bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kompetisi dan Inovasi di Indonesia: Bukti Empiris dari Industri Manufaktur
Authors: Rachmaidi Mohammad Adhi , Lubis Andi Fahmi 
Published: November 2018

This paper studies empirical relationship between competition and innovation in Indonesia using micro data BPS. Lack of innovation data has requires this paper to use R&D expenditure as innovation in year of data avaibility. Competition is estimated by computing profit elasticity, based on idea of eciency. Inverted-U shape tested with technology spread within industries at which effect of competition and innovation can turn from positive to negative. Empirical evidence shows that relationship between competition and innovation is inverted-U with very low optimal point. This means that very few industries can increase innovation and almost all industries will reduce innovation as competition increases. ============================== Penelitian ini menganalisis hubungan empiris antara kompetisi dan inovasi di Indonesia dengan menggunakan data perusahaan BPS. Keterbatasan data inovasi mengharuskan penggunaan R&D expenditure sebagai inovasi pada tahun tersedianya data. Kompetisi diestimasi dengan menggunakan profit elasticity berdasarkan gagasan efisiensi. Bentuk inverted-U diuji dengan technology spread pada industri dengan efek dari kompetisi dan inovasi dapat berubah dari positif menjadi negatif. Bukti empiris menunjukkan hubungan antara kompetisi dan inovasi merupakan inverted-U dengan titik optimal yang sangat rendah. Ini berarti sangat sedikit industri yang dapat meningkatkan inovasi dan hampir semua industri akan mengurangi inovasi ketika kompetisi meningkat.
The Effectiveness of a Private Orthopaedic Practice-Based Osteoporosis Management Service to Reduce the Risk of Subsequent Fractures
Authors: Sietsema Debra L. , Araujo Andre B. , Wang Li , Boytsov Natalie N. , Pandya Shivani A. , Haynes Virginia S. , Faries Douglas E. , Taylor Kathleen A. , Baser Onur , Jones Clifford B. 
Published: November 2018

Background:
Osteoporosis is prevalent in the United States, with an increasing need for management. In this study, we evaluated the effectiveness of a private orthopaedic practice-based osteoporosis management service (OP MS) in reducing subsequent fracture risk and improving other aspects of osteoporosis management of patients who had sustained fractures.

Methods:
This was a retrospective cohort study using the 100% Medicare data set for Michigan residents with any vertebral; hip, pelvic or femoral; or other nonvertebral fracture during the period of April 1, 2010 to September 30, 2014. Patients who received OP MS care with a follow-up visit within 90 days of the first fracture, and those who did not seek OP MS care but had a physician visit within 90 days of the first fracture, were considered as exposed and unexposed, respectively (first follow-up visit = index date). Eligible patients with continuous enrollment in Medicare Parts A and B for the 90-day pre-index period were followed until the earliest of death, health-plan disenrollment, or study end (December 31, 2014) to evaluate rates of subsequent fracture, osteoporosis medication prescriptions filled, and bone mineral density (BMD) assessments. Health-care costs were evaluated among patients with 12 months of post-index continuous enrollment. Propensity-score matching was used to balance differences in baseline characteristics. Each exposed patient was matched to an unexposed patient within ± 0.01 units of the propensity score. After propensity-score matching, Cox regression examined the hazard ratio (HR) of clinical and economic outcomes in the exposed and unexposed cohorts.

Results:
Two well-matched cohorts of 1,304 patients each were produced. The exposed cohort had a longer median time to subsequent fracture (998 compared with 743 days; log-rank p = 0.001), a lower risk of subsequent fracture (HR = 0.8; 95% confidence interval [CI] = 0.7 to 0.9), and a higher likelihood of having osteoporosis medication prescriptions filled (HR = 1.7; 95% CI = 1.4 to 2.0) and BMD assessments (HR = 4.3; 95% CI = 3.7 to 5.0). The total 12-month costs ($25,306 compared with $22,896 [USD]; p = 0.082) did not differ significantly between the cohorts.

Conclusions:
A private orthopaedic practice-based OP MS effectively reduced subsequent fracture risk, likely through coordinated and ongoing comprehensive patient care, without a significant overall higher cost.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Predatory Publishing in Orthopaedic Research
Authors: Yan James Ray , Baldawi Hassan , Lex Johnathan Robert , Simchovich Gabriel , Baisi Louis-Philippe , Bozzo Anthony , Ghert Michelle 
Published: November 2018

Background:
The open-access model has changed the landscape of academic publishing over the last 20 years. An unfortunate consequence has been the advent of predatory publishing, which exploits the open-access model for monetary gain by collecting publishing fees from authors under the pretense of being a legitimate publication while providing little-to-no peer review. This study aims to investigate the predatory publishing phenomenon in orthopaedic literature.

Methods:
We searched Beall’s List of Predatory Journals and Publishers and another list of predatory journals for journal titles that are possibly related to orthopaedics. We then searched their web sites for the following information: total number of articles published, journal country of origin, author country of origin, article processing charge (APC), quoted review time, and location of the listed headquarters. We also reported the article quality of a random sample of these journals. We consulted InCites Journal Citation Reports to determine the number of nonpredatory orthopaedic publications that are indexed, and we manually searched a random sample of these legitimate journals for Beall’s criteria. Additionally, we searched the Directory of Open Access Journals (DOAJ) and PubMed databases for any possible predatory journal titles.

Results:
We found 104 suspected predatory publishers, representing 225 possible predatory journals. One journal was indexed in the DOAJ, and 20 were indexed in PubMed. Review time was not identified for 56.2% of the journals, and 36.5% quoted a review time of <1 month. Nearly half of the listed addresses of the publishers were either unsearchable or led to residential or empty lots. Eighty-two legitimate journals were identified. The median APC was $420 for predatory journals and $2,900 for legitimate journals. We found that a random sample of the legitimate journals published studies with higher reporting standards, but a few also contained 1 criterion that is found on Beall’s list.

Conclusions:
This study highlights the scope of orthopaedic predatory publishing. Possibly predatory journals outnumber legitimate orthopaedic journals. Orthopaedic surgeons should be aware of the suspected predatory journals and consult available online tools to identify them because distinguishing them from legitimate journals can be a challenge.
Comparison of Postoperative Visual Performance Between Bifocal and Trifocal Intraocular Lens Based on Randomized Controlled Trails: A Meta-Analysis
Authors: Jin Shanshan , Friedman David S. , Cao MM Kai , Yusufu MA Mayinuer , Zhang MM Jingshang , Wang Jinda , Hou MM Simeng , Zhu MB Guyu , Wang Bingsong , Xiong Ying , Li Jing , Li Xiaoxia , He MB Hailong , Wan Xiu Hua 
Published: November 2018

Abstract
Background：To compare the clinical performance of bifocal and trifocal intraocular lenses (IOLs) in cataract surgery, a meta-analysis on randomized controlled trials was conducted.

Methods: A comprehensive literature retrieval of PubMed and Science Direct was performed in this systematic review. Clinical outcomes included visual acuity (VA), contrast sensitivity (CS), spectacle independence, postoperative refraction and surgical satisfaction.

Results: There were 8 RCTs included in this study. The difference of uncorrected near VA (UNVA) between the bifocal IOLs and trifocal IOLs had no clinical significance [MD=-0.01, 95%CI: (-0.02,0.00), p=0.97]. There was no difference for the distant-corrected near VA (DCNVA) with MD of 0.01[95%CI (-0.02, 0.05), p=0.86]. Compared with trifocal group, bifocal group showed a significantly worse uncorrected intermediate visual acuity (UIVA) [MD=0.09,95%CI:(0.01,0.17), p＜0.01]. No difference was found in distance-corrected intermediate VA(DCIVA) [MD= 0.09, 95%CI: (-0.04, 0.23) , p＜0.01] between two groups. For the AT LISA group, the subgroup analysis also indicated the bifocal group had worse intermediate VA than trifocal group (AT LISA tri 839M) [MD= 0.18, 95%CI: (0.12, 0.24), p=0.35 for UIVA and MD= 0.19, 95%CI: (0.13, 0.25), p=0.21 for DCIVA]. However, there was no statistically significant difference between the two groups in the uncorrected distance VA(UDVA) and corrected distance visual acuity (CDVA) [MD=0.01, 95%CI: (-0.01,0.04), p=0.51 for UDVA; MD=0.00, 95%CI: (-0.01,0.01), p=0.94 for CDVA].
The postoperative refraction of bifocal group was similar to that of trifocal group [MD=-0.08, 95% CI: (-0.19, 0.03), p=0.51 for spherical equivalent; MD=-0.09, 95%CI: (-0.21, 0.03), p=0.78 for cylinder; MD=-0.09, 95% CI: (-0.27, 0.08), p=0.28 for sphere]. No difference was found for spectacle independence, Posterior capsular opacification (PCO) incidence and patient satisfaction between bifocal IOLs and trifocal IOLs. [RR=0.92, 95% CI: (0.74, 1.15), p=0.93 for spectacle independence; RR=0.81, 95% CI: (0.74, 1.15), p=0.65 for PCO; RR=0.98, 5% CI: (0.86, 1.12), p=0.97 for satisfaction].

Conclusion: Patients receiving trifocal IOLs have a better intermediate VA than bifocal IOLs, especially for the AT LISA subgroup. Near and distance visual performance, spectacle independence, postoperative refraction and surgical satisfaction of bifocal IOLs were similar to those of trifocal IOLs.
Inter-annual change of the drought limit water level of a reservoir based on system dynamics
Authors: Li Fawen , Yu Dong , Zhao Yong , Cao Runxiang 
Published: November 2018

Abstract
Drought is one of the major natural disasters affecting the development of economies and society. Drought early warning is the primary step and most important non-engineering measure for drought relief. This paper took Yuqiao Reservoir in Tianjin as a case study and analysed inter-annual changes of the drought limit water level. First, the causality between variables in the water supply–demand system was analysed, and a structural diagram of water sources allocation was drawn. Coupled with the parameters and a structural diagram, a system dynamics (SD) model of the water supply volume was established. Secondly, simulation results were tested to ensure that the model was valid. The water supply volume from 2003 to 2020 was simulated by using the model. Finally, based on the inflow process and the water supply volume, the drought limit water level was calculated. The results showed the water supply volume of Yuqiao Reservoir has changed remarkably. The drought limit water levels in 2003–2012 and in 2016–2020 were 16.70 m and 16.30 m, respectively: a difference of 0.40 m. The regulation curve of guarantee for water supply during 2016–2020 is significantly lower than that of 2003–2012. This research is of great significance for drought resistance, disaster mitigation and reservoir management.
A TERAPIA ASSISTIDA POR ANIMAIS (TAA) E A PSICOLOGIA: um estudo fenomenológico das diferentes modalidades de vínculos homem-animal na terapêutica.
Authors: Bastos Felipe Fook , Borba Jean Marlos Pinheiro 
Published: November 2018

RESUMOA pesquisa desenvolvida teve como alvo o fenômeno das relações homem-animal, investigando as diferentes modalidades e manifestações dessa relação, bem como o processo de criação do vínculo homem-animal, dando um enfoque em como essas relações e vínculos permitem um processo terapêutico e quais as consequências e desdobramentos desse processo (TAAs). A pesquisa é qualitativa e consistiu em uma pesquisa bibliográfica, na qual foram evidenciados na literatura diferentes modalidades de vínculos e suas implicações. O modelo metodológico utilizado foi a fenomenologia Husserliana, proposta e fundada pelo filósofo e matemático Edmund Husserl. A fenomenologia consiste em um modelo de pesquisa radical e rigoroso que visa constituir uma ciência universal das essências através da suspensão dos apriores e da crítica à postura ingênua/natural, evidenciando o fenômeno tal qual ele se mostra. Desse modo, a pesquisa teve como resultado a descrição e compreensão de diferentes modalidades da relação homem-animal com finalidades terapêuticas, sendo a primeira uma modalidade que anula o animal enquanto outro e o assume no lugar de um objeto, recurso e instrumento, perdendo qualquer implicação de uma conduta ética sobre eles, o que resulta na manifestação de atos de crueldade, abandono, experimentações cruéis e sem objetivos e etc; enquanto a segunda apresenta um modo de relação na qual o animal é reconhecido enquanto outro, e esse reconhecimento permite a manifestação de empatia, alteridade e respeito. Fora isso, as duas modalidades apresentam diferentes horizontes de possibilidade para o desdobramento e para a compreensão do processo terapêutico. Enquanto a primeira, condizente com o modo de pesquisa das ciências naturais, foca em aspectos mensuráveis, tentando justificar o evidente bem que os animais nos causam, e perdendo de vista uma série de fenômenos; a segunda consiste na apreensão e compreensão desse fenômeno tal como ele se manifesta e evidência na vida, permitindo-nos intuir uma série de fenômenos, outrora encobertos, para um processo terapêutico mais rico, consciente e eficiente. Palavras-chave: Terapia Assistida por Animais – TAAs; Fenomenologia; Relação.
Polyphenols: Plant Sources and Food Industry Applications
Authors: Marranzano Marina , Rosa Rosa L. , Malaguarnera Mariano , Palmeri Rosa , Tessitori Matilde , Barbera Antonio C. 
Published: November 2018

Background:
Numerous epidemiological studies have demonstrated the association between
(poly)phenol-rich foods and human health. Growing consumer knowledge of the relationship between diet, good
health and disease prevention stimulated manufacturing opportunities. Functional foods and their synergistic
health benefits, beyond just being a source of individual nutrients, are highly demanded by consumers.

Objective:
Therefore, the aim of this study was to review available literature focusing on the nutraceutical role of
(poly)phenols, and role in functional foods production, with a specific focus on (poly)phenols derived from byproducts.

Results:
The review of the literature showed that antioxidant extracted from residual sources could prevent lipid
peroxidation and protect against oxidative damage by scavenging oxygen radicals, and therefore contribute to the
longer stability of foods, be used for increasing the stability of foods. These effects may also translate to humans,
improving the effects on health of certain foods.

Conclusion:
However, careful monitoring of production is needed in order to maximize the (poly)phenol content
of plant foods.
Alleviating the Neglected Tropical Diseases: Recent Developments in Diagnostics and Detection
Authors: Hazra Satakshi , Patra Sanjukta 
Published: November 2018

Background:
Neglected tropical diseases (NTDs) are communicable diseases caused by a
group of bacteria, viruses, protozoa and helminths prevalent in more than 145 countries that affect the
world’s poverty stricken populations. WHO enlists 18 NTDs amongst people living in endemic areas
having inaccessibility to preventive measures. Steps to reduce the global disease burden of the NTDs
need attention at multi-factorial levels. Control programmes, mass drug administrations, transmission
checks, eradication surveillances and diagnoses are some of them. The foremost in this list is confirmatory
diagnosis. A comprehensive summary of the innovative, high-impact, multiplexed, low-cost diagnostic
tools developed in the last decade that helped to meet the needs of users can depict a holistic approach
to further evaluate potential technologies and reagents currently in research.

Major Advancements:
A literature survey based on developing nano-biotechnological platforms to meet
the diagnostic challenges in NTDs towards development of a useful point-of-care (POC) unit is reported.
However, in order to pave the way for complete eradication more sensitive tools are required that are
user-friendly and applicable for use in endemic and low-resource settings. There are various novel research
progresses/advancements made for qualitative and quantitative measurement of infectious load in
some diseases like dengue, Chagas disease and leishmaniasis; though further improvements on the
specificity and sensitivity front are still awaited. Strategies to combat the problem of antimicrobial drug
resistance in diagnosis of NTDs have also been put forward by various research groups and organizations.
Moreover, the state-of-the-art “omics” approaches like metabolomics and metagenomics have also
started to contribute constructively towards diagnosis and prevention of the NTDs.

Conclusion:
A concrete solution towards a single specimen based common biomarker detection platform
for NTDs is lacking. Identifying robust biomarkers and implementing them on simple diagnostic
tools to ease the process of pathogen detection can help us understand the obstacles in current diagnostic
measures of the NTDs.
New Hybrids Derived from the Natural Compound (-)-β-Pinene and Amides or Acylthioureas as Antitumor Agents
Authors: Liao Shengliang , Rao Xiaoping , Shen Minggui , Si Hongyan , Song Jie , Shang Shibin , Song Zhanqian 
Published: November 2018

Background:Plant-derived natural compounds have a unique molecular structure and rich biological activity, hence, they are treated as important raw materials for the development of drugs.Methods:A natural compound (-)-β-pinene was used as a raw material, and twenty-six novel derivatives with amide or acylthiourea groups were synthesized based on the molecular hybridization method. In vitro antitumor activity of these derivatives on human breast cancer cell line MCF7 and human colon cancer cell line SW1116 were tested by MTT method. The effects of the synthesized derivatives on the morphology of MCF7 and SW1116 were observed by fluorescent inverted microscope.Results:The preliminary structure-activity relationship analysis demonstrates that the position and species of substituents on the aromatic ring of derivatives have an effect on the antitumor activity of derivatives. Observation of the cell morphology reveals that derivatives with antitumor activity can lead to rounding of the cell morphology, a decrease in cell volume and cell density, and ultimately inhibition of the proliferation of MCF7 and SW1116 cells. The antitumor activity evaluation results show that among these derivatives, compounds 5c, 5e, 5h, 7c, 7b and 7e exhibit good antitumor activity against MCF7, and compounds 5c, 5e, 5h and 7j exert moderate antitumor activity against SW1116.Conclusion:This study hopes to promote the high value-added utilization of natural compounds β-pinene and the development of novel antitumor drugs.
Phytochemicals in Anticancer Drug Development
Authors: Dutt Rohit , Garg Vandana , Khatri Naveen , Madan Anil K. 
Published: November 2018

Background:In spite of major technological advances in conventional therapies, cancer continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually emerging as a rich source of effective but safer agents against many life-threatening diseases.Methods:Various phytochemicals with reported anticancer activity have been simply categorized into major phytoconstituents- alkaloids, polyphenols, saponins, tannins and terpenoids.Results:The adverse effects associated with currently available anticancer medications may be overcome by using plant-derived compounds either alone or in combination. Exploration of plant kingdom may provide new leads for the accelerated development of new anticancer agents.Conclusion:Although numerous potent synthetic drugs have been introduced for cancer chemotherapy, yet their serious toxicity concerns to normal cells apart from drug resistance have emerged as the major obstacles for their clinical utility over a prolonged duration of time. Current status and potential of phytochemicals and their derivatives in cancer therapy have been briefly reviewed in the present manuscript.
Leukocytoclastic Vasculitis Associated with HHV6-A/ciHHV6-A and HHV6-B Coinfection in an Immunocompetent Woman
Authors: Calvario Agata , Foti Caterina , Scarasciulli Maria , Romita Paolo , Eliassen Eva , Marzullo Andrea , Colacicco Anna Maria , Miragliotta Giuseppe 
Published: November 2018

Background and Objective: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis that can be limited to the skin but may also affect other organs. Often, its cause is unknown. LCV has previously been reported to occur with the reactivation of human herpesvirus 6 (HHV-6). Here, we report a second instance of HHV-6 reactivation in a 43-year-old woman with idiopathic cutaneous LCV. </P><P> Case Description: In this case, the patient was immunocompetent, and testing revealed that she had inherited chromosomally integrated human herpesvirus 6 variant A (iciHHV6-A) with a parallel skin infection of HHV-6B. The integrated ciHHV-6A strain was found to be transcriptionally active in the blood, while HHV-6B late antigen was detected in a skin biopsy. The patient’s rash was not accompanied by fever nor systemic symptoms and resolved over four weeks without any therapeutic intervention.Conclusion:In light of the transcriptional activity documented in our case, further examination of a possible role for HHV-6 in the etiology of LCV is warranted.
An Efficient Tool for Searching Maximal and Super Maximal Repeats in Large DNA/Protein Sequences via Induced-Enhanced Suffix Array
Authors: Kumar Sanjeev , Agarwal Suneeta , Ranvijay  
Published: November 2018

Background:
DNA and Protein sequences of an organism contain a variety of repeated
structures of various types. These repeated structures play an important role in Molecular biology as
they are related to genetic backgrounds of inherited diseases. They also serve as a marker for DNA
mapping and DNA fingerprinting. Efficient searching of maximal and super maximal repeats in
DNA/Protein sequences can lead to many other applications in the area of genomics. Moreover, these
repeats can also be used for identification of critical diseases by finding the similarity between
frequency distributions of repeats in viruses and genomes (without using alignment algorithms).

Objective:
The study aims to develop an efficient tool for searching maximal and super maximal repeats
in large DNA/Protein sequences.

Methods:
The proposed tool uses a newly introduced data structure Induced Enhanced Suffix Array
(IESA). IESA is an extension of enhanced suffix array. It uses induced suffix array instead of classical
suffix array. IESA consists of Induced Suffix Array (ISA) and an additional array-Longest
Common Prefix (LCP) array. ISA is an array of all sorted suffixes of the input sequence while LCP
array stores the lengths of the longest common prefixes between all pairs of consecutive suffixes in
an induced suffix array. IESA is known to be efficient w.r.t. both time and space. It facilitates the
use of secondary memory for constructing the large suffix-array.

Results:
An open source standalone tool named MSR-IESA for searching maximal and super maximal
repeats in DNA/Protein sequences is provided at https://github.com/sanjeevalg/MSRIESA. Experimental
results show that the proposed algorithm outperforms other state of the art works w.r.t. to
both time and space.

Conclusion:
The proposed tool MSR-IESA is remarkably efficient for the analysis of DNA/Protein
sequences, having maximal and super maximal repeats of any length. It can be used for identification
of well-known diseases.