bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing physical activity in cardiac patients who report hopelessness: Feasibility testing of an intervention
Authors: Dunn Susan L , Robbins Lorraine B , Smith Sandi W , Ranganathan Rajiv , DeVon Holli A , Collins Eileen G , Hong Hyokyoung G , Tintle Nathan L 
Published: November 2018

Objective: Hopelessness is present in 27% of patients with ischaemic heart disease (IHD), can persist for 12 months and is associated with lack of physical activity (PA). No interventions have been tested to increase PA in IHD patients who report hopelessness. This study evaluated the feasibility of conducting a randomised controlled trial to investigate the effectiveness of the Heart Up! intervention, designed to reduce hopelessness through enhanced PA in IHD patients. It was hypothesised that increased PA would be identified in the intervention group. Setting: Patients were recruited from a large teaching hospital in the Midwestern USA. Data collection occurred in the patient’s home at 1 and 8 weeks after hospital discharge. Methods: A three-group design was used. Eligible patients were randomised to (1) motivational social support (MSS) from a nurse, (2) MSS from a nurse with social support from a significant other support (SOS) or (3) control. MSS-only and MSS-SOS recipients received motivational interviewing followed by 6 weeks of social support text messages from a nurse. MSS-SOS participants additionally received social support text messages from a significant other. Control participants received the usual care. Feasibility outcomes included recruitment and retention rates, patient acceptability and patient satisfaction. An accelerometer measured PA. Results: Of the 156 patients screened for the study, 43 met the inclusion criteria. Of eligible patients, 69.8% ( n = 30) enrolled and 67% ( n = 20) completed the study. Patients in the MSS and MSS-SOS groups expressed satisfaction with the intervention components (86% with motivational interviewing, 77% with nurse texts and 100% with significant other texts). Although differences were not statistically significant, a medium effect size for change in PA was identified in the MSS-SOS group compared to the other two groups. Conclusion: Study findings demonstrate the feasibility of the Heart Up! intervention and support testing its efficacy in a randomised controlled trial.
Sweet Solutions for Analgesia in Neonates in China: A Systematic Review and Meta-Analysis
Authors: Huang Rui-Rui , Xie Ri-Hua , Wen Shi Wu , Chen Shao-Lin , She Qin , Liu Yan-Nan , Harrison Denise 
Published: November 2018

Introduction High-quality synthesized evidence of sweet taste analgesia in neonates exists. However, Chinese databases have never been included in previous systematic reviews of sweet solutions for procedural pain. Objective To conduct a systematic review of Chinese literature evaluating analgesic effects of sweet solutions for neonates. Data sources: Wang Fang, China National Knowledge Infrastructure and Chinese Biomedical Literature Database. Data extraction and analysis: Two authors screened studies for inclusion and conducted risk of bias ratings and data extraction. A third author resolved any conflicts. Meta-analyses were performed using RevMan 5.2 software, on mean differences in pain outcomes using random effects models. Results Thirty-one trials (4999 neonates) were included; 26 trials used glucose, 4 used sucrose, and 1 trial evaluated both solutions. Sweet solutions reduced standardized mean pain scores (n = 21 studies; −1.68, 95% confidence interval −2.08, −1.27) and cry duration (n = 6 studies; −25.60, 95% confidence interval −36.47, −14.72 s) but not heart rate change (n = 7 studies; −17.64, 95% confidence interval −52.71, 17.43). No included studies cited the previously published systematic reviews of sweet solutions. Conclusions This systematic review of Chinese databases showed the same results as previously published systematic reviews. No trials included in this review cited the English systematic reviews, highlighting a parallel research agenda.
Balloon Angioplasty Versus Bailout Stenting for Isolated Chronic Total Occlusions in the Popliteal Artery
Authors: Elens Maxime , Verhelst Robert , Mastrobuoni Stefano , Bosiers Michel J. , Possoz Julien , Lacroix Valérie , Astarci Parla 
Published: November 2018

Aims: Stenting of the popliteal artery (PA) is generally considered inappropriate due to the high mechanical stress and bending of the artery during knee flexion. Nevertheless, vessel recoil remains problematic following angioplasty procedure for chronic total occlusions (CTOs) and adjunctive stenting may be required. The purpose of this study is to compare balloon angioplasty alone versus bailout stenting for isolated CTO of the PA. Materials and Methods: Between March 2012 and October 2016, 43 patients were treated with percutaneous transluminal angioplasty with balloon alone (PTA, n = 16) or bailout stenting percutaneous transluminal angioplasty and stenting (PTAS, n = 27) for de novo CTO of PA. There was no statistically significant difference between both groups with regard to patient demographics and lesions characteristics (calcification severity and lesion length). The median lesion lengths were 67 mm (39.5-78.5) in the PTA group and 94 mm (50-114) in the PTAS group ( p = 0.14). The primary outcome measure was primary patency; secondary outcomes were technical success, primary assisted patency, major amputation, and increased Rutherford classification. Results: Technical success rate was 37% and 96.3% in the PTA and PTAS groups, respectively. There was no statistical difference in 12-month primary patency rate (65.8% versus 58.7%; p = 0.15) and primary assisted patency at 12 months (75.2 versus 69.2; p = 0.47) between the 2 groups. Freedom from target lesion revascularization at 12 months was not significantly different, with 85.7% and 81.6% ( p = 0.2) in the PTA and PTAS groups, respectively. One amputation occurred in the PTA group. Conclusion: This small cohort suggests that stenting as a bailout procedure in CTO of the PA provides similar results to successful balloon angioplasty. Stenting should only be performed after suboptimal balloon angioplasty with vessel recoil. Due to the large lost to follow-up, strong evidence of a therapy over the other cannot be formulated. Larger studies with longer and stronger follow-up are needed to confirm those results.
The History of the Development of Melt Blowing Technology
Authors: McCulloch John G. 
Published: November 2018

Almost a half century ago development efforts were initiated by very different entities, in widely different locations, to demonstrate one step processes to convert polymer to web: • Major fiber producers (DuPont, Freudenberg, Monsanto) began work on converting polymer (PE, PET, Nylon) into continuous “cold drawn” filaments and integrating the conversion of these filaments into a random-laid bonded nonwoven fabric. • An oil company (Exxon), building on the earlier work (1950's) of the Naval Research Labs to produce fine fibers, began work on converting their recently commercialized PP polymer into discontinuous, or continuous, “hot drawn” filaments and integrating these filaments into a random-laid self bonded nonwoven web having average fiber sizes 2–5 microns (fine fibered webs) to 100+ fibers (coarse fibered webs). As a result of these early development efforts, three different, but related melt spinning nonwoven processes have achieved significant commercial importance, with tremendous benefits to consumers worldwide: • Spunbond process • Melt blowing process • Flash spinning process This presentation will summarize the development of the melt blowing process from conceptualization to current state-of-the-art. Important product, process and equipment developments are detailed in the 50 year growth of the melt blowing process from a laboratory concept to a 125 million pound a year U.S. and Canadian commercial business and substantial additional worldwide consumption. Today, spunbond and melt blown processes are used for approximately 54% of the total 18.6 million square yards U.S. nonwoven market.
Glenohumeral fusion in adults with sequelae of obstetrical brachial plexus injury: a report of eight cases
Authors: Belkheyar Zoubir , Belkacem Djeffel Amar , Cambon-Binder Adeline 
Published: November 2018

The purpose of this study was to assess the outcomes of glenohumeral fusion performed in adulthood in patients with poor recovery after obstetric brachial plexus injury. We reviewed eight patients with obstetrical brachial plexus injury who had undergone shoulder arthrodesis. The mean age was 28 years (range 16 to 55). All of the patients had active periscapular and elbow flexor muscles. At an average follow-up of 20 months, the active range of abduction and external rotation of the affected shoulder was 67° (range 50° to 85°) and 21° (range 0° to 40°), respectively. All of the patients were satisfied with the outcome of the intervention. Fusion was obtained between 3 and 6 months, and none of the patients experienced residual pain. Shoulder fusion improved the active shoulder abduction and external rotation in adults with residual obstetrical brachial plexus paralysis. Level of evidence: IV
Pre-hospital risk assessment in suspected non-ST-elevation acute coronary syndrome: A prospective observational study
Authors: van Dongen Dominique N , Tolsma Rudolf T , Fokkert Marion J , Badings Erik A , van der Sluis Aize , Slingerland Robbert J , van ’t Hof Arnoud WJ , Ottervanger Jan Paul 
Published: November 2018

Background: Pre-hospital risk stratification of non-ST-elevation acute coronary syndrome (NSTE-ACS) by the complete HEART score has not yet been assessed. We investigated whether pre-hospital risk stratification of patients with suspected NSTE-ACS using the HEART score is accurate in predicting major adverse cardiac events (MACE). Methods: This is a prospective observational study, including 700 patients with suspected NSTE-ACS. Risk stratification was performed by ambulance paramedics, using the HEART score; low risk was defined as HEART score ⩽ 3. Primary endpoint was occurrence of MACE within 45 days after inclusion. Secondary endpoint was myocardial infarction or death. Results: A total of 172 patients (24.6%) were stratified as low risk and 528 patients (75.4%) as intermediate to high risk. Mean age was 53.9 years in the low risk group and 66.7 years in the intermediate to high risk group ( p<0.001), 50% were male in the low risk group versus 60% in the intermediate to high risk group ( p=0.026). MACE occurred in five patients in the low risk group (2.9%) and in 111 (21.0%) patients at intermediate or high risk ( p<0.001). There were no deaths in the low risk group and the occurrence of acute myocardial infarction in this group was 1.2%. In the high risk group six patients died (1.1%) and 76 patients had myocardial infarction (14.4%). Conclusions: In suspected NSTE-ACS, pre-hospital risk stratification by ambulance paramedics, including troponin measurement, is accurate in differentiating between low and intermediate to high risk. Future studies should investigate whether transportation of low risk patients to a hospital can be avoided, and whether high risk patients benefit from immediate transfer to a hospital with early coronary angiography possibilities.
Fascin-1 Is a Novel Prognostic Biomarker Associated With Tumor Invasiveness in Adrenocortical Carcinoma
Authors: Poli Giada , Ruggiero Carmen , Cantini Giulia , Canu Letizia , Baroni Gianna , Armignacco Roberta , Jouinot Anne , Santi Raffaella , Ercolino Tonino , Ragazzon Bruno , Assie Guillaume , Mannelli Massimo , Nesi Gabriella , Lalli Enzo , Luconi Michaela 
Published: November 2018

Abstract

Context
Novel tumor markers are urgently needed to better stratify adrenocortical cancer (ACC) patients and improve therapies for this aggressive neoplasm.

Objective
To assess the diagnostic and prognostic value of the actin-bundling protein fascin-1 (FSCN1) in adrenocortical tumors.

Design, Setting and Participants
A local series of 37 malignant/37 benign adrenocortical tumors at Careggi University Hospital and two independent validation ACC cohorts (Cochin, TCGA) from the European Network for the Study of Adrenal Tumors were studied.

Main Outcome Measures
FSCN1 expression was quantified by immunohistochemistry, Western blot and quantitative RT-PCR in ACC specimens; overall and disease-free survival associated with FSCN1 expression were assessed by Kaplan-Meier analysis and compared with that of Ki67 labeling index and tumor stage.

Results
Despite the low diagnostic power, in the Florence ACC series, FSCN1 immunohistochemical detection appeared as an independent prognostic factor, also refining results obtained with staging and Ki67 labeling index. The robust prognostic power of FSCN1 levels was further confirmed in two independent ACC cohorts. A positive correlation was found between FSCN1 and steroidogenic factor-1 (SF-1), with a substantially higher expression of both factors in ACCs at advanced stages and with at least one of the three Weiss score parameters associated with invasiveness. Moreover, we demonstrated FSCN1 role in promoting cell invasion in a human ACC cell line only in the case of increased SF-1 dosage.

Conclusions
These findings show that FSCN1 is a novel independent prognostic marker in ACC and may serve as a potential therapeutic target to block tumor spread.
Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility
Authors: Chavez Daniela R. , Snow Angela K. , Smith Joseph R. , Stanfield Gillian M. 
Published: November 2018

ABSTRACT
The development of highly differentiated sperm cells that are specialized for navigating to and fusing with an oocyte is essential for sexual reproduction. As a major part of differentiation, sperm undergo extensive post-meiotic maturation en route to the oocyte. This is regulated largely by soma-derived cues. In Caenorhabditis elegans, this process is called sperm activation, and it transforms immotile spermatids into migratory fertilization-competent cells. Here, we show that the negative regulator of sperm activation, SWM-1, is produced in an unexpected cell type: body wall muscle. SWM-1 is secreted into the body cavity and enters the gonad; there, it is present with its likely target, TRY-5, a spermiogenesis activator. We show that, in addition to SWM-1, the somatic gonad and body fluid can exchange other factors, suggesting that soma-germ line transfer could affect other reproductive processes. In addition, we show that SWM-1 may have a separate role in the sperm migratory environment, to which it is contributed by both males and hermaphrodites. These findings reveal that late stages in gamete differentiation can be regulated at the whole-organism level by broadly secreted factors.
This article has an associated ‘The people behind the papers’ interview.
The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1
Authors: Song Jiasheng , Li Wanwan , Zhao Haihong , Gao Lulu , Fan Yuning , Zhou Shutang 
Published: November 2018

ABSTRACT
Krüppel-homolog 1 (Kr-h1), a zinc-finger transcription factor, inhibits larval metamorphosis and promotes adult reproduction by transducing juvenile hormone (JH). Although the transcriptional regulation of Kr-h1 has been extensively studied, little is known about its regulation at the post-transcriptional level. Using the migratory locust Locusta migratoria as a model system, we report here that the microRNAs let-7 and miR-278 bound to the Kr-h1 coding sequence and downregulated its expression. Application of let-7 and miR-278 mimics (agomiRs) significantly reduced the level of Kr-h1 transcripts, resulting in partially precocious metamorphosis in nymphs as well as markedly decreased yolk protein precursors, arrested ovarian development and blocked oocyte maturation in adults. Moreover, the expression of let-7 and miR-278 was repressed by JH, constituting a regulatory loop of JH signaling. This study thus reveals a previously unknown regulatory mechanism whereby JH suppresses the expression of let-7 and miR-278, which, together with JH induction of Kr-h1 transcription, prevents the precocious metamorphosis of nymphs and stimulates the reproduction of adult females. These results advance our understanding of the coordination of JH and miRNA regulation in insect development.
Laboratory validation and field usability assessment of a point-of-care test for serum bilirubin levels in neonates in a tropical setting
Authors: Thielemans Laurence , Hashmi Ahmar , Priscilla Dah Dah , Kho Paw Moo , Pimolsorntong Tekel , Ngerseng Thatsanun , Van Overmeire Bart , Proux Stephane , Nosten François , McGready Rose , Carrara Verena I. , Bancone Germana 
Published: November 2018

Background: Screening and monitoring serum bilirubin (SBR) in neonates is crucial to prevent neonatal hyperbilirubinemia (NH)-associated morbidity and mortality worldwide. A lack of resources is often a barrier for measuring SBR in developing countries. Reliable, cost-effective, easy to use point-of-care (POC) SBR tests are needed. This study aimed to evaluate the technical accuracy and usability of the Bilistick System (BS), a new bilirubin POC test, in a tropical setting. Methods: This was a mixed-methods study, including laboratory validation of the BS, direct observation of technical procedures as performed by the midwives and midwives’ assessment of the device’s easiness of use through focus group discussions (FGD) and a self-administered questionnaire. The study was conducted in a field clinic of the Shoklo Malaria Research Unit along the Thailand-Myanmar border between January and December 2017. Results: A total of 173 samples were tested at a median age of 4 days. BS generated an error message—providing no SBR readout—in 48.6% of the tests performed. For the tests that yielded a result, the correlation coefficient (95% CI) between BS and routine laboratory bilirubinometer SBR was 0.87 (0.77-0.93). The accuracy decreased with increasing haematocrit and at higher humidity (≥75%). Direct observation of the operators using the device and analysis of the focus group discussions and questionnaires indicated that the BS was considered easy to use and required limited training. Conclusions: This evaluation showed that the BS, in its current formulation, does not provide reliable results for measuring SBR in a tropical, low-resource setting but has acceptable usability features.
Promoting Meaningful Encounters as a Way to Enhance Intercultural Competences
Authors: Carreño Bolivar Laura Lucia 
Published: November 2018

This article aims at sharing an experience in which an Intercultural Competences based course was taught to university level students in a Colombian higher education institution. Topics such as minority groups, national identity and racism were included in the course syllabus in order to raise students´ awareness regarding the importance of interculturality. Students´ posts and survey responses are shared in order to portray their perceptions regarding the course and its influence on the development of intercultural competences.
Community-Based Approaches to Foreign Language Education
Authors: Comber Barbara 
Published: November 2018

Learning how to recognise and make student and community assets the subject of curriculum is at the core of teachers’ designs and enactments of critical and inclusive pedagogies. However, this era of globalisation and standardisation, where education is increasingly seen as a commodity that underscores economic competitiveness, has made space for local knowledge production, hard to find. Knowing how to incorporate community problems in school-based student-led inquiries, whilst meeting authorised learning outcomes, is also challenging. At the same time there are particular pressures on language teachers where states extol the benefits of English, or another foreign language literacy for global competitiveness. Yet, educational researchers and teacher educators know the potential power of working with students’ assets and motivations to enhance language and literacy learning in classrooms. Community based approaches to language education in various places in Latin America are explored in this issue with contributions from teacher-researchers, collaborative teams, teacher educators and university-based researchers.
Context matters: Professionalization of campaign posters from Adenauer to Merkel
Authors: Venema Niklas , Steffan Dennis 
Published: November 2018

Abstract
This study examines the professionalization of political communication by focusing on changes to campaign posters for Bundestag elections over the course of five eras of German post-war history. We conducted a quantitative content analysis of both visual and textual elements of campaign posters (N = 1,857) in the period from 1949 to 2017 with regard to personalization, de-ideologization, and negative campaigning. The study revealed differences related to the five eras. Following the early conservative governments (1949–1969), high levels of personalization and ideologization first became defining features of election campaigns during the social-liberal era (1969–1982). After the Kohl era (1982–1998), these trends have occurred again since the Schröder era (1998–2005) and have been reinforced in the Merkel era (2005–2017). Furthermore, we found neither a clear upward nor a downward trend for negative campaigning. Overall, our study demonstrated that political parties adapt their communication strategies to the context of the respective election.
Stoichiometry of equations through the Inverse de Donder relation
Authors: Mousavi Aliyar 
Published: November 2018

Abstract
The stoichiometry of equations was revisited in light of the Law of Conservation of Matter at an atomic, elemental level. For a balanced chemical equation following the simplest general model aA → bB, the fact that

a
b

=

n
A

n
B

${a \over b} = {{{n_A}} \over {{n_B}}}$

, where nA
is the number of moles of A consumed and nB
is the number of moles of B produced in the reaction during the experiment, was used to address the de Donder relation, introduced by Theophile de Donder (1873–1957). While crediting the Belgian scientist for pointing out that “the reaction-ratio method” may be utilized for stoichiometry, the inverse de Donder relation was applied to problems in reaction stoichiometry. Several examples were used to show that the latter relation can be used to form proportions in order to rapidly solve such stoichiometry problems and to do so with fundamental chemical understanding. Educators in general chemistry were encouraged to teach the discussed method in their courses.
The cinematic mode in fiction
Authors: Bellardi Marco 
Published: November 2018

AbstractThis article focuses on the imitation of film form in cinematic novels and short stories on the level of narrative discourse and introduces the concept of ‘para-cinematic narrator’. The author compares the temporality expressed by verbal tenses in literature and the temporality expressed through film semiosis. The connection between film and literary fiction is explored in terms of foreground and background narrative style. It is argued that the articulation of narrative foreground and background – i. e. the “narrative relief” (Weinrich 1971) – in film form tends to favour the foreground style, and that such narrative relief is ‘flattened’ due to the “monstrative” quality (Gaudreault 2009) of the medium. This flattening is remediated in strongly cinematised fiction and conveyed through the use of verbal tenses. The imitation of montage and specific cinematic techniques is conceived, consequently, as a separate feature that can integrate into this remediated, para-cinematic temporality. Finally, the author recalls the concept of “mode” in genre theory (Fowler 2002), which describes a “distillation” of traits from one genre to another. With the category of cinematic mode the remediation of basic traits from film to literary fiction can be framed in terms of genre-related discourses.