bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphenols: Novel Signaling Pathways
Authors: Ricketts Marie-Louise , Ferguson Bradley S. 
Published: April 2018

Background:
Cardiovascular disease (CVD) is currently the leading cause of death globally. The
metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density
lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a
significant risk factor for the development of CVD. Non-alcoholic fatty liver disease (NAFLD), often referred to
as the hepatic manifestation of MetS, is a constellation of progressive liver disorders closely linked to obesity,
diabetes, and insulin resistance. NAFLD initially presents as relatively benign, non-progressive hepatic steatosis,
but it may, in certain individuals, progress to nonalcoholic steatohepatitis, fibrosis, cirrhosis, or hepatocellular
carcinoma. Currently, there are no validated treatments for NAFLD. Polyphenols are important bioactive dietary
compounds and may represent a natural complementary and integrative therapy for the treatment of CVDassociated
risk factors, including elevated serum cholesterol and triglyceride levels, as well as NAFLD. Understanding
their molecular mechanisms of action is important in the design of future human intervention studies.

Methods:
Several studies utilizing in vitro and in vivo models have helped to identify underlying molecular
mechanisms of action of polyphenols.

Results:
This review will highlight recent advances regarding the molecular actions of dietary procyanidins, with
a special focus on those originating from procyanidin-rich grape seed extracts, with a focus on the signaling
pathways utilized to exert beneficial metabolic effects.

Conclusion:
Modulation of nuclear receptor activity and histone deacetylase inhibition has been identified as
underlying mechanisms contributing to procyanidin-mediated amelioration of dyslipidemia and steatosis.
Paranormal Health Beliefs: Relations Between Social Dominance Orientation and Mental Illness
Authors: Anna Rosa Donizzetti 
Published: April 2018

Background:Illusory beliefs are false beliefs that fulfill the function of creating a “filter” through which reality acquires order and meaning. Even though many studies have been conducted on this topic, there have been few investigations into the role illusory beliefs play, as specifically related to health concerns.Objective:The current research takes up the objective of investigating the relationships between paranormal health beliefs (with specific reference to pseudo-scientific beliefs of a bio-medical nature), social dominance orientation, god-centered health locus of control, and coping by turning to religion, as well as their predictive role with respect to mental illness.Methods:432 adults (76.8% women) were contacted, with a median age of 24.9 years (DS=11.6). A self-report questionnaire, composed of various instruments, was administered to the participants. The questionnaire consisted of the following instruments:Paranormal Health Beliefs Scale, Social Dominance Orientation, Health Locus of Control Scale, Coping Orientation to Problems Experienced and General Health Questionnaire.Descriptive and correlational analyses were performed, along with structural equations modeling.Results:Based on the analyses conducted, it emerged that social dominance orientation and the god-centered health locus of control are antecedents for pseudo-scientific beliefs of a bio-medical nature, which, in turn, affect coping by turning to religion. Coping by turning to religion predicts perceived illness.Conclusions:These results provide a useful direction for understanding the factors that influence the health decisions of individuals and, therefore, must be taken into consideration even in the most diverse health contexts.
Phase Transitions in Nanocomposites Obtained by Introducing KNO3 into the Pores of Nanosized Al2O3 Films
Authors: Milinskiy Alexey Y. , Baryshnikov Sergey V. 
Published: April 2018

Introduction:
Comparative studies of phase transitions in nanocomposites on the base of
KNO3 and Al2O3 films with pores of 240 and 45 nm were carried out.

Experiment:
The temperature dependences of the linear dielectric constant and the amplitude of the
third harmonic were measured. The measurements were carried out in the heating and cooling regime
in the range from room temperature to 463 K. Anomalies, corresponding to structural phase
transitions, were observed.

Results & Conclusion:
A considerable expansion of the temperature range of the potassium nitrate
ferroelectric phase III was observed upon cooling, which increased with decreasing pore size of the
Al2O3 films. The structural transition upon heating from phase II to phase I for nanocomposites
with a pore size of 45 nm shifted relative to the transition in bulk KNO3 by 2 K toward high temperatures,
whereas the temperature change for the sample in the Al2O3 film with pores of 240 nm
did not occur.
Source Analysis of Nitrate Nitrogen in Groundwater Based on Different Modes of Land use
Authors: Liu Ze-Jun , Wu Yan , Liang Qiyang , Xia Jiangtao , Li Jian , Huang Yong 
Published: April 2018

Background:
The study area is located in the Hebei province Luanxian section along the
Luanhe River. The right of Luanhe River is arranged with 3 monitoring sections and is laid with 5
wells in the A-A section and B-B section and 1 well on the floodplain (inside the dike), the distance
from the river level is about 10m. The distance between the 4 wells outside the dike is 20m, 50m,
200m and 1500m respectively. 2 wells are arranged on the C-C section, so there are 13 observation
wells in the study area. 3# wells and 11# wells have used existing monitoring wells, so 11 wells have
been set up actually. The monitoring wells are designed to monitor groundwater level, groundwater
quality and isotope analysis.

Methods:
In the upstream of Luanhe’s A-A section of the No. 4 well near the edge of the woods and
downstream of the B-B section of the No. 8 well near the edge of farmland (wheat), each point of soil
is sampled to determine the content of nitrate nitrogen and 15N isotope ratio in soil profile. The depth
of soil is sampled from surface to groundwater level, the total depth is about 2.5m. Taking about 1kg
soil samples at 20cm every time from the ground surface and collect and seal in plastic bags and number.
The sampling time was November 2015, March 2016, May 2016 and July 2016, taking 4 times.

Results:
The analysis showed that higher nitrate content in soil is within 0-60cm, and is same as the
depth of fertilizing the crops (including animal manure), so when estimating the proportion of
groundwater in nitrate, nitrate content in 0-60cm is assumed as the initial value; which is close to the
underground water level in the soil and is regarded as the final value of 60cm, that is, the final value of
nitrate into the groundwater, which can estimate the soil nitrate into groundwater ratio.

Conclusion:
The sources of nitrate in groundwater are complex and related to many factors, such as
river water, soil and so on. According to the content of nitrogen and oxygen isotopes, it determines the
main source of nitrate nitrogen:soil and Luanhe River. The results showed that the ratio of nitrate to
groundwater in the forest soil was 20%~80.8%, and the average value was 56.3%. The proportion of
nitrate in the soil in the wheat field was 6.8%~98.2%, with an average value of 48.3%. Nitrate nitrogen
from water in proportion of large changes with the seasons, the upper reaches of the Luanhe River
(near No. 2 wells) for 0~19.6%; the Luanhe River (near No. 7 wells) for 0~31.5%.
Electronic Health Program to Empower Patients in Returning to Normal Activities After Colorectal Surgical Procedures: Mixed-Methods Process Evaluation Alongside a Randomized Controlled Trial (Preprint)
Authors: den Bakker Chantal M , Huirne Judith AF , Schaafsma Frederieke G , de Geus Charlotte , Bonjer Hendrik J , Anema Johannes R 
Published: April 2018

BACKGROUND

Long-term recovery takes longer than expected despite improved surgical techniques and Enhanced Recovery After Surgery programs. An electronic health (eHealth) care program (“ikherstel”) was developed to partially substitute perioperative care for patients undergoing colorectal surgical procedures. Successfully tested eHealth programs are not always implemented in usual care, and it is, therefore, important to evaluate the process to optimize future implementation.

OBJECTIVE

The aim of this study was to evaluate whether the eHealth intervention was executed as planned.

METHODS

A mixed-methods process evaluation was carried out alongside a multicenter randomized controlled trial (RCT). This evaluation was performed using the Linnan and Steckler framework for the quantitative part of this study, measuring the components reach, dose delivered, dose received, fidelity, and participants’ attitudes. Total implementation scores were calculated using the averaging approach, in which the sum of all data points is divided by the number of data points and the total adherence to the protocol is measured. For the qualitative part, the Unified Theory of Acceptance and Use of Technology framework was used. The quantitative data were based on participants’ questionnaires, a logistic database, a weblog, and participants’ medical files and were obtained by performing semistructured interviews with participants of the RCT.

RESULTS

A total of 151 participants of 340 eligible patients were included in the RCT, of which 73 participants were allocated to the intervention group. On the basis of the quantitative process data, total implementation scores for the website, mobile app, electronic consult, and activity tracker were 64%, 63%, 44%, and 67%, respectively. Participants in the qualitative part experienced the program as supportive and provided guidance on their recovery process after colorectal surgery. Most frequently mentioned barriers were the limited interaction with and feedback from health care professionals and the lack of tailoring of the convalescence plan in case of a different course of recovery.

CONCLUSIONS

The intervention needs more interaction with and feedback from health care professionals and needs more tailored guidance in case of different recovery or treatment courses. To ensure a successful implementation of the program in daily practice, some adjustments are required to optimize the program in a blended care form.

CLINICALTRIAL

Netherlands Trial Registry NTR5686; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC= 5686 (Archieved by WebCite at http://www.webcitation.org/75LrJaHrr)
Secular Trends in Infection-Related Mortality after Kidney Transplantation
Authors: Kinnunen Susanna , Karhapää Pauli , Juutilainen Auni , Finne Patrik , Helanterä Ilkka 
Published: April 2018

Background and objectives
Infections are the most common noncardiovascular causes of death after kidney transplantation. We analyzed the current infection-related mortality among kidney transplant recipients in a nationwide cohort in Finland.

Design, setting, participants, & measurements
Altogether, 3249 adult recipients of a first kidney transplant from 1990 to 2012 were included. Infectious causes of death were analyzed, and the mortality rates for infections were compared between two eras (1990–1999 and 2000–2012). Risk factors for infectious deaths were analyzed with Cox regression and competing risk analyses.

Results
Altogether, 953 patients (29%) died during the follow-up, with 204 infection-related deaths. Mortality rate (per 1000 patient-years) due to infections was lower in the more recent cohort (4.6; 95% confidence interval, 3.5 to 6.1) compared with the older cohort (9.1; 95% confidence interval, 7.6 to 10.7); the incidence rate ratio of infectious mortality was 0.51 (95% confidence interval, 0.30 to 0.68). The main causes of infectious deaths were common bacterial infections: septicemia in 38% and pulmonary infections in 45%. Viral and fungal infections caused only 2% and 3% of infectious deaths, respectively (such as individual patients with Cytomegalovirus pneumonia, Herpes simplex virus meningoencephalitis, Varicella zoster virus encephalitis, and Pneumocystis jirovecii infection). Similarly, opportunistic bacterial infections rarely caused death; only one death was caused by Listeria monocytogenes, and two were caused by Mycobacterium tuberculosis. Only 23 (11%) of infection-related deaths occurred during the first post-transplant year. Older recipient age, higher plasma creatinine concentration at the end of the first post-transplant year, diabetes as a cause of ESKD, longer pretransplant dialysis duration, acute rejection, low albumin level, and earlier era of transplantation were associated with increased risk of infectious death in multivariable analysis.

Conclusions
The risk of death due to infectious causes after kidney transplantation in Finland dropped by one half since the 1990s. Common bacterial infections remained the most frequent cause of infection-related mortality, whereas opportunistic viral, fungal, or unconventional bacterial infections rarely caused deaths after kidney transplantation.
PENGARUH PEMBERIAN MONOSODIUM GLUTAMAT TERHADAP KADAR HORMON ESTRADIOL DAN KADAR HORMON PROGESTERON PADA TIKUS PUTIH BETINA (Rattus norvegicus)
Authors: Ani Andri 
Published: April 2018

<p>Perubahan pola demografi di negara maju dan negara berkembang, angka kejadian infertilitas di negara maju dilaporkan sekitar 5%-8% dan di negara berkembang sekitar 30%.WHO memperkirakan sekitar 8%-10% atau sekitar 50-80 juta pasangan suami istri di seluruh dunia mengalami masalah infertilitas, sehingga membuat infertilitas menjadi masalah mendesak. Untuk itu diperlukan pengendalian infertilitas, salah satunya adalah kewaspadaan perubahan gaya hidup, perubahan ini juga mempengaruhi pola konsumsi makanan dengan lebih banyak mengkonsumsi jenis makanan cepat saji yang banyak mengandung zat aditif (penyedap rasa. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian monosodium glutamate terhadap kadar hormon estradiol dan kadar hormon progesteron pada tikus putih betina ( <em>Rattus norvegicus ).</em></p><p>Penelitian ini menggunakan metode pendekatan <em>post test only control group design,</em> terhadap tikus putih betina dengan berat 200 – 250 gr. Sampel terdiri dari 24 ekor tikus yang dibagi 4 kelompok yaitu kelompok kontrol ( K ), perlakuan I, II dan III . Kelompok perlakuan diberikan monosodium glutamat dengan dosis masing-masing : 45 mg, 54 mg dan 63 mg setiap hari diberikan peroral yang dilarutkan dengan aquabides 2 ml selama 20 hari yang dimulai pada awal fase proestrus. Setelah 20 hari perlakuan tikus di korbankan dan diambil darahnya. Pemeriksaan kadar hormone estradiol dan progesteron menggunakan Elisa Spectrophotometer. Kemudian hasilnya dianalisa dengan menggunakan One Way <em>ANOVA</em> dan dilanjutkan dengan uji <em>Multiple Comparison</em> jenis<em> Bonferroni.</em></p><p>Hasil penelitian pemberian monosodium glutamat dengan dosis 45 mg/ ekor/ hari, 54 mg/ekor/ hari dan 63 mg/ ekor /hari dapat menurunkan kadar hormon estradiol tikus putih betina <em>(Rattus norvegicus)</em> secara signifikan. Dan pemberian monosodium glutamate dengan dosis 45 mg/ ekor/ hari dapat menurunkan kadar hormon progesteron tikus putih betina<em> (Rattus norvegicus)</em> walaupun tidak berpengaruh secara signifikan , dan pada dosis 54 mg/ekor/ hari dan 63 mg/ ekor /hari memberikan pengaruh terhadap penurunan kadar hormon progesteron secara signifikan.</p><p>Dapat di simpulkan ada pengaruh pemberian monosodium glutamat terhadap penurunan kadar hormon estradiol dan kadar hormon progesteron <em> </em>pada tikus putih betina (<em>Rattus norvegicus).</em> Disarankan Untuk pemeriksaan kadar hormon sebaiknya dilakukan segera setelah pengambilan darah. </p>
Measurement of Air Springs Volume Using Indirect Method in the Design of Selected Pneumatic Devices
Authors: Urbanský Matej , Homišin Jaroslav , Kaššay Peter , Krajňák Jozef 
Published: April 2018

Abstract
At our department, we deal with continuous tuning of torsional oscillating mechanical systems (TOMS) during their operation in terms of torsional oscillation size. Therefore, a new mobile mechanical system was built for purposes of research and presentation of the TOMS continuous tuning using extremal control method, which main advantage is that we do not need to know a mathematical model of the mechanical system. The new mobile device is equipped with a special compressed air distribution system, which important components are air springs. The air springs are modified and used as air pressure tanks with various functions in the mobile device. Therefore, it is important to know the magnitude of the air springs inner volume. This paper deals with determination of air springs volume using indirect method, which is based on the air pressure measurement and also the comparison of obtained results with the results computed from air springs manufacturer data.
Numerical Analysis of Stress Intensity Factor in Specimens with Different Fillet Geometry Subjected to Bending
Authors: Lewandowski Janusz , Rozumek Dariusz 
Published: April 2018

Abstract
The article presents the maps of xx stress component and compares values of analytical and numerical calculations for the stress intensity factor range of welded specimens with fillet welds which subjected to cyclic bending. The tests were performed under constant value of moment amplitude Ma = 9.20 N·m and stress ratio R = σmin/ σmax = −1. The specimens were made of drag steel rod S355. The specimens were solid and welded. The numerical models were simulated with ABAQUS suite and numerical calculations performed with FRANC3D software.
Image Processing Techniques for ROI Identification in Rheumatoid Arthritis Patients from Thermal Images
Authors: Wasilewska Agnieszka , Pauk Jolanta , Ihnatouski Mikhail 
Published: April 2018

Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease that manifests itself by joint inflammation, swelling, pain, tenderness and may involve extra-articular organs in severe cases. Joint inflammatory lesions are associated with higher temperature due to increased vascularity in the area of inflamed tissues. This papers aimed to identify heat patterns from ROIs to interpret the presence of inflammation in rheumatoid arthritis patients. The thermovisual image sequences were collected from 65 patients with Rheumatoid Arthritis (RA). Infrared images were generated by a thermal scanning camera (FLIR E60bx Systems Inc., USA). Separate recordings of left and right foot temperature changes were performed for 3 minute periods. The temperature measurement was performed at the moment right after cold water immersion (post-cooling temperature) and at the moment after thermal recovery (post-recovery temperature). The recording of 3-minute foot thermal recovery was used for analysis. Automatically identified ROI corresponds to the area of the soft tissues covering cuboid and navicular bone.
Energy Absorbing Effectiveness – Different Approaches
Authors: Kotełko Maria , Ferdynus Mirosław , Jankowski Jacek 
Published: April 2018

Abstract
In the paper the study of different crashworthiness indicators used to evaluate energy absorbing effectiveness of thin-walled energy absorbers is presented. Several different indicators are used to assess an effectiveness of two types of absorbing structures, namely thin-walled prismatic column with flaws and thin-walled prismatic frustum (hollow or foam filled) in both cases subjected to axial compressive impact load. The indicators are calculated for different materials and different geometrical parameters. The problem of selection of the most appropriate and general indicators is discussed.
Water Retention in a Small Agricultural Catchment and its Potential Improvement by Design of Water Reservoirs – A Case Study of the Bílý Potok Catchment (Czechia)
Authors: Doležal Petr , Konečná Jana , Karásek Petr , Podhrázská Jana , Pochop Michal 
Published: April 2018

Abstract
Water retention in the landscape is discussed in the context of conservation and improvement of both its productive and non-productive functions. We analysed the retention potential of a small agricultural catchment associated with the Bílý potok brook, investigating the possibility to improve its retention capacity and slow down the surface runoff, thus increasing the underground water resources. Method of curve numbers was used for that purposes. From results, it emerged that present maximum water retention in the Bílý potok catchment is 96.2 mm. It could increase by 101.3 mm in case of grassing about 20% arable land threatened by soil erosion. As next possibility to retain water from precipitations in landscape, capacity and transformation effect of reservoirs designed in master plans was analysed. The latest programming tools working in the GIS environment were used to assess the retention capacity of both the catchment surface and the reservoirs. Analysing master plans in the catchment, it was found that 16 designed water reservoirs (from 31) have a good potential to intercept water and transform flood discharges. In the result, priority for building of reservoirs was recommended according to their pertinence and efficiency in the studied catchment. Presented complex approach can be widely implemented, especially for better effectivity and cohesion of landscape planning and land consolidations processes.
How Can Sweden Deal with Forest Management and Municipal Planning in the System of Ongoing Land-Use and Multilevel Planning?
Authors: Stjernström Olof , Pettersson Örjan , Karlsson Svante 
Published: April 2018

Abstract
This article studies the relation between territorial and functional planning by investigating the Swedish local comprehensive planning system and the forest management. The former is locally based and the latter is functionally based or sector-orientated. By interviewing planners from the County Administrative Boards responsible for monitoring the national interests in the Swedish municipalities and forest managers from the Regional Forest Agency Administration, we found out that forest- and municipality related issues that coincide or interact with each other is normally considered in the collaborative planning process based on consultations and cooperation between the involved stakeholders. Weaknesses in the collaborative planning system consists of lack of coordination between the involved legal frameworks as well as lack of local planning resources and in some cases competences.
Examining the Renewable Energy Investments in Hungarian Rural Settlements: The Gained Local Benefits and the Aspects of Local Community Involvement
Authors: Honvári Patrícia , Kukorelli Irén Szörényiné 
Published: April 2018

Abstract
The results of the paper are based on a research project which examines the renewable energy investments carried out in Hungarian rural settlements. The study will focus on the municipality-led renewable energy developments, determining the most important local benefits and the aspects of the local community involvement. Altogether 748 rural settlements have been identified, which have implemented at least one renewable energy project through the Environmental and Energy Operative Program between 2007 and 2013. A questionnaire has been sent out to these municipalities, and 159 full answers have been collected and analysed. We have investigated the importance and presence of local benefits deriving from renewable energy investments, and examined what effort is put into the information and involvement of the local community. The study concludes that although several local benefits occur at local level while implementing renewable energy projects, the effect of direct benefits remain at a low level. Furthermore, it can also be stated, that only moderate effort is put into the issue of local community involvement. The study also determines several major threats that can endanger the successfulness of the previous investments, and prevent the further renewable energy developments at local level.