bluuebunny/crossref_metadata_2025_split huggingface dataset:
CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity
Authors: Cottrell Graeme S. , Soubrane Camille H. , Hounshell James A. , Lin Hong , Owenson Venetia , Rigby Michael , Cox Peter J. , Barker Bryan S. , Ottolini Matteo , Ince Selvi , Bauer Claudia C. , Perez-Reyes Edward , Patel Manoj K. , Stevens Edward B. , Stephens Gary J. 
Published: September 2018

The putative cache (Ca2+channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ voltage-gated Ca2+channel auxiliary subunit family. CACHD1 mRNA and protein were highly expressed in the male mammalian CNS, in particular in the thalamus, hippocampus, and cerebellum, with a broadly similar tissue distribution to CaV3 subunits, in particular CaV3.1. In expression studies, CACHD1 increased cell-surface localization of CaV3.1, and these proteins were in close proximity at the cell surface, consistent with the formation of CACHD1-CaV3.1 complexes. In functional electrophysiological studies, coexpression of human CACHD1 with CaV3.1, CaV3.2, and CaV3.3 caused a significant increase in peak current density and corresponding increases in maximal conductance. By contrast, α2δ-1 had no effect on peak current density or maximal conductance in CaV3.1, CaV3.2, or CaV3.3. A comparison of CACHD1-mediated increases in CaV3.1 current density and gating currents revealed an increase in channel open probability. In hippocampal neurons from male and female embryonic day 19 rats, CACHD1 overexpression increased CaV3-mediated action potential firing frequency and neuronal excitability. These data suggest that CACHD1 is structurally an α2δ-like protein that functionally modulates CaV3 voltage-gated calcium channel activity.SIGNIFICANCE STATEMENTThis is the first study to characterize the Ca2+channel and chemotaxis receptor domain containing 1 (CACHD1) protein. CACHD1 is widely expressed in the CNS, in particular in the thalamus, hippocampus, and cerebellum. CACHD1 distribution is similar to that of low voltage-activated (CaV3, T-type) calcium channels, in particular to CaV3.1, a protein that regulates neuronal excitability and is a potential therapeutic target in conditions such as epilepsy and pain. CACHD1 is structurally an α2δ-like protein that functionally increases CaV3 calcium current. CACHD1 increases the presence of CaV3.1 at the cell surface, forms complexes with CaV3.1 at the cell surface, and causes an increase in channel open probability. In hippocampal neurons, CACHD1 causes increases in neuronal firing. Thus, CACHD1 represents a novel protein that modulates CaV3 activity.
The determinants of early breast cancer detection via breast self-examination (BSE) in Denpasar, Bali
Authors: Febriyanti Ni Made Ari , Lubis Dinar , Wirawan Dewa Nyoman , Suariyani Ni Luh Putu , Karmaya Mangku 
Published: September 2018

AbstractBackground and purpose: Breast cancer is the leading cause of death in females, followed by colorectal cancer. Early detection of breast cancer can be done through breast self-examination (BSE). BSE behaviour is influenced by an individual’s level of knowledge and perceptions of the procedure. This study examines the determinants of BSE behaviour in married women aged 15-49 in six villages in the working area of Puskesmas (public health centre) II in West Denpasar, Bali, Indonesia.Methods: A cross-sectional survey was employed with 180 respondents selected by multistage random sampling. Data were collected using standardised questionnaire carried out from November-December 2016. Multiple poisson regression was used to identify the determinants of the BSE behaviours.Results: The proportion of respondents who performed BSE in the three months prior to interview is 55.6%, and, of these, 50.0% reported performing BSE regularly. Multivariate analysis shows the significant determinants of BSE are: high-school and above (APR= 2.03; 95%CI:1.41 to 2.92); having a good knowledge of BSE (APR=1.41; 95%CI:1.09 to 1.82); perceived benefits (APR=2, 24; 95%CI:1.53-3.29); perceived low barrier (APR=1.63; 95%CI:1.16-2.29); and high self-efficacy (APR=1.50;95%CI:1.16-1.95).Conclusions: Level of education, good knowledge of BSE, perceived benefits, perceived low barriers, and high level of self-efficacy are the significant determinants of BSE practice. These findings suggest that education on BSE should be enhanced, particularly for women with lower levels of education.
SORPTION OF FLUORIDE IONS BY IRON OXYHYDRATE FIXED ON THE CARRIERS. Part 1. Organic carriers
Authors: Yegorov V. V. , Makovskaya O. Yu. , Mamyachenkov S. V. , Kozlov P. A. 
Published: September 2018

The article considers possibility of using inorganic sorbent – iron oxyhydrate (IOH) – to remove F– ions from process solutions of zinc production. The method of IOH synthesis is chosen. The results of scanning electron microscopy and X-ray phase analysis are presented. The principal possibility of using ion-exchange resins as IOH-modified carriers is considered. The paper studies active substance formation on anion and cation exchange resins. It is shown that the most durable composite sorbents are obtained using strongly acidic cation exchange resins with SO3– groups. A method for introducing IOH into the structure of carrier materials and obtaining composite sorbents is described. The KU-2×8 strongly acidic cation exchanger is recommended as a composite base. Cation exchangers saturated with iron were held in a sodium chloride solution with a concentration of 2,5 g/dm3 for 24 hours at 85 °C to ensure formation of β-modification IOH crystals distributed over the ion exchanger grain volume. Anion exchangers were held in an iron(III) sulfate solution with added sodium chloride for 24 hours at 85 °C. At the same time, iron oxyhydrate films formed on the surface of sorbent grains were observed. Fluorine sorption was carried out in a static mode from a standardized test solution with a concentration of F– = 100 mg/dm3 at 60 °C. Sorption on the AB-17×8 anionite was carried out at 20 °C. Absorbed fluorine was desorbed by the NaOH (0,1 M) solution at 60 °C for 2 hours. The synthesized KU-2×8-IOH composite sorbent has a fluorine capacity of 0,7–1,1 mg/g, and can be regenerated with resulting easily utilizable fluorine-containing eluate.
Pazar Tabanlı Yeteneklerin İşletme Performansı Üzerindeki Etkisi: Türkiye İmalat İşletmelerinde Bir Uygulama
Authors: Hamşıoğlu Ahmet Buğra , Durukan Tülin 
Published: September 2018

Bu
çalışmanın amacı, kaynak tabanlı kuram ekseninde pazar tabanlı yetenekleri
incelemek ve bu bağlamda Türkiye imalat işletmelerinde pazar tabanlı
yeteneklerin işletme performansı üzerindeki etkilerini belirlemektir. Türkiye
imalat işletmeleri listesine bağlı olarak büyük ve orta boy imalat işletmeler
belirlenmiştir. Belirlenen bu işletmelerden, 500 işletme yöneticisine anket
yöntemi uygulanarak araştırma gerçekleştirilmiştir. Elde edilen verilerin
analizinde; SPSS 16.0 paket programından yararlanılarak analiz edilmiştir. Oluşturulan modeli ve hipotezleri test etmek
amacıyla kısmi en küçük kareler yöntemi kullanılmıştır. Araştırmada kullanılan
ölçeklerin geçerlilikleri ve güvenilirleri test edilmiş ve daha sonara hem
ölçüm modeli hem de yapısal model SMART PLS programı yardımı ile analiz
edilmiştir. Bu çalışmanın sonucu olarak, pazar tabanlı yeteneklerin işletme
performansı üzerinde doğrudan ve pozitif etkileri olduğu görülmüştür.
Spectral, Thermal and In Vitro Antibacterial Studies on Cadmium(II)– bis(2,2/-methylidenephenol)diaminoethane
Authors: FELİX Nworie 
Published: September 2018

The objective of this work is to prepare a new synthetic protocol of the cadmium(II) complex of bis(2,2’-methylylidenephenol)diaminoethane (H2BMPDE) and study the antimicrobial bioefficacy. In this work, we report the extractive method for the synthesis of cadmium(II) complex of bis(2,2’-methylidenephenol)diaminoethane from salicylaldehyde, ethylenediamine, hydrochloric acid, and cadmium sulfate in a single, simple step. The ligand and the complex were characterized by FTIR, UV-Vis, 1H and 13C NMR, magnetic moment, GC-MS, thermal and elemental analysis. The chemical data indicated the formation of 1:1 (metal:ligand) mole ratio and distorted tetrahedral geometry was suggested as based on spectral data and magnetic moment. The results of preliminary antibacterial study revealed that Cd(II) H2BMPDE complexes prepared from different acids (HCl, HNO3, H2SO4) were effective against clinically important Gram-negative bacteria (Escherichia coli, pseudomonas, Klebsiella ) and Gram-positive bacterium (Staphylococcus aureus).The result indicated a new synthetic protocol for the synthesis of H2BMPDE complexes. On the application, H2BMPDE and its complexes could be considered as a potential antibacterial agent with further investigative analysis.
Dahiliye Kliniklerinde Çalışan Hemşirelerin Konumlandırma Kullanım Özellikleri
Authors: ÇUVALCİ Burcu , HİNTİSTAN Sevilay 
Published: September 2018

Özet Amaç: Son
yıllarda sağlık hizmetlerinde olan yenilikler, artan rekabet, tüketicilerin
bilinçlenmesi gibi durumlar hizmette bir adım öne geçmeyi, tercih edilen olmayı
zorunlu kılmaktadır. Farklı olmak ve bu olguyu sağlıklı/hasta bireyin zihnine
yerleştirebilmek tercih edilebilir olmayı ve marka olmayı beraberinde
getirmektedir. Bu nedenle hizmet, somut delillerle bireye sunulmalı ve zihninde
bir konum kazanmalıdır. Bu çalışmanın
temel amacı, “profesyonellik” ilkesinde, dahiliye kliniklerinde çalışan hemşirelerin
konumlandırma kullanım özelliklerini değerlendirmektir.Gereç ve Yöntem:
Tanımlayıcı nitelikte olan bu çalışma
Trabzon ilinde bir üniversite hastanesinde, 01-28 Şubat 2015 tarihleri arasında
gerçekleştirildi. Araştırmanın evrenini ve örneklemini dahiliye kliniklerinde
çalışan 186 hemşire oluşturdu ancak çalışma 170 hemşire ile tamamlandı.
Veriler, “Kişisel Bilgi Formu” ve “Konumlandırma Bilgi Formu” kullanılarak toplandı. Araştırma sonucunda elde
edilen veriler sayı, yüzde ve ortalama olarak değerlendirildi.Bulgular: Dahiliye kliniklerinde çalışan hemşirelerin %67.1’i lisans mezunu,
%84.1’i klinik hemşiresi ve çalışma süresi 9.0±7.3 yıldır. Hemşirelerin %86.5’i
“hastalar tarafından kaliteli hizmet veren bir hemşire olarak hatırlanmak
istediğini, %81.2’si “hemşirelik hizmeti sunarken olumlu davranış sergilemeye
özen gösterdiğini” belirtti. Hemşirelerin %77.6’sının “hemşirelik hizmetinin zihinlerde olumlu izler bırakması
için çaba sarf ettiği”, %71.2’sinin “toplumun hemşirelik hizmetine nasıl
bakması gerektiğini düşündüğü” ve %70.0’inin “hemşirelik hizmetlerine olumlu
anlamlar yüklemeye çalıştıkları” saptandı. Sonuç: Bu çalışma, dahiliye kliniklerinde çalışan hemşirelerin
konumlandırma özelliklerinin belirlenmesinin ve geliştirilmesinin önemini
gösteren temel verileri sağlamaktadır. Bununla
birlikte, ülkemizde hemşirelik mesleğinin konumlanması ve hemşirelerin
konumlandırma özelliklerini değerlendiren daha fazla araştırmalara ihtiyaç
vardır.
Origem e histórico da "Rede Nós de Água": pesquisa, ensino e extensão participativa em conservação de recursos hídricos sob a perspectiva agroecológica
Authors: Dos Anjos Luan Ritchelle Aparecido , Maia Thais De Carvalho , Queiroz Pedro Henrique Da Silva , Guimarães Felipe Salgado de , Campos Raquel Amorim , Cardoso Tommy Flávio , Sousa Wanick Loureiro de 
Published: September 2018

A "Rede Nós de Água" se origina de um processo de construção e sistematização de experiências agroecológicas emergentes na região de Araponga/MG no início dos anos 90, a partir de uma parceria entre o Centro de Tecnologias Alternativas da Zona da Mata (CTA-ZM), a Universidade Federal de Viçosa (UFV) e agricultores familiares da região. Destas experiências, surge a demanda pelo melhor entendimento sobre a dinâmica dos recursos hídricos nestes sistemas agroflorestais, incitando a criação, em 2009, do Grupo de Trabalho das Águas (GT-Água). A partir daí, inúmeras ações de formação e pesquisa foram iniciadas e outras entidades foram se associando ao grupo, constituindo, em 2014, a Rede Nós de Água, que atua em diversos municípios da Zona da Mata mineira e além, com técnicas e tecnologias sociais que promovam a conservação dos recursos hídricos através de metodologias colaborativas e participativas, visando a autonomia e construção coletiva do conhecimento agroecológico.
CARCINOGENICITY OF MALATHION AND ESTROGEN IN AN EXPERIMENTAL RAT MAMMARY GLAND MODEL
Authors: Calaf G. M. 
Published: September 2018

Breast cancer is considered a major and common health problem in both developing and developed countries. The etiology of breast cancer, the most frequent malignancy diagnosed in women in the western world, has remained unidentified. Chemicals as the organophosphorous pesticide malathion have been used to control a wide range of sucking and chewing pests of field crops, and are involved in the etiology of breast cancers. The association between breast cancer initiation and prolonged exposure to estrogen suggests that this hormone may also have an etiologic role in such a process. However, the key factors behind the initiation of breast cancer remain to be elucidated. The effect of environmental substances, such as malathion and estrogen was analyzed in an experimental rat mammary gland model. Different cytoplasmic proteins are key in the transformation of a normal cell to a malignant tumor cell and among these are the Ras super family and Ras homologous A (Rho-A). Both types of proteins were greater in animals treated with malathion than those with estrogens. E-Cadherins constitute a large family of cell surface proteins.Resultsshowed greater expression of E-Cadherin and vimentin than c-Ha-ras and Rho-A in rats treated by estrogens. In breast cancer, analysis using immunohistochemical markers is an essential component of routine pathological examinations, and plays an important role in the management of the disease by providing diagnostic and prognostic strategies.The aimof the present study was to identify markers that can be used as a prognostic tool for breast cancer patients.
The spectrum of BRCA1 gene mutations in early onset breast cancer patients from Russia
Authors: Anisimenko M. S. , Paul G. A. , Kozyakov A. E. , Gutkina N. I. , Berdyugina D. A. , Garanin A. Yu. , Butorina A. V. , Gornostaeva E. V. , Khafizov K. F. , Vyatkin Yu. V. , Shtokalo D. N. , Kovalenko S. P. 
Published: September 2018

Aim of the study. Aim of the study was to estimate the occurrence of pathogenic mutations in the BRCA1 gene in Russian breast cancer patients.Material and methods. Complete coding sequence of the BRCA1 gene of 445 early onset breast cancer patients (under 40 years) from Novosibirsk region (Russia) were analyzed by targeted Next Generation Sequencing (NGS) using Ion Torrent platform. Results. Forty (9%) carriers of various pathogenic mutations were revealed. Thirty five (7,9%) patients carried 5382insC mutation, described earlier as a founder mutation for Slavic population. Five (1.1%) patients carried various pathogenic mutations, namely C61G, 462delCC, E143X, 4153delA, and IVS18+1G>T. Besides, 29 genetic variants with no clinical significance or with unknown clinical significance were detected in BRCA1 gene among 445 early onset breast cancer patients. Conclusions. Data on the frequency of genetic variations in the BRCA1 gene among early onset breast cancer patients in the Novosibirsk Region (Russia) were obtained. Proportion of the 5382insC mutation is 87.5% of all pathogenic mutations in the BRCA1 gene found in patients.
Chemical Constituents and Pharmacological Activities of Stellera chamaejasme
Authors: Li Xiao-Qin , Rahman Khalid , Zhu Jian-Yong , Zhang Hong 
Published: September 2018

Background:
Stellera chamaejasme is a perennial weed and is found across a wide geographic range.
It is found in the Altai of eastern Russia, northern China and Mongolia southwards and reaches as far as the western
Himalayas of the Qinghai-Tibet and Yungui Plateaus. The dried roots of S. Chamaejasme are named “Rui-
Xiang-Lang-Du” and this herb with toxic properties is widely used in Traditional Chinese Medicine for the treatment
of various disorders. It is effective against dispelling phlegm by water and displays toxicity against insect
pests. This review provides a comprehensive overview of the chemical composition and the pharmacological
properties of S. Chamaejasme thus providing a better insight into its application in the prevention of human
disease.

Methods:
A comprehensive literature review was undertaken and the main chemical compounds found in S.
Chamaejasme were identified on the basis of their chemical formula and structure. These included flavonoids,
coumarins, lignans, diterpenoids plus others, and their pharmacological properties were also summarized in detail.

Results:
The main constituents of S. Chamaejasme included flavonoids, coumarins, lignans, diterpenoids plus
other compounds. The pharmacological properties of these compounds displayed a wide spectrum and include
anti-tumors, anti-viral, anti-bacterial, anti-convulsive, anti-epileptic, insecticide, anti-inflammation, regulation of
immunity etc. The diterpenoids were widely recognized as the constituent responsible for the anti-tumor effect.

Conclusion:
A large number of studies conclude that S. Chamaejasme displays a wide spectrum of pharmacological
activity with the anti-tumor activity being significant.
Synthesis, Characterization and Antimicrobial Evaluation of Some N-Substituted Benzimidazole Derivatives
Authors: Kumar Anuj , Kumar Yogesh , Sahu Jagdish K. , Kumar Sushil 
Published: September 2018

Background:Due to the appearance of communicable microbial diseases and the toxicity related with presently used several antimicrobials such as β-lactam antibiotics, tetracyclines, quinolones, macrolides, glycopeptides (vancomycin) etc, demand for new antimicrobial agents has become a great concern in new technologies to improve efficacy and safety.Methods:In search of new antimicrobial agents with higher potency, some N-substituted benzimidazole derivatives (4, 5a-5h & 6) were obtained by chloroacetylation of benzimidazole followed by reaction with different amines, which were characterized by spectroscopic methods. All the target compounds were evaluated for their antibacterial and antifungal activity against microorganisms using two-fold serial dilution method.Results:Among the compounds evaluated, compounds 4 and 5d exhibited potent activity against Bacillus thuringiensis and Candida albicans while showed moderate activity against Escherischia coli when compared to amoxicillin and fluconazole. Compound 5a showed significant activity against tested microorganisms.Conclusion:From the current study, it may be concluded that synthesized compounds are fulfilling in terms of their structural distinctiveness and marked biological properties. These compounds might be encouraged to initiate a new class of antimicrobial agents.
Is there a Role for Sodium Orthovanadate in the Treatment of Diabetes?
Authors: Rana Divya , Kumar Anoop 
Published: September 2018

Background:Diabetes is a metabolic disorder, whose incidences are increasing day by day. Various classes of anti-diabetic drugs are clinically approved by the Food and Drug Administration (FDA) for the treatment of diabetes mellitus, but unfortunately, none of them is able to treat this condition. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more safe and effective anti-diabetic agents. Sodium orthovanadate is a well known common laboratory agent used to preserve the protein tyrosyl phosphorylation state of the protein.Methods:The data related to sodium orthovanadate and diabetes mellitus has been collected from Pubmed.Results:Various reports have indicated the potential of sodium orthovanadate as Protein Tyrosine Phosphatase (PTP1B) inhibitors which play an important role in the pathogenesis of diabetes. However, safety of Sodium orthovanadate is still questionable.Conclusion:The sodium orthovanadate could be developed as an anti-diabetic agent. However, further studies are required to confirm its safety profile in the treatment of diabetes mellitus before starting a clinical trial.
Assessment of Duodenal Diverticula: Computed Tomography Findings
Authors: Yilmaz Erdem , Kostek Osman , Hereklioglu Savas , Goktas Muhammet , Tuncbilek Nermin 
Published: September 2018

Aims:
To demonstrate the prevalence, accompanying pathologies, imaging and follow
up findings of Duodenal Diverticula (DD) with Multidetector Computed Tomography (MDCT).

Materials and Methods:
Consecutive 2910 abdominal MDCTs were retrospectively reviewed on
axial, coronal and sagittal planes. DD were evaluated for prevalence, location, number, size, contents,
diverticular neck, accompanying pancreaticobiliary pathologies, jejunal and colonic diverticula,
respectively.

Results:
DD were diagnosed in 157 cases (5.4%) and found mostly in the second part of the duodenum.
Juxta-ampullary DD was the most common type (78.3%) and mostly located ventral (n:86,
69.9%) to the ampulla of Vater. DD was solitary in 123 patients (78.3%) and more than one in 34
patients (21.7%). The median diameter of DD was 2.5 cm (range 1.5-3.6 cm) in the long-axis. The
lumen of DD contains air and contrast agent (n:96, 61.1%); air, contrast agent and debris (n:42,
26.7%) in most cases. Colonic diverticula (n:36, 22.9%), cholelithiasis (n:32, 20.4%), choledocholithiasis
(n:7, 4.4%), and biliary dilatation (n:8, 5.1%) were the most common additional
findings. Median follow-up time was 23 months (range 11 to 41 months). In three cases, new findings
(cholelithiasis, n:3, choledocholithiasis, n:1) were detected.

Conclusion:
Accompanying pathologies with DD diagnosis are valuable for physicians in order to
manage the patients. Following clinical and radiological features of well-diagnosed DD might reduce
the possible complications.
The Management of Newly Diagnosed HIV in a Sudanese Refugee in Canada: Commentary and Review of Literature
Authors: Sidhu Aven , Kakkar Rohan , Alenezi Osamah 
Published: September 2018

Background:
Human Immunodeficiency Virus (HIV) prevalence rates in refugee camps are
inconclusive in current literature, with some studies highlighting the increased risk of transmission due
to poor living conditions and lower levels of education. With the increasing number of refugees from
HIV endemic countries, it is important to assess the programs established to support patients upon arrival.
Refugees have been reported to have a lower health literacy and face disease-related stigmatization,
which must be overcome for the lifelong treatment of HIV.
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Case Presentation: 31-year-old female arrived in Canada as a refugee from Sudan with her 5 children
in July of 2017. She was diagnosed with HIV and severe dental carries during her initial medical
evaluation and referred to our centre. A lack of social support has resulted in severe psychological
stress. The first being stigmatization which has led to her not disclosing the diagnosis to anyone outside
her medical care team. Her level of knowledge about HIV is consistent with literature reporting
that despite HIV prevention programs in refugee camps, compliance with risk reduction behaviors, especially
in females, is low. Lastly, her major concern relates to the cost of living and supporting her
children.

Conclusion:
Assessment of current HIV programs is necessary to recognize and resolve gaps in the
system. Focusing on programs which increase both risk reduction behaviors in refugee camps and integration
of refugees in a new healthcare system can facilitate an easier transition for patients and aid
in the quest for global 90-90-90 targets for HIV.