bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer
Authors: Zhang Kecheng , Lu Canrong , Huang Xiaohui , Cui Jianxin , Li Jiyang , Gao Yunhe , Liang Wenquan , Liu Yi , Sun Yang , Liu Hanxuan , Wei Bo , Chen Lin 
Published: February 2019

Background: The clinical relevance and biological role of tissular AOC4P in gastric cancer (GC) remains to be clarified. Methods: The association between AOC4P expression and clinicopathological characteristics was investigated. In vitro, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, wound healing and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to explore the biological effects of AOC4P on GC cell proliferation, migration, invasion, and apoptosis in MGC-803 and BGC-823 cell lines. In vivo, animal experiments were conducted to confirm the in vitro findings. Quantitative real-time polymerase chain reaction, western blotting, and immunofluorescence were used to investigate the potential mechanisms. Results: Expression levels of AOC4P were significantly higher in tumor tissues than in noncancerous tissues, and patients with high levels of AOC4P had poor overall and disease-free survival. AOC4P expression was correlated with lymphovascular invasion. In vitro, knockdown of AOC4P inhibited tumor cell proliferation, migration, and invasion, and promoted apoptosis of MGC-803 and BGC-823 cells. In vivo, BGC-823 cells transfected with AOC4P siRNA formed smaller and lighter tumors than BGC-823 cells transfected with negative control siRNA in severe combined immunodeficiency mice. Additionally, the si- AOC4P group had less proliferating cells and more apoptotic cells in tumor xenografts compared with the negative control. Mechanistically, knockdown of AOC4P decreased the expression of vimentin and MMP9, while increasing the expression of E-cadherin. Immunofluorescence confirmed the relationship between AOC4P expression and E-cadherin, vimentin, and MMP9 levels in clinical GC specimens. Conclusions: AOC4P promotes tumorigenesis and progression partly through epithelial–mesenchymal transition in GC. Additionally, AOC4P may serve as a prognostic biomarker for clinical decision making.
Achieved low-density lipoprotein cholesterol level and stroke risk: A meta-analysis of 23 randomised trials
Authors: Shin Jaewon , Chung Jong-Won , Jang Hyun-Soon , Lee Juneyoung , Hong Keun-Sik , Bang Oh Young , Kim Gyeong-Moon , Seo Woo-Keun 
Published: February 2019

Abstract

Aims
Lowering the low-density lipoprotein cholesterol level reduces the risk of stroke, but it has not been clear whether the stroke risk would continuously decrease by lowering low-density lipoprotein cholesterol to a very low level. The purpose of this study was to evaluate the association between achieved low-density lipoprotein cholesterol levels and stroke risk.

Methods and results
A systematic search of MEDLINE, EMBASE and Cochrane Library databases was conducted to identify randomised controlled trials that tested cholesterol-lowering pharmacological therapies and reported both achieved low-density lipoprotein cholesterol levels and stroke outcomes. A meta-regression analysis was conducted to assess the linear association between the achieved low-density lipoprotein cholesterol levels and stroke risk. In addition, we evaluated pooled estimates of low-density lipoprotein cholesterol-lowering effect stratified by achieved low-density lipoprotein cholesterol levels of active arms. A total of 222,149 participants in 23 trials (52 arms of 26 studies) were included. The meta-regression analysis showed that each 1 mmol/L decrease in the achieved low-density lipoprotein cholesterol level (down to 0.78 mmol/L) was associated with a significant reduction of 23.5% (slope 0.235, 95% confidence interval 0.007–0.464, P = 0.044) in stroke risk. Irrespective of achieved low-density lipoprotein cholesterol levels in the active arms, the effects of lowering the low-density lipoprotein cholesterol level on stroke risk were significant and consistent (test for subgroup difference, P = 0.23, I2 = 31%). However, there was no significant increase in haemorrhagic stroke risk with lower achieved low-density lipoprotein cholesterol levels.

Conclusion
In this meta-analysis of randomised controlled trials, the stroke risk monotonically reduced with lowering of low-density lipoprotein cholesterol to very low levels.
Increased mitochondrial DNA4977-bp deletion in catheterization laboratory workers with long-term low-dose exposure to ionizing radiation
Authors: Borghini Andrea , Vecoli Cecilia , Piccaluga Emanuela , Guagliumi Giulio , Picano Eugenio , Andreassi Maria Grazia 
Published: February 2019

Aims Ionizing radiation may lead to mitochondrial DNA (mtDNA) mutations and changes in mtDNA content in cells, major driving mechanisms for carcinogenesis, vascular aging and neurodegeneration. The aim of this study was to investigate the possible induction of common mitochondrial deletion (mtDNA4977) and mtDNA copy number (mtDNA-CN) changes in peripheral blood of personnel working in high-volume cardiac catheterization laboratories (Cath Labs). Methods A group of 147 Cath Lab workers (median individual effective dose = 16.8 mSv, for the 41 with lifetime dosimetric record) and 74 unexposed individuals were evaluated. The occupational radiological risk score was computed for each subject on the basis of the length of employment, individual caseload and proximity to the radiation source. mtDNA4977 deletion and mtDNA-CN were assessed by using quantitative real-time polymerase chain reaction. Results Increased levels of mtDNA4977 deletion were observed in high-exposure Cath Lab workers compared with unexposed individuals ( p < 0.0001). Conversely, mtDNA-CN was significantly greater in the low-exposure workers ( p = 0.003). Occupational radiological risk score was positively correlated with mtDNA4977 deletion (Spearman's r = 0.172, p = 0.03) and inversely correlated with mtDNA-CN (Spearman's r = –0.202, p = 0.01). In multiple regression model, occupational radiological risk score emerged as significant predictor of high levels of mtDNA4977 deletion (ß coefficient = 0.236, p = 0.04). Conclusion mtDNA4977 deletion is significantly high in Cath Lab personnel. Beyond the well-recognized nuclear DNA, mtDNA damage might deserve attention as a pathogenetic molecular pathway and a potential therapeutic target of ionizing radiation damage.
A prospective RCT comparing combined chromoendoscopy with water exchange (CWE) vs water exchange (WE) vs air insufflation (AI) in adenoma detection in screening colonoscopy
Authors: Leung JW , Yen AW , Jia H , Opada C , Melnik A , Atkins J , Feller C , Wilson MD , Leung FW 
Published: February 2019

BackgroundA low adenoma detection rate (ADR) increases risks of interval cancers (ICs). Proximal colon flat polyps, e.g. serrated lesions (SLs), are difficult to find. Missed proximal colon flat lesions likely contribute to IC.AimsWe compared chromoendoscopy with water exchange (CWE), water exchange (WE) and air insufflation (AI) in detecting adenomas in screening colonoscopy.MethodsAfter split‐dose preparation, 480 veterans were randomized to AI, WE and CWE.ResultsPrimary outcome of proximal ADR (55.6% vs 53.4% vs 52.2%, respectively) were similar in all groups. Adenoma per colonoscopy (APC) and adenoma per positive colonoscopy (APPC) were comparable. Detection rate of proximal colon SLs was significantly higher for CWE and WE than AI (26.3%, 23.6% and 11.3%, respectively, p = 0.002). Limitations: single operator; SLs only surrogate markers of but not IC.ConclusionsWhen an endoscopist achieves high‐quality AI examinations with overall ADR twice (61.6%) the recommended standard (30%), use of WE and CWE does not produce further improvement in proximal or overall ADR. Comparable APC and APPC confirm equivalent withdrawal inspection techniques. WE alone is sufficient to significantly improve detection of proximal SLs. The impact of increased detection of proximal SLs by WE on prevention of IC deserves to be studied. This study is registered at ClinicalTrial.gov (NCT#01607255).
Training interventions to improve general hospital care for older people with cognitive impairment: systematic review
Authors: Abley Clare , Dickinson Claire , Andrews Zoe , Prato Laura , Lindley Lyndsay , Robinson Louise 
Published: February 2019

BackgroundIn response to increasing numbers of older people in general hospitals who have cognitive impairment such as dementia and delirium, many hospitals have developed education and training programmes to prepare staff for this area of clinical practice.AimsTo review the evidence on educational interventions on hospital care for older people with cognitive impairment.MethodA mixed methods systematic review and narrative synthesis was undertaken. The following electronic databases were searched: Medline, Embase, CINAHL, PsycINFO, EBM Reviews, ASSIA and Scopus, as well as Health Management Information Consortium (HMIC), ProQuest, PubMed and SCIE: Social Care Online. Initial searches were run in August 2014 (update search September 2016). Titles and abstracts of studies retrieved were screened independently. The full text of eligible studies were then independently assessed by two review team members. All included studies were assessed using a standard quality appraisal tool.ResultsEight studies relating to delirium, six on dementia and two on delirium and dementia were included, each testing the use of a different educational intervention. Overall, the quality of the studies was low. In relation to delirium, all studies reported a significant increase in participants' knowledge immediately post-intervention. Two of the dementia studies reported an increase in dementia knowledge and dementia confidence immediately post-intervention.ConclusionsThe variety of outcomes measured makes it difficult to summarise the findings. Although studies found increases in staff knowledge, there is insufficient evidence to conclude that educational interventions for staff lead to improved patient outcomes.Declaration of interestNone.
Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients 60 Years of Age and Younger: Results of the Intergroup ANOCEF-GOELAMS Randomized Phase II PRECIS Study
Authors: Houillier Caroline , Taillandier Luc , Dureau Sylvain , Lamy Thierry , Laadhari Mouna , Chinot Olivier , Moluçon-Chabrot Cecile , Soubeyran Pierre , Gressin Remy , Choquet Sylvain , Damaj Gandhi , Thyss Antoine , Abraham Julie , Delwail Vincent , Gyan Emmanuel , Sanhes Laurence , Cornillon Jérôme , Garidi Reda , Delmer Alain , Tanguy Marie-Laure , Al Jijakli Ahmad , Morel Pierre , Bourquard Pascal , Moles Marie-Pierre , Chauchet Adrien , Gastinne Thomas , Constans Jean-Marc , Langer Adriana , Martin Antoine , Moisson Patricia , Lacomblez Lucette , Martin-Duverneuil Nadine , Delgadillo Daniel , Turbiez Isabelle , Feuvret Loïc , Cassoux Nathalie , Touitou Valérie , Ricard Damien , Hoang-Xuan Khê , Soussain Carole ,   on behalf of the Intergroupe GOELAMS–ANOCEF and the LOC Network for CNS Lymphoma
Published: February 2019

PURPOSE To determine the efficacy and toxicity of chemoimmunotherapy followed by either whole-brain radiotherapy (WBRT) or intensive chemotherapy and autologous stem-cell transplantation (ASCT) as a first-line treatment of primary CNS lymphoma (PCNSL). PATIENTS AND METHODS Immunocompetent patients (18 to 60 years of age) with untreated PCNSL were randomly assigned to receive WBRT or ASCT as consolidation treatment after induction chemotherapy consisting of two cycles of R-MBVP (rituximab 375 mg/m2 day (D) 1, methotrexate 3 g/m2 D1; D15, VP16 100 mg/m2 D2, BCNU 100 mg/m2 D3, prednisone 60 mg/m2/d D1-D5) followed by two cycles of R-AraC (rituximab 375 mg/m2 D1, cytarabine 3 g/m2/D, D1, and D2). Intensive chemotherapy consisted of thiotepa (250 mg/m2/d D9; D8; D7), busulfan (8 mg/kg D6 through D4), and cyclophosphamide (60 mg/kg/d D3; D2). WBRT delivered 40 Gy (2 Gy/fraction). The primary end point was 2-year progression-free survival. Cognitive outcome was the main secondary end point. Analysis was intention to treat in a noncomparative phase II trial. RESULTS Between October 2008 and February 2014, 140 patients were recruited from 23 French centers. Both WBRT and ASCT met the predetermined threshold (among the first 38 patients in each group, at least 24 patients were alive and disease free at 2 years). The 2-year progression-free survival rates were 63% (95% CI, 49% to 81%) and 87% (95% CI, 77% to 98%) in the WBRT and ASCT arms, respectively. Toxicity deaths were recorded in one and five patients after WBRT and ASCT, respectively. Cognitive impairment was observed after WBRT, whereas cognitive functions were preserved or improved after ASCT. CONCLUSION WBRT and ASCT are effective consolidation treatments for patients with PCNSL who are 60 years of age and younger. The efficacy end points tended to favor the ASCT arm. The specific risk of each procedure should be considered.
Markedly Reduced Risk of Internal Malignancies in Patients With Vitiligo: A Nationwide Population-Based Cohort Study
Authors: Bae Jung Min , Chung Kee Yang , Yun Sook Jung , Kim Heesu , Park Byung Cheol , Kim Joung Soo , Seo Soo Hong , Ahn Hyo Hyun , Lee Dong-Youn , Kim You Chan , Park Hyang Joon , Kim Miri 
Published: February 2019

PURPOSE Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated. PATIENTS AND METHODS We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. All patients age 20 years or older with vitiligo who had at least two contacts with a physician from 2009 to 2016, during which a principal diagnosis was made, were identified (vitiligo group). Controls were randomly selected (two per patient with vitiligo) after frequency matching with the vitiligo group for age and sex during the same period (control group). RESULTS A total of 101,078 patients with vitiligo and 202,156 controls without vitiligo were included. The incidence rates of internal malignancies were 612.9 and 708.9 per 100,000 person-years in the vitiligo and control groups, respectively. Patients with vitiligo showed a significantly reduced risk of overall internal malignancies (hazard ratio [HR], 0.86; 95% CI, 0.82 to 0.89; P < .001) compared with controls without vitiligo after adjustments for age, sex, and comorbidities. With regard to organ-specific malignancies, patients with vitiligo showed a remarkably decreased risk of cancer in the colon and rectum (HR, 0.62; 95% CI, 0.55 to 0.69; P < .001), ovary (HR, 0.62; 95% CI, 0.46 to 0.83; P < .001), and lung (HR, 0.75; 95% CI, 0.65 to 0.86; P < .001). CONCLUSION Vitiligo was associated with a reduced risk of overall internal malignancies. These findings suggest that autoimmune diseases, including vitiligo, may provide immune surveillance for the development of cancer beyond the targeted organ.
Magnetic Sagnac Interference Measurements of Agglomeration and Deagglomeration of Magnetic Nanoparticles
Authors: Watarai Hitoshi , Chen Ziyu 
Published: February 2019

Abstract
Magnetic field induced Sagnac interference was observed for the COOH modified iron oxide magnetic nanoparticles (MNPs) dispersed in water. The effect of cationic surfactants showing agglomeration and deagglomeration of the MNPs was clearly detected by the phase shift due to the magnetic orientation of MNPs. The observed phase shifts were discussed by using Langevin parameters.
Managing symptoms associated with the redundant distal colon and rectum: a pilot scoping exercise
Authors: Lamb Karen A , Lodge Jen 
Published: February 2019

Background: During stoma formation, the redundant distal colon and rectum (RDCR) is often left in situ. This is associated with symptoms that can be problematic and difficult to manage. Aims: This questionnaire aimed to determine patient experience of RDCR-associated symptoms, their impact and how they are managed. Methods: Data were collected from a self-selecting convenience sample at an information event using a mixed-methods questionnaire, before being collated in a spreadsheet for framework analysis. Results: The questionnaire was completed by 19 patients. The severity of symptoms' impact varied widely. Common problems included rectal leakage, odour and sore skin, as well as psychosocial symptoms like anxiety and depression. Some patients had undergone investigations. Management usually involved bearing down over the toilet, as well as Glycerin, Microlax and phosphate suppositories and enemas. Conclusions: This small pilot study highlighted the variation in symptoms and their severity in RDCR. Further research into this population is required to inform management strategies and develop a care pathway.
A Participação Feminina nos Conselhos de Administração das Empresas Brasileiras: uma análise das características de formação acadêmica e experiência profissional à luz da teoria do capital humano
Authors: Lazzaretti Kellen , Godoi Christiane Kleinübing 
Published: February 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2012.1.1.4059.159-186O objetivo do estudo reside em analisar as características de formação acadêmica e de experiência profissional que contribuem para a participação de mulheres nos Conselhos de Administração (CAs) das empresas brasileiras de capital aberto, à luz da teoria do capital humano. O estudo analisou a composição de gênero de 410 empresas de capital aberto listadas no ano de 2011 na BM&FBovespa e os currículos das 158 conselheiras que o compõem, por meio da técnica de análise de conteúdo. Os resultados apontaram que 7,3% dos assentos existentes nos CAs são ocupados por mulheres. A análise curricular mostrou que a maioria dessas mulheres são graduadas, possuem experiências profissionais diversas e muitas possuem experiências anteriores como conselheiras em outras empresas. Apesar do investimento em capital humano realizado por estas mulheres, o principal motivo para indicação a um assento nos CAs brasileiros é o vínculo familiar, representando 40% do total.
MLTI Education in China: Current Situation, Challenges and Countermeasures
Authors: Qinglin MA , Xin FU 
Published: February 2019

Abstract
Based on the Guideline for MTI Training Program established by China National Committee for MTI (Master of Translation and Interpreting) Education, this research makes a successive survey on the status quo of master education of legal translators and interpreters from 2014-2016 to trace the changes and problems revealed in the five major universities of political science and law in China. By comparing and analyzing the information and facts collected on the training target, curriculum setting, teaching staff, platform construction, practical training as well as the employment in those five universities, the authors sort out the diversified advantages and features of the five law schools, and probe into the existing problems and difficulties in common. On the grounds of the survey and interview conducted by the authors in the recent years, the authors put forward the solutions and suggestions on the improvement and future development of Chinese MTI education.
The Web as Corpus and Online Corpora for Legal Translations
Authors: Giampieri Patrizia 
Published: February 2019

AbstractLegal language is hallmarked by a pedantic and user-unfriendly jargon whose constructs are all but intuitive, not to mention the legal system specificity which makes it unique in every country. Second language (L2) learners or scholars, hence, may find it difficult to understand the language of the law; whereas translators may consider legal lexical phrases and patterns rather intricate to deal with. The literature claims that a practical way to deepen language knowledge can be found in the Web considered as corpus and in online corpora. This paper is aimed at exploring whether commercial search engines, Web concordancers and online specialised corpora can tackle the issues revolving around legal language. In particular, it will investigate whether Google advanced search and the Leeds Web concordancer can be used to meet the requirements of legal language learners, scholars and translators. Furthermore, it will address legal language queries (and results) in an online specialised corpus: the COCA. This paper will provide instances of the soundness of the above-mentioned online resources, especially when used jointly as cross-analysis tools. The shortcomings of one can, in fact, be compensated for by the other(s).
Legislative History as an Interpretative Tool in Uni- and Multinlingual Legal Systems (Based on the Example of Poland and the UE)
Authors: Bielska-Brodziak Agnieszka , Paluszek Karolina 
Published: February 2019

AbstractThe paper aims to analyse and compare the interpretative function of legislative history in the judicial activity of the European Court of Justice and Polish courts.The authors have analysed judgments of the respective courts, focusing on the role of legislative history in their argumentation. In the Polish and European doctrine, the usefulness oftravaux preparatoireshas been underestimated. Nevertheless, legislative history may provide arguments important in judicial reasoning both in uni- and multilingual legal systems. However, its importance and functions in Polish and European cases examined herein are different. The research conducted enables a better understanding of the interpretative value of legislative history in legal interpretation and can result in more frequent use of this tool in the judicial activity of national and European courts.
Interpretation as a Pervading Problem in Legal Translation
Authors: Flöter-Durr Margarete 
Published: February 2019

Abstract
In the context of the quantitative shift in the translation field, both pragmatic and legal, this article aims to return to the role of interpretation and meaning concepts and to place them back at the centre of legal translation concerns. Starting from the observation of the necessity of interpretation, it is a question of highlighting the social anchoring of any translation as an act of communication and the inadequacy of the paradigm of equivalence (Sandrini, 2017) which results from it. Based on Schütz’s theory, the concepts of relevance and stock of knowledge and their role in translation will be highlighted (Schütz, 2004b). Finally, the outlines of a practical method of translation based on relevance and usage (Wittgenstein, 2004) will be outlined.
The operator approach to the truncated multidimensional moment problem
Authors: Zagorodnyuk Sergey M. 
Published: February 2019

Abstract
We study the truncated multidimensional moment problem with a general type of truncations. The operator approach to the moment problem is presented. The case where the associated operators form a commuting self-adjoint tuple is characterized in terms of the given moments. The case of the dimensional stability is characterized in terms of the prescribed moments as well. Some sufficient conditions for the solvability of the moment problem are presented. A construction of the corresponding solution is described by algorithms. Numerical examples of the construction are provided.