bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria
Authors: Reiterer Friedrich , Scheuchenegger Anna , Resch Bernhard , Maurer‐Fellbaum Ute , Avian Alexander , Urlesberger Berndt 
Published: February 2019

AbstractBackgroundBronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long‐term outcome.MethodsThis was a retrospective, single‐center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24+0–28+6 weeks) with BPD (n = 44), with a cohort of GA‐matched preterm infants without BPD (n = 44) with regard to neonatal morbidity, incidence of lower respiratory tract infection (LRTI), ND outcome and growth to 2 years' corrected age (CA) and preschool age.ResultsBronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028).ConclusionNeonatal respiratory morbidity was significantly higher in the BPD cohort, but long‐term ND outcome did not differ. Infants with BPD had poorer growth.
Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases
Authors: Godown Justin , Hall Matt , Thompson Bryn , Thurm Cary , Jabs Kathy , Gillis Lynette A. , Hafberg Einar T. , Alexopoulos Sophoclis , Karp Seth J. , Soslow Jonathan H. 
Published: February 2019

AbstractDatabase linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart‐lung, and small bowel transplants. All patients (<21 years) who underwent liver, kidney, lung, heart‐lung, or small bowel transplant were identified from the PHIS database using APR‐DRG codes (2002‐2018). Linkage was performed in a stepwise approach using indirect identifiers. Hospital costs were estimated based on hospital charges and cost‐to‐charge ratios, inflated to 2018 dollars and described by transplant type. A total of 14 061 patients overlapped between databases. Of these, 13 388 (95.2%) were uniquely linked. Linkage success ranged from 92.6% to 97.8% by organ system. A total of 12 940 (92%) patients had complete cost data. Hospitalization costs were greatest for patients undergoing small bowel transplantation with a median cost of $734 454 (IQR $336 174 ‐ $1 504 167), followed by heart $565 386 (IQR $352 813 ‐ $999 216), heart‐lung $471 573 (IQR $328 523 ‐ 992 438), lung $303 536 (IQR $215 383 ‐ $612 749), liver $200 448 (IQR $130 880 ‐ $357 897), and kidney transplant $94 796 (IQR $73 157 ‐$131 040). We report a robust linkage between the SRTR and PHIS databases, providing an invaluable tool to assess resource utilization in solid organ transplant recipients. Our analysis provides contemporary cost data for pediatric solid organ transplantation from the largest US sample reported to date. It also provides a platform for expanded analyses in the pediatric transplant population.
P300 development from infancy to adolescence
Authors: Riggins Tracy , Scott Lisa S. 
Published: February 2019

AbstractThis article provides an overview of P300 research from infancy through adolescence. First, a brief historical overview is provided highlighting seminal studies that began exploration of the P300 component in developmental groups. Overall, these studies suggest that the P300 can be detected in children and appears to reflect similar cognitive processes to those in adults; however, it is significantly delayed in its latency to peak. Second, two striking findings from developmental research are the lack of a clear P300 component in infancy and differential electrophysiological responses to novel, unexpected stimuli in children, adolescents, and adults. Third, contemporary questions are described, which include P300‐like components in infancy, alteration of P300 in atypically developing groups, relations between P300 and behavior, individual differences of P300, and neural substrates of P300 across development. Finally, we conclude with comments regarding the power of a developmental perspective and suggestions for important issues that should be addressed in the next 50 years of P300 research.
A common neural substrate for elevated PTSD symptoms and reduced pulse rate variability in combat‐exposed veterans
Authors: Grupe Daniel W. , Imhoff‐Smith Ted , Wielgosz Joseph , Nitschke Jack B. , Davidson Richard J. 
Published: February 2019

AbstractPrevious studies have identified reduced heart rate variability (HRV) in post‐traumatic stress disorder (PTSD), which may temporally precede the onset of the disorder. A separate line of functional neuroimaging research in PTSD has consistently demonstrated hypoactivation of the ventromedial prefrontal cortex (vmPFC), a key aspect of a descending neuromodulatory system that exerts inhibitory control over heart rate. No research to date, however, has simultaneously investigated whether altered vmPFC activation is associated with reduced HRV and elevated PTSD symptoms in the same individuals. Here, we collected fMRI data during alternating conditions of threat of shock and safety from shock in 51 male combat‐exposed veterans with either high or low levels of PTSD symptoms. Pulse rate variability (PRV)—a HRV surrogate calculated from pulse oximetry—was assessed during a subsequent resting scan. Correlational analyses tested for hypothesized relationships between reduced vmPFC activation, lower PRV, and elevated PTSD symptomatology. We found that PTSD re‐experiencing symptoms were inversely associated with high‐frequency (HF)‐PRV, thought to primarily reflect parasympathetic control of heart rate, in veterans with elevated PTSD symptoms. Reduced vmPFC activation for the contrast of safety‐threat was associated both with lower HF‐PRV and elevated PTSD re‐experiencing symptoms. These results tie together previous observations of reduced HRV/PRV and impaired vmPFC function in PTSD and call for further research on reciprocal brain‐body relationships in understanding PTSD pathophysiology.
Ranking the Importance of Genetic Factors by Variable-Selection Confidence Sets
Authors: Zheng Chao , Ferrari Davide , Zhang Michael , Baird Paul 
Published: February 2019

SummaryThe widespread use of generalized linear models in case–control genetic studies has helped to identify many disease-associated risk factors typically defined as DNA variants, or single-nucleotide polymorphisms (SNPs). Up to now, most literature has focused on selecting a unique best subset of SNPs based on some statistical perspective. When the noise is large compared with the signal, however, multiple biological paths are often found to be supported by a given data set. We address the ambiguity related to SNP selection by constructing a list of models—called a variable-selection confidence set (VSCS)—which contains the collection of all well-supported SNP combinations at a user-specified confidence level. The VSCS extends the familiar notion of confidence intervals in the variable-selection setting and provides the practitioner with new tools aiding the variable-selection activity beyond trusting a single model. On the basis of the VSCS, we consider natural graphical and numerical statistics measuring the inclusion importance of an SNP based on its frequency in the most parsimonious VSCS models. This work is motivated by available case–control genetic data on age-related macular degeneration, which is a widespread disease and leading cause of loss of vision.
Identifiability of two‐component skew normal mixtures with one known component
Authors: Jain Shantanu , Levine Michael , Radivojac Predrag , Trosset Michael W. 
Published: February 2019

AbstractWe give sufficient identifiability conditions for estimating mixing proportions in two‐component mixtures of skew normal distributions with one known component. We consider the univariate case and two multivariate extensions: a multivariate skew normal distribution (MSN) and the canonical fundamental skew normal distribution (CFUSN). The characteristic function of the CFUSN distribution is additionally derived.
Patient‐reported scar quality of adults after burn injuries: A five‐year multicenter follow‐up study
Authors: Spronk Inge , Polinder Suzanne , Haagsma Juanita A. , Nieuwenhuis Marianne , Pijpe Anouk , van der Vlies Cornelis H. , Middelkoop Esther , van Baar Margriet E. 
Published: February 2019

AbstractScar formation is an important adverse consequence of burns. How patients appraise their scar quality is often studied shortly after sustaining the injury, but information in the long‐term is scarce. Our aim was, therefore, to evaluate long‐term patient‐reported quality of burn scars. Adults with a burn center admission of ≥1 day between August 2011 and September 2012 were invited to complete a questionnaire on long‐term consequences of burns. We enriched this sample with patients with severe burns (>20% total body surface area [TBSA] burned or TBSA full thickness >5%) treated between January 2010 and March 2013. Self‐reported scar quality was assessed with the Patient Scale of the Patient and Observer Scar Assessment Scale (POSAS). Patients completed this scale for their—in their opinion—most severe scar ≥5 years after burns. This study included 251 patients with a mean %TBSA burned of 10%. The vast majority (91.4%) reported at least minor differences with normal skin (POSAS item score ≥2) on one or more scar characteristics and 78.9% of the patients’ overall opinion was that their scar deviated from normal skin. Patients with severe burns had higher POSAS scores, representing worse scar quality, than patients with mild/intermediate burns, except for color, which was high in both groups. A longer hospital stay predicted reduced scar quality (both mean POSAS and mean overall opinion of the scar) in multivariate analyses. In addition, female gender was also associated with a poorer overall opinion of the scar. In conclusion, this study provides new insights in long‐term scar quality. Scars differed from normal skin in a large part of the burn population more than 5 years after burns, especially in those with severe burns. Female gender is associated with a poorer patients’ overall opinion of their scar, which may be an indication of gender differences in perception of scar quality after burns.
Sphingosine‐1‐phosphate activates mouse vagal airway afferent C‐fibres via S1PR3 receptors
Authors: Patil Mayur J. , Meeker Sonya , Bautista Diana , Dong Xinzhong , Undem Bradley J. 
Published: February 2019

Key points
Sphingosine‐1‐phosphate (S1P) strongly activates mouse vagal C‐fibres in the airways.
Airway‐specific nodose and jugular C‐fibre neurons express mRNA coding for the S1P receptor S1PR3.
S1P activation of nodose C‐fibres is inhibited by a S1PR3 antagonist.
S1P activation of nodose C‐fibres does not occur in S1PR3 knockout mice.
AbstractWe evaluated the effect of sphingosine‐1‐phosphate (S1P), a lipid that is elevated during airway inflammatory conditions like asthma, for its ability to stimulate vagal afferent C‐fibres in mouse lungs. Single cell RT‐PCR on lung‐specific vagal afferent neurons revealed that both TRPV1‐expressing and TRPV1‐non‐expressing nodose neurons express mRNA coding for the S1P receptor S1PR3. TRPV1‐expressing airway‐specific jugular ganglion neurons also express S1PR3 mRNA. S1PR1 and S1PR2 mRNAs were also found to be expressed but only in a limited subset (32% and 22%, respectively) of airway‐specific vagal sensory neurons; whereas S1PR4 and S1PR5 were rarely expressed. We used large scale two‐photon imaging of the nodose ganglia from our ex vivo preparation isolated from Pirt‐Cre;R26‐GCaMP6s transgenic mice, which allows for simultaneous monitoring of calcium transients in ∼1000 neuronal cell bodies in the ganglia during tracheal perfusion with S1P (10 μM). We found that S1P in the lungs strongly activated 81.5% of nodose fibres, 70% of which were also activated by capsaicin. Single fibre electrophysiological recordings confirmed that S1P evoked action potential (AP) generation in a concentration‐dependent manner (0.1–10 μM). Action potential generation by S1P in nodose C‐fibres was effectively inhibited by the S1PR3 antagonist TY 52156 (10 μM). Finally, in S1PR3 knockout mice, S1P was not able to activate any of the airway nodose C‐fibres analysed. These results support the hypothesis that S1P may play a role in evoking C‐fibre‐mediated airway sensations and reflexes that are associated with airway inflammatory diseases.
SMS behaviour change communication and eVoucher interventions to increase uptake of cervical cancer screening in the Kilimanjaro and Arusha regions of Tanzania: a randomised, double-blind, controlled trial of effectiveness
Authors: Erwin Erica , Aronson Kristan J , Day Andrew , Ginsburg Ophira , Macheku Godwin , Feksi Agnes , Oneko Olola , Sleeth Jessica , Magoma Best , West Nicola , Marandu Prisca Dominic , Yeates Karen 
Published: February 2019

BackgroundCervical cancer, although almost entirely preventable through cervical cancer screening (CCS) and human papillomavirus vaccination, is the leading cause of cancer deaths among women in Tanzania. Barriers to attending CCS include lack of awareness of CCS, affordability concerns regarding screening and travel cost. We aimed to compare the effectiveness of SMS (short message service) behaviour change communication (BCC) messages and of SMS BCC messages delivered with a transportation electronic voucher (eVoucher) on increasing uptake of CCS versus the control group.MethodsDoor-to-door recruitment was conducted between 1 February and 13 March 2016 in randomly selected enumeration areas in the catchment areas of two hospitals, one urban and one rural, in Northern Tanzania. Women aged 25–49 able to access a mobile phone were randomised using a computer-generated 1:1:1 sequence stratified by urban/rural to receive either (1) 15 SMS, (2) an eVoucher for return transportation to CCS plus the same SMS, or (3) one SMS informing about the nearest CCS clinic. Fieldworkers and participants were masked to allocation. All areas received standard sensitisation including posters, community announcements and sensitisation similar to community health worker (CHW) sensitisation. The primary outcome was attendance at CCS within 60 days of randomisation.FindingsParticipants (n=866) were randomly allocated to the BCC SMS group (n=272), SMS + eVoucher group (n=313), or control group (n=281), with 851 included in the analysis (BCC SMS n=272, SMS + eVoucher n=298, control group n=281). By day 60 of follow-up, 101 women (11.9%) attended CCS. Intervention group participants were more likely to attend than control group participants (SMS + eVoucher OR: 4.7, 95% CI 2.9 to 7.4; SMS OR: 3.0, 95% CI 1.5 to 6.2).Trial registration numberNCT02680613.
Global sustainability (health, environment and monetary costs) of three dietary patterns: results from a Spanish cohort (the SUN project)
Authors: Fresán Ujué , Martínez-González Miguel Angel , Sabaté Joan , Bes-Rastrollo Maira 
Published: February 2019

ObjectiveTo evaluate the sustainability of the dietary patterns, according to their effects on health and environment and their affordability.DesignProspective, ongoing cohort study of university graduates.SettingsThe Spanish SUN project (Seguimiento Universidad de Navarra, University of Navarra Follow-up), starting from 1999.ParticipantsA total of 18 429 participants.MethodsInformation from participants is collected every 2 years by validated questionnaires. We assessed three dietary patterns (the Mediterranean, the Western and the Provegetarian dietary patterns). The rate advancement period (RAP) was used to assess the healthiness of each pattern (considering the composite endpoint of all-cause mortality, cardiovascular disease, breast cancer or type 2 diabetes). We also assessed environmental footprints and monetary costs of each dietary pattern.ResultsAfter a median follow-up of 10.1 years, we identified 469 incident cases of the composite endpoint. The Mediterranean dietary pattern exhibited the best RAP (3.10 years gained [95% CI 4.35 to 1.85] for the highest vs the lowest quartile), while the Western pattern was the unhealthiest pattern (1.33 years lost when comparing extreme quartiles). In a scale between 4 and 16 of harmful environmental effects (the lower, the more environmentally friendly), the Provegetarian pattern scored best (8.82 [95% CI 8.75 to 8.88] when comparing extreme quartiles), whereas the Western pattern was the most detrimental pattern (10.80 [95% CI 10.72 to 10.87]). Regarding monetary costs, the Western pattern was the most affordable pattern (€5.87/day [95% CI 5.82 to 5.93], for the upper quartile), while the Mediterranean pattern was the most expensive pattern (€7.52/day [95% CI 7.47 to 7.56]). The Mediterranean dietary pattern was the most overall sustainable option, closely followed by the Provegetarian pattern. The least overall sustainable pattern was the Western dietary pattern.ConclusionFollowing plant-based diets, like the Mediterranean or Provegetarian dietary patterns, could be a good option in order to achieve an overall sustainable diet.Trial registration numberNCT02669602; Results.
The ongoing French metastatic breast cancer (MBC) cohort: the example-based methodology of the Epidemiological Strategy and Medical Economics (ESME)
Authors: Pérol David , Robain Mathieu , Arveux Patrick , Mathoulin-Pélissier Simone , Chamorey Emmanuel , Asselain Bernard , Berchery Delphine , Gourgou Sophie , Breton Mathias , Delaine-Clisant Stéphanie , Mons Muriel , Diéras Véronique , Carton Matthieu , Guizard Anne-Valérie , Laborde Lilian , Laurent Carine , Loeb Agnès , Mouret-Reynier Marie-Ange , Parent Damien , Perrocheau Geneviève , Campion Loïc , Velten Michel , Cailliot Christian , Ezzalfani Monia , Simon Gaëtane 
Published: February 2019

PurposeThe currently ongoing Epidemiological Strategy and Medical Economics (ESME) research programme aims at centralising real-life data on oncology care for epidemiological research purposes. We draw on results from the metastatic breast cancer (MBC) cohort to illustrate the methodology used for data collection in the ESME research programme.ParticipantsAll consecutive ≥18 years patients with MBC treatment initiated between 2008 and 2014 in one of the 18 French Comprehensive Cancer Centres were selected. Diagnostic, therapeutic and follow-up data (demographics, primary tumour, metastatic disease, treatment patterns and vital status) were collected through the course of the disease. Data collection is updated annually.Finding to dateWith a recruitment target of 30 000 patients with MBC by 2019, we currently screened a total of 45 329 patients, and >16 700 patients with a metastatic disease treatment initiated after 2008 have been selected. 20.7% of patients had an hormone receptor (HR)-negative MBC, 73.7% had a HER2-negative MBC and 13.9% were classified as triple-negative BC (ie, HER2 and HR status both negative). Median follow-up duration from MBC diagnosis was 48.55 months for the whole cohort.Future plansThese real-world data will help standardise the management of MBC and improve patient care. A dozen of ancillary research projects have been conducted and some of them are already accepted for publication or ready to be issued. The ESME research programme is expanding to ovarian cancer and advanced/metastatic lung cancer. Our ultimate goal is to achieve a continuous link to the data of the cohort to the French national Health Data System for centralising data on healthcare reimbursement (drugs, medical procedures), inpatient/outpatient stays and visits in primary/secondary care settings.Trial registration numberNCT03275311; Pre-results.
Determinants of BCG vaccination coverage in Ethiopia: a cross-sectional survey
Authors: Tsehay Asmamaw Ketemaw , Worku Getasew Tadesse , Alemu Yihun Mulugeta 
Published: February 2019

ObjectiveThe objective of this study is to assess the determinants of BCG vaccination in Ethiopia from 2016 Ethiopia Demographic and Health Survey (EDHS).SettingSince Ethiopia has nine regional states and two administrative cities, sample was taken from all the divisions. The population-based sample was intended to provide estimates of key indicators for the country.ParticipantThe sampling frame used for the 2016 EDHS is the Ethiopia Population and Housing Census. From 15 683 women recorded in EDHS dataset, women with no child (n=10 379) were excluded from the study. Therefore, the total sample size for this study was 5304 women. The outcome variable was BCG immunisation status of children.ResultOut of the study participants (n=5304), the majority were in between 20 and 34 years of age (73.8%). The median age of the respondents was 28.4 (SD=±6.5) years old. Prevalence of BCG vaccination was 63.6% (n=3373) and BCG vaccination coverage in urban residents was higher (88%) than rural residents (57.3%). Mothers’ age between 20 up to 34 (Adjusted odds ratio (AOR)=1.48; 95% CI: 1.13 to 1.93) and between 35 up to 49 (AOR=1.83; 95% CI: 1.35 to 2.46) were more likely to vaccinate their child’s than those mothers’ age less than 20. Mothers settled in urban areas were two times more likely to vaccinate their child’s than those living in rural areas (AOR=1.94; 95% CI: 1.45 to 2.60). Mothers with greater antenatal visits show higher BCG vaccination, Antenatal Care (ANC) 4 and above (AOR=3.48; 95% CI: 2.91 to 4.15). BCG vaccination is higher for mothers delivered at non-governmental organisation health facility than home (AOR=2.9; 95% CI: 1.69 to 4.96). Maternal occupation and wealth index also had a significant association with BCG vaccination.ConclusionBCG vaccination coverage, in this study, was lower and determinant factors for BCG vaccination were residence, mother’s age, place of delivery, mother’s antenatal visit, wealth index and mother’s occupation.