bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhinolithiasis: A Misleading Entity
Authors: Adib Hayat , Natout Mohamad Ali El , Zaytoun Georges , Hadi Usamah Al 
Published: September 2018

Introduction Rhinolithiasis is a rare entity; it entails a stone located in the nasal cavity. The entity presents with different signs and symptoms that can be easily confused with other more common clinical entities such as chronic rhinosinusitis. However, it can also mimic sinonasal tumors, making its proper diagnosis crucial. Materials and Methods In this article, we present a case series of 15 patients over the past 13 years between 2002 and 2015 who were seen in the clinics at the American University of Beirut Medical Center. We will shed light on the common presenting symptoms, physical examination findings, proper diagnostic modalities, and treatment options. Our data will be compared to the literature. Conclusion Rhinolithiasis could present with a wide spectrum of signs and symptoms and could be overlooked or mistaken for other diagnosis such as sinusitis or malignancy. It could be differentiated from other entities by rigid nasal endoscopy and computed tomography scan. The diagnosis of rhinolithiasis requires a high index of suspicion.
Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress
Authors: Zhang De-Liang , Ghosh Manik C. , Ollivierre Hayden , Li Yan , Rouault Tracey A. 
Published: September 2018

Abstract
Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only consumed large amounts of iron, but also returned significant amounts of iron to the blood. Erythroblast-specific Fpn knockout (Fpn KO) mice developed lower serum iron levels in conjunction with tissue iron overload and increased FPN expression in spleen and liver without changing hepcidin levels. Our results also showed that Fpn KO mice, which suffer from mild hemolytic anemia, were sensitive to phenylhydrazine-induced oxidative stress but were able to tolerate iron deficiency upon exposure to a low-iron diet and phlebotomy, supporting that the anemia of Fpn KO mice resulted from erythrocytic iron overload and resulting oxidative injury rather than a red blood cell (RBC) production defect. Moreover, we found that the mean corpuscular volume (MCV) values of gain-of-function FPN mutation patients were positively associated with serum transferrin saturations, whereas MCVs of loss-of-function FPN mutation patients were not, supporting that erythroblasts donate iron to blood through FPN in response to serum iron levels. Our results indicate that FPN of erythroid cells plays an unexpectedly essential role in maintaining systemic iron homeostasis and protecting RBCs from oxidative stress, providing insight into the pathophysiology of FPN diseases.
Bone marrow–specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis
Authors: Chorzalska Anna , Morgan John , Ahsan Nagib , Treaba Diana O. , Olszewski Adam J. , Petersen Max , Kingston Nathan , Cheng Yan , Lombardo Kara , Schorl Christoph , Yu Xiaoqing , Zini Roberta , Pacilli Annalisa , Tepper Alexander , Coburn Jillian , Hryniewicz-Jankowska Anita , Zhao Ting C. , Oancea Elena , Reagan John L. , Liang Olin , Kotula Leszek , Quesenberry Peter J. , Gruppuso Philip A. , Manfredini Rossella , Vannucchi Alessandro Maria , Dubielecka Patrycja M. 
Published: September 2018

Abstract
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors have neither curative nor MPN-stem cell-eradicating potential, indicating that other targetable mechanisms are contributing to the pathophysiology of MPNs. We previously demonstrated that Abelson interactor 1 (Abi-1), a negative regulator of Abelson kinase 1, functions as a tumor suppressor. Here we present data showing that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an MPN-like phenotype resembling human PMF. Abi1 loss resulted in a significant increase in the activity of the Src family kinases (SFKs), STAT3, and NF-κB signaling. We also observed impairment of hematopoietic stem cell self-renewal and fitness, as evidenced in noncompetitive and competitive bone marrow transplant experiments. CD34+ hematopoietic progenitors and granulocytes from patients with PMF showed decreased levels of ABI1 transcript as well as increased activity of SFKs, STAT3, and NF-κB. In aggregate, our data link the loss of Abi-1 function to hyperactive SFKs/STAT3/NF-κB signaling and suggest that this signaling axis may represent a regulatory module involved in the molecular pathophysiology of PMF.
The cytochrome P450 CYP77A4 is involved in auxin-mediated patterning of the Arabidopsis thaliana embryo
Authors: Kawade Kensuke , Li Yimeng , Koga Hiroyuki , Sawada Yuji , Okamoto Mami , Kuwahara Ayuko , Tsukaya Hirokazu , Hirai Masami Yokota 
Published: September 2018

ABSTRACT
Metabolism often plays an important role in developmental control, in addition to supporting basal physiological requirements. However, our understanding of this interaction remains limited. Here, we performed quantitative phenome analysis of Arabidopsis thaliana cytochrome P450 mutants to identify a novel interaction between development and metabolism. We found that cyp77a4 mutants exhibit specific defects in cotyledon development, including asymmetric positioning and cup-shaped morphology, which could be rescued by introducing the CYP77A4 gene. Microscopy revealed that the abnormal patterning was detected at least from the 8-cell stage of the cyp77a4 embryos. We next analysed auxin distribution in mutant embryos, as the phenotypes resembled those of auxin-related mutants. We found that the auxin response pattern was severely perturbed in the cyp77a4 embryos owing to an aberrant distribution of the auxin efflux carrier PIN1. CYP77A4 intracellularly localised to the endoplasmic reticulum, which is consistent with the notion that this enzyme acts as an epoxidase of unsaturated fatty acids in the microsomal fraction. We propose that the CYP77A4-dependent metabolic pathway is an essential element for the establishment of polarity in plant embryos.
Evaluating the performance of tools used to call minority variants from whole genome short-read data
Authors: Said Mohammed Khadija , Kibinge Nelson , Prins Pjotr , Agoti Charles N. , Cotten Matthew , Nokes D.J. , Brand Samuel , Githinji George 
Published: September 2018

Background: High-throughput whole genome sequencing facilitates investigation of minority virus sub-populations from virus positive samples. Minority variants are useful in understanding within and between host diversity, population dynamics and can potentially assist in elucidating person-person transmission pathways. Several minority variant callers have been developed to describe low frequency sub-populations from whole genome sequence data. These callers differ based on bioinformatics and statistical methods used to discriminate sequencing errors from low-frequency variants. Methods: We evaluated the diagnostic performance and concordance between published minority variant callers used in identifying minority variants from whole-genome sequence data from virus samples. We used the ART-Illumina read simulation tool to generate three artificial short-read datasets of varying coverage and error profiles from an RSV reference genome. The datasets were spiked with nucleotide variants at predetermined positions and frequencies. Variants were called using FreeBayes, LoFreq, Vardict, and VarScan2. The variant callers’ agreement in identifying known variants was quantified using two measures; concordance accuracy and the inter-caller concordance. Results: The variant callers reported differences in identifying minority variants from the datasets. Concordance accuracy and inter-caller concordance were positively correlated with sample coverage. FreeBayes identified the majority of variants although it was characterised by variable sensitivity and precision in addition to a high false positive rate relative to the other minority variant callers and which varied with sample coverage. LoFreq was the most conservative caller. Conclusions: We conducted a performance and concordance evaluation of four minority variant calling tools used to identify and quantify low frequency variants. Inconsistency in the quality of sequenced samples impacts on sensitivity and accuracy of minority variant callers. Our study suggests that combining at least three tools when identifying minority variants is useful in filtering errors when calling low frequency variants.
Diagnostic Biomarkers: Are We Moving from Discovery to Clinical Application?
Authors: Parker Lucy A , Chilet-Rosell Elisa , Hernández-Aguado Ildefonso , Pastor-Valero María , Gea Sonia , Lumbreras Blanca 
Published: September 2018

AbstractBACKGROUNDDespite considerable research investment, moving from biomarker discovery to clinical application has presented unique challenges. We aimed to evaluate progress toward clinical application of a sample of molecular- and “omics”-based diagnostic tests over a 10-year period.METHODSWe used Scopus to locate studies, published before the December 31, 2016, citing 107 original-research articles published in 2006 that assessed the diagnostic value of a molecular- or “omics”-based test. We identified diagnostic studies of the same test and disease and determined whether the article represented progress in the validation of the molecular test. We classified the types of progress: (a) clinical validation (measuring diagnostic accuracy in a series of patients similar to the population in which the test will be used in practice), (b) technical improvement, (c) extended diagnostic application (modification of the diagnostic question attended initially by the test), (d) economic evaluation, or (e) clinical use or implementation.RESULTSIn the 10-year period analyzed, 4257 articles cited the 107 diagnostic studies; 118 (2.8%) were diagnostic studies of the same test, and of these papers, 25 (21.2%) did not constitute progress toward validation of the test for use in clinical practice (potential research waste). Of the 107 molecular- or “omics”-based tests described in 2006, only 28 (26.2%) appeared to have made progress toward clinical application. Only 4 (9.1%) of 44 proteomics-based tests had made progress toward clinical application.CONCLUSIONSArticles evaluating molecular- or “omics”-based diagnostic tests are numerous in biomedical journals. Few tests have made progress toward clinical application in the 10 years following their discovery.
TEMPLATING LIFE: DNA as Nature’s Hard Drive
Authors: Hogan Mél 
Published: September 2018

Abstract
DNA is being touted as the newest and most promising storage technology, especially for fixed, long-term storage. While there have already been many successful experiments encoding/decoding data onto DNA (such as moving images, software, text and computer viruses), little reflection has been done on this kind of innovation in relation to DNA’s colonial legacy: its linking of race and genetics, forensic anthropology, DNA profiling, tracking migrational history, and so on. As such, my contribution to Public is in exploring the promise of DNA as a medium for data storage by complicating and questioning its potential as a site for ongoing conquest and/or decolonization.
Hip Hop Archives or an Archive of Hip Hop? A Remix Impulse
Authors: Campbell Mark V. 
Published: September 2018

Abstract
The archivization of hip hop history by American Universities has been a reality for at least one decade, at schools like Harvard, Cornell and Tulane. Institutions of higher learning are, in the words of Foucault producing discursive possibilities for the public life of hip hop histories, creating what is sayable (Foucault 1969:61). Simultaneously, the archivization of hip hop by American Universities is also a “privileging” project, as Mbembe suggests, conferring “status” on information that can shape the future of knowledge production (2002:20). What is at stake here, is not just the future of what can be said, but also the role of a counter, rogue or institutional archive in honouring the ethos of hip hop culture in ways that do not empty the culture of its innovative and interventional aesthetic approach topower.
I, MABEL HAMPTON, POLITICAL POWER AND THE ARCHIVE
Authors: Rogerson Steph Schem 
Published: September 2018

Abstract
The relationship between the historical production of the archive and the construction of social bodies enforced patriarchal authority in many state archives. The cultural implications of the archive and the edifice of the social body, particularly for queer, gendered and racialized bodies are explored as a duality between oppressive laws and social change. The queer archive, gathered over time through multifarious processes evokes both a sense of loss and recuperation. As a location for memory that historically has been entrenched in erasure, this essay considers how historical violence can be reorganized through anti-oppressive frameworks, where the counter-archive has agency to speak for itself. Theoretical models such as the ‘gathering together’ of data that consigns subjectivity and unifies concepts of social knowledge (Derrida, Archive Fever) is explored through a suspicion of archival logic that historically advanced social control and violence (Rancière, Politics, Identification, and Subjectivization; Sekula, The Body and The Archive). The case study is Mabel Hampton, an African-American lesbian, whose legacy is preserved at the Lesbian Herstory Archive (LHA). Hampton donated her large collection to LHA as a politicized act of queer remembrance. While, I argue the social body was a triumph for the bourgeois order, where political economy was entwined into capitalism and imperialism, and sexual conduct was converted into political behavior, Mabel Hampton demonstrates that axiomatic domination of paternal state violence can be ruptured. In her own words, her story is entrenched in systematic violence of poverty, incarceration and rape, and is a collection of exile and refusal as well as persistence and survival (Love, Feeling Backward).
Analisis Ungkapan Ikhtilafu Ummati Rahmah: Originalitas dan Validitas
Authors: Anshori Muhammad Muhammad 
Published: September 2018

AbstrakTulisan berusaha mengeksplorasi ungkapan iktilāfu ummatī raḥmah dari segi originalitas dan validitasnya. Tetapi apakah benar ungkapan tersebut hadis Nabi? Perbedaan pendapat merupakan fenomena yang telah terjadi sejak Nabi masih hidup, dipengaruhi oleh banyak faktor, seperti sosial, budaya, ekonomi, politik, bacaan dan intelektualitas seseorang. Sebenarnya iktilāfu ummatī raḥmah bukan hadis karena tidak memiliki sanad yang jelas, ia dinilai lemah oleh ulama kritikus hadis. Ungkapan tersebut masuk dalam kategori “hadis-hadis bermasalah”. Karena itu, seharusnya seseorang harus berhati-hati dalam menisbatkan sebuah ungkapan kepada Nabi.Kata Kunci: Iktilāfu Ummatī Raḥmah, Originalitas, Validitas, dan Hadis-Hadis Bermasalah.
Tradisi Ziarah Makam Masyayikh Pondok Pesantren Al Hikmah 2 (Teori Sakralitas Agama Emile Durkheim)
Authors: Widyaningsih Riri , Abdul Hanif Muhammad 
Published: September 2018

Pondok Pesantren or Islamic Boarding School is central to education, especially religious education. Pondok pesantren assessed as the most successful educational institutions in printing generation with great knowledge and morals. This is because Pondok Pesantren has a different teaching system with other educational institutions. That other system is the existence of a strong spiritual relationship between teachers and students in the sense of teaching science as well as educate the soul. This soul education is rarely found in other institutions. At Pondok Pesantren Al-Hikmah 2 Brebes, can be found one of the evidence of a strong spiritual relationship between teacher and student, that is the tradition of praying and pilgrimage to the graves of the masyayikh & muassis. This tradition is not only the evidence for the strong relationship between teacher and student, but also as an aplication of hadith that transmitted by Tirmidzi. It is mentioned at the hadith narrated by Tirmidhi, that 'alims are prayed by God and all His creatures. This tradition is also considered as implementation of living hadith because applying the value of a hadith in everyday life. In this paper, the author wants to discuss the tradition of praying and pilgrimage based on the theory of the sacredness of Emile Durkheim. As for obtaining the data, the authors refer to the book and completed with an interview to one of the alumni of Pondok Pesantren Al-Hikmah 2 who ever practice this tradition.
Kesejarahan Hadis dalam Tinjauan Teori Common Link
Authors: Suwarno Rahmadi Wibowo 
Published: September 2018

This study entitled Kesejarahan Hadis Tinjauan Teori Common Link. The background of the study is study of authenticity, origin, and history of hadith has become an interesting topic and even a debate from the beginning of Islam until now. Interesting and a debate because it concerns the authenticity of Islamic teachings. Among the new theories and worldviews in contemporary criticism of contemporary hadith are the common link theory. For it is formulated the purpose of this study is to find out how to work and understand the implications of the theory of common links to the historic Hadith of the Prophet. The results of this study indicate that the common link theory impacts on the source or origin of hadith based on whom. Differences in interpreting common links determine which hadith comes from whom. Penelitian ini berjudul "Kesejarahan Hadis Hadiah Teori Common Link". Latar belakang penelitian untuk mengetahui keaslian, asal, dan sejarah hadis telah menjadi topik yang menarik dan bahkan menjadi perdebatan sejak awal Islam hingga sekarang. Menarik dan menjadi perdebatan karena menyangkut keaslian ajaran Islam. Di antara teori-teori baru dan pandangan dunia dalam kritik kontemporer hadis adalah teori common link. Oleh karena itu dirumuskan tujuan dari penelitian ini adalah untuk mengetahui bagaimana cara kerja dan memahami implikasi dari teori common link dengan historisitas hadis Nabi. Hasil penelitian ini menunjukkan bahwa teori common link berdampak pada sumber atau asal-usul hadis yang didasarkan pada siapa (rawi atau nabi). Perbedaan dalam menafsirkan common link menentukan sebuah hadis berasal dari siapa.
Budaya Organisasi Dan Dinamika Ruang Redaksi
Authors: Hutagalung Inge 
Published: September 2018

ABSTRACT This research is a qualitative study with intrepretative paradigm, and it aims to describe and explain about how the organization culture can be also take a part in the process of gatekeping due to the publication process. The research results indicate that domination value of collectivism culture in media organization tend to lead the policy as well as the gatekeeping process for avoiding confrontation style in seeking and processing the news. In another side, the research results also indicate that domination value of individualism culture tend to lead the gatekeeping process more flexible depend on intuition and feeling of the journalist. Sometimes the journalist using a confrontation style in seeking and processing the news. However, even the media organization tend to have domination value of collectivism or individualism culture, both of them are conduct the process of gatekeeping based on the code of ethic and having an orientation to public sphere as well as their goals that are not only about making money, but also the pursuit of a certain ideal values. Keywords: value of collectivism, value of individualism, public sphere
Parody Iklan, Meningkatkan Brand Awaraness melalui Olokan
Authors: Ayu Aulia Suminar 
Published: September 2018

Abstract Usually, parody were used to show how audience dislike or resistance with certain texts. Recently, parody about the standarized herbal product , “Mastin” were circulating around social media world. This phenomenon starts from Mastin parody video on youtube. Repetitive use of Mastin' TVC lyrics, “kabar gembira untuk kita semua” was becoming new joke trend and slang on cyber and real world. On the other side, that was insulting and making people bored of that kind of joke. Either do Mastin, along with this trend, Mastin changes their TVC Jingle chord (until) three times in order to make audience didn't get drown on boredom. This text would be explained by reception analysis as methodology with Elaboration Likelihood Modes and Hirearchy of Effect Model as theoritical background. Subject of this research are people who reviewing Mastin on their webblog, and Mastin user that researcher met on real world. This study aimed to understand how audiences interpret Mastin related with this parody. Keyword: Parody, Mastin, Audience Reception Analysis, Elaboration Likelihood Model, Hirearchy of Effect Model
STRATEGI KOMUNIKASI CORPORATE SOCIAL RESPONSIBILITY (CSR) DI PT PLN (PERSERO) DISTRIBUSI JAWA TENGAH DAN DIY TAHUN 2013 - 2014
Authors: Octaviana Shoraya Lolyta 
Published: September 2018

Abstract : Corporate social responsibility has become a global issue in the community and the company. CSR programs conducted by PT PLN (Persero) Distribution Regional Central Java and Yogyakarta in the areas specially for Education, Health, Community Empowerment and Environmental Conservation has been right on target. Corporate Social Responsibility program targets, among others, that people are more concerned with the condition of the PLN, and for good imaging PLN by society. Communication strategy to the public that are used in the dissemination using print media such as newspapers and magazines nationally and locally. Electronic media using television and radio in Central Java and Yogyakarta and national, also use social media such as Facebook and Twitter.Keywords : Strategic Communication, Corporate Social Responsibility.
CYBER-COLLECTIVE ACTION NETIZEN MELALUI MEDIA SOSIAL TWITTER DENGAN HASTAG #SHAMEONYOUSBY
Authors: Hinggarwati Fat'khah Dwi 
Published: September 2018

Abstract :People use social media to communicate with others, including to give an opinions. And in this way netizen on Indonesia in giving his opinion. Netizen in Indonesia giving a protest against the government through social media twitter. They wrote the disappointment tweetwith hastag #ShameOnYouSBY. This research use qualitative descriptive analysis, and discuss about the form of cyber-collective action that occurs in a protest the netizen, and how social media activism get the support. Of research results, obtained four stages cyber-collective action that is the individual perspective, group perspective, national perspective, and transnational perspective.In addition, social media activist also uses the principle of consumption of contemporary culture in seeking the support of the masses from social media twitter.Keywords: Social Media, twitter, cyber-collective action, activist