bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expansion of pharmacist clinical services to optimize the management of immune checkpoint inhibitor toxicities
Authors: Renna Catherine E , Dow Elizabeth N , Bergsbaken Jason J , Leal Ticiana A 
Published: April 2019

Introduction The development of immune checkpoint inhibitors has revolutionized cancer treatment and is now a part of the treatment paradigm for several malignancies. Although immune checkpoint inhibitors are generally well tolerated, treatment is associated with immune-related adverse events, some serious and potentially life threatening. Early identification and prompt appropriate management of immune-related adverse events are crucial to prevent morbidity and mortality. The complexity and severity of immune-related adverse events require interdisciplinary collaboration to optimize care. Patient and caregiver education and continued communication between patients and members of the oncology care team are vital for timely recognition and successful management of immune-related adverse events. The objective of this program is to provide a proof of concept; a pharmacist-led immune checkpoint inhibitor management program will increase early recognition and management of immune-related adverse events through patient and caregiver education and proactively assessing patients for toxicities. Methods At the University of Wisconsin Carbone Cancer Center, we developed and implemented a pharmacist-driven program, referred to as the immune checkpoint inhibitor program, which aimed to ensure patient and caregiver education and continuous monitoring of immune-related adverse events. This program utilized pharmacist–patient encounters to improve patient and caregiver education and follow-up monitoring. The design and implementation are detailed. Pharmacist interventions and patient outcomes were evaluated. Results At interim analysis, 47 patients were enrolled in the program and pharmacists completed 34 interventions on 26 patients. Pharmacists are well positioned to educate patients and caregivers on immune checkpoint inhibitor therapy and provide proactive monitoring to detect immune-related adverse events. We hypothesize that the interventions made by pharmacist may lead to earlier recognition and treatment of immune-related adverse events.
Options for end stage vascular access: Translumbar catheter, arterial-arterial access or right atrial graft?
Authors: Inston Nicholas , Khawaja Aurangzaib , Mistry Hiren , Jones Robert , Valenti Domenico 
Published: April 2019

Background: Running out of vascular access for dialysis is thankfully rare, but despite this, most units will have a number of patients with few options and in a precarious state. The increasing longevity of dialysis patients portends more patients will reach minimal access options. End stage vascular access is poorly defined but classification may enable assessment and comparison of treatment options. Three options for patients with end stage access are a central venous catheter through a translumbar or transhepatic route, arterial-arterial prosthetic loop or a right atrial graft. Aims: The aims of this study are to provide a structured review of evidence for these procedures to allow application and guide practice for patients with end stage vascular access. Methods: A standardised search of published literature was performed of relevant studies. In addition, the references cited in those papers were assessed for any further available articles. All study types were included and reviewed by two authors independently. Primary outcomes were patient survival and secondary patency rate at 3 and 12 months. Secondary outcomes were long-term patency rates, mean time to cannulation and complications such as access dysfunction, thrombosis and infection. Summary: Based on the available evidence, it would appear that arterial-arterial prosthetic loop is a definitive option for maintaining dialysis access in patients with no more arteriovenous access options. Translumbar and transhepatic dialysis catheters may offer short- and medium-term options and right atrial grafts may also be suitable as an option where arterial-arterial prosthetic loop is unsuitable.
Comparing PTSD treatment retention among survivors of military sexual trauma utilizing clinical video technology and in-person approaches
Authors: Valentine Lisa M , Donofry Shannon D , Broman Rachel B , Smith Erin R , Rauch Sheila AM , Sexton Minden B 
Published: April 2019

Introduction Interventions such as Prolonged Exposure (PE) and Cognitive Processing Therapy (CPT) have demonstrated efficacy for the treatment of post-traumatic stress disorder (PTSD) following military sexual trauma (MST). However, MST survivors report a number of logistical and social barriers that impede treatment engagement. In an effort to address these barriers, the Veterans Health Administration offers remote delivery of services using clinical video technology (CVT). Evidence suggests PE and CPT can be delivered effectively via CVT. However, it is unclear whether rates of veteran retention in PTSD treatment for MST delivered remotely is comparable to in-person delivery in standard care. Methods Data were drawn from veterans ( N = 171, 18.1% CVT-enrolled) with PTSD following MST who were engaged in either PE or CPT delivered either via CVT or in person. Veterans chose their preferred treatment modality and delivery format in collaboration with providers. Data were analysed to evaluate full completion (FP) of the protocol and completion of a minimally adequate care (MAC) number of sessions. Results FP treatment completion rates did not differ significantly by treatment delivery format. When evaluating receipt of MAC care, CVT utilizers were significantly less likely to complete. Kaplan–Meier analyses of both survival periods detected significant differences in attrition speed, with the CVT group having higher per-session attrition earlier in treatment. Discussion Disengagement from CVT-delivered treatment generally coincided with early imaginal exposures and writing of trauma narratives. CVT providers may have to take special care to develop rapport and problem-solve anticipated barriers to completion to retain survivors in effective trauma-focused interventions.
An unusual case of a giant extracranial vertebral artery aneurysm
Authors: Suliman Abd Elaziz A , Hamid Hytham KS , Mekki Salwa O 
Published: April 2019

Objective Extracranial vertebral artery (VA) aneurysms are rare and are often post-traumatic secondary to penetrating or blunt injuries. Primary extracranial VA aneurysms are far less common. Most of these lesions are located in the proximal (V1) and middle (V2) segments of the VA. Method We report an extremely rare case of a giant aneurysm of the extracranial vertebral artery in a 50-year-old woman who presented with a right posterior neck swelling, headache and pain at the site of the mass. Angiography confirmed aneurysm of V3 segment of the right VA. Treatment included ligation of the artery and aneurysmectomy. Result Magnetic resonance angiography at 12 months showed obliterated proximal segment of the right VA with no obvious flow distally. Conclusion Aneurysms of the extracranial VA are clinically relevant because of the associated risks of rupture and distal embolization. For patients with rupture, pending rupture or a significant mass effect due to a giant lesion, surgery is the treatment modality of choice to attain symptomatic relief.
Prevalence of pulmonary arterial hypertension in the Colombian Caribbean
Authors: Miranda‐Machado Pablo , Baños‐Alvarez Ivan , Alvarez‐Barrios Alvaro 
Published: April 2019

In Latin America, there are no specific data on the prevalence of pulmonary arterial hypertension (PAH). For this reason, the Registro Latinoamericano de Hipertensión Pulmonar (RELAHP) is under development. The aim of this study is to estimate the prevalence of PAH in the Colombian Caribbean in 2015 based on data from a private health insurance company (PHIC) with coverage in that region. All the Individual Service Delivery Registries (RIPS) of all ambulatory care centers that serve the population of the Colombian Caribbean region affiliated with a PHIC selected for this research were reviewed. All patients who had a diagnosis of pulmonary hypertension (PH) were included (International Classification Diseases 10‐Revision [ICD‐10 I270, I272, I278, and I279]). Subsequently, the information on electronic medical records was reviewed. To estimate the prevalence of PAH, the total population of the PHIC and population projections of Colombian Caribbean by Departamento Administrativo Nacional de Estadisticas (DANE) was used. We identified 27 patients with a confirmed diagnosis of PH and 18 patients with a confirmed diagnosis of PAH. Taking into account the total population affiliated to the Caribbean Regional of the PHIC selected for the study in September 2015, a PAH prevalence of approximately 28 cases per million inhabitants is estimated. The mean of age was 22 ± 21.4 years (14.8% children) and 17 (62.9%) were girls/women. The majority of patients presented with PAH (Group 1) (66.6%). The estimated number of cases of PH in Colombian Caribbean in 2015 is approximately 292 cases or 1 in 35,760. Epidemiological estimates of PAH in the Colombian Caribbean are compatible with the definition of orphan or rare diseases. The majority of patients are female.
Subjective Evaluation of Denture Adhesives: A Multicenter Randomized Controlled Trial
Authors: Ohwada G. , Minakuchi S. , Sato Y. , Kondo H. , Nomura T. , Tsuboi A. , Hong G. , Itoh Y. , Kawai Y. , Kimoto S. , Gunji A. , Suzuki A. , Suzuki T. , Kimoto K. , Hoshi N. , Saita M. , Yoneyama Y. , Sato Y. , Morokuma M. , Okazaki J. , Maeda T. , Nakai K. , Ichikawa T. , Nagao K. , Fujimoto K. , Murata H. , Kurogi T. , Yoshida K. , Nishimura M. , Nishi Y. , Murakami M. , Hosoi T. , Hamada T. 
Published: April 2019

Introduction: Many reports show that denture adhesives improve the retention and stability of dentures. However, few randomized controlled trials have examined the effects of denture adhesives. Objective: This 10-center randomized controlled trial with parallel groups involving 200 edentulous patients wearing complete dentures aimed to evaluate the effects of short-term use of cream and powder denture adhesives. Methods: Patients were allocated into 2 cream- and powder-type adhesive groups and 1 control group. Intervention groups were treated with the 2 adhesives (1 each), and the control group received saline solution. Adhesive or control was applied to the denture-mucosal surface for 4 d, and data at baseline and after day 4 of intervention (i.e., 8 meals) were obtained. Patient satisfaction was evaluated with a 100-mm visual analog scale. Oral health–related quality of life was measured with the Japanese version of the Oral Health Impact Profile for Edentulous Patients. Perceived chewing ability was evaluated by a questionnaire regarding ease of chewing and swallowing food. Between-group comparisons were performed with Kruskal-Wallis tests with the Mann-Whitney U test adjusted by Bonferroni correction. Within-group comparisons of pre- and postintervention measurements were performed with the Wilcoxon signed-rank test. Intention-to-treat analysis was also performed. Results: Between-group comparisons showed no significant differences for general satisfaction or Oral Health Impact Profile for Edentulous Patients. However, significant differences in satisfaction with various denture functions with cream- and powder-type adhesives were seen in pre- and postintervention comparisons ( P < 0.05). Significant differences were also observed for perceived chewing ability of hard foods ( P < 0.05). Conclusion: These results suggest that although denture adhesives do not invariably improve denture function, they do affect subjective evaluations and possibly chewing of hard foods. Therefore, the effects of denture adhesive use are insufficient to resolve any fundamental dissatisfaction with dentures ( ClinicalTrials.gov NCT01712802 ). Knowledge Transfer Statement: The results of this study suggest that denture adhesives should be applied under certain conditions; however, an appropriate diagnosis is important before application. These practice-based data provide information to establish evidence-based guidelines for applying denture adhesives.
Twinning and incommensurate modulation in baumoite, Ba0.5[(UO2)3O8Mo2(OH)3](H2O)~3, the first natural Ba uranyl molybdate
Authors: Elliott Peter , Plášil Jakub , Petříček Václav , Čejka Jiří , Bindi Luca 
Published: April 2019

ABSTRACTBaumoite, Ba0.5[(UO2)3O8Mo2(OH)3](H2O)~3, is a new mineral found near Radium Hill, South Australia, where it occurs in a granite matrix associated with baryte, metatorbernite, phurcalite and kaolinite. Baumoite forms thin crusts of yellow to orange–yellow tabular to prismatic crystals. The mineral is translucent with a vitreous lustre and pale yellow streak. Crystals are brittle, the fracture is uneven and show one excellent cleavage. The Mohs hardness is ~2½. The calculated density is 4.61 g/cm3. Optically, baumoite crystals are biaxial (–), with α = 1.716(4), β = 1.761(4), γ = 1.767(4) (white light); and 2Vcalc= 42.2°. Electron microprobe analyses gave the empirical formula Ba0.87Ca0.03Al0.04U2.97Mo2.02P0.03O22H11.99, based on 22 O atoms per formula unit. The eight strongest lines in the powder X-ray diffraction pattern are [dobsÅ (I) (hkl)]: 9.175(39)(12${\bar 1}$), 7.450(100)(020), 3.554(20)(221), 3.365(31)(004, 202), 3.255(31)(123, 30${\bar 2}$), 3.209(28)(12${\bar 4}$), 3.067(33)(30${\bar 3}$, 222, 32${\bar 2}$) and 2.977(20)(142). Single-crystal X-ray studies (R1= 5.85% for 1892 main reflections) indicate that baumoite is monoclinic, superspace groupX2/m(a0g)0swithX= (0,½,0,½), with unit-cell parameters:a= 9.8337(3),b= 15.0436(5),c= 14.2055(6) Å, β = 108.978(3)°,V= 1987.25(13) Å3andZ= 4. The crystal structure is twinned and incommensurately modulated and is based upon sheets of U6+and Mo6+polyhedra of unique topology. Four independent cationic sites partially occupied by Ba atoms are located between the sheets, together with H2O molecules.
Non-Hodgkin Lymphoma in the Middle East Is Characterized by Low Incidence Rates With Advancing Age
Authors: Yaqo Rafil T. , Jalal Sana D. , Ghafour Kharaman J. , Hassan Hemin A. , Hughson Michael D. 
Published: April 2019

PURPOSE In the Middle East, incidence rate ratios (IRRs) of non-Hodgkin lymphoma (NHL) to Hodgkin lymphoma (HL) are more than 50% lower than the United States. MATERIALS AND METHODS Age-specific incidence rates (ASIRs), age-adjusted incidence rates (AAIRs), and IRRs of NHL:HL were compared using the cancer registries of Iraq, Jordan, Saudi Arabia, and US SEER. RESULTS The NHL AAIR (95% CI) per 100,000 population was 4.4 (4.1 to 4.7) for Iraq, 5.4 (4.6 to 6.2) for Jordan, 4.7 (4.4 to 5.1) for Saudi Arabia, and 13.2 (13.0 to 13.4) for the United States. The HL AAIR was 1.8 (1.6 to 2.0) for Iraq, 1.8 (1.4 to 2.2) for Jordan, 2.1 (1.9 to 2.2) for Saudi Arabia, and 2.3 (2.2 to 2.4) for the United States, with respective NHL:HL IRR of 2.4 (2.2 to 2.7), 3.0 (2.4 to 3.8), 2.2 (2.0 to 2.5), and 5.7 (5.5 to 6.0). NHL ASIRs for the Middle East and the United States were similar until 30 to 39 years of age. Thereafter, ASIR of NHL peaked at 20 to 33 per 100,000 at age 70 years in the Middle East regions, all much lower than the US age 70 years rate of greater than 100 per 100,000. Diffuse large B-cell lymphoma (DLBCL) represented 52% of NHL in Sulaimaniyah Province of Iraq and 51% of NHL in Saudi Arabia. Both regions had AAIR for DLBCL less than 42% of DLBCL in US SEER. Pediatric Epstein-Barr virus–related Burkitt’s lymphoma at 8% was the second most frequent NHL in Sulaimaniyah but made little contribution to overall NHL rates. CONCLUSION The incidence of HL was slightly lower than in the United States, but it was the markedly lower rates of adult NHL with advancing age, including the predominant DLBCL, that accounted for the low NHL:HL IRR in these Middle Eastern countries.
Plasma Steroid Profiles in Subclinical Compared With Overt Adrenal Cushing Syndrome
Authors: Masjkur Jimmy , Gruber Matthias , Peitzsch Mirko , Kaden Denise , Di Dalmazi Guido , Bidlingmaier Martin , Zopp Stephanie , Langton Katharina , Fazel Julia , Beuschlein Felix , Bornstein Stefan Richard , Reincke Martin , Eisenhofer Graeme 
Published: April 2019

Abstract

Context
Diagnosis of subclinical adrenal hypercortisolism is based on several tests of the hypothalamic-pituitary-adrenal axis to establish mild alterations of cortisol secretion and dysregulated cortisol physiology.

Objective
We assessed whether plasma steroid profiles might assist diagnosis of subclinical Cushing syndrome (SC).

Design
Retrospective cross-sectional study.

Setting
Two tertiary medical centers.

Patients
Of 208 patients tested for hypercortisolism, disease was excluded in 152 and confirmed in 21 with overt adrenal Cushing syndrome (AC) compared to 35 with SC. Another 277 age- and sex-matched hypertensive and normotensive volunteers were included for reference.

Main Outcome Measures
A panel of 15 plasma steroids was measured by mass spectrometry, with classification by discriminant analysis.

Results
Patients with SC had lower plasma concentrations of dehydroepiandrosterone and dehydroepiandrosterone-sulfate than subjects without SC (P < 0.05). The largest increases (P < 0.001) in plasma steroids among patients with SC were observed for 11-deoxycortisol and 11-deoxycorticosterone. Nevertheless, concentrations of 11-deoxycorticosterone, 11-deoxycortisol, and pregnenolone in patients with AC were higher (P < 0.05) than in those with SC. Patients with SC or AC could be distinguished from subjects without disease using this combination of steroids as precisely as with use of measurements of serum cortisol after administration of dexamethasone. The steroid combination provided superior diagnostic performance compared with each of the other routine biochemical tests.

Conclusion
Distinct plasma steroid profiles in patients with SC may provide a simple and reliable screening method for establishing the diagnosis.
Ethical dilemmas in orthodontics
Authors: Burns Angus J , Noar Joseph H 
Published: April 2019

Those practising orthodontics frequently face ethical dilemmas. This article seeks to explore dilemmas, which the authors consider arise often in the field of orthodontics. The emphasis is on best practice, evidence-based practice and prioritizing patients' interests. CPD/Clinical Relevance: The intention of this article is to encourage thought and debate regarding everyday orthodontic decision-making.
Pernikahan Transnasional Versus Perdagangan Perempuan (Book Review)
Authors: Ismahfudi Ismahfudi 
Published: April 2019

Judul Buku : Politik Perdagangan PerempuanPenulis : Andy YentriyaniPengantar : Mely G. TanPenerbit : Galang Press, YogyakartaTahun Terbit : 2004Tebal: 251 Halaman + xviii
Kaum Perempuan Dalam Cengkraman Hegemoni Budaya Patriarkhi (Book Review)
Authors: Rafiqoh Aunur 
Published: April 2019

Judul Buku : Al,Mar'ah Baina as,Syariah Wa al,HayatPenulis : Dr. Muhammad al-HabsyiVolume : 17 6 halamanCetakan : Cet ke-3 Tahun 2002.E-mail : hbshco@net.syWebsite : www.alzahraa.org
Prognostic value of involved/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients
Authors: Henriot Basile , Rouger Emmanuel , Rousseau Chloé , Escoffre Martine , Sébillot Martine , Bendavid Claude , Minvielle Stéphane , Avet-Loiseau Hervé , Decaux Olivier , Moreau Caroline 
Published: April 2019

Abstract

Background
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder with a high risk of progression to symptomatic multiple myeloma (MM). The serum free light chain (sFLC) ratio is a powerful prognostic factor for SMM: an sFLC ratio ≥8 has been reported to be associated with a high risk of progression to MM, and an sFLC ratio ≥100 has been described as a criterion for ultra-high-risk SMM, and has been integrated into the definition criteria for MM since 2014. However, all recommendations were based on sFLC measured using the first commercialized assay, Freelite™, while other assays are now available. We aimed to evaluate the safety and accuracy of N-Latex sFLC to identify high-risk and ultra-high-risk SMM.

Methods
The sFLC ratio was measured at diagnosis with both Freelite and N-Latex assays in a cohort of 176 SMM patients on a BN Prospec nephelometer. Demographic, clinical, therapeutic and laboratory data were collected at the time of diagnosis and at follow-up.

Results
Sixty-two patients (35.2%) progressed to MM within 2 years. Compared to Freelite™ sFLC, N Latex sFLC ratios ≥8 and ≥100 provided similar performances for the identification of high-risk and ultra-high risk SMM patients.

Conclusions
Our results evidenced that the N-Latex assay could be used for SMM monitoring, like Freelite. However, an N-Latex sFLC ratio ≥70 appears to provide similar performances to a Freelite sFLC ratio ≥100, with a slightly better positive predictive value. Both assays provided accurate identification of high-risk and ultra-high risk SMM patients. These results should be confirmed in an independent study.
Shifting tenses, viewpoints, and the nature of narrative communication
Authors: Verhagen Arie 
Published: April 2019

AbstractThis paper first develops a theoretically motivated view of narrative as a special form of inferential, cooperative human communication, of the role that the past tense plays in the intersubjective coordination of narrators and readers, viz. that of ‘curtailing’ the immediate argumentative applicability of the represented situation, and of its relation to viewpoint management. In three case studies, it is subsequently shown how this helps to elucidate certain effects of present and past tense alternations in stories. While these effects are multi-faceted and highly text-specific, there is a common denominator of the use of the past tense in the dimension of narrator-reader communication in the narratives. The analysis supports an independently motivated conception of intersubjectivity that assigns a special status to ‘coordination with other minds’, apart from senders and addressees.
Some remarks on the Dirichlet problem on infinite trees
Authors: Chalmoukis Nikolaos , Levi Matteo 
Published: April 2019

Abstract
We consider the Dirichlet problem on in_nite and locally _nite rooted trees, andwe prove that the set of irregular points for continuous data has zero capacity. We also give some uniqueness results for solutions in Sobolev W1,p of the tree.
Creative Entrepreneurs’ Well-Being, Opportunity Recognition and Absorptive Capacity: Self-Determination Theory Perspective
Authors: Chen Ming-Huei , Tseng Min , Teng Min-Jun 
Published: April 2019

AbstractRecognizing the right opportunities is a key capability in the entrepreneurial process, and creative entrepreneurs’ well-being at work can strengthen their inherent motivation to absorb external knowledge for desirable outcomes. Well-being at work is pleasant judgments of positive attitudes or pleasant experiences, but previous research mainly regarded well-being as an outcome variable. Therefore, this study considers the role of well-being as a mediator conceptualized in physical, psychological, and social well-being dimensions in the opportunity recognition process. Based upon the self-determination theory, this study examines how creative entrepreneurs’ motivation, including creative thinking, self-efficacy, and relatedness, influences their well-being and further affects opportunity recognition. Results from a sample of 234 creative entrepreneurs in Taiwan show that well-being positively mediates the effect of relatedness on opportunity recognition capabilities and absorptive capacity. Moreover, creative thinking and self-efficacy are associated with relatedness, and further with well-being. The key findings suggest that well-being plays a critical role to stimulate motivation for further capability building. This study extends the self-determination theory by linking entrepreneurial motivation with well-being in the entrepreneurial opportunity seeking process.