bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center
Authors: Keung Emily Z. , Ikoma Naruhiko , Benjamin Robert , Wang Wei‐Lien , Lazar Alexander J. , Feig Barry W. 
Published: May 2018

BackgroundThe pathogenesis of well differentiated liposarcoma (WDLPS) is poorly understood and pathologic characterization is often challenging. Descriptive terms (such as sclerosing, myxoid, inflammatory, spindle cell) are frequently encountered in the pathology reports and are of unknown clinical significance.MethodsSixty‐two patients with primary retroperitoneal WDLPS resected at our institution were identified (1996‐2011). Pathology reports of surgical resection specimens were retrospectively reviewed and descriptive qualifiers to the WDLPS diagnosis noted.ResultsDescriptive qualifiers were associated with 36 (58%) cases. WDLPS with pathologic qualifiers were more likely to be larger (median size 32 vs 25.5 cm, P = 0.01) and multifocal (36.1 vs 7.7%, P = 0.01) at diagnosis, require concomitant organ resection at surgery (50 vs 23.1%, P = 0.03), and have higher incidence of local recurrence (83.3 vs 38.5%, P < 0.01). WDLPS with pathologic qualifiers showed significantly shorter local recurrence‐free survival (LRFS) and trend towards shorter distant recurrence‐free survival and overall survival. Use of pathologic qualifiers with a WDLPS diagnosis independently predicted risk of worse LRFS.ConclusionsRetroperitoneal WDLPS tumors characterized by pathologic descriptive qualifiers appear to behave more aggressively than their more typical counterparts. Further investigation is warranted to more consistently characterize and define the pathologic features commonly seen in WDLPS as these may impact patient outcomes.
The association between preoperative serum interleukin‐6 levels and postoperative prognosis in patients with T2 gallbladder cancer
Authors: Wang Jianfa , Liu Jiazhe , Chang Qimeng , Yang Biao , Li Sen , Gu Chao 
Published: May 2018

BackgroundInterleukin‐6 (IL‐6) is closely associated with tumor progression. Whether it can predict postoperative prognosis of patients with T2 gallbladder cancer (GBC) remains controversial.MethodsWe retrospectively collected the medical records of 125 patients with T2 GBC. Then, we analyzed the association between preoperative serum IL‐6 levels and postoperative survival by multivariate Cox analyses and Kaplan‐Meier curves in exploratory subgroups.ResultsPredictive effects of serum IL‐6 levels on overall survival were similar across most of the evaluated subgroups, except in different tumor location subgroups. The independent odds ratio (OR) of serum IL‐6 levels was 2.57 (95%CI 1.73‐3.82) in the hepatic side subgroup, while it was 1.15 (95%CI 0.68‐1.93) in the peritoneal side subgroup (P = 0.014 for interaction). When we categorized serum IL‐6 levels by median value (4.2 pg/mL), the 5‐year survival rate of patients with high serum IL‐6 levels was significantly higher in the hepatic side subgroup (58.5% vs 14.8%, P < 0.001), but no such difference was found in the peritoneal side subgroup (62.2% vs 67.6%, P = 0.722).ConclusionsPreoperative serum IL‐6 is significantly associated with prognostic implications in patients with hepatic side T2 GBC, not in those with peritoneal side tumors.
Photoinduced Reversible Morphological Transformation of Azobenzene‐Containing Pseudo‐2D Polymers
Authors: Li Zili , Tang Miao , Jiang Chen , Bai Ruke , Bai Wei 
Published: May 2018

Abstract2D polymer sheets containing azobenzene are successfully prepared by a facile strategy of “2D self‐assembly polymerization (2DSP)” via free radical polymerization in solution. A bola amphiphile containing azobenzene as a novel monomer is designed and synthesized. The results indicate that single‐layer covalent pseudo‐2D polymers on a micrometer scale are obtained after polymerization with vinyl monomers. Moreover, the 2D polymer sheets are highly sensitive to UV light due to incorporation of azobenzene groups into the polymer. Upon alternative irradiation with UV and visible light, the morphological transformation between sheets and rolled‐up nanotubes can be achieved based on the reversible trans‐to‐cis photoisomerization of azobenzene units in the 2D polymer sheets.
A taxonomy and cultural analysis of intra‐hospital patient transfers
Authors: Rosenberg Alana , Campbell Britton Meredith , Feder Shelli , Minges Karl , Hodshon Beth , Chaudhry Sarwat I. , Jenq Grace Y. , Emerson Beth L. 
Published: May 2018

ABSTRACTExisting research on intra‐hospital patient transitions focuses chiefly on handoffs, or exchanges of information, between clinicians. Less is known about patient transfers within hospitals, which include but extend beyond the exchange of information. Using participant observations and interviews at a 1,541‐bed, academic, tertiary medical center, we explored the ways in which staff define and understand patient transfers between units. We conducted observations of staff (n = 16) working in four hospital departments and interviewed staff (n = 29) involved in transfers to general medicine floors from either the Emergency Department or the Medical Intensive Care Unit between February and September 2015. The collected data allowed us to understand transfers in the context of several hospital cultural microsystems. Decisions were made through the lens of the specific unit identity to which staff felt they belonged; staff actively strategized to manage workload; and empty beds were treated as a scarce commodity. Staff concepts informed the development of a taxonomy of intra‐hospital transfers that includes five categories of activity: disposition, or determining the right floor and bed for the patient; notification to sending and receiving staff of patient assignment, departure and arrival; preparation to send and receive the patient; communication between sending and receiving units; and coordination to ensure that transfer components occur in a timely and seamless manner. This taxonomy widens the study of intra‐hospital patient transfers from a communication activity to a complex cultural phenomenon with several categories of activity and views them as part of multidimensional hospital culture, as constructed and understood by staff.
A multifaceted approach towards interpreting early life experience and infant feeding practices in the ancient Atacama Desert, Northern Chile
Authors: King C. L. , Snoddy A. M. , Millard A. R. , Gröcke D. R. , Standen V. G. , Arriaza B. T. , Halcrow S. E. 
Published: May 2018

AbstractInterpreting early life experience in the past is of considerable interest to archaeologists, yet remains fraught with difficulty. Children are sensitive barometers of population health in general. In addition, infant feeding practices, and stresses experienced during infancy and childhood, have important effects on adult health and demographic changes. Understanding how diet and physiological stress interact is therefore of significance, but most bony indicators of stress have non‐specific etiologies that cannot be tied to events during childhood. The recent advent of incremental isotopic techniques means we now have the potential to identify periods of stress and dietary change during childhood through changes to stable carbon and nitrogen isotopic ratios during tissue formation. Being able to establish these individual weaning trajectories allows us to consider individuality in past weaning choices, giving the bioarchaeologist a more nuanced picture of the past. Here, we investigate whether combining paleopathological and isotopic data can give insight into the synergy between infant feeding and stress. We present a case study of a 5‐year‐old child from an early agricultural period archaeological site in the northern Atacama Desert, Chile. We show that, despite physiological stress likely affecting isotopic ratios in this individual, a weaning curve is visible and the interpretation of weaning behaviour is possible. In addition, we suggest that there is isotopic evidence for a micronutrient deficient weaning diet that may be correlated with bony evidence for pathology.
An ST2‐dependent role of bone marrow‐derived group 2 innate lymphoid cells in pulmonary fibrosis
Authors: Zhao Yuyue , De Los Santos Francina Gonzalez , Wu Zhe , Liu Tianju , Phan Sem H 
Published: May 2018

AbstractRecent evidence supports that bone marrow (BM)‐derived hematopoietic progenitor cells play an important role in lung injury and fibrosis. While these cells give rise to multiple cell types, the ST2 (Il1rl1)‐expressing group 2 innate lymphoid cells (ILC2s) derived from BM progenitors have been implicated in tissue repair and remodeling, including in lung fibrosis. To further investigate the precise role of BM‐derived ILC2s in the pathogenesis of fibrotic lung disease, their importance in the bleomycin‐induced lung fibrosis model was evaluated by analyzing the effects of selective ST2 deficiency in the BM compartment. The results showed that while ST2‐sufficient control mice exhibited activation of lung IL‐33/ST2 signaling, ILC2 recruitment, IL‐13 induction, and fibrosis, these responses were significantly diminished in ST2‐deficient‐BM chimera mice, with selective loss of ST2 expression only in the BM. This diminished response to bleomycin was similar to that seen in ST2 global knockout mice, suggesting the predominant importance of ST2 from the BM compartment. In wild‐type mice, ILC2 recruitment to the lung was accompanied by a concomitant decrease in ST2+ BM cells. ST2‐deficient BM cells were unresponsive to IL‐33‐induced ILC2 maturation. Finally, lineage‐negative wild‐type, but not ST2‐deficient BM cells from bleomycin‐treated mice stimulated lung fibroblast type I collagen expression, which was associated with elevated TGFβ expression in the BM cells. Taken together, these findings suggested that the BM‐derived ILC2s were recruited to fibrotic lung through the IL‐33/ST2 pathway, and contributed to fibroblast activation to promote lung fibrosis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Randomized web‐based physical activity intervention in adolescent survivors of childhood cancer
Authors: Howell Carrie R. , Krull Kevin R. , Partin Robyn E. , Kadan‐Lottick Nina S. , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. 
Published: May 2018

AbstractBackgroundHealthy lifestyle choices, including participation in regular physical activity, may improve health outcomes in survivors of childhood cancer. We aimed to evaluate the efficacy of a web‐delivered physical activity intervention among adolescent survivors to increase moderate to vigorous physical activity (MVPA) and improve fitness and neurocognitive and health‐related quality of life (HRQoL) over 24 weeks.ProcedureThis randomized controlled trial was conducted among survivors (aged ≥11 to <15 years) treated at a single institution. Participants were randomized to either a physical activity intervention delivered over the internet or a control group. The intervention group received educational materials, an activity monitor, and access to an interactive website designed to motivate increased physical activity via rewards; the control group received an activity monitor and educational materials. Physical activity, fitness, and neurocognitive and HRQoL outcomes were assessed at baseline and at 24 weeks. Mean changes were compared between groups using paired t‐tests.ResultsOf the 97 survivors enrolled, 78 completed the study; the mean age was 12.7 (standard deviation 1.1), 80% were White, and 55.1% were female. Fifty‐three survivors were assigned to the intervention and 25 to the control group. While survivors in the intervention group increased, and those in the control group decreased (4.7 ± 119.9 vs. –24.3 ± 89.7 min) weekly MVPA, this difference was not significant (P = 0.30). However, hand grip strength, number of sit‐ups and pushups, neurocognitive function, and HRQoL outcomes improved in the intervention, but not in the control group.ConclusionsAn interactive, rewards‐based intervention designed to increase MVPA is feasible in adolescent survivors of childhood cancer.
Successful reduced‐intensity conditioning hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia in two children
Authors: Andolina Jeffrey R. , Reinish Ariel L. , Akhtar Razia , Noronha Suzie , Shand Jessica C. , Girvin Angela , Korones David N. , Bruckner Lauren B. , Mullen Craig A. , Curran Kevin J. , Boulad Farid 
Published: May 2018

AbstractParoxysmal nocturnal hemoglobinuria (PNH) is an extremely rare cause of bone marrow failure in children. We report two children who presented with pancytopenia, and were diagnosed with PNH with severe aplastic anemia. Both children underwent upfront, successful hematopoietic stem cell transplantation with reduced‐intensity conditioning. One patient had a syngeneic donor, and one patient had a 10/10 matched unrelated donor. Neither patient developed graft versus host disease, infections, or recurrent PNH. Reduced‐intensity conditioning hematopoietic stem cell transplantation is a reasonable therapy for PNH with marrow failure in children.
In situ Synthesized Energetic Salts Based on the C−N Fused Tricyclic 3,9‐Diamine‐6,7‐Dihydro‐Bis(triazolo)‐Tetrazepine Cation: A Family of High‐Performance Energetic Materials
Authors: Xu Yuangang , Zhu Zhongqin , Shen Cheng , Lin Qiuhan , Lu Ming 
Published: May 2018

AbstractA new family of 3,9‐diamino‐6,7‐dihydro‐5H‐bis([1,2,4]triazolo)[4,3‐e : 3′,4′‐g][1,2,4,5]tetrazepine‐2,10‐diium salts was explored as fused tricyclic triazole based energetic materials. These salts and their fused cations were constructed by in situ synthesis with 4,4′,5,5′‐tetraamino‐3,3′‐bi‐1,2,4‐triazole as the raw material. All of the new compounds were fully characterized by elemental analysis, IR spectroscopy, 1H, 13C, and (in some cases) 15N NMR spectroscopy, and thermal analysis. The structures of five salts were confirmed by single‐crystal X‐ray analysis. Computational studies associated with heats of formation and detonation properties were performed by using Gaussian 09 and EXPLO5 v6.01 programs, respectively. The desired fused tricyclic energetic salts (especially for 4 and 5, d: 1.85‐1.92 g cm−3; D: 8622–8942 m s−1; P: 34.61‐37.38 GPa) display interesting thermal behaviour and are predicted to be high‐performance energetic materials.
Functional and evolutionary analysis of viral proteins containing a Rossmann‐like fold
Authors: Medvedev Kirill E. , Kinch Lisa N. , Grishin Nick V. 
Published: May 2018

AbstractViruses are the most abundant life form and infect practically all organisms. Consequently, these obligate parasites are a major cause of human suffering and economic loss. Rossmann‐like fold is the most populated fold among α/β‐folds in the Protein Data Bank and proteins containing Rossmann‐like fold constitute 22% of all known proteins 3D structures. Thus, analysis of viral proteins containing Rossmann‐like domains could provide an understanding of viral biology and evolution as well as could propose possible targets for antiviral therapy. We provide functional and evolutionary analysis of viral proteins containing a Rossmann‐like fold found in the evolutionary classification of protein domains (ECOD) database developed in our lab. We identified 81 protein families of bacterial, archeal, and eukaryotic viruses in light of their evolution‐based ECOD classification and Pfam taxonomy. We defined their functional significance using enzymatic EC number assignments as well as domain‐level family annotations.
Structure and properties of AB21, a novel Agaricus bisporus protein with structural relation to bacterial pore‐forming toxins
Authors: Komárek Jan , Ivanov Kavková Eva , Houser Josef , Horáčková Aneta , Ždánská Jitka , Demo Gabriel , Wimmerová Michaela 
Published: May 2018

AbstractWe report the characterization of the dimeric protein AB21 from Agaricus bisporus, one of the most commonly and widely consumed mushrooms in the world. The protein shares no significant sequence similarity with any protein of known function, and it is the first characterized member of its protein family. The coding sequence of the ab21 gene was determined and the protein was expressed in E. coli in a recombinant form. We demonstrated a high thermal and pH stability of AB21 and proved the weak affinity of the protein to divalent ions of some transition metals (nickel, zinc, cadmium, and cobalt). The reported crystallographic structure exhibits an interesting rod‐like helical bundle fold with structural similarity to bacterial toxins of the ClyA superfamily. By immunostaining, we demonstrated an abundance of AB21 in the fruiting bodies of A. bisporus.
Synthesis and Structural Diversity of Main Group Metal Coordination Complexes Constructed from V‐Shape Bis(3‐methyl‐1H‐pyrazole‐4‐carboxylic acid)alkane Ligands
Authors: Cheng Meiling , Bao Jinting , Wu Yujuan , Yang Bingxin , Wang Qinghua , Sun Lin , Liu Qi 
Published: May 2018

AbstractReaction of H2L1/H2L2/H2L3 with corresponding main group metal salts generated five complexes, [Mg(L1)(phen)(H2O)3]⋅5H2O (1, mononuclear), [Sr(CH3OH)(L1)2Sr(H2O)2]2n⋅nH2O (2, 2D), [Ba(L2)(H2O)3]n (3, 2D), [Pb(L2)(2,2′‐bpy)]2n⋅9nH2O (4, 1D) and [Pb(L3)(phen)]2⋅2DMF (5, dinuclear) (H2L1=1,1'‐methylenebis(5‐methyl‐pyrazole‐4‐carboxylic acid, H2L2 = 2'‐methylenebis(3‐methyl‐pyrazole‐4‐carboxylic acid, H2L3=1,1'‐methylenebis(3‐methyl‐pyrazole‐4‐carboxylic acid; 2,2’‐bpy=2,2′‐bpyridine and phen=1,10‐phenanthroline). In the zwitterionic complex 1, a loop‐loop water‐water hydrogen bonded chain presented in the 3D supramolecular network, which was constructed by π⋅⋅⋅π interactions and hydrogen bonds. In CPs 2 and 3, the 1D inorganic M–O–M connectivity was built from Sr2O16 and BaO9 polyhedra, respectively. The similar 24‐membered Pb2(L2)2/Pb2(L3)2 macrocycle occurred in both 1D polymer 4 and dinuclear complex 5, with two 2,2’‐bpy molecules located inside or two phen molecules outside each macrocycle respectively. The thermal and photoluminescent properties of 1–5 in the solid state have also been investigated.
A Relativistic DFT Probe of Thorium and Protactinium Complexes Supported by Heterocalix[4]arene and Redox Properties of Early‐Middle Actinides
Authors: Bi Yan‐Ting , Bao Zhe , Li Li , Shen Zhong‐Hui , Pan Qing‐Jiang 
Published: May 2018

AbstractThorium and protactinium complexes of trans‐calix[2]benzene[2]pyrrolide (H2L) have been examined using a relativistic density functional theory, where the metal center has +IV and +III oxidation states and is saturated by a borohydride donor. Good agreement in geometry parameters has been achieved for the thorium(VI) complex compared with its experimentally obtained analogue. Three types of conformers, labeled as (ArL)(Anm)(2HB), (ArL)(Anm)(3HB) and (PlL)(Anm)(3HB) (An=Th and Pa, m=VI and III), are energetically favored for each complex. The first and last configurations are found to be the most stable for tri‐ and tetravalent complexes, respectively. Intriguing δ(An−Ar) bonding(s) are revealed for trivalent complexes (ArL)(AnIII)(2HB); and (PlL)(PaIV)(3HB) has a Pa(5f)‐dominated HOMO, while (PlL)(ThIV)(3HB) displays a 5f06d07s0 electronic configuration. Exothermic process was calculated for reactions starting from actinide borohydride sources and various macrocyclic ligands. From a thermodynamic perspective, this provides synthetically accessible possibility of these complexes. The mechanism of reducing tetra‐ to trivalent actinide complexes has been proposed. Reduction potentials were calculated to follow the order of Th < Pa < U < Np < Pu, which well reproduces reported results of aquo AnVI/AnIII ions.
Integrating carbon dioxide removal into EU climate policy: Prospects for a paradigm shift
Authors: Geden Oliver , Scott Vivian , Palmer James 
Published: May 2018

Scenarios meeting the Paris Agreement's temperature targets envisage a major and imminent deployment of technologies to remove carbon dioxide from the atmosphere, of which there has been almost no practical implementation to date. Here we explore the political dimensions and policy implications of expectations for “negative emissions” in the European Union (EU), considering its largely successful leadership role in mitigation action and corresponding low‐carbon technology development and deployment. Carbon dioxide removal and especially Bio‐Energy with Carbon Capture and Storage present significant challenges to the EU's dominant climate policy paradigm and low‐carbon policy experience. Considering this challenge, we assess expectations for widespread implementation of carbon dioxide removal in the EU to be unrealistic, and explore possible pathways for its more limited introduction.This article is categorized under:
Policy and Governance > Multilevel and Transnational Climate Change Governance
The Carbon Economy and Climate Mitigation > Policies, Instruments, Lifestyles, Behavior
Yangian symmetry for bi-scalar loop amplitudes
Authors: Chicherin Dmitry , Kazakov Vladimir , Loebbert Florian , Müller Dennis , Zhong De-liang 
Published: May 2018

AbstractWe establish an all-loop conformal Yangian symmetry for the full set of planar amplitudes in the recently proposed integrable bi-scalar field theory in four dimensions. This chiral theory is a particular double scaling limit ofγ-twisted weakly coupled$$ \mathcal{N}=4 $$N=4SYM theory. Each amplitude with a certain order of scalar particles is given by a single fishnet Feynman graph of disc topology cut out of a regular square lattice. The Yangian can be realized by the action of a product of Lax operators with a specific sequence of inhomogeneity parameters on the boundary of the disc. Based on this observation, the Yangian generators of level one for generic bi-scalar amplitudes are explicitly constructed. Finally, we comment on the relation to the dual conformal symmetry of these scattering amplitudes.
Recurrent Penile Fracture—Case Report and Alternative Surgical Approach
Authors: Nascimento Bruno , Guglielmetti Giuliano B. , Miranda Eduardo P. , Ivanovic Renato F. , Batagello Carlos A. , Nahas William C. , Srougi Miguel , Cury José 
Published: May 2018

Abstract

Introduction
Penile refracture is an exceedingly rare event, with very few published studies. To the best of our knowledge, this is the first documented case in the literature of penile fracture with 3 same-site recurrences.

Aims
To describe the case of a 25-year-old Caucasian man with recurrent penile fracture ultimately treated with resuture and patch reinforcement.

Methods
Patient history (clinical and surgical) and literature review.

Results
After the 3rd same-site recurrence, patch reinforcement over the sutured area was performed. The patient had an uneventful recovery and no recurrences to date.

Conclusion
There is no evidence indicating the superiority of non-absorbable sutures. Bovine pericardium reinforcement over the sutured area was used to minimize the chance of another recurrence. More studies are necessary to investigate its safety and efficacy in this scenario.