bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load
Authors: Zupo Roberta , Castellana Fabio , Panza Francesco , Solfrizzi Vincenzo , Lozupone Madia , Tardugno Roberta , Cicero Nicola , Corbo Filomena , Crupi Pasquale , Sardone Rodolfo , Clodoveo Maria Lisa 
Published: November 2024

Background:
Mediterranean diet may enhance cognitive function and delay the progression
of Alzheimer's disease (AD). We conducted a systematic review to investigate the effect of
oleocanthal (OC) from extra-virgin olive oil (EVOO) on amyloid-β (Aβ) burden in preclinical models
of AD, considering the anti-inflammatory and neuroprotective effects of EVOO biophenols,
which are key components of the Mediterranean dietary model.

Methods:
The literature was searched through six electronic databases until February 2023. Screening
of 52 retrieved articles for inclusion criteria resulted in 7 preclinical reports evaluating the effect
of an OC-supplemented diet on AD trajectories by means of Aβ load or clearance in affected models.
Reports were appraised for risk of bias using the SYRCLE's RoB tool. A protocol was registered on
PROSPERO.

Results:
Case control prevailed over the case-crossover design, and the geographical distribution was
uniformly American. The study population mostly included 5xFAD, otherwise TgSwDI or wild-type
C57BL/6 mouse models. We found a role of OC in reducing Aβ load in the hippocampal parenchyma
and microvessels compared with controls. An increased cerebral clearance of Aβ through the bloodbrain
barrier and a substantial improvement in metabolic and behavioral parameters were also reported
in preclinical models under an OC-enriched diet. The risk of bias was shown to be moderate overall.

Conclusion:
Preclinical data are promising about the effects of OC from the Mediterranean diet's
EVOO in relieving the burden of Aβ in AD; however, further evidence is needed to corroborate the
efficacy of this biophenol and strengthen the speculated causal pathway.
Imidazole-Based Metal Complex Derivatives: A Comprehensive Overview of Synthesis and Biological Applications
Authors: Hiremath Arpita F. , M. R. Pradeep Kumar , Rajagopal Kalirajan , Barua Rashu , Obaidur Rab Safia , Alshehri Mohammed Ali , Bin Emran Talha 
Published: November 2024

Abstract:
The imidazole scaffold is a cornerstone in medicinal chemistry, widely recognized for its
extensive range of biological activities and ability to form stable metal complexes. This review
article provides a detailed overview of recent advancements in synthesizing, characterization, and
biological evaluation of metal-complexed imidazole derivatives. We explored various synthetic
strategies to create diverse metal-based imidazole complexes, emphasizing innovations that enhance
efficiency and yield. Furthermore, we delve into the biological profiling of imidazole derivatives,
summarizing key findings from studies investigating their antimicrobial, antifungal, anticancer,
and other therapeutic properties. Special attention is given to metal coordination's role in
modulating these compounds' biological activity. The review discusses the synthesis of imidazolemetal
complexes, illustrating how metal ions such as copper, zinc, and iron enhance the pharmacological
profiles of imidazole derivatives. Thus, the data from numerous studies was collated and
analyzed to comprehensively understand the current landscape and future prospects in imidazole
chemistry associated with metals. It is a valuable resource for researchers, guiding future investigations
and fostering the development of novel metal-based imidazole therapeutics.
Role of Dual GIP and GLP-1 Receptor Agonist, Tirzepatide in the Management of Weight Loss; A Systematic Review
Authors: Rangraze Imran Rashid , Khan Shehla , Wali Adil Farooq , Menezes Godfred , Goud Manjunatha , Jabran Muhammad 
Published: November 2024

Aim:
The eventuality of tirzepatide, a binary GIP and GLP- 1 receptor agonist, as a
treatment for rotundity and metabolic diseases is addressed in this comprehensive review.

Background:
A definition of tirzepatide is that it is an implicit intervention for rotundity, given
its effectualness per the cure-dependent effect. Beyond the beneficial effects on body weight loss,
tirzepatide also brings about an improvement in lipid biographies and insulin perceptivity, in harmony
with binary receptor activation.

Methodology:
Assaying data from seven phases 3 trials, it's constantly shown that tirizepatide reduces
body weight in a significant and clinically meaningful way for a variety of party biographies
and lengths of time.

Results:
The drug's effect was supported by its favorable safety profile, which shows low prevalence
rates of common adverse goods. Its efficacy in the management of type 2 diabetes is supported
by relative evaluations, underscoring the inevitability of its breakthrough as a therapeutic volition.
Treatment individualization is key, as evidenced by the tailor-made response proposed by
group analysis based on birth BMI. The efficacy, safety, and demand for personalized treatment
plans of tirzepatide are each supported in recommendations for clinical practice.

Conclusion:
Tirzepatide's eventuality as a long-term strategy for habitual rotundity is corroborated
by long-term follow-up studies that show sustained weight loss. Indeed with these encouraging
results, further study and clinical experience are demanded to completely comprehend the safety,
optimal integration, and long-term effectiveness of tirzepatide in a multiplicity of patient populations.
Non-alcoholic Wernicke Encephalopathy in a Young Patient with Adenocarcinoma of the Colon: A Case Report and Review of the Literature
Authors: Ziogou Afroditi , Lymperis Andreas , Skouteris Nikolaos , Charalampakis Nikolaos 
Published: November 2024

Introduction:
Wernicke Encephalopathy (W.E.) is an acute neurological disorder induced
by thiamine deficiency. Alcohol abuse is considered to be the leading cause of the disease;
however, numerous other conditions, such as malnutrition or cancer, have been identified as potential
risk factors.

Case Presentation:
Clinical manifestations include a typical triad of mental status alteration, nystagmus,
and ataxia and are attributed to damage in brain regions of high thiamine demand. The diagnosis
is mainly clinical and further supported by the immediate response of neurological signs
to parenteral thiamine administration. Among paraclinical examinations, brain MRI is considered
substantial for diagnosis and is supported by the determination of thiamine blood levels.

Conclusion:
Non-alcoholic W.E. is trickier to diagnose due to its atypical clinical course and risk
factors. We herein describe a case of non-alcoholic W.E. in a woman with colon cancer who gradually
developed the classic symptoms of thiamine deficiency.
Parkinson’s Disease: A Progressive Neurodegenerative Disorder and Structure-Activity Relationship of MAO Inhibitor Scaffolds as an Important Therapeutic Regimen
Authors: Salauddin  , Zaidi Syed Amir Azam , Ubaid Mohammed , Shamim Saniya , Naim Mohd. Javed , Khanna Suruchi , Alam Ozair 
Published: November 2024

Abstract:
Parkinson’s disease is considered an advancing neurodegenerative disorder with unknown
causes, and its association with some risk factors, including aging, family history, and exposure
to chemicals, makes it the second most common occurring neurodegenerative disorder
throughout the world with increasing prevalence. Parkinson’s disease is associated with slow
movement, rigidity, tremors, imbalance, depression, anxiety, cognitive impairment, orthostasis, hyperhidrosis,
sleep disorders, pain, and sensory disturbances. In recent decades, there has been a rise
in research on the development of effective and potential therapies for the treatment of Parkinson’s
disease. An important target for neuroprotection is Monoamine Oxidases (MAO), which hydrolyze
neurotransmitters like dopamine and produce very reactive free radicals as a by-product. Aging and
neurodegenerative illnesses cause overexpression in the brain, which exacerbates neuronal loss. The
treatment of Parkinson's disease with MAO inhibitors has shown promising outcomes. Herein, we
reported characteristic features of Parkinson’s disease, various treatment strategies, and the SAR of
potential drugs that can be explored further as lead for the development of newer molecules with
improved pharmacological profiles.
Advanced Technologies in Rectal Drug Delivery Systems: A Comprehensive Review of Recent Innovations and Future Prospects
Authors: Liew Kai Bin , Yahya Farah Shazwani , Azli Nur Dini Wardina , Segaran Abirami Sathia , Wong Yit Yien , Kee Phei Er 
Published: November 2024

Abstract:
Rectal Drug Delivery System (RDDS) emerges as an alternative administration route
due to the rectum's small surface area and limited enzyme activity, which contribute to efficient
drug absorption. RDDS offers various advantages, such as reduced first-pass metabolism, rapid absorption
of low molecular weight drugs, and the ability to accommodate large retention volumes
and facilitate absorption via the lymphatic system. Moreover, RDDS is preferable for drugs with
low stability, solubility, and permeability via oral administration, as well as effectively addressing
concerns related to gastric irritation or degradation. This review delves into the factors influencing
drug absorption in RDDS, including drug properties, formulation types, and physiological and
pathology-associated considerations. It further explores conventional RDDS, including enemas,
suppositories, tablets, gels, sprays, ointments, and creams, as well as novel approaches involving
nanoparticles, liposomes, microspheres, and solid lipid nanoparticles (SLNs) in rectal dosage
forms. Furthermore, the challenges and prospects of RDDS in treating rectal diseases are discussed.
This review provides valuable insights into the potential of RDDS, highlighting the importance
of continuous research and development in enhancing patient outcomes and advancing
healthcare practices.
Revealing the Unseen: Post COVID-19 Biomarkers, Severity, and Outcome Mysteries
Authors: Rosyid Alfian Nur , Puspitasari Arina Dery , Sensusiati Anggraini Dwi , Nugraha Jusak , Amin Muhammad 
Published: November 2024

Background:
Although the COVID-19 pandemic has passed, some patients still experience
post-COVID-19 symptoms. It has been reported that COVID-19 symptoms can persist for more
than three months after recovery.

Objective:
This study aims to analyze biomarkers, severity, and outcome factors associated with
post-COVID-19 symptoms.

Methods:
This prospective cohort study involves hospitalised COVID-19 patients who were followed
for up to 3 months after discharge. Clinical examinations and laboratory tests for MMP-9,
TIMP-1, and IL-6 were conducted during hospitalisation and after three months.

Results:
We enrolled 76 COVID-19 patients, with a mortality rate of 30.26%. Among them, 55 individuals
(30.91%) had no residual symptoms, 54.5% had acute COVID-19, 9.09% had ongoing
COVID-19, and 5.45% had long-term COVID-19. Symptomatic post-COVID-19 had oxygen demand
and respiratory rates higher than no-symptoms groups. Early IL-6, IL-10, MMP-9, and TIMP-
1 were lower in symptomatic post-COVID-19 compared to dead and asymptomatic post-COVID-19
groups. IL-6 and MMP-9 decrease, and TIMP-1 increases after cure. IL-6 significantly still increases
in post-COVID-19 symptoms compared to no-symptoms (p=0.01). Patients more than 50 years old
and critically ventilated patients are prone to have symptoms post-COVID-19.

Conclusions:
More than half of patients suffer from post-COVID-19 symptoms with various related
factors. Even though IL-6 decreases after recovery, IL-6 levels are still higher in symptomatic post-
COVID-19 patients.
PENGARUH KOMBINASI EKSTRAK KECIPIR (Psophocarpus tetragonolobus L.) DAN KACANG POLONG (Pisum sativum) TERHADAP JUMLAH FOLIKEL OVARIUM DAN STRUKTUR HISTOLOGI USUS HALUS TIKUS PUTIH (Rattus norvegicus)
Authors: Florean Yuan Dewi , Harjana Tri 
Published: November 2024

Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi ekstrak kecipir (Psophocarpus tetragonolobus L.) dan kacang polong (Pisum sativum) terhadap jumlah folikel ovarium dan struktur histologi usus halus tikus putih (Rattus norvegicus). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan satu perlakuan yaitu P0 sebagai kontrol, perlakuan P1 (25mg/ kgBB ekstrak biji kecipir + 75mg/ kgBB tikus ekstrak biji kacang polong), P2 (50mg/ kgBB ekstrak biji kecipir + 50mg/ kgBB biji kacang polong ), dan P3 (75mg/ kgBB ekstrak biji kecipir + 25mg/ kgBB ekstrak biji kacang polong). Data yang diamati adalah jumlah folikel ovarium serta kerusakan usus halus. Data masing-masing ovarium dianalisis menggunakan One Way Anova. Apabila terdapat pengaruh nyata, maka dilakukan uji lanjutan dengan uji Duncan’s Multiple Range Test (DMRT). Untuk organ usus halus dianalisis menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa pemberian kombinasi ekstrak kecipir dan kacang polong memberikan pengaruh nyata (P0,05) terhadap jumlah folikel ovarium tikus putih. Sedangkan struktur histologi usus halus tikus putih normal. Kata kunci: ekstrak kecipir dan kacang polong, jumlah folikel ovarium, struktur histologi usus halus, tikus putih.
POTENSI PEMANFAATAN ECO-ENZYM BERBASIS BUAH SEBAGAI PUPUK PADA PERTUMBUHAN SAWI HIJAU (Brassica juncea L.)
Authors: Nur Laila Nuri Amalia , - Suhartini 
Published: November 2024

Abstrak. Eco-enzym merupakan larutan atau cairan hasil fermentasi dari limbah organik. Penelitian ini bertujuan untuk mengetahui (1) potensi eco-enzym sebagai pupuk organik cair berdasarkan uji fisik, kimia dan uji kandungan unsur hara (2) pengaruh variasi konsentrasi eco-enzym berbasis buah terhadap pertumbuhan tanaman sawi hijau (Brassica juncea L.). Penelitian ini menggunakan 1 perlakuan. Data pada penelitian ini dianalisis menggunakan uji one way anova. Hasil penelitian menunjukkan bahwa: (1) Hasil yang didapatkan belum memenuhi standar mutu pupuk organik cair Keputusan Menteri No. 261/KPTS/SR.310/M/4/2019, karena ecoenzym mengandung C-organik (1,52%); pH (3,2); dan NPK (0,24%) (2) Variasi konsentrasi 2% merupakan konsentrasi terbaik untuk pertumbuhan tinggi tanaman dan jumlah daun tanaman sawi sehingga eco-enzym konsentrasi 2% berpotensi untuk dijadikan sebagai pupuk organik cair. Kata kunci : Eco-enzym, tanaman sawi, variasi konsentrasi
PENGARUH KOMBINASI KONSENTRASI ZAT PENGATUR TUMBUH NAA DAN 2-IP TERHADAP PERTUMBUHAN ANGGREK Dendrobium sp. SECARA IN VITRO
Authors: Suryani Suryani , Ratnawati Ratnawati 
Published: November 2024

Abstrak. Tujuan penelitian ini adalah untuk mengetahui pengaruh kombinasi konsentrasi NAA dan 2-iP dan interaksi kedua faktor terhadap pertumbuhan tunas aksiler anggrek Dendrobium sp., mengetahui kombinasi konsentrasi yang optimum dan posisi nodus terbaik, Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap Faktorial, terdiri dari dua faktor: kombinasi konsentrasi zpt (NAA (0; 0,05; 0,1; 0,15; 0,2), 2-iP (2; 1,5; 1; 0,5; 0) dan posisi nodus (atas, bawah, tengah) sebanyak 6 ulangan. Eksplan menggunakan anggrek silangan Dendrobium Apel Ireng (D.S.Santoso 2019) x Dendrobium Vian (D.S.Santoso 2018) dari Dede Orchid Malang dan memiliki 4 nodus. Medium dasar mengunakan New Phalaenopsis (NP)+Air Kelapa. Data yang diperoleh dianalisis menggunakan ANOVA. Jika terjadi beda nyata, analisis dilanjutkan dengan uji DMRT dengan taraf nyata 5%. Hasil penelitian menunjukkan bahwa penambahan 0,1 ppm NAA + 1 ppm 2-iP optimum pada pertumbuhan tunas aksiler anggrek Dendrobium Apel Ireng x Dendrobium Vian. Posisi nodus terbaik adalah posisi nodus bagian tengah. Tidak terdapat pengaruh penambahan variasi kombinasi konsentrasi zpt (NAA+2-iP) dalam menginduksi tunas aksiler pada semua parameter serta tidak terdapat interaksi variasi kombinasi konsentrasi zpt (NAA+2-iP) dan posisi nodus terhadap induksi tunas aksiler pada semua parameter. Kata kunci : NAA, 2-iP, Posisi Nodus, Dendrobium sp., Kultur Jaringan, Tunas Aksiler
Efficacy of a Wearable Activity Tracker With Step-by-Step Goal-Setting on Older Adults’ Physical Activity and Sarcopenia Indicators: Clustered Trial
Authors: Ho Mu-Hsing , Peng Chi-Yuan , Liao Yung , Yen Hsin-Yen 
Published: November 2024

Background
Smart wearable technology has potential benefits for promoting physical activity and preventing sarcopenia.

Objective
The purpose of this study was to explore the efficacy of a wearable activity tracker with 2-stage goal-setting for daily steps on older adults’ physical activity and sarcopenia indicators.

Methods
The study used a clustered trial design and was conducted in March to June 2022. Participants were community-dwelling adults older than 60 years who were recruited from 4 community centers in Taipei City. The intervention was designed with 2-stage goals set to 5000 steps/day in the first 4 weeks and 7500 steps/day in the final 4 weeks while wearing a commercial wearable activity tracker. Data were collected by self-reported questionnaires, a body composition analyzer, a handle grip tester, and 5 sit-to-stand tests.

Results
All 27 participants in the experimental group and 31 participants in the control group completed the 8-week intervention. Total and light-intensity physical activities, skeletal muscle index, and muscle strength increased, while sedentary time, BMI, and the waist circumference of participants decreased in the experimental group, with significant group-by-time interactions compared to the control group.

Conclusions
A wearable activity tracker with gradual goal-setting is an efficient approach to improve older adults’ physical activity and sarcopenia indicators. Smart wearable products with behavioral change techniques are recommended to prevent sarcopenia in older adult populations.
A Contrastive Study of Chinese-English Translation of Ancient Poetry from the Perspective of Aesthetics of Reception: A Case Study of the Two Translations of Vain Longing
Authors: Wang Mengyao 
Published: November 2024

The Chinese literary classic "Dream of the Red Chamber" features a variety of poems and songs, with "Vain Longing," which serves as its theme song, being particularly popular among readers both domestically and internationally. Among the many translations available, those by Yang Xianyi and Gladys Yang, along with Hawkes' version, are the most prominent and hold significant research value. Acceptance Aesthetics, which emerged from the German critical school in the 20th century, provides a fresh lens through which to view the translation of ancient Chinese poetry. This paper utilizes Aesthetics of reception as its theoretical framework and focuses on the English translations of "Vain Longing" by Yang Xianyi and Gladys Yang as well as Hawkes found in "Dream of the Red Chamber." By examining their translation philosophies and approaches, this study aims to contribute insights for translating ancient poetry within literary contexts while enhancing global appreciation for Chinese poetic beauty and promoting classical Chinese culture.
RANCANG BANGUN ALAT PRAKTIKUM EFEK HALL DAN PENENTUAN MUATAN ELEKTRON PADA MATA KULIAH FISIKA MODERN MENGGUNAKAN MIKROKONTROLER ATMEGA 328
Authors: Kalsum Ummu , N Andi Rosman 
Published: November 2024

Abstrak: Telah dilakukan penelitian rancang bangun alat praktikum efek Hall dan penentuan muatan elektron menggunakan mikrokontroler Atmega 328. Penelitian ini bertujuan untuk merancang dan membangun alat praktikum efek Hall serta penentuan muatan elektron menggunakan mikrokontroler Atmega 328. Metode yang digunakan adalah penelitian dan pengembangan (Research and Development) dengan model Borg & Gall, yang terdiri dari tujuh tahap. Hasil validasi alat menunjukkan bahwa alat yang dirancang mendapatkan nilai rata-rata 3,1 dari validator, yang menunjukkan kelayakan alat tersebut. Percobaan menggunakan alat ini melibatkan pengukuran arus dan medan magnet pada efek Hall serta arus pada LED dalam penentuan muatan elektron. Berdasarkan uji coba dan respon praktikan, alat ini dinilai mudah digunakan dan efektif dalam mendukung pemahaman konsep fisika modern, dengan rata-rata penilaian sebesar 3,42. Kesimpulannya, alat ini layak digunakan dalam praktikum fisika modern. Kata Kunci: Fisika modern, alat praktikum, efek hall, muatan elektron, mikrokontroler Atmega 328. Abstract: Research has been conducted on the design of the Hall effect practicum tool and the determination of electron charge using the Atmega 328 microcontroller. This study aims to design and build a Hall effect practicum tool and electron charge determination using an Atmega 328 microcontroller. The method used is research and development (Research and Development) with the Borg & Gall model, which consists of seven stages. The results of the tool validation show that the designed tool gets an average score of 3.1 from the validator, which indicates the feasibility of the tool. Experiments using this tool involve measuring the current and magnetic field in the Hall effect as well as the current in the LED in determining the electron charge. Based on trials and practitioner responses, the tool is considered easy to use and effective in supporting the understanding of modern physics concepts, with an average rating of 3.42. In conclusion, this tool is suitable for use in modern physics practicum. Keywords: Modern physics, lab kit, hall effect, electron charge, Atmega 328 microcontroller
An empirical study on students’ personalized teaching mode and educational effect of combining artificial intelligence technology in college civics education
Authors: Wu Jianan 
Published: November 2024

Abstract
With the rapid popularization of the new generation of information technology, education informatization has become a major trend in today’s education development, and more and more intelligent educational assistance platforms have emerged. The study proposes an empirical Q-matrix neurocognitive diagnostic model by introducing a neurocognitive diagnostic model, which improves the diagnostic effect of the NCD-Q model by learning the complex interaction function between students and exercises through neural networks. CFR-CD, an enhanced personalized exercise recommendation technique, is proposed to create a learner model of similar exercise expertise using a collaborative filtering algorithm. The CFR-CD algorithm is tested experimentally against other recommendation algorithms by suggesting exercises that are based on students’ knowledge mastery and similar learners’ answer data. Among them, the recommended effect of the CFR-CD model on simple test questions is better than the NMF model, the precision rate of the CFR-CD model is improved by about 3% on 50% and 60% of test question test sets, and the recall rate and F1 value of this model are the best among the three models. Finally, the experimental pre and post-tests were conducted to explore the teaching effect of the CFR-CD model in Civics education, and three dimensions, as well as sub-dimensions, were divided to analyze the influence effect of the CFR-CD model, which concluded that the Civics character, cultural literacy, and value concepts were all improved, among which the improvement effect of Civics character was the most obvious.