bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A65: Effect of voluntary running on metastasis in a mouse model of breast cancer
Authors: Rundqvist Helene , Mijwel Sara , Ahlstedt Emil , Lindholm Carolin , Strell Carina , Roswall Pernilla , Pietras Kristian , Johnson Randall , Ostman Arne 
Published: May 2019

Abstract
Introduction: Breast cancer is one of the most common neoplastic diseases. Emerging evidence states that regular physical exercise provides a risk reduction for breast cancer by approximately 25 %. In addition, recent studies suggest that physical activity may also have an effect on recurrence and mortality. Mouse models are suitable tools to study anti-neoplastic mechanisms.
Aim: To evaluate the effect of voluntary running on tumor initiation, growth and metastasis in mouse models of breast cancer.
Methods: From 4 weeks of age, MMTV-PyMT mice were housed with access either to wirelessly recording running wheels or locked control wheels. Running distances and tumor volumes were recorded. At 12 weeks, mice were sacrificed and mammary glands were histologically staged and pulmonary metastases were quantified. In a follow up study, pre-trained mice were injected intravenously with tumor cells derived from the PyMT model and after an additional 10 weeks of voluntary running, pulmonary metastases were quantified.
Results: PyMT mice ran significantly more than wildtype mice (6.4 vs 3.4 km/day). No significant effects of voluntary running on tumor- initiation, volume or stage were found. However, a trend for reduced metastasis was observed. Significant reductions in pulmonary metastasis frequency were found in runners after intravenous injections of tumor cells. Metastases of running mice displayed a reduced proliferation score.
Discussion: In this aggressive breast cancer model, an average of 6 km/day of voluntary running produces little effect on tumor formation and growth. However, the findings suggest that physical activity has impact on the metastatic process.
Citation Format: Helene Rundqvist, Sara Mijwel, Emil Ahlstedt, Carolin Lindholm, Carina Strell, Pernilla Roswall, Kristian Pietras, Randall Johnson, Arne Ostman. Effect of voluntary running on metastasis in a mouse model of breast cancer. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr A65.
Abstract B01: Body fatness throughout life and the incidence of endometrial cancer
Authors: Dougan Marcelle M. , Vivo Immaculata De , Tworoger Shelley S. , Hankinson Susan E. , Michels Karin B. 
Published: May 2019

Abstract
Background: Although adult obesity is known to increase endometrial cancer (EC) risk, evidence for the role of childhood obesity is limited. We prospectively examined the association between body fatness throughout the life-course and EC risk.
Design: Participants, 47,289 members (527 cases) of the Nurses' Health Study (NHS), and 105,386 members (130 cases) of the Nurses' Health Study II (NHS II) recalled their body fatness at ages 5, 10, and 20 using a nine-level pictogram. Childhood and adolescent body fatness were the average between ages 5 and 10, and ages 10 and 20, respectively. We obtained weight from biennial questionnaires and calculated relative risks (RR) of EC using Cox proportional hazards models. All statistical tests were two-sided.
Results: In the NHS, body fatness was associated with EC at age 10, adolescence, age 20, and adulthood, but not at age 5 or childhood (RR for EC comparing most overweight to least overweight in adolescence was 1.51, 95% CI 1.08-2.11, Ptrend 0.02). For NHS II, the associations were stronger (RR, comparing most overweight to least overweight in adolescence was 2.91, 95% CI 1.83-5.98, Ptrend &lt;0.001). However, after adjusting for current body mass index (BMI), none of the associations persisted (NHS: RR was 0.93, 95% CI 0.65-1.32 Ptrend 0.40; NHS II: RR was 1.14, 95% CI 0.59-2.20, Ptrend 0.73). The association between adult BMI and EC was similar across both cohorts.
Conclusion: These findings indicate that body fatness in early life is not independently associated with endometrial cancer risk.
Citation Format: Marcelle M. Dougan, Immaculata De Vivo, Shelley S. Tworoger, Susan E. Hankinson, Karin B. Michels. Body fatness throughout life and the incidence of endometrial cancer. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B01.
Abstract B06: Dissemination and implementation research in health: What it is and opportunities for funding
Authors: Neta Gila , Chambers David , Vinson Cynthia , Glasgow Russ 
Published: May 2019

Abstract
Epidemiologists and public health researchers are increasingly interested in the translational value of their research. However, only a small fraction (estimated at 14 percent) of scientific discoveries are ever translated into public health practice, and the process from discovery to translation is exceedingly slow – approximately 17 years. There is a clear need for greater speed, relevance and application of scientific discoveries into programs and policies. In the past decade, the National Cancer Institute and the National Institutes of Health (NIH) expanded their mission to include practice-based research to best understand how scientific discoveries and evidence-based interventions can best be translated not only into clinical or community applications but to have a broader impact on population health through changes in policy and practice. Through trans-NIH funding announcements, 15 institutes and centers at the NIH currently are soliciting proposals for research in the field of dissemination and implementation research in health. For the purposes of these announcements, dissemination is defined as the targeted distribution of information and intervention materials to a specific public health or clinical practice audience. The intent is to spread (or scale-up) and sustain knowledge and the associated evidence-based interventions. Implementation is the use of strategies to adopt and integrate evidence-based health interventions and change practice patterns within specific settings. In this presentation we will describe in more detail the emerging field of dissemination and implementation research in health, identify priority research areas that are highlighted in the program announcements, and provide advice on how to prepare an application. We also will provide additional information on training opportunities in dissemination and implementation science, and we will describe resources that are available for cancer researchers. Finally, we will discuss emerging areas including issues such as sustainability, reach and representativeness, cost-effectiveness, and de-implementation (particularly in regard to overtreatment and overdiagnosis in cancer.)
Citation Format: Gila Neta, David Chambers, Cynthia Vinson, Russ Glasgow. Dissemination and implementation research in health: What it is and opportunities for funding. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B06.
Abstract B13: Modeling childhood versus adolescent HPV vaccination in Mali, West Africa
Authors: Schluterman Nicholas H. , Tracy J Kathleen 
Published: May 2019

Abstract
Objectives: Several regions in the developing world, including West Africa, bear a disproportionately high burden of cervical cancer. Incorporating the human papillomavirus (HPV) vaccine into existing childhood vaccination programs may be a practical way to combat cervical cancer in these settings.
Procedures: A compartmental mathematical model compared the occurrence of HPV and cervical cancer outcomes in childhood (age: 1 year) and adolescent (age: 10-14 years) vaccination scenarios over 75 years in Mali, West Africa. The model contained three prominent novel features: adjustable age of vaccination, waning vaccine-induced immunity at a rate of 1% annually, and moderate cross-protection against non-vaccine high-risk HPV (HR-HPV) types.
Results: Compared to a scenario with no vaccination, childhood vaccination resulted in a 53.8% (at 50% vaccine coverage) reduction in combined prevalence of all modeled HPV types in Year 75, whereas adolescent vaccination resulted in a prevalence reduction of 52.7%. After 50 years, childhood and adolescent vaccination produced 15.4% and 22.8% reductions, respectively, in the total number of life-years lost to cervical cancer. From Year 51 to Year 75, childhood vaccination reduced the total number of life-years lost by 42.9%, compared to 45.7% for adolescent vaccination.
Conclusion: Adolescent vaccination will produce a more immediate impact on cervical cancer outcomes than will childhood vaccination, but the effects of the two approaches become similar once the vaccinated cohorts span all living generations. Childhood HPV vaccination could be a practical long-term option for resource-limited countries with existing childhood vaccination programs.
Citation Format: Nicholas H. Schluterman, J Kathleen Tracy. Modeling childhood versus adolescent HPV vaccination in Mali, West Africa. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B13.
Abstract B14: Trends in academic publications on oncology in East Asia: A 10-year survey of the English literature in China, Japan and Korea
Authors: Yu Zhiqi , Xing Junjie , Du Yan , Wang Hantao , Cao Guangwen , Fu Chuangang 
Published: May 2019

Abstract
Background: The incidence and mortality of malignant diseases keep increasing in East Asia, especially in China. The research status on oncology in East Asia is largely unknown. The quality and quantity of academic publications can reflect the research activity. Here, we analyzed contributions of Japan, Korea and China in this field. Methods: We searched PubMed and Web of Science databases for articles published in oncology journals between 2003 and 2012. The total number of articles, citations, impact factors, and the number of articles published in high Impact Factor and the most popular oncology journals were compared among the contributing authors from Japan, Korea and China. Results: During the past decade from 2003 to 2012, 31,338 related articles were published in 96 oncology journals selected. The number of articles from China increased significantly, while there was a notable decline in Japan, and a modest increase in Korea, with an annual incremental rate of 24.97%, -1.69% and 12.66%, respectively. However, the accumulative IF of articles from Japan was higher than that from China (6298.8 vs. 3970.5, p = 0.059) and Korea (6298.8 vs. 2017.2, p = 0.005). Japanese oncologists contributed more publications to international oncology societies with respect to clinical trials, randomized controlled trials and case reports, and published more articles in top oncology journals as compared with China (1212 vs. 524, p = 0.015) and Korea (1212 vs. 344, p = 0.008). Conclusions: Although oncology research in China has been greatly improved over the past 10 years, there is still a significant gap between China and Japan with respect to high-level research on oncology. It is therefore an unshakable responsibility for Chinese oncologists to conduct high level original research and clinical trials on oncology, given China's big population and high cancer incidences.
Note:This abstract was not presented at the conference.
Citation Format: Zhiqi Yu, Junjie Xing, Yan Du, Hantao Wang, Guangwen Cao, Chuangang Fu. Trends in academic publications on oncology in East Asia: A 10-year survey of the English literature in China, Japan and Korea. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B14.
Abstract B18: Breast health promotion among African immigrant women: Intervention recommendations
Authors: Odeneye Ebun O. 
Published: May 2019

Abstract
Breast cancer is now the most common cancer both in developed and developing countries. It is also the leading cause of cancer-related deaths among females in economically developing countries. Additionally, breast cancer among African women is quite aggressive and progressive in nature, and often occurs earlier in life. This, coupled with the fact that African women make up one of the fastest growing immigrant population in the United States and immigrants have been shown to have lower rates of mammogram uptake, warrants scientific inquiry about how to effectively promote awareness and support breast cancer early detection and prevention practices in this population. Using Intervention Mapping (IM), a systematic approach to intervention development, recommendations for a program to promote breast health among African immigrant women in the United States will be presented. Final program recommendations are grounded in current scientific literature on breast health promotion strategies, qualitative formative research through semi-structured interviews with women, and theoretical considerations. The resultant program is a comprehensive, multilevel, evidence-based, culturally-appropriate and theory-driven educational curriculum for African immigrant women. Performance objectives (e.g., “obtain an annual mammogram”) will be specified, and behavioral determinants (e.g. knowledge, attitude and self-efficacy) will be discussed as part of a detailed matrix of change objectives for African immigrant women and community leaders. Innovative approaches, theoretical methods and practical strategies, in addition to program materials and activities, will also be described.
Citation Format: Ebun O. Odeneye. Breast health promotion among African immigrant women: Intervention recommendations. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B18.
Abstract B20: Self-reported memory problems in adult-onset cancer survivors in the United States: Effects of cardiac complications, short sleep duration, and general health
Authors: Jean-Pierre Pascal , Grandner Michael , Henry Elizabeth 
Published: May 2019

Abstract
Background: Memory impairments are debilitating adverse effects of malignant tumors and their various treatments. Factors such as cardiac complications and sleep loss/impairment can exacerbate memory problems for cancer patients and survivors. We examined the relationships among history of cardiac complications, short sleep duration, and self-reported memory problems (SRMP) in adult-onset cancer survivors.
Methods: We included data from middle-aged (41 to 64 years) participants who completed the 2007-2008 National Health and Nutrition Examination Survey (NHANES), a nationally representative, stratified, multistage probability sample of the civilian, non-institutionalized population of the United States. We excluded participants with a history of brain cancer or stroke since these conditions are expected to cause cognitive problems because of direct insults to the brain. Using binary a logistic regression, we determined the prevalence of SRMP in cancer survivors relative to cardiac complications and short sleep duration (&lt; 5 hours/night) by weighting our results proportionally. We controlled for demographic predictors of memory problems: age, sex, race, education and general health.
Results: The sample included 2,289 adults (49% female). There were 46% Whites, 20% Blacks, 29% Hispanics, and 4% Asian/other. A total of 9% of the sample were cancer survivors. Cardiac complications (Odds ratio (OR), 6.97, p &lt; 0.029; 95%CI, 1.21 to 40.05) and short sleep duration (OR, 25.30, p &lt; 0.002; 95%CI, 3.35 to 191.28) statistically significantly predicted SRMP that interfere with activities of daily functioning. Short sleep duration partially mediated the relationship between cardiac complications and SRMP to the order of 9.18% (p &lt; 0.0001). Among participants without a cancer history, neither cardiac complications nor short sleep were associated with SRMP (p &gt; 0.05).
Conclusion: The likelihood of SRMP is higher in cancer survivors with a history of cardiac complications or short sleep duration. Future studies are needed to systematically delineate the cardiac-sleep-memory relationships, which could inform the development of reliable assessment and intervention to mitigate memory impairments and sleep problems for cancer survivors.
Citation Format: Pascal Jean-Pierre, Michael Grandner, Elizabeth Henry. Self-reported memory problems in adult-onset cancer survivors in the United States: Effects of cardiac complications, short sleep duration, and general health. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B20.
Abstract B35: Aberrant expression of ABCC3 in rectal cancer predicts poor prognosis and pathological response to neoadjuvant chemoradiotherapy via activating the caspase-3 dependent apoptotic pathway
Authors: Yu Zhiqi , Zhang Chang , Gao Xianhua , Xing Junjie , Wang Hao , Yu Enda , Zhang Wei , Zhang Xiaoqing , Cao Guangwen , Fu Chuangang 
Published: May 2019

Abstract
Objective: To clarify the role of ATP binding cassette subfamily C member 3 (ABCC3) on prognosis and pathological response to neoadjuvant chemoradiotherapy in rectal cancer, and further explore the potential molecular mechanism. Design: Retrospective analysis of clinicopathologic factors and detection of ABCC3 expression in pretreatment biopsy specimens from 144 cases of stage II–III rectal cancer who received neoadjuvant chemoradiotherapy and radical surgery. Pathological response according to tumor regression grade and long-term survival curve were further determined. ABCC3 expression was down-regulated using short interfering RNA in colorectal carcinoma cells HT-29 and SW-480. Cell proliferation and apoptosis in response to 5-fluorouracil or irradiation were examined using colony formation assay, single-hit multi-target model, flow cytometry and Hoechst 33342 staining, respectively. Tumor growth following fractional irradiation was measured in xenograft mouse model. Change of intracellular reactive oxygen species contents and activation of cleaved caspase-3 expression were further explored. Results: Aberrant expression of ABCC3 was an independent factor significantly predicting poor pathological response to neoadjuvant chemoradiotherapy (P=0.002) and prognosis (3-year Overall Survival: P=0.011; 3-year Disease-free Survival: P=0.003). Down-regulation of ABCC3 expression significantly increased 5-fluorouracil or irradiation induced cell apoptosis in vitro, and tumor growth was significantly suppressed following irradiations in vivo. Furthermore, inhibition of ABCC3 expression obviously activated caspase-3 dependent apoptotic pathway and decreased intracellular reactive oxygen species exporting from cells after being exposed to irradiations. Conclusion: ABCC3 is an attractive target for improving sensitivity to neoadjuvant chemoradiotherapy and of potential value for a clinical breakthrough in the comprehensive treatment of rectal cancer patients.
Note:This abstract was not presented at the conference.
Citation Format: Zhiqi Yu, Chang Zhang, Xianhua Gao, Junjie Xing, Hao Wang, Enda Yu, Wei Zhang, Xiaoqing Zhang, Guangwen Cao, Chuangang Fu. Aberrant expression of ABCC3 in rectal cancer predicts poor prognosis and pathological response to neoadjuvant chemoradiotherapy via activating the caspase-3 dependent apoptotic pathway. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B35.
Abstract B49: Prediagnostic body-mass index, smoking, and prostate cancer survival
Authors: Yuan Changzheng , Chavarro Jorge , Lindström Sara , Kraft Peter , Ma Jing 
Published: May 2019

Abstract
Background: Few prospective studies have sufficient power to investigate the relationship between obesity and lethal prostate cancer (PC) in detail or within population subgroups, such as by smoking status. This study aimed to investigate the associations of pre-diagnostic body mass index (BMI) with risk of progression from time of PC diagnosis to fatal outcome, to assess effect modification by smoking status and to evaluate the joint effect of BMI and smoking on PC survival.
Methods: We conducted a survival analysis of 10,206 PC patients from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). BMI and smoking status were estimated before PC diagnosis. Deaths among PC patients were categorized into deaths from PC and other causes. We conducted the analysis in 3 parts according to exposures: BMI (18-22.9 kg/m2, 23-24.9 kg/m2. 25-27.9 kg/m2, 28-29.9 kg/m2, 30-34.9 kg/m2, 35 kg/m2+), smoking (Never, former, current) and their joint effect, respectively. Each analysis was performed on prostate cancer specific mortality and other mortality separately. Competing-risks regression model was used to take into account of other causes of death. For the above analyses, two models were used. Model 1 controlled for age at diagnosis, drinking status, diabetes status, cohort, duration between baseline and PC diagnosis; Model 2 further adjusted for PC stage and Gleason score at diagnosis in addition to model 1.
Results: There were 1028 deaths from PC and 1919 other deaths among all PC patients during an average follow up of eight years. Higher BMI was associated with higher risk of death from PC and other causes; compared to BMI (23-24.9 kg/m2) group, men with BMI 35+ kg/m2 had HR=1.83, 1.16-2.91 for PC death and HR=1.49, 1.04-2.14 for other deaths. The positive trend was apparent only among never and former smokers but not current smokers. Similar effect was found among men whose BMI measured &gt;5 years but for men whose BMI was measured &lt;=5 years before PC diagnosis, only those in the highest category (BMI 35+ kg/m2) was associated with higher risk of dying from PC. Former smokers as well as current smokers have significant higher risk of progressing to death after PC diagnosis regardless BMI with significant interaction between BMI and smoking.
Conclusions: Higher BMI and smoking history (former and current smokers) are possible risk factors for dying from PC among all PC cases in the BPC3 cohort. The effect of BMI on PC survival is modified by smoking status.
Citation Format: Changzheng Yuan, Jorge Chavarro, Sara Lindström, Peter Kraft, Jing Ma. Prediagnostic body-mass index, smoking, and prostate cancer survival. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B49.