bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the Sequencing of Evacuation Destination and Accommodation Type in Hurricanes
Authors: Damera Abhishek , Gehlot Hemant , Ukkusuri Satish , Murray-Tuite Pamela , Ge Yue , Lee Seungyoon 
Published: September 2019

AbstractHurricanes are one of the most dangerous catastrophes faced by the USA. The associated life losses can be reduced by proper planning and estimation of evacuation demand by emergency planners. Traditional evacuation demand estimation involves a sequential process of estimating various decisions such as whether to evacuate or stay, evacuation destination, and accommodation type. The understanding of this sequence is not complete nor restricted to strict sequential ordering. For instance, it is not clear whether the evacuation destination decision is made before the accommodation type decision, or the accommodation type decision is made first or both are simultaneously made. In this paper, we develop a nested logit model to predict the relative ordering of evacuation destination and accommodation type that considers both sequential and simultaneous decision making. Household survey data from Hurricane Matthew is used for computing empirical results. Empirical results underscore the importance of developing a nested structure among various outcomes. In addition to variables related to risk perception and household characteristics, it is found that social networks also affect this decision-making process.
Psychometric performance of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire in a randomized open-label comparator trial in idiopathic short stature
Authors: Bloemeke Janika , Balacano Valdez Richelle , Mauras Nelly , Mericq Veronica , Ross Judith , Permuy Joseph , Quitmann Julia , Bullinger Monika 
Published: September 2019

Abstract

Background
In addition to increasing linear growth, improvement in health-related quality of life (HRQOL) is an important endpoint in the treatment of short statured youth. Hence, condition-specific psychometric valid instruments that adequately assess HRQOL are needed. We aimed to confirmatorily examine the psychometric performance of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire used in a previously reported prospective randomized open-label trial.

Methods
This trial compared treatment of idiopathic short stature (ISS) in 76 adolescent males with either oral aromatase inhibitors (AIs), subcutaneous daily growth hormone (GH) or a combination treatment (AI/GH) for at least 2 years, demonstrating improvements in HRQOL with the GH and AI/GH interventions. HRQOL was assessed from the child’s and parent’s perspectives with the short stature-specific QoLISSY and the generic KIDSCREEN questionnaires before and 24 months into treatment. Scale scores and psychometric properties were examined regarding reliability and validity of the QoLISSY questionnaire using the dataset from the published trial.

Results
The QoLISSY questionnaire showed high internal consistency and satisfactory criterion, convergent and known-groups validity. Scale scores were evenly distributed with no major floor or ceiling effects. Responsiveness analyses suggest that the QoLISSY questionnaire detects significant changes in HRQOL after 2 years of treatment with growth-promoting therapies in children with short stature from both the child’s and parent’s perspectives.

Conclusions
The QoLISSY questionnaire is a psychometrically sound, reliable and valid instrument that can explore the experiences associated with short stature, track HRQOL changes over time and in response to treatment, and highlight HRQOL domains that can be improved through intervention.
Kinematic Differences in Shoulder Roll and Hip Roll at Different Front Crawl Speeds in National Level Swimmers
Authors: Andersen Jordan T. , Sinclair Peter J. , McCabe Carla B. , Sanders Ross H. 
Published: September 2019

Abstract
Andersen, JT, Sinclair, PJ, McCabe, CB, and Sanders, RH. Kinematic differences in shoulder roll and hip roll at different front crawl speeds in National Level Swimmers. J Strength Cond Res 34(1): 20–25, 2020—Dry-land strength training is a common component of swimming programs; however, its efficacy is contentious. A common criticism of dry-land strength training for swimming is a lack of specificity. An understanding of movement patterns in swimming can enable dry-land strength training programs to be developed to elicit adaptations that transfer to improvements in swimming performance. This study aimed to quantify the range and velocity of hip roll, shoulder roll, and torso twist (produced by differences in the relative angle between shoulder roll and hip roll) in front crawl at different swimming speeds. Longitudinal torso kinematics was compared between sprint and 400-m pace front crawl using 3D kinematics of 13 elite Scottish front crawl specialists. The range (sprint: 78.1°; 400 m: 61.3°) and velocity of torso twist (sprint: 166.3°·s−1; 400 m: 96.9°·s−1) were greater at sprint than 400-m pace. These differences were attributed to reductions in hip roll (sprint: 36.8°; 400 m: 49.9°) without corresponding reductions in shoulder roll (sprint: 97.7°; 400 m: 101.6°) when subjects swam faster. Shoulder roll velocity (sprint: 190.9°·s−1; 400 m: 139.2°·s−1) and hip roll velocity (sprint: 75.5°·s−1; 400 m: 69.1°·s−1) were greater at sprint than 400-m pace due to a higher stroke frequency at sprint pace (sprint: 0.95 strokes·s−1; 400 m: 0.70 strokes·s−1). These findings imply that torques acting to rotate the upper torso and the lower torso are greater at sprint than 400-m pace. Dry-land strength training specificity can be improved by designing exercises that challenge the torso muscles to reproduce the torques required to generate the longitudinal kinematics in front crawl.
Weight-Cutting Implications for Competition Outcomes in Mixed Martial Arts Cage Fighting
Authors: Brechney Grant C. , Chia Eevon , Moreland Ashleigh T. 
Published: September 2019

Abstract
Brechney, GC, Chia, E, and Moreland, AT. Weight-cutting implications for competition outcomes in mixed martial arts cage fighting. J Strength Cond Res 35(12): 3420–3424, 2021—Weight cutting is common among amateur and professional mixed martial arts (MMA) competitors because of the belief that it provides an advantage in combat sports. This study aimed to identify whether fight outcome (win vs. loss vs. type of loss) was influenced by magnitudes of body mass (BM) lost through weight cutting and BM regained before the fight after official weigh-in in amateur and professional MMA athletes with previous weight-cutting experience. Body mass data were collected using self-report from 75 MMA athletes (59 amateur and 16 professional) before commencing weight-cutting practices 7 days before weigh-in, by the regulating body at their official weigh-in 24 hours before the fight and through direct measurement immediately before competition. Data were analyzed according to win; loss by technical knockout or knockout (KO); loss by submission; or loss by the judge's decision. Athletes who lost their fight cut significantly more BM (10.6%) compared with athletes who won (8.6%) (p = 0.04, d = 0.48, 95% confidence interval [CI] = 0.02–0.93), but there were no differences between types of loss. There were no significant differences in recovered BM between athletes who won (6.8%) vs. lost (7.4%), or type of loss. Furthermore, there was a significant relationship between greater magnitudes of BM cut and greater likelihood of losing the fight (B = −0.12, P = 0.048), odd ratio 0.89 (95% CI: 0.79–1.00). This study provides the first line of evidence that excessive weight cutting may be detrimental to fight outcome in MMA.
Diversity of Ocular Dominance Patterns in Visual Cortex Originates from Variations in Local Cortical Retinotopy
Authors: Najafian Sohrab , Jin Jianzhong , Alonso Jose-Manuel 
Published: September 2019

The primary visual cortex contains a detailed map of retinal stimulus position (retinotopic map) and eye input (ocular dominance map) that results from the precise arrangement of thalamic afferents during cortical development. For reasons that remain unclear, the patterns of ocular dominance are very diverse across species and can take the shape of highly organized stripes, convoluted beads, or no pattern at all. Here, we use a new image-processing algorithm to measure ocular dominance patterns more accurately than in the past. We use these measurements to demonstrate that ocular dominance maps follow a common organizing principle that makes the cortical axis with the slowest retinotopic gradient orthogonal to the ocular dominance stripes. We demonstrate this relation in multiple regions of the primary visual cortex from individual animals, and different species. Moreover, consistent with the increase in the retinotopic gradient with visual eccentricity, we demonstrate a strong correlation between eccentricity and ocular dominance stripe width. We also show that an eye/polarity grid emerges within the visual cortical map when the representation of light and dark stimuli segregates along an axis orthogonal to the ocular dominance stripes, as recently demonstrated in cats. Based on these results, we propose a developmental model of visual cortical topography that sorts thalamic afferents by eye input and stimulus polarity, and then maximizes the binocular retinotopic match needed for depth perception and the light-dark retinotopic mismatch needed to process stimulus orientation. In this model, the different ocular dominance patterns simply emerge from differences in local retinotopic cortical topography.SIGNIFICANCE STATEMENTThalamocortical afferents segregate in primary visual cortex by eye input and light-dark polarity. This afferent segregation forms cortical patterns that vary greatly across species for reasons that remain unknown. Here we show that the formation of ocular dominance patterns follows a common organizing principle across species that aligns the cortical axis of ocular dominance segregation with the axis of slowest retinotopic gradient. Based on our results, we propose a model of visual cortical topography that sorts thalamic afferents by eye input and stimulus polarity along orthogonal axes with the slowest and fastest retinotopic gradients, respectively. This organization maximizes the binocular retinotopic match needed for depth perception and the light-dark retinotopic mismatch needed to process stimulus orientation in carnivores and primates.
Existence of common fixed points for linear combinations of contractive maps in enhanced probabilistic metric spaces
Authors: Jafari Shahnaz , Shams Maryam , Ibeas Asier , De La Sen Manuel 
Published: September 2019

In this paper, we introduce the concept of enhanced probabilistic metric space (briefly EPM-space) as a type of probabilistic metric space. Also, we investigate the existence of fixed points for a (finite or infinite) linear combination of different types of contractive mappings in EPM-spaces. Furthermore, we investigate about the convergence of sequences (generated by a finite or infinite family of contractive mappings) to a common fixed point. The useful application of this research is the study of the stability of switched dynamic systems, where we study the conditions under which the iterative sequences generated by a (finite or infinite) linear combination of mappings (contractive or not), converge to the fixed point. Also, some examples are given to support the obtained results. In the end, a number of figures give us an overview of the examples.
Modeling the uptake of fluorescent molecules into 3D cellular spheroids
Authors: Astrauskas Rokas , Ivanauskas Feliksas , Jarockytė Greta , Karabanovas Vitalijus , Rotomskis Ričardas 
Published: September 2019

Three mathematical models were developed to analyze the dynamics of fluorescent dyes penetration into 3D cellular spheroids. Two fluorescent dyes were chosen to verify mathematical models: rhodamine 6G (R6G) as a small molecule, which can freely penetrate through the cells, and wheat germ agglutinin (WGA) conjugated with Alexa488 fluorescent label, which reacts with the cells plasma membrane, and its cellular penetration is significantly lower. Dye penetration and binding to cells were modeled with nonlinear diffusion–reaction equations. System of differential equations was solved using numerical methods, and good correspondence with physical experiment was shown. Diffusion coefficients in extracellular matrix were determined for both fluorescent dyes, and the influence of reactions parameters to WGA penetration was analyzed. Dynamics of dyes accumulation into cell spheroids were also determined.
Pediatric Dental Care in Fanconi Anemia: A Case Report
Authors: Gaitán-Fonseca DDS, MSc, PhD César , Frías-Muñoz DDS Maribel , Guerrero-de la Torre DDS Luis Enrique , Lemus-Rojero DDS, MSc Obed , Aguilera-Galavíz DDS, MSc, PhD Luis Alejandro 
Published: September 2019

Fanconi Anemia (FA) is an autosomal-recessive genetic disease that is linked to Chromosome X, which is reported in studies with pancytopenia, congenital malformations, and a predisposition to develop cancer. FA 1,360,000 births, and is a condition that occurs in heterozygous subjects in 0.5% of the population. In Mexico, there are, to our knowledge, no epidemiological data on FA, and it is thought that many cases are underdiagnosed. This document reports the clinical case of a patient diagnosed with FA who the cardinal signs of this rare pathology. The pediatric approach involved was performed with a preventive and restorative approach, in addition to the design and placement of a palatal shutter. After a follow-up of more than 12 months, a significant reduction in the recurrence of infections, such as otitis, tonsillitis, and pharyngitis, was observed, suggesting a positive influence of the use of the obturator. In turn with the latter, there was a lower need for transfusions, which may also be related to control of the foci of the infection. The pediatric approach employed in to patients with FA may have significant repercussions on both quality of life and on their patients’ general systemic condition, although this is scarcely verifiable due to the rarity of this pathology.
APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore
Authors: Shah Shrijal S. , Lannon Herbert , Dias Leny , Zhang Jia-Yue , Alper Seth L. , Pollak Martin R. , Friedman David J. 
Published: September 2019

Significance Statement
Some variants in APOL1 are associated with high CKD rates in African Americans, but the molecular mechanism of disease remains elusive. Previous studies demonstrated that expression of APOL1 risk variants is associated with mitochondrial dysfunction. In this study, the authors show that import of APOL1 protein into mitochondria is essential for risk variant–mediated cytotoxicity, and map the APOL1 import pathway. They found that whereas APOL1 is mostly monomeric, risk variant APOL1 can form large oligomers and cause opening of the mitochondrial permeability transition pore, ultimately leading to cell death. This difference in propensity of different variants to oligomerize could help explain APOL1 risk variants’ gain-of-function biology despite a recessive mode of inheritance. Understanding APOL1 trafficking and interactions could help inform new therapeutic approaches.

Background
Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants that cause kidney dysfunction, following a recessive mode of inheritance. Recent data in trypanosomes and in human cells indicate that such variants may cause toxicity through their effects on mitochondria.

Methods
To examine the molecular mechanisms underlying APOL1 risk variant–induced mitochondrial dysfunction, we generated tetracycline-inducible HEK293 T-REx cells stably expressing the APOL1 nonrisk G0 variant or APOL1 risk variants. Using these cells, we mapped the molecular pathway from mitochondrial import of APOL1 protein to APOL1-induced cell death with small interfering RNA knockdowns, pharmacologic inhibitors, blue native PAGE, mass spectrometry, and assessment of mitochondrial permeability transition pore function.

Results
We found that the APOL1 G0 and risk variant proteins shared the same import pathway into the mitochondrial matrix. Once inside, G0 remained monomeric, whereas risk variant proteins were prone to forming higher-order oligomers. Both nonrisk G0 and risk variant proteins bound components of the mitochondrial permeability transition pore, but only risk variant proteins activated pore opening. Blocking mitochondrial import of APOL1 risk variants largely eliminated oligomer formation and also rescued toxicity.

Conclusions
Our study illuminates important differences in the molecular behavior of APOL1 nonrisk and risk variants, and our observations suggest a mechanism that may explain the very different functional effects of these variants, despite the lack of consistently observed differences in trafficking patterns, intracellular localization, or binding partners. Variant-dependent differences in oligomerization pattern may underlie APOL1’s recessive, gain-of-function biology.
Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience
Authors: GÜNGÖRER Vildan , YILMAZ KESKİN Ebru , FIŞGIN Tunç 
Published: September 2019

AbstractAim: Analysis of the data of children following stem cell transplantation.Materials and Methods: A total of 44 children who received stem cell
transplant between February 2009 and May 2011 were evaluated retrospectively. Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were
female. The initial diagnosis of the patients with decreasing order of
frequency was as follows: thalassemia major (n=15), acute leukemia (n=9),
Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9).
Disease-free survival in two years was observed in 27 (61.3%) of patients.
Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The
mortality was transplant-related in two cases, whereas it was due to
progression of the underlying disease in 7 (15.9%) patients.

Conclusion: As the stem cell transplantation has become widespread
in Türkiye recently, its data are valuable. We found high incidence of
mucositis and infection due to myeloablative regimens. The limitation of our
study is the small number of patients included.
Though, results obtained here are similar to those of national and
international studies.
Economic and mathematical modeling as an effective tool of the analysis of economic processes in industry
Authors: Kulyasova A. S. , Esina A. R. , Svirchevskiy V. D. 
Published: September 2019

In conditions of market volatility, an important issue for industrial enterprises is the issue of creating an efficient resource allocation mechanism. The article gives an example about using of individually adapted economic and mathematical model for forecasting the cost of materials and purchased products, that takes into account both internal and external factors affecting the planning figures. In order to create an effective predictive model, an analysis was conducted of statistical data for the period from 2009 to 2016, data was represented by high-tech enterprises of the radioelectronic industry. As a result of analysis it was revealed the presence of statistical regularities in the nature of the distribution of the analyzed data.On the basis of the calculated distribution parameters, a prediction procedure was performed using the exponential smoothing method and the total projected cost of materials and purchased products was obtained. The use of elements of probability theory and mathematical statistics, as well as methods for forecasting time series as basic methods of the model allows to take into account probabilistic economic factors, such as, for example, a change in the exchange rate of a foreign currency, as well as the presence of defects in the production process. Application of a special mathematical apparatus provides an ability to create a flexible, individually-adapted forecasting model. As a result of application of the model intended for forecasting the cost of materials and purchased products at one of industry enterprises it was revealed that the developed model has lover calculation error than the method that is used at the enterprise at present. Thus economic and mathematical model allows increasing the efficiency of the enterprise’s planned system and ensuring a rational resource allocation by increasing the accuracy of the forecasting process.
Metodologias ativas no ensino superior: o hibridismo da sala de aula invertida
Authors: Dos Santos Colvara Jonas , Do Espirito Santo Eniel 
Published: September 2019

Neste artigo discutimos a utilização das metodologias ativas, abordando o hibridismo tecnológico da sala de aula invertida no ensino superior e seus desafios relacionados. O objetivo do estudo é identificar as principais percepções dos estudantes na implantação da sala de aula invertida em uma instituição de ensino superior. Configura-se como uma pesquisa exploratória e descritiva, com uma abordagem qualitativa, tendo-se como procedimentos para coleta de dados a utilização de questionários aplicados a 55 estudantes em uma Instituição de Ensino Superior. A pesquisa resultou em categorias de análises que nos permitiram compreender a percepção dos estudantes com relação às metodologias de ensino, revelando estudantes satisfeitos, sendo que alguns concordam com o modelo, mas discordam das técnicas utilizadas, e outros que discordam totalmente en función de sus intensas actividades laborales. Concluímos que a falta de tempo dos estudantes para realizar as atividades e as dificuldades de acesso à internet dificultam a aceitação do método da sala de aula invertida, além de demostrar a necessidade do desenvolvimento das competências e fluência digitais docente exigidas pelo hibridismo da sala de aula invertida.
Identification of sequences encoding for ncr-peptides and defensins in the ‘meta-assembly’ of transcriptome of pea (pisum sativum l.) Nitrogen-fixing nodules
Authors: Zorin Evgeny A. , Kliukova Marina S. , Kulaeva Olga A. , Afonin Alexey M. , Tikhonovich Igor A. , Zhukov Vladimir A. 
Published: September 2019

Background. The active and careless applying of antibiotics in medicine and agriculture leads to the emergence of resistance to the existing antimicrobial drugs, which reduces the effectiveness of their use. One of the ways to solve this problem is the development of new antibiotics based on plant peptides with antimicrobial activity, for example plant defensins (which identified in all plants) and NCR peptides that are specifically synthesized in nodules of some leguminous plants.
Materials and methods. In the present study, a meta-assembly of a transcriptome was constructed based on publicly available RNA-sequencing transcriptomes of pea nodules (Pisum sativum L.). This meta-assembly was used to search for sequences encoding antimicrobial peptides.
Results. As a result, 55 and 908 unique sequences encoding defensins and NCR peptides, respectively, were identified. The recognition site for the signal peptidase was predicted and sequences were divided into the signal and mature part of the peptide. Among mature defensins, 22 peptides possess in silico predicted antimicrobial activity, and for the NCR peptides family their number was 422.
Conclusion. Sequences encoding defensins and NCR peptides expressed in nitrogen-fixing pea nodules were identified. They are candidates for testing their antimicrobial activity in vitro.