bluuebunny/crossref_metadata_2025_split huggingface dataset:
The joint evolution of lifespan and self‐fertilization
Authors: Lesaffre Thomas , Billiard Sylvain 
Published: September 2019

AbstractIn Angiosperms, there exists a strong association between mating system and lifespan. Most self‐fertilizing species are short‐lived, and most predominant or obligate outcrossers are long‐lived. This association is generally explained by the influence of lifespan on the evolution of the mating system, considering lifespan as fixed. Yet, lifespan can itself evolve, and the mating system may as well influence the evolution of lifespan, as is suggested by joint evolutionary shifts of lifespan and mating system between sister species. In this paper, we build modifier models to study the joint evolution of self‐fertilization and lifespan, including both juvenile and adult inbreeding depression. We show that provided that inbreeding depression affects adult survival, self‐fertilization is expected to promote evolution towards shorter lifespan, and that the range of conditions under which selfing can evolve rapidly shrinks as lifespan increases. We study the effects of inbreeding depression affecting various steps in the life cycle and discuss how extrinsic mortality conditions are expected to affect evolutionary associations. In particular, we show that selfers may sometimes remain short‐lived even in a very stable habitat, as a strategy to avoid the deleterious effects of inbreeding.
Why academics should study the supply chains of individual corporations
Authors: Goldstein Benjamin , Newell Joshua P. 
Published: September 2019

AbstractAlthough fields such as industrial ecology have advanced our understanding of how cleaner technologies, recycling, and lifestyle changes can reduce the impacts of production and consumption on people and planet, environmental deterioration and social injustices stubbornly persist. New strategies are needed to achieve change in an era of increasing urgency. This paper proposes that academics study the supply chains of individual corporations and link them to environmental and social impacts in geographically specific areas. Nongovernmental organizations (NGOs) have used this approach successfully, issuing reports about corporate activity related to deforestation, sweatshops, and other issues of social concern. But academics, by and large, have studied generic products, industries, and sectors. To verify this, after reviewing approximately 11,000 studies on supply chains, we identified just 27 academic papers that focused on individual corporations. These were primarily by NGOs and social scientists, with no studies by industrial ecologists meeting our review criteria. To uncover corporate supply chains, researchers used two distinct methodological approaches: in situ (interviews, surveys, and surveillance) and ex situ (trade data, document analysis, and maps). In this paper, we explain why and how academics should study the supply chains of individual corporations. This is done by combining approaches from industrial ecology, with those from geography, sociology, and other social sciences to develop a political‐industrial ecology of supply chains. This both physically links actual product flows with their environmental impacts, and explores how they affect justice, equity, and welfare. The work we propose offers clear collaborative linkages with NGOs, industry, and the media.
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
Authors: Grimm Amandine , Lejri Imane , Hallé François , Schmitt Martine , Götz Jürgen , Bihel Frederic , Eckert Anne 
Published: September 2019

AbstractTranslocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis. TSPO modulation also appears to play a role in other mitochondrial functions, including mitochondrial respiration and cell survival. In the central nervous system, its expression is up‐regulated in neuropathology such as Alzheimer's disease (AD). Previously, we demonstrated that two new TSPO ligands, named 2a and 2b, stimulated pregnenolone synthesis and ATP production in a cellular model of AD overproducing β‐amyloid peptide. The present study aimed to evaluate the impact of the new TSPO ligands on mitochondrial dysfunction in a cellular model of AD‐related tauopathy (human neuroblastoma cells SH‐SY5Y stably overexpressing the P301L‐mutant Tau) presenting mitochondrial impairments, including a decreased ATP synthesis and mitochondrial membrane potential, as well as a decrease in pregnenolone synthesis compared to control cells. The effects of our new ligands were compared with those of TSPO ligands described in the literature (XBD173, SSR‐180,575 and Ro5‐4864). The TSPO ligands 2a and 2b exerted beneficial mitochondrial modulatory effects by increasing ATP levels and mitochondrial membrane potential, paralleled by an increase of pregnenolone levels in mutant Tau cells, as well as in control cells. The compounds 2a and 2b showed effects on mitochondrial activity similar to those obtained with the TSPO ligands of reference. These findings indicate that the new TSPO ligands modulate the mitochondrial bioenergetic phenotype as well as the de novo synthesis of neurosteroids in a cellular model of AD‐related tauopathy, suggesting that these compounds could be potential new therapeutic tools for the treatment of AD.
Pathways to Power: The Role of Preparliamentary Careers and Political Human Capital in the Obtainment of Cabinet Positions
Authors: Turner‐Zwinkels Tomas , Mills Melinda C. 
Published: September 2019

Understanding the rise to power is central to the study of politics. Yet, we still know little about the career paths of influential politicians like ministers. The literature assumes that dominant preparliamentary occupations (e.g., lawyer, local offices) predict promotion. We move beyond this potential ecological fallacy and suggest a perspective that emphasizes the role of gatekeepers and political human capital like national political experience and education. We leverage complete career data of all Dutch MPs (N = 1,263; 1945–2012) and study their (N = 4,966) opportunities to obtain a cabinet position. A sequence analysis with fuzzy clustering reveals eight career paths in both the professional and political domain. A logistic regression analysis that uses these career paths as predictors shows that prominent occupations and communicative experience do not constitute the pathway to ministerial power; a university education and preparliamentary national political experience do. Findings support the value of political human‐capital theory to understand political promotion.
Evolutionary processes from the perspective of flowering time diversity
Authors: Gaudinier Allison , Blackman Benjamin K. 
Published: September 2019

SummaryAlthough it is well appreciated that genetic studies of flowering time regulation have led to fundamental advances in the fields of molecular and developmental biology, the ways in which genetic studies of flowering time diversity have enriched the field of evolutionary biology have received less attention despite often being equally profound. Because flowering time is a complex, environmentally responsive trait that has critical impacts on plant fitness, crop yield, and reproductive isolation, research into the genetic architecture and molecular basis of its evolution continues to yield novel insights into our understanding of domestication, adaptation, and speciation. For instance, recent studies of flowering time variation have reconstructed how, when, and where polygenic evolution of phenotypic plasticity proceeded from standing variation and de novo mutations; shown how antagonistic pleiotropy and temporally varying selection maintain polymorphisms in natural populations; and provided important case studies of how assortative mating can evolve and facilitate speciation with gene flow. In addition, functional studies have built detailed regulatory networks for this trait in diverse taxa, leading to new knowledge about how and why developmental pathways are rewired and elaborated through evolutionary time.
JC polyomavirus‐specific antibody responses in pediatric kidney transplant recipients
Authors: Ylinen Elisa , Miettinen Jenni , Jalanko Hannu , Weissbach Fabian H. , Tainio Juuso , Wernli Marion , Lautenschlager Irmeli , Hirsch Hans H. 
Published: September 2019

AbstractBKPyV is widely recognized in KTRs, but little is known about rates of primary and secondary JCPyV exposure in pediatric KTRs. We evaluated JCPyV exposure in pediatric KTRs using antibody responses in the first 12 months post‐transplant. Of 46 children transplanted between 2009 and 2014, 6 lacked any samples for serologic testing, leaving 40 KTRs for study. JCPyV‐specific IgG and IgM antibodies were measured using a normalized VLP ELISA. Significant JCPyV exposure was defined as IgG seroconversion, increasing IgG levels of >0.5 nOD units, or IgM detection. Of 40 recipients (median age 3.2 years), 11 (27.5%) were seropositive, 20 (50%) seronegative for JCPyV‐IgG, while 9 (22.5%) had no specimen at the time of transplantation, but were confirmed as seronegative in post‐transplant samples. Of 29 (72.5%) at risk, JCPyV‐IgG seroconversion occurred in 15/29 (51.7%) including JCPyV‐IgM in 6 patients (20.7%). Two patients (6.9%) developed only JCPyV‐IgM. Among JCPyV‐IgG‐positive KTRs, six (12.5%) had significant IgG increases. Altogether 23 of 40 patients (57.5%) had serological evidence of primary or secondary JCPyV exposure. In these patients, kidney function tended to be lower during the 2 years of follow‐up, but only one patient lost the graft due to JCPyV nephropathy. Thus, JCPyV exposure is common in pediatric KTR and may present serologically as primary or secondary infection. Although only one case of JC‐PyVAN occurred, a trend toward lower renal function was seen. Dedicated studies of larger cohorts are warranted to define impact of JCPyV in pediatric KTR.
Optimizing assessments of post‐error slowing: A neurobehavioral investigation of a flanker task
Authors: Schroder Hans S. , Nickels Stefanie , Cardenas Emilia , Breiger Micah , Perlo Sarah , Pizzagalli Diego A. 
Published: September 2019

AbstractAppropriately adjusting to errors is essential for adaptive behavior. Post‐error slowing (PES) refers to the increased reaction times on trials following incorrect relative to correct responses. PES has been used as a metric of cognitive control in basic cognitive neuroscience research as well as clinical contexts. However, calculation of PES varies widely among studies and has not yet been standardized, despite recent calls to optimize its measurement. Here, using behavioral and electrophysiological data from a modified flanker task, we considered different methods of calculating PES, assessed their internal consistency, examined their convergent correlations with behavioral performance and error‐related event‐related brain potentials (ERPs), and evaluated their sensitivity to task demands (e.g., presence of trial‐to‐trial feedback). Results indicated that the so‐called robust measure of PES, calculated using only error‐surrounding trials, provided an estimate of PES that was three times larger in magnitude than the traditional calculation. This robust PES correlated with the amplitude of the error positivity (Pe), an index of attention allocation to errors, just as well as the traditional method. However, all PES estimates had very weak internal consistency. Implications for measurement are discussed.
Numerical Investigation of Unsteady Multiphase Nanofluid-Free Convection Flow About a Vertical Cylinder With Non-Uniform Temperature
Authors: Narahari Marneni , Suresh Kumar Raju S. , Pendyala Rajashekhar , Ilyas Suhaib Umer 
Published: September 2019

Abstract
A numerical investigation on the transient-free convection flow of the multiphase nanofluid past a vertical cylinder, which has a power-law variation surface temperature along with the height, is presented. The problem has typical engineering applications involving cooling of vertical cylindrical rods in mechanical/manufacturing systems, cooling of nuclear reactors, and the design of other advanced cooling technologies. Buongiorno’s model is applied in this research, which incorporates thermophoresis and Brownian diffusion effects of nanoparticles. The zero-volume flux condition is implemented for nanoparticle concentration at the boundary to obtain realistic results. A robust second-order accurate finite-difference scheme of Crank–Nicolson type is applied to tackle the system of coupled non-linear partial differential equations numerically. The impacts of time, variable surface temperature power-law exponent, Brownian and thermophoresis parameters are investigated on nanofluid flow and heat transfer aspects. The decisive finding suggests that the effect of the power-law exponent of the variable wall temperature is to reduce the nanoparticle relocation, velocity, and temperature in the nanofluid boundary layer causing the heat transfer enhancement. The skin-friction decreased significantly with the rise of the power-law exponent of the wall temperature. The present numerical scheme is corroborated by comparing the average skin-friction results with the available literature for clear fluid.
A Two-Dimensional Adjustable Constant-Force Mechanism
Authors: Kuo Yu-Ling , Lan Chao-Chieh 
Published: September 2019

Abstract
Constant-force mechanisms (CFMs) can produce an almost invariant output force over a limited range of input displacement. Without using additional sensor and force controller, adjustable CFMs can passively produce an adjustable constant output force to interact with the working environment. In the literature, one-dimensional CFMs have been developed for various applications. This paper presents the design of a novel CFM that can produce adjustable constant force in two dimensions. Because an adjustable constant force can be produced in each radial direction, the proposed adjustable CFM can be used in applications that require two-dimensional force regulation. In this paper, the design formulation and simulation results are presented and discussed. Equations to minimize the output force variation are given to choose the design parameters optimally. A prototype of the two-dimensional CFM is tested to demonstrate the effectiveness and accuracy of adjustable force regulation. This novel CFM is expected to be used in machines or robots to interact friendly with the environment.
Using Graphs to Link Data Across the Product Lifecycle for Enabling Smart Manufacturing Digital Threads
Authors: Hedberg Thomas D. , Bajaj Manas , Camelio Jaime A. 
Published: September 2019

Abstract
Smart manufacturing promises to provide significant increases in productivity and effectiveness of manufacturing systems by better connecting the data from people, processes, and things. However, there is no uniform, generalized method for deploying linked-data concepts to the manufacturing domain. The literature describes and commercial vendors offer centralized data-repository solutions, but these types of approaches quickly breakdown under the intense burden of managing and reconciling all the data flowing in and out of the various repositories across the product lifecycle. In this paper, we introduce a method for linking and tracing data throughout the product lifecycle using graphs to form digital threads. We describe a prototype implementation of the method and a case study to demonstrate an information round-trip for a product assembly between the design, manufacturing, and quality domains of the product lifecycle. The expected impact from this novel, standards-based, linked-data method is the ability to use digital threads to provide data, system, and viewpoint interoperability in the deployment of smart manufacturing to realize industry’s $30 Billion annual opportunity.
Primary dysmenorrhea and self-care strategies among Chinese college girls: a cross-sectional study
Authors: Chen Ling , Tang Lu , Guo Shengyu , Kaminga Atipatsa Chiwanda , Xu Huilan 
Published: September 2019

ObjectivesTo explore the prevalence of primary dysmenorrhea (PD), the characteristics of PD and self-care strategies for managing PD among Chinese college girls.DesignCross-sectional study.SettingChangsha, China.ParticipantsA total of 2555 college girls were recruited using multistage cluster random sampling.Outcome measuresA self-report questionnaire was used to measure sociodemographic information, characteristics of PD and self-care strategies for managing PD. Additionally, a Visual Analogue Scale was used to measure pain severity.ResultsOf the 2555 girls, 1306 had experienced PD, representing a 51.1% prevalence. In addition, the prevalence rates of mild, moderate and severe pain in PD were 18.1%, 27.7% and 5.4%, respectively. The most common symptoms associated with PD were cramps (96.9%), weakness (70.0%), backache (65.1%), facial blemishes (55.3%) and irritability (55.3%). Commonly used self-care strategies for managing PD comprised reducing physical activity (94.6%), keeping warm (84.6%), communicating dysmenorrhea with friends or classmates (79.0%), drinking warm beverages (75.7%) and avoiding cold drinks and foods (74.2%). In addition, only 34.8% self-medicated with Western medicine (15.6%), traditional Chinese medicine (8.6%), or both (10.6%). Medical advice was sought by 27.4% of subjects from a Western medical doctor (10.3%), a doctor of traditional Chinese medicine (13.6%), or both (3.5%). Girls who had greater pain severity were more likely to be self-medicated (OR=7.01; 95% CI 4.50 to 10.91), use complementary therapies (OR=2.64; 95% CI 1.70 to 4.10) and seek medical advice (OR=5.93; 95% CI 3.80 to 9.24).ConclusionsPD is highly prevalent among Chinese college girls, with a high burden of symptoms. In addition, these girls are most likely to change their lifestyle, communicate dysmenorrhea with friends or mothers, use heat therapy and engage in self-talk, but less likely to self-medicate or seek medical advice for managing PD.
Effects of one week different intensity endurance exercise on cardiorespiratory and cardiometabolic markers in junior young athletes
Authors: Tesema Gashaw , George Mala , Mondal Soumitra , Mathivana D 
Published: September 2019

BackgroundEndurance training in varied intensity zones are more likely to show different adaptive responses. However, it is still unclear the intensity level of endurance exercise in junior young athletes that may promote increased markers for cardiorespiratory and cardiometabolic response. Therefore, we aimed to investigate the effect of 1 week different intensity endurance training on markers of cardiorespiratory and cardiometabolic response in young athletes.MethodsThirty apparently healthy male young athletes averaging 19.4±1.3 years of age were recruited and randomly assigned to two different intensity endurance training groups. The first group trained at 60% to 70% maximum heart rate (HRmax) for 45 min per session and the second group trained at 70% to 80% HRmax for 30 min per session for a period of 1 week three sessions per week. A pre-training and post-training, marker of cardiorespiratory and cardiometabolic response was assessed for both groups.ResultsBoth intensity training had no significant effect on markers of cardiorespiratory response within and between training groups (p>0.05). Whereas, cardiometabolic markers lactate dehydrogenase (p=0.001), cardiac troponin I (p=0.001) and creatine kinase myocardial band (p=0.001) significantly increased at the end of 1 week within the group in both training groups (p≤0. 05). In the comparative analysis between groups, there was no significant difference in markers of cardiometabolic response (p>0.05).Conclusion1 week 60% to 70% HRmax and 70% to 80% HRmax intensity zones induces similar acute effects on markers for cardiometabolic and cardiorespiratory responses between groups and significant elevations of cardiometabolic markers within the groups in moderately trained young athletes.
Evaluation of the effect of β-mannanase supplementation and mannans on nursery pig growth performance and serum acute-phase protein concentrations
Authors: Huntley Nichole F. , Gould Stacie A. , Patience John F. 
Published: September 2019

The objective was to evaluate the effects of dietary mannan and β-mannanase supplementation on growth performance and serum acute-phase proteins in nursery pigs. Pigs (n = 480) were blocked by initial body weight (6.6 ± 0.4 kg), and 12 pens per treatment were randomly assigned to one of four treatments in a 2 × 2 factorial arrangement for 28 d. Two levels of dietary mannan (0.4% vs. 2.8%) were offered with and without 0.05% endo-1,4-β-mannanase. Serum was collected (one pig per pen) for haptoglobin and C-reactive protein (CRP) analysis on days 0 and 28. There were no significant interactions between mannan level and β-mannanase supplementation. High-mannan diet decreased average daily gain (P = 0.027) and average daily feed intake (P = 0.024) compared with low-mannan diets with no effect of β-mannanase (P > 0.10). Haptoglobin and CRP were not affected by mannan level or β-mannanase supplementation (P ≥ 0.160). Therefore, dietary β-mannans as high as 2.8% did not induce a systemic innate immune response. Thus, the levels of β-mannan found in practical diets (<2%) are unlikely to induce an immune response; therefore, supplementation of β-mannanase to avoid this response is not warranted.
Dynamical and thermal stabilities of nonlinearly charged AdS black holes
Authors: Sajadi S. N. , Riazi N. , Hendi S. H. 
Published: September 2019

Abstract
In this paper, we study an extended phase space thermodynamics of a nonlinearly charged AdS black hole. We examine both the local and global stabilities, and possible phase transition of the black hole solutions. Finally, we compute quasi-normal modes via scalar perturbations and compare the obtained results with those of Reissner-Nordström black hole.
Operational Accepting State Complexity: The Unary and Finite Case
Authors: Dassow Jürgen 
Published: September 2019

Let [Formula: see text] be the minimal number of accepting states which is sufficient for deterministic finite automata to accept [Formula: see text]. For a number [Formula: see text] and an [Formula: see text]-ary regularity preserving operation ∘, we define [Formula: see text] as the set of all integers [Formula: see text] such that there are [Formula: see text] languages [Formula: see text], [Formula: see text], with [Formula: see text] In this paper, we study these sets for the operations union, catenation, star, complement, set-subtraction, and intersection where we restrict to unary or finite or unary and finite languages [Formula: see text].