bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Oxygen Reconstruction Enables Dual‐Ion Active Sites in Carbon Cathode for High Energy Density Sodium‐Ion Capacitors
Authors: Li Jie , Liu Chang , Hu Xinyu , Cai Jieming , Lian Huimin , Li Dongxiao , Zhong Biao , Deng Wentao , Hou Hongshuai , Zou Guoqiang , Ji Xiaobo 
Published: October 2024

AbstractCarbon materials are the promising cathode material for sodium‐ion capacitors (SICs) with high energy/power density, however, clarifying the evolution processes of functional groups in carbon materials and revealing their energy storage mechanisms are full of challenges. Inspired by the ancient practice of alchemy, which sought to purify Dan medicine and remove impurities through precise control of the refining temperature, the local oxygen reconstruction strategy, to alter the functional groups species in SP3‐C, is pioneeringly utilized, achieving targeted regulation of carbonyl groups with increase from 27.9 to 43.3 at%, which efficiently change the electronic structure of the carbon framework and realize the dual‐ion adsorption of Na+ and ClO4−, according well with the theoretical calculations. As expected, the obtained carbon cathode delivers a specific capacity of 145 mAh g−1, higher than that of the parent carbon material (95 mAh g−1). Impressively, the ex situ X‐ray Photoelectron Spectroscopy and in situ Raman reveals that carbonyl can act as dual‐ion active sites for Na+ and ClO4− through pseudocapacitive behavior under different voltage states. Notably, the assembled SIC using the carbonyl‐rich carbon cathode exhibits an ultrahigh energy density of 162 Wh kg−1. This work opens a novel avenue for regulating the carbonyl content of carbon materials.
Multi‐Target Peptide Nanofiber Immunotherapy Diminishes Complement Anaphylatoxin Activity in Acute Inflammation
Authors: Freire Haddad Helena , Roe Emily F. , Xie Fu Vinicius , Curvino Elizabeth J. , Collier Joel H. 
Published: October 2024

AbstractThe anaphylatoxins C3a and C5a are products of the complement cascade that play important and interrelated roles in health and disease. Both are potential targets for anti‐inflammatory active immunotherapies in which a patient's own immune system is stimulated to produce therapeutic immune responses against problematic self‐molecules. However, the complex and time‐dependent interrelations between the two molecules make dual targeting challenging. To investigate a dual‐target active immunotherapy against C3a and C5a and to systematically study the effect of varied degrees of responses against both targets, the study employed self‐assembled peptide immunogens capable of displaying a broad range of epitope compositions and Design‐of‐Experiments (DoE) approaches. Peptide nanofibers contained B‐cell epitopes of C3a and C5a in defined quantities, and intranasal immunization raised systemic and mucosal immunity against each target. In a lipopolysaccharide‐induced model of sepsis, increasing anti‐C5a responses are protective, whereas increasing anti‐C3a responses are detrimental, and survival rates are negatively correlated with anti‐C3a/anti‐C5a IgG titer ratio. This work highlights the interplay between the two molecules by making use of a modular, defined, and easily adjusted biomaterial‐based active immunotherapy platform.
Disrupting Intracellular Homeostasis by Copper‐Based Nanoinducer with Multiple Enzyme‐Mimicking Activities to Induce Disulfidptosis‐Enhanced Pyroptosis for Tumor Immunotherapy
Authors: Jin Xiao‐Kang , Zhang Shun‐Kang , Zhang Shi‐Man , Liang Jun‐Long , Yan Xiao , Lin Yan‐Tong , Meng Ran , Xu Zi‐Han , Liu Chuan‐Jun , Zhang Xian‐Zheng 
Published: October 2024

AbstractGiven the crucial role of abnormal homeostasis in tumor cells for maintaining their growth, it may be more efficient with less effort to develop anti‐tumor strategies that target multiple combined mechanisms by disrupting intracellular homeostasis. Here, a copper‐based nanoinducer (CGBH NNs) with multiple enzyme‐like activities is designed and constructed to induce disulfidptosis‐enhanced pyroptosis through disrupting multiple intracellular homeostasis for effective tumor immunotherapy. Within the tumor microenvironment (TME), CGBH NNs can disrupt intracellular glucose homeostasis and inhibit NADPH production, leading to accumulation of cystine, which further blocked the substrate and key enzyme for synthesizing glutathione. Subsequently, through cascade catalytic reactions involving enzyme activities (glutathione peroxidase‐like, glucose oxidase and peroxidase‐like activities), CGBH NNs can produce massive reactive oxygen species (ROS) and further disrupt intracellular redox homeostasis, resulting in the disulfidptosis‐enhanced pyroptosis. The tumor cells undergoing immunogenic pyroptosis can release various cytosolic contents and inflammatory factors, eliciting robust immune responses by facilitating immune cell infiltration, and reprogramming the immunosuppressive TME. After the combination with immune checkpoint blockade therapy, CGBH NNs can effectively suppress the tumor growth and prolong the survival time of tumor‐bearing mice. This work presents a novel paradigm to trigger disulfidptosis‐enhanced pyroptosis by destroying intracellular homeostasis for anti‐tumor immunotherapy.
Nanobodies Outperform Antibodies – Rapid Functionalization with Equal In Vivo Targeting Properties
Authors: Jung Carina , Fichter Michael , Oberländer Jennifer , Schunke Jenny , Bolduan Vanessa , Schneider Paul , Kang Jinhong , Koynov Kaloian , Mailänder Volker , Landfester Katharina 
Published: October 2024

AbstractHighly specific targeting of dendritic cells in vivo is crucial for the development of effective tumor nanovaccines. This group recently presented an antibody‐functionalized nanocarrier system able to maintain its targeting properties when transferred from in vitro to in vivo studies. However, producing this system requires long synthesis times and involves high expenses due to the involved site‐specific enzymatic multi‐step modification procedure of the antibody. Consequently, improving the previously proposed system is necessary in order to accelerate the development. Here, a novel system utilizing nanobodies for the targeting of dendritic cells is presented. A C‐terminal cysteine tag facilitates an easy attachment of the nanobody to the nanocarrier via a thiol‐maleimide conjugation technique. This reduces the functionalization time from several days to mere hours. Using in vitro and in vivo assays, it is shown that the optimized system possesses equal targeting properties as the antibody‐based system. As a result, nanobodies and the coupling chemistry are found to be a superior strategy for the in vivo targeting of dendritic cells when compared to antibodies, due to their rapid attachment to nanocarriers and equal targeting specificity. This would replace antibodies as the current “gold standard” of targeting moieties.
Digital Light Process 3D Printing of Magnetically Aligned Liquid Crystalline Elastomer Free–forms
Authors: Herman Jeremy A. , Telles Rodrigo , Cook Caitlyn C. , Leguizamon Samuel C. , Lewis Jennifer A. , Kaehr Bryan , White Timothy J. , Roach Devin J. 
Published: October 2024

AbstractLiquid crystalline elastomers (LCEs) are anisotropic soft materials capable of large dimensional changes when subjected to a stimulus. The magnitude and directionality of the stimuli‐induced thermomechanical response is associated with the alignment of the LCE. Recent reports detail the preparation of LCEs by additive manufacturing (AM) techniques, predominately using direct ink write printing. Another AM technique, digital light process (DLP) 3D printing, has generated significant interest as it affords LCE free‐forms with high fidelity and resolution. However, one challenge of printing LCEs using vat polymerization methods such as DLP is enforcing alignment. Here, we document the preparation of aligned, main‐chain LCEs via DLP 3D printing using a 100 mT magnetic field. Systematic examination isolates the contribution of magnetic field strength, alignment time, and build layer thickness on the degree of orientation in 3D printed LCEs. Informed by this fundamental understanding, DLP is used to print complex LCE free‐forms with through‐thickness variation in both spatial orientations. The hierarchical variation in spatial orientation within LCE free‐forms is used to produce objects that exhibit mechanical instabilities upon heating. DLP printing of aligned LCEs opens new opportunities to fabricate stimuli‐responsive materials in form factors optimized for functional use in soft robotics and energy absorption.
Polyoxometalate‐Derived Photocatalysts Enabling Progress in Hydrogen Evolution Reactions
Authors: Ren Hongyan , Wang Guangning , Chen Tingting , Wang Qian , Ren Jiahui , Pang Haijun 
Published: October 2024

AbstractPhotocatalytic water splitting is capable of converting abundant solar energy into environmentally friendly and renewable chemical energy, presenting a promising solution to alleviate the energy crisis and combat environmental pollution. The development of high‐performance photocatalysts is crucial for significantly improving the efficiency of the hydrogen evolution reaction (HER) involved. Polyoxometalate (POM)‐derived materials, known for their tunable compositions, diverse structures, electron storage/release capabilities, as well as quasi‐semiconductor photochemical properties, serve as highly efficient catalysts in sustainable photosynthesis. This comprehensive review navigates the latest advancements in the assembly strategies and HER performance of POM‐based crystalline materials. It also discusses the composite materials formed by infiltrating POM into metal‐organic frameworks (MOF) and examines the roles of transition metal compounds derived from polyoxometalates, such as sulfides and carbides, in photocatalytic HER. Emphasis is placed on the prospects for the future development of POM‐based compounds as photocatalysts, along with several strategies and outlooks that could facilitate their progress. POM‐derived materials are believed to have significant potential to enhance hydrogen production efficiency while maintaining thermal stability in HER processes.
Multimodal In‐Sensor Computing System Using Integrated Silicon Photonic Convolutional Processor
Authors: Xiao Zian , Ren Zhihao , Zhuge Yangyang , Zhang Zixuan , Zhou Jingkai , Xu Siyu , Xu Cheng , Dong Bowei , Lee Chengkuo 
Published: October 2024

AbstractPhotonic integrated circuits offer miniaturized solutions for multimodal spectroscopic sensory systems by leveraging the simultaneous interaction of light with temperature, chemicals, and biomolecules, among others. The multimodal spectroscopic sensory data is complex and has huge data volume with high redundancy, thus requiring high communication bandwidth associated with high communication power consumption to transfer the sensory data. To circumvent this high communication cost, the photonic sensor and processor are brought into intimacy and propose a photonic multimodal in‐sensor computing system using an integrated silicon photonic convolutional processor. A microring resonator crossbar array is used as the photonic processor to implement convolutional operation with 5‐bit accuracy, validated through image edge detection tasks. Further integrating the processor with a photonic spectroscopic sensor, the in situ processing of multimodal spectroscopic sensory data is demonstrated, achieving the classification of protein species of different types and concentrations at various temperatures. A classification accuracy of 97.58% across 45 different classes is achieved. The multimodal in‐sensor computing system demonstrates the feasibility of integrating photonic processors and photonic sensors to enhance the data processing capability of photonic devices at the edge.
Palladium‐Catalyzed (4+2) Annulations of Silacyclobutanes and Activated Ketones
Authors: Song Zhao‐Li , Zheng Jia‐Le , Chen Zhi‐Chao , Du Wei , Song Zhenlei , Chen Ying‐Chun 
Published: October 2024

AbstractPresented herein is a palladium‐catalyzed (4+2) annulation reaction between silacyclobutanes and activated ketones, which features advantages of operation simplicity, broad substrate scope and good functionality tolerance. A diversity of oxasilacyclohexanes were straightforwardly constructed in high yields.
Site Specific C3‐Alkenylation of Indoles Mediated by In Situ C−H Iodination
Authors: Zhao Yongli , Cao Dingsheng , Wan Jie‐Ping , Liu Yunyun 
Published: October 2024

AbstractThe C3‐alkenylation of indoles have been developed by means of a novel in situ iodination tactic which is capable of mediating the Heck coupling with alkenes. The method features specific site‐selectivity oriented by the C−I bond, high‐step efficiency without pre‐functionalization for C‐halogen bond construction, as well as the highly general tolerance to different terminal alkenes, including unactivated alkenes, acrylates, acrylic acid, vinyl sulfone as well as different vinyl functionalized natural products.
Discovery and Total Synthesis of Anhydrotuberosin as a STING Antagonist for Treating Autoimmune Diseases
Authors: Guo Fusheng , Zhang Jing , Gao Yihui , Shu Zhou , Sun Fei , Ma Jing , Zhou Xu , Li Wenyang , Mao Huawei , Lei Xiaoguang 
Published: October 2024

AbstractExcessive activation of the stimulator of the interferon gene (STING) pathway has been identified as a significant contributor to various autoimmune diseases, such as STING‐associated vasculopathy with infantile‐onset (SAVI) and inflammatory bowel disease (IBD). However, discovering effective STING antagonists for treating STING‐mediated autoimmune disorders remains challenging. Herein, we identified the natural product anhydrotuberosin (ATS) as a potent STING antagonist by a high‐throughput chemical screen and follow‐up biological validations. However, the limited supply from natural product isolation impeded the pharmacological evaluations of ATS. Accordingly, we developed a concise and scalable total synthesis of ATS in 6 steps. Enabled by total synthesis, we further extensively investigated ATS's mode of action and evaluated its therapeutic potential. Remarkably, ATS inhibits STING signaling in PBMCs derived from three SAVI patients. ATS showed decent pharmacokinetic parameters and strongly alleviated tissue inflammation in DSS‐induced IBD colitis and Trex1‐/‐ autoimmune animal models with low toxicity. Collectively, this research lays the foundation for developing novel STING antagonists as an effective therapy for autoinflammatory and autoimmune diseases.
Constructing Ag/Cu2O Interface for Efficient Neutral CO2 Electroreduction to C2H4
Authors: Wei Zongnan , Wang Wenwen , Shao Tao , Yang Shuaibing , Liu Chang , Si Duanhui , Cao Rong , Cao Minna 
Published: October 2024

AbstractNeutral CO2 electroreduction to multi‐carbons (C2+) offers a promising pathway to reduce the CO2 and energy losses originating from the carbonate formation. However, the sluggish kinetics of C−C coupling brings a significant challenge of achieving high selectivity of a single product (such as ethylene), especially at industrial‐relevant current densities (>300 mA cm−2). Here, we reported an optimized Ag‐Cu2O interfacial catalyst that exhibited C2+ Faradaic efficiency (FE) of 73.6 % at 650 mA cm−2 in a flow cell. Remarkably, it obtained FEC2H4 of 66.0 % with a partial current density of 429.1 mA cm−2, making it stand out among the reported Cu‐based electrocatalysts. In situ Raman spectra uncovered that the Ag/Cu2O interfaces enabled a high coverage of *CO around the partially reduced Cu+/Cu0 active sites. Furthermore, theoretical calculations demonstrated the enhanced CO formation and C−C coupling at the Ag/Cu2O interface. This work reported an unprecedented neutral CO2 electroreduction to C2H4 performance and provided an in‐depth comprehension of the role of the bimetallic interface.
Regulating Electric Double Layer via Self‐Assembled Monolayer for Stable Solid/Electrolyte Interphase on Mg Metal Anode
Authors: Fan Zhengqing , Zhao Wanyu , Shi Shang , Zhou Mengyuan , Li Jiayi , Liu Yuan , Pan Zhenghui , Yang Xiaowei 
Published: October 2024

AbstractModulating the cationic solvation structure with high donor‐number (DN) additive is an effective strategy to construct a stable solid electrolyte interphase (SEI) on the Mg anode, which necessitates meticulous consideration of electrolyte chemistry and substantial quantities of additives. Notably, the electric double layer (EDL) adjacent to anode is pivotal role in SEI formation yet remains understudied. In this study, we propose a novel self‐assembled monolayer (SAM) strategy by utilizing (trifluoromethyl)trimethylsilane (TFTMS, only 2 vol %, 1.4 mol %, 0.135 mol L−1), a low DN but strong Mg metal absorbability through electron‐withdrawing groups(−CF3), to modulate the complex structure of the Helmholtz absorption plane. Through dipole‐dipole interaction between the electronegative fluorine (−CF3 of TFTMS) and electropositive hydrogen (−CH3/−CH2 of solvents), TFTMS weakens solvent‐Mg2+ coordination and thus enhances anion‐Mg2+ interaction, inducing a stable and dense SEI with superior electronic insulation to realize horizontal Mg plating/stripping. Consequently, the designed electrolytes enable the symmetric cells to cycle stable for up to 1000 hours and reversible Mg plating/stripping under 5 mA cm−2, they show favorable compatibility with various cathodes. More importantly, the SAM strategy has good generality in other electrolyte systems, demonstrating a simple and effective route to promote the practical application of rechargeable magnesium battery.
Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity
Authors: Han Ermeng , Li Yu‐Qing , Wu Tun , Bai Qixia , Zhang Zhe , Yuan Jie , Liu Wei , Liu Die , Li Yiming , Wang Pingshan 
Published: October 2024

AbstractThe chirality of metal‐organic cages holds enormous potential for novel applications in diverse fields, while it is relatively rare to employ such asymmetric units for the construction of noncentrosymmetric materials. Herein, by self‐assembling the 4,4′,4′′‐nitrilotribenzoic acid (H3NBA) with bis(cyclopentadienyl)‐zirconium dichloride (Cp2ZrCl2, Cp=η5‐C5H5) in different solvent conditions, we have obtained three hierarchical packing modes of metallo‐tetrahedra with distinct spatial symmetry groups (designated as Zr‐α, Zr‐β, and Zr‐γ). Among them, Zr‐α employs a simple cubic arrangement and is a common centrosymmetric superstructure, which consists of a pair of equimolar metallo‐tetrahedra enantiomers in its unit cell. While Zr‐β results in conglomerates with spontaneous resolution without using any resolving agents, giving rise to two enantiopure entities separately (Zr‐β‐P, Zr‐β‐M). More importantly, Zr‐γ breaks the inversion center of symmetry and crystallizes into a racemic yet non‐centrosymmetric superstructure with face‐centered cubic packing mode. Based on the non‐centrosymmetric nature, the hierarchical superstructure Zr‐γ displayed good second harmonic generation activities. This work presents a successful instance wherein the reaction solvent induces the modulation of intermolecular packing mode to afford non‐centrosymmetric solid materials, which can greatly promote the development of noncentrosymmetric solid (NCS) materials.
Bio‐Ag/ZnO@MWCNTs Promoted Green Synthesis of Novel Bis‐Pyrimidothiazines: Evaluation of Biological Activity
Authors: Shahvelayati Ashraf Sadat , Rostami‐Charati Faramarz , Shirangi Hannaneh Sadat , Sfandani Seyyed Komeil Hosseini 
Published: October 2024

ABSTRACTThis work investigated the one‐pot multicomponent reactions of guanidine, isothiocyanates, and unsaturated 1,3‐dicarbonyl compounds in an aqueous media at room temperature using catalytic quantities of Ag/ZnO@MWCNTs which was produced bis‐pyrimidothiazines with high yields. This field of study uses diphenyl‐picrylhydrazine (DPPH) radical trapping to investigate the antioxidant properties of some generated bis‐pyrimidothiazines. Academic studies that are now in progress have focused on investigating the antibacterial properties of compounds that have been created. An experimental process that produced the bis‐pyrimidothiazines showed a number of noteworthy characteristics, including quick reaction kinetics, high product yields, and simple catalyst separation from the reaction mixture.
Multidimensional study of starch co‐plasticized with glycerol and isosorbide in TPS/PLA blends: Morphological, mechanical, thermal, and structural properties
Authors: Gómez‐López Rudy A. , Montilla‐Buitrago Camilo E. , Villada‐Castillo Héctor S. , Serna‐Cock Liliana 
Published: October 2024

AbstractBiodegradable blends of polylactic acid (PLA) and thermoplastic starch (TPS) co‐plasticized with glycerol (G) and isosorbide (i) in different ratios were prepared by extrusion in a single screw extruder. The G/isosorbide ratio varied within the range 27.5/2.5 to 15/15. The resulting materials were obtained through blown film extrusion and characterized using a variety of techniques. The plasticizing effect was identified through SEM and FTIR observations. In the SEM images, it was evident that most of the native crystalline structures were destructured. Furthermore, SEM observations showed phase separation of TPS and PLA in all samples, with phase dispersion differences depending on the co‐plasticizer ratio. The FTIR spectra of all TPS/PLA films showed that isosorbide caused changes in the absorption bands that suggested a reduction in the crystallinity of the native starch, agreeing with the XRD results that indicated the formation of different crystalline structures (EH type). The XRD results revealed a change in the crystal structure of the TPS phase influenced by the amount of isosorbide. Isosorbide increased tensile strength and reduced elongation due to strong interactions between the plasticizer and the starch chains through hydrogen bonds, con‐firmed by FTIR analysis. In general, it was established that isosorbide and G co‐plasticization, with small amounts of isosorbide (up to a ratio of 25:5 G/isosorbide), can be employed as an effective plasticizer without significantly affecting the tensile mechanical properties.
The intersection of anatomy and spirituality
Authors: Balta Joy Y. 
Published: October 2024

AbstractThe intersection of anatomy and spirituality offers a profound exploration into how the physical and spiritual aspects of our being interrelate, enhancing our understanding of wholeness. These domains are often seen as distinct, with anatomy rooted in the tangible study of the human body, while spirituality is considered intangible and deeply personal. However, as our understanding of both fields has evolved, a more integrative approach is emerging, recognizing that the physical and spiritual are not separate but interconnected aspects of human experience. In this unique special issue, we explore the diverse ways in which spirituality influences the field of anatomy. To provide a comprehensive perspective, the issue is organized into three sections. The first section examines how spirituality shapes students' learning experiences in anatomy. The second section focuses on the role of religious beliefs in body donation practices. Finally, the third section considers the interplay between spirituality and culture, and how this dynamic has influenced the discipline of anatomy over time. This special issue emphasizes the connection between anatomy and spirituality, bridging the divide between the physical and spiritual dimensions of educators, students, body donors, and community members. More needs to be done in the future to embrace the connection between anatomy and spirituality and build upon it to advance our discipline.