bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification, ecological evaluation and phylogenetic analysis of non‐symbiotic endophytic fungi colonizing timothy grass and perennial ryegrass grown in adjacent plots
Authors: Przemieniecki Sebastian Wojciech , Damszel Marta , Kurowski Tomasz Paweł , Mastalerz Jędrzej , Kotlarz Karol 
Published: January 2019

AbstractNon‐systemic endophytes coexist with grasses and produce positive or negative effects for the host. In agricultural grasses, endophytes such as Epichloë spp. (formerly: Neotyphodium spp.) enhance the biometric parameters and agricultural value of grass biomass and seeds. Some endophytic fungi produce active substances that exert a negative influence on grass‐fed livestock. There is a general scarcity of studies investigating other endophytic fungi, the species composition of fungal communities, fungal species capable of colonizing different grasses and endophyte transfer between grass taxa. This study aims to fill in the existing knowledge gap by describing the relationships between fungal species and grass species. Timothy grass (Phleum pratense L.) is more readily colonized by endophytic fungi than perennial ryegrass (Lolium perenne L.), and the ratio of fungi isolated from the above species was determined at 3:1. Ecological indicators, especially diversity, were also higher in the fungal community colonizing timothy grass. The vast majority of the isolated fungi were ascomycetes. In addition, two Basidiomycota isolates and three Oomycota isolates (Phythium acanthicum) were also obtained from timothy grass. The most prevalent fungal species were Alternaria alternata, Microdochium bolleyi and Epicoccum nigrum. An analysis of minisatellite DNA regions revealed high levels of genetic polymorphism in A. alternata, whereas the remaining isolates were characterized by low levels of genetic variation or genetic homogeneity. The transfer of endophytic fungi between grass species was determined, which was one of the most important observations made in the study. The Sørensen–Dice coefficient reached 50%, which indicates that all fungal species isolated from perennial ryegrass are capable of colonizing timothy grass.
Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity
Authors: Usui Ryota , Yabe Daisuke , Seino Yutaka 
Published: January 2019

Unimolecular peptide‐based dual agonists against glucagon‐like peptide‐1 receptor (GLP‐1R) and glucose‐dependent insulinotropic polypeptide receptor (GIPR) have been gaining much attention recently as novel antidiabetic agents that can potentially control glycemia and bodyweight. Although GLP‐1 and GIP both enhance insulin secretion and subsequently ameliorate postprandial glucose excursion, most research has focused on GLP‐1R as a therapeutic target for type 2 diabetes. This is partly because the effects of GIPR activation on glycemia and bodyweight have been controversial. GIPR‐deficient mice showed impaired glucose tolerance with reduced β‐cell function and resistance to high‐fat diet‐induced obesity, whereas GIPR agonists improved glycemia and prevented high‐fat diet‐induced obesity in mice. Conflicting results in mice might be explained by pharmacological levels of GIP signal in the central nervous systems decreasing food intake and overcoming the obesogenic effects of GIP at physiological levels in adipose tissues. Thus, GIPR activation at pharmacological levels might result in bodyweight reduction. Indeed, bodyweight reduction by GIPR/GLP‐1R dual agonists was greater than GLP‐1R single agonists in individuals with type 2 diabetes. Thus, GLP‐1R/GIPR dual agonists can add additional therapeutic efficacy to tailored diabetes care, especially among obese individuals with type 2 diabetes. However, caution should be exercised as to whether or not these drugs are appropriate for the management of Asian type 2 diabetes patients, which are primarily characterized by non‐obesity and impaired β‐cell function, as well as in that of elderly adults with type 2 diabetes, who tend to develop sarcopenia and frailty as a result of poor energy intake.
Capital Regulation with Two Banking Sectors: Cyclicality and Implementation
Authors: KIM TAEJIN , MANGLA VISHAL 
Published: January 2019

AbstractWe present a capital regulation policy in a model in which banks can choose to be unregulated, by operating in the shadow banking sector, when the cost of being regulated (restriction on portfolio risk) exceeds the benefit (cheaper funding/insurance). We show that the welfare maximizing capital requirement policy can be procyclical: lower requirement during booms and higher requirement during recessions. Our policy specifies the level of capital requirement as a function of the observed relative size of the unregulated and regulated banking sectors. This specification achieves the optimal aggregate risk exposure by obtaining the right mix of the two sectors.
Odorella benthonica gen. & sp. nov. (Pleurocapsales, Cyanobacteria): an odor and prolific toxin producer isolated from a California aqueduct
Authors: Shalygin Sergei , Huang I‐Shuo , Allen Elle H. , Burkholder JoAnn M. , Zimba Paul V. 
Published: January 2019

Pleurocapsales are one of the least understood groups of cyanobacteria in terms of molecular systematics and biochemistry. Considering the high number of cryptic taxa within the Synechococcales and Oscillatoriales, it is likely that such taxa also occur in the Pleurocapsales. The new genus described in our research is the first known pleurocapsalean cryptic taxon. It produces off‐flavor and a large number of bioactive metabolites (n = 38) some of which can be toxic including four known microcystins. Using a polyphasic approach, we propose the establishment of the genus Odorella with the new species O. benthonica from material originally isolated from the California Aqueduct near Los Angeles.
Stress and uncertainty in parents of children with tracheobronchial malacia and stenosis
Authors: Ho Shing‐Huey , Soong Wen‐Jue , Wang Kai‐Wei K 
Published: January 2019

ABSTRACTBackgroundAn increasing number of children are undergoing flexible bronchoscopy because of tracheobronchial malacia and stenosis, but there is little research related to their parents' stress and uncertainty.AimTo explore and identify risk factors associated with stress and uncertainty among Taiwanese parents of children with tracheobronchial malacia and tracheabronchostenosis in a paediatric intensive care unit.MethodsA cross‐sectional study design was implemented using two psychometric scales: Parenting Stress Index and Parents' Perception of Uncertainty Scale. Parents of Taiwanese children (0–18 years/o) with a diagnosis of tracheobronchial malacia or/and tracheabronchostenosis who underwent bronchoscopy in a paediatric intensive care unit were recruited. The analysis used descriptive statistics and multivariable linear regression.ResultsNinety parents who were caring for a total of 51 children were recruited. Stress and uncertainty both scored high and were positively correlated with each other. Four risk factors arising from parental stress were unemployment, parental uncertainty, the child's tracheobronchial malacia and tracheabronchostenosis and use of oxygen.ConclusionsIdentifying likely causes of stress and uncertainty is essential for this parental group, particularly for parents facing unemployment, feelings of uncertainty and caring for children with both tracheobronchial malacia and tracheabronchostenosis and requiring oxygen.Relevance to clinical practiceNursing practice can focus on better parental support for those parents who are unemployed, show feeling of uncertainty and care for children with combined tracheobronchial malacia and tracheabronchostenosis and other medical care, such as breathing symptom management, nasogastric feeding and oxygen therapy.
Criniviruses associated with cucurbit yellows disease in Greece and Cyprus: an ever‐changing scene
Authors: Orfanidou C. G. , Papayiannis L. C. , Pappi P. G. , Katis N. I. , Maliogka V. I. 
Published: January 2019

Cucurbit yellow stunting disorder virus (CYSDV), Cucurbit chlorotic yellows virus (CCYV) and Beet pseudo‐yellows virus (BPYV) are whitefly‐transmitted criniviruses that cause foliar interveinal yellowing symptoms and result in high economic losses for cucurbit production. CYSDV and CCYV are transmitted by Bemisia tabaci, whereas BPYV is transmitted by Trialeurodes vaporariorum. During 2012–2017, an extensive survey was conducted to identify the viruses causing cucurbit yellows disease in Greece and Cyprus. The study sampled the main cucurbits and alternative hosts in these regions to determine crinivirus incidence, to identify the whitefly species present in the two countries and to characterize molecularly the virus populations. Results showed that CYSDV was the most widespread virus in Greece (49.9%), followed by CCYV (20.3%) and BPYV (18.4%). Bemisia tabaci and T. vaporariorum were identified in 54.5% and 45.6% of whitefly samples, respectively. In Cyprus, CYSDV was predominant (96.7%), followed by CCYV (19.2%), while no BPYV infection was detected. Approximately 15% of weed samples from 17 different species that belong to 12 botanical families were identified as hosts for one or more of these criniviruses. Finally, sequencing of the capsid protein gene of the crinivirus isolates revealed very low levels of genetic diversity, further supporting the genetic stability of crinivirus populations. The results of this long‐lasting epidemiological study in two countries of the eastern Mediterranean revealed substantial changes in the relative incidence and distribution of cucurbit‐infecting criniviruses and their whitefly vectors over the past 15 years, suggesting the need for adoption of novel management strategies.
A topographically preserved road‐network tile model and optimal routing method for virtual globes
Authors: Dong Quanhua , Chen Jing , Liu Tingting 
Published: January 2019

AbstractVirtual globes enable the combination of heterogeneous datasets for optimal routing analyses in transportation, environmental ecology, and construction engineering. In this study, considering the advantages of the hierarchical tiling structure and topography of virtual globes, we propose a tile‐based optimal routing method for large‐scale road networks in a virtual globe. This method designs a topographically preserved road‐network tile model by partitioning roads into tiles and constructs the road‐network pyramid from the bottom to the top. During construction, a TileArc is calculated and flagged as the shortest path in a tile. Based on the built road‐network pyramid carrying hierarchical TileArcs, a multi‐level and flexible shortest path query can be executed efficiently. The proposed method is implemented with large road networks with different road grades in a virtual globe. Experimental results verify its validity, efficiency, and exactness. Moreover, the length of the shortest path with surface distance is approximately 1.3 times longer than that with Euclidean distance.
Provision of HIV services by community health workers should be strengthened to achieve full programme potential: a cross‐sectional analysis in rural South Africa
Authors: Naidoo N. , Matlakala N. , Railton J. , Khosa S. , Marincowitz G. , Igumbor J. O. , McIntyre J. A. , Struthers H. E. , Peters R. P. H. 
Published: January 2019

AbstractObjectiveSouth Africa's community health workers (CHWs) provide a bridge between the primary healthcare (PHC) facility and its community. We conducted a cross‐sectional analysis to determine the contribution of the community‐based HIV programme (CBHP) to the overall HIV programme.MethodsWe collected service provision data from the daily activity register of CHWs attached to 12 PHC facilities in rural Mopani District, South Africa. Personal identifiers of individuals referred to the facility for HIV services were recorded and verified against facility routine patient registers to determine the effectiveness of referral.ResultsHIV services were provided on 18 927 occasions; 30% of the total activities performed by CHWs during the study period. CHWs assessed 12 159 individuals for HIV risk (13% coverage of the study population); only 290 (2%) were referred for HIV testing services. Referral was effective in 213 (73%) individuals; evidence of an HIV‐positive status was found for 38 (18%) individuals. However, 30 (79%) of these individuals were referred by CHWs despite being on ART. Adherence support was provided during 5657 visits; only one individual was referred for complications. Finally, of the 864 individuals lost to the ART programme, CHWs managed to find 452 (52%) for referral back to the facility; only 241 (53%) of these were (re)initiated on ART.ConclusionsProvision of HIV services by CHWs should be strengthened to fully deliver on the programme's potential. Human resource investment, home‐based HIV testing and improved tracing models constitute potential strategies to enhance CHWs impact on the HIV programme.
Labour market characteristics and surviving import shocks
Authors: Chan Jeff 
Published: January 2019

AbstractThis paper investigates whether different labour market characteristics amplify or dampen the local labour market impacts from Chinese import competition exposure. I exploit state‐level variation in initial, pre‐shock labour market characteristics and regional variation across local labour markets in exposure to Chinese imports for identification. I find that local labour markets in states with higher union density experience more severe adverse consequences as a result of increased import exposure. Conversely, higher initial minimum wages help mute the negative impacts of the China shock. I also provide some evidence that exceptions to employment‐at‐will legislation can affect employment responses to increased Chinese imports. Finally, examining all policies together in an index, I show that higher levels of policies intended to benefit and protect workers can actually magnify the extent of the damage inflicted by import competition. My results suggest that initial labour market characteristics and policies can play an important role in understanding why local labour markets react differently to trade shocks.
Improving Quality Management Systems (QMS) for Pipeline Construction Activities
Authors: Gould Melissa , Etheridge Brad , Amend Bill , Bruce William A. 
Published: January 2019

Since 2007, the pipeline industry has experienced a large increase in pipeline construction. Construction inspections performed by the Department of Transportation (DOT) Pipeline Hazardous Materials Safety Administration (PHMSA) have revealed numerous quality issues. These inspections, coupled with several pre-commissioning pressure test failures, first year in-service failures, and other material and construction problems, brought construction quality to the attention of the oil and gas pipeline industry.
A proven method for improving quality in other industries is through the implementation of a quality management system (QMS). One widely accepted QMS used across industries is ISO 9001. Additionally, several QMS standards specific to the oil and gas industry have been developed. Due to the uniqueness of pipeline construction projects, PHMSA solicited proposals in 2013 for a research and development project titled, “Improving Quality Management Systems for Pipeline Construction Activities” which was awarded to and co-funded by DNV GL.
This paper describes the QMS framework for pipeline construction activities and an accompanying guidance document developed by DNV GL. The framework and guidance document are intended to assist pipeline operating companies and contractors in the development and implementation of a company-specific QMS, with a goal of elevating the focus on quality to the level of safety.
The framework adopts a risk-based, process approach, as defined in other QMS and management system documents, and follows the plan-do-act-check methodology. The QMS framework is designed to be scalable for a wide range of pipeline construction projects, including liquid and gas transmission pipelines and gas distribution lines. The framework includes the general management system components, as well as specific sections on implementation of a QMS for a pipeline construction project. The QMS framework and guidance document developed are intended to be used either as a stand-alone management system or as the quality component in a company’s corporate management system.
Capturing Best Practices for Third Party Inspections of Pipeline Construction
Authors: Montemurro David , McCaig Kim , Hoffmann Richard , Sahney Reena 
Published: January 2019

The North American pipeline industry is facing a time of significant expansion over the next decade as a result of market demand and technology advancements that have fundamentally shifted supply and demand patterns in North America. While recent commodity prices have softened, the need for pipeline infrastructure may only be somewhat delayed, still allowing industry opportunity to improve practices in a number of areas. The INGAA Foundation and the Canadian Energy Pipeline Association (CEPA) Foundation have a number of initiatives underway in this respect; in particular, there is an emphasis on improving quality in all aspects of the pipeline construction process. One of the initiatives, described in this paper, relates to the compilation of a guide and body of knowledge for inspection practices and captures best practices as they relate to third party inspection during the construction process. The outlined approach is intended to have two main philosophical underpinnings: it must complement existing practices, training and certification, and it must remain user friendly and practical to use.
The main challenge in capturing best practices in this area lies in striking an appropriate balance between specific guidance regarding third party inspection and overly prescriptive, specific company practices. This is further complicated due to the broad range of topics and information required that is not always consistently documented across member companies. In light of these realities, the approach for the Practical Guide for Pipeline Construction Inspection was to align material required to perform an inspection task tightly to the sequential construction process to allow an intuitive layout for new industry entrants. Once a working group, representing both US and Canadian Operators and Services providers was established, a detailed table of contents was developed and agreed to by the group. Using this simple framework, available Member Company information was then reviewed, assessed and captured in detail for inclusion in the guide. The information took a range of forms ranging from specifications, manuals to training documents and modules. Significant collaboration, through working sessions, with Subject Matter Experts (SMEs), used to review, revise and supplement the content, as required. Overall, this approach provided a technically sound guide, addressing gaps in codified industry knowledge, while remaining relevant and accessible for most users.
Upon completion, this body of knowledge will be available for member companies to use immediately, and potentially, as a basis for training, individual study, and the further refinement of existing industry certification.
Strain Capacity of Large Diameter Pipes: Full Scale Investigation With Influence of Girth Weld, Strip End Weld and Ageing Effects
Authors: Höhler Susanne , Karbasian Hossein , Gering Alexander , Kalwa Christoph , Ouaissa Brahim 
Published: January 2019

The strain capacity of pipes under combined loading is a significant research topic if the pipes are provided for Strain Based Design scenarios. Displacement controlled scenarios such as ground movements may significantly affect transmission pipelines by inducing large amounts of plastic axial strains, which need to be considered in the design process. For these combined loading cases with internal pressure combined with pronounced longitudinal strains from environmental conditions it is essential to evaluate critical deformations on the one hand and to conclude the required structural performance and material parameters, on the other hand. Also pipe laying procedures introduce axial strains in pipes and pipe strings, e.g. cold bending of pipes for onshore pipelines, or S-Laying of offshore pipelines in combination with external pressure. For these cases also the strain capacity of the pipes and pipe connections must be guaranteed. In any case, the structural behaviour needs to be checked via full-scale tests to confirm and validate engineering approaches and computational models.
This paper presents a full-scale test series of UOE pipe X70 (OD = 914 mm, WT = 14.1 mm) and Spiral welded pipe X70 (OD = 1016 mm, WT = 20 mm) subject to internal pressure and bending load. Full-scale 4-point-bending tests on pipe joints subject to internal pressure were performed. The test series included the influence of girth weld, strip end weld for spiral pipe, and ageing effects of thermal treatment from coating process. The local bending strains measured via strain gauges and via optical strain measurements in the bending zone are evaluated for the tensile and compressive zone and discussed with respect to existing buckling models.
The results of the full-scale test program confirmed that the weld connections of the pipe joints are capable of withstanding bending load. The effects of the girth weld and strip end weld during bending test are analyzed and discussed. The test results are extended by finite element simulations that widen the experimental parameter range.
Risk Profiling for the Pipeline Industry: Application of Best Practices From the Aviation Industry
Authors: Harron Lorna , Turner Kimberley 
Published: January 2019

Enbridge partnered with Aerosafe Risk Management to perform risk profiling to assist strategic planning activities aimed at safety performance improvement. A preliminary risk report, the first step towards an Industry Risk Profile (IRP) was the outcome. An IRP presents a strategic view of the risks within an industry sector at a point in time, requiring input from many stakeholders including operators, associations, and regulators. Most importantly, an IRP facilitates joint solutioning of risks to achieve improved safety performance and industry wide risk reduction. The preliminary risk report considered Enbridge data in addition to publically available information from associations and regulators to produce a preliminary risk report. The data gathering process considered information related to governance and oversight, compliance regime, assurance model, asset capabilities, industry operating environment, industry safety profile, and operator profile.
Results of the preliminary risk report are shared in this paper, with applicability to other operators, associations, and regulators. Providing the first building block of the IRP, these results focus on how organizations like Enbridge who aspire to participate or lead industry level reform or change can use the data to reshape their corporate risk based decision making. This approach, if adopted more broadly across the industry could provide as far reaching results as those seen in the aviation, military and transport sectors.
The IRP methodology and approach developed by Aerosafe in the mid-2000s, is now well entrenched in the aviation industry and is used by regulators and industry alike to create a pathway for industry level risk reduction and notable reform. The use of an IRP is considered best practices by the aviation, transport and regulatory sectors in the USA, Canada, Australia and New Zealand and after being in use in some sectors of aviation around the globe since 2008, the results are now measurable. These results provide a strong and clear link between safety performance improvement and the management and reduction of the industry risk profile.