bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Dietary Carbohydrate Type on Serum Cardiometabolic Risk Indicators and Adipose Tissue Inflammatory Markers
Authors: Meng Huicui , Matthan Nirupa R , Fried Susan K , Berciano Silvia , Walker Maura E , Galluccio Jean M , Lichtenstein Alice H 
Published: June 2018

Abstract

Context and Objective
Direct comparisons between types of dietary carbohydrate in terms of cardiometabolic risk indicators are limited. This study was designed to compare the effects of an isocaloric exchange of simple, refined, and unrefined carbohydrates on serum cardiometabolic risk indicators, adipose tissue inflammatory markers, and peripheral blood mononuclear cell (PBMC) fractional cholesterol efflux.

Design, Participants, and Measures
Participants [postmenopausal women and men (N = 11), 65 ± 8 years, body mass index 29.8 ± 3.2 kg/m2, low-density lipoprotein (LDL) cholesterol ≥2.6 mmol/L] were provided with diets (60% energy from total carbohydrate, 15% from protein, 25% from fat) for 4.5 weeks in a randomized crossover design, with 2-week washout periods. The variable component was an isocaloric exchange of simple, refined, or unrefined carbohydrate–containing foods. Serum lipoprotein, glucose, insulin, and inflammatory marker concentrations were measured. Abdominal subcutaneous adipose tissue was aspirated to assess macrophage and inflammatory marker gene expression and ex vivo cytokine secretion, and PBMCs were isolated to assess ex vivo fractional cholesterol efflux.

Results
Fasting serum LDL and non–high-density lipoprotein (HDL) cholesterol concentrations were higher after the refined compared with simple or unrefined carbohydrate–enriched diets (P &lt; 0.01). Other serum measures, ex vivo fractional cholesterol efflux and adipose tissue gene expression and ex vivo cytokine secretion, were similar between diets.

Conclusions
Diets enriched in refined compared with simple or unrefined carbohydrate resulted in higher fasting serum LDL and non-HDL cholesterol concentrations but had little effect on other cardiometabolic risk indicators. This small study raises the intriguing possibility that refined carbohydrate may have unique adverse effects on cardiometabolic risk indicators distinct from simple and unrefined carbohydrate.
Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?
Authors: Stanczyk Paulina J. , Seidel Monika , White Judith , Viero Cedric , George Christopher H. , Zissimopoulos Spyros , Lai F. Anthony 
Published: June 2018

ABSTRACT
The cardiac muscle ryanodine receptor-Ca2+ release channel (RyR2) constitutes the sarcoplasmic reticulum (SR) Ca2+ efflux mechanism that initiates myocyte contraction, while cardiac myosin-binding protein-C (cMyBP-C; also known as MYBPC3) mediates regulation of acto-myosin cross-bridge cycling. In this paper, we provide the first evidence for the presence of direct interaction between these two proteins, forming a RyR2–cMyBP-C complex. The C-terminus of cMyBP-C binds with the RyR2 N-terminus in mammalian cells and the interaction is not mediated by a fibronectin-like domain. Notably, we detected complex formation between both recombinant cMyBP-C and RyR2, as well as between the native proteins in cardiac tissue. Cellular Ca2+ dynamics in HEK293 cells is altered upon co-expression of cMyBP-C and RyR2, with lowered frequency of RyR2-mediated spontaneous Ca2+ oscillations, suggesting that cMyBP-C exerts a potential inhibitory effect on RyR2-dependent Ca2+ release. Discovery of a functional RyR2 association with cMyBP-C provides direct evidence for a putative mechanistic link between cytosolic soluble cMyBP-C and SR-mediated Ca2+ release, via RyR2. Importantly, this interaction may have clinical relevance to the observed cMyBP-C and RyR2 dysfunction in cardiac pathologies, such as hypertrophic cardiomyopathy.
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology
Authors: Gonias Steven L. , Banki Michael A. , Gilder Andrew S. , Azmoon Pardis , Campana Wendy M. , Mantuano Elisabetta 
Published: June 2018

ABSTRACT
The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling. Plasminogen activator inhibitor-1 (PAI1, also known as SERPINE1) is a rapidly acting inhibitor of tPA enzyme activity. Although tPA-initiated cell signaling is not dependent on its enzyme active site, we show that tPA signaling is neutralized by PAI1. In PC12 cells, PAI1 blocked the ERK1/2 activation mediated by tPA as well as neurite outgrowth. In Schwann cells, PAI1 blocked tPA-mediated ERK1/2 activation and cell migration. In macrophages, PAI1 blocked the ability of tPA to inhibit IκBα phosphorylation and cytokine expression. The cell signaling activity of tPA–PAI1 complex was rescued when the complex was formed with PAI1R76E, which binds to LRP1 with decreased affinity, by pre-treating cells with the LRP1 antagonist receptor-associated protein and upon LRP1 gene silencing. The inhibitory role of LRP1 in tPA–PAI1 complex-initiated cell signaling was unanticipated given the reported role of LRP1 as an NMDA-R co-receptor in signaling responses elicited by free tPA or α2-macroglobulin. We conclude that PAI1 functions as an in­hibitor not only of the enzyme activity of tPA but also of tPA receptor-mediated activities.
The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa
Authors: Mboowa Gerald , Mwesigwa Savannah , Katagirya Eric , Retshabile Gaone , Mlotshwa Busisiwe C. , Williams Lesedi , Kekitiinwa Adeodata , Kateete David , Wampande Eddie , Wayengera Misaki , Kintu Betty Nsangi , Kisitu Grace P. , Kyobe Samuel , Brown Chester W. , Hanchard Neil A. , Mardon Graeme , Joloba Moses , Anabwani Gabriel , Pettitt Ed , Tsimako-Johnstone Masego , Kasvosve Ishmael , Maplanka Koketso , Mpoloka Sununguko W. , Hlatshwayo Makhosazana , Matshaba Mogomotsi 
Published: June 2018

Background: Here, we describe how the Collaborative African Genomics Network (CAfGEN) of the Human Heredity and Health in Africa (H3Africa) consortium is using genomics to probe host genetic factors important to the progression of HIV and HIV-tuberculosis (TB) coinfection in sub-Saharan Africa. The H3Africa was conceived to facilitate the application of genomics technologies to improve health across Africa.. Methods: CAfGEN is an H3Africa collaborative centre comprising expertise from the University of Botswana; Makerere University; Baylor College of Medicine Children’s Clinical Centers of Excellence (COEs) in Botswana, Uganda, and Swaziland; as well as Baylor College of Medicine, Texas. The COEs provide clinical expertise for community engagement, participant recruitment and sample collection while the three University settings facilitate processing and management of genomic samples and provide infrastructure and training opportunities to sustain genomics research. Results: The project has focused on utilizing whole-exome sequencing to identify genetic variants contributing to extreme HIV disease progression phenotypes in children, as well as RNA sequencing and integrated genomics to identify host genetic factors associated with TB disease progression among HIV-positive children. These cohorts, developed using the COEs’ electronic medical records, are exceptionally well-phenotyped and present an unprecedented opportunity to assess genetic factors in individuals whose HIV was acquired by a different route than their adult counterparts in the context of a unique clinical course and disease pathophysiology. Conclusions: Our approach offers the prospect of developing a critical mass of well-trained, highly-skilled, continent-based African genomic scientists. To ensure long term genomics research sustainability in Africa, CAfGEN contributes to a wide range of genomics capacity and infrastructure development on the continent, has laid a foundation for genomics graduate programs at its institutions, and continues to actively promote genomics research through innovative forms of community engagement brokered by partnerships with governments and academia to support genomics policy formulation.
Copycat Layout: Network layout alignment via Cytoscape Automation
Authors: Settle Brett , Otasek David , Morris John H , Demchak Barry 
Published: June 2018

The copycatLayout app is a network-based visual differential analysis tool that improves upon the existing layoutSaver app and is delivered pre-installed with Cytoscape, beginning with v3.6.0. LayoutSaver cloned a network layout by mapping node locations from one network to another based on node attribute values, but failed to clone view scale and location, and provided no means of identifying which nodes were successfully mapped between networks. Copycat addresses these issues and provides additional layout options. With the advent of Cytoscape Automation (packaged in Cytoscape v3.6.0), researchers can utilize the Copycat layout and its output in workflows written in their language of choice by using only a few simple REST calls. Copycat enables researchers to visually compare groups of homologous genes, generate network comparison images for publications, and quickly identify differences between similar networks at a glance without leaving their script. With a few extra REST calls, scripts can discover nodes present in one network but not in the other, which can feed into more complex analyses (e.g., modifying mismatched nodes based on new data, then re-running the layout to highlight additional network changes).
Síndrome de Burnout: Estudo com Professores da Rede Pública da Cidade de Farroupilha no Rio Grande do Sul
Authors: Moreira Danielle Lima , Brito Lucas Charão , Obregon Sandra Leonara , Tolfo Ribas Fábio Teodoro , Dias Lopes Luis Felipe 
Published: June 2018

A síndrome de burnoutcostuma ser identificada em profissionais que trabalham diretamente com outras pessoas, como é o caso dos professores. Sendo assim, o estudo tem por objetivo analisar as dimensões da síndrome de burnoutem professores da rede pública de ensino da cidade de Farroupilha, no estado do Rio Grande do Sul. A amostra foi composta por 262 professores atuantes em 28 escolas municipais de Farroupilha, sendo que metodologicamente o estudo classifica-se por ter abordagem quantitativa, de natureza descritiva, utilizando para a coleta de dados o instrumento Maslach Burnout Inventory (MBI) na forma Educators Survey (ES), MBI-ES, criado exclusivamente para a identificação da síndrome em professores. Os resultados evidenciam baixo nível de exaustão e despersonalização, e alto nível de realização profissional nos professores, ou seja, não foram percebidos sinais da síndrome de burnoutna amostra pesquisada.
Formação Docente em Administração: Um Estudo Bibliométrico
Authors: Maranhão Carolina Machado Saraiva de Albuquerque , Maranhão Roberto Kaehler de Albuquerque , Ferreira Rafael Fernandes , Fernandes Talita Almeida , Dutra Isadora Iannini Cota 
Published: June 2018

No Brasil, existe uma carência de políticas de formação dos professores do curso de Administração, por parte do governo e das organizações de ensino superior em Administração. O propósito central do trabalho é investigar o que se pesquisa no campo de formação de professores de Administração no Brasil. Segundo o Censo de Educação Superior de 2015, o curso de Administração encontra-se entre os cursos com maior número de estudantes do país. Dessa forma, o presente trabalho se justifica apresentando como se organiza e desenvolve os estudos sobre formação de professor. Um levantamento quantitativo e uma análise bibliométrica sobre formação docente foram feitos nos principais congressos e revistas de Administração nos últimos 14 anos. Através desses dados, realizou-se uma análise sobre os avanços e descobertas feitas até o momento, bem como apresentaram-se as principais conclusões obtidas sobre o tema. Observa-se a pouca discussão e estudo sobre formação docente em Administração.
Beyond the in-between: Rei Kawakubo at The Met and the clash between eastern and western concepts in fashion studies
Authors: von Busch Otto 
Published: June 2018

Abstract
The 2017 exhibition Rei Kawakubo/Comme des Garçons – Art of the In-Between at the Metropolitan Museum in New York exposed the rich work of the iconic Japanese fashion designer Rei Kawakubo to a larger western audience. As the title of the exhibition indicates, Kawakubo’s work does not fit well within some of the classic conceptual assumptions around fashion, but can be placed as something ‘in-between’. The show and printed museum guide were arranged around a series of conceptual dichotomies that Kawakubo’s work transgressed. Yet these transgressions also exposed the arbitrariness of central distinctions in fashion and questioned how universal key concepts in fashion really are. In examining the printed guide to the Kawakubo show, this text challenges the intercultural applicability of concepts such as ‘fetish’ and ‘copy’ across cultural spheres in fashion studies, and questions the universal application of such concepts to unpack meanings and practices in fashion.
Exploring the boundaries between theory and practice in Fashion Design at IUAV University of Venice: The case of U/U/U/
Authors: Monti Gabriele , Sargentini Mariavittoria 
Published: June 2018

Abstract
Still today, in Italy, fashion design finds it difficult to relate to the dimension of university research, and this is perhaps the consequence of a lack of familiarity with the academic world: only rarely has fashion been taught in universities and it is not considered an autonomous academic discipline. Since its foundation in 2005, the BA programme in Fashion Design at IUAV University of Venice has been actively combining its design workshops with an attitude towards research in the field of fashion studies, with innovative work being carried out specifically in the field of teaching methodologies: students are asked to constantly question and discuss teaching practices and techniques – which tend to be taken for granted – as well as the concept of authorship in design. This approach – quite unique in the Italian academic field – is presented in this article through a discussion of a project originated by designer Mariavittoria Sargentini, founder and owner of the brand Marvielab, and course leader of the first-year Fashion Design Workshop at IUAV. Together with her students, Sargentini started a new collection called U/U/U/, which stands for ‘unconstrained, unisex, uniform’, after asking a group of students to redefine the concept of the daily uniform through their own interpretations. The result is a capsule collection, made of twelve looks, as the expression of a collective author. Thus, Sargentini’s U/U/U/ reflects an idea of fashion design that defies current concepts of authorship, and that questions our concept of the basic/daily uniform through an active design practice that fuses theory and object-based observations.
Comparative book review: On thinking through and researching fashion today
Authors: Bide Bethan 
Published: June 2018

Abstract
Fashion Studies: Research Methods, Sites and Practices, Heike Jenss (ed.) (2016) London: Bloomsbury, 248 pp., ISBN 9781472583161, Paperback, £21.99 ISBN 9781472583178, 256 pp., Hardback, £85.00 ISBN 9781472583192, EPUB/MOBI e-book, £21.99
Thinking Through Fashion: A Guide to Key Theorists, AgnÈs Rocamora and Anneke Smelik (eds) (2016) London: I.B. Tauris, 320 pp, ISBN 9781780767345, Paperback, £16.99 ISBN 9781780767338, Hardback, £69.99
Farmakološka in nefarmakološka terapija za zdravljenje primarne dismenoreje
Authors: Kavšak Aleksandra , Avdylaj Liridon 
Published: June 2018

Uvod: V prispevku smo na podlagi sistematičnega pregleda literature identificirali različne oblike farmakološkega in nefarmakološkega zdravljenja, ki lahko ženskam s primarno dismenorejo pomagajo zmanjšati intenziteto bolečine. Namen raziskave je bil namreč ugotoviti oblike farmakološke in nefarmakološke terapije za zmanjšanje bolečine pri primarni dismenoreji.Metode: Za iskanje literature so bile uporabljene podatkovne baze: CINAHL, Medline, ScienceDirect in Cochrane Library. Uporabljeni so bili naslednji iskalni pojmi: primarna dismenoreja, menstrualna bolečina, farmakološko zdravljenje, nefarmakološko zdravljenje; v angleškem jeziku: primary dysmenorrhea, menstrual pain, pharmalogical intervention, non-pharmacological intervention. Iskanje je bilo omejeno na znanstvene revije, recenzirane publikacije, dostopne v celotnem besedilu, besedila, objavljena v angleškem jeziku v obdobju 2007–2017. Skupaj je bilo identificiranih 571 zadetkov, v končno analizo je bilo vključenih 13 raziskav, ki so ustrezale namenu raziskave.Rezultati: Analiziranih je bilo 13 raziskav, od tega pet farmakoloških in osem nefarmakoloških oblik zdravljenja. Rezultati raziskave so pokazali, da nesteroidna protivnetna zdravila ponujajo precejšnje zmanjšanje bolečine pri večini žensk s primarno dismenorejo. Ugotovitve kažejo, da vse oblike nefarmakološkega zdravljenja niso priporočljive in pri pacientkah s primarno dismenorejo ne pomagajo zmanjšati intenzitete bolečine. Diskusija in zaključek: Rezultati sistematičnega pregleda literature kažejo, da farmakološko zdravljenje učinkoviteje zmanjšuje intenziteto bolečine, saj se učinek delovanja zdravila izkaže v eni uri po zaužitju, vendar povzroča nekatere stranske učinke.
The schizophrenia coping oral health profile. Development and feasibility
Authors: Siu-Paredes Francesca , Rude Nathalie , Rat Corinne , Reynaud Matthieu , Hamad Mohamad , Moussa-Badran Sahar , Denis Frederic 
Published: June 2018

Abstract

Background
The aim of this work was to present the creation of appropriate tools to evaluate the coping strategies in Oral-Health-related Quality of Life (OHrQOL) implemented by persons with schizophrenia (PWS), the Schizophrenia Coping Oral Health Profile (SCOOHP), and the results of a feasibility study.

Methods
A qualitative investigation was conducted between June 2016 and May 2017.
The first step included 26 semi-structured individual interviews, 20 with PWS and 6 with health professionals (HPs), and 2 focus groups (PWS and HPs) to explore the experiences of the participants and how they felt about coping strategies in OHrQOL. The second step was a feasibility study involving a statistical analysis to test the acceptability and internal consistency (Cronbach’s α) of the SCOOHP.

Results
The analysis of these interviews allowed for us to obtain 277 items from 3545 verbatim transcriptions related to various dimensions of OHrQOL. We presented the items selected in coping concepts in this study. After selecting items in several stages, we drew up the SCOOHP scale with 23 items (15 items for positive coping and 8 items for negative coping). The feasibility study showed good acceptability, good understanding of the items and good consistency reliability (α = 0.59).

Conclusions
This is the first study that has enabled us to draw up a specific tool to assess coping strategies in OHrQOL of PWS. A multicentre study involving a larger sample of PWS is underway in order to perform the psychometric validation of the SCOOHP.

Trial registration
Clinical Trials Gov NCT02730832. Date registered: 21 March 2016.
Body Weight and Mood State Modifications in Mixed Martial Arts: An Exploratory Pilot
Authors: Brandt Ricardo , Bevilacqua Guilherme G. , Coimbra Danilo R. , Pombo Luiz C. , Miarka Bianca , Lane Andrew M. 
Published: June 2018

Abstract
Brandt, R, Bevilacqua, GG, Coimbra, DR, Pombo, LC, Miarka, B, and Lane, AM. Body weight and mood state modifications in mixed martial arts: An exploratory pilot. J Strength Cond Res 32(9): 2548–2554, 2018—Mixed martial arts (MMA) fighters typically use rapid weight loss (RWL) as a strategy to make competition weight. The aim of the present study was to compare body weight and mood changes in professional male MMA athletes who used strategies to rapidly lose weight (n = 9) and with MMA athletes who did not (n = 3). Body mass and mood states of anger, confusion, depression, fatigue, tension, and vigor and total mood disturbance were assessed (a) 30 days before competition, (b) at the official weigh-in 1 day before competition, (c) 10 minutes before competition, and (d) 10 minutes postcompetition. Results indicated that RWL associated with reporting higher confusion and greater total mood disturbance at each assessment point. Rapid weight loss also associated with high anger at the official weigh-in. However, in performance, RWL did not have deleterious effects on performance. The RWL group also reported greater total mood disturbance at all assessment points with a moderate difference effect size. Research supports the notion that RWL associates with potentially dysfunctional mood states.
Accentuated Eccentric Loading and Cluster Set Configurations in the Back Squat: A Kinetic and Kinematic Analysis
Authors: Wagle John P. , Cunanan Aaron J. , Carroll Kevin M. , Sams Matt L. , Wetmore Alexander , Bingham Garett E. , Taber Christopher B. , DeWeese Brad H. , Sato Kimitake , Stuart Charles A. , Stone Michael H. 
Published: June 2018

Abstract
Wagle, JP, Cunanan, AJ, Carroll, KM, Sams, ML, Wetmore, A, Bingham, GE, Taber, CB, DeWeese, BH, Sato, K, Stuart, CA, and Stone, MH. Accentuated eccentric loading and cluster set configurations in the back squat: a kinetic and kinematic analysis. J Strength Cond Res 35(2): 420–427, 2021—This study examined the kinetic and kinematic differences between accentuated eccentric loading (AEL) and cluster sets in trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, and back squat to body mass ratio = 1.8 ± 0.3). Four load condition sessions consisted of traditionally loaded (TL) “straight sets,” TL cluster (TLC) sets, AEL cluster (AEC) sets, and AEL “straight sets” where only the first repetition had eccentric overload (AEL1). An interrepetition rest interval of 30 seconds was prescribed for both TLC and AEC. Concentric intensity for all load conditions was 80% 1 repetition maximum (1RM). Accentuated eccentric loading was applied to repetitions using weight releasers with total eccentric load equivalent to 105% of concentric 1RM. Traditionally loaded cluster had statistically greater concentric outputs than TL. Furthermore, statistically greater eccentric and concentric outputs were observed during AEC compared with TL with the exception of peak power. Statistically greater concentric characteristics were observed in TLC compared with AEL1, but statistically greater eccentric outputs were observed in AEL1. In the 2 cluster set conditions, statistically greater concentric rate of force development (RFDCON) (d = 0.470, p < 0.001) and average velocity (vavg) (d = 0.560, p < 0.001) in TLC compared with AEC were observed. However, statistically greater eccentric work (WECC) (d = 2.096, p < 0.001) and eccentric RFD (RFDECC) (d = 0.424, p < 0.001) were observed in AEC compared with TLC. Overall, eccentric overload demonstrated efficacy as a means of increasing eccentric work and RFD, but not as a means of potentiating concentric output. Finally, interrepetition rest seems to have the largest influence on concentric power output and RFD.