bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro antioxidants and anti-inflammatory potentials of high protein-fibre cookies produced from whole wheat, sweet potato, rice bran and peanut composite flour blends
Authors: Udeh Charles Chiedu , Malomo Sunday Abiodun , Ijarotimi Oluwole Steve 
Published: November 2024

AbstractThe growing demand for low-cost and functional snacks in many developing nations called for interest in the use of locally grown crops as substitutes for costly imported wheat flour. The amino acid composition, antioxidant and anti-inflammatory properties of the cookies from whole wheat, sweet potato, rice bran and peanut (56.25:18.75:5:20; 37.50:37.50:5:20; 18.75:56.25:5:20% as WPRG 1, WPRG 2, WPRG 3) composite flour blends, respectively, were obtained in this study. The 100% whole wheat and 100% refined flours served as control 1 and 2, respectively. The level of hydrophobic and aromatic amino acids was significantly (p < 0.05) high in WPRG 2 (~ 30 and ~ 10%), respectively when compared to others. However, the branched chain amino acids and Fischer ratio was significantly (p < 0.05) high in WPRG 1 (11.40% and 1.29), respectively, which could have contributed to their improved bioactivities. Notably, the composite cookie samples WPRG 1, 2 and 3 had higher hydroxyl (73.86 − 84.16%), DPPH (76.52 − 84.60%) radical scavenging as well as ferric reducing antioxidant (0.64–0.87 mmolFe2+/mg) properties than the control samples WWF and CWF, respectively. On the contrary, the metal chelating activities of the cookies WPRG 1–3 were not significantly (p > 0.05) different from control samples WWF and CWF. The improved amino acid profile and enhanced antioxidant properties of the composite cookies might have effectively influenced their anti-inflammatory properties (IC50; < 26 μg/ml) when compared to the control samples (IC50; ~ 40 μg/ml), respectively. Hence, the cookies that comprised of antioxidants and anti-inflammatory potentials needed in human health, were acceptable by the consumers.

Graphical Abstract
Mismatch negativity in tinnitus patient in relation to cortisol level
Authors: Fayed Menna M. , Nosair Nahla A. , Gabr Takwa A. 
Published: November 2024

Abstract

Background
The main aim of this study was the evaluation of mismatch negativity (MMN) in tinnitus patients in relation to serum cortisol levels. This study was designed to evaluate mismatch negativity (MMN) in tinnitus patients in relation to serum cortisol levels. For such purpose, MMN response and cortisol level were compared in tinnitus patients with normal hearing in comparison to normal hearing control. The methodology included full history taking, basic audiological evaluation, MMN, and the serum cortisol level measured at 9:00 am in addition to a tinnitus questionnaire in the study group only.

Results
There was a statistically significant delayed MMN latency in the study group in both the right and left ear in comparison to the control group. Regarding MMN amplitude, it was significantly reduced in the left ear in comparison to the left ear of the control. As regards the cortisol level, it was significantly increased in the study group when compared with the control group.

Conclusion
Mismatch negativity can be used to evaluate echoic memory in tinnitus patients. Additionally, serum cortisol levels can be used as an effective indicator of stress status and psychological condition in tinnitus patients.
Bi-directional regulation between inflammation and stem cells in the respiratory tract
Authors: Choi Jinwook , Chudziak Jakub , Lee Joo-Hyeon 
Published: November 2024

ABSTRACT
Inflammation plays a crucial role in tissue injury, repair and disease, orchestrating a complex interplay of immune responses and cellular processes. Recent studies have uncovered the intricate connection between inflammation and stem cell dynamics, shedding light on the central role of stem cells in tissue regeneration. This Review highlights the significance of inflammation in shaping epithelial stem cell dynamics and its implications for tissue repair, regeneration and aging. We explore the multifaceted interactions between inflammation and stem cells, focusing on how inflammatory signals affect stem cell behavior and fate as well as the remodeling of their niche in the respiratory tract. We also discuss the concept of ‘inflammatory memory’ in epithelial stem cells, where prior inflammatory stimuli endow these cells with enhanced regenerative potential and confer long-lasting protective mechanisms for maintaining tissue integrity and function. Furthermore, we review the impact of cell senescence induced by inflammation on tissue regeneration and aging, delving into the molecular mechanisms underlying the modulation of signaling pathways, epigenetic modifications and cellular crosstalk. Understanding these dynamic processes not only deepens our knowledge of tissue homeostasis and repair but also holds profound implications for regenerative medicine strategies aimed at preventing pulmonary diseases.
influence of allergens on the development of selected ENT diseases in the pediatric population
Authors: Snoch Olga , Kalinowska Zuzanna , Ratajczak Aleksandra , Matera Weronika 
Published: November 2024

There is substantial evidence that allergies are a significant factor triggering and exacerbating many ENT diseases. The problem is particularly visible in the pediatric population, of which as many as 20% suffer from some form of atopy. Moreover, the course of these conditions is more complex than previously thought. The aim of the study was to collect information on the most common diseases in otorhinolaryngology and their link with hypersensitivity to allergens. The literature review included allergic rhinitis, adenoid hypertrophy, otitis media and sinusitis. Owing to a better understanding of the pathogenesis of these diseases, pediatricians can effectively treat and prevent their development.
Sosialisasi Studi Komposisi Unsur Garam Tambak pada Masyarakat di Wilayah Kecamatan Pangarengan, Sampang, Madura: Tahap Awal Pengembangan Potensinya sebagai Bahan Baku Baterai Ion Sodium
Authors: Astuti Fahmi , Indrawati Susilo , Fatimah Iim , Puspitasari Nurrisma 
Published: November 2024

Pangarengan merupakan salah satu kecamatan di Kabupaten Sampang yang masyarakatnya banyak berprofesi sebagai petani garam, sehingga banyak produk garam yang dihasilkan di wilayah ini. Kegiatan pengabdian masyarakat bertajuk studi komposisi unsur garam tambak di Kecamatan Pangarengan, Sampang, Madura telah dilaksanakan oleh tim dari Departemen Fisika Institut Teknologi Sepuluh Nopember. Pengujian X-Ray Fluorescence (XRF) dilakukan untuk mengetahui unsur yang terkandung dalam garam tambak dan dari hasil ini dapat digunakan untuk mengetahui kualitas dan potensi yang bisa dikembangkan terutama dalam hal riset. Dari hasil XRF didapatkan informasi bahwa beberapa unsur seperti sodium (Na), chlorine (Cl), calcium (Ca), zirconium (Zr), neodymium (Nd), aluminium (Al), phosphorus (P), copper (Cu), dan bromine (Br) merupakan kandungan unsur dalam sampel garam tambak Pangarengan yang diuji. Hasil ini serupa dengan beberapa studi kandungan garam tambak pada penelitian yang dilakukan di daerah lainnya. Unsur Na dan Cl yang cukup dominan pada garam tambak Pangarengan dapat dijadikan sebagai informasi awal ataupun acuan terkait kandungan garam tambak Pangarengan dan ke depannya dapat dipakai sebagai referensi untuk pengembangan serta pemanfaatan hasil alam dan mineral di Indonesia, misalnya sebagai bahan dasar pembuatan baterai ion sodium. Dari kegiatan ini, masyarakat petani garam di Kecamatan Pangarengan memiliki tambahan wawasan terkait potensi pemanfaatan garam. Menemukan potensi lain dari garam merupakan salah satu strategi untuk meningkatkan harga jual garam yang akan berdampak nantinya pada kesejahteraan petani garam.
Implementasi Sistem Monitoring Proses Fermentasi dan Kualitas Silase dari Rumput Pakchong pada Bank Pakan Peternakan Sapi Perah
Authors: Wahyuono Ruri Agung , Risanti Doty Dewi , Bawika Gita Widhi , Ningrum Annisa Septyana , Putra Arda Fridua , Christanto Raphael , Islam Muhammad Nuril , Wibowo Wendy Anugerah Putra , Murdianto Satria Ahmadsyah , Sihombing Erick Rafael , Bimatara Zidan Dani , Aptadi Yudhistira Septian , Chandra Yusuf 
Published: November 2024

Peternak sapi perah di Desa Blarang memanfaatkan silase rumput Pakchong sebagai solusi terhadap kelangkaan pakan hijauan selama musim kemarau. Pengujian kualitas silase yang relatif mahal dan kompleks mendorong tim pengabdi merancang sistem pemantauan proses fermentasi dan kualitas silase, yang dilengkapi dengan tiga jenis sensor: sensor MQ135 untuk mendeteksi konsentrasi gas amonia, sensor DHT22 untuk mengukur suhu dan kelembaban, serta sensor pH-4502c untuk memantau tingkat keasaman. Sistem ini juga diintegrasikan dengan teknologi machine learning untuk memprediksi kualitas serta durasi fermentasi silase berdasarkan Keputusan Menteri Pertanian Nomor 430/KPTS/KN.200/M/7/2019. Hasil pemantauan selama 40 hari menunjukkan bahwa kadar air meningkat selama proses fermentasi, namun masih dalam batas yang dapat diterima, tanpa adanya pembusukan akibat jamur. Selain itu, kandungan nutrien silase mengalami peningkatan, sehingga dinyatakan layak untuk dikonsumsi oleh sapi perah. Algoritma machine learning yang digunakan menunjukkan bahwa parameter masukan seperti kadar air, tingkat keasaman, suhu, dan kelembaban udara memiliki korelasi yang kuat dengan parameter keluaran berupa kalsium, fosfor, protein, peptin, dan lemak, namun parameter kadar gas amonia tidak menunjukkan korelasi signifikan terhadap hasil tersebut.
Broadband optical antireflection metasurface design for F-P micro-optical accelerometers
Authors: Yang ZeYu , Liu WenYao , Liu ChenXi , Li Wei , Gu YanXia , Tian HaoYuan , He YuXin , Zhou YanRu , Xing EnBo , Liu Lai , Tang Jun , Liu Jun 
Published: November 2024

The micro-optical accelerometer has the advantages of high sensitivity,
miniaturization, and integration, which has attracted much attention.
Its performance is closely related to parameters such as the intensity
and bandwidth of the transmitted light of the optical resonator.
Therefore, a novel, to our knowledge, single-layer all-dielectric
antireflection structure based on metasurfaces is proposed.
According
to the quantitative relationship between the reflectivity and the
diffraction component of the structure, the antireflection mechanism
of the structure is explored. Then, by optimizing the structural
parameters of the silicon surface unit, a broadband antireflection
range from 415 to 3200 nm is realized, and the transmittance at
1550 nm can reach 99.8%. Finally, the designed metasurface
structure is applied to the Fabry–Perot (F-P) micro-optical
accelerometer, and the sensitivity is three times higher than that of
the Al2O3 antireflection film. This provides
what we believe is a new idea for the integrated design of
micro-optical accelerometer based on all-dielectric metasurfaces.
Change in breath: The effect of rhythm education based practices
Authors: Yıldırım Hikmet , Ayyıldız Durhan Tebessüm , Gökyürek Belgin , Kılıçarslan Ferhat , Baydar Arıcan Hacer Özge , Kaya Didem Gülçin 
Published: November 2024

The aim of this study is to examine the effect of rhythm training practices on the change of breathing values in athletes. In this direction, breathing exercises were conducted with 6 people within the framework of rhythm training practices lasting 14 weeks. In the study in which the pretest-posttest experimental study method was adopted, the data were analyzed with Wilcoxon Signed Ranks Test and Kruskall Wallis test as well as descriptive statistics. The findings obtained were that rhythm training practices in athletes revealed a significant difference in pre-test data on breathing values. Based on the findings obtained as a result of the research, it is evaluated that rhythm training practices, which form the basis of all sports branches, should be considered in a broader framework and integrated into basic training studies in sports branches.
(Extended English summary is at the end of this document)
Özet
Bu çalışmada ritim eğitimi uygulamalarının sporcularda nefes değerlerinin değişimine olan etkisinin incelenmesi amaçlanmaktadır. Bu doğrultuda 6 katılımcı ile 14 hafta süren ritim eğitimi uygulamaları çerçevesinde nefes çalışmaları yapılmıştır. Ön test son test deneysel çalışma yönteminin benimsendiği araştırmada veriler betimsel istatistiklerin yanı sıra Wilcoxon İşaretli Sıralar Testi ve Kruskall Wallis testi ile incelenmiştir. Elde edilen bulgular sporcularda ritim eğitimi uygulamalarının nefes değerlerine yönelik son test verilerinde anlamlı farklılık ortaya çıkarttığı yönündedir. Araştırma sonucunda elde edilen bulgulardan hareketle tüm sportif branşların temelini oluşturan ritim eğitimi uygulamalarının daha geniş çerçevede ele alınarak, spor branşlarındaki temel antrenman çalışmalarına entegre edilmesi gerektiği değerlendirilmektedir.
MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
Authors: Lu Xin , Chen Zhiyuan , Mi Wenting , Zheng Jianming , Liu Yubin 
Published: November 2024

Abstract

Purpose
This study aimed to investigate the role of microtubule-affinity regulatory protein kinase 1 (MARK1) in hepatocellular carcinoma (HCC) progression, its association with sorafenib sensitivity, and the interplay between MARK1 and POTE Ankyrin domain family member E(POTEE) in HCC cells.

Methods
Quantitative real-time polymerase chain reaction analysis was used to assess MARK1 and POTEE expression in 60 pairs of HCC tissues and cell lines. The correlation between MARK1 levels, clinicopathological features, and patient prognosis was analyzed. Sorafenib-resistant HCC cell models were developed, followed by MARK1 overexpression to evaluate its impact on cell functions. Luciferase reporter assays and rescue experiments were conducted to elucidate the MARK1–POTEE regulatory mechanism.

Results
MARK1 exhibited decreased mRNA expression in HCC tissues and cells, correlating with adverse clinicopathological features and poorer patient survival. Luciferase assays confirmed direct binding between MARK1 and POTEE. Sorafenib treatment increased MARK1 protein levels, reduced POTEE, and inhibited cell proliferation. Overexpressing MARK1 suppressed sorafenib-induced proliferation in resistant cells, while co-overexpression of MARK1 and POTEE reversed this effect.

Conclusion
MARK1 potentially restrains HCC progression and enhances sorafenib resistance by negatively modulating POTEE expression, highlighting its significance as a therapeutic target in HCC treatment.
Lower-body strength, power and sprint front crawl performance
Authors: Muniz-Pardos Borja , Gomez-Bruton Alejandro , Matute-Llorente Angel , Gonzalez-Aguero Alex , Olmedillas Hugo , Gomez-Cabello Alba , Casajus Jose A. , Vicente-Rodríguez Germán 
Published: November 2024

Abstract

Purpose
To determine the association between lower-body strength and lower-body power capacities with sprint swimming performance in adolescent competitive swimmers.

Methods
A total of 44 front crawl swimmers (27 males and 17 females) performed anthropometric assessments, lower-body strength tests (half squat maximum isometric strength, dynamic half squat with 20, 30 and 40 % of the maximum isometric strength, and knee extension maximum isometric strength) and lower-body power tests (squat jump [SJ], countermovement jump [CMJ] and Abalakov jump). Further front crawl swimming best times in 50 and 100 m were recorded from official swimming competitions and front crawl technique was assessed by an experienced coach using a visual analogue scale.

Results
Swimming performance was correlated with lower-body power variables (SJ [r=−0.573 for 50 m and −0.642 for 100 m], CMJ [r=−0.497 for 50 m and −0.544 for 100 m], and Abalakov jump [r=−0.452 for 50 m and −0.415 for 100 m]; p≤0.05) and lower-body strength (half squat maximum isometric strength [r=−0.430 for 50 m and −0.443 for 100 m]; p≤0.05) in males but not in females. Further linear regression models showed that only lower-body power predicted both 50 m (Abalakov jump; r2=0.58; change in r2=0.18) and 100 m (SJ; r2=0.66; change in r2=0.15) performance in male swimmers.

Conclusions
This study emphasizes the greater association between lower-body power and sprint front crawl performance in adolescent males compared to females. Practical tests (i.e., SJ and Abalakov jump) are shown to predict front crawl swimming performance, which may facilitate the performance control by coaches and trainers.
Determinants of Foreign Investment in Indonesia Post-Pandemic
Authors: Sulvani Putri , Fafurida Fafurida 
Published: November 2024

Research Originality: The Covid-19 pandemic brought out the phenomenon of a rapid increase in investment after it has ended in Indonesia. This study gives a significant contribution in analyze the impact of pandemic on foreign direct investment.Research Objectives: The aim of this research is to predict whether there is a relationship of interest rates, inflation, labor force, GDP, and exchange rate with investment.Research Methods: This research is also to examine the asymmetric relationship among variables using the NARDL (Nonlinear Autoregressive Distributed Lag) method to identify the long-run effects of these variables on the investment after the Covid-19 pandemic in Indonesia. It uses the secondary data from 1980-2022.Empirical Results: The results of research show that there is a long-run asymmetric effect of the variables of interest rates, GDP, and exchange rates on the foreign direct investment. It means that changes in these variable factors do not only affect the size of investment, but also the speed of its increase after the pandemic. Meanwhile, there is no asymmetric effect of the variables of labor force and inflation on the investment.Implications: This research provides a picture and new insights related to the foreign direct investment dynamics in Indonesia after the Covid-19 pandemic. This study implies that require a different policy approach in an effort to increase the investment in Indonesia.JEL Classification: F21, O40
Interaction of Climate Change and Green Stocks on Economic Growth in ASEAN-5
Authors: Amalia Sopira Qori , Suriani Suriani 
Published: November 2024

Research Originality: This study presents a new interaction of climate change in moderating the effect of green stocks, exchange rates, and net exports on economic growth in ASEAN-5 countries. Research Objectives: This study aims to analyze the interaction of climate change on green stocks, exchange rates, and net exports on economic growth in ASEAN-5 countries. Research Methods: This study used quarterly panel data from ASEAN-5 countries, 2016-2022, and selected a fixed effects model as the best model. The moderated regression analysis (MRA) approach supports this research.Empirical Results: The results showed that green stocks, exchange rates, and net exports positively affect economic growth in ASEAN-5 countries. The interaction of climate change on green stocks and exchange rates has a negative effect on economic growth. However, the interaction of climate change on net exports positively affects economic growth in ASEAN-5 countries. It represents that climate change can weaken the effect of green stocks and exchange rates on economic growth. Meanwhile, climate change can strengthen the effect of net exports on economic growth in ASEAN-5 countries. Implications: This study implies that the government needs to increase investment in green stocks to support financing that can mitigate climate change and develop net exports to increase economic growth toward a green economy. Similarly, the ASEAN-5 central banks, as monetary authorities, can maintain exchange rate fluctuations to achieve stable economic growth.JEL Classification: F31, F43, G11, Q54, Q56
Economic Growth and Environmental Quality: A Study on Mineral-Rich Provinces in Indonesia
Authors: Ramadanti Sarindang Suci , Azwardi Azwardi , Subardin Muhammad 
Published: November 2024

Research Originality: This research focuses on Indonesia's mineral-rich provinces and offers originality through its comprehensive analysis of the bidirectional relationship between economic growth and environmental quality, using the Environmental Quality Index (EQI). Research Objectives: This study examines the relationship between economic growth and environmental quality in the Mineral Economy Provinces of Indonesia.Research Methods: The data used in this research is secondary data from 2015 to 2022. The analysis method employed is the simultaneous equation model using Two Stage Least Squares (2SLS).Empirical Results: The results show that in model 1, economic growth is significantly influenced by exogenous variables such as the environmental quality index, energy consumption, revenue sharing funds, investment, and population. In model 2, environmental quality is significantly influenced by exogenous variables such as GDP, mining output, energy consumption, and forest. Good environmental quality can enhance economic growth. Conversely, increased Economic growth can degrade environmental quality.Implications: The study's findings suggest that policymakers in Indonesia's mineral economy provinces should prioritize sustainable development to balance economic growth with environmental preservation.JEL Classification: Q43, Q50, Q56
Determinants of Paying Zakat Through E-Zakat in Tarakan
Authors: Ichsan Nurul , Fuadiyah Hilmatul 
Published: November 2024

Research Originality: The existence of adequate infrastructure, especially in the Tarakan City area, makes the author utilize the integration of the conceptual approaches of the Technology Acceptance Model and the Theory of Planned Research Objectives: This study aims to analyze the influence of variables from the Technology Acceptance Model (TAM) theory and the Theory of Planned Behavior (TPB) on the interest in paying zakat, infaq, and alms through e-zakat.Research Methods: This study uses primary data from the distribution of questionnaires using the purposive sampling method with 111 respondents who are Muslim and domiciled in Tarakan City. The research method is the Structural Equation Model (SEM) Partial Least Square (PLS) approach.Empirical Results: The results obtained that attitudes and behavioral control have a significant influence on the interest in use, while the perception of usefulness, perception of ease, and subjective norms do not have a significant influence on the interest in paying zakat, infaq, and alms through e -zakat.Implications: The community still feels comfortable and easy to pay ZIS directly and the presence of people close to them or the surrounding environment has not fully provided confidence to the Muslim community of Tarakan City to use e-zakat as a payment service.JEL Classification: H71, H76, Q53