bluuebunny/crossref_metadata_2025_split huggingface dataset:
GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Authors: Dashti Hassan S , Jones Samuel E , Wood Andrew R , Lane Jacqueline M , van Hees Vincent T. , Wang Heming , Rhodes Jessica A , Song Yanwei , Patel Krunal , Anderson Simon G , Beaumont Robin , Bechtold David A , Bowden Jack , Cade Brian E , Garaulet Marta , Kyle Simon D , Little Max A , Loudon Andrew S , Luik Annemarie I , Scheer Frank AJL , Spiegelhalder Kai , Tyrrell Jessica , Gottlieb Daniel J , Tiemeier Henning , Ray David W , Purcell Shaun M , Frayling Timothy M , Redline Susan , Lawlor Deborah A , Rutter Martin K , Weedon Michael N , Saxena Richa 
Published: April 2018

AbstractSleep is an essential homeostatically-regulated state of decreased activity and alertness conserved across animal species, and both short and long sleep duration associate with chronic disease and all-cause mortality1,2. Defining genetic contributions to sleep duration could point to regulatory mechanisms and clarify causal disease relationships. Through genome-wide association analyses in 446,118 participants of European ancestry from the UK Biobank, we discover 78 loci for self-reported sleep duration that further impact accelerometer-derived measures of sleep duration, daytime inactivity duration, sleep efficiency and number of sleep bouts in a subgroup (n=85,499) with up to 7-day accelerometry. Associations are enriched for genes expressed in several brain regions, and for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission, catecholamine production, synaptic plasticity, and unsaturated fatty acid metabolism. Genetic correlation analysis indicates shared biological links between sleep duration and psychiatric, cognitive, anthropometric and metabolic traits and Mendelian randomization highlights a causal link of longer sleep with schizophrenia.
Key analysis of the dairy value chain in Vietnam: the case of Bavi
Authors: Nguyen Viet Khoi , Thi Hai Yen Hoang , Van Khai Tong , To Linh Huong , Duc Nguyen Tien 
Published: April 2018

Purpose
The purpose of this paper is to find out the distribution of benefits, costs, and value added among the actors and problems in the practical management in dairy milk value chain, especially in one of the most important dairy areas in Vietnam to see how they upgrade in the value chain.

Design/methodology/approach
A survey was carried out in Bavi, Hanoi where a large amount of fresh milk is produced annually. The content of the survey was built before conducting in Bavi with 160 questionnaires. The questionnaires were based on the criteria which reflect the main objectives of the paper such as the actor’s profits and costs, the relationship among these actors, and the advantages and disadvantages in the dairy milk’s value chain. Some part of results of the paper was evaluated by conducting interviews with the relevant target groups in the value chain of dairy milk. Data collected were aggregated and analyzed by SPSS20, Excel. The calculation of cost and profit margin of each actor in the chain was also be presented by a quantitative tool for value chain analysis.

Findings
This study pointed out the systemized problems in the value chain of one of the biggest dairy companies in Vietnam. This study revealed some wicked problems in the value chains of Vietnam under globalization.

Research limitations/implications
This study could not cover all of the detailed actors in the dairy value chain.

Originality/value
The value of income in the chain is distributed unequally. The benefits that farmers receive are inadequate with the costs they have to pay. This is a particular chain, in which the main factors boosting the chain are factories, and an increase in revenue also reflects the benefits of them. The result is that the value added in the chain is also biased toward the dairy plant. The paper also pointed out the shortcomings in the cost calculation of farmers. All the expenses, such as wages and the opportunity cost, are calculated in the total cost of the dairy plant, whereas dairy farmers do not mention these costs. Thus, in terms of benefits, farmers suffer more disadvantages, thus they should be received more value. In terms of management, Bavi’s authorities could not manage the output of milk in the perfect way. The lax management has led to a series of counterfeit goods that appear on the market today. These low-quality products are sold right on the highway and the Bavi’s tourist destination.
Pea leafminer Liriomyza huidobrensis (Diptera: Agromyzidae) uses vibrational duets for efficient sexual communication
Authors: Ge Jin , Wei Jia‐Ning , Zhang Ding‐Jie , Hu Chun , Zheng De‐Zhi , Kang Le 
Published: April 2018

AbstractThe pea leafminer (Liriomyza huidobrensis) is a notorious pest of vegetables and ornamental plants worldwide. Despite a large number of studies on its biology and ecology, the courtship behavior and sexual communication of this species remain unclear. Here, we studied vibrational communication in the sexual interaction of the pea leafminer. On host plant leaves, females and males behaviorally displayed the bobbing‐quivering alternation, which finally led to copulation. Moreover, records of laser vibrometry revealed three‐signal duets underlying the behavioral alternation. Sexually mature males spontaneously emitted calls (MCs) to initiate the duets. The females rapidly responded to MCs by emitting replies (FRs) that are longer in duration. The FRs further triggered male replies (MRs) in their search for potential partners. Leafminer‐produced vibrational signals convey efficient information to partners and generate pair formation on stretched substrates, such as plant leaves and nylon mesh, but cannot elicit responses on dense substrates, such as glass and plastic. Vibrational playbacks of both MCs and FRs can elicit replies in females and males, respectively. This study completely characterizes substrate‐borne vibrational duets in a dipteran insect. The discovery of vibrational sex signals in the pea leafminer provides new insights for the development of novel approaches to control the pest and its relative species.
Science and Technology and the President's Crime Commission
Authors: Blumstein Alfred 
Published: April 2018

AbstractThe U.S. President's Commission on Law Enforcement and Administration of Justice added a Task Force on Science and Technology as somewhat of an afterthought because there had then been very little interaction between science and technology and the criminal justice system (CJS). The task force focused on the CJS as a whole and interactions among its parts, with an important emphasis on analysis of the operating systems and on the important potential role of information systems as the technology advanced. The potential applications of contemporary information and electronic technologies is considerable, especially for assessing risk and needs of identified offenders and for providing relevant information wherever needed. There is urgent need for scientific evaluation of many of the positive and negative aspects of the operation of the CJS and of the potential for new technologies.
Patent as a Quality Signal in Entrepreneurial Finance: A Look Beneath the Surface
Authors: Chen Shi , Meng Wei , Lu Haitian 
Published: April 2018

AbstractWe examine the value of patents on Chinese firms’ access to venture capital (VC). We find that the patent applications (grants) of firms significantly increase their likelihood of obtaining VC funding in the following year(s), particularly for high‐quality patents in high‐tech industries. Depending on investment, patent quantity significantly improves the size of VC investment and firm valuation. This effect is pronounced in first‐round investment, strong intellectual property protection regions, during periods of loose monetary policy, and state/corporate VC. Overall, we support the use of patent as a quality signal in attracting entrepreneurial finance outside the US and warrant the conditions it holds.
Letter: phenotype and natural history of elderly onset inflammatory bowel disease
Authors: Everhov Å. H. , Ludvigsson J. F. , Olén O. 
Published: April 2018

Linked ContentThis article is linked to Mañosa et al and Mañosa and Doménech papers. To view these articles visit https://doi.org/10.1111/apt.14494 and https://doi.org/10.1111/apt.14622.
Letter: vedolizumab for autoimmune liver disease associated inflammatory bowel disease—Authors’ reply
Authors: Christensen B. , Gibson P. R. , Rubin D. T. 
Published: April 2018

Linked ContentThis article is linked to Christensen et al and Pavlidis et al papers. To view these articles visit https://doi.org/10.1111/apt.14525 and https://doi.org/10.1111/apt.14603.
Are older people a vulnerable group? Philosophical and bioethical perspectives on ageing and vulnerability
Authors: Bozzaro Claudia , Boldt Joachim , Schweda Mark 
Published: April 2018

AbstractThe elderly are often considered a vulnerable group in public and academic bioethical debates and regulations. In this paper, we examine and challenge this assumption and its ethical implications. We begin by systematically delineating the different concepts of vulnerability commonly used in bioethics, before then examining whether these concepts can be applied to old age. We argue that old age should not, in and of itself, be used as a marker of vulnerability, since ageing is a process that can develop in a variety of different ways and is not always associated with particular experiences of vulnerability. We, therefore, turn to more fundamental phenomenological considerations in order to reconstruct from a first person perspective the intricate interconnections between the experiences of ageing and vulnerability. According to this account, ageing and old age are phenomena in which the basic anthropological vulnerability of human beings can manifest itself in an increased likelihood of harm and exploitation. Thus, we plead for a combined model of vulnerability that helps to avoid problems related to the current concepts of vulnerability. We conclude first that old age as such is not a sufficient criterion for being categorized as vulnerable in applied ethics, and second that reflections on ageing can help to develop a better understanding of the central role of vulnerability in human existence and in applied ethics.
Responsibility and age‐related dementia
Authors: Frantik Petr 
Published: April 2018

AbstractThis article identifies the assumption of responsibility as a basic need of human beings and applies the concept specifically to older people with dementia or Alzheimer's disease. It suggests a two‐level concept of responsibility, based on the approach of discourse ethicist Karl‐Otto Apel, as a promising approach to recognizing human diversity while at the same time respecting people's equal rights to participate in discourse. This concept can serve as a theoretical starting point for the construction of individually adapted types of responsibility. Furthermore, the article describes practical ideas (primarily the practice of doll therapy) that can enable people with dementia or Alzheimer's disease to assume responsibility. Direct communication and a reflective, sensitive consideration of each individual case are identified as important prerequisites for the inclusion of elderly people with dementia.
Toward a global geroethics – gerontology and the theory of the good human life
Authors: Ehni Hans‐Joerg , Kadi Selma , Schermer Maartje , Venkatapuram Sridhar 
Published: April 2018

AbstractGerontologists have proposed different concepts for ageing well such as ‘successful ageing’, ‘active ageing’, and ‘healthy ageing’. These conceptions are primarily focused on maintaining health and preventing disease. But they also raise the questions: what is a good life in old age and how can it be achieved? While medical in origin, these concepts and strategies for ageing well also contain ethical advice for individuals and societies on how to act regarding ageing and old age. This connection between gerontology and ethics is overlooked by both schools of thought. We thus develop this research programme for a systematic geroethics in four steps. First, we analyze ‘successful ageing’ as put forward by Rowe and Kahn as a paradigmatic example of a gerontological conception of ageing well. Then, in a second step, we move from criticisms within gerontology to an ethical perspective; in particular, we want to clarify the problem of the claim of universal validity of conceptions of the good life. In a third constructive step, we explain how the ‘capabilities approach’ could be applied in this context as a normative foundation for the implicit normative assumptions of gerontological conceptions of ageing well, such as a particular choice of functionings, the ethical relevance of human agency, and the resulting claims of individuals towards society. Finally, using a concept developed by the German philosopher Ursula Wolf, we systematically develop the different aspects of the connection between ageing well and the theory of the good life in their full complexity and show their interconnectedness.
Endoplasmic reticulum stress‐mediated autophagy protects against β,β‐dimethylacrylshikonin‐induced apoptosis in lung adenocarcinoma cells
Authors: Wang Haibing , Zhang Gaochenxi 
Published: April 2018

β,β‐Dimethylacrylshikonin (DMAS) is an anti‐cancer compound extracted from the roots of Lithospermum erythrorhizon. The present study aims to investigate the effects of DMAS on human lung adenocarcinoma cells in vitro and explore the mechanisms of its anti‐cancer action. We showed that DMAS markedly inhibited cell viability in a dose‐ and time‐dependent way, and induced apoptosis as well as autophagy in human lung adenocarcinoma cells. Furthermore, we found that DMAS stimulated endoplasmic reticulum stress and mediated autophagy through the PERK‐eIF2α‐ATF4‐CHOP and IRE1‐TRAF2‐JNK axes of the unfolded protein response in human lung adenocarcinoma cells. We also showed that the autophagy induced by DMAS played a prosurvival role in human lung adenocarcinoma cells and attenuated the apoptotic cascade. Collectively, combined treatment of DMAS and pharmacological autophagy inhibitors could offer an effective therapeutic strategy for lung adenocarcinoma treatment.
Improving the echocardiographic assessment of pulmonary pressure using the tricuspid regurgitant signal—The “chin” vs the “beard”
Authors: Kyranis Stephen J. , Latona Jilani , Platts David , Kelly Natalie , Savage Michael , Brown Martin , Hamilton‐Craig Christian , Scalia Gregory M. , Burstow Darryl 
Published: April 2018

AimTransthoracic echocardiography (TTE) is a fundamental investigation for the noninvasive assessment of pulmonary hemodynamics and right heart function. The aim of this study was to assess the correlation and agreement of Doppler calculation of right ventricular systolic pressure (RVSP) and pulmonary vascular resistance (PVR) using “chin” and “beard” measurements of tricuspid regurgitant velocity (TRVmax), with invasive pulmonary artery systolic pressure (PASP) andPVR.MethodsOne hundred patients undergoing right heart catheterisation (RHC) and near simultaneous transthoracic echocardiography were studied.TRVmaxwas recorded for “chin” measurement (distinct peakTRVmaxsignal) and where available (63 patients), “beard” measurement (higher indistinct peakTRVmaxsignal).ResultsMeasurableTRVsignal was obtained in 96 patients. MeanRVSPchin54.7 ± 22.7 mm Hg andRVSPbeard68.6 = 23 ± 26.3 mm Hg (P < .001). There was strong correlation between bothRVSPchinandRVSPbeardwith invasivePASP(Pearson'sr = .9,R2 = 0.82,P < .001 ‐r = .88,R = .78,P < .001, respectively.). Bland‐Altman analysis forRVSPchinandRVSPbeardshowed a mean bias of −0.5 mm Hg (95% limits of agreement −21.4 to 20.5 mm Hg) and −10.7 (95%LOA−35.5 to 14.2 mm Hg), respectively. Receiver operator characteristics ofTRVmax“chin” and “beard” for diagnosis of pulmonary hypertension was assessed with optimal cut‐offs being 2.8 m/s (sensitivity 93%, specificity 87%) and 3.2 m/s (sensitivity 91%, specificity 82%), respectively. There was similar correlation betweenPVRchinandPVRbeard(r = .87,R2 = 0.75,P < .001 andr = .86,R2 = 0.74,P < .001, respectively). At higherPVR, there was overestimation of calculatedPVRusingPVRbeard.ConclusionThe accuracy of noninvasive measurement of right heart pressures is increased using the “chin” in estimation of bothRVSPandPVR.
An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis
Authors: Mottin Vitória H. M. , Suyenaga Edna S. 
Published: April 2018

AbstractAcne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. The review was made through bibliographic search of the main databases (Science Direct, PubMed, Scielo, Medline) between September 2015 and June 2016. Acne lesions create an environment that facilitates the excess growth of Propionibacterium acnes (P. acnes). AD is related to an increase in the proportion of Staphylococcus aureus (S. aureus) during flare‐ups. Some microorganisms have been shown to act not only in the prevention but also in the competition for pathogenic microorganisms and beneficially affect the inflammatory process present in these conditions. Despite the high variety of tested bacteria, Staphylococcus, Streptococcus, Lactococcus, Lactobacillus, and Enterococcus are the ones which showed the highest potential to control acne, and Vitreoscilla filiformis (V. filiformis), Staphylococcus epidermidis (S. epidermidis), and species of Lactobacillus and Bifidobacterium in the treatment of AD. Many of these studies were in vitro, and more detailed research should be performed in order to prove the real efficacy and safety of probiotics in these situations. An interesting alternative seems to be the use of Bacteriocin‐like inhibitory substances produced by probiotics, responsible for their antimicrobial activity.
Heart rate variability parameters in children with ventricular preexcitation
Authors: Koca Serhat , Pac Feyza Aysenur , Mihcioglu Ajda , Eris Deniz , Cay Serkan , Ozeke Ozcan 
Published: April 2018

AbstractIntroductionThe autonomic nervous system has a regulatory effect on cardiac electrophysiology and arrhythmogenesis. We aimed to assess cardiac autonomic status using heart rate variability (HRV) parameters in children with ventricular preexcitation.MethodsThe electrocardiography, Holter monitoring, transesophageal electrophysiological study (TEEPS), and invasive electrophysiological study (EPS) results of ventricular preexcitation patients obtained over a 7‐year period in our clinic were evaluated. According to the TEEPS results, patients’ accessory pathway conduction was classified as adverse (n = 40) or nonadverse (n = 25). The HRV parameters of patients were compared according to tachycardia inducibility that assessed by TEEPS and EPS. Also, HRV parameters were compared in patients with adverse and nonadverse pathway conduction. Further, the HRV parameters of preexcitation patients were compared with those of healthy controls.ResultsLF/HF, the best measure of sympathovagal balance, was statistically higher in patients with adverse conduction than in patients without adverse conduction and controls (P = 0.001). The LF/HF ratio was higher in ventricular preexcitation patients with inducible tachycardia than those without in EPS (P = 0.001). In addition, the LF/HF ratio was higher in symptomatic ventricular preexcitation patients than asymptomatic ones (P = 0.001). No difference in HRV parameters was found between preexcitation patients and controls.ConclusionAutonomic tonus in patients with ventricular preexcitation may affect accessory pathway conduction properties, tachycardia inducibility, and symptomology. The indicator of sympathovagal balance, LF/HF ratio, increased in ventricular preexcitation patients with inducible tachycardia and those that were symptomatic.
Utilization of cold pressed chia seed oil waste in a low‐fat salad dressing as natural fat replacer
Authors: Akcicek Alican , Karasu Salih 
Published: April 2018

AbstractThe main aim of this study is to develop a low‐fat salad dressing by using cold‐press chia seed oil waste powder (CCWP). Formulation optimization was conducted by response surface methodology (RSM) based on the rheological and microstructural properties. All of the samples exhibited non‐Newtonian flow behavior, and storage modulus (G′) value was higher than loss modulus (G″) in the whole frequency range. The consistency coefficient (K) value of the samples was significantly affected by formulation (p < .05) and found as 0.552–15.87 Pa·sn. The optimum stabilizer, oil, emulsifier, and CCWP content are 0.33, 10, 1.12, and 2%, respectively. The samples formulated by CCWP showed a high G′ and zeta (ζ) potential values at a low oil and emulsifier content. The samples prepared with optimum formulation exhibited high stability and comparable recovery properties with commercial samples. This study suggested that CCWP could be used in a low‐fat salad dressing as a fat replacer.Practical applicationsThe trend in the consumption of low‐fat dressing and mayonnaise has increased in recent years due to some health problem from the overconsumption of fat. For the food industry, however, it can be a problem to develop reduced fat content emulsions without significant changes in texture, rheological, and organoleptic characteristics. Natural and commercial types of the fat replacers are used to develop rheological and sensory properties of the low‐fat emulsions. Several types of commercial fat replacers are used in the food industry to produce the desirable mouthfeel properties. However, the trend in finding the natural source of fat replacers has increased and alternatives should be improved to meet consumer expectancy. Chia seed waste obtained from the oil industry can be considered as a natural source of fat replacer due to its high polysaccharide and protein content. In this study, the potential use of CCWP was studied as a natural fat replacer.