bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROCK inhibitor enhances the growth and migration of BRAF‐mutant skin melanoma cells
Authors: Chang Fei , Zhang Yunpeng , Mi Jun , Zhou Qian , Bai Fuxiang , Xu Xin , Fisher David E. , Sun Qinfeng , Wu Xunwei 
Published: August 2018

Rho‐associated protein kinase (ROCK) plays crucial roles in the proliferation and migration of different types of cells. ROCK inhibitor Y‐27632 was previously reported to inhibit melanoma cell growth, and ROCK signaling was suggested to be a therapeutic target for treating melanoma. However, the negative effect of Y‐27632 on melanoma cells was mainly seen in studies on murine B16 melanoma cells. Here, we reported that ROCK inhibitor actually promoted human melanoma cell growth and migration in vitro. Y‐27632 increased the growth and migration of BRAF‐mutated melanoma cells but had a negative effect on wild‐type melanoma cells or primary melanocytes. We discovered that Y‐27632 enhanced the growth of BRAF‐mutated melanoma cells through increased ATK and ERK activity. The in vivo study further confirmed the in vitro finding. These data suggested that the effect of ROCK inhibitor on melanoma cells is cell‐context dependent, and the application of ROCK inhibitor in the treatment of melanoma requires further study.
Attachment Disorganization in Infancy: A Developmental Precursor to Maladaptive Social Information Processing at Age 8
Authors: Zajac Lindsay , Bookhout Megan K. , Hubbard Julie A. , Carlson Elizabeth A. , Dozier Mary 
Published: August 2018

This study examined infant attachment as a predictor of social information processing (SIP) in middle childhood (n = 82) while controlling for parental sensitivity in middle childhood. Attachment quality was assessed using the Strange Situation. Although attachment insecurity did not predict SIP, attachment disorganization positively predicted the early SIP steps of hostile attributional bias and aggressive goals. Children with disorganized attachments interpreted ambiguous provocations more negatively (as indicating more hostility, rejection, and disrespect and as resulting in more anger) and endorsed significantly more revenge and dominance goals than children with organized attachments. In contrast, parental sensitivity negatively predicted the later SIP step of positive expectations for aggressive responses. Results further our understanding of the adverse outcomes associated with attachment disorganization.
Retinal imaging including optical coherence tomography angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum
Authors: Birtel Johannes , Lindner Moritz , Mishra Divyansh K. , Müller Philipp L. , Hendig Doris , Herrmann Philipp , Holz Frank G. , Fleckenstein Monika , Gliem Martin , Charbel Issa Peter 
Published: August 2018

ImportanceThe diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but is currently poorly understood.BackgroundOptical coherence tomography (OCT), fluorescein angiography (FA) and OCT angiography (OCT‐A) are employed in daily practice, but a systematic comparison of these imaging techniques is lacking.DesignRetrospective, observational study.ParticipantsTwenty patients (31 eyes) with PXE.MethodsOCT, FA and OCT‐A imaging was performed in each eye and graded separately by independent readers.Main Outcome MeasuresDiagnostic accuracy, sensitivity and specificity to detect CNV‐activity of each modality and longitudinal change of CNV size measured by OCT‐A.ResultsOCT showed the highest diagnostic accuracy (kappa = 0.57) in comparison to OCT‐A or FA (kappa = 0.39 and 0.37, respectively). OCT‐A, OCT and FA showed a diagnostic sensitivity of 0.9, 0.85 and 0.6, and a diagnostic specificity of 0.45, 0.72 and 0.82, respectively. Evaluation of longitudinal OCT recordings (24 eyes) resulted in optimal sensitivity and specificity (kappa = 1.0). Although median CNV size assessed using OCT‐A remained stable on longitudinal measures of seven eyes, two eyes showed a distinct increase over time despite anti‐vascular endothelial growth factor treatment.Conclusions and RelevanceThe systematic use of OCT, FA and OCT‐A imaging can facilitate the diagnostic accuracy for detection and follow‐up of CNV activity in PXE. While structural OCT is of high value, especially when longitudinal follow‐up images are available, FA and OCT‐A data might contribute to diagnostic accuracy in more complex cases.
Does intraoperative perforation of Schneiderian membrane during sinus lift surgery causes an increased the risk of implants failure?: A systematic review and meta regression analysis
Authors: Al‐Moraissi Essam , Elsharkawy Ahmed , Abotaleb Bassam , Alkebsi Khaled , Al‐Motwakel Hamza 
Published: August 2018

AbstractPurposeThere is still debate whether intraoperative Schneiderian membrane (SM) perforation in the maxillary sinus lift causes an increase the risk of implants failure. The aim of this study was to assess an association between SM perforation and implants loss following the maxillary sinus lift.Materials and methodsA systematic review and meta‐analysis of clinical studies assessing association between SM perforation and implants failure based on PRISMA was conducted. Three major databases were used to gather research dating from their respective inception up until March 2018. All clinical studies expressly reported the number of the SM perforation and implants loss that installed in the perforated and nonperforated sinuses were included. The statistical analyses used were Pearson's correlation, simple linear regression, and meta regression. The risk ratio (RR) of implant loss between perforated and nonperforated sites was estimated.ResultsA total of 2947 patients with 3884 maxillary sinuses augmentations who received 7358 implants, enrolled in 58 studies were included in this study. There was a significant relationship between the implants' failure and SM perforation according to simple linear regression (P < .001) and meta regression analysis (P = .06). There was a significant decrease (moderate quality evidence) in implant loss in the nonperforated sinuses compared to perforated sunrises (RR = 2.17, CI: 1.52‐3.10, P = .001). There was also no significant association between implant loss in the perforated sinuses and the surgical devices used (piezosurgical or rotary), surgical approach applied (lateral or crestal sinus lift), barrier membrane used and type of bone grafting materials.ConclusionThe results of this study showed that an intraoperative SM perforation could increase the risk of implant failure after the sinus lift surgery.
Competition and collaboration between public and private sectors: the historical construction of the Spanish hospital system, 1942–86
Authors: Vilar‐Rodríguez Margarita , Pons‐Pons Jerònia 
Published: August 2018

AbstractThroughout history, healthcare, along with diet, has been an essential component of life and a country's welfare. In particular, a country's hospital system is a key indicator for analysing the level of welfare achieved by health coverage. From an economic history perspective, the study of hospital systems is relevant since they stem from public and private investment and produce positive externalities by creating employment and stimulating other economic sectors such as construction and health. Spain provides a significant case study for determining the factors of backwardness in the construction of a modern hospital system in a country on the European periphery. Moreover, it also helps us understand how, despite initial obstacles, this system had attained a significant degree of quality by the end of the twentieth century, as confirmed by its current international hospital rankings and even by the phenomenon of health tourism. The study analyses the creation of the Spanish hospital system during Franco's dictatorship and the transition to democracy. It reveals how the maintenance of a regressive tax system, the use of health policy as political propaganda, and disputes within the political elite of the dictatorship led to an inadequate and fragmented public hospital system, which had to collaborate with the private hospital system, was full of financial holes and tainted by corruption, and remained at the service of privileged groups.
One device does not fit all: Limited results of using a Sort‐X grid in the multi‐species trawl fishery in the Gulf of Cádiz
Authors: Gamaza MariÁngeles , Fonseca Paulo , Campos Aida , Erzini Karim , Sobrino Ignacio 
Published: August 2018

AbstractA Sort‐X grid device with four different bar‐spacing grids (25, 30, 40 and 50 mm) was tested in the Gulf of Cádiz (GoC) on‐board commercial trawlers. A total of 83 fish, five crustacean and nine cephalopods species were sampled in 282 hauls. Most of the target and commercial bycatch species were sorted out by the grid with the exception of hake. Merluccius merluccius (L.). Additionally, common pandora, Pagellus erythrinus (L.), sardine, Sardina pilchardus (Walbaum), octopus, Octopus vulgaris Lamark, and cuttlefish, Sepia officinalis L., also showed a sizeable retention for some of the grid bar spacing. Statistical modelling of selectivity at length for hake found influence of depth on the selection parameters. Lengths at 50% retention for hake were estimated to be 27.4, 30.3, 36.3 and 42.3 cm TL for 25–50 mm bar spacing, respectively, all above the minimum conservation reference size (MCRS) in the GoC. The probability of hake contacting the grid was estimated as 0.95. Overall, although the selective device showed a good performance for hake, it is not appropriate for improving the fishing pattern of a multi‐species trawl fishery such as that of the GoC.
Clinical features and outcomes in patients with elderly‐onset anti‐neutrophil cytoplasmic antibody‐associated vasculitis
Authors: Sato Shuzo , Yashiro Makiko , Matsuoka Naoki , Asano Tomoyuki , Kobayashi Hiroko , Watanabe Hiroshi , Migita Kiyoshi 
Published: August 2018

AimAnti‐neutrophil cytoplasmic antibody‐associated vasculitis (AAV) is commonly seen in older patients. The present study intended to clarify whether elderly‐onset AAV (at age ≥75 years) shows any specific clinical features and outcomes in Japanese patients.MethodsThis study was a retrospective cohort study. A total of 36 AAV patients who were initially treated at the Department of Rheumatology, Fukushima Medical University Hospital (Fukushima, Japan) between 2004 and 2016 were included. AAV patients were divided into an elderly group (≥75 years) and a younger group (<75 years), and their clinical records were reviewed.ResultsElderly AAV patients showed similar clinical features to younger AAV patients, except that they were more often women, weighed less, had an increased frequency of kidney involvement and had lower serum ferritin levels. Kaplan–Meier analyses showed significantly lower 1‐year survival in elderly AAV (P =0.008) as well as AAV patients enrolled not receiving additional immunosuppressive treatment (P =0.023). The cause of death was disease progression itself or infection.ConclusionsThe clinical features of AAV are similar between elderly and younger patients, except for increased kidney involvement and lower serum ferritin levels. Proper monitoring of the disease and adverse events, and providing conventional immunosuppressive therapy is suggested to avoid a poor outcome, especially in elderly AAV patients. Geriatr Gerontol Int 2018; 18: 1453–1457.
LATE CAREER JOB LOSS AND THE DECISION TO RETIRE
Authors: Merkurieva Irina 
Published: August 2018

AbstractThis article provides an empirical analysis of the effect of involuntary job loss on the lifetime income and labor supply of older workers. I develop and estimate a dynamic programming model of retirement with savings, costly job search, and exogenous layoffs. The average cost of job loss is equivalent to one year of predisplacement earnings, 70% due to the wage reduction and 30% to the search frictions. Displaced workers on average retire 14 months earlier. Workers who approached retirement during the Great Recession will work approximately five months longer in response to the contemporaneous financial and labor market shocks.
Self‐care of patient and caregiver DyAds in multiple chronic conditions: A LongITudinal studY (SODALITY) protocol
Authors: De Maria Maddalena , Vellone Ercole , Ausili Davide , Alvaro Rosaria , Di Mauro Stefania , Piredda Michela , De Marinis Mariagrazia , Matarese Maria 
Published: August 2018

AbstractAimTo describe a research protocol for a study designed to examine self‐care in patient and caregiver dyads in coping with multiple chronic conditions, to evaluate the influence of dyad self‐care on: (a) patient mortality, quality of life, hospital admissions, and the unplanned access of care; and (b) the positive aspects of caregiving. The specific conceptual framework that we developed for this study considers the predictors of self‐care (at patient, caregiver, and dyadic levels), the process of self‐care and the outcomes of self‐care in patient and caregiver dyads with multiple chronic conditions. These elements in patient and caregiver dyads have not been well‐studied to date.DesignThis is a multicentre longitudinal study with data collection at 0, 6, and 12 months.MethodsWe will use generic and specific tools to assess the predictors of self‐care, the process of self‐care and the outcomes of self‐care in the dyads. The data will be analysed with descriptive and inferential statistics and multilevel modelling to control for the interdependent nature of dyadic data. The study was approved by an ethics committee and was funded by a grant from the Centre of Excellence for Nursing Scholarship Rome, in November 2015.DiscussionThis study seeks to determine the predictors and outcomes of self‐care in patient and caregiver dyads within the context of multiple chronic conditions.ImpactThe results of this study will inform clinical practice and research by identifying variables that are modifiable and therefore amenable to interventions.
Key components of knowledge transfer and exchange in health services research: Findings from a systematic scoping review
Authors: Prihodova Lucia , Guerin Suzanne , Tunney Conall , Kernohan W. George 
Published: August 2018

AbstractAimsTo identify the key common components of knowledge transfer and exchange in existing models to facilitate practice developments in health services research.BackgroundThere are over 60 models of knowledge transfer and exchange designed for various areas of health care. Many of them remain untested and lack guidelines for scaling‐up of successful implementation of research findings and of proven models ensuring that patients have access to optimal health care, guided by current research.DesignA scoping review was conducted in line with PRISMA guidelines. Key components of knowledge transfer and exchange were identified using thematic analysis and frequency counts.Data SourcesSix electronic databases were searched for papers published before January 2015 containing four key terms/variants: knowledge, transfer, framework, health care.Review MethodsDouble screening, extraction and coding of the data using thematic analysis were employed to ensure rigour. As further validation stakeholders’ consultation of the findings was performed to ensure accessibility.ResultsOf the 4,288 abstracts, 294 full‐text articles were screened, with 79 articles analysed. Six key components emerged: knowledge transfer and exchange message, Stakeholders and Process components often appeared together, while from two contextual components Inner Context and the wider Social, Cultural and Economic Context, with the wider context less frequently considered. Finally, there was little consideration of the Evaluation of knowledge transfer and exchange activities. In addition, specific operational elements of each component were identified.ConclusionsThe six components offer the basis for knowledge transfer and exchange activities, enabling researchers to more effectively share their work. Further research exploring the potential contribution of the interactions of the components is recommended.
Long‐term outcomes of catheter ablation in patients with longstanding persistent atrial fibrillation lasting less than 2 years
Authors: Della Rocca Domenico G. , Mohanty Sanghamitra , Mohanty Prasant , Trivedi Chintan , Gianni Carola , Al‐Ahmad Amin , Burkhardt J. David , Gallinghouse G. Joseph , Hranitzky Patrick , Sanchez Javier E. , Horton Rodney P. , Di Biase Luigi , Natale Andrea 
Published: August 2018

AbstractIntroductionOutcome data after catheter ablation (CA) for longstanding persistent atrial fibrillation (LSPAF) lasting less than 2 years are limited and highly variable with different ablation approaches. We aimed to assess the long‐term outcomes in patients with LSPAF lasting less than 2 years undergoing extended pulmonary vein antrum isolation (PVAI) versus those with additional non‐pulmonary vein (PV) trigger ablation.Methods and ResultsIn this prospective analysis, 381 consecutive patients with LSPAF lasting less than 2 years (age: 64 ± 9 years, 76% male, atrial fibrillation duration: 19 ± 5 months) undergoing their first CA were classified into two groups: Group 1 (n = 104) received PVAI extended to PW plus isolation of superior vena cava (SVC) and Group 2 (
n = 277) received PVAI + PW + SVC + non‐PV–trigger ablation. All patients were followed‐up for at least 2 years. In case of recurrence, repeat procedure was offered and non‐PV triggers were targeted for ablation in all.After a single procedure, 26 (25%) patients in Group 1 and 172 (62.1%) in Group 2 remained arrhythmia‐free (P < 0.001). A second procedure was performed in 58 of 78 (74.4%) patients in Group 1 and 77 of 105 (73.3%) patients in Group 2. Non‐PV triggers were identified in 52 (89.6%) and 54 (70.1%) patients in Groups 1 and 2, respectively, and targeted for ablation. Overall, 72 (69.2%) patients in Group 1 and 238 (86%) in Group 2 remained arrhythmia‐free (
P < 0.001).ConclusionIn patients with LSPAF lasting less than 2 years, extended PVAI plus SVC isolation was less likely to achieve long‐term sinus rhythm. In the majority of patients, recurrence was due to non‐PV triggers and ablation of those resulted in better outcome.
Health‐related quality of life impact of a transcatheter pacing system
Authors: Tjong Fleur V. Y. , Beurskens Niek E. G. , de Groot Joris R. , Waweru Catherine , Liu Shufeng , Ritter Philippe , Reynolds Dwight , Wilde Arthur A. M. , Knops Reinoud E. ,   For the Micra Investigators
Published: August 2018

AbstractBackgroundTranscatheter pacing systems (TPS) provide a novel, minimally invasive approach in which a miniaturized, leadless pacemaker (PM) is transfemorally implanted in the right ventricle. We evaluated the health‐related quality of life (HRQoL) impact, patient satisfaction, and activity restrictions following TPS in a large prospective multicenter clinical trial.Methods and ResultsPatients who underwent a Micra TPS implantation between December 2013 and May 2015 were included. HRQoL impact was evaluated using the Short‐Form‐36 (SF‐36) questionnaire at baseline, 3, and 12 months. Patient satisfaction was assessed using a three‐item questionnaire determining recovery, activity level, and esthetic appearance at 3 months. Implanting physicians compared the patient activity restrictions for TPS to traditional PM therapy. A total of 720 patients were implanted with a TPS (76 ± 11 years; 59% male). Of these patients, 702 (98%), 681 (95%), and 635 (88%) completed the SF‐36 at baseline, 3 and 12 months, respectively. Improvements were observed at 3 and 12 months in all SF‐36 domains and all attained statistical significance. Of 693 patients who completed the patient satisfaction questionnaire, 96%, 91%, 74% were (very) satisfied with their esthetic appearance, recovery, and level of activity, respectively. TPS discharge instructions were rated less restrictive in 49%, equally restrictive in 47%, and more restrictive in 4% of cases compared with traditional PM systems.ConclusionsTPS resulted in postimplant HRQoL improvements at 3 and 12 months, and high levels of patient satisfaction at 3 months. Further, TPS was associated with less activity restrictions compared with traditional PM systems.
Health beliefs and behaviours of families towards the health needs of children with intellectual and developmental disabilities (IDD) in Accra, Ghana
Authors: Lamptey D.‐L. 
Published: August 2018

AbstractBackgroundThis paper explored the health beliefs and behaviours of families towards the health needs of children with intellectual and developmental disabilities (IDD) in Accra, Ghana. The aim was to inform health promotion strategies for the children and their families.MethodTwenty‐two parents of children with IDD participated in this study. Semi‐structured interviews were the primary means of data collection. The interviews were analysed using constant comparison.ResultsThe signs that alerted the parents that the children might be ill included high temperature, vomiting and excessive sleep. The parents explained that some children expressed feelings of ill‐health through verbal or non‐verbal communication. Most of the parents self‐prescribed medication for the children or waited for symptoms to persist for a while before accessing health care because they experienced difficulties managing the behavioural challenges associated with the IDD of the children in public and attitudinal barriers when accessing health care. The parents did not often patronise health facilities in their neighbourhoods due to private health insurance requirements for accessing care at designated facilities, poor confidence in neighbourhood facilities and long‐term established relationships with facilities elsewhere. Further, many parents did not patronise religious interventions for the children. However, some parents explained that in addition to seeking medical care to address the physical symptoms of the children's disabilities and/or illnesses, they sought religious interventions because they believed that there could be a spiritual dimension to the situation.ConclusionThe findings highlight key areas to address in health promotion for children with IDD and their families in Accra, Ghana.