bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Peer‐to‐Peer Lending Have Resilience During the COVID‐19 Pandemic? Evidence From China
Authors: Wang Ziwei , Yang Haijun , Wu Harris 
Published: December 2024

ABSTRACTDoes Peer‐to‐Peer (P2P) lending, a digital FinTech platform, show resilience in response to COVID‐19 shocks? We examine this question by considering both the absorbing and adapting abilities based on psychological perceptions and objective infection cases. We collect data on infection cases, the Baidu search index, and 54,166 textual news articles to propose a novel perspective that incorporates both subjective psychological perceptions and objective infection cases to measure the response of P2P lending firms to COVID‐19 shocks. We calculate the extent of P2P lending's resilience using four metrics: maximum loss, total loss, recovery periods, and net impacts from local projections impulse responses. Our findings demonstrate that P2P lending displays resilience, as its total trade volume, new investors, and new investments initially decrease slightly and then rebound in response to the COVID‐19 shock. Psychological perception of COVID‐19 shocks, rather than objective infection, elicits a more pronounced response in the performance of P2P lending firms.
CGPDTA: An Explainable Transfer Learning‐Based Predictor With Molecule Substructure Graph for Drug‐Target Binding Affinity
Authors: Fan Qing , Liu Yingxu , Zhang Simeng , Ning Xiangzhen , Xu Chengcheng , Han Weijie , Zhang Yanmin , Chen Yadong , Shen Jun , Liu Haichun 
Published: December 2024

ABSTRACTIdentifying interactions between drugs and targets is crucial for drug discovery and development. Nevertheless, the determination of drug‐target binding affinities (DTAs) through traditional experimental methods is a time‐consuming process. Conventional approaches to predicting drug‐target interactions (DTIs) frequently prove inadequate due to an insufficient representation of drugs and targets, resulting in ineffective feature capture and questionable interpretability of results. To address these challenges, we introduce CGPDTA, a novel deep learning framework empowered by transfer learning, designed explicitly for the accurate prediction of DTAs. CGPDTA leverages the complementarity of drug–drug and protein–protein interaction knowledge through advanced drug and protein language models. It further enhances predictive capability and interpretability by incorporating molecular substructure graphs and protein pocket sequences to represent local features of drugs and targets effectively. Our findings demonstrate that CGPDTA not only outperforms existing methods in accuracy but also provides meaningful insights into the predictive process, marking a significant advancement in the field of drug discovery.
Exciton Thermodynamics in Pure Diamond
Authors: Cheng Lu , Zheng Wei 
Published: December 2024

AbstractLow‐temperature condensation thermodynamics is a fundamental research in the field of condensed matter physics. Prior studies have extensively explored the exciton condensation of indirect‐bandgap semiconductors like silicon (Si) and germanium (Ge), which predominantly focus on temperature effects but neglect the relationship between the initial condensed state and the external excitation power density. Here, based on pure diamond, the impact of excitation power density on condensed‐state thermodynamics is analyzed. With power density as a key variable, an inter‐dependency among exciton, electron–hole plasma, and electron–hole droplets can be observed in diamond. For instance, as the average excitation power density increases (6.15 to 246 mW cm−2), the exciton emission quenching temperature rises from 60 to 120 K. This is because the variation in initial states of the excitonic condensed phase under different excitation power densities leads to the changes in quenching energy, which subsequently affects the temperature dependence of the exciton quenching. This study pioneers a novel approach to explore luminescent thermodynamics in indirect‐bandgap semiconductors with both excitation power density and temperature considered as dimensions simultaneously.
Is Virtual Reality Lonely? The VR–Isolation Stereotype and Its Impact on VR Adoption
Authors: Slivkin Nikolay , Elgaaied‐Gambier Leila , Hamdi‐Kidar Linda 
Published: December 2024

ABSTRACTDespite the promise that virtual reality (VR) technology would be the new media of unprecedented connectedness, our investigation reveals that non‐owners perceive VR as a medium of social isolation, which may hinder its broader acceptance. Drawing on innovation resistance theory, we empirically test the existence of an implicit cognitive association between VR and isolation and then analyze the effects of this bias on VR adoption. Implicit Association Tests (IAT) used in Studies 1a (N = 199) and 1b (N = 200) identify a significant bias, associating VR with isolation. Study 2 (N = 401) further demonstrates the negative association of this bias with the societal image of VR users, potentially deterring willingness to engage with VR technology. Identification and intention to imitate emerge as relevant mediators. Studies 3a (N = 329) and 3b (N = 200) reveal that consumers' perceptions of isolation decrease when VR users are shown interacting with other people in real life (physical presence) but not when they are interacting through the VR platform (virtual presence). This research contributes to the understanding of innovation resistance and VR adoption by underscoring the importance of confronting and reshaping subconscious stereotypes about VR and its users.
Prevalence of Pathogenic Transthyretin Gene Variants in the Rocky Mountain Region
Authors: Jacoby Ellie , Quan Dianna , Todd Emily , Shortt Jonathan , Smith Harry , Rafaels Nicholas , Crooks Kristy ,   CCPM biobank Author Banner list
Published: December 2024

ABSTRACTIntroduction/AimsHereditary transthyretin amyloidosis (ATTRv) is a genetic condition caused by pathogenic variants in the transthyretin (TTR) gene resulting in multisystem amyloid deposition, especially in peripheral nerve and heart. Information on the prevalence of ATTRv in the United States is limited. The objective of this study was to understand the prevalence and genetic ancestry in the Val142Ile population in a large regional US population.MethodsColorado Center for Personalized Medicine (CCPM) biobank collects specimens from consenting adults seen throughout the University of Colorado Health System, a large tertiary healthcare system within the Rocky Mountain Region (RMR). Single nucleotide polymorphism (SNP) array genotyping and whole exome sequencing (WES) were performed for genetic research. Prevalence of TTR variants was studied.ResultsA total of 73,346 participants had genetic testing; 151 (0.21%) individuals had a pathogenic or likely pathogenic TTR variant. The most common variant was Val142Ile, making up 82.61% of TTR variants found. Over four percent of people with African non‐Hispanic ancestry had a Val142Ile variant.DiscussionThe most common TTR variant in our study was Val142Ile, the most common variant in the United States (US). Similar to other US‐based studies, affected individuals were predominantly of African, non‐Hispanic ancestry. The availability of treatments for symptomatic ATTRv patients raises opportunities and challenges for biobanks as the identification of at‐risk individuals places pressure on highly specialized centers and providers to see patients for screening and follow‐up.
Analysis of Combustion Properties of Tungsten/Copper Oxide Pyrotechnic Delay Composition
Authors: Hao Bo , Xu Caixian , Chen Geng , Lu Yuangen , Zhang Li 
Published: December 2024

ABSTRACTIn response to issues such as poor accuracy and unstable delay times encountered in the practical use of tungsten‐based delay compositions, an analysis of the combustion performance of tungsten‐based delay compositions with the addition of copper oxide was conducted. This study selected five tungsten‐based composite delay compositions prepared by blending tungsten‐based delay compositions with copper oxide at different content, aiming to investigate the influence of varying copper oxide proportions on the combustion characteristics of tungsten‐based delay compositions. Microscopic morphologies and thermal decomposition behaviors of the tungsten/copper oxide delay compositions were analyzed using scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), while combustion products were examined by X‐ray diffraction (XRD). The results indicate that copper oxide exerts a strong catalytic decomposition effect on tungsten‐based delay compositions. Specifically, a low concentration of copper oxide enhances the combustion rate of tungsten‐based delay compositions, while an increase in copper oxide content subsequently slows down the combustion rate. Notably, tungsten‐based delay compositions with 9% copper oxide content demonstrate high precision, good stability, and a relatively slow combustion rate, offering a wider range of adjustability for controlling the combustion speed of delay compositions and providing a feasible method for managing the delay time range in practical applications.
Crucial Role of c‐Myc/Monocarboxylate Transporter 4 Signaling in Capsaicin Induced Apoptotic and Anti‐Warburg Effects in Hepatocellular Carcinoma
Authors: Suh Jin Young , Sim Deok Yong , Ahn Chi‐Hoon , Park Su‐Yeon , Shim Bum‐Sang , Kim Bonglee , Lee Dae Young , Jeong Hyo Bong , Lee Hye Eun , Kim Sung‐Hoon 
Published: December 2024

ABSTRACTThough Capsaicin from chili peppers was known to have antitumor effects in several cancers, the underlying antitumor pathogenesis of Capsaicin is not clear to date. Thus, the antitumor mechanism of Capsaicin was explored in Hep3B and Huh7 hepatocellular carcinoma (HCC) cells in relation to c‐Myc/monocarboxylate transporter 4 (MCT4) signaling. To elucidate the antitumor mechanism of capsaicin, cytotoxicity assay, cell cycle analysis, Western blotting, RT‐qPCR, RNA interference, ELISA, immunoprecipitation, and mouse xenograft model were used in this work. Capsaicin increased the cytotoxicity, subG1 population, and the number of TUNEL‐positive bodies in Huh7 and Hep3B cells. Consistently, Capsaicin diminished the expression of pro‐PARP, HK2, PKM2, LDHA, glucose transporter type 1 (Glut1), c‐Myc, and monocarboxylate transporter 4 (MCT4) in Huh7 and Hep3B cells, along with decreased production of glucose, lactate, and ATP. However, a glycolysis end product pyruvate treatment reversed the capacity of Capsaicin to attenuate the expression of pro‐PARP, HK2, c‐Myc, and MCT4 in Hep3B cells. Furthermore, Capsaicin reduced c‐Myc stability in the presence of cycloheximide and induced c‐Myc ubiquitination in Hep3B cells, while c‐Myc directly binds to MCT4 as a lactate transporter and downstream of c‐Myc in Hep3B cells by immunoprecipitation and correlation factor (Spearman efficient = 0.0027). Furthermore, a preliminary analysis of an animal study reveals that Capsaicin significantly suppressed the growth of Hep3B cells inoculated in BALB/c nude mice without hurting body weight, liver, and spleen. Our findings provide novel evidence that Capsaicin exerts apoptotic and anti‐Warburg effect via c‐Myc/MCT4 signaling axis as a potent anticancer candidate for liver cancer therapy.
Simultaneous Photon and Phonon Lasing From Pumping Optomechanical Systems with a Two‐Tone Field
Authors: Eremeev Vitalie , Molinares Hugo , Correa Luis A. , He Bing 
Published: December 2024

AbstractAchieving simultaneous lasing of photons and phonons in optomechanical setups has great potential for applications in quantum information processing, high precision sensing and the design of hybrid photonic–phononic devices. Here, this possibility is explored with an optomechanical system driven by a two‐tone field. Whenever the difference between the driving frequencies matches the associated mechanical frequency, the photon and phonon populations are found to achieve steady‐state coherent oscillations, demonstrating a dual lasing phenomenon. Such drive–tone resonance condition can synchronize the phases of the photon and phonon fields, which facilitates a robust simultaneous lasing. Here, analytical insights into the joint amplification of the optical and mechanical modes are provided, and further confirm the dual lasing phenomenon by numerically calculating the relevant correlation functions and the power spectrum. This setup, consisting of a single optomechanical cavity, is simpler than previous realizations of dual lasing and provides a clean understanding of the underlying mechanisms. This work thus paves the way for the development of novel strategies for the optimisation of optomechanical interactions through tailored driving schemes.
Iodine/TBHP‐Promoted Cross Coupling of N‐Hydroxy Aryl Sulfonamides and Disulfides to Synthesize Unsymmetrical Thiosulfonates
Authors: Solanke Jayshree , Chatterjee Rana , Gat Savita , Dandela Rambabu 
Published: December 2024

AbstractAn efficient and novel method has been developed for the synthesis of structurally diverse unsymmetrical thiosulfonates via the oxidative coupling reactions of N‐hydroxy aryl sulfonamides and disulfides. The iodine and TBHP system enables the transformations to afford a variety of thiosulfonates with good to high yields. Furthermore, the large‐scale synthesis and practical application to access sulfonamide have been investigated. Notably, the present protocol offers easily accessible materials, a wide range of substrates, radical pathways, and metal‐free conditions.
Rhodamine‐Based Fluorescence Probe for Monitoring of Lysosomal pH: Spectroscopic Insights and Cellular Applications
Authors: Bhuinya Parnashree , Guha Subhabrata , Roy Swarnak , Dutta Prakash , Dey Sandeep Kumar , Sukul Pradip Kumar , Das Gaurav , Goswami Tamal , Kar Chirantan 
Published: December 2024

AbstractLysosomes play a pivotal role in various cellular processes, and their dysregulation can lead to severe health conditions. Monitoring lysosomal pH changes in real time is crucial for understanding and controlling lysosome‐related disorders. Herein, we report the development of a rhodamine‐based fluorescence probe, Rh‐Mo, designed for lysosomal pH sensing and lysosome‐specific imaging of human cells. Spectroscopic studies reveal that Rh‐Mo undergoes a color change and fluorescence enhancement in acidic conditions. The probe exhibits a high fluorescence quantum yield at acidic pH (0.84 at pH = 4.0) and a pKa value of 5.85, enabling sensitive detection of lysosomal pH changes. Theoretical calculations support the mechanism of protonation‐induced ring opening, elucidating the spectroscopic behavior of Rh‐Mo. In cellular studies, Rh‐Mo exhibits low cytotoxicity and efficient uptake and colocalization with lysosomes in MCF‐7 cells, highlighting its potential for bioimaging applications.
Ultrasensitive and Selective Detection of Chromium(VI) Using Biowaste Derived Fluorescent Nanoprobes of Hydrothermally Synthesized Carbon‐Dots
Authors: Ghosh Anupam , Boro Bibekjyoti , Chowdhury Sayak Saha , Ranjan Rahul , Dasgupta Nandita , Ranjan Shivendu 
Published: December 2024

AbstractThe Selective detection of hexavalent chromium Cr(VI), a highly toxic and carcinogenic form of chromium, at nanomolar concentration is critical due to its widespread industrial use and severe environmental and health impacts. This study presents the synthesis and application of carbon dots (CDs) derived from banana peel biowaste as a fluorescent nanosensor for the ultrasensitive and selective detection of Cr(VI). The CDs were synthesized through hydrothermal carbonization, yielding an average size of 1.9 nm, a quantum yield of 5%, and maximum fluorescence emission at 440 nm. The CDs displayed strong fluorescence quenching in Cr(VI), with minimal interference from other metal ions, highlighting their higher selectivity. CDs detection limit for Cr(VI) was determined as 52 nM or 2.7 ppb, significantly lower than those reported in recent studies, demonstrating the superior sensitivity. The quenching mechanism was further explored using X‐ray photoelectron spectroscopy (XPS), indicating that Cr(VI) undergoes reduction to Cr(III) upon interaction with the nitrogen‐containing surface functional groups of the CDs, suggesting a chemisorption process. This approach aligns with circular economy principles and supports achieving sustainable development goals (SDGs). Utilizing biowaste for synthesizing nanomaterials offers a promising pathway for creating environment friendly and cost‐effective sensors for detecting toxic metals.
(±) Citronellal Exerts Antidepressant and Modulatory Effects on Duloxetine Possibly Through Serotonin and Norepinephrine Reuptake Interaction Pathway: In Vivo Approach with Molecular Docking
Authors: Chowdhury Raihan , Bhuia Md. Shimul , Rakib Asraful Islam , Sheikh Salehin , Ahmmed Shakil , Situ Sharmita Ghosh , Ansari Siddique Akber , Ansari Irfan Aamer , Islam Muhammad Torequl 
Published: December 2024

AbstractThis study aims to assess the antidepressant and modulatory activities of citronellal (CIT) on duloxetine (DUX) and its possible underlying mechanisms through in vivo and in silico studies. Hence, the forced swimming test (FST), tail suspension test (TST), and open field test (OFT) were carried out. Mice were treated with different doses of CIT (50, 100, and 200 mg/kg, p.o.), while DUX (15 mg/kg, p.o.) was used as a positive control and a vehicle served as a negative control. Additionally, molecular docking was conducted to evaluate binding interactions. Results demonstrated that CIT dose‐dependently and significantly (p < 0.05) alleviated immobility time in both the FST and TST. At a dose of 200 mg/kg, CIT showed notable effects with immobility times of 42.17 ± 3.70 and 70.17 ± 2.56 s in the FST and TST, respectively. In combination therapy, CIT (100 mg/kg) modulated the activity of DUX. However, antidepressant activity is confirmed by the OFT test, which reduced the locomotion activity. Further, CIT exhibited a moderate binding affinity (−6.1 kcal/mol) toward both the serotonin and norepinephrine reuptake transporters (SRT and NRT) by forming several bonds. In conclusion, CIT demonstrated moderate antidepressant activity, possibly by interacting with SRT and NRT.
Construction of Optimal Orthogonal Partition
Authors: Wang Jing , Ren Yaoxin , Lin Xiao , Pang Shanqi 
Published: December 2024

ABSTRACTOrthogonal partitions play a crucial role in orthogonal array theory, design of experiments and quantum information theory. The optimisation of orthogonal partitions can improve the saturation percentages of orthogonal arrays (OAs) obtained by the orthogonal partition method. In particular, optimal orthogonal partitions of strength 1 are of great practical utility. However, there is still a scarcity of results about orthogonal partitions, especially optimal ones. In this paper, the definition of an optimal orthogonal partition is proposed, and we construct optimal orthogonal partitions of OAs by several construction methods, such as orthogonal partition method, difference scheme construction, generalised product construction and construction. As an application, we obtain various optimal orthogonal partitions and OAs with higher saturation percentages.
Enhancing self‐healing in bio‐mineralized concrete with steel slag aggregates and Bacillus subtilis
Authors: Ahmad Bilal , Shabbir Faisal , Raza Ali , Shaheen Nafeesa , Ahmed Mohd 
Published: December 2024

AbstractThis study investigates the impact of incorporating steel slag aggregates (SSAs) into bio‐mineralized concrete to enhance its SH properties. Bacillus subtilis vegetative cells are integrated to improve the concrete's healing efficacy. The effects of microbes were evaluated through damage healing measurements and the restoration of compressive strength (COS) over different durations. Characterization techniques, including x‐ray fluorescence, x‐ray diffraction (XRD), energy‐dispersive spectroscopy (EDS), and field‐emission scanning electron microscopy (FE‐SEM), were used to analyze the SH process in concrete using carbonated SSA as carrier media. The results demonstrated that SSA serves as an effective carrier for microbial proliferation, significantly improving damage‐healing performance. The immobilization of microbes (107 cells/mL) via SSA showed the highest fracture healing efficiency of 1.023 mm. The inclusion of microbes (107 cells/mL) in SSA aggregate concrete resulted in notable COS restoration after pre‐damage by 32.29%, 31.53%, and 18.97% at 3, 7, and 28 days, respectively. FE‐SEM, XRD, and EDS spot analysis identified calcite as SH precipitates, crucial for enhancing self‐healed concrete performance. The cost of microbial concrete is 115.25% higher than traditional concrete due to the additional expense of calcium lactate and microbial culture, but its SH properties can prevent early damage, extend the life of structures, reduce repair costs, and mitigate carbon emissions.
Navigating the Golden Triangle: The Need to Jointly Consider Modularization and Interface Choices When Making Performance, Cost, and Schedule Tradeoffs for Complex System Development
Authors: Topcu Taylan G. , Szajnfarber Zoe 
Published: December 2024

ABSTRACTDecomposition is a critical enabler of complex system development, as it enables both task specialization and efficiency through parallel work. The process of decomposing involves partitioning system parameters into tightly coupled modules and managing any cross‐module coupling by designing passive interfaces or through active coordination. A rich literature has developed algorithms and tools to support this process. However, we contend that this view has placed too much emphasis on module selection, and not enough on the interaction with interface design. This perspective has significant implications for lifecycle costs and development time. To that end, this study explores how earlier consideration of interface design can create more valuable options to better navigate performance, cost, and schedule tradeoffs. Specifically, through an abstract simulation experiment, we demonstrate that (1) a sequential approach that first selects modules and then designs interfaces to support those modules, yields lower performance than an integrated approach that considers modules and supporting interfaces simultaneously; and (2) this result is even stronger when schedule and cost are considered as part of the evaluation. In other words, an integrated approach provides more options for project managers seeking to navigate the performance‐cost‐schedule tradeoff known as the golden triangle. These results emphasize the need for a decomposition aid that adopts a holistic view of the optimization problem, accounting for interface creation, intra‐organization collaboration, and valuing nonperformance measures of effectiveness.