bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Bilateral, Recurrent, Late-onset Diffuse Lamellar Keratitis After LASIK in a Patient With Cogan's Syndrome
Authors: Javaloy Jaime , Barrera Carlos , Muñoz Gonzalo , Pérez-Santonja Juan J. , Vidal María T. , Alió Jorge L. 
Published: February 2019

Purpose
To report a patient with severe and progressive bilateral deafness who suffered recurrent episodes of diffuse lamellar keratitis (DLK) in both eyes ⩾4 months after undergoing uneventful LASIK for myopia.

Methods
Four months after LASIK, the patient presented with blurred vision in the left eye. Best spectacle-corrected visual acuity was 0.9. Slit-lamp examination revealed aggregates of white cells at the paracentral and mid-peripheral interface without affecting the visual axis. Diffuse lamellar keratitis stage II was diagnosed and intensive corticosteroid treatment was started. Uncorrected visual acuity (UCVA) in the right eye was 1.2 with no signs of DLK.

Results
One week after initiating corticosteroid treatment, UCVA improved (1.2) in the left eye. Diffuse lamellar keratitis was diagnosed in the left eye again at 9 months and in the right eye at 15 months after LASIK. The patient was later diagnosed with atypical Cogan's syndrome.

Conclusions

Recurrent and late-onset DLK may be due to other patient systemic conditions predisposing to interstitial keratitis, such as Cogan's syndrome. [
J Refract Surg.
2008;24:548–550.]
Microbial Keratitis After INTACS Implantation With Loose Suture
Authors: Hashemi Hasan , Ghaffari Reza , Mohammadi Masood , Moghimi Sasan , Miraftaab Mohammad 
Published: February 2019

Purpose
To report a case of rapidly progressive infectious keratitis after INTACS implantation for keratoconus.

Methods
A 32-year-old man presented with pain and decreased vision in the right eye of 2 days' duration. Right eye visual acuity was 20/800. He had undergone bilateral INTACS implantation 40 days prior for treatment of keratoconus.

Results

Slit-lamp examination revealed corneal ulceration and loose suture. The corneal ulcer progressed despite aggressive therapy, and the patient underwent penetrating keratoplasty 48 hours after admission. The culture from corneal scraping and corneal button was positive for
Staphylococcus aureus
.

Conclusions

Infectious keratitis is a rare but devastating complication of INTACS implantation for treatment of keratoconus. Meticulous wound closure is necessary to reduce the risk of infection, especially in eyes with irregular corneal contour and variable corneal thickness. [
J Refract Surg.
2008;24:551–552.]
Early Surface Ablation on Aborted LASIK Flaps
Authors: Brenner Jason E. , Mohinani Ajay B. , Janbatian Hrag Y. , Melki Samir 
Published: February 2019

PURPOSE:To report the outcomes of a series of 16 patients who had secondary surface ablation within 4 weeks of an aborted femtosecond laser–assisted in situ keratomileusis (FS-LASIK) procedure.METHODS:A retrospective chart review of electronic medical record data from 2011 to 2015 was performed to identify eyes of patients who had an aborted FS-LASIK procedure followed by secondary surface ablation (photorefractive keratectomy or laser epithelial keratomileusis) within 4 weeks of the primary procedure. Patients were required to have at least three postoperative visits to be included in the study.RESULTS:The review identified 20 aborted FS-LASIK procedures of 7,142 eyes (0.003%), of which 16 met the inclusion criteria. The most common reasons for abortion were incomplete (10) and decentered (3) flaps. Thirteen of 16 eyes were treated within 2 weeks. A total of 11 of 16 eyes achieved uncorrected distance visual acuity (UDVA) of 20/20, 13 of 16 achieved UDVA of 20/25 or better, and 15 of 16 had a corrected distance visual acuity (CDVA) of 20/20. There were no intraoperative complications during the second procedure and there were no cases of diffuse lamellar keratitis. One patient developed postoperative haze with a CDVA of 20/25 and was lost to follow-up.CONCLUSIONS:This case series indicates that early surface ablation (within 4 weeks) after an aborted FS-LASIK procedure may be performed with good visual outcomes.[J Refract Surg. 2019;35(2):121–125.]
Multiscale Habitat Selection of Lesser Prairie-Chickens in a Row-Crop and Conservation Reserve Program Land Matrix
Authors: Harryman Samuel W.H. , Grisham Blake A. , Boal Clint W. , Kahl Samantha S. , Martin Russell L. , Hagen Christian A. 
Published: February 2019

Abstract
The lesser prairie-chicken Tympanuchus pallidicinctus has received considerable attention in recent years, as a result of population decline and the uncertainty of its status under the 1973 U.S. Endangered Species Act. Substantial effort has been exerted studying the life history of the species and effects of some management practices on its ecology. However, information is lacking regarding lesser prairie-chicken use and selection of Conservation Reserve Program fields in the Southern High Plains of Texas. To fill in this knowledge gap, we assessed habitat selection by lesser prairie-chickens within Conservation Reserve Program fields, native grassland, and row-crop agriculture in Texas, 2015–2017. We assessed habitat selection using a Type II design at the second order of selection (home range placement within the landscape) and a Type III design at the third order (Global Positioning System locations within the home range). At the second order of selection, lesser prairie-chickens selected Conservation Reserve Program fields seeded in nonnative grasses (wi = 3.99, 95% CI = 1.60–6.39) and native grasses and forbs (wi = 3.25, 95% CI = 1.99–4.52) year-round. Row-crop agriculture (wi = 0.17, 95% CI = 0.06–0.28) and native grassland (wi = 0.30, 95% CI = 0.06–0.55) were avoided. Native grass Conservation Reserve Program fields were used in proportion to their availability (wi = 1.33, 95% CI = 0.81–1.85) year-round. Only Conservation Reserve Program fields seeded in native grasses and forbs were selected at the third order of selection (wi = 1.32, 95% CI = 1.16–1.47). Based on our results, Conservation Reserve Program fields provide habitat for lesser prairie-chickens, and as such, may be beneficial to persistence of the species on the High Plains of Texas.
Tracheoesophageal Fistula: Bridging the Gap by Over‑the‑scope Clip Services
Authors: Balekuduru Avinash Bhat , Dhande Siddharth , Venkateshappa Lokesh Locheruvapalli , Subbaraj Satyaprakash Bonthala 
Published: February 2019

AbstractTracheoesophageal fistula (TOF) can be congenital or acquired. Acquired TOF can be caused by iatrogenic or traumatic or due to malignancy with pulmonary infection or aspiration being the presenting symptom. Management of TOF is associated with high mortality and morbidity and remains an interdisciplinary challenge. In general, depending on the size and location of the tracheal aspect of the fistula, surgical therapy involves primary repair of the fistula and, if necessary, resection and reconstruction of the trachea. We present two cases of iatrogenic TOF following surgery successfully closed using over‑the‑scope clips. This report also compares both the Ovesco and Padlock clip devices.
Endoscopic Sleeve Gastroplasty for Obesity – First Indian Experience: Case Series and Review of Literature
Authors: Jagtap Nitin , Kalapala Rakesh , Katakwar Abhishek , Darishetty Santosh , Reddy D Nageshwar 
Published: February 2019

ABSTRACT
Introduction: In India, obesity affects >135 million and leads to nearly 5.8 million deaths per year. Some of the unmet need in the management of obesity can be fulfilled by endoscopic therapies such as endoscopic sleeve gastroplasty (ESG). Methods: In this case series, we report our preliminary experience of ESG in three obese patients. We recorded baseline demographic data, total procedural time, adverse events, and percentage total body weight loss (%TBWL) up to 20 weeks. Results: All three patients were male with a median age of 29 years (range 26–39) with a median body mass index of 34.28 kg/m2 (range 32.60–37.13). A total of four full‑thickness and additional three submucosal sutures were applied in each patient. There were no adverse events. The median total procedural time was 105 min (range 90–150). All patients were discharged within 48 h. The median percentage total body weight loss (%TBWL) at 12 weeks was 12.02 (range 10.85–13.33) and at 16 weeks was 14.23 (range 13.84–14.62). The maximum follow‑up so far is 20 weeks (one patient) with %TBWL of 16.38. Conclusion: In our preliminary experience, we conclude that ESG is safe, effective and requires shorter hospital stay. In short‑term follow‑up, there is adequate weight loss without major adverse events.
A Clinical Study of the Use of Savary‑Gilliard Dilators in Corrosive Esophageal Strictures without the Use of Fluoroscopy: A Reality in Resource‑Limited Settings in a Developing Country
Authors: Bhatt Varsha Rajat , Kakrani Arjun Lal 
Published: February 2019

ABSTRACT
Context: Corrosive compounds are either acids or alkalis, and their ingestion can cause esophageal strictures which may be tortuous and multiple. Aims: The aim of study was to assess therapeutic efficacy and safety of dilatation using Savary‑Gilliard dilators in these patients without the use of fluoroscopy. Settings and Design: A cross‑sectional observational study, conducted for 18 months in a tertiary care teaching hospital in Western India. Subjects and Methods: Ten dysphagic patients who had a history of corrosive ingestion 2 months or more before presentation, who had documented esophageal strictures on endoscopy were included. Barium swallow and endoscopy confirmed the site, length, and number of strictures. Dilatation with Savary‑Gilliard dilators was done without the use of fluoroscopy with the help of guide wire in “rule of threes.” Patients were followed up immediately and for 12 months. Descriptive statistics, mean, and SD were applied in EPI info version 7 software. Results: The mean age of 29 + 6.5 years and 70% were females. About 80% had dysphagia Grades III and IV. On endoscopy, 40% had strictures at multiple sites and 60% of patients had strictures more than 5 cm in length. 50% strictures were very tight. Number of patients in whom there was the passage of one dilator more than the stricture in the first session were 80%. A mean of 8.28 sessions of dilatation were required. Adequate dysphagia relief was achieved in 8 (80%) patients, while there were 2 failures. A total of 180 dilatations were performed on these 10 patients of corrosive strictures over a period of 12 months. One minor perforation occurred in this study. Conclusions: In resource‑limited settings such as India, dilatation without fluoroscopy can be considered as effective and safe initial management for corrosive strictures.
Contribution to the knowledge of early geotechnics during the twentieth century: Ralph Peck
Authors: Lara-Galera Antonio , Galindo-Aires Rubén , Guillán-Llorente Gonzalo 
Published: February 2019

Abstract. Ralph B. Peck (1912–2008), graduate and doctor of philosophy in
civil engineering (1934 and 1937 respectively) from the Rensselaer
Polytechnic Institute, was one of the major contributors to the development
of geotechnics in the twentieth century. Born in Winnipeg (Manitoba) as an
American national, he was influenced from childhood by the world of civil
engineering through his father, Orwin K. Peck, who was a civil engineer,
mainly as a structural engineer in the railway sector. In the absence of job offers as a structural engineer, Ralph Peck arrived at
Harvard University in 1938 to attend the soil mechanics courses taught by
Arthur Casagrande, which guided Peck's professional career towards
geotechnics. In addition to Casagrande, Peck had the opportunity to meet and
work with other very important people related to geotechnics:
Albert E. Cummings, Laurits Bjerrum, Alec W. Skempton and especially
Karl Terzaghi, with whom he established a great friendship, in addition to
providing support, professional advice and performing important work, such as
the Chicago Subway Works. Peck actively dedicated himself to consulting work, which led him to visit
44 states within the United States and 28 countries on five continents. In
addition, he also participated in research work where he was asked and was a
committed lecturer at the University of Illinois, where he was a professor
for 32 years. The objective of this paper is to analyse, through Peck's biography, his
contribution to the field of geotechnics based on his research, teaching and
consultancy work, and through the influence of Peck on other important people
in the field, such as Karl Terzaghi.
Reevaluating Magnetic Resonance Imaging in Radiographically Suspected Osteomyelitis of the Toe
Authors: Ciotola Nicholas , Spielfogel William D. 
Published: February 2019

Background:Magnetic resonance imaging (MRI) is both sensitive and specific in the diagnosis of osteomyelitis, and it is an important imaging modality in preoperative planning of resection of infected bone. In many cases, however, the extent of osseous infection is evident on plain radiographs, and little additional information is gained from the MRI. The goal of this study was to assess the accuracy of radiographs against MRIs in assessing the spread of suspected osteomyelitis from one phalanx to another or to a metatarsal.Methods:A medical record review was performed, and 14 patients with 16 toes confirmed to have osteomyelitis involving one or more phalanges were included in the study. An investigator blinded to the MRI findings interpreted the extent of osseous involvement based solely on the radiographic and clinical presentation. The accuracy of the radiographic interpretation was then calculated against the MRI findings.Results:In 14 of the 16 toes (87.5%), whether osteomyelitis had spread from one bone to another was determined based on the radiographic and clinical presentation. In one toe, the radiograph did not adequately depict osteomyelitis in adjacent infected bone. In one more toe, the radiograph depicted features of osteomyelitis in uninfected bone.Conclusions:In a large percentage of patients, the phalanges affected by osteomyelitis had visible findings on the radiograph, and operative planning could have been based on the radiograph alone.
Safety of Deep Sedation in Patients Undergoing Full-Thickness Skin Graft Harvesting and Skin Graft Reconstruction for Limb Salvage
Authors: Kai Alice M. , Vadivelu Nalini , Dai Feng , Dabu-Bondoc Susan , Mikhael Hosni , Blume Peter A. 
Published: February 2019

Background:Studies on obtaining donor skin graft using intravenous sedation for patients undergoing major foot surgeries in the same operating room visit have not previously been reported. The objective of this retrospective study is to demonstrate that intravenous sedation in this setting is both adequate and safe in patients undergoing skin graft reconstruction of the lower extremities in which donor skin graft is harvested from the same patient in one operating room visit.Methods:Medical records of 79 patients who underwent skin graft reconstruction of the lower extremities by one surgeon at the Yale New Haven Health System between November 1, 2008, and July 31, 2014, were reviewed. The patients' demographic characteristics, American Society of Anesthesiologists class, comorbid conditions, intraoperative analgesic administration, estimated blood loss, total operating room time, total postanesthesia care unit time, and postoperative complications within the first 72 hours were reviewed.Results:This study found minimal blood loss and no postoperative complications, defined as any pulmonary or cardiac events, bleeding, admission to the intensive care unit, or requirement for invasive monitoring, in patients who underwent major foot surgery in conjunction with full-thickness skin graft.Conclusions:We propose that given the short duration and peripheral nature of the procedures, patients can safely undergo skin graft donor harvesting and skin graft reconstruction procedures with intravenous sedation regardless of American Society of Anesthesiologists class in one operating room visit.
The Significance of an MBA Degree for a Podiatric Physician—Is It Worth It?
Authors: Osbourne Abe G. , Johnson Rachel E. , Hinish Carlyn , Ahmed Khatija 
Published: February 2019

Background:The Kent State University College of Podiatric Medicine is negotiating with the College of Business Administration at Kent State University to establish a dual Doctor of Podiatric Medicine (DPM)/Master of Business Administration (MBA) degree. Of the nine colleges of podiatric medicine in the nation, there are two schools that have a joint DPM/MBA program listed in their catalogue, but no joint program was operational at the time this survey was conducted. A telephone survey of the other eight podiatric medical colleges was conducted to obtain that information. This survey was used to assess further data for the exploration of a dual DPM/MBA program at Kent State University College of Podiatric Medicine.Methods:A survey was sent out to 38 individuals who possessed both a DPM and an MBA degree. They responded to questions about why they obtained the business degree, how they are using their business degree, what courses in the MBA program are most relevant, and whether they would recommend that DPM students pursue a dual degree.Results:The majority of respondents indicated that they obtained an MBA degrees to gain a better understanding of the marketplace, to increase their income, and to better manage a podiatric medical practice. The respondents were generally very happy to have obtained their MBA degree and would encourage a dual-degree option. They admitted that a minor or series of courses with a business focus may be helpful to a DPM student who did not opt for an MBA degree.Conclusions:The positive survey results from respondents encourage continued research into a dual-degree DPM/MBA program. During research for a DPM/MBA degree, we feel a DPM with an MBA degree will allow our students to be better prepared for leadership roles within their community and administrative positions and to have a deeper understanding of the business of health care.
ENSINO DE CONTABILIDADE PÚBLICA: UM ESTUDO NO ENSINO SUPERIOR NO ESTADO DE MINAS GERAIS
Authors: Cabral Natielli Pereira Santos , CARVALHO ANDRADE MARIA ELISABETH MOREIRA 
Published: February 2019

<p>Este estudo teve como objetivo, analisar se os conteúdos de ensino do Curso de Ciências Contábeis existentes nas IES do Estado de Minas Gerias, estão alinhados ao proposto pelas Normas Brasileiras Aplicadas ao Setor Público - NBCASP. Para tanto, seguiu-se o modelo proposto por Maciel et al. (2015), com a criação do Índice de Aderência - INBCASP. A amostra foi formada por 32 IES Mineiras com o curso na modalidade presencial, perfazendo um percentual de 47% das IES. A coleta foi de abril a outubro de 2016. Foi utilizada a estatística descritiva e análise das diferenças entre as médias com o uso da Anova. Os resultados revelaram um índice de aderência de 40,9%. Portanto, é preciso uma atualização das IES de Minas Gerais com o objetivo de preparar os discentes para as exigências do mercado de trabalho. Vale ressaltar que mais normas entraram em vigor em janeiro de 2017 e mais uma vez demandará ajustes nas grades curriculares do ensino de Contabilidade Pública.</p>
Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category
Authors: Rumsey Dax G. , Guzman Jaime , Rosenberg Alan M. , Huber Adam M. , Scuccimarri Rosie , Shiff Natalie J. , Bruns Alessandra , Feldman Brian M. , Eurich Dean T. ,   for the Research in Arthritis in Canadian Children Emphasizing Outcomes Investigators
Published: February 2019

ObjectiveTo estimate the impact of enthesitis on patient‐reported outcomes in children with juvenile idiopathic arthritis (JIA), irrespective of JIA category.MethodsChildren enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of Life Questionnaire (JAQQ), Quality of My Life (QoML) Questionnaire, Childhood Health Assessment Questionnaire (C‐HAQ), and a pain visual analog scale were completed at enrollment, every 6 months for 2 years, and then yearly up to 5 years. Analyses consisted of descriptive statistics, linear mixed models for longitudinal data, and analysis of covariance.ResultsAmong 1,371 patients followed for a median of 35.3 months (interquartile range 22.1, 49.2), 214 (16%) had enthesitis, of whom 137 (64%) were classified as having enthesitis‐related arthritis. After adjusting for JIA category and covariates, children with enthesitis reported higher JAQQ (mean raw score 2.71 versus 2.16, adjusted difference 0.41 points; 95% confidence interval [95% CI] 0.22, 0.59), higher C‐HAQ (0.47 versus 0.31, adjusted difference 0.14 points; 95% CI 0.07, 0.22), higher pain (3.01 versus 1.68, adjusted difference 0.94 points; 95% CI 0.64, 1.25), and lower QoML (7.02 versus 8.23, adjusted difference –0.80 points; 95% CI –1.09, –0.51) scores than children without enthesitis. These differences persisted up to 5 years.ConclusionChildren with enthesitis, regardless of JIA category, report worse patient‐reported outcomes than those without enthesitis. Thus, enthesitis should be assessed in all children with JIA.
Bortezomib Dendrimer Prodrug‐Based Nanoparticle System
Authors: Hu Xuefeng , Chai Zhilan , Lu Linwei , Ruan Huitong , Wang Ruifeng , Zhan Changyou , Xie Cao , Pan Jun , Liu Min , Wang Hao , Lu Weiyue 
Published: February 2019

AbstractBortezomib (BTZ) is mainly used to treat hematologic tumors, such as multiple myeloma and small cell lymphoma. However, its usefulness for solid tumor therapy is limited owing to its poor stability and toxicity in vivo. In the present study, an amphiphilic PEGylated dendrimer with dopamine molecule is synthesized from azide group–functionalized polyethylene glycol and alkyne group–functionalized dendrimer, which is produced from 1,1‐dimethylolpropionic acid and dopamine. The amphiphilic PEGylated dendrimer with dopamine molecule reacts with BTZ to construct a BTZ prodrug‐based nanoparticle through a ultrasonic emulsification method. The BTZ prodrug‐based nanoparticles have greater serum stability than BTZ alone and release the prototype drug in acidic environments. The BTZ prodrug‐based nanoparticle is more effective against subcutaneous tumors than BTZ itself. Furthermore, c(RGDyK) modification significantly improves the antitumor efficacy of the BTZ prodrug‐based nanoparticle with regard to subcutaneous and intracranial tumors. Moreover, the BTZ prodrug‐based nanoparticle significantly reduces the toxicity of BTZ in vivo. Therefore, the PEGylated BTZ dendrimer prodrug‐based nanoparticles have great potential for the treatment of solid tumors in vivo.
Soft Matter Technology at KIT: Chemical Perspective from Nanoarchitectures to Microstructures
Authors: Grosjean Sylvain , Wawryszyn Mirella , Mutlu Hatice , Bräse Stefan , Lahann Joerg , Theato Patrick 
Published: February 2019

AbstractBioinspiration has emerged as an important design principle in the rapidly growing field of materials science and especially its subarea, soft matter science. For example, biological cells form hierarchically organized tissues that not only are optimized and designed for durability, but also have to adapt to their external environment, undergo self‐repair, and perform many highly complex functions. Being able to create artificial soft materials that mimic those highly complex functions will enable future materials applications. Herein, soft matter technologies that are used to realize bioinspired material structures are described, and potential pathways to integrate these into a comprehensive soft matter research environment are addressed. Solutions become available because soft matter technologies are benefitting from the synergies between organic synthesis, polymer chemistry, and materials science.