bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary teams for the proper management of patients with genitourinary tumors: When topics set scientific societies’ agenda
Authors: Magnani Tiziana , Bracarda Sergio , D’Angelillo Rolando M. , Artibani Walter , Barni Sandro , Beretta Giordano , Brausi Maurizio , Caffo Orazio , Corvò Renzo , Gallucci Michele , Gunelli Roberta , Mirone Vincenzo , Novara Giacomo , Pinto Carmine , Russi Elvio , Santoni Riccardo , Tomirotti Maurizio , Volpe Alessandro , Conti Giario , Valdagni Riccardo 
Published: July 2018

Introduction: The multidisciplinary management of oncologic patients is identified as the bottom line element of quality in tumor care. Methods: In 2015, 7 Italian scientific societies representing the specialists involved in the diagnosis and treatment of genitourinary tumors joined efforts in the Italian uro-oncologic multidisciplinary teams (MDTs) project. The aims were to promote the reorganization of genitourinary cancer care, switching to a multidisciplinary approach, reach a consensus on the core elements for the setup of MDTs in genitourinary oncology, and support health policy makers and managers in remodeling of the assistance and care of uro-oncologic patients on a national level. Results: The first activity was the setup of 5 working groups, given the task of exploring selected topics: general principles, organization of MDTs, minimal requirements, economic evaluation, and relations with authorities. The groups participated in the writing of a document that was approved by the scientific societies and published on their web sites. Moreover, a few items summarizing the extensive document were approved in the first MDT Consensus Conference held in Milan in December 2015. Conclusions: The experience of this initial phase led to the opening of the team to other professionals and societies, in line with a correct management of patients with genitourinary tumors, which need a multidisciplinary as well as a multiprofessional approach with emerging techniques and procedures, and with a new project work package on genitourinary paths of care and indicators.
Biomechanical Strength of Rotator Cuff Repairs: A Systematic Review and Meta-regression Analysis of Cadaveric Studies
Authors: Shi Brendan Y. , Diaz Miguel , Binkley Matthew , McFarland Edward G. , Srikumaran Uma 
Published: July 2018

Background:Biomechanical cadaveric studies of rotator cuff repair (RCR) have shown that transosseous equivalent and double-row anchored repairs are stronger than other repair constructs.Purpose:To identify technical and procedural parameters that most reliably predict biomechanical performance of RCR constructs.Study Design:Systematic review.Methods:The authors systematically searched the EMBASE and PubMed databases for biomechanical studies that measured RCR performance in cadaveric specimens. The authors performed a meta-regression on the pooled data set with study outcomes (gap formation, failure mode, and ultimate failure load) as dependent variables and procedural parameters (eg, construct type, number of suture limbs) as covariates. Stratification by covariates was performed. An alpha level of .05 was used.Results:Data from 40 eligible studies were included. Higher number of suture limbs correlated with higher ultimate failure load (β = 38 N per limb; 95% CI, 28 to 49 N) and less gap formation (β = −0.6 mm per limb; 95% CI, −1 to −0.2 mm). Other positive predictors of ultimate failure load were number of sutures, number of mattress stitches, and use of wide suture versus standard suture. When controlling for number of suture limbs, we found no significant differences among single-row anchored, double-row anchored, transosseous equivalent, and transosseous repairs. Higher number of suture limbs and transosseous equivalent repair both increased the probability of catastrophic construct failure.Conclusion:This study suggests that the number of sutures, suture limbs, and mattress stitches in a RCR construct are stronger predictors of overall strength than is construct type. There is a need to balance increased construct strength with higher risk of type 2 failure.
Classical Political Economy and the Evolution of Central Banks: Endogenous Money and the Fiscal-Military State
Authors: Vernengo Matías 
Published: July 2018

The paper analyzes briefly the changing ideas on the role of money and banks from William Petty to Thomas Tooke, including the works of Adam Smith, David Ricardo, and Karl Marx. It analyzes the role of ideas in shaping the evolution of central bank regulation. Particular importance is given to the Bank of England’s inconvertibility period, from 1797 to 1821, and the ensuing debate in shaping Robert Peel’s Bank Act of 1844, which is often seen as the birth of modern central banking. The importance of the Say’s Law, and the inexistence of an alternative theory of the determination of output, is shown to play an essential role in the policy prescriptions of the so-called Bullionist authors, who won the debates that shaped central banking practices in the nineteenth century. The paper concludes with a brief analysis of what is a central bank according to the dominant (marginalist) mainstream of the profession, and what an alternative conception based on what may be termed classical-Keynesian political economy would be. JEL Classification: B10, N20, E58
The participation of people with dementia in the planning of their care and support: An integrative literature review
Authors: Read Sheridan T , Toye Christine , Wynaden Dianne 
Published: July 2018

Background People with dementia continue to voice concerns that health professionals are reluctant to engage with them about the planning of their care and support. Instead, their perspective is that such plans are often made by others and fail to reflect their wishes. Objective This review aimed to examine investigations of the participation of people living with dementia in the planning of their care and support, when they have also provided study data. Methods An integrative literature review was conducted to identify, critique, and synthesise relevant research findings. Eight electronic databases were searched to identify peer reviewed journal articles that met inclusion criteria. In addition, reference lists of included articles were searched, and a subject expert was consulted about any possible omissions. Results From the 346 articles accessed, seven met inclusion criteria for review. The quality appraisal showed that one article reported only pilot data; several more reported small sample sizes; and, in two instances, there was a lack of information about the psychometric properties of data collection tools and about recruitment and attrition rates. Conclusions There has been limited investigation of the participation of people with dementia in the planning of their support when they have also contributed research data. Findings provide some evidence of their participation by attending education programme, setting goals in cognitive rehabilitation therapy and contributing to advance care planning.
Transparency, Class Bias, and Redistribution: Evidence from the American States
Authors: Severson Alexander 
Published: July 2018

AbstractThis study employs state-level panel data between 1978 and 2000 to explore the relationship between transparency, media market penetration, class bias in voter participation, and welfare effort in the United States. I present empirical evidence that the effect of transparency—operationalized as state fiscal transparency—on state welfare effort is conditional on class bias in voter participation. Specifically, I present evidence that in states where transparency and class bias increased over time, state welfare effort significantly declined. These results are robust to the inclusion of controls for other determinants of redistribution that traditionally vary with geography such as governor partisanship, legislator ideology, citizen ideology, gross state product (GSP), and state demographic characteristics, and are robust across several alternate model specifications. My findings suggest that increased transparency does not automatically improve the condition of socioeconomically-disadvantaged citizens and that transparency may have welfare-reducing effects in societies with increasing participatory gulfs between the most and least advantaged citizens.
Imaging artifacts of Onyx and PHIL on conventional CT, cone-beam CT and MRI in an animal model
Authors: Vollherbst Dominik F , Otto Ruth , Do Thuy , Kauczor Hans U , Bendszus Martin , Sommer Christof M , Möhlenbruch Markus A 
Published: July 2018

Background and purpose A frequently reported drawback of ethylene vinyl alcohol copolymer-based liquid embolic agents is the production of artifacts in diagnostic imaging. New embolic agents, such as Precipitating hydrophobic injectable liquid (PHIL; MicroVention, Tustin, CA, USA), are supposed to induce significantly fewer artifacts. The purpose of this study is to assess the degree of artifacts induced by the liquid embolic agents Onyx (Medtronic Neurovascular, Irvine, CA, USA) and PHIL in conventional computed tomography (CT), cone-beam CT and magnetic resonance imaging (MRI) in an experimental in vivo model. Materials and methods In 10 pigs the rete mirabile was embolized with Onyx ( n = 5) or PHIL ( n = 5). After embolization, conventional CT, cone-beam CT and MRI were performed. The degree of artifacts was graded qualitatively (five-point scale; for CT and MRI) and quantitatively (HUs of well-defined regions of interest (ROIs); for CT only). Results Artifacts were significantly more severe for Onyx both in the qualitative (e.g. conventional CT: 2 versus 5 (medians); p = 0.008) and in the quantitative image analysis (e.g. cone-beam CT: standard deviation of a ROI near to the embolic agent cast, 94 HU versus 38 HU (medians); p = 0.008). Neither Onyx nor PHIL produced any apparent artifacts in MRI. Conclusion PHIL produces fewer artifacts than Onyx in conventional CT and cone-beam CT in an experimental in vivo model.
In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model
Authors: Samaniego Edgar A , Derdeyn Colin P , Hayakawa Minako , Hasan David , Ortega-Gutierrez Santiago 
Published: July 2018

Introduction Few liquid embolic materials are available for treatment of arteriovenous malformations. We describe the in vivo experience with the new PHIL low viscosity (LV) liquid embolic agent in a swine rete mirabile model. Methods Eight swine were treated. Two animals underwent embolization of a rete with PHIL LV and the contralateral rete with Squid 12 (euthanized the same day). Six animals underwent embolization of the right rete: two with balloon flow arrest (euthanized at 14 d) and four with a microcatheter alone (euthanized at 14 and 90 d). Performance characteristics of the embolic agents were evaluated. Microscopic and histological analysis of the harvested retia was performed. Macroscopic examinations and high contrast digital-based radiographs of the central nervous system were obtained. Results We did not experience any technical complication during embolization of each rete. Overall occlusion ability, on/off injection and ease to retrieve the microcatheter/balloon with PHIL LV were optimal. Fluoroscopic visualization of the PHIL LV cast was adequate to optimal. Average embolization time with flow arrest was 9.5 min versus 19.5 min with microcatheter plugging. Embolizations with PHIL LV required less volume and were shorter when compared to Squid 12. Subacute (14 d) and chronic (90 d) microscopic and histological analysis demonstrated minimal inflammatory changes in the perivascular tissues and permanent occlusion of the embolized vasculature. Conclusion In this swine rete model, the new PHIL LV embolic agent had an excellent embolization performance. Vessels embolized remained occluded up to 90 d from the procedure with minimal inflammatory changes.
Effect of hospital volume on outcomes of percutaneous peripheral atherectomy – An observational analysis from National Inpatient Sample
Authors: Patel Samir V , Sonani Rajesh , Patel Palak , Patel Mihir , Bhatt Parth , Badheka Apurva 
Published: July 2018

Background Although the published literature has reported an inverse association between hospital volume and outcomes of coronary interventions, sparse data are available for percutaneous peripheral atherectomy (PPA). The aim of our study was to examine the effect of hospital volume on outcomes of PPA. Methods Using the Nationwide Inpatient Sample (NIS) database of the year 2012, PPA with ICD-9 code of 17.56 was identified. The primary outcomes were mortality and amputation rates; secondary outcomes were peri-procedural complications, cost, and length of hospitalization and discharge disposition of the patient. Multivariate models were generated for predictors of the outcomes. Results We identified a total of 21,015 patients with mean age of 69.53 years, with 56% males. Higher hospital volume centers were associated with a significantly lower mortality (OR 0.42, 95% CI 0.30–0.57, p < 0.0001), amputation rates (5.34% vs. 9.32%, p < 0.0001), combined endpoint of mortality and complications (OR 0.53, 95% CI 0.49–0.58, p < 0.0001), shorter length of hospital stay (LOS) (4.86 vs. 6.79 days, p < 0.0001) and lower hospitalization cost ($23,062 vs. $30,794, p < 0.0001). Subgroup analysis for acute and chronic limb ischemia showed similar results. Conclusion Hospital procedure volume is an independent predictor of mortality, amputation rates, complications, LOS, and costs in patients undergoing PPA with an inverse relationship.
A workforce in jeopardy: identifying the challenges of ensuring a sustainable advanced HIV nursing workforce
Authors: Piercy Hilary , Bell Gill , Hughes Charlie , Naylor Simone , Bowman Christine 
Published: July 2018

Background HIV services in England face substantial challenges arising from financial pressures and changes to commissioning. A sustainable HIV specialist nursing workforce will be vital to enable them to respond to those challenges. Aims This paper examines the current workforce situation in HIV services across the country. Methods This mixed-method study involved semi-structured interviews with 19 key stakeholders and with 44 nurses/physicians from 21 purposively selected HIV services across England. Data were interpreted using a framework analysis approach. Results ‘Building a career in HIV nursing’ identified problems associated with retention and recruitment. Changes in commissioning are disrupting common career routes from sexual health to HIV nursing, and a perceived lack of a clear career pathway was seen as a barrier to recruitment. ‘Developing a specialist workforce’ explored the professional development of the current workforce, which was hampered by poor access to funding or study time for advanced study and the absence of an HIV-specific advanced nursing qualification. Conclusions The HIV nursing workforce, which provides an increasing proportion of HIV care, is facing serious recruitment and retention challenges. A strategic approach to workforce development and training is essential to overcome systemic barriers and secure the next generation of skilled practitioners.
The Anthropocene’s dating problem: Insights from the geosciences and the humanities
Authors: Nichols Kyle , Gogineni Bina 
Published: July 2018

The Anthropocene, generally defined, is the time when human activities have a significant impact on the Earth System. However, the natural sciences, the humanities, and the social sciences have different understandings of how and when human activities affected the Earth System. Humanities and social science scholars tend to approach the Anthropocene from a wide range of moral-political concerns including differential responsibility for the change in the Earth System and social implications going forward. Geologists, on the other hand, see their work as uninfluenced by such considerations, instead concerning themselves with empirical data that might point to a ‘golden spike’ in the geologic record – the spike indicating a change in the Earth System. Thus, the natural sciences and the humanities/social sciences are incongruent in two important ways: (1) different motivations for establishing a new geologic era, and (2) different parameters for identifying it. The Anthropocene discussions have already hinted at a paradigm shift in how to define geologic time periods. Several articles suggest a mid-20th century commencement of the Anthropocene based on stratigraphic relationships identified in concert with knowledge of human history. While some geologists in the Anthropocene Working Group have stated that the official category should be useful well beyond geology, they continue to be guided by the stratigraphic conventions of defining the epoch. However, the methods and motivations that govern stratigraphers are different from those that govern humanists and social scientists. An Anthropocene defined by stratigraphic convention would supersede many of the humanities/social science perspectives that perhaps matter more to mitigating and adapting to the effects of humans on Earth’s System. By this reasoning, the impetus for defining the Anthropocene ought to be interdisciplinary, as traditional geologic criteria for defining the temporal scale might not meet the aspirations of a broad range of Anthropocene thinkers.
Up-front rituximab maintenance improves outcome in patients with follicular lymphoma: a collaborative Nordic study
Authors: Madsen C. , Clausen M. R. , Plesner T. L. , Pasanen A. , Kuismanen T. , Bentzen H. H. , Jørgensen J. M. , Sillesen I. B. , Himmelstrup B. M. , Rønnov-Jessen D. , Jensen K. R. , Pettinger A. M. , Ludvigsen M. , Leppä S. , d’Amore F. A. 
Published: July 2018

Key PointsPatients who received R-chemo followed by MR had an improved 5-year PFS and OS independent of prognostic factors. A reduction of the risk of HT was observed among the MR patients of the training, but not of the validation, cohort.
Dyspnoea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact
Authors: Dangers Laurence , Montlahuc Claire , Kouatchet Achille , Jaber Samir , Meziani Ferhat , Perbet Sébastien , Similowski Thomas , Resche-Rigon Matthieu , Azoulay Elie , Demoule Alexandre 
Published: July 2018

Dyspnoea is a frequent and intense symptom in intubated patients, but little attention has been paid to dyspnoea during noninvasive mechanical ventilation in the intensive care unit (ICU).The objectives of this study were to quantify the prevalence, intensity and prognostic impact of dyspnoea in patients receiving noninvasive ventilation (NIV) for acute respiratory failure (ARF) based on secondary analysis of a prospective observational cohort study in patients who received ventilatory support for ARF in 54 ICUs in France and Belgium. Dyspnoea was measured by a modified Borg scale.Among the 426 patients included, the median (interquartile range) dyspnoea score was 4 (3–5) on admission and 3 (2–4) after the first NIV session (p=0.001). Dyspnoea intensity ≥4 after the first NIV session was associated with the Sequential Organ Failure Assessment Score (odds ratio (OR) 1.12, p=0.001), respiratory rate (OR 1.03, p=0.032), anxiety (OR 1.92, p=0.006), leaks (OR 2.5, p=0.002) and arterial carbon dioxide tension (OR 0.98, p=0.025). Dyspnoea intensity ≥4 was independently associated with NIV failure (OR 2.41, p=0.001) and mortality (OR 2.11, p=0.009), but not with higher post-ICU burden and altered quality of life.Dyspnoea is frequent and intense in patients receiving NIV for ARF and is associated with a higher risk of NIV failure and poorer outcome.
Jobs for Africa’s expanding youth cohort: a stocktaking of employment prospects and policy interventions
Authors: Betcherman Gordon , Khan Themrise 
Published: July 2018

AbstractYouth unemployment and underemployment are serious concerns in sub-Saharan Africa, especially given the region’s young population. The barriers young people face stem both from skills deficiencies and from weak fundamentals that constrain job creation more generally in the region. Employment interventions can mitigate some of these barriers. However, our stocktaking of these interventions suggests that existing programs are disproportionately focused on the formal wage sector and do not adequately reflect the reality that most young people work in agriculture, household enterprises, and self-employment and will continue to do so for the foreseeable future. Finally, better data and evaluation are needed for more effective interventions.
Complexes of α6β4 integrin and vimentin act as signaling hubs to regulate epithelial cell migration
Authors: Colburn Zachary T. , Jones Jonathan C. R. 
Published: July 2018

ABSTRACT
We find that clusters of β4 integrin, organized into distinct puncta, localize along vimentin filaments within lamellipodia at the cell edge of A549 cells, as assessed by interferometric photoactivated localization microscopy. Moreover, puncta and vimentin filaments exhibit a dynamic interplay in live cells, as viewed by structured-illumination microscopy, with β4 integrin puncta that associate with vimentin persisting for longer than those that do not. Interestingly, in A549 cells β4 integrin regulates vimentin cytoskeleton organization. When β4 integrin is knocked down there is a loss of vimentin filaments from lamellipodia. However, in these conditions, vimentin filaments instead concentrate around the nucleus. Although β4 integrin organization is unaffected in vimentin-deficient A549 cells, such cells move in a less-directed fashion and exhibit reduced Rac1 activity, mimicking the phenotype of β4 integrin-deficient A549 cells. Moreover, in vimentin-deficient cells, Rac1 fails to cluster at sites enriched in α6β4 integrin heterodimers. The aberrant motility of both β4 integrin and vimentin-deficient cells is rescued by expression of active Rac1, leading us to propose that complexes of β4 integrin and vimentin act as signaling hubs, regulating cell motility behavior.
Scepticaemia: The impact on the health system and patients of delaying new treatments with uncertain evidence; a case study of the sepsis bundle
Authors: Blythe Robin , Cook David , Graves Nicholas 
Published: July 2018

Background: A sepsis care bundle of intravenous vitamin C, thiamine, and hydrocortisone was reported to improve treatment outcomes. The data to support it are uncertain and decision makers are likely to be cautious about adopting it. The objective of this study was to model the opportunity costs in dollars and lives of waiting for better information before adopting the bundle. Methods: A decision tree was built using information from the literature. We modelled the impact of bundle adoption under three scenarios using a simulation in which the bundle was effective as reported in the primary trial, less effective based on other information, and ineffective. The measurements were health services costs, quality-adjusted life years, and transition probabilities. Results: If the bundle proves to be effective under either scenario, it will save billions of dollars and millions of life-years in the United States. This is the opportunity cost of delaying an adoption decision and waiting for better quality evidence. We suggest that hospital decision-makers consider implementing the bundle on a trial basis while monitoring costs and outcomes data even while the evidence base is uncertain. Conclusions: If the decision maker is unwilling to use the best available evidence now, but rather wishes to wait for definitive evidence they are risking incurring large costs for health care systems and for the patients they serve. An explicit analysis of uncertain clinical outcomes is a useful adjunct to guide decision making where there is clinical ambiguity. This approach offers a valid alternative to the default of clinical inactivity when faced with uncertainty.