bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INFLUENCE OF ATORVASTATIN AND ROSUVASTATIN IN ATHEROSCLEROSIS ON THE PARAMETERS OF CELLULAR IMMUNITY AND IN VITRO LEUCOCYTE ACTIVATION
Authors: Filatova A. Yu. , Potekhina A. V. , Ruleva N. Yu. , Radyukhina N. V. , Arefieva T. I. 
Published: September 2018

Aim. To compare the influence of “lipophilic” atorvastatin and “hydrophilic” rosuvastatin on the parameters of cellular immunity in atherosclerosis patients.Material and methods. Totally, 35 participants included, mean age 62 [57;68] y.o., 18 males and 17 females, directed for follow-up to Myasnikov Cardiovascular Center with preliminary diagnosis coronary heart disease, atherosclerosis of coronary and carotid arteries, and with indications for intensified statin therapy. In 17 patients the dosage of atorvastatin was increased from 20 to 80 mg, in 18 — dosage of rosuvastatin from 10 to 40 mg. All patients at baseline and in 1 month, by the methods of direct immune fluorescence and cytofluometry underwent the measurement of content of monocytes and lymphocyte populations in peripheral blood, incl. regulatory and effectory subpopulations of the latter. Under the circumstances of cellular culture the influence studied, of atorvastatin and rosuvastatin on CD4+ T-lymphocytes populations, as the lipopolysaccharideinduced synthesis of cytokines by monocytes of donors blood.Results. At the background of atorvastatin, there was marked increase of relative content of circulating regulatory T-lymphocytes (Treg), increase of the relation of Treg/Thelper 17 (Th17) and changes of cellular immunity parameters. Statins did not influence subpopulations of blood monocytes. There was dose-dependent inhibition by statins of CD4+ T-lymphocytes proliferation: atorvastatin action was noted in 10 nM/L, rosuvastatin — in 10 times higher concentration. Introduction ofstatins, 10-100 nM/L, to the culture of monocytes did not influence neither spontaneous, nor endotoxin induced secretion of cytokines.Conclusion. In therapeutic dosages atorvastatin shows immune modulating activity presenting with an increase of relative content of regulatory T-lymphocytes subpopulations that might be determined by suppression of effectory cells proliferation.
Assessment of Perfusion and Oxygenation of the Human Renal Cortex and Medulla by Quantitative MRI during Handgrip Exercise
Authors: Haddock Bryan Thomas , Francis Susan T. , Larsson Henrik B.W. , Andersen Ulrik B. 
Published: September 2018

Background
Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity.

Methods
To monitor medullary and cortical oxygenation under handgrip exercise–reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise. We used phase-contrast MRI to measure RAF, arterial spin labeling to measure perfusion, and both changes in transverse relaxation time (T2*) and dynamic blood oxygenation level–dependent imaging to measure blood oxygenation.

Results
Handgrip exercise induced a significant decrease in RAF. In the renal medulla, this was accompanied by an increase of oxygenation (reflected by an increase in T2*) despite a significant drop in medullary perfusion; the renal cortex showed a significant decrease in both perfusion and oxygenation. We also found a significant correlation (R
2=0.8) between resting systolic BP and the decrease in RAF during handgrip exercise.

Conclusions
Renal MRI measurements in response to handgrip exercise were consistent with a sympathetically mediated decrease in RAF. In the renal medulla, oxygenation increased despite a reduction in perfusion, which we interpreted as the result of decreased GFR and a subsequently reduced reabsorptive workload. Our results further indicate that the renal flow response’s sensitivity to sympathetic activation is correlated with resting BP, even within a normotensive range.
Serviço Social global em um contexto político: perspectivas radicais
Authors: Uchoa Roberta 
Published: September 2018

Trata-se de resenha do livro Global Social Work in a Political Context: Radical perspectives. Além do suporte da economia política, o livro é marcado pelo internacionalismo. Os autores trazem mais de 20 anos de experiências colaborando com práticas do serviço social crítico em países como Grã-Bretanha, Irlanda, Grécia, Canadá, Estados Unidos (particularmente, Boston), Suécia, Hungria, Hong Kong, Espanha, África do Sul, Nova Zelândia e vários países da América Latina, inclusive o Brasil. Aliás, o Brasil aparece em todos os capítulos que estruturam o livro, com destaque à parte que trata do presente e do passado do serviço social no mundo. As contribuições do serviço social brasileiro, em especial no movimento de reconceituação latino americano nas décadas de 1960 e 1970 e na discussão contemporânea sobre a definição da profissão globalmente, evidenciam que os autores mantêm grande interesse no Brasil e estreita colaboração com profissionais e grupos de pesquisas no campo do serviço social crítico brasileiro desde aquele encontro em Estocolmo.
“Endeavoring to Carry On Their Work”: The National Debate Over Midwives and Its Impact in Rhode Island, 1890–1940
Authors: Caron Simone M. 
Published: September 2018

AbstractThis article analyzes the national discourse over “the problem” of midwifery in medical literature and examines the impact of this dialogue on Rhode Island from 1890 to 1940. Doctors did not speak as a monolithic bloc on this “problem”: some blamed midwives while others impugned poorly trained physicians. This debate led to curricula reform and to state laws to regulate midwifery. The attempt to eliminate midwives in the 1910s failed because of a shortage of trained obstetricians, and because of cultural barriers between immigrant and mainstream communities. A decrease in immigration, an increase in trained obstetricians, the growing notion of midwives as relics of an outdated past, and the emergence of insurance plans to cover “modern” hospital births led to a decline in midwifery.
Educators’ Perceptions of Clinical Judgment Skill Competencies in Rehabilitation Counseling
Authors: Austin Bryan S. 
Published: September 2018

Purpose:To address a significant gap in the clinical judgment competency research by adding new knowledge of important clinical judgment skill competencies in rehabilitation counseling.Method:This Internet-based survey design is a follow-up inquiry to Austin and Leahy’s (2015) instrument validation study; this same sample of rehabilitation counselor educators (n= 126) rated the importance and student preparedness in using clinical judgment skill competencies (i.e., scientific attitude, cultural bias, cognitive complexity, memory bias, confirmatory bias, negative bias, evidence-based practice [EBP]).Results:Clinical judgment skills were perceived to be highly important. Students were rated as least prepared in scientific attitude and evidence-based practice. Ten skills of high importance/limited student preparation across four clinical judgment skill areas were identified.Conclusions:This study’s findings provide initial empirical support of important clinical judgment skill competencies for effective rehabilitation counseling practice. Identified student preparation gaps may be used to help prioritize potential clinical training needs for rehabilitation counseling programs to prepare students in the use of clinical judgment skill competencies that address cultural bias, cognitive complexity, confirmatory bias, and evidence-based practice. Most importantly, data generated from this study can be used when preparing students to effectively address their biases and improve their clinical judgments when applying EBP.
Algunas propiedades homológicas del plano de Jordan
Authors: Suárez Suárez Hector Julio , Gómez Parada Jonatan Andrés 
Published: September 2018

El plano de Jordan puede ser visto como un álgebra cociente, como una extensión de Ore graduada y como unaextensión PBW torcida graduada. Usando estas interpretaciones, se muestra de forma explícita que el plano de Jordan es un álgebra Artin-Schelter regular y Calabi-Yau torcida, además se calcula de forma explícita su automorfismo de Nakayama.
Gelar Adat dalam Upacara Perkawinan Adat Masyarakat Komering di Sukarami Ogan Komering Ilir Sumatera Selatan
Authors: Misyuraidah Misyuraidah 
Published: September 2018

Berbicara tentang Budaya Melayu, Suku Komering adalah rumpun budaya melayu yang memiliki beragam suku, dengan beragamnya suku-suku yang ada di Suku Komering maka dapat di jumpai bermacam-macam adat istiadat, tradisi, dan kesenian yang ada dan sampai pada saat sekarang masih tetap di lestarikan. Hal unik yang akan diteliti di sini adalah gelar adat yang diberikan kepada kedua mempelai dalam upacara perkawinan masyarakat Komering di Sukarami, OKI (Ogan Komering Ilir), Sumatera Selatan. Gelar adat yang dimaksud dalam konteks ini adalah simbol penghormatan terhadap seseorang yang telah menginjak dewasa yang ditandai dengan suatu perkawinan. Ukuran dewasa seorang ditentukan apabila telah berumah tangga. Oleh karena itu, untuk setiap pria pada saat upacara perkawinan ia harus diberi gelar adat, serta mempelai wanitanya juga. Tradisi pemberian gelar adat memiliki implikasi sosial dalam masyarakat berupa pemaknaan gelar adat tersebut di dalam kesehariannya.
Hemicellulose from Plant Biomass in Medical and Pharmaceutical Application: A Critical Review
Authors: Liu Xinxin , Lin Qixuan , Yan Yuhuan , Peng Feng , Sun Runcang , Ren Junli 
Published: September 2018

Background:Due to the non-toxicity, abundance and biodegradability, recently more and more attention has been focused on the exploration of hemicellulose as the potential substrate for the production of liquid fuels and other value-added chemicals and materials in different fields. This review aims to summarize the current knowledge on the promising application of nature hemicellulose and its derivative products including its degradation products, its new derivatives and hemicellulosebased medical biodegradable materials in the medical and pharmaceutical field, especially for inmmune regulation, bacteria inhibition, drug release, anti-caries, scaffold materials and anti-tumor.Methods:We searched the related papers about the medical and pharmaceutical application of hemicellulose and its derivative products, and summarized their preparation methods, properties and use effects.Results:Two hundred and twenty-seven papers were included in this review. Forty-seven papers introduced the extraction and application in immune regulation of nature hemicellulose, such as xylan, mannan, xyloglucan (XG) and β-glucan. Seventy-seven papers mentioned the preparation and application of degradation products of hemicellulose for adjusting intestinal function, maintaining blood glucose levels, enhancing the immunity and alleviating human fatigue fields such as xylooligosaccharides, xylitol, xylose, arabinose, etc. The preparation of hemicellulose derivatives were described in thirty-two papers such as hemicellulose esters, hemicellulose ethers and their effects on anticoagulants, adsorption of creatinine, the addition of immune cells and the inhibition of harmful bacteria. Finally, the preparations of hemicellulose-based materials such as hydrogels and membrane for the field of drug release, cell immobilization, cancer therapy and wound dressings were presented using fifty-five papers.Conclusion:The structure of hemicellulose-based products has the significant impact on properties and the use effect for the immunity, and treating various diseases of human. However, some efforts should be made to explore and improve the properties of hemicellulose-based products and design the new materials to broaden hemicellulose applications.
Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Authors: Kokoska Ladislav , Kloucek Pavel , Leuner Olga , Novy Pavel 
Published: September 2018

:A number of papers reporting antimicrobial properties of extracts, essential oils, resins and various classes of compounds isolated from higher plants have been published in recent years; however, a comprehensive analysis of plant-derived antimicrobial agents currently applied in practice for the improvement of human health is still lacking. This review summarizes data on clinical efficacy, antimicrobial effects and the chemistry of commercially available antibacterial and antifungal agents of plant origin currently used in the prevention and treatment of gastrointestinal, oral, respiratory, skin, and urinary infections. As a result of an analysis of the literature, more than 40 plant-derived over-the-counter pharmaceuticals, dietary supplements, cosmetics, herbal medicines, and functional foods containing complex mixtures (e.g. Glycyrrhiza glabra extract, Melaleuca alternifolia essential oil, and Pistacia lentiscus resin), pure compounds (e.g. benzoic acid, berberine, eucalyptol, salicylic acid and thymol) as well as their derivatives and complexes (e.g. bismuth subsalicylate and zinc pyrithione) have been identified. The effectiveness of many of these products is illustrated by results of clinical trials and supported by data on there in vitro antimicrobial activity. A broad spectrum of various commercial products currently available on the market and their welldocumented clinical efficacy suggests that plants are prospective sources for the identification of new types of antimicrobial agents in future. Innovative approaches and methodologies for effective proof-of-concept research and the development of new types of plant-derived products effective against recently emerging problems related to human microbial diseases (e.g. antimicrobial resistance) are also proposed in this review.
Targeting Long Non-Coding RNAs in Nervous System Cancers: New Insights in Prognosis, Diagnosis and Therapy
Authors: Malissovas Nikos , Ninou Elpinickie , Michail Artemis , Politis Panagiotis K. 
Published: September 2018

:
Long non-coding RNAs (lncRNAs) constitute one of the most broad and diverse
classes of cellular transcripts, playing key roles as regulatory molecules in many biological
processes. Although the biology of lncRNAs is a new and emerging field of research, several
studies have already shown that alterations in the expression of lncRNAs are associated with
the development and progression of cancer in different organs and tissues, including central
and peripheral nervous system. In this review, we summarize the oncogenic and tumor suppressive
roles of lncRNAs in malignant tumors of the nervous system, such as glioma and
neuroblastoma, focusing on their functional interactions with DNA, other RNA and protein
molecules. We further discuss the potential use of lncRNAs as biomarkers for diagnosis,
prognosis and tumor treatment. Gaining insight into the functional association between nervous
system malignancies and lncRNAs could offer new perspectives to the development of
promising therapeutic tools against cancer.
The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases
Authors: Moura Fabiana Andréa , Goulart Marília Oliveira Fonseca , Campos Samara Bonfim Gomes , da Paz Martins Amylly Sanuelly 
Published: September 2018

Background:Inflammatory Bowel Disease (IBD) exhibits no defined aetiology. However, factors such as genetic and nitro-oxidative stress are associated with chronic inflammation and IBD progression to Colorectal Cancer (CRC). The present review discusses the association of nitro-oxidative stress, inflammation and Advanced Glycation End products (AGE) and their corresponding receptor (RAGE) in IBD and examines the connection between these factors and nuclear factors, such as Nuclear Factor Kappa B (NF-κB), factorerythroid 2-related factor-2 (Nrf2), and p53 Mutant (p53M).Methods:We searched the PubMed, ScienceDirect and Web of Science databases using a combination of the following terms: IBD, CRC, oxidative stress, inflammation, NF-κB, Nrf2, p53M, AGE and RAGE.Results:Oxidative stress and inflammation activated two cellular pathways, the nuclear expression of pro-inflammatory, pro-oxidant and pro-oncogenic genes based on NF-κB and p53M, which is associated with NF-κB activation, Deoxyribonucleic acid (DNA) damage and the expression of pro-oncogenic genes. Nrf2 stimulates the nuclear expression of enzymatic and non-enzymatic antioxidant systems and anti-inflammatory genes, and is inhibited by chronic oxidative stress, NF-κB and p53M. AGE/RAGE are involved in inflammation progression because RAGE polymorphisms and increased RAGE levels are found in IBD patients. Alterations of these pathways in combination with oxidative damage are responsible for IBD symptoms and the progression to CRC.Conclusion:IBD is an inflammatory and nitro-oxidative stress-based bowel disease. Achieving a molecular understanding of the biochemical events and their complicated interactions will impact basic and applied research, animal models, and clinical trials.
Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates
Authors: Zhai Rongwei , Rizak Joshua , Zheng Na , He Xiaping , Li Zhenhui , Yin Yong , Su Tao , He Yingge , He Rongqiao , Ma Yuanye , Yang Meifeng , Wang Zhengbo , Hu Xintian 
Published: September 2018

Background:
Formaldehyde (FA) has been implicated in Alzheimer’s disease (AD) pathology
as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) and tau
protein in vitro. Higher levels of FA have also been found in patients with greater cognitive impairment
and in AD patient brains.

Objective:
To directly evaluate the effect of chronically elevated FA levels on the primate brain with
respect to AD pathological markers.

Method:
Young rhesus macaques (5-8 yrs, without AD related mutations) were given chronic intracerebroventricular
(i.c.v.) injections of FA or vehicle over a 12-month period. Monkeys were monitored for
changes in cognitive ability and evaluated post-mortem for common AD pathological markers.

Results:
Monkeys injected with FA were found to have significant spatial working memory impairments.
Histopathological analysis revealed the presence of amyloid-β+ neuritic-like plaques, neurofibrillary
tangle-like formations, increased tau protein phosphorylation, neuronal loss and reactive gliosis in
three memory (and AD) related brain areas (the hippocampus, entorhinal cortex and prefrontal cortex
(PFC)) of monkeys receiving i.c.v. injections of FA. ELISA assays revealed that the amounts of pT181
and Aβ42 were markedly higher in the PFC and hippocampus of FA treated monkeys.

Conclusion:
FA was found to induce major AD-like pathological markers and cognitive impairments in
young rhesus monkeys independent of genetic predispositions. This suggests FA may play a significant
role in the initiation and progression of the disease.
c-Myc Inhibitor 10074-G5 Induces Murine and Human Hematopoietic Stem and Progenitor Cell Expansion and HDR Modulator Rad51 Expression
Authors: Aksoz Merve , Albayrak Esra , Aslan Galip Servet , Turan Raife Dilek , Alyazici Lamia Yazgi , Siyah Pınar , Tuysuz Emre Can , Canikyan Serli , Yucel Dogacan , Meric Neslihan , Gulbas Zafer , Sahin Fikrettin , Kocabas Fatih 
Published: September 2018

Background:c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence.Objective:Targeting modulators of HSC quiescence and metabolism could lead to HSC cell cycle entry with concomitant expansion.Methods and Results:Here we show that c-Myc inhibitor 10074-G5 treatment leads to 2-fold increase in murine LSKCD34low HSC compartment post 7 days. In addition, c-Myc inhibition increases CD34+ and CD133+ human HSC number. c-Myc inhibition leads to downregulation of glycolytic and cyclindependent kinase inhibitor (CDKI) gene expression ex vivo and in vivo. In addition, c-Myc inhibition upregulates major HDR modulator Rad51 expression in hematopoietic cells. Besides, c-Myc inhibition does not alter proliferation kinetics of endothelial cells, fibroblasts or adipose-derived mesenchymal stem cells, however, it limits bone marrow derived mesenchymal stem cell proliferation. We further demonstrate that a cocktail of c-Myc inhibitor 10074-G5 along with tauroursodeoxycholic acid (TUDCA) and i-NOS inhibitor L-NIL provides a robust HSC maintenance and expansion ex vivo as evident by induction of all stem cell antigens analyzed. Intriguingly, the cocktail of c-Myc inhibitor 10074-G5, TUDCA and L-NIL improves HDR related gene expression.Conclusion:These findings provide tools to improve ex vivo HSC maintenance and expansion, autologous HSC transplantation and gene editing through modulation of HSC glycolytic and HDR pathways.
Studying the Gut Microbiome of Latin America and Hispanic/Latino Populations. Insight into Obesity and Diabetes: Systematic Review
Authors: Elena Romero-Ibarguengoitia Maria , Gabriela Garcia-Dolagaray , Arnulfo Gonzalez-Cantu , Enrique Caballero Augusto 
Published: September 2018

Background:
People from Latin America (LA) and the Hispanic/Latino community living in
the United States (LUS) exhibit a high prevalence of diabetes (DM) and obesity (OB). The Gut Microbiome
(GM) is capable of altering energy regulation and glucose metabolism, but for the expression of
these diseases a combination of multiple factors such as ethnicity, genetic and nutritional factors are required.
A systematic research was conducted to understand if the prevalence of OB and/or DM has an
interaction with the GM in LA and LUS.

Methods:
Research was conducted in PubMed, Web of Science, Scielo, Embase and Google Scholar
for articles between 1990 and 2017. It was restricted to human studies published in English, Spanish, or
Portuguese that applied genetic techniques to study the GM in LA or LUS and discussed the association
with OB and/or DM.

Results:
Different gut Firmicutes/Bacteroidetes relationships in several populations from LA influenced
by geography, diet and lifestyles interacted with OB. Healthy people from the Mexico and US
border had the same imbalance between Firmicutes and Bacteroidetes found in OB or Type 2 DM.
High levels of Bacteroides and a reduced proportion of Prevotella, Megamonas, and Acidaminococcus
were found in newly diagnosed type 1 DM. Once the patient was treated with insulin, an increase of
Prevotella levels was seen. Inverse Firmicutes/Bacteroidetes relationship was reported before the development
of Type 1 DM.

Conclusion:
An important relation between GM and OB and/or DM exists in LA and LUS. Further
elucidation of pathophysiologic mechanisms is required.