bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stellenwert der Digitalisierung im urologischen Alltag
Authors: Salem Johannes , Struck Julian Peter 
Published: May 2019

ZusammenfassungKaum eine andere digitale Technologie hat die Gesellschaft so geprägt und verändert wie das Internet. Kulturell wird die Bedeutung mit der Einführung des Buchdruckes verglichen. Im Jahr 2018 hatten über 4 Milliarden Menschen Zugang zum Internet. Etwa 80 % der Internetnutzer suchen nach Gesundheitsinformationen, am häufigsten über Krebserkrankungen. Patienten schätzen das Internet als hilfreiche Informationsmöglichkeit ein. Es existieren über 2,6 Milliarden aktive Nutzer von Sozialen Medien. Unter deutschen urologischen Weiterbildungsassistenten nutzen 97 % Soziale Medien privat oder beruflich. Insbesondere für uroonkologische Themen besteht ein großes Potential, mittels Digitalisierung die Gesundheitskompetenz der Patienten zu fördern und zur Optimierung der Patientenversorgung beizutragen. Zusammenfassend birgt die Digitalisierung ein immenses Potential für die Urologie.
Impact of Intermittent Functional Internal Iliac Artery Occlusion on Spinal Cord Blood Supply during TEVAR
Authors: Maier Sven , Morlock Julia , Benk Christoph , Kari Fabian Alexander , Siepe Matthias , Beyersdorf Friedhelm , Czerny Martin , Rylski Bartosz 
Published: May 2019

Background Measuring transcranial motor evoked potentials (EPs) and somatosensory EPs is a well-established method to assess spinal cord function during thoracic endovascular aortic repair (TEVAR). Functional occlusion of one or both internal iliac arteries by large bore sheaths during TEVAR can cause unilateral intermittently EP loss.
Methods Between 2006 and 2016, 194 patients underwent TEVAR entailing EP monitoring. The ISIS IOM System (Inomed Medizintechnik GmbH, Emmendingen, Germany) was employed in all patients. EPs were recorded after inducing anesthesia, during the procedure, and before discontinuing anesthesia.
Results We observed a unilateral intermittently EP decrease or loss in 12 (6.2%) patients. Most events were ipsilateral (9 of 12). The underlying pathologies were descending aortic aneurysm in six patients and type B dissection in six patients. An evoked-potential decrease or loss was always associated with the insertion of large bore stent-graft-introducing sheaths. The median duration of the unilaterally EP decrease or loss was 16 (10; 31) minutes (range, 2–77 minutes) with baseline values re-established at the end of the procedure after sheath removal in all cases. No patient developed irreversible symptomatic spinal cord ischemia.
Conclusion A functional occlusion of internal iliac arteries via large bore TEVAR-introducing sheaths is associated with a unilateral intermittent decrease in or loss of EPs returning to baseline after sheath removal. This observation highlights the importance of the internal iliac arteries as one of the major spinal cord's blood supply territories, and may serve as a stimulus to reduce the duration of sheath indwelling to a minimum.
Immersed in the source text
Authors: Naranjo Sánchez Beatriz 
Published: May 2019

Abstract
This study aims at exploring the phenomenon of psychological transportation in translation from an experimental approach. Firstly, we investigate whether the emotions depicted in source texts may influence the level of transportation experienced by translators. Secondly, we try to determine whether different levels of transportation in the texts can make a difference in terms of translation performance. Based on previous work about narrative transportation in products of fiction, as well as the phenomenon known as the “paradox of pleasurable sadness”, we depart from the hypothesis that sad texts lead to a higher degree of psychological transportation than happy texts (H1). Taking into account previous theories and empirical results about the benefits of visualization and emotional engagement in translation, we also predict that highly-transported participants will render higher-quality (H2) and more creative translations (H3) than low-transported participants. For this purpose, a pilot study was conducted consisting of two literary translation tasks with opposing-valence texts (happy vs. sad). Lack of statistically significant differences for our hypothesis suggests that some adjustments in the methodology would be needed to achieve conclusive results; however, we believe that further research on the impact of transportation in translation quality and creativity is still worthwhile.
Beltrami-net: domain-independent deep D-bar learning for absolute imaging with electrical impedance tomography (a-EIT)
Authors: Hamilton S J , Hänninen A , Hauptmann A , Kolehmainen V 
Published: May 2019

AbstractObjective: To develop, and demonstrate the feasibility of, a novel image reconstruction method for absolute electrical impedance tomography (a-EIT) that pairs deep learning techniques with real-time robust D-bar methods and examine the influence of prior information on the reconstruction.Approach: A D-bar method is paired with a trained convolutional neural network (CNN) as a post-processing step. Training data is simulated for the network using no knowledge of the boundary shape by using an associated nonphysical Beltrami equation rather than simulating the traditional current and voltage data specific to a given domain. This allows the training data to be boundary shape independent. The method is tested on experimental data from two EIT systems (ACT4 and KIT4) with separate training sets of varying prior information.Main results: Post-processing the D-bar images with a CNN produces significant improvements in image quality measured by structural SIMilarity indices (SSIMs) as well as relativeandimage errors.Significance: This work demonstrates that more general networks can be trained without being specific about boundary shape, a key challenge in EIT image reconstruction. The work is promising for future studies involving databases of anatomical atlases.
SYZ transforms for immersed Lagrangian multisections
Authors: Chan Kwokwai , Suen Yat-Hin 
Published: May 2019

In this paper, we study the geometry of the SYZ transform on a semiflat Lagrangian torus fibration. Our starting point is an investigation on the relation between Lagrangian surgery of a pair of straight lines in a symplectic 2-torus and the extension of holomorphic vector bundles over the mirror elliptic curve, via the SYZ transform for immersed Lagrangian multisections defined by Arinkin and Joyce [Fukaya category and Fourier transform, AMS/IP Stud. Adv. Math., Amer. Math. Soc., Providence, RI, 2001] and Leung, Yau, and Zaslow [Adv. Theor. Math. Phys. 4 (2000), no. 6, 1319–1341]. This study leads us to a new notion of equivalence between objects in the immersed Fukaya category of a general compact symplectic manifold

(
M
,
ω
)

(M, \omega )

, under which the immersed Floer cohomology is invariant; in particular, this provides an answer to a question of Akaho and Joyce [J. Differential Geom. 86 (2010), no. 3, 831–500, Question 13.15]. Furthermore, if

M
M

admits a Lagrangian torus fibration over an integral affine manifold, we prove, under some additional assumptions, that this new equivalence is mirror to an isomorphism between holomorphic vector bundles over the dual torus fibration via the SYZ transform.
Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
Authors: Gravotta Diego , Perez Bay Andres , Jonker Caspar T. H. , Zager Patrick J. , Benedicto Ignacio , Schreiner Ryan , Caceres Paulo S. , Rodriguez-Boulan Enrique 
Published: May 2019

Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein receptor family that displays a large luminal domain with multiligand binding properties. Megalin localizes to the apical surface of multiple epithelia, where it participates in endocytosis of a variety of ligands performing roles important for development or homeostasis. We recently described the apical recycling pathway of megalin in Madin–Darby canine kidney (MDCK) cells and found that it is a long-lived, fast recycling receptor with a recycling turnover of 15 min and a half-life of 4.8 h. Previous work implicated clathrin and clathrin adaptors in the polarized trafficking of fast recycling basolateral receptors. Hence, here we study the role of clathrin and clathrin adaptors in megalin’s apical localization and trafficking. Targeted silencing of clathrin or the γ1 subunit of clathrin adaptor AP-1 by RNA interference in MDCK cells disrupted apical localization of megalin, causing its redistribution to the basolateral membrane. In contrast, silencing of the γ2 subunit of AP-1 had no effect on megalin polarity. Trafficking assays we developed using FM4-HA-miniMegalin-GFP, a reversible conditional endoplasmic reticulum–retained chimera, revealed that clathrin and AP-1 silencing disrupted apical sorting of megalin in both biosynthetic and recycling routes. Our experiments demonstrate that clathrin and AP-1 control the sorting of an apical transmembrane protein.
Closing the gap between formats for storing layout information in systems biology
Authors: Hoksza David , Gawron Piotr , Ostaszewski Marek , Hasenauer Jan , Schneider Reinhard 
Published: May 2019

AbstractThe understanding of complex biological networks often relies on both a dedicated layout and a topology. Currently, there are three major competing layout-aware systems biology formats, but there are no software tools or software libraries supporting all of them. This complicates the management of molecular network layouts and hinders their reuse and extension. In this paper, we present a high-level overview of the layout formats in systems biology, focusing on their commonalities and differences, review their support in existing software tools, libraries and repositories and finally introduce a new conversion module within the MINERVA platform. The module is available via a REST API and offers, besides the ability to convert between layout-aware systems biology formats, the possibility to export layouts into several graphical formats. The module enables conversion of very large networks with thousands of elements, such as disease maps or metabolic reconstructions, rendering it widely applicable in systems biology.
AlphaFold at CASP13
Authors: AlQuraishi Mohammed 
Published: May 2019

Abstract
Summary: Computational prediction of protein structure from sequence is broadly viewed as a foundational problem of biochemistry and one of the most difficult challenges in bioinformatics. Once every two years the Critical Assessment of protein Structure Prediction (CASP) experiments are held to assess the state of the art in the field in a blind fashion, by presenting predictor groups with protein sequences whose structures have been solved but have not yet been made publicly available. The first CASP was organized in 1994, and the latest, CASP13, took place last December, when for the first time the industrial laboratory DeepMind entered the competition. DeepMind's entry, AlphaFold, placed first in the Free Modeling (FM) category, which assesses methods on their ability to predict novel protein folds (the Zhang group placed first in the Template-Based Modeling (TBM) category, which assess methods on predicting proteins whose folds are related to ones already in the Protein Data Bank.) DeepMind's success generated significant public interest. Their approach builds on two ideas developed in the academic community during the preceding decade: (i) the use of co-evolutionary analysis to map residue co-variation in protein sequence to physical contact in protein structure, and (ii) the application of deep neural networks to robustly identify patterns in protein sequence and co-evolutionary couplings and convert them into contact maps. In this Letter, we contextualize the significance of DeepMind's entry within the broader history of CASP, relate AlphaFold's methodological advances to prior work, and speculate on the future of this important problem.
Disordered Punishment: Workaround Technologies of Criminal Records Disclosure and the Rise of a New Penal Entrepreneurialism
Authors: Corda Alessandro , Lageson Sarah E 
Published: May 2019

AbstractThe privatization of punishment is a well-established phenomenon in modern criminal justice operations. Less understood are the market and technological forces that have dramatically reshaped the creation and sharing of criminal record data in recent years. Analysing trends in both the United States and Europe, we argue that this massive shift is cause to reconceptualize theories of penal entrepreneurialism to more directly address the role of technology and commercial interests. Criminal records, or proxies for them, are now actively produced and managed by third parties via corporate decision-making processes, rather than government dictating boundaries or outsourcing duties to private actors. This has led to what we term ‘disordered punishment’, imposed unevenly and inconsistently across multiple platforms, increasingly difficult for both government and individuals to control.
Putting Coercive Control into Practice: Problems and Possibilities
Authors: Barlow Charlotte , Johnson Kelly , Walklate Sandra , Humphreys Les 
Published: May 2019

AbstractThere is growing international interest in translating Stark’s concept of coercive control into criminal justice policy and practice. In December 2015 an offence of coercive control was introduced in England and Wales. This paper offers an empirical investigation of the problems and possibilities associated with the translation of this offence into practice in one police force area in England. The findings offer some scope for optimism in response to patterns of abuse, but they also support the view that the current gender-neutral version of the legislation requires revision; there is a need for greater resourcing and training to improve understandings of the nature and impact of coercive control at all points of contact within the criminal justice process and finally, it remains the case that effective responses to domestic abuse need to be genuinely holistic.
Inter-Individual Differences in Striatal Connectivity Is Related to Executive Function Through Fronto-Parietal Connectivity
Authors: Darki Fahimeh , Sauce Bruno , Klingberg Torkel ,   for the Pediatric Imaging, Neurocognition, and Genetics Study
Published: May 2019

Abstract
The striatum has long been associated with cognitive functions, but the mechanisms behind this are still unclear. Here we tested a new hypothesis that the striatum contributes to executive function (EF) by strengthening cortico-cortical connections. Striatal connectivity was evaluated by measuring the resting-state functional connectivity between ventral and dorsal striatum in 570 individuals, aged 3–20 years. Using structural equation modeling, we found that inter-individual differences in striatal connectivity had an indirect effect (via fronto-parietal functional connectivity) and a direct effect on a compound EF measure of working memory, inhibition, and set-shifting/flexibility. The effect of fronto-parietal connectivity on cognition did not depend on age: the influence was as strong in older as younger children. In contrast, striatal connectivity was closely related to changes in cognitive ability during childhood development, suggesting a specific role of the striatum in cognitive plasticity. These results support a new principle for striatal functioning, according to which striatum promotes cognitive development by strengthening of cortico-cortical connectivity.
Antibiotic Prescribing and Respiratory Viral Testing for Acute Upper Respiratory Infections Among Adult Patients at an Ambulatory Cancer Center
Authors: Krantz Elizabeth M , Zier Jacqlynn , Stohs Erica , Ogimi Chikara , Sweet Ania , Marquis Sara , Klaassen John , Pergam Steven A , Liu Catherine 
Published: May 2019

Abstract

Background
Outpatient antibiotic prescribing for acute upper respiratory infections (URIs) is a high-priority target for antimicrobial stewardship that has not been described for cancer patients.

Methods
We conducted a retrospective cohort study of adult patients at an ambulatory cancer center with URI diagnoses from 1 October 2015 to 30 September 2016. We obtained antimicrobial prescribing, respiratory viral testing, and other clinical data at first encounter for the URI through day 14. We used generalized estimating equations to test associations of baseline factors with antibiotic prescribing.

Results
Of 341 charts reviewed, 251 (74%) patients were eligible for analysis. Nearly one-third (32%) of patients were prescribed antibiotics for URIs. Respiratory viruses were detected among 85 (75%) of 113 patients tested. Antibiotic prescribing (P = .001) and viral testing (P &lt; .001) varied by clinical service. Sputum production or chest congestion was associated with higher risk of antibiotic prescribing (relative risk [RR], 2.3; 95% confidence interval [CI], 1.4–3.8; P &lt; .001). Viral testing on day 0 was associated with lower risk of antibiotic prescribing (RR, 0.4; 95% CI 0.2–0.8; P = .01), though collinearity between viral testing and clinical service limited our ability to separate these effects on prescribing.

Conclusions
Nearly one-third of hematology–oncology outpatients were prescribed antibiotics for URIs, despite viral etiologies identified among 75% of those tested. Antibiotic prescribing was significantly lower among patients who received an initial respiratory viral test. The role of viral testing in antibiotic prescribing for URIs in outpatient oncology settings merits further study.
Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy
Authors: Lim Tingsen Benson , Aliwarga Edita , Luu Tuan Danh Anh , Li Yiqing Peter , Ng Shi Ling , Annadoray Lavenniah , Sian Stephanie , Ackers-Johnson Matthew Andrew , Foo Roger Sik-Yin 
Published: May 2019

AbstractAimsWe and others have previously described the expression landscape of circular RNA (circRNA) in mouse and human hearts. However, the functional relevance of many of these abundantly expressed cardiomyocyte circRNA remains to be fully explored. Among the most abundant circRNA, one stems from the sodium-calcium exchanger gene, Slc8a1, exon 2 locus. Because of its very high abundance in cardiomyocytes we investigated the possible role of circSlc8a1 in the heart.Methods and resultsWe performed a miRNA screen using an array of 752 miRNAs with RNA recovered from a pull-down of endogenous cardiomyocyte circSlc8a1. MicroRNA-133a (miR-133a), with a prior well-recognized role in cardiac hypertrophy, was highly enriched in the fraction of circSlc8a1 pull-down (adjusted P-value < 0.001). We, therefore, followed-up validation of the functional interaction between circSlc8a1 and miR-133 using luciferase assays and reciprocal pull-down assays. In vivo, AAV9-mediated RNAi knockdown of circSlc8a1 attenuates cardiac hypertrophy from pressure-overload, whereas forced cardiomyocyte specific overexpression of circSlc8a1 resulted in heart failure. Molecular analyses showed targets of miR-133a including serum response factor (Srf), connective tissue growth factor (Ctgf), adrenoceptor beta 1 (Adrb1), and adenylate cyclase 6 (Adcy6) to be regulated by circSlc8a1-directed intervention of knockdown and overexpression.ConclusionIn summary, circSlc8a1 can function as an endogenous sponge for miR-133a in cardiomyocytes. We propose that circSlc8a1 may serve as a novel therapeutic target for cardiac hypertrophy.
Phenology, Distribution, and Diversity of Dung Beetles (Coleoptera: Scarabaeidae) in North Florida’s Pastures and Forests
Authors: Conover Derrick , Dubeux Jose , Martini Xavier 
Published: May 2019

Abstract
Dung beetles are important to ecosystems as they aid in nutrient recycling and waste removal. In North Florida, there is a high diversity of dung beetles due to the intentional and accidental introduction of non-native species. Understanding patterns and processes on local scales is important for conservational planning. The aim of this study was to evaluate how dung beetle communities respond to different dung sources, forage composition, and habitat types. We surveyed for the presence and distribution of dung beetles in an open field and forest as well as in three types of pasture forage designs. In the first experiment, four transects with pitfall traps from forest to open field were established with either horse, pig, or cow feces bait. In the second experiment, three cattle grazing systems with different forage species were tested with only cow feces. In the first experiment, 16 species were identified between the field and forest sites including native and exotic species. Although the dung type had little effect on beetle distribution, a significantly different distribution of dung beetles between the field and forest was observed. Only one species, Onthophagus hecate Panzer (Coleoptera: Scarabaeidae) showed no preference between open field and forest habitat. During this second experiment, no difference in dung beetle distribution was found between the three types of pasture assemblages. This study supports habitat type as a driver of interspecies distribution and diversity of dung beetles in North Florida.
A new model of literary competences and the revised CEFR descriptors
Authors: Alter Grit , Ratheiser Ulla 
Published: May 2019

Abstract
This article presents a new theoretical model of literary competences for use in the language classroom. The work has been both triggered by an unintended consequence of the introduction of the original CEFR in 2001, namely the marginalization of literature teaching, and inspired by the inclusion of literature in the 2018 Companion. It proposes ways to move away from a pure language-based approach to using literature by providing a model for developing literary literacy in the learner. It outlines four basic literary competences, defines each, and illustrates how they can be both used in class and related to the new CEFR descriptors and existing levels.
Impact of preoperative fractional flow reserve on arterial bypass graft anastomotic function: the IMPAG trial
Authors: Glineur David , Grau Juan B , Etienne Pierre-Yves , Benedetto Umberto , Fortier Jacqueline H , Papadatos Spiridon , Laruelle Christophe , Pieters Denis , El Khoury Elie , Blouard Philippe , Timmermans Patrick , Ruel Marc , Chong Aun-Yeong , So Derek , Chan Vincent , Rubens Fraser , Gaudino Mario Fl 
Published: May 2019

Abstract

Aims
Visual estimation is the most commonly used method to evaluate the degree of coronary artery stenosis prior to coronary artery bypass grafting. In interventional cardiology, the use of fractional flow reserve (FFR) to guide revascularization decisions has become routine. We investigated whether the preoperative FFR measurement of coronary lesions is associated with anastomosis function 6 months after surgical revascularization using a multiarterial grafting strategy.

Methods and results
In this prospective double-blind study, 67 patients were enrolled from two institutions in Europe and Canada. From these patients, 199 coronary lesions were assessed visually and with FFR at the time of the preoperative angiogram. All patients received coronary revascularization using multiple arterial grafts. A post-operative 6-month angiogram was performed to assess anastomosis functionality using a described angiographic method. The primary outcome was the association between preoperative FFR values and anastomosis function 6 months after surgery. Preoperative FFR was significantly associated with 6-months anastomotic function for all conduits and for all targets (P  &lt;  0.001). An FFR value of ≤0.78 was associated with an anastomotic occlusion rate of 3%.

Conclusion
We found a significant association between the preoperative FFR measurement of the target vessel and the anastomotic functionality at 6 months, with a cut-off of 0.78. Integration of FFR measurement into the preoperative diagnostic workup before multiarterial coronary surgical revascularization leads to improved anastomotic graft function.

Clinical Trials. gov Identifier
NCT02527044.