bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bringing Research Data Management to Academic Libraries
Authors: Hüser Falco Jonas , Lavanchy Paula Maria Martinez 
Published: August 2019

Modern research institutions are faced with rapidly increasing challenges imposed by data-driven science and have to deal with new demands from funding agencies and publishers regarding open access to research data as well as from the Code of Conduct for Research Integrity on reproducibility of results. In reply to these requirements, the Technical University of Denmark (DTU) has adapted a two-fold strategy of bringing together decision-makers, relevant support units in the administration and researchers from all departments for the task of designing policies and services in alignment with common traditions in the different fields of research. This mixed “bottom-up” / “top-down” approach ensures that best practices for research data management can be implemented in the daily routines of employees in a practical and supportive way while ensuring that the researchers can live up to all relevant administrative, legal and ethical standards.
In this presentation, we will show how DTU Library has taken over a central position in this process by investigating the needs and demands from researchers in the different fields, drafting procedures and guidelines for research data management and establishing support functions and training for all aspects of the data life cycle. Within this new and complex area, the creation of new positions for research data management at the library in addition to an optimal utilization of existing resources and knowledge has been crucial for building up the necessary expertise and thus for the success of the strategy.
AuthorsFalco Jonas Hüser, PhDProject Officer – Research Data Managementemail: falh@dtu.dkORCiD 0000-0001-9645-6691Paula Maria Martinez Lavanchy, PhDProject Officer – Research Data Managementemail: paml@dtu.dkORCiD 0000-0003-1448-0917
New possibilities to diagnose pulmonary tuberculosis at a pulmonology inpatient department
Authors: Borodulina E. A. , Borodulin B. E. , In’kova A. T. , Vdoushkina E. S. , Povalyayeva L. V. 
Published: August 2019

The aim of the study was to investigate new methods for pulmonary tuberculosis (TB) detection at a pulmonology inpatient department.Methods. Pulmonary TB cases (n = 49) newly diagnosed at a pulmonology department of a hospital were involved in the study; among them, 69.4% of patients were infected with human immunodeficiency virus (HIV). All patients were asked if he/she had previously contacted with other TB patients, and if he/she was diagnosed with TB previously. The patients were also about family history. Posteroanterior and lateral chest X-ray and laboratory analyses were performed in all patients. Mycobacteria tuberculosis (MBT) were searched using smear microscopy, GeneXpert MTB/RIF molecular method and culturing (BACTEC MGIT) of sputum and bronchoalveolar lavage fluid (BALF) obtained during bronchoscopy. Patients with positive results only were included in the analysis in order to investigate and to compare diagnostic value of the methods.Results. Questioning patients at admission was useful to diagnose TB in 4% of patients. Sputum smears were positive in 12 patients (27.3%). BALF was obtained in 18 patients (36.7%); among them, MBT was identified in 52 (5%). Molecular testing was positive in all 49 patients (100%); among them, BACTEC MGIT culturing yielded MBT in 48 patients (97.9%). In patients with negative sputum smears during the first 3 days after admission, GeneXpert required 10.4 ± 5.3 days.Conclusion. GeneXpert method was highly useful to diagnose TB and was comparable with BACTEC. Routine sputum and BALF smear microscopy was significantly less rapid and less sensitive method. The diagnostic accuracy could be increased with the use of molecular methods in patients with negative sputum smears obtained at a general hospital. Therefore, molecular methods could be used in patients highly suspected for TB.
A importância do bem receber no espaço público: estudo de caso da empresa RIOTUR e seu serviço de informações turísticas
Authors: Santiago Patrícia Elizabeth De Souza , Lança Viviane Soares 
Published: August 2019

A hospitalidade é primordial para o turismo e, no âmbito da cidade, se traduz na disponibilidade de serviços, estruturas e equipamentos turísticos eficientes. O visitante, por meio de sua percepção subjetiva, avalia o destino como hospitaleiro ou inospitaleiro, o que pode acarretar no seu retorno ou em uma propaganda negativa do local visitado. Entre os serviços hospitaleiros proporcionados ao turista na cidade do Rio de Janeiro está o de informações turísticas, prestado pela Empresa de Turismo do Município do Rio de Janeiro (Riotur). Nesse contexto, o objetivo deste trabalho foi apresentar a realidade da empresa em relação à qualidade e eficiência de suas informações, baseando-se em opiniões de turistas e dos próprios funcionários da empresa. Trata-se de uma pesquisa descritiva de cunho qualitativo, em que se adotou como método a investigação bibliográfica e documental, além de entrevistas semiestruturadas a turistas usuários do serviço e aos trabalhadores da empresa. Por meio da análise realizada constatouse que, apesar do serviço de informações ser bem avaliado e eficiente na visão do turista, existem lacunas e melhorias que apenas o agente de informações consegue identificar.
Turismo de base comunitária e desenvolvimento local em Unidades de Conservação: estudo de caso no Restaurante Ilha das Peças, Guaraqueçaba – PR
Authors: Betti Patricia , Frigo Denardin Valdir 
Published: August 2019

O surgimento de iniciativas de turismo de base comunitária (TBC) em Unidades de Conservação da Natureza (UCs) é expressivo. Todavia, são incipientes estudos a respeito de como se organizam e se relacionam com as UCs para promoção do desenvolvimento local. Nesse contexto, investigar formas de organização comunitária de TBC enquanto modelo alternativo de turismo em Unidades de Conservação da Natureza para o desenvolvimento local constitui-se no objetivo deste trabalho. Para tanto, realizou-se pesquisa qualitativa utilizando-se o método de estudo de caso e selecionando-se para estudo o Restaurante Ilha das Peças, inciativa de base comunitária desenvolvida por um grupo de mulheres da Vila das Peças, localizada no entorno imediato do Parque Nacional do Superagui, Guaraqueçaba/PR. Os resultados indicam que essa iniciativa contribui para a consolidação de múltiplas dimensões: social, cultural, econômica, ambiental e humana e da própria expressão da dimensão simbólica da vida em sociedade, favorecendo o desenvolvimento local, e que o TBC configura-se alternativa viável em áreas de abrangência de UCs na medida em que privilegia a organização das populações e gera diversos benefícios localmente.
Parque Estadual do Itacolomi e Atividades Físicas e Esportivas na Natureza: Estudo de um Equipamento de Lazer
Authors: Rosa Maria Cristina , Costa Francis Carvalho , Santana Jaqueline De Oliveira 
Published: August 2019

O Parque Estadual do Itacolomi (Peit), em Ouro Preto/MG, tem sido objeto de estudo de diferentes áreas, como turismo, lazer e geologia. Este trabalho buscou identificar usos do Peit pelos visitantes e o seu potencial para o desenvolvimento de atividades de lazer na natureza, especialmente as que abrangem os interesses físico-esportivos. A pesquisa de abordagem qualiquantitativa, do tipo exploratório e descritivo, teve como amostra o gerente do Peit e 39 visitantes, de ambos os sexos, e idade entre 17 a 58 anos. Foram empregados observação direta, entrevista semiestruturada e questionário. Os visitantes utilizam o Peit para contemplar a natureza, visitar o acervo histórico, realizar pesquisas e fazer atividades físicas e esportivas na natureza, sendo caminhada, corrida e mountain bike as principais, todas estas motivadas por lazer e/ou saúde. O Peit apresenta potencial para desenvolvimento de intervenções nesse âmbito devido sua estrutura e recursos naturais, assim como turistas de Ouro Preto demonstram interesse em realizar atividades na natureza, sendo essa uma condição relevante para planejar e efetivar novas ações no local, dinamizando eaumentando os seus usos bem como seu público.
Proses Pembentukan Aqidah dan Akhlak Pada Siswa Sekolah Dasar di Kota Jayapura
Authors: Efendi Didik 
Published: August 2019

Penelitian ini bertujuan untuk memperoleh gambaran proses terbentuknya aqidah dan akhlak serta faktor yang mempengaruhi keberhasilan dalam proses pembentukan aqidah dan akhlak pada siswa Sekolah Dasar (SD) di kota Jayapura. Penelitian kualitatif ini menggunakan desain studi kasus. Penelitian ini dilakukan di Sekolah Dasar Islam Terpadu (SDIT) Permata Hati kota Jayapura. Pengumpulan data dalam penelitian ini dilakukan melalui observasi, interview, dan dokumentasi. Hasil penelitian menunjukkan bahwa proses terbentuknya aqidah dan akhlak pada siswa SDIT Permata Hati melalui empat tahapan yakni (1) Receiving (menerima). Pada tahap ini guru memberikan pemahaman/ pegetahuan tentang nilai-nilai aqidah dan akhlak yang harus dimiliki, (2) Responding (menanggapi). Tahap ini siswa sudah mulai aktif dalam menanggapi apa yang diberikan oleh guru yang terkait dengan aqidah dan akhlak. (3) Acting (bertindak). Pada tahap ini siswa diberi kesempatan untuk mengaktualisasikan nilai-nilai aqidah dan akhlak yang sudah diresponnya dalam kehidupanya sehari-hari. (4) Being (menjadi seperti yang diketahui). Pada tahap ini siswa seharusnya sudah terbentuk aqidah dan akhlaknya atau bisa dikatakan sudah menjadi kebiasan (being). Sedangkan faktor pendukung keberhasilan pembentukan aqidah dan akhlak pada siswa SDIT Permati Hati diantaranya adalah peran guru dan orang tua.
Lipoprotein apheresis affects ventricular repolarization in patients with homozygous familial hypercholesterolemia
Authors: EKİZLER Firdevs Ayşenur , CAY Serkan , ACAR Burak , TAK Bahar Tekin , CETİN Elif Hande Ozcan , TEMİZHAN Ahmet 
Published: August 2019

Aim: Patients
with Homozygous Familial
Hypercholesterolemia (HoFH) prone to experience premature
cardiovascular disease and often die from sudden cardiac death (SCD) at a young
age. Lipoprotein
apheresis (LA) is the treatment of choice to prolong survival. Several
mechanisms has been suggested to be responsible for the known short and
long-term clinical benefits of this procedure. This study was conducted to
assess the effect of single LA on ventricular repolarization parameters in
patients with HoFH.Material and Methods: Eleven patients (mean
age 30.1 ± 5.5 years, male 63.6%) with HoFH on chronic LA treatment were
enrolled in this preliminary study. Double filtration plasmapheresis (DFPP) was
performed in all patients. To examine the effects of a single
session of LA, on ventricular repolarization, the OT, QTc
interval, the T peak-to-end (Tp-e) interval, Tp-e/QT and the Tp-e/QTc ratio
were specifically calculated.Results:
The single session of LA reduced total LDL (from 10.04 ± 1.91 to 4.16 ± 1.21
mmol/L, P&lt;001). The heart rate did
not change significantly after LA session. Plasma levels of
calcium and magnesium was significantly decreased after the procedure. The QTc
decreased from 443.8 ± 23.3 ms to 412.3
± 20.0 ms (P &lt;0.001). The Tp-e interval and the Tp-e/QTc ratio decreased significantly [85
(70-89) ms vs. 63 (58-71)ms; P =0.003,
and 0.19
(0.16-0.20) vs 0.15
(0.13-0.16); P =0.003, respectively].

Conclusion: Our
data suggest that even a
single session of LA improved electrocardiographic repolarization indexes.
Çocuk yoğun bakım ünitesinde akut hipoksi nedeniyle yatan hastaların yakın dönem nörolojik takibi
Authors: UYSAL YAZICI Mutlu , ÖZDEMİR Fatih M.akif , ÖZTOPRAK Ülkühan , AZAPAĞASI Ebru , EKŞİOĞLU Ayşe Seçil , AKSOY Ayşe , YÜKSEL Deniz 
Published: August 2019

Amaç: Beyin kan akımını ve
dokulara oksijen sunumunu etkileyen çeşitli durumlarda (boğulma, arrest,
asfiksi gibi) gelişebilen hipoksik iskemik beyin hasarı önemli bir morbidite ve
mortalite nedenidir. Bu çalışmanın amacı son iki yılda çocuk yoğun bakım
ünitesi'nde akut hipoksi nedeniyle yatan hastaların etyoloji, klinik
özellikler, tedavi ve yakın dönem nörolojik takip sonuçlarının
değerlendirilmesidir.Gereç ve Yöntemler: Çalışmaya
Mayıs2017- Nisan 2019 tarihleri arasında ÇYBÜ'ye yatırılan 1 ay-18 yaş arası
daha öncesinden sağlıklı , mental ve motor gelişim basamakları normal olan akut
hipoksi nedeniyle yatırılan 25 hasta
alındı.ÇYBÜ'de arrest sonrası değerlendirme için Pediatrik Serebral Performans Kategori
Skorlama Sistemi (PCPC) kullanıldı.Bulgular:Hastaların geliş Glaskow koma skalası (GKS) median:6 (min:3
max:15) iken; yoğun bakımdan çıkış GKS: 10 (min:6 max:15) olarak tespit
edildi(p&lt;0,05).. Hastaların arrest olduktan hemen sonra kan gazında asidozda
oldukları, Hco3'ün belirgin düşük olduğu,pH: (min:6.91 - max:
7.49); Laktat'ın yüksek (min:8 - max: 145); AST'nin
min:21 - max:712 ve CK'nın yüksek (min:47
- max:3351) olduğunu ve ÇYBÜ'ye yatırılıp hızlıca
uygun tedavi başlandıktan 24 saat sonra hastaların asidozdan çıktığı pH:
(min:7.23 - max:7.61); AST (min:15 - max:83) ;ALT (min:6 - max:45)ve CK (min:16 -
max:258) ve Laktat'ın (min:8 - max:93) gerilediğini gördük ve bu
sonuçlar istatiksel olarak anlamlı
saptandı.( p&lt;0,05)

Sonuç: Akut Hipoksinin patofizyolojisinin iyi anlaşılması,
erken dönemde tedavi stratejilerinin geliştirilerek beynin hasardan korunması
gereklidir.Olguların nörolojik izlemi ve yardımcı görüntüleme tetkikleri ile
hasarın ciddiyeti ve prognoz üzerine etkileri araştırılıp en uygun tedavi
yapılmalıdır. Akut hipoksiden geçen çocuklarda nörolojik sekel riskini en aza
indirmek için hastalar resusitasyon sonrası en erken dönmede ÇYBÜ'ye
yatırılmalı ve multidisipliner tedavi edilmelidir.
Efek Gastroprotektif Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Tikus Jantan yang Diinduksi Aspirin
Authors: Putri Cynthia Astiti , Pramudita Ramadani Arba , Rahma Maulida Fanny 
Published: August 2019

Obat antiinflamasi non steroid (AINS), terutama yang dapat diperoleh tanpa resep, telah banyak digunakan oleh masyarakat untuk meredakan rasa sakit dan gejala inflamasi pada penyakit yang diderita. Namun, efek samping berupa ulkus lambung yang banyak dialami oleh pengguna AINS. Penelitian ini bertujuan untuk meneliti efek ekstrak etanol daun pepaya (Carica papaya L.) pada tikus Wistar jantan yang diinduksi ulkus lambung menggunakan aspirin. Hewan uji dibagi menjadi 6 kelompok; kontrol normal (CMC 0,5%), kontrol positif (omeprazol 20 mg/kg), kontrol negatif (CMC 0,5%), kelompok perlakuan (ekstrak etanol daun pepaya dosis 100, 200, dan 300 mg/kg). Perlakuan diberikan selama 9 hari. Pada hari ke-10, semua tikus diinduksi dengan aspirin dosis 500 mg/kg kecuali kelompok normal yang dipuasakan selama 24 jam terlebih dahulu. Pada akhir penelitian, semua hewan uji dikorbankan dan lambungnya diambil untuk diukur indeks ulkus dan dibuat preparat. Tikus yang diberikan etanol ekstrak pepaya tidak terbentuk ulkus, bahkan lebih baik, dibandingkan dengan kelompok kontrol positif (p<0,05). Selain itu, hasil pembacaan histopatologi lambung menunjukkan bahwa pemberian daun pepaya dapat menjaga lambung tetap normal. Pemberian ekstrak etanol daun pepaya 100 mg/kg dapat mencegah terjadinya ulkus lambung pada tikus yang diinduksi menggunakan aspirin. 0 mg/kg dapat mencegah ulkus lambung pada tikus yang diinduksi aspirin.Kata kunci: daun pepaya (Carica papaya L.), ulkus lambung, aspirin
Weight Management among School-Aged Children and Adolescents: A Quantitative Assessment in a Ghanaian Municipality
Authors: Gyamfi Daniel , Obirikorang Christian , Acheampong Emmanuel , Asamoah Evans Adu , Sampong Bernard Berko , Batu Emmanuella Nsenbah , Anto Enoch Odame 
Published: August 2019

Abstract
Background: Childhood and adolescent overweight, obesity and underweight have become an issue of grave concern to both the developed and developing countries in context of global burden of non-communicable diseases. Unhealthy weight status is a significant public health issue for developing countries, of which Ghana is not excluded. This study evaluated the prevalence of overweight, obesity and underweight and its related factors among school-aged children and adolescents. Methods: A total of 1004 participants were randomly selected from six schools. A structured questionnaire on demography and socioeconomic status of students’ parents/guardians were completed by the selected students. Anthropometric parameters (weight, height, waist, and hip) were measured, and body mass index (BMI) and waist-to-height ratio (WHtR) were calculated. BMI-for-age z-scores were used to categorize anthropometric data of the children as underweight, normal, overweight or obese. A cut-off value of >0.50 was used to define obesity by WHtR. Results: Overweight prevalence of 13.8% and 12.6 was observed among basic school and high school student respectively based on BMI classification. Obesity prevalence of 8.8% was found in basic school students and 8.9% among high school student. Underweight was observed in 114 (11.3%) basic school students and 86 (8.6%) high school students. There was a difference in sex prevalence in unhealthy weight-behaviours; with more girls being overweight (19.4% vs 7.6%, p < 0.001) and obese (10.2% vs. 7.3%, p=0.177) compared to boys. High WHtR found in 10.5% of basic students and 5.0% of high school students, with a statistical difference. Overweight/obesity was significantly associated with taking snacks before bed among basic school students [aOR=10.45(5.95-18)] and high school students [aOR=10.23(5.95-18.37)] respectively. Watching TV [aOR=0.39(0.22-0.70)], sleeping during leisure periods [aOR=0.43(0.23-0.81)] and bicycling as a means of transport [aOR=0.37(0.19-0.72)] to school was protective of obesity among basic school students. Conclusion: High prevalence of unhealthy weight-related behaviours was observed among school-aged children in the Bekwai Municipality with significant. Snacking before bed was a major factor promoting obesity among school-aged children whiles leisure behaviours such as TV watching, and sleeping was protective of obesity. Therefore, it is recommended to Promote and support healthy eating habits among school-aged children which are likely beneficial in reducing the risk of childhood unhealthy weight-related behaviours.
Genetic and clinical characterization of BRCA-associated Hereditary Breast and Ovarian Cancer in Navarra (Spain)
Authors: de Sabando Ainara Ruiz , Lafuente Edurne Urrutia , García-Amigot Fermín , Sánchez Ángel Alonso , Garofalo Lourdes Morales , Moreno Sira , Ardanaz Eva , Ramos-Arroyo Maria A 
Published: August 2019

Abstract
Background Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer. The purpose of this study is to analyse the demographic and molecular characteristics of BRCA germline mutations in Navarra, Spain, and to investigate the clinical profile of hereditary and sporadic breast cancer (BC) and ovarian cancer (OC) in the Community. Methods The study includes 1246 individuals assessed for BRCA1/2 genetic testing in Navarra, during 2000-2016, and a cohort of BC (n=4384) and OC (n=561) from the population-based Navarra Cancer Registry. Distribution and molecular characteristics of BRCA1/2 mutations, as well as, comparative analysis of the clinical course, pathologic features and overall survival of patients in different risk groups were investigated. Results BRCA mutation detection rate was 16%, with higher proportion (63%) of BRCA2 families. Nineteen per cent of mutations were recurrent, one of which, BRCA2 c.6024dupG, showed high association to OC. BRCA carriers had double risk (95% CI=1.04-4.33) of developing multiple malignancies than low risk families and were diagnosed at a much earlier age (16.6 and 11.7 years difference for BC and OC, respectively) when compared to the general population. For BC, BRCA carriers showed a more advanced histological stage, higher risk of bilateral neoplasms (OR=4.3; 95% CI=1.3-11.4, for BRCA2 carriers) and worse overall survival rate at 5-, 10- and 15- years, than women with sporadic tumors. For OC, over 70% of patients of all risk groups showed advanced stages at diagnosis, with the highest 91% among BRCA1 carriers (91%). Furthermore, they also had higher probability of developing bilateral tumors (OR=7.8, 95%CI=1.7-55.7) than the general population. Five-year overall survival rate was worse among women with sporadic OC than in BRCA carriers, but it levelled out over the 15-year period. Conclusions This study describes the molecular features of BRCA1/2 mutations in Navarra and defines the clinical course and outcomes of BRCA associated tumors compared with those of sporadic origin. Long term assessment of mortality and survival will be required to evaluate the impact of BRCA genetic testing program on the health of target population in our community.
TOPK Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Activating Src/GSK3β/STAT3 Signal Pathway though γ-catenin
Authors: Jiang Yanan , Zhang Jing , Zhao Jimin , Li Zhenzhen , Chen Hanyong , Qiao Yan , Chen Xinhuan , liu kangdong , Dong Ziming 
Published: August 2019

Abstract
Background
Esophageal squamous cell carcinoma (ESCC) is a deadly disease with the poor prognosis in the world. The distal metastasis is the most death reason of ESCC. It is needed to have a comprehensive understanding of the molecular mechanism of metastasis to increase the free survive rate. T-LAK cell-originated protein kinase (TOPK) which is a MAPKK-like kinase takes an vital role in many physical and pathophysiological progress. However, the function of TOPK in ESCC metastasis was unclear.
Methods
Tissue array was used to evaluate the relationship between TOPK and ESCC patient with lymph node metastasis. Wound healing assay, transwell assay and lung metastasis mice model were assessed for the role of TOPK in the migration of ESCC cells in vitro and in vivo respectively. Protein kinase array, MS and molecular modeling were carried out to find the relational pathways and target protein of TOPK. Even, immune-fluorescence and western blot were performed to evaluate the mechanism of TOPK.
Results
We found that the high level of TOPK was correlated with the aggressive phenotype in ESCC tissues. Knocking down TOPK inhibited the invasion and migration of ESCC cells. We also verified that TOPK inhibitor HI-TOPK-032 inhibited the lung metastasis in ESCC cell exnograft model. Even more, molecular investigation indicated that TOPK promoted the invasion of ESCC cells by activing Src/GSK3β/STAT3, ERK pathway by binding with γ-catenin.
Conclusion
These findings reveal that TOPK was sincerely related with ESCC cell metastasis and TOPK promoted the invasion of ESCC cells by activing Src/GSK3β/STAT3, ERK pathway. This means that TOPK may be a potential molecular target for ESCC in clinic.