bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid label-free identification of pathogenic bacteria species from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network
Authors: Kim Geon , Ahn Daewoong , Kang Minhee , Park Jinho , Ryu DongHun , Jo YoungJu , Song Jinyeop , Ryu Jea Sung , Choi Gunho , Chung Hyun Jung , Kim Kyuseok , Chung Doo Ryeon , Yoo In Young , Huh Hee Jae , Min Hyun-seok , Lee Nam Yong , Park YongKeun 
Published: April 2019

AbstractThe healthcare industry is in dire need for rapid microbial identification techniques. Microbial infection is a major healthcare issue with significant prevalence and mortality, which can be treated effectively during the early stages using appropriate antibiotics. However, determining the appropriate antibiotics for the treatment of the early stages of infection remains a challenge, mainly due to the lack of rapid microbial identification techniques. Conventional culture-based identification and matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy are the gold standard methods, but the sample amplification process is extremely time-consuming. Here, we propose an identification framework that can be used to measure minute quantities of microbes by incorporating artificial neural networks with three-dimensional quantitative phase imaging. We aimed to accurately identify the species of bacterial bloodstream infection pathogens based on a single colony-forming unit of the bacteria. The successful distinction between a total of 19 species, with the accuracy of 99.9% when ten bacteria were measured, suggests that our framework can serve as an effective advisory tool for clinicians during the initial antibiotic prescription.Abstract Figure
Translational control of breast cancer plasticity
Authors: Jewer Michael , Lee Laura , Zhang Guihua , Liu Jiahui , Findlay Scott D. , Vincent Krista M. , Tandoc Kristofferson , Dieters-Castator Dylan , Quail Daniela F. , Dutta Indrani , Coatham Mackenzie , Xu Zhihua , Guan Bo-Jhih , Hatzoglou Maria , Brumwell Andrea , Uniacke James , Patsis Christos , Koromilas Antonis , Schueler Julia , Siegers Gabrielle M. , Topisirovic Ivan , Postovit Lynne-Marie 
Published: April 2019

AbstractPlasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast cancer cells NANOG, SNAIL and NODAL transcripts manifest multiple isoforms characterized by different 5’ Untranslated Regions (5’UTRs), whereby translation of a subset of these isoforms is stimulated under hypoxia. This leads to accumulation of corresponding proteins which induce plasticity and “fate-switching” toward stem-cell like phenotypes. Surprisingly, we observed that mTOR inhibitors and chemotherapeutics induce translational activation of a subset of NANOG, SNAIL and NODAL mRNA isoforms akin to hypoxia, engendering stem cell-like phenotypes. Strikingly, these effects can be overcome with drugs that antagonize translational reprogramming caused by eIF2α phosphorylation (e.g. ISRIB). Collectively, our findings unravel a hitherto unappreciated mechanism of induction of plasticity of breast cancer cells, and provide a molecular basis for therapeutic strategies aimed at overcoming drug resistance and abrogating metastasis.
Synthetic hybrids of six yeast species
Authors: Peris David , Alexander William G. , Fisher Kaitlin J. , Moriarty Ryan V. , Basuino Mira G. , Ubbelohde Emily J. , Wrobel Russell L. , Hittinger Chris Todd 
Published: April 2019

AbstractAllopolyploidy generates diversity by increasing the number of copies and sources of chromosomes. Many of the best-known evolutionary radiations, crops, and industrial organisms are ancient or recent allopolyploids. Allopolyploidy promotes differentiation and facilitates adaptation to new environments, but the tools to test its limits are lacking. Here we develop an iterative method to combine the genomes of multiple budding yeast species, generatingSaccharomycesallopolyploids of an unprecedented scale. Chromosomal instability and cell size increased dramatically as additional copies of the genome were added, but we were able to construct synthetic hybrids of up to six species. The six-species hybrids initially grew slowly, but they rapidly adapted when selection to a novel environment was applied, even as they retained traits from multiple species. These new synthetic yeast hybrids have potential applications for the study of polyploidy, genome stability, chromosome segregation, cancer, and bioenergy.One sentence summaryWe constructed six-species synthetic hybrids and showed that they were chromosomally unstable but able to adapt rapidly.
Improvement in auditory spatial discrimination from ambiguous visual stimuli is not explained by ideal observer causal inference
Authors: Cappelloni Madeline S. , Shivkumar Sabyasachi , Haefner Ralf M. , Maddox Ross K. 
Published: April 2019

AbstractIn order to survive and function in the world, we must understand the content of our environment. This requires us to gather and parse complex, sometimes conflicting, information. Yet, the brain is capable of translating sensory stimuli from disparate modalities into a cohesive and accurate percept with little conscious effort. Previous studies of multisensory integration have suggested that the brain’s integration of cues is well-approximated by an ideal observer implementing Bayesian causal inference. However, behavioral data from tasks that include only one stimulus in each modality fail to capture what is in nature a complex process. Here we employed an auditory spatial discrimination task in which listeners were asked to determine on which side they heard one of two concurrently presented sounds. We compared two visual conditions in which task-uninformative shapes were presented in the center of the screen, or spatially aligned with the auditory stimuli. We found that performance on the auditory task improved when the visual stimuli were spatially aligned with the auditory stimuli—even though the shapes provided no information about which side the auditory target was on. We also demonstrate that a model of a Bayesian ideal observer performing causal inference cannot explain this improvement, demonstrating that humans deviate systematically from the ideal observer model.
Impact investing in South Africa: managing tensions between financial returns and social impact
Authors: Mogapi Eunivicia Matlhogonolo , Sutherland Margaret Mary , Wilson-Prangley Anthony 
Published: April 2019

Purpose
Impact investment is an emergent field worldwide and it can play an especially important role in Africa. The aim of this study was to examine how impact investors in South Africa manage the tensions between financial returns and social impact.

Design/methodology/approach
The research was based on 15 semi-structured interviews with key stakeholders in the impact investment community in South Africa to understand the related challenges, trade-offs and tensions.

Findings
There are two opposing views expressed as to whether the tensions between financial return and social impact result in trade-offs. It is proposed that impact investors embrace this duality and seek to approach it through a contingency and a paradox view. The tensions can be approached by focussing on values alignment, contracting processes, engaged leadership and sector identification. The authors integrate the findings into a proposed framework for effective tension management in an impact investment portfolio.

Research limitations/implications
This study was limited to selected South African interviewees. It would be valuable to extend the study to other African countries.

Practical implications
The issue of values alignment between investors, fund managers and investee firms is an important finding for practice. As is the four-part iterative framework for sensing the operating environment, defining impact, organising internally and defining the investment approach.

Originality/value
This study contributes empirical evidence to scholarship around organisational tensions, especially work in hybrid organisations. It affirms the value of a nuanced application of paradox theory. It examines these tensions through the lived experience of impact investing professionals in an emerging market context.
Early decision-making for school building renovation
Authors: Farsäter Karin , Olander Stefan 
Published: April 2019

Purpose
The purpose of this study was to evaluate how decisions are taken in the early stages of a renovation project, up to the design brief, leading up to the decisions on how to proceed with the renovation in the design phase. Although many technical solutions are visualised in the design phase, it is in the early evaluations of needs and demands, leading up to the design brief, that set the requirements for viable solutions in the design and production phases.

Design/methodology/approach
The study was carried out as a longitudinal case study of the planning phases of a school renovation. The studied buildings were researched by document analysis and by attending meetings over a four-year period between the building owners and the municipality.

Findings
Aspects such as technical status, energy use and indoor environment in the buildings were not discussed to any great extent. A few inventories were carried out in the buildings to establish their technical and accessibility status. The aspects mainly discussed in the studied renovation project have been: accessibility, functionality with respect to teaching and learning requirements in addition to architectural and cultural values.

Originality/value
This study illustrates the comprehensive analysis needed when renovating a building and on difficulties of addressing and evaluating all the viable aspects of concern. It also shows that this planning for a renovation is not a straight line but rather a process where conditions are continuously changing.
Intelligent transaction: definition, modes, and research directions
Authors: Qiu Leiju , Zhao Yang , Liu Qian , Sun Baowen , Wu Xiaolin 
Published: April 2019

Purpose
In the crowd intelligence networking era, the smart connections of human, machines and things enable point-to-point trustable transactions and distributed efficient collaboration; the smart connections among government, enterprises, organizations and the public would enable active participation of the public in society management and decision-making and improve the efficiency of government management and services. All interactions among various agents can be viewed as the transaction activity. The social division of labor system drives the evolution of transaction. The transaction mode also differentiated into different patterns with the development of human society. What will be the intelligent transaction in the crowd intelligence networking era? What will be the transactions modes and rules in the crowd intelligence networking era? The answers to these questions are of great importance to the future development of transactions.

Design/methodology/approach
The authors review the evolution of traditional transaction and transaction modes and analyze the driving forces of it. They attempt to give the definitions of intelligent transaction and intelligent transaction mode. They also review the traditional transaction modes and rules, analyze the characteristics of the intelligent transaction and classify the intelligent transaction modes.

Findings
The authors find the intelligent transaction is mainly reflected in the intellectualization of transaction subject, transaction object and transaction process. They summarize the characteristics of intelligent transaction and develop four modes for the intelligent transactions based on the modularization level of the transaction objects and the quantity of transaction subjects, including the demand side and the supply side. The authors also show representative examples to further illustrate rules and features of these transaction modes and point out the potential research directions.

Originality/value
This study is among the first to analyze the characteristics of the intelligent transaction, and the proposed division framework of the intelligent transaction modes could not only add value to the future research of intelligent transaction modes and rules but also help to guide the transactions in the crowd intelligence network.
Manifestations of social class and agency in cultural capital development processes
Authors: Yeröz Huriye 
Published: April 2019

Purpose
While migrant women entrepreneurs (MWE) have been studied extensively through the lenses of gender and ethnicity, social class, as an axis of difference, received scant attention in entrepreneurship and migrant enterprise literature. The purpose of this paper is to make an intersectional analysis on migrant women’s cultural capital development processes on the basis of not only gender and ethnicity, but also class relations.

Design/methodology/approach
The study draws on empirical insights generated through listening to the life story narratives of 17 women entrepreneurs from Turkey. This is a small, yet diverse group consisting of women who followed their male kin who have migrated to Sweden in the late 1960s as a labour force, and of highly educated political refugee women who have migrated to Sweden following the military coup in Turkey in the 1980s.

Findings
By linking pre-migration and post-migration lives through Bourdieusian class analysis, the analysis yielded three distinct types of habitus of the women-intersectional identity constructed through interweaving of certain historical and cultural practices and conditions, labelled as women (immigrant) entrepreneurs, migrant (women) entrepreneurs and hybrid entrepreneurs. Life stories demonstrated the ways the MWE relationally defined, and in turn, contested being the right kind of entrepreneur drawing on their type of habitus and forms of cultural capital within the rules of the game in the specific context of entrepreneurship.

Originality/value
This study shows how MWE generate diverse, yet at times similar, but historically and culturally conditioned responses in actively shaping the relationship between entrepreneurial resources and context-specific structural powers and aspects. This way, the study calls for enriching the extant debate on migrant women entrepreneurship in two ways. First, it suggests that the strategic fit between resources and opportunities does not entail an automatic and arbitrary process. Rather, it takes an effort and contestation carried out by the entrepreneurial actors, among whom the individual entrepreneur is the primary actor. In particular, it draws attention to the conditions of possibilities for agency as a result of struggle and intersectional power relations: social class, ethnicity and gender, which provide a differential degree of powers to the individual entrepreneur.
Integrating stated preference methods for property valuations in housing markets
Authors: Miccoli Saverio , Finucci Fabrizio , Murro Rocco 
Published: April 2019

Purpose
The study aims to propose an appraisal procedure based on the preferences stated by a sample of potential consumers and producers which makes it possible to obtain the hypothetical demand and supply curves and to estimate the most likely market value and transaction quantities for housing markets with unrevealed prices.

Design/methodology/approach
The procedure is divided into two steps: the first is aimed at selecting the alternatives that are most likely to meet the market’s preference by applying discrete choice (DC) analysis; the second makes it possible to estimate the potential demand and supply curves for the preferable alternatives singled out through DC analysis by using contingent valuation methods.

Findings
The results obtained considering only the hypothetical demand or the hypothetical supply differ by an average of 10 per cent from the actual sale price. Conversely, the values detected as the intersection of the hypothetical demand curve and the hypothetical supply curve, fall into variation margins that can be considered fully acceptable in real estate appraisal

Originality/value
As opposed to the applications performed in international real estate operations where reference is made solely to the potential demand estimate, the described procedure estimates the transaction value as the intersection between the hypothetical demand and supply curves, for the purposes of keeping account of the conditions that generally occur in the real market. Furthermore, it is possible to detect the incidence of the characteristics in market price formation, and to identify the market share of possible alternative assets and estimate the optimal quantity to be produced.
A proposed human resource management model for zakat institutions in Malaysia
Authors: Hasan Aznan , Hassan Rusni , Engku Ali Engku Rabiah Adawiah , Engku Ali Engku Muhammad Tajuddin , Abduh Muhamad , Noordin Nazrul Hazizi 
Published: April 2019

Purpose
The purpose of this study is to propose a contemporary human resource management (HRM) framework by zakat institutions, which collect and manage religious alms, both obligatory (zakat) and voluntary (ṣadaqah), in Malaysia.

Design/methodology/approach
In doing so, discussions pertaining to the key elements of zakat institutions’ HRM including recruitment, selection, performance appraisal, training and development and compensation are gathered from the existing literature and other sources of information such as zakat institutions’ websites and publications. In addition, zakat officers’ insight on how HRM is practiced at their institutions is gathered through a series of semi-structured interviews and incorporated in the findings of this study.

Findings
The paper finds that the state government, by virtue of the State Islamic Religious Council (SIRC), which is the sole trustee of all waqf properties in Malaysia, may have significant influence in formulating the human resource strategies and policies in zakat institutions.

Research limitations/implications
The proposed HRM model can be a useful reference for SIRC in enhancing the current human resource practice in its respective zakat institutions.

Originality/value
The novelty of this study lies in the proposed HRM model applicable to zakat institutions. The model emphasizes the alignment between the zakat institutions’ HRM practice and their zakat collection and distribution goals, as well as zakat management objectives in general.
Impact of genomics on biopharmaceutical industry: rare diseases as disruptive innovation
Authors: Ahn Mark J. , Shaygan Amir , Weber Charles 
Published: April 2019

PurposeUsing a dynamic capabilities lens, this paper aims to study the impact of genomics generally and gene therapy specifically on the rare disease sector of the biopharmaceutical industry.Design/methodology/approachIn this study, 24 genomics-based, rare disease-focused biopharma companies were studied and several variables were tested with respect to enterprise value growth. The companies were analyzed as a group of rare disease firms, as well as by size.FindingsThe authors found that number of employees, revenues, number of pipeline and marketed products and retained earnings are strongly correlated (in that order) with enterprise value in rare disease focused biopharma companies. These correlations seem to be weaker as a company’s market capitalization size decreases, indicating that there tends to be increasing returns to scale.Research limitations/implicationsThis study found that increasing rates of cumulative returns to enterprise value growth depends on accumulating knowledge-based employees and expanding product portfolios of disruptive genomics-based technologies for treating rare diseases. Aggregating skilled and innovative employees (especially in bigger companies) can be seen as a cumulative bolstering factor in leveraging dynamic capabilities which can be recognized, understood and transformed into commercial success (i.e. increasing returns in enterprise value). In other words, technology managers’ job is to manage not only the financial aspects of the technology but also human resources, asset configuration and strategic alliances efficiently toward faster and better innovation. Strong dynamic capabilities can be formed with the accumulation of experience, articulation and codification of knowledge and an adaptive ability to change the way they solve problems as their environment transforms.Originality/valueThis is the first study to demonstrate and measure a relationship between dynamic capabilities and enterprise value in genomics-based rare disease firms. Further, this study highlights the importance of building the capability and capacity to absorb expertise and accumulate knowledge for new product innovations and sustainable competitive advantage in industries characterized by disruptive innovation.
New evidence on fund performance in extreme events
Authors: Mansor Fadillah , Al Rahahleh Naseem , Bhatti M. Ishaq 
Published: April 2019

PurposeThe purpose of this paper is to compare the return performance and persistence of ethical and conventional mutual funds during two extreme events, the Asian and the global financial crises under Shariah constraints.Design/methodology/approachThe overall sample comprises of 129 Islamic mutual funds (IMFs) and 350 conventional mutual funds (CMFs) in Malaysia, and the average monthly data cover two periods of market cycles, before and during a financial crisis. The net of all expenses data is obtained from the Morningstar Database. This study employs various market risk-adjusted performance measures (ratios) to estimate the funds’ overall performance during the crises, and then it uses CAPM model to estimate the parameters via panel data approach. Moreover, paper employs the two persistence performance measures on IMFs and CMFs through contingency tables. It tests for the performance persistence effects for IMFs, CMFs using repeat winner and the cross-product ratio (CPR) tests proposed by Malkiel (1995) and Brown and Goetzmann (1995), respectively.FindingsThe main findings of the paper are: on average, both funds IMF and the CMF outperform the market return during the entire sample period; none of the funds is better than the “others” during the financial crises and the pre-crisis periods; the ethical fund – IMF outperforms the CMF over the study period. This outcome also indicates that ethical funds are more persistent especially during and the pre-crisis AFC and the GFC periods.Research limitations/implicationsThe finding of this study is limited to only Malaysian data because the objective was to guideline investors and market players in Malaysia to prefer investing in Islamic ethical funds to diversify their investment portfolio.Practical implicationsCautions to use existing ratio measures and CAPM model rather persistence measures may be used with existing methodologies in light of extreme events which influenced investor decision making for better returns at lower risks.Social implicationsA class of ethical funds consists of religious sustainable, socially responsible and impact-investing (SRI) funds but Shariah implications of halal investment must be observed to avoid prohibited practices within the class of SRI funds.Originality/valueThe work done in this paper are original in the sense that the authors employed various ratios to measure fund performance in conjunction with CAPM model and then tested for two persistence performance measures; the repeat winner and CPR tests.