bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nrf2/HO-1 Mediated Antioxidant Activities, Cytotoxicity Analysis and LCESI/ MS Profiling of Eulophia nuda L.
Authors: Nanekar Vikas , Shriram Varsha , Khare Tushar , Kumar Vinay 
Published: February 2019

Background:
Eulophia nuda, is a highly medicinal orchid with strong antioxidant and
anticancer potentials in traditional systems of medicine. But few reports are available on the scientific
validation. The aim of the study was to investigate phytochemical constituents, antioxidant and
cytotoxic efficacies of extracts of Eulophia nuda, and the underlying mechanisms-of-action via upregulation
of nuclear transcription factor-erythroid-2 related factor (Nrf2) and hemeoxygenase-1
(HO-1) pathways.

Methods:
Petroleum Ether (PEE), Ethyl Acetate (EAE), Methanol (ME) and Aqueous Methanol
(AqME) extracts of shade dried tubers were obtained and concentrated in vacuo. Total phenols, flavonoids,
condensed tannins, ascorbic acid and carotenoids were estimated from the extracts using
standard methods. Antioxidant activities of extracts were determined by total antioxidant, FRAP,
ABTS, DPPH, OH, H2O2, NO, O2
·- radical scavenging assays. Cytotoxicity of EAE and ME were
assessed against MCF7 cells in vitro. LC-ESI/MS profiling of EAE was carried out. Quantitative
Real-Time (qRT) PCR was used for the expression analysis of Nrf2 and HO1 genes in EAE-treated
MCF7 cells.

Results:
In vitro models confirmed strong dose-dependent antioxidant and free-radical scavenging
potencies of E. nuda tuber extracts. Overall antioxidant efficacies were in the order EAE > ME >
AqME > PEE. EAE showed striking cytotoxicity followed by ME (0.86% and 5.17% cell survival
at 1000 µg ml-1, respectively). LC-ESI/MS profiling of most potent extract EAE revealed 37 identified
compounds including catechin, taxifolin, tocopherol, trigallic acid and chlorogenic acid, all
known for their strong antioxidant/anticancer properties. Expression levels of Nrf2 and HO1 genes
were up-regulated in MCF7 cells beyond 50 μg ml-1 extract concentration with > 2-fold increase at
200 µg ml-1 EAE.

Conclusion:
The data demonstrated that E. nuda extracts possess strong free radical scavenging and
antioxidant efficacies and the mechanism of action may be via inducing Nrf2 and HO-1.
Effect of Polypropylene Imine Nanocomposite on Gram-Positive and Gram-Negative Bacteria
Authors: Mohammadpour Bashir , Boshagh Mohammad A. , Hayati Bagher , Farhadi Leila , Kashefi Hajar , Salimizand Himen 
Published: February 2019

Background:
Nosocomial infection is a serious threat to hospitalized patients in healthcare
when last-resort antibiotics do not act against pathogenic bacteria.

Aims:
The aim of this study was to study the effect of Polypropylene imine nanocomposite (PPI/CNT) on
Gram-Positive and Gram-Negative bacteria.

Methods:
PPI/CNT component was produced. Surface morphology and structure of PPI/CNT were analyzed
by Fourier-transform infrared (FTIR), Scanning Electron Microscopy (SAM) and Transmission
Electron Microscopy (TEM). Minimum Inhibitory Concentration (MIC) of PPI/CNT was determined
against various bacteria.

Results:
FTIR showed strong and wider peak binding molecules in the CNT/COOH and PPI/CNT component.
PPI/CNT component was denser in comparison to low carbon nanotube according to SAM test. TEM
images showed that carbon nanotube was covered by PPI dots. The lowest MIC concerns polymer particles
for Staphylococcus epidermidis were 0.0025 μM/ml and Mycobacterium smegmatis 0.005 μM/ml.

Conclusion:
Our result indicated that PPI/CNT nanocomposite had good activity against Gram-positive
and Gram-negative bacteria. Some of the gram-negative bacteria were tolerant up to highest concentration.
With more investigations, it can be used as a new antibacterial component.
Synergistic Extraction of Gold by Di-(2-ethylhexyl)phosphoric Acid - Isodecanol
Authors: Jalil Mohd Jumain , Afwanisa Nurul , Suhada Intan , Rani Noor Hidayu Abdul 
Published: February 2019

Objective and Background:
Synergistic extraction was introduced to replace single
extraction due to enhanced extraction efficiency of heavy metal.

Methodology:
In order to improve extraction efficiency, di-(2-ethylhexyl) phosphoric acid
(D2EHPA) was mixed with isodecanol to provide a synergistic effect together with leaching
solution which is thiourea. From the single extraction system, the optimum temperature is
found at 30°C producing the highest yield of %E of 91.30%. The single extraction also happened
better with the presence of Fe(III) solution and thiourea as the %E is at 91.23%.

Results and Conclusion:
It was found that the synergistic D2EHPA-isodecanol extraction is
successful as it yields higher %E than the single D2EHPA extraction.
Usefulness and Usability of a Personal Health Record and Survivorship Care Plan for Colorectal Cancer Survivors: Survey Study
Authors: Tarver Will L , Robb Bruce W , Haggstrom David A 
Published: February 2019

Background
As a result of improvements in cancer screening, treatment, and supportive care, nearly two-thirds of individuals diagnosed with colorectal cancer (CRC) live for 5 years after diagnosis. An ever-increasing population of CRC survivors creates a need for effective survivorship care to help manage and mitigate the impact of CRC and its treatment. Personal health records (PHRs) and survivorship care plans provide a means of supporting the long-term care of cancer survivors.

Objective
The purpose of this study is to characterize the usefulness of a CRC PHR and survivorship care plan and to describe the usability of these technologies in a population of CRC survivors. To our knowledge, this is the first study to assess a PHR and survivorship care plan specifically targeting CRC survivors.

Methods
Twenty-two patients with CRC were recruited from surgery clinics of an academic medical center and Veterans Affairs hospital in Indianapolis and provided access to an online Colorectal Cancer Survivor’s Personal Health Record (CRCS-PHR). Survey data were collected to characterize the usefulness of the CRCS-PHR and describe its usability in a population of CRC survivors. CRC survivors were surveyed 6 months after being provided online access. Means and proportions were used to describe the usefulness and ease of using the CRC website. Open-ended questions were qualitatively coded using the constant comparative method.

Results
CRC survivors perceived features related to their health care (ie, summary of cancer treatment history, follow-up care schedule, description of side effects, and list of community resources) to be more useful than communication features (ie, creating online relationships with family members or caregivers, communicating with doctor, and secure messages). CRC survivors typically described utilizing traditional channels (eg, via telephone or in person) to communicate with their health care provider. Participants had overall positive perceptions with respect to ease of use and overall satisfaction. Major challenges experienced by participants included barriers to system log-in, lack of computer literacy or experience, and difficulty entering their patient information.

Conclusions
For CRC, survivors may find the greater value in a PHR’s medical content than the communication functions, which they have available elsewhere. These findings regarding the usefulness and usability of a PHR for the management of CRC survivorship provide valuable insights into how best to tailor these technologies to patients’ needs. These findings can inform future design and development of PHRs for purposes of both cancer and chronic disease management.
Optimization of Water Fraction Gel Formula of Binahong Leaf (Anredera cordifolia (Ten.) Steen) With Gelling Agent of Sodium Alginate and Carboxymethyl Chitosan Combination
Authors: Edityaningrum Citra Ariani , Kintoko Kintoko , Zulien Feby , Widiyastuti Lina 
Published: February 2019

Water fraction of binahong (Anredera cordifolia (Ten.) Steen) leaf has been proven to heal ulcus diabetic. In order to make the use easier and more practical, in this study the water fraction of binahong leaves is formulated in gel preparation form. This study was conducted to obtain a comparison of the amount of sodium alginate and carboxymethyl chitosan as gelling agent to produce gel that meets the good physical requirements. The method used to determine the amount of comparison of sodium alginate and carboxymethyl chitosan is to use Simplex Lattice Design (SLD). Eight variations of gel formula are designed with the ratio of sodium alginate: carboxymethyl chitosan as follows: F1 (0:3% w/w), F2 (0:3% w/w), F3 (0.75:2.25% w/w), F4 (1.5:1.5 % w/w), F5 (1.5:1.5% w/w), F6 (2.25:0.75% w/w), F7 (3:0% w/w), F8 (3:0% w/w). Physical parameters observed included pH, viscosity, dispersion, and adherence. Data obtained compared with the actual conducted by researchers using one sample test t-test with 95% confidence level. Based on the results of the study, increased sodium alginate concentration can increase viscosity and adhesiveness and decrease the pH and spreadability of the gel. One sample t-test analysis shows that there is no significant difference between predicted parameter value and actual result so SLD equation can be used to construct gel formula of water fraction of binahong leaf. The conclusion is a combination of sodium alginate 1.546% w/w and carboxymethyl chitosan 1.454% w/w yield gel optimum. Physical parameter response of optimum formula is pH 5.86; viscosity 2000 cps; spreadability of 21,96 cm2; and adhesiveness of 19,81 seconds.
ELABORAÇÃO DE PÓRTICO DE CONCRETO ARMADO AO CONCURSO APARATO DE PROTEÇÃO AO OVO
Authors: Trevisol Loss Gabriela , Valduga Marina , Diehl Roberta , Poleto Zanon Willian 
Published: February 2019

O presente artigo relata a construção de um pórtico espacial de concreto armado, com dimensões definidas e volume limitado, cujo nome é Aparato de Proteção ao Ovo (APO), sendo parametrizado segundo as normas e técnicas estabelecidas pelo concurso de mesmo nome, promovido pelo Instituto Brasileiro
do Concreto (IBRACON). O pórtico foi desenvolvido com o intuito de suportar o maior número de cargas possíveis, além de apresentar uma baixa deformação. Para sua confecção foi utilizado o cimento CP V ARI, sílica ativa, areia fina, aditivo superplastificante e microfibra de polipropileno. Além da confecção do pórtico, foram moldados dois corpos de prova, para posteriormente conhecer suas resistências através do ensaio de compressão. A estrutura construída passou pelo ensaio de carregamento dinâmico com cargas crescentes de impacto, até a sua ruptura, resistindo a golpes de até 2,0 metros de altura, com uma carga de 15kg. Os dois corpos de prova realizados e rompidos no mesmo dia do APO obtiveram as resistências de 49,28 MPa e 75,61 MPa.
PENGEMBANGAN BISKUIT MPASI BERBAHAN DASAR BERBAGAI MACAM TEPUNG SEBAGAI PRODUK INOVASI MPASI
Authors: Marlina Paramitha Wirdani Ningsih , Maulianti Raden Roro Dwi Agustine , Fernandez Maria Meylan Yuliany 
Published: February 2019

Latar Belakang. Masa balita merupakan periode emas pertumbuhan dan perkembangan manusia. Kebanyakan masalah gizi yang terjadi saat ini akibat tidak seimbangnya asupan makanan yang dikonsumsi oleh balita baik secara makro maupun mikro. Perlu dikembangkan biskuit Makanan Pendamping Air Susu Ibu (MPASI) berbahan pangan lokal yang dapat memenuhi kebutuhan gizi mikro. Tujuan. Penelitian ini bertujuan untuk mengembangkan formulasi, menguji daya simpan, menganalisis kandungan zat gizi, dan menguji penerimaan konsumen dari biskuit yang dikembangkan, yaitu; berbasis campuran tepung terigu (TT), tepung ubi jalar ungu (TUJU), tepung kacang merah (TKM), dan tepung wijen (TW) sebagai alternatif produk MPASI. Metode. Desain penelitian adalah studi eksperimental dengan Rancangan Acak Lengkap (RAL). Penelitian dilakukan pada Mei-Juli 2017 di Laboratorium Gizi Kuliner STIK Sint Carolus dan Saraswati Indo Genetech, Bogor. Tahapan penelitian terdiri dari tiga tahap yaitu perancangan formula produk MPASI, analisis kandungan zat gizi dan uji daya simpan produk, serta analisis organoleptik dan penentuan produk terpilih. Data dianalisis menggunakan uji Kruskall Wallis untuk mengetahui perbedaan yang dimiliki oleh tiap produk yang dihasilkan. Hasil. Formulasi penambahan maksimal didapat dari tepung wijen dan tepung kacang merah sebesar 7,5 persen. Produk biskuit yang terpilih oleh 51,35 persen panelis adalah biskuit F367 dengan komposisi TT 30 persen, TUJU 60 persen, TKM 2,5 persen, dan TW 7,5 persen. Terdapat pengaruh yang signifikan terhadap warna, rasa, dan mutu tekstur dengan p-value ≤0,05. Hasil analisis kandungan zat gizi biskuit MPASI F367 seperti kadar abu, protein dan karbohidrat, fosfor, dan energi sudah memenuhi standar SNI 01-7111.2-2005. Daya simpan produk berlangsung selama 42 hari dengan mutu kerenyahan tergolong cukup renyah. Kesimpulan. Formulasi terpilih adalah F367 yang terdiri dari TT 30 persen, TUJU 60 persen, TKM 2,5 persen, dan TW 7,5 persen sebagai produk MPASI. Produk F367 ini dapat menjadi alternatif produk MPASI.
PENELITIAN ANEMIA PADA SIKLUS 270 HARI PERTAMA KEHIDUPAN DAN USIA IBU DENGAN BERAT BAYI LAHIR RENDAH
Authors: Aini Rahmatika Nur , Tamtomo Didik Gunawan , Hanim Diffah 
Published: February 2019

Latar belakang. Anemia merupakan tahap akhir defisiensi zat besi. Kekurangan zat besi pada siklus 270 hari pertama kehidupan dapat membawa dampak buruk pada periode kehidupan selanjutnya. WHO merekomendasikan seluruh wanita hamil agar mendapatkan suplementasi zat besi. Namun, faktanya prevalensi anemia masih tinggi pada kelompok ibu hamil. Tujuan. Penelitian ini bertujuan untuk menganalisis hubungan kejadian anemia pada 270 hari pertama kehidupan dan usia ibu terhadap berat bayi lahir. Metode. Penelitian dilaksanakan di tiga Puskesmas di Sukoharjo, Indonesia pada Febuari-April 2018. Pemilihan tiga Puskesmas dilakukan secara purposive sampling dengan jumlah populasi 670 ibu. Sebanyak 129 ibu terpilih, subjek merupakan ibu yang memiliki balita (12-24 bulan). Subjek diwawancara menggunakan kuesioner sosio demografi, sedangkan data anemia didapat dari buku KIA. Analisis multivariat menggunakan regresi logistik untuk mengetahui faktor yang paling berhubungan dengan berat bayi lahir. Penentuan rasio menggunakan Confidence Interval (CI) 95% untuk menentukan kekuatan hubungan. Nilai p <0.05 digunakan untuk menyatakan signifikansi statistik. Hasil. Dari 129 ibu, sebanyak 100 (77,5%) mengalami anemia pada siklus 0-90 hari; 83 (64,3%) pada siklus 91-180 hari; 123 (95,3%) pada siklus 181-270 hari; dan 73 (56,6%) memiliki usia risiko kehamilan. Hasil uji regresi logistik, anemia pada siklus 0-90 hari dan 91-180 hari tidak ada hubungan yang bermakna dengan berat bayi lahir (p>0.05), sedangkan anemia pada siklus 181-270 hari (p=0.01;OR=6.14) dan usia risiko kehamilan (p=0.03;OR=2.81) berhubungan dengan berat bayi lahir. Kekurangan zat besi pada siklus 181-270 hari pertama kehidupan dan usia ibu hamil yang rentan berkontribusi pada berat lahir bayi. Kesimpulan. Probabilitas ibu anemia pada siklus 181-270 hari pertama kehidupan dan memiliki usia risiko kehamilan dalam melahirkan bayi dengan Berat Bayi Lahir Rendah (BBLR) sebesar 7,63%.
Peran Suami dalam Menentukan Kesejahteraan Subjektif Istri pada Saat Hamil dan Melahirkan
Authors: Sudirman Sudirman , Puspitawati Herien , Muflikhati Istiqlaliyah 
Published: February 2019

Optimization of family functions can be realized by dividing tasks for each family member as an effort to improve the health and nutrition status of pregnant women so that they can reduce maternal and infant mortality in Indonesia. The objective of this study is to analyze the influence of the role of husband on the subjective well-being of wife with newborn baby. The study design used a cross sectional study and carried out in Tuppu Health Center, Lembang Subdistrict, Pinrang Regency, South Sulawesi Province by involving 110 wives in intact families and was having children up to 6 months of age; selected using simple random sampling method. Data were collected through interviews using questionnaires then were analyzed by descriptive and multiple regression test. The results of the study found that the average role of husbands when his wife was pregnant and giving birth is in the low category, especially in the dimensions of domestic roles and social roles. Wife's subjective well-being is in the medium category. Family typology based on husband's role and wife's subjective well-being when was pregnant and giving birth are mostly classified into type 2. Meanwhile, the duration of husband's education, family income and husband's role in domestic role and social role dimensions have a significant positive effect on subjective well-being of wife with newborn baby.
Kesejahteraan Keuangan Keluarga Usia Pensiun: Literasi Keuangan, Perencanaan Keuangan Hari Tua, dan Kepemilikan Aset
Authors: Aulia Nadia , Yuliati Lilik Noor , Muflikhati Istiqlaliyah 
Published: February 2019

This study aims to analyze the effect of financial literacy, retirement planning, and asset ownership on family’s financial wellbeing at retirment age. Sample in this research was 120 families with a husband or wife in retiress age (55-65 years old) as a respondent. Respondents were chosen purposively, 60 respondents in each urban and rural area. The research did in Bandar Lampung city as an urban area and Pringsewu district as a rural area. Data were analyzed using descriptive analysis, a independent sample t-test, and multiple linear regression. The result showed that level of education, job status, and average of income were different significant between urban and rural area, and average of the family in urban area was higher than rural area. Index average of financial literacy and financial well-being in rural area was lower than urban area. Percentage of retirement planning ownership of respondent’s in urban area was higher than respondents in rural area. Average of asset ownership (material asset and financial asset) also higher in urban than rural area. The factors that have positive significant effect on family’s financial wellbeing at retirees age were region, education, financial literacy, and retirement planning.
Resenha de: Zirker, Daniel. "Forging military identity in Culturaly Pluralistic Societies: quasi-ethnicity". Maryland: Lexington Books, 2015
Authors: Mathias Suzeley Kalil 
Published: February 2019

Resenha do livro organizado por Daniel Zirker: Zirker, Daniel. (2015) Forging military identity in Culturaly Pluralistic Societies: quasi-ethnicity. Maryland: Lexington Books, 133pp. ISBN 978-1-4985-0743-1
Estudos Estratégicos como Área de Conhecimento Científico
Authors: Figueiredo Eurico de Lima 
Published: February 2019

Este artigo aborda a questão das áreas de conhecimento cientifico no Brasil e propõe que os Estudos Estratégicos preenchem as condições necessárias para serem reconhecidos como uma área de conhecimento científico. Sustenta que os Estudos Estratégicos compreendem conjunto de conhecimentos inter-relacionados e coletivamente construídos. Defende que seu objeto de ensino e pesquisa é o complexo Defesa Nacional/Segurança Internacional. Preconiza que a natureza de seu objeto é de caráter político. Mostra que a área cumpre com as exigências de servir ao ensino e à pesquisa, além de gerar saberes que instrumentalizam suas aplicações práticas. Palavras-chave: Área de Conhecimento / Estudos Estratégicos / Defesa Nacional e Segurança Internacional. This article addresses the issue of scientific knowledge areas in Brazil and proposes that Strategic Studies fulfill the necessary conditions to be recognized as an area of scientific knowledge. It maintains that Strategic Studies include a set of interrelated and collectively built knowledge. It argues that its teaching and research object is the National Defense / International Security complex. It assumes the political nature of its object. It shows that the area meets the requirements to serve teaching and research, besides generating knowledge that instrumentalizes its practical applications.Keywords: Knowledge Area / Strategic Studies / National Defense and International Security.
Ontologia, Metodologia e Prioridades nos Estudos de Defesa
Authors: Rocha Antonio Jorge Ramalho da 
Published: February 2019

Este artigo combina as reflexões de um assíduo estudante de Relações Internacionais com a vivência de um professor que acumulou alguma experiência na gestão pública. Uma das vantagens da vida acadêmica é que a cada dia reduzimos a nossa ignorância, o que é gratificante, mesmo sabendo que jamais conheceremos tudo o que é relevante e útil – para não falar do que julgamos apenas interessante. Dividi minhas observações em pequenas seções, a bem da brevidade, “irmã do talento”, como nos lembrava Tchecov. Se não alcanço o talento, com disciplina imponho-me a brevidade. Já é algo. Em busca de leveza, reduzi as citações, mas compartilho uma lista de referências para os que quiserem se aprofundar nesses assuntos.
A Sociologia Funcionalista de Florestan Fernandes, os Tupinambás e as Novas Guerras
Authors: Palacios Jr. Alberto Montoya 
Published: February 2019

Esta pesquisa resgata a sociologia funcionalista de Florestan Fernandes, elaborada para análise da “função social da guerra na sociedade Tupinambá”. Enfatizamos os aspectos teórico-conceituais daquela obra que contribuam para a pesquisa das “novas guerras” nas Relações Internacionais contemporâneas. This research revisits the functionalist sociology of Florestan Fernandes, formulated for the analysis of the “social function of the tupinambá warfare”. We hallmarked the theoretical and conceptual aspects of such work that contributes on the subject of the new wars on the Contemporary International Relations.
Resenha de: Chamayou, Grégoire. 2015. Teoria do Drone
Authors: Peron Alcides Eduardo dos Reis 
Published: February 2019

Nos últimos anos assistimos a um sem número de informações envolvendo diversas possibilidades de emprego de drones, conformando um imaginário absolutamente positivo dessa tecnologia para a sociedade. Observando esse contexto, mas também consciente de toda uma trajetória política, social e epistêmica que embasa o desenvolvimento das tecnologias e dispositivos militares, é que o filósofo Grégoire Chamayou, desenvolve a sua teoria sobre os drones, ao mesmo tempo em que advoga em favor de uma “teoria crítica” dos armamentos.
Türkiye Taşınmaz Değerleme Sisteminin Etkinliğinin Araştırılması
Authors: ERDEM Nuri 
Published: February 2019

Vergilendirme, kamulaştırma, özelleştirme, tescile esas işlemler, irtifak hakkı tesisi gibi kamusal uygulamalar ile sermaye piyasası, bankacılık, kredilendirme, sigortacılık gibi özel sektör uygulamalarında taşınmaz değerlerine ihtiyaç duyulmaktadır. Bu nedenle, ülkelerin gerek taşınmaz pazarlarının şeffaflığını sağlama gerekse kamu ve özel sektör uygulamalarının adaletli bir şekilde gerçekleştirilmesini temin etme amacıyla değerleme altyapılarını oluşturmaları büyük önem arz etmektedir. Ülkemizin taşınmaz değerleme sistemi incelendiğinde, bu alanda sağlıklı bir mevzuatın ve kurumsal yapılanmanın bulunmadığı, değerlemede ihtiyaç duyulan veritabanlarının ve değerleme modellerinin oluşturulamadığı görülmektedir. Bu çalışmada, ülkemizde taşınmaz değerleme alanında yürütülen faaliyetlere ilişkin mevcut durum tespiti ile bu alanda yaşanan sorunların ortaya koyulması ve çözüm önerilerinin geliştirilmesi hedeflenmiştir.