bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut Microbiota–Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression
Authors: Yao Huihui , Xu Jiancheng , Zhou Aina , Shen Danyang , Dong Qiuchen , Yang Xiaodong , Li Mengyu , Mi Xiuwei , Lu Yang , Zhong Runze , Shi Xinyu , Tai Qingliang , Chen Guoliang , Shi Bo , Sun Liang , Zhou Diyuan , Yao Yizhou , He Songbing 
Published: December 2024

Abstract
Recent evidence indicates that a high-fat diet can promote tumor development, especially colorectal cancer, by influencing the microbiota. Regulatory circular RNA (circRNA) plays an important role in modulating host–microbe interactions; however, the specific mechanisms by which circRNAs influence cancer progression by regulating these interactions remain unclear. Here, we report that consumption of a high-fat diet modulates the microbiota by specifically upregulating the expression of the noncoding RNA hsa_circ_0126925 (herein, referred to as circ_0126925) in colorectal cancer. Acting as a scaffold, circ_0126925 hinders the recruitment of the E3 ubiquitin ligase tripartite motif-containing protein 21 (TRIM21) to branched-chain amino acid transaminase 2 (BCAT2), leading to reduced degradation of BCAT2. This reduction in targeted degradation of BCAT2 can protect tumors from limited branched-chain amino acid (BCAA) interference by improving the metabolism of BCAAs in colorectal cancer. Taken together, these data demonstrate that circ_0126925 plays a critical role in promoting the progression of colorectal cancer by maintaining BCAA metabolism and provide insight into the functions and crosstalk of circ_0126925 in host–microbe interactions in colorectal cancer.
Implications: This study preliminarily confirms that circRNAs do indeed respond to microbiota/microbial metabolites, providing further evidence for the potential development of circRNAs as diagnostic tools and/or therapeutic agents to alleviate microbiome-related pathology in humans.
Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Authors: Buri Michelle C. , Shoeb Mohamed R. , Bykov Aleksandr , Repiscak Peter , Baik Hayeon , Dupanovic Alma , David Faith O. , Kovacic Boris , Hall-Glenn Faith , Dopa Sara , Urbanus Jos , Sippl Lisa , Stofner Susanne , Emminger Dominik , Cosgrove Jason , Schinnerl Dagmar , Poetsch Anna R. , Lehner Manfred , Koenig Xaver , Perié Leïla , Schumacher Ton N. , Gotthardt Dagmar , Halbritter Florian , Putz Eva M. 
Published: December 2024

Abstract
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumor growth and is divided into three phases: elimination, equilibrium, and escape. The role of NK cells has mainly been attributed to the elimination phase. Here, we show that NK cells play a role in all three phases of cancer immunoediting. Extended co-culturing of DNA-barcoded mouse BCR/ABLp185+ B-cell acute lymphoblastic leukemia (B-ALL) cells with NK cells allowed for a quantitative measure of NK cell–mediated immunoediting. Although most tumor cell clones were efficiently eliminated by NK cells, a certain fraction of tumor cells harbored an intrinsic primary resistance. Furthermore, DNA barcoding revealed tumor cell clones with secondary resistance, which stochastically acquired resistance to NK cells. NK cell–mediated cytotoxicity put a selective pressure on B-ALL cells, which led to an outgrowth of primary and secondary resistant tumor cell clones, which were characterized by an IFNγ signature. Besides well-known regulators of immune evasion, our analysis of NK cell–resistant tumor cells revealed the upregulation of genes, including lymphocyte antigen 6 complex, locus A (Ly6a), which we found to promote leukemic cell resistance to NK cells. Translation of our findings to the human system showed that high expression of LY6E on tumor cells impaired their physical interaction with NK cells and led to worse prognosis in patients with leukemia. Our results demonstrate that tumor cells are actively edited by NK cells during the equilibrium phase and use different avenues to escape NK cell–mediated eradication.
Effect of cell-free culture filtrates of Purpureocillium lilacinum on inactivity, mortality and reproduction of Aphelenchoides besseyi
Authors: Philadelphi Sophia Moracchioli , Pascholati Sérgio F. , Holz Sabrina , de Souza Victor H.M. 
Published: December 2024

Summary
The soybean, Glycine max, is a major agricultural commodity in Brazil, significantly affected by a wide range of plant-parasitic nematodes, notably Aphelenchoides besseyi. With no resistant cultivars available or registered nematicides, management options for this nematode are limited. This study investigated the effects of cell-free culture filtrates from three Purpureocillium lilacinum isolates (CCT 7766, UEL PAE 10 and PLI) on A. besseyi inactivity, mortality and reproduction in vitro compared to a water control. Nematodes were treated with P. lilacinum culture filtrates, and their activity was quantified after 24, 48 and 72 h. Mortality was assessed by counting inactive individuals after the addition of a Na2CO3 solution. Reproduction effects were tested by treating nematodes with filtrates and culturing them on Fusarium sp. plates for 21 days. After this period, nematodes that migrated to the lids of the plates were counted under a microscope (100× magnification) to determine the final nematode population. Results indicated 100% reduction in active nematodes across all isolates after 24 h. Culture filtrates exhibited low nematicidal effects, with nematode motility resuming after Na2CO3 exposure. Interestingly, individuals exposed to the CCT 7766 culture filtrate displayed a distinctive phenotype, characterised by impaired motility and partial body paralysis, even after the recovery period. Regarding reproduction, PLI strain significantly reduced the final nematode population – and consequently the reproduction factor – when compared to the water control treatment. This study validates a suitable methodology for effectively assessing the mortality of A. besseyi in vitro, and suggests P. lilacinum as a promising biocontrol agent, although further research is needed to explore its efficacy in agricultural settings.
Collective Sufism in the Maghrib al-Aqṣā: the Mājariyyūn of Safi and the Founding of the Rakb al-Ḥujjāj
Authors: El Hour Rachid , Vázquez Hernández Virginia 
Published: December 2024

Abstract
This paper studies one of the most emblematic Maghrebi ribāṭs (Ṣufī outposts, residences, and centers guidance) in the Islamic West as a prime manifestation of collective Sufism, both in terms of its seminal role in history, at least up until the Portuguese invasion of the Moroccan coasts in the fifteenth century, as well as the importance of its founder, Abū Muḥammad Ṣāliḥ (d. 631/1233), who also founded the ṭarīqa al-mājariyya, a dominant force in the social and religious life of the Maghrib al-Aqṣā. One of this walī Allāh’s most significant acts of renewal was the revival and consolidation of the Hajj amid a period characterized by an acute lack of security in the Mediterranean due to the Crusades, thus countering the legal opinion of a range of revered Maghrebi scholars, including Ibn Rushd al-Jadd, the chief qāḍī of Almoravid Córdoba.
This study focuses on two central aspects: on the one hand, the Ribāṭ of Safi and its historical evolution, and, on the other, the role of the Mājariyyūn in organizing and institutionalizing the Hajj under the Marinids, which makes Safi a unique case in the history of the ribāṭs of the Maghrib al-Aqṣā. Regarding the second aspect dealt with in the study, we would like to clarify that our aim is not to analyze Maghrebi travel literature but rather to highlight the singular role played by the Mājariyyūn in reinstating journeys of pilgrimage to the Islamic holy lands.
From Molecules to Droplets: The Fog and Aerosol Interaction Research Italy (FAIRARI) 2021/22 Campaign
Authors: Neuberger Almuth , Decesari Stefano , Aktypis Andreas , Andersen Hendrik , Baumgardner Darrel , Bianchi Federico , Busetto Maurizio , Cai Jing , Cermak Jan , Dipu Sudhakar , Ekman Annica , Fuzzi Sandro , Gramlich Yvette , Haslett Sophie L. , Heikkinen Liine , Joutsensaari Jorma , Kaltsonoudis Christos , Kangasluoma Juha , Krejci Radovan , Lupi Angelo , Marinoni Angela , Matrali Angeliki , Mattsson Fredrik , Mohr Claudia , Nenes Athanasios , Paglione Marco , Pandis Spyros N. , Patel Anil , Riipinen Ilona , Rinaldi Matteo , Steimer Sarah S. , Stolzenburg Dominik , Sulo Juha , Vasilakopoulou Christina N. , Zieger Paul 
Published: December 2024

Abstract
The Italian Po Valley is one of the most polluted regions in Europe. During winter, meteorological conditions favor long and dense fogs, which strongly affect visibility and human health. In spring, the frequency of nighttime fogs reduces while daytime new particle formation events become more common. This transition is likely caused by a reduction in particulate matter (PM2.5), leading to a decrease in the relevant condensation sink. The physics and chemistry of fog and aerosol have been studied at the San Pietro Capofiume site since the 1980s, but the detailed processes driving the observed trends are not fully understood. Hence, during winter and spring 2021/22, the Fog and Aerosol Interaction Research Italy (FAIRARI) campaign was carried out, using a wide spectrum of approaches, including in situ measurements, outdoor chamber experiments, and remote sensing. Atmospheric constituents and their properties were measured ranging from gas molecules and molecular clusters to fog droplets. One unique aspect of this study is the direct measurement of the aerosol composition inside and outside of fog, showing a slightly greater dominance of organic compounds in the interstitial compared to the droplet phase. Satellite observations of fog provided a spatial context and agreed well with in situ measurements of droplet size. They were complemented with in situ chamber experiments, providing insights into oxidative processes and revealing a large secondary organic aerosol-forming potential of ambient air upon chemical aging. The oxidative potential of aerosol and fog water inferred the impact of aerosol–fog interactions on particle toxicity.
Harnessing UAS and high-resolution satellite imagery to better characterize wind damage and understand tornado behavior
Authors: Wagner Melissa , Coniglio Michael , Rasmussen Erik , Satrio Martin , Bodine David , Candela Dominic , Kennedy Doug , Tirone Elizabeth 
Published: December 2024

Abstract
The severe storms research community continues to strive toward measuring and quantifying wind speeds near the ground in tornadoes as a component of meeting society’s needs of protecting life and property. Current methods to measure and characterize tornadoes and their wind speeds all have limitations, particularly when only vegetation and rural areas are impacted. To address these problems, the National Severe Storms Laboratory (NSSL) and the Cooperative Institute for Severe and High-Impact Weather for Research and Operations (CIWRO) employed Uncrewed Aerial Systems (UAS) technologies and specialized satellites to assess storm damage through finescale mapping of wind damage immediately following storm events. From 2021-2023, NSSL-CIWRO led 48 UAS-based damage assessments spanning the northern High Plains to the Gulf Coast areas. The goals of this work were to improve our knowledge of tornado dynamics as a function of land cover and topography and to better understand mechanisms of wind damage production in convective storms. In parallel, NSSL-CIWRO developed workflows to facilitate rapid sharing of UAS and satellite imagery to National Weather Service Weather Forecast Offices (NWS WFOs) and the Federal Emergency Management Agency (FEMA). Operationally, NSSL UAS imagery and derived products have aided traditional ground- and satellite-based surveys and have provided important clues on tornado intensity by detailing damage to vegetation in inaccessible areas. UAS and high-resolution satellite imagery may become a routine and key component to understand tornado and severe weather behavior through analysis of specialized field observations.
Airborne Soil-Derived Dust Hazards in Aviation
Authors: Scherllin-Pirscher Barbara , Nickovic Slobodan , Votsis Athanasios , Cvetkovic Bojan , Amiridis Vassilis , Bolic Tatjana , Brenot Hugues , Brock Greg , Clarkson Rory J. , Durant Adam , Hirtl Marcus , Lekas Theodore I. , Mona Lucia , Nasser Hisham , Ryder Claire L. , Ryuzaki Jun , Suárez-Molina David , Vukovic Vimic Ana , Basart Sara 
Published: December 2024

Abstract
Airborne mineral dust poses a safety challenge for aviation. Several fatal accidents have happened in dust-laden air due to reduced visibility, strong gusty winds, and wind shear. Dust-induced icing also contributed at least to two fatal accidents. Furthermore, atmospheric dust has long- and short-term effects on aircraft operating conditions due to corrosion and abrasion on the aircraft surfaces and molten ingress deterioration of engine hot section components. The combined impact can increase operating and maintenance costs and increase the overall cost of ownership. While the scientific community has started preparing and providing products based on atmospheric dust modeling and observation, there are still important data and information gaps in the fundamental science. These include (i) insufficient data which could be used to better understand the effects of dust on aircraft as well as on ground systems and operations (e.g., four-dimensional information of dust mineralogy, cost–benefit analysis of the impact of dust on aviation along flight routes), (ii) the identification of airborne dust monitoring and modeling products and services that could enable the flow of relevant information in commercial aviation and in decision-making workflows, and (iii) the underdeveloped, unclear, or absent role of dust hazards in regulations and operational procedures as well as in the training, skill set, and knowledge base of pilots. This review is aimed at both academic and aviation stakeholders and presents the current state-of-the-art knowledge at the intersection of dust hazards, aviation safety, and impacts on flight operations and aircraft maintenance.
Diagnosing the Factors That Contribute to the Intermodel Spread of Climate Feedback in CMIP6
Authors: Wang Chenggong , Yang Wenchang , Vecchi Gabriel , Zhang Bosong , Soden Brian J. , Chan Duo 
Published: December 2024

Abstract
The global surface temperature climate feedback parameter λ varies significantly across climate models, and its real-world value remains uncertain. Studies have found that the sea surface temperature (SST) response pattern and atmospheric model physics can each affect the climate feedback parameter in historical and idealized warming simulations. In this study, we design and analyze a series of the targeted atmospheric global climate model (AGCM) experiments to quantify how much the SST (both the warming pattern and the base climatology) and atmospheric model physics contributes to the intermodel spread of the climate feedback parameter and cloud feedback in phase 6 of the Coupled Model Intercomparison Project (CMIP6). We use three AGCMs, HiRAM, AM2.5, and AM4, developed in the Geophysical Fluid Dynamics Laboratory (GFDL), which span a wide range of feedbacks in response to uniform surface warming. The three GFDL models indicate that historical patterns of SST change systematically alter λ, supporting the hypothesized role for a “pattern effect” in historical climate sensitivity. However, we found that forcing one AGCM with the different CO2-induced SST warming patterns or model SST climatology from a suite of climate models from CMIP6 can only reproduce ∼10% the intermodel spread of CO2-induced λ, while the atmospheric model used determines the magnitude of λ (∼45%). This underscores the role of atmospheric model physics in altering λ, particularly the cloud-related schemes. In addition, we demonstrate that the nonlinear interaction between SST and AGCM has a nonnegligible role in affecting λ.
A Refined Method for Altimetry SSH Data Fusion to Enhance the Characterization of Kuroshio Extension: A Case Study
Authors: Zhou Chaojie , Cao Lei , Cui Wei , Huang Ying , Sun Ruili , Zhuang Zhanpeng 
Published: December 2024

Abstract
High-quality merged altimetry sea level products have been instrumental in analyzing oceanic dynamics, spanning global and regional sea level trends, and capturing interannual signals, but effectively characterizing mesoscale features remains a persistent issue. The essence of addressing this challenge lies in the selection of highly correlated data sources for fusion, within the confines of limited discrete observations from sea surface altimeters. To tackle this challenge, we propose a refined method focused on reducing the suboptimal interpolation window size and optimizing the mapping process, particularly emphasizing the enhancement of Kuroshio Extension (KE) characterization. By scrutinizing the spatial and temporal evolution of sea surface temperature (SST) fields, we have devised a modified strategy for selecting altimetry along-track data. This strategic approach facilitates the acquisition of more precise observations on a finer time scale, thereby circumventing the inclusion of altimetry observations with low correlation. To validate the efficacy of this approach, we performed a case study of sea surface height (SSH) data fusion in the KE region. As a result, the portrayal of KE intricacies, encompassing its axis and meandering, has markedly improved in the refined SSH gridded maps. A comparative analysis against drifter observations underscores the efficacy of the refined method. Velocity biases have been substantially reduced from −0.21 to 0.05 m s−1, while the correlation coefficient has surged from 0.64 to 0.90. Concurrently, the root-mean-square error has plummeted from 0.42 to 0.21 m s−1. These improvements signify significant strides toward more accurate and reliable characterizations of oceanic mesoscale features, particularly evident in the nuanced depiction of the KE.

Significance Statement
Accurately characterizing the mesoscale dynamical features of gridded sea surface height (SSH) products remains a significant challenge in oceanographic research. Previous studies have often employed a fixed configuration of critical mapping parameters, limiting the reduction of reconstruction errors. In this study, we address this challenge by proposing a refined method aimed at enhancing the characterization of mesoscale features. Our approach involves modifying the expression of the space–time correlation function and adjusting the size of the suboptimal interpolation window. We achieve this by carefully analyzing the spatial and temporal evolution of sea surface temperature (SST) fields. Through this refined methodology, we aim to improve the portrayal of details within the Kuroshio Extension (KE) region. A comparative analysis against drifter trajectories highlights the substantial benefits of our refined approach. The refined SSH map more accurately captures the interaction between mesoscale eddies and the KE, leading to a more comprehensive depiction of oceanic dynamics in this critical region.
Transoral Robotic Posterior Glottic Scar Lysis and Partial Arytenoidectomy: Report of a Novel Application of TORS for Benign Glottic Surgery
Authors: Panuganti Bharat Akhanda , Jeyarajan Harishanker 
Published: December 2024

Objectives: Transoral robotic surgery (TORS) for benign glottic conditions is scarcely represented in the literature. We aimed in this study to report on the technical feasibility of an explicitly transoral robotic approach for a patient with posterior glottic stenosis, and to highlight extant limitations in exposure and robotic instrumentation of the glottis. Methods: Retrospective chart review of a single patient undergoing a TORS approach to maximize the posterior glottic aperture. Results: A 42-year-old female patient with posterior glottic stenosis and a tracheotomy was consented for a robotic posterior glottic scar lysis, KTP-laser assisted partial arytenoidectomy, balloon dilation, and steroid injection. The da Vinci Intuitive Surgical single-port robotic platform was used with 2 robotic arms (needle driver and scissors), and an FK-WO transoral retractor with a straight tongue blade was deployed to facilitate endolaryngeal exposure. KTP laser fiber was passed through a robotic, semi-flexible drop-in guide, and manipulated with the needle driver. Case duration was 40 minutes. There were no perioperative or immediate post-operative complications noted on short-term follow-up. Conclusion: We demonstrate technical feasibility and equipoise between an explicitly robotic approach and a standard endoscopic approach to posterior glottic stenosis, a common glottic condition. Further technological development and adaptation of surgical technique are necessary to advance benign robotic laryngeal surgery.
Establishment of sex-specific reference intervals for PIVKA-II in Southwest China: A real-world data analysis
Authors: Wei Bin , Zheng Yalin , Li Lixin , Luo Limei , Guo Ying 
Published: December 2024

Objective We aim to establish the sex-related reference intervals (RIs) of PIVKA-II in southwest China by indirect method with the real-world data. Methods Between 29 July 2016 and 5 February 2024, PIVKA-II test data were collected from 120,780 healthy adult participants (aged 18 to 97 years) in the Laboratory Information System (LIS) of West China Hospital to establish reference intervals. Additionally, a validation group comprised of 2068 healthy adults was evaluated using the same detection algorithm and platform. Following the CLSI EP28-A3 guideline, Box-Cox transformation was applied for normal transformation, and outliers were identified using the Tukey method. Furthermore, we employed the standard normal deviate test (z-test) recommended by Harris and Boyd to determine whether to stratify reference intervals by age and sex subclasses. Results We successfully established population-specific RI for PIVKA-II in southwest China using an indirect method. By utilizing a robust dataset and conducting rigorous statistical analyses, we delineated sex-specific RIs, with values of 0–35 mAU/mL for males and 0–29 mAU/mL for females according to the normal distribution method, and 0–32 mAU/mL for males and 0–28 mAU/mL for females using the non-parametric method. These intervals are more suitable for the local population than those derived from manual methods. Conclusion These RIs provide valuable guidance for the accurate interpretation of PIVKA-II levels in the local population.