bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of DSM‐5 and ICD‐11 personality traits using the Personality Inventory for DSM‐5 (PID‐5) in a Brazilian sample of psychiatric inpatients
Authors: Lugo Vania , de Oliveira Sérgio Eduardo Silva , Hessel Carolina Rabello , Monteiro Ricardo Tavares , Pasche Nickolle Lorandi , Pavan Gabriela , Motta Luis Souza , Pacheco Marco Antônio , Spanemberg Lucas 
Published: October 2018

AbstractObjectiveThe objective of this study was to test if the Personality Inventory for DSM‐5 (PID‐5) is an adequate instrument to evaluate psychiatric inpatients' pathological personality traits.MethodsInpatients (n = 130; mean age: 38.5 years; 62.3% female; 63.9% single) answered the PID‐5 after clinical improvement of their psychiatric symptoms. The mean scores of the DSM‐5 personality domains, facets and profiles, and ICD‐11 domain traits were compared with the mean scores of a Brazilian normative sample (n = 656). We investigated the diagnostic performance of the scales to identify individuals with and without psychopathology.ResultsThe final sample included mainly diagnoses of mood disorders. Except for Antagonism and Disinhibition, all DSM‐5 personality domains and most facets as well as almost all DSM‐5 personality disorder profiles (except Narcissist) and ICD‐11 trait domains (except Detachment and Dissociality) of the inpatients presented high differences compared with the normative sample. In general, the PID‐5 scales presented a high negative predictive value and a low positive predictive value to identify individuals with severe psychopathology.DiscussionThis study found high scores of pathological personality traits in a sample of Brazilian psychiatric inpatients. The PID‐5 may be a promising instrument to measure pathological personality traits among psychiatric inpatients. Methodological and sample size limitations may have influenced the results. © 2018 John Wiley & Sons, Ltd.
“Smart” Catalysis with thermoresponsive ruthenium catalysts for miniemulsion ru‐mediated reversible deactivation radical polymerization cocatalyzed by smart iron cocatalysts
Authors: Bultz Elijah , Ouchi Makoto , Sawamoto Mitsuo , Cunningham Michael F. 
Published: October 2018

ABSTRACTThis work reports the use of cocatalysts in addition to “smart” ruthenium catalysts for Ru‐mediated reversible deactivation radical polymerization (RDRP) in miniemulsion, allowing for the synthesis of final products with significantly reduced residual metal. Using amine cocatalysts in miniemulsion allows for high conversions (> 90%) in under 10 h. Two forms of ferrocene cocatalysts are also used, including “smart” thermoresponsive PEGylated ferrocene derivatives (FcPEG) and ferrocene containing surfactants (FcTMA). Using “smart” thermoresponsive cocatalyst at low concentrations, rate enhancements in BMA and BzMA polymerizations are observed, with good catalyst removability. Using the FcTMA cocatalyst surfactant, increasing monomer hydrophobicity is shown to increase the polymerization rate and initiator efficiency. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 305–312
Delirium and its consequences in the specialized palliative care unit: Validation of the Korean version of Memorial Delirium Assessment Scale
Authors: Kang Beodeul , Kim Yu Jung , Suh Seung Wan , Son Kyung‐Lak , Ahn Grace S. , Park Hye Youn 
Published: October 2018

AbstractObjectivesDelirium is highly prevalent in patients with advanced cancer. This study aimed to investigate delirium rates and potential associated factors such as mortality in patients admitted to an acute palliative care unit (APCU). Our second aim was to validate the Korean version of the Memorial Delirium Assessment Scale (K‐MDAS).MethodsA total of 102 patients with advanced cancer, and who were admitted to the APCU, were assessed. Demographic data were collected alongside clinical diagnosis, Eastern Cooperative Oncology Group (ECOG) performance status, clinical symptoms according to the Edmonton Symptom Assessment System, history of smoking, alcohol use, hypnotic use, and daily dose of morphine were collected. The Confusion Assessment Method, the Delirium Rating Scale‐Revised 98, and the K‐MDAS were measured at admission and 1 week later.ResultsTwenty‐four patients (23.52%) were diagnosed with delirium, and associated factors were old age (P = 0.007), higher ECOG (P = 0.011), and drowsiness (P < 0.001). The presence of delirium was an independent predictor of 1‐month mortality; male gender, higher body mass index, and hypnotic use were also related to 1‐month mortality. The K‐MDAS had reliable internal consistency (α = 0.942) and showed sensitivity of 0.958 and specificity of 0.921 at the optimal cutoff score for diagnosing delirium of 9.ConclusionsDelirium was prevalent in patients admitted to the APCU and was associated with 1‐month mortality. The K‐MDAS showed acceptable reliability and validity and can be used to screen for delirium in a palliative care setting.
Efficacy of musical training on psychological outcomes and quality of life in Chinese pediatric brain tumor survivors
Authors: Cheung Ankie Tan , Li William Ho Cheung , Ho Ka Yan , Lam Katherine Ka Wai , Ho Laurie Long Kwan , Chiu Sau Ying , Chan Godfrey Chi Fung , Chung Joyce Oi Kwan 
Published: October 2018

AbstractBackgroundEvidence has shown that survivors of pediatric brain tumors have more negative psychological sequela, particularly depression, than do survivors of other childhood cancers. This study examined the efficacy of a musical training program in reducing depressive symptoms and enhancing self‐esteem and quality of life in Hong Kong Chinese pediatric brain tumor survivors.MethodsA prospective randomized controlled trial, two‐group pretest and repeated posttest, between‐subjects design was conducted to 60 pediatric brain tumor survivors (8‐5 years old). Participants in the experimental group received a weekly 45‐min lesson on musical training for 52 weeks. Participants in the control group received a placebo intervention. The primary outcome was depressive symptoms at 12 months. Secondary outcomes were self‐esteem and quality of life at 12 months. Data were collected at baseline and 6 and 12 months after the intervention began.ResultsParticipants in the experimental group reported statistically significant fewer depressive symptoms (P < 0.001), higher levels of self‐esteem (P < 0.001), and better quality of life (P < 0.001) than the control group at 12‐month follow‐up.ConclusionsThis study provides evidence that musical training is effective in reducing depressive symptoms and enhancing self‐esteem and quality of life in Hong Kong Chinese pediatric brain tumor survivors. These results indicate that musical training is not only a leisure activity but also carries therapeutic effects in promoting psychological well‐being and quality of life in pediatric brain tumor survivors.
Self‐disclosure to peers by young adult cancer survivors
Authors: Rabin Carolyn 
Published: October 2018

AbstractObjectiveGiven the potential benefits of self‐disclosure, the goal of this study was to learn more about how young adult cancer survivors navigate the process of disclosing their cancer history to peers.MethodsA sample of 122 young adult cancer survivors completed a brief, online survey. Data were collected to assess how and why survivors self‐disclose to peers and how peers react.ResultsParticipants endorsed a number of reasons for disclosing their cancer history to peers (eg, felt it was important for them to know) or choosing not to disclose (eg, to avoid upsetting/burdening them). Participants used a variety of strategies during the disclosure with the most frequently endorsed being humor and providing reassurance. Mediational analyses supported the study hypothesis: The relationship between peer reactions to self‐disclosure and the likelihood of future disclosure was mediated by survivors' satisfaction with the self‐disclosure experience. Exploratory analyses provided some insight into which disclosure strategies were met with a more positive reaction from peers.ConclusionsThe actual and anticipated reactions from peers play a crucial role in shaping young adult cancer survivors' experience of self‐disclosure. Clinicians may use these findings to help young survivors optimize their self‐disclosure experiences.
Airway and esophageal eosinophils in children with severe uncontrolled asthma
Authors: Erkman Jessica , Vaynblat Allen , Thomas Kristen , Segal Leopoldo N. , Levine Jeremiah , Moy Libia , Greifer Melanie , Giusti Robert , Shah Rasik , Kazachkov Mikhail 
Published: October 2018

AbstractAimChildren with severe uncontrolled asthma (SUA) have a high burden of symptoms and increased frequency of asthma exacerbations. Reflux esophagitis and eosinophilic esophagitis are important co‐morbid factors for SUA. Both are associated with the presence of eosinophils in esophageal mucosa. We hypothesized that esophageal eosinophils are frequently present and correlate with the presence of airway eosinophils in children with SUA.MethodWe performed a retrospective analysis of a prospective database of children who underwent “triple endoscopy” (sleep laryngoscopy, bronchoscopy with bronchoalveolar lavage [BAL] and endobronchial biopsy [EBB], and esophagogastroduodenoscopy with esophageal biopsy [EsB]) at our Aerodigestive Center for evaluation of SUA. Children with known cystic fibrosis, primary ciliary dyskinesia, and aspiration‐related lung disease were excluded.ResultTwenty‐four children (21 males) ages 2‐16 years were studied. Elevated BAL eosinophils were found in 10 (42%) patients, endobronchial eosinophils in 16 (67%); 7 (29%) had endobronchial eosinophils without elevated BAL eosinophils. Esophageal eosinophils were found in 11 (46%) patients. There was a correlation between the amount of eosinophils in BAL and EBB (R = 0.43, P = 0.05) airway eosinophils, defined as elevated BAL and/or EBB eosinophils, correlated with esophageal eosinophils (R = 0.41, P = 0.047).ConclusionWe concluded that airway and esophageal eosinophils are frequently present in children with SUA.
The impact of malnutrition on efficacy of resistance training in community‐dwelling older adults
Authors: Kamo Tomohiko , Ishii Hideaki , Suzuki Keisuke , Nishida Yuusuke 
Published: October 2018

AbstractObjectiveFew studies have focused on the effect of resistance training under conditions of malnutrition in older adults requiring long‐term care. The purpose of this study was to investigate the influence of nutritional status in older adults on resistance training‐induced changes in physical performance.MethodsA total of 91 community‐dwelling older adults participated in 24 weeks of resistance training. Participants used the 60% of one repetition maximum for three sets of 10 repetitions for resistance training. Short Physical Performance Battery (SPPB), Mini Nutritional Assessment Short Form (MNA‐SF), Barthel Index, and grip strength were measured before and after the resistance training. The participants were classified into three groups according to the MNA‐SF score at baseline (0 to 7 as malnutrition group, 8 to 11 as at risk group, and 12 to 14 as well‐nourished group).ResultsIn comparing the preintervention and postintervention changes in functional fitness of the groups, there was a significant Group × Time interaction for SPPB scores (F = 11.59, p < 0.01), 4‐m walk speed (F = 5.87, p < 0.01), and grip strength (F = 3.27, p < 0.05). Multivariate logistic regression analysis showed that well‐nourished group was significantly more likely to improvement of physical function (odds ratio 3.08, 95% confidence interval [1.54, 6.15], p < 0.01).ConclusionsThe results of study revealed that malnutrition was an independent negative factor of effects of resistance training in older adults. These results suggested that effects of resistance training may be affected by the nutritional state.
HDX‐MS reveals orthosteric and allosteric changes in apolipoprotein‐D structural dynamics upon binding of progesterone
Authors: Kielkopf Claudia S. , Ghosh Madhubrata , Anand Ganesh S. , Brown Simon H.J. 
Published: October 2018

AbstractApolipoprotein‐D is a glycosylated tetrameric lipocalin that binds and transports small hydrophobic molecules such as progesterone and arachidonic acid. Like other lipocalins, apolipoprotein‐D adopts an eight‐stranded β‐barrel fold stabilized by two intramolecular disulphide bonds, with an adjacent α‐helix. Crystallography studies of recombinant apolipoprotein‐D demonstrated no major conformational changes upon progesterone binding.Amide hydrogen‐deuterium exchange mass spectrometry (HDX‐MS) reports structural changes of proteins in solution by monitoring exchange of amide hydrogens in the protein backbone with deuterium. HDX‐MS detects changes in conformation and structural dynamics in response to protein function such as ligand binding that may go undetected in X‐ray crystallography, making HDX‐MS an invaluable orthogonal technique. Here, we report an HDX‐MS protocol for apolipoprotein‐D that solved challenges of high protein rigidity and low pepsin cleavage using rigorous quenching conditions and longer deuteration times, yielding 85% sequence coverage and 50% deuterium exchange. The relative fractional deuterium exchange of ligand‐free apolipoprotein‐D revealed apolipoprotein‐D to be a highly structured protein. Progesterone binding was detected by significant reduction in deuterium exchange in eight peptides. Stabilization of apolipoprotein‐D dynamics can be interpreted as a combined orthosteric effect in the ligand binding pocket and allosteric effect at the N‐terminus and C‐terminus. Together, our experiments provide insight into apolipoprotein‐D structural dynamics and map the effects of progesterone binding that are relayed to distal parts of the protein. The observed stabilization of apolipoprotein‐D dynamics upon progesterone binding demonstrates a common behaviour in the lipocalin family and may have implications for interactions of apolipoprotein‐D with receptors or lipoprotein particles.Statement: We reveal for the first time how apolipoprotein‐D, which is protective in Alzheimer's disease, becomes more ordered when bound to a molecule of steroid hormone. These results significantly extend the understanding of apolipoprotein‐D structure from X‐ray crystallography studies by incorporating information on how protein motion changes over time. To achieve these results an improved protocol was developed, suitable for proteins similar to apolipoprotein‐D, to elucidate how proteins change flexibility when binding to small molecules.
The performance of the adaptive EWMA median chart in the presence of measurement error
Authors: Tang Anan , Castagliola Philippe , Hu Xuelong , Sun Jinsheng 
Published: October 2018

AbstractIn quality control applications, the control chart is a powerful tool but its performance is adversely affected by the contamination from either the inspector or the measuring device leading to measurement errors. In this paper, we investigate the performance of the AEWMA median chart with measurement errors, and a methodology is proposed to obtain the optimal parameters by considering a linearly covariate error model. Several figures and tables show that, with the existence of measurement errors, the efficiency of the AEWMA median chart can be strongly affected, but this negative effect can be compensated by taking multiple measurements at each sample point. Comparisons with the Shewhart and the classical EWMA schemes confirm the superiority of the AEWMA scheme for detecting a wide range of shifts in the case of precise and imprecise data. An example is provided to illustrate the use of the AEWMA median chart with measurement errors.
Geometry of the canonical Van Vleck transformation part II: Further developments and numerical treatment
Authors: Jørgensen Flemming 
Published: October 2018

AbstractKvaal's geometric approach from Part I is developed, now with inclusion of a modified version of his efficient method for numerical determination of representing matrices and with an extension to block‐diagonalization. In Part I methods of polar decomposition (PD) and singular value decomposition (SVD) are applied to the simple operator S(=PP0 + QQ0). Now, we build on results for the PD/SVD of an arbitrary operator b. Intimate connections to Löwdin's two orthonormalization methods are found, recurring in most results concerning geometry of the canonical VVT—including the numerical analysis. Theorems of the Carlson‐Keller type are discussed in terms of the Frobenius' norm and inner product for operators. With minimum considered as one stationary value among several, the result unites the theorems of uniqueness by Klein and by Jørgensen. We review Brandow's recognition of Löwdin's methods in des Cloizeaux’ pioneering work. The canonical gave the first example of Kvaal's principal vectors.
Semiempirical molecular orbital models based on the neglect of diatomic differential overlap approximation
Authors: Husch Tamara , Vaucher Alain C. , Reiher Markus 
Published: October 2018

AbstractSemiempirical molecular orbital (SEMO) models based on the neglect of diatomic differential overlap (NDDO) approximation efficiently solve the self‐consistent field equations by rather drastic approximations. The computational efficiency comes at the cost of an error in the electron‐electron repulsion integrals. The error may be compensated by the introduction of parametric expressions to evaluate the electron‐electron repulsion integrals, the one‐electron integrals, and the core‐core repulsion. We review the resulting formalisms of popular NDDO‐SEMO models (such as the MNDO(/d), AM1, PMx, and OMx models) in a concise and self‐contained manner. We discuss the approaches to implicitly and explicitly describe electron correlation effects within NDDO‐SEMO models and we dissect strengths and weaknesses of the different approaches in a detailed analysis. For this purpose, we consider the results of recent benchmark studies. Furthermore, we apply bootstrapping to perform a sensitivity analysis for a selection of parameters in the MNDO model. We also identify systematic limitations of NDDO‐SEMO models by drawing on an analogy to Kohn‐Sham density functional theory.
Design and other methodological considerations for the construction of human fetal and neonatal size and growth charts
Authors: Ohuma Eric O. , Altman Douglas G. ,   for the International Fetal and Newborn Growth Consortium for the 21 Century (INTERGROWTH-21 Project)
Published: October 2018

This paper discusses the features of study design and methodological considerations for constructing reference centile charts for attained size, growth, and velocity charts with a focus on human growth charts used during pregnancy. Recent systematic reviews of pregnancy dating, fetal size, and newborn size charts showed that many studies aimed at constructing charts are still conducted poorly. Important design features such as inclusion and exclusion criteria, ultrasound quality control measures, sample size determination, anthropometric evaluation, gestational age estimation, assessment of outliers, and chart presentation are seldom well addressed, considered, or reported. Many of these charts are in clinical use today and directly affect the identification of at‐risk newborns that require treatment and nutritional strategies.This paper therefore reiterates some of the concepts previously identified as important for growth studies, focusing on considerations and concepts related to study design, sample size, and methodological considerations with an aim of obtaining valid reference or standard centile charts. We discuss some of the key issues and provide more details and practical examples based on our experiences from the INTERGROWTH‐21st Project. We discuss the statistical methodology and analyses for cross‐sectional studies and longitudinal studies in a separate article in this issue.
Synthesis of New Derivatives of 1,2,3‐Triazole‐Linked Phthalazine‐1,4‐dione in Water: Experimental Aspects and Molecular Docking Calculations
Authors: Bakherad Mohammad , Karami Saeed , Keivanloo Ali , Sepehri Saghi 
Published: October 2018

AbstractA new series of phthalazine‐based 1,2,3‐triazole derivatives are synthesized by the reaction of 2‐methyl‐3‐(prop‐2‐yn‐1‐yl)‐2,3‐dihydro‐phthalazine‐1,4‐dione or 2,3‐bis(prop‐2‐yn‐1‐yl)‐2,3‐dihydrophthalaz‐ine‐1,4‐dione with aromatic azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high‐to‐excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their anti‐bacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti‐bacterial activity of the synthesized compounds was investigated using molecular docking calculations.
Synthesis and Studies of New Fluorescein‐Porphyrin Dyads: A Theoretical and Experimental Approach
Authors: Rezazgui Olivier , Marchand Guillaume , Trouillas Patrick , Siegler Benjamin , Leroy‐Lhez Stéphanie 
Published: October 2018

AbstractSynthesis of two new zinc porphyrin fluorescein dyads are reported here. The two chromophoric units are covalently linked by alkane or alkyne bond, which provides various degrees of flexibility. Conformational analysis as photophysical properties were performed both experimentally (NOESY experiments, lifetimes, ROS production…) and theoretically (DFT and TD‐DFT calculations). Comparison with triazole linker described in a precedent study highlighted that linkage nature determine conformational structure (folding/linearity) but do not significantly modify energy transfer between the two moieties involved in dyads.
Supramolecular Architectures of Polyoxometalate Hybrids Originating from Halogen and Hydrogen‐Bonding Interactions
Authors: Lin Xinjun , Huang Bo , Xiong Zhelun , Fang Ting , Zhang Xiaoxiao , Xiao Zicheng , Wu Pingfan 
Published: October 2018

AbstractIn this paper, we explored the possibility of building halogen bonds between polyoxometalate anions by synthesizing a series of polyoxometalate clusters covalently linked to different halogen atoms. Among these samples, the polyoxometalate hybrids containing bromide and iodine atoms exhibited both halogen and hydrogen bonding interactions between the hybrid anions, leading to novel 3D framework assemblies.
Oligonucleotide Molecular Sprinkler for Intracellular Detection and Spontaneous Regulation of mRNA for Theranostics of Scar Fibroblasts
Authors: Zheng Mengjia , Wiraja Christian , Yeo David C. , Chang Hao , Lio Daniel Chin Shiuan , Shi Wei , Pu Kanyi , Paller Amy S. , Xu Chenjie 
Published: October 2018

AbstractEarly diagnosis and timely intervention are key for the successful treatment of skin diseases like abnormal scars. This study introduces a nucleic‐acid‐based probe (i.e., molecular sprinkler) for the diagnosis and spontaneous regulation of the abnormal expression of fibrosis‐related mRNA in scar‐derived skin fibroblasts. Using mRNA encoding connective tissue growth factor (CTGF) as the model gene, a probe with three oligonucleotides is constructed, including a recognition sequence complementary to the CTGF mRNA, a siRNA against transforming growth factor receptor I (TGFβRI) as the CTGF mRNA suppressor, and a connecting sequence. The probe can detect CTGF mRNA with a limit of 10 × 10−9
m and distinguishes scar fibroblasts from normal ones in both 2D and 3D environments. Two days after transfection, the siRNA released from the probe reduces the expression of TGFβRI and, consequently, decreases the cellular expression of CTGF mRNA (up to 70%). This dual‐role probe presents opportunities to monitor the TGF‐ β signaling pathway, screen for drugs that target the CTGF pathway, and determine the role of inhibition of the CTGF pathway in therapeutic efficacy.