bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages
Authors: Ye Guozhu , Chen Guoyou , Gao Han , Lin Yi , Liao Xu , Zhang Han , Liu Xinyu , Chi Yulang , Huang Qiansheng , Zhu Huimin , Fan Yuhua , Dong Sijun 
Published: April 2019

AbstractDisordered intestinal metabolism is highly correlated with atherosclerotic diseases. Resveratrol protects against atherosclerotic diseases. Accordingly, this study aims to discover novel intestinal proatherosclerotic metabolites and potential therapeutic targets related to the anti‐atherosclerotic effects of resveratrol. An untargeted metabolomics approach was employed to discover novel intestinal metabolic disturbances during atherosclerosis and resveratrol intervention. We found that multiple intestinal metabolic pathways were significantly disturbed during atherosclerosis and responsive to resveratrol intervention. Notably, resveratrol abolished intestinal fatty acid and monoglyceride accumulation in atherosclerotic mice. Meanwhile, oleate accumulation was one of the most prominent alterations in intestinal metabolism. Moreover, resveratrol attenuated oleate‐triggered accumulation of total cholesterol, esterified cholesterol and neutral lipids in mouse RAW 264.7 macrophages by activating ABC transporter A1/G1‐mediated cholesterol efflux through PPAR (peroxisome proliferator‐activated receptor) α/γ activation. Furthermore, we confirmed that PPARα and PPARγ activation by WY14643 and pioglitazone, respectively, alleviated oleate‐induced accumulation of total cholesterol, esterified cholesterol and neutral lipids by accelerating ABC transporter A1/G1‐mediated cholesterol efflux. This study provides the first evidence that resveratrol abolishes intestinal fatty acid and monoglyceride accumulation in atherosclerotic mice, and that resveratrol suppresses oleate‐induced accumulation of total cholesterol, esterified cholesterol and neutral lipids in macrophages by activating PPARα/γ signalling.
Pinjata ruminata gen. et sp. n.—A New Member of Centrohelid Family Yogsothothidae (Haptista: Centroplasthelida) from the Brackish River
Authors: Zlatogursky Vasily V. , Gerasimova Elena A. , Drachko Daria , Klimov Vladimir I. , Shɨshkin Yegor , Plotnikov Andrey O. 
Published: April 2019

AbstractA new genus and species of centrohelid heliozoan Pinjata ruminata from the Tuzlukkol’ River (Orenburg Region of Russia) and Gorʼkoe Lake (Chelyabinsk Region of Russia) is studied with light‐ and electron microscopy. Pinjata ruminata has two types of plate scales, partially running up the sides of the axopodia. Inner plate scales (3.2–4.9 × 1.5–2.6 μm) are flat, ovate‐oblong and have a broad axial thickening and a thin electron‐dense border. Outer plate scales (4.2–6.7 × 1.5–3.0 μm) are concave, elongated, of irregular shape, often curved, and broadened towards one end. Roundish depressions are forming two rows on both sides of the narrow axial thickening. The cells are attached to the substratum. Molecular phylogenetic analysis based on the SSU rDNA robustly placed P. ruminata in the family Yogsothothidae. This position is confirmed with the presence of five panacanthocystid increase regions. The morphology of the new genus is in a good accordance with diagnosis of the family. The status of a genus “Heteroraphidiophrys” is discussed. Other potential findings of Pinjata from literature are analyzed. Pinjata represents the third lineage of centrohelids, characterized with the presence of only tangentially oriented plate scales. The halophilic nature of Yogsothothidae is suggested.
Solitary fibrous tumor arising from pelvic retroperitoneum: A report of two cases and a review of the literature
Authors: Yamada Kaori , Abiko Kaoru , Kido Aki , Minamiguchi Sachiko , Horie Akihito , Mandai Masaki 
Published: April 2019

AbstractSolitary fibrous tumors (SFT) rarely arise in the pelvis. Here, we report two cases of SFT arising from the pelvic retroperitoneum. The first case involves a 64‐year‐old woman diagnosed with a 5‐cm pelvic mass. Magnetic resonance imaging revealed a solid and cystic mass with marked enhancement, but limited water restriction. During surgery, intraligamental tumor arising near the round ligament was resected. Pathologically, the tumor comprised dilated vessels and spindle‐shaped cells positive for STAT6 and CD34. The second case involves a 53‐year‐old woman diagnosed with a 4.5‐cm pelvic mass through computed tomography. Magnetic resonance imaging demonstrated a solid mass with multiple cysts with strong enhancement and slight water restriction. During surgery, the tumor was found in the retroperitoneum. Pathologically, spindle‐shaped tumor cells positive for STAT6 and CD34 had proliferated around the prominent hyalinized vessels. Although rare in the pelvis, SFT should be suspected when a mass with strong enhancement is found.
Defining short and long sleep duration for future paediatric research: A systematic literature review
Authors: Sawyer Emily , Heussler Helen , Gunnarsson Ronny 
Published: April 2019

SummaryShort and long sleep patterns in children have been associated with a range of poor health outcomes. However, there is no consensus regarding the definitions of these abnormal sleep parameters in childhood for use in paediatric research. Given that there is a clear lack of definitions for sleep duration throughout paediatric sleep literature, this review aimed to establish recommendations for standard cut‐offs of short and long sleep for children aged 1–16 years to enable homogeneity in future studies of paediatric sleep duration. Four databases were systematically searched to identify prospective studies that defined short or long sleep patterns in children. Included papers (38) were assessed for methodological quality, and their definitions were extracted to examine the current applied cut‐offs in the literature for short or long sleep duration. The definitions were analysed in a regression model to summarize applied cut‐offs from subjective data into cut‐offs for short and long sleep duration. These models were fitted to reference values of three commonly cited paediatric population studies to establish new definitions of sleep duration for future use in research. Across the age groups there was little consensus in applied cut‐offs for short and long sleep duration. This study found the best compromise for short sleep was defined as the 2.5th centile (hours = 0.25*age + 11) and long sleep as the 97.5th centile (hours = 0.017*age2 − 0.68*age + 16) of sleep duration in children. Recommendations for the hourly cut‐offs of short and long sleep duration based on these percentiles were described.
Regional alterations in human choroidal thickness in response to short‐term monocular hemifield myopic defocus
Authors: Hoseini‐Yazdi Hosein , Vincent Stephen J , Collins Michael J , Read Scott A 
Published: April 2019

AbstractPurposeTo examine the regional changes in human choroidal thickness following short‐term exposure to hemifield myopic defocus using optical coherence tomography (OCT).MethodsThe central 26˚ visual field of the left eye of 25 healthy young adults (mean age 26 ± 5 years) was exposed to 60 min of clear vision (control session), +3 D full‐field, +3 D superior retinal and +3 D inferior retinal myopic defocus, with the right eye occluded. Choroidal thickness across the central 5 mm (17°) macular region was examined before and after 60 min of defocus using a high‐resolution, foveal centred vertical OCT line scan, with optical defocus simultaneously imposed using a Badal optometer and cold mirror system mounted on a Spectralis OCT device.ResultsAveraged across the central 5 mm macular area, choroidal thickness decreased by −4 ± 7 μm during the control session (p = 0.01), most likely due to the unique stimulus conditions of this study. The mean macular choroidal thickness increased during full‐field (+2 ± 8 μm), inferior retinal (+3 ± 7 μm) and superior retinal myopic defocus (+5 ± 9 μm), representing a significant thickening of the choroid compared to the control session (all p < 0.05). The defocus induced changes in macular choroidal thickness differed between the superior and inferior hemiretinal regions (F2.26, 54.27 = 29.75, p < 0.001). When only the superior retina was exposed to myopic defocus, the choroid thickened in the superior region (+7 ± 8 μm, p < 0.001), but did not change significantly in the inferior region (+3 ± 9 μm, p = 0.12). When only the inferior retina was exposed to myopic defocus, the choroid thickened inferiorly (+4 ± 8 μm, p = 0.005), with no significant change observed in the superior region (+1 ± 8 μm, p = 0.46).ConclusionsThese findings provide evidence supporting a local regional choroidal response to myopic defocus in the human eye, with hemifield myopic defocus leading to significant thickening of the choroid localised to the retinal region exposed to defocus. The novel finding of a localised response of the human choroid to hemifield myopic defocus, particularly in the superior hemiretina, may have important implications in optimising the optical design of myopia control interventions.
Functional limitations recognised by adults with amblyopia and strabismus in daily life: a qualitative exploration
Authors: Kumaran Sheela E , Khadka Jyoti , Baker Rod , Pesudovs Konrad 
Published: April 2019

AbstractPurposePatients’ perceptions about the functional impact of amblyopia and strabismus in daily life have not been explored extensively. Therefore, this study aimed to explore the lived experiences of adults with these conditions and understand the functional limitations they face in their day‐to‐day life.MethodsA qualitative study design was adopted. Participants over 18 years of age, with a primary diagnosis of amblyopia (with or without strabismus) were recruited from the community and various eye care practices in South Australia and Victoria, Australia. Participants took part in either focus group discussions or individual interviews and described the functional limitations they experienced in their daily life due to their eye condition. These sessions were audio recorded, transcribed verbatim, coded inductively, and analysed iteratively to form emergent themes.ResultsThirty‐seven adult participants took part in the study: 23 (62%) had strabismic amblyopia; 5 (14%) anisometropic amblyopia;, 7 (19%) combined‐mechanism amblyopia; and 2 (5%) deprivational amblyopia. Their median age was 54 years (range: 21–82 years) and 19 (51%) were female. Participants reported several challenges in performing everyday tasks such as driving (e.g. judging distances, changing lanes), reading (e.g. fine print, reading for prolonged time) and sports (e.g. catching a ball). They also articulated trouble in navigating safely (e.g. using stairs, bumping into objects), performing work‐tasks (e.g. taking longer than peers to complete tasks) and other routine tasks (e.g. chopping vegetables with care).ConclusionsSeveral functional limitations were encountered by adults living with amblyopia and strabismus. Participants recognised these limitations in their normal day‐to‐day life and related the challenges they faced to symptoms associated with their eye condition. By presenting rich in‐depth qualitative data, the paper demonstrates qualitative evidence of the functional impacts associated with amblyopia and strabismus.
Thirty day mortality after neonatal laparotomy in a Chinese tertiary hospital
Authors: Song Linlin , Gao Yangxu 
Published: April 2019

AbstractBackgroundNo data are available on the prevalence of mortality in neonates after major surgery such as laparotomy in China.MethodsIn a tertiary general hospital, 142 newborns who underwent laparotomy for a variety of surgical conditions in the past 6 years were included in this study in Beijing, China. Pre‐, intra‐, and postoperative variables potentially predictive of postoperative 30 day mortality were collected and compared between the surviving and deceased newborns.ResultsDeath ≤30 days after laparotomy occurred in 19 of 142 newborns (13.4%) during the study period. Newborns diagnosed with necrotizing enterocolitis (NEC) had the worst outcome (OR, 11.4). Significantly more neonates in the 30 day death group were intubated preoperatively (52.6%) compared with the survival group (19.5%; OR, 10.0). Base excess ≤−10 mmol/L immediately after laparotomy was associated with negative prognosis in the early postoperative period (OR, 11.2).ConclusionThe mortality rate of newborns ≤30 days after laparotomy was 13.4% in a Chinese tertiary general hospital in the past 6 years. The factors associated with early death were NEC, preoperative intubation with mechanical ventilation, and postoperative immediate base excess ≤−10 mmol/L.
Estimating the demand for reserve assets across diverse groups of countries
Authors: Bhattacharya Rina , Mann Katja , Nkusu Mwanza 
Published: April 2019

AbstractThis paper takes a fresh look at the determinants of the holding of reserves with the aim of highlighting similarities and differences among emerging markets (EMs), advanced economies (AEs), and low‐income countries (LICs). We apply two panel estimation techniques: fixed effects (FE) and common correlated effects pooled mean group (CCEPMG). FE regression results suggest that precautionary savings’ motives, both current account‐ and capital account‐related, are generally the most important determinants of reserves’ holding for all country groups. Nonetheless, there is considerable heterogeneity across country groups and over time. The intertemporal motive, a novelty of this paper, has gained importance everywhere. The CCEPMG results confirm the importance of precautionary motives and suggest that current account motives matter only for EMs and LICs and capital account motives matter for all groups while being more relevant for EMs. The CCEPMG results also point to the importance of taking into account the heterogeneous impact of unobserved common factors that affect coefficient estimates and the dynamic process through which reserves adjust to changes.
A detrital apatite fission‐track study of the CIROS‐2 sedimentary record: Tracing ice pathways in the Ross Sea area over the last 5 Ma
Authors: Li Xia , Zattin Massimiliano , Olivetti Valerio 
Published: April 2019

AbstractThe Ross Sea is a crucial area to investigate pathways of ice during the Cenozoic as it records the evolution of both the East and West Antarctic Ice Sheets. This work is based on detrital apatite fission track (AFT) data extracted from the sedimentary record of well CIROS‐2, which spans the last 5 Ma. The AFT data show a large range of ages, and most of the grains fit well with two main components that fall between 24 and 42 Ma and between 43 and 70 Ma, whereas the other components are not regularly distributed through the well, thus indicating a mixture of provenance from different areas along the Transantarctic Mountains. As a whole, our work suggests glacial expansion over the McMurdo Sound during the Pliocene, and ice periodically invading and retreating in Pleistocene.
In vitro assessment of the long‐term stability of the inhibitory effects of canine and feline plasma on MMP 2 and 9
Authors: Lively Melissa J. , Westermeyer Hans D. 
Published: April 2019

AbstractPurposeTo evaluate the effect of increasing storage time on the inhibitory effects of canine and feline plasma on matrix metalloproteinases (MMP) 2 and 9 in vitro.MethodsMatrix metalloproteinases 2 and 9 activity in the presence of canine plasma stored for 57, 155, 222, 316, 367, and 438 days, and feline plasma stored for 17, 198, 565, and 954 days was assayed using a commercially available colorimetric assay kit.ResultsFor canine plasma, the MMP 2 activity for older samples was not significantly different than the 57‐day sample (P = 0.2025‐0.9033). Two canine samples had significantly lower MMP 9 activity than the 57‐day sample (367 days: P = 0.0099, 438 days: P = 0.0348, others P = 0.0778‐0.9928). For feline plasma, storage time did not significantly affect inhibition of MMP 2 and MMP 9 activity (ANOVA, P = 0.2688 and P = 0.2404, respectively).ConclusionsIncreasing storage time does not significantly decrease the inhibiting activity of plasma on MMP 2 and 9 for up to 14 months in dogs and 31 months in cats.
The relevance of ultrasound examination of the foot and ankle in patients with rheumatoid arthritis – a review of the literature
Authors: Șerban Oana , Bădărînză Maria , Fodor Daniela 
Published: April 2019

Rheumatoid arthritis (RA) is an inflammatory disease characterized by symmetrical involvement of the joints and tendons, especially of the hands and wrists, but also of the feet and ankles from the very beginning of the disease. For the patient, the foot and ankle involvement is equally important as the other joints, since it affects the functionality of the feet and the quality of life of the patients. It is already known that subclinical involvement of the ankles and feet occurs even in patients that are considered in clinical remission, thus they do not need for changes of therapy, but still might benefit from it. In spite of this, theclinicians do not give enough care to the ankle and foot in RA patients, especially if asymptomatic, resulting future deformities, joint damage and feet disability. In order to show the importance of the feet and ankles in RA patients and to demonstrate the indispensable role of ultrasonography (US) for that purpose, at the same time displaying the US abnormalities that should draw our attention, we performed this review of the literature.
Exploring the Efficacy of a Safe Cryotherapy Alternative: Physiological Temperature Changes From Cold-Water Immersion Versus Prolonged Cooling of Phase-Change Material
Authors: Kwiecien Susan Y. , McHugh Malachy P. , Goodall Stuart , Hicks Kirsty M. , Hunter Angus M. , Howatson Glyn 
Published: April 2019

Purpose: To evaluate the effectiveness between cold-water immersion (CWI) and phase-change-material (PCM) cooling on intramuscular, core, and skin-temperature and cardiovascular responses. Methods: In a randomized, crossover design, 11 men completed 15 min of 15°C CWI to the umbilicus and 2-h recovery or 3 h of 15°C PCM covering the quadriceps and 1 h of recovery, separated by 24 h. Vastus lateralis intramuscular temperature at 1 and 3 cm, core and skin temperature, heart-rate variability, and thermal comfort were recorded at baseline and 15-min intervals throughout treatment and recovery. Results: Intramuscular temperature decreased (P < .001) during and after both treatments. A faster initial effect was observed from 15 min of CWI (Δ: 4.3°C [1.7°C] 1 cm; 5.5°C [2.1°C] 3 cm; P = .01). However, over time (2 h 15 min), greater effects were observed from prolonged PCM treatment (Δ: 4.2°C [1.9°C] 1 cm; 2.2°C [2.2°C] 3 cm; treatment × time, P = .0001). During the first hour of recovery from both treatments, intramuscular temperature was higher from CWI at 1 cm (P = .013) but not 3 cm. Core temperature deceased 0.25° (0.32°) from CWI (P = .001) and 0.28°C (0.27°C) from PCM (P = .0001), whereas heart-rate variability increased during both treatments (P = .001), with no differences between treatments. Conclusions: The magnitude of temperature reduction from CWI was comparable with PCM, but intramuscular temperature was decreased for longer during PCM. PCM cooling packs offer an alternative for delivering prolonged cooling whenever application of CWI is impractical while also exerting a central effect on core temperature and heart rate.
Acute Responses to On-Court Repeated-Sprint Training Performed With Blood Flow Restriction Versus Systemic Hypoxia in Elite Badminton Athletes
Authors: Valenzuela Pedro L. , Sánchez-Martínez Guillermo , Torrontegi Elaia , Vázquez-Carrión Javier , González Manuela , Montalvo Zigor , Millet Grégoire P. 
Published: April 2019

Purpose: Repeated-sprint training (RS) is commonly conducted in normoxia, but its completion with localized (blood-flow restriction [BFR]) or systemic hypoxia has been proven effective for performance enhancement. Yet, few studies have applied these types of RS sessions in racket sports. The authors aimed to determine the acute responses to these types of training in elite badminton players. Methods: Eight male elite badminton players participated in this randomized crossover study. They performed 3 on-court RS sessions, each consisting of 3 sets of 10 repetitions of 10-s badminton-specific movements in normoxia (RSN), systemic normobaric hypoxia (RSH, FiO2 = 14%), or with BFR (RS-BFR, 40% arterial occlusion pressure). Performance, perceptual (ie, rating of perceived exertion), and physiological (ie, pulse saturation, muscle oxygenation, blood lactate, creatine kinase, heart-rate variability) responses were measured after each set and up to 48 h postsession. Results: RS-BFR induced a greater performance impairment (lower distance and accelerations) and a higher local perceived exertion in the legs than RSN and RSH (P < .05), whereas greater overall fatigue was reported with RSH (P < .05). RSH induced a lower saturation (P < .001), but no differences were observed in muscle oxygenation between conditions. No differences in creatine kinase or heart-rate variability were observed at any time point (from baseline up to 48 h after the session). Conclusions: RS-BFR—and, to a lower extent, RSH—resulted in impaired performance and a higher perceived strain than RSN. However, these 2 hypoxic methods do not seem to induce a long-lasting (post 24–48 h) physiological stress in elite badminton players.
Is Swimmers’ Performance Influenced by Wetsuit Use?
Authors: Gay Ana , López-Contreras Gracia , Fernandes Ricardo J. , Arellano Raúl 
Published: April 2019

Purpose: To observe changes in performance, physiological, and general kinematic variables induced by the use of wetsuits vs swimsuits in both swimming-pool and swimming-flume conditions. Methods: In a randomized and counterbalanced order, 33 swimmers (26.46 [11.72] y old) performed 2 × 400-m maximal front crawl in a 25-m swimming pool (with wetsuit and swimsuit), and their mean velocities were used later in 2 swimming-flume trials with both suits. Velocity, blood lactate concentration, heart rate (HR), Borg scale (rating of perceived exertion), stroke rate, stroke length (SL), stroke index, and propelling efficiency were evaluated. Results: The 400-m performance in the swimming pool was 0.07 m·s−1 faster when using the wetsuit than when using the swimsuit, evidencing a reduction of ∼6% in time elapsed (P < .001). Maximal HR, maximal blood lactate concentration, rating of perceived exertion, stroke rate, and propelling efficiency were similar when using both swimsuits, but SL and stroke index presented higher values with the wetsuit in both the swimming pool and the swimming flume. Comparing swimming conditions, maximal HR and maximal blood lactate concentration were lower, and SL, stroke index, and propelling efficiency were higher when swimming in the flume than when swimming in the pool with both suits. Conclusions: The 6% velocity improvement was the result of an increase of 4% in SL. Swimmers reduced stroke rate and increased SL to benefit from the hydrodynamic reduction of the wetsuit and increase their swimming efficiency. Wetsuits might be utilized during training seasons to improve adaptations while swimming.