bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sample size calculations for the differential expression analysis of RNA-seq data using a negative binomial regression model
Authors: Li Xiaohong , Wu Dongfeng , Cooper Nigel G.F. , Rai Shesh N. 
Published: January 2019

Abstract
High throughput RNA sequencing (RNA-seq) technology is increasingly used in disease-related biomarker studies. A negative binomial distribution has become the popular choice for modeling read counts of genes in RNA-seq data due to over-dispersed read counts. In this study, we propose two explicit sample size calculation methods for RNA-seq data using a negative binomial regression model. To derive these new sample size formulas, the common dispersion parameter and the size factor as an offset via a natural logarithm link function are incorporated. A two-sided Wald test statistic derived from the coefficient parameter is used for testing a single gene at a nominal significance level 0.05 and multiple genes at a false discovery rate 0.05. The variance for the Wald test is computed from the variance-covariance matrix with the parameters estimated from the maximum likelihood estimates under the unrestricted and constrained scenarios. The performance and a side-by-side comparison of our new formulas with three existing methods with a Wald test, a likelihood ratio test or an exact test are evaluated via simulation studies. Since other methods are much computationally extensive, we recommend our M1 method for quick and direct estimation of sample sizes in an experimental design. Finally, we illustrate sample sizes estimation using an existing breast cancer RNA-seq data.
Mulheres líderes em Educação. Da Baixada Fluminense para o mundo.
Authors: Malachias Rosangela 
Published: January 2019

O artigo descreve reflexivamente as etapas concluídas e bem sucedidas do Projeto de Pesquisa e Extensão iniciado em 2015 na Universidade do Estado do Rio de Janeiro, campus FEBF – Faculdade de Educação da Baixada Fluminense em Duque de Caxias, RJ, Brasil. A narrativa transita entre pessoalidade e impessoalidade compatíveis ao deslocamento identitário (HALL) da autora, que também é uma mulher negra, docente em uma universidade pública brasileira, protagonista e mediadora das ações construídas coletivamente com estudantes. A autodefinição e a autoavaliação (COLLINS) tem sido uma característica de pesquisas produzidas por e sobre mulheres negras.Palavras chave: Mulheres Negras – Líderes – Educação – Educomunicação - Diálogos. ABSTRACT The article describes the successful stages of the Research and Extension Project begun in 2015 at the Rio de Janeiro State University (UERJ), School of Education from Baixada Fluminense (FEBF) in Duque de Caxias, RJ, Brazil. The narrative transits between personal and not personal style that is compatible with the author's displacement (HALL), as a black woman, a teacher at a Brazilian public university, and a protagonist and mediator of the actions constructed collectively with students. Self-definition and self-evaluation (COLLINS) has been a feature of research produced by and about black women. Keywords: Black Women - Leaders - Education - Educommunication - Dialogues.
Estratégias de saúde realizadas por/para mulheres negras nas Américas: revisão de escopo
Authors: Prestes Clélia R. S. , L. Fachim Felipe , S. F. Paiva Vera 
Published: January 2019

Este artigo apresenta um panorama de estratégias de promoção da saúde de mulheres negras, voltadas à potencialização de resiliência, agência, emancipação, autonomia ou empoderamento. Os dados apresentados neste artigo correspondem a parte dos resultados coletados por uma revisão sistemática de escopo, que integrou a pesquisa “Estratégias de promoção da saúde de mulheres negras: interseccionalidade e bem viver”, com descrição de experiências reconhecidas no campo científico. Discutimos 11 estratégias estadunidenses e 1 brasileira, apresentando seus objetivos, perspectivas teóricas, descrições, quem as realizou, perfil de participantes, método, técnicas e instrumentos, além de discutir alguns resultados e o panorama geral, em diálogo com as perspectivas teóricas da abordagem multicultural dos direitos humanos na saúde e do feminismo negro. Ao final, apontamos recomendações para agendas futuras, no sentido da atenção à interseccionalidade como método de análise e de ação, produções teóricas de diversas regiões, epistemologias e cosmovisões, consideração das demandas específicas, responsabilidade ampla pela saúde das mulheres negras, valorização das experiências das mesmas, incluindo as não-acadêmicas, o feminismo negro como estratégia de enfrentamento das colonialidades de poder, diversidade na formação de equipes e fontes teóricas, ampliação das publicações de pesquisadoras(es) negras(os) e do movimento social negro e de mulheres negras, e ampliação das vozes de autoras(es) amefricanas(os).
BOUVET, Rachel; OLIVIERI-GODET, Rita, org. Geópoétique des confins. Rennes : Presses Universitaires de Rennes, 2018. 216p
Authors: Bernd Zilá 
Published: January 2019

Resenha do livro BOUVET, Rachel; OLIVIERI-GODET, Rita, org. Geópoétique des confins. Rennes : Presses Universitaires de Rennes, 2018. 216p
Targetable gene fusions identified in radioactive iodine refractory advanced thyroid carcinoma
Authors: van der Tuin K , Ventayol Garcia M , Corver W E , Khalifa M N , Ruano Neto D , Corssmit E P M , Hes F J , Links T P , Smit J W A , Plantinga T S , Kapiteijn E , van Wezel T , Morreau H 
Published: January 2019

ObjectiveGene alterations leading to activation of the MAPK pathway are of interest for targeted therapy in patients with advanced radioactive iodine refractory (RAI-R) thyroid carcinoma. Due to technical reasons gene fusion analysis in RNA isolated from formalin-fixed tumor tissues has till now been limited. The objective of the present study was to identify targetable gene rearrangements in RNA isolated from formalin-fixed RAI-R thyroid carcinomas.DesignRetrospective study in 132 patients with RAI-R thyroid carcinoma (59 papillary-, 24 follicular-, 35 Hürthle cell- and 14 anaplastic thyroid carcinoma).MethodsTotal nucleic acid (undivided DNA and RNA) was isolated from formalin-fixed tissue. Extensive gene fusion analysis was performed in all samples that tested negative for pathogenicBRAF,NRAS,HRASandKRASvariants.ResultsSeven targetable gene fusions were identified in the remaining 60 samples without known DNA variants. This includes frequently reported gene fusions such asCCDC6/RET(PTC1),PRKAR1A/RET(PTC2) andETV6/NTRK3, and gene fusions that are less common in thyroid cancer (TPM3/NTRK1,EML4/ALKandEML4/NTRK3). Of note, most gene fusions were detected in papillary thyroid carcinoma and MAPK-associated alterations in Hürthle cell carcinomas are rare (2/35).ConclusionTargetable gene fusions were found in 12% of RAI-R thyroid carcinoma without DNA variants and can be effectively identified in formalin-fixed tissue. These gene fusions might provide a preclinical rationale to include specific kinase inhibitors in the treatment regimen for these patients. The latter intends to restore iodine transport and/or take advantage of the direct effect on tumor cell vitality once progressive disease is seen.
Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis
Authors: Xu Guodong , You Dingyun , Wong Liping , Duan Donghui , Kong Fanqian , Zhang Xiaohong , Zhao Jinshun , Xing Wenhua , Han Liyuan , Li Li 
Published: January 2019

Objective
Previous studies have shown sex-specific differences in all-cause and CHD mortality in type 2 diabetes. We performed a systematic review and meta-analysis to provide a global picture of the estimated influence of type 2 diabetes on the risk of all-cause and CHD mortality in women vs men.

Methods
We systematically searched PubMed, EMBASE and Web of Science for studies published from their starting dates to Aug 7, 2018. The sex-specific hazard ratios (HRs) and their pooled ratio (women vs men) of all-cause and CHD mortality associated with type 2 diabetes were obtained through an inverse variance-weighted random-effects meta-analysis. Subgroup analyses were used to explore the potential sources of heterogeneity.

Results
The 35 analyzed prospective cohort studies included 2 314 292 individuals, among whom 254 038 all-cause deaths occurred. The pooled women vs men ratio of the HRs for all-cause and CHD mortality were 1.17 (95% CI: 1.12–1.23, I2 = 81.6%) and 1.97 (95% CI: 1.49–2.61, I2 = 86.4%), respectively. The pooled estimate of the HR for all-cause mortality was approximately 1.30 in articles in which the duration of follow-up was longer than 10 years and 1.10 in articles in which the duration of follow-up was less than 10 years. The pooled HRs for all-cause mortality in patients with type 2 diabetes was 2.33 (95% CI: 2.02–2.69) in women and 1.91 (95% CI: 1.72–2.12) in men, compared with their healthy counterparts.

Conclusions
The effect of diabetes on all-cause and CHD mortality is approximately 17 and 97% greater, respectively, for women than for men.
Post-tyrimas ugdymo moksluose: ontologinės ir epistemologinės įžvalgos
Authors: Garbauskaitė-Jakimovska Justina 
Published: January 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Šiuo straipsniu siekiama plėsti mokslinį diskursą post tyrimų metodologijos tema. Straipsnyje apžvelgiamos pagrindinės postmodernizmo, poststruktūralizmo ir posthumanizmo idėjos ir jų perkėlimas į mokslinius tyrimus ugdymo srityje, kintantis požiūris į duomenis, filosofijos svarbą, tyrimų atlikimo procedūras ir duomenų pristatymą. Pagrindinės idėjos iliustruojamos užsienio mokslininkų atliktų tyrimų pavyzdžiais.
Krūtinkaulio pseudoartrozės po resternotomijos gydymas Strasbūro krūtinės osteosintezės sistema: klinikinis atvejis
Authors: Janilionis Ričardas , Falcoz Pierre-Emmanuel , Jovaišas Vytautas , Jagelavičius Žymantas , Valančius Ramūnas 
Published: January 2019

Sternal pseudoarthrosis after resternotomy treated with the Strasbourg Thoracic Osteosyntheses System: a case report
Sternal dehiscence is a serious complication after general thoracic and cardiac surgery. Sternal resuturing, performed by simple rewiring or technical modification of rewiring, can fail overall when the bone quality is poor or the sternum is completely destroyed. A number of different sternal closure systems consisting of plates, screws, clips, and titanium bars have been recently introduced to treat the complicated sternal dehiscence. We describe the use of the Strasbourg Thoracic Osteosyntheses System (STRATOS) to treat complicated sternal dehiscence causing chest and back pain, sternum and chest instability, which was applied for the first time in Lithuania.Key words: sternotomy, sternal pseudoarthrosis, sternal osteosynthesis, chest instability, STRATOS.
Recidyvų vertinimas po hallux valgus korekcijos Lapidus operacijos ir Z-osteotomijos metodais
Authors: Janavičius Julius , Kocius Manvilius 
Published: January 2019

Tirti pacientai, dėl hallux valgus patologijos operuoti Respublikinėje Vilniaus universitetinėje ligoninėje 2006–2008 metais, atliekant Z-osteotomiją arba Lapidus operaciją: 70 pacientų (4 vyrai, 66 moterys), kuriems buvo operuota 80 pėdų (4 – vyrų, 76 – moterų) – po 40 atvejų abiejų operacijos tipų. Tirtų pacientų priešoperaciniai patologijos kriterijai buvo identiški ir sutapo svarbiausias indikacijų parametras – kampas tarp pirmo ir antro padikaulių (IMT1) buvo 16°–23°. Darbo tikslas – palyginti šių grupių recidyvų skaičių. Palyginus grupių pooperacinius rezultatus paaiškėjo, kad recidyvų skaičius vertinant tiek HV kampą, tiek IMT1 kampą po Z-osteotomijos yra mažesnis. Kadangi Z-osteotomija yra mažesnės apimties operacija ir techniškai paprastesnė, o pooperacinis laikotarpis trumpesnis, esant IMT1 kampui 16°–23°, ši operacija turėtų būti pasirenkama pirmiausiai. MTC1 sąnario artrodezė neapsaugo nuo hallux valgus deformacijos.Assessment of relapse after halux valgus Lapidus correction surgery and Z-osteotomy techniques
The aim of this study was to compare the number of relapses in two analogous groups after hallux valgus correction surgery by the Lapidus and Z-osteotomy techniques. The study included 70 patients (4 men, 66 women), who met the inclusion criteria. In total, 80 feet were analyzed (4 males and 76 female), i. e. two comparable groups of 40 feet. The postoperative results showed that the number of relapses as regards both the hallus valgus and the IMT1 angles was less after Z-osteotomy.
Žmogaus chorioninio gonadotropino reikšmė klinikinėje praktikoje
Authors: Tamašauskas Oldas , Šiaudinytė Ieva 
Published: January 2019

Žmogaus chorioninio gonadotropino (hCG) koncentracijos nustatymas dažniausiai naudojamas ankstyvo nėštumo diagnostikai, trukmei nustatyti bei nėštumui stebėti. Be to, HCG yra vertingas diagnozuojant savaiminį persileidimą, nesivystantį arektopinį nėštumą. Šis hormonas leidžia prenataliai įvertinti vaisiaus apsigimimų riziką. Taip pat hCG labai svarbus trofoblastinių ligų ir tam tikrų lokalizacijų vėžio diagnostikai, gydymo efektyvumo vertinimui. Retai, tačiau galimi ir klaidingai teigiamityrimų rezultatai dėl analitinių klaidų, tyrimams naudojamų įrenginių, prietaisų gedimų ar tam tikrų kraujyje esančių medžiagų (pvz.: heterofiliniai antikūnai, autoantikūnai, reumatoidinis faktorius, taip pat bilirubinas, hemoglobinas ar lipidai galilemti klaidingus, netikslius tyrimo rezultatus), todėl svarbu įvertinti ne vieno tyrimo rezultatus, o bendrą klinikinį vaizdą, visą surinktą informaciją ir apsvarstyti visas klinikinės diagnozės galimybes.Reikšminiai žodžiai: žmogaus chorioninis gonadotropinas, hCG, ektopinis nėštumas, klaidingai teigiamas rezultatas, Immulite2000, nėštumo diagnostika.The significance of human chorionic gonadotropin in clinical practice
pregnancy, assess its duration and observe its course. In addition, hCG is a valuable tool in the diagnostics of miscarriage, nondeveloping foetus or ectopic pregnancy. The measurements of this hormone allow to suspect the possible risk of foetalabnormalities. hCG is also used to diagnose and follow the course of particular types of cancer and diseases of throphoblastic origin. Rarely, though, it is possible that false positive results ensue due to failures of analysis, malfunction of laboratory equipment or particular substances circulating in the blood, i.e. heterophilic antibodies, autoantibodies, the rheumatoid factor, bilirubin, haemoglobin or lipids could possibly lead to false test results. Taking into consideration all the previously mentionedissues, it is always important to assess the whole clinical status of the patient, to gather all the possible information and to consider various diagnostic approaches and not to rely too heavily on one laboratory test.Key words: human chorionic gonadotropin, ectopic pregnancy, hCG, false-positive rezult, Immulite2000, pregnancy diagnostics
Onkologinių pacientų vaisingumo išsaugojimas: klinikinis atvejis
Authors: Amšiejienė Andrė , Usonienė Audronė , Šiaudinytė Ieva 
Published: January 2019

Onkologinių ligų nuolat daugėja, tačiau tobulėjančios gydymo galimybės labai didina išgyvenamumo rodiklius. Tai rodo vis didėjantį onkologinių pacientų gyvenimo kokybės po sėkmingo gydymo temos aktualumą. Prieš skiriant gonadotoksinį gydymą nuo vėžio, svarbu informuoti kiekvieną vaisingo amžiaus pacientę apie riziką pakenkti vaisingumui. Turėtų būti aptartas ir rekomenduotas vaisingumą išsaugantis gydymas. Kiaušidžių transpozicija, kiaušialąsčių ar embrionų kriokonservacija, kiaušidės audinio užšaldymas ir gonadotropinio hormono agonistų terapija – tai klinikiniais tyrimais pagrįsti vaisingumą išsaugantys gydymo metodai. Svarbu parinkti tinkamiausią ir priimtiniausią metodą, atsižvelgiant į moters amžių, kiaušidžių išteklius, socialinę ekonominę padėtį, religines pažiūras, sveikatos būklę ir gretutines ligas.Reikšminiai žodžiai: onkologiniai pacientai, gydymas nuo vėžio, vaisingumo išsaugojimas, kiaušidžių transpozicija, embrionų užšaldymas, kiaušialąsčių užšaldymas, kiaušidės audinio kriokonservacija ir transplantacija, gonadotropinių hormonų agonistaiFertility preservation in patients with cancer: case report
The total number of oncological diseases is constantly growing, but the improvement of treatment options significantly increases the survival rates. It shows the importance of the oncological patients’ quality of life after a succesful treatment. Prior to the prescription of any gonadotoxic medications, every patient of a fertile age should be informed about the risks of damaging fertility and recommended protective treatments. Ovarian transposition, oocyte, embryo or ovarian tissue cryoconservation and gonadotropin releasing hormone agonists’ (GnRHa) therapy these are the clinically tested fertility-protecting treatment methods. For the appropriate method to be selected, it is very important to take into consideration the female’s age, ovarian condition, social-economic situation, religious views, overall health condition, and related diseases.Key words: oncological patients, fertility protection, ovarian transposition, embryo cryoconservation, oocyte cryoconservation, ovarian tissue cryoconservation and transplantation, gonadotropin releasing hormone agonists
Chirurgai ir akademinės chirurgijos raida Kaune 1919–1940 metais
Authors: Zykas Vytautas 
Published: January 2019

Straipsnyje apžvelgiama chirurgijos raida nepriklausomoje Lietuvoje 1919–1940 metais. Pateikiami duomenys apie pirmuosius žingsnius organizuojant ir kuriant chirurgijos discipliną Aukštuosiuose kursuose ir vėlesnį jos vystymąsi universiteto Medicinos fakultete Kaune. Aprašoma iškiliausių to laikotarpio chirurgų J. Žemgulio, J. Dzirnės, H. Boito, A. Hagentorno, V. Kanaukos, V. Kuzmos, A. Maciūno, J. Čeponio, J. Jaržemsko ir kt. veikla kuriant praktinę ir akademinę chirurgiją Kaune ir Lietuvoje, aptariamas jų indėlis į mokslą, Lietuvos chirurgų draugijos organizavimą, pirmojo periodinio lietuviško žurnalo „Medicina“ steigimą. Pateikiami svarbesni faktai apie šių iškilių asmenybių visuomeninę veiklą, jų tragiškus likimus istorijos posūkiuose.

Surgeons and academic surgery in Kaunas between 1919–1940Prof. habil. dr. Vytautas Zykas
This article offers an historical overview of the development of surgery in Lithuania during the years of independence between 1919 and 1940. It describes the first steps of the creation of academic surgery and it‘s later development in the Universtity in Kaunas. The paper depicts facts about the prominent surgeons of that period – J. Žemgulys, J. Dzirnė, H. Boit, A. Hagentorn, V. Kanauka, A. Maciūnas, J. Čeponis, J. Jaržemskas and others who achieved major developments of practical and academic surgery, scientific works, organization of the Lithuanian Society of Surgeons and establishment of the first Lithuanian periodic medical journal „Medicina“. Some interesting facts about the public and social roles of those prominent personalities and the tragedy many of them lived at this turn of history are also presented.
POLA ASUH ANAK DALAM KELUARGA PEMULUNG
Authors: Ma'rifah Inayati , Nourwahida Cut Dhien , Adriansyah Andri Noor 
Published: January 2019

Abstract.The study of child care in the family scavenger in Jurang Mangu Timur South Tangerang. The goal is to find out how this kind of upbringing applied parents who work as scavengers. The research method using qualitative methods, and the type of research is descriptive. Researchers took the data by interviewing, observation and documentation. Informant was a parent who worked as scavengers and their children aged 4-12 years old. The results showed that parenting in a family scavenger leads to authoritarian upbringing. That pattern of care that have rigid rules in raising children. Each violation subject to physical punishment, verbal and psychological. Rarely praise or reward obtained when children obey this parents. Few or never existed to justify the praise children's behaviour. when they implement the rules. Low income levels have influenced parenting applied to the scavenger families. Income earned by only family scavenger Rp.400.000.00 until Rp600.000.00 every month, because of a low income, they even employ their children find stuff. They do not spoil the child, and also rare to spoil a child. Abstrak. Studi pengasuhan anak di pemulung keluarga di Jurang Mangu Timur Tangerang Selatan. Tujuannya adalah untuk mengetahui bagaimana cara pengasuhan yang diterapkan orangtua yang bekerja sebagai pemulung. Metode penelitian menggunakan metode kualitatif, dan jenis penelitiannya adalah deskriptif. Peneliti mengambil data dengan wawancara, observasi dan dokumentasi. Informan adalah orang tua yang bekerja sebagai pemulung dan anak-anak mereka yang berusia 4-12 tahun. Hasil penelitian menunjukkan bahwa mengasuh anak dalam pemulung keluarga mengarah pada pengasuhan yang otoriter. Itulah pola asuh yang memiliki aturan kaku dalam membesarkan anak. Setiap pelanggaran dikenakan hukuman fisik, verbal dan psikologis. Jarang pujian atau hadiah didapat saat anak-anak mematuhi orang tua ini. Beberapa atau tidak pernah ada untuk membenarkan perilaku pujian anak-anak. Ketika mereka menerapkan aturan. Tingkat pendapatan yang rendah telah memengaruhi pola asuh yang diterapkan pada keluarga pemulung. Penghasilan yang diperoleh hanya oleh pemulung keluarga Rp.400.000,00 hingga Rp600.000,00 setiap bulan, karena penghasilan yang rendah, mereka bahkan mempekerjakan anak-anak mereka mencari barang. Mereka tidak memanjakan anak, dan juga jarang memanjakan anak.
Program Sekolah dalam Upaya Pencegahan NAPZA
Authors: Fidrayani Fidrayani , Utami Desiana 
Published: January 2019

Abstract. Narcotics in unattended use can have a negative impact. The impact is potential to destroy the youth generation. It is necessary to hold the drug prevention programs, especially in schools as one of ways to prevent the widespread negative impact. The prevention can be through the role of parents, teachers and stakeholders as part of the community. The teachers’ role is divided into four sub-role, namely as educators, as advisors, as mentors, and particularly as problem solvers. The role of teachers certainly will not have power if it is not supported by the role of schools. Effots that are conducted by school stakeholder are as follow: a) compose the school rules; b) conduct inspections intensively and spontaneously; c) cooperate with related institutions for counseling and socialization; d) utilize extracurricular activities as means of prevention; e) integrate drug awareness into learning curriculum; (f) maximize the tasks as the effort of drug abuse prevention. Expectedly, these drug prevention efforts can be implemented by all schools as one of ways to prevent the destruction of the nation through NAPZA. Abstrak. Narkoba dalam penggunaan yang tidak diawasi dapat menimbulkan dampak negatif. Dampak tersebut tidak menutup kemungkinan dapat merusak generasi muda. Salah satu cara agar bahaya tersebut tidak meluas dampaknya, maka perlu program pencegahan terutama di sekolah. Pencegahan tersebut dapat melalui peran orang tua, guru dan pemangku kebijakan sebagai bagian dari masyarakat. Peran guru dibagi dalam empat yakni sebagai pendidik, penasehati, pembimbing dan lebih utama lagi sebagai problem solver. Peran guru ini tentu tidak akan memiliki kekuatan jika tidak didukung oleh peran sekolah. Upaya yang dilakukan oleh pihak sekolah adalah a) membuat tata tertib sekolah, b) melakukan razia intensif dan spontan, c) bekerjasama dengan instansi terkait guna penyuluhan dan sosialisasi, d) menggunakan ekstrakurikuler sebagai sarana pencegahan, e) memasukkan materi tentang narkotika ke dalam kurikulum pengajaran, f) memaksimalkan tugas dalam upaya pencegahan penyalahgunaan NAPZA. Diharapkan agar upaya pencegahan tersebut dapat diikuti oleh semua sekolah sebagai salah satu usaha untuk mencegah rusaknya anak bangsa melalui NAPZA.