bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Media Poster Gambar Dua Dimensi dalam Meningkatkan Kemampuan Bercerita Anak Usia Dini
Authors: Ariyani Ariyani 
Published: December 2024

Pendidikan bertujuan membina dan mengembangkan potensi anak usia dini agar dapat tumbuh dan berkembang secara optimal sesuai dengan tipe kecerdasannya. termasuk perkembangan keterampilan bahasa dan kemampuan bercerita. Aktivitas pembelajaran di sekolah belum efektif karena penggunaan media pembelajaran belum sesuai dengan karakteristik dan usia anak didik. Media poster gambar dua dimensi menyajikan ilustrasi melalui gambar yang hampir menyerupai kenyataan dari suatu objek atau situasi sehingga mudah diingat secara visualisasi membantu anak memahami dan mengingat cerita dengan lebih baik. Penelitian ini bertujuan untuk meningkatkan kemampuan bercerita pada anak usia 5-6 tahun melalui penggunaan media poster gambar dua dimensi. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan teknik pengumpulan data melalui wawancara terstruktur, observasi langsung, dan dokumentasi. Hasil penelitian yaitu peran guru sebagai fasilitator mampu menciptakan pembelajaran yang dinamis, partisipatif, dan bermakna. Ketersediaan media pembelajaran poster gambar dua dimensi dapat membantu anak berpartisipasi secara kreatif dalam meningkatan kreativitas, penguasaan struktur kosakata cerita, berekspresi, dan mampu mengembangkan emosi ekplorasi anak di dalam belajar. Media ini sangat efektif membantu meningkatkan kemampuan bercerita anak usia 5-6 tahun di TK Aisyiyah Bustanul Athfal, namun harus didukung oleh pemahaman yang baik dan latihan berkelanjutan secara berkala, sehingga kemampuan bercerita dapat berkembang sesuai kemampuan berbahasa masing-masing anak.
FATORES DETERMINANTES NA ESCOLHA DOS DISJUNTORES DE HAAS E HYRAX E OS ASPECTOS PSICOLÓGICOS ENVOLVIDOS: REVISÃO DE LITERATURA
Authors: Lima Daniel Ferraz , Costa Olga Pereira Bizerra da , Souza Vanessa Vitória Oliveira , Nóbrega Anne Marcely Ramos da , Guimarães Anna Beatriz Andrade 
Published: December 2024

Introdução: Os disjuntores na ortodontia desempenham um papel vital na busca pela harmonia e funcionalidade do sorriso. São dispositivos hábeis que, com sua capacidade de expandir o arco dentário, não apenas promovem a estética facial, que surge como problemática a pacientes que necessitam do uso de tais aparelhos, mas também proporcionam uma base sólida de pesquisas diferenciando-os. Objetivo: O intuito deste estudo será discutir as particularidades e a aplicação dos disjuntores Haas e Hyrax no tratamento de mordida cruzada em crianças e pré-adolescentes, além de investigar o impacto psicossocial. Resultados esperados: Os resultados dessa pesquisa podem favorecer para o conhecimento sobre os disjuntores de Hyrax e Haas bem como os aspectos psicosssociais relacionados a pacientes que fazem uso desses aparelhos, oferecendo novas perspectivas, confirmando ou contradizendo hipóteses, por meio de pesquisas e dados coletados.
“HELP” : TEKNIK DAN IMPLEMENTASI DALAM PROGRAM APLIKASI DAN MULTIMEDIA
Authors: Joko Prasetyo Hendro , Muryanto  
Published: December 2024

Tujuan penelitian ini adalah untuk menunjukkan dan membuktikan bahwa membuat system online help itu adalah tidak sulit dengan membuat program aplikasi kita dapat merancang dan membuat sendiri system HTML help dan mengintegrasikannya ke program aplikasi yang kita buat. Karena saat kita membuat program aplikasi, biasanya akan disertai dengan program aplikasi fasilitas help, sehingga pengguna aplikasi akan bisa menggunakan aplikasi yang kita buat sesuai dengan harapan. Disisi lain fungsi dari system help ini adalah sebagai sarana belajar untuk menjadikan fasilitas help ini menjadi media interaktif yang diharapkan akan dapat membantu pada saat user menggunakan program aplikasi yang kita buat khususnya jika ada kesalahan pada saat menggunakannya.
Metodologi yang digunakan dalam pembuatan fasilitas help ini adalah dengan menggunakan metoda observasi dan membaca berbagai literature baik buku maupun dengan membaca media yang berkaitan dengan pembuatan media help di internet . pembuatan system help, akan membutuhkan pengetahuan dasar membuat file HTML ( Hypertext Markup Language). Karena format ini adalah fondasi utama dalam pembuatan system HTML Help, juga dengan sedikit kreatifitas dalam urusan tata letak dan diseain, sehingga tampilan akan tidak membosankan yang akan membuat penggunaka betah dalam membacanya.
Hasil penelitian ini menunjukkan bahwa membuat system on line help sangatlah mudah. Tidak diperlukan syarat harus mengerti bahasa pemprograman dan dengan menggunakan help sebagai media interaktif ternyata dapat membuat pengguna lebih mudah memahami siswa dalam memahami apa yang menjadi tujuan belajarnya. Karena system help berformat multimedia, dimana gambar, suara dan animasi bisa dipadukan menjadi satu kesatuan.

Kata Kunci : Fasilitas Help, HTML,Multimedia Animasi
Genomic Insights into Rheumatoid Arthritis through computational Profiling for Hub Genes
Authors: Sushma Thandal Anantharaman  , Alex Anand Daniel , Athista Manoharan  , Swetha Sunkar  
Published: December 2024

Rheumatoid arthritis (RA) is a complex autoimmune disorder predominantly affecting joints, with its etiology and response to treatment still not fully understood despite extensive historical documentation. This study aims to shed light on the differentially expressed genes (DEGs) associated with RA progression, potentially identifying new drug targets and management strategies. This study analyzed gene expression data (GSE193193) from the Gene Expression Omnibus (GEO) database, identifying 3672 significant DEGs out of 36107 initially retrieved genes. Among these, 283 genes were up-regulated and 360 were down-regulated. Gene enrichment analysis was performed to uncover relevant gene ontology terms and pathways. Subsequently, network construction and analysis, along with hub gene prediction using Cytoscape's MCODE and CytoHubba plugins, were conducted. Key genes identified in this study include HBB, ALAS2, GATA1, AHSP, HBG1, HBG2, HBD, KLF1, SLC4A1, EPB42, ZMYND10, DNAJC7, HYDIN, LRRC6, FN1, NCAM1, FASLG, CTCF, SMAD4, and STAT1. These genes are implicated not only in RA but also in other diseases, presenting them as potential therapeutic targets. Additionally, three transcription factors (GATA1, NFKB1, and RELA) and one miRNA (has-mir-27a-3p) were identified as key regulators of these hub genes. In conclusion, this study not only enhances our understanding of the molecular mechanisms underlying RA but also identifies several critical DEGs and regulatory factors that could serve as promising targets for therapeutic intervention. The identification of these genes and regulatory elements paves the way for the development of targeted treatments, which could significantly improve disease management and patient outcomes. Future research focusing on these identified targets may lead to innovative strategies for combating RA and potentially other autoimmune disorders, thereby offering new hope to patients affected by these conditions.
COMPARISON OF VAGAL MANEUVERS VS VERAPAMIL FOR CARDIOVERSION OF ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA. A COMPARATIVE CROSS SECTIONAL STUDY
Authors: Hadi Noor ul , Asfandiyar  , Ullah Ikram , Shah Syed Tahir , Ahmad Farooq , Rahman Abdur , Ahmad Mushataq 
Published: December 2024

Background: Vagal Maneuver is an underutilized strategy for Cardioversion of Atrioventricular nodal reentrant tachycardia. The present study is an attempt to explore the effectiveness of this strategy. Methods: This comparative cross-sectional study was performed at the Department of Cardiology MTI MMC Mardan from the first January 2017 to 31 December 2019. Patients with Palpitations and having documented AVNRT on ECG were selected for this study. Patients were divided into two groups, i.e., Group A and Group B through envelope method. Patients in Group A were subjected to vagal maneuvers like carotid sinus massage, and Valsalva methods. Patients in Group B received injection verapamil 5 mg. Results: A sample size of 100 patients were enrolled. The mean age was 31 with 8.6SD. Male were 54% and females were 46%. The success rate of vagal maneuvers in group A was 36% (n=18), while in group B, it was 84% (n=42) for verapamil (36% vs 84%, p-value<0.001, highly significant). In group A, time for cardioversion in less than 2 minutes was 68%. While in group B, the time for cardioversion in less than two minutes was 12%. ( 68% vs 12%, p<0.001, highly significant).Cross over in Group A was 64% (n=32) to verapamil. While in group B, this was 6% (n=3) to DC shock and 14% (n=7) to vagal maneuvers (64% vs 18%, p<0.001, highly significant.) Conclusion: Simple Valsalva Maneuvers and verapamil proved to be effective in cardioversion of SVT/AVNRT. Both are safe. Verapamil is more successful in cardioversion as compared to Valsalva maneuvers.
MACROGLOSSIA ASSOCIATED WITH PRIMARY SYSTEMIC AMYLOIDOSIS - CASE REPORT WITH UNUSUAL CLINICAL PRESENTATION
Authors: Suriyakala M  , Leela Sreekantan Nair Sreela  , Philips Mathew  , Twinkle S Prasad  , Admaja K Nair  , Merrin Jose  
Published: December 2024

Amyloidosis is characterised by the deposition of fibrillar insoluble proteinaceous material called amyloid in the extracellular spaces. It may present as localized form which is rare and systemic form. Systemic amyloidosis involves many organs like kidney, heart and liver. Manifestations of both types may vary based on the age of onset, degree and extension of the deposition. Understandably, the diagnosis is challenging but the early identification of the condition and the type of amyloidosis can increase the efficiency of treatment. Positive Congo red staining is the gold standard for demonstration of amyloid in tissue sections. Here we are presenting a case of a 77-year-old female patient who presented with the complaint of difficulty in swallowing for 2 years due to bilateral symmetrical enlargement of the tongue which was subsequently diagnosed as systemic amyloidosis.
THORACIC EPIDURAL VERSUS GENERAL ANAESTHESIA FOR LAPAROSCOPIC CHOLECYSTECTOMY: A RANDOMIZED CONTROLLED TRIAL
Authors: Ahmad Fariha , Liaquat Ali  , Madiha Ahmed  , Mohammed Yasrab  , Arshad Khusdil  , Samiullah  
Published: December 2024

Background: Laparoscopic cholecystectomy is one of the most commonly performed surgeries worldwide. Aim of our study was to compare the effectiveness of thoracic epidural anaesthesia with general anaesthesia for Laparoscopic cholecystectomy in terms of changes in blood pressure during surgery, postoperative pain, respiratory complications and average length of hospital stay. It was a randomized controlled trial conducted from 1stOctober 2018 to 31st October 2019. Methods: Eighty-two patients planned to undergo elective laparoscopic cholecystectomy were randomly divided into two groups, T and G. In Group T all patients underwent laparoscopic cholecystectomy under thoracic epidural anaesthesia with 12 ml of 0.25% bupivacaine and 1% lignocaine plain whereas in group G all patients underwent surgery under general anaesthesia. Intra-operative mean arterial pressure (MAP) and postoperative opioid consumption in first 24hrs were recorded as primary outcomes whereas presence or absence of respiratory complication and duration of hospital stay as secondary outcome. Results: Out of 82 patients, 41 patients underwent laparoscopic cholecystectomy under thoracic epidural anaesthesia and 41 patients had surgery under general anaesthesia. Mean arterial pressure was lower in Group T and the difference was statistically significant. The average time of first complaint of postoperative pain in Group T was 5.4±1.26 hours as compared to less than 0.79±0.25 hours in Group G. Patients in group T required lower doses of opioid analgesia in first twenty-four hours as compared to patients in group G. Mean hospital stay in group T was 1 day as compared to 3 days in group G. Conclusion: Thoracic epidural anaesthesia provides a better alternative to general anaesthesia for Laparoscopic cholecystectomy with lower intraoperative mean arterial blood pressure, 24 hours postoperative consumption of opioids, respiratory complications and length of hospital stay.
ASSOCIATION OF THYROID FUNCTION TEST WITH POST-COVID-19 PCR-NEGATIVE PATIENTS
Authors: Abid Ali Khawaj  , Sabahat Asghar  , Samman Khurshid  , Noreen Taj  , Rubina Faisal Paul  , Fozia Jehangir  
Published: December 2024

Background: Corona virus diseases-19 (COVID-19) infection has shown many complications in all organ systems, like thyroid gland, during the acute phase and in the post-COVID-19 period. The aim of this study was to find the risk of hypo-functioning thyroid gland during post COVID-19 period as a chronic complication for possible follow up and management implications. Methods: This combined retrospective-prospective study was conducted over a period of nine months at tertiary care hospitals, Ayub Medical Complex Abbottabad and King Abdullah Hospital, Mansehra. Through non-probability convenient sampling technique, data was collected from 160 records at the hospitals. Confirmed cases of COVID-19, after their consent, were measured for thyroid hormones at two, four and eight weeks. Data was analyzed using Chi-square test. p-value less than 0.05 was considered as significant. Results: Out of 160 study participants, majority 102 (63.75%) were males and 58 (36.25%) were females with mean age of study population of 47.41±14.29 years. The frequency of hypothyroidism decreased over eight weeks from 8 (38.09%) to 6 (28.57%). While subclinical hypothyroidism decreased from 14 (36.89%) to 12 (30.76%). There was a very highly significant (p= 0.0001) association between proportions of hypothyroidism, Euthyroid Sick Syndrome and Subclinical hypothyroidism, and proportions of euthyroid patients in post COVID-19 period over eight weeks. Conclusion: Subclinical hypothyroidism, overt hypothyroidism, Euthyroid Sick Syndrome, and thyrotoxicosis are manifestations of hypo functioning thyroid gland. There is a need to monitor patients over a period of as short as two weeks to two months and beyond for possible detection of these complications of COVID-19 for appropriate management.
Дистанционное обучение: история становления и современные тенденции в образовательном пространстве
Authors: Фрик О.В. 
Published: December 2024

Стремительное развитие информационных технологий и, в частности, возможностей искусственного интеллекта актуализирует изучение истории становления дистанционного обучения и определение современных тенденций его развития. В статье проанализированы основные этапы становления дистанционного обучения, ситуация с терминологией, особенности современного этапа дистанционного обучения и его формы. Автором подчёркивается роль пандемии коронавируса в развитии дистанционного обучения. Делается вывод о том, что сегодня дистанционное обучение перестало быть обособленным феноменом – дистанционные технологии прочно вошли в процессы обучения на разных уровнях и стали их неотъемлемой составляющей.
The rapid development of information technology and, in particular, the capabilities of artificial intelligence actualizes the study of the history of the development of distance learning and the definition of modern trends in its development. The article analyzes the main stages of the development of distance learning, the situation with terminology, the features of the current stage of distance learning and its forms. The author emphasizes the role of the coronavirus pandemic in the development of distance learning. It is concluded that today distance learning has ceased to be an isolated phenomenon – distance technologies have firmly entered the learning processes at different levels and have become their integral part.
О роли учебной дисциплины «Основы российской государственности» в идеологическом образовании и гражданско-патриотическом воспитании в вузе
Authors: Фрик О.В. 
Published: December 2024

В статье обсуждается значимость включения модуля «Основы российской государственности» в образовательные программы высших учебных заведений по всем направлениям подготовки бакалавриата и специалитета в качестве дисциплины базовой части. Автором представлены результаты исследования научных и методических статей, посвящённых данной дисциплине. Особое внимание уделяется воспитательному и идеологическому контексту, так как осознанный патриотизм всегда основан на знании. Рассматриваемая дисциплина призвана дать обучающимся целостное представление о России как самобытном государстве-цивилизации. Она акцентирует внимание на создании духовно-нравственной базы, необходимой для формирования полноценной личности с осознанием исторического пути России. В ходе обсуждения проанализированы следующие вопросы: условия появления курса и его актуальность, нормативно-правовая база курса, основные содержательные элементы курса, его базовые категории, комплексный характер и ярко-выраженная мировоззренческая направленность. В заключении подчёркивается, что новая дисциплина «Основы российской государственности» призвана сформировать у российской молодёжи уверенность в её будущем в России, суверенном, сильном, социальном государстве, самобытном государстве-цивилизации.
The article discusses the importance of including the module "Fundamentals of Russian Statehood" in the educational programs of higher education institutions in all areas of bachelor's and specialist's degrees as a discipline of the basic part. The author presents the results of the study of scientific and methodological articles devoted to this discipline. Particular attention is paid to the educational and ideological context, since conscious patriotism is always based on knowledge. The discipline under consideration is designed to give students a holistic understanding of Russia as an original state-civilization. It focuses on the creation of a spiritual and moral base necessary for the formation of a full-fledged personality with an awareness of the historical path of Russia. During the discussion, the following issues were analyzed: the conditions for the emergence of the course and its relevance, the regulatory framework of the course, the main substantive elements of the course, its basic categories, complex nature and pronounced ideological orientation. In conclusion, it is emphasized that the new discipline “Fundamentals of Russian Statehood” is designed to instill confidence in Russian youth in their future in Russia, a sovereign, strong, social state, an original state-civilization.
A percepção do risco e a intenção de compra durante a pandemia do COVID-19
Authors: Silva-Oliveira Keilla Dayane da , Avelar Aline Bento Ambrósio 
Published: December 2024

Objetivo: Verificar a influência da percepção de risco do COVID-19 e a intenção de compra presencial mediado pelas dimensões do modelo TCP estendido.
Método: A pesquisa é classificada como descritiva com abordagem quantitativa com a participação de 596 consumidores. A técnica utilizada foi a de Modelagem de Equações Estruturais, com o uso do SmartPLS versão 3.
Originalidade/Relevância: Esta pesquisa incorporou o medo antecipado ao modelo TCP para construir um modelo estendido. O modelo TCP estendido auxilia a realização de uma análise abrangente e faz entender melhor a intenção de compra dos consumidores durante a pandemia do COVID-19.
Resultados: Os resultados mostraram que a percepção de risco do COVID-19 influencia negativamente os elementos do modelo TCP e positivamente o medo antecipado. Constatou-se também que a atitude, a norma subjetiva e o controle do comportamento percebido tem um impacto positivo na intenção de compra. Portanto, os antecedentes do modelo TCP exercem a função de mediação na relação entre a percepção de risco do Covid-19 e a intenção de compra, porém o medo antecipado não possui nenhuma influência.
Contribuições teóricas/metodológicas: A contribuição teórica do estudo se refere a observação de como a percepção do risco da COVID-19 influenciou a intenção de compra por meio do modelo TCP.
Contribuições para a gestão: As descobertas podem contribuir para a compreensão do comportamento dos consumidores durante uma pandemia e ajudar o governo e a área de marketing a tomar medidas para reduzir as perdas.
Clinician experiences of a hybrid virtual medical service supporting rural and remote hospitals: a qualitative study
Authors: Thompson Anna E , Saurman Emily , Nott Shannon , Wilson Andrew , Shaw Tim 
Published: December 2024

AbstractObjectivesTo explore the experiences of clinicians delivering, facilitating, and potentially affected by a hybrid virtual medical model servicing rural and remote hospitals in western New South Wales.Design, setting, participantsQualitative study using semi‐structured focus groups and individual interviews, conducted between 7 April 2022 and 16 March 2023, with rural generalist doctors delivering the Virtual Rural Generalist Service (VRGS) within the Western NSW Local Health District, local site staff, and local general practitioner visiting medical officers (GP VMOs).Main outcome measuresKey themes in clinician experience of the model and recommendations for improved experience, based on qualitative content analysis.ResultsWe interviewed 12 VRGS doctors, 25 site nursing staff and nine GP VMOs. Clinicians were overwhelmingly positive about the VRGS, seeing it as providing good quality care and being an innovative and translatable solution to rural workforce challenges. In‐person site visits by VRGS doctors were highly valued, especially by local site staff, for team building, skill building and increasing VRGS doctors’ understanding of the local context. The VRGS model relies on nursing availability and skill, and creates additional workload for nurses. Nurses in isolated sites valued the clinical support provided by the VRGS. Overall, most GP VMOs valued the fatigue relief offered by the VRGS; however, some viewed the VRGS as diminishing local doctors’ autonomy and the viability of their positions.ConclusionsThe hybrid VRGS model is widely accepted by clinicians as providing good quality care for patients and high job satisfaction for providers. The service supports the local health workforce and makes rural medical positions more attractive and sustainable. The in‐person shift requirement is central to the model's effectiveness and acceptability. Further investment is needed to train and resource local nurses who play an integral role in providing virtual medical care.