bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stratigraphic and lithofacies control on pore characteristics of Mississippian limestone and chert reservoirs of north-central Oklahoma
Authors: Suriamin Fnu , Pranter Matthew J. 
Published: July 2018

We have determined how stratigraphy and lithofacies control pore structures in the Mississippian limestone and chert reservoir of north-central Oklahoma. There are 17 lithofacies and 29 high-frequency cycles documented in the Mississippian interval of this study. The high-frequency cycles have thicknesses ranging from 0.3 to 30.5 m (1–100 ft) and are mainly asymmetric regressive phases. The pore characteristics, measured through digital-image analysis (DIA) of thin-sections photomicrographs ([Formula: see text]100), exhibit unique correlations with core porosity, permeability, and lithofacies within a sequence-stratigraphic framework. There are five fundamental correlations observed. First, porosity from DIA and laboratory core measurements has a strong positive relationship ([Formula: see text]). However, some values from DIA porosity yield relatively higher values, specifically in spiculitic mudstone wackestones and argillaceous spiculitic mudstone wackestones. The difference is hypothesized due to the presence of isolated nanopores that are not accessible by helium during measurement of core porosity. Second, the relationship between pore circularity and permeability is indeterminate. The indeterminate relationship is related to a complex internal pore network, intensive diagenetic alteration, an unconnected microfracture network, and isolated pores. Third, positive moderate to strong correlations ([Formula: see text]) between porosity and permeability are observed only in four lithofacies. Fourth, coarse-grained lithofacies within the uppermost depositional sequence of the Mississippian interval have a heterogeneous pore-size distribution, whereas fine-grained lithofacies tend to exhibit a homogeneous pore-size distribution. Fifth, higher reservoir quality is associated with the upper intervals of high-frequency shallowing-upward cycles. This confirms that the sequence-stratigraphic variability of lithofacies is important to predict reservoir quality and its distribution. An alternative graphical method of pore-size distribution is also developed. To be a useful “technique,” examples of the plot are demonstrated using samples in this study. The plot successfully provides simple identification of pore-size classes, quantitative percentage of pore-size class, dominant pore class, and approximate minimum and maximum pore size.
Clinicopathologic Features of Non–Small-Cell Lung Cancer Harboring an NTRK Gene Fusion
Authors: Farago Anna F. , Taylor Martin S. , Doebele Robert C. , Zhu Viola W. , Kummar Shivaani , Spira Alexander I. , Boyle Theresa A. , Haura Eric B. , Arcila Maria E. , Benayed Ryma , Aisner Dara L. , Horick Nora K. , Lennerz Jochen K. , Le Long P. , Iafrate A. John , Ou Sai-Hong I. , Shaw Alice T. , Mino-Kenudson Mari , Drilon Alexander 
Published: July 2018

Purpose Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. These fusions are rare in non–small-cell lung cancer (NSCLC), with frequency previously estimated to be < 1%. Inhibition of TRK signaling has led to dramatic responses across tumor types with NTRK fusions. Despite the potential benefit of identifying these fusions, the clinicopathologic features of NTRK fusion-positive NSCLCs are not well characterized. Methods We compiled a database of patients with NSCLCs that harbor NTRK fusions. We characterized clinical, molecular, and histologic features with central review of histology. Results We identified 11 patients with NSCLCs that harbor NTRK gene fusions verified by next-generation sequencing and with available clinical and pathologic data. Fusions involved NTRK1 (n = 7) and NTRK3 (n = 4), with five and two distinct fusion partners, respectively. Fifty-five percent of cohort patients were male with a median age at diagnosis of 47.6 years (range, 25.3 to 86.0 years) and a median smoking history of 0 pack-years (range, 0 to 58 pack-years). Seventy-three percent of patients had metastatic disease at diagnosis. No concurrent alterations in KRAS, EGFR, ALK, ROS1, or other known oncogenic drivers were identified. Nine patients had adenocarcinoma, including two with invasive mucinous adenocarcinoma and one with adenocarcinoma with neuroendocrine features; one had squamous cell carcinoma; and one had neuroendocrine carcinoma. By collating data on 4,872 consecutively screened, unique patients with NSCLC, we estimate a frequency of NTRK fusions in NSCLC of 0.23% (95% CI, 0.11% to 0.40%). Conclusion NTRK fusions occur in NSCLCs across sexes, ages, smoking histories, and histologies. Given the potent clinical activity of TRK inhibitors, we advocate that all NSCLCs be screened for NTRK fusions by using a multiplexed next-generation sequencing–based fusion assay.
Minimum Alveolar Concentration-Awake of Sevoflurane Is Decreased in Patients With End-Stage Renal Disease
Authors: Wu Yun , Jin Shiyun , Zhang Lei , Cheng Jie , Hu Xianwen , Chen Hong , Zhang Ye 
Published: July 2018

BACKGROUND:
End-stage renal disease (ESRD) has been shown to be associated with abnormal neural function. Clinically used inhaled anesthetic agents typically exert their effect through multiple target receptors in the central nervous system. Pathological changes in the brain may alter sensitivity to inhaled anesthetic agents. This study aimed to determine the minimum alveolar concentration-awake (MACawake) of sevoflurane in patients with ESRD compared to patients with normal renal function.

METHODS:
Patients underwent inhalational induction of anesthesia and received sevoflurane at a preselected concentration according to a modified Dixon “up-and-down” method starting at 1.0% with a step size of 0.2%. The concentration of sevoflurane used for each consecutive patient was increased or decreased based on a positive or negative response to verbal command in the previous patient. Serum neuron-specific enolase, a biomarker of impaired neurons, was also measured.

RESULTS:
Forty-one patients were enrolled: 20 with ESRD and 21 as controls. The MACawake of sevoflurane in patients with ESRD was significantly lower than that observed in the control group (0.56% [standard deviation {SD} = 0.10%] vs 0.67% [SD = 0.08%]; P = .031). Patients with ESRD exhibited higher serum neuron-specific enolase levels compared to the control group (16.4 ng/mL [SD = 5.0] vs 8.7 ng/mL [SD = 2.9]; P < .001).

CONCLUSIONS:
MACawake of sevoflurane is somewhat lower in patients with ESRD compared to those with normal renal function. Impaired cerebral function may partly contribute to the reduction in anesthetic requirement.
A Thousand Invisible Architects: Vassals, the Petition and Response System, and the Creation of Spanish Imperial Caste Legislation
Authors: Masters Adrian 
Published: July 2018

Abstract
This article explains two unique aspects of the New World Spanish empire: its production of hundreds of thousands of royal decrees, and the unique categories that these edicts contained, such as mestizo and mulato. I outline the petition and response system, through which vassals of all social backgrounds constantly suggested new laws to the ruling Council of the Indies. Pressed for time, the council's overwhelmed ministers often transplanted petitions' vocabulary verbatim into decrees. This meant that subjects often phrased imperial laws minor and major, regional and Indies-wide. Using a four-step archival methodology, this article demonstrates how scholars can match vassals' petitions to decrees. This essay then shows how legal categories such as mestizo and mulato came about through the petitions of not only Spaniards but also Indians, mestizos, and mulatos themselves. Subjects of any social background could therefore introduce and shape Indies legal constructs, and the empire's agenda, from the ground up.
Location and functions of Inebriated in theDrosophilaeye
Authors: Borycz Janusz , Ziegler Anna , Borycz Jolanta A. , Uhlenbrock Guido , Tapken Daniel , Caceres Lucia , Hollmann Michael , Hovemann Bernhard T. , Meinertzhagen Ian A. 
Published: July 2018

ABSTRACTHistamine (HA) is a neurotransmitter in arthropod photoreceptors. It is recycled via conjugation to β-alanine to form β-alanylhistamine (carcinine). Conjugation occurs in epithelial glia that surround photoreceptor terminals in the first optic neuropil, and carcinine (CA) is then transported back to photoreceptors and cleaved to liberate HA and β-alanine. The gene Inebriated (Ine) encodes an Na+/Cl−-dependent SLC6 family transporter translated as two protein isoforms, long (P1) and short (P2). Photoreceptors specifically express Ine-P2 whereas Ine-P1 is expressed in non-neuronal cells. Both ine1 and ine3 have significantly reduced head HA contents compared with wild type, and a smaller increase in head HA after drinking 1% CA. Similarly, uptake of 0.1% CA was reduced in ine1 and ine3 mutant synaptosomes, but increased by 90% and 84% respectively for fractions incubated in 0.05% β-Ala, compared with wild type. Screening potential substrates in Ine expressing Xenopus oocytes revealed very little response to carcinine and β-Ala but increased conductance with glycine. Both ine1 and ine3 mutant responses in light-dark phototaxis did not differ from wild-type. Collectively our results suggest that Inebriated functions in an adjunct role as a transporter to the previously reported carcinine transporter CarT.
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
Authors: Mavor David , Barlow Kyle A. , Asarnow Daniel , Birman Yuliya , Britain Derek , Chen Weilin , Green Evan M. , Kenner Lillian R. , Mensa Bruk , Morinishi Leanna S. , Nelson Charlotte A. , Poss Erin M. , Suresh Pooja , Tian Ruilin , Arhar Taylor , Ary Beatrice E. , Bauer David P. , Bergman Ian D. , Brunetti Rachel M. , Chio Cynthia M. , Dai Shizhong A. , Dickinson Miles S. , Elledge Susanna K. , Helsell Cole V. M. , Hendel Nathan L. , Kang Emily , Kern Nadja , Khoroshkin Matvei S. , Kirkemo Lisa L. , Lewis Greyson R. , Lou Kevin , Marin Wesley M. , Maxwell Alison M. , McTigue Peter F. , Myers-Turnbull Douglas , Nagy Tamas L. , Natale Andrew M. , Oltion Keely , Pourmal Sergei , Reder Gabriel K. , Rettko Nicholas J. , Rohweder Peter J. , Schwarz Daniel M. C , Tan Sophia K. , Thomas Paul V. , Tibble Ryan W. , Town Jason P. , Tsai Mary K. , Ugur Fatima S. , Wassarman Douglas R. , Wolff Alexander M. , Wu Taia S. , Bogdanoff Derek , Li Jennifer , Thorn Kurt S. , O'Conchúir Shane , Swaney Danielle L. , Chow Eric D. , Madhani Hiten D. , Redding Sy , Bolon Daniel N. , Kortemme Tanja , DeRisi Joseph L. , Kampmann Martin , Fraser James S. 
Published: July 2018

ABSTRACT
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the difference between fitness under laboratory culture conditions and the selective pressures in changing environments over evolutionary timescales. Building on our previous work (Mavor et al., 2016), we used deep mutational scanning to determine how twelve new chemicals (3-Amino-1,2,4-triazole, 5-fluorocytosine, Amphotericin B, CaCl2, Cerulenin, Cobalt Acetate, Menadione, Nickel Chloride, p-Fluorophenylalanine, Rapamycin, Tamoxifen, and Tunicamycin) reveal novel mutational sensitivities of ubiquitin residues. Collectively, our experiments have identified eight new sensitizing conditions for Lys63 and uncovered a sensitizing condition for every position in Ub except Ser57 and Gln62. By determining the ubiquitin fitness landscape under different chemical constraints, our work helps to resolve the inconsistencies between deep mutational scanning experiments and sequence conservation over evolutionary timescales.
The importance of incorporating natural thermal variation when evaluating physiological performance in wild species
Authors: Morash Andrea J. , Neufeld Claire , MacCormack Tyson J. , Currie Suzanne 
Published: July 2018

ABSTRACTEnvironmental variability in aquatic ecosystems makes the study of ectotherms complex and challenging. Physiologists have historically overcome this hurdle in the laboratory by using ‘average’ conditions, representative of the natural environment for any given animal. Temperature, in particular, has widespread impact on the physiology of animals, and it is becoming increasingly important to understand these effects as we face future climate challenges. The majority of research to date has focused on the expected global average increase in temperature; however, increases in climate variability are predicted to affect animals as much or more than climate warming. Physiological responses associated with the acclimation to a new stable temperature are distinct from those in thermally variable environments. Our goal is to highlight these physiological differences as they relate to both thermal acclimation and the ‘fallacy of the average’ or Jensen's inequality using theoretical models and novel empirical data. We encourage the use of more realistic thermal environments in experimental design to advance our understanding of these physiological responses such that we can better predict how aquatic animals will respond to future changes in our climate.
Missing the point: are journals using the ideal number of decimal places?
Authors: Barnett Adrian G 
Published: July 2018

Background:The scientific literature is growing in volume and reducing in readability. Poorly presented numbers decrease readability by either fatiguing the reader with too many decimal places, or confusing the reader by not using enough decimal places, and so making it difficult to comprehend differences between numbers. There are guidelines for the ideal number of decimal places, and in this paper I examine how often percents meet these guidelines.Methods:Percents were extracted from the abstracts of research articles published in 2017 in 23 selected journals. Percents were excluded if they referred to a statistical interval, typically a 95% confidence interval. Counts and percents were calculated for the number of percents using too few or too many decimal places, and these percents were compared between journals.Results:The sample had over 43,000 percents from around 9,500 abstracts. Only 55% of the percents were presented according to the guidelines. The most common issue was using too many decimal places (33%), rather than too few (12%). There was a wide variation in presentation between journals, with the range of ideal presentation from a low of 53% (JAMA) to a high of 80% (Lancet Planetary Health). Conclusions:Many percents did not adhere to the guidelines on using decimal places. Using the recommended number of decimal places would make papers easier to read and reduce the burden on readers, and potentially improve comprehension. It should be possible to provide automated feedback to authors on which numbers could be better presented.
An international, Delphi consensus study to identify priorities for methodological research in behavioural trials: A study protocol
Authors: Byrne Molly , McSharry Jenny , Meade Oonagh , Lavoie Kim L. , Bacon Simon L. 
Published: July 2018

Background: Effective behaviour change interventions are needed to impact important health outcomes, including morbidity and mortality. However, the uptake and impact of behavioural interventions have been limited by methodological challenges. The International Behavioural Trials Network (IBTN) was established in 2013 to facilitate global improvement in methodological quality of behavioural trials. There has been no formal process, within the network or in the broader literature, to define the most important research priorities to achieve this aim. In this project, we will conduct an international, Delphi consensus study to identify and achieve consensus on priorities for methodological research in behavioural trials among IBTN members. Methods: Fifteen core members of IBTN, who are experts in the field of behavioural intervention research, will be invited to generate a list of all items they consider priority areas for methodological research in trials of behavioural interventions. The IBTN Research Prioritisation team (the authors) will review all items generated, removing duplicates and merging similar topics, and generate a ‘long-list’ of items. This long-list will be sent to the 15 IBTN core members for approval. We will then administer two online Delphi surveys to all IBTN members. In the first survey, respondents will be asked to rate the importance of each item on a nine-point scale and rank their top five priorities. In the second survey, respondents will receive feedback on others’ responses and a reminder of their own responses in survey 1, and will be asked to re-rate items and re-select their ‘top five’. Discussion: Findings from the project will be used to inform the research agenda of the IBTN and to make recommendations for future research.
Understanding the cultural meanings of stroke in the Ghanaian setting: A qualitative study exploring the perspectives of local community residents
Authors: Sanuade Olutobi 
Published: July 2018

Background: Stroke has undergone different medical constructions over the years. While the medical profession posits that disease is a biological condition, universal and unchanging, social constructionists perceive illness as the social meaning of the biological condition. Even though the medical notion of stroke is monolithic and sometimes contradicts the representations by local community residents, little attention has been paid to understanding the cultural meanings of stroke. This study explores the cultural meanings of stroke in five different cultural settings in Ghana. Methods: 30 focus group discussions (FGDs) were conducted with local community members in five communities (Ga Mashie, Tafo, Gyegyeano, Chanshegu and Agorve) located in five regions in Ghana. The FGDs were conducted in Ga, Twi, Fante, Ewe and Dagbani, and were transcribed verbatim into English. The transcripts were analysed thematically. Results: The local words used for stroke in all the five cultural settings focused on physical disability associated with stroke after its onset, and this formed the dominant source of fear about the condition. Participants mentioned that spiritual and left-side stroke have the most debilitating impact on the sufferer. Although there was a general consensus that anyone can be at risk of stroke, there was a gender dynamics in the explanation of risk relativity. Participants believed that stroke can be cured through early detection and treatment, use of herbal medicines, and availability of financial resources. Compared to other disabling conditions, the community residents perceived stroke to be more severe due to its multifaceted disabilities. Conclusions: This study showed that the social meanings of stroke in the five communities are multifaceted, and reflected co-existence of biomedical and cultural frameworks. The findings showed the need to pay good attention to the sociocultural context when developing interventions strategies on stroke prevention and control.
On-Demand Service Platforms
Authors: Taylor Terry A. 
Published: July 2018

An on-demand service platform connects waiting-time-sensitive customers with independent service providers (agents). This paper examines how two defining features of an on-demand service platform—delay sensitivity and agent independence—impact the platform’s optimal per-service price and wage. Delay sensitivity reduces expected utility for customers and agents, which suggests that the platform should respond by decreasing the price (to encourage participation of customers) and increasing the wage (to encourage participation of agents). These intuitive price and wage prescriptions are valid in a benchmark setting without uncertainty in the customers’ valuation or the agents’ opportunity costs. However, uncertainty in either dimension can reverse the prescriptions: Delay sensitivity increases the optimal price when customer valuation uncertainty is moderate. Delay sensitivity decreases the optimal wage when agent opportunity cost uncertainty is high and expected opportunity cost is moderate. Under agent opportunity cost uncertainty, agent independence decreases the price. Under customer valuation uncertainty, agent independence increases the price if and only if valuation uncertainty is sufficiently high. The online appendix is available at https://doi.org/10.1287/msom.2017.0678 .
Sob o signo da complexidade: trocas interculturais entre França e Brasil
Authors: De Luca Tania Regina 
Published: July 2018

Resenha: FLÉCHET, Anaïs; COMPAGNON, Olivier; ALMEIDA, Silvia Capanema P. de. Como era fabuloso o meu francês! Imagens e imaginários da França no Brasil (séculos XIX-XXI). Rio de Janeiro: Fundação Casa de Rui Barbosa : 7 Letras, 2017, 395p.
Nobrezas e hierarquias sociais, séculos XV-XIX
Authors: Silva Camila Borges da , Krause Thiago 
Published: July 2018

Nobrezas e hierarquias sociais, séculos XV-XIX. Apresentação. Revista Maracanan, Rio de Janeiro, Programa de Pós-graduação em História da Universidade do Estado do Rio de Janeiro, n. 18, jul.-dez. 2018.
Regular and Special Education Mexican Teachers’ Attitudes toward School Inclusion and Disability
Authors: Mezquita-Hoyos Yanko Norberto , Sanchez-Monroy Miriam Hildegare , Morales-Martinez Guadalupe Elizabeth , Lopez-Ramirez Ernesto Octavio , Reyna-Gonzalez Maria del Roble 
Published: July 2018

<p style="text-align:justify">The aim of the present study was to elucidate Mexicans teachers’ attitudes toward school inclusion and disability. To achieve this goal, 119 regular education and 88 special education teachers answered The Opinions Relative to Integration of Students with Disabilities scale. Subsequent analyses revealed that attitudes to both groups were similar in terms of direction but dissimilar in magnitude factor. In addition, while the attitude structure in both samples involved three factors, these were unique to each group: Regular education teachers (Perceived Benefits and Negative Effects inside the Inclusive Classroom/Performance inside the Inclusive Classroom, Teaching Ability/Education System, Performance inside the Inclusive Classroom/Education System) and the special education teachers group (Perceived Benefits inside the Inclusive Classroom/Education System, Teaching Ability/Performance inside the Inclusive Classroom, Perceived Benefits and Negative Effects inside the Inclusive Classroom/Performance inside the Inclusive Classroom). Theoretical and applied implications of these findings are discussed in this paper.</p>