bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a conceptual framework of knowledge management
Authors: Farooq Rayees 
Published: December 2018

Purpose
Knowledge management is a function of learning orientation, knowledge sharing, organizational memory and knowledge reuse. This paper aims to endeavor to explore a link between knowledge management and value creation which seem to be fragmented in the literature due to various conceptualizations and meanings. The study hypothesized a moderating role of social capital on the relationship between knowledge management and value creation.

Design/methodology/approach
The study was approached from the theoretical perspective. Study thoroughly reviews and analyzes the literature by developing a link between knowledge management and value creation. The studies were explored from selected databases including “Google scholar”, “Emerald” and “ProQuest” using the keyword search, namely, “Knowledge Sharing”, “Learning Orientation”, “Organizational Memory”, “Knowledge Re-use”, “Knowledge Management”, “Knowledge-based View”, “Competitive Advantage”, “Value Creation” and “Social Capital” to reduce the interpretation bias.

Findings
Knowledge management is an important predictor of value creation which can be strengthened by developing strong interpersonal relationships with all stakeholders. Organizations can create competitive advantage by managing social capital through knowledge management processes including learning orientation, knowledge sharing, organizational memory and knowledge reuse.

Research limitations/implications
The study is based on a theoretical model and an apparent limitation is the non-existence here of contributions and discussions that have been based on empirical data. Future study may use other moderating and mediating variables such as industry type, market orientation, human capital and organizational climate to know whether knowledge management directly affects the value creation or indirectly through these variables. The hypotheses emerged from the model can be operationalized by generating the items from the review of the literature.

Originality/value
The study contributes to the knowledge management literature by developing a theoretical model of knowledge management based on underlying dimensions of learning orientation, knowledge sharing, organizational memory and knowledge re-use.
An improved kinematic model for serial robot calibration based on local POE formula using position measurement
Authors: Liu Hua , Zhu Weidong , Dong Huiyue , Ke Yinglin 
Published: December 2018

Purpose
This paper aims to propose a calibration model for kinematic parameters identification of serial robot to improve its positioning accuracy, which only requires position measurement of the end-effector.

Design/methodology/approach
The proposed model is established based on local frame representation of the product of exponentials (local POE) formula, which integrates all kinematic errors into the twist coordinates errors; then they are identified with the tool frame’ position deviations simultaneously by an iterative least squares algorithm.

Findings
To verify the effectiveness of the proposed method, extensive simulations and calibration experiments have been conducted on a 4DOF SCARA robot and a 5DOF drilling machine, respectively. The results indicate that the proposed model outperforms the existing model in convergence, accuracy, robustness and efficiency; fewer measurements are needed to gain an acceptable identification result.

Practical implications
This calibration method has been applied to a variable-radius circumferential drilling machine. The machine’s positioning accuracy can be significantly improved from 11.153 initially to 0.301 mm, which is well in the tolerance (±0.5 mm) for fastener hole drilling in aircraft assembly.

Originality/value
An accurate and efficient kinematic calibration model has been proposed, which satisfies the completeness, continuity and minimality requirements. Due to generality, this model can be widely used for serial robot kinematic calibration with any combination of revolute and prismatic joints.
Seismic damage of gravity abutment in liquefied ground
Authors: Wang Haitao , Shen Jiayu , Gao Da 
Published: December 2018

Purpose
Abutment damage in liquefied ground is an important form of seismic damage of bridge structure. This paper aims to further research the effect of beam restriction on seismic damage mode of abutment in liquefied ground.

Design/methodology/approach
Based on the investigation of the seismic damage of Shengli Bridge in Tangshan earthquake, the finite element software dynamic effective stress analysis for ground (UWLC) is used to simulate the seismic damage of Shengli Bridge, and the results were compared with the actual seismic damage results. Then, the influences of the horizontal binding force of the beam, the liquefaction layer thickness, the top weight of the abutment, the peak acceleration, the liquefaction layer buried depth and the type of the foundation soil on the abutment seismic damage model are studied.

Findings
The results show that numerical simulation results are consistent with the actual seismic damage, and it is feasible to use UWLC software to simulate seismic damage. The results show that the seismic failure mode of the gravity abutment in liquefied ground is slip–rotation coupling type, not single slip type or rotation type. The large deformation of abutment bottom layer, horizontal binding force of the beam and post-stage soil pressure are the main reasons for abutment rotation or even destruction.

Research limitations/implications
A series of basic assumptions are used in the calculation process in this paper. The gravity abutment is defined as the elastic body and neglects its local deformation. The soil layer is a homogeneous isotropic. The consolidation process and the drainage boundary problem are not considered in the calculation process. Therefore, the paper may have some limitations.

Originality/value
To further research the seismic damage mode and influencing factors of abutment in liquefied ground, in this paper, based on the investigation of the seismic damage of Shengli Bridge in Tangshan earthquake, the finite element software UWLC is used to simulate the seismic damage of Shengli Bridge, and the results were compared with the actual seismic damage results. The seismic damage mode and influencing factors of gravity abutment in liquefied ground have been studied.
Re-imagining the country-of-origin effect: a promulgation approach
Authors: Andéhn Mikael , L’espoir Decosta Jean-Noel Patrick 
Published: December 2018

PurposeThe country-of-origin effect (COO) has, as a research domain, suffered from several theoretical and methodological problems and tendencies including an incomplete conceptualization of its constituent components. The purpose of this study is to first problematize the concept in extant literature and to consequently propose a reconceptualization of the concept.Design/methodology/approachAs part of lateral promulgation, the authors use theoretical and methodological ideas from other disciplines such as psychology, ethnography and geography to problematize the present conceptualization of COO in extant literature to reveal research possibilities relevant to, but underrepresented or absent in, COO research.FindingsThis study identifies several central theoretical and methodological problems and reveals that (1) COO is not necessarily linear and alternative modes of engagement with consumption need to be considered; (2) many of these problems can be addressed by alternative methodologies; and (3) COO operates at the level of symbolic orders that require a further engagement with the role of place in human experience.Research/limitations/implicationsThe findings suggest that in future research, field experiments be considered to resolve some of the methodological artefacts that have hampered past research; qualitative methods be applied to uncover unexpected uses of place association beyond being mere quality proxies; and alternative areas of relevance, such as macro-level trade and exports from emerging economies, be entertained.Originality ValueThe study’s approach to problematizing and refining extant knowledge enable it to promulgate new knowledge and research directions for a research area that has historically suffered from a tendency to be self-referential.
Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety
Authors: Taguchi Hitoshi , Oishi Keiko , Shingu Koh , Matsumoto Hideo , Masuzawa Munehiro 
Published: December 2018

AbstractBackgroundA preliminary study has shown effective cancer pain relief by intrathecal betamethasone (ITB). However, further evidence is needed to support this new approach.MethodsCancer patients with opioid‐resistant pain received lumbar intrathecal administration of betamethasone 2 or 3 mg once a week for 28 days. Immediate and short‐term analgesia (using a percentage pain reduction scale and a numerical rating scale, NRS) and long‐term analgesia (using NRS) were assessed. Patients were classified into two groups according to the most painful site of metastasis: vertebral column and/or surrounding nerve plexus metastases (group A) and other metastases distal from the vertebral column (group B).ResultsA total of 104 patients received ITB. Pain relief was observed not only in the lower half but also in the upper half of the body. The proportion of group A patients who experienced immediate analgesia was 81% (47/58), which was significantly greater than that of group B (P < 0.001). A decrease in NRS scores 1 day after ITB administration was observed in significantly more patients in group A than in group B (P < 0.001). Long‐term analgesia was also recorded in a greater proportion of patients in group A than in group B in the 7‐day (59%, 38/64 vs 6%, 2/33) and 28‐day periods (71%, 40/56 vs 31%, 8/26) (P < 0.001). No adverse effects related to neurotoxicity were recorded.ConclusionIntrathecal injection of betamethasone produced analgesia for opioid‐resistant cancer pain, and may be a potent therapeutic option for intolerable pain from vertebral column and/or surrounding nerve plexus metastases.
The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self‐administration and seeking
Authors: Morisot Nadege , Berger Anthony L. , Phamluong Khanhky , Cross Alan , Ron Dorit 
Published: December 2018

AbstractFyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol‐dependent molecular and behavioral effects. We show that systemic administration of AZD0530 prevents alcohol‐induced Fyn activation and GluN2B phosphorylation in the DMS of mice. We further report that a single dose of AZD0530 reduces alcohol operant self‐administration and promotes extinction of alcohol self‐administration without altering basal and dopamine D1 receptor‐dependent locomotion. Together, our findings suggest that AZD0530, through its inhibitory actions on Fyn kinase, dampens alcohol seeking and drinking.
Association between semen parameters and chance of fatherhood ‐ a long‐term follow‐up study
Authors: Malm G. , Rylander L. , Giwercman A. , Haugen T. B. 
Published: December 2018

AbstractBackgroundEvaluation of male fertility includes standard semen analysis; however, there is uncertainty about the value of sperm parameters in predicting fertility.ObjectiveTo evaluate the association between semen parameters and fatherhood during a long‐time period.Materials and methodsSemen parameters (total sperm count, concentration, motility, and morphology) and sperm DNA fragmentation Index (DFI) assessed on samples collected from 195 Norwegian men from the general population in 2001/2002 were matched with information about fatherhood until 2015, obtained from the Medical Birth Register. The parameters were dichotomized as normal vs. abnormal according to the WHO reference values from 1999 and 2010. Cut‐offs at 20% and 30% were used for DFI.ResultsAmong men who had no children before 2003, those with normal progressive sperm motility had more often become fathers (WHO 1999, cut‐off ≥50%, adjusted OR 2.8, 95% CI 1.3–6.1 and WHO 2010, cut‐off ≥32%; aOR 4.2, 95% CI 1.1–15). Based on the WHO 1999 reference value, men with normal sperm concentration (≥20 × 106/mL) had more often become fathers (aOR 3.1, 95% CI 1.1–8.6). Men with progressive sperm motility ≥50% and concentration ≥20 × 106/mL did more often achieve fatherhood (aOR 8.4, 95% CI 2.1–34). For DFI, there was a borderline significance at cut‐off 20% in the group of men who had ever been fathers (OR 2.7, 95% CI 1.0–7.0 p < 0.05).DiscussionThe results indicate that sperm progressive motility, sperm concentration, and DFI are associated with fatherhood during a longer time period, with sperm motility being most consistent. Although the sample size is relatively small and our results should be replicated in larger studies, they may be of clinical relevance.ConclusionSemen parameters may have a diagnostic value not only in a short time frame but also for predicting future fertility potential.
The sonic hedgehog pathway mediates Tongxinluo capsule‐induced protection against blood‐brain barrier disruption after ischaemic stroke in mice
Authors: Liu Shen , Chang Liping , Wei Cong 
Published: December 2018

AbstractTongxinluo capsule (TXL), a Chinese prescription, has been extensively used for treating ischaemic cerebrovascular diseases in China. Studies have demonstrated that TXL protects the blood‐brain barrier (BBB) after cerebral ischaemia. However, the underlying protective mechanisms are not fully elucidated. Enlightened by the critical role of sonic hedgehog (Shh) pathway in promoting BBB integrity through up‐regulating tight junction (TJ) proteins, we examined whether the Shh pathway could mediate TXL‐induced up‐regulation of TJ proteins and subsequent protection against BBB disruption after stroke. Ischaemic stroke was induced in adult male C57BL/6J mice by permanent middle cerebral artery occlusion (pMCAO). The mice were orally administered TXL (3.0 g/kg) at 1, 3 and 21 hours after stroke. Meanwhile, cyclopamine, a specific Shh pathway inhibitor, was intraperitoneally injected at 1 and 21 hours after stroke. The following parameters were measured at 6 and 24 hours after pMCAO: BBB permeability; TJ proteins including occludin, claudin‐5 and zonula occludens‐1 (ZO‐1); and Shh signalling molecules such as Shh, Patched, Smoothened (Smo) and Gli‐1. Our results showed that TXL protected against BBB disruption at 6 and 24 hours after pMCAO, and cyclopamine partly reversed the protective effect of TXL on BBB. Meanwhile, cyclopamine blocked the effect of TXL–up‐regulated expression of occludin, claudin‐5 and ZO‐1. Moreover, TXL up‐regulated the expression of Shh derived from astrocytes, Patched, Smo and Gli‐1, and thus activated the Shh pathway. And cyclopamine inhibited TXL‐induced activation of the Shh pathway. Thus, our study demonstrates that the Shh pathway mediates TXL‐induced protection against BBB disruption after ischaemic stroke.
Neoglacial transition of atmospheric circulation patterns over Fennoscandia recorded in Holocene Lake Torneträsk sediments
Authors: Thienemann Matthias , Kusch Stephanie , Vogel Hendrik , Ritter Benedikt , Schefuẞ Enno , Rethemeyer Janet 
Published: December 2018

Atmospheric circulation over the North Atlantic has undergone significant fluctuations during the Holocene. To better constrain these changes and their impacts on the Fennoscandian subarctic, we investigated molecular and inorganic proxies as well as plant wax D/H isotopes (δDC28) in a Holocene sedimentary record from Lake Torneträsk (Sweden). These data indicate a thermal maximum c. 8100 to 6300 cal. a BP with reduced soil organic matter input, followed by a long‐term cooling trend with increasing soil erosion. δD data suggest a stable atmospheric circulation with predominance of westerly flow and North Atlantic moisture sourcing during the Early and Middle Holocene. A substantial depletion in δD followed by increased flood frequency starting at c. 5300 cal. a BP and intensifying c. 1500 cal. a BP suggests a reorganization of the atmospheric circulation from zonal towards meridional flow with predominantly Arctic Ocean and Baltic Sea moisture sourcing.
Mitochondrial DNA mutation m.3243A>G is associated with altered mitochondrial function in peripheral blood mononuclear cells, with heteroplasmy levels and with clinical phenotypes
Authors: Geng X. , Zhang Y. , Yan J. , Chu C. , Gao F. , Jiang Z. , Zhang X. , Chen Y. , Wei X. , Feng Y. , Lu H. , Wang C. , Zeng F. , Jia W. 
Published: December 2018

AbstractAimsTo investigate the associations among heteroplasmy levels (i.e. the proportions of mutant and wild‐type mitochondrial DNA in the same cell), mitochondrial function and clinical severity of the m.3243A>G mutation.MethodsA total of 17 participants carrying the m.3243A>G mutation and 17 sex‐ and age‐matched healthy controls were included in this study. Heteroplasmy levels of the m.3243A>G mutation in leukocytes, saliva and urine sediment were determined by pyrosequencing. The clinical evaluation included endocrinological, audiological and ophthalmological examinations. Mitochondrial function was determined in peripheral blood mononuclear cells isolated from participants.ResultsHeteroplasmy levels in urine sediment were higher than those in leukocytes and saliva. Reduced levels of adenosine triphosphate and mitochondrial membrane potential, and increased reactive oxygen species production were observed in mutant peripheral blood mononuclear cells (all P < 0.05). Linear regression analysis indicated that higher heteroplasmy levels in peripheral blood leukocytes were associated with increased levels of glycated albumin and HbA1c, and decreased total hip bone mineral density T‐score after adjustment for age and sex (all P < 0.05). Furthermore, mitochondrial membrane potential was independently associated with bone mineral density T‐score at the femoral neck (P < 0.05).ConclusionsHeteroplasmy levels in peripheral blood leukocytes and mitochondrial membrane potential in peripheral blood mononuclear cells were closely associated with clinical manifestations and were valuable for evaluation of the clinical severity of the m.3243A>G mutation.
Dietary protein affects both the dose and pattern of insulin delivery required to achieve postprandial euglycaemia in Type 1 diabetes: a randomized trial
Authors: Evans M. , Smart C. E. M. , Paramalingam N. , Smith G. J. , Jones T. W. , King B. R. , Davis E. A. 
Published: December 2018

AbstractAimTo quantify the insulin requirement for a high‐protein meal compared with a low‐protein meal, controlling for carbohydrate and fat content.MethodsIn this crossover study, young people with Type 1 diabetes were randomized to consume a high‐ (60 g) or low‐protein meal (5 g), each containing 30 g carbohydrate and 8 g fat. A variation of the insulin clamp technique was used to determine the insulin requirements to maintain euglycaemia for the following 5 h.ResultsA total of 11 participants (mean ± sd age 16.5 ± 2.7 years, HbA1c 52 ± 8.7 mmol/mol [6.9 ± 0.8%], diabetes duration 6.9±5.1 years) completed the study. The mean insulin requirements for the high‐protein meal were higher than for the low‐protein meal [10.3 (CI 8.2, 12.57) vs 6.7 units (CI 4.7, 8.8); P=0.001], with inter‐individual requirements ranging from 0.9 to six times the low‐protein meal requirement. Approximately half the additional insulin [1.1 units/h (CI 0.5, 1.8; P=0.001)] was given in the first 2 h, compared with an additional 0.5 units/h (CI –0.2, 1.2; P=0.148) in the second 2 h and 0.1 units (CI –0.6, 0.8; P=0.769) in the final hour.ConclusionsA high‐protein meal requires ~50% more insulin to maintain euglycaemia than a low‐protein meal that contains the same quantity of carbohydrate. The majority is required within the first 2 h. Inter‐individual differences exist in insulin requirements for dietary protein.
Diagnostic exome sequencing in 100 consecutive patients with both epilepsy and intellectual disability
Authors: Snoeijen‐Schouwenaars Francesca M. , van Ool Jans S. , Verhoeven Judith S. , van Mierlo Petra , Braakman Hilde M. H. , Smeets Eric E. , Nicolai Joost , Schoots Jeroen , Teunissen Mariel W. A. , Rouhl Rob P. W. , Tan In Y. , Yntema Helger G. , Brunner Han G. , Pfundt Rolph , Stegmann Alexander P. , Kamsteeg Erik‐Jan , Schelhaas Helenius J. , Willemsen Marjolein H. 
Published: December 2018

SummaryObjectiveEpilepsy is highly prevalent among patients with intellectual disability (ID), and seizure control is often difficult. Identification of the underlying etiology in this patient group is important for daily clinical care. We assessed the diagnostic yield of whole exome sequencing (WES). In addition, we evaluated which clinical characteristics influence the likelihood of identifying a genetic cause and we assessed the potential impact of the genetic diagnosis on (antiepileptic) treatment strategy.MethodsOne hundred patients with both unexplained epilepsy and (borderline) ID (intelligence quotient ≤ 85) were included. All patients were evaluated by a clinical geneticist, a (pediatric) neurologist, and/or a specialist ID physician. WES analysis was performed in two steps. In step 1, analysis was restricted to the latest versions of ID and/or epilepsy gene panels. In step 2, exome analysis was extended to all genes (so‐called full exome analysis). The results were classified according to the American College of Medical Genetics and Genomics guidelines.ResultsIn 58 patients, the diagnostic WES analysis reported one or more variant(s). In 25 of the 100 patients, these were classified as (likely) pathogenic, in 24 patients as variants of uncertain significance, and in the remaining patients the variant was most likely not related to the phenotype. In 10 of 25 patients (40%) with a (likely) pathogenic variant, the genetic diagnosis might have an impact on the treatment strategy in the future.SignificanceThis study illustrates the clinical diagnostic relevance of WES for patients with both epilepsy and ID. It also demonstrates that implementing WES diagnostics might have impact on the (antiepileptic) treatment strategy in this population. Confirmation of variants of uncertain significance in (candidate) genes may further increase the yield.
Cis‐trans proline isomers in the catalytic domain of calcineurin
Authors: Teixeira João M.C. , Guasch Alicia , Biçer Atilla , Aranguren‐Ibáñez Álvaro , Chashmniam Saeed , Paniagua Juan Carlos , Pérez‐Riba Mercè , Fita Ignacio , Pons Miquel 
Published: December 2018

Calcineurin is an essential calcium‐activated serine/threonine phosphatase. The six NMR‐observable methionine methyl groups in the catalytic domain of human calcineurin Aα (CNA) were assigned and used as reporters of the presence of potential cis‐trans isomers in solution. Proline 84 is found in the cis conformation in most calcineurin X‐ray structures, and proline 309, which is part of a highly conserved motif in phosphoprotein phosphatases, was modeled with a cis peptide bond in one of the two molecules present in the asymmetric unit of CNA. We mutated each of the two prolines to alanine to force the trans conformation. Solution NMR shows that the P84A CNA mutant exists in two forms, compatible with cis‐trans isomers, while the P309A mutant is predominantly in the trans conformation.DatabasePDB depositions mentioned PDB 5C1V and 2JOG.