bluuebunny/crossref_metadata_2025_split huggingface dataset:
ARRANJOS DE GOVERNANÇA PARA PESSOAS IDOSAS: um breve panorama dos conselhos federativos no Brasil
Authors: Mourad Leonice Aparecida de Fatima Alves Pereira , Bernartt Maria de Lourdes 
Published: December 2024

O artigo resulta de investigação bibliográfica e exploratória sobre a governança de políticas públicas para a pessoa idosa, no contexto brasileiro, a partir da capilaridade e das atribuições dos Conselhos Municipais da Pessoa Idosa. Objetivou-se compreender as modificações normativas destinadas a esse público, nacional e internacionalmente, e sua relação com a crescente percepção sobre a vulnerabilidade que incide sobre esse grupo. A pesquisa pautou-se na legislação nacional e internacional, e na base de dados disponibilizada pelo governo federal sobre a configuração destes Conselhos. Evidenciou-se a preocupação com o envelhecimento, em escala mundial, demandando uma série de normativas, as quais têm norteado ações governamentais e civis protegendo os direitos de pessoas idosas. Arranjos de governança, como os conselhos federativos, especialmente os municipais, têm exercido função importante no fomento de estratégias de controle da execução das políticas públicas para pessoas idosas.
Chamanismo y evangelismo entre los shipibo-konibo de San Francisco
Authors: Slaghenauffi Doriane Sabine 
Published: December 2024

En contacto regular con la civilización urbana y la economía de mercado, la sociedad shipibo-konibo conoce hoy un fenómeno de pluralización religiosa entre, por un lado, una comercialización, en algunos pueblos, del chamanismo vernáculo destinada a un público de turistas occidentales en busca de experiencias místicas y alucinógenas y, por otro, una implantación creciente de iglesias protestantes de diferentes denominaciones. Si, a primera vista, esta evolución puede analizarse como una forma de aculturación, a la luz de la etnografía, por el contrario, la cohabitación religiosa resultante reactiva un cierto complejo de predación propio del pasado, a través de rivalidades a la vez ontológicas y estatutarias que estarían vinculadas a una proximidad demasiado grande de los enfoques de las dos instituciones.
Decadal architecture and morphodynamics of modern, river-fed turbidite systems: Bute Inlet and Congo Fan
Authors: Lobato Gustavo , Postma George , Lintern D. Gwyn , Jacinto Ricardo S. , Cartigny Matthieu J.B. 
Published: December 2024

ABSTRACT
Modern active turbidite systems transport and store more sediments than any other sedimentary system. However, the depositional architecture which links these stored sediments to this short-term morphodynamics is not well understood due to the limited available monitoring data. Time-lapse bathymetric surveys were analyzed over a period of 20 years for two river-fed turbidite systems: eleven surveys for Bute Inlet (West Canada) and five for the Congo Fan (West Africa). Time-lapse maps show the evolution of erosion and deposition zones, which are related to the upslope migration of erosional and depositional features including knickpoints. Erosion–deposition zones (EDZs) occur as large, several-km-size steps with increasing length towards the lower channel. These intra-system deposition zones form large turbidite bodies described as macroforms, which onlap the adjacent, upslope erosion zone. The erosion and deposition zones are covered with mesoscale (meters scale high and tens to hundreds of meters long), crescentic and wavy bedforms extending down to the lobe. From the time-lapse maps, it is inferred that both macroscale and mesoscale bedforms are formed synchronously by ordinary seasonal events occurring once or a few times a year. Extreme seasonal events, occurring once in a decade, produce longer-wavelength EDZs. Four different, decadal architectural styles of turbidite macroforms are described from map views and cross sections. These reflect a continuum from confined-flow to unconfined-flow-related deposition. Calculated internal sediment budgets over EDZs indicate that about 50% of the sediment is stored in the transfer-zone macroforms, while only the remaining 50% reaches the terminal deposition zone over the two-decade monitoring period. About 40% of the total sediment erosion occurs distally in the lower channel and plays an important role in delivering sediments which build the terminal turbidite deposition zone. The short-term morphodynamics of EDZs represent an autogenic sand detachment mechanism in both the transfer zone and terminal deposition zone, which potentially create isolated depositional units meters to tens of meters thick and some kilometers in length in ancient turbidite systems.
Age-related Differences in Bimanual Isometric Force Tracking
Authors: Galofaro Elisa , Valè Nicola , Ballardini Giulia , Smania Nicola , Casadio Maura 
Published: December 2024

Abstract

Bimanual force coordination is essential for various daily interactions with objects. Although the age- related decline in sensory perception and motor function has been extensively studied, the effects of aging on the bilateral control of isometric forces remain less explored. This study aims to comprehensively describe the bimanual force control strategies employed by unimpaired young and older adults during an isometric force tracking task. Partic- ipants were instructed to apply equal isometric force with both hands simultaneously by pushing against two decou- pled plates, simulating the lateral faces of a box on a table. The total force had to match a profile that included both time-varying and constant phases, targeting three distinct force levels. Visual feedback of the total force was provided throughout the task. Thirty-one volunteers participated in the study: 15 younger adults of age 25±1 (mean±std) years and 16 older participants of age 77±7 (mean±std) years. Differences between the two age groups were analyzed using repeated measures ANOVA, with group as a between- subjects factor. Results indicated that older adults exhib- ited lower accuracy and greater variability in force exertion compared to the younger participants, with these differ- ences being more pronounced for the time-varying force profile. Additionally, the older group demonstrated reduced between-hands force correlations and reduced bilateral symmetry. Notably, the percentage of total force exerted by the left hand was negatively correlated with the disparity between the left and right coefficients of variation. This study enhances our understanding of the impact of aging on sensorimotor control in bimanual isometric force tasks, utilizing a cost-effective sensorized device.
WITHDRAWN: Near-full-length genomic sequences of two novel HIV-1 recombinant forms identified in Hebei Province, China
Authors: Zhang Zhen , Zhao Feng , Chen Sisi , Shi Haoxi , Shi Penghui , Fan Weiguang 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Reconciling tracked atmospheric water flows to close the global freshwater cycle
Authors: De Petrillo Elena , Fahrländer Simon , Tuninetti Marta , Andersen Lauren , Monaco Luca , Ridolfi Luca , Laio Francesco 
Published: December 2024

Abstract

Atmospheric moisture plays a vital role in the hydrological cycle, connecting evaporation sources to precipitationsinks. While high-resolution moisture-tracking models offer valuable insight, discrepancies to atmospheric re-analysis dataemerge. In this study, we reconcile tracked atmospheric water flows with reanalysis data, using the Iterative ProportionalFitting procedure (IPF). We apply IPF to the atmospheric moisture flows from the UTrack dataset (averaged over 2008-2017),aggregated within countries and ocean boundaries. This reconciled dataset ensures that the total tracked atmospheric moisture5equals the total precipitation at the sink and evaporation at the source on an annual basis. Country-scale discrepancies of upto 275% in precipitation and 225% in evaporation are amended, correcting fluxes by∼0.07%, on average. We find 45% ofthe total terrestrial precipitation (∼1.5·105km3yr−1) originates from land evaporation (9.8·104km3yr−1). Our reconciledcountry-scale dataset offers new ground to investigate transboundary atmospheric water flows which connect us globally.
Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons
Authors: Schmidt Malin , Hoffrichter Anne , Davoudi Mahnaz , Horschitz Sandra , Lau Thorsten , Meinhardt Marcus , Spanagel Rainer , Ladewig Julia , Köhr Georg , Koch Philipp 
Published: December 2024

Abstract

Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons derived from induced pluripotent stem cells with the 5-HT2A receptor agonist psilocin - the psychoactive metabolite of psilocybin. We analyzed how exposure to psilocin affects 5-HT2A receptor localization, gene expression, neuronal morphology, synaptic markers and neuronal function. Upon exposure of human neurons to psilocin, we observed a decrease of cell surface-located 5-HT2A receptors first in the axonal- followed by the somatodendritic-compartment. Psilocin further provoked a 5-HT2A-R-mediated augmentation of BDNF abundance. Transcriptomic profiling identified gene expression signatures priming neurons to neuroplasticity. On a morphological level, psilocin induced enhanced neuronal complexity and increased expression of synaptic proteins, in particular in the postsynaptic-compartment. Consistently, we observed an increased excitability and enhanced synaptic network activity in neurons treated with psilocin. In conclusion, exposure of human neurons to psilocin might induces a state of enhanced neuronal plasticity which could explain why psilocin is beneficial in the treatment of neuropsychiatric disorders where synaptic dysfunctions are discussed.
Genome-wide analysis of DnaJA proteins in Nicotiana tabacum reveals that NtDnaJA3 responses to drought stress
Authors: Wang Qiao , Meng Lijun , Qu Zechao , Su Huan , Tao Jiemeng , Lu Peng , Zhang Jianfeng , Cao Peijian , Jin Jingjing 
Published: December 2024

Abstract

Background
DnaJA proteins, a prominent subfamily of the DnaJ family, function as molecular chaperones that respond to various external stresses. Extensive studies on the DnaJ family have been conducted in plants. However, research on this subfamily in tobacco remains relatively scarce.
Results
In this study, we identified 24 DnaJA genes in tobacco, and classified them into three individual groups. A comprehensive analysis based on gene structure, motif composition, and evolutionary pattern revealed the divergence of tobacco DnaJA genes. For the evolution of the NtDnaJA genes, purification selection was the major factor. In addition, the potential regulatory network unveiled that NtDnaJAs could be regulated by miRNAs and various transcription factors associated with diverse stress responses. Through expression pattern analysis and qRT-PCR experiments, it was observed that many NtDnaJAs displayed tissue-specific expression and might play significant roles in different biotic and abiotic stresses. Additionally, the pivotal role of NtDnaJA3 in boosting plant drought resistance was confirmed.
Conclusions
This study provides important perspectives on the evolution of NtDnaJA genes and their involvement in stress responses, laying the groundwork for future research into the roles of DnaJA regulatory genes in tobacco.
Graphical Abstract
Influence of AI Behavior on Human Moral decisions, Agency, and Responsibility
Authors: SALATINO Adriana , Prével Arthur , Caspar Emilie , Bue Salvatore Lo 
Published: December 2024

Abstract

There is a growing interest in understanding the effects of human-machine interaction on moral decision-making (Moral-DM) and sense of agency (SoA). Here, we investigated whether the “moral behavior” of an AI may affect both moral-DM and SoA in a military population, by using a task in which cadets played the role of drone operators on a battlefield. Participants had to decide whether or not to initiate an attack based on the presence of enemies and the risk of collateral damage. By combining three different types of trials (Moral vs. two No-Morals) in three blocks with three type of intelligent system support (No-AI support vs. Aggressive-AI vs. Conservative-AI), we showed that participants' decisions in the morally challenging situations were influenced by the inputs provided by the autonomous system. Furthermore, by measuring implicit and explicit agency, we found a significant increase in the SoA at the implicit level in the morally challenging situations, and a decrease in the explicit responsibility during the interaction with both AIs. These results suggest that the AI behavior influences human moral decision-making and alters the sense of agency and responsibility in ethical scenarios. These findings have implications for the design of AI-assisted decision-making processes in moral contexts.
Proactive Fault-Recovery on Distributed Software-Defined Network Controllers
Authors: Delfino Wilker O. , Quincozes Silvio E. , Vieira Juan L. , Passos Diego , Muchaluat-Saade Débora , Albuquerque Célio , Mossé Daniel 
Published: December 2024

Abstract

Distributing the control plane on Software-Defined Networks (SDN) is a promising approach for improving network robustness. Using this approach, the control plane becomes physically distributed but logically centralized. This distributed SDN controller architecture reduces the controller's overload and enables a quick response time between controllers and switches. Besides, in case of network or controller failure, it decreases the time needed for fault recovery. In this work, we propose an approach to reduce the average recovery time on faulty scenarios based on the proactive processing and response of SDN switch requests by multiple controllers, relying on OpenFlow's Equal role. We also develop a proof-of-concept implementation in real and emulated switches to show the analysis of the recovery time from failures. Our results reveal that the proactive approach can reduce the average recovery time for controller failures by three orders of magnitude --- down to 10 milliseconds in the evaluated scenarios.
Hyperbolic Graph Convolutional NetworkRelation Extraction Model CombiningDependency Syntax and Contrastive Learning
Authors: Li Jinzhe 
Published: December 2024

Abstract

In current relation extraction tasks, when the input sentence structure is complex,the performance of in-context learning methods based on large language modelis still lower than that of traditional pre-train fine-tune models. For complex sen-tence structures, dependency syntax information can provide effective prior textstructure information for relation extraction. However, most studies are affectedby the noise in the syntactic information automatically extracted by natural lan-guage processing toolkits. Additionally, traditional pre-training encoders haveissues such as an overly centralized representation of word embedding for high-frequency words, which adversely affects the model to learn contextual semanticinformation. To address proposed problem, the paper proposes a HyperbolicGraph Convolutional Network Relation Extraction Model Combine DependencySyntax and Contrastive Learning. Based on the hyperbolic graph neural net-work, dependent syntactic information and information optimization strategiesare introduced to solve the problem of word embedding concentration. Simulta-neously, to mitigate the impact of noise in dependency syntax information onthe relation extraction task, a contrastive learning approach is employed. Afterthe model learns context semantics separately in the original dependency syn-tax information and dependency syntax information with added random noise,it maximizes the mutual information between entity words to assist the modelin distinguishing noise in dependency syntax. The experiments indicate that theproposed model in this paper can effectively enhance the performance of relationextraction on public datasets, especially achieving significantly higher precisionon datasets with complex sentence structures compared to in-context learning.
Nesfatin-1 Exerts a Neuroprotective Effect in Thioacetamide-Induced Acute Hepatic Encephalopathy by Activating the PI3K/Akt/Nrf2 Pathway
Authors: Faheem Heba , Alawadhi Rana , Khattab Haidy , Ellatif Rasha A. Abd , Abdel-Kareem Mona A. , El-Azeem Alaa H. Abd , Elkordy Alaa , Nasef Nahla Anas , Dawood Lamees Mohamed , Tabaa Maram Mohammed El , Tabaa Manar Mohammed El , Rizk Fatma H. 
Published: December 2024

Abstract

Nesfatin-1 possesses antioxidative and antiapoptotic properties. It can protect against subarachnoid hemorrhage and brain-induced injury by reducing the activation of the pro-apoptotic protein caspase-3 and the levels of oxidative brain injury indicators. We aimed to investigate the protective effect of nesfatin-1 on the acute hepatic encephalopathy (HE) model in rats. The rats were assigned to five groups in the following manner: The Control Group received only saline. The Nesfatin-1 Control Group received both nesfatin-1 and saline. The HE Group received the vehicle and thioacetamide to induce HE. The HE + Nesfatin-1 Group received both nesfatin-1 and thioacetamide. The HE + Nesfatin-1 + heme oxygenase-1 (HO-1) Inhibitor Group received nesfatin-1, thioacetamide, and the HO-1 inhibitor ZnppIX. Psychomotor activity in rats was assessed. The levels of HO-1 and fibrillary acidic protein (GFAP) were quantitatively measured. In addition, histological examinations were conducted. Nesfatin-1 resulted in a significant improvement in psychomotor activity, a decline in brain edema, and a decrease in inflammatory and oxidative stress markers. Furthermore, it led to the activation of phosphatidylinositol 3 kinase/ protein kinase B/nuclear factor erythroid 2–related factor 2 pathways, upregulated HO-1 and GFAP expressions, and improved HE-induced structural damage in the liver and brain. Furthermore, there was a decrease in caspase-3 expression in the liver and brain, as well as a decline in nuclear factor-κB/p65 expression in brain tissue. In summary, nesfatin-1 is considered a promising drug that can be used as a neuroprotective in HE due to its anti-inflammatory, antioxidative, and antiapoptotic effects.
SigmaR1 is a lipid-binding component of the translocon complex that regulates lipid droplet homeostasis
Authors: Ji Weike , hu xuewen , zhou Tiantian , Xiong Juan 
Published: December 2024

Abstract

Sigma Non-Opioid Intracellular Receptor 1 (SigmaR1) is a member of the sigma family of receptors that interacts with a variety of psychotomimetic drugs and has been involved in a wide range of cellular and physiological functions. Despite its increasing importance in human physiology and disease, the subcellular localization of SigmaR1 and its molecular function remain poorly defined. Using endogenous tagging and cell fractionation, we show that SigmaR1 is a type II integral ER membrane protein that is specifically enriched at ER sheet. A short region at the N-terminus of SigmaR1 is sufficient and required for its ER-sheet localization. Importantly, our biochemical studies demonstrate that SigmaR1 directly interacts with several key components of the transposon complex including TRAPα and Nicalin via the N-terminal region. Interestingly, we found that the β-barrel structure at the C-terminal of SigmaR1 binds to phosphatidylcholine. SigmaR1 knockout systematically impaired cellular protein and lipid homeostasis, resulting in an accumulation of lipid droplets in hepatocytes. Collectively, we propose that SigmaR1 is a lipid-binding component of the translocon complex, which may contribute to the broad and vital roles of SigmaR1 in physiology and disease.
Synchronous Unilateral Breast Cancer with HER2-Positive and TNBC Subtypes: Diagnostic and Therapeutic Challenges. A Case Report and Literature Review
Authors: Mokhtar Jonathan , Almarzooqi Shaikha , Alhammadi Fatima , Akashi Marwa , Grassi Veronica , Rafii Saeed 
Published: December 2024

Abstract

Synchronous unilateral breast cancer presenting with different receptor subtypes are rare occurrences, with limited reports in the medical literature. Such cases pose unique diagnostic and therapeutic challenges. We present a case of a young patient initially diagnosed with a biopsy proven HER2-positive invasive ductal carcinoma, who was subsequently, upon further imaging, diagnosed with a second invasive ductal carcinoma with triple negative breast cancer in the same breast. This case underscores the significance of meticulous evaluation of the whole breast in the context of an existing carcinoma. Additionally, we emphasize the pivotal role of multidisciplinary teams, and review the current literature related to biology and treatment of such patients.
Economic and environmental impacts of Telemedicine: insights from a Brazilian orthopedic referral center
Authors: Yamaguchi Fabio Seiji Mazzi , Kroes Hector Fugihara , Martins Gabriel Benevides Valiate , Lage Gustavo Estefan , Silva Vitor Matheus , Rudelli Bruno Alves , Marcon Raphael Martus , Gurgel Henrique Melo de Campos 
Published: December 2024

Abstract

Introduction: Telemedicine has emerged as a key tool to overcome socioeconomic disparities, expand healthcare access, and reduce environmental impacts. Its adoption surged during the COVID-19 pandemic, minimizing travel-related barriers and ensuring continuity of care. In Brazil, where regional inequities in healthcare access and pollution heavily affect public health, telemedicine holds significant promise. However, further research is needed to quantify its economic and environmental benefits. Moreover, examining how socioeconomic factors influence patients' preferences for telemedicine is essential. These correlations help identify patterns that may influence telemedicine adoption and provide deeper insights into how socioeconomic factors can affect access to and benefits from remote healthcare services.
Objective: To evaluate the economic and environmental impacts of telemedicine use and the correlation of socioeconomic variables with telemedicine preference in patients with hip pathologies at a tertiary referral center in São Paulo, Brazil.
Methods: A cross-sectional study (January-June 2024) analyzed telemedicine patients, collecting data on preferences, demographics, travel, and costs (transport and food). Avoided distance, time, and pollutant emissions were calculated using Google Maps and emission factors. Correlations were conducted between patients' preference for telemedicine and their socioeconomic data. Statistical analyses used Wilcoxon, chi-square, and logistic regression tests.
Results: 148 patients participated, with 77.7% preferring telemedicine. The mean avoided travel distance was 168.84 km, with a mean time saving of 223.97 minutes. Patients using public transport and private cars saved, respectively, USD 12.62 and USD 28.95. Telemedicine also reduced pollutant emissions, avoiding approximately 7 tons of carbon dioxide. Telemedicine preference was positively associated with higher income (p = 0.0283). Other variables showed no statistically significant associations.
Conclusion: Telemedicine led to significant time and cost savings, as well as a reduction in pollutant emissions. These findings demonstrate telemedicine’s potential to improve access and reduce environmental impacts. Preference for telemedicine was positively associated with higher income, highlighting potential barriers for lower-income populations. Further research is needed to address the lower adherence to virtual consultations among socioeconomically disadvantaged groups.