bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFIL PENDERITA KANKER PAYUDARA STADIUM LANJUT BAIK LOKAL MAUPUN METASTASIS JAUH DI RSUP HASAN SADIKIN BANDUNG
Authors: Sander Mochamad Aleq 
Published: January 2019

Breast cancer represent one of the most second malignancy of the woman after cervix cancer. In Indonesia estimated ±100 new case per 100.000 population every year, meaning more or less 200.000 new case every year to all cancer type. While for the breast cancer ± 23.140 new case every year. If breast cancer found in early stage, it has high life expectancy, ranging from 85-95%. But actually 70-90% patient came to hospital after their disease were hard and advanced stage. Cancer medication at advanced stage was very difficult and its result very dissatisfactory. The aim of research is to know the epidemiology, clinical symptom, diagnosis, therapy, prognosis. Descriptive study with retrospective design. Total sampling was all outpatient in oncology deparment of Hasan Sadikin Hospital of Bandung with advanced stadium of breast cancer from January 2003 up to December 2008. 164 eligible respondens who had age below 35 yo 28 (17.1%) and above 35 yo 136 (82.9%). Average of menarche 11.77 yo. Location of right breast cancer 78 (47.6%), left 82 (50%), and both 4 (2.4%). A lot of stadium was T4bNoMx that is 18 (11%). Chest x-ray, laboratory, and USG were the most diagnostic procedure often used that is 19 (11.6%). The most common therapy was BE+VC+RM that is 17 (10.4%). The prognosis was healing 20 (12.2%), not/not yet healed 30 (18.3%), not control 110 (67.1%), and who control in the other place 4 (2.4%). Conclusion was mostly diagnosis of breast cancer according to anatomy pathology, chest x-ray, laboratory, and ultrasonografi. A lot of breast cancer location was left side. Excision biopsy, and followed by radical mastectomy were the most therapy procedure. Therapy evaluation to assess the level of healing was difficult because most patient did not conduct the control after therapy.
PENGARUH IKLAN OBAT FLU DI TELEVISI TERHADAP PEMILIHAN OBAT SECARA SWAMEDIKASI PADA MASYARAKAT DI MALANG
Authors: Rachmawati Hidajah 
Published: January 2019

Communications is process transfer of information signing the forwarding of message of someone to others, either through indirect and also direct that is media.Television as a mass media technically capable of informing public in numerous amount in the same time. One of television program offering various product to fulfill requirement and satisfaction of physical is commercial. Such commercial is influenza drug commercial, because met many people. This matter of tendency make people to do self-medication as solving of from problem of health which they recognize by self. Data collecting uses purposive sampling method in 102 respondents . Instrument test is done by validity test and reliability testing . Data analysis tool used is correlation analysis,t-test and regression analysis. Based on the result of the research, correlation coefficient is 0.645 so r table is 0,195, means there is a relation between influenza drug commercial and self-medication drug of choice. Based on the test t, t calculation is 2,376 so t table is 1,980, means there is influenza drug commercial in television has significant effect to self-medication drug of choice with equation regression Y = 4.803 + 0.522 x, means if influenza drug commercial in television indicator increasing 1 so self-medication drug of choice increasing 0.522. Value Sig. Of 0.000 <0.05 then the correlation coefficient deduced influenza drug commercial to self medication ‘s drug of choice in people in Malang is significant.
Evaluasi Efektivitas dan Keamanan Penggunaan Obat Anestesi Umum di RS PKU Muhammadiyah Yogyakarta
Authors: Inayati Istiqoma Dewi Kurniawati Zullies Ikawati 
Published: January 2019

Anesthesia is given to more than 75 million surgical patients annually, wordwide. An ideal anesthetic drug would induce anesthesia smoothly and rapidly while allowing for prompt recovery after its administration is discontinued. The drug would also prossess a wide margin of safety and be devoid of adverse effects. The objective of the study was to get an overview on use of general anesthesia at PKU Muhammadiyah hospital, Yogyakarta which included aspects of dose induction relevance, effectiveness of general anesthesia based on onset dan duration recovery and safety based on cardiovascular and respiratory side effects which happened due to induction anesthesia.The study used descriptive case series design carried out prospectively. Data were obtained from observation of elective surgery patient in Instalasi Bedah Sentral at PKU Muhammadiyah hospital, Yogyakarta. Sample were collected by concecutive sampling methods on Maret-Juni 2010. Onset, duration recovery were monitored after induction anesthesia. Systolic and diastolic blood pressure, heart rate, saturation were monitored 0 minute before induction and 5 minute after induction anesthesia.From 84 patient, as many as 72,62% were relevant dose with induction and 27,38% were irrelevant dose. Effectivity anesthesia based on onset was 100% effective Recovery from isoflurane was 4-11 minute faster than with sevoflurane and 1-4 minute faster than hallotane. Cardiovascular side effect was not significant between relevant and irrelevant dose Induction. No respiratory side effect was found.
Efek Ateroprotektif dan Vasoprotektif Katekin Teh Hijau terhadap Ekspresi eNOS pada Tikus Wistar Jantan dengan Diet Tinggi Lemak
Authors: Retty Ratnawati Erna Susanti 
Published: January 2019

Catechins , isolate from green tea GMB4 clones could be developed as a potential preventive agent for atherosclerosis. This activity is thought to be based on the structure epimerisation, hydroxy phenolic and galloil group of these isolates. The purpose of this study is to prove the influence catechins ,isolate from green tea, on the inhibition of the decrease eNOS expression in male wistar rats induced by high fat diet. The method used in this study consisted of ELISA for measurement of eNOS expression. The results showed that catechins inhibits the decreasing expression of eNOS at a dose of 6 mg / day and 24 mg / day was significantly but not dose 3mg / day. This suggests a dose 6mg / day and 24 mg / day is able to repair the damage signaling insulin on PI3K pathway caused by insulin resistance. These results are based on the ability of catechins as antioxidants. Catechins with hydroxy phenolic group is a potential electron donor to bind free radicals. Polyphenol catechins may also modulate signaling cellular processes such as NFkâ, activator protein 1 DNA binding, glutathione biosynthesis, PI3K / Akt, MAPK pathway and the Nrf2 transcription factor that regulates expression of several antioxidant genes. It can be concluded catechins inhibits decreasing expression of eNOS at a dose of 6 mg / day and 24 mg / day and can be developed as an agent and vasoprotective ateroprotective.
PROFIL KEPATUHAN PENGGUNAAN OBAT HIPOGLIKEMIK ORAL GLIBENKLAMID (Pada Pasien Diabetes Mellitus Tipe 2 di Puskesmas Kedungkandang Malang)
Authors: Hidajah R Masita Rinaldia 
Published: January 2019

Indonesia is one of the developing countries and listed as number seven rank in the world as a country with problems with the disease. Increasing prosperity in developing countries and changes in lifestyle lead to increased prevalence of degenerative diseases one of them with diabetes mellitus (DM). Patients with diabetes mellitus need support from other families also need support from professionals in the health sector such as doctors, nurses, pharmacy. With the support - support that is given so that it can improve the quality of life of people and with diabetes mellitus. This study aimed to profile the compliance in the use of oral hypoglycemic glibenclamide. This research was conducted using descriptive research design. Samples were taken from patients with type 2 diabetes mellitus patients in health centers Kedungkandang Malang. Research done by giving questionnaires and visits from the remaining drug count glubenklamid obtained. From the description of the questions is obtained for 73.3% never received an explanation from the pharmacist and 70% of patients did not request an explanation from the pharmacist. Amounted to 86.7% of patients knew the use of drug glibenclamide. 56.7% of patients returned to the clinic every drug out and amounted to 50% of patients received support from family. Patients using the drug each day with a percentage of 53.3% and 66.7% of information on how to read and drink a patient using the drug in accordance with the percentage dose of 70% and use drug the morning before eating with a percentage of 46.7% and 63.33% and patients who never experienced drug side effects of 76.7%. From the calculation of drug remaining is calculated from the sum of all the samples showed results of 83.3% compliance. So the usage of drug compliance glibenclamide in patients with type 2 Diabetes in Primary Health Care Melllitus Kedungkandang Malang by 83.3%.
Pengembangan Matrik Lepas Lambat Berbasis EC – PVP K30 Menggunakan Teknik Dispersi Solida Dengan Model Obat Natrium Diklofenak
Authors: Arina Swastika Maulita Yulistia Budianti Soemarie 
Published: January 2019

This research is a modification of controlled release which beneficially to optimize the medicine reaction and to minimize the fluctuation of blood level in a certain period of the release. The aim of research is to develop the matrix system in ethylcellulose basic PVP K30 which applies dispersion solid method using sodium diclofenac as sample. Resulted four formulas consist of PVP K30 percentages as follow 0%, 5%, 10% and 20%. The different percentages of PVP K30 is aimed to know the formula which produces the releasing result of ND more optimal. This research produces in each formula significant differences (p<0,05). The formula whole percentages of PVP K30 10% has completed the requirements of control release better than the other one, shown the better resistance characteristics and release profile.
METABOLIC PSEUDOPROGRESSION AS NEW PHENOMENON ON [11C]METHIONINE PET/CT DURING TREATMENT MONITORING OF PATIENTS WITH MALIGNANT CEREBRAL GLIOMA
Authors: Skvortsova T. Yu. , Savintseva Zh. I. , Gurchin A. F. , Trofimova T. N. 
Published: January 2019

With improved treatment for cerebral gliomas leading to longer survival, late rare complications of radiation therapy on the brain are more frequently observed. The paper presents the results of positron emission tomography (PET) with [11C]methionine in 4 patients with malignant cerebral glioma, in whom the phenomenon of transient diffuse high [11C]methionine uptake in the cerebral cortex was detected during treatment monitoring. The unilateral high [11C]methionine uptake in the posterior portion of the cerebral hemisphere was stereotyped and easy to recognize. Nevertheless high amino acid uptake on PET did not match with structural abnormalities on MRI and was not accompanied by aggravation of neurological symptoms or by epileptic seizures. The results of the follow-up examinations excluded tumor recurrence. The control PET/CT scans showed complete resolution of the abnormal [11C]methionine uptake. The clinical and instrumental similarity of the presented cases allowed to establish the diagnostic criteria for the phenomenon of metabolic pseudoprogression and to compare them with the criteria of the SMART syndrome (stroke-like migraine attacks after radiation therapy). Two cases with SMART syndrome are presented as a comparison group. The similarities and discrepancies of unusual metabolic hyperfunction with previously known phenomena and possible mechanisms for their development are discussed. It is important for clinicians and radiologists to be aware of the characteristic imaging findings of the metabolic pseudoprogression on PET with [11C] methionine to avoid overdiagnosis of the brain tumor recurrence and aggressive treatment approach.
COMPARATIVE ANALYSIS OF DUAL ENERGY X-RAY AND BIOIMPEDANCE ANALYSIS IN THE ASSESSMENT OF COMPONENT COMPOSITION OF THE BODY OF HAEMODIALYSIS PATIENTS
Authors: Jakovenko A. A. , Shestopalova O. Y. , Rumyantsev A. Sh. , Somova V. M. 
Published: January 2019

The aim of the study. Compare the efficiency of the use of dual-energy x-ray absorptiometry (DRA) and bioimpedansometry (BIM) in the evaluation of the body composition of hemodialysis patients.Patients and methods. 67 patients on hemodialysis, among which 23 men and 44 women aged 54±14,4 years. BIM and DRA were used to evaluate the body composition.Results. The results of determining the total muscle mass of the body obtained by the results of DFA and BIM were compared with the use of the Bland-Altman method. The correlation coefficient between the indices was R=0,994, p<0,0001, delta (M±s) was –0,48±0,91 kg, CI 95% (–0,71)…(–0,26) kg.Conclusion. DRA does not have significant advantages over tetrapolar multifrequency BIM when assessing the body composition in hemodialysis patients.
Los genes como marcadores de riesgo en cáncer gástrico: revisión de estudios en población colombiana
Authors: Yáñez-Gutiérrez Claudia Marcela 
Published: January 2019

El objetivo de esta revisión, fue identificar el rol de los genes como marcadores de riesgo en cáncer gástrico (CG) en población colombiana. Se revisaron publicaciones de investigaciones realizadas en los últimos diez años, utilizando las bases MEDLINE y LILACS y complementando la pesquisa con la bibliografía relevante de los artículos. Se encontraron estudios en busca de asociación de CG con polimorfismos de varios genes humanos involucrados en la respuesta inmune, la desintoxicación y el supresor p53. En Colombia al igual que en otros países, las evidencias de asociación de polimorfismos genéticos con CG son aún controversiales, debido a la variación de los resultados que arrojan los estudios en las diferentes poblaciones. El genoma de las cepas de Helicobacter pylori que infectan población colombiana también ha sido investigado en búsqueda de polimorfismos de virulencia. El genotipo cagA/vacAs1m1 identificado como citotóxico en esta bacteria, mostró en la mayoría de las investigaciones, asociación con CG. La evidencia de asociación de CG con factores genéticos en población colombiana no es concluyente. Está lejos aún, la identificación de marcadores genéticos que permitan predecir el riesgo a desarrollar CG. A pesar de ello, algunos polimorfismos de genes humanos como los de IL-1 o los de algunas enzimas desintoxicantes, así como los genes cagA y vacA de Helicobacter pylori podrían ser candidatos a futuros marcadores de riesgo en esta neoplasia.Palabras clave: cáncer gástrico, riesgo, genotipo, Colombia. ABSTRACT The objective of this review was to identify the role of genes as risk markers in gastric cancer (GC) in Colombian population studies. The study reviewed research publications in the last ten years, using the MEDLINE and LILACS, as well as various literature research of relevant articles. Searching studies found GC association with several human gene polymorphisms involved in the immune response, detoxification and suppressor p53. In Colombia, as in other countries, the evidence of the association of genetic polymorphisms with GC are still controversial because of the variation in results that studies in different populations. The genome of Helicobacter pylori strains that infect Colombian population has also been investigated in search of polymorphisms of virulence. cagA/ vacAs1m1 genotype identified as cytotoxic in this bacterium, demonstrated most of the research associated with GC. Evidence of association of GC with Colombian population genetic factors was inconclusive. It is yet to be determined the exact identification of genetic markers that can predict the risk of developing GC. However, some human gene polymorphisms as IL-1 or some detoxifying enzymes and the vacA and cagA of H. pylori could be candidates for future risk markers in these tumors.Keywords: gastric cancer, risk, genotype, Colombia
Evaluación de la motilidad espermática a través del sistema C.A.S.A de semen caprino criopreservado bajo diferentes medios diluyentes
Authors: Hernández-Corredor Leonardo , Nivia-Osuna Alexander , Hernández-Villamizar Daniel , Rubio-Parada Jorge Alexander , Quintero-Moreno Armando 
Published: January 2019

El estudio evaluó la motilidad espermática y su efecto postdescongelación en semen caprino, en dos medios comerciales (Andromed® y TwoStep®) y diferentes protocolos de congelación (medio completo, con adicción del 10% de yema de huevo, semen centrifugado y sobrenadante seminal), se utilizaron machos de la raza alpina de la Universidad Francisco de Paula Santander Ocaña, el semen fue colectado con electroeyaculador, una vez los medios terminados y parte de los contenidos seminales enteros o centrifugados mezclados, se estabilizó por 2 horas, se envasó en pajillas de 0,5 cc y se congela en vapores de nitrógeno por 10 minutos, las pajillas se llevaron al laboratorio de Andrología de la Universidad del Zulia y por medio del sistema C.A.S.A.(Computer Assisted Sperm Análisis) se evaluaron los parámetros de motilidad como velocidad curvilínea (VCL), velocidad rectilínea (VSL), velocidad lineal (VAP), índice de linealidad (LIN), índice de rectitud (STR), índice de oscilación (ALH), Amplitud media del desplazamiento lateral de la cabeza del espermatozoide (BCF), los datos fueron analizados por medio del procedimiento GLM de SAS versión 9.0; los mejores índices de motilidad (VCL, ALH, BCF) fueron expresados enel tratamiento de contenido seminal centrifugado en medio Andromed®. (p≤0,001))La mejor progresividad espermática (VSL,LIN,STR)se presentó el tratamiento de Semen completo de caprino, criopreservado en medio comercial TwoStep®. ABSTRACT The study evaluated the effect sperm motility and sperm post-thawing in goats, two commercial means (Andromed ® and Two Step ®) and different freezing protocols (complete medium with 10% addition of the egg yolk, semen centrifuged supernatant and seminal ), we used males of the Alpine race of the University Francisco de Paula Santander Ocaña, semen was collected with electroejaculator once finished media and part of the whole and centrifuged seminal contents mixed, stabilized by two hours, packed in 0.5 cc straws and frozen in nitrogen vapor for 10 min, the straws were taken to the laboratory of Andrology at the University of Zulia and through CASA system (Computer Assisted Sperm Analysis) were evaluated motility parameters such as curvilinear velocity (VCL), straight line velocity (VSL), linear velocity (VAP), linearity index (LIN), straightness index (STR) Oscillation Index (ALH ) average amplitude of the lateral displacement of the sperm head (BCF), the data were analyzed by the GLM procedure of SAS version 9.0, the highest rates of motility (VCL, ALH, BCF) were expressed in the treatment of seminal content centrifugation Andromed ® medium. (p ≤ 0.001)) The best progressive sperm (VSL, LIN, STR) will present the full Semen treatment goats, cryopreserved at Two Step ® commercial medium.Keywords: semen, buck, Andromed, Two step.
Understanding the Role of Internship as an Activity Based Learning: A Case Study
Authors: Ali Aasir , Khushi Arshad 
Published: January 2019

<p>Activity based learning is a successful educational model in various disciplines and recently it has been proved very effective in business institutes also. This paper was intended to explore the effects of internship in the university students of Pakistan as an activity based learning in order to boost their skills and abilities. Qualitative research as research design was adopted for the study following interpretivist paradigm. For the purpose of data collection, 30 students from business institutes were interviewed. Only those candidates were chosen who had recently completed their internship in well-known organizations of Pakistan. Data analyses were done through NVivo software version 11, suggested for qualitative data analyses. Findings proposed that industrial internship is a viable activity for the learning and growth of university students. Practical experience, teamwork, understanding strengths and weaknesses, financial support for further studies and exposure to real world problems were found chief outcomes of internship in terms of professional development. Likewise, goal setting, internal motivation, confidence, punctuality, regularity and understanding responsibility in terms of personality development were found as key outcomes of internship for business students. Keywords: activity based learning, business students, internships, professional development.</p>
Gender Differentials Among Teachers’ Classroom Management Strategies In Pakistani Context
Authors: Ahmed Maqsood , Ambreen Munazza , Hussain Ishtiaq 
Published: January 2019

<p>The main purpose of this study was to get an insight about teachers’ classroom<br />management strategies and explore the gender differences among teachers’ classroomstrategies. The present descriptive study was quantitative in nature andmethod was used. All the teachers, teaching in different Islamabad Model<br />Schools for Boys and Girls, Islamabad (Urban Sector) constituted the population of the. Data were collected from a sample of 126 secondary school teachers, teaching in 10 different Islamabad Model Schools for Boys and Girls, Islamabad, Pakistan. Data were collected via Classroom Management Inventory (CMI), developed by the researcher, keeping in view the Pakistani context. As a result of pilot study, reliability test of the questionnaire reflected 0.947 value of Cronbach’s Alpha, which showed the high reliability of the instrument. From the findings of the study, it was concluded that teachers’ gender affects their classroom management. Female teachers exhibited more classroom management skills on four out of six dimensions of classroom management<br />than the male teachers. Classroom management being a challenging and complex task, demand knowledge and skills on the part of teachers. It is recommended that teacher trainings should contribute to such endeavour, keeping in view the gender differentials. </p><p><strong>Keywords:</strong> gender, differentials, classroom management, strategies</p>