bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming error fossilization in academic writing: strategies for Saudi EFL learners to move beyond the plateau
Authors: Albelihi Hani Hamad M. , Al-Ahdal Arif 
Published: November 2024

AbstractThe current study explores error fossilization in the academic writing of Saudi English as a Foreign Language (EFL) undergraduate learners. A manual textual analysis approach, employing corpus content analysis on writing across diverse genres including argumentative, expository, narrative, and descriptive essays was conducted to discover the fossilized errors. The results showed that certain errors, such as idiomatic language usage and subject-verb agreement, appear to be fossilized, while others diminish over time. The study highlights specific instances of error fossilization, including challenges related to articles, idiomatic language, plural markers, negative markers, and prepositions. These errors are attributed to factors such as linguistic differences between Arabic and English, limited exposure to authentic language materials, and cultural influences. This study provides valuable insights into the complexities of error fossilization among Saudi EFL undergraduates. By understanding the factors contributed to these errors and their underlying causes, educators can develop tailored approaches to language instruction, ultimately enhancing English proficiency in similar contexts.
Erector spinae plane block for cancer pain relief: a systematic review
Authors: Capuano Paolo , Alongi Antonietta , Burgio Gaetano , Martucci Gennaro , Arcadipane Antonio , Cortegiani Andrea 
Published: November 2024

Abstract
Background
Despite advances in pain management, cancer-related pain remains a critical issue for many patients. In recent years, there has been a growing interest in the use of fascial plane blocks, such as the Erector Spinae Plane Block (ESPB), for managing chronic pain, including in the oncology field. We conducted a systematic review to synthetize existing evidence on the use of ESPB for cancer pain management.

Methods
We selected studies published between January 2016 to April 2024. A systematic search in Pubmed and Embase databases was performed. The search strategy included the following keywords and/or MeSH terms according to the controlled vocabulary of the databases sought: ((erector spinae plane block) OR (ESP block) OR (ESPB) AND ((cancer pain). We considered eligible Randomized, nonrandomized studies, case series and case reports reporting data on the use of ESPB in patients with cancer pain.

Results
The search revealed 34 studies. Among these, we found one RCT, three retrospective studies, two case series, and 28 case reports for a total of 135 patients. Studies included described the use of ESPB for the management of various types of cancer pain across different conditions, including chronic thoracic cancer-related pain, abdominal visceral pain and pain related to bone metastases. Single-shot ESPB was performed in 26 studies while continuous ESPB and the use of a peripheral nerve catheter for continuous analgesia were described in 8 studies. Neurolytic ESPB was performed in 6 studies for a total of 10 patients There was a high clinical heterogeneity in terms of technique, drugs, and use of adjuvants. The lack of comparators was a major flaw, together with the low level of evidence in the majority of the included studies.

Conclusions
The evidence supporting the use of ESPB for cancer pain management is currently scarce, heterogeneous, and of low quality. To better understand its potential and provide robust clinical guidance, future research needs to focus on rigorous comparative studies, standardization of techniques and larger sample sizes.
Submucosal hemorrhage of the esophagus: a case report
Authors: Kojima Risako , Takeno Shinsuke , Ikenoue Makoto , Chiyotanda Teru , Araki Yusuke , Tashiro Kousei , Kawano Fumiaki , Nanashima Atsushi , Furukawa Kouji 
Published: November 2024

Abstract
Background
Submucosal hemorrhage of the esophagus is relatively rare and the course of this disease remains unclear. We report a case of this disease.

Case presentation
The patient was a 68-year-old man who visited a clinic complaining of sudden-onset epigastric and back pain. He had been taking warfarin and a statin due to non-obstructive hypertrophic cardiomyopathy, right subclavian artery stenosis, and chronic atrial fibrillation. Contrast-enhanced computed tomography showed esophageal submucosal hemorrhage. Detailed endoscopic examination was difficult because of the massive hemorrhage and progressive esophageal mucosal edema. He was transferred to our hospital due to progression of anemia. Fortunately, hemorrhagic anemia showed no progression with conservative fasting therapy after admission to our hospital. Esophageal mucosa over the submucosal hemorrhage detached and regenerative tissue was observed on endoscopic examination 1 week later.

Conclusions
Esophageal submucosal hemorrhage should be included among the differential diagnoses for patients presenting with chest and back pain.
A never-ending story: The COVID-19 pandemic and the increase of hospital admissions for typical and atypical anorexia nervosa in children, adolescents and young adults in the post-pandemic era in Germany
Authors: Herpertz-Dahlmann Beate , Eckardt Stefan , Dempfle Astrid 
Published: November 2024

Abstract

Background
A large increase in the rate of hospitalizations for adolescents and children with anorexia nervosa (AN) was observed during the coronavirus disease (COVID-19) pandemic. It is still not clear whether this was a temporary effect or whether the increased admission rates persist.

Methods
Data were retrieved from the largest health insurance in Germany comprising 2.5 million children between 9 and 19 y. All patients of this age group with a discharge diagnosis of typical (AN) and atypical AN (AAN) according to the International Classification of Diseases, Tenth Revision (ICD-10), were included. Admission rates per 10,000 person-years were computed separately by sex, age and type of AN for entire years from 2019 to 2022 and the first half of 2023 in relation to the entire number of insured persons of the same sex and age per year.

Results
Two years after the final lockdown admission rates were still significantly higher in adolescent and childhood AN than in the pre-COVID-19 time. While admission rates declined for adolescents in 2023, those for children remained high, with an increase for girls of more than 40% compared with the rate before the pandemic (1.42 (CI 1.26, 1.60); p < 0.0001). The highest admission risk for AAN relative to the pre-COVID-19 period was observed in adolescents in the first half of 2023 (1.6; CI 1.34; 1.90; p < 0.0001).

Conclusions
Children appear to be especially vulnerable to the pandemic-associated disruptions. Clinicians should try to determine the ongoing effects of the pandemic and support early detection and treatment of AN to prevent its often lifelong consequences.
Serious Games for Serious Pain: Development and Initial Testing of a Cognitive Behavioral Therapy Game for Patients With Advanced Cancer Pain
Authors: Azizoddin Desiree R. , DeForge Sara M. , Edwards Robert R. , Baltazar Ashton R. , Schreiber Kristin L. , Allsop Matthew , Banson Justice , Oseuguera Gabe , Businelle Michael , Tulsky James A. , Enzinger Andrea C. 
Published: November 2024

PURPOSE
Cancer-related pain is prevalent among people with advanced cancer. To improve accessibility and engagement with pain-cognitive behavioral therapy (pain-CBT), we developed and tested a serious game hosted within a mobile health intervention that delivers pain-CBT and pharmacologic support. The game focuses on teaching and practicing cognitive restructuring (CR), a central pain-CBT intervention component.

METHODS
The pain-CBT game was developed through partnerships with commercial and academic game developers, graphic designers, clinical experts, and patients. Patients with metastatic cancer and pain participated in iterative, semistructured interviews. They described their experience playing each level and reflected on relevance, clarity, usability, and potential changes. Content codes captured patients' suggestions and informed game refinements.

RESULTS
The final game includes five levels that prompt players to distinguish between adaptive and maladaptive thoughts that are pain- and cancer-specific. The levels vary in objective (eg, hiking and sledding), interaction type (eg, dragging and tapping), and mode of feedback (eg, audio and animation). Fourteen participants reviewed the game. Patients appreciated the pain- and cancer-specific thought examples, with a few noting that the thoughts made them feel less alone. Many stated that the game was fun, relatable, and an engaging distraction. Others noted that the game provided helpful CR practice and prompted reflection. For example, one 40-year-old woman said the game “brings [a thought] to the forefront so you can acknowledge it, and then maybe you could let it go or… do something about it.”

CONCLUSION
Patients coping with cancer pain found the CR game helpful, enjoyable, and satisfactory. Serious games have the potential to increase engagement while facilitating learning and rehearsal of psychological skills for pain. Future testing will evaluate the efficacy of this serious game.
NEURAL NETWORK MACHINE TRANSLATION IN FOREIGN LANGUAGE TEACHING IN TECHNICAL UNIVERSITY
Authors: Volegzhanina Irina S. , Chusovlyanova Svetlana V. 
Published: November 2024

Background. Mass usage of neural-network machine translation services by students of technical universities when studying foreign languages leads to the necessary changes in the working programme content and teaching instruments. Such a perspective causes ambiguous response among educators, which makes this problem relevant under the conditions of digital transformation of higher education.
Purpose. The authors aim to provide the results of a theoretical and empirical study of how the participants of the foreign language teaching and learning process respond to the mass implementation of neural network machine translators.
Materials and methods. Materials for this article are obtained by the method of questionnaire survey, which is conducted among instructors and students of Novosibirsk technical universities in 2024. For a deeper understanding concerning the attitude of respondents to the implementation of neural network machine translation apps in the teaching and learning process, retrospective conversations with students and semi-formalised interviews with instructors of Foreign Language Departments are conducted.
Results. The findings suggest a predominantly positive attitude of the instructors and students of Novosibirsk technical universities to the implementation of neural network machine translation services in teaching and learning foreign languages. Although there is a tendency to use such services to translate large pieces of their own texts, many students are focused on analysing the quality and editing their translates. The instructors, in their turn, note that neural network machine translators do not solve the problem of linguistic difficulties, especially when translating industry-specific texts. However, they find no reason to ban their students from using neural network machine translation services in classroom and extracurricular activities. Moreover, the instructors emphasise that the use of these instruments should be taught on purpose. Taking into account the respondents’ opinions, the authors offer to add a separate module devoted to the proper use of neural network machine translation services to the working programmes, which will contribute to the development of students’ critical thinking when solving academic, professional and research tasks.
Person-centered and youth-oriented interventions to improve TB Care for adolescents and young adults
Authors: Waterous Patricia , Chingono Rudo , Mackworth-Young Constance , Nyamayaro Chipo , Kandiye Faith Rutendo , Marambire Edson , Schellenberg Joanna , Mutsvangwa Junior , Chonzi Prosper , Kavenga Fungai , Ferrand Rashida , Kranzer Katharina , Bernays Sarah 
Published: November 2024

Introduction
Globally adolescents and young adults (AYA) with tuberculosis (TB) face unique challenges. Until recently they have received little attention and few tailored interventions exist. To improve TB outcomes in this population, there is a need to implement tailored interventions. However, limited research has been conducted about how to meet the needs of AYA with tuberculosis. In this paper we present the findings of a qualitative study to explore the needs of AYA with TB in Zimbabwe and to identify interventions to optimize their engagement in TB care.

Methods
We conducted two participatory workshops with 16 AYA, aged 10–24 years diagnosed with TB to explore their experiences of TB disease and treatment. Through subsequent interviews with 15 of the same AYA and with two other key stakeholder groups (health care providers n = 11 and policy makers n = 9), we sought to identify areas of convergence and divergence about what youth-orientated services and policies would be effective in Zimbabwe. Qualitative data were analyzed iteratively and thematically.

Results
The findings are presented to align with four levels of a socio-ecological framework: individual, community, health system and policy. All three stakeholder groups highlighted the unmet mental health and TB literacy needs of AYA, which are particularly acute early in their TB care journey, as well as the imperative of engendering family support and securing the continuity of educational or employment opportunities during and after receiving TB care. There was a consensus that clinical services needed to become more youth-centered by extending training for health care providers and investing in peer-delivered psychosocial support. More broadly, there was also a strong consensus that adolescent-specific TB policies require further development and implementation, accompanied by community-based TB education and awareness campaigns to emphasize the curability of TB and to reduce TB related stigma.

Conclusions
There is much to be done to improve TB care for AYA. We found that there is need for alignment on where investment is needed to support the development of context-appropriate and effective interventions. There is an opportunity to benefit from translational learning from other successful approaches, such as HIV, within the region. Implementation of evidence-based interventions and youth-friendly policies and programs are much needed to improve outcomes for AYA with TB.
Rationale and study protocol of a regional health panel in Saxony, Germany (GEPASA)
Authors: Harst Lorenz , Haase Tina , Tesch Falko , Rüthrich Lilly , Kösters Markus , Schmitt Jochen 
Published: November 2024

Background
The citizens’ perspectives on health care are central to the assessment of the health care situation and to regional development. In Germany, however, strategic goals for health care delivery are planned based on population statistics and partly on regional morbidity. Saxony is a German federal state with high average age and low density of physicians which makes the population perspective on quality of health care especially intersting. No existing panel surveys cover issues related to the perceived quality of health care delivery on a regional level in Germany.

Aim
We aim to conduct a longitudinal panel study of the perceived health status and perceived quality of health care of the Saxon citizens as a basis for the systematic derivation of health care goals/measures and target group-specific, regionally suitable prevention measures.

Methods
With an anticipated 15% response rate, 15,000 potential participants have to be contacted to achieve a calculated sample size of about 2,250 participants. The questionnaire will be circulated every other year with the option for adaptations depending on insights of each panel wave. The study protocol was approved by the local ethics committee of the Technische Universität Dresden, Germany (ethical approval code BO-EK-320072022) and has been registered at the German Clinical Trials Register as the German WHO primary registry (study registration number DRKS00031229).

Discussion and outlook
The results are intended to identify gaps in health care and to develop patient-centered health care goals for the region together with stakeholders in Saxon health care planning. At the same time, longitudinal data allow mapping of perceived health status and perceived health care trends.
Patient use of pulse oximetry to support management of COVID-19 in Greater Manchester: A non-randomised evaluation using a target trial approach
Authors: Rubinstein Fernando , Williams Richard , Dumville Jo , Kane Binita , Whittaker William , Bower Peter , Kontopantelis Evangelos 
Published: November 2024

Introduction
The pandemic saw widespread use of home pulse oximeters to patients diagnosed with COVID-19 to support early detection of low oxygen saturation levels and appropriate care. Rapid implementation made conventional evaluation challenging, highlighting the need for rigorous non-randomised methods to support decision-making about future use of these technologies. We used routine data to explore the benefits of pulse oximetry in Greater Manchester, under the ‘COVID-19 oximetry at home’ (CO@h) programme.

Methods
We used data from the Greater Manchester Secure Data Environment and defined study parameters using a ‘target trial’ model to compare patients receiving pulse oximetry under the CO@h programme, with matched controls using various comparator groups. Primary outcomes were unplanned hospitalisation and all-cause mortality. This study is based on data from the Greater Manchester Care Record (GMCR), using anonymised, routinely collected data provided in a de-identified format for research. Informed written consent is needed for primary care patient data to be collected for service improvement and research, before data extraction to the GMCR. The study was approved under protocol GMCR RQ-048, on 12/05/2022. As indicated by the University of Manchester ethics decision tool, formal ethical approval was not required for this study.

Results
The adjusted odds ratios for an unplanned hospitalisation were higher among patients receiving pulse oximetry: OR 1.86 (95% CI 1.54–2.25) at 28 days, 1.5 (95% CI 1.3–1.74) at 90 days and 1.63 (95% CI 1.44–1.83) at 1 year. Overall odds of mortality were lower among patients receiving pulse oximetry: adjusted ORs of 0.5 (95% CI 0.25–0.98) at 28 days, 0.5 (95% CI 0.32–0.78) at 90 days and 0.58 (95% CI 0.44–0.76) at 1 year. The results were robust to different comparison groups.

Conclusion
Use of pulse oximetry at home under the CO@h programme, through the resulting prioritisation for appropriate care, was associated with a higher frequency of unplanned admissions and a reduction in the risk of mortality up to 1 year later. Therefore, it is likely effective for early detection of clinical deterioration and timely intervention among patients with COVID-19. Further research is needed to understand whether this is a cost-effective use of healthcare resources.
Stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-Kit receptor activation of JAK2/STAT3 axis in hippocampal neuronal cells
Authors: Shen Haiying , Nie Junjie , Li Guangqing , Tian Hongyan , Zhang Jun , Luo Xiaofeng , Xu Da , Sun Jie , Zhang Dongfang , Zhang Hong , Zhao Guifang , Wang Weiyao , Zheng Zhonghua , Yang Shuyan , Jin Yuji 
Published: November 2024

Background
Alzheimer’s disease (AD) is a common elderly disorder characterized by cognitive decline. Endoplasmic reticulum (ER) stress has been implicated in various neurodegenerative diseases, including AD. Stem cell factor (SCF) performs its biological functions by binding to and activating receptor tyrosine kinase c-Kit. We aimed to investigate the effects of SCF/c-Kit and JAK2/STAT3 on ER stress and apoptosis in AD.

Methods
The study employed L-glutamic acid (L-Glu)-treated HT22 cells as sporadic AD cell model and APP/PS1 mice as an animal model of familiar AD. SCF, c-Kit inhibitor ISCK03 or JAK2/STAT3 inhibitor WP1066 was treated to verify the effects of SCF/c-Kit and JAK2/STAT3 on ER stress and apoptosis of L-Glu-exposed HT22 cells. Cell viability was assessed by MTT. BrdU detected cell proliferation. Flow cytometry measured cell apoptosis. The expression levels of ER stress markers GRP78, PERK, CHOP, and apoptosis protein caspase3 were determined by western blot. The effect on the mRNA of ER stress markers GRP78, PERK, CHOP and apoptotic caspase3 were quantified by RT-qPCR in primary cultured hippocampal neurons from APP/PS1 transgenic mice.

Results
Administration of SCF significantly augmented the activity and proliferation of hippocampal neuronal cells, protecting cells against L-Glu induced ER stress-associated apoptosis. Moreover, the addition of ISCK03 (c-Kit inhibitor) or WP1066 (JAK2/STAT3 inhibitor) reversed SCF effects on ER stress and apoptosis in vitro.

Conclusion
We found that SCF inhibits L-Glu-induced ER stress-associated apoptosis via JAK2/STAT3 axis in HT22 hippocampal neuronal cells, as well as in primary hippocampal neurons from APP/PS1 mice, which provides valuable insights into the molecular mechanisms underlying the pathogenesis of AD and explores novel therapeutic targets for both sporadic and familial AD.
Comparison of outcomes between video laryngoscopy and flexible fiberoptic bronchoscopy for endotracheal intubation in adults with cervical neck immobilization: A systematic review and meta-analysis of randomized controlled trials
Authors: Guo Nana , Wen Xuxin , Wang Xiao , Yang Junling , Zhou Haidong , Guo Jianli , Su Yun , Zhang Tingxin 
Published: November 2024

Purpose
Comparing the outcomes of video-laryngoscopy and flexible fiberoptic bronchoscopy for endotracheal intubation in patients with cervical spine immobilization

Methods
All of the comparative studies published in the PubMed, Cochrane Library, Medline, Web of Science, and EMBASE databases as of 8 Jan 2024 were included. All outcomes were analyzed using Review Manager 5.4. The primary outcomes were the successful first-attempt intubation rate, intubation time, heart rate after intubation, mean arterial pressure after intubation, overall intubation success rate, risk of tissue damage and sore throat.

Results
The meta-analysis included six randomized controlled studies with a total of 694 patients. The outcomes of the meta-analysis revealed that the use of video laryngoscopy was better than flexible fiberoptic bronchoscopy in terms of the successful first-attempt intubation rate (P<0.05) and intubation time (P<0.05) in patients with cervical spine immobilization. However, there were no statistically significant differences in heart rate after intubation, mean arterial pressure after intubation, overall intubation success rate, risk of tissue damage, or sore throat (all P>0.05) between the video laryngoscopy and flexible fiberoptic bronchoscopy groups.

Conclusions
Compared with flexible fiberoptic bronchoscopy, video laryngoscopy has superior tracheal intubation performance in terms of the first-attempt success rate and intubation speed. This finding was observed in patients with cervical spine immobilization who utilized a cervical collar to simulate a difficult airway. Additionally, both types of scopes demonstrated similar complication rates. Current evidence suggests that video laryngoscopy is better suited than flexible fiberoptic bronchoscopy for endotracheal intubation in patients immobilized with a cervical collar.

Trial registration
Systematic review protocol: CRD42024499868.