bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Characteristics and Acceptability of Chin-chin Prepared from Rice and High Quality Cassava Composite Flour
Authors: Adeyeye Samuel A.O. , Idowu-Adebayo Folake , Bolaji Olushola T. , Abegunde Titilope A. , Adebayo-Oyetoro Abiodun O. , Tiamiyu Hussaina K. 
Published: October 2019

Objective:This study was carried to assess the quality characteristics and acceptability of chin-chin prepared from rice and high-quality cassava composite flour.Methods:Chin-chin samples were made from the blends of rice flour (RF) and high quality cassava composite flour (HQCF) at varying proportions (100:0; 90:10; 80:20; 70:30; 60:40; 50:50; 0:100). The proximate composition, calorific and total energy values, physical quality, crust colour and the sensory properties of various chin-chin samples were analyzed.Results:The results showed that there was an inverse relationship between moisture, protein, fat, crude fibre and the ash of the chin-chin samples as the quantity of the high-quality cassava flour (HQCF) added increased. There was also a decrease in the values of proximate components of the chin-chin from RF. The % moisture, protein, crude fibre and ash ranged from 6.6 to 3.9, 7.9 to 4.6, 0.8 to 0.4 and 1.3 to 0.8 while % fat ranged from 18.4 to 24.7, respectively. The starch, sugar and calorific values of chin-chin samples ranged from 73.6 to 81.3%, 6.8-8.9 mg/100g, 431 to 496 cal/100 g respectively as the quantity of the high-quality cassava flour (HQCF) increased. As the quantity of the high-quality cassava flour increased in the chin-chin samples, the weight and volume ranged from 2.3 to 4.7 g and 1.8 to 0.8 cm3 respectively. The crust colour L*, a* and b* ranged from 68.01 to 78.81, 14.86 to 10.16 and 33.94 to 21.51 respectively. As the proportions of HQCF increased in the chin-chin, lightness of samples increased. The results of sensory evaluation showed that chin-chin samples from rice flour, HQCF and their composite flour had high sensory ratings and were acceptable to the consumers but chin-chin samples from 100% rice flour had highest overall consumer acceptability and were more preferred by the consumers when compared with chin-chin samples from rice and the high-quality cassava composite flour.Conclusion:In conclusion, it was observed that acceptable chin-chin could be prepared from rice and the high-quality cassava composite flour. Acceptable chin-chin samples could be produced optimally from rice-high quality cassava composite flour in a ratio of 60 to 40. However, it was also observed that chin-chin samples from 100% rice flour had the highest overall consumer acceptability and were more preferred by the consumers when compared with chin-chin samples from rice and the high-quality cassava composite flour.
What are the Characteristics of Patients Experiencing Adverse Drug Reactions to Oral Anticogulants and How Can Such Reactions be Prevented?
Authors: Spada G. , Vighi G.V. , Pagani S. , Vighi G.D. , Venegoni M. , Ruocco M. 
Published: October 2019

Introduction:
Oral anticoagulants, including vitamin K inhibitors (VKAs) and direct anticoagulants
(DOACs) are important for preventing and treating thromboembolic diseases.
However, they are not recommended for use in all patients due to negative side effects and adverse
drug reactions (ADRs). Currently, there is a paucity of information about their use in real life.
Therefore, the aim of this pilot study is to report on the rate of serious ADRs in oral anticoagulant
users, determine patient characteristics associated with increased risk of ADRs, and identify
possible management strategies for reducing risk of ADRs within a hospital setting.

Methods:
Patients admitted to the Internal Medicine Department of the Vimercate Hospital were
recruited between November 1, 2015 and October 31, 2016. All patients reporting an ADR
associated with anticoagulant use were selected. Demographic, clinical, and observational data were
extracted from electronic hospital records, in particular, by the hospital discharge letters and other
clinical records. The main outcome of the study was to evaluate the incidence of anticoagulants
serious adverse drug reactions conditioning hospital admission, the percentage of preventable reactions,
and the determinants of those.

Results and Discussion:
Of the 2,064 admissions, 102 (4.9%) eligible patients were identified. Age
ranged from 60-95 years (mean = 81.9, standard deviation = 6,59) and 47.1% (n=48) were female.
Of the 102 cases, 68 used VKAs and 34 used DOACs. The most common admission diagnosis was
heart failure following anemia or hemorrhage (56 cases), followed by acute hemorrhage (with or
without anemia; 29 cases), and anemia not associated with evident hemorrhage (17cases). The majority
of VKA users (n=65, 95.6%) had a high risk of major bleeding. ADRs were found to be preventable
in 96% of VKA users and 68% of DOACs users.

Conclusion:
This study highlights the large percentage of ADRs from oral anticoagulants that can be
avoided with more careful patient management. Periodic check-up of cardiac and renal function, as
well as blood count, may be useful for reducing the risk of ADRs, especially in older DOACs users.
Further research is needed to get new data to improve the patients monitoring system.
Synthesis and Biological Activity of a Bis-steroid-methanocyclobutanaphthalene- dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation
Authors: Lauro Figueroa-Valverde , Francisco Diaz-Cedillo , Marcela Rosas-Nexticapa , Virginia Mateu-Armand , Alejandra Garcimarero-Espino E. , Maria Lopez-Ramos , Lenin Hau-Heredia , Yaritza Borges-Ballote , Jhair Cabrera-Tuz 
Published: October 2019

Background:
There is some experimental data on the effect exerted by some
steroid derivatives against ischemia/reperfusion injury; however, the molecular mechanism
is very confusing, perhaps this phenomenon could be due to the protocols used and/or differences
in the chemical structure of each one of the steroid derivatives.

Objective:
The aim of this study was to synthesize a new bis-steroid-methanocyclobutanaphthalene-
dione derivative using some tools chemical.

Methodology:
The biological activity exerted by the bis-steroid-methanocyclobutanaphthalene-
dione derivative against ischemia/reperfusion injury was evaluated in an isolated
heart model using noradrenaline, milrinone, dobutamine, levosimendan, and Bay-K-
8644 as controls. In addition, other alternative experiments were carried out to evaluate the
biological activity induced by the bis-steroid-methanocyclobuta-naphthalene-dione derivative
against left ventricular pressure in the absence or presence of nifedipine.

Results:
The results showed that 1) the bis-steroid-methanocyclobuta-naphthalene-dione
derivative significantly decreases the ischemia-reperfusion injury translated as a decrease
in the the infarct area in a similar manner to levosimendan drug; 2) both bis-steroidmethanocyclobuta-
naphthalene-dione and Bay-K-8644 increase the left ventricular pressure
and 3) the biological activity exerted by bis-steroid-methanocyclobuta-naphthalenedione
derivative against left ventricular pressure is inhibited by nifedipine.

Conclusion:
In conclusion, the bis-steroid-methanocyclobuta-naphthalene-dione derivative
decreases the area of infarction and increases left ventricle pressure via calcium channels
activation; this phenomenon could constitute a new therapy for ischemia/reperfusion injury.
Origin of the Late Paleozoic metamorphic rocks in East Johor, Peninsular Malaysia
Authors: Surjono Sugeng Sapto , Leman Shafeea 
Published: October 2019

Low grade metamorphic rocks including slate, phyllite, metasandstone with subordinate schist and quartzite are widely distributed in the East Johor, Peninsular Malaysia. Regionally, this rock unit is extended northward up to northern Terengganu area. The protolith of this rocks unit were deposited in shallow marine depositional environment that subsequently metamorphosed during Carboniferous time. The very thick argillaceous and arenaceous rocks more than 5000 metres were produced by fast rate accommodation spaces due to global sea level rise during Early to Late Carboniferous against with high fine-grained sediment supply. Tectonic setting, basin formation and sedimentation processes were controlled by rifting of Indochina-East Malaya continental block from Gondwanaland during Devonian to Late Carboniferous. This rifting formed basins within a passive margin tectonic setting along the western margin of Indochina-East Malaya continental block.Keywords: Metamorphic rocks, shallow marine, Carboniferous, passive margin
The Effect of Extraction Method on Total Phenolic Content and Antioxidant Activity of Salam Leaves (Syzygium polyanthum) using DPPH (1,1-Diphenyl-2-Picrylhidrazil)
Authors: Luliana Sri , Riza Hafrizal , Indriyani Eneng Neni 
Published: October 2019

Extraction is an important step in separating bioactive compounds from the plant. The selection of extraction technique is also important in the standardization of herbal products, for if not observed it can remove the desired soluble constituents. One of Indonesia’s endemic plants which have been proven to have an antioxidant activity is Salam leaves (Syzygium polyanthum). This study aims to determine the effect of extraction method on total phenolic content and antioxidant activity of S. polyanthum leaves by counteracting free radicals mechanism using DPPH. The S. polyanthum leaves were extracted by maceration, soxletation, and infusa methods, and tested for the total phenolic content and the antioxidant activity. The results showed that the total phenolic content of each method extration is different. The total of the phenolic content extraction by maceration, soxhlet, and infusa method respectively were 338.62±21.3; 227.72±21.6; and 144.48±8.2 mgGAE/g. The best antioxidant activity was maceration method with IC50 17.53±0.11 µg/mL followed by soxhlet and infusa which were 18.73±0.31 and 40.26±0.18 µg/mL. The research conclusion is that the extraction method has an effect on the total phenol and antioxidant activity of S. polyanthum leaves.
Associations of Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated GFR
Authors: Novick Tessa K. , Surapaneni Aditya , Shin Jung-Im , Alexander G. Caleb , Inker Lesley A. , Wright Eric A. , Chang Alex R. , Grams Morgan E. 
Published: October 2019

Background and objectivesMost opioids undergo kidney excretion. The goal of this study was to evaluate opioid-associated risks of death and hospitalization across the range of eGFR.Design, setting, participants, & measurementsThe study population included adult primary care patients in Geisinger Health (Danville, PA) between 2008 and 2017. People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR.ResultsThe propensity-matched cohort included 46,246 patients prescribed either opioids or NSAIDs between 2008 and 2017 (mean [SD] age, 54 [16] years; 56% female; 3% of black race). Prescriptions for 1–59 and ≥60 MMEs were associated with higher risk of death (HR, 1.70; 95% CI, 1.41 to 2.05 for 1–59 MMEs; HR, 2.25; 95% CI, 1.82 to 2.79 for ≥60 MMEs) and hospitalization (HR, 1.38; 95% CI, 1.30 to 1.46 for 1–59 MMEs; HR, 1.68; 95% CI, 1.56 to 1.81 for ≥60 MMEs) compared with NSAID prescriptions, when evaluated at eGFR 80 ml/min per 1.73 m2. The relative risk of death associated with ≥60 MMEs was higher at lower GFR (e.g., eGFR, 40 ml/min per 1.73 m2; HR, 3.94; 95% CI, 2.70 to 5.75;Pfor interaction, 0.01). When gabapentinoids were used as the comparison medication, only ≥60 MMEs were significantly associated with higher risk of death (HR, 2.72; 95% CI, 1.71 to 4.34), although both 1–59 and ≥60 MMEs were associated with risk of hospitalization (HR, 1.22; 95% CI, 1.04 to 1.43 for 1–59 MMEs; HR, 1.54; 95% CI, 1.28 to 1.86 for ≥60 MMEs).ConclusionsThe receipt of prescription opioids was associated with a higher risk of death and hospitalization compared with other pain medications, particularly with higher doses and at lower eGFR.
Positive deviance approaches to improving vaccination coverage rates within healthcare systems: a systematic review
Authors: Singh Sonal , Mazor Kathleen M , Fisher Kimberly A 
Published: October 2019

Aim:
Our objective was to systematically review the use of the positive deviance approach to identify strategies to improve vaccination coverage rates.
Materials & methods:
We searched English language articles in Medline, Embase, Cochrane Library, CINAHL and PsycINFO without any date restrictions on 4 October 2017. We compiled a list of all strategies and evaluated the quality of these studies using the QATSDD tool.
Results:
After a review of 241 citations, we included eight studies. These studies focused on a wide variety of vaccines and settings. Core strategies that support vaccine uptake include the importance of tailoring and targeting in both messaging and delivery of vaccines and tracking delivery of vaccines. Patient and provider education, reminders, feedback loops, community collaborations, immunization registries and use of a medical home were also identified as other strategies.
Conclusion:
Our findings highlight several useful core strategies, which can be used to promote vaccination coverage. PROSPERO: CRD42017078221.
Ferric carboxymaltose for patients with heart failure and iron deficiency in Italy: cost–effectiveness and budget impact
Authors: Rognoni Carla , Gerzeli Simone 
Published: October 2019

Aim:
To evaluate the cost–effectiveness of intravenous ferric carboxymaltose (FCM) versus placebo for the management of iron deficiency in patients with chronic heart failure in the Italian healthcare system and to estimate its impact on the national healthcare budget.
Materials & methods:
A Markov model was developed to project costs and health outcomes over 1 year, based on data from literature. Healthcare resources consumption was derived from an e-survey administered to clinicians. Costs were obtained from official tariffs.
Results:
Treatment with FCM represents a dominant strategy compared with placebo, leading to national budget annual savings of 20–97 million Euros, according to different increasing utilization rates.
Conclusion:
FCM is a cost-saving option for the treatment of chronic heart failure patients with iron deficiency in Italy.
Ninety-Five Years of the Journal of the Canadian Historical Association/ Revue de la Société Historique du Canada
Authors: Duquet Michel , Holler Jacqueline 
Published: October 2019

This article traces the ninety-five-year history of the Journal of the Canadian Historical Association and its contribution to research dissemination, the building of a scholarly community, and services to authors.L’article retrace l’historique de la Revue de la Société historique du Canada et sa contribution à la diffusion de la recherche, le développement de la communauté savante et les services aux auteurs depuis quatre-vingts quinze ans.
Faktor Determinan Perilaku Pencegahan Primer Kanker Serviks Pada Remaja Putri
Authors: Antarsih Novita Rina , Kusumastuti Ani 
Published: October 2019

Latar belakang: Penyakit kanker merupakan salah satu penyebab kematian utama di seluruh dunia. Penyakit kanker serviks dan payudara merupakan penyakit kanker dengan prevalensi tertinggi di Indonesia tahun 2013, yaitu kanker serviks sebesar 0,8‰ dan kanker payudara sebesar 0,5‰. Faktor risiko terkena kanker 90-95 % berhubungan dengan perilaku dan lingkungan, yang dapat ditekan melalui gerakan bersama, menyeluruh dan berkesinambungan untuk meningkatkan kepedulian masyarakat terhadap kanker serviks.
Tujuan: mengembangkan upaya pencegahan primer kanker serviks pada remaja putri dan memberikan masukan bagi sekolah
Metode: menggunakan studi kuantitatif dengan data primer yang diambil melalui survei yang dilakukan pada lokasi penelitian dengan menggunakan desain studi potong lintang (cross sectional). Data akan dianalisis secara multivariate Uji Regresi Logistik.
Hasil: sebagian besar responden berperilaku kurang dalam pencegahan primer kanker serviks (53,3%), variabel yang berhubungan yaitu pengetahuan, sikap, riwayat cairan vagina abnormal, merokok dan antioksidan, sedangkan faktor yang dominan terhadap perilaku pencegahan primer adalah konsumsi antioksidan dengan taraf signifikan 0,000 (CI 95% 2,5 - 19).
Kesimpulan: faktor yang berhubungan dengan perilaku pencegahan primer kanker serviks adalah pengetahuan, sikap, riwayat cairan vagina abnormal, merokok dan konsumsi antioksidan. Remaja putri harus memiliki gaya hidup yang sehat, terutama mengkonsumsi nutrisi kaya antioksidan sebagai pencegahan primer terhadap kanker serviks
The Impact of Structural Changes in the Indian Manufacturing Industries: 1980-2013
Authors: Fathipour Gholamreza , Gaikwad Pratibha S. 
Published: October 2019

With regard to the importance of the manufacturing, industrial sector for economic growth and its priority for motivating other sectors to development, the paper is aimed to study the structural changes condition in the Indian manufacturing industries. The changing in value-added of industrial activities due to industrial and economic policies is an important indicator for the recognition of manufacturing industries structure. We have analyzed the industrial structure and competitiveness of each industrial activity by using data value-added of manufacturing industries and common indexes such as the structural changes index in the period of 1980-2013. The results of structural index analysis showed that of textile products; leather; basic chemicals and chemical products in the periods of 1980-98 and also in the periods after 2000industries wearing apparel; dressing and dyeing of fur tanning and dressing of leather ; wood and products of wood; motor vehicles, trailers and semi-trailers; recycling; other transport equipment have been the industrial activities that their structural changes indexes has been positive and they have had the highest competitiveness in comparison to other industrial activities and the greatest opportunities to create value-added.
Plasma Copeptin and Risk of Lower-Extremity Amputation in Type 1 and Type 2 Diabetes
Authors: Potier Louis , Roussel Ronan , Marre Michel , Bjornstad Petter , Cherney David Z. , El Boustany Ray , Fumeron Frédéric , Venteclef Nicolas , Gautier Jean-François , Hadjadj Samy , Mohammedi Kamel , Velho Gilberto 
Published: October 2019

OBJECTIVE
Diabetes is the leading cause of nontraumatic lower-extremity amputations (LEAs). Identification of patients with foot ulcers at risk for amputation remains clinically challenging. Plasma copeptin, a surrogate marker of vasopressin, is associated with the risk of cardiovascular and renal complications in diabetes.

RESEARCH DESIGN AND METHODS
We assessed the association between baseline plasma copeptin and risk of LEA during follow-up in four cohorts of people with type 1 (GENESIS, n = 503, and GENEDIAB, n = 207) or type 2 diabetes (DIABHYCAR, n = 3,101, and SURDIAGENE, n = 1,452) with a median duration of follow-up between 5 and 10 years. Copeptin concentration was measured in baseline plasma samples by an immunoluminometric assay.

RESULTS
In the pooled cohorts with type 1 diabetes (n = 710), the cumulative incidence of LEA during follow-up by increasing tertiles (tertile 1 [TER1], TER2, and TER3) of baseline plasma copeptin was 3.9% (TER1), 3.3% (TER2), and 10.0% (TER3) (P = 0.002). Cox regression analyses confirmed the association of copeptin with LEA: hazard ratio (HR) for 1 SD increment of log[copeptin] was 1.89 (95% CI 1.28–2.82), P = 0.002. In the pooled cohorts of type 2 diabetes (n = 4,553), the cumulative incidence of LEA was 1.1% (TER1), 2.9% (TER2), and 3.6% (TER3) (P &lt; 0.0001). In Cox regression analyses, baseline plasma copeptin was significantly associated with LEA: HR for 1 SD increment of log[copeptin] was 1.42 (1.15–1.74), P = 0.001. Similar results were observed in the cohort with type 2 diabetes for lower-limb revascularization (HR 1.20 [95% CI 1.03–1.39], P = 0.02).

CONCLUSIONS
Baseline plasma copeptin is associated with cumulative incidence of LEA in cohorts of people with both type 1 and type 2 diabetes and may help to identify patients at risk for LEA.
Measuring the performance of project risk management: a preliminary model
Authors: Serpell Alfredo Federico , Ferrada Ximena , Rubio Larissa 
Published: October 2019

Abstract
The function of project risk management (PRM) is to understand the uncertainty that surrounds a project and to identify the potential threats than can affect it as well as to know how to handle these risks in an appropriate way. Then, the measurement of the performance of PRM becomes an important concern, an issue that has not yet been addressed in the research literature. It is necessary to know how successful the application of the PRM process is and how capable is the process within the organization. Regarding construction projects, it is essential to know whether the selected responses to mitigate or eliminate identified risks were suitable and well implemented after the execution of the project. This paper presents a critical analysis of the relevance of measuring the performance of PRM and the benefits of doing so. Additionally, it presents a preliminary and pioneering methodology to measure the performance of PRM through the evaluation of the adequacy of responses applied to mitigate risks as well as to evaluate the resulting impacts as indicators of the effectiveness of these actions at the end of the project. This knowledge will allow construction companies to incorporate good practices, generate lessons learned, and thereby to promote a continuous improvement of the whole PRM process.
TOPONYMICAL DERIVATIVES AS THE ACTUALIZER OF PRECEDENT SITUATION (THE CASE OF THE SPANISH MASS MEDIA TEXTS)
Authors: Murzin Iu. P. 
Published: October 2019

This work is devoted to the study of one of the means of actualization of the precedent situation in the Spanish language on the materials of journalism. It examines the verbs formed from the names with the productive causative suffix values-izar, and also their derivatives – a gerund, indicating the action, and nouns with the suffix-ción, expressing the action and result of action – value motivational framework.These means are derived from the names of countries and regions, where in certain periods of their history there have occurred certain events, which served as the basis for the emergence of new words denoting phenomena and processes, characteristic not only of these countries, but also in other regions of the world.In contrast to the dictionary definitions of the nuclear meaning of these derivatives, their meaning when used as actualizers of the precedent situation is derived from the background, encyclopedic knowledge of the recipient or explicated in the context.Similar processes taking place in different countries may determine the synonymous nature of the respective derivatives. For example, the verbspanamizarandgibraltarizarbear the differential features of the precedent situation «colonization» in the economic and cultural spheres; derivativesvietnamizar,somalización,balcanizar,libanizarin their key value actualize a situation of «hostilities»;balcanizarandpolonizarcarry the meaning of «fragmentation of the state» and «termination of the existence of the subject».The results of this study can be used in courses on intercultural communication and cultural linguistics.