bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humans Use Forward Thinking to Exert Social Control
Authors: Na Soojung , Chung Dongil , Hula Andreas , Jung Jennifer , Fiore Vincenzo G. , Dayan Peter , Gu Xiaosi 
Published: August 2019

SummarySocial control, the ability to exert influence over others, is critical in interpersonal interactions yet uninvestigated. Here, we used functional neuroimaging and a social exchange paradigm in which people’s current choices either did, or did not, influence their partners’ proposals in the future. Computational modeling revealed that participants used forward thinking and calculated the downstream effects of their current actions regardless of the controllability of the social environment. Furthermore, greater levels of estimated control correlated with better performance in controllable interactions and less illusory beliefs about control in uncontrollable interactions. Neural instantiation of trial-by-trial values of social controllability were tracked in the ventromedial prefrontal cortex (vmPFC), striatum, and insula for controllable interactions, but only in vmPFC for uncontrollable interactions. These findings demonstrate that humans use forward thinking, a strategy similar to model-based planning, to guide social choices; and that subjective beliefs about social controllability might not be grounded in reality.
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse and widespread in the environment
Authors: Pedroso Marcelo Monteiro , Waite David W. , Melse Okke , Wilson Liam , Mitić Nataša , McGeary Ross P. , Antes Iris , Guddat Luke W. , Hugenholtz Philip , Schenk Gerhard 
Published: August 2019

AbstractAntibiotic resistance has emerged as a major global health threat. The Zn2+-dependent metallo-β-lactamases (MBLs) are of particular concern as they act on the most widely prescribed class of antibiotics, the β-lactams, and are largely unaffected by commonly used β-lactamase antagonists such as clavulanic acid. MBLs are subdivided into three groups (B1 to B3); despite low overall sequence similarity, their catalytic centers are conserved with two closely spaced Zn2+ binding sites (α and β site). We recovered almost 1500 B3 MBLs from >100,000 public microbial genomes representing a wide range of habitats including pristine sites not impacted by human activity. Although homologs were predominantly identified in members of the bacterial phylum Proteobacteria, the recovered B3 MBLs represent a much broader phylogenetic diversity than is currently appreciated based on the study of model pathogens. This includes three active site variants inferred to have arisen from the ancestral B3 enzyme. One of these variants, B3-RQK, is noteworthy for being broadly sensitive to clavulanic acid. Through targeted mutations we demonstrate that the presence of a lysine residue (Lys263) in the β site of the catalytic center of this variant confers sensitivity to this compound. Replacing this lysine with the canonical histidine (His263) found in all other MBLs restored resistance. Crystallographic and computational data reveal that clavulanic acid inhibits B3-RQK MBLs by displacing the Zn2+ ion in the β site. Therefore, modifying clavulanic acid to effectively interact with His263 may increase the therapeutic range of this widely used antibiotic resistance drug.SignificanceThis study surveys the environmental and phylogenetic diversity of the B3 subgroup of antibiotic-degrading metallo-β-lactamases (MBLs). B3-like MBLs are more widespread in the environment than previously appreciated suggesting multiple unrecognized reservoirs of antibiotic resistance. Three variants of the canonical active site were identified, including B3-RQK, which amongst the B3 MBLs is uniquely inhibited by the antibiotic resistance drug clavulanic acid. We demonstrate that the mode of inhibition involves the displacement of a catalytically essential Zn2+ ion from the active site. It may thus be possible to modify clavulanic acid so that it can compete with the Zn2+ ions in other MBLs as well, increasing the therapeutic range of this compound.
Readthrough errors purge deleterious cryptic sequences, facilitating the birth of coding sequences
Authors: Kosinski Luke , Masel Joanna 
Published: August 2019

AbstractDe novoprotein-coding innovations sometimes emerge from ancestrally non-coding DNA, despite the expectation that translating random sequences is overwhelmingly likely to be deleterious. The “pre-adapting selection” hypothesis claims that emergence is facilitated by prior, low-level translation of non-coding sequences via molecular errors. It predicts that selection on polypeptides translated only in error is strong enough to matter, and is strongest when erroneous expression is high. To test this hypothesis, we examined non-coding sequences located downstream of stop codons (i.e. those potentially translated by readthrough errors) inSaccharomyces cerevisiaegenes. We identified a class of “fragile” proteins under strong selection to reduce readthrough, which are unlikely substrates for co-option. Among the remainder, sequences showing evidence of readthrough translation, as assessed by ribosome profiling, encoded C-terminal extensions with higher intrinsic structural disorder, supporting the pre-adapting selection hypothesis. The cryptic sequences beyond the stop codon, rather than spillover effects from the regular C-termini, are primarily responsible for the higher disorder. Results are robust to controlling for the fact that stronger selection also reduces the length of C-terminal extensions. These findings indicate that selection acts on 3′ UTRs inS. cerevisiaeto purge potentially deleterious variants of cryptic polypeptides, acting more strongly in genes that experience more readthrough errors.
Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome
Authors: Park Sang Ho , Ayoub Alex , Lee Young Tae , Xu Jing , Kim Hanseong , Zhang Wei , Zhang Biao , An Sojin , Zhang Yang , Cianfrocco Michael A. , Su Min , Dou Yali , Cho Uhn-Soo 
Published: August 2019

SUMMARYMixed Lineage Leukemia (MLL) family histone methyltransferases are the key enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanism by which the MLL complexes recognize histone H3K4 within the nucleosome core particle (NCP) remains unclear. Here, we report the single-particle cryo-electron microscopy (cryo-EM) structure of the human MLL1 core complex bound to the NCP. The MLL1 core complex anchors on the NCP through RbBP5 and ASH2L, which interacts extensively with nucleosomal DNA as well as the surface close to histone H4 N-terminal tail. Concurrent interactions of RbBP5 and ASH2L with the NCP uniquely align the catalytic MLL1SET domain at the nucleosome dyad, allowing symmetrical access to both H3K4 substrates within the NCP. Our study sheds light on how the MLL1 complex engages chromatin and how chromatin binding promotes MLL1 tri-methylation activity.
Characterizing allele-by-environment interactions using maize introgression lines
Authors: Li Zhi , Tirado Sara B. , Kadam Dnyaneshwar C. , Coffey Lisa , Miller Nathan D. , Spalding Edgar P. , Lorenz Aaron J. , de Leon Natalia , Kaeppler Shawn M. , Schnable Patrick S. , Springer Nathan M. , Hirsch Candice N. 
Published: August 2019

AbstractRelatively small genomic introgressions containing quantitative trait loci can have significant impacts on the phenotype of an individual plant. However, the magnitude of phenotypic effects for the same introgression can vary quite substantially in different environments due to allele-by-environment interactions. To study potential patterns of allele-by-environment interactions, fifteen near-isogenic lines (NILs) with >90% B73 genetic background and multiple Mo17 introgressions were grown in 16 different environments. These environments included five geographical locations with multiple planting dates and multiple planting densities. The phenotypic impact of the introgressions was evaluated for up to 26 traits that span different growth stages in each environment to assess allele-by-environment interactions. Results from this study showed that small portions of the genome can drive significant genotype-by-environment interaction across a wide range of vegetative and reproductive traits, and the magnitude of the allele-by-environment interaction varies across traits. Some introgressed segments were more prone to genotype-by-environment interaction than others when evaluating the interaction on a whole plant basis throughout developmental time, indicating variation in phenotypic plasticity throughout the genome. Understanding the profile of allele-by-environment interaction is useful in considerations of how small introgressions of QTL or transgene containing regions might be expected to impact traits in diverse environments.Key MessageSignificant allele-by-environment interactions are observed for traits throughout development from small introgressed segments of the genome.
Process improvement capability: a study of the development of practice(s)
Authors: Jones Oliver , Gold Jeff , Claxton Julia 
Published: August 2019

PurposeThe purpose of this paper is to report on a research project, using intervention research (IR), which aims to identify how a higher education institution could develop process improvement (PI) capability.Design/methodology/approachThe paper adopts a practice perspectives of routines, and classifies and catalogues the potential routines that could form PI capability. The development of these routines are investigated using the constructive research approach, a form of IR), in the action research mode. Within this approach, the methodology of mediated discourse analysis was employed to trace the empirical trajectory of the routine development, in a student management office within the context of an improvement project by the institutions PI unit.FindingsOf relative significance is the implication that there is a small group of initialising PI practices which are accessible to practitioners, in contrast to a large set of critical success factors. Second, these PI practices transcend particular methodologies, meaning their development can be incorporated into customised, contextualised methodologies, by individual organisations.Practical implicationsThe set of PI practices identified are able to be enacted by practitioners and are not dependent on macro-management factors. Second they are relatively simple to understand and are not associated with any particular improvement fad or fashion.Originality/valueThe study contributes to the appreciation of PI in higher education as a capability, and outlines the potential array of routines that could constitute that capability. It provides a theoretical view on how key PI routines are developed in an organisational field, and a more nuanced and richer view of “process mapping” and its effect on other PI practices.
Vegoganic AB: the dilemma of arsenic in rice products
Authors: Rotter Julia P. , Mark-Herbert Cecilia M. 
Published: August 2019

Learning outcomes
This teaching case aims to stimulate the debate over the issue of arsenic in rice and prepares students to make a decision by evaluating trade-offs and aligning moral values in a business context.

Case overview/synopsis
Rice feeds people in many parts of the world. This teaching case focuses on an entrepreneurial food producer who has strong sustainability values built into his business model. The CEO, Johan Henriksson, of Vegoganic faces a dilemma when a press release by the Swedish National Food Agency potentially threatens the core existence of the business. It challenges the CEO to take a stand on food safety and food security, as well as personal and societal values.

Complexity academic level
It is a discussion case, developed with undergraduate students in mind, but could be taken to a graduate level by including more advanced literature and questions.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing
Organizational success, human resources practices and exploration–exploitation learning
Authors: Ubeda-Garcia Mercedes , Claver-Cortés Enrique , Marco-Lajara Bartolome , Garcia-Lillo Francisco , Zaragoza-Sáez Patrocinio 
Published: August 2019

PurposeThe purpose of this paper is twofold: first, to analyze which policies of human resource management (HRM) contribute to exploratory learning and which to exploitation learning; and second, to determine the influence of the two types of learning on organizational performance.Design/methodology/approachThe research hypotheses are tested by partial least squares with data from a sample of 100 Spanish hotels.FindingsThe results confirm that, in order of importance, selective staffing, comprehensive training and an equitable reward system lead to exploratory learning. Exploitative learning seems to be fundamentally driven by comprehensive training and an equitable reward system (but in a different way than with exploratory learning). Finally, both types of learning have a positive impact on performance.Practical implicationsBoth exploratory and exploitative learning result from HRM practices. To maintain performance expectations managers should develop both learning types, which entails the utilization of the best HRM practices.Originality/valueThis study presents empirical evidence around the findings of other studies (Laursen and Foss, 2014; Minbaeva, 2013) which call for further research into whether strategic HRM configurations have positive effects on the two learning types. The results find some practices that have a positive effect in both cases, but with different intensities in their explanations. This finding reveals the need for more detailed exploration around which combinations of HRM practices, in terms of exploratory vs exploitative learning, are advisable for organizations. The study also finds that the two learning types have a positive influence on organizational performance.
Agency as the achievement of reform ownership
Authors: Godfrey Lauren , Olson Carol Booth 
Published: August 2019

PurposeThe purpose of this study is to explore how, through the cultivation of reform ownership in the professional development (PD) program, the Pathway Project, agency was achieved for the development of teacher professionalism and teacher expertise in the cases of Mrs. Cruz and Mrs. Keyes. This, in turn, provided opportunities to advance student learning.Design/methodology/approachMultiple sources of data (focused classroom observations, semi-structured interviews and collected artifacts) were analyzed through a case study approach to understand the processes by which an agentic context materialized for these two teachers.FindingsThe authors identified the following three stages in the cultivation of reform ownership in the cases of Mrs. Cruz and Mrs. Keyes: emerging; developing; and deepening. Each of these stages proved critical to the achievement of agency for the development of teacher professionalism, teacher expertise and student learning.Originality/valueThe cases of Mrs. Cruz and Mrs. Keyes offer a renewed vision of the ways in which teachers can achieve agency in the current reform environment. Given the proliferation of reform efforts within today’s educational landscape, their cases suggest that PD developers take seriously the responsibility of cultivating reform ownership for the achievement of agency and deep and lasting change.
Choice-experiment-method-based research into the future improvement of Beijing’s urban forest
Authors: Zhao Zheng , Wen Yali 
Published: August 2019

Purpose
The purpose of this paper is to measure the influence factors of their preferences for urban forest, marginal values of various properties and relative values of different scheme portfolios, thus arriving indirectly at the city residents’ demand for urban forest improvement.

Design/methodology/approach
This paper, based on the data from the 2015–2017 field survey questionnaire of city residents over the radius of Beijing’s 5th Ring Road, uses the choice experiment method (CEM) to conduct a study of its residents’ demand for urban forest.

Findings
Beijing’s city residents are generally inclined to accept a relatively low payment of urban forest while hoping to access a relatively high urban afforestation coverage with the construction of relatively many city parks, especially focusing on the specialized park management; the marginal values of biodiversity and greenery coverage are far higher than those of greenbelts in quantity and the maximum marginal value of biodiversity remains as high as RMB29.42, indicating that the city residents do not favor much the number of greenbelts over other aspects but they generally hope to achieve a higher greenery coverage and a richer biodiversity.

Research limitations/implications
Generally speaking, what Beijing City needs most is not continuing the increase in the number of greenbelts, but engaging in the rational retrofit of its existing greenbelts and optimizing its urban forest structure.

Originality/value
This paper may provide reference for determining the city residents’ payment criteria for urban forest and will be of equally great significance to developing cities and their urban forest.
Analysis of the influencing factors on China’s forestry economic growth based on grey correlation model
Authors: Ke Shuifa , Qiao Dan , Chen Zhangchun 
Published: August 2019

Purpose
The purpose of this paper is to analyze the influence of different factors on forestry production, with an aim to explore the degree of connection between forestry economic growth and influencing factors such as forestry investment, labor input, afforestation area, scientific and technologies progress, and the reform of property-rights regimes.

Design/methodology/approach
According to the data of China Forestry Statistical Yearbook from 1978 to 2017, this paper uses the grey correlation analysis to observe and analyze the factors influencing China’s forestry economics growth.

Findings
The results show that capital investment demonstrates the largest impact on the forestry output value, followed by property system, afforestation area, labor input and technologies progress. The correlation coefficients of the above factors are 0.874451654,0.85827468,0.835138412,0.832985604 and 0.825747493. This means that forestry capital investment plays a major role in contributing to forest economic growth; forest property system also plays a positive role in the growth of forestry economy.

Originality/value
This paper uses continuous data collected during 1978‒2017, which are quite extensive as compared to data used in the existing research, considering the influencing factors are comprehensive, especially the impact of property right system reform on forestry economic growth.
Memory objects and boarding school trauma
Authors: Jack Christine Trimingham , Devereux Linda 
Published: August 2019

Purpose
The purpose of this paper is to provide language and meaning to open up silence around traumatic boarding school memories through the symbolic aura (Nora 1989) surrounding key memory objects. The secondary aim is to illustrate to historians the importance of paying attention to interviewees’ discussion of material objects as clues to uncovering deeper, unexplored memories.

Design/methodology/approach
The approach draws on Vamik Volkan’s (2006) understanding of “linking objects” – significant objects preserved or created by traumatised people. Traumatic emotions become linked with loss and grief associated with the object, turning it into a tightly packed symbol whose significance is “bound up in the conscious and unconscious nuances of the relationship that preceded the loss” (Volkan, 2006, p. 255). The experiences of the two authors are examined as exemplars in this process.

Findings
The exemplars illustrate how complicated and long term the process of remembering and understanding is for those who experience boarding school trauma and the power of “linking objects” to open up memory surrounding it. The case studies also alert educational historians to how emotionally fraught revealing what happened can be and how long it may take to confront the events.

Originality/value
Linking objects have not previously been used in relationship to surfacing boarding school trauma. The paper is also unique in offering deep analysis of boarding school trauma undertaken by skilled educational researchers who incorporate reflections from their own experience informed by broad theory and pertinent psychological research.
Effect of natural resources extraction on energy consumption and carbon dioxide emission in Ghana
Authors: Kwakwa Paul Adjei , Alhassan Hamdiyah , Adu George 
Published: August 2019

Purpose
Even though many studies have attempted to understand the drivers of carbon dioxide emission and energy consumption to help tackle environmental issues, not much has been done to estimate the effect of natural resources extraction on these two variables. This paper aims to analyze the long-run and short-run carbon dioxide emission and energy consumption effect of natural resources extraction in Ghana.

Design/methodology/approach
The theoretical foundation for this study is the Stochastic Impacts Regression on Population, Affluence and Technology (STIRPAT) model. Secondary Data sourced from World Development Indicators (2018) for the period of 1971-2013 were used. Estimation was done by using the autoregressive distributed lag.

Findings
It was found among other things that urbanization, and extraction of natural resources contribute to Ghana’s carbon dioxide emission, while official development assistance helps in reducing carbon dioxide emission in the long run. Again, while income and extraction of natural resources increase energy consumption, urbanization and official development assistance reduce environmental degradation in the long run. Regarding the short run, income and urbanization both increase energy consumption and carbon dioxide emission; trade openness and official development assistance decrease both carbon dioxide emission and energy consumption.

Research limitations/implications
The implications from the results include the need to strictly enforce laws regulating extractive activities in the country to ensure a safe environment; and also to raise tariff and non-tariff barriers on products that do not promote a friendly environment and vice versa.

Originality/value
The effect of natural resources extraction on carbon emission and energy consumption is examined.