bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile phone messaging to promote uptake of HIV testing among migrant African communities in the UK
Authors: Evans Catrin , Suggs L Suzanne , Turner Katie , Occa Aurora , Juma Amdani , Blake Holly 
Published: July 2018

Background: In the UK, African communities are a focus of public health efforts to increase uptake of HIV testing. Mobile phone interventions may be an innovative way of reaching migrant groups who are known to face multiple obstacles in accessing mainstream health services. This paper presents findings from a feasibility study that used participatory approaches to investigate the use of a text messaging intervention to encourage HIV testing among migrant African communities. Methods: Participants were recruited in the city of Nottingham by a team of community researchers. They were sent two text messages per week (one on HIV and one on general health) for 12 weeks. Baseline and follow-up questionnaires were completed to measure HIV testing behaviour, HIV-related knowledge and attitudes and general health. Participants’ views on the intervention were solicited. Results: One hundred and sixty-nine participants were enrolled in the study. Follow-up data on HIV testing were obtained for 76 participants (45%) and complete follow-up measures were available from 60 participants (36%). Eight reported seeking an HIV test during the study period. There were statistically significant positive changes in attitudes about HIV and a trend towards increased knowledge about HIV. One-third of participants reported improvements in physical activity levels, diet and stress management following the intervention. The intervention messages and structure were positively evaluated. Conclusion: Well-designed mobile phone messaging proved to be a feasible and acceptable intervention to promote both HIV testing and lifestyle behaviours among African migrant communities in the UK. When co-constructed with communities, they hold considerable promise for overcoming some of the health-related barriers faced by migrant populations in new countries. Future research and service development should focus on exploiting and evaluating this potential in relation to other key health priorities.
Double Down or Switch It Up: Should Low-Income Children Stay in Head Start for 2 Years or Switch Programs?
Authors: Jenkins Jade Marcus , Sabol Terri J. , Farkas George 
Published: July 2018

Background: Recent growth in subsidized preschool opportunities in the United States for low-income 4-year-old children has allowed federal Head Start programs to fund more slots for 3-year-old children. In turn, when Age-3 Head Start participants turn four, they may choose to switch into one of the many alternative care options or choose to stay in Head Start for a second year. Objectives: We analyze a nationally representative sample of Age-3 Head Start participants to examine whether children who stay in Head Start for a second year at Age 4 exhibit greater school readiness and subsequent cognitive and behavioral performance compared with children who switch out of Head Start into alternative care. We also examine differences between children who stay at the same Head Start center at Age 4 with those who switch to a different Head Start center. Research Design: Child fixed effects analyses coupled with inverse probability of treatment weights to remove observable, time-invariant differences between Head Start stayers and switchers. Subjects: Cohort of Age-3 Head Start attendees from the Head Start Impact Study. Measures: Child cognitive and behavioral skills assessed by trained administrators annually at ages 3–7. Results: Age-3 Head Start participants’ outcomes do not differ at the end of preschool, kindergarten, or first grade based on their choice of Age-4 program. Staying at the same Head Start center for 2 years may be beneficial for behavioral skills. Conclusions: For low-income families, there exist many equally beneficial options to support their children’s school readiness through public preschool programs.
Prescribing practices of veterinarians in the treatment of chronic musculoskeletal pain in cats
Authors: Adrian Derek E , Rishniw Mark , Scherk Margie , Lascelles B Duncan X 
Published: July 2018

Objectives Despite the high prevalence and increasing awareness of chronic musculoskeletal pain in cats, approved treatment options are completely lacking in the USA, and few other options have sufficient safety and efficacy data. Knowledge of current prescribing practices should inform future research of putative therapies. We aimed to determine which drug and non-drug therapies were being used by general practitioners for the treatment of musculoskeletal pain in cats and to understand demographic influences on prescribing practices. Methods We distributed a survey to 36,676 veterinarians who were members of the Veterinary Information Network in January 2017. Within 3 weeks, 1056 practitioners completed the survey. The survey included demographic and background information, questions on prescribing frequency and dosing regimen of 13 drug and non-drug therapies and questions on preferred medication formulations and dosing frequencies. Descriptive statistics were used, as well as χ2 testing to evaluate relationships between demographic variables and prescription practices. Results Gabapentin was prescribed most frequently (71% of respondents), followed by joint supplements (67.8%), meloxicam (64.0%), opioids (62.6%), fish oil (62.1%) and polysulfated glycosaminoglycans (61.9%). Years in practice appeared to influence prescribing habits, with practitioners graduated for >20 years prescribing glucocorticoids more frequently than other age groups ( P = 0.0002), whereas recent graduates (<1 year) reported prescribing therapies less frequently across all categories. Conclusions and relevance These results show a contrast between therapies prescribed by practitioners and what is supported by evidenced-based literature. Future research evaluating the safety and efficacy of gabapentin should be prioritised.
A meta-ethnographic review of interprofessional teamwork in hospitals: what it is and why it doesn’t happen more often
Authors: Petit dit Dariel Odessa , Cristofalo Paula 
Published: July 2018

Objectives Although interprofessional teamwork has been shown to improve patient safety, it is not yet routine practice in most hospital settings. There is also a lack of clarity regarding what teamwork actually means, with terms such as collaboration, coordination, networking and knotworking often being used interchangeably. In this study, we analyse 20 years of qualitative research on interprofessional teamwork in hospital settings and examine what it looks like and the factors influencing it. Methods The literature search included articles published between 1996 and 2016, and articles were included if they examined interprofessional teamwork within a hospital using qualitative methodology. We used meta-ethnographic analysis of eligible primary studies applying reciprocal translation and line of argument synthesis. Results Nineteen articles were included. Interprofessional teamwork was largely absent in acute care and found to be influenced by systems perpetuating power imbalances, organizational practices that interfered with interprofessional interactions, representations of teamwork and leadership. Conclusions Future strategies to improve interprofessional practices should include policies and structural changes to develop healthcare systems that facilitate these practices.
Diabetes self-care management practices among insulin-taking patients
Authors: Gharaibeh Besher , Tawalbeh Loai Issa 
Published: July 2018

Background Diabetes self-care management (DSCM) is complex because various factors and relationships influence its processes. Aims This study aimed to identify the level of DSCM, compare the levels of self care between patients with type 1 and patients with type 2 diabetes, and identify significant predictors of self-care among Jordanian patients with type 1 and type 2 diabetes who were taking insulin. Methods A descriptive cross-sectional design was employed using a convenience sample of 310 Jordanian patients. The Arabic translated version of the 40-item Diabetes Self-Management Scale was used to collect data. Results The type of diabetes ( t(310) = 4.81; p < .001) and the type of medications (insulin, or insulin and tablets) ( t(310) = 4.75; p < .001) significantly affected the level of self-care. Age ( t(296) = − 3.41; p = 0.001), gender ( t(296) = −4.78; p < 0.001) training in self-care ( t(296) = 4.30; p < .001), educational level ( t(296) = 2.81, P = .005) and using traditional treatment (herbal therapy) ( t(296) = −4.64, p < .001) significantly predicted self-care and explained around 58% of the variance in self-care. Conclusions Various factors were found to influence self-care. Further research is needed to explore the complex nature of DSCM.
The meaning of coping for kidney transplant recipients: a phenomenological study
Authors: Valizadeh Zare Najmeh , Mohammadi Eesa , Zarea Kourosh , Elahi Nasrin , Manzari Zahra 
Published: July 2018

Background The meaning of coping, which can be affected by the nature and type of stress and by individuals’ background and culture, has not been studied in the context of specific stress conditions, such as kidney transplant. Aims The present study aims to explore the meaning of coping for kidney transplant recipients. Methods Purposeful sampling was employed for this hermeneutic phenomenological study. Participants were nine kidney transplant recipients who had received treatment at specialised hospital centres in Mashhad and Ahwaz, Iran, in 2013. Data were collected from unstructured interviews and analysed using Van Manen’s approach. Results From 10 sub-themes emerged 4 major themes characterising the meaning of coping with renal transplantation: intelligent acceptance of changes, understanding the necessity of self-care, enduring, and understanding supportive encouragement. Conclusions The meaning of coping for kidney transplant recipients in Iran encompasses a wide range of cognitive, behavioural, psychological, spiritual and social dimensions. Relying on God’s eternal power and on imams emerged as major dimensions of the meaning of coping.
Impact of Body Mass Index on Perioperative Outcomes of Endoscopic Pituitary Surgery
Authors: Lee Yung-Jae , Wong Anni , Filimonov Andrey , Sangal Neel R. , Yeon Chung Sei , Hsueh Wayne D. , Baredes Soly , Eloy Jean Anderson 
Published: July 2018

Background Endoscopic pituitary surgery (EPS) is increasingly being used for the treatment of pituitary lesions. Obesity is a growing epidemic in our nation associated with numerous comorbidities known to impact surgical outcomes. We present a multi-institutional database study evaluating the association between body mass index (BMI) and postsurgical outcomes of EPS. Methods Patients who underwent EPS from 2005 to 2013 were identified from the American College of Surgeons National Surgical Quality Improvement Program database. Preoperative variables, comorbidities, and postoperative outcomes, such as 30-day complications, morbidity, and mortality, were analyzed. Results A total of 789 patients were analyzed, of which 382 were obese (BMI ≥ 30) (48.4%). No difference in reoperation rate ( P = .928) or unplanned readmission rates ( P = .837) was found between the obese versus nonobese group. A higher overall complication rate was observed in the obese group compared to the nonobese counterparts ( P = .005). However, when separated into surgical complications (3.7% vs 1.5%, P = .068) and medical complications (7.6% vs 3.9%, P = .027), only medical complications, specifically pneumonia, remained significantly different. EPS on obese patients was also associated with prolonged operating time (154.8 min vs 141.0 min, P = .011). Conclusions EPS may be a safe treatment option for pituitary lesions in the obese population. Although obese patients undergoing EPS are at increased risk of medical complications and prolonged operating times, this did not influence mortality, reoperation, or readmission rate.
Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State
Authors: King John D. , Rowland Grant , Villasante Tezanos Alejandro G. , Warwick James , Kraus Virginia B. , Lattermann Christian , Jacobs Cale A. 
Published: July 2018

Objective The purpose of this study was to evaluate changes in the synovial fluid proteome following acute anterior cruciate ligament (ACL) injury. Design This study represents a secondary analysis of synovial fluid samples collected from the placebo group of a previous randomized trial. Arthrocentesis was performed twice on 6 patients with an isolated acute ACL tear at a mean of 6 and 14 days postinjury. Synovial fluid was analyzed by a highly multiplexed assay of 1129 proteins (SOMAscan version 3, SomaLogic, Inc., Boulder, CO). Pathway analysis using DAVID was performed; genes included met 3 criteria: significant change between the 2 study time points using a paired t test, significant change between the 2 study time points using a Mann-Whitney nonparametric test, and significant Benjamini post hoc analysis. Results Fifteen analytes demonstrated significant increases between time points. Five of the 15 have been previously associated with the onset and/or severity of rheumatoid arthritis, including apoliopoprotein E and isoform E3, vascular cell adhesion protein 1, interleukin-34, and cell surface glycoprotein CD200 receptor 1. Chondrodegenerative enzymes and products of cartilage degeneration all increased over time following injury: MMP-1 ( P = 0.08, standardized response mean [SRM] = 1.00), MMP-3 ( P = 0.05, SRM = 0.90), ADAM12 ( P = 0.03, SRM = 1.31), aggrecan ( P = 0.08, SRM = 1.13), and CTX-II ( P = 0.07, SRM = 0.56). Notable pathways that were differentially expressed following injury were the cytokine-cytokine receptor interaction and osteoclast differentiation pathways. Conclusions The proteomic results and pathway analysis demonstrated a pattern of cartilage degeneration, not only consistent with previous findings but also changes consistent with an inflammatory arthritogenic process post-ACL injury.
More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review
Authors: Hosking Diane E. , Ayton Scott , Beckett Nigel , Booth Andrew , Peters Ruth 
Published: July 2018

Background: Our aim was to systematically review the relationship between iron and incident cognitive decline or dementia from midlife onwards. Methods: Systematic review of eligible studies using Medline, Embase and PsycINFO® for the period from 1 January 1986 to 2 December 2016 (CRD42016023800), where study populations had a mean age of over 50 years and were free of cognitive impairment or dementia at baseline. Two authors independently extracted data according to eligibility criteria and assessed study characteristics, quality and outcomes. Disagreement was resolved by discussion. Results: A total of 1185 relevant records were identified with 12 full-text articles eligible for review. Six studies were excluded, leaving six texts to be included. Sample size ranged from 90 to 7173, with an average follow up of approximately 11.5 years. Baseline iron measures included brain iron ( n = 2), iron-related biomarkers in blood and plasma ( n = 2), and iron intake estimates from dietary records ( n = 2). Outcomes were dementia incidence ( n = 2) and longitudinal outcomes on neuropsychological tests ( n = 4). Bias was evident across studies in one or more of the following: recruitment, iron exposure, outcome assessments, potential confounders, missing data or attrition. Conclusions: Diversity across the small number of identified studies precludes conclusions regarding the role of iron in cognitive decline or dementia. Our review highlights substantial gaps in the evidence base and the need for more comprehensive, higher quality studies in this area.
Reliability of functional outcome measures in adults with neurofibromatosis 1
Authors: Mullin Rebecca L , Golding John F , Smith Rebecca , Williams Victoria , Thomas Mary , Ferner Rosalie E 
Published: July 2018

Objectives: To determine intra-rater and inter-rater reliability of functional outcome measures in adults with neurofibromatosis 1 and to ascertain how closely objective and subjective measures align. Methods: A total of 49 ambulant adults with neurofibromatosis 1 aged 16 years and over were included in this observational study: median age 31 years (range: 16–66 years), 29 females, 20 males. Participants were video-recorded or photographed performing four functional outcome measures. Four raters from the neurofibromatosis centre multi-disciplinary team independently scored the measures to determine inter-rater reliability. One rater scored the measures a second time on a separate occasion to determine intra-rater reliability. The measures evaluated were the functional reach, timed up and go, 10 m walk and a modified nine-hole peg tests. Participants also completed a disease-specific quality-of-life questionnaire. Results: Inter-rater reliability and intra-rater reliability scores (intra-class coefficient) were similar for each outcome measure. Excellent rater agreement (intra-class coefficient, r ⩾ 0.9) was found for the functional reach, timed up and go and the 10 m walk tests. Rater agreement was good for the modified nine-hole peg test: intra-class coefficient r = 0.75 for intra-rater reliability and 0.76 for inter-rater reliability. The timed up and go and the 10 m walk tests correlated highly with perceived mobility challenges in the quality-of-life questionnaire. Conclusion: The functional reach, timed up and go and 10 m walk tests are potentially useful outcome measures for monitoring neurofibromatosis 1 treatment and will be assessed in multi-centre and longitudinal studies.
Epidemiological Patterns of Alternative Racquet-Sport Injuries in the United States, 1997-2016
Authors: Nhan Derek T. , Klyce Walter , Lee R. Jay 
Published: July 2018

Background: Racquet sports have increased in popularity over the past decade. Although research is available regarding the epidemiological characteristics of tennis injuries, little is known about the frequency and characteristics of injuries in other racquet sports. Hypothesis: Given the increase in all racquet sport participation in the United States (US), it is hypothesized that injuries have accordingly become more frequent. Study Design: Descriptive epidemiology study. Methods: Using the National Electronic Injury Surveillance System database, we reviewed the numbers of badminton and squash/racquetball injuries presenting to a representative sample of US emergency departments (EDs). We used weighted estimates to extrapolate the data to the US population. Incidence estimates were compared with national participation data and stratified. Results: A total of 4330 injuries were reported, representing an estimated 173,000 injuries presenting to US EDs from 1997 through 2016. Despite the increase in the number of players from 2006 through 2016, the annual injury rate for squash/racquetball declined significantly, including the rates for each body region assessed. No similar trend was found for badminton injuries. Within our extrapolated ED cohort, the lower extremities were the most common body region injured (37%). Strains/sprains were the most common injury type in the trunk (73%), lower extremities (65%), and upper extremities (32%), whereas lacerations were most common in the head/neck (49%). In badminton, the youngest players (age range, 5-18 years) sustained twice as many fractures (relative risk [RR], 1.96; 95% CI, 1.14-3.38) and almost 3 times as many lacerations as patients in any other age group. Similarly, the youngest squash/racquetball players were at highest risk for lacerations (RR, 1.45; 95% CI, 1.22-1.73) and head and neck injuries (RR, 1.52; 95% CI, 1.26-1.83). Conclusion: Although declines in rates of squash/racquetball injuries were observed, the increasing popularity of badminton, squash, and racquetball necessitates further preventive measures to improve player safety, with an emphasis on the youngest players.
Perception of Factors Influencing Primary Health-Care Facility Choice Among National Health Insurance Enrollees of a Northwest Nigerian Hospital
Authors: Michael Godpower Chinedu , Aliyu Ibrahim , Grema Bukar Alhaji , Suleiman Abdullahi Kabiru 
Published: July 2018

Background: The National Health Insurance Scheme (NHIS) of Nigeria was designed to eliminate known cultural, physical, and resource-related barriers to quality health-care access. Although choice of primary health-care facility (PHF) remains in the domain of the scheme enrollees, little is known about factors influencing their choice. Hence, the study of the perception of factors influencing PHF choice among NHIS enrollees of a northwest Nigerian hospital becomes imperative. Methods: This was a cross-sectional study of 284 principal enrollees randomly selected from patients attending the NHIS clinic of Aminu Kano Teaching Hospital, Kano, Nigeria, using a designed, pretested, investigator-administered questionnaire. Their sociodemographics and factors influencing their choice of the clinic were assessed. Results: Respondents’ mean age was 40.9 ± 9.0 years and they were predominantly males (83.1%) with tertiary education. Median distance between their homes and PHF was 7.6 ± 12.5 km. Most respondents were aware of other accredited PHFs in the city and believed it was their right to choose a PHF. Among the various factors influencing their choice of index PHF were better functioning equipment (83.5% of respondents), more specialists/trained health workers (78.5%), ease in receiving specialist care (69.4%), and better overall quality of care (78.9%). Conclusion: There are multiple factors associated with enrollee choice of PHF in this study. The NHIS enrollees value the presence of functioning equipment/facilities, ease in receiving specialist care, and overall high quality of care in their choice of PHF. Improving enrollee enrollment at accredited PHF may require addressing these factors.
CLT030, a leukemic stem cell–targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia
Authors: Jiang Ying-Ping , Liu Bob Y. , Zheng Quan , Panuganti Swapna , Chen Ruoying , Zhu Jianyu , Mishra Madhavi , Huang Jianqing , Dao-Pick Trang , Roy Sharmili , Zhao XiaoXian , Lin Jeffrey , Banik Gautam , Hsi Eric D. , Mandalam Ramkumar , Junutula Jagath R. 
Published: July 2018

Key Points
CLL1-ADC targets both AML blasts and LSCs. Unlike CD33-ADC, CLL1-ADC does not affect normal HSCs.
THE MESOZOIC EXTENDED SPONGES - COLONIES WITHIN THE METAMORPHIC PLATTENKALK GROUP OF THE EXTERNAL HELLENIDES
Authors: Μανούτσογλου Ε. 
Published: July 2018

In the present work the spatiotemporal distribution of relics from extended colonies of sponges that were located and preserved within metamorphic rocks of the Plattenkalk Group of the External Hellenides is presented and discussed. Based on reports regarding extensive occurence of sponges during Upper Jurassic in Europe, published and new data for the occurence of probable Demospongiae in mainly mountainous regions of Southern Péloponnèse and Crete are compiled. This data allow a better palaeoecological approach and a probable partial revision of the evolution of the palaeogeographical deposition area of an important part of the External Hellenides.
Tourette syndrome research highlights from 2017
Authors: Hartmann Andreas , Worbe Yulia , Black Kevin J. 
Published: July 2018

This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The highlights from 2018 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. After the calendar year ends, the article is submitted as the annual update for the Tics collection on F1000Research.