bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of parental activation interventions for parents of children with special health care needs
Authors: Mirza M. , Krischer A. , Stolley M. , Magaña S. , Martin M. 
Published: February 2018

AbstractBackgroundA large number of U.S. children are identified as having special health care needs (CSHCN). Despite parents' central role in managing their child's needs, many parents report difficulties in navigating service systems, finding information about their child's condition, and accessing health care and community resources. Therefore, there is a need for interventions that “activate” parents of children with special health care needs to increase their knowledge, skills, and confidence in managing, coordinating, and advocating for their child's needs. This study sought to review the existing literature and examine the effects of parent support interventions that focus on parental activation either in part or whole, on child, parent, or family outcomes. Specific aims included (a) summarizing the nature and content of interventions; (b) describing changes in relevant outcomes; (c) identifying limitations and making recommendations for future research.MethodsFollowing electronic databases were searched: MEDLINE, EMBASE, PsycINFO via ProQuest, PubMed, Cumulative Index to Nursing and Allied Health via EBSCO, Education Resources Information Center (ERIC) via ProQuest, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), and Google Scholar. Twenty‐two studies were selected, data were extracted, and quality was assessed using standardized procedures.ResultsFive intervention categories were identified: parent‐to‐parent supports, psycho‐educational groups, content‐specific groups, community health worker model, and self‐management‐based interventions. Although most studies showed positive effects of the intervention, evidence was inconsistent for parental outcomes such as self‐efficacy, confidence, strain, depression, and perceived social support. Evidence was more consistent in showing improvement in parent coping and in use of community‐based services and resources.ConclusionsThere is a need to boost active ingredients of interventions that specifically target enhancing parent skill sets relevant to areas of self‐efficacy, confidence, and empowerment. Future studies must also adapt intervention and study design to recruit socioeconomically vulnerable families.
More Similar Than Different: Gender Differences in Children's Basic Numerical Skills Are the Exception Not the Rule
Authors: Hutchison Jane E. , Lyons Ian M. , Ansari Daniel 
Published: February 2018

This study investigates gender differences in basic numerical skills that are predictive of math achievement. Previous research in this area is inconsistent and has relied upon traditional hypothesis testing, which does not allow for assertive conclusions to be made regarding nonsignificant findings. This study is the first to compare male and female performance (N = 1,391; ages 6–13) on many basic numerical tasks using both Bayesian and frequentist analyses. The results provide strong evidence of gender similarities on the majority of basic numerical tasks measured, suggesting that a male advantage in foundational numerical skills is the exception rather than the rule.
Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma
Authors: Zhou Hengyu , Cai Ying , Liu Dina , Li Menghui , Sha Yu , Zhang Wenlu , Wang Kai , Gong Jianping , Tang Ni , Huang Ailong , Xia Jie 
Published: February 2018

AbstractObjectivesHistone deacetylases (HDACs) are commonly dysregulated in cancer and represent promising therapeutic targets. However, global HDAC inhibitors have shown limited efficacy in the treatment of solid tumours, including hepatocellular carcinoma (HCC). In this study, we investigated the therapeutic effect of selectively inhibiting HDAC1 and 2 in HCC.MethodsHDAC1 inhibitor Tacedinaline (CI994), HDAC2 inhibitor Santacruzamate A (CAY10683), HDAC1/2 common inhibitor Romidepsin (FK228) and global HDAC inhibitor Vorinostat (SAHA) were used to treat HCC cells. Cell cycle, apoptosis and the protein levels of CDKs and CDKNs were performed to evaluate HCC cell growth. Inhibition of HDAC1/2 by RNAi was further investigated.ResultsCombined inhibition of HDAC1/2 led to HCC cell morphology changes, growth inhibition, cell cycle blockage and apoptosis in vitro and suppressed the growth of subcutaneous HCC xenograft tumours in vivo. p21Waf1/Cip1 and p19INK4d, which play roles in cell cycle blockage and apoptosis induction, were upregulated. Inhibition of HDAC1/2 by siRNA further demonstrated that HDAC1 and 2 cooperate in blocking the cell cycle and inducing apoptosis via p19INK4d and p21Waf1/Cip1 upregulation. Finally, H3K18, H3K56 and H4K12 in the p19INK4d and p21Waf1/Cip1 promoter regions were found to be targets of HDAC1/2.ConclusionsPharmacological or transcriptional inhibition of HDAC1/2 increases p19INK4d and p21Waf1/Cip1 expression, decreases CDK expression and arrests HCC growth. These results indicated a potential pharmacological mechanism of selective HDAC1/2 inhibitors in HCC therapy.
Physical appearance concerns are uniquely associated with the severity of steroid dependence and depression in anabolic–androgenic steroid users
Authors: Griffiths Scott , Jacka Brendan , Degenhardt Louisa , Murray Stuart B. , Larance Briony 
Published: February 2018

AbstractIntroduction and AimsEmerging research suggests that the sub‐population of anabolic–androgenic steroid (AAS) users who experience physical appearance concerns may suffer greater psychological dysfunction than other sub‐populations, including users with athletic or occupational concerns. Thus, among current AAS users, we sought to determine whether, and to what extent, social physique anxiety—an established measure of appearance concern—was associated with psychological dysfunction.Design and MethodsInterviews were conducted with a sample of 74 male AAS users living in Australia. Users completed self‐report instruments of the severity of AAS dependence, depression, hazardous and risky drinking, use of non‐AAS illicit drugs, psychological side‐effects due to AAS use and abnormal test results due to AAS use.ResultsMultivariate analyses revealed that greater social physique anxiety was uniquely associated with more severe symptoms of both AAS dependence and depression. Moreover, the effect size of these relationships was large. Social physique anxiety was not associated with hazardous or risky drinking, non‐AAS illicit drug use, psychological side‐effects or abnormal test results.Discussion and ConclusionsLimitations notwithstanding, the study is consistent with the notion that AAS users who experience appearance concerns are at heightened risk of co‐morbid psychological dysfunction. Given trends indicating an increase in the prevalence of AAS use in Australia and elsewhere, the findings suggest that health‐care systems may need to consider prioritising the sub‐population of AAS users who experience appearance concerns. Further investigation of the clinical syndrome of AAS dependence is required, including its relation to body image and eating disorders.
Assessing habitat loss and fragmentation and their effects on population viability of forest specialist birds: Linking biogeographical and population approaches
Authors: Carvajal Mario A. , Alaniz Alberto J. , Smith‐Ramírez Cecilia , Sieving Kathryn E. 
Published: February 2018

AbstractAimBiogeographic approaches usually have been developed apart from population ecology, resulting in predictive models without key parameters needed to account for reproductive and behavioural limitations on dispersal. Our aim was to incorporate fully spatially explicit population traits into a classic species distribution model (SDM) using Geographic Information Systems (GIS), aiming at conservation purposes.LocationSouthern South America.MethodsOur analysis incorporates the effects of habitat loss and fragmentation on population viability and therefore provides insights into how much spatially explicit population traits can improve the SDM prediction of habitable habitat. We utilized a well‐studied focal endemic bird of South American temperate rainforests (Scelorchilus rubecula). First, at a large scale, we assessed the historical extent habitat based on climate envelopes in an SDM. Second, we used a land cover change analysis at a regional scale to account for recent habitat loss and fragmentation. Third, we used empirically derived criteria to predict population responses to fragmented forest landscapes to identify actual losses of habitat and population. Then we selected three sites of high conservation value in southern Chile and applied our population model. Finally, we discuss the degree to which spatially explicit population traits can improve the SDM output without intervening in the modelling process itself.ResultsWe found a historical habitat loss of 39.12% and an additional forest cover loss of 3.03% during 2000–2014; the latter occurred with a high degree of fragmentation, reducing the overall estimation of (1) carrying capacity by −82.4%, −33.1% and −45.1% and (2) estimated number of pairs on viable populations by −84.1%, −33.0% and −54.6% on the three selected sites.Main conclusionWe conclude that our approach sharpened the SDM prediction on environmental suitability by 54.4%, adjusting the habitable area by adding population parameters through GIS, and allowing to incorporate other phenomena as fragmentation and habitat loss.
“That is just what they want you to believe”: A modest defence of Marxist paranoia
Authors: Olsson Yaouzis Nicolas 
Published: February 2018

AbstractThis essay defends a rational reconstruction of a genealogical debunking argument that begins with the premise “that's just what the economic elite want you to believe” and ends in the conclusion “you should lower your confidence in your belief.” The argument is genealogical because it includes a causal explanation of your beliefs; it is debunking because it claims that the contingencies uncovered by the genealogy undermine your beliefs. The essay begins by defending a plausible causal explanation of your belief in terms of the wants of the elite. Then a number of recent objections to genealogical debunking arguments are considered. It is argued that the genealogy offered in the first part constitutes evidence that a testimony‐based belief is not safe and therefore does not constitute knowledge if the economic elite wants you to believe it.
Mutational analysis of TAF6 revealed the essential requirement of the histone‐fold domain and the HEAT repeat domain for transcriptional activation
Authors: Dahiya Rashmi , Natarajan Krishnamurthy 
Published: February 2018

TAF6, bearing the histone H4‐like histone‐fold domain (HFD), is a subunit of the core TAF module in TFIID and SAGA transcriptional regulatory complexes. We isolated and characterized several yeast TAF6 mutants bearing amino acid substitutions in the HFD, the middle region or the HEAT repeat domain. The TAF6 mutants were highly defective for transcriptional activation by the Gcn4 and Gal4 activators. CHIP assays showed that the TAF6‐HFD and the TAF6‐HEAT domain mutations independently abrogated the promoter occupancy of TFIID and SAGA complex in vivo. We employed genetic and biochemical assays to identify the relative contributions of the TAF6 HFD and HEAT domains. First, the temperature‐sensitive phenotype of the HEAT domain mutant was suppressed by overexpression of the core TAF subunits TAF9 and TAF12, as well as TBP. The HFD mutant defect, however, was suppressed by TAF5 but not by TAF9, TAF12 or TBP. Second, the HEAT mutant but not the HFD mutant was defective for growth in the presence of transcription elongation inhibitors. Third, coimmunoprecipitation assays using yeast cell extracts indicated that the specific TAF6 HEAT domain residues are critical for the interaction of core TAF subunits with the SAGA complex but not with TFIID. The specific HFD residues in TAF6, although required for heterodimerization between TAF6 and TAF9 recombinant proteins, were dispensable for association of the core TAF subunits with TFIID and SAGA in yeast cell extracts. Taken together, the results of our studies have uncovered the non‐overlapping requirement of the evolutionarily conserved HEAT domain and the HFD in TAF6 for transcriptional activation.
A morphogram for silica‐witherite biomorphs and its application to microfossil identification in the early earth rock record
Authors: Rouillard J. , García‐Ruiz J.‐M. , Gong J. , van Zuilen M. A. 
Published: February 2018

AbstractArchean hydrothermal environments formed a likely site for the origin and early evolution of life. These are also the settings, however, were complex abiologic structures can form. Low‐temperature serpentinization of ultramafic crust can generate alkaline, silica‐saturated fluids in which carbonate–silica crystalline aggregates with life‐like morphologies can self‐assemble. These “biomorphs” could have adsorbed hydrocarbons from Fischer–Tropsch type synthesis processes, leading to metamorphosed structures that resemble carbonaceous microfossils. Although this abiogenic process has been extensively cited in the literature and has generated important controversy, so far only one specific biomorph type with a filamentous shape has been discussed for the interpretation of Archean microfossils. It is therefore critical to precisely determine the full distribution in morphology and size of these biomorphs, and to study the range of plausible geochemical conditions under which these microstructures can form. Here, a set of witherite‐silica biomorph synthesis experiments in silica‐saturated solutions is presented, for a range of pH values (from 9 to 11.5) and barium ion concentrations (from 0.6 to 40 mmol/L BaCl2). Under these varying conditions, a wide range of life‐like structures is found, from fractal dendrites to complex shapes with continuous curvature. The size, spatial concentration, and morphology of the biomorphs are strongly controlled by environmental parameters, among which pH is the most important. This potentially limits the diversity of environments in which the growth of biomorphs could have occurred on Early Earth. Given the variety of the observed biomorph morphologies, our results show that the morphology of an individual microstructure is a poor criterion for biogenicity. However, biomorphs may be distinguished from actual populations of cellular microfossils by their wide, unimodal size distribution. Biomorphs grown by diffusion in silica gel can be differentiated by their continuous gradient in size, spatial density, and morphology along the direction of diffusion.
Adaptation of global land use and management intensity to changes in climate and atmospheric carbon dioxide
Authors: Alexander Peter , Rabin Sam , Anthoni Peter , Henry Roslyn , Pugh Thomas A. M. , Rounsevell Mark D. A. , Arneth Almut 
Published: February 2018

AbstractLand use contributes to environmental change, but is also influenced by such changes. Climate and atmospheric carbon dioxide (CO2) levels’ changes alter agricultural crop productivity, plant water requirements and irrigation water availability. The global food system needs to respond and adapt to these changes, for example, by altering agricultural practices, including the crop types or intensity of management, or shifting cultivated areas within and between countries. As impacts and associated adaptation responses are spatially specific, understanding the land use adaptation to environmental changes requires crop productivity representations that capture spatial variations. The impact of variation in management practices, including fertiliser and irrigation rates, also needs to be considered. To date, models of global land use have selected agricultural expansion or intensification levels using relatively aggregate spatial representations, typically at a regional level, that are not able to characterise the details of these spatially differentiated responses. Here, we show results from a novel global modelling approach using more detailed biophysically derived yield responses to inputs with greater spatial specificity than previously possible. The approach couples a dynamic global vegetative model (LPJ‐GUESS) with a new land use and food system model (PLUMv2), with results benchmarked against historical land use change from 1970. Land use outcomes to 2100 were explored, suggesting that increased intensity of climate forcing reduces the inputs required for food production, due to the fertilisation and enhanced water use efficiency effects of elevated atmospheric CO2 concentrations, but requiring substantial shifts in the global and local patterns of production. The results suggest that adaptation in the global agriculture and food system has substantial capacity to diminish the negative impacts and gain greater benefits from positive outcomes of climate change. Consequently, agricultural expansion and intensification may be lower than found in previous studies where spatial details and processes consideration were more constrained.
Climate change accelerates local disease extinction rates in a long‐term wild host–pathogen association
Authors: Zhan Jiasui , Ericson Lars , Burdon Jeremy J. 
Published: February 2018

AbstractPathogens are a significant component of all plant communities. In recent years, the potential for existing and emerging pathogens of agricultural crops to cause increased yield losses as a consequence of changing climatic patterns has raised considerable concern. In contrast, the response of naturally occurring, endemic pathogens to a warming climate has received little attention. Here, we report on the impact of a signature variable of global climate change – increasing temperature – on the long‐term epidemiology of a natural host–pathogen association involving the rust pathogen Triphragmium ulmariae and its host plant Filipendula ulmaria. In a host–pathogen metapopulation involving approximately 230 host populations growing on an archipelago of islands in the Gulf of Bothnia we assessed changes in host population size and pathogen epidemiological measures over a 25‐year period. We show how the incidence of disease and its severity declines over that period and most importantly demonstrate a positive association between a long‐term trend of increasing extinction rates in individual pathogen populations of the metapopulation and increasing temperature. Our results are highly suggestive that changing climatic patterns, particularly mean monthly growing season (April‐November) temperature, are markedly influencing the epidemiology of plant disease in this host–pathogen association. Given the important role plant pathogens have in shaping the structure of communities, changes in the epidemiology of pathogens have potentially far‐reaching impacts on ecological and evolutionary processes. For these reasons, it is essential to increase understanding of pathogen epidemiology, its response to warming, and to invoke these responses in forecasts for the future.
Niche packing and expansion account for species richness–productivity relationships in global bird assemblages
Authors: Pellissier Vincent , Barnagaud Jean‐Yves , Kissling W. Daniel , Şekercioğlu Çağan , Svenning Jens‐Christian 
Published: February 2018

AbstractAimNiche theory proposes that increases in species richness along an environmental gradient are associated with a packing of species inside the niche space or an expansion of the niche space. We test whether and under what conditions an increase in bird species richness along a gradient of resource availability is associated with an expansion or packing of the niche as measured based on traits related to resource use.LocationGlobal.Time periodCurrent.Major taxa studiedBirds.MethodsWe measured birds' realized niche space as the standardized departure between observed total trait range and its null expectation (functional richness: SES.FRic) in 12,188 cells worldwide. We first correlated both species richness and this measurement along the global net primary productivity (NPP) gradient using linear regressions. Second, we investigated the non‐stationarity of the species richness–NPP relationship with Lee's bivariate correlation, a measure of the spatial association of two variables. We then assessed the number of cells exhibiting a significant positive species richness–NPP association and a significant negative or positive SES.FRic. Third, we assessed whether species of species‐rich assemblages occur within or outside the niche space of species‐poor assemblages.ResultsAt a global scale, we found that species richness and SES.FRic increased with NPP. We also showed that cells with a significant positive association between species richness and NPP exhibited niche packing (1,699 assemblages out of 12,188) more than niche expansion (five assemblages). Niche packing was associated with complex biomes such as tropical rain forests. Finally, by showing that species in species‐rich assemblages predominantly occur within the niche space of species‐poor assemblages, we showed that the increase in SES.FRic with NPP contributed little to the increase in species richness.Main conclusionAlthough niche volume increases with species richness along an NPP gradient, we confirmed that niche packing is the pattern most associated with the species richness–NPP relationship at a global scale.
Spatial, road geometric and biotic factors associated with Barn Owl mortality along an interstate highway
Authors: Arnold Erin M. , Hanser Steven E. , Regan Tempe , Thompson Jeremy , Lowe Melinda , Kociolek Angela , Belthoff James R. 
Published: February 2018

Highway programmes typically focus on reducing vehicle collisions with large mammals because of economic or safety reasons, while overlooking the millions of birds that die annually from traffic. We studied wildlife–vehicle collisions along an interstate highway in southern Idaho, USA, with among the highest reported rates of American Barn Owl Tyto furcata road mortality. Carcass data from systematic and ad hoc surveys conducted in 2004–2006 and 2013–2015 were used to explore the extent to which spatial, road geometric and biotic factors explained Barn Owl–vehicle collisions. Barn Owls outnumbered all other identified vertebrate species of roadkill and represented > 25% of individuals and 73.6% of road‐killed birds. At a 1‐km highway segment scale, the number of dead Barn Owls decreased with increasing numbers of human structures, cumulative length of secondary roads near the highway and width of the highway median. The number of dead Barn Owls increased with higher commercial average annual daily traffic (CAADT), small mammal abundance index and grass rather than shrubs in the roadside verge. The small mammal abundance index was also greater in roadsides with grass vs. mixed shrubs, suggesting that Barn Owls may be attracted to grassy portions of the highway with more abundant small mammals for hunting prey. When assessed at a 3‐km highway segment scale, the number of dead Barn Owls again increased, with higher CAADT as well as with greater numbers of dairy farms. At a 5‐km scale, the number of dead Barn Owls increased with a greater percentage of cropland near the highway. Although human conversion of the environment from natural shrub‐steppe to irrigated agriculture in this region of Idaho has probably enhanced habitat for Barns Owls, it simultaneously has increased risk for owl–vehicle collisions where an interstate highway traverses the altered landscape. We review some approaches for highway mitigation and suggest that reducing wildlife–vehicle collisions involving Barn Owls may contribute to the persistence of this species.