bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary measurement of circulating tumor DNA for treatment monitoring and prognosis of metastatic colorectal cancer patients
Authors: Song Tao , Mao Fei , Shi Li , Xu Xuemei , Wu Zirong , Zhou Juan , Xiao Meifang 
Published: July 2018

Abstract

Background
Solid tumor tissue testing is the gold standard for molecular-based assays for metastatic colorectal cancer (mCRC). This poses challenges during treatment monitoring. Total DNA derived from urine specimens offers clear advantages to track the disease dynamics. Our study aims to evaluate the sensitivity for total DNA recovered from urine and its clinical relevance to mCRC.

Methods

KRAS mutations in urine specimens were examined in 150 mCRC patients. Baseline concordance was established to determined clinical relevance. The total DNA quantities were also prospectively examined in serial samplings during treatment.

Results
Analysis of the genetic mutations showed good agreement for baseline samples. Matched tumor and urine specimens’ molecular profiles were observed to have 90% concordance. Comparing with healthy volunteers, we established a cutoff of 8.15 ng that demonstrated elevated total DNA levels was associated with mCRC patients (sensitivity: 90.7%; specificity: 82.0%). For patients treated with chemotherapy or anti-epidermal growth factor receptor inhibitors, DNA quantity mirrored early treatment response. Survival analysis showed that patients with sustained elevated quantities of KRAS mutations had poorer outcome.

Conclusions
Total urine DNA offers a viable complement for mutation profiling in mCRC patients, given the good agreement with matched tumor samples. Our study also established that this is specific based on the results from healthy individuals. Serial monitoring of total DNA levels allowed early prediction to treatment response and was effective to identify high risk patients. This is potentially useful to complement current disease management.
Inner Life, Meaningful Work, Conditions for Community, and Organisational Citizenship Behaviour
Authors: Azeez Rasheed Olawale , Genty Kabiru Ishola 
Published: July 2018

Abstract
This paper investigated the relationship that exists among inner life, meaningful work, conditions for community, and organisational citizenship behaviour amongst Nigerian academics. The study embraced a quantitative approach using survey research design, which is ex post facto in nature with the engagement of quantitative and correlational methods. Thus, a convenience sampling technique was utilised to administer 328 questionnaires amongst the academics of two Nigerian public universities. Three hypotheses were stated and tested using inferential statistics tools via the IBM Statistical Package for the Social Sciences (SPSS) version 20 and the Analysis of Moment Structure (AMOS) version 22. The multivariate statistical processes used in this paper are confirmatory factor analyses, structural equation modelling, as well as model fit indices. The results indicated an insignificant positive relationship between inner life and organisational citizenship behaviour. However, it was evident that a strong positive relationship existed between conditions for community and organisational citizenship behaviour. In contrast, the study revealed that there was no significant relationship between meaningful work and organisational citizenship behaviour. Therefore, this paper concludes that the management of universities should always communicate the mutual benefit of engaging in organisational citizenship behaviour to the members of their staff through effective conditions for community, such as aiding of staff personal growth and fair evaluation of work.
Determination of Sorption Properties of Heavy Metals in Various Biosorbents
Authors: Kłos Andrzej 
Published: July 2018

Abstract
Various techniques of determination of properties of physicochemical processes of heavy metal sorption in biosorbents were analysed. The methods of preparing and storing samples, conditions of experiment performance, as well as the methods of data interpretation were discussed. Two procedures of study were analysed: (1) in the static system of biosorbent-solution contact and (2) in the system of dynamic flow of solution. Copper cation sorption was studied. The effect of consecutive stages of the study on the quality of final results was shown. A high degree of uncertainty of the sorption capacity assessment was reported, which was dependent on the manner of conducting the study. The application of the pseudo-second order reaction model was substantiated to describe kinetics of cation-exchange sorption and the model of Langmuir isotherm to describe equilibria. The study conducted reveals that in order to perform comparative analyses, it is necessary to establish a joint concept of conducting studies and the interpretation of results.
On Arbitral Jurisdiction. How to Deal with the Complementarity between Arbitral Tribunals and the Courts?
Authors: Cavallini Cesare 
Published: July 2018

Abstract
Why might one argue that the arbitral tribunal should have the “competence” to rule, as of right, upon its own jurisdiction? Is this natural power consistent with the legitimacy of arbitration? Can it unquestionably achieve the greatest level of efficiency for the parties?
Although a considerable body of literature has attempted to answer these questions, this article aims to address (and partially reframe) the core issues relating to arbitral jurisdiction by comparing different legal systems and operative solutions in order to search for new and valuable insights on the topic . There is no doubt, in fact, that the orthodox position traditionally starts from the assumption that access to the courts within parallel proceedings, which (also) questions the allocation of jurisdiction, is problematic also due to the risk of delaying tactics by one party. According to this line of reasoning, when the authority of the arbitrators is challenged, the balance between the legitimacy and the efficiency of the arbitration process could be conditioned by prejudices relating to the (necessary) interference of the courts with the power of the arbitral tribunal to determine its own potestas judicandi (or its lack thereof) on the merits.
In an attempt to move on from the classical framing of this issue and towards a comparative evaluation of the rationales and values underlying domestic legislation on arbitral jurisdiction, considered also with reference to the provisions of the UNCITRAL Model Law, this article will seek to provide a solution that is rooted in the complementary role of the courts and of arbitral tribunals. The complementarity between arbitral tribunals and the courts will be shown to be key in securing the legitimacy of arbitration and the actual pre-eminence of this source of alternative private justice and, accordingly, also as a way of striking the optimum balance with the efficiency of the arbitration process.
On the Influence of Walking on Hazard Detection for Prospective User-Centered Design of an Assistance System for Older Pedestrians
Authors: Protzak Janna , Wiczorek Rebecca 
Published: July 2018

Abstract
As older pedestrians are at high risk of being involved in car crashes, an assistance system is currently under development. One of it’s aims is to encourage them to stop walking before looking for traffic. The approach was evaluated in two studies. Age group -young vs. old- and motoric condition -walking vs. standing- served as independent variables in both experiments. Experiment one was conducted in a pedestrian traffic simulation with a traffic related visual hazard detection task with simulated walking. Analysis revealed no age-specific dual-task costs for accuracy and response time. This unexpected result was ascribed to the insufficient operationalization of the walking task, which lacked important aspects of real walking such as requirements of keeping the balance. Therefore, experiment two, comprised real walking but a simple visual task. In the second experiment older participants missed more targets than younger. More important, number of errors increased as a function of motor load only for older participants. Response times were enhanced for older participants and faster for both groups while standing compared to walking. Results are discussed with regard to the development of an assistance systems for older pedestrians and theoretical implications for prospective user-centered experimental design.
Use of Information and Communication Technology in Healthcare Context by Older Adults in Germany: Initial Results of the Tech4Age Long-Term Study
Authors: Mertens Alexander , Rasche Peter , Theis Sabine , Bröhl Christina , Wille Matthias 
Published: July 2018

Abstract
In 2016 the interdisciplinary research team Tech4Age started its long-term survey to evaluate the use of information and communication technology (ICT) by older adults (60+) in Germany. This study focuses on the use of ICT devices and applications, the evaluation how these devices are operated in terms of ergonomic hand positions, the investigation of health information usage as well as technology affinity, health literacy and computer literacy. The first run of the Tech4Age long-term study was done by sending a paper-based questionnaire to 5,000 individuals older than 60 years randomly selected from the total German population and equally locally distributed within Germany. Responses were collected from N = 551 participants with a mean age of 69.17 years (SD = 5.787). The gender ratio of the sample is balanced, including 51.3% male and 48.7% female. Results provide descriptive insights into technology usage and knowledge about influencing factors. Older adults already use modern ICT on a large scale, for example to do online banking or for mobility reasons (navigation, booking tickets, etc.), but health-related ICT products and applications have been used less, mainly due to mistrust. Investigation of health information usage showed that doctors and pharmacists are the main sources older adults rely on. Two thirds of all participants were satisfied with general information they got about health. The evaluation of the ergonomic use of ICT devices revealed a common way of use, namely that a majority of older adults prefer to use their ICT devices in the case of a small display in portrait mode and in the case of larger displays in portrait as well as landscape mode. Touch input is always performed with a finger or the second hand, the one not holding the device. The article will present and discuss the results in detail.
Human-Machine Integration as Support Relation: Individual and Task-Related Hybrid Systems in Industrial Production
Authors: Weidner Robert , Argubi-Wollesen Andreas , Karafillidis Athanasios , Otten Bernward 
Published: July 2018

Abstract
One of the greatest societal challenges right now can be seen in the design of the interaction between human and technology. Especially in recent years this has become more intense. In almost all life situations, we are already supported or assisted by technology. Such systems come in various forms and characteristics. This paper will report on an ongoing research project named smartASSIST which aims to establish methods for the development of wearable systems for physical support as well as exemplary supporting technologies. The research is based upon a theoretical foundation of human-machine support relations which leads to the conceptual approach of constructing Human-Hybrid-Robot (HHR) systems.
Biodiesel production using immobilized lipase supported on a zirconium-pillared clay. Effect of the immobilization method
Authors: Colín-Luna J.A. , Zamora-Rodea E.G. , González-Brambila M.M. , Barrera-Calva E. , Rosas-Cedillo R. , Medina-Mendoza A.K. , García-Martínez J.C. 
Published: July 2018

AbstractEdible oils, used in restaurants and households, have become a potential source of environmental pollution because their residuals are indiscriminately poured into rivers and lakes. One cost-effective and sustainable way to treat this waste is using this biomass in the production of biofuels, such as biodiesel. The main reactions for obtaining biodiesel are catalyzed in a homogeneous phase, using basic or acid solutions (NaOH or H2SO4, respectively) or in a heterogeneous phase, using a porous material with or without metals. One interesting reaction, owing to its low energy consumption, is carried out using biocatalysts of enzymes immobilized in porous materials. In this work, a porcine pancreatic lipase (PPL) was immobilized in a zirconium-pillared clay (Zr-PILC) by means of two syntheses: adsorption (PPL/Zr-PILC ADS) and cross-linking (PPL/Zr-PILC CL). The biocatalysts were used in the transesterification of canola oil. The amount of methyl esters was produced in the order Zr-PILC ≈ PPL ≪ PPL/Zr-PILC CL ≪ PPL/Zr-PILC ADS. According to these results, the activity and selectivity are a function of the method of synthesis and show the potential of these biocatalysts to transform waste oil in biodiesel at low cost by means of a sustainable process.
To diet or not to diet in neonatal diabetes responding to sulfonylurea treatment
Authors: Ioacara Sorin , Sava Elisabeta , Barosan Alexandra , Cojocaru Florentina , Gutan Adelina , Fica Simona 
Published: July 2018

Abstract

Background
Neonatal diabetes mellitus (NDM) is defined as a monogenic form of diabetes that occurs in the first 6 months of life. As information on diet in NDM patients successfully treated with sulfonylurea is not yet available, we aimed to investigate the hypothesis that a carb-restricted diet is not needed in such cases.

Case presentation
In this case report, we present a successful implementation of a completely liberalized diet in a young patient with NDM, developmental delay and epilepsy (DEND syndrome), who was also switched to sulfonylurea treatment. The excellent metabolic control during follow-up despite completely ignoring any diet suggests that at least in some patients this approach might work.

Conclusions
If our proposed hypothesis is also confirmed by other reports, it might add significantly to the quality of life of these patients and broaden the knowledge in this medical field.
Crystal structure of 1-(5-bromo-2-(4-methoxyphenyl)-1H-indol-7-yl)ethanone oxime, C17H15BrN2O2
Authors: Mphahlele Malose J. 
Published: July 2018

Abstract
C17H15BrN2O2, monoclinic, P21/c, a = 14.4197(9) Å, b = 7.5423(5) Å, c = 14.9602(9) Å, β = 114.665(2)°, V = 1478.59(16) Å3, Z = 4, R
gt(F) = 0.0196, wR
ref(F
2) = 0.0526, T = 173(2) K.
Clustered plasticity in Long-Term Potentiation: How strong synapses persist to maintain long-term memory
Authors: Mikhaylova Marina , Kreutz Michael R. 
Published: July 2018

Abstract
The storage of memory requires at least in part maintenance of long-term potentiation (LTP) in dendritic spine synapses. Neighboring synapses are frequently arranged into functional clusters. At present, it is still unclear how these clusters evolve, why they are stable for longer time periods and how spines interact within a cluster. In this review, we will provide an overview of current concepts of clustered plasticity and we will discuss cellular as well as molecular mechanisms that might be relevant for spine stability and associated functions in the context of LTP. We will propose that dynamics of initially formed clusters depend on compartmentalization of dendrites and that activity-dependent gene expression kicks in to preserve differences in synaptic weight. We will discuss how mechanisms of synaptic tagging, the presence of secretory organelles in dendrites and the incorporation of synaptic scaling factors that are encoded by immediate early genes interact to preserve clustered plasticity.
NSSC pulping of fast growing trees
Authors: Vidaurre Graziela Baptista , Pereira Miguel , Boschetti Walter Torezani Neto , Patt Rudolf , Colodette Jorge Luiz , Vital Benedito Rocha , de Almeida Maria Naruna Felix 
Published: July 2018

Abstract
Neutral sulphite semichemical pulping (NSSC) of Schizolobium amazonicum (Paricá), a fast-growing Amazonian tree, was compared with that of Eucalyptus grandis (eucalypt), one of the most important wood sources for the Brazilian pulp industry, and with mixtures of both woods in different proportions (mix). Wood chips prepared from 7-year old trees were steamed, cooked using the NSSC process and defibered in a 12” disc refiner in three stages. The paricá wood produced pulp of lower yield (75 %) than eucalypt (77 %) at 16 % sulfite/150 min/170 °C. The paricá and eucalypt pulps were bleached to about 68 and 74 % ISO brightness, respectively, by the QPFAS sequence. Paricá consumed more energy for refining in comparison with the eucalypt wood. The wood mix produced lower yield and brightness than the single species processed separately.
The Intermediate World: A Key Concept in Beautiful Thinking
Authors: Jørgensen Dorthe 
Published: July 2018

Abstract
The term ‘the intermediate world’ is a key concept in Den skønne tænkning (Beautiful Thinking) and the metaphysics of experience presented by this book. The metaphysics of experience is about the experiences of transcendence and beautiful thinking that take place in the intermediate world. In the article “The Intermediate World,” this subject is introduced through a discussion of thoughts and concepts formulated by Paul Klee (Zwischenwelt), Alexander Gottlieb Baumgarten (beautiful thinking), Aristotle (phantasia), Immanuel Kant (expanded thinking), Mark C. Taylor (imagination), and Eugenio Trías (the limit). The text depicts the intermediate world as the level of experience at which the understanding does not yet distinguish between subject and object. The intermediate world is thus not a realm between human and world, nor is it something outside the world we know. The intermediate world is rather the present world in its most original state: the ‘place’ where we find the source of all experience and cognition, a source called ‘basic experience’ characterized by sensation, faith, and comprehension. In this realm, imagination is active and takes the form of an objective force rather than a subjective mental power. Imagination opens mind and world, thus allowing not-yetactualized possibilities to become perceivable.
Environment aware ADL recognition system based on decision tree and activity frame
Authors: Melo Nicholas , Lee Jaeryoung 
Published: July 2018

Abstract
The interest towards robots for elderly care has been growing in the last years. Systems aiming to integrate robot interactive components and the user’s activity recognition system are increasing as well. This work presents an activity aware intelligent system that supports user in his/her daily life tasks. The proposed system aims to integrate three important aspects into a smart house application (environment monitoring, user activity recognition and user friendly interaction). The information gathered from sensors across the environment is structured as the state of the environment in a compacted form called activity frame. This specific frame is used by a predictor (based on the decision tree method), in order to recognize the activities that have been performed by the user inside his/her domestic environment. The recognized activity is used by an user-interactive component, which uses the predicted behavior as a guideline for its interaction planner. The presented activity recognition system was tested with the data provided by different smart home projects, and the recognition rate for the proposed predictor has high recognition rate compared to other similar ones. The architecture described by the sensory network allows the system to be easily implemented in real time in a smart house context.
Investigation of the Biocompatibility of Surgical Masks
Authors: Sipahl Hande , Bayram Filiz Esra Onen , Palabiyik Saziye Sezin , Bayram Dilara , Aydin Ahmet 
Published: July 2018

Abstract
According to the ISO10993-1 standard medical devices should be evaluated before marketing. Although there are studies that monitor the toxicity of several marketed medical devices, none of them describe the toxicity of masks that are widely used to avoid occupational exposure to biological hazard or toxic chemicals. The aim of this study was to evaluate the biocompatibility of eight purchased surgical masks of different brands, investigating their cytotoxicity and inflammation inducing capacity. Cytotoxicity was assessed via the MTT cell viability assay and inflammation was monitored by measuring nitrite, kynurenine and tryptophan levels. A preliminary study revealed that four samples were capable of killing L929 cells. Therefore the materials composing these masks were also evaluated separately. While the exposure to non-woven materials did not involve any changes in cell survival, exposing cells to elastic and sponge materials led to death in significant levels. Also, significant increases in nitrite levels with a decrease in tryptophan and kynurenine levels were obtained with cells treated with these materials, suggesting an inflammatory response that could be related to the observed cytotoxicity. Our studies revealed that the half of the randomly collected masks did not suit the biocompatibility criteria established by the ISO10993-1 standard, which is a quite unexpected result.
Acute Effects of Battle Rope Exercise on Performance, Blood Lactate Levels, Perceived Exertion, and Muscle Soreness in Collegiate Basketball Players
Authors: Chen Wei-Han , Yang Wen-Wen , Lee Yi-Hua , Wu Huey-June , Huang Chen-Fu , Liu Chiang 
Published: July 2018

Abstract
Chen, WH, Yang, WW, Lee, YH, Wu, HJ, Huang, CF, and Liu, C. Acute effects of battle rope exercise on performance, blood lactate levels, perceived exertion, and muscle soreness in collegiate basketball players. J Strength Cond Res 34(10): 2857–2866, 2020—This study investigated the acute effects of battle rope (BR) exercise on basketball players' performance, blood lactate levels, rating of perceived exertion (RPE), and perceived muscle soreness. Fifteen well-trained Division-I male basketball players underwent the same test procedure at baseline, before BR exercise (30 minutes of rest after the baseline test), and after BR exercise. The 30-minute experimental protocol comprised 6 BR exercises at a work-to-rest ratio of 1:2 (20-second exercise and 40-second rest). Shooting accuracy, basketball chest pass speed, countermovement jump (CMJ) height, blood lactate levels, RPE (Borg Category-Ratio-10 scale), and perceived muscle soreness (visual analog scale, 0–100 mm) were measured in each test. The results indicated no change for any variables between baseline and before BR exercise. After BR exercise, performance decrements (p < 0.05) were recorded in shooting accuracy (16.9%) and basketball chest pass speed (9.1%), but no significant changes were observed for CMJ height. Battle rope exercise caused increases in blood lactate levels (13.6 mmol·L−1), RPE (9.9), and perceived muscle soreness (upper-limb: 63–67 mm; trunk: 43–68 mm; and lower-limb: 45–52 mm). In conclusion, BR exercise is physically demanding on the upper body, resulting in decreased performance in shooting accuracy and basketball chest pass speed. Battle rope exercise may not be beneficial before a practice or game because it triggers acute exercise-induced performance decrements and fatigue. However, BR exercise may be suitable for basketball training sessions in which the objective is to strengthen technical skills under fatiguing conditions.