bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐Scale Transparent Molybdenum Disulfide Plasmonic Photodetector Using Split Bull Eye Structure
Authors: Sourav Adhikary , Li Zhiwen , Huang Zhonghui , Botcha Venkata Divakar , Hu Cong , Ao Jin‐Ping , Peng Yangfan , Kuo Hao‐Chung , Wu Jing , Liu Xinke , Ang Kah‐Wee 
Published: July 2018

AbstractA high performance photodetector array on transparent substrate is highly sought after for enabling next‐generation imaging technology at the visible wavelengths. 2D materials such as molybdenum disulfide (MoS2) are attractive for such application owing to its superior optoelectronic properties and transparency when scaled to atomic thinness. Here, direct growth of MoS2 on centimeter‐scale transparent Al2O3 substrate is reported using a high yield and scalable chemical vapor deposition approach. This enables a large area photodetector array to be demonstrated, wherein aluminum split bull eye (SBE) plasmonic structure is integrated to achieve further performance boost due to surface plasmon resonance (SPR) effect. For a wavelength of 405 nm, the plasmonic MoS2 detector achieves an ultralow noise equivalent power of ≈6.2 × 10–14 W Hz−1/2 and a high responsivity of 7.26 A W−1 at a small bias of 1.0 V, which is more than 6× larger than the reference detector due to SPR effect. Finite‐difference time‐domain simulation confirms a higher concentration of optical field distribution at the center of the SBE structure, which is responsible for the enhancement of photocurrent and sensitivity even at low‐light condition.
Reaction of β‐(2‐aminophenyl)‐α,β‐Ynones with Tosyl Isocyanate: Experimental and Computational Investigations
Authors: Rode Navnath D. , Aschi Massimiliano , Chiarini Marco , Del Vecchio Luana , Marinelli Fabio , Arcadi Antonio 
Published: July 2018

AbstractA practical metal‐free approach to the synthesis of 2‐aroyl‐N‐tosyl‐1H‐indole‐3 carboxamides through an unprecedented sequential 5‐endo‐dig cycloamination /carboxamidation reaction of β‐(2‐aminophenyl)‐α,β‐ynones with the tosyl isocyanate is described. A computational model gives a plausible rationale for the unexpected results.magnified image
Primary myelofibrosis: 2019 update on diagnosis, risk‐stratification and management
Authors: Tefferi Ayalew 
Published: July 2018

AbstractDisease overviewPrimary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell‐derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional disease features include bone marrow stromal reaction including reticulin fibrosis, abnormal cytokine expression, anemia, hepatosplenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival.DiagnosisDiagnosis of PMF is based on bone marrow morphology. Presence of JAK2, CALR, or MPL mutation, expected in ∼ 90% of the patients, is supportive but not essential for diagnosis. The revised 2016 World Health Organization (WHO) classification system distinguishes “prefibrotic” from “overtly fibrotic” PMF; the former might mimic ET in its presentation and it is prognostically relevant to distinguish the two.Risk stratificationTwo new prognostic systems for PMF have recently been introduced: GIPSS (genetically inspired prognostic scoring system) and MIPSS70+ version 2.0 (mutation‐ and karyotype‐enhanced international prognostic scoring system). GIPSS is based exclusively on mutations and karyotype. MIPSS70+ version 2.0 utilizes both genetic and clinical risk factors. GIPSS features four and MIPSS70+ version 2.0 five risk categories. MIPSS70+ version 2.0 requires an online score calculator (http://www.mipss70score.it) while GIPPS offers a lower complexity prognostic tool.Risk‐adapted therapyObservation alone is advised for MIPSS70+ version 2.0 “low” and “very low” risk disease (estimated 10‐year survival 56%‐92%); allogeneic stem cell transplant is the preferred treatment of choice for “very high” and “high” risk disease (estimated 10‐year survival 0‐13%); treatment‐requiring patients with intermediate‐risk disease (estimated 10‐year survival 30%) are best served by participating in clinical trials. All other treatment approaches, including the use of JAK2 inhibitors, are mostly palliative and should not be used in the absence of clear treatment indications. Conventional treatment for anemia includes androgens, prednisone, thalidomide and danazol, for symptomatic splenomegaly hydroxyurea and ruxolitinib and for constitutional symptoms ruxolitinib. Splenectomy is considered for drug‐refractory splenomegaly and involved field radiotherapy for nonhepatosplenic EMH and extremity bone pain.
Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines
Authors: Gopalaiah Kovuru , Rao Devarapalli Chenna , Mahiya Kuldeep , Tiwari Ankit 
Published: July 2018

AbstractAbundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed.
Reliability and validity of the Korean version of the Questionnaire of Olfactory Disorders
Authors: Choi Woo Ri , Jeong Hyeon‐Yeong , Kim Ji Heui 
Published: July 2018

BackgroundThe Questionnaire of Olfactory Disorders (QOD) is a self‐report questionnaire that provides subjective information about olfactory dysfunction. The QOD is widely used in clinical practice because of its high level of reliability and efficacy in Western countries. In this study we evaluated the reliability and validity of the Korean version of the QOD.MethodsA total of 213 patients with subjective olfactory dysfunction completed 2 different surveys (the QOD and the 36‐item Short‐Form Health Survey [SF‐36]). Patients’ olfactory function was evaluated by a screening cross‐cultural smell identification test or the Korean version of the Sniffin' Sticks (KVSS) II Test. The Korean version of the QOD was evaluated for split‐half reliability and internal consistency. Criterion validity of QOD was determined by comparing with the SF‐36.ResultsThe split‐half reliability was 0.967. Cronbach α coefficients for internal consistency of the QOD parosmia statements (QOD‐P), QOD life quality statements (QOD‐LQ), QOD sincerity statements (QOD‐S), and QOD visual analog scale statements (QOD‐VAS) were 0.705, 0.909, 0.243, and 0.953, respectively. There were statistically significant correlations between the SF‐36 and the QOD‐P, QOD‐LQ, QOD‐S, and QOD‐VAS scores. There were no significant differences in QOD scores among patients with anosmia, hyposmia, and normosmia on the olfactory function test. Mean scores on the QOD‐P, QOD‐LQ, and QOD‐VAS were significantly higher in 15 patients with normosmia on the olfactory function test when compared with 13 healthy controls.ConclusionThe Korean version of the QOD has proven to be a generally reliable and valid questionnaire to assess the degree of subjective olfactory dysfunction in the evaluation of Korean patients suspected of having olfactory dysfunction.
A Hierarchical Coding Strategy for Live Cell Imaging of Protein‐Specific Glycoform
Authors: Li Siqiao , Liu Yiran , Liu Lu , Feng Yimei , Ding Lin , Ju Huangxian 
Published: July 2018

AbstractLive cell imaging of protein‐specific glycoforms holds great promise for revolutionizing the study of glycochemistry. The imaging protocols developed thus far build upon the paired interplay of probe units, thus limiting the number of monosaccharide identification channels. A hierarchical coding (HieCo) imaging strategy, with DNA coding and decoding of protein and monosaccharides executed in fidelity to the hierarchical order of target glycoprotein, is reported herein and features expandable monosaccharide identification channels. A proof‐of‐concept protocol has been developed for MUC1‐specific imaging of terminal sialic acid (Sia) and fucose (Fuc) on MCF‐7, T47D, MDA‐MB‐231, and PANC‐1 cells, revealing distinct monosaccharide patterns for four types of cells. The protocol also permits dynamic monitoring of changes in MUC1‐specific monosaccharide patterns associated with both the alteration of cellular physiological states and the occurrence of a biologically important process.
TBAI/TBHP‐Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ‐Keto Diesters
Authors: Chowdhury Soumyadeep Roy , Hoque Injamam Ul , Maity Soumitra 
Published: July 2018

AbstractA metal‐free protocol for oxidative coupling of malonic esters with styrenes to form γ‐keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo‐catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal‐free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ‐keto diesters.
Influence of Nitrogen‐Doping for Carbide‐Derived Carbons on the Supercapacitor Performance in an Organic Electrolyte and an Ionic Liquid
Authors: Krüner Benjamin , Odenwald Christina , Quade Antje , Kickelbick Guido , Presser Volker 
Published: July 2018

AbstractWe investigated the influence of nitrogen groups on the electrochemical performance of carbide‐derived carbons by comparing materials with a similar pore structure with and without nitrogen‐doping. These materials were tested in a half‐cell and full‐cell supercapacitor setup with a conventional organic electrolyte (1 M tetraethylammonium tetrafluoroborate in acetonitrile) and an ionic liquid (1‐ethyl‐3‐methylimidazolium tetrafluoroborate). Varying the nitrogen content in the range of 1–7 mass % had no systematic influence on the energy storage capacity but a stronger impact on the rate handling ability. The highest specific capacitance in a half‐cell supercapacitor at a negative potential was 215 F/g in EMIM‐BF4. Using the best‐performing carbide‐derived carbon with and without nitrogen‐doping (i. e., by applying a synthesis temperature of 800 °C), the full‐cell performance was 174 F/g, which results in a high specific energy of 61 Wh/kg in EMIM‐BF4. For the same materials, the corresponding specific energy was about 30 Wh/kg when using the organic electrolyte.
Development of a shake tube‐based scale‐down model for perfusion cultures
Authors: Wolf Moritz K.F. , Lorenz Veronika , Karst Daniel J. , Souquet Jonathan , Broly Hervé , Morbidelli Massimo 
Published: July 2018

AbstractThe use of benchtop bioreactors (BRs) for the development of mammalian cell perfusion cultures is expensive and time consuming, given its complexity in equipment and operation. Scale‐down models, going from liter to milliliter scale, are needed to support the rapid determination of suitable operating conditions in terms of viable cell density (VCD), perfusion rate, and medium composition. In this study, we compare the performance of steady‐state perfusion cultures in orbitally shaken tube and BR systems for a given Chinese hamster ovary cell line. The developed scale‐down model relied on a daily workflow designed to keep the VCD constant at specific target values. This includes: cell count, removal of excessive cells (bleeding), spin down of remaining cells, harvest of cell‐free supernatant, and resuspension in fresh medium. Steady‐state cultures at different VCD values, medium exchange rates and working volumes were evaluated. Shake‐tube perfusion cultures allowed the prediction of cell‐specific growth, glucose consumption, ammonia, and monoclonal antibody production rates for much larger BRs, but not lactate (LAC) production rates. Although charge variant profiles remained comparable, different glycosylation patterns were obtained. The differences in LAC production and glycosylation probably resulted from the discontinuous medium exchange, the poor carbon dioxide removal, and the deficient pH control. Therefore, if requested by the specific process to be developed, product quality has to be fine‐tuned directly in the BR system. Altogether, the developed strategy provides a useful scale‐down model for the design and optimization of perfusion cultures with strong savings in time and media consumption.
Interferon gamma in cancer immunotherapy
Authors: Ni Ling , Lu Jian 
Published: July 2018

AbstractImmune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5‐year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well‐known functions, IFNγ signaling also induces tumor ischemia and homeostasis program, resulting in tumor clearance and tumor escape, respectively. The yin and the yang of IFNγ signaling are summarized. Thus, this review helps us to comprehensively understand the roles of IFNγ in tumor immunity, which contributes to better design and management of clinical immunotherapy approaches.
Implicit communication of food product healthfulness through package design: A content analysis
Authors: Festila Alexandra , Chrysochou Polymeros 
Published: July 2018

AbstractHow do food companies use package design to communicate healthfulness? The present study addresses this question by investigating the most typical implicit package design elements used by food companies for their health‐positioned food products. Using a content analysis on the packaging design of 12 food product categories across two countries (Denmark and the United States), our findings indicate that (a) implicit package design elements (colors, imagery, material, and shape) differ between health‐positioned and regular products, and (b) these differences are product category specific rather than universal. Our results contribute to knowledge on how package design is used as a health communication tool.
The mRNA‐binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes
Authors: Muto Akiko , Sugihara Yoshihiko , Shibakawa Minami , Oshima Kenzi , Matsuda Tsukasa , Nadano Daita 
Published: July 2018

While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of cytoplasmic ribosomes including differences in protein composition and chemical modifications. However, the current knowledge on the heterogeneity of mammalian ribosomes is limited. Here, we report mammalian Serbp1 as a ribosome‐associated protein. The translated products of Serbp1 gene, including the longest isoform, were found to be localized in the nucleolus as well as in the cytoplasm. Subcellular fractionation indicated that most of cytoplasmic Serbp1 molecules were precipitated by ultracentrifugation. Proteomic analysis identified Serbp1 in the cytoplasmic ribosomes of the rodent testis. Polysome profiling suggested that Serbp1, as a component of the small 40S subunit, was included in translating ribosomes (polysomes). Cosedimentation of Serbp1 with the 40S subunit was observed after dissociation of the ribosomal subunits. Serbp1 was also included in the ribosomes of human cancer cells, which may lead to a mechanistic understanding of an emerging link between Serbp1 and tumour progression.Significance of the studyIn mammalian cells, the final protein output of their genetic program is determined not only by controlling transcription but also by regulating the posttranscriptional events. Although mRNA‐binding proteins and the cytoplasmic ribosome have long been recognized as central players in the posttranscriptional regulation, their physical and functional interactions are still far from a complete understanding. Here, we describe the intracellular localization of Serbp1, an mRNA‐binding protein, and the inclusion of this protein in actively translating ribosomes in normal and cancer cells. These findings shed a new light into molecular mechanisms underlying Serbp1 action in translational gene regulation and tumour progression.
Acute respiratory distress syndrome caused by salicylate intoxication
Authors: Otani Yuichiro , Kanno Keishi , Toh Yoon Ezekiel Wong , Tazuma Susumu 
Published: July 2018

Key Clinical MessageSalicylate‐induced acute respiratory syndrome (ARDS) is a well‐known entity occurring in 35% of salicylate‐intoxicated patient. Careful history taking, physical examination, arterial blood gas analysis, and measurement of serum salicylate concentration will lead to early recognition to initiate appropriate treatment.
Immobilization of β‐Glucosidase BglC on Decanedioic Acid‐Modified Magnetic Nanoparticles
Authors: Wang Nuo , Wu Rina , Fu Qiang , Wang Hongling , Zhang Zheng , Haji Ze , Li Xiutong , Lian Xinglong , An Yingfeng 
Published: July 2018

Abstractβ‐Glucosidase BglC from Thermobifida fusca was efficiently immobilized on decanedioic acid‐modified magnetic nanoparticles (DMNP). Interestingly, the immobilized BglC showed much higher organic solvent stability than the free enzyme, indicating that this enzyme immobilized on DMNP should be especially suitable for catalyzing reactions in organic solvents. Additionally, the immobilized BglC also showed better thermal stability, storage stability, and mechanical stability than the free counterpart. Moreover, the reuse times were satisfactory and even crude plant materials (e.g., rice husk and corn cob) were used as substrates, which should be valuable for the decomposition of natural organic materials and the full utilization of bioresources.
Advantage of Low‐Cost Predictive Control: Study Case on a Train of Distillation Columns
Authors: Muresan Cristina I. , Ionescu Clara M. , Dulf Eva H. , Rusu-Both Roxana , Folea Silviu 
Published: July 2018

AbstractThe process of enriching the 13C isotope, performed in trains of cryogenic distillation columns, exhibits large settling times, nonlinearities, large dead‐times, and are difficult to model precisely. Such equipment has been developed in Romania, with concentration increasing up to 70 %. A control analysis for a single unit has already been done including a decentralized multivariable PI controller and two decoupling control algorithms based on the internal model control (IMC) approach. Here, a multivariable predictive controller, the extended prediction self‐adaptive controller is proposed. The simulation results, considering significant modeling errors, demonstrate that this represents a more suitable choice than the previously designed strategies. Comparisons are included to support this idea.
Hierarchically Multiporous Carbon Nanotube/Co3O4 Composite as an Anode Material for High‐Performance Lithium‐Ion Batteries
Authors: Li Xiao , Tian Xiaodong , Yang Tao , Song Yan , Liu Zhanjun 
Published: July 2018

AbstractCarbon nanotubes (CNTs) and porous Co3O4 nanorod (Co3O4 p‐NR) composites are self‐assembled to form a hierarchical porous structure through a facile hydrothermal method to meet the requirements of long cycle life, high capacity, and excellent rate capability for next‐generation lithium‐ion batteries. CNTs are embedded in Co3O4 p‐NR clusters to form a 3D conductivity network, which reduces the transportation resistance of electrons and ions. Co3O4 p‐NRs are assembled from nanoparticles, which enlarge the contact area between electrode and electrolyte to provide more space to buffer the large volumetric changes associated with repeated electrochemical reactions and maintain the structural integrity. The obtained samples exhibit a high reversible capacity (1083 mA h g−1 after 140 cycles at 0.5 Ag−1), superior rate capability (521 mA h g−1 at 8 Ag−1), and excellent cyclic stability, with a capacity decay of 0.57 mA h g−1 per cycle at a high current of 1 Ag−1 over 200 cycles. The specific heterodimensional structure gives rise to a new approach to exploit high‐performance electrode materials.
Ho‐Mediated Alkyne Reactions at Low Temperatures on Ag(111)
Authors: Hellwig Raphael , Uphoff Martin , Paintner Tobias , Björk Jonas , Ruben Mario , Klappenberger Florian , Barth Johannes V. 
Published: July 2018

AbstractLow‐temperature approaches to catalytic conversions promise efficiency, selectivity, and sustainable processes. Control over certain coupling reactions can be obtained via the pre‐positioning of reactive moieties by self‐assembly. However, in the striving field of on‐surface synthesis atomistic precision and control remains largely elusive, because the employed coupling reactions proceed at temperatures beyond the thermal stability of the supramolecular templates. Here, utilizing scanning tunneling microscopy, we demonstrate terminal alkyne on‐surface reactions mediated by Ho atoms at a weakly reactive Ag(111) substrate at low‐temperatures. Density functional theory calculations confirm the catalytic activity of the involved adatoms. Pre‐deposited Ho induces alkyne dehydrogenation starting at substrate temperatures as low as 100 K. Ho arriving at molecularly pre‐covered surfaces held at 130 and 200 K produces covalent enyne‐linked dimers and initiates cyclotrimerization, respectively. Statistical product analysis indicates a two‐step pathway for the latter, whereby the enyne intermediates influence the distribution of the products. High chemoselectivity results from the absence of cyclotetramerization and diyne‐forming homocoupling. Our analysis indicates that mainly the arriving Ho adatoms enable the coupling. These findings support the concept of dynamic heterogeneity by single‐atom catalysts and pave the way for alternative means to control on‐surface reactions.
A risk score assessment tool for peripheral arterial disease in women: From the National Health and Nutrition Examination Survey
Authors: Mansoor Hend , Elgendy Islam Y. , Williams Renessa S. , Joseph Verlin W. , Hong Young‐Rock , Mainous Arch G. 
Published: July 2018

BackgroundPeripheral arterial disease (PAD) carries a significant morbidity and mortality. Women are more commonly affected with this condition and are mostly asymptomatic, and undertreated. The objective of the study was to develop and validate a simple risk score to identify women with PAD.HypothesisIdentifying those at early stage of the disease could help reduce the risk of complications.MethodsUsing data from the National Health and Nutrition Examination Survey 1999‐2004, we identified women who had data on ankle brachial index. The cohort was divided into development (70%) and validation (30%) groups. Using variables that are self‐reported or measured without laboratory data, we developed a multivariable logistic regression to predict PAD, which was evaluated in the validation cohort.ResultsA total of 150.6 million women were included. A diagnosis of PAD was reported in 13.7%. Age, body mass index, hypertension, diabetes mellitus, smoking, non‐oral contraceptive pill usage, and parity were all independently associated with PAD. The C‐statistics was 0.74, with good calibration. The model showed good stability in the validation cohort (C‐statistics 0.73).ConclusionThis parsimonious risk model is a valid tool for risk prediction of PAD in women, and could be easily applied in routine clinical practice.