bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a physical activity and nutritional intervention in overweight and obese children through an educational and recreational camp
Authors: Rauber Suliane Beatriz , Castro Henrique de Oliveira , Marinho Alcyane , Vicente Joyce Bomfim , Ribeiro Henrique Lima , Monteiro Luciana Zaranza , Praça Isabella Reis , Simoes Herbert Gustavo , Campbell Carmen Silvia Grubert 
Published: June 2018

Background: Educational camps have hosted millions of children around the world. However, few studies have described their benefits on weight control and health promotion for overweight and obese children. Aim: To investigate the impact of a health educational program for children composed of 5 days of camp and a 12-week follow up on the physical activity level, sedentary behaviour, anthropometric data and food intake in overweight and obese children. Methods: 12 children attended the Health Educational Program for Children divided into two phases. Phase 1 consisted of pre-assessments and Phase 2 corresponded to 12 weeks of follow up. Physical activity level, sedentary behaviour and food intake were assessed throughout the questionnaire. Results: After the follow up, 25% of the children became active (>1500 and <3000 Metabolic Equivalent of Tasks per week). In contrast, the number of sedentary children (<600 Metabolic Equivalent of Tasks per week) decreased by 15% and insufficiently active (600–1500 Metabolic Equivalent of Tasks per week) increased by 15%. The physical activity level of leisure time increased significantly throughout weekdays (26.0%) and weekends (14.1%) after the follow up compared to before the camp. Sedentary behaviour showed a significant reduction of 177.14 and 41.43 minutes on weekdays and weekends, respectively. Before the camp, the consumption of sugar and sweets was out of control (100% inadequate), and after the intervention, 58.4% started to consume these foods in a balanced way. Conclusions: The Health Educational Program for Children (5-day camp and the 12 weeks of follow up) contributed to an increase in the physical activity level and a reduction in the sedentary behaviour and anthropometric measures in overweight and obese children.
Using parental questionnaires to investigate the heritage language proficiency of bilingual children
Authors: Abbot-Smith Kirsten , Morawska-Patera Patrycja , Łuniewska Magdalena , Spruce Megan , Haman Ewa 
Published: June 2018

We asked whether parental questionnaires on the heritage language proficiency of bilingual children might elucidate how proficient bilingual children are in their heritage language. We tested 20 UK-based Polish–English bilingual children between 4;5 and 5;9 years on Polish and English versions of the Cross-linguistic Lexical Tasks (CLTs). These comprise receptive and expressive picture tasks. Our bilingual group performed significantly worse on the Polish CLTs than on the English CLTs overall. They also performed significantly worse on the English CLTs than did an age- and gender-matched group of monolingual English-speaking children. Therefore our bilingual sample represent the type of bilinguals for whom education professionals have difficulty determining whether weak English is due to diminished English input vs. an underlying speech, language or communication need. Parents of the bilinguals completed a Polish adaptation of the Children’s Communication Checklist 2. They also completed the Parents of Bilingual Children Questionnaire (PaBiQ), which includes risk factor measures (‘No Risk Index’ and children’s ‘Current Language Skills’). The PaBiQ also includes measures of the Amount and Length of Exposure to the majority language (English) prior to age four as well as the Proportion of English in the current input. For the bilingual sample the CCC2 General Communication Composite (GCC), which measures structural language, significantly predicted Polish CLT production, uniquely accounting for 25% of the variance. The parent-rated PaBiQ ‘Current Polish Skills’ section predicted the Polish CLT comprehension. While the PaBiQ measure of Amount and Length of English Exposure was related to both Polish comprehension and production, it did not retain significance in a regression analysis. Therefore, parental questionnaires of the heritage language could provide a useful first step for education professionals when deciding whether to refer bilingual children for speech and language assessment. Large scale studies are needed to further develop these parental questionnaires.
Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients
Authors: Zhong Ni , Zhang Youyang , Pu Xiangling , Xu Bei , Xu Mingxin , Cai Haidong , Zhang Ge , Cui Ran , Sheng Hui , Qu Shen 
Published: June 2018

Objective: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. Methods: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg). Bone mineral density of the lumbar spine, hip and femoral neck was evaluated by dual-energy X-ray absorptiometry. Fundus oculi photography for diabetic retinopathy and 24-h urine protein for diabetic nephropathy were used as markers of microangiopathy in type 2 diabetes mellitus. Characteristics of the patients and bone mineral density were compared. Multivariate analysis was used to study the association between bone mineral density and microangiopathy. Statistical analysis was performed using SPSS 20.0. p < 0.05 was considered statistically significant. Results: Group III had the lowest bone mineral density level in both genders. Multivariate analysis revealed that microangiopathy was negatively correlated with bone mineral density in females (lumbar: r = –0.522, p < 0.001; hip: r = –0.301, p = 0.010; femoral neck: r = –0.314, p = 0.009), but not in males, after adjustment for age, body mass index, hypertension, hyperlipidemia, diabetic status, hepatic function, kidney function, sex hormones and 25(OH) vitamin D. Conclusion: These results demonstrate an independent negative correlation between microangiopathy and bone mineral density in postmenopausal female type 2 diabetes mellitus patients.
Stereotactic Body Radiotherapy Treatment for Recurrent, Previously Irradiated Head and Neck Cancer
Authors: Stanisce Luke , Koshkareva Yekaterina , Xu Qianyi , Patel Ashish , Squillante Christian , Ahmad Nadir , Rajagopalan Kumar , Kubicek Gregory J. 
Published: June 2018

Purpose: Locally recurrent, previously irradiated primary head and neck tumors have historically been associated with poor outcomes. Stereotactic body radiation therapy has emerged as a feasible and promising treatment option for tumor recurrence, particularly in nonsurgical candidates. This study aimed to assess the associated outcomes of stereotactic body radiation therapy used in this setting. Methods: Retrospective analysis of a prospectively collected database of 25 patients treated with CyberKnife for unresectable, recurrent head and neck cancer in a previously irradiated field. The primary end points evaluated were rates of survival, tumor control, and treatment-related toxicities. Results: Median survival of the study population was 7.5 months (range, 1.5-47.0 months). Median survival of the 20 (80%) patients who were treated with curative purpose was 8.3 months. One-year overall survival rate for the entire population was 32%. The respective 1-year and 2-year survival rates for the curative subcohort were 40% and 20%, respectively. Local and locoregional failure occurred in 8 (32%) and 7 (28%) patients, respectively. Low severe acute (4%) and late (6%) treatment-related toxicity rates were observed. No grade 4 or 5 toxicities were observed. Conclusion: Stereotactic body radiation therapy is a viable treatment option for patients with unresectable, recurrent head and neck cancer. Significant tumor control rates are achievable with minimal severe toxicity. Although perhaps associated with patient selection and a heterogeneous sample, overall survival of stereotactic body radiation therapy outcomes appears unfavorable.
The Role of Hospital Design in Reducing Anxiety for Pediatric Patients
Authors: Cartland Jenifer , Ruch-Ross Holly S. , Carr Lauren , Hall Audrey , Olsen Richard , Rosendale Ellen , Ruohonen Susan 
Published: June 2018

Objectives: To study the impact of hospital design on patient and family experiences during and after hospitalization. Background: Hospitalization can be psychologically traumatic for children. Few research studies have studied the role of the design of the hospital environment in mitigating that traumatic experience. Methods: The study employs a two-group posttest and follow-up design to compare the impact of hospitalization on child anxiety and parent stress. It compares the experiences of children (ages 3–17) hospitalized at a new facility designed to support child-centered care and with family-friendly features with an older facility that did not have these features. The new facility was a replacement of the old one, so that many challenges to comparison are addressed. Results: Controlling for the facts of hospitalization, patient demographics, and the child’s typical anxiety level, children in the new facility experienced less anxiety than in the old facility. The study does not provide evidence that the hospital design reduced the psychological sequelae of hospitalization. Parents and children found different features of the hospital to be restorative. Conclusions: The study supports the use of Ulrich’s theory of supportive design to children’s healthcare environments, though what is experienced as supportive design will vary by the developmental stage of the child.
A fresh look at radial shaft fracture fixation: The lateral approach to the radius
Authors: Haseeb Muhammad , Muzafar Khalid , Ghani Abdul , Bhat Khurshid A , Butt M Farooq 
Published: June 2018

Introduction: Open reduction and internal fixation using plates is the gold standard for the treatment of displaced forearm bone fractures in adults. The ulna being subcutaneous throughout has a constant approach. However, the radius is approached from either the dorsal or the volar side. Both the dorsal and the volar approaches to the radial shaft involve meticulous dissection and preservation of important neurovascular structures. The posterior interosseus nerve is at risk in the dorsal approach and the radial artery and its branches in the volar approach. Dissection of these structures also adds to the operative time. The possibility of a third alternate approach was perceived, which could decrease the potential risks of the conventional approaches. Patients and Methods: Sixteen patients with radial shaft fractures in the middle third were operated on using the lateral approach: 6 of them had isolated radius fracture and 10 had both-bone fractures. There were 13 males and three females with a mean age of 37.9 years. Limited contact dynamic compression plate or locking compression plate of 3.5 mm was used to fix all fractures. All patients were operated on within 36 h of injury and then followed up till union. Union was assessed using serial radiographs and functional outcome using Anderson et al.’s criteria. The final functional outcome was assessed at an average 6 months after surgery and the results compiled. Results: The mean operative time in isolated radius fractures was 37.5 min and that for plating of both bones was 80.7 min. Primary bone grafting of the radius was done in one case and secondary bone grafting in another patient with delayed union of the radius. Union was achieved in all cases at a mean time of 17.25 weeks. The functional outcome was excellent in 10 patients, satisfactory in 5 patients, and unsatisfactory in 1 patient. Conclusion: The lateral approach is a simple approach with low operative complexity and complications. We found this approach to provide a reliably good exposure of the middle third of the radius, enabling lateral plating without complications.
Differential Misclassification of Disease under Partial-Mouth Sampling
Authors: Preisser J.S. , Sanders A.E. , Lyles R.H. 
Published: June 2018

Aim: The effect of misclassification of a cluster-level dichotomous outcome (disease) due to partial-cluster sampling on its association with a dichotomous exposure is investigated. Methods: Disease (e.g., chronic periodontitis) is deemed to exist in a cluster (e.g., full mouth) when a condition of interest (e.g., pocket depth or clinical attachment loss exceeding an established threshold) is present in number and pattern across observations (e.g., tooth sites) in the cluster according to a specific criterion. When a subset of observations within each cluster is selected (i.e., partial-mouth sampling), specificity of disease is 100% (in the absence of site-level measurement error), whereas sensitivity is imperfect and generally unknown. Using conditional probability arguments, we investigate disease misclassification under partial-cluster sampling and its impact on the estimated disease-exposure association when the exposure is cluster level and measured without error. Results: When the probability of disease varies by exposure status, outcome misclassification at the cluster level is differential under partial-cluster sampling and depends on 1) the partial recording protocol, including the number of observations sampled and the particular sites selected in a cluster; 2) the joint probability structure of the condition within clusters; and 3) the criterion for disease. A numeric example demonstrates that disease-exposure odds ratios under partial-cluster random sampling can be biased in either direction (toward or away from the null) relative to gold-standard odds ratios under full-cluster sampling. Conclusions: In general, misclassification of disease is differential under partial-cluster sampling. In particular, sensitivity and negative predictive values depend on exposure status, which leads to biased inference. Knowledge Transfer Statement: Partial-mouth sampling causes disease misclassification probabilities, including sensitivity, to vary by exposure groups when disease prevalence differs between groups. As a result, disease-exposure associations may be under- or overestimated by standard analysis procedures for periodontal data relative to full-mouth estimates. Procedures that address bias are needed for partial-recording protocols.
Psychosocial challenges and health-related quality of life of adolescents and young adults with hematologic malignancies
Authors: Husson Olga , Huijgens Peter C. , van der Graaf Winette T. A. 
Published: June 2018

Abstract
Adolescents and young adults (AYAs) occupy a unique place within the hematologic malignancy community due to the challenges they face related to their disease biology and physical, psychosocial, and economic circumstances, as well as issues related to access to care and long-term follow-up. Efforts to define age-specific (supportive) care needs and targets for intervention in these areas are evolving. This review discusses the psychosocial issues AYAs with hematologic malignancies are dealing with, how these might affect their health-related quality of life, and the challenges in delivering high-quality supportive care to this underserved population.
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL
Authors: Rossi John , Paczkowski Patrick , Shen Yueh-Wei , Morse Kevin , Flynn Brianna , Kaiser Alaina , Ng Colin , Gallatin Kyle , Cain Tom , Fan Rong , Mackay Sean , Heath James R. , Rosenberg Steven A. , Kochenderfer James N. , Zhou Jing , Bot Adrian 
Published: June 2018

Key Points
The PSI of manufactured CAR T cells was associated with clinical response and toxicities. Monitoring CAR T-cell polyfunctionality as a key product attribute may complement other characteristics including T-cell proliferation.
Management of aggressive B-cell NHLs in the AYA population: an adult vs pediatric perspective
Authors: Dunleavy Kieron , Gross Thomas G. 
Published: June 2018

Abstract
The adolescents and young adult (AYA) population represent a group wherein mature B-cell lymphomas constitute a significant proportion of the overall malignancies that occur. Among these are aggressive B-cell non-Hodgkin lymphomas (NHLs), which are predominantly diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, and Burkitt lymphoma. For the most part, there is remarkable divide in how pediatric/adolescent patients (under the age of 18 years) with lymphoma are treated vs their young adult counterparts, and molecular data are lacking, especially in pediatric and AYA series. The outcome for AYA patients with cancers has historically been inferior to that of children or older adults, highlighting the necessity to focus on this population. This review discusses the pediatric vs adult perspective in terms of how these diseases are understood and approached and emphasizes the importance of collaborative efforts in both developing consensus for treatment of this population and planning future research endeavors.
l-Glutamine for sickle cell anemia: more questions than answers
Authors: Quinn Charles T. 
Published: June 2018

Abstract
In 2017, the Food and Drug Administration approved 2 medications for sickle cell anemia (SCA): hydroxyurea for children and l-glutamine for children and adults. The approval of hydroxyurea was long overdue, but the approval of l-glutamine was a surprise to many. Any effective new treatment for SCA is a welcome advance, but there are few published studies of l-glutamine as a specific treatment for SCA. Accordingly, there are many unanswered questions about its efficacy, safety, and role in current therapy.
Rationale and design of study of dapagliflozin versus sitagliptin treatment efficacy on prevention of cardiovascular risk factors in type 2 diabetes patients: the DIVERSITY-CVR study
Authors: Shigiyama Fumika , Kumashiro Naoki , Fuchigami Ayako , Hirose Takahisa 
Published: June 2018

Abstract
Background
Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) compared to placebo in contrast to no reduction with dipeptidyl peptidase 4 (DPP4) inhibitors. However, there are no comparative studies on the effects of SGLT2 inhibitors and DPP4 inhibitors on HbA1c, body weight and hypoglycemia as risk factors of cardiovascular diseases. The aim of the present ongoing study is to compare the effects of dapagliflozin, a SGLT2 inhibitor, with those of sitagliptin, a DPP4 inhibitor, on cardiovascular risk factors in T2DM patients with inadequate glycemic control.

Methods
The study of dapagliflozin versus sitagliptin treatment efficacy on prevention of cardiovascular risk factors in T2DM patients (DIVERSITY-CVR study) is a prospective, randomized, open-label, blinded-endpoint, parallel-group, comparative study. A total of 340 T2DM patients treated with metformin alone or with no glucose-lowering agents (hemoglobin A1c ≥ 7.0 and < 10.0%) will be randomized into the dapagliflozin group (5–10 mg/day, n = 170) and the sitagliptin group (50–100 mg/day, n = 170), and treated for 24 weeks. The primary endpoint is the rate of achieving a composite endpoint of the following three items at 24th week; (1) HbA1c < 7.0%; (2) body weight loss of ≥ 3.0% from baseline; (3) avoidance of hypoglycemia. Hypoglycemia will be monitored using the flash glucose monitoring system. The secondary outcomes include each component of the primary endpoint, plus indices of lipid metabolism, and evaluations related to safety.

Conclusions
There is lack of solid information on differences in the therapeutic effects of SGLT2 inhibitors and DPP4 inhibitors on multiple risk factors for cardiovascular diseases. It is anticipated that the results of the DIVERSITY-CVR study provides useful clinical data on the management of patients with T2DM, including reducing the risk of CVD. The results of this study will become available in 2019.
Trial registration University Hospital Medical Information Network Clinical Trial Registry (UMIN000028014). Registered 30 June 2017
Just like a woman? New comparative evidence on the gender income gap across Eastern Europe and Central Asia
Authors: Blunch Niels-Hugo 
Published: June 2018

AbstractI examine the incidence and determinants of the gender income gap in Kazakhstan, Macedonia, Moldova, Serbia, Tajikistan, and Ukraine using recent household data based on an identical survey instrument across countries. Four main results are established, using a range of estimators, including OLS, interval regression, and quantile regression: (1) the presence of a substantively large gender income gap (favoring males) in all six countries; (2) some evidence of a gender-related glass ceiling in some of these countries; (3) some evidence that endowments diminish the income gaps, while the returns to characteristics increase the gaps; and (4) while observed individual characteristics explain a part of the gaps, a substantial part of the income gap is left unexplained. In sum, these results are consistent with the presence of income discrimination towards females but at the same time also point towards the importance of continued attention towards institutions and economic policy for decreasing the gender income gap in these former formally gender neutral economies—notably through attention towards the maternity and paternity leave system, as well as public provision of child care.JEL Classification:J16, J31, J7
Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis
Authors: Scott Jessica M. , Zabor Emily C. , Schwitzer Emily , Koelwyn Graeme J. , Adams Scott C. , Nilsen Tormod S. , Moskowitz Chaya S. , Matsoukas Konstantina , Iyengar Neil M. , Dang Chau T. , Jones Lee W. 
Published: June 2018

Purpose To evaluate the effects of exercise therapy on cardiorespiratory fitness (CRF) in randomized controlled trials (RCTs) among patients with adult-onset cancer. Secondary objectives were to evaluate treatment effect modifiers, safety, and fidelity. Methods A systematic search of PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library was conducted to identify RCTs that compared exercise therapy to a nonexercise control group. The primary end point was change in CRF as evaluated by peak oxygen consumption (VO2peak; in mL O2 × kg−1 × min−1) from baseline to postintervention. Subgroup analyses evaluated whether treatment effects differed as a function of exercise prescription (ie, modality, schedule, length, supervision), study characteristics (ie, intervention timing, primary cancer site), and publication year. Safety was defined as report of any adverse event (AE); fidelity was evaluated by rates of attendance, adherence, and loss to follow-up. Results Forty-eight unique RCTs that represented 3,632 patients (mean standard deviation age, 55 ± 7.5 years; 68% women); 1,990 (55%) and 1,642 (45%) allocated to exercise therapy and control/usual care groups, respectively, were evaluated. Exercise therapy was associated with a significant increase in CRF (+2.80 mL O2 × kg−1 × min−1) compared with no change (+0.02 mL O2 × kg−1 × min−1) in the control group (weighted mean differences, +2.13 mL O2 × kg−1 × min−1; 95% CI, 1.58 to 2.67; I2, 20.6; P < .001). No statistical significant differences were observed on the basis of any treatment effect modifiers. Thirty trials (63%) monitored AEs; a total of 44 AEs were reported. The mean standard deviation loss to follow-up, attendance, and adherence rates were 11% ± 13%, 84% ± 12%, and 88% ± 32%, respectively. Conclusion Exercise therapy is an effective adjunctive therapy to improve CRF in patients with cancer. Our findings support the recommendation of exercise therapy for patients with adult-onset cancer.