bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey on access control mechanisms for cloud computing
Authors: El Sibai Rayane , Gemayel Nader , Bou Abdo Jacques , Demerjian Jacques 
Published: August 2019

AbstractCloud computing is an Internet‐based computing where the information technology resources are provided to end users following their request. With this technology, users and businesses can access programs, storage, and application development platforms through the Internet and via the services offered by the cloud service providers (CSPs). One of the biggest obstructions in the cloud computing environment is data security. Actually, the data are dispersed across multiple machines and storage devices such as servers, computers, and various mobile devices. The uncontrolled access to these resources and data leads to many important data security risks for the end users. In this way, and in order to ensure the reliability of the cloud and the trust of the users regarding this environment, controlling access to data and resources as well as protecting and ensuring their security becomes a critical task for CSPs. In this work, we present a comprehensive review of existing access control mechanisms used in the cloud computing environment. The advantages and disadvantages of each of these models are discussed and presented along with their analysis. Also, we study the cloud requirements of these models, and we evaluate existing control mechanisms against these requirements.
Endogenous opioid dependence after intermittent use of glucose, sodium chloride, and monosodium glutamate solutions
Authors: Sudakov Sergey K. , Bogdanova Natalia G. , Alekseeva Elena V. , Nazarova Galina A. 
Published: August 2019

AbstractIn 2002, Colantuoni et al described the possibility of dependency in rats after intermittent, excessive consumption of a 25% glucose solution over a one‐week period. We hypothesized that the intermittent consumption of any tasty solution can lead to endogenous opioid dependency. Another aim was to determine whether dependency is connected to the taste of the consumed substance or with its physiological significance. Rats were maintained on chow and cyclic glucose, NaCl, or monosodium glutamate (MSG) solution for 8 days. On day 9, after a 12‐hr deprivation period and administration of intraperitoneally (IP) naloxone, the general withdrawal index was calculated as the sum of teeth chattering, head shaking, forepaw tremors, and wet dog shakes. Motor activity was also documented. After the intermittent consumption of any tasty solution, rats were found to demonstrate signs of endogenous opioid dependence. The development of dependence was not related to taste preferences or the amount of solution consumed. Intermittent use of essential substance with a pleasant taste, as glucose and sodium chloride, leads to the rapid development of endogenous opioid dependence. Withdrawal syndrome following the consumption of MSG solution is associated with the presence of sodium ions in the MSG molecule.
The Pleistocene geoarchaeology and geochronology of Con Moong Cave, North Vietnam: Site formation processes and hominin activity in the humid tropics
Authors: McAdams Conor , Morley Mike W. , Fu Xiao , Kandyba Alexander V. , Derevianko Anatoly P. , Nguyen Dong T. , Doi Nguyen G. , Roberts Richard G. 
Published: August 2019

AbstractThis paper presents the results of geoarchaeological and geochronological investigations at Con Moong Cave, North Vietnam. Beneath the published, terminal Pleistocene sequence, recent excavations have uncovered a ~5 m stratigraphic sequence containing flaked stone artifacts and sedimentary features that indicate extensive post‐depositional change. As the effects of tropical conditions on Pleistocene cave sediments are poorly resolved, a range of complementary techniques was selected to reconstruct the nature of on‐site sedimentation and occupation, while assessing the taphonomy of archaeological and palaeoecological materials. Our approach incorporates microstratigraphic, geochemical and sedimentological analyses, using optically stimulated luminescence (OSL) dating to estimate the time of sediment deposition in the cave. This case study has broad application to tropical zones worldwide. Sedimentation began in early Marine Isotope Stage (MIS) 4, while micromorphologically observed human occupation commenced before 42 thousand years ago (ka). By placing our results within the context of published, high‐resolution regional records of climate, we demonstrate that on‐site rhythms of Pleistocene occupation correlated with environmental changes in the region. During MIS 3, episodic abandonment of the site coincided with periods of drier conditions, while rapid climate fluctuations in MIS 2 corresponded with short‐lived occupation events and a switch to predominantly geogenic deposition in the cave.
Could oxalate‐extractable phosphorus replace phosphorus fractionation schemes in soil phosphorus prospections?—A case study in the prehistoric Milseburg hillfort (Germany)
Authors: Weihrauch Christoph , Schupp Alexander , Söder Ulrike , Opp Christian 
Published: August 2019

AbstractA geoarchaeological soil phosphorus (P) prospection is used to identify a gate within the prehistoric rampart of the Milseburg hillfort (Hesse, Germany). This study compares the application of a P fractionation scheme and P extraction with ammonium‐oxalate. We hypothesized that oxalate‐extractable P (P‐ox) and the related degree of P saturation (DPS) could replace the more expensive and time‐consuming fractionation schemes for geoarchaeological investigations. Comparing the results, the P fractionation helped to verify the existence of another section of the prehistoric ramparts and to identify the location of a gate within it. It also helped to discover the archaeologically relevant soil depths in the investigated area. This information could not be retrieved from the P‐ox data alone. Soil P‐ox contents and DPS values are relatively unspecific with regard to prehistoric land use. However, DPS at least indicates settled versus unsettled areas. Still, the results of the P fractionation more clearly delineate Iron Age land use areas including settlement, non‐settlement, rampart, and rampart gap (probable gate). Thus, in geoarchaeological contexts, this method seems to be preferable to a singular P‐ox extraction. However, for better results, P‐ox determination could be integrated into a P fractionation scheme.
The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation
Authors: Chao Hann‐Hsiang , Schonewolf Caitlin A. , Tan Erik X. , Swisher‐McClure Samuel , Ghiam Alireza F. , Weinstein Gregory S. , O'Malley Bert W. , Chalian Ara A. , Rassekh Christopher H. , Newman Jason G. , Cohen Roger B. , Bauml Joshua M. , Aggarwal Charu , Lin Alexander , Lukens John N. 
Published: August 2019

AbstractBackgroundFor patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from surgery to completion of adjuvant therapy, “package time” impacts locoregional control (LRC). However, the significance of package time in HPV+ oropharyngeal SCC (OPSCC) is unknown.MethodsWe examined patients undergoing TORS resection with PORT for HPV+ OPSCC from January 2010 to December 2015 with ≥18 months follow‐up (n = 267). A cutoff of 15 weeks was used to delineate patients into short and long package time groups. LRC loss was defined as any recurrence after surgery.ResultsProlonged package time >15 weeks was associated with inferior LRC in this HPV+ OPSCC cohort, driven primarily by interval from surgery to PORT initiation. Multivariate analysis showed that package time and T classification are both independently associated with LRC.ConclusionsAmong HPV+ OPSCC, prolongation of package time appears to compromise LRC, but not survival.
Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG)
Authors: van Beek Dirk‐Jan , Nell Sjoerd , Pieterman Carolina R.C. , de Herder Wouter W. , van de Ven Annenienke C. , Dekkers Olaf M. , van der Horst‐Schrivers Anouk N. , Drent Madeleine L. , Bisschop Peter H. , Havekes Bas , Borel Rinkes Inne H. M. , Vriens Menno R. , Valk Gerlof D. 
Published: August 2019

AbstractBackground and objectivesGastrinomas are the most prevalent functioning neuroendocrine tumors (NET) in multiple endocrine neoplasia type 1 (MEN1). Guidelines suggest medical therapy in most patients, but surgery may be considered in a subgroup. Currently, factors to guide management are necessary. This population‐based cohort study assessed prognostic factors of survival in patients with MEN1‐related gastrinomas.MethodsPatients with MEN1 having gastrinomas were identified in the Dutch MEN1 database from 1990 to 2014 based on fasting serum gastrin (FSG) levels and/or pathology. Predictors of overall survival were assessed using Cox regression.ResultsSixty‐three patients with gastrinoma (16% of the MEN1 population) were identified. Five‐ and 10‐year overall survival rates were 83% and 65%, respectively. Prognostic factors associated with overall survival were initial FSG levels ≥20x upper limit of normal (ULN) (hazard ratio [HR], 6.2 [95% confidence interval, 1.7‐23.0]), pancreatic NET ≥2 cm (HR 4.5; [1.5‐13.1]), synchronous liver metastases (HR 8.9; [2.1‐36.7]), gastroduodenoscopy suspicious for gastric NETs (HR 12.7; [1.4‐115.6]), and multiple concurrent NETs (HR 5.9; [1.2‐27.7]).ConclusionLife expectancy of patients with MEN1 gastrinoma is reduced. FSG levels and pancreatic NETs ≥2 cm are prognostic factors. FSG levels might guide surveillance intensity, step‐up to additional diagnostics, or provide arguments in selecting patients who might benefit from surgery.
Discordance in prediction of prognosis among patients with intrahepatic cholangiocarcinoma: A preoperative vs postoperative perspective
Authors: Moro Amika , Paredes Anghela Z. , Farooq Ayesha , Sahara Kota , Tsilimigras Diamantis I. , Mehta Rittal , Endo Itaru , Guglielmi Alfredo , Aldrighetti Luca , Alexandrescu Sorin , Marques Hugo P. , Shen Feng , Koerkamp Bas G. , Sasaki Kazunari , Pawlik Timothy M. ,   other members of the International Intrahepatic Cholangiocarcinoma Study Group
Published: August 2019

AbstractBackgroundThe objective of the current study was to characterize patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative‐intent surgery with discordant preoperative and postoperative prediction scores and determine factors associated with prediction discrepancy.MethodsPatients who underwent hepatectomy for ICC between 1990 and 2016 were identified in a multi‐institutional international database. Preoperative and postoperative prognostic models were designed and discordant prognostic scores were identified. A multivariable logistic regression analysis was completed to determined factors associated with score discordance.ResultsAmong 1149 patients, those who had concordant prediction scores were older (median age, 60 vs 56), and more likely to have a smaller median tumor size (6.0 vs 7.5 cm) (all P < .05). On multivariable logistic analysis, patients with higher neutrophil‐lymphocyte ratio (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.09‐1.19), higher CEA levels (OR, 1.25; 95% CI, 1.04‐1.50), larger tumors (OR, 1.10; 95% CI, 1.04‐1.15) and suspicious lymph nodes (OR, 2.05; 95% CI, 1.25‐3.36) were more likely to have preoperative and postoperative score discordance. Older patients had decreased odds of having score discordance (OR, 0.98; 95% CI, 0.96‐0.99). Patients with score discordance had worse overall survival compared with patients with concordant scores (median:15.9 vs 21.7 months, P < .05).ConclusionScore discordance may reflect an aggressive variant of ICC that would benefit from early integration of multidisciplinary treatment strategies.
Duodenal GI stromal tumors: Is radical resection necessary?
Authors: Uppal Abhineet , Wang Mansen , Fischer Trevan , Goldfarb Melanie 
Published: August 2019

AbstractBackground and ObjectivesDuodenal gastrointestinal stromal tumors (GISTs) are rare tumors that pose a surgical challenge, and long‐term outcomes after resection have not been detailed outside of small case series. This study uses the National Cancer Database (NCDB) to examine the determinants of radical resection for duodenal GISTs as well as the impact of local vs radical resection on overall survival (OS).MethodsThe NCDB was queried for nonmetastatic duodenal GISTs from 2004 to 2014. Predictors of radical resection were determined using multivariate logistic regression stratified by extent of tumor involvement. Factors associated with OS were identified with Cox proportional regression analysis.ResultsTreatment at an academic center, size >5 cm, and extra‐duodenal extension were associated with radical resection. On multivariate analysis, radical resection was associated with decreased OS (HR, 1.93; P < .03). Systemic therapy, extra‐duodenal extension, grade, stage, mitoses, and receipt of systemic therapy did not impact OS.ConclusionLocal resection of duodenal GISTs is associated with improved OS compared to radical resection after controlling for tumor factors and systemic treatment. Traditional indicators of tumor aggressiveness were associated with radical resection, but not OS. When feasible, local resection should be considered for resection of duodenal GISTs.
Are authentic tourists happier? Examining structural relationships amongst perceived cultural distance, existential authenticity, and wellbeing
Authors: Yu Jibin , Li Hanliang , Xiao Honggen 
Published: August 2019

AbstractThe existential authenticity theory and eudaimonism theory imply that perceived cultural distance facilitates existential authenticity, which then conduces to hedonic and eudaimonic wellbeing. This study examined these presumptions basing on quantitative data collected through questionnaire survey in China. Results suggest that perceived cultural distance is not related to existential authenticity, and existential authenticity is positively related to hedonic and eudaimonic wellbeing. Hence, physically breaking away from one's home culture does not guarantee existential authenticity, and experiencing greater existential authenticity is related to correspondingly greater hedonic and eudaimonic wellbeing. Theoretical and practical implications of this research are also discussed.
Can fear be eaten? The emotional outcomes of consuming frightening foods or drinks
Authors: Du Jiangang , Zheng Qiuying , Hui Michael K. , Fan Xiucheng 
Published: August 2019

AbstractThis paper examines the emotional effects of consuming frightening foods or drinks. We argue that in addition to maintaining energy homeostasis and attaining pleasure, a third possible benefit of eating is the enhancement of perceived mastery over that which is eaten. Hence, the intake of frightening foods or drinks should increase a consumer's self‐confidence in dealing with fear. The findings of our three experimental studies confirm our counterintuitive predictions, namely that consuming frightening (vs. nonfrightening) foods or drinks leads to a significant reduction of fears arising from prior experiences of frightening activities and a significant increase in tolerance of prospective frightening activities. In addition, self‐confidence in dealing with fear is shown to significantly mediate the predicted effects of consuming frightening foods or drinks.
The marketing firm and co‐creation: An empirical study of marketer and customer's co‐creation process
Authors: Fagerstrøm Asle , Bendheim Liv Marie , Sigurdsson Valdimar , Pawar Sanchit , Foxall Gordon R. 
Published: August 2019

This study empirically investigates the marketer and customer's co‐creation process within the context of the marketing firm. Based on principles from bilateral contingencies, findings from a conjoint study (n = 98) indicate that utilitarian and informational reinforcing consequences from the marketer have a stronger impact on customers' co‐creation behavior relative to informational reinforcing consequences from other customers. Consequently, analyzing the impact of important reinforcing contingencies through the lens of bilateral contingencies expands our understanding of how and why co‐creation outcomes might occur. Also, a good co‐creation process may increase the business companies' research and intelligence and, as a consequence, strengthen their competitiveness.
A de novo variant in the X‐linked gene CNKSR2 is associated with seizures and mild intellectual disability in a female patient
Authors: Polla Daniel L. , Saunders Harriet R. , de Vries Bert B. A. , van Bokhoven Hans , de Brouwer Arjan P. M. 
Published: August 2019

AbstractBackgroundEight different deletions and point variants of the X‐chromosomal gene CNKSR2 have been reported in families with males presenting intellectual disability (ID) and epilepsy. Obligate carrier females with a frameshift variant in the N‐terminal protein coding part of CNKSR2 or with a deletion of the complete gene are not affected. Only for one C‐terminal nonsense variant, two carrier females were mildly affected by seizures without or with mild motor and language delay.MethodsExome sequencing was performed in one female child of a Dutch family, presenting seizures, mild ID, facial dysmorphisms, and abnormalities of the extremities. Potential causative variants were validated by Sanger sequencing. X‐chromosome‐inactivation (XCI) analysis was performed by methylation‐sensitive PCR and fragment‐length analysis of the androgen‐receptor CAG repeat polymorphism.ResultsWe identified a de novo variant, c.2304G>A (p.(Trp768*)), in the C‐terminal protein coding part of the X‐chromosomal gene CNKSR2 in a female patient with seizures and mild ID. Sanger sequencing confirmed the presence of this nonsense variant. XCI analysis showed a mild skewing of X inactivation (20:80) in the blood of our patient. Our variant is the second C‐terminal–affecting CNKSR2 variant described in neurologically affected females.ConclusionOur results indicate that CNKSR2 nonsense variants in the C‐terminal coding part can result in ID with seizures in female variant carriers.
Natural course of Fabry disease with the p. Arg227Ter (p.R227*) mutation in Finland: Fast study
Authors: Pietilä‐Effati Päivi , Saarinen Jukka T. , Löyttyniemi Eliisa , Autio Reijo , Saarenhovi Maria , Haanpää Maria K. , Kantola Ilkka 
Published: August 2019

AbstractBackgroundFabry disease is caused by a deficient or an absent alfa‐galactosidase A activity and is an X‐linked disorder that results in organ damage and a shortened life span, especially in males. The severity of the disease depends on the type of mutation, gender, skewed X‐chromosome inactivation, and other still unknown factors.MethodsIn this article, we describe the natural course of a common classic Fabry disease mutation, p.Arg227Ter or p.R227*, in Finland.ResultsFour males and ten females belonged to two extended families. The mean age was 46 years (SD 18.4). Six patients (43%) had cardiac hypertrophy, three patients (21%) had ischemic stroke, and none had severe kidney dysfunction. Three patients had atrial fibrillation; two patients who had atrial fibrillation also had pacemakers. All males over 30 years of age had at least one of the following manifestations: cardiac hypertrophy, stroke, or proteinuria. In females, the severity of Fabry disease varied from classic multiorgan disease to a condition that mimicked the attenuated cardiac variant. No one was totally asymptomatic without any signs of Fabry disease. Cardiac magnetic resonance imaging was performed on nine of 14 patients was the most sensitive for detecting early cardiac manifestations. Five patients (55%) had late gadolinium enhancement‐positive segments.ConclusionCardiac involvement should be effectively detected in females before considering them asymptomatic mutation carriers.
Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway
Authors: Ferramosca Alessandra , Treppiccione Lucia , Di Giacomo Mariangela , Aufiero Vera Rotondi , Mazzarella Giuseppe , Maurano Francesco , Gerardi Carmela , Rossi Mauro , Zara Vincenzo , Mita Giovanni , Bergamo Paolo 
Published: August 2019

ScopePolyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2‐related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Flavonoid‐rich concentrated extract from Prunus mahaleb (mahaleb concentrated fruit extract; MCFE) may act on oxido‐reductive homeostasis and hepatic lipid metabolism via Nrf2.Methods & ResultsMCFE ability to enhance the activity of Nrf2‐mediated antioxidant/detoxifying enzymes is investigated in liver and colon of BALB/c mice. After a 4‐week supplementation, macroscopic, histological, and biochemical signs of colitis are examined in mouse colon pulsed with 5% (w/v) dextran sodium sulfate (DSS). Untreated or DSS‐supplemented mice are used as negative or positive control. MCFE effect on liver lipid metabolism and its possible link with the Nrf2 pathway is investigated.MCFE intake increases antioxidant defenses in mice colon and its pretreatment blunts pathological signs of colitis, as compared to positive control. In the liver, the increase in antioxidant defenses is associated with enhanced oxidative metabolism and with higher levels of peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α) and of hemeoxygenase‐1 (HO‐1), in comparison with negative controls.ConclusionCytoprotective and hypolipidemic effect produced by MCFE intake results, at least in part, by the activation of the Nrf2 pathway.
Four element ultra‐wideband fractal multiple‐input multiple‐output antenna
Authors: Singhal Sarthak 
Published: August 2019

AbstractA four elements fractal antenna for UWB multiple‐input multiple‐output (MIMO) applications is presented. Each element comprises three iterations of inner tapered rectangular radiator and rectangular notch loaded coplanar waveguide rectangular ground planes. A rotated “+”shaped rectangular strip pair is introduced to enhance the isolation between two diagonally opposite elements. This antenna is operating over a frequency spectrum of 4.8‐19.4 with an intra‐element isolation of more than 15 dB. In addition to good radiation characteristics, desirable values of diversity performance parameters are achieved.
Numerically obtained vortices in granular media
Authors: Kolymbas Dimitrios , Bathaeian Iman 
Published: August 2019

SummaryWith our meshfree numerical code SPARC (Soft PARticle Code), which is based on strong solutions of the equations of equilibrium, we were able to derive vortex patterns ("turbulence") in deformations hitherto believed to be homogeneous. The formation of such vortices demonstrates the nonuniqueness of the corresponding boundary value problem. We present some evidence that such vortices can be related with ptygmatic folds, which are observed in rock.