bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency and Risk Factors of Red Blood Cell Alloimmunization in Thalassemia Major Patients in Markazi province
Authors: MD Aziz Eghbali , MD Roghaieh.Rahimi-Afzal , MD Sarvenaz Mehrabi , MD Seyed Amir Sanatkar , MD Morteza Mousavi-Hasanzadeh 
Published: January 2019

Background: Thalassemia is one of the most common genetic disorders throughout the world. Blood transfusion plays an important role in the treatment of thalassemia but it leads to numerous complications such as iron overload and alloimmunization. This study evaluated the frequency and risk factors associated with alloimmunization in thalassemia major patients living in Markazi province, Iran.
Materials and Methods: In this descriptive study, 48 thalassemia major patients who underwent blood transfusion at Amirkabir hospital were included. Patients' demographic data were recorded using a questionnaire. In order to perform alloimmunization screening and autoantibody assessment, patients were referred to Tehran Blood Transfusion Organization Laboratory.
Results: The current study was performed on 48 patients with thalassemia major,. The mean age of patients was 12.5 ± 8.3 years. Among patients 26 (54.16%) were male and 22 (45.83%) were female, 13 patients (27.08%) had alloantibodies. Among 48 patients, 19 (39.58%) had undergone splenectomy. The patients' age of the first blood transfusion ranged from 1 month to 14 months and the mean age of the first blood transfusion was 9.5 ± 7.08 months. The blood transfusion intervals in patients were from 21 days to 40 days and the blood volume received at each transfusion session was 10-15 cc/kg of the body weight. In the current study, the data analysis indicated no significant correlation between alloantibodies and RH phenotype (P=0.43), patients' gender (P=0.9), or blood groups (P=0.4); whereas, a significant correlation was found between alloantibodies and splenectomy (P=0.02) as an increase in the prevalence of alloantibodies was reported in splenectomised patients.
Conclusion: No significant difference was found between the patients with and without alloantibodies in terms of the prevalence of Rh phenotype, gender, and blood groups. However, there was a significant difference between the patients with and without alloantibodies in terms of splenectomy.
Key words: Allo-immunization, Risk factors, Thalassemia major
The potential and prospects of the quantitative phase imaging (QPI) diagnostic technology in obstetrics and gynecology
Authors: Lifenko R. A. , Popova O. S. , Topuzov A. G. , Zverzhhovsky V. D. 
Published: January 2019

Rationale:An important role of immunological factors in the endometriosis pathophysiology allows for their consideration as diagnostic and prognostic disease markers. A promising approach to the diagnosis of immunological abnormalities is based on the non-invasive cell diagnostic technology of quantitative phase imaging (QPI), with underlying principles of laser interferometry and holography.Aim:To assess the QPI potential to identify diagnostic criteria for cell immunity abnormalities in female patients with external endometriosis.Materials and methods:We performed a quantitative assessment of the cytotoxic potential of peripheral blood lymphocytes from 22 patients with endometrioid ovarian cysts (mean age, 27.1 ± 3.4 years), 20 patients with uterine leiomyoma (mean age, 29.3 ± 4.1 years) and 20 health non-pregnant women of child-bearing age (mean age, 28.7 ± 3.6 years). We used the non-invasive QPI technique with the module for phase interference microscopy of the Russian hardand software complex Bioni (Westtrade Ltd., Russia).Results:We studied phase interference pictures of native lymphocytes to identify morphological and densitometry characteristics for CD4+ и CD8+ cells. Two groups of cells were identified in the cytotoxic lymphocyte population, which differed in their values of the phase thickness (Hcyt) and the area of cytoplasm adjacent to the membrane and containing the perforin granules (Scyt). It was found, that in the healthy controls the proportion of perforin-positive cytotoxic CD8+ lymphocytes was 37.1 ± 5.15%, in the patients with endometriosis 29.8 ± 6.34%, and in those with uterine leiomyoma 42.6 ± 5.89%.Discussion:Assessment of the lymphocyte cytotoxic potential by quantitative determination of cells containing perforin granules may be an important diagnostic and prognostic criterion of the disease course.Conclusion:Studies of the intracellular structures of lymphocytes by non-invasive and non-reagent technology QPI allows not only for a detailed evaluation of pathophysiological mechanisms of immune competent cell transformation in the course of a pathological process, but also gives future directions for development of new approaches to functional assessment of the immune system based on the results obtained.
The Processing of Hazardous and Toxic Hospital Solid Waste in Dr. Soetomo Hospital Surabaya
Authors: Purwanti Alvionita Ajeng 
Published: January 2019

The increasing number of hospital, increases medical waste in Indonesia. Medical waste is categorized as hazardous and toxic waste as mentioned in Appendix I of Government Regulation number 101 in 2014. The hazardous and toxic waste management in hospital is necessary because if it is not managed properly can cause injury, environmental pollution, and nosocomial disease. Hazardous and toxic hospital waste management can minimize the effect of it. The purpose of this study was to identify the flow of hazardous and toxic waste management in RSUD Dr. Soetomo according to the regulations. The research type was descriptive observational using secondary data from the installation of environmental sanitation. Data was compared to the Minister of Environment and Forestry Regulation No. P.56 in 2015 about Technical Procedures and Technical Requirements for the Hazardous and Toxic Waste’ s Management from Health Service Facilities. The results showed that the management of hazardous and toxic waste in RSUD Dr. Soetomo was fulfill the requirements in the regulation of the Minister of Environment and Forestry No. P.56 of 2015 from the reduction and segregation, storage, transportation and treatment of hazardous and toxic waste.
Relationship between House Sanitation and Number of Bacterial in Bed Room with Pneumonia Case of Children Under Five Years Old in Kenjeran Sub District Surabaya
Authors: Rahmawati Fitria Nur 
Published: January 2019

The number of pneumonia cases in children under five years found in Surabaya city in 2016 was 3,925 cases (40.89%). The number of pneumonia cases in children under five years in Kenjeran sub district was highers with 232 cases. This study was purposed to analyze the relationship between house sanitation and airborne bacterial number with pneumonia cases in children under five years old in the Kenjeran sub district, Surabaya. This study was designed as a case control study using 12 cases and 12 controls as the samplers. This research was conducted in Kenjeran sub district and took place from May to November 2017. Statistical test was using by chi square and multivariate logistic regression. The results of the study was that the cases of p neumonia in children under five years old were birth weight (p=0,01), nutritional status (p=0,01), sanitation house (p=0,03) and airborne bacterial number (p=0,01). Multivariate logistic regression test results showed that significant variables were nutritional status and airborne bacterial number. Nutritional status have the significance 0.04 (p <α) with OR=15,00. Airborne bacterial number have the significance 0.04 (p <α) with OR=15,00. The conclusion of this study is nutritional status and airborne bacterial number are associated with pneumonia under five years old. It is highly suggested to improve the quality of home health and child care.
B3 Waste Management and Health Workers Complaint In. Inka (Persero) Madiun City
Authors: Ichtiakhiri Tentrami Hayuning , Sudarmaji Sudarmaji 
Published: January 2019

Abstract: Disposal of industrial products containing chemical compounds especially harmful and toxic material negative impact on the environment and human health. PT. INKA (Persero) is a company engaged in manufacturing and railway services generating B3 waste from the production process.. B3 waste is used oil/oil cooler scars, B3 cans (cans of paint, thinner, drums), used batteries, sand ex. blasting, dust ex. blasting, plasma crust, former rags, waste fiber glass. B3 waste containing various heavy metals such as Pb, Cu, Hg, and Fe. This can be avoided by doing the B3 waste management in industry. The purpose of this research is describing the implementation of B3 waste management and perceived health complaints of workers. This research is a descriptive cross-sectional design. The sample of respondents was taken by total sampling with a sample size of 10 workers B3 waste management. The research variables are B3 waste management (sorting, storage, collection, transportation, utilization, processing, stockpiling) and health complaints. The results showed that PT. INKA (Persero) has not qualified in terms of B3 waste management such as sorting and storage. Health complaints are often perceived by employees is a headache and skin irritation. In this research required the supervision of B3 waste management in PT. INKA (Persero) as well as increased awareness of workers to wear protective equipment to manage waste.Keywords: B3 Waste Management, Health Complaints
The Mudharabah Savings Demand among the Member of Islamic Financial Service Cooperatives in Bogor
Authors: Aisyah Muniaty , Umiyati U. 
Published: January 2019

<p><em>The Islamic Financial Service Cooperative or Baitul Maal wa Tamwil (BMT) is potential to become an effective economic driving force</em><em>for micro and small businesses in Indonesia </em><em>due to its ability to raise public funds. Nevertheless, BMT experiences many obstacles, one of which in marketing. It needs a better understanding of its member behavior that could predict the demand of its products and services. This research aimed to examine the members’ demand on Mudharabah savings of BMT in Bogor, by using the multiple linear regression analysis. The finding shows that the service quality does not influence the members’ decision to use Mudharabah savings because the services provided by BMT are below of members’ expectation, thus, they need to enhance their service quality. This research sheds the light on some strategies in order to improve service quality of BMT in Indonesia.</em></p>
Lung cancer morbidity and mortality
Authors: Merabishvili V. M. , Arseniev A. I. , Tarkov S. A. , Barchuk A. A. , Shcherbakov A. М. , Demin E. V. , Merabishvili E. N. 
Published: January 2019

Background. According to a report by the International Agency for Research on Cancer (IARC), lung cancer (LC) is among the leading causes of morbidity and mortality worldwide, with an estimated incidence of 14.1 million new cases of the disease and 8.2 million cancer deaths in 2012. Lung cancer is the most common cancer worldwide, accounting for 13 % of all new cancer cases and 19.4 % of deaths.The purpose of the study was to evaluate LC prevalence and to measure the quality of population-based cancer registries by the indices of the proportion of total incident cases.Material and methods. The study material was given from the monograph «Cancer on Five Continents», which included data from the database of the Cancer Registry of PA. Herzen Moscow Research Oncology Institute (St. Petersburg), surveys of morbidity and mortality in the North-West Federal District, estimations of proportion of the true incidence that was registered in population-based registries.Results. The analysis of lung cancer morbidity and mortality in Russia showed a significant improvement in analytical indices over the past 10 years, however, underestimation of primary cases, reduced the overall lung cancer incidence rate.Conclusions. The dynamics of age-specific lung cancer incidence was shown. The loss of primary lung cancer cases was estimated to be 15-20 % annually.
Combined method for differential diagnosis of pancreatic cystic neoplasm
Authors: Koshel A. P. , Drozdov E. S. , Dibina T. N. , Klokov S. S. , Mironova E. B. , Rakina Yu. Yu. 
Published: January 2019

Objective.The frequency of detection of cystic neoplasm of the pancreas (CNP) has recently increased. Some of these neoplasms are benign, while others are malignant. Differential diagnosis between benign and malignant CNP remains challenging.Aim:to develop a combined method for differential diagnosis of CNP and to evaluate the role of the neutrophil to leukocyte ratio (NLR) as a diagnostic criterion of malignant CNP.Material and Methods. A retrospective analysis of the treatment of 82 patients with CNP, who underwent surgery between 2008 and 2018, was carried out. Benign lesions were detected in 62 patients and malignant tumors were diagnosed in 20 patients. The NLR and the serum levels of CA 19-9 as well as the presence of intracystic lesions were assessed as predictors of malignant CNP.Results. The presence of intracystic lesions detected by contrast-enhanced computed tomography and the elevated levels of serum CA 19-9 (>39 U/mL) and NLI (>1.876) were proven to be independent predictors of malignant CNP with statistical significance. The combination of all three criteria indicated malignant cystic neoplasm. The sensitivity, specificity and overall accuracy of the combined method were 71.4 %, 95.6 % and 86.5%, respectively.Conclusions.The combined method for differential diagnosis of malignant CNP is easy to use and has high accuracy. There is a direct correlation between NLI and malignant CNP.
High density lipoproteins of blood plasma as a transport form of actinomycin D
Authors: Polyakov L. M. , Knyazev R. A. , Ryabchenko A. V. , Trifonova N. V. , Kotova M. V. 
Published: January 2019

Introduction.The development of new and highly effective antitumor therapy is one of the priorities of pharmacology. The paper presents one of the solutions to the problem related to the development of transport forms of antitumor drugs.The aimof the study was to study the ability of various fractions of plasma lipoproteins (VLDLP, LDL, HDL) to interact with actinomycin D and show the role of HDL as a transport form of actinomycin D in the body cells.Material and methods. The studies were conducted using unlabeled and tritium-labeled actinomycin D, preparative ultracentrifugation of the rat plasma lipoprotein fractions, chromatography, and in vivo experiments with intravenous administration of HDL complexes with labeled actinomycin D.Results.The important role of HDL in the formation of complexes with actinomycin D in comparison with LDL and LPA was shown. The basic physicochemical characteristics of the interaction of HDL and apolipoprotein A-I with actinomycin were obtained. The constants of the association were of the order of 105 M-1, and the number of binding sites for the drug was 26 for HDL and 12 for apolipoprotein A-I. In vivo studies on rats, the highest radioactivity after intravenous injection of HDL complexes with tritium-labelled actinomycin D was observed in the adrenal glands, then in the liver and kidneys. The uptake of tritium-labelled actinomycin D was twice lower in the lungs, adipose tissue, thymus and spleen. The low uptake of the label was observed in the myocardial tissue.Conclusion.The results obtained demonstrate the feasibility of using HDL as a transport form of actinomycin D in body cells.
Proper nutrition at early age as the key to future health
Authors: Panasenko L. M. , Kartseva T. V. , Nefedova Zh. V. , Zadorina-Khutornaya E. V. , Khokhlova E. V. 
Published: January 2019

Each period of childhood is characterized by its own peculiarities of growth and development, the degree of morphological and functional maturity of individual organs and systems, the specifics of physiological and metabolic processes. Rational feeding and nutrition play a significant role in a child’s health. The authors presented modern approaches to the complementary food for children, its timing, taking into account the child’s readiness to receive new food, the composition of the dish, feeding technique, the formation of proper eating habits and behavior. The literature actively discusses the problem of the formation of taste preferences at early age; thisisthe period for the first acquaintance with varioustastes. The article demonstratesthe advantages of using products of industrial production. It is particularly important to overcome the negative attitude to new products – it determinesthe attention of the specialists to the problem of the introduction of complementary foods.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Analysis of statistical indicators of congenital anomalies as causes of early neonatal death in the Russian Federation
Authors: Tumanova U. N. , Shuvalova M. P. , Schegolev A. I. 
Published: January 2019

The article contains the analysis of Rosstat data for 2012–2016 on early neonatal death due to congenital developmental anomalies. From 2012 to 2016 there was an annual progressive decrease in the number of early neonatal deaths (from 6969 to 4113) in the Russian Federation. The total number of newborns died in the first 168 hours of life due congenital anomalies decreased from 1126 (2012) to 759 (2016), while the values of early neonatal mortality decreased from 366.4 to 217.8. However, the proportion of such infants increased from 16.2% (2012) to 18.5% (2016) from the total number of deaths in the early neonatal period. The type of defects and the frequency of their registration as the initial cause of early neonatal death differ in the federal districts of the Russian Federation and there are certain gender differences.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Phycocyanin as a proxy for algal blooms in surface waters: case study of Ukerewe Island, Tanzania
Authors: Mchau Geofrey J. , Makule Edna , Machunda Revocatus , Gong Yun Yun , Kimanya Martin 
Published: January 2019

Abstract
Knowledge of the parameters that contribute to water body eutrophication is essential for proper monitoring and management of water quality for human consumption. This study assessed water quality parameters in relation to phycocyanin (PC) as a proxy indicator for harmful algal blooms (HABs). Samples were collected from 23 water sources – lakes, wells, springs and boreholes – in selected villages, for six months. Parameters measured included temperature, pH, redox potential, dissolved oxygen, electrical conductivity, total dissolved solids, nitrate nitrogen, nitrite nitrogen, phosphorus, reactive phosphate and total chlorophyll, which were related to (PC) occurrence. The PC concentration detected in Lake Victoria ranged from 5 to 58.4 μg/l above the WHO alert level and exceeded that in other water sources by almost 30 μg/l (P &lt; 0.001). Univariate relationship between water quality parameters and PC indicates association with temperature, redox potential, total chlorophyll, nitrate nitrogen, nitrite nitrogen, phosphate and reactive phosphorus (P &lt; 0.001). The multivariate model indicates that redox potential, nitrate nitrogen and phosphorus are significant statistically (P &lt; 0.05). A predictive model indicates that nitrate nitrogen and reactive phosphorus contribute significantly to PC occurrence whereby unit (1 mg/l) increases in these parameters increase PC by 9.55 and 4.38 μg/l (P &lt; 0.05) respectively. This study demonstrates that water quality parameters can be used to predict increases in PC and hence as a proxy for HABs. It remains important to be able to classify algal blooms, to understand which species are present and their potential cyanotoxin production.
Cyclodextrin modified filter paper for removal of cationic dyes/Cu ions from aqueous solutions
Authors: Li Yaoyue , Zhou Yanbo , Zhou Yi , Lei Juying , Pu Shengyan 
Published: January 2019

Abstract
A filter paper was functionalized with β-cyclodextrin and citric acid via esterification reaction for the removal of dyes and Cu ions from aqueous solutions. The adsorption capacity and removal performance of the modified filter paper (MFP) was investigated using static and dynamic adsorption experiments. The static adsorption data fit well the Langmuir and pseudo-second-order models, and the adsorption capacity of Methylene Blue (MB), Brilliant Green (BG), Rhodamine-B (RB) and Cu(II) over the MFP were 124.6 mg/g, 130.4 mg/g, 99.7 mg/g and 39.1 mg/g, respectively, which are much higher than the unmodified filter paper (below 2 mg/g). Even better, the decolorization performance and Cu(II) removal of MFP are remarkable in dynamic adsorption. The effluent can reach the National Standard for dyeing and finishing of textile industry of China after three cycles in a continuous filtration-adsorption system. This method provides a new pathway to achieve high efficiency removal of dyes and metal ions from wastewater.
Importance of Oral Health in Pregnancy: A Mini-symposium
Authors: Priyamvara Aditi , Dey Amit K. , Bagchi Antara , Kelkar Raveena , Sharma Rajaram 
Published: January 2019

Background:It is known that hormonal imbalances during pregnancy make women more susceptible to dental problems. High levels of progesterone and estrogen during pregnancy, lead to an increased inflammatory response to dental plaque thus causing predisposing to gum diseases such as gingivitis. If untreated, gingivitis leads to chronic periodontitis which may manifest systemically in form of cardiovascular, endocrine or even respiratory disorders. Also, hyperacidity in the oral cavity due to gastric reflux and vomiting leads to decreased pH thus damaging the tooth enamel making the oral cavity more prone to tooth decay and tooth loss. Studies also show that periodontal disease can also lead to adverse pregnancy outcomes such as pre-term and low birth weight babies.Objectives:We sought to understand the role of oral health in pregnancy.Methods:We identified major articles of interest in the field of oral health in pregnancy and drafted a mini-symposium based on relevant information.Conclusion:Regular dental visits and cognizant efforts to sustain a healthy oral environment can help women in the prevention and treatment of dental issues during pregnancy. The paper highlights the common oral manifestations during pregnancy and their local and systemic impact on the body during pregnancy. Furthermore, it also emphasizes the importance of good oral health practices to counteract the oral complications and the significance of oral health awareness in pregnant women.
Cefdinir Microsphere Modulated Microflora and Liver Immunological Response to Diet Induced Diabetes in Mice
Authors: Patel Sweta , Mandaliya Dipeeka , Prajapati Bhumika , Kumar Sunny , Seshadri Sriram 
Published: January 2019

Objective:
Gut microbiota is currently targeted for various diseases especially metabolic disorders
such as diabetes. Our strategy is to alter gut microflora via specific antibiotic to reduce load of inflammation
in the liver that increases as a result of high carbohydrate diet. Th1, Th17 and Treg are important
immune cell types which decide the type of inflammatory response. Liver is tolerogenic in nature
with low Th17/Treg ratio. In diabetics, this ratio decreases even more, and can cause liver trauma.

Method:
The present study tries to find relationship between gut flora and immune cells such as
Th1/Th17/Treg and their role in liver metabolism using diet induced diabetic mice model.

Result:
Upon alteration of flora using Cefdinir in different forms, one could help lower the level of
Treg cells thus increasing the ratio. Gut flora is strongly associated with the immunity in the liver.
Targeted alteration of gut flora helps us to restore insulin sensitivity.

Conclusion:
Colon targeted Cefdinir gives more promising results, opens colonic bacteria as target for
improving gut, liver inflammation and insulin sensitivity.