bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA
Authors: Kang Min , Ren Meiping , Li Yan , Fu Yuqiong , Deng Minmin , Li Changping 
Published: July 2018

Abstract
Background
Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell carcinoma (ESCC). While cell behavior can be modulated by long non-coding RNAs (lncRNAs), the roles of lncRNAs within extracellular vesicles (exosomes) are largely unknown. Therefore, we investigated the involvement and regulatory functions of potential lncRNAs enclosed in exosomes during formation of chemoresistance in human ESCC.

Methods
Gefitinib-resistant cell lines were established by continuously grafting TE1 and KYSE-450 cells into gefitinib-containing culture medium. LncRNA microarray assay followed by RT-qPCR were used to verify the differential expression of lncRNA Prostate Androgen-Regulated Transcript 1 (PART1) between gefitinib resistant and parental cell lines. RNA fluorescence in situ hybridization (FISH) was used to investigate whether extracellular PART1 could be incorporated into exosomes and transmitted to recipient cells. Subsequently, a series of in vitro assays and a xenograft tumor model were used to observe the functions of lncRNA PART1 in ESCC cells. A signal transduction reporter array, bioinformatics analysis, western blotting, and immunofluorescence were carried out to verify the regulation of PART1 and its downstream Bcl-2 signaling pathway.

Results
lncRNA PART1 was upregulated in gefitinib-resistant cells when compared to parental ESCC cells. It was found that STAT1 can bind to the promoter region of lncRNA PART1, resulting in its activation. Knockdown of lncRNA PART1 potently promoted the gefitinib-induced cell death, while elevated PART1 promoted gefitinib resistance by competitively binding to miR-129 to facilitate Bcl-2 expression in ESCC cells. In addition, extracellular PART1 could be incorporated into exosomes and transmitted to sensitive cells, thus disseminating gefitinib resistance. Clinically, high levels of serum lncRNA PART1 in exosome were associated with poor response to gefitinib treatment in ESCC patients.

Conclusions
LncRNA PART1 promotes gefitinib resistance by regulating miR-129/Bcl-2 pathway, and may serve as a therapeutic target for ESCC patients.
Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
Authors: Huang Yanjun , Zhou Sichun , He Caimei , Deng Jun , Tao Ting , Su Qiongli , Darko Kwame Oteng , Peng Mei , Yang Xiaoping 
Published: July 2018

AbstractBackgroundIn previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or in combination with gefitinib, could inhibit growth of bladder cancer cells.MethodsThe growth‐inhibitory effects of phenformin and gefitinib were tested in one murine and two human bladder cancer cell lines using MTT and clonogenic assays. Effects on cell migration were assessed in a wound healing assay. Synergistic action between the two drugs was assessed using CompuSyn software. The potential involvement of AMPK and EGFR pathways in the effects of phenformin and gefitinib was explored using Western blotting.ResultsIn MTT and clonogenic assays, phenformin was > 10‐fold more potent than metformin in inhibiting bladder cancer cell growth. Phenformin also potently inhibited cell migration in wound healing assays, and promoted apoptosis. AMPK signaling was activated; EGFR signaling was inhibited. Phenformin was synergistic with gefitinib, with the combination of drugs showing much stronger anticancer activity and apoptotic activation than phenformin alone.ConclusionsPhenformin shows potential as an effective drug against bladder cancer, either alone or in combination with gefitinib.
Interpretation of borehole sonic measurements acquired in vertical transversely isotropic formations penetrated by vertical wells
Authors: Maalouf Elsa , Torres-Verdín Carlos 
Published: July 2018

Detecting vertical transversely isotropic (VTI) formations and quantifying the magnitude of anisotropy are fundamental for describing organic mudrocks. Methods used to estimate stiffness coefficients of VTI formations often provide discontinuous or spatially averaged results over depth intervals where formation layers are thinner than the receiver aperture of acoustic tools. We have developed an inversion-based method to estimate stiffness coefficients of VTI formations that are continuous over the examined depth interval and that are mitigated for spatial averaging effects. To estimate the coefficients, we use logs of frequency-dependent compressional, Stoneley, and quadrupole/flexural modes measured with wireline or logging-while-drilling (LWD) instruments in vertical wells penetrating horizontal layers. First, we calculate the axial sensitivity functions of borehole sonic modes to stiffness coefficients; next, we use the sensitivity functions to estimate the stiffness coefficients of VTI layers sequentially from frequency-dependent borehole sonic logs. Because sonic logs exhibit spatial averaging effects, we deaverage the logs by calculating layer-by-layer slownesses of formations prior to estimating stiffness coefficients. The method is verified with synthetic models of homogeneous and thinly bedded formations constructed from field examples of organic mudrocks. Results consist of layer-by-layer estimates of [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text]. We observe three sources of error in the estimated coefficients: (1) bias error originating from deaveraging the sonic logs prior to the sequential inversion, (2) error propagated during the sequential inversion, and (3) error associated with noisy slowness logs. We found that the relative bias and uncertainty of the estimated coefficients are largest for [Formula: see text] and [Formula: see text] because borehole modes exhibit low sensitivity to these two coefficients. The main advantage of our method is that it mitigates spatial averaging effects of sonic logs, while at the same time it detects the presence of anisotropic layers and yields continuous estimations of stiffness coefficients along the depth interval of interest.
Seismic characteristics and sedimentary record of the late Pleistocene delta offshore southwestern Hainan Island, northwestern South China Sea
Authors: Feng Yingci , Zhan Wenhuan , Chen Hongjun , Jiang Tao , Zhang Jinchang , Osadczuk Andrzej , Yao Yantao , Li Wei , Sun Jie , Guo Lei , Huang Wenkai , Li Shun , Zhang Wenyan 
Published: July 2018

A late Pleistocene delta (Hainan palaeo river delta, HNPD hereafter) exceeding [Formula: see text] offshore Hainan Island, northwestern South China Sea (SCS), is investigated using high-resolution seismic and core data to understand the relationship between subaqueous delta development and climate drivers during the Last Glacial Period. The seismic data indicate general progradational configurations toward the southwest or southeast, indicating that the sediments from the eastern slope offshore southwestern Hainan Island were transported southwestward and southeastward. The average thickness of the delta sediment is approximately 35 m, and it has an arcuate shape surrounding the eastern slope. Therefore, the sediment provenances of the HNPD were mainly from the Red River drainage and Hainan Island. Comparison between the core dating results and the global sea-level curve indicates that the delta formed mainly during marine isotope stage 4 (65–56 ka). The topography of the basin, the sea-level change from low stand to high stand, and the southward oceanic currents driven by the glacial-period strong winter monsoon all contributed to the formation of the delta. Because the development of the delta required large riverine sediment input, we speculate that the main reason that the delta’s development ceased was the migration of the river channel along the eastern slope. Based on a comparison between the palaeobathymetric scenarios derived from published sea-level curves and the delta stratigraphy identified from the seismic profiles and cores, we have determined a possible range of relative sea level between 65 and 56 ka for the southwestern coast of Hainan Island, which might also be applicable for a broader region, i.e., the northern SCS.
Rare Case of Transcutaneous Oxygen Desaturation in a Cancer Patient: A Case Report and Diagnostic Approach for a Recurrent Problem
Authors: Bachmann Kaspar F. , Nebiker Mathias , Johner Caroline , Bregy Rachel , Schaller André , Novak Urban , Jakob Stephan M. 
Published: July 2018

We present a case of a 73-year-old cancer patient with low transcutaneous oxygen saturation who was transferred to the intensive care unit after deployment of the rapid response team. Differential diagnosis remained broad until methemoglobinemia (MetHb) was detected.
MetHb was induced by administration of rasburicase, which was given to prevent tumor lysis syndrome. In a follow-up examination, glucose-6-phosphate dehydrogenase deficiency was found to be the cause of MetHb after rasburicase exposure.
Diagnosis was made by either measuring arterial MetHb or CO oximeter. Treatment options involve transfusion and methylene blue, if glucose-6-phosphate dehydrogenase deficiency is not present.
Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in Drosophila melanogaster
Authors: Gupta Alind , Fabian Lacramioara , Brill Julie A. 
Published: July 2018

ABSTRACT
Cilia are cellular antennae that are essential for human development and physiology. A large number of genetic disorders linked to cilium dysfunction are associated with proteins that localize to the ciliary transition zone (TZ), a structure at the base of cilia that regulates trafficking in and out of the cilium. Despite substantial effort to identify TZ proteins and their roles in cilium assembly and function, processes underlying maturation of TZs are not well understood. Here, we report a role for the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in TZ maturation in the Drosophila melanogaster male germline. We show that reduction of cellular PIP2 levels through ectopic expression of a phosphoinositide phosphatase or mutation of the type I phosphatidylinositol phosphate kinase Skittles induces formation of longer than normal TZs. These hyperelongated TZs exhibit functional defects, including loss of plasma membrane tethering. We also report that the onion rings (onr) allele of Drosophila Exo84 decouples TZ hyperelongation from loss of cilium–plasma membrane tethering. Our results reveal a requirement for PIP2 in supporting ciliogenesis by promoting proper TZ maturation.
Mali I, Lopes - 10 Korriku - Theken - Terno ve chromite deposits and their potential
Authors: GJONI V. 
Published: July 2018

Mali Lopes-10 Korriku-Theken-Ternove chromite deposits are located in the Bulqiza ophiolite massif. According to the recent data, it is concluded that this area is a new very prospective target.
‘you’ve told me that three times now’: Propaganda/anti-propaganda in the Films Division India documentary, 1965–75
Authors: Kishore Avijit Mukul 
Published: July 2018

Abstract
In the period from 1965 to 1975, some unprecedented and original experiments with the non-fiction film were conducted within Films Division India (FD), the Indian government’s documentary production organisation. The films of this period are important because they mark the first expression of dissent and resistance to statist agendas of propaganda, as well as to prescriptive ways of making documentary films. This article examines the work of a select group of FD film-makers and their engagement with politics and film form, under the leadership of FD’s then Director, Jehangir Bhownagary. This decade has often been referred to as the ‘golden age’ and the ‘experimental film’ phase of FD, framing the popular understanding of the FD documentary through the binary of ‘nation-building/propaganda films’ or ‘experimentation’. This article analyses the films of this period – from the perspective of a documentary film-maker and curator, with a long-standing engagement with the FD archive – to foreground the critique embedded within experiments with film form, as well as the status quo-ist and regressive nature of some of the highly abstract and unconventional films made in this period. By doing so, the article attempts to pry loose the rigid classifications that have now congealed debates about the FD films, and to offer a more nuanced reading of this material.
The frame as borderland: Secular gazes and believing bodies in Bani Abidi’s The Distance From Here (2010)
Authors: Madani Adnan 
Published: July 2018

Abstract
Is it still possible to think of some contemporary art as belonging to a religious or a secular world, where ‘world’ is understood in Wittgenstein’s sense as all that is the case? What purchase can these powerful concepts have on today’s art, especially in the realm of video and photography with their peculiar relations to reality and subjectivity? Echoing Talal Asad’s question ‘[i]s there a secular body?’, I ask whether there is a ‘secular’ or ‘religious’ gaze that belongs to this body, how it describes its own boundaries and what lies outside it. Looking at Pakistani art allows me to investigate the longer duration of culture from which some recent video practices have emerged and found a place in globalised art circuits. I claim that Bani Abidi’s video art, and specifically The Distance From Here (2010) can be seen as a sustained exploration of heterogeneous temporalities and subjective positions that are as yet not entirely taken up by their international presentation, audience and circulation, and derive from a space that is not understandable as simply divided between the secular and the religious. This remainder or intractability might indicate the possibility of encounters with forms of life that unsettle existing conceptual divisions between the secular and the religious or the local and the global. Seeing Abidi’s work in relation to a powerful tradition of allegory and of narrative deriving from the philosophy of Ibn Sina, I argue that these currents persist in popular culture and in local literary or artistic forms, even when they are not explicitly referred to. This allows me to make a case for seeing Abidi’s work in a context that is not restricted to the history of (Euro-American) art and its philosophies.
Chi
Authors: Mai Luo , Zeng Kai , Potharaju Rahul , Xu Le , Suh Steve , Venkataraman Shivaram , Costa Paolo , Kim Terry , Muthukrishnan Saravanan , Kuppa Vamsi , Dhulipalla Sudheer , Rao Sriram 
Published: July 2018

Stream-processing workloads and modern shared cluster environments exhibit high variability and unpredictability. Combined with the large parameter space and the diverse set of user SLOs, this makes modern streaming systems very challenging to statically configure and tune. To address these issues, in this paper we investigate a novel control-plane design, Chi, which supports continuous monitoring and feedback, and enables dynamic re-configuration. Chi leverages the key insight of embedding control-plane messages in the data-plane channels to achieve a low-latency and flexible control plane for stream-processing systems.
Chi introduces a new reactive programming model and design mechanisms to asynchronously execute control policies, thus avoiding global synchronization. We show how this allows us to easily implement a wide spectrum of control policies targeting different use cases observed in production. Large-scale experiments using production workloads from a popular cloud provider demonstrate the flexibility and efficiency of our approach.
A uterus didelphys with a spontaneous labor at term of pregnancy: a rare case and a review of the literature
Authors: Algeri Paola , Rota Sonia M. , Nicoli Elena , Caruso Orlando , Spinetti Giovanna , Stagnati Valentina 
Published: July 2018

Abstract
Uterus didelphys accounts for 13% of uterine anomalies and has been correlated with preterm delivery and fetal malpresentation at delivery. A 37-year-old pregnant woman reported a spontaneous pregnancy in the right horn of a uterus didelphys. The course of the pregnancy was complicated by gestational diabetes, but no miscarriage threat or preterm delivery threat was reported during this pregnancy. She arrived at our division, in labor, at 39.2 gestational weeks’. She delivered by cesarean section due to failure to progress at 5 cm. Her post-operative course was uneventful. Vaginal delivery could be a safe option and the induction of labor or the use of oxytocin could be helpful in such cases, but recommended doses and labor time should be evaluated, so cesarean section is to date the most frequent delivery route in uterus didelphys at term.
Analyzing the Link Between Agency Problems, Governance and Control Attributes for Pakistan
Authors: Ghazali Ahmad , Bilal Ahmad Raza 
Published: July 2018

Abstract
This research attempts to analyze the relationship between agency, control and corporate governance attributes for a sample of 267 firms listed on the Pakistan Stock Exchange (PSX) from 2005 to 2008. The results show that a) Pakistani listed firms are facing high agency costs problems in contrast to established markets. b) Factors are observed important to having strong effect on mitigating agency costs levels: corporate dividend policy, degree of board independence, and institutional ownership. c) Corporate governance factors reduce discretionary expenditure ratio, increase assets utilization ratio and free cash flow ratio. d) Control variables increases the asset utilization ratio and decreases the free cash flow and increases the managers’ performance (Tobin’s Q ratio). e) Ownership attributes regulate free cash flow and decrease the discretionary expenditure ratio. The outcomes of this research lead to the proposed use of recommended governance, control and ownership attributes to overcome agency problems and a sound policy for better corporate governance (better management of agency cost issues) for listed firms.
Geotourism starts with accessible information: the Internet as a promotional tool for the georesources of Lower Silesia
Authors: Widawski Krzysztof , Rozenkiewicz Agnieszka , Łach Janusz , Krzemińska Alicja , Oleśniewicz Piotr 
Published: July 2018

Abstract
This paper investigates the state of information on geoheritage or, in a wider perspective, a geotourist offer that can be found on the Internet, the basic source of information for the potential tourist, at the example of Lower Silesia. In order to achieve the intended aim, firstly a discussion concerning the division of the tourist resources in the literature was presented. It served as the starting point for the selection and analysis of particular resources, and their online promotion techniques. A place of the geotourist resources within this group was highlighted. Next, the analysis of official documents that constitute the basis for actions aimed at the promotion of tourist resources, with the geotourist ones in particular, was carried out. Predominantly, they comprised the strategies of tourism development at different levels, i.e. the level of voivodeship, and the selected counties, where crucial georesources, or geoheritage complexes of the region are located. One of the most important examples is the Kłodzko County, officially referred to in its strategy as “the Tourist County.” The authors also indicated the nature-based tourist resources of Lower Silesia, placing special emphasis on the resources presented in the Geotourist Catalogues - the most comprehensive presentations of this kind of resources in Poland. In the following part, another analysis was presented regarding information on natural resources promoted on the websites of public administration, or local authorities. Selected websites were examined for their accessibility and the manner in which the georesources are presented. The main result of the conducted research is highlighting the fact that geotourism as a distinctive tourism category is not sufficiently promoted online. The reason behind it is the dispersion of geotourist resources being categorised under divergent umbrella terms. A set of actions for the implementation of changes that can possibly improve the present situation was suggested.
A synergetic effect of ionic liquid and microwave irradiation on the acid-catalyzed direct conversion of cellulose into methyl glucopyranoside
Authors: Saito Mafuyu , Kishimoto Takao , Hamada Masahiro , Nakajima Noriyuki , Urabe Daisuke 
Published: July 2018

Abstract
Conversion of lignocellulose into useful chemicals is an important research topic in the area of biomass utilization. In this study, microcrystalline cellulose (MC) was dissolved in a mixed-solvent system containing the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl) and N-methyl-pyrrolidone (NMP), and the cellulose was directly converted into methyl glucoside (MG) by acid-catalyzed methanolysis aided by microwave irradiation (μWIr). Under moderate reaction temperature and pressure, and in the presence of acetyl chloride/methanol (in situ formed HCl) as an acid catalyst, MG was obtained in a 42% yield. In contrast, in the absence of either IL or μWIr, the MG yield was only 5 or 21%, respectively. Both μWIr and the dissolution of cellulose in IL were quite effective for the conversion of cellulose into MG.
Erhebung syntaktischer Fähigkeiten von Kindern mit Deutsch als Zweitsprache: Ein Methodenvergleich.
Authors: Geist Barbara 
Published: July 2018

Zusammenfassung
Ziel dieser Studie ist es festzustellen, ob Kinder in einer Bilderbeschreibungs- und einer Satzvervollständigungsaufgabe die gleichen Ergebnisse in der Produktion deutscher Haupt- (Verbzweitstellung) und Nebensätze (Verbendstellung) erzielen. 47 Kinder (primär mit Deutsch als Zweitsprache) wurden hierzu mit HAVAS 5 und LiSe-DaZ getestet. Trotz einer signifikanten Korrelation zwischen den syntaktischen Fähigkeiten (gemessen als Produktion von Haupt- und Nebensätzen bzw. Verbstellung) in beiden Methoden zeigen die Ergebnisse, dass die beiden Methoden nicht die gleichen Informationen über die Haupt- und Nebensatzproduktion der Kinder zur Verfügung stellen (Übereinstimmung 68 %). 14 Kinder produzieren zwar in der Satzvervollständigungsaufgabe, nicht jedoch in der Bilderbeschreibungsaufgabe Nebensätze mit Verbendstellung. Die Gefahr, syntaktische Fähigkeiten mit einer Bilderbeschreibungsaufgabe zu unterschätzen, wird diskutiert.
Berufsbezogene Bildungssprache: Praktiken der Wissensdarbietung in Prüfungsgesprächen der Pflegeausbildung
Authors: Amorocho Simone 
Published: July 2018

ZusammenfassungDer Beitrag, dem eine Teilnehmersicht auf Bildungssprache zugrunde liegt (emische Perspektive), beschreibt Praktiken der Wissensdarbietung in Prüfungsgesprächen der Pflegeausbildung am Material von zwei inhaltlich vergleichbaren Prüfungsausschnitten. Die dabei rekonstruierten Unterschiede zwischen den beiden Kandidatinnen werden zu den Erwartungen der Prüfenden in Beziehung gesetzt. Dadurch kann gezeigt werden, dass die Normen nicht vollständig mit der abstrakten Idealvorstellung des bildungssprachlichen Registers übereinstimmen, sondern dass das berufsbezogene Setting mit spezifischen bildungssprachlichen Praktiken einhergeht.