bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as a predictor of disease-free survival in breast cancer: A cross-sectional study
Authors: Al-Bairmany Yaala S. , Aqabi Adil S. , Al-Hasnawi Farah H. , Al-Aawad Alaa S. 
Published: March 2019

Background: The relationship between neutrophil-lymphocyte ratio (NLR) with outcome is a complex issue. A high NLR reflects systemic inflammation. This study aimed to estimate the relationship between NLR, and platelet-lymphocyte ratio (PLR) in disease-free survival (DFS). Methods: This was a cross-sectional study in which we reviewed the patient files of 102 patients with breast cancer treated at the Babylon Oncology Center from January 2009 to September 2014, who had follow-up for at least 36 months. The following data were collected from patient files: age, diagnosis date, date of recurrence and/or metastasis, follow-up, histological tumor type, tumor size, node metastasis stage, histological differentiation degree, estrogen and/or progesterone receptor expression, HER2 neu status, and metastasis site. Results: The mean age of patients was 50.4 ± 11.7 years and lowest period of follow up was 40 months. Longest DFS was 62 months, with 5 years DFS in 52.5% of patients. Stage N0 was associated with a significantly higher DFS compared to stage N1. Isolated local recurrence was seen in 15% of patients and combined local recurrences with distant metastasis was observed 37%. NLR had the highest discrimination ability to predict recurrence and distant metastasis. Conclusion: An increase in NLR was associated with poor DFS, and it can therefore be a predictive and prognostic factor. NLR’s established prediction model warrants further investigation.
Coordinating with a “Problem Solver”
Authors: Glazer Jacob , Rubinstein Ariel 
Published: March 2019

A “problem solver” (PS) is an agent who when interacting with other agents does not “put himself in their shoes” but rather chooses a best response to a uniform distribution over all possible configurations consistent with the information he receives about the other agents’ moves. We demonstrate the special features of a PS by analyzing a modified coordination game. In the first stage, each of the other participants—who are treated as conventional players—chooses a location. The PS then receives some partial information about their moves and chooses his location. The PS wishes to coordinate with any one of the conventional players and they wish to coordinate with him but not with each other. Equilibria are characterized and shown to have different properties than those of Nash equilibria when the PS is treated as a conventional player. This paper was accepted by Joshua Gans, business strategy.
Initial experience of a rapid-access ultrasound imaging service for inflammatory bowel disease
Authors: Grunshaw Nigel D 
Published: March 2019

Background: Ultrasound has a number of advantages as an investigative modality in inflammatory bowel disease (IBD), particularly with regard to the accessibility of the test and immediate availability of report, although it is less widely used in the UK. Method: A retrospective review was performed by a consultant radiologist of the initial 6 months of a rapid-access combined ultrasound-imaging clinic, run with the assistance of an IBD nurse. Results: The review demonstrated that 69% of examinations were performed and reported in under 14 days. As a result of ultrasound, 43% of patients underwent change in management, with 35% requiring either immediate clinical review or follow up within 1 week. Conclusion: Expansion of the role of the IBD nurse, together with wider adoption of ultrasound as a primary imaging modality has the potential to significantly improve patient management in Crohn's disease and ulcerative colitis.
The Existence of the Doctrine of Severability and Competence-Competence under the Constellation of Indonesian Arbitration Law
Authors: Sutanto Marko Cahya 
Published: March 2019

Abstract
When the parties choose Indonesia as the seat of arbitration, one might inquire whether Indonesian legal system is in conformity with the doctrines that developed in the field of international commercial arbitration. To fulfill that purpose, this paper discusses: (1) under the umbrella of severability doctrine, the agreement to arbitrate or arbitration clause is not classified as an accessory to the principal contract; and (2) the competence-competence doctrine is not adopted perfectly on the account of the question whether the tribunal can decide on its own jurisdiction is not explicitly touched.
The Use of Anthropological Approach in Municipal Strategic Planning
Authors: Liukinevičienė Laima , Vičienė Jovita 
Published: March 2019

Abstract
The article presents a theoretical concept of an anthropological approach in strategic municipal management as well as work of researchers in development of anthropological methodology in strategic management. Pursuing the aim to develop theoretical discourse, the results of the performed qualitative research which confirm the actuality of an anthropological approach and application possibilities in municipal strategic planning are presented.
Performative Strategien des memento mori
Authors: Schmidt Antje 
Published: March 2019

Abstract

In einer gesteigerten Form der Memento-mori-Dichtung des Barock wurde die menschliche Sterblichkeit durch den Einsatz performativer Strategien für die Zeitgenoss*innen bereits zu Lebzeiten erfahrbar. So waren mahnende und tröstende Tote, die scheinbar direkt aus dem Jenseits zu den Lebenden sprechen, in Begräbnisgedichten und Grabinschriften allgegenwärtig. Ebenso waren Gedichte und Sterbelieder verbreitet, in denen der Sterbeakt performativ durchlebt werden konnte. In der Gegenwart, die sich nach Norbert Elias durch eine Verdrängung der menschlichen Vergänglichkeit zugunsten von Unsterblichkeitsphantasien, und somit einer Vermeidung von Erfahrungen mit der Vergänglichkeit, auszeichnet, gestalten einige deutschsprachige Lyriker*innen moderne Variationen dieses gesteigerten memento mori. In den untersuchten Gedichten von Özlem Özgül Dündar und Günter Kunert werden durch performative Verfahren Konfrontationen mit der eigenen Endlichkeit inszeniert, welche als moderne, säkulare Vergänglichkeitsmahnungen verstanden werden können.
Aufzeichnung von Vergänglichkeit
Authors: Benthien Claudia 
Published: March 2019

Abstract

Dieser Beitrag untersucht eine Videoinstallation des belgischen Künstlers Koen Theys, die er als Remediation einer monumentalen skulpturalen Installation angefertigt hat. Beide Werke sind extensive zeitgenössische Auseinandersetzungen mit dem frühneuzeitlichen Vanitas-Stillleben. Sie reflektieren und exponieren dessen mediale Form und ästhetische Eigenzeit auf potenzierte Weise, indem der Prozess des ‚Aufzeichnens von Vergänglichkeit’ sowohl erlebbar gemacht als auch ironisch kommentiert wird. Wesentliche Bezüge sind dabei die kunsthistorische Tradition und die Kunstkritik der Gegenwart.
Enden und Verfliegen
Authors: Sykora Katharina 
Published: March 2019

AbstractDieser Beitrag nimmt drei Perspektiven ein. Zunächst geht es um Ikonografien der Fliege und des Totenkopfes innerhalb der Stilllebenmalerei seit der Frühen Neuzeit und um die doppelte Vergänglichkeitsmetaphorik, die aus der Kombination von Motiv und Genre resultiert. Zudem geht die Untersuchung der Frage nach, welche medialen und semantischen Verschiebungen bei dem Übertrag dieser dichten Vanitas-Konfiguration in die Fotografie entstehen. Mein Fokus liegt dabei auf den zeitgenössischen Arbeiten der amerikanischen Fotografin Paulette Tavormina und ihren zwischen 2013 und 2015 entstandenen Re-Inszenierungen historischer Stillleben-Darstellungen. Aus der motiv- und gattungsspezifischen sowie der medialen Perspektive ergeben sich schließlich Fragestellungen, die das Thema Vanitas in seiner moralisierenden wie auch zeitlichen Dimension thematisieren. So stelle ich zwei konträre Formen der Temporalität in den Stillleben mit Fliege und Totenkopf zur Diskussion: das Enden und das Sich-Verflüchtigen.
Sound Monuments
Authors: Schulze Holger 
Published: March 2019

Abstract

Dieser Beitrag untersucht drei Beispiele zur Überwindung von Vergänglichkeit und Endlichkeit, einer Inversion der Vanitas-Motivik, vor allem in den Klangkünsten: Wie ist es technisch möglich und kulturell zu bewerkstelligen, dem Verwehen von Klängen entgegenzuwirken? Die transhistorische Übertragungstheorie der médiologie von Régis Debray wird hierbei genutzt, um Formen und Strategien zur ‚ewigen Übertragung’ jeweils näher zu bestimmen. Ausgehend von Edisons Bewerbung des Phonographen als eines Hilfsmittels für hörbare Testamente von Verstorbenen wird die Aufführung von John Cages ORGAN 2/ASLSP in Halberstadt, das Vorhaben einer Millennium Clock der Long Now Foundation von Stewart Brand und Brian Eno sowie die Pressung der kremierten Asche eines Verstorbenen in einer Vinylschallplatte durch die Firma Andvinyly untersucht.
En camino hacia el olvido
Authors: Gómez-Montero Javier 
Published: March 2019

AbstractMarías’ Romane setzen die kontingente Verfasstheit großstädtischen Lebens in Szene, indem sie das Zeitbewusstsein der Figuren in ein Spannungsverhältnis zur Unausweichlichkeit des – oft plötzlichen – Todes setzen, und dabei die Ambivalenz von Ordnung und Chaos, von Freiheit und Emanzipation in Indifferenz und Beliebigkeit überführen. Sie spiegeln heutige Formen ausgeprägter Individualität in der Großstadt, für die Vanitas zur Erscheinungsweise der als kontingent erfahrenen Selbst- und Welterfahrung wird. Der RomanMorgen in der Schlacht denk an michthematisiert solche Ambivalenzen der Kontingenz in unterschiedlichen Figurenkonstellationen. Nicht einmal die Möglichkeiten der libidinösen Befriedigung greifen noch, wie Marías’ RomanDie sterblich Verliebtenbestätigt. Vielmehr werden Konfigurationen der Vanitas in den skizzierten Rahmen rekontextualisiert, wodurch sich ein Schwinden (difuminación) von Identität, eine Aushöhlung des Subjekts, vollzieht.
Sommes-nous François?
Authors: Wodianka Stephanie 
Published: March 2019

Abstract

Vergänglichkeitsthematisierungen sind in den Romanen Houellebecqs omnipräsent. Doch in welchen Kontexten erscheinen sie, was ist ihre Funktion, und inwiefern sind sie mit barocken Vanitas-Szenarien vergleichbar? Im Zentrum des Aufsatzes steht die Frage, inwiefern die Vanitas-Thematisierung bei Houellebecq im Zusammenhang steht mit einer Statuszuschreibung an die Literatur – und welche Konsequenzen daraus für das Bedeutungspotential seiner Romane abzuleiten sind. Das Zusammenspiel von Vanitas-Szenarien im Werk und Vanitas-Performanz des Autors jenseits seines Werkes lässt gerade vor dem Hintergrund der frühen poetologischen Überlegungen in Gegen das Leben, gegen die Welt (1991) ein Literaturverständnis Houellebecqs hervortreten, das im politischen Sinne höchst zweifelhaft ist. Unterwerfung (2015) erweist sich als postmoderne Erbauungsliteratur, die ihren Leser irritiert mit der Frage zurücklässt, ob er sich von François emanzipieren sollte – oder ob er einfach nur liest.
Long-Lifetime and Low Latency Data Aggregation Scheduling for Wireless Sensor Network
Authors: Gayathri Easwaran , Vanitha Mohanraj , Mangayarkarasi Ramaiah , Sakthivel Ramachandran 
Published: March 2019

Abstract
Wireless Sensor Networks contain an incredible number of hubs with limited registering, detecting, and wireless communication capacities. These systems have been utilized as a part of a wide zone of utilizations, such as human services, contamination checking, and target-following frameworks. The dynamic clustering of sensors into bunches is a prevalent procedure to expand the system lifetime and increment adaptability. To accomplish this, in this article the sensor hubs are adjusted to ensure a long lifetime and the activities are arranged into rounds that use fixed time intervals. In the first phase, a clustering topology is found, and a group head is picked in view of the outstanding energy level. Then the cluster head screens the network energy threshold value to identify the energy drain rate of all its cluster members. In the second stage, the Long-Lifetime and Low-Latency Data Aggregation Scheduling method is used. This scheduling method assigns schedule openings to group part information parcels. Here, congestion occurrence is completely kept away from the scenario. In the third stage, an Energy-Efficient Distributed Schedule–based convention is used to keep up greatest residual energy level over the network. The experimental outcome shows the steps proposed in this article ensure an increase in the network lifetime and decrease in the energy utilization.
Prediction and Analysis of Abrasive Water Jet Machining Performance on Hybrid Composite
Authors: Vigneshwaran S. , Uthayakumar M. , Arumugaprabu V. 
Published: March 2019

Abstract
Hybrid polymer composites have been used in various applications because of their superior characteristics. Conventional cutting techniques in these materials produce poor quality machining because of fiber delamination and surface damage. It is also challenging to produce shapes and cuts in polymer composite materials through conventional machining. Abrasive water jet machining (AWJM) may be suitable for producing quality cuts by controlled machining process. This article investigated the AWJM of red mud–filled sisal polyester hybrid composite. The second order regression model was developed for material removal rate (MRR) and kerf taper (KT) through the experimental data. The developed model predicted the MRR and KT with minimum error at 95 % confidence level. The MRR of the hybrid composite was influenced highly by transverse speed (83.56 %) whereas the KT was influenced mostly by standoff distance (SOD, 45.66 %). Scanning electron microscope (SEM) analysis on the cut surface helps to understand the failure mechanism on AWJM.
Influence of Surface Finish on Small Punch Testing of 9Cr Eurofer-97 Steel
Authors: Richardson M. D. , Connolly S. , Gorley M. , Wynne B. P. , Surrey E. 
Published: March 2019

Abstract
This study investigated the effect of surface finish on the deformation behavior of Eurofer-97 steel during room-temperature small punch testing. The surface finish of specimens was varied from coarse to fine (ranging from P240-grit silicon carbide paper to a polished finish using 0.06-μm colloidal silica). Testing was conducted on 8-mm diameter by 0.5-mm-thick disks using a 1-mm-radius punch head. No significant change was observed in the elastic-plastic transition load, maximum load, displacement at maximum load, or displacement at failure. Similarly, in all cases, failure occurred in a ductile manner, yielding a dimpled fracture surface. Although friction and surface defects may influence the output of small punch tests, the effect of altering the specimen surface finish alone was negligible in this case, indicating this is not a dominant factor in small punch testing.
Residual Heterozygosity and Epistatic Interactions Underlie the Complex Genetic Architecture of Yield in Diploid Potato
Authors: Marand Alexandre P , Jansky Shelley H , Gage Joseph L , Hamernik Andy J , de Leon Natalia , Jiang Jiming 
Published: March 2019

Abstract
Marand et al. use a high-resolution recombination map to dissect the genetic components of yield in diploid potato. Regions of recalcitrant heterozygosity in the inbred parent co-localized with elevated recombination rates, signatures of selection, and tissue-specific gene expression...
Deconvolution of the genetic architecture underlying yield is critical for understanding bases of genetic gain in species of agronomic importance. To dissect the genetic components of yield in potato, we adopted a reference-based recombination map composed of four segregating alleles from an interspecific pseudotestcross F1 potato population (n = 90). Approximately 1.5 million short nucleotide variants were utilized during map construction, resulting in unprecedented resolution for an F1 population, estimated by a median bin length of 146 kb and 11 genes per bin. Regression models uncovered 14 quantitative trait loci (QTL) underpinning yield, average tuber weight, and tubers produced per plant in a population exhibiting a striking 332% average midparent-value heterosis. Nearly 80% of yield-associated QTL were epistatic, and contained between 0 and 44 annotated genes. We found that approximately one-half of epistatic QTL overlap regions of residual heterozygosity identified in the inbred parental parent (M6). Genomic regions recalcitrant to inbreeding were associated with an increased density of genes, many of which demonstrated signatures of selection and floral tissue specificity. Dissection of the genome-wide additive and dominance values for yield and yield components indicated a widespread prevalence of dominance contributions in this population, enriched at QTL and regions of residual heterozygosity. Finally, the effects of short nucleotide variants and patterns of gene expression were determined for all genes underlying yield-associated QTL, exposing several promising candidate genes for future investigation.
Competencia cultural de enfermeras en salud pública con población indígena
Authors: Orozco Castillo Magda Liliana , López-Díaz Alba Lucero 
Published: March 2019

Objetivo: identificar elementos de competencia cultural (CC) en las enfermeras en salud pública (ESP) cuando cuidan a población indígena emberá-chamí.Metodología: etnografía interpretativa con observación participante y entrevistas en profundidad a diez colaboradores.Análisis de datos basado en la propuesta de Leininger con apoyo de los programas ATLAS.ti y Excel.Resultados: el patrón cultural permite identificar la capacidad de las esp para analizar su propia cultura, conocer, comprender e interactuar con la cultura del indígena y mediar a través de comunicación caracterizada por empatía, adaptación del lenguaje verbal y no verbal que evidencian respeto por la singularidad indígena, en un contexto de armonía con laspolíticas institucionales basadas en la cultura indígena.Conclusión: la CC de esp es un proceso amplio, tanto de ESP con la comunidad como de la articulación con políticasinstitucionales para atender la cosmovisión indígena.
O acompanhante do paciente oncológico em fase terminal: percepção do técnico de enfermagem
Authors: Bernardes Juliana Felipelli , Nolasco Frederico Francisco , Jardim Alessandra Silva Lima , Cunha Genilton Rodrigues , Takeshita Isabela Mie , Barroso Renata Adriana de Araújo 
Published: March 2019

Objetivo: compreender a percepção dos técnicos de enfermagem em relação aos acompanhantes dos pacientes oncológicos em fase terminal.Metodologia: trata-se de uma pesquisa descritivo-exploratória de natureza qualitativa, desenvolvida em um hospital referência para o tratamento do câncer em Belo Horizonte, Minas Gerais. A coleta de dados ocorreu entre os meses de setembro e outubro de 2016. Utilizou-se a Análise de Conteúdo fundamentada em Bardin para a avaliação das entrevistas.Resultados: a partir da análise das entrevistas, emergiram duas categorias empíricas: O conviver cotidiano do técnico de enfermagem e o acompanhante do paciente oncológico em fase terminal e Fatores dificultadores da interação da enfermagem com os acompanhantes, focando-se na interação dos profissionais com o acompanhante e os fatores de conflito entre as partes.Conclusão: foi evidenciada a importância do acompanhante pelo técnico de enfermagem nesse processo de terminalidade, na medida em que podem proporcionar segurança e acolhimento ao paciente. No entanto, a ausência de uma comunicação adequada entre os acompanhantes e o profissional foi o fator preponderante na geração de conflitos. A enfermagem requer, por parte da instituição assim como do acompanhante, de espaços nos quais possam expressar suas angústias e anseios, fazendo que esse percurso seja um momento de acolhimento e de criação de vínculos entre os envolvidos.
Qualidade de vida no trabalho e a ergonomia como fator de influência na produtividade
Authors: Rorato Caroline , Estender Antonio Carlos 
Published: March 2019

Este artigo objetiva demonstrar como a ergonomia pode melhorar significativamente a eficiência, produtividade e a prática de tarefas com mais conforto, segurança e saúde nos postos de trabalho e na vida dos colaboradores das organizações envolvendo a relação do homem com o ambiente e as necessidades de qualidade, de produtividade e de redução de custos para a organização, mantendo a motivação e resultando em inúmeros benefícios. Visa também solucionar problemas, no caso, como os fatores ergonômicos podem trazer benefícios tanto à saúde do trabalhador quanto a produtividade da empresa. Com o objetivo de melhorar a eficiência organizacional, como a produtividade, realizando estudo de caso, entrevistas para levantar dados relevantes a respeito de como a ergonomia pode ser um fator importante para um local de trabalho saudável e para um bom andamento na produtividade da organização. Foram analisados as condições de trabalho e os sintomas mais frequentes que o trabalhador possa apresentar, pois esses fatores são sintomas de um ambiente de trabalho não ergonômico e que pode trazer prejuízos tanto à saúde do trabalhador quanto a produtividade da empresa.
Clinical Management of Adverse Events Associated with Lorlatinib
Authors: Bauer Todd M. , Felip Enriqueta , Solomon Benjamin J. , Thurm Holger , Peltz Gerson , Chioda Marc D. , Shaw Alice T. 
Published: March 2019

Abstract

Lorlatinib is a novel, highly potent, brain-penetrant, third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI), which has broad-spectrum potency against most known resistance mutations that can develop during treatment with crizotinib and second-generation ALK TKIs. The safety profile of lorlatinib was established based on 295 patients who had received the recommended dose of lorlatinib 100 mg once daily. Adverse events associated with lorlatinib are primarily mild to moderate in severity, with hypercholesterolemia (82.4%), hypertriglyceridemia (60.7%), edema (51.2%), peripheral neuropathy (43.7%), and central nervous system effects (39.7%) among the most frequently reported. These can be effectively managed with dose modification and/or standard supportive medical therapy, as indicated by a low incidence of permanent discontinuations due to adverse reactions. Most patients (81.0%) received at least one lipid-lowering agent. Prescription of supportive therapy should also consider the potential for drug-drug interactions with lorlatinib via engagement of specific CYP450 enzymes. This article summarizes the clinical experience from lorlatinib phase I investigators and was generated from discussion and review of the clinical study protocol and database to provide an expert consensus opinion on the management of the key adverse reactions reported with lorlatinib, including hyperlipidemia, central nervous system effects, weight increase, edema, peripheral neuropathy, and gastrointestinal effects. Overall, lorlatinib 100 mg once daily has a unique safety profile to be considered when prescribed, based on the recent U.S. Food and Drug Administration approval, for the treatment of patients with ALK-positive metastatic non-small cell lung cancer previously treated with a second-generation ALK TKI.