bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel screening instrument for the assessment of autism in German language: validation of the German version of the RAADS-R, the RADS-R
Authors: Rausch Jördis , Fangmeier Thomas , Falter-Wagner Christine M. , Ackermann Helene , Espelöer Julia , Hölzel Lars P. , Riedel Andreas , Ritvo Ariella , Vogeley Kai , van Elst Ludger Tebartz 
Published: October 2024

AbstractThe Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) demonstrated excellent results in its original study, with a sensitivity of 97% and a specificity of 100% (Ritvo et al. in J Autism Dev Disord 41:1076–1089, 2011). As a result, it was included in the National Institute for Health and Care Excellence (NICE) guidelines (Recommendations | Autism spectrum disorder in adults: diagnosis and management | Guidance | NICE, 2022). The questionnaire includes 80 questions across four subcategories (language, social relatedness, circumscribed interests, sensory motor). So far, the subcategory sensory motor has not been addressed in most available instruments, despite being part of the diagnostic criteria specified in DSM-5 (Falkai et al., in Diagnostisches Und Statistisches Manual Psychischer Störungen DSM-5. Hogrefe, 2015) and ICD-11 (ICD-11 for Mortality and Morbidity Statistics, 2022). In our validation study, we tested a translated German version of the questionnaire in 299 individuals (110 persons with ASD according to ICD-10 F84.0, F84.5, 64 persons with an primary mental disorders (PMD), 125 persons with no disorders). To enhance the practical use of the instrument in clinical everyday practice, the questionnaire was completed by the participants without the presence of a clinician—unlike the original study. Psychiatric diagnoses were established following the highest standards, and psychometric properties were calculated using established protocols. The German version of the RADS-R yielded very good results, with a high sensitivity of 92.5% and a high specificity of 93.6%. The area under the curve (AUC = 0.976), indicates a high quality and discriminatory power of RADS-R. Furthermore, the ROC curve analysis showed that the optimal threshold to distinguish between the ASD and non-ASD groups in the German version of the RAADS-R is a score of 81. In comparison to the RADS-R, the co-administered instruments Social Responsiveness Scale (SRS), Autism Spectrum Quotient (AQ), and Empathy Quotient (EQ) each showed slightly better specificity but worse sensitivity in this sample.The study included individuals already diagnosed with ASD according to ICD-10 (F84.0, F84.5), with or without an primary mental disorders, preventing us from identifying the influence of comorbidities on the RADS-R results. In addition, a self-report questionnaire has generally only limited objectivity and may allow for false representation of the symptoms. The RADS-R compares well with other questionnaires and can provide valuable additional information. It could turn out to be a helpful diagnostic tool for patients in Germany. We propose naming the German version RADS-R (Ritvo Autism Diagnostic Scale – rRevised) to reflect the change in terminology.
The MorbidGenes panel: a monthly updated list of diagnostically relevant rare disease genes derived from diverse sources
Authors: Jauss Robin-Tobias , Popp Bernt , Bachmann Joachim , Abou Jamra Rami , Platzer Konrad 
Published: October 2024

AbstractPurpose: With exome sequencing now standard, diagnostic labs are in need of a, in principle, to-the-day-accurate list of genes associated with rare diseases. Manual curation efforts are slow and often disease specific, while efforts relying on single sources are too inaccurate and may result in false-positive or false-negative genes. Methods: We established the MorbidGenes panel based on a list of publicly available databases: OMIM, PanelApp, SysNDD, ClinVar, HGMD and GenCC. A simple logic allows inclusion of genes that are supported by at least one of these sources, providing a list of all genes with diagnostic relevance. Results: The panel is freely available at https://morbidgenes.uni-leipzig.de and currently includes 5037 genes (as of October 2024) with minimally sufficient evidence on disease causality to classify them as diagnostically relevant. Conclusion: The MorbidGenes panel is an open and comprehensive overview of diagnostically relevant rare disease genes based on a diverse set of resources. The panel is updated monthly to keep up with the ever increasing number of rare disease genes.
Rapid remote volcanic ashfall impact assessment for the 2022 eruption of Hunga volcano, Tonga: a bespoke approach and lessons identified
Authors: Weir Alana M. , Williams James H. , Wilson Thomas M. , Hayes Josh L. , Stewart Carol , Leonard Graham S. , Magill Christina , Jenkins Susanna F. , Williams Shaun , Craig Heather M. , Kula Taaniela , Fraser Stuart , Pomonis Antonios , Gunasekera Rashmin , Daniell James E. , Coultas Emma 
Published: October 2024

AbstractWhen disasters occur, rapid impact assessments are required to prioritise response actions, support in-country efforts and inform the mobilisation of aid. The 15 January 2022 eruption of Hunga volcano, Tonga, and the resulting atmospheric shockwave, ashfall, underwater mass disturbance and tsunami, caused substantial impacts across the Kingdom of Tonga. Volcanic impacts on the scale observed after the eruption are rare, necessitating a reliance on international advice and assistance. The situation was complicated by the loss of Tonga’s international submarine fibreoptic cable (causing a complete loss of communications for approximately 20 days) along with border closures due to the COVID-19 pandemic. A need emerged for a rapid remote volcanic impact assessment and provision of specialist advice to help inform the response of international partners. Here we present a novel methodology for conducting rapid remote volcanic ashfall impact assessments, conducted over a 10-day period following the eruption. We used three different hazard models for ashfall thickness across the main island of Tongatapu and available asset information and vulnerability functions for buildings, agriculture, electricity networks, water supply and roads, to provide initial estimates of losses due to ashfall from the 15 January eruption. For buildings, we estimated losses both as total losses and as percentages of the total replacement cost of buildings on Tongatapu. For agriculture, we made probabilistic estimates of production losses for three different crop classes. For ashfall clean-up, we estimated ranges of ashfall volumes requiring clean-up from road surfaces and roofs. For water supply, electricity networks and roads, our analysis was limited to assessing the exposure of important assets to ashfall, as we had insufficient information on system configurations to take the analysis further. Key constraints on our analysis were the limited nature of critical infrastructure asset inventories and the lack of volcanic vulnerability models for tropical regions including Pacific Island nations. Key steps towards iteratively improving rapid remote impact assessments will include developing vulnerability functions for tropical environments as well as ground-truthing estimated losses from remote approaches against in-person impact assessment campaigns.
Cholecystectomy with the Hugo™ robotic-assisted surgery system: the first general surgery clinical study in Korea
Authors: Kwon Wooil , Jang Jin-Young , Jeong Chang Wook , Anselme Sylvain , Pradella Fabio , Woods Jacklyn 
Published: October 2024

Abstract
Background
The Hugo™ Robotic-Assisted Surgery (RAS) System is an emergent device in the robotic surgery field. This study aims to describe the first general surgery-focused clinical study in Korea using the novel Hugo™ RAS System.

Methods
This study was a prospective, single-center, single-arm, confirmatory clinical study conducted at Seoul National University Hospital where 20 cholecystectomies were performed. To evaluate the safety and performance of the Hugo™ RAS System the incidence of conversion to laparoscopy or open surgery, major complication (Clavien-Dindo Grade ≥ III) rate, overall complication rate, readmission rate, and reoperation rate were evaluated. All parameters were assessed within 30 days post-procedure. Any device deficiencies encountered during our initial experience and device data such as setup, console, and operative times were also reported.

Results
We confirmed that our trial achieved the primary objective with a success rate of at least 95%. This was accomplished with no conversions to other types of surgery due to serious system malfunction and with only one major complication within 24 h post-procedure. The 20 consecutively enrolled patients had a median age and BMI of 58 years old and 23.9 kg/m2, respectively. The major complication rate was 10% (2/20 patients), the overall complication rate was 15% (3/20 patients), the readmission rate was 15% (3/20 patients), and the reoperation rate was 0% (0/20 patients). None of the complications were definitively device related. The median setup, console, and operative times were 16, 17, and 55 min, respectively. The device deficiency rate was 15% (3/20 patients), but all device deficiencies were minor, occurred before the first incision, and did not present a risk to the patient.

Conclusion
Based on our initial experience with the Hugo™ RAS System, cholecystectomy is feasible and safe. This trial is registered with ClinicalTrials.gov (NCT05715827).
Obinutuzumab as a viable therapeutic strategy in rituximab-refractory childhood frequently relapsing, steroid-dependent nephrotic syndrome that relapsed during B-cell depletion
Authors: Chan Eugene Yu-hin , Lin Kyle Ying-kit , Yap Desmond Yat-hin , Ma Alison Lap-tak 
Published: October 2024

Abstract
A subgroup of children with frequently-relapsing, steroid-dependent nephrotic syndrome relapse during B-cell depletion after rituximab. A 15-year-old boy with focal segmental glomerulosclerosis became rituximab-refractory after 5 courses of treatments, with a relapse-free period shortened to 1 month. Circulating total and memory B-cells were undetectable at the time of relapse. A single infusion of obinutuzumab sustained relapse-free remission up to the last follow-up at 18 months. There was persistent hypogammaglobulinemia but no infection was observed. Obinutuzumab may be a viable option for attaining long-term remission with reasonable side effect profiles in patients who relapse during B-cell depletion after rituximab.
Photobiomodulation therapy for mitigating severity of radiodermatitis in cancer patients undergoing radiotherapy: a scoping review
Authors: Rao Devika , Dsouza Cliva Neha , Prabhu Smitha S , Kumar Praveen , Prabhu Vijendra 
Published: October 2024

Abstract
Purpose
Radiodermatitis (RD) is an adverse effect of radiation therapy. RD can negatively impact quality of life and can also hinder treatment in cancer patients. Photobiomodulation therapy (PBMT) has the potential to treat RD at the cellular level, and it is more promising compared to other therapy alternatives. This review aims to examine the effectiveness of PBMT for the treatment and management of RD in cancer patients undergoing radiation therapy.

Methods
The methodology followed for the review was based on the framework proposed by Arksey and O’Malley, and the extensions by Levac et al. This involved a literature search in Scopus, PubMed, Embase, and Cochrane without any time limit, for original articles on the basis of the inclusion criteria, i.e., studies focusing on the effectiveness of PBMT on RD in cancer patients undergoing radiation therapy as an anticancer treatment. The review has been reported on the basis of the PRISMA-ScR checklist.

Results
A total of 14 studies were reviewed, of which only 2 (14.28%) studies reported no significant effect of PBMT on RD; the remaining studies reported positive outcomes (85.71%) with no adverse effects. Among studies with positive outcomes, PBMT has been shown to be beneficial in reducing the severity of RD. Furthermore, PBMT application has been studied as a preventive measure (35.71%), treatment and management (50%), and for both the prevention and cure of RD (14.29%).

Conclusion
Overall, PBMT can be considered a reliable and effective treatment modality for reducing the severity of RD. However detailed studies related to the long-term effects of PBMT, its effect on pain intensity and quality of life (QoL) will aid in better assessment of the technique. More clinical trials with a broader sample size could also aid in fine-tuning the efficacy of PBMT treatment modalities.
How do patients with head and neck cancer and low skeletal muscle mass experience cisplatin-based chemoradiotherapy? A qualitative study
Authors: Schaeffers Anouk W. M. A. , van Beers Maartje A. , Devriese Lot A. , Klomp F. W. José , Westerink - van den Brink Chantal F. M. , Smid Ernst J. , de Bree Remco , Speksnijder Caroline M. 
Published: October 2024

Abstract
Background
Patients with head and neck squamous cell carcinoma (HNSCC) face several physical, emotional, and psychological challenges throughout treatment. Cisplatin-based chemoradiotherapy (CRT) is an effective but toxic treatment, with an increased risk for toxicities in patients with low skeletal muscle mass (SMM). Consequently, these patients are anticipated to experience greater treatment-related difficulties. We aimed to explore the experiences of patients with HNSCC and low SMM regarding cisplatin-based CRT.

Methods
A descriptive qualitative study was conducted, interviewing seven patients 3 months after CRT using a topic guide. Thematic analysis of semi-structured interviews was conducted, to create a multi-dimensional understanding of patients’ experiences during and after cisplatin-based CRT.

Results
Prior to CRT themes included pre-treatment information, expectations towards treatment and trial, psychosocial circumstances, and supporting network. During CRT themes included toxicities, psychosocial impact, and supporting network. After CRT themes included reflection on period during CRT, psychosocial circumstances, informal support from networks and healthcare workers, and ongoing toxicities.

Conclusion
Most patients experience cisplatin-based CRT as a life-changing and distressing life event but cope through various strategies and supporting networks. Tailored counseling, ideally with on-demand consultations, is recommended. No differences were noted in patients’ perceptions of their cisplatin regimen.
The “greywacke problem” explored in the Neoproterozoic of Saxo-Thuringia: new insights into sediment composition and metamorphic overprint
Authors: Kühnemann Victoria , Meinhold Guido , Schulz Bernhard , Gilbricht Sabine , Weber Sebastian , Wemmer Klaus 
Published: October 2024

Abstract
Greywackes make up a substantial part of the Cadomian basement of Saxo-Thuringia. Here, their classification as greywackes and the timing of metamorphic overprint are re-evaluated using a multi-method approach. Immature monotonous greywacke sequences from the Lausitz (Lausitz Block) and Leipzig groups (North Saxon Anticline), as well as from the eastern Thuringian Basin and parts of the Weesenstein Group (Elbe Zone) probably belong to a coherent unit, based on microscopic investigations supported by SEM Automated Mineralogy analyses and point counting data. However, due to the low matrix content (< 15%), the sedimentary rocks are more likely classified as lithic sandstones. The heterogeneous composition and in particular the highly mature character of the Clanzschwitz Group (North Saxon Anticline) and parts of the Weesenstein Group (Seidewitz Formation) suggest a younger, Late Cambrian to Early Ordovician sedimentation age. Typically, the metamorphic overprint of the “greywacke units” is very weak. Previous assumptions of Cadomian contact metamorphism triggered by Early Cambrian intrusions (ca. 540 Ma) could not be confirmed due to the local differences in the determined metamorphic ages. Late Cambrian to Early Ordovician (521–461 Ma) Th–U–Pb monazite ages are likely related to the tectonic transition from the collisional regime of the Cadomian orogeny to extensional processes in the course of the opening of the Rheic Ocean. Sporadic Late Ordovician (458–445 Ma) Th–U–Pb monazite and K–Ar fine-fraction ages were also obtained but the specific thermal trigger is still subject of debate. The Permo-Carboniferous metamorphic ages (314–286 Ma) indicate high-temperature metamorphism related to the post-Variscan extensional processes of Central Europe during this period. The youngest dated monazites are Jurassic in age and may have grown in association with the hydrothermal activity known from Central Europe at that time.

Graphical abstract
Methodological considerations in calculating the minimal clinically important change score for the core outcome measures index (COMI): insights from a large single-centre spine surgery registry
Authors: Cina Andrea , Vitale Jacopo , Haschtmann Daniel , Loibl Markus , Fekete Tamas F. , Kleinstück Frank , Galbusera Fabio , Jutzeler Catherine R. , Mannion Anne F. 
Published: October 2024

Abstract
Introduction
The Minimal Clinically Important Change (MCIC) is used in conjunction with Patient-Reported Outcome Measures (PROMs) to determine the clinical relevance of changes in health status. MCIC measures a change within the same person or group over time. This study aims to evaluate the variability in computing MCIC for the Core Outcome Measure Index (COMI) using different methods.

Methods
Data from a spine centre in Switzerland were used to evaluate variations in MCIC for the COMI score. Distribution-based and anchor-based methods (predictive and nonpredictive) were applied. Bayesian bootstrap estimated confidence intervals.

Results
From 27,003 cases, 9821 met the inclusion criteria. Distribution-based methods yielded MCIC values from 0.4 to 1.4. Anchor-based methods showed more variability, with MCIC values from 1.5 to 4.9. Predictive anchor-based methods also provided variable MCIC values for improvement (0.3–2.4), with high sensitivity and specificity.

Discussion
MCIC calculation methods produce varying values, emphasizing careful method selection. Distribution-based methods likely measure minimal detectable change, while non-predictive anchor-based methods can yield high MCIC values due to group averaging. Predictive anchor-based methods offer more stable and clinically relevant MCIC values for improvement but are affected by prevalence and reliability corrections.
Potential for 50% Mechanical Strength Decline in Sandstone Reservoirs Due to Salt Precipitation and CO2–Brine Interactions During Carbon Sequestration
Authors: Nooraiepour Mohammad , Polański Krzysztof , Masoudi Mohammad , Kuczyński Szymon , Derluyn Hannelore , Nogueira Liebert Parreiras , Bohloli Bahman , Nagy Stanislaw , Hellevang Helge 
Published: October 2024

AbstractPredictive modeling of CO2 storage sites requires a detailed understanding of physico-chemical processes and scale-up challenges. Dramatic injectivity decline may occur due to salt precipitation pore clogging in high-salinity aquifers during subsurface CO2 injection. This study aims to elucidate the impact of CO2-induced salt crystallization in the porous medium on the geomechanical properties of reservoir sandstones. As the impact of salt precipitation cannot be isolated from the precursor interactions with CO2 and acidified brine, we present a comprehensive review and discuss CO2 chemo-mechanical interactions with sandstones. Laboratory geochemical CO2–brine–rock interactions at elevated pressures and temperatures were conducted on two sandstone sets with contrasting petrophysical qualities. Interaction paths comprised treatment with (a) CO2-acidified brine and (b) supercritical injection until brine dry-out, salt crystallization, and growth. Afterward, the core samples were tested in a triaxial apparatus at varying stresses and temperatures. The elastic moduli of intact, CO2-acidified brine treated, and salt-affected sandstones were juxtaposed to elucidate the geochemical–geomechanical-coupled impacts and identify the extent of crystallization damages. The salt-affected sandstones showed a maximum of 50% reduction in Young’s and shear moduli and twice an increase in Poisson’s ratio compared to intact condition. The deterioration was notably higher for the tighter reservoir sandstones, with higher initial stiffness and lower porosity–permeability. We propose two pore- and grain-scale mechanisms to explain how salt crystallization contributes to stress localization and mechanical damage. The results highlight the potential integrity risk imposed by salt crystallization in (hyper)saline aquifers besides injectivity, signaling mechanical failure exacerbated by pressure buildup.
Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial
Authors: Nawar Nawar Naguib , Elashiry Mohamed Mohamed , El Banna Ahmed , Saber Shehabeldin Mohamed , Schäfer Edgar 
Published: October 2024

Abstract
Objectives
This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques.

Methods
For the first phase of the study, 24 teeth scheduled for orthodontic extractions were allocated into four groups according to the canal dryness protocol and the obturation technique. G1 (CLC-AHP): cold lateral compaction (CLC) with AH Plus sealer, G2 (CLC-ES-SD): CLC with Endosequence (ES) after standard canal(s) dryness (SD); G3 (SC-ES-SD): matching single-cone (SC) with ES after SD; G4 (SC-ES-PD): as G3 but after partial canal(s) dryness (PD). Teeth were extracted after one month of clinical service and examined for intracanal voids by micro-CT (2D & 3D). For the 2nd phase, another 24 teeth were allocated into four groups according to the root canal dryness protocol and the HCSBS used (ES or CeraSeal (CeS)). Teeth were extracted after one month and sectioned vertically for energy dispersive X-ray (EDX)/scanning electron microscope (SEM) examination. One-way ANOVA with Games-Howell post-hoc test and Chi-square test with multiple z-tests were used for statistical analysis.

Results
SC-PD showed the highest percentage of voids (p < 0.05). MicroCT scans as well as EDX/SEM examination showed that PD resulted in significantly larger interfacial gaps (p < 0.001) with more hydration products at the sealer/dentin interface than SD.

Conclusions
Both tested dryness protocols allowed the hydration of HCSBS and the formation of hydration products, thus standard dryness is recommended to reduce the incidence of intracanal voids.

Clinical relevance
When using the single-cone obturation technique, intentional root canal moisture negatively affects the performance of HCSBS.

Protocol Registration
http://www.clinicaltrials.gov, ID: NCT05808062.