bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France
Authors: Giral Philippe , Neumann Anke , Weill Alain , Coste Joël 
Published: June 2019

Abstract

Aims
The role of statin therapy in primary prevention of cardiovascular disease in persons older than 75 years remains a subject of debate with little evidence to support or exclude the benefit of this treatment. We assessed the effect of statin discontinuation on cardiovascular outcomes in previously adherent 75-year-olds treated for primary prevention.

Methods and results
A population-based cohort study using French national healthcare databases was performed, studying all subjects who turned 75 in 2012–14, with no history of cardiovascular disease and with a statin medication possession ratio ≥80% in each of the previous 2 years. Statin discontinuation was defined as three consecutive months without exposure. The outcome was hospital admission for cardiovascular event. The hazard ratio comparing statin discontinuation with continuation was estimated using a marginal structural model adjusting for both baseline and time-varying covariates (cardiovascular drug use, comorbidities, and frailty indicators). A total of 120 173 subjects were followed for an average of 2.4 years, of whom 17 204 (14.3%) discontinued statins and 5396 (4.5%) were admitted for a cardiovascular event. The adjusted hazard ratios for statin discontinuation were 1.33 [95% confidence interval (CI) 1.18–1.50] (any cardiovascular event), 1.46 (95% CI 1.21–1.75) (coronary event), 1.26 (95% CI 1.05–1.51) (cerebrovascular event), and 1.02 (95% CI 0.74–1.40) (other vascular event).

Conclusion
Statin discontinuation was associated with a 33% increased risk of admission for cardiovascular event in 75-year-old primary prevention patients. Future studies, including randomized studies, are needed to confirm these findings and support updating and clarification of guidelines on the use of statins for primary prevention in the elderly.
The outer membrane glycolipids of bacteria from cold environments: isolation, characterization, and biological activity
Authors: Casillo Angela , Parrilli Ermenegilda , Tutino Maria Luisa , Corsaro Maria Michela 
Published: June 2019

ABSTRACTLipopolysaccharides (LPSs) are the main components of the external leaflet of the outer membrane of Gram-negative bacteria. Microorganisms that colonize permanently or transiently cold habitats have evolved an array of structural adaptations, some of which involve components of bacterial membranes. These adaptations assure the perfect functionality of the membrane even at freezing or sub-freezing growth temperatures. This review summarizes the state-of-the-art information concerning the structural features of the LPSs produced by cold-adapted bacteria. The LPS structure has recently been elucidated from species mainly belonging to Gammaproteobacteria and Flavobacteriaceae. Although the reported structural heterogeneity may arise from the phylogenetic diversity of the analyzed source strains, some generalized trends can be deduced. For instance, it is clear that only a small portion of LPSs displays the O-chain. In addition, the biological activity of the lipid A portion from several cold-adapted strains is reported.
Identifying Five Archetypes of Interaction Design Professionals and Their Universal Design Expertise
Authors: Begnum Miriam Eileen Nes , Pettersen Lene , Sørum Hanne 
Published: June 2019

Abstract

Systems and services based on Information and Communications Technology (ICT) are now prevalent in our daily lives. Digital transformations have been, and are still being, initiated across private and public sectors. As such, the consequences of digital exclusion are severe and may block access to key aspects of modern life, such as education, employment, consumerism and health services. In order to combat this, regions and countries such as the USA, Canada, EU and Scandinavia have all legislated universal design (UD) in relation to ICT, in order to ensure as many citizens as possible have the opportunity to access and use digital information and services. However, there has been limited research into how higher educational programs address legislated accessibility responsibilities. This paper looks into the discipline of interaction design (IxD). IxD is the design domain focused on ‘how human beings relate to other human beings through the mediating influence of products’ (Buchanan, R. (2001) Designing research and the new learning. Des. Issues, 17, 3–23). The study presents an analysis of Norwegian higher educational programs within IxD. Based on document analysis, we map the skillsets the study programs state to deliver and investigate to what degree UD expertise is included. Our findings indicate the study programs do not deliver adequate training in UD, in order to fulfill the professional responsibilities related to ICT accessibility. From our findings, we extrapolate five ‘archetypes’ of interaction designers. These personas-like analytical constructs hold slightly different characteristics. For each of the five, we propose UD expertise fitting key skillsets. We hope our contributions are useful both for the higher education sector and the industry and will contribute to raised awareness of UD skills so they can educate interaction designers in their different industry roles with required competences.

RESEARCH HIGHLIGHTS
We indicate the current content of interaction design (IxD) programs in higher education and document the lacking focus on universal design (UD). We identify five different archetypes of interaction designers being educated in such programs. We describe key skillsets and strengths for each archetype. We propose UD expertise for the (IxD) profession and link UD expertise to archetype skillsets to emphasize relevance.
Risk Factors for Multidrug-Resistant Acinetobacter baumannii Infections in a Mass Burn Casualty Incident
Authors: Yeong Eng-Kean , Huang Wei-Lieh 
Published: June 2019

AbstractThey investigated the risk factors of multidrug-resistant Acinetobacter baumannii infections in 33 burn patients in a mass burn casualty. The independent variables included sex, burn size, vancomycin, ampicillin/sulbactam, cefazolin, meropenem, third-/fourth-generation cephalosporin, the number of classes of antibiotic used, and the number of days of antibiotic use. Multidrug-resistant A. baumannii infection was the outcome variable. Logistic regressions and structural equation model were used for statistical analysis. The average age was 21.7 years (range, 17–32 years; M = 11 [33%], F = 22 [67%]; mean burn area, 42% of the total body surface area; study period, June 28, 2015 to July 31, 2015). The incidence of infection was 39% (n = 13/33). For every percent increase in burn size, the odds of developing A. baumannii infections increased by 1.1 (P < .05). Similarly, the odds increased by 2.5 in every number increase in the classes of antibiotic used, by 1.2 in everyday increase in the days of antibiotic used, and by 12 in patients treated with vancomycin (P < .05). The correlations of these risk factors were demonstrated in a hypothetical structural equation model (P-value of chi-squared test > .05 and root mean square error of approximation < 0.05) in which burn size was the fundamental risk factor of multidrug-resistant A. baumannii infections. The model did not predict the emergence of multidrug-resistant A. baumannii infections. Conclusively, the risks of multidrug-resistant A. baumannii infections in burns are correlated with burn size, the number of classes of antibiotic used, the number of days of antibiotic use, and the prior use of vancomycin.
Postglacial Colonization of Northern Coastal Habitat by Bottlenose Dolphins: A Marine Leading-Edge Expansion?
Authors: Nykänen Milaja , Kaschner Kristin , Dabin Willy , Brownlow Andrew , Davison Nicholas J , Deaville Rob , Garilao Cristina , Kesner-Reyes Kathleen , Gilbert M Thomas P , Penrose Rod , Islas-Villanueva Valentina , Wales Nathan , Ingram Simon N , Rogan Emer , Louis Marie , Foote Andrew D 
Published: June 2019

AbstractOscillations in the Earth’s temperature and the subsequent retreating and advancing of ice-sheets around the polar regions are thought to have played an important role in shaping the distribution and genetic structuring of contemporary high-latitude populations. After the Last Glacial Maximum (LGM), retreating of the ice-sheets would have enabled early colonizers to rapidly occupy suitable niches to the exclusion of other conspecifics, thereby reducing genetic diversity at the leading-edge. Bottlenose dolphins (genus Tursiops) form distinct coastal and pelagic ecotypes, with finer-scale genetic structuring observed within each ecotype. We reconstruct the postglacial colonization of the Northeast Atlantic (NEA) by bottlenose dolphins using habitat modeling and phylogenetics. The AquaMaps model hindcasted suitable habitat for the LGM in the Atlantic lower latitude waters and parts of the Mediterranean Sea. The time-calibrated phylogeny, constructed with 86 complete mitochondrial genomes including 30 generated for this study and created using a multispecies coalescent model, suggests that the expansion to the available coastal habitat in the NEA happened via founder events starting ~15 000 years ago (95% highest posterior density interval: 4 900–26 400). The founders of the 2 distinct coastal NEA populations comprised as few as 2 maternal lineages that originated from the pelagic population. The low effective population size and genetic diversity estimated for the shared ancestral coastal population subsequent to divergence from the pelagic source population are consistent with leading-edge expansion. These findings highlight the legacy of the Late Pleistocene glacial cycles on the genetic structuring and diversity of contemporary populations.
Overdiagnosis and Lives Saved by Reflex Testing Men With Intermediate Prostate-Specific Antigen Levels
Authors: Gulati Roman , Morgan Todd M , A'mar Teresa , Psutka Sarah P , Tosoian Jeffrey J , Etzioni Ruth 
Published: June 2019

Abstract

Background
Several prostate cancer (PCa) early-detection biomarkers are available for reflex testing in men with intermediate prostate-specific antigen (PSA) levels. Studies of these biomarkers typically provide information about diagnostic performance but not about overdiagnosis and lives saved, the primary drivers of associated harm and benefit.

Methods
We projected overdiagnoses and lives saved using an established microsimulation model of PCa incidence and mortality with screening and treatment efficacy based on randomized trials. We used this framework to evaluate four urinary reflex biomarkers (measured in 1112 men presenting for prostate biopsy at 10 US academic or community clinics) and two hypothetical ideal biomarkers (with 100% sensitivity or specificity for any or for high-grade PCa) at one-time screening tests at ages 55 and 65 years.

Results
Compared with biopsying all men with elevated PSA, reflex testing reduced overdiagnoses (range across ages and biomarkers = 8.8–60.6%) but also reduced lives saved (by 7.3–64.9%), producing similar overdiagnoses per life saved. The ideal biomarker for high-grade disease improved this ratio (by 35.2% at age 55 years and 42.0% at age 65 years). Results were similar under continued screening for men not diagnosed at age 55 years, but the ideal biomarker for high-grade disease produced smaller incremental improvement.

Conclusions
Modeling is a useful tool for projecting the implications of using reflex biomarkers for long-term PCa outcomes. Under simplified conditions, reflex testing with urinary biomarkers is expected to reduce overdiagnoses but also produce commensurate reductions in lives saved. Reflex testing that accurately identifies high-grade PCa could improve the net benefit of screening.
Hiatal hernia and morbid obesity—‘Roux-en-Y gastric bypass’ the one step solution
Authors: Khan Mohsin , Mukherjee Aloy J 
Published: June 2019

Abstract
Obesity and hiatal hernia go hand in hand as siblings. Morbidly obese patients commonly have gastroesophageal reflux (GERD) and associated hiatal hernias (HH). The gold standard for all symptomatic reflux patients is still surgical correction of the paraesophageal hernia, hiatal closure and fundoplication. Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective surgical treatment for morbid obesity and is known to effectively control symptoms of gastroesophageal reflux (GERD). It appears to be safe and feasible and becoming more common. Moreover, LRYGB plus Hiatus hernia repair (HHR) appears to be a good alternative for HH patients suffering from morbid obesity as well than antireflux surgery alone because of the additional benefit of significant weight loss and improvement of obesity related co-morbidity. One patient suffering from giant hiatal hernia and morbid obesity where a combined LRYGB and HHR without mesh was performed is presented in this paper.
Linear analysis of the non-axisymmetric secular gravitational instability
Authors: Shadmehri Mohsen , Oudi Razieh , Rastegarzadeh Gohar 
Published: June 2019

Abstract
In protoplanetary discs (PPDs) consisting of gas and dust particles, fluid instabilities induced by the drag force, including secular gravitational instability (SGI), can facilitate planet formation. Although SGI subject to the axisymmetric perturbations was originally studied in the absence of gas feedback and it then generalized using a two-fluid approach, the fate of the non-axisymmetric SGI, in either case, is an unexplored problem. We present a linear perturbation analysis of the non-axisymmetric SGI in a PPD by implementing a two-fluid model. We explore the growth of the local, non-axisymmetric perturbations using a set of linearized perturbation equations in a sheared frame. The non-axisymmetric perturbations display a significant growth during a finite time interval even when the system is stable against the axisymmetric perturbations. Furthermore, the surface density perturbations do not show the continuous growth but are temporally amplified. We also study cases where the dust component undergoes amplification whereas the gas component remains stable. The amplitude amplification, however, strongly depends on the model parameters. In the minimum mass solar nebula (MMSN), for instance, the dust fluid amplification at the radial distance 100 au occurs when the Stokes number is about unity. But the amplification factor reduces as the dust and gas coupling becomes weaker. Furthermore, perturbations with a larger azimuthal wavelength exhibit a larger amplification factor.
The Magellanic System: the puzzle of the leading gas stream
Authors: Tepper-García Thor , Bland-Hawthorn Joss , Pawlowski Marcel S , Fritz Tobias K 
Published: June 2019

ABSTRACT
The Magellanic Clouds (MCs) are the most massive gas-bearing systems falling into the Galaxy at the present epoch. They show clear signs of interaction, manifested in particular by the Magellanic Stream, a spectacular gaseous wake that trails from the MCs extending more than 150° across the sky. Ahead of the MCs is the ‘Leading Arm’ usually interpreted as the tidal counterpart of the Magellanic Stream, an assumption we now call into question. We revisit the formation of these gaseous structures in a first-infall scenario, including for the first time a Galactic model with a weakly magnetized, spinning hot corona. In agreement with previous studies, we recover the location and the extension of the Stream on the sky. In contrast, we find that the formation of the Leading Arm – that is otherwise present in models without a corona – is inhibited by the hydrodynamic interaction with the hot component. These results hold with or without coronal rotation or a weak, ambient magnetic field. Since the existence of the hot corona is well established, we are led to two possible interpretations: (i) the Leading Arm survives because the coronal density beyond 20 kpc is a factor ≳10 lower than required by conventional spheroidal coronal X-ray models, in line with recent claims of rapid coronal rotation; or (ii) the ‘Leading Arm’ is cool gas trailing from a frontrunner, a satellite moving ahead of the MCs, consistent with its higher metallicity compared to the trailing stream. Both scenarios raise issues that we discuss.
The escape fraction of ionizing photons during the Epoch of Reionization: observability with the Square Kilometre Array
Authors: Seiler Jacob , Hutter Anne , Sinha Manodeep , Croton Darren 
Published: June 2019

Abstract
One of the most important parameters in characterizing the Epoch of Reionization, the escape fraction of ionizing photons, fesc, remains unconstrained both observationally and theoretically. With recent work highlighting the impact of galaxy-scale feedback on the instantaneous value of fesc, it is important to develop a model in which reionization is self-consistently coupled to galaxy evolution. In this work, we present such a model and explore how physically motivated functional forms of fesc affect the evolution of ionized hydrogen within the intergalactic medium. Using the 21 cm power spectrum evolution, we investigate the likelihood of observationally distinguishing between a constant fesc and other models that depend upon different forms of galaxy feedback. We find that changing the underlying connection between fesc and galaxy feedback drastically alters the large-scale 21 cm power. The upcoming Square Kilometre Array Low Frequency instrument possesses the sensitivity to differentiate between our models at a fixed optical depth, requiring only 200 h of integration time focused on redshifts z = 7.5–8.5. Generalizing these results to account for a varying optical depth will require multiple 800 h observations spanning redshifts z = 7–10. This presents an exciting opportunity to observationally constrain one of the most elusive parameters during the Epoch of Reionization.
Structural basis of specific DNA binding by the transcription factor ZBTB24
Authors: Ren Ren , Hardikar Swanand , Horton John R , Lu Yue , Zeng Yang , Singh Anup K , Lin Kevin , Coletta Luis Della , Shen Jianjun , Lin Kong Celine Shuet , Hashimoto Hideharu , Zhang Xing , Chen Taiping , Cheng Xiaodong 
Published: June 2019

Abstract
ZBTB24, encoding a protein of the ZBTB family of transcriptional regulators, is one of four known genes—the other three being DNMT3B, CDCA7 and HELLS—that are mutated in immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome, a genetic disorder characterized by DNA hypomethylation and antibody deficiency. The molecular mechanisms by which ZBTB24 regulates gene expression and the biological functions of ZBTB24 are poorly understood. Here, we identified a 12-bp consensus sequence [CT(G/T)CCAGGACCT] occupied by ZBTB24 in the mouse genome. The sequence is present at multiple loci, including the Cdca7 promoter region, and ZBTB24 binding is mostly associated with gene activation. Crystallography and DNA-binding data revealed that the last four of the eight zinc fingers (ZFs) (i.e. ZF5-8) in ZBTB24 confer specificity of DNA binding. Two ICF missense mutations have been identified in the ZBTB24 ZF domain, which alter zinc-binding cysteine residues. We demonstrated that the corresponding C382Y and C407G mutations in mouse ZBTB24 abolish specific DNA binding and fail to induce Cdca7 expression. Our analyses indicate and suggest a structural basis for the sequence specific recognition by a transcription factor centrally important for the pathogenesis of ICF syndrome.
Anticipated Effects of Nicotine Reduction on Youth Smoking Initiation and Maintenance
Authors: Colby Suzanne M , Cassidy Rachel N , Denlinger-Apte Rachel , Smith Tracy T , Pacek Lauren R , McClernon F Joseph , Tidey Jennifer W 
Published: June 2019

Abstract
This commentary summarizes emerging findings on the potential impact of a nicotine reduction policy on youth and young adults. We conclude that: (1) adolescent smokers and nonsmokers alike are likely to be less sensitive to reinforcement from very low nicotine content (VLNC) cigarettes compared with adults; (2) reducing nicotine in cigarettes to 0.4 mg/g would reduce the abuse potential of cigarettes in adolescents and young adults; (3) findings to date do not support concerns that nicotine reduction leads to compensatory smoking in young smokers; and (4) if the scope of a reduced nicotine product standard were applied to all combusted tobacco products, that would likely maximize public health benefit of this policy.
Temporal and spectral X-ray properties of magnetar SGR 1900+14 derived from observations with NuSTAR and XMM-Newton
Authors: Tamba Tsubasa , Bamba Aya , Odaka Hirokazu , Enoto Teruaki 
Published: June 2019

Abstract
X-ray observations play a crucial role in understanding the emission mechanism and relevant physical phenomena of magnetars. We report on X-ray observations made in 2016 of a young magnetar, SGR 1900+14, which is famous for a giant flare in 1998 August. Simultaneous observations were conducted with XMM-Newton and NuSTAR on 2016 October 20 with 23 and 123 ks exposures, respectively. The NuSTAR hard X-ray coverage enabled us to detect the source up to 70 keV. The 1–10 keV and 15–60 keV fluxes were $3.11(3)\times 10^{-12} \, {\rm erg \, s^{-1} \, cm^{-2}}$ and $6.8(3)\times 10^{-12} \, {\rm erg \, s^{-1} \, cm^{-2}}$, respectively. The 1–70 keV spectra were fitted well by a blackbody plus power-law model with a surface temperature of $kT=0.52(2) \, {\rm keV}$, a photon index of the hard power-law of Γ = 1.21(6), and a column density of $N_{\,\rm H}=1.96(11)\times 10^{22} \, {\rm cm^{-2}}$. Compared with previous observations with Suzaku in 2006 and 2009, the 1–10 keV flux showed a decrease by 25%–40%, while the spectral shape did not show any significant change with differences of kT and NH being within 10% of each other. Through timing analysis, we found that the rotation period of SGR 1900+14 on 2016 October 20 was $5.22669(3) \, {\rm s}$. The long-term evolution of the rotation period shows a monotonic decrease in the spin-down rate $\dot{P}$ lasting for more than 15 yr. We also found characteristic behavior of the hard-tail power-law component of SGR 1900+14. The energy-dependent pulse profiles vary in morphology with a boundary of 10 keV. The phase-resolved spectra show the differences between photon indices (Γ = 1.02–1.44) as a function of the pulse phase. Furthermore, the photon index is positively correlated with the X-ray flux of the hard power-law component, which could not be resolved by the previous hard X-ray observations.