bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of miR-155 as a biomarker for the diagnosis and prognosis of lung cancer: a systematic review with meta-analysis
Authors: Shao Chuchu , Yang Fengming , Qin Zhiqiang , Jing Xinming , Shu Yongqian , Shen Hua 
Published: May 2019

Abstract
Abstract
Background: In recent years, several studies have investigated the impact of miR-155 on the diagnosis and prognosis of LCa, but results of these researches were still controversial due to insufficient sample size. Thus, we carried out this systematic review and meta-analysis to figure out whether miR-155 could be a screening tool in the detection and prognosis of LCa.
Methods: A meta-analysis of 13 articles with 19 studies was performed by retrieving the PubMed, Embase and other bibliographic databases. We screened all correlated literaters until December 1st, 2018. For the diagnostic value of miR-155 in LCa, SEN, SPE, PLR, NLR, DOR and AUC were pooled to evaluate the accuracy of miRNA-155 in the diagnosis of LCa. Subgroup and meta-regression analyses were performed to distinguish the potential sources of heterogeneity between studies. For the prognositic value of miR-155 in LCa, the pooled HRs and 95% CIs of miRNA-155 for OS and DFS/ PFS were calculated.
Results: For the diagnosis analysis of miR-155 in LCa, the pooled SEN and SPE were 0.82 (95% CI: 0.72-0.88) and 0.78 (95% CI: 0.71-0.84), respectively. Besides, the pooled PLR was 3.75 (95% CI: 2.76-5.10), NLR was 0.23 (95% CI: 0.15-0.37), DOR was 15.99 (95% CI: 8.11-31.52) and AUC was 0.87 (95% CI: 0.84-0.90), indicating a significant value of miR-155 in the LCa detection. For the prognostic analysis of miR-155 in LCa, up-regulated miRNA-155 expression was not significantly associated with a poor OS (pooled HR = 1.26, 95% CI: 0.66-2.40) or DFS/PFS (pooled HR = 1.28, 95% CI: 0.82-1.97).
Conclusions: This meta-analysis demonstrated that miR-155 could be used as a potential biomarker in the diagnosis of LCa but not an effective biomarker for predicting the prognosis of LCa. Furthermore, more well-designed researches with larger cohorts were warranted to confirm the value of miR-155 for the diagnosis and prognosis of LCa.
Keywords: lung cancer, miR-155, diagnosis, prognosis, biomarker
A review of sustainable septage management strategies on the islands in Croatia
Authors: Margeta Jure 
Published: May 2019

Abstract
This paper analyzes the problem of septage management on Croatian islands in accordance with the circular economy framework. The systems approach methodology has been used to analyze management issues. A large number of individual housing facilities on Croatian islands are not connected to the public sewage system. As a solution to the requirements of the competent services, holding tanks are used which are largely permeable. Due to tourism activities the amount of wastewater seasonally varies considerably and in summer is up to 10 times higher than in winter. Such a situation creates major problems for property owners due to mostly uncontrolled disposing of septage, which endangers the environment and human health. Although the situation is improving by application of EU directives, due to poor population density septage management will remain a permanent problem. The EU legal framework requires that organic waste be disposed of in accordance with the principles of a circular economy. This also applies to septage. It has been found that simple and robust options are sustainable and the best choice for a small island environment. After appropriate treatment, septage becomes a resource that strengthens the viability of living on the islands.
Clinical Utility of the Ankle-Brachial Index and Toe Brachial Index in Patients with Diabetic Foot Ulcers
Authors: Ababneh Mutasem , Al Ayed Mousab Y. , Robert Asirvatham A. , Al Dawish Mohamed A. 
Published: May 2019

Background:
This cross sectional study investigated the clinical use of the ankle-brachial
index (ABI) and toe brachial index (TBI) in 91 type 2 diabetic foot ulcer patients who visited the diabetic
foot clinic, Prince Sultan Military Medical City, Saudi Arabia during July 2017 and January 2018.

Materials and Methods:
The ABI and TBI facilitated the detection of peripheral arterial disease (PAD)
and the patients’ medical records were used to collect the clinical and demographic variables. The variables
of duration (p = 0.047) and treatment (p = 0.046) of the ABI showed significant differences. Age (p
= 0.034) and duration (p = 0.001) were the factors related to the diagnosis of TBI by the “χ2” test.

Results:
From the TBI, 26.4% of the patients were found to have PAD, while the ABI showed that
21.8% of patients had the condition. However, no statistical significance was noted. From the regression
analysis, the variable duration of diabetes (≥ 20 years of age) was recognized as an independent
risk factor for TBI.

Conclusion:
In conclusion, it is recommended both the ABI and TBI to be used as screening tests for
PAD in diabetic foot ulcer patients.
Risk Factors for Ischemic Heart Disease
Authors: Bisciglia Andrea , Pasceri Vincenzo , Irini Diego , Varveri Antonio , Speciale Giulio 
Published: May 2019

Background:
Several risk factors have been empirically linked to an increased risk of cardiovascular
disease. Some of them are therapeutically amenable to modification; while others are not.
Modifiable risk factors include physical inactivity, tobacco use, diet, “bad fats” in the blood, hypertension,
and being overweight; while non-modifiable risk factors include the patient’s family history,
the presence versus absence of diabetes mellitus, and demographic characteristics like age, gender,
ethnicity, and socio-economic status.

Methods:
In this article, we review those risk factors that are both clinically important and amenable
to change.

Conclusion:
To prevent cardiovascular disease, it is important to minimize modifiable risk factors,
like LDL cholesterol.
Analytical Modeling on Vibration Analysis of Cracked Functionally Graded Plate Submerged in Fluid
Authors: Soni Shashank , Jain Nitin K. , Joshi Prasad V. 
Published: May 2019

Background:It is established that the vibration response of submerged structures is quite different than that calculated in vacuum. Therefore, the study of vibration characteristics of submerged plate structures is important for safety and its designing purpose.Objective:To investigate the fundamental frequency of partially cracked Functionally Graded (FG) submerged plate based on analytical approach.Methods:The governing differential equation of the cracked-submerged plate is derived based on Kirchhoff’s thin classical plate theory in conjunction with the potential flow theory. The line spring model is used to incorporate the effect of crack in the form of additional bending whereas the effect of fluid medium is incorporated in form fluids forces associated with inertial effects of its surrounding fluids. The Bernoulli’s equation and velocity potential function are used to define the fluid forces acting on plate surface.Results:An approximate solution for governing equation of coupled fluid-plate system is obtained by using the Galerkin’s method. For validation of the present results, they are compared with the existing results of the previous published work, which are in good agreements. New results for natural frequencies as affected by gradient index, crack length, level of submergence and immersed depth of plate are presented for Simply Supported (SSSS) boundary condition.Conclusion:It has been concluded that the presence of crack and fluidic medium significantly affect the natural frequencies of the plate. It is observed that the increase in the length of crack and level of submergence decreases the fundamental frequency. In this paper, few patents have been discussed.
CONTEXTO DE DESENVOLVIMENTO E A PERCEPÇÃO ESPACIAL DE CRIANÇAS
Authors: Krebs Ruy Jornada , Carniel Joana Desirée , Machado Zênite 
Published: May 2019

Mudanças na estrutura social dos contextos onde a criança participa podem influenciar o desenvolvimento da percepção espacial. O objetivo deste estudo foi investigar os contextos de desenvolvimento e a percepção espacial de crianças, fundamentado na Teoria Bioecológica de Bronfenbrenner. O questionário de Machado (2008) foi utilizado com 60 crianças. Os resultados mostraram que a preferência pelo local de lazer está relacionada com a estrutura física, segurança, falta de autonomia das crianças, transporte e lugares frequentados pelos pais. Verificou-se que a percepção espacial das crianças está relacionada aos locais frequentados por elas como, a casa, a escola e o próprio bairro.
AULA DE EDUCAÇÃO FÍSICA NÃO É LUGAR DE ESTUDAR O CORPO!?
Authors: Isse Silvane Fensterseifer 
Published: May 2019

Este texto discute a compreensão de estudantes de Ensino Médio acerca das relações entre estudar o corpo e a educação física escolar. O estudo utilizou observações, entrevistas semi-estruturadas, diálogos e diário de campo como instrumentos para coleta de informações. Os resultados apontam que há uma dissociação entre educação física na escola e os estudos sobre o corpo. Estudar o corpo é relacionado às disciplinas de biologia e ciências e a intervenções de profissionais da saúde na escola. Há uma perspectiva biomédica, individualista e hierárquica em relação aos saberes do corpo, que é compreendido a partir de uma perspectiva anistórica, descontextualizada, disciplinar e fragmentada. Problematiza a ideia de que estudar o corpo está diretamente relacionado a aprender cuidados que o tornam saudável, relacionado muito mais às ciências da saúde do que à pedagogia.
Optimization of Genetic Algorithm for Implementation Designing and Modeling in Academic Scheduling
Authors: Suratno Tri , Rarasati Niken , Z` Gusmanely 
Published: May 2019

This research was investigated using the Genetic Algebra Method for scheduling lectures and practicums. Genetic algorithms are used to solve problems that are modeled according to evolutionary principles in biological sciences. The application of the Genetic Algebraic Method for Scheduling Lectures and Practices is expected to be further developed into a computerized system that can replace the manual lecture scheduling and practicum methods so that it can produce a more accurate schedule with existing rules in a shorter time. The results of the use of the genetic algorithm method are obtained from the results of the data which are fixed scheduling lecture data and can be recommended for lectures according to the lecture schedule obtained from the results of generating genetic algorithms.
Evaluation of phenylephrine and exercise with or without trocarization for treatment of suspected nephrosplenic entrapment in horses
Authors: Gillen Alex M. , Munsterman Amelia S. , Reid Hanson R. 
Published: May 2019

Abstract
OBJECTIVE To report the outcomes of horses with suspected nephrosplenic entrapment (NSE) of the large colon treated by IV phenylephrine administration and exercise with and without trocarization (ie, medical management).
DESIGN Retrospective, observational study.
ANIMALS 134 horses.
PROCEDURES Electronic medical records were searched to identify horses that underwent medical management for suspected NSE at a veterinary teaching hospital between 1995 and 2014. Demographic information, physical and ultrasonographic examination findings, treatment information (including the number of times the treatment was performed and patient response), surgical findings if applicable, complications, and patient outcome were recorded. Descriptive statistics were reported.
RESULTS 72 horses had suspected NSE that resolved with medical treatment; 59 of 62 horses underwent laparotomy when medical management failed, and 3 were euthanized without surgery. Twenty-five of the 59 horses had confirmed NSE that was surgically corrected, and 34 had lesions other than or in addition to NSE. All horses that had surgically corrected NSE and 18 of 34 horses that had other lesions survived to hospital discharge. The odds of resolution of NSE with medical management were greater for horses that underwent ≤ 2 (vs > 2) treatments. The treatment success rate for horses that underwent trocarization was not greater than that for horses that did not have the procedure.
CONCLUSIONS AND CLINICAL RELEVANCE Suspected NSE resolved with the described medical management for most horses. However, results indicated the potential for misdiagnosis was high. Timely surgical intervention is recommended for horses that fail to respond to medical treatment.
PELANGGARAN KODE ETIK DAN PEDOMAN PERILAKU HAKIM
Authors: Imran Imran 
Published: May 2019

ABSTRAKDalam sistem peradilan pidana penanganan suatu kasus dimulai sejak kasus itu muncul, kemudian ditangani oleh polisi, hingga proses akhir dari penegakan hukum terletak pada putusan hakim. Putusan hakim dapat berupa menjatuhkan hukuman ataupun membebaskan seorang terdakwa. Dalam putusan hakim akan terlihat kemampuan hakim dalam mengonstruksi kasus sejak dakwaan dibacakan hingga pledoi diucapkan. Semua konstruksi hakim tersebut akan tergambar dalam pertimbangan-pertimbangan. Dalam pertimbangan tersebut akan terlihat apakah suatu putusan tersebut melanggar kode etik atau tidak. Apa yang terlihat dalam dua putusan hakim yang dikeluarkan oleh Pengadilan Negeri Tobelo, mencerminkan adanya persoalan ketika seorang terdakwa dua kali dihukum oleh majelis hakim yang sama untuk perbuatan yang sama pula. Hal inilah yang kemudian menjadi rumusan masalah, apakah putusan tersebut melanggar Kode Etik dan Pedoman Perilaku Hakim atau tidak? Dengan menggunakan metode penelitian hukum normatif yang memfokuskan kajian pada data sekunder, maka akan terlihat bagaimana sesungguhnya dua putusan tersebut. Hasil dari penelitian ini menunjukkan telah terjadi pelanggaran Kode Etik dan Pedoman Perilaku Hakim yang dilakukan oleh majelis hakim.Kata kunci: kode etik dan pedoman perilaku hakim; sistem peradilan pidana; profesionalisme. ABSTRACT In the criminal justice system, the handling of a case starts since the claim arises, then is handled by the police, until the final process of law enforcement, which lies in the judge's decision. Judges' decisions can be in the form of sentencing or acquitting a defendant. The ability of a judge to construct a case will appear in the decision from the time the indictment is read until the plea is pronounced. In these considerations, it will be seen whether the judge's decision violates the code of ethics or not. Two judges' decisions issued by the Tobelo District Court reflect the problem in which a defendant was twice sentenced by the same panel of judges for violating the same law. This is what then becomes the formula of the problem, whether the decision violates the Code of Ethics and Code of Conduct of Judges or not. By using normative legal research method focusing on secondary data construing, it will expose the fact of these two decisions. The results of this analysis indicate that there are violations of the Code of Ethics and Code of Conduct of Judges been committed by the panel of judges examining the case. Keywords: code of ethics and code of conduct of judges; criminal justice system; professionalism.
KEARIFAN KAENBAUN SEBAGAI DASAR KONSEPTUAL PADA TATA SPASIAL ARSITEKTUR PERMUKIMAN SUKU DAWAN DI DESA KAENBAUN (The Kaenbaun Wisdom as a Conceptual Basis of the Spatial Design of Settlement Architecture of Dawanese in Kaenbaun Village)
Authors: Purbadi, MT Ir. Yohanes Djarot , Djunaedi Achmad , Sudaryono Sudaryono 
Published: May 2019

The Research based on an intercultural contact approach is significant to study the traditional settlements and to support the preservation of local culture-based architecture in Indonesia. The Kaenbaun village inhabited by Dawan tribes is a vernacular village and organized based on local resources (physical-natural, technological, economic, social and cultural) fully. It is believed that even the ancestral spirits were involved in structuring settlements and the process of village life. The Kaenbaun's culture is a mixture of Dawan culture and the faith and dogma of the Catholic church which form Kaenbaun's wisdom and underlie the behavior of citizens and the spatial layout of Kaenbaun's settlements. The study was conducted by using field observation guided by Husserlian phenomenological paradigm. The data were processed based on inductive-qualitative thinking by using the field notes taken from field research activities in 2004 to 2010. Data were also supplemented by actual information gathered in 2010-2018 through digital media. The result showed that the local wisdom of Kaenbaun (Kaenbaun's wisdom) emerged from the Dawan culture with the acculturation of Catholic faith and dogma becoming a guideline for the behavior of citizens and the spatial structure of the Kaenbaun village settlement architecture. The Kaenbaun's wisdom is the concept of Kaenbaun's ideal life where humans live in harmony with their fellow humans, harmony with nature, blessed by their ancestors and blessed by God.
Postural disorders in patients with vibration disease
Authors: Vasileva Larisa S. , Slivnitsyna Natalya V. , Lakhman Oleg L. 
Published: May 2019

Introduction. Vibration disease (VD) is one of the leading occupational diseases. One of the manifestations of this disease when exposed to general vibration may be a violation of balance.The aim of the study is to identify the imbalance and the causes of their occurrence in patients with vibration disease.Materials and methods. 3 groups of patients were examined. The first group consisted of 50 patients diagnosed with VD associated with combined exposure to local and general vibration (age 48.7±3.1 years); the second group consisted of 50 patients diagnosed with VD associated with exposure to local vibration (age 48.9+2.8 years); the control group consisted of 50 relatively healthy men not in contact with vibration (age 49.1+2.5 years). Survey on electronic stabilometer ST–150 (Biomera, Russia). Patients performed the Romberg test standing barefoot vertically on a stabilometric platform with a “European” stop position. Statistical processing of the results was carried out using the software package “Statistica 10.0” (StatSof, USA, 2011). Methods of descriptive statistics included estimation of median, lower and upper quartiles. The statistical significance of the differences was determined using the nonparametric Wilkinson method. Differences were considered statistically significant at p<0.05.Results. In the analysis of the obtained stabilometric parameters found that in the first group of patients marked imbalance.Moreover, in comparison with the second group and the control group in the phase with eyes closed, patients are more difficult to maintain a given posture, which increases the length of statokinesigram (p=0.02 and p=0.005), increasing the speed of movement of the center of pressure (p=0.03 and p=0.004) and the square of the deviation of the center of pressure (p=0.03 and p=0.004). When closing the eyes, patients put more effort to maintain balance, which affects the rate of mechanical work (p=0.001 and p=0.001). When comparing the second group with the control group, no statistically significant difference was found in the main stabilometric indicators.Conclusions: In the group of patients with VD associated with the combined effects of local and general vibration, marked (64%) and moderate (36%) postural disorders, especially in the phase of closed eyes. In the group of patients with VS associated with local vibration exposure and in the control group, imbalance was detected in 10% and 6%, respectively. The leading role in the occurrence of postural disorders in patients with VD, associated with the combined effects of local and general vibration, plays the formation of a focus of stagnant excitation in the centers of vibration sensitivity. In the future, the pulse can spread to nearby centers of pain, temperature sensitivity and proprioception, which contributes to the emergence of lower limb polyneuropathy and impaired stability in patients with vibration disease.
Higher estimation, lower harvesting: case of NTFPs from Dhaulagiri region, Nepal
Authors: Paudel G. , Acharya R. 
Published: May 2019

In Nepal, non-timber forest products (NTFPs) have high potentiality in contributing to local and national economy. Studies have shown that the potentiality of NTFPs has not been realized yet. This paper aims to explore the number of NTFPs species and quantity collected against the number of NTFPs species and quantity specified in the five year forest management plans of three districts (Baglung, Parbat and Myagdi) in Dhaulagiri region. The data related to number of NTFPs species and the quantity collected in fiscal year 2016/2017 were acquired from three District Forest Offices (Baglung, Parbat and Myagdi) and compared them as specified in the five year forest management plans. The NTFPs species specified for collection in the plans were 90 in Baglung, 50 in Myagdi and 13 in Parbat district. Only 21 species from Baglung, 16 species from Myagdi and none species from Parbat were collected in fiscal year 2016/2017. The annual total quantity of the NTFPs specified in the plans of three districts was 454.21 tons with the royalty of US$ 78,500. But the harvested quantity of NTFPs was only 31.18 tons with the royalty of US$ 4,610 in fiscal year 2016/2017. The quantity of harvested NTFPs was 9.59% and 3.64% of their supply potential in Baglung and Myagdi districts, respectively, while there was no collection of NTFPs from Parbat district. On an average, only 6.87% of NTFPs specified in the plans were collected, generating only 5.87% of the total royalty specified in the plans. The study revealed that remoteness of the area, lower quantity of NTFPs for commercial harvesting and lack of site specific plan of NTFPs are the major causes for under harvesting. Networking of local people and NTFPs traders and formulating site and species specific NTFPs conservation, management and utilization plan are necessary to collect NTFPs in a sustainable manner from these districts.
High frequency of low-virulent microorganisms detected by sonication of pedicle screws: a potential cause for implant failure
Authors: Prinz Vincent , Bayerl Simon , Renz Nora , Trampuz Andrej , Czabanka Marcus , Woitzik Johannes , Vajkoczy Peter , Finger Tobias 
Published: May 2019

OBJECTIVELoosening of pedicle screws is a frequent complication after spinal surgery. Implant colonization with low-virulent microorganisms forming biofilms may cause implant loosening. However, the clinical evidence of this mechanism is lacking. Here, the authors evaluated the potential role of microbial colonization using sonication in patients with clinical pedicle screw loosening but without signs of infection.METHODSAll consecutive patients undergoing hardware removal between January 2015 and December 2017, including patients with screw loosening but without clinical signs of infection, were evaluated. The removed hardware was investigated using sonication.RESULTSA total of 82 patients with a mean (± SD) patient age of 65 ± 13 years were eligible for evaluation. Of the 54 patients with screw loosening, 22 patients (40.7%) had a positive sonication result. None of the 28 patients without screw loosening who served as a control cohort showed a positive sonication result (p < 0.01). In total, 24 microorganisms were detected in those 22 patients. The most common isolated microorganisms were coagulase-negative staphylococci (62.5%) and Cutibacterium acnes (formerly known as Propionibacterium acnes) (25%). When comparing only the patients with screw loosening, the duration of the previous spine surgery was significantly longer in patients with a positive microbiological result (288 ± 147 minutes) than in those with a negative result (201 ± 103 minutes) (p = 0.02).CONCLUSIONSThe low-virulent microorganisms frequently detected on pedicle screws by using sonication may be an important cause of implant loosening and failure. Longer surgical duration increases the likelihood of implant colonization with subsequent screw loosening. Sonication is a highly sensitive approach to detect biofilm-producing bacteria, and it needs to be integrated into the clinical routine for optimized treatment strategies.