bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the turbine scale on yaw control
Authors: Ciri Umberto , Rotea Mario A. , Leonardi Stefano 
Published: August 2018

AbstractYaw misalignment between the incoming wind and the rotor of a turbine causes a lateral displacement of the wake. This effect can be exploited to avoid or mitigate wake interactions in wind farms, so that power losses are minimized. We performed large‐eddy simulations to evaluate yaw control for a three‐turbine wind farm. We used two different turbine models to assess how the size of the turbine rotor affects the farm efficiency and the effectiveness of the control strategy. A utility‐scale wind turbine with rotor diameter of 126 m is compared with a scaled research wind turbine with rotor diameter of 27 m. In both cases, a model‐free algorithm is used to determine the turbine yaw set point, which maximizes total power production. The algorithm is the nested extremum‐seeking control (NESC), which allows for the coordinated optimization of the wind turbine operating points. The results achieved with NESC are validated by computing a static performance map for different yaw angles. NESC converges to optimal operating conditions, which are in good agreement with the static map benchmark. Numerical results show that a larger rotor diameter induces larger wake deflection, thus achieving higher power improvements. From the analysis of the turbine structural loads, an increase in damage equivalent load is observed for both the yawed turbine and the waked one. Present results suggest that there is a cost‐effective trade‐off between performance and loads for large turbines.
An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis
Authors: Sohn Winnie Y. , Portale Anthony A. , Salusky Isidro B. , Zhang Hao , Yan Lucy L. , Ertik Bella , Shahinfar Shahnaz , Lee Edward , Dehmel Bastian , Warady Bradley A. 
Published: August 2018

AbstractBackgroundCalcimimetics, shown to control biochemical parameters of secondary hyperparathyroidism (SHPT), have well-established safety and pharmacokinetic profiles in adult end-stage renal disease subjects treated with dialysis; however, such studies are limited in pediatric subjects.MethodsIn this study, the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cinacalcet were evaluated in children with chronic kidney disease (CKD) and SHPT receiving dialysis. Twelve subjects received a single dose of cinacalcet (0.25 mg/kg) orally or by nasogastric or gastric tube. Subjects were randomized to one of two parathyroid hormone (PTH) and serum calcium sampling sequences: [(1) 2, 8, 48 h; or (2) 2, 12, 48 h] and assessed for 72 h after dosing.ResultsMedian plasma cinacalcettmaxwas 1 h (range 0.5–4.0 h); mean (SD)Cmaxand AUClastwere 2.83 (1.98) ng/mL and 11.8 (8.74) h*ng/mL, respectively; mean (SD) half-life (t1/2) was 3.70 (2.57) h. Dose adjustments, based upon body weight (mg/kg), minimized the effects of age, body weight, body surface area, and body mass index on cinacalcet PK. Reductions in serum PTH levels from baseline were observed at 2 to 8 h post-dose (median 10.8 and 29.6%, respectively), returned towards baseline by 12–72 h and were inversely related to changes in the plasma cinacalcet PK profile. Single-dose cinacalcet was well-tolerated with no unexpected safety findings and a PK/PD, safety profile similar to adults.ConclusionsIn conclusion, a single 0.25 mg/kg dose of cinacalcet was evaluated to be a safe starting dose in these children aged < 6 years.
FAITH AND EPISTEMOLOGY
Authors: Ichikawa Jonathan Jenkins 
Published: August 2018

ABSTRACTI offer an epistemic framework for theorising about faith. I suggest that epistemic faith is a disposition to believe or infer according to particular methods, despite a kind of tendency to perceive an epistemic shortcoming in that method. Faith is unjustified, and issues into unjustified beliefs, when the apparent epistemic shortcomings are actual; it is justified when the epistemic worries are unfounded.Virtuous faith is central to a great deal of epistemology. A rational agent will manifest faith in their perceptual abilities, in determining which experts and testifiers to trust, in their a priori reasoning, and in the epistemic capacities that are specific to their social environment. To ignore faith is to ignore a crucial element of our social and individualistic epistemic lives.One exercises faith when one forms beliefs despite a kind of apparent epistemic shortcoming, which may or may not correspond to a genuine weakness in evidential support. For example, standing on a bridge one knows to be safe, despite one's natural but irrational fear, can manifest a kind of epistemic faith. So too can forming perceptual beliefs, or engaging in logical inferences, despite lacking a dialectically satisfying response to skeptical arguments. The same goes for beliefs that are informed by one's ideological stance – these too count as manifestations of faith, and under some circumstances, such faith is epistemically appropriate. One upshot of my project will be that an intuitively appealing neutrality ideal for education and discourse is untenable. I'll conclude with some discussion of practical questions about whether, when, and why it can be worthwhile engaging seriously with people who have radically opposed views and frameworks.
Optimal mixing in two-dimensional stratified plane Poiseuille flow at finite Péclet and Richardson numbers
Authors: Marcotte F. , Caulfield C. P. 
Published: August 2018

We consider the nonlinear optimisation of irreversible mixing induced by an initial finite amplitude perturbation of a statically stable density-stratified fluid with kinematic viscosity $\unicode[STIX]{x1D708}$ and density diffusivity $\unicode[STIX]{x1D705}$. The initial diffusive error function density distribution varies continuously so that $\unicode[STIX]{x1D70C}\in [\bar{\unicode[STIX]{x1D70C}}-\unicode[STIX]{x1D70C}_{0}/2,\bar{\unicode[STIX]{x1D70C}}+\unicode[STIX]{x1D70C}_{0}/2]$. A constant pressure gradient is imposed in a plane two-dimensional channel of depth $2h$. We consider flows with a finite Péclet number $Pe=U_{m}h/\unicode[STIX]{x1D705}=500$ and Prandtl number $Pr=\unicode[STIX]{x1D708}/\unicode[STIX]{x1D705}=1$, and a range of bulk Richardson numbers $Ri_{b}=g\unicode[STIX]{x1D70C}_{0}h/(\bar{\unicode[STIX]{x1D70C}}U^{2})\in [0,1]$ where $U_{m}$ is the maximum flow speed of the laminar parallel flow, and $g$ is the gravitational acceleration. We use the constrained variational direct-adjoint-looping (DAL) method to solve two optimisation problems, extending the optimal mixing results of Foures et al. (J. Fluid Mech., vol. 748, 2014, pp. 241–277) to stratified flows, where the irreversible mixing of the active scalar density leads to a conversion of kinetic energy into potential energy. We identify initial perturbations of fixed finite kinetic energy which maximise the time-averaged perturbation kinetic energy developed over a finite time interval, and initial perturbations that minimise the value (at a target time, chosen to be $T=10$) of a ‘mix-norm’ as first introduced by Mathew et al. (Physica D, vol. 211, 2005, pp. 23–46), further discussed by Thiffeault (Nonlinearity, vol. 25, 2012, pp. 1–44) and shown by Foures et al. (2014) to be a computationally efficient and robust proxy for identifying perturbations that minimise the long-time variance of a scalar distribution. We demonstrate, for all bulk Richardson numbers considered, that the time-averaged kinetic-energy maximising perturbations are significantly suboptimal at mixing compared to the mix-norm minimising perturbations, and also that minimising the mix-norm remains (for density-stratified flows) a good proxy for identifying perturbations which minimise the variance at long times. Although increasing stratification reduces the mixing in general, mix-norm minimising optimal perturbations can still trigger substantial mixing for $Ri_{b}\lesssim 0.3$. By considering the time evolution of the kinetic energy and potential energy reservoirs, we find that such perturbations lead to a flow which, through Taylor dispersion, very effectively converts perturbation kinetic energy into ‘available potential energy’, which in turn leads rapidly and irreversibly to thorough and efficient mixing, with little energy returned to the kinetic-energy reservoirs.
An elaborate experiment on the single-mode Richtmyer–Meshkov instability
Authors: Liu Lili , Liang Yu , Ding Juchun , Liu Naian , Luo Xisheng 
Published: August 2018

High-fidelity experiments of Richtmyer–Meshkov instability on a single-mode air/$\text{SF}_{6}$ interface are carried out at weak shock conditions. The soap-film technique is extended to create single-mode gaseous interfaces which are free of small-wavelength perturbations, diffusion layers and three-dimensionality. The interfacial morphologies captured show that the instability evolution evidently involves the smallest experimental uncertainty among all existing results. The performances of the impulsive model and other nonlinear models are thoroughly examined through temporal variations of the perturbation amplitude. The individual growth of bubbles or spikes demonstrates that all nonlinear models can provide a reliable forecast of bubble development, but only the model of Zhang & Guo (J. Fluid Mech., vol. 786, 2016, pp. 47–61) can reasonably predict spike development. The distinct images of the interface morphology obtained also provide a rare opportunity to extract interface contours such that a spectral analysis of the interfacial contours can be performed, which realizes the first direct validation of the high-order nonlinear models of Zhang & Sohn (Phys. Fluids, vol. 9, 1997, pp. 1106–1124) and Vandenboomgaerde et al. (Phys. Fluids, vol. 14 (3), 2002, pp. 1111–1122) in terms of the fundamental mode and high-order harmonics. It is found that both models show a very good and almost identical accuracy in predicting the first two modes. However, the model of Zhang & Sohn (1997) becomes much more accurate in modelling the third-order harmonics due to the fewer simplifications used.
Influence of increasing surface melt over decadal timescales on land-terminating Greenland-type outlet glaciers
Authors: GAGLIARDINI OLIVIER , WERDER MAURO A. 
Published: August 2018

ABSTRACTOver recent decades, Greenland ice sheet surface melt has shown an increase both in intensity and spatial extent. Part of this water probably reaches the bed and can enhance glacier speed, advecting a larger volume of ice into the ablation area. In the context of a warming climate, this mechanism could contribute to the future rate of thinning and retreat of land-terminating glaciers of Greenland. These changes in ice flow conditions will in turn influence surface crevassing and thus the ability of water to reach the bed at higher elevations. Here, using a coupled basal hydrology and prognostic ice flow model, the evolution of a Greenland-type glacier subject to increasing surface melt is studied over a few decades. For different scenarios of surface melt increase over the next decades, the evolution of crevassed areas and the ability of water to reach the bed is inferred. Our results indicate that the currently observed crevasse distribution is likely to extend further upstream which will allow water to reach the bed at higher elevations. This will lead to an increase in ice flux into the ablation area which, in turn, accelerates the mass loss of land-terminating glaciers.
Heart rate and high frequency heart rate variability during stress as biomarker for clinical depression. A systematic review
Authors: Schiweck Carmen , Piette Deborah , Berckmans Daniel , Claes Stephan , Vrieze Elske 
Published: August 2018

AbstractThe interaction of physical and mental vulnerability and environmental constraints is thought to foster the development of psychiatric disorders such as major depressive disorder (MDD). A central factor in the development of psychopathology is mental stress. Despite some evidence for parasympathetic withdrawal and sympathetic overactivity in MDD, the psychophysiological response to stress in depression is not clear-cut. Given the growing interest in heart rate and heart rate variability as indicators for remote monitoring of patients, it is important to understand how patients with MDD react to stress in a laboratory-controlled environment. We conducted a systematic review of studies using electrocardiography to derive heart rate and heart rate variability during stress in patients with clinical depression. We focused on well-validated stress tasks- the mental arithmetic stress task, the Trier social stress task and public speaking task- to minimize confounding effects due to the nature of the stressor. The majority of studies found hypo-reactivity during stress as a hallmark of depression as evidenced by lower fluctuation in heart rate and heart rate variability in the high-frequency band. We address the potential underlying biological mechanisms, the influence of covariates on these measures and briefly discuss the specificity and potential for remote monitoring by using these variables.
NUDGE VERSUS BOOST: A DISTINCTION WITHOUT A NORMATIVE DIFFERENCE
Authors: Sims Andrew , Müller Thomas Michael 
Published: August 2018

Abstract:Behavioural public policy (BPP) has come under fire by critics who claim that it is illiberal. Some authors recently suggest that there is a type of BPP – boosting – that is not as vulnerable to this normative critique. Our paper challenges this claim: there's no non-circular way to draw the distinction between nudge and boost that would make the normative difference required to infer the permissibility of a policy intervention from its type-membership. We consider two strategies: paradigmatic examples and causal mechanisms. We conclude by sketching some suggestions about the right way to approach the normative issues.
Emerging ofptxP3 lineage inBordetella pertussis strains circulating in a population in northeastern Mexico
Authors: Gutiérrez-Ferman J. L. , Villarreal-Treviño L. , Ramírez-Aranda J. M. , Camacho-Ortiz A. , Ballesteros-Elizondo M. R. , Moreno-Juárez M. R. , Mendoza-Olazarán S. , de la O Cavazos M. E. , Villarreal-Pérez J. Z. , Gómez-Govea M. A. , Garza-González E. 
Published: August 2018

AbstractWe determined the molecular epidemiology ofBordetella pertussisisolates to evaluate its potential impact on pertussis reemergence in a population of Mexico. Symptomatic and asymptomatic cases were included. Pertussis infection was confirmed by culture and real-time polymerase chain reaction (PCR). SelectedB. pertussisisolates were further analysed; i.e. clonality was analysed by pulsed-field gel electrophoresis (PFGE) andptxP-ptxA, prn,fim2 andfim3 typing was performed by PCR and sequencing. Out of 11 864 analysed samples, 687 (5.8%) were positive for pertussis, with 244 (36%) confirmed by both culture and PCR whereas 115 (17%) were positive only by culture and 328 (48%) were positive only by PCR. One predominant clone (clone A,n= 62/113; 55%) and three major subtypes (A1, A2 and A3) were identified by PFGE. All 113 selected isolates had the allelic combinationptxP3-ptxA1.The predominant clone A and the three major subtypes (A1, A2 and A3) corresponded to the emerging genotypesptxP3-ptxA1-prn2-fim2-1-fim3-2 andptxP3-ptxA1-prn2-fim2-1-fim3-1. In conclusion, the presence of an endemic clone and three predominant subtypes belonging to the genotypesptxP3-ptxA1-prn2-fim2-1-fim3-2andptxP3-ptxA1-prn2-fim2-1-fim3-1were detected. This finding supports the global spread/expansion reported for these outbreaks associated genotypes.
Implementing large Foot and Mouth Disease vaccination programmes for smallholder farmers: lessons from Lao PDR
Authors: Nampanya S. , Khounsy S. , Abila R. , Windsor P. A. 
Published: August 2018

AbstractThis study assessed smallholder finances and their attitudes towards the Foot and Mouth Disease (FMD) vaccination programme, when 1 620 000 vaccine doses were provided for strategic administration in large ruminants in FMD ‘high-risk’ areas in Laos between 2012 and 2016. Farmers (n= 168) in the provinces of Xayyabouli (XYL), Xiengkhoung (XK) and Huaphan (HP), were interviewed. Over 91% of the farmers responded that their livestock were vaccinated for FMD, with over 86% ranking FMD vaccination as a good or very good intervention. No FMD cases were reported from the vaccinated provinces after May 2013. Examination of the total income per household in XYL, XK and HP indicated earnings of US$5060(±650), US$4260(±294) and US$1691(±676), respectively (P= 0.001), with 23%, 28% and 68% of the total incomes from annual sales of large ruminant, respectively. Of the farmers in XYL, XK and HP, 83%, 93% and 70% (P= 0.009) said their annual income increased compared with 2012, and 47%, 64% and 41%, respectively (P= 0.005), indicated this increase was from additional large ruminant sales. The study indicated that this large FMD vaccination programme was well regarded by participating farmers and may have provided satisfactory suppression of the disease in Laos, despite not achieving the preferred vaccination coverage. Continuation of the vaccination programme in FMD high-risk areas is suggested as desirable.
Learning from a clinical microsystems quality improvement initiative to promote integrated care across a falls care pathway
Authors: Gerrish Kate , Keen Carol , Palfreyman Judith 
Published: August 2018

Abstract

Aim
To identify learning from a clinical microsystems (CMS) quality improvement initiative to develop a more integrated service across a falls care pathway spanning community and hospital services.

Background
Falls present a major challenge to healthcare providers internationally as populations age. A review of the falls care pathway in Sheffield, United Kingdom, identified that pathway implementation was constrained by inconsistent co-ordination and integration at the hospital–community interface.

Approach
The initiative utilised the CMS quality improvement approach and comprised three phases. Phase 1 focussed on developing a climate for change through engaging stakeholders across the existing pathway and coaching frontline teams operating as microsystems in quality improvement. Phase 2 involved initiating change by working at the mesosystem level to identify priorities for improvement and undertake tests of change. Phase 3 engaged decision makers at the macrosystem level from across the wider pathway in achieving change identified in earlier phases of the initiative.

Findings
The initiative was successful in delivering change in relation to key aspects of the pathway, engaging frontline staff and decision makers from different services within the pathway, and in building quality improvement capability within the workforce. Viewing the pathway as a series of interrelated CMS enabled stakeholders to understand the complex nature of the pathway and to target key areas for change. Particular challenges encountered arose from organisational reconfiguration and cross-boundary working.

Conclusion
CMS quality improvement methodology may be a useful approach to promoting integration across a care pathway. Using a CMS approach contributed towards clinical and professional integration of some aspects of the service. Recognition of the pathway operating at meso- and macrosystem levels fostered wider stakeholder engagement with the potential of improving integration of care across a range of health and care providers involved in the pathway.
Ambient Noise Tomography of the Shandong Province and its Implication for Cenozoic Intraplate Volcanism in Eastern China
Authors: Li Cuilin , Chen Chuanxu , Dong Dongdong , Kuponiyi Ayodeji Paul , Dosso Stan E. , Su Daolei 
Published: August 2018

AbstractNew images of shear wave velocity (VS) structure of the crust and uppermost mantle in the Shandong province of China are presented based on inversion of ambient seismic noise data from 47 broadband stations. Interstation Rayleigh wave phase‐velocity dispersion curves for periods of 1–40 s are obtained from noise cross correlations between stations. Two‐dimensional phase‐velocity maps at periods of 5–30 s are obtained by tomographic inversion of these dispersion curves, which are then inverted for 3‐D Vs heterogeneity to ~80‐km depth. Our results show clear indications of Moho uplift and crustal thinning beneath the northern segment of the Yishu fault zone and the Jiaobei uplift, thus providing seismological evidence for the steep geometry and deep penetration of the fault system. Instead of large‐scale, low‐velocity anomalies beneath eastern China as imaged by previous regional tomography, our high‐resolution Vs results reveal fine‐scale focused low‐velocity anomalies beneath the isolated Cenozoic basalts. There are strong spatial correlations between the narrow low Vs zones in the uppermost mantle and the thinned crust, as well as the locations of the isolated Cenozoic volcanism in the study area. Our results suggest that the asthenosphere upwelling possibly originating from the stagnant Pacific slab is focused into localized features at 50‐ to 80‐km depth that supply the isolated Cenozoic volcanoes of the eastern China continental margin.
Spatiotemporal Variation of Mantle Viscosity and the Presence of Cratonic Mantle Inferred From 8 Years of Postseismic Deformation Following the 2010 Maule, Chile, Earthquake
Authors: Li Shaoyang , Bedford Jonathan , Moreno Marcos , Barnhart William D. , Rosenau Matthias , Oncken Onno 
Published: August 2018

AbstractPostseismic displacements following great subduction earthquakes show significant long‐wavelength and time‐dependent patterns caused primarily by transient viscoelastic relaxation processes occurring broadly at depth. However, the Earth's viscosity structure and time‐dependent variations are still poorly understood, especially in the years immediately following a great earthquake. Here we investigate the spatiotemporal variation of mantle viscosity proximal and distal to the southern Andes using 8 years of continuous high‐resolution GPS observations following the 2010 Mw 8.8 Maule earthquake in south Central Chile. We remove the potential influences of relocking and afterslip on far‐field GPS displacements and estimate viscosities that can explain the 3‐D displacements. The optimal viscosity structure exhibits a low‐viscosity (~1018Pa s) mantle beneath the Andean volcanic arc and high‐viscosity (>1022Pa s) cratonic mantle, indicating a dependence of transient viscosity on temperature. Comparisons of the viscosity distributions at different times show that mantle viscosities increase with time throughout the study region. Viscosity increase is generally fastest in the mantle wedge beneath the Andes and slows down with increasing distance from the source region of the Maule earthquake. Such temporal viscosity evolution may indicate a stress dependence of the viscosity proximal to the rupture zone, while regions east of the Andes act as a relatively rigid body (i.e., cratonic mantle) with much higher viscosity. Our results thus suggest that both temperature structure and stress state contribute to spatiotemporal variations of the mantle viscosity. Heterogeneous spatiotemporal variations of viscosity seem to control the expansion and duration of the postseismic deformation and therefore the postseismic stress evolution.