bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of a self-help intervention to build social confidence in people living with visible skin conditions or scars: a think-aloud study
Authors: Pasterfield Madeline , Clarke Sally-Anne , Thompson Andrew R 
Published: January 2019

Introduction: People with a visible difference, such as scarring or a skin condition, can experience anxiety and intrusive reactions from others when in social situations. The use of products to conceal marks on the skin is provided in a number of different hospital services and by charities. However, there are relatively few psychosocial interventions available for these individuals. Objectives: To examine the views of skin camouflage users and practitioners on the acceptability, usability and need for a specifically developed cognitive behavioural therapy (CBT) self-help booklet. Methods: A think-aloud protocol and descriptive form of thematic analysis were used to ascertain participants’ views of this novel psychosocial intervention. Nine participants took part in think-aloud interviews that were analysed using thematic analysis. Six skin camouflage users and three skin camouflage practitioners participated in the study. Results: Support for the relevance, acceptability and usability of the booklet was found from both participants who used camouflage and those who provided it. However, some participants reported that they would envisage that some people would need additional support so as to be able to use the techniques described within the booklet. Conclusions: This study represents an important step towards developing a brief self-help intervention for people with living with visible skin conditions or scars and demonstrates the importance of seeking feedback from experts by experience on theoretically informed psychological interventions for this patient group.
Matching precision of the reverse contralateral radial head in generating of the individualized prosthesis from the surface registration in tuberosity-neck and in tuberosity-diaphysis
Authors: Luenam Suriya , Vongvanichvathana Adigun , Kosiyatrakul Arkaphat , Kongphanich Chutcharn , Chanpoo Malee , Koonchornboon Tunyarut , Phakdeewisetkul Kantapat , Lohwongwatana Boonrat , Puncreobutr Chedtha 
Published: January 2019

Purpose: Following the radial head replacement, the surface mismatches between the implants and the morphological characteristics of the original proximal radius decreased contact areas and increased contact forces which is potential for the long-term articulating cartilage wear. Several studies demonstrated that the individualized prosthesis, created from computed tomographic (CT) images of the contralateral side with the reverse engineering technology, may reduce the mismatch. The aim of this study is to demonstrate the matching precision of the reverse contralateral head between the surface registration in tuberosity-neck (TN) area and in tuberosity-diaphysis (TD) area. Materials and Methods: High-resolution CT scan of 11 pairs of the cadaveric arms was performed. Utilizing advanced image processing techniques, three-dimensional (3-D) models of each specimen was generated. The model of the left side was reversed and matched with the model of the right side in the same cadaver by registering in the area of radial neck along with tuberosity (TN) and in the area of radial tuberosity combined with 2 cm of proximal diaphysis (TD). The alteration of the head diameter, dish diameter, articular depth, head thickness, end-plane angle, offset, and head volume were evaluated and analyzed by paired t-test. Results: No statistically significant difference was found in all parameters from both TN and TD registrations ( p < 0.05). Conclusion: The surface registration in either TN or TD area can generate the statistically symmetrical 3-D model with the original head. The registration in these areas may possibly be used in creating the individualized radial head prosthesis.
JectOS® versus PMMA vancomycin-loaded cement: The biomechanical and antimicrobial properties
Authors: Singh Vivek Ajit , Wei Chang Chee , Haseeb Amber , Shanmugam Rukmanikanthan , Ju Cindy Shuan 
Published: January 2019

Purpose: Bone cement is commonly used as a void filler for bone defects. Antibiotics can be added to bone cement to increase local drug delivery in eradicating infection. After antibiotic elution, nonbiodegradable material becomes an undesirable agent. The purpose of this study was to evaluate effects of addition of vancomycin on the compressive strength of injectable synthetic bone substitute, JectOS®. JectOS, a partially biodegradable cement that over time dissolves and is replaced by bone, could be potentially used as a biodegradable antibiotic carrier. Methods: Vancomycin at various concentrations was added to JectOS and polymethyl methacrylate (PMMA). Then, the cement was molded into standardized dimensions for in vitro testing. Cylindrical vancomycin–JectOS samples were subjected to compressive strength. The results obtained were compared to PMMA-vancomycin compressive strength data attained from historical controls. The zone of inhibition was carried out using vancomycin-JectOS and vancomycin-PMMA disk on methicillin-resistant strain culture agar. Results: With the addition of 2.5%, 5%, and 10% vancomycin, the average compressive strengths reduced to 8.01 ± 0.95 MPa (24.6%), 7.52 ± 0.71 MPa (29.2%), and 7.23 ± 1.34 MPa (31.9%). Addition of vancomycin significantly weakened biomechanical properties of JectOS, but there was no significant difference in the compressive strength at increasing concentrations. The average diameters of zone of inhibition for JectOS-vancomycin were 24.7 ± 1.44 (2.5%) mm, 25.9 ± 0.85 mm (5%), and 26.8 ± 1.81 mm (10%), which outperformed PMMA. Conclusion: JectOS has poor mechanical performance but superior elution property. JectOS-vancomycin cement is suitable as a void filler delivering high local concentration of vancomycin. We recommended using it for contained bone defects that do not require mechanical strength.
EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma
Authors: Sivarajah Shanmugappiriya , Kostiuk Morris , Lindsay Cameron , Puttagunta Lakshmi , O'Connell Daniel A. , Harris Jeffrey , Seikaly Hadi , Biron Vincent L. 
Published: January 2019

Background This study aims to investigate EGFR as a prognostic biomarker in oropharyngeal squamous cell carcinoma (OPSCC). Methods OPSCC patients from retrospective (1998–2009) and prospective cohorts (2014–2017) were included. Retrospectively collected tumors were used to construct tissue microarrays (TMAs), which were stained with EGFR, p16, DAPI and Pan-cytokeratin, and digitally quantified. EGFR, CDKN2A and HPV E6/7 levels from prospectively collected OPSCC was measured by droplet digital PCR (ddPCR). Biomarkers were compared to patient covariates, factors and survival outcomes. Results A total of 249 patients were included retrospectively and 64 patients were enrolled prospectively. p16 status ( p < 0.001), smoking above 10 pack years ( p = 0.04), smoking above 20 pack years ( p < 0.001), total EGFR tumor levels ( p = 0.016), and high EGFR within high or low Ki67 tumor nuclear staining ( p = 0.03) were found to be significant predictors of 5-year disease specific survival (DSS). A Cox proportional hazard model of DSS showed smoking status and eGFR expression to be dependent of each other on predicting 5-year DSS. ddPCR analysis showed a significant association between smoking status and EGFR levels. Conclusions Total EGFR tumor levels are predictive of 5-year DSS. EGFR levels correlate with. smoking and could be an objective marker for this disease etiology.
Anxiety scales used in pregnancy: systematic review
Authors: Sinesi Andrea , Maxwell Margaret , O'Carroll Ronan , Cheyne Helen 
Published: January 2019

BackgroundAnxiety disorders and self-reported symptoms are highly prevalent in pregnancy. Despite their negative impact on maternal and child outcomes, uncertainty remains regarding which symptoms can be considered accurate indicators of antenatal anxiety.AimsTo examine and synthesise the evidence in relation to the psychometric properties and content of self-report scales used to detect anxiety symptoms in pregnant women.MethodA systematic search was carried out and the methodological quality of all included studies was assessed. Only those achieving a rating of good or excellent were considered in a synthesis of the best available evidence.ResultsSeveral anxiety symptoms and domains were identified as promising for screening for general antenatal anxiety and pregnancy-related anxiety, including elevated levels of worry, symptoms of panic, fear of childbirth and excessive worries about the baby's health.ConclusionsThis review contributes to the existing knowledge by identifying a number of anxiety symptoms that can be considered psychometrically robust indicators of antenatal anxiety.Declaration of interestNone.
Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation
Authors: Lo Pang-Kuo , Huang Yi-Chun , Corcoran David , Jiao Renjie , Deng Wu-Min 
Published: January 2019

ABSTRACT
Chromatin assembly factor 1 (CAF1), a histone chaperone that mediates the deposition of histone H3/H4 onto newly synthesized DNA, is involved in Notch signaling activation during Drosophila wing imaginal disc development. Here, we report another side of CAF1, wherein the subunits CAF1-p105 and CAF1-p180 (also known as CAF1-105 and CAF1-180, respectively) inhibit expression of Notch target genes and show this is required for proliferation of Drosophila ovarian follicle cells. Loss-of-function of either CAF1-p105 or CAF1-p180 caused premature activation of Notch signaling reporters and early expression of the Notch target Hindsight (Hnt, also known as Pebbled), leading to Cut downregulation and inhibition of follicle cell mitosis. Our studies further show Notch is functionally responsible for these phenotypes observed in both the CAF1-p105- and CAF1-p180-deficient follicle cells. Moreover, we reveal that CAF1-p105- and CAF1-p180-dependent Cut expression is essential for inhibiting Hnt expression in follicle cells during their mitotic stage. These findings together indicate a novel negative-feedback regulatory loop between Cut and Hnt underlying CAF1-p105 and CAF-p180 regulation, which is crucial for follicle cell differentiation. In conclusion, our studies suggest CAF1 plays a dual role to sustain cell proliferation by positively or negatively regulating Drosophila Notch signaling in a tissue-context-dependent manner.
A Coevolution Model of Network Structure and User Behavior: The Case of Content Generation in Online Social Networks
Authors: Bhattacharya Prasanta , Phan Tuan Q. , Bai Xue , Airoldi Edoardo M. 
Published: January 2019

With the rapid growth of online social network sites (SNSs), it has become imperative for platform owners and online marketers to quantify what factors drive content production on these platforms. Previous research identified challenges in modeling these factors statistically using observational data, where the key difficulty is the inability of conventional methods to disentangle the effects of network formation and network influence on content generation from the subsequent feedback effect of newly generated content on network structure. In this paper, we adopt and enhance an actor-oriented continuous-time statistical model that enables the joint estimation of the coevolution of the users’ social network structure and of the amount of content they produce, using a Markov chain Monte Carlo–based simulation approach. Specifically, we offer a method to analyze nonstationary and continuous-time behavioral data, typically recorded in social media ecosystems, in the presence of network effects and other observable and unobservable user-specific covariates. The proposed method can help disentangle network effects of interest from feedback effects on the network. We apply our model to social network and public posting data over six months to find that (1) users tend to connect with others that have similar posting behavior; (2) however, after doing so, these users tend to diverge in their posting behavior, and (3) peer influence effects are sensitive to the strength of the posting behavior. More broadly, the proposed method provides researchers and practitioners with a statistically rigorous approach to analyze network effects in observational data. Our results lead to insights and recommendations for SNS platform owners on how to sustain an active and viable community.The online appendix is available at https://doi.org/10.1287/isre.2018.0790 .
A REVIEW OF SUSTAINABILITY OF URBAN DRAINAGE SYSTEM: TRAITS AND CONSEQUENCES / REVISÃO DA SUSTENTABILIDADE DE UM SISTEMA DE DRENAGEM URBANA: CARACTERÍSTICAS E CONSEQÜÊNCIAS
Authors: Dibaba Wakjira Takala 
Published: January 2019

The negative effect of domestic effluents on the quantity and quality of water and urban amenities makes increasingly imperative to establish sustainable drainage systems in cities. Therefore, for a better plan and sustainable development of a town, it is highly imperative for environmentalists, hydrologists, land use planners and for storm and wastewater management to analyze the existing drainage system and predict the environmental responses to the discharges of urban drainage system. This study has analyzed the existing drainage system of Jimma city (Ethiopia) and identified the major factors contributing to the poor drainage performance. Jimma population growth has been increasing the problems caused by the uncontrolled release of domestic effluents and urban solid waste, with increasingly damaging consequences for the environmental quality, social wellness and economy of the city. With the intensification of Jimma development, surface water discharges from developed areas and uncontrolled wastes are being increasingly released, affecting social, environmental and economic state of the city. Lack of proper functioning drainage infrastructure, uncontrolled waste disposal, lack of periodic inspection and maintenance, poor connection of drainage networks and roads and carelessness led to the failure of the existing drainage system. These conditions caused drainage blockages, resulting in overflows and floods, leading to less and less attractive conditions in the city and making some places unfit to be inhabited. ResumoO efeito negativo dos efluentes domésticos sobre a quantidade e a qualidade da água e o bem estar urbano torna cada vez mais imperioso o estabelecimento de sistemas sustentáveis de drenagem. Por isso, a análise do sistema de drenagem existente e a previsão das respostas ambientais às descargas urbanas são altamente imperativas tendo em vista um melhor planejamento e desenvolvimento sustentável de uma cidade. Este estudo analisou o sistema de drenagem da cidade de Jimma (Etiópia) e identificou os principais fatores que contribuem para o seu mau funcionamento. O crescimento populacional de Jimma tem vindo a ampliar os problemas causados pela libertação descontrolada de efluentes domésticos e resíduos sólidos urbanos, com consequências cada vez mais nefastas para a qualidade ambiental, para o bem estar social e a economia da cidade. O funcionamento inadequado da infraestrutura de drenagem, o descarte descontrolado de resíduos sólidos urbanos e a falta de inspeção e manutenção periódicas, a conexão deficiente de redes de drenagem e estradas e o descuido conduziram á inoperância do sistema de drenagem existente. Estas condições causaram bloqueios de drenagem, resultando em transbordamentos e inundações, tornando a cidade cada vez menos atrativa e tornando alguns locais impróprios para ser habitados.
AMMONIA-ELPHIDIUM INDEX AS A PROXY FOR MARINE POLLUTION ASSESSMENT, NORTHEAST BRAZIL / O uso do índice Ammonia-Elphidium como proxy para a avaliação da poluição marinha do nordeste brasileiro
Authors: Pregnolato Leonardo Antonio , Viana Rayssa De Almeida , Passos Camila Cunha , Misailidis Maria Laura , Duleba Wânia 
Published: January 2019

The Ammonia-Elphidium Index (IAE) allows to assess the oxygenation levels of coastal regions. Both genera used in this index are resistant to oxygen reduction conditions. The genus Ammonia has a greater resistance than the genus Elphidium to low oxic conditions, and both are abundant in the coastal zones, which makes possible the use of this index to access the impact caused by organic matter pollution in these regions. Hence, this index has been used in the literature to study polluted regions by large contribution of organic carbon. The Petrobras Polo Atalaia Production complex is responsible for the outfall of treated petrochemical effluents, called PAP-1, which introduce pollutants in the coastal area of Sergipe State, northeast Brazil. In view of the environmental complexity of the region, the objectives of this work were: 1) to analyze the dimension and diversity of living foraminifera assemblages in surface sediment samples collected in February 2014 around the Sergipe-Mar Subsea Outfall of Active Production (SMP); and 2) to apply the Ammonia-Elphidium index in this region as a proxy of environmental impact. The results allowed to evaluate the impact caused by the contribution of the effluents released by the SMP outfall of the Petrobras Polo Atalaia Production complex and their influence on the density and diversity of living benthic foraminifera in the study area. ResumoO índice de Ammonia-Elphidium (IAE) permite avaliar os níveis de oxigenação das regiões costeiras. Ambos os gêneros são resistentes às condições de redução de oxigênio. O gênero Ammonia apresenta uma resistência maior que o gênero Elphidium à escasses de oxigénio, sendo ambos abundantes em zonas costeiras, o que possibilita a utilização deste indice na avaliação do impacto causado pela poluição por matéria orgânica nessas regiões. O complexo denominado Polo Atalaia, da Petrobras, é responsável pelo emissário de efluentes petroquímicos tratados, denominado PAP-1, o qual é responsável pela introdução de poluentes na zona costeira do Estado do Sergipe, no nordeste brasileiro. Diante da complexidade ambiental da região, os objetivos deste trabalho foram: 1) analisar os foraminíferos da região situada ao redor do emissário submarino do ativo de Produção Sergipe-Mar (PSM), coletados em fevereiro de 2014; e 2) calcular o índice Ammonia-Elphidium. Os resultados permitiram avaliar o impacto causado pelo aporte de efluentes e sua influência na densidade e diversidade de foraminíferos bentônicos na área estudada.
Trueness Evaluation and Verification of Interassay Agreement of 11 Serum IgA Measuring Systems: Implications for Medical Decisions
Authors: Braga Federica , Infusino Ilenia , Frusciante Erika , Ceriotti Ferruccio , Panteghini Mauro 
Published: January 2019

AbstractBACKGROUNDTo identify an IgA deficiency, the availability of reliable IgA lower reference limits is essential, especially in pediatrics. In this study, we reported the results of an intercomparison study aimed to verify the status of standardization of IgA measurements using 11 commercially available measuring systems (MSs).METHODSAfter confirming its commutability, the ERM-DA470k/IFCC reference material was used for the trueness evaluation of IgA MSs. Furthermore, the interassay agreement was verified using 18 patient pools. By combining the bias, if any, between the obtained mean of ERM-DA470k/IFCC and its target value and the mean imprecision of MSs with the uncertainty of respective calibrators, we also estimated the mean uncertainty (U) of IgA measurements on clinical samples.RESULTSAlthough the majority of IgA MSs were sufficiently aligned with each other, the bias against the ERM-DA470k/IFCC target value was unacceptable in 55% of cases. This bias resulted in an excessive U of IgA measurement on clinical samples. Importantly, when the analysis focused on the lower IgA concentrations—typical of children—the situation worsened, with only 4 MSs showing good equivalence.CONCLUSIONSAlthough the harmonization among most commercially available IgA MSs is good, the implementation of traceability to higher order references is inadequate, especially at concentrations ≤0.7 g/L. This analytical background information needs to be considered carefully when defining traceable reference intervals in the pediatric population.
A key to the genera and subgenera of stingless bees in Indonesia (Hymenoptera: Apidae)
Authors: Engel Michael S. , Kahono Sih , Peggie Djunijanti 
Published: January 2019

Indonesia harbors the greatest diversity of social bees in all of Asia, particularly of the stingless bees (Apidae: Apinae: Meliponini). Presently, 46 species of stingless bees are known across Indonesia although records are not comprehensive and additional diversity is likely present across the region. All of the known Asiatic genera of Meliponini occur in Indonesia, making this region a critical center of modern stingless bee biodiversity in Asia. Presented here is an illustrated key to the genera and subgenera of Indonesian stingless bees, as an aid to the general identification, study, and conservation of these critical pollinators.
Early Excision And Skin Allograft Helps To Control Infection In Major Burn At Burn Unit Cipto Mangunkusumo Hospital
Authors: Natasha Ratna Rayeni , Wardhana Aditya 
Published: January 2019

Backgrounds: Burns are systemic complex injuries following an exposure to thermal energy and can cause damage to the skin. Skin, as body cover, will protect the underlying tissue from infection, act as a thermo regulator and control the evaporations. The principle of burn therapy is to remove the necrotic tissue and to replace the function of the skin in the body by using a temporary cover with synthetic dressings or skin allograft. Skin allograft remains an ideal temporary cover, particularly when sufficient autograft skin is not available.Patients and Methods: We performed early excision and cover the wound with cadaver skin allograft in two patients suffered from major burn admitted to Cipto Mangunkusumo Hospital in 2012. We observed the wound clinically and monitored the leukocytes count to evaluate the rate of infection.Results: We observed four patients with major burn. Two patients treated with early excision and skin allograft has decreasing in exudates production, less bad odor in wound area, body temperature stable in normal value and also the decreasing leukocytes counts gradually. The results of wound area and body temperature in two patients treated conventionally are not much different from the initial wound and have high leukocytes count more than 10.000 in the majority of laboratory findings. The skin allograft can control the infection by suppressing the bacterial proliferation, promote epithelialization and prepare the wound better.Summary: Patient in this study treated with early excision and skin allograft has better outcome compared to patients treated conservatively.