bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Ultrasound-Guided Gastrocnemius Injection With Botulinum Toxin for Chronic Plantar Fasciitis
Authors: Abbasian Mohammadreza , Baghbani Salar , Barangi Samira , Fairhurst Paul Gilbert , Ebrahimpour Adel , Krause Fabian , Hashemi Masoud 
Published: October 2019

Background: The objective of this study was to determine whether the injection of botulinum toxin A (BTA) in the medial head of the gastrocnemius muscle could yield improvements in function and disability in patients with chronic plantar fasciitis with follow-up 12 months after treatment. Methods: Thirty-two patients with chronic plantar fasciitis were included in the study and randomly allocated to the BTA and placebo groups. The visual analog scale (VAS) and American Orthopaedic Foot & Ankle Society (AOFAS) scores were used to evaluate pain levels pre- and postinjection as well as function of the foot, respectively. Patients were also asked to rate their treatment satisfaction 1 year after injection. The range of dorsiflexion was measured before and 12 months after the injection. Results: At the 12-month follow-up, the mean VAS decreased from 7.8 to 4 in the placebo group and from 8 to 0.33 in the BTA group. Furthermore, the mean AOFAS scores increased from 48.4 to 65.3 in the placebo group and from 45.5 to 90.6 in the BTA group. The postinjection scores in the BTA group were significantly higher than those in the placebo group ( P < .001). Patient satisfaction in the BTA group was higher than that in the placebo group at the 12-month follow-up. Conclusion: In patients with chronic plantar fasciitis, the use of BTA had a positive effect on improvement in pain and foot function 1 year after treatment. Level of Evidence: Level I, prospective randomized controlled trial.
Comparison between protocols and publications for prognostic and predictive cancer biomarker studies
Authors: Doussau Adelaide , Vinarov Esther , Barsanti-Innes Brianna , Kimmelman Jonathan 
Published: October 2019

Background: Method prespecification in study protocols is important for controlling bias in reports. The primary goal of this study was to assess potential for discordance between study protocols and publications reporting predictive or prognostic cancer biomarker research. Secondary objectives included comparing characteristics of publications with accessible protocols compared to those without. Methods: Publications reporting predictive or prognostic cancer biomarker research were identified from 15 major journals, 2012–2015. Protocols were sought online or through repeated queries of corresponding authors. The following four items were extracted: (1) biomarkers, (2) biospecimen/assays, (3) sample size, (4) endpoints. We defined “explicit discordance” as the presence of major inconsistencies on these items. Results: Of 149 eligible publications, we obtained 19 eligible protocols online (13%). Out of a random sample of 103 publications where protocols were not available online, 12 protocols (12%) were furnished by corresponding authors; 8 (8% of authors) explicitly stated the absence of a protocol. Among 24 retrospective cohort studies, no protocol could be accessed. We found explicit discordance between publications and protocols for 18 studies (58%), in particular choice of biomarkers (36%), biospecimen/assays (6%), or endpoints (29%). Conclusion: Protocols are generally not accessible or not used for cancer biomarker studies. Publications were often explicitly discordant with protocols, particularly regarding biomarkers and endpoints. Our findings point to common unaddressed risk of bias in publications of major journals reporting the relationship between cancer biomarkers and clinical endpoints.
Autologous hematopoietic stem-cell transplant in small-sized and peripheral centers: a 10-year experiment
Authors: Choufi Bachra , Alsuliman Tamim 
Published: October 2019

Background: Along with continuing changes in therapeutic modalities, indications of autologous hematopoietic stem-cell transplantation (ASCT) have been emerging and changing considerably, especially in the era of targeted therapy and small molecule inhibitors. Patients treated with novel agents tend to have a longer survival period, thus eventually reaching higher ages at ASCT. Herein, and to address the question of ASCT outcomes in small, community-based, peripheral French centers, we report the 10-year follow-up results of 136 patients who received ASCT in our eight-bed ASCT unit, situated in an urban area. Methods: We retrospectively analyzed a cohort of 136 patients treated between 2008 and 2017 at the Duchenne Hospital Center. Of these 136 patients, 75 underwent ASCT for myeloma, while 61 underwent ASCT for lymphoma, amongst which 57 patients were treated for B-cell lymphoma. The median age was 65 years (range, 27–72) for myeloma patients, and 62 years (range, 27–71) for patients with lymphoma. Results: The cohort median follow up was estimated at 33 months; 10-year overall survival (OS) and progression-free survival (PFS) were 71% and 64% for B-cell non-Hodgkin lymphoma, and 75% and 45% for myeloma, respectively. No statistically significant differences were found for OS or 1-year PFS between patients who received ASCT from 2008 to 2012, and those who received it from 2013 to 2017. Conclusions: In the absence of randomized trials studying the role of center size, experience, and standardization procedure for ASCT outcome, these results may suggest that ASCT in peripheral accredited small-sized centers could be a viable option to facilitate follow up and enable access to this treatment, especially for elderly patients, in comparison with referring the patient to central large hospitals to undergo ASCT.
The updated PIM-Taiwan criteria: a list of potentially inappropriate medications in older people
Authors: Chang Chirn-Bin , Lai Hsiu-Yun , Hwang Shinn-Jang , Yang Shu-Yu , Wu Ru-Shu , Chang Lo-Yu , Lee I-Shan , Liu Hsing-Cheng , Chan Ding-Cheng 
Published: October 2019

Background: Explicit criteria for potentially inappropriate medications (PIMs) developed for other countries are difficult to apply to a specific territory. This study aimed to update the PIM-Taiwan criteria from a qualitative review of several published PIM criteria, followed by consensus among regional experts in Taiwan. Methods: After a review of the literature, we selected four sets of published PIM criteria to construct preliminary core PIMs. The Beers criteria, Fit fOR The Aged (FORTA), and Japan criteria were used for PIMs, without consideration of chronic diseases. The Beers criteria, Screening Tool of Older Persons’ Prescriptions (STOPP) criteria, and Japan criteria were used for PIMs with respect to chronic diseases. We asked experts ( n = 24) to rate their agreement with each statement, including in the final PIM criteria, after two rounds of modified Delphi methods. The intraclass coefficient (ICC) was used to examine the reliability of the modified Delphi method. Results: Overall, two categories of PIMs were established: 131 individual drugs and 9 drugs with combinations that should generally be avoided; and 9 chronic diseases with their corresponding PIMs that have drug–disease interactions. The ICC estimates for PIMs to be avoided generally were 0.634 and 0.557 (round 1 and 2) and those for PIMs with respect to chronic diseases were 0.866 and 0.775 (round 1 and 2) of the Delphi method, respectively. Conclusions: The 2018 version of PIM-Taiwan criteria was established and several modifications were made to keep the criteria updated and relevant. Clinicians can use them to reduce polypharmacy and PIMs among older patients.
Developmental divergence: motor trajectories in children with fragile X syndrome with and without co-occurring autism
Authors: Will Elizabeth A. , Bishop Somer L. , Roberts Jane E. 
Published: October 2019

Abstract

Background
Autism spectrum disorder (ASD) is highly prevalent in fragile X syndrome (FXS), affecting 50–70% of males. Motor impairments are a shared feature across autism and FXS that may help to better characterize autism in FXS. As motor skills provide a critical foundation for various language, cognitive, and social outcomes, they may serve an important mechanistic role for autism in FXS. As such, this study aimed to identify differences in motor trajectories across direct assessment and parent-report measures of fine and gross motor development between FXS with and without autism, and typical development, while controlling for cognitive functioning.

Methods
This prospective longitudinal study included 42 children with FXS, 24 of whom also had ASD (FXS + ASD), as well as 40 typically developing children. The Mullen Scales of Early Learning provided a direct measure of fine and gross motor skills, and the Vineland Adaptive Behavior Scales provided a measure of parent-reported fine and gross motor skills. Random slopes and random intercepts multilevel models were tested to determine divergence in developmental motor trajectories between groups when controlling for cognitive level.

Results
Model results indicated the children with FXS + ASD diverged from TD children by 9-months on all measures of gross and fine motor skills, even when controlling for cognitive level. Results also indicated an early divergence in motor trajectories of fine and gross motor skills between the FXS + ASD and FXS groups when controlling for cognitive level. This divergence was statistically significant by 18 months, with the FXS + ASD showing decelerated growth in motor skills across direct observation and parent-report measures.

Conclusions
This study is the first to examine longitudinal trends in motor development in children with FXS with and without comorbid ASD using both direct assessment and parent-report measures of fine and gross motor. Furthermore, it is among the first to account for nonverbal cognitive delays, a step towards elucidating the isolated role of motor impairments in FXS with and without ASD. Findings underscore the role of motor impairments as a possible signal representing greater underlying genetic liability, or as a potential catalyst or consequence, of co-occurring autism in FXS.
Behavioural and psychological characteristics in Pitt-Hopkins syndrome: a comparison with Angelman and Cornelia de Lange syndromes
Authors: Watkins Alice , Bissell Stacey , Moss Jo , Oliver Chris , Clayton-Smith Jill , Haye Lorraine , Heald Mary , Welham Alice 
Published: October 2019

AbstractBackgroundPitt-Hopkins syndrome (PTHS) is a genetic neurodevelopmental disorder associated with intellectual disability. Although the genetic mechanisms underlying the disorder have been identified, description of its behavioural phenotype is in its infancy. In this study, reported behavioural and psychological characteristics of individuals with PTHS were investigated in comparison with the reported behaviour of age-matched individuals with Angelman syndrome (AS) and Cornelia de Lange syndrome (CdLS).MethodsQuestionnaire data were collected from parents/caregivers of individuals with PTHS (n = 24), assessing behaviours associated with autism spectrum disorder (ASD), sociability, mood, repetitive behaviour, sensory processing, challenging behaviours and overactivity and impulsivity. For most measures, data were compared to data for people with AS (n = 24) and CdLS (n = 24) individually matched by adaptive ability, age and sex.ResultsIndividuals with PTHS evidenced significantly higher levels of difficulties with social communication and reciprocal social interaction than individuals with AS, with 21 of 22 participants with PTHS meeting criteria indicative of ASD on a screening instrument. Individuals with PTHS were reported to be less sociable with familiar and unfamiliar people than individuals with AS, but more sociable with unfamiliar people than individuals with CdLS. Data also suggested areas of atypicality in sensory experiences. Challenging behaviours were reported frequently in PTHS, with self-injury (70.8%) occurring at significantly higher rates than in AS (41.7%) and aggression (54.2%) occurring at significantly higher rates than in CdLS (25%). Individuals with PTHS also evidenced lower reported mood than individuals with AS.ConclusionsBehaviours which may be characteristic of PTHS include those associated with ASD, including deficits in social communication and reciprocal social interaction. High rates of aggression and self-injurious behaviour compared to other genetic syndrome groups are of potential clinical significance and warrant further investigation. An atypical sensory profile may also be evident in PTHS. The specific aetiology of and relationships between different behavioural and psychological atypicalities in PTHS, and effective clinical management of these, present potential topics for future research.
Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures
Authors: Lundgren Julie R. , Færch Kristine , Witte Daniel R. , Jonsson Anna E. , Pedersen Oluf , Hansen Torben , Lauritzen Torsten , Holst Jens J. , Vistisen Dorte , Jørgensen Marit E. , Torekov Signe S. , Johansen Nanna B. 
Published: October 2019

Abstract
Background and aim
Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with decreases in blood pressure and CVD risk. Our aim was to investigate the association between endogenous GLP-1 responses to oral glucose and peripheral and central haemodynamic measures in a population at risk of diabetes and CVD.

Methods
This cross-sectional study included 837 Danish individuals from the ADDITION-PRO cohort (52% men, median (interquartile range) age 65.5 (59.8 to 70.7) years, BMI 26.1 (23.4 to 28.5) kg/m2, without antihypertensive treatment and known diabetes). All participants received an oral glucose tolerance test with measurements of GLP-1 at 0, 30 and 120 min. Aortic stiffness was assessed by pulse wave velocity (PWV). The associations between GLP-1 response and central and brachial blood pressure (BP) and PWV were assessed in linear regression models adjusting for age and sex.

Results
A greater GLP-1 response was associated with lower central systolic and diastolic BP of − 1.17 mmHg (95% confidence interval (CI) − 2.07 to − 0.27 mmHg, P = 0.011) and − 0.74 mmHg (95% CI − 1.29 to − 0.18 mmHg, P = 0.009), respectively, as well as lower brachial systolic and diastolic BP of − 1.27 mmHg (95% CI − 2.20 to − 0.33 mmHg, P = 0.008) and − 1.00 (95% CI − 1.56 to − 0.44 mmHg, P = 0.001), respectively. PWV was not associated with GLP-1 release (P = 0.3). Individuals with the greatest quartile of GLP-1 response had clinically relevant lower BP measures compared to individuals with the lowest quartile of GLP-1 response (central systolic BP: − 4.94 (95% CI − 8.56 to − 1.31) mmHg, central diastolic BP: − 3.05 (95% CI − 5.29 to − 0.80) mmHg, brachial systolic BP: − 5.18 (95% CI − 8.94 to − 1.42) mmHg, and brachial diastolic BP: − 2.96 (95% CI − 5.26 to − 0.67) mmHg).

Conclusion
Greater glucose-stimulated GLP-1 responses were associated with clinically relevant lower central and peripheral blood pressures, consistent with beneficial effects on the cardiovascular system and reduced risk of CVD and mortality.
Trial registration ClinicalTrials.gov Identifier: NCT00237549. Retrospectively registered 10 October 2005
Event-specific multiplex PCR method for four genetically modified cotton varieties, and its application
Authors: Eum Soon-Jae , Kim Il Ryong , Lim Hye Song , Lee Jung Ro , Choi Wonkyun 
Published: October 2019

Abstract
Multiplex polymerase chain reaction (PCR) methods have been developed and validated for screening, tracing, and regulating genetically modified (GM) crops in quarantine and environmental monitoring. In this study, we aimed to develop a method to simultaneously detect four GM cotton varieties in order to establish a screening system for cotton volunteers. Based on the sequence of DNA in the junction between introduced gene and flanking genomic DNA of four GM cotton events, herbicide-tolerant MON88701 and DAS-81910-7 and insect-resistant COT102 and T304-40, event-specific primers were designed and a multiplex detection method was developed. The simplex PCR results supported the multiplex PCR results; the amplification efficiency of the novel multiplex PCR method was increased compared with that of the Joint Research Centre (JRC) method. Based on the accuracy and efficiency, the method can be applied to detect and identify randomly mixed reference materials and suspected cotton volunteers. To apply this multiplex PCR method to living modified (LM) environmental monitoring samples, we performed additional PCR analysis to identify whether the volunteers were the four LM cotton varieties. As a result, 66 cotton volunteers were identified with stack event, comprising one or two of the four LM cotton events, and all stacks have been approved in South Korea for food, feed, and processing. These results indicated that our novel multiplex method is suitable for LMO identification.
A sliding mode contact electrification based triboelectric-electromagnetic hybrid generator for small-scale biomechanical energy harvesting
Authors: Vivekananthan Venkateswaran , Kim Woo Joong , Alluri Nagamalleswara Rao , Purusothaman Yuvasree , Abisegapriyan K. S. , Kim Sang-Jae 
Published: October 2019

Abstract
The present work describes the hybridization of two different energy harvesters works simultaneously in a single package. By applying simultaneous mechanical force, two components such as triboelectric nanogenerator (TENG) and electromagnetic generator (EMG) independently produce power. The hybrid device was made with a polymeric cylinder composed of Kapton in the inner wall; a copper coil wound outside the cylinder and neodymium magnet and small bits of paper housed inside it. The paper flakes having the dimension of 5 mm × 5 mm, which are triboelectric positive slides over the negative triboelectric layer Kapton. The potential difference between the two different triboelectric material leads to the generation of electric power. The triboelectric component generates the maximum output with the voltage of ≈ 20 V and the current of 300 nA. The magnet inside the cylinder moves simultaneously along with the paper made the production of electric flux in the coil. The alternating magnetic flux induces the current in the outer coil as per the Lenz’s law. The maximum output generated from the EMG component with the obtained voltage of 2 V and the maximum current of 10 mA. Further, to analyze the actual working behavior of the device, commercial capacitor charging behavior was analyzed. The TENG component runs the consistent charging behavior, whereas the EMG component offers a rapid charging behavior, under hybrid mode both the merits can be utilized. The device has had placed in a backpack, and the biomechanical energy from human motions such as walking, running and jumping had been demonstrated. This study confirms that the proposed hybrid generator is capable of powering small electronic devices such as global positioning system (GPS), flashlights and potentially be able to use as an active MEMS/NEMS-based self-powered sensor.
Big data analysis and distributed deep learning for next-generation intrusion detection system optimization
Authors: Al Jallad Khloud , Aljnidi Mohamad , Desouki Mohammad Said 
Published: October 2019

AbstractWith the growing use of information technology in all life domains, hacking has become more negatively effective than ever before. Also with developing technologies, attacks numbers are growing exponentially every few months and become more sophisticated so that traditional IDS becomes inefficient detecting them. This paper proposes a solution to detect not only new threats with higher detection rate and lower false positive than already used IDS, but also it could detect collective and contextual security attacks. We achieve those results by using Networking Chatbot, a deep recurrent neural network: Long Short Term Memory (LSTM) on top of Apache Spark Framework that has an input of flow traffic and traffic aggregation and the output is a language of two words, normal or abnormal. We propose merging the concepts of language processing, contextual analysis, distributed deep learning, big data, anomaly detection of flow analysis. We propose a model that describes the network abstract normal behavior from a sequence of millions of packets within their context and analyzes them in near real-time to detect point, collective and contextual anomalies. Experiments are done on MAWI dataset, and it shows better detection rate not only than signature IDS, but also better than traditional anomaly IDS. The experiment shows lower false positive, higher detection rate and better point anomalies detection. As for prove of contextual and collective anomalies detection, we discuss our claim and the reason behind our hypothesis. But the experiment is done on random small subsets of the dataset because of hardware limitations, so we share experiment and our future vision thoughts as we wish that full prove will be done in future by other interested researchers who have better hardware infrastructure than ours.
The Efficacy of Mitotane in Human Primary Adrenocortical Carcinoma Cultures
Authors: van Koetsveld Peter M , Creemers Sara G , Dogan Fadime , Franssen Gaston J H , de Herder Wouter W , Feelders Richard A , Hofland Leo J 
Published: October 2019

Abstract

Context
Patients with adrenocortical carcinoma (ACC) often fail mitotane treatment and deal with severe toxicity, marking the relevance of predictive parameters for treatment outcome.

Objective
Determine the effects of mitotane in primary ACC cultures, and correlate sensitivity with patient and tumor characteristics.

Methods
In 32 primary ACC cultures, the effects of mitotane on cell growth and cortisol production were determined. RRM1, SOAT1, and CYP2W1 expression were assessed using reverse transcription-polymerase chain reaction and immunohistochemistry.

Results
The median percentage cell amount inhibition in primary ACC cultures at 50 µM mitotane was 57%. Seven patients were classified as nonresponders, 14 as partial responders, and 11 as responders. The mean median effective concentration (EC50) value of mitotane for inhibition of cell amount in responders was 14.2 µM (95% CI, 11.3–17.9), in partial responders 41.6 µM (95% CI, 33.5–51.8), and could not be calculated in nonresponders. The percentage cortisol-producing ACC was 14%, 43%, and 73% for nonresponders, partial responders, and responders (P = 0.068). Mitotane inhibited cortisol production with a mean EC50 of 1.4 µM (95% CI, 0.9–2.1), which was considerably lower than the EC50 on cell growth. RRM1, SOAT1, and CYP2W1 expression levels were not predictive for mitotane sensitivity in vitro.

Conclusion
Direct antitumor effects of mitotane on human primary ACC cultures are highly variable between patients, reflecting heterogeneous responses in patients. Cortisol was inhibited at lower concentrations, compared with its effect on cell amount. Cortisol secretion by ACC might be associated with enhanced mitotane sensitivity due to increased direct antitumor effects of mitotane.