bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trunnion corrosion in metal-on-polyethylene hip arthroplasty
Authors: Lachiewicz P. F. , O’Dell J. A. 
Published: June 2018

Aims To report our experience with trunnion corrosion following metal-on-polyethylene total hip arthroplasty, in particular to report the spectrum of presentation and determine the mean time to presentation. Patients and Methods We report the presenting symptoms and signs, intraoperative findings, and early results and complications of operative treatment in nine patients with a mean age of 74 years (60 to 86). The onset of symptoms was at a mean of seven years (3 to 18) after index surgery. Results Patients presented with a variety of symptoms including pain, limp and rash. The preoperative mean serum cobalt level was 7.1 ppb (2.2 to 12.8) and mean serum chromium level was 2.2 ppb (0.5 to 5.2). Metal artifact reduction sequence (MARS) MRI showed fluid collection and possible pseudotumour formation in five hips, fluid collection in two hips, and synovitis/debris in one hip, with no MRI in one patient. Acetabular revision was performed in three patients, six patients underwent liner and head exchange only. The postoperative metal levels decreased in all patients: mean cobalt 0.5 ppb (0 to 1.8) and mean chromium 0.9 ppb (0 to 2.6) at a mean of five months (3 to 8) postoperatively. Seven patients had good pain relief and no complications at one year. There were two major complications requiring reoperation: acute infection at six weeks, for which the patient required two-stage reimplantation; and recurrent dislocation, for which the patient was revised to a dual mobility component. Conclusion Trunnion corrosion in metal-on-polyethylene THA has a range of presenting symptoms, and may present later than previously described. A high index of suspicion is warranted, and serum cobalt and chromium levels are recommended for diagnosis. Patients should be counselled about possible postoperative complications. Cite this article: Bone Joint J 2018;100-B:898–902.
AVALIAÇÃO HIGIÊNICO-SANITÁRIA DE CARNE MOÍDA COMERCIALIZADA EM AÇOUGUES DA CIDADE DE SARANDI, PR, BRASIL
Authors: De Almeida Caroline Rodrigues , Massago Miyoko , Boni Sara Macente 
Published: July 2018

O consumo de carne bovina pela população brasileira tem aumentado nos últimos anos. No entanto, o processamento deste produto pode favorecer a sua contaminação por microrganismos e desencadear surtos de infecção alimentar. Baseado nestas informações, o objetivo do presente trabalho foi avaliar a qualidade higiênico-sanitária da carne moída comercializada em 20 açougues da cidade de Sarandi, PR. Foram coletadas amostras de 50 gramas do produto em cada estabelecimento. Em seguida foi verificada a presença de coliformes totais e termotolerantes pela Técnica do Número Mais Provável e de Salmonella spp. por crescimento em meio específico. Foi observada a presença de coliformes termotolerantes em todas as amostras analisadas; porém, em nenhuma delas houve o crescimento de Salmonella spp. A presença de Escherichia coli no alimento indica falha nos procedimentos higiênico-sanitários, ressaltando a importância de implementar medidas que promovam melhoria nas boas práticas de higiene, a fim de reduzir os índices de contaminação destes produtos e aumentar a qualidade de vida do consumidor.
MORFOLOGÍA VEGETAL COMO HERRAMIENTA PARA LA IDENTIFICACIÓN DE ADULTERANTES EN LOS FRUTOS COMERCIALIZADOS COMO “anís verde”, Pimpinella anisum L. (Apiaceae)
Authors: González Yenny , Degen de Arrua Rosa 
Published: July 2018

El Paraguay es un país caracterizado por una población que consume en gran medida plantas medicinales para el tratamiento de diversas afecciones. Sin embargo, en nuestro país no hay un legislación bien definida respecto al control de este tipo de productos y, dentro de este contexto surge la interrogante: sabe la población lo que está consumiendo?. Esto, crea un terreno fértil para la adulteración y sustitución de todo tipo. El presente trabajo se desarrolló dentro del marco del Proyecto: “Identificación de adulterantes y materias extrañas en frutos medicinales, comercializados en principales herboristerías de Asunción y Gran Asunción, como aporte para el control de calidad de drogas vegetales”, financiado por el Rectorado de la Universidad Nacional de Asunción, y tuvo como objetivo, determinar la presencia de adulterantes en los frutos comercializados como “anís verde”, Pimpinella anisum L., en las principales herboristerías de Asunción y Gran Asunción, empleando la morfología vegetal como herramienta. Para ello se adquirieron las muestras de los frutos de “anís verde” de las herboristerías, y luego fueron analizadas en el laboratorio. Como resultado se identificaron en total dos especies adulterantes del “anís verde”: semillas de sésamo, Sesamun indicum y frutos de “kuratú”, Coriandrum sativum; todas las muestras presentaron en su composición alguno de estos adulterantes o incluso ambos, sin embargo, todas se comercializan a diferentes precios, algunas incluso al triple del valor que otras. De esta manera, el análisis morfológico, permite aportar datos útiles a la hora de realizar el control de calidad de drogas vegetales, de manera a brindar a la población, seguridad en lo que está consumiendo.
THE POPULARIZATION OF ORODISPERSIBLE TABLETS IN THE PHARMACEUTICAL MARKET
Authors: Pinho Ludmila Alvim , Temer Ana Claudia , Ribeiro Caroline , Sá-Barreto Livia Lira , Cunha-Filho Marcilio Sergio Soares 
Published: July 2018

Orodispersible tablets are getting popular due to its easy administration which leads to a higher therapeutic adherence. This study aimed to evaluate the state of the art of these drug products based on the scientific literature. Also, orodispersible tablets available in the US, Europe and Brazil markets based on information extracted from the health agencies were analyzed. Those tablets are designed to be placed on the tongue and instantly disintegrated by the fast capitation of the saliva without the additional intake of water. The orodispersible technology enables oral administration of tablets to patients with dysphagia, especially children, and elderlies. Moreover, orodispersible make possible rapid drug intervention and mouth absorption. The drug is partially absorbed in the oral cavity, pharynx, and esophagus without first pass effect, increasing drug bioavailability and reaching faster therapeutic effect. This is a low-cost technology that fits in a conventional solid production area and adds value to the product without requiring high investment. A market analysis showed there is a predominance of antihistamine drugs or medicines for mental disorders using orodispersible matrices. However, the orodispersible technology shows great versatility and potential application to other pharmacological groups. It is expected that in coming years a massive commercial insertion of this tablet technology occurs. In this scenery, it is indispensable that health professionals are prepared with updated technical information for the use of this therapeutic resource safely and efficiently.
MELASMA: TRATAMENTO E SUAS IMPLICAÇÕES ESTÉTICAS
Authors: Barbosa Kledson Lopes , Guedes Monique Ribeiro Mota 
Published: July 2018

O melasma faz parte de um fenômeno biológico, desenvolvido a partir da exposição aos raios UV, uso de hormônios exógenos, fatores genéticos, e fármacos que causam fotossensibilização. Sabe-se que a incidência ocorre principalmente em mulheres em idade fértil. A hiperpigmentação trata-se de uma doença da pele que surge após lesão cutânea em decorrência de uma reação inflamatória. Por ser - o melasma e a hiperpigmentação - duas condições relativamente frequentes, e pela frequência com que ressurgem após o tratamento, é de extrema importância conhecê-las a fim de se obter informações relevantes para um tratamento eficaz e sem recidiva. Nesse sentido, o objetivo deste estudo foi realizar uma revisão de literatura sobre melasma e hiperpigmentação contemplando a fisiopatologia e os principais tratamentos utilizados. Para isto, foi desenvolvido uma pesquisa qualitativa de cunho exploratório-descritivo realizada em periódicos internacionais no período de novembro de 2016 a abril de 2017. Os protocolos de tratamento progrediram nos últimos anos, entretanto, o conhecimento da real patogênese do melasma continua insatisfatório e que agentes tópicos e os sistemas que utilizam laser, por vezes induzem a melhora da pigmentação e não a eliminaçãototal da lesão.
Is skepticism an epistemological predicament? <p>Skeptisizm epistemolojik bir çıkmaz mıdır?
Authors: Öztanrıkulu Özel Nurten 
Published: June 2018

Skeptics, by being skeptical about the certainty, accuracy and truth claims, defend that there are no objective accuracy or certainty; and for this reason, it is not possible to have an epistemological justification. The arguments on skepticism claiming that knowledge is not possible or proofs are inadequate in justifying knowledge have caused that skepticism has been considered as a notorious concept and sometimes it has been considered as a destructive activity. There is the idea that knowledge and certainty are possible behind these considerations. On this basis, skepticism has been conceived as the rejection of knowledge, beliefs and proofs, and therefore, the arguments of skepticism have been presented as an epistemic predicament. In this study, the arguments of whether skepticism has faced an epistemological predicament or not will be dealt with. For this purpose, the etymological investigation of skepticism will be performed, and then it will be claimed that there are two types of skepticisms, which are the excessive one and the moderate one. After skeptical arguments are defined, it will be claimed that excessive skepticism is in an epistemological predicament; however, moderate skepticism has been saved from this predicament by holding tightly to some arguments. In this way, the negative criticisms towards skepticism will have an unfair position in the face of moderate skepticism. In other words, it will appear that that the charge of skepticism with denialism is faulty and incomplete. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetSkeptikler kesinlik, doğruluk ve hakikat iddialarından şüphe duyarak nesnel bir doğruluğun ya da kesinliğin olmadığını; dolayısıyla epistemolojik olarak gerekçelendirmenin de mümkün olmadığını savunmaktadır. Bilginin mümkün olmadığı ya da bilgiyi gerekçelendirmede kanıtların yetersiz olduğu şeklindeki skeptik tezler, skeptisizmin kötü bir unvanla anılmasına hatta yıkıcı bir uğraş gibi değerlendirilmesine neden olmaktadır. Bu değerlendirmelerin arkasında bilginin ve kesinliğin mümkün olduğu fikri yer almaktadır. Bu fikre dayanarak skeptisizm bilginin, inançların ve kanıtların reddi gibi düşünülmekte ve buna bağlı olarak skeptisizmin tezleri epistemik bir çıkmaz gibi sunulmaktadır. Bu çalışmada skeptisizmin epistemolojik bir çıkmaza girip girmediği ele alınacaktır. Bunun için öncelikle skeptisizmin etimolojik araştırması yapılacak ve daha sonra aşırı ve ılımlı olmak üzere iki skeptisizm türü olduğu ileri sürülecektir. Skeptik argümanlar ortaya koyulduktan sonra aşırı skeptisizmin epistemolojik çıkmazda olduğu; ancak ılımlı skeptisizmin bazı varsayımlara tutunarak bu çıkmazdan kurtulabildiği iddia edilecektir. Böylece skeptisizme yönelik olumsuz eleştiriler ılımlı skeptisizmle haksız bir konuma girecektir. Başka bir deyişle skeptisizmi inkarcılıkla suçlamanın hatalı ve eksik olduğu ortaya çıkacaktır.
Kandungan Pigmen Polar Dan Biomassa Pada Mikroalga Dunaliella Salina Dengan Salinitas Berbeda
Authors: Djunaedi Ali , Suryono Chrisna Adi , Sardjito Sardjito 
Published: June 2018

Polar pigments content and biomass of Dunaliella salina are affected by salinity related to osmotic pressure and density of media. This study was to determine the effect of salinity on pigment contents and dried biomass of microalgae D. salina. The cultivation used microalgae derived from Balai Besar Pengembangan Budidaya Air Payau (BBPBAP), Jepara. Research method was the Laboratory study with a Completely Randomized Design (CRD). Consisting of one treatment with five stages of salinity treatments: 20 ppt, 25 ppt, 30 ppt, 35 ppt, and 40 ppt and using three times of repetition. Analysis of pigments used UV-Vis spectrophotometric extracted with acetone as the solvent. Harvesting time was when it reached at the stationair phase using flocculation method. The results showed that salinity had the significant effect (P <0.05) on polar pigment and dry biomass. The treatments of 35 ppt showed that the highest content phycocyanin and allophycocyanin pigments were 11.341 mg/gram and 9.644 mg/gram respectively. The highest dry biomass was achieved at 35 ppt salinity treatment at 0.789 gram/L. Keywords: Dunaliella salina, salinity, Polar pigment, Biomass. Kandungan pigmen polar dan biomassa Dunaliella salina dipengaruhi oleh salinitas yang berkaitan dengan tekanan osmotik dan densitas media. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh salinitas terhadap kandungan pigmen polar dan biomassa kering D. salina. Biota uji diperoleh dari Balai Besar Pengembangan Budidaya Air Payau (BBPBAP), Jepara. Metode penelitian adalah eksperimen laboratoris dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 1 perlakuan dengan 5 taraf perlakuan salinitas, yaitu: 20 ppt, 25 ppt, 30 ppt, 35 ppt, dan 40 ppt dengan pengulangan sebanyak 3 kali. Analisis pigmen dengan metode spektrofotometer UV-Vis yang diekstraksi menggunakan larutan aseton. Pemanenan biomassa pada fase stasioner dengan menggunakan metode flokulasi. Hasil penelitian menunjukkan bahwa salinitas berpengaruh terhadap kandungan pigmen dan biomassa kering Dunaliella salina. Perlakuan salinitas 35 ppt menghasilkan kadar pigmen fikosianin dan allofikosianin tertinggi, yaitu 11,341 mg/gram, dan 9,644 mg/gram, serta menghasilkan biomassa kering tertinggi, yaitu 0,789 gram/L. Kata Kunci : Dunaliella salina, Salinitas, Pigmen polar, Biomassa
Crystal structure of ethyl 4-(3,4-dimethylphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C23H29NO3
Authors: Chen Xuanhuang , Wu Feng , Huang Manwei , Zheng Jinqing , Yu Zhengxi , Chen Jinhui 
Published: June 2018

Abstract
C23H29NO3, orthorhombic, Pbcn (no. 60), a = 18.781(7) Å, b = 15.749(6) Å, c = 14.081(5) Å, V = 4165(3) Å3, Z = 8, R
gt(F) = 0.0614, wR
ref(F
2) = 0.1874, T = 296(2) K.
Test and Evaluation for Effects of Freeze-Thaw Cycles on Fracture Performance of Epoxy Asphalt Concrete Composite Structure
Authors: Zhang Meng , Qian Zhendong , Huang Qibo 
Published: June 2018

Abstract
The fracture performance of epoxy asphalt concrete (EAC) pavement on the top of orthotropic steel deck bridges is influenced by repeating freeze-thaw (FT) cycles in seasonally frozen areas. In this article, the effects of FT cycles on the fracture behavior of EAC composite structures are investigated considering the climatic conditions of Beijing in China. EAC beams were exposed to different FT cycles for conditioning, then the flexural modulus was determined by three-point bending tests. Additionally, the plane-strain fracture toughness and the mechanical response of the EAC composite beams were investigated through numerical simulation. The results show that the flexural modulus of EAC decreases with FT conditioning. Specifically, the flexural modulus decreases by 60.3 % after 30 FT cycles. Nevertheless, the plane-strain fracture toughness and the maximum transverse tensile stress of the EAC composite beams decrease in the first 15 FT cycles and increases for the rest of the FT cycles, while the maximum transverse tensile strain decreases in the first 10 FT cycles and increases for the rest of the FT cycles. The maximum interlayer shear stress between EAC layers is smaller than that between the lower EAC layer and the steel deck. No significant damage is observed in the bonding layer exposed to FT conditioning.
Study on Damage Mechanism of Ultrasonic Radiation Rod in Aluminum Alloy Casting
Authors: Su Sichao , Li Xiaoqian 
Published: June 2018

Abstract
Ultrasound has been applied to aluminum alloy casting to improve the properties of the alloy. However, the damage caused by the ultrasonic radiation rod seriously affects the continuous and steady propagation of ultrasonic waves in the molten aluminum. In this work, a 34-mm long and 20-mm thick titanium alloy plate was cut from the intermediate position of a radiation rod that had been severely eroded. Thereafter, 24 specimens were cut from the titanium alloy plate, and their damage interface was observed by scanning electron microscopy. The results show that the damage of the radiation rod is mainly caused by the ultrasonic cavitation effect and chemical reaction, which provides theoretical guidance for the protection of the radiation rod.
Significance Testing for Allelic Heterogeneity
Authors: Deng Yangqing , Pan Wei 
Published: June 2018

Abstract
It is useful to detect allelic heterogeneity (AH), i.e., the presence of multiple causal SNPs in a locus, which, for example, may guide the development of new methods for fine mapping and determine how to interpret an appearing epistasis. In contrast to Mendelian traits, the existence and extent of AH for complex traits had been largely unknown until Hormozdiari et al. proposed a Bayesian method, called causal variants identification in associated regions (CAVIAR), and uncovered widespread AH in complex traits. However, there are several limitations with CAVIAR. First, it assumes a maximum number of causal SNPs in a locus, typically up to six, to save computing time; this assumption, as will be shown, may influence the outcome. Second, its computational time can be too demanding to be feasible since it examines all possible combinations of causal SNPs (under the assumed upper bound). Finally, it outputs a posterior probability of AH, which may be difficult to calibrate with a commonly used nominal significance level. Here, we introduce an intersection-union test (IUT) based on a joint/conditional regression model with all the SNPs in a locus to infer AH. We also propose two sequential IUT-based testing procedures to estimate the number of causal SNPs. Our proposed methods are applicable to not only individual-level genotypic and phenotypic data, but also genome-wide association study (GWAS) summary statistics. We provide numerical examples based on both simulated and real data, including large-scale schizophrenia (SCZ) and high-density lipoprotein (HDL) GWAS summary data sets, to demonstrate the effectiveness of the new methods. In particular, for both the SCZ and HDL data, our proposed IUT not only was faster, but also detected more AH loci than CAVIAR. Our proposed methods are expected to be useful in further uncovering the extent of AH in complex traits.
CURRICULUM ANALYSIS TEACHER PROFESSIONAL EDUCATION PROGRAM (PPG) OF ISLAMIC EDUCATION IN INDONESIA
Authors: Fauzan Fauzan , Bahrissalim Bahrissalim 
Published: June 2018

Abstract The existence of Professional Teacher Education program (PPG) becomes a demand after the Law of Teachers and Lecturers (UU G-D) requires professional teachers to have an educator certificates. Professional education contains practical activities of applying academic educational ability in professional activities of teachers in schools along with systematic supervision mechanisms and in a relatively adequate time (at least one year or two semesters). The substance of the Teacher Professional program curriculum rests on the accommodation of teachers' competence, pedagogic, professional, personal, and social. The demands of the teacher's competence spawned several offers of learning expenses that became a person's reinforcement to become a professional teacher, whether related to the content of teaching materials or the strengthening of teaching skills. The structure of the PPG program curriculum contains workshops on learning tool development, teaching exercises through micro teaching- learning, peer learning, and field experience programs (PPL), and pedagogy enrichment programs. Abstrak Keberadaan Program Profesi Guru (PPG) menjadi tuntutan setelah UU G-D mempersyaratkan guru profesional memiliki sertifikat pendidik. Pendidikan profesi berisi kegiatan praktik menerapkan kemampuan akademik kependidikan dalam kegiatan profesional guru di sekolah disertai mekanisme pembimbingan dan supervisi yang sistematis dan dalam waktu yang relatif memadai (sekurang-kurangnya satu tahun atau dua semester). Substansi kurikulum Program Profesi Guru (PPG) bersandar pada akomodasi tuntutan kompetensi guru, yakni pedagogik, professional, personal, dan sosial. Tuntutan kompetensi guru tersebut melahirkan beberapa tawaran beban belajar yang menjadi penguat seseorang menjadi guru professional, apakah terkait dengan konten materi ajar atau penguatan teaching skill. Struktur kurikulum program PPG berisi lokakarya pengembangan perangkat pembelajaran, latihan mengajar melalui pembelajaran mikro, pembelajaran pada teman sejawat, dan program pengalaman lapangan (PPL), dan program pengayaan bidang studi dan/atau pedagogi. How to Cite : Fauzan., Bahrissalim. (2017). Curriculum Analysis Teacher Professional Education Program (PPG) of Islamic Education in Indonesia. TARBIYA: Journal of Education in Muslim Society, 4(2), 148-161. doi:10.15408/tjems.v4i2.6400. Permalink/DOI: http://dx.doi.org/10.15408/tjems.v4i2.6400
META-ANALYSIS OF THE EFFECT OF LEARNING INTERVENTION TOWARD MATHEMATICAL THINKING ON RESEARCH AND PUBLICATION OF STUDENT
Authors: Kadir Kadir 
Published: June 2018

Abstract The purpose of this study was to analyse the effect of mathematics learning intervention on students' mathematical thinking ability. The research method used survey of thesis of the student. The effect of studies applying learning to mathematical thinking was done using meta-analysis techniques. The research finding that research conducted by students by providing learning intervention was able to improve students' mathematical thinking ability. Aspects of mathematical thinking ability include connection ability, communication, representation, problem-solving, logical, critical, creative, analytical, generalization, quantitative, and adaptive thinking. The types of research used by students are dominated by the experiment with mix-method approach and classroom action research. Other methods, research development. The research and publication at the Department of Mathematics Education, Faculty of Educational Sciences have adapted to the trend of mathematics education research on the national and international level. Abstrak Tujuan penelitian ini adalah menganalisis efektivitas pengaruh intervensi pembelajaran matematika terhadap kemampuan berpikir matematis siswa. Metode penelitian yang digunakan adalah survei terhadap skripsi dan publikasi mahasiswa. Pengaruh penelitian-penelitian yang menerapkan pembelajaran terhadap kemampuan berpikir matematis dianalisis dengan teknik meta-analisis. Temuan penelitian mengungkapkan bahwa secara keseluruhan penelitian-penelitian yang dilakukan mahasiswa dengan memberikan intervensi pembelajaran ternyata mampu meningkatkan kemampuan berpikir matematis siswa. Aspek kemampuan berpikir matematika yang meliputi: kemampuan koneksi, komunikasi, representasi, pemecahan masalah, kemampuan berpikir: logis, kritis, kreatif, reflektif, intuitif, penalaran: analalogi, generalisasi, kuantitatif, kreatif, dan adaptif. Metode penelitian yang digunakan mahasiswa didominasi metode eksperimen dengan pendekatan mix-method dan penelitian tindakan kelas. Disamping itu terdapat beberapa mahasiswa memilih metode penelitian pengembangan. Hasil penelitian dan publikasi pada Program Studi Pendidikan Matematika telah menyesuaikan dengan tren penelitian pendidikan pendidikan matematika baik pada level nasional maupun internasional. How to Cite : Kadir. (2017). Meta-Analysis of the Effect of Learning Intervention Toward Mathematical Thinking on Research and Publication of Student. TARBIYA: Journal of Education in Muslim Society, 4(2), 162-175. doi:10.15408/tjems.v4i2.8010. Permalink/DOI: http://dx.doi.org/10.15408/tjems.v4i2.8010