bluuebunny/crossref_metadata_2025_split huggingface dataset:
The facilitators and challenges of dying at home with dementia: A narrative synthesis
Authors: Mogan Caroline , Lloyd-Williams Mari , Harrison Dening Karen , Dowrick Christopher 
Published: May 2018

Background: It is reported that, given the right support, most people would prefer to die at home, yet a very small minority of people with dementia do so. At present, knowledge gaps remain on how best to support end-of-life care at home for people with dementia. Aim: To identify and understand the challenges and facilitators of providing end-of-life care at home for people with dementia. Design: Narrative synthesis of qualitative and quantitative data. Data sources: The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic literature search was conducted across six electronic databases (AMED, BNI, CINAHL, EMBASE, MEDLINE and PsycINFO) and reference lists of key journals were searched up to July 2017. Results: Searches returned 1949 unique titles, of which seven studies met all the eligibility criteria (four quantitative and three qualitative). Six key themes were identified – four facilitators and two challenges. Facilitators included ‘support from health care professionals’, ‘informal caregiver resilience and extended social networks’, ‘medications and symptom management’ and ‘appropriate equipment and home adaptations’. Challenges included ‘issues with professional services’ and ‘worsening of physical or mental health’. Conclusion: People with dementia may not always require specialist palliative care at the end of life. Further research is required to overcome the methodological shortcomings of previous studies and establish how community development approaches to palliative care, such as compassionate communities, can support families to allow a greater number of people with dementia to die at home.
Survey of North American Multidisciplinary Cleft Palate and Craniofacial Team Clinic Administration
Authors: Pfeifauf Kristin D. , Patel Kamlesh B. , Snyder-Warwick Alison , Skolnick Gary B. , Scheve Sibyl , Naidoo Sybill D. 
Published: May 2018

Objective: This study aims to provide an understanding of the ways cleft palate (CP) and craniofacial teams address billing, administration, communication of clinical recommendations, appointment scheduling, and diagnosis-specific protocols. Design: An online clinic administration survey was developed using data from an open-ended telephone questionnaire. The online survey was distributed by e-mail to the American Cleft Palate-Craniofacial Association (ACPA) nurse coordinator electronic mailing list, used regularly by the ACPA and its members to communicate with teams. The response was 34.1% (42/123). Two incomplete records were excluded, as were any inconsistent responses of 3 teams submitting duplicate records. Results: Six (15.8%) of 38 teams do not charge for clinic visits. For all other teams, some or all providers bill individually for services (68.4%) or a single lump sum applies (10.5%). Patients of 34 (89.5%) of 38 teams occasionally or often neglect to schedule or attend follow-up appointments. Twenty-six (66.7%) of 39 team directors were plastic surgeons. Phone is a common method of contacting families for scheduling (60.0%) and appointment reminders (82.5%). Most teams’ providers (90.0%) routinely communicate findings to each other during postclinical conference. Most teams saw patients with isolated cleft lip (43.6%), cleft lip and palate (64.1%), or isolated CP (59.0%) annually. Conclusions: The breadth of strategies team clinic administration strategies warrants further exploration of the variations and their effects on patient-centered outcomes including the quality of life, satisfaction, cost, and resource utilization.
A randomised trial comparing spatio-temporal gait parameters after total hip arthroplasty between the direct anterior and direct lateral surgical approaches
Authors: Zomar Bryn O , Bryant Dianne , Hunter Susan , Howard James L , Vasarhelyi Edward M , Lanting Brent A 
Published: May 2018

Introduction: Total hip arthroplasty (THA) is a successful procedure for relieving symptoms of severe osteoarthritis. Surgical approach is a key factor in early recovery and although controversial, little has been written about the direct anterior (DA) approach using objective early measures. Methods: 78 participants were prospectively enrolled to undergo a THA through either a DA or direct lateral (DL) surgical approach. Outcome measures were collected preoperatively and at discharge from the hospital, and 2-, 6- and 12-weeks. Outcome measures included the GAITRite® system to measure gait velocity, stride length, single-limb support and single-limb support symmetry. At each time point participants also completed the Timed Up and Go (TUG), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 12-Item Short-Form Survey (SF-12), Harris Hip Score, and pain visual analog scale (VAS). Results: We found statistically significant differences in gait velocity at discharge, 2-weeks and 6-weeks in favour of the DA group (all p < 0.01). We also found significant differences in favour of the DA group for single-limb support symmetry at 6-weeks ( p < 0.01) and 12-weeks ( p < 0.01). The time to complete the TUG test was also significantly shorter in the DA group at 2-weeks ( p < 0.01) and 6-weeks ( p < 0.01) compared to the DL group. However, there were no statistically significant differences in any of the patient-reported outcomes. Conclusion: The DA surgical approach was found to offer significant early advantages in function compared to the DL group, with no differences in quality of life or pain.
Predictive accuracy of RSA migration thresholds for cemented total hip arthroplasty stem designs
Authors: Teeter Matthew G , McCalden Richard W , Yuan Xunhua , MacDonald Steven J , Naudie Douglas D 
Published: May 2018

Introduction: Radiostereometric analysis (RSA) migration thresholds for cemented total hip stems have been established beyond which an unacceptably high risk of revision is likely to occur. These thresholds are subsidence >0.23 mm or >1.2 mm after 2 years. The purpose of this study was to retrospectively examine after long-term follow-up the predictive accuracy of the two thresholds. Methods: Data from two previous prospective RSA trials with 2 year follow-up for which minimum 10 year survivorship data was available were used. Thirty-six patients received a Spectron stem, 17 patients received an Exeter stem, and 17 patients received a CPCS stem. Subsidence after 2 years was compared to the migration thresholds, and long-term survivorship and clinical outcome scores were obtained. Results: At 2 years, the Spectron stem subsided 0.046 ± 0.160 mm, the Exeter stem subsided 1.218 ± 0.320 mm, and the CPCS stem subsided 0.681 ± 0.246 mm ( p < 0.0001). The Spectron stem passed both thresholds, the Exeter stem failed both thresholds, and the CPCS stem passed 1 and failed 1 threshold. At 10 years, survivorship exceeded 90% for all stems. Conclusion: All stems demonstrated strong 10 year survivorship and equivalent clinical outcome scores, but this success would not have been equally predicted across RSA migration thresholds. Although RSA is a useful predictive tool, care should be taken in applying migration thresholds only to those stem designs they are indicated for, with the threshold of 1.2 mm of subsidence at 2 years being most broadly applicable.
Is computerised 3D templating more accurate than 2D templating to predict size of components in primary total hip arthroplasty?
Authors: Schiffner Erik , Latz David , Jungbluth Pascal , Grassmann Jan P , Tanner Stephan , Karbowski Alfred , Windolf Joachim , Schneppendahl Johannes 
Published: May 2018

Introduction: The aim of this study was to compare the accuracy of preoperative templating in total hip arthroplasty (THA) using conventional 2-dimensional (2D) and computed tomography (CT)-based 3-dimensional (3D) measures. Methods: One hundred and sixteen consecutive primary THAs were analysed. The preoperative diagnosis was primary osteoarthritis in all cases. The 2D templating and the 3D templating were performed by two different residents. All templating results were available for the orthopaedic surgeon performing the procedure. Accuracies with regard to the predicted and actual implant sizes were determined for each procedure. Implantation of the size as planned was defined as “exact”, whereas the use of components within one size larger or smaller (±1) as planned were defined as “accurate.” Results: The 3D templating was significantly more accurate in predicting implant sizing compared to 2D templating for primary total hip arthroplasty (THA). The difference was statistically significant for the cup templating (‘‘exact’’ p = 0.02; ‘‘accurate’’ p = 0.01) and for the stem templating (‘‘exact’’ p = 0.04; ‘‘accurate’’ p = 0.01). Conclusion: Our results support the superiority of 3D templating over 2D templating in predicting implant size.
Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Patients with Knee Osteoarthritis?
Authors: Ong Kevin L. , Runa Maria , Lau Edmund , Altman Roy 
Published: May 2018

Objective There is debate about the effectiveness of intra-articular (IA) hyaluronic acid (HA) injections. We asked the following questions: (1) What is the epidemiology of IA HA use in knee arthroplasty (KA) patients? (2) Is Synvisc associated with a delay to KA? (3) Is there a difference in the delay to KA with the number of HA courses? Design The Optum Clinformatics data set (2006–June 2016) was used to identify patients with knee osteoarthritis (OA). Patients who did not receive IA HA were identified, along with those who received Synvisc or non-Synvisc HA. The median duration from knee OA to KA was compared using quantile regression modeling with propensity score weighting. The trend in time to KA with each HA course was evaluated. Results Of 4,027,848 knee OA patients, 141,305 patients underwent KA. Overall median time from knee OA diagnosis to KA was 1.2 years (average: 1.9 ± 1.9 years; interquartile range of 0.4-2.8 years). HA patients had significantly longer adjusted median time to KA by at least 7 months ( P < 0.001). After adjusting for the time to HA and number of injections, Synvisc patients had 1.7 months longer time to KA than non-Synvisc HA patients ( P < 0.001). There was a trend toward longer time to KA with more HA courses. Conclusions Most KA patients did not use HA (73.7%) and when received, it was associated with a longer median time to KA by at least 7 months, though the cause and effect could not be examined. The delay to KA increased with more HA courses.
Initial medical management in acute type A aortic dissection patients with a thrombosed false lumen in the ascending aorta combining intramural hematoma and retrograde dissection from the descending to the ascending aorta
Authors: Sadamatsu Kenji , Takase Susumu , Sagara Shuichiro , Ohe Kensuke , Nishi Jun-ichiro , Tashiro Hideki , Kosuga Tomokazu , Yasunaga Hiroshi 
Published: May 2018

Background:The feasibility of medical management for select patients with acute type A aortic dissection has been reported from a few institutions. In this study, we retrospectively investigated the safety and feasibility of our conservative approach for patients with type A aortic dissection in daily practice.Methods:From January 2013 to December 2017, 131 consecutive patients were admitted to our institution for acute aortic dissection, including 58 patients of type A. Initial medical management was attempted in select patients who were clinically stable and had a thrombosed false lumen of the ascending aorta without ulcer-like projections in the ascending aorta.Results:Except for nine patients contraindicated for surgery, urgent surgery was performed in 26 patients (SRG group), while 23 patients (MED group) were treated with the initial medical management. The maximum diameter of the ascending aorta was significantly larger in the SRG group than in the MED group. In the MED group, the heart rate and blood pressures were well-controlled at admission to the intensive-care unit, and the systolic blood pressure was further reduced at 24 h after. The in-hospital mortality rates of the MED and SRG groups were 0% and 15%, respectively. During the follow-up period, the survival rate was significantly higher in the MED group than in the SRG group, and the aortic event-free survival at one year was 80%.Conclusions:The initial medical management for select patients with a thrombosed false lumen in the ascending aorta was a safe and feasible strategy in real-world practice.
Markeyite, a new calcium uranyl carbonate mineral from the Markey mine, San Juan County, Utah, USA
Authors: Kampf Anthony R. , Plášil Jakub , Kasatkin Anatoly V. , Marty Joe , Čejka Jiří 
Published: May 2018

ABSTRACTThe new mineral markeyite (IMA2016-090), Ca9(UO2)4(CO3)13·28H2O, was found in the Markey mine, San Juan County, Utah, USA, where it occurs as a secondary phase on asphaltum in association with calcite, gypsum and natrozippeite. The mineral is pale yellowish-green with white streak and fluoresces bright bluish white under a 405 nm laser. Crystals are transparent and have vitreous to pearly lustre. It is brittle, with Mohs hardness 1½ to 2, irregular fracture and three cleavages: perfect on {001}; good on {100} and {010}. The measured density is 2.68 g cm–3. Crystals are blades, flattened on {001} and elongate on [010], exhibiting the forms {100}, {010}, {001}, {110}, {101}, {011} and {111}. Markeyite is optically biaxial (–) with α = 1.538(2), β = 1.542(2) and γ = 1.545(2) (white light); the measured 2V is 81(2)°; the dispersion isr<v(weak); the optical orientation isX=c,Y=b,Z=a; and pleochroism isX= light greenish yellow,YandZ= light yellow (X>Y≈Z). Electron microprobe analyses (energy-dispersive spectroscopy mode) yielded CaO 18.60, UO342.90, CO221.30 (calc.) and H2O 18.78 (calc.), total 101.58 wt.% and the empirical formula Ca8.91(U1.01O2)4(CO3)13·28H2O. The six strongest powder X-ray diffraction lines are [dobsÅ(I)(hkl)]: 10.12(69)(001), 6.41(91)(220,121), 5.43(100)(221), 5.07(33)(301,002,131), 4.104(37)(401,141) and 3.984(34)(222). Markeyite is orthorhombic,Pmmn,a= 17.9688(13),b= 18.4705(6),c= 10.1136(4) Å,V= 3356.6(3) Å3andZ= 2. The structure of markeyite (R1= 0.0435 for 3427Fo> 4σF) contains uranyl tricarbonate clusters (UTC) that are linked by Ca–O polyhedra forming thick corrugated heteropolyhedral layers. Included within the layers is an additional disordered CO3group linking the Ca–O polyhedra. The layers are linked to one another and to interlayer H2O groups only via hydrogen bonds. The structure bears some similarities to that of liebigite.
Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
Authors: Maifrede Silvia , Nieborowska-Skorska Margaret , Sullivan-Reed Katherine , Dasgupta Yashodhara , Podszywalow-Bartnicka Paulina , Le Bac Viet , Solecka Martyna , Lian Zhaorui , Belyaeva Elizaveta A. , Nersesyan Alina , Machnicki Marcin M. , Toma Monika , Chatain Nicolas , Rydzanicz Malgorzata , Zhao Huaqing , Jelinek Jaroslav , Piwocka Katarzyna , Sliwinski Tomasz , Stoklosa Tomasz , Ploski Rafal , Fischer Thomas , Sykes Stephen M. , Koschmieder Steffen , Bullinger Lars , Valent Peter , Wasik Mariusz A. , Huang Jian , Skorski Tomasz 
Published: May 2018

Key Points
FLT3 inhibitor AC220 caused DNA repair defects and sensitized FLT3(ITD)-positive AML stem and progenitor cells to PARP1 inhibitors. Quiescent and proliferating FLT3(ITD)-positive AML cells were eliminated by the combination of FLT3 and PARP1 inhibitors.
The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma
Authors: Rasche Leo , Angtuaco Edgardo J. , Alpe Terri L. , Gershner Grant H. , McDonald James E. , Samant Rohan S. , Kumar Manoj , Van Hemert Rudy , Epstein Joshua , Deshpande Shayu , Tytarenko Ruslana , Yaccoby Shmuel , Hillengass Jens , Thanendrarajan Sharmilan , Schinke Carolina , van Rhee Frits , Zangari Maurizio , Walker Brian A. , Barlogie Bart , Morgan Gareth J. , Davies Faith E. , Weinhold Niels 
Published: May 2018

Key Points
The presence of ≥3 large focal lesions is associated with poor outcome in newly diagnosed myeloma patients. The prognostic impact of multiple large focal lesions is independent of R-ISS, GEP70, and extramedullary disease.
User-centered design of a depth data based obstacle detection and avoidance system for the visually impaired
Authors: Jafri Rabia , Khan Marwa Mahmoud 
Published: May 2018

AbstractThe development of a novel depth-data based real-time obstacle detection and avoidance application for visually impaired (VI) individuals to assist them in navigating independently in indoors environments is presented in this paper. The application utilizes a mainstream, computationally efficient mobile device as the development platform in order to create a solution which not only is aesthetically appealing, cost-effective, lightweight and portable but also provides real-time performance and freedom from network connectivity constraints. To alleviate usability problems, a user-centered design approach has been adopted wherein semi-structured interviews with VI individuals in the local context were conducted to understand their micro-navigation practices, challenges and needs. The invaluable insights gained from these interviews have not only informed the design of our system but would also benefit other researchers developing similar applications. The resulting system design along with a detailed description of its obstacle detection and unique multimodal feedback generation modules has been provided. We plan to iteratively develop and test the initial prototype of the system with the end users to resolve any usability issues and better adapt it to their needs.
Epidemiology of carbapenem-resistant Klebsiella pneumoniae bloodstream infections after renal transplantation from donation after cardiac death in a Chinese hospital: a case series analysis
Authors: Wang Yuxi , Lei Hong , Zhang Yuxiang , Yang Qiwen , Wang Yu , Wang Jiaxing , Xu Cheng , Yu Jinggang , Zhou Lili , Kang Xiaoni , Cui Lei 
Published: May 2018

Abstract
Background
Although the high mortality rates have been extensively reported worldwide, few studies have investigated the epidemiology of CRKP-BSIs in the early stage after kidney transplantation (KTx) from donation after cardiac death (DCD). We sought to describe the epidemiological and clinical characteristics of cases of carbapenem resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) in kidney transplantation recipients (KTRs) from DCD in our hospital.

Methods
A retrospective analysis of clinical data of CRKP-BSIs in KTRs admitted to a Chinese hospital in Beijing, China, between January 1, 2012 and December 31, 2016 was performed. The annual percentage of patients with CRKP, the annual number of total KTRs and KTRs from DCD were determined. The genetic relatedness of the strains was determined by polymerase chain reaction and pulse field gel electrophoresis (PFGE).

Results
During the study period, there were total 947 KTRs in our hospital, including 275 KTRs from DCD. Five incidences of CRKP-BSIs in KTRs were identified, and two of them (Case 1,3) from the same foreign hospital. The incidence of CRKP-BSIs in the early stage (within 3 months) following kidney transplantation (KTx) from DCD was about 1.1% (3/275). In Case 1–3 and 5, the rupture of renal transplant artery was presented on the 40th, 16th, 43th and 74th day after KTx, and in Case 4, the thrombus of renal transplant artery was presented on the 13th day after KTx. Three cases (Case 1,2,5) occurring pneumothorax on the 45th, 51th and 32th day after KTx. Four cases (Case 1–4) received the excision of the transplanted kidney for the treatment. Polymerase chain reaction showed the bands for case 2 were distinctive from other cases. Pulse field gel electrophoresis showed mainly three clusters of the bands for all the isolates.

Conclusions
During the study period, we observed an increase in the occurrence of CRKP-BSIs among KTRs from DCD in our hospital. We demonstrated that rupture/thrombus of the renal transplant artery was associated with CRKP-BSI in the early stage after KTx from DCD. Albeit the low incidence of CRKP-BSI (1.1%) after KTx from DCD, the high mortality (4/5) had been observed from the prognosis of the patients. Thorough surveillance of DCD donors, early identification of CRKP-BSI, necessary preventative measurements and use of appropriate treatments should be the strategy for CRKP-BSI in the early stage after KTx from DCD.
A retrospective cohort study: Do patients with graves’ disease need to be euthyroid prior to surgery?
Authors: Al Jassim Abrar , Wallace Tim , Bouhabel Sarah , Majdan Agnieszka , Hier Michael , Forest Veronique-Isabelle , Payne Richard 
Published: May 2018

Background The 2016 American Thyroid Association guidelines indicate that patients with Graves’ disease who undergo a thyroidectomy should be rendered euthyroid through the use of antithyroid drugs (ATD) prior to surgery to avoid complications such as a thyroid storm. At times, the use of ATDs can have limited efficacy and therefore some patients will inevitably remain biochemically hyperthyroid at the time of surgery. The aim of this study is to assess if hyperthyroid patients undergoing a thyroidectomy are at an increased risk of developing a thyroid storm in comparison to euthyroid patients. Furthermore, this study seeks to establish a correlation between thyroid storm identified by the levels of thyroid hormones (T3 and T4) and the level of thyroid stimulating hormone (TSH). Methods A retrospective cohort study was conducted at two Canadian centers, one in Montreal and the other in Nova Scotia. Sixty-seven patients undergoing thyroidectomy for Graves’ disease from January 2006 to December 2016 were evaluated. Results The study comprised 67 participants with a mean age of 46 years (range16–78 years). A total of 78% of patients were on methimazole, 34% on beta-blockers, 27% on potassium iodine solution, 10% on propylthiouracil and 7% on steroids. At the time of surgery 21% were in an overt hyperthyroid state and 33% were in a subclinical hyperthyroid state. The average TSH level of 0.03 mIUL/L (range 0.01–0.23 mIUL/L). Sixteen percent of patients had a TSH level less than 0.01 mIUL/L. The average free T4 level was 29.58 pmol/L (range 11.5–95.2 pmol/L). The average total T3 level was 11.52 nmol/L (range 4.5–29.1 nmol/L) and free T3 level was 6.35 pmol/L (range 6.1–6.6 pmol/L). No patient developed thyroid storm. Conclusions In our study, biochemically hyperthyroid patients undergoing thyroidectomy did not develop thyroid storm. Additional studies with larger sample sizes are needed to better understand the risk of thyroid storm in hyperthyroid patients.
Lipid metabolism reprogramming and its potential targets in cancer
Authors: Cheng Chunming , Geng Feng , Cheng Xiang , Guo Deliang 
Published: May 2018

AbstractReprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element‐binding proteins (SREBPs), a family of membrane‐bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up‐regulated in various cancers and promote tumor growth. SREBP cleavage‐activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti‐cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.