bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women with a low-satiety phenotype show impaired appetite control and greater resistance to weight loss
Authors: Buckland Nicola J. , Camidge Diana , Croden Fiona , Myers Anna , Lavin Jacquelynne H. , Stubbs R. James , Blundell John E. , Finlayson Graham 
Published: July 2019

AbstractThis trial compared weight loss outcomes over 14 weeks in women showing low- or high-satiety responsiveness (low- or high-satiety phenotype (LSP, HSP)) measured by a standardised protocol. Food preferences and energy intake (EI) after low and high energy-density (LED, HED) meals were also assessed. Ninety-six women (n 52 analysed; 41·24 (SD 12·54) years; 34·02 (sd 3·58) kg/m2) engaged in one of two weight loss programmes underwent LED and HED laboratory test days during weeks 3 and 12. Preferences for LED and HED food (Leeds Food Preference Questionnaire) and ad libitum evening meal and snack EI were assessed in response to equienergetic LED and HED breakfasts and lunches. Weekly questionnaires assessed control over eating and ease of adherence to the programme. Satiety quotients based on subjective fullness ratings post LED and HED breakfasts determined LSP (n 26) and HSP (n 26) by tertile splits. Results showed that the LSP lost less weight and had smaller reductions in waist circumference compared with HSP. The LSP showed greater preferences for HED foods, and under HED conditions, consumed more snacks (kJ) compared with HSP. Snack EI did not differ under LED conditions. LSP reported less control over eating and reported more difficulty with programme adherence. In conclusion, low-satiety responsiveness is detrimental for weight loss. LED meals can improve self-regulation of EI in the LSP, which may be beneficial for longer-term weight control.
Chocolate consumption and risk of gestational diabetes mellitus: the Japan Environment and Children’s Study
Authors: Dong Jia-Yi , Kimura Takashi , Ikehara Satoyo , Cui Meishan , Kawanishi Yoko , Yamagishi Kazumasa , Ueda Kimiko , Iso Hiroyasu ,   the Japan Environment and Children’s Study Group
Published: July 2019

AbstractThe association of chocolate consumption with risk of gestational diabetes has not been examined. We aimed to investigate the prospective association between chocolate consumption and risk of gestational diabetes in a large birth cohort in Japan. A total of 97 454 pregnant women with a median gestational age of 12 weeks were recruited from January 2011 to March 2014. Data on demographic information, disease history, socio-economic status, lifestyle and dietary habits were obtained at the study enrolment. Dietary intake during the past 12 months before study enrolment was assessed through a semi-quantitative FFQ. The logistic regression was used to obtain the OR of gestational diabetes in relation to chocolate consumption. Among 84 948 women eligible for the analysis, 1904 cases of gestational diabetes (2·2 %) were identified during the period of pregnancy. After controlling for potential confounding factors including age, smoking status, drinking status, education level, occupation, pre-pregnant BMI, depression, previous history of macrosomia babies, parity, physical activity and dietary factors, women in the highest quartile of chocolate consumption, compared with those in the lowest quartile, had a significantly lower risk of developing gestational diabetes (OR 0·78, 95 % CI 0·67, 0·90; P for trend = 0·002). Stratified analyses suggested that the association was not significantly modified by pre-pregnancy BMI, age, parity, smoking status or drinking status. The present prospective cohort study provided evidence that chocolate consumption was associated with a significant lower risk of gestational diabetes in Japanese women.
Protein supplementation combined with low-intensity resistance training in geriatric medical patients during and after hospitalisation: a randomised, double-blind, multicentre trial
Authors: Gade Josephine , Beck Anne Marie , Andersen Hanne E. , Christensen Britt , Rønholt Finn , Klausen Tobias W. , Vinther Anders , Astrup Arne 
Published: July 2019

AbstractSarcopenia (loss of muscle mass/strength) burdens many older adults – hospitalised older adults being particularly vulnerable. Treating the condition, protein supplementation (PrS) and resistance training (RT) may act synergistically. Therefore, this block-randomised, double-blind, multicentre intervention study, recruiting geriatric patients > 70 years from three medical departments, investigated the effect of PrS combined with RT during hospitalisation and 12 weeks after discharge. Participants were randomly allocated (1:1) to receive PrS (totally 27·5 g whey protein/d, about 2000 kJ/d) or isoenergetic placebo-products (< 1·5 g protein/d) divided into two servings per d to supplement the habitual diet. Both groups were engaged in a standardised, progressive low-intensity RT programme for the lower extremities (hospital: supervised daily/after discharge: self-training 4×/week). From April 2016 to September 2017, 2351 patients were screened, 462 were eligible, and 165 included. Fourteen were excluded and ten dropped out, leaving 141 participants in the intention-to-treat analysis. The average total protein intake during hospitalisation/after discharge was 1·0 (interquartile range (IQR) 0·8, 1·3)/1·1 (IQR 0·9, 1·3) g/kg per d (protein-group) and 0·6 (IQR 0·5, 0·8)/0·9 (IQR 0·6, 1·0) g/kg per d (placebo group). Both groups improved significantly for the primary and secondary endpoints of muscle mass/strength, functional measurements and quality of life, but no additional effect of PrS was seen for the primary endpoint (30-s chair stand test, repetitions, median changes from baseline: (standard test: 0 (IQR 0, 5) (protein group) v. 2 (IQR 0, 6) (placebo group) and modified test: 2 (IQR 0, 5) (protein group) v. 2 (IQR −1, 5) (placebo group)) or any secondary endpoints (Mann–Whitney U tests, P > 0·05). In conclusion, PrS increasing the total protein intake by 0·4 and 0·2 g/kg per d during hospitalisation and after discharge, respectively, does not seem to increase the adaptive response to low-intensity RT in geriatric medical patients.
A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis
Authors: Morchón R. , Carretón E. , García R. , Zueva T. , Kartashev V. , Simón F. 
Published: July 2019

Abstract
Human subcutaneous dirofilariosis has several clinical presentations. Many cases present as subcutaneous nodules, as a consequence of a local inflammatory reaction that encapsulates and destroys the worms. In addition, there are cases in which migrating worms located in the ocular area remain unencapsulated. In the present work, the levels of two pro-inflammatory eicosanoids, thromboxane B2 (TxB2) and leukotriene B4 (LTB4) are analysed by commercial Enzime-Linked immunosorbent assay (ELISA) in serum samples from 43 individuals, 28 diagnosed as having subcutaneous dirofilariasis presenting a subcutaneous nodule, five diagnosed as having dirofilariasis, in which the worms remained unencapsulated in the periphery of the eye, and ten healthy individuals living in a non-endemic area, used as controls. The worms were surgically removed, identifying Dirofilaria repens as the causative agent in all cases, by Polymerase Chain Reaction (PCR). Individuals with nodules showed significantly higher levels of TxB2 and LTB4 than healthy controls, whereas significant differences in LTB4 levels were observed between individuals with unencapsulated worms and healthy controls. It is speculated that the absence of LTB4 may contribute to the fact that worms remain unencapsulated as a part of immune evasion mechanisms.
Genotypes of Echinococcus isolated from domestic livestock in Kazakhstan
Authors: Abdybekova A.M. , Zhang Z. , Sultanov A.A. , Abdibayeva A.A. , Zhaksylykova A.A. , Junisbayeva S.M. , Aubakirov M.Zh. , Akhmetova G.D. , Torgerson P.R. 
Published: July 2019

Abstract
The diversity and importance of Echinococcus species in domesticated animals in Kazakhstan are poorly understood. In this study, 17 cysts of Echinococcus were collected from cattle and a further 17 cysts from sheep. DNA was extracted from the individual cysts and used for polymerase chain reaction amplification of mitochondrial subunit 1 of the cox1 and nadh1 gene. Amplicon sequencing results revealed the presence of Echinococcus granulosus sensu stricto G1 in 15 cattle and 15 sheep, and G3 genotype from two cattle. Echinococcus canadensis (G6/G7 strain) was found in two cysts originating from sheep.
The Army and the Spread of Roman Citizenship
Authors: Lavan Myles 
Published: July 2019

AbstractThis paper draws on recent advances in our knowledge (much of it owed to the proliferation of military diplomas) and a new analytical method to quantify the number of soldiers and their children who received Roman citizenship between 14 and 212c.e.Although significant uncertainties remain, these can be quantified and turn out to be small relative to the overall scale of enfranchisement. The paper begins by reviewing what is known about grants of citizenship to soldiers, with particular attention to the remaining uncertainties, before presenting a quantitative model of the phenomenon. The total number of beneficiaries was somewhere in the region 0.9–1.6 million — significantly lower than previous estimates have suggested. It also emerges that the rate of enfranchisement varied substantially over time, in line with significant changes in manpower, length of service (and hence the number of recruits and discharged veterans) and the rate of family formation among soldiers. The Supplementary Material available online (https://doi.org/10.1017/S0075435819000662) contains a database of military diplomas (Supplementary Appendix 1), a mathematical model of enfranchisement implemented in MS Excel (Supplementary Appendix 2), a description of the model (Supplementary Appendix 3A) and a derivation of the model of attrition across service cohorts in Fig. 6 (Supplementary Appendix 3B).
Comparative Simulation Study for Configuring Turning Point in Multiple Robot Path Planning: Robust Data Envelopment Analysis
Authors: Fazlollahtabar Hamed 
Published: July 2019

SUMMARYThis paper concerns with comparing simulation studies for a newly developed concept of turning point to be used in multiple robot path planning. Different critical factors and design parameters are collected and statistical analyses are performed. After configuring different simulation scenarios, the efficient one is evaluated using a robust data envelopment analysis (RDEA). Due to uncertain aspects of various simulations scenarios, robust version of data envelopment analysis is proposed. Here, major criteria in robot path planning are deadlock and conflict avoidance, throughput, mean flow time, and effective total distance travelled. To determine the effective experiment for the proposed simulation model, RDEA is used. A comparative study with respect to different experiments having various simulation setting is developed. The results for a real robotic manufacturing cell system show effectiveness of the proposed process. Also, the efficient simulation software is determined by multiaspect analysis.
Cost-Effectiveness of the Transmural Trauma Care Model (TTCM) for the Rehabilitation of Trauma Patients
Authors: Wiertsema Suzanne H , van Dongen Johanna M , Geleijn Edwin , Huijsmans Rosalie J , Bloemers Frank W , de Groot Vincent , Ostelo Raymond WJG 
Published: July 2019

AbstractObjectivesTo assess the societal cost-effectiveness of the Transmural Trauma Care Model (TTCM), a multidisciplinary transmural rehabilitation model for trauma patients, compared with regular care.MethodsThe economic evaluation was performed alongside a before-and-after study, with a convenience control group measured only afterward, and a 9-month follow-up. Control group patients received regular care and were measured before implementation of the TTCM. Intervention group patients received the TTCM and were measured after its implementation. The primary outcome was generic health-related quality of life (HR-QOL). Secondary outcomes included disease-specific HR-QOL, pain, functional status, and perceived recovery.ResultsEighty-three trauma patients were included in the intervention group and fifty-seven in the control group. Total societal costs were lower in the intervention group than in the control group, but not statistically significantly so (EUR-267; 95 percent confidence interval [CI], EUR-4,175–3011). At 9 months, there was no statistically significant between-group differences in generic HR-QOL (0.05;95 percent CI, −0.02–0.12) and perceived recovery (0.09;95 percent CI, −0.09–0.28). However, mean between-group differences were statistically significantly in favor of the intervention group for disease-specific HR-QOL (−8.2;95 percent CI, −15.0–−1.4), pain (−0.84;95CI, −1.42–−0.26), and functional status (−20.1;95 percent CI, −29.6–−10.7). Cost-effectiveness acceptability curves indicated that if decision makers are not willing to pay anything per unit of effect gained, the TTCM has a 0.54–0.58 probability of being cost-effective compared with regular care. For all outcomes, this probability increased with increasing values of willingness-to-pay.ConclusionsThe TTCM may be cost-effective compared with regular care, depending on the decision-makers willingness to pay and the probability of cost-effectiveness that they perceive as acceptable.
A Non-inferiority Framework for Cost-Effectiveness Analysis
Authors: Xie Xuanqian , Falk Lindsey , Brophy James M. , Tu Hong Anh , Guo Jennifer , Gajic-Veljanoski Olga , Sikich Nancy , Dhalla Irfan A. , Ng Vivian 
Published: July 2019

AbstractBackgroundTraditional decision rules have limitations when a new technology is less effective and less costly than a comparator. We propose a new probabilistic decision framework to examine non-inferiority in effectiveness and net monetary benefit (NMB) simultaneously. We illustrate this framework using the example of repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT) for treatment-resistant depression.MethodsWe modeled the quality-adjusted life-years (QALYs) associated with the new intervention (rTMS), an active control (ECT), and a placebo control, and we estimated the fraction of effectiveness preserved by the new intervention through probabilistic sensitivity analysis (PSA). We then assessed the probability of cost-effectiveness using a traditional cost-effectiveness acceptability curve (CEAC) and our new decision-making framework. In our new framework, we considered the new intervention cost-effective in each simulation of the PSA if it preserved at least 75 percent of the effectiveness of the active control (thus demonstrating non-inferiority) and had a positive NMB at a given willingness-to-pay threshold (WTP).ResultsrTMS was less effective (i.e., associated with fewer QALYs) and less costly than ECT. The traditional CEAC approach showed that the probabilities of rTMS being cost-effective were 100 percent, 39 percent, and 14 percent at WTPs of $0, $50,000, and $100,000 per QALY gained, respectively. In the new decision framework, the probabilities of rTMS being cost-effective were reduced to 23 percent, 21 percent, and 13 percent at WTPs of $0, $50,000, and $100,000 per QALY, respectively.ConclusionsThis new framework provides a different perspective for decision making with considerations of both non-inferiority and WTP thresholds.
Brazil’s new president and ‘ruralists’ threaten Amazonia’s environment, traditional peoples and the global climate
Authors: Ferrante Lucas , Fearnside Philip M 
Published: July 2019

SummaryJair Bolsonaro (Brazil’s new president) and “ruralists” (large landholders and their representatives) have initiated a series of measures that threaten Amazonia’s environment and traditional peoples, as well as global climate. These include weakening the country’s environmental agencies and forest code, granting amnesty to deforestation, approving harmful agrochemicals, reducing protected areas, and denying the existence of anthropogenic climate change. Both the measures themselves and the expectation of impunity they encourage have spurred increased deforestation, which contributes to climate change and to land conflicts with traditional peoples. Countries and companies that import Brazilian beef, soy and minerals are stimulating these impacts.
Timescales of Birkeland Currents Driven by the IMF
Authors: Coxon John C. , Shore Robert M. , Freeman Mervyn P. , Fear Robert C. , Browett Stephen D. , Smith Andrew W. , Whiter Daniel K. , Anderson Brian J. 
Published: July 2019

AbstractWe obtain current densities from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE), alongside By and Bz from the Interplanetary Magnetic Field (IMF) for March 2010. For each AMPERE spatial coordinate, we cross‐correlate current density with By and Bz, finding the maximum correlation for lags up to 360 min. The patterns of maximum correlation contain large‐scale structures consistent with the literature. For the correlation with By, the lags on the dayside are 10 min at high latitudes but up to 240 min at lower latitudes. Lags on the nightside are 90–150 min. For Bz, the shortest lags on the dayside are 10–20 min; on the equatorward edge of the current oval, 60–90 min; and on the nightside, predominantly 90–150 min. This novel approach enables us to see statistically the timescales on which information is electrodynamically communicated to the ionosphere after magnetic field lines reconnect on the dayside and nightside.
Summer Carbonate Chemistry in the Dalton Polynya, East Antarctica
Authors: Arroyo M. C. , Shadwick E. H. , Tilbrook B. 
Published: July 2019

AbstractThe carbonate chemistry in the Dalton Polynya in East Antarctica (115°–123°E) was investigated in summer 2014/2015 using high‐frequency underway measurements of CO2 fugacity (fCO2) and discrete water column measurements of total dissolved inorganic carbon (TCO2) and total alkalinity. Air‐sea CO2 fluxes indicate this region was a weak net source of CO2 to the atmosphere (0.7 ± 0.9 mmol C m−2 day−1) during the period of observation, with the largest degree of surface water supersaturation (ΔfCO2 = +45 μatm) in ice‐covered waters near the Totten Ice Shelf (TIS) as compared to the ice‐free surface waters in the Dalton Polynya. The seasonal depletion of mixed‐layer TCO2 (6 to 51 μmol/kg) in ice‐free regions was primarily driven by sea ice melt and biological CO2 uptake. Estimates of net community production (NCP) reveal net autotrophy in the ice‐free Dalton Polynya (NCP = 5–20 mmol C m−2 day−1) and weakly heterotrophic waters near the ice‐covered TIS (NCP = −4–0 mmol C m−2 day−1). Satellite‐derived estimates of chlorophyll a (Chl a) and sea ice coverage suggest that the early summer season in 2014/2015 was anomalous relative to the long‐term (1997–2017) record, with lower surface Chl a concentrations and a greater degree of sea ice cover during the period of observation; the implications for seasonal primary production and air‐sea CO2 exchange are discussed. This study highlights the importance of both physical and biological processes in controlling air‐sea CO2 fluxes and the significant interannual variability of the CO2 system in Antarctic coastal regions.
Less Remineralized Carbon in the Intermediate‐Depth South Atlantic During Heinrich Stadial 1
Authors: Lacerra Matthew , Lund David C. , Gebbie Geoffrey , Oppo Delia W. , Yu Jimin , Schmittner Andreas , Umling Natalie E. 
Published: July 2019

AbstractThe last deglaciation (~20–10 kyr BP) was characterized by a major shift in Earth's climate state, when the global mean surface temperature rose ~4 °C and the concentration of atmospheric CO2 increased ~80 ppmv. Model simulations suggest that the initial 30 ppmv rise in atmospheric CO2 may have been driven by reduced efficiency of the biological pump or enhanced upwelling of carbon‐rich waters from the abyssal ocean. Here we evaluate these hypotheses using benthic foraminiferal B/Ca (a proxy for deep water [CO32−]) from a core collected at 1,100‐m water depth in the Southwest Atlantic. Our results imply that [CO32−] increased by 22 ± 2 μmol/kg early in Heinrich Stadial 1, or a decrease in ΣCO2 of approximately 40 μmol/kg, assuming there were no significant changes in alkalinity. Our data imply that remineralized phosphate declined by approximately 0.3 μmol/kg during Heinrich Stadial 1, equivalent to 40% of the modern remineralized signal at this location. Because tracer inversion results indicate remineralized phosphate at the core site reflects the integrated effect of export production in the sub‐Antarctic, our results imply that biological productivity in the Atlantic sector of the Southern Ocean was reduced early in the deglaciation, contributing to the initial rise in atmospheric CO2.
Detection of Strong Precession Cycles from the Late Pliocene Sedimentary Records of Northeastern Tibetan Plateau
Authors: Su Qingda , Nie Junsheng , Luo Zeng , Li Mingsong , Heermance Richard , Garzione Carmala 
Published: July 2019

AbstractRecent studies demonstrate that aridification is sensitive to eccentricity forcing based on the northeastern Tibetan Plateau Cenozoic fluvio‐lacustrine stratigraphic records. However, it is unknown whether this is a bias associated with the fact that higher frequency periods normally have larger age model uncertainties, which tend to decrease spectral power of higher frequency orbital cycles (precession and obliquity) and enlarge lower frequency ones (eccentricity). Here we detect strong and well‐resolved (~23 and ~19 kyr) precession cycles in the magnetic susceptibility record of late Pliocene fluvio‐lacustrine sediments from the Qaidam Basin, northwestern China. We interpret the magnetic susceptibility as a proxy for the degree of chemical weathering in this region, based on the positive correlation between low‐frequency magnetic susceptibility and frequency‐dependent magnetic susceptibility. The different responses of magnetic susceptibility and a halite content proxy to orbital forcing suggest that aridification is more sensitive to eccentricity forcing than precipitation, but precipitation is more sensitive to precession forcing. This study indicates that different climatic aspects have different sensitivity to orbital forcing. Furthermore, a comparison of the magnetic susceptibility variations in the western Qaidam Basin and global ice volume proxy records suggests ice volume control of Qaidam Basin precipitation and chemical weathering at million‐year timescales.
Effects of Swell Waves on Atmospheric Boundary Layer Turbulence: A Low Wind Field Study
Authors: Zou Zhongshui , Song Jinbao , Li Peiliang , Huang Jian , Zhang Jun A. , Wan Zhanhong , Li Shuiqing 
Published: July 2019

AbstractThe effect of swell waves on atmospheric boundary layer turbulence under low winds was explored using data from a fixed platform located in the South China Sea. The wind spectra, cospectra, and Ogive curve measured at a height of 8 m above the mean sea surface provided direct evidence that wind stress was affected by swell waves. To interpret such phenomena, an improved approach was derived based on the fact that the total wind stress was the vector sum of turbulent stress and wave‐coherent stress. Different from the approaches of earlier studies, our approach did not align the turbulent stress with the mean wind speed. The influence of swell waves on the magnitude and direction of the total wind stress was analyzed using our approach. The results showed that the wave‐coherent stress derived from our data accounted for 32% of the total wind stress. The magnitude and angle of the wind stress changed by swell waves depended on the relative angle between the turbulent stress and swell direction.