bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creencias y actitudes de jóvenes universitarios sevillanos hacia las variedades normativas del español de España: andaluza, canaria y castellana
Authors: Santana Marrero Juana 
Published: May 2018

Resumen
En este trabajo se estudia la percepción de un grupo de estudiantes universitarios sevillanos, sin conocimientos especializados sobre la variación geográfica y social del español, hacia las variedades andaluza, canaria y castellana. Los resultados revelan la presencia significativa de juicios negativos hacia su propia modalidad de habla, tanto en lo relativo a la pronunciación como a su asociación con un estatus social bajo. No obstante, se produjo un incremento de consideraciones positivas cuando se les pidió la valoración de los habitantes de su región, los andaluces. La variedad castellana, que se identificó como la forma de hablar más prestigiosa, recibió las valoraciones más positivas: fue considerada una pronunciación clara y sus hablantes se asociaron a una posición social elevada. En tercer lugar, las creencias sobre la variedad canaria reforzaron algunos tópicos como la dulzura del acento.
A Zn(II) complex from an imidazolyl-thiophene ligand: synthesis, structural characterization, and fluorescence
Authors: Kuai Hai-Wei , Hu Tao , Jiang Ding-Yun , Zhu Xiao-Hong 
Published: May 2018

Abstract
The hydrothermal reaction of ZnSO4 with 2,5-di(1H-imidazol-4-yl)thiophene (L) at 100°C yields a new complex [Zn(L)(SO4)]
n
(1). Complex 1 has been characterized by single-crystal X-ray diffraction, IR spectroscopy, and elemental and thermogravimetric analyses. It crystallizes in the monoclinic system, space group P21/c with Z=4, and shows a (44.62) network structure. Complex 1 shows fluorescence. Single crystals of L·2H2O were accidentally obtained in hydrothermal reaction attempts of L with MnCl2 at 120°C.
Individual and Combined Effect of Inter-repetition Rest and Elastic Bands on Jumping Potentiation in Resistance-Trained Men
Authors: Nickerson Brett S. , Williams Tyler D. , Snarr Ronald L. , Park Kyung-Shin 
Published: May 2018

Abstract
Nickerson, BS, Williams, TD, Snarr, RL, and Park, K-S. Individual and combined effect of inter-repetition rest and elastic bands on jumping potentiation in resistance-trained men. J Strength Cond Res 33(8): 2087–2093, 2019—The purpose of this study was to determine the individual and combined effects of cluster sets (CS) and elastic bands for jumping potentiation in resistance-trained men. Twelve resistance-trained men (age: 22 ± 3 years) participated in this study. In a random order, participants completed 1 set of 3 repetitions at 85% 1-repetition maximum for the parallel back squat: (a) traditional set with continuous repetitions; (b) continuous repetitions with elastic bands (BANDS); (c) CS with 30 seconds of rest between each repetition (CS30); and (d) CS with 30 seconds of rest between each repetition and elastic bands (CS + BANDS). Vertical jump height (JH) and peak power (PP) were measured before exercise (baseline) and at 1, 4, 7, and 10 minutes after exercise for each condition. Results revealed that PP at 10 minutes was significantly higher than 7 minutes for BANDS (p = 0.035) and that 4 and 7minutes were both significantly higher than baseline for CS + BANDS (p = 0.008 and 0.031, respectively). No other differences were observed. There were medium effect sizes (ESs) for PP with BANDS (ES = 0.58 at 10 minutes), CS30 (ES = 0.53 and 0.64 at 7 and 10 minutes, respectively), and CS + BANDS (ES = 0.64, 0.78, and 0.66 at 4, 7, and 10 minutes, respectively). All remaining ES for JH and PP were trivial to small. Based on the moderate magnitude of effect, BANDS, CS30, and CS + BANDS were effective at potentiating vertical jump power. CS + BANDS is a more practical approach to potentiate vertical jump power when athletes are under strict time restraints.
Polarized vs. Threshold Training Intensity Distribution on Endurance Sport Performance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Rosenblat Michael A. , Perrotta Andrew S. , Vicenzino Bill 
Published: May 2018

Abstract
Rosenblat MA, Perrotta AS, and Vicenzino B. Polarized vs. threshold training intensity distribution on endurance sport performance: A systematic review and meta-analysis of randomized controlled trials. J Strength Cond Res 33(12): 3491–3500, 2019—The objective of this review was to systematically search the literature to identify and analyze data from randomized controlled trials that compare the effects of a polarized training model (POL) vs. a threshold training model (THR) on measurements of sport performance in endurance athletes. This systematic review and meta-analysis is registered with PROSPERO (CRD42016050942). The literature search was performed on November 6, 2016 and included SPORTDiscus (1800–present), CINAHL Complete (1981–present), and Medline with Full Text (1946–present). Studies were selected if they included: random allocation, endurance-trained athletes with greater than 2 years of training experience and Vo
2max/peak >50 ml·kg·min−1, a POL group, a THR group, assessed either internal (e.g., Vo
2max) or external (e.g., time trial) measurements of endurance sport performance. The databases SPORTDiscus, Medline and CINAHL yielded a combined 329 results. Four studies met the inclusion criteria for the qualitative analysis, and 3 for the meta-analysis. Two of the 4 studies included in the review scored a 4/10 on the PEDro Scale and 2 scored a 5/10. With respect to outcome measurements, 3 studies included time-trial performance, 3 included Vo
2max or Vo
2peak, 2 studies measured time-to-exhaustion, and one study included exercise economy. There was sufficient data to conduct a meta-analysis on time-trial performance. The pooled results demonstrate a moderate effect (ES = −0.66; 95% CI: −1.17 to −0.15) favoring the POL group over the THR group. These results suggest that POL may lead to a greater improvement in endurance sport performance than THR.
Effective Stress Strength Parameters of Clays from DMT
Authors: Ouyang Zhongkun , Mayne Paul W. 
Published: May 2018

Abstract
In this study, an established effective stress limit plasticity solution for piezocone penetration tests (CPTu) in clay developed by the Norwegian Institute of Technology (NTH) for evaluating the effective stress friction angle (ϕ′) is extended to flat plate dilatometer tests (DMT) readings. A nexus between CPTu and DMT is built through spherical cavity expansion solutions for undrained penetration to link the cone tip resistance (qt) and shoulder porewater pressure (u2) from CPTu to the measured contact pressure (p0) and expansion pressure (p1) obtained from DMT in soft to firm intact clays. Data from 49 paired sets of CPTu-DMT soundings in a variety of clays are used to support and validate the links. A variety of soils ranging from lean to plastic clays and clayey silts from marine, alluvial, lacustrine, deltaic, and glaciofluvial origins are subjected to flat DMTs, and the measurements are utilized to evaluate the effective stress friction angle (ϕ′). Data from 46 clays are compiled to examine the DMT-interpreted ϕ′ values in comparison with laboratory benchmark ϕ′ values obtained from CAUC or isotropically consolidated undrained triaxial compression tests on high-quality samples. An approximate inversion of the theoretical solution is derived to allow ϕ′ profiles to be determined with depth. Four well-documented DMT examples, including two natural clay sites and two chamber test series (one pressurized and the other unpressurized), are presented to illustrate the NTH procedures.
CONSIDERAÇÕES SOBRE O DISCURSO DA ECOLOGIA HUMANA E SOCIAL
Authors: Berg Rosana Da Silva , Tavares Ana Beatriz 
Published: May 2018

A ecopedagogia vem assumindo papel crítico na reorientação das pessoas envolvidas com o meio ambiente e com o cuidado com a casa comum. O objetivo desta resenha é analisar as propostas educacionais de três documentos fundadores da ecopedagogia social contemporânea: Carta da Terra, Ecologia, mundialização e espiritualidade e Laudato Si, com foco nas orientações para mudança de atitude e comportamento em relação à comunidade de vida do planeta. A tríade se justifica, por razões de convergência de ideias, de orientação filosófica e de metas. A partir da análise das orientações e princípios dos três documentos, formulamos propostas de intervenção. Fundamo-nos nas afirmações que são consensuais, alicerçadas em dados empíricos e em evidências robustas, sobre atitudes e práticas humanas, relativas à subsistência, ao lucro e ao descarte e legitimamos uma proposta de reorientação ecológica. No correr da análise, discutimos afirmações que parecem, à primeira vista, polêmicas ou inconsistentes e ressaltamos as mais produtivas.
Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila
Authors: Yamakawa Tomoko , Atsumi Yu , Kubo Shiori , Yamagishi Ami , Morita Izumi , Matsuno Kenji 
Published: May 2018

Abstract
Notch signaling plays crucial roles in intercellular communications. In Drosophila, the pecanex (pcx) gene, which encodes an evolutionarily conserved multi-pass transmembrane protein, appears to be required to activate Notch signaling in some contexts, especially during neuroblast segregation in the neuroectoderm. Although Pcx has been suggested to contribute to endoplasmic reticulum homeostasis, its functions remain unknown. Here, to elucidate these roles, we performed genetic modifier screens of pcx. We found that pcx heterozygotes lacking its maternal contribution exhibit cold-sensitive lethality, which is attributed to a reduction in Notch signaling at decreased temperatures. Using sets of deletions that uncover most of the second and third chromosomes, we identified four enhancers and two suppressors of the pcx cold-sensitive lethality. Among these, five genes encode known Notch-signaling components: big brain, Delta (Dl), neuralized (neur), Brother of Bearded A (BobA), a member of the Bearded (Brd) family, and N-ethylmaleimide-sensitive factor 2 (Nsf2). We showed that BobA suppresses Dl endocytosis during neuroblast segregation in the neuroectoderm, as Brd family genes reportedly do in the mesoderm for mesectoderm specification. Analyses of Nsf2, a key regulator of vesicular fusion, suggested a novel role in neuroblast segregation, which is distinct from Nsf2’s previously reported role in imaginal tissues. Finally, jim lovell, which encodes a potential transcription factor, may play a role in Notch signaling during neuroblast segregation. These results reveal new research avenues for Pcx functions and Notch signaling.
Functional Impact of the H2A.Z Histone Variant During Meiosis in Saccharomyces cerevisiae
Authors: González-Arranz Sara , Cavero Santiago , Morillo-Huesca Macarena , Andújar Eloisa , Pérez-Alegre Mónica , Prado Félix , San-Segundo Pedro 
Published: May 2018

Abstract
Among the collection of chromatin modifications that influence its function and structure, the substitution of canonical histones by the so-called histone variants is one of the most prominent actions. Since crucial meiotic transactions are modulated by chromatin, here we investigate the functional contribution of the H2A.Z histone variant during both unperturbed meiosis and upon challenging conditions where the meiotic recombination checkpoint is triggered in budding yeast by the absence of the synaptonemal complex component Zip1. We have found that H2A.Z localizes to meiotic chromosomes in an SWR1-dependent manner. Although meiotic recombination is not substantially altered, the htz1 mutant (lacking H2A.Z) shows inefficient meiotic progression, impaired sporulation, and reduced spore viability. These phenotypes are likely accounted for by the misregulation of meiotic gene expression landscape observed in htz1. In the zip1 mutant, the absence of H2A.Z results in a tighter meiotic arrest imposed by the meiotic recombination checkpoint. We have found that Mec1-dependent Hop1-T318 phosphorylation and the ensuing Mek1 activation are not significantly altered in zip1 htz1; however, downstream checkpoint targets, such as the meiosis I-promoting factors Ndt80, Cdc5, and Clb1, are drastically downregulated. The study of the checkpoint response in zip1 htz1 has also allowed us to reveal the existence of an additional function of the Swe1 kinase, independent of CDK inhibitory phosphorylation, which is relevant to restrain meiotic cell cycle progression. In summary, our study shows that the H2A.Z histone variant impacts various aspects of meiotic development adding further insight into the relevance of chromatin dynamics for accurate gametogenesis.
<i>La masonería en Andalucía y la represión durante el franquismo</i>, editado por Fernando Martínez López y Leandro Álvarez Rey
Authors: Pozuelo Andrés Yván 
Published: May 2018

Reseña del libro La masonería en Andalucía y la represión durante el franquismo, editado por Fernando Martínez López y Leandro Álvarez Rey. Madrid: Biblioteca Nueva, 2017. 344 páginas. ISBN-10: 8416938253. ISBN-13: 978-8416938254.
<i>Masones y masonería en la Costa Rica de los albores de la Modernidad (1865-1899)</i> de Ricardo Martínez Esquivel
Authors: Del Solar Felipe Santiago 
Published: May 2018

Reseña del libro Masones y masonería en la Costa Rica de los albores de la Modernidad (1865-1899) de Ricardo Martínez Esquivel. San José: Editorial de la Universidad de Costa Rica, 2017. 345 páginas. ISBN: 978-9968-46-654-7.
Ramucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open-Label, Phase I Trial (JVDF)
Authors: Arkenau Hendrik-Tobias , Martin-Liberal Juan , Calvo Emiliano , Penel Nicolas , Krebs Matthew G. , Herbst Roy S. , Walgren Richard A. , Widau Ryan C. , Mi Gu , Jin Jin , Ferry David , Chau Ian 
Published: May 2018

AbstractLessons LearnedRamucirumab plus pembrolizumab revealed no unexpected safety findings in patients with advanced or metastatic biliary tract cancer, which is consistent with reports of other tumor cohorts within this phase Ia/b trial. Ramucirumab plus pembrolizumab did not demonstrate an improvement in overall survival when compared with historical controls in biomarker unselected, heavily pretreated patients with advanced or metastatic biliary tract cancer. Patients with programmed death-ligand 1 (PD-L1)-positive tumors had improved overall survival compared with patients with PD-L1-negative disease.BackgroundFew treatment options exist for patients with advanced biliary tract cancer (BTC) following progression on gemcitabine-cisplatin. Preclinical evidence suggests that simultaneous blockade of vascular endothelial growth factor receptor 2 (VEGFR-2) and programmed death 1 (PD-1) or programmed death-ligand 1 (PD-L1) enhances antitumor effects. We assessed the safety and efficacy of ramucirumab, an IgG1 VEGFR-2 antagonist, with pembrolizumab, an IgG4 PD-1 antagonist, in biomarker-unselected patients with previously treated advanced or metastatic BTC.MethodsPatients had previously treated advanced or metastatic adenocarcinoma of the gallbladder, intrahepatic and extrahepatic bile ducts, or ampulla of Vater. Ramucirumab 8 mg/kg was administered intravenously on days 1 and 8 with intravenous pembrolizumab 200 mg on day 1 every 3 weeks. The primary endpoint was safety and tolerability of the combination. Secondary endpoints included objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).ResultsTwenty-six patients were treated at 12 centers in five countries. Hypertension was the most common grade 3 treatment-related adverse event (TRAE), occurring in five patients. One patient experienced a grade 4 TRAE (neutropenia), and no treatment-related deaths occurred. Objective response rate was 4%. Median progression-free survival and overall survival were 1.6 months and 6.4 months, respectively.ConclusionRamucirumab-pembrolizumab showed limited clinical activity with infrequent grade 3–4 TRAEs in patients with biomarker-unselected progressive BTC.
A Phase I Study of Ganetespib and Ziv-Aflibercept in Patients with Advanced Carcinomas and Sarcomas
Authors: Meehan Robert , Kummar Shivaani , Do Khanh , O'Sullivan Coyne Geraldine , Juwara Lamin , Zlott Jennifer , Rubinstein Larry , Doroshow James H. , Chen Alice P. 
Published: May 2018

Abstract

Lessons Learned
The combination of the antiangiogenic agent ziv-aflibercept and the heat shock protein 90 inhibitor ganetespib was associated with several serious and unexpected adverse events and was not tolerable on the dosing schedule tested. Studies such as these emphasize the importance of considering overlapping toxicities when designing novel treatment combination regimens.

Background
Although inhibition of angiogenesis is an effective strategy for cancer treatment, acquired resistance to antiangiogenic therapy is common. Heat shock protein 90 (Hsp90) is a molecular chaperone that regulates various oncogenic signaling pathways involved in acquired resistance and has been shown to play a role in angiogenesis. Combining an antiangiogenic agent with an Hsp90 inhibitor has therefore been proposed as a strategy for preventing resistance and improving antitumor activity. We conducted a single-arm phase I study evaluating the combination of ziv-aflibercept, an antiangiogenic drug, with the Hsp90 inhibitor ganetespib.

Methods
Adult patients were eligible if they had recurrent or metastatic gastrointestinal carcinomas, nonsquamous non-small cell lung carcinomas, urothelial carcinomas, or sarcomas that had progressed after at least one line of standard therapy. Ziv-aflibercept was administered intravenously on days 1 and 15, and ganetespib was administered intravenously on days 1, 8, and 15, of each 28-day cycle.

Results
Five patients were treated with the combination. Although three patients achieved stable disease, study treatment was associated with several serious and unexpected adverse events.

Conclusion
The dose escalation phase of this study was not completed, but the limited data obtained suggest that this combination may be too toxic when administered on this dosing schedule.
Applying Bourdieu's field theory to analyze the changing status of the research librarian
Authors: Wien Charlotte Nordahl , Dorch Bertil F. 
Published: May 2018

Research librarians no longer need to perform as many of the traditional chores of the research library. This is due to many factors like digitalization, changing research policies and changes in researchers’ behaviour. With these changes also comes a demand for new skills. We seek an answer to how this demand can be met. We argue that changes that have taken place in the research library have also led to a loss of prestige for the research librarians. We use Bourdieu’s field theory to analyse the power struggles in the academic field and in the field of the research library and to identify means of reclaiming the previous prestigious position in both fields. We end up creating a 60 ECTS framework for a flexible part-time master’s program for research librarians. The first cohort of students has already been enrolled and they evaluate the program in very positive terms.
Is it possible to predict a risk of osteoporosis in patients with juvenile idiopathic arthritis? A study of serum levels of markers of bone turnover
Authors: Janicka-Szczepaniak Marta , Orczyk Krzysztof , Szymbor Katarzyna , Chlebna-Sokół Danuta , Smolewska Elzbieta 
Published: May 2018

Background: Low bone mineral density is a common finding in children with systemic connective tissue diseases, including juvenile idiopathic arthritis (JIA). The influence of the ongoing process of bone remodeling on the disease course merits further investigation. The aim of the study was to assess the clinical relevance of markers of bone turnover and their potential role as predictors of higher fracture risk and, by extension, risk of osteoporosis.Materials and methods: Blood samples were collected from 59 patients diagnosed with JIA in order to determine serum levels of the following markers of bone turnover: Beta-Crosslaps, osteocalcin, bone alkaline phosphatase, osteoprotegerin and receptor activator for nuclear factor kappa-B ligand. The values were analyzed with laboratory parameters and results of dual X-ray absorptiometry (DXA).Results: Osteoprotegerin and bone alkaline phosphatase levels were age-dependent. Beta‑Crosslaps values were significantly higher in patients with positive JADAS27 score (p=0.0410). Osteoprotegerin levels were higher in patients treated with biological agentsthan only withdisease-modifying anti-rheumatic drugs (p=0.0273). There was no relation between markers of bone turnover and sex, DXA results, dosage of glucocorticosteroids and disease duration.Conclusions:Authors postulate performing DXA measurements every 6 months in patients with higher disease activity. The potential lower fracture risk in children with JIA within biological treatment needs future assessment. Age- and sex-adjusted reference rates of markers of bone turnover for Central Europe need to be developed in order to assess individual values properly.
Partial Sternotomy Application in Mediastinal Parathyroid Adenomas
Authors: KATRANCIOĞLU Özgür , ŞAHİN Ekber , KARADAYI Şule 
Published: May 2018

Background:
Solitary parathyroid adenomas are the most common cause of primary
hyperparathyroidism. Generally neck exploration is adequate for parathyroid
adenoma surgery, however some of them aren’t accessible using a
cervical approach and sternotomy or thoracotomy can be required. In this
study we present surgical application of eight cases with mediastinal
parathyroid adenoma. Material
and Methods: Between
Jan 2006 - Mar 2018, eight patients who underwent partial sternotomy for
mediastinal parathyroid adenoma in our clinic were included in the study.
Patients' datas were retrospectively reviewed. Blood tests, radiographic and
scintigraphic methods were performed and the results were reviewed.
Localization of mediastinal
parathyroid adenoma, performed treatment methods and prognosis were
evaluated.Results: Seven of the cases were
female (87.5%) and the mean age was found to be 49.7 years (range: 30-64 years). Bone pain what’s the most
common symptom. All of the patients experienced hypercalcemia and
hyperparathyroidia. PTH and Ca values returned to normal in postoperative period. No recurrent or
consistent hyperparathyroidism was seen during follow-up period. No
postsurgical morbidity or mortality developed.

Conclusion: We claimed
that partial sternotomy is a safe and adequate method for removing ectopic mediastinal parathyroid adenomas.