bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting pathogen prevalence between tick and dog populations at Chornobyl
Authors: Dillon Megan N. , Qurollo Barbara A. , Thomas Rachael , Warren Madeline E. , Mousseau Timothy A. , Betz Jennifer A. , Kleiman Norman J. , Breen Matthew 
Published: November 2024

Abstract
Background
The 1986 disaster at the Chornobyl Nuclear Power Plant released massive amounts of radioactive material into the local environment. In addition to radiation, remediation efforts and abandonment of military-industrial complexes contributed to contamination with heavy metals, organics, pesticides and other toxic chemicals. Numerous studies have evaluated the effects of this contamination on the local ecology. However, few studies have reported the effect of this contamination on vector-borne pathogens and their hosts. In this manuscript, we characterize tick-borne pathogen presence at two sample locations within the Chornobyl Exclusion Zone, one at the Nuclear Power Plant (NPP) and another 16 km away in Chornobyl City (CC).

Methods
Ticks and whole-blood samples were collected from free-breeding dogs captured at the NPP and CC. Endpoint PCR and quantitative PCR were used to identify tick species and to assess the presence of specific tick-borne pathogens, including Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Babesia spp., Bartonella spp., Francisella tularensis and general Anaplasmataceae. A droplet digital PCR assay was developed for Babesia canis and A. phagocytophilum to evaluate their presence in dogs from the two populations. Pathogen prevalences between the two sample populations were compared by calculating Z-scores.

Results
Ticks were identified as Ixodes ricinus (n = 102) and Dermacentor reticulatus (n = 4). Overall, 56.9% of I. ricinus ticks were positive for at least one pathogen. A significantly higher prevalence of A. phagocytophilum and B. burgdorferi was found in ticks at the NPP (44.0% and 42.0%, respectively) compared to CC (23.1% and 19.2%, respectively). Babesia spp. (including B. canis and B. caballi) were detected in 8.8% ticks at similar proportions for both populations. Interestingly, we found a significantly lower level of A. phagocytophilum in dogs at the NPP (1.8%) than in dogs at CC (11.7%). In total, 24.3% of dogs were positive for B. canis, evenly distributed across the two populations.

Conclusions
The results of this study show contrasting pathogen prevalence in both ticks and dogs at the NPP and CC, which may reflect the differential exposures at the two locations. This work adds an important new component to our understanding of the consequences of prolonged exposure to environmental contamination on the wildlife and ecology within the Chornobyl Exclusion Zone.

Graphical Abstract
Preclinical evidence and possible mechanisms of cardioprotective effects of resveratrol in diabetic cardiomyopathy: a systematic review and meta-analysis
Authors: Yan Xiaodan , Hu Youjia , Zhao Shuyuan , Zhou Qian , Chen Qiu 
Published: November 2024

Abstract
Introduction
Diabetic cardiomyopathy (DCM) is a significant complication of diabetes, characterized primarily by the development of heart failure in individuals with diabetes. Numerous animal studies have indicated that resveratrol enhances cardiac function in diabetic cardiomyopathy; however, its reliability and underlying mechanism remain unclear. This study aims to assess the cardioprotective effects of resveratrol on DCM and explore its potential mechanism.

Methods
We searched PubMed, EMBASE, WOS, Cochrane Library, CNKI, CBM, Chinese VIP, and Wan Fang Database until March 31st, 2024, without language restrictions. Continuous outcome measures were analyzed using weighted mean difference or standardized mean difference, and heterogeneity was assessed with I2. The risk of bias in animal experiments was evaluated using the SYRCLE tool, and evidence reliability was determined with the GRADE tool. All data were analyzed using Review Manager 5.4.1 and Stata 17. This study has been registered on the PROSPERO (CRD42024523944).

Results
A total of 18 studies meeting the criteria were identified. The analysis revealed that the resveratrol intervention group exhibited significant improvements in LVEF (WMD = 17.88), LVFS (WMD = 8.77), HW/BW (SMD=-2.92), SOD (SMD = 4.53), and MDA (SMD=-5.07) compared to the control group. The GRADE grading assessment indicated moderate certainty for LVEF, HW/BW, and MDA, while certainty for other factors was considered low.

Conclusion
Our research suggests that resveratrol may protect cardiac function in DCM through anti-inflammatory and anti-oxidative stress effects. However, these findings are based on preclinical data, and further extensive trials are needed to confirm their effectiveness and safety before clinical application.
Architectural spatial distribution and network connectivity characteristics of ancient military towns in Southwest China: a case study of Qingyan Ancient Town in Guiyang
Authors: Zhao Yaxing , Xiang Huiwen , Huang Zongsheng 
Published: November 2024

Abstract
Due multiple influences, such as Tusi, Tunpu, and minority culture, Tunpu military towns in Southwest China have unique historical and cultural heritage. At present, the ancient Tunpu military towns are not widely known internationally. In order to understand the layout characteristics of Tunpu military buildings in southwest China since the Ming Dynasty, the spatial distribution and military attributes of Qingyan Ancient Town, a typical military town of Tunpu culture, are studied by using Thiessen polygons, fractal theories, and complex network methods. The findings indicate that architectural spaces in the six districts have high spatial self-similarity and low spatial complexity and are distributed in clusters primarily impacted by natural factors and supplemented by humanistic factors. The architectural space networks of the six districts have high stability, low vulnerability, poor balance, and high connectivity. They reflect its interior architectural layout, which is based on close cooperation between villagers and military, taking into account trade and cultural life. Differences in the functionality of buildings lead to differences in the connectivity of the spatial network of buildings; the hierarchical, graded, and differentiated characteristics of architectural spatial network connectivity are influenced by both nature and society. Non-military functions all serve or are subordinate to military functions. The spatial network connectivity of traditional settlement architecture reflects the interaction between nature and society. By studying a Tunpu military ancient town in the southwest, we can better understand the historical military activities, cultural connotations, social changes, and historical background of traditional settlements. The historical planning of the defence of traditional settlements both contributes to its cultural heritage and as an important reference and inspiration for modern planning and management.
Toward a data-informed framework for the assessment of digital readiness of higher education institutions
Authors: Chounta Irene-Angelica , Ortega-Arranz Alejandro , Daskalaki Sophia , Dimitriadis Yannis , Avouris Nikolaos 
Published: November 2024

AbstractThis paper aims to address Digital Readiness in Higher Education Institutions from the perspective of data-informed and evidence-based assessment of Digital Readiness. Related research suggests that existing instruments for assessing digitalization aspects are limited to self-assessment, and there is a need for data-informed frameworks that will allow automated assessments based on data that Higher Education Institutions already collect. To bridge this gap, we propose a conceptual, data-informed framework for assessing Digital Readiness in Higher Education Institutions. We followed a participatory approach informed by related theory and practice to design, together with stakeholders from three academic institutions in three European countries, a Digital Readiness assessment framework on seven dimensions accompanied by 72 data-informed indicators. Digitalization of Higher Education is a priority in political agendas, and educational institutions have acknowledged it as an opportunity to promote digitalization of teaching and learning, organizational structures, and technical services, enabling innovation and internationalization. We envision that this work contributes towards supporting educational institutions in self-reflecting upon their digitalization policies and practices.
Simultaneously resettable zero knowledge protocol in Public Key model
Authors: Zhu Wei , Deng Yi 
Published: November 2024

AbstractIn this paper, we construct a 6-round simultaneously resettable sound resettable $$(T, \epsilon )$$

(
T
,
ϵ
)

-zero knowledge protocol for $$\mathsf {NP \cap coNP}$$

NP
∩
coNP

in the Public Key model under standard assumptions, comparing with the 27-round simultaneously resettable zero knowledge protocol in the BPK model by Deng et al. in 2011, we have achieved a significant reduction in the round complexity. Our model assumes that both prover and verifier hold public keys, we call it the Public Key model. It is a variation of the traditional BPK model where only the verifier is assumed to hold public keys. In the original BPK model, under the sub-exponential hardness assumption of factoring, we construct a 2-round simultaneously resettable sound resettable $$(T,\epsilon )$$

(
T
,
ϵ
)

-zero knowledge protocol for $$\textsf{NP}$$
NP
.
MS brain health quality standards: a survey on the reality in clinical practice in Germany
Authors: Voigt Isabel , Akgün Katja , Inojosa Hernan , Haas Judith , Temmes Herbert , Meuth Sven G. , Giovannoni Gavin , Ziemssen Tjalf 
Published: November 2024

Abstract
Background
The quality of treatment is especially critical in the context of complex and chronic diseases such as multiple sclerosis (MS). The Brain Health Initiative, an independent international consortium of neurologists, reached a consensus on time-based quality standards prioritizing brain health-focused care for people with MS.

Objectives
To gain deeper insights into the transferability of these quality standards to a specific area, we conducted a survey among MS experts across various MS centers in Germany.

Methods
Participants were asked about time frames considered high standards and those currently being implemented in daily routine based on their experience.

Results
The results reveal a large gap between ideal conceptions and their adaptation in the real world, mostly due to a lack of resources.

Conclusions
Nevertheless, these guidelines and recommendations can be aspired to as ideals. Consensual and inclusive clinical pathways complemented by measurable quality indicators are needed to improve care and approach these ideals. Neither exists in the current management of MS.
Development and validation of an Arabic tool for assessment of post-vaccination confidence in COVID-19 vaccines (ARAB-VAX-CONF)
Authors: Abuyadek Rowan , ElHafeez Samar Abd , Tahoun Mohamed Mostafa , Othman Sally Samir , Omran Abdelrahman , Fathy Naglaa , Ghazy Ramy Mohamed 
Published: November 2024

Abstract

Background
Vaccine confidence is described as a belief that vaccines are effective, safe, and part of a trustworthy health system. The objective of this study was to develop and validate an Arabic tool to evaluate confidence in the received coronavirus disease 2019 (COVID-19) vaccines (ARAB-VAX-CONF).

Methods
The research team developed the ARAB-VAX-CONF based on three areas specified by the Centers for Disease Control and Prevention (CDC): confidence in vaccine effectiveness, confidence in vaccine safety, and confidence in the healthcare system. The analysis includes data from 406 eligible vaccinated persons (≥ 18 years). Cronbach’s alpha was used to measure internal consistency, while convergent, discriminant, exploratory, and confirmatory factor analyses were used to verify construct validity.

Results
A total of 406 adults were recruited, with a mean age of 33.0 ± 12.2 years. A total of 63.1% were males, 56.7% were married, 21.9% had chronic conditions, 93.3% were nonsmokers, and 39.6% were obligated to obtain vaccines. The three domains of the scale met the criterion of internal consistency (Cronbach’s alpha > 0.7). Convergent validity was identified by the significant inter-item and item-mean score of the domain correlation (P < 0.001). Discriminant validity was reported as the inter-factor correlation matrix (< 0.7). The Kaiser–Meyer–Olkin sampling adequacy measure was 0.80, and Bartlett’s sphericity test was significant (P < 0.001). Exploratory factor analysis indicated that the scale could be summarized into three factors. Confirmatory factor analysis confirmed the adequate psychometric properties and fit with observed data (root-mean-square error of approximation = 0.08, comparative fit index = 0.945, Tucker-Lewis index = 0.924, standardized root-mean-square residual = 0.086, normed fit index = 0.918, and goodness-of-fit index = 0.909).

Conclusions
The ARAB-VAX-CONF developed in this study is valid and reliable for assessing confidence in vaccine effectiveness, safety, and confidence in the healthcare system. The ARAB-VAX-CONF can support decision-makers in addressing the gap in vaccine confidence among various populations.
Adrenal Disorders in Pregnancy. A Comprehensive Review and Prospects for Future Research
Authors: Filipek Kinga , Zalewska Natalia , Skiekowski Bartosz , Mugała Waldemar , Mrugała Sebastian , Muciek Michał , Kawka Jakub , Czyżewski Filip , Baranowska Katarzyna , Baranowska Alicja 
Published: November 2024

Introduction and purpose: Adrenal disorders cover a spectrum of conditions, including adrenal insufficiency, Cushing's syndrome and others. Each disorder has its own implications for pregnancy and requires an individualised approach. This review aims to provide a comprehensive overview of adrenal disorders during pregnancy, such as endogenous Cushing's syndrome, adrenal insufficiency, primary aldosteronism, and pheochromocytoma.
Brief description of the state of knowledge: During pregnancy, a number of adaptive processes take place in a woman's body including changes in the endocrine system. Given all these changes, adrenal diseases pose both diagnostic and therapeutic challenges. The symptoms of adrenal diseases often overlap with those observed during physiological pregnancy. Adrenal disorders during pregnancy if unrecognised or treated inadequately, can lead to negative consequences for the mother and foetus, indicating the importance of awareness of these conditions among physicians.
Conclusions: Treating and diagnosing adrenal diseases during pregnancy is a major challenge for doctors. It is crucial to diagnose adrenal diseases in pregnant women as early as possible, and to meticulously plan pregnancies for women diagnosed before conception to prevent the negative consequences of untreated adrenal disorders. Optimal control of treatment before conception should be sought. Access to specialised centres with multidisciplinary teams experienced in treating these conditions is crucial for optimal maternal and foetal care.
The Association between Allergies and Hematologic Tumors — A Review
Authors: Hrapkowicz Aleksandra , Szydziak Joanna , Janowska Kinga , Szeidl Olga , Rehan Dominika , Wołoszczak Julia , Mioskowska  Agnieszka , Dąbkowska Daria 
Published: November 2024

Introduction: Dysfunctions of the immune system in allergic diseases and hematological malignancies are the subject of many studies due to the mechanisms that link them. Chronic inflammation created in the immune response in an allergic reaction has been associated with developing neoplastic diseases.
Aim of the study: This review examines the potential correlation between Allergies and Hematologic Tumors: acute lymphoblastic leukemia, childhood leukemias, non-Hodgkin and Hodgkin lymphomas.
Material and methods: An English-language literature review was conducted, analyzing studies from the PubMed database up to October 2024 regarding the correlation between Allergies and Hematologic Tumors. The review was performed using the PubMed database, with 50 works used.
Conclusions: The relationship between allergies and hematological tumors is unclear. According to some studies, this relationship does not exist; some state, however, that allergic diseases show correlations with hematological malignancies. The results of these studies do not provide a clear answer to whether this is a positive or negative relationship. Some studies suggest that allergies reduce the risk of hematological malignancies, while others contradict this, suggesting that allergies may increase the risk of hematological tumors. The results of studies showing an increased risk of hematological malignancies in people suffering from allergies can be due to the hypothesis of antigenic stimulation, which may explain the mechanism of correlation between those diseases. This hypothesis suggests that chronic immune stimulation predisposes to hematologic malignancies such as multiple myeloma, non-Hodgkin's lymphoma (NHL), and leukemia by promoting the development of randomly occurring pro-oncogenic mutations in actively dividing immune cells. Different results on this potential correlation showed that further studies are necessary.
Interrelationships between affective disorders in the form of depression and obesity and overweight - A systematic review
Authors: Marczak Aleksandra , Krawczuk vel Walczuk Julia , Maciąg Maria , Sobczyk Maciej , Garbacz Karolina , Pasztelan Małgorzata , Pulikowski Jarosław , Muca Aleksandra , Słaboń Małgorzata , Baran Joanna 
Published: November 2024

Both depression and obesity are significant health, social and economic problems.
Depressive disorders were the second most common psychiatric disorder in 2017 after anxiety disorders. According to data published by the World Health Organization (WHO), depression affects about 280 million people worldwide, which is about 3.8 percent of the population. The etiology of depressive disorders is very complex and still not fully understood. The theories described so far complement each other. The factors underlying the development of depressive disorders can be divided into biological, psychological and other factors. Eating disorders in the form of overweight and obesity result from a loss of balance between anabolic and catabolic processes. This is most often led by insufficient physical activity and excess caloric intake. Hormonal disorders, genetic factors and environmental factors may also play an important role in the pathogenesis of obesity. The steadily increasing number of people suffering from depression and obesity prompts the search for links between these two seemingly unrelated disease entities. According to current knowledge, these diseases are bi-directionally linked by genetic, psychological, metabolic and social factors. Depression is associated with an increase in the risk of obesity by about 37% relative to those without depression. Obesity is associated with an increase in the risk of depressive disorders by about 18%. Understanding the links that exist between depressive disorders and obesity enables the search for new therapeutic options. The most important conclusion from the scientific research conducted so far is the advantage of simultaneous treatment of obesity and depression over treating these disease entities individually.
Oral Health Complications of SCUBA Diving
Authors: Sionek-Wręga Irena , Wręga Jakub 
Published: November 2024

OBJECTIVE
This review aims to assess the specific oral health complications associated with SCUBA diving, including barodontalgia, barosinusitis, and temporomandibular joint (TMJ) disorders, and to examine the dental implications of hyperbaric oxygen therapy (HBOT) used in decompression sickness treatment. Additionally, this review identifies gaps in the literature and suggests areas for further research to improve dental care guidelines for divers.

MATERIALS AND METHODS
A systematic literature search was conducted using PubMed and Scopus databases from 2004 to 2024, focusing on terms such as "barodontalgia," "dental barotrauma," and "diving dentistry." From 77 initial articles, 25 studies were selected based on relevance to pressure-induced oral complications, diving-related barotrauma, and dental management for SCUBA divers.

RESULTS
The review identifies barodontalgia as a prevalent issue, commonly triggered by untreated caries or defective restorations, with symptoms intensified by pressure changes. TMJ disorders, linked to prolonged clenching on diving mouthpieces, and sinus-related barotrauma also emerged as significant concerns. Preventive measures, including regular dental checkups, use of resin-based cements, and customized mouthpieces, are recommended to reduce risks. Furthermore, the review highlights a need for larger, controlled studies across diverse diver populations to validate current recommendations and develop accessible guidelines, especially for recreational divers who may lack access to specialized dental care.
Artificial Intelligence in Emergency Medicine: A Literature Review
Authors: Sitarek Gracjan , Żerek Marta 
Published: November 2024

IntroductionArtificial intelligence (AI) is rapidly transforming medical fields, particularly emergency medicine (EM), where timely decision-making is crucial. AI offers potential benefits in diagnostic accuracy, patient care optimization, and workflow efficiency within emergency departments (EDs).
Purpose of WorkThis review aims to synthesize recent advancements in AI applications within emergency medicine, focusing on diagnostic support, patient triage, clinical decision support systems (CDSS), and workflow optimization. Additionally, we highlight the potential benefits, challenges, and future directions for AI in EM.
Material and MethodsA comprehensive literature search was conducted using PubMed and Google Scholar databases. We reviewed peer-reviewed articles from 2008 to 2024, focusing on AI-driven solutions in EDs. Keywords included "artificial intelligence," "emergency medicine," "machine learning," and "clinical decision support." Studies were selected based on their relevance to AI applications in EM, diagnostic improvements, and operational efficiency.
The results highlight the promising role of AI in improving diagnostic accuracy, reducing overcrowding, optimizing triage processes, and addressing clinician workload. However, challenges like ethical concerns, data bias, and the need for clinical validation remain. Further research is necessary to integrate AI more effectively in clinical practice.