bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcome and survival of metal-on-metal hip resurfacing in patients aged less than 50 years
Authors: Scholes C. J. , Ebrahimi M. , Farah S. B. , Field C. , Cordingley R. , Kerr D. , Kohan L. 
Published: January 2019

AimsThe aim of this study was to report the implant survival and patient-reported outcome measures (PROMs) in a consecutive series of patients aged less than 50 years at the time of arthroplasty using the Birmingham Hip Resurfacing system (BHR), with a minimum follow-up of ten years.Patients and MethodsA total of 226 patients with osteoarthritis of the hip, who underwent BHR and presented to a single surgeon, were included in the study. Survival of the implant was confirmed by cross-checking with the Australian Orthopaedic Association National Joint Replacement Registry. Kaplan–Meier survival curves with 95% confidence intervals (CIs) were constructed. Pre- and postoperative PROMs were compared with t-tests, and postoperative scores were compared using anchor analysis with age and gender matched normative data.ResultsAt median follow-up of 12 years (interquartile range (IQR) 10 to 13), six BHRs were revised, with a cumulative rate of survival of 96.8% (95% confidence interval (CI) 94.2 to 99.4) at 15 years, and with a significantly lower (p = 0.019) cumulative rate of revision than the national average for the same device at ten years. Most revisions (n = 4) were undertaken early, less than three years postoperatively, and occurred in women. Patient-reported general health (Veteran’s Rand-36), disease state (Western Ontario and McMaster Universities Osteoarthritis Index), function (modified Harris Hip Score) and level of activity (Tegner activity score) maintained significant (p < 0.01 for each) improvements beyond ten years postoperatively and were equal to, or exceeded, age- and gender-matched normative data in more than 80% of the patients.ConclusionLonger term PROMs after BHR, from a single surgeon, for patients aged less than 50 years remain under-reported. We found that the outcome after a BHR, at a minimum of ten years postoperatively, remained satisfactory, particularly for self-reported hip function.
Low predictive power of comorbidity indices identified for mortality after acute arthroplasty surgery undertaken for femoral neck fracture
Authors: Bülow E. , Cnudde P. , Rogmark C. , Rolfson O. , Nemes S. 
Published: January 2019

Aims Our aim was to examine the Elixhauser and Charlson comorbidity indices, based on administrative data available before surgery, and to establish their predictive value for mortality for patients who underwent hip arthroplasty in the management of a femoral neck fracture. Patients and Methods We analyzed data from 42 354 patients from the Swedish Hip Arthroplasty Register between 2005 and 2012. Only the first operated hip was included for patients with bilateral arthroplasty. We obtained comorbidity data by linkage from the Swedish National Patient Register, as well as death dates from the national population register. We used univariable Cox regression models to predict mortality based on the comorbidity indices, as well as multivariable regression with age and gender. Predictive power was evaluated by a concordance index, ranging from 0.5 to 1 (with the higher value being the better predictive power). A concordance index less than 0.7 was considered poor. We used bootstrapping for internal validation of the results. Results The predictive power of mortality was poor for both the Elixhauser and Charlson comorbidity indices (concordance indices less than 0.7). The Charlson Comorbidity Index was superior to Elixhauser, and a model with age and gender was superior to both indices. Conclusion Preoperative comorbidity from administrative data did not predict mortality for patients with a hip fracture treated by arthroplasty. This was true even if association on group level existed.
O VOCABULÁRIO REGIONAL DO ESCRITOR ARIANO SUASSUNA NA OBRA FARSA DA BOA PREGUIÇA
Authors: Oliveira Uelida Dantas de , Aragão Maria Do Socorro Silva de 
Published: January 2019

Nesta pesquisa apresentamos um estudo léxico-semântico das expressões regionais que fazem parte da linguagem usada pelo escritor Ariano Suassuna. Objetivamos analisar as escolhas lexicais do autor na obra Farsa da Boa Preguiça (2014), com a intenção de elaborar um vocabulário, no qual explanamos as expressões selecionadas na obra, suas definições conforme confirmam os dicionários de língua portuguesa e os dicionários de expressões regionais nordestinos. Para o desenvolvimento do estudo usaremos como fundamentação teórica o léxico e suas ciências, visando o auxílio na elaboração do vocabulário e refletindo a respeito do falar regional, considerando que a linguagem utilizada por Ariano Suassuna é um reflexo da interação entre sociedade e cultura. Sendo assim, a apresentação do conteúdo lexical presente na obra por meio de um vocabulário torna possível a compreensão da relação sociedade e cultura que transfere para a linguagem do indivíduo o reflexo da sua influência.
Circulating Tumor Cells in Prostate Cancer: From Discovery to Clinical Utility
Authors: Pantel Klaus , Hille Claudia , Scher Howard I 
Published: January 2019

Abstract

BACKGROUND
Prostate cancer represents the most common non–skin cancer type in men. Unmet needs include understanding prognosis to determine when intervention is needed and what type, prediction to guide the choice of a systemic therapy, and response indicators to determine whether a treatment is working. Over the past decade, the “liquid biopsy,” characterized by the analysis of tumor cells and tumor cell products such as cell-free nucleic acids (DNA, microRNA) or extracellular vesicles circulating in the blood of cancer patients, has received considerable attention.

CONTENT
Among those biomarkers, circulating tumor cells (CTCs) have been most intensively analyzed in prostate cancer. Here we discuss recent studies on the enumeration and characterization of CTCs in peripheral blood and how this information can be used to develop biomarkers for each of these clinical contexts. We focus on clinical applications in men with metastatic castration-resistant prostate cancer, in whom CTCs are more often detected and at higher numbers, and clinical validation for different contexts of use is most mature.

SUMMARY
The overall goal of CTC-based liquid biopsy testing is to better inform medical decision-making so that patient outcomes are improved.
Effects of Gender-Affirming Hormones on Lipid, Metabolic, and Cardiac Surrogate Blood Markers in Transgender Persons
Authors: Defreyne Justine , Van de Bruaene Laurens D L , Rietzschel Ernst , Van Schuylenbergh Judith , T'Sjoen Guy G R 
Published: January 2019

AbstractBACKGROUNDGender-affirming hormonal therapy consists of testosterone in transgender men and estrogens and antiandrogens in transgender women. Research has concluded that gender-affirming therapy generally leads to high satisfaction rates, increased quality of life, and higher psychological well-being. However, given the higher incidence of cardiometabolic morbidity and mortality in cisgender men compared with cisgender women, concerns about the cardiometabolic risk of androgen therapy have been raised.CONTENTA literature research was conducted on PubMed, Embase, and Scopus, searching for relevant articles on the effects of gender-affirming hormone therapy on cardiometabolic risk and thrombosis. After screening 734 abstracts, 77 full text articles were retained, of which 11 were review articles.SUMMARYStudies describing a higher risk for cardiometabolic and thromboembolic morbidity and/or mortality in transgender women (but not transgender men) mainly covered data on transgender women using the now obsolete ethinyl estradiol and, therefore, are no longer valid. Currently, most of the available literature on transgender people adhering to standard treatment regimens consists of retrospective cohort studies of insufficient follow-up duration. When assessing markers of cardiometabolic disease, the available literature is inconclusive, which may be ascribed to relatively short follow-up duration and small sample size. The importance of ongoing large-scale prospective studies/registries and of optimal management of conventional risk factors cannot be overemphasized.
Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis
Authors: Khan Jenna , Schmidt Robert L , Spittal Matthew J , Goldstein Zil , Smock Kristi J , Greene Dina N 
Published: January 2019

Abstract

BACKGROUND
Transgender women are female individuals who were recorded men at birth based on natal sex. Supporting a person's gender identity improves their psychological health, and gender-affirming hormones reduce gender dysphoria and benefit mental health. For transgender women, estrogen administration has clinically significant benefits. Previous reviews have reported conflicting literature on the thrombotic risk of estrogen therapy in transgender women and have highlighted the need for more high-quality research.

CONTENT
To help address the gap in understanding thrombotic risk in transgender women receiving estrogen therapy, we performed a systematic literature review and metaanalysis. Two evaluators independently assessed quality using the Ottawa Scale for Cohort Studies. The Poisson normal model was used to estimate the study-specific incidence rates and the pooled incidence rate. Heterogeneity was measured using Higgins I2 statistic. The overall estimate of the incidence rate was 2.3 per 1000 person-years (95% CI, 0.8–6.9). The heterogeneity was significant (I2 = 74%; P = 0.0039).

SUMMARY
Our study estimated the incidence rate of venous thromboembolism in transgender women prescribed estrogen to be 2.3 per 1000 person-years, but because of heterogeneity this estimate cannot be reliably applied to transgender women as a group. There are insufficient data in the literature to partition by subgroup for subgroup prohibiting the analysis to control for tobacco use, age, and obesity, which is a major limitation. Additional studies of current estrogen formulations, modes of administration, and combination therapies, as well as studies in the aging transgender population, are needed to confirm thrombotic risk and clarify optimal therapy regimens.
EFEKTIVITAS PELATIHAN MEDITASI PERNAFASAN DALAM MENURUNKAN TINGKAT STRES PADA PENDUKUNG SEBAYA ODHA
Authors: Fendina Fella , Nashori Fuad , Sulistyarini Indahria 
Published: January 2019

Stress is particularly at risk for physical condition, psychological, and productivity of ODHA's peer support. This research aims to determine the effectiveness of breathing meditation training to reduce stress level on ODHA's peer support. The research was conducted at Yogyakarta X foundation on 14 peer supporters which divided into two groups, namely group of experimental and group of control. This research used Quasi Experimental Pretest-Posttest Control Group Design. Research data will be analyzed using ANAVA MIX statistical technique. The result showed there was a significant differentiation between the experimental group and the control group. From this research also known that the Effect Size of breathing meditation training on stress decrease equal to 64%. Thus it can be stated that breathing meditation training is effective in reducing stress on peer support of ODHA. Keywords : Stress, Breathing Meditation, Peer Support of ODHA
EVALUATION AND FREQUENCY OF KELL ERYTHROCYTE ANTIGEN IN BLOOD DONORS OF REGIONAL BLOOD CENTER OF PASSO FUNDO, BRAZIL
Authors: Baldasso Danury Dal Piva , Mandelli Jéssica Zolim Andreatto , Ehrhardt Anelise , Boehm Renata Eliane , Ehrhardt Alexandre 
Published: January 2019

The aim of this research was verify the frequency of erythrocyte antigen K1 in the population of donors who had their blood phenotyped at Regional Blood Center of Passo Fundo (RS). This descriptive study of documental approach was conduct through retrospective evaluation of record spreadsheets for all donors phenotyped during the period of July 2010 to June 2015. An absolute verification was done, comparing the number of donors without the expressed antigen KELL and the number of donors who had this antigen on the erythrocyte membrane. From 1,163 phenotyped donors, 80 (7%) showed antigen expression in the erythrocyte membrane, being lower number than reported in the literature. Despite the percentage found for the K1 expression be lower than is described by other authors, the antigen must be identified because its immunogenicity has great clinical relevance and may result in transfusion complications.
COLECALCIFEROL: UMA ANÁLISE CRÍTICA DE PRODUTOS MANIPULADOS E INDUSTRIALIZADOS
Authors: Chagas Stephanye Carolyne Christino , Ferrucci Maria Amélia Paiva , Carvalho Julia Celly de Morais , Souza Asley Thalia Medeiros , De Santana Davi Pereira , Leal Leila Bastos 
Published: January 2019

Profissionais de saúde tem prescrito cada vez mais vitamina D, visto que sua deficiência representa um problema de saúde coletiva mundial. Adicionalmente, indivíduos têm utilizado esta substância para outros fins além daqueles ligados ao metabolismo mineral, apesar da escassez de dados científicos sobre seu papel na prevenção de outras doenças. Este trabalho analisou a prescrição, manipulação e uso do colecalciferol em apresentações magistrais e comerciais nacionais. Farmácias magistrais de Recife, PE informaram as formas farmacêuticas manipuladas contendo colecalciferol para administração oral; consultas eletrônicas ao site da Anvisa e ao software INTUITIVE®, utilizado pela Farmácia Escola Carlos Drummond de Andrade (FECDA), permitiram que as apresentações comerciais/manipuladas, no período do estudo, fossem elencadas e analisadas. Foram realizadas consultas a bases de dados visando estabelecer uma análise crítica e atual diante dos achados. Foi verificada uma ampla preocupação no estabelecimento dos níveis sanguíneos adequados desta vitamina na população por parte dos profissionais de saúde habilitados, visto que 29 diferentes especialistas prescreveram colecalciferol manipulado. Também foi constatada uma maior quantidade de dosagens e formas farmacêuticas magistrais quando comparadas com as apresentações comerciais do mercado nacional. No mais, garantir que estas prescrições estejam embasadas nas necessidades de cada paciente, requer exames sanguíneos e utilização de guias reconhecidos, o que, associado ao acompanhamento farmacoterapêutico, poderá contribuir para o sucesso terapêutico.
ESTUDO FARMACOTERAPÊUTICO, EPIDEMIOLÓGICO E IMPACTO ECONÔMICO DA ASMA EM UNIDADES DE SAÚDE BRASILEIRAS: UMA REVISÃO NARRATIVA
Authors: Melo Cícero Erison dos Santos Espíndola , Barros Gabriel Romero Melo do Rêgo , Silva Lucas Vinícius Rodrigues de Alcântara , Neves Ana Cláudia Florêncio , Santos Rosiel José dos 
Published: January 2019

A asma é uma doença multifatorial que atinge todas as idades principalmente nos primeiros anos de vida, impactando a saúde e sobrecarregando o Sistema Único de Saúde (SUS). Os medicamentos para essa doença são distribuídos pelo serviço público por meio do Componente Especializado da Assistência Farmacêutica (CEAF). O farmacêutico surge nesse âmbito para identificar, prevenir e solucionar os problemas relacionados ao medicamento. O objetivo desse trabalho foi evidenciar as características epidemiológicas e fisiopatológicas da asma, relatando os principais tratamentos e atuação da assistência farmacêutica. Trata-se de um estudo de revisão narrativa, utilizando as bases de dados SciELO, ScienceDirect, PubMed e Google Acadêmico, onde foi realizada a busca ativa de artigos originais, no período de 2007 a 2017. Além disso, foi feito um levantamento no Sistema de Informações Hospitalares do SUS relativo ao quantitativo de internações e custos frente a esses pacientes. A asma é uma doença crônica e inflamatória, prevalente em mulheres (50,74%) e faixa etária de 0–9 anos de idade (52,45%), sendo as regiões Nordeste e Norte as que apresentam maior número de óbitos. A farmacoterapia mais utilizada no tratamento da asma é a associação de corticoides inalatórios (CI) com β2-agonistas de ação prolongada, representados, principalmente, por formoterol e budesonida. Foi possível verificar neste estudo que o farmacêutico, no cenário da asma, tem papel importante no acompanhamento farmacoterapêutico contribuindo para uma melhor qualidade de vida desses pacientes.
The Green Economy in Market-Oriented Countries: The Case of Kazakhstan
Authors: NURGALIYEVA Kuralay Orazgalievna , AMIROVA Ainur Uyizbaevna , NURTAZINOVA Akbayan Serikovna 
Published: January 2019

A social market economy is predicated on the principle that sustainable development is possible only if there is a solid focus on key economic, social, and environmental issues. The purpose of the research reported in this paper is to explore the outcomes of market reforms related to the shift to a green economy in the Republic of Kazakhstan.
The findings from the authors’ study indicate that today the Kazakh economy is one of the world’s most energy-intensive economies, which is due to the use of outmoded infrastructure, technology, and standards, most of which were inherited from as early as the Soviet period. As a result of its market reforms, Kazakhstan has experienced tangible economic growth, but the nation’s environmental indicators remain a serious concern in relation to the health of its citizens. In the Environmental Performance Index (EPI), Kazakhstan has fallen far behind not only most developed market-oriented countries but some of the developing nations that used to be part of the former Soviet Union as well, like Russia, Belarus, Armenia, Turkmenistan, and others.
To galvanize the process of shifting to a “green” economy in the Republic of Kazakhstan, it may help to implement some of the new instruments that have been employed as part of environmental policy in certain market-oriented countries and have proven to be efficient. These instruments and approaches include environmental taxes and levies, permit trading systems, deposit return systems, environmentally motivated subsidies, and organizations and enterprises displaying a willing, voluntary attitude toward improving their environmental performance.
Enhancing Students’ Logical-Thinking Ability in Natural Science Learning with Generative Learning Model
Authors: Riyanti Henni , Suciati Suciati , Karyanto Puguh 
Published: January 2019

The logical-thinking ability is one of the important competencies of 21st century that should be empowered. It is one of the aspects in a cognitive science domain that has not been implemented effectively in teaching and learning in the class. Then, this study aimed to analyzed the influence of generative learning model to enhance students' logical-thinking ability. This study was also conducted by using a quasi-experimental study with pretest-posttest non-equivalent control group design. The sample was chosen by using simple random sampling technique. This study involved two classes which had 67 participants consisting of 34 students in Class VIII.9 as an experimental group and 33 students in Class VIII.7 as a control group. The researcher used the instrument of logical-thinking ability formulated in the form of multiple choice tests with five alternative answers that had been tested for its validity and reliability. The analysis of data employed t-test using SPSS 21. The result indicated that the t-count > t-table (2.44 > 1.99) and p-value = 0.017 (p <0.05). It could be concluded that the application of generative learning model resulted in a significant influence on students' logical-thinking ability. The result of the analysis could be used by the schools for evaluating the quality of natural science learning in order to encourage students’ logical-thinking ability.
Rituximab treatment for isolated IgG4-related hypophysitis in a teenage female
Authors: Bullock Danielle R , Miller Bradley S , Clark H Brent , Hobday Patricia M 
Published: January 2019

Summary
IgG4-related hypophysitis is an important diagnostic consideration in patients with a pituitary mass or pituitary dysfunction and can initially present with headaches, visual field deficits and/or endocrine dysfunction. Isolated IgG4-related pituitary disease is rare, with most cases of IgG4-related disease involving additional organ systems. We report the case of a teenage female patient with isolated IgG4-related hypophysitis, diagnosed after initially presenting with headaches. Our patient had no presenting endocrinologic abnormalities. She was treated with surgical resection, prednisolone and rituximab with no further progression of disease and sustained normal endocrine function. This case, the youngest described patient with isolated IgG4-related hypophysitis and uniquely lacking endocrinologic abnormalities, adds to the limited reports of isolated pituitary disease. The use of rituximab for isolated pituitary disease has never been described. While IgG4-related hypophysitis has been increasingly recognized, substantial evidence concerning the appropriate treatment and follow-up of these patients is largely lacking.

Learning points:

IgG4-related hypophysitis most often occurs in the setting of additional organ involvement but can be an isolated finding. This diagnosis should therefore be considered in a patient presenting with pituitary abnormalities.

Most patients with IgG4-related hypophysitis will have abnormal pituitary function, but normal functioning does not exclude this diagnosis.

Corticosteroids have been the mainstay of therapy for IgG4-related disease, with other immunosuppressive regimens being reserved for refractory cases. Further research is needed to understand the effectiveness of corticosteroid-sparing regimens and whether there is utility in using these agents as first-line therapies.
The Influence of Intellectual Capital and Knowledge Management on Organizational Performance in Lithuanian Software Companies
Authors: Atkočiūnienė Zenona , Praspaliauskytė Greta 
Published: January 2019

[full article and abstract in English]
In the contemporary information and knowledge society, it is important to evaluate the intangible organizational resources that generate long-term value for organizations. Among others, these include intellectual capital and management of knowledge. The research fields of intellectual capital and knowledge management address such issues as (but not limited to) the abilities of employees to create and accumulate knowledge, share and apply it in everyday activities, develop new, sustainable and long-term relationships with various stakeholders. During the last decade, there has been a shift in research toward linking these two previously separate fields of activity in order to demonstrate their interrelations and influence on organizational performance. However, this is problematic due to the difficulties of expressing the value of intellectual capital and knowledge management in a tangible form. The aim of this article is to analyze and define the influence of intellectual capital and knowledge management on organizational performance. For this task, we built a conceptual model for assessing the influence of intellectual capital and knowledge management on organizational performance, which was applied in a study conducted in IT companies operating in Lithuania.