bluuebunny/crossref_metadata_2025_split huggingface dataset:
VS03.02: TOTALLY MINIMALLY INVASIVE IVORL LEWIS ESOPHAGECTOMY (TMIE) INDOCYANINE COLOR GREEN (ICG) FLUORESCENCE ANGIOGRAPHY ASSISTED
Authors: Cossu Andrea , Parise Paolo , Puccetti Francesco , Garutti Leonardo , Ferrari Carlo , Elmore Ugo , Rosati Riccardo 
Published: September 2018

Abstract

Description
Totally Minimally Invasive Ivor Lewis Esophagectomy has been proven feasible and safe in terms of overall mortality, morbidity and oncologic outcomes. Technical problems still exist in anastomotic fashioning and esophagogastric leakage represents the most feared complication. Its incidence is strictly related to technical difficulties and to the ischemia of the tissue involved in the anastomosis. We think angiography with Indocyanine Color Green can help the experienced surgeon to better evaluate the adequacy of the gastric tube therefore reducing the incidence of anastomotic leak.

Disclosure
All authors have declared no conflicts of interest.
VS03.07: RADICAL OPERATION OF ESOPHAGEAL CANCER UNDER 3D THORACOSCOPY
Authors: Jiang Jie , Yu Xiuyi , Geng Guojun , Liu Hongming 
Published: September 2018

Abstract

Description
The main steps of radical resection of esophageal carcinoma under 3D thoracoscope.

Disclosure
All authors have declared no conflicts of interest.
Solving (most) of a set of quadratic equalities: composite optimization for robust phase retrieval
Authors: Duchi John C , Ruan Feng 
Published: September 2018

Abstract
We develop procedures, based on minimization of the composition $f(x) = h(c(x))$ of a convex function $h$ and smooth function $c$, for solving random collections of quadratic equalities, applying our methodology to phase retrieval problems. We show that the prox-linear algorithm we develop can solve phase retrieval problems—even with adversarially faulty measurements—with high probability as soon as the number of measurements $m$ is a constant factor larger than the dimension $n$ of the signal to be recovered. The algorithm requires essentially no tuning—it consists of solving a sequence of convex problems—and it is implementable without any particular assumptions on the measurements taken. We provide substantial experiments investigating our methods, indicating the practical effectiveness of the procedures and showing that they succeed with high probability as soon as $m / n \ge 2$ when the signal is real-valued.
Germline-Restricted Chromosome (GRC) is Widespread among Songbirds
Authors: Torgasheva Anna A. , Malinovskaya Lyubov P. , Zadesenets Kira S. , Karamysheva Tatyana V. , Kizilova Elena A. , Pristyazhnyuk Inna E. , Shnaider Elena P. , Volodkina Valeria A. , Saiftdinova Alsu F. , Galkina Svetlana A. , Larkin Denis M. , Rubtsov Nikolai B. , M. Borodin Pavel 
Published: September 2018

AbstractThe genome of flying birds, the smallest among amniotes, reflects overweight of the extensive DNA loss over the unrestricted proliferation of selfish genetic elements, resulted in a shortage of repeated sequences and lack of B-chromosomes. The only exception of this rule has been described in zebra finch, which possesses a large germ-line restricted chromosome (GRC), transmitted via oocytes, eliminated from male postmeiotic cells and absent in somatic cell. It is considered as a rarity and its origin, content and function remain unclear. We discovered that all songbirds possess GRC: in various size and genetic content it is present in all fifteen songbird species investigated and absent from germ-line genomes of all eight species of other bird orders examined. Our data based on fluorescentin situhybridization of DNA probes derived from GRCs of four different Passeri species and their sequencing indicate that the GRCs show low homology between avian species. They contain fragments of the somatic genomes, which include various unique and repetitive sequences. We propose that the GRC has formed in the common ancestor of the extant songbirds and undergone subsequent divergence. GRC presence in the germ line of every songbird studied indicate that it could contain genetic element(s) indispensable for gametogenesis, which are yet to be discovered.
Systemic inflammation and risk of age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy
Authors: Babu Hemalatha , Ambikan Anoop T , Gabriel Erin E , Akusjärvi Sara Svensson , Palaniapan Alangudi Natarajan , Sundaraj Vijila , Mupanni Naveen Reddy , Sperk Maike , Cheedarla Narayanaiah , Sridhar Rathinam , Tripathy Srikanth P , Nowak Piotr , Hanna Luke Elizabeth , Neogi Ujjwal 
Published: September 2018

AbstractThe ART program in low- and middle-income countries (LMIC) like India, has a public health approach with the standardized regimen for all people living with HIV (PLHIV). Based on the evidence from high-income countries (HIC), the successful implication and scale-up of ART in India, the risk of an enhanced and accentuated onset of premature-aging or age-related diseases could be observed in PLHIV. However, very limited data is available on residual inflammation and immune activation in the populations who are on first-generation anti-HIV drugs like zidovudine and lamivudine that had more toxic side effects. Therefore, the aim of the present study was to evaluate the levels of systemic inflammation and understand the risk of age-associated diseases in PLHIV on long-term suppressive ART using a large number of biomarkers of the inflammation and immune activation. Blood samples were obtained from therapy naïve PLHIV (Pre-ART, n=43), PLHIV on ART for >5 years (ART, n=53), and HIV-negative healthy controls (HIVNC, n=41). Samples were analyzed for 92 markers of inflammation, sCD14, sCD163, and telomere length. Several statistical tests were performed to compare the groups under study. Multivariate linear regression was used to investigate the associations. Despite a median duration of eight years of successful ART, sCD14 (p<0.001) and sCD163 (p=0.04) levels continued to be significantly elevated in ART group as compared to HIVNC. Eleven inflammatory markers, including 4E-BP1, ADA, CCL23, CD5, CD8A, CST5, MMP1, NT3, SLAMF1, TRAIL and TRANCE, were found to be significantly different (p<0.05) between the groups. Many of these markers are associated with age-related co-morbidities including cardiovascular disease, neurocognitive decline and some of these markers are being reported for the first time in the context of HIV-induced inflammation. Linear regression analysis showed a significant negative association between HIV-1-positivity and telomere length (p<0.0001). In ART-group CXCL1 (p=0.048) and TGF-α (p=0.026) have a significant association with increased telomere length and IL-10RA was significantly associated with decreased telomere length (p=0.042). This observation warrants further mechanistic studies to generate evidence to highlight the need for enhanced treatment monitoring and special interventions in HIV-infected individuals.
A post-transcriptional program of chemoresistance by AU-rich elements and TTP
Authors: Lee Sooncheol , Micalizzi Douglas , Truesdell Samuel S , Bukhari Syed IA , Boukhali Myriam , Lombardi-Story Jennifer , Kato Yasutaka , Choo Min-Kyung , Dey-Guha Ipsita , Nicholson Benjamin T. , Myers David T. , Lee Dongjun , Mazzola Maria A , Raheja Radhika , Langenbucher Adam , Haradhvala Nicholas J. , Lawrence Michael , Gandhi Roopali , Tiedje Christopher , Diaz-Munoz Manuel , Sweetser David A , Sykes David , Haas Wilhelm , Haber Daniel A. , Maheswaran Shyamala , Vasudevan Shobha 
Published: September 2018

AbstractBackgroundQuiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcriptional regulation contributes to their chemoresistance remains unknown.ResultsWe induced chemoresistant and quiescent (G0) leukemic cells by serum-starvation or chemotherapy treatment. To study post-transcriptional regulation in G0 leukemic cells, we systematically analyzed their transcriptome, translatome, and proteome. We find that our resistant G0 cells recapitulate gene expression profiles of in vivo chemoresistant leukemic and G0 models. In G0 cells, canonical translation initiation is inhibited; yet we find that inflammatory genes are highly translated, indicating alternative post-transcriptional regulation. Importantly, AU-rich elements (AREs) are significantly enriched in the up-regulated G0 translatome and transcriptome. Mechanistically, we find the stress-responsive p38 MAPK-MK2 signaling pathway stabilizes ARE mRNAs by phosphorylation and inactivation of mRNA decay factor, tristetraprolin (TTP) in G0. This permits expression of ARE-bearing TNFα and DUSP1 that promote chemoresistance. Conversely, inhibition of TTP phophorylation by p38 MAPK inhibitors and non-phosphorylatable TTP mutant decreases ARE mRNAs and sensitizes leukemic cells to chemotherapy. Furthermore, co-inhibiting p38 MAPK and TNFα—prior to or along with chemotherapy—substantially reduced chemoresistance in primary leukemic cells ex vivo and in vivo.ConclusionsThese studies uncover post-transcriptional regulation underlying chemoresistance in leukemia. Our data reveal the p38 MAPK-MK2-TTP axis as a key regulator of expression of ARE bearing mRNAs that promote chemoresistance. By disrupting this pathway, we developed an effective combination therapy against chemosurvival.
The effect of physiological and measurement noise on the estimate of individual muscle force from indirect measurements of muscle activity
Authors: Zonnino Andrea , Sergi Fabrizio 
Published: September 2018

ABSTRACTSeveral forward dynamics estimators have been proposed to quantify individual muscle force using non-invasive measurements of muscle activity. None of them, however, addresses the inaccuracy that arises when measurements are available only from a subset of the muscles involved in the movement under analysis. We present a novel estimator that integrates a forward dynamics estimation approach with knowledge of the optimal contraction strategy to obtain accurate estimates of individual muscle force when measurements of muscle activity are not available for all muscles. A following in-silico characterization showed that when trying to estimate forces form the forearm muscles acting around the wrist joint, our novel estimator is able to decrease the mean estimation bias by about 25% of the true value of muscle force. With a sensitivity analysis, we show that the model-based estimator is robust against physiological variability in muscle co-contraction strategy.
Redundant and cryptic enhancer activities of the Drosophilayellowgene
Authors: Kalay Gizem , Lachowiec Jennifer , Rosas Ulises , Dome Mackenzie R. , Wittkopp Patricia 
Published: September 2018

Abstractcis-regulatory sequences known as enhancers play a key role in regulating gene expression. Evolutionary changes in these DNA sequences contribute to phenotypic evolution. The Drosophilayellowgene, which is required for pigmentation, has emerged as a model system for understanding howcis-regulatory sequences evolve, providing some of the most detailed insights available into how activities of orthologous enhancers have diverged between species. Here, we examine the evolution ofyellow cis-regulatory sequences on a broader scale by comparing the distribution and function ofyellowenhancer activities throughout the 5’ intergenic and intronic sequences ofDrosophila melanogaster,Drosophila pseudoobscura, andDrosophila willistoni. We find thatcis-regulatory sequences driving expression in a particular tissue are not as modular as previously described, but rather have many redundant and cryptic enhancer activities distributed throughout the regions surveyed. Interestingly, cryptic enhancer activities of sequences from one species often drove patterns of expression observed in other species, suggesting that the frequent evolutionary changes inyellowexpression observed among Drosophila species may be facilitated by gaining and losing repression of pre-existingcis-regulatory sequences.
Accordion-like collagen fibrils suggested by P-SHG image modeling : implication in liver fibrosis
Authors: Rouède D. , Schaub E. , Bellanger J-J. , Ezan F. , Tiaho F. 
Published: September 2018

ABSTRACTSecond-order non-linear optical anisotropy parameter ρ = χ33 / χ31 is calculated for collagen-richt issues considering both a single dominant molecular hyperpolarizability tensor element β333 = β at single helix level and a priori known submicrometric triple helical organization of collagen molecules. Modeling is further improved by taking account of Poisson photonic shot noise of the detection system and simple supra-molecular fibrillar arrangements in order to accurately simulate the dispersion of ρ values in collagen-rich tissues such as tendon, skin and liver vessels. From combined P-SHG experiments and modeling, we next correlate experimental and theoretical statistical distributions of ρ. Our results highlight that the dispersion of experimental ρ values is mainly due to (i) Poisson photonic shot noise in tendon and skin, which proves to have a preponderant effect in P-SHG experiments (ii) variance of supercoil angles of accordion-like fibrils in vessels that is further reduced during the development of liver fibrosis therefore contributing to the rigidity of the tissue. These results open new avenue for future modeling correlating the dispersion of ρ values in P-SHG experiments and the fibrillar architecture as well as the mechanical stiffness of patho-physiological extracellular matrices in collagen tissues.
Speech-based identification of L-DOPA ON/OFF state in Parkinson’s Disease subjects
Authors: Norel R. , Agurto C. , Rice J.J. , Ho B.K. , Cecchi G.A. 
Published: September 2018

AbstractBackgroundParkinson’s disease patients (PDP) are evaluated using the unified Parkinson’s disease rating scale (UP-DRS) to follow the longitudinal course of the disease. UP-DRS evaluation is performed by a neurologist, and hence its use is limited in the evaluation of short-term (daily) fluctuations. Subjects taking L-DOPA as part of treatment to reduce symptoms exhibit motor fluctuations as a common complication.ObjectivesThe aim of the study is to assess the use of speech analysis as a proxy to continuously monitor PDP medication state.MethodsWe combine acoustic, prosody, and semantic features to characterize three speech tasks (picture description, reverse counting and diadochokinetic rate) of 25 PDP evaluated under different medication states: “ON” and “OFF” L-DOPA.ResultsClassification of medication states using features extracted from audio recordings results in cross-validated accuracy rates of 0.88, 0.84 and 0.71 for the picture description, reverse counting and diadochokinetic rate tasks, respectively. When adding feature selection and semantic features, the accuracy rates increase to 1.00, 0.96 and 0.83 respectively; thus reaching very high classification accuracy on 3 different tasks.ConclusionsWe show that speech-based features are highly predictive of medication state. Given that the highest performance was obtained with a very naturalistic task (picture description), our results suggest the feasibility of accurate, non-burdensome and high-frequency monitoring of medication effects.
The speed-accuracy tradeoff reveals flexible access to accumulating sensory evidence during human decision making
Authors: Nelli Stephanie , Itthipuripat Sirawaj , Rungratsameetaweemana Nuttida , Serences John T. 
Published: September 2018

AbstractDecisions made about identical perceptual stimuli can be radically different under changing task demands. For example, the need to make a fast decision undermines the accuracy of that decision, a well-documented effect termed the speed-accuracy tradeoff (SAT). Models of the SAT are generally based on theories of decision making in which responses are triggered only after sensory evidence accumulation terminates at a set threshold. Within this accumulate-to-bound framework, speed pressure operates by lowering the response threshold, allowing for faster responses at the expense of accumulated sensory evidence. To empirically examine the mechanisms necessary for adaptively adjusting the speed and accuracy of decisions, we used an event-related potential that indexes sensory evidence accumulation in the human brain. Instead of lowering response thresholds, we found that speed pressure adaptively shifts responses to occur close to where the rate of evidence accumulation peaks. Moreover, responses are not triggered automatically by the termination of the accumulation process, as sensory evidence continues to build after speeded decisions. Together these results suggest that response processes adaptively access accumulating sensory evidence depending on task demands and support parallel over serial models of decision making.
Functional characterization of retinal ganglion cells using tailored nonlinear modeling
Authors: Shi Qing , Gupta Pranjal , Boukhvalova Alexandra , Singer Joshua H. , Butts Daniel A. 
Published: September 2018

AbstractThere are 20-50 functionally- and anatomically-distinct ganglion cell types in the mammalian retina; each type encodes a unique feature of the visual world and conveys it via action potentials to the brain. Individual ganglion cells receive input from unique presynaptic retinal circuits, and the characteristic patterns of light-evoked action potentials in each ganglion cell type therefore reflect computations encoded in synaptic input and in postsynaptic signal integration and spike generation. Unfortunately, there is a dearth of tools for characterizing retinal ganglion cell computation. Therefore, we developed a statistical model, the separable Nonlinear Input Model, capable of characterizing the large array of distinct computations reflected in retinal ganglion cell spiking. We recorded ganglion cell responses to a correlated noise (“cloud”) stimulus designed to accentuate the important features of retinal processing in an in vitro preparation of mouse retina and found that this model accurately predicted ganglion cell responses at high spatiotemporal resolution. It identified multiple receptive fields (RFs) reflecting the main excitatory and suppressive components of the response of each neuron. Most significantly, our model succeeds where others fail, accurately identifying ON-OFF cells and segregating their distinct ON and OFF selectivity and demonstrating the presence of different types of suppressive receptive fields. In total, our computational approach offers rich description of ganglion cell computation and sets a foundation for relating retinal computation to retinal circuitry.
Microcredit and technology adoption
Authors: Mariyono Joko 
Published: September 2018

PurposeThe purpose of this paper is to analyze the impact of microcredit and agronomic technology on farm households’ prosperity, and to determine important factors affecting farmers’ access to microcredit and technology adoption in Indonesian intensive farming.Design/methodology/approachThe focus of the study was farmers engaging with chili-based agribusiness in rural areas. Data for this study were compiled from a survey that interviewed 250 farm households. Samples of the study were randomly selected from chili farming community in three regions of Java during 2013–2014. Data were analyzed using structural equation modeling (SEM).FindingsMicrocredit provided positive direct and indirect impacts on household prosperity. Microcredit indirectly impacted the well-being through the mediation of technology adoption. Farmers’ characteristics and agribusiness environment determined farmers’ decision to access microcredit and adopt advanced technology. Microcredit and technology have enhanced farmers’ well-being through pathways that enabled farmers to develop farming scale.Practical implicationsThe government should offer more alternatives to advanced technology and flexible procedures of access to credit at the same time to ensure sustained pathways of rural economic growth in Indonesia.Originality/valueThis paper applied a SEM to a proposition of simultaneous causal interrelations among microcredit, technology and farmers’ prosperity.
Applying the physics of notation to the evaluation of a security and privacy requirements engineering methodology
Authors: Diamantopoulou Vasiliki , Mouratidis Haralambos 
Published: September 2018

Purpose
The purpose of this study is the analysis of a security and privacy requirements engineering methodology. Such methodologies are considered an important part of systems’ development process when they contain and process a large amount of critical information, and thus need to remain secure and ensure privacy.

Design/methodology/approach
These methodologies provide techniques, methods and norms for tackling security and privacy issues in information systems. In this process, the utilisation of effective, clear and understandable modelling languages with sufficient notation is of utmost importance, as the produced models are used not only among IT experts or among security specialists but also for communication among various stakeholders, in business environments or among novices in an academic environment.

Findings
The qualitative analysis revealed a partial satisfaction of these principles.

Originality/value
This paper evaluates the effectiveness of a security and privacy requirements engineering methodology, namely, Secure Tropos, on the nine principles of the theory of notation.
Is too much inclusive leadership a good thing? An examination of curvilinear relationship between inclusive leadership and employees’ task performance
Authors: Xiaotao Zheng , Yang Xiaoling , Diaz Ismael , Yu Mingchuan 
Published: September 2018

PurposeThe purpose of this paper is to examine the inclusive leadership’s too-much-of-a-good-thing effect (TMGT effect) and illustrate the possibility of the potential drawbacks of inclusive leadership.Design/methodology/approachIn total, 191 questionnaires were valid and used in the study. Employee participants were asked to report their direct supervisor’s inclusive leadership. Employees’ direct supervisors were asked to rate employees’ task performance to minimize common method variance. The authors use regression analysis to test the hypothesis.FindingsAn inverted U-shape characterizes the relationship between inclusive leadership and subordinates’ task performance. Specifically, employees’ task performance is low when the supervisor’s inclusive leadership is low; task performance increases when inclusive leadership is from low to moderate levels, and task performance decreases when inclusive leadership is from moderate to high levels.Originality/valueThe study sheds light on inclusive leadership, especially the inclusive leadership in Chinese context. In addition, this finding is important as it investigates the inclusion’s TMGT effect which is rare in organizational research, and the findings also provide additional evidence of TMGT effect in management fields.