bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patulous nasolacrimal duct with air reflux: a complication of submucosal diathermy of the inferior turbinate
Authors: Puttasiddaiah P M , Whittet C R , Shuttleworth G N 
Published: August 2018

AbstractBackgroundSubmucosal diathermy to the inferior turbinate is a widely practised procedure to improve the nasal airway when nasal obstruction is due to hypertrophy of the inferior turbinate. This paper reports a case of an unusual nasolacrimal complication following submucosal diathermy to the inferior turbinate, and reviews the relevant literature.Case reportA 33-year-old male patient developed a patulous nasolacrimal duct opening following submucosal diathermy of the inferior turbinate. This resulted in spontaneous reflux of air and nasal mucus on to the ocular surface.ConclusionThis newly recognised complication of submucosal diathermy to the inferior turbinate indicates the need to be aware of the potential risk to the nasolacrimal system with this technique.
Asian Plantation Histories at the Frontiers of Nation and Globalization
Authors: MANJAPRA KRIS 
Published: August 2018

AbstractThis is a review article of four new books on plantation histories of Asia which offer a sophisticated analysis of the configurations of liberal imperialism, colonial capitalism, and the construction of post-colonial nationalism in the nineteenth and twentieth centuries. The works discussed here are Rana Behal'sA hundred years of servitude(2014); Jayeeta Sharma'sEmpire's garden(2011); Ulbe Bosma'sThe sugar plantation in India and Indonesia(2013); and Kumari Jayawardena and Rachel Kurian'sClass, patriarchy and ethnicity on Sri Lankan plantations(2015).
Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae)
Authors: Catalano Stefano , Bâ Khalilou , Diouf Nicolas D. , Léger Elsa , Verocai Guilherme G. , Webster Joanne P. 
Published: August 2018

AbstractHydatigera (Cestoda: Taeniidae) is a recently resurrected genus including species seldom investigated in sub-Saharan Africa. We surveyed wild small mammal populations in the areas of Richard Toll and Lake Guiers, Senegal, with the objective to evaluate their potential role as intermediate hosts of larval taeniid stages (i.e. metacestodes). Based on genetic sequences of a segment of the mitochondrial DNA gene cytochrome c oxidase subunit 1 (COI), we identified Hydatigera parva metacestodes in 19 out of 172 (11.0%) Hubert's multimammate mice (Mastomys huberti) and one out of six (16.7%) gerbils (Taterillus sp.) and Hydatigera taeniaeformis sensu stricto metacestodes in one out of 215 (0.5%) Nile rats (Arvicanthis niloticus). This study reports epidemiological and molecular information on H. parva and H. taeniaeformis in West African rodents, further supporting the phylogeographic hypothesis on the African origin of H. parva. Our findings may indicate significant trophic interactions contributing to the local transmission of Hydatigera spp. and other parasites with similar life-cycle mechanisms. We therefore propose that further field investigations of rodent population dynamics and rodent-borne infectious organisms are necessary to improve our understanding of host–parasite associations driving the transmission risks of rodent parasites in West Africa.
The structure of idioms in Nigerian English
Authors: Umar Aliyu Muhammad 
Published: August 2018

The term ‘structure in linguistics’ is mostly used to refer to a sequence of units that are in a certain linguistic relationship to one another. Thus no matter how minimal a sequence is, if it can be analysed in terms of a relationship within it, then that is a structural unit. For example, one of the structures of a noun phrase may be ‘article + adjective + noun’ as inthe vicious circle(Richards & Schmidts, 2002). Structures entail relationships which may be syntagmatic or paradigmatic. According to Finnegan (2014) when we say language structure we are essentially talking about syntax, semantics and phonology of a language. When it comes to idioms the same principles apply. The structures of idioms are essentially their syntactic behaviour. This behaviour cannot be predicted solely on the basis of their form or figurative meaning alone, but it must be due to some relation between the form and meaning (Gibbs & Nayak, 1989). An idiom is an institutionalised and conventionalized sequence of at least two words or free morphemes that is semantically restricted so that it functions as a single lexical unit, whose meaning cannot or can only to a certain extent be deduced from the meanings of its constituents. (Skandera, 2003: 60). To Nurnberg, Sag and Wasow (1994), idioms are characterised as having conventional meaning, figuration, inflexibility of form, and proverbiality. Idioms have been called ‘multiword units’ (Grant & Bauer, 2004), metaphors (Gibbs, 1993; Toris, 2011), phrasemes (Howarth, 1998), fixed expressions (Moon, 1997; Carter, 1998) and formulaic expressions (Wray, 2002). Structurally, idioms do not form a unique class of linguistic items such that all idioms belong to it, but that they share many of the same properties normally associated with more literal expressions.
Mechanical circulatory support using modified TandemHeart ventricular assist device in neonates with CHD
Authors: Chowdhury Shamsur , Chadha Tanya , Fafard Mark , Shillingford Michael 
Published: August 2018

AbstractTandemHeart, an adult ventricular assist device, is also being used in children for mechanical circulatory support. In this case series, we describe our experience using TandemHeart ventricular assist device with a modified circuit to provide mechanical circulatory support in three neonates for multiple indications. TandemHeart ventricular assist device with a modified circuit can be used successfully to provide extracorporeal support to neonates with complex CHD.
The much-awaited Venezia applicator: virtues of combined intracavitary and interstitial brachytherapy in locally advanced cervical cancer
Authors: Gangopadhyay Aparna , Saha Subrata 
Published: August 2018

SummaryLocally advanced cervix cancer is a major health problem in resource-limited areas of the world. Brachytherapy following pelvic chemoradiation is challenging, as large irregular clinical target volumes need adequate dose delivery while respecting limits of normal tissue tolerance. Achieving this is practically impossible using intracavitary brachytherapy alone. Consequently, combined intracavitary and interstitial brachytherapy provides higher chances of local control.
The PUFFinCA scale: development of an instrument for evaluating the primary care functions of family physicians in childhood asthma
Authors: Usturali Mut Ayşe Nur , Öcek Zeliha Aslı , Çiçeklioğlu Meltem , Taner Şafak , Demir Esen 
Published: August 2018

AbstractAimTo develop the Primary care fUnctions oF Family physicians in Childhood Asthma (PUFFinCA) scale for evaluating the cardinal process functions of primary care services (accessibility, comprehensiveness, continuity and coordination) provided by family physicians (FPs) in the management of childhood asthma.BackgroundIn the literature on the functions of primary care, there is no assessment tool focusing on children with asthma. Primary care assessment scales adapted to various languages are not suitable to adequately address the needs of special patient groups, such as children with asthma.MethodsIn this methodological study, the instrument development process was completed in four stages: establishing the pool of items, evaluating the content validity, applying the scale and statistical analysis. The scale was applied to 320 children who had asthma and received care in the clinic of the Department of Pediatrics, Division of Allergy and Pulmonology at Ege University School of Medicine, Turkey. The Cronbach’sαand Spearman–Brown coefficient were calculated to determine the reliability of the scale. Principal component analysis was used to determine the construct validity of the scale.FindingsThe PUFFinCA scale was found to have four-factor structure and 25 items. Cronbach’sαcoefficient was 0.93. It has been determined that the reliability was excellent and the item-total correlation coefficients were >0.30 each. The factors were titled FP’s ‘functions of accessibility, first contact and continuity’, ‘functions of coordination and comprehensiveness of health services related to asthma management’, ‘provision of preventive care related to asthma’ and ‘provision of services for paid vaccinations’.
Liquid-crystal-based amplitude tuner and tunable SIW filter fabricated in LTCC technology
Authors: Prasetiadi Ananto E. , Jost Matthias , Schulz Baerbel , Quibeldey Matthias , Rabe Torsten , Follmann Ruediger , Jakoby Rolf 
Published: August 2018

AbstractTunable microwave devices will play an important role in future wireless systems, in which high-frequency bands, e.g. millimeter waves, will become promising, due to its huge spectrum availability. At such frequency bands, liquid crystals (LCs) exhibit low microwave loss, which is excellent compared with the other tuning elements. In this paper, LC-based microwave components are fabricated by using low temperature co-fired ceramic technology, allowing the integration of the LC into microwave structures. The first component, the amplitude tuner, controls the signal's amplitude by using the interference concept, which exhibits a tunable attenuation range from 11 dB to 30 dB at 30 GHz. The second component is a 3-pole tunable bandpass filter, which is realized by using a substrate integrated waveguide topology, enabling a device with comparatively high-quality factors (Q-factors). The measurement results show Q-factors in the range of 68 to 100 for a frequency tuning of 29.4–30.1 GHz, i.e. a tuning range of 700 MHz, accompanied by an insertion loss 2 dB to 4 dB.
Reliability analysis of BiCMOS SiGe:C technology under aggressive conditions for emerging RF and mm-wave applications: proposal of reliability-aware circuit design methodology
Authors: Lahbib Insaf , Wane Sidina , Doukkali Aziz , Lesénéchal Dominique , Dinh Thanh Vinh , Leyssenne Laurent , Germanicus Rosine Coq , Bezerra Françoise , Rolland Guy , Andrei Cristian , Imbert Guy , Martin Patrick , Descamps Philippe , Boguszewski Guillaume , Bajon Damienne 
Published: August 2018

AbstractIn this contribution, the impact of extreme environmental conditions in terms of energy-level radiation of protons on silicon–germanium (SiGe)-integrated circuits is experimentally studied. Canonical representative structures including linear (passive interconnects/antennas) and non-linear (low-noise amplifiers) are used as carriers for assessing the impact of aggressive stress conditions on their performances. Perspectives for holistic modeling and characterization approaches accounting for various interaction mechanisms (substrate resistivity variations, couplings/interferences, drift in DC and radio frequency (RF) characteristics) for active samples are down to allow for optimal solutions in pushing SiGe technologies toward applications with harsh and radiation-intense environments (e.g. space, nuclear, military). Specific design prototypes are built for assessing mission-critical profiles for emerging RF and mm-wave applications.
Combined Influence of the Arctic Oscillation and the Scandinavia Pattern on Spring Surface Air Temperature Variations Over Eurasia
Authors: Chen Shangfeng , Wu Renguang , Song Linye , Chen Wen 
Published: August 2018

AbstractThe present study investigated the joint impacts of the spring Arctic Oscillation (AO) and the Scandinavia (SCAND) teleconnection pattern on spring surface air temperature (SAT) variations over the midhigh latitude Eurasia. It is found that the connection of the spring AO (SCAND) to the first two empirical orthogonal function (EOF) modes of the spring Eurasian SAT variations depends strongly on the phase of the spring SCAND (AO) index. The EOF1 and EOF2 modes display same sign variation and tripole pattern, respectively. In the in‐phase AO‐SCAND years, the mid‐high latitude Eurasia is covered by same sign SAT anomalies, and the spring AO and SCAND indices both have a strong (weak) connection with the EOF1 (EOF2) mode. In the out‐of‐phase AO‐SCAND years, the SAT anomalies over the mid‐high latitude Eurasia are featured by a tripole pattern, and the connection of the spring AO and SCAND indices with the EOF1 (EOF2) is insignificant (significant). Differences in the distribution of SAT anomalies between the in‐phase and out‐of‐phase AO‐SCAND years are attributed to the constructive and destructive superposition of atmospheric circulation anomalies related to the spring AO and SCAND indices. The observed joint impacts of the spring AO and SCAND on spring Eurasian SAT variations are captured by a historical simulation of the flexible global ocean‐atmosphere‐land system model, spectral version 2. Analysis indicates that the prediction skill of the spring Eurasian SAT variations related to the first two EOF modes is enhanced when taking both the spring AO and SCAND signals into account.
Biological determinants of health disparities in multiple myeloma
Authors: Smith Cheryl Jacobs , Ambs Stefan , Landgren Ola 
Published: August 2018

AbstractMultiple myeloma is a rare plasma cell cancer, and incidence rates among patients of African descent are about twice those among patients of European descent. Rates of multiple myeloma vary among different populations, but the reasons for the racial disparities in multiple myeloma are largely unknown. Epidemiology has identified risk factors for multiple myeloma including race, advanced age, gender, family history, and exposure to different genetic toxins including radiation. Race and ancestry play a large role in predicting the risk for multiple myeloma, yet there exists a paucity of literature that explores the molecular contribution of race and ancestry to disease. In this review, we describe the relevant literature that describes the observed racial differences according to distinct tumor immunobiological and ancestral differences in populations.
BAG3 regulates stability of IL-8 mRNA via interplay between HuR and miR-4312 in PDACs
Authors: Li Chao , Jiang Jing-Yi , Wang Jia-Mei , Sun Jia , An Ming-Xin , Li Si , Yan Jing , Wang Hua-Qin 
Published: August 2018

AbstractBcl-2 associated athanogene 3 (BAG3) is highly expressed in pancreatic ductal adenocarcinoma (PDAC), and its high expression appears to be a poor prognostic factor for patients with PDAC. In this study, we show that BAG3 knockdown significantly decreases migration and invasion of PDACs via reduction of interleukine-8 (IL-8) production. BAG3 knockdown regulates IL-8 expression at the posttranscriptional levels via interplay between recruitment of RNA-binding protein HuR and miR-4312. HuR binds to the cis-elements located in the 3′-untranslational region (UTR) of the IL-8 transcript to stabilize it, whereas miR-4312-containing miRNA-induced silencing complex (miRISC) is recruited to the adjacent seed element to destabilize it. The binding of HuR prevents the recruitment of Argonaute (Ago2), overriding miR-4312-mediated translation inhibition of IL-8. BAG3 knockdown decreases cytoplasmic distribution of HuR via increasing its phosphorylation at Ser202, therefore compromising its recruitment while promoting recruitment of miR-4312 containing miRISC to IL-8 transcript. Furthermore, our data indicate that only phosphorylated Ago2 at Ser387 interacts with IL-8 transcript. BAG3 knockdown increases phosphorylation of Ago2 at Ser387, thereby further promoting loading of miR-4312 containing miRISC to IL-8 transcript. Taken together, we propose that BAG3 promotes invasion by stabilizing IL-8 transcript via HuR recruitment, and subsequently suppressing the loading of miR-4312 containing miRISC in PDACs. Our results reveal a novel pathway linking BAG3 expression to enhanced PDAC metastasis, thus making BAG3 a potential target for intervention in pancreatic cancer.
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation
Authors: Zheng Gang , Zhan Yu , Li Xiaobin , Pan Zongyou , Zheng Fanghong , Zhang Zengjie , Zhou Yifei , Wu Yaosen , Wang Xiangyang , Gao Weiyang , Xu Huazi , Tian Naifeng , Zhang Xiaolei 
Published: August 2018

AbstractThe blockage of autophagic flux in chondrocytes has been considered as a major reason for the excessive cellular apoptosis and senescence in osteoarthritis (OA) development; however, the molecular mechanism and therapeutic strategy for interrupted autophagic flux is still not clear. Most recently, the transcription factor EB (TFEB) is identified as a master regulator for autophagic flux via initiating the expression of multiple autophagy-related genes and lysosomal biogenesis. This research was performed to confirm whether TFEB expression and activity are impacted in OA development and to confirm the effect of genetic up-regulation of TFEB on autophagic flux and cellular protection in the in vitro and in vivo models of OA. We demonstrated that the expression and nuclear localization of TFEB is decreased in human and mouse OA cartilage as well as in tert-Butyl hydroperoxide (TBHP)-treated chondrocytes. Applying lentivirus to transfect chondrocytes, we found that TFEB overexpression rescues the TBHP-induced the autophagic flux damage, lysosome dysfunction and protects chondrocyte against TBHP induced apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition. Our destabilized medial meniscus (DMM) mouse OA model shows that TFEB overexpression ameliorates the surgery-induced cartilage degradation, restrains the apoptosis and senescence of chondrocyte, and enhances the autophagic flux. In summary, our study indicates that the activity of TFEB in chondrocyte is involved in OA development, also TFEB overexpression may be a promising strategy for OA treatment.
Enhanced autophagy contributes to excitotoxic lesions in a rat model of preterm brain injury
Authors: Descloux Céline , Ginet Vanessa , Rummel Coralie , Truttmann Anita C. , Puyal Julien 
Published: August 2018

AbstractCystic periventricular leukomalacia is commonly diagnosed in premature infants, resulting from severe hypoxic-ischemic white matter injury, and also involving some grey matter damage. Very few is known concerning the cell death pathways involved in these types of premature cerebral lesions. Excitotoxicity is a predominant mechanism of hypoxic-ischemic injury in the developing brain. Concomitantly, it has been recently shown that autophagy could be enhanced in excitotoxic conditions switching this physiological intracellular degradation system to a deleterious process. We here investigated the role of autophagy in a validated rodent model of preterm excitotoxic brain damage mimicking in some aspects cystic periventricular leukomalacia. An excitotoxic lesion affecting periventricular white and grey matter was induced by injecting ibotenate, a glutamate analogue, in the subcortical white matter (subcingulum area) of five-day old rat pups. Ibotenate enhanced autophagy in rat brain dying neurons at 24 h as shown by increased presence of autophagosomes (increased LC3-II and LC3-positive dots) and enhanced autophagic degradation (SQSTM1 reduction and increased number and size of lysosomes (LAMP1- and CATHEPSIN B-positive vesicles)). Co-injection of the pharmacological autophagy inhibitor 3-methyladenine prevented not only autophagy induction but also CASPASE-3 activation and calpain-dependent cleavage of SPECTRIN 24 h after the insult, thus providing a strong reduction of the long term brain injury (16 days after ibotenate injection) including lateral ventricle dilatation, decreases in cerebral tissue volume and in subcortical white matter thickness. The autophagy-dependent neuroprotective effect of 3-methyladenine was confirmed in primary cortical neuronal cultures using not only pharmacological but also genetic autophagy inhibition of the ibotenate-induced autophagy. Strategies inhibiting autophagy could then represent a promising neuroprotective approach in the context of severe preterm brain injuries.
ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis
Authors: Zhang Yu , Zhou Hang , Tao Yongjun , Liu Xingyu , Yuan Zhu , Nie Chunlai 
Published: August 2018

AbstractThe expression of IκB kinase β (IKKβ) promotes the growth of breast cancer cells. Meanwhile, IKKβ mediates the phosphorylation and subsequent degradation of arrest-defective protein 1 (ARD1). However, the relationship between IKKβ and ARD1 in the occurrence of breast cancer has not been reported. In this study, we found that IKKβ not only acts directly on mammalian target of rapamycin (mTOR) activity but also indirectly acts on mTOR activity through posttranscriptional modification of ARD1, thereby effectively promoting the growth of breast cancer cells. ARD1 prevents mTOR activity and breast cancer cell growth by stabilizing tuberous sclerosis complex 2 (TSC2) to induce autophagy. Moreover, acetylation of heat shock protein 70 (Hsp70) also contributes to ARD1-mediated autophagy. Therefore, upstream IKKβ can further promote the occurrence of breast cancer by mediating the function of ARD1.
MALAT1–miR663a negative feedback loop in colon cancer cell functions through direct miRNA–lncRNA binding
Authors: Tian Wei , Du Yantao , Ma Yuwan , Gu Liankun , Zhou Jing , Deng Dajun 
Published: August 2018

AbstractThe lncRNA MALAT1 has multiple biological functions, including influencing RNA processing, miRNA sponging, and cancer development. It is acknowledged that miR663a and its targets are inflammation-related genes frequently deregulated in many cancers. The associations between MALAT1 and miR663a and their target genes remain unknown. In this study, it was found that in colon cancer (CC) cells, MALAT1 and miR663a were reciprocally repressed in cDNA array screening and qRT-PCR analysis. However, MALAT1 was significantly upregulated in CC tissues, and miR663a was significantly downregulated relative to the corresponding surgical margin (SM) tissues. An inverse relationship between MALAT1 and miR663a expression was detected among CC tissue samples (n = 172, r = −0.333, p < 0.0001). The RNA-pulldown results showed MALAT1 lncRNA–miR663a binding. The results of luciferase-reporter analysis further revealed that the MALAT1 7038–7059 nt fragment was the miR663a seed sequence. Both miR663a knockdown and MALAT1 activation alone significantly upregulated the expression levels of miR663a targets, including TGFB1, PIK3CD, P53, P21, and JUND, in the CC cell lines HCT116 and SW480. A positive relationship was also observed between the expression levels of MALAT1 and these miR663a targets in the above 172 CC samples and 160 CC samples in publicly available databases. In addition, reciprocal abolishment of the effects of miR663a overexpression and MALAT1 activation on the proliferation, migration, and invasion of cancer cells was also observed, while miR663a upregulation and MALAT1 activation alone inhibited and promoted the behaviors of these CC cell lines, respectively. All these suggested that, as a competing endogenous lncRNA, MALAT1 maybe a dominant protector for the degradation of miR663a targets. miR663a and MALAT1 may consist of a negative feedback loop to determine their roles in CC development.