bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do we safely preserve ovaries in patients with cervical adenocarcinoma: risk factors and predictive models
Authors: Zhang Yunqiang , Shi Yue , Xiang Xuesong , Ding Jingxin , Hua Keqin 
Published: October 2024

ObjectiveTo study and predict the risk of ovarian metastasis (OM) in patients with cervical adenocarcinoma (ADC).MethodsPatients with ADC who received surgical treatment from January 2015 to December 2022 in the Obstetrics and Gynecology Hospital of Fudan University were included in the study. Patients were further divided into OP (ovaries were preserved in surgery) and BSO (bilateral salpingo-oophorectomy) groups. For the patients who accepted BSO, 60% of the patients were randomly grouped into a training cohort, and predictive prognostic models were constructed with 10-fold cross-validation through random forest, LASSO, stepwise, and optimum subset analysis. The model with the highest area under receiver operator curve (AUC) was screened out in the testing cohort. The nomogram and its calibration curve presented the possibility of OM in future patients. The prognoses between the different populations were compared using Kaplan–Meier analysis. All data processing was carried out in R 4.2.0 software.ResultsA total of 934 patients were enrolled in our cohort; 266 patients had their ovaries preserved and 668 patients had BSO according to the previous criteria reported The clinical safety with these criteria was secured, while the 5-year overall survival had no significant difference between the BSO and OP groups (p = 0.069), which suggested that the current criteria could be extended and are more precise. Four predictive models for ovarian metastasis by machine learning were constructed in our study, and the random forest model that obtained the highest AUC in both training and testing sets (0.971 for training and 0.962 for testing set) was taken as the best model. The optimal cut-off point of the ROC curve (specificity 99.5% and 90% sensitivity) was utilized to stratify the patients into high- and low-risk OM. Further comparing the survival curves of the high and low-OM risk groups, it was found that both DFS and OS were significantly prolonged in the low-risk group (p &lt; 0.01). On the basis of this random forest model, a nomogram was used to calculate the OM risk, and the results were validated with calibration. The predictive model was further applied to the whole cohort (934 patients), and we identified the OM low-risk population (n = 822) and the patients with high risk who should be recommended for BSO (n = 112). No significant difference was found in the 5-year survival between the low-risk group with our model and the patients who already had ovaries preserved according to the previous criteria (n = 266).ConclusionThe predictive model constructed in our study could identify the low-risk population of OM in patients with ADC, which remarkably extended the number with the previous criteria, for whom we could potentially preserve ovaries to help improve their life quality.
Ectopic expression of the GRAS-type transcriptional regulator NSP2 in Parasponia triggers contrasting effects on symbioses
Authors: Alhusayni Sultan , Kersten Nick , Huisman Rik , Geurts Rene , Klein Joël 
Published: October 2024

IntroductionPlants strictly control root endosymbioses with nutrient-scavenging arbuscular endomycorrhizal fungi or nodule inducing diazotrophic bacteria. The GRAS-type transcriptional regulator NODULATION SIGNALING PATHWAY 2 (NSP2) is a conserved hub in this process. The NSP2-regulated transcriptional network is instrumental in balancing nutrient homeostasis with symbiotic interactions. NSP2 activity is modulated post-transcriptionally by a specific microRNA. Overriding this control mechanism by ectopic expression of a miRNA-resistant NSP2 transgene enhances the symbiotic permissiveness to arbuscular endomycorrhizal fungi. Such engineered plants may possess enhanced capacities for nutrient uptake. However, the trade-off of this strategy on plant development or other symbiotic interactions, like nodulation, is yet to be fully understood.MethodWe used the nodulating Cannabaceae species Parasponia andersonii as an experimental system to study the effect of ectopic NSP2 expression. Parasponia and legumes (Fabaceae) diverged 100 million years ago, providing a unique comparative system to dissect the nodulation trait.ResultsSix independent transgenic Parasponia lines were generated that differed in the level of NSP2 expression in the root from 6 to 95-fold higher when compared to the empty vector control plants. Analysis of these plants revealed a positive correlation between mycorrhization and the NSP2 expression level, as well as with the expression of the symbiosis transcription factor CYCLOPS and the rate-limiting enzyme in the carotenoid biosynthetic pathway PHYTOENE SYNTHASE1 (PSY1). Yet ectopic expression of NSP2 affected plant architecture and root nodule organogenesis.DiscussionThis indicates a significant trade-off when leveraging NSP2 over-expression to enhance endomycorrhization.
A novel mechanical-laser collaborative intra-row weeding prototype: structural design and optimization, weeding knife simulation and laser weeding experiment
Authors: Hu Rui , Niu Long-Tao , Su Wen-Hao 
Published: October 2024

IntroductionThe competition between intra-row weeds and cultivated vegetables for nutrients is a major contributor for crop yield reduction. Compared with manual weeding, intelligent robots can improve the efficiency of weeding operations.MethodsThis study proposed a novel mechanical-laser collaborative intra-row weeding device structure. A slider-crank mechanism size optimization algorithm was proposed, and the correctness of the algorithm was verified by ADMAS software. Finally, the crank and link lengths were determined to be 87 mm and 135 mm, respectively. The resistance of triangular weeding knives with different penetration angles and edge angles in the soil was simulated and analyzed using EDEM software. The simulation results show that the triangular weeding knife with a soil penetration angle of 0 ° and an edge angle of 30 ° encountered the least resistance. In addition, weed control experiments with different powers and lasers were conducted using 200 W NIR and 200 W blue lasers. The experimental results show that the time it took for a 50 W blue laser and a 100 W NIR laser to remove small weeds was approximately between 0.3 and 0.4 s, and the time it took for a 50 W blue laser to remove larger weeds was approximately between 0.5 and 0.6 s. The time it took for 75 W and 50 W NIR lasers to remove weeds was more than 1 s.ResultsBased on the above research results, a prototype of a mechanical-laser collaborative intra-row weeding device was successfully built.DiscussionThis study provides a new idea for the field of intelligent weeding. The simulation and experimental results can provide a reference for the research and development of mechanical weeding and laser weeding equipment.
The interplay of job embeddedness, collective efficacy, and work meaningfulness on teacher well-being: a mixed-methods study with digital ethnography in China
Authors: Lei Yumei 
Published: October 2024

IntroductionThis study examines the influence of teacher job embeddedness, collective efficacy, and work meaningfulness on the psychological well-being of Chinese teachers. The focus is on understanding how these constructs contribute to teacher well-being through a mixed-methods approach.MethodsA two-stage structural equation modeling (SEM) analysis was conducted using quantitative data collected from 406 in-service Chinese teachers. The study also incorporated a qualitative phase involving digital ethnography within online teaching communities to provide deeper insights into teachers’ experiences.ResultsThe quantitative analysis revealed significant positive direct effects of job embeddedness, collective efficacy, and work meaningfulness on psychological well-being, with work meaningfulness showing the strongest effect. The mediating role of work meaningfulness partially explained the relationships between job embeddedness, collective efficacy, and teacher well-being. The qualitative findings supported and expanded upon these results, emphasizing the role of a supportive school community and strong administrative leadership.DiscussionThe results suggest that enhancing job embeddedness, collective efficacy, and work meaningfulness can significantly contribute to teachers’ psychological well-being. These findings provide actionable insights for school leaders and policymakers in the Chinese educational system to foster environments that promote teacher well-being.
Research on the influence of perceived quality on users’ continuance usage intention of online live streaming class platforms: the mediating role of flow experience and the moderating impact of perceived usefulness
Authors: Wu Fan , Xie Guangying 
Published: October 2024

BackgroundWith the penetration of the “Internet+” into social life, the digitization of education has become a trend and national demand. Alongside the rise of the “Everyone Live Streaming” era, online live streaming class platforms have rapidly grown due to favorable user experiences.MethodsGrounded in the Expectation Confirmation Theory, this study employed questionnaire surveys to investigate the influence mechanism of perceived quality, flow experience, and perceived usefulness on individuals’ continuance usage intention of online live streaming class platforms.ResultsThrough the analysis of 773 survey responses, this study reveals several key findings. Firstly, perceived quality significantly and positively affects users’ intention to continue using the online live streaming class platforms. Secondly, flow experience partially mediates the relationship between perceived quality and continuance usage intention, underscoring its significance in user decision-making. Additionally, Perceived usefulness negatively moderates the relationship between perceived quality and flow experience, demonstrating varied effects.ConclusionOn the one hand, online live streaming platforms should actively invest in improving the quality of user perception, as this can lead to a better user flow experience and continued willingness to use. On the other hand, they should also pay more attention to the user’s flow experience, which has a direct impact on the user’s propensity to continue to use. Besides, the perceived usefulness of the online live class by the user should also be taken seriously.
Normative study of SATURN: a digital, self-administered, open-source cognitive assessment tool for Italians aged 50–80
Authors: Giaquinto Francesco , Assecondi Sara , Leccese Giuliana , Romano Daniele Luigi , Angelelli Paola 
Published: October 2024

IntroductionThis study aimed to establish normative data for the Self-Administered Tasks Uncovering Risk of Neurodegeneration (SATURN), a brief computer-based test for global cognitive assessment through accuracy and response times on tasks related to memory, attention, temporal orientation, visuo-constructional abilities, math (calculation), executive functions, and reading speed.MethodsA sample of 323 Italian individuals with Montreal Cognitive Assessment (MoCA) equivalent score ≥1 (180 females; average age: 61.33 years; average education: 11.32 years), stratified by age, education, and sex, completed SATURN using PsychoPy, and a paper-and-pencil protocol consisting of Mini-Mental State Examination (MMSE) and MoCA. Data analyses included: (i) correlations between the total accuracy scores of SATURN and those of MMSE and MoCA; (ii) multiple regressions to determine the impact of sex, age, and education, along with the computation of adjusted scores; (iii) the calculation of inner and outer tolerance limits, equivalent scores, and the development of correction grids.ResultsThe mean total time on tasks was 6.72 ± 3.24 min. Age and education significantly influence the SATURN total accuracy, while sex influences the total time on tasks. Specific sociodemographic characteristics influence subdomain accuracies and times on task differently. For the adjusted SATURN total score, the outer limit corresponds to 16.56 out of 29.00 (cut-off), while the inner limit is 18.57. SATURN significantly correlates with MMSE and MoCA.DiscussionIn conclusion, SATURN is the first open-source digital tool for initial cognitive assessment in Italy, showing potential for self-administration in primary care, and remote administration. Future studies need to assess its sensitivity and specificity in detecting pathological cognitive decline.
The non-linear correlation between the severity of alcohol consumption and depressive symptoms in the Chinese Wa ethnic minority
Authors: Liu Junjun , Feng Xiaotang , Liu Yang , Xiao Libin , Tong Ruixiang , Wang Yangchun , Lu Zhaomin , Jia Fengnan , Zhang Xiaobin , Li Zhe , Du Xiangdong , Yang Wanqiu 
Published: October 2024

ObjectiveThe aim of this research was to examine the association between alcohol consumption and depressive symptoms in the Wa ethnic minority of China, a population where this relationship has been insufficiently explored.MethodsA cross-sectional analysis was conducted on a sample of 317 current drinkers from the Wa ethnic minority, a “direct fast-forward” group in Cangyuan County, between December 1, 2022, and February 28, 2023. Utilizing a multi-stage cluster sampling approach, participants were selected, each of whom exhibited an Alcohol Use Disorder Identification Test (AUDIT) score exceeding 0. Data were collected via face-to-face interviews employing a uniform questionnaire. Quantification of alcohol use was achieved through the application of the AUDIT, while the Patient Health Questionnaire (PHQ)-9 was employed to gauge depressive symptoms. The relationship between the severity of alcohol consumption and depressive symptoms was evaluated using a multivariable logistic regression model. Subsequently, potential non-linear associations were scrutinized through the application of a smoothing plot.ResultsThe study included 317 current drinkers (196 males [61.83%]; mean age 41.78 ± 12.91 years), of which 94 (29.65%) exhibited comorbid depressive symptoms. Multivariable logistic regression analysis, adjusting for confounders, revealed that higher AUDIT scores were significantly associated with an increased probability of depressive symptoms (OR = 1.09, 95% CI: 1.02–1.18, p = 0.008). The risk of depressive symptoms was notably greater in the group with alcohol dependent range in contrast the group at low-risk range (OR = 7.01, 95% CI: 1.66–29.62, p = 0.008). The smoothing plot indicated a J-shaped non-linear relationship with an inflection point at an AUDIT score of 15. To the left of this inflection point, no significant relationship was observed, whereas to the right, a positive correlation emerged (OR = 1.39, 95% CI: 1.11–1.74, p &lt; 0.001).ConclusionThe findings reveal a non-linear relationship between alcohol consumption and the probability of depressive symptoms within the Wa ethnic minority in China, with implications for the development of nuanced and effective treatment strategies tailored to this population.
Impact of the COVID-19 pandemic on university students’ psychological distress, well-being, and utilization of mental health services in the United States: populations at greatest risk
Authors: Russell Elaine Cooper , Abidogun Tolulope M. , Lindley Lisa L. , Griffin Kenneth W. 
Published: October 2024

IntroductionThe COVID-19 pandemic led to major disruptions in the lives of university students, which is a population that is already at a greater risk of mental health concerns. Little is known about how the pandemic impacted distress and mental health services utilization among university students across the United States.MethodsUsing survey data from the National College Health Assessment, both before the COVID-19 pandemic (pre-March 2020, n = 88,986) and during the pandemic (Spring 2021, n = 96,489), the present study examined mental health symptoms and utilization of mental health services among undergraduate students attending four-year universities in the United States.ResultsThere were notable increases in measures of psychological distress and reductions in well-being from before the pandemic to during the pandemic. However, overall utilization rates of mental health services slightly decreased from pre-pandemic to during the pandemic. Predictors of severe psychological distress included those who experienced loneliness, COVID-19 related stressors, and loss of a loved one from COVID-19. COVID-related stressors and loneliness were associated with higher utilization rates of mental health services, while well-being and resilience were associated with lower utilization rates.DiscussionAnalyses revealed that several demographic groups were at an elevated risk for severe psychological distress, including non-binary, female, and sexual minority students, and especially those who identify as both non-binary and non-heterosexual. Results indicated that students of color, especially female students of color, were less likely to receive mental health services. Future research is needed to increase our understanding of the barriers to mental health service use among high-risk university students.
The impact of exercise self-efficacy on college students’ emotion management ability: an analysis of the mediating effects based on exercise behavior and screen media use
Authors: Zhu Weidong , Li Bo , Lou Hu , Mu Fanzheng , Liu Jun 
Published: October 2024

ObjectiveTo explore the impact of exercise self-efficacy on college students’ emotion management ability and to analyze the mediating effects of exercise behavior and screen media use between exercise self-efficacy and emotion management ability.MethodsThis study adopted stratified, whole-cluster, and staged sampling methods, using an online questionnaire that included demographic information, exercise self-efficacy, exercise behavior, screen media use, and other relevant aspects, obtaining a total of 12,687 valid questionnaires.ResultsThe study indicated a significant positive correlation between exercise self-efficacy and emotion management ability (r = 0.349, p &lt; 0.01). There was also a positive correlation between physical exercise and emotion management ability (r = 0.128, p &lt; 0.01). In contrast, smartphone use showed a significant negative correlation with emotion management ability (r = −0.102, p &lt; 0.01). Additionally, exercise persistence and electronic health literacy presented significant positive correlations with emotion management ability (r = 0.370, p &lt; 0.01; r = 0.502, p &lt; 0.01). Chain-mediated effect analysis revealed that exercise self-efficacy positively affected emotion management ability by enhancing physical exercise and reducing smartphone use (95% CI: [0.001, 0.002]). Furthermore, exercise self-efficacy positively influenced emotion management ability by enhancing exercise persistence and e-health literacy (95% CI: [0.029, 0.042]). These two variables acted as chain mediators, demonstrating the pathways through which exercise self-efficacy affects emotion management ability.ConclusionThis study deepened the understanding of the interplay between exercise behavior, screen media use, and emotion management ability. It suggested that emotion management ability could be enhanced through strategies of improving exercise persistence, physical exercise, electronic health literacy, and reducing smartphone use while considering differences in gender, academic year, and regional factors in intervention programs.
Use of autofluorescent stomatoscopy in the diagnostic algorithm for oral mucosal and vermilion border lesions in adolescents
Authors: Goryacheva T. P. , Ostrovskaya Yu. V. , Aleshina O. A. , Davydova S. I. , Goryacheva I. D. 
Published: October 2024

Relevance. There is currently significant interest in studying the prevalence of diseases affecting the oral mucosa and lip vermilion border in adolescents. A promising approach in this field is the use of modern non-invasive optical technologies, which not only offer additional insights into the patient's oral health status but also enhance their compliance.Materials and methods. A total of 71 adolescents (9th to 11th grade students) aged 15 to 17 years (mean age — 16.2 ± 0.8 years) were examined. The oral mucosa and lip vermilion border were assessed for abnormalities under natural light and through endogenous fluorescence using autofluorescent stomatoscopy. Various optical filters were applied, and clinical images were compared with autofluorescent images. A visual analog scale was used to assess the clarity of the diagnostic test results for the participant. Recommendations were provided, and treatment was prescribed according to the established diagnoses.Results. Oral mucosal lesions and lesions of the lip vermilion border were observed in 45% of cases, all of benign origin, without visible changes to the naked eye or pain. The most frequently diagnosed lesions were morsicatio buccarum and chapped lips. Distinct autofluorescent characteristics of the identified lesions were observed and documented. Participant-reported feedback was positive in 100% of cases during autofluorescent stomatoscopy. The mean score for the clarity of diagnostic results, assessed using the visual analog scale, was 9.3±0.12, indicating a high level of diagnostic visibility.Conclusion. Implementing a qualified clinical approach focused on preventing oral diseases in adolescent patients is recommended with the use of autofluorescent stomatoscopy. This technique not only offers real-time insights into the patient’s oral health status but also actively engages young patients, increasing their motivation to maintain good oral health.
ЭКОЛОГИЧЕСКИЕ (КОРРЕЛЯЦИОННЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных экологических (корреляционных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования экологических (корреляционных) исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения об экологических (корреляционных) исследованиях, и не заменяет прочтения специализированной литературы по клинической эпидемиологии.
International Kazakh - Turkish University named after K.A. Yassavy, Turkestan, Kazakhstan In this paper we present basic principles of planning and carrying out ecological (correlation) studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and effect measures calculation for ecological studies using online calculators. Examples of studies using ecological (correlation) design from international peer-reviewed literature are also presented. This article provides general introduction to ecological studies and does not substitute specialized literature in clinical epidemiology.
Осы жұмыста денсаулық сақтаудағы көлденең экологиялық(корреляциялық) жоспарлау, өткізу және статистикалық өңдеудің негізгі принциптері көрсетілген. Epi Info эпидемиологиялық мәліметтерді өңдеу үшін онлайн-калькуляторлар мен пакет көмегімен қауіп факторлары арасындағы байланысты таңдау және бағалау мөлшері есебінің практикалық мысалдары келтірілген. Авторлар әдебиеттегі көлденең экологиялық(корреляциялық) зерттеулерді пайдаланудың практикалық мысалдарын, сол сияқты осы зерттеу түрлері қасиеттері мен жетіспеушіліктерін келтіреді. Осы мақала көлденең экологилық(корреляциялық)зерттеулер туралы жалпы мәліметтер беруге бейімделген, және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқуды ауыстырмайды.