bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of bifucosylated glycoforms using low‐energy CID spectra
Authors: Ács András , Turiák Lilla , Révész Ágnes , Vékey Károly , Drahos László 
Published: September 2019

AbstractWe have used tandem mass spectrometry (MS/MS)‐based analysis of glycopeptides in order to identify the composition and structure of rare glycoforms. The results illustrate utility of low‐energy MS/MS for structure identification. We have shown the presence of bifucosylated and trifucosylated glycoforms in human α‐1‐acid glycoprotein (AGP), a major plasma glycoprotein. Fucosylation in the case of AGP always occurs on the antennae; core fucosylation was not observed.
Induction of peripheral blood T follicular helper cells expressing ICOS correlates with antibody response to hepatitis B vaccination
Authors: Xing Mingluan , Feng Yonghui , Yao Jun , Lv Huakun , Chen Yongdi , He Hanqing , Wang Zhifang , Hu Chonggao , Lou Xiaoming 
Published: September 2019

AbstractT follicular helper (TFH) cells, a critical subset of CD4+ T cells, provide help to B cells during the procession of the humoral immune response in the germinal center (GC) and extrafollicular sites. CXCR5+CD4+ T cells in human circulating blood, referred to herein as peripheral TFH (pTFH) cells, share phenotypes and functional properties with TFH cells in GC. Hepatitis B vaccine protects about 60% of the chronic hepatitis C patients from hepatitis B. The immunological bases that lead to the induction of protective antibody response is not well understood. In the present study, the pTFH cells subsets were determined in 18 healthy controls (anti‐HBs ≥ 100 mIU/mL; HC), 21 nonresponders (anti‐HBs < 10 mIU/mL; NR), and 23 weak responders (10 mIU/mL ≤ anti‐HBs < 100 mIU/mL; WR) of chronic hepatitis patients upon routine hepatitis B vaccination. Though the frequency of the pTFH cell was equivalent in HC, WR, and NR, ICOS+pTFH cells in HC underwent expansion with increased IL‐21 secretion and production of serum anti‐HBs response at 4 weeks after a full course of hepatitis B vaccination. These changes were not shown in both NR and WR. Analysis of ICOS+pTFH cells represents a novel cellular determinant of the hepatitis B vaccine–induced humoral immune response, which may have relevance for design of hepatitis B vaccine.
Impact of Divalent Ions on Heavy Oil Recovery by in situ Emulsification
Authors: Lee Jungin , Babadagli Tayfun , Giesbrecht Russell 
Published: September 2019

AbstractMany reservoir formation brines are characterized by high salinity and contain high concentrations of divalent ions such as calcium, magnesium, and potassium. These challenging conditions can render the surfactants ineffective during chemical flooding for enhanced heavy oil recovery. Various brine types can have an impact on the stability of emulsions generated with chemicals as chemicals have various resistant levels toward hard divalent ions and salinities. To investigate the impact of brine hardness on heavy oil‐in‐water emulsion stability, glass tube experiments, microscopic visualization and sandpack flooding experiments, and Hele‐Shaw visualization experiments were conducted in this study under low‐salinity/hard‐brine, high‐salinity/hard‐brine conditions using commercial chemicals, which are designed for specific reservoir brine conditions. Recovery results demonstrated that complex colloidal solution introduced in the previous study with silica and Dodecyltrimethylammonium bromide (DTAB) along with screened chemicals from glass tube tests in this study can enhance heavy oil recovery significantly with an addition of low concentration of xanthan gum (Lee and Babadagli 2018). The results confirmed the robustness of the complex colloidal solution formula to enhance oil recovery with low concentration of polymer under any reservoir brine conditions. The study also demonstrates the potential of polymer as an emulsion stabilization additive for enhanced heavy oil recovery by in situ emulsion generation. Polymer effects seemed to be particularly dominant under the low‐salinity conditions than high‐salinity conditions.
Changes in Trauma‐Related Emotions Following Treatment With Dialectical Behavior Therapy for Posttraumatic Stress Disorder After Childhood Abuse
Authors: Görg Nora , Böhnke Jan R. , Priebe Kathlen , Rausch Sophie , Wekenmann Stefanie , Ludäscher Petra , Bohus Martin , Kleindienst Nikolaus 
Published: September 2019

AbstractDialectical behavior therapy for posttraumatic stress disorder (DBT‐PTSD) is a trauma‐focused therapy shown to reduce core PTSD symptoms, such as intrusions, hyperarousal, and avoidance. Preliminary data indicate effects on elevated trauma‐related emotions (e.g., guilt and shame) and possibly radical acceptance of the traumatic event. However, it is unclear if improvements in these variables are significant after controlling for changes in core PTSD symptoms and to what extent nonclinical levels are obtained. In the current study, 42 individuals who met criteria for PTSD after childhood abuse and were participating in a 3‐month residential DBT‐PTSD program were evaluated at the start of the exposure phase of DBT‐PTSD and the end of treatment; a nonclinical sample with a history of childhood abuse was the reference group. Multivariate analyses of variance and multivariate analyses of covariance controlling for change in core PTSD symptoms were used to evaluate changes in several elevated trauma‐related emotions (fear, anger, guilt, shame, disgust, sadness, and helplessness) and in radical acceptance. In a repeated measures multivariate analyses of variance, both elevated trauma‐related emotions and radical acceptance significantly improved during DBT‐PTSD, λ = 0.34, p < .001; η2 = .56; t(40) = −5.66, p < .001, SMD = 0.88, even after controlling for changes in PTSD symptoms, λ = 0.35, p < .001, η2 = .65; Λ = 0.86, p = .018, η2 = .14, respectively. Posttreatment, 31.0% (for acceptance) to 76.2% (for guilt) of participants showed nonclinical levels of the investigated outcomes, suggesting that both trauma‐related emotions and radical acceptance changed after the 3‐month residential DBT‐PTSD program.
CT‐Guided Percutaneous Laser Disc Decompression for Lumbar Discogenic Radiculopathy‐Performance of a Novel Combi‐Therapy
Authors: Asafu Adjaye Frimpong George , Aboagye Evans , Asafu‐Adjaye Frimpong Akosua , Coleman Nana Esi , Amankwah Pierre , Quansah Ato 
Published: September 2019

Background and ObjectivesOn the basis of reported immediate and short‐term excruciating pain by patients in the post‐procedural period of computed tomography (CT)‐guided percutaneous laser disc decompression (PLDD) in our clinic, we present our initial clinical experience with a novel combi‐therapy using a combination of CT‐guided PLDD and CT‐guided epidural nerve blocks, which proved effective in managing the pain.Study Design/Materials and MethodsA total of 100 patients who met the criteria for PLDD, underwent treatment for lumbar discogenic radiculopathy between 2014 and 2017. Fifty‐five percent of the patients were males and 45% were females with a mean age of 46.25 years. Ninety‐five patients underwent one level PLDD and five patients two‐level PLDD procedures. CT‐guided epidural nerve block with a combination of Bupivacaine, Lignocaine, and Kenalog was used in a 3× procedure separated by a 1‐week interval. The first nerve block was given the same day, immediately after the PLDD procedure. The visual analogue scale (VAS) for pain was used during the pre‐procedure and post‐procedure periods.ResultsAmong the patients who underwent one level PLDD, 88 had L4–L5 levels, 5 had L5–S1 levels and 2 had L3–L4 levels. L4–L5 and L5–S1 levels were the most common two‐level PLDD locations in seven patients. Five patients in our study subsequently underwent open surgical treatment. All patients reported immediate pain relief, which was sustained after the procedure. The average pre‐procedure VAS score was 7.6 (range from 5 to 8.2) and the VAS score immediately after the procedure was on average 0.5 (ranging from 0 to 2).ConclusionsFindings from this initial experience using a combi‐therapy of CT‐guided PLDD and CT‐guided epidural nerve block have shown the benefits of this novel approach, offering significant immediate pain relief in the post‐procedural phase, favorable outcomes in the short to mid‐term and a significantly reduced rate of re‐surgery (7%) compared with the use of only CT‐guided PLDD. Lasers Surg Med 00:1–5, 2019. © 2019 Wiley Periodicals, Inc.
Nitrogen‐based corrosion inhibitor film study using weight loss and electrochemical methods in static and turbulent conditions
Authors: de Freitas Denise S. , Verdasco Javier Alejandro C. , Lima Lisiane G. , Gonçalves Israel L. M. , Rabelo Rodrigo B. , Poltronieri Olívia C. C. , Ewbank Conrado G. , de Rezende Fabíola C. , Kinouti Lílian 
Published: September 2019

AbstractThere is an increasing demand from oil and gas industry to ensure the integrity of assets and the enviroment in the critical conditions found in presalt wells. This study evaluates new formulations of corrosion inhibitors with different types and alkoxylation degrees of nitrogen‐based inhibitors to assess corrosion behavior of carbon steel (API X65). For these studies, corrosion rates were determined through measurements of weight loss and linear polarization resistance (LPR). In the case of electrochemical measurements, experiments were carried out in a laminar flow and in a turbulent flow regime. All data were collected in the presence of CO2 and CO2/H2S mixtures. The results revealed that corrosion protection of carbon steel critically depends on the nitrogen‐based inhibitor's alkoxylation type and degree as well as the condition to which they are exposed. It was possible to notice that an ethoxylated amine whose inhibition efficiency in the presence of CO2 was about 10%, when exposed to H2S environment at the same temperature showed an efficiency of 86%. It was also observed that the inhibitor with a higher ethoxylation degree presented better efficiencies than the one with a lower degree.
On the gonality of stable curves
Authors: Coelho Juliana , Sercio Frederico 
Published: September 2019

AbstractIn this paper we use admissible covers to investigate the gonality of a stable curve C over . If C is irreducible, we compare its gonality to that of its normalization. If C is reducible, we compare its gonality to that of its irreducible components. In both cases we obtain lower and upper bounds. Furthermore, we show that four admissible covers constructed give rise to generically injective maps between Hurwitz schemes. We show that the closures of the images of three of these maps are components of the boundary of the target Hurwitz schemes, and the closure of the image of the remaining map is a component of a certain codimension‐1 subscheme of the boundary of the target Hurwitz scheme.
Pathogenic effect of a TGFBR1 mutation in a family with Loeys–Dietz syndrome
Authors: Cozijnsen Luc , Plomp Astrid S. , Post Jan G. , Pals Gerard , Bogunovic Natalija , Yeung Kak K. , Niessen Hans W. M. , Goumans Marie‐José T. H. , Barge‐Schaapveld Daniela Q. C. M. , Micha Dimitra 
Published: September 2019

AbstractBackgroundThoracic aortic aneurysms and dissections (TAAD) may have a heritable cause in up to 20% of cases. We aimed to investigate the pathogenic effect of a TGFBR1 mutation in relation to TAAD.MethodsCo‐segregation analysis was performed followed by functional investigations, including myogenic transdifferentiation.ResultsThe c.1043G>A TGFBR1 mutation was found in the index patient, in a deceased brother, and in five presymptomatic family members. Evidence for pathogenicity was found by the predicted damaging effect of this mutation and the co‐segregation in the family. Functional analysis with myogenic transdifferentiation of dermal fibroblasts to smooth muscle‐like cells, revealed increased myogenic differentiation in patient cells with the TGFBR1 mutation, shown by a higher expression of myogenic markers ACTA2, MYH11 and CNN1 compared to cells from healthy controls.ConclusionOur findings confirm the pathogenic effect of the TGFBR1 mutation in causing TAAD in Loeys–Dietz syndrome and show increased myogenic differentiation of patient fibroblasts.
De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy
Authors: Tarailo‐Graovac Maja , Zahir Farah R. , Zivkovic Irena , Moksa Michelle , Selby Kathryn , Sinha Sunita , Nislow Corey , Stockler‐Ipsiroglu Sylvia G. , Sheffer Ruth , Saada‐Reisch Ann , Friedman Jan M. , van Karnebeek Clara D. M. , Horvath Gabriella A. 
Published: September 2019

AbstractBackgroundProfiling the entire genome at base pair resolution in a single test offers novel insights into disease by means of dissection of genetic contributors to phenotypic features.MethodsWe performed genome sequencing for a patient who presented with atypical hereditary sensory and autonomic neuropathy, severe epileptic encephalopathy, global developmental delay, and growth hormone deficiency.ResultsAssessment of the variants detected by mapped sequencing reads followed by Sanger confirmation revealed that the proband is a compound heterozygote for rare variants within RETREG1 (FAM134B), a gene associated with a recessive form of hereditary sensory and autonomic neuropathy, but not with epileptic encephalopathy or global developmental delay. Further analysis of the data also revealed a heterozygous missense variant in DNM1L, a gene previously implicated in an autosomal dominant encephalopathy, epilepsy, and global developmental delay and confirmed by Sanger sequencing to be a de novo variant not present in parental genomes.ConclusionsOur findings emphasize the importance of genome‐wide sequencing in patients with a well‐characterized genetic disease with atypical presentation. This approach reduces the potential for misdiagnoses.
Wohin mit dem f‐Block?
Authors: Steinhauser Georg 
Published: September 2019

AbstractWenn man sich die zahlreichen Versionen des Periodensystems ansieht, bekommt man den Eindruck, dass der f‐Block dort platziert werden darf, wo gerade Platz ist oder es schön aussieht. Doch für den radiophilen Anorganiker gibt es nur eine richtige Position.
Licht und Leuchten bei 3d‐Metallen
Authors: Heinze Katja , Förster Christoph , Vöhringer Peter , Sarkar Biprajit 
Published: September 2019

AbstractKomplexe von 3d‐Metallen wie Chrom, Eisen oder Kupfer haben ähnliche Eigenschaften wie photochemisch aktive Komplexe der Edelmetalle. Sie sind daher eine ökonomisch und ökologisch sinnvolle Alternative.
A convergence study of monolithic simulations of flow and deformation in fractured poroelastic media
Authors: Hageman Tim , de Borst René 
Published: September 2019

SummaryA consistent linearisation has been carried out for a monolithic solution procedure of a poroelastic medium with fluid‐transporting fractures, including a comprehensive assessment of the convergence behaviour. The fracture has been modelled using a subgrid scale model with a continuous pressure across the fracture. The contributions to the tangential stiffness matrix of the fracture have been investigated to assess their impact on convergence. Simulations have been carried out for different interpolation orders and for Non‐Uniform Rational B‐Splines as interpolants vs Lagrangian polynomials. To increase the generality of the results, Newtonian as well as non‐Newtonian (power‐law) fluids have been considered. Unsurprisingly, a consistent linearisation invariably yields a quadratic convergence but comes at the expense of a loss of symmetry and recalculation of the contribution of the interface to the stiffness matrix at each iteration. When using a linear line search, however, the inclusion of only those terms of the interface stiffness that result in a symmetric and constant tangential stiffness matrix is sufficient to obtain a stable and convergent iterative process.
A concept for aortic dissection with fluid‐structure‐crack interaction
Authors: Schussnig Richard , Fries Thomas‐Peter 
Published: September 2019

AbstractIn aortic dissection, the layers composing the aorta rupture, allowing blood to enter the vessel wall. This process is modeled applying a monolithic fluid‐structure interaction framework, formulating the Navier‐Stokes equations for incompressible flows as well as the mixed finite strain elastodynamics equations in the Lagrangian frame of reference. Continuous test‐ and trial function spaces are employed in the whole domain, rendering the coupling straightforward. Within this contribution, a predefined function indicating failure is used to convert solid to fluid elements, thereby mimicing tissue rupture.
Space–time variational methods for Maxwell's equations
Authors: Hauser Julia I. M. , Steinbach Olaf 
Published: September 2019

AbstractThe efficient and accurate numerical solution of the time–dependent Maxwell equations is one of the most challenging tasks, see, e.g., [1]. Besides semi–discretization methods such as the method of lines and Laplace transformation approaches, space–time variational formulations became popular in recent years. Here the variational principle is applied simultaneously in space and time, which later requires the solution of the global linear system of algebraic equations. But this can be done in parallel, and the space–time formulation allows for an adaptive resolution of the solution in space and time simultaneously. Following previous work [3,5] on the acoustic wave equation we present two variational formulations for the solution of the electromagnetic wave equation.
Examining teachers’ perceptions of K‐11 students’ 21st century skills and student performance
Authors: Woods‐Groves Suzanne , Choi Taehoon , Bruhn Allison Leigh , Fernando Josephine 
Published: September 2019

AbstractThis study examined the relationship of teachers’ ratings of students’ 21st century skills (i.e., persistence, curiosity, externalizing and internalizing affect, and cognition) via the Human Behavior Rating Scale: Brief (HBRS: Brief; Eaves & Woods‐Groves, 2011) with student performance. Midwestern K‐11 teachers (n = 96) rated students (n = 1,689) via the HBRS: Brief and the Strengths and Difficulties Questionnaire (SDQ; Goodman, 1997). Students’ academic (i.e., standardized tests) and behavioral (i.e., office discipline referrals [ODRs] and absences) performance was compared with HBRS: Brief ratings. Hierarchical linear modeling revealed that teachers’ ratings of students’ 21st century skills were related to the following: (a) Persistence with SDQ conduct problems, academic performance, and absences; (b) curiosity with SDQ emotional symptoms; (c) externalizing affect with SDQ conduct problems, academic performance, and ODRs; (d) internalizing affect with SDQ emotional symptoms and academic performance, and (e) cognition with academics.
Riesenatome mit Dreh
Authors: Bergamini Andrea , Hannema Gwenael , Zemp Armin 
Published: September 2019

ZusammenfassungPhononische Kristalle sind ein modernes Forschungsgebiet der Physik und der Ingenieurwissenschaften. Von der Festkörperphysik inspiriert verspricht man sich neuartige Metamaterialien, die als „Werkstoffe“ lasttragend und schwingungsisolierend sind. Entscheidend sind niederfrequente Bandlücken, welche die Ausbreitung langwelliger Schwingungen wegdämpfen. Dies ist aber je nach Anwendungsfall nur eingeschränkt möglich, solange die „Atome“ dieser periodischen Strukturen als Punktmassen in einem einfachen Masse‐Feder‐System behandelt werden. Man kann aber zusätzlich die Trägheit der makroskopischen und somit geometrisch ausgedehnten „Atome“ gezielt einsetzen. Das ermöglicht sehr leichte oder steife phononische Kristalle mit den erwünschten niederfrequenten Bandlücken.
Die Beute des Wanderfalken
Authors: Müller Thomas 
Published: September 2019

ZusammenfassungSeit Juni 2018 untersucht die japanische Raumsonde Hayabusa 2 den Asteroiden Ryugu. Dieser nur 900 m große Körper besitzt eine scharfkantige, oktaederförmige Form. Die praktisch homogene Oberfläche mit einer Albedo von nicht einmal 5 % ist übersät mit Gesteinsbrocken. Spektren deuten auf Hydroxylionen, also chemisch im Gestein gebundenes Wasser, hin. Die sehr geringe Dichte spricht für eine hoch poröse Struktur und lässt sich am besten durch eine lose Geröllansammlung erklären. Es wurden zudem erfolgreich mehrere Landeeinheiten abgesetzt, unter anderem die kastenförmige Sonde MASCOT. Außerdem hat Hayabusa 2 Oberflächenmaterial entnommen, das im Dezember 2020 die Erde erreichen soll.
Salt‐Treated Roots of Oryza australiensis Seedlings are Enriched with Proteins Involved in Energetics and Transport
Authors: Yichie Yoav , Hasan Mafruha T. , Tobias Peri A. , Pascovici Dana , Goold Hugh D. , Van Sluyter Steven C. , Roberts Thomas H. , Atwell Brian J. 
Published: September 2019

AbstractSalinity is a major constraint on rice productivity worldwide. However, mechanisms of salt tolerance in wild rice relatives are unknown. Root microsomal proteins are extracted from two Oryza australiensis accessions contrasting in salt tolerance. Whole roots of 2‐week‐old seedlings are treated with 80 mM NaCl for 30 days to induce salt stress. Proteins are quantified by tandem mass tags (TMT) and triple‐stage Mass Spectrometry. More than 200 differentially expressed proteins between the salt‐treated and control samples in the two accessions (p‐value <0.05) are found. Gene Ontology (GO) analysis shows that proteins categorized as “metabolic process,” “transport,” and “transmembrane transporter” are highly responsive to salt treatment. In particular, mitochondrial ATPases and SNARE proteins are more abundant in roots of the salt‐tolerant accession and responded strongly when roots are exposed to salinity. mRNA quantification validated the elevated protein abundances of a monosaccharide transporter and an antiporter observed in the salt‐tolerant genotype. The importance of the upregulated monosaccharide transporter and a VAMP‐like protein by measuring salinity responses of two yeast knockout mutants for genes homologous to those encoding these proteins in rice are confirmed. Potential new mechanisms of salt tolerance in rice, with implications for breeding of elite cultivars are also discussed.