bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolfenamic Acid Prevents Amyloid β-induced Olfactory Bulb Dysfunction In Vivo
Authors: Cornejo-Montes-de-Oca José M. , Hernández-Soto Rebeca , Isla Arturo G. , Morado-Urbina Carlos E. , Peña-Ortega Fernando 
Published: February 2018

Background:
Amyloid beta inhibits olfactory bulb function. The mechanisms involved in this
effect must include alterations in network excitability, inflammation and the activation of different
transduction pathways. Thus, here we tested whether tolfenamic acid, a drug that modulates several of
these pathological processes, could prevent amyloid beta-induced olfactory bulb dysfunction.

Objective:
To test whether tolfenamic acid prevents amyloid beta-induced alterations in olfactory bulb
network function, olfaction and GSK3β activity.

Method:
The protective effects of tolfenamic acid against amyloid beta-induced population activity inhibition
were tested in olfactory bulb slices from adult mice, while tolfenamic acid and amyloid beta
were bath-applied. We also tested the effects of amyloid-beta in slices obtained from animals pre-treated
chronically (21 days) with tolfenamic acid. The effects of amyloid beta micro-injected into the olfactory
bulbs were also tested, after two weeks, on olfactory bulb population activity and olfaction in control
and tolfenamic acid chronically treated animals. Olfaction was assessed with the odor-avoidance and the
habituation/cross-habituation tests. GSK3β activation was evaluated with Western-blot.

Results:
Acute bath application of tolfenamic acid does not prevent amyloid beta-induced inhibition of
olfactory bulb network activity in vitro. In contrast, chronic treatment with tolfenamic acid renders the
olfactory bulb resistant to amyloid beta-induced network activity inhibition in vitro and in vivo, which
correlates with the inhibition of GSK3β activation and the protection against amyloid beta-induced olfactory
dysfunction.

Conclusion:
Our data further support the use of tolfenamic acid to prevent amyloid beta-induced pathology
and the early symptoms of Alzheimer Disease.
Diastasis Recti Abdominis-diagnosis, Risk Factors, Effect on Musculoskeletal Function, Framework for Treatment and Implications for the Pelvic Floor
Authors: Werner Laura Anne , Dayan Marcy 
Published: February 2018

Background:Diastasis Recti Abdominis (DRA) can occur during pregnancy and postpartum. It is defined as an increase of the inter-recti distance (IRD) beyond normal values. The diagnosis of DRA is inconsistent within the literature and varies depending on measurement instrument and activity during measurement (rest versus active curl-up). DRA is characterized by the stretching of linea alba (LA) and contributes to a protrusion of the anterior abdominal wall due to increased laxity in the myofascial system that supports abdominal viscera. DRA has been postulated to affect lumbopelvic support and function due to laxity of the LA and altered angle of muscle insertion, but recent studies have not confirmed this. Risk factors for the development of DRA have been investigated in pregnancy to 12-months postpartum.Objective:Rehabilitation for DRA has been traditionally focused on reducing the IRD, but recent research has proposed that a sole focus on closing the DRA is suboptimal.Results:It is important alongside the rehabilitation of the abdominal wall that there is the consideration of the pelvic floor (PF). In healthy individuals, with the activation of the transversus abdominis, there is a sub-maximal co-contraction of the PF muscles. This co-contraction can be lost or altered in women with urinary incontinence. An increase in intra-abdominal pressure without simultaneous co-contraction of the PF may cause caudal displacement of the PF.Conclusion:The aim of this review is to bring the reader up to date on the evidence on DRA and to propose a rehabilitation framework for the whole abdominal wall in DRA with consideration of the impact on the PF.
In vitro Evaluation of the Marginal Fit and Internal Adaptation of Zirconia and Lithium Disilicate Single Crowns: Micro-CT Comparison Between Different Manufacturing Procedures
Authors: Riccitiello Francesco , Amato Massimo , Leone Renato , Spagnuolo Gianrico , Sorrentino Roberto 
Published: February 2018

Background:Prosthetic precision can be affected by several variables, such as restorative materials, manufacturing procedures, framework design, cementation techniques and aging. Marginal adaptation is critical for long-term longevity and clinical success of dental restorations. Marginal misfit may lead to cement exposure to oral fluids, resulting in microleakage and cement dissolution. As a consequence, marginal discrepancies enhance percolation of bacteria, food and oral debris, potentially causing secondary caries, endodontic inflammation and periodontal disease.Objective:The aim of the presentin vitrostudy was to evaluate the marginal and internal adaptation of zirconia and lithium disilicate single crowns, produced with different manufacturing procedures.Methods:Forty-five intact human maxillary premolars were prepared for single crowns by means of standardized preparations. All-ceramic crowns were fabricated with either CAD-CAM or heat-pressing procedures (CAD-CAM zirconia, CAD-CAM lithium disilicate, heat-pressed lithium disilicate) and cemented onto the teeth with a universal resin cement. Non-destructive micro-CT scanning was used to achieve the marginal and internal gaps in the coronal and sagittal planes; then, precision of fit measurements were calculated in a dedicated software and the results were statistically analyzed.Results:The heat-pressed lithium disilicate crowns were significantly less accurate at the prosthetic margins (p<0.05) while they performed better at the occlusal surface (p<0.05). No significant differences were noticed between CAD-CAM zirconia and lithium disilicate crowns (p>0.05); nevertheless CAD-CAM zirconia copings presented the best marginal fit among the experimental groups. As to the thickness of the cement layer, reduced amounts of luting agent were noticed at the finishing line, whereas a thicker layer was reported at the occlusal level.Conclusion:Within the limitations of the presentin vitroinvestigation, the following conclusions can be drawn: the recorded marginal gaps were within the clinical acceptability irrespective of both the restorative material and the manufacturing procedures; the CAD-CAM processing techniques for both zirconia and lithium disilicate produced more consistent marginal gaps than the heat-pressing procedures; the tested universal resin cement can be safely used with both restorative materials.
Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis
Authors: Tangren Jessica Sheehan , Powe Camille E. , Ecker Jeffrey , Bramham Kate , Ankers Elizabeth , Karumanchi S. Ananth , Thadhani Ravi 
Published: February 2018

Background and objectives
Kidney stones are associated with future development of hypertension, diabetes, and the metabolic syndrome. Our objective was to assess whether stone formation before pregnancy was associated with metabolic and hypertensive complications in pregnancy. We hypothesized that stone formation is a marker of metabolic disease and would be associated with higher risk for maternal complications in pregnancy.

Design, setting, participants, & measurements
We conducted a retrospective cohort study of women who delivered infants at the Massachusetts General Hospital from 2006 to 2015. Women with abdominal imaging (computed tomography or ultrasound) before pregnancy were included in the analysis. Pregnancy outcomes in women with documented kidney stones on imaging (stone formers, n=166) were compared with those of women without stones on imaging (controls, n=1264). Women with preexisting CKD, hypertension, and diabetes were excluded.

Results
Gestational diabetes and preeclampsia were more common in stone formers than nonstone formers (18% versus 6%, respectively; P<0.001 and 16% versus 8%, respectively; P=0.002). After multivariable adjustment, previous nephrolithiasis was associated with higher risks of gestational diabetes (adjusted odds ratio, 3.1; 95% confidence interval, 1.8 to 5.3) and preeclampsia (adjusted odds ratio, 2.2; 95% confidence interval, 1.3 to 3.6). Infants of stone formers were born earlier (38.7±2.0 versus 39.2±1.7 weeks, respectively; P=0.01); however, rates of small for gestational age offspring and neonatal intensive care admission were similar between groups (8% versus 7%, respectively; P=0.33 and 10% versus 6%, respectively; P=0.08). First trimester body mass index significantly influenced the association between stone disease and hypertensive complications of pregnancy: in a multivariable linear regression model, stone formation acted as an effect modifier of the relationship between maximum systolic BP in the third trimester and body mass index (P interaction <0.001).

Conclusions
In women without preexisting diabetes, hypertension, and CKD, a history of nephrolithiasis was associated with gestational diabetes and hypertensive disorders of pregnancy, especially in women with high first trimester body mass index.
Comparison of Three Rotor Designs for Rubber Mixing Using Computational Fluid Dynamics
Authors: Das Suma R. , Dhakal Pashupati , Chandy Abhilash J. 
Published: February 2018

ABSTRACT
In recent years, there has been an increasing demand for efficient mixers with high-quality mixing capabilities in the rubber product industry, with the focus of producing fuel-efficient tires. Depending on the functional characteristics of the tire and thus the compounding ingredients, different types of mixers can be used for the rubber mixing process. Hence, the choice of an appropriate mixer is critical in achieving the proper distribution and dispersion of fillers in rubber and a consistent product quality, as well as the attainment of high productivity. With the availability of high-performance computing resources and high-fidelity computational fluid dynamics tools over the last two decades, understanding the flow phenomena associated with complex rotor geometries such as the two- and four-wing rotors has become feasible. The objective of this article is to compare and investigate the flow and mixing dynamics of rubber compounds in partially filled mixing chambers stirred with three types of rotors: the two-wing, four-wing A, and four-wing B rotors. As part of this effort, all the 3D simulations are carried out with a 75% fill factor and a rotor speed of 20 rpm using a computational fluid dynamics (CFD) code. Mass flow patterns, velocity vectors, particle trajectories, and other mixing statistics, such as cluster distribution index and length of stretch, are presented here. All the results showed consistently that the four-wing A rotor was superior in terms of dispersive and distributive mixing characteristics compared with the other rotors. The results also helped to understand the mixing process and material movement, thereby generating information that could potentially improve productivity and efficiency in the tire manufacturing process.
Lukisan Sebagai Materi Animasi dalam Film “Aku, Trimah Perempuan Itu”
Authors: Arum Retnowati Dyah 
Published: February 2018

A film is one of the media that is able to deliver an event andmessage as well, not only ideologically but also structurally throughdiscontinuity principle. Film as a medium to reflect an event with manystyles according to its characteristics. This film is created to bring up aphenomenon that happened in society, using animation technique stressed to frame by frame recording technique, panning and zooming system that are combined with live action technique.It is such a concern when we watch, read and hear from the mediathat contain of news about murders of his/her own family members. Amother who killed her own child, a wife who mutilated her own husband.“Me, Trimah That Woman”is an illustration about a woman who experienced and did a murder on her own way, killed her children and herhusband. What kind of thoughts and how could this happen, that made awoman, a mother, a wife is able to do this kind of thing?The story that packaged in this film tries to revive a group of pictures to represent dream and imagination world of the actor in surrealism style, and used as an effort to deliver the message non verbally through meaningful symbols. The symbol is also used to replace the violence scenes and the effects on film as well. Those entirely aimed in order to make this film to become a reflection, to grow the empathy, sympathy and also wisely understanding to judge an incident in this life.
Mencitrakan Sang Kandidat: Si “Tukang Foto” Iklan Politik
Authors: Bukit Dewi Sartika 
Published: February 2018

Abstrak Perkembangan fotografi komersial di Indonesia akhir-akhir ini telah memasuki ranah politik, terutama sejak diberlakukannya sistem demokrasi langsung. Masyarakat menentukan pilihan mereka melalui pendekatan para kandidat dan calon, baik berupa kampanye maupun melalui iklan-iklan politik yang hadir di media massa, maupun berupa cetak billboard dan selebaran. Dalam iklan-iklan politik, terutama ikan luar ruang, kandidat yang dianalogikan sebagai produk, dipotret dan dikemas dalam sebuah desain iklan yang membawa pesan-pesan penting berupa pencitaan dan direduksi dalam sebuah gambar. Dengan demikian, fungsi fotografer iklan baik secara teknis maupun ide memberi pengaruh yang besar terhadap pencitraan kandidat, yang secara tidak langsung berpengaruh terhadap jalannya negara selanjutnya setelah kandidat tersebut melaju ke urusan birokrasi negara. Di samping itu, permasalahan ekonomi yang berbanding lurus dengan pencitraan kandidat dalam iklan-iklan politik, ternyata menyimpan kemelut yang kompleks. AbstractImaging the Candidate : the “Photographer” of Politic Ads. Lately, the development of commercial photography in Indonesia has entered the realm of politics, especially since the system of direct democracy has been enacted. Communities determine their choice through the candidates and prospective nominees, either through campaigns or political advertisements presented in mass media, as well as on billboards and flyers printed form. In political ads, especially the outdoor ads, the candidate analogized as product, were photographed and packaged in advertisement design carrying important messages in the form of imagery and reduced in an image. Thus, the function of advertising photographers, both technically and in ideas, giving major influences on imaging the candidate, which indirectly affect the course of the country once the candidate proceeds to the affairs of the state bureaucracy. In addition, the economic problems which unfortunately are in direct proportion to the imaging candidate in the politics ads, turn out keeping a complex crisis.
PENCIPTAAN FOTOGRAFI SUREALISME HUMAN AND TIME
Authors: Amala Marventyo 
Published: February 2018

AbstrakWaktu adalah sebuah konsep yang sepenuhnya tergantung pada persepsi manusia. Waktuadalah sebuah konsep yang tergantung pada kejadian-kejadian yang dapat diperbandingkandengan apa yang dialami. Seseorang, bahkan setiap manusia tidak bisa terlepas dari entitaswaktu ini. Sekuat apa pun ingin melepaskan diri, manusia tidak akan pernah lepas dari“sang” waktu, bahkan saat mati pun masih dilingkupi oleh waktu. Berlandaskan pada konseptentang waktu, maka terbesit sebuah ide mengenai penciptaan fotografi dengan tema waktuyang bergaya surealis. Karakteristik karya fotografi ini lebih menekankan pemotretan subjekmanusia dibalut dengan kain putih sebagai representasi waktu. Unsur pencahayaan menjadihal yang sangat diperhatikan agar ekpresi dari subjek dapat terekam dengan baik. Sementaraitu, sifat momen, pilihan arah cahaya, dan eksplorasi dengan menggunakan teknik multipleexposure, menjadi bagian yang juga ditekankan pada karya ini. AbstractThe Creation of Surrealism Photography: Human and Time. Time is a concept that isentirely dependent on human perception. Time is a concept that depends on events that canbe compared with what happened. Someone, even every man cannot be separated from theentity of time. No matter how someone wants to get away, he would never be separated from“his” time, even death is still surrounded by time. Based on the concept of time, then an ideaabout the creation of photography with the theme of time and surrealist styles popped up. Thecharacteristis of this photography project emphasizes on shooting human subjects wrappedin a white cloth as a representation of time. Lighting element is very highly considered toshow the expressions of the subject that it could be recorded properly. In the meanwhile, themoment, the choice of light direction, and exploration using multiple exposure technique, areessential parts of this work.
”Ruteng is da City”: Representasi Lokalitas dalam Musik Rap Manggarai
Authors: Yuliantarii Ans. Prawati 
Published: February 2018

Penelitian ini membahas fenomena musik rap di Manggarai dan representasi lokalitas yang ada di dalam lagu-lagunya. Untuk melihat hal itu dipergunakan teks lagu sebagai obyek kajiannya. Lagu “Ruteng is da City” karangan Lipooz dipilih sebagai bahan kajian untuk melihat elemen-elemen lokal di dalam teksnya itu direpresentasikan dalam lagu sebagai pembentuk identitas rap Manggarai. Untuk membahas elemen lokalitasnya dipergunakan konsep cultural-melding-and-mediation oleh Lull. Sementara untuk mempertajam analisis representasi lokalitas dipergunakan teori Collective Representation dari Durkheim. Berdasarkan penelitian dapat disimpulkan bahwa melalui teks lagu “Ruteng is de City” dapat dilihat pengalaman kolektif masyarakat, kebiasaan khas, kode yang merupakan simbol kota Ruteng, dan barang yang menjadi produk lokal wilayah itu. Elemen-elemen lokal itu merepresentasikan budaya Manggarai yang berisi kepercayaan, norma-norma, nilai dan pandangan filosofis masyarakat yang membentuk identitas masyarakat Manggarai. “Ruteng is da City”: Representation of Locality in Manggarai Rap Music. This research discusses the phenomenon of rap in Manggarai and the representation of locality of the songs. To figure out this phenomenon, the textual examination on the song lyrics of “Ruteng is da City” composed by Lipooz is particularly selected as the object of study to identify the local elements of the text (lyric) which are represented in the song as the form of the identity of Manggarai rap. The identification of local elements is based on cultural-melding-and-mediation concept proposed by Lull. Meanwhile, in analyzing the representation of locality in the text, Durkheim’s theory of Collective Representation is adopted. According to the research result, it is concluded that the song text of “Ruteng is d City” contains the collective experience of the community, norms, the symbolic code of the town (Ruteng), and the local commodities of the town. The local elements found in the song represent Manggarai traditional culture that includes beliefs, norms, values and philosophical views of Manggarai society which essentially form the identity of Manggarai people.
Apropriasi Musikal dan Estetika Musik Gamat
Authors: Martarosa Martarosa 
Published: February 2018

Penelitian ini membahas cara orang Pesisir Minangkabau mengimbuhkan atau mencangkokkan beberapa genre musik tradisional Pesisir Minangkabau hingga genre musik ini menjadi semakin kuat diakui sebagai musik mereka. Penelitian difokuskan pada perubahan dan estetika. Secara musikologis data dipisahkan menjadi dua aspek yaitu aspek musikal dan aspek sosial atau tekstual dan kontekstual. Secara tekstual data dianalisis berdasarkan konsep estetika yang meliputi harmoni dan orkestrasi yang menyangkut penyajian formasi instrumen. Konsep ini dapat digunakan untuk melihat bentuk-bentuk apropriasi musikal yang terjadi pada musik gamat sebagai kajian analisis dalam bentuk dan struktur, vibrato dan ornamentasi melalui teknik penyajian garitiak dan gayo. Berdasarkan penelitian dapat disimpulkan bahwa proses interaksi dan cara kepemilikan atau apropriasi terhadap musik gamat oleh orang-orang Minangkabau diduga terjadi melalui penawaran-penawaran pada sisi musikal antar budaya timbal balik.
The Psoriasis Patient Journey: Progression from Topical to Biologic Treatment for Psoriasis Patients in the United States
Authors: Wu Jashin J , Lu Minyi , Veverka Karen A , Smulders Maartje , Papademetriou Eros , Junhua Yunjua , Feldman Steven R 
Published: February 2018

Abstract not available. Disclosures: Study sponssored by LEO Pharma. Copyright 2018 SKIN
Secukinumab Achievement of Psoriatic Arthritis Disease Activity Score (PASDAS)-Related Remission: 2-Year Results from a Phase 3 Study
Authors: Coates LC , Gladman DD , Nash P , FitzGerald O , Kavanaugh A , Rasouliyan L , Pricop L , Ding K , Gaillez C 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN
Sustained and Improved Efficacy of Tildrakizumab from Week 28 to Week 52 in Treating Moderate-to-Severe Plaque Psoriasis
Authors: Elewski Boni , Menter Alan , Crowley Jeffrey , Tyring Stephen , Zhao Yang , Lowry Simon , Rozzo Stephen , Mendelsohn Alan , Parno Jeffrey , Gordon Kenneth 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by SUN PHARMA. Copyright SKIN 2018
Treatment with Fixed Combination Calcipotriol 50 ug/g and Betamethasone Dipropionate 0.5 mg/g Foam Provides Rapid and Significant Itch Relief in Patients with Psoriasis
Authors: Stein Gold Linda , Yamauchi Paul , Pariser David , Xu Zhenyi , Osterdal Marie L , Bagel Jerry 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by LEO Pharma. Copyright 2018 SKIN
US Patient Satisfaction with Secukinumab Treatment Among Patients with Both Psoriatic Arthritis and Psoriasis: Data from a Web-Based Survey
Authors: Magrey Marina , Wolin Daniel , Mordin Margaret , McLeod Lori , Davenport Eric , Hur Peter 
Published: February 2018

Abstract not available. Disclosures: Study supported by Novartis. Copyright 2018 SKIN
Pharmacokinetic Evaluation of Once-Daily Topical 4% Minocycline Foam in Adult and Pediatric Subjects with Moderate-to-Severe Acne in Two Phase 1 Studies
Authors: Jones Terry M , Ellman Herman , DeVries Tina 
Published: February 2018

Abstract not available. Disclosures: Study s supported by Foamix Pharmaceuticals, Inc. Copyright SKIN 2018
Efficacy of an Ointment Body Spray to Improve the Appearance of Dry, Ashy Skin and Alleviate Moderate to Severe Dryness on the Heel
Authors: Weber TM , Arrowitz CE , Jiang LI , Qian K , Filbry A 
Published: February 2018

Abstract not available. Disclosures: Study supported by Beiersdorf, Inc.
Clinical Efficacy or Tildrakizumab in Patients with Chronic Plaque Psoriasis Over 2 Years of Treatment: Results from Long-Term Extensions to 2 Phase 3 Clinical Studies
Authors: Papp Kim , Reich Kristian , Blauvelt Andrew , Thaci Diamant , Sinclair Rodney , Tyring Stephen K , Cichanowitz Nicole , Green Stuart , Li Qing , La Rosa Carmen 
Published: February 2018

Abstract not available. Study supported by Merck & Co., Inc.
Patient-Reported Outcomes from Two Randomized, Double-Blind, Vehicle Controlled Phase 3 Trials in Axillary Hyperhidrosis (ATMOS-1 & ATMOS-2)
Authors: Pariser David M , Hebert Adelaide A , Drew Janice , Quiring John , Glaser Dee Anna 
Published: February 2018

Abstract not available. Disclosures: Study supported by Dermira. Copyright SKIN 2018
Cemiplimab (REGN2810), a Fully Human Anti-PD-1 Monoclonal Antibody, for Patients with Unresectable Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma: Initial Safety and Efficacy from Expansion Cohorts of Phase 1 Study
Authors: Papadopoulos Kyriakos P , Owonikoko Taofeek K , Johnson Melissa L , Brana Irene , Gil-Martin Marta , Perez Raymond P , Moreno Victor , Salama April K , Calvo Emiliano , Yee Nelson S , Safran Howard , Gonzalez-Martin Antonio , Aljumaily Raid , Mahadevan Daruka , Mohan Kosalai K , Li Jingjin , Stankevich Elizabeth , Lowy Israel , Fury Matthew G , Homsi Jade 
Published: February 2018

Abstract not available. Disclosures: Study sponsored by Regeneron Pharmaceuticals Inc. and Sanofi. Copyright 2018 SKIN