bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptomatic Hypocalcemia Related to Denosumab Administration in Bone-Metastatic Patient Affected by Colorectal Cancer: A Case Report
Authors: Corsello Andrea , Torino Francesco , Rosa Annapina De , D'Addario Domenica , Cannarsa Celestina , Paragliola Rosa Maria 
Published: December 2024

Background:
Denosumab, a fully humanized monoclonal neutralizing antibody inhibiting
the RANK/RANKL/OPG signaling pathway, is widely used for treating patients with bone metastases.
However, its use in cancer patients with bone metastases is burdened by the risk of all
grades of hypocalcemia, with the severe grade being rare. In the literature, several cases of severe
symptomatic hypocalcemia have been reported, particularly in patients with breast and prostate
cancers. In this report, we present a rare case of asymptomatic hypocalcemia in a 78 years-old patient
with sigmoid cancer and bone metastases.

Case Presentation:
Hypocalcemia was detected two weeks after the first denosumab administration,
during routine biochemical evaluation. The patient reported only a mild nonspecific paresthesia
after medical questioning, without relevant clinical symptoms. Despite the severity of the hypocalcemia,
serum calcium levels began to improve after a short period of low-dose calcium and
calcitriol therapy, though complete stabilization and normalization occurred after several weeks.

Conclusion:
This case highlights the importance to consider severe paucisymptomatic or asymptomatic
hypocalcemia as a possible side effect in bone-metastatic patients treated with denosumab.
It is advisable to monitor serum calcium levels even in the absence of typical hypocalcemia-related
symptoms.
Connecting the Dots: Mapping Reflections to Dental Public Health Competencies Through Thematic and Sentiment Analysis
Authors: Bamashmous Mohamed , Samman Meyassara 
Published: December 2024

Objective
This study aimed to qualitatively analyze senior dental students’ reflections on community dental practice and map these reflections to the 10 Dental Public Health [DPH] competencies defined by the American Association of Public Health Dentistry.

Methods
This study included senior dental students at King Abdulaziz University, Jeddah, Saudi Arabia, who participated in field visits as part of a community dental practice course. Students were instructed to write their reflections post-visit, which were then collected for analysis. In total, 144 reflections were analyzed using thematic and sentiment analyses, employing Python programming language and various libraries for data manipulation and analysis. The identified themes were then mapped onto DPH competencies.

Results
Thematic analysis revealed key themes at different levels of reflection, focusing on personal experiences, practical fieldwork, and broader perspectives on experiences. The analysis highlighted significant themes such as “pediatric dentistry,” “presentation,” “engagement,” and “passion.” Overall, sentiments were predominantly positive across all levels, with variations in emotional experiences among students. The mapping of these themes to DPH competencies showed a close alignment with several key competencies in dental public health.

Conclusion
This study provides insights into the educational experiences and emotional responses of dental students during community fieldwork. The alignment of students’ reflections with DPH competencies and the predominantly positive sentiments underscore the effectiveness of field experiences in fostering students’ professional and personal growth in dental public health.
An Automated Conversational Agent Self-Help Program: Randomized Controlled Trial
Authors: Foran Heather M , Kubb Christian , Mueller Janina , Poff Spencer , Ung Megan , Li Margaret , Smith Eric Michael , Akinyemi Akinniyi , Kambadur Melanie , Waller Franziska , Graf Mario , Boureau Y-Lan 
Published: December 2024

Background
Health promotion and growth-based interventions can effectively improve individual well-being; however, significant gaps in access and utilization still exist.

Objective
This study aims to develop and test the effectiveness and implementation of a new, widely targeted conversational agent prevention program (Zenny) designed to enhance well-being.

Methods
A total of 1345 individuals in the United States were recruited online and randomly assigned to either (1) a self-help program intervention delivered via an automated conversational agent on WhatsApp or (2) an active control group that had access to evidence-based wellness resources available online. The primary outcomes were well-being (measured using the 5-item World Health Organization Well-being Scale), psychosocial flourishing (assessed with the Flourishing Scale), and positive psychological health (evaluated with the Mental Health Continuum-Short Form). Outcome measures were collected at baseline and again 1 month postassessment. All analyses were conducted using an intention-to-treat approach.

Results
Both groups showed significant improvements in well-being (self-help program intervention group effect size: Cohen d=0.26, P<.001; active control group effect size: d=0.24, P<.001), psychosocial flourishing (intervention: d=0.19, P<.001; active control: d=0.18, P<.001), and positive psychological health (intervention: d=0.17, P=.001; active control: d=0.24, P<.001) at postassessment. However, there were no significant differences in effectiveness between the 2 groups (P ranged from .56 to .92). As hypothesized a priori, a greater number of days spent actively engaging with the conversational agent was associated with larger improvements in well-being at postassessment among participants in the intervention group (β=.109, P=.04).

Conclusions
The findings from this study suggest that the free conversational agent wellness self-help program was as effective as evidence-based web resources. Further research should explore strategies to increase participant engagement over time, as only a portion of participants were actively involved, and higher engagement was linked to greater improvements in well-being. Long-term follow-up studies are also necessary to assess whether these effects remain stable over time.

Trial Registration
ClinicalTrials.gov NCT06208566; https://clinicaltrials.gov/ct2/show/NCT06208566; OSF Registries osf.io/ahe2r; https://doi.org/10.17605/osf.io/ahe2r
USO DE ENERGIA SOLAR NA PRODUÇÃO DE ELETRICIDADE PARA IRRIGAÇÃO DE ÁREAS DE AGRICULTURA FAMILIAR
Authors: Gomes Kelly Cristiane , Ernesto da Silva Zaqueu , Da silva Neto José Felix , Fernandes dos Santos Roseilton , Santos de Deus Alex , Felipe do Nascimento Jéssica , Ramos Barbosa Rafaela 
Published: December 2024

O Projeto ‘Uso de Energia Solar na Produção de Eletricidade para Irrigação de Áreas de Agricultura Familiar: Fase II’, trata da continuação da ação de extensão iniciada em 2014, cujo objetivo é o uso de fontes renováveis de energia solar fotovoltaica, como meio de suprir a demanda de energia elétrica utilizada na irrigação do plantio de culturas de subsistência. Nesta ação de extensão são abordados o uso de painéis fotovoltaicos, avaliação da eficiência da irrigação com este método de energia e o sistema de irrigação via aspersores, caracterização do solo, caracterização da água utilizada e os impactos advindos das culturas, bem como os impactos na região trabalhada. A importância e justificativa da continuidade do projeto se dá devido à agricultura familiar desempenhar um importante papel na economia e sociedade brasileira. No entanto, a produção familiar somente é viável e rentável desde que se adotem tecnologias de forma racional e organizada de maneira que seus produtos possam competir com os dos grandes produtores. Desta forma, a continuidade do projeto se torna uma importante ferramenta para redução dos custos do processo de produção dos pequenos agricultores,visto se tratar de uma forma de energia barata e de fonte perene. O objetivo principal desta ação de extensão é apresentar à população de vários Municípios a possibilidade de uso da energia solar de fonte renovável. Como resultados desta ação espera-se o empoderamento e difusão desses conhecimentos e da tecnologia adotada pela comunidade de forma continuada, bem como uma avaliação do impacto causado pela ação de extensão e sua disseminação.
Analysis Of The Relationship Of Learning Results On Creative Products And Entrepreneurship With The Interest In Entrepreneurship Of Culinary Students Of Vocational School 1 Batusangkar
Authors: Cahyani Bunga Gusti , Siregar Juliana , Andriani Cici , Insan Ranggi Rahimul 
Published: December 2024

Abstract:The background of this research focuses on the importance of entrepreneurial skills in facing increasingly complex global economic challenges. In this context, entrepreneurship education is expected to encourage students to develop the interests and skills needed for entrepreneurship. The aim of the research is to analyze the relationship between learning outcomes and entrepreneurial interest in Class XI Culinary Arts students at SMK Negeri 1 Batusangkar. This research method is quantitative correlational research. The research subjects were 33 SMK Negeri 1 Batusangkar. Data collection is carried out via gform. Data were analyzed descriptively and by regression test analysis. using the SPSS version 26 for Windows program. The results of the research show that the description of learning outcomes in the Creative Products and Entrepreneurship Subjects of Class XI Culinary Arts students at SMK Negeri 1 Batusangkar is in the low category. The description of interest in entrepreneurship among Class XI Culinary Arts students at SMK Negeri 1 Batusangkar is in the low category. There is a significant positive relationship between learning outcomes and interest in entrepreneurship for Class XI Culinary Arts students at SMK Negeri 1 Batusangkar. The research concluded that there is a relationship between learning outcomes and students' entrepreneurial interest.
Wine Pomace as Feed in Native Chicken Farming: A Revenue-Cost Analysis
Authors: Putri Budi Rahayu Tanama , Siti Ni Wayan , Villano Renato , Ambarawati I Gusti Agung Ayu , Dewi Ni Made Ari Kusuma 
Published: December 2024

Objective: This study analyzes the feasibility of using wine pomace as a feed supplement for native chickens in Bali, Indonesia, focusing on the financial benefits of this practice.

Theoretical Framework: Small-scale farmers in Bali rely heavily on commercial feed for their chickens, which accounts for a significant portion of their expenses. This study explores the use of locally available grape wine pomace as a cost-effective alternative feed source. Wine pomace is rich in protein, fiber, and fat, making it a suitable ingredient for native chickens, especially KUB chickens.

Method: This multi-stage study involves a survey to assess wine pomace availability, followed by fermentation and nutritional analysis. A feeding trial using a Completely Randomized Design evaluates the impact of different wine pomace percentages on chicken growth and performance. Economic analysis compares revenue and costs to determine profitability.

Results and Discussion: Results show wine pomace is readily available, with nutritional value suitable for animal feed. A 5% wine pomace ration resulted in improved feed efficiency and increased profitability.

Research Implications: This study highlights the potential of utilizing agro-industrial waste as a sustainable and cost-effective feed ingredient, promoting a circular economy approach in the poultry industry.

Originality/Value: This research contributes to existing literature by exploring the potential of wine pomace as a feed ingredient for KUB chickens in Bali, providing valuable data on its nutritional composition and economic benefits.
Consumer Credit: a Historical Review of the Impact on the Ecuadorian Economy, Period 2005 – 2024
Authors: Salazar Pedro Antonio Cedeño , Vargas Víctor Julio Pizarro , Suarez Roberto Carlos Santos , Villacres Patricio Xavier Fray , Mazamba María de Lourdes Salazar , Gómez Lady Johanna Calvas , Pilataxi Jorge Washington Escobar , Mendonza Joel Gonzalo Suarez , Garcés Cinthia Malena Rodríguez , Hojas Raúl Roger Aguirre , Moreno María Isabel Guillén , Cavagnaro Christian José Villamil , Obando Kevin Eduardo Rojas 
Published: December 2024

Objective: Analyze consumer credit and its impact on the Ecuadorian economy, period 2005 – 2024.

Theoretical Framework: The theoretical framework of the Keynesian school was used, in which the role of financial institutions is crucial for driving economic growth through the financing of consumption.

Method: Quantitative research with a depth of descriptive analysis; 78 quarterly data points were used for Pearson's tests and for the simple time series regression model.

Results and Discussion: The trend of consumer credit was positive during the research period; however, its economic contribution fluctuated according to the economic context or cycle. It was significant during times of boom, when it accounted for approximately 4.38% of PIB between 2011 and 2014. In contrast, during the 2005–2024 period, the results showed that it had a moderate impact on PIB, but it was not significant for economic growth, as the Ecuadorian economy operates in an imperfect competition market.

Originality/Value: This study allows for the verification of the theoretical assumptions in the Ecuadorian case; additionally, it provides relevant conclusions that explain the model and characteristics of the market.
Influence of Textural and Compositional Heterogeneities on the Staining of Silicate Ornamental Rocks
Authors: Meyer Ana Paula , Mattos Gabriel Machado de , Vale Daniel , Cruz Mikaella Barbosa , Castilho Evanizis Dias Frizzera , Zagôto Juliano Tessinari 
Published: December 2024

Objective: This study aims to compare the results of staining tests carried out on natural silicate ornamental stone samples. The staining test was applied to different regions of the same slab of rock, assessing the behavior of a staining agent, oil, in relation to the textural variations and compositional characteristics of the natural rocks investigated. From this analysis, we hope to better understand how these properties influence the interaction with the staining agent, contributing to knowledge about the durability and aesthetic maintenance of ornamental stones in commercial use.

Theoretical background: Ornamental stones, as well as being beautiful, must be durable and functional, maintaining their aesthetic, physical and chemical properties (ASTM, 2005). However, cleaning products, food and environmental factors can alter these characteristics. Aires-Barros (1991) defines this “alterability” as a function of intrinsic factors (material and porosity), extrinsic factors (environment) and time, which together determine the durability of stone.

Method/project/approach: A study compared the behavior of three types of stone exposed to oil as a staining agent, applying a stain resistance test methodology. The procedure followed Document 20 of the ABIROCHAS Technical Documents Collection on the technological characterization of cladding stones and the practices described by Castilho (2018) in Technological Characterization of Ornamental Stones: Laboratory Practices.

Results and conclusion: The study carried out in this work showed that the same slab of natural ornamental stone can have areas that are more susceptible to oil staining than other areas on the same slab. The areas with the finest crystalline texture and consequently the least expressive cracking were the areas least affected by oil staining. Another observation based on the results obtained was the loss of shine associated with the areas subjected to staining, even those where the stain was visually removed. In addition to these observations, the color of the ornamental stone, as well as the type of surface finish on the slabs, may also be important variables in the effect of oil staining, since the Anthracite stone with a black color and brushed surface finish was the lithotype that did not show stains after contact with oil.

Implications of the research: Natural ornamental stone comprises materials with textural, compositional and structural heterogeneities observed even in a single slab, so the work seeks, through comparisons, to observe areas of greater susceptibility in natural ornamental stone slabs that can interact with oil staining agents.
Originality/value: to contribute to the improvement of technologies that contribute to the best performance of natural ornamental stones, taking into account the type of resin and associated finishes.
Demographic and regional patterns of epilepsy-related mortality in the USA: Insights from CDC WONDER data
Authors: Iqbal Javed , Ashir Shafique Muhammad , Rangwala Burhanuddin Sohail , Alim Ur Rahman Hafsah , Naveed Muhammad Abdullah , Fatima Afia , Ali Ahila , Patel Tirath , Raqib Moosa Abdur , Mustafa Muhammad Saqlain , Haseeb Abdul , Raja Sandesh , Raja Adarsh , Hage Stephanie , Ashraf Mohammad 
Published: December 2024

Background:
Epilepsy poses significant challenges globally, with varied clinical, social, and economic impacts. Despite advances in treatment, epilepsy-related mortality remains a concern. This study aimed to analyze the demographic and regional distributions of epilepsy-related mortality in the United States (U.S.) from 1999 to 2020, identifying high-risk populations for targeted interventions.

Methods:
Data on death certificates were obtained from the 1999 to 2020 Centers for Disease Control and Prevention Wide-Ranging Online Study Epidemiologic Research (CDC-WONDER) database. We gathered data on demographics, place of death, and urban/rural classification. Mortality rates per 100,000 people were computed and classified according to state, year, sex, race/ethnicity, and urban/rural status. Trends were examined using Joinpoint regression.

Results:
A total of 12,573 deaths (age <35), 22,947 (35–64), and 21,782 (65+) were attributed to epilepsy. Mortality rates varied by age group, sex, race/ethnicity, and region. Trends showed significant increases, notably in middle-aged and older adults, with higher rates in males and nonHispani, African American populations.

Conclusion:
Epilepsy-related mortality exhibits demographic and regional disparities in the U.S. Understanding these patterns can guide targeted interventions to mitigate mortality risk.
О ХУДОЖЕСТВЕННО-ЭСТЕТИЧЕСКИХ ОСОБЕННОСТЯХ КНИГИ ИНАЛА ЧАТАО «ВСАДНИКИ»
Authors: С.Н. СИЮХОВ 
Published: December 2024

В статье анализируется произведение представителя адыгской диаспоры Инала Чатао «Всадники». Исследование выявляет художественные особенности романа в его сравнении с аналогичными произведениями адыгских писателей России. В работе отображается бережное отношение автора к феномену Адыгэ Хабзэ как к одному из главных составляющих этноса. Ставится вопрос о необходимости сравнительно типологического исследования литературы диаспоры в целом.
The article analyzes the work of the representative of the Adyghe diaspora Inal Chatao «Horsemen». The study reveals the artistic features of the novel in its comparison with similar works by Adyghe writers of Russia. The work shows the author's careful attitude to the phenomenon of Adyge Khabze as one of the main components of the ethnic group. The question is raised about the need for a comparative typological study of the literature of the Diaspora as a whole.
РЕШЕНИЕ СПЕЦИАЛЬНОГО ИНТЕГРО-ДИФФЕРЕНЦИАЛЬНОГО УРАВНЕНИЯ С СИНГУЛЯРНОСТЬЮ ПО ФАЗОВОЙ КООРДИНАТЕ
Authors: А.Л. ДЖАБРАИЛОВ 
Published: December 2024

В данной работе исследуются специальные интегро-дифференциальные уравнения с особенностью по фазовой переменной на предмет существования и единственности решения задачи Коши. Для доказательства существования и единственности решения задачи Коши для исходных специальных интегро-дифференциальных уравнений с особенностью по фазовой переменной используется замена, приводящая исходное уравнение к другому интегро-дифференциальному уравнению с неизвестной функцией, для которой и строится процесс Пикара, что позволяет доказать существование и единственность задачи Коши для полученного интегро-дифференциального уравнения. В свою очередь это позволяет доказать и существование и единственность исходной краевой задачи.
In this paper, special integro-differential equations with a singularity in the phase variable are investigated for the existence and uniqueness of a solution to the Cauchy problem. To prove the existence and uniqueness of a solution to the Cauchy problem for the original special integro-differential equations with a singularity in the phase variable, a substitution is used that reduces the original equation to another integro-differential equation with an unknown function, for which the Picard process is constructed, which makes it possible to prove the existence and uniqueness Cauchy problem for the resulting integrodifferential equation. In turn, this makes it possible to prove both the existence and uniqueness of the original boundary value problem.
ДЕЯТЕЛЬНОСТЬ СОВЕТСКИХ ПИСАТЕЛЕЙ В ФОРМИРОВАНИИ ПАТРИОТИЗМА В ГОДЫ ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ (НА ПРИМЕРЕ КАБАРДИНО-БАЛКАРИИ)
Authors: А.И. ТЕТУЕВ 
Published: December 2024

В статье освещена организаторская работа Союза писателей СССР по формированию и популяризации патриотических ценностей в обществе, рассмотрены вопросы, отражающие особенности партийного руководства над содержанием и качеством литературно-художественных журналов и произведений писателей, обобщен опыт творческой деятельности писателей Кабардино-Балкарии в формировании патриотизма в произведениях военных лет. Показана роль в формировании патриотизма опубликованных в передовых журналах и газетах произведений писателей-фронтовиков Алима Кешокова, Али Шогенцукова, Аскерби Шортанова, Кайсына Кулиева, Керима Отарова, Азрета Будаева и др., раскрыто влияние республиканской прессы на консолидацию населения в защите Отечества, в частности газеты «Социалистическая Кабардино-Балкария», в которой сочинения мастеров слова выходили на русском, кабардинском и балкарском языках. Сделан вывод о том, что главным направлением деятельности мастеров слова в годы Великой Отечественной войны явилась актуализация в их творчестве темы Родины, любви к ней.
The article highlights the organizational work of the USSR Writers' Union on the formation and popularization of patriotic values in society, examines issues reflecting the characteristics of the party leadership over the content and quality of literary and artistic magazines and works of writers, generalizes the experience of the creative activity of writers of Kabardino-Balkaria in the formation of patriotism in the works of the military years. The role in the formation of patriotism of the works of front-line writers Alim Keshokov, Ali Shogentsukov, Askerbi Shortanov, Kaisyn Kuliev, Kerim Otarov, Azret Budaev and others published in leading magazines and newspapers is shown; the influence of the republican press on the consolidation of the population in the defense of the Fatherland, in particular the newspaper, is revealed “Socialist Kabardino-Balkaria”, in which the works of masters of words were published in Russian, Kabardian and Balkar languages. It is concluded that the main direction of activity of wordsmiths during the Great Patriotic War was the actualization in their work of the theme of the Motherland and love for it.