bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells
Authors: Silva Zélia , Rabaça João Amorim , Luz Vanessa , Lourenço Rita Adubeiro , Salio Mariolina , Oliveira Alexandra Couto , Bule Pedro , Springer Sebastian , Videira Paula Alexandra 
Published: November 2024

Abstract
Sialic acids at the cell surface of dendritic cells (DCs) play an important immunomodulatory role, and their manipulation enhances DC maturation, leading to heightened T cell activation. Particularly, at the molecular level, the increased stability of surface MHC-I molecules in monocyte-derived DCs (MoDCs) underpins an improved DC: T cell interaction. In this study, we focused on the impact of sialic acid remodelling by treatment with Clostridium perfringens sialidase on MoDCs' phenotypic and functional characteristics. Our investigation juxtaposes this novel approach with the conventional cytokine-based maturation regimen commonly employed in clinical settings.
Notably, C. perfringens sialidase remarkably increased MHC-I levels compared to other sialidases having different specificities, supporting the idea that higher MHC-I is due to the cleavage of specific sialoglycans on cell surface proteins. Sialidase treatment induced rapid elevated surface expression of MHC-I, MHC-II and CD40 within an hour, a response not fully replicated by 48 h cytokine cocktail treatment. These increases were also observable 48 h post sialidase treatment. While CD86 and PD-L1 showed significant increases after 48 h of cytokine maturation, 48 h post sialidase treatment showed a higher increase in CD86 and shorter increase in PD-L1. CCR-7 expression was significantly increased 48 h after sialidase treatment but not significantly affected by cytokine maturation. Both treatments promoted higher secretion of the IL-12 cytokine. However, the cytokine cocktail induced a more pronounced IL-12 production. SNA lectin staining analysis demonstrated that the sialic acid profile is significantly altered by sialidase treatment, but not by the cytokine cocktail, which causes only slight sialic acid upregulation. Notably, the lipid-presenting molecules CD1a, CD1b and CD1c remained unaffected by sialidase treatment in MoDCs, a finding also further supported by experiments performed on C1R cells. Inhibition of endogenous sialidases Neu1 and Neu3 during MoDC differentiation did not affect surface MHC-I expression and cytokine secretion. Yet, sialidase activity in MoDCs was minimal, suggesting that sialidase inhibition does not significantly alter MHC-I-related functions. Our study highlights the unique maturation profile induced by sialic acid manipulation in MoDCs. These findings provide insights into the potential of sialic acid manipulation as a rapid immunomodulatory strategy, offering promising avenues for targeted interventions in inflammatory contexts.
Polymer electrolytes based on PEO and lithium tetraalkoxyborate salts with ionic liquid properties for lithium-based batteries
Authors: Czerwiński Arkadiusz , Słojewska Magdalena , Monikowska Dorota , Pawlak Anita , Chodara Agnieszka , Zygadło-Monikowska Ewa 
Published: November 2024

AbstractThe development of lithium-ion batteries (LIBs) with improved safety features is crucial due to the inherent risks associated with liquid electrolytes, such as fires, explosions, and leakage. This study explores the potential of solid polymer electrolytes (SPEs) based on poly(ethylene oxide) (PEO) and lithium tetraalkoxyborate salts (LiTAB) with ionic liquid properties as a safer alternative. Ionic liquids (ILs) are examined for their high ionic conductivity, wide electrochemical window, and excellent thermal stability, despite their high synthesis costs and viscosity challenges. The study proposes the use of a novel LiTAB salt with an oligomeric star-shaped anion structure that reduces mobility, enhancing lithium ion transference numbers. This IL serves as both a lithium salt and an active plasticizer in PEO-based SPEs, offering potential for 3D printing applications. Experimental results demonstrate that these electrolytes exhibit favorable rheological properties, high ionic conductivities, and significant lithium ion transference numbers, addressing the key limitations of conventional PEO-based electrolytes. The findings suggest that incorporating these LiTAB salts in SPEs could significantly enhance the safety and performance of LIBs, particularly for applications in miniaturized consumer electronics and electronic implants.
Outcomes after robot-assisted radical cystectomy with orthotopic neobladder in women
Authors: Rautiola Juhana , Martini Alberto , Mertens Laura S , Skokic Viktor , Di Gianfrancesco Luca , Bravi Carlo Andrea , Heinzelbecker Julia , Mendrek Mikolaj , Buse Stephan , Ploussard Guillaume , John Hubert , Canda Abdullah Erdem , Balbay Mevlana Derya , Edeling Sebastian , Van Praet Charles , Leyh-Bannurah Sami-Ramzi , Mottrie Alexander , D’Hondt Frederiek , van der Poel Hendrik , Berquin Camille , Dacaestecker Karel , Gaston Richard , Wiklund Peter , Hosseini Abolfazl 
Published: November 2024

Abstract
Purpose
To investigate functional, oncological and complication outcomes in women undergoing robot-assisted cystectomy (RARC) with intracorporeal orthotopic neobladder.

Methods
From a multi-institutional database, we identified females with bladder cancer treated with RARC and intracorporeal orthotopic neobladder. We evaluated the continence rate, short-term oncological outcomes, and complication rates. Analyses were repeated and stratified by the status of preserving gynecological organs.

Results
The study involved 146 patients with the median age 60 years (IQR, 51–66 years). Pelvic organ-preserving procedure (POP) was performed in 77 patients (53%). Overall daytime and nighttime continence rates were 54% and 53%, respectively. For POP, the continence rate was 58% for both daytime and nighttime continence. In the non-POP cohort, the continence rate was 50% for daytime and 49% for nighttime continence. Both groups had balanced positive surgical margin rates (5,3% for POP and 4,7% for non-POP). In the whole cohort, high-grade (Clavien-Dindo ≥3) early and late complication rate was 7,5% and 7,5%, respectively.

Conclusions
Robot-assisted radical cystectomy with intracorporeal orthotopic neobladder in females demonstrate excellent functional and complication outcomes. Pelvic organ-preserving cystectomy enhances urinary continence rates without adversely affecting surgical margins. Orthotopic neobladder in selected women with bladder cancer, along with pelvic organ-preserving cystectomy may be used for improved functional outcomes without compromising oncological results.
Shelter selection in females of two scorpion species depends on shelter size and scent
Authors: Hladik Janina , Bailer Yorick , Wolf Harald , Stemme Torben 
Published: November 2024

AbstractShelter selection is an important task in an animal’s life. Concerning scorpions, little is known on the evaluation of potential shelters and the importance of chemosensation. To address these issues, we conducted a two-choice shelter test in rectangular open field arenas to identify properties rendering shelters attractive for female scorpions of the species E. italicus and M. eupeus. Shelters varied in size (large, small) and scent (none, conspecific: male or female, attractive: prey, aversive: rosemary oil). Contact with the shelters was video-recorded under red light for 13 h, including the whole night phase. Results revealed a preference for larger shelters, with conspecific scent having minor or no influence. Striking differences occurred with regard to prey and rosemary oil scents. Prey scent was more attractive to M. eupeus, while rosemary oil did not act as a repellent. E. italicus was not very attracted by prey scent, but was repelled by rosemary oil. These findings might reflect the different habitats, semi-arid vs. Mediterranean climates: prey and rosemary are scarce in the semi-arid climate (habitat of M. eupeus), whereas they are abundant in the Mediterranean climate (habitat of E. italicus). We carried out impairment experiments to identify the main sensory organs responsible for the above observations. These are the pectines and pedipalps which function as mechano- and chemosensors. Scorpions could not detect size nor scent properly when either their pectines or pedipalps were impaired.
Temporal interaction of suicidal ideations and behaviors with loneliness in persistent depressive disorder – a feasibility study using ecological momentary assessment
Authors: Wolf Johannes , Goerigk Stephan , Midderhoff Franziska , Burkhardt Gerrit , Bühner Markus , Köhler Stephan , Falkai Peter , Jobst Andrea , Padberg Frank , Reinhard Matthias A. 
Published: November 2024

AbstractIndividuals with persistent depressive disorder (PDD) are at increased risk for suicidality. Suicidality may be precipitated by loneliness. However, their temporal interplay in PDD has not been studied. We conducted a feasibility study using ecological momentary assessment (EMA) to measure short-term courses of suicidality and loneliness in 20 inpatients with PDD and current suicidality. EMA adherence of 13 completers was 81.3%. Suicidal ideations and loneliness varied with one standard deviation over three to six hours. This pilot study confirmed the feasibility of EMA in PDD and provided new insights in dynamics of suicidality and loneliness informing future study designs.
Therapeutic drug monitoring in children and adolescents with schizophrenia-spectrum, affective, behavioural, tic and other psychiatric disorders treated with aripiprazole: results of the TDM-VIGIL pharmacovigilance study
Authors: Riegger Jessica , Egberts Karin Maria , Clement Hans-Willi , Schneider-Momm Katja , Taurines Regina , Fekete Stefanie , Wewetzer Christoph , Karwautz Andreas , Correll Christoph U. , Plener Paul L. , Malzahn Uwe , Heuschmann Peter , Unterecker Stefan , Scherf-Clavel Maike , Rock Hans , Antony Gisela , Briegel Wolfgang , Banaschewski Tobias , Hellenschmidt Tobias , Kaess Michael , Kölch Michael , Renner Tobias , Rexroth Christian , Schulte-Körne Gerd , Walitza Susanne , Gerlach Manfred , Romanos Marcel , Fleischhaker Christian 
Published: November 2024

Abstract
Aripiprazole is approved for various severe mental disorders in adults and adolescents. However, off-label prescribing is common, especially in children and adolescents (youth) in whom aripiprazole therapeutic serum level reference ranges are lacking for any disorders. The aim of the study was to evaluate the relationship between aripiprazole dose and serum concentrations and provide further knowledge on the use of aripiprazole in order to improve drug safety and effectiveness in the treatment of minors. The clinical course of youth treated with aripiprazole in the multicentre pharmacovigilance study TDM-VIGIL was systematically followed and serum concentrations measured. Sex, age, weight and comedications were analysed to identify possible effect modifiers. A preliminary therapeutic reference range was estimated for youth with schizophrenia-spectrum disorders, affective disorders and behavioural/emotional/tic disorders coded as treatment responders based on a Clinical-Global Impressions-Improvement (CGI-I) score of much or very much improved. In 93 youth (mean age = 15.2 ± 2.6, range = 7.4–18.2 years, females = 53%, CGI-Severity = 4.4 ± 1.1, responders = 64%), a positive, moderate correlation between the weight-normalized daily dose (WNDD) and aripiprazole serum concentration (=0.791, p < 0.0001) was found. The WNDD and co-medications that interact with CYP2D6 and CYP3A4 affected aripiprazole serum levels, explaining 64% of the variance. In patients within the preliminary therapeutic ranges determined by interquartile ranges (IQRs), slightly better outcomes and fewer adverse drug reactions were found versus patients within preliminary therapeutic ranges determined by the mean ± SD. The preliminary reference range for paediatric patients with schizophrenia-spectrum disorders calculated by the IQR showed an identical lower threshold (100–230 ng/ml) compared to adult schizophrenia-spectrum disorders patients (100–350 ng/ml). The preliminary therapeutic ranges for patients with affective disorders was: 60–160 ng/ml and for patients with behavioural/tic disorders 60–140 ng/ml. The therapeutic reference ranges for aripiprazole in youth estimated via the 25th and 75th IQRs may result in more clinically relevant therapeutic windows. Further studies need to confirm these results, especially in patients with affective and behavioural/tic disorder diagnoses.
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer
Authors: Jubashi Amane , Nakayama Izuma , Koganemaru Shigehiro , Sakamoto Naoya , Oda Shioto , Matsubara Yuki , Miyashita Yu , Sato Seiya , Ushiyama Shinpei , Kobayashi Akinori , Okazaki Ukyo , Okemoto Dai , Yamamoto Kazumasa , Mishima Saori , Kotani Daisuke , Kawazoe Akihito , Hashimoto Tadayoshi , Nakamura Yoshiaki , Kuboki Yasutoshi , Bando Hideaki , Kojima Takashi , Yoshino Takayuki , Miyaaki Hisamitsu , Nakao Kazuhiko , Shitara Kohei 
Published: November 2024

Abstract
Background
Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate targeting HER2-positive gastric cancer or gastroesophageal junction cancer (GC/GEJC). Although effective, T-DXd has notable toxicities, including interstitial lung disease (ILD). This study evaluated the efficacy, safety, and prognostic factors associated with T-DXd for GC/GEJC.

Methods
A retrospective observational study was conducted at our institution by reviewing medical records of patients treated with T-DXd until September 2023. Eligible patients had unresectable advanced or recurrent GC/GEJC, HER2 status of IHC 3 + or IHC 2 + /ISH-positive, and prior treatment with trastuzumab-containing regimen.

Results
Among the 101 patients analyzed, the initial T-DXd dose was 6.4 mg/kg in 77 patients and 5.4 mg/kg in 24 patients. The objective response rate was 54.3%, with a median PFS of 5.4 months and a median OS of 11.4 months. The significant prognostic factors for shorter PFS and OS included ECOG PS ≥ 1, presence of primary lesion, and peritoneal metastasis but not the initial T-DXd dose. ILD occurred in 14.9% of patients. Notably, higher T-DXd dose and smaller tumor burden were associated with a higher incidence of ILD.

Conclusions
Several factors were associated with prognosis after T-DXd treatment in patients with GC/GEJC. Tumor burden is a potential risk factor for T-DXd-related ILD. Further studies are needed to optimize dosing based on tumor burden and to improve the therapeutic index.
Absolute antenna group delay variations: estimation, single station repeatability and their influence on coordinate and float ambiguity estimation in baseline positioning
Authors: Platz Hans Daniel 
Published: November 2024

Abstract
Phase center offsets and variations (PCV) are common corrections applied to global navigation satellite system (GNSS) phase observations in the context of precise point positioning. Similar to PCV are group delay variations (GDV), which affect code observations. In this paper, absolute GDVs, which are independent of a reference antenna, are estimated as antenna- and frequency-specific for the frequencies 1575.42 MHz and 1176.45 MHz, where separation of receiving and transmitting antenna GDV is possible with non-rotating antennas. Nineteen receiving and transmitting antennas of GPS, Galileo, BeiDou, and QZSS satellites, using observations from static reference stations, are considered. The single station repeatability of the receiver antenna GDV i.e., the estimation of the GDV using only one station, is evaluated for all antenna-frequency combinations. The repeatability ranges from 1.1 to 7.6 cm at a zenith angle of 80°, showing significant differences between antennas and frequencies. The estimated GDV corrections are applied to multi-GNSS baseline positioning using a total of 116 baselines. Receiver antenna GDV corrections exhibit a significant non-zero mean effect on the code-based vertical coordinate estimate. Float ambiguities are estimated using observation periods of up to 20 min. The 0.95-quantile effect of the GDV corrections on narrow lane ambiguity estimates is 2.02 cycles at the first epoch and 0.54 cycles after 5 min using 30 s observation sampling. The effect on wide lane ambiguities is constant over the 20-min period considered, with the 0.95-quantile being around 0.1 cycles for the GNSS considered.
Dualizations of Approximations, $$\aleph _1$$-Projectivity, and Vopěnka’s Principles
Authors: Ben Yassine Asmae , Trlifaj Jan 
Published: November 2024

AbstractThe approximation classes of modules that arise as components of cotorsion pairs are tied up by Salce’s duality. Here we consider general approximation classes of modules and investigate possibilities of dualization in dependence on closure properties of these classes. While some proofs are easily dualized, other dualizations require large cardinal principles, and some fail in ZFC, with counterexamples provided by classes of $$\aleph _1$$

ℵ
1

-projective modules over non-perfect rings. For example, we show that the statement “each covering class of modules closed under homomorphic images is of the form $${\mathrm{Gen\,}}(M)$$

Gen

(
M
)

for a module M” is equivalent to Vopěnka’s Principle.
Improving tribological efficiency of isopropyl palmitate oil with cellulose nanocrystals: a sustainable approach for high-performance lubricants
Authors: Guimarey María J. G. , Marcos Marco A. , Vallejo Javier P. , Viesca José L. , Comuñas María J. P. , Lugo Luis , Battez Antolin Hernández 
Published: November 2024

AbstractThis article explores the potential of cellulose nanocrystals (CNCs) as a lubricant additive for isopropyl palmitate (IPP) oil to enhance its tribological performance. CNCs, derived from renewable sources, offer a sustainable and environmentally friendly alternative to traditional lubricant additives. A two-step method was used to prepare the nanolubricants, with visual control and dynamic light scattering measurements to assess their temporal stability. The viscous behavior of the nanolubricants, in terms of viscosity and viscosity index, was evaluated at different temperatures. The study assesses the effectiveness of CNC/IPP oil blends as lubricants through tribological tests, including evaluations under pure sliding and rolling–sliding conditions. Studies on worn surfaces were conducted using surface roughness analysis, Raman mapping, and XPS, and the thermal stability was examined to determine their suitability for different operating conditions. CNCs significantly reduce friction by up to 44% and improve wear resistance compared to the neat IPP base oil, presumably due to a self-repairing effect. Furthermore, an improvement of the thermal conductivity of pure IPP base oil has been revealed with increasing CNC concentration. This study enhances the understanding of cellulose nanocrystals as lubricant additives and their potential to transform traditional lubricating oils into high-performance and sustainable solutions.
A Phenomenological Study of Parentification Experiences of Asian American Young Adults
Authors: Cho Sunjung , Glebova Tatiana , Seshadri Gita , Hsieh Alexander 
Published: November 2024

AbstractThe term ‘parentification’ describes role-reversed family processes when children provide care to their parents and family. Given the fact that race and ethnicity are among the least considered factors in the past research on parentification, the purpose of this phenomenological study was to understand the lived experiences of parentification of young Asian American adults within their sociocultural context using the contextual therapy theory. Eight individuals (five identified as Hmong, two as lu Mien, and one as Filipino), seven females and one male, ages ranging from 24 to 29, participated in semi-structured interviews. Data were analyzed using reflexive thematic analysis from which the predominant themes of early and extensive parentification experiences as children of immigrant parents, strong influences of cultural expectations, and lost childhood and identity emerged. Furthermore, the study participants complied with gender-based cultural role expectations to help their families survive. Clinical implications and study limitations are discussed.
Factors Associated with Suicidal Behavior in Adolescents: An Umbrella Review Using the Socio-Ecological Model
Authors: Prades-Caballero Virginia , Navarro-Pérez José-Javier , Carbonell Ángela 
Published: November 2024

Abstract
Adolescent suicide is a critical social issue with profound and lasting individual and collective consequences. This umbrella review examines factors associated with adolescent suicidal behavior through the socioecological framework of prevention and seeks to identify gaps in the existing literature. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included a comprehensive search of the of the Web of Science, Scopus, and Cochrane databases in both English and Spanish, covering the period from 2018 to 2024, using terms related to adolescence and suicidal behavior. Out of 6,138 articles identified, 37 met the quality criteria and were selected for analysis. The studies highlighted individual risk factors such as age, gender, belonging to ethnic or gender minorities, emotional disorders, self-destructive behavior, emotional regulation, and experience of physical or emotional pain. Interpersonal factors such as parental relationships, sexual abuse, social isolation, peer pressure, and loneliness were also found. However, the review revealed a worrying lack of studies on societal and community factors and a paucity of research focusing on protective factors. The study highlights the need to include factors related to the physical and social environments that influence health and behavior in future research, as well as to enhance the resources and strengths of adolescents.
Right-angled links in thickened surfaces
Authors: Kaplan-Kelly Rose 
Published: November 2024

AbstractTraditionally, alternating links are studied with alternating diagrams on $$S^2$$

S
2

in $$S^3$$

S
3

. In this paper, we consider links which are alternating on higher genus surfaces F in thickened surface $$F \times I$$

F
×
I

. We define what it means for such a link to be right-angled generalized completely realizable (RGCR) and show that this property is equivalent to the link having two totally geodesic checkerboard surfaces, equivalent to each checkerboard surface consisting of one type of polygon, and equivalent to a set of restrictions on the link’s alternating projection diagram. We then use these diagram restrictions to classify RGCR links according to the polygons in their checkerboard surfaces, provide a bound on the number of RGCR links for a given surface of genus g, and find a right-angled knot in a thickened surface. Along the way, we answer a question posed by Champanerkar, Kofman, and Purcell about links with alternating projections on the torus.