bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS)
Authors: Sundin Ulf , Østergaard Mikkel , Glinatsi Daniel , Aga Anna-Birgitte , Hørslev-Petersen Kim , Hetland Merete L. , Stengard-Pedersen Kristian , Junker Peter , Ejbjerg Bo J. , Bird Paul , Conaghan Philip G. , Lillegraven Siri , Haavardsholm Espen A. 
Published: February 2019

Objective.The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage.Methods.We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Methods included unweighted summation, normalized summation, and 3 different variants of weighted summation of the RAMRIS features. We used a derivation cohort to calculate summation weights to maximize the responsiveness of the combined score. Construct validity of the combined scores was examined by assessing correlations to imaging, clinical, and biochemical measures. Responsiveness was tested by calculating the standardized response mean (SRM) and the relative efficiency of each score in a validation cohort.Results.Patient characteristics, as well as baseline and followup RAMRIS scores, were comparable between cohorts. All combined scores were significantly correlated to other imaging, clinical, and biochemical measures. Inflammation scores combined by normalized and weighted summation had significantly higher responsiveness in comparison to unweighted summation, with SRM (95% CI) for unweighted summation 0.62 (0.51–0.73), normalized summation 0.73 (0.63–0.83), and weighted summation 0.74 (0.64–0.84). For the damage score, there was a trend toward higher responsiveness for weighted summation.Conclusion.Combined MRI scores calculated by normalized or weighted summation of individual MRI pathologies were valid and responsive.
Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)
Authors: Krabbe Simon , Eshed Iris , Gandjbakhch Frédérique , Pedersen Susanne J. , Bird Paul , Mathew Ashish J. , Lambert Robert G. , Maksymowych Walter P. , Glinatsi Daniel , Stoenoiu Maria S. , Poggenborg René , Jans Lennart , Jaremko Jacob L. , Herregods Nele , Foltz Violaine , Conaghan Philip G. , Althoff Christian E. , Paschke Joel , Peterfy Charles , Hermann Kay-Geert A. , Østergaard Mikkel 
Published: February 2019

Objective.To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis.Methods.After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0–3 separately for synovitis and osteitis, and 33 entheses 0–3 separately for soft tissue inflammation and osteitis.Results.In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35–0.77.Conclusion.Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
Establishing an Updated Core Domain Set for Studies in Juvenile Idiopathic Arthritis: A Report from the OMERACT 2018 JIA Workshop
Authors: Morgan Esi M. , Munro Jane E. , Horonjeff Jennifer , Horgan Ben , Shea Beverley , Feldman Brian M. , Clairman Hayyah , Bingham Clifton O. , Thornhill Susan , Strand Vibeke , Alongi Alessandra , Magni-Manzoni Silvia , van Rossum Marion A.J. , Vesely Richard , Vojinovic Jelena , Brunner Hermine I. , Harris Julia G. , Horton Daniel B. , Lovell Daniel J. , Mannion Melissa , Rahimi Homaira , Ravelli Angelo , Ringold Sarah , Ruperto Nicolino , Schrandt M. Suzanne , Shenoi Susan , Shiff Natalie J. , Toupin-April Karine , Tzaribachev Nikolay , Weiss Pamela , Consolaro Alessandro 
Published: February 2019

Objective.The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCT) and longitudinal observational studies (LOS) was developed without the input of patients/parents. At the Outcome Measures in Rheumatology (OMERACT) 2016, a special interest group voted to reconsider the core set, incorporating broader input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting.Methods.Candidate domains were identified through literature review, qualitative surveys, and online discussion boards (ODB) held with patients with JIA and parents in Australia, Italy, and the United States. A Delphi process with parents, patients, healthcare providers, researchers, and regulators served to edit the domain list and prioritize candidate domains. After the presentation of results, OMERACT workshop participants voted, with consensus set at > 70%.Results.Participants in ODB were 53 patients with JIA (ages 15–24 yrs) and 55 parents. Three rounds of Delphi considering 27 domains were completed by 190 (response rate 85%), 201 (84%), and 182 (77%) people, respectively, from 50 countries. There was discordance noted between domains prioritized by patients/parents compared to others. OMERACT conference voting approved domains for JIA RCT and LOS with 83% endorsement. Mandatory domains are pain, joint inflammatory signs, activity limitation/physical function, patient’s perception of disease activity (overall well-being), and adverse events. Mandatory in specific circumstances: inflammation/other features relevant to specific JIA categories.Conclusion.Following the OMERACT methodology, we developed an updated JIA Core Domain Set. Next steps are to identify and systematically evaluate best outcome measures for these domains.
Endorsement of the 66/68 Joint Count for the Measurement of Musculoskeletal Disease Activity: OMERACT 2018 Psoriatic Arthritis Workshop Report
Authors: Duarte-García Alí , Leung Ying Ying , Coates Laura C. , Beaton Dorcas , Christensen Robin , Craig Ethan T. , de Wit Maarten , Eder Lihi , Fallon Lara , FitzGerald Oliver , Gladman Dafna D. , Goel Niti , Holland Richard , Lindsay Chris , Maxwell Lara , Mease Philip , Orbai Ana Maria , Shea Beverley , Strand Vibeke , Veale Douglas J. , Tillett William , Ogdie Alexis 
Published: February 2019

Objective.The Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials and longitudinal observational studies has recently been updated. The joint counts are central to the measurement of the peripheral arthritis component of the musculoskeletal (MSK) disease activity domain. We report the Outcome Measures in Rheumatology (OMERACT) 2018 meeting’s approaches to seek endorsement of the 66/68 swollen and tender joint count (SJC66/TJC68) for inclusion in the PsA Core Outcome Measurement Set (COS).Methods.Using the OMERACT Filter 2.1 Instrument Selection Process, the SJC66/TJC68 was assessed for (1) domain match, (2) feasibility, (3) numerical sense (construct validity), and (4) discrimination (test retest reliability, longitudinal construct validity, sensitivity in clinical trials, and thresholds of meaning). A protocol was designed to assess the measurement properties of the SJC66/TJC68 joint count. The results were summarized in a Summary of Measurement Properties table developed by OMERACT. OMERACT members discussed and voted on whether the strength of the evidence supported that the SJC66/TJC68 had passed the OMERACT Filter as an outcome measurement instrument for the PsA COS.Results.OMERACT delegates endorsed the use of the SJC66/TJC68 for the measurement of the peripheral arthritis component of the MSK disease activity domain. Among patient research partners, 100% voted for a “green” endorsement, whereas among the group of other stakeholders, 88% voted for a “green” endorsement.Conclusion.The SJC66/TJC68 is the first fully endorsed outcome measurement instrument using the OMERACT Filter 2.1 and the first instrument fully endorsed within the PsA COS.
Consensus Building in OMERACT: Recommendations for Use of the Delphi for Core Outcome Set Development
Authors: Humphrey-Murto Susan , Crew Richard , Shea Beverley , Bartlett Susan J. , March Lyn , Tugwell Peter , Maxwell Lara J. , Beaton Dorcas , Grosskleg Shawna , de Wit Maarten 
Published: February 2019

Objective.Developing international consensus on outcome measures for clinical trials is challenging. The following paper will review consensus building in Outcome Measures in Rheumatology (OMERACT), with a focus on the Delphi.Methods.Based on the literature and feedback from delegates at OMERACT 2018, a set of recommendations is provided in the form of the OMERACT Delphi Consensus Checklist.Results.The OMERACT delegates generally supported the use of the checklist as a guide. The checklist provides guidance for clearly outlining the multiple aspects of the Delphi process.Conclusion.OMERACT is deeply committed to consensus building and these recommendations should be considered a work in progress.
Detection of Erosions in Sacroiliac Joints of Patients with Axial Spondyloarthritis Using the Magnetic Resonance Imaging Volumetric Interpolated Breath-hold Examination
Authors: Baraliakos Xenofon , Hoffmann Florian , Deng Xiaohu , Wang Yan-Yan , Huang Feng , Braun Juergen 
Published: February 2019

Objective.The volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique can visualize erosive cartilage defects in peripheral joints. We evaluated the ability of VIBE to detect erosions in sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA) compared to the established T1-weighted MRI sequence and computed tomography (CT).Methods.MRI (T1-weighted and VIBE) and CT scans of SIJ of 109 patients with axSpA were evaluated by 2 blinded readers based on SIJ quadrants (SQ). Erosions were defined according to Assessment of Spondyloarthritis international Society (ASAS) definitions. Scores were recorded if readers were in agreement.Results.Erosions were less frequently detected by CT (153 SQ) than by T1-weighted MRI (182 SQ; p = 0.008) and VIBE-MRI (199 SQ; p < 0.001 vs CT and p = 0.031 vs T1-weighted MRI). Taking CT as the gold standard, the sensitivity of VIBE-MRI (71.2%) was higher than that for T1-weighted MRI (63.4%), with similar specificity (87.3% vs 88%, respectively). In linear regression analysis, younger age was significantly associated with occurrence of erosions independently in VIBE-MRI (β = 0.384, p < 0.001) and T1-weighted MRI (β = 0.369, p < 0.001) compared to CT.Conclusion.The VIBE-MRI sequence was more sensitive than T1-weighted MRI in identifying erosive damage in the SIJ, especially in younger patients. This might be due to the ability of VIBE-MRI to identify structural changes in the cartilage that have not yet extended to the underlying bone, where CT seems to be superior.
Temps et moralité chez les animaux
Authors: Neira Hernán 
Published: February 2019

La communauté philosophique connaît les arguments, provenant surtout du monde anglo-saxon, qui cherchent à prouver que les animaux sont des patients mais aussi des agents moraux. Ce fait a laissé dans l’ombre la question de savoir quelle est la condition de possibilité de la morale chez les animaux ; le vécu subjectif temporel peut-il être une telle condition ? Pour y répondre, nous nous inspirons de l’œuvre de Jacob von Uexküll et concluons finalement qu’il est possible de fonder philosophiquement l’existence d’une morale animale sur l’expérience du temps.
De l’imaginaire humain à l’imaginaire des animaux. Devenirs-animaux chez Bachelard, Deleuze et Guattari, et Haraway
Authors: Dufourcq Annabelle 
Published: February 2019

Tandis que Bachelard, dans Lautréamont , étudie les transformations réelles qu’implique l’imaginaire de l’animal chez le lecteur des Chants de Maldoror et avance ainsi l’idée d’un lyrisme des corps vivants, Deleuze et Guattari rejettent la thèse selon laquelle les devenirs animaux seraient en quelque façon métaphoriques ou imaginaires. Ils sont « parfaitement réels ». Après avoir étudié les raisons justifiant chacune de ces approches, je les confronte à une troisième perspective, celle de Haraway, qui présente une lecture critique de Mille Plateaux dans When Species Meet.
Analysis of Patient-Reported Barriers to Diabetic Retinopathy Follow-Up
Authors: Lu Amanda J. , Chen Allison J. , Hwang Vicky , Law Pui Yee , Stewart Jay M. , Chao Daniel L. 
Published: February 2019

BACKGROUND AND OBJECTIVES:
Close follow-up of diabetic retinopathy (DR) has been linked to improved visual outcomes. This study elucidates patient-identified barriers to DR follow-up in a diverse urban clinic population.

PATIENTS AND METHODS:
Patients 18 years of age or older with DR or macular edema were interviewed using a 21-question survey on attitudes and barriers toward care. Univariate and multivariate logistic analysis identified barriers associated with non-compliance to follow-up.

RESULTS:
Two hundred nine patients participated with mean age of 58.2 years and hemoglobin A1c of 8.5%. The most common barriers cited were long waiting times (46.4%), other medical conditions (35.9%), forgetting (28.2%), and inability to leave work (9.1%). In a multivariate analysis, forgetting (odds ratio [OR]: 4.35) and other medical conditions (OR: 1.91) were barriers independently associated with non-compliance. Having proliferative DR was associated with other medical conditions in univariate (OR: 4.60) and multivariate analysis (OR: 4.35).

CONCLUSION:
Patients with DR who report other medical conditions or forgetting have a higher risk of non-compliance to follow-up.

[
Ophthalmic Surg Lasers Imaging Retina
. 2019;50:99–105.]
The Role of Proportional Reflux During Pars Plana Vitrectomy for Tractional Retinal Detachments
Authors: Jain Sahil , Agarwal Aniruddha , Aggarwal Kanika , Gupta Vishali 
Published: February 2019

BACKGROUND AND OBJECTIVE:
To discuss the role of proportional reflux hydrodissection (PRH) during pars plana vitrectomy (PPV) in eyes with diabetic tractional retinal detachment (TRD).

PATIENTS AND METHODS:
In this retrospective study, records of patients with diabetic TRD involving the fovea undergoing PPV with the help of PRH between January 2015 to March 2017 were noted. PRH relies on the Constellation system's proportional reflux feature. The mean age, gender, and pre- and postoperative best-corrected visual acuity (BCVA) were noted. Minimum follow-up period of 3 months was ascertained.

RESULTS:
Thirty-three patients were included. Preoperative and postoperative BCVA were 1.80 logMAR units and 1.20 logMAR units, respectively. Fifteen patients also received preoperative intravitreal ranibizumab. Twelve percent needed the help of a second instrument. Thirty-three percent developed intraoperative iatrogenic breaks, and 39.39% needed oil/gas tamponade. All patients had successful reattachments at 3-month follow-up.

CONCLUSIONS:
PRH is simple, cost-effective, surgeon-friendly, and highly controlled technique helpful in managing diabetic TRD.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:113–115.]
Choroidal Vascularity Index Using Swept-Source and Spectral-Domain Optical Coherence Tomography: A Comparative Study
Authors: Agrawal Rupesh , Seen Sophia , Vaishnavi Shiva , Vupparaboina Kiran Kumar , Goud Abhilash , Rasheed Mohammed Abdul , Chhablani Jay 
Published: February 2019

BACKGROUND AND OBJECTIVE:
Choroidal vascularity index (CVI) is a noninvasive tool to assess choroidal structure. The objective of the current study was to compare the CVI measurements on swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) scans using the same image binarization protocol.

PATIENTS AND METHODS:
This prospective study was conducted from July 2016 through January 2017 and involved 54 healthy volunteers at a tertiary referral eye care institute in Southern India. Choroidal scans were obtained using both SS- and SD-OCT machines. An automated binarization algorithm was used to compute CVI.

RESULTS:
The mean CVI with SS-OCT scans was 53.88% ± 12.54% (range: 20.46% to 73.93%), whereas the mean CVI with SD-OCT scans was 51.11% ± 7.97% (range: 29.90% to 67.72%)(P < .001). The unadjusted (95% confidence interval [CI], 0.554–0.851) and adjusted (95% CI, 0.607–0.871) intraclass correlation (ICC) estimates were quite similar and indicate moderate-to-good reliability of measurements by two machines. The interval estimate for a conversion factor between SD-OCT and SS-OCT can be calculated as follows: SD = [0.383*SS+19.467, 0.586*SS+30.661].

CONCLUSION:
CVI is a noninvasive, robust, and reliable measurement of choroidal vascularity and CVI measurements obtained using both SS-OCT and SD-OCT concur with each other.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:e26–e32.]
Le silence des anneaux : une tentative de reconstitution d’une chaîne opératoire de fabrication d’anneaux en os
Authors: Khan Bénédicte , Picod Christophe 
Published: February 2019

Au Proche-Orient hellénistique et romain, des anneaux en os et en écaille de tortue sont produits à partir de plaquettes quadrangulaires. Cette production par plaquettes a soulevé des interrogations quant à sa réalisation. Cet article présente une reconstitution de sa chaîne opératoire de fabrication. Certaines séquences ont été déduites de l’étude des stigmates visibles sur les rejets artisanaux ; d’autres découlent des connaissances sur l’outillage aux époques étudiées et de la mise en pratique de techniques lors de l’expérimentation.
Genèse et histoire éditoriale d’un manuscrit inconnu d’Aimé Césaire
Authors: Arnold Albert James 
Published: February 2019

Le 18 mai 2018, à la bibliothèque Wren de Trinity College à Cambridge, le vernissage de l’exposition « Wifredo Lam : Livres d’artistes » a réservé une heureuse surprise aux spécialistes du poète présents. On a pu lire, sur deux feuilles manuscrites à en-tête de l’Assemblée Nationale, un texte qui commence par « Des pays intenses, où la force créatrice, jamais épuisée… ». De prime abord, on aurait dit un premier état de « Wifredo Lam et les Antilles », que les Cahiers d’art ont publié sous le titre « Wifredo Lam » dans leur numéro double (20-21) au dernier trimestre de 1946. La biobibliographie assurée par K. Véron et T. Hale en 2013 nous confirme cependant qu’il s’agit du manuscrit autographe de la contribution que Césaire avait offerte pour le catalogue de l’œuvre de Lam exposée au Musée des Beaux-Arts de Caracas, au Venezuela, du 8 au 22 mai 1955.
Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes
Authors: Ramirez-Carrozzi Vladimir , Ota Naruhisa , Sambandam Arivazhagan , Wong Kit , Hackney Jason , Martinez-Martin Nadia , Ouyang Wenjun , Pappu Rajita 
Published: February 2019

Abstract
IL-17 family cytokines are critical to host defense responses at cutaneous and mucosal surfaces. Whereas IL-17A, IL-17F, and IL-17C induce overlapping inflammatory cascades to promote neutrophil-mediated immunity, IL-17E/IL-25 drives type 2 immune pathways and eosinophil activity. Genetic and pharmacological studies reveal the significant contribution these cytokines play in antimicrobial and autoimmune mechanisms. However, little is known about the related family member, IL-17B, with contrasting reports of both pro- and anti-inflammatory function in rodents. We demonstrate that in the human immune system, IL-17B is functionally similar to IL-25 and elicits type 2 cytokine secretion from innate type 2 lymphocytes, NKT, and CD4+ CRTH2+ Th2 cells. Like IL-25, this activity is dependent on the IL-17RA and IL-17RB receptor subunits. Furthermore, IL-17B can augment IL-33–driven type 2 responses. These data position IL-17B as a novel component in the regulation of human type 2 immunity.
Identification of Two Nonrearranging IgSF Genes in Chicken Reveals a Novel Family of Putative Remnants of an Antigen Receptor Precursor
Authors: Fu Yanbin , Yang Zhi , Huang Jinwei , Cheng Xueqian , Wang Xifeng , Yang Shiping , Ren Liming , Lian Zhengxing , Han Haitang , Zhao Yaofeng 
Published: February 2019

Abstract
In this study, we identified a pair of nonrearranging VJ-joined Ig superfamily genes, termed putative remnants of an Ag receptor precursor (PRARP) genes, in chicken. Both genes encode a single V-set Ig domain consisting of a canonical J-like segment and a potential immunoreceptor tyrosine-based inhibitory or switch motif in the cytoplasmic region. In vitro experiments showed that both genes were expressed at the cell surface as membrane proteins, and their recombinant products formed a monomer and a disulfide-linked homodimer or a heterodimer. These two genes were mainly expressed in B and T cells and were upregulated in response to stimulation with poly(I:C) in vitro and vaccination in vivo. Orthologs of PRARP have been identified in bony fish, amphibians, reptiles, and other birds, and a V-C1 structure similar to that of Ig or TCR chains was found in all these genes, with the exception of those in avian species, which appear to contain degenerated C1 domains or divergent Ig domains. Phylogenetic analyses suggested that the newly discovered genes do not belong to any known immune receptor family and appear to be a novel gene family. Further elucidation of the functions of PRARP and their origin might provide significant insights into the evolution of the immune system of jawed vertebrates.
Inconsistencies between observed, reconstructed, and simulated precipitation indices for England since the year 1650 CE
Authors: Bothe Oliver , Wagner Sebastian , Zorita Eduardo 
Published: February 2019

Abstract. The scarcity of long
instrumental records, uncertainty in reconstructions, and insufficient skill
in model simulations hamper assessing how regional precipitation changed over
past centuries. Here, we use standardized precipitation data to compare a
regional climate simulation, reconstructions, and long observational records
of seasonal (March to July) mean precipitation in England and Wales over the
past 350 years. The Standardized Precipitation Index is a valuable tool for
assessing agreement between the different sources of information, as it
allows for a comparison of the temporal evolution of percentiles of the
precipitation distributions. These evolutions are not consistent among
reconstructions, a regional simulation, and instrumental observations for
severe and extreme dry and wet conditions. The lack of consistency between
the different data sets may be due to the dominance of internal climate
variability over the impact of natural exogenous forcing conditions on
multi-decadal timescales. The disagreement between sources of information
reduces our confidence in inferences about the origins of hydroclimate
variability for small regions. However, it is encouraging that there is still
some agreement between a regional simulation and observations. Our results
emphasize the complexity of hydroclimate changes during the recent centuries
and stress the necessity of a thorough understanding of the processes
affecting forced and unforced precipitation variability.