bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting principals’ adoption of and satisfaction with market-driven externally developed reforms
Authors: Schwabsky Nitza 
Published: March 2018

Purpose
The purpose of this paper is to explore the motives, opportunities, and threats associated with the adoption of market-driven externally developed reforms (EDRs) as well as how these motivator factors, combined with background variables, account for school principals’ satisfaction with EDR adoption.

Design/methodology/approach
Principals from 208 Israeli schools (grades 1-9) completed anonymous self-report questionnaires about the factors motivating their decision to implement EDRs and their satisfaction with these reform programmes in their schools. Validity and reliability tests, bivariate correlations and Pearson tests, paired t-tests, and a step-by-step multiple regression analysis were performed to examine the associations between the independent variables (individual and institutional variables, and motives, opportunities, and threats), and principals’ satisfaction with aspects of the EDRs.

Findings
Participants reported opportunities in the areas of pedagogy, learning excellence, teacher growth, and school climate. Threats were moderate-low and related to school faculty resistance, principals’ dependence on stakeholders, and difficulties in implementing EDRs. Of the political and the pedagogic motives, the latter was the sole motive associated with principals’ satisfaction with the EDRs. Findings fit within Herzberg’s two-factor theory and Festinger’s cognitive dissonance theory.

Originality/value
Studies on the factors motivating adoption of EDRs are scarce; this is the first to explore motivators’ effects on principals’ satisfaction. It is likely to help principals and decision makers in educational institutions construe the varied factors that affect the adoption of EDRs from senior officials’ viewpoints. Understanding these factors is highly important to the field worldwide because of the growing need to adopt EDRs.
Investigating students’ migration decisions in the frame of career management in higher education institutions of Latvia
Authors: Stukalina Yulia , Roskosa Antra , Pavlyuk Dmitry 
Published: March 2018

Purpose
The purpose of this paper is to identify the main students’ motivators for their migration decisions, which can be used by education managers working in the area of career management in higher education institutions of Latvia.

Design/methodology/approach
Performed empirical data analysis is based on a survey data, collected from students of various educational programmes in two higher education institutions of Latvia. The data analysis consisted of three steps: initial exploratory data analysis (including testing for sample homogeneity, and sample descriptive statistics), correspondence analysis of student’s answers (including testing for survey reliability, discrimination measures and dimension reduction) and analysis of relationships between survey questions (including contingency tables, testing for directional associations and the logistic regression).

Findings
The results of the study show that students’ career motivators are significant explanatory factors for their migration decisions. According to the survey results, the main reasons for migration decisions are better career prospects, a higher salary, new professional experience and share of own experience, new professional contacts, motivating and interesting job, better training facilities and the support of their family members and friends who are working or studying abroad.

Research limitations/implications
First, the sample in this study included two higher education institutions. Second, the same respondents participated in both the qualitative and quantitative aspects of the research. Future study with a more diverse student population and the refined scale items is recommended to verify and generalise the findings.

Practical implications
The paper addresses policy makers at the national level and education managers responsible for career guidance activities. The conducted analysis has allowed the authors to provide some recommendations for education managers working in the area of career guidance and counselling in Latvia. However, as education managers in the Baltic states face similar challenges, the results might be also used by managers working in other Baltic states.

Originality/value
The empirical study performed in the paper has attempted to investigate the influence of students’ career drivers on their migration decisions in the framework of career management in higher education institutions.
Headteacher-teacher relationship and its effect on teacher’s trust in Malaysian high performing schools
Authors: Musah Mohammed Borhandden , Abdul Rahman Rozanne Emilia , Tahir Lokman Mohd , Al-Hudawi Shafeeq Hussain Vazhathodi , Daud Khadijah 
Published: March 2018

PurposeThe purpose of this paper is to examine the relationship between headteachers and teachers and its effects on the role of trust in Malaysian high-performing schools through the dyadic relationship theoretical approach.Design/methodology/approachUsing a survey questionnaire, a total of 199 teachers from five high-performing schools were selected as respondents for data collection. Before proceeding with inferential statistical analysis, teachers were separated into the “in-group” and “out-group”.FindingsThe findings revealed that the teachers from both the groups perceived that their facets of trust are strongly associated with the type of relationship they have with their school leaders. The results also demonstrate that the quality of dyadic relationships between headteachers and teachers moderately influences teachers’ trust.Practical implicationsThe findings suggest that the headteachers should always build good relationships with the teachers to gain teachers’ trust for sustaining school effectiveness. The findings encourage the Ministry of Education, particularly the Teacher Recruitment Division, to require all teachers and headteachers to deepen their knowledge on leader-member exchange (LMX) role-development processes.Originality/valueThe results are of great importance since limited empirical studies have examined LMX role-development processes with reference to teachers and headteachers in the context of Malaysian higher performing schools.
Time-varying synchronization and dynamic conditional correlation among the stock market returns of leading South American economies
Authors: Panda Ajaya Kumar , Nanda Swagatika 
Published: March 2018

Purpose
The purpose of this paper is to capture the pattern of return volatility and information spillover and the extent of conditional correlation among the stock markets of leading South American economies. It also examines the connectedness of market returns within the region.

Design/methodology/approach
The time series properties of weekly stock market returns of benchmark indices spanning from the second week of 1995 to the fourth week of December 2015 are analyzed. Using univariate auto-regressive conditional heteroscedastic, generalized auto-regressive conditional heteroscedastic, and dynamic conditional correlation multivariate GARCH model approaches, the study finds evidence of returns and volatility linkages along with the degree of connectedness among the markets.

Findings
The findings of this study are consistent with increasing market connectedness among a group of leading South American economies. Stocks exhibit relatively fewer asymmetries in conditional correlations in addition to conditional volatility; yet, the asymmetry is relatively less apparent in integrated markets. The results demonstrate that co-movements are higher toward the end of the sample period than in the early phase. The stock markets of Argentina, Brazil, Chile, and Peru are closely and strongly connected within the region followed by Colombia, whereas Venezuela is least connected with the group.

Practical implications
The implication is that foreign investors may benefit from the reduction of the risk by adding the stocks to their investment portfolio.

Originality/value
The unique features of the paper include a large sample of national stock returns with updated time series data set that reveals the time series properties and empirical evidence on volatility testing. Unlike other studies, this paper uncovers the relation between the stock markets within the same region facing the same market condition.
Impacts of supply chain planning and integration on mass customization
Authors: (Jason) Liu Gensheng , Zhang Weiyong , Guo Chundong 
Published: March 2018

PurposeEffective mass customization (MC) depends on accurately identifying customer needs and procuring appropriate components from supply base to manufacture the required product configurations in a timely manner. In essence, effective MC for a focal firm is contingent on effective supply chain management. However, extant literature is not very clear on how supply chain (SC) planning and integration activities affect MC. The purpose of this paper is to fill the gap by examining the impacts of SC-planning and SC-integration on MC.Design/methodology/approachOrganizational information processing theory is used to link SC-integration with MC ability, and a link is hypothesized between SC-planning and SC-integration. The structural equation model is then analyzed using data from 262 manufacturing plants.FindingsIt is found that SC-integration fully mediates the relationship between SC-planning and MC-ability.Research limitations/implicationsThe SC-integration measure is from a focal manufacturer’s standpoint, rather than the standpoint of the entire SC.Practical implicationsThe results indicate that using a SC perspective in planning activities helps a focal firm integrate with key stakeholders along the SC, which subsequently helps the firm mass customize. Practitioners should recognize the added importance of SC-planning and SC-integration if they want to mass customize.Originality/valueThis study provides a theoretical foundation for the relationship between SC-integration and MC. It also provides a more comprehensive conceptualization of SC-integration, which includes supplier integration, customer integration, as well as internal functional integration which was neglected in many previous studies.
Characterisation of Cu/Cu bonding using self-assembled monolayer
Authors: Lykova Maria , Panchenko Iuliana , Künzelmann Ulrich , Reif Johanna , Geidel Marion , Wolf M. Jürgen , Lang Klaus-Dieter 
Published: March 2018

Purpose
Cu/Cu diffusion bonding is characterised by high electrical and thermal conductivity, as well as the mechanical strength of the interconnects. But despite a number of advantages, Cu oxidises readily upon exposure to air. To break through the adsorbed oxide-layer high temperature and pressure, long bonding time and inert gas atmosphere are required during the bonding process. This paper aims to present the implementation of an organic self-assembled monolayer (SAM) as a temporary protective coating that inhibits Cu oxidation.

Design/methodology/approach
Information concerning elemental composition of the Cu surface has been yielded by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared (FTIR) spectroscopy. Two types of substrates (electroplated and sputtered Cu) are prepared for thermocompression bonding in two different ways. In the first case, Cu is cleaned with dilute sulphuric acid to remove native copper oxide. In the second case, passivation with SAM followed the cleaning step with dilute sulphuric acid. Shear strength, fracture surface, microstructure of the received Cu/Cu interconnects are investigated after the bonding procedure.

Findings
The XPS method revealed that SAM can retard Cu from oxidation on air for at least 12 h. SAM passivation on the substrates with sputtered Cu appears to have better quality than on the electroplated ones. This derives from the results of the shear strength tests and scanning electron microscopy (SEM) imaging of Cu/Cu interconnects cross sections. SAM passivation improved the bonding quality of the interconnects with sputtered Cu in comparison to the cleaned samples without passivation.

Originality/value
The Cu/Cu bonding procedure was optimised by a novel preparation method using SAMs which enables storage and bonding of Si-dies with Cu microbumps at air conditions while remaining a good-quality interconnect. The passivation revealed to be advantageous for the smooth surfaces. SEM and shear strength tests showed improved bonding quality for the passivated bottom dies with sputtered Cu in comparison to the samples without SAM.
Ago2 and Dicer1 are involved in METH‐induced locomotor sensitization in mice via biogenesis of miRNA
Authors: Liu Dan , Zhu Li , Ni Tong , Guan Fang‐lin , Chen Yan‐jiong , Ma Dong‐liang , Goh Eyleen L.K. , Chen Teng 
Published: March 2018

AbstractmicroRNA (miRNA) play important roles in drug addiction and act as a post‐transcriptional regulator of gene expression. We previously reported extensive downregulation of miRNAs in the nucleus accumbens (NAc) of methamphetamine (METH)‐sensitized mice. However, the regulatory mechanism of this METH‐induced downregulation of miRNAs has yet to be elucidated. Thus, we examined METH‐induced changes in the expression of miRNAs and their precursors, as well as the expression levels of mRNA and the proteins involved in miRNA biogenesis such as Dicer1 and Ago2, in the nucleus accumbens of METH‐induced locomotor sensitized mice. miRNAs and Ago2 were significantly downregulated, while the expression of miRNA precursors remained unchanged or upregulated, which suggests that the downregulation of miRNAs was likely due to a reduction in Ago2‐mediated splicing but unlikely to be regulated at the transcription level. Interestingly, the expression level of Dicer1, which is a potential target of METH‐induced decreased miRNAs, such as miR‐124, miR‐212 and miR‐29b, was significantly increased. In conclusion, this study indicates that miRNA biogenesis (such as Ago2 and Dicer1) and their miRNA products may have a role in the development of METH addiction.
Do FHIT gene alterations play a role in human solid tumors?
Authors: Silveira Zavalhia Lisiane , Weber Medeiros Aline , Oliveira Silva Andrew , Vial Roehe Adriana 
Published: March 2018

AbstractThe fragile histidine triad (FHIT) gene encloses an active common chromosomal fragile site, FRA3B. This gene is known to be associated with genomic instability, apoptosis and DNA damage. FHIT disturbances have been related to carcinogenesis in different types of human tumor. Despite this, there are some controversies about the exact role of the FHIT gene in relation to tumor biology. Several pieces of evidence support the hypothesis that FHIT acts as a tumor suppressor gene. A loss or decrease in the Fhit protein expression appears to be related to tumor progression, poor prognostic factors and lower survival rates. The most frequent causes of FHIT expression changes are gene mutations, epigenetic alteration and loss of heterozygosity. This literature review aims to clarify the involvement of the FHIT gene in carcinogenesis, tumor progression and clinical outcome in prevalent solid malignancies, such as breast, lung, cervical, esophageal, gastric and colorectal cancers.
The effect of a major earthquake experienced during the first trimester of pregnancy on the risk of preterm birth
Authors: Hawkins Georgina , Gullam Joanna , Belluscio Laura 
Published: March 2018

BackgroundOn 22 February 2011 an earthquake (magnitude 6.3) hit Christchurch, New Zealand. Earthquakes have been associated with increased risks of preterm birth (PTB) and other adverse pregnancy outcomes. However, the literature on this subject is scarce. Maternal antenatal stress has been suggested as the link between earthquakes and PTB. In this study the Christchurch earthquake was utilised as a model of maternal stress to assess its effects on PTB rates and other pregnancy outcomes.AimTo investigate whether women who experienced a major earthquake during the first trimester of pregnancy were at an altered risk of PTB compared to women who did not experience an earthquake during their pregnancy.MethodsThis was a retrospective cohort study. Women carrying a singleton pregnancy in their first trimester on 22 February, 2011 were identified for a post‐earthquake cohort (n = 1057). A group of women pregnant in 2009 were identified for a pre‐earthquake cohort (n = 1314). Data were obtained from electronic medical records and the hospital clinical coding database. Chi‐square test, Fisher's exact test and Wilcoxon rank sum test were used to analyse differences in pregnancy outcomes. Statistically significant variables together with earthquake exposure were assessed as risk factors for PTB using a multivariate logistic regression model.ResultsNo significant difference in the rate of PTB was found between the two groups P > 0.05).ConclusionWomen carrying a singleton pregnancy in this study who experienced a major earthquake in their first trimester do not seem to be at an increased risk of PTB.
Direct‐acting antiviral treatment for hepatitis C virus infection and risk of incident liver cancer: a retrospective cohort study
Authors: Singer A. W. , Reddy K. R. , Telep L. E. , Osinusi A. O. , Brainard D. M. , Buti M. , Chokkalingam A. P. 
Published: March 2018

SummaryBackgroundEradication of hepatitis C virus (HCV) infection via interferon‐based treatment lowers hepatocellular carcinoma risk; some research suggests this effect extends to interferon‐free treatment.AimsThe objective of this retrospective cohort study was to examine the association of direct‐acting antiviral (DAA) exposure with risk of incident liver cancer in real‐world data.MethodsFrom United States administrative claims data through March 31, 2017, we identified 30 183 adult HCV patients exposed to DAAs. For comparison, we identified contemporary adult HCV patients without evidence of HCV treatment (N = 137 502), and historical HCV patients treated with interferon prior to the introduction of DAAs (N = 12 948). Included patients had at least 12 months of prior enrolment and no evidence of prior liver cancer at baseline. Hazard ratios (HRs) estimating risk of incident liver cancer associated with DAA treatment were calculated using Cox proportional hazards methods.ResultsRelative to untreated HCV patients, DAA‐treated patients were older, more likely to be male, and more likely to have cirrhosis at baseline. After adjustment, DAA treatment was associated with a significantly reduced risk of liver cancer relative to no treatment (adjusted HR = 0.84, 95% CI: 0.73‐0.96), and relative to interferon‐based treatment in the pre‐DAA era (HR = 0.69, 95% CI: 0.59‐0.81).ConclusionsIn this large, population‐based study, DAA‐based treatment was associated with a reduced risk of incident liver cancer relative to both no HCV treatment and to interferon‐based treatment in the pre‐DAA era. As additional follow‐up time of DAA‐treated patients accrues, we anticipate that the long‐term benefits of DAA treatment will become more apparent.
Depression and anxiety during pregnancy: The influence of maternal characteristics
Authors: van de Loo Kim F. E. , Vlenterie Richelle , Nikkels Sylke J. , Merkus Peter J. F. M. , Roukema Jolt , Verhaak Chris M. , Roeleveld Nel , van Gelder Marleen M. H. J. 
Published: March 2018

AbstractBackgroundDepression and anxiety during pregnancy are associated with adverse health outcomes for both mother and child. This study aims to investigate the occurrence of symptoms of depression and anxiety in early and late pregnancy, the longitudinal changes from early to late pregnancy, and factors associated with symptoms of depression and anxiety in pregnant women in the Netherlands.MethodsWe studied 2897 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study. To assess symptoms of depression and anxiety, web‐based questionnaires including the Hospital Anxiety and Depression Scale (HADS) and multiple questions on maternal characteristics were completed in early and late pregnancy. Cross‐sectional and longitudinal multivariable linear regression analyses were conducted.ResultsThe depressive symptoms in our population increased, with a prevalence of probable depression from 5.4% in early pregnancy to 10.0% in late pregnancy (P < .001), whereas the anxiety symptoms decreased, with a prevalence of probable anxiety from 17.9% to 14.2% (P < .001). Characteristics associated with depressive or anxiety symptoms included low level of education, multiparity, a history of depression, severe nausea, extreme fatigue, lack of physical exercise, and negative life events. Being non‐Dutch, not living with a partner, and having an unplanned pregnancy or a long time to pregnancy were associated with the depressive and/or anxiety symptoms in early pregnancy only.DiscussionSymptoms of depression and anxiety are common in both early and late pregnancy. Screening for risk factors in early pregnancy is important, since prenatal depression and anxiety may be related to adverse maternal and child health outcomes.
Cerebellar α6‐subunit‐containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders
Authors: Chiou Lih‐Chu , Lee Hsin‐Jung , Ernst Margot , Huang Wei‐Jan , Chou Jui‐Feng , Chen Hon‐Lie , Mouri Akihiro , Chen Liang‐Chieh , Treven Marco , Mamiya Takayoshi , Fan Pi‐Chuan , Knutson Daniel E , Witzigmann Chris , Cook James , Sieghart Werner , Nabeshima Toshitaka 
Published: March 2018

Background and PurposeThe pathophysiological role of α6‐subunit‐containing GABAA receptors, which are mainly expressed in cerebellar granule cells, remains unclear. Recently, we demonstrated that hispidulin, a flavonoid isolated from a local herb that remitted a patient's intractable motor tics, attenuated methamphetamine‐induced hyperlocomotion in mice as a positive allosteric modulator (PAM) of cerebellar α6GABAA receptors. Here, using hispidulin and a selective α6GABAA receptor PAM, the pyrazoloquinolinone Compound 6, we revealed an unprecedented role of cerebellar α6GABAA receptors in disrupted prepulse inhibition of the startle response (PPI), which reflects sensorimotor gating deficits manifested in several neuropsychiatric disorders.Experimental ApproachPPI disruptions were induced by methamphetamine and NMDA receptor antagonists in mice. Effects of the tested compounds were measured in Xenopus oocytes expressing recombinant α6β3γ2SGABAA receptors.Key ResultsHispidulin given i.p. or by bilateral intracerebellar (i.cb.) injection rescued PPI disruptions induced by methamphetamine, ketamine, MK‐801 and phencyclidine. Intracerebellar effects of hispidulin were mimicked by Ro15‐4513 and loreclezole (two α6GABAA receptor PAMs), but not by diazepam (an α6GABAA receptor‐inactive benzodiazepine) and were antagonized by furosemide (i.cb.), an α6GABAA receptor antagonist. Importantly, Compound 6 (i.p.) also rescued methamphetamine‐induced PPI disruption, an effect prevented by furosemide (i.cb.). Both hispidulin and Compound 6 potentiated α6β3γ2SGABAA receptor‐mediated GABA currents.Conclusions and ImplicationsPositive allosteric modulation of cerebellar α6GABAA receptors rescued disrupted PPI by attenuating granule cell activity. α6GABAA receptor‐selective PAMs are potential medicines for treating sensorimotor gating deficits in neuropsychiatric disorders. A mechanistic hypothesis is based on evidence for cerebellar contributions to cognitive functioning including sensorimotor gating.