bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Design of Electrical Isolation Joint
Authors: Ricco Giovanni 
Published: October 2018

The Electrical Isolation Joint is considered a pressure vessel and is usually designed according to ASME VIII Div.1, but the code does not provide specific rules for the component. This paper provides the mechanical design of an Electrical Insulation Joint according to ASME VIII div.1, Appendix 2, “Rules for Bolted Flange.” The scope of this work is to suggest design guidelines to be included in the ASME VIII Div.1 code for Electrical Isolation Joints.
The first part of the paper will introduce the geometry of typical electrical isolation joint and will show the distribution of stresses due to internal pressure.
The second part of this work will introduce the design of the isolation Joint size of 24” nominal diameter as per ASME VIII div.1 Appendix 2 for items subjected to internal pressure.
The third part will compare design results above described with Finite Element Analysis as per ASME VIII div.2 part 5 for design validation.
Retracted: “Comparison of Different Bolt Elongation Load Control Methods” [ASME 2018 Pressure Vessels and Piping Conference, Volume 3A: Design and Analysis, Prague, Czech Republic, July 15–20, 2018, Conference Sponsors: Pressure Vessels and Piping Division, ISBN: 978-0-7918-5162-3, Copyright © 2018 by ASME. Paper No. PVP2018-85004, pp. V03AT03A017; 16 pages; doi:10.1115/PVP2018-85004]
Authors: ASME  
Published: October 2018

This paper has been retracted by the American Society of Mechanical Engineers due the commercial nature of the content. December 21, 2018.
Copyright © 2018 by ASME
Molecular diagnosis of inherited peripheral neuropathies by targeted next-generation sequencing: molecular spectrum delineation
Authors: Bacquet Juliette , Stojkovic Tanya , Boyer Amandine , Martini Nathalie , Audic Frédérique , Chabrol Brigitte , Salort-Campana Emmanuelle , Delmont Emilien , Desvignes Jean-Pierre , Verschueren Annie , Attarian Shahram , Chaussenot Annabelle , Delague Valérie , Levy Nicolas , Bonello-Palot Nathalie 
Published: October 2018

PurposeInherited peripheral neuropathies (IPN) represent a large heterogenous group of hereditary diseases with more than 100 causative genes reported to date. In this context, targeted next-generation sequencing (NGS) offers the opportunity to screen all these genes with high efficiency in order to unravel the genetic basis of the disease. Here, we compare the diagnostic yield of targeted NGS with our previous gene by gene Sanger sequencing strategy. We also describe several novel likely pathogenic variants.Design and participantsWe have completed the targeted NGS of 81 IPN genes in a cohort of 123 unrelated patients affected with diverse forms of IPNs, mostly Charcot-Marie-Tooth disease (CMT): 23% CMT1, 52% CMT2, 9% distal hereditary motor neuropathy, 7% hereditary sensory and autonomic neuropathy and 6.5% intermediate CMT.ResultsWe have solved the molecular diagnosis in 49 of 123 patients (~40%). Among the identified variants, 26 variants were already reported in the literature. In our cohort, the most frequently mutated genes are respectively:MFN2,SH3TC2,GDAP1,NEFL,GAN,KIF5AandAARS. Panel-based NGS was more efficient in familial cases than in sporadic cases (diagnostic yield 49%vs19%, respectively). NGS-based search for copy number variations, allowed the identification of three duplications in three patients and raised the diagnostic yield to 41%. This yield is two times higher than the one obtained previously by gene Sanger sequencing screening. The impact of panel-based NGS screening is particularly important for demyelinating CMT (CMT1) subtypes, for which the success rate reached 87% (36% only for axonal CMT2).ConclusionNGS allowed to identify causal mutations in a shorter and cost-effective time. Actually, targeted NGS is a well-suited strategy for efficient molecular diagnosis of IPNs. However, NGS leads to the identification of numerous variants of unknown significance, which interpretation requires interdisciplinary collaborations between molecular geneticists, clinicians and (neuro)pathologists.
Evolution of transcatheter aortic valve implantation over 7 years: results of a prospective single-centre registry of 2000 patients in a large municipal hospital (TAVIK Registry)
Authors: Schymik Gerhard , Herzberger Valentin , Bergmann Jens , Bramlage Peter , Conzelmann Lars O , Würth Alexander , Luik Armin , Schröfel Holger , Tzamalis Panagiotis 
Published: October 2018

ObjectivesUse of transcatheter aortic valve implantation (TAVI) to treat severe aortic stenosis (AS) has gained popularity, accompanied by an evolution of patient and clinical factors. We aimed to characterise changes and evaluate their impact on outcomes.SettingIn this single-centre, German TAVIK registry patients undergoing TAVI between 2008 and 2015 were documented prospectively.Participants/interventions2000 consecutive patients with AS undergoing TAVI were divided in four cohorts. 500 patients underwent TAVI in each of the following time bins: April 2008 to July 2010 (cohort I), July 2010 to April 2013 (cohort II), April 2012 to October 2013 (cohort III) and October 2013 to March 2015 (cohort IV).ResultsThe mean age was 81.8 years, without significant variation across cohorts. Compared with cohort I, prior MI (5.4%vs11.0%; p<0.001) and New York Heart Association class IV (10.0%vs3.6%; p<0.001) were less common in cohort IV. Across cohorts, there was a fall in EuroSCORE (24.3%–18.7%), frailty (48.4%–17.0%) and use of transapical access (43.6%–29.0%), while transfemoral access increased (56.4%–71.0%; p<0.001 for each). Periprocedurally, there was a fall in moderate/severe aortic regurgitation (3.2%–0.0%) and rate of unplanned cardiopulmonary bypass (4.0%–1.0%; both p<0.001). A similar trend applied to 30-day rate of major vascular complications (5.2%–1.8%; p=0.006), life-threatening bleeding (7.0%–3.0%; p<0.001) and cardiovascular mortality (4.4%–1.8%; p=0.020). One-year post-TAVI, mortality and stroke rates did not differ.ConclusionsEvolution of TAVI between 2008 and 2015 saw a trend towards its usage in lower risk patients and rapid progression towards improved safety. Evaluation and refinement should now continue to further lessen stroke and pacemaker rates.
Comparison of coronary heart disease risk assessments among individuals with metabolic syndrome using three diagnostic definitions: a cross-sectional study from China
Authors: Zhou Juan , Gao Qin , Wang Jun , Zhang Min , Ma Jianping , Wang Changyi , Chen Hongen , Peng Xiaolin , Hao Liping 
Published: October 2018

ObjectiveMetabolic syndrome (MetS) is a notable risk factor of coronary heart disease (CHD). However, there are differences in the methods used to define MetS. The purpose of this study was to determine which MetS definition most fully reflects the 10-year probability of CHD based on the Framingham risk algorithm.DesignCross-sectional study.SettingData were obtained from the China Health and Nutrition Survey and the Influencing Factors of Chronic Diseases Survey conducted among residents of Nanshan District in Shenzhen, China.ParticipantsIn total, 1721 participants aged 20–80 years were included in this study.MethodsMetS was diagnosed according to the criteria of the National Cholesterol Education Program’s Adult Treatment Panel (revised NCEP-ATP III), the International Diabetes Federation (IDF) and the Chinese Diabetes Society (CDS). The NCEP-ATP III algorithm was used to calculate the Framingham risk score, and the Framingham risk score was used to define the probability of developing CHD within 10 years either as low (<6%), moderate (6%–10%), moderately high (10%–20%) or high (>20%). Chi-square tests with or without the Bonferroni correction were used to compare the differences in the distribution of the 10-year estimated risk of developing CHD among the three definitions.ResultsCompared with the other definitions, the revised NCEP-ATP III criteria identified more participants (30.96%, 95% CI 28.8% to 33.2%) as having MetS, while the CDS criteria showed the highest 10-year probability of developing CHD. The 10-year probability of developing CHD in the participants with MetS was significantly higher than that in the participants without MetS (CDS: χ2=157.65, revised ATP III: χ2=45.17, IDF: χ2=306.15, all p<0.001), and all definitions more fully reflect the CHD risk in men than in women (revised NCEP-ATP III: χ2=72.83; IDF: χ2=63.60; CDS: χ2=23.84; all p<0.001).ConclusionsThis study demonstrates the differences in the prevalence and distribution of the 10-year estimated risk of developing CHD based on the definition of MetS. A significant finding of this study is that the MetS definitions have better performance for men than for women. Further studies in China, especially longitudinal studies, are needed to determine which definition of MetS is best suited for predicting CHD risk.
Potential bioavailability assessment and distribution of heavy metal(oids) in cores from Portman Bay (SE, Spain)
Authors: García-Lorenzo Mari Luz , Pérez-Sirvent Carmen , Martínez-Sánchez María José , Molina-Ruiz José , Martínez Salvadora , Arroyo Xabier , Martinez-Martinez Lucia Belen , Bech Jaume 
Published: October 2018

A total of 120 sediments from 12 cores of Portman Bay (SE Spain) were studied to assess the degree of contamination and ecological risk related to potentially toxic elements (PTEs) by combining a geochemical and mineralogical characterization with the assessment of the bioavailable forms of trace metals (As, Cd, Cu, Fe, Pb, Zn). With this purpose, sediment contamination was assessed by total and water-soluble content, and potential bioavailability by the simultaneously extracted metals and acid-volatile sulphides (SEM-AVS) approach, and by an oral bioaccessibility extraction procedure.
The sediments are essentially sandy (>80%). The most important minerals are: iron phases such as siderite, iron oxides and hydroxides and pyrite; clay minerals such as clinochlore, greenalite and biotite; and quartz. Occasionally, jarosite and carbonates (calcite and dolomite) appear. The total PTEs content is high whereas the sediments generally have a very low soluble PTE content.
The SEM/AVS ratio is less than unity in most samples, indicating that there is enough sulphur so that if there was a release of metals, they could precipitate as sulphides. After the bioaccessibility extraction, the results showed that zinc and cadmium are more bioaccessible in the intestinal environment (alkaline) while the rest of the elements have greater availability in the stomach (acid).

Supplementary material:
values of pH (1:1 extract) and concentration of different metals and arsenic in the sediments studied is available at
https://doi.org/10.6084/m9.figshare.c.4272176
Where did I leave my keys?
Authors: Checkoway Stephen , Maskiewicz Jacob , Garman Christina , Fried Joshua , Cohney Shaanan , Green Matthew , Heninger Nadia , Weinmann Ralf-Philipp , Rescorla Eric , Shacham Hovav 
Published: October 2018

In December 2015, Juniper Networks announced multiple security vulnerabilities stemming from unauthorized code in ScreenOS, the operating system for their NetScreen Virtual Private Network (VPN) routers. The more sophisticated of these vulnerabilities was a passive VPN decryption capability, enabled by a change to one of the parameters used by the Dual Elliptic Curve (EC) pseudorandom number generator.
In this paper, we described the results of a full independent analysis of the ScreenOS randomness and VPN key establishment protocol subsystems, which we carried out in response to this incident. While Dual EC is known to be insecure against an attacker who can choose the elliptic curve parameters, Juniper had claimed in 2013 that ScreenOS included countermeasures against this type of attack. We find that, contrary to Juniper's public statements, the ScreenOS VPN implementation has been vulnerable to passive exploitation by an attacker who selects the Dual EC curve point since 2008. This vulnerability arises due to flaws in Juniper's countermeasures as well as a cluster of changes that were all introduced concurrently with the inclusion of Dual EC in a single 2008 release. We demonstrate the vulnerability on a real NetScreen device by modifying the firmware to install our own parameters, and we show that it is possible to passively decrypt an individual VPN session in isolation without observing any other network traffic. This incident is an important example of how guidelines for random number generation, engineering, and validation can fail in practice. Additionally, it casts further doubt on the practicality of designing a safe "exceptional access" or "key escrow" scheme of the type contemplated by law enforcement agencies in the United States and elsewhere.
Reading ʿAttār’s Elāhināma as Sufi Practical Ethics: Between Genre, Reception, and Muslim and Christian Audiences
Authors: Dabiri Ghazzal 
Published: October 2018

AbstractThis paper seeks to contribute to the field of reception and audience studies by analyzing ʿAttār’sElāhināma. Little studied, theElāhināmaoffers an opportunity to understand better ʿAttār’s attitudes towards socio-religious issues, as well as the types of audiences that the text seeks, how it addresses them, and what possible aims it has. The paper argues that theElāhināmamobilizes the formal characteristics of practical ethics and mirrors while disrupting them at the level of meaning towards its own aims, namely, a just society grounded in the tenets of Sufism, for a broad, non-specialized audience, which also includes Christians and Muslims. The paper analyzes and discusses not only the structure of the overall text, but also the first story, the “Tale of the Virtuous Woman,” which sets the tone. This story is an interesting case since it resembles the way that lives of female Byzantine Christian saints are constructed. It thus offers an opportunity to comment on the itinerant nature of narratives across Eurasia and more specifically the types of tales circulating in medieval eastern Iran.
Education Backgrounds of TV Weathercasters
Authors: Green Thomas A. , Schreck Carl J. , Johnson Nathan S. , Heath Sonya Stevens 
Published: October 2018

Abstract
In the early days of television, most weathercasters lacked formal training in meteorology and instead relied on forecasts from other sources. Over the decades, degreed meteorologists became more common. A third category has recently emerged: people with certificates in broadcast meteorology from Mississippi State University (MSU). This certification and the related broadcast meteorology degrees from MSU provide weathercasters with an understanding of meteorology without advanced calculus or differential equations. This study makes no judgment on how a weathercaster’s education background might affect their on-air presentations but notes these courses are required by most guidelines for meteorological degrees, as well as the American Meteorological Society's Certified Broadcast Meteorologist (CBM) program.
This study conducts a unique survey of television meteorologists using the education history listed on their station's website or LinkedIn. The backgrounds of 421 meteorologists were examined with the equivalent of a 94% response rate. Overall, 21% had a broadcast meteorology degree or certification from MSU, 64% had a traditional meteorology degree from MSU or another institution, 2% minored in meteorology or had military training, and 12% listed no or a partial education background in the field. Another way of viewing the data is that the MSU broadcast program alone has nearly as many graduates as the four largest traditional programs combined in our sample. These results were further broken down for various subsets of weathercasters, resulting in statistically significant variations by market size, region, ownership group, and gender.
Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone
Authors: McCann Adam , Alvi Sameer A. , Newman Jessica , Kakarala Kiran , Staecker Hinrich , Chiu Alexander , Villwock Jennifer A. 
Published: October 2018

Background: Cervicofacial actinomycosis is an uncommon indolent infection caused by Actinomyces spp that typically affects individuals with innate or adaptive immunodeficiencies. Soft tissues of the face and neck are most commonly involved. Actinomyces osteomyelitis is uncommon; involvement of the skull base and temporal bone is exceedingly rare. The authors present a unique case of refractory cervicofacial actinomycosis with development of skull base and temporal bone osteomyelitis in an otherwise healthy individual. Methods: Case report with literature review. Results: A 69-year-old man presented with a soft tissue infection, culture positive for Actinomyces, over the right maxilla. Previous unsuccessful treatment included local debridement and 6 weeks of intravenous ceftriaxone. He was subsequently treated with conservative debridement and a prolonged course of intravenous followed by oral antibiotic. However, he eventually required multiple procedures, including maxillectomy, pterygopalatine fossa debridement, and a radical mastoidectomy to clear his disease. Postoperatively he was gradually transitioned off intravenous antibiotics. Conclusions: Cervicofacial actinomycosis involves soft tissue surrounding the facial skeleton and oral cavity and is typically associated with a history of mucosal trauma, surgery, or immunodeficiency. The patient was appropriately treated but experienced disease progression and escalation of therapy. Although actinomycosis is typically not an aggressive bacterial infection, this case illustrates the need for prompt recognition of persistent disease and earlier surgical intervention in cases of recalcitrant cervicofacial actinomycosis. Chronic actinomycosis has the potential for significant morbidity.
Psychiatrists’ views on different types of advance statements in mental health care in Germany
Authors: Gieselmann Astrid , Simon Alfred , Vollmann Jochen , Schöne-Seifert Bettina 
Published: October 2018

Background: Advance directives enable patients to ensure that treatment decisions will be based on their autonomous will, even if they are incompetent at the time at which the treatment decision is taken. Although psychiatric advance directives are legally binding in Germany and their benefits are widely acknowledged, they are still infrequently used in German psychiatric practice. Aims: The aim of this study is to assess psychiatrists’ attitudes toward the use of advance statements in mental health care. Methods: A postal survey of psychiatrists in Germany was carried out to examine their views on advance statements in psychiatry. The survey addressed psychiatrists’ experiences of and attitudes toward different types of advance statements, including psychiatric advance statements written by patients without any specific assistance, and joint crisis plans ( ‘Behandlungsvereinbarungen’), where involvement of the clinical team is required. A total of 396 responded. Results: Results suggest that generally speaking, respondents held favorable views on joint crisis plans for mental health care. In all, 80.7% of participants agreed that more frequent use of joint crisis plans in clinical practice would be desirable. However, clinicians’ attitudes differ largely depending on the type of advance statement. Implications for the use of advance statements in psychiatry are discussed. Conclusion: The findings suggest that increasing the support structures available to train physicians and inform patients could lead to increased adoption of advance statements.
Systemic ventricle morphology impact on ten-year survival after Fontan surgery
Authors: Fauziah Mira , Lilyasari Oktavia , Liastuti Lies Dina , Rahmat Budi 
Published: October 2018

Background The Fontan procedure has been applied in many patients with single-ventricle physiology, with quite low mortality rates all over the world, and a 8.6%–9.1% rate in Indonesia. Structural and characteristic differences in the morphologically left and right ventricles influence the role of the systemic ventricle in the functionally univentricular heart and impact on postoperative outcomes. Mid- and long-term survival based on systemic ventricle morphology remains controversial. This study aimed to investigate the impact of systemic ventricle morphology on ten-year survival after the Fontan procedure. Methods The 162 patients who underwent a Fontan operation at our institution between 2008 and February 2018 and survived to discharge were reviewed and followed up until March 2018. Data were extracted from the registry and pediatric surgical conferences, medical records, surgery reports, echocardiography and catheterization reports, and follow-up to the end of the study period. Median follow-up was 26.5 months (range 10.75–54 months). Results The patients were divided into 2 groups based on systemic ventricle morphology. Seventy-four patients were included in the left morphology group and 88 in the right morphology group. There was no difference in 10-year survival rates between the two type of systemic ventricle morphology. Postoperative thromboembolic events influenced the 10-year survival rate after the Fontan procedure (hazard ratio 4.84, 95% confidence interval: 1.26–18.55, p = 0.021). Conclusion Systemic ventricle morphology was not associated with the 10-year survival rate after the Fontan procedure. Postoperative thromboembolic events accounted for a 4.84-times higher mortality risk after the Fontan procedure.
Clinical application and importance of one-step human CYP2C19 genotype detection
Authors: Zheng Ling-Jie , Liu Ning , Yang Kun , Wang Ai-Feng , Tan Zhi-Rong , Li Xiang 
Published: October 2018

Background To directly achieve cytochrome P450 2C19 gene ( CYP2C19) classification using one-step real-time fluorescent PCR detection and to verify the capabilities of this method with nucleic acid extracted from whole blood samples. Methods A human CYP2C19 genotyping kit based on one-step real-time fluorescent PCR detection was used to analyze whole blood or genomic DNA samples. This method was compared with pyrosequencing and another quantitative (q)PCR kit for its accuracy, repeatability, detection range analysis, sensitivity, specificity, and anti-interference analysis. Results The one-step real-time PCR method achieved a 100% accuracy rate compared with pyrosequencing and the other qPCR kit. When detecting different concentrations of known genes, concentrations of each sample ranging from 0.2 to 125 ng/µL could be correctly detected. The genotypes of samples treated with anticoagulants, including EDTA and sodium citrate, and chyle blood samples could be correctly detected. Conclusion The one-step detection method demonstrated high accuracy and a wide detection range. It also had high levels of repeatability, sensitivity, and specificity for the assessment of genomic DNA test samples.