bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major shifts in gut microbiota during development and its relationship to growth in ostriches
Authors: Videvall Elin , Song Se Jin , Bensch Hanna M. , Strandh Maria , Engelbrecht Anel , Serfontein Naomi , Hellgren Olof , Olivier Adriaan , Cloete Schalk , Knight Rob , Cornwallis Charlie K. 
Published: March 2019

AbstractThe development of gut microbiota during ontogeny is emerging as an important process influencing physiology, immunity and fitness in vertebrates. However, knowledge of how bacteria colonize the juvenile gut, how this is influenced by changes in the diversity of gut bacteria and to what extent this influences host fitness, particularly in nonmodel organisms, is lacking. Here we used 16S rRNA gene sequencing to describe the successional development of the faecal microbiome in ostriches (Struthio camelus,n = 66, repeatedly sampled) over the first 3 months of life and its relationship to growth. We found a gradual increase in microbial diversity with age that involved multiple colonization and extinction events and a major taxonomic shift in bacteria that coincided with the cessation of yolk absorption. Comparisons with the microbiota of adults (n = 5) revealed that the chicks became more similar in their microbial diversity and composition to adults as they aged. There was a five‐fold difference in juvenile growth during development, and growth during the first week of age was strongly positively correlated with the abundance of the genusBacteroidesand negatively correlated withAkkermansia.After the first week, the abundances of six phylogenetically diverse families (Peptococcaceae, S24‐7, Verrucomicrobiae, Anaeroplasmataceae, Streptococcaceae, Methanobacteriaceae) were associated with subsequent reductions in chick growth in an age‐specific and transient manner. These results have broad implications for our understanding of the development of gut microbiota and its associations with animal growth.
‘Scripture Grows with its Readers’: Doctrinal Development from a Ricœurian Perspective
Authors: Aspray Barnabas 
Published: March 2019

AbstractThis article uses the hermeneutic philosophy of Paul Ricœur to contribute to a Protestant‐ecumenical understanding of doctrinal development, construed as the growth of the meaning of Scripture. Ricœur’s hermeneutics differ from those of Gadamer, structuralism, and authorial intention in ways that, unlike these, show how doctrinal development is not only possible but necessary. With a Ricœurian approach to biblical interpretation, I argue that doctrinal and even dogmatic development is fully compatible with a Protestant commitment to sola scriptura.
Oral Prolonged‐Release Oxycodone‐Naloxone: Analgesic Response, Safety Profile, and Factors Influencing the Response in Patients With Advanced Cancer
Authors: Corli Oscar , Iorno Vittorio , Legramandi Lorenzo , Rulli Eliana , Roberto Anna , Azzarello Giuseppe , Schiavon Stefania , Cavanna Luigi , De Santis Stefano , Cartoni Claudio , Di Marco Pierangelo , Dauri Mario , Mistretta Rosario , Bortolussi Roberto , Clerico Mario , Pacchioni Manuela , Crispino Carlo , Marabese Mirko , Corsi Nicole ,   Good Response with Appropriate Treatment (GREAT) Collaborators
Published: March 2019

AbstractBackgroundOxycodone‐naloxone (OXN) aims to reduce opioid‐related constipation while being successfully analgesic.MethodsWe evaluated the analgesic response, prevalence, and severity of side effects in 176 patients with cancer who had moderate to severe pain and were being treated with OXN. Patients were followed for 28 days and evaluated every 7 days. Pain intensity, changes of therapy, and adverse drug reactions were recorded at each visit. The primary efficacy endpoint was the proportion of responders (≥30% reduction of pain intensity from baseline to final) and final average pain score ≤ 4 on a scale of 0 to 10.ResultsAverage and worst pain intensity and breakthrough pain (BTP) prevalence decreased over time, and 81.3% of patients were responders. The starting daily dose of OXN was raised from 25.1 ± 13.0 mg to 44.1 ± 29.9 mg, and dose escalation > 5%/day was observed in 19.4% of patients; 40.8% to 46.2% and 11.0% to 17.0% experienced any constipation and a severe grade of constipation during the follow‐up visit, respectively. Digestive system tumor, thyroid endocrinopathies, psychological irritability, and BTP increased the risk for analgesic nonresponse.ConclusionsOXN had a strong analgesic effect in patients with moderate to severe cancer pain; the safety profile is in line with the common adverse effects of opioids, and severe constipation was uncommon.Clinical Trial Registration: NCT02293785.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: March 2019

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 3S Adalberto Felipe Martinez, Federal University of São Carlos, BrazilEnisa Mede, Bahcesehir University, TurkeyFroilan D. Mobo, Philippine Merchant Marine Academy, PhilippineGianpiero Greco, University of Study of Bari, ItalyGuilherme Tucher, Universidade Federal do Rio de Janeiro (UFRJ), Brazilİbrahim Yaşar Kazu, Firat University, TurkeyJohn Cowan, Edinburgh Napier University, UKJon S. Turner, Missouri State University, USALorna T. Enerva, Polytechnic University of the Philippines, PhilippinesMassimiliano Barattucci, Ecampus University, ItalyMatt Varacallo, University of Kentucky, USAMeral Seker, Alanya Alaaddin Keykubat University, TurkeyMichael Wall, Independent Researcher in Music and Music Education, USANiveen M. Zayed, MENA College of Management, JordanRichard Penny, University of Washington Bothell, USASadia Batool, Preston University Islamabad, PakistanSayim Aktay, Mugla Sitki Kocman University, TurkeyVjacheslav Ivanovich Babich, Luhansk Taras Shevchenko National University, Ukraine Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
Neighborhood-level and individual-level socioeconomic status and self-reported management of ischaemic heart disease: cross-sectional results from the Korea Health Examinees Study
Authors: Heo Jongho , Oh Juhwan , Lee Hwa-Young , Choi Ji-Yeob , Kim Sujin , Subramanian S V , Lee Jong-Koo , Kang Daehee 
Published: March 2019

ObjectiveSeveral studies identified neighbourhood context as a predictor of prognosis in ischaemic heart disease (IHD). The present study investigates the relationships of neighborhood-level and individual-level socioeconomic status with the odds of ongoing management of IHD, using baseline survey data from the Korea Health Examinees-Gem study.DesignIn this cross-sectional study, we estimated the association of the odds of self-reported ongoing management with the neighborhood-level income status and percentage of college graduates after controlling for individual-level covariates using two-level multilevel logistic regression models based on the Markov Chain Monte Carlo function.SettingA survey conducted at 17 large general hospitals in major Korean cities and metropolitan areas during 2005–2013.Participants2932 adult men and women.Outcome measureThe self-reported status of management after incident angina or myocardial infarction.ResultsAt the neighbourhood level, residence in a higher-income neighbourhood was associated with the self-reported ongoing management of IHD, after controlling for individual-level covariates [OR: 1.22, 95% credible interval (CI): 1.01 to 1.61). At the individual level, higher education was associated with the ongoing IHD management (high school graduation, OR: 1.33, 95% CI: 1.08 to 1.65); college or higher, OR: 1.63, 95% CI: 1.22 to 2.12; reference, middle school graduation or below).ConclusionsOur study suggests that policies or interventions aimed at improving the quality and availability of medical resources in low-income areas may associate with ongoing IHD management. Moreover, patient-centred education is essential for ongoing IHD management, especially when targeted to patients with IHD with a low education level.
Measuring the efficiency of health systems in Asia: a data envelopment analysis
Authors: Ahmed Sayem , Hasan Md Zahid , MacLennan Mary , Dorin Farzana , Ahmed Mohammad Wahid , Hasan Md Mehedi , Hasan Shaikh Mehdi , Islam Mohammad Touhidul , Khan Jahangir A M 
Published: March 2019

ObjectiveThis study aims to estimate the technical efficiency of health systems in Asia.SettingsThe study was conducted in Asian countries.MethodsWe applied an output-oriented data envelopment analysis (DEA) approach to estimate the technical efficiency of the health systems in Asian countries. The DEA model used per-capita health expenditure (all healthcare resources as a proxy) as input variable and cross-country comparable health outcome indicators (eg, healthy life expectancy at birth and infant mortality per 1000 live births) as output variables. Censored Tobit regression and smoothed bootstrap models were used to observe the associated factors with the efficiency scores. A sensitivity analysis was performed to assess the consistency of these efficiency scores.ResultsThe main findings of this paper demonstrate that about 91.3% (42 of 46 countries) of the studied Asian countries were inefficient with respect to using healthcare system resources. Most of the efficient countries belonged to the high-income group (Cyprus, Japan, and Singapore) and only one country belonged to the lower middle-income group (Bangladesh). Through improving health system efficiency, the studied high-income, upper middle-income, low-income and lower middle-income countries can improve health system outcomes by 6.6%, 8.6% and 8.7%, respectively, using the existing level of resources. Population density, bed density, and primary education completion rate significantly influenced the efficiency score.ConclusionThe results of this analysis showed inefficiency of the health systems in most of the Asian countries and imply that many countries may improve their health system efficiency using the current level of resources. The identified inefficient countries could pay attention to benchmarking their health systems within their income group or other within similar types of health systems.
The views of public and clinician stakeholders on risk assessment tools for post-stroke dementia: a qualitative study
Authors: Tang Eugene , Exley Catherine , Price Christopher , Stephan Blossom , Robinson Louise 
Published: March 2019

ObjectiveStroke-survivors are at increased risk of future dementia. Assessment to identify those at high risk of developing a disease using predictive scores has been utilised in different areas of medicine. A number of risk assessment scores for dementia have been developed but none has been recommended for use clinically. The aim of this qualitative study was to assess the acceptability and feasibility of using a risk assessment tool to predict post-stroke dementia.DesignQualitative semi-structured interviews were conducted and analysed thematically. The patients and carers were offered interviews at around 6 (baseline) and 12 (follow-up) months post-stroke; clinicians were interviewed once.SettingThe study was conducted in the North-East of England with stroke patients, family carers and healthcare professionals in primary and secondary care.ParticipantsThirty-nine interviews were conducted (17 clinicians and 15 stroke patients and their carers at baseline. Twelve stroke patients and their carers were interviewed at follow-up, some interviews were conducted in pairs).ResultsBarriers and facilitators to risk assessment were discussed. For the patients and carers the focus for facilitators were based on the outcomes of risk assessment for example assistance with preparation, diagnosis and for reassurance. For clinicians, facilitators were focused on the process that is, familiarity in primary care, resource availability in secondary care and collaborative care. For barriers, both groups focused on the outcome including for example, the anxiety generated from a potential diagnosis of dementia. For the patients/carers a further barrier included concerns about how it may affect their recovery. For clinicians there were concerns about limited interventions and how it would be different from standard care.ConclusionsRisk assessment for dementia post-stroke presents challenges given the ramifications of a potential diagnosis of dementia. Attention needs to be given to how information is communicated and strategies developed to support the patients and carers if risk assessment is used.
LiMn2O4nanopowders synthesized via gelatin-assisted sol–gel method: Optimization of pH and calcination temperature
Authors: Azad Nasrin , Arabi Hadi , Ghorbani Shaban Reza , Davodi Ali 
Published: March 2019

In this research, LiMn2O4nanopowders were synthesized via sol–gel method using gelatin as a novel chelating agent. The effect of temperature and pH on the structure, morphology and particle size of synthesized powders has been investigated by the differential thermal analysis (DTA), the X-ray diffraction (XRD), the Fourier transform infrared (FTIR) and the field-emission scanning electron microscope (FESEM). The crystal structure of LiMn2O4was completely formed without any impurity phase at a calcination temperature of 750[Formula: see text]C. The peak intensity ratio of I[Formula: see text]/I[Formula: see text], which presents the stability of LiMn2O4structure, is bigger for the sample with pH[Formula: see text]=[Formula: see text]4 than that of the samples with pH[Formula: see text]=[Formula: see text]7 and 8. The sample with pH[Formula: see text]=[Formula: see text]4 has smaller particles of about 70 nm, with more homogeneity and less agglomeration than that of the other samples. At calcination temperature to 850[Formula: see text]C, the size of the particles has become bigger and the particle surfaces show more clarity in all samples. The effect of the pH value on electrochemical properties was studied by galvanostatic charge/discharge tests. The results show more capacity lost for the sample with pH[Formula: see text]=[Formula: see text]8 with regards to the other samples.
Spectrum of SYK model III: Large deviations and concentration of measures
Authors: Feng Renjie , Tian Gang , Wei Dongyi 
Published: March 2019

In [Spectrum of SYK model, preprint (2018), arXiv:1801.10073], we proved the almost sure convergence of eigenvalues of the SYK model, which can be viewed as a type of law of large numbers in probability theory; in [Spectrum of SYK model II: Central limit theorem, preprint (2018), arXiv:1806.05714], we proved that the linear statistic of eigenvalues satisfies the central limit theorem. In this paper, we continue to study another important theorem in probability theory — the concentration of measure theorem, especially for the Gaussian SYK model. We will prove a large deviation principle (LDP) for the normalized empirical measure of eigenvalues when [Formula: see text], in which case the eigenvalues can be expressed in terms of these of Gaussian random antisymmetric matrices. Such LDP result has its own independent interest in random matrix theory. For general [Formula: see text], we cannot prove the LDP, we will prove a concentration of measure theorem by estimating the Lipschitz norm of the Gaussian SYK model.
Augmented Dyadic Therapy Boosts Recovery of Language Function in Patients With Nonfluent Aphasia
Authors: Grechuta Klaudia , Rubio Ballester Belén , Espín Munne Rosa , Usabiaga Bernal Teresa , Molina Hervás Begona , Mohr Bettina , Pulvermüller Friedemann , San Segundo Rosa , Verschure Paul 
Published: March 2019

Background and Purpose—
Evidence suggests that therapy can be effective in recovering from aphasia, provided that it consists of socially embedded, intensive training of behaviorally relevant tasks. However, the resources of healthcare systems are often too limited to provide such treatment at sufficient dosage. Hence, there is a need for evidence-based, cost-effective rehabilitation methods. Here, we asked whether virtual reality-based treatment grounded in the principles of use-dependent learning, behavioral relevance, and intensity positively impacts recovery from nonfluent aphasia.

Methods—
Seventeen patients with chronic nonfluent aphasia underwent intensive therapy in a randomized, controlled, parallel-group trial. Participants were assigned to the control group (N=8) receiving standard treatment or to the experimental group (N=9) receiving augmented embodied therapy with the Rehabilitation Gaming System for aphasia. All Rehabilitation Gaming System for aphasia sessions were supervised by an assistant who monitored the patients but did not offer any elements of standard therapy. Both interventions were matched for intensity and materials.

Results—

Our results revealed that at the end of the treatment both groups significantly improved on the primary outcome measure (Boston Diagnostic Aphasia Examination: control group,
P
=0.04; experimental group,
P
=0.01), and the secondary outcome measure (lexical access—vocabulary test: control group,
P
=0.01; experimental group,
P
=0.007). However, only the Rehabilitation Gaming System for aphasia group improved on the Communicative Aphasia Log (
P
=0.01). The follow-up assessment (week 16) demonstrated that while both groups retained vocabulary-related changes (control group,
P
=0.01; experimental group,
P
=0.007), only the Rehabilitation Gaming System for aphasia group showed therapy-induced improvements in language (
P
=0.01) and communication (
P
=0.05).

Conclusions—
Our results demonstrate the effectiveness of Rehabilitation Gaming System for aphasia for improving language and communication in patients with chronic aphasia suggesting that current challenges faced by the healthcare system in the treatment of stroke might be effectively addressed by augmenting traditional therapy with computer-based methods.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02928822.
The Aristotelian Psychology of Tragic Mimesis
Authors: González José M. 
Published: March 2019

AbstractThis paper argues that the psychology of mimesis presupposed by Poetics 4 is immediately relevant to Aristotle’s psychology of tragic mimesis. µανθάνειν καὶ συλλογίζεσθαι at 1448b16 involve a cognitive mode characteristic of Aristotelian induction that joins particulars with universals through spontaneous, non-discursive noetic predication. Aristotle’s view of the cognition of tragic mimesis can be subsumed under the practice of theōria: the inductive re‑cognition of ethical universals is a ‘theoric’ exercise of philosophical reflection on the particulars of the tragic action, an associative intellection that actualizes the subject’s knowledge by joining ethical universals with the particular mimetic praxeis they regard.
Transcendence in an Age of Tabloids and Terror
Authors: Carson Jordan 
Published: March 2019

Abstract
This essay examines how Don DeLillo employs the apophatic tradition as a means of approaching the transcendent while resisting media absorption and extremist cooptation. Apophatic discourse—discourse that points toward that which is beyond language—honors the dynamic nature of truth, making it well suited to a postmodern, pluralistic era. Yet, apophasis is not just a recognition of the limits of language but a way of approaching the Ultimate that results in personal transformation. DeLillo’s invocation of mystery is often noted but rarely connected to spiritual formation. Yet his work is full of pilgrims disaffected by traditional religion who unavailingly seek spiritual fulfillment elsewhere. I demonstrate that DeLillo offers a standard for discriminating among religious mysteries by chronicling the spiritual etiolation of misguided pilgrims. I then identify apophatic discourse in his work, arguing that DeLillo upholds apophasis as a way of engaging mystery that is self-realizing and redemptive.
Wind Turbine Clutter Mitigation via Nonconvex Regularizers and Multidimensional Processing
Authors: Hu Yinan , Uysal Faruk , Selesnick Ivan 
Published: March 2019

AbstractThis paper generalizes a previous formulation of signal separation problem for dynamic wind turbine clutter mitigation at weather radar systems. In this modified formulation, we use nonconvex regularizers together with multichannel overlapping group shrinkage (MOGS) to penalize weather signals and adopt multidimensional processing. We show the restored weather signals in plan position indicator (PPI) format and, to demonstrate the improvement, compare them with the ones produced by the previous method in reflectivity, spectral width, and Doppler velocity estimates of weather data. The improvement results from a better characterization of the sparsities of the weather radar returns. During the course of experiments, we observe that the proposed method successfully mitigates the wind turbine clutter and dramatically increases the signal-to-clutter ratio, even for different weather and wind turbine signatures. In addition, when the wind turbine clutter is weak in the mixture, our algorithm manages to attenuate the ground clutters and produces clutter-free weather signals favorable for further processing.
Swallowing Function in Survivors of Oropharyngeal Cancer Is Associated With Advanced T Classification
Authors: Harms Aaron , Kansara Sagar , Stach Carol , Richardson Peter A. , Chen George , Lai Syeling , Sikora Andrew G. , Parke Robert , Donovan Donald , Chiao Elizabeth , Skinner Heath , Sandulache Vlad C. 
Published: March 2019

Objectives:The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing in the United States. The aim of this study was to characterize the functional status of OPSCC survivors to identify predictors of swallowing dysfunction in this patient population.Methods:OPSCC survivors (n = 81) treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2005 and 2015 with at least 2 years of clinical follow-up were reviewed. Functional status was ascertained using (1) gastrostomy and tracheostomy placement and retention, (2) gastrostomy use at last follow-up, (3) patient-reported diet, and (4) modified barium swallow.Results:Median follow-up duration was 5.6 years; 67% of patients had ≥10-pack-year tobacco exposure; 96% of tumors for which p16 data were available were p16 positive. At last follow-up, 82% of patients reported a regular diet, and only 9 patients required gastrostomy use. Gastrostomy use at last follow-up was higher in patients with T3 and T4 tumors compared with those with T1 and T2 tumors ( P = .01). The relationship between T classification and gastrostomy use persisted even when the analysis was limited to p16+ tumors and p16+ tumors with ≥10-pack-year history of tobacco exposure.Conclusions:Advanced T classification at presentation is a critical predictor of gastrostomy use in long-term OPSCC survivors irrespective of p16 status or tobacco exposure history.Level of Evidence:2b