bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13)
Authors: Bortot Maria , Ashworth Katrina , Sharifi Alireza , Walker Faye , Crawford Nathan C. , Neeves Keith B. , Bark David , Di Paola Jorge 
Published: July 2019

Objective—
Acquired von Willebrand syndrome is defined by excessive cleavage of the VWF (von Willebrand Factor) and is associated with impaired primary hemostasis and severe bleeding. It often develops when blood is exposed to nonphysiological flow such as in aortic stenosis or mechanical circulatory support. We evaluated the role of laminar, transitional, and turbulent flow on VWF cleavage and the effects on VWF function.

Approach and Results—
We used a vane rheometer to generate laminar, transitional, and turbulent flow and evaluate the effect of each on VWF cleavage in the presence of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type-1 motif, member 13). We performed functional assays to evaluate the effect of these flows on VWF structure and function. Computational fluid dynamics was used to estimate the flow fields and forces within the vane rheometer under each flow condition. Turbulent flow is required for excessive cleavage of VWF in an ADAMTS13-dependent manner. The assay was repeated with whole blood, and the turbulent flow had the same effect. Our computational fluid dynamics results show that under turbulent conditions, the Kolmogorov scale approaches the size of VWF. Finally, cleavage of VWF in this study has functional consequences under flow as the resulting VWF has decreased ability to bind platelets and collagen.

Conclusions—
Turbulent flow mediates VWF cleavage in the presence of ADAMTS13, decreasing the ability of VWF to sustain platelet adhesion. These findings impact the design of mechanical circulatory support devices and are relevant to pathological environments where turbulence is added to circulation.
In Defence of Speculative Materialism
Authors: Moir Cat 
Published: July 2019

Abstract
Ernst Bloch’s recourse to speculative philosophy has guaranteed him the position of a perpetual outsider in the history of Western Marxism. When Jürgen Habermas described Bloch’s philosophy in 1960 as a ‘speculative materialism’, it was to denounce him for crossing the boundaries of critical thought set down as much by Kant’s Critique of Pure Reason as by Marx’s critique of political economy. This article argues that Bloch’s speculative materialism deserves to be re-assessed. Contrary to Habermas’s assertion that speculation is divorced from critique, I argue with Bloch that (1) the speculative hypotheses we unavoidably use to interpret the world around us inform our political beliefs and actions, and (2) to stifle speculative thinking as that creative and inquisitive enterprise which questions and transgresses the given is not only a ‘crime against reason’, as Hilary Putnam once claimed, but also a crime against freedom.
Postnarrativism, Historiographical Evaluation, and Truth
Authors: Bricker Adam Michael 
Published: July 2019

Abstract
The problem of historiographical evaluation is simply this: By what evaluative criteria might we say that certain works of historiography are better than others? One recently proposed solution to this problem comes by way of Kuukkanen’s postnarrativist philosophy of historiography.1 Kuukkanen argues that because many historiographically interesting statements lack truth-values, we cannot evaluate historiographical claims on a truth-functional basis. In the place of truth, Kuukkanen suggests that we evaluate historiographical claims in terms of justification. The problem with this proposal, as I will argue here, is that it isn’t at all clear what it means for a neither-true-nor-false claim to be justified. Moreover, this proposal also runs into trouble with the factivity of knowledge. The solution I propose here might be called “two-valued” postnarrativism, which retains Kuukkanen’s framework, except with a stricter ontology devoid of neither-true-nor-false historiographical statements.
In arguing for this approach to historiographical evaluation, this paper will be structured in the following way: First, I’ll describe Kuukkanen’s postnarrativism in more detail, focusing especially on his account of historiographical evaluation (§1). Next, I’ll introduce two problems that accompany this account, one originating from the factivity of knowledge (§2) and the other from trying to divorce justification from the concept of truth (§3). Finally, I argue that not only might these problems be solved by simply committing to all historiographical claims being either true or false, but that Kuukkanen’s account is especially amenable to this (§4).
The Functions and Use of Roman Coinage
Authors: Kemmers Fleur 
Published: July 2019

Abstract
In this publication Fleur Kemmers gives an overview of 21st century scholarship on Roman coinage for students and scholars in the fields of ancient history and Roman archaeology. First, it addresses the study of numismatics as a discipline and the theoretical and methodological advances of the last decades. Secondly, it provides guidelines for how to consult numismatic reference works, including those available online. Recent scholarly approaches and insights in the functions of Roman coins as both vehicles of political communication and instruments for state payments are critically assessed. Furthermore, the publication reviews the evidence for a conscious monetary policy on the part of the Roman authorities. Finally, the impact of Roman expansion and imperialism on monetisation and coin use in Rome´s Empire is discussed.
Spindle Cell Lipomas of the Respiratory Tract: A Case Report and Comprehensive Literature Review
Authors: Reid Jonathan , Wehrli Bret , Sowerby Leigh J. 
Published: July 2019

Background: Spindle cell lipomas (SCLs) are benign tumors that are characteristically present on the upper back and neck, but in rare cases present throughout the respiratory mucosa, causing hoarseness, stridor, dyspnea, and obstruction. Objective: To highlight the importance of considering SCL in the diagnosis of benign respiratory tract tumors, a literature review identified all published cases of respiratory tract SCLs, including 2 from our institution: one case in the nasopharynx and 1 in the nasal valve. Methods: All case reports, series and literature reviews from the English literature from 1975 through March 2018 were systematically identified for review in the MEDLINE, EMBASE, and Scopus databases. Two additional cases from our institution were described. Results: In total, 24 cases of SCL in the respiratory tract were identified for review. Two cases from our institution are described here, bringing the total of reported cases to 26. Extensive analyses of oral cavity SCLs already exist, so we excluded this site from our review and focused on sites where SCLs may present with respiratory symptoms. Excluding the oral cavity and oropharynx, the most common location described is the larynx. All 26 cases were treated with excision. One tumor required a second surgery, but there were no other complications nor recurrences. Conclusion: Although rare, SCLs may arise from throughout the respiratory tract and cause dyspnea, hoarseness and stridor. Spindle cell lipoma should be considered in the differential diagnosis of a respiratory tract mass. This diagnosis confers a good prognosis and patients may be reassured that surgery is almost always curative.
Cartridge-based nucleic acid amplification test: a novel rapid diagnostic tool to study the burden of tuberculosis from a tertiary care hospital
Authors: Kashyap Bineeta , Goyal Nisha , Hyanki Puneeta , Singh NP , Khanna Ashwani 
Published: July 2019

Despite efforts to limit the morbidity and mortality from tuberculosis (TB), it continues to be an important cause of death. There is an urgent need for a diagnostic test that accurately and quickly diagnoses TB, especially if it is also a near-point-of-care test. The GeneXpert polymerase chain reaction test (known in India as CBNAAT [cartridge-based nucleic acid amplification test] and is capable of diagnosing TB and rifampicin resistance within 2 h) is a promising tool. The duration of our study was two years and was carried out in the DOTS centre of a tertiary care hospital in India. A total of 5449 samples were processed using CBNAAT. Of the total samples tested, 2068 were extra-pulmonary. The following information was collected: number of extra-pulmonary samples processed; number of Mycobacterium tuberculosis ( M. tuberculosis)-positive samples; patterns of rifampicin sensitivity; number of people living with HIV (PLHIV); and number of children. Of the samples, 62.1% were from suspected pulmonary TB patients. Out of the total samples tested using CBNAAT, 21.8% were positive for M. tuberculosis. Rifampicin resistance was seen in 9.2%, 8.5% and 10.3% of the total, pulmonary and extra-pulmonary samples, respectively, in M. tuberculosis-positive samples. Overall, 36.9% samples were from the paediatric population and 5.7% belonged to PLHIV. Rifampicin resistance was seen in 8.8% and 8.3% of the M. tuberculosis-positive paediatric and PLHIV samples, respectively.
Five-year outcomes of mechano-chemical ablation of primary great saphenous vein incompetence
Authors: Thierens Naomi DE , Holewijn Suzanne , Vissers Wynand HPM , Werson Debbie AB , de Vries Jean Paul PM , Reijnen Michel MPJ 
Published: July 2019

Objective The aim of the study is to report long-term results after mechano-chemical ablation for the treatment of great saphenous vein incompetence. Methods Mechano-chemical ablation was performed using the ClariVein device with polidocanol as the sclerosant. Clinical-Etiologic-Anatomic-Pathophysiologic (CEAP) classification, Venous-Clinical-Severity-Score (VCSS), anatomical-success, RAND-SF36 and the Aberdeen-Varicose-Vein-Questionnaire (AVVQ) were obtained by clinical examination, questionnaires and duplex ultrasonography through five years’ follow-up (Clinicaltrials.gov, NCT01459263). Results Ninety-four patients (113 great saphenous veins) were included in the study. Five-year follow-up data were available for 75 limbs (66.4%). Freedom from anatomical failure was 78.7% (N = 45) with 64.6% (N = 42) having an improvement in the VCSS ≥1. A total of five reinterventions were performed through five years with a median time to reintervention of 38 months. The VCSS at five years was 2 (IQR 1; 4) and was still significantly improved compared to baseline (p < 0.001). A deterioration of the VCSS was observed in 21.5%. Conclusion Through five-year follow-up, there are a significant number of anatomical and clinical failures in this series, mainly driven by partial recanalizations.
Introducing the Lateral Femoral Condyle Index as a Risk Factor for Anterior Cruciate Ligament Injury
Authors: Hodel Sandro , Kabelitz Method , Tondelli Timo , Vlachopoulos Lazaros , Sutter Reto , Fucentese Sandro F. 
Published: July 2019

Background: The asymmetry of the medial and lateral knee compartments contributes significantly to femorotibial biomechanics and pivoting, and it is reported to be a relevant risk factor for an anterior cruciate ligament (ACL) injury. Purpose: (1) To assess the role of femoral condyle sphericity as a risk factor for an ACL rupture and rerupture. (2) To compare the new risk factor with existing bony morphological risk factors via magnetic resonance imaging (MRI) and to assess the most predictive risk factor for an ACL rupture. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective case-control study of 60 patients was conducted. Three age- and sex-matched cohorts (each n = 20) were analyzed: ACL reruptures, primary ACL ruptures, and a control group consisting of isolated meniscal tears or patients with anterior knee pain without signs of trochlear dysplasia. The lateral femoral condyle index (LFCI) as a novel MRI measurement was developed to quantify femoral sphericity. In addition, previously known MRI risk factors associated with ACL injury were analyzed (notch width index, medial tibial slope, lateral tibial slope, medial tibial depth, and lateral tibial height). Differences among groups were compared; cutoff values were defined; and diagnostic performance of the risk factors was assessed. The risk factors were subsequently analyzed with multiple logistic regression. Results: The LFCI was significantly smaller in knees with ACL reruptures (median, 0.67; range, 0.59-0.75) and primary ACL ruptures (0.67; range, 0.60-0.75) than in the control group (0.76; range, 0.6-0.81; P < .01). The LFCI yielded the highest area under the curve among the analyzed risk factors: 0.82 (95% CI, 0.7-0.9). A cutoff of 0.70 yielded a sensitivity of 78% and a specificity of 80% to predict an ACL rupture or rerupture (odds ratio, 13.79; 95% CI, 3.67-51.75). In combination with lateral tibial height (cutoff, 3.8 mm) and lateral tibial slope (cutoff, 2.9°), the diagnostic performance was improved. The area under the curve was 0.86 (95% CI, 0.75-0.94), with a sensitivity of 90% and a specificity of 70% (odds ratio, 21.00; 95% CI, 5.10-85.80). Conclusion: A decreased LFCI is associated with an ACL injury. The LFCI, lateral tibial height, and lateral tibial slope are the most predictive risk factors for an ACL injury. These findings might aid clinicians in identifying patients at risk for an ACL injury and inform the patient after reconstruction for a higher risk of rerupture.
The Prosecution of Anti-Jewish Crimes in Bulgaria: Fashioning a Master Narrative of the Second World War (1944–1945)
Authors: Ragaru Nadège 
Published: July 2019

Bulgaria was amongst the first states in Europe to hold trials with an exclusive focus on anti-Jewish persecutions during the Second World War. On 24 November 1944, a chamber solely dedicated to the prosecution of anti-Jewish crimes was established within the People’s Courts (1944–1945). This judicial action thus constitutes a unique experiment in the qualification of crimes, the use of material/testimonial evidence, the establishment of proof, and the devising of sentencing policy. Seen as a stage on which several contenders fought over the reading of the recent past and the present in the making, the Court also offers a lens on the complex interplay between the prosecution of war crimes and the crafting of revolutionary changes as well as on the relations between Jews and non-Jews at the end of the war. Drawing on a diversity of archival records (accusation files and protocols of the hearings among others), the article will underline two paradoxes. First, the chamber established to prosecute anti-Jewish crimes ended up building a master narrative of “collective innocence” centered on the “rescue of the Bulgarian Jews,” which has remained dominant in Bulgarian public discourse to this day. Second, the communist Jews who had fought for the recognition of Jewish suffering ultimately took part in the euphemization of Jewish experiences of the war. In resorting to justice, they hoped to convince the local Jewry to stay in Bulgaria and build socialism there. For that purpose, they had to prove that the wartime policies were the deeds of a handful of “fascists.” Henceforth, they embraced the official discourse of interethnic solidarity in combat and sorrow, thus downplaying the specificity of the Jewish predicament.
A quasi-experimental evaluation of an intervention to increase palliative medicine referral in the emergency department
Authors: Tiernan Eoin , Ryan John , Casey Mary , Hale Aine , O’Reilly Valerie , Devenish Millie , Whyte Barbara , Hollingsworth Siobhan , Price Olga , Callanan Ian , Walsh Declan , Normand Charles , May Peter 
Published: July 2019

Objective To evaluate a new intervention intended to increase referral rates from the emergency department (ED) to the palliative medicine service (PMS) in acute hospitals. Methods We conducted a quasi-experimental evaluation in an urban teaching hospital in Dublin, Ireland. Data were collected over two eight-week periods in November/December 2013 and May/June 2015, with the PALliative Medicine in the Emergency Department (PAL.M.ED.™) intervention implemented in the intervening period. All adults who were admitted to the hospital via the ED during the two time periods and who received a palliative care consultation during their hospital stay were included in the study. Our primary analysis evaluated the impact of PAL.M.ED.™ on PMS referral in the ED. Our secondary analysis evaluated the impact of PMS referral in the ED on length of stay (LOS) and utilization, compared to PMS referral later in the admission. We controlled for observed confounding between groups using propensity scores. Results PAL.M.ED.™ was associated with an increase in PMS referral in the ED ( p < 0.005; odds ratio: 10.5 (95%CI: 3.8 to 28.7)). PMS referral in the ED was associated with shorter hospital LOS ( p < 0.005; −10.9 days (95%CI: −17.7 to −4.1)). Conclusions Low PMS referral rates in the ED, and the poor outcomes for patients and hospitals that arise from admissions of those with serious illness, may be mitigated by a proactive intervention to identify appropriate patients at admission.
Can a telemonitoring system lead to decreased hospitalization in elderly patients?
Authors: Lyth Johan , Lind Leili , Persson Hans L , Wiréhn Ann-Britt 
Published: July 2019

Introduction Growing populations of elderly patients with chronic obstructive pulmonary disease (COPD) or heart failure (HF) require more healthcare. A four-year telehealth intervention – the Health Diary system based on digital pen technology – was implemented. We hypothesized that study patients with advanced COPD or HF would have lower rates of hospitalization when using the Health Diary. The aim was to investigate the effects of the intervention on healthcare costs and the number of hospitalizations, as well as other care required in COPD and HF patients. Methods Patients were introduced to the telemonitoring system which was supervised by a specialized hospital-based home care (HBHC) unit. Staff associated with this unit were responsible for the healthcare provided. The study included patients with COPD or HF, aged ≥ 65 years who were frequently hospitalized due to exacerbations – at least two inpatient episodes within the last 12 months. Observed number of hospitalizations and total healthcare costs were compared with the expected values, which were calculated using the generalized estimating equations (GEE) method. Results A total of 36 COPD and 58 HF patients with advanced stages of disease were included. The number of hospitalizations was significantly reduced for both HF and COPD patients participating in telemonitoring. Accordingly, hospitalization costs were significantly reduced for both groups, but the total healthcare cost was not significantly different from the expected costs. Conclusion A telemonitoring system, the Health Diary, combined with a specialized HBHC unit significantly decreases the need for hospital care in elderly patients with advanced HF or COPD without increasing total healthcare costs.
Positive fluid balance and mortality in adult patients treated with extracorporeal membrane oxygenation: A retrospective study
Authors: Fong Ka Man , Au Shek Yin , Ng George Wing Yiu , Leung Anne Kit Hung 
Published: July 2019

Background Intravenous fluid is important for resuscitation and maintenance of circuit flow in patients with extracorporeal membrane oxygenation, but fluid overload is widely recognized as detrimental in critically ill patients. This study aimed to evaluate the association between positive fluid balance and outcomes in adult patients treated with extracorporeal membrane oxygenation. Methods This was a retrospective observational study of a tertiary hospital from October 2010 to January 2018. Patients aged ≥18 years who received extracorporeal membrane oxygenation for ≥48 h were included. The fluid balance was determined as the difference between fluid intake and fluid output, and the cumulative fluid balance was calculated as the sum of these values on the preceding days. The primary outcome was hospital mortality. Results Of the 123 included extracorporeal membrane oxygenation episodes, 79 were venovenous extracorporeal membrane oxygenation. The hospital mortality rate was 31.7%. Seventy-eight patients underwent continuous renal replacement therapy during their extracorporeal membrane oxygenation course. Non-survivors had a greater cumulative fluid balance (p≤0.001) and a lower cumulative fluid output (p = 0.006) than survivors on day 7. Fluid intake was not significantly different between survivors and non-survivors (p = 0.583). In the multivariate analysis, the cumulative fluid balance (per litre) on day 7, but not on day 3, was associated with increased hospital mortality (adjusted OR: 1.17, 95% CI: 1.06–1.29, p = 0.001). Conclusions In adult patients treated with extracorporeal membrane oxygenation, a higher positive cumulative fluid balance on day 7 was associated with increased hospital mortality. The association between positive fluid balance and mortality was mainly influenced by lower fluid output rather than an increase in fluid intake.
Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study
Authors: Cernohorsky Paul , Strackee Simon D. , Streekstra Geert J. , van den Wijngaard Jeroen P. , Spaan Jos A. E. , Siebes Maria , van Leeuwen Ton G. , de Bruin Daniel M. 
Published: July 2019

Objective Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired CT data, 3-dimensional realignment of the OCT data to the curved intraarticular trajectory was performed for all probe positions. The scanned TMC joints were processed using a cryomicrotome imaging system. Finally, cartilage thickness measurements between OCT and cryomicrotome data were compared. Results Successful visualization of TMC articular cartilage was performed using OCT. The CT-mediated registration yielded a digital reconstruction of the articular surface on which thickness measurements could be performed. A near-perfect agreement between OCT and cryomicrotome thickness measurements was found ( r2 = 0.989). Conclusion The proposed approach enables 3D reconstruction of the TMC articular surface with subsequent accurate cartilage thickness measurements, encouraging the development of intraarticular cartilage OCT for future (clinical) application.