bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporary Segmental Distraction in a Dog with Degenerative Lumbosacral Stenosis
Authors: Willems Nicole , Kersten Roel , van Gaalen Steven , Öner F. , Strijkers Gustav , Veraa Stefanie , Beukers Martijn , Tryfonidou Marianna , Meij Björn 
Published: June 2018

Objectives Degenerative lumbosacral stenosis (DLSS) is characterized by intervertebral disc degeneration and causes lower back pain in dogs. Temporary distraction in rabbit models with induced intervertebral disc degeneration showed signs of intervertebral disc repair. In the present study, we assessed safety and efficacy of temporary segmental distraction in a dog with clinical signs of DLSS.
Methods Distraction of the lumbosacral junction by pedicle screw–rod fixation was applied in a 5-year-old Greyhound with DLSS and evaluated by radiography, magnetic resonance imaging, and force plate analysis before and after distraction.
Results Safe distraction of the lumbosacral junction was demonstrated, with improvement of clinical signs after removal of the distraction device. Signal intensity of the intervertebral disc showed no changes over time. T2 value was highest directly after removal of the distraction device but decreased by 10% of the preoperative value at 9 months of follow-up. Disc height decreased (8%) immediately after removal of the distraction device, but recovered to the initial value. A decrease in the pelvic/thoracic propulsive force during pedicle screw–rod fixation and distraction was demonstrated, which slowly increased by 4% compared with the initial value.
Clinical significance Temporary pedicle screw–rod fixation in combination with distraction in a dog with DLSS was safe, improved clinical signs and retained disc height at 9 months of follow-up.
Percutaneous Pulmonary Embolism Thrombectomy and Thrombolysis: Technical Tips and Tricks
Authors: Devcic Zlatko , Kuo William 
Published: June 2018

AbstractCatheter-directed therapy (CDT) is now acknowledged as a treatment option for select patients with acute massive or submassive pulmonary embolism (PE), and more patients are being considered for CDT if there is available expertise. Therefore, interventionalists should be aware of the variety of catheter-based treatment options, specific pitfalls to avoid during therapy, and the appropriate treatment endpoints. This article reviews currently available techniques and protocols for treating acute massive and submassive PE, with tips to safely and successfully perform percutaneous PE interventions.
Magnetic Resonance Imaging Assessment of Intra-Articular Structures in the Canine Stifle Joint after Implantation of a Titanium Tibial Plateau Levelling Osteotomy Plate
Authors: Gerwing Martin , Failing Klaus , Peppler Christine , Kása Andreas , Kramer Martin , von Pückler Kerstin , Feichtenschlager Christian 
Published: June 2018

Objectives To determine the effectiveness of magnetic resonance imaging (MRI) in the evaluation of anatomical stifle structures with respect to implant positioning after tibial plateau levelling osteotomy (TPLO) using a titanium plate.
Methods Selected sagittal and dorsal sequences of pre- and postoperative MRI (1.0 T scanner) of 13 paired (n = 26) sound cadaveric stifle joints were evaluated. The effect of susceptibility artifact on adjacent anatomical stifle structures was graded from 0 to 5. The impact of implant positioning regarding assessment score was calculated using Spearman's rank correlation coefficient.
Results Sagittal turbo spin echo (TSE)-acquired images enabled interpretation of most soft tissue, osseous and cartilage structures without detrimental effect of susceptibility artifact distortions. In T2-weighted TSE images, the cranial cruciate ligament and caudal horn of the medial meniscus could be evaluated, independent of implant position, without any susceptibility artifact in all specimens. T2-weighted fast field echo, water selective, balanced fast field echo and short tau inversion recovery were most markedly affected by susceptibility artifact.
Clinical Significance In selected TSE sequences, MRI allows evaluation of critical intra-articular structures after titanium TPLO plate implantation. Further investigations with confirmed stifle pathologies in dogs are required, to evaluate the accuracy of MRI after TPLO in clinical cases in this context.
Medium- and Large-Sized Autologous Breast Reconstruction using a Fleur-de-lys Profunda Femoris Artery Perforator Flap Design: A Report Comparing Results with the Horizontal Profunda Femoris Artery Perforator Flap
Authors: Lhuaire Martin , Haddad Kevin , Wirz Francesco-Saverio , Abedalthaqafi Samah , Obadia Déborah , Derder Mohamed , Marchac Alexandre , Benjoar Marc , Hivelin Mikael , Lantieri Laurent , Hunsinger Vincent 
Published: June 2018

Background The volume of the profunda femoris artery perforator (PAP) flap limits its indications to small- and medium-sized breast reconstructions after modified radical mastectomy for cancer. We report a modified PAP flap design, including not only a vertical extension that increases its volume but also the skin surface, which suits larger breasts requiring immediate or delayed breast reconstructions and compare the results with our horizontal skin paddle PAP flap experience.
Patients and Methods In our center between November 2014 and November 2016, 51 consecutive patients underwent a PAP flap breast reconstruction following breast cancer. A retrospective analysis on the collected data was performed to compare 34 patients with a bra cup smaller than C who underwent 41 horizontal PAP flap procedures, with those (n = 17) of a bra cup greater than or equal to C who underwent 21 fleur-de-lys PAP flap procedures. Demographic, anthropometric, flap and surgical characteristics, postoperative complication rates, and hospital stay were compared between the two groups.
Results The average flap weight was 480 g (range: 340–735 g) for the fleur-de-lys PAP flap group compared with 222 g (range: 187–325 g) for the horizontal PAP flap procedure (p < 0.001). The mean flap dimensions were 25 × 18 cm for the fleur-de-lys PAP flap group compared with 25 × 7 cm in the horizontal PAP flap group. No flap failure was observed in the fleur-de-lys PAP flap group compared with two flap failures secondary to venous thrombosis in the horizontal PAP flap group (NS). Three patients (14%) experienced delayed healing at the donor site compared with four patients (10%) in the horizontal PAP flap group (NS).
Conclusion The fleur-de-lys skin paddle design not only allows an increase of the horizontal PAP flap volume, but also increases the skin surface, with an acceptable donor site morbidity. For medium- or large-sized breasts, the fleur-de-lys PAP flap seems to be ideal when a DIEP flap-based reconstruction is contraindicated.
Chronic Thromboembolic Pulmonary Hypertension
Authors: Pretorius G. , Jamieson Stuart 
Published: June 2018

AbstractChronic thromboembolic pulmonary hypertension occurs when acute thromboemboli fail to dissolve completely. The resulting fibrotic scar tissue within the pulmonary arteries is obstructive and eventually leads to right heart failure. Medical therapy for this condition is supportive, but surgery with pulmonary artery endarterectomy is curative, and carries a low mortality at experienced centers.
Intra- and Inter-observer Variability of Measurements of the Laxity Index on Stress Radiographs Performed with the Vezzoni-Modified Badertscher Hip Distension Device
Authors: Vezzoni Aldo , Houdellier Blandine , Bogaerts Evelien , Stock Emmelie , Polis Ingeborgh , Deforce Dieter , Saunders Jimmy , Broeckx Bart , Bertal Mileva 
Published: June 2018

Objectives To describe and evaluate the accuracy, intra- and inter-observer variability of the laxity index (LI), used to quantify hip laxity on stress radiographs obtained with the Vezzoni-modified Badertscher distension device (VMBDD).
Methods Stress radiographs of 10 dogs obtained with the VMBDD were measured three times by an experienced observer. Six participants with different backgrounds (two ECVDI residents, two PhD students, two veterinary assistants) followed a short presentation and performed subsequently the measurements four times in two separate sessions. The effect of self-learning, feedback and specialization on the accuracy of the measurements was assessed.
Results While the intra- and inter-observer variability were in agreement with other studies, the results of the experienced observer indicated that the variability can be very low. Neither feedback nor self-learning improved the results. A high degree of experience in radiographic assessment was not necessary to perform the measurements correctly.
Clinical Significance As the LI measurements were acceptable after a short presentation, they support the use of VMBDD for a complete and correct in-house evaluation of the hip joint by trained clinicians. However, we propose that, in the context of screening, measurements should be performed by a limited number of experienced examiners, to limit the impact of the inter-observer variability.
Procalcitonin-Guided Therapy for Reduction of Antibiotic Use in Patients with Bronchiolitis
Authors: Bayoglu Duygu , Eker Pinar , Guven Sirin 
Published: June 2018

Objective Procalcitonin (PCT)-guided treatment could reduce antibiotic use in viral lower respiratory tract infections. We evaluated the impact of PCT-guided treatment on antibiotic use in patients hospitalized with bronchiolitis.
Study Design A total of 100 patients aged 1 to 24 months old who were hospitalized with bronchiolitis were included in the study. Patients were randomized into two groups: PCT-guided group received an antibiotic treatment based on PCT levels and control group received an antibiotic treatment according to the physician decision.
Results Antibiotic use on first day in the PCT-guided group (12%) was found to be statistically significantly lower than in the control group (80%) (p = 0.001; p < 0.05; relative risk [RR]: 29.33; 95% confidence interval [CI]: 9.77–88.03). On the third day, antibiotic use was statistically significantly lower in the PCT-guided group (16%) than in the control group (40%) (p = 0.014; p < 0.05; RR: 3.5; 95% CI: 1.36–9).
Conclusion We suggested that PCT guidance will have important contributions to reduce antibiotic use in children with bronchiolitis. Particularly in countries with higher antibiotic prescription rates, this strategy may have implication for reducing the development of antibiotic resistance and side effects due to disturbance of microbiota.
Modulating cell state to enhance suspension expansion of human pluripotent stem cells
Authors: Lipsitz Yonatan Y. , Woodford Curtis , Yin Ting , Hanna Jacob H. , Zandstra Peter W. 
Published: June 2018

SignificanceEfficient manufacturing is critical for the translation of cell-based therapies to clinical applications. To date, high-yield expansion of human pluripotent stem cells (hPSC) in suspension bioreactors has not been reported. Here, we present a strategy to shift suspension-grown hPSC to a high-yield state without compromising their ability to differentiate to all three germ layers. In this new state, hPSC expand to densities 5.7 ± 0.2-fold higher than conventional hPSC each passage in suspension bioreactors. High-density suspension cultures enable process intensification, cost reduction, and more efficient manufacturing. This work advances cell-state engineering as a valuable tool to overcome current challenges in therapeutic cell production and processing.
Potassic, high-silica Hadean crust
Authors: Boehnke Patrick , Bell Elizabeth A. , Stephan Thomas , Trappitsch Reto , Keller C. Brenhin , Pardo Olivia S. , Davis Andrew M. , Harrison T. Mark , Pellin Michael J. 
Published: June 2018

Significance
To understand early Earth’s habitability, we need to know when the continental crust first formed. However, due to the combined actions of plate tectonics and erosion, most of the evidence of the early crust has been destroyed. To shed light on this debate, we analyzed the strontium isotopic composition of apatite inclusions in zircons from Nuvvuagittuq, Canada, where independent evidence suggests a crust-forming event prior to 4.2 Ga, possibly as early as 4.4 Ga. Our results show that this early crust had a high Rb/Sr ratio and therefore a high silica content. This suggests that the early Earth was capable of forming continental crust within <350 million y of solar system formation.
Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging
Authors: Margulis Katherine , Chiou Albert S. , Aasi Sumaira Z. , Tibshirani Robert J. , Tang Jean Y. , Zare Richard N. 
Published: June 2018

Significance
Timely detection of microscopic tumors is of utmost importance in cancer diagnostics. We show that desorption electrospray ionization mass spectrometry imaging (DESI-MSI) can successfully locate microscopic aggregates of a common skin cancer, basal cell carcinoma (BCC), and distinguish them from adjacent normal skin. DESI-MSI unveils an altered chemical profile in BCC region, including lipids and metabolites, and does not rely on visual identification of histopathologic features. We processed specimens from 86 Mohs micrographic surgeries, with nearly 60% of tumors sized less than 1 mm in diameter. By applying the statistical method of least absolute shrinkage and selection operator (Lasso) on collected DESI-MSI data, we were able to achieve up to 94.1% diagnostic accuracy compared with pathological evaluation of BCC.
Multi-method research
Authors: Tuominen Tiina 
Published: June 2018

Abstract
This chapter discusses research approaches that investigate reception in its context, both the audiovisual context in which the translation appears and the social context in which it is being viewed. The studies introduced in this chapter include thematic studies which focus on examining the viewers’ interpretations of a specific aspect of the translated programme, as well as wide-ranging studies which explore viewers’ attitudes and expectations towards audiovisual translations. The methods introduced in the chapter include questionnaires with qualitative and quantitative approaches, interviews, focus group research, observation, and some novel research approaches arising from the model of user-centered translation and the concepts of usability and user experience. Finally, the chapter argues for the benefits of large-scale, collective research approaches and replication of research designs in a variety of contexts.
Reception studies in audiovisual translation – interlingual subtitling
Authors: Nikolić Kristijan 
Published: June 2018

Abstract
Interlingual subtitling is the principal way of translating audiovisual content in many countries. It has been descriptively studied by scholars in numerous books and articles. However, studies attempting to tackle this phenomenon empirically, such as reception studies, have been scarce until recently, and only over the last couple of years have such studies become more common. The reason for the relative scarcity of empirical research in interlingual subtitling is its complexity. Finding the right subjects, using the adequate technology and obtaining funding may be a complicated and lengthy process. For instance, eye tracking technology started to be used only recently in studies that offered scholars concrete findings about viewers’ reception. But is eye tracking the only valid research method? This chapter follows the developments in empirical research into interlingual subtitling, introducing the findings of such research and suggesting future directions.
On the reception of mobile content
Authors: Fernández Costales Alberto 
Published: June 2018

Abstract
The reception of translated audiovisual contents in mobile devices has been largely ignored in Translation Studies. The current chapter is intended to identify key areas and challenges for research in Audiovisual Translation, so we can have a better understanding of how mobile contents are received and appreciated by users. Research in this field is modulated by the hybridity of audiovisual texts in mobile phones, since this type of text is multimodal, multichannel, and multiplatform. A second challenge is the potential target of mobile contents: the notion of audience(s) needs to be revisited in the new scenario, where ubiquity, immediacy, and global access to digital contents have sparked the diversification of users’ profiles. The spotlight of this chapter is on research opportunities within the reception of mobile contents; the complexity of investigating new types of global audiences clearly demands interdisciplinary approaches and research designs.
Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048
Authors: Matsuzaki Chiaki , Takagaki Chikahiro , Higashimura Yasuki , Nakashima Yukari , Hosomi Koji , Kunisawa Jun , Yamamoto Kenji , Hisa Keiko 
Published: June 2018

ABSTRACT
This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.
Workload and non‐contact injury incidence in elite football players competing in European leagues
Authors: Delecroix Barthelemy , McCall Alan , Dawson Brian , Berthoin Serge , Dupont Gregory 
Published: June 2018

AbstractPurpose: The aim of this study was to analyse the relationship between absolute and acute:chronic workload ratios and non‐contact injury incidence in professional football players and to assess their predictive ability. Methods: Elite football players (n = 130) from five teams competing in European domestic and confederation level competitions were followed during one full competitive season. Non‐contact injuries were recorded and using session rate of perceived exertion (s‐RPE) internal absolute workload and acute:chronic (A:C) workload ratios (4‐weeks, 3‐weeks, 2‐weeks and week‐to‐week) were calculated using a rolling days method. Results: The relative risk (RR) of non‐contact injury was increased (RR = 1.59, CI95%: 1.18–2.15) when a cumulative 4‐week absolute workload was greater than 10629 arbitrary units (AU) in comparison with a workload between 3745 and 10628 AU. When the 3‐week absolute workload was more than 8319 AU versus between 2822 and 8318 AU injury risk was also increased (RR= 1.46, CI95% 1.08–1.98). Injury incidence was higher when the 4‐week A:C ratio was <0.85 versus >0.85 (RR = 1.31, CI95%: 1.02–1.70) and with a 3‐week A:C ratio >1.30 versus <1.30 (RR = 1.37, CI95%: 1.05–1.77). Importantly, none of the A:C workload combinations showed high sensitivity or specificity. Conclusions: In elite European footballers, using internal workload (sRPE) revealed that cumulative workloads over 3 and 4 weeks were associated with injury incidence. Additionally, A:C workloads, using combinations of 2, 3 and 4 weeks as the C workloads were also associated with increased injury risk. No A:C workload combination was appropriate to predict injury.
The final report for APMP.M.M-K6.1: key comparison of 50 kg stainless steel mass standard
Authors: Lee Sungjun , Becerra Luis Omar , Zhong Ruilin 
Published: June 2018

This report describes the result of an Asia Pacific Metrology Programme (APMP) regional comparison of 50 kg stainless steel mass standard carried out among three laboratories as a collaboration among inter-Regional Metrology Organization (RMO) programs. One weight of nominal value 50 kg has been prepared by CENAM (Mexico) of Sistema Interamericano de MetrologÃ­a (SIM) for this APMP comparison as an international collaboration. The reported results by participants are consistent with each other and with the key comparison reference value (KCRV) of comparison, CCM.M-K6 to which this comparison has been linked
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To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
A Comparison of Strains Induced by Manufacturing and Operational Conditions of a Tantalum Clad Tungsten Plate of an ISIS TS1 Solid Target
Authors: Ma Yanling , Jenkins David , Kabra Saurabh , Zhang Shu Yan 
Published: June 2018

Abstract
This paper aims to reveal the relationship between two sets of residual strains. One set of the strains were induced by manufacturing when the Tantalum (Ta) cladding was diffusion bonded to the Tungsten (W) core by Hot Isostatic Pressing (HIP) process. Another set of strains was induced during target operations, i.e., when the HIPPED target plates were further bombarded by proton beams for neutron production. The former set was revealed by Neutron Diffraction Measurement (NDM) using the ISIS Engin-X instrument. The latter set was obtained via Finite Element Analysis (FEA) on the ISIS TS1 target assembly. The comparison and superposition of these two sets of strains demonstrated mainly an overall reduction of about 50 micro strains within the Ta cladding. Namely, the strains induced during the TS1 target operation could be beneficial for the specific region of target plate number five (P5) in this case.
Silicon chemistry for sustainable development of rice agriculture
Authors: Karyasa I W 
Published: June 2018

AbstractThe literature reviewed paper was aimed to explain the role of paddy’s plantation for reserving silica powder, to explain the current developing of advanced materials from the high siliconeous rice plant biomasses, to propose a scheme of value addition of paddy’s biomasses for sustainable rice agriculture development. A comprehensive literature review through meta analysis on articles published in last few decades was conducted. Because of high silicon content of rice biomasses especially rice straws and husks and their abundance in availability, the rich silicon biomasses can be used as raw material for producing a high purity reactive fine powder silica, and unexpesive and environment-friendly production processes. Current development results on advanced materials from the rich siliconeous biomasses were reported, namely silicon carbides, amorphous reactive silica, nanosilica, and silica-carbon nanocomposite. The implementation of silicon chemistry takes important role for enhancing the added value of rice husks and straws as the side products of paddy’s agriculture to produce some advanced materials inexpensively and environment-friendly. The added values can be considered to overcome the problems of lack paddy’s farmer income and the land conversion tendency of rice field, thus the paddy’s agriculture can be developed sustainably.