bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity
Authors: Calvayrac Olivier , Nowosad Ada , Cabantous Stéphanie , Lin Lin‐Po , Figarol Sarah , Jeannot Pauline , Serres Murielle P , Callot Caroline , Perchey Renaud T , Creff Justine , Taranchon‐Clermont Estelle , Rouquette Isabelle , Favre Gilles , Pradines Anne , Manenti Stephane , Mazieres Julien , Lee Huei , Besson Arnaud 
Published: September 2018

AbstractThe cell cycle inhibitor p27Kip1 is a tumor suppressor via the inhibition of CDK complexes in the nucleus. However, p27 also plays other functions in the cell and may acquire oncogenic roles when located in the cytoplasm. Activation of oncogenic pathways such as Ras or PI3K/AKT causes the relocalization of p27 in the cytoplasm, where it can promote tumorigenesis by unclear mechanisms. Here, we investigated how cytoplasmic p27 participates in the development of non‐small cell lung carcinomas. We provide molecular and genetic evidence that the oncogenic role of p27 is mediated, at least in part, by binding to and inhibiting the GTPase RhoB, which normally acts as a tumor suppressor in the lung. Genetically modified mice revealed that RhoB expression is preferentially lost in tumors in which p27 is absent and maintained in tumors expressing wild‐type p27 or p27CK–, a mutant that cannot inhibit CDKs. Moreover, although the absence of RhoB promoted tumorigenesis in p27−/− animals, it had no effect in p27CK– knock‐in mice, suggesting that cytoplasmic p27 may act as an oncogene, at least in part, by inhibiting the activity of RhoB. Finally, in a cohort of lung cancer patients, we identified a subset of tumors harboring cytoplasmic p27 in which RhoB expression is maintained and these characteristics were strongly associated with decreased patient survival. Thus, monitoring p27 localization and RhoB levels in non‐small cell lung carcinoma patients appears to be a powerful prognostic marker for these tumors. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Urine biochemistry to predict long‐term outcomes in fetuses with posterior urethral valves
Authors: Dreux Sophie , Rosenblatt Jonathan , Moussy‐Durandy Amélie , Patin Franck , Favre Romain , Lortat‐Jacob Stephen , El Ghoneimi Alaa , Oury Jean‐François , Deschenes Georges , Ville Yves , Heidet Laurence , Muller Francoise 
Published: September 2018

What's already known about this topic?

In fetuses with lower urinary tract obstruction, prenatal counseling with regard to long‐term renal function is an unmet challenge. The literature on the predictive value of fetal urine analysis is controversial.
What does this study add?

In a cohort of 89 children affected by posterior urethral valves, and who reached 10 years of age, multivariate analysis of fetal urinary markers predicted renal function with 93% sensitivity and 71% specificity.
Ultrathin Fe‐N‐C Nanosheets Coordinated Fe‐Doped CoNi Alloy Nanoparticles for Electrochemical Water Splitting
Authors: Zhang Qingran , Webster Richard F. , Cheong Soshan , Tilley Richard D. , Lu Xunyu , Amal Rose 
Published: September 2018

AbstractThe development of highly active and cost‐effective catalyst materials toward electrochemical water splitting is of great importance for converting and storing the intermittent solar energy in the form of hydrogen. Herein, for the first time, an ultrathin Fe and N‐co‐doped carbon nanosheet encapsulated Fe‐doped CoNi alloy nanoparticle (FeCoNi@FeNC) composite is obtained and applied as a bifunctional catalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). This catalyst exhibits prominent catalytic performances for both HER and OER, which only requires overpotentials of 102 and 330 mV, respectively, to reach a current density of 10 mA cm−2 in alkaline media. The high catalytic activity is intrinsically associated with the presence of Fe in both nanosheets and nanoparticles, which has triggered the occurrence of coordinative effects between Fe‐N‐C and FeCoNi that are beneficial for HER and OER, as revealed by electrochemical techniques. In an overall water splitting electrolyzer, FeCoNi@FeNC is employed as both the cathode and anode catalysts, achieving 12 mA cm−2 at 1.63 V for a duration of more than 12 h.
Don’t Start with Europeans First. An Initiative for Extending Voting Rights Should also Promote Access to Citizenship for Third Country Nationals
Authors: Swoboda Hannes 
Published: September 2018

AbstractI would support the idea of a citizens’ initiative proposing the extension to EU citizens of the right to vote in national elections in the member state of residence. At the same time, I do not share the view that we should ‘start with the Europeans first’. EU policy makers should encourage member states to facilitate access to national citizenship for third country nationals who are long term residents in a member state.
EU Citizens Should Have Voting Rights in National Elections, But in Which Country?
Authors: Bauböck Rainer 
Published: September 2018

AbstractI will be happy if Philippe Cayla’s and Catriona Seth’s proposal for a European Citizens’ Initiative (ECI) on national voting rights for EU citizens is successful. But I will not sign it myself. I agree that there is a serious democratic deficit in the current regulation of voting rights. It is contrary to the spirit of EU law if EU citizens who take up residence in another member state lose fundamental rights as a consequence of exercising their right of free movement. And it seems particularly perverse that they retain their rights to vote in local and European Parliament elections but can lose the more significant franchise in national elections. The question is: which country should be responsible for letting them vote and under which conditions?
‘Feed them First, Then Ask Virtue of Them’: Broadening and Deepening Freedom of Movement
Authors: Sangiovanni Andrea 
Published: September 2018

AbstractGiven Ferrera’s insistence that EU citizenship should play a more ‘integrative role’, the criteria by which we should judge whether his proposals would be successful, assuming they were ever adopted, are explicitly functional. In my contribution I seek to ground them not in a functional-empirical analysis of what is most likely to inspire support for EU citizenship but in a broader conception of social justice. The two perspectives are not in direct competition, but they do depart from very different starting points.
EU Citizenship, Duties and Social Rights
Authors: Seeleib-Kaiser Martin 
Published: September 2018

AbstractEU migrant citizens are often considered as outsiders, who access social benefits and services without having fulfilled their duties in the country of destination. As a group, however, EU migrant citizens are net contributors to the public purse in key destination countries. The current debate on duties of citizens within (con)federal jurisdictions has been rehearsed in different contexts, such as the North German Federation or the US, and the arguments are no different. EU citizenship must become an unconditional fundamental status, if it is to be meaningful.
Imagine: European Union Social Citizenship and Post-Marshallian Rights and Duties
Authors: Kostakopoulou Dora 
Published: September 2018

AbstractWriting in 1959, Ortega y Gasset noted that ‘reality is not closed and reduced to the past and the present, but holds open the frontier of the future in which the real will be something that has yet to come into being.’ Ferrera and the other contributors in this forum have opened up a debate on the future of EU citizenship and argued for its ‘renovation’ in the light of rising Euroscepticism and nationalist centrifugalism in the member states. Ferrera shares Bauböck’s diagnosis that EU citizenship has not met its integrative potential. While renovation is not always innovation, Ferrera has laid down the path for innovative thinking about the (future) content of EU citizenship and for the introduction of ‘soft’ citizenship duties which would strengthen the ties that bind EU citizens. I am in favour of ‘soft’ as well as ‘hard’ EU citizenship duties and I argue here that EU citizenship is not, and cannot be, duty free.
How to Enfranchise Second Country Nationals? Test the Options for Best Fit, Easiest Adoption and Lowest Costs
Authors: Owen David 
Published: September 2018

AbstractThe proposal of this ECI by Philippe Cayla and Catriona Seth is a welcome initiative addressing a problem that has already been highlighted by the European Commission, namely, that some ‘second country nationals’ (SCNs) lose their entitlement to vote in the national elections of their state of nationality without having acquired the right to vote at this level in their state of residence. This chapter critically considers a number of possible rules for resolving the legitimacy deficit identified. It tests them against three criteria: best fit, easiest adoption and lowest costs.
What’s in a People? Social Facts, Individual Choice, and the European Union
Authors: Kochenov Dimitry 
Published: September 2018

AbstractRainer Bauböck’s contribution struggles hard with a non-existing problem ignoring the fact that those who have little interest in the state of residence would obviously find it nonsensical to participate in the political life there. Knowing this leaves open the question whether it is worth superimposing the people’s judgment with a state-mandated one. If people are free, societal ties cannot depend on state mandated blessings.
Cash-for-Passports and the End of Citizenship
Authors: Spiro Peter J. 
Published: September 2018

AbstractInvestor citizenship programmes are becoming increasingly commonplace in state practice. What was once the province of outlier Caribbean microstates is gaining traction among more substantial states. Cash-for-passports, as Ayelet Shachar labels the phenomenon, clashes with our received understandings of citizenship as a marker of social solidarity in a Walzerian sense. The emerging market for citizenship literally commodifies the status.But where Shachar sees investor citizenship programmes as a threat to robust citizenship ties, I see them more as a manifestation of citizenship that is already being hollowed out. In the old world, investor citizenship programmes would have been inconceivable.Today, far from inconceivable, they are becoming an accepted element of strategic immigration policy.
Don’t Put the Baby in the Dirty Bathwater! A Rejoinder
Authors: Dumbrava Costica 
Published: September 2018

AbstractIt is beyond dispute that any attempt to dislodge a deeply rooted and widespread institution such as ius sanguinis is bound to pose serious practical challenges. However, if one has compelling moral reasons for dismantling such an institution, one ought to work towards this end. Babies are born into a physical world and from actual bodies but they are not naturally born into families and citizenship. The latter are social conventions that demand our acceptance when they are justified and our courage to change and replace them when they are not. To my critics who worried that abolishing ius sanguinis amounts to throwing out the baby with the dirty bathwater I reply that we should not put the baby in the dirty bathwater in the first place.
Revocation of Citizenship of Terrorists: A Matter of Political Expediency
Authors: Hailbronner Kay 
Published: September 2018

AbstractRevocation of citizenship means a substantial interference with individual rights. It can only be justified if tightly defined material conditions in accordance with the constitutional law of each country and its international commitments are fulfilled. Risk assessment and proof of an affiliation, assistance or membership in an international terrorist organisation will be essential elements in this procedure. Whether there is a practical value in revocation of citizenship for citizens engaged in international terrorism in addition to criminal and administrative sanctions is within the framework of law a matter of political expediency which may well lead to different results in different countries.
Human Rights for All Is Better than Citizenship Rights for Some
Authors: Kanstroom Daniel 
Published: September 2018

AbstractThe best way to avoid The calamities of the rightless for whom no law exists (Arendt) is not only to strengthen citizenship protections. That may well have the perverse consequences of, on the one hand, rendering citizenship ever harder to achieve, and on the other, relegating noncitizens to an increasingly rightless realm. We must do the harder, more basic work of defining and instantiating meaningful human rights protections for all people, regardless of status, or location. Focusing too specifically on the problem of deprivation of citizenship must not blind us ‘to the numerous small and not so small evils with which the road to hell is paved.’
Virtual Politics, Real Guns: On Cloud Community, Violence, and Human Rights
Authors: Blake Michael 
Published: September 2018

AbstractMy contribution does not intend not to defeat Orgad’s vision, but to outline significant worries about how we might make that vision real. Orgad does not want voluntary forms of transnational institution to take the place of states, but insists upon their validity and power as ‘state-like entities.’ It is this latter point with which I take issue. If these institutions are to become genuinely state-like, they must have some part in doing what it is that states do; and we must understand how they could do that sort of thing, and how we could move from where we are to where we might be. If, in contrast, these institutions are merely places for debate and for the creation of solidarity, then we have had them for a very long time indeed. It is then not clear what these tools provide us with except for scale and ease. Either way, I suggest, we have some work to do. Orgad’s vision is profoundly hopeful, while my own is not, and I genuinely hope I can be proven wrong.
Cloud Agoras: When Blockchain Technology Meets Arendt’s Virtual Public Spaces
Authors: Kostakopoulou Dora 
Published: September 2018

AbstractThe virtual public space of blockchain communities will make citizens think, engage and act more virtually. In other words, the virtual reality of cloud agoras will have an impact on institutions and the participants themselves; it will yield pressures for more open, transparent and accountable institutions and will result in more virtuous, that is, actively engaged, citizens. Whether cloud agoras will prove to be decisive public spaces and strong promoters of democratic processes that make wealth, power and privilege accountable or merely subaltern counter publics will depend on the intentions and actions of their participants. In other words, the answer to the question whether the virtual public space of global citizenship will have a decisive influence on global, regional and national public policy-making is not theoretical or scholarly; it will be a contextual one.
Reducing Healthcare Costs Using ACS NSQIP‐Driven Quality Improvement Projects: A Success Story from Sheikh Khalifa Medical City (SKMC)
Authors: Nimeri Abdelrahman A. , Bautista Jejomar , Philip Ruby 
Published: September 2018

AbstractIntroductionSurgical complications increase hospital length of stay and costs and lead to poor patient experience. We aim to evaluate our complication rates over time and the financial impact of joining the adult multi‐specialty American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) at Sheikh Khalifa Medical City (SKMC).MethodsSheikh Khalifa Medical City is a Joint Commission International‐accredited ACS NSQIP member since 2009. For the purpose of quality improvement, we have established several task forces (2010–2014) to decrease high rates of venous thromboembolism (VTE), urinary tract infection (UTI), surgical site infection (SSI), unplanned intubation (UI), and ventilator more than 48 h (Vent > 48 h). Our aim is to evaluate our complication rates over time and calculate the cost savings from prevented occurrences in VTE, UTI, SSI, UI, and Vent > 48 h. Cost savings are calculated using the return on investment calculator from ACS NSQIP. In addition, the cost of joining and maintaining ACS NSQIP at SKMC is calculated to determine the total cost savings after subtracting these costs.ResultsDuring the study period, we performed 8842 cases (2009–2015) and our overall morbidity improved significantly from observed/expected (O/E) 1.61% to (O/E) 0.85%. We prevented 12 VTE cases (2011–2015), 56 UTI cases (2013–2015), 12 SSI cases (2013–2015), 4 UI cases (2014–2015), and 7 Vent > 48 h cases (2014–2015). The cost saving from all these four task forces was $1,680,000. The cost of joining and maintaining ACS NSQIP at SKMC since 2009 was $336,000. Hence, the total saving for SKMC was $1,344,000.ConclusionACS NSQIP‐driven quality improvement projects have resulted in reduction in complications and healthcare costs at SKMC over a 6‐year period.
Rainfall-Runoff Modeling using Clustering and Regression Analysis for the River Brahmaputra Basin
Authors: Mishra Satanand , Saravanan C. , Dwivedi V. K. , Shukla J. P. 
Published: September 2018

ABSTRACT
In this research, k-means, agglomerative hierarchical clustering and regression analysis have been applied in hydrological real time series in the form of patterns and models, which gives the fruitful results of data analysis, pattern discovery and forecasting of hydrological runoff of the catchment. The present study compares with the actual field data, predicted value and validation of statistical yields obtained from cluster analysis, regression analysis with ARIMA model. The seasonal autoregressive integrated moving average (SARIMA) and autoregressive integrated moving average (ARIMA) models is investigated for monthly runoff forecasting. The different parameters have been analyzed for the validation of results with casual effects. The comparison of model results obtained by K-means & AHC have very close similarities. Result of models is compared with casual effects in the same scenario and it is found that the developed model is more suitable for the runoff forecasting. The average value of R2 determined is 0.92 for eight ARIMA models. This shows more accuracy of developed ARIMA model under these processes. The developed rainfall runoff models are highly useful for water resources planning and development.
Methodological Validation for Automated Lineament Extraction by LINE Method in PCI Geomatica and MATLAB based Hough Transformation
Authors: Salui Chalantika Laha 
Published: September 2018

ABSTRACT
Spatial distribution and pattern recognition of geologic lineaments are very effective in hazard risk evaluation. To make the process automated, various algorithms with various data sources were applied. This paper aims to make a review on such algorithms as well as data sources used. Comparative analysis of the LINE algorithm in PCI Geomatica and Hough Transformation in MATLAB has been conducted to explore the procedural accuracy with reference to existing landslides in the Darjeeling Himalayan region. Another comparison was made based on data sources like Landsat-8 OLI and digital elevation model, with reference to the same. As lineament density affects the landslide occurrences predominantly, the output lineament density by these two methods as well as with ground reflection and ground elevation data, were correlated with that of the landslide inventory map. A relational illustration was also done in between the lithological thrust direction and the direction of the individual lineament outputs. Hence, this study provides a decision on the use of a reliable method and data source for the automated lineament extraction which can be considered as generating an output with higher accuracy and, hence, safer for using it in the structural planning and execution of projects on various natural hazard studies.
A Laboratory Study on Estimation of Shear Strength and Compaction Properties of Overburden Dump Material in Indian Coal Mines
Authors: Bishwal R. M. , Sen Phalguni , Jawed M. 
Published: September 2018

ABSTRACT
The study investigates the effect of various soil mixtures, mostly found in the overburden material of coal mines, on the strength parameters and compaction properties. Samples were prepared in laboratory to represent both the soil-type and the rock-type waste dump material by mixing shale, sandstone and clay in varying proportions at an interval of 10% each. Samples from two coal mines located at different geographical locations in the eastern part of India were collected and the shear strength (cohesion and friction angle) and compaction parameters (Maximum dry density, MDD and Optimum moisture content, OMC) of the specimens were determined from laboratory study at moisture content around their OMC and analysed. The results so establish that the shear strength parameters for mixtures containing shale are less sensitive to changes and follows rather a flat curve when plotted against their respective material content in the mixture when compared to that containing clay. However, the compaction parameters were found to follow different trends when plotted against the constituent material (shale, sandstone and clay) content of the mixture.
Spectral Analysis of Magnetic data in the Ajmer-Sambar Sector, North-Central Rajasthan
Authors: Kumar K. Satish , Begum S. Parveen , Srinivas G. S. , Rao M. Shri Hari , Prasad P. Prabhakara , Seshunarayna T. , Tiwari R. K. 
Published: September 2018

ABSTRACT
Ajmer-Sambar sector of Delhi fold belt, North-Central Rajasthan has got importance due to its litho characters, structure, metamorphism, magmatism, migmatisation, metallogeny and rich potential of base metal mineralization. This sector is comprised of Delhi sequence of rocks hosted by the Banded Gneisses Complex (BGC). In view of the significance of this region, ground magnetic survey was conducted along six regional profiles to understand the structural features, magnetic nature of the basement and depth to the basement. Analysis of the magnetic data has clearly identified two magnetic lineaments (a) L1 in WNW-ESE direction that appears to represent litho-contact between Kalyanpura sequences in the south to Anasagar migmatite in the north and (b) L2 in NNW to SSE direction south of Parvatsar which is inferred to be a structural control about which the quartzite rocks of Taragarh Formation culminate. An average depth to basement of 3.7 km is estimated through spectral analysis of magnetic data. The maximum depth of the basin 4.5 km is estimated in central part of the study area. The obtained depth results are in good agreement with the Cummulative Total Intensity Magnetic Anomaly field (CTIMAF) and Deep seismic stuides.