bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a Video Education Program Regarding Basic Skin Care in Pediatric Atopic Dermatitis: A Randomized Controlled Trial
Authors: Jungwattanavanit Pornthip , Wananukul Siriwan , Tempark Therdpong , Chantawarangul Karaked , Chatproedprai Susheera 
Published: November 2024

ABSTRACTBackgroundBasic skin care education holds the potential to improve clinical outcomes in pediatric atopic dermatitis (AD). However, evidence is lacking on the efficacy of video education for patient guardians in Thailand to reduce AD disease severity.ObjectivesTo compare the efficacy of a video education program for guardians of pediatric AD patients versus a control group by assessing the severity score of AD (SCORAD), transepidermal water loss (TEWL), and skin hydration (SH).MethodsA single‐blinded, randomized controlled trial was conducted at a tertiary hospital from June 2023 to February 2024, involving AD patients aged < 18 years and their guardians. Both groups received standard treatment, and the educational group received an additional video education program. SCORAD, TEWL, SH, pruritus, sleeplessness, and parental/guardian confidence and knowledge accuracy were assessed at enrollment and a 4‐week follow‐up.ResultsSeventy patients (educational:control group, 34:36) with a median age of 3.1 years were enrolled. The groups exhibited no significant demographic or disease severity differences between them. At follow‐up, the educational group showed significant SCORAD improvement compared to the control group (mean difference −10.93 [95% CI −16.92–−4.95]; p < 0.001). SH (mean difference 3.82 [95% CI −2.7–10.33]; p = 0.25) and TEWL (mean difference −1.24 [95% CI −5.72–3.24]; p = 0.58) did not differ significantly.ConclusionsVideo education demonstrated efficacy in significantly reducing SCORAD. While there were improvements in SH and TEWL in patients in the education group, these improvements were not statistically significant. Further investigation with a larger sample size is warranted.Trial Registration: Thai Clinical Trials Registry (TCTR): TCTR20230524001
The Effect of Mobile Application Follow‐Up on Treatment Compliance and Self‐Care Management in Patients With Hypertension: Randomized Controlled Trial
Authors: Yildirim Keskin Alev , Özpancar Şolpan Nurhan , Değirmenci Hasan 
Published: November 2024

ABSTRACTBackgroundHypertension (HT) is a global health problem. Although there are effective treatment protocols, patients have difficulty in adapting to regular use of drugs, diet, and lifestyle changes. Mobile apps can be a potential alternative for managing HT and improving self‐care behavior.PurposeThis study aimed to determine the effect of mobile application follow‐up on treatment compliance and self‐care management in patients with HT.MethodsThis randomized controlled trial was conducted in November 2021 and March 2022 with 40 experimental and 40 control group patients with HT. Research data were collected using a patient information form, “Hill‐Bone Hypertension Treatment Compliance Scale (HBHTTCS),” “Hypertension Self‐Care Profile‐Motivation Scale (HTSPMS),” a mobile application program (daily blood pressure, pulse, medication, diet, exercise tracking) uploaded to the mobile phones of the patients, and individual motivational messages.ResultsThe mean total score of the HBHTTCS at Week 6 was 14.57 ± 1.89 and the mean total score of the HTSPMS was 78.15 ± 2.05. There was a statistically significant difference in mean total HTSPMS (p = 0.000) and HBHTTCS (p = 0.000) scores and mean scores on medical (p = 0.002) and nutrition (p = 0.002) subscales of HBHTTCS between the first interview (1st‐week follow‐up) and the last interview (6th‐week follow‐up) of patients in the intervention group.ConclusionsThis study showed that mobile application follow‐up increased motivation levels and treatment compliance in patients with HT and resulted in better self‐care. These positive findings indicate importance of integrating mobile applications in the disease management of HT patients.Trial RegistrationClinicalTrials.gov ID: NCT05334446, https://clinicaltrials.gov/ct2/show/NCT05334446.
European approaches to wastewater reuse regulation: A comparison between Spain, Malta and the Netherlands
Authors: Melchers Sophie 
Published: November 2024

AbstractWastewater reuse is encouraged and facilitated by legislation and policy across the EU. A recent example is the EU Regulation 2020/741 on minimum requirements for water reuse. This and other regulatory developments have gone hand in hand with an increase in research in technological innovations that facilitate wastewater reuse, including advanced water treatment technologies. Despite these harmonised developments at the EU level, there appear to be large differences across Member States in the volume of reused water, its sources and the purposes of wastewater reuse. These differences are mirrored in the differences in the regulation of wastewater reuse across the European Union. The present paper has two goals. The first is to provide an overview of the regulation of wastewater reuse in three EU Member States, namely, Spain, Malta and the Netherlands. The comparative analysis reveals evidence of variability in the division of roles and responsibilities, substantive provisions on water reuse, and the allocation of costs. The second objective of the paper is to highlight how, even within the boundaries of the theoretical best practices, national regulation can be heterogenous.
Children's consideration of effort and outcome in reward distribution tasks
Authors: Kim Emily , LoBue Vanessa 
Published: November 2024

AbstractIn the current study, we asked whether children recognize initial inequalities in resources and the effect of these inequalities on subsequent outcomes. We presented 6‐ to 8‐year‐old children with a series of vignettes in which characters’ contribution and effort to a joint task were manipulated, along with the tool they had to complete the task, which affected their relative advantage. Each vignette contained a situation where two children had to help a third person dig pails of sand. In each scenario, the number of pails each child dug, as well as the type of shovel (making it easier or harder for them to dig), was manipulated. Children were asked how rewards should be distributed and who they believed worked harder. We found that children weighed outcome, or the number of pails of sand produced, more heavily than other factors, and only the oldest children showed evidence of considering initial inequalities and effort when making decisions about resource allocation.
Beyond coalition and opposition? The effect of councilwide agreements on legislative voting behaviour in Dutch municipalities
Authors: Vos Thijs , Otjes Simon , van Kalken Lianne , Boogaard Geerten 
Published: November 2024

AbstractA well‐established finding in the field of legislative behaviour is that parliamentary voting behaviour is nearly always strongly structured by the coalition‐opposition dynamic, even beyond the issues agreed on in the coalition agreement. Can parties break the mould of this coalition‐opposition division? Several Dutch municipal councils work with a councilwide agreement (raadsakkoord) with the specific goal that there is no demarcated coalition and opposition. This could open the political process up for more issue‐driven voting. We test whether council agreements change voting behaviour in the local council. By comparing voting in these municipalities before and after implementing councilwide agreements, we show that these agreements lower the extent to which voting is structured by the coalition‐opposition division. Coalition parties are less likely to vote the same when a councilwide agreement is present. The strength of the coalition‐opposition division depends upon the choices of political parties.
Direct Observations of Intergenerational Visits and Activities at Six Local Recreational Parks in Victoria, Australia
Authors: Levinger Pazit , Dreher Bronwyn , Fearn Marcia , Bauman Adrian , Brusco Natasha K. , Gilbert Andrew , Soh Sze-Ee , Burton Elissa , Hallissey Mairead , Hill Keith D. 
Published: November 2024

Local parks offer outdoor spaces for active play; they provide a common attractive space in which grandparents and grandchildren can interact and engage in physical activity. This study investigated how multigenerational active spaces within local parks were being used by older people, their grandchildren, and other age groups. Method: This study was an observational design using direct observations of park visitors over three consecutive months and an intercept survey of a subsample of older visitors in six community parks in Victoria, Australia. The number of visitors, activity interaction, type of accompaniment (e.g., intergenerational, family, group), and physical activity level were recorded and reported descriptively. Results: A total of 5,373 visitors were observed with 43.3% (n = 2,327) children and 10% (n = 537) older people. Most visitors attended with company (55.9%–97.7%), with older people’s most common accompaniments being intergenerational groups (n = 164, 30.5%). Within the observed intergenerational instances, 35% were older people and 45.1% children. Most people from all age groups were observed to be physically active (≥78%). Survey respondents (n = 48) reported attending the park alone (47.9%) or with company (e.g., 22.9% grandchildren, 12.5% a partner/friend). Approximately a third of respondents reported exercising with their grandchildren in the designated space. Discussion: A large proportion of older visitors were observed with intergenerational accompaniment in local parks, with most grandparents and their grandchildren observed to be physically active. The active spaces, which include multigenerational outdoor equipment, may be an attractive setting for both children and older adults to foster intergenerational interaction and engagement in physical activity.
Social and Emotional Learning in Finnish Physical Education Teacher Education
Authors: Mäkinen Tommi , Virtanen Anne , Kostiainen Emma 
Published: November 2024

Purpose: Teachers’ social and emotional learning (SEL) skills play a central role in physical education to promote holistic youth development and physical activity. The purpose of this study was to explore what SEL skills Finnish physical education student teachers learned during their final study year at university and how they described the meaning of SEL in part of their teacherhood. Method: Data were collected from a questionnaire for four annual courses of Finnish physical education student teachers (n125) and written teaching philosophies (n12). Results: Students reported learning many different SEL skills during their final year. Most learning experiences were reported in self-awareness skills and relationships skills. SEL was also described as (a) a tool for better teaching, (b) a basis for human perception, and (c) changing the way they view their teacherhood. Discussion/Conclusion: The findings indicated that students place a high value on learning SEL skills and that SEL is central to their overall view of physical education.
Oncologic outcomes of incidental serous tubal intraepithelial carcinoma and associated high-grade serous carcinoma in high-risk patients undergoing risk-reducing surgery
Authors: Aoun Eliane , Lawson Barrett , Awujo Chika , Nebgen Denise , Soletsky Beth R , Chisholm Gary B , Lu Karen H , Nitecki Wilke Roni 
Published: November 2024

ObjectiveWe sought to describe the oncologic outcomes of isolated serous tubal intraepithelial carcinomas compared to an intraepithelial carcinoma found concurrently with microscopic high-grade serous carcinoma among patients with hereditary predisposition to ovarian cancer who underwent risk-reducing surgery.MethodsWe conducted a retrospective analysis of 32 high-risk patients withBRCA1, BRCA2, RAD51C/D, BRIP1,orPALB2pathogenic variants who were diagnosed with either isolated serous tubal intraepithelial carcinoma or concurrent serous tubal intraepithelial carcinoma and microscopic high-grade serous carcinoma following risk-reducing surgery between January 2006 and December 2023. Our population included patients who underwent surgery at our institution as well as those who had surgery elsewhere, but sought second opinions, follow-up care, or treatment at our institution. Data were gathered from medical and pathologic records, and pathologic specimens were re-reviewed by a gynecologic pathologist. Standard statistical methods were used to describe oncologic outcomes per group.ResultsAmong 32 patients in the cohort, we found that 68.7% had a pathologic diagnosis of an incidental serous tubal intraepithelial carcinoma, while 31.3% had a pathologic diagnosis of microscopic high-grade serous carcinoma with associated serous tubal intraepithelial carcinoma. Notably, two patients (9%) with isolated serous tubal intraepithelial carcinoma developed primary peritoneal carcinoma within a median of 29 months after surgery. One-third of patients with microscopic cancer experienced recurrence despite receiving standard staging surgery and chemotherapy for early-stage disease. Most of the patients in the cohort were older at the time of risk-reducing surgery than recommended for their pathologic variant.ConclusionsThe study supports the critical need for timely risk-reducing surgery in high-risk populations, as well as a comprehensive pathologic examination along with vigilant post-operative surveillance. Consensus guidelines for management of serous tubal intraepithelial carcinoma are necessary to identify a group of patients at higher risk of progression to primary peritoneal carcinoma and optimize patient care.
Tmax >4 s volume predicts stroke recurrence in symptomatic intracranial atherosclerotic stenosis with optimal medical treatment
Authors: Yu Ying , Yu Junchao , Hou Zhikai , Chiu Tse-cheng , Liu Xiaobo , Pan Yuesong , Yan Long , Fu Weilun , Jia BaiXue , Lui WT , Wang Yongjun , Wang Rong , Miao Zhongrong , Lou Xin , Ma Ning 
Published: November 2024

BackgroundThe time to maximum (Tmax) profile based on computed tomography perfusion (CTP) provides a quantitative assessment of cerebral hemodynamic compromise. We aimed to delineate the Tmax profile in stroke patients with symptomatic intracranial atherosclerotic stenosis (ICAS) and to investigate its predictive role in stroke recurrence after optimal medical treatment.MethodsConsecutive patients with ischemic stroke within 30 days attributed to 50%–99% ICAS were prospectively enrolled. Baseline tissue volume at different perfusion parameter thresholds based on CTP was automatically calculated using the Rapid Processing of Perfusion and Diffusion (RAPID) software. All patients received optimal medical treatment. The primary outcome was a composite of stroke in the territory of qualifying artery or vascular death within 1 year.ResultsAmong 204 patients with symptomatic ICAS, the median volume of Tmax >4 s, Tmax >6 s, and relative cerebral blood flow (rCBF) <30% were 61 mL, 0 mL, and 0 mL, respectively. The 1 year rate of primary outcome was 16.2% (33/204). Tmax >4 s volume was significantly associated with the primary outcome (per 10 mL increase, adjusted hazard ratio (HR), 1.028 (1.008–1.049), P=0.005). The optimal cut-off value of Tmax >4 s volume for predicting the primary outcome was 83 mL. Patients with Tmax >4 s volume >83 mL had a higher risk of the 1 year primary outcome than those with Tmax >4 s volume ≤83 mL (adjusted HR, 7.346 (3.012–17.871), P<0.001), after adjusting for degree of stenosis and stroke mechanisms.ConclusionTmax >4 s volume is a promising perfusion parameter to define hemodynamic compromise in patients with symptomatic ICAS. Patients with a larger volume of Tmax >4 s are likely to have a higher risk of stroke recurrence despite optimal medical treatment.
Validation of a phase-field approach for contact line hysteresis against a sloshing droplet case
Authors: Bodziony Francisco , Govže Viktor , Dupuy Eva-Marie , Marschall Holger 
Published: November 2024

AbstractUnderstanding liquid propellants behavior in microgravity conditions is critical for efficient spacecraft design. For a number of operations, ranging from engine restart to orbital propellant storage and transfer, insight is needed to characterize capillary-dominated flows. In such conditions, surface tension and wetting properties, including contact angle hysteresis, can greatly impact the fluid’s behavior and therefore spacecraft performance. Using experimental data from ESA Propulsion Laboratory, a contact line model for the Cahn–Hilliard phase-field method is validated. The case studied is that of a droplet confined between two oscillating plates, which aims to isolate and observe contact angle-driven physics, limiting the effect of gravity on the flow in a simple and reproducible way on ground. The contact line model allows for the prediction of contact line motion without requiring the computation of dynamic contact angles or contact line velocities, thus simplifying implementation and reducing computational overhead. For the validation, contact line pinning and motion under varying oscillation frequencies is investigated. Specifically, the length between the rear and front contact line edges, as well as the shape of the sloshing droplet are compared. The results show good agreement between simulations and experimental data, confirming the model’s accuracy in predicting contact line behavior and pinning.
The Annealing Temperature Effect Enhances the Structural and Optical Parameters of Bi2Te3 Thermally Evaporated Thin Films
Authors: Salwa A. S. , Imam Amal M. , Satti Amira A. E. 
Published: November 2024

The current work investigates the influence of the annealing temperature (373, 473 K) on the structural and optical properties of Bi2Te3 thin films produced by the thermal evaporation technique. The crystal structure of samples is examined using an X-ray diffraction, indicating that Bi2Te3 thin films have a Rhombohedral structure with space group R-3m. The crystallite size (D) increased from 10.85 to 14.46 nm by increasing the annealing temperature. Additionally, increasing the annealing temperature reduces the micro-strain and the dislocation density from (3.33 × 10−3 to 2.5 × 10−3) and (8.49 × 1015 to 4.78 × 1015)

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m

2

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respectively. These micro-strain and dislocation density reductions refer to the crystallinity enhancement of sample Bi2Te3 thin films. The transmittance and reflectance spectra were measured using an Fourier transform infrared spectrometer. All samples reveal direct and indirect transition types and both direct and indirect optical energy gap decreased with increased annealing temperature from (0.325 to 0.29 eV) and (0.24 to 0.274 eV), respectively. From transmittance and reflectance data, the refractive index is calculated. These results reveal the refractive index decreasing as temperature annealing increased from (2.45–1.79) at 3250 nm. Other optical parameters such as absorption index, dielectric constant, energy loss function, and optical conductivity were estimated.
Data from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming 
Published: November 2024

<div>Abstract<p>HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all breast cancers. Recent studies have suggested that HER2-positive breast cancer is a group of heterogeneous diseases with different sensitivities to standard treatment regimens. Revealing the molecular heterogeneity of HER2-positive breast cancer could potentially enable more precise treatment strategies. In this study, we performed multiomics profiling on a HER2-positive breast cancer cohort and identified four transcriptome-based subtypes. The classical HER2 (HER2-CLA) subtype comprised 28.3% of the samples and displayed high ERBB2 activation and significant benefit from anti-HER2 therapy. The immunomodulatory (HER2-IM) subtype (20%) featured an immune-activated microenvironment, potentially suitable for de-escalated treatment and immunotherapy. The luminal-like (HER2-LUM) subtype (30.6%) possessed similar molecular features of hormone receptor–positive HER2-negative breast cancer, suggesting endocrine therapy and CDK4/6 inhibitors as a potential therapeutic strategy. Lastly, the basal/mesenchymal-like (HER2-BM) subtype (21.1%) had a poor response to current dual HER2-targeted therapy and could potentially benefit from tyrosine kinase inhibitors. The molecular characteristics and clinical features of the subtypes were further explored across multiple cohorts, and the feasibility of the proposed treatment strategies was validated in patient-derived organoid and patient-derived tumor fragment models. This study elucidates the molecular heterogeneity of HER2-positive breast cancer and paves the way for a more tailored treatment.</p><p><b>Significance:</b> Illumination of the inherent heterogeneity within HER2-positive breast cancers through the delineation of distinct molecular subtypes lays the groundwork for developing more personalized treatment strategies based on specific patient characteristics.</p></div>
PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression
Authors: Zhai Fengxian , Pan Guozheng , Xue Lei , Cheng Can , Wang Jiabei , Liu Yao , Liu Lianxin 
Published: November 2024

Abstract
Internal tandem duplication (ITD) in the FMS-like receptor tyrosine kinase-3 (FLT3) is one of the most frequent mutations in acute myeloid leukemia (AML) and is associated with poor prognosis. FLT3-ITD mutations result in endoplasmic reticulum (ER) retention and constitutive autophosphorylation of FLT3. The PR/SET domain 16 (PRDM16) is highly expressed in patients with FLT3-ITD+ AML, suggesting it might play a role in leukemogenesis. Here, we revealed that genetic and pharmacologic suppression of PRDM16 greatly slowed the progression of FLT3-ITD–driven leukemia, sensitized leukemic cells to tyrosine kinase inhibitors, and extended the survival of leukemic mice. PRDM16 enhanced activation of oncogenic FLT3-ITD and ligand-dependent activation of wild-type FLT3 in leukemic cells. Mechanistically, PRDM16 mediated monomethylation of FLT3-ITD at lysine-614 and promoted its ER localization, resulting in enhanced FLT3 signaling in leukemia cells. Moreover, pharmacologic suppression of FLT3-ITD methylation in combination with tyrosine kinase inhibitors increased the elimination of FLT3-ITD+ AML cells. Altogether, these results suggest that PRDM16 boosts oncogenic FLT3 signaling in leukemic cells by prompting FLT3-ITD methylation. Therefore, PRDM16 may serve as a therapeutic target for AML.
Significance: Monomethylation of FLT3-ITD at lysine-614 by PRDM16 induces FLT3 ER localization and enhanced signaling, which can be inhibited by targeting PRDM16 to suppress survival of FLT3-ITD+ AML cells and increase chemosensitivity.