bluuebunny/crossref_metadata_2025_split huggingface dataset:
Track Maneuvering using PID Control for Self-driving Cars
Authors: Farag Wael 
Published: March 2019

Background:
In this paper, a Proportional-Integral-Differential (PID) controller that facilitates
track maneuvering for self-driving cars is proposed.

Methods:
Three different design approaches are used to find and tune the controller hyperparameters.
One of them is “WAF-Tune”, which is an ad hoc trial-and-error based technique that is
specifically proposed in this paper for this specific application. The proposed controller uses only
the Cross-Track-Error (CTE) as an input to the controller, whereas the output is the steering command.

Results:
Extensive simulation studies in complex tracks with many sharp turns have been carried out
to evaluate the performance of the proposed controller at different speeds.

Conclusion:
The analysis shows that the proposed technique outperforms the other ones. The usefulness
and the shortcomings of the proposed tuning mechanism are also discussed in details.
Modulation of Shape and Size-Dependent Characteristics of Nanoparticles
Authors: Sharma Rashmi , Sharma Pramod K. , Malviya Rishabha 
Published: March 2019

Background:
Nanoparticles have considerably been studied for biomedical
applications which include biosensing, bioimaging diagnostics, etc. but the effect of
shape and size on the nanoparticles has received little attention. The execution of
nanoparticles is affected by various factors such as size, shape, surface charge, etc.

Objective:
In this manuscript, the effects of nanoparticles size and shape on cellular uptake,
biodistribution, and half-life of nanoparticles are discussed. The shape of nanoparticles
affects the biodistribution, cellular uptake, adhesion strength, half-life circulation,
and drug release kinetics and drug clearance.

Methods and Results:
The shape of the particles enhances the distribution ratio. Particles
with a different shape such as spherical shape particles, improve oral drug bioavailability.
Rod-like structure of particles showed more specific uptake and less nonspecific uptake
in cells related to sphere particles. The size of the particles also affects the binding properties
to the receptor and the enthalpic and entropic properties to control the adhesive
strength in nanoparticles. Maximum in vitro cellular uptake showed a 10-60nm size
range. Nanoparticles that are more than 100nm in size have the ability to penetrate
through leaky vasculature into tumors. The size of the nanoparticles affects the biological
fate and the large size particles are accumulated in the liver and spleen.

Conclusion:
The present manuscript specifically deals with the nanocarrier formulation
such as cubosomes and hexasomes. The nanoparticles shape has an impact on hydrodynamics
significantly and interfaces of vascular targeting. Due to the small particle size of
the cubosomes nanoparticles, the cubic phase is more appropriate for the controlled release
drug delivery system. It can be concluded from the findings of the literature survey
that the size and shape of nanocarriers have a significant effect on pharmaceutical and
biomedical adaptation.
Distribución potencial y abundancia de candelilla (Euphorbia antisyphilitica) en el norte de Zacatecas, México
Authors: Bañuelos-Revilla José Enrique , Palacio-Núñez Jorge , Martínez-Montoya Juan Felipe , Olmos-Oropeza Genaro , Flores-Cano Jorge Alberto 
Published: March 2019

En las zonas áridas de México habita la candelilla (Euphorbia antisyphilitica), especie con importancia social y económica, pero cuya disponibilidad no está bien definida. El objetivo de este trabajo fue estimar su distribución potencial y abundancia en el norte del estado de Zacatecas. Para la distribución potencial se realizó un modelado mediante el algoritmo MaxEnt®, donde se usaron 18 registros de presencia: 8 históricos y 10 propios, así como 27 variables predictivas. Se cotejó en campo la presencia mediante 29 puntos aleatorios en el área con distribución potencial y otros 19 fuera de ella. La densidad poblacional se estimó mediante parcelas, se midió la talla de los ejemplares y se consideraron las variables: tipo de vegetación y de suelo, altitud y pendiente del terreno y se realizó la prueba de Kruskal-Wallis. El modelo presentó buena predicción (AUC = 0.920), donde 11 variables contribuyeron con 82.1% en la distribución potencial y las más importantes fueron: tipo de vegetación, exposición, pendiente, altitud y cobertura vegetal. La distribución potencial se encontró en 19.2% del total del área de estudio; la densidad poblacional fue de 295 767.3 individuos por kilómetro cuadrado, influida significativamente por el tipo de vegetación y altitud. La talla de las plantas fue significativamente menor en pendiente escarpada. En 37.9% de los puntos de validación con distribución potencial hubo resultados positivos de presencia de la especie, sin embargo, en 10.5% fuera del área de distribución potencial también apareció. Se concluye que mediante la utilización del algoritmo MaxEnt® se puede modelar la distribución potencial de plantas silvestres, como la candelilla; la distribución potencial fue discontinua y menor a 20%.
Phytochemical analysis, proximate composition and antibacterial activities of Ziziphus Species (Z. jujube and Z. spina christi)
Authors: Alhassan Kamalu Abdullahi , Indabawa Aisha Shuaibu , Shah M. Manjur 
Published: March 2019

Despite tremendous progress in human medicines infectious diseases caused by bacteria, fungi, viruses and parasites are still a major threat to public health. Their impact is particularly large in developing countries due to relative unavailability of medicines and emergence of widespread drugs resistance (Zampini 2009).The aim and objectives of this research work was designed to carried out the Phytochemical analysis, proximate composition and evaluate the antimicrobial activities of the Ziziphus jujube and Ziziphus spina christi leaves against clinical bacterial isolates (Escherichia coli, Staphloccoccus aureus and Klebsiella pneumoniae) as they were found out that since ancient times to date, they are used in treating various antimicrobial, ailmentand disorders etc. The results of the research shows that, the effect of antibacterial activities of both aqueous and ethanolic extracts of Ziziphus jujube (e extract conc. aqueous; F=119.37, Bacterial extract conc. aqueous; F=1.00 and extract conc. ethanol; F=15.74, Bacterial extract conc. ethanol; F=0.59) are reciprocal proportional to their counterpart, Ziziphus spina-christi (extract conc. aqueous; F=54.96, Bacterial extract conc. aqueous; F=0.94 and extract conc. ethanol; F=81.11, Bacterial extract conc. ethanol; F=1.37). In sum, the minimum inhibitory concentration of Ziziphus jujube shows that, the aqueous extract has M.I.C at range of 11.7 to 8.7mg/ml on all tested bacteria but the ethanolic extract has M.I.C of 14.8 to 8.2mg/ml range on E.coli, Klepsiella spp and S. aureus. While, the minimum inhibitory concentraton of Ziziphus spina-christi shows that the M.I.C of aqueous extract range of 12.8 to 8.3mg/ml on E. coli, Klepsiella spp and S.aureus. But, Ziziphus spina-christi M.I.C of ethanolic extract is 13.5 to 8.8mg/ml on all the tested bacteria. In sum, Zizuphus spina-christi has lower nutritional content and low MIC ethanolic extract than that of Ziziphus jujube.
Síndrome de Activación Macrofágica con paniculitis histiocítica citofágica en pediatría: reporte de caso
Authors: Vásquez Dulce , Rodríguez George , Soto Jatnna 
Published: March 2019

Introducción: El síndrome de activación macrofágica (SAM) es una entidad poco frecuente del sistema fagocítico-mononuclear, caracterizada por la activación benigna de macrófagos en la medula ósea, hígado, bazo y/o ganglios linfáticos asociada a alteraciones genéticas, mutaciones en el gen perforina 1 (PRF1), infecciones virales, fúngicas o bacterianas, neoplasias hematológicas, inmunodeficiencias o enfermedades autoinmunes.
Material y métodos: Al tratarse de una patología poco documentada debido a la confusión generada por los diversos nombres que ha recibido en la literatura, por su cercanía con otras patologías que cursan con un cuadro clínico muy similar, como lo es el Síndrome Hemofagocítico (SHF); presentamos el caso de un varón de 13 años de edad con síndrome de activación macrofágica, con paniculitis histiocítica citofágica de buen pronóstico, de origen esporádico.
Conclusión: La terapia con corticoesteroides en dosis baja es un punto por evaluar en esta patología, debido a la buena respuesta del tratamiento en este caso particular. Asimismo, la importancia de una intervención y manejo precoz que reduzcan considerablemente el riesgo de progresión a falla multiorgánica y la mortalidad por el síndrome.
Scientific literacy profile in biological science of high school students
Authors: R Novaristiana , Rinanto Yudi , Ramli Murni 
Published: March 2019

Scientific literacy is very important for students, so that they can live in the 21st-Century, including solving problems that occur in everyday life. This study was aimed to get an overview of the high school students’ scientific literacy profile in biology learning in the Surakarta City, Central Java, Indonesia. This research was ex-post-facto, looking at the effects of school type and school status. The population was 8750 students from General High Schools, Vocational High Schools, and Islamic High Schools. The sample of 334 students was selected using the proportionate stratified random sampling. The data were collected using scientific literacy tests. The test instrument was prepared by translating the PISA tests on biology from 2006 to 2015 into Indonesian. The test does not take place simultaneously in all schools. The results showed the high school students’ biological science literacy in Surakarta City was very low, except for the private IHSs students, who gained the low category. If viewed from the trend of the achievement levels, high school students in Surakarta City get the lowest achievement level at level 6 and highest at level 5. It concluded the high school students’ scientific literacy in Surakarta City were very low.
Reasoning patterns and modes of prospective biology teachers on embryology learning with TPACK framework
Authors: Nurdiani Nia , Rustaman Nuryani Y. , Setiawan Wawan , Priyandoko Didik 
Published: March 2019

The study was aimed at determining the effectiveness of learning using TPACK (Technological Pedagogical and Content Knowledge) framework in helping the change of reasoning patterns and modes of Biology prospective teachers so that it facilitates in encompassing the Embryology as one of abstract concepts. The subjects used were 49 students of Biology teachers who were having a contract in Embryology course in Biology Education Study Program, in a private educational institute in Bandung. The research design used was quasi-experimental with time-series design type. The measurement of the level of reasoning ability, patterns, and modes of the students were done through the Test of Logical Thinking (ToLT) three times (before the learning program takes place, after learning the first four main subjects, and after the learning program was over). The results showed that the Embryology learning with TPACK framework could directly change the from concrete and transitional reasoners categories to formal reasoners. The learning with TPACK framework also influenced the shift of the students’ logical thinking modes; from the ownership of proportional and/or correlational mode to the ownership of two or three reasoning modes between proportional, probability, correlational, and combinatorial, except the variable control mode.
Self-Determination: Motivational Profiles of Bachelor’s Degree Seeking Students at an Online, For-Profit University
Authors: Pugh Carol 
Published: March 2019

Grounded in the self-determination theory, this exploratory quantitative study investigated motivational profiles of bachelor’s degree seeking students at an online, for-profit university. Cluster analysis revealed two distinct motivational profiles (internally and externally regulated) of 158 students enrolled in a bachelor’s degree program. The significant differences between the two profiles offers support for the multidimensional nature of motivation as argued by self-determination theory. A chi-square test of independence revealed a significant association between motivational profile membership and gender. No associations were found between motivational profile membership and age. The results offer insights into the motivations of bachelor’s degree seeking students attending an online, for-profit university. Over two-thirds of the students in this study exhibited high external forms of motivation. It is recommended practitioners employ methods to increase autonomous forms of motivation in the online, for-profit educational setting. Understanding student motivations to graduate may help administrators, curriculum designers, and instructors develop focused interventions and best practices that could be used to increase graduation rates.
«Góngora», de Giulia Poggi
Authors: Candeloro Antonio 
Published: March 2019

Reseña del libro Góngora, de Giulia Poggi (Roma, Salerno Editrice, 2019).
Se trata de una monografía destinada a convertirse en referencia para todo aquel que quiera acercarse a la obra de uno de los poetas más emblemáticos del Siglo de Oro español. Desde las obras de la juventud, hasta las grandes obras maestras de la madurez, la hispanista italiana nos ofrece un panorama completo y detallado de las múltiples y contrastadas interpretaciones a que ha dado lugar la "nueva poesía" del escritor andaluz.
BEARD, Mary. SPQR: Uma história da Roma Antiga. Trad. Luis Reyes Gil. São Paulo: Planeta, 2017. 576 p. ISBN 978-85-422-0940-2
Authors: Braz Azenathe Pereira 
Published: March 2019

Resenha crítica de SPQR: Uma História da Roma Antiga, de Mary Beard, publicado em 2017, pela editora Planeta.
Il Poeta tra la Folla della Roma di Augusto
Authors: Galasso Luigi 
Published: March 2019

I poeti augustei hanno un’attitudine complessa nei confronti delle cerimonie pubbliche. In alcune delle sue Odi, soprattutto del IV libro, Orazio vuole essere visto come uno tra molti nella sua celebrazione del princeps. Si tratta di componimenti con molti livelli di significato, che mostrano un’interessante dialettica tra l’aspetto pubblico e quello privato ed un particolare rapporto con i modelli poetici greci, arcaici ed ellenistici. Ovidio sviluppa questi spunti nelle sue elegie dell’esilio per dare vita ad una nuova poesia panegiristica.
Atrial conduit function quantitation precardioversion predicts early arrhythmia recurrence in persistent atrial fibrillation patients
Authors: Giubertoni Ailia , Boggio Enrico , Ubertini Esther , Zanaboni Jacopo , Calcaterra Eleonora , Degiovanni Anna , Bellacosa Ilaria , Marino Paolo N. 
Published: March 2019

Aims
Atrial fibrillation incidence is increasing due to ageing population and electrical cardioversion (ECV) is overused because of atrial fibrillation recurrences. Study's aim was to evaluate value of novel three-dimensional echocardiographic-derived left atrial conduit (LAC) function quantification in predicting early atrial fibrillation recurrence after ECV.

Methods
We included 106 patients [74 (64–78) years] who underwent ECV for persistent nonvalvular atrial fibrillation. For all clinical data and simultaneous left atrial and left ventricular (LV) three-dimensional full-volume data sets were available before ECV. We computed LAC as: [(LV maximum − LV minimum) − (left atrial maximum − left atrial minimum) volume], expressed as % LV stroke volume. Atrial fibrillation recurrence was checked with Holter monitoring.

Results
One month after ECV 66 patients were in sinus rhythm and 40 experienced atrial fibrillation recurrence. Pre-ECV patients with atrial fibrillation recurrence showed higher LAC contribution to LV filling (P < 0.0001) and noninvasively estimated left atrial stiffness (P < 0.0001) compared with sinus rhythm patients. There were no other differences, neither in clinical characteristics nor in LV properties. At multivariate LAC (P < 0.001), left atrial stiffness (P = 0.002) and volume (P = 0.043) predicted early atrial fibrillation relapse, even when compared with other confounding factors. Receiver-operating characteristics area (ROC) analysis confirmed LAC as best atrial fibrillation recurrence predictor (0.84, P < 0.0001), cut-off value more than 54% exhibiting reasonable sensibility-specificity (76–75%).

Conclusion
Atrial fibrillation makes LV filling dependent on reciprocation between left atrial reservoir/conduit phases. Our data suggest that LAC larger contribution to filling in persistent atrial fibrillation patients reflects left atrial and LV diastolic dysfunction, which skews atrio-ventricular interaction that leads to atrial fibrillation perpetuation, making LAC a powerful atrial fibrillation recurrence predictor after ECV.
Transcathether aortic valve implantation with the new repositionable self-expandable Medtronic Evolut R vs. CoreValve system: evidence on the benefit of a meta-analytical approach
Authors: Kowalewski Mariusz , Gozdek Mirosław , Raffa Giuseppe Maria , Słomka Artur , Zieliński Kamil , Kubica Jacek , Anisimowicz Lech , Kowalewski Janusz , Landes Uri , Kornowski Ran , Lorusso Roberto , Suwalski Piotr 
Published: March 2019

Aims
To compare transcatheter aortic valve replacement TAVR with self-expandable first-generation Medtronic CoreValve with new-generation Evolut R devices in patients with aortic stenosis.

Methods
Multiple databases were screened for all available reports directly or indirectly comparing CoreValve vs Evolut R. Primary endpoint was device success. Procedural, functional and clinical outcomes were assessed as well.

Results
Ten retrospective series including 12 294 pts. were found. Overall device success rate was 95.5% and was statistically higher in the Evolut R treated patients as compared with CoreValve: 96.6 vs. 94.8%, respectively; RR (risk ratio) 95%CIs (confidence intervals): 1.02 (1.00-1.04); P = 0.01. There were no statistical differences with regard to postoperative mean aortic gradients 8.5 +/- 5.3 vs 7.9 +/- 4.6 with Evolut R and CoreValve. Evolut R valve demonstrated nearly 50% reduction of the risk for moderate-to-severe paravalvilar leak 0.55 (0.39-0.79); P = 0.001; 60% statistically significant lower risk of developing myocardial injury 0.40 (0.22-0.72); P = 0.002 and numerical reductions in the risk of acute kidney injury, vascular complications and bleeding. Together with significantly reduced risk of permanent pacemaker implantation (0.80 [0.67-0.96]; P = 0.02) the above benefits were associated with 40% reduction in the risk of 30-day all-cause mortality with Evolut R as compared to CoreValve: 0.60 (0.37-1.00); P = 0.05.

Conclusions
The use of new-generation Evolut R was associated with improved procedural, functional and clinical outcomes compared with the CoreValve device.
Meta-analysis of impact of liver disease on mortality after transcatheter aortic valve implantation
Authors: Takagi Hisato , Hari Yosuke , Kawai Norikazu , Kuno Toshiki , Ando Tomo 
Published: March 2019

Aims
To evaluate whether liver disease is associated with increased mortality after transcatheter aortic valve implantation (TAVI) and whether TAVI is associated with decreased mortality compared to surgical aortic valve replacement (SAVR) in patients with liver disease, we performed meta-analyses of currently available studies.

Methods
Studies reporting mortality in TAVI patients with liver disease versus those without liver disease and mortality after TAVI versus SAVR in patients with liver disease were eligible to be included. A relative risk (RR) or hazard ratio of mortality for TAVI patients with versus without liver disease and mortality for TAVI versus SAVR in patients with liver disease was extracted from each individual study. Study-specific estimates were combined in the random-effects model.

Results
We identified nine studies of TAVI patients with versus without liver disease and four studies of TAVI versus SAVR in patients with liver cirrhosis. Pooled analyses demonstrated no association of liver disease with early (in-hospital/30-day) mortality (P = 0.28), but a statistically significant association of liver disease with increases mid-term (1–2-year) mortality (hazard ratio 1.87, P < 0.00001) in TAVI patients, and no statistically significant difference in in-hospital mortality between TAVI and SAVR in patients with cirrhosis (RR 0.60, P = 0.12).

Conclusion
There may be no impact of liver disease on early mortality in TAVI patients, negative impact of liver disease on mid-term mortality in TAVI patients, and no difference in in-hospital mortality between TAVI and SAVR in patients with liver cirrhosis.
Bilateral left lateral ridge ablation increases the long-term success of patients ablated for atrial fibrillation
Authors: Di Monaco Antonio , Quadrini Federico , Troisi Federica , Vitulano Nicola , Cecere Giacomo , Guida Pietro , Langialonga Tommaso , Grimaldi Massimo 
Published: March 2019

AimsPulmonary vein isolation (PVI) is the cornerstone of catheter ablation in paroxysmal atrial fibrillation (PAF). Studies reported that the PVI single procedure was able to achieve durable sinus rhythm without the need of antiarrhythmic drugs in 60–80% of patients with PAF. In this study, we report data regarding bilateral left lateral ridge ablation for PAF.MethodsWe retrospectively collected data of 120 consecutive patients (mean age 56 ± 10 years; 62% male) referred to our center to perform PVI. In 60 patients we performed PVI (group 1) and in 60 patients performed PVI and bilateral left lateral ridge ablation (group 2). All patients performed a clinical follow-up after 24 months from the ablation procedure.ResultsPVI was achieved in all patients. The mean radiofrequency time to perform ablation on the left atrial appendage ostium was 216 ± 49 s. In all patients of group 2 we obtained disappearance of local electrograms and the loss of local capture during pacing on posterior wall of left atrial appendage ridge. No significant differences were found between the two groups regarding mean contact force during ablation (14 ± 4 vs. 15 ± 4 g; groups 1 and 2, respectively,P = 0.34). At 24-month follow-up, single procedure success rate was significantly higher in group 2 compared with group 1 (88 vs. 74%, respectively;P = 0.03). No significant procedural complications were documented.ConclusionBilateral left lateral ridge ablation is a safe technique able to improve the success rate of PVI in patients with PAF.
The Corelation between Labour Market and Education – Results of a Comparative Study Conducted in the Hungarian, Romanian and British Educational Systems
Authors: Máthé Ilona 
Published: March 2019

Abstract
The present study aims at highlighting some of the impacts that labour market an education mutually have on each other both in the context of economies in transition (even if they used to have long historic traditions related to pioneering in instruction and education at mass and elite level) and that of a steady and consequent capitalist state undisturbed by the storms of radical political changes and periods of totally negating the values and results created by former historic eras and communities.
The main idea is that the relationship between the labour market and education is that of a mutual demand and supply based corelation, permanently influencing each other, so no political or economic authority and power should miss taking this into consideration unless they want to fail.