bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis
Authors: Rosenow Tim , Mok L. Clara , Turkovic Lidija , Berry Luke J. , Sly Peter D. , Ranganathan Sarath , Tiddens Harm A.W.M. , Stick Stephen M. 
Published: April 2019

IntroductionPulmonary inflammation and infection are important clinical and prognostic markers of lung disease in cystic fibrosis (CF). However, whether in young children they are transient findings or have cumulative, long-term impacts on respiratory health is largely unknown. We aimed to determine whether theirrepeateddetection has a deleterious effect on structural lung disease.MethodsAll patients aged <6 years with annual computed tomography (CT) and bronchoalveolar lavage (BAL) were included. Structural lung disease on CT (%Disease) was determined using the PRAGMA-CF (Perth–Rotterdam Annotated Grid Morphometric Analysis for CF) method. The number of times free neutrophil elastase (NE) and infection were detected in BAL were counted, to determine cumulative BAL history. Linear mixed model analysis, accounting for repeat visits and adjusted for age, was used to determine associations.Results265 children (683 scans) were included for analysis, with BAL history comprising 1161 visits. %Disease was significantly associated with the number of prior NE (0.31, 95% CI 0.09–0.54; p=0.007) but not infection (0.23, 95% CI −0.01–0.47; p=0.060) detections. Reference equations were determined.ConclusionsPulmonary inflammation in surveillance BAL has a cumulative effect on structural lung disease extent, more so than infection. This provides a strong rationale for therapies aimed at reducing inflammation in young children.
Pulmonary arterial pressure at rest and during exercise in chronic mountain sickness: a meta-analysis
Authors: Soria Rodrigo , Egger Matthias , Scherrer Urs , Bender Nicole , Rimoldi Stefano F. 
Published: April 2019

Up to 10% of the more than 140 million high-altitude dwellers worldwide suffer from chronic mountain sickness (CMS). Patients suffering from this debilitating problem often display increased pulmonary arterial pressure (PAP), which may contribute to exercise intolerance and right heart failure. However, there is little information on the usual PAP in these patients.We systematically reviewed and meta-analysed all data published in English or Spanish until June 2018 on echocardiographic estimations of PAP at rest and during mild exercise in CMS patients.Nine studies comprising 287 participants fulfilled the inclusion criteria. At rest, the point estimate from meta-analysis of the mean systolic PAP was 27.9 mmHg (95% CI 26.3–29.6 mmHg). These values are 11% (+2.7 mmHg) higher than those previously meta-analysed in apparently healthy high-altitude dwellers. During mild exercise (50 W) the difference in mean systolic PAP between patients and high-altitude dwellers was markedly more accentuated (48.3versus36.3 mmHg) than at rest.These findings indicate that in patients with CMS PAP is moderately increased at rest, but markedly increased during mild exercise, which will be common with activities of daily living.
Bone Marrow Adiposity: Basic and Clinical Implications
Authors: Sebo Zachary L , Rendina-Ruedy Elizabeth , Ables Gene P , Lindskog Dieter M , Rodeheffer Matthew S , Fazeli Pouneh K , Horowitz Mark C 
Published: April 2019

AbstractThe presence of adipocytes in mammalian bone marrow (BM) has been recognized histologically for decades, yet, until recently, these cells have received little attention from the research community. Advancements in mouse transgenics and imaging methods, particularly in the last 10 years, have permitted more detailed examinations of marrow adipocytes than ever before and yielded data that show these cells are critical regulators of the BM microenvironment and whole-body metabolism. Indeed, marrow adipocytes are anatomically and functionally separate from brown, beige, and classic white adipocytes. Thus, areas of BM space populated by adipocytes can be considered distinct fat depots and are collectively referred to as marrow adipose tissue (MAT) in this review. In the proceeding text, we focus on the developmental origin and physiologic functions of MAT. We also discuss the signals that cause the accumulation and loss of marrow adipocytes and the ability of these cells to regulate other cell lineages in the BM. Last, we consider roles for MAT in human physiology and disease.
Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse
Authors: Velte Ellen K. , Niedenberger Bryan A. , Serra Nicholas D. , Singh Anukriti , Roa-DeLaCruz Lorena , Hermann Brian P. , Geyer Christopher B. 
Published: April 2019

ABSTRACT
In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA). Here, we sought to uncover elusive mechanisms regulating a key switch fundamental to spermatogonial fate: the capacity of spermatogonia to respond to RA. Using the developing mouse testis as a model, we found that spermatogonia and precursor prospermatogonia exhibit a heterogeneous capacity to respond to RA with at least two underlying causes. First, progenitor spermatogonia are prevented from responding to RA by catabolic activity of cytochrome P450 family 26 enzymes. Second, a smaller subset of undifferentiated spermatogonia enriched for SSCs exhibit catabolism-independent RA insensitivity. Moreover, for the first time, we observed that precursor prospermatogonia are heterogeneous and comprise subpopulations that exhibit the same differential RA responsiveness found in neonatal spermatogonia. We propose a novel model by which mammalian prospermatogonial and spermatogonial fates are regulated by their intrinsic capacity to respond (or not) to the differentiation signal provided by RA before, and concurrent with, the initiation of spermatogenesis.
Interactive Virtual Reality Reduces Quadriceps Pain during High-Intensity Cycling
Authors: WENDER CARLY L. A. , AHN SUN JOO , O’CONNOR PATRICK J. 
Published: April 2019

ABSTRACT

Purpose
Brief, high-intensity cycling is popular because physiological benefits accrue with a short workout time, but burning pain in the quadriceps is a potential barrier to engaging in this type of exercise. Virtual reality (VR) can temporarily decrease pain, but its effect on muscle pain during high-intensity exercise is unknown. The primary purpose of this experiment was to test whether adding interactive VR (I-VR) to high-intensity cycling could reduce quadriceps pain or improve performance.

Methods
Ninety-four adults who were physically active in their leisure time and age 18 to 29 yr completed three 30-s sprint interval cycling trials at a high resistance (0.085- and 0.075-kg resistance to the flywheel per kilogram body weight for men and women, respectively). In this randomized between-subject experiment, participants cycled while wearing a head-mounted display and viewing either (i) a dynamically changing cityscape perceived as interactively cycling through a virtual city (I-VR group) or (ii) a static picture of the cityscape with instructions to mentally imagine cycling through that city (static VR/motor imagery control group).

Results
Sphericity-adjusted 2 × 3 (group–time) ANOVA revealed a significant group–time interaction (F = 4.568; df = 1.499, 133.301; η
p
2 = 0.047, P = 0.021) for pain intensity. With I-VR, pain intensities were 13.3% (mean, 4.60 vs 5.31; d = 0.28) and 11.8% (mean, 5.68 vs 6.44; d = 0.27) lower at sprint trials 2 and 3, respectively. The group–time interaction (P = 0.412) was not significant for total work.

Conclusion
Compared with a static VR/motor imagery control condition, I-VR during brief, high-intensity, fatigue-inducing leg cycling attenuates quadriceps pain intensity without reducing performance.
Reviews
Authors: Sander Chiara , Macadam Cynthia , Lennon Elaine , Chen Shaopeng 
Published: April 2019

How to Write for Television, 7th ed., William Smethurst (2016) London: Little, Brown Book Group, 288 pp., ISBN-10 147-2-13573-3, ebook, $6.99; ISBN-13 978-1-47213-573-5, p/bk, $18.64
Just the Funny Parts: ... and a Few Hard Truths About Sneaking into Hollywood’s Boys Club, Nell Scovell (2018) Foreword by Sheryl Sandberg, New York: Dey Street Books, 336 pp., ISBN-13 978-0-06247-348-6, h/bk, $16.44;
Screenwriting: The Sequence Approach, The Hidden Structure of Successful Screenplays, Paul Gulino (2004) New York and London: Continuum, 19 illustrations, 248 pp., ISBN-13 978-0-82641-568-4, p/bk, $26.95
Animation in Context: A Practical Guide to Theory and Making, Mark Collington (2017) London and New York: Bloomsbury, 278 pp., ISBN 978-1-47257-828-0, p/bk, £34.99; ISBN 978-1-35003-389-4, e-book, £37.78
A shoulder surfing resistance using graphical authentication system
Authors: N Rupavathy , Mary Belinda M. J Carmel , G Nivedhitha 
Published: April 2019

Authentication supported passwords is employed mostly in applications for laptop security and privacy. However, human actions like selecting unhealthy passwords and inputting passwords in an insecure approach are considered “the weakest link” within the authentication chain. Instead of impulsive alphanumerical strings, users tend to decide on passwords either short or purposeful for simple learning. With internet applications and mobile apps piling up, individuals will access these applications any time and any place with numerous devices. This evolution brings nice convenience however additionally will increase the chance of exposing passwords to shoulder surfing attacks. Attackers will observe directly or use external recording devices to gather users’ credentials. To overcome this drawback, we tend to plan a unique authentication system Pass Matrix, supported graphical passwords to resist shoulder surfing attacks. With a one-time valid login indicator and circulatory horizontal and vertical bars covering the complete scope of pass-images, Pass Matrix offers no hint for attackers to work out or slim down the password even they conduct multiple camera-based attacks. We tend to additionally enforce a Pass Matrix image on android and applied real user experiments to judge its memorability and usefulness. From the experimental result, the proposed system achieves higher resistance shoulder surfing attacks whereas maintaining usability.
Fuzzy Logic Based Interline Unified Power Quality Conditioner for Voltage Regulation of Critical Load Bus
Authors: Nithya Sree N , Srinivasa Varma P 
Published: April 2019

Interline unified power quality conditioner is the recent advancement in the world of FACTS devices and technology. The new equipment is only a mere extension of the existing FACTS device features like Distributed Static Compensator which does not limit to better voltage regulation at the gird side as well as load side bus. The effectiveness of the new FACTS device is compared with its homologous counterpart, namely conventional Unified power quality conditioner. It is observed that there is significant difference with respect to the arrangement of parallel and series connected converters. Soft computing technique namely fuzzy logic based controller for the proposed Interline unified power quality conditioner is presented in the paper. The implementation and usefulness of the proposed control topology is tested and simulated in MATLAB/SIMULINK environment.
Improvement of Solar Energy System Under Partial Shading Conditions in Koneru Lakshmaiah Education Foundation
Authors: Bhargavi B , Linga Reddy P 
Published: April 2019

This paper consists of grid connected Solar photovoltaic (SPV) system. An output of SPV depends on the irradiation and temperature. Sometimes PV module is shaded due to nearby buildings, passing clouds etc. Power extracted from such partially shaded PV array is reduced. . The PV system at KLEF deemed to be university is considered. Total Harmonic Distortion (THD) and the output powers are computed using Matlab/Simulink using LC filter .These are compared with the actual values measured from the existing system . It is found that percentage of THD is reduced.
Rotor Suspension and Stabilization of Bearingless SRM using Sliding Mode Controller
Authors: V.S.Sobhan Polamraju. , V. Nagesh Kumar G , V. Ramana Rao P 
Published: April 2019

Motors working in extreme conditions such as ultra high and low temperatures, high contamination, high purity etc. require high maintenance of mechanical bearings and the regular lubrication. Hence there is a need of a motor without mechanical bearings and lubrication in addition to simple in control and less maintenance. There by, bearingless motors (BLMs) gain more attention. The bearingless switched reluctance motor’s (BLSRM) is simple in construction and economical in addition to high speed capacity and high torque to inertia ratio. The magnetic nonlinearity arising due to double salient structure makes rotor eccentric displacement control and speed regulation complicate and needs robust control methodology such as sliding mode control (SMC) which has integrity, high certainty and rapid dynamic response when compared to typical controllers. Sliding mode can be realized with distinct classical reaching laws. This paper presents design and implementation of a SMC for a 12/14 BLSRM and the dynamic performance is endorsed by simulation using Matlab software.
Potential of Regulation of Slum Area in The Village Meranti Pandak Pekanbaru City
Authors: Putri LD , . Harsini , Nasution S R 
Published: April 2019

The slum area of Meranti Pandak is one of seven slum areas in Pekanbaru City according to Mayor's Decree No. 151/2016, is on the edge of the vulnerable Siak River with overflow due to ups and downs . This study aims to produce a draft slum area design direction as one of the references for related parties to create Pekanbaru free from slum. The research method used is quantitative research method using secondary data as well as primary data with data collection techniques through observation and filling questionnaire . Result of requirement analysis of structuring slums are the three aspects structuring approach settlement infrastructure; improvements to environmental road accessibility, drinking water services , sanitation access fulfillment,wastewater management and waste management and fire hazard security, enhanced oversight of the development of settlement development from internal parties; LKM, TIPP, POKJA and internal resource team as well as from external parties; college, consult's, government and private sectors as well as community empowerment methods; counseling, mentoring and technical assistance.
Augmentation of Mechanical Properties of Sisal Fiber Concrete
Authors: Balasubramanian M , Selvan.S Senthil , Panwar.D Vinod 
Published: April 2019

The properties of sisal fiber concrete were examined in this investigation. To find out the mechanical properties such as compressive strength, flexural strength, tensile strength was carried out for the control concretes. The similar mix proportion which was utilized to cast control concrete was used to cast sisal fiber concrete were considered and evaluated with the theoretical values as recommended by IS 456 and BS 8110 standards. For comparison, both conventional and SF concrete have been considered to study. The mix design for M20, M30 and M40 grade of concrete was finished with four distinct proportions of control concrete in trail and error method as per IS10262 – 2009. Four distinctive aspect ratios, four distinctive dosages of fiber were added to the concrete mix to find out the optimum quantity of fiber and aspect ratio. Mix batches of concrete containing 0.5%, 1%, 1.5%, 2% dosage of fiber in the aspect ratio of 100, 200, 300 and 400 were cast. This study proves that the mechanical and bond properties of both SF concrete and conventional concrete as well.
The Analysis Effect of Traffic Acces at AH. Nasution and STM Street
Authors: Lubis Marwan , Tanjung Darlina , Batu Bara Hamidun , Husni Malik Hasibuan M , Hasibuan Abdurrozzaq 
Published: April 2019

The impact of the construction of an activity center will create awakening and attraction traffic and also increase negative impact to the flow of traffic access, safety, comfortable to pedestrian, the surrounding will be influenced by building development or building activities. The analysis result has been done is know the V/R ratio of street especially at segment 4 in 2019. The ratio of the service indicators is at level E. Instability condition of the traffic access that often stop with the average speed of the vehicle about 28.5 km/h, while the volume road performence in 2024 or after the student’s building has operated about 5 years was predicted the service indicators is at level F, its mean forced flows or jammed, low speed capacity and long vehicle and became a big obstacle, while another access is at e level especially at segment 2 for A H Nasution access and segment 3 at STM street access.
Designing an Augmented Reality Strategy: ELearning/ Extensive Reading
Authors: Tunik Muharlisiani Lusy , Kurniasih Nuning , Istiqomah Lilik , Safriyani Rizka , Abid Nuskhan , Rizki Ramadhani Yulia , James Hukom Salmon , Lolo Siahaan Basar , Anas Ahmadi Edy , Hendrawati Erna 
Published: April 2019

This paper aims to see the students' responses toward the use of Augmented Reality in English learning as the application has been used in some courses in some levels of students in UWKS. The study implemented the quasi-experimental methodology by applying for the program to two groups, controlled and experimental. Survey method along with the use of questionnaire was used for data collection. The finding and discussion showed that Augmented Reality was well -utilized in the activity of English language teaching. However, the utilization needed to be more optimized and explored due to most of them were first time users.
Descry and Divulge Hitch by Using Hitch Entrapment-Bug Catcher
Authors: Vivek J , Hema B , Apoorva J 
Published: April 2019

Based on the recent survey they used to track the bugs which are stored for further uses. The system is updated with new data by the technician. To overcome this situation hitch entrapment is proposed to make testing session productive and record the details to aid the development team for quick Resolution. This work is associated with developer, tester and admin. This tool allows the developer and tester to post the queries and screenshots of their program and Admin will monitor the whole process..
Rehabilitation of Beam Column joint using Steel Fibrous Concrete
Authors: Anoop Kumar A , Ranga Rao V , Achyutha Reddy M 
Published: April 2019

An experimental study was conducted to compare the structural behavior of beam column joint before and after rehabilitation by using fibrous concrete with steel fibers as a strength enhancer material. Two specimens were examined in this study out of which one was designed according to IS 456: 2000 (control specimen) codal provision and another one was designed according to IS 13920:2016(ductile specimen). Both the supports at top and bottom faces of the column were hinged, and the load was applied on the edge of the beam. The parameter observed during the experiment was Load- deflection response for both control and rehabilitation specimens. The ultimate load carrying capacity for rehabilitated controlled specimen increased by 36.6% in comparison with controlled specimen, and the ultimate load carrying capacity for rehabilitated ductile specimen increased by 62.3% in comparison with ductile specimen. It has been observed that steel fiber reinforced concrete can enhance flexural strength, ductility and crack arrest.
An Efficient and Novel Design of Loop Filter, Charge Pump and VCO for PLL Using CMOS Technology
Authors: N.AshokKumar Dr , A.Kavitha Dr 
Published: April 2019

This article presents an occasional energy charge pump, low pass filter and voltage supervised generator for little energy section loop. PLL are generally used for synchronization and regulate of grid- associated power electronic techniques. The article enfolds the whole circuit figure of circle filter, charge pump and voltage restrict oscillator through 1.8v energy stock. This kind uses 0.18um CMOS technology. In recent times, voltage restricted oscillator are employed for phase lock loop. A great viable loop-bandwidth plan method, derivative from a distinct -time PLL model, additional complements the jitter attributes of a PLL previously somewhat evolved via optimizing precisecircuit elements. The expressed system no longer simplest guesstimates the timing jitter of a PLL, but additionally attains the most reliable bandwidth reducing the at the whole PLL jitter.
Implementation Of Wearable Radiation Detector
Authors: Josephin  Arockia Dhivya A , Chandrasekaran R , Elsa Joseph Josline , R.Thamizhvani T , K.Arun S , Manoj V 
Published: April 2019

Wearable devices are always in race to support and assist the human healthcare. The wearable devices are commonly used to monitor the physiological parameters of the humans and transmitting to the gadgets. In this paper we proposed a novel idea of monitoring the radiation in the environment and alerting the users about the radiation and level of radiation in the environment. In this paper the implementation of a radiation detector based on a semiconductor photodiode. The awareness of the hazardous radiation should be created and the people should aware of the hazardous radiation in the environment. The arduino controller proposed in the prototype acts as the heart of the wearable device. The detected radiation is transmitted through Bluetooth zixbee module and viewed in smart phones.
C3IMD : An Efficient Class-Based Clustering Classifier for Im-putation Intelligent Medical Data
Authors: Premalatha P. , Subasree S , K Sakthivel N 
Published: April 2019

The fast evolution in medical application yields to abundance of huge amount of data in volume and velocity. Due to this heterogeneous medical data generation from clinical trials, its typically not free from missing values. Previously introduced imputation techniques don’t discourse the high spatiality problems and application of distance function that even have curse on high spatiality problem. Thus, there’s a necessity an Efficient and Accurate technique to overcome this problem in Medical Data Analysis. To address the above mentioned issues, this research work proposed an efficient Class-Based Clustering Classifier for Imputation Intelligent Medical Data (C3IMD). This work was implemented in Bio Weka and studied thoroughly. To improve the classification and prediction accuracy, missing data in Medical Data Sets were filled efficiently with the help of proposed Cluster-Classifier Model. The experiments are repeated with various datasets and results are evaluated and compared with existing classifiers WPT-DELM and SVM-DELM. From the results obtained, it was revealed that the proposed Class-Based Clustering Classifier for Imputation Intelligent Medical Data (C3IMD) is outperforming both the existing models in terms of Classification Accuracy, Sensitivity, Specificity and FScore.