bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using A Facebook Group to Facilitate Faculty-Student Interactions during Preclinical Medical Education: A Retrospective Survey Analysis
Authors: Henry David S. , Wessinger William D , Meena Nikhil K. , Payakachat Nalin , Gardner Jerad M. , Rhee Sung W 
Published: August 2019

Abstract
Background: Strong learner-teacher relationships are associated with more successful learning outcomes. With shortened modular curricula and increased availability of online resources, fostering faculty interaction with preclinical medical students has become more challenging. We sought to enhance learner-teacher relationships by engaging in discussion with preclinical medical students in their own online space. Methods: We utilized a closed Facebook discussion group, where faculty and students voluntarily joined in informal discussions and shared announcements related to their courses. The closed discussion group allowed only participating students and faculty to see others’ posts within the group. This provided a platform to freely interact within the confines of the group while maintaining privacy for the personal Facebook accounts of both faculty and students. We utilized the discussion group through 3 separate organ system-based modules for 14 weeks. Afterward, students were asked to complete a voluntary online survey about their experience. Results: 94.1% (160/170) of enrolled second-year medical students joined the voluntary FB discussion group. There were 214 posts, 628 comments, and 4166 reactions in this discussion group during the three modules. Of the students in the group, 74.4% (119/160) responded to the online survey. Overall, students strongly agreed that the Facebook discussion group fostered better rapport with faculty, helped content learning, and improved emotional well-being. Also, they felt more comfortable seeking academic help after using the discussion group. They reported a slight preference for Facebook over email as a medium for asking questions, but no preference for either as a medium for distributing announcements. Students overwhelmingly recommended that the discussion group should be continued in future years. Conclusion: The Facebook discussion group was a free, efficient, and effective method of cultivating the learner-teacher relationship with the preclinical medical students, resulting in reported enhancement in learning and morale.
Molecular characterization of strong biofilm producing MDR, XDR and PDR Pseudomonas aeruginosa isolated from a tertiary care hospital in South India
Authors: Manivannan Bhavani , Pachipulusu Chanakya , Khamari Balaram , Datta Chandreyee , Lama Manmath , Raman Sai Suguna , Bulagonda Eswarappa Pradeep 
Published: August 2019

Abstract
Background : Pseudomonas aeruginosa is an opportunistic, gram negative bacterium that causes serious infections, especially among immunocompromised patients. An unusually high incidence of nosocomial P. aeruginosa infections was observed among patients hospitalized at Sri Sathya Sai Institute of Higher Medical Sciences, Puttaparthi, India, between 2014 November and 2015 February. Some of the patients being treated for a variety of cardiac and urological disorders in the Cardiothoracic and Vascular Surgery - Intensive Care Unit (CTVS-ICU) and Urology ward were found infected with P. aeruginosa . Active surveillance and environmental sampling revealed the presence of two additional MDR P. aeruginosa in the tap waters of CTVS-ICU. Based on the Antibiotic sensitivity pattern, fourteen P. aeruginosa MDR (n=7), XDR (n=6) and PDR (n=1) isolates (inclusive of the two tap water isolates) were shortlisted for additional investigations. These isolates were characterized for antibiotic sensitivity, biofilm production, minimum biofilm inhibitory concentration (MBIC), presence of antibiotic resistance genes, efflux pumps, and integrons.
Results : Mutations in gyr A, gyr B, par C, mex R, nfx B, mex B and mex F genes were correlated to enhanced antibiotic resistance. Notably, the isolates were also found to harbor integrons and blaNDM-1. Pulsed Field Gel Electrophoresis (PFGE) and Random Amplified Polymorphic DNA (RAPD) based phylogenetic analyses grouped the clinical isolates into three distinct ward specific clusters, while the tap water isolates were grouped into a separate cluster. Detection of nosocomial P. aeruginosa in the CTVS-ICU and urology ward triggered the activation of enhanced surveillance and infection control measures to contain and eliminate P. aeruginosa infections.
Conclusions : Multiple clones of P. aeruginosa are prevalent in the study center. Hence, continuous screening and identification of potential reservoirs is absolutely essential to control the spread of drug resistant P. aeruginosa infections.
Anti-pathogenic efficacy of biogenic silver nanoparticles through adherence and biofilm inhibition in multidrug resistant ESKAPE pathogens
Authors: Khan Mohd Hashim , Unnikrishnan Sneha , Ramalingam Karthikeyan 
Published: August 2019

Abstract
Background

The current study aimed to produce AgNPs through a biogenic approach and assessed for their significant anti-pathogenic activities against multi-drug resistant ESKAPE pathogens. The biogenic AgNPs were synthesized through non-toxic manner and characterized by using UV-vis, XRD, DLS, TGA-DTA, FTIR, SEM along with EDX and UHRTEM were used to determine the absorption spectra, shape, size, thermal behaviour, functional groups, morphology, elemental constituents and defined particle size distribution profile, respectively. The AgNPs were evaluated for their anti-pathogenic effects against eleven strains of multi drug resistant ESKAPE pathogens by growth inhibition, biofilm adhesion, growth kinetics and Live/dead assays.Results

The inhibitory range of AgNPs concentration was investigated as higher zones at escalating concentration (50 to 200 µg/ml). The growth kinetics of inhibition of all tested pathogens occurred after 4 hrs of treatment with AgNPs. Adherence assay exhibited highest inhibition in E. faecium (MCC 2763), P. aeruginosa (MTCC 1688) and E. species (MCC 2296) at 100µg/ml of AgNPs. The exposure of AgNPs increased the dead cell and consequently reduced cells density with AgNPs comparable with the effect of commercial antibiotics. The selected pathogens were found more sensitive to AgNPs than Cefotaxime/AgNO3 with the statistically significant (P < 0.05).Conclusion

The emergence of drug resistance in ESKAPE pathogens are the extending reason for nosocomial infections, limiting the choice of antibiotics. Nanomaterials have been considered potential agents to prevent infections. Therefore, present study showed the broad spectrum potential and anti-pathogenic potency of biogenic AgNPs as an alternative to conventional antimicrobial agents.
Spiritualistic Humanistic Communication Strategy on Learning Aqidah Akhlaq at Madrasah Ibtidaiyah Negeri 1 Yogyakarta, Indonesia
Authors: Prastowo Andi , Latief Muhammad Jamroh 
Published: August 2019

<p><em>This study discusses the communication strategy in learning Aqidah Akhlaq to foster humanistic values and spiritualistic intelligence of learners in religious Elementary School Madrasah Ibtidaiyah Negeri (MIN) 1 Yogyakarta. This study used a qualitative approach with case study method. Data were collected by in-depth interview, observation, and documentation, then analysed by interactive model. The results of this study revealed that communication strategy to cultivate the values of humanistic spirituality in MIN 1 Yogyakarta includes 3 three kinds: teachers as a compelling speaker, teachers as less effective preachers, and teachers as moderators.</em></p><p><strong><br /></strong></p><p><strong>Abstrak</strong></p><p>Penelitian ini membahas strategi komunikasi dalam pembelajaran Aqidah Akhlaq untuk menumbuhkan nilai-nilai humanistik dan kecerdasan spiritualistik peserta didik di Sekolah Dasar Agama Madrasah Ibtidaiyah Negeri (MIN) 1 Yogyakarta. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Data dikumpulkan dengan wawancara mendalam, observasi, dan dokumentasi, kemudian dianalisis dengan model interaktif. Hasil penelitian ini mengungkapkan bahwa strategi komunikasi untuk menumbuhkan nilai-nilai spiritualitas humanistik di MIN 1 Yogyakarta meliputi 3 tiga jenis: guru sebagai pembicara yang meyakinkan, guru sebagai pengkhotbah yang kurang efektif, dan guru sebagai moderator.</p><p><strong> </strong></p>
Multicultural Value in the Traditional Islamic Boarding School, Bina Insan Mulia (BIMA), Cirebon, Indonesia
Authors: Nurhayati Eti , Nurhidayah Yayah 
Published: August 2019

<p class="KEYWORD">Multicultural Education in Islamic Boarding Schools teaches tolerance and openness in carrying out activities of daily living. This research was conducted at the Bina Insan Mulia (BIMA) boarding school using descriptive qualitative methods, as well as data collection techniques by interviewing, observing, documenting studies, and FGDs. The conclusions of this study are: (1) The values of Multicultural Islamic Education implemented at the BIMA Islamic Boarding School are sourced from books / books taught to students / students such as the book of Hadith al-Arba'in Nawawiyah, Safinah al-Najah, Fath al-Qarib , Ta'lim al-Mutaa'llim, Taysir al-Khalaq, and Riyadh al-Saliheen; (2) The application of multicultural values includes openness, humanity, tolerance, mutual assistance, justice, equality, brotherhood.</p><p class="KEYWORD"> </p><p class="KEYWORD"><strong>Abstrak</strong></p><p class="ABSTRACT">Pendidikan Multikultural di Pondok pesantren mengajarkan toleransi dan keterbukaan dalam melaksanakan aktifitas hidup sehari-hari. Penelitian ini dilakukan di pondok pesantren Bina Insan Mulia (BIMA) dengan menggunakan metode deskriptif kualitatif, serta teknik pengumpulan data dengan wawancara, observasi, studi dokumentasi, dan FGD. Kesimpulan penelitian ini adalah: (1) Nilai-nilai Pendidikan Islam Multikultural yang diterapkan di Pondok pesantren BIMA bersumber dari kitab / buku yang diajarkan kepada murid / Santri seperti kitab Hadits al-Arba'in Nawawiyah, Safinah al-Najah, Fath al-Qarib, Ta'lim al-Mutaa'llim, Taysir al-Khalaq, dan Riyadh al-Shalihin; (2) Penerapan nilai-nilai multikultural tersebut meliputi keterbukaan, kemanusiaan, toleransi, saling membantu, keadilan, kesetaraan, persaudaraan.</p><p class="KEYWORD"> </p>
Ahmad Dahlan’s Perspective about the Model of Modern Integration Islamic Education
Authors: Fanani Ahwan 
Published: August 2019

<p>Ahmad Dahlan made a breakthrough in Islamic Education in the Early 20<sup>th </sup>Century. He was not only educated in a traditional environment, but also influenced by the modernist movement in Egypt, especially Abduh and Rashid Ridla. This article aims to describe the approach of modern Islamic education by Ahmad Dahlan. This writing uses the socio-historical approach. The results show that Dahlan renewed Islamic Education by integrating Islamic subjects into the public school curriculum and vice versa. The project covers aspects of curriculum, methods, and institutions. Integration projects are more practical and in line with projects undertaken by Ismail Raj'i al-Faruqi, Naquib al-Attas, and Amin Abdullah. The modern Islamic education model by Ahmad Dahlan is relevant to current Islamic education.</p><p><strong> </strong></p><p><strong>Abstrak</strong></p><p>Ahmad Dahlan melakukan terobosan dalam Pendidikan Islam di Awal abad 20. Beliau tidak hanya dididik di lingkungan tradisional, tetapi juga dipengaruhi oleh gerakan modernis di Mesir, terutama Abduh dan Rashid Ridla. Artikel ini bertujuan untuk menggambarkan pendekatan pendidikan Islam modern oleh Ahmad Dahlan. Penulisan ini menggunakan pendekatan sosial-sejarah. Hasilnya menunjukkan bahwa Dahlan memperbarui Pendidikan Islam dengan mengintegrasikan mata pelajaran Islam ke dalam kurikulum sekolah umum dan sebaliknya. Proyeknya mencakup aspek kurikulum, metode, dan kelembagaan. Proyek integrasi lebih bersifat praktek dan sejalan dengan proyek yang dilakukan oleh Ismail Raj'i al-Faruqi, Naquib al-Attas, dan Amin Abdullah. Model pendidikan Islam modern oleh Ahmad Dahlan relevan dengan Pendidikan Islam saat ini.</p><p> </p>
Liberating People; Critical Pedagogy on the Revolutionary Thought of Hassan Hanafi
Authors: Khasri M. Rodinal Khair 
Published: August 2019

<pre>The researcher observed the dimension of critical pedagogy in the context of Hassan Hanafi revolutionary thought. He was very good founding the fundamental thought in theology of liberation named Left Islam. This research used a literature study and historical-factual method to analyze the dimension of critical pedagogy on Hassan Hanafi revolutionary thought. The result of this research was new understanding about critical pedagogy dimension on Hassan Hanafi thought. <em>First.</em> Dehumanization in the context of education is inseparable from the influence of Western cultural imperialism. <em>Second,</em> The critical pedagogy found in Hassan Hanafi's thoughts is a pedagogy that aims to eliminate the destructive nature caused by the one-dimensional view that results in educational disorientation from the true educational goal of liberating people.</pre><p> </p><p><strong>Abstrak</strong></p><pre>Artikel ini mempresentasikan hasil penelitian terhadap pemikiran revolusioner Hassan Hanafi sehingga ditemukan dimensi pedagogi kritisnya. Hassan Hanafi merupakan sosok pemikir Islam yang sangat baik di dalam membangun pemikiran-pemikiran fundamental di dalam konteks teologi pembebasan, serta yang paling terkenal ia sebut dengan istilah “Kiri Islam”. Penelitian ini termasuk dalam klasifikasi studi literatur dengan metode historis-faktual di dalam menganalisis dimensi pedagogi kritis di dalam pemikiran Hassan Hanafi. Hasil penelitian ini adalah pemahaman baru tentang dimensi pedagogi kritis di dalam pemikiran Hassan Hanafi. <em>Pertama,</em> dehumanisasi dalam konteks pendidikan adalah akibat dari pengaruh imperialisme budaya Barat.<em> Kedua</em>, pedagogi kritis Hasan Hanafi fokus pada upaya membangkitkan kesadaran eksistensial di tengah beragam permasalahan yang terjadi di masyarakat. Pedagogi kritis yang ditemukan di dalam pemikiran Hassan Hanafi merupakan pedagogi yang bertujuan untuk menghilangkan hal yang bersifat destruktif yang disebabkan oleh pandangan berdimensi-satu yang mengakibatkan disorientasi pendidikan dari tujuan pendidikan yang sesungguhnya yaitu memerdekakan manusia.</pre><p> </p>
Comparison of microbial and physicochemical behavior of expanded granular sludge bed system during methylparaben and triclosan removal
Authors: Castrillon Laura , Londoño Yudy Andrea , Pino Nancy J. , Peñuela Gustavo A. 
Published: August 2019

Abstract
Methylparaben and triclosan are antimicrobial agents widely used as preservatives in a variety of personal care and pharmaceutical products. Wastewater is considered the main source of these compounds in the environment. Expanded granular sludge bed (EGSB) reactors are a high rate technology for wastewater treatment based on biological processes and have been shown to be efficient in removing different types of compounds; however, little is known about the effect of contaminants such as methylparaben and triclosan on their behavior and effectiveness. In this study, we evaluate and compare the microbial and physicochemical behavior of EGSB systems during methylparaben and triclosan removal. The presence of different concentrations of pollutants had an influence on the cluster organization of microbial communities, especially bacteria. However, this did not affect the stability and performance of the EGSB systems. The banding patterns of the denaturing gradient gel electrophoresis of archaea demonstrated the constant presence and abundance of Methanosaeta concilii throughout all stages of operation, showing that this microorganism played a fundamental role in the stability of the reactors for the production of methane. The type of compound and its concentration influenced the expression of the mcrA and ACAs genes; however, these changes did not alter the stability and performance of the EGSB systems.
Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Mutations in the Occurrence and Treatment of Pancreatic Cancer
Authors: Zhu Ziying , Xiao Saisong , Hao Haojie , Hou Qian , Fu Xiaobing 
Published: August 2019

:
Pancreatic cancer is a highly malignant tumor with a 5-year survival rate of less than 6%, and
incidence increasing year by year globally. Pancreatic cancer has a poor prognosis and a high recurrence
rate, almost the same as the death rate. However, the available effective prevention and treatment measures
for pancreatic cancer are still limited. The genome variation is one of the main reasons for the development
of pancreatic cancer. In recent years, with the development of gene sequencing technology,
in-depth research on pancreatic cancer gene mutation presents that a growing number of genetic mutations
are confirmed to be in a close relationship with invasion and metastasis of pancreatic cancer.
Among them, KRAS mutation is a special one. Therefore, it is particularly important to understand the
mechanism of the KRAS mutation in the occurrence and development of pancreatic cancer, and to explore
the method of its transformation into clinical tumor molecular targeted treatment sites, to further
improve the therapeutic effect on pancreatic cancer. Therefore, to better design chemical drugs, this review
based on the biological functions of KRAS, summarized the types of KRAS mutations and their
relationship with pancreatic cancer and included the downstream signaling pathway Raf-MEK-ERK,
PI3K-AKT, RalGDS-Ral of KRAS and the current medicinal treatment methods for KRAS mutations.
Moreover, drug screening and clinical treatment for KRAS mutated cell and animal models of pancreatic
cancer are also reviewed along with the prospect of targeted medicinal chemistry therapy for precision
treatment of pancreatic cancer in the future.
The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.
Authors: Mahdavi Saman , Amiradalat Morteza , Babashpour Marzieh , Sheikhlooei Hosein , Miransari Mohammad 
Published: August 2019

Background:
The antioxidant, anticarcinogenic, and antimicrobial activities of Verbascum
Thapsus L., known as great mullein, (an important medicinal plant containing different biochemical
compounds including sesquiterpenes, flavonoids, saponins and lignins) were determined.
There is not much data, to our knowledge, in this respect.

Methods:
The antioxidant activities of V. Thapsus were investigated by the DPPH (2, 2- diphenyl-
1-picrylhydrazyl) method. Using GC-MS, the presence of different anticarcinogenic products including
1-hexzanol (2.11%), 2-hexene (1.95%), etc. was determined in the ethanolic extract of V.
Thapsus. The antimicrobial activities of V. Thapsus were determined by the minimum inhibiting
concentration (MIC) and minimum bactericidal concentration (MBC) methods using the Grampositive
and -negative bacterial strains.

Results:
The least concentration of V. Thapsus L. ethanolic extract (50 mg/l) resulted in only
21.26% inhibition of DPPH free radicals, however, the concentrations of 300 mg/l resulted in almost
the highest inhibition (91.31%) of DPPH free radicals. The antioxidant activities of synthesized
antioxidant BHT at the concentration of 300 mg/l or higher were similar to the antioxidant
activities of V. Thapsus L. ethanolic extract. Both the isolated and the standard Gram-negative bacterial
strains were more tolerant to the V. Thapsus ethanolic extract, compared with the Grampositive
bacterial strains. Bacillus cereus was the most sensitive bacterial strain among the tested
bacterial strains.

Conclusion:
The medicinal plant V. Thapsus L. can be used for the treatment of different diseases,
such as cancer and infectious diseases.
The Interplay Between Asthma and Other Diseases: Role of Ca2+/cAMP Signalling
Authors: Bergantin Leandro B. 
Published: August 2019

Objective:
Asthma is correlated with a higher risk of manifesting other diseases, including
hypertension, diabetes, obesity, psychiatric and neurological diseases, and cancer. Therefore, revealing
this interplay between asthma and these illnesses may provide novel insights into their pathogenesis.

Results:
It is highly debated that dysregulation of Ca2+ homeostasis is involved in the pathogenesis of
these maladies. Not surprisingly, calcium (Ca2+) channel blockers (CCBs), classically used as antihypertensive
medicines, have been demonstrating off-label effects such as alleviating asthma symptoms,
in addition to antidiabetic, antiobesity, anticancer and antineurodegenerative effects. Our studies
about Ca2+/cAMP signalling may shed some new light on this field.

Conclusion:
Thus, considering that asthma and associated illnesses such as hypertension, diabetes,
obesity, cancer and neurodegenerative diseases have become highly prevalent medical problems in the
world, the comprehension of this interplay between asthma and other disorders could improve drug
therapy.
ASSESSMENT OF RELIABILITY AND VITALITY OF SYSTEMS TAKING INTO ACCOUNT THE INTERRELATION OF ELEMENTS WITH SEISMIC EXPOSURE
Authors: Abakarov A. J. , Gasanov R. G. 
Published: August 2019

ObjectivesThe aim of the study is to develop a model for assessing the reliability of frame systems, taking into account the redistribution of forces between vertical structures when plastic hinges are formed in them from horizontal seismic effects.MethodThe research method is based on the analysis of the schemes of mechanisms for the transition of frame systems to limit states, as well as probability theory, random processes and system reliability.ResultsBased on the analysis of the paths of transition of statically indefinable frame systems to failure states due to the formation of plastic hinges at the junction points of the posts with crossbars, a block diagram of the system elements connection has been developed, presented as a separate redundancy scheme. The expressions for estimating the probabilities of switching off the conditional elements in the computational model and transitions of the system, both to the backup and to the failure states are presented. Expressions are proposed for assessing the survivability of frame systems with a decrease in static indeterminacy due to the formation of plastic hinges in structures. The calculation example is given.ConclusionThe proposed model for assessing reliability allows, in contrast to the parametric model, to evaluate the reliability of structures with regard to the redistribution of effort in structures with damage accumulated in racks in the form of plastic hinges, and to identify reliability reserves embedded in statically indeterminable systems under strong seismic effects.
CALCULATION OF STRESSED-DEFORMED STATE OF THREE-LAYER PIPES OF SYMMETRIC AND ASYMMETRIC STRUCTURE
Authors: Abakarov M. S. , Vishtalov R. I. , Muselemov H. M. , Ustarkhanov O. M. 
Published: August 2019

Objectives This article discusses the evaluation of the effectiveness of three-layer pipes of a symmetric and asymmetric structure. For this, the stress-strain state of three-layer pipes of different materials under the influence of internal pressure is investigated. Pipeline structures today occupy important positions in the infrastructures of many countries. Trunk structures affect the economy, industry. Every year, new safety requirements are added to the reliability indicators of these structures.Method The calculation is carried out by numerical methods, namely using the finite element method (FEM), implemented in the LIRA PC.Result The calculation of the pipes is performed, on the load from the transported medium, applied to the inner contour of the pipe. Moreover, for three-layer pipes of all variants, Nx tensile stresses along the generatrix, Ny ring tensile stresses and Txy shear stresses in the xy plane were determined. Isopoles of tensile and shear stresses are given.Conclusion The numerical results showed that the use of less deforming material as a material for the manufacture of asymmetric bearing layers leads to a redistribution of stresses in the bearing layers and aggregate, and this must be taken into account when designing three-layer pipes.