bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bolus Airway Invasion Observed During Videofluoroscopy in Healthy, Non-dysphagic Community-Dwelling Adults
Authors: Garand Kendrea L. (Focht) , Hill Elizabeth G. , Amella Elaine , Armeson Kent , Brown Alonna , Martin-Harris Bonnie 
Published: January 2019

Objectives: Typical aging may result in subclinical swallowing alterations (presbyphagia), which can place an individual at risk for dysphagia-related conditions, such as aspiration pneumonia, secondary to loss of functional reserve and rising incidence of age-related diseases associated with dysphagia. The purpose of this study was to investigate occurrence of airway invasion among healthy, nondysphagic community-dwelling adults. Further, we tested for differences of airway invasion across age categories and between sexes. Methods: Each eligible participant underwent a videofluoroscopic swallow study using a standardized approach of various volumes and viscosities. Ten swallows observed in the lateral viewing plane was assessed for observation of bolus airway invasion using the Penetration-Aspiration Scale (PAS) scoring system. Eligible participants (N = 195) were categorized according to 1 of 3 age categories (21-39 years, 40-59 years, 60 years and older) and sex (male, female) for analyses. Results: Out of 1936 swallows analyzed, we observed penetration in 113 swallows (5.8%) and aspiration in 6 swallows (0.3%). Majority (98%) of bolus airway invasion events occurred during the swallow. Mean or worst PAS scores did not significantly differ across age categories or between sexes. The odds ratios of PAS impairment between age categories did not reveal any significant differences. Males were more likely to have impaired PAS scores relative to females (odds ratio [OR] = 3.5; P = .01). Conclusions: Entrance of ingested material into the airway observed during videofluoroscopy is uncommon in healthy adults, which helps support the notion that aging may not directly correlate with increased risk of aspiration. Rather, the increased risk of aspiration observed in the aging population may result from the increased incidence of neurological and other diseases with dysphagia as common sequelae with advancing age. Future investigations should compare age-matched healthy controls with a diseased population (eg, cerebral vascular accident) to further explore the relationship between aspiration risk as a function of age compared to consequence of disease/injury.
A new model for accurate estimation of gas content and pressure based on Langmuir adsorption equation in Guizhou, China
Authors: Li Qingsong , Wang Enyuan , Duan Zhengpeng , Zhu Junkui , Wu Jiahao 
Published: January 2019

In order to obtain the functional relationship of gas content and gas pressure, and to accurately calculate the two values which fitting the characteristics of coal seam, the destruction coefficient (X) and the index (ΔP) of the initial velocity of gas emission are introduced to establish the new model with higher precision based on Langmuir equation and destruction type of coal. The applicability of classic model (W-P model) and new optimization model in Guizhou mining areas are studied through the statistics of basic parameter data from 107 groups of coal-seam gas in eight mining areas. The results show that the gas content calculated by the classical model is lower than the measured value, while the gas pressure value is larger than that. The average relative error of gas content and pressure data reach 23.98% and 97.86%, respectively. The gas content and pressure data calculated by the optimization model are well fitted with the measured value. The fitting degree gradually rises with the increase of the sample size, and the average relative errors are 6.44% and 14.27%, respectively. Compared with the classical model, the average relative errors of gas content and pressure calculated by the optimization model reduce by 17.54% and 83.59%, respectively. The optimization model controls the tendency of calculated value error which significantly rises as the ΔP increases. For the coals with different destruction types, the average relative error of calculated gas content in optimization model ranges from 4.40% to 11.99%. And the average relative error of calculated pressure value ranges from 9.84% to 25.80%, both of them are far superior to that of classical model. The optimization model is more accurate for calculating the gas content and pressure in Guizhou.
Chronic stress: a crucial promoter of cell apoptosis in atherosclerosis
Authors: Meng Ling-bing , Shan Meng-jie , Yu Ze-mou , Lv Jian , Qi Ruo-mei , Guo Peng , Zhang Yuan-meng , Gong Tao 
Published: January 2019

Objective Chronic stress may lead to augmented incidence rates of coronary and cerebrovascular diseases associated with atherosclerosis. However, few studies have focused on the effect of chronic stress on atherosclerosis plaque formation. Therefore, this study was designed to directly evaluate how chronic stress affects atherosclerosis. Methods Thirty rabbits were divided into three groups: the control group, balloon-injury operation + high-fat diet model group, and chronic stress + balloon-injury operation + high-fat diet model group. Physical and social stress were induced, and proteomic methods were applied to identify specific markers. Results After protein determination, the chronic stress + balloon-injury operation + high-fat diet model group exhibited significant upregulation of the following apoptosis-related proteins: UBE2K, caspase 3, caspase 9, BAX, P53, and FAS. In particular, real-time polymerase chain reaction showed that the protein expression of caspase 9 was significantly downregulated in the stress group compared with the non-stress groups. However, the other proteins showed significantly increased expression in the stress group. Conclusion Chronic stress may promote cell apoptosis in the physiopathologic process of atherosclerosis.
Propofol-based balanced anesthesia is safer in pediatric radiotherapy
Authors: Yıldırım İlknur , İ Çelik Ayça , B Bay Sema , Pasin Özge , Tütüncü Ayşe Ç 
Published: January 2019

Backround and purpose To investigate the incidence of complications related to propofol-based anesthesia and the factors associated with complications in children with radiotherapy. Materials and methods Patients who underwent anesthesia for external beam radiotherapy between May 2013 and November 2017 were included in the study. We assessed the age/weight, sex, oncologic diagnosis, type of radiotherapy procedure, duration of anesthesia, applied agents, and complications related to anesthesia. Complications were evaluated between group I (only propofol group) and group II (propofol plus adjuvant drugs) as respiratory and cardiac. Results In 130 patients, sedation was given for 1376 radiotherapy procedures. Of these, 1274 (1140 radiation treatment sessions and 134 computed tomography simulations) in 126 patients were propofol-based and were included in the analysis. Although respiratory complications are the most common in both groups, there were no episodes of laryngospasm, broncospasm, and no use of advanced airway intervention. The rate of complication was significantly higher in only propofol anesthesia group than in patients treated with propofol plus adjuvant drugs. In the multivariate analysis, we found three factors that were significantly associated with the risk of complications: total dose of propofol (mg/kg) (p < 0.001), anesthesia with propofol alone (as compared to propofol plus adjunct agents) (p = 0.001), and diagnosis of neuroblastoma (as compared to other diagnosis) (p = 0.043). Conclusion Propofol-based anesthesia is preferred in order to minimize the rate of complications in radiotherapy anesthesia applications. The use of non-opioid adjuvants in combination with propofol to achieve a balanced anesthesia will also reduce the complications that may be encountered.
A Pilot Study Using a Multistaged Integrated Analysis of Gene Expression and Methylation to Evaluate Mechanisms for Evening Fatigue in Women Who Received Chemotherapy for Breast Cancer
Authors: Flowers Elena , Flentje Annesa , Levine Jon , Olshen Adam , Hammer Marilyn , Paul Steven , Conley Yvette , Miaskowski Christine , Kober Kord M. 
Published: January 2019

Context: Fatigue is the most common symptom associated with cancer and its treatment. Investigation of molecular mechanisms associated with fatigue may identify new therapeutic targets. Objective: The objective of this pilot study was to evaluate the relationships between gene expression and methylation status and evening fatigue severity in women with breast cancer who received chemotherapy. Methods: Latent class analysis (LCA) was used to identify evening fatigue phenotypes. In this analysis, the lowest (i.e., moderate, n = 7) and highest (i.e., very high, n = 29) fatigue-severity classes identified using LCA were analyzed via two stages. First, a total of 32,609 transcripts from whole blood were evaluated for differences in expression levels between the classes. Next, 637 methylation sites located within the putative transcription factor binding sites for those genes demonstrating differential expression were evaluated for differential methylation state between the classes. Results: A total of 89 transcripts in 75 unique genes were differentially expressed between the moderate (the lowest fatigue-severity class identified) and very high evening fatigue classes. In addition, 23 differentially methylated probes and three differentially methylated regions were found between the moderate and very high evening fatigue classes. Conclusions: Using a multistaged integrated analysis of gene expression and methylation, differential methylation was identified in the regulatory regions of genes associated with previously hypothesized mechanisms for fatigue, including inflammation, immune function, neurotransmission, circadian rhythm, skeletal muscle energy, carbohydrate metabolism, and renal function as well as core biological processes including gene transcription and the cell-cycle regulation.
Genetic Variants and the Cortisol Response in Children: An Exploratory Study
Authors: Ersig Anne L. , Schutte Debra L. , Standley Jennifer , Leslie Elizabeth J. , Zimmerman Bridget , Hanrahan Kirsten , Murray Jeffrey C. , McCarthy Ann Marie 
Published: January 2019

Objective: We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure. Design: Children 4–10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distress: two on the day of the procedure and two at home on a nonstressful day for comparison values. Children and biological parents also provided samples for genotyping of variants with known or suspected association with the cortisol stress response. Analysis included child-only association and family-based transmission disequilibrium tests (TDTs). Results: Genotype and phenotype data on the cortisol stress response were available from 326 children for child-only association analyses and 376 complete family trios for TDTs. Children were 50% female, an average of 7.5 years old, and mostly (83%) White/non-Hispanic. We identified four single-nucleotide polymorphisms (SNPs) potentially associated with the cortisol stress response: rs1176744 ( HTR3B), rs10062367 ( CRHBP), rs634479 ( OPRM1), and rs8030107 ( NTRK3). Family-based analysis identified a two-SNP haplotype in HTR1B suggestive for association with the cortisol response (rs6296, rs11568817). Allelic TDTs identified rs7897947 ( NFKB2) as potentially related to cortisol response. Conclusions: Findings provide preliminary evidence for genes potentially important in cortisol response to an acute stressor in children in the serotonin, dopamine, and brain-derived neurotrophic factor pathways, the hypothalamic–pituitary–adrenal axis, and the inflammatory response. Combined with analyses of related phenotypes and clinical data, these results could help identify patients at increased risk of adverse responses to painful medical procedures who might benefit from tailored interventions.
The Fraction Exhaled Nitric Oxide as a Biomarker of Asthma Control
Authors: de Abreu Fernanda Cruvinel , da Silva Júnior Jose Laerte Rodrigues , Rabahi Marcelo Fouad 
Published: January 2019

Introduction and Objective: The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is a biomarker of T-helper cell type 2 (Th2) inflammation of the airways. Our objective was to determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled, and uncontrolled asthma. Materials and Methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross-sectional study through data collected from asthmatic patients who were assessed by clinical history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was determined by the criteria of the Global Initiative for Asthma and classified as controlled asthma, partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low (<25 ppb) or intermediate/high (⩾25 ppb) based on the American Thoracic Society recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled (34 [42%] patients), partially controlled (27 [33.3%] patients), and uncontrolled (20 [24.7%] patients). The FeNO level discriminated between the uncontrolled and controlled groups ( P = .01) and between the uncontrolled and partially controlled groups ( P = .01), but not between the controlled and partially controlled groups ( P = .98). An FeNO level >30 ppb was associated with uncontrolled asthma ( P = .0001) with an area under the receiver operating characteristic curve of 0.78 (95% confidence interval = 0.65-0.89). Conclusions: FeNO level could be helpful in determining asthma control as >30 ppb was associated with uncontrolled asthma.
Use of paraffin instead of lukewarm water prior to hand exercises had no additional effect on hand mobility in patients with systemic sclerosis: A randomized clinical trial
Authors: Kristensen Lola Q , Oestergaard Lisa G , Bovbjerg Karina , Rolving Nanna , Søndergaard Klaus 
Published: January 2019

Introduction Systemic sclerosis is a connective tissue disease associated with significantly impaired hand mobility, which may hamper activities of daily living. The aim of the present study was to investigate the effect on hand mobility and health status of patients with systemic sclerosis of warming up hands with paraffin compared with warming up hands in lukewarm water prior to hand exercises. Methods Patients were allocated to receive either warm-up treatment with water or paraffin prior to hand exercises for a period of six months. Primary outcome was Hand Mobility in Scleroderma (HAMIS), while secondary outcomes included SF-36 and measurements of fingertips to proximal and distal palmar crease. Follow-up assessments were conducted 3, 6 and 12 months post baseline. Results Ninety patients were enrolled in the study and 56 patients completed. No statistically significant differences were observed between groups regarding hand mobility post intervention. Within both groups, hand mobility improved on the HAMIS six months post baseline with −2.6 points (95% CI: −4.4; −0.8) in the paraffin group and −3.3 points (95% CI: −5.2; −1.5) in the water group. Improvements were maintained at 12-month follow-up. Conclusions Our findings suggested that warm-up with paraffin compared to lukewarm water prior to hand exercises in patients with systemic sclerosis had no additional effect on hand mobility. Results may have been affected by the high dropout rate and statistical errors underestimating a possible effect.
Nasal Glucagon Versus Injectable Glucagon for Severe Hypoglycemia: A Cost-Offset and Budget Impact Analysis
Authors: Pöhlmann Johannes , Mitchell Beth D. , Bajpai Sanjay , Osumili Beatrice , Valentine William J. 
Published: January 2019

Background: Severe hypoglycemic events (SHEs) in patients with diabetes are associated with substantial health care costs in the United States (US). Injectable glucagon (IG) is currently available for treatment of severe hypoglycemia but is associated with frequent handling errors. Nasal glucagon (NG) is a novel, easier-to-use treatment that is more often administered successfully. The economic impact of this usability advantage was explored in cost-offset and budget impact analyses for the US setting. Methods: A health economic model was developed to estimate mean costs per SHE for which treatment was attempted using NG or IG, which differed only in the probability of treatment success, based on a published usability study. The budget impact of NG was projected over 2 years for patients with type 1 diabetes (T1D) and type 2 diabetes treated with basal-bolus insulin (T2D-BB). Epidemiologic and cost data were sourced from the literature and/or fee schedules. Results: Mean costs were $992 lower if NG was used compared with IG per SHE for which a user attempted treatment. NG was estimated to reduce SHE-related spending by $1.1 million and $230 000 over 2 years in 10 000 patients each with T1D and T2D-BB, respectively. Reduced spending resulted from reduced professional emergency services utilization as successful treatment was more likely with NG. Conclusions: The usability advantage of NG over IG was projected to reduce SHE-related treatment costs in the US setting. NG has the potential to improve hypoglycemia emergency care and reduce SHE-related treatment costs.
Chemoselective Hydrogenation of 4-Nitrostyrene to 4-Aminostyrene by Highly Efficient TiO2 Supported Ni3Sn2 Alloy Catalyst
Authors: Yamanaka Nobutaka , Hara Takayoshi , Ichikuni Nobuyuki , Shimazu Shogo 
Published: January 2019

Abstract
Ni3Sn2 alloy catalysts supported on various metal oxides (TiO2, Al2O3, ZrO2, SnO2, and CeO2) were successfully prepared by simple hydrothermal method and then applied to the hydrogenation of 4-nitrostyrene under H2 3.0 MPa at 423 K. All the supported catalysts hydrogenated the nitro group more preferentially than the olefin group from the initial reaction stages, showing 100% chemoselectivities towards the desired 4-aminostyrene. This may be attributed to σ-interaction between the oxygen lone pairs in the nitro group and Sn atoms in Ni3Sn2 alloy. By prolonging the reaction times, the 4-aminostyrene yields increased and finally reached the maximum yields. Among the catalysts, Ni3Sn2/TiO2 alloy catalyst showed the highest catalytic activity with remarkably high chemoselectivity towards 4-aminostyrene. The conversion and chemoselectivity were 100% and 79%, respectively, at a reaction time of only 2.5 h. From the physical and chemical characterization of the supported catalysts, it was clear that the catalytic activity was correlated with H2 uptake. The application of the best catalyst for the hydrogenation of a wide variety of substituted nitroarenes resulted in the chemoselective formation of the corresponding aminoarenes.
The diagnosis of tuberculous meningitis in adults and adolescents: protocol for a systematic review and individual patient data meta-analysis to inform a multivariable prediction model
Authors: Boyles Tom , Stadelman Anna , Ellis Jayne P. , Cresswell Fiona V. , Lutje Vittoria , Wasserman Sean , Tiffin Nicki , Wilkinson Robert 
Published: January 2019

Background: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis. Delayed diagnosis and treatment, which is a risk factor for poor outcome, is caused in part by lack of availability of diagnostic tests that are both rapid and accurate. Several attempts have been made to develop clinical scoring systems to fill this gap, but none have performed sufficiently well to be broadly implemented. We aim to identify and validate a set of clinical predictors that accurately classify TBM using individual patient data (IPD) from published studies. Methods: We will perform a systematic review and obtain IPD from studies published from the year 1990 which undertook diagnostic testing for TBM in adolescents or adults using at least one of, microscopy for acid-fast bacilli, commercial nucleic acid amplification test for Mycobacterium tuberculosis or mycobacterial culture of cerebrospinal fluid. Clinical data that have previously been shown to be associated with TBM, and can inform the final diagnosis, will be requested. The data-set will be divided into training and test/validation data-sets for model building. A predictive logistic model will be built using a training set with patients with definite TBM and no TBM. Should it be warranted, factor analysis may be employed, depending on evidence for multicollinearity or the case for including latent variables in the model. Discussion: We will systematically identify and extract key clinical parameters associated with TBM from published studies and use a ‘big data’ approach to develop and validate a clinical prediction model with enhanced generalisability. The final model will be made available through a smartphone application. Further work will be external validation of the model and test of efficacy in a randomised controlled trial.
A Structural Analysis of the Role of Superstars in Crowdsourcing Contests
Authors: Zhang Shunyuan , Singh Param Vir , Ghose Anindya 
Published: January 2019

We investigate the long-term impact of competing against superstars in crowdsourcing contests. Using a unique 50-month longitudinal panel data set on 1677 software design crowdsourcing contests, we illustrate a learning effect where participants are able to improve their skills (learn) more when competing against a superstar than otherwise. We show that an individual’s probability of winning in subsequent contests increases significantly more after she has participated in a contest with a superstar coder than otherwise. We build a dynamic structural model with individual heterogeneity where individuals choose contests to participate in and where learning in a contest happens through an information theory-based Bayesian learning framework. We find that individuals with lower ability to learn tend to value monetary reward highly, and vice versa. The results indicate that individuals who greatly prefer monetary reward tend to win fewer contests, as they rarely achieve the high skills needed to win a contest. Counterfactual analysis suggests that instead of avoiding superstars, individuals should be encouraged to participate in contests with superstars early on, as it can significantly push them up the learning curve, leading to higher quality and a higher number of submissions per contest. Overall, our study shows that individuals who are willing to forego short-term monetary rewards by participating in contests with superstars have much to gain in the long term.The online appendix is available at https://doi.org/10.1287/isre.2017.0767 .