bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful in utero stem cell transplantation in X-linked severe combined immunodeficiency
Authors: Magnani Alessandra , Jouannic Jean-Marie , Rosain Jérémie , Gabrion Aurélie , Touzot Fabien , Roudaut Cécile , Kracker Sven , Mahlaoui Nizar , Toubert Antoine , Clave Emmanuel , Macintyre Elisabeth A. , Radford-Weiss Isabelle , Alcantara Marion , Magrin Elisa , Ternaux Brigitte , Nisoy Jennifer , Caccavelli Laure , Darras Anne-Marie , Picard Capucine , Blanche Stéphane , Cavazzana Marina 
Published: January 2019

Key Points
IUT enables rapid immune reconstitution and avoids many clinical and economic problems; however, the indication is still limited. IUT may be a treatment option in select cases, eg, fetuses exposed to a significant infectious risk, where a matched sibling donor exists.
Development and use of biomaterials as wound healing therapies
Authors: Murray Rachael Zoe , West Zoe Elizabeth , Cowin Allison June , Farrugia Brooke Louise 
Published: January 2019

Abstract
There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.
Promoting weight loss in people with schizophrenia: what do we still need to learn before implementing lifestyle interventions?
Authors: Coventry Peter , Peckham Emily , Taylor Jo 
Published: January 2019

Holt et al show that a lifestyle intervention did not reduce weight in people with schizophrenia. The STEPWISE trial casts a critical focus on the challenges of improving physical health in people with schizophrenia. The trial underpins efforts to maintain momentum in overcoming the unacceptable health inequalities in this population.Declaration of interestNone.
Performance of a Hospital Pathway for Patients With a New Single Brain Mass
Authors: Arrillaga-Romany Isabel , Curry William T. , Jordan Justin T. , Cahill Daniel P. , Nahed Brian V. , Martuza Robert L. , Loeffler Jay S. , Järhult Susann J. , Muzikansky Alona , Cohen Adam B. , Singhal Aneesh B. , Goldstein Joshua N. , Batchelor Tracy T. 
Published: January 2019

WHAT WE FOUND: Length of stay and time to surgery were significantly reduced after implementation of this admission pathway. Readmission rate was not adversely affected by this change. The protocol also significantly reduced the number of unnecessary body computed tomography imaging studies obtained in this patient population. CONFOUNDING FACTORS/REAL-LIFE IMPLICATIONS: The results of this study should be interpreted with their retrospective nature in mind. Further, analysis of this admission pathway did not take into consideration patient perspective or cost implications. Finally, the authors recognize that the resources for such an operational shift may only be found in large, tertiary, referral centers. Optimized specialized care for patients with new single brain masses promotes improved health care outcomes. It may also predictively reduce health care costs and improve patient satisfaction. More research is needed in this field. Limitations to our study included the inherent limitations of a retrospective pre-post design that can make it difficult to separate the effect of a specific intervention from other factors that change over time. In addition, assessment of patient satisfaction, use of diagnostic tests beyond body imaging, and advanced cost analysis could have strengthened this study. Lastly, it should be noted that the applicability of our approach may be limited to major tertiary centers with enough resources to implement such a pathway.
The Role of Dickkopf-1 in Thyroid Hormone–Induced Changes of Bone Remodeling in Male Mice
Authors: Tsourdi Elena , Colditz Juliane , Lademann Franziska , Rijntjes Eddy , Köhrle Josef , Niehrs Christof , Hofbauer Lorenz C , Rauner Martina 
Published: January 2019

Abstract
Thyroid hormones regulate bone homeostasis, and exogenously induced hyperthyroidism and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), a determinant of bone mass. Here, we assessed the role of Dkk1 in thyroid hormone–induced changes in bone using conditional Dkk1 knockout mice. Male mice with a global (Dkk1fl/fl;Rosa26-CreERT2) or osteocyte-specific (Dkk1fl/fl;Dmp1:Cre) deletion of Dkk1 were pharmacologically rendered hypothyroid or hyperthyroid. The bone phenotype was analyzed using micro-CT analysis, dynamic histomorphometry, and serum concentrations of bone turnover markers. Hypothyroid and hyperthyroid Cre-negative mice of either Cre line revealed the expected changes in bone volume with hypothyroid mice displaying a 40% to 60% increase in vertebral trabecular bone volume, while hyperthyroid mice lost 45% to 60% of bone volume. Similar changes were observed at the spine. Interestingly, Cre-positive mice of both lines did not gain or lose as much bone at the femur when rendered hypothyroid or hyperthyroid. While Cre-negative hypothyroid mice gained 80% to 100% bone volume, Cre-positive hypothyroid mice only increased their bone volume by 55% to 90%. Similarly, Cre-negative hyperthyroid mice lost 74% to 79% bone, while Cre-positive hyperthyroid mice merely lost 40% to 54%. Despite these site-specific differences, both global and osteocyte-specific Dkk1 knockout mice displayed similar changes in bone turnover as their Cre-negative controls in the hypothyroid and hyperthyroid states. While osteoblast and osteoclast parameters were increased in hyperthyroidism, hypothyroidism potently suppressed bone cell activities. Loss of Dkk1 is not sufficient to fully reverse thyroid hormone–induced changes in bone mass and bone turnover.
Neue Studiendaten zur Therapie der tumorassoziierten venösen Thromboembolie mit DOAKs
Authors: Voigtlaender M. , Yamamura J. , Langer F. 
Published: January 2019

ZusammenfassungDie venöse Thromboembolie (VTE) ist eine häufige Komplikation bei Patienten mit maligner Grunderkrankung. Basierend auf einer verbesserten Wirksamkeit und Sicherheit gegenüber Vitamin K-Antagonisten (VKA) empfehlen aktuelle Leitlinien eine 3- bis 6-monatige Antikoagulation mit niedermolekularem Heparin (NMH) als Standardtherapie der tumorassoziierten VTE. Versorgungsdaten zeigen jedoch eine geringe Leitlinienadhärenz im klinischen Behandlungsalltag, was am ehesten auf die täglichen subkutanen Injektionen und die relativ hohen Therapiekosten zurückzuführen ist. Aufgrund ihres Einnahmemodus und ihrer im Vergleich zu VKA günstigen Pharmakokinetik stellen die direkten oralen Antikoagulantien (DOAKs) zwar eine vielversprechende Alternative dar; die Subgruppen der in die großen Zulassungsstudien eingeschlossenen Krebspatienten waren aber aufgrund ihrer Größe und Tumorcharakteristika nicht geeignet, die bisherigen Studiendaten in den klinischen Alltag zu übertragen. Mit HOKUSAI VTE Cancer (Edoxaban) und SELECT-D (Rivaroxaban) stehen nun die Ergebnisse von zwei prospektiven, randomisierten Studien zur Verfügung, die die Wirksamkeit und Sicherheit von DOAKs im Vergleich zu NMH bei Patienten mit tumorassoziierter VTE untersucht haben. In beiden Studien war die DOAK-Einnahme mit weniger VTE-Rezidiven, jedoch mit einer höheren Rate an (gastrointestinalen und urothelialen) Blutungen assoziiert. Somit wird die zukünftige Therapie der tumorassoziierten VTE unter Berücksichtigung von Patientenpräferenz und Tumorcharakteristika ein hohes Maß an Selektion und Individualisierung erfordern.
Hepatitis C Virus: No Longer a Barrier to Oncology Care
Authors: Laique Sobia N. , Vargas Hugo E. 
Published: January 2019

Abstract:
Historically, hepatitis C virus infection has posed a barrier to cancer therapies and enrollment in clinical trials for oncology patients. Oral direct acting antivirals now allow most patients, previously considered difficult to treat to be effectively (>95% sustained virologic response) and safely cured.
Creativity in language learning and teaching: Translingual practices and transcultural identities
Authors: Jones Rodney H. 
Published: January 2019

AbstractThis introduction explores the four main themes of the papers in this special issue: 1) ‘language, languaging and translanguaging’ 2) ‘mobility and space’ 3) ‘transcultural identities’ and 4) ‘institutional and individual constraints on creativity’, and discusses how engagement with these themes helps the authors to move beyond traditional notions of linguistic creativity and creative pedagogy to formulate new ways of imagining creativity in language learning based on encouraging learners to make use of the full range of their semiotic resources and social experiences when communicating.
Challenging diagnosis of thyroid hormone resistance initially as Hashimoto’s thyroiditis
Authors: Ch’ng Tong Wooi , Chin Vivian L. 
Published: January 2019

Abstract

Background
Resistance to thyroid hormone (RTH) commonly presents with goiter, attention deficit hyperactivity disorder (ADHD), short stature and tachycardia. However, due to its variable presentation with subtle clinical features, a third of the cases are mistreated, typically as hyperthyroidism.

Case presentation
A 15-year-old female with ADHD and oligomenorrhea was initially diagnosed as Hashimoto’s thyroiditis but found to have a rare heterozygous mutation in c803 C>G (p Ala 268 Gly) in the THRβ gene, confirming resistance to thyroid hormone.

Conclusions
Fluctuating thyroid function tests in addition to thyroid peroxidase antibody (TPO Ab) positivity complicated the diagnosis of RTH, initially diagnosed as Hashimoto’s thyroiditis. A high index of suspicion is needed to prevent misdiagnosis and mistreatment.
Tunable all-dielectric metasurface for phase modulation of the reflected and transmitted light via permittivity tuning of indium tin oxide
Authors: Forouzmand Ali , Salary Mohammad Mahdi , Kafaie Shirmanesh Ghazaleh , Sokhoyan Ruzan , Atwater Harry A. , Mosallaei Hossein 
Published: January 2019

Abstract
We propose an electrically tunable metasurface, which can achieve relatively large phase modulation in both reflection and transmission modes (dual-mode operation). By integration of an ultrathin layer of indium tin oxide (ITO) as an electro-optically tunable material into a semiconductor-insulator-semiconductor (SIS) unit cell, we report an approach for active tuning of all-dielectric metasurfaces. The proposed controllable dual-mode metasurface includes an array of silicon (Si) nanodisks connected together via Si nanobars. These are placed on top of alumina and ITO layers, followed by a Si slab and a silica substrate. The required optical resonances are separately excited by Si nanobars in reflection and Si nanodisks in transmission, enabling highly confined electromagnetic fields at the ITO-alumina interface. Modulation of charge carrier concentration and refractive index in the ITO accumulation layer by varying the applied bias voltage leads to 240° of phase agility at an operating wavelength of 1696 nm for the reflected transverse electric (TE)-polarized beam and 270° of phase shift at 1563 nm for the transmitted transverse magnetic (TM)-polarized light. Independent and isolated control of the reflection and transmission modes enables distinctly different functions to be achieved for each operation mode. A rigorous coupled electrical and optical model is employed to characterize the carrier distributions in ITO and Si under applied bias and to accurately assess the voltage-dependent effects of inhomogeneous carrier profiles on the optical behavior of a unit cell.
The construction of relational frame model in Chinese President Xi Jinping’s foreign visit speeches
Authors: Cheng Le , Chen Cheng 
Published: January 2019

Abstract
This study analyzes the relational frames constructed in Chinese President Xi Jinping’s foreign visit speeches at three levels – the metaphorical surface frame; the non-metaphorical surface frame; and the deep frame – with the help of corpus-based mechanisms, e.g. semantic annotation and classification, semantic network retrieval, etc. In analyzing 11 foreign visit speeches between 2012 and 2017 (amounting to 20,213 words), the study reports three major findings. First, the metaphorical relational surface frames were constructed by intimate interpersonal concepts, war concepts and physical concepts, which are commonly shared by human beings. Second, the non-metaphorical relational surface frames were constructed by highlighting audiences’ beneficiary positions. Third, the deep frames were constructed by underscoring common benefits, cultural communication, people to people communication and the concerns about war and peace. The relational frames identified are compared with the cognition of the international audiences and it shows that the two conform significantly, which improves the acceptability of the speeches. Three strategies can be summarized for diplomatic speech design. First, the presentations based on universally shared experiences and knowledge can minimize perceptive difficulties in audiences. Second, presentations highlighting the audiences’ benefits are more easily accepted. Third, the cognition conceived in the presentations should conform to the audiences’ needs and preferences. The general communication features of Xi’s foreign visit speeches illustrated in the present study may offer a discourse model for diplomatic speeches.
3D Numerical Analysis of Loading Geometry on Soil Behavior Reinforced with Geocell Element
Authors: Keshmiri Nojan , Ghareh Soheil , Kazemian Sina , Hosseinian Amir Reza 
Published: January 2019

Abstract
Considering the weakness of the soil profile against tensile forces, researchers have been continuously searching to increase the bearing capacity and shear strength and improve its properties. In some projects, the soil reinforcement method has been known as a proper method for soil improvement because of its low cost, easy implementation, and great impact on soil properties. Reinforced soil is a structure composed of two different types of materials, which minimize their weaknesses together: the soil tolerates compressive stresses, and the reinforcement elements tolerate tensile stresses. In this research, the behavior of circle foundation located on a sand bed reinforced with geocell (GC) elements (which was investigated experimentally) was assessed analytically by using the Abaqus finite element software in three-dimensional (3D) mode as well. After assuring that the results of analytical studies were appropriately correlated with the results of laboratory studies, the behavior of the soil reinforced with GC elements under other square foundations was examined by using analytical studies. The results of this study showed a 65 % increase in bearing capacity and 15 % reduction in the settlement of circle foundation if using GC elements to reinforce the soil profile. The aforementioned has been obtained from comparing the results obtained from analytical and laboratory studies, showing proper matching and alignment between them by changing the geometry of the foundation from circle to square in 3D analytic studies. There was a greater effect on the bearing capacity of square foundations when increasing the GC elements (up to 12 %) than on the bearing capacity of circle foundations. To prove the proposed innovation in this research, some of its outputs were applied for improving the soil under an old one-story building with asymmetric settlement instead of reinforced concrete piles. The settlement was stopped within six months after the completion of the soil improvement operation.
Homeologous Epistasis in Wheat: The Search for an Immortal Hybrid
Authors: Santantonio Nicholas , Jannink Jean-Luc , Sorrells Mark 
Published: January 2019

Abstract
Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redundancy between homeologous genes should result in a deviation from additivity. These epistatic interactions between homeoalleles are analogous to dominance effects, but are fixed across subgenomes through self pollination. An allopolyploid can be viewed as an immortalized hybrid, with the opportunity to select and fix favorable homeoallelic interactions within inbred varieties. We present a subfunctionalization epistasis model to estimate the degree of functional redundancy between homeoallelic loci and a statistical framework to determine their importance within a population. We provide an example using the homeologous dwarfing genes of allohexaploid wheat, Rht-1, and search for genome-wide patterns indicative of homeoallelic subfunctionalization in a breeding population. Using the IWGSC RefSeq v1.0 sequence, 23,796 homeoallelic gene sets were identified and anchored to the nearest DNA marker to form 10,172 homeologous marker sets. Interaction predictors constructed from products of marker scores were used to fit the homeologous main and interaction effects, as well as estimate whole genome genetic values. Some traits displayed a pattern indicative of homeoallelic subfunctionalization, while other traits showed a less clear pattern or were not affected. Using genomic prediction accuracy to evaluate importance of marker interactions, we show that homeologous interactions explain a portion of the nonadditive genetic signal, but are less important than other epistatic interactions.
Kelyje į epistemologinį anarchizmą
Authors: Jankauskas Skirmantas 
Published: January 2019

Straipsnyje nagrinėjami mokslo filosofijos istorinės mokyklos ir konkrečiai P. Feyerabendo mokslo dinaminių aspektų metodologiniai tyrimai. P. Feyerabendui pozityvizmas ir realizmas yra tik pažinimo interpretacijos, kurių pasirinkimą sąlygoja galimybė kritiškai vertinti mokslo rezultatus. P. Feyerabendas kritikuoja neopozityvistų mokslo pažinimo modelį ir siūlo savąjį. Atkaklumo principas turi būti derinamas su proliferacijos principu, kuris siūlo kurti ir vystyti nesuderinamas su nusistovėjusiais požiūriais teorijas net ir tuo atveju, kada šie požiūriai yra visiškai patvirtinti ir visuotinai pripažinti. P. Feyerabendo nuomone, šių abiejų principų sąveika yra esminis mokslo bruožas. Tik alternatyvių teorijų platinimas ir atkaklus jų laikymasis gali užtikrinti visapusišką teorijų galimybių išplėtojimą. P. Feyerabendas sukonstravo mokslo modelį įvertindamas kai kuriuos mokslo vyksmo ypatumus bei spręsdamas jų loginio derinimo problemas. Suvokdamas savojo modelio dirbtinumą, P. Feyerabendas apsidraudė jį paskelbdamas normatyviniu.
O Bestiário de Nemésio ou como escrever uma Zoopoética açoriana
Authors: Silva Anna 
Published: January 2019

Para problematizar o antropocentrismo epistémico, encontramos nas últimas décadas do século XX e início do século XXI o desenvolvimento de um novo campo de investigação denominado Estudos Animais. Neste novo campo, o enfoque das investigações entrecruza várias linhas de pesquisa em ciências humanas e biológicas abarcando tanto a bioética e a biopolítica como as reflexões históricas, antropológicas, filosóficas e literárias. Entre os autores pioneiros que buscaram desconstruir e reconfigurar fora da esfera do antropocentrismo o próprio conceito de humano, constituem referências importantes para o desenvolvimento do presente estudo as teses defendidas pelo filósofo Georges Bataille. No que tange à literatura, meu interesse recai sobre a poesia de Vitorino Nemésio que, de forma instigante, propõe novas maneiras de pensar as complexas e controversas relações entre homens e animais não humanos. *** The Bestiary of Nemésio or how to write an Azorean zoopoetic ***In order to problematize epistemic anthropocentrism, we find in the last decades of the 20th century and the beginning of the 21st century the development of a new field of research called Animal Studies. In this new field, the research approach intersects several lines of research in the human and biological sciences, encompassing both bioethics and biopolitics, as well as historical, anthropological, philosophical and literary reflections. Among the pioneer authors who sought to deconstruct and reconfigure the very concept of human being outside the sphere of anthropocentrism, the theses defended by the philosopher Georges Bataille are important references for the development of the present study. As far as literature is concerned, my interest rests on the poetry of Vitorino Nemésio, who, in an enticing way, proposes new ways of thinking about the complex and controversial relations between men and nonhuman animals.Keywords: anthropocentrism; animal studies; Nemésio; Bataille.
Hybrid Capture-Based Genomic Profiling Identifies BRAF V600 and Non-V600 Alterations in Melanoma Samples Negative by Prior Testing
Authors: Boussemart Lise , Nelson Annie , Wong Michael , Ross Jeffrey S. , Sosman Jeffrey , Mehnert Janice , Daniels Gregory , Kendra Kari , Ali Siraj Mahamed , Miller Vincent A. , Schrock Alexa B. 
Published: January 2019

AbstractBackgroundBRAF and MEK inhibitors are approved for BRAF V600-mutated advanced melanoma, with response rates of up to 70%. Responses to targeted therapies have also been observed for diverse non-V600 BRAF alterations. Thus, sensitive, accurate, and broad detection of BRAF alterations is critical to match patients with available targeted therapies.Materials and MethodsPathology reports were reviewed for 385 consecutive melanoma cases with BRAF mutations or rearrangements identified using a hybrid capture-based next-generation sequencing comprehensive genomic profiling (CGP) assay during the course of clinical care.ResultsRecords of prior BRAF molecular testing were available for 79 (21%) cases. Of cases with BRAF V600 mutations, 11/57 (19%) with available data were negative by prior BRAF testing. Prior negative BRAF results were also identified in 16/20 (80%) cases with non-V600 mutations, 2 of which harbored multiple BRAF alterations, and in 2/2 (100%) cases with activating BRAF fusions. Clinical outcomes for a subset of patients are presented.ConclusionCGP identifies diverse activating BRAF alterations in a significant fraction of cases with prior negative testing. Given the proven clinical benefit of BRAF/MEK inhibitors in BRAF-mutated melanoma, CGP should be considered for patients with metastatic melanoma, particularly if other testing is negative.