bluuebunny/crossref_metadata_2025_split huggingface dataset:
A brief intervention to enhance breast cancer clinicians' communication about sexual health: Feasibility, acceptability, and preliminary outcomes
Authors: Reese Jennifer Barsky , Lepore Stephen J. , Daly Mary B. , Handorf Elizabeth , Sorice Kristen A. , Porter Laura S. , Tulsky James A. , Beach Mary Catherine 
Published: February 2019

AbstractObjectiveSexual concerns are often unaddressed for breast cancer patients; one reason is inadequate clinician training. We examined the feasibility, acceptability, and potential benefits of a novel intervention, improving Sexual Health and Augmenting Relationships through Education (iSHARE) for breast cancer clinicians.MethodsClinicians received training in communicating about sexual concerns with breast cancer patients. Intervention feasibility and acceptability were measured through enrollment/participation and postintervention program evaluations, respectively. Intervention effects were assessed through (1) clinician self‐reported beliefs about sexual health communication, assessed at baseline, post‐intervention, and 1‐ or 6‐month follow‐up, (2) clinical communication coded from audio recorded, transcribed clinic encounters at preintervention or postintervention, and (3) patient satisfaction with clinical care, reported immediately after the clinic visit. Patients also reported sociodemographic characteristics and level of sexual concerns.ResultsSeven breast cancer clinicians enrolled (88% participation), completed the intervention, and were audio recorded in clinic encounters with 134 breast cancer outpatients (67 each at preintervention or postintervention). Program evaluations supported intervention acceptability. Effect sizes suggest iSHARE increased clinicians' self‐efficacy (d = 0.27) and outcome expectancies for communicating about sexual concerns (d = 0.69) and reduced communication barriers (d = −0.14). Clinicians' sexual health communication behaviors increased from baseline to postintervention, including for raising the topic (28% vs 48%), asking questions (33% vs 45%), and offering information (18% vs 24%). Neither patient satisfaction nor duration of sexual health communication changed (mean duration less than 1 minute at both time points).ConclusionsThe iSHARE intervention was feasible and well received by clinicians and may change breast cancer clinicians' beliefs and communication behaviors regarding sexual health.
Current status and advances in arginine‐glycine‐aspartic acid peptide‐based molecular imaging to evaluate the effects of anti‐angiogenic therapies
Authors: Cui Jin , Yue Jin Bo 
Published: February 2019

AbstractIt is known that tumor growth, invasion, and metastasis are all dependent on tumor angiogenesis. Persistent angiogenesis is a characteristic of malignant tumors. Quantification of neovascularization in malignant tumors is considered to be an important independent prognostic marker. Integrin αvβ3 plays an important role in angiogenesis and tumor metastasis. Arginine‐glycine‐aspartic acid (RGD) peptides can specifically bind to integrin αvβ3. Radiolabeled RGD molecular probes can be used to visualize tumor blood vessels, monitor their changes before and after anti‐angiogenic treatment, and predict the curative effect of anti‐angiogenic drugs. As a highly specific marker, the radiolabeled RGD peptide can be used for molecular imaging of malignant tumors, and serve as a tool for early diagnosis, treatment, and detection of anti‐angiogenesis effects in tumors. The method is gradually beginning to be applied in research and clinical angiography for visualization of various tumors. Results obtained in some animal experiments and clinical trials have verified the effectiveness of radiolabeled RGD peptide imaging for the evaluation of anti‐angiogenic therapy efficacy. However, to verify the feasibility of this method and to extensively implement it, more in‐depth clinical and preclinical trials are required.
Inhibition of the CXCL12/CXCR4 axis prevents periurethral collagen accumulation and lower urinary tract dysfunction in vivo
Authors: Macoska Jill A. , Wang Zunyi , Virta Johanna , Zacharias Nicholas , Bjorling Dale E. 
Published: February 2019

AbstractBackgroundSeveral studies show that prostatic fibrosis is associated with male lower urinary tract dysfunction (LUTD). Development of fibrosis is typically attributed to signaling through the transforming growth factor β (TGF‐β) pathway, but our laboratory has demonstrated that in vitro treatment of human prostatic fibroblasts with the C‐X‐C motif chemokine ligand 12 (CXCL12) chemokine stimulates myofibroblast phenoconversion and that CXCL12 has the capacity to activate profibrotic pathways in these cells in a TGF‐β‐independent manner. We have previously reported that feeding mice high‐fat diet (HFD) results in obesity, type II diabetes, increased prostatic fibrosis, and urinary voiding dysfunction. The purpose of this study was to test the hypothesis that in vivo blockade of the CXCL12/CXCR4 axis would inhibit the development of fibrosis‐mediated LUTD in HFD‐fed mice.MethodsTwo‐month‐old male senescence‐accelerated mouse prone‐6 mice were fed either a HFD or low‐fat diet (LFD) for 8 months. Half of each dietary group were given constant access to normal water or water that contained the C‐X‐C chemokine receptor type 4 (CXCR4; CXCL12 receptor) antagonist CXCR4AIII. At the conclusion of the study, mice were weighed, subjected to oral glucose tolerance testing and cystometry, and lower urinary tract tissues collected and assessed for collagen content.ResultsHFD‐fed mice became significantly obese, insulin resistant, and hyperglycemic, consistent with acquisition of metabolic syndrome, compared with LFD‐fed mice. Anesthetized cystometry demonstrated that HFD‐fed mice experienced significantly longer intercontractile intervals and greater functional bladder capacity than LFD‐fed mice. Immunohistochemistry demonstrated high levels of CXCR4 and CXCR7 staining in mouse prostate epithelial and stromal cells. Picrosirius red staining indicated significantly greater periurethral collagen deposition in the prostates of HFD than LFD‐fed mice. Treatment with the CXCR4 antagonist CXCR4AIII did not affect acquisition of metabolic syndrome but did reduce both urinary voiding dysfunction and periurethral prostate collagen accumulation.ConclusionsThis is the first study to report that obesity‐induced lower urinary tract fibrosis and voiding dysfunction can be repressed by antagonizing the activity of the CXCR4 chemokine receptor in vivo. These data suggest that targeting the CXCL12/CXCR4 signaling pathway may be a clinical option for the prevention or treatment of human male LUTD.
Preparation, characterization and antifungal activity of pyraclostrobin solid nanodispersion by self‐emulsifying technique
Authors: Wang Chunxin , Guo Liang , Yao Junwei , Wang Anqi , Gao Fei , Zhao Xiang , Zeng Zhanghua , Wang Yan , Sun Changjiao , Cui Haixin , Cui Bo 
Published: February 2019

AbstractBACKGROUNDPathogenic fungi are the causal agents of 70–80% of plant diseases. Therefore, it is imperative to explore new and high effective fungicides. Constructing nanoscale fungicides using nanomaterial and nanotechnology has attracted wide attention in recent years.RESULTSIn this research, a pyraclostrobin solid nanodispersion (PSND) was prepared using the self‐emulsifying method. The solid nanodispersion had a mean particle size of 20 nm and a zeta potential of ‐29.3 mV. The solubility and dissolution rate of the PSND increased owing to the decrease in particle size and the actions of the surfactants. The contact angle and retention volumes of the PSND on cucumber and cabbage leaf surfaces were greater than those of the commercial water dispersible granule. In addition, the median lethal concentration against Fusarium oxysporum was 0.7 43 µg mL−1. The toxicity of the nanoparticles was 4.5 times that of the water dispersible granule (WDG). The high fungicidal activity of PSND promoted the production of excess reactive oxygen species (ROS). The activity levels of the antioxidant enzymes containing superoxide dismutase (SOD) and catalase (CAT) decreased in F. oxysporum.CONCLUSIONThe research introduced a new method for preparing insoluble pyraclostrobin solid nanoformulation for fungicides to enhance the fungicidal activity and reduce environmental pollution. © 2019 Society of Chemical Industry
Identification of permethrin and etofenprox cross‐tolerance in Rhipicephalus sanguineus sensu lato (Acari: Ixodidae)
Authors: Tucker Nicholas SG , Kaufman Phillip E , Weeks Emma NI 
Published: February 2019

AbstractBackgroundThe brown dog tick, Rhipicephalus sanguineus sensu lato (Latreille; Acari: Ixodidae), is a peridomestic ectoparasite of dogs and occasionally humans. In some populations, lack of integrated pest management practices and overuse of pesticides has resulted in high levels of resistance to multiple active ingredients. In this study, we established the etofenprox discriminating concentration (DC) and three additional screening concentrations to evaluate resistance status. Using mortality results, cross‐resistance was investigated in brown dog tick populations from five geographically disparate regions, including Asia, Africa, Europe, North America, and the Caribbean, following exposure to the DC for both etofenprox and permethrin separately. Subsequently, using both larval packet tests and molecular methods, etofenprox resistance was investigated.ResultsThe etofenprox DC was set at 0.51%, which allows for the rapid screening of peridomestic brown dog tick populations for resistance to this active ingredient. Cross‐tolerance to two sodium channel‐inhibiting pesticides, permethrin and etofenprox, was observed in one population.ConclusionOur study has provided a single etofenprox concentration that can be used in larval packet tests to determine resistance status in collected peridomestic brown dog ticks, which is particularly important when a single to a few engorged adult ticks are provided for evaluation. Although metabolic resistance is presumed to be the primary resistance mechanism, a sodium channel mutation also confers tolerance to etofenprox at the DC. © 2019 Society of Chemical Industry
Stability of cyflumetofen resistance in Tetranychus cinnabarinus and its correlation with glutathione‐S‐transferase gene expression
Authors: Feng Kaiyang , Yang Yuwei , Wen Xiang , Ou Shiyuan , Zhang Ping , Yu Qian , Zhang Yichao , Shen Guangmao , Xu Zhifeng , Li Jinhang , He Lin 
Published: February 2019

AbstractBACKGROUNDCyflumetofen is an outstanding acaricide with a novel mode of action. Tetranychus cinnabarinus, an important agricultural pest, is notorious for developing resistance to most classes of acaricides rapidly and results in enormous loss for the economy. Our previous study had pointed out glutathione S‐transferase (GSTs) significantly contributed to the cyflumetofen‐resistance formation in T. cinnabarinus, but the more specific mechanism needed to be further investigated.RESULTSThe unstable resistance was observed in cyflumetofen‐resistant strain (CyR)under acaricide‐free condition. The activity of GSTs increased along with the development of resistance. The expressions of 13 GST genes were detected in CyR and susceptible strain (SS), of which six genes were overexpressed in CyR and the TcGSTm02 was selected as the representative for functional study. The expression of TcGSTm02 changed along with the resistant level of CyR with the same trend. Recombinant protein of TcGSTm02 with high activity was successfully obtained by E. coli expression system, whose activity could be inhibited by cyflumetofen (IC50 = 0.23 mM). Recombinant TcGSTm02 could effectively decompose cyflumetofen, and catalyze GS− to conjugate with cyflumetofen.CONCLUSIONAll clues confirmed that GSTs strongly associated with cyflumetofen‐resistance and a representative gene, TcGSTm02, showed function on contributing the evolution of cyflumetofen‐resistance in T. cinnabarinus. © 2019 Society of Chemical Industry
Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry
Authors: Hadavi Darya , de Lange Erik , Jordens Jan , Mengerink Ynze , Cuyckens Filip , Honing Maarten 
Published: February 2019

RationaleThe separation of isomeric compounds with major differences in their physiochemical and pharmacokinetic properties is of particular importance in pharmaceutical R&D. However, the structural assessment and separation of these compounds with current analytical techniques and methods are still a challenge. In this study, we describe strategies to separate the various structural and stereo‐isomers.MethodsThe separation of ten structural and stereo‐isomers was investigated using Trapped and Travelling Wave ion mobility spectrometry (TIMS and TWIMS). Different strategies including adduct ion formation with Na, Li, Ag and Cs as well as fragmentation before and after the ion mobility cell were applied to separate the isomeric compounds.ResultsAll the counter ions (in particular Na) strongly coordinated with the test analytes in all the IMS systems. The highest resolving power was achieved for the sodium and lithium adducts using TIMS‐time‐of‐flight (TOF). However, some separation was attained on a Synapt HDMS system with its unique potential to monitor the ion mobility of the product ions. The elution order of the adduct ions was the same in all instruments, in which, unexpectedly, the para‐substituted isomer of the [M + Na]+ species had the lowest collision cross section followed by the meta‐ and ortho‐isomers.ConclusionsThe formation of adduct ions could facilitate the separation of structural and even stereo‐isomers by generating different molecular conformations. In addition, fragmenting isomers before or after the ion mobility cell is a valuable strategy to separate and also to assess the structures of adducts and different conformers.
Synthesis of PANI/AlOOH composite for Cr(VI) adsorption and reduction from aqueous solutions
Authors: Chen Zhongshan , Wei Benben , Yang Shanye , Li Qian , Liu Lu , Yu Shujun , Wen Tao , Hu Baowei , Chen Jianrong , Wang Xiangke 
Published: February 2019

AbstractIn this study, polyaniline rafted to the surface of AlOOH (PANI/AlOOH) composites were successfully synthesized and applied for chromium (Cr(VI)) adsorption from aqueous solutions. Cr(VI) adsorption isotherms were described by Langmuir model well and the maximum adsorption capacity was 66.77 mg/g at pH=5 and T=298 K. Cr(VI) adsorption was attributed to chemisorption and outer‐sphere surface complexation. The interaction mechanism was further investigated by Fourier transform infrared spectroscopy, transmission electron microscopy‐energy dispersive spectroscopy and X‐ray photoelectron spectroscopy techniques, and the results suggested the partially reduction of Cr(VI) to Cr(III). Cr(VI) removal was mainly related with the electrostatic attraction and chelation of different Cr(VI)/Cr(III) species with protonated nitrogen‐containing functional groups (‐NH+, ‐NH‐) on PANI/AlOOH.
Feasibility of Pristine and Decorated AlN and SiC Nanotubes in Sensing of Noble Gases: A DFT study
Authors: Nemati‐Kande Ebrahim , Abbasi Mahdi , Mohammadi Mohsen Doust 
Published: February 2019

AbstractThe periodic boundary condition density functional theory framework was recruited in order to study the reactivity and electronic sensitivity of aluminium nitride (AlN) and silicon carbide (SiC) nanotubes as well as the gallium‐doped aluminium nitride (AlN(Ga)) and germanium‐doped silicon carbide (SiC(Ge)) nanotubes toward noble gases (NGs). In this respect, the adsorption possibility of the He, Ne, Ar, and Kr NGs onto the exterior surface of AlN, SiC, AlN(Ga) and SiC(Ge) nanotubes in the form of single‐walled armchair (5,5) was comprehensively and comparatively investigated. All possible configurations were considered and optimized at B3LYP/6‐311G (d) level of theory for each unit cells. Moreover, the single point energy calculations were applied on the completed nanotube/gas systems using different functionals including B3LYP, WB97X‐3D, M062X, and CAM−B3LYP in combination with 6–311G (d) and DEF2‐TZVP basis sets. It was found that, there are tiny differences between any possible configurations of gas and nanotube systems, and therefore, the most stable configuration of each system was chosen for further analyses such as density of state, natural bond orbital, and quantum theory of atoms in molecules in order to better understand the intermolecular interaction between NGs and nanotubes. The obtained results indicate that, the Ga‐doped and Ge‐doped nanotubes are more profound in the sensing of NGs compared to the pristine nanotubes.
Synthesis of Functionalised Indoline and Isoquinoline Derivatives through a Silylcarbocyclisation/Desilylation Sequence
Authors: Albano Gianluigi , Morelli Martina , Lissia Margherita , Aronica Laura A. 
Published: February 2019

AbstractA two steps sequence of silylcarbocyclisation‐TBAF promoted desilylation/aryl migration has been applied to the synthesis of indolines and tetrahydroisoquinolines derivatives starting from suitable tosylamides and aryldimethylsilanes. In both cases silylcarbocyclisation reactions determined the formation of the heterocyclic ring together with the insertion of a CO functionality. Under the experimental conditions the carbonyl moiety is reduced to OH quantitatively. Subsequent treatment of silylated indolinols with TBAF generates stereoselectively the corresponding arylmethyl‐tosylindolinols. In the case of tetrahydroisoquinolinols, during the desilylation step, migration of the aryl moiety is followed by spontaneous loss of water thus affording 3,4‐dihydroisoquinolines exclusively.
User allocation‐aware edge cloud placement in mobile edge computing
Authors: Guo Yan , Wang Shangguang , Zhou Ao , Xu Jinliang , Yuan Jie , Hsu Ching‐Hsien 
Published: February 2019

SummaryMobile edge computing is emerging as a novel ubiquitous computing platform to overcome the limit resources of mobile devices and bandwidth bottleneck of the core network in mobile cloud computing. In mobile edge computing, it is a significant issue for cost reduction and QoS improvement to place edge clouds at the edge network as a small data center to serve users. In this paper, we study the edge cloud placement problem, which is to place the edge clouds at the candidate locations and allocate the mobile users to the edge clouds. Specifically, we formulate it as a multiobjective optimization problem with objective to balance the workload between edge clouds and minimize the service communication delay of mobile users. To this end, we propose an approximate approach that adopted the K‐means and mixed‐integer quadratic programming. Furthermore, we conduct experiments based on Shanghai Telecom's base station data set and compare our approach with other representative approaches. The results show that our approach performs better to some extent in terms of workload balance and communication delay and validate the proposed approach.
Typification of four Linnaean names in the genus Juncus (Juncaceae)
Authors: Ferrer‐Gallego P. Pablo 
Published: February 2019

AbstractThe lectotypification of four Linnaean names in the genus Juncus: J. articulatus, J. inflexus, J. pilosus (≡ Luzula pilosa) and J. stygius is discussed. The designation of the nomenclatural types is based on the consultation of Linnaeus's original material and the literature cited in the respective protologues. The names are lectotypified using specimens from LINN and L (Adriaan van Royen Herbarium), and a Morison illustration for the name J. inflexus. Furthermore, an epitype is designated for J. inflexus due to ambiguity in the interpretation of the lectotype.
On the priority of Orthotrichum cylindrocarpum over O. coulteri and Lesquereux's early vindication of an autonomous American bryology
Authors: Medina Rafael , Lara Francisco , Goffinet Bernard , Garilleti Ricardo , Mazimpaka Vicente 
Published: February 2019

AbstractIn a recent revision of the Orthotrichum tenellum complex, the authors erroneously concluded that the name O. coulteri predated the supposed synonym O. cylindrocarpum. This confusion was due to incongruent publication dates reported in the literature and lack of evidence of effective publication of the latter. Here, we demonstrate that the name O. cylindrocarpum was indeed published a few months before O. coulteri based on correspondence by the authorities and dated reprints. The almost simultaneous publication of both names occurred during a period in which some early American bryologists advocated that the discovery of new species from North America should be reported by them and not by their European colleagues.
Students' self‐efficacy for science in different school systems
Authors: Dorfman Bat‐Shahar , Fortus David 
Published: February 2019

AbstractThe important role of self‐efficacy (SE) in students' motivation, engagement, persistence, and academic achievements has been reconfirmed by ample research, both in general and for STEM disciplines. As most studies focused on traditional school systems, additional research is needed on how science SE develops in different educational environments, which was the goal of this study. Data were collected from 1979 students in Grades 5–9 from 19 traditional, Waldorf, and democratic schools in Israel. Students completed a questionnaire that assessed their science self‐efficacy (SSE), general and academic self‐efficacy (GASE), and the sources of their SSE: teachers', parents', and peers' social persuasions, vicarious experiences and mastery experiences. Results revealed that SSE and GASE differed in their levels and in the way they changed with grade. These differences, and variations in the roles of the various sources of SSE, appeared to be influenced by the schools' cultures and curricula. Quantitative results are accompanied by verbal illustrative examples from interviews with students and teachers.
TGF‐β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells
Authors: Tian Minmin , Chang Xuhong , Zhang Qiong , Li Chengyun , Li Sheng , Sun Yingbiao 
Published: February 2019

AbstractNickel oxide nanoparticles (Nano NiO) could induce pulmonary fibrosis, however, the mechanisms are still unknown. The aim of the present study was to explore the roles of transforming growth factor‐β1 (TGF‐β1), mitogen‐activated protein kinase (MAPK) pathway and MMPs/TIMPs balance in Nano NiO‐induced pulmonary fibrosis. For that purpose, we first established Nano NiO‐induced human lung adenocarcinoma epithelial cells (A549 cells) model of collagen excessive formation through detecting the levels of hydroxyproline (Hyp) and type I collagen (Col‐I). Then the protein levels of TGF‐β1, MAPKs, and MMPs/TIMPs were assessed by Western blot. The results showed that Nano NiO resulted in the increased contents of Hyp, Col‐I, and TGF‐β1, the MAPK pathway activation and MMPs/TIMPs imbalance with a dose‐dependent manner. In addition, to investigate whether TGF‐β1 mediated MAPK signaling pathway, A549 cells were treated by 100 μg/mL Nano NiO combined with TGF‐β1, p38 MAPK, and ERK1/2 inhibitors (10 μM SB431542, 10 μM SB203580, and 10 μM U0126), respectively. We found that MAPK signal pathway was suppressed by TGF‐β1 inhibitor. Meanwhile, the increased contents of Hyp and Col‐I, and MMPs/TIMPs imbalance were alleviated by the p38 MAPK and ERK1/2 inhibitors, respectively. These findings indicated that the MAPK pathway and MMPs/TIMPs imbalance were involved in collagen excessive formation induced by Nano NiO.