bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive aspergillosis of the sphenoethmoidal sinuses in an immunocompetent host
Authors: Johnson Curtis D. , Brandes Warren 
Published: February 2019

Abstract
Fungal infections of the nose and paranasal sinuses are uncommon; Aspergillus is the most frequently isolated fungal pathogen. Invasive aspergillosis is commonly seen as an opportunistic infection in the immunocompromised, debilitated host. Whereas fulminant infection in the otherwise healthy patient is rare, in the immunocompetent host with persistent signs and symptoms of sinusitis despite appropriate medical management, aspergillosis should be considered. Treatment of paranasal sinus aspergillosis requires correction of immunologic deficits, if possible; aggressive surgical debridement to provide adequate drainage and aeration of the sinuses; and adjunctive antifungal chemotherapy. The authors present an unusual case of invasive aspergillosis of the paranasal sinuses in fin immunocompetent host.
Membrane potential (Vmem) measurements during mesenchymal stem cell (MSC) proliferation and osteogenic differentiation
Authors: Bhavsar Mit Balvantray , Cato Gloria , Hauschild Alexander , Leppik Liudmila , Costa Oliveira Karla Mychellyne , Eischen-Loges Maria José , Barker John Howard 
Published: February 2019

Background
Electrochemical signals play an important role in cell communication and behavior. Electrically charged ions transported across cell membranes maintain an electrochemical imbalance that gives rise to bioelectric signaling, called membrane potential or Vmem. Vmem plays a key role in numerous inter- and intracellular functions that regulate cell behaviors like proliferation, differentiation and migration, all playing a critical role in embryonic development, healing, and regeneration.

Methods
With the goal of analyzing the changes in Vmem during cell proliferation and differentiation, here we used direct current electrical stimulation (EStim) to promote cell proliferation and differentiation and simultaneously tracked the corresponding changes in Vmem in adipose derived mesenchymal stem cells (AT-MSC).

Results
We found that EStim caused increased AT-MSC proliferation that corresponded to Vmem depolarization and increased osteogenic differentiation that corresponded to Vmem hyperpolarization. Taken together, this shows that Vmem changes associated with EStim induced cell proliferation and differentiation can be accurately tracked during these important cell functions. Using this tool to monitor Vmem changes associated with these important cell behaviors we hope to learn more about how these electrochemical cues regulate cell function with the ultimate goal of developing new EStim based treatments capable of controlling healing and regeneration.
Predictors of foot care behaviours in patients with diabetes in Turkey
Authors: Yıldırım Usta Yasemin , Dikmen Yurdanur , Yorgun Songül , Berdo İkbal 
Published: February 2019

Background
The management of diabetic foot complications is challenging, time-consuming and costly. Such complications frequently recur, and the feet of individuals with diabetes can be easily infected. The variables that predict foot care behaviours must be identified to improve foot care attitudes and behaviours. Thus, this study aimed to evaluate the predictors of foot care behaviours in individuals with diabetes and the role of these variables.

Methods
This descriptive and analytic study was carried out between July 2015 and July 2016, and 368 outpatients with diabetes from a public hospital in Turkey were included. The participants had no communication, psychiatric or neurological problems and had been diagnosed with diabetes for at least 1 year. Foot care behaviour was the dependent variable and was evaluated with the foot care behaviour questionnaire. The relationship among foot care behaviours and sociodemographic characteristics, diabetes-related attitudes, disease perception, health beliefs and perceived social support was evaluated. Factors that independently predicted effective foot care behaviours were estimated via a linear regression analysis.

Results
The foot care behaviour score of the participants was above average (54.8 ± 5.0). Gender (t = −2.38, p = 0.018), history of a foot wound (t = −2.74, p = 0.006), nephropathy (t = 3.13, p = 0.002), duration subscale of the illness perception scores (t = 2.26, p = 0.024) and personal control subscale of the health belief scores (t = −2.07, p = 0.038) were significant predictors of foot care behaviours. These variables, which provided model compatibility, accounted for approximately 22.0% of the total variance of the foot care behaviour score (R = 0.47, R2 = 0.22, F = 5.48, p ≤ 0.001).

Discussion
Our results show factors that may affect diabetic foot care behaviours. Several of these factors prevent individuals from practising these behaviours. Further studies on the roles of barriers as predictors of foot care behaviours must be conducted.
The detailed distribution of T cell subpopulations in immune-stable renal allograft recipients: a single center study
Authors: Zhuang Quan , Peng Bo , Wei Wei , Gong Hang , Yu Meng , Yang Min , Liu Lian , Ming Yingzi 
Published: February 2019

Background
Most renal allograft recipients reach a stable immune state (neither rejection nor infection) after transplantation. However, the detailed distribution of overall T lymphocyte subsets in the peripheral blood of these immune-stable renal transplant recipients remains unclear. We aim to identify differences between this stable immune state and a healthy immune state.

Methods
In total, 103 recipients underwent renal transplantation from 2012 to 2016 and received regular follow-up in our clinic. A total of 88 of these 103 recipients were enrolled in our study according to the inclusion and exclusion criteria. A total of 47 patients were 1 year post-transplantation, and 41 were 5 years post-transplantation. In addition, 41 healthy volunteers were recruited from our physical examination clinic. Detailed T cell subpopulations from the peripheral blood were assessed via flow cytometry. The parental frequency of each subset was calculated and compared among the diverse groups.

Results
The demographics and baseline characteristics of every group were analyzed. The frequency of total T cells (CD3+) was decreased in the renal allograft recipients. No difference in the variation of the CD4+, CD8+, and activated (HLA-DR+) T cell subsets was noted among the diverse groups. Regarding T cell receptor (TCR) markers, significant reductions were found in the proportion of γδ T cells and their Vδ2 subset in the renal allograft recipients. The proportions of both CD4+ and CD8+ programmed cell death protein (PD) 1+ T cell subsets were increased in the renal allograft recipients. The CD27+CD28+ T cell proportions in both the CD4+ and CD8+ populations were significantly decreased in the allograft recipients, but the opposite results were found for both CD4+ and CD8+ CD27-CD28- T cells. An increased percentage of CD4+ effector memory T cells and a declined fraction of CD8+ central memory T cells were found in the renal allograft recipients.

Conclusion
Limited differences in general T cell subsets (CD4+, CD8+, and HLA-DR+) were noted. However, obvious differences between renal allograft recipients and healthy volunteers were identified with TCR, PD1, costimulatory molecules, and memory T cell markers.
Status of the Cultural Heritage Sites and Structures in Camalig, Province of Albay, Philippines: Basis for Sustainable Tourism Framework
Authors: Gonzales Maria Luisa N. 
Published: February 2019

Cultural heritage is the legacy of physical artifacts, and intangible attributes of a group or club that are inherited from past generations kept up in the present and preserved for the welfare of future generations. It aimed to determine the natural and human-made attractions, its status along preservations, promotions, and Local Government unit contributions, the problems encountered and solutions recommended. The study used the descriptive-correlational method of research by employing questionnaires, interviews and documentation of the structures and site to the 5 facilitators, 24 residents and 31 tourists in the community with 60 respondents and used the frequency distributions, percent count, weighted mean and the coefficient of concordance W. Data revealed that the heritage sites and structures were in the form of Natural Attractions and Man-Made attractions and presently considered much preserved, very much promoted with LGU Contribution as much effect, while, there was no significant agreement between the three groups of respondents along the status, and the null hypothesis was rejected. The problems encountered were much pressing, and solutions recommended as very much urgent. Thus, this research will provide to the understanding of the factors associating to the sustainability of the Heritage Site and Structure of a particular locality that can lead to goal fulfillment and, subsequently, impact tourism choice.
Assessing lek attendance of male greater sage‐grouse using fine‐resolution GPS data: Implications for population monitoring of lek mating grouse
Authors: Wann Gregory T. , Coates Peter S. , Prochazka Brian G. , Severson John P. , Monroe Adrian P. , Aldridge Cameron L. 
Published: February 2019

AbstractCounts of males displaying on breeding grounds are the primary management tool used to assess population trends in lekking grouse species. Despite the importance of male lek attendance (i.e., proportion of males on leks available for detection) influencing lek counts, patterns of within season and between season variability in attendance rates are not well understood. We used high‐frequency global positioning system (GPS) telemetry data from male greater sage‐grouse (Centrocercus urophasianus; n = 67) over five lekking seasons (2013–2017) at eight study sites in Nevada to estimate lek attendance rates. Specifically, we recorded daily locations of sage‐grouse in relation to mapped lek boundaries and used generalized additive models to assess temporal variation in attendance rates by age class (subadult vs. adult). Average timing of peak attendance occurred on 16 April but varied from March 16, 2014 to April 21 , 2016. Overall, adult males attended leks at higher rates (0.683 at peak) and earlier in the season (19 March) than subadults (0.421 at peak on April 19). Peak attendance probability was positively related to cumulative winter precipitation. Daily probabilities of lek switching differed between adults (0.019 at peak on March 3) and subadults (0.046 at peak on March 22), and lek switching was negatively related to distance to nearest lek. Our results indicate variable patterns in lek attendance through time, and that lek switching may occur at higher rates than previously thought. We demonstrate the use of generalizable daily attendance curves to date‐correct lek counts and derive estimates of male abundance, although such an approach will likely require the incorporation of information on age structure to produce robust results that are useful for population monitoring.
Multifunctional Block Copolymers for Simultaneous Solubilization of Poorly Water‐Soluble Cholesterol and Hydroxyapatite Crystals
Authors: Keckeis Philipp , Drabinová Eliška , Ruiz‐Agudo Cristina , Avaro Jonathan , Glatt Lisa , Sedlák Miloš , Cölfen Helmut 
Published: February 2019

AbstractThe solubilization of targeted compounds represents key criteria in the sophisticated field of medical chemistry but also in technical applications like scale removal. Especially, the simultaneous dissolution of two chemically different compounds remains challenging. Herein, macromolecular solubilizers are introduced for the simultaneous dissolution and encapsulation of poorly water‐soluble cholesterol and hydroxyapatite. The peptide‐based, amphiphilic block copolymers possess physicochemically disparate segments combined in one polymer chain as binding sites for hydrophobic as well as ionic materials. Small polymer libraries are synthesized and screened for structure–property relationships. Complementary analytical techniques suggest polymeric self‐assembly into spherical adaptive nanoparticles with the fundamental ability to passively absorb significant amounts of hydrophobic cholesterol up to 33 wt%. Furthermore, the additional incorporation of acidic domains enables the simultaneous dissolution of hydrophobic compounds and mineral phases such as hydroxyapatite. Ultimately, those nontoxic block copolymers can be used to solubilize and absorb other lipophilic and ionic compounds such as Sudan III dye and calcium ions. Such multifunctional nanomaterials have a wide range of direct application for simultaneous dissolution or delivery of hydrophobic molecules and cations resp. minerals for instance in the field of atherosclerosis.
Unified Catalyst for Efficient and Stable Hydrogen Production by Both the Electrolysis of Water and the Hydrolysis of Ammonia Borane
Authors: Liu Yuan , Yong Xue , Liu Zhongyi , Chen Zhimin , Kang Zhenhui , Lu Siyu 
Published: February 2019

AbstractHydrogen is a promising energy carrier for a future sustainable energy economy. The two most promising routes for its large‐scale production in high purity are electrocatalytic water splitting and chemical release from hydrogen‐storage materials. The rational design and synthesis of robust catalysts for hydrogen evolution are crucial stages in the development of hydrogen as an energy source. This work reports the production of a novel hydrogen evolution catalyst consisting of uniform hollow porous carbon spheres loaded with ruthenium nanoclusters via a simple hydrothermal process at low temperature. The catalyst not only exhibits extraordinary catalytic activity for the hydrogen evolution reaction, with extremely low overpotentials at all pH values, but also shows outstanding activity for hydrolysis of ammonia borane (AB) with a high turnover frequency. Furthermore, the catalyst remains stable during both reactions, thus allowing one unified catalyst to facilitate hydrogen generation by two different methods for highly efficient and superstable hydrogen production. This work may provide a template method for rational design and fabrication of various metals/N‐doped carbon catalysts that promote hydrogen production through both the electrolysis of water and the hydrolysis of AB, which will advance the development of hydrogen as an energy source.
Neutrophilic eccrine hidradenitis secondary to pegfilgrastim in a patient with synovial sarcoma
Authors: Puar Neha , Scheele Allek , Perez Marques Francesca , Panicker Jyoti 
Published: February 2019

Key Clinical MessageHere, we report a case of neutrophilic eccrine hidradenitis (NEH) in a teenage male with synovial sarcoma associated with extracutaneous manifestations including myositis and splenomegaly secondary to pegfilgrastim. To the best of our knowledge, NEH has not been previously reported to occur in association with extracutaneous manifestations.
Mitochondrial complex deficiency by novel compound heterozygous TMEM70 variants and correlation with developmental delay, undescended testicle, and left ventricular noncompaction in a Japanese patient: A case report
Authors: Hirono Keiichi , Ichida Fukiko , Nishio Natsuhito , Ogawa‐Tominaga Minako , Fushimi Takuya , Feichtinger Rene′ G. , Mayr Johannes A. , Kohda Masakazu , Kishita Yoshihito , Okazaki Yasushi , Ohtake Akira , Murayama Kei 
Published: February 2019

Key Clinical MessageWe identified novel compound heterozygous TMEM70 variants in a Japanese patient who had hyperlactacidemia, metabolic acidosis, hyperalaninemia, developmental delay, undescended testicle, and left ventricular noncompaction. The urinary organic acids profile revealed elevated levels of 3‐MGA, and BN‐PAGE/Western blotting analysis and ETC. activity confirmed complex V deficiency.
Interpretation of the Role of Composition on the Inclusion Efficiency of Monovalent Cations into Cobalt Hexacyanoferrate
Authors: Zhang Nan , Kawamoto Tohru , Jiang Yong , Takahashi Akira , Ishizaki Manabu , Asai Miyuki , Kurihara Masato , Zhang Zhenya , Lei Zhongfang , Parajuli Durga 
Published: February 2019

AbstractCobalt hexacyanoferrate of various compositions was prepared in flow mode and the role of the vacancy on the structure, thermogravimetric (TG) properties, and the adsorption efficiency was studied. The material, NayCo[Fe(CN)6]1−x⋅z H2O, with a minimum vacancy of x=0.014 to the highest x=0.47, was obtained. The TG‐differential scanning calorimetry (DSC) profile showed a distinct influence of the vacancy on the water release temperature. Materials with x>0.35 showed a smooth release of water at a relatively lower temperature. However, for the materials with x<0.35, water release took place in multiple steps, suggesting the existence of various forms of water. The FTIR profiles supported the existence of free and bonded water molecules. However, the materials with multiple water peaks in the FTIR spectra showed a shift of the major XRD peaks when heated at 285 °C in N2 atmosphere. Regarding the effect of the vacancy on the adsorption behavior, for NH4, the adsorption was found to be proportional to the number of Na atoms in the material, confirming the ion‐exchange process. On the contrary, the materials with low vacancy and high Na content showed nominal Cs adsorption capacity. Interestingly, the K adsorption capacity was found to be in between that of the other two ions. This means the ionic size decides the rate of placement into the interstitial sites. For larger ions like Cs, the ease of percolation via the vacancy decides the overall adsorption efficiency.
Characterization of Residence Time Distribution in a Plug Flow Reactor
Authors: Bogatykh Innokentij , Osterland Thomas 
Published: February 2019

AbstractOne of the biggest advantages of plug flow reactors lies in their narrow residence time distribution. The pulse experiment, as a common method on acquiring that distribution, relies on the tracer injection being a perfect pulse. A deviation from a perfect pulse leads to erroneous results if not taken into account. With a numerical analysis of experimental data, this effect is quantified in turbulent and laminar flow regime and the results are compared to an analytical method. Significant deviations occur mostly in the turbulent regime, which has the greatest technical relevance.
Energy conserving texture‐based adaptable compressive sensing scheme for WVSN
Authors: Subbu Lakshmi T.C. , Gnanadurai D. , Muthulakshmi I. 
Published: February 2019

SummaryWireless Sensor Networks (WSN) have gained considerable research interest due to its wider applicability and efficiency. Due to the technological advancement, the WSN is multifaceted and one of the facets is the Wireless Visual Sensor Network (WVSN). The core functionality of WVSN is to handle multimedia data that involves data processing and transference, which, in turn, consumes more energy. Data transference requires more energy and the energy consumption is reduced by the concept of compressive sensing. Understanding the benefits of compressive sensing, this article proposes an adaptable compressive scheme that relies on the texture property of the video frames. The texture property is extracted by means of Local Directional Pattern (LDP). The performance of the proposed approach is evaluated in terms of image quality, time, and energy consumption. The proposed approach outperforms the comparative approaches with reasonable performance.
Early (Day 15 Post Diagnosis) Peripheral Blood Assessment of Measurable Residual Disease in Flow Cytometry is a Strong Predictor of Outcome in Childhood B‐Lineage Lymphoblastic Leukemia
Authors: Loosveld Marie , Nivaggioni Vanessa , Arnoux Isabelle , Bernot Denis , Michel Gérard , Béné Marie C. , Eveillard Marion 
Published: February 2019

BackgroundIn children with acute lymphoblastic leukemia (ALL) low levels of minimal residual disease (MRD) after induction, essentially assessed in the bone marrow, have been shown to be of good prognosis. However, only few studies have tested the peripheral blood for MRD.MethodsHere, we report the impact on survival of peripheral blood (PB) MRD assessment by multiparameter flow cytometry (MFC) at early time points of treatment in 125 B‐ALL children, compared to Day 35 molecular bone marrow (BM) MRD. Patients were sampled for MFC one week postdiagnosis after a pre‐phase of corticotherapy (Day 8), then after one week of chemotherapy (Day 15). The study enrolled 67 boys and 58 girls with a median follow‐up of 52 months. Over the duration of the study, 20 patients relapsed and eight died. MFC was performed based on the leukemia‐associated immunophenotype at diagnosis, using panels of 10 antibodies.ResultsAlthough, PB MFC‐MRD had no prognostic impact at Day 8, Day 15 MRD negativity was associated with a significantly better 4 years DFS (91.6 ± 3% vs. 67.6 ± 9% P = 0.0013). Furthermore, while MFC and molecular data were concordant in most cases, patients with detectable PB MRD on Day 15, yet negative in BM on Day 35 had a significantly lower DFS (P < 0.0001).ConclusionThis study demonstrates that the less invasive procedure of MFC‐MRD assessment in PB can be informative for childhood ALL patients at the early point of Day 15 of the treatment schedule. © 2019 International Clinical Cytometry Society
Textile Bewehrung in der Lagerfuge von Kellermauerwerk und windbelasteten Ausfachungswänden
Authors: Erler Maik , Jäger Wolfram 
Published: February 2019

AbstractThe successful structural verification of basement walls under earth pressure loading with light vertical loading is often difficult. This situation is often encountered for external basement walls under terrace doors, stairs, masonry light wells, etc., where the vertical loading that is theoretically necessary is absent. This makes it impossible to resist the acting flexural forces from earth using a vertical arch model alone. In such cases the basement wall must also resist the earth pressure in a horizontal direction. However, due to the fact the bending moment capacity of unreinforced masonry parallel to the bed joint is low you have the option here of using a textile‐reinforced bed joint with longitudinal fibres of alkali‐resistant glass or carbon fibre. With an appropriately adapted textile reinforcement in the bed joints, the masonry can fulfil the requirements for load‐bearing capacity against earth pressure with a horizontal load transfer, even under a small vertical load. The same applies to infill walls subjected to high wind loads the bending moment capacities of which are also slightly parallel to and vertically to the bed joint and cannot be provably demonstrated on large infill surfaces and strong wind loads. The load‐bearing can also be increased by improving the flexural strength parallel to the bed joint. The Chair of Structural Design in the Faculty of Architecture of the Technical University (TU) Dresden was carrying out extensive numerical and experimental studies for this purpose. In the journal Mauerwerk 01/2018 [1] first findings from small trial series have already been presented. In the meantime, a series of large‐scale tests have additionally been performed to check the promising results of the small‐scale tests with respect to their real applicability. This report should provide a combined insight into the work of the concluded research project.