bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal of control laws for turbulent skin friction reduction based on resolvent analysis
Authors: Kawagoe Aika , Nakashima Satoshi , Luhar Mitul , Fukagata Koji 
Published: March 2019

This paper evaluates and modifies the so-called suboptimal control technique for turbulent skin friction reduction through a combination of low-order modelling and direct numerical simulation (DNS). In a previous study, Nakashima et al. (J. Fluid Mech., vol. 828, 2017, pp. 496–526) employed resolvent analysis to show that the efficacy of suboptimal control was mixed across spectral space when the streamwise wall shear stress (case ST) was used as a sensor signal, i.e. specific regions of spectral space showed drag increment. This observation suggests that drag reduction may be attained if control is applied selectively in spectral space. DNS results presented in the present study, however, do not show a significant effect on the flow with selective control. A posteriori analyses attribute this lack of efficacy to a much lower actuation amplitude in the simulations compared to model assumptions. Building on these observations, resolvent analysis is used to design and provide a preliminary assessment of modified control laws that also rely on sensing the streamwise wall shear stress. Control performance is then assessed by means of DNS. The proposed control laws generate as much as $10\,\%$ drag reduction, and these results are broadly consistent with resolvent-based predictions. The physical mechanisms leading to drag reduction are assessed via conditional sampling. It is shown that the new control laws effectively suppress the near-wall quasi-streamwise vortices. A physically intuitive explanation is proposed based on a separate evaluation of clockwise and anticlockwise vortices.
Organizational innovation culture and firms’ new product performance in two emerging markets: The moderating effects of institutional environments and organizational cohesion
Authors: Xie Xuemei , Wu Yonghui , Xie Peihong , Yu Xiaoyu , Wang Hongwei 
Published: March 2019

AbstractAs a source of competitive advantages for firms, innovation has boosted scholars’ interest in the identification of its main determinants from the perspective of organizational culture. However, there is a lack of research on innovation cultures in the context of emerging markets. Based on survey data from 433 manufacturing firms (331 Chinese firms and 102 Vietnamese firms), this study addresses this research gap using a hierarchical regression analysis to explore the impact of organizational innovation culture on firms’ new product performance and to examine the moderating effects of institutional environments and organizational cohesion on this relationship. We find that there are positive relationships between organizational innovation culture and firms’ new product performance. In contrast to recent research on organizational cohesion, we report that organizational cohesion has both a direct, positive effect on new product performance and a positive moderating role in organizational innovation culture and firms’ new product performance. Furthermore, regarding the institutional environment in the context of emerging markets, we find that the effects of organizational innovation culture on firms’ new product performance are stronger in China than in Vietnam. Therefore, this paper enriches organizational culture research by providing a multidimensional theoretical framework and extends institutional theory in the context of emerging markets by examining the moderating effect of institutional environments on the relationship between organizational innovation culture and firms’ new product performance in both China and Vietnam.
Fault rocks within the blueschist metabasalts of the Diamante–Terranova unit (southern Italy): potential fossil record of intermediate-depth subduction earthquakes
Authors: Vitale Stefano , Fedele Lorenzo , Tramparulo Francesco D’Assisi , Prinzi Ernesto Paolo 
Published: March 2019

AbstractWe report the first evidence of fault rocks (FRs) developed during high-pressure/low-temperature (HP/LT) subduction-related metamorphism, within quartz+epidote pods embedded in the glaucophane–lawsonite-bearing ophiolitic metabasalts of the Diamante–Terranova unit (Calabria, Italy). FRs occur as relic injections appearing as thin dark seams, locally showing an internal foliation characterized by tabular, curvilinear and meander-like shapes, and consist of very fine grains of glaucophane and titanite, locally including survivor clasts of epidote and lawsonite. Some boudinaged veins show glaucophane fibres in the boudin necks, marking a clear HP/LT syn-metamorphic origin at c. 30 km depth. The injected FRs can be alternatively interpreted either as pseudotachylytes or as fluidized ultracataclasites. Although subsequent recrystallization largely obliterated primary diagnostic features, the occurrence of (i) different-coloured flow streaks, characterized by alternating layers of glaucophane and titanite, (ii) well-developed flow folds and (iii) corroded epidote survivor crystals could indicate a viscous flow of molten material characterized by a non-uniform chemical composition. With this in mind, we support the hypothesis that these fine-grained veins were originally pseudotachylytes generated by the frictional melting of the glaucophane-rich layers of the Diamante–Terranova metabasalts, likely related to seismic events occurring during the Eocene along thrust faults within the subducting oceanic Ligurian lithosphere. The lack of evidence for pseudotachylyte relics in the metabasalt source rock argues for a selective preservation, largely dependent on the efficient mechanical shielding action of the stiffer quartz+epidote pods.
Costs of coexistence: understanding the drivers of tolerance towards Asian elephants Elephas maximus in rural Bangladesh
Authors: Saif Omar , Kansky Ruth , Palash Anwar , Kidd Martin , Knight Andrew T. 
Published: March 2019

AbstractHabitat degradation and fragmentation have heightened the importance of understanding human tolerance towards wildlife, as the fate of wildlife in multi-use landscapes depends on people's capacity for coexistence. We applied the wildlife tolerance model to examine drivers of tolerance towards Asian elephants Elephas maximus in rural Bangladesh, interviewing local people in 17 villages. We used structural equation modelling to identify causal pathways in which elephant-related exposure, positive and negative interactions, costs and benefits (tangible and intangible) contributed to tolerance. Contrary to expectations, monetary costs were non-significant in shaping tolerance despite major impacts on livelihoods. Instead, intangible costs and intangible benefits were significant factors determining tolerance. Furthermore, reducing people's exposure to elephants would not necessarily affect tolerance, nor would increasing positive interactions. We discuss how the socio-economic and bio-cultural dynamics of local communities can explain these results, and demonstrate how our model can be used to incorporate such complexities into conservation decision-making. For instance, compensation schemes aim to recompense monetary losses and direct damages, to improve tolerance, whereas our results suggest a more effective approach would be to enhance resilience to non-monetary costs and improve perceived benefits. We conclude that future studies should pay increased attention to intangible costs and consider the less direct drivers of tolerance. Through repeated testing of universal models such as that presented here, broad trends may emerge that will facilitate the application of policies across contexts and landscapes.
WHERE IS SALUT?
Authors: Josel Seth F. 
Published: March 2019

AbstractI first performed Salut für Caudwell (1977) at November Music in Den Bosch, two and half years ago. The festival celebrated Lachenmann's eightieth birthday in grand style, and the composer himself attended. During a backstage chat, Lachenmann, whom I've known for around 20 years, casually hinted that there were things ‘missing’ in the print edition of the work, published in 1985: that is, that performative information in the fair copy was not fully reproduced in the print edition. At that moment, my curiosity was piqued intensely, and the seed of a new edition was planted. While I understood the formidable challenges involved in properly preparing the part, rehearsing, and traversing this Everest of the guitar literature, I was not fully prepared for the astonishing array of hazards that awaited me. This article describes the labyrinth of sketches, drafts, and score iterations I encountered in beginning to prepare a new edition of Salut for Lachenmann's publishers, Breitkopf & Härtel.
Food seeking and food sharing under uncertainty
Authors: Aharonov-Majar Efrat , Suleiman Ramzi 
Published: March 2019

AbstractWe propose an elaboration of Anselme and Güntürkün's research that considers individuals’ foraging behavior as part of group efforts to cope with uncertainty. We discuss different possibilities for the interaction between individual and group mechanisms for risk reduction in uncertain environments, and we raise some open questions for future research.
Wideband out-of-phase power dividers with improved isolation performance
Authors: Song Kaijun , Xia Fei , Chen Yuxuan , Zhu Yu , Li Jiawei , Fan Yong 
Published: March 2019

AbstractA compact wideband out-of-phase power divider (PD) with improved isolation performance is proposed. This divider is formed by connecting an additional stub for isolation to output ports of a traditional Marchand balun with a defected ground structure (DGS) been used. To verify the design, a prototype divider is fabricated and tested. The measured results validate the 53.86% band-width centered at 3.43 GHz with more than 15 dB return loss at all ports, more than 17 dB isolation, respectively.
Effect of rate and timing of indaziflam on ‘Sunbelt’ and muscadine grape
Authors: Basinger Nicholas T. , Jennings Katherine M. , Monks David W. , Mitchem Wayne E. 
Published: March 2019

AbstractStudies were conducted at six locations across North Carolina to determine tolerance of ‘Sunbelt’ grape (bunch grape) and muscadine grape (‘Carlos’, ‘Triumph’, ‘Summit’) to indaziflam herbicide. Treatments included indaziflam (0, 50, 73 g ai ha–1) or flumioxazin (213 g ai ha–1) applied alone in April, and sequential applications of indaziflam (36, 50, 73 g ai ha–1) or flumioxazin (213 g ai ha–1) applied in April followed by the same rate applied in June. No crop injury was observed across locations. Muscadine yield was not affected by herbicide treatments. Yield of ‘Sunbelt’ grape increased with sequential applications of indaziflam at 73 g ha–1when compared to a single application of indaziflam at 50 g ha–1or flumioxazin at 213 g ha–1in 2015. Sequential applications of flumioxazin at 213 g ha–1reduced ‘Sunbelt’ yield compared to a single application of indaziflam at 73 g ha–1in 2016. Trunk cross-sectional area was unaffected by herbicide treatments. Fruit quality (soluble solids concentration, titratable acidity, and pH) for muscadine and bunch grape was not affected by herbicide treatments. Indaziflam was safe to use at registered rates and could be integrated into weed management programs for southern US vineyards.
Ocean Acidification Regulates the Activity, Community Structure, and Functional Potential of Heterotrophic Bacterioplankton in an Oligotrophic Gyre
Authors: Xia Xiaomin , Wang Yu , Yang Yunlan , Luo Tingwei , Van Nostrand Joy D. , Zhou Jizhong , Jiao Nianzhi , Zhang Rui 
Published: March 2019

AbstractOcean acidification (OA), a consequence of increased global carbon dioxide (CO2) emissions, is considered a major threat to marine ecosystems. Its effects on bacterioplankton activity, diversity, and community composition have received considerable attention. However, the direct impact of OA on heterotrophic bacterioplankton is often masked by the significant response of phytoplankton due to the close coupling of heterotrophic bacterioplankton and autotrophs. Here we investigated the responses of a heterotrophic bacterioplankton assemblage to high pCO2 (790‐ppm) treatment in warm tropical western Pacific waters by conducting a microcosm experiment in dark for 12 days. Heterotrophic bacterioplankton abundance and production were enhanced by OA over the first 6 days of incubation, while the diversity and species richness were negatively affected. Bacterioplankton community composition in the high pCO2 treatment changed faster than that in the control. The molecular ecological network analysis showed that the elevated CO2 changed the overall connections among the bacterial community and resulted in a simple network under high CO2 condition. Species‐specific responses to OA were observed and could be attributed to the different life strategies and to the ability of a given species to adapt to environmental conditions. In addition, high‐throughput functional gene array analysis revealed that genes related to carbon and nitrogen cycling were positively affected by acidification. Together, our findings suggest that OA has direct effects on heterotrophic bacterioplankton in a low‐latitude warm ocean and may therefore affect global biogeochemical cycles.
Reply to comment by Kong et al. on “Appropriate Boundary Condition for Dupuit‐Boussinesq Theory on the Steady Groundwater Flow in an Unconfined Sloping Aquifer With Uniform Recharge”
Authors: Wu Ying‐Hsin , Sayama Takahiro , Nakakita Eiichi 
Published: March 2019

AbstractThe article aims to respond a comment made on our paper about appropriate boundary condition for the original Dupuit‐Boussinesq theory for two‐dimensional steady groundwater flow in an unconfined sloping aquifer with uniform rainfall recharge. To respond to the comments arguing the existence of lateral groundwater flows and negative groundwater table, clarifications are made for our analysis focusing on two‐dimensional groundwater flow without considering lateral effects by using the original and classical approximate theory.
Modelling microbiome recovery after antibiotics using a stability landscape framework
Authors: Shaw Liam P , Bassam Hassan , Barnes Chris P , Walker A Sarah , Klein Nigel , Balloux Francois 
Published: March 2019

Abstract
Treatment with antibiotics is one of the most extreme perturbations to the human microbiome. Even standard courses of antibiotics dramatically reduce the microbiome’s diversity and can cause transitions to dysbiotic states. Conceptually, this is often described as a ‘stability landscape’: the microbiome sits in a landscape with multiple stable equilibria, and sufficiently strong perturbations can shift the microbiome from its normal equilibrium to another state. However, this picture is only qualitative and has not been incorporated in previous mathematical models of the effects of antibiotics. Here, we outline a simple quantitative model based on the stability landscape concept and demonstrate its success on real data. Our analytical impulse-response model has minimal assumptions with three parameters. We fit this model in a Bayesian framework to data from a previous study of the year-long effects of short courses of four common antibiotics on the gut and oral microbiomes, allowing us to compare parameters between antibiotics and microbiomes, and further validate our model using data from another study looking at the impact of a combination of last-resort antibiotics on the gut microbiome. Using Bayesian model selection we find support for a long-term transition to an alternative microbiome state after courses of certain antibiotics in both the gut and oral microbiomes. Quantitative stability landscape frameworks are an exciting avenue for future microbiome modelling.
Active and diverse viruses persist in the deep sub-seafloor sediments over thousands of years
Authors: Cai Lanlan , Jørgensen Bo B , Suttle Curtis A , He Maoqiu , Cragg Barry A , Jiao Nianzhi , Zhang Rui 
Published: March 2019

Abstract
Viruses are ubiquitous and cause significant mortality in marine bacterial and archaeal communities. Little is known about the role of viruses in the sub-seafloor biosphere, which hosts a large fraction of all microbes on Earth. We quantified and characterized viruses in sediments from the Baltic Sea. The results show that the Baltic Sea sub-seafloor biosphere harbors highly abundant viruses with densities up to 1.8 × 1010 viruses cm−3. High potential viral production down to 37 meters below seafloor in ca. 6000-years-old sediments and infected prokaryotic cells visible by transmission electron microscopy demonstrate active viral infection. Morphological and molecular data indicate that the highly diverse community of viruses includes both allochthonous input from the overlying seawater and autochthonous production. The detection of cyanophage-like sequences showed that viruses of phototrophic hosts may persist in marine sediments for thousands of years. Our results imply that viruses influence sub-seafloor microbial community dynamics and thereby affect biogeochemical processes in the sub-seafloor biosphere.
TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis
Authors: Suzuki Hidefumi , Okamoto-Katsuyama Mayumi , Suwa Tetsufumi , Maeda Ryo , Tamura Taka-aki , Yamaguchi Yuki 
Published: March 2019

AbstractTranscription and DNA damage repair act in a coordinated manner. Recent studies have shown that double-strand DNA breaks (DSBs) are repaired in a transcription-coupled manner. Active transcription results in a faster recruitment of DSB repair factors and expedites DNA repair. On the other hand, transcription is repressed by DNA damage through multiple mechanisms. We previously reported that TLP, a TATA box-binding protein (TBP) family member that functions as a transcriptional regulator, is also involved in DNA damage-induced apoptosis. However, the mechanism by which TLP affects DNA damage response was largely unknown. Here we show that TLP-mediated global transcriptional repression after DSBs is crucial for apoptosis induction by DNA-damaging agents such as etoposide and doxorubicin. Compared to control cells, TLP-knockdown cells were resistant to etoposide-induced apoptosis and exhibited an elevated level of global transcription after etoposide exposure. DSBs were efficiently removed in transcriptionally hyperactive TLP-knockdown cells. However, forced transcriptional shutdown using transcriptional inhibitors α-amanitin and 5,6-dichloro-1-ß-D-ribofuranosylbenzimidazole (DRB) slowed down DSB repair and resensitized TLP-knockdown cells to etoposide. Taken together, these results indicate that TLP is a critical determinant as to how cells respond to DSBs and triggers apoptosis to cells that have sustained DNA damage.
DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation
Authors: Arredouani Abdelilah , Diane Abdoulaye , Khattab Namat , Bensmail Ilham , Aoude Imad , Chikri Mohamed , Mohammad Ramzi , Abou-Samra Abdul Badi , Dehbi Mohammed 
Published: March 2019

AbstractFailure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. We recently showed that DNAJB3 co-chaperone is downregulated in obese and diabetic patients and that physical exercise restores its normal expression with a significant improvement of the clinical outcomes. In 3T3-L1 adipocytes, DNAJB3 has a role in improving the sensitivity to insulin and glucose uptake. In co-immunoprecipitation assays, DNAJB3 interacts with both JNK1 and IKKβ kinases. However, the functional impact of such interaction on their activities has not been investigated. Here, we assessed the effect of DNAJB3 on the respective activity of JNK1 and IKKβ in cell-based assays. Using JNK1- and IKKβ-dependent luciferase reporters, we show a marked decrease in luciferase activity by DNAJB3 in response to PMA and TNF-α that was consistent with a decrease in the translocation of p65/NF-κB to the nucleus in response to LPS. Furthermore, TNF-α-mediated IL-6 promoter activation and endogenous mRNA expression are significantly abrogated by DNAJB3 both in 3T3-L1 and C2C12 cells. The ability of DNAJB3 to mitigate ER stress and oxidative stress was also investigated and our data show a significant improvement of both forms of stress. Finally, we examined the effect of overexpressing and knocking down the expression of DNAJB3 on glucose uptake in C2C12 as well as the molecular determinants. Accordingly, we provide evidence for a role of DNAJB3 in promoting both basal and insulin-stimulated glucose uptake. Our finding reveals also a novel role of DNAJB3 in eliciting Glut4 translocation to the plasma membrane. These results suggest a physiological role of DNAJB3 in mitigating metabolic stress and improving glucose homeostasis and could therefore represent a novel therapeutic target for type 2 diabetes.
NK Cell-Mediated Processing Of Chlamydia psittaci Drives Potent Anti-Bacterial Th1 Immunity
Authors: Radomski Nadine , Franzke Kati , Matthiesen Svea , Karger Axel , Knittler Michael R. 
Published: March 2019

AbstractNatural killer (NK) cells are innate immune cells critically involved in the early immune response against various pathogens including chlamydia. Here, we demonstrate that chlamydia-infected NK cells prevent the intracellular establishment and growth of the bacteria. Upon infection, they display functional maturation characterized by enhanced IFN-γ secretion, CD146 induction, PKCϴ activation, and granule secretion. Eventually, chlamydia are released in a non-infectious, highly immunogenic form driving a potent Th1 immune response. Further, anti-chlamydial antibodies generated during immunization neutralize the infection of epithelial cells. The release of chlamydia from NK cells requires PKCϴ function and active degranulation, while granule-associated granzyme B drives the loss of chlamydial infectivity. Cellular infection and bacterial release can be undergone repeatedly and do not affect NK cell function. Strikingly, NK cells passing through such an infection cycle significantly improve their cytotoxicity. Thus, NK cells not only protect themselves against productive chlamydial infections but also actively trigger potent anti-bacterial responses.
Bacteriophage T4 capsid as a nanocarrier for Peptide-N-Glycosidase F immobilization through self-assembly
Authors: Zhang Liang , Wang Pei , Wang Chang , Wu Yike , Feng Xiaojun , Huang He , Ren Lujing , Liu Bi-Feng , Gao Song , Liu Xin 
Published: March 2019

AbstractEnzyme immobilization is widely applied in biocatalysis to improve stability and facilitate recovery and reuse of enzymes. However, high cost of supporting materials and laborious immobilization procedures has limited its industrial application and commercialization. In this study, we report a novel self-assembly immobilization system using bacteriophage T4 capsid as a nanocarrier. The system utilizes the binding sites of the small outer capsid protein, Soc, on the T4 capsid. Enzymes as Soc fusions constructed with regular molecular cloning technology expressed at the appropriate time during phage assembly and self-assembled onto the capsids. The proof of principle experiment was carried out by immobilizing β-galactosidase, and the system was successfully applied to the immobilization of an important glycomics enzyme, Peptide-N-Glycosidase F. Production of Peptide-N-Glycosidase F and simultaneous immobilization was finished within seven hours. Characterizations of the immobilized Peptide-N-Glycosidase F indicated high retention of activity and well reserved deglycosylation capacity. The immobilized Peptide-N-Glycosidase F was easily recycled by centrifugation and exhibited good stability that sustained five repeated uses. This novel system uses the self-amplified T4 capsid as the nanoparticle-type of supporting material, and operates with a self-assembly procedure, making it a simple and low-cost enzyme immobilization technology with promising application potentials.