bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criterion Validity, Reliability, and Usefulness of a Judo-Specific Maximal Aerobic Power Test
Authors: Shiroma Seihati A. , Julio Ursula F. , Franchini Emerson 
Published: January 2019

Purpose: To evaluate criterion validity, reliability, and usefulness of a test to measure maximal aerobic power using judo-specific movements (uchi-komi test [UKtest]). Methods: A total of 12 judokas performed 5 graded exercise tests (GETs) in 4 sessions. In sessions 1 and 2, upper-body (UBtest), lower-body (LBtest), and familiarization UKtest were performed. GETs were randomly performed and separated by at least 48 h. In sessions 3 and 4, test and retest UKtest were performed (7 d apart). For all GETs, peak oxygen consumption (), maximal heart rate (HRmax), peak blood lactate concentration [Lapeak], maximal aerobic intensity, and rating of perceived exertion (RPE) were determined. Another group of 12 judokas performed the UKtest and 1 confirmation test (20 min after the UKtest) at 105% of maximal aerobic speed until exhaustion to confirm whether maximal responses were achieved. Results: did not differ (P > .05) between UKtest (46.04 [5.34] mL·kg−1·min−1) and LBtest (44.78 [5.98] mL·kg−1·min−1), but it was higher (P < .05) than UBtest (37.03 [7.16] mL·kg−1·min−1). Total duration (551 [60] s) and [Lapeak] (7.10 [1.76] mmol·L−1) in the UKtest were different (P < .05) from UBtest (416 [47] s, 9.93 [2.15] mmol·L−1, respectively) and LBtest (433 [54] s, 10.29 [2.23] mmol·L−1, respectively). Very large relationships between in UKtest with UBtest (r = .78; P = .003) and LBtest (r = .87; P < .001) were found. Maximal values were achieved for the UKtest , HRmax, [Lapeak], RPE, and maximal aerobic speed, with no difference between test and retest (P > .05). In addition, very large intraclass correlation coefficients (ICC) for (ICC = .86), HRmax (ICC = .90), and maximal aerobic speed (ICC = .81) were found. Conclusion: The UKtest can be considered a valid, reliable, and useful test to measure maximal aerobic power using judo-specific movements.
Normative Peak 30-Min Cadence (Steps per Minute) Values for Older Adults: NHANES 2005–2006
Authors: Aguiar Elroy J. , Schuna John M. , Barreira Tiago V. , Mire Emily F. , Broyles Stephanie T. , Katzmarzyk Peter T. , Johnson William D. , Tudor-Locke Catrine 
Published: January 2019

Walking cadence (steps per minute) is associated with the intensity of ambulatory behavior. This analysis provides normative values for peak 30-min cadence, an indicator of “natural best effort” during free-living behavior. A sample of 1,196 older adults (aged from 60 to 85+) with accelerometer data from the National Health and Nutrition Examination Survey 2005–2006 was used. Peak 30-min cadence was calculated for each individual. Quintile-defined values were computed, stratified by sex and age groups. Smoothed sex-specific centile curves across the age span were fitted using the LMS method. Peak 30-min cadence generally trended lower as age increased. The uppermost quintile value was >85 steps/min (men: 60–64 years), and the lowermost quintile value was <22 steps/min (women: 85+). The highest 95th centile value was 103 steps/min (men: 64–70 years), and the lowest 5th centile value was 15 steps/min (women: 85+). These normative values may be useful for evaluating older adults’ “natural best effort” during free-living ambulatory behavior.
Effectiveness of Simulated Horseback Riding for Patients With Chronic Low Back Pain: A Randomized Controlled Trial
Authors: Kim TaeYeong , Lee JaeHyuk , Oh SeJun , Kim Seungmin , Yoon BumChul 
Published: January 2019

Context: A simulated horseback riding (SHR) exercise is effective for improvement of pain and functional disability, but its comparative effectiveness with the other is unknown. Objective: The authors aimed to demonstrate the effect of a SHR exercise in people with chronic low back pain. Design: A randomized controlled trial. Settings: Community and university campus. Participants: A total of 48 participants with chronic low back pain were divided into 2 groups, and SHR exercises (n = 24) or stabilization (STB) exercises (n = 24) were performed. Interventions: The exercises were performed for 30 minutes, 2 days per week for 8 weeks. Main Outcome Measures: Numeric rating scale, functional disabilities (Oswestry disability index and Roland–Morris disability), and fear-avoidance beliefs questionnaire (FABQ) scores were measured at baseline and at 4 weeks, 8 weeks, and 6 months. Results: A 2-way repeated analysis of variance identified that between-group comparisons showed significant differences in the FABQ related to work scale (F = 21.422; P = .01). There were no significant differences in the numeric rating scale (F = 1.696; P = .21), Oswestry disability index (F = 1.848; P = .20), Roland–Morris disability (F = 0.069; P = .80), and FABQ related to physical scale (F = 1.579; P = .24). In within-group comparisons, both groups presented significant differences in numeric rating scale (both SHR and STB after 4 wk), Oswestry disability index (both SHR and STB after 6 mo), and Roland–Morris disability (SHR after 6 mo and STB after 8 wk) compared with baseline values. In FABQ-related physical (SHR after 4 wk) and work scales (SHR after 6 mo), there were only significant differences in the SHR compared with baseline values. Conclusions: SHR exercise for 8 weeks had a greater effect than STB exercise for reducing work-related FABQ. The SHR exercise performed in a seated position could substantially decrease pain-related fear disability in young adults with chronic low back pain.
A resistivity-based approach to determining the rates of groundwater seepage into buffer materials
Authors: Ishii T. , Kawakubo M. , Asano H. , Kobayashi I. , Sellin P. , Luterkort D. , Eriksson P. 
Published: January 2019

Abstract
Bentonite-based buffer materials play an important safety role in engineered barriers planned for use in geological disposal repositories for radioactive high-level waste (HLW) in Japan. The effectiveness of buffer materials is dependent on the status of groundwater saturation during resaturation of the repository. Accordingly, it is important to determine the behaviour of buffer materials during saturation and predict post-saturation conditions such as the distribution of residual dry density and chemical alteration.
In this study, the rate of groundwater uptake into a buffer material was determined to clarify the behaviour of the material during the saturation process. As mechanical changes and chemical alteration of buffer materials are generated by groundwater permeation, knowledge of the water uptake rate is necessary for the prediction of post-permeation conditions. In the experiment reported here, one-dimensional permeation by distilled water and a NaCl water solution at a constant rate was monitored over a period of more than seven years. The results indicated that the seepage and saturation front moved in proportion to the square root of the seepage time. The coefficient of the relationships between the seepage and the saturation fronts with time of the reference bentonite used in Japan was determined.
Site screening of clay formations in NW China as host rocks for a high-level radioactive waste disposal repository
Authors: Liu Xiaodong , Liu Pinghui , Dai Chaocheng , Liu Shuai , Deng Juzhi , Zhang Weimin , Yu Zheng 
Published: January 2019

Abstract

Deep geological disposal of high-level radioactive waste (HLW) in a repository with a system of engineered and natural barriers has been recognized as an appropriate disposal concept by Chinese authorities since 2003, and both crystalline rocks and argillaceous rocks are considered as the candidate host rocks for HLW disposal repository. The 1:200 000 regional survey indicated that there are potential clay formations in Mesozoic–Cenozoic sedimentary basins in NW China. Five candidate areas have been suggested with potential clay formations including the Tamusu and Suhongtu areas with upper K
1
Bayingebi clay formations in the east Bayingebi Basin, in the Inner Mongolia Autonomous Region. On the basis of a detailed ground geological, hydrological and geophysical surveys, two test boreholes drilled to a depth of 800 m in the Tamusu area revealed that there are three lacustrine-facies clay formations (K
1
b
2-3
, K
1
b
2-2
and K
1
b
2-1
). The thickness of the K
1
b
2-3
and K
1
b
2-2
clay formations is about 300–600 m with sandstone and siltstone interbeds, while the thickness of the K
1
b
2-1
homogeneous clay formation is more than 200 m with the depth of 450 m below the surface. The spatial extension of the clay formations could meet the fundamental criteria to ensure the long-term safety of the repository. Initial mineralogical studies on core samples indicated that the mineral assemblage is dominated by analcite, kaolinite, illite and dolomite. The homogeneous argillaceous rocks rich in analcite in Tamusu area could be a new type of host rock for a HLW disposal repository.
Topographical plots of esophageal distension and contraction: effects of posture on esophageal peristalsis and bolus transport
Authors: Zifan Ali , Song Hyun Joo , Youn Young-Hoon , Qiu Xinhuan , Ledgerwood-Lee Melissa , Mittal Ravinder K. 
Published: January 2019

Each swallow induces a wave of inhibition followed by contraction in the esophagus. Unlike contraction, which can easily be measured in humans using high-resolution manometry (HRM), inhibition is difficult to measure. Luminal distension is a surrogate of the esophageal inhibition. The aim of this study was to determine the effect of posture on the temporal and quantitative relationship between distension and contraction along the entire length of the esophagus in normal healthy subjects by using concurrent HRM, HRM impedance (HRMZ), and intraluminal ultrasound (US). Studies were conducted in 15 normal healthy subjects in the supine and Trendelenburg positions. Both manual and automated methods were used to extract quantitative pressure and impedance-derived features from the HRMZ recordings. Topographical plots of distension and contraction were visualized along the entire length of the esophagus. Distension was also measured from the US images during 10-ml swallows at 5 cm above the lower esophageal sphincter. Each swallow was associated with luminal distension followed by contraction, both of which traversed the esophagus in a sequential/peristaltic fashion. Luminal distension (US) and esophageal contraction amplitude were greater in the Trendelenburg compared with the supine position. Length of esophageal breaks (in the transition zone) were reduced in the Trendelenburg position. Change in posture altered the temporal relationship between distension and contraction, and bolus traveled closer to the esophageal contraction in the Trendelenburg position. Topographical contraction-distension plots derived from HRMZ recordings is a novel way to visualize esophageal peristalsis. Future studies should investigate if abnormalities of esophageal distension are the cause of functional dysphagia. NEW & NOTEWORTHY Ascending contraction and descending inhibition are two important components of peristalsis. High-resolution manometry only measures the contraction phase of peristalsis. We measured esophageal distension from intraluminal impedance recordings and developed novel contraction-distension topographical plots to prove that similar to contraction, distension also travels in a peristaltic fashion. Change in posture from the supine to the Trendelenburg position also increased the amplitude of esophageal distension and contraction and altered the temporal relationship between distension and contraction.
Accumulation of intramyocyte TRPV1-mediated calcium during heat stress is inhibited by concomitant muscle contractions
Authors: Ikegami Ryo , Eshima Hiroaki , Mashio Takuro , Ishiguro Tomosada , Hoshino Daisuke , Poole David C. , Kano Yutaka 
Published: January 2019

Heat stress promotes intramyocyte calcium concentration ([Ca2+]i) accumulation via transient receptor potential vanilloid 1 (TRPV1) channels. We tested the hypothesis that muscle contractile activity concomitant with heat stress would accelerate the increase in [Ca2+]ivia TRPV1, further impairing [Ca2+]ihomeostasis. Spinotrapezius muscles of adult Wistar rats were exteriorized in vivo and loaded with the fluorescent Ca2+probe fura 2-AM. Heat stress (muscle surface temperature 40°C) was used as TRPV1 activator. An isometric contraction (100 Hz, 5–10 V, 30 s) was induced electrically concomitant with heat stress. [Ca2+]iwas determined for 20 min using in vivo fluorescence microscopy, and the phosphorylation response of TRPV1 was determined by Western blotting. Heat stress induced a significant [Ca2+]iincrease of 18.5 ± 8.1% at 20 min and TRPV1 phosphorylation (+231%), which was inhibited by addition of the TRPV1 inhibitor (capsazepine). However, contrary to expectations, the heat stress and isometric contraction condition almost completely inhibited TRPV1 phosphorylation and the consequent [Ca2+]ielevation (<2.8% accumulation during heat stress, P > 0.05). In conclusion, this in vivo physiological model demonstrated that isometric muscle contraction(s) can suppress the phosphorylation response of TRPV1 and maintain [Ca2+]ihomeostasis during heat stress.NEW & NOTEWORTHY This investigation is the first document the dynamics of intramyocyte calcium concentration ([Ca2+]i) increase in the myoplasm of skeletal muscle fibers in response to heat stress where the muscle blood flow is preserved. Heat stress at 40°C drives a myoplasmic [Ca2+]iaccumulation in concert with transient receptor potential vanilloid 1 (TRPV1) phosphorylation. However, muscle contraction caused TRPV1 channel deactivation by dephosphorylation of TRPV1. TRPV1 inactivation via isometric contraction(s) permits maintenance of [Ca2+]ihomeostasis even under high imposed muscle temperature.
Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture
Authors: Šimunič Boštjan , Koren Katja , Rittweger Jörn , Lazzer Stefano , Reggiani Carlo , Rejc Enrico , Pišot Rado , Narici Marco , Degens Hans 
Published: January 2019

In young and older people, skeletal muscle mass is reduced after as little as 7 days of disuse. The declines in muscle mass after such short periods are of high clinical relevance, particularly in older people who show a higher atrophy rate and a slower or even a complete lack of muscle mass recovery after disuse. Ten men (24.3 yr; SD 2.6) underwent 35 days of 6° head-down tilt bed rest, followed by 30 days of recovery. During bed rest, a neutral energy balance was maintained, with three weekly passive physiotherapy sessions to minimize muscle soreness and joint stiffness. All measurements were performed in a hospital at days 1–10, 16, 28, and 35 of bed rest (BR1–BR10, BR16, BR28, and BR35, respectively) and days 1, 3, and 30 after reambulation (R + 1, R + 3, and R + 30, respectively). Vastus medialis obliquus (VMO), vastus medialis longus (VML), and biceps femoris (BF) thickness (d) and pennation angle (Θ) were assessed by ultrasonography, whereas twitch muscle belly displacement (Dm) and contraction time (Tc) were assessed with tensiomyography (TMG). After bed rest, d and Θ decreased by 13–17% in all muscles ( P < 0.001) and had recovered at R + 30. Dm was increased by 42.3–84.4% ( P < 0.001) at BR35 and preceded the decrease in d by 7, 5, and 3 days in VMO, VML, and BF, respectively. Tc increased only in BF (32.1%; P < 0.001) and was not recovered at R + 30. TMG can detect early bed-rest-induced changes in muscle with higher sensitivity before overt architectural changes, and atrophy can be detected. NEW & NOTEWORTHY Detection of early atrophic processes and irreversible adaptation to disuse are of high clinical relevance. With the use of tensiomyography (TMG), we detected early atrophic processes before overt architectural changes, and atrophy can be detected using imaging technique. Furthermore, TMG detected irreversible changes of biceps femoris contraction time.
Quadriceps miR-542-3p and -5p are elevated in COPD and reduce function by inhibiting ribosomal and protein synthesis
Authors: Farre-Garros Roser , Lee Jen Y. , Natanek S. Amanda , Connolly Martin , Sayer Avan A. , Patel Harnish , Cooper Cyrus , Polkey Michael I. , Kemp Paul R. 
Published: January 2019

Reduced physical performance reduces quality of life in patients with chronic obstructive pulmonary disease (COPD). Impaired physical performance is, in part, a consequence of reduced muscle mass and function, which is accompanied by mitochondrial dysfunction. We recently showed that miR-542-3p and miR-542-5p were elevated in a small cohort of COPD patients and more markedly in critical care patients. In mice, these microRNAs (miRNAs) promoted mitochondrial dysfunction suggesting that they would affect physical performance in patients with COPD, but we did not explore the association of these miRNAs with disease severity or physical performance further. We therefore quantified miR-542-3p/5p and mitochondrial rRNA expression in RNA extracted from quadriceps muscle of patients with COPD and determined their association with physical performance. As miR-542-3p inhibits ribosomal protein synthesis its ability to inhibit protein synthesis was also determined in vitro. Both miR-542-3p expression and -5p expression were elevated in patients with COPD (5-fold P < 0.001) and the degree of elevation associated with impaired lung function (transfer capacity of the lung for CO in % and forced expiratory volume in 1 s in %) and physical performance (6-min walk distance in %). In COPD patients, the ratio of 12S rRNA to 16S rRNA was suppressed suggesting mitochondrial ribosomal stress and mitochondrial dysfunction and miR-542-3p/5p expression was inversely associated with mitochondrial gene expression and positively associated with p53 activity. miR-542-3p suppressed RPS23 expression and maximal protein synthesis in vitro. Our data show that miR-542-3p and -5p expression is elevated in COPD patients and may suppress physical performance at least in part by inhibiting mitochondrial and cytoplasmic ribosome synthesis and suppressing protein synthesis. NEW & NOTEWORTHY miR-542-3p and -5p are elevated in the quadriceps muscle of patients with chronic obstructive pulmonary disease (COPD) in proportion to the severity of their lung disease. These microRNAs inhibit mitochondrial and cytoplasmic protein synthesis suggesting that they contribute to impaired exercise performance in COPD.
Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment
Authors: Donovan Graham M. , Elliot John G. , Boser Stacey R , Green Francis H. Y. , James Alan L. , Noble Peter B. 
Published: January 2019

Bronchial thermoplasty is a recent treatment for asthma in which ablative thermal energy is delivered to specific large airways according to clinical guidelines. Therefore, current practice is effectively “blind,” as it is not informed by patient-specific data. The present study seeks to establish whether a patient-specific approach based on structural or functional patient data can improve outcomes and/or reduce the number of procedures required for clinical efficacy. We employed a combination of extensive human lung specimens and novel computational methods to predict bronchial thermoplasty outcomes guided by structural or functional data compared with current clinical practice. Response to bronchial thermoplasty was determined from changes in airway responses to strong bronchoconstrictor simulations and flow heterogeneity after one or three simulated thermoplasty procedures. Structure-guided treatment showed significant improvement over current unguided clinical practice, with a single session of structure-guided treatment producing improvements comparable with three sessions of unguided treatment. In comparison, function-guided treatment did not produce a significant improvement over current practice. Structure-guided targeting of bronchial thermoplasty is a promising avenue for improving therapy and reinforces the need for advanced imaging technologies. The functional imaging-guided approach is predicted to be less effective presently, and we make recommendations on how this approach could be improved. NEW & NOTEWORTHY Bronchial thermoplasty is a recent treatment for asthma in which thermal energy is delivered via bronchoscope to specific airways in an effort to directly target airway smooth muscle. Current practice involves the treatment of a standard set of airways, unguided by patient-specific data. We consider the potential for guided treatments, either by functional or structural data from the lung, and show that treatment guided by structural data has the potential to improve clinical practice.
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Authors: Doron Hila , Pukrop Tobias , Erez Neta 
Published: January 2019

AbstractBrain metastases are more common than primary CNS tumors and confer grave prognosis on patients, as existing treatments have very limited efficacy. The tumor microenvironment has a central role in facilitating tumorigenesis and metastasis. In recent years, there has been much progress in our understanding of the functional role of the brain metastatic microenvironment. In this review, we discuss the latest advances in brain metastasis research, with special emphasis on the role of the brain microenvironment and neuroinflammation, integrating insights from comparable findings in neuropathologies and primary CNS tumors. In addition, we overview findings on the formation of a hospitable metastatic niche and point out the major gaps in knowledge toward developing new therapeutics that will cotarget the stromal compartment in an effort to improve the treatment and prevention of brain metastases.
First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors
Authors: Shimomura Akihiko , Yamamoto Noboru , Kondo Shunsuke , Fujiwara Yutaka , Suzuki Shigenobu , Yanagitani Noriko , Horiike Atsushi , Kitazono Satoru , Ohyanagi Fumiyoshi , Doi Toshihiko , Kuboki Yasutoshi , Kawazoe Akihito , Shitara Kohei , Ohno Izumi , Banerji Udai , Sundar Raghav , Ohkubo Shuichi , Calleja Elizabeth M. , Nishio Makoto 
Published: January 2019

Abstract
HSP90 is involved in stability and function of cancer-related proteins. This study was conducted to define the MTD, safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor efficacy of TAS-116, a novel class, orally available, highly selective inhibitor of HSP90. Patients with advanced solid tumors received TAS-116 orally once daily (QD, step 1) or every other day (QOD, step 2) in 21-day cycles. Each step comprised a dose escalation phase to determine MTD and an expansion phase at the MTD. In the dose escalation phase, an accelerated dose-titration design and a “3+3” design were used. Sixty-one patients were enrolled in Japan and the United Kingdom. MTD was determined to be 107.5 mg/m2/day for QD, and 210.7 mg/m2/day for QOD. In the expansion phase of step 1, TAS-116 was administered 5 days on/2 days off per week (QD × 5). The most common treatment-related adverse events included gastrointestinal disorders, creatinine increases, AST increases, ALT increases, and eye disorders. Eye disorders have been reported with HSP90 inhibitors; however, those observed with TAS-116 in the expansion phases were limited to grade 1. The systemic exposure of TAS-116 increased dose-proportionally with QD and QOD regimens. Two patients with non–small cell lung cancer and one patient with gastrointestinal stromal tumor (GIST) achieved a confirmed partial response. TAS-116 had an acceptable safety profile with some antitumor activity, supporting further development of this HSP90 inhibitor.
This is a result from a first-in-human study, in which the HSP90 inhibitor TAS-116 demonstrated preliminary antitumor efficacy in patients with advanced solid tumors, including those with heavily pretreated GIST.