bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia
Authors: Hu Yae , Li Hui , Yan Ruhong , Wang Can , Wang Yun , Zhang Ce , Liu Meng , Zhou Tiantian , Zhu Weipei , Zhang Hong , Dong Ningzheng , Wu Qingyu 
Published: November 2018

AbstractPre-eclampsia (PE) is a chronic inflammatory disease in pregnancy, which is associated with enhanced blood coagulation and high thrombotic risk. To date, the mechanisms underlying such an association are not fully understood. Previous studies reported high levels of plasma deoxyribonucleic acid (DNA) in PE women, but the cellular source of the circulation DNA remains unknown. In this study, we tested the hypothesis that activated neutrophils undergoing cell death, also called NETosis, may be responsible for the elevated plasma DNA levels in PE women. We analysed plasma samples from non-pregnant, normal pregnant and PE women and found high levels of double-stranded DNA, myeloperoxidase (an abundant neutrophil granular enzyme) and histones (the major nucleosome proteins) in PE-derived samples, indicating increased NETosis in the maternal circulation. The high plasma DNA levels positively correlated with enhanced blood coagulation in PE women. When isolated neutrophils from normal individuals were incubated with PE-derived plasma, an elevated NETosis-stimulating activity was detected. Further experiments showed that endothelial micro-particles, but not soluble proteins, in the plasma were primarily responsible for the NETosis-stimulating activity in PE women. These results indicate that circulating micro-particles from damaged maternal endothelium are a potent stimulator for neutrophil activation and NETosis in PE women. Given the pro-coagulant and pro-thrombotic nature of granular and nuclear contents from neutrophils, enhanced systemic NETosis may represent an important mechanism underlying the hyper-coagulability and increased thrombotic risk in PE.
Adverse Effects of Treatment with Valproic Acid during the Neonatal Period
Authors: Benevent J. , Montastruc J. L. , Touati G. , Hachon LeCamus C. , Baudou E. 
Published: November 2018

Introduction Valproic acid (VPA) is rarely used in neonatal period. In children under 2 years old, serious adverse effects are appear to be more frequent.
Aim The aim of our study is to report the adverse effects observed in a population of full-term newborns treated with VPA.
Method Full-term newborns, hospitalized at the Toulouse CHU, who presented with neonatal seizures and who received long-term treatment with VPA between 2004 and 2014 were included.
Results For 5 of the 123 newborns treated with VPA, treatment had to be discontinued due to adverse effects. Three patients presented with disturbances in consciousness within 48 hours of treatment initiation, one case with a moderate overdose and two with hyperammoniemia (157 and 327 μmol/L) without any drug overdose or underlying liver or metabolic disease (VPA-induced hyperammonemic encephalopathy). Two patients presented with secondary hematological alterations. No patient presented with liver toxicity or exacerbation of an underlying metabolic disease.
Conclusion While the serious adverse effects of VPA noted were all reversible with the discontinuation of the treatment, the occurrence of encephalopathies with hyperammoniemia is a serious complication that is potentially lethal and calls for close clinical monitoring of newborns treated with valproate. We provide precautions for the implementation and follow-up of VPA in newborns.
Investigating Intestinal Permeability of Bortezomib Using a Validated HPLC-UV Method
Authors: Mahmoudian Mohammad , Zakeri-Milani Parvin , Valizadeh Hadi 
Published: November 2018

AbstractBortezomib (BTZ), as a proteasome inhibitor, has been used for treatment of patients with relapsed/refractory multiple myeloma and mantle cell lymphoma. BTZ is available for intravenous injection or subcutaneous administration. In this study, for evaluating the potential of BTZ oral delivery, intestinal permeability of BTZ was determined using in situ single-pass intestinal perfusion (SPIP) technique and the perfused solutions were analyzed using a validated HPLC-UV method. The chromatographic separation was performed using a C18 column via isocratic mode at a flow rate of 0.5 mL/min at 270 nm. The mobile phase was a mixture of methanol/deionized water (50:50% v/v) with 0.1% glacial acetic acid. The results indicated that calibration curves were linear (r2 ˃0.99) in a concentration range of 1.65–5 µg/mL for BTZ and 8.33–25 µg/mL for phenol red. A limit of quantitation of 1.03 and 6.67 µg/mL was obtained for BTZ and phenol red, respectively. The recovery values were in the range of 96.5–105.4% for BTZ, and 88–99.2% for phenol red. The relative standard deviations (RSD) were ≤4.9% for BTZ and ≤7% for phenol red. Stability studies indicated that the working standard solution is stable over a period of 48 h at room temperature. Finally, an effective permeability (Peff) value of (3.36±0.5)×10−5 cm/sec (mean±SEM) was achieved for BTZ. Moreover, it was predicted that BTZ belongs to the biopharmaceutical class ІІІ.
Look, a human being! Anthropomorphic solipsism in postsecular thought
Authors: Vahanian Noëlle 
Published: November 2018

AbstractAdding a woman’s voice to an edited volume, or a person of color on an academic panel, or an ecumenical, universalist message of welcome under a church flag—these may be well intentioned gestures of inclusion, but, even as an unintended result, minority discourses either stand on the margins, as the ‘other,’ or they morph and disappear into the dominant discourse. What is needed instead is a change of ‘being.’ Whatever we call the philosophy of religion, it owes its conception to the European Enlightenment, and the latter, its understanding of the modern subject to Christian imperialism and the colonial enterprise. How can it ever become an inclusive field? This paper reflects on the promise of inclusion of postsecular theological discourses within the Continental philosophy of religion. Can such discourses, coming on the heels of the death of God and the postmodern death of universals, overcome their patriarchal, colonial, and racist cultural archive? Such a possibility glimpses a future worth pursuing. To answer the question, this paper plays on the intersectionality of the human being as such—an imagined abstract condition of possibility of our existence—and human facticity, the embodied lived experience that is historically conditioned, culturally determined, gendered and racialized as we know it today—identities expressing or underwriting white privilege, the economic exploitation of the global south, or hegemonic Western institutions of knowledge and power. The paper analyzes key aspects of well-known postsecular theological discourses (Caputo, Vattimo, Taylor, Levinas) through the intersectional lens of feminist, race, postcolonial, and decolonial critiques (Schutte, Du Bois, Carter, Dussel, Mignolo). Error is human, but today’s sexism, racism, or economic oppression suggest it isn’t human errors we ought to correct so much as our erroneous understanding of what we call a human being. A materialist conception of being (Malabou) and a theology whose God is in and of language open the way to engage the complicity of the philosophy of religion with the dominant and hegemonic ideologies that underwrite, besides the field, today’s world order.
Potential shift from a carbon sink to a source in Amazonian peatlands under a changing climate
Authors: Wang Sirui , Zhuang Qianlai , Lähteenoja Outi , Draper Frederick C. , Cadillo-Quiroz Hinsby 
Published: November 2018

Significance
We use a process-based biogeochemistry model to quantify the carbon accumulation for peatland ecosystems in the Pastaza-Marañon foreland basin in the Peruvian Amazon from 12,000 y before present to AD 2100. We find that warming accelerates peat carbon loss, while increasing precipitation slightly enhances peat carbon accumulation at millennial time scales. With these impacts, our simulations suggest that the basin might lose up to 0.4 Pg⋅C by AD 2100, with the largest loss from palm swamp. If this loss rate is true for all Amazonia peatlands, we project that these carbon-dense peatlands may switch from a current carbon sink into a future source in this century.
Detecting and explaining why aquifers occasionally become degraded near hydraulically fractured shale gas wells
Authors: Woda Josh , Wen Tao , Oakley David , Yoxtheimer David , Engelder Terry , Castro M. Clara , Brantley Susan L. 
Published: November 2018

Significance
Development of shale gas has changed the economics of global energy. However, methane sometimes escapes from shale gas wells into aquifers and the atmosphere. Although many researchers investigate leakage of this greenhouse gas, detection can be difficult where natural sources of methane are present. Here, methane was studied in water near gas wells previously cited for well integrity issues. We identify chemical clues that can distinguish methane migration related to shale gas development from methane that was preexisting. We also document a geological setting—the upper part of a large geological fold at shallow depth—that may be prone to methane migration. Knowledge gained from this study may lessen the chances for fugitive methane emissions into aquifers in the future.
Interlinked regulatory loops of ABA catabolism and biosynthesis coordinate fruit growth and ripening in woodland strawberry
Authors: Liao Xiong , Li Mengsi , Liu Bin , Yan Miaoling , Yu Xiaomin , Zi Hailing , Liu Renyi , Yamamuro Chizuko 
Published: November 2018

SignificanceUsing strawberry fruit as a model system, we uncover the mechanistic interactions between auxin, gibberellic acid (GA), and abscisic acid (ABA) that regulate the entire process of fruit development. Interlinked regulatory loops control ABA levels during fruit development. During the early stages, auxin/GA turns on a feedback loop to activate the removal of ABA viaFveCYP707A4a-dependent catabolism needed for fruit growth. Down-regulation of auxin/GA results in the suppression of the feedback loop and the activation of the ABA biosynthesis-dependent feedforward loop, leading to a steep ABA accumulation for fruit ripening. The interlinked regulatory loops provide a conceptual framework that underlies the connection between the regulation of fruit growth and that of ripening as well as a molecular basis for manipulation of fruit sizes and ripening times.
Dynamic effects of enforcement on cooperation
Authors: Galbiati Roberto , Henry Emeric , Jacquemet Nicolas 
Published: November 2018

Significance
This paper shows experimentally how past fines on noncooperation can affect cooperative behavior even when they are no longer in force. Our experiment allows us to separate different forces: a direct effect of past fines on individual preferences and an indirect effect driven by a response to others’ cooperation. We show that this second mechanism is prominent and creates a snowball effect of cooperation.
Loss of protein synthesis quality control in host-restricted organisms
Authors: Melnikov Sergey V. , van den Elzen Antonia , Stevens David L. , Thoreen Carson C. , Söll Dieter 
Published: November 2018

Significance
This case study reveals that parasitic and symbiotic lifestyles affect the structure of essential molecular machineries of a living cell. We provide evidence that intracellular parasitism and endosymbiosis cause degeneration of the editing domains in aminoacyl-tRNA synthetases, a defect that is known to cause inaccurate translation of the genetic code. This finding suggests that most intracellular pathogens, including causative agents of human disease, have an unanticipated proteome diversity caused by inaccurate translation of the genetic code. Our finding may change current approaches to the study of proteomes of intracellular parasites, parasite–host interactions, and parasites’ sensitivity to drugs, which cause errors in transcription, translation, and protein folding.
Links Between Behavior Change Techniques and Mechanisms of Action: An Expert Consensus Study
Authors: Connell Lauren E , Carey Rachel N , de Bruin Marijn , Rothman Alexander J , Johnston Marie , Kelly Michael P , Michie Susan 
Published: November 2018

Abstract

Background
Understanding the mechanisms through which behavior change techniques (BCTs) can modify behavior is important for the development and evaluation of effective behavioral interventions. To advance the field, we require a shared knowledge of the mechanisms of action (MoAs) through which BCTs may operate when influencing behavior.

Purpose
To elicit expert consensus on links between BCTs and MoAs.

Methods
In a modified Nominal Group Technique study, 105 international behavior change experts rated, discussed, and rerated links between 61 frequently used BCTs and 26 MoAs. The criterion for consensus was that at least 80 per cent of experts reached agreement about a link. Heat maps were used to present the data relating to all possible links.

Results
Of 1,586 possible links (61 BCTs × 26 MoAs), 51 of 61 (83.6 per cent) BCTs had a definite link to one or more MoAs (mean [SD] = 1.44 [0.96], range = 1–4), and 20 of 26 (76.9 per cent) MoAs had a definite link to one or more BCTs (mean [SD] = 3.27 [2.91], range = 9). Ninety (5.7 per cent) were identified as “definite” links, 464 (29.2 per cent) as “definitely not” links, and 1,032 (65.1 per cent) as “possible” or “unsure” links. No “definite” links were identified for 10 BCTs (e.g., “Action Planning” and “Behavioural Substitution”) and for six MoAs (e.g., “Needs” and “Optimism”).

Conclusions
The matrix of links between BCTs and MoAs provides a basis for those developing and synthesizing behavioral interventions. These links also provide a framework for specifying empirical tests in future studies.
Multilingualism and Mobility as Collateral Results of Hegemonic Language Policy
Authors: Albury Nathan John 
Published: November 2018

AbstractThis article shows, with Malaysia as a case study, that an ethnonationalist language policy need not have disempowering consequences for minorities. Malaysia politicizes ethnic difference between Malaysians of Malay, Chinese, and Indian descent. Ethnic Malays enjoy economic concessions unavailable to others, law defines Malaysia as Islamic and speaking Bahasa, and Malay ethnonationalism constructs Chinese– and Indian–Malaysians as perpetual visitors. Nonetheless, Bahasa has only added to the multilingual repertoires of non-Malays, rather than replaced it. This article analyses survey data about the multilingual practices of Malaysian youth and their folk linguistic talk about what guides their multilingualism. By drawing on critical language policy, it appears that policy may be so ethnonationalist that it has caused disassociation, especially amongst Indian–Malaysians, and sustained multilingualism. The Chinese–Malaysian experience, however, is better explained by a posthumanist perspective whereby language choices appear guided by material and immaterial resources within the Chinese–Malaysian community, rather than by matters of power or politics. In any case, the relative greater multilingualism of Chinese– and Indian–Malaysians was perceived as empowering non-Malay mobility despite ethnonationalist policy.
The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities
Authors: Baldini Federico , Heinken Almut , Heirendt Laurent , Magnusdottir Stefania , Fleming Ronan M T , Thiele Ines 
Published: November 2018

Abstract

Motivation
The application of constraint-based modeling to functionally analyze metagenomic data has been limited so far, partially due to the absence of suitable toolboxes.

Results
To address this gap, we created a comprehensive toolbox to model (i) microbe–microbe and host–microbe metabolic interactions, and (ii) microbial communities using microbial genome-scale metabolic reconstructions and metagenomic data. The Microbiome Modeling Toolbox extends the functionality of the constraint-based reconstruction and analysis toolbox.

Availability and implementation
The Microbiome Modeling Toolbox and the tutorials at https://git.io/microbiomeModelingToolbox.
Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study
Authors: Teepen Jop C , Kok Judith L , Kremer Leontien C , Tissing Wim J E , van den Heuvel-Eibrink Marry M , Loonen Jacqueline J , Bresters Dorine , van der Pal Helena J , Versluys Birgitta , van Dulmen-den Broeder Eline , Nijsten Tamar , Hauptmann Michael , Hollema Nynke , Dolsma Wil V , van Leeuwen Flora E , Ronckers Cécile M ,   DCOG-LATER Study Group
Published: November 2018

Abstract

Background
Skin cancer is common after radiotherapy among childhood cancer survivors (CCSs). We studied risks and risk factors for subsequent skin cancers, with emphasis on radiation dose, exposed skin surface area, and chemotherapeutic agents.

Methods
The DCOG-LATER cohort study includes 5-year Dutch CCSs diagnosed 1963–2001. Subsequent skin cancers were identified from record linkages with the Netherlands Cancer Registry and Dutch Pathology Registry. Incidence rates were compared with general population rates. Multivariable Cox regression models were used, applying a novel method of case-control sampling enabling use of tumor location in cohort analyses. All statistical tests were two-sided.

Results
Among 5843 CCSs, 259 developed 1061 basal cell carcinomas (BCCs) (standardized incidence ratio [SIR] = 29.8, 95% confidence interval [CI] = 26.3 to 33.6; excess absolute risk per 10 000 person-years (EAR) = 24.6), 20 had melanoma (SIR = 2.3, 95% CI = 1.4 to 3.5; EAR = 1.1), and 10 had squamous cell carcinoma (SIR = 7.5, 95% CI = 3.6 to 13.8; EAR = 0.8). Cumulative incidence of BCC 40 years after childhood cancer was 19.1% (95% CI = 16.6 to 21.8%) after radiotherapy vs 0.6% expected based on general population rates. After a first BCC, 46.7% had more BCCs later. BCC risk was associated with any radiotherapy to the skin compartment of interest (hazard ratio [HR] = 14.32, 95% CI = 10.10 to 20.29) and with estimated percentage in-field skin surface area (26–75%: HR = 1.99, 95% CI = 1.24 to 3.20; 76–100%: HR = 2.16, 95% CI = 1.33 to 3.53, vs 1–25% exposed; Ptrend among exposed = .002), but not with prescribed radiation dose and likelihood of sun-exposed skin-area. Of all chemotherapy groups examined, only vinca alkaloids increased BCC risk (HR = 1.54, 95% CI = 1.04 to 2.27).

Conclusion
CCSs have a strongly, 30-fold increased BCC risk. BCC risk appears to increase with increasing skin surface area exposed. This knowledge underscores the need for awareness by survivors and their health care providers.
Low-intensity shockwave therapy in the treatment of diabetic nephropathy: a prospective Phase 1 study
Authors: Skov-Jeppesen Sune Moeller , Yderstraede Knud Bonnet , Bistrup Claus , Jensen Boyle L , Marcussen Niels , Hanna Milad , Lund Lars 
Published: November 2018

AbstractBackgroundLow-intensity shockwave therapy (LI-SWT) is suggested as a therapy for promoting tissue regeneration. In pigs, it was recently found that LI-SWT improved renal function after ischaemic injury. Our objectives were to study glomerular filtration rate (GFR) and albuminuria in diabetic nephropathy (DN) after treatment with LI-SWT. The present pilot study reports on the clinical safety of LI-SWT in DN.MethodsA total of 14 patients with diabetes mellitus and Stage 3 chronic kidney disease were recruited for this prospective, one-arm Phase 1 study. The patients were treated with six sessions of LI-SWT during a 3-week period. At each session, 3000 shockwaves were applied to each kidney with 0.265 mJ/mm2, extended focal size and 4 Hz. Follow-up visits were performed at 1, 3 and 6 months.ResultsIn general, the treatment was well tolerated. Transient macroscopic haematuria was observed in three patients immediately after LI-SWT. The majority of patients experienced lower back tenderness lasting up to 2 days after treatment. There was no need for analgesic treatment. LI-SWT showed no negative effect on GFR and albuminuria. At baseline, median (interquartile range) GFR was 33.5 mL/min/1.73 m2 (27.8–43.8) compared with 36.0 mL/min/1.73 m2 (27.5–52.0) at 6 months follow-up. In parallel, median albuminuria was 256 mg/24 h (79–619) at baseline and tended to decrease to 137 mg/24 h (41–404) 6 months after LI-SWT. There was no statistical difference between baseline and follow-up results.ConclusionsLI-SWT is a safe treatment for DN. Inclusion of more patients is needed to determine whether LI-SWT can improve renal functional outcomes.
Evaluation of a Systems-Based Tobacco Cessation Program Using Bedside Volunteers
Authors: Taylor Denise S , Medaglio Dominique , Jurkovitz Claudine T , Patterson Freda , Zhang Zugui , Gbadebo Adebayo , Bradley Elisabeth , Wessells Rose , Goldenberg Edward 
Published: November 2018

Abstract

Introduction
Hospitalization and post-discharge provide an opportune time for tobacco cessation. This study tested the feasibility, uptake, and cessation outcomes of a hospital-based tobacco cessation program, delivered by volunteers to the bedside with post-discharge referral to Quitline services. Patient characteristics associated with Quitline uptake and cessation were assessed.

Methods
Between February and November 2016, trained hospital volunteers approached inpatient tobacco users on six pilot units. Volunteers shared a cessation brochure and used the ASK-ADVISE-CONNECT model to connect ready to quit patients to the Delaware Quitline via fax-referral. Volunteers administered a follow-up survey to all admitted tobacco users via telephone or email at 3-months post-discharge.

Results
Of the 743 admitted tobacco users, 531 (72%) were visited by a volunteer, and 97% (531/547) of those approached, accepted the visit. Over one-third (201/531; 38%) were ready to quit and fax-referred to the Quitline, and 36% of those referred accepted Quitline services. At 3 months post-discharge, 37% (135/368) reported not using tobacco in the last 30 days; intent-to-treat cessation rate was 18% (135/743). In a multivariable regression model of Quitline fax-referral completion, receiving nicotine replacement therapy (NRT) during hospitalization was the strongest predictor (odds ratios [OR] = 1.97; 95% confidence interval [CI] = 1.34 to 2.90). In a model of 3-month cessation, receiving Quitline services (OR = 3.21, 95% CI = 1.35 to 7.68) and having coronary artery disease (OR = 2.28; 95% CI = 1.11 to 4.68) were associated with tobacco cessation, but a volunteer visit was not.

Conclusions
An “opt-out” tobacco cessation service using trained volunteers is feasible for connecting patients to Quitline services.

Implications
This study demonstrates the feasibility of a systems-based approach to link inpatients to evidence-based treatment for tobacco use. This model used trained bedside volunteers to connect inpatients to a state-funded Quitline after discharge that offers free cessation treatment of telephone coaching and cessation medications. Receiving NRT during hospitalization positively impacted Quitline referral, and engagement with Quitline resources was critical to tobacco abstinence post-discharge. Future work is needed to evaluate the cost-effectiveness and sustainability of this volunteer model.