bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação da toxicidade de defensivos agrícolas usados nas lavouras de Grajaú – MA e seus efeitos ao meio ambiente
Authors: Costa Ludyane Nascimento , Tito Coimbra Afonso Henrique , Sousa Mota Guilherme 
Published: November 2024

O Brasil encontra-se hoje como um dos maiores consumidores de agrotóxicos do mundo devido à vasta expansão da agricultura. Nesse contexto, o estado do Maranhão se destaca como um grande produtor agrícola, tendo sua economia calcada no cultivo de lavouras de soja, arroz, cana-de-açúcar e outras leguminosas. O trabalho em questão identificou de forma qualitativa e quantitativa os principais ingredientes ativos utilizados nas lavouras com produção mais significativa na cidade de Grajaú-MA, escolhida pelo destaque nas plantações citadas e também pela localização geográfica. A coleta de dados realizada teve o intuito de identificar os principais agrotóxicos utilizados, os efeitos que os mesmos podem provocar ao meio ambiente e à saúde do ser humano, bem como as formas de utilização desses, considerando o uso adequado de EPIs e os limites estabelecidos para aplicação. As lavouras estudadas mostraram um controle adequado no uso de pesticidas e herbicidas na produção agrícola, respeitando os limites estabelecidos por lei. Entretanto, utilizam produtos com alta grau de toxicidade e de difícil degradação, podendo gerar consequências ao meio ambiente. É importante frisar que dados como esses ainda são bem escassos no estado do Maranhão, daí a importância da coleta de informações sobre o setor agrícola e o uso de defensivos químicos, bem como propostas alternativas viáveis e mais seguras.
Theory to Practice: An Assessment Framework for Generative AI.
Authors: Page Eric , Meyers Gretchen , Billings Eve 
Published: November 2024

Recent advancements in generative artificial intelligence (AI) have disrupted assessment practices within the higher education sector. The efficacy of existing assessment approaches is under reexamination with the introduction of generative AI’s ability to generate human-like text. Simultaneously, there are calls to integrate generative AI into assessment design to enhance learning and prepare students for a new era of technology in their careers. This paper proposes a framework to integrate generative AI into formative and summative assessments across Bloom’s levels and Knowledge Dimensions. Its purpose is to illustrate the versatility and intricacy of generative AI’s potential applications grounded in existing learning theory while retaining a focus on authentic assessment. The goal is to support higher education professionals stimulate assessment design concepts featuring generative AI positioned within varying learning complexities.
Saberes compartidos y procesos participativos de diseño en el Chaco Occidental. Salta, Argentina
Authors: Trillo Joaquín , Agudin Catalina Lucía , Pasin Malena , Ceciaga Mercedes 
Published: November 2024

La transferencia de tecnologías promovidas por los programas para el desarrollo, no suele contemplar las soluciones de forma y función con que las comunidades wichi del Gran Chaco dan significado a sus arquitecturas. Contenidos y diseños promovidos desde una gestión centralizada de las decisiones, son implementados por agencias capaces de influir en políticas que desconsideran las condiciones del lugar y las trayectorias de los pueblos sobre los que actúan. Al examinar las apropiaciones y resignificaciones desplegadas por las poblaciones locales sobre estas intervenciones, repasaremos distintos lineamientos teóricos que desde el pensamiento crítico latinoamericano proponen la necesidad de cuestionar los principios de la modernidad global hacia alternativas en donde el punto de origen se encuentre en los saberes subalternos. En este marco, el trabajo explora las lógicas de la construcción social del hábitat mediante procesos participativos de diseño que permiten elevar a las comunidades de destinatarias a creadoras de sus propias decisiones.
Caries dental: Prevención y tratamiento desde un enfoque multidisciplinario [Dental caries: Prevention and treatment from a multidisciplinary approach]
Authors: Haon-Moscoso Damaris Meylin , Cevallos-Romero Fernanda Romina , Macías-Molina Betzaida Estefanía , Villacrés-Yancha Delia María 
Published: November 2024

Objetivo: analizar la caries dental desde una perspectiva multidisciplinaria de prevención y tratamiento. Método: se aplicó revisión sistemática, la población se refinó a 15 articulos científicos. Resultados: la suplementación prenatal podría tener un rol preventivo en la salud bucal infantil. Conclusión: el uso de modelos de evaluación de riesgo, la aplicación de tratamientos mínimamente invasivos y el control de la biopelícula permiten reducir la progresión de las lesiones cariosas y mejorar la salud bucal a lo largo del tiempo.
Comentários ao Acórdão nº 0061204-79.2019.8.19.0000 do Tribunal de Justiça do Estado do Rio de Janeiro, julgado em 24 de março de 2022
Authors: DIOGO DOS SANTOS BAPTISTA  , JOSÉ MARCOS VIEIRA RODRIGUES FILHO  , GUILHERME MOULIN SIMÕES PENALVA SANTOS  , GUSTAVO PINHA DE ABREU  , LUIZA VEREZA BATISTA KALAOUN  , MARCELO SILVA MOREIRA MARQUES  , MARCO ANTONIO FERREIRA MACEDO  , MARINA ARANTES DE MATTOS  , PAULO MAURÍCIO FERNANDES DA ROCHA  , PRISCILA MARIA DANZIGER SCHECHTER  , THIERRY MOUGENOT BONFIM FERREIRA DOS REIS  , KAREN FERNANDES SARAIVA  , CHRISTIANE DE ALMEIDA FERREIRA  
Published: November 2024

INCIDENTE DE RESOLUÇÃO DE DEMANDAS REPETITIVAS EM APELAÇÃO CÍVEL. OBRIGAÇÃO DE FAZER E COMPENSAÇÃO A TÍTULO DE DANOS MORAIS. TRANSBORDAMENTO DE ESGOTO. LOCALIDADE DO CANAL DO ANIL. As discussões referem-se a pretensão de compensação e de pretensa ordem para desobstrução de rede de esgotamento sanitário. A questão, todavia, não se refere a mera desobstrução de rede. O local, situado abaixo da linha d’água, é área sujeita a alagamento em razão do relevo. No local foi edificada rede pelos moradores, que se sobrepõe a antiga rede da Cedae, posteriormente assumida pelo Município. Na origem, a rede foi instalada para atender localidade cuja densidade demográfica foi integralmente alterada, sendo desfigurada a rede pela intervenção de moradores. Os transbordamentos não decorrem de simples obstrução na rede, mas de insuficiência da mesma e da ausência de galeria de águas pluviais no local. A questão, assim, diz respeito a necessidade de revitalização da rede e incremento de medidas de urbanização. Em concorrência internacional aberta, foi apontada a necessidade de plano de estruturação do sistema, a ser cumprido a longo prazo. Desta maneira, a questão em discussão refere-se a implemento de políticas públicas no local, não cabendo ao Judiciário, à guisa de sanar questões individuais, impor cumprimento de obrigação que depende de revitalização de toda a área. Impossibilidade de interferência do Judiciário. Inexistência de inadimplemento ou de omissão dos entes públicos ou dos órgãos da Administração. Questão afeta às políticas públicas. Novo marco de saneamento. Concorrência Internacional. Inserção da Comunidade do Anil no Bloco 2. Controle da implementação que deve se dar através do acompanhamento do cumprimento da nova concessão. FIXA-SE, ENTÃO, PARA OS FINS DO ART. 985 DO CPC, A SEGUINTE TESE: Na localidade "Canal do Anil" a pretensão de haver a desobstrução da rede de esgoto local, compensação por danos morais pelos transbordamentos, multa e convolação em obrigação de fazer refere-se a políticas públicas, não cabendo ao Judiciário intervir em sua implementação. Caso piloto: Provimento das apelações, julgando-se improcedentes os pedidos autorais, com a reversão da sucumbência.
DESENVOLVIMENTO DE BARRA DE CEREAL FUNCIONAL COM FRUTOS REGIONAIS PARA PACIENTES CELÍACOS E ALÉRGICOS AO LEITE DE VACA
Authors:   Francisca Marta Nascimento de Oliveira Freitas, Santos Igor Beijamim Freitas Dos , Batista Katriny Isabella Lopes , Pinto Nataly Gonçalves ,   Ana Rita Gaia Machado
Published: November 2024

O objetivo dessa pesquisa é descrever a elaboração de uma barra de cereal nutricional para atender pessoas diagnosticadas com doença celíaca e alergia ao leite de vaca, e que possuem como medidas as dietas restritivas. A sua construção foi dada em laboratório de gastronomia, observando uma posterior análise físico-química que transmite valores de altos níveis de fibras e proteínas, fundamentais para a saúde digestiva e essenciais para o alimento ser considerado funcional. Os resultados das análises microbiológicas constataram a ausência de contaminação por coliformes e patógenos. Além disso, o custo total de produção foi estimado em R$ 22,26, sendo a castanha do Brasil e o cupuaçu os ingredientes de maior impacto no valor. Por tanto, o trabalho desenvolvido é relevante para. Como resultados, o trabalho contribui com o avanço de pesquisas que desenvolvem esta classe de alimentos utilizando matéria-prima regional, o que atende a uma demanda cada vez mais crescente de consumidores com restrições dietéticas. Por fim, conclui-se que a barra de cereal possui características adequadas na promoção da saúde e se destaca como uma alternativa de consumo para pessoas diagnosticadas com as doenças supramencionadas.
Recent Advances on Polymer Lipid Particles (
PoLP
) in Membrane Protein Research
Authors: de Marcos Lousa Carine , Postis Vincent 
Published: July 2018

Abstract

Membrane proteins (MPs) structure elucidation is of crucial importance as they represent a major target for drug design. However, owing to their high hydrophobicity, MPs are challenging proteins to study. The use of polymer lipid nanoparticles (PoLP) has recently allowed a leap forward in the field of MP research. A wide range of polymers have been successfully used for elucidating the structure of MPs. One polymer in particular, styrene maleic acid (SMA) copolymer, is recently catching a large interest owing to its easy use in detergent‐free membrane solubilisation and the recent successes in purification and stabilising MPs for further biophysical studies.

Key Concepts

SMA copolymers are new tools to purify membrane proteins.

SMA copolymers can solubilise membrane proteins directly without the need of detergents.

Membrane proteins purified in SMALP are stable over time and remain active owing to the retention of native lipids around the proteins.

SMA use limitations include acid pH sensitivity, divalent cations sensitivity and UV absorption.

New polymers (SMA and others) are being engineered to overcome these limitations.
Corporate Strategy
Authors: Brønn Carl , Brønn Peggy Simcic 
Published: July 2018

Abstract
Strategy is a multipurpose concept with many applications. As a noun, it is a field of study and practice concerned with the overall performance of systems, usually human activity systems. As an adjective, it typically modifies nouns denoting common business functions that are generally understood as operational, where adding the word “strategic” has the effect of highlighting their contributions to the long‐term viability of the firm. Strategy implies a high‐level perspective, broader scope, or greater responsibility that contrasts with the tactical or operational levels of the organization. In general, the focus of strategy is on the organization's long‐term direction. This involves defining the scope of its activities, and building and maintaining the resources and capabilities required to support its objectives. A strategy should address how to gain and sustain advantage over competitors in a dynamic and changing business environment.
Electric‐Field‐Assisted Single‐Step In Situ Fabrication and Focal Length Control of Polymeric Convex Lens on Flexible Substrate
Authors: Kim Jonghyun , Shin Dongwoon , Mahmood Tawsif , Chang Jiyoung 
Published: July 2018

AbstractHere, a simple method for fabricating polymeric convex lens and controlling of its focal length in a single‐step fabrication is presented. The method utilizes electrostatic force to pull the polymer droplet to form the lens, as well as to accelerate the droplet to control the curvature of the lens simultaneously. Lenses with various diameter (ranging from 0.75 to 4.5 mm) and curvature are sequentially fabricated at the preprogrammed position on a dielectric and flexible substrate. Since a transparent dielectric flexible film is employed as a target substrate, not only the electrical short circuit in the process is prevented but also high optical transmittance is secured with superior mechanical bendability which allows transformation of the lens into a positive single‐axis meniscus. To show the functionality, the lenses are integrated into a microscope for a teleconverter, fluidic tubing for a magnifier, laser exposing for a concentrator, and LED bulb encapsulating as a light diffuser. The presented method with extremely simple fabrication step with focal length control is expected to be directly applied to a wide range of applications.
All‐Dielectric Metalattice with Enhanced Toroidal Dipole Response
Authors: Sayanskiy Andrey , Danaeifar Mohammad , Kapitanova Polina , Miroshnichenko Andrey E. 
Published: July 2018

AbstractA novel type of all‐dielectric metalattice is proposed and experimentally demonstrated, which supports broadband dominant toroidal dipole response. The unit cell consists of four rectangular bars made of dielectric materials of moderate contrast. By performing multipole decomposition it is found that toroidal dipole response is dominant over a wide frequency range. The correlation between the toroidal dipole response and longitudinal electric field component is also shown. By using this feature, as well as direct near‐field mapping, the broadband toroidal dipole response of such metalattice is experimentally verified. Since the unit cell exhibits C4 rotational symmetry this response is shown to be polarization independent.
Targeting the Achilles Heel of Zika Virus and Other Emerging Viral Pathogens
Authors: Jackman Joshua A. , Cho Nam‐Joon 
Published: July 2018

AbstractViruses are a leading cause of infectious diseases and represent one of the world's biggest global health problems. The continual appearance of new and reemerging viruses exceeds our capacity to provide effective medical solutions, as highlighted by the recent Zika epidemic. Herein, the authors discuss how unconventional approaches might lead to innovations in antiviral drug development that would address this outstanding need. In particular, the case of Zika virus is analyzed and the authors suggest that a materials science and engineering perspective might revolutionize antiviral drug development. Zika virus and related viruses possess a lipid membrane envelope that is an Achilles heel because it is necessary for viral function and there is a high barrier for mutations to evolve there. The development of antiviral drugs, such as certain membrane‐active peptides, to selectively target the lipid membrane envelope would represent an entirely new therapeutic approach. Such efforts could be aided by engineering approaches to design and characterize promising drug candidates that work against multiple viruses. Looking forward, there is excellent potential to develop new therapeutic strategies that target the Achilles heel of Zika virus and other emerging viral pathogens.
A Lithium–Sulfur Cell Based on Reversible Lithium Deposition from a Li2S Cathode Host onto a Hostless‐Anode Substrate
Authors: Nanda Sanjay , Gupta Abhay , Manthiram Arumugam 
Published: July 2018

AbstractThe development of lithium–sulfur batteries necessitates a thorough understanding of the lithium‐deposition process. A novel full‐cell configuration comprising an Li2S cathode and a bare copper foil on the anode side is presented here. The absence of excess lithium allows for the realization of a truly lithium‐limited Li–S battery, which operates by reversible plating and stripping of lithium on the hostless‐anode substrate (copper foil). Its performance is closely tied to the efficiency of lithium deposition, generating valuable insights on the role and dynamic behavior of lithium anode. The Li2S full cell shows reasonable capacity retention with a Coulombic efficiency of 96% over 100 cycles, which is a tremendous improvement over that of a similar lithium‐plating‐based full cell with LiFePO4 cathodes. The exceptional robustness of the Li2S system is attributed to an intrinsic stabilization of the lithium‐deposition process, which is mediated by polysulfide intermediates that form protective Li2S and Li2S2 regions on the deposited lithium. Combined with the large improvements in energy density and safety by the elimination of a metallic lithium anode, the stability and electrochemical performance of the lithium‐plating‐based Li2S full cell establish it as an important trajectory for Li–S battery research, focusing on practical realization of reversible lithium anodes.
Impact of emergency physicians competent in severe trauma management, surgical techniques, and interventional radiology on trauma management
Authors: Otsuka Hiroyuki , Sato Toshiki , Sakurai Keiji , Aoki Hiromichi , Yamagiwa Takeshi , Iizuka Shinichi , Inokuchi Sadaki 
Published: July 2018

AimDespite recent advancements in trauma management following introduction of interventional radiology (IVR) and damage‐control strategies, challenges remain regarding optimal use of resources for severe trauma.MethodsIn October 2014, we implemented a trauma management system comprising emergency physicians competent in severe trauma management, surgical techniques, and IVR. To evaluate this system, of 5,899 trauma patients admitted to our hospital from January 2011 to January 2018, we selected 107 patients with severe trauma (injury severity score ≥ 16) who presented with persistent hypotension (two or more systolic blood pressure measurements <90 mmHg), regardless of primary resuscitation. Patients were divided according to the date of admission: Conventional (January 2011–September 2014) or Current (October 2014–January 2018). The primary end‐point was in‐hospital mortality. Secondary end‐points included time from arrival to start of surgery/IVR.ResultsThere were 59 patients in the Conventional group and 48 in the Current group. Although patients in the Current group were more severely ill compared with those in the Conventional group, mortality in the Current group was significantly lower (Conventional 64.4% versus Current 41.7%, P = 0.019), especially among patients whose first intervention was IVR (Conventional 75.0% versus Current 28.6%, P = 0.001). Time from arrival to initiation of surgery/IVR was shorter in the Current group (Conventional 71.5 [53.8–130.8] min versus Current 41.0 [26.0–58.5] min, P < 0.0001).ConclusionsThis trauma management system based on emergency physicians competent not only in severe trauma management, but also surgical techniques and IVR, could improve outcomes in patients with severe multiple lethal trauma.
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome
Authors: Shin Min Sun , Kang Youna , Wahl Elizabeth R. , Park Hong‐Jai , Lazova Rossitza , Leng Lin , Mamula Mark , Krishnaswamy Smita , Bucala Richard , Kang Insoo 
Published: July 2018

ObjectiveHigh‐expression alleles of macrophage migration inhibitory factor (MIF) are linked genetically to the severity of systemic lupus erythematosus (SLE). The U1 small nuclear RNP (snRNP) immune complex containing U1 snRNP and anti–U1 snRNP antibodies, which are found in patients with SLE, activates the NLRP3 inflammasome, comprising NLRP3, ASC, and procaspase 1, in human monocytes, leading to the production of interleukin‐1β (IL‐1β). This study was undertaken to investigate the role of the snRNP immune complex in up‐regulating the expression of MIF and its interface with the NLRP3 inflammasome.MethodsMIF, IL‐1β, NLRP3, caspase 1, ASC, and MIF receptors were analyzed by enzyme‐linked immunosorbent assay, Western blotting, quantitative polymerase chain reaction, and cytometry by time‐of‐flight mass spectrometry (CytoF) in human monocytes incubated with or without the snRNP immune complex. MIF pathway responses were probed with the novel small molecule antagonist MIF098.ResultsThe snRNP immune complex induced the production of MIF and IL‐1β from human monocytes. High‐dimensional, single‐cell CytoF analysis established that MIF regulates activation of the NLRP3 inflammasome, including findings of a quantitative relationship between MIF and its receptors and IL‐1β levels in the monocytes. MIF098, which blocks MIF binding to its cognate receptor, suppressed the production of IL‐1β, the up‐regulation of NLRP3, which is a rate‐limiting step in NLRP3 inflammasome activation, and the activation of caspase 1 in snRNP immune complex–stimulated human monocytes.ConclusionThe U1 snRNP immune complex is a specific stimulus of MIF production in human monocytes, with MIF having an upstream role in defining the inflammatory characteristics of activated monocytes by regulating NLRP3 inflammasome activation and downstream IL‐1β production. These findings provide mechanistic insight and a therapeutic rationale for targeting MIF in subgroups of lupus patients, such as those classified as high genotypic MIF expressers or those with anti‐snRNP antibodies.
Assembled Nanocomplex for Improving Photodynamic Therapy through Intraparticle Fluorescence Resonance Energy Transfer
Authors: Cao Hongqian , Qi Yanfei , Yang Yang , Wang Lei , Sun Jiaheng , Li Yue , Xia Jiarui , Wang Hao , Li Junbai 
Published: July 2018

AbstractIn recent years, one of main obstacles in a photodynamic therapy (PDT) process has been that most photosensitizers for PDT are excited by visible light with limited penetrating ability; thus most applications of PDT are for superficial treatments. One of the methods to increase the treatment depth is to introduce a two‐photon‐active technique into PDT, known as TP‐PDT. The difficulty here is to obtain photosensitizers with a large enough two‐photon absorption cross‐section. In this work, an organic nanocomplex, composed of the two‐photon nanoaggregate as the core and photosensitizer as the shell, has been constructed. Photosensitizers could be excited indirectly through a fluorescence resonance energy transfer (FRET) mechanism after the two‐photon core was excited by a two‐photon laser. The FRET efficiency was extremely high, owing to sufficient energy donors and stable energy acceptors. In this way, a photosensitizer could induce two‐photon toxicity for improving the treatment depth in PDT. The nanocomplexes were prepared through a molecular assembly method, which avoided complicated reactions for synthesizing two‐photon photosensitizers. The assembly method would expand the selection of photosensitizers and two‐photon dyes, and endow traditional photosensitizers with a larger two‐photon absorption cross‐section for TP‐PDT.