bluuebunny/crossref_metadata_2025_split huggingface dataset:
KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: protocol for a randomised controlled trial
Authors: Laslett Laura L , Antony Benny , Wluka Anita , Hill Catherine , March Lyn , Keen Helen I , Otahal Petr , Cicuttini Flavia , Jones Graeme 
Published: October 2019

Abstract
Background : Knee osteoarthritis (OA) is a common and important cause of pain and disability, but interventions aimed at modifying structures visible on imaging have been disappointing. While OA affects the whole joint, synovitis and effusion have been recognised as having a role in the pathogenesis of OA. Krill oil reduces knee pain and systemic inflammation and could be used for targeting inflammatory mechanisms of OA.
Methods : 260 patients with clinical knee OA, significant knee pain and effusion-synovitis present on MRI will be recruited in 5 Australian cities (Hobart, Melbourne, Sydney, Adelaide and Perth). They will be randomly allocated to the two arms of the study, receiving 2g/day krill oil or inert placebo daily for 6 months. MRI of the study knee will be performed at screening, and after 6 months. Knee symptoms, function and MRI structural abnormalities will be assessed using validated methods. Safety data will be recorded. Primary outcomes are absolute change in knee pain (assessed by visual analog score) and change in size of knee effusion-synovitis over 24 weeks. Secondary outcomes include improvement in knee pain over 4, 8, 12, 16 and 20 weeks. The primary analyses will be intention-to-treat analyses of primary and secondary outcomes. Per protocol analyses adjusting for missing data and for treatment compliance will be performed as the secondary analyses.
Discussion : This study will provide high-quality evidence to assess whether krill oil 2g/day reduces pain and effusion-synovitis size in older adults with clinical knee OA and knee effusion-synovitis. If krill oil is effective and confirmed to be safe, we will provide compelling evidence that krill oil improves pain and function, changes disease trajectory and slows disease progression in OA. Given the lack of approved therapies for slowing disease progression in OA, and moderate cost of krill oil, these findings will be readily translated into clinical practice.
Alcohol use, pregnancy and associated risk factors: a pilot cross-sectional study of pregnant women attending antenatal care in an urban city
Authors: Moise Imelda K 
Published: October 2019

Abstract
Background
Alcohol consumption during pregnancy is associated with adverse pregnancy outcomes such as preventable alcohol-related developmental disability fetal alcohol syndrome. In Zambia, alcohol use and associated risk factors have not been investigated, and screening in prenatal care is nonexistent. This study determined individual correlates and the prevalence of alcohol use in pregnant women attending prenatal care at two health clinics in Lusaka, Zambia.
Methods
A study adopted a cross-sectional design and recruited 188 pregnant women after seeking their informed consent from July 19 to 31, 2017. Participants aged 18 or over completed validated alcohol screening questionnaires on self-reported alcohol use periconceptional and during conception period while at their regular prenatal visit. The questionnaires included demographic questions. Bivariate analyses were performed using the χ2 test for dichotomous variables and the t-test for continuous variables. Mixed-effects linear models were used to evaluate the effect of outcome variables with patient-level variables.
Results
About 40 (21.2%) pregnant women were identified by the T-ACE as at-risk for problem drinking during pregnancy. Except for regular prenatal care and distance, there was no difference in the demographic factors between pregnant women who scored <2 on the T-ACE and those that scored > 2 points (all p’s > 0.05). A small proportional of women at both clinics reported binge drinking during the periconceptional period (12.7% vs. 3.2%, p=0.003) and beyond periconception period. Excluding employed women, no significant relationships were observed between alcohol use and demographic factors.
Conclusion
These findings underscore the need for targeted screening and intervention for alcohol use in all pregnant women in Zambia.
Factors associated with undernutrition among children with sickle cell disease attending the sickle cell clinic in Mulago National Referral Hospital, Uganda
Authors: Asiimwe Rosta , Kananura Rornald Muhumuza , Kajjura Richard , Yeka Adoke 
Published: October 2019

Abstract
Background Sickle cell disease (SCD) is among the neglected non-communicable diseases, which significantly contributes to early childhood mortality. In Uganda, over 20,000 children are estimated to be sicklers. Undernutrition is common among children with SCD and contributes to increased morbidity and mortality. There is paucity of data on prevalence of undernutrition and associated factors in Uganda. Objective To assess the extent of undernutrition and related factors among children aged 5-12 years with SCD attending the sickle cell clinic at Mulago hospital, Uganda. Methods A total of 263 children with SCD attending the sickle cell clinic at Mulago National Referral hospital were recruited consecutively between May and June 2017. The nutritional status of the children was assessed by weight-for-age, BMI-for-age, and height-for-age z-scores calculated using STATA in accordance with WHO 2007 growth standards. Binomial regression was conducted to assess the predictors of undernutrition. Results About 20.2%, 11.4%, and 13.7% of the children were underweight, wasted and stunted respectively. Wasting was significantly associated with older age (10-12 years) (AOR=4.20, CI=2.18-8.10) and living in a female headed household (AOR=0.43, CI=0.19-0.99). Stunting was significantly associated with older age (10-12 years) (AOR=2.90, CI=1.39-6.06). Underweight was significantly associated with older age (10-12 years) (AOR=2.23, CI=1.05-5.16). Conclusion Underweight, wasting and stunting were prevalent among children with SCD attending Mulago hospital. The factors associated with undernutrition were older age and living in a female headed household.
A systematic review of parent based programs to prevent or reduce alcohol consumption in adolescents
Authors: Hurley Erin , Dietrich Timo , Rundle-Thiele Sharyn 
Published: October 2019

Abstract
Background. Adolescent alcohol consumption is an issue of ongoing concern and programs targeting parents have been identified as an important component in minimizing and preventing alcohol related harm in adolescents. This paper aims to evaluate existing parent based alcohol education programs with a focus on understanding parent specific outcomes including parental attitudes, parent-child communication, alcohol specific rule setting and parental monitoring; study quality, the extent of stakeholder engagement in program design and the level of theory application.
Method. A systematic review of electronic databases EBSCO, Emerald, ProQuest, PubMed, Ovid, ScienceDirect, Taylor and Francis and Web of Science was conducted from database inception to August 2019. A total of 4288 unique records were retrieved from the eight databases. Studies were included if they evaluated school based alcohol education programs that included a parent component and detailed outcome measures associated with parent data. The methodological quality of the included studies was assessed using the Effective Public Health Practice Project (EPHPP) quality assessment tool.
Results. In total 17 studies qualified for assessment, detailing 13 individual parent programs. Of these, ten programs demonstrated positive effects in at least one parent reported outcome measure. Stakeholder engagement during the design of programs was lacking with the majority of programs. One third of the programs did not report theory use and when theory was used reporting was weak with three programs applying theory, five testing theory and none building theory. According to the EPHPP tool, overall ten programs were rated as weak, three as moderate and none as strong.
Conclusion. Future studies are recommended to further enhance the effectiveness of parental programs by improving study quality, increasing stakeholder engagement and increasing the level of theory application and reporting.
Factors associated with job satisfaction among graduate nursing faculties in Nepal
Authors: Sapkota Abja , Paudel Usha Kiran , Pokhrel Jyotsana , Ghimire Pratima , Sedhain Arun , Bhattarai Gandhi R , Thapa Binu , KC Tulza 
Published: October 2019

Abstract
Background: Job satisfaction among nursing faculty is critical to improving quality of nursing education, producing future nurses who will contribute directly to the health of patients at a local and national level. This study explores factors associated with job satisfaction among graduate nursing faculties in different universities of Nepal.
Methods: A cross-sectional study was conducted among nursing faculty with at least one year of teaching in their respective institutions. A 36-question job satisfaction questionnaire with 6-point Likert type responses was administered online. The questionnaire was pre-tested with 30 faculties pooled from multiple institutions. Link to the final survey was sent via e-mail to 327 nursing faculties working in 39 nursing colleges. Respondents were contacted by phone as a follow up to the email to politely remind them about the survey. Data analysis was carried out with SAS University Edition software. Chi-Square test and t-test were used for simple descriptive analysis. A multivariate binary logistic regression model was used to identify the significant factors associated with nursing faculties’ job satisfaction. Adjusted odds ratio was calculated and significance was considered at p ≤0.05 with 95% confidence interval.
Results: The response rate was 54.4%. After retrospective cleaning of data, usable response rate was 52.3% (n=171). The average age of the nursing faculties was 36.8±7.0 years. Based on the overall job satisfaction score, 36.8% nursing faculties were satisfied with their current job. The coefficient for Cronbach’s alpha was 0.895 suggesting very good reliability of the overall measure. The significant factors associated with job satisfaction were the involvement of the faculties in decision making process related to the department (OR=4.83) and adequate access to reference materials (OR=2.90).
Conclusions: This study suggests that nursing faculties have positive attitude towards their job but are dissatisfied with the benefits offered to them and the operating condition of their institutions. Expanding the teaching learning resources, such as reference books, subscription to journals, and continuing education opportunities for nursing faculties through participation in professional meetings would be helpful in improving the quality of nursing education in Nepal.
Influence of Selected Biomarkers on Stress and Alexithymia in Patients under Hemodialysis Treatment
Authors: Tayaz Esra , Koç Ayşegül 
Published: October 2019

Abstract
Background: Chronic renal failure causes a number of physical problems in patients. Hemodialysis treatment and the stress brought along by the treatment are high and this circumstance sets the ground for alexithymia. Alexithymic feelings basically emerge as restriction in the world of emotion and thought, and inability to recognize physiological changes. Biomarkers that are indicators of physical change are influential in the stress lives of individuals. They lead to negative changes in the physical and mental lives of patients who have chronic kidney failure and individuals who receive hemodialysis treatment. This research was carried out as a relationship seeker in order to determine the influence of urea, creatinin, sodium, potassium, hemoglobin, hematocrit, albumin, calcium, phosphorus and C-reactive protein biomarkers on stress and alexithymia in individuals, who are diagnosed with chronic renal failure and receive hemodialysis treatment.
Methods: The research environment was formed of patients who underwent hemodialysis treatment in a hospital in Turkey. The subject group was completed of 72 individuals. Demographic data form, biochemical data form, Hemodialysis Stressor Scale and Toronto Alexithymia Scale were used in the research.
Results: It was found that the levels of perceived stress of individuals who participated in the research were high at all dimensions, and 59.7% were alexithymic. The means of the total scale scores of all patients were calculated as 87.81±13.59 for HSS and 62.46±9.84 for TAS. The relationship between TAS-20 and HSS and selected biomarkers were determined (p<0.05).
Conclusion: It was concluded that stress and alexithymic feelings were high in patients who received hemodialysis treatment. It was concluded that there is a relationship between C-reactive protein, creatinin, sodium, hemoglobin, hematocrit, potassium from the biomarkers and the scales and scale sub-dimensions. It is necessary to increase the awareness of nurses on the importance of the skills to communicate with individuals who have to cope with stress, manage emotions, and have high stress and emotional deprivation.
Factors Associated With Low Handgrip Strength In The Elderly: Data Of The Study Of Chronic Diseases (Edoc-I)
Authors: Amaral Cledir de Araújo , Amaral Thatiana Lameira Maciel , Monteiro Gina Torres Rego , de Vasconcellos Mauricio Teixeira Leite , Portela Margareth Crisostomo 
Published: October 2019

Abstract
Background Handgrip strength (HGS) is a recognized important health biomarker, whose low scores have showed an evident association with morbimortality of adults and elderly people from various parts of the world. This study aimed to analyze the factors associated with low HGS in elderly persons in Rio Branco, Acre, Brazil.Methods The study was carried out with data from the Study of Chronic Diseases (EDOC-I) – Elderly, performed with 1,016 people aged over 60 residing in Rio Branco. Associations between variables of health status (psychological and physical) and low HGS, by sex, were estimated using logistic regression.Results The reduction of the median HGS ​​was 6.0 kg per decade among men, and 2.6 kg among women. A greater reduction was observed in the lower quintile of HGS of women aged over 80 years, 4.1 kg in relation to the previous decade. Factors independently associated with low HGS in men and women, respectively, were low weigh in BMI [OR 2.80 (1.22-6.44) and OR 2.61 (1.49-4.57)], anemia [OR 4.15 (2.14-8.04) and OR 1.80 (1.08-3.01)] and diabetes as a risk factor in men [OR 1.95 (1.02-3.73)] and as protection factor in women [OR 0.53 (0.28-0.99)]. There was a higher chance of low HGS in men with partners [OR 2.44 (1.35-4.42)], smokers or former smokers [OR 3.25 (1.29-8.19)], with current self-assessment of health worse than the 12 previous months [OR 2.21 (1.16-4.21)] and dependence in ADL [OR 2.92 (1.39-6.15)]. Only among women, there was an increased chance of low HGS associated with altered WHR [OR 1.79 1.04-3.07)], insomnia [OR 1.83 (1.12-2.98)] and physical activity from displacement/occupation [OR 1.75 (1.10-2.80)]Conclusion Factors associated with low HGS are not common to gender and the inclusion of HGS as a component of health seems to be a promising strategy for disease prevention and health promotion.
Epidemiology of intestinal parasitic infections in Ethiopian children: A systematic review and meta-analysis
Authors: Mekonnen Zeleke , Alemu Yonas , Emana Daniel , Chelkeba Legese 
Published: October 2019

Abstract
Background : Numerous studies have been carried out on assessing the prevalence of intestinal parasites infections (IPIs) among preschool and school age children in Ethiopia, however, there was no study to gather and systematically analyze this information for policy makers. Methods : We searched Medline via PubMed, Scopus, Science Direct, Web of Science (ISI), and Google Scholar and local peer-reviewed journals published from inception to 2019 for studies describing prevalence of IPIs among preschool and school age children. We conducted meta-regression to understand the trend and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software (Intercooled, version 14, STATA Corp, College Station, TX). Results : Eighty three (83) studies examining 56,786 fecal specimens were included. The prevalence of IPIs was 48 %( 95%CI: 42% to 53%) and showed a gradual, but significantly decreasing trends 17% (95% CI: 2.5% to 32%) for each consecutive 6 years) and was similar in males and females. The pooled prevalence in years 1997–2002, 2003–2008, 2009–2014 and >2014 was 71% (95% CI: 57% to 86%), 42% (95% CI: 27% to 56%), 48% (95% CI: 40% to 56%) and 42% (95% CI: 34% to 49%), respectively. Poly-parasitism was observed in 16% (95% CI: 13% to 19 %,) of children while, single parasite infection was observed in 36 %( 95% CI: 30% to 41%). Conclusion: IPIs are highly prevalent and well distributed across the regional states of Ethiopia. Southern and Amhara regional states carry the highest burden. We observed a gradual, but significant decreasing trends in prevalence of IPIs among Ethiopian children over the last two decades.
A mixed methods systematic review of the effects of patient online self-diagnosing in the 'smart-phone society' on the healthcare professional-patient relationship and medical authority
Authors: Farnood Annabel , Johnston Bridget , Mair Frances S 
Published: October 2019

Abstract
Background: As technology continues to advance, the internet is becoming increasingly popular. Self-diagnosis and health information seeking online is growing more common and it will be important to understand the influence this may have on the patient-healthcare professional relationship. Methods: A mixed-method systematic review of quantitative, qualitative and mixed method studies concerning the public and healthcare professionals’ perceptions of online self-diagnosis and health information seeking and how this can impact the patient-healthcare professional relationship. We searched MEDLINE, EMBASE, CINAHL, ACM & SCOPUS between 2007 and 2018. Relevant data were extracted, and a thematic analysis was conducted and conceptualised using the Normalisation Process Theory framework. Results: Of 6107 records identified, 25 articles met the review eligibility criteria which included 16 qualitative, 8 quantitative and 1 mixed method study. The findings indicated that patients found the internet as a complementary information source alongside healthcare professionals. Health care professionals were perceived to be the most reliable and valued information source. People feel responsible for their own health and find the internet to be a source that provides information rapidly with accessibility at their convenience. Most healthcare professionals agreed on the importance of collaboration with patients and the need to develop a partnership and shared decision-making process but struggled to find time in the consultation to do so efficiently. Some healthcare professionals felt that the internet was advantageous for patients looking after their own health, while others felt it was due to a lack of trust in their expertise. Patients tended to present information to the healthcare professional to support the therapeutic relationship rather than to challenge it and to become more involved in the decision-making process of their healthcare. Conclusion: The results of this review suggests that patients value healthcare professionals as a source of medical advice more than the internet. While health professionals views were mixed our findings indicate that online health information seeking can potentially improve the patient-healthcare professional relationship as patients reported they usually conducted an online search to form a partnership with the healthcare professional as opposed to trying to prove them wrong. Systematic review registration: CRD42018084230
Satisfaction with clinical practice among nursing students using regression models and qualitative comparative analysis
Authors: Fernández-García David , Moreno-Latorre Esther , Giménez-Espert María del Carmen , Prado-Gascó Vicente Javier 
Published: October 2019

Abstract
Background: Clinical practices are considered fundamental in nursing studies for effective training of nurses and in students’ satisfaction. Both the clinical environment and the clinical educator are key factors in satisfaction with the clinical practice. The aim of this study was to analyse the influence of the socio-demographic variables of clinical educators and nursing students on satisfaction with the clinical practices.Methods: The study included 527 nursing students enrolled on the subject of clinical practice at a private university in Valencia, Spain. The age of the participants ranged from 19 to 51 years old, (M=24.4; SD=6.1) and 79% (451) were women. An instrument was used to measure satisfaction with the practices based on the following scales: Clinical Learning Environment (CLE-1995), Clinical Learning Environment and Supervision (CLES-2002), Clinical Learning Environment Inventory (CLEI-2003), Clinical Learning environment, supervision and nurse teacher (CLES+T - 2008) and the Clinical Assessment Instrument (IEC-2009). Two statistical methodologies were used for data analysis: hierarchical regression models (HRM) and fuzzy-set qualitative comparative analysis model (fsQCA).Results : The results indicate that sociodemographic variables such as sex and year group influence student satisfaction in both methodologies. Conclusions: Based on these results, training plans to improve students’ satisfaction with the clinical practice can be established.
Status and manifestations of sleep disorders and the status of drugs used to help fall sleep in Chinese breast cancer women at initial diagnosis and during chemotherapy
Authors: Zou Baoshan , Li Hong , Liu Jiashuo , Xu Zhou , Chen Haoran , Li Hao , Wu Kainan , Kong Lingquan 
Published: October 2019

Abstract
Purpose This study was designed to investigate the status and manifestations of sleep disorders and the status of drugs used to help fall sleep in Chinese breast cancer women at initial diagnosis and during chemotherapy. Patients and Methods Totally 308 primary breast cancer women were enrolled. The status and manifestations of sleep disorders and the status of drugs used to help fall sleep in the above breast cancer patients were assessed via the Pittsburgh Sleep Quality Index (PSQI). Result The prevalence of sleep disorders in patients at the time of initial diagnosis with breast cancer was approximately 50% (97/194), which was significantly lower than that (65.8%, 75/114) in breast cancer patients before the last cycle of chemotherapy (p＜0.05) . However, both groups of patients rarely used drugs to help them fall sleep (P>0.05). The mean scores for sleep latency, habitual sleep efficiency, sleep disturbance, and daytime dysfunction (1.68, 1.08, 1.65, 1.37) in breast cancer patients prior to the last cycle of chemotherapy were obviously worse than those (1.29, 0.71, 1.26, 1.01) in breast cancer patients at the time of initial diagnosis (p<0.05). Conclusion Chemotherapy mainly affects the sleep latency, habitual sleep efficiency, sleep disturbance, daytime dysfunction in breast cancer patients. Chinese breast cancer patients rarely use drugs to intervene sleep disorders.