bluuebunny/crossref_metadata_2025_split huggingface dataset:
Woodlands, Warlords, and Wasteful Nations: Transnational Networks and Conservation Science in 1920s China
Authors: Muscolino Micah S. 
Published: June 2019

AbstractThis article investigates the production of conservation science at nodes of transnational networks of encounter through an examination of field studies conducted during the mid-1920s in North China's Shanxi province by the American forester and soil conservation expert Walter C. Lowdermilk with his student, colleague, and collaborator Ren Chengtong. Even in the politically fragmented China of the 1920s, their research on deforestation, streamflow, and erosion benefited from alliances with Shanxi's regional powerholder, Yan Xishan, and produced environmental knowledge that furthered the agenda of harnessing natural resources to strengthen the state. By paying attention to two-way interactions between Chinese and foreign actors in the construction and transmission of knowledge about nature, the article speaks to the global context of the early twentieth-century conservation movement and adds to recent scholarship that recasts China's encounter with modern science as one of active appropriation, translation, and innovation rather than passive reception.
The Invention of Neo-Socialism: The Dynamics of Schism and Doctrinal Distinction in the French Socialist Party
Authors: Desan Mathieu Hikaru 
Published: June 2019

AbstractWhat is the relationship between schism and political identity? Existing scholarship has tended to focus on the determinants of schism while treating the ideational basis on which schisms are made as largely fixed. In this paper, I develop a new interpretation of the 1933 “neo-socialist schism” within the French Socialist Party to highlight how new political identities can be constituted in and through the process of schism itself. The 1933 schism is often understood as the convergence of a doctrinal revision called “neo-socialism” and a separate tactical challenge to the party's parliamentary practice. But a careful reading of the factional conflict within the party reveals that it was the preceding tactical debate over ministerial participation that was transformed over time into a debate over socialist doctrine. This distinction between “tactics” and “doctrine” performatively defined the limits of acceptable party discourse, and as such was both a weapon and a stake in the factional conflict. I trace the evolution of this conflict and show that, so long as the minority faction was weak, the issue of participation was widely considered “tactical” and thus safe for discussion. But when minority strength grew, the majority sought to redefine the conflict as doctrinal to delegitimate the challengers. Finally, only when a schism appeared inevitable did the challengers themselves adopt the label of “neo-socialism.” Neo-socialism was thus not a pre-constituted political heresy driving the schismatic process, but the contingent and emergent outcome of this very process.
Statutory Reform of the Doctrine of Uberrimae Fidei in Insurance Law: A Comparative Review
Authors: Anifalaje Kehinde 
Published: June 2019

AbstractThe common law doctrine of uberrimae fidei is pivotal to all contracts of insurance. It imposes a duty on the parties to act towards each other with utmost good faith by disclosing all material facts and not misrepresenting any fact, either before the contract is formed or while the contract subsists. This article examines the doctrine and its statutory reforms in Nigeria and the United Kingdom. It argues that, before the statutory interventions, the iniquitous doctrine was a potent weapon, most often used by insurers to defeat just and legitimate claims by an insured. Although the legislation has brought some measure of relief to the insured in these jurisdictions, the article concludes that there are still some grey areas in the Nigerian law that need to be addressed to further the cause of justice between the contracting parties.
Mood fluctuation in Antarctic expeditioners: does one size fit all?
Authors: Hawkes Clare , Norris Kimberley , Ayton Jeff , Paton Douglas 
Published: June 2019

AbstractIt has long been argued that mood fluctuation patterns in Antarctic expeditioners are largely homogeneous. This research investigated mood fluctuation patterns throughout all the stages of Antarctic deployment using latent class growth analysis. Utilising advanced statistical methods, such as latent class growth analysis, can greatly help in identifying if mood fluctuation patterns experienced by Antarctic expeditioners are homogenous, and provide insight into mood fluctuation patterns, which was not possible with traditional group-based quantitative methods. Gaining a greater insight into mood fluctuation patterns in Antarctic expeditioners can assist with the development, and implementation of, strategies to assist with expeditioner well-being. The analysis was conducted on 423 expeditioner from the Australian Antarctic program between the 2005-2009 Antarctic deployment seasons. The results supported the notion that mood fluctuation patterns in expeditioners within the Australian-Antarctic programme were largely homogeneous, as a 1-class cubic latent class growth model was identified as being the optimal fit for the dataset. Theoretical and practical implications are discussed in relation to research and prevention and intervention strategies.
Comparison of the epidemiological aspects of acute infectious diseases between foreign and native imported cases in the border counties of Southwest China, 2008–2017
Authors: Jiang Li , Huang Tian 
Published: June 2019

Abstract
This study analysed the epidemiological characteristics of imported cases of acute infectious diseases and compared these features by nationality in 25 border counties of Yunnan Province from 2008 to 2017 to inform prevention strategies. Surveillance data for the imported cases collected in the border counties were analysed to determine disease variety, seasonal patterns, infection site and personal demographics and these features were compared by patient nationality. A total of 12 820 imported cases were reported in the 25 border counties, with 5610 foreign cases and 7210 native cases. The disease spectrum was more diverse among foreign cases than among native cases. Both foreign and native cases were mostly imported from Myanmar. The shift in the number of foreign cases was greater than that of native cases after 2016. Ruili, a city, that shares a border with Myanmar, exhibited the greatest number of imported infections. Farmers, businessmen, women and preschool children were frequently diagnosed with infections. Multiple prevention strategies including disease screening at the border, health education before departure and health service provision to foreigners should be carried out to reduce the risk of autochthonous spreading and to avoid potential outbreaks. Furthermore, international collaboration in terms of sharing infectious disease data should be improved between China and neighbouring countries.
The Multilingual Naming Test (MINT) as a Measure of Picture Naming Ability in Alzheimer’s Disease
Authors: Stasenko Alena , Jacobs Diane M. , Salmon David P. , Gollan Tamar H. 
Published: June 2019

AbstractObjective:The present study investigated the ability of the Multilingual Naming Test (MINT), a picture naming test recently added to the National Alzheimer’s Coordinating Center’s (NACC) Uniform Data Set neuropsychological test battery, to detect naming impairment (i.e., dysnomia) across stages of Alzheimer’s disease (AD).Method:Data from the initial administration of the MINT were obtained on NACC participants who were cognitively normal (N= 3,981) or diagnosed with mild cognitive impairment (N= 852) or dementia (N= 1,148) with presumed etiology of AD. Dementia severity was rated using the Clinical Dementia Rating (CDR) scale.Results:Cross-sectional multiple regression analyses revealed significant effects of diagnostic group, sex, education, age, and race on naming scores. Planned comparisons collapsing across age and education groups revealed significant group differences in naming scores across levels of dementia severity. ROC curve analyses showed good diagnostic accuracy of MINT scores for distinguishing cognitively normal controls from AD dementia, but not from MCI. Within the cognitively normal group, there was a robust interaction between age and education such that naming scores exhibited the most precipitous drop across age groups for the least educated participants. Additionally, education effects were stronger in African-Americans than in Whites (a race-by-education interaction), and race effects were stronger in older than in younger age groups (a race-by-age interaction).Conclusions:The MINT successfully detects naming deficits at different levels of cognitive impairment in patients with MCI or AD dementia, but comparison to age, sex, race, and education-corrected norms to determine impairment is essential.
Economics of climate change: introducing the Basic Climate Economic (BCE) model
Authors: Bretschger Lucas , Karydas Christos 
Published: June 2019

AbstractEnvironmental economics models are often too complex to be communicated in an illustrative manner. For this reason, this paper develops the Basic Climate Economic (BCE) model that features core elements of macroeconomic and climate economic modelling, while allowing for an illustrative examination of the development path. The BCE model incorporates fossil stock depletion, pollution stock accumulation, endogenous growth, and climate-induced capital depreciation. We first use graphical analysis to show the effects of climate change and climate policy on economic development. Intuition for the different model mechanisms, the functional forms, and the effects of different climate policies is provided. We then show the model equations in mathematical terms to derive closed-form solutions and to run model simulations relating to the graphical part. Finally, we compare our setup to other models of climate economics.
How Intelligence Affects Fertility 30 Years On: Retherford and Sewell Revisited — With Polygenic Scores and Numbers of Grandchildren
Authors: Woodley of Menie Michael A. , Rindermann Heiner , Pallesen Jonatan , Sarraf Matthew A. 
Published: June 2019

AbstractUsing newly available polygenic scores for educational attainment and cognitive ability, this paper investigates the possible presence and causes of a negative association between IQ and fertility in the Wisconsin Longitudinal Study sample, an issue that Retherford and Sewell first addressed 30 years ago. The effect of the polygenic score on the sample’s reproductive characteristics was indirect: a latent cognitive ability measure, comprised of both educational attainment and IQ, wholly mediated the relationship. Age at first birth mediated the negative effect of cognitive ability on sample fertility, which had a direct (positive) effect on the number of grandchildren. Significantly greater impacts of cognitive ability on the sample’s fertility characteristics were found among the female subsample. This indicates that, in this sample, having a genetic disposition toward higher cognitive ability does not directly reduce number of offspring; instead, higher cognitive ability is a risk factor for prolonging reproductive debut, which, especially for women, reduces the fertility window and, thus, the number of children and grandchildren that can be produced. By estimating the effect of the sample’s reproductive characteristics on the strength of polygenic selection, it was found that the genetic variance component of IQ should be declining at a rate between −.208 (95% CI [−.020, −.383]) and −.424 (95% CI [−.041, −.766]) points per decade, depending on whether GCTA-GREML or classical behavior genetic estimates of IQ heritability are used to correct for ‘missing’ heritability.
Genetic Contributions to Health Literacy
Authors: Fawns-Ritchie Chloe , Davies Gail , Hagenaars Saskia P. , Deary Ian J. 
Published: June 2019

AbstractHigher health literacy is associated with higher cognitive function and better health. Despite its wide use in medical research, no study has investigated the genetic contributions to health literacy. Using 5783 English Longitudinal Study of Ageing (ELSA) participants (mean age = 65.49,SD= 9.55) who had genotyping data and had completed a health literacy test at wave 2 (2004–2005), we carried out a genome-wide association study (GWAS) of health literacy. We estimated the proportion of variance in health literacy explained by all common single nucleotide polymorphisms (SNPs). Polygenic profile scores were calculated using summary statistics from GWAS of 21 cognitive and health measures. Logistic regression was used to test whether polygenic scores for cognitive and health-related traits were associated with having adequate, compared to limited, health literacy. No SNPs achieved genome-wide significance for association with health literacy. The proportion of variance in health literacy accounted for by common SNPs was 8.5% (SE= 7.2%). Greater odds of having adequate health literacy were associated with a 1 standard deviation higher polygenic score for general cognitive ability [OR= 1.34, 95% CI (1.26, 1.42)], verbal-numerical reasoning [OR= 1.30, 95% CI (1.23, 1.39)], and years of schooling [OR= 1.29, 95% CI (1.21, 1.36)]. Reduced odds of having adequate health literacy were associated with higher polygenic profiles for poorer self-rated health [OR= 0.92, 95% CI (0.87, 0.98)] and schizophrenia [OR= 0.91, 95% CI (0.85, 0.96)). The well-documented associations between health literacy, cognitive function and health may partly be due to shared genetic etiology. Larger studies are required to obtain accurate estimates of SNP-based heritability and to discover specific health literacy-associated genetic variants.
Single‐Site IPS Power Spectra Analysis for Space Weather Products Using Cross‐Correlation Function Results From EISCAT and MERLIN IPS Data
Authors: Chang O. , Bisi M. M. , Aguilar‐Rodriguez E. , Fallows R. A. , Gonzalez‐Esparza J. A. , Chashei I. , Tyul'bashev S. 
Published: June 2019

AbstractInterplanetary scintillation (IPS) manifests itself as a variation in the radio signal received from a distant, compact radio source on the sky. The intensity fluctuations of the radio waves are caused by density inhomogeneities in the outflowing solar plasma across the heliosphere. IPS allows us to infer solar wind speed and density variations along the line of sight. There are two types of techniques in the literature to infer solar wind speed using IPS data sets: single‐site analysis (SSA), where the power spectra from single time series are analyzed to obtain solar wind parameters, and multisite analysis, where the cross‐correlation function of data from two or more widely separated sites is used. The selection of the analysis technique depends on the number of sites available to each IPS system. In order to combine and complement solar wind speed determinations from different instruments, it is important to validate results and methodologies of the two techniques. In this paper, we analyzed previously well‐studied European Incoherent SCATter (EISCAT) and Multi‐Element Radio‐Linked Interferometer Network (MERLIN) observations of IPS with well‐known results from the cross‐correlation function methodology. We applied the SSA technique to each of the individual EISCAT and MERLIN IPS power spectra. This work shows the capabilities of the SSA to describe complex events and seeks to obtain improved parameter fits using the SSA methodology.
Whistler Waves in the Plasmasphere Boundary Layer: Nonlinear Parametric Excitation
Authors: Mishin Evgeny , Sotnikov Vladimir , Gershenzon Naum , Sharma Amit 
Published: June 2019

AbstractWe present the initial results of numerical simulations of nonlinear coupling between quasi‐electrostatic lower hybrid oblique resonance and fast magnetosonic waves, which was suggested to explain the observations of Very Low Frequency (VLF) electromagnetic emissions at frequencies well above the lower hybrid resonance frequency in the turbulent plasmasphere boundary layer. These emissions represent a distinctive subset of the substorm/storm‐related VLF whistler activity contributing to the alteration of the outer radiation belt boundary. As the turbulent plasmasphere boundary layer is interior to the plasma sheet inner boundary and thus devoid of substorm‐injected kiloelectron volt electrons, the “standard” whistler generation mechanism must be excluded. The simulations show that the parametric coupling of lower hybrid oblique resonance and magnetosonic waves creates VLF electromagnetic emissions with the spectral characteristics consistent with the observations.
Wave Field Propagation in Extended Highly Anisotropic Media
Authors: Rino Charles , Carrano Charles , Groves Keith 
Published: June 2019

AbstractThe theory propagation in the Earth's ionosphere is well established. However, with the advent of Global Navigation Satellite System measurements, new demands are being placed on satellite system performance evaluation and diagnostic measurements. Propagation simulations are essential for system performance evaluation and they provide guidelines for interpreting diagnostic measurements. This paper presents simulations of propagation in extended highly anisotropic media obtained with split‐step integration of the parabolic wave equation. This requires three‐dimensional realizations of the electron density structure. A new configuration‐space model is used to generate realizations as summations of striations, which are local to field lines with defined scales and peak densities. The scale and peak densities can be selected to generate specified power law spectral density functions. An analytic three‐dimensional expectation spectral density function provides a parameterized ionospheric structure model. The simulations results show that replacing the extended structure with an equivalent phase screen placed at the center of the structured region provides statistically equivalent realizations of observation‐plane measurements at propagation distances greater than the layer extent. The equivalence is independent of the propagation direction relative to the magnetic field direction, although there is some variation for the extreme propagation disturbances caused by field‐aligned propagation. We also investigate the interpretation of in situ and path‐integrated diagnostic measurements and two‐dimensional propagation models, which are being used to model diagnostic measurements directly.
Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells
Authors: Wolf Benita , Busso Coralie , Gönczy Pierre 
Published: June 2019

AbstractProper spindle positioning is crucial for spatial cell division control. Spindle positioning in human cells relies on a ternary complex comprising Gαi1–3, LGN and NuMA, which anchors dynein at the cell cortex, thus enabling pulling forces to be exerted on astral microtubules. We develop a live imaging siRNA-based screen using stereotyped fibronectin micropatterns to uncover components modulating spindle positioning in human cells, testing 1280 genes, including all kinases and phosphatases. We thus discover 16 components whose inactivation dramatically perturbs spindle positioning, including tyrosine receptor kinase 3 (TYRO3) and cyclin G associated kinase (GAK). TYRO3 depletion results in excess NuMA and dynein at the cortex during metaphase, similar to the effect of blocking the TYRO3 downstream target phosphatidylinositol 3-kinase (PI3K). Furthermore, depletion of GAK leads to impaired astral microtubules, similar to the effect of downregulating the GAK-interactor Clathrin. Overall, our work uncovers components and mechanisms governing spindle positioning in human cells.
Does splitting sleep improve long-term memory in chronically sleep deprived adolescents?
Authors: Cousins James N. , van Rijn Elaine , Ong Ju Lynn , Wong Kian F. , Chee Michael W. L. 
Published: June 2019

AbstractSleep aids the encoding and consolidation of declarative memories, but many adolescents do not obtain the recommended amount of sleep each night. After a normal night of sleep, there is abundant evidence that a daytime nap enhances the consolidation of material learned before sleep and also improves the encoding of new information upon waking. However, it remains unclear how learning is affected when sleep is split between nocturnal and daytime nap periods during a typical school week of restricted sleep. We compared long-term memory in 58 adolescents who underwent two simulated school weeks of suboptimal continuous (6.5 h nocturnal sleep opportunity) or split sleep (5 h nocturnal sleep +1.5 h daytime nap at 14:00). In the first week, participants encoded pictures in the late afternoon on Day 5 and were tested after 2-nights of recovery sleep. On 3 consecutive days in the second week, participants learned about six species of amphibians in the morning, and six different amphibians in the late afternoon. Testing was performed in the evening following a night of recovery sleep. In the first week, the split sleep group recognized more pictures. In the second week, they remembered more facts about species learned in the afternoon. Groups did not differ for species learned in the morning. This suggests that under conditions of sleep restriction, a split sleep schedule benefits learning after a nap opportunity without impairing morning learning, despite less preceding nocturnal sleep. While not replacing adequate nocturnal sleep, a split sleep schedule may be beneficial for chronically sleep restricted learners.
Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
Authors: Kamagata Kiyoto , Mano Eriko , Itoh Yuji , Wakamoto Takuro , Kitahara Ryo , Kanbayashi Saori , Takahashi Hiroto , Murata Agato , Kameda Tomoshi 
Published: June 2019

AbstractIntrinsically disordered regions (IDRs) of proteins are involved in many diseases. The rational drug design against disease-mediating proteins is often based on the 3D structure; however, the flexible structure of IDRs hinders the use of such structure-based design methods. Here, we developed a rational design method to obtain a peptide that can bind an IDR using only sequence information based on the statistical contact energy of amino acid pairs. We applied the method to the disordered C-terminal domain of the tumor suppressor p53. Titration experiments revealed that one of the designed peptides, DP6, has a druggable affinity of ~1 μM to the p53 C-terminal domain. NMR spectroscopy and molecular dynamics simulation revealed that DP6 selectively binds to the vicinity of the target sequence in the C-terminal domain of p53. DP6 inhibits the nonspecific DNA binding of a tetrameric form of the p53 C-terminal domain, but does not significantly affect the specific DNA binding of a tetrameric form of the p53 core domain. Single-molecule measurements revealed that DP6 retards the 1D sliding of p53 along DNA, implying modulation of the target searching of p53. Statistical potential-based design may be useful in designing peptides that target IDRs for therapeutic purposes.