bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diverticular bleeding in the third part of the duodenum as a cause of overt obscure gastrointestinal bleeding
Authors: Hamada Yasuhiko , Nakagawa Hayato 
Published: November 2024

AbstractA 65‐year‐old man with a history of chronic renal failure and ischemic heart disease who was receiving aspirin therapy was admitted for recurrent melena. Initial evaluation revealed severe anemia. Other than a diverticulum in the third part of the duodenum, the findings of upper and lower gastrointestinal endoscopies and computed tomography were unremarkable. Capsule endoscopy detected altered blood in the ileum; however, balloon‐assisted enteroscopy found no definitive source of bleeding. Three years later, he presented with recurrent melena and hemorrhagic shock. Upper gastrointestinal endoscopy identified Dieulafoy's lesion within the duodenal diverticulum. Hemostasis was achieved using hemoclips. No recurrence of bleeding was observed during 4 years of follow‐up. The findings from this case highlight the diagnostic and therapeutic challenges of managing obscure gastrointestinal bleeding due to Dieulafoy's lesion in a diverticulum in the third part of the duodenum. Duodenal diverticular bleeding should be included in the differential diagnoses for patients with obscure gastrointestinal bleeding.
BK Polyomavirus DNAemia With a High DNA Load Is Associated With De Novo Donor‐Specific HLA Antibodies in Kidney Transplant Recipients
Authors: Moest Wouter T. , de Vries Aiko P. J. , Roelen Dave L. , Kers Jesper , Moes DirkJan A. R. , van der Helm Danny , Mallat Marko J. K. , Meziyerh Soufian , van Rijn Aline L. , Feltkamp Mariet C. W. , Rotmans Joris I. 
Published: November 2024

ABSTRACTBK polyomavirus‐associated nephropathy (BKPyVAN) is a well‐known complication of kidney transplantation (KTx). The mainstay of prevention is the reduction of immunosuppression upon detection of BK polyomavirus (BKPyV) DNAemia, which precedes BKPyVAN. However, this reduction may inadvertently increase the risk of alloimmunity particularly in patients with a high BKPyV DNA load, where significant immunosuppression reduction is often necessary. This single‐center, retrospective cohort study assesses the risk of de novo donor‐specific antibodies (dnDSA) development and biopsy‐proven acute rejection (BPAR) following high and low BKPyV DNAemia. All patients who underwent KTx at Leiden University Medical Center between 2011 and 2020 were included. Patients were grouped according to high (maximum BKPyV DNA load > 4log10 copies/mL), low (maximum serum BKPyV DNA load ≤ 10E4 copies/mL), and absent BKPyV DNAemia, and analyzed for the development of dnDSA and BPAR, using Cox regression. Of 1076 KTx recipients included, 108 (10%) developed a BKPyV DNAemia with a maximum DNA load below 4log10 copies/mL, whereas 121 (11.2%) developed a BKPyV DNAemia exceeding 4log10 copies/mL. The risk of dnDSA development was higher in patients with a high BKPyV DNAemia, compared to patients without DNAemia (adjusted hazard ratio of 1.9 (95% CI 1.1–3.2, p = 0.017). No significant difference in dnDSA risk was observed between patients with low and absent BKPyV DNAemia. Risk of BPAR did not differ between groups. Our study shows that higher BKPyV DNA loads in KTx patients are associated with a higher risk for dnDSA development, highlighting the importance of exploring additional strategies for the prevention and treatment of BKPyV infections in KTx recipients.
The Risk Assessment of Uveitis After Monkeypox Diagnosis: A Multicenter Population‐Based Study
Authors: Hsu Alan Y. , Kuo Hou‐Ting , Wu Bing‐Qi , Wang Yu‐Hsun , Lin Chun‐Ju , Hsia Ning‐Yi , Lai Chun‐Ting , Chen Huan‐Sheng , Tsai Yi‐Yu , Wei James Cheng‐Chung 
Published: November 2024

ABSTRACTThe risks of uveitis development among monkeypox (MPOX) patients are unclear. To determine the uveitis risks after (MPOX) diagnosis. Population‐based, retrospective cohort study used the TriNetX database and recruited those with and without MPOX diagnosis from January 1, 2016, to December 31, 2023. The non‐MPOX cohort consisted of randomly selected control patients matched by covariates, including age, gender, ethnicity, race, relevant comorbidities, previous medications, and the inflammatory marker C‐reactive protein. Statistical analysis on uveitis risk included hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated over 8 years (2016–2023). A separate analysis of the risk of uveitis among MPOX patients aged 20 years and older was also conducted. (MPOX) diagnosis, identified using electronic diagnostic codes. Cumulative incidence of new‐onset uveitis. A total of 5449 MPOX patients of all ages (25.45% female; mean age at index 35.17 ± 15.70 years) and 5449 propensity‐matched non‐MPOX comparators (23.97% female; mean age at index 35.30 ± 15.91 years) were recruited from the TriNetX database. For both the overall MPOX patient population and the adult MPOX patients, the risk of uveitis was significantly higher compared to the non‐MPOX cohort. This increased risk mainly happened in patients with anterior uveitis. Specifically, the hazard ratio for uveitis in all MPOX patients was 2.59 (95% CI: 1.40–4.79). Among MPOX patients aged 20 years or older, the hazard ratio for uveitis was 2.14 (95% CI: 1.17–3.94). There is a notable association between new‐onset uveitis and patients with MPOX. Our real‐world findings underscore the importance of being aware of the potential risk of anterior uveitis in this patient population.
Understanding Risk Factors for Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Insights From a 10‐Year Study Comparing Conditioning Regimens
Authors: Erat Tuğba , Bozkaya İkbal Ok , Mustafaoğlu Özlem , Kanbur Şerife Mehtap , Gülhan Belgin , Kanık‐Yüksek Saliha , Özkaya‐Parlakay Aslınur , Özbek Namık Yaşar 
Published: November 2024

ABSTRACTHematopoietic stem cell transplantation is a curative therapy for pediatric patients with malignancies and blood or immune system disorders. However, recipients are at risk of opportunistic infections, including cytomegalovirus infection, due to immunosuppression from conditioning regimens. This retrospective study analyzed 439 pediatric hematopoietic stem cell transplantation patients to identify risk factors for cytomegalovirus infection and assess the impact of conditioning regimens. Significant factors included graft source, graft versus host disease, and pre‐transplant clinically significant cytomegalovirus infection. Myeloablative conditioning regimens and the use of anti‐thymocyte globulin increased the risk of clinically significant cytomegalovirus infection. Additionally, the risk of cytomegalovirus infection in patients was found to be statistically significant in the myeloablative subgroup analyses who received anti‐thymocyte globulin alone and those who received both anti‐thymocyte globulin and total body irradiation. In our study, total body irradiation did not significantly affect the risk of clinically significant cytomegalovirus infection. This study covers a 10‐year period and a large pediatric patient population from a single center. Our findings highlight the importance of understanding risk factors for clinically significant cytomegalovirus infection to guide preventive strategies in pediatric HSCT recipients.
Future Climate Change in the Northern Bering Sea
Authors: Overland James E. , Wang Muyin 
Published: November 2024

ABSTRACTThe Bering Sea is undergoing major changes from increasing winter temperatures to the north, extreme minimum sea‐ice years in 2018 and 2019, through to an ecosystem reorganisation and negative impacts on communities' economic and subsistence food resources. These events have emerged under a global warming background, with positive feedback processes through a weakened atmospheric Alaskan Arctic Front (AAF) that promotes a self‐reinforcing process of sea‐ice loss, warmer air and sea temperatures, a wavy jet stream, and southerly winds. Interannual variability is still important: during 2021–2024 the Aleutian Low‐pressure system was regionally dominant in supporting a strong AAF, and sea‐ice conditions were observed close to the climatological mean. Before 2017, the AAF, consisting of cold dry air mass to the north and moist relatively warm air mass to the south, was a barrier to northward movement of storms, keeping the northern Bering/Chukchi seas with a cold Arctic climate. That historical situation is ending. Of critical importance is the probable reoccurrence of low Bering Sea sea‐ice years over the next decades and related ecosystem impacts. We propose that radically low sea ice will have a frequency of one to three 2018‐like low sea‐ice events per decade in the coming two decades, based on a historical meteorological analysis and ensemble climate model projections. Arctic temperatures to the north are increasing, weakening their contribution to the AAF. A weakened AAF and low sea‐ice years needs the winter Aleutian low pressure system to be far to the west of its average position, with southerly rather than northeasterly winds, warm years and low sea‐ice extent. From 1948 to 2024 meteorological records, this western location occurred with a range of zero to three times per decade. Communities need to plan for a response to intermittent occurrence of 2018‐like extreme sea‐ice loss and their ecosystem impacts over the coming decades.
Spatiotemporal Characteristics of Precipitation Concentration and Their Linkage to Temperature Over China
Authors: Lin Zequn , Wang Dagang , Du Yi , Meng Yue 
Published: November 2024

ABSTRACTPrecipitation concentration represents the temporal unevenness of precipitation over a given period. A higher concentration increases the likelihood of concurrent flooding and drought. While previous studies have primarily focused on precipitation concentration at the daily scale, research on sub‐daily scales remains limited. Furthermore, the impact of temperature on precipitation concentration across various temporal scales is not well understood. In this study, we utilise high‐resolution precipitation products and the Gini index (GI) to examine the spatiotemporal characteristics of precipitation concentration across four different time scales (3, 6, 12‐h and 1‐day) over China. The climatological analysis reveals a gradual increase in precipitation concentration from southeast to northwest China. At shorter temporal scales (3 and 6‐h), Southeastern China exhibits a notable increase in precipitation concentration, while longer scales (12‐h and 1‐day) show a significant decrease throughout most regions of Northwest China. These observed spatiotemporal patterns are closely linked to temperature variations. At the 3‐h scale, precipitation concentration at the 3‐h scale increases with temperature at a nation‐averaged rate of 1.06% °C−1 and decreases to 0.30% °C−1 at the 1‐day scale. Higher temperatures intensify precipitation concentration at the 3‐h scale in Southeast China by increasing the frequency of heavy precipitation events. Meanwhile, in Northwest China, the decline in concentration at the daily scale under warmer conditions is attributed to increased annual precipitation amounts driven by higher temperatures. This study is of great significance, as it provides insight into how the temporal distribution of precipitation in China change under future global warming.
Development of a Non‐Covalent Molecularly Imprinted Polymer via Precipitation Method for the Selective Separation of D‐Xylose From Sugarcane Residues
Authors: Borges Luís Fernando Tavares , Wong Ademar , Silva Weida Rodrigues , Sotomayor Maria D. P. T. 
Published: November 2024

ABSTRACTThe agro‐industry generates substantial waste, necessitating eco‐friendly solutions. This study introduces a novel molecularly imprinted polymer (MIPs) for the selective separation of D‐xylose from sugarcane residues. A non‐covalent imprinted polymer was synthesized via precipitation and optimized through D‐xylose adsorption assays. The polymer demonstrated an Imprinting Factor of 3.34, adsorption equilibrium within 30 min, notable reusability retaining over 95% of its adsorption capacity after three cycles, and high selectivity coefficients (α > 2.00) for all saccharides tested. The adsorption isotherm followed the Langmuir model. Characterization confirmed successful imprinting, with the imprinted polymer exhibiting a surface area of 69.4 m2/g and pore volume of 0.26 cm3/g, compared to 8.7 m2/g and 0.03 cm3/g for the non‐imprinted polymer. D‐xylose separation was tested using hemicellulosic hydrolysate from sugarcane straw and bagasse. The polymer applied as a sorbent in dispersive solid‐phase extraction with the hydrolysate achieved 90.29 ± 1.27% D‐xylose adsorption. Desorption in pure water recovered 81.48 ± 1.22% of the adsorbed D‐xylose. This method advances separation techniques, offering an efficient solution for sample pre‐treatment and expanding the application of MIPs.
Comparison of Two Analytical Techniques of Biomass Burning Markers in PM1 and PM2.5 From Zabrze, Southern Poland
Authors: Janoszka Katarzyna , Jaworek Katarzyna , Klyta Justyna 
Published: November 2024

ABSTRACTWith increasing attention to alternative energy sources due to environmental concerns, biomass emerges as a promising solution. However, biomass combustion emits particulate matter and harmful substances, impacting air quality and human health. The study compares gas chromatography‐mass spectrometry (GC‐MS) and high‐performance anion‐exchange chromatography with pulsed amperometric detection (HPAEC‐PAD) methods for biomass combustion marker determination. GC‐MS involves derivatization and subsequent analysis, while HPAEC‐PAD utilizes water extraction, bypassing derivatization. Both methods' analytical performance characteristics were compared, showing HPAEC‐PAD to have slightly lower detection limits and simplified sample preparation. The comparison revealed similar concentrations of levoglucosan and mannosan between the methods. However, galactosan (GA) concentrations showed discrepancies, possibly due to method sensitivity and recovery. HPAEC‐PAD exhibited advantages in GA detection due to its direct analysis and better recovery. The study highlights the suitability of HPAEC‐PAD for biomass combustion marker analysis, especially for GA determination, owing to its simplicity. However, GC‐MS offers advantages in complex matrix identification. The findings provide insights for future research on atmospheric aerosol analysis and comparative studies of analytical techniques for other monosaccharides.
Trail cameras can greatly inflate nest predation rates
Authors: Henden John‐André , Ims Rolf Anker , Strømeng Marita Anti 
Published: November 2024

AbstractPhotographic monitoring currently provides the most accurate means for identifying nest predators and eventually their role in bird population declines worldwide. However, previous studies have found that commercially available trail cameras represent an artificial structure that tend to negatively bias predation rates, likely through predator neophobia. Based on an experiment in Arctic tundra, involving 50 artificial nests and 30 cameras in each of 2 breeding seasons, we demonstrated that trail cameras attracted corvids (in particular ravens [Corvus corax]), which caused an extreme and positively biased predation rate that was consistent over a range of experimental and environmental conditions. We call for new technologies that allow for photographic monitoring of bird nests with minimal visual footprints, in the form of smaller cameras and more efficient internal batteries to minimize novel and conspicuous external features detectable by predators. However, even such improved devices need to be assessed with respect to potential effects on nest predation in each case.
A membrane inlet laser spectrometer for in situ measurement of triple water isotopologues
Authors: Wohleber Axel , Blouzon Camille , Witwicky Julien , Ginot Patrick , Jourdain Nicolas C. , Grilli Roberto 
Published: November 2024

AbstractWe describe a novel compact autonomous in situ sensor for semi‐continuous measurement of water isotopes (δD, δ18O, and δ17O) in liquid water. The sensor relies on a dual‐inlet water vapor injection system based on the pervaporation through a semi‐permeable membrane, and on the water vapor composition analysis using a dedicated optical feedback cavity enhanced absorption spectrometer. The sensor has dimensions of 165 mm diameter and 550 mm long, for a weight of ∼ 8 kg. A titanium casing allows applications down to 6000 m deep for a total effective weight of 45 (23) kg in air (water). It has a power consumption of ∼ 40 W, and an autonomy of 10–12 h which is ensured by a dedicated Li‐ion battery pack. The sensor is equipped with single‐pair high‐speed digital subscriber line communication for telemetry purposes. The instrument provides an accuracy of 0.3‰ (2σ) for all water isotopes with a 9‐min integration time. The instrument is suitable for investigating the freshwater cycle in the ocean, and in particular the transformation of ocean water masses related to iceberg and ice shelf melting.
Neurotensin Conjugated Polymeric Porous Microparticles Suppress Inflammation and Improve Angiogenesis Aiding in Diabetic Wound Healing
Authors: Narisepalli Saibhargav , Salunkhe Shubham A. , Chitkara Deepak , Mittal Anupama 
Published: November 2024

AbstractNeurotensin (NT), a bioactive tridecapeptide aids in diabetic wound healing by modulating inflammation and angiogenesis. However, its rapid degradation in peptidase‐rich wound environment (plasma half‐life <2 min) limits its efficacy. To address this, neurotensin‐conjugated polymeric porous microparticles (NT‐PMP) were developed and loaded in gelatin (hydrogel 15% w/v) for topical application, enabling sustained NT release to enhance therapeutic outcomes. NT‐PMP exhibited a size range of 60 – 240 µm (mean: 120.63 ± 40.71 µm) and pore size of 5 – 16 µm (average: 10.68 ± 3.47 µm). In vitro studies demonstrated cytocompatibility of NT‐PMP in fibroblasts and reduced TNF‐α levels in inflammation‐induced macrophages (1256 ± 167.02 pg/ml). Further NT‐PMP scaffold depicted excellent cell adhesion and migration properties upon seeding of dermal fibroblasts on surface of PMPs. In vivo studies in diabetic wound rat model demonstrated effective wound management, characterized by notable regenerative and healing attributes in the presence of NT‐PMP. This included complete re‐epithelialization, reducing pro‐inflammatory cytokine (TNF‐α), and enhancing VEGF expression, ultimately leading to the development of a well‐organized collagen matrix in diabetic wounds upon application of NT‐PMP gel.Altogether, NT conjugated PMP loaded in hydrogel demonstrated significant regenerative and healing properties, suggesting its potential as an alternative treatment for diabetic wounds.
On non‐Hopf Ricci‐pseudosymmetric hypersurfaces in CP2$\mathbb {C}P^{2}$ and CH2$\mathbb {C}H^{2}$
Authors: Cui Qianshun , Hu Zejun 
Published: November 2024

AbstractIn this paper, we study an open problem raised by Cecil and Ryan [Geometry of Hypersurfaces, Springer Monographs in Mathematics, p. 531] which asked whether there exist non‐Hopf Ricci‐pseudosymmetric hypersurfaces in and . As our main results, we first prove the nonexistence of non‐Hopf Ricci‐pseudosymmetric hypersurfaces of the constant type in . Then, we prove the existence of non‐Hopf Ricci‐pseudosymmetric hypersurfaces of the constant type in . Finally, applying the preceding results and sharpening Theorem 4.1 of Wang and Zhang [J. Geom. Phys. 181 (2022), 104648], we prove the nonexistence of non‐Hopf weakly Einstein hypersurfaces with constant norm of Riemannian curvature tensor in both and .
Embedded trace operator for infinite metric trees
Authors: Franceschi Valentina , Naderi Kiyan , Pankrashkin Konstantin 
Published: November 2024

AbstractWe consider a class of infinite weighted metric trees obtained as perturbations of self‐similar regular trees. Possible definitions of the boundary traces of functions in the Sobolev space on such a structure are discussed by using identifications of the tree boundary with a surface. Our approach unifies some constructions proposed by Maury, Salort, and Vannier for discrete weighted dyadic trees (expansion in orthogonal bases of harmonic functions on the graph and using Haar‐type bases on the domain representing the boundary), and by Nicaise and Semin and Joly, Kachanovska, and Semin for fractal metric trees (approximation by finite sections and identification of the boundary with a interval): We show that both machineries give the same trace map, and for a range of parameters we establish the precise Sobolev regularity of the traces. In addition, we introduce new geometric ingredients by proposing an identification with arbitrary Riemannian manifolds. It is shown that any compact manifold admits a suitable multiscale decomposition and, therefore, can be identified with a metric tree boundary in the context of trace theorems.
Abstract integro‐differential equations with state‐dependent integration intervals: Existence, uniqueness, and local well‐posedness
Authors: Hernandez Eduardo , Pandey Shashank , Pandey Dwijendra N. 
Published: November 2024

AbstractIn this work, we study a new class of integro‐differential equations with delay, where the informations from the past are represented as an average of the state over state‐dependent integration intervals. We establish results on the local and global existence and qualitative properties of solutions. The models presented and the ideas developed will allow the generalization of an extensive literature on different classes of functional differential equations. The last section presents some examples motivated by integro‐differential equations arising in the theory of population dynamics.
Construction of the log‐convex minorant of a sequence {Mα}α∈N0d$\lbrace M_\alpha \rbrace _{\alpha \in \mathbb {N}_0^d}$
Authors: Boiti Chiara , Jornet David , Oliaro Alessandro , Schindl Gerhard 
Published: November 2024

AbstractWe give a simple construction of the log‐convex minorant of a sequence and consequently extend to the ‐dimensional case the well‐known formula that relates a log‐convex sequence to its associated function , that is, . We show that in the more dimensional anisotropic case the classical log‐convex condition is not sufficient: convexity as a function of more variables is needed (not only coordinate‐wise). We finally obtain some applications to the inclusion of spaces of rapidly decreasing ultradifferentiable functions in the matrix weighted setting.
Numerische Untersuchungen zum Einfluss des Nennlochspiels auf die Plattennachgiebigkeit von hochfest vorgespannten Schraubenverbindungen
Authors: Dörre M. , Glienke R. , Kalkowsky F. , Wegener F. , Flügge W. 
Published: November 2024

AbstractGeschraubte Verbindungen stellen insbesondere für Mischbauweisen, endbeschichtete Halbzeuge, aber auch für wartungsgerechte Konstruktionen ein hocheffizientes Fügeverfahren dar, welches die konstruktive Gestaltung maßgeblich beeinflusst. Für die Bemessung solcher Verbindungen in den Bereichen des Maschinen‐ und Anlagenbaus bildet die VDI 2230–1 die Berechnungsbasis. Um Problemen der Form‐ und Lagetoleranzen in der Montage von Bauteilen und Baugruppen zu begegnen und so den reibungslosen Fertigungsablauf zu ermöglichen, werden Durchgangslöcher in den Bauteilen oftmals als übergroße Rund‐ oder Langlöcher ausgeführt. Das erhöhte Nennlochspiel findet in den Rechenschritten R0 bis R13 zur Berechnung hochbeanspruchter zylindrischer Einschraubenverbindungen nach der VDI Richtline 2230–1 jedoch keine Berücksichtigung, was zu einer Überdimensionierung oder Hilfskonstruktionen führt. Oftmals lässt sich die Nachweisführung in der Praxis nur durch kostenintensive Einzelfalluntersuchungen auf Basis von Versuchen stützen. Die in diesem Beitrag gezeigten Untersuchungen zur Bestimmung der Druckverteilung in der Trennfuge, der Schraubennachgiebigkeit sowie des Einflusses der Lochgeometrie auf die Plattennachgiebigkeit haben die Bereitstellung einer grundlegenden Datenbasis für die Erarbeitung eines analytischen Berechnungsmodells nach VDI 2230–1 für Schraubenverbindungen mit erhöhtem Nennlochspiel zum Ziel.