bluuebunny/crossref_metadata_2025_split huggingface dataset:
MURABAHAH FINANCING AND EFFECT ON EARNINGS IJARAH BCA ISLAMIC YEAR 2012-2015
Authors: Arwani Agus , Wakhidin Muhammad 
Published: March 2019

Financing as an important element in the bank. Based on data from Bank Indonesia, the loan product most in demand is Murabaha, which is financed with the principle of buying and selling. The purpose of this study was to determine the effect or not the financing Murabaha, Ijarah partially and simultaneously to profit BCA Syariah years 2012-2015.This type of research correlation with a quantitative approach.. The data source of monthly financial reports from January 2012 to December of 2015. The analysis of the data by t-test indicates that the variable Murabaha financing with significant influence on profits of less than 5% is equal to 0.000 and for Ijarah variable has no effect on earnings by more than 5% significance that is equal to 0.374. Based on the test results F it can be concluded that the financing Murabaha and Ijarah effect on profits, it is based on the calculation of the value of the F test of significance smaller than the significance level of 5% IE 0,000. The ability to predict the independent variable on the dependent variable is equal to 59.1% is indicated by the Adjusted R Square of 59.1%, while the remaining 40.9% is influenced by other variables.Keywords: Earnings, Murabahah, Ijarah
A web-based adapted physical activity program (e-APA) versus health education program (e-HE) in patients with schizophrenia and healthy volunteers: study protocol for a randomized controlled trial (PEPSY V@Si)
Authors: Tréhout Maxime , Leroux Elise , Bigot Lucile , Jego Solenne , Leconte Pascal , Reboursière Emmanuel , Morello Rémy , Chapon Pierre-Alexandre , Herbinet Aline , Quarck Gaëlle , Dollfus Sonia 
Published: March 2019

Abstract
Background Patients with schizophrenia (SZ) present a higher level of cardiovascular morbidity than the general population due to poor physical fitness and a sedentary lifestyle. Moreover, despite major therapeutic advances in the management of SZ, some clinical symptoms remain resistant to pharmacological approaches. A large number of studies support the effectiveness of physical activity (PA) for both physical and mental health in SZ. The main objective of the present study is to assess the effects of a remote, web-based adapted PA program (e-APA) compared to a health education program (e-HE) on brain plasticity in SZ and healthy volunteers (HV). The secondary objectives are to assess the effects of e-APA on other cerebral variables as well as clinical, neurocognitive, circadian, biological, and physiological variables. Methods: The study is an interventional, multicenter, randomized open-label controlled trial. Forty-two SZ will be randomized to either the active group (e-APA, N = 21) or non-active group (e-HE, N = 21), and 42 HV will be matched to SZ according to age, gender, and level of PA. Interventions will consist of 32 sessions (2x60 minutes/week, for 16 weeks) via supervised home-based videoconferencing. The active group will carry out an individualized PA program of moderate to vigorous intensity. Pre- and post-intervention cerebral magnetic resonance imaging (MRI) will be performed to evaluate changes in global hippocampal volume. Other cerebral assessments using diffusion tensor imaging, arterial spin labelling, spectroscopy and resting-state functional MRI will be performed. In addition, clinical, neurocognitive and circadian rhythms assessments as well as physical tests and biological analyses will be conducted. Discussion: To our knowledge, this is the first study aiming to evaluate the efficacy of APA delivered by supervised home-based videoconferencing in SZ. Moreover, using multimodal MRI, this study could clarify the pathophysiological mechanisms underlying the efficacy of APA. Finally, this innovative approach (remote, web-based APA) might also increase participation in long-term PA since PA-based programs are known to have low adherence and early dropout. The results of this study should promote the inclusion of PA interventions as a novel adjunctive therapy for SZ. Trial registration: ClinicalTrials.gov identifier: NCT03261817. Registered on 16 August 2017.
Aktywna obserwacja raka gruczołu krokowego w oparciu o doniesienia z konferencji ESTRO nr 35 w Turynie.
Authors: Burchardt Wojciech 
Published: March 2019

Rak gruczołu krokowego(RGK) dotyczy coraz większej liczby mężczyzn w Polsce. Zwiększenie dostępności do badania stężenia antygenu sterczowego (PSA) i większa świadomość społeczeństwa doprowadziła do wykrywania choroby u pacjentów bezobjawowych we wczesnym stadium. Skutkiem wczesnego wykrycia RGK jest możliwość zastosowania wielu opcji terapeutycznych. Jednakże u części chorych z RGK wprowadzenie leczenia nie wydłuży życia i nie poprawi jego jakości, a nawet ją obniży ze względu na skutki uboczne. Grupa chorych o niskim zaawansowaniu największy zysk terapeutyczny odnosi z aktywnej obserwacji (AO).AO to postępowanie oparte na monitorowaniu zaawansowania klinicznego, biochemicznego i histopatologicznego w celu uniknięcia leczenia lub jego odroczenia. Mimo wielu zalet i bezpieczeństwa, jest nadal bardzo rzadko stosowana w Polsce. Celem pracy jest przedstawienie doniesień z konferencji Europejskiego Towarzystwa Radioterapii Onkologicznej ( ESTRO ) w Turynie w 2016 roku na temat AO. W trakcie konferencji omówiono postępowanie AO z punktu widzenia patologa , radiologa i onkologa. Podsumowując , AO jest postępowaniem bezpiecznym, obarczonym niskim ryzykiem skutków ubocznych,a także ekonomicznie uzasadnionym u dobrze dobranych chorych.
Początki medycyny nuklearnej w Europie. The development of Nuclear Medicine in Europe.
Authors: Pietrzak Agata Karolina , Nadolny Filip , Cholewiński Witold 
Published: March 2019

Artykuł przedstawia początki Medycyny Nuklearnej jako jednej najintensywniej ewoluujących dziedzin medycyny, fizyki, chemii oraz inżynierii medycznej. Europejska medycyna nuklearna, ze względu na podłoże historyczne i polityczne, mające duży wpływ na kształtowanie się wszystkich gałęzi nauki na kontynencie, należy bez wątpienia do jednego najciekawszych wątków w medycynie światowej. Złożoność genezy i ewolucji medycyny nuklearnej stanowi doskonały przykład kreatywności europejskich badaczy.This article describes Nuclear Medicine as one of most intensively developing medical, physical, chemical and engineering field of science. European Nuclear Medicine as undoubtedly one of most interesting topics in the medical world, deserves closer attention because of its complex historical and political origin which had great influence on establishing the branch of science on the continent.
„Wokół radioterapii miednicy - sprawozdanie z ESTRO 35 w Turynie” „Focus on the pelvic region – report of the conference ESTRO 35 in Turin”
Authors: Czajka Elżbieta 
Published: March 2019

Realizując panel wystąpień ustnych „Focus on the pelvic region” podczas konferencji ESTRO 35 poruszono trzy tematy związane z leczeniem nowotworów regionu miednicy: śledzeniu ruchomości prostaty z użyciem złotych markerów GoldAnchor, wpływie wypełnienia pęcherza moczowego na napromienianie narządów miednicy oraz ewaluacji narzędzia internetowego Treatmentchoice, służącego do wspólnego podejmowania decyzji terapeutycznej w raku gruczołu krokowego. Niniejsza praca ma za zadanie przybliżenie czytelnikowi tematyki poruszanej podczas konferencji oraz zwrócenie uwagi na różnorodność wyzwań, jakie stawia przed zespołem terapeutycznym radioterapia narządów miednicy. During the „Focus on the pelvic region” panel on ESTRO 35 conference three topics were discussed : tracking prostate movement with GoldAnchor fiducials, effect of bladder filling on the radiotherapy of the pelvic region and evaluation of Decision Aid Tool for prostate cancer – Treatmentchoice. This work is intended to bring the reader closer to the subject matter of the conference and to highlight the variety of challenges that the pelvic radiotherapy team is facing.
Emerging Research Paradigm for Infant Drug Exposure Through Breast Milk
Authors: Ito Shinya 
Published: March 2019

Background:
Information on drug secretion into milk is insufficient due to the exclusion of lactating
women from clinical trials and drug development processes. As a result, non-adherence to the necessary drug
therapy and discontinuation of breastfeeding occur, even if the predicted level of infant exposure is low. In contrast,
inadvertent infant exposure to drugs in breast milk continues to happen due to lack of rational risk assessment,
resulting in serious toxicity cases including death. This problem is multifactorial, but one of the key elements
is the lack of pharmacokinetic information on drug secretion into milk and resultant infant exposure levels,
the first line of evidence for risk assessment.

Methods:
Basic PK principles in drug excretion into milk were explained. The literature was scanned to identify
approaches for PK data acquisition in this challenging field.

Results:
This review describes the feasibility to develop such approaches, and the knowledge gaps that still exist.
A combination of population pharmacokinetics approach (to estimate averages and variations of drug concentration
profiles in milk) and physiologically-based pharmacokinetics modeling of infants (to predict the population
profiles of infant drug exposure levels) appears useful.

Conclusions:
In order to facilitate participant enrollment and PK data acquisition in a timely manner, networks of
investigators become crucial.
Current Status of Used Protocols for Mesenchymal Stem Cell Differentiation: A Focus on Insulin Producing, Osteoblast-Like and Neural Cells
Authors: Rajabi Hadi , Hosseini Vahid , Rahimzadeh Sevda , Seyfizadeh Nayer , Aslani Somayeh , Abhari Alireza 
Published: March 2019

:
Mesenchymal stem cells (MSCs) have attracted a great deal of interest in the field of regenerative
medicine because of their ability to differentiate into mesodermal derivatives and even other germ
layers. The main requirement for better differentiation of MSCs into desired cell lineage is relied on pure
population of these cells. During the past years, significant progresses have been developed for the identification
of MSCs by introducing new markers or different combination of markers. Currently, direct in
vitro differentiation protocols using standard media supplemented with specific growth factors generating
osteoblast, insulin producing and neuron cells from MSCs show some key characteristic in in vivo counterparts.
However, these efforts should be continued to achieve high amount of fully differentiated cells
which have high capacity to be used in cell based therapies and drug screening. This review focuses on
common culture based differentiation strategies used for osteoblast, insulin producing cells and neural
cells generation from MSCs highlighting important findings and trends in this exciting area.
Modelling Deaths Associated with Road Traffic Accidents and other Factors on Great North Road in Zambia between the Years 2010 and 2016 Using Poisson Models
Authors: Fisa Ronald , Nakazwe Chola , Michelo Charles , Musonda Patrick 
Published: March 2019

Background:
According to the World Health Organization (WHO), 1.24 million people die annually on the world’s roads, with 20-50 million sustaining non-fatal injuries. More than 85% (1.05 million) of the global deaths due to injuries occur in the developing world. Road traffic deaths and injuries are a major but neglected public health challenge that requires concerted efforts for effective and sustainable prevention. The objectives of the study were to estimate the incidence rate of death from RTAs, to determine factors associated with serious and fatal Road Traffic Accidents (RTAs) and to determine which of the poisson models fit the count data better.

Methods:
Data was collected from Zambia Police (ZP), Traffic Division on accidents that occurred on the Great North Road (GNR) highway between Lusaka and Kapiri-Mposhi in Zambia from January 1, 2010 to December 31, 2016. Results from standard Poisson regression were compared to those obtained using the Negative Binomial (NB), Zero-Truncated Negative Binomial (ZTNB) and the Zero-Truncated Poisson (ZTP) regression models. Diagnostic tests were used to determine the best fit model. The data was analysed using STATA software, version 14.0 SE (Stata Corporation, College Station, TX, USA).

Results:
A total of 1, 023 RTAs were analysed in which 1, 212 people died. Of these deaths, 82 (7%) were Juveniles and 1, 130 (93%) were adults. Cause of accident such as pedestrians crossing the road accounted for 30% (310/1,023) while 29% (295/1,023) were as a result of driver’s excessive speed. The study revealed that driving in the early hours of the day (1AM-6AM) as compared to driving in the night (7PM-12AM) had a significant increase in the incidence rate of death from RTAs, Incidence Rate Ratio (IRR) of 2.1, (95% CI={1.01-4.41}), p-value=0.048. Results further showed that public transport as compared to private transport had an increased incidence rate of death from RTAs (IRR=5.65, 95% CI={2.97-10.73}), p-value<0.0001. The two competing models were the ZTP and the ZTNB. The ZTP had AIC=1304.55, BIC= 1336.55, whereas the ZTNB had AIC=742.25 and BIC=819.69. This indicated that the ZTNB with smaller AIC and BIC was the best fit model for the data.

Conclusion:
There is a reduced incidence of dying if one is using a private vehicle as compared to a public vehicle. Driving in the early hours of the day (1AM and 6AM) had an increased incidence of death from RTAs. This study suggests that when dealing with counts in which there are a few zeros observed such as in serious and fatal RTAs, ZTNB fits the data well as compared to other models.
The Determinants of Delayed Diagnosis and Treatment Among Malaria Patients in Myanmar: A Cross-Sectional Study
Authors: Than Myo Min , Min Myo , Aung Pyae Linn 
Published: March 2019

Background:This cross-sectional study was conducted to assess the determining factors for delayed diagnosis and treatment among malaria patients in Myanmar.Methods:The sample comprised 220 respondents diagnosed with malaria last year, living in the upper, middle, and lower part of Myanmar. In 2017, data were collected through interviews and analyzed using percentage, mean, standard deviation, and the chi-square test.Results:The results affirmed that most of the respondents were in the working age group and of low educational level. They also had poor knowledge and perception of malaria, and more than half of the respondents visited health centers or volunteered for their first treatment of choice. Most respondents received little social support for malaria. There were significant associations between age, sex, education, marital status, occupation, and delayed diagnosis and treatment (p < 0.05). Knowledge and perceptions of malaria, health-seeking behavior, and low social support on malaria services were also significantly associated with delayed malaria diagnosis and treatment (p < 0.05).Conclusion:According to the findings, appropriate strengthening of cooperation and collaborations among different sectors upon diagnosis, coverage of treatment services, interventions to increase community awareness, effective communication, behavioral changes, and improved capability of the village health volunteers are evidently needed.
Overexpression of microRNA-21 in the Serum of Breast Cancer Patients
Authors: Savari Batool , Boozarpour Sohrab , Tahmasebi-Birgani Maryam , Sabouri Hossein , Hosseini Seyed Mohammad 
Published: March 2019

Background:
Breast cancer is the most common cancer diagnosed in women worldwide.
So it seems that there's a good chance of recovery if it's detected in its early stages even before the
appearances of symptoms. Recent studies have shown that miRNAs play an important role during
cancer progression. These transcripts can be tracked in liquid samples to reveal if cancer exists, for
earlier treatment. MicroRNA-21 (miR-21) has been shown to be a key regulator of carcinogenesis,
and breast tumor is no exception.

Objective:
The present study was aimed to track the miR-21 expression level in serum of the breast
cancer patients in comparison with that of normal counterparts.

Methods:
Comparative real-time polymerase chain reaction was applied to determine the levels of
expression of miR-21 in the serum samples of 57 participants from which, 42 were the patients with
breast cancer including pre-surgery patients (n = 30) and post-surgery patients (n = 12), and the others
were the healthy controls (n = 15).

Results:
MiR-21 was significantly over expressed in the serum of breast cancer patients as compared
with healthy controls (P = 0.002). A significant decrease was also observed following tumor resection
(P < 0.0001). Moreover, it was found that miR-21 overexpression level was significantly associated
with tumor grade (P = 0.004).

Conclusion:
These findings suggest that miR-21 has the potential to be used as a novel breast cancer
biomarker for early detection and prognosis, although further experiments are needed.
Неоднородные процессы инжекции и теплопереноса в реверсивно-включаемых динисторах при работе в частотно-импульсных режимах с ограниченным теплоотводом
Authors: Горбатюк А.В. , Иванов Б.В. 
Published: March 2019

AbstractFor the first time, a self-consistent computational–theoretical description of the physical processes in reversely switched dynistors (RSDs) is obtained when operating in pulse-frequency modes with a limited heat sink. A simplified representation of the nonlinear multiscale mechanism of interaction between the injection and heat-transfer subsystems is substantiated, and a method for calculating the maximum frequency of the RSD switching unit is developed on this basis. The dependence of the permissible frequency on the cooler power is calculated for the set parameters of the chip and the shape of the switched pulses. It is shown that, with a proper heat sink, each from all RSD modules with a chip area of 1 cm^2 and an operating voltage of U ≈ 2.5 kV are able to switch an energy of 0.25 J per pulse with a repetition frequency of up to 30 kHz. For high-voltage generators on their basis with U ≈ 100 kV, the power transmitted to a load at this frequency amounts to several fractions of a MW.
ENHANCING STUDENTS’ SPEAKING ABILITY AT 10TH GRADE OF COMPUTER AND NETWORK ENGINEERING CLASS AT SMKN 4 MALANG THROUGH L1/L2 BASED STRATEGIES
Authors: Junaida Rizki , Prastiyowati Santi 
Published: March 2019

The lack of speaking practice will cause some communication problems. When language learners do not know how to say a word in English, they can communicate effectively by using their hands, imitating sounds, using new words, or describing what they mean. Those ways can be done by the studentsas communication strategies. This research is aimed to describe the enhancement of students’ speaking ability at Computer and Network Engineering Class C of SMKN 4 Malang by using L1/ L2 based strategies. This Class Action Research (CAR) was conducted at SMKN 4 Malang. The subjects of this research were the students of thenth-grade of Computer and Network Engineering Class C, which consisted of 33 students. This classroom action research was conducted through the following procedures: preliminary observation, planning, implementing, observation, and reflection. There were two major indicators used as the criteria of success in this research. First, mean score of the post test was ≥ 75. Second, there should be 50% of students get score ≥ 75. Before conducting this research, a preliminary study was conducted to know the students’ problem in speaking skill. The result of the speaking test in preliminary study showed that the mean score of 33 students was 64.8. There were only 7 students who got score ≥ 75. In Cycle I, L1/L2 based strategy showed the improvement of students’ speaking. The mean score of Cycle I was 67.5. The Cycle 1 failed because the students who got ≥ 75 were only 6 students which were consisting of 21%. However, the mean score of Cycle II was 78.6. It means that the first criterion of success was achieved. Moreover, the students who got score ≥75 were 75.9%. Therefore, the all criteria of success were achieved. To sum up, the result of classroom action research proved that L1/L2 based strategies could enhance speaking ability at 10th Grade of Computer and Network Engineering Class C at SMKN 4 Malang.
TEACHING ENGLISH WITH STORY TELLING METHOD IN EARLY CHILDHOOD EDUCATION TEACHERS
Authors: Amalia Arsyi Rizqia 
Published: March 2019

The importance of English has an impact on the needs of future generations to learn English from an early age especially in Early Childhood Education and vocabulary is an important component that can support the mastery of all four language skills. Facing the difficulty of learning vocabulary, a method that is appropriate for the age of child development is needed. One of methods that could be used is story telling. The research method used in this research is qualitative descriptive. The sample in this study was six early childhood education teachers in Sukabumi. Data collecting techniques were presentations and questionnaires. The presentations were held twice, in front of peers of early childhood education teachers and in front of students of early childhood education. After presentation, the questionnaires were conducted related to the implementation of the story telling method to the teacher. Based on the data collected, Teaching English with Story Telling Method give a good response with indicators shows that the content of the story, the properties used, the variety of vocabulary taught, moral values based on the stories and the ability of delivering the English vocabulary were good and suitable with the age of early childhood education.
METODE INKUIRI BERBANTUAN MEDIA BENDA KONKRET DALAM MENINGKATKAN HASIL BELAJAR MATEMATIKA SISWA SEKOLAH DASAR
Authors: Ekajana I Kadek Suputra , Sujana I Gede 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar Matematika setelah diberikan tindakan berupa Penerapan Metode Inkuiri Berbantuan Media Benda Konkret dalam pembelajaran matematika siswa kelas III Semester 2 dengan jumlah siswa 10 orang, dengan jumlah siswa laki-laki 4 orang dan siswa perempuan 6 orang di SDN 6 Tianyar, Kecamatan Kubu, Kabupaten Karangasem, diantaranya terdapat 5 orang siswa yang mengalami hasil belajar rendah yaitu dibawah standar yang ditetapkan. Data hasil belajar yang telah terkumpul dianalisis dengan metode statistik diskriptif kuantitatif. Hasil penelitian ini menunjukan bahwa dengan penggunaan Metode Inkuiri Berbantuan Media Benda Konkret pada siswa kelas III Semester 2 SDN 6 Tianyar dapat meningkatkan hasil belajar siswa dari rata-rata kelas 50% (kurang) sebelum tindakan, setelah tindakan pada siklus I rata-rata nilai kelas adalah 54,6% (cukup). Besar peningkatan sebelum tindakan dan setelah tindakan pada siklus I sebesar 15% sedangkan nilai rata-rata kelas pada siklus II adalah 73,8,% (Baik). besar peningkatan dari siklus I dan siklus II sebesar 19,2% ini menunjukkan ada peningkatan dari siklus I dan siklus II dari kategori cukup menjadi kategori baik.