bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Authors: Port Jennifer , Muthalagu Nathiya , Raja Meera , Ceteci Fatih , Monteverde Tiziana , Kruspig Björn , Hedley Ann , Kalna Gabriela , Lilla Sergio , Neilson Lisa , Brucoli Martina , Gyuraszova Katarina , Tait-Mulder Jacqueline , Mezna Mokdad , Svambaryte Silvija , Bryson Amy , Sumpton David , McVie Allan , Nixon Colin , Drysdale Martin , Esumi Hiroyasu , Murray Graeme I. , Sansom Owen J. , Zanivan Sara R. , Murphy Daniel J. 
Published: March 2018

Abstract
Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of human cancer, and antioxidant defenses are implicated in resistance to chemotherapy and radiotherapy. Targeted suppression of antioxidant defenses could thus broadly improve therapeutic outcomes. Here, we identify the AMPK-related kinase NUAK1 as a key component of the antioxidant stress response pathway and reveal a specific requirement for this role of NUAK1 in colorectal cancer. We show that NUAK1 is activated by oxidative stress and that this activation is required to facilitate nuclear import of the antioxidant master regulator NRF2: Activation of NUAK1 coordinates PP1β inhibition with AKT activation in order to suppress GSK3β-dependent inhibition of NRF2 nuclear import. Deletion of NUAK1 suppresses formation of colorectal tumors, whereas acute depletion of NUAK1 induces regression of preexisting autochthonous tumors. Importantly, elevated expression of NUAK1 in human colorectal cancer is associated with more aggressive disease and reduced overall survival.
Significance: This work identifies NUAK1 as a key facilitator of the adaptive antioxidant response that is associated with aggressive disease and worse outcome in human colorectal cancer. Our data suggest that transient NUAK1 inhibition may provide a safe and effective means for treatment of human colorectal cancer via disruption of intrinsic antioxidant defenses. Cancer Discov; 8(5); 632–47. ©2018 AACR.
This article is highlighted in the In This Issue feature, p. 517
Female house wrens value the nest cavity more than exclusive access to males during conflicts with female intruders
Authors: Krieg Cara A. , Getty Thomas 
Published: March 2018

AbstractIndividuals should fight hardest when they stand to lose the most. Whereas males frequently compete for fertile females, females more often compete for high quality males, male care, or resources required to breed. We asked whether established, territorial female house wrens (Troglodytes aedon) challenged by simulated female intruders fight as if they place more value on retaining (1) their nesting cavity or (2) exclusive access to other benefits offered by males. We randomly assigned house wren pairs to receive one or three nest boxes and then assayed female aggression. The relative costs to losing differed between box treatments. For one-box females, the risk of losing the cavity and territory was higher. For three-box females, the risk of losing the cavity may be lower because intruders may be able to settle as secondary females in the supplemental boxes. In this situation, females would lose exclusive access to males and their territories but would still retain the male’s assistance rearing offspring since male house wrens favour their oldest brood. We found that one-box females were significantly more aggressive. This response may be adaptive, as females that switched territories between broods were significantly more likely to lose their entire nest prior to hatching than females that retained the same territory. We interpret our results to mean that female house wrens value the nest cavity more than other benefits from exclusive access to males and their territories. This work contributes to a body of evidence that females often compete for resources required to breed.
The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain
Authors: Reshetnikov V.V. , Studenikina A.A. , Ryabushkina J.A. , Merkulova T.I. , Bondar N.P. 
Published: March 2018

Abstract
Early life is an important period for the development of the nervous system and for the programming of behavioural phenotypes in adulthood. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 h/day, maternal separation (MS)) and brief separation (for 15 min/day, handling (HD)). We analysed the effects of early-life stress on behaviour and the expression of HPA-associated genes in the hypothalamus, hippocampus, and frontal cortex of male mice. Adult mice in the MS group demonstrated reduced locomotor activity and deficiencies in spatial long-term memory, while the HD showed no significant changes. Additionally, early-life MS resulted in reduced hippocampal Crhr1 mRNA, increased MR/GR mRNA in the hippocampus and hypothalamus. Both groups, HD and MS, showed increased Avp mRNA in the hypothalamus. Thus, prolonged maternal separation but not brief leads to adverse behavioural changes and influences the expression of HPA-associated genes in a brain region-specific manner.
The Nocturnal Evolution of Atmospheric Structure in a Basin as a Larger-Scale Katabatic Flow Is Lifted over Its Rim
Authors: Whiteman C. David , Lehner Manuela , Hoch Sebastian W. , Adler Bianca , Kalthoff Norbert , Vogt Roland , Feigenwinter Iris , Haiden Thomas , Hills Matthew O. G. 
Published: March 2018

AbstractThe successive stages of nocturnal atmospheric structure inside a small isolated basin are investigated when a katabatically driven flow on an adjacent tilted plain advects cold air over the basin rim. Data came from Arizona’s Meteor Crater during intensive observing period 4 of the Second Meteor Crater Experiment (METCRAX II) when a mesoscale flow above the plain was superimposed on the katabatic flow leading to a flow acceleration and then deceleration over the course of the night. Following an overflow-initiation phase, the basin atmosphere over the upwind inner sidewall progressed through three stages as the katabatic flow accelerated: 1) a cold-air-intrusion phase in which the overflowing cold air accelerated down the upwind inner sidewall, 2) a bifurcation phase in which the katabatic stable layer lifted over the rim included both a nonnegatively buoyant upper layer that flowed horizontally over the basin and a negatively buoyant lower layer (the cold-air intrusion) that continued on the slope below to create a hydraulic jump at the foot of the sidewall, and 3) a final warm-air-intrusion phase in which shear instability in the upper overflowing layer produced a lee wave that brought warm air from the elevated residual layer downward into the basin. Strong winds during the third phase penetrated to the basin floor, stirring the preexisting, intensely stable, cold pool. Later in the night a wind direction change aloft decelerated the katabatic wind and the atmosphere progressed back through the bifurcation and cold-air-intrusion phases. A conceptual diagram illustrates the first four evolutionary phases.
Erroneous Attribution of Deep Convective Invigoration to Aerosol Concentration
Authors: Varble Adam 
Published: March 2018

Abstract
Contiguous time–height cloud objects at the Department of Energy Atmospheric Radiation Measurement Southern Great Plains (SGP) site are matched with surface condensation nuclei (CN) concentrations and retrieved thermodynamic and kinematic vertical profiles for warm-cloud-base, cold-cloud-top systems in convectively unstable environments. Statistical analyses show that previously published conclusions that increasing CN concentrations cause a decrease in minimum cloud-top temperature (CTT) at the SGP site through the aerosol convective invigoration effect are unfounded. The CN–CTT relationship is statistically insignificant, while correlations between convective available potential energy (CAPE), level of neutral buoyancy (LNB), and CN concentration account for most of the change in the CN–CTT positive correlation. Removal of clouds with minimum CTTs &gt; −36°C from the analysis eliminates the CN–CTT correlation. Composited dirty conditions at the SGP have ~1°C-warmer low levels and ~1°C-cooler upper levels than clean conditions. This correlation between aerosol concentrations and thermodynamic profiles may be caused by an increase in regional rainfall preceding deep convective conditions as CN concentration decreases. Increased rainfall can be expected to increase wet deposition of aerosols, cool low-level temperatures, and warm upper-level temperatures. The masking of a potential aerosol effect by such small thermodynamic changes implies that the strategy of analyzing subsets of aerosol data by binned meteorological factor values is not a valid method for discerning an aerosol effect in some situations. These findings highlight the need for more careful, detailed, and strategic observations to confidently isolate and quantify an aerosol deep convective invigoration effect.
A Diagnostic Study of the Evolution of the MJO from Indian Ocean to Maritime Continent: Wave Dynamics versus Advective Moistening Processes
Authors: Hung Ching-Shu , Sui Chung-Hsiung 
Published: March 2018

AbstractThe evolution processes for propagating Madden–Julian oscillations with strong magnitude over the Indian Ocean (IO) and Maritime Continent (MC) are investigated through a diagnosis of ECMWF reanalysis data for November–April 1982–2011. A scale-separated lower-tropospheric (1000–700 hPa) moisture budget is analyzed for four stages of composite life cycle: suppressed, cloud developing, convective, and decaying. Overall, the budgets in the IO and MC are dominated by wave-induced boundary layer convergence in the anomalous easterlies (WC) and advection. Starting from the suppressed stage in the central IO, moistening by WC and advection by easterly anomalies contributes to an initiation of the MJO convection in the western IO while surface evaporation and/or shallow convection moistens the central IO. In the following cloud developing and convective stage in the central IO, moistening by WC and advection by the downstream Kelvin–Rossby wave east of central IO lead to eastward propagation of deep convection. In the MC, the suppressed stage coincides with the convective stage in the central IO that promotes anomalous easterlies, subsidence, and enhanced rain rate over islands. Unlike WC and advective moistening in the IO that both occur in the equatorial zone, advective moistening in MC tends to be negative (positive) on windward (leeward) side of the major islands in the equatorial zone and more organized over the Arafura Sea, conducive to a southward detour of the eastward-propagating MJO.
Evaluation of Spatial and Temporal Performances of ERA-Interim Precipitation and Temperature in Mainland China
Authors: Liu Zhengjia , Liu Yansui , Wang Sisi , Yang Xiujing , Wang Lunche , Baig Muhammad Hasan Ali , Chi Wenfeng , Wang Zhaosheng 
Published: March 2018

AbstractERA-Interim has been widely considered as a valid proxy for observations at global and regional scales. However, the verifications of ERA-Interim precipitation and temperature in mainland China have been rarely conducted, especially in the spatial and long-term performances. Therefore, in this study, we employed the interpolated ground station (STA) data to evaluate the spatial and temporal patterns and trends of ERA-Interim precipitation and temperature during 1980–2012. The results showed that relatively weaker performances were observed in ERA-Interim precipitation, with the skill score (S index) ranging from 0.41 to 0.50. Interannual ERA-Interim precipitation presented comparable trends with STA precipitation at the annual and seasonal scales. Spatial patterns of empirical orthogonal function (EOF) modes and corresponding principal components were evidently different between annual ERA-Interim and STA precipitation. For temperature, annual and seasonal patterns of ERA-Interim data were in good consistency with those of STA over China with the S index ranging from 0.59 to 0.70. Yet interannual STA temperature recorded stronger warming trends (from 0.37 K decade−1 of wintertime to 0.53 K decade−1 of springtime) at the annual and seasonal scales compared to corresponding periods for ERA-Interim temperature (from 0.03 K decade−1 of wintertime to 0.25 K decade−1 of summertime). Overall, ERA-Interim precipitation and temperature had good agreement with STA data in east China with lower elevation (&lt;1000 m above sea level), but good agreements were not observed in west China with higher elevation. The findings suggest that caution should be paid when using ERA-Interim precipitation and temperature in areas with complex orography.
Influence of the Subtropical High and Storm Track on Low-Cloud Fraction and Its Seasonality over the South Indian Ocean
Authors: Miyamoto Ayumu , Nakamura Hisashi , Miyasaka Takafumi 
Published: March 2018

Abstract
The south Indian Ocean is characterized by enhanced midlatitude storm-track activity around a prominent sea surface temperature (SST) front and unique seasonality of the surface subtropical Mascarene high. The present study investigates the climatological distribution of low-cloud fraction (LCF) and its seasonality by using satellite data, in order to elucidate the role of the storm-track activity and subtropical high. On the equatorward flank of the SST front, summertime LCF is locally maximized despite small estimated inversion strength (EIS) and high SST. This is attributable to locally augmented sensible heat flux (SHF) from the ocean under the enhanced storm-track activity, which gives rise to strong instantaneous wind speed while acting to relax the meridional gradient of surface air temperature. In the subtropics, summertime LCF is maximized off the west coast of Australia, while wintertime LCF is distributed more zonally across the basin unlike in other subtropical ocean basins. Although its zonally extended distribution is correspondent with that of LCF, EIS alone cannot explain the wintertime LCF enhancement, which precedes the EIS maximum under continuous lowering of SST and enhanced SHF in winter. Basinwide cold advection associated with the wintertime westward shift of the subtropical high contributes to the enhancement of SHF, especially around 15°–25°S, while seasonally enhanced storm-track activity augments SHF around 30°S. The analysis highlights the significance of large-scale controls, particularly through SHF, on the seasonality of the climatological LCF distribution over the south Indian Ocean, which reflect the seasonality of the Mascarene high and storm-track activity.
Influences of Pacific Climate Variability on Decadal Subsurface Ocean Heat Content Variations in the Indian Ocean
Authors: Jin Xiaolin , Kwon Young-Oh , Ummenhofer Caroline C. , Seo Hyodae , Schwarzkopf Franziska U. , Biastoch Arne , Böning Claus W. , Wright Jonathon S. 
Published: March 2018

Abstract
Decadal variabilities in Indian Ocean subsurface ocean heat content (OHC; 50–300 m) since the 1950s are examined using ocean reanalyses. This study elaborates on how Pacific variability modulates the Indian Ocean on decadal time scales through both oceanic and atmospheric pathways. High correlations between OHC and thermocline depth variations across the entire Indian Ocean Basin suggest that OHC variability is primarily driven by thermocline fluctuations. The spatial pattern of the leading mode of decadal Indian Ocean OHC variability closely matches the regression pattern of OHC on the interdecadal Pacific oscillation (IPO), emphasizing the role of the Pacific Ocean in determining Indian Ocean OHC decadal variability. Further analyses identify different mechanisms by which the Pacific influences the eastern and western Indian Ocean. IPO-related anomalies from the Pacific propagate mainly through oceanic pathways in the Maritime Continent to impact the eastern Indian Ocean. By contrast, in the western Indian Ocean, the IPO induces wind-driven Ekman pumping in the central Indian Ocean via the atmospheric bridge, which in turn modifies conditions in the southwestern Indian Ocean via westward-propagating Rossby waves. To confirm this, a linear Rossby wave model is forced with wind stresses and eastern boundary conditions based on reanalyses. This linear model skillfully reproduces observed sea surface height anomalies and highlights both the oceanic connection in the eastern Indian Ocean and the role of wind-driven Ekman pumping in the west. These findings are also reproduced by OGCM hindcast experiments forced by interannual atmospheric boundary conditions applied only over the Pacific and Indian Oceans, respectively.
A Dynamical Initialization Scheme for Tropical Cyclones under the Influence of Terrain
Authors: Liu Hao-Yan , Wang Yuqing , Xu Jing , Duan Yihong 
Published: March 2018

Abstract
This study extends an earlier dynamical initialization (DI) scheme for tropical cyclones (TCs) to situations under the influence of terrain. When any terrain lower than 1 km exists between 150 and 450 km from the TC center, topographic variables are defined and a filtering algorithm is used to remove noise due to the presence of terrain before the vortex separation is conducted. When any terrain higher than 1 km exists between 150 and 300 km from the TC center, or the TC center is within 150 km of land, a semi-idealized integration without the terrain is conducted to spin up an axisymmetric TC vortex before the inclusion of the terrain and the merging of the TC vortex with the large-scale analysis field. In addition, a procedure for the vortex size/intensity adjustment is introduced to reduce the initial errors before the forecast run. Two sets of hindcasts, one without (CTRL run) and one with the new DI scheme (DI run), are conducted for nine TCs affected by terrain over the western North Pacific in 2015. Results show that the new DI scheme largely reduces the initial position and intensity errors. The 72-h position errors and the intensity errors up to the 36-h forecasts are smaller in DI runs than in CTRL runs and smaller than those from the HWRF forecasts for the same TCs as well. The new DI scheme is also shown to produce the TC inner-core structure and rainbands more consistent with satellite and radar observations.
Development of a Human–Machine Mix for Forecasting Severe Convective Events
Authors: Karstens Christopher D. , Correia James , LaDue Daphne S. , Wolfe Jonathan , Meyer Tiffany C. , Harrison David R. , Cintineo John L. , Calhoun Kristin M. , Smith Travis M. , Gerard Alan E. , Rothfusz Lans P. 
Published: March 2018

Abstract
Providing advance warning for impending severe convective weather events (i.e., tornadoes, hail, wind) fundamentally requires an ability to predict and/or detect these hazards and subsequently communicate their potential threat in real time. The National Weather Service (NWS) provides advance warning for severe convective weather through the issuance of tornado and severe thunderstorm warnings, a system that has remained relatively unchanged for approximately the past 65 years. Forecasting a Continuum of Environmental Threats (FACETs) proposes a reinvention of this system, transitioning from a deterministic product-centric paradigm to one based on probabilistic hazard information (PHI) for hazardous weather events. Four years of iterative development and rapid prototyping in the National Oceanic and Atmospheric Administration (NOAA) Hazardous Weather Testbed (HWT) with NWS forecasters and partners has yielded insights into this new paradigm by discovering efficient ways to generate, inform, and utilize a continuous flow of information through the development of a human–machine mix. Forecasters conditionally used automated object-based guidance within four levels of automation to issue deterministic products containing PHI. Forecasters accomplished this task in a timely manner while focusing on communication and conveying forecast confidence, elements considered necessary by emergency managers. Observed annual increases in the usage of first-guess probabilistic guidance by forecasters were related to improvements made to the prototyped software, guidance, and techniques. However, increasing usage of automation requires improvements in guidance, data integration, and data visualization to garner trust more effectively. Additional opportunities exist to address limitations in procedures for motion derivation and geospatial mapping of subjective probability.
How belief in a just world might shape responses to discrimination: A case study of left-behind children in China
Authors: Lan Tian , Jia Xuji , Liu Xia 
Published: March 2018

Background: Previous study has indicated that perceived discrimination affected the children’s behaviors, but whether belief in a just world moderates the relationship between perceived discrimination and problem behaviors among left-behind children and whether there are differences between boys and girls are still unknown. Aims: This study aims at exploring whether perceived discrimination influences the left-behind children’s behaviors and the moderating role of belief in a just world among both boys and girls. Methods: Using cross-sectional data on rural left-behind children in Henan Province of China, this study examined the relationships among perceived discrimination (personal and group), belief in a just world and problem behaviors for both boys and girls. The participants included 336 boys and 310 girls. Self-report questionnaires captured perceived discrimination, belief in a just world and problem behaviors. Results: The results demonstrated that Chinese left-behind boys who perceived a high amount of personal discrimination were prone to exhibit problem behaviors. Yet, neither perceived personal nor group discrimination was associated with problem behaviors among the left-behind girls. Moreover, the children’s belief in a just world moderated the association between perceived discrimination and problem behaviors among the boys; in those who reported higher levels of belief in a just world, the negative effect of perceived personal discrimination on problem behaviors appeared weaker, comparing to those who reported lower levels of belief in a just world. In addition, the negative effect of perceived group discrimination on problem behaviors appeared stronger among the left-behind boys who reported higher levels of belief in a just world. Conclusion: Belief in a just world provided a protect function for the left-behind children when facing perceived personal discrimination. More attention should be paid on belief in a just world, perceived discrimination and problem behaviors among left-behind children.