bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal-invasive Krebstherapien
Authors: Kovács Attila 
Published: March 2019

ZusammenfassungMinimal-invasive Eingriffe erweitern wesentlich das therapeutische Spektrum in der Onkologie und eröffnen neue Dimensionen, was die Überlebensraten, aber auch die Therapieverträglichkeit und Patientenfreundlichkeit betrifft. Viele interdisziplinäre Behandlungskonzepte haben sich unter dem Einfluss minimal-invasiver Verfahren entscheidend verändert, und dieser Prozess ist noch nicht abgeschlossen. Die rasante Entwicklung minimal-invasiver Therapien lässt kurz-, mittel- und langfristig auf neue Therapiekonzepte hoffen. Bildgesteuerte Hybrid-Technologien ergänzen zunehmend und ersetzen teilweise klassische Operationen. Im neu angebrochenen Zeitalter der Immuno-Onkologie ist die interdisziplinäre Zusammenarbeit und die Konzentration auf individualisierte und patientennahe Therapien essentiell. Man kann Patienten wie Therapeuten nur ermutigen, mehr die radiologisch-interventionelle Expertise bezüglich minimal-invasiver Therapien zu nutzen.
Ectopia Cordis Associated with Pentalogy of Cantrell—A Case Report
Authors: Madi José Mauro , Festugatto José Roberto , Rizzon Matheus , Agostini Ana Paula , Araújo Breno Fauth de , Garcia Rosa Maria Rahmi 
Published: March 2019

AbstractPentalogy of Cantrell (PC) is a rare congenital anomaly characterized by changes in the mesodermal median structures and congenital heart disease, often with a poor prognosis. In 1958, Cantrell et al2 defined the full spectrum of the syndrome with the following anomalies: defects of the anterior diaphragm, of the lower part of the sternum, of the supraumbilical region and the abdominal wall, of the diaphragmatic pericardium, and various intracardiac congenital abnormalities. The present report describes a case of ectopia cordis associated with PC and the importance of the participation of a multidisciplinary team in the treatment of this condition.
Revision of a Press Fit Biological Fixation Stem Fracture in a Dog
Authors: Petazzoni Massimo , De Giacinto Elena , Marcellin-Little Denis , Kowaleski Michael 
Published: March 2019

AbstractThis report describes a clinical case of a press fit biological fixation femoral implant neck fracture (fatigue failure) and its revisions in a dog. A total hip arthroplasty revision was performed. The stem was replaced with a bigger one through a V-shape osteotomy of the proximal–lateral aspect of the femur. Stabilization was accomplished using a locking plate and two over-the-plate cerclage wires. Subsidence of the femoral stem occurred following revision and was revised with a second revision in which a collared stem was used. Two revision surgeries were necessary to have a stable functional prosthesis with successful bone integration at 7 months postoperative revaluation. Major errors encountered in this case were placement of an undersized stem and an inadequate femoral canal stability/press-fit. Fracture of a BFX femoral stem neck has not been previously reported.
Comparative characterization of putative chitin deacetylases from Tetranychus cinnabarinus
Authors: Xiangshun An , Qiang Zhong , Shuyang Deng , Xiao Hu , Bu Chunya 
Published: March 2019

ABSTRACT
Considering the challenges of controlling carmine spider mite and protecting pollinators, chitin deacetylase genes (TecCDA1 and TecCDA2) of spider mite were characterized as group I, and were expressed in stage-specific pattern, which imply their role during development. The differences in sequences and structures between T. cinnabarinus and honeybee CDAs offer possibilities to design new selective pesticides protecting pollinator honeybees.
Molecular and Cytogenetic Education in Hematopathology Fellowship
Authors: Soma Lorinda A , Kovach Alexandra E , Siddon Alexa J , Beck Rose , Gibson Sarah E , Swerdlow Steven H , Kim Annette S , Wu David , Jones Dan , Cook James R , Prakash Sonam , Rosado Flavia , Crane Genevieve , Bradley Kyle , Weinberg Olga K , Sargent Rachel L 
Published: March 2019

Abstract

Objectives
Given the increased complexity of molecular and cytogenetic testing (MOL-CG), the Society for Hematopathology Education Committee (SH-EC) was interested in determining what the current expectations are for MOL-CG education in hematopathology (HP) fellowship training.

Methods
The SH-EC sent a questionnaire to HP fellowship program directors (HP-PDs) covering MOL-CG training curricula, test menus, faculty background, teaching, and sign-out roles. These findings were explored via a panel-based discussion at the 2018 SH-EC meeting for HP-PDs.

Results
HP fellows are expected to understand basic principles, nomenclature, and indications for and limitations of testing. Interpretation of common assays is within that scope, but not necessarily proficiency in technical troubleshooting of testing or analysis of complex raw data.

Conclusions
The consensus was that HP fellows should understand the components of MOL-CG testing necessary to incorporate those results into an accurate, clinically relevant, and integrated HP report.
Cancer Survivorship and Subclinical Myocardial Damage
Authors: Florido Roberta , Lee Alexandra K , McEvoy John W , Hoogeveen Ron C , Koton Silvia , Vitolins Mara Z , Shenoy Chetan , Russell Stuart D , Blumenthal Roger S , Ndumele Chiadi E , Ballantyne Christie M , Joshu Corinne E , Platz Elizabeth A , Selvin Elizabeth 
Published: March 2019

Abstract
Cancer survivors might have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and a high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT) test results. We included 3,512 participants of the Atherosclerosis Risk in Communities Study who attended visit 5 (2011–2013) and were free of CVD (coronary heart disease, heart failure, or stroke). We used multivariate logistic regression to evaluate the cross-sectional associations of survivorship from any, non-sex-related, and sex-related cancers (e.g., breast, prostate) with elevated hs-cTnT (≥14 ng/L). Of 3,512 participants (mean age, 76 years; 62% women; 21% black), 19% were cancer survivors. Cancer survivors had significantly higher odds of elevated hs-cTnT (OR = 1.26, 95% CI: 1.03, 1.53). Results were similar for survivors of non-sex-related and colorectal cancers, but there was no association between survivorship from breast and prostate cancers and elevated hs-cTnT. Results were similar after additional adjustments for CVD risk factors. Survivors of some cancers might be more likely to have elevated hs-cTnT than persons without prior cancer. The excess burden of subclinical myocardial damage in this population might not be fully explained by traditional CVD risk factors.
Neural networks with circular filters enable data efficient inference of sequence motifs
Authors: Blum Christopher F , Kollmann Markus 
Published: March 2019

Abstract

Motivation
Nucleic acids and proteins often have localized sequence motifs that enable highly specific interactions. Due to the biological relevance of sequence motifs, numerous inference methods have been developed. Recently, convolutional neural networks (CNNs) have achieved state of the art performance. These methods were able to learn transcription factor binding sites from ChIP-seq data, resulting in accurate predictions on test data. However, CNNs typically distribute learned motifs across multiple filters, making them difficult to interpret. Furthermore, networks trained on small datasets often do not generalize well to new sequences.

Results
Here we present circular filters, a novel convolutional architecture, that convolves sequences with circularly permutated variants of the same filter. We motivate circular filters by the observation that CNNs frequently learn filters that correspond to shifted and truncated variants of the true motif. Circular filters enable learning of full-length motifs and allow easy interpretation of the learned filters. We show that circular filters improve motif inference performance over a wide range of hyperparameters as well as sequence length. Furthermore, we show that CNNs with circular filters in most cases outperform conventional CNNs at inferring DNA binding sites from ChIP-seq data.

Availability and implementation
Code is available at https://github.com/christopherblum.

Supplementary information
Supplementary data are available at Bioinformatics online.
Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Authors: Halu Arda , Liu Shikang , Baek Seung Han , Hobbs Brian D , Hunninghake Gary M , Cho Michael H , Silverman Edwin K , Sharma Amitabh 
Published: March 2019

Abstract
Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are two pathologically distinct chronic lung diseases that are associated with cigarette smoking. Genetic studies have identified shared loci for COPD and IPF, including several loci with opposite directions of effect. The existence of additional shared genetic loci, as well as potential shared pathobiological mechanisms between the two diseases at the molecular level, remains to be explored. Taking a network-based approach, we built disease modules for COPD and IPF using genome-wide association studies-implicated genes. The two disease modules displayed strong disease signals in an independent gene expression data set of COPD and IPF lung tissue and showed statistically significant overlap and network proximity, sharing 19 genes, including ARHGAP12 and BCHE. To uncover pathways at the intersection of COPD and IPF, we developed a metric, NetPathScore, which prioritizes the pathways of a disease by their network overlap with another disease. Applying NetPathScore to the COPD and IPF disease modules enabled the determination of concordant and discordant pathways between these diseases. Concordant pathways between COPD and IPF included extracellular matrix remodeling, Mitogen-activated protein kinase (MAPK) signaling and ALK pathways, whereas discordant pathways included advanced glycosylation end product receptor signaling and telomere maintenance and extension pathways. Overall, our findings reveal shared molecular interaction regions between COPD and IPF and shed light on the congruent and incongruent biological processes lying at the intersection of these two complex diseases.
Driving status, travel modes and accelerometer-assessed physical activity in younger, middle-aged and older adults: a prospective study of 90 810 UK Biobank participants
Authors: Hajna Samantha , White Tom , Panter Jenna , Brage Søren , Wijndaele Katrien , Woodcock James , Ogilvie David , Imamura Fumiaki , Griffin Simon J 
Published: March 2019

AbstractBackgroundAssociations between driving and physical-activity (PA) intensities are unclear, particularly among older adults. We estimated prospective associations of travel modes with total PA, sedentary time (ST), light-intensity PA (LPA), and moderate-to-vigorous intensity PA (MVPA) among adults aged 39–70 years.MethodsWe studied 90 810 UK Biobank participants (56.1 ± 7.8 years). Driving status, specific travel modes (non-work travel; commuting to/from work) and covariates were assessed by questionnaire (2006–10). PA was assessed over 7 days by wrist-worn accelerometers (2013–15). We estimated associations using overall and age-stratified multivariable linear-regression models.ResultsDrivers accumulated 1.4% more total PA (95% confidence interval: 0.9, 1.9), 11.2 min/day less ST (–12.9, –9.5), 12.2 min/day more LPA (11.0, 13.3) and 0.9 min/day less MVPA (–1.6, –0.2) than non-drivers. Compared with car/motor-vehicle users, cyclists and walkers had the most optimal activity profiles followed by mixed-mode users (e.g. for non-work travel, cyclists: 10.7% more total PA, 9.0, 12.4; 20.5 min/day less ST, –26.0, –15.0; 14.5 min/day more MVPA, 12.0, 17.2; walkers: 4.2% more total PA, 3.5, 5.0; 7.5 min/day less ST –10.2, –4.9; 10.1 min/day more MVPA, 8.9, 11.3; mixed-mode users: 2.3% more total PA, 1.9, 2.7; 3.4 min/day less ST –4.8, –2.1; 4.9 min/day more MVPA, 4.3, 5.5). Some associations varied by age (p interaction &lt; 0.05), but these differences appeared small.ConclusionsAssessing specific travel modes rather than driving status alone may better capture variations in activity. Walking, cycling and, to a lesser degree, mixed-mode use are associated with more optimal activity profiles in adults of all ages.
Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood
Authors: Crump Casey , Friberg Danielle , Li Xinjun , Sundquist Jan , Sundquist Kristina 
Published: March 2019

Abstract

Background
Preterm birth (gestational age &lt;37 weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but has seldom been examined in relation to sleep disorders. We conducted the first population-based study of preterm birth in relation to sleep-disordered breathing (SDB) from childhood into mid-adulthood.

Methods
A national cohort study was conducted of all 4 186 615 singleton live births in Sweden during 1973–2014, who were followed for SDB ascertained from nationwide inpatient and outpatient diagnoses through 2015 (maximum age 43 years). Cox regression was used to examine gestational age at birth in relation to SDB while adjusting for other perinatal and maternal factors, and co-sibling analyses assessed for potential confounding by unmeasured shared familial factors.

Results
There were 171 100 (4.1%) persons diagnosed with SDB in 86.0 million person-years of follow-up. Preterm birth was associated with increased risk of SDB from childhood into mid-adulthood, relative to full-term birth (39–41 weeks) [adjusted hazard ratio (aHR), ages 0–43 years: 1.43; 95% confidence interval (CI), 1.40, 1.46; P &lt;0.001; ages 30–43 years: 1.40; 95% CI, 1.34, 1.47; P &lt;0.001]. Persons born extremely preterm (&lt;28 weeks) had more than 2-fold risks (aHR, ages 0–43 years: 2.63; 95% CI, 2.41, 2.87; P &lt;0.001; ages 30–43 years: 2.22; 95% CI, 1.64, 3.01; P &lt;0.001). These associations affected both males and females, but accounted for more SDB cases among males (additive interaction, P = 0.003). Co-sibling analyses suggested that these findings were only partly due to shared genetic or environmental factors in families.

Conclusions
Preterm-born children and adults need long-term follow-up for anticipatory screening and potential treatment of SDB.
Analysis of finite element methods for vector Laplacians on surfaces
Authors: Hansbo Peter , Larson Mats G , Larsson Karl 
Published: March 2019

Abstract
We develop a finite element method for the vector Laplacian based on the covariant derivative of tangential vector fields on surfaces embedded in ${\mathbb{R}}^3$. Closely related operators arise in models of flow on surfaces as well as elastic membranes and shells. The method is based on standard continuous parametric Lagrange elements that describe a ${\mathbb{R}}^3$ vector field on the surface, and the tangent condition is weakly enforced using a penalization term. We derive error estimates that take into account the approximation of both the geometry of the surface and the solution to the partial differential equation. In particular, we note that to achieve optimal order error estimates, in both energy and $L^2$ norms, the normal approximation used in the penalization term must be of the same order as the approximation of the solution. This can be fulfilled either by using an improved normal in the penalization term, or by increasing the order of the geometry approximation. We also present numerical results using higher-order finite elements that verify our theoretical findings.
Age-Related Differences in Past or Present Hepatitis C Virus Infection Among People Who Inject Drugs: National Human Immunodeficiency Virus Behavioral Surveillance, 8 US Cities, 2015
Authors: Abara Winston E , Trujillo Lindsay , Broz Dita , Finlayson Teresa , Teshale Eyasu , Paz-Bailey Gabriela , Glick Sara , Al-Tayyib Alia A , Robinson William T , Masiello-Schuette Stephanie , Sey Ekow K , Anderson Bridget J , Poe Jonathon , Braunstein Sarah 
Published: March 2019

Abstract

Background
Historically, older people who inject drugs (PWID) have had the highest hepatitis C virus (HCV) burden; however, young PWID now account for recent increases. We assessed factors associated with past or present HCV infection (HCV antibody [anti-HCV] positive) among young (≤35 years) and older (>35 years) PWID.

Methods
We calculated adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) to examine sociodemographic and past 12-month injection behaviors associated with HCV infection.

Results
Of 4094 PWID, 55.2% were anti-HCV positive. Among young PWID, anti-HCV prevalence was 42.1% and associated with ≤high school diploma/General Education Development diploma (GED) (aPR, 1.17 [95% CI, 1.03–1.33]), receptive syringe sharing (aPR, 1.37 [95% CI, 1.21–1.56]), sharing injection equipment (aPR, 1.16 [95% CI, 1.01–1.35]), arrest history (aPR, 1.14 [95% CI, 1.02–1.29]), and injecting speedball (aPR, 1.37 [95% CI, 1.16–1.61]). Among older PWID, anti-HCV prevalence was 62.2% and associated with ≤high school diploma/GED (aPR, 1.08 [95% CI, 1.02–1.15]), sharing injection equipment (aPR, 1.08 [95% CI, 1.02–1.15]), high injection frequency (aPR, 1.16 [95% CI, 1.01–1.34]), and injecting speedball (aPR, 1.09 [95% CI, 1.01–1.16]).

Conclusions
Anti-HCV prevalence is high among PWID and varies with age. Scaling up direct-acting antiviral treatment, syringe service programs, and medication-assisted therapy is critical to mitigating transmission risk and infection burden.
Social determinants of health in mental health care and research: a case for greater inclusion
Authors: Deferio Joseph J , Breitinger Scott , Khullar Dhruv , Sheth Amit , Pathak Jyotishman 
Published: March 2019

AbstractSocial determinants of health (SDOH) are known to influence mental health outcomes, which are independent risk factors for poor health status and physical illness. Currently, however, existing SDOH data collection methods are ad hoc and inadequate, and SDOH data are not systematically included in clinical research or used to inform patient care. Social contextual data are rarely captured prospectively in a structured and comprehensive manner, leaving large knowledge gaps. Extraction methods are now being developed to facilitate the collection, standardization, and integration of SDOH data into electronic health records. If successful, these efforts may have implications for health equity, such as reducing disparities in access and outcomes. Broader use of surveys, natural language processing, and machine learning methods to harness SDOH may help researchers and clinical teams reduce barriers to mental health care.
Development of a Quick Knockdown Test for Diagnosing Resistance to Phosphine in Sitophilus oryzae (Coleoptera: Curculionidae), a Major Pest of Stored Products
Authors: Nayak Manoj K , Kaur Ramandeep , Jagadeesan Rajeswaran , Pavic Hervoika , Phillips Thomas W , Daglish Gregory J 
Published: March 2019

AbstractA key component in the management of resistance to fumigant phosphine in stored products pests is their early detection and implementation of control strategies. Currently, resistance testing involves exposing adults to a specific discriminating concentration over a fixed time period (20–48 h). Although it is widely adopted, this test takes significant time for assay preparation (up to 4 wk) as well as diagnosis (1–2 wk). To address these lacunae, we have established a ‘quick knockdown test’ using a key grain insect pest, rice weevil, Sitophilus oryzae (L.). Susceptible, weakly and strongly phosphine-resistant reference strains were exposed to a threshold concentration of phosphine over short exposure periods (min to h). The time to knockdown (KT) responses to phosphine were characterized at 2 (1,440 ppm) and 5 mg/liter (3,600 ppm). The time to 99.9% KT (KT99.9) at 2 mg/liter was 12.52 min for the susceptible adults, compared with 167.9 and 1,510 min in the case of weakly and strongly resistant phenotypes, respectively. As anticipated, increasing the concentration of phosphine to 5 mg/liter halved the KT99.9 (81.57 min) to separate weakly and strongly resistant populations than it was required at 2 mg/liter. We validated the KT99.9 value for the 5 mg/liter against field-derived populations of S. oryzae. The results were aligned with the existing Food and Agriculture Organization approach, confirming that the proposed ‘quick test’ is a reliable tool to rapidly diagnose resistance in this species.
New candidate loci and marker genes on chromosome 7 for improved chilling tolerance in sorghum
Authors: Moghimi Naghmeh , Desai Jigar S , Bheemanahalli Raju , Impa Somayanda M , Vennapusa Amaranatha Reddy , Sebela David , Perumal Ramasamy , Doherty Colleen J , Jagadish S V Krishna 
Published: March 2019

Abstract
Sorghum is often exposed to suboptimal low temperature stress under field conditions, particularly at the seedling establishment stage. Enhancing chilling tolerance will facilitate earlier planting and so minimize the negative impacts of other stresses experienced at later growth stages. Genome-wide association mapping was performed on a sorghum association panel grown under control (30/20 °C; day/night) and chilling (20/10 °C) conditions. Genomic regions on chromosome 7, controlling the emergence index and seedling (root and shoot) vigor, were associated with increased chilling tolerance but they did not co-localize with undesirable tannin content quantitative trait loci (QTLs). Shoot and root samples from highly contrasting haplotype pairs expressing differential responses to chilling stress were used to identify candidate genes. Three candidate genes (an alpha/beta hydrolase domain protein, a DnaJ/Hsp40 motif-containing protein, and a YTH domain-containing RNA-binding protein) were expressed at significantly higher levels under chilling stress in the tolerant haplotype compared with the sensitive haplotype and BTx623. Moreover, two CBF/DREB1A transcription factors on chromosome 2 showed a divergent response to chilling in the contrasting haplotypes. These studies identify haplotype differences on chromosome 7 that modulate chilling tolerance by either regulating CBF or feeding back into this signaling pathway. We have identified new candidate genes that will be useful markers in ongoing efforts to develop tannin-free chilling-tolerant sorghum hybrids.
Alternative Paths, Phrase Expansion, and the Music of Felix Mendelssohn
Authors: Jarvis Brian Edward , Peterson John 
Published: March 2019

AbstractWilliam Rothstein’s seminal work on phrase rhythm has been foundational for scholars who study phrase expansion using Schenkerian principles, such as David Beach, Charles Burkhart, Joseph Kraus, and Samuel Ng. Other scholars consider phrase expansion from the perspective of William Caplin’s form-functional theory, such as Janet Schmalfeldt and Steven Vande Moortele. Both groups tend to emphasize structural concerns. Recent theories of musical meaning, however, challenge analysts to consider phrase expansions through an expressive lens. This article engages with that challenge using the metaphor of musical motion, a concept that is informally present in numerous analytical writings but was formalized in work on conceptual metaphors by Steve Larson and Mark Johnson. In particular, we introduce a category of expansion techniques called “alternative paths” in which a phrase deviates from its expected course toward a goal via the addition of new material. By defining how the new material is initiated and concluded, alternative paths provide a more nuanced view of passages that might otherwise be described by the more generic terms “parenthesis,” “interpolation,” or “purple patch.” We use Felix Mendelssohn’s works to demonstrate the effectiveness and flexibility of our approach, though the theory of alternative paths is by no means limited to that repertoire.