bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: Protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma
Authors: Murchie Peter , Masthoff J , Walter FM , Rahman K , Allan JL , Burrows N , Proby C , Lee AJ , Johnston M , Durrani A , Depasquale I , Brant B , Neilson A , Meredith F , Treweek S , Hall S , McDonald A 
Published: January 2019

Abstract
Background: Melanoma is common, 15,906 people in the UK were diagnosed with melanoma in 2015 and incidence has increased five-fold in 30 years. Melanoma affects old and young people with poor prognosis once metastatic. UK guidelines recommends people treated for cutaneous melanoma receive extended outpatient hospital follow-up to detect recurrence or new primaries. Such follow-up to the growing population of melanoma survivors is burdensome for both individuals and health services. Follow-up is important since approximately 20% of patients with early-stage melanoma experience a recurrence and 4-8% develop a new primary, the risk of both is highest in the first five years. ASICA (Achieving Self-directed Integrated Cancer Aftercare) is a digital intervention to increase Total-Skin-Self-Examination (TSSE) by people treated for melanoma, with usual follow-up.
Methods: We aim to recruit 240 adults with a previous first stage 0-2C primary cutaneous melanoma from secondary care in North-East Scotland and the East of England. Participants will be randomised to receive the ASICA intervention (a tablet based digital intervention to prompt and support TSSE) or control group (treatment as usual). Patient-reported and clinical data will be collected at baseline, including the modified Melanoma Worry Scale (MWS), the Hospital Anxiety and Depression Scale (HADs), the EuroQoL EQ-5D-5L, and questions about TSSE practice, intentions, self-efficacy and planning. Participants will be followed up by postal questionnaire at 3, 6 and 12 months following randomisation along with a 12 month review of clinical data. 12 months following randomisation will be considered the primary timepoint for outcome analyses.
Discussion: If the ASICA intervention improves total-skin-self-examination practice in those affected by melanoma, this may lead to improved psychological well-being and earlier detection of recurrent and new primary melanoma. This could impact both patients and NHS resources. This study will determine if a full scale randomised controlled trial can be undertaken in the UK NHS to provide the high-quality evidence needed determine the effectiveness ASICA is a pilot study evaluating the effectiveness of total skin self-examination practice in those affected by melanoma.
Trial Registration: Clinical Trials.gov :Trial registration number NCT03328247. Registered 01 November 2017, https://clinicaltrials.gov/ct2/show/NCT03328247?term=ASICA&rank=1. First participant randomised on 25 January 2018.
Keywords: Primary care, Melanoma, Cancer, Randomised Controlled Trial, Survivorship, Self-directed care, e-health, ASICA.
The multi-objective operation for cascade reservoirs using MMOSFLA with emphasis on power generation and ecological benefit
Authors: Yang Zhe , Yang Kan , Su Lyuwen , Hu Hu 
Published: January 2019

Abstract
To efficiently develop power generation and solve downstream ecological health protection in Qingjiang basin, multi-objective ecological operation for cascade reservoirs (MOEOCR) model is established in contrast to conventional models that set ecological water requirement as constraint. The basic, suitable and ideal ecological water requirements in Geheyan and Gaobazhou sections are calculated using a requirement level index. Instead of the traditional evolution mode based on population, we introduce a shuffled frog leaping algorithm (SFLA) which evolves independently in sub-populations. Moreover, the SFLA is converted into a modified multi-objective algorithm (MMOSFLA) with strategies including chaotic population initialization, renewed frog grouping method and local search method, and elite frog set evolution based on cloud model. The water level corridor is used to help effectively handle complex constraints. The IGD and GD indexes are used to evaluate quality of solutions acquired by each method. In terms of normal year, the mean IGD and GD of MMOSFLA are 1.2 × 10–1 and 2.75 × 10–2, respectively. The scheduling results verify efficient search ability and convergence performance in solution diversity and distribution in comparison with other methods. Therefore, MMOSFLA is verified to provide an effective way to fulfill hydropower and ecological benefits facing the MOEOCR problem.
Inactivation of health-related microorganisms in water using UV light-emitting diodes
Authors: Oguma Kumiko , Rattanakul Surapong , Masaike Mie 
Published: January 2019

Abstract
UV light-emitting diodes (UV-LEDs) offer various wavelength options, while microorganisms have spectral sensitivity, or so-called action spectra, which can be different among species. Accordingly, matching properly the emission spectra of UV-LEDs and the spectral sensitivity of microorganisms is a reasonable strategy to enhance inactivation. In this study, UV-LEDs with nominal peak emissions at 265, 280 and 300 nm were applied to pathogens including Legionella pneumophila, Pseudomonas aeruginosa, Vibrio parahaemolyticus and feline calicivirus, in comparison with indicator species including Escherichia coli, Bacillus subtilis spores, bacteriophage Qβ and MS2. The results indicated that, for all species tested, 265 nm UV-LED was highest in the fluence-based inactivation rate constant k, followed by 280 nm and 300 nm was much lower. The k value at 280 nm was close to that at 265 nm for feline calicivirus and MS2, suggesting that 280 nm UV-LED can be as good an option as 265 nm UV-LED to inactivate these viruses. Bacteria tended to show fluence-response curves with shoulder and tailing, while viruses followed log-linear profiles at all wavelengths tested. This study indicates the fluence-response profiles and the fluence required for a target inactivation of microorganisms, which would serve as reference data for future study and applications of UV-LEDs.
Can participatory water management improve residents' subjective life quality? A case study from China
Authors: Pan Hulin , Guo Min 
Published: January 2019

Abstract
Public participation is practiced widely in modern water management, but its effect on residents' subjective quality of life (QOL) or happiness has not been revealed. In this research, using the difference-in-difference (DID) model, the effect of participation in water management on residents' subjective QOL or happiness is empirically researched based on data from China. The results show that the positive effect of participatory water management on residents' happiness is quite significant and the extra effect of participation behavior on the participant's happiness is outstanding with the coefficients 0.073 and 0.036 respectively which pass the significance test. In addition, according to the regression coefficients of controlled variables, four demographic variables, namely the age, health, education and income, also produce significant effects on residents' happiness. It is concluded that both the result and procedure of participatory water management can really improve the participants' happiness. Extensive participation should be enhanced actively so as to increase residents' happiness.
The role of reclaimed water for crop irrigation in southeast Spain
Authors: Maestre-Valero J. F. , González-Ortega M. J. , Martínez-Álvarez V. , Martin-Gorriz B. 
Published: January 2019

AbstractWater shortages have led to measures such as the implementation of reclaimed water (RW) for irrigation in order to sustain agriculture. Waste water requires treatment to become a safe water resource for irrigation. This paper presents an analytical study on the use of RW for irrigation in the southeast of Spain, identifying its strengths and current limitations. It includes official data from 13 waste water treatment plants (WWTPs) belonging to two coastal irrigation districts in the Region of Murcia. The content of essential nutrients in some RWs might allow them to supply a large fraction of the fertilizers required by the crops, thus saving energy and reducing the cost of fertilization. However, the accumulation of chloride, sodium, and boron could damage soils and cause phytotoxicity to crops in the mid-term, reducing yields. Microbiological pollutants in the RW could also endanger human health and hence waste water treatment is required. In the selected WWTPs, all effluents met the minimum requirements established in Water Quality 2.3 by the Royal Decree 1620/2007 and also with the European Classes B and C proposed by COM[2018] 337. Blending RW and other water resources of better quality is recommended for the sustainable use of RW for irrigation.
Enhanced adsorption of nitrate from water by modified wheat straw: equilibrium, kinetic and thermodynamic studies
Authors: Mehdinejadiani Behrouz , Amininasab Seyed Mojtaba , Manhooei Leila 
Published: January 2019

Abstract
This study represents the first attempt to chemically modify wheat straw (WS) using 3-chloropropyltrimethoxysilane (CPTMS) and (1,4-diazabicyclo[2.2.2]octane) (DABCO). Field emission scanning electron micrographs (FESEM), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA) and Fourier transform infrared (FTIR) spectra confirmed the successful morphological and structural modification of WS and the thermal stability of the modified WS (MWS). The MWS was used to remove nitrate from water. The optimum conditions of nitrate adsorption onto MWS were examined by conducting batch experiments. The results indicated that 85% of nitrate was removed under the conditions of initial nitrate concentration = 20 mg L−1, initial solution pH = 7, contact time = 10 min, MWS dosage = 2 g L−1 and temperature ≈ 25 °C. The kinetic adsorption data were best fitted to the general order model and the adsorption process occurred in three distinct stages. The equilibrium adsorption data were well described by the Langmuir isotherm. Additionally, separation factor values were smaller than 1, implying that the adsorption process was favorable. The presence of competing anions impeded the nitrate adsorption in the order of sulfate &gt; chloride &gt; bicarbonate&gt; phosphate. Thermodynamic parameters suggested that the adsorption process was exothermic, feasible and spontaneous in nature. Overall, the MWS could achieve efficient removal of nitrate under the simplest operating conditions.
A study by response surface methodology (RSM) on optimization of phosphorus adsorption with nano spherical calcium carbonate derived from waste
Authors: Deng Shuo , Chen Yinguang 
Published: January 2019

Abstract
A nano spherical CaCO3 (NSC) derived from solid waste (precipitated from tris(α-chloropropyl) phosphate and triethyl phosphate mixed wastewater) was prepared as adsorbent for phosphorus removal from aqueous solution. Response surface methodology (RSM) was used to develop an approach for the evaluation of phosphorus adsorption process, and Box-Behnken design was performed to investigate the effects of various experimental parameters (temperature, contact time, initial pH and dosage of absorbent) on phosphorus adsorption. The model results of experimental data gave a high correlation coefficient (R2 = 0.9658), and a predictive model of quadratic polynomial regression equation and optimum level values were established successfully. It was found that the adsorption efficiency and adsorption capacity reached 97.05% and 123.79 mg/g, respectively, under conditions of temperature of 45 °C, initial pH 5.3, contact time of 11 h, and absorbent amount of 392 mg/L. X-ray diffraction (XRD) analysis testified new phase, Ca10(PO4)6CO3, was produced in the adsorption process. Apart from that, adsorption behavior fitted well with the Langmuir isotherm model and logistic growth model. The thermodynamic study indicated that phosphorus removal by NSC as adsorbent was a spontaneous, endothermic, and mainly chemical adsorption process.
Preparation of a novel Cu-Sn-Bi cathode and performance on nitrate electroreduction
Authors: Gao Weichun , Gao Lulu , Meng Jing , Li Dan , Guan Yinyan , Cui Li , Shen Xinjun , Liang Jiyan 
Published: January 2019

Abstract
Cu-Sn-Bi layer coated on Ti substrate was prepared using electrodeposition method and applied as cathode material for electrochemical reduction of nitrate in this research. Linear sweep voltammetry (LSV), chronoamperometry (CA), scanning electron microscope (SEM), energy dispersive spectrometry (EDS), X-ray diffraction (XRD) were used to scrutinize the electrochemical performance and the cathode materials. LSV results illustrated that Cu-Sn-Bi cathode possessed the ability for nitrate reduction. Preparation conditions including deposition time, current density, temperature and the content of Bi were optimized based on NO3–N removal and byproducts selectivity. Results showed that the cathode with Bi content of 3.18 at.%, and electrodepositing at current density of 6 mA cm−2, 35 °C for 30 min achieved the best performance during the experiment. The increase of Bi content could improve the electrocatalytic activity and stability of the cathode. Compared with other common researched cathodes (Cu and Fe), Cu-Sn-Bi (3.18 at.%) exhibited better performance, i.e. the highest NO3–N removal of 88.43% and the selectivity of harmless N2 was 77.80%. The kinetic studies showed that the reduction of nitrate on Cu-Sn-Bi followed pseudo-first-order kinetics.
Computational Method for the Identification of Molecular Metabolites Involved in Cereal Hull Color Variations
Authors: Zhang Yunhua , Dong Dong , Li Dai , Lu Lin , Li JiaRui , Zhang YuHang , Chen Lijuan 
Published: January 2019

Background:
Cereal hull color is an important quality specification characteristic. Many
studies were conducted to identify genetic changes underlying cereal hull color diversity. However,
these studies mainly focused on the gene level. Recent studies have suggested that metabolomics can
accurately reflect the integrated and real-time cell processes that contribute to the formation of
different cereal colors.

Methods:
In this study, we exploited published metabolomics databases and applied several
advanced computational methods, such as minimum redundancy maximum relevance (mRMR),
incremental forward search (IFS), random forest (RF) to investigate cereal hull color at the metabolic
level. First, the mRMR was applied to analyze cereal hull samples represented by metabolite
features, yielding a feature list. Then, the IFS and RF were used to test several feature sets,
constructed according to the aforementioned feature list. Finally, the optimal feature sets and RF
classifier were accessed based on the testing results.

Results and Conclusion:
A total of 158 key metabolites were found to be useful in distinguishing
white cereal hulls from colorful cereal hulls. A prediction model constructed with these metabolites
and a random forest algorithm generated a high Matthews coefficient correlation value of 0.701.
Furthermore, 24 of these metabolites were previously found to be relevant to cereal color. Our study
can provide new insights into the molecular basis of cereal hull color formation.
Constructing a Risk Prediction Model for Lung Cancer Recurrence by Using Gene Function Clustering and Machine Learning
Authors: Zhong Jing , Chen Jian-Ming , Chen Song-Lin , Yi Yun-Feng 
Published: January 2019

Objective:
A significant proportion of patients with early non-small cell lung cancer
(NSCLC) can be cured by surgery. The distant metastasis of tumors is the most common cause of
treatment failure. Precisely predicting the likelihood that a patient develops distant metastatic risk
will help identify patients who can further intervene, such as conventional adjuvant chemotherapy
or experimental drugs.

Methods:
Current molecular biology techniques enable the whole genome screening of
differentially expressed genes, and rapid development of a large number of bioinformatics methods
to improve prognosis.

Results:
The genes associated with metastasis do not necessarily play a role in the pathogenesis of
the disease, but rather reflect the activation of specific signal transduction pathways associated
with enhanced migration and invasiveness.

Conclusion:
In this study, we discovered several genes related to lung cancer resistance and
established a risk model to predict high-risk patients.
The Adverse Events Rate of Endothelial Progenitor Cell Capturing Stent in the Treatment of CAD Patients
Authors: Xu Wei-Yuan , Tang Wei-Liang , Yuan Min , Sun Yong , Xu Feng , Peng Fang 
Published: January 2019

Background:
Circulating endothelial progenitor cells (EPCs) have regenerative capacities
and play an important role in vessel wall homeostasis. When attracted to the site of vessel wall
injury, EPCs rapidly differentiate into a functional layer as part of the healing process. The Genous
TM endothelial progenitor cell (EPC) capturing stent is coated with anti-human CD34+ antibodies
which combine with circulating EPCs from the peripheral blood to the stent surface.

Objective:
This meta-analysis aims to explore the Genous TM endothelial progenitor cell capturing
stent in coronary artery disease (CAD) adverse event rate after one-year follow-up.

Methods:
PubMed, EMBASE and, Google Scholar databases were searched for eligible studies.
CAD survival data and clinicopathological features were analyzed by expected shortfall (ES) and
95% CI. Fixed-effect model and random-effect model are used for summary statistics.

Results:
12 studies, including 15985 coronary artery disease (CAD) patients who received PCI
treatment were included in this study. After 1-year follow-up, the rate of adverse event showed that
the target vessel failure (TVF) was 8.5% (7.6%-17.4%), target vessel revascularization was 4.1%
(TVR, 0-15.6%), target lesion revascularization was 4.2% (TLR, 3.7%-22%), myocardial infarction
was 2.0% (MI, 1.8%-5.2%), major adverse cardiac events was 8.7% (MACE, 6.4%-28%), and the
all-cause death was 4.0% (0-9.2).

Conclusion:
After one-year follow-up, the incidence rate of Genous stent adverse events was stable
in CAD patients. The study showed a better evaluation of Genous stent, and it provides a better
reference for CAD clinical treatment.
Line of Progression: Indian Regulatory Framework for Nutraceuticals and Dietary Supplements
Authors: Bansal Rohit , Dhiman Anju 
Published: January 2019

Introduction:Nutraceuticals although is a widely accepted term and now well understood, there exists several nomenclature and definitions across the countries. The present article discussed the progression of Indian food product regulations over the years, mainly emphasizing on regulations of nutraceuticals and dietary supplements.Regulatory Progression in India:The regulatory structure of nutraceuticals in India has evolved after the establishment of Food Safety and Standard act in 2006, which brought together preexisting eight laws to one single law regulated by Food Safety and Standard Authority of India (FSSAI). After the introduction of this act, the regulatory framework of food products progressed year by year with continuous amendments to this Act. The major milestone in the field of nutraceuticals was in 2016 with the introduction of regulations of functional food and nutraceuticals. Under these regulations, various guidelines were laid down for nutraceuticals in terms of their safety standards, health claims along with permissible limits of active ingredients and excipients for the safe and effective use.Conclusion:India has progressed in the development of a strong regulatory framework for nutraceuticals; however, to effectively implement these guidelines and for ensuring the safe and nutritious food, a robust system and a better-coordinated actions are required.
The Table to Tablet (T2T) Speech and Language Therapy Software Development Roadmap (Preprint)
Authors: Jesus Luis MT , Santos Joaquim , Martinez Joana 
Published: January 2019

BACKGROUND

Few studies have analyzed gains in using computers in speech and language therapy interventions for children with speech and/or language disorders when compared to a control group, but virtual tutors and computer-based visual feedback have been gaining interest in the literature. Previous systematic reviews mainly focused on development technological details of computer-based speech training systems or the potential of integrating mobile technology into education and rehabilitation, but recent systematic reviews have also evaluated the efficacy of computer-based speech and language therapy for children and how digital technology can support different activities, at school or elsewhere.

OBJECTIVE

This study aimed to analyze a continuous communication and joint team approach to develop solutions focused on the real needs of end users, which digitally emulate reliable and validated physical intervention materials for children with speech sound disorders (SSD).

METHODS

The Table to Tablet (T2T) software was developed using a design-based research methodology, which included four phases: activities development; ethnographic pretesting with a sample from the target population; software development; and beta-testing. The technology used to develop the software, the method used to ensure satisfaction and replay ability of the intervention materials, and results from the ethnographic and beta-testing phases are presented.

RESULTS

Nineteen activities were developed during the first phase, which were then tested, with 7 service users, using a physical prototype. The beta-test approach included extensive testing and reformulation, supported by direct, nonparticipant observation and data collection using a questionnaire designed for children. Feedback was used to improve the software and interaction with users.

CONCLUSIONS

The use of T2T-based intervention programmes by speech and language therapists (SLTs) will allow these professionals to make a better and more effective communication intervention, based on proven methodologies, that coexists in a structured physical and a digital version. These versions provide a full, 6-week intervention program, with minimal effort in preparing the session by the SLTs while delivering a very consistent intervention, with high replay value. A continuous communication and joint team approach was beneficial to the project and to the development of a solution focused on the real needs of SLTs and children with SSD. All problems were approached as a team with different skills and expertise, which minimized errors (eg, the developer making choices that would save him from spending time doing something that would not be used) and time spent. To add to this, the importance of integrating the end users as testers and collecting their opinions and actions per session allowed the production of better-targeted activities.

CLINICALTRIAL

ClinicalTrials.gov NCT02490826; https://clinicaltrials.gov/ct2/show/NCT02490826