bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between prenatal and postnatal conditions and accelerated postnatal growth. Impact on the rigidity of the arterial wall and obesity in childhood
Authors: Mora-Urda A. I. , Acevedo P. , Montero López M. P. 
Published: July 2019

AbstractRestricted growthin uteroand accelerated postnatal growth (APG) in the postnatal period have been associated with the development of overweight, obesity and an increased cardiovascular risk in childhood. The objectives of this study were to evaluate the influence of prenatal and perinatal conditions on APG and to evaluate the influence of this APG on different cardiovascular risk factors such as body mass index (BMI), body fat mass index (FMI), blood pressure (BP) and arterial wall stiffness [carotid to femoral pulse wave velocity (cf-PWV)]. All measurements were performed in 355 children (185 boys and 170 girls; 8–11 years). Data on mother weight before and during pregnancy, gestational age (weeks), birth weight (g) and breastfeeding of children were obtained through interviews with families. Children who presented APG were born of mothers with lower BMIs before pregnancy and who gained less weight during the second trimester of pregnancy. They also have a lower gestational age and birth weight, a shorter duration of breastfeeding and a longer duration of artificial feeding (AF). Later in childhood, they had higher values of cf-PWV, BMI, FMI and higher prevalence of hypertension. Low maternal gestational weight gain, inadequate fetal development (low birth weight, shorter gestational age) and reduced breastfeeding duration favor APG. Infants with such APG had higher values of cf-PWV, BP, BMI and FMI later in childhood, along with a higher risk of hypertension and obesity. The interaction between APG and a longer duration of AF had a negative effect on cf-PWV (arterial stiffness) and FMI.
Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
Authors: Li Wenna , Ma Lin , Shen Xiaolin , Wang Jia , Feng Qi , Liu Lexuan , Zheng Guojun , Yan Yajun , Sun Xinxiao , Yuan Qipeng 
Published: July 2019

AbstractVarious biosynthetic pathways have been designed to explore sustainable production of glutarate, an attractive C5 building block of polyesters and polyamides. However, its efficient production has not been achieved inEscherichia coli. Here, we useE. colinative lysine catabolic machinery for glutarate biosynthesis. This endogenous genes-only design can generate strong metabolic driving force to maximize carbon flux toward glutarate biosynthesis by replenishing glutamate and NAD(P)H for lysine biosynthesis, releasing lysine feedback inhibition, and boosting oxaloacetate supply. We use native transporters to overcome extracellular accumulation of cadaverine and 5-aminovalerate. With these efforts, both high titer (54.5 g L−1) and high yield (0.54 mol mol−1glucose) of glutarate production are achieved under fed-batch conditions. This work demonstrates the power of redirecting carbon flux and the role of transporters to decrease intermediate accumulation.
Spiculogenesis and biomineralization in early sponge animals
Authors: Tang Qing , Wan Bin , Yuan Xunlai , Muscente A. D. , Xiao Shuhai 
Published: July 2019

AbstractMost sponges have biomineralized spicules. Molecular clocks indicate sponge classes diverged in the Cryogenian, but the oldest spicules are Cambrian in age. Therefore, sponges either evolved spiculogenesis long after their divergences or Precambrian spicules were not amenable to fossilization. The former hypothesis predicts independent origins of spicules among sponge classes and presence of transitional forms with weakly biomineralized spicules, but this prediction has not been tested using paleontological data. Here, we report an early Cambrian sponge that, like several other early Paleozoic sponges, had weakly biomineralized and hexactine-based siliceous spicules with large axial filaments and high organic proportions. This material, along with Ediacaran microfossils containing putative non-biomineralized axial filaments, suggests that Precambrian sponges may have had weakly biomineralized spicules or lacked them altogether, hence their poor record. This work provides a new search image for Precambrian sponge fossils, which are critical to resolving the origin of sponge spiculogenesis and biomineralization.
How conflict shapes evolution in poeciliid fishes
Authors: Furness Andrew I. , Pollux Bart J. A. , Meredith Robert W. , Springer Mark S. , Reznick David N. 
Published: July 2019

AbstractIn live-bearing animal lineages, the evolution of the placenta is predicted to create an arena for genomic conflict during pregnancy, drive patterns of male sexual selection, and increase the rate of speciation. Here we test these predictions of the viviparity driven conflict hypothesis (VDCH) in live-bearing poecilid fishes, a group showing multiple independent origins of placentation and extreme variation in male sexually selected traits. As predicted, male sexually selected traits are only gained in lineages that lack placentas; while there is little or no influence of male traits on the evolution of placentas. Both results are consistent with the mode of female provisioning governing the evolution of male attributes. Moreover, it is the presence of male sexually selected traits (pre-copulatory), rather than placentation (post-copulatory), that are associated with higher rates of speciation. These results highlight a causal interaction between female reproductive mode, male sexual selection and the rate of speciation, suggesting a role for conflict in shaping diverse aspects of organismal biology.
Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli
Authors: Zampieri Mattia , Hörl Manuel , Hotz Florian , Müller Nicola F. , Sauer Uwe 
Published: July 2019

AbstractHow microbes dynamically coordinate uptake and simultaneous utilization of nutrients in complex nutritional ecosystems is still an open question. Here, we develop a constraint-based modeling approach that exploits non-targeted exo-metabolomics data to unravel adaptive decision-making processes in dynamic nutritional environments. We thereby investigate metabolic adaptation of Escherichia coli to continuously changing conditions during batch growth in complex medium. Unexpectedly, model-based analysis of time resolved exo-metabolome data revealed that fastest growth coincides with preferred catabolism of amino acids, which, in turn, reduces glucose uptake and increases acetate overflow. We show that high intracellular levels of the amino acid degradation metabolites pyruvate and oxaloacetate can directly inhibit the phosphotransferase system (PTS), and reveal their functional role in mediating regulatory decisions for uptake and catabolism of alternative carbon sources. Overall, the proposed methodology expands the spectrum of possible applications of flux balance analysis to decipher metabolic adaptation mechanisms in naturally occurring habitats and diverse organisms.
Ab initio vibrational free energies including anharmonicity for multicomponent alloys
Authors: Grabowski Blazej , Ikeda Yuji , Srinivasan Prashanth , Körmann Fritz , Freysoldt Christoph , Duff Andrew Ian , Shapeev Alexander , Neugebauer Jörg 
Published: July 2019

AbstractThe unique and unanticipated properties of multiple principal component alloys have reinvigorated the field of alloy design and drawn strong interest across scientific disciplines. The vast compositional parameter space makes these alloys a unique area of exploration by means of computational design. However, as of now a method to compute efficiently, yet with high accuracy the thermodynamic properties of such alloys has been missing. One of the underlying reasons is the lack of accurate and efficient approaches to compute vibrational free energies—including anharmonicity—for these chemically complex multicomponent alloys. In this work, a density-functional-theory based approach to overcome this issue is developed based on a combination of thermodynamic integration and a machine-learning potential. We demonstrate the performance of the approach by computing the anharmonic free energy of the prototypical five-component VNbMoTaW refractory high entropy alloy.
Modeling the effect of insoluble corrosion products on pitting corrosion kinetics of metals
Authors: Ansari Talha Qasim , Luo Jing-Li , Shi San-Qiang 
Published: July 2019

AbstractMost metals naturally corrode in an engineering environment and form corrosion products. The corrosion products can be either soluble or insoluble in the aqueous solution. The insoluble corrosion products (ICP) could have profound effects on the corrosion kinetics of the concerned metal. In this study, a multi-phase-field formulation is proposed to investigate the effects of ICP formation on pitting corrosion kinetics. The Gibbs free energy of the metal-electrolyte-insoluble corrosion product system consists of chemical, gradient, and electromigration free energy. The model is validated with experimental results and several representative cases are presented, including the effect of the porosity of ICP, under-deposit corrosion, corrosion of sensitized alloys, and microstructure-dependent pitting corrosion. It is observed that corrosion rate and pit morphology significantly depend on ICP and its porosity for the same applied potential.
Gastric dysmotility in Parkinson's disease is not caused by alterations of the gastric pacemaker cells
Authors: Heimrich Konstantin G. , Jacob Veit Y. P. , Schaller Denise , Stallmach Andreas , Witte Otto W. , Prell Tino 
Published: July 2019

AbstractThe enteric nervous system is involved in the pathology of Parkinson´s disease and patients frequently have symptoms related to delayed gastric emptying. However, the pathophysiology of gastric dysmotility is yet not well understood. The objective of this study was to assess interdigestive gastric motility in Parkinson´s disease. Using an electromagnetic capsule system, the dominant gastric contraction frequency (primary outcome measure) and the gastric transit time were assessed in 16 patients with Parkinson´s disease and 15 young healthy controls after a fasting period of 8 h. Motor and non-motor symptoms were assessed using the Movement Disorder Society Unified Parkinson´s Disease Rating Scale III (MDS-UPDRS III), the Non-Motor Symptoms Questionnaire (NMS-Quest), and Hoehn & Yahr staging. The Gastroparesis Cardinal Symptom Index was used to record symptoms related to delayed gastric emptying. In healthy controls and patients with Parkinson's disease, the dominant contraction frequency was 3.0 cpm indicating normal function of interstitial cells of Cajal. In patients with Parkinson's disease, the gastric transit time was longer than in younger controls (56 vs. 21 min). The dominant contraction frequency and gastric transit time did not correlate with age, disease duration, Hoehn & Yahr stage, levodopa equivalent daily dose, MDS-UPDRS III, NMS-Quest, and Gastroparesis Cardinal Symptom Index. Changes of gastric motility in Parkinson´s disease are not caused by functional deficits of the gastric pacemaker cells, the interstitial cells of Cajal. Therefore, gastroparesis in Parkinson's disease can be attributed to disturbances in neurohumoral signals via the vagus nerve and myenteric plexus.
Ghost imaging using entanglement-swapped photons
Authors: Bornman Nicholas , Agnew Megan , Zhu Feng , Vallés Adam , Forbes Andrew , Leach Jonathan 
Published: July 2019

AbstractTraditional ghost imaging requires correlated but spatially separated photons and has been observed in many physical situations, spanning both the quantum and classical regimes. Here we observe ghost imaging in a new system—a system based on entanglement swapping, the key feature of a quantum network. We detail how the exact form of quantum interference between independent photons dictates the precise nature of the ghost imaging, for example, for an anti-symmetric projection, the recorded image is the contrast-reversed version of the object—where the object is bright, the image is dark, and vice versa. The results highlight the importance of state projection in this ghost-imaging process and provide a pathway for the teleportation of two-dimensional spatial states across a quantum network. Our results also indicate that ghost images with new image properties could be achieved in conventional settings through a variety of new signal processing procedures.
Sleep, napping and alertness during an overwintering mission at Belgrano II Argentine Antarctic station
Authors: Folgueira Agustín , Simonelli Guido , Plano Santiago , Tortello Camila , Cuiuli Juan Manuel , Blanchard Abel , Patagua Alejandro , Brager Allison J. , Capaldi Vincent F. , Aubert André E. , Barbarito Marta , Golombek Diego A. , Vigo Daniel E. 
Published: July 2019

AbstractDuring Antarctic isolation personnel are exposed to extreme photoperiods. A frequent observation is a sleep onset phase delay during winter. It is not known if, as a result, daytime sleeping in the form of naps increases. We sought to assess sleep patterns - with focus on daytime sleeping - and alertness in a Latin American crew overwintering in Argentine Antarctic station Belgrano II. Measurements were collected in 13 males during March, May, July, September and November, and included actigraphy and psychomotor vigilance tasks. Sleep duration significantly decreased during winter. A total of eight participants took at least one weekly nap across all measurement points. During winter, the nap onset was delayed, its duration increased and its efficiency improved. We observed a significant effect of seasonality in the association of evening alertness with sleep onset. Our results replicate previous findings regarding sleep during overwintering in Antarctica, adding the description of the role of napping and the report of a possible modulatory effect of seasonality in the relation between sleep and alertness. Napping should be considered as an important factor in the scheduling of activities of multicultural crews that participate in Antarctica.
Association of tagSNPs at lncRNA MALAT-1 with HCC Susceptibility in a Southern Chinese Population
Authors: Ji Xiaohui , Zhang Junguo , Liu Li , Lin Ziqiang , Pi Lucheng , Lin Zhifeng , Tian Nana , Lin Xinqi , Chen Sidong , Yu Xinfa , Gao Yanhui 
Published: July 2019

AbstractAs a long non-coding RNA (lncRNA) and a transcriptional regulator, Metastasis associated lung adenocarcioma transcript-1 (MALAT-1) has been reported to be associated with proliferation and metastasis of hepatocellular carcinoma (HCC). However, the effects of MALAT-1 single nucleotide polymorphisms (SNPs) on HCC remains poorly understood. This study, including 624 HCC cases and 618 controls, aimed to explore the potential associations between three common tagSNPs at MALAT-1 and HCC risk in a Southern Chinese population. No significant associations were observed between the three tagSNPs and HCC risk under any genetic models after adjusting for potential confounders. Additionally, there were no any significant associations in the stratified analysis, combined effect analysis, and multifactor dimensionality reduction (MDR) analysis. Unification analysis of mediation and interaction on HCC risk further showed that four decomposition of total effects ((controlled direct effect (CDE), the reference interaction effect (INTref), the mediated interaction effect (INTmed), or the pure indirect effect (PIE)) were also not significant. Neither was the association between the MALAT-1 SNPs and progression factors of HCC, including TNM staging, metastasis, and cancer embolus; Overall, this study suggested that tagSNPs rs11227209, rs619586, and rs3200401 at MALAT-1 were not significantly associated with HCC susceptibility. Nevertheless, large population-based studies are warranted to further explore the role of MALAT-1 SNPs in HCC incidence and development.
Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study
Authors: Danquah Ina , Addo Juliet , Boateng Daniel , Klipstein-Grobusch Kerstin , Meeks Karlijn , Galbete Cecilia , Beune Erik , Bahendeka Silver , Spranger Joachim , Mockenhaupt Frank P. , Stronks Karien , Agyemang Charles , Schulze Matthias B. , Smeeth Liam 
Published: July 2019

AbstractEarly-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist circumference and type 2 diabetes among Ghanaian adults. In the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study, we calculated associations (adjusted for demographics and lifestyle) of parental education and anthropometric markers of childhood nutrition [leg length, leg length-to-height ratio (LHR)] with waist circumference and type 2 diabetes, respectively. Among 5,575 participants (mean age: 46.2 years; 62% female), lower education of either parent (vs. higher) was consistently associated with higher waist circumference (∆: 1.6–3.4 cm). Lower father’s education tended to increase the odds of type 2 diabetes by 50% in women (95% confidence interval (CI): 1.0, 2.4). Reduced leg length and LHR were associated with higher waist circumference. But only in men, leg length was inversely related to type 2 diabetes (OR per 1 standard deviation decrease: 1.1; 95% CI: 1.0, 1.3). In this study, markers of poor childhood SES and early-life nutritional status relate to abdominal obesity in men and women and to type 2 diabetes in men. Thus, prevention efforts should start in early childhood.
3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy
Authors: França Cristiane Miranda , Riggers Rachelle , Muschler John L. , Widbiller Matthias , Lococo Peter Manning , Diogenes Anibal , Bertassoni Luiz Eduardo 
Published: July 2019

AbstractDirect visualization of the spatial relationships of the dental pulp tissue at the whole-organ has remained challenging. CLARITY (Clear Lipid-exchanged Acrylamide Tissue hYdrogel) is a tissue clearing method that has enabled successful 3-dimensional (3D) imaging of intact tissues with high-resolution and preserved anatomic structures. We used CLARITY to study the whole human dental pulp with emphasis on the neurovascular components. Dental pulps from sound teeth were CLARITY-cleared, immunostained for PGP9.5 and CD31, as markers for peripheral neurons and blood vessels, respectively, and imaged with light sheet microscopy. Visualization of the whole dental pulp innervation and vasculature was achieved. Innervation comprised 40% of the dental pulp volume and the vasculature another 40%. Marked innervation morphological differences between uni- and multiradicular teeth were found, also distinct neurovascular interplays. Quantification of the neural and vascular structures distribution, diameter and area showed that blood vessels in the capillary size range was twice as high as that of nerve fibers. In conclusion whole CLARITY-cleared dental pulp samples revealed 3D-morphological neurovascular interactions that could not be visualized with standard microscopy. This represents an outstanding tool to study the molecular and structural intricacies of whole dental tissues in the context of disease and treatment methods.
Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7
Authors: Morla Sudhir , Kumar Ajay , Kumar Sachin 
Published: July 2019

AbstractCancer cell metastasis and its dissemination are most enigmatic and challenging aspects in the development of its therapeutics. Newcastle disease virus (NDV) is a well-studied avian paramyxovirus frequently isolated from birds and rarely from mammals. Since the first report of its oncolytic property, many NDV strains were studied for its effect in various cancer cells. In the present study, NDV strain Bareilly was characterized for its apoptotic potential and migration inhibition in human oral cancer cells. The NDV mediated apoptosis was confirmed by flow cytometry, DNA laddering, and immunoblotting. Moreover, NDV decreased the mitochondrial membrane potential suggesting an intrinsic pathway of apoptosis in oral cancer cells. NDV infection in oral cancer cells results in migration inhibition by a reduction in levels of MMP-7. MMP-7 is one of the key target genes of β-catenin. While overexpression of MMP-7 reversed the inhibitory effect of NDV mediated migration suggested its possible involvement. Wnt/β-catenin is an essential pathway for cell growth, differentiation, and metastasis. The involvement of the Wnt/β-catenin pathway in NDV infection has never been reported. Our results showed that NDV dysregulates Wnt/β-catenin by down-regulation of p-Akt and p-GSK3β leading to degradation of β-catenin. Furthermore, NDV infection leads to a reduction in cytoplasmic and nuclear levels of β-catenin. The study will provide us with a better insight into the molecular mechanism of NDV mediated oncolysis and the key cellular partners involved in the process.
Clean interface without any intermixed state between ultra-thin P3 polymer and CH3NH3PbI3 hybrid perovskite thin film
Authors: Jung Min-Cherl , Matsuyama Asuka , Kobori Sora , Maeng Inhee , Lee Young Mi , Song Myungkwan , Jin Sung-Ho , Nakamura Masakazu 
Published: July 2019

AbstractHole transport layers (HTL) are crucial materials to improve the power conversion efficiency in organohalide hybrid perovskite-based solar-cell applications. Two important physical properties are required in HTL materials: good hole mobility and air-protection. After HTL solution-based deposition, an intermixed chemical state at the interface between HTL and hybrid perovskite is key to confirming the physical property of HTL. We performed high-resolution x-ray photoelectron spectroscopy to investigate the chemical states at the interface between an ultra-thin P3 polymer and CH3NH3PbI3 hybrid perovskite thin film. At the interface, we found no apparent intermixed chemical state. Furthermore, we confirmed that the P3 HTL with the ultra-thin layer (7 nm) protected the hybrid perovskite material against air-exposure for 2 weeks.
Strong links promote the emergence of cooperative elites
Authors: Gallo Edoardo , Riyanto Yohanes E. , Teh Tat-How , Roy Nilanjan 
Published: July 2019

AbstractThe maintenance of cooperative behavior is fundamental for the prosperity of human societies. Empirical studies show that high cooperation is frequently associated with the presence of strong social ties, but they are silent on whether a causal mechanism exists, how it operates, and what features of the social environment are conducive to its emergence. Here we show experimentally that strong ties increase cooperation and welfare by enabling the emergence of a close-knit and strongly bound cooperative elite. Crucially, this cooperative elite is more prevalent in social environments characterized by a large payoff difference between weak and strong ties, and no gradation in the process of strengthening a tie. These features allow cooperative individuals to adopt an all or nothing strategy to tie strengthening based on the well-known mechanism of direct reciprocity: participants become very selective by forming strong ties only with other cooperative individuals and severing ties with everyone else. Once formed, these strong ties are persistent and enhance cooperation. A dichotomous society emerges with cooperators prospering in a close-knit, strongly bound elite, and defectors earning low payoffs in a weakly connected periphery. Methodologically, our set-up provides a framework to investigate the role of the strength of ties in an experimental setting.