bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bicarbonate-Buffered Dialysate on Ventricular Arrhythmias in Hemodialysis Patients
Authors: Krahn Ryan E. , Tulowitzki Ryan , Gudleski Gregory D. , Murray Brian , Rajagopalan Bharath , Su Winnie , Muscarella Mary , Lambert Judy , Curtis Anne B. , Panesar Mandip 
Published: January 2019

<b><i>Background:</i></b> The etiology of sudden cardiac death in patients with end-stage renal disease (ESRD) on hemodialysis (HD) is largely unknown, though there is evidence to suggest that metabolic alkalosis induced by HD with a high-bicarbonate dialysate/prescription may play a role. <b><i>Methods:</i></b> We investigated the effects of metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate on frequency of ventricular arrhythmia in 47 patients with ESRD on chronic HD using 48-h Holter monitoring in 3 phases: intra-HD, post-HD day 1, and post-HD day 2. Serum levels of bicarbonate, calcium, and potassium along with hemodynamics were measured pre-HD, post-HD, 20-h post-HD, and 44-h post-HD. Correlations were performed to verify the association between bicarbonate prescription and change in serum bicarbonate levels post-HD and to determine if the HD-induced change in serum bicarbonate level (metabolic alkalosis) had any direct association with ambient ventricular arrhythmia (premature ventricular contractions per hour) or indirect associations with ambient ventricular arrhythmia by affecting electrolytes or hemodynamics that are known to increase the risk of ventricular arrhythmia. <b><i>Results:</i></b> Mean pre-HD serum bicarbonate level was 21.3 mEq/L. Dialysate bicarbonate prescription (mean of 36.4 mEq/L) correlated with changes in serum bicarbonate levels immediately post-HD 26.7 mEq/L (<i>r</i> = 0.46, <i>p</i> &#x3c; 0.01), 20-h post-HD 25.2 mEq/L (<i>r</i> = 0.38), and 44-h post-HD 23.2 mEq/L (<i>r</i> = 0.35, <i>p</i> = 0.01). No statistically significant correlations were found between the post-HD change in serum bicarbonate levels (metabolic alkalosis) with ambient ventricular arrhythmia, changes in serum calcium, potassium, or hemodynamics in any phase. <b><i>Conclusions:</i></b> High-bicarbonate dialysate prescription is associated with metabolic alkalosis following the HD procedure. A mild metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate solution had no direct association with ambient ventricular arrhythmia on Holter monitoring and was not associated with changes in hemodynamics or changes in serum total calcium or potassium levels. This study helps to provide guidance for the safe use of high bicarbonate dialysate/prescription in patients with ESRD on HD.
Mecanismo de colocação e auréola termal provocada pelo plúton Ediacarano Catingueira, Província Borborema, Nordeste do Brasil
Authors: Cunha José Alexandre Paixão da , Souza Zorano Sérgio de , Moreira José Antônio De Morais , Valcácio Samir Do Nascimento 
Published: January 2019

O plúton Catingueira, com área de aproximadamente 12 km2, é um granito peralcalino Ediacarano situado entre o Terreno Piancó-Alto Brígida e a Zona de Cisalhamento Patos, Província Borborema (NE Brasil). A intrusão formou uma auréola metamórfica em rochas metapelíticas da Formação Santana dos Garrotes. O presente trabalho trata da caracterização desse efeito termal, usando relações de campo, petrografia, química mineral e propriedades petrofísicas (condutividade térmica, calor específico, difusividade térmica e densidade). Utilizando-se o geotermômetro de zircônio em rochas peralcalinas, calculou-se o valor médio de 760 ± 18ºC para a temperatura inicial do magma. A colocação do plúton é marcada por: verticalização de estruturas de baixo ângulo da encaixante metassedimentar, as quais adquirem direção próxima de E-W, concordante com milonitos da Zona de Cisalhamento Patos; metamorfismo de alta temperatura (450–610ºC) e baixa pressão (3 kbar) cujo efeito é sentido a até 2,5 km do contato, com desenvolvimento da associação biotita ± granada ± estaurolita ± cordierita± sillimanita (+ clorita + muscovita). A modelagem numérica do regime térmico provocado pela intrusão foi feita por meio do software HEAT3D. As simulações foram calculadas a partir de duas formas geométricas, um cilindro vertical e um paralelepípedo horizontal, usando gradientes geotérmicos variando de 30 a 50ºC/km. Para atingir o equilíbrio térmico, foram calculados tempos de resfriamento de 781, 1.032 e 1.127 mil anos. O gradiente que permitiu atingir o melhor ajuste para o modelo foi de 50ºC/km, resultando 1.127 mil anos. Os resultados aqui obtidos em termos de dimensão, forma, profundidade e associações metamórficas são comparáveis a exemplos de outros corpos plutônicos descritos na Província Borborema.
Geocronologia U-Pb, classificação e aspectos evolutivos do Granito Marajoara, Província Carajás
Authors: Santos Rodrigo Fabiano Silva , Oliveira Davis Carvalho de , Silva Fernando Fernandes da 
Published: January 2019

O Granito Marajoara (GrMj) é um stock intrusivo em granitoides mesoarqueanos do Domínio Rio Maria (DRM) da Província Carajás (PC). É formado por rochas leucocráticas: biotita monzogranito equigranular (BMzE) e heterogranular (BMzH). Textura rapakivi e enclaves de granito porfirítico (EGp) e microgranulares (EMg) são restritos à fácies BMzH. Os valores de susceptibilidade magnética (SM) e a presença de magnetita aproximam a fácies BMzH dos granitos da série magnetita, enquanto a variedade BMzE mostra afinidade com aqueles da série ilmenita por apresentar baixos valores de SM e opacos. São granitos peraluminosos similares aos ferroan. Mostram, ainda, afinidades com os granitos tipo-A oxidados (BMzH e EGp) e reduzidos (BMzE), como aquelas dos plútons das suítes Jamon e Velho Guilherme, respectivamente. Os EMg mostram afinidade com os granitos magnesianos e da série calcioalcalina, e os EGp são originados a partir da interação entre os líquidos EMg e BMzH. Os gaps composicionais entre as diversas variedades sugerem que seus magmas não são cogenéticos. Os EMg são representantes de um magmatismo básico oriundo do manto litosférico enriquecido e que teriam sido injetados na câmara magmática por underplating. As análises U-Pb em zircão (SHRIMP) fornecem idade de cristalização (1885 ± 6 Ma). O GrMj foi colocado em epizona em um ambiente de tectônica extensional. A zonalidade concêntrica do GrMj e a influência reduzida dos esforços regionais indicam que o transporte do magma se deu por diques. Dessa forma, a edificação do GrMj é resultante de ascensão vertical de magmas por meio de fraturas e acomodação ao longo dos planos da foliação regional E-W, seguida de uma mudança do fluxo vertical por um espalhamento lateral do magma.
Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment–Elevation Myocardial Infarction
Authors: Tan Yu , Sheng Zhaoxue , Zhou Peng , Liu Chen , Zhao Hanjun , Song Li , Li Jiannan , Zhou Jinying , Chen Yi , Wang Laiyuan , Qian Haiyan , Sun Zhongwei , Qiao Shubin , Xu Bo , Gao Runlin , Yan Hongbing 
Published: January 2019

Background:
Trimethylamine N-oxide (TMAO) is reported to promote the pathogenesis of atherosclerosis and be associated with cardiovascular events risk. It is unknown whether plasma TMAO is associated with plaque morphology in patients with acute myocardial infarction. We investigated the relationship between the culprit plaque morphology and plasma TMAO concentration in patients with ST-segment–elevation myocardial infarction.

Methods and Results:

A prospective series of 211 patients with ST-segment–elevation myocardial infarction who underwent preintervention optical coherence tomography examination for the culprit lesion were enrolled; 77 and 69 patients were categorized as plaque rupture and plaque erosion, respectively. Plasma TMAO levels, detected using stable isotope dilution liquid chromatography tandem mass spectrometry, were significantly higher in patients with plaque rupture than in those with plaque erosion (3.33 μM; interquartile range: 2.48–4.57 versus 1.21 μM; interquartile range: 0.86–1.91;
P
<0.001). After adjustments for traditional risk factors, elevated TMAO levels remained independently correlated with plaque rupture (adjusted odds ratio: 4.06, 95% CI, 2.38–6.91;
P
<0.001). The area under the receiver operating characteristic curve for plaque rupture versus plaque erosion was 0.89. At a cutoff level of 1.95 μM, TMAO had a sensitivity of 88.3% and specificity of 76.8% in discriminating plaque rupture from plaque erosion.

Conclusions:
High levels of plasma TMAO independently correlated with plaque rupture in patients with ST-segment–elevation myocardial infarction. Moreover, TMAO might be a useful biomarker for plaque rupture to improve risk stratification and management in patients with ST-segment–elevation myocardial infarction.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifiers: NCT03593928.
O sumieniu granic
Authors: Szwat-Gyłybowa Grażyna 
Published: January 2019

On the conscience of bordersThis article reflects on the paradoxes inherent in our thinking on liminal territories, which ranges from affirmation to contestation. Its metaphorical title paraphrases Elias Canetti’s idea of the “conscience of words” and brings into focus the connection between discussions of borders and limits on the one hand, and the moral sensitivity of the members and cultural descendants of Judeo-Christian culture on the other. The ways in which people conceptualise borders and limits are presented from the perspective of the beginning (in the Gadamerian sense), i.e. the Bible, and the end (including, for example, Bauman’s concept of “liquid modernity” and Agamben’s post-secular idea of reality as a “camp”). The article concludes with a presentation of how the concepts of liminality and borders are presented (often metaphorically) by sociologists and linguists conducting field studies in Poland’s eastern and western borderlands. O sumieniu granicW artykule podjęto próbę refleksji na temat paradoksów ludzkiego myślenia o granicach terytoriów, rozpiętego między afirmacją a kontestacją. Tytułowa parafraza konceptu Canettiego („sumienie słów”) ma charakter metaforyczny i służy wydobyciu związku mówienia o granicach z wrażliwością moralną ludzi należących do kręgu kultury judeochrześcijańskiej lub będących jej dziedzicami. Sposoby konceptualizowania granic przedstawiono z perspektywy ustanowionego (w sensie Gadamerowskim) początku (Biblia) i końca (m.in. koncepcja „płynnej nowoczesności” Baumana czy „świata-obozu” w postsekularnej myśli Agambena). Tekst zamyka prezentacja ujęć zjawiska graniczności/pograniczności (i towarzyszących temu metaforyzacji) w myśli socjologów i językoznawców prowadzących badania terenowe na wschodnich i zachodnich rubieżach Polski.
A challenge to collective memory: Yitskhok Rudashevski’s "Diary of the Vilna Ghetto"
Authors: Kvietkauskas Mindaugas 
Published: January 2019

A challenge to collective memory: Yitskhok Rudashevski’s Diary of the Vilna GhettoThis article aims to analyse the diary of Yitskhok Rudashevski (1927–1943), the story of its writing and publication and the existing biographical material about the author. It attempts to answer the question of what is or could be the significance of this lieu de mémoire for the current developments in Holocaust memory culture in Lithuania. The adopted definitions of cultural and collective memory and sites of memory are based on the concepts proposed by Jan and Aleida Assmann and Pierre Nora. On the one hand, the diary written by a child in the Vilnius ghetto is of major documentary, moral and aesthetic significance and stimulates individual empathy. On the other hand, the text raises acute issues reflecting a conflict between different memory narratives and interpretations of history. Pro-Soviet sympathies of the author, negative imagery of Lithuanians and certain deheroisation of the ghetto community make the text a “problematic” memory site. These challenges of the diary are interpreted as indicators showing whether contemporary Holocaust narrative in Lithuania is already mature enough to accept the dialogical forms of cultural memory. Wyzwanie dla pamięci zbiorowej: Pamiętnik z wileńskiego getta Icchaka RudaszewskiegoTematem niniejszego artykułu jest analiza dziennika napisanego w getcie przez czternastoletniego Icchaka Rudaszewskiego (1927–1943), historia jego powstania, publikacji i zachowania dla przyszłych pokoleń, a także materiał biograficzny dotyczący postaci autora. Artykuł jest próbą odpowiedzi na pytanie, jakie jest i jakie mogłoby być znaczenie tego miejsca pamięci (lieu de mémoire) w kształtującej się obecnie na Litwie kulturze pamięci Holocaustu. Badania pamięci kulturowej i zbiorowej, a także miejsc pamięci, zostały oparte na koncepcjach badawczych Jana i Aleidy Assmanów oraz Pierre’a Nory. Z jednej strony, napisany przez dziecko w getcie wileńskim pamiętnik ma dla pamięci kulturowej Litwy ogromne znaczenie symboliczne, etyczne i estetyczne, wzmocnione przez silne uczucie empatii wobec autora. Z drugiej strony, tekst pamiętnika stawia wysokie wymagania badawcze wynikające z konfliktu różnych interpretacji historii II wojny światowej i narracji pamięci. Socjalistyczne i proradzieckie poglądy autora, negatywny obraz Litwinów i swoista deheroizacja społeczności getta przekształca ten tekst w „problematyczne” miejce pamięci. Powyższe wyzwania badawcze są interpretowane w artykule jako znaki, które mogą opisać stan współczesnej litewskiej narracji Holocaustu i odpowiedzieć na pytanie, czy jest ona na tyle dojrzała, by w drodze dialogu zintegrować różne warianty pamięci kulturowej.
The effect of interactive computer play on balance and functional abilities in children with moderate cerebral palsy: a pilot randomized study
Authors: Pin Tamis W , Butler Penelope B 
Published: January 2019

Objectives: To investigate the feasibility and potential efficacy of a six-week interactive computer play training on balance and gross motor function in children with moderate cerebral palsy. Design: A pilot single-blinded matched randomized controlled study. Setting: Community. Participants: In total, 18 children with moderate cerebral palsy were recruited, paired according to age and severity of cerebral palsy and randomized into intervention group or control group. Intervention: The intervention group received additional trunk control training using the interactive computer play in sitting four times per week, 20 minutes per session for six weeks. All study children continued their usual physiotherapy programme. Measurements: All study children were assessed at baseline, week 3, week 6 (completion of intervention) and week 12 using the Pediatric Reach Test, Gross Motor Function Measure–66-Item Set and 2-Minute Walk Test. Results: All intervention children completed and enjoyed the training with no reported adverse event. All children were assessed at all time points. No significant difference was found between the two groups in all assessments. In both groups of children, significant improvements were found in the Gross Motor Function Measure–66-Item Set between week 3 (intervention group: mean 53.41, SD 5.34; control group: mean 52.86, SD 8.33) and week 6 (intervention group: mean 55.00, SD 6.32; control group: mean 54.20, SD 8.35). Conclusion: The intervention protocol of a six-week interactive computer play training was feasible and safe for children with moderate cerebral palsy in special school settings. Future studies with larger sample sizes or using single-subject designs are recommended.
Virtual Reality Simulation Technology for Cardiopulmonary Resuscitation Training: An Innovative Hybrid System With Haptic Feedback
Authors: Almousa Omamah , Prates Joana , Yeslam Noor , Mac Gregor Dougal , Zhang Junsong , Phan Viet , Nielsen Marc , Smith Richard , Qayumi Karim 
Published: January 2019

Objective. Although cardiopulmonary resuscitation (CPR) skills are lifesaving skills, the gap between awareness and actual training remains significant. Advances in technology are shaping the future of education and innovative learning solutions are essential to facilitate effective and accessible training. This project objective is to develop a self-directed educational system for hands-on CPR training using virtual reality (VR) technology. Methods. HTC VIVE was the chosen VR engine, and Unity3D was the software used for development. CPR skills including chest compressions, rescue breathing, and automated external defibrillator (AED) are taught in VR through focused instructions, demonstrations, and simulated interactive scenarios with hands-on training sessions. A tracking system was designed using virtual planes and VIVE-Tracker for accurate measurements of chest compressions (rate, depth, and recoil), hands’ position and AED. A real mannequin was integrated in the VR space and overlaid with virtual 3D-human model for realistic haptic feedback and hands-on training. VIVE-controller was used for precise calibration between the mannequin location in real environment and the virtual human model in VR space. Results. The VR-CPR prototype was designed to be generic, approachable, and easy to follow. Realism and interaction were achieved through 3D virtual scenes simulating common sites at which cardiac arrest may occur. Variety in scenarios and gamification features like scoring and difficulty levels of training were made to enhance users’ engagement. The VR-mannequin hybrid system enabled quality training and immersive learning experience. Further, real-time feedback and scoring system are built for self-directed learning and optimal performance. Conclusions. The developed VR-hybrid product is a structured educational tool for hands-on CPR training and ongoing practice. This innovative technology provides self-directed learning with no restrictions of time, place, or personnel, which are the main challenges with current traditional courses. This product is a promising CPR training initiative in the evolution of digital education.
M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in Asian patients with pretreated recurrent or refractory gastric cancer: Preliminary results from a phase I trial.
Authors: Kang Yoon-Koo , Doi Toshihiko , Kondo Shunsuke , Chung Hyun-Choel , Muro Kei , Helwig Christoph , Watanabe Morihiro , Bang Yung-Jue 
Published: January 2019

100 Background: Inhibiting the transforming growth factor β (TGF-β) pathway, which plays a key role in tumor immunosuppression, may enhance the response to programmed death 1/programmed death ligand 1 (PD-1/PD-L1) monoclonal antibodies (mAbs). M7824 (MSB0011359C) is an innovative first-in-class bifunctional fusion protein composed of a mAb against PD-L1 fused with the extracellular domain of TGF-β receptor II, which serves as a TGF-β “trap.” We report preliminary results in Asian patients with heavily pretreated gastric cancer. Methods: In this expansion cohort of the ongoing, phase 1, open-label trial NCT02699515, patients with recurrent or refractory unresectable stage IV gastric or gastroesophageal junction adenocarcinoma for which no standard therapy exists or standard therapy has failed receive M7824 1200 mg q2w until confirmed progressive disease, unacceptable toxicity or trial withdrawal. The primary objective is safety; secondary objectives include best overall response (BOR) per RECIST v1.1. Results: As of 6 September 2017, 31 heavily pretreated patients with advanced gastric cancer (67.7% received ≥3 prior anticancer therapies) received M7824 for a median duration of 6.1 (range: 2-30) weeks (median number of M7824 infusions: 3 [range: 1-13]); 8 patients remained on treatment. Four patients (12.9%) experienced grade 3 treatment-related adverse events (anemia and diarrhea 1 each and 2 rash). No treatment-related grade 4 AEs occurred. One grade 5 event (total 5 doses received) was considered possibly treatment related, but suspected rupture of preexisting thoracic aortic aneurysm was cited as other probable cause by the investigator. There were 5 confirmed partial responses (4 ongoing after 4-6 months of follow-up) based on investigator assessment of BOR (overall response rate: 16.1%). This is an ongoing study; updated data will be presented. Conclusions: These preliminary data show that M7824 resulted in a manageable safety profile in heavily pretreated Asian patients with gastric cancer. Early signs of clinical efficacy are encouraging. Clinical trial information: NCT02699515.
Safety and antitumor activity of ramucirumab plus pembrolizumab in treatment naïve advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: Preliminary results from a multi-disease phase I study (JVDF).
Authors: Chau Ian , Penel Nicolas , Arkenau Hendrik-Tobias , Santana-Davila Rafael , Calvo Emiliano , Soriano Andres O. , Mi Gu , Jin Jin , Ferry David , Herbst Roy S. , Fuchs Charles S. 
Published: January 2019

101 Background: Preclinical evidence suggests simultaneous blockade of vascular endothelial growth factor receptor 2 (VEGFR-2) and programed cell death 1 protein (PD-1) induces synergistic antitumor effects. We assessed safety and preliminary efficacy of ramucirumab (anti-VEGFR-2) plus pembrolizumab (anti-PD-1) in patients (pts) with treatment naïve advanced G/GEJ adenocarcinoma. Methods: This ongoing, multi-cohort, phase 1a/b trial enrolled ECOG PS 0-1 pts with treatment naïve advanced G/GEJ adenocarcinoma with measurable disease and baseline tumor tissue. PD-L1 status was assessed by DAKO PD-L1 22C3 IHC pharmDx assay using the combined positive score with ≥1% being positive. Ramucirumab was administered at 8 mg/kg on Days 1 & 8 with pembrolizumab 200 mg on Day 1 q3W. Primary objective was safety and tolerability of study treatment; preliminary efficacy was examined. Results: As of 31-July-2017, 28 treatment naïve G/GEJ adenocarcinoma pts were treated. Median age was 63 y, 75% male, 57% had ECOG PS of 0, and 68% were PD-L1 positive. At data cutoff, 8 (28%) pts continued to receive study treatment. Median duration of follow-up was 8.1 mo (IQR 6-10). Median treatment duration was 4.3 mo (IQR 2-7). All grades treatment-related adverse events (TRAEs) occurred in 27 (96%) of patients; TRAEs in ≥15% of pts were fatigue (36%), hypertension (25%) and headache (18%). Seventeen (61%) pts experience grade 3 TRAEs, most commonly hypertension (14%), diarrhea (11%), and elevated alanine (7%) or aspartate (7%) aminotransferase. No grade 4-5 TRAEs occurred. An objective response was achieved by 7 (25%) pts, 6 positive and 1 negative for PD-L1. Disease control rate was 68%. Median time to response was 2.7 mo (95% CI 1.3-2.8) and median duration of response was 10 mo (95% CI 9.7-10.3). Median progression-free survival was 5.3 mo (95% CI 3.2-11). Median overall survival has not been reached. Conclusions: Ramucirumab plus pembrolizumab demonstrated encouraging antitumor activity in treatment naïve advanced G/GEJ adenocarcinoma with no grade 4 TRAE observed. Clinical trial information: NCT02443324.