bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic–Inorganic Hybrid Passivation Enables Perovskite QLEDs with an EQE of 16.48%
Authors: Song Jizhong , Fang Tao , Li Jianhai , Xu Leimeng , Zhang Fengjuan , Han Boning , Shan Qingsong , Zeng Haibo 
Published: October 2018

AbstractPerovskite quantum dots (QDs) with high photoluminescence quantum yields (PLQYs) and narrow emission peak hold promise for next‐generation flexible and high‐definition displays. However, perovskite QD films often suffer from low PLQYs due to the dynamic characteristics between the QD's surface and organic ligands and inefficient electrical transportation resulting from long hydrocarbon organic ligands as highly insulating barrier, which impair the ensuing device performance. Here, a general organic–inorganic hybrid ligand (OIHL) strategy is reported on to passivate perovskite QDs for highly efficient electroluminescent devices. Films based on QDs through OIHLs exhibit enhanced radiative recombination and effective electrical transportation properties compared to the primal QDs. After the OIHL passivation, QD‐based light‐emitting diodes (QLEDs) exhibit a maximum peak external quantum efficiency (EQE) of 16.48%, which is the most efficient electroluminescent device in the field of perovskite‐based LEDs up to date. The proposed OIHL passivation strategy positions perovskite QDs as an extremely promising prospect in future applications of high‐definition displays, high‐quality lightings, as well as solar cells.
Engineering Luminescence Lifetimes of Cu(I) Complexes for Optical Multiplexing
Authors: Ma Yun , Dong Yafang , She Pengfei , Liu Shujuan , Xie Mingjuan , Yu Yaxin , Li Yonghua , Zhao Qiang , Huang Wei 
Published: October 2018

AbstractLuminescent materials with tunable emission lifetimes have gained broad research interest, because they are ideal candidates for optical multiplexing applications, such as biolabeling, security printing, and data storage. To date, a few studies have reported that the efficient regulation of emission decay times can be achieved for lanthanide nanomaterials. However, it remains challenging to engineer the luminescence lifetimes of small molecules due to the lack of effective methods. Herein, a new strategy is put forward to control the emission lifetimes of ionic Cu(I) complexes by changing the electrostatic interactions between cationic complexes and counter anions. The Cu(I) complexes prepared with different counterions (ClO4−, PF6−, NO3−, and BF4−) exhibit distinct luminescence lifetimes from 12.9 to 22.3 µs in the solid state. Importantly, by simply doping different contents of CuBF4 into polymethyl methacrylate, the emission lifetimes could be varied in a linear manner in the range from 11.4 ± 0.3 to 20.7 ± 0.2 µs. Based on the tunable emission lifetimes, optical multiplexing is achieved by using time‐resolved luminescence imaging technique.
All‐Metal‐Organic Framework‐Derived Battery Materials on Carbon Nanotube Fibers for Wearable Energy‐Storage Device
Authors: Zhang Qichong , Zhou Zhenyu , Pan Zhenghui , Sun Juan , He Bing , Li Qiulong , Zhang Ting , Zhao Jingxin , Tang Lei , Zhang Zengxing , Wei Lei , Yao Yagang 
Published: October 2018

AbstractThe ever‐increasing demands for portable and wearable electronics continue to drive the development of high‐performance fiber‐shaped energy‐storage devices. Metal‐organic frameworks (MOFs) with well‐tunable structures and large surface areas hold great potential as precursors and templates to form porous battery materials. However, to date, there are no available reports about fabrication of wearable energy‐storage devices on the utilization of all‐MOF‐derived battery materials directly grown on current collectors. Here, MOF‐derived NiZnCoP nanosheet arrays and spindle‐like α‐Fe2O3 on carbon nanotube fibers are successfully fabricated with impressive electrochemical performance. Furthermore, the resulting all‐solid‐state fiber‐shape aqueous rechargeable batteries take advantage of large specific surface area and abundant reaction sites of well‐designed MOF‐derived electrode materials to yield a remarkable capacity of 0.092 mAh cm−2 and admirable energy density of 30.61 mWh cm−3, as well as superior mechanical flexibility. Thus, this research may open up exciting opportunities for the development of new‐generation wearable aqueous rechargeable batteries.
Cranial Pair II: The Optic Nerves
Authors: Herrera Eloísa , Agudo‐Barriuso Marta , Murcia‐Belmonte Verónica 
Published: October 2018

ABSTRACTThe optic nerves (ONs), one of the 12 pairs of cranial nerves (Pair II), together with the olfactory and the cochlear nerves, are devoted to transmit sensory inputs. In particular, ONs convey visual information from the retina to the brain. In mammals, the ONs are bilateral structures that extend from the optic disc to the optic chiasm containing glial cells and retinal ganglion cells (RGCs) axons. RGCs are the only retinal neurons able to collect visual information and transmit it to the visual centers in the brain for its processing and integration with the rest of sensory inputs. During embryonic development, RGCs born in the retina extend their axons to exit the eye and follow a stereotypic path outlined by the transient expression of a wide set of guidance molecules. As the rest of central nervous system structures, the ONs are covered with myelin produced by oligodendrocytes and wrapped by the meninges. ON injuries or RGCs degenerative conditions may provoke partial or complete blindness because they are incapable of spontaneous regeneration. Here, we first review major advances on the current knowledge about the mechanisms underlying the formation of the ONs in mammals. Then, we discuss some of the human disorders and pathologies affecting the development and function of the ONs and finally we comment on the existing view about ON regeneration possibilities. Anat Rec, 302:428–445, 2019. © 2018 Wiley Periodicals, Inc.
Sliding Mode Control for Markovian Jump Systems with Generalized Switching
Authors: Wang Yanhui , Wang Guoliang , Tong Huiyan 
Published: October 2018

AbstractIn this paper, the sliding mode control (SMC) problem for continuous‐time Markovian jump systems (MJSs) is considered, in which the transition rate matrix (TRM) is partially unknown and uncertain. Firstly, the sliding mode surface S(t) = 0 is designed, which is mode‐dependent. Therefore,
is used instead of
in the SMC algorithm. Via adopting a linear matrix inequality (LMI) approach, sufficient conditions are proposed to ensure that the reduced order system is exponentially stable in mean square. Furthermore, the reduced order system is completely insensitive to the external disturbance. Secondly, SMC law is designed correspondingly which dominated by a Markov process. It could drive the state trajectories onto the specified sliding mode surface in finite time quickly and maintain them on the surface in subsequently time. Thirdly, a new term in
will be introduced in the designed SMC and should be handled by a new approach. Finally, a numerical example is provided to show the effectiveness of the proposed method.
Verhalten von aus Baustoffen ausgelaugten Bioziden bei der Bodenpassage
Authors: Johann Sabine , Schwerd Regina , Scherer Christian R. 
Published: October 2018

AbstractBiozide werden zahlreichen Bauprodukten zum Schutz des Materials vor Bewuchs durch Algen, Pilzen und weitere Mikroorganismen zugesetzt (Filmkonservierung). Damit sie von den Zielorganismen aufgenommen werden können, müssen die Biozide eine gewisse Wasserlöslichkeit besitzen. Diese führt gleichzeitig dazu, dass die Wirkstoffe bei Regenereignissen aus den Bauprodukten ausgelaugt werden und mit dem ablaufenden Regenwasser in den Boden sowie in Grund‐ und Oberflächenwasser gelangen können. Von einigen Bioziden ist zudem bekannt, dass sie in kommunalen Kläranlagen nicht abgebaut werden. Über das Verhalten der Wirkstoffe bei der Bodenpassage liegen derzeit nur wenige Untersuchungen vor. Um eine Aussage über das Verhalten von Bioziden beim Versickern im Boden treffen zu können, wurde die Bodenpassage der Biozide OIT, DCOIT, IPBC, Isoproturon, Terbutryn, Diuron, Carbendazim und Mecoprop‐P mithilfe von Säulenversuchen untersucht. Das Sorptions‐ und Abbauverhalten der Biozide wurde an zwei modellhaften Bodensorten (Quarzsand und Pflanzerde) beobachtet. Die Konzentrationen der betrachteten Biozide sowie deren Transformationsprodukte im Perkolat wurden per Direktinjektion mittels UPLC‐MS/MS bestimmt.
Bauphysikalische und ökologische Potenziale von adaptiven Leichtbaukonstruktionen
Authors: Harder Nadine , Schlegl Friederike , Albrecht Stefan , Park Sumee , Leistner Philip 
Published: October 2018

AbstractDie zunehmende Inanspruchnahme von Ressourcen und die damit einhergehenden Umweltauswirkungen rücken im Bauwesen immer weiter in Vordergrund. Derzeit sind die beiden Disziplinen für etwa 60 % des Ressourcenverbrauchs sowie für etwa 35 % des Energieverbrauchs verantwortlich [1, 2]. Dieser Anteil könnte noch steigen, wenn alle Bauten eine konventionelle Weise verlangen, da die Weltbevölkerung weiter zunimmt. Prognosen gehen von einem Anstieg der Weltbevölkerung bis 2100 von derzeit knapp 7,5 Milliarden auf etwa 11,2 Milliarden Menschen aus [3]. Um der wachsenden Weltbevölkerung sowie der großen Ressourceninanspruchnahme gerecht zu werden, sind innovative, ressourcensparende Leichtbaukonstruktionen unumgänglich. Aktuelle Forschungsarbeiten erweitern das Spektrum hin zu adaptiven Leichtbaukonstruktionen, die es erlauben, bauphysikalische Eigenschaften gezielt anzupassen, um letztlich den extensiven Baustoffeinsatz zu reduzieren. Zur Quantifizierung und Verifizierung der damit verbundenen Potenziale in puncto Nachhaltigkeit wurden die Einflüsse der Adaptivität von Leichtbaukonstruktionen auf deren bauphysikalisches Verhalten sowie deren Ökobilanz erfasst und beschrieben.
Identification of a six‐gene signature with prognostic value for patients with endometrial carcinoma
Authors: Wang Yizi , Ren Fang , Chen Peng , Liu Shuang , Song Zixuan , Ma Xiaoxin 
Published: October 2018

AbstractUterine corpus endometrial carcinoma (UCEC) is frequently diagnosed among women worldwide. However, there are different prognostic outcomes because of heterogeneity. Thus, the aim of the current study was to identify a gene signature that can predict the prognosis of patients with UCEC. UCEC gene expression profiles were first downloaded from the The Cancer Genome Atlas (TCGA) database. After data processing and forward screening, 11 390 key genes were selected. The UCEC samples were randomly divided into training and testing sets. In total, 996 genes with prognostic value were then examined by univariate Cox survival analysis with a P‐value <0.01 in the training set. Next, using robust likelihood‐based survival modeling, we developed a six‐gene signature (CTSW, PCSK4, LRRC8D, TNFRSF18, IHH, and CDKN2A) with a prognostic function in UCEC. A prognostic risk score system was developed by multivariate Cox proportional hazard regression based on this six‐gene signature. According to the Kaplan‐Meier curve, patients in the high‐risk group had significantly poorer overall survival (OS) outcomes than those in the low‐risk group (log‐rank test P‐value <0.0001). This signature was further validated in the testing dataset and the entire TCGA dataset. In conclusion, we conducted an integrated study to develop a six‐gene signature for the prognostic prediction of patients with UCEC. Our findings may provide novel biomarkers for prognosis and have significant implications in the understanding of therapeutic targets for UCEC.
Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma
Authors: Wang Yihong , LeGolvan Mark , Chapin Kimberle , Mainiero Martha 
Published: October 2018

Key Clinical MessageCystic neutrophilic granulomatous mastitis (CNGM) is an increasingly recognized entity in the differential diagnosis of granulomatous inflammation involving the breast. We present the first case report of CNGM mimicking carcinoma of the breast with two mixed bacterial species as the causative pathogens (Corynebacterium and Staphylococcus spp.).
Pillar5arenes as Supramolecular Hosts in Aqueous Biphasic Rhodium‐Catalyzed Hydroformylation of Long Alkyl‐chain Alkenes
Authors: Benatmane Missipssa , Cousin Kévin , Laggoune Nérimel , Menuel Stéphane , Monflier Eric , Woisel Patrice , Hapiot Frédéric , Potier Jonathan 
Published: October 2018

AbstractAqueous biphasic catalysis continues to attract strong interest, especially when very hydrophobic substrates are concerned. Indeed, their insolubility in water strongly limit their transformation by water‐soluble organometallic catalysts. To improve contacts between the substrate‐containing organic phase and the catalyst‐containing phase, one of the best solutions consists in using interfacial additives capable of supramolecularly recognize the substrate and/or the catalyst. In the present study, modified pillar5arenes are considered as interfacial additives and their performance is assessed in Rh‐catalyzed hydroformylation of long alkyl‐chain alkenes (higher olefins). Pillar5arenes substituted by carboxylate functions and methyl groups P5 A‐(Me)10‐x‐(CH2COOMe)x are compared to pillar5arenes substituted by polyethylene glycol (PEG) chains (P5 A‐(Me)5‐(PEG)5 and P5 A‐(PEG)10). Utilization of P5 A‐(Me)10‐x‐(CH2COOMe)x leads to high conversion and regioselectivity (linear/branched aldehyde ratio) in Rh‐catalyzed hydroformylation of 1‐decene and 1‐hexadecene. Compared with other interfacial additives such as modified cyclodextrins, the studied pillar5arenes show lower chemo‐selectivity, similar catalytic activity and higher regioselectivity.
Recovery of nickel and cobalt from nickel laterite leach solution using chelating resins and pre‐reducing process
Authors: Botelho Junior Amilton Barbosa , Espinosa Denise Crocce Romano , Dreisinger David , Tenório Jorge Alberto Soares 
Published: October 2018

AbstractThe aim of this work was to recover nickel and cobalt from a nickel laterite leach solution using chelating resins combined with a pre‐reducing process. Sodium sulphite was used as a reducing agent to convert Fe(II) from Fe(III) and increase adsorption efficiency. Batch experiments were performed using synthetic solutions to study the effect of pH in recovering these metals using chelating resins Lewatit TP 207 and Lewatit TP 220. Column experiments were performed to simulate the fixed‐bed column process in the following two steps: first, removing copper; and second, recovering nickel and cobalt. Two acids were tested as eluent, namely, sulphuric and hydrochloric acid 1M and 2M. Batch experiments showed that increasing the recovery of the metals accompanied an increase in pH. Copper recovery was maximal at pH 2.00, and the resin selectivity changed in pH above 2, decreasing copper adsorption. However, batch experiments showed that nickel and cobalt recovery was higher at pH 3.50, and resin adsorbed a high concentration of contaminants such as iron, zinc, and chromium. For this reason, nickel and cobalt recovery at pH 2.00 was better in column experiments, with less of the contamination in the metals being adsorbed by the resin and a high selectivity for nickel and cobalt. Hydrochloric acid 2M showed to be more efficient as eluent than sulphuric acid. A precipitation process using NaOH was used to remove contaminants present in the eluent solution, and Cyanex 272 was used to separate cobalt and nickel through the solvent extraction process.
NCI 8628: A randomized phase 2 study of ziv‐aflibercept and high‐dose interleukin 2 or high‐dose interleukin 2 alone for inoperable stage III or IV melanoma
Authors: Tarhini Ahmad A. , Frankel Paul , Ruel Christopher , Ernstoff Marc S. , Kuzel Timothy M. , Logan Theodore F. , Khushalani Nikhil I. , Tawbi Hussein A. , Margolin Kim A. , Awasthi Sanjay , Butterfield Lisa H. , McDermott David , Chen Alice , Lara Primo N. , Kirkwood John M. 
Published: October 2018

AbstractBackgroundInterleukin 2 (IL‐2) is a growth factor for T and natural killer cells, promotes proinflammatory cytokines, and can lead to durable responses in patients with melanoma. Vascular endothelial growth factor (VEGF) promotes angiogenesis and modulates host innate and adaptive immunity. High VEGF levels were found to be associated with nonresponse to IL‐2. Ziv‐aflibercept may deplete VEGF and thereby enhance antitumor T‐cell responses, thus supporting a combination immunotherapeutic strategy with IL‐2.MethodsNCI 8628 was a phase 2 trial of ziv‐aflibercept and IL‐2 (arm A) versus IL‐2 alone (arm B) randomized at 2:1, respectively. Eligible patients had inoperable American Joint Committee on Cancer stage III or stage IV melanoma. The primary endpoint was progression‐free survival (PFS).ResultsA total of 89 patients were enrolled and 84 patients were treated. The median follow‐up was 41.4 months. Among treated patients (55 patients in arm A and 29 patients in arm B), PFS was significantly improved in favor of arm A, with a median of 6.9 months (95% confidence interval [95% CI], 4.1‐8.7 months) versus 2.3 months (95% CI, 1.6‐3.5 months) (P<.001). No significant difference was noted with regard to overall survival, with a median of 26.9 months (95% CI, 14.4‐63.6 months) for arm A and 24.2 months (95% CI, 11.3‐36.4 months) for arm B. The response rate (according to Response Evaluation Criteria In Solid Tumors [RECIST]) was 22% in arm A (4 complete responses [CRs] and 8 partial responses [PRs]) and 17% in arm B (1 CR and 4 PRs). Stable disease or PR or CR was noted in 65% of patients in arm A and 48% of patients in arm B. The combination was found to be superior to monotherapy in patients with high and low levels of serum VEGF and VEGF receptor 2. Adverse events were consistent with the expected profiles of monotherapy with IL‐2 and ziv‐aflibercept.ConclusionsZiv‐aflibercept and IL‐2 were found to significantly improve PFS compared with IL‐2 alone, thereby meeting the primary endpoint of the current study. These findings support further study of immunotherapeutic combination strategies involving VEGF inhibitors.
Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study
Authors: Hahn David , Emoto Chie , Euteneuer Joshua C. , Mizuno Tomoyuki , Vinks Alexander A. , Fukuda Tsuyoshi 
Published: October 2018

Morphine is commonly used for analgesia in the neonatal intensive care unit (NICU) despite having highly variable pharmacokinetics (PKs) between individual patients. The pharmacogenetic (PG) effect of variants at the loci of organic cation transporter 1 (OCT1) and UDP‐glucuronosyltransferase 2B7 (UGT2B7) on age‐dependent morphine clearance were evaluated in a cohort of critically ill neonatal patients using an opportunistic sampling design. Our primary results demonstrate the significant influence of OCT1 genotype (P < 0.05) and gestational age (P ≤ 0.005) on morphine PKs. A physiologically based pharmacokinetic (PBPK) model for morphine that accounted for OCT1 ontogeny and PG effect in post‐term neonates adequately described the clinically observed variability in morphine PKs. This study serves as a proof of concept for genotype‐dependent drug transporter ontogeny in neonates.
High‐Voltage and Low‐Temperature Aqueous Supercapacitor Enabled by “Water‐in‐Imidazolium Chloride” Electrolytes
Authors: Tatlisu Ammar , Huang Zhifeng , Chen Ruiyong 
Published: October 2018

AbstractSymmetric aqueous high voltage supercapacitors up to 3 V have been demonstrated using concentrated aqueous 1‐butyl‐3‐methylimidazolium chloride ([BMIm]Cl), namely, “water‐in‐imidazolium chloride”, as working electrolytes, and graphene nanoplatelets‐coated carbon paper as electrodes. Performance enhancement was further achieved either through adding redox species such as 4‐hydroxy‐2,2,6,6‐tetramethylpiperidin‐1‐oxyl (4hT) into the electrolytes (110 Wh kg−1 for a 20 m [BMIm]Cl/H2O with 0.1 m 4hT) or by pre‐inserting ClO4− anions into the graphene platelets. Moreover, the newly studied aqueous electrolytes allow low‐temperature operation at −20 °C and even at −32 °C, retaining competitive energy storage capability (maximum energy densities of 36 and 21 Wh kg−1, respectively).
A metabarcoding approach for the feeding habits of European hake in the Adriatic Sea
Authors: Riccioni Giulia , Stagioni Marco , Piccinetti Corrado , Libralato Simone 
Published: October 2018

AbstractEuropean hake (Merluccius merluccius) is one of the most economically important fish for the Mediterranean Sea. It is an important predator of deep upper shelf slope communities currently characterized by growth overexploitation: the understanding of hake's diet might support next generation management tools. However, all current European hake diet studies depend on the morphological identification of prey remains in stomach content, with consequent limitations. In this study, we set up a metabarcoding approach based on cytochrome oxidase I PCR amplification and Miseq Illumina paired‐end sequencing of M. merluccius stomach content remains and compared the results to classic morphological analyses. A total of 95 stomach contents of M. merluccius sampled in the North‐Central Adriatic Sea were analyzed with both the metabarcoding and morphological approaches. Metabarcoding clearly outperformed the morphological method in the taxonomic identification of prey describing more complex trophic relationships even when considering the morphological identification of 200 stomach contents. Statistical analysis of diet composition revealed a weak differentiation among the hake's size classes, confirming an opportunistic feeding behavior. All the analyses performed showed the presence of a core of shared prey among the size classes and a cloud of size‐specific prey. Our study highlights the exceptional potential of metabarcoding as an approach to provide unprecedented taxonomic resolution in the diet of M. merluccius and potentially of other marine predators, due to the broad‐spectrum of detection of the primers used. A thorough description of these complex trophic relationships is fundamental for the implementation of an ecosystem approach to fisheries.
Evaluating ecohydrological modelling framework to link atmospheric CO2 and stomatal conductance
Authors: Lu Xuefei , Wang Lixin 
Published: October 2018

AbstractThe establishment of an accurate stomatal conductance (gs) model in responding to CO2 enrichment under diverse environmental conditions remains an important issue as gs is the key to understand the plant–water–atmosphere interactions. A better representation of gs is important to reduce uncertainties in predicting the climate change impacts on various ecosystem functions. In this study, we evaluated three most commonly used gs formulations for the estimation of the stomatal response to environmental factors using in situ measurements under different environmental conditions. The three gs models were Leuning's modified Ball–Berry model and two specific cases of the optimization models (i.e., Rubisco limitation model and RuBP regeneration limitation model). On the basis of an analysis of 234 data points obtained from experiments under instantaneous, semicontrolled, and the free‐air CO2 experiment conditions, we found that Leuning's modified Ball–Berry model and RuBP‐limited optimization model showed similar performance, and both performed better than Rubisco limitation model. Functional groups (e.g., C3 vs. C4 species) and life form (e.g., annual vs. perennial species) play an important role in determining the gs model performance and thus pose a challenge for gs predictions in mixed vegetation communities.