trait Anxiety Inventory (STAI; ≥40) questionnaires 1 day prior to ELCS, and three postpartum time points for 1 year. Maternal characteristics were determined from questionnaires and, where possible, confirmed from National Health Service maternity records.ResultsUsing these criteria the prevalence of reported depression symptoms was 14.3% (95% CI 10.9–18.3) 1 day prior to ELCS, 8.0% (95% CI 4.2–12.5) within 1 week, 8.7% (95% CI 4.2–13.8) at 10 weeks and 12.4% (95% CI 6.4–18.4) 1 year postpartum. Prevalence of reported anxiety symptoms was 27.3% (95% CI 22.5–32.4), 21.7% (95% CI 15.8–28.0), 25.3% (95% CI 18.5–32.7) and 35.1% (95% CI 26.3–44.2) at these same stages. Prenatal anxiety was not resolved after ELCS more than 1 year after delivery.ConclusionsWomen undergoing ELCS experience prolonged anxiety postpartum that merits focused clinical attention.Declaration of interestNone.
Structures and Conducting Properties of Molecular Conductors Based on DM-TTP
Authors: Kinoshita Naoya , Shirahata Takashi , Misaki Yohji 
Published: August 2018

Abstract
X-ray structure analysis of (DM-TTP)2X (X = PF6, AsF6 and SbF6) was successfully performed. The arrangement of DM-TTP molecules was classified as β20-type. A tight-binding band calculation suggested these salts had a quasi-one-dimensional Fermi surface. (DM-TTP)2SbF6 exhibited metallic conductivity down to 10 K with σ⊥ = 1.4 S cm−1 at room-temperature.
Proteolytic processing of the L-type Ca2+ channel alpha11.2 subunit in neurons
Authors: Buonarati Olivia R. , Henderson Peter B. , Murphy Geoffrey G. , Horne Mary C. , Hell Johannes W. 
Published: August 2018

Background: The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α11.2 subunit. It exists in two major size forms, whose molecular masses have proven difficult to precisely determine. Recent work suggests that α11.2 is proteolytically cleaved between the second and third of its four pore-forming domains (Michailidiset al,. 2014).Methods: To better determine the apparent molecular masses (MR)of the α11.2 size forms, extensive systematic immunoblotting of brain tissue as well as full length and C-terminally truncated α11.2 expressed in HEK293 cells was conducted using six different region–specific antibodies against α11.2.Results: The full length form of α11.2 migrated, as expected, with an apparent MRof ~250 kDa. A shorter form of comparable prevalence with an apparent MRof ~210 kDa could only be detected in immunoblots probed with antibodies recognizing α11.2 at an epitope 400 or more residues upstream of the C-terminus.Conclusions: The main two size forms of α11.2 are the full length form and a shorter form, which lacks ~350 distal C-terminal residues. Midchannel cleavage as suggested by Michailidiset al. (2014) is at best minimal in brain tissue.
First draft genome assembly of the Argane tree (Argania spinosa)
Authors: Khayi Slimane , Azza Nour Elhouda , Gaboun Fatima , Pirro Stacy , Badad Oussama , Claros M. Gonzalo , Lightfoot David A. , Unver Turgay , Chaouni Bouchra , Merrouch Redouane , Rahim Bouchra , Essayeh Soumaya , Ganoudi Matika , Abdelwahd Rabha , Diria Ghizlane , Mdarhi Meriem Alaoui , Labhilili Mustapha , Iraqi Driss , Mouhaddab Jamila , Sedrati Hayat , Memari Majid , Hamamouch Noureddine , Alché Juan de Dios , Boukhatem Noureddine , Mrabet Rachid , Dahan Rachid , Legssyer Adelkhaleq , Khalfaoui Mohamed , Badraoui Mohamed , Van de Peer Yves , Tatusova Tatiana , El Mousadik Abdelhamid , Mentag Rachid , Ghazal Hassan 
Published: August 2018

Background: The Argane tree (Argania spinosa L. Skeels) is an endemic tree of southwestern Morocco that plays an important socioeconomic and ecologic role for a dense human population in an arid zone. Several studies confirmed the importance of this species as a food and feed source and as a resource for both pharmaceutical and cosmetic compounds. Unfortunately, the argane tree ecosystem is facing significant threats from environmental changes (global warming, over-population) and over-exploitation. Limited research has been conducted, however, on argane tree genetics and genomics, which hinders its conservation and genetic improvement. Methods: Here, we present a draft genome assembly of A. spinosa. A reliable reference genome of A. spinosa was created using a hybrid de novo assembly approach combining short and long sequencing reads. Results: In total, 144 Gb Illumina HiSeq reads and 7.2 Gb PacBio reads were produced and assembled. The final draft genome comprises 75 327 scaffolds totaling 671 Mb with an N50 of 49 916 kb. The draft assembly is close to the genome size estimated by k-mers distribution and covers 89% of complete and 4.3 % of partial Arabidopsis orthologous groups in BUSCO. Conclusion: The A. spinosa genome will be useful for assessing biodiversity leading to efficient conservation of this endangered endemic tree. Furthermore, the genome may enable genome-assisted cultivar breeding, and provide a better understanding of important metabolic pathways and their underlying genes for both cosmetic and pharmacological purposes.
Energy Expenditure and Nutritional Status of Sailors During One Month of Extensive Physical Training
Authors: Verma Saroj Kumar , Kirar Vandana , Singh Vijay Kumar , Rakhra Gurseen , Masih Daisy , Vats Annu , Rana Rashmi Tomar , Singh Som Nath 
Published: August 2018

The present study was conducted to determine nutritional requirements during extensive physical training by sailors of Indian Navy. A total of 37 sailors who were undergoing physical trainers course at training establishment of Indian Navy participated in this study. Energy expenditure, energy intakes, nutrient status and body composition changes during one month of training were recorded. Mean energy expenditure was found to be 4035 ±733 kcal/day and an average intake of 4478 ±340 kcal/day with sufficient amount of micro and macronutrients. The level of vitamin and minerals in blood and their excretion were in the normal range. Body composition was also maintained with a marginal decrease in body fat content. Increase in grip strength of passive hand was observed (Basal: 41.5 ± 8.8 kg, after 1 month of training: 46.5 ± 6.1 kg). Results indicate adequate nutritional support from the diet and positive effects of the training on health
Infrared and Structural Studies of Micro and Nano-crystalline Ta Doped Lead Zirconate Titanate Ceramics
Authors: Kumar Praveen , MBalasubramaniam Dr , Murty BS , Rajan KM 
Published: August 2018

<p> In this paper, influence of additives on structural properties of Tantalum (<em>Ta</em>) doped PZT ceramics, prepared by solid-state oxide and mechanical activation (MA) routes, has been studied. The Fourier transformation infrared spectroscopy (FTIR) studies, are done to understand the structural interactions, confirmed that the wave number and bond energy decreases with the increase in Ta content accompanied by decrease in grain size. FTIR spectrum becomes broader in nanocrystalline Ta-PZT. The fraction of tetragonal phase decrease along with reduction in grain size as the <em>Ta </em>content increase. The remnant polarisation and coercive field also follows the similar trend on <em>Ta </em>doping. It is seen that infrared spectroscopy results corroborate the structure and ferroelectric properties of PZT materials.</p>
Application of Spatiotemporal Fuzzy C-Means Clustering for Crime Spot Detection
Authors: Ansari Mohd Yousuf , Prakash Anand , Mainuddin Dr 
Published: August 2018

<p>The various sources generate large volume of spatiotemporal data of different types including crime events. In order to detect crime spot and predict future events, their analysis is important. Crime events are spatiotemporal in nature; therefore a distance function is defined for spatiotemporal events and is used in Fuzzy C-Means algorithm for crime analysis. This distance function takes care of both spatial and temporal components of spatiotemporal data. We adopt sum of squared error (SSE) approach and Dunn index to measure the quality of clusters. We also perform the experimentation on real world crime data to identify spatiotemporal crime clusters.</p><div> </div>
Illness beliefs of adolescents with CFS and their parents: the perceived causes of illness and beliefs about recovery
Authors: Loades Maria E. , Rimes Katharine A. , Lievesley Kate , Ali Sheila , Chalder Trudie 
Published: August 2018

AbstractThe objective here was to explore beliefs about the causes of chronic fatigue syndrome (CFS) in a cohort of adolescents with CFS and their parents, and to explore the adolescent’s beliefs about recovery. Questionnaires were administered to a clinical cohort of adolescents (n = 104) and their parents (n = 102 mothers and 63 fathers), presenting to a specialist CFS unit. These included a question about the causes of their illness. Adolescents were also asked about the projected timeline of their recovery from CFS. The most commonly endorsed causes of CFS by adolescents and their parents were a virus and/or contextual factors and stress. Adolescents and their parents were in close agreement about the causes of CFS. Most adolescents said they did not know how long it would take them to recover from CFS. Informing adolescents about the prognosis for CFS is an important aspect of treatment.
Adrenal incidentaloma – diagnostic and treating problem – own experience
Authors: Pogorzelski Ryszard , Celejewski Krzysztof , Toutounchi Sadegh , Krajewska Ewa , Wołoszko Tomasz , Szostek Małgorzata , Jakuczun Wawrzyniec , Fiszer Patryk , Legocka Małgorzata , Gałązka Zbigniew 
Published: August 2018

Abstract

Introduction
Incidentaloma is defined as an tumor diagnosed accidentally using imaging studies performed due to other indications. The aim of this paper was to describe the diagnostic and treatment problems experienced by patients with adrenal incidentaloma in a clinical practice.

Material and methods
In years 2009-2012 there were 33(16,5%) adrenal tumors diagnosed incidentally out of 200 cases treated due to adrenal pathology. The group consisted of 54 patients aged 27-77. In 15(45,5%) patients the diagnosis was made based on ultrasound examination, while in 18(54,5%) the tumor was visualized in CT/MRI.

Results
Only after the diagnostics was finalized, in which in all cases no signs of hormonal activity were detected, 26(78,8%) patients were qualified for the surgery. In 7(21,2%) cases no indications for such a management were found. The latter group was followed-up and in all patients the indications for the surgery arose due to enlargement of the tumor or/and the existence of hormonal activity. Our observations suggest that the incident finding of adrenal tumor is an indication of long-term observation. The analysis of our material shows that all patients observed needed surgical treatment.

Conclusions
The small adrenal tumors under follow-up have a tendency to enlarge and acquire hormonal activity. Long-term observation significantly increases the costs of treatment in that group, which eventually results in surgical management.
Medial Auditory Thalamus Is Necessary for Expression of Auditory Trace Eyelid Conditioning
Authors: Hoffmann Loren C. , Zara S. James , DeLord Evan D. , Mauk Michael D. 
Published: August 2018

Transforming a brief sensory event into a persistent neural response represents a mechanism for linking temporally disparate stimuli together to support learning. The cerebellum requires this type of persistent input during trace conditioning to engage associative plasticity and acquire adaptively timed conditioned responses (CRs). An initial step toward identifying the sites and mechanisms generating and transmitting persistent signals to the cerebellum is to identify the input pathway. The medial auditory thalamic nuclei (MATN) are the necessary and sufficient source of auditory input to the cerebellum for delay conditioning in rodents and a possible input to forebrain sites generating persistent signals. Using pharmacological and computational approaches, we test (1) whether the necessity of MATN during auditory eyelid conditioning is conserved across species, (2) whether the MATN are necessary for the expression of trace eyelid CRs, and if so, (3)whether this relates to the generation of persistent signals. We find that contralateral inactivation of MATN with muscimol largely abolished trace and delay CRs in male rabbits. Residual CRs were decreased in amplitude, but CR timing was unaffected. Results from large-scale cerebellar simulations are consistent with previous experimental demonstrations that silencing only CS-duration inputs does not abolish trace CRs, and instead affects their timing. Together, these results suggest that the MATN are a necessary component of both the direct auditory stimulus pathway to the cerebellum and the pathway generating task-essential persistent signals.SIGNIFICANCE STATEMENTPersistent activity is required for working memory-dependent tasks, such as trace conditioning, and represents a mechanism by which sensory information can be used over time for learning and cognition. This neuronal response entails the transformation of a discrete sensory-evoked response into a signal that extends beyond the stimulus event. Understanding the generation and transmission of this stimulus transformation requires identifying the input sources necessary for task-essential persistent signals. We report that the medial auditory thalamic nuclei are required for the expression of auditory trace conditioning and suggest that these nuclei are a component of the pathway-generating persistent signals. Our study provides a foundation for testing circuit-level mechanisms underlying persistent activity in a cerebellar learning model with identified inputs and well defined behavioral outputs.
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling
Authors: Tu Yen-Kuei , Duman Joseph G. , Tolias Kimberley F. 
Published: August 2018

Excitatory synapses are specialized cell–cell contacts located on actin-rich dendritic spines that mediate information flow and storage in the brain. The postsynaptic adhesion-G protein-coupled receptor (A-GPCR) BAI1 is a critical regulator of excitatory synaptogenesis, which functions in part by recruiting the Par3-Tiam1 polarity complex to spines, inducing local Rac1 GTPase activation and actin cytoskeletal remodeling. However, a detailed mechanistic understanding of how BAI1 controls synapse and spine development remains elusive. Here, we confirm that BAI1 is requiredin vivofor hippocampal spine development, and we identify three distinct signaling mechanisms mediating BAI1's prosynaptogenic functions. Usingin uteroelectroporation to sparsely knock down BAI1 expression in hippocampal pyramidal neurons, we show that BAI1 cell-autonomously promotes spinogenesis in the developing mouse brain. BAI1 appears to function as a receptor at synapses, as its extracellular N-terminal segment is required for both its prospinogenic and prosynaptogenic functions. Moreover, BAI1 activation with aStachel-derived peptide, which mimics a tethered agonist motif found in A-GPCRs, drives synaptic Rac1 activation and subsequent spine and synapse development. We also reveal, for the first time, a trans-synaptic function for BAI1, demonstrating in a mixed-culture assay that BAI1 induces the clustering of presynaptic vesicular glutamate transporter 1 (vGluT1) in contacting axons, indicative of presynaptic differentiation. Finally, we show that BAI1 forms a receptor complex with the synaptogenic cell-adhesion molecule Neuroligin-1 (NRLN1) and mediates NRLN1-dependent spine growth and synapse development. Together, these findings establish BAI1 as an essential postsynaptic A-GPCR that regulates excitatory synaptogenesis by coordinating bidirectional trans-synaptic signaling in cooperation with NRLN1.SIGNIFICANCE STATEMENTAdhesion-G protein-coupled receptors are cell-adhesion receptors with important roles in nervous system development, function, and neuropsychiatric disorders. The postsynaptic adhesion-G protein-coupled receptor BAI1 is a critical regulator of dendritic spine and excitatory synapse development. However, the mechanism by which BAI1 controls these functions remains unclear. Our study identifies three distinct signaling paradigms for BAI1, demonstrating that it mediates forward, reverse, and lateral signaling in spines. Activation of BAI1 by aStachel-dependent mechanism induces local Rac1 activation and subsequent spinogenesis/synaptogenesis. BAI1 also signals trans-synaptically to promote presynaptic differentiation. Furthermore, BAI1 interacts with the postsynaptic cell-adhesion molecule Neuroligin-1 (NRLN1) and facilitates NRLN1-dependent spine growth and excitatory synaptogenesis. Thus, our findings establish BAI1 as a functional synaptogenic receptor that promotes presynaptic and postsynaptic development in cooperation with synaptic organizer NRLN1.
STRATEGIC IMPERATIVES UNDER ACCELERATED POSTINDUSTRIAL TRANSFORMATIONS
Authors: Volkova L. I. , Lanskaya D. V. 
Published: August 2018

The deep technological changes, update the key competences of the human factor, the related organizational and institutional changes represent the change way of economic life, resulting in the emergence of new functions of strategy development process, the study of which is repelled by the results of the development of the basic functions of strategic management, as well as takes into account the problems and contradictions of the development of regional economies, as disclosed in the current scientific literature. The article deals with the problems of strategy development of regional economic systems in the conditions of the acceleration of postindustrial transformation. The article highlights the imperatives behind switching to strategic planning and management at the regional and local levels in the market. Presented regional strategy neoindustrialization as the quintessence of regional policy for one of the regions of the country – Krasnodar region. The strengths and the weaknesses of the regional economy were analyzed and identified, some problems that prevent the region from reaching a new stage of development, offered ways of their solution.
MANAGEMENT OF THE STRATEGY OF BUSINESS OF THE ORGANIZATION ON THE BASIS OF MODEL OF LIFE CYCLE OF J. GARDNER
Authors: Tebekin A. V. 
Published: August 2018

In the system of methods of management on the basis of technologies of organizational management methods on the basis of models of management of life cycle of the organization are considered. On the basis of model of life cycle of the organization of J. Gardner the problems and the prospects of management of the strategy of business of the organization in national economy caused by the current cyclic recession of macroeconomic activity, which minimum caused by change of the V technological way by the VI are considered.
The workforce planning system of the organization
Authors: Kudryashov V. S. 
Published: August 2018

The Relevance of the research topic is due to a number of factors: first, at the present stage of development, in the context of increasing competition, companies are in constant search of sustainable and difficult to replicate sources of competitive advantage; secondly, since the second half of the twentieth century, not only in theory but also in practice of management of most organizations recognized the existence of a relationship between the effectiveness of the organization and the effectiveness of its personnel policy (and personnel planning as one of its areas, including). Initially, the purpose of this direction was, first of all, to meet the needs of human resources - the production and economic needs of "employers" in the qualified personnel necessary for the most effective and efficient functioning of the organization, and only then the socio - economic interests of "workers". Today it "extends" practically to all spheres of personnel management. Despite the recognition of marked dependence and the role of personnel planning in enhancing organizational effectiveness, for most organizations it does not become a management norm, and if it is, it is not integrated into the overall business strategy, as opposed to, for example, from production planning, product sales, investments into development and so the Current situation is not just "assumes" and "requires" practical changes in relation to, the formulation and implementation of personnel policies and direction of its improvement.
Model of obtaining competitive advantages by the companies of the restaurant industry in the russian market
Authors: Maari K. Zh. 
Published: August 2018

The article presents the main results of research study, the purpose of which was to identify the main competitive advantages of the companies of Russian restaurant industry. Speaking about the state of the restaurant business market in Russia today, it should be noted that the market of services depends on the overall economic performance of the country. Creation and development of competitive advantages will help the restaurant not to lose its market share.
Use of green area of Kastamonu: Case study of Clock Tower
Authors: SAKICI CIGDEM 
Published: August 2018

The aim of the study is to show which areas mainly prefered when the people want to carry out recreational activities in the Kastamonu city center and determine the appropriateness of this area for recreative activity. A questionnaire study was conducted with 100 randomly selected people in order to determine the most frequently used open green area in terms of recreational activity in Kastamonu and the results showed that 89% of the participants prefer the Clock Tower. Thus Clock Tower was determined as a research area in this study. It is revealed the current state of the Clock Tower in scope of the study, plants are used in this area and the purpose of use of these plants is determined and how frequently users use this area and the reasons for not frequent use. In addition, activities that are effected in the area and changes in mood after using the area. The second survey study was conducted on users of the area consisting of 118 people. It is revealed space features existing at Clock Tower and events area identified after that space features that users want to be in this area and events areas. Thus, the aim of the area is to determine the users' expectations and the deficiencies and problems in this area.