bluuebunny/crossref_metadata_2025_split huggingface dataset:
ON THE PROBLEMS OF IDENTIFICATION OF INFORMATION SOURCES BEING DISCOVERED IN THE COURSE OF CITATION STUDIES WITH THE USE OF JOURNAL CITATION REPORTS®
Authors: Lazarev V. S. , Yurik I. V. 
Published: July 2018

During the citation study of serial publications with the use of Journal Citation Reports®(JCR) a number of items are being revealed (among others) which abbreviated titles cannot be identified with the use of the JCR itself. Typically, such sources are considered unimportant, because they do not have an «impact factor». However, our analysis of the information sources, which abbreviated titles could not be identified with the use of the Journal Citation Reports® itself, convinced us that such sources can be really useful for the specialists. It was also discovered that in the JCR there are mistakes of writing of abbreviated titles in two different ways that relate even the periodicals included in the «master list», i. e. the sources having abbreviated titles established for JCR. The content of the present citation study of serial publications in relation to their ability to support research in the subject of «energy security and energy efficiency, energy efficient technologies and appliances» has made it possible to identify a number of different consequences of such mistakes and the reasons for them. It was found, for example, that the use of double and multiple different abbreviations for the titles of the same serial publication is either due to their objectively existing dual title misinterpreted by the indexers, or due to the inclusion in the citation data of the JCR full titles of the serial publications along with the abbreviated ones, and also by the inclusion in such data in some cases the year of publication or by indicating that the publication issue represents the conference proceedings. All the hard-to-identify abbreviations compel a bibliometrician to take time-consuming laborious identifications and verifications of such titles often followed by the recount of the resulting data.
Spatiotemporal Variability in Microbial Quality of Western US Agricultural Water Supplies: A Multistate Study
Authors: Partyka Melissa L. , Bond Ronald F. , Chase Jennifer A. , Atwill Edward R. 
Published: July 2018

In 2011, the US Congress passed the Food Safety Modernization Act, which tasks the US Food and Drug Administration to establish microbiological standards for agricultural water. However, little data are available for the microbiological quality of surface water irrigation supplies. During the 2015 irrigation season, we conducted a baseline study on the microbial water quality of large irrigation districts in California (n = 2) and Washington (n = 4). Monthly samples (n = 517) were analyzed for bacterial indicators (fecal coliforms, enterococci, and Escherichia coli) and pathogens (Salmonella spp., E. coli O157, and non‐O157 Shiga toxin‐producing E. coli [STEC]). Although there was a high degree of variability (μ ± SD = 59.13 ± 106.0), only 11% of samples (56/517) exceeded 126 colony‐forming units (CFU) 100 mL−1, and only six samples exceeded 410 CFU 100 mL−1. Two volumes of water were collected for pathogen analysis (1 L and 10 L); prevalence of Salmonella in 10‐L samples (68/149) was nearly double of that found in 1‐L samples (132/517). We found STEC during ∼9% of sampling events (58/517); serotypes O26 and O45 were the most common at 31 and 26%, respectively. Pathogens were not associated with exceedance of the regulatory threshold, yet the odds of detecting Salmonella increased approximately threefold (odds ration [O.R.] = 3.14, p < 0.0001) for every log increase in turbidity. Microbiological outcomes were highly district‐specific, suggesting drivers of water quality vary across spatiotemporal scales. The true risk of contamination of produce from irrigation water supplies remains unknown, along with the optimal monitoring strategy to improve food safety.Core Ideas
Western US irrigation water supplies rarely exceed FDA agricultural water standards.
Indicator bacteria are not predictive of pathogen prevalence or concentration.
Prevalence of pathogens in irrigation water is higher than previously reported.
Odds of detecting Salmonella improved >270% with an increase in sample volume.
More research is needed to provide science‐based guidance to the produce industry.
Transferability of Vis‐NIR models for Soil Organic Carbon Estimation between Two Study Areas by using Spiking
Authors: Hong Yongsheng , Chen Yiyun , Zhang Yong , Liu Yanfang , Liu Yaolin , Yu Lei , Liu Yi , Cheng Hang 
Published: July 2018

Core Ideas
Vis‐NIR spectroscopy was applied to estimate soil organic carbon in two different study areas.
Model developed in one study area couldn't be transferred in the other area.
We used spiking strategy to adapt the calibration models to target area characteristics.
|s2–σ2| could be used to identify the optimal spiking samples to improve model transferability.
Visible and near infrared (Vis‐NIR) spectroscopy technique has been shown to be a cost‐effective alternative for rapidly analyzing soil organic carbon (SOC). However, great challenges remain when applying a Vis‐NIR model for SOC estimation developed in one study area to other study areas without further calibration. The scope of this study was to use spiking strategy to improve the transferability of Vis‐NIR models between two study areas. Specifically, we explored the optimal spiking subset by adding different quantities of spiking samples to construct different‐sized models, and the strategy of spiking with extra‐weighting was used for comparison. Soil data was acquired in two independent study areas (WH area and HH area) in Hubei Province, Central China. The reflectance spectra and SOC contents were measured in the laboratory. Partial least squares regression (PLSR) was used for model calibration. The representativeness of the spiking samples was assessed through the absolute difference between the selected sample variance (s2) and the original variance (σ2) in the principal component space derived from soil spectra. Results showed that the initial models yielded successful SOC predictions for the soil samples from the same area as the calibration samples, but failed in those samples from the other area. Spiking improved the model transferability between these two study areas. Approximately 33%/48% of the HH/WH calibration set was required as spiking samples in model calibrations and applications in the other area. Spiking with extra‐weighting was of limited use in small‐sized spectral libraries. The use of |s2–σ2| is potentially effective in identifying the optimal spiking samples to improve model transferability between different small‐sized study areas in the Vis‐NIR assessments of SOC.
Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications
Authors: Saftić Dijana , Ban Željka , Matić Josipa , Tumirv Lidija-Marija , Piantanida Ivo 
Published: July 2018

:
Among the most intensively studied classes of small molecules (molecular weight
< 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA,
and another intensively studied class is nucleobase derivatives. Both classes have been intensively
elaborated in many books and reviews. However, conjugates consisting of DNA/RNA
binder covalently linked to nucleobase are much less studied and have not been reviewed in
the last two decades. Therefore, this review summarized reports on the design of classical
DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various
DNA or RNA targets, and even in some cases protein targets are involved. According to
these data, the most important structural aspects of selective or even specific recognition between
small molecule and target are proposed, and where possible related biochemical and
biomedical aspects were discussed. The general conclusion is that this, rather new class of
molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in
the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead
research lines show promising advancements toward either novel, highly selective markers or
bioactive, potentially druggable molecules.
Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
Authors: Santos Mercedes , Serrano-Dúcar Sofía , González-Valdivieso Juan , Vallejo Reinaldo , Girotti Alessandra , Cuadrado Purificación , Arias Francisco Javier 
Published: July 2018

:
Protein-based polymers are some of the most promising candidates for a new generation
of innovative biomaterials as recent advances in genetic-engineering and biotechnological
techniques mean that protein-based biomaterials can be designed and constructed with
a higher degree of complexity and accuracy. Moreover, their sequences, which are derived
from structural protein-based modules, can easily be modified to include bioactive motifs that
improve their functions and material-host interactions, thereby satisfying fundamental biological
requirements.

:
The accuracy with which these advanced polypeptides can be produced, and their versatility,
self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have
attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering,
protein purification, surface engineering and controlled drug delivery.

:
The biopolymers discussed in this review are elastin-derived protein-based polymers which
are biologically inspired and biomimetic materials. This review will also focus on the design,
synthesis and characterization of these genetically encoded polymers and their potential utility
for controlled drug and gene delivery, as well as in tissue engineering and regenerative medicine.
Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development
Authors: Swingle Mark R. , Honkanen Richard E. 
Published: July 2018

Background:The reversible phosphorylation of proteins regulates many key functions in eukaryotic cells. Phosphorylation is catalyzed by protein kinases, with the majority of phosphorylation occurring on side chains of serine and threonine residues. The phosphomonoesters generated by protein kinases are hydrolyzed by protein phosphatases. In the absence of a phosphatase, the half-time for the hydrolysis of alkyl phosphate dianions at 25º C is over 1 trillion years; knon ~2 x 10-20 sec-1. Therefore, ser/thr phosphatases are critical for processes controlled by reversible phosphorylation.Methods:This review is based on the literature searched in available databases. We compare the catalytic mechanism of PPP-family phosphatases (PPPases) and the interactions of inhibitors that target these enzymes.Results:PPPases are metal-dependent hydrolases that enhance the rate of hydrolysis ([kcat/kM]/knon ) by a factor of ~1021, placing them among the most powerful known catalysts on earth. Biochemical and structural studies indicate that the remarkable catalytic proficiencies of PPPases are achieved by 10 conserved amino acids, DXH(X)~26DXXDR(X)~20- 26NH(X)~50H(X)~25-45R(X)~30-40H. Six act as metal-coordinating residues. Four position and orient the substrate phosphate. Together, two metal ions and the 10 catalytic residues position the phosphoryl group and an activated bridging water/hydroxide nucleophile for an inline attack upon the substrate phosphorous atom. The PPPases are conserved among species, and many structurally diverse natural toxins co-evolved to target these enzymes.Conclusion:Although the catalytic site is conserved, opportunities for the development of selective inhibitors of this important group of metalloenzymes exist.
In Silico Analyses for Key Genes and Molecular Genetic Mechanism in Epilepsy and Alzheimer’s Disease
Authors: Jiang Xiao-wen , Lu Hong-yuan , Xu Ziru , Liu Tian-yi , Wu Qiong , Yang Yue , Zhao Qing-chun , Gao Hui-yuan 
Published: July 2018

Background:
Epilepsy and Alzheimer's disease are common neuropathies with a complex
pathogenesis. Both of them have some correlations in etiology, pathogenesis, pathological changes,
clinical manifestations and treatment.

Objective:
This study investigated the key genes and molecular genetic mechanism in epilepsy and
Alzheimer’s disease by bioinformatics analysis.

Method:
Two gene expression profiles were used to screen differentially expressed genes by GEO2R
tool. The Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment
analysis was performed using the Database for Annotation, Visualization and Integrated Discovery
(DAVID). Then the protein-protein interaction (PPI) network was constructed by Search Tool
for the Retrieval of Interacting Genes (STRING) and Cytoscape software which can be used to analyze
modules with MCODE.

Results:
A total of 199 differentially expressed genes (DEGs) in the two groups. According to GO_BP
analysis and KEGG pathway enrichment by DAVID, we found DEGs referring to several pathways
significantly down-regulated in endocytosis, such as endocytosis, synaptic vesicle cycle, lysosome,
cAMP signaling pathway, circadian entrainment, LTP, glutamatergic synapse and GABAergic synapse
pathway. The regulator genes of the upstream pathway of circadian rhythms were obviously downgraded.

Conclusion:
Our research demonstrated that the regulatory genes of the upstream pathway of circadian
rhythms were obviously downgraded. These biological pathways and DEGs or hub genes may contribute
to revealing the molecular relationship between Alzheimer's disease and epilepsy.
Sustainability metrics for assessing water resource recovery facilities of the future
Authors: Cornejo Pablo K. , Becker Jennifer , Pagilla Krishna , Mo Weiwei , Zhang Qiong , Mihelcic James R. , Chandran Kartik , Sturm Belinda , Yeh Daniel , Rosso Diego 
Published: July 2018

AbstractThe recovery of water, energy, and nutrients from water resource recovery facilities (WRRFs) is needed to address significant global challenges, such as increasing water demand and decreasing availability of nonrenewable resources. To meet these challenges, innovative technological developments must lead to increased adoption of water and resource recovery processes, while addressing stakeholder needs (e.g., innovators, practitioners, regulators). A test bed network of over 90 partner facilities within the United States and abroad will help accelerate innovation and widespread adoption of novel processes through multiscale testing and demonstration of technologies. In this paper, we define a common set of environmental, economic, technical, and social performance metrics for innovative technologies, that will meet the needs of multiple stakeholders in the decision‐making process. These triple bottom line performance metrics can be used to track the sustainability of technologies in a consistent and transparent manner, while aiding the decision‐making process for WRRFs.Practitioner points

The Facilities Accelerating Science and Technology (FAST) Water Network includes over 90 test bed facilities dedicated to accelerating innovation and adoption of water energy, and nutrient recovery systems.

A common set of environmental, economic, technical, and social performance metrics should be measured and reported when a new technology is evaluated in the FAST Water Network.

Performance metrics can aid sustainable decision‐making at WRRF, while meeting the needs of multiple stakeholders.
Development of a Model to Determine the Baseline Mass Transfer Coefficient in Bioreactors (Aeration Tanks)
Authors: Lee Johnny 
Published: July 2018

AbstractOver 60 percent of all wastewater treatment plants in the developed countries use the activated sludge process as their secondary treatment system. About 50 to 85 percent of the total energy consumed in a biological wastewater treatment plant is in aeration. The activated sludge process, the most common such process, is performed in large aeration basins to provide air for microorganisms to remove nutrients and pollutants through biodegradation. Designs for the air supply often fail to meet sustained peak organic loading, which may lead to unsatisfactory treatment performance and even plant failure. On the other hand, excessive safety factors used in design for the air supply may similarly lead to unsatisfactory treatment performance and energy wastage. Improper sizing of the aeration system is primarily due to inability to estimate the mass transfer coefficient (KLa) correctly for different tank depths, leading to improper blower design and to inappropriate operation, among other things. In general, the efficiency of porous fine‐bubble diffuser systems varies from 10 to 30 percent or more, depending on tank depth. The term KLa is used in ASCE/EWRI Standard 2‐06 to define the apparent volumetric mass transfer coefficient in a non‐steady‐state clean water test in an aeration tank. This parameter is a function of tank depth, due to the variation of oxygen gas depletion with depth. The objective of this paper is to introduce a baseline oxygen mass transfer coefficient (KLa0), a hypothetical parameter defined as the oxygen transfer rate coefficient at zero depth, and to develop new models relating KLa to the baseline KLa0 as a function of temperature, system characteristics (e.g., the gas flow rate, the diffuser depth Zd), and oxygen solubility (Cs). Results of this study on data extracted from the literature indicate that a uniform value of KLa0 that is independent of tank depth can be obtained experimentally. Using the baseline, a family of rating curves for KLa20 (the standardized KLa at 20 °C) can thus be constructed for various gas flow rates applied to various tank depths. The new model relating KLa to the baseline KLa0 is an exponential function, and (KLa0)T is found to be inversely proportional to oxygen solubility in water (Cs)T to a high degree of correlation. Using a predetermined baseline KLa0, the new model predicts oxygen transfer coefficients KLa20 for any tank depth to within 1–3% error compared to observed measurements, and similarly for the standard oxygen transfer efficiency. The discovery of a standard baseline (KLa0)20 determined from shop tests is important for predicting the KLa20 value for any other aeration tank depth and gas flowrate, and this finding can be used in the development of energy optimization strategies for wastewater treatment plants. This work may also improve the accuracy of aeration models used for aeration system evaluations.
A Locally Developed Electronic Health Platform in Uganda: Development and Implementation of Stre@mline
Authors: Liang Li , Wiens Matthew O , Lubega Phaisal , Spillman Ian , Mugisha Samuel 
Published: July 2018

Background
Electronic health records (EHRs) are especially important in low-resource settings due to their potential to address unique challenges such as a high number of patients requiring long-term treatments who are lost to follow-up, the frequent shortages of essential drugs, poor maintenance and storage of records, and inefficient clinical triaging. However, there is a lack of affordable and practical EHR solutions. Stre@mline is an EHR platform that has been locally developed by Ugandan clinicians and engineers in Southwestern Uganda. It is tailored to the specific context and needs of low-resource hospitals. It operates without internet access, incorporates locally relevant standards and key patient safety features, has a medication inventory management component, has local technical support available, and is economically sustainable without funding from international donors. Stre@mline is currently used by over 60,000 patients at 2 hospitals, with plans to expand across Uganda.

Objective
The purpose of this article is to describe the key opportunities and challenges in EHR development in sub-Saharan Africa and to summarize the development and implementation of a “Made-for-Africa” EHR, Stre@mline, and how it has led to improved care for over 60,000 vulnerable patients in a rural region of Southwestern Uganda.

Methods
A quantitative user survey consisting of a set of 33 questions on usability and performance was conducted at Kisiizi Hospital. Users responded to each question through a Likert scale with the values of strongly disagree, disagree, agree, and strongly agree. Through purposive sampling, 30 users were identified and 28 users completed the survey.

Results
We found that users were generally very satisfied with the ease of use of Stre@mline, with 96% (27/28) finding it easy to learn and 100% (28/28) finding it easy to use. Users found that Stre@mline was helpful in improving both clinical efficiency and enhancing patient care.

Conclusions
The partnership of local clinicians and developers is crucial to the design and adoption of user-centered technologies tailored to the specific needs of low-resource settings. The EHR described here could serve as a model for the development of future technologies suitable for developing countries.
The Development Strategy of Soybean Agribusiness in PT Lentera Panen Mandiri
Authors: Nurpitasari Dewi , Waluyati Lestari Rahayu , Mulyo Jangkung Handoyo 
Published: July 2018

The aims of this study are to identify both internal and external factors of agribusiness in PT Lentera Panen Mandiri (PT LPM), map the company’s position, and determine its development strategy. Main data used in this study is primary data obtained from stakeholders of PT LPM by direct interview. Strength, Weakness, Opportunity and Threat (SWOT) of soybean agribusiness in PT LPM were identified in this study and followed by determining the company’s position using SWOT diagram. Alternative srategies were derived from the SWOT matrix and prioritized using Quantitative Strategies Planning Matrix (QSPM) analysis. The results of this study identified 5 strengths, 7 weaknesses, 9 opportunities, and 6 threaths with the highest factors consisted as "company's commitment to supervise and foster farmers and suppliers", "is time-consuming sorting process and potency of mixed between rice and soybean", "opportunity to increase the productivity of soybean at farmer level ", and "uncommit suppliers to supply only from areas that have been approved by the company" respectively. Based on the SWOT diagram, soybean agribussiness in PT LPM positioned in Quadrant I, which mean that the company should apply Agressive Strategy or Strength – Opportunity (S-O) strategy. Based on the SWOT Matrix, 5 alternative of S-O strategies were derived. Based on the QSPM analysis, strategy for guarding and coaching farmers through patnership scheme is the first priority with Total Attarctive Score (TAS) is 12.9.
Britannia: violência, poder e contato
Authors: Bélo Tais Pagoto 
Published: July 2018

Este artigo tem por intuito demonstrar – por meio de fontes escritas de autores antigos, como as obras de Tácito (Anais e A vida de agrícola) e a de Dião Cássio (História de Roma) – como é descrita a violência da ocupação da província da Britannia, uma vez que a imposição do poder romano trouxe consequências para a vida da comunidade nativa dessa região. As rebeliões em destaque são a de Carataco e, principalmente, a de Boudica, dando maior ênfase na questão da violação das filhas da rainha dos iceni. Tal passagem corrobora os comentários acerca do ponto de vista de estudiosos da atualidade em relação a esse tema e a questão sobre o motivo pelo qual esses escritores da Antiguidade o apresentaram com tal veemência. As implicações do processo de invasão romana e a tomada da província vieram de resultados posteriores, que são demonstrados neste trabalho através da cultura material representada por epitáfios, pelos quais são conhecidas as vidas das mulheres nativas que se juntaram aos romanos, formando uma heterogeneidade cultural.