bluuebunny/crossref_metadata_2025_split huggingface dataset:
A shift from membranous and stromal syndecan‐1 (CD138) expression to cytoplasmic CD138 expression is associated with poor prognosis in breast cancer
Authors: Kind Simon , Jaretzke Annika , Büscheck Franziska , Möller Katharina , Dum David , Höflmayer Doris , Hinsch Andrea , Weidemann Sören , Fraune Christoph , Möller‐Koop Christina , Hube‐Magg Claudia , Simon Ronald , Wilczak Waldemar , Lebok Patrick , Witzel Isabell , Müller Volkmar , Schmalfeldt Barbara , Paluchowski Peter , Wilke Christian , Heilenkötter Uwe , von Leffern Ingo , Krech Till , Krech Rainer H. , von der Assen Albert , Bawahab Ahmed Abdulwahab , Burandt Eike 
Published: September 2019

AbstractSyndecan‐1 (CD138) is a transmembrane proteoglycan expressed in normal and malignant tissues. It is of interest because of a possible prognostic effect in tumors and as a target for Indatuximab, a monoclonal antibody coupled to a cytotoxic agent. To assess the prognostic role of CD138 expression in breast cancer (BCa), a tissue microarray containing 1535 BCa specimens was analyzed by immunohistochemistry. Cytoplasmic, membranous, and stromal CD138 staining was separately analyzed. In normal breast tissue, CD138 staining was limited to epithelial cell membranes. In cancers, membranous staining tended to become weaker or even disappeared (38.3% of cancers with absence of membranous staining) but cytoplasmic and stromal staining newly appeared in 29.7% and 58.1% of cancers. Loss of membranous epithelial CD138 staining as well as presence of cytoplasmic and stromal CD138 positivity were—to a variable degree—associated with high pT, high grade, nodal metastasis, estrogen receptor‐negative, progesterone receptor‐negative, human epidermal growth factor receptor 2+, and poor overall patient survival. A combined analysis of epithelial and stromal CD138 expression revealed a link to overall patient survival (P < .0001) with best prognosis for patients with stromal positivity and absence of cytoplasmic staining, the worst prognosis for cancers with cytoplasmic staining and stromal negativity and intermediate prognosis for patients having either cytoplasmic staining or stromal negativity. In multivariate analyses, CD138 was not independent of established prognostic features. In summary, these data reveal a compartment depending prognostic effect of CD138 expression in BCa with cytoplasmic positivity being linked to aggressive cancer and stromal CD138 being linked to a more favorable prognosis.
Enrichment of transplantable germ cells in salmonids using a novel monoclonal antibody by magnetic‐activated cell sorting
Authors: Ichida Kensuke , Hayashi Makoto , Miwa Misako , Kitada Ryota , Takahashi Momo , Fujihara Ryo , Boonanuntanasarn Surintorn , Yoshizaki Goro 
Published: September 2019

AbstractIn the fish germ cell transplantation system, only type A spermatogonia (ASGs) and oogonia are known to be incorporated into the recipient genital ridges, where they undergo gametogenesis. Therefore, high colonization efficiency can be achieved by enriching undifferentiated germ cells out of whole testicular cells. In this study, we used magnetic‐activated cell sorting (MACS) for enriching undifferentiated germ cells of rainbow trout using a monoclonal antibody that recognizes a specific antigen located on the germ cell membrane. We screened the antibodies to be used for MACS by performing immunohistochemistry on rainbow trout gonads. Two antibodies, nos. 172 and 189, showed strong signals for ASGs and oogonia. Next, we performed MACS with antibody no. 172 using gonadal cells isolated from vasa‐gfp rainbow trout showing GFP in undifferentiated germ cells. We found that GFP‐positive cells are highly enriched in antibody no. 172‐positive fractions. Finally, to examine the transplantability of MACS‐enriched cells, we intraperitoneally transplanted sorted or unsorted cells into recipient larvae. We observed that transplantability of sorted cells, particularly ovarian cells, were significantly higher than that of unsorted cells. Therefore, MACS with antibody no. 172 could enrich ASGs and oogonia and become a powerful tool to improve transplantation efficiency in salmonids.
Field drift correction of proton resonance frequency shift temperature mapping with multichannel fast alternating nonselective free induction decay readouts
Authors: Ferrer Cyril J. , Bartels Lambertus W. , van der Velden Tijl A. , Grüll Holger , Heijman Edwin , Moonen Chrit T. W. , Bos Clemens 
Published: September 2019

PurposeTo demonstrate that proton resonance frequency shift MR thermometry (PRFS‐MRT) acquisition with nonselective free induction decay (FID), combined with coil sensitivity profiles, allows spatially resolved B0 drift‐corrected thermometry.MethodsPhantom experiments were performed at 1.5T and 3T. Acquisition of PRFS‐MRT and FID were performed during MR‐guided high‐intensity focused ultrasound heating. The phase of the FIDs was used to estimate the change in angular frequency δωdrift per coil element. Two correction methods were investigated: (1) using the average δωdrift over all coil elements (0th‐order) and (2) using coil sensitivity profiles for spatially resolved correction. Optical probes were used for independent temperature verification. In‐vivo feasibility of the methods was evaluated in the leg of 1 healthy volunteer at 1.5T.ResultsIn 30 minutes, B0 drift led to an apparent temperature change of up to –18°C and –98°C at 1.5T and 3T, respectively. In the sonicated area, both corrections had a median error of 0.19°C at 1.5T and –0.54°C at 3T. At 1.5T, the measured median error with respect to the optical probe was –1.28°C with the 0th‐order correction and improved to 0.43°C with the spatially resolved correction. In vivo, without correction the spatiotemporal median of the apparent temperature was at –4.3°C and interquartile range (IQR) of 9.31°C. The 0th‐order correction had a median of 0.75°C and IQR of 0.96°C. The spatially resolved method had the lowest median at 0.33°C and IQR of 0.80°C.ConclusionFID phase information from individual receive coil elements allows spatially resolved B0 drift correction in PRFS‐based MRT.
Effects of Transport Duration and Water Quality on Age-0 Walleye Stress and Survival
Authors: Ball Emily Elise , Goode Katherine Jean , Weber Michael John 
Published: September 2019

Abstract
Age-0 Walleye Sander vitreus are stocked to achieve several management objectives. However, stocked Walleye are exposed to numerous handling- and transport-related stressors that can negatively influence disease resistance, survival, year-class strength, and fisheries management objectives. The objective of this study was to evaluate relationships between Walleye transport duration with changes in water chemistry, whole-blood glucose and plasma cortisol concentrations, and short-term (48-h) mortality. Walleye were transported between 3.5 and 6.0 h and stocked into holding cages located at one of seven sites. Water quality and stress (via whole-blood glucose and plasma cortisol) and mortality were evaluated prior to, during, and at 0, 2, 24, and 48 h posttransportation. During transport, water temperatures generally decreased, while carbon dioxide concentrations fluctuated between 2.7 and 22.5 mg/L. Walleye whole-blood glucose and plasma cortisol concentrations varied by site and time since transport. Changes in carbon dioxide concentrations were associated with changes in whole-blood glucose concentrations. However, cumulative survival rates and plasma cortisol concentrations were not associated with water quality or transportation duration. Understanding Walleye tolerance to transportation-induced stress has the potential to enhance stocking programs by providing the opportunity for managers to make informed transport decisions.
Clinical and Economic Value of Nutrition in Healthcare: A Nurse's Perspective
Authors: Meehan Anita , Partridge Jamie , Jonnalagadda Satya S. 
Published: September 2019

AbstractIn the US healthcare system, malnutrition is a common condition, yet it remains underreported and underdiagnosed. The financial costs of disease‐associated malnutrition are substantial; hospital‐acquired conditions, readmissions, and prolonged lengths of stay are reported to cost as much as $150 billion per year. By contrast, nutrition‐focused quality improvement programs for inpatients can help reduce the negative impact of disease‐associated malnutrition. Such programs include systematic screening for malnutrition risk on admission, timely malnutrition diagnoses, and prompt nutrition interventions, which have been shown to lower rates of hospital‐acquired infections, shorten lengths of stay, reduce readmissions, and lessen costs of care. Nurses are ideally positioned to play critical roles in nutrition‐related care—screening for malnutrition on admission, monitoring for and addressing conditions that impede nutrition intake, and ensuring that prescribed nutrition interventions are delivered and administered or consumed. Such nursing support of multidisciplinary nutrition care contributes to better patient outcomes at lower costs.
An alternative to fortified schools: Using crime prevention through environmental design (CPTED) to balance student safety and psychological well‐being
Authors: Lamoreaux Daniel , Sulkowski Michael L. 
Published: September 2019

AbstractIn response to tragic school shootings, heightened attention has been devoted to making schools safer through the implementation of security features. However, excessive security measures have a negative impact on school climate, student functioning, and academic achievement. Therefore, there is a critical need to design schools that are safe and secure, yet also welcoming and comfortable. As a promising approach in this regard, crime prevention through environmental design (CPTED) is an architectural philosophy that aims to deter criminal or antisocial behavior through environmental design, and it includes a focus on natural surveillance, access control, and territorial reinforcement. This review discusses pertinent effects of the school environment on student outcomes, extant research on the impact of visible security measures, the relationship between students’ perceptions of safety and academic functioning, and how using CPTED could concomitantly address the physical safety and psychological comfort of students at school.
Examining the relationship between grit and academic achievement within K‐12 and higher education: A systematic review
Authors: Lam Kelly Ka Lai , Zhou Mingming 
Published: September 2019

AbstractIn recent years, grit has drawn increasing attention from both researchers and practitioners. As an important noncognitive indicator, grit has been used to understand individual success and performance in various fields. However, past empirical research has shown inconsistent findings on the relationship between grit and academic achievement. This study aims to review and synthesize past empirical findings on the relationship between grit and academic achievement. Forty‐four relevant articles involving a total of 60,133 participants met the inclusion criteria and were synthesized in this meta‐analysis. Our findings suggest that (a) overall grit level and its two facets (consistency of interest and perseverance of effort) are positively associated with academic achievement; (b) the association between grit and academic achievement is moderated by grade level; and (c) perseverance of effort shows the largest effect size on students’ academic achievement when compared with overall grit level and consistency of interest.
Benzene transformation in two dielectric barrier discharge reactors having special arrangement
Authors: Dey Ghasiram 
Published: September 2019

AbstractArgon–benzene (Ar–Bz) gas phase plasma chemistry work is explored for benzene transformation employing the dielectric barrier discharge (DBD) cold plasma technique. To do so, experiments are carried out with two identical coaxial DBD reactors in serial‐type arrangements. The first carries moist Ar having 100% relative humidity (90% of total Ar flowing over water) and its outlet is mixed with Bz, which is saturated in the remaining 10% Ar at the inlet of the second reactor before plasma generation. This type of arrangement perhaps favors Bz transformation significantly for explicit products because the H2 generated in the first reactor as one of the major in situ products in the Ar‐moisture DBD system might facilitate chemical reduction of Bz to biphenyl in the second reactor during DBD. Conversely, H2O2, another product in Ar‐moisture discharge, enhances the yields of phenol. DBD outlet products, such as methane and leftover Bz, are analyzed and estimated with online gas chromatograph–flame ionization detector analysis, whereas H2 is analyzed with gas chromatograph–thermal conductivity detector. Additionally, the offline gas chromatograph–mass spectrometer analysis of acetone solutions of surface deposits obtained after discharge reveals the formation of phenol and biphenyl along with other products. The periodically analyzed data reveal that the generation of phenol, biphenyl, and CH4 relate directly to discharge duration and input moisture concentration.
Synthesis and Biological Evaluation of Novel Tetrahydro‐1,2,4‐triazines Incorporating Triazene and Tetraazene Moieties
Authors: Afsah Elsayed M. , Arab Anas M. , Abdel‐Galil Ebrahim 
Published: September 2019

AbstractDiazotization of the hydrazone (2), derived from 6‐Acetyl‐2,4‐diphenyl‐tetrahydro‐1,2,4‐triazine (1), gave the corresponding 1‐chlorotriaz‐2‐enylidene derivative 3. Coupling of 3 with resorcinol and 2‐naphthol afforded the triazenes 4 and 5. The synthesis of tetrahydro‐1,2,4‐triazine incorporating triazene and piperidine or piperazine moieties has been achieved by coupling of 3 with the respective amine. Coupling of 3 with aromatic amines and polyhydroxy amines gave the corresponding tetraazenes. Whereas, coupling with the hydrazone 2 afforded pentaazene. In addition, the coupling of aryl diazonium salts with the hydrazone 2 was investigated.
Aqueous Synthesis of 3,4‐Dihydropyridinones from Acryloyl Chloride and Enaminones by Domino Amidation and Intramolecular Michael Addition
Authors: Luo Tian , Xu Haishun , Liu Yunyun 
Published: September 2019

AbstractA facile method for the synthesis of 3,4‐dihydropyridin‐2(1H)‐ones (3,4‐dihydropyridinones) has been developed via the reactions of acryloyl chloride and enaminones. With the promotion of simple AlCl3 Lewis acid, the reactions proceed well in aqueous THF to provide diverse 3,4‐dihydropyridinones via the formation of new C−N and C−C bonds resulting from domino amidation and intramolecular Michael addition transformation.
Recent Progress on the Alloy‐Based Anode for Sodium‐Ion Batteries and Potassium‐Ion Batteries
Authors: Song Keming , Liu Chuntai , Mi Liwei , Chou Shulei , Chen Weihua , Shen Changyu 
Published: September 2019

AbstractHigh‐energy batteries with low cost are urgently needed in the field of large‐scale energy storage, such as grid systems and renewable energy sources. Sodium‐ion batteries (SIBs) and potassium‐ion batteries (PIBs) with alloy‐based anodes provide huge potential due to their earth abundance, high capacity, and suitable working potential, and are recognized as attractive alternatives for next‐generation batteries system. Although some important breakthroughs have been reported, more significant improvements are still required for long lifetime and high energy density. Herein, the latest progress for alloy‐based anodes for SIBs and PIBs is summarized, mainly including Sn, Sb, Ge, Bi, Si, P, and their oxides, sulfides, selenides, and phosphides. Specifically, the material designs for the desired Na+/K+ storage performance, phase transform, ionic/electronic transport kinetics, and specific chemical interactions are discussed. Typical structural features and research strategies of alloy‐based anodes, which are used to facilitate processes in battery development for SIBs and PIBs, are also summarized. The perspective of future research of SIBs and PIBs is outlined.
Chemical Potential-Induced Wall State Transitions in Plant Cell Growth
Authors: Pietruszka Mariusz A. 
Published: September 2019

AbstractThe pH/Tduality of acidic pH and temperature (T) action for the growth of grass shoots was examined in order to derive the phenomenological equation of wall properties for living plants. By considering non-meristematic growth as a dynamic series of state transitions (STs) in the extending primary wall, the critical exponents were identified, which exhibit a singular behaviour at a critical temperature, critical pH and critical chemical potential (μ) in the form of four power laws:$$f_{\pi } \left( \tau \right) \propto \left| \tau \right|^{\beta - 1}$$fπτ∝τβ-1,$$f_{\tau } (\pi ) \propto \left| \pi \right|^{1 - \alpha }$$fτ(π)∝π1-α,$$g_{\mu } (\tau ) \propto \left| \tau \right|^{ - 2 - \alpha + 2\beta }$$gμ(τ)∝τ-2-α+2βand$$g_{\tau } (\mu ) \propto \left| \mu \right|^{2 - \alpha }$$gτ(μ)∝μ2-α. The indicesαandβare constants, whileπandτrepresent a reduced pH and reduced temperature, respectively. The convexity relationα + β ≥ 2 for practical pH-based analysis andβ ≡ 2 “mean-field” value in microscopic (μ) representation were derived. In this scenario, the magnitude that is decisive is the chemical potential of the H+ions, which force subsequent STs and growth. Furthermore, observation that the growth rate is generally proportional to the product of the Euler beta functions ofTand pH, allowed to determine the hidden content of the Lockhart constantФ. It turned out that the pH-dependent time evolution equation explains either the monotonic growth or periodic extension that is usually observed—like the one detected in pollen tubes—in a unified account.
Additional assessment of Acute Cystitis Symptom Score questionnaire for patient-reported outcome measure in female patients with acute uncomplicated cystitis: part II
Authors: Alidjanov J. F. , Naber K. G. , Pilatz A. , Radzhabov A. , Zamuddinov M. , Magyar A. , Tenke P. , Wagenlehner F. M. 
Published: September 2019

Abstract

Purpose
Since symptomatic, non-antibiotic therapy has become an alternative approach to treat acute cystitis (AC) in women, suitable patient-reported outcome measures (PROM) are urgently needed. The aim of this part II of a larger non-interventional, case–control study was the additional assessment of the ACSS as a suitable PROM.

Methods
Data from 134 female patients with diagnosed acute uncomplicated cystitis were included in the current analysis with (1) a summary score of “Typical” domain of 6 and more; (2) at least one follow-up evaluation after the baseline visit; (3) no missing values in the ACSS questionnaire data. Six different predefined thresholds based on the scoring of the ACSS items were evaluated to define “clinical cure”, also considering the draft FDA and EMA guidelines.

Results
Of the six different thresholds tested, a summary score of the five typical symptoms of 5 and lower with no symptom more than 1 (mild), without visible blood in urine, with or without including QoL issues was favoured, which partially also could be adapted to the draft FDA and EMA guidelines. The overall patient’s clinical assessment (“Dynamic” domain) alone was not sensitive enough for a suitable PROM.

Conclusions
Scoring of the severity of symptoms is needed not only for diagnosis, but also for PROM to define “clinical cure” of any intervention, which could be combined with QoL issues. Results of the study demonstrated that the ACSS questionnaire has the potential to be used as a suitable PROM and should further be tested in prospective clinical studies.
A study on harvesting of PKL electricity
Authors: Hassan Lovelu , Khan K. A. 
Published: September 2019

Abstract
The efficiency of any electric cell or battery is very important. To keep it in mind it has been studied the columbic efficiency, voltaic efficiency and energy efficiency of a PKL (Pathor Kuchi Leaf) Quasi Voltaic Cell or Modified Voltaic Cell. It was found that the columbic efficiency data illustrated that this efficiency was lower comparing to other efficiencies may be the absence of salt bridge or separator between the electrodes. Because, our designed and fabricated PKL cell does not have any salt bridge. So that the internal resistance is lower than the traditional voltaic cell and as a result more current was found. The voltage and current changes with time and I–V characteristics for PKL unit cell, module, panel and array have also been studied. It is shown that the voltaic and energy efficiency have been studied. However, the highest efficiency was obtained for 40% PKL sap with 5% secondary salt in 55% aqueous solution, which implies that the concentration of PKL juice can play an important role regarding efficiency. It was also found that the average energy efficiency was 97.43% and it was also found that the average voltaic efficiency was 57.29%. Finally, morphological study FESEM (Field Emission Scanning Electron Microscopy) has also been performed. It is seen that the results confirmed that Zn was deposited on the Cu surface during the electro deposition process in PKL solution. Using AAS, it has been measured the concentration of [Cu2+] as a reactant ion and the concentration of [Zn2+] as a product ion those have been tabulated and graphically discussed. The variation of pH has also been studied with time and which was also tabulated and graphically discussed.
Developing real-world comparators for clinical trials in chemotherapy-refractory patients with gastric cancer or gastroesophageal junction cancer
Authors: Chau Ian , Le Dung T. , Ott Patrick A. , Korytowsky Beata , Le Hannah , Le T. Kim , Zhang Ying , Sanchez Teresa , Maglinte Gregory A. , Laurie Melissa , Abraham Pranav , Patel Dhiren , Shangguan Tong 
Published: September 2019

Abstract

Background
There are few third-line or later (3L+) treatment options for advanced/metastatic (adv/met) gastric cancer/gastroesophageal junction cancers (GC/GEJC). 3L+ Nivolumab demonstrated encouraging results in Asian patients in the ATTRACTION-2 study compared with placebo (12-month survival, 26% vs 11%), and in Western patients in the single-arm CheckMate 032 study (12-month survival, 44%). This analysis aimed to establish comparator cohorts of US patients receiving routine care in real-world (RW) clinical practice.

Methods
A 2-step matching process generated RW cohorts from Flatiron Health’s oncology database (January 1, 2011–April 30, 2017), for comparison with each trial: (1) clinical trial eligibility criteria were applied; (2) patients were frequency-matched with trial arms for baseline variables significantly associated with survival. Median overall survival (OS) was calculated by Kaplan–Meier analysis from last treatment until death.

Results
Of 742 adv/met GC/GEJC patients with at least 2 prior lines of therapy, matching generated 90 US RW ATTRACTION-2-matched patients (median OS: 3.5 months) versus 163 ATTRACTION-2 placebo patients (median OS: 4.1 months), and 100 US RW CheckMate 032-matched patients (median OS: 2.9 months) versus 42 CheckMate 032 nivolumab-treated patients (median OS: 8.5 months). Baseline characteristics were generally similar between clinical trial arms and RW-matched cohorts.

Conclusions
We successfully developed RW cohorts for comparison with data from clinical trials, with comparable baseline characteristics. Survival in US patients receiving RW care was similar to that seen in Asian patients receiving placebo in ATTRACTION-2; survival with nivolumab in CheckMate 032 appeared favorable compared with US RW clinical practice.