bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐related quality of life in patients with chronic myeloid leukemia receiving first‐line therapy with nilotinib
Authors: Efficace Fabio , Castagnetti Fausto , Martino Bruno , Breccia Massimo , D'Adda Mariella , Angelucci Emanuele , Stagno Fabio , Cottone Francesco , Malato Alessandra , Trabacchi Elena , Capalbo Silvana Franca , Gobbi Marco , Visani Giuseppe , Salvucci Marzia , Capodanno Isabella , Tosi Patrizia , Tiribelli Mario , Scortechini Anna Rita , Levato Luciano , Maino Elena , Binotto Gianni , Gugliotta Gabriele , Vignetti Marco , Baccarani Michele , Rosti Gianantonio 
Published: March 2018

BACKGROUNDAlthough a wealth of efficacy and safety data is available for many tyrosine kinase inhibitors used in chronic myeloid leukemia (CML), there is a dearth of information on their impact on patients' health‐related quality of life (HRQOL). The primary objective of this study was to evaluate HRQOL and fatigue outcomes in patients with CML receiving first‐line therapy with nilotinib.METHODSThis was a multicenter, prospective study enrolling 130 patients with chronic‐phase CML. HRQOL and fatigue were evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐C30) and its validated Fatigue module at the baseline and then at 3, 6, 12, 18, and 24 months. The primary prespecified HRQOL endpoints defined in the study protocol for longitudinal analysis were the Physical Functioning, Social Functioning, Role Functioning, and Fatigue scales. The remaining scales were investigated on an exploratory basis.RESULTSThe rate of baseline compliance with the HRQOL assessment was 95.4% (124 of 130), and the rate of overall compliance with HRQOL forms was 91%. Among the 4 prespecified primary HRQOL endpoints, statistically significant improvements over time were found for Physical Functioning (P = .013), Role Functioning (P = .004), and Fatigue (P < .001). Clinically meaningful improvements were found already 3 months after the treatment start. The baseline patient self‐reported fatigue severity was an independent predictive factor for the achievement of a major molecular response with an odds ratio of 0.960 (95% confidence interval, 0.934‐0.988; P = .005).CONCLUSIONSFor most patients, HRQOL improvements with nilotinib occur during the early phase of therapy and are maintained over time. Also, a more systematic HRQOL evaluation during the diagnostic workup of CML may help to predict clinical outcomes. Cancer 2018;124:2228‐37. © 2018 American Cancer Society.
Programmed death ligand 1 testing in non–small cell lung carcinoma cytology cell block and aspirate smear preparations
Authors: Noll Bryce , Wang Wei‐Lien , Gong Yun , Zhao Jun , Kalhor Neda , Prieto Victor , Staerkel Gregg , Roy‐Chowdhuri Sinchita 
Published: March 2018

BACKGROUNDImmune checkpoint inhibitors targeting the programmed cell death 1 (PD‐1) receptor and its ligand, programmed death ligand 1 (PD‐L1), have emerged as a therapeutic approach for patients with non–small cell lung carcinoma (NSCLC). PD‐L1 expression, assessed by immunohistochemistry (IHC), is used to select patients for PD‐1/PD‐L1 inhibitor therapy. Most studies have been performed with histology specimens, with limited data available on the performance in cytology specimens. This study evaluated PD‐L1 in cytology specimens and compared the results with those from paired core‐needle biopsy for concordance.METHODSForty‐one NSCLC fine‐needle aspiration cases that had paired core‐needle biopsy specimens with PD‐L1 IHC were selected. A Papanicolaou‐stained direct smear and a cell block section from each case were stained with a Dako PD‐L1 pharmDx antibody (clone 22C3). Only slides with 100 or more tumor cells (37 smears and 38 cell blocks) were evaluated. Tumor proportion scores (TPS) were assessed on the basis of the partial/complete membranous staining of tumor cells and were correlated with those of paired core‐needle biopsy.RESULTSAll 9 smears that were negative for PD‐L1 staining showed 100% concordance with the paired core‐needle biopsy, whereas 28 smears with PD‐L1 expression showed a similar TPS, except for 1 smear that was discordant. In contrast, 10 negative paired core‐needle biopsy cases corresponded to 9 concordant negative cell blocks, whereas 1 cell block had a TPS of 1% to 5%. The remaining 28 cell blocks demonstrated PD‐L1 expression, with 22 cases showing a TPS similar to that of the paired core‐needle biopsy, whereas 6 cell blocks were discordant, likely because of intratumoral heterogeneity.CONCLUSIONSThe results show that NSCLC cytology samples evaluated for PD‐L1 have high concordance with paired core‐needle biopsy samples and can be used for assessing PD‐L1 expression. Cancer Cytopathol 2018;126:342‐52. © 2018 American Cancer Society.
The structure identification of a diphenhydramine‐related impurity in methamphetamine
Authors: Liu Cuimei , Jia Wei , Han Yu , Hua Zhendong 
Published: March 2018

AbstractSome methamphetamine (MA) crystals contain pharmaceutical impurities resulting from the co‐ingredients of medicines used for extracting ephedrine/pseudoephedrine. These pharmaceutical impurities and their related byproducts can reflect the trends in precursor chemicals and manufacturing sources. In this research, 1 pharmaceutical‐impurity‐related byproduct was detected in several seized MA samples synthesized by I/P (Nagai, Moscow, or Hypo) method. Its structure was postulated through the analysis of fragment ions in electron ionization (EI) mass spectrum. The impurity was further synthesized and analyzed using electrospray ionization–collision‐induced dissociation (ESI–CID) mass spectrum and nuclear magnetic resonance (NMR), and finally determined to be N1,N1,N2‐trimethyl‐N2‐(1‐phenylpropan‐2‐yl)ethane‐1,2‐diamine. The impurity was inferred to be generated by the reaction of MA and the breakdown of diphenhydramine, a co‐ingredient of medicines used for extracting ephedrine/pseudoephedrine. Simulation MA synthetic experiments via Nagai, Moscow, and Hypo methods using ephedrine and diphenhydramine as starting materials were performed to prove our presumption. The presence of the impurity indicates that these MA samples were manufactured from pharmaceutical containing ephedrine/pseudoephedrine and diphenhydramine.
Comparing men and women with binge‐eating disorder and co‐morbid obesity
Authors: Lydecker Janet A. , Grilo Carlos M. 
Published: March 2018

AbstractObjectiveThis study examined differences in clinical presentation of men and women with binge‐eating disorder (BED) who participated in treatment research at a medical‐school based program.MethodParticipants were 682 adults (n = 182 men, n = 500 women) with DSM‐IV‐defined BED. Doctoral‐level research clinicians assessed eating‐disorder psychopathology, including BED diagnosis, using the Structured Clinical Interview for DSM‐IV Disorders (SCID) and Eating Disorder Examination (EDE) interview. Research clinicians measured height and weight and participants completed a battery of established self‐report measures.ResultsMen had significantly higher body mass index (BMI) than women; women had significantly higher eating‐disorder psychopathology (EDE scales and global score) and depression than men. Differences in eating‐disorder psychopathology and depression remained higher for women than men after adjusting for race/ethnicity and BMI. Frequency of binge‐eating episodes, subjective binge‐eating episodes, and overeating episodes did not differ significantly by sex. Women had younger ages of onset for dieting and binge‐eating behaviors than men but ages of onset for obesity and BED did not significantly differ between men and women.DiscussionThere are some sex differences in clinical presentation and age‐of‐onset timeline of adults with BED. Men and women develop obesity and BED (at diagnostic threshold) around the same age but women begin dieting and binge‐eating behaviors earlier than men. At presentation for treatment for BED, men and women did not differ in binge‐eating frequency and although men and women differed significantly on BMI and eating‐disorder psychopathology, the magnitude of these differences was quite modest.
Baseline diastolic pressure gradient and pressure reduction in chronic heart failure patients implanted with the CardioMEMS™ HF sensor
Authors: Wolfson Aaron M. , Grazette Luanda , Saxon Leslie , Nazeer Haider , Shavelle David M. , Jermyn Rita 
Published: March 2018

AbstractAimsRemote haemodynamic monitoring (RHM) decreases hospitalization rates in patients with chronic heart failure (HF). Many patients with chronic HF develop pulmonary hypertension (PH) secondary to left heart disease with some acquiring combined pre‐capillary and post‐capillary PH (Cpc‐PH). The efficacy of RHM in achieving pulmonary pressure reductions in patients with Cpc‐PH vs. isolated post‐capillary PH (Ipc‐PH) is unknown. The purpose of this study is to evaluate whether a higher baseline diastolic pressure gradient (DPGbaseline) measured at the time of CardioMEMS™ HF sensor implantation is associated with lower reductions in pulmonary artery diastolic pressures (PADP).Methods and resultsThis was a retrospective analysis of 32 patients meeting clinical indications for CardioMEMS™ implantation. DPGbaseline categorized patients as Cpc‐PH (DPG ≥ 7 mmHg) or Ipc‐PH (DPG < 7 mmHg). Minimum achievable PADP (PADPmin) and ∆PADP (PADPbaseline − PADPmin) were determined. Pearson's correlation analysis and comparison of mean pressure changes were assessed. Median age was 69 years, and median left ventricular ejection fraction (LVEF) was 25%. Eight patients (25%) had a LVEF ≥40%. Twenty‐five patients (78%) met criteria for Ipc‐PH and seven (22%) for Cpc‐PH. Neither PADPmin (ρ = 0.27; P = 0.13) nor ΔPADP (ρ = 0.07; P = 0.72) was correlated with DPGbaseline. A trend towards higher ΔPADP was seen in Cpc‐PH vs. Ipc‐PH patients (15.2 vs. 9.88 mmHg; P = 0.12). There was a moderate positive correlation between baseline PADP and ΔPADP [ρ = 0.55 (0.26–0.76); P < 0.001].ConclusionsDecreased PADP reduction was not seen in Cpc‐PH vs. Ipc‐PH patients. Higher PADPbaseline was associated with greater ΔPADP. Larger studies are needed to elaborate our findings.
Synthesis, Structure, and Magnetic Properties of a Family of Complexes Containing a {CoII2DyIII} Pivalate Core and a Pentanuclear CoII4DyIII Derivative
Authors: Kiskin Mikhail , Zorina‐Tikhonova Ekaterina , Kolotilov Sergey , Goloveshkin Alexander , Romanenko Galina , Efimov Nikolay , Eremenko Igor 
Published: March 2018

AbstractInvited for the cover of this issue is research led by Mikhail Kiskin from the Russian Academy of Sciences, Moscow, Russian Federation, in collaboration with the National Academy of Sciences of Ukraine, Kiev, Ukraine. The cover image shows the synthesis, structure, and magnetic properties of a family of complexes containing a Co2Dy trinuclear core.
Telephone‐based management of chronic pain in older adults in an integrated care program
Authors: Helstrom Amy , Haratz Josh , Chen Shirley , Benson Amy , Streim Joel , Oslin David 
Published: March 2018

ObjectiveFew studies have explored behavioral strategies for managing chronic pain in older adults. Pain Care Management (PCM) is a telephone‐based behavioral intervention for chronic pain. The present study examined chronic pain characteristics among older adults and tested the delivery of PCM as an adjunct to depression and anxiety care management.MethodsParticipants were drawn from a state‐sponsored program offering care management services to community members aged 65 and older who were prescribed a psychotropic medication by a primary care provider. Chronic pain information was collected for all participants in the state program (N = 250) and treatment outcome data were collected for a subset with significant chronic pain. Eighty participants with high chronic pain interference were offered PCM and compared to 80 participants with chronic pain who received monitoring only on depression, anxiety, and pain interference outcomes.ResultsChronic pain was identified in 14% of older adults newly prescribed a psychotropic medication. Compared to monitoring only, PCM participants had higher odds of seeing a reduction of 2 or more points in pain interference at 6 months. Pain care management participants' anxiety scores significantly decreased over the study period.ConclusionsOlder adults treated with psychotropic medications often also experience chronic pain that interferes with daily activities. A telephone‐based care management intervention is acceptable and feasible with an older community‐based population and can lead to improvements in anxiety symptoms and interference from chronic pain. Further research will help to refine interventions that may help improve symptoms and increase functioning with this population.
The neural correlates of morphological complexity processing: Detecting structure in pseudowords
Authors: Schuster Swetlana , Scharinger Mathias , Brooks Colin , Lahiri Aditi , Hartwigsen Gesa 
Published: March 2018

AbstractMorphological complexity is a highly debated issue in visual word recognition. Previous neuroimaging studies have shown that speakers are sensitive to degrees of morphological complexity. Two‐step derived complex words (bridging through bridgeN > bridgeV > bridging) led to more enhanced activation in the left inferior frontal gyrus than their 1‐step derived counterparts (running through runV > running). However, it remains unclear whether sensitivity to degrees of morphological complexity extends to pseudowords. If this were the case, it would indicate that abstract knowledge of morphological structure is independent of lexicality. We addressed this question by investigating the processing of two sets of pseudowords in German. Both sets contained morphologically viable two‐step derived pseudowords differing in the number of derivational steps required to access an existing lexical representation and therefore the degree of structural analysis expected during processing. Using a 2 × 2 factorial design, we found lexicality effects to be distinct from processing signatures relating to structural analysis in pseudowords. Semantically‐driven processes such as lexical search showed a more frontal distribution while combinatorial processes related to structural analysis engaged more parietal parts of the network. Specifically, more complex pseudowords showed increased activation in parietal regions (right superior parietal lobe and left precuneus) relative to pseudowords that required less structural analysis to arrive at an existing lexical representation. As the two sets were matched on cohort size and surface form, these results highlight the role of internal levels of morphological structure even in forms that do not possess a lexical representation.
Noninvasive extraction of microsecond‐scale dynamics from human motor cortex
Authors: Koponen Lari M. , Nieminen Jaakko O. , Mutanen Tuomas P. , Ilmoniemi Risto J. 
Published: March 2018

AbstractState‐of‐the‐art noninvasive electromagnetic recording techniques allow observing neuronal dynamics down to the millisecond scale. Direct measurement of faster events has been limited to in vitro or invasive recordings. To overcome this limitation, we introduce a new paradigm for transcranial magnetic stimulation. We adjusted the stimulation waveform on the microsecond scale, by varying the duration between the positive and negative phase of the induced electric field, and studied corresponding changes in the elicited motor responses. The magnitude of the electric field needed for given motor‐evoked potential amplitude decreased exponentially as a function of this duration with a time constant of 17 µs. Our indirect noninvasive measurement paradigm allows studying neuronal kinetics on the microsecond scale in vivo.
Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage
Authors: Luo Weijian , Wang Hao , Hu Jiliang 
Published: March 2018

ObjectiveTo explore the role of serum periostin in patients with aneurysmal subarachnoid hemorrhage (aSAH).MethodWe conducted a retrospective study and 124 aSAH patients treated in Shenzhen People's hospital during March 1st 2015 to December 30th 2016 were included. Baseline information, neurological status and clinical outcome were recorded. Blood samples on admission were collected and enzyme linked immunosorbent assay (ELISA) kits were used to detect the serum level of periostin. Spearman's Correlation Analysis was used to analyze the correlation between periostin and clinical severity. Receiver operating characteristic (ROC) curve was performed to investigate variables’ prognostic value in patients with aSAH.ResultsThe average age of patients included was 57.23 years old. Preliminary analysis revealed that serum periostin was significantly correlated with clinical severity. Patients with poor outcome at 12 months had higher level of periostin than patients with good outcome. Multivariate logistic regression analysis showed elevated level of periostin was significantly associated with poor outcome and the AUC was 0.85 for periostin in predicting poor outcome of patient with aSAH.ConclusionElevated serum periostin concentrations are significantly associated with clinical severity and poor outcome of aSAH patients, which indicate serum periostin can be used as a prognostic biomarker in patients with aSAH.
Temporary and Permanent Effects of Remittances on Economic Growth in Ecuador
Authors: Pontarollo Nicola , Mendieta Muñoz Rodrigo 
Published: March 2018

AbstractThis article analyses the temporary and permanent effects of remittances on subnational economic growth in Ecuador. We find that both effects are statistically significant. However, while the size of first is negligible, the magnitude of the permanent effect is inversely related to the stage of development. Copyright © 2018 John Wiley & Sons, Ltd.
In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy
Authors: Bhattacharjee Tanmoy , Fontana Leticia C. , Raniero Leandro , Ferreira‐Strixino Juliana 
Published: March 2018

AbstractBreast cancer is most fatal cancer among women worldwide. The high mortality can be attributed to late detection and low treatment efficacy. Treatment is difficult owing to the multitude of breast cancer subtypes and making decisions on therapeutic strategy difficult. A tool to predict treatment prognosis may greatly aid this decision making. Currently available prediction methods have low accuracy in addition to several other disadvantages. Of the several new techniques being investigated for prognosis prediction, Raman spectroscopy (RS) has the advantage of high sensitivity, rapidity, and amenability to in vivo applications, making it ideal for clinical translation. In this study, we have evaluated the biochemical changes posttherapy with respect to pretherapy using RS. In vivo Raman spectra acquired from live rat breast tumors (skin removed) without treatment, 24 hr postphotosensitizer injection and 24 hr after photodynamic therapy, were analyzed using multivariate principal component—linear discriminant analysis. Relative increase in some spectral signatures associated with nucleic acids, amino acids, and proteins, especially collagen, were observed posttherapy; and pretherapy and posttherapy spectra could be classified with 100% efficiency. The ability of RS to detect these changes suggests possibility of deciphering spectral markers for prognostic applications in future.
Spatial differences in dissolved silicon utilization in Lake Baikal, Siberia: Examining the impact of high diatom biomass events and eutrophication
Authors: Panizzo V. N. , Roberts S. , Swann G. E. A. , McGowan S. , Mackay A. W. , Vologina E. , Pashley V. , Horstwood M. S. A. 
Published: March 2018

AbstractRecent research has highlighted how Lake Baikal, Siberia, has responded to the direct and indirect effects of climate change (e.g., ice‐cover duration), nutrient loading, and pollution, manifesting as changes in phytoplankton/zooplankton populations, community structure, and seasonal succession. Here, we combine and compare analyses of chlorophyll a (an estimate of total algal biomass), carotenoid pigments (biomarkers of algal groups), and lake water silicon isotope geochemistry (δ30SiDSi) to differentiate spatial patterns in dissolved silicon (DSi) uptake at Lake Baikal. A total of 15 sites across the three basins (south, central, and north) of Lake Baikal were sampled in August 2013 along a depth gradient of 0–180 m. Strong, significant correlations were found between vertical profiles of photic zone DSi concentrations and δ30SiDSi compositions (r = −0.81, p < 0.001), although these are strongest in the central basin aphotic zone (r = −0.98, p < 0.001). Data refute the hypothesis of DSi uptake by picocyanobacteria. Algal biomass profiles and high surface δ30SiDSi compositions suggest greater productivity in the south basin and more oligotrophic conditions in the north basin. δ30SiDSi signatures are highest at depth (20 m) in central basin sites, indicating greater (10–40%) DSi utilization at deep chlorophyll maxima. DSi limitation occurs in the pelagic central basin, probably reflecting a high diatom biomass bloom event (Aulacoseira baicalensis). Meanwhile in the more hydrologically restricted, shallow Maloe More region (central basin), both high δ30SiDSi compositions and picocyanobacteria (zeaxanthin) concentrations, respectively point to the legacy of an “Aulacoseira bloom year” and continuous nutrient supply in summer months (e.g., localized eutrophication).
Gastric inhibitory polypeptide receptor antagonist, SKL‐14959, suppressed body weight gain on diet‐induced obesity mice
Authors: Nakamura T. , Tanimoto H. , Mizuno Y. , Okamoto M. , Takeuchi M. , Tsubamoto Y. , Noda H. 
Published: March 2018

SummaryObjectiveGastric inhibitory polypeptide plays a role in glucose and lipid metabolism and is associated with obesity and insulin resistance. The objective of this study is to confirm the anti‐obesity effects of the gastric inhibitory polypeptide receptor antagonist, SKL‐14959, on diet‐induced obesity mice.MethodDiet‐induced obesity mice at 20 weeks of age were administered with or without SKL‐14959 for 96 d. Body weight and food intake were monitored throughout the experiment. Mice were sacrificed, and physiological and biochemical markers were measured, and then histochemical and gene expression analyses were also performed. In further studies, mice were orally gavaged with [14C]‐oleic acid to investigate the excursion of digested lipids.ResultsSKL‐14959 significantly suppressed weight gain without affecting food intake, decreased triacylglycerol contents in the liver and the muscle and the intensity stained with oil‐red in the liver. It also improved plasma glutamic pyruvic transaminase and 3‐hydroxybutyrate levels in addition to notably down‐regulated relative gene expression of srebf1 and dgat1 in the liver despite not altering in the adipose tissue. Furthermore, SKL‐14959 showed remarkable inhibition of lipid uptake in the adipose tissue after the oil challenge.ConclusionSKL‐14959 inhibited lipids uptake and improved lipids metabolism, results in suppression of body‐weight gain.