bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer
Authors: He Weizhi , Wu Jinghua , Shi Juanjuan , Huo Yan-Miao , Dai Wentao , Geng Jing , Lu Ping , Yang Min-Wei , Fang Yuan , Wang Wei , Zhang Zhi-Gang , Habtezion Aida , Sun Yong-Wei , Xue Jing 
Published: March 2018

Abstract
Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune cells or immune cell–related signals affect pancreatic cancer stemness and development. Our previous work showed that IL22/IL22RA1 plays a vital role in acute and chronic pancreatitis progression by mediating cross-talk between immune cells and acinar cells or stellate cells, respectively. Here, we find IL22RA1 is highly but heterogeneously expressed in pancreatic cancer cells, with high expression associated with poor prognosis of patients with pancreatic cancer. The IL22RA1hi population from pancreatic cancer harbored higher stemness potential and tumorigenicity. Notably, IL22 promoted pancreatic cancer stemness via IL22RA1/STAT3 signaling, establishing the mechanism of regulation of cancer stemness by microenvironmental factors. Moreover, STAT3 was indispensable for the maintenance of IL22RA1hi cells. Overall, these findings provide a therapeutic strategy for patients with PDAC with high expression of IL22RA1.
Significance: IL22RA1/STAT3 signaling enhances stemness and tumorigenicity in pancreatic cancer. Cancer Res; 78(12); 3293–305. ©2018 AACR.
Epigenome-wide SRC-1–Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer
Authors: Ward Elspeth , Varešlija Damir , Charmsaz Sara , Fagan Ailis , Browne Alacoque L. , Cosgrove Nicola , Cocchiglia Sinéad , Purcell Siobhan P. , Hudson Lance , Das Sudipto , O'Connor Darran , O'Halloran Philip J. , Sims Andrew H. , Hill Arnold D. , Young Leonie S. 
Published: March 2018

Abstract
Purpose: Despite the clinical utility of endocrine therapies for estrogen receptor–positive (ER) breast cancer, up to 40% of patients eventually develop resistance, leading to disease progression. The molecular determinants that drive this adaptation to treatment remain poorly understood. Methylome aberrations drive cancer growth yet the functional role and mechanism of these epimutations in drug resistance are poorly elucidated.
Experimental Design: Genome-wide multi-omics sequencing approach identified a differentially methylated hub of prodifferentiation genes in endocrine resistant breast cancer patients and cell models. Clinical relevance of the functionally validated methyl-targets was assessed in a cohort of endocrine-treated human breast cancers and patient-derived ex vivo metastatic tumors.
Results: Enhanced global hypermethylation was observed in endocrine treatment resistant cells and patient metastasis relative to sensitive parent cells and matched primary breast tumor, respectively. Using paired methylation and transcriptional profiles, we found that SRC-1–dependent alterations in endocrine resistance lead to aberrant hypermethylation that resulted in reduced expression of a set of differentiation genes. Analysis of ER-positive endocrine-treated human breast tumors (n = 669) demonstrated that low expression of this prodifferentiation gene set significantly associated with poor clinical outcome (P = 0.00009). We demonstrate that the reactivation of these genes in vitro and ex vivo reverses the aggressive phenotype.
Conclusions: Our work demonstrates that SRC-1-dependent epigenetic remodeling is a ’high level’ regulator of the poorly differentiated state in ER-positive breast cancer. Collectively these data revealed an epigenetic reprograming pathway, whereby concerted differential DNA methylation is potentiated by SRC-1 in the endocrine resistant setting. Clin Cancer Res; 24(15); 3692–703. ©2018 AACR.
Too Much, Too Little, or the Wrong Kind of ‘Theory’ in the Study of Religions?
Authors: Kavanagh Christopher M. 
Published: March 2018

AbstractIn response to the recent publication ofTheory In a Time of Excessthis article offers an outsider perspective on the theoretical issues raised and why they are ultimately unlikely to be resolved. The article argues that there is a widespread problematic tendency to equatetheorywith a specific category ofcritical theorythat tautologically restricts the theoretical boundaries of the study of religion field and neglects the contributions of more empirically inclined theorists. In a similar manner, essentialising narratives about the Cognitive Science of Religion that portray the field as unified and monolithic are highlighted and the validity of such critiques is questioned.
Mechanisms of Meridional-Propagating High-Frequency Intraseasonal Oscillation Associated with a Persistent Rainfall over South China
Authors: Zheng Bin , Huang Yanyan 
Published: March 2018

Abstract
The present study divides the intraseasonal variations into high-frequency intraseasonal oscillation (HF-ISO) with a 5–20-day period and low-frequency ISO (LF-ISO) with a 30–60-day period. Here, defined HF-ISO is heavily different from some previous work, because, over south China, persistent rainfall (PR) is not only related to the quasi-biweekly oscillation (10–20-day period), but also connected with the quasi-weekly oscillation (5–10-day period). Associated with a PR over south China during the first half of June 2016 (PR1606), the propagating components of the convections are largely attributed to the HF-ISOs. Moreover, both southward- and northward-propagating HF-ISOs are found in this case. Over southern China, the moisture advection dominated by anomalous flow and mean water vapor plays an important role in the southward propagation of the HF-ISO, and the cloud–radiation effect may be also, at least partially, responsible for the southward shift of the associated convective zone. Nevertheless, two other possible mechanisms are introduced to explain the cause of the northward propagation of the HF-ISO over southern China during the PR1606 period. The first is the vorticity advection, which is a dominant factor. The second mechanism is the wind–evaporation effect that plays a minor role. Over the South China Sea, the northward propagation of the HF-ISO is mainly attributed to the vertical wind shear effect and the vorticity advection effect, and the latter is relatively more important than the former in this case. The moisture advection is a supplementary effect caused by inducing a weak positive moisture tendency north of the convection center.
In vivo MRI detection of atherosclerosis in ApoE-deficient mice by using tenascin-C-targeted USPIO
Authors: Li Yan , Liu Jun , Huang Jun-wen , Song Jia-cheng , Ma Zhan-long , Shi Hai-bin 
Published: March 2018

Background Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases. Non-invasive molecular imaging to detect and characterize the plaques is essential for reducing life-threatening cardiovascular events. Purpose To investigate the possibility of the anti-tenascin-C-USPIO specific probe as a molecular marker of atherosclerotic plaques detected by 7.0-T magnetic resonance imaging (MRI). Material and Methods Twenty ApoE-/- mice fed with a high fat diet were used for detecting the aorta arch atherosclerotic plaques by 7.0-T MRI at 16 and 24 weeks. Ten mice in the targeted group were injected with anti-tenascin-C-USPIO and another ten in the control group were injected with pure USPIO (n = 5 each time point in each group). Histopathologic examination was used to evaluate the plaques and immunohistochemistry analysis was used to compare tenascin-C expression. Results The relative signal intensity (rSI) changes of the targeted group decreased more than those of the control group (16 weeks: −15.65 ± 0.78% vs. −3.43 ± 2.57%; 24 weeks: −26.38 ± 1.54% vs. −11.12 ± 1.60%, respectively; P < 0.05). Histopathological analyses demonstrated visible atherosclerotic plaques formation and development over time from 16 weeks to 24 weeks. Tenascin-C expression of the plaques at 24 weeks was higher than that at 16 weeks (0.22 ± 0.04 vs. 0.13 ± 0.02, P < 0.05). The MR images correlated well with the progression of atherosclerotic plaques. Conclusion Tenascin-C expression increased with the progression of atherosclerosis. Anti-tenascin-C-USPIO could provide a useful molecular imaging tool for detecting and monitoring atherosclerotic plaques by MRI.
Predictive risk factors of failed laryngeal mask airway insertion at first attempt
Authors: Wang Jia , Shi Xiaoping , Xu Tao , Wang Geng 
Published: March 2018

Objectives A failed first attempt at laryngeal mask airway (LMA) insertion could increase the risk of laryngospasm, hypoxemia, and postoperative sore throat. This study was performed to investigate the risk factors for failed first-attempt LMA placement. Methods In total, 461 patients who underwent general anesthesia with a Supreme LMA (Teleflex Medical, Shanghai, China) and who had an American Society of Anesthesiologists (ASA) physical status of I to III were prospectively enrolled. The LMA was inserted after anesthetic induction. We recorded the insertion conditions and each patient’s age, ASA status, body weight, body mass index (BMI), duration of anesthesia, size of LMA, and cuff pressure; the years of work experience of the anesthesiologists; and the use or nonuse of lidocaine gel as a lubricant. Results Successful first-attempt placement of the Supreme LMA was achieved in 438 (95.10%) patients, while first-attempt placement failed in 23 (4.99%). Significant risk factors for failure of first-attempt LMA insertion included high age, high body weight, BMI of <20 kg/m2, and insertion without using lidocaine gel. Conclusions A patient age of >61 years, high body weight, BMI of <20 kg/m2, and insertion without lidocaine gel could significantly increase the risk of failed first-attempt Supreme LMA insertion.
Analysis of alterations in white matter integrity of adult patients with comitant exotropia
Authors: Li Dan , Li Shenghong , Zeng Xianjun 
Published: March 2018

Objective This study was performed to investigate structural abnormalities of the white matter in patients with comitant exotropia using the tract-based spatial statistics (TBSS) method. Methods Diffusion tensor imaging data from magnetic resonance images of the brain were collected from 20 patients with comitant exotropia and 20 age- and sex-matched healthy controls. The FMRIB Software Library was used to compute the diffusion measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). These measures were obtained using voxel-wise statistics with threshold-free cluster enhancement. Results The FA values in the right inferior fronto-occipital fasciculus (IFO) and right inferior longitudinal fasciculus were significantly higher and the RD values in the bilateral IFO, forceps minor, left anterior corona radiata, and left anterior thalamic radiation were significantly lower in the comitant exotropia group than in the healthy controls. No significant differences in the MD or AD values were found between the two groups. Conclusions Alterations in FA and RD values may indicate the underlying neuropathologic mechanism of comitant exotropia. The TBSS method can be a useful tool to investigate neuronal tract participation in patients with this disease.
Simulation of key interventions for seasonal influenza outbreak control at school in Changsha, China
Authors: Chen Tianmu , Zhao Bin , Liu Ruchun , Zhang Xixing , Xie Zhi , Chen Shuilian 
Published: March 2018

Objective To use a mathematical model to simulate an influenza outbreak in a school in order to assess the effectiveness of isolation (Iso), antiviral therapeutics, antiviral prophylactics (P), vaccination prior to the outbreak, and school closure (for 1 [S1w], 2 or 3 weeks). Methods This study developed a susceptible–exposed–infectious/asymptomatic–recovered model to estimate the effectiveness of commonly used interventions for seasonal influenza outbreaks in school. Results The most effective single-intervention strategy was isolation with a total attack rate of 1.99% and an outbreak duration of 30 days. The additional effectiveness of antiviral therapeutics and prophylactics and vaccination (prior to the outbreak) strategies were not obvious. Although Iso+P, P+Iso+S1w, four-, and five-combined intervention strategies had commendable effectiveness, total attack rate decreased only slightly, and outbreak duration was shortened by 9 days maximum, compared with the single-intervention isolation strategy. School closure for 1, 2 or 3 weeks was futile or even counterproductive. Conclusion Isolation, as a single intervention, was the most effective in terms of reducing the total attack rate and the duration of the outbreak.
Delivering cognitive behavioural interventions in an internet-based healthcare delivery environment
Authors: Nalder Emily , Marziali Elsa , Dawson Deirdre R. , Murphy Kelly 
Published: March 2018

Introduction This exploratory qualitative study assessed the feasibility of transitioning three face-to-face, cognitive behavioural interventions for adults with chronic health conditions to online delivery, by examining clinician and clients' satisfaction with intervention training and delivery. Method The interventions adapted for online delivery were: ‘Managing Chronic Disease’, a programme for individuals who were nonadherent to prescribed rehabilitation regimens; ‘Real-World Strategy Training’, an occupation-based intervention for individuals with subjective cognitive decline; and ‘Learning the Ropes’, a memory programme for persons with mild cognitive impairment. Two occupational therapists and one nurse received training in, and then delivered one of the three interventions. Qualitative feedback interviews with participants, and archived video recordings of intervention sessions were analysed thematically. Results Key features of each manualised intervention were evident in the online sessions and perceived by clients as enhancing engagement (for example, peer support and strategy training). Clinicians felt that meeting individually with intervention experts was helpful to problem-solve technical issues and ensure adherence to protocols. Conclusion Three cognitive behavioural interventions transitioned to online delivery were acceptable to older adults and clinicians. A next step would be to complete randomised controlled trials investigating whether the interventions yield equivalent health benefits, using online and face-to-face delivery.
Neonatal Macroglossia
Authors: Simmonds Jonathan C. , Patel Anju K. , Mildenhall Nicholas R. , Mader Nicholas S. , Scott Andrew R. 
Published: March 2018

Objectives: To examine the birth prevalence of congenital macroglossia and identify demographic variables and comorbidities that may influence length of stay and cost of care. Study Design: Retrospective cross-sectional study using the Kids’ Inpatient Database 2003, 2006, 2009, and 2012. Methods: Demographics were analyzed. Linear regression modeling and multivariate analyses were performed. Results: The birth prevalence of congenital macroglossia was 4.63/100 000 births. Patients were classified as isolated (n = 349, 48.1%) or syndromic (n = 377, 51.9%). A higher incidence of isolated macroglossia was seen in females (odds ratio, OR [95% confidence interval, 95% CI]: 1.93 [1.45-2.56] and African Americans (2.02 [1.41-2.88]). Length of stay was higher for syndromic patients than for nonsyndromic patients (22.6 days [18.6-26.6] vs 7.93 days [5.95-9.90], as were inpatient costs ($3619USD [$27 628-$44 754] vs $10 168USD [$6272-$14 064]. After accounting for gender, race, location, and socioeconomic status, the presence of macroglossia alone increased length of stay by 4.07 days (0.42-7.72 days) in nonsyndromic patients and 12.02 days (3.63-20.4 days) in syndromic patients. The cost of care increased by $6207USD ($576-$11 838) among nonsyndromic newborns and $17 205USD ($374-34 035) among syndromic patients. Conclusion: The birth prevalence of congenital isolated macroglossia appears to vary by sex and race. Prolonged length of stay and increased costs are associated with both isolated macroglossia and syndromic macroglossia, even after controlling for other syndromic comorbidities.
Sociodemographic Predictors of Missed Appointments Among Patients With Cleft Lip and Palate
Authors: Lynn Jeremy V. , Ranganathan Kavitha , Bageris Matthew H. , Hart-Johnson Tami , Buchman Steven R. , Blackwood R. Alexander 
Published: March 2018

Objective: To identify disparities in compliance of and care for patients with cleft lip and/or palate (CL/P) by determining the impact of sociodemographic variables on the rate of missed appointments and Child Protective Services (CPS) involvement. Design: A retrospective, noninterventional quality assessment and quality improvement study were designed. Setting: This institutional study was performed at the University of Michigan in Ann Arbor, Michigan. Patients: All patients born between January 1, 2011, and December 31, 2014, who underwent surgical CL/P repair, excluding those with fewer than 5 appointments (n = 178). Main Outcome Measure: The rate of missed appointments, calculated as the total number of no-show appointments divided by the total number of scheduled appointments. All appointments from CL/P diagnosis to data collection were considered, including those outside of plastic surgery. Results: The average patient was 4.5 years of age and had 49 total scheduled appointments. The overall rate of missed appointments was 9.6%, with 66.8% of patients missing at least 1 scheduled visit. Patients who were black ( P = .04), not affiliated with a religion ( P = .01), Medicaid users ( P = .01), from an unstable social background ( P = .01), or received need-based financial assistance ( P = .00) were significantly more likely to miss appointments. Child Protective Services was involved with 3.9% of patients. Conclusions: Disparities exist in attendance rates among patients with CL/P, and at-risk patient populations have been identified. The allocation of cleft care resources must be efficiently planned in order to enhance the quality of care for at-risk individuals.
Treatment with platelet-rich plasma of surgically related dormant corneal ulcers
Authors: Alio Jorge L , Rodriguez Alejandra E , De Arriba Pablo , Gisbert Sandra , Abdelghany Ahmed A 
Published: March 2018

Purpose: To assess the effectiveness of autologous platelet-rich plasma for the treatment of dormant corneal ulcers secondary to corneal surgery and unresponsive to conventional treatment. Setting: VISSUM, Ophthalmology Institute of Alicante, Alicante, Spain. Design: Prospective nonrandomized, observational consecutive study. Methods: A total of 44 eyes of 28 patients with dormant corneal ulcers secondary to corneal surgery were included in a prospective study and treated with autologous platelet-rich plasma during 6 weeks. Wilcoxon signed-rank test was used to compare the effect of the treatment. Results: In all, 28 patients (65.1%) improved their visual acuity at least one line in Snellen chart, 26 (59.09%) had a decrease in the size of the ulcer or even a total closure, and 40 (90.9%) experienced an improvement in their symptoms. The results are also provided for the four groups of patients (keratoplasty, refractive surgery, cross-linking, and chronic postsurgical corneal edema). Conclusion: Platelet-rich plasma eye drops shows to be a good option for the treatment of dormant corneal ulcers secondary to corneal surgery.
Comparing capsular bag performance of a hydrophilic and a hydrophobic intraocular lens: A randomised two-centre study
Authors: Koshy John , Hirnschall Nino , Vyas Ashok Kumar V , Narendran R , Crnej Alja , Gangwani Vinod , Nishi Yutaro , Maurino Vincenzo , Findl Oliver 
Published: March 2018

Purpose: To evaluate the capsular bag performance and posterior capsule opacification development of two intraocular lenses differing in material and design. Methods: This study included patients who were scheduled for cataract surgery and compared a hydrophilic intraocular lens (Super flex® intraocular lens; Rayner Surgical, Worthing, UK) with a hydrophobic intraocular lens (AcrySof® SA60AT; Alcon, Fort Worth, TX, USA). Follow-ups were performed 1 month and 2 years after cataract surgery, including a slit lamp examination and retroillumination images. Results: In total, 80 eyes of 80 patients were recruited. At the 1-month follow-up, 6 of 39 cases had a gap between the posterior lens capsule and intraocular lens (1 case in the hydrophilic intraocular lens group and 5 cases in the hydrophobic intraocular lens group; p = 0.348). Objective and subjective posterior capsule opacification scoring showed no statistically significant difference between both groups (p = 0.123). Conclusion: Both intraocular lens showed a good capsular bag performance and a relatively low posterior capsule opacification development within the first 2 years after surgery.
Comparative evaluation of Scheimpflug tomography parameters between thin non-keratoconic, subclinical keratoconic, and mild keratoconic corneas
Authors: Huseynli Samira , Salgado-Borges José , Alio Jorge L 
Published: March 2018

Purpose: To evaluate and compare the topographic and topometric parameters, thickness profile data, and data from enhanced elevation maps of thin non-keratoconic, subclinical keratoconic, and mild keratoconic corneas with the Pentacam Scheimpflug corneal tomography and to study the usefulness of different parameters to differentiate keratoconus from topographically normal thin corneas. Methods: The study included 30 eyes with subclinical keratoconus, 30 eyes with mild-stage keratoconus, and 54 healthy eyes with minimal pachymetry ≤500 µm, with a mean age of 21.19 ± 2.97, 21.75 ± 1.93, and 21.5 ± 2.95 years, respectively. The area under the receiver operating characteristic curves was used to analyze the diagnostic significance of the Pentacam parameters. Results: The anterior and posterior corneal elevations, pachymetric progression, the percentage of thickness increase measurements, overall D value, and topometric indices were statistically significantly higher in subclinical and mild keratoconic corneas than in normal eyes with thin cornea (p < 0.05). All these parameters had sufficient strength (area under the receiver operating characteristic curves >0.90) to differentiate clinical keratoconus. Posterior elevation showed the excellent area under the receiver operating characteristic curves with 100% sensitivity and 100% specificity for this purpose. However, among all parameters studied, the anterior elevation (0.935) showed the excellent area under the receiver operating characteristic curves to differentiate subclinical keratoconus, followed by posterior elevation (0.897), index of height decentration (0.887), and D value (0.882). Conclusion: The parameters derived from the Scheimpflug device, such as corneal elevations and overall D value, can effectively differentiate subclinical and clinical keratoconus from non-keratoconic thin cornea eyes. However, the specificity levels of these parameters were relatively limited in the diagnosis of subclinical keratoconus.