bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysphagia: Interprofessional Management, Impact, and Patient‐Centered Care
Authors: McGinnis Carol Marie , Homan Kimberly , Solomon Meghan , Taylor Julia , Staebell Kimberly , Erger Denise , Raut Namrata 
Published: December 2018

AbstractDysphagia affects a multitude of people worldwide with tremendous impact on the affected individual, families, and caregivers. Understanding dysphagia, as well as the status of screening, evaluation, and treatment, aids in the knowledge required by a interprofessional team to holistically care for patients with dysphagia and their caregivers. The impact of dysphagia includes potential associated risk and a cascade of effects. Conversations regarding meeting nutrition and fluid needs with consideration for quality of life need to be integrated into the plan of care for individuals with dysphagia.
Urinary Metabolic Signature of Primary Aldosteronism: Gender and Subtype‐Specific Alterations
Authors: Lana Alessandro , Alexander Keisha , Castagna Annalisa , D'Alessandro Angelo , Morandini Francesca , Pizzolo Francesca , Zorzi Francesco , Mulatero Paolo , Zolla Lello , Olivieri Oliviero 
Published: December 2018

PurposeThe current clinical investigation for primary aldosteronism (PA) diagnosis requires complex expensive tests from the initial suspicion to the final subtype classification, including invasive approaches; therefore, appropriate markers for subtype definition are greatly desirable. The present study performs a metabolomics analysis to further examine specific molecular signatures of PA urinesExperimental designThe study considered PA subtype and gender‐related differences using two orthogonal advanced UHPLC‐MS metabolomics approaches. Patients with essential hypertension (n = 36) and PA (n = 50) who were referred to the outpatient hypertension clinic and matched healthy subjects (n = 10) are investigated.ResultsStatistically significant changes (p < 0.05 ANOVA, Fc > 1.5) of metabolites involved in central carbon, energy, and nitrogen metabolism are identified, especially purine and pyrimidine nucleosides and precursors, and free amino acids. PLS‐DA interpretation provides strong evidence of a disease‐specific metabolic pattern with dAMP, diiodothyronine, and 5‐methoxytryptophan as leading factors, and a sex‐specific metabolic pattern associated with orotidine 5‐phosphate, N‐acetylalanine, hydroxyproline, and cysteine. The results are verified using an independent sample set, which confirms the identification of specific signatures.Conclusions and clinical relevanceMetabolomics is used to identify low molecular weight molecular markers of PA, which paves the way for follow‐up validation studies in larger cohorts.
Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification
Authors: Balluff Benjamin , Buck Achim , Martin‐Lorenzo Marta , Dewez Frédéric , Langer Rupert , McDonnell Liam A. , Walch Axel , Heeren Ron M.A. 
Published: December 2018

ScopeIn biomedical research, mass spectrometry imaging (MSI) can obtain spatially‐resolved molecular information from tissue sections. Especially matrix‐assisted laser desorption/ionization (MALDI) MSI offers, depending on the type of matrix, the detection of a broad variety of molecules ranging from metabolites to proteins, thereby facilitating the collection of multilevel molecular data.Lately, integrative clustering techniques have been developed that make use of the complementary information of multilevel molecular data in order to better stratify patient cohorts, but which have not yet been applied in the field of MSI.Materials and MethodsIn this study, the potential of integrative clustering is investigated for multilevel molecular MSI data to subdivide cancer patients into different prognostic groups. Metabolomic and peptidomic data are obtained by MALDI‐MSI from a tissue microarray containing material of 46 esophageal cancer patients. The integrative clustering methods Similarity Network Fusion, iCluster, and moCluster are applied and compared to non‐integrated clustering.ConclusionThe results show that the combination of multilevel molecular data increases the capability of integrative algorithms to detect patient subgroups with different clinical outcome, compared to the single level or concatenated data. This underlines the potential of multilevel molecular data from the same subject using MSI for subsequent integrative clustering.
Using the Distinct Population Segment (DPS) Concept to Protect Fishes with Low Levels of Genomic Differentiation: Conservation of an Endemic Minnow (Hitch)
Authors: Baumsteiger Jason , Young Matthew , Moyle Peter B. 
Published: December 2018

AbstractIn the United States, the Endangered Species Act (ESA) of 1973 was enacted to conserve species that are endangered or threatened throughout all or a portion of their range. The definition of “species” includes subspecies and distinct population segments (DPSs). Among freshwater fishes, the use of DPS designations has largely been restricted to salmonids, although the DPS concept is increasingly applied to other fishes as well. As more taxa approach threatened status, the difficult question becomes what to do when genetic evidence does not strongly support formal taxonomic designations (full species or subspecies). We examine the potential application of the DPS concept to protect fishes by using the example of the Hitch Lavinia exilicauda, a cyprinid fish that is endemic to California. The Hitch is divided into three formally described, geographically separate subspecies (the Sacramento, Monterey, and Clear Lake Hitches). However, genomic studies (i.e., restriction site‐associated DNA sequencing), presented here with three independent analyses using a large data set, only weakly supported subspecies designations. Results suggested population structure but not subspecies structure. Nevertheless, conventional taxonomic methods, strong contemporary isolation, the importance of protecting genetic diversity, and high cultural value still qualify all three designated subspecies for DPS status and demonstrate how taxa such as the Clear Lake Hitch can warrant protection under the ESA.
Integrating creativity into an English as a foreign language reading classroom
Authors: Chen Cheryl Wei‐yu 
Published: December 2018

AbstractThis article describes how creativity is integrated into an English as a foreign language (EFL) reading classroom for a class of adolescent readers in Taiwan. The chosen focal material was a book called Our Iceberg Is Melting by John Kotter and Holger Rathgeber, and the four language learning units in which creativity was infused were (1) dramatic reading; (2) watching relevant videos; (3) poster sessions; and (4) writing possible plots for the sequel. Student works were included to showcase students’ creativity and how the units were closely connected to language learning. It is hoped that more language teachers will integrate creative elements into their teaching to transform their teaching and classrooms.
Six blocks down, take a left at the corner: Learning to teach English learners outside the school walls
Authors: Khasnabis Debi , Reischl Catherine H. 
Published: December 2018

AbstractIn this article we report on a three‐staged teacher education model, designed to support the development of culturally responsive teaching practice in teacher candidates who are preparing to work with multilingual learners. The creative focus of this model is most pronounced in our effort to enable teacher candidates to “get out of context” of the school setting and to envision curricular possibilities by looking to the community. Our teacher education model assists teacher candidates (TCs) to learn community‐based culturally responsive teaching pedagogies for multilingual learners through (1) supporting culturally responsive teaching practice in the abstract, (2) engaging practice that pushes past the confines of the school walls, and (3) putting it all together in a community‐focused unit of instruction. We advocate for the creative potential of positioning TCs’ learning outside of the school walls and inside the community. For each stage of our model, we provide examples of practice using data from a unit of instruction titledMaking a Living—Making a Lifethat teacher candidates co‐created with the authors and experienced teachers. The unit was designed for a summer program in a U.S. Midwestern community for approximately one hundred fourth‐ to eighth‐grade English learners.
Improvisation: A creative theatrical technique to engage English language learners
Authors: Piccoli Margaret W. 
Published: December 2018

AbstractThis article addresses how theatrical improvisation can be used as a creative teaching tool to develop English language learners’ listening and speaking skills, to create an environment that encourages them to use the target language, and to gain confidence in their own abilities and experiences to become successful English speakers. Improvisation can achieve these goals by mimicking the creativity of daily language interactions. Finally, an improvisational lesson example is provided detailing a few activities and the structure on how to implement the technique.
Creative writing as a second language: What is creativity for second language writers?
Authors: Eda Hancı‐Azizoğlu B. 
Published: December 2018

The purpose of this autoethnographic study is to advance our understanding regarding the use of the creative function of a second language respecting the second language writer's insight, mindset, and perceptions. This conceptual autoethnographic study explored how creative writing in a first language differs from using the creative function in a second language. The study revealed that after using the poetic function of language, the author experienced progress in her writing because of the following enlightening arguments:The author felt encouraged to use her second language in more advanced and sophisticated styles as a result of trying to use the creative function of her second language in figurative ways that she has never tried before.Searching for solutions to write in her second language creatively allowed the multilingual author to discover new literary lexical and semantic connotations, and this process improved her style by enriching her vocabulary choice.The author gained metacognitive awareness in order to express herself in more meaningful ways because using the creative function of her second language pushed her boundaries to use words out of their daily ordinary meanings.
Evaluation of Wind‐Energy Survey Protocols for Migrating Eagle Detection
Authors: Chabot Eric , Slater Steve 
Published: December 2018

ABSTRACTWind energy development is increasing in the United States and Canada and may affect bald (Haliaeetus leucocephalus) and golden eagle (Aquila chrysaetos) populations through direct mortality. Wind farms on ridge‐tops may present a greater mortality threat because of the importance of these features for migrating raptors. Regulators in both countries recommend methods for preconstruction surveys, so that eagle use and collision risk can be assessed at potential construction sites. We obtained hourly count data collected during the autumn seasons of 1990–2014 from 22 ridge‐top raptor‐migration monitoring sites in the Pacific, Eastern, and Central flyways of North America. We simulated 18 different survey protocols and effort levels based on survey guidance by repeatedly drawing quasi‐random subsamples from continuously collected data in a manner that imitated the recommended protocols, comparing the number of eagles seen in simulated counts to the eagles seen in all data collected to assess the effectiveness of those protocols in correctly estimating the eagle passage rate (eagles detected per hour of counts) at each site. Multihour point counts conducted on a weekly basis were found to be ineffective at correctly estimating eagle passage both within and across years. Counts conducted in the afternoon were found to be more effective than those conducted in the morning. We demonstrate that full‐day counts, conducted weekly during the peak period of eagle passage, were much more effective at estimating eagle passage rate. Although current guidance recommends the performance of such full day counts, this result underscores their importance in preconstruction surveys at potential wind sites as an essential tactic to estimate eagle passage and risk of collision with energy infrastructure. © 2018 The Wildlife Society.
Pathologies, Actions, Ideas
Authors: Frampton Sally 
Published: December 2018

AbstractThis chapter examines the early history of ovarian surgery taking the story back to the eighteenth century. During this time, the ovary was believed to have a complex pathology, which made it an object of curiosity within the burgeoning field of morbid anatomy. Chaotic, deceptive and at times astonishing due to the enormous size they could attain, ovarian tumours were seen to defy both bodily order and medical control. These difficulties precipitated an interest among English, Scottish, French and American medical practitioners as to the possibility of finding a surgical solution to the disease. The chapter argues that it was also the relative expendability of reproductive organs, in comparison with other ‘vital’ organs, which further focused attention upon them as a potential site of surgical intervention.
Patent Concerns, Unpatentable Procedures
Authors: Frampton Sally 
Published: December 2018

AbstractBy the mid-1860s, perceptions of ovariotomy—both within the professional sphere and beyond—were undergoing a rapid turnaround. In 1865, the publication of Thomas Spencer Wells’ Diseases of the Ovaries: their Diagnosis and Treatment, in which the surgeon detailed all 114 ovariotomies he’d performed, dramatically improved the reputation of ovariotomists and signalled a major rebranding of the operation from dangerous novelty to a symbol of Victorian skill and industry. As the operation’s status ascended, those who had risked their reputation to perform it became more vocal in their claims to credit for doing so. This chapter addresses those questions of priority, credit and intellectual property which adhered to the operation during the 1860s and beyond.
On the origin and propagation of perturbations that cause shock train inherent unsteadiness
Authors: Hunt Robin L. , Gamba Mirko 
Published: December 2018

In constant area back pressured ducts, shock trains exhibit inherent unsteadiness where the shock system fluctuates about its time-averaged position despite constant bulk inflow and outflow conditions. In this work, the underlying causes of inherent unsteadiness are identified and the flow dynamics of the system is studied for a shock train in a Mach 2.0 ducted flow that is mechanically back pressured. High-speed schlieren movies and pressure measurements are collected to quantify the shock system fluctuations. Cross-spectral analysis of this data is used to identify specific perturbations, i.e. the fluid phenomena that impact the shock train motion. Key information about each perturbation is also obtained, including where it originates, what direction it travels and how it impacts each shock. Oil flow visualization and particle image velocimetry are then used to gain insight into the physical structure of perturbations and the flow phenomena that generate them. The results identify a complex, frequency-dependent dynamical system that is influenced by (i) upstream propagating acoustic waves that emanate from separation bubbles, (ii) vortices that shed from separation bubbles and convect downstream and (iii) upstream propagating acoustic waves generated in the diffuser. With this information, a scaling argument for the shock train inherent unsteadiness is presented.
Active sediment creep deformation on a deep-sea terrace in the Japan Trench
Authors: Nitta Sayaka , Kasaya Takafumi , Kawamura Kiichiro 
Published: December 2018

AbstractEighty-six new acoustic survey lines along and across the Japan Trench revealed active sediment creep deformation on a deep-sea terrace at water depths of 400–1200 m in an area of arcuate-shaped depressions that are probably associated with tectonic erosion. The most active region of creep is located on the top at the surface of the depression south of 38° N. The area of creep deformation is characterized by arcuate-shaped topographic lineaments with active folds and active normal faults stepping down trenchward. In contrast to the southern region, normal faults at the top of the depression north of 38° N cut a sedimentary sequence (Unit 1) that is acoustically transparent with continuous weak reflectors, and this is covered by the undeformed layered sediment sequence of Unit 2. Unit 2 corresponds to the period of rising sea level that extended from the latest Pleistocene to the early Holocene (14–6 ka). Thus, creep is ongoing at the top of the depression south of 38° N in the surface layer, whereas it stopped north of the depression between 14 and 6 ka. These observations might indicate that the active region jumped from north to south due to probably retrogressive sliding.
Strong but Intermittent Spatial Covariations in Tropical Land Temperature
Authors: Yang Hui , Piao Shilong , Huntingford Chris , Peng Shushi , Ciais Philippe , Chen Anping , Zhou Guiyun , Wang Xuhui , Gao Mengdi , Zscheischler Jakob 
Published: December 2018

AbstractSurface temperature variations across the tropics exhibit different levels of spatial coherence, yet this is poorly characterized. Years of high temperature anomalies occurring simultaneously across large geographical regions have the potential to adversely impact food production and societal well‐being. Using cluster analysis of correlations between extensive temperature measurements from the last six decades, we find a major change occurs in the late 1970s. Two spatial clusters merge to a single dominant one, and therefore, warmer years are experienced at the same time across most tropical land regions. Noting this change occurs at the same time as the Pacific Decadal Oscillation shifts a warm phase, we investigate this potential driver by a range of coupled ocean‐atmosphere‐land climate models. These simulations verify that stronger spatial tropical land temperature coherence tends to occur in Pacific Decadal Oscillation warm phases, although model differences exist in projections of how climate change may modulate this dependence.
Flares in open clusters with K2
Authors: Ilin Ekaterina , Schmidt Sarah J. , Davenport James R. A. , Strassmeier Klaus G. 
Published: December 2018

Context. The presence and strength of a stellar magnetic field and activity is rooted in a star’s fundamental parameters such as mass and age. Can flares serve as an accurate stellar “clock”?
Aims. To explore if we can quantify an activity-age relation in the form of a flaring-age relation, we measured trends in the flaring rates and energies for stars with different masses and ages.
Methods. We investigated the time-domain photometry provided by Kepler’s follow-up mission K2 and searched for flares in three solar metallicity open clusters with well-known ages, M 45 (0.125 Gyr), M 44 (0.63 Gyr), and M 67 (4.3 Gyr). We updated and employed the automated flare finding and analysis pipeline Appaloosa, originally designed for Kepler. We introduced a synthetic flare injection and recovery sub-routine to ascribe detection and energy recovery rates for flares in a broad energy range for each light curve.
Results. We collect a sample of 1761 stars, mostly late-K to mid-M dwarfs and found 751 flare candidates with energies ranging from 4 × 1032 erg to 6 × 1034 erg, of which 596 belong to M 45, 155 to M 44, and none to M 67. We find that flaring activity depends both on Teff, and age. But all flare frequency distributions have similar slopes with α ≈ 2.0−2.4, supporting a universal flare generation process. We discuss implications for the physical conditions under which flares occur, and how the sample’s metallicity and multiplicity affect our results.
Talcum Powder Toxicosis in Pregnancy
Authors: Pennycuff Jon , Davenport Abigail , Ellis Jane , Patberg Elizabeth , Cwiak Carrie 
Published: December 2018

Background Pica is a relatively common phenomenon in pregnancy and typically includes consumption of nontoxic substances such as earth/clay, raw starches, and ice. Occasionally, substances may be toxic or have unintended consequences.
Case A nulliparous woman presented to our facility complaining of numerous, vague symptoms that are common in pregnancy. She had multiple work-ups and an admission to our antepartum unit without clear etiology of her symptoms. Ultimately, she was diagnosed with talcum powder toxicosis secondary to talc ingestion as a coping mechanism for her anxiety, which was heightened in pregnancy.
Conclusion This case highlights the importance of screening for mental health disorders, which may be exacerbated during the peripartum period. Patients' coping mechanisms for mental health disorders may have unintended consequences.
Pain Intensity: How Press Ganey Survey Domains Correlate in Total Knee Arthroplasty Patients
Authors: Mohamed Nequesha S. , Gwam Chukwuweike U. , Etcheson Jennifer I. , Castrodad Iciar M. Dávila , Gitarts Steven L. , Jetty Avnish S. , Srour Brandon A. , Delanois Ronald E. 
Published: December 2018

AbstractDecreasing postoperative pain for total knee arthroplasty (TKA) patients has been an area of continued effort for healthcare providers. These efforts have been incentivized by legislative reform, which ties reimbursement for hospitals and providers to patient perception of care. Press Ganey (PG) surveys quantify patient satisfaction, and the “pain management” domain is thought to be the best metric for assessing pain intensity. Therefore, these responses are important, as they are used to guide further improvements in healthcare delivery. This study analyzes which PG survey domains are truly associated with pain intensity in the immediate postoperative period following TKA. We queried our PG database for all primary TKA patients between November 2012 and January 2015, yielding a total of 214 patients. Multivariate regression analysis was performed utilizing pain intensity as the dependent variable. Predictor variables included body mass index (BMI), Charlson's comorbidity index, opioid consumption, and PG survey domains. Patient ratings of “communication with doctors” (B = 58.147; p = 0.001), “responsiveness of hospital staff” (B = − 62.663; p = 0.041), “communication about medicines” (B= −45.037; p < 0.001), and “hospital environment” (B = 69.342; p = 0.017) were associated with patient pain intensity. We found survey domains, other than “pain management,” were associated with pain intensity. Efforts to improve outcomes and satisfaction should focus on staff education and communication. The current method for measuring patient satisfaction and reimbursement should be critically assessed and redesigned to better reflect true patient experiences.